data_9IV8
# 
_entry.id   9IV8 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9IV8         pdb_00009iv8 10.2210/pdb9iv8/pdb 
WWPDB D_1300049682 ?            ?                   
EMDB  EMD-60921    ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1  'Structure model' 1 0 2025-03-19 ? 
2  'EM metadata'     1 0 2025-03-19 ? 
3  'Additional map'  1 0 2025-03-19 1 
4  'Additional map'  1 0 2025-03-19 2 
5  FSC               1 0 2025-03-19 ? 
6  'Half map'        1 0 2025-03-19 1 
7  'Half map'        1 0 2025-03-19 2 
8  Image             1 0 2025-03-19 ? 
9  'Primary map'     1 0 2025-03-19 ? 
10 'Structure model' 1 1 2025-06-04 ? 
# 
loop_
_pdbx_audit_revision_details.ordinal 
_pdbx_audit_revision_details.revision_ordinal 
_pdbx_audit_revision_details.data_content_type 
_pdbx_audit_revision_details.provider 
_pdbx_audit_revision_details.type 
_pdbx_audit_revision_details.description 
_pdbx_audit_revision_details.details 
1 1 'Structure model' repository 'Initial release' ? ? 
2 2 'EM metadata'     repository 'Initial release' ? ? 
3 3 'Additional map'  repository 'Initial release' ? ? 
4 4 'Additional map'  repository 'Initial release' ? ? 
5 5 FSC               repository 'Initial release' ? ? 
6 6 'Half map'        repository 'Initial release' ? ? 
7 7 'Half map'        repository 'Initial release' ? ? 
8 8 Image             repository 'Initial release' ? ? 
9 9 'Primary map'     repository 'Initial release' ? ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 10 'Structure model' 'Data collection'     
2 10 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 10 'Structure model' citation        
2 10 'Structure model' citation_author 
3 10 'Structure model' em_admin        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  10 'Structure model' '_citation.country'                 
2  10 'Structure model' '_citation.journal_abbrev'          
3  10 'Structure model' '_citation.journal_id_CSD'          
4  10 'Structure model' '_citation.journal_id_ISSN'         
5  10 'Structure model' '_citation.journal_volume'          
6  10 'Structure model' '_citation.pdbx_database_id_DOI'    
7  10 'Structure model' '_citation.pdbx_database_id_PubMed' 
8  10 'Structure model' '_citation.title'                   
9  10 'Structure model' '_citation.year'                    
10 10 'Structure model' '_em_admin.last_update'             
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9IV8 
_pdbx_database_status.recvd_initial_deposition_date   2024-07-23 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Cryo-EM structure of human NCX1 in PIP2 diC8 bound state' 
_pdbx_database_related.db_id          EMD-60921 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              youxing.jiang@utsouthwestern.edu 
_pdbx_contact_author.name_first         Youxing 
_pdbx_contact_author.name_last          Jiang 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-1874-0504 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Xue, J.'   1 ? 
'Jiang, Y.' 2 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Elife 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           2050-084X 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            14 
_citation.language                  ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.title                     
'Structural mechanisms of PIP 2 activation and SEA0400 inhibition in human cardiac sodium-calcium exchanger NCX1.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.7554/eLife.105396 
_citation.pdbx_database_id_PubMed   40433952 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Xue, J.'     1 0000-0002-7331-1382 
primary 'Zeng, W.'    2 ?                   
primary 'John, S.'    3 0000-0002-1232-9140 
primary 'Attiq, N.'   4 ?                   
primary 'Ottolia, M.' 5 0000-0002-5114-8887 
primary 'Jiang, Y.'   6 0000-0002-1874-0504 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Sodium/calcium exchanger 1' 109181.070 1 ? ? ? ? 
2 non-polymer syn 'CALCIUM ION' 40.078     5 ? ? ? ? 
3 non-polymer syn 
;[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
;
746.566    1 ? ? ? ? 
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        'Na(+)/Ca(2+)-exchange protein 1,Solute carrier family 8 member 1' 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATV
YFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHN
FTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFF
FFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLEVDERDQDDE
EARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGATENDPVSKIFFEQGTYQCLENCGTV
ALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEAS
EDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGG
EDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKYLFGQPVFRKVH
AREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWR
EQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHF
GCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPG
TLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGFAAAGGSWSHPQF
EKGGGSGGGSGGSAWSHPQFEK
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATV
YFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHN
FTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFF
FFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLEVDERDQDDE
EARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGATENDPVSKIFFEQGTYQCLENCGTV
ALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEAS
EDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGG
EDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKYLFGQPVFRKVH
AREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWR
EQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHF
GCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPG
TLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGFAAAGGSWSHPQF
EKGGGSGGGSGGSAWSHPQFEK
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'CALCIUM ION' CA  
3 
;[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
;
PIO 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   TYR n 
1 3   ASN n 
1 4   MET n 
1 5   ARG n 
1 6   ARG n 
1 7   LEU n 
1 8   SER n 
1 9   LEU n 
1 10  SER n 
1 11  PRO n 
1 12  THR n 
1 13  PHE n 
1 14  SER n 
1 15  MET n 
1 16  GLY n 
1 17  PHE n 
1 18  HIS n 
1 19  LEU n 
1 20  LEU n 
1 21  VAL n 
1 22  THR n 
1 23  VAL n 
1 24  SER n 
1 25  LEU n 
1 26  LEU n 
1 27  PHE n 
1 28  SER n 
1 29  HIS n 
1 30  VAL n 
1 31  ASP n 
1 32  HIS n 
1 33  VAL n 
1 34  ILE n 
1 35  ALA n 
1 36  GLU n 
1 37  THR n 
1 38  GLU n 
1 39  MET n 
1 40  GLU n 
1 41  GLY n 
1 42  GLU n 
1 43  GLY n 
1 44  ASN n 
1 45  GLU n 
1 46  THR n 
1 47  GLY n 
1 48  GLU n 
1 49  CYS n 
1 50  THR n 
1 51  GLY n 
1 52  SER n 
1 53  TYR n 
1 54  TYR n 
1 55  CYS n 
1 56  LYS n 
1 57  LYS n 
1 58  GLY n 
1 59  VAL n 
1 60  ILE n 
1 61  LEU n 
1 62  PRO n 
1 63  ILE n 
1 64  TRP n 
1 65  GLU n 
1 66  PRO n 
1 67  GLN n 
1 68  ASP n 
1 69  PRO n 
1 70  SER n 
1 71  PHE n 
1 72  GLY n 
1 73  ASP n 
1 74  LYS n 
1 75  ILE n 
1 76  ALA n 
1 77  ARG n 
1 78  ALA n 
1 79  THR n 
1 80  VAL n 
1 81  TYR n 
1 82  PHE n 
1 83  VAL n 
1 84  ALA n 
1 85  MET n 
1 86  VAL n 
1 87  TYR n 
1 88  MET n 
1 89  PHE n 
1 90  LEU n 
1 91  GLY n 
1 92  VAL n 
1 93  SER n 
1 94  ILE n 
1 95  ILE n 
1 96  ALA n 
1 97  ASP n 
1 98  ARG n 
1 99  PHE n 
1 100 MET n 
1 101 SER n 
1 102 SER n 
1 103 ILE n 
1 104 GLU n 
1 105 VAL n 
1 106 ILE n 
1 107 THR n 
1 108 SER n 
1 109 GLN n 
1 110 GLU n 
1 111 LYS n 
1 112 GLU n 
1 113 ILE n 
1 114 THR n 
1 115 ILE n 
1 116 LYS n 
1 117 LYS n 
1 118 PRO n 
1 119 ASN n 
1 120 GLY n 
1 121 GLU n 
1 122 THR n 
1 123 THR n 
1 124 LYS n 
1 125 THR n 
1 126 THR n 
1 127 VAL n 
1 128 ARG n 
1 129 ILE n 
1 130 TRP n 
1 131 ASN n 
1 132 GLU n 
1 133 THR n 
1 134 VAL n 
1 135 SER n 
1 136 ASN n 
1 137 LEU n 
1 138 THR n 
1 139 LEU n 
1 140 MET n 
1 141 ALA n 
1 142 LEU n 
1 143 GLY n 
1 144 SER n 
1 145 SER n 
1 146 ALA n 
1 147 PRO n 
1 148 GLU n 
1 149 ILE n 
1 150 LEU n 
1 151 LEU n 
1 152 SER n 
1 153 VAL n 
1 154 ILE n 
1 155 GLU n 
1 156 VAL n 
1 157 CYS n 
1 158 GLY n 
1 159 HIS n 
1 160 ASN n 
1 161 PHE n 
1 162 THR n 
1 163 ALA n 
1 164 GLY n 
1 165 ASP n 
1 166 LEU n 
1 167 GLY n 
1 168 PRO n 
1 169 SER n 
1 170 THR n 
1 171 ILE n 
1 172 VAL n 
1 173 GLY n 
1 174 SER n 
1 175 ALA n 
1 176 ALA n 
1 177 PHE n 
1 178 ASN n 
1 179 MET n 
1 180 PHE n 
1 181 ILE n 
1 182 ILE n 
1 183 ILE n 
1 184 ALA n 
1 185 LEU n 
1 186 CYS n 
1 187 VAL n 
1 188 TYR n 
1 189 VAL n 
1 190 VAL n 
1 191 PRO n 
1 192 ASP n 
1 193 GLY n 
1 194 GLU n 
1 195 THR n 
1 196 ARG n 
1 197 LYS n 
1 198 ILE n 
1 199 LYS n 
1 200 HIS n 
1 201 LEU n 
1 202 ARG n 
1 203 VAL n 
1 204 PHE n 
1 205 PHE n 
1 206 VAL n 
1 207 THR n 
1 208 ALA n 
1 209 ALA n 
1 210 TRP n 
1 211 SER n 
1 212 ILE n 
1 213 PHE n 
1 214 ALA n 
1 215 TYR n 
1 216 THR n 
1 217 TRP n 
1 218 LEU n 
1 219 TYR n 
1 220 ILE n 
1 221 ILE n 
1 222 LEU n 
1 223 SER n 
1 224 VAL n 
1 225 ILE n 
1 226 SER n 
1 227 PRO n 
1 228 GLY n 
1 229 VAL n 
1 230 VAL n 
1 231 GLU n 
1 232 VAL n 
1 233 TRP n 
1 234 GLU n 
1 235 GLY n 
1 236 LEU n 
1 237 LEU n 
1 238 THR n 
1 239 PHE n 
1 240 PHE n 
1 241 PHE n 
1 242 PHE n 
1 243 PRO n 
1 244 ILE n 
1 245 CYS n 
1 246 VAL n 
1 247 VAL n 
1 248 PHE n 
1 249 ALA n 
1 250 TRP n 
1 251 VAL n 
1 252 ALA n 
1 253 ASP n 
1 254 ARG n 
1 255 ARG n 
1 256 LEU n 
1 257 LEU n 
1 258 PHE n 
1 259 TYR n 
1 260 LYS n 
1 261 TYR n 
1 262 VAL n 
1 263 TYR n 
1 264 LYS n 
1 265 ARG n 
1 266 TYR n 
1 267 ARG n 
1 268 ALA n 
1 269 GLY n 
1 270 LYS n 
1 271 GLN n 
1 272 ARG n 
1 273 GLY n 
1 274 MET n 
1 275 ILE n 
1 276 ILE n 
1 277 GLU n 
1 278 HIS n 
1 279 GLU n 
1 280 GLY n 
1 281 ASP n 
1 282 ARG n 
1 283 PRO n 
1 284 SER n 
1 285 SER n 
1 286 LYS n 
1 287 THR n 
1 288 GLU n 
1 289 ILE n 
1 290 GLU n 
1 291 MET n 
1 292 ASP n 
1 293 GLY n 
1 294 LYS n 
1 295 VAL n 
1 296 VAL n 
1 297 ASN n 
1 298 SER n 
1 299 HIS n 
1 300 VAL n 
1 301 GLU n 
1 302 ASN n 
1 303 PHE n 
1 304 LEU n 
1 305 ASP n 
1 306 GLY n 
1 307 ALA n 
1 308 LEU n 
1 309 VAL n 
1 310 LEU n 
1 311 GLU n 
1 312 VAL n 
1 313 ASP n 
1 314 GLU n 
1 315 ARG n 
1 316 ASP n 
1 317 GLN n 
1 318 ASP n 
1 319 ASP n 
1 320 GLU n 
1 321 GLU n 
1 322 ALA n 
1 323 ARG n 
1 324 ARG n 
1 325 GLU n 
1 326 MET n 
1 327 ALA n 
1 328 ARG n 
1 329 ILE n 
1 330 LEU n 
1 331 LYS n 
1 332 GLU n 
1 333 LEU n 
1 334 LYS n 
1 335 GLN n 
1 336 LYS n 
1 337 HIS n 
1 338 PRO n 
1 339 ASP n 
1 340 LYS n 
1 341 GLU n 
1 342 ILE n 
1 343 GLU n 
1 344 GLN n 
1 345 LEU n 
1 346 ILE n 
1 347 GLU n 
1 348 LEU n 
1 349 ALA n 
1 350 ASN n 
1 351 TYR n 
1 352 GLN n 
1 353 VAL n 
1 354 LEU n 
1 355 SER n 
1 356 GLN n 
1 357 GLN n 
1 358 GLN n 
1 359 LYS n 
1 360 SER n 
1 361 ARG n 
1 362 ALA n 
1 363 PHE n 
1 364 TYR n 
1 365 ARG n 
1 366 ILE n 
1 367 GLN n 
1 368 ALA n 
1 369 THR n 
1 370 ARG n 
1 371 LEU n 
1 372 MET n 
1 373 THR n 
1 374 GLY n 
1 375 ALA n 
1 376 THR n 
1 377 GLU n 
1 378 ASN n 
1 379 ASP n 
1 380 PRO n 
1 381 VAL n 
1 382 SER n 
1 383 LYS n 
1 384 ILE n 
1 385 PHE n 
1 386 PHE n 
1 387 GLU n 
1 388 GLN n 
1 389 GLY n 
1 390 THR n 
1 391 TYR n 
1 392 GLN n 
1 393 CYS n 
1 394 LEU n 
1 395 GLU n 
1 396 ASN n 
1 397 CYS n 
1 398 GLY n 
1 399 THR n 
1 400 VAL n 
1 401 ALA n 
1 402 LEU n 
1 403 THR n 
1 404 ILE n 
1 405 ILE n 
1 406 ARG n 
1 407 ARG n 
1 408 GLY n 
1 409 GLY n 
1 410 ASP n 
1 411 LEU n 
1 412 THR n 
1 413 ASN n 
1 414 THR n 
1 415 VAL n 
1 416 PHE n 
1 417 VAL n 
1 418 ASP n 
1 419 PHE n 
1 420 ARG n 
1 421 THR n 
1 422 GLU n 
1 423 ASP n 
1 424 GLY n 
1 425 THR n 
1 426 ALA n 
1 427 ASN n 
1 428 ALA n 
1 429 GLY n 
1 430 SER n 
1 431 ASP n 
1 432 TYR n 
1 433 GLU n 
1 434 PHE n 
1 435 THR n 
1 436 GLU n 
1 437 GLY n 
1 438 THR n 
1 439 VAL n 
1 440 VAL n 
1 441 PHE n 
1 442 LYS n 
1 443 PRO n 
1 444 GLY n 
1 445 ASP n 
1 446 THR n 
1 447 GLN n 
1 448 LYS n 
1 449 GLU n 
1 450 ILE n 
1 451 ARG n 
1 452 VAL n 
1 453 GLY n 
1 454 ILE n 
1 455 ILE n 
1 456 ASP n 
1 457 ASP n 
1 458 ASP n 
1 459 ILE n 
1 460 PHE n 
1 461 GLU n 
1 462 GLU n 
1 463 ASP n 
1 464 GLU n 
1 465 ASN n 
1 466 PHE n 
1 467 LEU n 
1 468 VAL n 
1 469 HIS n 
1 470 LEU n 
1 471 SER n 
1 472 ASN n 
1 473 VAL n 
1 474 LYS n 
1 475 VAL n 
1 476 SER n 
1 477 SER n 
1 478 GLU n 
1 479 ALA n 
1 480 SER n 
1 481 GLU n 
1 482 ASP n 
1 483 GLY n 
1 484 ILE n 
1 485 LEU n 
1 486 GLU n 
1 487 ALA n 
1 488 ASN n 
1 489 HIS n 
1 490 VAL n 
1 491 SER n 
1 492 THR n 
1 493 LEU n 
1 494 ALA n 
1 495 CYS n 
1 496 LEU n 
1 497 GLY n 
1 498 SER n 
1 499 PRO n 
1 500 SER n 
1 501 THR n 
1 502 ALA n 
1 503 THR n 
1 504 VAL n 
1 505 THR n 
1 506 ILE n 
1 507 PHE n 
1 508 ASP n 
1 509 ASP n 
1 510 ASP n 
1 511 HIS n 
1 512 ALA n 
1 513 GLY n 
1 514 ILE n 
1 515 PHE n 
1 516 THR n 
1 517 PHE n 
1 518 GLU n 
1 519 GLU n 
1 520 PRO n 
1 521 VAL n 
1 522 THR n 
1 523 HIS n 
1 524 VAL n 
1 525 SER n 
1 526 GLU n 
1 527 SER n 
1 528 ILE n 
1 529 GLY n 
1 530 ILE n 
1 531 MET n 
1 532 GLU n 
1 533 VAL n 
1 534 LYS n 
1 535 VAL n 
1 536 LEU n 
1 537 ARG n 
1 538 THR n 
1 539 SER n 
1 540 GLY n 
1 541 ALA n 
1 542 ARG n 
1 543 GLY n 
1 544 ASN n 
1 545 VAL n 
1 546 ILE n 
1 547 VAL n 
1 548 PRO n 
1 549 TYR n 
1 550 LYS n 
1 551 THR n 
1 552 ILE n 
1 553 GLU n 
1 554 GLY n 
1 555 THR n 
1 556 ALA n 
1 557 ARG n 
1 558 GLY n 
1 559 GLY n 
1 560 GLY n 
1 561 GLU n 
1 562 ASP n 
1 563 PHE n 
1 564 GLU n 
1 565 ASP n 
1 566 THR n 
1 567 CYS n 
1 568 GLY n 
1 569 GLU n 
1 570 LEU n 
1 571 GLU n 
1 572 PHE n 
1 573 GLN n 
1 574 ASN n 
1 575 ASP n 
1 576 GLU n 
1 577 ILE n 
1 578 VAL n 
1 579 LYS n 
1 580 THR n 
1 581 ILE n 
1 582 SER n 
1 583 VAL n 
1 584 LYS n 
1 585 VAL n 
1 586 ILE n 
1 587 ASP n 
1 588 ASP n 
1 589 GLU n 
1 590 GLU n 
1 591 TYR n 
1 592 GLU n 
1 593 LYS n 
1 594 ASN n 
1 595 LYS n 
1 596 THR n 
1 597 PHE n 
1 598 PHE n 
1 599 LEU n 
1 600 GLU n 
1 601 ILE n 
1 602 GLY n 
1 603 GLU n 
1 604 PRO n 
1 605 ARG n 
1 606 LEU n 
1 607 VAL n 
1 608 GLU n 
1 609 MET n 
1 610 SER n 
1 611 GLU n 
1 612 LYS n 
1 613 LYS n 
1 614 ALA n 
1 615 LEU n 
1 616 LEU n 
1 617 LEU n 
1 618 ASN n 
1 619 GLU n 
1 620 LEU n 
1 621 GLY n 
1 622 GLY n 
1 623 PHE n 
1 624 THR n 
1 625 ILE n 
1 626 THR n 
1 627 GLY n 
1 628 LYS n 
1 629 TYR n 
1 630 LEU n 
1 631 PHE n 
1 632 GLY n 
1 633 GLN n 
1 634 PRO n 
1 635 VAL n 
1 636 PHE n 
1 637 ARG n 
1 638 LYS n 
1 639 VAL n 
1 640 HIS n 
1 641 ALA n 
1 642 ARG n 
1 643 GLU n 
1 644 HIS n 
1 645 PRO n 
1 646 ILE n 
1 647 LEU n 
1 648 SER n 
1 649 THR n 
1 650 VAL n 
1 651 ILE n 
1 652 THR n 
1 653 ILE n 
1 654 ALA n 
1 655 ASP n 
1 656 GLU n 
1 657 TYR n 
1 658 ASP n 
1 659 ASP n 
1 660 LYS n 
1 661 GLN n 
1 662 PRO n 
1 663 LEU n 
1 664 THR n 
1 665 SER n 
1 666 LYS n 
1 667 GLU n 
1 668 GLU n 
1 669 GLU n 
1 670 GLU n 
1 671 ARG n 
1 672 ARG n 
1 673 ILE n 
1 674 ALA n 
1 675 GLU n 
1 676 MET n 
1 677 GLY n 
1 678 ARG n 
1 679 PRO n 
1 680 ILE n 
1 681 LEU n 
1 682 GLY n 
1 683 GLU n 
1 684 HIS n 
1 685 THR n 
1 686 LYS n 
1 687 LEU n 
1 688 GLU n 
1 689 VAL n 
1 690 ILE n 
1 691 ILE n 
1 692 GLU n 
1 693 GLU n 
1 694 SER n 
1 695 TYR n 
1 696 GLU n 
1 697 PHE n 
1 698 LYS n 
1 699 SER n 
1 700 THR n 
1 701 VAL n 
1 702 ASP n 
1 703 LYS n 
1 704 LEU n 
1 705 ILE n 
1 706 LYS n 
1 707 LYS n 
1 708 THR n 
1 709 ASN n 
1 710 LEU n 
1 711 ALA n 
1 712 LEU n 
1 713 VAL n 
1 714 VAL n 
1 715 GLY n 
1 716 THR n 
1 717 ASN n 
1 718 SER n 
1 719 TRP n 
1 720 ARG n 
1 721 GLU n 
1 722 GLN n 
1 723 PHE n 
1 724 ILE n 
1 725 GLU n 
1 726 ALA n 
1 727 ILE n 
1 728 THR n 
1 729 VAL n 
1 730 SER n 
1 731 ALA n 
1 732 GLY n 
1 733 GLU n 
1 734 ASP n 
1 735 ASP n 
1 736 ASP n 
1 737 ASP n 
1 738 ASP n 
1 739 GLU n 
1 740 CYS n 
1 741 GLY n 
1 742 GLU n 
1 743 GLU n 
1 744 LYS n 
1 745 LEU n 
1 746 PRO n 
1 747 SER n 
1 748 CYS n 
1 749 PHE n 
1 750 ASP n 
1 751 TYR n 
1 752 VAL n 
1 753 MET n 
1 754 HIS n 
1 755 PHE n 
1 756 LEU n 
1 757 THR n 
1 758 VAL n 
1 759 PHE n 
1 760 TRP n 
1 761 LYS n 
1 762 VAL n 
1 763 LEU n 
1 764 PHE n 
1 765 ALA n 
1 766 PHE n 
1 767 VAL n 
1 768 PRO n 
1 769 PRO n 
1 770 THR n 
1 771 GLU n 
1 772 TYR n 
1 773 TRP n 
1 774 ASN n 
1 775 GLY n 
1 776 TRP n 
1 777 ALA n 
1 778 CYS n 
1 779 PHE n 
1 780 ILE n 
1 781 VAL n 
1 782 SER n 
1 783 ILE n 
1 784 LEU n 
1 785 MET n 
1 786 ILE n 
1 787 GLY n 
1 788 LEU n 
1 789 LEU n 
1 790 THR n 
1 791 ALA n 
1 792 PHE n 
1 793 ILE n 
1 794 GLY n 
1 795 ASP n 
1 796 LEU n 
1 797 ALA n 
1 798 SER n 
1 799 HIS n 
1 800 PHE n 
1 801 GLY n 
1 802 CYS n 
1 803 THR n 
1 804 ILE n 
1 805 GLY n 
1 806 LEU n 
1 807 LYS n 
1 808 ASP n 
1 809 SER n 
1 810 VAL n 
1 811 THR n 
1 812 ALA n 
1 813 VAL n 
1 814 VAL n 
1 815 PHE n 
1 816 VAL n 
1 817 ALA n 
1 818 LEU n 
1 819 GLY n 
1 820 THR n 
1 821 SER n 
1 822 VAL n 
1 823 PRO n 
1 824 ASP n 
1 825 THR n 
1 826 PHE n 
1 827 ALA n 
1 828 SER n 
1 829 LYS n 
1 830 VAL n 
1 831 ALA n 
1 832 ALA n 
1 833 THR n 
1 834 GLN n 
1 835 ASP n 
1 836 GLN n 
1 837 TYR n 
1 838 ALA n 
1 839 ASP n 
1 840 ALA n 
1 841 SER n 
1 842 ILE n 
1 843 GLY n 
1 844 ASN n 
1 845 VAL n 
1 846 THR n 
1 847 GLY n 
1 848 SER n 
1 849 ASN n 
1 850 ALA n 
1 851 VAL n 
1 852 ASN n 
1 853 VAL n 
1 854 PHE n 
1 855 LEU n 
1 856 GLY n 
1 857 ILE n 
1 858 GLY n 
1 859 VAL n 
1 860 ALA n 
1 861 TRP n 
1 862 SER n 
1 863 ILE n 
1 864 ALA n 
1 865 ALA n 
1 866 ILE n 
1 867 TYR n 
1 868 HIS n 
1 869 ALA n 
1 870 ALA n 
1 871 ASN n 
1 872 GLY n 
1 873 GLU n 
1 874 GLN n 
1 875 PHE n 
1 876 LYS n 
1 877 VAL n 
1 878 SER n 
1 879 PRO n 
1 880 GLY n 
1 881 THR n 
1 882 LEU n 
1 883 ALA n 
1 884 PHE n 
1 885 SER n 
1 886 VAL n 
1 887 THR n 
1 888 LEU n 
1 889 PHE n 
1 890 THR n 
1 891 ILE n 
1 892 PHE n 
1 893 ALA n 
1 894 PHE n 
1 895 ILE n 
1 896 ASN n 
1 897 VAL n 
1 898 GLY n 
1 899 VAL n 
1 900 LEU n 
1 901 LEU n 
1 902 TYR n 
1 903 ARG n 
1 904 ARG n 
1 905 ARG n 
1 906 PRO n 
1 907 GLU n 
1 908 ILE n 
1 909 GLY n 
1 910 GLY n 
1 911 GLU n 
1 912 LEU n 
1 913 GLY n 
1 914 GLY n 
1 915 PRO n 
1 916 ARG n 
1 917 THR n 
1 918 ALA n 
1 919 LYS n 
1 920 LEU n 
1 921 LEU n 
1 922 THR n 
1 923 SER n 
1 924 CYS n 
1 925 LEU n 
1 926 PHE n 
1 927 VAL n 
1 928 LEU n 
1 929 LEU n 
1 930 TRP n 
1 931 LEU n 
1 932 LEU n 
1 933 TYR n 
1 934 ILE n 
1 935 PHE n 
1 936 PHE n 
1 937 SER n 
1 938 SER n 
1 939 LEU n 
1 940 GLU n 
1 941 ALA n 
1 942 TYR n 
1 943 CYS n 
1 944 HIS n 
1 945 ILE n 
1 946 LYS n 
1 947 GLY n 
1 948 PHE n 
1 949 ALA n 
1 950 ALA n 
1 951 ALA n 
1 952 GLY n 
1 953 GLY n 
1 954 SER n 
1 955 TRP n 
1 956 SER n 
1 957 HIS n 
1 958 PRO n 
1 959 GLN n 
1 960 PHE n 
1 961 GLU n 
1 962 LYS n 
1 963 GLY n 
1 964 GLY n 
1 965 GLY n 
1 966 SER n 
1 967 GLY n 
1 968 GLY n 
1 969 GLY n 
1 970 SER n 
1 971 GLY n 
1 972 GLY n 
1 973 SER n 
1 974 ALA n 
1 975 TRP n 
1 976 SER n 
1 977 HIS n 
1 978 PRO n 
1 979 GLN n 
1 980 PHE n 
1 981 GLU n 
1 982 LYS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   982 
_entity_src_gen.gene_src_common_name               human 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'SLC8A1, CNC, NCX1' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     9606 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Homo sapiens' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     9606 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE ?                                                                'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE ?                                                                'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE ?                                                                'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ?                                                                'C4 H7 N O4'     
133.103 
CA  non-polymer         . 'CALCIUM ION' ?                                                                'Ca 2'           40.078  
CYS 'L-peptide linking' y CYSTEINE ?                                                                'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE ?                                                                'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ?                                                                'C5 H9 N O4'     
147.129 
GLY 'peptide linking'   y GLYCINE ?                                                                'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE ?                                                                'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking' y ISOLEUCINE ?                                                                'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE ?                                                                'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE ?                                                                'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE ?                                                                'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE ?                                                                'C9 H11 N O2'    165.189 
PIO non-polymer         . 
;[(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
;
'dioctanoyl l-alpha-phosphatidyl-d-myo-inositol 4,5-diphosphate' 'C25 H49 O19 P3' 746.566 
PRO 'L-peptide linking' y PROLINE ?                                                                'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE ?                                                                'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE ?                                                                'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN ?                                                                'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE ?                                                                'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE ?                                                                'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   -34 ?   ?   ?   A . n 
A 1 2   TYR 2   -33 ?   ?   ?   A . n 
A 1 3   ASN 3   -32 ?   ?   ?   A . n 
A 1 4   MET 4   -31 ?   ?   ?   A . n 
A 1 5   ARG 5   -30 ?   ?   ?   A . n 
A 1 6   ARG 6   -29 ?   ?   ?   A . n 
A 1 7   LEU 7   -28 ?   ?   ?   A . n 
A 1 8   SER 8   -27 ?   ?   ?   A . n 
A 1 9   LEU 9   -26 ?   ?   ?   A . n 
A 1 10  SER 10  -25 ?   ?   ?   A . n 
A 1 11  PRO 11  -24 ?   ?   ?   A . n 
A 1 12  THR 12  -23 ?   ?   ?   A . n 
A 1 13  PHE 13  -22 ?   ?   ?   A . n 
A 1 14  SER 14  -21 ?   ?   ?   A . n 
A 1 15  MET 15  -20 ?   ?   ?   A . n 
A 1 16  GLY 16  -19 ?   ?   ?   A . n 
A 1 17  PHE 17  -18 ?   ?   ?   A . n 
A 1 18  HIS 18  -17 ?   ?   ?   A . n 
A 1 19  LEU 19  -16 ?   ?   ?   A . n 
A 1 20  LEU 20  -15 ?   ?   ?   A . n 
A 1 21  VAL 21  -14 ?   ?   ?   A . n 
A 1 22  THR 22  -13 ?   ?   ?   A . n 
A 1 23  VAL 23  -12 ?   ?   ?   A . n 
A 1 24  SER 24  -11 ?   ?   ?   A . n 
A 1 25  LEU 25  -10 ?   ?   ?   A . n 
A 1 26  LEU 26  -9  ?   ?   ?   A . n 
A 1 27  PHE 27  -8  ?   ?   ?   A . n 
A 1 28  SER 28  -7  ?   ?   ?   A . n 
A 1 29  HIS 29  -6  ?   ?   ?   A . n 
A 1 30  VAL 30  -5  ?   ?   ?   A . n 
A 1 31  ASP 31  -4  ?   ?   ?   A . n 
A 1 32  HIS 32  -3  ?   ?   ?   A . n 
A 1 33  VAL 33  -2  ?   ?   ?   A . n 
A 1 34  ILE 34  -1  ?   ?   ?   A . n 
A 1 35  ALA 35  0   ?   ?   ?   A . n 
A 1 36  GLU 36  1   ?   ?   ?   A . n 
A 1 37  THR 37  2   ?   ?   ?   A . n 
A 1 38  GLU 38  3   ?   ?   ?   A . n 
A 1 39  MET 39  4   ?   ?   ?   A . n 
A 1 40  GLU 40  5   ?   ?   ?   A . n 
A 1 41  GLY 41  6   ?   ?   ?   A . n 
A 1 42  GLU 42  7   ?   ?   ?   A . n 
A 1 43  GLY 43  8   ?   ?   ?   A . n 
A 1 44  ASN 44  9   ?   ?   ?   A . n 
A 1 45  GLU 45  10  ?   ?   ?   A . n 
A 1 46  THR 46  11  ?   ?   ?   A . n 
A 1 47  GLY 47  12  ?   ?   ?   A . n 
A 1 48  GLU 48  13  ?   ?   ?   A . n 
A 1 49  CYS 49  14  ?   ?   ?   A . n 
A 1 50  THR 50  15  ?   ?   ?   A . n 
A 1 51  GLY 51  16  ?   ?   ?   A . n 
A 1 52  SER 52  17  17  SER SER A . n 
A 1 53  TYR 53  18  18  TYR TYR A . n 
A 1 54  TYR 54  19  19  TYR TYR A . n 
A 1 55  CYS 55  20  20  CYS CYS A . n 
A 1 56  LYS 56  21  21  LYS LYS A . n 
A 1 57  LYS 57  22  22  LYS LYS A . n 
A 1 58  GLY 58  23  23  GLY GLY A . n 
A 1 59  VAL 59  24  24  VAL VAL A . n 
A 1 60  ILE 60  25  25  ILE ILE A . n 
A 1 61  LEU 61  26  26  LEU LEU A . n 
A 1 62  PRO 62  27  27  PRO PRO A . n 
A 1 63  ILE 63  28  28  ILE ILE A . n 
A 1 64  TRP 64  29  29  TRP TRP A . n 
A 1 65  GLU 65  30  30  GLU GLU A . n 
A 1 66  PRO 66  31  31  PRO PRO A . n 
A 1 67  GLN 67  32  32  GLN GLN A . n 
A 1 68  ASP 68  33  33  ASP ASP A . n 
A 1 69  PRO 69  34  34  PRO PRO A . n 
A 1 70  SER 70  35  35  SER SER A . n 
A 1 71  PHE 71  36  36  PHE PHE A . n 
A 1 72  GLY 72  37  37  GLY GLY A . n 
A 1 73  ASP 73  38  38  ASP ASP A . n 
A 1 74  LYS 74  39  39  LYS LYS A . n 
A 1 75  ILE 75  40  40  ILE ILE A . n 
A 1 76  ALA 76  41  41  ALA ALA A . n 
A 1 77  ARG 77  42  42  ARG ARG A . n 
A 1 78  ALA 78  43  43  ALA ALA A . n 
A 1 79  THR 79  44  44  THR THR A . n 
A 1 80  VAL 80  45  45  VAL VAL A . n 
A 1 81  TYR 81  46  46  TYR TYR A . n 
A 1 82  PHE 82  47  47  PHE PHE A . n 
A 1 83  VAL 83  48  48  VAL VAL A . n 
A 1 84  ALA 84  49  49  ALA ALA A . n 
A 1 85  MET 85  50  50  MET MET A . n 
A 1 86  VAL 86  51  51  VAL VAL A . n 
A 1 87  TYR 87  52  52  TYR TYR A . n 
A 1 88  MET 88  53  53  MET MET A . n 
A 1 89  PHE 89  54  54  PHE PHE A . n 
A 1 90  LEU 90  55  55  LEU LEU A . n 
A 1 91  GLY 91  56  56  GLY GLY A . n 
A 1 92  VAL 92  57  57  VAL VAL A . n 
A 1 93  SER 93  58  58  SER SER A . n 
A 1 94  ILE 94  59  59  ILE ILE A . n 
A 1 95  ILE 95  60  60  ILE ILE A . n 
A 1 96  ALA 96  61  61  ALA ALA A . n 
A 1 97  ASP 97  62  62  ASP ASP A . n 
A 1 98  ARG 98  63  63  ARG ARG A . n 
A 1 99  PHE 99  64  64  PHE PHE A . n 
A 1 100 MET 100 65  65  MET MET A . n 
A 1 101 SER 101 66  66  SER SER A . n 
A 1 102 SER 102 67  67  SER SER A . n 
A 1 103 ILE 103 68  68  ILE ILE A . n 
A 1 104 GLU 104 69  69  GLU GLU A . n 
A 1 105 VAL 105 70  70  VAL VAL A . n 
A 1 106 ILE 106 71  71  ILE ILE A . n 
A 1 107 THR 107 72  72  THR THR A . n 
A 1 108 SER 108 73  73  SER SER A . n 
A 1 109 GLN 109 74  74  GLN GLN A . n 
A 1 110 GLU 110 75  75  GLU GLU A . n 
A 1 111 LYS 111 76  76  LYS LYS A . n 
A 1 112 GLU 112 77  77  GLU GLU A . n 
A 1 113 ILE 113 78  78  ILE ILE A . n 
A 1 114 THR 114 79  79  THR THR A . n 
A 1 115 ILE 115 80  80  ILE ILE A . n 
A 1 116 LYS 116 81  81  LYS LYS A . n 
A 1 117 LYS 117 82  82  LYS LYS A . n 
A 1 118 PRO 118 83  83  PRO PRO A . n 
A 1 119 ASN 119 84  84  ASN ASN A . n 
A 1 120 GLY 120 85  85  GLY GLY A . n 
A 1 121 GLU 121 86  86  GLU GLU A . n 
A 1 122 THR 122 87  87  THR THR A . n 
A 1 123 THR 123 88  88  THR THR A . n 
A 1 124 LYS 124 89  89  LYS LYS A . n 
A 1 125 THR 125 90  90  THR THR A . n 
A 1 126 THR 126 91  91  THR THR A . n 
A 1 127 VAL 127 92  92  VAL VAL A . n 
A 1 128 ARG 128 93  93  ARG ARG A . n 
A 1 129 ILE 129 94  94  ILE ILE A . n 
A 1 130 TRP 130 95  95  TRP TRP A . n 
A 1 131 ASN 131 96  96  ASN ASN A . n 
A 1 132 GLU 132 97  97  GLU GLU A . n 
A 1 133 THR 133 98  98  THR THR A . n 
A 1 134 VAL 134 99  99  VAL VAL A . n 
A 1 135 SER 135 100 100 SER SER A . n 
A 1 136 ASN 136 101 101 ASN ASN A . n 
A 1 137 LEU 137 102 102 LEU LEU A . n 
A 1 138 THR 138 103 103 THR THR A . n 
A 1 139 LEU 139 104 104 LEU LEU A . n 
A 1 140 MET 140 105 105 MET MET A . n 
A 1 141 ALA 141 106 106 ALA ALA A . n 
A 1 142 LEU 142 107 107 LEU LEU A . n 
A 1 143 GLY 143 108 108 GLY GLY A . n 
A 1 144 SER 144 109 109 SER SER A . n 
A 1 145 SER 145 110 110 SER SER A . n 
A 1 146 ALA 146 111 111 ALA ALA A . n 
A 1 147 PRO 147 112 112 PRO PRO A . n 
A 1 148 GLU 148 113 113 GLU GLU A . n 
A 1 149 ILE 149 114 114 ILE ILE A . n 
A 1 150 LEU 150 115 115 LEU LEU A . n 
A 1 151 LEU 151 116 116 LEU LEU A . n 
A 1 152 SER 152 117 117 SER SER A . n 
A 1 153 VAL 153 118 118 VAL VAL A . n 
A 1 154 ILE 154 119 119 ILE ILE A . n 
A 1 155 GLU 155 120 120 GLU GLU A . n 
A 1 156 VAL 156 121 121 VAL VAL A . n 
A 1 157 CYS 157 122 122 CYS CYS A . n 
A 1 158 GLY 158 123 123 GLY GLY A . n 
A 1 159 HIS 159 124 124 HIS HIS A . n 
A 1 160 ASN 160 125 125 ASN ASN A . n 
A 1 161 PHE 161 126 126 PHE PHE A . n 
A 1 162 THR 162 127 127 THR THR A . n 
A 1 163 ALA 163 128 128 ALA ALA A . n 
A 1 164 GLY 164 129 129 GLY GLY A . n 
A 1 165 ASP 165 130 130 ASP ASP A . n 
A 1 166 LEU 166 131 131 LEU LEU A . n 
A 1 167 GLY 167 132 132 GLY GLY A . n 
A 1 168 PRO 168 133 133 PRO PRO A . n 
A 1 169 SER 169 134 134 SER SER A . n 
A 1 170 THR 170 135 135 THR THR A . n 
A 1 171 ILE 171 136 136 ILE ILE A . n 
A 1 172 VAL 172 137 137 VAL VAL A . n 
A 1 173 GLY 173 138 138 GLY GLY A . n 
A 1 174 SER 174 139 139 SER SER A . n 
A 1 175 ALA 175 140 140 ALA ALA A . n 
A 1 176 ALA 176 141 141 ALA ALA A . n 
A 1 177 PHE 177 142 142 PHE PHE A . n 
A 1 178 ASN 178 143 143 ASN ASN A . n 
A 1 179 MET 179 144 144 MET MET A . n 
A 1 180 PHE 180 145 145 PHE PHE A . n 
A 1 181 ILE 181 146 146 ILE ILE A . n 
A 1 182 ILE 182 147 147 ILE ILE A . n 
A 1 183 ILE 183 148 148 ILE ILE A . n 
A 1 184 ALA 184 149 149 ALA ALA A . n 
A 1 185 LEU 185 150 150 LEU LEU A . n 
A 1 186 CYS 186 151 151 CYS CYS A . n 
A 1 187 VAL 187 152 152 VAL VAL A . n 
A 1 188 TYR 188 153 153 TYR TYR A . n 
A 1 189 VAL 189 154 154 VAL VAL A . n 
A 1 190 VAL 190 155 155 VAL VAL A . n 
A 1 191 PRO 191 156 156 PRO PRO A . n 
A 1 192 ASP 192 157 157 ASP ASP A . n 
A 1 193 GLY 193 158 158 GLY GLY A . n 
A 1 194 GLU 194 159 159 GLU GLU A . n 
A 1 195 THR 195 160 160 THR THR A . n 
A 1 196 ARG 196 161 161 ARG ARG A . n 
A 1 197 LYS 197 162 162 LYS LYS A . n 
A 1 198 ILE 198 163 163 ILE ILE A . n 
A 1 199 LYS 199 164 164 LYS LYS A . n 
A 1 200 HIS 200 165 165 HIS HIS A . n 
A 1 201 LEU 201 166 166 LEU LEU A . n 
A 1 202 ARG 202 167 167 ARG ARG A . n 
A 1 203 VAL 203 168 168 VAL VAL A . n 
A 1 204 PHE 204 169 169 PHE PHE A . n 
A 1 205 PHE 205 170 170 PHE PHE A . n 
A 1 206 VAL 206 171 171 VAL VAL A . n 
A 1 207 THR 207 172 172 THR THR A . n 
A 1 208 ALA 208 173 173 ALA ALA A . n 
A 1 209 ALA 209 174 174 ALA ALA A . n 
A 1 210 TRP 210 175 175 TRP TRP A . n 
A 1 211 SER 211 176 176 SER SER A . n 
A 1 212 ILE 212 177 177 ILE ILE A . n 
A 1 213 PHE 213 178 178 PHE PHE A . n 
A 1 214 ALA 214 179 179 ALA ALA A . n 
A 1 215 TYR 215 180 180 TYR TYR A . n 
A 1 216 THR 216 181 181 THR THR A . n 
A 1 217 TRP 217 182 182 TRP TRP A . n 
A 1 218 LEU 218 183 183 LEU LEU A . n 
A 1 219 TYR 219 184 184 TYR TYR A . n 
A 1 220 ILE 220 185 185 ILE ILE A . n 
A 1 221 ILE 221 186 186 ILE ILE A . n 
A 1 222 LEU 222 187 187 LEU LEU A . n 
A 1 223 SER 223 188 188 SER SER A . n 
A 1 224 VAL 224 189 189 VAL VAL A . n 
A 1 225 ILE 225 190 190 ILE ILE A . n 
A 1 226 SER 226 191 191 SER SER A . n 
A 1 227 PRO 227 192 192 PRO PRO A . n 
A 1 228 GLY 228 193 193 GLY GLY A . n 
A 1 229 VAL 229 194 194 VAL VAL A . n 
A 1 230 VAL 230 195 195 VAL VAL A . n 
A 1 231 GLU 231 196 196 GLU GLU A . n 
A 1 232 VAL 232 197 197 VAL VAL A . n 
A 1 233 TRP 233 198 198 TRP TRP A . n 
A 1 234 GLU 234 199 199 GLU GLU A . n 
A 1 235 GLY 235 200 200 GLY GLY A . n 
A 1 236 LEU 236 201 201 LEU LEU A . n 
A 1 237 LEU 237 202 202 LEU LEU A . n 
A 1 238 THR 238 203 203 THR THR A . n 
A 1 239 PHE 239 204 204 PHE PHE A . n 
A 1 240 PHE 240 205 205 PHE PHE A . n 
A 1 241 PHE 241 206 206 PHE PHE A . n 
A 1 242 PHE 242 207 207 PHE PHE A . n 
A 1 243 PRO 243 208 208 PRO PRO A . n 
A 1 244 ILE 244 209 209 ILE ILE A . n 
A 1 245 CYS 245 210 210 CYS CYS A . n 
A 1 246 VAL 246 211 211 VAL VAL A . n 
A 1 247 VAL 247 212 212 VAL VAL A . n 
A 1 248 PHE 248 213 213 PHE PHE A . n 
A 1 249 ALA 249 214 214 ALA ALA A . n 
A 1 250 TRP 250 215 215 TRP TRP A . n 
A 1 251 VAL 251 216 216 VAL VAL A . n 
A 1 252 ALA 252 217 217 ALA ALA A . n 
A 1 253 ASP 253 218 218 ASP ASP A . n 
A 1 254 ARG 254 219 219 ARG ARG A . n 
A 1 255 ARG 255 220 220 ARG ARG A . n 
A 1 256 LEU 256 221 221 LEU LEU A . n 
A 1 257 LEU 257 222 222 LEU LEU A . n 
A 1 258 PHE 258 223 223 PHE PHE A . n 
A 1 259 TYR 259 224 224 TYR TYR A . n 
A 1 260 LYS 260 225 225 LYS LYS A . n 
A 1 261 TYR 261 226 226 TYR TYR A . n 
A 1 262 VAL 262 227 227 VAL VAL A . n 
A 1 263 TYR 263 228 228 TYR TYR A . n 
A 1 264 LYS 264 229 229 LYS LYS A . n 
A 1 265 ARG 265 230 230 ARG ARG A . n 
A 1 266 TYR 266 231 231 TYR TYR A . n 
A 1 267 ARG 267 232 232 ARG ARG A . n 
A 1 268 ALA 268 233 233 ALA ALA A . n 
A 1 269 GLY 269 234 234 GLY GLY A . n 
A 1 270 LYS 270 235 235 LYS LYS A . n 
A 1 271 GLN 271 236 236 GLN GLN A . n 
A 1 272 ARG 272 237 237 ARG ARG A . n 
A 1 273 GLY 273 238 238 GLY GLY A . n 
A 1 274 MET 274 239 239 MET MET A . n 
A 1 275 ILE 275 240 240 ILE ILE A . n 
A 1 276 ILE 276 241 241 ILE ILE A . n 
A 1 277 GLU 277 242 242 GLU GLU A . n 
A 1 278 HIS 278 243 243 HIS HIS A . n 
A 1 279 GLU 279 244 244 GLU GLU A . n 
A 1 280 GLY 280 245 245 GLY GLY A . n 
A 1 281 ASP 281 246 246 ASP ASP A . n 
A 1 282 ARG 282 247 247 ARG ARG A . n 
A 1 283 PRO 283 273 ?   ?   ?   A . n 
A 1 284 SER 284 274 ?   ?   ?   A . n 
A 1 285 SER 285 275 ?   ?   ?   A . n 
A 1 286 LYS 286 276 ?   ?   ?   A . n 
A 1 287 THR 287 277 ?   ?   ?   A . n 
A 1 288 GLU 288 278 ?   ?   ?   A . n 
A 1 289 ILE 289 279 ?   ?   ?   A . n 
A 1 290 GLU 290 280 ?   ?   ?   A . n 
A 1 291 MET 291 281 ?   ?   ?   A . n 
A 1 292 ASP 292 282 ?   ?   ?   A . n 
A 1 293 GLY 293 283 ?   ?   ?   A . n 
A 1 294 LYS 294 284 ?   ?   ?   A . n 
A 1 295 VAL 295 285 ?   ?   ?   A . n 
A 1 296 VAL 296 286 ?   ?   ?   A . n 
A 1 297 ASN 297 287 ?   ?   ?   A . n 
A 1 298 SER 298 288 ?   ?   ?   A . n 
A 1 299 HIS 299 289 ?   ?   ?   A . n 
A 1 300 VAL 300 290 ?   ?   ?   A . n 
A 1 301 GLU 301 291 ?   ?   ?   A . n 
A 1 302 ASN 302 292 ?   ?   ?   A . n 
A 1 303 PHE 303 293 ?   ?   ?   A . n 
A 1 304 LEU 304 294 ?   ?   ?   A . n 
A 1 305 ASP 305 295 ?   ?   ?   A . n 
A 1 306 GLY 306 296 ?   ?   ?   A . n 
A 1 307 ALA 307 297 ?   ?   ?   A . n 
A 1 308 LEU 308 298 ?   ?   ?   A . n 
A 1 309 VAL 309 299 ?   ?   ?   A . n 
A 1 310 LEU 310 300 ?   ?   ?   A . n 
A 1 311 GLU 311 301 ?   ?   ?   A . n 
A 1 312 VAL 312 302 ?   ?   ?   A . n 
A 1 313 ASP 313 303 ?   ?   ?   A . n 
A 1 314 GLU 314 304 ?   ?   ?   A . n 
A 1 315 ARG 315 305 ?   ?   ?   A . n 
A 1 316 ASP 316 306 ?   ?   ?   A . n 
A 1 317 GLN 317 307 ?   ?   ?   A . n 
A 1 318 ASP 318 308 ?   ?   ?   A . n 
A 1 319 ASP 319 309 ?   ?   ?   A . n 
A 1 320 GLU 320 310 ?   ?   ?   A . n 
A 1 321 GLU 321 311 ?   ?   ?   A . n 
A 1 322 ALA 322 312 ?   ?   ?   A . n 
A 1 323 ARG 323 313 ?   ?   ?   A . n 
A 1 324 ARG 324 314 ?   ?   ?   A . n 
A 1 325 GLU 325 315 ?   ?   ?   A . n 
A 1 326 MET 326 316 ?   ?   ?   A . n 
A 1 327 ALA 327 317 ?   ?   ?   A . n 
A 1 328 ARG 328 318 ?   ?   ?   A . n 
A 1 329 ILE 329 319 ?   ?   ?   A . n 
A 1 330 LEU 330 320 ?   ?   ?   A . n 
A 1 331 LYS 331 321 ?   ?   ?   A . n 
A 1 332 GLU 332 322 ?   ?   ?   A . n 
A 1 333 LEU 333 323 ?   ?   ?   A . n 
A 1 334 LYS 334 324 ?   ?   ?   A . n 
A 1 335 GLN 335 325 ?   ?   ?   A . n 
A 1 336 LYS 336 326 ?   ?   ?   A . n 
A 1 337 HIS 337 327 ?   ?   ?   A . n 
A 1 338 PRO 338 328 ?   ?   ?   A . n 
A 1 339 ASP 339 329 ?   ?   ?   A . n 
A 1 340 LYS 340 330 ?   ?   ?   A . n 
A 1 341 GLU 341 331 ?   ?   ?   A . n 
A 1 342 ILE 342 332 ?   ?   ?   A . n 
A 1 343 GLU 343 333 ?   ?   ?   A . n 
A 1 344 GLN 344 334 ?   ?   ?   A . n 
A 1 345 LEU 345 335 ?   ?   ?   A . n 
A 1 346 ILE 346 336 ?   ?   ?   A . n 
A 1 347 GLU 347 337 ?   ?   ?   A . n 
A 1 348 LEU 348 338 ?   ?   ?   A . n 
A 1 349 ALA 349 339 ?   ?   ?   A . n 
A 1 350 ASN 350 340 ?   ?   ?   A . n 
A 1 351 TYR 351 341 ?   ?   ?   A . n 
A 1 352 GLN 352 342 ?   ?   ?   A . n 
A 1 353 VAL 353 343 ?   ?   ?   A . n 
A 1 354 LEU 354 344 ?   ?   ?   A . n 
A 1 355 SER 355 345 ?   ?   ?   A . n 
A 1 356 GLN 356 346 ?   ?   ?   A . n 
A 1 357 GLN 357 347 ?   ?   ?   A . n 
A 1 358 GLN 358 348 ?   ?   ?   A . n 
A 1 359 LYS 359 349 ?   ?   ?   A . n 
A 1 360 SER 360 350 ?   ?   ?   A . n 
A 1 361 ARG 361 351 ?   ?   ?   A . n 
A 1 362 ALA 362 352 ?   ?   ?   A . n 
A 1 363 PHE 363 353 ?   ?   ?   A . n 
A 1 364 TYR 364 354 ?   ?   ?   A . n 
A 1 365 ARG 365 355 ?   ?   ?   A . n 
A 1 366 ILE 366 356 ?   ?   ?   A . n 
A 1 367 GLN 367 357 ?   ?   ?   A . n 
A 1 368 ALA 368 358 ?   ?   ?   A . n 
A 1 369 THR 369 359 ?   ?   ?   A . n 
A 1 370 ARG 370 360 ?   ?   ?   A . n 
A 1 371 LEU 371 361 ?   ?   ?   A . n 
A 1 372 MET 372 362 ?   ?   ?   A . n 
A 1 373 THR 373 363 ?   ?   ?   A . n 
A 1 374 GLY 374 364 ?   ?   ?   A . n 
A 1 375 ALA 375 365 ?   ?   ?   A . n 
A 1 376 THR 376 366 ?   ?   ?   A . n 
A 1 377 GLU 377 367 ?   ?   ?   A . n 
A 1 378 ASN 378 368 ?   ?   ?   A . n 
A 1 379 ASP 379 369 ?   ?   ?   A . n 
A 1 380 PRO 380 370 370 PRO PRO A . n 
A 1 381 VAL 381 371 371 VAL VAL A . n 
A 1 382 SER 382 372 372 SER SER A . n 
A 1 383 LYS 383 373 373 LYS LYS A . n 
A 1 384 ILE 384 374 374 ILE ILE A . n 
A 1 385 PHE 385 375 375 PHE PHE A . n 
A 1 386 PHE 386 376 376 PHE PHE A . n 
A 1 387 GLU 387 377 377 GLU GLU A . n 
A 1 388 GLN 388 378 378 GLN GLN A . n 
A 1 389 GLY 389 379 379 GLY GLY A . n 
A 1 390 THR 390 380 380 THR THR A . n 
A 1 391 TYR 391 381 381 TYR TYR A . n 
A 1 392 GLN 392 382 382 GLN GLN A . n 
A 1 393 CYS 393 383 383 CYS CYS A . n 
A 1 394 LEU 394 384 384 LEU LEU A . n 
A 1 395 GLU 395 385 385 GLU GLU A . n 
A 1 396 ASN 396 386 386 ASN ASN A . n 
A 1 397 CYS 397 387 387 CYS CYS A . n 
A 1 398 GLY 398 388 388 GLY GLY A . n 
A 1 399 THR 399 389 389 THR THR A . n 
A 1 400 VAL 400 390 390 VAL VAL A . n 
A 1 401 ALA 401 391 391 ALA ALA A . n 
A 1 402 LEU 402 392 392 LEU LEU A . n 
A 1 403 THR 403 393 393 THR THR A . n 
A 1 404 ILE 404 394 394 ILE ILE A . n 
A 1 405 ILE 405 395 395 ILE ILE A . n 
A 1 406 ARG 406 396 396 ARG ARG A . n 
A 1 407 ARG 407 397 397 ARG ARG A . n 
A 1 408 GLY 408 398 398 GLY GLY A . n 
A 1 409 GLY 409 399 399 GLY GLY A . n 
A 1 410 ASP 410 400 400 ASP ASP A . n 
A 1 411 LEU 411 401 401 LEU LEU A . n 
A 1 412 THR 412 402 402 THR THR A . n 
A 1 413 ASN 413 403 403 ASN ASN A . n 
A 1 414 THR 414 404 404 THR THR A . n 
A 1 415 VAL 415 405 405 VAL VAL A . n 
A 1 416 PHE 416 406 406 PHE PHE A . n 
A 1 417 VAL 417 407 407 VAL VAL A . n 
A 1 418 ASP 418 408 408 ASP ASP A . n 
A 1 419 PHE 419 409 409 PHE PHE A . n 
A 1 420 ARG 420 410 410 ARG ARG A . n 
A 1 421 THR 421 411 411 THR THR A . n 
A 1 422 GLU 422 412 412 GLU GLU A . n 
A 1 423 ASP 423 413 413 ASP ASP A . n 
A 1 424 GLY 424 414 414 GLY GLY A . n 
A 1 425 THR 425 415 415 THR THR A . n 
A 1 426 ALA 426 416 416 ALA ALA A . n 
A 1 427 ASN 427 417 417 ASN ASN A . n 
A 1 428 ALA 428 418 418 ALA ALA A . n 
A 1 429 GLY 429 419 419 GLY GLY A . n 
A 1 430 SER 430 420 420 SER SER A . n 
A 1 431 ASP 431 421 421 ASP ASP A . n 
A 1 432 TYR 432 422 422 TYR TYR A . n 
A 1 433 GLU 433 423 423 GLU GLU A . n 
A 1 434 PHE 434 424 424 PHE PHE A . n 
A 1 435 THR 435 425 425 THR THR A . n 
A 1 436 GLU 436 426 426 GLU GLU A . n 
A 1 437 GLY 437 427 427 GLY GLY A . n 
A 1 438 THR 438 428 428 THR THR A . n 
A 1 439 VAL 439 429 429 VAL VAL A . n 
A 1 440 VAL 440 430 430 VAL VAL A . n 
A 1 441 PHE 441 431 431 PHE PHE A . n 
A 1 442 LYS 442 432 432 LYS LYS A . n 
A 1 443 PRO 443 433 433 PRO PRO A . n 
A 1 444 GLY 444 434 434 GLY GLY A . n 
A 1 445 ASP 445 435 435 ASP ASP A . n 
A 1 446 THR 446 436 436 THR THR A . n 
A 1 447 GLN 447 437 437 GLN GLN A . n 
A 1 448 LYS 448 438 438 LYS LYS A . n 
A 1 449 GLU 449 439 439 GLU GLU A . n 
A 1 450 ILE 450 440 440 ILE ILE A . n 
A 1 451 ARG 451 441 441 ARG ARG A . n 
A 1 452 VAL 452 442 442 VAL VAL A . n 
A 1 453 GLY 453 443 443 GLY GLY A . n 
A 1 454 ILE 454 444 444 ILE ILE A . n 
A 1 455 ILE 455 445 445 ILE ILE A . n 
A 1 456 ASP 456 446 446 ASP ASP A . n 
A 1 457 ASP 457 447 447 ASP ASP A . n 
A 1 458 ASP 458 448 448 ASP ASP A . n 
A 1 459 ILE 459 449 449 ILE ILE A . n 
A 1 460 PHE 460 450 450 PHE PHE A . n 
A 1 461 GLU 461 451 451 GLU GLU A . n 
A 1 462 GLU 462 452 452 GLU GLU A . n 
A 1 463 ASP 463 453 453 ASP ASP A . n 
A 1 464 GLU 464 454 454 GLU GLU A . n 
A 1 465 ASN 465 455 455 ASN ASN A . n 
A 1 466 PHE 466 456 456 PHE PHE A . n 
A 1 467 LEU 467 457 457 LEU LEU A . n 
A 1 468 VAL 468 458 458 VAL VAL A . n 
A 1 469 HIS 469 459 459 HIS HIS A . n 
A 1 470 LEU 470 460 460 LEU LEU A . n 
A 1 471 SER 471 461 461 SER SER A . n 
A 1 472 ASN 472 462 462 ASN ASN A . n 
A 1 473 VAL 473 463 463 VAL VAL A . n 
A 1 474 LYS 474 464 464 LYS LYS A . n 
A 1 475 VAL 475 465 465 VAL VAL A . n 
A 1 476 SER 476 466 466 SER SER A . n 
A 1 477 SER 477 467 467 SER SER A . n 
A 1 478 GLU 478 468 ?   ?   ?   A . n 
A 1 479 ALA 479 469 ?   ?   ?   A . n 
A 1 480 SER 480 470 ?   ?   ?   A . n 
A 1 481 GLU 481 471 ?   ?   ?   A . n 
A 1 482 ASP 482 472 ?   ?   ?   A . n 
A 1 483 GLY 483 473 ?   ?   ?   A . n 
A 1 484 ILE 484 474 ?   ?   ?   A . n 
A 1 485 LEU 485 475 ?   ?   ?   A . n 
A 1 486 GLU 486 476 ?   ?   ?   A . n 
A 1 487 ALA 487 477 ?   ?   ?   A . n 
A 1 488 ASN 488 478 ?   ?   ?   A . n 
A 1 489 HIS 489 479 ?   ?   ?   A . n 
A 1 490 VAL 490 480 ?   ?   ?   A . n 
A 1 491 SER 491 481 ?   ?   ?   A . n 
A 1 492 THR 492 482 482 THR THR A . n 
A 1 493 LEU 493 483 483 LEU LEU A . n 
A 1 494 ALA 494 484 484 ALA ALA A . n 
A 1 495 CYS 495 485 485 CYS CYS A . n 
A 1 496 LEU 496 486 486 LEU LEU A . n 
A 1 497 GLY 497 487 487 GLY GLY A . n 
A 1 498 SER 498 488 488 SER SER A . n 
A 1 499 PRO 499 489 489 PRO PRO A . n 
A 1 500 SER 500 490 490 SER SER A . n 
A 1 501 THR 501 491 491 THR THR A . n 
A 1 502 ALA 502 492 492 ALA ALA A . n 
A 1 503 THR 503 493 493 THR THR A . n 
A 1 504 VAL 504 494 494 VAL VAL A . n 
A 1 505 THR 505 495 495 THR THR A . n 
A 1 506 ILE 506 496 496 ILE ILE A . n 
A 1 507 PHE 507 497 497 PHE PHE A . n 
A 1 508 ASP 508 498 498 ASP ASP A . n 
A 1 509 ASP 509 499 499 ASP ASP A . n 
A 1 510 ASP 510 500 500 ASP ASP A . n 
A 1 511 HIS 511 501 501 HIS HIS A . n 
A 1 512 ALA 512 502 502 ALA ALA A . n 
A 1 513 GLY 513 503 503 GLY GLY A . n 
A 1 514 ILE 514 504 504 ILE ILE A . n 
A 1 515 PHE 515 505 505 PHE PHE A . n 
A 1 516 THR 516 506 506 THR THR A . n 
A 1 517 PHE 517 507 507 PHE PHE A . n 
A 1 518 GLU 518 508 508 GLU GLU A . n 
A 1 519 GLU 519 509 509 GLU GLU A . n 
A 1 520 PRO 520 510 510 PRO PRO A . n 
A 1 521 VAL 521 511 511 VAL VAL A . n 
A 1 522 THR 522 512 512 THR THR A . n 
A 1 523 HIS 523 513 513 HIS HIS A . n 
A 1 524 VAL 524 514 514 VAL VAL A . n 
A 1 525 SER 525 515 515 SER SER A . n 
A 1 526 GLU 526 516 516 GLU GLU A . n 
A 1 527 SER 527 517 517 SER SER A . n 
A 1 528 ILE 528 518 518 ILE ILE A . n 
A 1 529 GLY 529 519 519 GLY GLY A . n 
A 1 530 ILE 530 520 520 ILE ILE A . n 
A 1 531 MET 531 521 521 MET MET A . n 
A 1 532 GLU 532 522 522 GLU GLU A . n 
A 1 533 VAL 533 523 523 VAL VAL A . n 
A 1 534 LYS 534 524 524 LYS LYS A . n 
A 1 535 VAL 535 525 525 VAL VAL A . n 
A 1 536 LEU 536 526 526 LEU LEU A . n 
A 1 537 ARG 537 527 527 ARG ARG A . n 
A 1 538 THR 538 528 528 THR THR A . n 
A 1 539 SER 539 529 529 SER SER A . n 
A 1 540 GLY 540 530 530 GLY GLY A . n 
A 1 541 ALA 541 531 531 ALA ALA A . n 
A 1 542 ARG 542 532 532 ARG ARG A . n 
A 1 543 GLY 543 533 533 GLY GLY A . n 
A 1 544 ASN 544 534 534 ASN ASN A . n 
A 1 545 VAL 545 535 535 VAL VAL A . n 
A 1 546 ILE 546 536 536 ILE ILE A . n 
A 1 547 VAL 547 537 537 VAL VAL A . n 
A 1 548 PRO 548 538 538 PRO PRO A . n 
A 1 549 TYR 549 539 539 TYR TYR A . n 
A 1 550 LYS 550 540 540 LYS LYS A . n 
A 1 551 THR 551 541 541 THR THR A . n 
A 1 552 ILE 552 542 542 ILE ILE A . n 
A 1 553 GLU 553 543 543 GLU GLU A . n 
A 1 554 GLY 554 544 544 GLY GLY A . n 
A 1 555 THR 555 545 545 THR THR A . n 
A 1 556 ALA 556 546 546 ALA ALA A . n 
A 1 557 ARG 557 547 547 ARG ARG A . n 
A 1 558 GLY 558 548 548 GLY GLY A . n 
A 1 559 GLY 559 549 549 GLY GLY A . n 
A 1 560 GLY 560 550 550 GLY GLY A . n 
A 1 561 GLU 561 551 551 GLU GLU A . n 
A 1 562 ASP 562 552 552 ASP ASP A . n 
A 1 563 PHE 563 553 553 PHE PHE A . n 
A 1 564 GLU 564 554 554 GLU GLU A . n 
A 1 565 ASP 565 555 555 ASP ASP A . n 
A 1 566 THR 566 556 556 THR THR A . n 
A 1 567 CYS 567 557 557 CYS CYS A . n 
A 1 568 GLY 568 558 558 GLY GLY A . n 
A 1 569 GLU 569 559 559 GLU GLU A . n 
A 1 570 LEU 570 560 560 LEU LEU A . n 
A 1 571 GLU 571 561 561 GLU GLU A . n 
A 1 572 PHE 572 562 562 PHE PHE A . n 
A 1 573 GLN 573 563 563 GLN GLN A . n 
A 1 574 ASN 574 564 564 ASN ASN A . n 
A 1 575 ASP 575 565 565 ASP ASP A . n 
A 1 576 GLU 576 566 566 GLU GLU A . n 
A 1 577 ILE 577 567 567 ILE ILE A . n 
A 1 578 VAL 578 568 568 VAL VAL A . n 
A 1 579 LYS 579 569 569 LYS LYS A . n 
A 1 580 THR 580 570 570 THR THR A . n 
A 1 581 ILE 581 571 571 ILE ILE A . n 
A 1 582 SER 582 572 572 SER SER A . n 
A 1 583 VAL 583 573 573 VAL VAL A . n 
A 1 584 LYS 584 574 574 LYS LYS A . n 
A 1 585 VAL 585 575 575 VAL VAL A . n 
A 1 586 ILE 586 576 576 ILE ILE A . n 
A 1 587 ASP 587 577 577 ASP ASP A . n 
A 1 588 ASP 588 578 578 ASP ASP A . n 
A 1 589 GLU 589 579 579 GLU GLU A . n 
A 1 590 GLU 590 580 580 GLU GLU A . n 
A 1 591 TYR 591 581 581 TYR TYR A . n 
A 1 592 GLU 592 582 582 GLU GLU A . n 
A 1 593 LYS 593 583 583 LYS LYS A . n 
A 1 594 ASN 594 584 584 ASN ASN A . n 
A 1 595 LYS 595 585 585 LYS LYS A . n 
A 1 596 THR 596 586 586 THR THR A . n 
A 1 597 PHE 597 587 587 PHE PHE A . n 
A 1 598 PHE 598 588 588 PHE PHE A . n 
A 1 599 LEU 599 589 589 LEU LEU A . n 
A 1 600 GLU 600 590 590 GLU GLU A . n 
A 1 601 ILE 601 591 591 ILE ILE A . n 
A 1 602 GLY 602 592 592 GLY GLY A . n 
A 1 603 GLU 603 593 593 GLU GLU A . n 
A 1 604 PRO 604 594 594 PRO PRO A . n 
A 1 605 ARG 605 595 595 ARG ARG A . n 
A 1 606 LEU 606 596 596 LEU LEU A . n 
A 1 607 VAL 607 597 597 VAL VAL A . n 
A 1 608 GLU 608 598 598 GLU GLU A . n 
A 1 609 MET 609 599 599 MET MET A . n 
A 1 610 SER 610 600 600 SER SER A . n 
A 1 611 GLU 611 601 601 GLU GLU A . n 
A 1 612 LYS 612 602 602 LYS LYS A . n 
A 1 613 LYS 613 603 603 LYS LYS A . n 
A 1 614 ALA 614 604 604 ALA ALA A . n 
A 1 615 LEU 615 605 605 LEU LEU A . n 
A 1 616 LEU 616 606 606 LEU LEU A . n 
A 1 617 LEU 617 607 607 LEU LEU A . n 
A 1 618 ASN 618 608 608 ASN ASN A . n 
A 1 619 GLU 619 609 609 GLU GLU A . n 
A 1 620 LEU 620 610 610 LEU LEU A . n 
A 1 621 GLY 621 611 611 GLY GLY A . n 
A 1 622 GLY 622 612 612 GLY GLY A . n 
A 1 623 PHE 623 613 613 PHE PHE A . n 
A 1 624 THR 624 614 614 THR THR A . n 
A 1 625 ILE 625 615 615 ILE ILE A . n 
A 1 626 THR 626 616 616 THR THR A . n 
A 1 627 GLY 627 617 617 GLY GLY A . n 
A 1 628 LYS 628 618 618 LYS LYS A . n 
A 1 629 TYR 629 619 619 TYR TYR A . n 
A 1 630 LEU 630 620 620 LEU LEU A . n 
A 1 631 PHE 631 621 621 PHE PHE A . n 
A 1 632 GLY 632 622 622 GLY GLY A . n 
A 1 633 GLN 633 623 623 GLN GLN A . n 
A 1 634 PRO 634 624 624 PRO PRO A . n 
A 1 635 VAL 635 625 625 VAL VAL A . n 
A 1 636 PHE 636 626 626 PHE PHE A . n 
A 1 637 ARG 637 627 627 ARG ARG A . n 
A 1 638 LYS 638 628 628 LYS LYS A . n 
A 1 639 VAL 639 629 629 VAL VAL A . n 
A 1 640 HIS 640 630 630 HIS HIS A . n 
A 1 641 ALA 641 631 631 ALA ALA A . n 
A 1 642 ARG 642 632 632 ARG ARG A . n 
A 1 643 GLU 643 633 633 GLU GLU A . n 
A 1 644 HIS 644 634 634 HIS HIS A . n 
A 1 645 PRO 645 635 635 PRO PRO A . n 
A 1 646 ILE 646 636 636 ILE ILE A . n 
A 1 647 LEU 647 637 637 LEU LEU A . n 
A 1 648 SER 648 638 638 SER SER A . n 
A 1 649 THR 649 639 639 THR THR A . n 
A 1 650 VAL 650 640 640 VAL VAL A . n 
A 1 651 ILE 651 641 641 ILE ILE A . n 
A 1 652 THR 652 642 642 THR THR A . n 
A 1 653 ILE 653 643 643 ILE ILE A . n 
A 1 654 ALA 654 644 644 ALA ALA A . n 
A 1 655 ASP 655 645 ?   ?   ?   A . n 
A 1 656 GLU 656 646 ?   ?   ?   A . n 
A 1 657 TYR 657 647 ?   ?   ?   A . n 
A 1 658 ASP 658 648 ?   ?   ?   A . n 
A 1 659 ASP 659 649 ?   ?   ?   A . n 
A 1 660 LYS 660 650 ?   ?   ?   A . n 
A 1 661 GLN 661 651 ?   ?   ?   A . n 
A 1 662 PRO 662 652 652 PRO PRO A . n 
A 1 663 LEU 663 653 653 LEU LEU A . n 
A 1 664 THR 664 654 654 THR THR A . n 
A 1 665 SER 665 655 655 SER SER A . n 
A 1 666 LYS 666 656 656 LYS LYS A . n 
A 1 667 GLU 667 657 657 GLU GLU A . n 
A 1 668 GLU 668 658 658 GLU GLU A . n 
A 1 669 GLU 669 659 659 GLU GLU A . n 
A 1 670 GLU 670 660 660 GLU GLU A . n 
A 1 671 ARG 671 661 661 ARG ARG A . n 
A 1 672 ARG 672 662 662 ARG ARG A . n 
A 1 673 ILE 673 663 663 ILE ILE A . n 
A 1 674 ALA 674 664 664 ALA ALA A . n 
A 1 675 GLU 675 665 665 GLU GLU A . n 
A 1 676 MET 676 666 666 MET MET A . n 
A 1 677 GLY 677 667 667 GLY GLY A . n 
A 1 678 ARG 678 668 668 ARG ARG A . n 
A 1 679 PRO 679 669 669 PRO PRO A . n 
A 1 680 ILE 680 670 670 ILE ILE A . n 
A 1 681 LEU 681 671 671 LEU LEU A . n 
A 1 682 GLY 682 672 672 GLY GLY A . n 
A 1 683 GLU 683 673 673 GLU GLU A . n 
A 1 684 HIS 684 674 674 HIS HIS A . n 
A 1 685 THR 685 675 675 THR THR A . n 
A 1 686 LYS 686 676 676 LYS LYS A . n 
A 1 687 LEU 687 677 677 LEU LEU A . n 
A 1 688 GLU 688 678 678 GLU GLU A . n 
A 1 689 VAL 689 679 679 VAL VAL A . n 
A 1 690 ILE 690 680 680 ILE ILE A . n 
A 1 691 ILE 691 681 681 ILE ILE A . n 
A 1 692 GLU 692 682 682 GLU GLU A . n 
A 1 693 GLU 693 683 683 GLU GLU A . n 
A 1 694 SER 694 684 684 SER SER A . n 
A 1 695 TYR 695 685 685 TYR TYR A . n 
A 1 696 GLU 696 686 686 GLU GLU A . n 
A 1 697 PHE 697 687 687 PHE PHE A . n 
A 1 698 LYS 698 688 688 LYS LYS A . n 
A 1 699 SER 699 689 689 SER SER A . n 
A 1 700 THR 700 690 690 THR THR A . n 
A 1 701 VAL 701 691 691 VAL VAL A . n 
A 1 702 ASP 702 692 692 ASP ASP A . n 
A 1 703 LYS 703 693 693 LYS LYS A . n 
A 1 704 LEU 704 694 694 LEU LEU A . n 
A 1 705 ILE 705 695 695 ILE ILE A . n 
A 1 706 LYS 706 696 696 LYS LYS A . n 
A 1 707 LYS 707 697 697 LYS LYS A . n 
A 1 708 THR 708 698 698 THR THR A . n 
A 1 709 ASN 709 699 ?   ?   ?   A . n 
A 1 710 LEU 710 700 ?   ?   ?   A . n 
A 1 711 ALA 711 701 ?   ?   ?   A . n 
A 1 712 LEU 712 702 ?   ?   ?   A . n 
A 1 713 VAL 713 703 ?   ?   ?   A . n 
A 1 714 VAL 714 704 ?   ?   ?   A . n 
A 1 715 GLY 715 705 ?   ?   ?   A . n 
A 1 716 THR 716 706 ?   ?   ?   A . n 
A 1 717 ASN 717 707 707 ASN ASN A . n 
A 1 718 SER 718 708 708 SER SER A . n 
A 1 719 TRP 719 709 709 TRP TRP A . n 
A 1 720 ARG 720 710 710 ARG ARG A . n 
A 1 721 GLU 721 711 711 GLU GLU A . n 
A 1 722 GLN 722 712 712 GLN GLN A . n 
A 1 723 PHE 723 713 713 PHE PHE A . n 
A 1 724 ILE 724 714 714 ILE ILE A . n 
A 1 725 GLU 725 715 715 GLU GLU A . n 
A 1 726 ALA 726 716 716 ALA ALA A . n 
A 1 727 ILE 727 717 717 ILE ILE A . n 
A 1 728 THR 728 718 718 THR THR A . n 
A 1 729 VAL 729 719 ?   ?   ?   A . n 
A 1 730 SER 730 720 ?   ?   ?   A . n 
A 1 731 ALA 731 721 ?   ?   ?   A . n 
A 1 732 GLY 732 722 ?   ?   ?   A . n 
A 1 733 GLU 733 723 ?   ?   ?   A . n 
A 1 734 ASP 734 724 ?   ?   ?   A . n 
A 1 735 ASP 735 725 ?   ?   ?   A . n 
A 1 736 ASP 736 726 ?   ?   ?   A . n 
A 1 737 ASP 737 727 ?   ?   ?   A . n 
A 1 738 ASP 738 728 ?   ?   ?   A . n 
A 1 739 GLU 739 729 ?   ?   ?   A . n 
A 1 740 CYS 740 730 ?   ?   ?   A . n 
A 1 741 GLY 741 731 ?   ?   ?   A . n 
A 1 742 GLU 742 732 ?   ?   ?   A . n 
A 1 743 GLU 743 733 ?   ?   ?   A . n 
A 1 744 LYS 744 734 ?   ?   ?   A . n 
A 1 745 LEU 745 735 ?   ?   ?   A . n 
A 1 746 PRO 746 736 ?   ?   ?   A . n 
A 1 747 SER 747 737 737 SER SER A . n 
A 1 748 CYS 748 738 738 CYS CYS A . n 
A 1 749 PHE 749 739 739 PHE PHE A . n 
A 1 750 ASP 750 740 740 ASP ASP A . n 
A 1 751 TYR 751 741 741 TYR TYR A . n 
A 1 752 VAL 752 742 742 VAL VAL A . n 
A 1 753 MET 753 743 743 MET MET A . n 
A 1 754 HIS 754 744 744 HIS HIS A . n 
A 1 755 PHE 755 745 745 PHE PHE A . n 
A 1 756 LEU 756 746 746 LEU LEU A . n 
A 1 757 THR 757 747 747 THR THR A . n 
A 1 758 VAL 758 748 748 VAL VAL A . n 
A 1 759 PHE 759 749 749 PHE PHE A . n 
A 1 760 TRP 760 750 750 TRP TRP A . n 
A 1 761 LYS 761 751 751 LYS LYS A . n 
A 1 762 VAL 762 752 752 VAL VAL A . n 
A 1 763 LEU 763 753 753 LEU LEU A . n 
A 1 764 PHE 764 754 754 PHE PHE A . n 
A 1 765 ALA 765 755 755 ALA ALA A . n 
A 1 766 PHE 766 756 756 PHE PHE A . n 
A 1 767 VAL 767 757 757 VAL VAL A . n 
A 1 768 PRO 768 758 758 PRO PRO A . n 
A 1 769 PRO 769 759 759 PRO PRO A . n 
A 1 770 THR 770 760 760 THR THR A . n 
A 1 771 GLU 771 761 761 GLU GLU A . n 
A 1 772 TYR 772 762 762 TYR TYR A . n 
A 1 773 TRP 773 763 763 TRP TRP A . n 
A 1 774 ASN 774 764 764 ASN ASN A . n 
A 1 775 GLY 775 765 765 GLY GLY A . n 
A 1 776 TRP 776 766 766 TRP TRP A . n 
A 1 777 ALA 777 767 767 ALA ALA A . n 
A 1 778 CYS 778 768 768 CYS CYS A . n 
A 1 779 PHE 779 769 769 PHE PHE A . n 
A 1 780 ILE 780 770 770 ILE ILE A . n 
A 1 781 VAL 781 771 771 VAL VAL A . n 
A 1 782 SER 782 772 772 SER SER A . n 
A 1 783 ILE 783 773 773 ILE ILE A . n 
A 1 784 LEU 784 774 774 LEU LEU A . n 
A 1 785 MET 785 775 775 MET MET A . n 
A 1 786 ILE 786 776 776 ILE ILE A . n 
A 1 787 GLY 787 777 777 GLY GLY A . n 
A 1 788 LEU 788 778 778 LEU LEU A . n 
A 1 789 LEU 789 779 779 LEU LEU A . n 
A 1 790 THR 790 780 780 THR THR A . n 
A 1 791 ALA 791 781 781 ALA ALA A . n 
A 1 792 PHE 792 782 782 PHE PHE A . n 
A 1 793 ILE 793 783 783 ILE ILE A . n 
A 1 794 GLY 794 784 784 GLY GLY A . n 
A 1 795 ASP 795 785 785 ASP ASP A . n 
A 1 796 LEU 796 786 786 LEU LEU A . n 
A 1 797 ALA 797 787 787 ALA ALA A . n 
A 1 798 SER 798 788 788 SER SER A . n 
A 1 799 HIS 799 789 789 HIS HIS A . n 
A 1 800 PHE 800 790 790 PHE PHE A . n 
A 1 801 GLY 801 791 791 GLY GLY A . n 
A 1 802 CYS 802 792 792 CYS CYS A . n 
A 1 803 THR 803 793 793 THR THR A . n 
A 1 804 ILE 804 794 794 ILE ILE A . n 
A 1 805 GLY 805 795 795 GLY GLY A . n 
A 1 806 LEU 806 796 796 LEU LEU A . n 
A 1 807 LYS 807 797 797 LYS LYS A . n 
A 1 808 ASP 808 798 798 ASP ASP A . n 
A 1 809 SER 809 799 799 SER SER A . n 
A 1 810 VAL 810 800 800 VAL VAL A . n 
A 1 811 THR 811 801 801 THR THR A . n 
A 1 812 ALA 812 802 802 ALA ALA A . n 
A 1 813 VAL 813 803 803 VAL VAL A . n 
A 1 814 VAL 814 804 804 VAL VAL A . n 
A 1 815 PHE 815 805 805 PHE PHE A . n 
A 1 816 VAL 816 806 806 VAL VAL A . n 
A 1 817 ALA 817 807 807 ALA ALA A . n 
A 1 818 LEU 818 808 808 LEU LEU A . n 
A 1 819 GLY 819 809 809 GLY GLY A . n 
A 1 820 THR 820 810 810 THR THR A . n 
A 1 821 SER 821 811 811 SER SER A . n 
A 1 822 VAL 822 812 812 VAL VAL A . n 
A 1 823 PRO 823 813 813 PRO PRO A . n 
A 1 824 ASP 824 814 814 ASP ASP A . n 
A 1 825 THR 825 815 815 THR THR A . n 
A 1 826 PHE 826 816 816 PHE PHE A . n 
A 1 827 ALA 827 817 817 ALA ALA A . n 
A 1 828 SER 828 818 818 SER SER A . n 
A 1 829 LYS 829 819 819 LYS LYS A . n 
A 1 830 VAL 830 820 820 VAL VAL A . n 
A 1 831 ALA 831 821 821 ALA ALA A . n 
A 1 832 ALA 832 822 822 ALA ALA A . n 
A 1 833 THR 833 823 823 THR THR A . n 
A 1 834 GLN 834 824 824 GLN GLN A . n 
A 1 835 ASP 835 825 825 ASP ASP A . n 
A 1 836 GLN 836 826 826 GLN GLN A . n 
A 1 837 TYR 837 827 827 TYR TYR A . n 
A 1 838 ALA 838 828 828 ALA ALA A . n 
A 1 839 ASP 839 829 829 ASP ASP A . n 
A 1 840 ALA 840 830 830 ALA ALA A . n 
A 1 841 SER 841 831 831 SER SER A . n 
A 1 842 ILE 842 832 832 ILE ILE A . n 
A 1 843 GLY 843 833 833 GLY GLY A . n 
A 1 844 ASN 844 834 834 ASN ASN A . n 
A 1 845 VAL 845 835 835 VAL VAL A . n 
A 1 846 THR 846 836 836 THR THR A . n 
A 1 847 GLY 847 837 837 GLY GLY A . n 
A 1 848 SER 848 838 838 SER SER A . n 
A 1 849 ASN 849 839 839 ASN ASN A . n 
A 1 850 ALA 850 840 840 ALA ALA A . n 
A 1 851 VAL 851 841 841 VAL VAL A . n 
A 1 852 ASN 852 842 842 ASN ASN A . n 
A 1 853 VAL 853 843 843 VAL VAL A . n 
A 1 854 PHE 854 844 844 PHE PHE A . n 
A 1 855 LEU 855 845 845 LEU LEU A . n 
A 1 856 GLY 856 846 846 GLY GLY A . n 
A 1 857 ILE 857 847 847 ILE ILE A . n 
A 1 858 GLY 858 848 848 GLY GLY A . n 
A 1 859 VAL 859 849 849 VAL VAL A . n 
A 1 860 ALA 860 850 850 ALA ALA A . n 
A 1 861 TRP 861 851 851 TRP TRP A . n 
A 1 862 SER 862 852 852 SER SER A . n 
A 1 863 ILE 863 853 853 ILE ILE A . n 
A 1 864 ALA 864 854 854 ALA ALA A . n 
A 1 865 ALA 865 855 855 ALA ALA A . n 
A 1 866 ILE 866 856 856 ILE ILE A . n 
A 1 867 TYR 867 857 857 TYR TYR A . n 
A 1 868 HIS 868 858 858 HIS HIS A . n 
A 1 869 ALA 869 859 859 ALA ALA A . n 
A 1 870 ALA 870 860 860 ALA ALA A . n 
A 1 871 ASN 871 861 861 ASN ASN A . n 
A 1 872 GLY 872 862 862 GLY GLY A . n 
A 1 873 GLU 873 863 863 GLU GLU A . n 
A 1 874 GLN 874 864 864 GLN GLN A . n 
A 1 875 PHE 875 865 865 PHE PHE A . n 
A 1 876 LYS 876 866 866 LYS LYS A . n 
A 1 877 VAL 877 867 867 VAL VAL A . n 
A 1 878 SER 878 868 868 SER SER A . n 
A 1 879 PRO 879 869 869 PRO PRO A . n 
A 1 880 GLY 880 870 870 GLY GLY A . n 
A 1 881 THR 881 871 871 THR THR A . n 
A 1 882 LEU 882 872 872 LEU LEU A . n 
A 1 883 ALA 883 873 873 ALA ALA A . n 
A 1 884 PHE 884 874 874 PHE PHE A . n 
A 1 885 SER 885 875 875 SER SER A . n 
A 1 886 VAL 886 876 876 VAL VAL A . n 
A 1 887 THR 887 877 877 THR THR A . n 
A 1 888 LEU 888 878 878 LEU LEU A . n 
A 1 889 PHE 889 879 879 PHE PHE A . n 
A 1 890 THR 890 880 880 THR THR A . n 
A 1 891 ILE 891 881 881 ILE ILE A . n 
A 1 892 PHE 892 882 882 PHE PHE A . n 
A 1 893 ALA 893 883 883 ALA ALA A . n 
A 1 894 PHE 894 884 884 PHE PHE A . n 
A 1 895 ILE 895 885 885 ILE ILE A . n 
A 1 896 ASN 896 886 886 ASN ASN A . n 
A 1 897 VAL 897 887 887 VAL VAL A . n 
A 1 898 GLY 898 888 888 GLY GLY A . n 
A 1 899 VAL 899 889 889 VAL VAL A . n 
A 1 900 LEU 900 890 890 LEU LEU A . n 
A 1 901 LEU 901 891 891 LEU LEU A . n 
A 1 902 TYR 902 892 892 TYR TYR A . n 
A 1 903 ARG 903 893 893 ARG ARG A . n 
A 1 904 ARG 904 894 894 ARG ARG A . n 
A 1 905 ARG 905 895 895 ARG ARG A . n 
A 1 906 PRO 906 896 896 PRO PRO A . n 
A 1 907 GLU 907 897 897 GLU GLU A . n 
A 1 908 ILE 908 898 898 ILE ILE A . n 
A 1 909 GLY 909 899 899 GLY GLY A . n 
A 1 910 GLY 910 900 900 GLY GLY A . n 
A 1 911 GLU 911 901 901 GLU GLU A . n 
A 1 912 LEU 912 902 902 LEU LEU A . n 
A 1 913 GLY 913 903 903 GLY GLY A . n 
A 1 914 GLY 914 904 904 GLY GLY A . n 
A 1 915 PRO 915 905 905 PRO PRO A . n 
A 1 916 ARG 916 906 906 ARG ARG A . n 
A 1 917 THR 917 907 907 THR THR A . n 
A 1 918 ALA 918 908 908 ALA ALA A . n 
A 1 919 LYS 919 909 909 LYS LYS A . n 
A 1 920 LEU 920 910 910 LEU LEU A . n 
A 1 921 LEU 921 911 911 LEU LEU A . n 
A 1 922 THR 922 912 912 THR THR A . n 
A 1 923 SER 923 913 913 SER SER A . n 
A 1 924 CYS 924 914 914 CYS CYS A . n 
A 1 925 LEU 925 915 915 LEU LEU A . n 
A 1 926 PHE 926 916 916 PHE PHE A . n 
A 1 927 VAL 927 917 917 VAL VAL A . n 
A 1 928 LEU 928 918 918 LEU LEU A . n 
A 1 929 LEU 929 919 919 LEU LEU A . n 
A 1 930 TRP 930 920 920 TRP TRP A . n 
A 1 931 LEU 931 921 921 LEU LEU A . n 
A 1 932 LEU 932 922 922 LEU LEU A . n 
A 1 933 TYR 933 923 923 TYR TYR A . n 
A 1 934 ILE 934 924 924 ILE ILE A . n 
A 1 935 PHE 935 925 925 PHE PHE A . n 
A 1 936 PHE 936 926 926 PHE PHE A . n 
A 1 937 SER 937 927 927 SER SER A . n 
A 1 938 SER 938 928 928 SER SER A . n 
A 1 939 LEU 939 929 929 LEU LEU A . n 
A 1 940 GLU 940 930 930 GLU GLU A . n 
A 1 941 ALA 941 931 931 ALA ALA A . n 
A 1 942 TYR 942 932 932 TYR TYR A . n 
A 1 943 CYS 943 933 933 CYS CYS A . n 
A 1 944 HIS 944 934 934 HIS HIS A . n 
A 1 945 ILE 945 935 935 ILE ALA A . n 
A 1 946 LYS 946 936 ?   ?   ?   A . n 
A 1 947 GLY 947 937 ?   ?   ?   A . n 
A 1 948 PHE 948 938 ?   ?   ?   A . n 
A 1 949 ALA 949 939 ?   ?   ?   A . n 
A 1 950 ALA 950 940 ?   ?   ?   A . n 
A 1 951 ALA 951 941 ?   ?   ?   A . n 
A 1 952 GLY 952 942 ?   ?   ?   A . n 
A 1 953 GLY 953 943 ?   ?   ?   A . n 
A 1 954 SER 954 944 ?   ?   ?   A . n 
A 1 955 TRP 955 945 ?   ?   ?   A . n 
A 1 956 SER 956 946 ?   ?   ?   A . n 
A 1 957 HIS 957 947 ?   ?   ?   A . n 
A 1 958 PRO 958 948 ?   ?   ?   A . n 
A 1 959 GLN 959 949 ?   ?   ?   A . n 
A 1 960 PHE 960 950 ?   ?   ?   A . n 
A 1 961 GLU 961 951 ?   ?   ?   A . n 
A 1 962 LYS 962 952 ?   ?   ?   A . n 
A 1 963 GLY 963 953 ?   ?   ?   A . n 
A 1 964 GLY 964 954 ?   ?   ?   A . n 
A 1 965 GLY 965 955 ?   ?   ?   A . n 
A 1 966 SER 966 956 ?   ?   ?   A . n 
A 1 967 GLY 967 957 ?   ?   ?   A . n 
A 1 968 GLY 968 958 ?   ?   ?   A . n 
A 1 969 GLY 969 959 ?   ?   ?   A . n 
A 1 970 SER 970 960 ?   ?   ?   A . n 
A 1 971 GLY 971 961 ?   ?   ?   A . n 
A 1 972 GLY 972 962 ?   ?   ?   A . n 
A 1 973 SER 973 963 ?   ?   ?   A . n 
A 1 974 ALA 974 964 ?   ?   ?   A . n 
A 1 975 TRP 975 965 ?   ?   ?   A . n 
A 1 976 SER 976 966 ?   ?   ?   A . n 
A 1 977 HIS 977 967 ?   ?   ?   A . n 
A 1 978 PRO 978 968 ?   ?   ?   A . n 
A 1 979 GLN 979 969 ?   ?   ?   A . n 
A 1 980 PHE 980 970 ?   ?   ?   A . n 
A 1 981 GLU 981 971 ?   ?   ?   A . n 
A 1 982 LYS 982 972 ?   ?   ?   A . n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 CA  ? ? CA  ? ? 'SUBJECT OF INVESTIGATION' ? 
2 PIO ? ? PIO ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 CA  1 1001 1001 CA  CA  A . 
C 3 PIO 1 1002 1101 PIO PIO A . 
D 2 CA  1 1003 1001 CA  CA  A . 
E 2 CA  1 1004 1002 CA  CA  A . 
F 2 CA  1 1005 1003 CA  CA  A . 
G 2 CA  1 1006 1004 CA  CA  A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A ILE 935 ? CG1 ? A ILE 945 CG1 
2 1 Y 1 A ILE 935 ? CG2 ? A ILE 945 CG2 
3 1 Y 1 A ILE 935 ? CD1 ? A ILE 945 CD1 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9IV8 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               ? 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9IV8 
_refine.pdbx_refine_id                           'ELECTRON MICROSCOPY' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            3.50 
_refine.ls_d_res_low                             ? 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     ? 
_refine.ls_number_reflns_R_free                  ? 
_refine.ls_number_reflns_R_work                  ? 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    ? 
_refine.ls_percent_reflns_R_free                 ? 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          ? 
_refine.ls_R_factor_R_free                       ? 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       ? 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    ? 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.correlation_coeff_I_to_Fcsqd_work        ? 
_refine.correlation_coeff_I_to_Fcsqd_free        ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               ? 
_refine.pdbx_method_to_determine_struct          ? 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'REAL-SPACE (WEIGHTED MAP SUM AT ATOM CENTERS)' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             ? 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             ? 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           ? 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            ? 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'ELECTRON MICROSCOPY' ? 0.004 ? 6077 ? f_bond_d           ? ? 
'ELECTRON MICROSCOPY' ? 0.683 ? 8246 ? f_angle_d          ? ? 
'ELECTRON MICROSCOPY' ? 5.116 ? 829  ? f_dihedral_angle_d ? ? 
'ELECTRON MICROSCOPY' ? 0.049 ? 953  ? f_chiral_restr     ? ? 
'ELECTRON MICROSCOPY' ? 0.005 ? 1026 ? f_plane_restr      ? ? 
# 
_struct.entry_id                     9IV8 
_struct.title                        'Cryo-EM structure of human NCX1 in PIP2 diC8 bound state' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9IV8 
_struct_keywords.text            'sodium calcium exchanger, Na/Ca exchanger, TRANSPORT PROTEIN' 
_struct_keywords.pdbx_keywords   'TRANSPORT PROTEIN' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 2 ? 
E N N 2 ? 
F N N 2 ? 
G N N 2 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    NAC1_HUMAN 
_struct_ref.pdbx_db_accession          P32418 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATV
YFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHN
FTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFF
FFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLEVDERDQDDE
EARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEV
TENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGII
DDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKV
LRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKAL
LLNELGGFTITGKYLFGQPVFRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESY
EFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNG
WACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFL
GIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIF
FSSLEAYCHIKGF
;
_struct_ref.pdbx_align_begin           1 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              9IV8 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 1 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 948 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             P32418 
_struct_ref_seq.db_align_beg                  1 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  973 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       -34 
_struct_ref_seq.pdbx_auth_seq_align_end       938 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9IV8 ?   A ?   ? UNP P32418 GLY 376 deletion         ?   1  
1 9IV8 ?   A ?   ? UNP P32418 ASN 377 deletion         ?   2  
1 9IV8 ?   A ?   ? UNP P32418 ILE 378 deletion         ?   3  
1 9IV8 ?   A ?   ? UNP P32418 LEU 379 deletion         ?   4  
1 9IV8 ?   A ?   ? UNP P32418 LYS 380 deletion         ?   5  
1 9IV8 ?   A ?   ? UNP P32418 ARG 381 deletion         ?   6  
1 9IV8 ?   A ?   ? UNP P32418 HIS 382 deletion         ?   7  
1 9IV8 ?   A ?   ? UNP P32418 ALA 383 deletion         ?   8  
1 9IV8 ?   A ?   ? UNP P32418 ALA 384 deletion         ?   9  
1 9IV8 ?   A ?   ? UNP P32418 ASP 385 deletion         ?   10 
1 9IV8 ?   A ?   ? UNP P32418 GLN 386 deletion         ?   11 
1 9IV8 ?   A ?   ? UNP P32418 ALA 387 deletion         ?   12 
1 9IV8 ?   A ?   ? UNP P32418 ARG 388 deletion         ?   13 
1 9IV8 ?   A ?   ? UNP P32418 LYS 389 deletion         ?   14 
1 9IV8 ?   A ?   ? UNP P32418 ALA 390 deletion         ?   15 
1 9IV8 ?   A ?   ? UNP P32418 VAL 391 deletion         ?   16 
1 9IV8 ?   A ?   ? UNP P32418 SER 392 deletion         ?   17 
1 9IV8 ?   A ?   ? UNP P32418 MET 393 deletion         ?   18 
1 9IV8 ?   A ?   ? UNP P32418 HIS 394 deletion         ?   19 
1 9IV8 ?   A ?   ? UNP P32418 GLU 395 deletion         ?   20 
1 9IV8 ?   A ?   ? UNP P32418 VAL 396 deletion         ?   21 
1 9IV8 ?   A ?   ? UNP P32418 ASN 397 deletion         ?   22 
1 9IV8 ?   A ?   ? UNP P32418 THR 398 deletion         ?   23 
1 9IV8 ?   A ?   ? UNP P32418 GLU 399 deletion         ?   24 
1 9IV8 ?   A ?   ? UNP P32418 VAL 400 deletion         ?   25 
1 9IV8 ALA A 949 ? UNP P32418 ?   ?   'expression tag' 939 26 
1 9IV8 ALA A 950 ? UNP P32418 ?   ?   'expression tag' 940 27 
1 9IV8 ALA A 951 ? UNP P32418 ?   ?   'expression tag' 941 28 
1 9IV8 GLY A 952 ? UNP P32418 ?   ?   'expression tag' 942 29 
1 9IV8 GLY A 953 ? UNP P32418 ?   ?   'expression tag' 943 30 
1 9IV8 SER A 954 ? UNP P32418 ?   ?   'expression tag' 944 31 
1 9IV8 TRP A 955 ? UNP P32418 ?   ?   'expression tag' 945 32 
1 9IV8 SER A 956 ? UNP P32418 ?   ?   'expression tag' 946 33 
1 9IV8 HIS A 957 ? UNP P32418 ?   ?   'expression tag' 947 34 
1 9IV8 PRO A 958 ? UNP P32418 ?   ?   'expression tag' 948 35 
1 9IV8 GLN A 959 ? UNP P32418 ?   ?   'expression tag' 949 36 
1 9IV8 PHE A 960 ? UNP P32418 ?   ?   'expression tag' 950 37 
1 9IV8 GLU A 961 ? UNP P32418 ?   ?   'expression tag' 951 38 
1 9IV8 LYS A 962 ? UNP P32418 ?   ?   'expression tag' 952 39 
1 9IV8 GLY A 963 ? UNP P32418 ?   ?   'expression tag' 953 40 
1 9IV8 GLY A 964 ? UNP P32418 ?   ?   'expression tag' 954 41 
1 9IV8 GLY A 965 ? UNP P32418 ?   ?   'expression tag' 955 42 
1 9IV8 SER A 966 ? UNP P32418 ?   ?   'expression tag' 956 43 
1 9IV8 GLY A 967 ? UNP P32418 ?   ?   'expression tag' 957 44 
1 9IV8 GLY A 968 ? UNP P32418 ?   ?   'expression tag' 958 45 
1 9IV8 GLY A 969 ? UNP P32418 ?   ?   'expression tag' 959 46 
1 9IV8 SER A 970 ? UNP P32418 ?   ?   'expression tag' 960 47 
1 9IV8 GLY A 971 ? UNP P32418 ?   ?   'expression tag' 961 48 
1 9IV8 GLY A 972 ? UNP P32418 ?   ?   'expression tag' 962 49 
1 9IV8 SER A 973 ? UNP P32418 ?   ?   'expression tag' 963 50 
1 9IV8 ALA A 974 ? UNP P32418 ?   ?   'expression tag' 964 51 
1 9IV8 TRP A 975 ? UNP P32418 ?   ?   'expression tag' 965 52 
1 9IV8 SER A 976 ? UNP P32418 ?   ?   'expression tag' 966 53 
1 9IV8 HIS A 977 ? UNP P32418 ?   ?   'expression tag' 967 54 
1 9IV8 PRO A 978 ? UNP P32418 ?   ?   'expression tag' 968 55 
1 9IV8 GLN A 979 ? UNP P32418 ?   ?   'expression tag' 969 56 
1 9IV8 PHE A 980 ? UNP P32418 ?   ?   'expression tag' 970 57 
1 9IV8 GLU A 981 ? UNP P32418 ?   ?   'expression tag' 971 58 
1 9IV8 LYS A 982 ? UNP P32418 ?   ?   'expression tag' 972 59 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   ? 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLY A 72  ? THR A 107 ? GLY A 37  THR A 72  1 ? 36 
HELX_P HELX_P2  AA2 THR A 133 ? SER A 145 ? THR A 98  SER A 110 1 ? 13 
HELX_P HELX_P3  AA3 SER A 145 ? HIS A 159 ? SER A 110 HIS A 124 1 ? 15 
HELX_P HELX_P4  AA4 ASP A 165 ? VAL A 190 ? ASP A 130 VAL A 155 1 ? 26 
HELX_P HELX_P5  AA5 HIS A 200 ? SER A 223 ? HIS A 165 SER A 188 1 ? 24 
HELX_P HELX_P6  AA6 GLU A 231 ? LYS A 260 ? GLU A 196 LYS A 225 1 ? 30 
HELX_P HELX_P7  AA7 SER A 610 ? ASN A 618 ? SER A 600 ASN A 608 1 ? 9  
HELX_P HELX_P8  AA8 LYS A 666 ? MET A 676 ? LYS A 656 MET A 666 1 ? 11 
HELX_P HELX_P9  AA9 SER A 694 ? THR A 708 ? SER A 684 THR A 698 1 ? 15 
HELX_P HELX_P10 AB1 SER A 718 ? ILE A 727 ? SER A 708 ILE A 717 1 ? 10 
HELX_P HELX_P11 AB2 CYS A 748 ? ALA A 765 ? CYS A 738 ALA A 755 1 ? 18 
HELX_P HELX_P12 AB3 GLU A 771 ? ASN A 774 ? GLU A 761 ASN A 764 5 ? 4  
HELX_P HELX_P13 AB4 GLY A 775 ? GLY A 805 ? GLY A 765 GLY A 795 1 ? 31 
HELX_P HELX_P14 AB5 LYS A 807 ? VAL A 814 ? LYS A 797 VAL A 804 1 ? 8  
HELX_P HELX_P15 AB6 PHE A 815 ? SER A 821 ? PHE A 805 SER A 811 1 ? 7  
HELX_P HELX_P16 AB7 SER A 821 ? ASP A 835 ? SER A 811 ASP A 825 1 ? 15 
HELX_P HELX_P17 AB8 ALA A 838 ? GLY A 872 ? ALA A 828 GLY A 862 1 ? 35 
HELX_P HELX_P18 AB9 PRO A 879 ? ARG A 903 ? PRO A 869 ARG A 893 1 ? 25 
HELX_P HELX_P19 AC1 PRO A 915 ? TYR A 942 ? PRO A 905 TYR A 932 1 ? 28 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1  disulf ? ? A CYS 55  SG  ? ? ? 1_555 A CYS 802 SG ? ? A CYS 20  A CYS 792  1_555 ? ? ? ? ? ? ? 2.030 ? ? 
metalc1  metalc ? ? A ILE 221 O   ? ? ? 1_555 B CA  .   CA ? ? A ILE 186 A CA  1001 1_555 ? ? ? ? ? ? ? 2.971 ? ? 
metalc2  metalc ? ? A ILE 225 O   ? ? ? 1_555 B CA  .   CA ? ? A ILE 190 A CA  1001 1_555 ? ? ? ? ? ? ? 2.451 ? ? 
metalc3  metalc ? ? A SER 226 O   ? ? ? 1_555 B CA  .   CA ? ? A SER 191 A CA  1001 1_555 ? ? ? ? ? ? ? 2.354 ? ? 
metalc4  metalc ? ? A VAL 229 O   ? ? ? 1_555 B CA  .   CA ? ? A VAL 194 A CA  1001 1_555 ? ? ? ? ? ? ? 3.027 ? ? 
metalc5  metalc ? ? A GLU 234 OE1 ? ? ? 1_555 B CA  .   CA ? ? A GLU 199 A CA  1001 1_555 ? ? ? ? ? ? ? 2.336 ? ? 
metalc6  metalc ? ? A GLU 234 OE2 ? ? ? 1_555 B CA  .   CA ? ? A GLU 199 A CA  1001 1_555 ? ? ? ? ? ? ? 2.624 ? ? 
metalc7  metalc ? ? A GLU 395 OE2 ? ? ? 1_555 E CA  .   CA ? ? A GLU 385 A CA  1004 1_555 ? ? ? ? ? ? ? 2.266 ? ? 
metalc8  metalc ? ? A GLU 395 OE1 ? ? ? 1_555 F CA  .   CA ? ? A GLU 385 A CA  1005 1_555 ? ? ? ? ? ? ? 2.377 ? ? 
metalc9  metalc ? ? A GLU 395 OE1 ? ? ? 1_555 G CA  .   CA ? ? A GLU 385 A CA  1006 1_555 ? ? ? ? ? ? ? 2.391 ? ? 
metalc10 metalc ? ? A GLU 395 OE2 ? ? ? 1_555 G CA  .   CA ? ? A GLU 385 A CA  1006 1_555 ? ? ? ? ? ? ? 2.318 ? ? 
metalc11 metalc ? ? A ASP 431 OD2 ? ? ? 1_555 D CA  .   CA ? ? A ASP 421 A CA  1003 1_555 ? ? ? ? ? ? ? 2.739 ? ? 
metalc12 metalc ? ? A ASP 431 OD1 ? ? ? 1_555 E CA  .   CA ? ? A ASP 421 A CA  1004 1_555 ? ? ? ? ? ? ? 2.480 ? ? 
metalc13 metalc ? ? A ASP 431 OD2 ? ? ? 1_555 E CA  .   CA ? ? A ASP 421 A CA  1004 1_555 ? ? ? ? ? ? ? 2.282 ? ? 
metalc14 metalc ? ? A ASP 456 OD1 ? ? ? 1_555 F CA  .   CA ? ? A ASP 446 A CA  1005 1_555 ? ? ? ? ? ? ? 2.460 ? ? 
metalc15 metalc ? ? A ASP 457 OD1 ? ? ? 1_555 G CA  .   CA ? ? A ASP 447 A CA  1006 1_555 ? ? ? ? ? ? ? 2.748 ? ? 
metalc16 metalc ? ? A ILE 459 O   ? ? ? 1_555 G CA  .   CA ? ? A ILE 449 A CA  1006 1_555 ? ? ? ? ? ? ? 2.658 ? ? 
metalc17 metalc ? ? A GLU 461 OE1 ? ? ? 1_555 D CA  .   CA ? ? A GLU 451 A CA  1003 1_555 ? ? ? ? ? ? ? 2.381 ? ? 
metalc18 metalc ? ? A GLU 461 OE1 ? ? ? 1_555 E CA  .   CA ? ? A GLU 451 A CA  1004 1_555 ? ? ? ? ? ? ? 3.070 ? ? 
metalc19 metalc ? ? A GLU 461 OE2 ? ? ? 1_555 E CA  .   CA ? ? A GLU 451 A CA  1004 1_555 ? ? ? ? ? ? ? 2.358 ? ? 
metalc20 metalc ? ? A GLU 461 OE2 ? ? ? 1_555 G CA  .   CA ? ? A GLU 451 A CA  1006 1_555 ? ? ? ? ? ? ? 2.968 ? ? 
metalc21 metalc ? ? A GLU 464 OE1 ? ? ? 1_555 D CA  .   CA ? ? A GLU 454 A CA  1003 1_555 ? ? ? ? ? ? ? 2.840 ? ? 
metalc22 metalc ? ? A GLU 464 OE2 ? ? ? 1_555 D CA  .   CA ? ? A GLU 454 A CA  1003 1_555 ? ? ? ? ? ? ? 2.946 ? ? 
metalc23 metalc ? ? A ASP 508 OD2 ? ? ? 1_555 G CA  .   CA ? ? A ASP 498 A CA  1006 1_555 ? ? ? ? ? ? ? 2.336 ? ? 
metalc24 metalc ? ? A ASP 510 OD1 ? ? ? 1_555 F CA  .   CA ? ? A ASP 500 A CA  1005 1_555 ? ? ? ? ? ? ? 2.379 ? ? 
metalc25 metalc ? ? A ASP 510 OD2 ? ? ? 1_555 F CA  .   CA ? ? A ASP 500 A CA  1005 1_555 ? ? ? ? ? ? ? 3.005 ? ? 
metalc26 metalc ? ? A ASP 510 OD2 ? ? ? 1_555 G CA  .   CA ? ? A ASP 500 A CA  1006 1_555 ? ? ? ? ? ? ? 2.410 ? ? 
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
metalc ? ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  O   ? A ILE 221 ? A ILE 186 ? 1_555 CA ? B CA . ? A CA 1001 ? 1_555 O   ? A ILE 225 ? A ILE 190 ? 1_555 70.3  ? 
2  O   ? A ILE 221 ? A ILE 186 ? 1_555 CA ? B CA . ? A CA 1001 ? 1_555 O   ? A SER 226 ? A SER 191 ? 1_555 90.1  ? 
3  O   ? A ILE 225 ? A ILE 190 ? 1_555 CA ? B CA . ? A CA 1001 ? 1_555 O   ? A SER 226 ? A SER 191 ? 1_555 76.7  ? 
4  O   ? A ILE 221 ? A ILE 186 ? 1_555 CA ? B CA . ? A CA 1001 ? 1_555 O   ? A VAL 229 ? A VAL 194 ? 1_555 75.7  ? 
5  O   ? A ILE 225 ? A ILE 190 ? 1_555 CA ? B CA . ? A CA 1001 ? 1_555 O   ? A VAL 229 ? A VAL 194 ? 1_555 136.2 ? 
6  O   ? A SER 226 ? A SER 191 ? 1_555 CA ? B CA . ? A CA 1001 ? 1_555 O   ? A VAL 229 ? A VAL 194 ? 1_555 76.5  ? 
7  O   ? A ILE 221 ? A ILE 186 ? 1_555 CA ? B CA . ? A CA 1001 ? 1_555 OE1 ? A GLU 234 ? A GLU 199 ? 1_555 74.1  ? 
8  O   ? A ILE 225 ? A ILE 190 ? 1_555 CA ? B CA . ? A CA 1001 ? 1_555 OE1 ? A GLU 234 ? A GLU 199 ? 1_555 111.4 ? 
9  O   ? A SER 226 ? A SER 191 ? 1_555 CA ? B CA . ? A CA 1001 ? 1_555 OE1 ? A GLU 234 ? A GLU 199 ? 1_555 157.5 ? 
10 O   ? A VAL 229 ? A VAL 194 ? 1_555 CA ? B CA . ? A CA 1001 ? 1_555 OE1 ? A GLU 234 ? A GLU 199 ? 1_555 84.0  ? 
11 O   ? A ILE 221 ? A ILE 186 ? 1_555 CA ? B CA . ? A CA 1001 ? 1_555 OE2 ? A GLU 234 ? A GLU 199 ? 1_555 126.1 ? 
12 O   ? A ILE 225 ? A ILE 190 ? 1_555 CA ? B CA . ? A CA 1001 ? 1_555 OE2 ? A GLU 234 ? A GLU 199 ? 1_555 123.8 ? 
13 O   ? A SER 226 ? A SER 191 ? 1_555 CA ? B CA . ? A CA 1001 ? 1_555 OE2 ? A GLU 234 ? A GLU 199 ? 1_555 141.6 ? 
14 O   ? A VAL 229 ? A VAL 194 ? 1_555 CA ? B CA . ? A CA 1001 ? 1_555 OE2 ? A GLU 234 ? A GLU 199 ? 1_555 98.4  ? 
15 OE1 ? A GLU 234 ? A GLU 199 ? 1_555 CA ? B CA . ? A CA 1001 ? 1_555 OE2 ? A GLU 234 ? A GLU 199 ? 1_555 52.0  ? 
16 OE2 ? A GLU 395 ? A GLU 385 ? 1_555 CA ? E CA . ? A CA 1004 ? 1_555 OD1 ? A ASP 431 ? A ASP 421 ? 1_555 114.1 ? 
17 OE2 ? A GLU 395 ? A GLU 385 ? 1_555 CA ? E CA . ? A CA 1004 ? 1_555 OD2 ? A ASP 431 ? A ASP 421 ? 1_555 166.5 ? 
18 OD1 ? A ASP 431 ? A ASP 421 ? 1_555 CA ? E CA . ? A CA 1004 ? 1_555 OD2 ? A ASP 431 ? A ASP 421 ? 1_555 54.6  ? 
19 OE2 ? A GLU 395 ? A GLU 385 ? 1_555 CA ? E CA . ? A CA 1004 ? 1_555 OE1 ? A GLU 461 ? A GLU 451 ? 1_555 129.4 ? 
20 OD1 ? A ASP 431 ? A ASP 421 ? 1_555 CA ? E CA . ? A CA 1004 ? 1_555 OE1 ? A GLU 461 ? A GLU 451 ? 1_555 116.0 ? 
21 OD2 ? A ASP 431 ? A ASP 421 ? 1_555 CA ? E CA . ? A CA 1004 ? 1_555 OE1 ? A GLU 461 ? A GLU 451 ? 1_555 61.4  ? 
22 OE2 ? A GLU 395 ? A GLU 385 ? 1_555 CA ? E CA . ? A CA 1004 ? 1_555 OE2 ? A GLU 461 ? A GLU 451 ? 1_555 90.2  ? 
23 OD1 ? A ASP 431 ? A ASP 421 ? 1_555 CA ? E CA . ? A CA 1004 ? 1_555 OE2 ? A GLU 461 ? A GLU 451 ? 1_555 150.7 ? 
24 OD2 ? A ASP 431 ? A ASP 421 ? 1_555 CA ? E CA . ? A CA 1004 ? 1_555 OE2 ? A GLU 461 ? A GLU 451 ? 1_555 102.8 ? 
25 OE1 ? A GLU 461 ? A GLU 451 ? 1_555 CA ? E CA . ? A CA 1004 ? 1_555 OE2 ? A GLU 461 ? A GLU 451 ? 1_555 45.4  ? 
26 OE1 ? A GLU 395 ? A GLU 385 ? 1_555 CA ? F CA . ? A CA 1005 ? 1_555 OD1 ? A ASP 456 ? A ASP 446 ? 1_555 85.2  ? 
27 OE1 ? A GLU 395 ? A GLU 385 ? 1_555 CA ? F CA . ? A CA 1005 ? 1_555 OD1 ? A ASP 510 ? A ASP 500 ? 1_555 104.5 ? 
28 OD1 ? A ASP 456 ? A ASP 446 ? 1_555 CA ? F CA . ? A CA 1005 ? 1_555 OD1 ? A ASP 510 ? A ASP 500 ? 1_555 142.0 ? 
29 OE1 ? A GLU 395 ? A GLU 385 ? 1_555 CA ? F CA . ? A CA 1005 ? 1_555 OD2 ? A ASP 510 ? A ASP 500 ? 1_555 63.4  ? 
30 OD1 ? A ASP 456 ? A ASP 446 ? 1_555 CA ? F CA . ? A CA 1005 ? 1_555 OD2 ? A ASP 510 ? A ASP 500 ? 1_555 114.8 ? 
31 OD1 ? A ASP 510 ? A ASP 500 ? 1_555 CA ? F CA . ? A CA 1005 ? 1_555 OD2 ? A ASP 510 ? A ASP 500 ? 1_555 46.3  ? 
32 OE1 ? A GLU 395 ? A GLU 385 ? 1_555 CA ? G CA . ? A CA 1006 ? 1_555 OE2 ? A GLU 395 ? A GLU 385 ? 1_555 55.5  ? 
33 OE1 ? A GLU 395 ? A GLU 385 ? 1_555 CA ? G CA . ? A CA 1006 ? 1_555 OD1 ? A ASP 457 ? A ASP 447 ? 1_555 108.2 ? 
34 OE2 ? A GLU 395 ? A GLU 385 ? 1_555 CA ? G CA . ? A CA 1006 ? 1_555 OD1 ? A ASP 457 ? A ASP 447 ? 1_555 90.9  ? 
35 OE1 ? A GLU 395 ? A GLU 385 ? 1_555 CA ? G CA . ? A CA 1006 ? 1_555 O   ? A ILE 459 ? A ILE 449 ? 1_555 142.3 ? 
36 OE2 ? A GLU 395 ? A GLU 385 ? 1_555 CA ? G CA . ? A CA 1006 ? 1_555 O   ? A ILE 459 ? A ILE 449 ? 1_555 156.9 ? 
37 OD1 ? A ASP 457 ? A ASP 447 ? 1_555 CA ? G CA . ? A CA 1006 ? 1_555 O   ? A ILE 459 ? A ILE 449 ? 1_555 93.7  ? 
38 OE1 ? A GLU 395 ? A GLU 385 ? 1_555 CA ? G CA . ? A CA 1006 ? 1_555 OE2 ? A GLU 461 ? A GLU 451 ? 1_555 130.9 ? 
39 OE2 ? A GLU 395 ? A GLU 385 ? 1_555 CA ? G CA . ? A CA 1006 ? 1_555 OE2 ? A GLU 461 ? A GLU 451 ? 1_555 75.5  ? 
40 OD1 ? A ASP 457 ? A ASP 447 ? 1_555 CA ? G CA . ? A CA 1006 ? 1_555 OE2 ? A GLU 461 ? A GLU 451 ? 1_555 71.7  ? 
41 O   ? A ILE 459 ? A ILE 449 ? 1_555 CA ? G CA . ? A CA 1006 ? 1_555 OE2 ? A GLU 461 ? A GLU 451 ? 1_555 84.4  ? 
42 OE1 ? A GLU 395 ? A GLU 385 ? 1_555 CA ? G CA . ? A CA 1006 ? 1_555 OD2 ? A ASP 508 ? A ASP 498 ? 1_555 104.4 ? 
43 OE2 ? A GLU 395 ? A GLU 385 ? 1_555 CA ? G CA . ? A CA 1006 ? 1_555 OD2 ? A ASP 508 ? A ASP 498 ? 1_555 92.6  ? 
44 OD1 ? A ASP 457 ? A ASP 447 ? 1_555 CA ? G CA . ? A CA 1006 ? 1_555 OD2 ? A ASP 508 ? A ASP 498 ? 1_555 142.5 ? 
45 O   ? A ILE 459 ? A ILE 449 ? 1_555 CA ? G CA . ? A CA 1006 ? 1_555 OD2 ? A ASP 508 ? A ASP 498 ? 1_555 70.2  ? 
46 OE2 ? A GLU 461 ? A GLU 451 ? 1_555 CA ? G CA . ? A CA 1006 ? 1_555 OD2 ? A ASP 508 ? A ASP 498 ? 1_555 73.0  ? 
47 OE1 ? A GLU 395 ? A GLU 385 ? 1_555 CA ? G CA . ? A CA 1006 ? 1_555 OD2 ? A ASP 510 ? A ASP 500 ? 1_555 73.7  ? 
48 OE2 ? A GLU 395 ? A GLU 385 ? 1_555 CA ? G CA . ? A CA 1006 ? 1_555 OD2 ? A ASP 510 ? A ASP 500 ? 1_555 128.8 ? 
49 OD1 ? A ASP 457 ? A ASP 447 ? 1_555 CA ? G CA . ? A CA 1006 ? 1_555 OD2 ? A ASP 510 ? A ASP 500 ? 1_555 112.6 ? 
50 O   ? A ILE 459 ? A ILE 449 ? 1_555 CA ? G CA . ? A CA 1006 ? 1_555 OD2 ? A ASP 510 ? A ASP 500 ? 1_555 69.7  ? 
51 OE2 ? A GLU 461 ? A GLU 451 ? 1_555 CA ? G CA . ? A CA 1006 ? 1_555 OD2 ? A ASP 510 ? A ASP 500 ? 1_555 153.8 ? 
52 OD2 ? A ASP 508 ? A ASP 498 ? 1_555 CA ? G CA . ? A CA 1006 ? 1_555 OD2 ? A ASP 510 ? A ASP 500 ? 1_555 93.9  ? 
53 OD2 ? A ASP 431 ? A ASP 421 ? 1_555 CA ? D CA . ? A CA 1003 ? 1_555 OE1 ? A GLU 461 ? A GLU 451 ? 1_555 66.2  ? 
54 OD2 ? A ASP 431 ? A ASP 421 ? 1_555 CA ? D CA . ? A CA 1003 ? 1_555 OE1 ? A GLU 464 ? A GLU 454 ? 1_555 61.2  ? 
55 OE1 ? A GLU 461 ? A GLU 451 ? 1_555 CA ? D CA . ? A CA 1003 ? 1_555 OE1 ? A GLU 464 ? A GLU 454 ? 1_555 83.3  ? 
56 OD2 ? A ASP 431 ? A ASP 421 ? 1_555 CA ? D CA . ? A CA 1003 ? 1_555 OE2 ? A GLU 464 ? A GLU 454 ? 1_555 96.5  ? 
57 OE1 ? A GLU 461 ? A GLU 451 ? 1_555 CA ? D CA . ? A CA 1003 ? 1_555 OE2 ? A GLU 464 ? A GLU 454 ? 1_555 72.4  ? 
58 OE1 ? A GLU 464 ? A GLU 454 ? 1_555 CA ? D CA . ? A CA 1003 ? 1_555 OE2 ? A GLU 464 ? A GLU 454 ? 1_555 44.4  ? 
# 
_pdbx_modification_feature.ordinal                            1 
_pdbx_modification_feature.label_comp_id                      CYS 
_pdbx_modification_feature.label_asym_id                      A 
_pdbx_modification_feature.label_seq_id                       55 
_pdbx_modification_feature.label_alt_id                       ? 
_pdbx_modification_feature.modified_residue_label_comp_id     CYS 
_pdbx_modification_feature.modified_residue_label_asym_id     A 
_pdbx_modification_feature.modified_residue_label_seq_id      802 
_pdbx_modification_feature.modified_residue_label_alt_id      ? 
_pdbx_modification_feature.auth_comp_id                       CYS 
_pdbx_modification_feature.auth_asym_id                       A 
_pdbx_modification_feature.auth_seq_id                        20 
_pdbx_modification_feature.PDB_ins_code                       ? 
_pdbx_modification_feature.symmetry                           1_555 
_pdbx_modification_feature.modified_residue_auth_comp_id      CYS 
_pdbx_modification_feature.modified_residue_auth_asym_id      A 
_pdbx_modification_feature.modified_residue_auth_seq_id       792 
_pdbx_modification_feature.modified_residue_PDB_ins_code      ? 
_pdbx_modification_feature.modified_residue_symmetry          1_555 
_pdbx_modification_feature.comp_id_linking_atom               SG 
_pdbx_modification_feature.modified_residue_id_linking_atom   SG 
_pdbx_modification_feature.modified_residue_id                . 
_pdbx_modification_feature.ref_pcm_id                         . 
_pdbx_modification_feature.ref_comp_id                        . 
_pdbx_modification_feature.type                               None 
_pdbx_modification_feature.category                           'Disulfide bridge' 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 2 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 4 ? 
AA5 ? 5 ? 
AA6 ? 4 ? 
AA7 ? 5 ? 
AA8 ? 5 ? 
AA9 ? 3 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? parallel      
AA5 1 2 ? parallel      
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA5 4 5 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? parallel      
AA7 1 2 ? parallel      
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
AA7 4 5 ? anti-parallel 
AA8 1 2 ? parallel      
AA8 2 3 ? anti-parallel 
AA8 3 4 ? anti-parallel 
AA8 4 5 ? anti-parallel 
AA9 1 2 ? anti-parallel 
AA9 2 3 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 GLN A 109 ? ILE A 115 ? GLN A 74  ILE A 80  
AA1 2 THR A 123 ? ILE A 129 ? THR A 88  ILE A 94  
AA2 1 THR A 195 ? ARG A 196 ? THR A 160 ARG A 161 
AA2 2 LEU A 912 ? GLY A 913 ? LEU A 902 GLY A 903 
AA3 1 LYS A 264 ? ALA A 268 ? LYS A 229 ALA A 233 
AA3 2 ILE A 275 ? GLU A 279 ? ILE A 240 GLU A 244 
AA4 1 GLN A 447 ? GLY A 453 ? GLN A 437 GLY A 443 
AA4 2 THR A 399 ? ARG A 407 ? THR A 389 ARG A 397 
AA4 3 SER A 382 ? PHE A 386 ? SER A 372 PHE A 376 
AA4 4 ALA A 494 ? LEU A 496 ? ALA A 484 LEU A 486 
AA5 1 THR A 390 ? LEU A 394 ? THR A 380 LEU A 384 
AA5 2 ALA A 502 ? PHE A 507 ? ALA A 492 PHE A 497 
AA5 3 GLU A 464 ? SER A 476 ? GLU A 454 SER A 466 
AA5 4 THR A 414 ? GLU A 422 ? THR A 404 GLU A 412 
AA5 5 GLU A 436 ? PHE A 441 ? GLU A 426 PHE A 431 
AA6 1 VAL A 578 ? LYS A 584 ? VAL A 568 LYS A 574 
AA6 2 ILE A 530 ? THR A 538 ? ILE A 520 THR A 528 
AA6 3 ILE A 514 ? PHE A 517 ? ILE A 504 PHE A 507 
AA6 4 ILE A 680 ? LEU A 681 ? ILE A 670 LEU A 671 
AA7 1 VAL A 521 ? SER A 525 ? VAL A 511 SER A 515 
AA7 2 LYS A 686 ? GLU A 692 ? LYS A 676 GLU A 682 
AA7 3 LYS A 595 ? ILE A 601 ? LYS A 585 ILE A 591 
AA7 4 VAL A 545 ? ILE A 552 ? VAL A 535 ILE A 542 
AA7 5 CYS A 567 ? PHE A 572 ? CYS A 557 PHE A 562 
AA8 1 VAL A 521 ? SER A 525 ? VAL A 511 SER A 515 
AA8 2 LYS A 686 ? GLU A 692 ? LYS A 676 GLU A 682 
AA8 3 LYS A 595 ? ILE A 601 ? LYS A 585 ILE A 591 
AA8 4 VAL A 545 ? ILE A 552 ? VAL A 535 ILE A 542 
AA8 5 ARG A 605 ? LEU A 606 ? ARG A 595 LEU A 596 
AA9 1 GLU A 608 ? MET A 609 ? GLU A 598 MET A 599 
AA9 2 GLN A 633 ? LYS A 638 ? GLN A 623 LYS A 628 
AA9 3 PHE A 623 ? LEU A 630 ? PHE A 613 LEU A 620 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ILE A 113 ? N ILE A 78  O THR A 125 ? O THR A 90  
AA2 1 2 N ARG A 196 ? N ARG A 161 O LEU A 912 ? O LEU A 902 
AA3 1 2 N ARG A 267 ? N ARG A 232 O ILE A 276 ? O ILE A 241 
AA4 1 2 O VAL A 452 ? O VAL A 442 N VAL A 400 ? N VAL A 390 
AA4 2 3 O ILE A 405 ? O ILE A 395 N PHE A 385 ? N PHE A 375 
AA4 3 4 N SER A 382 ? N SER A 372 O CYS A 495 ? O CYS A 485 
AA5 1 2 N CYS A 393 ? N CYS A 383 O THR A 505 ? O THR A 495 
AA5 2 3 O ILE A 506 ? O ILE A 496 N GLU A 464 ? N GLU A 454 
AA5 3 4 O HIS A 469 ? O HIS A 459 N ARG A 420 ? N ARG A 410 
AA5 4 5 N VAL A 417 ? N VAL A 407 O VAL A 439 ? O VAL A 429 
AA6 1 2 O VAL A 583 ? O VAL A 573 N MET A 531 ? N MET A 521 
AA6 2 3 O THR A 538 ? O THR A 528 N ILE A 514 ? N ILE A 504 
AA6 3 4 N PHE A 515 ? N PHE A 505 O ILE A 680 ? O ILE A 670 
AA7 1 2 N VAL A 524 ? N VAL A 514 O GLU A 692 ? O GLU A 682 
AA7 2 3 O ILE A 691 ? O ILE A 681 N LYS A 595 ? N LYS A 585 
AA7 3 4 O GLU A 600 ? O GLU A 590 N LYS A 550 ? N LYS A 540 
AA7 4 5 N VAL A 545 ? N VAL A 535 O PHE A 572 ? O PHE A 562 
AA8 1 2 N VAL A 524 ? N VAL A 514 O GLU A 692 ? O GLU A 682 
AA8 2 3 O ILE A 691 ? O ILE A 681 N LYS A 595 ? N LYS A 585 
AA8 3 4 O GLU A 600 ? O GLU A 590 N LYS A 550 ? N LYS A 540 
AA8 4 5 N ILE A 546 ? N ILE A 536 O ARG A 605 ? O ARG A 595 
AA9 1 2 N MET A 609 ? N MET A 599 O PHE A 636 ? O PHE A 626 
AA9 2 3 O ARG A 637 ? O ARG A 627 N THR A 624 ? N THR A 614 
# 
_pdbx_entry_details.entry_id                   9IV8 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 HIS A 124 ? ? -93.76 52.63  
2 1 SER A 191 ? ? 52.69  72.02  
3 1 SER A 529 ? ? 65.46  -0.03  
4 1 SER A 655 ? ? 71.49  -5.09  
5 1 LEU A 845 ? ? -91.32 -62.06 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9IV8 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9IV8 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  3.5 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               117748 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.4 
# 
_em_entity_assembly.id                   1 
_em_entity_assembly.parent_id            0 
_em_entity_assembly.source               RECOMBINANT 
_em_entity_assembly.type                 COMPLEX 
_em_entity_assembly.name                 'human cardiac sodium calcium exchanger NCX1' 
_em_entity_assembly.details              ? 
_em_entity_assembly.synonym              ? 
_em_entity_assembly.oligomeric_details   ? 
_em_entity_assembly.entity_id_list       1 
# 
_em_imaging.entry_id                        9IV8 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TECNAI SPHERA' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             1000 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
_em_imaging.objective_aperture              ? 
_em_imaging.microscope_serial_number        ? 
_em_imaging.microscope_version              ? 
# 
_em_vitrification.entry_id              9IV8 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9IV8 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1   1 Y 1 A MET -34 ? A MET 1   
2   1 Y 1 A TYR -33 ? A TYR 2   
3   1 Y 1 A ASN -32 ? A ASN 3   
4   1 Y 1 A MET -31 ? A MET 4   
5   1 Y 1 A ARG -30 ? A ARG 5   
6   1 Y 1 A ARG -29 ? A ARG 6   
7   1 Y 1 A LEU -28 ? A LEU 7   
8   1 Y 1 A SER -27 ? A SER 8   
9   1 Y 1 A LEU -26 ? A LEU 9   
10  1 Y 1 A SER -25 ? A SER 10  
11  1 Y 1 A PRO -24 ? A PRO 11  
12  1 Y 1 A THR -23 ? A THR 12  
13  1 Y 1 A PHE -22 ? A PHE 13  
14  1 Y 1 A SER -21 ? A SER 14  
15  1 Y 1 A MET -20 ? A MET 15  
16  1 Y 1 A GLY -19 ? A GLY 16  
17  1 Y 1 A PHE -18 ? A PHE 17  
18  1 Y 1 A HIS -17 ? A HIS 18  
19  1 Y 1 A LEU -16 ? A LEU 19  
20  1 Y 1 A LEU -15 ? A LEU 20  
21  1 Y 1 A VAL -14 ? A VAL 21  
22  1 Y 1 A THR -13 ? A THR 22  
23  1 Y 1 A VAL -12 ? A VAL 23  
24  1 Y 1 A SER -11 ? A SER 24  
25  1 Y 1 A LEU -10 ? A LEU 25  
26  1 Y 1 A LEU -9  ? A LEU 26  
27  1 Y 1 A PHE -8  ? A PHE 27  
28  1 Y 1 A SER -7  ? A SER 28  
29  1 Y 1 A HIS -6  ? A HIS 29  
30  1 Y 1 A VAL -5  ? A VAL 30  
31  1 Y 1 A ASP -4  ? A ASP 31  
32  1 Y 1 A HIS -3  ? A HIS 32  
33  1 Y 1 A VAL -2  ? A VAL 33  
34  1 Y 1 A ILE -1  ? A ILE 34  
35  1 Y 1 A ALA 0   ? A ALA 35  
36  1 Y 1 A GLU 1   ? A GLU 36  
37  1 Y 1 A THR 2   ? A THR 37  
38  1 Y 1 A GLU 3   ? A GLU 38  
39  1 Y 1 A MET 4   ? A MET 39  
40  1 Y 1 A GLU 5   ? A GLU 40  
41  1 Y 1 A GLY 6   ? A GLY 41  
42  1 Y 1 A GLU 7   ? A GLU 42  
43  1 Y 1 A GLY 8   ? A GLY 43  
44  1 Y 1 A ASN 9   ? A ASN 44  
45  1 Y 1 A GLU 10  ? A GLU 45  
46  1 Y 1 A THR 11  ? A THR 46  
47  1 Y 1 A GLY 12  ? A GLY 47  
48  1 Y 1 A GLU 13  ? A GLU 48  
49  1 Y 1 A CYS 14  ? A CYS 49  
50  1 Y 1 A THR 15  ? A THR 50  
51  1 Y 1 A GLY 16  ? A GLY 51  
52  1 Y 1 A PRO 273 ? A PRO 283 
53  1 Y 1 A SER 274 ? A SER 284 
54  1 Y 1 A SER 275 ? A SER 285 
55  1 Y 1 A LYS 276 ? A LYS 286 
56  1 Y 1 A THR 277 ? A THR 287 
57  1 Y 1 A GLU 278 ? A GLU 288 
58  1 Y 1 A ILE 279 ? A ILE 289 
59  1 Y 1 A GLU 280 ? A GLU 290 
60  1 Y 1 A MET 281 ? A MET 291 
61  1 Y 1 A ASP 282 ? A ASP 292 
62  1 Y 1 A GLY 283 ? A GLY 293 
63  1 Y 1 A LYS 284 ? A LYS 294 
64  1 Y 1 A VAL 285 ? A VAL 295 
65  1 Y 1 A VAL 286 ? A VAL 296 
66  1 Y 1 A ASN 287 ? A ASN 297 
67  1 Y 1 A SER 288 ? A SER 298 
68  1 Y 1 A HIS 289 ? A HIS 299 
69  1 Y 1 A VAL 290 ? A VAL 300 
70  1 Y 1 A GLU 291 ? A GLU 301 
71  1 Y 1 A ASN 292 ? A ASN 302 
72  1 Y 1 A PHE 293 ? A PHE 303 
73  1 Y 1 A LEU 294 ? A LEU 304 
74  1 Y 1 A ASP 295 ? A ASP 305 
75  1 Y 1 A GLY 296 ? A GLY 306 
76  1 Y 1 A ALA 297 ? A ALA 307 
77  1 Y 1 A LEU 298 ? A LEU 308 
78  1 Y 1 A VAL 299 ? A VAL 309 
79  1 Y 1 A LEU 300 ? A LEU 310 
80  1 Y 1 A GLU 301 ? A GLU 311 
81  1 Y 1 A VAL 302 ? A VAL 312 
82  1 Y 1 A ASP 303 ? A ASP 313 
83  1 Y 1 A GLU 304 ? A GLU 314 
84  1 Y 1 A ARG 305 ? A ARG 315 
85  1 Y 1 A ASP 306 ? A ASP 316 
86  1 Y 1 A GLN 307 ? A GLN 317 
87  1 Y 1 A ASP 308 ? A ASP 318 
88  1 Y 1 A ASP 309 ? A ASP 319 
89  1 Y 1 A GLU 310 ? A GLU 320 
90  1 Y 1 A GLU 311 ? A GLU 321 
91  1 Y 1 A ALA 312 ? A ALA 322 
92  1 Y 1 A ARG 313 ? A ARG 323 
93  1 Y 1 A ARG 314 ? A ARG 324 
94  1 Y 1 A GLU 315 ? A GLU 325 
95  1 Y 1 A MET 316 ? A MET 326 
96  1 Y 1 A ALA 317 ? A ALA 327 
97  1 Y 1 A ARG 318 ? A ARG 328 
98  1 Y 1 A ILE 319 ? A ILE 329 
99  1 Y 1 A LEU 320 ? A LEU 330 
100 1 Y 1 A LYS 321 ? A LYS 331 
101 1 Y 1 A GLU 322 ? A GLU 332 
102 1 Y 1 A LEU 323 ? A LEU 333 
103 1 Y 1 A LYS 324 ? A LYS 334 
104 1 Y 1 A GLN 325 ? A GLN 335 
105 1 Y 1 A LYS 326 ? A LYS 336 
106 1 Y 1 A HIS 327 ? A HIS 337 
107 1 Y 1 A PRO 328 ? A PRO 338 
108 1 Y 1 A ASP 329 ? A ASP 339 
109 1 Y 1 A LYS 330 ? A LYS 340 
110 1 Y 1 A GLU 331 ? A GLU 341 
111 1 Y 1 A ILE 332 ? A ILE 342 
112 1 Y 1 A GLU 333 ? A GLU 343 
113 1 Y 1 A GLN 334 ? A GLN 344 
114 1 Y 1 A LEU 335 ? A LEU 345 
115 1 Y 1 A ILE 336 ? A ILE 346 
116 1 Y 1 A GLU 337 ? A GLU 347 
117 1 Y 1 A LEU 338 ? A LEU 348 
118 1 Y 1 A ALA 339 ? A ALA 349 
119 1 Y 1 A ASN 340 ? A ASN 350 
120 1 Y 1 A TYR 341 ? A TYR 351 
121 1 Y 1 A GLN 342 ? A GLN 352 
122 1 Y 1 A VAL 343 ? A VAL 353 
123 1 Y 1 A LEU 344 ? A LEU 354 
124 1 Y 1 A SER 345 ? A SER 355 
125 1 Y 1 A GLN 346 ? A GLN 356 
126 1 Y 1 A GLN 347 ? A GLN 357 
127 1 Y 1 A GLN 348 ? A GLN 358 
128 1 Y 1 A LYS 349 ? A LYS 359 
129 1 Y 1 A SER 350 ? A SER 360 
130 1 Y 1 A ARG 351 ? A ARG 361 
131 1 Y 1 A ALA 352 ? A ALA 362 
132 1 Y 1 A PHE 353 ? A PHE 363 
133 1 Y 1 A TYR 354 ? A TYR 364 
134 1 Y 1 A ARG 355 ? A ARG 365 
135 1 Y 1 A ILE 356 ? A ILE 366 
136 1 Y 1 A GLN 357 ? A GLN 367 
137 1 Y 1 A ALA 358 ? A ALA 368 
138 1 Y 1 A THR 359 ? A THR 369 
139 1 Y 1 A ARG 360 ? A ARG 370 
140 1 Y 1 A LEU 361 ? A LEU 371 
141 1 Y 1 A MET 362 ? A MET 372 
142 1 Y 1 A THR 363 ? A THR 373 
143 1 Y 1 A GLY 364 ? A GLY 374 
144 1 Y 1 A ALA 365 ? A ALA 375 
145 1 Y 1 A THR 366 ? A THR 376 
146 1 Y 1 A GLU 367 ? A GLU 377 
147 1 Y 1 A ASN 368 ? A ASN 378 
148 1 Y 1 A ASP 369 ? A ASP 379 
149 1 Y 1 A GLU 468 ? A GLU 478 
150 1 Y 1 A ALA 469 ? A ALA 479 
151 1 Y 1 A SER 470 ? A SER 480 
152 1 Y 1 A GLU 471 ? A GLU 481 
153 1 Y 1 A ASP 472 ? A ASP 482 
154 1 Y 1 A GLY 473 ? A GLY 483 
155 1 Y 1 A ILE 474 ? A ILE 484 
156 1 Y 1 A LEU 475 ? A LEU 485 
157 1 Y 1 A GLU 476 ? A GLU 486 
158 1 Y 1 A ALA 477 ? A ALA 487 
159 1 Y 1 A ASN 478 ? A ASN 488 
160 1 Y 1 A HIS 479 ? A HIS 489 
161 1 Y 1 A VAL 480 ? A VAL 490 
162 1 Y 1 A SER 481 ? A SER 491 
163 1 Y 1 A ASP 645 ? A ASP 655 
164 1 Y 1 A GLU 646 ? A GLU 656 
165 1 Y 1 A TYR 647 ? A TYR 657 
166 1 Y 1 A ASP 648 ? A ASP 658 
167 1 Y 1 A ASP 649 ? A ASP 659 
168 1 Y 1 A LYS 650 ? A LYS 660 
169 1 Y 1 A GLN 651 ? A GLN 661 
170 1 Y 1 A ASN 699 ? A ASN 709 
171 1 Y 1 A LEU 700 ? A LEU 710 
172 1 Y 1 A ALA 701 ? A ALA 711 
173 1 Y 1 A LEU 702 ? A LEU 712 
174 1 Y 1 A VAL 703 ? A VAL 713 
175 1 Y 1 A VAL 704 ? A VAL 714 
176 1 Y 1 A GLY 705 ? A GLY 715 
177 1 Y 1 A THR 706 ? A THR 716 
178 1 Y 1 A VAL 719 ? A VAL 729 
179 1 Y 1 A SER 720 ? A SER 730 
180 1 Y 1 A ALA 721 ? A ALA 731 
181 1 Y 1 A GLY 722 ? A GLY 732 
182 1 Y 1 A GLU 723 ? A GLU 733 
183 1 Y 1 A ASP 724 ? A ASP 734 
184 1 Y 1 A ASP 725 ? A ASP 735 
185 1 Y 1 A ASP 726 ? A ASP 736 
186 1 Y 1 A ASP 727 ? A ASP 737 
187 1 Y 1 A ASP 728 ? A ASP 738 
188 1 Y 1 A GLU 729 ? A GLU 739 
189 1 Y 1 A CYS 730 ? A CYS 740 
190 1 Y 1 A GLY 731 ? A GLY 741 
191 1 Y 1 A GLU 732 ? A GLU 742 
192 1 Y 1 A GLU 733 ? A GLU 743 
193 1 Y 1 A LYS 734 ? A LYS 744 
194 1 Y 1 A LEU 735 ? A LEU 745 
195 1 Y 1 A PRO 736 ? A PRO 746 
196 1 Y 1 A LYS 936 ? A LYS 946 
197 1 Y 1 A GLY 937 ? A GLY 947 
198 1 Y 1 A PHE 938 ? A PHE 948 
199 1 Y 1 A ALA 939 ? A ALA 949 
200 1 Y 1 A ALA 940 ? A ALA 950 
201 1 Y 1 A ALA 941 ? A ALA 951 
202 1 Y 1 A GLY 942 ? A GLY 952 
203 1 Y 1 A GLY 943 ? A GLY 953 
204 1 Y 1 A SER 944 ? A SER 954 
205 1 Y 1 A TRP 945 ? A TRP 955 
206 1 Y 1 A SER 946 ? A SER 956 
207 1 Y 1 A HIS 947 ? A HIS 957 
208 1 Y 1 A PRO 948 ? A PRO 958 
209 1 Y 1 A GLN 949 ? A GLN 959 
210 1 Y 1 A PHE 950 ? A PHE 960 
211 1 Y 1 A GLU 951 ? A GLU 961 
212 1 Y 1 A LYS 952 ? A LYS 962 
213 1 Y 1 A GLY 953 ? A GLY 963 
214 1 Y 1 A GLY 954 ? A GLY 964 
215 1 Y 1 A GLY 955 ? A GLY 965 
216 1 Y 1 A SER 956 ? A SER 966 
217 1 Y 1 A GLY 957 ? A GLY 967 
218 1 Y 1 A GLY 958 ? A GLY 968 
219 1 Y 1 A GLY 959 ? A GLY 969 
220 1 Y 1 A SER 960 ? A SER 970 
221 1 Y 1 A GLY 961 ? A GLY 971 
222 1 Y 1 A GLY 962 ? A GLY 972 
223 1 Y 1 A SER 963 ? A SER 973 
224 1 Y 1 A ALA 964 ? A ALA 974 
225 1 Y 1 A TRP 965 ? A TRP 975 
226 1 Y 1 A SER 966 ? A SER 976 
227 1 Y 1 A HIS 967 ? A HIS 977 
228 1 Y 1 A PRO 968 ? A PRO 978 
229 1 Y 1 A GLN 969 ? A GLN 979 
230 1 Y 1 A PHE 970 ? A PHE 980 
231 1 Y 1 A GLU 971 ? A GLU 981 
232 1 Y 1 A LYS 972 ? A LYS 982 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CA  CA   CA N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
GLN N    N  N N 89  
GLN CA   C  N S 90  
GLN C    C  N N 91  
GLN O    O  N N 92  
GLN CB   C  N N 93  
GLN CG   C  N N 94  
GLN CD   C  N N 95  
GLN OE1  O  N N 96  
GLN NE2  N  N N 97  
GLN OXT  O  N N 98  
GLN H    H  N N 99  
GLN H2   H  N N 100 
GLN HA   H  N N 101 
GLN HB2  H  N N 102 
GLN HB3  H  N N 103 
GLN HG2  H  N N 104 
GLN HG3  H  N N 105 
GLN HE21 H  N N 106 
GLN HE22 H  N N 107 
GLN HXT  H  N N 108 
GLU N    N  N N 109 
GLU CA   C  N S 110 
GLU C    C  N N 111 
GLU O    O  N N 112 
GLU CB   C  N N 113 
GLU CG   C  N N 114 
GLU CD   C  N N 115 
GLU OE1  O  N N 116 
GLU OE2  O  N N 117 
GLU OXT  O  N N 118 
GLU H    H  N N 119 
GLU H2   H  N N 120 
GLU HA   H  N N 121 
GLU HB2  H  N N 122 
GLU HB3  H  N N 123 
GLU HG2  H  N N 124 
GLU HG3  H  N N 125 
GLU HE2  H  N N 126 
GLU HXT  H  N N 127 
GLY N    N  N N 128 
GLY CA   C  N N 129 
GLY C    C  N N 130 
GLY O    O  N N 131 
GLY OXT  O  N N 132 
GLY H    H  N N 133 
GLY H2   H  N N 134 
GLY HA2  H  N N 135 
GLY HA3  H  N N 136 
GLY HXT  H  N N 137 
HIS N    N  N N 138 
HIS CA   C  N S 139 
HIS C    C  N N 140 
HIS O    O  N N 141 
HIS CB   C  N N 142 
HIS CG   C  Y N 143 
HIS ND1  N  Y N 144 
HIS CD2  C  Y N 145 
HIS CE1  C  Y N 146 
HIS NE2  N  Y N 147 
HIS OXT  O  N N 148 
HIS H    H  N N 149 
HIS H2   H  N N 150 
HIS HA   H  N N 151 
HIS HB2  H  N N 152 
HIS HB3  H  N N 153 
HIS HD1  H  N N 154 
HIS HD2  H  N N 155 
HIS HE1  H  N N 156 
HIS HE2  H  N N 157 
HIS HXT  H  N N 158 
ILE N    N  N N 159 
ILE CA   C  N S 160 
ILE C    C  N N 161 
ILE O    O  N N 162 
ILE CB   C  N S 163 
ILE CG1  C  N N 164 
ILE CG2  C  N N 165 
ILE CD1  C  N N 166 
ILE OXT  O  N N 167 
ILE H    H  N N 168 
ILE H2   H  N N 169 
ILE HA   H  N N 170 
ILE HB   H  N N 171 
ILE HG12 H  N N 172 
ILE HG13 H  N N 173 
ILE HG21 H  N N 174 
ILE HG22 H  N N 175 
ILE HG23 H  N N 176 
ILE HD11 H  N N 177 
ILE HD12 H  N N 178 
ILE HD13 H  N N 179 
ILE HXT  H  N N 180 
LEU N    N  N N 181 
LEU CA   C  N S 182 
LEU C    C  N N 183 
LEU O    O  N N 184 
LEU CB   C  N N 185 
LEU CG   C  N N 186 
LEU CD1  C  N N 187 
LEU CD2  C  N N 188 
LEU OXT  O  N N 189 
LEU H    H  N N 190 
LEU H2   H  N N 191 
LEU HA   H  N N 192 
LEU HB2  H  N N 193 
LEU HB3  H  N N 194 
LEU HG   H  N N 195 
LEU HD11 H  N N 196 
LEU HD12 H  N N 197 
LEU HD13 H  N N 198 
LEU HD21 H  N N 199 
LEU HD22 H  N N 200 
LEU HD23 H  N N 201 
LEU HXT  H  N N 202 
LYS N    N  N N 203 
LYS CA   C  N S 204 
LYS C    C  N N 205 
LYS O    O  N N 206 
LYS CB   C  N N 207 
LYS CG   C  N N 208 
LYS CD   C  N N 209 
LYS CE   C  N N 210 
LYS NZ   N  N N 211 
LYS OXT  O  N N 212 
LYS H    H  N N 213 
LYS H2   H  N N 214 
LYS HA   H  N N 215 
LYS HB2  H  N N 216 
LYS HB3  H  N N 217 
LYS HG2  H  N N 218 
LYS HG3  H  N N 219 
LYS HD2  H  N N 220 
LYS HD3  H  N N 221 
LYS HE2  H  N N 222 
LYS HE3  H  N N 223 
LYS HZ1  H  N N 224 
LYS HZ2  H  N N 225 
LYS HZ3  H  N N 226 
LYS HXT  H  N N 227 
MET N    N  N N 228 
MET CA   C  N S 229 
MET C    C  N N 230 
MET O    O  N N 231 
MET CB   C  N N 232 
MET CG   C  N N 233 
MET SD   S  N N 234 
MET CE   C  N N 235 
MET OXT  O  N N 236 
MET H    H  N N 237 
MET H2   H  N N 238 
MET HA   H  N N 239 
MET HB2  H  N N 240 
MET HB3  H  N N 241 
MET HG2  H  N N 242 
MET HG3  H  N N 243 
MET HE1  H  N N 244 
MET HE2  H  N N 245 
MET HE3  H  N N 246 
MET HXT  H  N N 247 
PHE N    N  N N 248 
PHE CA   C  N S 249 
PHE C    C  N N 250 
PHE O    O  N N 251 
PHE CB   C  N N 252 
PHE CG   C  Y N 253 
PHE CD1  C  Y N 254 
PHE CD2  C  Y N 255 
PHE CE1  C  Y N 256 
PHE CE2  C  Y N 257 
PHE CZ   C  Y N 258 
PHE OXT  O  N N 259 
PHE H    H  N N 260 
PHE H2   H  N N 261 
PHE HA   H  N N 262 
PHE HB2  H  N N 263 
PHE HB3  H  N N 264 
PHE HD1  H  N N 265 
PHE HD2  H  N N 266 
PHE HE1  H  N N 267 
PHE HE2  H  N N 268 
PHE HZ   H  N N 269 
PHE HXT  H  N N 270 
PIO C1   C  N R 271 
PIO O1   O  N N 272 
PIO P1   P  N N 273 
PIO C2   C  N R 274 
PIO O2   O  N N 275 
PIO C3   C  N S 276 
PIO O3   O  N N 277 
PIO C4   C  N R 278 
PIO O4   O  N N 279 
PIO P4   P  N N 280 
PIO C5   C  N R 281 
PIO O5   O  N N 282 
PIO P5   P  N N 283 
PIO C6   C  N S 284 
PIO O6   O  N N 285 
PIO O11  O  N N 286 
PIO O12  O  N N 287 
PIO O13  O  N N 288 
PIO C1A  C  N N 289 
PIO O1A  O  N N 290 
PIO C1B  C  N N 291 
PIO O1B  O  N N 292 
PIO C1C  C  N N 293 
PIO C2A  C  N N 294 
PIO C2B  C  N N 295 
PIO C2C  C  N R 296 
PIO O2C  O  N N 297 
PIO C3A  C  N N 298 
PIO C3B  C  N N 299 
PIO C3C  C  N N 300 
PIO O3C  O  N N 301 
PIO O41  O  N N 302 
PIO O42  O  N N 303 
PIO O43  O  N N 304 
PIO C4A  C  N N 305 
PIO C4B  C  N N 306 
PIO O51  O  N N 307 
PIO O52  O  N N 308 
PIO O53  O  N N 309 
PIO C5A  C  N N 310 
PIO C5B  C  N N 311 
PIO C6A  C  N N 312 
PIO C6B  C  N N 313 
PIO C7A  C  N N 314 
PIO C7B  C  N N 315 
PIO C8A  C  N N 316 
PIO C8B  C  N N 317 
PIO H1   H  N N 318 
PIO H2   H  N N 319 
PIO H3   H  N N 320 
PIO H4   H  N N 321 
PIO H5   H  N N 322 
PIO H6   H  N N 323 
PIO H1C  H  N N 324 
PIO H1CA H  N N 325 
PIO H3C  H  N N 326 
PIO H3CA H  N N 327 
PIO H2A  H  N N 328 
PIO H3A  H  N N 329 
PIO H4A  H  N N 330 
PIO H5A  H  N N 331 
PIO H6A  H  N N 332 
PIO H7A  H  N N 333 
PIO H8A  H  N N 334 
PIO H2AA H  N N 335 
PIO H3AA H  N N 336 
PIO H4AA H  N N 337 
PIO H5AA H  N N 338 
PIO H6AA H  N N 339 
PIO H7AA H  N N 340 
PIO H8AA H  N N 341 
PIO H8AB H  N N 342 
PIO H2B  H  N N 343 
PIO H3B  H  N N 344 
PIO H4B  H  N N 345 
PIO H5B  H  N N 346 
PIO H6B  H  N N 347 
PIO H7B  H  N N 348 
PIO H8B  H  N N 349 
PIO H2BA H  N N 350 
PIO H3BA H  N N 351 
PIO H4BA H  N N 352 
PIO H5BA H  N N 353 
PIO H6BA H  N N 354 
PIO H7BA H  N N 355 
PIO H8BA H  N N 356 
PIO H8BB H  N N 357 
PIO H2C  H  N N 358 
PIO HO2  H  N N 359 
PIO HO3  H  N N 360 
PIO HO6  H  N N 361 
PIO H41  H  N N 362 
PIO H43  H  N N 363 
PIO H51  H  N N 364 
PIO H52  H  N N 365 
PIO H11  H  N N 366 
PRO N    N  N N 367 
PRO CA   C  N S 368 
PRO C    C  N N 369 
PRO O    O  N N 370 
PRO CB   C  N N 371 
PRO CG   C  N N 372 
PRO CD   C  N N 373 
PRO OXT  O  N N 374 
PRO H    H  N N 375 
PRO HA   H  N N 376 
PRO HB2  H  N N 377 
PRO HB3  H  N N 378 
PRO HG2  H  N N 379 
PRO HG3  H  N N 380 
PRO HD2  H  N N 381 
PRO HD3  H  N N 382 
PRO HXT  H  N N 383 
SER N    N  N N 384 
SER CA   C  N S 385 
SER C    C  N N 386 
SER O    O  N N 387 
SER CB   C  N N 388 
SER OG   O  N N 389 
SER OXT  O  N N 390 
SER H    H  N N 391 
SER H2   H  N N 392 
SER HA   H  N N 393 
SER HB2  H  N N 394 
SER HB3  H  N N 395 
SER HG   H  N N 396 
SER HXT  H  N N 397 
THR N    N  N N 398 
THR CA   C  N S 399 
THR C    C  N N 400 
THR O    O  N N 401 
THR CB   C  N R 402 
THR OG1  O  N N 403 
THR CG2  C  N N 404 
THR OXT  O  N N 405 
THR H    H  N N 406 
THR H2   H  N N 407 
THR HA   H  N N 408 
THR HB   H  N N 409 
THR HG1  H  N N 410 
THR HG21 H  N N 411 
THR HG22 H  N N 412 
THR HG23 H  N N 413 
THR HXT  H  N N 414 
TRP N    N  N N 415 
TRP CA   C  N S 416 
TRP C    C  N N 417 
TRP O    O  N N 418 
TRP CB   C  N N 419 
TRP CG   C  Y N 420 
TRP CD1  C  Y N 421 
TRP CD2  C  Y N 422 
TRP NE1  N  Y N 423 
TRP CE2  C  Y N 424 
TRP CE3  C  Y N 425 
TRP CZ2  C  Y N 426 
TRP CZ3  C  Y N 427 
TRP CH2  C  Y N 428 
TRP OXT  O  N N 429 
TRP H    H  N N 430 
TRP H2   H  N N 431 
TRP HA   H  N N 432 
TRP HB2  H  N N 433 
TRP HB3  H  N N 434 
TRP HD1  H  N N 435 
TRP HE1  H  N N 436 
TRP HE3  H  N N 437 
TRP HZ2  H  N N 438 
TRP HZ3  H  N N 439 
TRP HH2  H  N N 440 
TRP HXT  H  N N 441 
TYR N    N  N N 442 
TYR CA   C  N S 443 
TYR C    C  N N 444 
TYR O    O  N N 445 
TYR CB   C  N N 446 
TYR CG   C  Y N 447 
TYR CD1  C  Y N 448 
TYR CD2  C  Y N 449 
TYR CE1  C  Y N 450 
TYR CE2  C  Y N 451 
TYR CZ   C  Y N 452 
TYR OH   O  N N 453 
TYR OXT  O  N N 454 
TYR H    H  N N 455 
TYR H2   H  N N 456 
TYR HA   H  N N 457 
TYR HB2  H  N N 458 
TYR HB3  H  N N 459 
TYR HD1  H  N N 460 
TYR HD2  H  N N 461 
TYR HE1  H  N N 462 
TYR HE2  H  N N 463 
TYR HH   H  N N 464 
TYR HXT  H  N N 465 
VAL N    N  N N 466 
VAL CA   C  N S 467 
VAL C    C  N N 468 
VAL O    O  N N 469 
VAL CB   C  N N 470 
VAL CG1  C  N N 471 
VAL CG2  C  N N 472 
VAL OXT  O  N N 473 
VAL H    H  N N 474 
VAL H2   H  N N 475 
VAL HA   H  N N 476 
VAL HB   H  N N 477 
VAL HG11 H  N N 478 
VAL HG12 H  N N 479 
VAL HG13 H  N N 480 
VAL HG21 H  N N 481 
VAL HG22 H  N N 482 
VAL HG23 H  N N 483 
VAL HXT  H  N N 484 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
ILE N   CA   sing N N 150 
ILE N   H    sing N N 151 
ILE N   H2   sing N N 152 
ILE CA  C    sing N N 153 
ILE CA  CB   sing N N 154 
ILE CA  HA   sing N N 155 
ILE C   O    doub N N 156 
ILE C   OXT  sing N N 157 
ILE CB  CG1  sing N N 158 
ILE CB  CG2  sing N N 159 
ILE CB  HB   sing N N 160 
ILE CG1 CD1  sing N N 161 
ILE CG1 HG12 sing N N 162 
ILE CG1 HG13 sing N N 163 
ILE CG2 HG21 sing N N 164 
ILE CG2 HG22 sing N N 165 
ILE CG2 HG23 sing N N 166 
ILE CD1 HD11 sing N N 167 
ILE CD1 HD12 sing N N 168 
ILE CD1 HD13 sing N N 169 
ILE OXT HXT  sing N N 170 
LEU N   CA   sing N N 171 
LEU N   H    sing N N 172 
LEU N   H2   sing N N 173 
LEU CA  C    sing N N 174 
LEU CA  CB   sing N N 175 
LEU CA  HA   sing N N 176 
LEU C   O    doub N N 177 
LEU C   OXT  sing N N 178 
LEU CB  CG   sing N N 179 
LEU CB  HB2  sing N N 180 
LEU CB  HB3  sing N N 181 
LEU CG  CD1  sing N N 182 
LEU CG  CD2  sing N N 183 
LEU CG  HG   sing N N 184 
LEU CD1 HD11 sing N N 185 
LEU CD1 HD12 sing N N 186 
LEU CD1 HD13 sing N N 187 
LEU CD2 HD21 sing N N 188 
LEU CD2 HD22 sing N N 189 
LEU CD2 HD23 sing N N 190 
LEU OXT HXT  sing N N 191 
LYS N   CA   sing N N 192 
LYS N   H    sing N N 193 
LYS N   H2   sing N N 194 
LYS CA  C    sing N N 195 
LYS CA  CB   sing N N 196 
LYS CA  HA   sing N N 197 
LYS C   O    doub N N 198 
LYS C   OXT  sing N N 199 
LYS CB  CG   sing N N 200 
LYS CB  HB2  sing N N 201 
LYS CB  HB3  sing N N 202 
LYS CG  CD   sing N N 203 
LYS CG  HG2  sing N N 204 
LYS CG  HG3  sing N N 205 
LYS CD  CE   sing N N 206 
LYS CD  HD2  sing N N 207 
LYS CD  HD3  sing N N 208 
LYS CE  NZ   sing N N 209 
LYS CE  HE2  sing N N 210 
LYS CE  HE3  sing N N 211 
LYS NZ  HZ1  sing N N 212 
LYS NZ  HZ2  sing N N 213 
LYS NZ  HZ3  sing N N 214 
LYS OXT HXT  sing N N 215 
MET N   CA   sing N N 216 
MET N   H    sing N N 217 
MET N   H2   sing N N 218 
MET CA  C    sing N N 219 
MET CA  CB   sing N N 220 
MET CA  HA   sing N N 221 
MET C   O    doub N N 222 
MET C   OXT  sing N N 223 
MET CB  CG   sing N N 224 
MET CB  HB2  sing N N 225 
MET CB  HB3  sing N N 226 
MET CG  SD   sing N N 227 
MET CG  HG2  sing N N 228 
MET CG  HG3  sing N N 229 
MET SD  CE   sing N N 230 
MET CE  HE1  sing N N 231 
MET CE  HE2  sing N N 232 
MET CE  HE3  sing N N 233 
MET OXT HXT  sing N N 234 
PHE N   CA   sing N N 235 
PHE N   H    sing N N 236 
PHE N   H2   sing N N 237 
PHE CA  C    sing N N 238 
PHE CA  CB   sing N N 239 
PHE CA  HA   sing N N 240 
PHE C   O    doub N N 241 
PHE C   OXT  sing N N 242 
PHE CB  CG   sing N N 243 
PHE CB  HB2  sing N N 244 
PHE CB  HB3  sing N N 245 
PHE CG  CD1  doub Y N 246 
PHE CG  CD2  sing Y N 247 
PHE CD1 CE1  sing Y N 248 
PHE CD1 HD1  sing N N 249 
PHE CD2 CE2  doub Y N 250 
PHE CD2 HD2  sing N N 251 
PHE CE1 CZ   doub Y N 252 
PHE CE1 HE1  sing N N 253 
PHE CE2 CZ   sing Y N 254 
PHE CE2 HE2  sing N N 255 
PHE CZ  HZ   sing N N 256 
PHE OXT HXT  sing N N 257 
PIO C1  O1   sing N N 258 
PIO C1  C2   sing N N 259 
PIO C1  C6   sing N N 260 
PIO C1  H1   sing N N 261 
PIO O1  P1   sing N N 262 
PIO P1  O11  sing N N 263 
PIO O11 H11  sing N N 264 
PIO P1  O12  doub N N 265 
PIO P1  O13  sing N N 266 
PIO C2  O2   sing N N 267 
PIO C2  C3   sing N N 268 
PIO C2  H2   sing N N 269 
PIO O2  HO2  sing N N 270 
PIO C3  O3   sing N N 271 
PIO C3  C4   sing N N 272 
PIO C3  H3   sing N N 273 
PIO O3  HO3  sing N N 274 
PIO C4  O4   sing N N 275 
PIO C4  C5   sing N N 276 
PIO C4  H4   sing N N 277 
PIO O4  P4   sing N N 278 
PIO P4  O41  sing N N 279 
PIO O41 H41  sing N N 280 
PIO P4  O42  doub N N 281 
PIO P4  O43  sing N N 282 
PIO O43 H43  sing N N 283 
PIO C5  O5   sing N N 284 
PIO C5  C6   sing N N 285 
PIO C5  H5   sing N N 286 
PIO O5  P5   sing N N 287 
PIO P5  O51  sing N N 288 
PIO O51 H51  sing N N 289 
PIO P5  O52  sing N N 290 
PIO O52 H52  sing N N 291 
PIO P5  O53  doub N N 292 
PIO C6  O6   sing N N 293 
PIO C6  H6   sing N N 294 
PIO O6  HO6  sing N N 295 
PIO O13 C1C  sing N N 296 
PIO C1A O1A  doub N N 297 
PIO C1A C2A  sing N N 298 
PIO C1A O2C  sing N N 299 
PIO C1B O1B  doub N N 300 
PIO C1B C2B  sing N N 301 
PIO C1B O3C  sing N N 302 
PIO C1C C2C  sing N N 303 
PIO C1C H1C  sing N N 304 
PIO C1C H1CA sing N N 305 
PIO C2A C3A  sing N N 306 
PIO C2A H2A  sing N N 307 
PIO C2A H2AA sing N N 308 
PIO C2B C3B  sing N N 309 
PIO C2B H2B  sing N N 310 
PIO C2B H2BA sing N N 311 
PIO C2C O2C  sing N N 312 
PIO C2C C3C  sing N N 313 
PIO C2C H2C  sing N N 314 
PIO C3A C4A  sing N N 315 
PIO C3A H3A  sing N N 316 
PIO C3A H3AA sing N N 317 
PIO C3B C4B  sing N N 318 
PIO C3B H3B  sing N N 319 
PIO C3B H3BA sing N N 320 
PIO C3C O3C  sing N N 321 
PIO C3C H3C  sing N N 322 
PIO C3C H3CA sing N N 323 
PIO C4A C5A  sing N N 324 
PIO C4A H4A  sing N N 325 
PIO C4A H4AA sing N N 326 
PIO C4B C5B  sing N N 327 
PIO C4B H4B  sing N N 328 
PIO C4B H4BA sing N N 329 
PIO C5A C6A  sing N N 330 
PIO C5A H5A  sing N N 331 
PIO C5A H5AA sing N N 332 
PIO C5B C6B  sing N N 333 
PIO C5B H5B  sing N N 334 
PIO C5B H5BA sing N N 335 
PIO C6A C7A  sing N N 336 
PIO C6A H6A  sing N N 337 
PIO C6A H6AA sing N N 338 
PIO C6B C7B  sing N N 339 
PIO C6B H6B  sing N N 340 
PIO C6B H6BA sing N N 341 
PIO C7A C8A  sing N N 342 
PIO C7A H7A  sing N N 343 
PIO C7A H7AA sing N N 344 
PIO C7B C8B  sing N N 345 
PIO C7B H7B  sing N N 346 
PIO C7B H7BA sing N N 347 
PIO C8A H8A  sing N N 348 
PIO C8A H8AA sing N N 349 
PIO C8A H8AB sing N N 350 
PIO C8B H8B  sing N N 351 
PIO C8B H8BA sing N N 352 
PIO C8B H8BB sing N N 353 
PRO N   CA   sing N N 354 
PRO N   CD   sing N N 355 
PRO N   H    sing N N 356 
PRO CA  C    sing N N 357 
PRO CA  CB   sing N N 358 
PRO CA  HA   sing N N 359 
PRO C   O    doub N N 360 
PRO C   OXT  sing N N 361 
PRO CB  CG   sing N N 362 
PRO CB  HB2  sing N N 363 
PRO CB  HB3  sing N N 364 
PRO CG  CD   sing N N 365 
PRO CG  HG2  sing N N 366 
PRO CG  HG3  sing N N 367 
PRO CD  HD2  sing N N 368 
PRO CD  HD3  sing N N 369 
PRO OXT HXT  sing N N 370 
SER N   CA   sing N N 371 
SER N   H    sing N N 372 
SER N   H2   sing N N 373 
SER CA  C    sing N N 374 
SER CA  CB   sing N N 375 
SER CA  HA   sing N N 376 
SER C   O    doub N N 377 
SER C   OXT  sing N N 378 
SER CB  OG   sing N N 379 
SER CB  HB2  sing N N 380 
SER CB  HB3  sing N N 381 
SER OG  HG   sing N N 382 
SER OXT HXT  sing N N 383 
THR N   CA   sing N N 384 
THR N   H    sing N N 385 
THR N   H2   sing N N 386 
THR CA  C    sing N N 387 
THR CA  CB   sing N N 388 
THR CA  HA   sing N N 389 
THR C   O    doub N N 390 
THR C   OXT  sing N N 391 
THR CB  OG1  sing N N 392 
THR CB  CG2  sing N N 393 
THR CB  HB   sing N N 394 
THR OG1 HG1  sing N N 395 
THR CG2 HG21 sing N N 396 
THR CG2 HG22 sing N N 397 
THR CG2 HG23 sing N N 398 
THR OXT HXT  sing N N 399 
TRP N   CA   sing N N 400 
TRP N   H    sing N N 401 
TRP N   H2   sing N N 402 
TRP CA  C    sing N N 403 
TRP CA  CB   sing N N 404 
TRP CA  HA   sing N N 405 
TRP C   O    doub N N 406 
TRP C   OXT  sing N N 407 
TRP CB  CG   sing N N 408 
TRP CB  HB2  sing N N 409 
TRP CB  HB3  sing N N 410 
TRP CG  CD1  doub Y N 411 
TRP CG  CD2  sing Y N 412 
TRP CD1 NE1  sing Y N 413 
TRP CD1 HD1  sing N N 414 
TRP CD2 CE2  doub Y N 415 
TRP CD2 CE3  sing Y N 416 
TRP NE1 CE2  sing Y N 417 
TRP NE1 HE1  sing N N 418 
TRP CE2 CZ2  sing Y N 419 
TRP CE3 CZ3  doub Y N 420 
TRP CE3 HE3  sing N N 421 
TRP CZ2 CH2  doub Y N 422 
TRP CZ2 HZ2  sing N N 423 
TRP CZ3 CH2  sing Y N 424 
TRP CZ3 HZ3  sing N N 425 
TRP CH2 HH2  sing N N 426 
TRP OXT HXT  sing N N 427 
TYR N   CA   sing N N 428 
TYR N   H    sing N N 429 
TYR N   H2   sing N N 430 
TYR CA  C    sing N N 431 
TYR CA  CB   sing N N 432 
TYR CA  HA   sing N N 433 
TYR C   O    doub N N 434 
TYR C   OXT  sing N N 435 
TYR CB  CG   sing N N 436 
TYR CB  HB2  sing N N 437 
TYR CB  HB3  sing N N 438 
TYR CG  CD1  doub Y N 439 
TYR CG  CD2  sing Y N 440 
TYR CD1 CE1  sing Y N 441 
TYR CD1 HD1  sing N N 442 
TYR CD2 CE2  doub Y N 443 
TYR CD2 HD2  sing N N 444 
TYR CE1 CZ   doub Y N 445 
TYR CE1 HE1  sing N N 446 
TYR CE2 CZ   sing Y N 447 
TYR CE2 HE2  sing N N 448 
TYR CZ  OH   sing N N 449 
TYR OH  HH   sing N N 450 
TYR OXT HXT  sing N N 451 
VAL N   CA   sing N N 452 
VAL N   H    sing N N 453 
VAL N   H2   sing N N 454 
VAL CA  C    sing N N 455 
VAL CA  CB   sing N N 456 
VAL CA  HA   sing N N 457 
VAL C   O    doub N N 458 
VAL C   OXT  sing N N 459 
VAL CB  CG1  sing N N 460 
VAL CB  CG2  sing N N 461 
VAL CB  HB   sing N N 462 
VAL CG1 HG11 sing N N 463 
VAL CG1 HG12 sing N N 464 
VAL CG1 HG13 sing N N 465 
VAL CG2 HG21 sing N N 466 
VAL CG2 HG22 sing N N 467 
VAL CG2 HG23 sing N N 468 
VAL OXT HXT  sing N N 469 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-07-23 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           9IV8 
_em_admin.last_update        2025-06-04 
_em_admin.map_release_date   2025-03-19 
_em_admin.title              'Cryo-EM structure of human NCX1 in PIP2 diC8 bound state' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     NONE 
# 
_em_entity_assembly_molwt.entity_assembly_id   1 
_em_entity_assembly_molwt.experimental_flag    NO 
_em_entity_assembly_molwt.id                   1 
_em_entity_assembly_molwt.units                ? 
_em_entity_assembly_molwt.value                ? 
# 
_em_entity_assembly_naturalsource.cell                 ? 
_em_entity_assembly_naturalsource.cellular_location    ? 
_em_entity_assembly_naturalsource.entity_assembly_id   1 
_em_entity_assembly_naturalsource.id                   1 
_em_entity_assembly_naturalsource.ncbi_tax_id          9606 
_em_entity_assembly_naturalsource.organism             'Homo sapiens' 
_em_entity_assembly_naturalsource.organelle            ? 
_em_entity_assembly_naturalsource.organ                ? 
_em_entity_assembly_naturalsource.strain               ? 
_em_entity_assembly_naturalsource.tissue               ? 
_em_entity_assembly_naturalsource.details              ? 
# 
_em_entity_assembly_recombinant.cell                 ? 
_em_entity_assembly_recombinant.entity_assembly_id   1 
_em_entity_assembly_recombinant.id                   1 
_em_entity_assembly_recombinant.ncbi_tax_id          9606 
_em_entity_assembly_recombinant.organism             'Homo sapiens' 
_em_entity_assembly_recombinant.plasmid              ? 
_em_entity_assembly_recombinant.strain               ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         60 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'FEI FALCON IV (4k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'            ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'             ? 2  ? ? 1 ? ? 
MASKING                         ? 3  ? ? ? ? ? 
'CTF CORRECTION'                ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'            ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'          ? 6  ? ? ? ? ? 
'MODEL FITTING'                 ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'              ? 8  ? ? ? ? ? 
OTHER                           ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT'      ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'        ? 11 1 ? ? ? ? 
CLASSIFICATION                  ? 12 1 ? ? ? ? 
RECONSTRUCTION                  ? 13 1 ? ? ? ? 
'VOLUME SELECTION'              ? 14 1 1 1 ? ? 
'SERIES ALIGNMENT'              ? 15 1 1 1 ? ? 
'MOLECULAR REPLACEMENT'         ? 16 1 1 1 ? ? 
'LATTICE DISTORTION CORRECTION' ? 17 1 1 1 ? ? 
'SYMMETRY DETERMINATION'        ? 18 1 1 1 ? ? 
'CRYSTALLOGRAPHY MERGING'       ? 19 1 1 1 ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)' 'United States' R35GM140892 1 
'Welch Foundation'                                                                         'United States' I-1578      2 
'Howard Hughes Medical Institute (HHMI)'                                                   'United States' ?           3 
# 
_atom_sites.entry_id                    9IV8 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C  
CA 
N  
O  
P  
S  
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . SER A 1 52  ? 177.189 151.762 132.594 1.00 92.82  ? 17   SER A N   1 
ATOM   2    C  CA  . SER A 1 52  ? 177.943 152.260 131.451 1.00 92.82  ? 17   SER A CA  1 
ATOM   3    C  C   . SER A 1 52  ? 177.996 153.782 131.456 1.00 92.82  ? 17   SER A C   1 
ATOM   4    O  O   . SER A 1 52  ? 177.530 154.425 132.396 1.00 92.82  ? 17   SER A O   1 
ATOM   5    C  CB  . SER A 1 52  ? 177.330 151.763 130.142 1.00 92.82  ? 17   SER A CB  1 
ATOM   6    O  OG  . SER A 1 52  ? 176.135 152.462 129.841 1.00 92.82  ? 17   SER A OG  1 
ATOM   7    N  N   . TYR A 1 53  ? 178.569 154.354 130.398 1.00 89.07  ? 18   TYR A N   1 
ATOM   8    C  CA  . TYR A 1 53  ? 178.687 155.800 130.266 1.00 89.07  ? 18   TYR A CA  1 
ATOM   9    C  C   . TYR A 1 53  ? 177.896 156.350 129.086 1.00 89.07  ? 18   TYR A C   1 
ATOM   10   O  O   . TYR A 1 53  ? 177.980 157.551 128.804 1.00 89.07  ? 18   TYR A O   1 
ATOM   11   C  CB  . TYR A 1 53  ? 180.160 156.204 130.159 1.00 89.07  ? 18   TYR A CB  1 
ATOM   12   C  CG  . TYR A 1 53  ? 180.995 155.710 131.317 1.00 89.07  ? 18   TYR A CG  1 
ATOM   13   C  CD1 . TYR A 1 53  ? 180.944 156.343 132.552 1.00 89.07  ? 18   TYR A CD1 1 
ATOM   14   C  CD2 . TYR A 1 53  ? 181.824 154.604 131.181 1.00 89.07  ? 18   TYR A CD2 1 
ATOM   15   C  CE1 . TYR A 1 53  ? 181.700 155.895 133.617 1.00 89.07  ? 18   TYR A CE1 1 
ATOM   16   C  CE2 . TYR A 1 53  ? 182.585 154.148 132.241 1.00 89.07  ? 18   TYR A CE2 1 
ATOM   17   C  CZ  . TYR A 1 53  ? 182.519 154.797 133.456 1.00 89.07  ? 18   TYR A CZ  1 
ATOM   18   O  OH  . TYR A 1 53  ? 183.274 154.347 134.514 1.00 89.07  ? 18   TYR A OH  1 
ATOM   19   N  N   . TYR A 1 54  ? 177.135 155.511 128.392 1.00 91.62  ? 19   TYR A N   1 
ATOM   20   C  CA  . TYR A 1 54  ? 176.185 155.970 127.389 1.00 91.62  ? 19   TYR A CA  1 
ATOM   21   C  C   . TYR A 1 54  ? 174.793 155.930 128.004 1.00 91.62  ? 19   TYR A C   1 
ATOM   22   O  O   . TYR A 1 54  ? 174.417 154.940 128.641 1.00 91.62  ? 19   TYR A O   1 
ATOM   23   C  CB  . TYR A 1 54  ? 176.258 155.120 126.114 1.00 91.62  ? 19   TYR A CB  1 
ATOM   24   C  CG  . TYR A 1 54  ? 175.796 153.682 126.251 1.00 91.62  ? 19   TYR A CG  1 
ATOM   25   C  CD1 . TYR A 1 54  ? 176.681 152.682 126.632 1.00 91.62  ? 19   TYR A CD1 1 
ATOM   26   C  CD2 . TYR A 1 54  ? 174.485 153.319 125.957 1.00 91.62  ? 19   TYR A CD2 1 
ATOM   27   C  CE1 . TYR A 1 54  ? 176.267 151.367 126.749 1.00 91.62  ? 19   TYR A CE1 1 
ATOM   28   C  CE2 . TYR A 1 54  ? 174.063 152.008 126.073 1.00 91.62  ? 19   TYR A CE2 1 
ATOM   29   C  CZ  . TYR A 1 54  ? 174.958 151.036 126.467 1.00 91.62  ? 19   TYR A CZ  1 
ATOM   30   O  OH  . TYR A 1 54  ? 174.543 149.729 126.579 1.00 91.62  ? 19   TYR A OH  1 
ATOM   31   N  N   . CYS A 1 55  ? 174.046 157.016 127.844 1.00 75.42  ? 20   CYS A N   1 
ATOM   32   C  CA  . CYS A 1 55  ? 172.758 157.181 128.505 1.00 75.42  ? 20   CYS A CA  1 
ATOM   33   C  C   . CYS A 1 55  ? 171.641 157.063 127.480 1.00 75.42  ? 20   CYS A C   1 
ATOM   34   O  O   . CYS A 1 55  ? 171.591 157.836 126.517 1.00 75.42  ? 20   CYS A O   1 
ATOM   35   C  CB  . CYS A 1 55  ? 172.686 158.525 129.227 1.00 75.42  ? 20   CYS A CB  1 
ATOM   36   S  SG  . CYS A 1 55  ? 174.223 159.007 130.036 1.00 75.42  ? 20   CYS A SG  1 
ATOM   37   N  N   . LYS A 1 56  ? 170.754 156.095 127.692 1.00 60.63  ? 21   LYS A N   1 
ATOM   38   C  CA  . LYS A 1 56  ? 169.535 155.999 126.904 1.00 60.63  ? 21   LYS A CA  1 
ATOM   39   C  C   . LYS A 1 56  ? 168.643 157.204 127.175 1.00 60.63  ? 21   LYS A C   1 
ATOM   40   O  O   . LYS A 1 56  ? 168.658 157.780 128.267 1.00 60.63  ? 21   LYS A O   1 
ATOM   41   C  CB  . LYS A 1 56  ? 168.803 154.699 127.234 1.00 60.63  ? 21   LYS A CB  1 
ATOM   42   C  CG  . LYS A 1 56  ? 168.530 154.520 128.719 1.00 60.63  ? 21   LYS A CG  1 
ATOM   43   C  CD  . LYS A 1 56  ? 168.084 153.104 129.043 1.00 60.63  ? 21   LYS A CD  1 
ATOM   44   C  CE  . LYS A 1 56  ? 167.340 153.049 130.366 1.00 60.63  ? 21   LYS A CE  1 
ATOM   45   N  NZ  . LYS A 1 56  ? 166.210 152.080 130.336 1.00 60.63  ? 21   LYS A NZ  1 
ATOM   46   N  N   . LYS A 1 57  ? 167.882 157.601 126.157 1.00 54.12  ? 22   LYS A N   1 
ATOM   47   C  CA  . LYS A 1 57  ? 167.040 158.783 126.276 1.00 54.12  ? 22   LYS A CA  1 
ATOM   48   C  C   . LYS A 1 57  ? 165.970 158.574 127.341 1.00 54.12  ? 22   LYS A C   1 
ATOM   49   O  O   . LYS A 1 57  ? 165.477 157.461 127.547 1.00 54.12  ? 22   LYS A O   1 
ATOM   50   C  CB  . LYS A 1 57  ? 166.408 159.130 124.921 1.00 54.12  ? 22   LYS A CB  1 
ATOM   51   C  CG  . LYS A 1 57  ? 165.013 158.582 124.659 1.00 54.12  ? 22   LYS A CG  1 
ATOM   52   C  CD  . LYS A 1 57  ? 164.628 158.755 123.197 1.00 54.12  ? 22   LYS A CD  1 
ATOM   53   C  CE  . LYS A 1 57  ? 164.643 160.220 122.787 1.00 54.12  ? 22   LYS A CE  1 
ATOM   54   N  NZ  . LYS A 1 57  ? 163.592 161.011 123.483 1.00 54.12  ? 22   LYS A NZ  1 
ATOM   55   N  N   . GLY A 1 58  ? 165.657 159.645 128.062 1.00 45.40  ? 23   GLY A N   1 
ATOM   56   C  CA  . GLY A 1 58  ? 164.649 159.592 129.094 1.00 45.40  ? 23   GLY A CA  1 
ATOM   57   C  C   . GLY A 1 58  ? 163.246 159.673 128.529 1.00 45.40  ? 23   GLY A C   1 
ATOM   58   O  O   . GLY A 1 58  ? 163.025 159.822 127.328 1.00 45.40  ? 23   GLY A O   1 
ATOM   59   N  N   . VAL A 1 59  ? 162.274 159.557 129.433 1.00 40.11  ? 24   VAL A N   1 
ATOM   60   C  CA  . VAL A 1 59  ? 160.880 159.726 129.042 1.00 40.11  ? 24   VAL A CA  1 
ATOM   61   C  C   . VAL A 1 59  ? 160.614 161.175 128.653 1.00 40.11  ? 24   VAL A C   1 
ATOM   62   O  O   . VAL A 1 59  ? 159.875 161.454 127.701 1.00 40.11  ? 24   VAL A O   1 
ATOM   63   C  CB  . VAL A 1 59  ? 159.953 159.255 130.177 1.00 40.11  ? 24   VAL A CB  1 
ATOM   64   C  CG1 . VAL A 1 59  ? 158.494 159.461 129.806 1.00 40.11  ? 24   VAL A CG1 1 
ATOM   65   C  CG2 . VAL A 1 59  ? 160.224 157.797 130.500 1.00 40.11  ? 24   VAL A CG2 1 
ATOM   66   N  N   . ILE A 1 60  ? 161.228 162.119 129.367 1.00 42.92  ? 25   ILE A N   1 
ATOM   67   C  CA  . ILE A 1 60  ? 161.032 163.540 129.104 1.00 42.92  ? 25   ILE A CA  1 
ATOM   68   C  C   . ILE A 1 60  ? 162.350 164.185 128.693 1.00 42.92  ? 25   ILE A C   1 
ATOM   69   O  O   . ILE A 1 60  ? 162.457 164.768 127.609 1.00 42.92  ? 25   ILE A O   1 
ATOM   70   C  CB  . ILE A 1 60  ? 160.434 164.249 130.333 1.00 42.92  ? 25   ILE A CB  1 
ATOM   71   C  CG1 . ILE A 1 60  ? 158.985 163.808 130.548 1.00 42.92  ? 25   ILE A CG1 1 
ATOM   72   C  CG2 . ILE A 1 60  ? 160.525 165.761 130.178 1.00 42.92  ? 25   ILE A CG2 1 
ATOM   73   C  CD1 . ILE A 1 60  ? 158.005 164.393 129.557 1.00 42.92  ? 25   ILE A CD1 1 
ATOM   74   N  N   . LEU A 1 61  ? 163.356 164.086 129.552 1.00 49.18  ? 26   LEU A N   1 
ATOM   75   C  CA  . LEU A 1 61  ? 164.610 164.803 129.342 1.00 49.18  ? 26   LEU A CA  1 
ATOM   76   C  C   . LEU A 1 61  ? 165.456 164.105 128.282 1.00 49.18  ? 26   LEU A C   1 
ATOM   77   O  O   . LEU A 1 61  ? 165.583 162.877 128.310 1.00 49.18  ? 26   LEU A O   1 
ATOM   78   C  CB  . LEU A 1 61  ? 165.389 164.898 130.646 1.00 49.18  ? 26   LEU A CB  1 
ATOM   79   C  CG  . LEU A 1 61  ? 164.674 165.617 131.787 1.00 49.18  ? 26   LEU A CG  1 
ATOM   80   C  CD1 . LEU A 1 61  ? 165.517 165.575 133.046 1.00 49.18  ? 26   LEU A CD1 1 
ATOM   81   C  CD2 . LEU A 1 61  ? 164.360 167.044 131.392 1.00 49.18  ? 26   LEU A CD2 1 
ATOM   82   N  N   . PRO A 1 62  ? 166.042 164.841 127.344 1.00 52.62  ? 27   PRO A N   1 
ATOM   83   C  CA  . PRO A 1 62  ? 166.968 164.240 126.384 1.00 52.62  ? 27   PRO A CA  1 
ATOM   84   C  C   . PRO A 1 62  ? 168.383 164.154 126.948 1.00 52.62  ? 27   PRO A C   1 
ATOM   85   O  O   . PRO A 1 62  ? 168.705 164.717 127.996 1.00 52.62  ? 27   PRO A O   1 
ATOM   86   C  CB  . PRO A 1 62  ? 166.911 165.207 125.195 1.00 52.62  ? 27   PRO A CB  1 
ATOM   87   C  CG  . PRO A 1 62  ? 166.603 166.519 125.811 1.00 52.62  ? 27   PRO A CG  1 
ATOM   88   C  CD  . PRO A 1 62  ? 165.734 166.244 127.012 1.00 52.62  ? 27   PRO A CD  1 
ATOM   89   N  N   . ILE A 1 63  ? 169.228 163.424 126.217 1.00 66.67  ? 28   ILE A N   1 
ATOM   90   C  CA  . ILE A 1 63  ? 170.588 163.151 126.662 1.00 66.67  ? 28   ILE A CA  1 
ATOM   91   C  C   . ILE A 1 63  ? 171.414 164.428 126.564 1.00 66.67  ? 28   ILE A C   1 
ATOM   92   O  O   . ILE A 1 63  ? 171.219 165.257 125.665 1.00 66.67  ? 28   ILE A O   1 
ATOM   93   C  CB  . ILE A 1 63  ? 171.258 162.021 125.849 1.00 66.67  ? 28   ILE A CB  1 
ATOM   94   C  CG1 . ILE A 1 63  ? 170.328 160.829 125.557 1.00 66.67  ? 28   ILE A CG1 1 
ATOM   95   C  CG2 . ILE A 1 63  ? 172.510 161.501 126.552 1.00 66.67  ? 28   ILE A CG2 1 
ATOM   96   C  CD1 . ILE A 1 63  ? 169.433 160.970 124.316 1.00 66.67  ? 28   ILE A CD1 1 
ATOM   97   N  N   . TRP A 1 64  ? 172.347 164.593 127.499 1.00 79.24  ? 29   TRP A N   1 
ATOM   98   C  CA  . TRP A 1 64  ? 173.374 165.611 127.342 1.00 79.24  ? 29   TRP A CA  1 
ATOM   99   C  C   . TRP A 1 64  ? 174.236 165.215 126.147 1.00 79.24  ? 29   TRP A C   1 
ATOM   100  O  O   . TRP A 1 64  ? 174.777 164.104 126.108 1.00 79.24  ? 29   TRP A O   1 
ATOM   101  C  CB  . TRP A 1 64  ? 174.228 165.705 128.604 1.00 79.24  ? 29   TRP A CB  1 
ATOM   102  C  CG  . TRP A 1 64  ? 174.765 167.073 128.905 1.00 79.24  ? 29   TRP A CG  1 
ATOM   103  C  CD1 . TRP A 1 64  ? 175.960 167.595 128.512 1.00 79.24  ? 29   TRP A CD1 1 
ATOM   104  C  CD2 . TRP A 1 64  ? 174.166 168.048 129.766 1.00 79.24  ? 29   TRP A CD2 1 
ATOM   105  N  NE1 . TRP A 1 64  ? 176.114 168.862 129.025 1.00 79.24  ? 29   TRP A NE1 1 
ATOM   106  C  CE2 . TRP A 1 64  ? 175.027 169.160 129.804 1.00 79.24  ? 29   TRP A CE2 1 
ATOM   107  C  CE3 . TRP A 1 64  ? 172.970 168.098 130.486 1.00 79.24  ? 29   TRP A CE3 1 
ATOM   108  C  CZ2 . TRP A 1 64  ? 174.731 170.307 130.539 1.00 79.24  ? 29   TRP A CZ2 1 
ATOM   109  C  CZ3 . TRP A 1 64  ? 172.677 169.235 131.212 1.00 79.24  ? 29   TRP A CZ3 1 
ATOM   110  C  CH2 . TRP A 1 64  ? 173.552 170.323 131.233 1.00 79.24  ? 29   TRP A CH2 1 
ATOM   111  N  N   . GLU A 1 65  ? 174.336 166.109 125.157 1.00 86.69  ? 30   GLU A N   1 
ATOM   112  C  CA  . GLU A 1 65  ? 174.899 165.712 123.865 1.00 86.69  ? 30   GLU A CA  1 
ATOM   113  C  C   . GLU A 1 65  ? 176.370 165.313 123.942 1.00 86.69  ? 30   GLU A C   1 
ATOM   114  O  O   . GLU A 1 65  ? 176.730 164.283 123.343 1.00 86.69  ? 30   GLU A O   1 
ATOM   115  C  CB  . GLU A 1 65  ? 174.630 166.801 122.813 1.00 86.69  ? 30   GLU A CB  1 
ATOM   116  C  CG  . GLU A 1 65  ? 173.148 167.036 122.415 1.00 86.69  ? 30   GLU A CG  1 
ATOM   117  C  CD  . GLU A 1 65  ? 172.389 165.827 121.811 1.00 86.69  ? 30   GLU A CD  1 
ATOM   118  O  OE1 . GLU A 1 65  ? 172.835 164.660 121.872 1.00 86.69  ? 30   GLU A OE1 1 
ATOM   119  O  OE2 . GLU A 1 65  ? 171.298 166.065 121.251 1.00 86.69  ? 30   GLU A OE2 1 
ATOM   120  N  N   . PRO A 1 66  ? 177.263 166.033 124.633 1.00 85.77  ? 31   PRO A N   1 
ATOM   121  C  CA  . PRO A 1 66  ? 178.601 165.473 124.860 1.00 85.77  ? 31   PRO A CA  1 
ATOM   122  C  C   . PRO A 1 66  ? 178.554 164.305 125.834 1.00 85.77  ? 31   PRO A C   1 
ATOM   123  O  O   . PRO A 1 66  ? 177.941 164.386 126.901 1.00 85.77  ? 31   PRO A O   1 
ATOM   124  C  CB  . PRO A 1 66  ? 179.382 166.650 125.451 1.00 85.77  ? 31   PRO A CB  1 
ATOM   125  C  CG  . PRO A 1 66  ? 178.711 167.840 124.918 1.00 85.77  ? 31   PRO A CG  1 
ATOM   126  C  CD  . PRO A 1 66  ? 177.254 167.484 124.919 1.00 85.77  ? 31   PRO A CD  1 
ATOM   127  N  N   . GLN A 1 67  ? 179.231 163.220 125.468 1.00 91.98  ? 32   GLN A N   1 
ATOM   128  C  CA  . GLN A 1 67  ? 179.255 162.006 126.267 1.00 91.98  ? 32   GLN A CA  1 
ATOM   129  C  C   . GLN A 1 67  ? 180.693 161.679 126.640 1.00 91.98  ? 32   GLN A C   1 
ATOM   130  O  O   . GLN A 1 67  ? 181.585 161.728 125.789 1.00 91.98  ? 32   GLN A O   1 
ATOM   131  C  CB  . GLN A 1 67  ? 178.630 160.840 125.503 1.00 91.98  ? 32   GLN A CB  1 
ATOM   132  C  CG  . GLN A 1 67  ? 177.211 161.113 125.036 1.00 91.98  ? 32   GLN A CG  1 
ATOM   133  C  CD  . GLN A 1 67  ? 176.384 159.855 124.892 1.00 91.98  ? 32   GLN A CD  1 
ATOM   134  O  OE1 . GLN A 1 67  ? 176.906 158.744 124.950 1.00 91.98  ? 32   GLN A OE1 1 
ATOM   135  N  NE2 . GLN A 1 67  ? 175.083 160.026 124.685 1.00 91.98  ? 32   GLN A NE2 1 
ATOM   136  N  N   . ASP A 1 68  ? 180.899 161.307 127.905 1.00 94.01  ? 33   ASP A N   1 
ATOM   137  C  CA  . ASP A 1 68  ? 182.211 161.118 128.519 1.00 94.01  ? 33   ASP A CA  1 
ATOM   138  C  C   . ASP A 1 68  ? 183.142 162.294 128.195 1.00 94.01  ? 33   ASP A C   1 
ATOM   139  O  O   . ASP A 1 68  ? 184.171 162.110 127.539 1.00 94.01  ? 33   ASP A O   1 
ATOM   140  C  CB  . ASP A 1 68  ? 182.833 159.794 128.084 1.00 94.01  ? 33   ASP A CB  1 
ATOM   141  C  CG  . ASP A 1 68  ? 183.836 159.251 129.091 1.00 94.01  ? 33   ASP A CG  1 
ATOM   142  O  OD1 . ASP A 1 68  ? 184.544 160.056 129.733 1.00 94.01  ? 33   ASP A OD1 1 
ATOM   143  O  OD2 . ASP A 1 68  ? 183.917 158.013 129.237 1.00 94.01  ? 33   ASP A OD2 1 
ATOM   144  N  N   . PRO A 1 69  ? 182.798 163.521 128.627 1.00 92.38  ? 34   PRO A N   1 
ATOM   145  C  CA  . PRO A 1 69  ? 183.580 164.687 128.195 1.00 92.38  ? 34   PRO A CA  1 
ATOM   146  C  C   . PRO A 1 69  ? 184.947 164.798 128.857 1.00 92.38  ? 34   PRO A C   1 
ATOM   147  O  O   . PRO A 1 69  ? 185.951 165.018 128.171 1.00 92.38  ? 34   PRO A O   1 
ATOM   148  C  CB  . PRO A 1 69  ? 182.672 165.864 128.574 1.00 92.38  ? 34   PRO A CB  1 
ATOM   149  C  CG  . PRO A 1 69  ? 181.934 165.379 129.767 1.00 92.38  ? 34   PRO A CG  1 
ATOM   150  C  CD  . PRO A 1 69  ? 181.696 163.909 129.531 1.00 92.38  ? 34   PRO A CD  1 
ATOM   151  N  N   . SER A 1 70  ? 185.000 164.624 130.175 1.00 90.04  ? 35   SER A N   1 
ATOM   152  C  CA  . SER A 1 70  ? 186.204 164.848 130.964 1.00 90.04  ? 35   SER A CA  1 
ATOM   153  C  C   . SER A 1 70  ? 185.949 164.350 132.377 1.00 90.04  ? 35   SER A C   1 
ATOM   154  O  O   . SER A 1 70  ? 184.807 164.091 132.764 1.00 90.04  ? 35   SER A O   1 
ATOM   155  C  CB  . SER A 1 70  ? 186.602 166.328 130.988 1.00 90.04  ? 35   SER A CB  1 
ATOM   156  O  OG  . SER A 1 70  ? 187.587 166.573 131.974 1.00 90.04  ? 35   SER A OG  1 
ATOM   157  N  N   . PHE A 1 71  ? 187.035 164.210 133.139 1.00 92.79  ? 36   PHE A N   1 
ATOM   158  C  CA  . PHE A 1 71  ? 186.909 163.818 134.539 1.00 92.79  ? 36   PHE A CA  1 
ATOM   159  C  C   . PHE A 1 71  ? 186.248 164.917 135.363 1.00 92.79  ? 36   PHE A C   1 
ATOM   160  O  O   . PHE A 1 71  ? 185.487 164.631 136.294 1.00 92.79  ? 36   PHE A O   1 
ATOM   161  C  CB  . PHE A 1 71  ? 188.281 163.466 135.113 1.00 92.79  ? 36   PHE A CB  1 
ATOM   162  C  CG  . PHE A 1 71  ? 188.966 162.335 134.399 1.00 92.79  ? 36   PHE A CG  1 
ATOM   163  C  CD1 . PHE A 1 71  ? 188.612 161.020 134.652 1.00 92.79  ? 36   PHE A CD1 1 
ATOM   164  C  CD2 . PHE A 1 71  ? 189.969 162.589 133.476 1.00 92.79  ? 36   PHE A CD2 1 
ATOM   165  C  CE1 . PHE A 1 71  ? 189.243 159.978 133.995 1.00 92.79  ? 36   PHE A CE1 1 
ATOM   166  C  CE2 . PHE A 1 71  ? 190.603 161.553 132.816 1.00 92.79  ? 36   PHE A CE2 1 
ATOM   167  C  CZ  . PHE A 1 71  ? 190.240 160.245 133.076 1.00 92.79  ? 36   PHE A CZ  1 
ATOM   168  N  N   . GLY A 1 72  ? 186.532 166.181 135.039 1.00 85.28  ? 37   GLY A N   1 
ATOM   169  C  CA  . GLY A 1 72  ? 185.982 167.281 135.812 1.00 85.28  ? 37   GLY A CA  1 
ATOM   170  C  C   . GLY A 1 72  ? 184.593 167.712 135.393 1.00 85.28  ? 37   GLY A C   1 
ATOM   171  O  O   . GLY A 1 72  ? 183.809 168.168 136.232 1.00 85.28  ? 37   GLY A O   1 
ATOM   172  N  N   . ASP A 1 73  ? 184.265 167.584 134.104 1.00 80.71  ? 38   ASP A N   1 
ATOM   173  C  CA  . ASP A 1 73  ? 182.954 168.014 133.623 1.00 80.71  ? 38   ASP A CA  1 
ATOM   174  C  C   . ASP A 1 73  ? 181.847 167.091 134.121 1.00 80.71  ? 38   ASP A C   1 
ATOM   175  O  O   . ASP A 1 73  ? 180.680 167.507 134.213 1.00 80.71  ? 38   ASP A O   1 
ATOM   176  C  CB  . ASP A 1 73  ? 182.962 168.073 132.096 1.00 80.71  ? 38   ASP A CB  1 
ATOM   177  C  CG  . ASP A 1 73  ? 181.872 168.964 131.538 1.00 80.71  ? 38   ASP A CG  1 
ATOM   178  O  OD1 . ASP A 1 73  ? 181.134 169.580 132.334 1.00 80.71  ? 38   ASP A OD1 1 
ATOM   179  O  OD2 . ASP A 1 73  ? 181.754 169.051 130.297 1.00 80.71  ? 38   ASP A OD2 1 
ATOM   180  N  N   . LYS A 1 74  ? 182.197 165.841 134.443 1.00 72.08  ? 39   LYS A N   1 
ATOM   181  C  CA  . LYS A 1 74  ? 181.241 164.923 135.052 1.00 72.08  ? 39   LYS A CA  1 
ATOM   182  C  C   . LYS A 1 74  ? 180.688 165.489 136.350 1.00 72.08  ? 39   LYS A C   1 
ATOM   183  O  O   . LYS A 1 74  ? 179.505 165.316 136.650 1.00 72.08  ? 39   LYS A O   1 
ATOM   184  C  CB  . LYS A 1 74  ? 181.895 163.565 135.306 1.00 72.08  ? 39   LYS A CB  1 
ATOM   185  C  CG  . LYS A 1 74  ? 181.911 162.635 134.109 1.00 72.08  ? 39   LYS A CG  1 
ATOM   186  C  CD  . LYS A 1 74  ? 182.798 161.429 134.370 1.00 72.08  ? 39   LYS A CD  1 
ATOM   187  C  CE  . LYS A 1 74  ? 182.521 160.317 133.374 1.00 72.08  ? 39   LYS A CE  1 
ATOM   188  N  NZ  . LYS A 1 74  ? 182.212 160.848 132.019 1.00 72.08  ? 39   LYS A NZ  1 
ATOM   189  N  N   . ILE A 1 75  ? 181.528 166.172 137.130 1.00 69.90  ? 40   ILE A N   1 
ATOM   190  C  CA  . ILE A 1 75  ? 181.047 166.851 138.331 1.00 69.90  ? 40   ILE A CA  1 
ATOM   191  C  C   . ILE A 1 75  ? 180.074 167.963 137.960 1.00 69.90  ? 40   ILE A C   1 
ATOM   192  O  O   . ILE A 1 75  ? 179.009 168.109 138.576 1.00 69.90  ? 40   ILE A O   1 
ATOM   193  C  CB  . ILE A 1 75  ? 182.237 167.383 139.153 1.00 69.90  ? 40   ILE A CB  1 
ATOM   194  C  CG1 . ILE A 1 75  ? 182.938 166.233 139.875 1.00 69.90  ? 40   ILE A CG1 1 
ATOM   195  C  CG2 . ILE A 1 75  ? 181.782 168.433 140.155 1.00 69.90  ? 40   ILE A CG2 1 
ATOM   196  C  CD1 . ILE A 1 75  ? 182.030 165.452 140.793 1.00 69.90  ? 40   ILE A CD1 1 
ATOM   197  N  N   . ALA A 1 76  ? 180.412 168.747 136.931 1.00 69.01  ? 41   ALA A N   1 
ATOM   198  C  CA  . ALA A 1 76  ? 179.571 169.870 136.524 1.00 69.01  ? 41   ALA A CA  1 
ATOM   199  C  C   . ALA A 1 76  ? 178.194 169.417 136.056 1.00 69.01  ? 41   ALA A C   1 
ATOM   200  O  O   . ALA A 1 76  ? 177.223 170.173 136.171 1.00 69.01  ? 41   ALA A O   1 
ATOM   201  C  CB  . ALA A 1 76  ? 180.264 170.673 135.423 1.00 69.01  ? 41   ALA A CB  1 
ATOM   202  N  N   . ARG A 1 77  ? 178.082 168.202 135.522 1.00 70.99  ? 42   ARG A N   1 
ATOM   203  C  CA  . ARG A 1 77  ? 176.755 167.701 135.172 1.00 70.99  ? 42   ARG A CA  1 
ATOM   204  C  C   . ARG A 1 77  ? 176.082 166.949 136.318 1.00 70.99  ? 42   ARG A C   1 
ATOM   205  O  O   . ARG A 1 77  ? 174.863 167.064 136.510 1.00 70.99  ? 42   ARG A O   1 
ATOM   206  C  CB  . ARG A 1 77  ? 176.842 166.799 133.942 1.00 70.99  ? 42   ARG A CB  1 
ATOM   207  C  CG  . ARG A 1 77  ? 176.486 167.505 132.658 1.00 70.99  ? 42   ARG A CG  1 
ATOM   208  C  CD  . ARG A 1 77  ? 177.388 167.074 131.522 1.00 70.99  ? 42   ARG A CD  1 
ATOM   209  N  NE  . ARG A 1 77  ? 177.509 165.626 131.427 1.00 70.99  ? 42   ARG A NE  1 
ATOM   210  C  CZ  . ARG A 1 77  ? 178.153 164.992 130.457 1.00 70.99  ? 42   ARG A CZ  1 
ATOM   211  N  NH1 . ARG A 1 77  ? 178.689 165.647 129.441 1.00 70.99  ? 42   ARG A NH1 1 
ATOM   212  N  NH2 . ARG A 1 77  ? 178.248 163.665 130.499 1.00 70.99  ? 42   ARG A NH2 1 
ATOM   213  N  N   . ALA A 1 78  ? 176.856 166.193 137.099 1.00 54.37  ? 43   ALA A N   1 
ATOM   214  C  CA  . ALA A 1 78  ? 176.278 165.343 138.128 1.00 54.37  ? 43   ALA A CA  1 
ATOM   215  C  C   . ALA A 1 78  ? 175.773 166.146 139.313 1.00 54.37  ? 43   ALA A C   1 
ATOM   216  O  O   . ALA A 1 78  ? 174.767 165.768 139.920 1.00 54.37  ? 43   ALA A O   1 
ATOM   217  C  CB  . ALA A 1 78  ? 177.302 164.311 138.593 1.00 54.37  ? 43   ALA A CB  1 
ATOM   218  N  N   . THR A 1 79  ? 176.448 167.242 139.670 1.00 49.59  ? 44   THR A N   1 
ATOM   219  C  CA  . THR A 1 79  ? 175.943 168.062 140.764 1.00 49.59  ? 44   THR A CA  1 
ATOM   220  C  C   . THR A 1 79  ? 174.628 168.730 140.377 1.00 49.59  ? 44   THR A C   1 
ATOM   221  O  O   . THR A 1 79  ? 173.720 168.841 141.208 1.00 49.59  ? 44   THR A O   1 
ATOM   222  C  CB  . THR A 1 79  ? 177.012 169.073 141.218 1.00 49.59  ? 44   THR A CB  1 
ATOM   223  O  OG1 . THR A 1 79  ? 176.802 169.413 142.595 1.00 49.59  ? 44   THR A OG1 1 
ATOM   224  C  CG2 . THR A 1 79  ? 177.039 170.346 140.376 1.00 49.59  ? 44   THR A CG2 1 
ATOM   225  N  N   . VAL A 1 80  ? 174.472 169.097 139.101 1.00 47.55  ? 45   VAL A N   1 
ATOM   226  C  CA  . VAL A 1 80  ? 173.213 169.669 138.635 1.00 47.55  ? 45   VAL A CA  1 
ATOM   227  C  C   . VAL A 1 80  ? 172.114 168.615 138.666 1.00 47.55  ? 45   VAL A C   1 
ATOM   228  O  O   . VAL A 1 80  ? 171.003 168.871 139.147 1.00 47.55  ? 45   VAL A O   1 
ATOM   229  C  CB  . VAL A 1 80  ? 173.386 170.273 137.229 1.00 47.55  ? 45   VAL A CB  1 
ATOM   230  C  CG1 . VAL A 1 80  ? 172.065 170.284 136.466 1.00 47.55  ? 45   VAL A CG1 1 
ATOM   231  C  CG2 . VAL A 1 80  ? 173.961 171.677 137.327 1.00 47.55  ? 45   VAL A CG2 1 
ATOM   232  N  N   . TYR A 1 81  ? 172.420 167.407 138.183 1.00 44.04  ? 46   TYR A N   1 
ATOM   233  C  CA  . TYR A 1 81  ? 171.429 166.333 138.176 1.00 44.04  ? 46   TYR A CA  1 
ATOM   234  C  C   . TYR A 1 81  ? 170.992 165.968 139.593 1.00 44.04  ? 46   TYR A C   1 
ATOM   235  O  O   . TYR A 1 81  ? 169.795 165.826 139.873 1.00 44.04  ? 46   TYR A O   1 
ATOM   236  C  CB  . TYR A 1 81  ? 171.995 165.111 137.454 1.00 44.04  ? 46   TYR A CB  1 
ATOM   237  C  CG  . TYR A 1 81  ? 171.663 165.061 135.981 1.00 44.04  ? 46   TYR A CG  1 
ATOM   238  C  CD1 . TYR A 1 81  ? 170.351 165.160 135.544 1.00 44.04  ? 46   TYR A CD1 1 
ATOM   239  C  CD2 . TYR A 1 81  ? 172.659 164.907 135.028 1.00 44.04  ? 46   TYR A CD2 1 
ATOM   240  C  CE1 . TYR A 1 81  ? 170.038 165.112 134.201 1.00 44.04  ? 46   TYR A CE1 1 
ATOM   241  C  CE2 . TYR A 1 81  ? 172.356 164.857 133.682 1.00 44.04  ? 46   TYR A CE2 1 
ATOM   242  C  CZ  . TYR A 1 81  ? 171.043 164.961 133.275 1.00 44.04  ? 46   TYR A CZ  1 
ATOM   243  O  OH  . TYR A 1 81  ? 170.732 164.913 131.937 1.00 44.04  ? 46   TYR A OH  1 
ATOM   244  N  N   . PHE A 1 82  ? 171.954 165.840 140.510 1.00 42.43  ? 47   PHE A N   1 
ATOM   245  C  CA  . PHE A 1 82  ? 171.642 165.430 141.876 1.00 42.43  ? 47   PHE A CA  1 
ATOM   246  C  C   . PHE A 1 82  ? 170.902 166.525 142.636 1.00 42.43  ? 47   PHE A C   1 
ATOM   247  O  O   . PHE A 1 82  ? 169.972 166.234 143.397 1.00 42.43  ? 47   PHE A O   1 
ATOM   248  C  CB  . PHE A 1 82  ? 172.929 165.039 142.600 1.00 42.43  ? 47   PHE A CB  1 
ATOM   249  C  CG  . PHE A 1 82  ? 172.720 164.584 144.012 1.00 42.43  ? 47   PHE A CG  1 
ATOM   250  C  CD1 . PHE A 1 82  ? 172.120 163.365 144.276 1.00 42.43  ? 47   PHE A CD1 1 
ATOM   251  C  CD2 . PHE A 1 82  ? 173.136 165.365 145.075 1.00 42.43  ? 47   PHE A CD2 1 
ATOM   252  C  CE1 . PHE A 1 82  ? 171.932 162.936 145.575 1.00 42.43  ? 47   PHE A CE1 1 
ATOM   253  C  CE2 . PHE A 1 82  ? 172.951 164.942 146.377 1.00 42.43  ? 47   PHE A CE2 1 
ATOM   254  C  CZ  . PHE A 1 82  ? 172.348 163.726 146.627 1.00 42.43  ? 47   PHE A CZ  1 
ATOM   255  N  N   . VAL A 1 83  ? 171.301 167.789 142.450 1.00 39.65  ? 48   VAL A N   1 
ATOM   256  C  CA  . VAL A 1 83  ? 170.590 168.897 143.080 1.00 39.65  ? 48   VAL A CA  1 
ATOM   257  C  C   . VAL A 1 83  ? 169.165 168.984 142.549 1.00 39.65  ? 48   VAL A C   1 
ATOM   258  O  O   . VAL A 1 83  ? 168.217 169.222 143.309 1.00 39.65  ? 48   VAL A O   1 
ATOM   259  C  CB  . VAL A 1 83  ? 171.370 170.209 142.870 1.00 39.65  ? 48   VAL A CB  1 
ATOM   260  C  CG1 . VAL A 1 83  ? 170.444 171.419 142.866 1.00 39.65  ? 48   VAL A CG1 1 
ATOM   261  C  CG2 . VAL A 1 83  ? 172.439 170.359 143.941 1.00 39.65  ? 48   VAL A CG2 1 
ATOM   262  N  N   . ALA A 1 84  ? 168.988 168.770 141.241 1.00 38.92  ? 49   ALA A N   1 
ATOM   263  C  CA  . ALA A 1 84  ? 167.649 168.761 140.667 1.00 38.92  ? 49   ALA A CA  1 
ATOM   264  C  C   . ALA A 1 84  ? 166.805 167.637 141.250 1.00 38.92  ? 49   ALA A C   1 
ATOM   265  O  O   . ALA A 1 84  ? 165.624 167.835 141.541 1.00 38.92  ? 49   ALA A O   1 
ATOM   266  C  CB  . ALA A 1 84  ? 167.727 168.640 139.147 1.00 38.92  ? 49   ALA A CB  1 
ATOM   267  N  N   . MET A 1 85  ? 167.396 166.456 141.448 1.00 32.85  ? 50   MET A N   1 
ATOM   268  C  CA  . MET A 1 85  ? 166.646 165.351 142.043 1.00 32.85  ? 50   MET A CA  1 
ATOM   269  C  C   . MET A 1 85  ? 166.256 165.646 143.491 1.00 32.85  ? 50   MET A C   1 
ATOM   270  O  O   . MET A 1 85  ? 165.120 165.370 143.905 1.00 32.85  ? 50   MET A O   1 
ATOM   271  C  CB  . MET A 1 85  ? 167.460 164.060 141.954 1.00 32.85  ? 50   MET A CB  1 
ATOM   272  C  CG  . MET A 1 85  ? 166.622 162.794 141.952 1.00 32.85  ? 50   MET A CG  1 
ATOM   273  S  SD  . MET A 1 85  ? 167.622 161.295 141.932 1.00 32.85  ? 50   MET A SD  1 
ATOM   274  C  CE  . MET A 1 85  ? 168.668 161.570 143.356 1.00 32.85  ? 50   MET A CE  1 
ATOM   275  N  N   . VAL A 1 86  ? 167.181 166.208 144.275 1.00 32.22  ? 51   VAL A N   1 
ATOM   276  C  CA  . VAL A 1 86  ? 166.892 166.504 145.677 1.00 32.22  ? 51   VAL A CA  1 
ATOM   277  C  C   . VAL A 1 86  ? 165.812 167.574 145.793 1.00 32.22  ? 51   VAL A C   1 
ATOM   278  O  O   . VAL A 1 86  ? 164.883 167.452 146.600 1.00 32.22  ? 51   VAL A O   1 
ATOM   279  C  CB  . VAL A 1 86  ? 168.179 166.910 146.417 1.00 32.22  ? 51   VAL A CB  1 
ATOM   280  C  CG1 . VAL A 1 86  ? 167.858 167.415 147.810 1.00 32.22  ? 51   VAL A CG1 1 
ATOM   281  C  CG2 . VAL A 1 86  ? 169.125 165.728 146.502 1.00 32.22  ? 51   VAL A CG2 1 
ATOM   282  N  N   . TYR A 1 87  ? 165.900 168.628 144.979 1.00 37.17  ? 52   TYR A N   1 
ATOM   283  C  CA  . TYR A 1 87  ? 164.863 169.653 144.967 1.00 37.17  ? 52   TYR A CA  1 
ATOM   284  C  C   . TYR A 1 87  ? 163.567 169.146 144.349 1.00 37.17  ? 52   TYR A C   1 
ATOM   285  O  O   . TYR A 1 87  ? 162.501 169.710 144.616 1.00 37.17  ? 52   TYR A O   1 
ATOM   286  C  CB  . TYR A 1 87  ? 165.379 170.884 144.218 1.00 37.17  ? 52   TYR A CB  1 
ATOM   287  C  CG  . TYR A 1 87  ? 164.428 172.056 144.148 1.00 37.17  ? 52   TYR A CG  1 
ATOM   288  C  CD1 . TYR A 1 87  ? 164.411 173.017 145.149 1.00 37.17  ? 52   TYR A CD1 1 
ATOM   289  C  CD2 . TYR A 1 87  ? 163.580 172.228 143.059 1.00 37.17  ? 52   TYR A CD2 1 
ATOM   290  C  CE1 . TYR A 1 87  ? 163.557 174.098 145.086 1.00 37.17  ? 52   TYR A CE1 1 
ATOM   291  C  CE2 . TYR A 1 87  ? 162.724 173.306 142.987 1.00 37.17  ? 52   TYR A CE2 1 
ATOM   292  C  CZ  . TYR A 1 87  ? 162.718 174.237 144.003 1.00 37.17  ? 52   TYR A CZ  1 
ATOM   293  O  OH  . TYR A 1 87  ? 161.868 175.312 143.933 1.00 37.17  ? 52   TYR A OH  1 
ATOM   294  N  N   . MET A 1 88  ? 163.635 168.094 143.536 1.00 29.55  ? 53   MET A N   1 
ATOM   295  C  CA  . MET A 1 88  ? 162.448 167.493 142.952 1.00 29.55  ? 53   MET A CA  1 
ATOM   296  C  C   . MET A 1 88  ? 161.693 166.648 143.967 1.00 29.55  ? 53   MET A C   1 
ATOM   297  O  O   . MET A 1 88  ? 160.464 166.543 143.890 1.00 29.55  ? 53   MET A O   1 
ATOM   298  C  CB  . MET A 1 88  ? 162.860 166.642 141.751 1.00 29.55  ? 53   MET A CB  1 
ATOM   299  C  CG  . MET A 1 88  ? 161.728 165.980 141.008 1.00 29.55  ? 53   MET A CG  1 
ATOM   300  S  SD  . MET A 1 88  ? 160.847 167.174 139.994 1.00 29.55  ? 53   MET A SD  1 
ATOM   301  C  CE  . MET A 1 88  ? 162.206 168.003 139.177 1.00 29.55  ? 53   MET A CE  1 
ATOM   302  N  N   . PHE A 1 89  ? 162.414 166.041 144.914 1.00 25.04  ? 54   PHE A N   1 
ATOM   303  C  CA  . PHE A 1 89  ? 161.761 165.224 145.935 1.00 25.04  ? 54   PHE A CA  1 
ATOM   304  C  C   . PHE A 1 89  ? 160.824 166.041 146.821 1.00 25.04  ? 54   PHE A C   1 
ATOM   305  O  O   . PHE A 1 89  ? 159.854 165.495 147.360 1.00 25.04  ? 54   PHE A O   1 
ATOM   306  C  CB  . PHE A 1 89  ? 162.800 164.517 146.803 1.00 25.04  ? 54   PHE A CB  1 
ATOM   307  C  CG  . PHE A 1 89  ? 163.414 163.315 146.155 1.00 25.04  ? 54   PHE A CG  1 
ATOM   308  C  CD1 . PHE A 1 89  ? 162.678 162.531 145.288 1.00 25.04  ? 54   PHE A CD1 1 
ATOM   309  C  CD2 . PHE A 1 89  ? 164.722 162.958 146.429 1.00 25.04  ? 54   PHE A CD2 1 
ATOM   310  C  CE1 . PHE A 1 89  ? 163.239 161.423 144.695 1.00 25.04  ? 54   PHE A CE1 1 
ATOM   311  C  CE2 . PHE A 1 89  ? 165.287 161.851 145.841 1.00 25.04  ? 54   PHE A CE2 1 
ATOM   312  C  CZ  . PHE A 1 89  ? 164.545 161.082 144.972 1.00 25.04  ? 54   PHE A CZ  1 
ATOM   313  N  N   . LEU A 1 90  ? 161.094 167.337 146.993 1.00 25.10  ? 55   LEU A N   1 
ATOM   314  C  CA  . LEU A 1 90  ? 160.217 168.171 147.812 1.00 25.10  ? 55   LEU A CA  1 
ATOM   315  C  C   . LEU A 1 90  ? 158.845 168.333 147.173 1.00 25.10  ? 55   LEU A C   1 
ATOM   316  O  O   . LEU A 1 90  ? 157.829 168.401 147.878 1.00 25.10  ? 55   LEU A O   1 
ATOM   317  C  CB  . LEU A 1 90  ? 160.854 169.538 148.048 1.00 25.10  ? 55   LEU A CB  1 
ATOM   318  C  CG  . LEU A 1 90  ? 162.065 169.602 148.976 1.00 25.10  ? 55   LEU A CG  1 
ATOM   319  C  CD1 . LEU A 1 90  ? 162.161 170.978 149.588 1.00 25.10  ? 55   LEU A CD1 1 
ATOM   320  C  CD2 . LEU A 1 90  ? 161.995 168.545 150.063 1.00 25.10  ? 55   LEU A CD2 1 
ATOM   321  N  N   . GLY A 1 91  ? 158.800 168.418 145.842 1.00 24.62  ? 56   GLY A N   1 
ATOM   322  C  CA  . GLY A 1 91  ? 157.520 168.481 145.159 1.00 24.62  ? 56   GLY A CA  1 
ATOM   323  C  C   . GLY A 1 91  ? 156.664 167.261 145.430 1.00 24.62  ? 56   GLY A C   1 
ATOM   324  O  O   . GLY A 1 91  ? 155.464 167.380 145.683 1.00 24.62  ? 56   GLY A O   1 
ATOM   325  N  N   . VAL A 1 92  ? 157.274 166.074 145.391 1.00 23.02  ? 57   VAL A N   1 
ATOM   326  C  CA  . VAL A 1 92  ? 156.564 164.852 145.756 1.00 23.02  ? 57   VAL A CA  1 
ATOM   327  C  C   . VAL A 1 92  ? 156.147 164.897 147.219 1.00 23.02  ? 57   VAL A C   1 
ATOM   328  O  O   . VAL A 1 92  ? 155.008 164.564 147.560 1.00 23.02  ? 57   VAL A O   1 
ATOM   329  C  CB  . VAL A 1 92  ? 157.433 163.618 145.446 1.00 23.02  ? 57   VAL A CB  1 
ATOM   330  C  CG1 . VAL A 1 92  ? 156.948 162.407 146.220 1.00 23.02  ? 57   VAL A CG1 1 
ATOM   331  C  CG2 . VAL A 1 92  ? 157.421 163.330 143.960 1.00 23.02  ? 57   VAL A CG2 1 
ATOM   332  N  N   . SER A 1 93  ? 157.048 165.344 148.100 1.00 23.75  ? 58   SER A N   1 
ATOM   333  C  CA  . SER A 1 93  ? 156.749 165.393 149.531 1.00 23.75  ? 58   SER A CA  1 
ATOM   334  C  C   . SER A 1 93  ? 155.563 166.298 149.848 1.00 23.75  ? 58   SER A C   1 
ATOM   335  O  O   . SER A 1 93  ? 154.854 166.064 150.832 1.00 23.75  ? 58   SER A O   1 
ATOM   336  C  CB  . SER A 1 93  ? 157.979 165.858 150.306 1.00 23.75  ? 58   SER A CB  1 
ATOM   337  O  OG  . SER A 1 93  ? 157.641 166.177 151.643 1.00 23.75  ? 58   SER A OG  1 
ATOM   338  N  N   . ILE A 1 94  ? 155.340 167.335 149.047 1.00 23.45  ? 59   ILE A N   1 
ATOM   339  C  CA  . ILE A 1 94  ? 154.212 168.239 149.280 1.00 23.45  ? 59   ILE A CA  1 
ATOM   340  C  C   . ILE A 1 94  ? 152.942 167.747 148.586 1.00 23.45  ? 59   ILE A C   1 
ATOM   341  O  O   . ILE A 1 94  ? 151.860 167.705 149.189 1.00 23.45  ? 59   ILE A O   1 
ATOM   342  C  CB  . ILE A 1 94  ? 154.584 169.668 148.835 1.00 23.45  ? 59   ILE A CB  1 
ATOM   343  C  CG1 . ILE A 1 94  ? 155.693 170.222 149.727 1.00 23.45  ? 59   ILE A CG1 1 
ATOM   344  C  CG2 . ILE A 1 94  ? 153.376 170.574 148.902 1.00 23.45  ? 59   ILE A CG2 1 
ATOM   345  C  CD1 . ILE A 1 94  ? 156.175 171.589 149.322 1.00 23.45  ? 59   ILE A CD1 1 
ATOM   346  N  N   . ILE A 1 95  ? 153.039 167.373 147.307 1.00 24.39  ? 60   ILE A N   1 
ATOM   347  C  CA  . ILE A 1 95  ? 151.834 166.996 146.576 1.00 24.39  ? 60   ILE A CA  1 
ATOM   348  C  C   . ILE A 1 95  ? 151.304 165.646 147.046 1.00 24.39  ? 60   ILE A C   1 
ATOM   349  O  O   . ILE A 1 95  ? 150.100 165.393 146.963 1.00 24.39  ? 60   ILE A O   1 
ATOM   350  C  CB  . ILE A 1 95  ? 152.084 167.024 145.056 1.00 24.39  ? 60   ILE A CB  1 
ATOM   351  C  CG1 . ILE A 1 95  ? 150.756 167.029 144.298 1.00 24.39  ? 60   ILE A CG1 1 
ATOM   352  C  CG2 . ILE A 1 95  ? 152.912 165.841 144.614 1.00 24.39  ? 60   ILE A CG2 1 
ATOM   353  C  CD1 . ILE A 1 95  ? 149.876 168.206 144.620 1.00 24.39  ? 60   ILE A CD1 1 
ATOM   354  N  N   . ALA A 1 96  ? 152.161 164.771 147.583 1.00 26.28  ? 61   ALA A N   1 
ATOM   355  C  CA  . ALA A 1 96  ? 151.663 163.532 148.166 1.00 26.28  ? 61   ALA A CA  1 
ATOM   356  C  C   . ALA A 1 96  ? 150.954 163.790 149.485 1.00 26.28  ? 61   ALA A C   1 
ATOM   357  O  O   . ALA A 1 96  ? 150.001 163.083 149.818 1.00 26.28  ? 61   ALA A O   1 
ATOM   358  C  CB  . ALA A 1 96  ? 152.807 162.540 148.361 1.00 26.28  ? 61   ALA A CB  1 
ATOM   359  N  N   . ASP A 1 97  ? 151.397 164.797 150.240 1.00 30.27  ? 62   ASP A N   1 
ATOM   360  C  CA  . ASP A 1 97  ? 150.664 165.216 151.430 1.00 30.27  ? 62   ASP A CA  1 
ATOM   361  C  C   . ASP A 1 97  ? 149.276 165.718 151.045 1.00 30.27  ? 62   ASP A C   1 
ATOM   362  O  O   . ASP A 1 97  ? 148.274 165.365 151.678 1.00 30.27  ? 62   ASP A O   1 
ATOM   363  C  CB  . ASP A 1 97  ? 151.467 166.297 152.163 1.00 30.27  ? 62   ASP A CB  1 
ATOM   364  C  CG  . ASP A 1 97  ? 150.736 166.900 153.361 1.00 30.27  ? 62   ASP A CG  1 
ATOM   365  O  OD1 . ASP A 1 97  ? 149.745 166.322 153.856 1.00 30.27  ? 62   ASP A OD1 1 
ATOM   366  O  OD2 . ASP A 1 97  ? 151.168 167.980 153.814 1.00 30.27  ? 62   ASP A OD2 1 
ATOM   367  N  N   . ARG A 1 98  ? 149.199 166.530 149.988 1.00 23.63  ? 63   ARG A N   1 
ATOM   368  C  CA  . ARG A 1 98  ? 147.894 167.019 149.541 1.00 23.63  ? 63   ARG A CA  1 
ATOM   369  C  C   . ARG A 1 98  ? 147.023 165.886 149.000 1.00 23.63  ? 63   ARG A C   1 
ATOM   370  O  O   . ARG A 1 98  ? 145.806 165.868 149.218 1.00 23.63  ? 63   ARG A O   1 
ATOM   371  C  CB  . ARG A 1 98  ? 148.071 168.114 148.492 1.00 23.63  ? 63   ARG A CB  1 
ATOM   372  C  CG  . ARG A 1 98  ? 146.787 168.840 148.146 1.00 23.63  ? 63   ARG A CG  1 
ATOM   373  C  CD  . ARG A 1 98  ? 147.061 170.295 147.823 1.00 23.63  ? 63   ARG A CD  1 
ATOM   374  N  NE  . ARG A 1 98  ? 147.827 170.942 148.880 1.00 23.63  ? 63   ARG A NE  1 
ATOM   375  C  CZ  . ARG A 1 98  ? 148.522 172.060 148.724 1.00 23.63  ? 63   ARG A CZ  1 
ATOM   376  N  NH1 . ARG A 1 98  ? 148.570 172.686 147.561 1.00 23.63  ? 63   ARG A NH1 1 
ATOM   377  N  NH2 . ARG A 1 98  ? 149.185 172.562 149.761 1.00 23.63  ? 63   ARG A NH2 1 
ATOM   378  N  N   . PHE A 1 99  ? 147.633 164.929 148.299 1.00 21.39  ? 64   PHE A N   1 
ATOM   379  C  CA  . PHE A 1 99  ? 146.916 163.760 147.799 1.00 21.39  ? 64   PHE A CA  1 
ATOM   380  C  C   . PHE A 1 99  ? 146.380 162.904 148.942 1.00 21.39  ? 64   PHE A C   1 
ATOM   381  O  O   . PHE A 1 99  ? 145.257 162.389 148.872 1.00 21.39  ? 64   PHE A O   1 
ATOM   382  C  CB  . PHE A 1 99  ? 147.856 162.955 146.905 1.00 21.39  ? 64   PHE A CB  1 
ATOM   383  C  CG  . PHE A 1 99  ? 147.248 161.723 146.319 1.00 21.39  ? 64   PHE A CG  1 
ATOM   384  C  CD1 . PHE A 1 99  ? 146.010 161.764 145.717 1.00 21.39  ? 64   PHE A CD1 1 
ATOM   385  C  CD2 . PHE A 1 99  ? 147.932 160.522 146.354 1.00 21.39  ? 64   PHE A CD2 1 
ATOM   386  C  CE1 . PHE A 1 99  ? 145.464 160.628 145.169 1.00 21.39  ? 64   PHE A CE1 1 
ATOM   387  C  CE2 . PHE A 1 99  ? 147.387 159.383 145.810 1.00 21.39  ? 64   PHE A CE2 1 
ATOM   388  C  CZ  . PHE A 1 99  ? 146.150 159.436 145.218 1.00 21.39  ? 64   PHE A CZ  1 
ATOM   389  N  N   . MET A 1 100 ? 147.176 162.744 150.000 1.00 28.91  ? 65   MET A N   1 
ATOM   390  C  CA  . MET A 1 100 ? 146.735 162.016 151.182 1.00 28.91  ? 65   MET A CA  1 
ATOM   391  C  C   . MET A 1 100 ? 145.597 162.744 151.884 1.00 28.91  ? 65   MET A C   1 
ATOM   392  O  O   . MET A 1 100 ? 144.663 162.110 152.385 1.00 28.91  ? 65   MET A O   1 
ATOM   393  C  CB  . MET A 1 100 ? 147.913 161.822 152.129 1.00 28.91  ? 65   MET A CB  1 
ATOM   394  C  CG  . MET A 1 100 ? 148.573 160.470 152.041 1.00 28.91  ? 65   MET A CG  1 
ATOM   395  S  SD  . MET A 1 100 ? 150.170 160.521 152.862 1.00 28.91  ? 65   MET A SD  1 
ATOM   396  C  CE  . MET A 1 100 ? 149.646 160.437 154.566 1.00 28.91  ? 65   MET A CE  1 
ATOM   397  N  N   . SER A 1 101 ? 145.662 164.076 151.933 1.00 33.18  ? 66   SER A N   1 
ATOM   398  C  CA  . SER A 1 101 ? 144.550 164.856 152.469 1.00 33.18  ? 66   SER A CA  1 
ATOM   399  C  C   . SER A 1 101 ? 143.281 164.640 151.653 1.00 33.18  ? 66   SER A C   1 
ATOM   400  O  O   . SER A 1 101 ? 142.188 164.476 152.214 1.00 33.18  ? 66   SER A O   1 
ATOM   401  C  CB  . SER A 1 101 ? 144.923 166.336 152.498 1.00 33.18  ? 66   SER A CB  1 
ATOM   402  O  OG  . SER A 1 101 ? 143.820 167.133 152.879 1.00 33.18  ? 66   SER A OG  1 
ATOM   403  N  N   . SER A 1 102 ? 143.408 164.620 150.325 1.00 31.25  ? 67   SER A N   1 
ATOM   404  C  CA  . SER A 1 102 ? 142.243 164.397 149.476 1.00 31.25  ? 67   SER A CA  1 
ATOM   405  C  C   . SER A 1 102 ? 141.654 163.007 149.683 1.00 31.25  ? 67   SER A C   1 
ATOM   406  O  O   . SER A 1 102 ? 140.430 162.857 149.775 1.00 31.25  ? 67   SER A O   1 
ATOM   407  C  CB  . SER A 1 102 ? 142.613 164.600 148.012 1.00 31.25  ? 67   SER A CB  1 
ATOM   408  O  OG  . SER A 1 102 ? 141.539 164.228 147.169 1.00 31.25  ? 67   SER A OG  1 
ATOM   409  N  N   . ILE A 1 103 ? 142.502 161.981 149.786 1.00 30.04  ? 68   ILE A N   1 
ATOM   410  C  CA  . ILE A 1 103 ? 141.978 160.628 149.963 1.00 30.04  ? 68   ILE A CA  1 
ATOM   411  C  C   . ILE A 1 103 ? 141.472 160.422 151.390 1.00 30.04  ? 68   ILE A C   1 
ATOM   412  O  O   . ILE A 1 103 ? 140.672 159.511 151.636 1.00 30.04  ? 68   ILE A O   1 
ATOM   413  C  CB  . ILE A 1 103 ? 143.037 159.582 149.566 1.00 30.04  ? 68   ILE A CB  1 
ATOM   414  C  CG1 . ILE A 1 103 ? 142.412 158.198 149.394 1.00 30.04  ? 68   ILE A CG1 1 
ATOM   415  C  CG2 . ILE A 1 103 ? 144.120 159.484 150.607 1.00 30.04  ? 68   ILE A CG2 1 
ATOM   416  C  CD1 . ILE A 1 103 ? 142.866 157.479 148.145 1.00 30.04  ? 68   ILE A CD1 1 
ATOM   417  N  N   . GLU A 1 104 ? 141.908 161.256 152.338 1.00 38.29  ? 69   GLU A N   1 
ATOM   418  C  CA  . GLU A 1 104 ? 141.239 161.333 153.632 1.00 38.29  ? 69   GLU A CA  1 
ATOM   419  C  C   . GLU A 1 104 ? 139.835 161.902 153.486 1.00 38.29  ? 69   GLU A C   1 
ATOM   420  O  O   . GLU A 1 104 ? 138.889 161.409 154.111 1.00 38.29  ? 69   GLU A O   1 
ATOM   421  C  CB  . GLU A 1 104 ? 142.054 162.201 154.589 1.00 38.29  ? 69   GLU A CB  1 
ATOM   422  C  CG  . GLU A 1 104 ? 142.000 161.786 156.043 1.00 38.29  ? 69   GLU A CG  1 
ATOM   423  C  CD  . GLU A 1 104 ? 142.946 162.601 156.900 1.00 38.29  ? 69   GLU A CD  1 
ATOM   424  O  OE1 . GLU A 1 104 ? 142.867 163.845 156.845 1.00 38.29  ? 69   GLU A OE1 1 
ATOM   425  O  OE2 . GLU A 1 104 ? 143.772 162.005 157.621 1.00 38.29  ? 69   GLU A OE2 1 
ATOM   426  N  N   . VAL A 1 105 ? 139.691 162.953 152.675 1.00 38.21  ? 70   VAL A N   1 
ATOM   427  C  CA  . VAL A 1 105 ? 138.387 163.582 152.468 1.00 38.21  ? 70   VAL A CA  1 
ATOM   428  C  C   . VAL A 1 105 ? 137.416 162.633 151.768 1.00 38.21  ? 70   VAL A C   1 
ATOM   429  O  O   . VAL A 1 105 ? 136.216 162.630 152.073 1.00 38.21  ? 70   VAL A O   1 
ATOM   430  C  CB  . VAL A 1 105 ? 138.563 164.903 151.694 1.00 38.21  ? 70   VAL A CB  1 
ATOM   431  C  CG1 . VAL A 1 105 ? 137.226 165.469 151.244 1.00 38.21  ? 70   VAL A CG1 1 
ATOM   432  C  CG2 . VAL A 1 105 ? 139.275 165.917 152.557 1.00 38.21  ? 70   VAL A CG2 1 
ATOM   433  N  N   . ILE A 1 106 ? 137.915 161.801 150.847 1.00 39.38  ? 71   ILE A N   1 
ATOM   434  C  CA  . ILE A 1 106 ? 137.047 160.923 150.058 1.00 39.38  ? 71   ILE A CA  1 
ATOM   435  C  C   . ILE A 1 106 ? 136.284 159.952 150.955 1.00 39.38  ? 71   ILE A C   1 
ATOM   436  O  O   . ILE A 1 106 ? 135.076 159.747 150.790 1.00 39.38  ? 71   ILE A O   1 
ATOM   437  C  CB  . ILE A 1 106 ? 137.867 160.168 148.995 1.00 39.38  ? 71   ILE A CB  1 
ATOM   438  C  CG1 . ILE A 1 106 ? 138.480 161.137 147.987 1.00 39.38  ? 71   ILE A CG1 1 
ATOM   439  C  CG2 . ILE A 1 106 ? 137.007 159.148 148.273 1.00 39.38  ? 71   ILE A CG2 1 
ATOM   440  C  CD1 . ILE A 1 106 ? 137.499 162.125 147.422 1.00 39.38  ? 71   ILE A CD1 1 
ATOM   441  N  N   . THR A 1 107 ? 136.970 159.349 151.923 1.00 39.78  ? 72   THR A N   1 
ATOM   442  C  CA  . THR A 1 107 ? 136.398 158.281 152.741 1.00 39.78  ? 72   THR A CA  1 
ATOM   443  C  C   . THR A 1 107 ? 136.016 158.757 154.138 1.00 39.78  ? 72   THR A C   1 
ATOM   444  O  O   . THR A 1 107 ? 136.191 158.026 155.116 1.00 39.78  ? 72   THR A O   1 
ATOM   445  C  CB  . THR A 1 107 ? 137.370 157.110 152.828 1.00 39.78  ? 72   THR A CB  1 
ATOM   446  O  OG1 . THR A 1 107 ? 138.556 157.525 153.515 1.00 39.78  ? 72   THR A OG1 1 
ATOM   447  C  CG2 . THR A 1 107 ? 137.747 156.637 151.436 1.00 39.78  ? 72   THR A CG2 1 
ATOM   448  N  N   . SER A 1 108 ? 135.484 159.969 154.264 1.00 46.07  ? 73   SER A N   1 
ATOM   449  C  CA  . SER A 1 108 ? 135.145 160.549 155.557 1.00 46.07  ? 73   SER A CA  1 
ATOM   450  C  C   . SER A 1 108 ? 133.641 160.754 155.655 1.00 46.07  ? 73   SER A C   1 
ATOM   451  O  O   . SER A 1 108 ? 133.012 161.229 154.704 1.00 46.07  ? 73   SER A O   1 
ATOM   452  C  CB  . SER A 1 108 ? 135.867 161.880 155.766 1.00 46.07  ? 73   SER A CB  1 
ATOM   453  O  OG  . SER A 1 108 ? 135.466 162.829 154.795 1.00 46.07  ? 73   SER A OG  1 
ATOM   454  N  N   . GLN A 1 109 ? 133.071 160.394 156.803 1.00 56.51  ? 74   GLN A N   1 
ATOM   455  C  CA  . GLN A 1 109 ? 131.653 160.608 157.053 1.00 56.51  ? 74   GLN A CA  1 
ATOM   456  C  C   . GLN A 1 109 ? 131.401 162.049 157.484 1.00 56.51  ? 74   GLN A C   1 
ATOM   457  O  O   . GLN A 1 109 ? 132.125 162.601 158.317 1.00 56.51  ? 74   GLN A O   1 
ATOM   458  C  CB  . GLN A 1 109 ? 131.151 159.635 158.122 1.00 56.51  ? 74   GLN A CB  1 
ATOM   459  C  CG  . GLN A 1 109 ? 129.885 160.072 158.842 1.00 56.51  ? 74   GLN A CG  1 
ATOM   460  C  CD  . GLN A 1 109 ? 129.540 159.173 160.010 1.00 56.51  ? 74   GLN A CD  1 
ATOM   461  O  OE1 . GLN A 1 109 ? 130.317 158.293 160.381 1.00 56.51  ? 74   GLN A OE1 1 
ATOM   462  N  NE2 . GLN A 1 109 ? 128.370 159.390 160.600 1.00 56.51  ? 74   GLN A NE2 1 
ATOM   463  N  N   . GLU A 1 110 ? 130.365 162.654 156.910 1.00 65.45  ? 75   GLU A N   1 
ATOM   464  C  CA  . GLU A 1 110 ? 130.028 164.047 157.155 1.00 65.45  ? 75   GLU A CA  1 
ATOM   465  C  C   . GLU A 1 110 ? 129.150 164.174 158.397 1.00 65.45  ? 75   GLU A C   1 
ATOM   466  O  O   . GLU A 1 110 ? 128.287 163.332 158.659 1.00 65.45  ? 75   GLU A O   1 
ATOM   467  C  CB  . GLU A 1 110 ? 129.313 164.626 155.931 1.00 65.45  ? 75   GLU A CB  1 
ATOM   468  C  CG  . GLU A 1 110 ? 128.925 166.090 156.016 1.00 65.45  ? 75   GLU A CG  1 
ATOM   469  C  CD  . GLU A 1 110 ? 129.022 166.780 154.668 1.00 65.45  ? 75   GLU A CD  1 
ATOM   470  O  OE1 . GLU A 1 110 ? 129.288 167.998 154.628 1.00 65.45  ? 75   GLU A OE1 1 
ATOM   471  O  OE2 . GLU A 1 110 ? 128.833 166.096 153.641 1.00 65.45  ? 75   GLU A OE2 1 
ATOM   472  N  N   . LYS A 1 111 ? 129.380 165.239 159.165 1.00 62.57  ? 76   LYS A N   1 
ATOM   473  C  CA  . LYS A 1 111 ? 128.630 165.494 160.387 1.00 62.57  ? 76   LYS A CA  1 
ATOM   474  C  C   . LYS A 1 111 ? 128.229 166.961 160.440 1.00 62.57  ? 76   LYS A C   1 
ATOM   475  O  O   . LYS A 1 111 ? 128.929 167.831 159.917 1.00 62.57  ? 76   LYS A O   1 
ATOM   476  C  CB  . LYS A 1 111 ? 129.444 165.130 161.637 1.00 62.57  ? 76   LYS A CB  1 
ATOM   477  C  CG  . LYS A 1 111 ? 128.611 164.729 162.843 1.00 62.57  ? 76   LYS A CG  1 
ATOM   478  C  CD  . LYS A 1 111 ? 128.211 163.267 162.772 1.00 62.57  ? 76   LYS A CD  1 
ATOM   479  C  CE  . LYS A 1 111 ? 127.462 162.840 164.020 1.00 62.57  ? 76   LYS A CE  1 
ATOM   480  N  NZ  . LYS A 1 111 ? 126.234 163.650 164.236 1.00 62.57  ? 76   LYS A NZ  1 
ATOM   481  N  N   . GLU A 1 112 ? 127.092 167.226 161.081 1.00 70.95  ? 77   GLU A N   1 
ATOM   482  C  CA  . GLU A 1 112 ? 126.557 168.574 161.231 1.00 70.95  ? 77   GLU A CA  1 
ATOM   483  C  C   . GLU A 1 112 ? 126.501 168.931 162.708 1.00 70.95  ? 77   GLU A C   1 
ATOM   484  O  O   . GLU A 1 112 ? 125.977 168.158 163.517 1.00 70.95  ? 77   GLU A O   1 
ATOM   485  C  CB  . GLU A 1 112 ? 125.165 168.687 160.606 1.00 70.95  ? 77   GLU A CB  1 
ATOM   486  C  CG  . GLU A 1 112 ? 124.582 170.088 160.638 1.00 70.95  ? 77   GLU A CG  1 
ATOM   487  C  CD  . GLU A 1 112 ? 123.204 170.159 160.012 1.00 70.95  ? 77   GLU A CD  1 
ATOM   488  O  OE1 . GLU A 1 112 ? 122.697 169.106 159.572 1.00 70.95  ? 77   GLU A OE1 1 
ATOM   489  O  OE2 . GLU A 1 112 ? 122.628 171.265 159.962 1.00 70.95  ? 77   GLU A OE2 1 
ATOM   490  N  N   . ILE A 1 113 ? 127.024 170.105 163.055 1.00 70.55  ? 78   ILE A N   1 
ATOM   491  C  CA  . ILE A 1 113 ? 127.140 170.562 164.432 1.00 70.55  ? 78   ILE A CA  1 
ATOM   492  C  C   . ILE A 1 113 ? 126.391 171.881 164.556 1.00 70.55  ? 78   ILE A C   1 
ATOM   493  O  O   . ILE A 1 113 ? 126.581 172.790 163.737 1.00 70.55  ? 78   ILE A O   1 
ATOM   494  C  CB  . ILE A 1 113 ? 128.615 170.733 164.845 1.00 70.55  ? 78   ILE A CB  1 
ATOM   495  C  CG1 . ILE A 1 113 ? 129.369 169.401 164.780 1.00 70.55  ? 78   ILE A CG1 1 
ATOM   496  C  CG2 . ILE A 1 113 ? 128.720 171.318 166.239 1.00 70.55  ? 78   ILE A CG2 1 
ATOM   497  C  CD1 . ILE A 1 113 ? 128.640 168.234 165.400 1.00 70.55  ? 78   ILE A CD1 1 
ATOM   498  N  N   . THR A 1 114 ? 125.535 171.981 165.571 1.00 77.17  ? 79   THR A N   1 
ATOM   499  C  CA  . THR A 1 114 ? 124.836 173.223 165.895 1.00 77.17  ? 79   THR A CA  1 
ATOM   500  C  C   . THR A 1 114 ? 125.553 173.839 167.092 1.00 77.17  ? 79   THR A C   1 
ATOM   501  O  O   . THR A 1 114 ? 125.261 173.525 168.246 1.00 77.17  ? 79   THR A O   1 
ATOM   502  C  CB  . THR A 1 114 ? 123.363 172.967 166.185 1.00 77.17  ? 79   THR A CB  1 
ATOM   503  O  OG1 . THR A 1 114 ? 123.236 172.272 167.432 1.00 77.17  ? 79   THR A OG1 1 
ATOM   504  C  CG2 . THR A 1 114 ? 122.742 172.128 165.078 1.00 77.17  ? 79   THR A CG2 1 
ATOM   505  N  N   . ILE A 1 115 ? 126.499 174.726 166.804 1.00 83.70  ? 80   ILE A N   1 
ATOM   506  C  CA  . ILE A 1 115 ? 127.317 175.342 167.842 1.00 83.70  ? 80   ILE A CA  1 
ATOM   507  C  C   . ILE A 1 115 ? 126.483 176.373 168.588 1.00 83.70  ? 80   ILE A C   1 
ATOM   508  O  O   . ILE A 1 115 ? 125.853 177.249 167.975 1.00 83.70  ? 80   ILE A O   1 
ATOM   509  C  CB  . ILE A 1 115 ? 128.576 175.981 167.237 1.00 83.70  ? 80   ILE A CB  1 
ATOM   510  C  CG1 . ILE A 1 115 ? 129.405 174.936 166.487 1.00 83.70  ? 80   ILE A CG1 1 
ATOM   511  C  CG2 . ILE A 1 115 ? 129.405 176.663 168.320 1.00 83.70  ? 80   ILE A CG2 1 
ATOM   512  C  CD1 . ILE A 1 115 ? 130.786 175.415 166.083 1.00 83.70  ? 80   ILE A CD1 1 
ATOM   513  N  N   . LYS A 1 116 ? 126.483 176.267 169.916 1.00 87.89  ? 81   LYS A N   1 
ATOM   514  C  CA  . LYS A 1 116 ? 125.774 177.177 170.805 1.00 87.89  ? 81   LYS A CA  1 
ATOM   515  C  C   . LYS A 1 116 ? 126.747 178.227 171.323 1.00 87.89  ? 81   LYS A C   1 
ATOM   516  O  O   . LYS A 1 116 ? 127.875 177.899 171.706 1.00 87.89  ? 81   LYS A O   1 
ATOM   517  C  CB  . LYS A 1 116 ? 125.151 176.417 171.979 1.00 87.89  ? 81   LYS A CB  1 
ATOM   518  C  CG  . LYS A 1 116 ? 123.833 175.723 171.670 1.00 87.89  ? 81   LYS A CG  1 
ATOM   519  C  CD  . LYS A 1 116 ? 123.252 175.074 172.917 1.00 87.89  ? 81   LYS A CD  1 
ATOM   520  C  CE  . LYS A 1 116 ? 121.893 174.446 172.645 1.00 87.89  ? 81   LYS A CE  1 
ATOM   521  N  NZ  . LYS A 1 116 ? 120.849 175.456 172.313 1.00 87.89  ? 81   LYS A NZ  1 
ATOM   522  N  N   . LYS A 1 117 ? 126.311 179.481 171.330 1.00 96.12  ? 82   LYS A N   1 
ATOM   523  C  CA  . LYS A 1 117 ? 127.141 180.604 171.748 1.00 96.12  ? 82   LYS A CA  1 
ATOM   524  C  C   . LYS A 1 117 ? 126.279 181.539 172.596 1.00 96.12  ? 82   LYS A C   1 
ATOM   525  O  O   . LYS A 1 117 ? 125.069 181.298 172.707 1.00 96.12  ? 82   LYS A O   1 
ATOM   526  C  CB  . LYS A 1 117 ? 127.736 181.289 170.511 1.00 96.12  ? 82   LYS A CB  1 
ATOM   527  C  CG  . LYS A 1 117 ? 128.990 180.606 169.980 1.00 96.12  ? 82   LYS A CG  1 
ATOM   528  C  CD  . LYS A 1 117 ? 129.980 180.330 171.102 1.00 96.12  ? 82   LYS A CD  1 
ATOM   529  C  CE  . LYS A 1 117 ? 131.165 179.517 170.611 1.00 96.12  ? 82   LYS A CE  1 
ATOM   530  N  NZ  . LYS A 1 117 ? 132.079 179.146 171.728 1.00 96.12  ? 82   LYS A NZ  1 
ATOM   531  N  N   . PRO A 1 118 ? 126.837 182.573 173.243 1.00 98.69  ? 83   PRO A N   1 
ATOM   532  C  CA  . PRO A 1 118 ? 125.985 183.473 174.045 1.00 98.69  ? 83   PRO A CA  1 
ATOM   533  C  C   . PRO A 1 118 ? 124.898 184.189 173.258 1.00 98.69  ? 83   PRO A C   1 
ATOM   534  O  O   . PRO A 1 118 ? 123.910 184.621 173.865 1.00 98.69  ? 83   PRO A O   1 
ATOM   535  C  CB  . PRO A 1 118 ? 126.989 184.468 174.649 1.00 98.69  ? 83   PRO A CB  1 
ATOM   536  C  CG  . PRO A 1 118 ? 128.243 184.302 173.853 1.00 98.69  ? 83   PRO A CG  1 
ATOM   537  C  CD  . PRO A 1 118 ? 128.262 182.854 173.500 1.00 98.69  ? 83   PRO A CD  1 
ATOM   538  N  N   . ASN A 1 119 ? 125.039 184.342 171.944 1.00 101.75 ? 84   ASN A N   1 
ATOM   539  C  CA  . ASN A 1 119 ? 123.936 184.865 171.150 1.00 101.75 ? 84   ASN A CA  1 
ATOM   540  C  C   . ASN A 1 119 ? 122.821 183.828 171.054 1.00 101.75 ? 84   ASN A C   1 
ATOM   541  O  O   . ASN A 1 119 ? 123.055 182.621 171.158 1.00 101.75 ? 84   ASN A O   1 
ATOM   542  C  CB  . ASN A 1 119 ? 124.410 185.269 169.752 1.00 101.75 ? 84   ASN A CB  1 
ATOM   543  C  CG  . ASN A 1 119 ? 124.911 184.093 168.935 1.00 101.75 ? 84   ASN A CG  1 
ATOM   544  O  OD1 . ASN A 1 119 ? 125.331 183.075 169.479 1.00 101.75 ? 84   ASN A OD1 1 
ATOM   545  N  ND2 . ASN A 1 119 ? 124.865 184.230 167.615 1.00 101.75 ? 84   ASN A ND2 1 
ATOM   546  N  N   . GLY A 1 120 ? 121.592 184.316 170.873 1.00 99.81  ? 85   GLY A N   1 
ATOM   547  C  CA  . GLY A 1 120 ? 120.450 183.417 170.806 1.00 99.81  ? 85   GLY A CA  1 
ATOM   548  C  C   . GLY A 1 120 ? 120.509 182.472 169.621 1.00 99.81  ? 85   GLY A C   1 
ATOM   549  O  O   . GLY A 1 120 ? 120.166 181.293 169.736 1.00 99.81  ? 85   GLY A O   1 
ATOM   550  N  N   . GLU A 1 121 ? 120.942 182.975 168.469 1.00 101.11 ? 86   GLU A N   1 
ATOM   551  C  CA  . GLU A 1 121 ? 121.059 182.139 167.284 1.00 101.11 ? 86   GLU A CA  1 
ATOM   552  C  C   . GLU A 1 121 ? 122.254 181.200 167.408 1.00 101.11 ? 86   GLU A C   1 
ATOM   553  O  O   . GLU A 1 121 ? 123.305 181.570 167.938 1.00 101.11 ? 86   GLU A O   1 
ATOM   554  C  CB  . GLU A 1 121 ? 121.194 183.011 166.037 1.00 101.11 ? 86   GLU A CB  1 
ATOM   555  C  CG  . GLU A 1 121 ? 119.984 183.896 165.777 1.00 101.11 ? 86   GLU A CG  1 
ATOM   556  C  CD  . GLU A 1 121 ? 120.003 184.523 164.399 1.00 101.11 ? 86   GLU A CD  1 
ATOM   557  O  OE1 . GLU A 1 121 ? 120.842 184.113 163.570 1.00 101.11 ? 86   GLU A OE1 1 
ATOM   558  O  OE2 . GLU A 1 121 ? 119.180 185.428 164.145 1.00 101.11 ? 86   GLU A OE2 1 
ATOM   559  N  N   . THR A 1 122 ? 122.088 179.979 166.908 1.00 91.97  ? 87   THR A N   1 
ATOM   560  C  CA  . THR A 1 122 ? 123.111 178.945 166.985 1.00 91.97  ? 87   THR A CA  1 
ATOM   561  C  C   . THR A 1 122 ? 123.684 178.693 165.599 1.00 91.97  ? 87   THR A C   1 
ATOM   562  O  O   . THR A 1 122 ? 122.933 178.511 164.635 1.00 91.97  ? 87   THR A O   1 
ATOM   563  C  CB  . THR A 1 122 ? 122.541 177.650 167.565 1.00 91.97  ? 87   THR A CB  1 
ATOM   564  O  OG1 . THR A 1 122 ? 121.283 177.359 166.944 1.00 91.97  ? 87   THR A OG1 1 
ATOM   565  C  CG2 . THR A 1 122 ? 122.344 177.789 169.061 1.00 91.97  ? 87   THR A CG2 1 
ATOM   566  N  N   . THR A 1 123 ? 125.010 178.682 165.502 1.00 86.97  ? 88   THR A N   1 
ATOM   567  C  CA  . THR A 1 123 ? 125.658 178.580 164.203 1.00 86.97  ? 88   THR A CA  1 
ATOM   568  C  C   . THR A 1 123 ? 125.659 177.137 163.709 1.00 86.97  ? 88   THR A C   1 
ATOM   569  O  O   . THR A 1 123 ? 125.632 176.189 164.495 1.00 86.97  ? 88   THR A O   1 
ATOM   570  C  CB  . THR A 1 123 ? 127.089 179.111 164.272 1.00 86.97  ? 88   THR A CB  1 
ATOM   571  O  OG1 . THR A 1 123 ? 127.832 178.367 165.242 1.00 86.97  ? 88   THR A OG1 1 
ATOM   572  C  CG2 . THR A 1 123 ? 127.090 180.577 164.668 1.00 86.97  ? 88   THR A CG2 1 
ATOM   573  N  N   . LYS A 1 124 ? 125.677 176.978 162.389 1.00 82.81  ? 89   LYS A N   1 
ATOM   574  C  CA  . LYS A 1 124 ? 125.756 175.668 161.757 1.00 82.81  ? 89   LYS A CA  1 
ATOM   575  C  C   . LYS A 1 124 ? 127.153 175.460 161.193 1.00 82.81  ? 89   LYS A C   1 
ATOM   576  O  O   . LYS A 1 124 ? 127.636 176.277 160.402 1.00 82.81  ? 89   LYS A O   1 
ATOM   577  C  CB  . LYS A 1 124 ? 124.706 175.523 160.654 1.00 82.81  ? 89   LYS A CB  1 
ATOM   578  C  CG  . LYS A 1 124 ? 123.279 175.740 161.127 1.00 82.81  ? 89   LYS A CG  1 
ATOM   579  C  CD  . LYS A 1 124 ? 122.885 174.688 162.155 1.00 82.81  ? 89   LYS A CD  1 
ATOM   580  C  CE  . LYS A 1 124 ? 121.405 174.759 162.491 1.00 82.81  ? 89   LYS A CE  1 
ATOM   581  N  NZ  . LYS A 1 124 ? 121.078 175.950 163.320 1.00 82.81  ? 89   LYS A NZ  1 
ATOM   582  N  N   . THR A 1 125 ? 127.797 174.368 161.597 1.00 73.03  ? 90   THR A N   1 
ATOM   583  C  CA  . THR A 1 125 ? 129.164 174.072 161.200 1.00 73.03  ? 90   THR A CA  1 
ATOM   584  C  C   . THR A 1 125 ? 129.231 172.620 160.744 1.00 73.03  ? 90   THR A C   1 
ATOM   585  O  O   . THR A 1 125 ? 128.514 171.761 161.258 1.00 73.03  ? 90   THR A O   1 
ATOM   586  C  CB  . THR A 1 125 ? 130.136 174.366 162.377 1.00 73.03  ? 90   THR A CB  1 
ATOM   587  O  OG1 . THR A 1 125 ? 130.399 175.774 162.434 1.00 73.03  ? 90   THR A OG1 1 
ATOM   588  C  CG2 . THR A 1 125 ? 131.463 173.623 162.251 1.00 73.03  ? 90   THR A CG2 1 
ATOM   589  N  N   . THR A 1 126 ? 130.052 172.354 159.735 1.00 66.77  ? 91   THR A N   1 
ATOM   590  C  CA  . THR A 1 126 ? 130.269 170.997 159.259 1.00 66.77  ? 91   THR A CA  1 
ATOM   591  C  C   . THR A 1 126 ? 131.659 170.530 159.664 1.00 66.77  ? 91   THR A C   1 
ATOM   592  O  O   . THR A 1 126 ? 132.658 171.176 159.332 1.00 66.77  ? 91   THR A O   1 
ATOM   593  C  CB  . THR A 1 126 ? 130.108 170.908 157.742 1.00 66.77  ? 91   THR A CB  1 
ATOM   594  O  OG1 . THR A 1 126 ? 128.796 171.348 157.369 1.00 66.77  ? 91   THR A OG1 1 
ATOM   595  C  CG2 . THR A 1 126 ? 130.310 169.479 157.282 1.00 66.77  ? 91   THR A CG2 1 
ATOM   596  N  N   . VAL A 1 127 ? 131.715 169.415 160.385 1.00 56.40  ? 92   VAL A N   1 
ATOM   597  C  CA  . VAL A 1 127 ? 132.961 168.713 160.653 1.00 56.40  ? 92   VAL A CA  1 
ATOM   598  C  C   . VAL A 1 127 ? 132.825 167.311 160.081 1.00 56.40  ? 92   VAL A C   1 
ATOM   599  O  O   . VAL A 1 127 ? 131.719 166.776 159.955 1.00 56.40  ? 92   VAL A O   1 
ATOM   600  C  CB  . VAL A 1 127 ? 133.322 168.675 162.158 1.00 56.40  ? 92   VAL A CB  1 
ATOM   601  C  CG1 . VAL A 1 127 ? 133.064 170.024 162.804 1.00 56.40  ? 92   VAL A CG1 1 
ATOM   602  C  CG2 . VAL A 1 127 ? 132.552 167.586 162.887 1.00 56.40  ? 92   VAL A CG2 1 
ATOM   603  N  N   . ARG A 1 128 ? 133.951 166.737 159.683 1.00 54.20  ? 93   ARG A N   1 
ATOM   604  C  CA  . ARG A 1 128 ? 133.974 165.405 159.108 1.00 54.20  ? 93   ARG A CA  1 
ATOM   605  C  C   . ARG A 1 128 ? 134.672 164.448 160.060 1.00 54.20  ? 93   ARG A C   1 
ATOM   606  O  O   . ARG A 1 128 ? 135.459 164.856 160.917 1.00 54.20  ? 93   ARG A O   1 
ATOM   607  C  CB  . ARG A 1 128 ? 134.673 165.413 157.746 1.00 54.20  ? 93   ARG A CB  1 
ATOM   608  C  CG  . ARG A 1 128 ? 134.047 166.370 156.749 1.00 54.20  ? 93   ARG A CG  1 
ATOM   609  C  CD  . ARG A 1 128 ? 134.933 166.563 155.533 1.00 54.20  ? 93   ARG A CD  1 
ATOM   610  N  NE  . ARG A 1 128 ? 134.149 166.692 154.311 1.00 54.20  ? 93   ARG A NE  1 
ATOM   611  C  CZ  . ARG A 1 128 ? 133.563 165.685 153.679 1.00 54.20  ? 93   ARG A CZ  1 
ATOM   612  N  NH1 . ARG A 1 128 ? 133.664 164.442 154.116 1.00 54.20  ? 93   ARG A NH1 1 
ATOM   613  N  NH2 . ARG A 1 128 ? 132.859 165.932 152.578 1.00 54.20  ? 93   ARG A NH2 1 
ATOM   614  N  N   . ILE A 1 129 ? 134.383 163.153 159.939 1.00 49.87  ? 94   ILE A N   1 
ATOM   615  C  CA  . ILE A 1 129 ? 134.971 162.186 160.911 1.00 49.87  ? 94   ILE A CA  1 
ATOM   616  C  C   . ILE A 1 129 ? 135.681 161.064 160.151 1.00 49.87  ? 94   ILE A C   1 
ATOM   617  O  O   . ILE A 1 129 ? 135.058 160.007 159.964 1.00 49.87  ? 94   ILE A O   1 
ATOM   618  C  CB  . ILE A 1 129 ? 133.898 161.627 161.868 1.00 49.87  ? 94   ILE A CB  1 
ATOM   619  C  CG1 . ILE A 1 129 ? 132.914 162.700 162.337 1.00 49.87  ? 94   ILE A CG1 1 
ATOM   620  C  CG2 . ILE A 1 129 ? 134.542 160.910 163.046 1.00 49.87  ? 94   ILE A CG2 1 
ATOM   621  C  CD1 . ILE A 1 129 ? 131.843 162.175 163.260 1.00 49.87  ? 94   ILE A CD1 1 
ATOM   622  N  N   . TRP A 1 130 ? 136.944 161.257 159.759 1.00 40.09  ? 95   TRP A N   1 
ATOM   623  C  CA  . TRP A 1 130 ? 137.702 160.149 159.118 1.00 40.09  ? 95   TRP A CA  1 
ATOM   624  C  C   . TRP A 1 130 ? 138.024 159.103 160.182 1.00 40.09  ? 95   TRP A C   1 
ATOM   625  O  O   . TRP A 1 130 ? 138.642 159.471 161.191 1.00 40.09  ? 95   TRP A O   1 
ATOM   626  C  CB  . TRP A 1 130 ? 138.985 160.650 158.456 1.00 40.09  ? 95   TRP A CB  1 
ATOM   627  C  CG  . TRP A 1 130 ? 139.696 159.599 157.661 1.00 40.09  ? 95   TRP A CG  1 
ATOM   628  C  CD1 . TRP A 1 130 ? 139.282 159.041 156.487 1.00 40.09  ? 95   TRP A CD1 1 
ATOM   629  C  CD2 . TRP A 1 130 ? 140.955 158.977 157.973 1.00 40.09  ? 95   TRP A CD2 1 
ATOM   630  N  NE1 . TRP A 1 130 ? 140.192 158.117 156.050 1.00 40.09  ? 95   TRP A NE1 1 
ATOM   631  C  CE2 . TRP A 1 130 ? 141.229 158.056 156.940 1.00 40.09  ? 95   TRP A CE2 1 
ATOM   632  C  CE3 . TRP A 1 130 ? 141.876 159.108 159.017 1.00 40.09  ? 95   TRP A CE3 1 
ATOM   633  C  CZ2 . TRP A 1 130 ? 142.381 157.273 156.926 1.00 40.09  ? 95   TRP A CZ2 1 
ATOM   634  C  CZ3 . TRP A 1 130 ? 143.014 158.333 159.002 1.00 40.09  ? 95   TRP A CZ3 1 
ATOM   635  C  CH2 . TRP A 1 130 ? 143.260 157.428 157.971 1.00 40.09  ? 95   TRP A CH2 1 
ATOM   636  N  N   . ASN A 1 131 ? 137.631 157.851 159.957 1.00 40.71  ? 96   ASN A N   1 
ATOM   637  C  CA  . ASN A 1 131 ? 137.847 156.793 160.976 1.00 40.71  ? 96   ASN A CA  1 
ATOM   638  C  C   . ASN A 1 131 ? 139.044 155.946 160.552 1.00 40.71  ? 96   ASN A C   1 
ATOM   639  O  O   . ASN A 1 131 ? 139.031 155.447 159.416 1.00 40.71  ? 96   ASN A O   1 
ATOM   640  C  CB  . ASN A 1 131 ? 136.627 155.882 161.100 1.00 40.71  ? 96   ASN A CB  1 
ATOM   641  C  CG  . ASN A 1 131 ? 135.337 156.636 161.342 1.00 40.71  ? 96   ASN A CG  1 
ATOM   642  O  OD1 . ASN A 1 131 ? 135.352 157.756 161.844 1.00 40.71  ? 96   ASN A OD1 1 
ATOM   643  N  ND2 . ASN A 1 131 ? 134.215 156.027 160.995 1.00 40.71  ? 96   ASN A ND2 1 
ATOM   644  N  N   . GLU A 1 132 ? 140.020 155.762 161.441 1.00 37.93  ? 97   GLU A N   1 
ATOM   645  C  CA  . GLU A 1 132 ? 141.144 154.866 161.088 1.00 37.93  ? 97   GLU A CA  1 
ATOM   646  C  C   . GLU A 1 132 ? 140.601 153.440 161.102 1.00 37.93  ? 97   GLU A C   1 
ATOM   647  O  O   . GLU A 1 132 ? 140.160 152.996 162.174 1.00 37.93  ? 97   GLU A O   1 
ATOM   648  C  CB  . GLU A 1 132 ? 142.266 154.978 162.118 1.00 37.93  ? 97   GLU A CB  1 
ATOM   649  C  CG  . GLU A 1 132 ? 142.941 156.333 162.149 1.00 37.93  ? 97   GLU A CG  1 
ATOM   650  C  CD  . GLU A 1 132 ? 144.088 156.414 163.140 1.00 37.93  ? 97   GLU A CD  1 
ATOM   651  O  OE1 . GLU A 1 132 ? 144.720 157.484 163.231 1.00 37.93  ? 97   GLU A OE1 1 
ATOM   652  O  OE2 . GLU A 1 132 ? 144.346 155.402 163.819 1.00 37.93  ? 97   GLU A OE2 1 
ATOM   653  N  N   . THR A 1 133 ? 140.654 152.752 159.962 1.00 42.92  ? 98   THR A N   1 
ATOM   654  C  CA  . THR A 1 133 ? 140.178 151.350 159.854 1.00 42.92  ? 98   THR A CA  1 
ATOM   655  C  C   . THR A 1 133 ? 141.158 150.635 158.929 1.00 42.92  ? 98   THR A C   1 
ATOM   656  O  O   . THR A 1 133 ? 141.847 151.337 158.181 1.00 42.92  ? 98   THR A O   1 
ATOM   657  C  CB  . THR A 1 133 ? 138.773 151.279 159.249 1.00 42.92  ? 98   THR A CB  1 
ATOM   658  O  OG1 . THR A 1 133 ? 138.796 151.970 158.001 1.00 42.92  ? 98   THR A OG1 1 
ATOM   659  C  CG2 . THR A 1 133 ? 137.700 151.869 160.139 1.00 42.92  ? 98   THR A CG2 1 
ATOM   660  N  N   . VAL A 1 134 ? 141.212 149.305 158.957 1.00 40.22  ? 99   VAL A N   1 
ATOM   661  C  CA  . VAL A 1 134 ? 142.243 148.604 158.137 1.00 40.22  ? 99   VAL A CA  1 
ATOM   662  C  C   . VAL A 1 134 ? 142.009 148.937 156.659 1.00 40.22  ? 99   VAL A C   1 
ATOM   663  O  O   . VAL A 1 134 ? 142.998 149.151 155.944 1.00 40.22  ? 99   VAL A O   1 
ATOM   664  C  CB  . VAL A 1 134 ? 142.275 147.093 158.426 1.00 40.22  ? 99   VAL A CB  1 
ATOM   665  C  CG1 . VAL A 1 134 ? 140.885 146.484 158.451 1.00 40.22  ? 99   VAL A CG1 1 
ATOM   666  C  CG2 . VAL A 1 134 ? 143.193 146.335 157.482 1.00 40.22  ? 99   VAL A CG2 1 
ATOM   667  N  N   . SER A 1 135 ? 140.750 149.017 156.226 1.00 44.43  ? 100  SER A N   1 
ATOM   668  C  CA  . SER A 1 135 ? 140.447 149.398 154.821 1.00 44.43  ? 100  SER A CA  1 
ATOM   669  C  C   . SER A 1 135 ? 140.918 150.824 154.515 1.00 44.43  ? 100  SER A C   1 
ATOM   670  O  O   . SER A 1 135 ? 141.455 151.026 153.417 1.00 44.43  ? 100  SER A O   1 
ATOM   671  C  CB  . SER A 1 135 ? 138.986 149.239 154.515 1.00 44.43  ? 100  SER A CB  1 
ATOM   672  O  OG  . SER A 1 135 ? 138.723 149.563 153.159 1.00 44.43  ? 100  SER A OG  1 
ATOM   673  N  N   . ASN A 1 136 ? 140.719 151.774 155.432 1.00 38.74  ? 101  ASN A N   1 
ATOM   674  C  CA  . ASN A 1 136 ? 141.072 153.190 155.139 1.00 38.74  ? 101  ASN A CA  1 
ATOM   675  C  C   . ASN A 1 136 ? 142.586 153.376 155.251 1.00 38.74  ? 101  ASN A C   1 
ATOM   676  O  O   . ASN A 1 136 ? 143.127 154.183 154.484 1.00 38.74  ? 101  ASN A O   1 
ATOM   677  C  CB  . ASN A 1 136 ? 140.317 154.187 156.021 1.00 38.74  ? 101  ASN A CB  1 
ATOM   678  C  CG  . ASN A 1 136 ? 138.870 154.362 155.617 1.00 38.74  ? 101  ASN A CG  1 
ATOM   679  O  OD1 . ASN A 1 136 ? 138.433 153.815 154.609 1.00 38.74  ? 101  ASN A OD1 1 
ATOM   680  N  ND2 . ASN A 1 136 ? 138.122 155.126 156.396 1.00 38.74  ? 101  ASN A ND2 1 
ATOM   681  N  N   . LEU A 1 137 ? 143.234 152.665 156.173 1.00 29.83  ? 102  LEU A N   1 
ATOM   682  C  CA  . LEU A 1 137 ? 144.711 152.741 156.297 1.00 29.83  ? 102  LEU A CA  1 
ATOM   683  C  C   . LEU A 1 137 ? 145.357 152.199 155.020 1.00 29.83  ? 102  LEU A C   1 
ATOM   684  O  O   . LEU A 1 137 ? 146.376 152.761 154.616 1.00 29.83  ? 102  LEU A O   1 
ATOM   685  C  CB  . LEU A 1 137 ? 145.175 151.976 157.538 1.00 29.83  ? 102  LEU A CB  1 
ATOM   686  C  CG  . LEU A 1 137 ? 144.841 152.635 158.873 1.00 29.83  ? 102  LEU A CG  1 
ATOM   687  C  CD1 . LEU A 1 137 ? 145.234 151.733 160.031 1.00 29.83  ? 102  LEU A CD1 1 
ATOM   688  C  CD2 . LEU A 1 137 ? 145.527 153.986 158.992 1.00 29.83  ? 102  LEU A CD2 1 
ATOM   689  N  N   . THR A 1 138 ? 144.794 151.143 154.424 1.00 31.20  ? 103  THR A N   1 
ATOM   690  C  CA  . THR A 1 138 ? 145.334 150.598 153.149 1.00 31.20  ? 103  THR A CA  1 
ATOM   691  C  C   . THR A 1 138 ? 145.225 151.650 152.042 1.00 31.20  ? 103  THR A C   1 
ATOM   692  O  O   . THR A 1 138 ? 146.200 151.803 151.300 1.00 31.20  ? 103  THR A O   1 
ATOM   693  C  CB  . THR A 1 138 ? 144.624 149.303 152.741 1.00 31.20  ? 103  THR A CB  1 
ATOM   694  O  OG1 . THR A 1 138 ? 144.894 148.329 153.748 1.00 31.20  ? 103  THR A OG1 1 
ATOM   695  C  CG2 . THR A 1 138 ? 145.070 148.774 151.397 1.00 31.20  ? 103  THR A CG2 1 
ATOM   696  N  N   . LEU A 1 139 ? 144.094 152.355 151.948 1.00 27.75  ? 104  LEU A N   1 
ATOM   697  C  CA  . LEU A 1 139 ? 143.924 153.422 150.925 1.00 27.75  ? 104  LEU A CA  1 
ATOM   698  C  C   . LEU A 1 139 ? 144.906 154.561 151.197 1.00 27.75  ? 104  LEU A C   1 
ATOM   699  O  O   . LEU A 1 139 ? 145.487 155.065 150.234 1.00 27.75  ? 104  LEU A O   1 
ATOM   700  C  CB  . LEU A 1 139 ? 142.480 153.926 150.937 1.00 27.75  ? 104  LEU A CB  1 
ATOM   701  C  CG  . LEU A 1 139 ? 141.423 152.883 150.581 1.00 27.75  ? 104  LEU A CG  1 
ATOM   702  C  CD1 . LEU A 1 139 ? 140.025 153.459 150.729 1.00 27.75  ? 104  LEU A CD1 1 
ATOM   703  C  CD2 . LEU A 1 139 ? 141.639 152.355 149.172 1.00 27.75  ? 104  LEU A CD2 1 
ATOM   704  N  N   . MET A 1 140 ? 145.074 154.954 152.460 1.00 27.06  ? 105  MET A N   1 
ATOM   705  C  CA  . MET A 1 140 ? 146.066 156.004 152.808 1.00 27.06  ? 105  MET A CA  1 
ATOM   706  C  C   . MET A 1 140 ? 147.465 155.479 152.491 1.00 27.06  ? 105  MET A C   1 
ATOM   707  O  O   . MET A 1 140 ? 148.273 156.266 152.007 1.00 27.06  ? 105  MET A O   1 
ATOM   708  C  CB  . MET A 1 140 ? 146.003 156.370 154.290 1.00 27.06  ? 105  MET A CB  1 
ATOM   709  C  CG  . MET A 1 140 ? 146.492 157.765 154.603 1.00 27.06  ? 105  MET A CG  1 
ATOM   710  S  SD  . MET A 1 140 ? 145.247 159.009 154.202 1.00 27.06  ? 105  MET A SD  1 
ATOM   711  C  CE  . MET A 1 140 ? 145.819 160.378 155.206 1.00 27.06  ? 105  MET A CE  1 
ATOM   712  N  N   . ALA A 1 141 ? 147.740 154.205 152.786 1.00 23.70  ? 106  ALA A N   1 
ATOM   713  C  CA  . ALA A 1 141 ? 149.061 153.605 152.483 1.00 23.70  ? 106  ALA A CA  1 
ATOM   714  C  C   . ALA A 1 141 ? 149.282 153.585 150.974 1.00 23.70  ? 106  ALA A C   1 
ATOM   715  O  O   . ALA A 1 141 ? 150.374 153.944 150.563 1.00 23.70  ? 106  ALA A O   1 
ATOM   716  C  CB  . ALA A 1 141 ? 149.150 152.215 153.050 1.00 23.70  ? 106  ALA A CB  1 
ATOM   717  N  N   . LEU A 1 142 ? 148.271 153.198 150.195 1.00 20.97  ? 107  LEU A N   1 
ATOM   718  C  CA  . LEU A 1 142 ? 148.362 153.189 148.712 1.00 20.97  ? 107  LEU A CA  1 
ATOM   719  C  C   . LEU A 1 142 ? 148.557 154.634 148.262 1.00 20.97  ? 107  LEU A C   1 
ATOM   720  O  O   . LEU A 1 142 ? 149.383 154.867 147.378 1.00 20.97  ? 107  LEU A O   1 
ATOM   721  C  CB  . LEU A 1 142 ? 147.027 152.651 148.192 1.00 20.97  ? 107  LEU A CB  1 
ATOM   722  C  CG  . LEU A 1 142 ? 146.960 152.149 146.754 1.00 20.97  ? 107  LEU A CG  1 
ATOM   723  C  CD1 . LEU A 1 142 ? 145.766 151.222 146.598 1.00 20.97  ? 107  LEU A CD1 1 
ATOM   724  C  CD2 . LEU A 1 142 ? 146.856 153.301 145.766 1.00 20.97  ? 107  LEU A CD2 1 
ATOM   725  N  N   . GLY A 1 143 ? 147.814 155.559 148.865 1.00 20.00  ? 108  GLY A N   1 
ATOM   726  C  CA  . GLY A 1 143 ? 147.937 156.981 148.514 1.00 20.00  ? 108  GLY A CA  1 
ATOM   727  C  C   . GLY A 1 143 ? 149.309 157.475 148.896 1.00 20.00  ? 108  GLY A C   1 
ATOM   728  O  O   . GLY A 1 143 ? 149.933 158.164 148.078 1.00 20.00  ? 108  GLY A O   1 
ATOM   729  N  N   . SER A 1 144 ? 149.770 157.127 150.099 1.00 20.75  ? 109  SER A N   1 
ATOM   730  C  CA  . SER A 1 144 ? 151.140 157.515 150.417 1.00 20.75  ? 109  SER A CA  1 
ATOM   731  C  C   . SER A 1 144 ? 152.159 156.782 149.549 1.00 20.75  ? 109  SER A C   1 
ATOM   732  O  O   . SER A 1 144 ? 153.253 157.304 149.313 1.00 20.75  ? 109  SER A O   1 
ATOM   733  C  CB  . SER A 1 144 ? 151.422 157.263 151.895 1.00 20.75  ? 109  SER A CB  1 
ATOM   734  O  OG  . SER A 1 144 ? 151.618 155.884 152.148 1.00 20.75  ? 109  SER A OG  1 
ATOM   735  N  N   . SER A 1 145 ? 151.828 155.581 149.074 1.00 18.91  ? 110  SER A N   1 
ATOM   736  C  CA  . SER A 1 145 ? 152.749 154.761 148.295 1.00 18.91  ? 110  SER A CA  1 
ATOM   737  C  C   . SER A 1 145 ? 152.572 154.916 146.789 1.00 18.91  ? 110  SER A C   1 
ATOM   738  O  O   . SER A 1 145 ? 153.200 154.177 146.025 1.00 18.91  ? 110  SER A O   1 
ATOM   739  C  CB  . SER A 1 145 ? 152.590 153.291 148.680 1.00 18.91  ? 110  SER A CB  1 
ATOM   740  O  OG  . SER A 1 145 ? 152.977 153.076 150.025 1.00 18.91  ? 110  SER A OG  1 
ATOM   741  N  N   . ALA A 1 146 ? 151.697 155.819 146.355 1.00 16.85  ? 111  ALA A N   1 
ATOM   742  C  CA  . ALA A 1 146 ? 151.526 156.100 144.928 1.00 16.85  ? 111  ALA A CA  1 
ATOM   743  C  C   . ALA A 1 146 ? 152.796 156.445 144.139 1.00 16.85  ? 111  ALA A C   1 
ATOM   744  O  O   . ALA A 1 146 ? 152.888 156.002 142.980 1.00 16.85  ? 111  ALA A O   1 
ATOM   745  C  CB  . ALA A 1 146 ? 150.494 157.223 144.752 1.00 16.85  ? 111  ALA A CB  1 
ATOM   746  N  N   . PRO A 1 147 ? 153.755 157.252 144.635 1.00 16.67  ? 112  PRO A N   1 
ATOM   747  C  CA  . PRO A 1 147 ? 154.910 157.597 143.776 1.00 16.67  ? 112  PRO A CA  1 
ATOM   748  C  C   . PRO A 1 147 ? 155.732 156.412 143.289 1.00 16.67  ? 112  PRO A C   1 
ATOM   749  O  O   . PRO A 1 147 ? 156.164 156.413 142.133 1.00 16.67  ? 112  PRO A O   1 
ATOM   750  C  CB  . PRO A 1 147 ? 155.736 158.528 144.673 1.00 16.67  ? 112  PRO A CB  1 
ATOM   751  C  CG  . PRO A 1 147 ? 154.754 159.151 145.547 1.00 16.67  ? 112  PRO A CG  1 
ATOM   752  C  CD  . PRO A 1 147 ? 153.785 158.058 145.872 1.00 16.67  ? 112  PRO A CD  1 
ATOM   753  N  N   . GLU A 1 148 ? 155.964 155.399 144.128 1.00 17.28  ? 113  GLU A N   1 
ATOM   754  C  CA  . GLU A 1 148 ? 156.754 154.253 143.686 1.00 17.28  ? 113  GLU A CA  1 
ATOM   755  C  C   . GLU A 1 148 ? 156.015 153.435 142.635 1.00 17.28  ? 113  GLU A C   1 
ATOM   756  O  O   . GLU A 1 148 ? 156.626 152.953 141.674 1.00 17.28  ? 113  GLU A O   1 
ATOM   757  C  CB  . GLU A 1 148 ? 157.129 153.388 144.883 1.00 17.28  ? 113  GLU A CB  1 
ATOM   758  C  CG  . GLU A 1 148 ? 158.067 154.077 145.840 1.00 17.28  ? 113  GLU A CG  1 
ATOM   759  C  CD  . GLU A 1 148 ? 157.702 153.824 147.279 1.00 17.28  ? 113  GLU A CD  1 
ATOM   760  O  OE1 . GLU A 1 148 ? 157.167 152.737 147.569 1.00 17.28  ? 113  GLU A OE1 1 
ATOM   761  O  OE2 . GLU A 1 148 ? 157.940 154.713 148.121 1.00 17.28  ? 113  GLU A OE2 1 
ATOM   762  N  N   . ILE A 1 149 ? 154.701 153.280 142.792 1.00 17.17  ? 114  ILE A N   1 
ATOM   763  C  CA  . ILE A 1 149 ? 153.906 152.565 141.801 1.00 17.17  ? 114  ILE A CA  1 
ATOM   764  C  C   . ILE A 1 149 ? 153.917 153.301 140.470 1.00 17.17  ? 114  ILE A C   1 
ATOM   765  O  O   . ILE A 1 149 ? 154.085 152.689 139.406 1.00 17.17  ? 114  ILE A O   1 
ATOM   766  C  CB  . ILE A 1 149 ? 152.474 152.370 142.326 1.00 17.17  ? 114  ILE A CB  1 
ATOM   767  C  CG1 . ILE A 1 149 ? 152.499 151.750 143.722 1.00 17.17  ? 114  ILE A CG1 1 
ATOM   768  C  CG2 . ILE A 1 149 ? 151.652 151.557 141.348 1.00 17.17  ? 114  ILE A CG2 1 
ATOM   769  C  CD1 . ILE A 1 149 ? 151.203 151.896 144.463 1.00 17.17  ? 114  ILE A CD1 1 
ATOM   770  N  N   . LEU A 1 150 ? 153.771 154.626 140.505 1.00 17.09  ? 115  LEU A N   1 
ATOM   771  C  CA  . LEU A 1 150 ? 153.787 155.370 139.254 1.00 17.09  ? 115  LEU A CA  1 
ATOM   772  C  C   . LEU A 1 150 ? 155.176 155.392 138.632 1.00 17.09  ? 115  LEU A C   1 
ATOM   773  O  O   . LEU A 1 150 ? 155.293 155.378 137.403 1.00 17.09  ? 115  LEU A O   1 
ATOM   774  C  CB  . LEU A 1 150 ? 153.270 156.789 139.475 1.00 17.09  ? 115  LEU A CB  1 
ATOM   775  C  CG  . LEU A 1 150 ? 151.743 156.880 139.468 1.00 17.09  ? 115  LEU A CG  1 
ATOM   776  C  CD1 . LEU A 1 150 ? 151.274 158.283 139.798 1.00 17.09  ? 115  LEU A CD1 1 
ATOM   777  C  CD2 . LEU A 1 150 ? 151.187 156.420 138.140 1.00 17.09  ? 115  LEU A CD2 1 
ATOM   778  N  N   . LEU A 1 151 ? 156.229 155.386 139.454 1.00 16.35  ? 116  LEU A N   1 
ATOM   779  C  CA  . LEU A 1 151 ? 157.584 155.277 138.925 1.00 16.35  ? 116  LEU A CA  1 
ATOM   780  C  C   . LEU A 1 151 ? 157.795 153.948 138.218 1.00 16.35  ? 116  LEU A C   1 
ATOM   781  O  O   . LEU A 1 151 ? 158.374 153.908 137.129 1.00 16.35  ? 116  LEU A O   1 
ATOM   782  C  CB  . LEU A 1 151 ? 158.606 155.443 140.047 1.00 16.35  ? 116  LEU A CB  1 
ATOM   783  C  CG  . LEU A 1 151 ? 160.082 155.257 139.695 1.00 16.35  ? 116  LEU A CG  1 
ATOM   784  C  CD1 . LEU A 1 151 ? 160.491 156.136 138.530 1.00 16.35  ? 116  LEU A CD1 1 
ATOM   785  C  CD2 . LEU A 1 151 ? 160.922 155.565 140.909 1.00 16.35  ? 116  LEU A CD2 1 
ATOM   786  N  N   . SER A 1 152 ? 157.328 152.851 138.819 1.00 18.49  ? 117  SER A N   1 
ATOM   787  C  CA  . SER A 1 152 ? 157.473 151.546 138.180 1.00 18.49  ? 117  SER A CA  1 
ATOM   788  C  C   . SER A 1 152 ? 156.706 151.483 136.863 1.00 18.49  ? 117  SER A C   1 
ATOM   789  O  O   . SER A 1 152 ? 157.236 151.010 135.848 1.00 18.49  ? 117  SER A O   1 
ATOM   790  C  CB  . SER A 1 152 ? 157.003 150.445 139.127 1.00 18.49  ? 117  SER A CB  1 
ATOM   791  O  OG  . SER A 1 152 ? 157.069 149.178 138.502 1.00 18.49  ? 117  SER A OG  1 
ATOM   792  N  N   . VAL A 1 153 ? 155.466 151.983 136.855 1.00 20.76  ? 118  VAL A N   1 
ATOM   793  C  CA  . VAL A 1 153 ? 154.649 151.944 135.643 1.00 20.76  ? 118  VAL A CA  1 
ATOM   794  C  C   . VAL A 1 153 ? 155.269 152.793 134.537 1.00 20.76  ? 118  VAL A C   1 
ATOM   795  O  O   . VAL A 1 153 ? 155.346 152.363 133.380 1.00 20.76  ? 118  VAL A O   1 
ATOM   796  C  CB  . VAL A 1 153 ? 153.212 152.391 135.959 1.00 20.76  ? 118  VAL A CB  1 
ATOM   797  C  CG1 . VAL A 1 153 ? 152.414 152.547 134.684 1.00 20.76  ? 118  VAL A CG1 1 
ATOM   798  C  CG2 . VAL A 1 153 ? 152.547 151.395 136.879 1.00 20.76  ? 118  VAL A CG2 1 
ATOM   799  N  N   . ILE A 1 154 ? 155.729 154.001 134.871 1.00 22.28  ? 119  ILE A N   1 
ATOM   800  C  CA  . ILE A 1 154 ? 156.310 154.886 133.866 1.00 22.28  ? 119  ILE A CA  1 
ATOM   801  C  C   . ILE A 1 154 ? 157.651 154.345 133.376 1.00 22.28  ? 119  ILE A C   1 
ATOM   802  O  O   . ILE A 1 154 ? 157.973 154.440 132.186 1.00 22.28  ? 119  ILE A O   1 
ATOM   803  C  CB  . ILE A 1 154 ? 156.420 156.313 134.432 1.00 22.28  ? 119  ILE A CB  1 
ATOM   804  C  CG1 . ILE A 1 154 ? 155.024 156.927 134.542 1.00 22.28  ? 119  ILE A CG1 1 
ATOM   805  C  CG2 . ILE A 1 154 ? 157.302 157.187 133.566 1.00 22.28  ? 119  ILE A CG2 1 
ATOM   806  C  CD1 . ILE A 1 154 ? 155.009 158.335 135.071 1.00 22.28  ? 119  ILE A CD1 1 
ATOM   807  N  N   . GLU A 1 155 ? 158.443 153.747 134.271 1.00 25.64  ? 120  GLU A N   1 
ATOM   808  C  CA  . GLU A 1 155 ? 159.711 153.150 133.865 1.00 25.64  ? 120  GLU A CA  1 
ATOM   809  C  C   . GLU A 1 155 ? 159.498 151.996 132.896 1.00 25.64  ? 120  GLU A C   1 
ATOM   810  O  O   . GLU A 1 155 ? 160.244 151.852 131.921 1.00 25.64  ? 120  GLU A O   1 
ATOM   811  C  CB  . GLU A 1 155 ? 160.484 152.676 135.095 1.00 25.64  ? 120  GLU A CB  1 
ATOM   812  C  CG  . GLU A 1 155 ? 161.887 152.174 134.801 1.00 25.64  ? 120  GLU A CG  1 
ATOM   813  C  CD  . GLU A 1 155 ? 162.851 153.293 134.470 1.00 25.64  ? 120  GLU A CD  1 
ATOM   814  O  OE1 . GLU A 1 155 ? 162.735 154.377 135.076 1.00 25.64  ? 120  GLU A OE1 1 
ATOM   815  O  OE2 . GLU A 1 155 ? 163.729 153.087 133.607 1.00 25.64  ? 120  GLU A OE2 1 
ATOM   816  N  N   . VAL A 1 156 ? 158.494 151.155 133.150 1.00 27.37  ? 121  VAL A N   1 
ATOM   817  C  CA  . VAL A 1 156 ? 158.216 150.058 132.226 1.00 27.37  ? 121  VAL A CA  1 
ATOM   818  C  C   . VAL A 1 156 ? 157.679 150.589 130.900 1.00 27.37  ? 121  VAL A C   1 
ATOM   819  O  O   . VAL A 1 156 ? 158.151 150.201 129.826 1.00 27.37  ? 121  VAL A O   1 
ATOM   820  C  CB  . VAL A 1 156 ? 157.256 149.043 132.867 1.00 27.37  ? 121  VAL A CB  1 
ATOM   821  C  CG1 . VAL A 1 156 ? 156.716 148.088 131.823 1.00 27.37  ? 121  VAL A CG1 1 
ATOM   822  C  CG2 . VAL A 1 156 ? 157.991 148.267 133.933 1.00 27.37  ? 121  VAL A CG2 1 
ATOM   823  N  N   . CYS A 1 157 ? 156.703 151.500 130.952 1.00 29.23  ? 122  CYS A N   1 
ATOM   824  C  CA  . CYS A 1 157 ? 156.019 151.915 129.730 1.00 29.23  ? 122  CYS A CA  1 
ATOM   825  C  C   . CYS A 1 157 ? 156.891 152.795 128.841 1.00 29.23  ? 122  CYS A C   1 
ATOM   826  O  O   . CYS A 1 157 ? 156.750 152.756 127.614 1.00 29.23  ? 122  CYS A O   1 
ATOM   827  C  CB  . CYS A 1 157 ? 154.721 152.641 130.077 1.00 29.23  ? 122  CYS A CB  1 
ATOM   828  S  SG  . CYS A 1 157 ? 153.411 151.552 130.671 1.00 29.23  ? 122  CYS A SG  1 
ATOM   829  N  N   . GLY A 1 158 ? 157.775 153.601 129.430 1.00 34.31  ? 123  GLY A N   1 
ATOM   830  C  CA  . GLY A 1 158 ? 158.571 154.517 128.630 1.00 34.31  ? 123  GLY A CA  1 
ATOM   831  C  C   . GLY A 1 158 ? 159.582 153.826 127.734 1.00 34.31  ? 123  GLY A C   1 
ATOM   832  O  O   . GLY A 1 158 ? 159.730 154.183 126.562 1.00 34.31  ? 123  GLY A O   1 
ATOM   833  N  N   . HIS A 1 159 ? 160.288 152.834 128.263 1.00 42.43  ? 124  HIS A N   1 
ATOM   834  C  CA  . HIS A 1 159 ? 161.432 152.243 127.566 1.00 42.43  ? 124  HIS A CA  1 
ATOM   835  C  C   . HIS A 1 159 ? 161.039 151.016 126.750 1.00 42.43  ? 124  HIS A C   1 
ATOM   836  O  O   . HIS A 1 159 ? 161.650 149.954 126.874 1.00 42.43  ? 124  HIS A O   1 
ATOM   837  C  CB  . HIS A 1 159 ? 162.527 151.905 128.570 1.00 42.43  ? 124  HIS A CB  1 
ATOM   838  C  CG  . HIS A 1 159 ? 163.082 153.104 129.273 1.00 42.43  ? 124  HIS A CG  1 
ATOM   839  N  ND1 . HIS A 1 159 ? 164.171 153.805 128.804 1.00 42.43  ? 124  HIS A ND1 1 
ATOM   840  C  CD2 . HIS A 1 159 ? 162.695 153.726 130.410 1.00 42.43  ? 124  HIS A CD2 1 
ATOM   841  C  CE1 . HIS A 1 159 ? 164.428 154.811 129.620 1.00 42.43  ? 124  HIS A CE1 1 
ATOM   842  N  NE2 . HIS A 1 159 ? 163.549 154.784 130.604 1.00 42.43  ? 124  HIS A NE2 1 
ATOM   843  N  N   . ASN A 1 160 ? 160.024 151.173 125.894 1.00 51.67  ? 125  ASN A N   1 
ATOM   844  C  CA  . ASN A 1 160 ? 159.577 150.139 124.951 1.00 51.67  ? 125  ASN A CA  1 
ATOM   845  C  C   . ASN A 1 160 ? 159.254 148.822 125.660 1.00 51.67  ? 125  ASN A C   1 
ATOM   846  O  O   . ASN A 1 160 ? 159.603 147.736 125.190 1.00 51.67  ? 125  ASN A O   1 
ATOM   847  C  CB  . ASN A 1 160 ? 160.608 149.927 123.838 1.00 51.67  ? 125  ASN A CB  1 
ATOM   848  C  CG  . ASN A 1 160 ? 160.031 149.200 122.634 1.00 51.67  ? 125  ASN A CG  1 
ATOM   849  O  OD1 . ASN A 1 160 ? 159.006 149.602 122.085 1.00 51.67  ? 125  ASN A OD1 1 
ATOM   850  N  ND2 . ASN A 1 160 ? 160.684 148.118 122.228 1.00 51.67  ? 125  ASN A ND2 1 
ATOM   851  N  N   . PHE A 1 161 ? 158.606 148.931 126.822 1.00 45.37  ? 126  PHE A N   1 
ATOM   852  C  CA  . PHE A 1 161 ? 158.093 147.788 127.581 1.00 45.37  ? 126  PHE A CA  1 
ATOM   853  C  C   . PHE A 1 161 ? 159.198 146.813 127.979 1.00 45.37  ? 126  PHE A C   1 
ATOM   854  O  O   . PHE A 1 161 ? 158.952 145.617 128.144 1.00 45.37  ? 126  PHE A O   1 
ATOM   855  C  CB  . PHE A 1 161 ? 156.994 147.053 126.808 1.00 45.37  ? 126  PHE A CB  1 
ATOM   856  C  CG  . PHE A 1 161 ? 155.749 147.864 126.604 1.00 45.37  ? 126  PHE A CG  1 
ATOM   857  C  CD1 . PHE A 1 161 ? 155.687 148.825 125.609 1.00 45.37  ? 126  PHE A CD1 1 
ATOM   858  C  CD2 . PHE A 1 161 ? 154.639 147.665 127.404 1.00 45.37  ? 126  PHE A CD2 1 
ATOM   859  C  CE1 . PHE A 1 161 ? 154.544 149.572 125.418 1.00 45.37  ? 126  PHE A CE1 1 
ATOM   860  C  CE2 . PHE A 1 161 ? 153.494 148.409 127.215 1.00 45.37  ? 126  PHE A CE2 1 
ATOM   861  C  CZ  . PHE A 1 161 ? 153.446 149.363 126.222 1.00 45.37  ? 126  PHE A CZ  1 
ATOM   862  N  N   . THR A 1 162 ? 160.420 147.309 128.136 1.00 51.63  ? 127  THR A N   1 
ATOM   863  C  CA  . THR A 1 162 ? 161.552 146.499 128.565 1.00 51.63  ? 127  THR A CA  1 
ATOM   864  C  C   . THR A 1 162 ? 161.878 146.848 130.009 1.00 51.63  ? 127  THR A C   1 
ATOM   865  O  O   . THR A 1 162 ? 162.086 148.022 130.334 1.00 51.63  ? 127  THR A O   1 
ATOM   866  C  CB  . THR A 1 162 ? 162.771 146.729 127.667 1.00 51.63  ? 127  THR A CB  1 
ATOM   867  O  OG1 . THR A 1 162 ? 162.573 146.064 126.413 1.00 51.63  ? 127  THR A OG1 1 
ATOM   868  C  CG2 . THR A 1 162 ? 164.033 146.186 128.321 1.00 51.63  ? 127  THR A CG2 1 
ATOM   869  N  N   . ALA A 1 163 ? 161.908 145.833 130.868 1.00 45.24  ? 128  ALA A N   1 
ATOM   870  C  CA  . ALA A 1 163 ? 162.077 146.064 132.296 1.00 45.24  ? 128  ALA A CA  1 
ATOM   871  C  C   . ALA A 1 163 ? 163.462 146.613 132.603 1.00 45.24  ? 128  ALA A C   1 
ATOM   872  O  O   . ALA A 1 163 ? 164.474 146.088 132.132 1.00 45.24  ? 128  ALA A O   1 
ATOM   873  C  CB  . ALA A 1 163 ? 161.842 144.768 133.069 1.00 45.24  ? 128  ALA A CB  1 
ATOM   874  N  N   . GLY A 1 164 ? 163.499 147.680 133.396 1.00 41.17  ? 129  GLY A N   1 
ATOM   875  C  CA  . GLY A 1 164 ? 164.738 148.250 133.866 1.00 41.17  ? 129  GLY A CA  1 
ATOM   876  C  C   . GLY A 1 164 ? 164.989 147.901 135.320 1.00 41.17  ? 129  GLY A C   1 
ATOM   877  O  O   . GLY A 1 164 ? 164.104 147.428 136.027 1.00 41.17  ? 129  GLY A O   1 
ATOM   878  N  N   . ASP A 1 165 ? 166.228 148.129 135.757 1.00 38.46  ? 130  ASP A N   1 
ATOM   879  C  CA  . ASP A 1 165 ? 166.581 147.849 137.144 1.00 38.46  ? 130  ASP A CA  1 
ATOM   880  C  C   . ASP A 1 165 ? 165.901 148.817 138.103 1.00 38.46  ? 130  ASP A C   1 
ATOM   881  O  O   . ASP A 1 165 ? 165.560 148.436 139.231 1.00 38.46  ? 130  ASP A O   1 
ATOM   882  C  CB  . ASP A 1 165 ? 168.098 147.911 137.316 1.00 38.46  ? 130  ASP A CB  1 
ATOM   883  C  CG  . ASP A 1 165 ? 168.784 146.614 136.928 1.00 38.46  ? 130  ASP A CG  1 
ATOM   884  O  OD1 . ASP A 1 165 ? 168.208 145.535 137.179 1.00 38.46  ? 130  ASP A OD1 1 
ATOM   885  O  OD2 . ASP A 1 165 ? 169.900 146.675 136.369 1.00 38.46  ? 130  ASP A OD2 1 
ATOM   886  N  N   . LEU A 1 166 ? 165.685 150.061 137.659 1.00 28.11  ? 131  LEU A N   1 
ATOM   887  C  CA  . LEU A 1 166 ? 165.238 151.134 138.544 1.00 28.11  ? 131  LEU A CA  1 
ATOM   888  C  C   . LEU A 1 166 ? 163.870 150.839 139.144 1.00 28.11  ? 131  LEU A C   1 
ATOM   889  O  O   . LEU A 1 166 ? 163.670 150.994 140.353 1.00 28.11  ? 131  LEU A O   1 
ATOM   890  C  CB  . LEU A 1 166 ? 165.207 152.452 137.773 1.00 28.11  ? 131  LEU A CB  1 
ATOM   891  C  CG  . LEU A 1 166 ? 165.063 153.762 138.544 1.00 28.11  ? 131  LEU A CG  1 
ATOM   892  C  CD1 . LEU A 1 166 ? 166.118 153.887 139.614 1.00 28.11  ? 131  LEU A CD1 1 
ATOM   893  C  CD2 . LEU A 1 166 ? 165.139 154.926 137.583 1.00 28.11  ? 131  LEU A CD2 1 
ATOM   894  N  N   . GLY A 1 167 ? 162.924 150.397 138.316 1.00 25.84  ? 132  GLY A N   1 
ATOM   895  C  CA  . GLY A 1 167 ? 161.557 150.173 138.730 1.00 25.84  ? 132  GLY A CA  1 
ATOM   896  C  C   . GLY A 1 167 ? 161.397 149.236 139.912 1.00 25.84  ? 132  GLY A C   1 
ATOM   897  O  O   . GLY A 1 167 ? 160.973 149.645 140.996 1.00 25.84  ? 132  GLY A O   1 
ATOM   898  N  N   . PRO A 1 168 ? 161.713 147.953 139.723 1.00 25.39  ? 133  PRO A N   1 
ATOM   899  C  CA  . PRO A 1 168 ? 161.650 147.018 140.857 1.00 25.39  ? 133  PRO A CA  1 
ATOM   900  C  C   . PRO A 1 168 ? 162.695 147.283 141.929 1.00 25.39  ? 133  PRO A C   1 
ATOM   901  O  O   . PRO A 1 168 ? 162.443 146.990 143.111 1.00 25.39  ? 133  PRO A O   1 
ATOM   902  C  CB  . PRO A 1 168 ? 161.861 145.653 140.191 1.00 25.39  ? 133  PRO A CB  1 
ATOM   903  C  CG  . PRO A 1 168 ? 161.437 145.860 138.780 1.00 25.39  ? 133  PRO A CG  1 
ATOM   904  C  CD  . PRO A 1 168 ? 161.873 147.247 138.443 1.00 25.39  ? 133  PRO A CD  1 
ATOM   905  N  N   . SER A 1 169 ? 163.861 147.826 141.564 1.00 23.31  ? 134  SER A N   1 
ATOM   906  C  CA  . SER A 1 169 ? 164.907 148.000 142.561 1.00 23.31  ? 134  SER A CA  1 
ATOM   907  C  C   . SER A 1 169 ? 164.559 149.093 143.563 1.00 23.31  ? 134  SER A C   1 
ATOM   908  O  O   . SER A 1 169 ? 164.855 148.947 144.754 1.00 23.31  ? 134  SER A O   1 
ATOM   909  C  CB  . SER A 1 169 ? 166.238 148.300 141.877 1.00 23.31  ? 134  SER A CB  1 
ATOM   910  O  OG  . SER A 1 169 ? 167.253 148.517 142.836 1.00 23.31  ? 134  SER A OG  1 
ATOM   911  N  N   . THR A 1 170 ? 163.891 150.167 143.122 1.00 20.13  ? 135  THR A N   1 
ATOM   912  C  CA  . THR A 1 170 ? 163.472 151.186 144.077 1.00 20.13  ? 135  THR A CA  1 
ATOM   913  C  C   . THR A 1 170 ? 162.333 150.689 144.956 1.00 20.13  ? 135  THR A C   1 
ATOM   914  O  O   . THR A 1 170 ? 162.220 151.114 146.107 1.00 20.13  ? 135  THR A O   1 
ATOM   915  C  CB  . THR A 1 170 ? 163.079 152.488 143.371 1.00 20.13  ? 135  THR A CB  1 
ATOM   916  O  OG1 . THR A 1 170 ? 162.900 153.517 144.352 1.00 20.13  ? 135  THR A OG1 1 
ATOM   917  C  CG2 . THR A 1 170 ? 161.788 152.344 142.595 1.00 20.13  ? 135  THR A CG2 1 
ATOM   918  N  N   . ILE A 1 171 ? 161.510 149.765 144.458 1.00 18.58  ? 136  ILE A N   1 
ATOM   919  C  CA  . ILE A 1 171 ? 160.455 149.193 145.287 1.00 18.58  ? 136  ILE A CA  1 
ATOM   920  C  C   . ILE A 1 171 ? 161.057 148.336 146.394 1.00 18.58  ? 136  ILE A C   1 
ATOM   921  O  O   . ILE A 1 171 ? 160.660 148.438 147.559 1.00 18.58  ? 136  ILE A O   1 
ATOM   922  C  CB  . ILE A 1 171 ? 159.460 148.405 144.418 1.00 18.58  ? 136  ILE A CB  1 
ATOM   923  C  CG1 . ILE A 1 171 ? 158.578 149.374 143.632 1.00 18.58  ? 136  ILE A CG1 1 
ATOM   924  C  CG2 . ILE A 1 171 ? 158.605 147.497 145.267 1.00 18.58  ? 136  ILE A CG2 1 
ATOM   925  C  CD1 . ILE A 1 171 ? 157.692 148.709 142.614 1.00 18.58  ? 136  ILE A CD1 1 
ATOM   926  N  N   . VAL A 1 172 ? 162.045 147.503 146.059 1.00 19.01  ? 137  VAL A N   1 
ATOM   927  C  CA  . VAL A 1 172 ? 162.672 146.675 147.093 1.00 19.01  ? 137  VAL A CA  1 
ATOM   928  C  C   . VAL A 1 172 ? 163.470 147.538 148.075 1.00 19.01  ? 137  VAL A C   1 
ATOM   929  O  O   . VAL A 1 172 ? 163.463 147.293 149.296 1.00 19.01  ? 137  VAL A O   1 
ATOM   930  C  CB  . VAL A 1 172 ? 163.538 145.579 146.447 1.00 19.01  ? 137  VAL A CB  1 
ATOM   931  C  CG1 . VAL A 1 172 ? 164.258 144.770 147.508 1.00 19.01  ? 137  VAL A CG1 1 
ATOM   932  C  CG2 . VAL A 1 172 ? 162.677 144.667 145.595 1.00 19.01  ? 137  VAL A CG2 1 
ATOM   933  N  N   . GLY A 1 173 ? 164.142 148.578 147.572 1.00 19.97  ? 138  GLY A N   1 
ATOM   934  C  CA  . GLY A 1 173 ? 164.859 149.476 148.462 1.00 19.97  ? 138  GLY A CA  1 
ATOM   935  C  C   . GLY A 1 173 ? 163.936 150.234 149.395 1.00 19.97  ? 138  GLY A C   1 
ATOM   936  O  O   . GLY A 1 173 ? 164.224 150.375 150.588 1.00 19.97  ? 138  GLY A O   1 
ATOM   937  N  N   . SER A 1 174 ? 162.804 150.715 148.875 1.00 19.14  ? 139  SER A N   1 
ATOM   938  C  CA  . SER A 1 174 ? 161.803 151.349 149.717 1.00 19.14  ? 139  SER A CA  1 
ATOM   939  C  C   . SER A 1 174 ? 161.174 150.368 150.687 1.00 19.14  ? 139  SER A C   1 
ATOM   940  O  O   . SER A 1 174 ? 160.768 150.779 151.773 1.00 19.14  ? 139  SER A O   1 
ATOM   941  C  CB  . SER A 1 174 ? 160.715 151.989 148.861 1.00 19.14  ? 139  SER A CB  1 
ATOM   942  O  OG  . SER A 1 174 ? 161.238 153.051 148.087 1.00 19.14  ? 139  SER A OG  1 
ATOM   943  N  N   . ALA A 1 175 ? 161.099 149.087 150.327 1.00 20.50  ? 140  ALA A N   1 
ATOM   944  C  CA  . ALA A 1 175 ? 160.627 148.077 151.268 1.00 20.50  ? 140  ALA A CA  1 
ATOM   945  C  C   . ALA A 1 175 ? 161.547 147.977 152.472 1.00 20.50  ? 140  ALA A C   1 
ATOM   946  O  O   . ALA A 1 175 ? 161.091 148.004 153.623 1.00 20.50  ? 140  ALA A O   1 
ATOM   947  C  CB  . ALA A 1 175 ? 160.531 146.724 150.579 1.00 20.50  ? 140  ALA A CB  1 
ATOM   948  N  N   . ALA A 1 176 ? 162.851 147.851 152.221 1.00 20.77  ? 141  ALA A N   1 
ATOM   949  C  CA  . ALA A 1 176 ? 163.794 147.761 153.335 1.00 20.77  ? 141  ALA A CA  1 
ATOM   950  C  C   . ALA A 1 176 ? 163.812 149.046 154.153 1.00 20.77  ? 141  ALA A C   1 
ATOM   951  O  O   . ALA A 1 176 ? 163.845 149.001 155.391 1.00 20.77  ? 141  ALA A O   1 
ATOM   952  C  CB  . ALA A 1 176 ? 165.191 147.435 152.824 1.00 20.77  ? 141  ALA A CB  1 
ATOM   953  N  N   . PHE A 1 177 ? 163.773 150.199 153.479 1.00 20.79  ? 142  PHE A N   1 
ATOM   954  C  CA  . PHE A 1 177 ? 163.733 151.480 154.179 1.00 20.79  ? 142  PHE A CA  1 
ATOM   955  C  C   . PHE A 1 177 ? 162.496 151.584 155.062 1.00 20.79  ? 142  PHE A C   1 
ATOM   956  O  O   . PHE A 1 177 ? 162.593 151.944 156.241 1.00 20.79  ? 142  PHE A O   1 
ATOM   957  C  CB  . PHE A 1 177 ? 163.770 152.618 153.162 1.00 20.79  ? 142  PHE A CB  1 
ATOM   958  C  CG  . PHE A 1 177 ? 163.626 153.984 153.762 1.00 20.79  ? 142  PHE A CG  1 
ATOM   959  C  CD1 . PHE A 1 177 ? 164.706 154.615 154.342 1.00 20.79  ? 142  PHE A CD1 1 
ATOM   960  C  CD2 . PHE A 1 177 ? 162.411 154.643 153.732 1.00 20.79  ? 142  PHE A CD2 1 
ATOM   961  C  CE1 . PHE A 1 177 ? 164.578 155.875 154.881 1.00 20.79  ? 142  PHE A CE1 1 
ATOM   962  C  CE2 . PHE A 1 177 ? 162.277 155.901 154.276 1.00 20.79  ? 142  PHE A CE2 1 
ATOM   963  C  CZ  . PHE A 1 177 ? 163.361 156.516 154.853 1.00 20.79  ? 142  PHE A CZ  1 
ATOM   964  N  N   . ASN A 1 178 ? 161.330 151.230 154.512 1.00 20.42  ? 143  ASN A N   1 
ATOM   965  C  CA  . ASN A 1 178 ? 160.074 151.289 155.249 1.00 20.42  ? 143  ASN A CA  1 
ATOM   966  C  C   . ASN A 1 178 ? 160.114 150.376 156.463 1.00 20.42  ? 143  ASN A C   1 
ATOM   967  O  O   . ASN A 1 178 ? 159.704 150.765 157.562 1.00 20.42  ? 143  ASN A O   1 
ATOM   968  C  CB  . ASN A 1 178 ? 158.922 150.883 154.328 1.00 20.42  ? 143  ASN A CB  1 
ATOM   969  C  CG  . ASN A 1 178 ? 158.421 152.022 153.468 1.00 20.42  ? 143  ASN A CG  1 
ATOM   970  O  OD1 . ASN A 1 178 ? 158.379 153.167 153.896 1.00 20.42  ? 143  ASN A OD1 1 
ATOM   971  N  ND2 . ASN A 1 178 ? 158.040 151.706 152.239 1.00 20.42  ? 143  ASN A ND2 1 
ATOM   972  N  N   . MET A 1 179 ? 160.617 149.153 156.284 1.00 24.41  ? 144  MET A N   1 
ATOM   973  C  CA  . MET A 1 179 ? 160.617 148.196 157.382 1.00 24.41  ? 144  MET A CA  1 
ATOM   974  C  C   . MET A 1 179 ? 161.593 148.585 158.486 1.00 24.41  ? 144  MET A C   1 
ATOM   975  O  O   . MET A 1 179 ? 161.323 148.314 159.660 1.00 24.41  ? 144  MET A O   1 
ATOM   976  C  CB  . MET A 1 179 ? 160.937 146.794 156.863 1.00 24.41  ? 144  MET A CB  1 
ATOM   977  C  CG  . MET A 1 179 ? 160.612 145.679 157.847 1.00 24.41  ? 144  MET A CG  1 
ATOM   978  S  SD  . MET A 1 179 ? 158.861 145.270 157.966 1.00 24.41  ? 144  MET A SD  1 
ATOM   979  C  CE  . MET A 1 179 ? 158.528 144.710 156.300 1.00 24.41  ? 144  MET A CE  1 
ATOM   980  N  N   . PHE A 1 180 ? 162.729 149.202 158.155 1.00 24.54  ? 145  PHE A N   1 
ATOM   981  C  CA  . PHE A 1 180 ? 163.739 149.442 159.184 1.00 24.54  ? 145  PHE A CA  1 
ATOM   982  C  C   . PHE A 1 180 ? 163.761 150.881 159.692 1.00 24.54  ? 145  PHE A C   1 
ATOM   983  O  O   . PHE A 1 180 ? 163.560 151.114 160.889 1.00 24.54  ? 145  PHE A O   1 
ATOM   984  C  CB  . PHE A 1 180 ? 165.123 149.029 158.665 1.00 24.54  ? 145  PHE A CB  1 
ATOM   985  C  CG  . PHE A 1 180 ? 165.162 147.636 158.104 1.00 24.54  ? 145  PHE A CG  1 
ATOM   986  C  CD1 . PHE A 1 180 ? 164.428 146.617 158.689 1.00 24.54  ? 145  PHE A CD1 1 
ATOM   987  C  CD2 . PHE A 1 180 ? 165.927 147.346 156.989 1.00 24.54  ? 145  PHE A CD2 1 
ATOM   988  C  CE1 . PHE A 1 180 ? 164.453 145.341 158.169 1.00 24.54  ? 145  PHE A CE1 1 
ATOM   989  C  CE2 . PHE A 1 180 ? 165.954 146.072 156.467 1.00 24.54  ? 145  PHE A CE2 1 
ATOM   990  C  CZ  . PHE A 1 180 ? 165.215 145.072 157.058 1.00 24.54  ? 145  PHE A CZ  1 
ATOM   991  N  N   . ILE A 1 181 ? 163.996 151.855 158.808 1.00 20.84  ? 146  ILE A N   1 
ATOM   992  C  CA  . ILE A 1 181 ? 164.288 153.206 159.281 1.00 20.84  ? 146  ILE A CA  1 
ATOM   993  C  C   . ILE A 1 181 ? 163.034 153.862 159.848 1.00 20.84  ? 146  ILE A C   1 
ATOM   994  O  O   . ILE A 1 181 ? 163.082 154.530 160.889 1.00 20.84  ? 146  ILE A O   1 
ATOM   995  C  CB  . ILE A 1 181 ? 164.914 154.042 158.150 1.00 20.84  ? 146  ILE A CB  1 
ATOM   996  C  CG1 . ILE A 1 181 ? 166.419 153.787 158.085 1.00 20.84  ? 146  ILE A CG1 1 
ATOM   997  C  CG2 . ILE A 1 181 ? 164.658 155.526 158.360 1.00 20.84  ? 146  ILE A CG2 1 
ATOM   998  C  CD1 . ILE A 1 181 ? 167.214 154.510 159.145 1.00 20.84  ? 146  ILE A CD1 1 
ATOM   999  N  N   . ILE A 1 182 ? 161.890 153.666 159.192 1.00 21.89  ? 147  ILE A N   1 
ATOM   1000 C  CA  . ILE A 1 182 ? 160.653 154.280 159.662 1.00 21.89  ? 147  ILE A CA  1 
ATOM   1001 C  C   . ILE A 1 182 ? 160.211 153.657 160.980 1.00 21.89  ? 147  ILE A C   1 
ATOM   1002 O  O   . ILE A 1 182 ? 159.714 154.352 161.873 1.00 21.89  ? 147  ILE A O   1 
ATOM   1003 C  CB  . ILE A 1 182 ? 159.566 154.180 158.578 1.00 21.89  ? 147  ILE A CB  1 
ATOM   1004 C  CG1 . ILE A 1 182 ? 159.870 155.166 157.457 1.00 21.89  ? 147  ILE A CG1 1 
ATOM   1005 C  CG2 . ILE A 1 182 ? 158.199 154.491 159.138 1.00 21.89  ? 147  ILE A CG2 1 
ATOM   1006 C  CD1 . ILE A 1 182 ? 158.889 155.106 156.333 1.00 21.89  ? 147  ILE A CD1 1 
ATOM   1007 N  N   . ILE A 1 183 ? 160.407 152.347 161.140 1.00 24.86  ? 148  ILE A N   1 
ATOM   1008 C  CA  . ILE A 1 183 ? 160.060 151.707 162.405 1.00 24.86  ? 148  ILE A CA  1 
ATOM   1009 C  C   . ILE A 1 183 ? 160.992 152.178 163.521 1.00 24.86  ? 148  ILE A C   1 
ATOM   1010 O  O   . ILE A 1 183 ? 160.556 152.388 164.658 1.00 24.86  ? 148  ILE A O   1 
ATOM   1011 C  CB  . ILE A 1 183 ? 160.050 150.175 162.245 1.00 24.86  ? 148  ILE A CB  1 
ATOM   1012 C  CG1 . ILE A 1 183 ? 158.723 149.730 161.631 1.00 24.86  ? 148  ILE A CG1 1 
ATOM   1013 C  CG2 . ILE A 1 183 ? 160.253 149.471 163.570 1.00 24.86  ? 148  ILE A CG2 1 
ATOM   1014 C  CD1 . ILE A 1 183 ? 158.612 148.238 161.411 1.00 24.86  ? 148  ILE A CD1 1 
ATOM   1015 N  N   . ALA A 1 184 ? 162.275 152.394 163.212 1.00 26.76  ? 149  ALA A N   1 
ATOM   1016 C  CA  . ALA A 1 184 ? 163.179 152.966 164.209 1.00 26.76  ? 149  ALA A CA  1 
ATOM   1017 C  C   . ALA A 1 184 ? 162.755 154.377 164.605 1.00 26.76  ? 149  ALA A C   1 
ATOM   1018 O  O   . ALA A 1 184 ? 162.795 154.743 165.789 1.00 26.76  ? 149  ALA A O   1 
ATOM   1019 C  CB  . ALA A 1 184 ? 164.611 152.973 163.680 1.00 26.76  ? 149  ALA A CB  1 
ATOM   1020 N  N   . LEU A 1 185 ? 162.349 155.185 163.623 1.00 30.12  ? 150  LEU A N   1 
ATOM   1021 C  CA  . LEU A 1 185 ? 161.871 156.532 163.917 1.00 30.12  ? 150  LEU A CA  1 
ATOM   1022 C  C   . LEU A 1 185 ? 160.610 156.495 164.770 1.00 30.12  ? 150  LEU A C   1 
ATOM   1023 O  O   . LEU A 1 185 ? 160.458 157.294 165.702 1.00 30.12  ? 150  LEU A O   1 
ATOM   1024 C  CB  . LEU A 1 185 ? 161.619 157.296 162.619 1.00 30.12  ? 150  LEU A CB  1 
ATOM   1025 C  CG  . LEU A 1 185 ? 161.046 158.703 162.777 1.00 30.12  ? 150  LEU A CG  1 
ATOM   1026 C  CD1 . LEU A 1 185 ? 161.992 159.569 163.588 1.00 30.12  ? 150  LEU A CD1 1 
ATOM   1027 C  CD2 . LEU A 1 185 ? 160.784 159.324 161.423 1.00 30.12  ? 150  LEU A CD2 1 
ATOM   1028 N  N   . CYS A 1 186 ? 159.696 155.569 164.467 1.00 33.44  ? 151  CYS A N   1 
ATOM   1029 C  CA  . CYS A 1 186 ? 158.490 155.405 165.271 1.00 33.44  ? 151  CYS A CA  1 
ATOM   1030 C  C   . CYS A 1 186 ? 158.817 154.944 166.684 1.00 33.44  ? 151  CYS A C   1 
ATOM   1031 O  O   . CYS A 1 186 ? 158.111 155.302 167.632 1.00 33.44  ? 151  CYS A O   1 
ATOM   1032 C  CB  . CYS A 1 186 ? 157.537 154.419 164.598 1.00 33.44  ? 151  CYS A CB  1 
ATOM   1033 S  SG  . CYS A 1 186 ? 156.513 155.143 163.300 1.00 33.44  ? 151  CYS A SG  1 
ATOM   1034 N  N   . VAL A 1 187 ? 159.866 154.134 166.838 1.00 37.82  ? 152  VAL A N   1 
ATOM   1035 C  CA  . VAL A 1 187 ? 160.338 153.759 168.168 1.00 37.82  ? 152  VAL A CA  1 
ATOM   1036 C  C   . VAL A 1 187 ? 160.797 154.994 168.932 1.00 37.82  ? 152  VAL A C   1 
ATOM   1037 O  O   . VAL A 1 187 ? 160.430 155.199 170.095 1.00 37.82  ? 152  VAL A O   1 
ATOM   1038 C  CB  . VAL A 1 187 ? 161.462 152.710 168.061 1.00 37.82  ? 152  VAL A CB  1 
ATOM   1039 C  CG1 . VAL A 1 187 ? 162.314 152.694 169.320 1.00 37.82  ? 152  VAL A CG1 1 
ATOM   1040 C  CG2 . VAL A 1 187 ? 160.883 151.334 167.804 1.00 37.82  ? 152  VAL A CG2 1 
ATOM   1041 N  N   . TYR A 1 188 ? 161.590 155.845 168.283 1.00 42.45  ? 153  TYR A N   1 
ATOM   1042 C  CA  . TYR A 1 188 ? 162.195 156.955 169.012 1.00 42.45  ? 153  TYR A CA  1 
ATOM   1043 C  C   . TYR A 1 188 ? 161.237 158.122 169.244 1.00 42.45  ? 153  TYR A C   1 
ATOM   1044 O  O   . TYR A 1 188 ? 161.427 158.865 170.213 1.00 42.45  ? 153  TYR A O   1 
ATOM   1045 C  CB  . TYR A 1 188 ? 163.453 157.442 168.281 1.00 42.45  ? 153  TYR A CB  1 
ATOM   1046 C  CG  . TYR A 1 188 ? 164.367 158.321 169.116 1.00 42.45  ? 153  TYR A CG  1 
ATOM   1047 C  CD1 . TYR A 1 188 ? 164.193 159.699 169.180 1.00 42.45  ? 153  TYR A CD1 1 
ATOM   1048 C  CD2 . TYR A 1 188 ? 165.405 157.760 169.848 1.00 42.45  ? 153  TYR A CD2 1 
ATOM   1049 C  CE1 . TYR A 1 188 ? 165.025 160.489 169.949 1.00 42.45  ? 153  TYR A CE1 1 
ATOM   1050 C  CE2 . TYR A 1 188 ? 166.241 158.542 170.615 1.00 42.45  ? 153  TYR A CE2 1 
ATOM   1051 C  CZ  . TYR A 1 188 ? 166.048 159.903 170.662 1.00 42.45  ? 153  TYR A CZ  1 
ATOM   1052 O  OH  . TYR A 1 188 ? 166.884 160.677 171.429 1.00 42.45  ? 153  TYR A OH  1 
ATOM   1053 N  N   . VAL A 1 189 ? 160.191 158.286 168.430 1.00 41.18  ? 154  VAL A N   1 
ATOM   1054 C  CA  . VAL A 1 189 ? 159.356 159.479 168.560 1.00 41.18  ? 154  VAL A CA  1 
ATOM   1055 C  C   . VAL A 1 189 ? 158.362 159.386 169.710 1.00 41.18  ? 154  VAL A C   1 
ATOM   1056 O  O   . VAL A 1 189 ? 157.808 160.418 170.116 1.00 41.18  ? 154  VAL A O   1 
ATOM   1057 C  CB  . VAL A 1 189 ? 158.554 159.793 167.284 1.00 41.18  ? 154  VAL A CB  1 
ATOM   1058 C  CG1 . VAL A 1 189 ? 159.453 160.378 166.202 1.00 41.18  ? 154  VAL A CG1 1 
ATOM   1059 C  CG2 . VAL A 1 189 ? 157.773 158.584 166.817 1.00 41.18  ? 154  VAL A CG2 1 
ATOM   1060 N  N   . VAL A 1 190 ? 158.099 158.188 170.223 1.00 50.44  ? 155  VAL A N   1 
ATOM   1061 C  CA  . VAL A 1 190 ? 157.211 158.044 171.381 1.00 50.44  ? 155  VAL A CA  1 
ATOM   1062 C  C   . VAL A 1 190 ? 157.843 158.742 172.579 1.00 50.44  ? 155  VAL A C   1 
ATOM   1063 O  O   . VAL A 1 190 ? 159.022 158.482 172.893 1.00 50.44  ? 155  VAL A O   1 
ATOM   1064 C  CB  . VAL A 1 190 ? 156.955 156.558 171.680 1.00 50.44  ? 155  VAL A CB  1 
ATOM   1065 C  CG1 . VAL A 1 190 ? 155.982 156.403 172.832 1.00 50.44  ? 155  VAL A CG1 1 
ATOM   1066 C  CG2 . VAL A 1 190 ? 156.426 155.857 170.443 1.00 50.44  ? 155  VAL A CG2 1 
ATOM   1067 N  N   . PRO A 1 191 ? 157.132 159.639 173.263 1.00 62.91  ? 156  PRO A N   1 
ATOM   1068 C  CA  . PRO A 1 191 ? 157.753 160.404 174.350 1.00 62.91  ? 156  PRO A CA  1 
ATOM   1069 C  C   . PRO A 1 191 ? 158.158 159.525 175.521 1.00 62.91  ? 156  PRO A C   1 
ATOM   1070 O  O   . PRO A 1 191 ? 157.566 158.473 175.776 1.00 62.91  ? 156  PRO A O   1 
ATOM   1071 C  CB  . PRO A 1 191 ? 156.656 161.396 174.754 1.00 62.91  ? 156  PRO A CB  1 
ATOM   1072 C  CG  . PRO A 1 191 ? 155.386 160.738 174.332 1.00 62.91  ? 156  PRO A CG  1 
ATOM   1073 C  CD  . PRO A 1 191 ? 155.722 160.015 173.062 1.00 62.91  ? 156  PRO A CD  1 
ATOM   1074 N  N   . ASP A 1 192 ? 159.200 159.969 176.224 1.00 73.99  ? 157  ASP A N   1 
ATOM   1075 C  CA  . ASP A 1 192 ? 159.720 159.225 177.364 1.00 73.99  ? 157  ASP A CA  1 
ATOM   1076 C  C   . ASP A 1 192 ? 158.679 159.164 178.474 1.00 73.99  ? 157  ASP A C   1 
ATOM   1077 O  O   . ASP A 1 192 ? 157.944 160.125 178.715 1.00 73.99  ? 157  ASP A O   1 
ATOM   1078 C  CB  . ASP A 1 192 ? 161.007 159.874 177.876 1.00 73.99  ? 157  ASP A CB  1 
ATOM   1079 C  CG  . ASP A 1 192 ? 161.877 158.911 178.668 1.00 73.99  ? 157  ASP A CG  1 
ATOM   1080 O  OD1 . ASP A 1 192 ? 161.340 157.937 179.237 1.00 73.99  ? 157  ASP A OD1 1 
ATOM   1081 O  OD2 . ASP A 1 192 ? 163.105 159.132 178.721 1.00 73.99  ? 157  ASP A OD2 1 
ATOM   1082 N  N   . GLY A 1 193 ? 158.620 158.020 179.150 1.00 72.90  ? 158  GLY A N   1 
ATOM   1083 C  CA  . GLY A 1 193 ? 157.580 157.768 180.121 1.00 72.90  ? 158  GLY A CA  1 
ATOM   1084 C  C   . GLY A 1 193 ? 156.286 157.250 179.537 1.00 72.90  ? 158  GLY A C   1 
ATOM   1085 O  O   . GLY A 1 193 ? 155.332 157.023 180.293 1.00 72.90  ? 158  GLY A O   1 
ATOM   1086 N  N   . GLU A 1 194 ? 156.220 157.060 178.222 1.00 70.17  ? 159  GLU A N   1 
ATOM   1087 C  CA  . GLU A 1 194 ? 155.038 156.539 177.556 1.00 70.17  ? 159  GLU A CA  1 
ATOM   1088 C  C   . GLU A 1 194 ? 155.441 155.388 176.648 1.00 70.17  ? 159  GLU A C   1 
ATOM   1089 O  O   . GLU A 1 194 ? 156.535 155.381 176.077 1.00 70.17  ? 159  GLU A O   1 
ATOM   1090 C  CB  . GLU A 1 194 ? 154.324 157.625 176.739 1.00 70.17  ? 159  GLU A CB  1 
ATOM   1091 C  CG  . GLU A 1 194 ? 153.604 158.665 177.580 1.00 70.17  ? 159  GLU A CG  1 
ATOM   1092 C  CD  . GLU A 1 194 ? 152.901 159.711 176.737 1.00 70.17  ? 159  GLU A CD  1 
ATOM   1093 O  OE1 . GLU A 1 194 ? 152.543 159.402 175.582 1.00 70.17  ? 159  GLU A OE1 1 
ATOM   1094 O  OE2 . GLU A 1 194 ? 152.709 160.843 177.229 1.00 70.17  ? 159  GLU A OE2 1 
ATOM   1095 N  N   . THR A 1 195 ? 154.550 154.411 176.526 1.00 60.90  ? 160  THR A N   1 
ATOM   1096 C  CA  . THR A 1 195 ? 154.781 153.250 175.683 1.00 60.90  ? 160  THR A CA  1 
ATOM   1097 C  C   . THR A 1 195 ? 153.532 152.965 174.862 1.00 60.90  ? 160  THR A C   1 
ATOM   1098 O  O   . THR A 1 195 ? 152.422 153.374 175.213 1.00 60.90  ? 160  THR A O   1 
ATOM   1099 C  CB  . THR A 1 195 ? 155.177 152.014 176.510 1.00 60.90  ? 160  THR A CB  1 
ATOM   1100 O  OG1 . THR A 1 195 ? 155.729 151.014 175.645 1.00 60.90  ? 160  THR A OG1 1 
ATOM   1101 C  CG2 . THR A 1 195 ? 153.976 151.439 177.250 1.00 60.90  ? 160  THR A CG2 1 
ATOM   1102 N  N   . ARG A 1 196 ? 153.732 152.275 173.743 1.00 54.10  ? 161  ARG A N   1 
ATOM   1103 C  CA  . ARG A 1 196 ? 152.649 151.909 172.845 1.00 54.10  ? 161  ARG A CA  1 
ATOM   1104 C  C   . ARG A 1 196 ? 152.679 150.408 172.617 1.00 54.10  ? 161  ARG A C   1 
ATOM   1105 O  O   . ARG A 1 196 ? 153.752 149.804 172.536 1.00 54.10  ? 161  ARG A O   1 
ATOM   1106 C  CB  . ARG A 1 196 ? 152.755 152.637 171.501 1.00 54.10  ? 161  ARG A CB  1 
ATOM   1107 C  CG  . ARG A 1 196 ? 153.088 154.114 171.604 1.00 54.10  ? 161  ARG A CG  1 
ATOM   1108 C  CD  . ARG A 1 196 ? 151.892 154.928 172.054 1.00 54.10  ? 161  ARG A CD  1 
ATOM   1109 N  NE  . ARG A 1 196 ? 152.271 156.296 172.386 1.00 54.10  ? 161  ARG A NE  1 
ATOM   1110 C  CZ  . ARG A 1 196 ? 151.411 157.262 172.675 1.00 54.10  ? 161  ARG A CZ  1 
ATOM   1111 N  NH1 . ARG A 1 196 ? 150.109 157.039 172.713 1.00 54.10  ? 161  ARG A NH1 1 
ATOM   1112 N  NH2 . ARG A 1 196 ? 151.871 158.482 172.939 1.00 54.10  ? 161  ARG A NH2 1 
ATOM   1113 N  N   . LYS A 1 197 ? 151.497 149.812 172.514 1.00 64.14  ? 162  LYS A N   1 
ATOM   1114 C  CA  . LYS A 1 197 ? 151.357 148.380 172.311 1.00 64.14  ? 162  LYS A CA  1 
ATOM   1115 C  C   . LYS A 1 197 ? 150.360 148.127 171.192 1.00 64.14  ? 162  LYS A C   1 
ATOM   1116 O  O   . LYS A 1 197 ? 149.380 148.860 171.038 1.00 64.14  ? 162  LYS A O   1 
ATOM   1117 C  CB  . LYS A 1 197 ? 150.889 147.685 173.596 1.00 64.14  ? 162  LYS A CB  1 
ATOM   1118 C  CG  . LYS A 1 197 ? 151.137 146.188 173.641 1.00 64.14  ? 162  LYS A CG  1 
ATOM   1119 C  CD  . LYS A 1 197 ? 150.795 145.633 175.014 1.00 64.14  ? 162  LYS A CD  1 
ATOM   1120 C  CE  . LYS A 1 197 ? 151.103 144.151 175.109 1.00 64.14  ? 162  LYS A CE  1 
ATOM   1121 N  NZ  . LYS A 1 197 ? 150.834 143.612 176.470 1.00 64.14  ? 162  LYS A NZ  1 
ATOM   1122 N  N   . ILE A 1 198 ? 150.662 147.136 170.351 1.00 71.89  ? 163  ILE A N   1 
ATOM   1123 C  CA  . ILE A 1 198 ? 149.732 146.781 169.239 1.00 71.89  ? 163  ILE A CA  1 
ATOM   1124 C  C   . ILE A 1 198 ? 148.518 146.088 169.855 1.00 71.89  ? 163  ILE A C   1 
ATOM   1125 O  O   . ILE A 1 198 ? 148.682 144.976 170.389 1.00 71.89  ? 163  ILE A O   1 
ATOM   1126 C  CB  . ILE A 1 198 ? 150.426 145.902 168.180 1.00 71.89  ? 163  ILE A CB  1 
ATOM   1127 C  CG1 . ILE A 1 198 ? 151.664 146.583 167.596 1.00 71.89  ? 163  ILE A CG1 1 
ATOM   1128 C  CG2 . ILE A 1 198 ? 149.449 145.512 167.084 1.00 71.89  ? 163  ILE A CG2 1 
ATOM   1129 C  CD1 . ILE A 1 198 ? 152.258 145.844 166.423 1.00 71.89  ? 163  ILE A CD1 1 
ATOM   1130 N  N   . LYS A 1 199 ? 147.351 146.731 169.794 1.00 85.12  ? 164  LYS A N   1 
ATOM   1131 C  CA  . LYS A 1 199 ? 146.132 146.158 170.417 1.00 85.12  ? 164  LYS A CA  1 
ATOM   1132 C  C   . LYS A 1 199 ? 145.801 144.830 169.730 1.00 85.12  ? 164  LYS A C   1 
ATOM   1133 O  O   . LYS A 1 199 ? 145.450 143.871 170.442 1.00 85.12  ? 164  LYS A O   1 
ATOM   1134 C  CB  . LYS A 1 199 ? 144.978 147.156 170.300 1.00 85.12  ? 164  LYS A CB  1 
ATOM   1135 C  CG  . LYS A 1 199 ? 143.625 146.675 170.805 1.00 85.12  ? 164  LYS A CG  1 
ATOM   1136 C  CD  . LYS A 1 199 ? 143.588 146.411 172.293 1.00 85.12  ? 164  LYS A CD  1 
ATOM   1137 C  CE  . LYS A 1 199 ? 142.219 145.984 172.775 1.00 85.12  ? 164  LYS A CE  1 
ATOM   1138 N  NZ  . LYS A 1 199 ? 142.241 145.588 174.203 1.00 85.12  ? 164  LYS A NZ  1 
ATOM   1139 N  N   . HIS A 1 200 ? 145.927 144.777 168.401 1.00 87.98  ? 165  HIS A N   1 
ATOM   1140 C  CA  . HIS A 1 200 ? 145.614 143.529 167.657 1.00 87.98  ? 165  HIS A CA  1 
ATOM   1141 C  C   . HIS A 1 200 ? 146.907 142.890 167.138 1.00 87.98  ? 165  HIS A C   1 
ATOM   1142 O  O   . HIS A 1 200 ? 147.325 143.244 166.023 1.00 87.98  ? 165  HIS A O   1 
ATOM   1143 C  CB  . HIS A 1 200 ? 144.640 143.859 166.521 1.00 87.98  ? 165  HIS A CB  1 
ATOM   1144 C  CG  . HIS A 1 200 ? 143.521 144.744 166.949 1.00 87.98  ? 165  HIS A CG  1 
ATOM   1145 N  ND1 . HIS A 1 200 ? 142.467 144.283 167.710 1.00 87.98  ? 165  HIS A ND1 1 
ATOM   1146 C  CD2 . HIS A 1 200 ? 143.291 146.057 166.736 1.00 87.98  ? 165  HIS A CD2 1 
ATOM   1147 C  CE1 . HIS A 1 200 ? 141.633 145.274 167.947 1.00 87.98  ? 165  HIS A CE1 1 
ATOM   1148 N  NE2 . HIS A 1 200 ? 142.115 146.371 167.359 1.00 87.98  ? 165  HIS A NE2 1 
ATOM   1149 N  N   . LEU A 1 201 ? 147.489 141.956 167.898 1.00 80.98  ? 166  LEU A N   1 
ATOM   1150 C  CA  . LEU A 1 201 ? 148.728 141.254 167.464 1.00 80.98  ? 166  LEU A CA  1 
ATOM   1151 C  C   . LEU A 1 201 ? 148.434 140.377 166.247 1.00 80.98  ? 166  LEU A C   1 
ATOM   1152 O  O   . LEU A 1 201 ? 149.279 140.335 165.343 1.00 80.98  ? 166  LEU A O   1 
ATOM   1153 C  CB  . LEU A 1 201 ? 149.267 140.417 168.626 1.00 80.98  ? 166  LEU A CB  1 
ATOM   1154 C  CG  . LEU A 1 201 ? 150.510 139.580 168.326 1.00 80.98  ? 166  LEU A CG  1 
ATOM   1155 C  CD1 . LEU A 1 201 ? 151.646 140.452 167.817 1.00 80.98  ? 166  LEU A CD1 1 
ATOM   1156 C  CD2 . LEU A 1 201 ? 150.948 138.803 169.557 1.00 80.98  ? 166  LEU A CD2 1 
ATOM   1157 N  N   . ARG A 1 202 ? 147.290 139.690 166.234 1.00 88.55  ? 167  ARG A N   1 
ATOM   1158 C  CA  . ARG A 1 202 ? 146.981 138.749 165.123 1.00 88.55  ? 167  ARG A CA  1 
ATOM   1159 C  C   . ARG A 1 202 ? 146.854 139.512 163.801 1.00 88.55  ? 167  ARG A C   1 
ATOM   1160 O  O   . ARG A 1 202 ? 147.273 138.960 162.772 1.00 88.55  ? 167  ARG A O   1 
ATOM   1161 C  CB  . ARG A 1 202 ? 145.773 137.870 165.452 1.00 88.55  ? 167  ARG A CB  1 
ATOM   1162 C  CG  . ARG A 1 202 ? 145.969 136.996 166.683 1.00 88.55  ? 167  ARG A CG  1 
ATOM   1163 C  CD  . ARG A 1 202 ? 144.828 136.019 166.893 1.00 88.55  ? 167  ARG A CD  1 
ATOM   1164 N  NE  . ARG A 1 202 ? 144.956 135.268 168.132 1.00 88.55  ? 167  ARG A NE  1 
ATOM   1165 C  CZ  . ARG A 1 202 ? 145.525 134.072 168.233 1.00 88.55  ? 167  ARG A CZ  1 
ATOM   1166 N  NH1 . ARG A 1 202 ? 146.019 133.480 167.159 1.00 88.55  ? 167  ARG A NH1 1 
ATOM   1167 N  NH2 . ARG A 1 202 ? 145.594 133.470 169.406 1.00 88.55  ? 167  ARG A NH2 1 
ATOM   1168 N  N   . VAL A 1 203 ? 146.288 140.721 163.821 1.00 74.12  ? 168  VAL A N   1 
ATOM   1169 C  CA  . VAL A 1 203 ? 146.236 141.534 162.570 1.00 74.12  ? 168  VAL A CA  1 
ATOM   1170 C  C   . VAL A 1 203 ? 147.673 141.803 162.121 1.00 74.12  ? 168  VAL A C   1 
ATOM   1171 O  O   . VAL A 1 203 ? 147.957 141.595 160.936 1.00 74.12  ? 168  VAL A O   1 
ATOM   1172 C  CB  . VAL A 1 203 ? 145.461 142.848 162.777 1.00 74.12  ? 168  VAL A CB  1 
ATOM   1173 C  CG1 . VAL A 1 203 ? 145.903 143.939 161.815 1.00 74.12  ? 168  VAL A CG1 1 
ATOM   1174 C  CG2 . VAL A 1 203 ? 143.959 142.638 162.691 1.00 74.12  ? 168  VAL A CG2 1 
ATOM   1175 N  N   . PHE A 1 204 ? 148.561 142.157 163.054 1.00 64.58  ? 169  PHE A N   1 
ATOM   1176 C  CA  . PHE A 1 204 ? 149.975 142.454 162.703 1.00 64.58  ? 169  PHE A CA  1 
ATOM   1177 C  C   . PHE A 1 204 ? 150.629 141.200 162.117 1.00 64.58  ? 169  PHE A C   1 
ATOM   1178 O  O   . PHE A 1 204 ? 151.357 141.328 161.132 1.00 64.58  ? 169  PHE A O   1 
ATOM   1179 C  CB  . PHE A 1 204 ? 150.745 142.995 163.910 1.00 64.58  ? 169  PHE A CB  1 
ATOM   1180 C  CG  . PHE A 1 204 ? 152.241 142.821 163.852 1.00 64.58  ? 169  PHE A CG  1 
ATOM   1181 C  CD1 . PHE A 1 204 ? 153.023 143.645 163.061 1.00 64.58  ? 169  PHE A CD1 1 
ATOM   1182 C  CD2 . PHE A 1 204 ? 152.871 141.841 164.601 1.00 64.58  ? 169  PHE A CD2 1 
ATOM   1183 C  CE1 . PHE A 1 204 ? 154.398 143.485 163.012 1.00 64.58  ? 169  PHE A CE1 1 
ATOM   1184 C  CE2 . PHE A 1 204 ? 154.246 141.681 164.552 1.00 64.58  ? 169  PHE A CE2 1 
ATOM   1185 C  CZ  . PHE A 1 204 ? 155.007 142.504 163.758 1.00 64.58  ? 169  PHE A CZ  1 
ATOM   1186 N  N   . PHE A 1 205 ? 150.357 140.029 162.694 1.00 71.88  ? 170  PHE A N   1 
ATOM   1187 C  CA  . PHE A 1 205 ? 150.917 138.763 162.159 1.00 71.88  ? 170  PHE A CA  1 
ATOM   1188 C  C   . PHE A 1 205 ? 150.462 138.581 160.713 1.00 71.88  ? 170  PHE A C   1 
ATOM   1189 O  O   . PHE A 1 205 ? 151.327 138.518 159.832 1.00 71.88  ? 170  PHE A O   1 
ATOM   1190 C  CB  . PHE A 1 205 ? 150.453 137.562 162.983 1.00 71.88  ? 170  PHE A CB  1 
ATOM   1191 C  CG  . PHE A 1 205 ? 151.265 137.289 164.221 1.00 71.88  ? 170  PHE A CG  1 
ATOM   1192 C  CD1 . PHE A 1 205 ? 152.630 137.523 164.237 1.00 71.88  ? 170  PHE A CD1 1 
ATOM   1193 C  CD2 . PHE A 1 205 ? 150.669 136.777 165.360 1.00 71.88  ? 170  PHE A CD2 1 
ATOM   1194 C  CE1 . PHE A 1 205 ? 153.377 137.263 165.373 1.00 71.88  ? 170  PHE A CE1 1 
ATOM   1195 C  CE2 . PHE A 1 205 ? 151.418 136.514 166.495 1.00 71.88  ? 170  PHE A CE2 1 
ATOM   1196 C  CZ  . PHE A 1 205 ? 152.771 136.759 166.499 1.00 71.88  ? 170  PHE A CZ  1 
ATOM   1197 N  N   . VAL A 1 206 ? 149.149 138.484 160.486 1.00 63.61  ? 171  VAL A N   1 
ATOM   1198 C  CA  . VAL A 1 206 ? 148.656 138.244 159.129 1.00 63.61  ? 171  VAL A CA  1 
ATOM   1199 C  C   . VAL A 1 206 ? 149.250 139.255 158.156 1.00 63.61  ? 171  VAL A C   1 
ATOM   1200 O  O   . VAL A 1 206 ? 149.734 138.894 157.076 1.00 63.61  ? 171  VAL A O   1 
ATOM   1201 C  CB  . VAL A 1 206 ? 147.118 138.276 159.102 1.00 63.61  ? 171  VAL A CB  1 
ATOM   1202 C  CG1 . VAL A 1 206 ? 146.610 138.199 157.672 1.00 63.61  ? 171  VAL A CG1 1 
ATOM   1203 C  CG2 . VAL A 1 206 ? 146.552 137.131 159.918 1.00 63.61  ? 171  VAL A CG2 1 
ATOM   1204 N  N   . THR A 1 207 ? 149.238 140.536 158.532 1.00 52.62  ? 172  THR A N   1 
ATOM   1205 C  CA  . THR A 1 207 ? 149.750 141.572 157.640 1.00 52.62  ? 172  THR A CA  1 
ATOM   1206 C  C   . THR A 1 207 ? 151.255 141.447 157.430 1.00 52.62  ? 172  THR A C   1 
ATOM   1207 O  O   . THR A 1 207 ? 151.732 141.598 156.302 1.00 52.62  ? 172  THR A O   1 
ATOM   1208 C  CB  . THR A 1 207 ? 149.394 142.962 158.167 1.00 52.62  ? 172  THR A CB  1 
ATOM   1209 O  OG1 . THR A 1 207 ? 149.949 143.144 159.475 1.00 52.62  ? 172  THR A OG1 1 
ATOM   1210 C  CG2 . THR A 1 207 ? 147.887 143.168 158.192 1.00 52.62  ? 172  THR A CG2 1 
ATOM   1211 N  N   . ALA A 1 208 ? 152.022 141.179 158.492 1.00 46.74  ? 173  ALA A N   1 
ATOM   1212 C  CA  . ALA A 1 208 ? 153.467 141.036 158.329 1.00 46.74  ? 173  ALA A CA  1 
ATOM   1213 C  C   . ALA A 1 208 ? 153.811 139.821 157.476 1.00 46.74  ? 173  ALA A C   1 
ATOM   1214 O  O   . ALA A 1 208 ? 154.714 139.881 156.627 1.00 46.74  ? 173  ALA A O   1 
ATOM   1215 C  CB  . ALA A 1 208 ? 154.146 140.944 159.694 1.00 46.74  ? 173  ALA A CB  1 
ATOM   1216 N  N   . ALA A 1 209 ? 153.095 138.709 157.681 1.00 46.02  ? 174  ALA A N   1 
ATOM   1217 C  CA  . ALA A 1 209 ? 153.312 137.528 156.855 1.00 46.02  ? 174  ALA A CA  1 
ATOM   1218 C  C   . ALA A 1 209 ? 152.980 137.809 155.398 1.00 46.02  ? 174  ALA A C   1 
ATOM   1219 O  O   . ALA A 1 209 ? 153.716 137.393 154.501 1.00 46.02  ? 174  ALA A O   1 
ATOM   1220 C  CB  . ALA A 1 209 ? 152.482 136.358 157.381 1.00 46.02  ? 174  ALA A CB  1 
ATOM   1221 N  N   . TRP A 1 210 ? 151.887 138.535 155.145 1.00 43.85  ? 175  TRP A N   1 
ATOM   1222 C  CA  . TRP A 1 210 ? 151.516 138.888 153.777 1.00 43.85  ? 175  TRP A CA  1 
ATOM   1223 C  C   . TRP A 1 210 ? 152.553 139.808 153.140 1.00 43.85  ? 175  TRP A C   1 
ATOM   1224 O  O   . TRP A 1 210 ? 152.898 139.650 151.960 1.00 43.85  ? 175  TRP A O   1 
ATOM   1225 C  CB  . TRP A 1 210 ? 150.133 139.540 153.786 1.00 43.85  ? 175  TRP A CB  1 
ATOM   1226 C  CG  . TRP A 1 210 ? 149.429 139.570 152.467 1.00 43.85  ? 175  TRP A CG  1 
ATOM   1227 C  CD1 . TRP A 1 210 ? 149.068 140.677 151.759 1.00 43.85  ? 175  TRP A CD1 1 
ATOM   1228 C  CD2 . TRP A 1 210 ? 148.978 138.443 151.705 1.00 43.85  ? 175  TRP A CD2 1 
ATOM   1229 N  NE1 . TRP A 1 210 ? 148.426 140.311 150.602 1.00 43.85  ? 175  TRP A NE1 1 
ATOM   1230 C  CE2 . TRP A 1 210 ? 148.361 138.945 150.543 1.00 43.85  ? 175  TRP A CE2 1 
ATOM   1231 C  CE3 . TRP A 1 210 ? 149.042 137.059 151.889 1.00 43.85  ? 175  TRP A CE3 1 
ATOM   1232 C  CZ2 . TRP A 1 210 ? 147.812 138.113 149.571 1.00 43.85  ? 175  TRP A CZ2 1 
ATOM   1233 C  CZ3 . TRP A 1 210 ? 148.496 136.235 150.922 1.00 43.85  ? 175  TRP A CZ3 1 
ATOM   1234 C  CH2 . TRP A 1 210 ? 147.890 136.765 149.778 1.00 43.85  ? 175  TRP A CH2 1 
ATOM   1235 N  N   . SER A 1 211 ? 153.074 140.761 153.918 1.00 34.08  ? 176  SER A N   1 
ATOM   1236 C  CA  . SER A 1 211 ? 154.072 141.696 153.411 1.00 34.08  ? 176  SER A CA  1 
ATOM   1237 C  C   . SER A 1 211 ? 155.353 140.978 153.007 1.00 34.08  ? 176  SER A C   1 
ATOM   1238 O  O   . SER A 1 211 ? 155.883 141.205 151.915 1.00 34.08  ? 176  SER A O   1 
ATOM   1239 C  CB  . SER A 1 211 ? 154.365 142.762 154.466 1.00 34.08  ? 176  SER A CB  1 
ATOM   1240 O  OG  . SER A 1 211 ? 155.300 143.709 153.986 1.00 34.08  ? 176  SER A OG  1 
ATOM   1241 N  N   . ILE A 1 212 ? 155.862 140.098 153.872 1.00 33.16  ? 177  ILE A N   1 
ATOM   1242 C  CA  . ILE A 1 212 ? 157.068 139.344 153.526 1.00 33.16  ? 177  ILE A CA  1 
ATOM   1243 C  C   . ILE A 1 212 ? 156.776 138.345 152.405 1.00 33.16  ? 177  ILE A C   1 
ATOM   1244 O  O   . ILE A 1 212 ? 157.639 138.075 151.548 1.00 33.16  ? 177  ILE A O   1 
ATOM   1245 C  CB  . ILE A 1 212 ? 157.629 138.665 154.789 1.00 33.16  ? 177  ILE A CB  1 
ATOM   1246 C  CG1 . ILE A 1 212 ? 158.116 139.723 155.778 1.00 33.16  ? 177  ILE A CG1 1 
ATOM   1247 C  CG2 . ILE A 1 212 ? 158.775 137.732 154.453 1.00 33.16  ? 177  ILE A CG2 1 
ATOM   1248 C  CD1 . ILE A 1 212 ? 158.601 139.155 157.089 1.00 33.16  ? 177  ILE A CD1 1 
ATOM   1249 N  N   . PHE A 1 213 ? 155.555 137.805 152.376 1.00 37.40  ? 178  PHE A N   1 
ATOM   1250 C  CA  . PHE A 1 213 ? 155.179 136.828 151.367 1.00 37.40  ? 178  PHE A CA  1 
ATOM   1251 C  C   . PHE A 1 213 ? 155.136 137.445 149.978 1.00 37.40  ? 178  PHE A C   1 
ATOM   1252 O  O   . PHE A 1 213 ? 155.425 136.759 148.994 1.00 37.40  ? 178  PHE A O   1 
ATOM   1253 C  CB  . PHE A 1 213 ? 153.832 136.206 151.735 1.00 37.40  ? 178  PHE A CB  1 
ATOM   1254 C  CG  . PHE A 1 213 ? 153.186 135.449 150.619 1.00 37.40  ? 178  PHE A CG  1 
ATOM   1255 C  CD1 . PHE A 1 213 ? 153.794 134.326 150.082 1.00 37.40  ? 178  PHE A CD1 1 
ATOM   1256 C  CD2 . PHE A 1 213 ? 151.965 135.851 150.116 1.00 37.40  ? 178  PHE A CD2 1 
ATOM   1257 C  CE1 . PHE A 1 213 ? 153.198 133.627 149.054 1.00 37.40  ? 178  PHE A CE1 1 
ATOM   1258 C  CE2 . PHE A 1 213 ? 151.364 135.155 149.096 1.00 37.40  ? 178  PHE A CE2 1 
ATOM   1259 C  CZ  . PHE A 1 213 ? 151.981 134.042 148.560 1.00 37.40  ? 178  PHE A CZ  1 
ATOM   1260 N  N   . ALA A 1 214 ? 154.800 138.734 149.883 1.00 29.82  ? 179  ALA A N   1 
ATOM   1261 C  CA  . ALA A 1 214 ? 154.855 139.426 148.595 1.00 29.82  ? 179  ALA A CA  1 
ATOM   1262 C  C   . ALA A 1 214 ? 156.251 139.351 147.983 1.00 29.82  ? 179  ALA A C   1 
ATOM   1263 O  O   . ALA A 1 214 ? 156.418 139.006 146.805 1.00 29.82  ? 179  ALA A O   1 
ATOM   1264 C  CB  . ALA A 1 214 ? 154.431 140.882 148.770 1.00 29.82  ? 179  ALA A CB  1 
ATOM   1265 N  N   . TYR A 1 215 ? 157.273 139.636 148.785 1.00 24.97  ? 180  TYR A N   1 
ATOM   1266 C  CA  . TYR A 1 215 ? 158.631 139.691 148.259 1.00 24.97  ? 180  TYR A CA  1 
ATOM   1267 C  C   . TYR A 1 215 ? 159.193 138.295 148.015 1.00 24.97  ? 180  TYR A C   1 
ATOM   1268 O  O   . TYR A 1 215 ? 159.906 138.071 147.024 1.00 24.97  ? 180  TYR A O   1 
ATOM   1269 C  CB  . TYR A 1 215 ? 159.507 140.513 149.205 1.00 24.97  ? 180  TYR A CB  1 
ATOM   1270 C  CG  . TYR A 1 215 ? 159.066 141.957 149.241 1.00 24.97  ? 180  TYR A CG  1 
ATOM   1271 C  CD1 . TYR A 1 215 ? 158.034 142.365 150.070 1.00 24.97  ? 180  TYR A CD1 1 
ATOM   1272 C  CD2 . TYR A 1 215 ? 159.661 142.906 148.429 1.00 24.97  ? 180  TYR A CD2 1 
ATOM   1273 C  CE1 . TYR A 1 215 ? 157.606 143.665 150.093 1.00 24.97  ? 180  TYR A CE1 1 
ATOM   1274 C  CE2 . TYR A 1 215 ? 159.247 144.219 148.456 1.00 24.97  ? 180  TYR A CE2 1 
ATOM   1275 C  CZ  . TYR A 1 215 ? 158.210 144.588 149.286 1.00 24.97  ? 180  TYR A CZ  1 
ATOM   1276 O  OH  . TYR A 1 215 ? 157.772 145.889 149.324 1.00 24.97  ? 180  TYR A OH  1 
ATOM   1277 N  N   . THR A 1 216 ? 158.860 137.326 148.874 1.00 30.86  ? 181  THR A N   1 
ATOM   1278 C  CA  . THR A 1 216 ? 159.327 135.979 148.552 1.00 30.86  ? 181  THR A CA  1 
ATOM   1279 C  C   . THR A 1 216 ? 158.593 135.421 147.335 1.00 30.86  ? 181  THR A C   1 
ATOM   1280 O  O   . THR A 1 216 ? 159.160 134.612 146.599 1.00 30.86  ? 181  THR A O   1 
ATOM   1281 C  CB  . THR A 1 216 ? 159.209 135.024 149.742 1.00 30.86  ? 181  THR A CB  1 
ATOM   1282 O  OG1 . THR A 1 216 ? 159.735 133.746 149.366 1.00 30.86  ? 181  THR A OG1 1 
ATOM   1283 C  CG2 . THR A 1 216 ? 157.782 134.814 150.137 1.00 30.86  ? 181  THR A CG2 1 
ATOM   1284 N  N   . TRP A 1 217 ? 157.364 135.879 147.067 1.00 32.34  ? 182  TRP A N   1 
ATOM   1285 C  CA  . TRP A 1 217 ? 156.682 135.500 145.832 1.00 32.34  ? 182  TRP A CA  1 
ATOM   1286 C  C   . TRP A 1 217 ? 157.339 136.141 144.619 1.00 32.34  ? 182  TRP A C   1 
ATOM   1287 O  O   . TRP A 1 217 ? 157.386 135.537 143.540 1.00 32.34  ? 182  TRP A O   1 
ATOM   1288 C  CB  . TRP A 1 217 ? 155.207 135.887 145.911 1.00 32.34  ? 182  TRP A CB  1 
ATOM   1289 C  CG  . TRP A 1 217 ? 154.478 135.757 144.615 1.00 32.34  ? 182  TRP A CG  1 
ATOM   1290 C  CD1 . TRP A 1 217 ? 154.050 136.773 143.817 1.00 32.34  ? 182  TRP A CD1 1 
ATOM   1291 C  CD2 . TRP A 1 217 ? 154.091 134.542 143.963 1.00 32.34  ? 182  TRP A CD2 1 
ATOM   1292 N  NE1 . TRP A 1 217 ? 153.416 136.270 142.708 1.00 32.34  ? 182  TRP A NE1 1 
ATOM   1293 C  CE2 . TRP A 1 217 ? 153.426 134.902 142.775 1.00 32.34  ? 182  TRP A CE2 1 
ATOM   1294 C  CE3 . TRP A 1 217 ? 154.239 133.186 144.269 1.00 32.34  ? 182  TRP A CE3 1 
ATOM   1295 C  CZ2 . TRP A 1 217 ? 152.915 133.955 141.890 1.00 32.34  ? 182  TRP A CZ2 1 
ATOM   1296 C  CZ3 . TRP A 1 217 ? 153.729 132.248 143.389 1.00 32.34  ? 182  TRP A CZ3 1 
ATOM   1297 C  CH2 . TRP A 1 217 ? 153.076 132.637 142.214 1.00 32.34  ? 182  TRP A CH2 1 
ATOM   1298 N  N   . LEU A 1 218 ? 157.830 137.373 144.772 1.00 30.44  ? 183  LEU A N   1 
ATOM   1299 C  CA  . LEU A 1 218 ? 158.638 137.987 143.719 1.00 30.44  ? 183  LEU A CA  1 
ATOM   1300 C  C   . LEU A 1 218 ? 159.855 137.126 143.401 1.00 30.44  ? 183  LEU A C   1 
ATOM   1301 O  O   . LEU A 1 218 ? 160.164 136.860 142.229 1.00 30.44  ? 183  LEU A O   1 
ATOM   1302 C  CB  . LEU A 1 218 ? 159.074 139.386 144.151 1.00 30.44  ? 183  LEU A CB  1 
ATOM   1303 C  CG  . LEU A 1 218 ? 159.675 140.292 143.083 1.00 30.44  ? 183  LEU A CG  1 
ATOM   1304 C  CD1 . LEU A 1 218 ? 158.657 140.555 142.000 1.00 30.44  ? 183  LEU A CD1 1 
ATOM   1305 C  CD2 . LEU A 1 218 ? 160.162 141.587 143.704 1.00 30.44  ? 183  LEU A CD2 1 
ATOM   1306 N  N   . TYR A 1 219 ? 160.542 136.658 144.447 1.00 33.15  ? 184  TYR A N   1 
ATOM   1307 C  CA  . TYR A 1 219 ? 161.671 135.750 144.249 1.00 33.15  ? 184  TYR A CA  1 
ATOM   1308 C  C   . TYR A 1 219 ? 161.227 134.442 143.603 1.00 33.15  ? 184  TYR A C   1 
ATOM   1309 O  O   . TYR A 1 219 ? 161.975 133.843 142.822 1.00 33.15  ? 184  TYR A O   1 
ATOM   1310 C  CB  . TYR A 1 219 ? 162.374 135.488 145.585 1.00 33.15  ? 184  TYR A CB  1 
ATOM   1311 C  CG  . TYR A 1 219 ? 163.530 134.504 145.528 1.00 33.15  ? 184  TYR A CG  1 
ATOM   1312 C  CD1 . TYR A 1 219 ? 163.322 133.137 145.681 1.00 33.15  ? 184  TYR A CD1 1 
ATOM   1313 C  CD2 . TYR A 1 219 ? 164.828 134.946 145.322 1.00 33.15  ? 184  TYR A CD2 1 
ATOM   1314 C  CE1 . TYR A 1 219 ? 164.370 132.245 145.628 1.00 33.15  ? 184  TYR A CE1 1 
ATOM   1315 C  CE2 . TYR A 1 219 ? 165.884 134.057 145.271 1.00 33.15  ? 184  TYR A CE2 1 
ATOM   1316 C  CZ  . TYR A 1 219 ? 165.649 132.709 145.424 1.00 33.15  ? 184  TYR A CZ  1 
ATOM   1317 O  OH  . TYR A 1 219 ? 166.697 131.820 145.371 1.00 33.15  ? 184  TYR A OH  1 
ATOM   1318 N  N   . ILE A 1 220 ? 160.024 133.971 143.939 1.00 36.78  ? 185  ILE A N   1 
ATOM   1319 C  CA  . ILE A 1 220 ? 159.509 132.730 143.363 1.00 36.78  ? 185  ILE A CA  1 
ATOM   1320 C  C   . ILE A 1 220 ? 159.319 132.872 141.856 1.00 36.78  ? 185  ILE A C   1 
ATOM   1321 O  O   . ILE A 1 220 ? 159.743 132.011 141.076 1.00 36.78  ? 185  ILE A O   1 
ATOM   1322 C  CB  . ILE A 1 220 ? 158.201 132.316 144.063 1.00 36.78  ? 185  ILE A CB  1 
ATOM   1323 C  CG1 . ILE A 1 220 ? 158.483 131.752 145.457 1.00 36.78  ? 185  ILE A CG1 1 
ATOM   1324 C  CG2 . ILE A 1 220 ? 157.432 131.311 143.232 1.00 36.78  ? 185  ILE A CG2 1 
ATOM   1325 C  CD1 . ILE A 1 220 ? 159.171 130.406 145.453 1.00 36.78  ? 185  ILE A CD1 1 
ATOM   1326 N  N   . ILE A 1 221 ? 158.682 133.963 141.421 1.00 34.89  ? 186  ILE A N   1 
ATOM   1327 C  CA  . ILE A 1 221 ? 158.424 134.103 139.988 1.00 34.89  ? 186  ILE A CA  1 
ATOM   1328 C  C   . ILE A 1 221 ? 159.698 134.438 139.223 1.00 34.89  ? 186  ILE A C   1 
ATOM   1329 O  O   . ILE A 1 221 ? 159.812 134.107 138.037 1.00 34.89  ? 186  ILE A O   1 
ATOM   1330 C  CB  . ILE A 1 221 ? 157.303 135.126 139.695 1.00 34.89  ? 186  ILE A CB  1 
ATOM   1331 C  CG1 . ILE A 1 221 ? 157.844 136.554 139.555 1.00 34.89  ? 186  ILE A CG1 1 
ATOM   1332 C  CG2 . ILE A 1 221 ? 156.173 135.003 140.690 1.00 34.89  ? 186  ILE A CG2 1 
ATOM   1333 C  CD1 . ILE A 1 221 ? 156.782 137.572 139.229 1.00 34.89  ? 186  ILE A CD1 1 
ATOM   1334 N  N   . LEU A 1 222 ? 160.678 135.088 139.860 1.00 36.11  ? 187  LEU A N   1 
ATOM   1335 C  CA  . LEU A 1 222 ? 161.881 135.405 139.096 1.00 36.11  ? 187  LEU A CA  1 
ATOM   1336 C  C   . LEU A 1 222 ? 162.808 134.206 138.933 1.00 36.11  ? 187  LEU A C   1 
ATOM   1337 O  O   . LEU A 1 222 ? 163.407 134.032 137.866 1.00 36.11  ? 187  LEU A O   1 
ATOM   1338 C  CB  . LEU A 1 222 ? 162.634 136.575 139.724 1.00 36.11  ? 187  LEU A CB  1 
ATOM   1339 C  CG  . LEU A 1 222 ? 162.076 137.933 139.298 1.00 36.11  ? 187  LEU A CG  1 
ATOM   1340 C  CD1 . LEU A 1 222 ? 162.948 139.063 139.774 1.00 36.11  ? 187  LEU A CD1 1 
ATOM   1341 C  CD2 . LEU A 1 222 ? 161.925 137.996 137.792 1.00 36.11  ? 187  LEU A CD2 1 
ATOM   1342 N  N   . SER A 1 223 ? 162.958 133.379 139.963 1.00 41.61  ? 188  SER A N   1 
ATOM   1343 C  CA  . SER A 1 223 ? 163.946 132.305 139.913 1.00 41.61  ? 188  SER A CA  1 
ATOM   1344 C  C   . SER A 1 223 ? 163.363 130.906 140.020 1.00 41.61  ? 188  SER A C   1 
ATOM   1345 O  O   . SER A 1 223 ? 163.768 130.024 139.261 1.00 41.61  ? 188  SER A O   1 
ATOM   1346 C  CB  . SER A 1 223 ? 164.991 132.498 141.017 1.00 41.61  ? 188  SER A CB  1 
ATOM   1347 O  OG  . SER A 1 223 ? 165.640 133.744 140.868 1.00 41.61  ? 188  SER A OG  1 
ATOM   1348 N  N   . VAL A 1 224 ? 162.431 130.669 140.943 1.00 40.76  ? 189  VAL A N   1 
ATOM   1349 C  CA  . VAL A 1 224 ? 161.988 129.302 141.212 1.00 40.76  ? 189  VAL A CA  1 
ATOM   1350 C  C   . VAL A 1 224 ? 161.087 128.793 140.091 1.00 40.76  ? 189  VAL A C   1 
ATOM   1351 O  O   . VAL A 1 224 ? 161.402 127.802 139.423 1.00 40.76  ? 189  VAL A O   1 
ATOM   1352 C  CB  . VAL A 1 224 ? 161.289 129.225 142.580 1.00 40.76  ? 189  VAL A CB  1 
ATOM   1353 C  CG1 . VAL A 1 224 ? 160.572 127.894 142.740 1.00 40.76  ? 189  VAL A CG1 1 
ATOM   1354 C  CG2 . VAL A 1 224 ? 162.301 129.430 143.698 1.00 40.76  ? 189  VAL A CG2 1 
ATOM   1355 N  N   . ILE A 1 225 ? 159.959 129.459 139.865 1.00 43.89  ? 190  ILE A N   1 
ATOM   1356 C  CA  . ILE A 1 225 ? 159.008 129.036 138.842 1.00 43.89  ? 190  ILE A CA  1 
ATOM   1357 C  C   . ILE A 1 225 ? 159.274 129.819 137.565 1.00 43.89  ? 190  ILE A C   1 
ATOM   1358 O  O   . ILE A 1 225 ? 159.201 131.053 137.559 1.00 43.89  ? 190  ILE A O   1 
ATOM   1359 C  CB  . ILE A 1 225 ? 157.557 129.226 139.307 1.00 43.89  ? 190  ILE A CB  1 
ATOM   1360 C  CG1 . ILE A 1 225 ? 157.349 128.600 140.684 1.00 43.89  ? 190  ILE A CG1 1 
ATOM   1361 C  CG2 . ILE A 1 225 ? 156.597 128.633 138.293 1.00 43.89  ? 190  ILE A CG2 1 
ATOM   1362 C  CD1 . ILE A 1 225 ? 155.918 128.670 141.172 1.00 43.89  ? 190  ILE A CD1 1 
ATOM   1363 N  N   . SER A 1 226 ? 159.556 129.090 136.476 1.00 47.90  ? 191  SER A N   1 
ATOM   1364 C  CA  . SER A 1 226 ? 159.822 129.626 135.144 1.00 47.90  ? 191  SER A CA  1 
ATOM   1365 C  C   . SER A 1 226 ? 160.916 130.687 135.207 1.00 47.90  ? 191  SER A C   1 
ATOM   1366 O  O   . SER A 1 226 ? 160.627 131.882 135.074 1.00 47.90  ? 191  SER A O   1 
ATOM   1367 C  CB  . SER A 1 226 ? 158.539 130.196 134.537 1.00 47.90  ? 191  SER A CB  1 
ATOM   1368 O  OG  . SER A 1 226 ? 158.736 130.587 133.194 1.00 47.90  ? 191  SER A OG  1 
ATOM   1369 N  N   . PRO A 1 227 ? 162.172 130.291 135.429 1.00 48.27  ? 192  PRO A N   1 
ATOM   1370 C  CA  . PRO A 1 227 ? 163.222 131.278 135.711 1.00 48.27  ? 192  PRO A CA  1 
ATOM   1371 C  C   . PRO A 1 227 ? 163.529 132.169 134.517 1.00 48.27  ? 192  PRO A C   1 
ATOM   1372 O  O   . PRO A 1 227 ? 163.462 131.743 133.362 1.00 48.27  ? 192  PRO A O   1 
ATOM   1373 C  CB  . PRO A 1 227 ? 164.434 130.411 136.074 1.00 48.27  ? 192  PRO A CB  1 
ATOM   1374 C  CG  . PRO A 1 227 ? 164.167 129.100 135.421 1.00 48.27  ? 192  PRO A CG  1 
ATOM   1375 C  CD  . PRO A 1 227 ? 162.684 128.911 135.462 1.00 48.27  ? 192  PRO A CD  1 
ATOM   1376 N  N   . GLY A 1 228 ? 163.868 133.423 134.816 1.00 46.73  ? 193  GLY A N   1 
ATOM   1377 C  CA  . GLY A 1 228 ? 164.343 134.364 133.831 1.00 46.73  ? 193  GLY A CA  1 
ATOM   1378 C  C   . GLY A 1 228 ? 163.268 135.136 133.098 1.00 46.73  ? 193  GLY A C   1 
ATOM   1379 O  O   . GLY A 1 228 ? 163.579 136.151 132.465 1.00 46.73  ? 193  GLY A O   1 
ATOM   1380 N  N   . VAL A 1 229 ? 162.012 134.694 133.162 1.00 48.69  ? 194  VAL A N   1 
ATOM   1381 C  CA  . VAL A 1 229 ? 160.929 135.324 132.423 1.00 48.69  ? 194  VAL A CA  1 
ATOM   1382 C  C   . VAL A 1 229 ? 159.781 135.613 133.379 1.00 48.69  ? 194  VAL A C   1 
ATOM   1383 O  O   . VAL A 1 229 ? 159.710 135.075 134.486 1.00 48.69  ? 194  VAL A O   1 
ATOM   1384 C  CB  . VAL A 1 229 ? 160.426 134.461 131.243 1.00 48.69  ? 194  VAL A CB  1 
ATOM   1385 C  CG1 . VAL A 1 229 ? 161.581 133.982 130.377 1.00 48.69  ? 194  VAL A CG1 1 
ATOM   1386 C  CG2 . VAL A 1 229 ? 159.612 133.295 131.747 1.00 48.69  ? 194  VAL A CG2 1 
ATOM   1387 N  N   . VAL A 1 230 ? 158.883 136.488 132.939 1.00 43.55  ? 195  VAL A N   1 
ATOM   1388 C  CA  . VAL A 1 230 ? 157.649 136.793 133.652 1.00 43.55  ? 195  VAL A CA  1 
ATOM   1389 C  C   . VAL A 1 230 ? 156.508 136.570 132.670 1.00 43.55  ? 195  VAL A C   1 
ATOM   1390 O  O   . VAL A 1 230 ? 156.327 137.353 131.729 1.00 43.55  ? 195  VAL A O   1 
ATOM   1391 C  CB  . VAL A 1 230 ? 157.638 138.224 134.207 1.00 43.55  ? 195  VAL A CB  1 
ATOM   1392 C  CG1 . VAL A 1 230 ? 156.247 138.596 134.699 1.00 43.55  ? 195  VAL A CG1 1 
ATOM   1393 C  CG2 . VAL A 1 230 ? 158.655 138.368 135.321 1.00 43.55  ? 195  VAL A CG2 1 
ATOM   1394 N  N   . GLU A 1 231 ? 155.751 135.497 132.872 1.00 48.28  ? 196  GLU A N   1 
ATOM   1395 C  CA  . GLU A 1 231 ? 154.652 135.180 131.977 1.00 48.28  ? 196  GLU A CA  1 
ATOM   1396 C  C   . GLU A 1 231 ? 153.411 135.973 132.389 1.00 48.28  ? 196  GLU A C   1 
ATOM   1397 O  O   . GLU A 1 231 ? 153.397 136.673 133.405 1.00 48.28  ? 196  GLU A O   1 
ATOM   1398 C  CB  . GLU A 1 231 ? 154.385 133.673 131.988 1.00 48.28  ? 196  GLU A CB  1 
ATOM   1399 C  CG  . GLU A 1 231 ? 154.077 133.044 130.625 1.00 48.28  ? 196  GLU A CG  1 
ATOM   1400 C  CD  . GLU A 1 231 ? 152.631 133.179 130.197 1.00 48.28  ? 196  GLU A CD  1 
ATOM   1401 O  OE1 . GLU A 1 231 ? 151.778 133.476 131.057 1.00 48.28  ? 196  GLU A OE1 1 
ATOM   1402 O  OE2 . GLU A 1 231 ? 152.344 132.985 128.997 1.00 48.28  ? 196  GLU A OE2 1 
ATOM   1403 N  N   . VAL A 1 232 ? 152.363 135.875 131.568 1.00 46.53  ? 197  VAL A N   1 
ATOM   1404 C  CA  . VAL A 1 232 ? 151.110 136.569 131.855 1.00 46.53  ? 197  VAL A CA  1 
ATOM   1405 C  C   . VAL A 1 232 ? 150.480 136.031 133.134 1.00 46.53  ? 197  VAL A C   1 
ATOM   1406 O  O   . VAL A 1 232 ? 150.008 136.799 133.984 1.00 46.53  ? 197  VAL A O   1 
ATOM   1407 C  CB  . VAL A 1 232 ? 150.157 136.447 130.650 1.00 46.53  ? 197  VAL A CB  1 
ATOM   1408 C  CG1 . VAL A 1 232 ? 148.698 136.520 131.083 1.00 46.53  ? 197  VAL A CG1 1 
ATOM   1409 C  CG2 . VAL A 1 232 ? 150.471 137.515 129.622 1.00 46.53  ? 197  VAL A CG2 1 
ATOM   1410 N  N   . TRP A 1 233 ? 150.482 134.706 133.303 1.00 50.33  ? 198  TRP A N   1 
ATOM   1411 C  CA  . TRP A 1 233 ? 149.881 134.087 134.479 1.00 50.33  ? 198  TRP A CA  1 
ATOM   1412 C  C   . TRP A 1 233 ? 150.639 134.389 135.764 1.00 50.33  ? 198  TRP A C   1 
ATOM   1413 O  O   . TRP A 1 233 ? 150.106 134.128 136.846 1.00 50.33  ? 198  TRP A O   1 
ATOM   1414 C  CB  . TRP A 1 233 ? 149.763 132.572 134.275 1.00 50.33  ? 198  TRP A CB  1 
ATOM   1415 C  CG  . TRP A 1 233 ? 151.052 131.805 134.392 1.00 50.33  ? 198  TRP A CG  1 
ATOM   1416 C  CD1 . TRP A 1 233 ? 151.897 131.472 133.375 1.00 50.33  ? 198  TRP A CD1 1 
ATOM   1417 C  CD2 . TRP A 1 233 ? 151.613 131.230 135.580 1.00 50.33  ? 198  TRP A CD2 1 
ATOM   1418 N  NE1 . TRP A 1 233 ? 152.961 130.752 133.857 1.00 50.33  ? 198  TRP A NE1 1 
ATOM   1419 C  CE2 . TRP A 1 233 ? 152.810 130.587 135.208 1.00 50.33  ? 198  TRP A CE2 1 
ATOM   1420 C  CE3 . TRP A 1 233 ? 151.226 131.207 136.923 1.00 50.33  ? 198  TRP A CE3 1 
ATOM   1421 C  CZ2 . TRP A 1 233 ? 153.622 129.930 136.128 1.00 50.33  ? 198  TRP A CZ2 1 
ATOM   1422 C  CZ3 . TRP A 1 233 ? 152.034 130.555 137.835 1.00 50.33  ? 198  TRP A CZ3 1 
ATOM   1423 C  CH2 . TRP A 1 233 ? 153.218 129.926 137.434 1.00 50.33  ? 198  TRP A CH2 1 
ATOM   1424 N  N   . GLU A 1 234 ? 151.856 134.925 135.677 1.00 48.94  ? 199  GLU A N   1 
ATOM   1425 C  CA  . GLU A 1 234 ? 152.583 135.366 136.861 1.00 48.94  ? 199  GLU A CA  1 
ATOM   1426 C  C   . GLU A 1 234 ? 152.260 136.814 137.217 1.00 48.94  ? 199  GLU A C   1 
ATOM   1427 O  O   . GLU A 1 234 ? 151.905 137.110 138.362 1.00 48.94  ? 199  GLU A O   1 
ATOM   1428 C  CB  . GLU A 1 234 ? 154.090 135.197 136.649 1.00 48.94  ? 199  GLU A CB  1 
ATOM   1429 C  CG  . GLU A 1 234 ? 154.568 133.756 136.668 1.00 48.94  ? 199  GLU A CG  1 
ATOM   1430 C  CD  . GLU A 1 234 ? 155.938 133.590 136.040 1.00 48.94  ? 199  GLU A CD  1 
ATOM   1431 O  OE1 . GLU A 1 234 ? 156.914 134.133 136.594 1.00 48.94  ? 199  GLU A OE1 1 
ATOM   1432 O  OE2 . GLU A 1 234 ? 156.041 132.918 134.994 1.00 48.94  ? 199  GLU A OE2 1 
ATOM   1433 N  N   . GLY A 1 235 ? 152.378 137.723 136.246 1.00 43.28  ? 200  GLY A N   1 
ATOM   1434 C  CA  . GLY A 1 235 ? 152.113 139.127 136.519 1.00 43.28  ? 200  GLY A CA  1 
ATOM   1435 C  C   . GLY A 1 235 ? 150.658 139.406 136.848 1.00 43.28  ? 200  GLY A C   1 
ATOM   1436 O  O   . GLY A 1 235 ? 150.357 140.179 137.764 1.00 43.28  ? 200  GLY A O   1 
ATOM   1437 N  N   . LEU A 1 236 ? 149.736 138.787 136.105 1.00 46.43  ? 201  LEU A N   1 
ATOM   1438 C  CA  . LEU A 1 236 ? 148.317 138.967 136.390 1.00 46.43  ? 201  LEU A CA  1 
ATOM   1439 C  C   . LEU A 1 236 ? 147.959 138.422 137.766 1.00 46.43  ? 201  LEU A C   1 
ATOM   1440 O  O   . LEU A 1 236 ? 147.159 139.023 138.490 1.00 46.43  ? 201  LEU A O   1 
ATOM   1441 C  CB  . LEU A 1 236 ? 147.472 138.293 135.311 1.00 46.43  ? 201  LEU A CB  1 
ATOM   1442 C  CG  . LEU A 1 236 ? 146.907 139.230 134.246 1.00 46.43  ? 201  LEU A CG  1 
ATOM   1443 C  CD1 . LEU A 1 236 ? 146.231 138.441 133.139 1.00 46.43  ? 201  LEU A CD1 1 
ATOM   1444 C  CD2 . LEU A 1 236 ? 145.938 140.218 134.873 1.00 46.43  ? 201  LEU A CD2 1 
ATOM   1445 N  N   . LEU A 1 237 ? 148.549 137.287 138.145 1.00 46.26  ? 202  LEU A N   1 
ATOM   1446 C  CA  . LEU A 1 237 ? 148.314 136.735 139.474 1.00 46.26  ? 202  LEU A CA  1 
ATOM   1447 C  C   . LEU A 1 237 ? 148.869 137.653 140.558 1.00 46.26  ? 202  LEU A C   1 
ATOM   1448 O  O   . LEU A 1 237 ? 148.220 137.877 141.589 1.00 46.26  ? 202  LEU A O   1 
ATOM   1449 C  CB  . LEU A 1 237 ? 148.940 135.347 139.573 1.00 46.26  ? 202  LEU A CB  1 
ATOM   1450 C  CG  . LEU A 1 237 ? 148.751 134.574 140.872 1.00 46.26  ? 202  LEU A CG  1 
ATOM   1451 C  CD1 . LEU A 1 237 ? 147.277 134.519 141.228 1.00 46.26  ? 202  LEU A CD1 1 
ATOM   1452 C  CD2 . LEU A 1 237 ? 149.332 133.180 140.737 1.00 46.26  ? 202  LEU A CD2 1 
ATOM   1453 N  N   . THR A 1 238 ? 150.070 138.199 140.337 1.00 44.75  ? 203  THR A N   1 
ATOM   1454 C  CA  . THR A 1 238 ? 150.666 139.107 141.312 1.00 44.75  ? 203  THR A CA  1 
ATOM   1455 C  C   . THR A 1 238 ? 149.820 140.361 141.479 1.00 44.75  ? 203  THR A C   1 
ATOM   1456 O  O   . THR A 1 238 ? 149.710 140.903 142.585 1.00 44.75  ? 203  THR A O   1 
ATOM   1457 C  CB  . THR A 1 238 ? 152.091 139.472 140.893 1.00 44.75  ? 203  THR A CB  1 
ATOM   1458 O  OG1 . THR A 1 238 ? 152.785 138.292 140.471 1.00 44.75  ? 203  THR A OG1 1 
ATOM   1459 C  CG2 . THR A 1 238 ? 152.846 140.091 142.055 1.00 44.75  ? 203  THR A CG2 1 
ATOM   1460 N  N   . PHE A 1 239 ? 149.215 140.842 140.391 1.00 42.18  ? 204  PHE A N   1 
ATOM   1461 C  CA  . PHE A 1 239 ? 148.287 141.962 140.514 1.00 42.18  ? 204  PHE A CA  1 
ATOM   1462 C  C   . PHE A 1 239 ? 147.013 141.554 141.247 1.00 42.18  ? 204  PHE A C   1 
ATOM   1463 O  O   . PHE A 1 239 ? 146.502 142.313 142.078 1.00 42.18  ? 204  PHE A O   1 
ATOM   1464 C  CB  . PHE A 1 239 ? 147.952 142.534 139.138 1.00 42.18  ? 204  PHE A CB  1 
ATOM   1465 C  CG  . PHE A 1 239 ? 146.892 143.593 139.172 1.00 42.18  ? 204  PHE A CG  1 
ATOM   1466 C  CD1 . PHE A 1 239 ? 147.197 144.878 139.580 1.00 42.18  ? 204  PHE A CD1 1 
ATOM   1467 C  CD2 . PHE A 1 239 ? 145.592 143.306 138.793 1.00 42.18  ? 204  PHE A CD2 1 
ATOM   1468 C  CE1 . PHE A 1 239 ? 146.227 145.857 139.618 1.00 42.18  ? 204  PHE A CE1 1 
ATOM   1469 C  CE2 . PHE A 1 239 ? 144.617 144.281 138.828 1.00 42.18  ? 204  PHE A CE2 1 
ATOM   1470 C  CZ  . PHE A 1 239 ? 144.936 145.559 139.240 1.00 42.18  ? 204  PHE A CZ  1 
ATOM   1471 N  N   . PHE A 1 240 ? 146.481 140.365 140.948 1.00 52.62  ? 205  PHE A N   1 
ATOM   1472 C  CA  . PHE A 1 240 ? 145.239 139.908 141.566 1.00 52.62  ? 205  PHE A CA  1 
ATOM   1473 C  C   . PHE A 1 240 ? 145.399 139.614 143.051 1.00 52.62  ? 205  PHE A C   1 
ATOM   1474 O  O   . PHE A 1 240 ? 144.393 139.482 143.755 1.00 52.62  ? 205  PHE A O   1 
ATOM   1475 C  CB  . PHE A 1 240 ? 144.723 138.657 140.852 1.00 52.62  ? 205  PHE A CB  1 
ATOM   1476 C  CG  . PHE A 1 240 ? 143.830 138.949 139.680 1.00 52.62  ? 205  PHE A CG  1 
ATOM   1477 C  CD1 . PHE A 1 240 ? 143.716 140.235 139.177 1.00 52.62  ? 205  PHE A CD1 1 
ATOM   1478 C  CD2 . PHE A 1 240 ? 143.110 137.933 139.076 1.00 52.62  ? 205  PHE A CD2 1 
ATOM   1479 C  CE1 . PHE A 1 240 ? 142.897 140.502 138.097 1.00 52.62  ? 205  PHE A CE1 1 
ATOM   1480 C  CE2 . PHE A 1 240 ? 142.290 138.194 137.996 1.00 52.62  ? 205  PHE A CE2 1 
ATOM   1481 C  CZ  . PHE A 1 240 ? 142.183 139.480 137.506 1.00 52.62  ? 205  PHE A CZ  1 
ATOM   1482 N  N   . PHE A 1 241 ? 146.637 139.464 143.525 1.00 46.57  ? 206  PHE A N   1 
ATOM   1483 C  CA  . PHE A 1 241 ? 146.874 139.327 144.961 1.00 46.57  ? 206  PHE A CA  1 
ATOM   1484 C  C   . PHE A 1 241 ? 146.368 140.534 145.750 1.00 46.57  ? 206  PHE A C   1 
ATOM   1485 O  O   . PHE A 1 241 ? 145.918 140.380 146.890 1.00 46.57  ? 206  PHE A O   1 
ATOM   1486 C  CB  . PHE A 1 241 ? 148.365 139.115 145.223 1.00 46.57  ? 206  PHE A CB  1 
ATOM   1487 C  CG  . PHE A 1 241 ? 148.790 137.673 145.232 1.00 46.57  ? 206  PHE A CG  1 
ATOM   1488 C  CD1 . PHE A 1 241 ? 148.189 136.746 144.400 1.00 46.57  ? 206  PHE A CD1 1 
ATOM   1489 C  CD2 . PHE A 1 241 ? 149.829 137.255 146.043 1.00 46.57  ? 206  PHE A CD2 1 
ATOM   1490 C  CE1 . PHE A 1 241 ? 148.594 135.427 144.404 1.00 46.57  ? 206  PHE A CE1 1 
ATOM   1491 C  CE2 . PHE A 1 241 ? 150.239 135.940 146.042 1.00 46.57  ? 206  PHE A CE2 1 
ATOM   1492 C  CZ  . PHE A 1 241 ? 149.620 135.024 145.224 1.00 46.57  ? 206  PHE A CZ  1 
ATOM   1493 N  N   . PHE A 1 242 ? 146.451 141.741 145.171 1.00 46.27  ? 207  PHE A N   1 
ATOM   1494 C  CA  . PHE A 1 242 ? 146.054 142.946 145.904 1.00 46.27  ? 207  PHE A CA  1 
ATOM   1495 C  C   . PHE A 1 242 ? 144.559 143.001 146.227 1.00 46.27  ? 207  PHE A C   1 
ATOM   1496 O  O   . PHE A 1 242 ? 144.216 143.372 147.367 1.00 46.27  ? 207  PHE A O   1 
ATOM   1497 C  CB  . PHE A 1 242 ? 146.534 144.190 145.146 1.00 46.27  ? 207  PHE A CB  1 
ATOM   1498 C  CG  . PHE A 1 242 ? 145.791 145.444 145.499 1.00 46.27  ? 207  PHE A CG  1 
ATOM   1499 C  CD1 . PHE A 1 242 ? 146.002 146.069 146.715 1.00 46.27  ? 207  PHE A CD1 1 
ATOM   1500 C  CD2 . PHE A 1 242 ? 144.883 145.999 144.614 1.00 46.27  ? 207  PHE A CD2 1 
ATOM   1501 C  CE1 . PHE A 1 242 ? 145.325 147.226 147.041 1.00 46.27  ? 207  PHE A CE1 1 
ATOM   1502 C  CE2 . PHE A 1 242 ? 144.200 147.153 144.936 1.00 46.27  ? 207  PHE A CE2 1 
ATOM   1503 C  CZ  . PHE A 1 242 ? 144.421 147.767 146.150 1.00 46.27  ? 207  PHE A CZ  1 
ATOM   1504 N  N   . PRO A 1 243 ? 143.625 142.699 145.305 1.00 52.99  ? 208  PRO A N   1 
ATOM   1505 C  CA  . PRO A 1 243 ? 142.211 142.644 145.723 1.00 52.99  ? 208  PRO A CA  1 
ATOM   1506 C  C   . PRO A 1 243 ? 141.937 141.625 146.813 1.00 52.99  ? 208  PRO A C   1 
ATOM   1507 O  O   . PRO A 1 243 ? 141.009 141.823 147.604 1.00 52.99  ? 208  PRO A O   1 
ATOM   1508 C  CB  . PRO A 1 243 ? 141.464 142.292 144.431 1.00 52.99  ? 208  PRO A CB  1 
ATOM   1509 C  CG  . PRO A 1 243 ? 142.335 142.718 143.346 1.00 52.99  ? 208  PRO A CG  1 
ATOM   1510 C  CD  . PRO A 1 243 ? 143.744 142.646 143.833 1.00 52.99  ? 208  PRO A CD  1 
ATOM   1511 N  N   . ILE A 1 244 ? 142.717 140.544 146.883 1.00 58.17  ? 209  ILE A N   1 
ATOM   1512 C  CA  . ILE A 1 244 ? 142.594 139.612 148.002 1.00 58.17  ? 209  ILE A CA  1 
ATOM   1513 C  C   . ILE A 1 244 ? 142.951 140.308 149.309 1.00 58.17  ? 209  ILE A C   1 
ATOM   1514 O  O   . ILE A 1 244 ? 142.298 140.100 150.340 1.00 58.17  ? 209  ILE A O   1 
ATOM   1515 C  CB  . ILE A 1 244 ? 143.464 138.362 147.764 1.00 58.17  ? 209  ILE A CB  1 
ATOM   1516 C  CG1 . ILE A 1 244 ? 143.174 137.729 146.397 1.00 58.17  ? 209  ILE A CG1 1 
ATOM   1517 C  CG2 . ILE A 1 244 ? 143.254 137.343 148.874 1.00 58.17  ? 209  ILE A CG2 1 
ATOM   1518 C  CD1 . ILE A 1 244 ? 141.695 137.576 146.060 1.00 58.17  ? 209  ILE A CD1 1 
ATOM   1519 N  N   . CYS A 1 245 ? 143.987 141.152 149.285 1.00 57.43  ? 210  CYS A N   1 
ATOM   1520 C  CA  . CYS A 1 245 ? 144.349 141.923 150.470 1.00 57.43  ? 210  CYS A CA  1 
ATOM   1521 C  C   . CYS A 1 245 ? 143.237 142.886 150.865 1.00 57.43  ? 210  CYS A C   1 
ATOM   1522 O  O   . CYS A 1 245 ? 142.920 143.024 152.053 1.00 57.43  ? 210  CYS A O   1 
ATOM   1523 C  CB  . CYS A 1 245 ? 145.653 142.682 150.228 1.00 57.43  ? 210  CYS A CB  1 
ATOM   1524 S  SG  . CYS A 1 245 ? 146.365 143.426 151.711 1.00 57.43  ? 210  CYS A SG  1 
ATOM   1525 N  N   . VAL A 1 246 ? 142.672 143.611 149.889 1.00 56.44  ? 211  VAL A N   1 
ATOM   1526 C  CA  . VAL A 1 246 ? 141.647 144.639 150.257 1.00 56.44  ? 211  VAL A CA  1 
ATOM   1527 C  C   . VAL A 1 246 ? 140.352 143.950 150.697 1.00 56.44  ? 211  VAL A C   1 
ATOM   1528 O  O   . VAL A 1 246 ? 139.713 144.469 151.625 1.00 56.44  ? 211  VAL A O   1 
ATOM   1529 C  CB  . VAL A 1 246 ? 141.405 145.723 149.190 1.00 56.44  ? 211  VAL A CB  1 
ATOM   1530 C  CG1 . VAL A 1 246 ? 142.571 146.689 149.095 1.00 56.44  ? 211  VAL A CG1 1 
ATOM   1531 C  CG2 . VAL A 1 246 ? 141.052 145.157 147.828 1.00 56.44  ? 211  VAL A CG2 1 
ATOM   1532 N  N   . VAL A 1 247 ? 139.971 142.836 150.064 1.00 66.65  ? 212  VAL A N   1 
ATOM   1533 C  CA  . VAL A 1 247 ? 138.777 142.093 150.562 1.00 66.65  ? 212  VAL A CA  1 
ATOM   1534 C  C   . VAL A 1 247 ? 139.097 141.569 151.963 1.00 66.65  ? 212  VAL A C   1 
ATOM   1535 O  O   . VAL A 1 247 ? 138.200 141.616 152.816 1.00 66.65  ? 212  VAL A O   1 
ATOM   1536 C  CB  . VAL A 1 247 ? 138.256 140.998 149.610 1.00 66.65  ? 212  VAL A CB  1 
ATOM   1537 C  CG1 . VAL A 1 247 ? 137.876 141.548 148.245 1.00 66.65  ? 212  VAL A CG1 1 
ATOM   1538 C  CG2 . VAL A 1 247 ? 139.184 139.802 149.491 1.00 66.65  ? 212  VAL A CG2 1 
ATOM   1539 N  N   . PHE A 1 248 ? 140.334 141.120 152.197 1.00 73.92  ? 213  PHE A N   1 
ATOM   1540 C  CA  . PHE A 1 248 ? 140.724 140.666 153.557 1.00 73.92  ? 213  PHE A CA  1 
ATOM   1541 C  C   . PHE A 1 248 ? 140.617 141.837 154.534 1.00 73.92  ? 213  PHE A C   1 
ATOM   1542 O  O   . PHE A 1 248 ? 140.142 141.626 155.659 1.00 73.92  ? 213  PHE A O   1 
ATOM   1543 C  CB  . PHE A 1 248 ? 142.144 140.098 153.583 1.00 73.92  ? 213  PHE A CB  1 
ATOM   1544 C  CG  . PHE A 1 248 ? 142.261 138.658 153.154 1.00 73.92  ? 213  PHE A CG  1 
ATOM   1545 C  CD1 . PHE A 1 248 ? 141.133 137.910 152.855 1.00 73.92  ? 213  PHE A CD1 1 
ATOM   1546 C  CD2 . PHE A 1 248 ? 143.500 138.047 153.052 1.00 73.92  ? 213  PHE A CD2 1 
ATOM   1547 C  CE1 . PHE A 1 248 ? 141.242 136.586 152.461 1.00 73.92  ? 213  PHE A CE1 1 
ATOM   1548 C  CE2 . PHE A 1 248 ? 143.609 136.723 152.660 1.00 73.92  ? 213  PHE A CE2 1 
ATOM   1549 C  CZ  . PHE A 1 248 ? 142.480 135.995 152.366 1.00 73.92  ? 213  PHE A CZ  1 
ATOM   1550 N  N   . ALA A 1 249 ? 141.041 143.030 154.114 1.00 70.37  ? 214  ALA A N   1 
ATOM   1551 C  CA  . ALA A 1 249 ? 140.934 144.217 154.989 1.00 70.37  ? 214  ALA A CA  1 
ATOM   1552 C  C   . ALA A 1 249 ? 139.459 144.510 155.284 1.00 70.37  ? 214  ALA A C   1 
ATOM   1553 O  O   . ALA A 1 249 ? 139.130 144.752 156.454 1.00 70.37  ? 214  ALA A O   1 
ATOM   1554 C  CB  . ALA A 1 249 ? 141.609 145.395 154.343 1.00 70.37  ? 214  ALA A CB  1 
ATOM   1555 N  N   . TRP A 1 250 ? 138.598 144.447 154.267 1.00 83.69  ? 215  TRP A N   1 
ATOM   1556 C  CA  . TRP A 1 250 ? 137.163 144.772 154.471 1.00 83.69  ? 215  TRP A CA  1 
ATOM   1557 C  C   . TRP A 1 250 ? 136.556 143.742 155.424 1.00 83.69  ? 215  TRP A C   1 
ATOM   1558 O  O   . TRP A 1 250 ? 135.849 144.149 156.362 1.00 83.69  ? 215  TRP A O   1 
ATOM   1559 C  CB  . TRP A 1 250 ? 136.420 144.812 153.133 1.00 83.69  ? 215  TRP A CB  1 
ATOM   1560 C  CG  . TRP A 1 250 ? 134.939 144.973 153.266 1.00 83.69  ? 215  TRP A CG  1 
ATOM   1561 C  CD1 . TRP A 1 250 ? 134.252 146.132 153.482 1.00 83.69  ? 215  TRP A CD1 1 
ATOM   1562 C  CD2 . TRP A 1 250 ? 133.951 143.931 153.188 1.00 83.69  ? 215  TRP A CD2 1 
ATOM   1563 N  NE1 . TRP A 1 250 ? 132.908 145.883 153.546 1.00 83.69  ? 215  TRP A NE1 1 
ATOM   1564 C  CE2 . TRP A 1 250 ? 132.693 144.542 153.371 1.00 83.69  ? 215  TRP A CE2 1 
ATOM   1565 C  CE3 . TRP A 1 250 ? 134.007 142.548 152.986 1.00 83.69  ? 215  TRP A CE3 1 
ATOM   1566 C  CZ2 . TRP A 1 250 ? 131.504 143.814 153.355 1.00 83.69  ? 215  TRP A CZ2 1 
ATOM   1567 C  CZ3 . TRP A 1 250 ? 132.832 141.830 152.971 1.00 83.69  ? 215  TRP A CZ3 1 
ATOM   1568 C  CH2 . TRP A 1 250 ? 131.600 142.457 153.153 1.00 83.69  ? 215  TRP A CH2 1 
ATOM   1569 N  N   . VAL A 1 251 ? 136.835 142.460 155.187 1.00 85.16  ? 216  VAL A N   1 
ATOM   1570 C  CA  . VAL A 1 251 ? 136.308 141.377 156.066 1.00 85.16  ? 216  VAL A CA  1 
ATOM   1571 C  C   . VAL A 1 251 ? 136.797 141.653 157.487 1.00 85.16  ? 216  VAL A C   1 
ATOM   1572 O  O   . VAL A 1 251 ? 135.964 141.622 158.409 1.00 85.16  ? 216  VAL A O   1 
ATOM   1573 C  CB  . VAL A 1 251 ? 136.764 139.988 155.580 1.00 85.16  ? 216  VAL A CB  1 
ATOM   1574 C  CG1 . VAL A 1 251 ? 136.645 138.928 156.664 1.00 85.16  ? 216  VAL A CG1 1 
ATOM   1575 C  CG2 . VAL A 1 251 ? 136.026 139.557 154.323 1.00 85.16  ? 216  VAL A CG2 1 
ATOM   1576 N  N   . ALA A 1 252 ? 138.087 141.951 157.644 1.00 83.48  ? 217  ALA A N   1 
ATOM   1577 C  CA  . ALA A 1 252 ? 138.655 142.135 158.998 1.00 83.48  ? 217  ALA A CA  1 
ATOM   1578 C  C   . ALA A 1 252 ? 137.974 143.318 159.685 1.00 83.48  ? 217  ALA A C   1 
ATOM   1579 O  O   . ALA A 1 252 ? 137.647 143.190 160.873 1.00 83.48  ? 217  ALA A O   1 
ATOM   1580 C  CB  . ALA A 1 252 ? 140.145 142.332 158.924 1.00 83.48  ? 217  ALA A CB  1 
ATOM   1581 N  N   . ASP A 1 253 ? 137.759 144.418 158.960 1.00 80.20  ? 218  ASP A N   1 
ATOM   1582 C  CA  . ASP A 1 253 ? 137.175 145.628 159.596 1.00 80.20  ? 218  ASP A CA  1 
ATOM   1583 C  C   . ASP A 1 253 ? 135.765 145.299 160.091 1.00 80.20  ? 218  ASP A C   1 
ATOM   1584 O  O   . ASP A 1 253 ? 135.452 145.634 161.250 1.00 80.20  ? 218  ASP A O   1 
ATOM   1585 C  CB  . ASP A 1 253 ? 137.150 146.804 158.619 1.00 80.20  ? 218  ASP A CB  1 
ATOM   1586 C  CG  . ASP A 1 253 ? 136.695 148.109 159.246 1.00 80.20  ? 218  ASP A CG  1 
ATOM   1587 O  OD1 . ASP A 1 253 ? 136.892 148.273 160.466 1.00 80.20  ? 218  ASP A OD1 1 
ATOM   1588 O  OD2 . ASP A 1 253 ? 136.144 148.948 158.508 1.00 80.20  ? 218  ASP A OD2 1 
ATOM   1589 N  N   . ARG A 1 254 ? 134.968 144.626 159.258 1.00 92.74  ? 219  ARG A N   1 
ATOM   1590 C  CA  . ARG A 1 254 ? 133.567 144.325 159.646 1.00 92.74  ? 219  ARG A CA  1 
ATOM   1591 C  C   . ARG A 1 254 ? 133.589 143.401 160.864 1.00 92.74  ? 219  ARG A C   1 
ATOM   1592 O  O   . ARG A 1 254 ? 132.865 143.686 161.836 1.00 92.74  ? 219  ARG A O   1 
ATOM   1593 C  CB  . ARG A 1 254 ? 132.843 143.654 158.477 1.00 92.74  ? 219  ARG A CB  1 
ATOM   1594 C  CG  . ARG A 1 254 ? 131.347 143.470 158.686 1.00 92.74  ? 219  ARG A CG  1 
ATOM   1595 C  CD  . ARG A 1 254 ? 130.577 144.756 158.464 1.00 92.74  ? 219  ARG A CD  1 
ATOM   1596 N  NE  . ARG A 1 254 ? 130.680 145.230 157.091 1.00 92.74  ? 219  ARG A NE  1 
ATOM   1597 C  CZ  . ARG A 1 254 ? 130.066 146.310 156.621 1.00 92.74  ? 219  ARG A CZ  1 
ATOM   1598 N  NH1 . ARG A 1 254 ? 129.300 147.034 157.419 1.00 92.74  ? 219  ARG A NH1 1 
ATOM   1599 N  NH2 . ARG A 1 254 ? 130.219 146.663 155.358 1.00 92.74  ? 219  ARG A NH2 1 
ATOM   1600 N  N   . ARG A 1 255 ? 134.433 142.367 160.828 1.00 97.91  ? 220  ARG A N   1 
ATOM   1601 C  CA  . ARG A 1 255 ? 134.485 141.384 161.942 1.00 97.91  ? 220  ARG A CA  1 
ATOM   1602 C  C   . ARG A 1 255 ? 134.982 142.064 163.219 1.00 97.91  ? 220  ARG A C   1 
ATOM   1603 O  O   . ARG A 1 255 ? 134.352 141.862 164.266 1.00 97.91  ? 220  ARG A O   1 
ATOM   1604 C  CB  . ARG A 1 255 ? 135.381 140.206 161.553 1.00 97.91  ? 220  ARG A CB  1 
ATOM   1605 C  CG  . ARG A 1 255 ? 135.562 139.160 162.642 1.00 97.91  ? 220  ARG A CG  1 
ATOM   1606 C  CD  . ARG A 1 255 ? 135.859 137.803 162.033 1.00 97.91  ? 220  ARG A CD  1 
ATOM   1607 N  NE  . ARG A 1 255 ? 136.912 137.872 161.030 1.00 97.91  ? 220  ARG A NE  1 
ATOM   1608 C  CZ  . ARG A 1 255 ? 138.186 137.573 161.253 1.00 97.91  ? 220  ARG A CZ  1 
ATOM   1609 N  NH1 . ARG A 1 255 ? 139.068 137.669 160.274 1.00 97.91  ? 220  ARG A NH1 1 
ATOM   1610 N  NH2 . ARG A 1 255 ? 138.570 137.169 162.451 1.00 97.91  ? 220  ARG A NH2 1 
ATOM   1611 N  N   . LEU A 1 256 ? 136.036 142.877 163.126 1.00 94.50  ? 221  LEU A N   1 
ATOM   1612 C  CA  . LEU A 1 256 ? 136.620 143.479 164.354 1.00 94.50  ? 221  LEU A CA  1 
ATOM   1613 C  C   . LEU A 1 256 ? 135.599 144.408 165.020 1.00 94.50  ? 221  LEU A C   1 
ATOM   1614 O  O   . LEU A 1 256 ? 135.449 144.329 166.255 1.00 94.50  ? 221  LEU A O   1 
ATOM   1615 C  CB  . LEU A 1 256 ? 137.890 144.245 163.972 1.00 94.50  ? 221  LEU A CB  1 
ATOM   1616 C  CG  . LEU A 1 256 ? 138.804 144.633 165.131 1.00 94.50  ? 221  LEU A CG  1 
ATOM   1617 C  CD1 . LEU A 1 256 ? 139.196 143.406 165.938 1.00 94.50  ? 221  LEU A CD1 1 
ATOM   1618 C  CD2 . LEU A 1 256 ? 140.042 145.349 164.615 1.00 94.50  ? 221  LEU A CD2 1 
ATOM   1619 N  N   . LEU A 1 257 ? 134.928 145.255 164.234 1.00 94.05  ? 222  LEU A N   1 
ATOM   1620 C  CA  . LEU A 1 257 ? 133.971 146.227 164.823 1.00 94.05  ? 222  LEU A CA  1 
ATOM   1621 C  C   . LEU A 1 257 ? 132.770 145.489 165.422 1.00 94.05  ? 222  LEU A C   1 
ATOM   1622 O  O   . LEU A 1 257 ? 132.398 145.803 166.568 1.00 94.05  ? 222  LEU A O   1 
ATOM   1623 C  CB  . LEU A 1 257 ? 133.517 147.184 163.717 1.00 94.05  ? 222  LEU A CB  1 
ATOM   1624 C  CG  . LEU A 1 257 ? 132.595 148.318 164.160 1.00 94.05  ? 222  LEU A CG  1 
ATOM   1625 C  CD1 . LEU A 1 257 ? 133.307 149.246 165.132 1.00 94.05  ? 222  LEU A CD1 1 
ATOM   1626 C  CD2 . LEU A 1 257 ? 132.088 149.099 162.957 1.00 94.05  ? 222  LEU A CD2 1 
ATOM   1627 N  N   . PHE A 1 258 ? 132.193 144.541 164.678 1.00 103.59 ? 223  PHE A N   1 
ATOM   1628 C  CA  . PHE A 1 258 ? 130.973 143.837 165.157 1.00 103.59 ? 223  PHE A CA  1 
ATOM   1629 C  C   . PHE A 1 258 ? 131.274 142.931 166.354 1.00 103.59 ? 223  PHE A C   1 
ATOM   1630 O  O   . PHE A 1 258 ? 130.501 142.964 167.331 1.00 103.59 ? 223  PHE A O   1 
ATOM   1631 C  CB  . PHE A 1 258 ? 130.335 143.041 164.014 1.00 103.59 ? 223  PHE A CB  1 
ATOM   1632 C  CG  . PHE A 1 258 ? 129.185 142.156 164.424 1.00 103.59 ? 223  PHE A CG  1 
ATOM   1633 C  CD1 . PHE A 1 258 ? 127.952 142.699 164.745 1.00 103.59 ? 223  PHE A CD1 1 
ATOM   1634 C  CD2 . PHE A 1 258 ? 129.334 140.780 164.485 1.00 103.59 ? 223  PHE A CD2 1 
ATOM   1635 C  CE1 . PHE A 1 258 ? 126.895 141.885 165.124 1.00 103.59 ? 223  PHE A CE1 1 
ATOM   1636 C  CE2 . PHE A 1 258 ? 128.278 139.967 164.865 1.00 103.59 ? 223  PHE A CE2 1 
ATOM   1637 C  CZ  . PHE A 1 258 ? 127.060 140.521 165.182 1.00 103.59 ? 223  PHE A CZ  1 
ATOM   1638 N  N   . TYR A 1 259 ? 132.363 142.160 166.291 1.00 105.72 ? 224  TYR A N   1 
ATOM   1639 C  CA  . TYR A 1 259 ? 132.640 141.168 167.365 1.00 105.72 ? 224  TYR A CA  1 
ATOM   1640 C  C   . TYR A 1 259 ? 132.902 141.856 168.705 1.00 105.72 ? 224  TYR A C   1 
ATOM   1641 O  O   . TYR A 1 259 ? 132.357 141.390 169.724 1.00 105.72 ? 224  TYR A O   1 
ATOM   1642 C  CB  . TYR A 1 259 ? 133.819 140.267 166.985 1.00 105.72 ? 224  TYR A CB  1 
ATOM   1643 C  CG  . TYR A 1 259 ? 133.462 139.072 166.137 1.00 105.72 ? 224  TYR A CG  1 
ATOM   1644 C  CD1 . TYR A 1 259 ? 132.531 139.167 165.116 1.00 105.72 ? 224  TYR A CD1 1 
ATOM   1645 C  CD2 . TYR A 1 259 ? 134.066 137.844 166.349 1.00 105.72 ? 224  TYR A CD2 1 
ATOM   1646 C  CE1 . TYR A 1 259 ? 132.202 138.073 164.333 1.00 105.72 ? 224  TYR A CE1 1 
ATOM   1647 C  CE2 . TYR A 1 259 ? 133.750 136.741 165.574 1.00 105.72 ? 224  TYR A CE2 1 
ATOM   1648 C  CZ  . TYR A 1 259 ? 132.814 136.855 164.562 1.00 105.72 ? 224  TYR A CZ  1 
ATOM   1649 O  OH  . TYR A 1 259 ? 132.498 135.772 163.794 1.00 105.72 ? 224  TYR A OH  1 
ATOM   1650 N  N   . LYS A 1 260 ? 133.699 142.927 168.706 1.00 105.47 ? 225  LYS A N   1 
ATOM   1651 C  CA  . LYS A 1 260 ? 134.072 143.563 169.997 1.00 105.47 ? 225  LYS A CA  1 
ATOM   1652 C  C   . LYS A 1 260 ? 133.715 145.048 169.963 1.00 105.47 ? 225  LYS A C   1 
ATOM   1653 O  O   . LYS A 1 260 ? 134.112 145.717 168.992 1.00 105.47 ? 225  LYS A O   1 
ATOM   1654 C  CB  . LYS A 1 260 ? 135.578 143.413 170.237 1.00 105.47 ? 225  LYS A CB  1 
ATOM   1655 C  CG  . LYS A 1 260 ? 136.126 141.995 170.140 1.00 105.47 ? 225  LYS A CG  1 
ATOM   1656 C  CD  . LYS A 1 260 ? 135.553 141.053 171.178 1.00 105.47 ? 225  LYS A CD  1 
ATOM   1657 C  CE  . LYS A 1 260 ? 136.092 139.643 171.061 1.00 105.47 ? 225  LYS A CE  1 
ATOM   1658 N  NZ  . LYS A 1 260 ? 137.565 139.605 171.214 1.00 105.47 ? 225  LYS A NZ  1 
ATOM   1659 N  N   . TYR A 1 261 ? 133.009 145.547 170.981 1.00 90.80  ? 226  TYR A N   1 
ATOM   1660 C  CA  . TYR A 1 261 ? 132.764 147.011 171.028 1.00 90.80  ? 226  TYR A CA  1 
ATOM   1661 C  C   . TYR A 1 261 ? 134.109 147.698 171.276 1.00 90.80  ? 226  TYR A C   1 
ATOM   1662 O  O   . TYR A 1 261 ? 134.887 147.205 172.116 1.00 90.80  ? 226  TYR A O   1 
ATOM   1663 C  CB  . TYR A 1 261 ? 131.753 147.391 172.114 1.00 90.80  ? 226  TYR A CB  1 
ATOM   1664 C  CG  . TYR A 1 261 ? 131.617 148.881 172.309 1.00 90.80  ? 226  TYR A CG  1 
ATOM   1665 C  CD1 . TYR A 1 261 ? 131.019 149.674 171.344 1.00 90.80  ? 226  TYR A CD1 1 
ATOM   1666 C  CD2 . TYR A 1 261 ? 132.109 149.505 173.443 1.00 90.80  ? 226  TYR A CD2 1 
ATOM   1667 C  CE1 . TYR A 1 261 ? 130.902 151.045 171.503 1.00 90.80  ? 226  TYR A CE1 1 
ATOM   1668 C  CE2 . TYR A 1 261 ? 132.002 150.875 173.618 1.00 90.80  ? 226  TYR A CE2 1 
ATOM   1669 C  CZ  . TYR A 1 261 ? 131.394 151.648 172.645 1.00 90.80  ? 226  TYR A CZ  1 
ATOM   1670 O  OH  . TYR A 1 261 ? 131.281 152.998 172.811 1.00 90.80  ? 226  TYR A OH  1 
ATOM   1671 N  N   . VAL A 1 262 ? 134.367 148.804 170.576 1.00 83.16  ? 227  VAL A N   1 
ATOM   1672 C  CA  . VAL A 1 262 ? 135.674 149.503 170.721 1.00 83.16  ? 227  VAL A CA  1 
ATOM   1673 C  C   . VAL A 1 262 ? 135.418 150.883 171.328 1.00 83.16  ? 227  VAL A C   1 
ATOM   1674 O  O   . VAL A 1 262 ? 134.525 151.590 170.831 1.00 83.16  ? 227  VAL A O   1 
ATOM   1675 C  CB  . VAL A 1 262 ? 136.417 149.591 169.374 1.00 83.16  ? 227  VAL A CB  1 
ATOM   1676 C  CG1 . VAL A 1 262 ? 137.017 148.251 168.979 1.00 83.16  ? 227  VAL A CG1 1 
ATOM   1677 C  CG2 . VAL A 1 262 ? 135.530 150.122 168.259 1.00 83.16  ? 227  VAL A CG2 1 
ATOM   1678 N  N   . TYR A 1 263 ? 136.146 151.234 172.388 1.00 70.19  ? 228  TYR A N   1 
ATOM   1679 C  CA  . TYR A 1 263 ? 136.000 152.605 172.937 1.00 70.19  ? 228  TYR A CA  1 
ATOM   1680 C  C   . TYR A 1 263 ? 136.596 153.563 171.913 1.00 70.19  ? 228  TYR A C   1 
ATOM   1681 O  O   . TYR A 1 263 ? 137.697 153.284 171.421 1.00 70.19  ? 228  TYR A O   1 
ATOM   1682 C  CB  . TYR A 1 263 ? 136.646 152.735 174.315 1.00 70.19  ? 228  TYR A CB  1 
ATOM   1683 C  CG  . TYR A 1 263 ? 136.427 154.066 174.988 1.00 70.19  ? 228  TYR A CG  1 
ATOM   1684 C  CD1 . TYR A 1 263 ? 135.177 154.430 175.458 1.00 70.19  ? 228  TYR A CD1 1 
ATOM   1685 C  CD2 . TYR A 1 263 ? 137.470 154.959 175.164 1.00 70.19  ? 228  TYR A CD2 1 
ATOM   1686 C  CE1 . TYR A 1 263 ? 134.967 155.647 176.082 1.00 70.19  ? 228  TYR A CE1 1 
ATOM   1687 C  CE2 . TYR A 1 263 ? 137.278 156.180 175.788 1.00 70.19  ? 228  TYR A CE2 1 
ATOM   1688 C  CZ  . TYR A 1 263 ? 136.021 156.526 176.248 1.00 70.19  ? 228  TYR A CZ  1 
ATOM   1689 O  OH  . TYR A 1 263 ? 135.822 157.726 176.864 1.00 70.19  ? 228  TYR A OH  1 
ATOM   1690 N  N   . LYS A 1 264 ? 135.890 154.644 171.601 1.00 56.93  ? 229  LYS A N   1 
ATOM   1691 C  CA  . LYS A 1 264 ? 136.336 155.555 170.555 1.00 56.93  ? 229  LYS A CA  1 
ATOM   1692 C  C   . LYS A 1 264 ? 136.810 156.865 171.170 1.00 56.93  ? 229  LYS A C   1 
ATOM   1693 O  O   . LYS A 1 264 ? 136.132 157.428 172.035 1.00 56.93  ? 229  LYS A O   1 
ATOM   1694 C  CB  . LYS A 1 264 ? 135.207 155.821 169.559 1.00 56.93  ? 229  LYS A CB  1 
ATOM   1695 C  CG  . LYS A 1 264 ? 134.733 154.582 168.821 1.00 56.93  ? 229  LYS A CG  1 
ATOM   1696 C  CD  . LYS A 1 264 ? 133.448 154.851 168.055 1.00 56.93  ? 229  LYS A CD  1 
ATOM   1697 C  CE  . LYS A 1 264 ? 132.849 153.562 167.518 1.00 56.93  ? 229  LYS A CE  1 
ATOM   1698 N  NZ  . LYS A 1 264 ? 131.493 153.771 166.942 1.00 56.93  ? 229  LYS A NZ  1 
ATOM   1699 N  N   . ARG A 1 265 ? 137.964 157.351 170.719 1.00 51.30  ? 230  ARG A N   1 
ATOM   1700 C  CA  . ARG A 1 265 ? 138.506 158.634 171.137 1.00 51.30  ? 230  ARG A CA  1 
ATOM   1701 C  C   . ARG A 1 265 ? 138.743 159.498 169.908 1.00 51.30  ? 230  ARG A C   1 
ATOM   1702 O  O   . ARG A 1 265 ? 139.229 159.012 168.882 1.00 51.30  ? 230  ARG A O   1 
ATOM   1703 C  CB  . ARG A 1 265 ? 139.814 158.459 171.911 1.00 51.30  ? 230  ARG A CB  1 
ATOM   1704 C  CG  . ARG A 1 265 ? 139.697 157.599 173.155 1.00 51.30  ? 230  ARG A CG  1 
ATOM   1705 C  CD  . ARG A 1 265 ? 141.066 157.316 173.748 1.00 51.30  ? 230  ARG A CD  1 
ATOM   1706 N  NE  . ARG A 1 265 ? 141.835 158.536 173.966 1.00 51.30  ? 230  ARG A NE  1 
ATOM   1707 C  CZ  . ARG A 1 265 ? 141.756 159.288 175.054 1.00 51.30  ? 230  ARG A CZ  1 
ATOM   1708 N  NH1 . ARG A 1 265 ? 140.944 158.978 176.052 1.00 51.30  ? 230  ARG A NH1 1 
ATOM   1709 N  NH2 . ARG A 1 265 ? 142.512 160.378 175.145 1.00 51.30  ? 230  ARG A NH2 1 
ATOM   1710 N  N   . TYR A 1 266 ? 138.408 160.779 170.014 1.00 48.60  ? 231  TYR A N   1 
ATOM   1711 C  CA  . TYR A 1 266 ? 138.468 161.702 168.889 1.00 48.60  ? 231  TYR A CA  1 
ATOM   1712 C  C   . TYR A 1 266 ? 139.606 162.692 169.093 1.00 48.60  ? 231  TYR A C   1 
ATOM   1713 O  O   . TYR A 1 266 ? 139.731 163.288 170.167 1.00 48.60  ? 231  TYR A O   1 
ATOM   1714 C  CB  . TYR A 1 266 ? 137.146 162.454 168.719 1.00 48.60  ? 231  TYR A CB  1 
ATOM   1715 C  CG  . TYR A 1 266 ? 135.931 161.565 168.560 1.00 48.60  ? 231  TYR A CG  1 
ATOM   1716 C  CD1 . TYR A 1 266 ? 135.274 161.046 169.669 1.00 48.60  ? 231  TYR A CD1 1 
ATOM   1717 C  CD2 . TYR A 1 266 ? 135.447 161.238 167.303 1.00 48.60  ? 231  TYR A CD2 1 
ATOM   1718 C  CE1 . TYR A 1 266 ? 134.167 160.236 169.529 1.00 48.60  ? 231  TYR A CE1 1 
ATOM   1719 C  CE2 . TYR A 1 266 ? 134.340 160.424 167.153 1.00 48.60  ? 231  TYR A CE2 1 
ATOM   1720 C  CZ  . TYR A 1 266 ? 133.705 159.926 168.271 1.00 48.60  ? 231  TYR A CZ  1 
ATOM   1721 O  OH  . TYR A 1 266 ? 132.602 159.116 168.133 1.00 48.60  ? 231  TYR A OH  1 
ATOM   1722 N  N   . ARG A 1 267 ? 140.433 162.860 168.062 1.00 42.41  ? 232  ARG A N   1 
ATOM   1723 C  CA  . ARG A 1 267 ? 141.516 163.828 168.057 1.00 42.41  ? 232  ARG A CA  1 
ATOM   1724 C  C   . ARG A 1 267 ? 141.403 164.702 166.815 1.00 42.41  ? 232  ARG A C   1 
ATOM   1725 O  O   . ARG A 1 267 ? 140.749 164.345 165.830 1.00 42.41  ? 232  ARG A O   1 
ATOM   1726 C  CB  . ARG A 1 267 ? 142.890 163.143 168.105 1.00 42.41  ? 232  ARG A CB  1 
ATOM   1727 C  CG  . ARG A 1 267 ? 143.354 162.554 166.786 1.00 42.41  ? 232  ARG A CG  1 
ATOM   1728 C  CD  . ARG A 1 267 ? 144.861 162.359 166.786 1.00 42.41  ? 232  ARG A CD  1 
ATOM   1729 N  NE  . ARG A 1 267 ? 145.363 161.888 165.501 1.00 42.41  ? 232  ARG A NE  1 
ATOM   1730 C  CZ  . ARG A 1 267 ? 145.613 160.619 165.214 1.00 42.41  ? 232  ARG A CZ  1 
ATOM   1731 N  NH1 . ARG A 1 267 ? 145.428 159.659 166.104 1.00 42.41  ? 232  ARG A NH1 1 
ATOM   1732 N  NH2 . ARG A 1 267 ? 146.063 160.304 164.004 1.00 42.41  ? 232  ARG A NH2 1 
ATOM   1733 N  N   . ALA A 1 268 ? 142.035 165.870 166.887 1.00 46.55  ? 233  ALA A N   1 
ATOM   1734 C  CA  . ALA A 1 268 ? 141.959 166.837 165.803 1.00 46.55  ? 233  ALA A CA  1 
ATOM   1735 C  C   . ALA A 1 268 ? 142.700 166.332 164.573 1.00 46.55  ? 233  ALA A C   1 
ATOM   1736 O  O   . ALA A 1 268 ? 143.777 165.740 164.673 1.00 46.55  ? 233  ALA A O   1 
ATOM   1737 C  CB  . ALA A 1 268 ? 142.534 168.180 166.249 1.00 46.55  ? 233  ALA A CB  1 
ATOM   1738 N  N   . GLY A 1 269 ? 142.108 166.563 163.404 1.00 48.70  ? 234  GLY A N   1 
ATOM   1739 C  CA  . GLY A 1 269 ? 142.692 166.121 162.159 1.00 48.70  ? 234  GLY A CA  1 
ATOM   1740 C  C   . GLY A 1 269 ? 143.760 167.060 161.640 1.00 48.70  ? 234  GLY A C   1 
ATOM   1741 O  O   . GLY A 1 269 ? 144.055 168.110 162.210 1.00 48.70  ? 234  GLY A O   1 
ATOM   1742 N  N   . LYS A 1 270 ? 144.354 166.655 160.517 1.00 54.53  ? 235  LYS A N   1 
ATOM   1743 C  CA  . LYS A 1 270 ? 145.388 167.469 159.888 1.00 54.53  ? 235  LYS A CA  1 
ATOM   1744 C  C   . LYS A 1 270 ? 144.794 168.705 159.225 1.00 54.53  ? 235  LYS A C   1 
ATOM   1745 O  O   . LYS A 1 270 ? 145.407 169.779 159.237 1.00 54.53  ? 235  LYS A O   1 
ATOM   1746 C  CB  . LYS A 1 270 ? 146.163 166.632 158.870 1.00 54.53  ? 235  LYS A CB  1 
ATOM   1747 C  CG  . LYS A 1 270 ? 145.283 165.734 158.013 1.00 54.53  ? 235  LYS A CG  1 
ATOM   1748 C  CD  . LYS A 1 270 ? 146.055 164.558 157.433 1.00 54.53  ? 235  LYS A CD  1 
ATOM   1749 C  CE  . LYS A 1 270 ? 147.339 165.006 156.754 1.00 54.53  ? 235  LYS A CE  1 
ATOM   1750 N  NZ  . LYS A 1 270 ? 148.177 163.849 156.330 1.00 54.53  ? 235  LYS A NZ  1 
ATOM   1751 N  N   . GLN A 1 271 ? 143.604 168.576 158.646 1.00 52.09  ? 236  GLN A N   1 
ATOM   1752 C  CA  . GLN A 1 271 ? 142.999 169.652 157.874 1.00 52.09  ? 236  GLN A CA  1 
ATOM   1753 C  C   . GLN A 1 271 ? 142.311 170.653 158.800 1.00 52.09  ? 236  GLN A C   1 
ATOM   1754 O  O   . GLN A 1 271 ? 142.455 170.617 160.025 1.00 52.09  ? 236  GLN A O   1 
ATOM   1755 C  CB  . GLN A 1 271 ? 142.022 169.079 156.855 1.00 52.09  ? 236  GLN A CB  1 
ATOM   1756 C  CG  . GLN A 1 271 ? 142.662 168.159 155.849 1.00 52.09  ? 236  GLN A CG  1 
ATOM   1757 C  CD  . GLN A 1 271 ? 141.642 167.458 154.988 1.00 52.09  ? 236  GLN A CD  1 
ATOM   1758 O  OE1 . GLN A 1 271 ? 141.929 166.425 154.386 1.00 52.09  ? 236  GLN A OE1 1 
ATOM   1759 N  NE2 . GLN A 1 271 ? 140.438 168.013 154.926 1.00 52.09  ? 236  GLN A NE2 1 
ATOM   1760 N  N   . ARG A 1 272 ? 141.548 171.570 158.202 1.00 61.82  ? 237  ARG A N   1 
ATOM   1761 C  CA  . ARG A 1 272 ? 140.852 172.587 158.981 1.00 61.82  ? 237  ARG A CA  1 
ATOM   1762 C  C   . ARG A 1 272 ? 139.647 172.005 159.712 1.00 61.82  ? 237  ARG A C   1 
ATOM   1763 O  O   . ARG A 1 272 ? 139.389 172.356 160.869 1.00 61.82  ? 237  ARG A O   1 
ATOM   1764 C  CB  . ARG A 1 272 ? 140.429 173.735 158.062 1.00 61.82  ? 237  ARG A CB  1 
ATOM   1765 C  CG  . ARG A 1 272 ? 139.574 174.806 158.719 1.00 61.82  ? 237  ARG A CG  1 
ATOM   1766 C  CD  . ARG A 1 272 ? 140.424 175.801 159.502 1.00 61.82  ? 237  ARG A CD  1 
ATOM   1767 N  NE  . ARG A 1 272 ? 139.696 176.402 160.614 1.00 61.82  ? 237  ARG A NE  1 
ATOM   1768 C  CZ  . ARG A 1 272 ? 139.386 175.779 161.744 1.00 61.82  ? 237  ARG A CZ  1 
ATOM   1769 N  NH1 . ARG A 1 272 ? 139.760 174.530 161.973 1.00 61.82  ? 237  ARG A NH1 1 
ATOM   1770 N  NH2 . ARG A 1 272 ? 138.688 176.428 162.671 1.00 61.82  ? 237  ARG A NH2 1 
ATOM   1771 N  N   . GLY A 1 273 ? 138.908 171.106 159.065 1.00 54.01  ? 238  GLY A N   1 
ATOM   1772 C  CA  . GLY A 1 273 ? 137.639 170.653 159.601 1.00 54.01  ? 238  GLY A CA  1 
ATOM   1773 C  C   . GLY A 1 273 ? 137.452 169.150 159.676 1.00 54.01  ? 238  GLY A C   1 
ATOM   1774 O  O   . GLY A 1 273 ? 136.354 168.652 159.413 1.00 54.01  ? 238  GLY A O   1 
ATOM   1775 N  N   . MET A 1 274 ? 138.505 168.415 160.021 1.00 49.63  ? 239  MET A N   1 
ATOM   1776 C  CA  . MET A 1 274 ? 138.452 166.963 160.119 1.00 49.63  ? 239  MET A CA  1 
ATOM   1777 C  C   . MET A 1 274 ? 138.760 166.532 161.545 1.00 49.63  ? 239  MET A C   1 
ATOM   1778 O  O   . MET A 1 274 ? 139.587 167.148 162.222 1.00 49.63  ? 239  MET A O   1 
ATOM   1779 C  CB  . MET A 1 274 ? 139.441 166.309 159.151 1.00 49.63  ? 239  MET A CB  1 
ATOM   1780 C  CG  . MET A 1 274 ? 139.321 164.800 159.055 1.00 49.63  ? 239  MET A CG  1 
ATOM   1781 S  SD  . MET A 1 274 ? 139.607 164.193 157.388 1.00 49.63  ? 239  MET A SD  1 
ATOM   1782 C  CE  . MET A 1 274 ? 138.111 164.733 156.572 1.00 49.63  ? 239  MET A CE  1 
ATOM   1783 N  N   . ILE A 1 275 ? 138.087 165.474 162.001 1.00 44.90  ? 240  ILE A N   1 
ATOM   1784 C  CA  . ILE A 1 275 ? 138.235 164.964 163.365 1.00 44.90  ? 240  ILE A CA  1 
ATOM   1785 C  C   . ILE A 1 275 ? 138.504 163.466 163.240 1.00 44.90  ? 240  ILE A C   1 
ATOM   1786 O  O   . ILE A 1 275 ? 137.598 162.674 162.963 1.00 44.90  ? 240  ILE A O   1 
ATOM   1787 C  CB  . ILE A 1 275 ? 137.005 165.244 164.235 1.00 44.90  ? 240  ILE A CB  1 
ATOM   1788 C  CG1 . ILE A 1 275 ? 136.955 166.727 164.598 1.00 44.90  ? 240  ILE A CG1 1 
ATOM   1789 C  CG2 . ILE A 1 275 ? 137.060 164.442 165.523 1.00 44.90  ? 240  ILE A CG2 1 
ATOM   1790 C  CD1 . ILE A 1 275 ? 135.890 167.080 165.607 1.00 44.90  ? 240  ILE A CD1 1 
ATOM   1791 N  N   . ILE A 1 276 ? 139.771 163.072 163.384 1.00 44.28  ? 241  ILE A N   1 
ATOM   1792 C  CA  . ILE A 1 276 ? 140.111 161.658 163.291 1.00 44.28  ? 241  ILE A CA  1 
ATOM   1793 C  C   . ILE A 1 276 ? 139.656 160.930 164.544 1.00 44.28  ? 241  ILE A C   1 
ATOM   1794 O  O   . ILE A 1 276 ? 139.860 161.400 165.668 1.00 44.28  ? 241  ILE A O   1 
ATOM   1795 C  CB  . ILE A 1 276 ? 141.621 161.480 163.069 1.00 44.28  ? 241  ILE A CB  1 
ATOM   1796 C  CG1 . ILE A 1 276 ? 142.158 162.567 162.135 1.00 44.28  ? 241  ILE A CG1 1 
ATOM   1797 C  CG2 . ILE A 1 276 ? 141.928 160.082 162.566 1.00 44.28  ? 241  ILE A CG2 1 
ATOM   1798 C  CD1 . ILE A 1 276 ? 143.548 162.301 161.612 1.00 44.28  ? 241  ILE A CD1 1 
ATOM   1799 N  N   . GLU A 1 277 ? 139.053 159.759 164.367 1.00 46.97  ? 242  GLU A N   1 
ATOM   1800 C  CA  . GLU A 1 277 ? 138.654 158.936 165.499 1.00 46.97  ? 242  GLU A CA  1 
ATOM   1801 C  C   . GLU A 1 277 ? 139.479 157.658 165.495 1.00 46.97  ? 242  GLU A C   1 
ATOM   1802 O  O   . GLU A 1 277 ? 139.810 157.122 164.433 1.00 46.97  ? 242  GLU A O   1 
ATOM   1803 C  CB  . GLU A 1 277 ? 137.143 158.619 165.479 1.00 46.97  ? 242  GLU A CB  1 
ATOM   1804 C  CG  . GLU A 1 277 ? 136.763 157.275 164.885 1.00 46.97  ? 242  GLU A CG  1 
ATOM   1805 C  CD  . GLU A 1 277 ? 135.341 156.868 165.195 1.00 46.97  ? 242  GLU A CD  1 
ATOM   1806 O  OE1 . GLU A 1 277 ? 134.488 157.765 165.351 1.00 46.97  ? 242  GLU A OE1 1 
ATOM   1807 O  OE2 . GLU A 1 277 ? 135.078 155.650 165.275 1.00 46.97  ? 242  GLU A OE2 1 
ATOM   1808 N  N   . HIS A 1 278 ? 139.876 157.212 166.682 1.00 50.44  ? 243  HIS A N   1 
ATOM   1809 C  CA  . HIS A 1 278 ? 140.666 155.998 166.811 1.00 50.44  ? 243  HIS A CA  1 
ATOM   1810 C  C   . HIS A 1 278 ? 140.232 155.251 168.059 1.00 50.44  ? 243  HIS A C   1 
ATOM   1811 O  O   . HIS A 1 278 ? 139.799 155.855 169.044 1.00 50.44  ? 243  HIS A O   1 
ATOM   1812 C  CB  . HIS A 1 278 ? 142.164 156.298 166.886 1.00 50.44  ? 243  HIS A CB  1 
ATOM   1813 C  CG  . HIS A 1 278 ? 142.529 157.246 167.981 1.00 50.44  ? 243  HIS A CG  1 
ATOM   1814 N  ND1 . HIS A 1 278 ? 142.577 158.610 167.801 1.00 50.44  ? 243  HIS A ND1 1 
ATOM   1815 C  CD2 . HIS A 1 278 ? 142.874 157.024 169.271 1.00 50.44  ? 243  HIS A CD2 1 
ATOM   1816 C  CE1 . HIS A 1 278 ? 142.925 159.189 168.936 1.00 50.44  ? 243  HIS A CE1 1 
ATOM   1817 N  NE2 . HIS A 1 278 ? 143.113 158.248 169.843 1.00 50.44  ? 243  HIS A NE2 1 
ATOM   1818 N  N   . GLU A 1 279 ? 140.399 153.933 168.017 1.00 69.18  ? 244  GLU A N   1 
ATOM   1819 C  CA  . GLU A 1 279 ? 140.076 153.055 169.132 1.00 69.18  ? 244  GLU A CA  1 
ATOM   1820 C  C   . GLU A 1 279 ? 141.006 153.383 170.280 1.00 69.18  ? 244  GLU A C   1 
ATOM   1821 O  O   . GLU A 1 279 ? 142.184 153.608 170.060 1.00 69.18  ? 244  GLU A O   1 
ATOM   1822 C  CB  . GLU A 1 279 ? 140.274 151.608 168.703 1.00 69.18  ? 244  GLU A CB  1 
ATOM   1823 C  CG  . GLU A 1 279 ? 140.428 150.620 169.841 1.00 69.18  ? 244  GLU A CG  1 
ATOM   1824 C  CD  . GLU A 1 279 ? 140.644 149.201 169.344 1.00 69.18  ? 244  GLU A CD  1 
ATOM   1825 O  OE1 . GLU A 1 279 ? 141.166 149.039 168.220 1.00 69.18  ? 244  GLU A OE1 1 
ATOM   1826 O  OE2 . GLU A 1 279 ? 140.295 148.246 170.074 1.00 69.18  ? 244  GLU A OE2 1 
ATOM   1827 N  N   . GLY A 1 280 ? 140.485 153.411 171.503 1.00 73.83  ? 245  GLY A N   1 
ATOM   1828 C  CA  . GLY A 1 280 ? 141.297 153.750 172.657 1.00 73.83  ? 245  GLY A CA  1 
ATOM   1829 C  C   . GLY A 1 280 ? 140.787 153.051 173.899 1.00 73.83  ? 245  GLY A C   1 
ATOM   1830 O  O   . GLY A 1 280 ? 139.663 152.549 173.935 1.00 73.83  ? 245  GLY A O   1 
ATOM   1831 N  N   . ASP A 1 281 ? 141.640 153.006 174.919 1.00 75.65  ? 246  ASP A N   1 
ATOM   1832 C  CA  . ASP A 1 281 ? 141.273 152.372 176.178 1.00 75.65  ? 246  ASP A CA  1 
ATOM   1833 C  C   . ASP A 1 281 ? 140.247 153.197 176.943 1.00 75.65  ? 246  ASP A C   1 
ATOM   1834 O  O   . ASP A 1 281 ? 140.227 154.429 176.874 1.00 75.65  ? 246  ASP A O   1 
ATOM   1835 C  CB  . ASP A 1 281 ? 142.500 152.163 177.061 1.00 75.65  ? 246  ASP A CB  1 
ATOM   1836 C  CG  . ASP A 1 281 ? 142.473 150.833 177.783 1.00 75.65  ? 246  ASP A CG  1 
ATOM   1837 O  OD1 . ASP A 1 281 ? 141.497 150.076 177.597 1.00 75.65  ? 246  ASP A OD1 1 
ATOM   1838 O  OD2 . ASP A 1 281 ? 143.438 150.537 178.517 1.00 75.65  ? 246  ASP A OD2 1 
ATOM   1839 N  N   . ARG A 1 282 ? 139.399 152.496 177.689 1.00 72.23  ? 247  ARG A N   1 
ATOM   1840 C  CA  . ARG A 1 282 ? 138.472 153.127 178.616 1.00 72.23  ? 247  ARG A CA  1 
ATOM   1841 C  C   . ARG A 1 282 ? 139.239 153.664 179.820 1.00 72.23  ? 247  ARG A C   1 
ATOM   1842 O  O   . ARG A 1 282 ? 138.691 154.385 180.654 1.00 72.23  ? 247  ARG A O   1 
ATOM   1843 C  CB  . ARG A 1 282 ? 137.393 152.138 179.072 1.00 72.23  ? 247  ARG A CB  1 
ATOM   1844 C  CG  . ARG A 1 282 ? 136.184 152.041 178.150 1.00 72.23  ? 247  ARG A CG  1 
ATOM   1845 C  CD  . ARG A 1 282 ? 135.070 151.238 178.806 1.00 72.23  ? 247  ARG A CD  1 
ATOM   1846 N  NE  . ARG A 1 282 ? 133.751 151.594 178.291 1.00 72.23  ? 247  ARG A NE  1 
ATOM   1847 C  CZ  . ARG A 1 282 ? 133.160 150.991 177.268 1.00 72.23  ? 247  ARG A CZ  1 
ATOM   1848 N  NH1 . ARG A 1 282 ? 133.740 149.989 176.628 1.00 72.23  ? 247  ARG A NH1 1 
ATOM   1849 N  NH2 . ARG A 1 282 ? 131.952 151.394 176.890 1.00 72.23  ? 247  ARG A NH2 1 
ATOM   1850 N  N   . PRO A 1 380 ? 125.167 136.243 253.679 1.00 102.11 ? 370  PRO A N   1 
ATOM   1851 C  CA  . PRO A 1 380 ? 125.623 136.296 252.286 1.00 102.11 ? 370  PRO A CA  1 
ATOM   1852 C  C   . PRO A 1 380 ? 125.669 134.920 251.627 1.00 102.11 ? 370  PRO A C   1 
ATOM   1853 O  O   . PRO A 1 380 ? 126.748 134.436 251.283 1.00 102.11 ? 370  PRO A O   1 
ATOM   1854 C  CB  . PRO A 1 380 ? 127.027 136.893 252.404 1.00 102.11 ? 370  PRO A CB  1 
ATOM   1855 C  CG  . PRO A 1 380 ? 127.484 136.487 253.761 1.00 102.11 ? 370  PRO A CG  1 
ATOM   1856 C  CD  . PRO A 1 380 ? 126.257 136.533 254.627 1.00 102.11 ? 370  PRO A CD  1 
ATOM   1857 N  N   . VAL A 1 381 ? 124.499 134.301 251.459 1.00 104.33 ? 371  VAL A N   1 
ATOM   1858 C  CA  . VAL A 1 381 ? 124.438 132.992 250.818 1.00 104.33 ? 371  VAL A CA  1 
ATOM   1859 C  C   . VAL A 1 381 ? 124.712 133.126 249.323 1.00 104.33 ? 371  VAL A C   1 
ATOM   1860 O  O   . VAL A 1 381 ? 124.559 134.195 248.719 1.00 104.33 ? 371  VAL A O   1 
ATOM   1861 C  CB  . VAL A 1 381 ? 123.080 132.319 251.076 1.00 104.33 ? 371  VAL A CB  1 
ATOM   1862 C  CG1 . VAL A 1 381 ? 122.882 132.078 252.565 1.00 104.33 ? 371  VAL A CG1 1 
ATOM   1863 C  CG2 . VAL A 1 381 ? 121.950 133.168 250.514 1.00 104.33 ? 371  VAL A CG2 1 
ATOM   1864 N  N   . SER A 1 382 ? 125.139 132.017 248.722 1.00 106.29 ? 372  SER A N   1 
ATOM   1865 C  CA  . SER A 1 382 ? 125.413 131.995 247.291 1.00 106.29 ? 372  SER A CA  1 
ATOM   1866 C  C   . SER A 1 382 ? 124.116 132.142 246.506 1.00 106.29 ? 372  SER A C   1 
ATOM   1867 O  O   . SER A 1 382 ? 123.124 131.464 246.792 1.00 106.29 ? 372  SER A O   1 
ATOM   1868 C  CB  . SER A 1 382 ? 126.123 130.697 246.907 1.00 106.29 ? 372  SER A CB  1 
ATOM   1869 O  OG  . SER A 1 382 ? 125.320 129.568 247.205 1.00 106.29 ? 372  SER A OG  1 
ATOM   1870 N  N   . LYS A 1 383 ? 124.123 133.028 245.512 1.00 103.42 ? 373  LYS A N   1 
ATOM   1871 C  CA  . LYS A 1 383 ? 122.945 133.328 244.711 1.00 103.42 ? 373  LYS A CA  1 
ATOM   1872 C  C   . LYS A 1 383 ? 123.208 132.961 243.258 1.00 103.42 ? 373  LYS A C   1 
ATOM   1873 O  O   . LYS A 1 383 ? 124.272 133.274 242.711 1.00 103.42 ? 373  LYS A O   1 
ATOM   1874 C  CB  . LYS A 1 383 ? 122.546 134.803 244.838 1.00 103.42 ? 373  LYS A CB  1 
ATOM   1875 C  CG  . LYS A 1 383 ? 123.702 135.788 244.778 1.00 103.42 ? 373  LYS A CG  1 
ATOM   1876 C  CD  . LYS A 1 383 ? 123.198 137.222 244.831 1.00 103.42 ? 373  LYS A CD  1 
ATOM   1877 C  CE  . LYS A 1 383 ? 124.339 138.221 244.715 1.00 103.42 ? 373  LYS A CE  1 
ATOM   1878 N  NZ  . LYS A 1 383 ? 123.836 139.620 244.621 1.00 103.42 ? 373  LYS A NZ  1 
ATOM   1879 N  N   . ILE A 1 384 ? 122.237 132.284 242.650 1.00 100.41 ? 374  ILE A N   1 
ATOM   1880 C  CA  . ILE A 1 384 ? 122.306 131.821 241.270 1.00 100.41 ? 374  ILE A CA  1 
ATOM   1881 C  C   . ILE A 1 384 ? 121.305 132.627 240.455 1.00 100.41 ? 374  ILE A C   1 
ATOM   1882 O  O   . ILE A 1 384 ? 120.111 132.654 240.777 1.00 100.41 ? 374  ILE A O   1 
ATOM   1883 C  CB  . ILE A 1 384 ? 122.021 130.314 241.168 1.00 100.41 ? 374  ILE A CB  1 
ATOM   1884 C  CG1 . ILE A 1 384 ? 123.057 129.509 241.960 1.00 100.41 ? 374  ILE A CG1 1 
ATOM   1885 C  CG2 . ILE A 1 384 ? 121.952 129.877 239.720 1.00 100.41 ? 374  ILE A CG2 1 
ATOM   1886 C  CD1 . ILE A 1 384 ? 122.566 129.007 243.296 1.00 100.41 ? 374  ILE A CD1 1 
ATOM   1887 N  N   . PHE A 1 385 ? 121.782 133.277 239.397 1.00 94.07  ? 375  PHE A N   1 
ATOM   1888 C  CA  . PHE A 1 385 ? 120.920 134.146 238.606 1.00 94.07  ? 375  PHE A CA  1 
ATOM   1889 C  C   . PHE A 1 385 ? 121.491 134.291 237.203 1.00 94.07  ? 375  PHE A C   1 
ATOM   1890 O  O   . PHE A 1 385 ? 122.666 134.019 236.963 1.00 94.07  ? 375  PHE A O   1 
ATOM   1891 C  CB  . PHE A 1 385 ? 120.741 135.514 239.284 1.00 94.07  ? 375  PHE A CB  1 
ATOM   1892 C  CG  . PHE A 1 385 ? 122.028 136.273 239.492 1.00 94.07  ? 375  PHE A CG  1 
ATOM   1893 C  CD1 . PHE A 1 385 ? 122.754 136.114 240.662 1.00 94.07  ? 375  PHE A CD1 1 
ATOM   1894 C  CD2 . PHE A 1 385 ? 122.502 137.156 238.534 1.00 94.07  ? 375  PHE A CD2 1 
ATOM   1895 C  CE1 . PHE A 1 385 ? 123.937 136.807 240.865 1.00 94.07  ? 375  PHE A CE1 1 
ATOM   1896 C  CE2 . PHE A 1 385 ? 123.685 137.851 238.732 1.00 94.07  ? 375  PHE A CE2 1 
ATOM   1897 C  CZ  . PHE A 1 385 ? 124.401 137.677 239.899 1.00 94.07  ? 375  PHE A CZ  1 
ATOM   1898 N  N   . PHE A 1 386 ? 120.640 134.727 236.279 1.00 80.93  ? 376  PHE A N   1 
ATOM   1899 C  CA  . PHE A 1 386 ? 121.077 134.916 234.904 1.00 80.93  ? 376  PHE A CA  1 
ATOM   1900 C  C   . PHE A 1 386 ? 121.968 136.145 234.775 1.00 80.93  ? 376  PHE A C   1 
ATOM   1901 O  O   . PHE A 1 386 ? 121.793 137.145 235.474 1.00 80.93  ? 376  PHE A O   1 
ATOM   1902 C  CB  . PHE A 1 386 ? 119.878 135.044 233.967 1.00 80.93  ? 376  PHE A CB  1 
ATOM   1903 C  CG  . PHE A 1 386 ? 119.336 133.728 233.502 1.00 80.93  ? 376  PHE A CG  1 
ATOM   1904 C  CD1 . PHE A 1 386 ? 119.957 133.038 232.478 1.00 80.93  ? 376  PHE A CD1 1 
ATOM   1905 C  CD2 . PHE A 1 386 ? 118.207 133.181 234.083 1.00 80.93  ? 376  PHE A CD2 1 
ATOM   1906 C  CE1 . PHE A 1 386 ? 119.470 131.825 232.046 1.00 80.93  ? 376  PHE A CE1 1 
ATOM   1907 C  CE2 . PHE A 1 386 ? 117.713 131.967 233.650 1.00 80.93  ? 376  PHE A CE2 1 
ATOM   1908 C  CZ  . PHE A 1 386 ? 118.345 131.289 232.631 1.00 80.93  ? 376  PHE A CZ  1 
ATOM   1909 N  N   . GLU A 1 387 ? 122.935 136.056 233.860 1.00 78.32  ? 377  GLU A N   1 
ATOM   1910 C  CA  . GLU A 1 387 ? 123.861 137.163 233.640 1.00 78.32  ? 377  GLU A CA  1 
ATOM   1911 C  C   . GLU A 1 387 ? 123.145 138.383 233.074 1.00 78.32  ? 377  GLU A C   1 
ATOM   1912 O  O   . GLU A 1 387 ? 123.300 139.498 233.584 1.00 78.32  ? 377  GLU A O   1 
ATOM   1913 C  CB  . GLU A 1 387 ? 124.987 136.724 232.704 1.00 78.32  ? 377  GLU A CB  1 
ATOM   1914 C  CG  . GLU A 1 387 ? 126.045 137.788 232.473 1.00 78.32  ? 377  GLU A CG  1 
ATOM   1915 C  CD  . GLU A 1 387 ? 127.173 137.306 231.583 1.00 78.32  ? 377  GLU A CD  1 
ATOM   1916 O  OE1 . GLU A 1 387 ? 127.069 136.188 231.041 1.00 78.32  ? 377  GLU A OE1 1 
ATOM   1917 O  OE2 . GLU A 1 387 ? 128.167 138.045 231.426 1.00 78.32  ? 377  GLU A OE2 1 
ATOM   1918 N  N   . GLN A 1 388 ? 122.355 138.192 232.017 1.00 70.76  ? 378  GLN A N   1 
ATOM   1919 C  CA  . GLN A 1 388 ? 121.702 139.299 231.328 1.00 70.76  ? 378  GLN A CA  1 
ATOM   1920 C  C   . GLN A 1 388 ? 120.238 139.449 231.728 1.00 70.76  ? 378  GLN A C   1 
ATOM   1921 O  O   . GLN A 1 388 ? 119.821 140.517 232.185 1.00 70.76  ? 378  GLN A O   1 
ATOM   1922 C  CB  . GLN A 1 388 ? 121.820 139.113 229.809 1.00 70.76  ? 378  GLN A CB  1 
ATOM   1923 C  CG  . GLN A 1 388 ? 123.186 138.642 229.347 1.00 70.76  ? 378  GLN A CG  1 
ATOM   1924 C  CD  . GLN A 1 388 ? 123.457 138.984 227.896 1.00 70.76  ? 378  GLN A CD  1 
ATOM   1925 O  OE1 . GLN A 1 388 ? 122.573 139.457 227.182 1.00 70.76  ? 378  GLN A OE1 1 
ATOM   1926 N  NE2 . GLN A 1 388 ? 124.685 138.746 227.452 1.00 70.76  ? 378  GLN A NE2 1 
ATOM   1927 N  N   . GLY A 1 389 ? 119.449 138.390 231.565 1.00 68.45  ? 379  GLY A N   1 
ATOM   1928 C  CA  . GLY A 1 389 ? 118.017 138.452 231.755 1.00 68.45  ? 379  GLY A CA  1 
ATOM   1929 C  C   . GLY A 1 389 ? 117.231 138.685 230.484 1.00 68.45  ? 379  GLY A C   1 
ATOM   1930 O  O   . GLY A 1 389 ? 116.010 138.492 230.484 1.00 68.45  ? 379  GLY A O   1 
ATOM   1931 N  N   . THR A 1 390 ? 117.895 139.098 229.406 1.00 65.32  ? 380  THR A N   1 
ATOM   1932 C  CA  . THR A 1 390 ? 117.259 139.292 228.110 1.00 65.32  ? 380  THR A CA  1 
ATOM   1933 C  C   . THR A 1 390 ? 118.293 139.012 227.031 1.00 65.32  ? 380  THR A C   1 
ATOM   1934 O  O   . THR A 1 390 ? 119.397 139.562 227.075 1.00 65.32  ? 380  THR A O   1 
ATOM   1935 C  CB  . THR A 1 390 ? 116.707 140.714 227.964 1.00 65.32  ? 380  THR A CB  1 
ATOM   1936 O  OG1 . THR A 1 390 ? 115.747 140.966 228.998 1.00 65.32  ? 380  THR A OG1 1 
ATOM   1937 C  CG2 . THR A 1 390 ? 116.041 140.894 226.609 1.00 65.32  ? 380  THR A CG2 1 
ATOM   1938 N  N   . TYR A 1 391 ? 117.938 138.160 226.072 1.00 61.13  ? 381  TYR A N   1 
ATOM   1939 C  CA  . TYR A 1 391 ? 118.854 137.754 225.017 1.00 61.13  ? 381  TYR A CA  1 
ATOM   1940 C  C   . TYR A 1 391 ? 118.217 138.014 223.662 1.00 61.13  ? 381  TYR A C   1 
ATOM   1941 O  O   . TYR A 1 391 ? 116.995 137.951 223.508 1.00 61.13  ? 381  TYR A O   1 
ATOM   1942 C  CB  . TYR A 1 391 ? 119.247 136.267 225.120 1.00 61.13  ? 381  TYR A CB  1 
ATOM   1943 C  CG  . TYR A 1 391 ? 119.864 135.848 226.439 1.00 61.13  ? 381  TYR A CG  1 
ATOM   1944 C  CD1 . TYR A 1 391 ? 121.210 135.523 226.516 1.00 61.13  ? 381  TYR A CD1 1 
ATOM   1945 C  CD2 . TYR A 1 391 ? 119.096 135.725 227.591 1.00 61.13  ? 381  TYR A CD2 1 
ATOM   1946 C  CE1 . TYR A 1 391 ? 121.782 135.128 227.709 1.00 61.13  ? 381  TYR A CE1 1 
ATOM   1947 C  CE2 . TYR A 1 391 ? 119.658 135.332 228.786 1.00 61.13  ? 381  TYR A CE2 1 
ATOM   1948 C  CZ  . TYR A 1 391 ? 121.001 135.032 228.839 1.00 61.13  ? 381  TYR A CZ  1 
ATOM   1949 O  OH  . TYR A 1 391 ? 121.565 134.635 230.029 1.00 61.13  ? 381  TYR A OH  1 
ATOM   1950 N  N   . GLN A 1 392 ? 119.061 138.308 222.677 1.00 52.96  ? 382  GLN A N   1 
ATOM   1951 C  CA  . GLN A 1 392 ? 118.618 138.599 221.318 1.00 52.96  ? 382  GLN A CA  1 
ATOM   1952 C  C   . GLN A 1 392 ? 119.377 137.687 220.366 1.00 52.96  ? 382  GLN A C   1 
ATOM   1953 O  O   . GLN A 1 392 ? 120.595 137.819 220.217 1.00 52.96  ? 382  GLN A O   1 
ATOM   1954 C  CB  . GLN A 1 392 ? 118.849 140.069 220.968 1.00 52.96  ? 382  GLN A CB  1 
ATOM   1955 C  CG  . GLN A 1 392 ? 117.855 141.024 221.606 1.00 52.96  ? 382  GLN A CG  1 
ATOM   1956 C  CD  . GLN A 1 392 ? 118.201 142.478 221.355 1.00 52.96  ? 382  GLN A CD  1 
ATOM   1957 O  OE1 . GLN A 1 392 ? 118.452 142.882 220.219 1.00 52.96  ? 382  GLN A OE1 1 
ATOM   1958 N  NE2 . GLN A 1 392 ? 118.218 143.274 222.417 1.00 52.96  ? 382  GLN A NE2 1 
ATOM   1959 N  N   . CYS A 1 393 ? 118.661 136.766 219.726 1.00 42.09  ? 383  CYS A N   1 
ATOM   1960 C  CA  . CYS A 1 393 ? 119.259 135.823 218.793 1.00 42.09  ? 383  CYS A CA  1 
ATOM   1961 C  C   . CYS A 1 393 ? 118.432 135.759 217.520 1.00 42.09  ? 383  CYS A C   1 
ATOM   1962 O  O   . CYS A 1 393 ? 117.200 135.730 217.570 1.00 42.09  ? 383  CYS A O   1 
ATOM   1963 C  CB  . CYS A 1 393 ? 119.378 134.427 219.414 1.00 42.09  ? 383  CYS A CB  1 
ATOM   1964 S  SG  . CYS A 1 393 ? 117.814 133.696 219.938 1.00 42.09  ? 383  CYS A SG  1 
ATOM   1965 N  N   . LEU A 1 394 ? 119.116 135.750 216.380 1.00 37.18  ? 384  LEU A N   1 
ATOM   1966 C  CA  . LEU A 1 394 ? 118.434 135.567 215.111 1.00 37.18  ? 384  LEU A CA  1 
ATOM   1967 C  C   . LEU A 1 394 ? 117.928 134.133 214.990 1.00 37.18  ? 384  LEU A C   1 
ATOM   1968 O  O   . LEU A 1 394 ? 118.359 133.231 215.712 1.00 37.18  ? 384  LEU A O   1 
ATOM   1969 C  CB  . LEU A 1 394 ? 119.362 135.902 213.945 1.00 37.18  ? 384  LEU A CB  1 
ATOM   1970 C  CG  . LEU A 1 394 ? 119.400 137.367 213.511 1.00 37.18  ? 384  LEU A CG  1 
ATOM   1971 C  CD1 . LEU A 1 394 ? 120.240 137.532 212.257 1.00 37.18  ? 384  LEU A CD1 1 
ATOM   1972 C  CD2 . LEU A 1 394 ? 117.995 137.897 213.288 1.00 37.18  ? 384  LEU A CD2 1 
ATOM   1973 N  N   . GLU A 1 395 ? 116.984 133.933 214.067 1.00 31.16  ? 385  GLU A N   1 
ATOM   1974 C  CA  . GLU A 1 395 ? 116.386 132.613 213.901 1.00 31.16  ? 385  GLU A CA  1 
ATOM   1975 C  C   . GLU A 1 395 ? 117.396 131.606 213.365 1.00 31.16  ? 385  GLU A C   1 
ATOM   1976 O  O   . GLU A 1 395 ? 117.405 130.445 213.789 1.00 31.16  ? 385  GLU A O   1 
ATOM   1977 C  CB  . GLU A 1 395 ? 115.173 132.697 212.978 1.00 31.16  ? 385  GLU A CB  1 
ATOM   1978 C  CG  . GLU A 1 395 ? 114.276 131.472 213.027 1.00 31.16  ? 385  GLU A CG  1 
ATOM   1979 C  CD  . GLU A 1 395 ? 113.071 131.592 212.116 1.00 31.16  ? 385  GLU A CD  1 
ATOM   1980 O  OE1 . GLU A 1 395 ? 113.257 131.883 210.916 1.00 31.16  ? 385  GLU A OE1 1 
ATOM   1981 O  OE2 . GLU A 1 395 ? 111.938 131.397 212.600 1.00 31.16  ? 385  GLU A OE2 1 
ATOM   1982 N  N   . ASN A 1 396 ? 118.259 132.028 212.444 1.00 32.71  ? 386  ASN A N   1 
ATOM   1983 C  CA  . ASN A 1 396 ? 119.190 131.118 211.788 1.00 32.71  ? 386  ASN A CA  1 
ATOM   1984 C  C   . ASN A 1 396 ? 120.486 130.918 212.561 1.00 32.71  ? 386  ASN A C   1 
ATOM   1985 O  O   . ASN A 1 396 ? 121.423 130.326 212.016 1.00 32.71  ? 386  ASN A O   1 
ATOM   1986 C  CB  . ASN A 1 396 ? 119.502 131.612 210.373 1.00 32.71  ? 386  ASN A CB  1 
ATOM   1987 C  CG  . ASN A 1 396 ? 120.149 132.979 210.361 1.00 32.71  ? 386  ASN A CG  1 
ATOM   1988 O  OD1 . ASN A 1 396 ? 120.117 133.703 211.354 1.00 32.71  ? 386  ASN A OD1 1 
ATOM   1989 N  ND2 . ASN A 1 396 ? 120.740 133.342 209.230 1.00 32.71  ? 386  ASN A ND2 1 
ATOM   1990 N  N   . CYS A 1 397 ? 120.572 131.408 213.800 1.00 38.50  ? 387  CYS A N   1 
ATOM   1991 C  CA  . CYS A 1 397 ? 121.759 131.156 214.611 1.00 38.50  ? 387  CYS A CA  1 
ATOM   1992 C  C   . CYS A 1 397 ? 121.892 129.677 214.945 1.00 38.50  ? 387  CYS A C   1 
ATOM   1993 O  O   . CYS A 1 397 ? 123.002 129.132 214.958 1.00 38.50  ? 387  CYS A O   1 
ATOM   1994 C  CB  . CYS A 1 397 ? 121.712 131.989 215.891 1.00 38.50  ? 387  CYS A CB  1 
ATOM   1995 S  SG  . CYS A 1 397 ? 120.577 131.362 217.147 1.00 38.50  ? 387  CYS A SG  1 
ATOM   1996 N  N   . GLY A 1 398 ? 120.776 129.014 215.220 1.00 41.28  ? 388  GLY A N   1 
ATOM   1997 C  CA  . GLY A 1 398 ? 120.750 127.602 215.565 1.00 41.28  ? 388  GLY A CA  1 
ATOM   1998 C  C   . GLY A 1 398 ? 120.771 127.327 217.054 1.00 41.28  ? 388  GLY A C   1 
ATOM   1999 O  O   . GLY A 1 398 ? 120.049 126.451 217.534 1.00 41.28  ? 388  GLY A O   1 
ATOM   2000 N  N   . THR A 1 399 ? 121.590 128.068 217.798 1.00 44.46  ? 389  THR A N   1 
ATOM   2001 C  CA  . THR A 1 399 ? 121.673 127.937 219.246 1.00 44.46  ? 389  THR A CA  1 
ATOM   2002 C  C   . THR A 1 399 ? 121.783 129.317 219.876 1.00 44.46  ? 389  THR A C   1 
ATOM   2003 O  O   . THR A 1 399 ? 122.554 130.161 219.412 1.00 44.46  ? 389  THR A O   1 
ATOM   2004 C  CB  . THR A 1 399 ? 122.878 127.087 219.680 1.00 44.46  ? 389  THR A CB  1 
ATOM   2005 O  OG1 . THR A 1 399 ? 124.071 127.596 219.069 1.00 44.46  ? 389  THR A OG1 1 
ATOM   2006 C  CG2 . THR A 1 399 ? 122.693 125.622 219.307 1.00 44.46  ? 389  THR A CG2 1 
ATOM   2007 N  N   . VAL A 1 400 ? 121.015 129.537 220.938 1.00 47.90  ? 390  VAL A N   1 
ATOM   2008 C  CA  . VAL A 1 400 ? 121.131 130.732 221.763 1.00 47.90  ? 390  VAL A CA  1 
ATOM   2009 C  C   . VAL A 1 400 ? 121.852 130.344 223.047 1.00 47.90  ? 390  VAL A C   1 
ATOM   2010 O  O   . VAL A 1 400 ? 121.530 129.322 223.672 1.00 47.90  ? 390  VAL A O   1 
ATOM   2011 C  CB  . VAL A 1 400 ? 119.756 131.369 222.041 1.00 47.90  ? 390  VAL A CB  1 
ATOM   2012 C  CG1 . VAL A 1 400 ? 118.763 130.349 222.565 1.00 47.90  ? 390  VAL A CG1 1 
ATOM   2013 C  CG2 . VAL A 1 400 ? 119.886 132.533 223.006 1.00 47.90  ? 390  VAL A CG2 1 
ATOM   2014 N  N   . ALA A 1 401 ? 122.859 131.134 223.414 1.00 55.71  ? 391  ALA A N   1 
ATOM   2015 C  CA  . ALA A 1 401 ? 123.783 130.805 224.495 1.00 55.71  ? 391  ALA A CA  1 
ATOM   2016 C  C   . ALA A 1 401 ? 123.388 131.582 225.743 1.00 55.71  ? 391  ALA A C   1 
ATOM   2017 O  O   . ALA A 1 401 ? 123.721 132.760 225.888 1.00 55.71  ? 391  ALA A O   1 
ATOM   2018 C  CB  . ALA A 1 401 ? 125.218 131.112 224.080 1.00 55.71  ? 391  ALA A CB  1 
ATOM   2019 N  N   . LEU A 1 402 ? 122.674 130.918 226.645 1.00 64.59  ? 392  LEU A N   1 
ATOM   2020 C  CA  . LEU A 1 402 ? 122.331 131.517 227.923 1.00 64.59  ? 392  LEU A CA  1 
ATOM   2021 C  C   . LEU A 1 402 ? 123.452 131.258 228.923 1.00 64.59  ? 392  LEU A C   1 
ATOM   2022 O  O   . LEU A 1 402 ? 124.200 130.283 228.809 1.00 64.59  ? 392  LEU A O   1 
ATOM   2023 C  CB  . LEU A 1 402 ? 121.007 130.953 228.447 1.00 64.59  ? 392  LEU A CB  1 
ATOM   2024 C  CG  . LEU A 1 402 ? 119.672 131.473 227.891 1.00 64.59  ? 392  LEU A CG  1 
ATOM   2025 C  CD1 . LEU A 1 402 ? 119.461 131.121 226.423 1.00 64.59  ? 392  LEU A CD1 1 
ATOM   2026 C  CD2 . LEU A 1 402 ? 118.511 130.953 228.722 1.00 64.59  ? 392  LEU A CD2 1 
ATOM   2027 N  N   . THR A 1 403 ? 123.577 132.147 229.905 1.00 72.09  ? 393  THR A N   1 
ATOM   2028 C  CA  . THR A 1 403 ? 124.650 132.062 230.886 1.00 72.09  ? 393  THR A CA  1 
ATOM   2029 C  C   . THR A 1 403 ? 124.062 132.165 232.285 1.00 72.09  ? 393  THR A C   1 
ATOM   2030 O  O   . THR A 1 403 ? 123.128 132.937 232.514 1.00 72.09  ? 393  THR A O   1 
ATOM   2031 C  CB  . THR A 1 403 ? 125.687 133.168 230.660 1.00 72.09  ? 393  THR A CB  1 
ATOM   2032 O  OG1 . THR A 1 403 ? 126.080 133.175 229.282 1.00 72.09  ? 393  THR A OG1 1 
ATOM   2033 C  CG2 . THR A 1 403 ? 126.922 132.933 231.514 1.00 72.09  ? 393  THR A CG2 1 
ATOM   2034 N  N   . ILE A 1 404 ? 124.609 131.390 233.220 1.00 86.85  ? 394  ILE A N   1 
ATOM   2035 C  CA  . ILE A 1 404 ? 124.124 131.351 234.592 1.00 86.85  ? 394  ILE A CA  1 
ATOM   2036 C  C   . ILE A 1 404 ? 125.290 131.658 235.523 1.00 86.85  ? 394  ILE A C   1 
ATOM   2037 O  O   . ILE A 1 404 ? 126.335 130.999 235.455 1.00 86.85  ? 394  ILE A O   1 
ATOM   2038 C  CB  . ILE A 1 404 ? 123.491 129.986 234.922 1.00 86.85  ? 394  ILE A CB  1 
ATOM   2039 C  CG1 . ILE A 1 404 ? 122.092 129.894 234.312 1.00 86.85  ? 394  ILE A CG1 1 
ATOM   2040 C  CG2 . ILE A 1 404 ? 123.407 129.776 236.410 1.00 86.85  ? 394  ILE A CG2 1 
ATOM   2041 C  CD1 . ILE A 1 404 ? 121.473 128.519 234.411 1.00 86.85  ? 394  ILE A CD1 1 
ATOM   2042 N  N   . ILE A 1 405 ? 125.109 132.653 236.391 1.00 95.07  ? 395  ILE A N   1 
ATOM   2043 C  CA  . ILE A 1 405 ? 126.142 133.165 237.282 1.00 95.07  ? 395  ILE A CA  1 
ATOM   2044 C  C   . ILE A 1 405 ? 125.805 132.730 238.702 1.00 95.07  ? 395  ILE A C   1 
ATOM   2045 O  O   . ILE A 1 405 ? 124.672 132.920 239.165 1.00 95.07  ? 395  ILE A O   1 
ATOM   2046 C  CB  . ILE A 1 405 ? 126.234 134.700 237.191 1.00 95.07  ? 395  ILE A CB  1 
ATOM   2047 C  CG1 . ILE A 1 405 ? 127.078 135.136 235.994 1.00 95.07  ? 395  ILE A CG1 1 
ATOM   2048 C  CG2 . ILE A 1 405 ? 126.825 135.295 238.463 1.00 95.07  ? 395  ILE A CG2 1 
ATOM   2049 C  CD1 . ILE A 1 405 ? 128.442 134.528 235.969 1.00 95.07  ? 395  ILE A CD1 1 
ATOM   2050 N  N   . ARG A 1 406 ? 126.782 132.143 239.389 1.00 106.70 ? 396  ARG A N   1 
ATOM   2051 C  CA  . ARG A 1 406 ? 126.705 131.897 240.824 1.00 106.70 ? 396  ARG A CA  1 
ATOM   2052 C  C   . ARG A 1 406 ? 127.671 132.857 241.503 1.00 106.70 ? 396  ARG A C   1 
ATOM   2053 O  O   . ARG A 1 406 ? 128.868 132.854 241.198 1.00 106.70 ? 396  ARG A O   1 
ATOM   2054 C  CB  . ARG A 1 406 ? 127.042 130.441 241.158 1.00 106.70 ? 396  ARG A CB  1 
ATOM   2055 C  CG  . ARG A 1 406 ? 126.715 130.014 242.594 1.00 106.70 ? 396  ARG A CG  1 
ATOM   2056 C  CD  . ARG A 1 406 ? 127.885 130.196 243.563 1.00 106.70 ? 396  ARG A CD  1 
ATOM   2057 N  NE  . ARG A 1 406 ? 129.069 129.446 243.158 1.00 106.70 ? 396  ARG A NE  1 
ATOM   2058 C  CZ  . ARG A 1 406 ? 129.262 128.158 243.414 1.00 106.70 ? 396  ARG A CZ  1 
ATOM   2059 N  NH1 . ARG A 1 406 ? 128.372 127.445 244.084 1.00 106.70 ? 396  ARG A NH1 1 
ATOM   2060 N  NH2 . ARG A 1 406 ? 130.379 127.573 242.989 1.00 106.70 ? 396  ARG A NH2 1 
ATOM   2061 N  N   . ARG A 1 407 ? 127.155 133.674 242.419 1.00 104.66 ? 397  ARG A N   1 
ATOM   2062 C  CA  . ARG A 1 407 ? 127.957 134.703 243.064 1.00 104.66 ? 397  ARG A CA  1 
ATOM   2063 C  C   . ARG A 1 407 ? 127.714 134.696 244.567 1.00 104.66 ? 397  ARG A C   1 
ATOM   2064 O  O   . ARG A 1 407 ? 126.620 134.380 245.037 1.00 104.66 ? 397  ARG A O   1 
ATOM   2065 C  CB  . ARG A 1 407 ? 127.649 136.092 242.486 1.00 104.66 ? 397  ARG A CB  1 
ATOM   2066 C  CG  . ARG A 1 407 ? 128.751 137.117 242.704 1.00 104.66 ? 397  ARG A CG  1 
ATOM   2067 C  CD  . ARG A 1 407 ? 128.859 138.081 241.535 1.00 104.66 ? 397  ARG A CD  1 
ATOM   2068 N  NE  . ARG A 1 407 ? 129.631 137.519 240.433 1.00 104.66 ? 397  ARG A NE  1 
ATOM   2069 C  CZ  . ARG A 1 407 ? 129.849 138.136 239.280 1.00 104.66 ? 397  ARG A CZ  1 
ATOM   2070 N  NH1 . ARG A 1 407 ? 129.360 139.341 239.038 1.00 104.66 ? 397  ARG A NH1 1 
ATOM   2071 N  NH2 . ARG A 1 407 ? 130.577 137.530 238.347 1.00 104.66 ? 397  ARG A NH2 1 
ATOM   2072 N  N   . GLY A 1 408 ? 128.752 135.052 245.319 1.00 102.80 ? 398  GLY A N   1 
ATOM   2073 C  CA  . GLY A 1 408 ? 128.649 135.118 246.761 1.00 102.80 ? 398  GLY A CA  1 
ATOM   2074 C  C   . GLY A 1 408 ? 128.776 133.757 247.416 1.00 102.80 ? 398  GLY A C   1 
ATOM   2075 O  O   . GLY A 1 408 ? 129.003 132.729 246.774 1.00 102.80 ? 398  GLY A O   1 
ATOM   2076 N  N   . GLY A 1 409 ? 128.605 133.760 248.735 1.00 104.04 ? 399  GLY A N   1 
ATOM   2077 C  CA  . GLY A 1 409 ? 128.787 132.537 249.501 1.00 104.04 ? 399  GLY A CA  1 
ATOM   2078 C  C   . GLY A 1 409 ? 130.236 132.095 249.460 1.00 104.04 ? 399  GLY A C   1 
ATOM   2079 O  O   . GLY A 1 409 ? 131.159 132.900 249.625 1.00 104.04 ? 399  GLY A O   1 
ATOM   2080 N  N   . ASP A 1 410 ? 130.445 130.802 249.235 1.00 111.30 ? 400  ASP A N   1 
ATOM   2081 C  CA  . ASP A 1 410 ? 131.777 130.234 249.089 1.00 111.30 ? 400  ASP A CA  1 
ATOM   2082 C  C   . ASP A 1 410 ? 131.885 129.531 247.744 1.00 111.30 ? 400  ASP A C   1 
ATOM   2083 O  O   . ASP A 1 410 ? 130.942 128.865 247.303 1.00 111.30 ? 400  ASP A O   1 
ATOM   2084 C  CB  . ASP A 1 410 ? 132.097 129.258 250.229 1.00 111.30 ? 400  ASP A CB  1 
ATOM   2085 C  CG  . ASP A 1 410 ? 131.054 128.167 250.377 1.00 111.30 ? 400  ASP A CG  1 
ATOM   2086 O  OD1 . ASP A 1 410 ? 129.905 128.371 249.933 1.00 111.30 ? 400  ASP A OD1 1 
ATOM   2087 O  OD2 . ASP A 1 410 ? 131.386 127.102 250.939 1.00 111.30 ? 400  ASP A OD2 1 
ATOM   2088 N  N   . LEU A 1 411 ? 133.034 129.700 247.088 1.00 110.02 ? 401  LEU A N   1 
ATOM   2089 C  CA  . LEU A 1 411 ? 133.249 129.058 245.796 1.00 110.02 ? 401  LEU A CA  1 
ATOM   2090 C  C   . LEU A 1 411 ? 133.339 127.544 245.939 1.00 110.02 ? 401  LEU A C   1 
ATOM   2091 O  O   . LEU A 1 411 ? 132.889 126.804 245.057 1.00 110.02 ? 401  LEU A O   1 
ATOM   2092 C  CB  . LEU A 1 411 ? 134.512 129.611 245.137 1.00 110.02 ? 401  LEU A CB  1 
ATOM   2093 C  CG  . LEU A 1 411 ? 134.390 130.993 244.494 1.00 110.02 ? 401  LEU A CG  1 
ATOM   2094 C  CD1 . LEU A 1 411 ? 135.649 131.338 243.715 1.00 110.02 ? 401  LEU A CD1 1 
ATOM   2095 C  CD2 . LEU A 1 411 ? 133.163 131.063 243.599 1.00 110.02 ? 401  LEU A CD2 1 
ATOM   2096 N  N   . THR A 1 412 ? 133.910 127.065 247.045 1.00 113.16 ? 402  THR A N   1 
ATOM   2097 C  CA  . THR A 1 412 ? 134.097 125.632 247.271 1.00 113.16 ? 402  THR A CA  1 
ATOM   2098 C  C   . THR A 1 412 ? 132.802 125.025 247.817 1.00 113.16 ? 402  THR A C   1 
ATOM   2099 O  O   . THR A 1 412 ? 132.669 124.695 248.997 1.00 113.16 ? 402  THR A O   1 
ATOM   2100 C  CB  . THR A 1 412 ? 135.267 125.388 248.214 1.00 113.16 ? 402  THR A CB  1 
ATOM   2101 O  OG1 . THR A 1 412 ? 134.976 125.956 249.497 1.00 113.16 ? 402  THR A OG1 1 
ATOM   2102 C  CG2 . THR A 1 412 ? 136.536 126.023 247.662 1.00 113.16 ? 402  THR A CG2 1 
ATOM   2103 N  N   . ASN A 1 413 ? 131.829 124.883 246.919 1.00 111.42 ? 403  ASN A N   1 
ATOM   2104 C  CA  . ASN A 1 413 ? 130.552 124.275 247.264 1.00 111.42 ? 403  ASN A CA  1 
ATOM   2105 C  C   . ASN A 1 413 ? 129.958 123.629 246.021 1.00 111.42 ? 403  ASN A C   1 
ATOM   2106 O  O   . ASN A 1 413 ? 130.278 124.003 244.890 1.00 111.42 ? 403  ASN A O   1 
ATOM   2107 C  CB  . ASN A 1 413 ? 129.582 125.304 247.858 1.00 111.42 ? 403  ASN A CB  1 
ATOM   2108 C  CG  . ASN A 1 413 ? 128.723 124.722 248.962 1.00 111.42 ? 403  ASN A CG  1 
ATOM   2109 O  OD1 . ASN A 1 413 ? 128.540 123.508 249.047 1.00 111.42 ? 403  ASN A OD1 1 
ATOM   2110 N  ND2 . ASN A 1 413 ? 128.193 125.588 249.818 1.00 111.42 ? 403  ASN A ND2 1 
ATOM   2111 N  N   . THR A 1 414 ? 129.086 122.648 246.246 1.00 109.61 ? 404  THR A N   1 
ATOM   2112 C  CA  . THR A 1 414 ? 128.440 121.898 245.174 1.00 109.61 ? 404  THR A CA  1 
ATOM   2113 C  C   . THR A 1 414 ? 126.935 122.102 245.260 1.00 109.61 ? 404  THR A C   1 
ATOM   2114 O  O   . THR A 1 414 ? 126.317 121.771 246.278 1.00 109.61 ? 404  THR A O   1 
ATOM   2115 C  CB  . THR A 1 414 ? 128.781 120.409 245.264 1.00 109.61 ? 404  THR A CB  1 
ATOM   2116 O  OG1 . THR A 1 414 ? 128.526 119.940 246.593 1.00 109.61 ? 404  THR A OG1 1 
ATOM   2117 C  CG2 . THR A 1 414 ? 130.244 120.177 244.924 1.00 109.61 ? 404  THR A CG2 1 
ATOM   2118 N  N   . VAL A 1 415 ? 126.346 122.639 244.191 1.00 107.34 ? 405  VAL A N   1 
ATOM   2119 C  CA  . VAL A 1 415 ? 124.911 122.883 244.135 1.00 107.34 ? 405  VAL A CA  1 
ATOM   2120 C  C   . VAL A 1 415 ? 124.355 122.394 242.804 1.00 107.34 ? 405  VAL A C   1 
ATOM   2121 O  O   . VAL A 1 415 ? 125.047 122.368 241.781 1.00 107.34 ? 405  VAL A O   1 
ATOM   2122 C  CB  . VAL A 1 415 ? 124.559 124.375 244.353 1.00 107.34 ? 405  VAL A CB  1 
ATOM   2123 C  CG1 . VAL A 1 415 ? 124.866 124.802 245.783 1.00 107.34 ? 405  VAL A CG1 1 
ATOM   2124 C  CG2 . VAL A 1 415 ? 125.309 125.250 243.371 1.00 107.34 ? 405  VAL A CG2 1 
ATOM   2125 N  N   . PHE A 1 416 ? 123.085 121.999 242.838 1.00 102.88 ? 406  PHE A N   1 
ATOM   2126 C  CA  . PHE A 1 416 ? 122.334 121.548 241.675 1.00 102.88 ? 406  PHE A CA  1 
ATOM   2127 C  C   . PHE A 1 416 ? 121.268 122.577 241.325 1.00 102.88 ? 406  PHE A C   1 
ATOM   2128 O  O   . PHE A 1 416 ? 120.578 123.090 242.214 1.00 102.88 ? 406  PHE A O   1 
ATOM   2129 C  CB  . PHE A 1 416 ? 121.644 120.204 241.934 1.00 102.88 ? 406  PHE A CB  1 
ATOM   2130 C  CG  . PHE A 1 416 ? 122.526 119.167 242.561 1.00 102.88 ? 406  PHE A CG  1 
ATOM   2131 C  CD1 . PHE A 1 416 ? 123.573 118.607 241.853 1.00 102.88 ? 406  PHE A CD1 1 
ATOM   2132 C  CD2 . PHE A 1 416 ? 122.292 118.733 243.856 1.00 102.88 ? 406  PHE A CD2 1 
ATOM   2133 C  CE1 . PHE A 1 416 ? 124.382 117.644 242.425 1.00 102.88 ? 406  PHE A CE1 1 
ATOM   2134 C  CE2 . PHE A 1 416 ? 123.096 117.771 244.435 1.00 102.88 ? 406  PHE A CE2 1 
ATOM   2135 C  CZ  . PHE A 1 416 ? 124.142 117.225 243.716 1.00 102.88 ? 406  PHE A CZ  1 
ATOM   2136 N  N   . VAL A 1 417 ? 121.127 122.868 240.032 1.00 95.01  ? 407  VAL A N   1 
ATOM   2137 C  CA  . VAL A 1 417 ? 120.062 123.741 239.548 1.00 95.01  ? 407  VAL A CA  1 
ATOM   2138 C  C   . VAL A 1 417 ? 119.510 123.173 238.242 1.00 95.01  ? 407  VAL A C   1 
ATOM   2139 O  O   . VAL A 1 417 ? 120.266 122.723 237.374 1.00 95.01  ? 407  VAL A O   1 
ATOM   2140 C  CB  . VAL A 1 417 ? 120.554 125.201 239.396 1.00 95.01  ? 407  VAL A CB  1 
ATOM   2141 C  CG1 . VAL A 1 417 ? 121.758 125.292 238.478 1.00 95.01  ? 407  VAL A CG1 1 
ATOM   2142 C  CG2 . VAL A 1 417 ? 119.432 126.107 238.907 1.00 95.01  ? 407  VAL A CG2 1 
ATOM   2143 N  N   . ASP A 1 418 ? 118.183 123.178 238.113 1.00 88.77  ? 408  ASP A N   1 
ATOM   2144 C  CA  . ASP A 1 418 ? 117.483 122.593 236.978 1.00 88.77  ? 408  ASP A CA  1 
ATOM   2145 C  C   . ASP A 1 418 ? 116.836 123.696 236.151 1.00 88.77  ? 408  ASP A C   1 
ATOM   2146 O  O   . ASP A 1 418 ? 116.054 124.492 236.679 1.00 88.77  ? 408  ASP A O   1 
ATOM   2147 C  CB  . ASP A 1 418 ? 116.428 121.601 237.474 1.00 88.77  ? 408  ASP A CB  1 
ATOM   2148 C  CG  . ASP A 1 418 ? 116.047 120.580 236.431 1.00 88.77  ? 408  ASP A CG  1 
ATOM   2149 O  OD1 . ASP A 1 418 ? 115.700 120.990 235.306 1.00 88.77  ? 408  ASP A OD1 1 
ATOM   2150 O  OD2 . ASP A 1 418 ? 116.089 119.369 236.734 1.00 88.77  ? 408  ASP A OD2 1 
ATOM   2151 N  N   . PHE A 1 419 ? 117.149 123.735 234.858 1.00 80.68  ? 409  PHE A N   1 
ATOM   2152 C  CA  . PHE A 1 419 ? 116.600 124.735 233.951 1.00 80.68  ? 409  PHE A CA  1 
ATOM   2153 C  C   . PHE A 1 419 ? 115.680 124.063 232.941 1.00 80.68  ? 409  PHE A C   1 
ATOM   2154 O  O   . PHE A 1 419 ? 116.068 123.087 232.287 1.00 80.68  ? 409  PHE A O   1 
ATOM   2155 C  CB  . PHE A 1 419 ? 117.686 125.526 233.203 1.00 80.68  ? 409  PHE A CB  1 
ATOM   2156 C  CG  . PHE A 1 419 ? 118.711 124.684 232.473 1.00 80.68  ? 409  PHE A CG  1 
ATOM   2157 C  CD1 . PHE A 1 419 ? 119.640 123.907 233.149 1.00 80.68  ? 409  PHE A CD1 1 
ATOM   2158 C  CD2 . PHE A 1 419 ? 118.730 124.673 231.088 1.00 80.68  ? 409  PHE A CD2 1 
ATOM   2159 C  CE1 . PHE A 1 419 ? 120.568 123.149 232.458 1.00 80.68  ? 409  PHE A CE1 1 
ATOM   2160 C  CE2 . PHE A 1 419 ? 119.657 123.917 230.393 1.00 80.68  ? 409  PHE A CE2 1 
ATOM   2161 C  CZ  . PHE A 1 419 ? 120.575 123.153 231.080 1.00 80.68  ? 409  PHE A CZ  1 
ATOM   2162 N  N   . ARG A 1 420 ? 114.469 124.597 232.804 1.00 74.19  ? 410  ARG A N   1 
ATOM   2163 C  CA  . ARG A 1 420 ? 113.514 124.097 231.825 1.00 74.19  ? 410  ARG A CA  1 
ATOM   2164 C  C   . ARG A 1 420 ? 112.891 125.258 231.066 1.00 74.19  ? 410  ARG A C   1 
ATOM   2165 O  O   . ARG A 1 420 ? 112.625 126.318 231.639 1.00 74.19  ? 410  ARG A O   1 
ATOM   2166 C  CB  . ARG A 1 420 ? 112.421 123.247 232.487 1.00 74.19  ? 410  ARG A CB  1 
ATOM   2167 C  CG  . ARG A 1 420 ? 111.697 123.923 233.636 1.00 74.19  ? 410  ARG A CG  1 
ATOM   2168 C  CD  . ARG A 1 420 ? 110.813 122.927 234.373 1.00 74.19  ? 410  ARG A CD  1 
ATOM   2169 N  NE  . ARG A 1 420 ? 110.077 123.534 235.476 1.00 74.19  ? 410  ARG A NE  1 
ATOM   2170 C  CZ  . ARG A 1 420 ? 109.020 124.323 235.336 1.00 74.19  ? 410  ARG A CZ  1 
ATOM   2171 N  NH1 . ARG A 1 420 ? 108.525 124.614 234.144 1.00 74.19  ? 410  ARG A NH1 1 
ATOM   2172 N  NH2 . ARG A 1 420 ? 108.441 124.829 236.421 1.00 74.19  ? 410  ARG A NH2 1 
ATOM   2173 N  N   . THR A 1 421 ? 112.666 125.054 229.772 1.00 61.40  ? 411  THR A N   1 
ATOM   2174 C  CA  . THR A 1 421 ? 112.070 126.087 228.939 1.00 61.40  ? 411  THR A CA  1 
ATOM   2175 C  C   . THR A 1 421 ? 110.550 126.025 229.020 1.00 61.40  ? 411  THR A C   1 
ATOM   2176 O  O   . THR A 1 421 ? 109.959 124.944 229.079 1.00 61.40  ? 411  THR A O   1 
ATOM   2177 C  CB  . THR A 1 421 ? 112.523 125.938 227.489 1.00 61.40  ? 411  THR A CB  1 
ATOM   2178 O  OG1 . THR A 1 421 ? 112.085 124.674 226.979 1.00 61.40  ? 411  THR A OG1 1 
ATOM   2179 C  CG2 . THR A 1 421 ? 114.036 126.016 227.398 1.00 61.40  ? 411  THR A CG2 1 
ATOM   2180 N  N   . GLU A 1 422 ? 109.923 127.197 229.027 1.00 71.52  ? 412  GLU A N   1 
ATOM   2181 C  CA  . GLU A 1 422 ? 108.481 127.331 229.157 1.00 71.52  ? 412  GLU A CA  1 
ATOM   2182 C  C   . GLU A 1 422 ? 107.921 128.121 227.982 1.00 71.52  ? 412  GLU A C   1 
ATOM   2183 O  O   . GLU A 1 422 ? 108.543 129.082 227.503 1.00 71.52  ? 412  GLU A O   1 
ATOM   2184 C  CB  . GLU A 1 422 ? 108.107 128.010 230.481 1.00 71.52  ? 412  GLU A CB  1 
ATOM   2185 C  CG  . GLU A 1 422 ? 106.613 128.018 230.798 1.00 71.52  ? 412  GLU A CG  1 
ATOM   2186 C  CD  . GLU A 1 422 ? 106.142 126.758 231.508 1.00 71.52  ? 412  GLU A CD  1 
ATOM   2187 O  OE1 . GLU A 1 422 ? 106.758 125.688 231.322 1.00 71.52  ? 412  GLU A OE1 1 
ATOM   2188 O  OE2 . GLU A 1 422 ? 105.147 126.841 232.258 1.00 71.52  ? 412  GLU A OE2 1 
ATOM   2189 N  N   . ASP A 1 423 ? 106.739 127.698 227.536 1.00 74.20  ? 413  ASP A N   1 
ATOM   2190 C  CA  . ASP A 1 423 ? 106.064 128.300 226.395 1.00 74.20  ? 413  ASP A CA  1 
ATOM   2191 C  C   . ASP A 1 423 ? 105.735 129.764 226.650 1.00 74.20  ? 413  ASP A C   1 
ATOM   2192 O  O   . ASP A 1 423 ? 105.192 130.123 227.698 1.00 74.20  ? 413  ASP A O   1 
ATOM   2193 C  CB  . ASP A 1 423 ? 104.785 127.517 226.093 1.00 74.20  ? 413  ASP A CB  1 
ATOM   2194 C  CG  . ASP A 1 423 ? 104.050 128.035 224.875 1.00 74.20  ? 413  ASP A CG  1 
ATOM   2195 O  OD1 . ASP A 1 423 ? 102.812 127.880 224.818 1.00 74.20  ? 413  ASP A OD1 1 
ATOM   2196 O  OD2 . ASP A 1 423 ? 104.702 128.594 223.974 1.00 74.20  ? 413  ASP A OD2 1 
ATOM   2197 N  N   . GLY A 1 424 ? 106.069 130.608 225.679 1.00 65.17  ? 414  GLY A N   1 
ATOM   2198 C  CA  . GLY A 1 424 ? 105.656 131.996 225.683 1.00 65.17  ? 414  GLY A CA  1 
ATOM   2199 C  C   . GLY A 1 424 ? 104.885 132.313 224.420 1.00 65.17  ? 414  GLY A C   1 
ATOM   2200 O  O   . GLY A 1 424 ? 103.857 131.688 224.143 1.00 65.17  ? 414  GLY A O   1 
ATOM   2201 N  N   . THR A 1 425 ? 105.365 133.285 223.644 1.00 60.47  ? 415  THR A N   1 
ATOM   2202 C  CA  . THR A 1 425 ? 104.791 133.510 222.322 1.00 60.47  ? 415  THR A CA  1 
ATOM   2203 C  C   . THR A 1 425 ? 105.209 132.411 221.352 1.00 60.47  ? 415  THR A C   1 
ATOM   2204 O  O   . THR A 1 425 ? 104.377 131.892 220.598 1.00 60.47  ? 415  THR A O   1 
ATOM   2205 C  CB  . THR A 1 425 ? 105.202 134.884 221.795 1.00 60.47  ? 415  THR A CB  1 
ATOM   2206 O  OG1 . THR A 1 425 ? 104.830 135.890 222.744 1.00 60.47  ? 415  THR A OG1 1 
ATOM   2207 C  CG2 . THR A 1 425 ? 104.511 135.173 220.473 1.00 60.47  ? 415  THR A CG2 1 
ATOM   2208 N  N   . ALA A 1 426 ? 106.487 132.040 221.361 1.00 57.53  ? 416  ALA A N   1 
ATOM   2209 C  CA  . ALA A 1 426 ? 106.972 130.955 220.520 1.00 57.53  ? 416  ALA A CA  1 
ATOM   2210 C  C   . ALA A 1 426 ? 106.586 129.611 221.121 1.00 57.53  ? 416  ALA A C   1 
ATOM   2211 O  O   . ALA A 1 426 ? 106.778 129.372 222.315 1.00 57.53  ? 416  ALA A O   1 
ATOM   2212 C  CB  . ALA A 1 426 ? 108.489 131.037 220.359 1.00 57.53  ? 416  ALA A CB  1 
ATOM   2213 N  N   . ASN A 1 427 ? 106.062 128.725 220.279 1.00 59.87  ? 417  ASN A N   1 
ATOM   2214 C  CA  . ASN A 1 427 ? 105.514 127.455 220.734 1.00 59.87  ? 417  ASN A CA  1 
ATOM   2215 C  C   . ASN A 1 427 ? 106.609 126.403 220.863 1.00 59.87  ? 417  ASN A C   1 
ATOM   2216 O  O   . ASN A 1 427 ? 107.527 126.339 220.040 1.00 59.87  ? 417  ASN A O   1 
ATOM   2217 C  CB  . ASN A 1 427 ? 104.431 126.963 219.774 1.00 59.87  ? 417  ASN A CB  1 
ATOM   2218 C  CG  . ASN A 1 427 ? 103.195 127.839 219.795 1.00 59.87  ? 417  ASN A CG  1 
ATOM   2219 O  OD1 . ASN A 1 427 ? 102.592 128.057 220.845 1.00 59.87  ? 417  ASN A OD1 1 
ATOM   2220 N  ND2 . ASN A 1 427 ? 102.811 128.347 218.630 1.00 59.87  ? 417  ASN A ND2 1 
ATOM   2221 N  N   . ALA A 1 428 ? 106.503 125.584 221.906 1.00 56.48  ? 418  ALA A N   1 
ATOM   2222 C  CA  . ALA A 1 428 ? 107.481 124.532 222.148 1.00 56.48  ? 418  ALA A CA  1 
ATOM   2223 C  C   . ALA A 1 428 ? 107.368 123.438 221.094 1.00 56.48  ? 418  ALA A C   1 
ATOM   2224 O  O   . ALA A 1 428 ? 106.269 122.975 220.777 1.00 56.48  ? 418  ALA A O   1 
ATOM   2225 C  CB  . ALA A 1 428 ? 107.289 123.944 223.544 1.00 56.48  ? 418  ALA A CB  1 
ATOM   2226 N  N   . GLY A 1 429 ? 108.512 123.023 220.553 1.00 46.76  ? 419  GLY A N   1 
ATOM   2227 C  CA  . GLY A 1 429 ? 108.566 121.976 219.563 1.00 46.76  ? 419  GLY A CA  1 
ATOM   2228 C  C   . GLY A 1 429 ? 108.503 122.449 218.128 1.00 46.76  ? 419  GLY A C   1 
ATOM   2229 O  O   . GLY A 1 429 ? 108.872 121.691 217.224 1.00 46.76  ? 419  GLY A O   1 
ATOM   2230 N  N   . SER A 1 430 ? 108.052 123.679 217.889 1.00 48.14  ? 420  SER A N   1 
ATOM   2231 C  CA  . SER A 1 430 ? 107.933 124.215 216.541 1.00 48.14  ? 420  SER A CA  1 
ATOM   2232 C  C   . SER A 1 430 ? 108.908 125.340 216.240 1.00 48.14  ? 420  SER A C   1 
ATOM   2233 O  O   . SER A 1 430 ? 109.353 125.461 215.097 1.00 48.14  ? 420  SER A O   1 
ATOM   2234 C  CB  . SER A 1 430 ? 106.506 124.718 216.291 1.00 48.14  ? 420  SER A CB  1 
ATOM   2235 O  OG  . SER A 1 430 ? 106.243 125.889 217.042 1.00 48.14  ? 420  SER A OG  1 
ATOM   2236 N  N   . ASP A 1 431 ? 109.246 126.166 217.226 1.00 43.70  ? 421  ASP A N   1 
ATOM   2237 C  CA  . ASP A 1 431 ? 110.176 127.271 217.029 1.00 43.70  ? 421  ASP A CA  1 
ATOM   2238 C  C   . ASP A 1 431 ? 111.440 127.144 217.862 1.00 43.70  ? 421  ASP A C   1 
ATOM   2239 O  O   . ASP A 1 431 ? 112.522 127.490 217.386 1.00 43.70  ? 421  ASP A O   1 
ATOM   2240 C  CB  . ASP A 1 431 ? 109.492 128.602 217.351 1.00 43.70  ? 421  ASP A CB  1 
ATOM   2241 C  CG  . ASP A 1 431 ? 109.943 129.717 216.437 1.00 43.70  ? 421  ASP A CG  1 
ATOM   2242 O  OD1 . ASP A 1 431 ? 111.159 129.825 216.177 1.00 43.70  ? 421  ASP A OD1 1 
ATOM   2243 O  OD2 . ASP A 1 431 ? 109.078 130.485 215.974 1.00 43.70  ? 421  ASP A OD2 1 
ATOM   2244 N  N   . TYR A 1 432 ? 111.330 126.668 219.098 1.00 50.35  ? 422  TYR A N   1 
ATOM   2245 C  CA  . TYR A 1 432 ? 112.483 126.376 219.934 1.00 50.35  ? 422  TYR A CA  1 
ATOM   2246 C  C   . TYR A 1 432 ? 112.387 124.941 220.429 1.00 50.35  ? 422  TYR A C   1 
ATOM   2247 O  O   . TYR A 1 432 ? 111.311 124.483 220.823 1.00 50.35  ? 422  TYR A O   1 
ATOM   2248 C  CB  . TYR A 1 432 ? 112.583 127.349 221.117 1.00 50.35  ? 422  TYR A CB  1 
ATOM   2249 C  CG  . TYR A 1 432 ? 111.531 127.155 222.185 1.00 50.35  ? 422  TYR A CG  1 
ATOM   2250 C  CD1 . TYR A 1 432 ? 110.244 127.641 222.013 1.00 50.35  ? 422  TYR A CD1 1 
ATOM   2251 C  CD2 . TYR A 1 432 ? 111.827 126.493 223.367 1.00 50.35  ? 422  TYR A CD2 1 
ATOM   2252 C  CE1 . TYR A 1 432 ? 109.283 127.471 222.985 1.00 50.35  ? 422  TYR A CE1 1 
ATOM   2253 C  CE2 . TYR A 1 432 ? 110.870 126.315 224.342 1.00 50.35  ? 422  TYR A CE2 1 
ATOM   2254 C  CZ  . TYR A 1 432 ? 109.600 126.807 224.146 1.00 50.35  ? 422  TYR A CZ  1 
ATOM   2255 O  OH  . TYR A 1 432 ? 108.644 126.633 225.118 1.00 50.35  ? 422  TYR A OH  1 
ATOM   2256 N  N   . GLU A 1 433 ? 113.509 124.229 220.386 1.00 53.98  ? 423  GLU A N   1 
ATOM   2257 C  CA  . GLU A 1 433 ? 113.534 122.852 220.856 1.00 53.98  ? 423  GLU A CA  1 
ATOM   2258 C  C   . GLU A 1 433 ? 113.345 122.814 222.366 1.00 53.98  ? 423  GLU A C   1 
ATOM   2259 O  O   . GLU A 1 433 ? 113.977 123.579 223.100 1.00 53.98  ? 423  GLU A O   1 
ATOM   2260 C  CB  . GLU A 1 433 ? 114.849 122.181 220.465 1.00 53.98  ? 423  GLU A CB  1 
ATOM   2261 C  CG  . GLU A 1 433 ? 114.987 121.915 218.974 1.00 53.98  ? 423  GLU A CG  1 
ATOM   2262 C  CD  . GLU A 1 433 ? 116.287 121.218 218.620 1.00 53.98  ? 423  GLU A CD  1 
ATOM   2263 O  OE1 . GLU A 1 433 ? 117.143 121.063 219.515 1.00 53.98  ? 423  GLU A OE1 1 
ATOM   2264 O  OE2 . GLU A 1 433 ? 116.453 120.829 217.445 1.00 53.98  ? 423  GLU A OE2 1 
ATOM   2265 N  N   . PHE A 1 434 ? 112.475 121.921 222.829 1.00 57.13  ? 424  PHE A N   1 
ATOM   2266 C  CA  . PHE A 1 434 ? 112.155 121.816 224.250 1.00 57.13  ? 424  PHE A CA  1 
ATOM   2267 C  C   . PHE A 1 434 ? 113.358 121.232 224.976 1.00 57.13  ? 424  PHE A C   1 
ATOM   2268 O  O   . PHE A 1 434 ? 113.561 120.017 224.995 1.00 57.13  ? 424  PHE A O   1 
ATOM   2269 C  CB  . PHE A 1 434 ? 110.917 120.950 224.450 1.00 57.13  ? 424  PHE A CB  1 
ATOM   2270 C  CG  . PHE A 1 434 ? 110.474 120.844 225.880 1.00 57.13  ? 424  PHE A CG  1 
ATOM   2271 C  CD1 . PHE A 1 434 ? 109.726 121.853 226.461 1.00 57.13  ? 424  PHE A CD1 1 
ATOM   2272 C  CD2 . PHE A 1 434 ? 110.806 119.737 226.643 1.00 57.13  ? 424  PHE A CD2 1 
ATOM   2273 C  CE1 . PHE A 1 434 ? 109.314 121.758 227.777 1.00 57.13  ? 424  PHE A CE1 1 
ATOM   2274 C  CE2 . PHE A 1 434 ? 110.400 119.638 227.959 1.00 57.13  ? 424  PHE A CE2 1 
ATOM   2275 C  CZ  . PHE A 1 434 ? 109.652 120.649 228.527 1.00 57.13  ? 424  PHE A CZ  1 
ATOM   2276 N  N   . THR A 1 435 ? 114.159 122.098 225.587 1.00 62.93  ? 425  THR A N   1 
ATOM   2277 C  CA  . THR A 1 435 ? 115.401 121.699 226.235 1.00 62.93  ? 425  THR A CA  1 
ATOM   2278 C  C   . THR A 1 435 ? 115.232 121.787 227.744 1.00 62.93  ? 425  THR A C   1 
ATOM   2279 O  O   . THR A 1 435 ? 115.066 122.882 228.293 1.00 62.93  ? 425  THR A O   1 
ATOM   2280 C  CB  . THR A 1 435 ? 116.566 122.573 225.773 1.00 62.93  ? 425  THR A CB  1 
ATOM   2281 O  OG1 . THR A 1 435 ? 116.605 122.598 224.341 1.00 62.93  ? 425  THR A OG1 1 
ATOM   2282 C  CG2 . THR A 1 435 ? 117.881 122.023 226.298 1.00 62.93  ? 425  THR A CG2 1 
ATOM   2283 N  N   . GLU A 1 436 ? 115.278 120.636 228.407 1.00 74.75  ? 426  GLU A N   1 
ATOM   2284 C  CA  . GLU A 1 436 ? 115.211 120.539 229.857 1.00 74.75  ? 426  GLU A CA  1 
ATOM   2285 C  C   . GLU A 1 436 ? 116.497 119.900 230.356 1.00 74.75  ? 426  GLU A C   1 
ATOM   2286 O  O   . GLU A 1 436 ? 116.837 118.786 229.945 1.00 74.75  ? 426  GLU A O   1 
ATOM   2287 C  CB  . GLU A 1 436 ? 113.984 119.725 230.286 1.00 74.75  ? 426  GLU A CB  1 
ATOM   2288 C  CG  . GLU A 1 436 ? 113.671 119.753 231.773 1.00 74.75  ? 426  GLU A CG  1 
ATOM   2289 C  CD  . GLU A 1 436 ? 114.441 118.698 232.547 1.00 74.75  ? 426  GLU A CD  1 
ATOM   2290 O  OE1 . GLU A 1 436 ? 114.165 117.495 232.355 1.00 74.75  ? 426  GLU A OE1 1 
ATOM   2291 O  OE2 . GLU A 1 436 ? 115.334 119.068 233.333 1.00 74.75  ? 426  GLU A OE2 1 
ATOM   2292 N  N   . GLY A 1 437 ? 117.210 120.597 231.241 1.00 79.63  ? 427  GLY A N   1 
ATOM   2293 C  CA  . GLY A 1 437 ? 118.504 120.129 231.685 1.00 79.63  ? 427  GLY A CA  1 
ATOM   2294 C  C   . GLY A 1 437 ? 118.713 120.388 233.162 1.00 79.63  ? 427  GLY A C   1 
ATOM   2295 O  O   . GLY A 1 437 ? 118.034 121.209 233.779 1.00 79.63  ? 427  GLY A O   1 
ATOM   2296 N  N   . THR A 1 438 ? 119.669 119.653 233.723 1.00 87.01  ? 428  THR A N   1 
ATOM   2297 C  CA  . THR A 1 438 ? 120.104 119.826 235.102 1.00 87.01  ? 428  THR A CA  1 
ATOM   2298 C  C   . THR A 1 438 ? 121.611 120.035 235.099 1.00 87.01  ? 428  THR A C   1 
ATOM   2299 O  O   . THR A 1 438 ? 122.338 119.290 234.435 1.00 87.01  ? 428  THR A O   1 
ATOM   2300 C  CB  . THR A 1 438 ? 119.733 118.607 235.954 1.00 87.01  ? 428  THR A CB  1 
ATOM   2301 O  OG1 . THR A 1 438 ? 118.319 118.384 235.883 1.00 87.01  ? 428  THR A OG1 1 
ATOM   2302 C  CG2 . THR A 1 438 ? 120.134 118.820 237.406 1.00 87.01  ? 428  THR A CG2 1 
ATOM   2303 N  N   . VAL A 1 439 ? 122.082 121.043 235.831 1.00 92.49  ? 429  VAL A N   1 
ATOM   2304 C  CA  . VAL A 1 439 ? 123.506 121.341 235.875 1.00 92.49  ? 429  VAL A CA  1 
ATOM   2305 C  C   . VAL A 1 439 ? 123.967 121.449 237.320 1.00 92.49  ? 429  VAL A C   1 
ATOM   2306 O  O   . VAL A 1 439 ? 123.186 121.741 238.235 1.00 92.49  ? 429  VAL A O   1 
ATOM   2307 C  CB  . VAL A 1 439 ? 123.861 122.623 235.089 1.00 92.49  ? 429  VAL A CB  1 
ATOM   2308 C  CG1 . VAL A 1 439 ? 123.851 122.346 233.598 1.00 92.49  ? 429  VAL A CG1 1 
ATOM   2309 C  CG2 . VAL A 1 439 ? 122.885 123.729 235.416 1.00 92.49  ? 429  VAL A CG2 1 
ATOM   2310 N  N   . VAL A 1 440 ? 125.258 121.188 237.516 1.00 103.04 ? 430  VAL A N   1 
ATOM   2311 C  CA  . VAL A 1 440 ? 125.896 121.164 238.825 1.00 103.04 ? 430  VAL A CA  1 
ATOM   2312 C  C   . VAL A 1 440 ? 127.049 122.156 238.802 1.00 103.04 ? 430  VAL A C   1 
ATOM   2313 O  O   . VAL A 1 440 ? 127.846 122.165 237.857 1.00 103.04 ? 430  VAL A O   1 
ATOM   2314 C  CB  . VAL A 1 440 ? 126.411 119.757 239.183 1.00 103.04 ? 430  VAL A CB  1 
ATOM   2315 C  CG1 . VAL A 1 440 ? 126.793 119.687 240.655 1.00 103.04 ? 430  VAL A CG1 1 
ATOM   2316 C  CG2 . VAL A 1 440 ? 125.385 118.690 238.824 1.00 103.04 ? 430  VAL A CG2 1 
ATOM   2317 N  N   . PHE A 1 441 ? 127.138 122.986 239.836 1.00 108.31 ? 431  PHE A N   1 
ATOM   2318 C  CA  . PHE A 1 441 ? 128.261 123.906 239.985 1.00 108.31 ? 431  PHE A CA  1 
ATOM   2319 C  C   . PHE A 1 441 ? 129.402 123.186 240.692 1.00 108.31 ? 431  PHE A C   1 
ATOM   2320 O  O   . PHE A 1 441 ? 129.284 122.817 241.865 1.00 108.31 ? 431  PHE A O   1 
ATOM   2321 C  CB  . PHE A 1 441 ? 127.850 125.161 240.749 1.00 108.31 ? 431  PHE A CB  1 
ATOM   2322 C  CG  . PHE A 1 441 ? 127.109 126.163 239.916 1.00 108.31 ? 431  PHE A CG  1 
ATOM   2323 C  CD1 . PHE A 1 441 ? 127.798 127.026 239.080 1.00 108.31 ? 431  PHE A CD1 1 
ATOM   2324 C  CD2 . PHE A 1 441 ? 125.728 126.245 239.965 1.00 108.31 ? 431  PHE A CD2 1 
ATOM   2325 C  CE1 . PHE A 1 441 ? 127.126 127.954 238.313 1.00 108.31 ? 431  PHE A CE1 1 
ATOM   2326 C  CE2 . PHE A 1 441 ? 125.050 127.171 239.198 1.00 108.31 ? 431  PHE A CE2 1 
ATOM   2327 C  CZ  . PHE A 1 441 ? 125.752 128.025 238.371 1.00 108.31 ? 431  PHE A CZ  1 
ATOM   2328 N  N   . LYS A 1 442 ? 130.502 122.981 239.974 1.00 110.39 ? 432  LYS A N   1 
ATOM   2329 C  CA  . LYS A 1 442 ? 131.707 122.460 240.589 1.00 110.39 ? 432  LYS A CA  1 
ATOM   2330 C  C   . LYS A 1 442 ? 132.304 123.509 241.526 1.00 110.39 ? 432  LYS A C   1 
ATOM   2331 O  O   . LYS A 1 442 ? 132.102 124.710 241.329 1.00 110.39 ? 432  LYS A O   1 
ATOM   2332 C  CB  . LYS A 1 442 ? 132.726 122.069 239.522 1.00 110.39 ? 432  LYS A CB  1 
ATOM   2333 C  CG  . LYS A 1 442 ? 132.616 120.625 239.062 1.00 110.39 ? 432  LYS A CG  1 
ATOM   2334 C  CD  . LYS A 1 442 ? 133.858 120.195 238.300 1.00 110.39 ? 432  LYS A CD  1 
ATOM   2335 C  CE  . LYS A 1 442 ? 133.802 118.720 237.942 1.00 110.39 ? 432  LYS A CE  1 
ATOM   2336 N  NZ  . LYS A 1 442 ? 135.031 118.280 237.226 1.00 110.39 ? 432  LYS A NZ  1 
ATOM   2337 N  N   . PRO A 1 443 ? 133.012 123.080 242.573 1.00 111.75 ? 433  PRO A N   1 
ATOM   2338 C  CA  . PRO A 1 443 ? 133.657 124.047 243.469 1.00 111.75 ? 433  PRO A CA  1 
ATOM   2339 C  C   . PRO A 1 443 ? 134.682 124.900 242.735 1.00 111.75 ? 433  PRO A C   1 
ATOM   2340 O  O   . PRO A 1 443 ? 135.447 124.410 241.901 1.00 111.75 ? 433  PRO A O   1 
ATOM   2341 C  CB  . PRO A 1 443 ? 134.318 123.160 244.530 1.00 111.75 ? 433  PRO A CB  1 
ATOM   2342 C  CG  . PRO A 1 443 ? 133.525 121.898 244.507 1.00 111.75 ? 433  PRO A CG  1 
ATOM   2343 C  CD  . PRO A 1 443 ? 133.150 121.699 243.069 1.00 111.75 ? 433  PRO A CD  1 
ATOM   2344 N  N   . GLY A 1 444 ? 134.688 126.193 243.054 1.00 109.83 ? 434  GLY A N   1 
ATOM   2345 C  CA  . GLY A 1 444 ? 135.592 127.134 242.431 1.00 109.83 ? 434  GLY A CA  1 
ATOM   2346 C  C   . GLY A 1 444 ? 135.141 127.685 241.095 1.00 109.83 ? 434  GLY A C   1 
ATOM   2347 O  O   . GLY A 1 444 ? 135.896 128.442 240.473 1.00 109.83 ? 434  GLY A O   1 
ATOM   2348 N  N   . ASP A 1 445 ? 133.944 127.334 240.632 1.00 107.96 ? 435  ASP A N   1 
ATOM   2349 C  CA  . ASP A 1 445 ? 133.431 127.787 239.346 1.00 107.96 ? 435  ASP A CA  1 
ATOM   2350 C  C   . ASP A 1 445 ? 132.260 128.735 239.568 1.00 107.96 ? 435  ASP A C   1 
ATOM   2351 O  O   . ASP A 1 445 ? 131.346 128.430 240.341 1.00 107.96 ? 435  ASP A O   1 
ATOM   2352 C  CB  . ASP A 1 445 ? 132.998 126.603 238.480 1.00 107.96 ? 435  ASP A CB  1 
ATOM   2353 C  CG  . ASP A 1 445 ? 133.016 126.927 236.999 1.00 107.96 ? 435  ASP A CG  1 
ATOM   2354 O  OD1 . ASP A 1 445 ? 133.076 128.124 236.648 1.00 107.96 ? 435  ASP A OD1 1 
ATOM   2355 O  OD2 . ASP A 1 445 ? 132.974 125.982 236.183 1.00 107.96 ? 435  ASP A OD2 1 
ATOM   2356 N  N   . THR A 1 446 ? 132.293 129.881 238.888 1.00 103.51 ? 436  THR A N   1 
ATOM   2357 C  CA  . THR A 1 446 ? 131.259 130.899 239.027 1.00 103.51 ? 436  THR A CA  1 
ATOM   2358 C  C   . THR A 1 446 ? 130.182 130.783 237.952 1.00 103.51 ? 436  THR A C   1 
ATOM   2359 O  O   . THR A 1 446 ? 128.989 130.755 238.268 1.00 103.51 ? 436  THR A O   1 
ATOM   2360 C  CB  . THR A 1 446 ? 131.884 132.297 238.983 1.00 103.51 ? 436  THR A CB  1 
ATOM   2361 O  OG1 . THR A 1 446 ? 132.681 132.429 237.800 1.00 103.51 ? 436  THR A OG1 1 
ATOM   2362 C  CG2 . THR A 1 446 ? 132.756 132.530 240.205 1.00 103.51 ? 436  THR A CG2 1 
ATOM   2363 N  N   . GLN A 1 447 ? 130.584 130.716 236.686 1.00 98.86  ? 437  GLN A N   1 
ATOM   2364 C  CA  . GLN A 1 447 ? 129.656 130.751 235.566 1.00 98.86  ? 437  GLN A CA  1 
ATOM   2365 C  C   . GLN A 1 447 ? 129.504 129.373 234.936 1.00 98.86  ? 437  GLN A C   1 
ATOM   2366 O  O   . GLN A 1 447 ? 130.426 128.553 234.958 1.00 98.86  ? 437  GLN A O   1 
ATOM   2367 C  CB  . GLN A 1 447 ? 130.114 131.759 234.500 1.00 98.86  ? 437  GLN A CB  1 
ATOM   2368 C  CG  . GLN A 1 447 ? 131.205 131.287 233.537 1.00 98.86  ? 437  GLN A CG  1 
ATOM   2369 C  CD  . GLN A 1 447 ? 132.559 131.053 234.195 1.00 98.86  ? 437  GLN A CD  1 
ATOM   2370 O  OE1 . GLN A 1 447 ? 132.749 131.306 235.386 1.00 98.86  ? 437  GLN A OE1 1 
ATOM   2371 N  NE2 . GLN A 1 447 ? 133.513 130.569 233.409 1.00 98.86  ? 437  GLN A NE2 1 
ATOM   2372 N  N   . LYS A 1 448 ? 128.315 129.127 234.390 1.00 87.32  ? 438  LYS A N   1 
ATOM   2373 C  CA  . LYS A 1 448 ? 128.045 127.948 233.577 1.00 87.32  ? 438  LYS A CA  1 
ATOM   2374 C  C   . LYS A 1 448 ? 127.215 128.366 232.373 1.00 87.32  ? 438  LYS A C   1 
ATOM   2375 O  O   . LYS A 1 448 ? 126.224 129.087 232.516 1.00 87.32  ? 438  LYS A O   1 
ATOM   2376 C  CB  . LYS A 1 448 ? 127.315 126.857 234.374 1.00 87.32  ? 438  LYS A CB  1 
ATOM   2377 C  CG  . LYS A 1 448 ? 128.161 126.146 235.430 1.00 87.32  ? 438  LYS A CG  1 
ATOM   2378 C  CD  . LYS A 1 448 ? 129.430 125.523 234.851 1.00 87.32  ? 438  LYS A CD  1 
ATOM   2379 C  CE  . LYS A 1 448 ? 129.125 124.476 233.789 1.00 87.32  ? 438  LYS A CE  1 
ATOM   2380 N  NZ  . LYS A 1 448 ? 130.356 124.056 233.064 1.00 87.32  ? 438  LYS A NZ  1 
ATOM   2381 N  N   . GLU A 1 449 ? 127.619 127.911 231.192 1.00 68.24  ? 439  GLU A N   1 
ATOM   2382 C  CA  . GLU A 1 449 ? 126.968 128.284 229.945 1.00 68.24  ? 439  GLU A CA  1 
ATOM   2383 C  C   . GLU A 1 449 ? 126.073 127.146 229.476 1.00 68.24  ? 439  GLU A C   1 
ATOM   2384 O  O   . GLU A 1 449 ? 126.505 125.990 229.430 1.00 68.24  ? 439  GLU A O   1 
ATOM   2385 C  CB  . GLU A 1 449 ? 128.009 128.619 228.877 1.00 68.24  ? 439  GLU A CB  1 
ATOM   2386 C  CG  . GLU A 1 449 ? 127.502 128.546 227.451 1.00 68.24  ? 439  GLU A CG  1 
ATOM   2387 C  CD  . GLU A 1 449 ? 128.324 129.398 226.509 1.00 68.24  ? 439  GLU A CD  1 
ATOM   2388 O  OE1 . GLU A 1 449 ? 129.522 129.098 226.329 1.00 68.24  ? 439  GLU A OE1 1 
ATOM   2389 O  OE2 . GLU A 1 449 ? 127.779 130.375 225.957 1.00 68.24  ? 439  GLU A OE2 1 
ATOM   2390 N  N   . ILE A 1 450 ? 124.829 127.474 229.134 1.00 61.75  ? 440  ILE A N   1 
ATOM   2391 C  CA  . ILE A 1 450 ? 123.875 126.509 228.606 1.00 61.75  ? 440  ILE A CA  1 
ATOM   2392 C  C   . ILE A 1 450 ? 123.440 126.975 227.225 1.00 61.75  ? 440  ILE A C   1 
ATOM   2393 O  O   . ILE A 1 450 ? 123.513 128.163 226.895 1.00 61.75  ? 440  ILE A O   1 
ATOM   2394 C  CB  . ILE A 1 450 ? 122.659 126.328 229.541 1.00 61.75  ? 440  ILE A CB  1 
ATOM   2395 C  CG1 . ILE A 1 450 ? 121.825 127.607 229.584 1.00 61.75  ? 440  ILE A CG1 1 
ATOM   2396 C  CG2 . ILE A 1 450 ? 123.110 125.937 230.938 1.00 61.75  ? 440  ILE A CG2 1 
ATOM   2397 C  CD1 . ILE A 1 450 ? 120.669 127.559 230.549 1.00 61.75  ? 440  ILE A CD1 1 
ATOM   2398 N  N   . ARG A 1 451 ? 123.017 126.024 226.400 1.00 47.23  ? 441  ARG A N   1 
ATOM   2399 C  CA  . ARG A 1 451 ? 122.578 126.311 225.046 1.00 47.23  ? 441  ARG A CA  1 
ATOM   2400 C  C   . ARG A 1 451 ? 121.128 125.885 224.877 1.00 47.23  ? 441  ARG A C   1 
ATOM   2401 O  O   . ARG A 1 451 ? 120.670 124.929 225.508 1.00 47.23  ? 441  ARG A O   1 
ATOM   2402 C  CB  . ARG A 1 451 ? 123.455 125.595 224.015 1.00 47.23  ? 441  ARG A CB  1 
ATOM   2403 C  CG  . ARG A 1 451 ? 124.922 125.975 224.082 1.00 47.23  ? 441  ARG A CG  1 
ATOM   2404 C  CD  . ARG A 1 451 ? 125.142 127.394 223.600 1.00 47.23  ? 441  ARG A CD  1 
ATOM   2405 N  NE  . ARG A 1 451 ? 125.236 127.465 222.147 1.00 47.23  ? 441  ARG A NE  1 
ATOM   2406 C  CZ  . ARG A 1 451 ? 126.362 127.664 221.478 1.00 47.23  ? 441  ARG A CZ  1 
ATOM   2407 N  NH1 . ARG A 1 451 ? 127.519 127.816 222.102 1.00 47.23  ? 441  ARG A NH1 1 
ATOM   2408 N  NH2 . ARG A 1 451 ? 126.329 127.710 220.150 1.00 47.23  ? 441  ARG A NH2 1 
ATOM   2409 N  N   . VAL A 1 452 ? 120.403 126.609 224.028 1.00 41.83  ? 442  VAL A N   1 
ATOM   2410 C  CA  . VAL A 1 452 ? 119.033 126.253 223.673 1.00 41.83  ? 442  VAL A CA  1 
ATOM   2411 C  C   . VAL A 1 452 ? 118.905 126.314 222.158 1.00 41.83  ? 442  VAL A C   1 
ATOM   2412 O  O   . VAL A 1 452 ? 119.315 127.299 221.537 1.00 41.83  ? 442  VAL A O   1 
ATOM   2413 C  CB  . VAL A 1 452 ? 118.006 127.178 224.357 1.00 41.83  ? 442  VAL A CB  1 
ATOM   2414 C  CG1 . VAL A 1 452 ? 116.651 127.086 223.679 1.00 41.83  ? 442  VAL A CG1 1 
ATOM   2415 C  CG2 . VAL A 1 452 ? 117.879 126.826 225.830 1.00 41.83  ? 442  VAL A CG2 1 
ATOM   2416 N  N   . GLY A 1 453 ? 118.348 125.261 221.563 1.00 42.82  ? 443  GLY A N   1 
ATOM   2417 C  CA  . GLY A 1 453 ? 118.234 125.206 220.115 1.00 42.82  ? 443  GLY A CA  1 
ATOM   2418 C  C   . GLY A 1 453 ? 117.107 126.088 219.599 1.00 42.82  ? 443  GLY A C   1 
ATOM   2419 O  O   . GLY A 1 453 ? 116.044 126.202 220.208 1.00 42.82  ? 443  GLY A O   1 
ATOM   2420 N  N   . ILE A 1 454 ? 117.358 126.721 218.456 1.00 35.60  ? 444  ILE A N   1 
ATOM   2421 C  CA  . ILE A 1 454 ? 116.378 127.563 217.780 1.00 35.60  ? 444  ILE A CA  1 
ATOM   2422 C  C   . ILE A 1 454 ? 116.067 126.929 216.433 1.00 35.60  ? 444  ILE A C   1 
ATOM   2423 O  O   . ILE A 1 454 ? 116.947 126.833 215.569 1.00 35.60  ? 444  ILE A O   1 
ATOM   2424 C  CB  . ILE A 1 454 ? 116.883 129.003 217.607 1.00 35.60  ? 444  ILE A CB  1 
ATOM   2425 C  CG1 . ILE A 1 454 ? 117.136 129.644 218.970 1.00 35.60  ? 444  ILE A CG1 1 
ATOM   2426 C  CG2 . ILE A 1 454 ? 115.890 129.824 216.811 1.00 35.60  ? 444  ILE A CG2 1 
ATOM   2427 C  CD1 . ILE A 1 454 ? 115.912 129.703 219.849 1.00 35.60  ? 444  ILE A CD1 1 
ATOM   2428 N  N   . ILE A 1 455 ? 114.820 126.505 216.255 1.00 39.20  ? 445  ILE A N   1 
ATOM   2429 C  CA  . ILE A 1 455 ? 114.403 125.825 215.034 1.00 39.20  ? 445  ILE A CA  1 
ATOM   2430 C  C   . ILE A 1 455 ? 114.192 126.857 213.935 1.00 39.20  ? 445  ILE A C   1 
ATOM   2431 O  O   . ILE A 1 455 ? 113.474 127.845 214.123 1.00 39.20  ? 445  ILE A O   1 
ATOM   2432 C  CB  . ILE A 1 455 ? 113.129 125.002 215.280 1.00 39.20  ? 445  ILE A CB  1 
ATOM   2433 C  CG1 . ILE A 1 455 ? 113.444 123.787 216.154 1.00 39.20  ? 445  ILE A CG1 1 
ATOM   2434 C  CG2 . ILE A 1 455 ? 112.501 124.568 213.966 1.00 39.20  ? 445  ILE A CG2 1 
ATOM   2435 C  CD1 . ILE A 1 455 ? 112.220 123.046 216.634 1.00 39.20  ? 445  ILE A CD1 1 
ATOM   2436 N  N   . ASP A 1 456 ? 114.816 126.629 212.785 1.00 29.45  ? 446  ASP A N   1 
ATOM   2437 C  CA  . ASP A 1 456 ? 114.756 127.544 211.656 1.00 29.45  ? 446  ASP A CA  1 
ATOM   2438 C  C   . ASP A 1 456 ? 113.871 126.948 210.571 1.00 29.45  ? 446  ASP A C   1 
ATOM   2439 O  O   . ASP A 1 456 ? 114.053 125.790 210.183 1.00 29.45  ? 446  ASP A O   1 
ATOM   2440 C  CB  . ASP A 1 456 ? 116.157 127.818 211.109 1.00 29.45  ? 446  ASP A CB  1 
ATOM   2441 C  CG  . ASP A 1 456 ? 116.148 128.726 209.895 1.00 29.45  ? 446  ASP A CG  1 
ATOM   2442 O  OD1 . ASP A 1 456 ? 115.198 129.522 209.739 1.00 29.45  ? 446  ASP A OD1 1 
ATOM   2443 O  OD2 . ASP A 1 456 ? 117.100 128.645 209.091 1.00 29.45  ? 446  ASP A OD2 1 
ATOM   2444 N  N   . ASP A 1 457 ? 112.914 127.740 210.089 1.00 31.20  ? 447  ASP A N   1 
ATOM   2445 C  CA  . ASP A 1 457 ? 112.082 127.373 208.951 1.00 31.20  ? 447  ASP A CA  1 
ATOM   2446 C  C   . ASP A 1 457 ? 111.958 128.585 208.036 1.00 31.20  ? 447  ASP A C   1 
ATOM   2447 O  O   . ASP A 1 457 ? 112.480 129.663 208.330 1.00 31.20  ? 447  ASP A O   1 
ATOM   2448 C  CB  . ASP A 1 457 ? 110.716 126.837 209.403 1.00 31.20  ? 447  ASP A CB  1 
ATOM   2449 C  CG  . ASP A 1 457 ? 110.015 127.744 210.401 1.00 31.20  ? 447  ASP A CG  1 
ATOM   2450 O  OD1 . ASP A 1 457 ? 110.328 128.950 210.470 1.00 31.20  ? 447  ASP A OD1 1 
ATOM   2451 O  OD2 . ASP A 1 457 ? 109.136 127.239 211.130 1.00 31.20  ? 447  ASP A OD2 1 
ATOM   2452 N  N   . ASP A 1 458 ? 111.262 128.407 206.917 1.00 28.42  ? 448  ASP A N   1 
ATOM   2453 C  CA  . ASP A 1 458 ? 111.182 129.445 205.899 1.00 28.42  ? 448  ASP A CA  1 
ATOM   2454 C  C   . ASP A 1 458 ? 109.989 130.380 206.073 1.00 28.42  ? 448  ASP A C   1 
ATOM   2455 O  O   . ASP A 1 458 ? 109.892 131.372 205.344 1.00 28.42  ? 448  ASP A O   1 
ATOM   2456 C  CB  . ASP A 1 458 ? 111.127 128.806 204.510 1.00 28.42  ? 448  ASP A CB  1 
ATOM   2457 C  CG  . ASP A 1 458 ? 111.905 129.590 203.479 1.00 28.42  ? 448  ASP A CG  1 
ATOM   2458 O  OD1 . ASP A 1 458 ? 112.139 130.796 203.698 1.00 28.42  ? 448  ASP A OD1 1 
ATOM   2459 O  OD2 . ASP A 1 458 ? 112.288 128.999 202.449 1.00 28.42  ? 448  ASP A OD2 1 
ATOM   2460 N  N   . ILE A 1 459 ? 109.089 130.099 207.015 1.00 29.77  ? 449  ILE A N   1 
ATOM   2461 C  CA  . ILE A 1 459 ? 107.885 130.906 207.172 1.00 29.77  ? 449  ILE A CA  1 
ATOM   2462 C  C   . ILE A 1 459 ? 108.226 132.229 207.844 1.00 29.77  ? 449  ILE A C   1 
ATOM   2463 O  O   . ILE A 1 459 ? 108.974 132.273 208.830 1.00 29.77  ? 449  ILE A O   1 
ATOM   2464 C  CB  . ILE A 1 459 ? 106.836 130.131 207.984 1.00 29.77  ? 449  ILE A CB  1 
ATOM   2465 C  CG1 . ILE A 1 459 ? 106.494 128.819 207.290 1.00 29.77  ? 449  ILE A CG1 1 
ATOM   2466 C  CG2 . ILE A 1 459 ? 105.580 130.955 208.174 1.00 29.77  ? 449  ILE A CG2 1 
ATOM   2467 C  CD1 . ILE A 1 459 ? 105.794 127.846 208.191 1.00 29.77  ? 449  ILE A CD1 1 
ATOM   2468 N  N   . PHE A 1 460 ? 107.679 133.319 207.312 1.00 30.33  ? 450  PHE A N   1 
ATOM   2469 C  CA  . PHE A 1 460 ? 107.802 134.610 207.972 1.00 30.33  ? 450  PHE A CA  1 
ATOM   2470 C  C   . PHE A 1 460 ? 106.946 134.641 209.232 1.00 30.33  ? 450  PHE A C   1 
ATOM   2471 O  O   . PHE A 1 460 ? 105.791 134.208 209.229 1.00 30.33  ? 450  PHE A O   1 
ATOM   2472 C  CB  . PHE A 1 460 ? 107.389 135.735 207.021 1.00 30.33  ? 450  PHE A CB  1 
ATOM   2473 C  CG  . PHE A 1 460 ? 107.586 137.120 207.581 1.00 30.33  ? 450  PHE A CG  1 
ATOM   2474 C  CD1 . PHE A 1 460 ? 106.590 137.741 208.315 1.00 30.33  ? 450  PHE A CD1 1 
ATOM   2475 C  CD2 . PHE A 1 460 ? 108.768 137.801 207.363 1.00 30.33  ? 450  PHE A CD2 1 
ATOM   2476 C  CE1 . PHE A 1 460 ? 106.771 139.006 208.823 1.00 30.33  ? 450  PHE A CE1 1 
ATOM   2477 C  CE2 . PHE A 1 460 ? 108.954 139.070 207.869 1.00 30.33  ? 450  PHE A CE2 1 
ATOM   2478 C  CZ  . PHE A 1 460 ? 107.954 139.672 208.600 1.00 30.33  ? 450  PHE A CZ  1 
ATOM   2479 N  N   . GLU A 1 461 ? 107.523 135.155 210.316 1.00 36.29  ? 451  GLU A N   1 
ATOM   2480 C  CA  . GLU A 1 461 ? 106.819 135.329 211.579 1.00 36.29  ? 451  GLU A CA  1 
ATOM   2481 C  C   . GLU A 1 461 ? 107.223 136.669 212.176 1.00 36.29  ? 451  GLU A C   1 
ATOM   2482 O  O   . GLU A 1 461 ? 108.152 137.329 211.704 1.00 36.29  ? 451  GLU A O   1 
ATOM   2483 C  CB  . GLU A 1 461 ? 107.124 134.201 212.577 1.00 36.29  ? 451  GLU A CB  1 
ATOM   2484 C  CG  . GLU A 1 461 ? 107.021 132.784 212.028 1.00 36.29  ? 451  GLU A CG  1 
ATOM   2485 C  CD  . GLU A 1 461 ? 107.728 131.772 212.907 1.00 36.29  ? 451  GLU A CD  1 
ATOM   2486 O  OE1 . GLU A 1 461 ? 107.342 131.642 214.086 1.00 36.29  ? 451  GLU A OE1 1 
ATOM   2487 O  OE2 . GLU A 1 461 ? 108.678 131.119 212.425 1.00 36.29  ? 451  GLU A OE2 1 
ATOM   2488 N  N   . GLU A 1 462 ? 106.507 137.078 213.218 1.00 42.59  ? 452  GLU A N   1 
ATOM   2489 C  CA  . GLU A 1 462 ? 106.893 138.254 213.977 1.00 42.59  ? 452  GLU A CA  1 
ATOM   2490 C  C   . GLU A 1 462 ? 107.882 137.853 215.068 1.00 42.59  ? 452  GLU A C   1 
ATOM   2491 O  O   . GLU A 1 462 ? 108.216 136.678 215.238 1.00 42.59  ? 452  GLU A O   1 
ATOM   2492 C  CB  . GLU A 1 462 ? 105.665 138.944 214.567 1.00 42.59  ? 452  GLU A CB  1 
ATOM   2493 C  CG  . GLU A 1 462 ? 104.859 139.744 213.559 1.00 42.59  ? 452  GLU A CG  1 
ATOM   2494 C  CD  . GLU A 1 462 ? 103.757 140.558 214.207 1.00 42.59  ? 452  GLU A CD  1 
ATOM   2495 O  OE1 . GLU A 1 462 ? 103.462 140.323 215.398 1.00 42.59  ? 452  GLU A OE1 1 
ATOM   2496 O  OE2 . GLU A 1 462 ? 103.187 141.436 213.528 1.00 42.59  ? 452  GLU A OE2 1 
ATOM   2497 N  N   . ASP A 1 463 ? 108.370 138.844 215.811 1.00 44.31  ? 453  ASP A N   1 
ATOM   2498 C  CA  . ASP A 1 463 ? 109.276 138.573 216.919 1.00 44.31  ? 453  ASP A CA  1 
ATOM   2499 C  C   . ASP A 1 463 ? 108.540 137.818 218.017 1.00 44.31  ? 453  ASP A C   1 
ATOM   2500 O  O   . ASP A 1 463 ? 107.414 138.172 218.378 1.00 44.31  ? 453  ASP A O   1 
ATOM   2501 C  CB  . ASP A 1 463 ? 109.850 139.877 217.466 1.00 44.31  ? 453  ASP A CB  1 
ATOM   2502 C  CG  . ASP A 1 463 ? 110.654 140.634 216.434 1.00 44.31  ? 453  ASP A CG  1 
ATOM   2503 O  OD1 . ASP A 1 463 ? 110.996 140.036 215.393 1.00 44.31  ? 453  ASP A OD1 1 
ATOM   2504 O  OD2 . ASP A 1 463 ? 110.952 141.824 216.664 1.00 44.31  ? 453  ASP A OD2 1 
ATOM   2505 N  N   . GLU A 1 464 ? 109.171 136.773 218.548 1.00 47.41  ? 454  GLU A N   1 
ATOM   2506 C  CA  . GLU A 1 464 ? 108.526 135.923 219.540 1.00 47.41  ? 454  GLU A CA  1 
ATOM   2507 C  C   . GLU A 1 464 ? 109.445 135.760 220.742 1.00 47.41  ? 454  GLU A C   1 
ATOM   2508 O  O   . GLU A 1 464 ? 110.615 136.137 220.704 1.00 47.41  ? 454  GLU A O   1 
ATOM   2509 C  CB  . GLU A 1 464 ? 108.154 134.558 218.945 1.00 47.41  ? 454  GLU A CB  1 
ATOM   2510 C  CG  . GLU A 1 464 ? 107.123 134.640 217.827 1.00 47.41  ? 454  GLU A CG  1 
ATOM   2511 C  CD  . GLU A 1 464 ? 106.816 133.292 217.204 1.00 47.41  ? 454  GLU A CD  1 
ATOM   2512 O  OE1 . GLU A 1 464 ? 107.537 132.321 217.501 1.00 47.41  ? 454  GLU A OE1 1 
ATOM   2513 O  OE2 . GLU A 1 464 ? 105.848 133.203 216.420 1.00 47.41  ? 454  GLU A OE2 1 
ATOM   2514 N  N   . ASN A 1 465 ? 108.907 135.220 221.834 1.00 51.01  ? 455  ASN A N   1 
ATOM   2515 C  CA  . ASN A 1 465 ? 109.710 135.007 223.029 1.00 51.01  ? 455  ASN A CA  1 
ATOM   2516 C  C   . ASN A 1 465 ? 109.300 133.719 223.729 1.00 51.01  ? 455  ASN A C   1 
ATOM   2517 O  O   . ASN A 1 465 ? 108.149 133.285 223.650 1.00 51.01  ? 455  ASN A O   1 
ATOM   2518 C  CB  . ASN A 1 465 ? 109.617 136.204 223.997 1.00 51.01  ? 455  ASN A CB  1 
ATOM   2519 C  CG  . ASN A 1 465 ? 108.185 136.601 224.321 1.00 51.01  ? 455  ASN A CG  1 
ATOM   2520 O  OD1 . ASN A 1 465 ? 107.370 135.782 224.742 1.00 51.01  ? 455  ASN A OD1 1 
ATOM   2521 N  ND2 . ASN A 1 465 ? 107.878 137.879 224.130 1.00 51.01  ? 455  ASN A ND2 1 
ATOM   2522 N  N   . PHE A 1 466 ? 110.271 133.108 224.406 1.00 51.35  ? 456  PHE A N   1 
ATOM   2523 C  CA  . PHE A 1 466 ? 110.024 131.939 225.241 1.00 51.35  ? 456  PHE A CA  1 
ATOM   2524 C  C   . PHE A 1 466 ? 110.814 132.075 226.534 1.00 51.35  ? 456  PHE A C   1 
ATOM   2525 O  O   . PHE A 1 466 ? 111.890 132.681 226.560 1.00 51.35  ? 456  PHE A O   1 
ATOM   2526 C  CB  . PHE A 1 466 ? 110.381 130.626 224.525 1.00 51.35  ? 456  PHE A CB  1 
ATOM   2527 C  CG  . PHE A 1 466 ? 111.824 130.516 224.109 1.00 51.35  ? 456  PHE A CG  1 
ATOM   2528 C  CD1 . PHE A 1 466 ? 112.254 131.033 222.899 1.00 51.35  ? 456  PHE A CD1 1 
ATOM   2529 C  CD2 . PHE A 1 466 ? 112.741 129.857 224.912 1.00 51.35  ? 456  PHE A CD2 1 
ATOM   2530 C  CE1 . PHE A 1 466 ? 113.577 130.919 222.513 1.00 51.35  ? 456  PHE A CE1 1 
ATOM   2531 C  CE2 . PHE A 1 466 ? 114.063 129.739 224.528 1.00 51.35  ? 456  PHE A CE2 1 
ATOM   2532 C  CZ  . PHE A 1 466 ? 114.480 130.269 223.326 1.00 51.35  ? 456  PHE A CZ  1 
ATOM   2533 N  N   . LEU A 1 467 ? 110.272 131.514 227.613 1.00 65.33  ? 457  LEU A N   1 
ATOM   2534 C  CA  . LEU A 1 467 ? 110.857 131.715 228.929 1.00 65.33  ? 457  LEU A CA  1 
ATOM   2535 C  C   . LEU A 1 467 ? 111.752 130.543 229.307 1.00 65.33  ? 457  LEU A C   1 
ATOM   2536 O  O   . LEU A 1 467 ? 111.648 129.446 228.761 1.00 65.33  ? 457  LEU A O   1 
ATOM   2537 C  CB  . LEU A 1 467 ? 109.766 131.901 229.986 1.00 65.33  ? 457  LEU A CB  1 
ATOM   2538 C  CG  . LEU A 1 467 ? 108.731 132.995 229.717 1.00 65.33  ? 457  LEU A CG  1 
ATOM   2539 C  CD1 . LEU A 1 467 ? 107.826 133.180 230.924 1.00 65.33  ? 457  LEU A CD1 1 
ATOM   2540 C  CD2 . LEU A 1 467 ? 109.407 134.305 229.347 1.00 65.33  ? 457  LEU A CD2 1 
ATOM   2541 N  N   . VAL A 1 468 ? 112.646 130.797 230.257 1.00 71.65  ? 458  VAL A N   1 
ATOM   2542 C  CA  . VAL A 1 468 ? 113.511 129.776 230.836 1.00 71.65  ? 458  VAL A CA  1 
ATOM   2543 C  C   . VAL A 1 468 ? 113.428 129.914 232.348 1.00 71.65  ? 458  VAL A C   1 
ATOM   2544 O  O   . VAL A 1 468 ? 113.691 130.997 232.887 1.00 71.65  ? 458  VAL A O   1 
ATOM   2545 C  CB  . VAL A 1 468 ? 114.966 129.903 230.355 1.00 71.65  ? 458  VAL A CB  1 
ATOM   2546 C  CG1 . VAL A 1 468 ? 115.888 129.073 231.229 1.00 71.65  ? 458  VAL A CG1 1 
ATOM   2547 C  CG2 . VAL A 1 468 ? 115.082 129.477 228.901 1.00 71.65  ? 458  VAL A CG2 1 
ATOM   2548 N  N   . HIS A 1 469 ? 113.065 128.828 233.027 1.00 80.87  ? 459  HIS A N   1 
ATOM   2549 C  CA  . HIS A 1 469 ? 112.851 128.821 234.466 1.00 80.87  ? 459  HIS A CA  1 
ATOM   2550 C  C   . HIS A 1 469 ? 113.904 127.954 235.142 1.00 80.87  ? 459  HIS A C   1 
ATOM   2551 O  O   . HIS A 1 469 ? 114.140 126.812 234.724 1.00 80.87  ? 459  HIS A O   1 
ATOM   2552 C  CB  . HIS A 1 469 ? 111.452 128.301 234.812 1.00 80.87  ? 459  HIS A CB  1 
ATOM   2553 C  CG  . HIS A 1 469 ? 110.338 129.149 234.282 1.00 80.87  ? 459  HIS A CG  1 
ATOM   2554 N  ND1 . HIS A 1 469 ? 109.390 129.726 235.100 1.00 80.87  ? 459  HIS A ND1 1 
ATOM   2555 C  CD2 . HIS A 1 469 ? 110.014 129.512 233.019 1.00 80.87  ? 459  HIS A CD2 1 
ATOM   2556 C  CE1 . HIS A 1 469 ? 108.533 130.410 234.364 1.00 80.87  ? 459  HIS A CE1 1 
ATOM   2557 N  NE2 . HIS A 1 469 ? 108.889 130.297 233.097 1.00 80.87  ? 459  HIS A NE2 1 
ATOM   2558 N  N   . LEU A 1 470 ? 114.530 128.501 236.181 1.00 84.98  ? 460  LEU A N   1 
ATOM   2559 C  CA  . LEU A 1 470 ? 115.454 127.769 237.035 1.00 84.98  ? 460  LEU A CA  1 
ATOM   2560 C  C   . LEU A 1 470 ? 114.730 127.351 238.307 1.00 84.98  ? 460  LEU A C   1 
ATOM   2561 O  O   . LEU A 1 470 ? 113.907 128.102 238.838 1.00 84.98  ? 460  LEU A O   1 
ATOM   2562 C  CB  . LEU A 1 470 ? 116.673 128.621 237.394 1.00 84.98  ? 460  LEU A CB  1 
ATOM   2563 C  CG  . LEU A 1 470 ? 117.345 129.471 236.315 1.00 84.98  ? 460  LEU A CG  1 
ATOM   2564 C  CD1 . LEU A 1 470 ? 118.618 130.091 236.863 1.00 84.98  ? 460  LEU A CD1 1 
ATOM   2565 C  CD2 . LEU A 1 470 ? 117.654 128.651 235.081 1.00 84.98  ? 460  LEU A CD2 1 
ATOM   2566 N  N   . SER A 1 471 ? 115.041 126.154 238.796 1.00 94.17  ? 461  SER A N   1 
ATOM   2567 C  CA  . SER A 1 471 ? 114.358 125.619 239.966 1.00 94.17  ? 461  SER A CA  1 
ATOM   2568 C  C   . SER A 1 471 ? 115.225 124.539 240.603 1.00 94.17  ? 461  SER A C   1 
ATOM   2569 O  O   . SER A 1 471 ? 116.288 124.178 240.086 1.00 94.17  ? 461  SER A O   1 
ATOM   2570 C  CB  . SER A 1 471 ? 112.977 125.072 239.593 1.00 94.17  ? 461  SER A CB  1 
ATOM   2571 O  OG  . SER A 1 471 ? 112.285 124.612 240.740 1.00 94.17  ? 461  SER A OG  1 
ATOM   2572 N  N   . ASN A 1 472 ? 114.758 124.052 241.755 1.00 101.68 ? 462  ASN A N   1 
ATOM   2573 C  CA  . ASN A 1 472 ? 115.309 122.888 242.453 1.00 101.68 ? 462  ASN A CA  1 
ATOM   2574 C  C   . ASN A 1 472 ? 116.804 123.041 242.728 1.00 101.68 ? 462  ASN A C   1 
ATOM   2575 O  O   . ASN A 1 472 ? 117.622 122.190 242.371 1.00 101.68 ? 462  ASN A O   1 
ATOM   2576 C  CB  . ASN A 1 472 ? 115.022 121.602 241.676 1.00 101.68 ? 462  ASN A CB  1 
ATOM   2577 C  CG  . ASN A 1 472 ? 115.161 120.360 242.535 1.00 101.68 ? 462  ASN A CG  1 
ATOM   2578 O  OD1 . ASN A 1 472 ? 114.405 120.162 243.488 1.00 101.68 ? 462  ASN A OD1 1 
ATOM   2579 N  ND2 . ASN A 1 472 ? 116.134 119.518 242.207 1.00 101.68 ? 462  ASN A ND2 1 
ATOM   2580 N  N   . VAL A 1 473 ? 117.163 124.149 243.364 1.00 104.05 ? 463  VAL A N   1 
ATOM   2581 C  CA  . VAL A 1 473 ? 118.538 124.357 243.800 1.00 104.05 ? 463  VAL A CA  1 
ATOM   2582 C  C   . VAL A 1 473 ? 118.776 123.530 245.054 1.00 104.05 ? 463  VAL A C   1 
ATOM   2583 O  O   . VAL A 1 473 ? 118.032 123.640 246.036 1.00 104.05 ? 463  VAL A O   1 
ATOM   2584 C  CB  . VAL A 1 473 ? 118.811 125.848 244.052 1.00 104.05 ? 463  VAL A CB  1 
ATOM   2585 C  CG1 . VAL A 1 473 ? 120.300 126.088 244.245 1.00 104.05 ? 463  VAL A CG1 1 
ATOM   2586 C  CG2 . VAL A 1 473 ? 118.273 126.688 242.904 1.00 104.05 ? 463  VAL A CG2 1 
ATOM   2587 N  N   . LYS A 1 474 ? 119.812 122.695 245.027 1.00 103.38 ? 464  LYS A N   1 
ATOM   2588 C  CA  . LYS A 1 474 ? 120.109 121.807 246.141 1.00 103.38 ? 464  LYS A CA  1 
ATOM   2589 C  C   . LYS A 1 474 ? 121.592 121.873 246.473 1.00 103.38 ? 464  LYS A C   1 
ATOM   2590 O  O   . LYS A 1 474 ? 122.425 122.177 245.619 1.00 103.38 ? 464  LYS A O   1 
ATOM   2591 C  CB  . LYS A 1 474 ? 119.709 120.358 245.830 1.00 103.38 ? 464  LYS A CB  1 
ATOM   2592 C  CG  . LYS A 1 474 ? 118.230 120.065 246.024 1.00 103.38 ? 464  LYS A CG  1 
ATOM   2593 C  CD  . LYS A 1 474 ? 117.986 118.585 246.278 1.00 103.38 ? 464  LYS A CD  1 
ATOM   2594 C  CE  . LYS A 1 474 ? 118.706 117.714 245.259 1.00 103.38 ? 464  LYS A CE  1 
ATOM   2595 N  NZ  . LYS A 1 474 ? 118.540 116.263 245.549 1.00 103.38 ? 464  LYS A NZ  1 
ATOM   2596 N  N   . VAL A 1 475 ? 121.915 121.570 247.728 1.00 103.83 ? 465  VAL A N   1 
ATOM   2597 C  CA  . VAL A 1 475 ? 123.284 121.597 248.231 1.00 103.83 ? 465  VAL A CA  1 
ATOM   2598 C  C   . VAL A 1 475 ? 123.738 120.163 248.456 1.00 103.83 ? 465  VAL A C   1 
ATOM   2599 O  O   . VAL A 1 475 ? 123.040 119.381 249.114 1.00 103.83 ? 465  VAL A O   1 
ATOM   2600 C  CB  . VAL A 1 475 ? 123.391 122.417 249.529 1.00 103.83 ? 465  VAL A CB  1 
ATOM   2601 C  CG1 . VAL A 1 475 ? 124.822 122.416 250.047 1.00 103.83 ? 465  VAL A CG1 1 
ATOM   2602 C  CG2 . VAL A 1 475 ? 122.897 123.835 249.304 1.00 103.83 ? 465  VAL A CG2 1 
ATOM   2603 N  N   . SER A 1 476 ? 124.903 119.815 247.913 1.00 103.86 ? 466  SER A N   1 
ATOM   2604 C  CA  . SER A 1 476 ? 125.463 118.477 248.041 1.00 103.86 ? 466  SER A CA  1 
ATOM   2605 C  C   . SER A 1 476 ? 126.638 118.505 249.008 1.00 103.86 ? 466  SER A C   1 
ATOM   2606 O  O   . SER A 1 476 ? 127.543 119.334 248.862 1.00 103.86 ? 466  SER A O   1 
ATOM   2607 C  CB  . SER A 1 476 ? 125.914 117.940 246.682 1.00 103.86 ? 466  SER A CB  1 
ATOM   2608 O  OG  . SER A 1 476 ? 126.405 116.616 246.794 1.00 103.86 ? 466  SER A OG  1 
ATOM   2609 N  N   . SER A 1 477 ? 126.613 117.596 249.983 1.00 97.16  ? 467  SER A N   1 
ATOM   2610 C  CA  . SER A 1 477 ? 127.668 117.440 250.988 1.00 97.16  ? 467  SER A CA  1 
ATOM   2611 C  C   . SER A 1 477 ? 127.957 118.734 251.747 1.00 97.16  ? 467  SER A C   1 
ATOM   2612 O  O   . SER A 1 477 ? 127.061 119.548 251.970 1.00 97.16  ? 467  SER A O   1 
ATOM   2613 C  CB  . SER A 1 477 ? 128.954 116.917 250.339 1.00 97.16  ? 467  SER A CB  1 
ATOM   2614 O  OG  . SER A 1 477 ? 128.728 115.679 249.685 1.00 97.16  ? 467  SER A OG  1 
ATOM   2615 N  N   . THR A 1 492 ? 118.245 128.548 252.733 1.00 100.63 ? 482  THR A N   1 
ATOM   2616 C  CA  . THR A 1 492 ? 119.296 127.623 253.139 1.00 100.63 ? 482  THR A CA  1 
ATOM   2617 C  C   . THR A 1 492 ? 120.667 128.135 252.708 1.00 100.63 ? 482  THR A C   1 
ATOM   2618 O  O   . THR A 1 492 ? 120.878 129.342 252.590 1.00 100.63 ? 482  THR A O   1 
ATOM   2619 C  CB  . THR A 1 492 ? 119.072 126.218 252.549 1.00 100.63 ? 482  THR A CB  1 
ATOM   2620 O  OG1 . THR A 1 492 ? 119.161 126.278 251.120 1.00 100.63 ? 482  THR A OG1 1 
ATOM   2621 C  CG2 . THR A 1 492 ? 117.703 125.686 252.945 1.00 100.63 ? 482  THR A CG2 1 
ATOM   2622 N  N   . LEU A 1 493 ? 121.599 127.205 252.481 1.00 102.22 ? 483  LEU A N   1 
ATOM   2623 C  CA  . LEU A 1 493 ? 122.938 127.590 252.044 1.00 102.22 ? 483  LEU A CA  1 
ATOM   2624 C  C   . LEU A 1 493 ? 122.918 128.168 250.634 1.00 102.22 ? 483  LEU A C   1 
ATOM   2625 O  O   . LEU A 1 493 ? 123.656 129.114 250.335 1.00 102.22 ? 483  LEU A O   1 
ATOM   2626 C  CB  . LEU A 1 493 ? 123.888 126.393 252.121 1.00 102.22 ? 483  LEU A CB  1 
ATOM   2627 C  CG  . LEU A 1 493 ? 124.628 126.127 253.439 1.00 102.22 ? 483  LEU A CG  1 
ATOM   2628 C  CD1 . LEU A 1 493 ? 125.509 127.314 253.804 1.00 102.22 ? 483  LEU A CD1 1 
ATOM   2629 C  CD2 . LEU A 1 493 ? 123.682 125.778 254.584 1.00 102.22 ? 483  LEU A CD2 1 
ATOM   2630 N  N   . ALA A 1 494 ? 122.082 127.616 249.756 1.00 100.87 ? 484  ALA A N   1 
ATOM   2631 C  CA  . ALA A 1 494 ? 121.955 128.084 248.381 1.00 100.87 ? 484  ALA A CA  1 
ATOM   2632 C  C   . ALA A 1 494 ? 120.564 128.666 248.183 1.00 100.87 ? 484  ALA A C   1 
ATOM   2633 O  O   . ALA A 1 494 ? 119.561 127.985 248.426 1.00 100.87 ? 484  ALA A O   1 
ATOM   2634 C  CB  . ALA A 1 494 ? 122.208 126.951 247.385 1.00 100.87 ? 484  ALA A CB  1 
ATOM   2635 N  N   . CYS A 1 495 ? 120.506 129.918 247.737 1.00 100.73 ? 485  CYS A N   1 
ATOM   2636 C  CA  . CYS A 1 495 ? 119.249 130.588 247.445 1.00 100.73 ? 485  CYS A CA  1 
ATOM   2637 C  C   . CYS A 1 495 ? 119.281 131.134 246.026 1.00 100.73 ? 485  CYS A C   1 
ATOM   2638 O  O   . CYS A 1 495 ? 120.321 131.590 245.541 1.00 100.73 ? 485  CYS A O   1 
ATOM   2639 C  CB  . CYS A 1 495 ? 118.966 131.726 248.436 1.00 100.73 ? 485  CYS A CB  1 
ATOM   2640 S  SG  . CYS A 1 495 ? 118.620 131.189 250.126 1.00 100.73 ? 485  CYS A SG  1 
ATOM   2641 N  N   . LEU A 1 496 ? 118.125 131.087 245.368 1.00 94.92  ? 486  LEU A N   1 
ATOM   2642 C  CA  . LEU A 1 496 ? 118.013 131.505 243.980 1.00 94.92  ? 486  LEU A CA  1 
ATOM   2643 C  C   . LEU A 1 496 ? 118.060 133.026 243.876 1.00 94.92  ? 486  LEU A C   1 
ATOM   2644 O  O   . LEU A 1 496 ? 117.558 133.745 244.745 1.00 94.92  ? 486  LEU A O   1 
ATOM   2645 C  CB  . LEU A 1 496 ? 116.708 130.987 243.373 1.00 94.92  ? 486  LEU A CB  1 
ATOM   2646 C  CG  . LEU A 1 496 ? 116.641 130.669 241.876 1.00 94.92  ? 486  LEU A CG  1 
ATOM   2647 C  CD1 . LEU A 1 496 ? 117.988 130.229 241.328 1.00 94.92  ? 486  LEU A CD1 1 
ATOM   2648 C  CD2 . LEU A 1 496 ? 115.600 129.605 241.610 1.00 94.92  ? 486  LEU A CD2 1 
ATOM   2649 N  N   . GLY A 1 497 ? 118.670 133.511 242.796 1.00 92.92  ? 487  GLY A N   1 
ATOM   2650 C  CA  . GLY A 1 497 ? 118.762 134.940 242.577 1.00 92.92  ? 487  GLY A CA  1 
ATOM   2651 C  C   . GLY A 1 497 ? 117.443 135.556 242.152 1.00 92.92  ? 487  GLY A C   1 
ATOM   2652 O  O   . GLY A 1 497 ? 116.503 134.873 241.741 1.00 92.92  ? 487  GLY A O   1 
ATOM   2653 N  N   . SER A 1 498 ? 117.376 136.883 242.276 1.00 86.53  ? 488  SER A N   1 
ATOM   2654 C  CA  . SER A 1 498 ? 116.169 137.603 241.875 1.00 86.53  ? 488  SER A CA  1 
ATOM   2655 C  C   . SER A 1 498 ? 115.838 137.480 240.388 1.00 86.53  ? 488  SER A C   1 
ATOM   2656 O  O   . SER A 1 498 ? 114.671 137.183 240.077 1.00 86.53  ? 488  SER A O   1 
ATOM   2657 C  CB  . SER A 1 498 ? 116.273 139.075 242.302 1.00 86.53  ? 488  SER A CB  1 
ATOM   2658 O  OG  . SER A 1 498 ? 115.986 139.232 243.680 1.00 86.53  ? 488  SER A OG  1 
ATOM   2659 N  N   . PRO A 1 499 ? 116.774 137.666 239.424 1.00 85.40  ? 489  PRO A N   1 
ATOM   2660 C  CA  . PRO A 1 499 ? 116.362 137.414 238.024 1.00 85.40  ? 489  PRO A CA  1 
ATOM   2661 C  C   . PRO A 1 499 ? 116.455 135.931 237.676 1.00 85.40  ? 489  PRO A C   1 
ATOM   2662 O  O   . PRO A 1 499 ? 117.292 135.480 236.882 1.00 85.40  ? 489  PRO A O   1 
ATOM   2663 C  CB  . PRO A 1 499 ? 117.341 138.281 237.230 1.00 85.40  ? 489  PRO A CB  1 
ATOM   2664 C  CG  . PRO A 1 499 ? 118.566 138.292 238.045 1.00 85.40  ? 489  PRO A CG  1 
ATOM   2665 C  CD  . PRO A 1 499 ? 118.160 138.172 239.488 1.00 85.40  ? 489  PRO A CD  1 
ATOM   2666 N  N   . SER A 1 500 ? 115.577 135.145 238.305 1.00 80.49  ? 490  SER A N   1 
ATOM   2667 C  CA  . SER A 1 500 ? 115.593 133.699 238.108 1.00 80.49  ? 490  SER A CA  1 
ATOM   2668 C  C   . SER A 1 500 ? 115.175 133.318 236.693 1.00 80.49  ? 490  SER A C   1 
ATOM   2669 O  O   . SER A 1 500 ? 115.792 132.443 236.074 1.00 80.49  ? 490  SER A O   1 
ATOM   2670 C  CB  . SER A 1 500 ? 114.680 133.023 239.128 1.00 80.49  ? 490  SER A CB  1 
ATOM   2671 O  OG  . SER A 1 500 ? 114.714 131.614 238.987 1.00 80.49  ? 490  SER A OG  1 
ATOM   2672 N  N   . THR A 1 501 ? 114.134 133.956 236.164 1.00 73.81  ? 491  THR A N   1 
ATOM   2673 C  CA  . THR A 1 501 ? 113.584 133.588 234.866 1.00 73.81  ? 491  THR A CA  1 
ATOM   2674 C  C   . THR A 1 501 ? 114.184 134.449 233.764 1.00 73.81  ? 491  THR A C   1 
ATOM   2675 O  O   . THR A 1 501 ? 114.434 135.642 233.956 1.00 73.81  ? 491  THR A O   1 
ATOM   2676 C  CB  . THR A 1 501 ? 112.062 133.731 234.861 1.00 73.81  ? 491  THR A CB  1 
ATOM   2677 O  OG1 . THR A 1 501 ? 111.709 135.073 234.504 1.00 73.81  ? 491  THR A OG1 1 
ATOM   2678 C  CG2 . THR A 1 501 ? 111.494 133.412 236.236 1.00 73.81  ? 491  THR A CG2 1 
ATOM   2679 N  N   . ALA A 1 502 ? 114.413 133.833 232.609 1.00 68.78  ? 492  ALA A N   1 
ATOM   2680 C  CA  . ALA A 1 502 ? 114.940 134.525 231.442 1.00 68.78  ? 492  ALA A CA  1 
ATOM   2681 C  C   . ALA A 1 502 ? 113.899 134.540 230.329 1.00 68.78  ? 492  ALA A C   1 
ATOM   2682 O  O   . ALA A 1 502 ? 113.056 133.646 230.239 1.00 68.78  ? 492  ALA A O   1 
ATOM   2683 C  CB  . ALA A 1 502 ? 116.228 133.867 230.941 1.00 68.78  ? 492  ALA A CB  1 
ATOM   2684 N  N   . THR A 1 503 ? 113.969 135.562 229.480 1.00 55.91  ? 493  THR A N   1 
ATOM   2685 C  CA  . THR A 1 503 ? 113.017 135.765 228.389 1.00 55.91  ? 493  THR A CA  1 
ATOM   2686 C  C   . THR A 1 503 ? 113.801 135.891 227.085 1.00 55.91  ? 493  THR A C   1 
ATOM   2687 O  O   . THR A 1 503 ? 114.289 136.971 226.746 1.00 55.91  ? 493  THR A O   1 
ATOM   2688 C  CB  . THR A 1 503 ? 112.156 137.002 228.641 1.00 55.91  ? 493  THR A CB  1 
ATOM   2689 O  OG1 . THR A 1 503 ? 111.461 136.856 229.885 1.00 55.91  ? 493  THR A OG1 1 
ATOM   2690 C  CG2 . THR A 1 503 ? 111.140 137.184 227.524 1.00 55.91  ? 493  THR A CG2 1 
ATOM   2691 N  N   . VAL A 1 504 ? 113.932 134.787 226.355 1.00 47.98  ? 494  VAL A N   1 
ATOM   2692 C  CA  . VAL A 1 504 ? 114.677 134.800 225.103 1.00 47.98  ? 494  VAL A CA  1 
ATOM   2693 C  C   . VAL A 1 504 ? 113.757 135.241 223.976 1.00 47.98  ? 494  VAL A C   1 
ATOM   2694 O  O   . VAL A 1 504 ? 112.606 134.795 223.882 1.00 47.98  ? 494  VAL A O   1 
ATOM   2695 C  CB  . VAL A 1 504 ? 115.285 133.416 224.822 1.00 47.98  ? 494  VAL A CB  1 
ATOM   2696 C  CG1 . VAL A 1 504 ? 116.322 133.505 223.715 1.00 47.98  ? 494  VAL A CG1 1 
ATOM   2697 C  CG2 . VAL A 1 504 ? 115.896 132.839 226.087 1.00 47.98  ? 494  VAL A CG2 1 
ATOM   2698 N  N   . THR A 1 505 ? 114.262 136.119 223.113 1.00 43.65  ? 495  THR A N   1 
ATOM   2699 C  CA  . THR A 1 505 ? 113.502 136.665 221.999 1.00 43.65  ? 495  THR A CA  1 
ATOM   2700 C  C   . THR A 1 505 ? 114.120 136.230 220.678 1.00 43.65  ? 495  THR A C   1 
ATOM   2701 O  O   . THR A 1 505 ? 115.342 136.265 220.509 1.00 43.65  ? 495  THR A O   1 
ATOM   2702 C  CB  . THR A 1 505 ? 113.447 138.194 222.055 1.00 43.65  ? 495  THR A CB  1 
ATOM   2703 O  OG1 . THR A 1 505 ? 114.687 138.700 222.561 1.00 43.65  ? 495  THR A OG1 1 
ATOM   2704 C  CG2 . THR A 1 505 ? 112.310 138.653 222.955 1.00 43.65  ? 495  THR A CG2 1 
ATOM   2705 N  N   . ILE A 1 506 ? 113.261 135.826 219.747 1.00 35.76  ? 496  ILE A N   1 
ATOM   2706 C  CA  . ILE A 1 506 ? 113.657 135.382 218.417 1.00 35.76  ? 496  ILE A CA  1 
ATOM   2707 C  C   . ILE A 1 506 ? 113.134 136.387 217.403 1.00 35.76  ? 496  ILE A C   1 
ATOM   2708 O  O   . ILE A 1 506 ? 111.934 136.702 217.390 1.00 35.76  ? 496  ILE A O   1 
ATOM   2709 C  CB  . ILE A 1 506 ? 113.120 133.975 218.107 1.00 35.76  ? 496  ILE A CB  1 
ATOM   2710 C  CG1 . ILE A 1 506 ? 113.416 133.021 219.259 1.00 35.76  ? 496  ILE A CG1 1 
ATOM   2711 C  CG2 . ILE A 1 506 ? 113.734 133.449 216.827 1.00 35.76  ? 496  ILE A CG2 1 
ATOM   2712 C  CD1 . ILE A 1 506 ? 112.579 131.774 219.222 1.00 35.76  ? 496  ILE A CD1 1 
ATOM   2713 N  N   . PHE A 1 507 ? 114.039 136.895 216.565 1.00 40.44  ? 497  PHE A N   1 
ATOM   2714 C  CA  . PHE A 1 507 ? 113.706 137.795 215.468 1.00 40.44  ? 497  PHE A CA  1 
ATOM   2715 C  C   . PHE A 1 507 ? 113.673 136.983 214.179 1.00 40.44  ? 497  PHE A C   1 
ATOM   2716 O  O   . PHE A 1 507 ? 114.718 136.546 213.690 1.00 40.44  ? 497  PHE A O   1 
ATOM   2717 C  CB  . PHE A 1 507 ? 114.725 138.927 215.350 1.00 40.44  ? 497  PHE A CB  1 
ATOM   2718 C  CG  . PHE A 1 507 ? 114.958 139.682 216.626 1.00 40.44  ? 497  PHE A CG  1 
ATOM   2719 C  CD1 . PHE A 1 507 ? 113.898 140.204 217.344 1.00 40.44  ? 497  PHE A CD1 1 
ATOM   2720 C  CD2 . PHE A 1 507 ? 116.243 139.886 217.095 1.00 40.44  ? 497  PHE A CD2 1 
ATOM   2721 C  CE1 . PHE A 1 507 ? 114.114 140.903 218.514 1.00 40.44  ? 497  PHE A CE1 1 
ATOM   2722 C  CE2 . PHE A 1 507 ? 116.465 140.583 218.262 1.00 40.44  ? 497  PHE A CE2 1 
ATOM   2723 C  CZ  . PHE A 1 507 ? 115.399 141.093 218.972 1.00 40.44  ? 497  PHE A CZ  1 
ATOM   2724 N  N   . ASP A 1 508 ? 112.481 136.784 213.629 1.00 32.25  ? 498  ASP A N   1 
ATOM   2725 C  CA  . ASP A 1 508 ? 112.369 136.099 212.350 1.00 32.25  ? 498  ASP A CA  1 
ATOM   2726 C  C   . ASP A 1 508 ? 112.865 137.012 211.236 1.00 32.25  ? 498  ASP A C   1 
ATOM   2727 O  O   . ASP A 1 508 ? 112.682 138.230 211.281 1.00 32.25  ? 498  ASP A O   1 
ATOM   2728 C  CB  . ASP A 1 508 ? 110.922 135.671 212.104 1.00 32.25  ? 498  ASP A CB  1 
ATOM   2729 C  CG  . ASP A 1 508 ? 110.782 134.677 210.959 1.00 32.25  ? 498  ASP A CG  1 
ATOM   2730 O  OD1 . ASP A 1 508 ? 111.449 134.837 209.918 1.00 32.25  ? 498  ASP A OD1 1 
ATOM   2731 O  OD2 . ASP A 1 508 ? 110.005 133.712 211.108 1.00 32.25  ? 498  ASP A OD2 1 
ATOM   2732 N  N   . ASP A 1 509 ? 113.493 136.413 210.227 1.00 32.24  ? 499  ASP A N   1 
ATOM   2733 C  CA  . ASP A 1 509 ? 114.132 137.162 209.151 1.00 32.24  ? 499  ASP A CA  1 
ATOM   2734 C  C   . ASP A 1 509 ? 113.827 136.538 207.796 1.00 32.24  ? 499  ASP A C   1 
ATOM   2735 O  O   . ASP A 1 509 ? 114.683 136.493 206.907 1.00 32.24  ? 499  ASP A O   1 
ATOM   2736 C  CB  . ASP A 1 509 ? 115.641 137.251 209.372 1.00 32.24  ? 499  ASP A CB  1 
ATOM   2737 C  CG  . ASP A 1 509 ? 116.311 135.890 209.383 1.00 32.24  ? 499  ASP A CG  1 
ATOM   2738 O  OD1 . ASP A 1 509 ? 115.639 134.898 209.732 1.00 32.24  ? 499  ASP A OD1 1 
ATOM   2739 O  OD2 . ASP A 1 509 ? 117.506 135.810 209.035 1.00 32.24  ? 499  ASP A OD2 1 
ATOM   2740 N  N   . ASP A 1 510 ? 112.596 136.064 207.608 1.00 28.04  ? 500  ASP A N   1 
ATOM   2741 C  CA  . ASP A 1 510 ? 112.217 135.352 206.394 1.00 28.04  ? 500  ASP A CA  1 
ATOM   2742 C  C   . ASP A 1 510 ? 111.337 136.191 205.471 1.00 28.04  ? 500  ASP A C   1 
ATOM   2743 O  O   . ASP A 1 510 ? 110.477 135.654 204.771 1.00 28.04  ? 500  ASP A O   1 
ATOM   2744 C  CB  . ASP A 1 510 ? 111.526 134.036 206.740 1.00 28.04  ? 500  ASP A CB  1 
ATOM   2745 C  CG  . ASP A 1 510 ? 112.396 133.128 207.587 1.00 28.04  ? 500  ASP A CG  1 
ATOM   2746 O  OD1 . ASP A 1 510 ? 113.628 133.116 207.382 1.00 28.04  ? 500  ASP A OD1 1 
ATOM   2747 O  OD2 . ASP A 1 510 ? 111.849 132.430 208.465 1.00 28.04  ? 500  ASP A OD2 1 
ATOM   2748 N  N   . HIS A 1 511 ? 111.535 137.505 205.462 1.00 21.85  ? 501  HIS A N   1 
ATOM   2749 C  CA  . HIS A 1 511 ? 110.890 138.346 204.464 1.00 21.85  ? 501  HIS A CA  1 
ATOM   2750 C  C   . HIS A 1 511 ? 111.496 138.070 203.094 1.00 21.85  ? 501  HIS A C   1 
ATOM   2751 O  O   . HIS A 1 511 ? 112.714 137.945 202.954 1.00 21.85  ? 501  HIS A O   1 
ATOM   2752 C  CB  . HIS A 1 511 ? 111.053 139.820 204.833 1.00 21.85  ? 501  HIS A CB  1 
ATOM   2753 C  CG  . HIS A 1 511 ? 110.040 140.723 204.202 1.00 21.85  ? 501  HIS A CG  1 
ATOM   2754 N  ND1 . HIS A 1 511 ? 109.984 140.946 202.844 1.00 21.85  ? 501  HIS A ND1 1 
ATOM   2755 C  CD2 . HIS A 1 511 ? 109.050 141.469 204.746 1.00 21.85  ? 501  HIS A CD2 1 
ATOM   2756 C  CE1 . HIS A 1 511 ? 109.001 141.785 202.577 1.00 21.85  ? 501  HIS A CE1 1 
ATOM   2757 N  NE2 . HIS A 1 511 ? 108.417 142.118 203.714 1.00 21.85  ? 501  HIS A NE2 1 
ATOM   2758 N  N   . ALA A 1 512 ? 110.641 137.964 202.077 1.00 19.33  ? 502  ALA A N   1 
ATOM   2759 C  CA  . ALA A 1 512 ? 111.127 137.616 200.748 1.00 19.33  ? 502  ALA A CA  1 
ATOM   2760 C  C   . ALA A 1 512 ? 111.812 138.776 200.043 1.00 19.33  ? 502  ALA A C   1 
ATOM   2761 O  O   . ALA A 1 512 ? 112.566 138.544 199.093 1.00 19.33  ? 502  ALA A O   1 
ATOM   2762 C  CB  . ALA A 1 512 ? 109.987 137.092 199.877 1.00 19.33  ? 502  ALA A CB  1 
ATOM   2763 N  N   . GLY A 1 513 ? 111.562 140.011 200.464 1.00 17.16  ? 503  GLY A N   1 
ATOM   2764 C  CA  . GLY A 1 513 ? 112.307 141.125 199.917 1.00 17.16  ? 503  GLY A CA  1 
ATOM   2765 C  C   . GLY A 1 513 ? 111.501 142.371 199.629 1.00 17.16  ? 503  GLY A C   1 
ATOM   2766 O  O   . GLY A 1 513 ? 110.268 142.347 199.622 1.00 17.16  ? 503  GLY A O   1 
ATOM   2767 N  N   . ILE A 1 514 ? 112.206 143.477 199.403 1.00 17.24  ? 504  ILE A N   1 
ATOM   2768 C  CA  . ILE A 1 514 ? 111.628 144.739 198.956 1.00 17.24  ? 504  ILE A CA  1 
ATOM   2769 C  C   . ILE A 1 514 ? 112.542 145.251 197.853 1.00 17.24  ? 504  ILE A C   1 
ATOM   2770 O  O   . ILE A 1 514 ? 113.713 145.549 198.107 1.00 17.24  ? 504  ILE A O   1 
ATOM   2771 C  CB  . ILE A 1 514 ? 111.506 145.771 200.085 1.00 17.24  ? 504  ILE A CB  1 
ATOM   2772 C  CG1 . ILE A 1 514 ? 110.470 145.325 201.116 1.00 17.24  ? 504  ILE A CG1 1 
ATOM   2773 C  CG2 . ILE A 1 514 ? 111.144 147.128 199.531 1.00 17.24  ? 504  ILE A CG2 1 
ATOM   2774 C  CD1 . ILE A 1 514 ? 110.385 146.230 202.320 1.00 17.24  ? 504  ILE A CD1 1 
ATOM   2775 N  N   . PHE A 1 515 ? 112.023 145.334 196.632 1.00 17.70  ? 505  PHE A N   1 
ATOM   2776 C  CA  . PHE A 1 515 ? 112.835 145.588 195.449 1.00 17.70  ? 505  PHE A CA  1 
ATOM   2777 C  C   . PHE A 1 515 ? 112.717 147.047 195.036 1.00 17.70  ? 505  PHE A C   1 
ATOM   2778 O  O   . PHE A 1 515 ? 111.624 147.522 194.712 1.00 17.70  ? 505  PHE A O   1 
ATOM   2779 C  CB  . PHE A 1 515 ? 112.432 144.666 194.298 1.00 17.70  ? 505  PHE A CB  1 
ATOM   2780 C  CG  . PHE A 1 515 ? 112.479 143.209 194.649 1.00 17.70  ? 505  PHE A CG  1 
ATOM   2781 C  CD1 . PHE A 1 515 ? 111.428 142.595 195.304 1.00 17.70  ? 505  PHE A CD1 1 
ATOM   2782 C  CD2 . PHE A 1 515 ? 113.588 142.455 194.329 1.00 17.70  ? 505  PHE A CD2 1 
ATOM   2783 C  CE1 . PHE A 1 515 ? 111.488 141.263 195.631 1.00 17.70  ? 505  PHE A CE1 1 
ATOM   2784 C  CE2 . PHE A 1 515 ? 113.649 141.123 194.652 1.00 17.70  ? 505  PHE A CE2 1 
ATOM   2785 C  CZ  . PHE A 1 515 ? 112.601 140.529 195.308 1.00 17.70  ? 505  PHE A CZ  1 
ATOM   2786 N  N   . THR A 1 516 ? 113.848 147.747 195.044 1.00 20.98  ? 506  THR A N   1 
ATOM   2787 C  CA  . THR A 1 516 ? 113.908 149.161 194.708 1.00 20.98  ? 506  THR A CA  1 
ATOM   2788 C  C   . THR A 1 516 ? 114.979 149.392 193.656 1.00 20.98  ? 506  THR A C   1 
ATOM   2789 O  O   . THR A 1 516 ? 116.002 148.705 193.628 1.00 20.98  ? 506  THR A O   1 
ATOM   2790 C  CB  . THR A 1 516 ? 114.243 150.043 195.926 1.00 20.98  ? 506  THR A CB  1 
ATOM   2791 O  OG1 . THR A 1 516 ? 115.629 149.895 196.251 1.00 20.98  ? 506  THR A OG1 1 
ATOM   2792 C  CG2 . THR A 1 516 ? 113.424 149.654 197.138 1.00 20.98  ? 506  THR A CG2 1 
ATOM   2793 N  N   . PHE A 1 517 ? 114.748 150.371 192.792 1.00 23.12  ? 507  PHE A N   1 
ATOM   2794 C  CA  . PHE A 1 517 ? 115.852 150.897 192.008 1.00 23.12  ? 507  PHE A CA  1 
ATOM   2795 C  C   . PHE A 1 517 ? 116.749 151.745 192.898 1.00 23.12  ? 507  PHE A C   1 
ATOM   2796 O  O   . PHE A 1 517 ? 116.310 152.300 193.908 1.00 23.12  ? 507  PHE A O   1 
ATOM   2797 C  CB  . PHE A 1 517 ? 115.342 151.711 190.825 1.00 23.12  ? 507  PHE A CB  1 
ATOM   2798 C  CG  . PHE A 1 517 ? 114.965 150.876 189.647 1.00 23.12  ? 507  PHE A CG  1 
ATOM   2799 C  CD1 . PHE A 1 517 ? 115.938 150.262 188.884 1.00 23.12  ? 507  PHE A CD1 1 
ATOM   2800 C  CD2 . PHE A 1 517 ? 113.640 150.693 189.308 1.00 23.12  ? 507  PHE A CD2 1 
ATOM   2801 C  CE1 . PHE A 1 517 ? 115.596 149.487 187.802 1.00 23.12  ? 507  PHE A CE1 1 
ATOM   2802 C  CE2 . PHE A 1 517 ? 113.295 149.918 188.227 1.00 23.12  ? 507  PHE A CE2 1 
ATOM   2803 C  CZ  . PHE A 1 517 ? 114.274 149.315 187.476 1.00 23.12  ? 507  PHE A CZ  1 
ATOM   2804 N  N   . GLU A 1 518 ? 118.027 151.823 192.526 1.00 31.25  ? 508  GLU A N   1 
ATOM   2805 C  CA  . GLU A 1 518 ? 118.995 152.509 193.376 1.00 31.25  ? 508  GLU A CA  1 
ATOM   2806 C  C   . GLU A 1 518 ? 118.717 154.006 193.446 1.00 31.25  ? 508  GLU A C   1 
ATOM   2807 O  O   . GLU A 1 518 ? 118.758 154.599 194.530 1.00 31.25  ? 508  GLU A O   1 
ATOM   2808 C  CB  . GLU A 1 518 ? 120.412 152.241 192.873 1.00 31.25  ? 508  GLU A CB  1 
ATOM   2809 C  CG  . GLU A 1 518 ? 121.491 152.482 193.914 1.00 31.25  ? 508  GLU A CG  1 
ATOM   2810 C  CD  . GLU A 1 518 ? 122.882 152.208 193.383 1.00 31.25  ? 508  GLU A CD  1 
ATOM   2811 O  OE1 . GLU A 1 518 ? 123.060 152.216 192.147 1.00 31.25  ? 508  GLU A OE1 1 
ATOM   2812 O  OE2 . GLU A 1 518 ? 123.798 151.980 194.201 1.00 31.25  ? 508  GLU A OE2 1 
ATOM   2813 N  N   . GLU A 1 519 ? 118.424 154.630 192.310 1.00 32.68  ? 509  GLU A N   1 
ATOM   2814 C  CA  . GLU A 1 519 ? 118.129 156.052 192.243 1.00 32.68  ? 509  GLU A CA  1 
ATOM   2815 C  C   . GLU A 1 519 ? 117.038 156.288 191.210 1.00 32.68  ? 509  GLU A C   1 
ATOM   2816 O  O   . GLU A 1 519 ? 116.914 155.517 190.252 1.00 32.68  ? 509  GLU A O   1 
ATOM   2817 C  CB  . GLU A 1 519 ? 119.383 156.865 191.886 1.00 32.68  ? 509  GLU A CB  1 
ATOM   2818 C  CG  . GLU A 1 519 ? 120.140 156.334 190.689 1.00 32.68  ? 509  GLU A CG  1 
ATOM   2819 C  CD  . GLU A 1 519 ? 121.565 156.844 190.631 1.00 32.68  ? 509  GLU A CD  1 
ATOM   2820 O  OE1 . GLU A 1 519 ? 121.786 158.028 190.961 1.00 32.68  ? 509  GLU A OE1 1 
ATOM   2821 O  OE2 . GLU A 1 519 ? 122.463 156.062 190.256 1.00 32.68  ? 509  GLU A OE2 1 
ATOM   2822 N  N   . PRO A 1 520 ? 116.226 157.337 191.381 1.00 31.02  ? 510  PRO A N   1 
ATOM   2823 C  CA  . PRO A 1 520 ? 115.108 157.553 190.449 1.00 31.02  ? 510  PRO A CA  1 
ATOM   2824 C  C   . PRO A 1 520 ? 115.519 158.037 189.068 1.00 31.02  ? 510  PRO A C   1 
ATOM   2825 O  O   . PRO A 1 520 ? 114.733 157.874 188.127 1.00 31.02  ? 510  PRO A O   1 
ATOM   2826 C  CB  . PRO A 1 520 ? 114.250 158.603 191.167 1.00 31.02  ? 510  PRO A CB  1 
ATOM   2827 C  CG  . PRO A 1 520 ? 115.192 159.294 192.083 1.00 31.02  ? 510  PRO A CG  1 
ATOM   2828 C  CD  . PRO A 1 520 ? 116.154 158.243 192.539 1.00 31.02  ? 510  PRO A CD  1 
ATOM   2829 N  N   . VAL A 1 521 ? 116.700 158.629 188.901 1.00 30.82  ? 511  VAL A N   1 
ATOM   2830 C  CA  . VAL A 1 521 ? 117.104 159.164 187.602 1.00 30.82  ? 511  VAL A CA  1 
ATOM   2831 C  C   . VAL A 1 521 ? 118.617 159.050 187.460 1.00 30.82  ? 511  VAL A C   1 
ATOM   2832 O  O   . VAL A 1 521 ? 119.365 159.355 188.394 1.00 30.82  ? 511  VAL A O   1 
ATOM   2833 C  CB  . VAL A 1 521 ? 116.620 160.620 187.420 1.00 30.82  ? 511  VAL A CB  1 
ATOM   2834 C  CG1 . VAL A 1 521 ? 117.046 161.495 188.593 1.00 30.82  ? 511  VAL A CG1 1 
ATOM   2835 C  CG2 . VAL A 1 521 ? 117.116 161.200 186.105 1.00 30.82  ? 511  VAL A CG2 1 
ATOM   2836 N  N   . THR A 1 522 ? 119.068 158.577 186.296 1.00 32.46  ? 512  THR A N   1 
ATOM   2837 C  CA  . THR A 1 522 ? 120.484 158.487 185.965 1.00 32.46  ? 512  THR A CA  1 
ATOM   2838 C  C   . THR A 1 522 ? 120.738 159.163 184.627 1.00 32.46  ? 512  THR A C   1 
ATOM   2839 O  O   . THR A 1 522 ? 119.961 158.997 183.683 1.00 32.46  ? 512  THR A O   1 
ATOM   2840 C  CB  . THR A 1 522 ? 120.977 157.032 185.880 1.00 32.46  ? 512  THR A CB  1 
ATOM   2841 O  OG1 . THR A 1 522 ? 120.504 156.437 184.666 1.00 32.46  ? 512  THR A OG1 1 
ATOM   2842 C  CG2 . THR A 1 522 ? 120.497 156.213 187.061 1.00 32.46  ? 512  THR A CG2 1 
ATOM   2843 N  N   . HIS A 1 523 ? 121.829 159.919 184.547 1.00 36.22  ? 513  HIS A N   1 
ATOM   2844 C  CA  . HIS A 1 523 ? 122.277 160.525 183.301 1.00 36.22  ? 513  HIS A CA  1 
ATOM   2845 C  C   . HIS A 1 523 ? 123.437 159.714 182.741 1.00 36.22  ? 513  HIS A C   1 
ATOM   2846 O  O   . HIS A 1 523 ? 124.416 159.457 183.447 1.00 36.22  ? 513  HIS A O   1 
ATOM   2847 C  CB  . HIS A 1 523 ? 122.705 161.978 183.512 1.00 36.22  ? 513  HIS A CB  1 
ATOM   2848 C  CG  . HIS A 1 523 ? 121.751 162.777 184.342 1.00 36.22  ? 513  HIS A CG  1 
ATOM   2849 N  ND1 . HIS A 1 523 ? 120.756 163.553 183.789 1.00 36.22  ? 513  HIS A ND1 1 
ATOM   2850 C  CD2 . HIS A 1 523 ? 121.646 162.929 185.683 1.00 36.22  ? 513  HIS A CD2 1 
ATOM   2851 C  CE1 . HIS A 1 523 ? 120.074 164.144 184.754 1.00 36.22  ? 513  HIS A CE1 1 
ATOM   2852 N  NE2 . HIS A 1 523 ? 120.595 163.782 185.913 1.00 36.22  ? 513  HIS A NE2 1 
ATOM   2853 N  N   . VAL A 1 524 ? 123.324 159.311 181.475 1.00 40.92  ? 514  VAL A N   1 
ATOM   2854 C  CA  . VAL A 1 524 ? 124.320 158.460 180.840 1.00 40.92  ? 514  VAL A CA  1 
ATOM   2855 C  C   . VAL A 1 524 ? 124.595 158.982 179.434 1.00 40.92  ? 514  VAL A C   1 
ATOM   2856 O  O   . VAL A 1 524 ? 123.800 159.723 178.854 1.00 40.92  ? 514  VAL A O   1 
ATOM   2857 C  CB  . VAL A 1 524 ? 123.860 156.982 180.808 1.00 40.92  ? 514  VAL A CB  1 
ATOM   2858 C  CG1 . VAL A 1 524 ? 122.888 156.732 179.667 1.00 40.92  ? 514  VAL A CG1 1 
ATOM   2859 C  CG2 . VAL A 1 524 ? 125.048 156.037 180.763 1.00 40.92  ? 514  VAL A CG2 1 
ATOM   2860 N  N   . SER A 1 525 ? 125.759 158.619 178.903 1.00 52.52  ? 515  SER A N   1 
ATOM   2861 C  CA  . SER A 1 525 ? 126.142 158.922 177.532 1.00 52.52  ? 515  SER A CA  1 
ATOM   2862 C  C   . SER A 1 525 ? 126.071 157.660 176.678 1.00 52.52  ? 515  SER A C   1 
ATOM   2863 O  O   . SER A 1 525 ? 125.975 156.544 177.192 1.00 52.52  ? 515  SER A O   1 
ATOM   2864 C  CB  . SER A 1 525 ? 127.550 159.517 177.482 1.00 52.52  ? 515  SER A CB  1 
ATOM   2865 O  OG  . SER A 1 525 ? 128.444 158.777 178.293 1.00 52.52  ? 515  SER A OG  1 
ATOM   2866 N  N   . GLU A 1 526 ? 126.117 157.847 175.356 1.00 58.61  ? 516  GLU A N   1 
ATOM   2867 C  CA  . GLU A 1 526 ? 126.014 156.689 174.475 1.00 58.61  ? 516  GLU A CA  1 
ATOM   2868 C  C   . GLU A 1 526 ? 127.303 155.882 174.427 1.00 58.61  ? 516  GLU A C   1 
ATOM   2869 O  O   . GLU A 1 526 ? 127.287 154.751 173.932 1.00 58.61  ? 516  GLU A O   1 
ATOM   2870 C  CB  . GLU A 1 526 ? 125.650 157.084 173.037 1.00 58.61  ? 516  GLU A CB  1 
ATOM   2871 C  CG  . GLU A 1 526 ? 126.305 158.335 172.465 1.00 58.61  ? 516  GLU A CG  1 
ATOM   2872 C  CD  . GLU A 1 526 ? 125.662 159.615 172.916 1.00 58.61  ? 516  GLU A CD  1 
ATOM   2873 O  OE1 . GLU A 1 526 ? 125.778 159.920 174.112 1.00 58.61  ? 516  GLU A OE1 1 
ATOM   2874 O  OE2 . GLU A 1 526 ? 125.051 160.312 172.082 1.00 58.61  ? 516  GLU A OE2 1 
ATOM   2875 N  N   . SER A 1 527 ? 128.413 156.439 174.915 1.00 62.92  ? 517  SER A N   1 
ATOM   2876 C  CA  . SER A 1 527 ? 129.690 155.738 174.878 1.00 62.92  ? 517  SER A CA  1 
ATOM   2877 C  C   . SER A 1 527 ? 129.731 154.547 175.824 1.00 62.92  ? 517  SER A C   1 
ATOM   2878 O  O   . SER A 1 527 ? 130.633 153.712 175.706 1.00 62.92  ? 517  SER A O   1 
ATOM   2879 C  CB  . SER A 1 527 ? 130.826 156.705 175.211 1.00 62.92  ? 517  SER A CB  1 
ATOM   2880 O  OG  . SER A 1 527 ? 130.576 157.385 176.428 1.00 62.92  ? 517  SER A OG  1 
ATOM   2881 N  N   . ILE A 1 528 ? 128.786 154.455 176.763 1.00 58.67  ? 518  ILE A N   1 
ATOM   2882 C  CA  . ILE A 1 528 ? 128.787 153.343 177.707 1.00 58.67  ? 518  ILE A CA  1 
ATOM   2883 C  C   . ILE A 1 528 ? 128.438 152.032 177.009 1.00 58.67  ? 518  ILE A C   1 
ATOM   2884 O  O   . ILE A 1 528 ? 128.865 150.957 177.449 1.00 58.67  ? 518  ILE A O   1 
ATOM   2885 C  CB  . ILE A 1 528 ? 127.840 153.646 178.886 1.00 58.67  ? 518  ILE A CB  1 
ATOM   2886 C  CG1 . ILE A 1 528 ? 128.129 152.712 180.062 1.00 58.67  ? 518  ILE A CG1 1 
ATOM   2887 C  CG2 . ILE A 1 528 ? 126.383 153.533 178.468 1.00 58.67  ? 518  ILE A CG2 1 
ATOM   2888 C  CD1 . ILE A 1 528 ? 127.562 153.197 181.375 1.00 58.67  ? 518  ILE A CD1 1 
ATOM   2889 N  N   . GLY A 1 529 ? 127.685 152.088 175.911 1.00 57.62  ? 519  GLY A N   1 
ATOM   2890 C  CA  . GLY A 1 529 ? 127.264 150.882 175.227 1.00 57.62  ? 519  GLY A CA  1 
ATOM   2891 C  C   . GLY A 1 529 ? 126.293 150.065 176.053 1.00 57.62  ? 519  GLY A C   1 
ATOM   2892 O  O   . GLY A 1 529 ? 125.155 150.485 176.282 1.00 57.62  ? 519  GLY A O   1 
ATOM   2893 N  N   . ILE A 1 530 ? 126.730 148.894 176.502 1.00 50.48  ? 520  ILE A N   1 
ATOM   2894 C  CA  . ILE A 1 530 ? 125.925 148.062 177.389 1.00 50.48  ? 520  ILE A CA  1 
ATOM   2895 C  C   . ILE A 1 530 ? 126.069 148.594 178.809 1.00 50.48  ? 520  ILE A C   1 
ATOM   2896 O  O   . ILE A 1 530 ? 127.183 148.708 179.330 1.00 50.48  ? 520  ILE A O   1 
ATOM   2897 C  CB  . ILE A 1 530 ? 126.349 146.590 177.300 1.00 50.48  ? 520  ILE A CB  1 
ATOM   2898 C  CG1 . ILE A 1 530 ? 125.978 146.017 175.927 1.00 50.48  ? 520  ILE A CG1 1 
ATOM   2899 C  CG2 . ILE A 1 530 ? 125.735 145.789 178.445 1.00 50.48  ? 520  ILE A CG2 1 
ATOM   2900 C  CD1 . ILE A 1 530 ? 125.748 144.517 175.903 1.00 50.48  ? 520  ILE A CD1 1 
ATOM   2901 N  N   . MET A 1 531 ? 124.942 148.914 179.438 1.00 45.82  ? 521  MET A N   1 
ATOM   2902 C  CA  . MET A 1 531 ? 124.913 149.485 180.774 1.00 45.82  ? 521  MET A CA  1 
ATOM   2903 C  C   . MET A 1 531 ? 124.190 148.542 181.727 1.00 45.82  ? 521  MET A C   1 
ATOM   2904 O  O   . MET A 1 531 ? 123.278 147.806 181.332 1.00 45.82  ? 521  MET A O   1 
ATOM   2905 C  CB  . MET A 1 531 ? 124.235 150.865 180.775 1.00 45.82  ? 521  MET A CB  1 
ATOM   2906 C  CG  . MET A 1 531 ? 122.744 150.839 180.480 1.00 45.82  ? 521  MET A CG  1 
ATOM   2907 S  SD  . MET A 1 531 ? 122.004 152.481 180.423 1.00 45.82  ? 521  MET A SD  1 
ATOM   2908 C  CE  . MET A 1 531 ? 122.070 152.945 182.151 1.00 45.82  ? 521  MET A CE  1 
ATOM   2909 N  N   . GLU A 1 532 ? 124.622 148.566 182.984 1.00 38.32  ? 522  GLU A N   1 
ATOM   2910 C  CA  . GLU A 1 532 ? 124.077 147.721 184.036 1.00 38.32  ? 522  GLU A CA  1 
ATOM   2911 C  C   . GLU A 1 532 ? 123.326 148.588 185.036 1.00 38.32  ? 522  GLU A C   1 
ATOM   2912 O  O   . GLU A 1 532 ? 123.863 149.590 185.518 1.00 38.32  ? 522  GLU A O   1 
ATOM   2913 C  CB  . GLU A 1 532 ? 125.188 146.946 184.750 1.00 38.32  ? 522  GLU A CB  1 
ATOM   2914 C  CG  . GLU A 1 532 ? 126.087 146.097 183.853 1.00 38.32  ? 522  GLU A CG  1 
ATOM   2915 C  CD  . GLU A 1 532 ? 125.377 144.905 183.233 1.00 38.32  ? 522  GLU A CD  1 
ATOM   2916 O  OE1 . GLU A 1 532 ? 124.592 145.095 182.282 1.00 38.32  ? 522  GLU A OE1 1 
ATOM   2917 O  OE2 . GLU A 1 532 ? 125.609 143.771 183.699 1.00 38.32  ? 522  GLU A OE2 1 
ATOM   2918 N  N   . VAL A 1 533 ? 122.092 148.201 185.344 1.00 28.57  ? 523  VAL A N   1 
ATOM   2919 C  CA  . VAL A 1 533 ? 121.270 148.890 186.332 1.00 28.57  ? 523  VAL A CA  1 
ATOM   2920 C  C   . VAL A 1 533 ? 120.979 147.919 187.467 1.00 28.57  ? 523  VAL A C   1 
ATOM   2921 O  O   . VAL A 1 533 ? 120.406 146.849 187.238 1.00 28.57  ? 523  VAL A O   1 
ATOM   2922 C  CB  . VAL A 1 533 ? 119.965 149.417 185.721 1.00 28.57  ? 523  VAL A CB  1 
ATOM   2923 C  CG1 . VAL A 1 533 ? 119.098 150.018 186.803 1.00 28.57  ? 523  VAL A CG1 1 
ATOM   2924 C  CG2 . VAL A 1 533 ? 120.262 150.438 184.641 1.00 28.57  ? 523  VAL A CG2 1 
ATOM   2925 N  N   . LYS A 1 534 ? 121.369 148.287 188.681 1.00 26.16  ? 524  LYS A N   1 
ATOM   2926 C  CA  . LYS A 1 534 ? 121.159 147.417 189.827 1.00 26.16  ? 524  LYS A CA  1 
ATOM   2927 C  C   . LYS A 1 534 ? 119.715 147.496 190.306 1.00 26.16  ? 524  LYS A C   1 
ATOM   2928 O  O   . LYS A 1 534 ? 119.053 148.529 190.178 1.00 26.16  ? 524  LYS A O   1 
ATOM   2929 C  CB  . LYS A 1 534 ? 122.110 147.793 190.963 1.00 26.16  ? 524  LYS A CB  1 
ATOM   2930 C  CG  . LYS A 1 534 ? 123.580 147.607 190.622 1.00 26.16  ? 524  LYS A CG  1 
ATOM   2931 C  CD  . LYS A 1 534 ? 124.455 147.700 191.859 1.00 26.16  ? 524  LYS A CD  1 
ATOM   2932 C  CE  . LYS A 1 534 ? 124.289 149.039 192.554 1.00 26.16  ? 524  LYS A CE  1 
ATOM   2933 N  NZ  . LYS A 1 534 ? 125.090 149.117 193.805 1.00 26.16  ? 524  LYS A NZ  1 
ATOM   2934 N  N   . VAL A 1 535 ? 119.225 146.387 190.857 1.00 21.07  ? 525  VAL A N   1 
ATOM   2935 C  CA  . VAL A 1 535 ? 117.888 146.313 191.443 1.00 21.07  ? 525  VAL A CA  1 
ATOM   2936 C  C   . VAL A 1 535 ? 118.070 145.791 192.864 1.00 21.07  ? 525  VAL A C   1 
ATOM   2937 O  O   . VAL A 1 535 ? 118.226 144.583 193.074 1.00 21.07  ? 525  VAL A O   1 
ATOM   2938 C  CB  . VAL A 1 535 ? 116.940 145.418 190.638 1.00 21.07  ? 525  VAL A CB  1 
ATOM   2939 C  CG1 . VAL A 1 535 ? 115.613 145.270 191.355 1.00 21.07  ? 525  VAL A CG1 1 
ATOM   2940 C  CG2 . VAL A 1 535 ? 116.729 145.986 189.250 1.00 21.07  ? 525  VAL A CG2 1 
ATOM   2941 N  N   . LEU A 1 536 ? 118.066 146.695 193.840 1.00 19.71  ? 526  LEU A N   1 
ATOM   2942 C  CA  . LEU A 1 536 ? 118.344 146.313 195.216 1.00 19.71  ? 526  LEU A CA  1 
ATOM   2943 C  C   . LEU A 1 536 ? 117.179 145.535 195.810 1.00 19.71  ? 526  LEU A C   1 
ATOM   2944 O  O   . LEU A 1 536 ? 116.011 145.852 195.571 1.00 19.71  ? 526  LEU A O   1 
ATOM   2945 C  CB  . LEU A 1 536 ? 118.621 147.555 196.059 1.00 19.71  ? 526  LEU A CB  1 
ATOM   2946 C  CG  . LEU A 1 536 ? 119.876 148.355 195.719 1.00 19.71  ? 526  LEU A CG  1 
ATOM   2947 C  CD1 . LEU A 1 536 ? 119.947 149.608 196.569 1.00 19.71  ? 526  LEU A CD1 1 
ATOM   2948 C  CD2 . LEU A 1 536 ? 121.116 147.508 195.918 1.00 19.71  ? 526  LEU A CD2 1 
ATOM   2949 N  N   . ARG A 1 537 ? 117.507 144.516 196.600 1.00 15.33  ? 527  ARG A N   1 
ATOM   2950 C  CA  . ARG A 1 537 ? 116.533 143.694 197.314 1.00 15.33  ? 527  ARG A CA  1 
ATOM   2951 C  C   . ARG A 1 537 ? 116.847 143.814 198.801 1.00 15.33  ? 527  ARG A C   1 
ATOM   2952 O  O   . ARG A 1 537 ? 117.782 143.180 199.296 1.00 15.33  ? 527  ARG A O   1 
ATOM   2953 C  CB  . ARG A 1 537 ? 116.595 142.246 196.837 1.00 15.33  ? 527  ARG A CB  1 
ATOM   2954 C  CG  . ARG A 1 537 ? 115.810 141.243 197.666 1.00 15.33  ? 527  ARG A CG  1 
ATOM   2955 C  CD  . ARG A 1 537 ? 115.971 139.848 197.085 1.00 15.33  ? 527  ARG A CD  1 
ATOM   2956 N  NE  . ARG A 1 537 ? 115.189 138.841 197.791 1.00 15.33  ? 527  ARG A NE  1 
ATOM   2957 C  CZ  . ARG A 1 537 ? 115.284 137.538 197.569 1.00 15.33  ? 527  ARG A CZ  1 
ATOM   2958 N  NH1 . ARG A 1 537 ? 116.120 137.050 196.670 1.00 15.33  ? 527  ARG A NH1 1 
ATOM   2959 N  NH2 . ARG A 1 537 ? 114.516 136.704 198.262 1.00 15.33  ? 527  ARG A NH2 1 
ATOM   2960 N  N   . THR A 1 538 ? 116.077 144.627 199.514 1.00 17.63  ? 528  THR A N   1 
ATOM   2961 C  CA  . THR A 1 538 ? 116.335 144.910 200.917 1.00 17.63  ? 528  THR A CA  1 
ATOM   2962 C  C   . THR A 1 538 ? 115.296 144.236 201.802 1.00 17.63  ? 528  THR A C   1 
ATOM   2963 O  O   . THR A 1 538 ? 114.366 143.580 201.329 1.00 17.63  ? 528  THR A O   1 
ATOM   2964 C  CB  . THR A 1 538 ? 116.346 146.421 201.176 1.00 17.63  ? 528  THR A CB  1 
ATOM   2965 O  OG1 . THR A 1 538 ? 115.031 146.950 200.977 1.00 17.63  ? 528  THR A OG1 1 
ATOM   2966 C  CG2 . THR A 1 538 ? 117.305 147.113 200.227 1.00 17.63  ? 528  THR A CG2 1 
ATOM   2967 N  N   . SER A 1 539 ? 115.498 144.381 203.112 1.00 18.59  ? 529  SER A N   1 
ATOM   2968 C  CA  . SER A 1 539 ? 114.609 143.964 204.195 1.00 18.59  ? 529  SER A CA  1 
ATOM   2969 C  C   . SER A 1 539 ? 114.430 142.453 204.301 1.00 18.59  ? 529  SER A C   1 
ATOM   2970 O  O   . SER A 1 539 ? 113.700 141.998 205.189 1.00 18.59  ? 529  SER A O   1 
ATOM   2971 C  CB  . SER A 1 539 ? 113.223 144.617 204.096 1.00 18.59  ? 529  SER A CB  1 
ATOM   2972 O  OG  . SER A 1 539 ? 112.465 144.374 205.267 1.00 18.59  ? 529  SER A OG  1 
ATOM   2973 N  N   . GLY A 1 540 ? 115.062 141.664 203.445 1.00 20.92  ? 530  GLY A N   1 
ATOM   2974 C  CA  . GLY A 1 540 ? 114.962 140.222 203.549 1.00 20.92  ? 530  GLY A CA  1 
ATOM   2975 C  C   . GLY A 1 540 ? 115.584 139.563 202.342 1.00 20.92  ? 530  GLY A C   1 
ATOM   2976 O  O   . GLY A 1 540 ? 115.879 140.205 201.331 1.00 20.92  ? 530  GLY A O   1 
ATOM   2977 N  N   . ALA A 1 541 ? 115.791 138.253 202.468 1.00 20.03  ? 531  ALA A N   1 
ATOM   2978 C  CA  . ALA A 1 541 ? 116.427 137.498 201.394 1.00 20.03  ? 531  ALA A CA  1 
ATOM   2979 C  C   . ALA A 1 541 ? 115.787 136.155 201.076 1.00 20.03  ? 531  ALA A C   1 
ATOM   2980 O  O   . ALA A 1 541 ? 116.115 135.589 200.029 1.00 20.03  ? 531  ALA A O   1 
ATOM   2981 C  CB  . ALA A 1 541 ? 117.905 137.273 201.714 1.00 20.03  ? 531  ALA A CB  1 
ATOM   2982 N  N   . ARG A 1 542 ? 114.896 135.623 201.913 1.00 22.83  ? 532  ARG A N   1 
ATOM   2983 C  CA  . ARG A 1 542 ? 114.399 134.263 201.743 1.00 22.83  ? 532  ARG A CA  1 
ATOM   2984 C  C   . ARG A 1 542 ? 113.604 134.108 200.449 1.00 22.83  ? 532  ARG A C   1 
ATOM   2985 O  O   . ARG A 1 542 ? 113.072 135.069 199.891 1.00 22.83  ? 532  ARG A O   1 
ATOM   2986 C  CB  . ARG A 1 542 ? 113.519 133.858 202.923 1.00 22.83  ? 532  ARG A CB  1 
ATOM   2987 C  CG  . ARG A 1 542 ? 114.278 133.361 204.132 1.00 22.83  ? 532  ARG A CG  1 
ATOM   2988 C  CD  . ARG A 1 542 ? 115.279 132.287 203.759 1.00 22.83  ? 532  ARG A CD  1 
ATOM   2989 N  NE  . ARG A 1 542 ? 116.648 132.785 203.776 1.00 22.83  ? 532  ARG A NE  1 
ATOM   2990 C  CZ  . ARG A 1 542 ? 117.348 133.026 204.876 1.00 22.83  ? 532  ARG A CZ  1 
ATOM   2991 N  NH1 . ARG A 1 542 ? 116.847 132.800 206.080 1.00 22.83  ? 532  ARG A NH1 1 
ATOM   2992 N  NH2 . ARG A 1 542 ? 118.586 133.500 204.766 1.00 22.83  ? 532  ARG A NH2 1 
ATOM   2993 N  N   . GLY A 1 543 ? 113.546 132.871 199.968 1.00 25.31  ? 533  GLY A N   1 
ATOM   2994 C  CA  . GLY A 1 543 ? 112.767 132.544 198.795 1.00 25.31  ? 533  GLY A CA  1 
ATOM   2995 C  C   . GLY A 1 543 ? 113.446 132.943 197.500 1.00 25.31  ? 533  GLY A C   1 
ATOM   2996 O  O   . GLY A 1 543 ? 114.499 133.580 197.465 1.00 25.31  ? 533  GLY A O   1 
ATOM   2997 N  N   . ASN A 1 544 ? 112.805 132.549 196.405 1.00 27.08  ? 534  ASN A N   1 
ATOM   2998 C  CA  . ASN A 1 544 ? 113.225 132.880 195.051 1.00 27.08  ? 534  ASN A CA  1 
ATOM   2999 C  C   . ASN A 1 544 ? 112.105 133.685 194.415 1.00 27.08  ? 534  ASN A C   1 
ATOM   3000 O  O   . ASN A 1 544 ? 110.937 133.296 194.503 1.00 27.08  ? 534  ASN A O   1 
ATOM   3001 C  CB  . ASN A 1 544 ? 113.516 131.605 194.258 1.00 27.08  ? 534  ASN A CB  1 
ATOM   3002 C  CG  . ASN A 1 544 ? 114.182 131.865 192.923 1.00 27.08  ? 534  ASN A CG  1 
ATOM   3003 O  OD1 . ASN A 1 544 ? 114.041 132.931 192.334 1.00 27.08  ? 534  ASN A OD1 1 
ATOM   3004 N  ND2 . ASN A 1 544 ? 114.917 130.873 192.436 1.00 27.08  ? 534  ASN A ND2 1 
ATOM   3005 N  N   . VAL A 1 545 ? 112.448 134.808 193.788 1.00 25.83  ? 535  VAL A N   1 
ATOM   3006 C  CA  . VAL A 1 545 ? 111.439 135.771 193.360 1.00 25.83  ? 535  VAL A CA  1 
ATOM   3007 C  C   . VAL A 1 545 ? 111.732 136.215 191.934 1.00 25.83  ? 535  VAL A C   1 
ATOM   3008 O  O   . VAL A 1 545 ? 112.860 136.610 191.628 1.00 25.83  ? 535  VAL A O   1 
ATOM   3009 C  CB  . VAL A 1 545 ? 111.398 136.987 194.305 1.00 25.83  ? 535  VAL A CB  1 
ATOM   3010 C  CG1 . VAL A 1 545 ? 110.723 138.161 193.636 1.00 25.83  ? 535  VAL A CG1 1 
ATOM   3011 C  CG2 . VAL A 1 545 ? 110.704 136.631 195.604 1.00 25.83  ? 535  VAL A CG2 1 
ATOM   3012 N  N   . ILE A 1 546 ? 110.719 136.179 191.068 1.00 41.22  ? 536  ILE A N   1 
ATOM   3013 C  CA  . ILE A 1 546 ? 110.831 136.746 189.729 1.00 41.22  ? 536  ILE A CA  1 
ATOM   3014 C  C   . ILE A 1 546 ? 110.269 138.158 189.737 1.00 41.22  ? 536  ILE A C   1 
ATOM   3015 O  O   . ILE A 1 546 ? 109.144 138.389 190.192 1.00 41.22  ? 536  ILE A O   1 
ATOM   3016 C  CB  . ILE A 1 546 ? 110.118 135.890 188.668 1.00 41.22  ? 536  ILE A CB  1 
ATOM   3017 C  CG1 . ILE A 1 546 ? 110.184 134.405 188.984 1.00 41.22  ? 536  ILE A CG1 1 
ATOM   3018 C  CG2 . ILE A 1 546 ? 110.703 136.134 187.306 1.00 41.22  ? 536  ILE A CG2 1 
ATOM   3019 C  CD1 . ILE A 1 546 ? 109.188 133.632 188.164 1.00 41.22  ? 536  ILE A CD1 1 
ATOM   3020 N  N   . VAL A 1 547 ? 111.057 139.098 189.229 1.00 29.06  ? 537  VAL A N   1 
ATOM   3021 C  CA  . VAL A 1 547 ? 110.652 140.487 189.039 1.00 29.06  ? 537  VAL A CA  1 
ATOM   3022 C  C   . VAL A 1 547 ? 110.618 140.763 187.541 1.00 29.06  ? 537  VAL A C   1 
ATOM   3023 O  O   . VAL A 1 547 ? 111.679 140.806 186.903 1.00 29.06  ? 537  VAL A O   1 
ATOM   3024 C  CB  . VAL A 1 547 ? 111.609 141.451 189.755 1.00 29.06  ? 537  VAL A CB  1 
ATOM   3025 C  CG1 . VAL A 1 547 ? 111.185 142.885 189.530 1.00 29.06  ? 537  VAL A CG1 1 
ATOM   3026 C  CG2 . VAL A 1 547 ? 111.676 141.135 191.231 1.00 29.06  ? 537  VAL A CG2 1 
ATOM   3027 N  N   . PRO A 1 548 ? 109.447 140.895 186.926 1.00 28.19  ? 538  PRO A N   1 
ATOM   3028 C  CA  . PRO A 1 548 ? 109.407 141.292 185.515 1.00 28.19  ? 538  PRO A CA  1 
ATOM   3029 C  C   . PRO A 1 548 ? 109.899 142.718 185.343 1.00 28.19  ? 538  PRO A C   1 
ATOM   3030 O  O   . PRO A 1 548 ? 109.703 143.566 186.214 1.00 28.19  ? 538  PRO A O   1 
ATOM   3031 C  CB  . PRO A 1 548 ? 107.925 141.159 185.149 1.00 28.19  ? 538  PRO A CB  1 
ATOM   3032 C  CG  . PRO A 1 548 ? 107.203 141.227 186.447 1.00 28.19  ? 538  PRO A CG  1 
ATOM   3033 C  CD  . PRO A 1 548 ? 108.107 140.613 187.463 1.00 28.19  ? 538  PRO A CD  1 
ATOM   3034 N  N   . TYR A 1 549 ? 110.552 142.979 184.213 1.00 29.29  ? 539  TYR A N   1 
ATOM   3035 C  CA  . TYR A 1 549 ? 111.058 144.307 183.904 1.00 29.29  ? 539  TYR A CA  1 
ATOM   3036 C  C   . TYR A 1 549 ? 110.907 144.571 182.414 1.00 29.29  ? 539  TYR A C   1 
ATOM   3037 O  O   . TYR A 1 549 ? 110.931 143.646 181.596 1.00 29.29  ? 539  TYR A O   1 
ATOM   3038 C  CB  . TYR A 1 549 ? 112.526 144.469 184.335 1.00 29.29  ? 539  TYR A CB  1 
ATOM   3039 C  CG  . TYR A 1 549 ? 113.536 143.766 183.452 1.00 29.29  ? 539  TYR A CG  1 
ATOM   3040 C  CD1 . TYR A 1 549 ? 113.890 142.447 183.692 1.00 29.29  ? 539  TYR A CD1 1 
ATOM   3041 C  CD2 . TYR A 1 549 ? 114.161 144.428 182.403 1.00 29.29  ? 539  TYR A CD2 1 
ATOM   3042 C  CE1 . TYR A 1 549 ? 114.818 141.800 182.900 1.00 29.29  ? 539  TYR A CE1 1 
ATOM   3043 C  CE2 . TYR A 1 549 ? 115.084 143.786 181.602 1.00 29.29  ? 539  TYR A CE2 1 
ATOM   3044 C  CZ  . TYR A 1 549 ? 115.410 142.474 181.858 1.00 29.29  ? 539  TYR A CZ  1 
ATOM   3045 O  OH  . TYR A 1 549 ? 116.334 141.832 181.068 1.00 29.29  ? 539  TYR A OH  1 
ATOM   3046 N  N   . LYS A 1 550 ? 110.771 145.850 182.071 1.00 30.52  ? 540  LYS A N   1 
ATOM   3047 C  CA  . LYS A 1 550 ? 110.617 146.255 180.683 1.00 30.52  ? 540  LYS A CA  1 
ATOM   3048 C  C   . LYS A 1 550 ? 111.123 147.680 180.522 1.00 30.52  ? 540  LYS A C   1 
ATOM   3049 O  O   . LYS A 1 550 ? 111.354 148.395 181.500 1.00 30.52  ? 540  LYS A O   1 
ATOM   3050 C  CB  . LYS A 1 550 ? 109.162 146.137 180.222 1.00 30.52  ? 540  LYS A CB  1 
ATOM   3051 C  CG  . LYS A 1 550 ? 108.297 147.333 180.567 1.00 30.52  ? 540  LYS A CG  1 
ATOM   3052 C  CD  . LYS A 1 550 ? 106.889 147.150 180.035 1.00 30.52  ? 540  LYS A CD  1 
ATOM   3053 C  CE  . LYS A 1 550 ? 106.000 148.320 180.409 1.00 30.52  ? 540  LYS A CE  1 
ATOM   3054 N  NZ  . LYS A 1 550 ? 104.623 148.147 179.875 1.00 30.52  ? 540  LYS A NZ  1 
ATOM   3055 N  N   . THR A 1 551 ? 111.309 148.083 179.267 1.00 31.46  ? 541  THR A N   1 
ATOM   3056 C  CA  . THR A 1 551 ? 111.765 149.422 178.919 1.00 31.46  ? 541  THR A CA  1 
ATOM   3057 C  C   . THR A 1 551 ? 110.665 150.144 178.157 1.00 31.46  ? 541  THR A C   1 
ATOM   3058 O  O   . THR A 1 551 ? 110.079 149.583 177.226 1.00 31.46  ? 541  THR A O   1 
ATOM   3059 C  CB  . THR A 1 551 ? 113.036 149.378 178.072 1.00 31.46  ? 541  THR A CB  1 
ATOM   3060 O  OG1 . THR A 1 551 ? 112.714 148.918 176.755 1.00 31.46  ? 541  THR A OG1 1 
ATOM   3061 C  CG2 . THR A 1 551 ? 114.056 148.444 178.690 1.00 31.46  ? 541  THR A CG2 1 
ATOM   3062 N  N   . ILE A 1 552 ? 110.396 151.386 178.549 1.00 35.51  ? 542  ILE A N   1 
ATOM   3063 C  CA  . ILE A 1 552 ? 109.358 152.210 177.947 1.00 35.51  ? 542  ILE A CA  1 
ATOM   3064 C  C   . ILE A 1 552 ? 110.029 153.345 177.189 1.00 35.51  ? 542  ILE A C   1 
ATOM   3065 O  O   . ILE A 1 552 ? 110.910 154.029 177.727 1.00 35.51  ? 542  ILE A O   1 
ATOM   3066 C  CB  . ILE A 1 552 ? 108.389 152.756 179.009 1.00 35.51  ? 542  ILE A CB  1 
ATOM   3067 C  CG1 . ILE A 1 552 ? 107.946 151.634 179.947 1.00 35.51  ? 542  ILE A CG1 1 
ATOM   3068 C  CG2 . ILE A 1 552 ? 107.187 153.406 178.348 1.00 35.51  ? 542  ILE A CG2 1 
ATOM   3069 C  CD1 . ILE A 1 552 ? 106.963 152.077 181.001 1.00 35.51  ? 542  ILE A CD1 1 
ATOM   3070 N  N   . GLU A 1 553 ? 109.618 153.540 175.940 1.00 42.65  ? 543  GLU A N   1 
ATOM   3071 C  CA  . GLU A 1 553 ? 110.170 154.601 175.110 1.00 42.65  ? 543  GLU A CA  1 
ATOM   3072 C  C   . GLU A 1 553 ? 109.590 155.938 175.549 1.00 42.65  ? 543  GLU A C   1 
ATOM   3073 O  O   . GLU A 1 553 ? 108.369 156.127 175.534 1.00 42.65  ? 543  GLU A O   1 
ATOM   3074 C  CB  . GLU A 1 553 ? 109.860 154.342 173.638 1.00 42.65  ? 543  GLU A CB  1 
ATOM   3075 C  CG  . GLU A 1 553 ? 110.123 152.918 173.189 1.00 42.65  ? 543  GLU A CG  1 
ATOM   3076 C  CD  . GLU A 1 553 ? 109.642 152.658 171.777 1.00 42.65  ? 543  GLU A CD  1 
ATOM   3077 O  OE1 . GLU A 1 553 ? 109.563 153.623 170.990 1.00 42.65  ? 543  GLU A OE1 1 
ATOM   3078 O  OE2 . GLU A 1 553 ? 109.343 151.490 171.454 1.00 42.65  ? 543  GLU A OE2 1 
ATOM   3079 N  N   . GLY A 1 554 ? 110.460 156.862 175.939 1.00 40.41  ? 544  GLY A N   1 
ATOM   3080 C  CA  . GLY A 1 554 ? 110.029 158.205 176.262 1.00 40.41  ? 544  GLY A CA  1 
ATOM   3081 C  C   . GLY A 1 554 ? 110.269 159.139 175.098 1.00 40.41  ? 544  GLY A C   1 
ATOM   3082 O  O   . GLY A 1 554 ? 109.702 158.951 174.018 1.00 40.41  ? 544  GLY A O   1 
ATOM   3083 N  N   . THR A 1 555 ? 111.104 160.157 175.307 1.00 42.27  ? 545  THR A N   1 
ATOM   3084 C  CA  . THR A 1 555 ? 111.534 160.994 174.193 1.00 42.27  ? 545  THR A CA  1 
ATOM   3085 C  C   . THR A 1 555 ? 112.409 160.200 173.228 1.00 42.27  ? 545  THR A C   1 
ATOM   3086 O  O   . THR A 1 555 ? 112.288 160.343 172.005 1.00 42.27  ? 545  THR A O   1 
ATOM   3087 C  CB  . THR A 1 555 ? 112.272 162.224 174.723 1.00 42.27  ? 545  THR A CB  1 
ATOM   3088 O  OG1 . THR A 1 555 ? 111.365 163.027 175.487 1.00 42.27  ? 545  THR A OG1 1 
ATOM   3089 C  CG2 . THR A 1 555 ? 112.815 163.065 173.584 1.00 42.27  ? 545  THR A CG2 1 
ATOM   3090 N  N   . ALA A 1 556 ? 113.270 159.335 173.759 1.00 44.53  ? 546  ALA A N   1 
ATOM   3091 C  CA  . ALA A 1 556 ? 114.147 158.503 172.942 1.00 44.53  ? 546  ALA A CA  1 
ATOM   3092 C  C   . ALA A 1 556 ? 113.339 157.365 172.335 1.00 44.53  ? 546  ALA A C   1 
ATOM   3093 O  O   . ALA A 1 556 ? 112.972 156.417 173.035 1.00 44.53  ? 546  ALA A O   1 
ATOM   3094 C  CB  . ALA A 1 556 ? 115.297 157.957 173.781 1.00 44.53  ? 546  ALA A CB  1 
ATOM   3095 N  N   . ARG A 1 557 ? 113.061 157.453 171.037 1.00 50.04  ? 547  ARG A N   1 
ATOM   3096 C  CA  . ARG A 1 557 ? 112.359 156.377 170.352 1.00 50.04  ? 547  ARG A CA  1 
ATOM   3097 C  C   . ARG A 1 557 ? 113.250 155.145 170.263 1.00 50.04  ? 547  ARG A C   1 
ATOM   3098 O  O   . ARG A 1 557 ? 114.418 155.235 169.876 1.00 50.04  ? 547  ARG A O   1 
ATOM   3099 C  CB  . ARG A 1 557 ? 111.924 156.825 168.958 1.00 50.04  ? 547  ARG A CB  1 
ATOM   3100 C  CG  . ARG A 1 557 ? 111.065 158.074 168.959 1.00 50.04  ? 547  ARG A CG  1 
ATOM   3101 C  CD  . ARG A 1 557 ? 109.741 157.812 169.658 1.00 50.04  ? 547  ARG A CD  1 
ATOM   3102 N  NE  . ARG A 1 557 ? 109.226 158.999 170.328 1.00 50.04  ? 547  ARG A NE  1 
ATOM   3103 C  CZ  . ARG A 1 557 ? 108.214 158.994 171.184 1.00 50.04  ? 547  ARG A CZ  1 
ATOM   3104 N  NH1 . ARG A 1 557 ? 107.582 157.875 171.501 1.00 50.04  ? 547  ARG A NH1 1 
ATOM   3105 N  NH2 . ARG A 1 557 ? 107.826 160.139 171.738 1.00 50.04  ? 547  ARG A NH2 1 
ATOM   3106 N  N   . GLY A 1 558 ? 112.696 153.993 170.629 1.00 51.03  ? 548  GLY A N   1 
ATOM   3107 C  CA  . GLY A 1 558 ? 113.476 152.775 170.673 1.00 51.03  ? 548  GLY A CA  1 
ATOM   3108 C  C   . GLY A 1 558 ? 113.030 151.712 169.694 1.00 51.03  ? 548  GLY A C   1 
ATOM   3109 O  O   . GLY A 1 558 ? 111.945 151.141 169.828 1.00 51.03  ? 548  GLY A O   1 
ATOM   3110 N  N   . GLY A 1 559 ? 113.863 151.452 168.692 1.00 59.37  ? 549  GLY A N   1 
ATOM   3111 C  CA  . GLY A 1 559 ? 113.648 150.355 167.772 1.00 59.37  ? 549  GLY A CA  1 
ATOM   3112 C  C   . GLY A 1 559 ? 114.968 149.720 167.394 1.00 59.37  ? 549  GLY A C   1 
ATOM   3113 O  O   . GLY A 1 559 ? 115.123 149.183 166.294 1.00 59.37  ? 549  GLY A O   1 
ATOM   3114 N  N   . GLY A 1 560 ? 115.930 149.779 168.312 1.00 61.21  ? 550  GLY A N   1 
ATOM   3115 C  CA  . GLY A 1 560 ? 117.296 149.420 168.013 1.00 61.21  ? 550  GLY A CA  1 
ATOM   3116 C  C   . GLY A 1 560 ? 118.126 150.539 167.428 1.00 61.21  ? 550  GLY A C   1 
ATOM   3117 O  O   . GLY A 1 560 ? 119.313 150.327 167.149 1.00 61.21  ? 550  GLY A O   1 
ATOM   3118 N  N   . GLU A 1 561 ? 117.543 151.721 167.232 1.00 69.23  ? 551  GLU A N   1 
ATOM   3119 C  CA  . GLU A 1 561 ? 118.270 152.866 166.700 1.00 69.23  ? 551  GLU A CA  1 
ATOM   3120 C  C   . GLU A 1 561 ? 118.832 153.766 167.792 1.00 69.23  ? 551  GLU A C   1 
ATOM   3121 O  O   . GLU A 1 561 ? 119.855 154.424 167.574 1.00 69.23  ? 551  GLU A O   1 
ATOM   3122 C  CB  . GLU A 1 561 ? 117.360 153.676 165.768 1.00 69.23  ? 551  GLU A CB  1 
ATOM   3123 C  CG  . GLU A 1 561 ? 116.184 154.350 166.457 1.00 69.23  ? 551  GLU A CG  1 
ATOM   3124 C  CD  . GLU A 1 561 ? 115.070 154.704 165.496 1.00 69.23  ? 551  GLU A CD  1 
ATOM   3125 O  OE1 . GLU A 1 561 ? 114.665 153.826 164.706 1.00 69.23  ? 551  GLU A OE1 1 
ATOM   3126 O  OE2 . GLU A 1 561 ? 114.598 155.859 165.532 1.00 69.23  ? 551  GLU A OE2 1 
ATOM   3127 N  N   . ASP A 1 562 ? 118.188 153.814 168.957 1.00 58.57  ? 552  ASP A N   1 
ATOM   3128 C  CA  . ASP A 1 562 ? 118.686 154.565 170.100 1.00 58.57  ? 552  ASP A CA  1 
ATOM   3129 C  C   . ASP A 1 562 ? 118.890 153.708 171.337 1.00 58.57  ? 552  ASP A C   1 
ATOM   3130 O  O   . ASP A 1 562 ? 119.824 153.964 172.098 1.00 58.57  ? 552  ASP A O   1 
ATOM   3131 C  CB  . ASP A 1 562 ? 117.732 155.719 170.440 1.00 58.57  ? 552  ASP A CB  1 
ATOM   3132 C  CG  . ASP A 1 562 ? 118.446 156.895 171.070 1.00 58.57  ? 552  ASP A CG  1 
ATOM   3133 O  OD1 . ASP A 1 562 ? 119.024 156.727 172.163 1.00 58.57  ? 552  ASP A OD1 1 
ATOM   3134 O  OD2 . ASP A 1 562 ? 118.435 157.989 170.468 1.00 58.57  ? 552  ASP A OD2 1 
ATOM   3135 N  N   . PHE A 1 563 ? 118.044 152.704 171.555 1.00 51.38  ? 553  PHE A N   1 
ATOM   3136 C  CA  . PHE A 1 563 ? 118.272 151.697 172.579 1.00 51.38  ? 553  PHE A CA  1 
ATOM   3137 C  C   . PHE A 1 563 ? 117.545 150.425 172.172 1.00 51.38  ? 553  PHE A C   1 
ATOM   3138 O  O   . PHE A 1 563 ? 116.526 150.471 171.478 1.00 51.38  ? 553  PHE A O   1 
ATOM   3139 C  CB  . PHE A 1 563 ? 117.828 152.185 173.970 1.00 51.38  ? 553  PHE A CB  1 
ATOM   3140 C  CG  . PHE A 1 563 ? 116.335 152.203 174.180 1.00 51.38  ? 553  PHE A CG  1 
ATOM   3141 C  CD1 . PHE A 1 563 ? 115.601 153.338 173.885 1.00 51.38  ? 553  PHE A CD1 1 
ATOM   3142 C  CD2 . PHE A 1 563 ? 115.674 151.113 174.727 1.00 51.38  ? 553  PHE A CD2 1 
ATOM   3143 C  CE1 . PHE A 1 563 ? 114.237 153.372 174.092 1.00 51.38  ? 553  PHE A CE1 1 
ATOM   3144 C  CE2 . PHE A 1 563 ? 114.310 151.141 174.930 1.00 51.38  ? 553  PHE A CE2 1 
ATOM   3145 C  CZ  . PHE A 1 563 ? 113.592 152.273 174.614 1.00 51.38  ? 553  PHE A CZ  1 
ATOM   3146 N  N   . GLU A 1 564 ? 118.079 149.289 172.607 1.00 55.14  ? 554  GLU A N   1 
ATOM   3147 C  CA  . GLU A 1 564 ? 117.466 148.003 172.307 1.00 55.14  ? 554  GLU A CA  1 
ATOM   3148 C  C   . GLU A 1 564 ? 116.338 147.725 173.291 1.00 55.14  ? 554  GLU A C   1 
ATOM   3149 O  O   . GLU A 1 564 ? 116.521 147.842 174.506 1.00 55.14  ? 554  GLU A O   1 
ATOM   3150 C  CB  . GLU A 1 564 ? 118.507 146.887 172.363 1.00 55.14  ? 554  GLU A CB  1 
ATOM   3151 C  CG  . GLU A 1 564 ? 119.529 146.932 171.241 1.00 55.14  ? 554  GLU A CG  1 
ATOM   3152 C  CD  . GLU A 1 564 ? 119.278 145.877 170.182 1.00 55.14  ? 554  GLU A CD  1 
ATOM   3153 O  OE1 . GLU A 1 564 ? 118.103 145.503 169.981 1.00 55.14  ? 554  GLU A OE1 1 
ATOM   3154 O  OE2 . GLU A 1 564 ? 120.255 145.421 169.551 1.00 55.14  ? 554  GLU A OE2 1 
ATOM   3155 N  N   . ASP A 1 565 ? 115.170 147.368 172.765 1.00 50.46  ? 555  ASP A N   1 
ATOM   3156 C  CA  . ASP A 1 565 ? 114.014 147.067 173.604 1.00 50.46  ? 555  ASP A CA  1 
ATOM   3157 C  C   . ASP A 1 565 ? 114.226 145.731 174.302 1.00 50.46  ? 555  ASP A C   1 
ATOM   3158 O  O   . ASP A 1 565 ? 114.249 144.680 173.654 1.00 50.46  ? 555  ASP A O   1 
ATOM   3159 C  CB  . ASP A 1 565 ? 112.743 147.044 172.762 1.00 50.46  ? 555  ASP A CB  1 
ATOM   3160 C  CG  . ASP A 1 565 ? 112.393 148.402 172.200 1.00 50.46  ? 555  ASP A CG  1 
ATOM   3161 O  OD1 . ASP A 1 565 ? 112.210 149.346 172.995 1.00 50.46  ? 555  ASP A OD1 1 
ATOM   3162 O  OD2 . ASP A 1 565 ? 112.302 148.525 170.962 1.00 50.46  ? 555  ASP A OD2 1 
ATOM   3163 N  N   . THR A 1 566 ? 114.380 145.764 175.623 1.00 43.99  ? 556  THR A N   1 
ATOM   3164 C  CA  . THR A 1 566 ? 114.530 144.560 176.429 1.00 43.99  ? 556  THR A CA  1 
ATOM   3165 C  C   . THR A 1 566 ? 113.326 144.417 177.346 1.00 43.99  ? 556  THR A C   1 
ATOM   3166 O  O   . THR A 1 566 ? 112.984 145.350 178.077 1.00 43.99  ? 556  THR A O   1 
ATOM   3167 C  CB  . THR A 1 566 ? 115.815 144.594 177.263 1.00 43.99  ? 556  THR A CB  1 
ATOM   3168 O  OG1 . THR A 1 566 ? 115.555 145.233 178.518 1.00 43.99  ? 556  THR A OG1 1 
ATOM   3169 C  CG2 . THR A 1 566 ? 116.915 145.343 176.534 1.00 43.99  ? 556  THR A CG2 1 
ATOM   3170 N  N   . CYS A 1 567 ? 112.691 143.250 177.304 1.00 36.54  ? 557  CYS A N   1 
ATOM   3171 C  CA  . CYS A 1 567 ? 111.593 142.912 178.201 1.00 36.54  ? 557  CYS A CA  1 
ATOM   3172 C  C   . CYS A 1 567 ? 111.865 141.524 178.755 1.00 36.54  ? 557  CYS A C   1 
ATOM   3173 O  O   . CYS A 1 567 ? 111.836 140.542 178.007 1.00 36.54  ? 557  CYS A O   1 
ATOM   3174 C  CB  . CYS A 1 567 ? 110.247 142.951 177.473 1.00 36.54  ? 557  CYS A CB  1 
ATOM   3175 S  SG  . CYS A 1 567 ? 109.879 144.524 176.665 1.00 36.54  ? 557  CYS A SG  1 
ATOM   3176 N  N   . GLY A 1 568 ? 112.129 141.439 180.058 1.00 27.91  ? 558  GLY A N   1 
ATOM   3177 C  CA  . GLY A 1 568 ? 112.591 140.199 180.647 1.00 27.91  ? 558  GLY A CA  1 
ATOM   3178 C  C   . GLY A 1 568 ? 112.018 139.983 182.032 1.00 27.91  ? 558  GLY A C   1 
ATOM   3179 O  O   . GLY A 1 568 ? 111.170 140.742 182.500 1.00 27.91  ? 558  GLY A O   1 
ATOM   3180 N  N   . GLU A 1 569 ? 112.493 138.919 182.675 1.00 28.74  ? 559  GLU A N   1 
ATOM   3181 C  CA  . GLU A 1 569 ? 112.053 138.539 184.015 1.00 28.74  ? 559  GLU A CA  1 
ATOM   3182 C  C   . GLU A 1 569 ? 113.286 138.192 184.846 1.00 28.74  ? 559  GLU A C   1 
ATOM   3183 O  O   . GLU A 1 569 ? 113.835 137.094 184.712 1.00 28.74  ? 559  GLU A O   1 
ATOM   3184 C  CB  . GLU A 1 569 ? 111.076 137.368 183.957 1.00 28.74  ? 559  GLU A CB  1 
ATOM   3185 C  CG  . GLU A 1 569 ? 109.806 137.641 183.164 1.00 28.74  ? 559  GLU A CG  1 
ATOM   3186 C  CD  . GLU A 1 569 ? 108.613 136.850 183.669 1.00 28.74  ? 559  GLU A CD  1 
ATOM   3187 O  OE1 . GLU A 1 569 ? 108.782 136.057 184.618 1.00 28.74  ? 559  GLU A OE1 1 
ATOM   3188 O  OE2 . GLU A 1 569 ? 107.505 137.026 183.120 1.00 28.74  ? 559  GLU A OE2 1 
ATOM   3189 N  N   . LEU A 1 570 ? 113.725 139.123 185.691 1.00 26.43  ? 560  LEU A N   1 
ATOM   3190 C  CA  . LEU A 1 570 ? 114.844 138.859 186.585 1.00 26.43  ? 560  LEU A CA  1 
ATOM   3191 C  C   . LEU A 1 570 ? 114.465 137.796 187.603 1.00 26.43  ? 560  LEU A C   1 
ATOM   3192 O  O   . LEU A 1 570 ? 113.342 137.776 188.105 1.00 26.43  ? 560  LEU A O   1 
ATOM   3193 C  CB  . LEU A 1 570 ? 115.250 140.129 187.324 1.00 26.43  ? 560  LEU A CB  1 
ATOM   3194 C  CG  . LEU A 1 570 ? 115.814 141.313 186.552 1.00 26.43  ? 560  LEU A CG  1 
ATOM   3195 C  CD1 . LEU A 1 570 ? 116.171 142.401 187.539 1.00 26.43  ? 560  LEU A CD1 1 
ATOM   3196 C  CD2 . LEU A 1 570 ? 117.022 140.899 185.741 1.00 26.43  ? 560  LEU A CD2 1 
ATOM   3197 N  N   . GLU A 1 571 ? 115.409 136.919 187.929 1.00 25.35  ? 561  GLU A N   1 
ATOM   3198 C  CA  . GLU A 1 571 ? 115.192 135.899 188.946 1.00 25.35  ? 561  GLU A CA  1 
ATOM   3199 C  C   . GLU A 1 571 ? 116.187 136.104 190.079 1.00 25.35  ? 561  GLU A C   1 
ATOM   3200 O  O   . GLU A 1 571 ? 117.401 136.066 189.857 1.00 25.35  ? 561  GLU A O   1 
ATOM   3201 C  CB  . GLU A 1 571 ? 115.317 134.494 188.358 1.00 25.35  ? 561  GLU A CB  1 
ATOM   3202 C  CG  . GLU A 1 571 ? 115.135 133.396 189.384 1.00 25.35  ? 561  GLU A CG  1 
ATOM   3203 C  CD  . GLU A 1 571 ? 114.325 132.229 188.866 1.00 25.35  ? 561  GLU A CD  1 
ATOM   3204 O  OE1 . GLU A 1 571 ? 113.490 132.440 187.963 1.00 25.35  ? 561  GLU A OE1 1 
ATOM   3205 O  OE2 . GLU A 1 571 ? 114.513 131.102 189.369 1.00 25.35  ? 561  GLU A OE2 1 
ATOM   3206 N  N   . PHE A 1 572 ? 115.670 136.317 191.286 1.00 23.87  ? 562  PHE A N   1 
ATOM   3207 C  CA  . PHE A 1 572 ? 116.473 136.515 192.483 1.00 23.87  ? 562  PHE A CA  1 
ATOM   3208 C  C   . PHE A 1 572 ? 116.472 135.213 193.270 1.00 23.87  ? 562  PHE A C   1 
ATOM   3209 O  O   . PHE A 1 572 ? 115.426 134.803 193.791 1.00 23.87  ? 562  PHE A O   1 
ATOM   3210 C  CB  . PHE A 1 572 ? 115.915 137.640 193.355 1.00 23.87  ? 562  PHE A CB  1 
ATOM   3211 C  CG  . PHE A 1 572 ? 116.171 139.029 192.834 1.00 23.87  ? 562  PHE A CG  1 
ATOM   3212 C  CD1 . PHE A 1 572 ? 115.765 139.410 191.568 1.00 23.87  ? 562  PHE A CD1 1 
ATOM   3213 C  CD2 . PHE A 1 572 ? 116.797 139.963 193.633 1.00 23.87  ? 562  PHE A CD2 1 
ATOM   3214 C  CE1 . PHE A 1 572 ? 115.993 140.687 191.110 1.00 23.87  ? 562  PHE A CE1 1 
ATOM   3215 C  CE2 . PHE A 1 572 ? 117.026 141.238 193.179 1.00 23.87  ? 562  PHE A CE2 1 
ATOM   3216 C  CZ  . PHE A 1 572 ? 116.622 141.601 191.918 1.00 23.87  ? 562  PHE A CZ  1 
ATOM   3217 N  N   . GLN A 1 573 ? 117.640 134.584 193.374 1.00 22.68  ? 563  GLN A N   1 
ATOM   3218 C  CA  . GLN A 1 573 ? 117.775 133.325 194.089 1.00 22.68  ? 563  GLN A CA  1 
ATOM   3219 C  C   . GLN A 1 573 ? 117.717 133.563 195.596 1.00 22.68  ? 563  GLN A C   1 
ATOM   3220 O  O   . GLN A 1 573 ? 117.494 134.678 196.075 1.00 22.68  ? 563  GLN A O   1 
ATOM   3221 C  CB  . GLN A 1 573 ? 119.084 132.638 193.708 1.00 22.68  ? 563  GLN A CB  1 
ATOM   3222 C  CG  . GLN A 1 573 ? 119.277 132.422 192.220 1.00 22.68  ? 563  GLN A CG  1 
ATOM   3223 C  CD  . GLN A 1 573 ? 118.582 131.176 191.721 1.00 22.68  ? 563  GLN A CD  1 
ATOM   3224 O  OE1 . GLN A 1 573 ? 118.076 130.377 192.508 1.00 22.68  ? 563  GLN A OE1 1 
ATOM   3225 N  NE2 . GLN A 1 573 ? 118.556 131.000 190.406 1.00 22.68  ? 563  GLN A NE2 1 
ATOM   3226 N  N   . ASN A 1 574 ? 117.921 132.490 196.354 1.00 21.79  ? 564  ASN A N   1 
ATOM   3227 C  CA  . ASN A 1 574 ? 117.963 132.595 197.804 1.00 21.79  ? 564  ASN A CA  1 
ATOM   3228 C  C   . ASN A 1 574 ? 119.213 133.356 198.229 1.00 21.79  ? 564  ASN A C   1 
ATOM   3229 O  O   . ASN A 1 574 ? 120.321 133.045 197.781 1.00 21.79  ? 564  ASN A O   1 
ATOM   3230 C  CB  . ASN A 1 574 ? 117.939 131.201 198.431 1.00 21.79  ? 564  ASN A CB  1 
ATOM   3231 C  CG  . ASN A 1 574 ? 117.621 131.224 199.915 1.00 21.79  ? 564  ASN A CG  1 
ATOM   3232 O  OD1 . ASN A 1 574 ? 118.188 132.002 200.679 1.00 21.79  ? 564  ASN A OD1 1 
ATOM   3233 N  ND2 . ASN A 1 574 ? 116.705 130.358 200.330 1.00 21.79  ? 564  ASN A ND2 1 
ATOM   3234 N  N   . ASP A 1 575 ? 119.021 134.358 199.090 1.00 24.28  ? 565  ASP A N   1 
ATOM   3235 C  CA  . ASP A 1 575 ? 120.102 135.180 199.643 1.00 24.28  ? 565  ASP A CA  1 
ATOM   3236 C  C   . ASP A 1 575 ? 120.927 135.858 198.551 1.00 24.28  ? 565  ASP A C   1 
ATOM   3237 O  O   . ASP A 1 575 ? 122.146 135.989 198.662 1.00 24.28  ? 565  ASP A O   1 
ATOM   3238 C  CB  . ASP A 1 575 ? 120.998 134.362 200.574 1.00 24.28  ? 565  ASP A CB  1 
ATOM   3239 C  CG  . ASP A 1 575 ? 120.496 134.351 202.003 1.00 24.28  ? 565  ASP A CG  1 
ATOM   3240 O  OD1 . ASP A 1 575 ? 120.459 135.431 202.629 1.00 24.28  ? 565  ASP A OD1 1 
ATOM   3241 O  OD2 . ASP A 1 575 ? 120.134 133.265 202.500 1.00 24.28  ? 565  ASP A OD2 1 
ATOM   3242 N  N   . GLU A 1 576 ? 120.260 136.296 197.488 1.00 24.28  ? 566  GLU A N   1 
ATOM   3243 C  CA  . GLU A 1 576 ? 120.887 137.090 196.437 1.00 24.28  ? 566  GLU A CA  1 
ATOM   3244 C  C   . GLU A 1 576 ? 120.273 138.482 196.487 1.00 24.28  ? 566  GLU A C   1 
ATOM   3245 O  O   . GLU A 1 576 ? 119.062 138.638 196.302 1.00 24.28  ? 566  GLU A O   1 
ATOM   3246 C  CB  . GLU A 1 576 ? 120.700 136.449 195.065 1.00 24.28  ? 566  GLU A CB  1 
ATOM   3247 C  CG  . GLU A 1 576 ? 121.248 137.290 193.928 1.00 24.28  ? 566  GLU A CG  1 
ATOM   3248 C  CD  . GLU A 1 576 ? 121.307 136.534 192.619 1.00 24.28  ? 566  GLU A CD  1 
ATOM   3249 O  OE1 . GLU A 1 576 ? 120.621 135.499 192.497 1.00 24.28  ? 566  GLU A OE1 1 
ATOM   3250 O  OE2 . GLU A 1 576 ? 122.051 136.967 191.717 1.00 24.28  ? 566  GLU A OE2 1 
ATOM   3251 N  N   . ILE A 1 577 ? 121.104 139.488 196.735 1.00 21.35  ? 567  ILE A N   1 
ATOM   3252 C  CA  . ILE A 1 577 ? 120.609 140.826 197.038 1.00 21.35  ? 567  ILE A CA  1 
ATOM   3253 C  C   . ILE A 1 577 ? 120.524 141.696 195.790 1.00 21.35  ? 567  ILE A C   1 
ATOM   3254 O  O   . ILE A 1 577 ? 119.519 142.371 195.560 1.00 21.35  ? 567  ILE A O   1 
ATOM   3255 C  CB  . ILE A 1 577 ? 121.491 141.469 198.129 1.00 21.35  ? 567  ILE A CB  1 
ATOM   3256 C  CG1 . ILE A 1 577 ? 121.254 140.768 199.466 1.00 21.35  ? 567  ILE A CG1 1 
ATOM   3257 C  CG2 . ILE A 1 577 ? 121.203 142.953 198.258 1.00 21.35  ? 567  ILE A CG2 1 
ATOM   3258 C  CD1 . ILE A 1 577 ? 122.005 141.379 200.622 1.00 21.35  ? 567  ILE A CD1 1 
ATOM   3259 N  N   . VAL A 1 578 ? 121.553 141.701 194.949 1.00 21.67  ? 568  VAL A N   1 
ATOM   3260 C  CA  . VAL A 1 578 ? 121.635 142.628 193.827 1.00 21.67  ? 568  VAL A CA  1 
ATOM   3261 C  C   . VAL A 1 578 ? 121.621 141.843 192.524 1.00 21.67  ? 568  VAL A C   1 
ATOM   3262 O  O   . VAL A 1 578 ? 122.368 140.871 192.370 1.00 21.67  ? 568  VAL A O   1 
ATOM   3263 C  CB  . VAL A 1 578 ? 122.891 143.513 193.915 1.00 21.67  ? 568  VAL A CB  1 
ATOM   3264 C  CG1 . VAL A 1 578 ? 122.947 144.471 192.743 1.00 21.67  ? 568  VAL A CG1 1 
ATOM   3265 C  CG2 . VAL A 1 578 ? 122.907 144.276 195.226 1.00 21.67  ? 568  VAL A CG2 1 
ATOM   3266 N  N   . LYS A 1 579 ? 120.768 142.267 191.593 1.00 24.81  ? 569  LYS A N   1 
ATOM   3267 C  CA  . LYS A 1 579 ? 120.735 141.745 190.236 1.00 24.81  ? 569  LYS A CA  1 
ATOM   3268 C  C   . LYS A 1 579 ? 120.816 142.919 189.269 1.00 24.81  ? 569  LYS A C   1 
ATOM   3269 O  O   . LYS A 1 579 ? 120.347 144.021 189.567 1.00 24.81  ? 569  LYS A O   1 
ATOM   3270 C  CB  . LYS A 1 579 ? 119.461 140.917 189.990 1.00 24.81  ? 569  LYS A CB  1 
ATOM   3271 C  CG  . LYS A 1 579 ? 119.359 140.256 188.623 1.00 24.81  ? 569  LYS A CG  1 
ATOM   3272 C  CD  . LYS A 1 579 ? 120.472 139.251 188.399 1.00 24.81  ? 569  LYS A CD  1 
ATOM   3273 C  CE  . LYS A 1 579 ? 120.240 137.988 189.206 1.00 24.81  ? 569  LYS A CE  1 
ATOM   3274 N  NZ  . LYS A 1 579 ? 119.146 137.162 188.632 1.00 24.81  ? 569  LYS A NZ  1 
ATOM   3275 N  N   . THR A 1 580 ? 121.412 142.681 188.105 1.00 28.39  ? 570  THR A N   1 
ATOM   3276 C  CA  . THR A 1 580 ? 121.688 143.738 187.144 1.00 28.39  ? 570  THR A CA  1 
ATOM   3277 C  C   . THR A 1 580 ? 120.857 143.550 185.883 1.00 28.39  ? 570  THR A C   1 
ATOM   3278 O  O   . THR A 1 580 ? 120.753 142.442 185.350 1.00 28.39  ? 570  THR A O   1 
ATOM   3279 C  CB  . THR A 1 580 ? 123.173 143.777 186.775 1.00 28.39  ? 570  THR A CB  1 
ATOM   3280 O  OG1 . THR A 1 580 ? 123.656 142.441 186.590 1.00 28.39  ? 570  THR A OG1 1 
ATOM   3281 C  CG2 . THR A 1 580 ? 123.976 144.449 187.875 1.00 28.39  ? 570  THR A CG2 1 
ATOM   3282 N  N   . ILE A 1 581 ? 120.267 144.647 185.420 1.00 29.28  ? 571  ILE A N   1 
ATOM   3283 C  CA  . ILE A 1 581 ? 119.561 144.713 184.147 1.00 29.28  ? 571  ILE A CA  1 
ATOM   3284 C  C   . ILE A 1 581 ? 120.514 145.284 183.110 1.00 29.28  ? 571  ILE A C   1 
ATOM   3285 O  O   . ILE A 1 581 ? 121.111 146.346 183.327 1.00 29.28  ? 571  ILE A O   1 
ATOM   3286 C  CB  . ILE A 1 581 ? 118.295 145.577 184.261 1.00 29.28  ? 571  ILE A CB  1 
ATOM   3287 C  CG1 . ILE A 1 581 ? 117.282 144.919 185.194 1.00 29.28  ? 571  ILE A CG1 1 
ATOM   3288 C  CG2 . ILE A 1 581 ? 117.694 145.833 182.892 1.00 29.28  ? 571  ILE A CG2 1 
ATOM   3289 C  CD1 . ILE A 1 581 ? 116.042 145.741 185.430 1.00 29.28  ? 571  ILE A CD1 1 
ATOM   3290 N  N   . SER A 1 582 ? 120.668 144.580 181.992 1.00 39.13  ? 572  SER A N   1 
ATOM   3291 C  CA  . SER A 1 582 ? 121.574 144.985 180.925 1.00 39.13  ? 572  SER A CA  1 
ATOM   3292 C  C   . SER A 1 582 ? 120.778 145.674 179.826 1.00 39.13  ? 572  SER A C   1 
ATOM   3293 O  O   . SER A 1 582 ? 119.846 145.086 179.267 1.00 39.13  ? 572  SER A O   1 
ATOM   3294 C  CB  . SER A 1 582 ? 122.326 143.778 180.368 1.00 39.13  ? 572  SER A CB  1 
ATOM   3295 O  OG  . SER A 1 582 ? 123.090 143.146 181.381 1.00 39.13  ? 572  SER A OG  1 
ATOM   3296 N  N   . VAL A 1 583 ? 121.145 146.917 179.519 1.00 46.31  ? 573  VAL A N   1 
ATOM   3297 C  CA  . VAL A 1 583 ? 120.472 147.707 178.494 1.00 46.31  ? 573  VAL A CA  1 
ATOM   3298 C  C   . VAL A 1 583 ? 121.505 148.169 177.479 1.00 46.31  ? 573  VAL A C   1 
ATOM   3299 O  O   . VAL A 1 583 ? 122.576 148.657 177.851 1.00 46.31  ? 573  VAL A O   1 
ATOM   3300 C  CB  . VAL A 1 583 ? 119.733 148.921 179.094 1.00 46.31  ? 573  VAL A CB  1 
ATOM   3301 C  CG1 . VAL A 1 583 ? 118.826 149.558 178.054 1.00 46.31  ? 573  VAL A CG1 1 
ATOM   3302 C  CG2 . VAL A 1 583 ? 118.942 148.515 180.317 1.00 46.31  ? 573  VAL A CG2 1 
ATOM   3303 N  N   . LYS A 1 584 ? 121.183 148.032 176.197 1.00 54.90  ? 574  LYS A N   1 
ATOM   3304 C  CA  . LYS A 1 584 ? 122.079 148.450 175.128 1.00 54.90  ? 574  LYS A CA  1 
ATOM   3305 C  C   . LYS A 1 584 ? 121.688 149.839 174.644 1.00 54.90  ? 574  LYS A C   1 
ATOM   3306 O  O   . LYS A 1 584 ? 120.522 150.083 174.319 1.00 54.90  ? 574  LYS A O   1 
ATOM   3307 C  CB  . LYS A 1 584 ? 122.048 147.456 173.966 1.00 54.90  ? 574  LYS A CB  1 
ATOM   3308 C  CG  . LYS A 1 584 ? 123.074 147.751 172.885 1.00 54.90  ? 574  LYS A CG  1 
ATOM   3309 C  CD  . LYS A 1 584 ? 123.322 146.538 172.006 1.00 54.90  ? 574  LYS A CD  1 
ATOM   3310 C  CE  . LYS A 1 584 ? 124.612 146.688 171.217 1.00 54.90  ? 574  LYS A CE  1 
ATOM   3311 N  NZ  . LYS A 1 584 ? 124.880 148.107 170.848 1.00 54.90  ? 574  LYS A NZ  1 
ATOM   3312 N  N   . VAL A 1 585 ? 122.662 150.743 174.601 1.00 57.66  ? 575  VAL A N   1 
ATOM   3313 C  CA  . VAL A 1 585 ? 122.464 152.112 174.137 1.00 57.66  ? 575  VAL A CA  1 
ATOM   3314 C  C   . VAL A 1 585 ? 123.267 152.292 172.856 1.00 57.66  ? 575  VAL A C   1 
ATOM   3315 O  O   . VAL A 1 585 ? 124.479 152.041 172.835 1.00 57.66  ? 575  VAL A O   1 
ATOM   3316 C  CB  . VAL A 1 585 ? 122.881 153.139 175.200 1.00 57.66  ? 575  VAL A CB  1 
ATOM   3317 C  CG1 . VAL A 1 585 ? 122.624 154.549 174.704 1.00 57.66  ? 575  VAL A CG1 1 
ATOM   3318 C  CG2 . VAL A 1 585 ? 122.140 152.885 176.500 1.00 57.66  ? 575  VAL A CG2 1 
ATOM   3319 N  N   . ILE A 1 586 ? 122.597 152.726 171.795 1.00 59.68  ? 576  ILE A N   1 
ATOM   3320 C  CA  . ILE A 1 586 ? 123.231 152.867 170.488 1.00 59.68  ? 576  ILE A CA  1 
ATOM   3321 C  C   . ILE A 1 586 ? 124.003 154.178 170.445 1.00 59.68  ? 576  ILE A C   1 
ATOM   3322 O  O   . ILE A 1 586 ? 123.476 155.236 170.808 1.00 59.68  ? 576  ILE A O   1 
ATOM   3323 C  CB  . ILE A 1 586 ? 122.182 152.799 169.367 1.00 59.68  ? 576  ILE A CB  1 
ATOM   3324 C  CG1 . ILE A 1 586 ? 121.453 151.452 169.395 1.00 59.68  ? 576  ILE A CG1 1 
ATOM   3325 C  CG2 . ILE A 1 586 ? 122.830 153.021 168.010 1.00 59.68  ? 576  ILE A CG2 1 
ATOM   3326 C  CD1 . ILE A 1 586 ? 122.368 150.248 169.527 1.00 59.68  ? 576  ILE A CD1 1 
ATOM   3327 N  N   . ASP A 1 587 ? 125.257 154.112 169.998 1.00 65.84  ? 577  ASP A N   1 
ATOM   3328 C  CA  . ASP A 1 587 ? 126.142 155.275 169.970 1.00 65.84  ? 577  ASP A CA  1 
ATOM   3329 C  C   . ASP A 1 587 ? 125.922 156.044 168.673 1.00 65.84  ? 577  ASP A C   1 
ATOM   3330 O  O   . ASP A 1 587 ? 126.436 155.668 167.617 1.00 65.84  ? 577  ASP A O   1 
ATOM   3331 C  CB  . ASP A 1 587 ? 127.597 154.851 170.122 1.00 65.84  ? 577  ASP A CB  1 
ATOM   3332 C  CG  . ASP A 1 587 ? 128.501 156.006 170.504 1.00 65.84  ? 577  ASP A CG  1 
ATOM   3333 O  OD1 . ASP A 1 587 ? 128.721 156.899 169.660 1.00 65.84  ? 577  ASP A OD1 1 
ATOM   3334 O  OD2 . ASP A 1 587 ? 128.988 156.025 171.652 1.00 65.84  ? 577  ASP A OD2 1 
ATOM   3335 N  N   . ASP A 1 588 ? 125.158 157.131 168.756 1.00 70.01  ? 578  ASP A N   1 
ATOM   3336 C  CA  . ASP A 1 588 ? 124.936 158.016 167.622 1.00 70.01  ? 578  ASP A CA  1 
ATOM   3337 C  C   . ASP A 1 588 ? 125.988 159.114 167.521 1.00 70.01  ? 578  ASP A C   1 
ATOM   3338 O  O   . ASP A 1 588 ? 125.996 159.845 166.525 1.00 70.01  ? 578  ASP A O   1 
ATOM   3339 C  CB  . ASP A 1 588 ? 123.540 158.644 167.721 1.00 70.01  ? 578  ASP A CB  1 
ATOM   3340 C  CG  . ASP A 1 588 ? 122.883 158.835 166.367 1.00 70.01  ? 578  ASP A CG  1 
ATOM   3341 O  OD1 . ASP A 1 588 ? 123.599 159.047 165.368 1.00 70.01  ? 578  ASP A OD1 1 
ATOM   3342 O  OD2 . ASP A 1 588 ? 121.638 158.771 166.305 1.00 70.01  ? 578  ASP A OD2 1 
ATOM   3343 N  N   . GLU A 1 589 ? 126.855 159.240 168.536 1.00 66.41  ? 579  GLU A N   1 
ATOM   3344 C  CA  . GLU A 1 589 ? 127.963 160.210 168.611 1.00 66.41  ? 579  GLU A CA  1 
ATOM   3345 C  C   . GLU A 1 589 ? 127.541 161.631 168.220 1.00 66.41  ? 579  GLU A C   1 
ATOM   3346 O  O   . GLU A 1 589 ? 128.308 162.397 167.632 1.00 66.41  ? 579  GLU A O   1 
ATOM   3347 C  CB  . GLU A 1 589 ? 129.186 159.727 167.810 1.00 66.41  ? 579  GLU A CB  1 
ATOM   3348 C  CG  . GLU A 1 589 ? 129.104 159.714 166.284 1.00 66.41  ? 579  GLU A CG  1 
ATOM   3349 C  CD  . GLU A 1 589 ? 130.193 158.868 165.655 1.00 66.41  ? 579  GLU A CD  1 
ATOM   3350 O  OE1 . GLU A 1 589 ? 131.337 158.905 166.153 1.00 66.41  ? 579  GLU A OE1 1 
ATOM   3351 O  OE2 . GLU A 1 589 ? 129.904 158.163 164.665 1.00 66.41  ? 579  GLU A OE2 1 
ATOM   3352 N  N   . GLU A 1 590 ? 126.319 162.000 168.594 1.00 62.31  ? 580  GLU A N   1 
ATOM   3353 C  CA  . GLU A 1 590 ? 125.837 163.355 168.370 1.00 62.31  ? 580  GLU A CA  1 
ATOM   3354 C  C   . GLU A 1 590 ? 126.515 164.322 169.337 1.00 62.31  ? 580  GLU A C   1 
ATOM   3355 O  O   . GLU A 1 590 ? 126.894 163.955 170.452 1.00 62.31  ? 580  GLU A O   1 
ATOM   3356 C  CB  . GLU A 1 590 ? 124.314 163.401 168.527 1.00 62.31  ? 580  GLU A CB  1 
ATOM   3357 C  CG  . GLU A 1 590 ? 123.655 164.739 168.206 1.00 62.31  ? 580  GLU A CG  1 
ATOM   3358 C  CD  . GLU A 1 590 ? 124.097 165.309 166.872 1.00 62.31  ? 580  GLU A CD  1 
ATOM   3359 O  OE1 . GLU A 1 590 ? 123.558 164.879 165.832 1.00 62.31  ? 580  GLU A OE1 1 
ATOM   3360 O  OE2 . GLU A 1 590 ? 124.981 166.192 166.865 1.00 62.31  ? 580  GLU A OE2 1 
ATOM   3361 N  N   . TYR A 1 591 ? 126.683 165.570 168.887 1.00 56.69  ? 581  TYR A N   1 
ATOM   3362 C  CA  . TYR A 1 591 ? 127.369 166.575 169.696 1.00 56.69  ? 581  TYR A CA  1 
ATOM   3363 C  C   . TYR A 1 591 ? 126.589 166.904 170.963 1.00 56.69  ? 581  TYR A C   1 
ATOM   3364 O  O   . TYR A 1 591 ? 127.186 167.153 172.016 1.00 56.69  ? 581  TYR A O   1 
ATOM   3365 C  CB  . TYR A 1 591 ? 127.601 167.840 168.870 1.00 56.69  ? 581  TYR A CB  1 
ATOM   3366 C  CG  . TYR A 1 591 ? 128.219 168.994 169.633 1.00 56.69  ? 581  TYR A CG  1 
ATOM   3367 C  CD1 . TYR A 1 591 ? 129.327 168.804 170.449 1.00 56.69  ? 581  TYR A CD1 1 
ATOM   3368 C  CD2 . TYR A 1 591 ? 127.693 170.275 169.535 1.00 56.69  ? 581  TYR A CD2 1 
ATOM   3369 C  CE1 . TYR A 1 591 ? 129.891 169.855 171.144 1.00 56.69  ? 581  TYR A CE1 1 
ATOM   3370 C  CE2 . TYR A 1 591 ? 128.252 171.332 170.225 1.00 56.69  ? 581  TYR A CE2 1 
ATOM   3371 C  CZ  . TYR A 1 591 ? 129.349 171.116 171.027 1.00 56.69  ? 581  TYR A CZ  1 
ATOM   3372 O  OH  . TYR A 1 591 ? 129.906 172.167 171.717 1.00 56.69  ? 581  TYR A OH  1 
ATOM   3373 N  N   . GLU A 1 592 ? 125.259 166.927 170.882 1.00 62.67  ? 582  GLU A N   1 
ATOM   3374 C  CA  . GLU A 1 592 ? 124.440 167.281 172.040 1.00 62.67  ? 582  GLU A CA  1 
ATOM   3375 C  C   . GLU A 1 592 ? 123.034 166.740 171.847 1.00 62.67  ? 582  GLU A C   1 
ATOM   3376 O  O   . GLU A 1 592 ? 122.377 167.069 170.854 1.00 62.67  ? 582  GLU A O   1 
ATOM   3377 C  CB  . GLU A 1 592 ? 124.407 168.797 172.239 1.00 62.67  ? 582  GLU A CB  1 
ATOM   3378 C  CG  . GLU A 1 592 ? 123.680 169.241 173.495 1.00 62.67  ? 582  GLU A CG  1 
ATOM   3379 C  CD  . GLU A 1 592 ? 122.918 170.535 173.298 1.00 62.67  ? 582  GLU A CD  1 
ATOM   3380 O  OE1 . GLU A 1 592 ? 123.280 171.304 172.384 1.00 62.67  ? 582  GLU A OE1 1 
ATOM   3381 O  OE2 . GLU A 1 592 ? 121.958 170.783 174.056 1.00 62.67  ? 582  GLU A OE2 1 
ATOM   3382 N  N   . LYS A 1 593 ? 122.572 165.921 172.791 1.00 55.96  ? 583  LYS A N   1 
ATOM   3383 C  CA  . LYS A 1 593 ? 121.190 165.465 172.805 1.00 55.96  ? 583  LYS A CA  1 
ATOM   3384 C  C   . LYS A 1 593 ? 120.802 165.115 174.235 1.00 55.96  ? 583  LYS A C   1 
ATOM   3385 O  O   . LYS A 1 593 ? 121.654 164.805 175.072 1.00 55.96  ? 583  LYS A O   1 
ATOM   3386 C  CB  . LYS A 1 593 ? 120.975 164.268 171.870 1.00 55.96  ? 583  LYS A CB  1 
ATOM   3387 C  CG  . LYS A 1 593 ? 121.605 162.969 172.334 1.00 55.96  ? 583  LYS A CG  1 
ATOM   3388 C  CD  . LYS A 1 593 ? 121.285 161.846 171.363 1.00 55.96  ? 583  LYS A CD  1 
ATOM   3389 C  CE  . LYS A 1 593 ? 121.794 160.512 171.869 1.00 55.96  ? 583  LYS A CE  1 
ATOM   3390 N  NZ  . LYS A 1 593 ? 121.452 159.405 170.935 1.00 55.96  ? 583  LYS A NZ  1 
ATOM   3391 N  N   . ASN A 1 594 ? 119.501 165.176 174.508 1.00 48.92  ? 584  ASN A N   1 
ATOM   3392 C  CA  . ASN A 1 594 ? 118.967 164.978 175.854 1.00 48.92  ? 584  ASN A CA  1 
ATOM   3393 C  C   . ASN A 1 594 ? 117.749 164.059 175.812 1.00 48.92  ? 584  ASN A C   1 
ATOM   3394 O  O   . ASN A 1 594 ? 116.705 164.339 176.401 1.00 48.92  ? 584  ASN A O   1 
ATOM   3395 C  CB  . ASN A 1 594 ? 118.626 166.320 176.498 1.00 48.92  ? 584  ASN A CB  1 
ATOM   3396 C  CG  . ASN A 1 594 ? 118.527 166.235 178.006 1.00 48.92  ? 584  ASN A CG  1 
ATOM   3397 O  OD1 . ASN A 1 594 ? 119.527 166.351 178.713 1.00 48.92  ? 584  ASN A OD1 1 
ATOM   3398 N  ND2 . ASN A 1 594 ? 117.316 166.030 178.507 1.00 48.92  ? 584  ASN A ND2 1 
ATOM   3399 N  N   . LYS A 1 595 ? 117.873 162.943 175.101 1.00 44.08  ? 585  LYS A N   1 
ATOM   3400 C  CA  . LYS A 1 595 ? 116.765 162.009 174.952 1.00 44.08  ? 585  LYS A CA  1 
ATOM   3401 C  C   . LYS A 1 595 ? 116.651 161.109 176.178 1.00 44.08  ? 585  LYS A C   1 
ATOM   3402 O  O   . LYS A 1 595 ? 117.658 160.683 176.748 1.00 44.08  ? 585  LYS A O   1 
ATOM   3403 C  CB  . LYS A 1 595 ? 116.955 161.164 173.693 1.00 44.08  ? 585  LYS A CB  1 
ATOM   3404 C  CG  . LYS A 1 595 ? 117.252 161.967 172.434 1.00 44.08  ? 585  LYS A CG  1 
ATOM   3405 C  CD  . LYS A 1 595 ? 116.252 163.094 172.235 1.00 44.08  ? 585  LYS A CD  1 
ATOM   3406 C  CE  . LYS A 1 595 ? 116.641 163.979 171.065 1.00 44.08  ? 585  LYS A CE  1 
ATOM   3407 N  NZ  . LYS A 1 595 ? 116.720 163.210 169.795 1.00 44.08  ? 585  LYS A NZ  1 
ATOM   3408 N  N   . THR A 1 596 ? 115.413 160.824 176.585 1.00 36.38  ? 586  THR A N   1 
ATOM   3409 C  CA  . THR A 1 596 ? 115.132 160.070 177.799 1.00 36.38  ? 586  THR A CA  1 
ATOM   3410 C  C   . THR A 1 596 ? 114.293 158.838 177.486 1.00 36.38  ? 586  THR A C   1 
ATOM   3411 O  O   . THR A 1 596 ? 113.488 158.838 176.551 1.00 36.38  ? 586  THR A O   1 
ATOM   3412 C  CB  . THR A 1 596 ? 114.382 160.919 178.835 1.00 36.38  ? 586  THR A CB  1 
ATOM   3413 O  OG1 . THR A 1 596 ? 113.011 161.044 178.443 1.00 36.38  ? 586  THR A OG1 1 
ATOM   3414 C  CG2 . THR A 1 596 ? 114.987 162.306 178.943 1.00 36.38  ? 586  THR A CG2 1 
ATOM   3415 N  N   . PHE A 1 597 ? 114.489 157.785 178.277 1.00 35.57  ? 587  PHE A N   1 
ATOM   3416 C  CA  . PHE A 1 597 ? 113.622 156.615 178.210 1.00 35.57  ? 587  PHE A CA  1 
ATOM   3417 C  C   . PHE A 1 597 ? 113.508 156.004 179.598 1.00 35.57  ? 587  PHE A C   1 
ATOM   3418 O  O   . PHE A 1 597 ? 114.436 156.090 180.403 1.00 35.57  ? 587  PHE A O   1 
ATOM   3419 C  CB  . PHE A 1 597 ? 114.126 155.584 177.188 1.00 35.57  ? 587  PHE A CB  1 
ATOM   3420 C  CG  . PHE A 1 597 ? 115.378 154.858 177.601 1.00 35.57  ? 587  PHE A CG  1 
ATOM   3421 C  CD1 . PHE A 1 597 ? 116.624 155.394 177.332 1.00 35.57  ? 587  PHE A CD1 1 
ATOM   3422 C  CD2 . PHE A 1 597 ? 115.310 153.618 178.218 1.00 35.57  ? 587  PHE A CD2 1 
ATOM   3423 C  CE1 . PHE A 1 597 ? 117.777 154.725 177.695 1.00 35.57  ? 587  PHE A CE1 1 
ATOM   3424 C  CE2 . PHE A 1 597 ? 116.460 152.946 178.585 1.00 35.57  ? 587  PHE A CE2 1 
ATOM   3425 C  CZ  . PHE A 1 597 ? 117.694 153.501 178.323 1.00 35.57  ? 587  PHE A CZ  1 
ATOM   3426 N  N   . PHE A 1 598 ? 112.366 155.383 179.877 1.00 30.86  ? 588  PHE A N   1 
ATOM   3427 C  CA  . PHE A 1 598 ? 112.098 154.848 181.203 1.00 30.86  ? 588  PHE A CA  1 
ATOM   3428 C  C   . PHE A 1 598 ? 112.331 153.342 181.241 1.00 30.86  ? 588  PHE A C   1 
ATOM   3429 O  O   . PHE A 1 598 ? 112.347 152.664 180.214 1.00 30.86  ? 588  PHE A O   1 
ATOM   3430 C  CB  . PHE A 1 598 ? 110.665 155.161 181.636 1.00 30.86  ? 588  PHE A CB  1 
ATOM   3431 C  CG  . PHE A 1 598 ? 110.276 156.597 181.453 1.00 30.86  ? 588  PHE A CG  1 
ATOM   3432 C  CD1 . PHE A 1 598 ? 110.642 157.549 182.384 1.00 30.86  ? 588  PHE A CD1 1 
ATOM   3433 C  CD2 . PHE A 1 598 ? 109.535 156.992 180.354 1.00 30.86  ? 588  PHE A CD2 1 
ATOM   3434 C  CE1 . PHE A 1 598 ? 110.283 158.871 182.221 1.00 30.86  ? 588  PHE A CE1 1 
ATOM   3435 C  CE2 . PHE A 1 598 ? 109.173 158.312 180.185 1.00 30.86  ? 588  PHE A CE2 1 
ATOM   3436 C  CZ  . PHE A 1 598 ? 109.547 159.252 181.120 1.00 30.86  ? 588  PHE A CZ  1 
ATOM   3437 N  N   . LEU A 1 599 ? 112.499 152.825 182.454 1.00 24.89  ? 589  LEU A N   1 
ATOM   3438 C  CA  . LEU A 1 599 ? 112.669 151.395 182.682 1.00 24.89  ? 589  LEU A CA  1 
ATOM   3439 C  C   . LEU A 1 599 ? 111.906 151.038 183.947 1.00 24.89  ? 589  LEU A C   1 
ATOM   3440 O  O   . LEU A 1 599 ? 112.146 151.632 185.002 1.00 24.89  ? 589  LEU A O   1 
ATOM   3441 C  CB  . LEU A 1 599 ? 114.150 151.033 182.808 1.00 24.89  ? 589  LEU A CB  1 
ATOM   3442 C  CG  . LEU A 1 599 ? 114.528 149.560 182.682 1.00 24.89  ? 589  LEU A CG  1 
ATOM   3443 C  CD1 . LEU A 1 599 ? 115.780 149.429 181.851 1.00 24.89  ? 589  LEU A CD1 1 
ATOM   3444 C  CD2 . LEU A 1 599 ? 114.741 148.933 184.035 1.00 24.89  ? 589  LEU A CD2 1 
ATOM   3445 N  N   . GLU A 1 600 ? 110.985 150.083 183.846 1.00 29.97  ? 590  GLU A N   1 
ATOM   3446 C  CA  . GLU A 1 600 ? 110.037 149.817 184.917 1.00 29.97  ? 590  GLU A CA  1 
ATOM   3447 C  C   . GLU A 1 600 ? 110.024 148.340 185.277 1.00 29.97  ? 590  GLU A C   1 
ATOM   3448 O  O   . GLU A 1 600 ? 110.090 147.475 184.398 1.00 29.97  ? 590  GLU A O   1 
ATOM   3449 C  CB  . GLU A 1 600 ? 108.628 150.263 184.518 1.00 29.97  ? 590  GLU A CB  1 
ATOM   3450 C  CG  . GLU A 1 600 ? 107.636 150.285 185.665 1.00 29.97  ? 590  GLU A CG  1 
ATOM   3451 C  CD  . GLU A 1 600 ? 106.336 150.969 185.300 1.00 29.97  ? 590  GLU A CD  1 
ATOM   3452 O  OE1 . GLU A 1 600 ? 106.104 151.204 184.096 1.00 29.97  ? 590  GLU A OE1 1 
ATOM   3453 O  OE2 . GLU A 1 600 ? 105.545 151.271 186.217 1.00 29.97  ? 590  GLU A OE2 1 
ATOM   3454 N  N   . ILE A 1 601 ? 109.916 148.058 186.574 1.00 25.57  ? 591  ILE A N   1 
ATOM   3455 C  CA  . ILE A 1 601 ? 109.793 146.700 187.088 1.00 25.57  ? 591  ILE A CA  1 
ATOM   3456 C  C   . ILE A 1 601 ? 108.375 146.497 187.605 1.00 25.57  ? 591  ILE A C   1 
ATOM   3457 O  O   . ILE A 1 601 ? 107.801 147.381 188.251 1.00 25.57  ? 591  ILE A O   1 
ATOM   3458 C  CB  . ILE A 1 601 ? 110.835 146.394 188.184 1.00 25.57  ? 591  ILE A CB  1 
ATOM   3459 C  CG1 . ILE A 1 601 ? 110.761 147.406 189.326 1.00 25.57  ? 591  ILE A CG1 1 
ATOM   3460 C  CG2 . ILE A 1 601 ? 112.230 146.368 187.596 1.00 25.57  ? 591  ILE A CG2 1 
ATOM   3461 C  CD1 . ILE A 1 601 ? 111.667 147.073 190.482 1.00 25.57  ? 591  ILE A CD1 1 
ATOM   3462 N  N   . GLY A 1 602 ? 107.799 145.340 187.290 1.00 41.22  ? 592  GLY A N   1 
ATOM   3463 C  CA  . GLY A 1 602 ? 106.429 145.038 187.638 1.00 41.22  ? 592  GLY A CA  1 
ATOM   3464 C  C   . GLY A 1 602 ? 106.297 144.401 189.006 1.00 41.22  ? 592  GLY A C   1 
ATOM   3465 O  O   . GLY A 1 602 ? 107.215 144.409 189.827 1.00 41.22  ? 592  GLY A O   1 
ATOM   3466 N  N   . GLU A 1 603 ? 105.117 143.847 189.248 1.00 41.22  ? 593  GLU A N   1 
ATOM   3467 C  CA  . GLU A 1 603 ? 104.841 143.194 190.521 1.00 41.22  ? 593  GLU A CA  1 
ATOM   3468 C  C   . GLU A 1 603 ? 105.599 141.875 190.605 1.00 41.22  ? 593  GLU A C   1 
ATOM   3469 O  O   . GLU A 1 603 ? 105.496 141.050 189.691 1.00 41.22  ? 593  GLU A O   1 
ATOM   3470 C  CB  . GLU A 1 603 ? 103.344 142.950 190.676 1.00 41.22  ? 593  GLU A CB  1 
ATOM   3471 C  CG  . GLU A 1 603 ? 102.970 142.153 191.909 1.00 41.22  ? 593  GLU A CG  1 
ATOM   3472 C  CD  . GLU A 1 603 ? 102.790 143.025 193.132 1.00 41.22  ? 593  GLU A CD  1 
ATOM   3473 O  OE1 . GLU A 1 603 ? 102.609 144.249 192.965 1.00 41.22  ? 593  GLU A OE1 1 
ATOM   3474 O  OE2 . GLU A 1 603 ? 102.825 142.490 194.259 1.00 41.22  ? 593  GLU A OE2 1 
ATOM   3475 N  N   . PRO A 1 604 ? 106.361 141.637 191.668 1.00 28.08  ? 594  PRO A N   1 
ATOM   3476 C  CA  . PRO A 1 604 ? 107.117 140.390 191.786 1.00 28.08  ? 594  PRO A CA  1 
ATOM   3477 C  C   . PRO A 1 604 ? 106.322 139.273 192.440 1.00 28.08  ? 594  PRO A C   1 
ATOM   3478 O  O   . PRO A 1 604 ? 105.436 139.496 193.266 1.00 28.08  ? 594  PRO A O   1 
ATOM   3479 C  CB  . PRO A 1 604 ? 108.303 140.802 192.665 1.00 28.08  ? 594  PRO A CB  1 
ATOM   3480 C  CG  . PRO A 1 604 ? 107.756 141.877 193.535 1.00 28.08  ? 594  PRO A CG  1 
ATOM   3481 C  CD  . PRO A 1 604 ? 106.616 142.542 192.800 1.00 28.08  ? 594  PRO A CD  1 
ATOM   3482 N  N   . ARG A 1 605 ? 106.655 138.042 192.049 1.00 27.20  ? 595  ARG A N   1 
ATOM   3483 C  CA  . ARG A 1 605 ? 105.969 136.852 192.537 1.00 27.20  ? 595  ARG A CA  1 
ATOM   3484 C  C   . ARG A 1 605 ? 106.979 135.849 193.073 1.00 27.20  ? 595  ARG A C   1 
ATOM   3485 O  O   . ARG A 1 605 ? 107.941 135.502 192.382 1.00 27.20  ? 595  ARG A O   1 
ATOM   3486 C  CB  . ARG A 1 605 ? 105.131 136.197 191.433 1.00 27.20  ? 595  ARG A CB  1 
ATOM   3487 C  CG  . ARG A 1 605 ? 104.449 137.165 190.487 1.00 27.20  ? 595  ARG A CG  1 
ATOM   3488 C  CD  . ARG A 1 605 ? 103.718 136.425 189.383 1.00 27.20  ? 595  ARG A CD  1 
ATOM   3489 N  NE  . ARG A 1 605 ? 104.593 135.517 188.653 1.00 27.20  ? 595  ARG A NE  1 
ATOM   3490 C  CZ  . ARG A 1 605 ? 105.454 135.894 187.718 1.00 27.20  ? 595  ARG A CZ  1 
ATOM   3491 N  NH1 . ARG A 1 605 ? 105.577 137.161 187.361 1.00 27.20  ? 595  ARG A NH1 1 
ATOM   3492 N  NH2 . ARG A 1 605 ? 106.206 134.974 187.121 1.00 27.20  ? 595  ARG A NH2 1 
ATOM   3493 N  N   . LEU A 1 606 ? 106.751 135.386 194.299 1.00 28.51  ? 596  LEU A N   1 
ATOM   3494 C  CA  . LEU A 1 606 ? 107.539 134.301 194.870 1.00 28.51  ? 596  LEU A CA  1 
ATOM   3495 C  C   . LEU A 1 606 ? 107.179 132.987 194.189 1.00 28.51  ? 596  LEU A C   1 
ATOM   3496 O  O   . LEU A 1 606 ? 106.014 132.748 193.867 1.00 28.51  ? 596  LEU A O   1 
ATOM   3497 C  CB  . LEU A 1 606 ? 107.277 134.210 196.371 1.00 28.51  ? 596  LEU A CB  1 
ATOM   3498 C  CG  . LEU A 1 606 ? 107.951 133.110 197.180 1.00 28.51  ? 596  LEU A CG  1 
ATOM   3499 C  CD1 . LEU A 1 606 ? 109.384 133.484 197.473 1.00 28.51  ? 596  LEU A CD1 1 
ATOM   3500 C  CD2 . LEU A 1 606 ? 107.189 132.880 198.466 1.00 28.51  ? 596  LEU A CD2 1 
ATOM   3501 N  N   . VAL A 1 607 ? 108.179 132.134 193.949 1.00 41.22  ? 597  VAL A N   1 
ATOM   3502 C  CA  . VAL A 1 607 ? 107.975 130.868 193.240 1.00 41.22  ? 597  VAL A CA  1 
ATOM   3503 C  C   . VAL A 1 607 ? 108.283 129.640 194.109 1.00 41.22  ? 597  VAL A C   1 
ATOM   3504 O  O   . VAL A 1 607 ? 107.389 128.845 194.401 1.00 41.22  ? 597  VAL A O   1 
ATOM   3505 C  CB  . VAL A 1 607 ? 108.737 130.839 191.895 1.00 41.22  ? 597  VAL A CB  1 
ATOM   3506 C  CG1 . VAL A 1 607 ? 108.166 131.887 191.018 1.00 41.22  ? 597  VAL A CG1 1 
ATOM   3507 C  CG2 . VAL A 1 607 ? 110.211 131.169 192.052 1.00 41.22  ? 597  VAL A CG2 1 
ATOM   3508 N  N   . GLU A 1 608 ? 109.529 129.475 194.544 1.00 41.22  ? 598  GLU A N   1 
ATOM   3509 C  CA  . GLU A 1 608 ? 109.918 128.226 195.182 1.00 41.22  ? 598  GLU A CA  1 
ATOM   3510 C  C   . GLU A 1 608 ? 109.906 128.380 196.695 1.00 41.22  ? 598  GLU A C   1 
ATOM   3511 O  O   . GLU A 1 608 ? 110.263 129.431 197.235 1.00 41.22  ? 598  GLU A O   1 
ATOM   3512 C  CB  . GLU A 1 608 ? 111.282 127.731 194.687 1.00 41.22  ? 598  GLU A CB  1 
ATOM   3513 C  CG  . GLU A 1 608 ? 112.505 128.346 195.323 1.00 41.22  ? 598  GLU A CG  1 
ATOM   3514 C  CD  . GLU A 1 608 ? 113.739 128.195 194.454 1.00 41.22  ? 598  GLU A CD  1 
ATOM   3515 O  OE1 . GLU A 1 608 ? 113.610 127.686 193.321 1.00 41.22  ? 598  GLU A OE1 1 
ATOM   3516 O  OE2 . GLU A 1 608 ? 114.837 128.585 194.902 1.00 41.22  ? 598  GLU A OE2 1 
ATOM   3517 N  N   . MET A 1 609 ? 109.457 127.328 197.369 1.00 30.68  ? 599  MET A N   1 
ATOM   3518 C  CA  . MET A 1 609 ? 109.100 127.422 198.775 1.00 30.68  ? 599  MET A CA  1 
ATOM   3519 C  C   . MET A 1 609 ? 109.054 126.030 199.382 1.00 30.68  ? 599  MET A C   1 
ATOM   3520 O  O   . MET A 1 609 ? 109.013 125.024 198.673 1.00 30.68  ? 599  MET A O   1 
ATOM   3521 C  CB  . MET A 1 609 ? 107.750 128.122 198.939 1.00 30.68  ? 599  MET A CB  1 
ATOM   3522 C  CG  . MET A 1 609 ? 106.718 127.692 197.911 1.00 30.68  ? 599  MET A CG  1 
ATOM   3523 S  SD  . MET A 1 609 ? 105.093 128.413 198.182 1.00 30.68  ? 599  MET A SD  1 
ATOM   3524 C  CE  . MET A 1 609 ? 105.255 129.945 197.278 1.00 30.68  ? 599  MET A CE  1 
ATOM   3525 N  N   . SER A 1 610 ? 109.049 125.987 200.709 1.00 27.51  ? 600  SER A N   1 
ATOM   3526 C  CA  . SER A 1 610 ? 108.830 124.734 201.407 1.00 27.51  ? 600  SER A CA  1 
ATOM   3527 C  C   . SER A 1 610 ? 107.350 124.362 201.361 1.00 27.51  ? 600  SER A C   1 
ATOM   3528 O  O   . SER A 1 610 ? 106.501 125.130 200.903 1.00 27.51  ? 600  SER A O   1 
ATOM   3529 C  CB  . SER A 1 610 ? 109.324 124.830 202.848 1.00 27.51  ? 600  SER A CB  1 
ATOM   3530 O  OG  . SER A 1 610 ? 108.635 125.840 203.561 1.00 27.51  ? 600  SER A OG  1 
ATOM   3531 N  N   . GLU A 1 611 ? 107.042 123.151 201.830 1.00 29.92  ? 601  GLU A N   1 
ATOM   3532 C  CA  . GLU A 1 611 ? 105.660 122.683 201.804 1.00 29.92  ? 601  GLU A CA  1 
ATOM   3533 C  C   . GLU A 1 611 ? 104.794 123.431 202.813 1.00 29.92  ? 601  GLU A C   1 
ATOM   3534 O  O   . GLU A 1 611 ? 103.648 123.787 202.512 1.00 29.92  ? 601  GLU A O   1 
ATOM   3535 C  CB  . GLU A 1 611 ? 105.611 121.179 202.067 1.00 29.92  ? 601  GLU A CB  1 
ATOM   3536 C  CG  . GLU A 1 611 ? 104.204 120.612 202.168 1.00 29.92  ? 601  GLU A CG  1 
ATOM   3537 C  CD  . GLU A 1 611 ? 104.181 119.193 202.698 1.00 29.92  ? 601  GLU A CD  1 
ATOM   3538 O  OE1 . GLU A 1 611 ? 105.162 118.455 202.469 1.00 29.92  ? 601  GLU A OE1 1 
ATOM   3539 O  OE2 . GLU A 1 611 ? 103.182 118.815 203.345 1.00 29.92  ? 601  GLU A OE2 1 
ATOM   3540 N  N   . LYS A 1 612 ? 105.321 123.668 204.016 1.00 30.18  ? 602  LYS A N   1 
ATOM   3541 C  CA  . LYS A 1 612 ? 104.537 124.326 205.058 1.00 30.18  ? 602  LYS A CA  1 
ATOM   3542 C  C   . LYS A 1 612 ? 104.218 125.770 204.687 1.00 30.18  ? 602  LYS A C   1 
ATOM   3543 O  O   . LYS A 1 612 ? 103.099 126.243 204.923 1.00 30.18  ? 602  LYS A O   1 
ATOM   3544 C  CB  . LYS A 1 612 ? 105.283 124.257 206.390 1.00 30.18  ? 602  LYS A CB  1 
ATOM   3545 C  CG  . LYS A 1 612 ? 104.405 124.442 207.613 1.00 30.18  ? 602  LYS A CG  1 
ATOM   3546 C  CD  . LYS A 1 612 ? 105.219 124.307 208.891 1.00 30.18  ? 602  LYS A CD  1 
ATOM   3547 C  CE  . LYS A 1 612 ? 104.328 124.076 210.100 1.00 30.18  ? 602  LYS A CE  1 
ATOM   3548 N  NZ  . LYS A 1 612 ? 103.204 125.049 210.160 1.00 30.18  ? 602  LYS A NZ  1 
ATOM   3549 N  N   . LYS A 1 613 ? 105.183 126.484 204.101 1.00 25.51  ? 603  LYS A N   1 
ATOM   3550 C  CA  . LYS A 1 613 ? 104.911 127.836 203.624 1.00 25.51  ? 603  LYS A CA  1 
ATOM   3551 C  C   . LYS A 1 613 ? 103.886 127.820 202.498 1.00 25.51  ? 603  LYS A C   1 
ATOM   3552 O  O   . LYS A 1 613 ? 103.040 128.717 202.406 1.00 25.51  ? 603  LYS A O   1 
ATOM   3553 C  CB  . LYS A 1 613 ? 106.206 128.512 203.170 1.00 25.51  ? 603  LYS A CB  1 
ATOM   3554 C  CG  . LYS A 1 613 ? 105.991 129.819 202.424 1.00 25.51  ? 603  LYS A CG  1 
ATOM   3555 C  CD  . LYS A 1 613 ? 107.252 130.321 201.754 1.00 25.51  ? 603  LYS A CD  1 
ATOM   3556 C  CE  . LYS A 1 613 ? 108.049 131.222 202.667 1.00 25.51  ? 603  LYS A CE  1 
ATOM   3557 N  NZ  . LYS A 1 613 ? 109.042 132.023 201.902 1.00 25.51  ? 603  LYS A NZ  1 
ATOM   3558 N  N   . ALA A 1 614 ? 103.939 126.802 201.635 1.00 28.67  ? 604  ALA A N   1 
ATOM   3559 C  CA  . ALA A 1 614 ? 102.961 126.687 200.557 1.00 28.67  ? 604  ALA A CA  1 
ATOM   3560 C  C   . ALA A 1 614 ? 101.558 126.458 201.101 1.00 28.67  ? 604  ALA A C   1 
ATOM   3561 O  O   . ALA A 1 614 ? 100.579 126.970 200.546 1.00 28.67  ? 604  ALA A O   1 
ATOM   3562 C  CB  . ALA A 1 614 ? 103.356 125.561 199.606 1.00 28.67  ? 604  ALA A CB  1 
ATOM   3563 N  N   . LEU A 1 615 ? 101.436 125.673 202.172 1.00 32.66  ? 605  LEU A N   1 
ATOM   3564 C  CA  . LEU A 1 615 ? 100.136 125.510 202.817 1.00 32.66  ? 605  LEU A CA  1 
ATOM   3565 C  C   . LEU A 1 615 ? 99.672  126.800 203.482 1.00 32.66  ? 605  LEU A C   1 
ATOM   3566 O  O   . LEU A 1 615 ? 98.484  127.137 203.424 1.00 32.66  ? 605  LEU A O   1 
ATOM   3567 C  CB  . LEU A 1 615 ? 100.185 124.375 203.838 1.00 32.66  ? 605  LEU A CB  1 
ATOM   3568 C  CG  . LEU A 1 615 ? 99.911  122.964 203.320 1.00 32.66  ? 605  LEU A CG  1 
ATOM   3569 C  CD1 . LEU A 1 615 ? 99.607  122.032 204.477 1.00 32.66  ? 605  LEU A CD1 1 
ATOM   3570 C  CD2 . LEU A 1 615 ? 98.748  122.987 202.347 1.00 32.66  ? 605  LEU A CD2 1 
ATOM   3571 N  N   . LEU A 1 616 ? 100.586 127.526 204.132 1.00 36.17  ? 606  LEU A N   1 
ATOM   3572 C  CA  . LEU A 1 616 ? 100.190 128.742 204.840 1.00 36.17  ? 606  LEU A CA  1 
ATOM   3573 C  C   . LEU A 1 616 ? 99.769  129.846 203.876 1.00 36.17  ? 606  LEU A C   1 
ATOM   3574 O  O   . LEU A 1 616 ? 98.772  130.537 204.114 1.00 36.17  ? 606  LEU A O   1 
ATOM   3575 C  CB  . LEU A 1 616 ? 101.321 129.222 205.748 1.00 36.17  ? 606  LEU A CB  1 
ATOM   3576 C  CG  . LEU A 1 616 ? 101.649 128.367 206.976 1.00 36.17  ? 606  LEU A CG  1 
ATOM   3577 C  CD1 . LEU A 1 616 ? 102.306 129.215 208.047 1.00 36.17  ? 606  LEU A CD1 1 
ATOM   3578 C  CD2 . LEU A 1 616 ? 100.409 127.684 207.533 1.00 36.17  ? 606  LEU A CD2 1 
ATOM   3579 N  N   . LEU A 1 617 ? 100.511 130.031 202.784 1.00 32.61  ? 607  LEU A N   1 
ATOM   3580 C  CA  . LEU A 1 617 ? 100.143 131.026 201.784 1.00 32.61  ? 607  LEU A CA  1 
ATOM   3581 C  C   . LEU A 1 617 ? 98.987  130.570 200.904 1.00 32.61  ? 607  LEU A C   1 
ATOM   3582 O  O   . LEU A 1 617 ? 98.471  131.383 200.130 1.00 32.61  ? 607  LEU A O   1 
ATOM   3583 C  CB  . LEU A 1 617 ? 101.349 131.377 200.909 1.00 32.61  ? 607  LEU A CB  1 
ATOM   3584 C  CG  . LEU A 1 617 ? 102.267 132.515 201.365 1.00 32.61  ? 607  LEU A CG  1 
ATOM   3585 C  CD1 . LEU A 1 617 ? 103.044 132.146 202.616 1.00 32.61  ? 607  LEU A CD1 1 
ATOM   3586 C  CD2 . LEU A 1 617 ? 103.215 132.919 200.250 1.00 32.61  ? 607  LEU A CD2 1 
ATOM   3587 N  N   . ASN A 1 618 ? 98.594  129.295 200.996 1.00 36.88  ? 608  ASN A N   1 
ATOM   3588 C  CA  . ASN A 1 618 ? 97.439  128.739 200.284 1.00 36.88  ? 608  ASN A CA  1 
ATOM   3589 C  C   . ASN A 1 618 ? 97.602  128.837 198.769 1.00 36.88  ? 608  ASN A C   1 
ATOM   3590 O  O   . ASN A 1 618 ? 96.686  129.244 198.053 1.00 36.88  ? 608  ASN A O   1 
ATOM   3591 C  CB  . ASN A 1 618 ? 96.133  129.398 200.735 1.00 36.88  ? 608  ASN A CB  1 
ATOM   3592 C  CG  . ASN A 1 618 ? 94.933  128.498 200.546 1.00 36.88  ? 608  ASN A CG  1 
ATOM   3593 O  OD1 . ASN A 1 618 ? 95.058  127.375 200.059 1.00 36.88  ? 608  ASN A OD1 1 
ATOM   3594 N  ND2 . ASN A 1 618 ? 93.760  128.986 200.929 1.00 36.88  ? 608  ASN A ND2 1 
ATOM   3595 N  N   . GLU A 1 619 ? 98.781  128.468 198.276 1.00 36.91  ? 609  GLU A N   1 
ATOM   3596 C  CA  . GLU A 1 619 ? 99.005  128.418 196.838 1.00 36.91  ? 609  GLU A CA  1 
ATOM   3597 C  C   . GLU A 1 619 ? 98.259  127.238 196.227 1.00 36.91  ? 609  GLU A C   1 
ATOM   3598 O  O   . GLU A 1 619 ? 98.190  126.154 196.813 1.00 36.91  ? 609  GLU A O   1 
ATOM   3599 C  CB  . GLU A 1 619 ? 100.497 128.313 196.537 1.00 36.91  ? 609  GLU A CB  1 
ATOM   3600 C  CG  . GLU A 1 619 ? 101.299 129.527 196.975 1.00 36.91  ? 609  GLU A CG  1 
ATOM   3601 C  CD  . GLU A 1 619 ? 101.275 130.642 195.949 1.00 36.91  ? 609  GLU A CD  1 
ATOM   3602 O  OE1 . GLU A 1 619 ? 100.804 130.398 194.819 1.00 36.91  ? 609  GLU A OE1 1 
ATOM   3603 O  OE2 . GLU A 1 619 ? 101.726 131.761 196.273 1.00 36.91  ? 609  GLU A OE2 1 
ATOM   3604 N  N   . LEU A 1 620 ? 97.697  127.454 195.036 1.00 35.25  ? 610  LEU A N   1 
ATOM   3605 C  CA  . LEU A 1 620 ? 96.879  126.452 194.369 1.00 35.25  ? 610  LEU A CA  1 
ATOM   3606 C  C   . LEU A 1 620 ? 97.490  125.916 193.082 1.00 35.25  ? 610  LEU A C   1 
ATOM   3607 O  O   . LEU A 1 620 ? 96.977  124.932 192.540 1.00 35.25  ? 610  LEU A O   1 
ATOM   3608 C  CB  . LEU A 1 620 ? 95.489  127.027 194.059 1.00 35.25  ? 610  LEU A CB  1 
ATOM   3609 C  CG  . LEU A 1 620 ? 94.731  127.648 195.232 1.00 35.25  ? 610  LEU A CG  1 
ATOM   3610 C  CD1 . LEU A 1 620 ? 93.633  128.569 194.734 1.00 35.25  ? 610  LEU A CD1 1 
ATOM   3611 C  CD2 . LEU A 1 620 ? 94.154  126.565 196.124 1.00 35.25  ? 610  LEU A CD2 1 
ATOM   3612 N  N   . GLY A 1 621 ? 98.563  126.520 192.585 1.00 34.68  ? 611  GLY A N   1 
ATOM   3613 C  CA  . GLY A 1 621 ? 99.123  126.141 191.306 1.00 34.68  ? 611  GLY A CA  1 
ATOM   3614 C  C   . GLY A 1 621 ? 99.877  124.825 191.358 1.00 34.68  ? 611  GLY A C   1 
ATOM   3615 O  O   . GLY A 1 621 ? 99.945  124.135 192.375 1.00 34.68  ? 611  GLY A O   1 
ATOM   3616 N  N   . GLY A 1 622 ? 100.448 124.469 190.209 1.00 32.35  ? 612  GLY A N   1 
ATOM   3617 C  CA  . GLY A 1 622 ? 101.219 123.241 190.113 1.00 32.35  ? 612  GLY A CA  1 
ATOM   3618 C  C   . GLY A 1 622 ? 102.609 123.403 190.708 1.00 32.35  ? 612  GLY A C   1 
ATOM   3619 O  O   . GLY A 1 622 ? 103.279 124.417 190.520 1.00 32.35  ? 612  GLY A O   1 
ATOM   3620 N  N   . PHE A 1 623 ? 103.042 122.374 191.432 1.00 29.63  ? 613  PHE A N   1 
ATOM   3621 C  CA  . PHE A 1 623 ? 104.328 122.370 192.116 1.00 29.63  ? 613  PHE A CA  1 
ATOM   3622 C  C   . PHE A 1 623 ? 105.169 121.213 191.600 1.00 29.63  ? 613  PHE A C   1 
ATOM   3623 O  O   . PHE A 1 623 ? 104.745 120.055 191.668 1.00 29.63  ? 613  PHE A O   1 
ATOM   3624 C  CB  . PHE A 1 623 ? 104.140 122.248 193.628 1.00 29.63  ? 613  PHE A CB  1 
ATOM   3625 C  CG  . PHE A 1 623 ? 103.863 123.549 194.316 1.00 29.63  ? 613  PHE A CG  1 
ATOM   3626 C  CD1 . PHE A 1 623 ? 104.825 124.537 194.369 1.00 29.63  ? 613  PHE A CD1 1 
ATOM   3627 C  CD2 . PHE A 1 623 ? 102.635 123.784 194.904 1.00 29.63  ? 613  PHE A CD2 1 
ATOM   3628 C  CE1 . PHE A 1 623 ? 104.574 125.724 195.009 1.00 29.63  ? 613  PHE A CE1 1 
ATOM   3629 C  CE2 . PHE A 1 623 ? 102.377 124.975 195.540 1.00 29.63  ? 613  PHE A CE2 1 
ATOM   3630 C  CZ  . PHE A 1 623 ? 103.346 125.948 195.588 1.00 29.63  ? 613  PHE A CZ  1 
ATOM   3631 N  N   . THR A 1 624 ? 106.360 121.525 191.102 1.00 25.83  ? 614  THR A N   1 
ATOM   3632 C  CA  . THR A 1 624 ? 107.350 120.521 190.744 1.00 25.83  ? 614  THR A CA  1 
ATOM   3633 C  C   . THR A 1 624 ? 108.334 120.385 191.895 1.00 25.83  ? 614  THR A C   1 
ATOM   3634 O  O   . THR A 1 624 ? 108.866 121.389 192.382 1.00 25.83  ? 614  THR A O   1 
ATOM   3635 C  CB  . THR A 1 624 ? 108.092 120.897 189.462 1.00 25.83  ? 614  THR A CB  1 
ATOM   3636 O  OG1 . THR A 1 624 ? 109.001 121.970 189.730 1.00 25.83  ? 614  THR A OG1 1 
ATOM   3637 C  CG2 . THR A 1 624 ? 107.113 121.334 188.388 1.00 25.83  ? 614  THR A CG2 1 
ATOM   3638 N  N   . ILE A 1 625 ? 108.556 119.151 192.342 1.00 24.66  ? 615  ILE A N   1 
ATOM   3639 C  CA  . ILE A 1 625 ? 109.497 118.914 193.428 1.00 24.66  ? 615  ILE A CA  1 
ATOM   3640 C  C   . ILE A 1 625 ? 110.920 118.993 192.893 1.00 24.66  ? 615  ILE A C   1 
ATOM   3641 O  O   . ILE A 1 625 ? 111.257 118.383 191.870 1.00 24.66  ? 615  ILE A O   1 
ATOM   3642 C  CB  . ILE A 1 625 ? 109.207 117.567 194.111 1.00 24.66  ? 615  ILE A CB  1 
ATOM   3643 C  CG1 . ILE A 1 625 ? 110.254 117.268 195.186 1.00 24.66  ? 615  ILE A CG1 1 
ATOM   3644 C  CG2 . ILE A 1 625 ? 109.076 116.436 193.093 1.00 24.66  ? 615  ILE A CG2 1 
ATOM   3645 C  CD1 . ILE A 1 625 ? 109.867 116.140 196.114 1.00 24.66  ? 615  ILE A CD1 1 
ATOM   3646 N  N   . THR A 1 626 ? 111.757 119.774 193.568 1.00 22.73  ? 616  THR A N   1 
ATOM   3647 C  CA  . THR A 1 626 ? 113.155 119.929 193.206 1.00 22.73  ? 616  THR A CA  1 
ATOM   3648 C  C   . THR A 1 626 ? 114.013 119.190 194.225 1.00 22.73  ? 616  THR A C   1 
ATOM   3649 O  O   . THR A 1 626 ? 113.644 119.066 195.396 1.00 22.73  ? 616  THR A O   1 
ATOM   3650 C  CB  . THR A 1 626 ? 113.547 121.411 193.147 1.00 22.73  ? 616  THR A CB  1 
ATOM   3651 O  OG1 . THR A 1 626 ? 112.510 122.150 192.492 1.00 22.73  ? 616  THR A OG1 1 
ATOM   3652 C  CG2 . THR A 1 626 ? 114.832 121.603 192.360 1.00 22.73  ? 616  THR A CG2 1 
ATOM   3653 N  N   . GLY A 1 627 ? 115.161 118.687 193.766 1.00 27.67  ? 617  GLY A N   1 
ATOM   3654 C  CA  . GLY A 1 627 ? 116.028 117.899 194.625 1.00 27.67  ? 617  GLY A CA  1 
ATOM   3655 C  C   . GLY A 1 627 ? 116.725 118.692 195.710 1.00 27.67  ? 617  GLY A C   1 
ATOM   3656 O  O   . GLY A 1 627 ? 117.236 118.094 196.662 1.00 27.67  ? 617  GLY A O   1 
ATOM   3657 N  N   . LYS A 1 628 ? 116.766 120.017 195.583 1.00 28.38  ? 618  LYS A N   1 
ATOM   3658 C  CA  . LYS A 1 628 ? 117.458 120.846 196.561 1.00 28.38  ? 618  LYS A CA  1 
ATOM   3659 C  C   . LYS A 1 628 ? 116.766 120.785 197.916 1.00 28.38  ? 618  LYS A C   1 
ATOM   3660 O  O   . LYS A 1 628 ? 115.536 120.785 198.008 1.00 28.38  ? 618  LYS A O   1 
ATOM   3661 C  CB  . LYS A 1 628 ? 117.525 122.293 196.074 1.00 28.38  ? 618  LYS A CB  1 
ATOM   3662 C  CG  . LYS A 1 628 ? 118.431 122.503 194.876 1.00 28.38  ? 618  LYS A CG  1 
ATOM   3663 C  CD  . LYS A 1 628 ? 118.422 123.952 194.422 1.00 28.38  ? 618  LYS A CD  1 
ATOM   3664 C  CE  . LYS A 1 628 ? 117.017 124.418 194.089 1.00 28.38  ? 618  LYS A CE  1 
ATOM   3665 N  NZ  . LYS A 1 628 ? 117.024 125.699 193.332 1.00 28.38  ? 618  LYS A NZ  1 
ATOM   3666 N  N   . TYR A 1 629 ? 117.569 120.727 198.973 1.00 35.62  ? 619  TYR A N   1 
ATOM   3667 C  CA  . TYR A 1 629 ? 117.083 120.724 200.345 1.00 35.62  ? 619  TYR A CA  1 
ATOM   3668 C  C   . TYR A 1 629 ? 117.469 122.028 201.026 1.00 35.62  ? 619  TYR A C   1 
ATOM   3669 O  O   . TYR A 1 629 ? 118.643 122.411 201.025 1.00 35.62  ? 619  TYR A O   1 
ATOM   3670 C  CB  . TYR A 1 629 ? 117.650 119.540 201.132 1.00 35.62  ? 619  TYR A CB  1 
ATOM   3671 C  CG  . TYR A 1 629 ? 116.789 118.301 201.105 1.00 35.62  ? 619  TYR A CG  1 
ATOM   3672 C  CD1 . TYR A 1 629 ? 116.177 117.879 199.935 1.00 35.62  ? 619  TYR A CD1 1 
ATOM   3673 C  CD2 . TYR A 1 629 ? 116.584 117.557 202.258 1.00 35.62  ? 619  TYR A CD2 1 
ATOM   3674 C  CE1 . TYR A 1 629 ? 115.387 116.746 199.913 1.00 35.62  ? 619  TYR A CE1 1 
ATOM   3675 C  CE2 . TYR A 1 629 ? 115.797 116.426 202.247 1.00 35.62  ? 619  TYR A CE2 1 
ATOM   3676 C  CZ  . TYR A 1 629 ? 115.200 116.024 201.073 1.00 35.62  ? 619  TYR A CZ  1 
ATOM   3677 O  OH  . TYR A 1 629 ? 114.414 114.895 201.060 1.00 35.62  ? 619  TYR A OH  1 
ATOM   3678 N  N   . LEU A 1 630 ? 116.480 122.705 201.601 1.00 35.22  ? 620  LEU A N   1 
ATOM   3679 C  CA  . LEU A 1 630 ? 116.695 123.902 202.403 1.00 35.22  ? 620  LEU A CA  1 
ATOM   3680 C  C   . LEU A 1 630 ? 116.087 123.672 203.778 1.00 35.22  ? 620  LEU A C   1 
ATOM   3681 O  O   . LEU A 1 630 ? 114.896 123.360 203.885 1.00 35.22  ? 620  LEU A O   1 
ATOM   3682 C  CB  . LEU A 1 630 ? 116.082 125.139 201.742 1.00 35.22  ? 620  LEU A CB  1 
ATOM   3683 C  CG  . LEU A 1 630 ? 116.962 125.993 200.823 1.00 35.22  ? 620  LEU A CG  1 
ATOM   3684 C  CD1 . LEU A 1 630 ? 118.126 126.582 201.601 1.00 35.22  ? 620  LEU A CD1 1 
ATOM   3685 C  CD2 . LEU A 1 630 ? 117.463 125.220 199.614 1.00 35.22  ? 620  LEU A CD2 1 
ATOM   3686 N  N   . PHE A 1 631 ? 116.913 123.810 204.818 1.00 36.59  ? 621  PHE A N   1 
ATOM   3687 C  CA  . PHE A 1 631 ? 116.511 123.701 206.222 1.00 36.59  ? 621  PHE A CA  1 
ATOM   3688 C  C   . PHE A 1 631 ? 115.934 122.331 206.564 1.00 36.59  ? 621  PHE A C   1 
ATOM   3689 O  O   . PHE A 1 631 ? 115.167 122.202 207.523 1.00 36.59  ? 621  PHE A O   1 
ATOM   3690 C  CB  . PHE A 1 631 ? 115.510 124.799 206.614 1.00 36.59  ? 621  PHE A CB  1 
ATOM   3691 C  CG  . PHE A 1 631 ? 115.892 126.178 206.144 1.00 36.59  ? 621  PHE A CG  1 
ATOM   3692 C  CD1 . PHE A 1 631 ? 117.212 126.601 206.163 1.00 36.59  ? 621  PHE A CD1 1 
ATOM   3693 C  CD2 . PHE A 1 631 ? 114.925 127.049 205.677 1.00 36.59  ? 621  PHE A CD2 1 
ATOM   3694 C  CE1 . PHE A 1 631 ? 117.555 127.865 205.729 1.00 36.59  ? 621  PHE A CE1 1 
ATOM   3695 C  CE2 . PHE A 1 631 ? 115.263 128.313 205.241 1.00 36.59  ? 621  PHE A CE2 1 
ATOM   3696 C  CZ  . PHE A 1 631 ? 116.579 128.721 205.267 1.00 36.59  ? 621  PHE A CZ  1 
ATOM   3697 N  N   . GLY A 1 632 ? 116.292 121.299 205.803 1.00 34.06  ? 622  GLY A N   1 
ATOM   3698 C  CA  . GLY A 1 632 ? 115.771 119.968 206.038 1.00 34.06  ? 622  GLY A CA  1 
ATOM   3699 C  C   . GLY A 1 632 ? 114.434 119.670 205.399 1.00 34.06  ? 622  GLY A C   1 
ATOM   3700 O  O   . GLY A 1 632 ? 113.838 118.632 205.709 1.00 34.06  ? 622  GLY A O   1 
ATOM   3701 N  N   . GLN A 1 633 ? 113.941 120.538 204.522 1.00 33.14  ? 623  GLN A N   1 
ATOM   3702 C  CA  . GLN A 1 633 ? 112.674 120.343 203.839 1.00 33.14  ? 623  GLN A CA  1 
ATOM   3703 C  C   . GLN A 1 633 ? 112.873 120.477 202.338 1.00 33.14  ? 623  GLN A C   1 
ATOM   3704 O  O   . GLN A 1 633 ? 113.729 121.246 201.890 1.00 33.14  ? 623  GLN A O   1 
ATOM   3705 C  CB  . GLN A 1 633 ? 111.627 121.363 204.309 1.00 33.14  ? 623  GLN A CB  1 
ATOM   3706 C  CG  . GLN A 1 633 ? 111.447 121.425 205.814 1.00 33.14  ? 623  GLN A CG  1 
ATOM   3707 C  CD  . GLN A 1 633 ? 110.954 120.117 206.391 1.00 33.14  ? 623  GLN A CD  1 
ATOM   3708 O  OE1 . GLN A 1 633 ? 111.571 119.551 207.292 1.00 33.14  ? 623  GLN A OE1 1 
ATOM   3709 N  NE2 . GLN A 1 633 ? 109.833 119.630 205.876 1.00 33.14  ? 623  GLN A NE2 1 
ATOM   3710 N  N   . PRO A 1 634 ? 112.107 119.737 201.538 1.00 28.44  ? 624  PRO A N   1 
ATOM   3711 C  CA  . PRO A 1 634 ? 112.231 119.863 200.083 1.00 28.44  ? 624  PRO A CA  1 
ATOM   3712 C  C   . PRO A 1 634 ? 111.719 121.208 199.600 1.00 28.44  ? 624  PRO A C   1 
ATOM   3713 O  O   . PRO A 1 634 ? 110.865 121.836 200.228 1.00 28.44  ? 624  PRO A O   1 
ATOM   3714 C  CB  . PRO A 1 634 ? 111.367 118.715 199.547 1.00 28.44  ? 624  PRO A CB  1 
ATOM   3715 C  CG  . PRO A 1 634 ? 111.122 117.815 200.720 1.00 28.44  ? 624  PRO A CG  1 
ATOM   3716 C  CD  . PRO A 1 634 ? 111.136 118.700 201.917 1.00 28.44  ? 624  PRO A CD  1 
ATOM   3717 N  N   . VAL A 1 635 ? 112.257 121.650 198.470 1.00 23.38  ? 625  VAL A N   1 
ATOM   3718 C  CA  . VAL A 1 635 ? 111.912 122.937 197.881 1.00 23.38  ? 625  VAL A CA  1 
ATOM   3719 C  C   . VAL A 1 635 ? 111.060 122.669 196.648 1.00 23.38  ? 625  VAL A C   1 
ATOM   3720 O  O   . VAL A 1 635 ? 111.545 122.116 195.654 1.00 23.38  ? 625  VAL A O   1 
ATOM   3721 C  CB  . VAL A 1 635 ? 113.163 123.754 197.532 1.00 23.38  ? 625  VAL A CB  1 
ATOM   3722 C  CG1 . VAL A 1 635 ? 112.814 124.898 196.603 1.00 23.38  ? 625  VAL A CG1 1 
ATOM   3723 C  CG2 . VAL A 1 635 ? 113.808 124.284 198.794 1.00 23.38  ? 625  VAL A CG2 1 
ATOM   3724 N  N   . PHE A 1 636 ? 109.785 123.040 196.715 1.00 23.96  ? 626  PHE A N   1 
ATOM   3725 C  CA  . PHE A 1 636 ? 108.879 122.929 195.585 1.00 23.96  ? 626  PHE A CA  1 
ATOM   3726 C  C   . PHE A 1 636 ? 108.910 124.217 194.777 1.00 23.96  ? 626  PHE A C   1 
ATOM   3727 O  O   . PHE A 1 636 ? 109.146 125.300 195.317 1.00 23.96  ? 626  PHE A O   1 
ATOM   3728 C  CB  . PHE A 1 636 ? 107.457 122.650 196.065 1.00 23.96  ? 626  PHE A CB  1 
ATOM   3729 C  CG  . PHE A 1 636 ? 107.313 121.361 196.814 1.00 23.96  ? 626  PHE A CG  1 
ATOM   3730 C  CD1 . PHE A 1 636 ? 108.147 120.292 196.556 1.00 23.96  ? 626  PHE A CD1 1 
ATOM   3731 C  CD2 . PHE A 1 636 ? 106.350 121.226 197.793 1.00 23.96  ? 626  PHE A CD2 1 
ATOM   3732 C  CE1 . PHE A 1 636 ? 108.010 119.109 197.250 1.00 23.96  ? 626  PHE A CE1 1 
ATOM   3733 C  CE2 . PHE A 1 636 ? 106.210 120.048 198.491 1.00 23.96  ? 626  PHE A CE2 1 
ATOM   3734 C  CZ  . PHE A 1 636 ? 107.041 118.988 198.220 1.00 23.96  ? 626  PHE A CZ  1 
ATOM   3735 N  N   . ARG A 1 637 ? 108.664 124.099 193.474 1.00 26.82  ? 627  ARG A N   1 
ATOM   3736 C  CA  . ARG A 1 637 ? 108.695 125.248 192.579 1.00 26.82  ? 627  ARG A CA  1 
ATOM   3737 C  C   . ARG A 1 637 ? 107.383 125.341 191.817 1.00 26.82  ? 627  ARG A C   1 
ATOM   3738 O  O   . ARG A 1 637 ? 106.919 124.343 191.260 1.00 26.82  ? 627  ARG A O   1 
ATOM   3739 C  CB  . ARG A 1 637 ? 109.865 125.147 191.598 1.00 26.82  ? 627  ARG A CB  1 
ATOM   3740 C  CG  . ARG A 1 637 ? 109.823 126.165 190.475 1.00 26.82  ? 627  ARG A CG  1 
ATOM   3741 C  CD  . ARG A 1 637 ? 110.948 125.938 189.487 1.00 26.82  ? 627  ARG A CD  1 
ATOM   3742 N  NE  . ARG A 1 637 ? 111.330 127.165 188.800 1.00 26.82  ? 627  ARG A NE  1 
ATOM   3743 C  CZ  . ARG A 1 637 ? 112.191 128.053 189.278 1.00 26.82  ? 627  ARG A CZ  1 
ATOM   3744 N  NH1 . ARG A 1 637 ? 112.781 127.880 190.448 1.00 26.82  ? 627  ARG A NH1 1 
ATOM   3745 N  NH2 . ARG A 1 637 ? 112.467 129.139 188.563 1.00 26.82  ? 627  ARG A NH2 1 
ATOM   3746 N  N   . LYS A 1 638 ? 106.787 126.531 191.794 1.00 30.84  ? 628  LYS A N   1 
ATOM   3747 C  CA  . LYS A 1 638 ? 105.610 126.753 190.965 1.00 30.84  ? 628  LYS A CA  1 
ATOM   3748 C  C   . LYS A 1 638 ? 105.995 126.703 189.494 1.00 30.84  ? 628  LYS A C   1 
ATOM   3749 O  O   . LYS A 1 638 ? 106.974 127.329 189.075 1.00 30.84  ? 628  LYS A O   1 
ATOM   3750 C  CB  . LYS A 1 638 ? 104.955 128.092 191.297 1.00 30.84  ? 628  LYS A CB  1 
ATOM   3751 C  CG  . LYS A 1 638 ? 104.062 128.047 192.518 1.00 30.84  ? 628  LYS A CG  1 
ATOM   3752 C  CD  . LYS A 1 638 ? 103.166 129.261 192.619 1.00 30.84  ? 628  LYS A CD  1 
ATOM   3753 C  CE  . LYS A 1 638 ? 103.953 130.470 193.060 1.00 30.84  ? 628  LYS A CE  1 
ATOM   3754 N  NZ  . LYS A 1 638 ? 103.087 131.654 193.297 1.00 30.84  ? 628  LYS A NZ  1 
ATOM   3755 N  N   . VAL A 1 639 ? 105.222 125.961 188.709 1.00 32.73  ? 629  VAL A N   1 
ATOM   3756 C  CA  . VAL A 1 639 ? 105.520 125.756 187.297 1.00 32.73  ? 629  VAL A CA  1 
ATOM   3757 C  C   . VAL A 1 639 ? 104.761 126.789 186.473 1.00 32.73  ? 629  VAL A C   1 
ATOM   3758 O  O   . VAL A 1 639 ? 103.540 126.929 186.595 1.00 32.73  ? 629  VAL A O   1 
ATOM   3759 C  CB  . VAL A 1 639 ? 105.187 124.319 186.860 1.00 32.73  ? 629  VAL A CB  1 
ATOM   3760 C  CG1 . VAL A 1 639 ? 103.792 123.902 187.314 1.00 32.73  ? 629  VAL A CG1 1 
ATOM   3761 C  CG2 . VAL A 1 639 ? 105.325 124.178 185.355 1.00 32.73  ? 629  VAL A CG2 1 
ATOM   3762 N  N   . HIS A 1 640 ? 105.494 127.540 185.657 1.00 46.60  ? 630  HIS A N   1 
ATOM   3763 C  CA  . HIS A 1 640 ? 104.874 128.539 184.802 1.00 46.60  ? 630  HIS A CA  1 
ATOM   3764 C  C   . HIS A 1 640 ? 104.064 127.860 183.704 1.00 46.60  ? 630  HIS A C   1 
ATOM   3765 O  O   . HIS A 1 640 ? 104.329 126.717 183.325 1.00 46.60  ? 630  HIS A O   1 
ATOM   3766 C  CB  . HIS A 1 640 ? 105.939 129.451 184.194 1.00 46.60  ? 630  HIS A CB  1 
ATOM   3767 C  CG  . HIS A 1 640 ? 105.387 130.696 183.573 1.00 46.60  ? 630  HIS A CG  1 
ATOM   3768 N  ND1 . HIS A 1 640 ? 105.353 130.897 182.210 1.00 46.60  ? 630  HIS A ND1 1 
ATOM   3769 C  CD2 . HIS A 1 640 ? 104.849 131.806 184.130 1.00 46.60  ? 630  HIS A CD2 1 
ATOM   3770 C  CE1 . HIS A 1 640 ? 104.818 132.077 181.954 1.00 46.60  ? 630  HIS A CE1 1 
ATOM   3771 N  NE2 . HIS A 1 640 ? 104.502 132.649 183.102 1.00 46.60  ? 630  HIS A NE2 1 
ATOM   3772 N  N   . ALA A 1 641 ? 103.052 128.573 183.204 1.00 50.21  ? 631  ALA A N   1 
ATOM   3773 C  CA  . ALA A 1 641 ? 102.181 127.999 182.183 1.00 50.21  ? 631  ALA A CA  1 
ATOM   3774 C  C   . ALA A 1 641 ? 102.916 127.772 180.869 1.00 50.21  ? 631  ALA A C   1 
ATOM   3775 O  O   . ALA A 1 641 ? 102.559 126.860 180.115 1.00 50.21  ? 631  ALA A O   1 
ATOM   3776 C  CB  . ALA A 1 641 ? 100.966 128.897 181.961 1.00 50.21  ? 631  ALA A CB  1 
ATOM   3777 N  N   . ARG A 1 642 ? 103.927 128.592 180.571 1.00 58.63  ? 632  ARG A N   1 
ATOM   3778 C  CA  . ARG A 1 642 ? 104.714 128.388 179.358 1.00 58.63  ? 632  ARG A CA  1 
ATOM   3779 C  C   . ARG A 1 642 ? 105.524 127.098 179.431 1.00 58.63  ? 632  ARG A C   1 
ATOM   3780 O  O   . ARG A 1 642 ? 105.588 126.343 178.454 1.00 58.63  ? 632  ARG A O   1 
ATOM   3781 C  CB  . ARG A 1 642 ? 105.627 129.591 179.121 1.00 58.63  ? 632  ARG A CB  1 
ATOM   3782 C  CG  . ARG A 1 642 ? 106.895 129.282 178.343 1.00 58.63  ? 632  ARG A CG  1 
ATOM   3783 C  CD  . ARG A 1 642 ? 107.858 130.455 178.368 1.00 58.63  ? 632  ARG A CD  1 
ATOM   3784 N  NE  . ARG A 1 642 ? 107.750 131.227 179.601 1.00 58.63  ? 632  ARG A NE  1 
ATOM   3785 C  CZ  . ARG A 1 642 ? 108.477 131.009 180.688 1.00 58.63  ? 632  ARG A CZ  1 
ATOM   3786 N  NH1 . ARG A 1 642 ? 109.379 130.042 180.733 1.00 58.63  ? 632  ARG A NH1 1 
ATOM   3787 N  NH2 . ARG A 1 642 ? 108.295 131.780 181.755 1.00 58.63  ? 632  ARG A NH2 1 
ATOM   3788 N  N   . GLU A 1 643 ? 106.142 126.827 180.578 1.00 60.00  ? 633  GLU A N   1 
ATOM   3789 C  CA  . GLU A 1 643 ? 106.930 125.613 180.738 1.00 60.00  ? 633  GLU A CA  1 
ATOM   3790 C  C   . GLU A 1 643 ? 106.027 124.387 180.752 1.00 60.00  ? 633  GLU A C   1 
ATOM   3791 O  O   . GLU A 1 643 ? 104.962 124.385 181.375 1.00 60.00  ? 633  GLU A O   1 
ATOM   3792 C  CB  . GLU A 1 643 ? 107.750 125.679 182.025 1.00 60.00  ? 633  GLU A CB  1 
ATOM   3793 C  CG  . GLU A 1 643 ? 108.790 126.786 182.031 1.00 60.00  ? 633  GLU A CG  1 
ATOM   3794 C  CD  . GLU A 1 643 ? 109.742 126.687 183.204 1.00 60.00  ? 633  GLU A CD  1 
ATOM   3795 O  OE1 . GLU A 1 643 ? 109.544 125.798 184.059 1.00 60.00  ? 633  GLU A OE1 1 
ATOM   3796 O  OE2 . GLU A 1 643 ? 110.687 127.500 183.273 1.00 60.00  ? 633  GLU A OE2 1 
ATOM   3797 N  N   . HIS A 1 644 ? 106.460 123.336 180.057 1.00 70.34  ? 634  HIS A N   1 
ATOM   3798 C  CA  . HIS A 1 644 ? 105.662 122.124 179.902 1.00 70.34  ? 634  HIS A CA  1 
ATOM   3799 C  C   . HIS A 1 644 ? 106.306 120.969 180.656 1.00 70.34  ? 634  HIS A C   1 
ATOM   3800 O  O   . HIS A 1 644 ? 107.301 120.397 180.184 1.00 70.34  ? 634  HIS A O   1 
ATOM   3801 C  CB  . HIS A 1 644 ? 105.505 121.773 178.420 1.00 70.34  ? 634  HIS A CB  1 
ATOM   3802 C  CG  . HIS A 1 644 ? 104.448 122.568 177.721 1.00 70.34  ? 634  HIS A CG  1 
ATOM   3803 N  ND1 . HIS A 1 644 ? 104.744 123.584 176.838 1.00 70.34  ? 634  HIS A ND1 1 
ATOM   3804 C  CD2 . HIS A 1 644 ? 103.097 122.498 177.775 1.00 70.34  ? 634  HIS A CD2 1 
ATOM   3805 C  CE1 . HIS A 1 644 ? 103.620 124.105 176.378 1.00 70.34  ? 634  HIS A CE1 1 
ATOM   3806 N  NE2 . HIS A 1 644 ? 102.607 123.463 176.930 1.00 70.34  ? 634  HIS A NE2 1 
ATOM   3807 N  N   . PRO A 1 645 ? 105.792 120.590 181.817 1.00 73.02  ? 635  PRO A N   1 
ATOM   3808 C  CA  . PRO A 1 645 ? 106.304 119.414 182.522 1.00 73.02  ? 635  PRO A CA  1 
ATOM   3809 C  C   . PRO A 1 645 ? 105.688 118.140 181.951 1.00 73.02  ? 635  PRO A C   1 
ATOM   3810 O  O   . PRO A 1 645 ? 104.933 118.160 180.981 1.00 73.02  ? 635  PRO A O   1 
ATOM   3811 C  CB  . PRO A 1 645 ? 105.860 119.655 183.964 1.00 73.02  ? 635  PRO A CB  1 
ATOM   3812 C  CG  . PRO A 1 645 ? 104.606 120.439 183.823 1.00 73.02  ? 635  PRO A CG  1 
ATOM   3813 C  CD  . PRO A 1 645 ? 104.783 121.313 182.610 1.00 73.02  ? 635  PRO A CD  1 
ATOM   3814 N  N   . ILE A 1 646 ? 106.031 117.016 182.583 1.00 74.34  ? 636  ILE A N   1 
ATOM   3815 C  CA  . ILE A 1 646 ? 105.499 115.722 182.174 1.00 74.34  ? 636  ILE A CA  1 
ATOM   3816 C  C   . ILE A 1 646 ? 104.016 115.603 182.519 1.00 74.34  ? 636  ILE A C   1 
ATOM   3817 O  O   . ILE A 1 646 ? 103.304 114.788 181.916 1.00 74.34  ? 636  ILE A O   1 
ATOM   3818 C  CB  . ILE A 1 646 ? 106.346 114.610 182.828 1.00 74.34  ? 636  ILE A CB  1 
ATOM   3819 C  CG1 . ILE A 1 646 ? 107.822 114.808 182.483 1.00 74.34  ? 636  ILE A CG1 1 
ATOM   3820 C  CG2 . ILE A 1 646 ? 105.941 113.224 182.347 1.00 74.34  ? 636  ILE A CG2 1 
ATOM   3821 C  CD1 . ILE A 1 646 ? 108.756 113.927 183.279 1.00 74.34  ? 636  ILE A CD1 1 
ATOM   3822 N  N   . LEU A 1 647 ? 103.534 116.424 183.456 1.00 72.96  ? 637  LEU A N   1 
ATOM   3823 C  CA  . LEU A 1 647 ? 102.199 116.438 184.059 1.00 72.96  ? 637  LEU A CA  1 
ATOM   3824 C  C   . LEU A 1 647 ? 101.960 115.239 184.967 1.00 72.96  ? 637  LEU A C   1 
ATOM   3825 O  O   . LEU A 1 647 ? 100.847 115.081 185.483 1.00 72.96  ? 637  LEU A O   1 
ATOM   3826 C  CB  . LEU A 1 647 ? 101.060 116.531 183.030 1.00 72.96  ? 637  LEU A CB  1 
ATOM   3827 C  CG  . LEU A 1 647 ? 100.926 117.873 182.307 1.00 72.96  ? 637  LEU A CG  1 
ATOM   3828 C  CD1 . LEU A 1 647 ? 99.786  117.833 181.301 1.00 72.96  ? 637  LEU A CD1 1 
ATOM   3829 C  CD2 . LEU A 1 647 ? 100.727 119.004 183.305 1.00 72.96  ? 637  LEU A CD2 1 
ATOM   3830 N  N   . SER A 1 648 ? 102.962 114.388 185.176 1.00 70.89  ? 638  SER A N   1 
ATOM   3831 C  CA  . SER A 1 648 ? 102.939 113.390 186.235 1.00 70.89  ? 638  SER A CA  1 
ATOM   3832 C  C   . SER A 1 648 ? 103.862 113.750 187.389 1.00 70.89  ? 638  SER A C   1 
ATOM   3833 O  O   . SER A 1 648 ? 103.663 113.263 188.506 1.00 70.89  ? 638  SER A O   1 
ATOM   3834 C  CB  . SER A 1 648 ? 103.333 112.016 185.682 1.00 70.89  ? 638  SER A CB  1 
ATOM   3835 O  OG  . SER A 1 648 ? 102.401 111.572 184.712 1.00 70.89  ? 638  SER A OG  1 
ATOM   3836 N  N   . THR A 1 649 ? 104.867 114.590 187.134 1.00 62.06  ? 639  THR A N   1 
ATOM   3837 C  CA  . THR A 1 649 ? 105.768 115.028 188.194 1.00 62.06  ? 639  THR A CA  1 
ATOM   3838 C  C   . THR A 1 649 ? 105.102 116.061 189.097 1.00 62.06  ? 639  THR A C   1 
ATOM   3839 O  O   . THR A 1 649 ? 105.384 116.113 190.300 1.00 62.06  ? 639  THR A O   1 
ATOM   3840 C  CB  . THR A 1 649 ? 107.051 115.598 187.586 1.00 62.06  ? 639  THR A CB  1 
ATOM   3841 O  OG1 . THR A 1 649 ? 107.478 114.763 186.502 1.00 62.06  ? 639  THR A OG1 1 
ATOM   3842 C  CG2 . THR A 1 649 ? 108.159 115.665 188.628 1.00 62.06  ? 639  THR A CG2 1 
ATOM   3843 N  N   . VAL A 1 650 ? 104.220 116.891 188.535 1.00 48.29  ? 640  VAL A N   1 
ATOM   3844 C  CA  . VAL A 1 650 ? 103.636 117.995 189.286 1.00 48.29  ? 640  VAL A CA  1 
ATOM   3845 C  C   . VAL A 1 650 ? 102.697 117.466 190.364 1.00 48.29  ? 640  VAL A C   1 
ATOM   3846 O  O   . VAL A 1 650 ? 102.006 116.455 190.180 1.00 48.29  ? 640  VAL A O   1 
ATOM   3847 C  CB  . VAL A 1 650 ? 102.915 118.970 188.338 1.00 48.29  ? 640  VAL A CB  1 
ATOM   3848 C  CG1 . VAL A 1 650 ? 103.909 119.598 187.379 1.00 48.29  ? 640  VAL A CG1 1 
ATOM   3849 C  CG2 . VAL A 1 650 ? 101.813 118.267 187.566 1.00 48.29  ? 640  VAL A CG2 1 
ATOM   3850 N  N   . ILE A 1 651 ? 102.698 118.136 191.514 1.00 40.80  ? 641  ILE A N   1 
ATOM   3851 C  CA  . ILE A 1 651 ? 101.849 117.787 192.647 1.00 40.80  ? 641  ILE A CA  1 
ATOM   3852 C  C   . ILE A 1 651 ? 101.159 119.058 193.126 1.00 40.80  ? 641  ILE A C   1 
ATOM   3853 O  O   . ILE A 1 651 ? 101.804 120.101 193.269 1.00 40.80  ? 641  ILE A O   1 
ATOM   3854 C  CB  . ILE A 1 651 ? 102.661 117.128 193.782 1.00 40.80  ? 641  ILE A CB  1 
ATOM   3855 C  CG1 . ILE A 1 651 ? 101.857 117.061 195.085 1.00 40.80  ? 641  ILE A CG1 1 
ATOM   3856 C  CG2 . ILE A 1 651 ? 103.991 117.843 193.990 1.00 40.80  ? 641  ILE A CG2 1 
ATOM   3857 C  CD1 . ILE A 1 651 ? 100.640 116.158 195.017 1.00 40.80  ? 641  ILE A CD1 1 
ATOM   3858 N  N   . THR A 1 652 ? 99.850  118.977 193.354 1.00 44.46  ? 642  THR A N   1 
ATOM   3859 C  CA  . THR A 1 652 ? 99.062  120.113 193.821 1.00 44.46  ? 642  THR A CA  1 
ATOM   3860 C  C   . THR A 1 652 ? 98.861  119.982 195.326 1.00 44.46  ? 642  THR A C   1 
ATOM   3861 O  O   . THR A 1 652 ? 98.108  119.117 195.785 1.00 44.46  ? 642  THR A O   1 
ATOM   3862 C  CB  . THR A 1 652 ? 97.720  120.181 193.096 1.00 44.46  ? 642  THR A CB  1 
ATOM   3863 O  OG1 . THR A 1 652 ? 97.943  120.335 191.689 1.00 44.46  ? 642  THR A OG1 1 
ATOM   3864 C  CG2 . THR A 1 652 ? 96.900  121.354 193.606 1.00 44.46  ? 642  THR A CG2 1 
ATOM   3865 N  N   . ILE A 1 653 ? 99.541  120.839 196.092 1.00 40.76  ? 643  ILE A N   1 
ATOM   3866 C  CA  . ILE A 1 653 ? 99.416  120.794 197.546 1.00 40.76  ? 643  ILE A CA  1 
ATOM   3867 C  C   . ILE A 1 653 ? 98.047  121.297 197.984 1.00 40.76  ? 643  ILE A C   1 
ATOM   3868 O  O   . ILE A 1 653 ? 97.399  120.693 198.848 1.00 40.76  ? 643  ILE A O   1 
ATOM   3869 C  CB  . ILE A 1 653 ? 100.545 121.599 198.208 1.00 40.76  ? 643  ILE A CB  1 
ATOM   3870 C  CG1 . ILE A 1 653 ? 101.887 121.279 197.561 1.00 40.76  ? 643  ILE A CG1 1 
ATOM   3871 C  CG2 . ILE A 1 653 ? 100.614 121.286 199.686 1.00 40.76  ? 643  ILE A CG2 1 
ATOM   3872 C  CD1 . ILE A 1 653 ? 102.987 122.190 198.022 1.00 40.76  ? 643  ILE A CD1 1 
ATOM   3873 N  N   . ALA A 1 654 ? 97.595  122.408 197.399 1.00 44.51  ? 644  ALA A N   1 
ATOM   3874 C  CA  . ALA A 1 654 ? 96.326  123.066 197.727 1.00 44.51  ? 644  ALA A CA  1 
ATOM   3875 C  C   . ALA A 1 654 ? 96.202  123.384 199.216 1.00 44.51  ? 644  ALA A C   1 
ATOM   3876 O  O   . ALA A 1 654 ? 95.536  122.666 199.961 1.00 44.51  ? 644  ALA A O   1 
ATOM   3877 C  CB  . ALA A 1 654 ? 95.142  122.215 197.264 1.00 44.51  ? 644  ALA A CB  1 
ATOM   3878 N  N   . PRO A 1 662 ? 86.965  124.684 208.559 1.00 93.18  ? 652  PRO A N   1 
ATOM   3879 C  CA  . PRO A 1 662 ? 86.832  125.191 209.927 1.00 93.18  ? 652  PRO A CA  1 
ATOM   3880 C  C   . PRO A 1 662 ? 88.180  125.491 210.579 1.00 93.18  ? 652  PRO A C   1 
ATOM   3881 O  O   . PRO A 1 662 ? 88.665  124.709 211.398 1.00 93.18  ? 652  PRO A O   1 
ATOM   3882 C  CB  . PRO A 1 662 ? 86.110  124.051 210.644 1.00 93.18  ? 652  PRO A CB  1 
ATOM   3883 C  CG  . PRO A 1 662 ? 86.569  122.816 209.930 1.00 93.18  ? 652  PRO A CG  1 
ATOM   3884 C  CD  . PRO A 1 662 ? 86.876  123.213 208.502 1.00 93.18  ? 652  PRO A CD  1 
ATOM   3885 N  N   . LEU A 1 663 ? 88.777  126.622 210.212 1.00 87.23  ? 653  LEU A N   1 
ATOM   3886 C  CA  . LEU A 1 663 ? 90.065  127.000 210.772 1.00 87.23  ? 653  LEU A CA  1 
ATOM   3887 C  C   . LEU A 1 663 ? 89.912  127.408 212.235 1.00 87.23  ? 653  LEU A C   1 
ATOM   3888 O  O   . LEU A 1 663 ? 88.864  127.896 212.664 1.00 87.23  ? 653  LEU A O   1 
ATOM   3889 C  CB  . LEU A 1 663 ? 90.689  128.132 209.958 1.00 87.23  ? 653  LEU A CB  1 
ATOM   3890 C  CG  . LEU A 1 663 ? 91.189  127.729 208.568 1.00 87.23  ? 653  LEU A CG  1 
ATOM   3891 C  CD1 . LEU A 1 663 ? 91.635  128.942 207.766 1.00 87.23  ? 653  LEU A CD1 1 
ATOM   3892 C  CD2 . LEU A 1 663 ? 92.309  126.710 208.672 1.00 87.23  ? 653  LEU A CD2 1 
ATOM   3893 N  N   . THR A 1 664 ? 90.979  127.194 213.003 1.00 90.62  ? 654  THR A N   1 
ATOM   3894 C  CA  . THR A 1 664 ? 90.934  127.306 214.455 1.00 90.62  ? 654  THR A CA  1 
ATOM   3895 C  C   . THR A 1 664 ? 90.996  128.741 214.965 1.00 90.62  ? 654  THR A C   1 
ATOM   3896 O  O   . THR A 1 664 ? 90.994  128.933 216.186 1.00 90.62  ? 654  THR A O   1 
ATOM   3897 C  CB  . THR A 1 664 ? 92.080  126.503 215.074 1.00 90.62  ? 654  THR A CB  1 
ATOM   3898 O  OG1 . THR A 1 664 ? 93.333  127.068 214.670 1.00 90.62  ? 654  THR A OG1 1 
ATOM   3899 C  CG2 . THR A 1 664 ? 92.017  125.056 214.618 1.00 90.62  ? 654  THR A CG2 1 
ATOM   3900 N  N   . SER A 1 665 ? 91.127  129.728 214.068 1.00 84.87  ? 655  SER A N   1 
ATOM   3901 C  CA  . SER A 1 665 ? 91.190  131.165 214.353 1.00 84.87  ? 655  SER A CA  1 
ATOM   3902 C  C   . SER A 1 665 ? 92.510  131.555 215.010 1.00 84.87  ? 655  SER A C   1 
ATOM   3903 O  O   . SER A 1 665 ? 92.768  132.741 215.238 1.00 84.87  ? 655  SER A O   1 
ATOM   3904 C  CB  . SER A 1 665 ? 90.007  131.631 215.212 1.00 84.87  ? 655  SER A CB  1 
ATOM   3905 O  OG  . SER A 1 665 ? 90.217  131.326 216.579 1.00 84.87  ? 655  SER A OG  1 
ATOM   3906 N  N   . LYS A 1 666 ? 93.346  130.568 215.322 1.00 78.62  ? 656  LYS A N   1 
ATOM   3907 C  CA  . LYS A 1 666 ? 94.750  130.795 215.630 1.00 78.62  ? 656  LYS A CA  1 
ATOM   3908 C  C   . LYS A 1 666 ? 95.614  130.558 214.401 1.00 78.62  ? 656  LYS A C   1 
ATOM   3909 O  O   . LYS A 1 666 ? 96.640  131.223 214.222 1.00 78.62  ? 656  LYS A O   1 
ATOM   3910 C  CB  . LYS A 1 666 ? 95.196  129.888 216.782 1.00 78.62  ? 656  LYS A CB  1 
ATOM   3911 C  CG  . LYS A 1 666 ? 96.534  130.270 217.401 1.00 78.62  ? 656  LYS A CG  1 
ATOM   3912 C  CD  . LYS A 1 666 ? 97.365  129.041 217.745 1.00 78.62  ? 656  LYS A CD  1 
ATOM   3913 C  CE  . LYS A 1 666 ? 98.702  129.430 218.362 1.00 78.62  ? 656  LYS A CE  1 
ATOM   3914 N  NZ  . LYS A 1 666 ? 99.670  129.938 217.351 1.00 78.62  ? 656  LYS A NZ  1 
ATOM   3915 N  N   . GLU A 1 667 ? 95.212  129.607 213.552 1.00 75.43  ? 657  GLU A N   1 
ATOM   3916 C  CA  . GLU A 1 667 ? 95.917  129.377 212.297 1.00 75.43  ? 657  GLU A CA  1 
ATOM   3917 C  C   . GLU A 1 667 ? 95.618  130.469 211.276 1.00 75.43  ? 657  GLU A C   1 
ATOM   3918 O  O   . GLU A 1 667 ? 96.445  130.727 210.395 1.00 75.43  ? 657  GLU A O   1 
ATOM   3919 C  CB  . GLU A 1 667 ? 95.565  127.993 211.743 1.00 75.43  ? 657  GLU A CB  1 
ATOM   3920 C  CG  . GLU A 1 667 ? 96.506  127.511 210.644 1.00 75.43  ? 657  GLU A CG  1 
ATOM   3921 C  CD  . GLU A 1 667 ? 95.958  126.332 209.868 1.00 75.43  ? 657  GLU A CD  1 
ATOM   3922 O  OE1 . GLU A 1 667 ? 94.957  125.738 210.317 1.00 75.43  ? 657  GLU A OE1 1 
ATOM   3923 O  OE2 . GLU A 1 667 ? 96.533  125.997 208.811 1.00 75.43  ? 657  GLU A OE2 1 
ATOM   3924 N  N   . GLU A 1 668 ? 94.453  131.122 211.373 1.00 77.22  ? 658  GLU A N   1 
ATOM   3925 C  CA  . GLU A 1 668 ? 94.189  132.273 210.512 1.00 77.22  ? 658  GLU A CA  1 
ATOM   3926 C  C   . GLU A 1 668 ? 95.157  133.409 210.805 1.00 77.22  ? 658  GLU A C   1 
ATOM   3927 O  O   . GLU A 1 668 ? 95.621  134.092 209.886 1.00 77.22  ? 658  GLU A O   1 
ATOM   3928 C  CB  . GLU A 1 668 ? 92.751  132.768 210.668 1.00 77.22  ? 658  GLU A CB  1 
ATOM   3929 C  CG  . GLU A 1 668 ? 91.678  131.839 210.134 1.00 77.22  ? 658  GLU A CG  1 
ATOM   3930 C  CD  . GLU A 1 668 ? 90.414  131.901 210.964 1.00 77.22  ? 658  GLU A CD  1 
ATOM   3931 O  OE1 . GLU A 1 668 ? 90.241  132.902 211.688 1.00 77.22  ? 658  GLU A OE1 1 
ATOM   3932 O  OE2 . GLU A 1 668 ? 89.586  130.971 210.887 1.00 77.22  ? 658  GLU A OE2 1 
ATOM   3933 N  N   . GLU A 1 669 ? 95.460  133.640 212.085 1.00 68.85  ? 659  GLU A N   1 
ATOM   3934 C  CA  . GLU A 1 669 ? 96.427  134.672 212.440 1.00 68.85  ? 659  GLU A CA  1 
ATOM   3935 C  C   . GLU A 1 669 ? 97.822  134.314 211.943 1.00 68.85  ? 659  GLU A C   1 
ATOM   3936 O  O   . GLU A 1 669 ? 98.569  135.188 211.487 1.00 68.85  ? 659  GLU A O   1 
ATOM   3937 C  CB  . GLU A 1 669 ? 96.429  134.889 213.952 1.00 68.85  ? 659  GLU A CB  1 
ATOM   3938 C  CG  . GLU A 1 669 ? 96.704  136.323 214.367 1.00 68.85  ? 659  GLU A CG  1 
ATOM   3939 C  CD  . GLU A 1 669 ? 95.519  137.234 214.110 1.00 68.85  ? 659  GLU A CD  1 
ATOM   3940 O  OE1 . GLU A 1 669 ? 94.387  136.721 213.989 1.00 68.85  ? 659  GLU A OE1 1 
ATOM   3941 O  OE2 . GLU A 1 669 ? 95.721  138.464 214.027 1.00 68.85  ? 659  GLU A OE2 1 
ATOM   3942 N  N   . GLU A 1 670 ? 98.188  133.032 212.022 1.00 64.24  ? 660  GLU A N   1 
ATOM   3943 C  CA  . GLU A 1 670 ? 99.471  132.589 211.487 1.00 64.24  ? 660  GLU A CA  1 
ATOM   3944 C  C   . GLU A 1 670 ? 99.537  132.789 209.978 1.00 64.24  ? 660  GLU A C   1 
ATOM   3945 O  O   . GLU A 1 670 ? 100.566 133.220 209.446 1.00 64.24  ? 660  GLU A O   1 
ATOM   3946 C  CB  . GLU A 1 670 ? 99.709  131.124 211.852 1.00 64.24  ? 660  GLU A CB  1 
ATOM   3947 C  CG  . GLU A 1 670 ? 101.148 130.663 211.700 1.00 64.24  ? 660  GLU A CG  1 
ATOM   3948 C  CD  . GLU A 1 670 ? 101.367 129.258 212.230 1.00 64.24  ? 660  GLU A CD  1 
ATOM   3949 O  OE1 . GLU A 1 670 ? 100.443 128.712 212.867 1.00 64.24  ? 660  GLU A OE1 1 
ATOM   3950 O  OE2 . GLU A 1 670 ? 102.462 128.699 212.010 1.00 64.24  ? 660  GLU A OE2 1 
ATOM   3951 N  N   . ARG A 1 671 ? 98.441  132.488 209.274 1.00 58.52  ? 661  ARG A N   1 
ATOM   3952 C  CA  . ARG A 1 671 ? 98.387  132.738 207.836 1.00 58.52  ? 661  ARG A CA  1 
ATOM   3953 C  C   . ARG A 1 671 ? 98.488  134.226 207.528 1.00 58.52  ? 661  ARG A C   1 
ATOM   3954 O  O   . ARG A 1 671 ? 99.148  134.621 206.563 1.00 58.52  ? 661  ARG A O   1 
ATOM   3955 C  CB  . ARG A 1 671 ? 97.101  132.161 207.245 1.00 58.52  ? 661  ARG A CB  1 
ATOM   3956 C  CG  . ARG A 1 671 ? 97.044  130.644 207.209 1.00 58.52  ? 661  ARG A CG  1 
ATOM   3957 C  CD  . ARG A 1 671 ? 95.819  130.164 206.446 1.00 58.52  ? 661  ARG A CD  1 
ATOM   3958 N  NE  . ARG A 1 671 ? 95.580  128.739 206.636 1.00 58.52  ? 661  ARG A NE  1 
ATOM   3959 C  CZ  . ARG A 1 671 ? 96.043  127.787 205.838 1.00 58.52  ? 661  ARG A CZ  1 
ATOM   3960 N  NH1 . ARG A 1 671 ? 96.771  128.073 204.772 1.00 58.52  ? 661  ARG A NH1 1 
ATOM   3961 N  NH2 . ARG A 1 671 ? 95.767  126.516 206.116 1.00 58.52  ? 661  ARG A NH2 1 
ATOM   3962 N  N   . ARG A 1 672 ? 97.833  135.065 208.336 1.00 56.52  ? 662  ARG A N   1 
ATOM   3963 C  CA  . ARG A 1 672 ? 97.899  136.509 208.130 1.00 56.52  ? 662  ARG A CA  1 
ATOM   3964 C  C   . ARG A 1 672 ? 99.316  137.034 208.318 1.00 56.52  ? 662  ARG A C   1 
ATOM   3965 O  O   . ARG A 1 672 ? 99.779  137.882 207.546 1.00 56.52  ? 662  ARG A O   1 
ATOM   3966 C  CB  . ARG A 1 672 ? 96.939  137.219 209.082 1.00 56.52  ? 662  ARG A CB  1 
ATOM   3967 C  CG  . ARG A 1 672 ? 96.988  138.736 208.994 1.00 56.52  ? 662  ARG A CG  1 
ATOM   3968 C  CD  . ARG A 1 672 ? 96.095  139.384 210.039 1.00 56.52  ? 662  ARG A CD  1 
ATOM   3969 N  NE  . ARG A 1 672 ? 96.604  139.193 211.392 1.00 56.52  ? 662  ARG A NE  1 
ATOM   3970 C  CZ  . ARG A 1 672 ? 97.586  139.902 211.931 1.00 56.52  ? 662  ARG A CZ  1 
ATOM   3971 N  NH1 . ARG A 1 672 ? 98.187  140.873 211.263 1.00 56.52  ? 662  ARG A NH1 1 
ATOM   3972 N  NH2 . ARG A 1 672 ? 97.973  139.632 213.175 1.00 56.52  ? 662  ARG A NH2 1 
ATOM   3973 N  N   . ILE A 1 673 ? 100.017 136.551 209.347 1.00 46.64  ? 663  ILE A N   1 
ATOM   3974 C  CA  . ILE A 1 673 ? 101.399 136.973 209.564 1.00 46.64  ? 663  ILE A CA  1 
ATOM   3975 C  C   . ILE A 1 673 ? 102.298 136.472 208.439 1.00 46.64  ? 663  ILE A C   1 
ATOM   3976 O  O   . ILE A 1 673 ? 103.152 137.212 207.936 1.00 46.64  ? 663  ILE A O   1 
ATOM   3977 C  CB  . ILE A 1 673 ? 101.898 136.506 210.943 1.00 46.64  ? 663  ILE A CB  1 
ATOM   3978 C  CG1 . ILE A 1 673 ? 101.043 137.111 212.058 1.00 46.64  ? 663  ILE A CG1 1 
ATOM   3979 C  CG2 . ILE A 1 673 ? 103.358 136.872 211.137 1.00 46.64  ? 663  ILE A CG2 1 
ATOM   3980 C  CD1 . ILE A 1 673 ? 101.346 138.563 212.353 1.00 46.64  ? 663  ILE A CD1 1 
ATOM   3981 N  N   . ALA A 1 674 ? 102.116 135.217 208.016 1.00 38.15  ? 664  ALA A N   1 
ATOM   3982 C  CA  . ALA A 1 674 ? 102.943 134.664 206.947 1.00 38.15  ? 664  ALA A CA  1 
ATOM   3983 C  C   . ALA A 1 674 ? 102.661 135.326 205.605 1.00 38.15  ? 664  ALA A C   1 
ATOM   3984 O  O   . ALA A 1 674 ? 103.529 135.330 204.726 1.00 38.15  ? 664  ALA A O   1 
ATOM   3985 C  CB  . ALA A 1 674 ? 102.728 133.156 206.843 1.00 38.15  ? 664  ALA A CB  1 
ATOM   3986 N  N   . GLU A 1 675 ? 101.458 135.876 205.426 1.00 39.67  ? 665  GLU A N   1 
ATOM   3987 C  CA  . GLU A 1 675 ? 101.110 136.517 204.163 1.00 39.67  ? 665  GLU A CA  1 
ATOM   3988 C  C   . GLU A 1 675 ? 101.862 137.826 203.970 1.00 39.67  ? 665  GLU A C   1 
ATOM   3989 O  O   . GLU A 1 675 ? 102.070 138.255 202.830 1.00 39.67  ? 665  GLU A O   1 
ATOM   3990 C  CB  . GLU A 1 675 ? 99.596  136.744 204.101 1.00 39.67  ? 665  GLU A CB  1 
ATOM   3991 C  CG  . GLU A 1 675 ? 99.049  137.276 202.774 1.00 39.67  ? 665  GLU A CG  1 
ATOM   3992 C  CD  . GLU A 1 675 ? 99.154  136.290 201.615 1.00 39.67  ? 665  GLU A CD  1 
ATOM   3993 O  OE1 . GLU A 1 675 ? 99.547  135.123 201.829 1.00 39.67  ? 665  GLU A OE1 1 
ATOM   3994 O  OE2 . GLU A 1 675 ? 98.833  136.688 200.475 1.00 39.67  ? 665  GLU A OE2 1 
ATOM   3995 N  N   . MET A 1 676 ? 102.294 138.465 205.058 1.00 34.77  ? 666  MET A N   1 
ATOM   3996 C  CA  . MET A 1 676 ? 103.116 139.665 204.947 1.00 34.77  ? 666  MET A CA  1 
ATOM   3997 C  C   . MET A 1 676 ? 104.500 139.379 204.381 1.00 34.77  ? 666  MET A C   1 
ATOM   3998 O  O   . MET A 1 676 ? 105.212 140.324 204.026 1.00 34.77  ? 666  MET A O   1 
ATOM   3999 C  CB  . MET A 1 676 ? 103.254 140.342 206.311 1.00 34.77  ? 666  MET A CB  1 
ATOM   4000 C  CG  . MET A 1 676 ? 102.025 141.112 206.756 1.00 34.77  ? 666  MET A CG  1 
ATOM   4001 S  SD  . MET A 1 676 ? 102.269 141.920 208.350 1.00 34.77  ? 666  MET A SD  1 
ATOM   4002 C  CE  . MET A 1 676 ? 100.597 141.931 208.988 1.00 34.77  ? 666  MET A CE  1 
ATOM   4003 N  N   . GLY A 1 677 ? 104.898 138.112 204.296 1.00 28.26  ? 667  GLY A N   1 
ATOM   4004 C  CA  . GLY A 1 677 ? 106.209 137.746 203.806 1.00 28.26  ? 667  GLY A CA  1 
ATOM   4005 C  C   . GLY A 1 677 ? 106.372 137.730 202.304 1.00 28.26  ? 667  GLY A C   1 
ATOM   4006 O  O   . GLY A 1 677 ? 107.493 137.526 201.834 1.00 28.26  ? 667  GLY A O   1 
ATOM   4007 N  N   . ARG A 1 678 ? 105.299 137.912 201.539 1.00 20.43  ? 668  ARG A N   1 
ATOM   4008 C  CA  . ARG A 1 678 ? 105.420 137.872 200.091 1.00 20.43  ? 668  ARG A CA  1 
ATOM   4009 C  C   . ARG A 1 678 ? 106.161 139.115 199.599 1.00 20.43  ? 668  ARG A C   1 
ATOM   4010 O  O   . ARG A 1 678 ? 106.113 140.166 200.242 1.00 20.43  ? 668  ARG A O   1 
ATOM   4011 C  CB  . ARG A 1 678 ? 104.043 137.775 199.434 1.00 20.43  ? 668  ARG A CB  1 
ATOM   4012 C  CG  . ARG A 1 678 ? 103.052 138.844 199.839 1.00 20.43  ? 668  ARG A CG  1 
ATOM   4013 C  CD  . ARG A 1 678 ? 101.801 138.780 198.969 1.00 20.43  ? 668  ARG A CD  1 
ATOM   4014 N  NE  . ARG A 1 678 ? 102.058 139.190 197.592 1.00 20.43  ? 668  ARG A NE  1 
ATOM   4015 C  CZ  . ARG A 1 678 ? 102.042 138.371 196.548 1.00 20.43  ? 668  ARG A CZ  1 
ATOM   4016 N  NH1 . ARG A 1 678 ? 101.765 137.085 196.683 1.00 20.43  ? 668  ARG A NH1 1 
ATOM   4017 N  NH2 . ARG A 1 678 ? 102.309 138.856 195.339 1.00 20.43  ? 668  ARG A NH2 1 
ATOM   4018 N  N   . PRO A 1 679 ? 106.889 139.011 198.485 1.00 17.43  ? 669  PRO A N   1 
ATOM   4019 C  CA  . PRO A 1 679 ? 107.654 140.165 197.998 1.00 17.43  ? 669  PRO A CA  1 
ATOM   4020 C  C   . PRO A 1 679 ? 106.752 141.309 197.573 1.00 17.43  ? 669  PRO A C   1 
ATOM   4021 O  O   . PRO A 1 679 ? 105.672 141.102 197.019 1.00 17.43  ? 669  PRO A O   1 
ATOM   4022 C  CB  . PRO A 1 679 ? 108.425 139.596 196.804 1.00 17.43  ? 669  PRO A CB  1 
ATOM   4023 C  CG  . PRO A 1 679 ? 107.614 138.447 196.363 1.00 17.43  ? 669  PRO A CG  1 
ATOM   4024 C  CD  . PRO A 1 679 ? 107.078 137.840 197.617 1.00 17.43  ? 669  PRO A CD  1 
ATOM   4025 N  N   . ILE A 1 680 ? 107.211 142.531 197.844 1.00 18.24  ? 670  ILE A N   1 
ATOM   4026 C  CA  . ILE A 1 680 ? 106.507 143.746 197.465 1.00 18.24  ? 670  ILE A CA  1 
ATOM   4027 C  C   . ILE A 1 680 ? 107.488 144.656 196.742 1.00 18.24  ? 670  ILE A C   1 
ATOM   4028 O  O   . ILE A 1 680 ? 108.690 144.397 196.692 1.00 18.24  ? 670  ILE A O   1 
ATOM   4029 C  CB  . ILE A 1 680 ? 105.889 144.476 198.675 1.00 18.24  ? 670  ILE A CB  1 
ATOM   4030 C  CG1 . ILE A 1 680 ? 106.983 144.987 199.607 1.00 18.24  ? 670  ILE A CG1 1 
ATOM   4031 C  CG2 . ILE A 1 680 ? 104.936 143.568 199.434 1.00 18.24  ? 670  ILE A CG2 1 
ATOM   4032 C  CD1 . ILE A 1 680 ? 106.474 145.930 200.670 1.00 18.24  ? 670  ILE A CD1 1 
ATOM   4033 N  N   . LEU A 1 681 ? 106.959 145.729 196.170 1.00 19.96  ? 671  LEU A N   1 
ATOM   4034 C  CA  . LEU A 1 681 ? 107.792 146.736 195.535 1.00 19.96  ? 671  LEU A CA  1 
ATOM   4035 C  C   . LEU A 1 681 ? 108.178 147.818 196.537 1.00 19.96  ? 671  LEU A C   1 
ATOM   4036 O  O   . LEU A 1 681 ? 107.515 148.026 197.555 1.00 19.96  ? 671  LEU A O   1 
ATOM   4037 C  CB  . LEU A 1 681 ? 107.080 147.362 194.340 1.00 19.96  ? 671  LEU A CB  1 
ATOM   4038 C  CG  . LEU A 1 681 ? 106.988 146.478 193.102 1.00 19.96  ? 671  LEU A CG  1 
ATOM   4039 C  CD1 . LEU A 1 681 ? 106.172 147.167 192.026 1.00 19.96  ? 671  LEU A CD1 1 
ATOM   4040 C  CD2 . LEU A 1 681 ? 108.378 146.149 192.601 1.00 19.96  ? 671  LEU A CD2 1 
ATOM   4041 N  N   . GLY A 1 682 ? 109.266 148.507 196.233 1.00 25.40  ? 672  GLY A N   1 
ATOM   4042 C  CA  . GLY A 1 682 ? 109.819 149.513 197.105 1.00 25.40  ? 672  GLY A CA  1 
ATOM   4043 C  C   . GLY A 1 682 ? 109.423 150.918 196.713 1.00 25.40  ? 672  GLY A C   1 
ATOM   4044 O  O   . GLY A 1 682 ? 108.361 151.151 196.126 1.00 25.40  ? 672  GLY A O   1 
ATOM   4045 N  N   . GLU A 1 683 ? 110.292 151.873 197.049 1.00 33.03  ? 673  GLU A N   1 
ATOM   4046 C  CA  . GLU A 1 683 ? 109.990 153.276 196.791 1.00 33.03  ? 673  GLU A CA  1 
ATOM   4047 C  C   . GLU A 1 683 ? 110.099 153.608 195.309 1.00 33.03  ? 673  GLU A C   1 
ATOM   4048 O  O   . GLU A 1 683 ? 109.238 154.305 194.760 1.00 33.03  ? 673  GLU A O   1 
ATOM   4049 C  CB  . GLU A 1 683 ? 110.923 154.168 197.608 1.00 33.03  ? 673  GLU A CB  1 
ATOM   4050 C  CG  . GLU A 1 683 ? 110.447 155.602 197.752 1.00 33.03  ? 673  GLU A CG  1 
ATOM   4051 C  CD  . GLU A 1 683 ? 109.412 155.764 198.848 1.00 33.03  ? 673  GLU A CD  1 
ATOM   4052 O  OE1 . GLU A 1 683 ? 109.529 155.075 199.884 1.00 33.03  ? 673  GLU A OE1 1 
ATOM   4053 O  OE2 . GLU A 1 683 ? 108.484 156.581 198.677 1.00 33.03  ? 673  GLU A OE2 1 
ATOM   4054 N  N   . HIS A 1 684 ? 111.143 153.122 194.645 1.00 30.77  ? 674  HIS A N   1 
ATOM   4055 C  CA  . HIS A 1 684 ? 111.453 153.497 193.269 1.00 30.77  ? 674  HIS A CA  1 
ATOM   4056 C  C   . HIS A 1 684 ? 111.163 152.308 192.363 1.00 30.77  ? 674  HIS A C   1 
ATOM   4057 O  O   . HIS A 1 684 ? 111.829 151.273 192.460 1.00 30.77  ? 674  HIS A O   1 
ATOM   4058 C  CB  . HIS A 1 684 ? 112.910 153.935 193.143 1.00 30.77  ? 674  HIS A CB  1 
ATOM   4059 C  CG  . HIS A 1 684 ? 113.293 155.052 194.064 1.00 30.77  ? 674  HIS A CG  1 
ATOM   4060 N  ND1 . HIS A 1 684 ? 112.366 155.807 194.748 1.00 30.77  ? 674  HIS A ND1 1 
ATOM   4061 C  CD2 . HIS A 1 684 ? 114.506 155.534 194.421 1.00 30.77  ? 674  HIS A CD2 1 
ATOM   4062 C  CE1 . HIS A 1 684 ? 112.991 156.709 195.484 1.00 30.77  ? 674  HIS A CE1 1 
ATOM   4063 N  NE2 . HIS A 1 684 ? 114.291 156.564 195.303 1.00 30.77  ? 674  HIS A NE2 1 
ATOM   4064 N  N   . THR A 1 685 ? 110.174 152.455 191.483 1.00 26.04  ? 675  THR A N   1 
ATOM   4065 C  CA  . THR A 1 685 ? 109.829 151.410 190.531 1.00 26.04  ? 675  THR A CA  1 
ATOM   4066 C  C   . THR A 1 685 ? 110.038 151.816 189.081 1.00 26.04  ? 675  THR A C   1 
ATOM   4067 O  O   . THR A 1 685 ? 110.032 150.943 188.208 1.00 26.04  ? 675  THR A O   1 
ATOM   4068 C  CB  . THR A 1 685 ? 108.369 150.974 190.714 1.00 26.04  ? 675  THR A CB  1 
ATOM   4069 O  OG1 . THR A 1 685 ? 107.498 152.058 190.375 1.00 26.04  ? 675  THR A OG1 1 
ATOM   4070 C  CG2 . THR A 1 685 ? 108.112 150.555 192.147 1.00 26.04  ? 675  THR A CG2 1 
ATOM   4071 N  N   . LYS A 1 686 ? 110.214 153.103 188.796 1.00 27.33  ? 676  LYS A N   1 
ATOM   4072 C  CA  . LYS A 1 686 ? 110.376 153.594 187.431 1.00 27.33  ? 676  LYS A CA  1 
ATOM   4073 C  C   . LYS A 1 686 ? 111.631 154.451 187.376 1.00 27.33  ? 676  LYS A C   1 
ATOM   4074 O  O   . LYS A 1 686 ? 111.678 155.525 187.983 1.00 27.33  ? 676  LYS A O   1 
ATOM   4075 C  CB  . LYS A 1 686 ? 109.151 154.393 186.989 1.00 27.33  ? 676  LYS A CB  1 
ATOM   4076 C  CG  . LYS A 1 686 ? 109.080 154.660 185.501 1.00 27.33  ? 676  LYS A CG  1 
ATOM   4077 C  CD  . LYS A 1 686 ? 107.774 155.341 185.138 1.00 27.33  ? 676  LYS A CD  1 
ATOM   4078 C  CE  . LYS A 1 686 ? 107.352 155.006 183.722 1.00 27.33  ? 676  LYS A CE  1 
ATOM   4079 N  NZ  . LYS A 1 686 ? 105.940 155.399 183.462 1.00 27.33  ? 676  LYS A NZ  1 
ATOM   4080 N  N   . LEU A 1 687 ? 112.642 153.986 186.649 1.00 27.70  ? 677  LEU A N   1 
ATOM   4081 C  CA  . LEU A 1 687 ? 113.903 154.703 186.518 1.00 27.70  ? 677  LEU A CA  1 
ATOM   4082 C  C   . LEU A 1 687 ? 113.935 155.401 185.166 1.00 27.70  ? 677  LEU A C   1 
ATOM   4083 O  O   . LEU A 1 687 ? 113.806 154.750 184.127 1.00 27.70  ? 677  LEU A O   1 
ATOM   4084 C  CB  . LEU A 1 687 ? 115.087 153.748 186.651 1.00 27.70  ? 677  LEU A CB  1 
ATOM   4085 C  CG  . LEU A 1 687 ? 116.438 154.293 186.189 1.00 27.70  ? 677  LEU A CG  1 
ATOM   4086 C  CD1 . LEU A 1 687 ? 116.837 155.503 187.003 1.00 27.70  ? 677  LEU A CD1 1 
ATOM   4087 C  CD2 . LEU A 1 687 ? 117.504 153.229 186.276 1.00 27.70  ? 677  LEU A CD2 1 
ATOM   4088 N  N   . GLU A 1 688 ? 114.116 156.716 185.181 1.00 32.86  ? 678  GLU A N   1 
ATOM   4089 C  CA  . GLU A 1 688 ? 114.216 157.505 183.961 1.00 32.86  ? 678  GLU A CA  1 
ATOM   4090 C  C   . GLU A 1 688 ? 115.688 157.693 183.620 1.00 32.86  ? 678  GLU A C   1 
ATOM   4091 O  O   . GLU A 1 688 ? 116.422 158.347 184.367 1.00 32.86  ? 678  GLU A O   1 
ATOM   4092 C  CB  . GLU A 1 688 ? 113.527 158.858 184.128 1.00 32.86  ? 678  GLU A CB  1 
ATOM   4093 C  CG  . GLU A 1 688 ? 113.865 159.857 183.039 1.00 32.86  ? 678  GLU A CG  1 
ATOM   4094 C  CD  . GLU A 1 688 ? 113.220 161.205 183.269 1.00 32.86  ? 678  GLU A CD  1 
ATOM   4095 O  OE1 . GLU A 1 688 ? 112.285 161.283 184.091 1.00 32.86  ? 678  GLU A OE1 1 
ATOM   4096 O  OE2 . GLU A 1 688 ? 113.650 162.188 182.631 1.00 32.86  ? 678  GLU A OE2 1 
ATOM   4097 N  N   . VAL A 1 689 ? 116.118 157.117 182.502 1.00 30.86  ? 679  VAL A N   1 
ATOM   4098 C  CA  . VAL A 1 689 ? 117.490 157.234 182.033 1.00 30.86  ? 679  VAL A CA  1 
ATOM   4099 C  C   . VAL A 1 689 ? 117.527 158.352 181.004 1.00 30.86  ? 679  VAL A C   1 
ATOM   4100 O  O   . VAL A 1 689 ? 116.835 158.288 179.979 1.00 30.86  ? 679  VAL A O   1 
ATOM   4101 C  CB  . VAL A 1 689 ? 117.992 155.912 181.435 1.00 30.86  ? 679  VAL A CB  1 
ATOM   4102 C  CG1 . VAL A 1 689 ? 119.255 156.142 180.630 1.00 30.86  ? 679  VAL A CG1 1 
ATOM   4103 C  CG2 . VAL A 1 689 ? 118.232 154.893 182.532 1.00 30.86  ? 679  VAL A CG2 1 
ATOM   4104 N  N   . ILE A 1 690 ? 118.322 159.378 181.282 1.00 32.41  ? 680  ILE A N   1 
ATOM   4105 C  CA  . ILE A 1 690 ? 118.452 160.546 180.420 1.00 32.41  ? 680  ILE A CA  1 
ATOM   4106 C  C   . ILE A 1 690 ? 119.762 160.408 179.662 1.00 32.41  ? 680  ILE A C   1 
ATOM   4107 O  O   . ILE A 1 690 ? 120.842 160.460 180.260 1.00 32.41  ? 680  ILE A O   1 
ATOM   4108 C  CB  . ILE A 1 690 ? 118.417 161.849 181.225 1.00 32.41  ? 680  ILE A CB  1 
ATOM   4109 C  CG1 . ILE A 1 690 ? 117.079 161.998 181.947 1.00 32.41  ? 680  ILE A CG1 1 
ATOM   4110 C  CG2 . ILE A 1 690 ? 118.670 163.037 180.320 1.00 32.41  ? 680  ILE A CG2 1 
ATOM   4111 C  CD1 . ILE A 1 690 ? 116.985 163.244 182.793 1.00 32.41  ? 680  ILE A CD1 1 
ATOM   4112 N  N   . ILE A 1 691 ? 119.680 160.236 178.350 1.00 38.64  ? 681  ILE A N   1 
ATOM   4113 C  CA  . ILE A 1 691 ? 120.880 160.078 177.539 1.00 38.64  ? 681  ILE A CA  1 
ATOM   4114 C  C   . ILE A 1 691 ? 121.453 161.452 177.219 1.00 38.64  ? 681  ILE A C   1 
ATOM   4115 O  O   . ILE A 1 691 ? 120.787 162.288 176.597 1.00 38.64  ? 681  ILE A O   1 
ATOM   4116 C  CB  . ILE A 1 691 ? 120.574 159.286 176.259 1.00 38.64  ? 681  ILE A CB  1 
ATOM   4117 C  CG1 . ILE A 1 691 ? 120.019 157.909 176.613 1.00 38.64  ? 681  ILE A CG1 1 
ATOM   4118 C  CG2 . ILE A 1 691 ? 121.820 159.149 175.413 1.00 38.64  ? 681  ILE A CG2 1 
ATOM   4119 C  CD1 . ILE A 1 691 ? 119.396 157.189 175.448 1.00 38.64  ? 681  ILE A CD1 1 
ATOM   4120 N  N   . GLU A 1 692 ? 122.693 161.682 177.634 1.00 51.24  ? 682  GLU A N   1 
ATOM   4121 C  CA  . GLU A 1 692 ? 123.417 162.915 177.367 1.00 51.24  ? 682  GLU A CA  1 
ATOM   4122 C  C   . GLU A 1 692 ? 124.514 162.640 176.351 1.00 51.24  ? 682  GLU A C   1 
ATOM   4123 O  O   . GLU A 1 692 ? 124.813 161.491 176.037 1.00 51.24  ? 682  GLU A O   1 
ATOM   4124 C  CB  . GLU A 1 692 ? 124.012 163.492 178.656 1.00 51.24  ? 682  GLU A CB  1 
ATOM   4125 C  CG  . GLU A 1 692 ? 123.012 164.221 179.529 1.00 51.24  ? 682  GLU A CG  1 
ATOM   4126 C  CD  . GLU A 1 692 ? 123.669 164.907 180.708 1.00 51.24  ? 682  GLU A CD  1 
ATOM   4127 O  OE1 . GLU A 1 692 ? 124.845 164.599 180.995 1.00 51.24  ? 682  GLU A OE1 1 
ATOM   4128 O  OE2 . GLU A 1 692 ? 123.011 165.754 181.347 1.00 51.24  ? 682  GLU A OE2 1 
ATOM   4129 N  N   . GLU A 1 693 ? 125.122 163.710 175.847 1.00 59.62  ? 683  GLU A N   1 
ATOM   4130 C  CA  . GLU A 1 693 ? 126.082 163.589 174.757 1.00 59.62  ? 683  GLU A CA  1 
ATOM   4131 C  C   . GLU A 1 693 ? 127.369 162.906 175.209 1.00 59.62  ? 683  GLU A C   1 
ATOM   4132 O  O   . GLU A 1 693 ? 127.724 162.912 176.390 1.00 59.62  ? 683  GLU A O   1 
ATOM   4133 C  CB  . GLU A 1 693 ? 126.410 164.963 174.180 1.00 59.62  ? 683  GLU A CB  1 
ATOM   4134 C  CG  . GLU A 1 693 ? 127.188 165.874 175.117 1.00 59.62  ? 683  GLU A CG  1 
ATOM   4135 C  CD  . GLU A 1 693 ? 126.292 166.684 176.034 1.00 59.62  ? 683  GLU A CD  1 
ATOM   4136 O  OE1 . GLU A 1 693 ? 125.071 166.425 176.060 1.00 59.62  ? 683  GLU A OE1 1 
ATOM   4137 O  OE2 . GLU A 1 693 ? 126.809 167.583 176.728 1.00 59.62  ? 683  GLU A OE2 1 
ATOM   4138 N  N   . SER A 1 694 ? 128.065 162.303 174.244 1.00 55.84  ? 684  SER A N   1 
ATOM   4139 C  CA  . SER A 1 694 ? 129.339 161.653 174.524 1.00 55.84  ? 684  SER A CA  1 
ATOM   4140 C  C   . SER A 1 694 ? 130.388 162.683 174.920 1.00 55.84  ? 684  SER A C   1 
ATOM   4141 O  O   . SER A 1 694 ? 130.471 163.766 174.336 1.00 55.84  ? 684  SER A O   1 
ATOM   4142 C  CB  . SER A 1 694 ? 129.810 160.863 173.304 1.00 55.84  ? 684  SER A CB  1 
ATOM   4143 O  OG  . SER A 1 694 ? 129.809 161.673 172.144 1.00 55.84  ? 684  SER A OG  1 
ATOM   4144 N  N   . TYR A 1 695 ? 131.195 162.337 175.926 1.00 62.53  ? 685  TYR A N   1 
ATOM   4145 C  CA  . TYR A 1 695 ? 132.147 163.301 176.466 1.00 62.53  ? 685  TYR A CA  1 
ATOM   4146 C  C   . TYR A 1 695 ? 133.348 163.491 175.547 1.00 62.53  ? 685  TYR A C   1 
ATOM   4147 O  O   . TYR A 1 695 ? 133.878 164.604 175.450 1.00 62.53  ? 685  TYR A O   1 
ATOM   4148 C  CB  . TYR A 1 695 ? 132.607 162.859 177.856 1.00 62.53  ? 685  TYR A CB  1 
ATOM   4149 C  CG  . TYR A 1 695 ? 133.666 163.748 178.468 1.00 62.53  ? 685  TYR A CG  1 
ATOM   4150 C  CD1 . TYR A 1 695 ? 133.500 165.127 178.517 1.00 62.53  ? 685  TYR A CD1 1 
ATOM   4151 C  CD2 . TYR A 1 695 ? 134.830 163.210 179.000 1.00 62.53  ? 685  TYR A CD2 1 
ATOM   4152 C  CE1 . TYR A 1 695 ? 134.463 165.944 179.075 1.00 62.53  ? 685  TYR A CE1 1 
ATOM   4153 C  CE2 . TYR A 1 695 ? 135.800 164.020 179.561 1.00 62.53  ? 685  TYR A CE2 1 
ATOM   4154 C  CZ  . TYR A 1 695 ? 135.611 165.386 179.596 1.00 62.53  ? 685  TYR A CZ  1 
ATOM   4155 O  OH  . TYR A 1 695 ? 136.573 166.197 180.154 1.00 62.53  ? 685  TYR A OH  1 
ATOM   4156 N  N   . GLU A 1 696 ? 133.790 162.426 174.872 1.00 58.08  ? 686  GLU A N   1 
ATOM   4157 C  CA  . GLU A 1 696 ? 134.961 162.519 174.004 1.00 58.08  ? 686  GLU A CA  1 
ATOM   4158 C  C   . GLU A 1 696 ? 134.715 163.473 172.843 1.00 58.08  ? 686  GLU A C   1 
ATOM   4159 O  O   . GLU A 1 696 ? 135.542 164.346 172.556 1.00 58.08  ? 686  GLU A O   1 
ATOM   4160 C  CB  . GLU A 1 696 ? 135.337 161.131 173.482 1.00 58.08  ? 686  GLU A CB  1 
ATOM   4161 C  CG  . GLU A 1 696 ? 135.842 160.159 174.539 1.00 58.08  ? 686  GLU A CG  1 
ATOM   4162 C  CD  . GLU A 1 696 ? 137.234 160.490 175.054 1.00 58.08  ? 686  GLU A CD  1 
ATOM   4163 O  OE1 . GLU A 1 696 ? 137.895 161.392 174.496 1.00 58.08  ? 686  GLU A OE1 1 
ATOM   4164 O  OE2 . GLU A 1 696 ? 137.672 159.838 176.025 1.00 58.08  ? 686  GLU A OE2 1 
ATOM   4165 N  N   . PHE A 1 697 ? 133.575 163.322 172.167 1.00 50.33  ? 687  PHE A N   1 
ATOM   4166 C  CA  . PHE A 1 697 ? 133.255 164.184 171.035 1.00 50.33  ? 687  PHE A CA  1 
ATOM   4167 C  C   . PHE A 1 697 ? 133.057 165.629 171.476 1.00 50.33  ? 687  PHE A C   1 
ATOM   4168 O  O   . PHE A 1 697 ? 133.510 166.556 170.794 1.00 50.33  ? 687  PHE A O   1 
ATOM   4169 C  CB  . PHE A 1 697 ? 132.013 163.656 170.320 1.00 50.33  ? 687  PHE A CB  1 
ATOM   4170 C  CG  . PHE A 1 697 ? 131.868 164.145 168.909 1.00 50.33  ? 687  PHE A CG  1 
ATOM   4171 C  CD1 . PHE A 1 697 ? 131.257 165.354 168.637 1.00 50.33  ? 687  PHE A CD1 1 
ATOM   4172 C  CD2 . PHE A 1 697 ? 132.355 163.396 167.855 1.00 50.33  ? 687  PHE A CD2 1 
ATOM   4173 C  CE1 . PHE A 1 697 ? 131.121 165.797 167.339 1.00 50.33  ? 687  PHE A CE1 1 
ATOM   4174 C  CE2 . PHE A 1 697 ? 132.227 163.840 166.557 1.00 50.33  ? 687  PHE A CE2 1 
ATOM   4175 C  CZ  . PHE A 1 697 ? 131.612 165.042 166.299 1.00 50.33  ? 687  PHE A CZ  1 
ATOM   4176 N  N   . LYS A 1 698 ? 132.386 165.836 172.611 1.00 52.08  ? 688  LYS A N   1 
ATOM   4177 C  CA  . LYS A 1 698 ? 132.184 167.188 173.124 1.00 52.08  ? 688  LYS A CA  1 
ATOM   4178 C  C   . LYS A 1 698 ? 133.511 167.859 173.450 1.00 52.08  ? 688  LYS A C   1 
ATOM   4179 O  O   . LYS A 1 698 ? 133.737 169.021 173.090 1.00 52.08  ? 688  LYS A O   1 
ATOM   4180 C  CB  . LYS A 1 698 ? 131.290 167.149 174.363 1.00 52.08  ? 688  LYS A CB  1 
ATOM   4181 C  CG  . LYS A 1 698 ? 131.013 168.514 174.967 1.00 52.08  ? 688  LYS A CG  1 
ATOM   4182 C  CD  . LYS A 1 698 ? 130.013 168.418 176.107 1.00 52.08  ? 688  LYS A CD  1 
ATOM   4183 C  CE  . LYS A 1 698 ? 129.847 169.754 176.809 1.00 52.08  ? 688  LYS A CE  1 
ATOM   4184 N  NZ  . LYS A 1 698 ? 129.208 170.768 175.927 1.00 52.08  ? 688  LYS A NZ  1 
ATOM   4185 N  N   . SER A 1 699 ? 134.409 167.134 174.123 1.00 52.58  ? 689  SER A N   1 
ATOM   4186 C  CA  . SER A 1 699 ? 135.710 167.697 174.468 1.00 52.58  ? 689  SER A CA  1 
ATOM   4187 C  C   . SER A 1 699 ? 136.540 167.981 173.223 1.00 52.58  ? 689  SER A C   1 
ATOM   4188 O  O   . SER A 1 699 ? 137.204 169.021 173.137 1.00 52.58  ? 689  SER A O   1 
ATOM   4189 C  CB  . SER A 1 699 ? 136.458 166.753 175.407 1.00 52.58  ? 689  SER A CB  1 
ATOM   4190 O  OG  . SER A 1 699 ? 137.713 167.295 175.779 1.00 52.58  ? 689  SER A OG  1 
ATOM   4191 N  N   . THR A 1 700 ? 136.508 167.070 172.245 1.00 46.05  ? 690  THR A N   1 
ATOM   4192 C  CA  . THR A 1 700 ? 137.264 167.270 171.013 1.00 46.05  ? 690  THR A CA  1 
ATOM   4193 C  C   . THR A 1 700 ? 136.763 168.487 170.245 1.00 46.05  ? 690  THR A C   1 
ATOM   4194 O  O   . THR A 1 700 ? 137.563 169.302 169.773 1.00 46.05  ? 690  THR A O   1 
ATOM   4195 C  CB  . THR A 1 700 ? 137.189 166.013 170.146 1.00 46.05  ? 690  THR A CB  1 
ATOM   4196 O  OG1 . THR A 1 700 ? 137.944 164.964 170.764 1.00 46.05  ? 690  THR A OG1 1 
ATOM   4197 C  CG2 . THR A 1 700 ? 137.751 166.272 168.760 1.00 46.05  ? 690  THR A CG2 1 
ATOM   4198 N  N   . VAL A 1 701 ? 135.442 168.647 170.136 1.00 46.61  ? 691  VAL A N   1 
ATOM   4199 C  CA  . VAL A 1 701 ? 134.897 169.789 169.408 1.00 46.61  ? 691  VAL A CA  1 
ATOM   4200 C  C   . VAL A 1 701 ? 135.161 171.089 170.159 1.00 46.61  ? 691  VAL A C   1 
ATOM   4201 O  O   . VAL A 1 701 ? 135.475 172.116 169.547 1.00 46.61  ? 691  VAL A O   1 
ATOM   4202 C  CB  . VAL A 1 701 ? 133.400 169.575 169.125 1.00 46.61  ? 691  VAL A CB  1 
ATOM   4203 C  CG1 . VAL A 1 701 ? 132.757 170.843 168.596 1.00 46.61  ? 691  VAL A CG1 1 
ATOM   4204 C  CG2 . VAL A 1 701 ? 133.232 168.468 168.116 1.00 46.61  ? 691  VAL A CG2 1 
ATOM   4205 N  N   . ASP A 1 702 ? 135.055 171.069 171.492 1.00 54.37  ? 692  ASP A N   1 
ATOM   4206 C  CA  . ASP A 1 702 ? 135.358 172.268 172.269 1.00 54.37  ? 692  ASP A CA  1 
ATOM   4207 C  C   . ASP A 1 702 ? 136.815 172.683 172.103 1.00 54.37  ? 692  ASP A C   1 
ATOM   4208 O  O   . ASP A 1 702 ? 137.113 173.868 171.910 1.00 54.37  ? 692  ASP A O   1 
ATOM   4209 C  CB  . ASP A 1 702 ? 135.031 172.034 173.744 1.00 54.37  ? 692  ASP A CB  1 
ATOM   4210 C  CG  . ASP A 1 702 ? 133.545 172.110 174.030 1.00 54.37  ? 692  ASP A CG  1 
ATOM   4211 O  OD1 . ASP A 1 702 ? 132.861 172.955 173.415 1.00 54.37  ? 692  ASP A OD1 1 
ATOM   4212 O  OD2 . ASP A 1 702 ? 133.060 171.325 174.871 1.00 54.37  ? 692  ASP A OD2 1 
ATOM   4213 N  N   . LYS A 1 703 ? 137.734 171.715 172.148 1.00 52.79  ? 693  LYS A N   1 
ATOM   4214 C  CA  . LYS A 1 703 ? 139.148 172.017 171.947 1.00 52.79  ? 693  LYS A CA  1 
ATOM   4215 C  C   . LYS A 1 703 ? 139.416 172.506 170.528 1.00 52.79  ? 693  LYS A C   1 
ATOM   4216 O  O   . LYS A 1 703 ? 140.239 173.405 170.321 1.00 52.79  ? 693  LYS A O   1 
ATOM   4217 C  CB  . LYS A 1 703 ? 139.991 170.783 172.259 1.00 52.79  ? 693  LYS A CB  1 
ATOM   4218 C  CG  . LYS A 1 703 ? 141.396 171.087 172.747 1.00 52.79  ? 693  LYS A CG  1 
ATOM   4219 C  CD  . LYS A 1 703 ? 142.075 169.832 173.273 1.00 52.79  ? 693  LYS A CD  1 
ATOM   4220 C  CE  . LYS A 1 703 ? 141.183 169.086 174.254 1.00 52.79  ? 693  LYS A CE  1 
ATOM   4221 N  NZ  . LYS A 1 703 ? 141.762 167.773 174.648 1.00 52.79  ? 693  LYS A NZ  1 
ATOM   4222 N  N   . LEU A 1 704 ? 138.737 171.919 169.538 1.00 49.60  ? 694  LEU A N   1 
ATOM   4223 C  CA  . LEU A 1 704 ? 138.924 172.335 168.152 1.00 49.60  ? 694  LEU A CA  1 
ATOM   4224 C  C   . LEU A 1 704 ? 138.438 173.761 167.928 1.00 49.60  ? 694  LEU A C   1 
ATOM   4225 O  O   . LEU A 1 704 ? 139.083 174.537 167.216 1.00 49.60  ? 694  LEU A O   1 
ATOM   4226 C  CB  . LEU A 1 704 ? 138.201 171.361 167.222 1.00 49.60  ? 694  LEU A CB  1 
ATOM   4227 C  CG  . LEU A 1 704 ? 138.429 171.474 165.715 1.00 49.60  ? 694  LEU A CG  1 
ATOM   4228 C  CD1 . LEU A 1 704 ? 138.603 170.090 165.120 1.00 49.60  ? 694  LEU A CD1 1 
ATOM   4229 C  CD2 . LEU A 1 704 ? 137.269 172.194 165.044 1.00 49.60  ? 694  LEU A CD2 1 
ATOM   4230 N  N   . ILE A 1 705 ? 137.297 174.121 168.519 1.00 52.83  ? 695  ILE A N   1 
ATOM   4231 C  CA  . ILE A 1 705 ? 136.791 175.485 168.386 1.00 52.83  ? 695  ILE A CA  1 
ATOM   4232 C  C   . ILE A 1 705 ? 137.687 176.464 169.137 1.00 52.83  ? 695  ILE A C   1 
ATOM   4233 O  O   . ILE A 1 705 ? 137.923 177.587 168.676 1.00 52.83  ? 695  ILE A O   1 
ATOM   4234 C  CB  . ILE A 1 705 ? 135.326 175.560 168.859 1.00 52.83  ? 695  ILE A CB  1 
ATOM   4235 C  CG1 . ILE A 1 705 ? 134.440 174.692 167.965 1.00 52.83  ? 695  ILE A CG1 1 
ATOM   4236 C  CG2 . ILE A 1 705 ? 134.816 176.992 168.851 1.00 52.83  ? 695  ILE A CG2 1 
ATOM   4237 C  CD1 . ILE A 1 705 ? 134.502 175.066 166.500 1.00 52.83  ? 695  ILE A CD1 1 
ATOM   4238 N  N   . LYS A 1 706 ? 138.207 176.053 170.298 1.00 61.85  ? 696  LYS A N   1 
ATOM   4239 C  CA  . LYS A 1 706 ? 139.132 176.907 171.038 1.00 61.85  ? 696  LYS A CA  1 
ATOM   4240 C  C   . LYS A 1 706 ? 140.412 177.159 170.249 1.00 61.85  ? 696  LYS A C   1 
ATOM   4241 O  O   . LYS A 1 706 ? 140.912 178.289 170.205 1.00 61.85  ? 696  LYS A O   1 
ATOM   4242 C  CB  . LYS A 1 706 ? 139.457 176.274 172.391 1.00 61.85  ? 696  LYS A CB  1 
ATOM   4243 C  CG  . LYS A 1 706 ? 140.377 177.109 173.263 1.00 61.85  ? 696  LYS A CG  1 
ATOM   4244 C  CD  . LYS A 1 706 ? 141.213 176.229 174.176 1.00 61.85  ? 696  LYS A CD  1 
ATOM   4245 C  CE  . LYS A 1 706 ? 142.313 175.524 173.398 1.00 61.85  ? 696  LYS A CE  1 
ATOM   4246 N  NZ  . LYS A 1 706 ? 142.626 174.182 173.960 1.00 61.85  ? 696  LYS A NZ  1 
ATOM   4247 N  N   . LYS A 1 707 ? 140.952 176.121 169.612 1.00 60.53  ? 697  LYS A N   1 
ATOM   4248 C  CA  . LYS A 1 707 ? 142.200 176.238 168.872 1.00 60.53  ? 697  LYS A CA  1 
ATOM   4249 C  C   . LYS A 1 707 ? 141.995 176.733 167.444 1.00 60.53  ? 697  LYS A C   1 
ATOM   4250 O  O   . LYS A 1 707 ? 142.956 177.211 166.829 1.00 60.53  ? 697  LYS A O   1 
ATOM   4251 C  CB  . LYS A 1 707 ? 142.919 174.881 168.869 1.00 60.53  ? 697  LYS A CB  1 
ATOM   4252 C  CG  . LYS A 1 707 ? 144.366 174.896 168.386 1.00 60.53  ? 697  LYS A CG  1 
ATOM   4253 C  CD  . LYS A 1 707 ? 144.999 173.512 168.452 1.00 60.53  ? 697  LYS A CD  1 
ATOM   4254 C  CE  . LYS A 1 707 ? 144.110 172.443 167.831 1.00 60.53  ? 697  LYS A CE  1 
ATOM   4255 N  NZ  . LYS A 1 707 ? 143.748 172.755 166.420 1.00 60.53  ? 697  LYS A NZ  1 
ATOM   4256 N  N   . THR A 1 708 ? 140.759 176.669 166.940 1.00 59.19  ? 698  THR A N   1 
ATOM   4257 C  CA  . THR A 1 708 ? 140.351 177.029 165.569 1.00 59.19  ? 698  THR A CA  1 
ATOM   4258 C  C   . THR A 1 708 ? 141.353 176.627 164.488 1.00 59.19  ? 698  THR A C   1 
ATOM   4259 O  O   . THR A 1 708 ? 141.484 175.448 164.161 1.00 59.19  ? 698  THR A O   1 
ATOM   4260 C  CB  . THR A 1 708 ? 140.056 178.550 165.436 1.00 59.19  ? 698  THR A CB  1 
ATOM   4261 O  OG1 . THR A 1 708 ? 139.173 178.765 164.329 1.00 59.19  ? 698  THR A OG1 1 
ATOM   4262 C  CG2 . THR A 1 708 ? 141.327 179.348 165.192 1.00 59.19  ? 698  THR A CG2 1 
ATOM   4263 N  N   . ASN A 1 717 ? 136.619 182.031 146.880 1.00 73.31  ? 707  ASN A N   1 
ATOM   4264 C  CA  . ASN A 1 717 ? 136.800 182.101 148.325 1.00 73.31  ? 707  ASN A CA  1 
ATOM   4265 C  C   . ASN A 1 717 ? 137.957 181.207 148.753 1.00 73.31  ? 707  ASN A C   1 
ATOM   4266 O  O   . ASN A 1 717 ? 139.034 181.698 149.087 1.00 73.31  ? 707  ASN A O   1 
ATOM   4267 C  CB  . ASN A 1 717 ? 135.505 181.705 149.047 1.00 73.31  ? 707  ASN A CB  1 
ATOM   4268 C  CG  . ASN A 1 717 ? 135.656 181.662 150.562 1.00 73.31  ? 707  ASN A CG  1 
ATOM   4269 O  OD1 . ASN A 1 717 ? 136.227 180.725 151.123 1.00 73.31  ? 707  ASN A OD1 1 
ATOM   4270 N  ND2 . ASN A 1 717 ? 135.142 182.688 151.231 1.00 73.31  ? 707  ASN A ND2 1 
ATOM   4271 N  N   . SER A 1 718 ? 137.722 179.891 148.732 1.00 70.24  ? 708  SER A N   1 
ATOM   4272 C  CA  . SER A 1 718 ? 138.732 178.940 149.188 1.00 70.24  ? 708  SER A CA  1 
ATOM   4273 C  C   . SER A 1 718 ? 139.975 178.965 148.307 1.00 70.24  ? 708  SER A C   1 
ATOM   4274 O  O   . SER A 1 718 ? 141.091 178.773 148.805 1.00 70.24  ? 708  SER A O   1 
ATOM   4275 C  CB  . SER A 1 718 ? 138.140 177.531 149.233 1.00 70.24  ? 708  SER A CB  1 
ATOM   4276 O  OG  . SER A 1 718 ? 138.975 176.651 149.964 1.00 70.24  ? 708  SER A OG  1 
ATOM   4277 N  N   . TRP A 1 719 ? 139.797 179.190 147.002 1.00 62.06  ? 709  TRP A N   1 
ATOM   4278 C  CA  . TRP A 1 719 ? 140.933 179.370 146.103 1.00 62.06  ? 709  TRP A CA  1 
ATOM   4279 C  C   . TRP A 1 719 ? 141.801 180.534 146.559 1.00 62.06  ? 709  TRP A C   1 
ATOM   4280 O  O   . TRP A 1 719 ? 143.031 180.417 146.652 1.00 62.06  ? 709  TRP A O   1 
ATOM   4281 C  CB  . TRP A 1 719 ? 140.428 179.626 144.683 1.00 62.06  ? 709  TRP A CB  1 
ATOM   4282 C  CG  . TRP A 1 719 ? 140.219 178.409 143.846 1.00 62.06  ? 709  TRP A CG  1 
ATOM   4283 C  CD1 . TRP A 1 719 ? 139.023 177.869 143.473 1.00 62.06  ? 709  TRP A CD1 1 
ATOM   4284 C  CD2 . TRP A 1 719 ? 141.229 177.603 143.239 1.00 62.06  ? 709  TRP A CD2 1 
ATOM   4285 N  NE1 . TRP A 1 719 ? 139.227 176.763 142.687 1.00 62.06  ? 709  TRP A NE1 1 
ATOM   4286 C  CE2 . TRP A 1 719 ? 140.575 176.580 142.527 1.00 62.06  ? 709  TRP A CE2 1 
ATOM   4287 C  CE3 . TRP A 1 719 ? 142.624 177.641 143.234 1.00 62.06  ? 709  TRP A CE3 1 
ATOM   4288 C  CZ2 . TRP A 1 719 ? 141.266 175.609 141.818 1.00 62.06  ? 709  TRP A CZ2 1 
ATOM   4289 C  CZ3 . TRP A 1 719 ? 143.308 176.675 142.533 1.00 62.06  ? 709  TRP A CZ3 1 
ATOM   4290 C  CH2 . TRP A 1 719 ? 142.629 175.671 141.836 1.00 62.06  ? 709  TRP A CH2 1 
ATOM   4291 N  N   . ARG A 1 720 ? 141.161 181.668 146.860 1.00 70.78  ? 710  ARG A N   1 
ATOM   4292 C  CA  . ARG A 1 720 ? 141.890 182.850 147.302 1.00 70.78  ? 710  ARG A CA  1 
ATOM   4293 C  C   . ARG A 1 720 ? 142.610 182.591 148.616 1.00 70.78  ? 710  ARG A C   1 
ATOM   4294 O  O   . ARG A 1 720 ? 143.770 182.984 148.776 1.00 70.78  ? 710  ARG A O   1 
ATOM   4295 C  CB  . ARG A 1 720 ? 140.933 184.035 147.441 1.00 70.78  ? 710  ARG A CB  1 
ATOM   4296 C  CG  . ARG A 1 720 ? 141.518 185.229 148.187 1.00 70.78  ? 710  ARG A CG  1 
ATOM   4297 C  CD  . ARG A 1 720 ? 140.438 186.016 148.913 1.00 70.78  ? 710  ARG A CD  1 
ATOM   4298 N  NE  . ARG A 1 720 ? 139.644 186.834 148.005 1.00 70.78  ? 710  ARG A NE  1 
ATOM   4299 C  CZ  . ARG A 1 720 ? 139.745 188.152 147.901 1.00 70.78  ? 710  ARG A CZ  1 
ATOM   4300 N  NH1 . ARG A 1 720 ? 140.606 188.840 148.633 1.00 70.78  ? 710  ARG A NH1 1 
ATOM   4301 N  NH2 . ARG A 1 720 ? 138.959 188.796 147.043 1.00 70.78  ? 710  ARG A NH2 1 
ATOM   4302 N  N   . GLU A 1 721 ? 141.939 181.919 149.560 1.00 72.53  ? 711  GLU A N   1 
ATOM   4303 C  CA  . GLU A 1 721 ? 142.549 181.626 150.855 1.00 72.53  ? 711  GLU A CA  1 
ATOM   4304 C  C   . GLU A 1 721 ? 143.762 180.720 150.704 1.00 72.53  ? 711  GLU A C   1 
ATOM   4305 O  O   . GLU A 1 721 ? 144.799 180.947 151.341 1.00 72.53  ? 711  GLU A O   1 
ATOM   4306 C  CB  . GLU A 1 721 ? 141.522 180.987 151.794 1.00 72.53  ? 711  GLU A CB  1 
ATOM   4307 C  CG  . GLU A 1 721 ? 140.272 181.821 152.045 1.00 72.53  ? 711  GLU A CG  1 
ATOM   4308 C  CD  . GLU A 1 721 ? 140.572 183.202 152.603 1.00 72.53  ? 711  GLU A CD  1 
ATOM   4309 O  OE1 . GLU A 1 721 ? 141.521 183.334 153.405 1.00 72.53  ? 711  GLU A OE1 1 
ATOM   4310 O  OE2 . GLU A 1 721 ? 139.856 184.158 152.237 1.00 72.53  ? 711  GLU A OE2 1 
ATOM   4311 N  N   . GLN A 1 722 ? 143.653 179.693 149.856 1.00 61.12  ? 712  GLN A N   1 
ATOM   4312 C  CA  . GLN A 1 722 ? 144.787 178.809 149.606 1.00 61.12  ? 712  GLN A CA  1 
ATOM   4313 C  C   . GLN A 1 722 ? 145.942 179.568 148.968 1.00 61.12  ? 712  GLN A C   1 
ATOM   4314 O  O   . GLN A 1 722 ? 147.109 179.350 149.318 1.00 61.12  ? 712  GLN A O   1 
ATOM   4315 C  CB  . GLN A 1 722 ? 144.349 177.642 148.720 1.00 61.12  ? 712  GLN A CB  1 
ATOM   4316 C  CG  . GLN A 1 722 ? 145.243 176.422 148.796 1.00 61.12  ? 712  GLN A CG  1 
ATOM   4317 C  CD  . GLN A 1 722 ? 144.504 175.144 148.449 1.00 61.12  ? 712  GLN A CD  1 
ATOM   4318 O  OE1 . GLN A 1 722 ? 143.516 175.165 147.717 1.00 61.12  ? 712  GLN A OE1 1 
ATOM   4319 N  NE2 . GLN A 1 722 ? 144.982 174.023 148.974 1.00 61.12  ? 712  GLN A NE2 1 
ATOM   4320 N  N   . PHE A 1 723 ? 145.633 180.479 148.042 1.00 59.58  ? 713  PHE A N   1 
ATOM   4321 C  CA  . PHE A 1 723 ? 146.687 181.252 147.394 1.00 59.58  ? 713  PHE A CA  1 
ATOM   4322 C  C   . PHE A 1 723 ? 147.397 182.188 148.370 1.00 59.58  ? 713  PHE A C   1 
ATOM   4323 O  O   . PHE A 1 723 ? 148.626 182.313 148.320 1.00 59.58  ? 713  PHE A O   1 
ATOM   4324 C  CB  . PHE A 1 723 ? 146.120 182.026 146.205 1.00 59.58  ? 713  PHE A CB  1 
ATOM   4325 C  CG  . PHE A 1 723 ? 146.259 181.301 144.896 1.00 59.58  ? 713  PHE A CG  1 
ATOM   4326 C  CD1 . PHE A 1 723 ? 145.393 180.276 144.556 1.00 59.58  ? 713  PHE A CD1 1 
ATOM   4327 C  CD2 . PHE A 1 723 ? 147.268 181.637 144.011 1.00 59.58  ? 713  PHE A CD2 1 
ATOM   4328 C  CE1 . PHE A 1 723 ? 145.525 179.608 143.357 1.00 59.58  ? 713  PHE A CE1 1 
ATOM   4329 C  CE2 . PHE A 1 723 ? 147.404 180.972 142.809 1.00 59.58  ? 713  PHE A CE2 1 
ATOM   4330 C  CZ  . PHE A 1 723 ? 146.532 179.956 142.483 1.00 59.58  ? 713  PHE A CZ  1 
ATOM   4331 N  N   . ILE A 1 724 ? 146.658 182.863 149.260 1.00 68.37  ? 714  ILE A N   1 
ATOM   4332 C  CA  . ILE A 1 724 ? 147.356 183.777 150.170 1.00 68.37  ? 714  ILE A CA  1 
ATOM   4333 C  C   . ILE A 1 724 ? 148.085 182.995 151.250 1.00 68.37  ? 714  ILE A C   1 
ATOM   4334 O  O   . ILE A 1 724 ? 149.120 183.444 151.755 1.00 68.37  ? 714  ILE A O   1 
ATOM   4335 C  CB  . ILE A 1 724 ? 146.433 184.829 150.818 1.00 68.37  ? 714  ILE A CB  1 
ATOM   4336 C  CG1 . ILE A 1 724 ? 145.081 184.239 151.204 1.00 68.37  ? 714  ILE A CG1 1 
ATOM   4337 C  CG2 . ILE A 1 724 ? 146.267 186.025 149.892 1.00 68.37  ? 714  ILE A CG2 1 
ATOM   4338 C  CD1 . ILE A 1 724 ? 144.094 185.248 151.752 1.00 68.37  ? 714  ILE A CD1 1 
ATOM   4339 N  N   . GLU A 1 725 ? 147.569 181.823 151.634 1.00 73.39  ? 715  GLU A N   1 
ATOM   4340 C  CA  . GLU A 1 725 ? 148.283 181.010 152.610 1.00 73.39  ? 715  GLU A CA  1 
ATOM   4341 C  C   . GLU A 1 725 ? 149.542 180.403 152.006 1.00 73.39  ? 715  GLU A C   1 
ATOM   4342 O  O   . GLU A 1 725 ? 150.502 180.118 152.732 1.00 73.39  ? 715  GLU A O   1 
ATOM   4343 C  CB  . GLU A 1 725 ? 147.363 179.918 153.158 1.00 73.39  ? 715  GLU A CB  1 
ATOM   4344 C  CG  . GLU A 1 725 ? 147.903 179.221 154.397 1.00 73.39  ? 715  GLU A CG  1 
ATOM   4345 C  CD  . GLU A 1 725 ? 147.296 177.851 154.615 1.00 73.39  ? 715  GLU A CD  1 
ATOM   4346 O  OE1 . GLU A 1 725 ? 146.943 177.191 153.616 1.00 73.39  ? 715  GLU A OE1 1 
ATOM   4347 O  OE2 . GLU A 1 725 ? 147.179 177.431 155.785 1.00 73.39  ? 715  GLU A OE2 1 
ATOM   4348 N  N   . ALA A 1 726 ? 149.556 180.201 150.686 1.00 62.96  ? 716  ALA A N   1 
ATOM   4349 C  CA  . ALA A 1 726 ? 150.769 179.737 150.021 1.00 62.96  ? 716  ALA A CA  1 
ATOM   4350 C  C   . ALA A 1 726 ? 151.897 180.756 150.142 1.00 62.96  ? 716  ALA A C   1 
ATOM   4351 O  O   . ALA A 1 726 ? 153.047 180.388 150.407 1.00 62.96  ? 716  ALA A O   1 
ATOM   4352 C  CB  . ALA A 1 726 ? 150.479 179.432 148.552 1.00 62.96  ? 716  ALA A CB  1 
ATOM   4353 N  N   . ILE A 1 727 ? 151.591 182.036 149.958 1.00 68.30  ? 717  ILE A N   1 
ATOM   4354 C  CA  . ILE A 1 727 ? 152.594 183.102 150.019 1.00 68.30  ? 717  ILE A CA  1 
ATOM   4355 C  C   . ILE A 1 727 ? 152.483 183.793 151.381 1.00 68.30  ? 717  ILE A C   1 
ATOM   4356 O  O   . ILE A 1 727 ? 151.684 184.703 151.609 1.00 68.30  ? 717  ILE A O   1 
ATOM   4357 C  CB  . ILE A 1 727 ? 152.492 184.052 148.816 1.00 68.30  ? 717  ILE A CB  1 
ATOM   4358 C  CG1 . ILE A 1 727 ? 151.131 184.755 148.702 1.00 68.30  ? 717  ILE A CG1 1 
ATOM   4359 C  CG2 . ILE A 1 727 ? 152.808 183.312 147.527 1.00 68.30  ? 717  ILE A CG2 1 
ATOM   4360 C  CD1 . ILE A 1 727 ? 151.086 185.844 147.658 1.00 68.30  ? 717  ILE A CD1 1 
ATOM   4361 N  N   . THR A 1 728 ? 153.301 183.335 152.324 1.00 71.51  ? 718  THR A N   1 
ATOM   4362 C  CA  . THR A 1 728 ? 153.357 183.948 153.648 1.00 71.51  ? 718  THR A CA  1 
ATOM   4363 C  C   . THR A 1 728 ? 154.800 184.112 154.109 1.00 71.51  ? 718  THR A C   1 
ATOM   4364 O  O   . THR A 1 728 ? 155.278 183.359 154.957 1.00 71.51  ? 718  THR A O   1 
ATOM   4365 C  CB  . THR A 1 728 ? 152.589 183.123 154.701 1.00 71.51  ? 718  THR A CB  1 
ATOM   4366 O  OG1 . THR A 1 728 ? 153.003 181.754 154.637 1.00 71.51  ? 718  THR A OG1 1 
ATOM   4367 C  CG2 . THR A 1 728 ? 151.085 183.218 154.484 1.00 71.51  ? 718  THR A CG2 1 
ATOM   4368 N  N   . SER A 1 747 ? 162.923 182.028 164.311 1.00 97.84  ? 737  SER A N   1 
ATOM   4369 C  CA  . SER A 1 747 ? 161.887 182.330 163.330 1.00 97.84  ? 737  SER A CA  1 
ATOM   4370 C  C   . SER A 1 747 ? 162.471 182.435 161.926 1.00 97.84  ? 737  SER A C   1 
ATOM   4371 O  O   . SER A 1 747 ? 161.762 182.250 160.938 1.00 97.84  ? 737  SER A O   1 
ATOM   4372 C  CB  . SER A 1 747 ? 161.164 183.628 163.696 1.00 97.84  ? 737  SER A CB  1 
ATOM   4373 O  OG  . SER A 1 747 ? 160.081 183.876 162.817 1.00 97.84  ? 737  SER A OG  1 
ATOM   4374 N  N   . CYS A 1 748 ? 163.771 182.736 161.849 1.00 97.92  ? 738  CYS A N   1 
ATOM   4375 C  CA  . CYS A 1 748 ? 164.428 182.883 160.553 1.00 97.92  ? 738  CYS A CA  1 
ATOM   4376 C  C   . CYS A 1 748 ? 164.493 181.563 159.796 1.00 97.92  ? 738  CYS A C   1 
ATOM   4377 O  O   . CYS A 1 748 ? 164.458 181.559 158.560 1.00 97.92  ? 738  CYS A O   1 
ATOM   4378 C  CB  . CYS A 1 748 ? 165.833 183.456 160.739 1.00 97.92  ? 738  CYS A CB  1 
ATOM   4379 S  SG  . CYS A 1 748 ? 166.673 183.880 159.195 1.00 97.92  ? 738  CYS A SG  1 
ATOM   4380 N  N   . PHE A 1 749 ? 164.596 180.442 160.515 1.00 99.97  ? 739  PHE A N   1 
ATOM   4381 C  CA  . PHE A 1 749 ? 164.604 179.132 159.868 1.00 99.97  ? 739  PHE A CA  1 
ATOM   4382 C  C   . PHE A 1 749 ? 163.294 178.873 159.135 1.00 99.97  ? 739  PHE A C   1 
ATOM   4383 O  O   . PHE A 1 749 ? 163.287 178.286 158.045 1.00 99.97  ? 739  PHE A O   1 
ATOM   4384 C  CB  . PHE A 1 749 ? 164.868 178.042 160.907 1.00 99.97  ? 739  PHE A CB  1 
ATOM   4385 C  CG  . PHE A 1 749 ? 164.461 176.667 160.462 1.00 99.97  ? 739  PHE A CG  1 
ATOM   4386 C  CD1 . PHE A 1 749 ? 165.152 176.016 159.453 1.00 99.97  ? 739  PHE A CD1 1 
ATOM   4387 C  CD2 . PHE A 1 749 ? 163.386 176.025 161.055 1.00 99.97  ? 739  PHE A CD2 1 
ATOM   4388 C  CE1 . PHE A 1 749 ? 164.778 174.751 159.044 1.00 99.97  ? 739  PHE A CE1 1 
ATOM   4389 C  CE2 . PHE A 1 749 ? 163.007 174.760 160.650 1.00 99.97  ? 739  PHE A CE2 1 
ATOM   4390 C  CZ  . PHE A 1 749 ? 163.704 174.123 159.643 1.00 99.97  ? 739  PHE A CZ  1 
ATOM   4391 N  N   . ASP A 1 750 ? 162.174 179.304 159.722 1.00 98.68  ? 740  ASP A N   1 
ATOM   4392 C  CA  . ASP A 1 750 ? 160.888 179.197 159.043 1.00 98.68  ? 740  ASP A CA  1 
ATOM   4393 C  C   . ASP A 1 750 ? 160.871 180.027 157.766 1.00 98.68  ? 740  ASP A C   1 
ATOM   4394 O  O   . ASP A 1 750 ? 160.329 179.593 156.745 1.00 98.68  ? 740  ASP A O   1 
ATOM   4395 C  CB  . ASP A 1 750 ? 159.763 179.632 159.981 1.00 98.68  ? 740  ASP A CB  1 
ATOM   4396 C  CG  . ASP A 1 750 ? 159.980 179.164 161.406 1.00 98.68  ? 740  ASP A CG  1 
ATOM   4397 O  OD1 . ASP A 1 750 ? 160.591 178.091 161.592 1.00 98.68  ? 740  ASP A OD1 1 
ATOM   4398 O  OD2 . ASP A 1 750 ? 159.543 179.870 162.338 1.00 98.68  ? 740  ASP A OD2 1 
ATOM   4399 N  N   . TYR A 1 751 ? 161.463 181.226 157.808 1.00 95.85  ? 741  TYR A N   1 
ATOM   4400 C  CA  . TYR A 1 751 ? 161.563 182.056 156.610 1.00 95.85  ? 741  TYR A CA  1 
ATOM   4401 C  C   . TYR A 1 751 ? 162.389 181.372 155.528 1.00 95.85  ? 741  TYR A C   1 
ATOM   4402 O  O   . TYR A 1 751 ? 162.012 181.383 154.348 1.00 95.85  ? 741  TYR A O   1 
ATOM   4403 C  CB  . TYR A 1 751 ? 162.178 183.415 156.955 1.00 95.85  ? 741  TYR A CB  1 
ATOM   4404 C  CG  . TYR A 1 751 ? 161.240 184.418 157.596 1.00 95.85  ? 741  TYR A CG  1 
ATOM   4405 C  CD1 . TYR A 1 751 ? 160.493 184.092 158.721 1.00 95.85  ? 741  TYR A CD1 1 
ATOM   4406 C  CD2 . TYR A 1 751 ? 161.118 185.702 157.081 1.00 95.85  ? 741  TYR A CD2 1 
ATOM   4407 C  CE1 . TYR A 1 751 ? 159.644 185.011 159.308 1.00 95.85  ? 741  TYR A CE1 1 
ATOM   4408 C  CE2 . TYR A 1 751 ? 160.272 186.628 157.660 1.00 95.85  ? 741  TYR A CE2 1 
ATOM   4409 C  CZ  . TYR A 1 751 ? 159.537 186.278 158.773 1.00 95.85  ? 741  TYR A CZ  1 
ATOM   4410 O  OH  . TYR A 1 751 ? 158.693 187.198 159.353 1.00 95.85  ? 741  TYR A OH  1 
ATOM   4411 N  N   . VAL A 1 752 ? 163.520 180.773 155.913 1.00 89.75  ? 742  VAL A N   1 
ATOM   4412 C  CA  . VAL A 1 752 ? 164.373 180.088 154.944 1.00 89.75  ? 742  VAL A CA  1 
ATOM   4413 C  C   . VAL A 1 752 ? 163.635 178.911 154.321 1.00 89.75  ? 742  VAL A C   1 
ATOM   4414 O  O   . VAL A 1 752 ? 163.665 178.718 153.099 1.00 89.75  ? 742  VAL A O   1 
ATOM   4415 C  CB  . VAL A 1 752 ? 165.691 179.644 155.608 1.00 89.75  ? 742  VAL A CB  1 
ATOM   4416 C  CG1 . VAL A 1 752 ? 166.548 178.863 154.624 1.00 89.75  ? 742  VAL A CG1 1 
ATOM   4417 C  CG2 . VAL A 1 752 ? 166.453 180.851 156.122 1.00 89.75  ? 742  VAL A CG2 1 
ATOM   4418 N  N   . MET A 1 753 ? 162.944 178.120 155.147 1.00 86.62  ? 743  MET A N   1 
ATOM   4419 C  CA  . MET A 1 753 ? 162.197 176.976 154.630 1.00 86.62  ? 743  MET A CA  1 
ATOM   4420 C  C   . MET A 1 753 ? 161.069 177.421 153.706 1.00 86.62  ? 743  MET A C   1 
ATOM   4421 O  O   . MET A 1 753 ? 160.856 176.824 152.643 1.00 86.62  ? 743  MET A O   1 
ATOM   4422 C  CB  . MET A 1 753 ? 161.645 176.147 155.789 1.00 86.62  ? 743  MET A CB  1 
ATOM   4423 C  CG  . MET A 1 753 ? 161.284 174.718 155.419 1.00 86.62  ? 743  MET A CG  1 
ATOM   4424 S  SD  . MET A 1 753 ? 162.722 173.631 155.336 1.00 86.62  ? 743  MET A SD  1 
ATOM   4425 C  CE  . MET A 1 753 ? 161.934 172.023 155.323 1.00 86.62  ? 743  MET A CE  1 
ATOM   4426 N  N   . HIS A 1 754 ? 160.346 178.478 154.086 1.00 80.22  ? 744  HIS A N   1 
ATOM   4427 C  CA  . HIS A 1 754 ? 159.244 178.958 153.260 1.00 80.22  ? 744  HIS A CA  1 
ATOM   4428 C  C   . HIS A 1 754 ? 159.743 179.478 151.918 1.00 80.22  ? 744  HIS A C   1 
ATOM   4429 O  O   . HIS A 1 754 ? 159.136 179.211 150.877 1.00 80.22  ? 744  HIS A O   1 
ATOM   4430 C  CB  . HIS A 1 754 ? 158.461 180.042 153.998 1.00 80.22  ? 744  HIS A CB  1 
ATOM   4431 C  CG  . HIS A 1 754 ? 157.702 180.955 153.088 1.00 80.22  ? 744  HIS A CG  1 
ATOM   4432 N  ND1 . HIS A 1 754 ? 156.720 180.504 152.232 1.00 80.22  ? 744  HIS A ND1 1 
ATOM   4433 C  CD2 . HIS A 1 754 ? 157.784 182.292 152.895 1.00 80.22  ? 744  HIS A CD2 1 
ATOM   4434 C  CE1 . HIS A 1 754 ? 156.231 181.524 151.550 1.00 80.22  ? 744  HIS A CE1 1 
ATOM   4435 N  NE2 . HIS A 1 754 ? 156.858 182.621 151.935 1.00 80.22  ? 744  HIS A NE2 1 
ATOM   4436 N  N   . PHE A 1 755 ? 160.847 180.231 151.919 1.00 80.79  ? 745  PHE A N   1 
ATOM   4437 C  CA  . PHE A 1 755 ? 161.383 180.726 150.655 1.00 80.79  ? 745  PHE A CA  1 
ATOM   4438 C  C   . PHE A 1 755 ? 161.900 179.563 149.807 1.00 80.79  ? 745  PHE A C   1 
ATOM   4439 O  O   . PHE A 1 755 ? 161.741 179.556 148.581 1.00 80.79  ? 745  PHE A O   1 
ATOM   4440 C  CB  . PHE A 1 755 ? 162.483 181.758 150.932 1.00 80.79  ? 745  PHE A CB  1 
ATOM   4441 C  CG  . PHE A 1 755 ? 162.881 182.600 149.733 1.00 80.79  ? 745  PHE A CG  1 
ATOM   4442 C  CD1 . PHE A 1 755 ? 162.140 182.585 148.560 1.00 80.79  ? 745  PHE A CD1 1 
ATOM   4443 C  CD2 . PHE A 1 755 ? 164.002 183.416 149.793 1.00 80.79  ? 745  PHE A CD2 1 
ATOM   4444 C  CE1 . PHE A 1 755 ? 162.508 183.360 147.474 1.00 80.79  ? 745  PHE A CE1 1 
ATOM   4445 C  CE2 . PHE A 1 755 ? 164.375 184.193 148.708 1.00 80.79  ? 745  PHE A CE2 1 
ATOM   4446 C  CZ  . PHE A 1 755 ? 163.626 184.163 147.548 1.00 80.79  ? 745  PHE A CZ  1 
ATOM   4447 N  N   . LEU A 1 756 ? 162.472 178.567 150.483 1.00 70.37  ? 746  LEU A N   1 
ATOM   4448 C  CA  . LEU A 1 756 ? 163.042 177.375 149.848 1.00 70.37  ? 746  LEU A CA  1 
ATOM   4449 C  C   . LEU A 1 756 ? 162.013 176.479 149.170 1.00 70.37  ? 746  LEU A C   1 
ATOM   4450 O  O   . LEU A 1 756 ? 162.325 175.766 148.223 1.00 70.37  ? 746  LEU A O   1 
ATOM   4451 C  CB  . LEU A 1 756 ? 163.817 176.558 150.875 1.00 70.37  ? 746  LEU A CB  1 
ATOM   4452 C  CG  . LEU A 1 756 ? 164.294 175.238 150.292 1.00 70.37  ? 746  LEU A CG  1 
ATOM   4453 C  CD1 . LEU A 1 756 ? 164.918 175.542 148.947 1.00 70.37  ? 746  LEU A CD1 1 
ATOM   4454 C  CD2 . LEU A 1 756 ? 165.285 174.544 151.212 1.00 70.37  ? 746  LEU A CD2 1 
ATOM   4455 N  N   . THR A 1 757 ? 160.797 176.486 149.692 1.00 62.74  ? 747  THR A N   1 
ATOM   4456 C  CA  . THR A 1 757 ? 159.704 175.712 149.104 1.00 62.74  ? 747  THR A CA  1 
ATOM   4457 C  C   . THR A 1 757 ? 158.596 176.567 148.490 1.00 62.74  ? 747  THR A C   1 
ATOM   4458 O  O   . THR A 1 757 ? 157.539 176.021 148.146 1.00 62.74  ? 747  THR A O   1 
ATOM   4459 C  CB  . THR A 1 757 ? 159.087 174.751 150.128 1.00 62.74  ? 747  THR A CB  1 
ATOM   4460 O  OG1 . THR A 1 757 ? 158.038 175.409 150.851 1.00 62.74  ? 747  THR A OG1 1 
ATOM   4461 C  CG2 . THR A 1 757 ? 160.129 174.193 151.083 1.00 62.74  ? 747  THR A CG2 1 
ATOM   4462 N  N   . VAL A 1 758 ? 158.795 177.885 148.360 1.00 58.96  ? 748  VAL A N   1 
ATOM   4463 C  CA  . VAL A 1 758 ? 157.747 178.757 147.829 1.00 58.96  ? 748  VAL A CA  1 
ATOM   4464 C  C   . VAL A 1 758 ? 157.376 178.435 146.387 1.00 58.96  ? 748  VAL A C   1 
ATOM   4465 O  O   . VAL A 1 758 ? 156.219 178.628 146.003 1.00 58.96  ? 748  VAL A O   1 
ATOM   4466 C  CB  . VAL A 1 758 ? 158.158 180.245 147.987 1.00 58.96  ? 748  VAL A CB  1 
ATOM   4467 C  CG1 . VAL A 1 758 ? 159.169 180.676 146.927 1.00 58.96  ? 748  VAL A CG1 1 
ATOM   4468 C  CG2 . VAL A 1 758 ? 156.932 181.146 147.963 1.00 58.96  ? 748  VAL A CG2 1 
ATOM   4469 N  N   . PHE A 1 759 ? 158.305 177.895 145.592 1.00 48.95  ? 749  PHE A N   1 
ATOM   4470 C  CA  . PHE A 1 759 ? 157.967 177.529 144.220 1.00 48.95  ? 749  PHE A CA  1 
ATOM   4471 C  C   . PHE A 1 759 ? 156.957 176.389 144.216 1.00 48.95  ? 749  PHE A C   1 
ATOM   4472 O  O   . PHE A 1 759 ? 155.933 176.455 143.526 1.00 48.95  ? 749  PHE A O   1 
ATOM   4473 C  CB  . PHE A 1 759 ? 159.236 177.137 143.453 1.00 48.95  ? 749  PHE A CB  1 
ATOM   4474 C  CG  . PHE A 1 759 ? 159.013 176.790 141.993 1.00 48.95  ? 749  PHE A CG  1 
ATOM   4475 C  CD1 . PHE A 1 759 ? 157.920 177.277 141.287 1.00 48.95  ? 749  PHE A CD1 1 
ATOM   4476 C  CD2 . PHE A 1 759 ? 159.905 175.963 141.332 1.00 48.95  ? 749  PHE A CD2 1 
ATOM   4477 C  CE1 . PHE A 1 759 ? 157.729 176.947 139.958 1.00 48.95  ? 749  PHE A CE1 1 
ATOM   4478 C  CE2 . PHE A 1 759 ? 159.718 175.630 140.002 1.00 48.95  ? 749  PHE A CE2 1 
ATOM   4479 C  CZ  . PHE A 1 759 ? 158.630 176.123 139.316 1.00 48.95  ? 749  PHE A CZ  1 
ATOM   4480 N  N   . TRP A 1 760 ? 157.217 175.354 145.012 1.00 40.21  ? 750  TRP A N   1 
ATOM   4481 C  CA  . TRP A 1 760 ? 156.313 174.214 145.047 1.00 40.21  ? 750  TRP A CA  1 
ATOM   4482 C  C   . TRP A 1 760 ? 154.985 174.584 145.694 1.00 40.21  ? 750  TRP A C   1 
ATOM   4483 O  O   . TRP A 1 760 ? 153.930 174.127 145.244 1.00 40.21  ? 750  TRP A O   1 
ATOM   4484 C  CB  . TRP A 1 760 ? 156.980 173.047 145.770 1.00 40.21  ? 750  TRP A CB  1 
ATOM   4485 C  CG  . TRP A 1 760 ? 158.138 172.485 145.004 1.00 40.21  ? 750  TRP A CG  1 
ATOM   4486 C  CD1 . TRP A 1 760 ? 159.431 172.417 145.422 1.00 40.21  ? 750  TRP A CD1 1 
ATOM   4487 C  CD2 . TRP A 1 760 ? 158.113 171.915 143.687 1.00 40.21  ? 750  TRP A CD2 1 
ATOM   4488 N  NE1 . TRP A 1 760 ? 160.214 171.845 144.452 1.00 40.21  ? 750  TRP A NE1 1 
ATOM   4489 C  CE2 . TRP A 1 760 ? 159.429 171.527 143.378 1.00 40.21  ? 750  TRP A CE2 1 
ATOM   4490 C  CE3 . TRP A 1 760 ? 157.107 171.695 142.742 1.00 40.21  ? 750  TRP A CE3 1 
ATOM   4491 C  CZ2 . TRP A 1 760 ? 159.765 170.933 142.166 1.00 40.21  ? 750  TRP A CZ2 1 
ATOM   4492 C  CZ3 . TRP A 1 760 ? 157.444 171.105 141.539 1.00 40.21  ? 750  TRP A CZ3 1 
ATOM   4493 C  CH2 . TRP A 1 760 ? 158.760 170.730 141.262 1.00 40.21  ? 750  TRP A CH2 1 
ATOM   4494 N  N   . LYS A 1 761 ? 155.010 175.420 146.737 1.00 50.72  ? 751  LYS A N   1 
ATOM   4495 C  CA  . LYS A 1 761 ? 153.755 175.841 147.358 1.00 50.72  ? 751  LYS A CA  1 
ATOM   4496 C  C   . LYS A 1 761 ? 152.908 176.675 146.401 1.00 50.72  ? 751  LYS A C   1 
ATOM   4497 O  O   . LYS A 1 761 ? 151.691 176.482 146.316 1.00 50.72  ? 751  LYS A O   1 
ATOM   4498 C  CB  . LYS A 1 761 ? 154.026 176.599 148.658 1.00 50.72  ? 751  LYS A CB  1 
ATOM   4499 C  CG  . LYS A 1 761 ? 154.789 175.780 149.690 1.00 50.72  ? 751  LYS A CG  1 
ATOM   4500 C  CD  . LYS A 1 761 ? 154.443 176.172 151.120 1.00 50.72  ? 751  LYS A CD  1 
ATOM   4501 C  CE  . LYS A 1 761 ? 154.639 177.661 151.353 1.00 50.72  ? 751  LYS A CE  1 
ATOM   4502 N  NZ  . LYS A 1 761 ? 154.228 178.081 152.722 1.00 50.72  ? 751  LYS A NZ  1 
ATOM   4503 N  N   . VAL A 1 762 ? 153.534 177.583 145.646 1.00 49.56  ? 752  VAL A N   1 
ATOM   4504 C  CA  . VAL A 1 762 ? 152.791 178.376 144.670 1.00 49.56  ? 752  VAL A CA  1 
ATOM   4505 C  C   . VAL A 1 762 ? 152.236 177.483 143.566 1.00 49.56  ? 752  VAL A C   1 
ATOM   4506 O  O   . VAL A 1 762 ? 151.072 177.618 143.171 1.00 49.56  ? 752  VAL A O   1 
ATOM   4507 C  CB  . VAL A 1 762 ? 153.687 179.499 144.110 1.00 49.56  ? 752  VAL A CB  1 
ATOM   4508 C  CG1 . VAL A 1 762 ? 153.265 179.898 142.699 1.00 49.56  ? 752  VAL A CG1 1 
ATOM   4509 C  CG2 . VAL A 1 762 ? 153.664 180.700 145.032 1.00 49.56  ? 752  VAL A CG2 1 
ATOM   4510 N  N   . LEU A 1 763 ? 153.049 176.548 143.064 1.00 44.55  ? 753  LEU A N   1 
ATOM   4511 C  CA  . LEU A 1 763 ? 152.599 175.680 141.980 1.00 44.55  ? 753  LEU A CA  1 
ATOM   4512 C  C   . LEU A 1 763 ? 151.463 174.767 142.426 1.00 44.55  ? 753  LEU A C   1 
ATOM   4513 O  O   . LEU A 1 763 ? 150.499 174.556 141.680 1.00 44.55  ? 753  LEU A O   1 
ATOM   4514 C  CB  . LEU A 1 763 ? 153.773 174.862 141.443 1.00 44.55  ? 753  LEU A CB  1 
ATOM   4515 C  CG  . LEU A 1 763 ? 153.483 173.892 140.298 1.00 44.55  ? 753  LEU A CG  1 
ATOM   4516 C  CD1 . LEU A 1 763 ? 152.890 174.627 139.109 1.00 44.55  ? 753  LEU A CD1 1 
ATOM   4517 C  CD2 . LEU A 1 763 ? 154.755 173.163 139.899 1.00 44.55  ? 753  LEU A CD2 1 
ATOM   4518 N  N   . PHE A 1 764 ? 151.549 174.223 143.642 1.00 39.45  ? 754  PHE A N   1 
ATOM   4519 C  CA  . PHE A 1 764 ? 150.523 173.317 144.141 1.00 39.45  ? 754  PHE A CA  1 
ATOM   4520 C  C   . PHE A 1 764 ? 149.339 174.045 144.759 1.00 39.45  ? 754  PHE A C   1 
ATOM   4521 O  O   . PHE A 1 764 ? 148.355 173.392 145.120 1.00 39.45  ? 754  PHE A O   1 
ATOM   4522 C  CB  . PHE A 1 764 ? 151.127 172.348 145.159 1.00 39.45  ? 754  PHE A CB  1 
ATOM   4523 C  CG  . PHE A 1 764 ? 152.212 171.482 144.592 1.00 39.45  ? 754  PHE A CG  1 
ATOM   4524 C  CD1 . PHE A 1 764 ? 152.156 171.052 143.280 1.00 39.45  ? 754  PHE A CD1 1 
ATOM   4525 C  CD2 . PHE A 1 764 ? 153.284 171.095 145.370 1.00 39.45  ? 754  PHE A CD2 1 
ATOM   4526 C  CE1 . PHE A 1 764 ? 153.154 170.261 142.755 1.00 39.45  ? 754  PHE A CE1 1 
ATOM   4527 C  CE2 . PHE A 1 764 ? 154.282 170.302 144.849 1.00 39.45  ? 754  PHE A CE2 1 
ATOM   4528 C  CZ  . PHE A 1 764 ? 154.215 169.883 143.541 1.00 39.45  ? 754  PHE A CZ  1 
ATOM   4529 N  N   . ALA A 1 765 ? 149.410 175.370 144.906 1.00 46.81  ? 755  ALA A N   1 
ATOM   4530 C  CA  . ALA A 1 765 ? 148.208 176.132 145.214 1.00 46.81  ? 755  ALA A CA  1 
ATOM   4531 C  C   . ALA A 1 765 ? 147.217 176.119 144.058 1.00 46.81  ? 755  ALA A C   1 
ATOM   4532 O  O   . ALA A 1 765 ? 146.033 176.398 144.269 1.00 46.81  ? 755  ALA A O   1 
ATOM   4533 C  CB  . ALA A 1 765 ? 148.573 177.570 145.580 1.00 46.81  ? 755  ALA A CB  1 
ATOM   4534 N  N   . PHE A 1 766 ? 147.675 175.799 142.846 1.00 50.68  ? 756  PHE A N   1 
ATOM   4535 C  CA  . PHE A 1 766 ? 146.786 175.633 141.703 1.00 50.68  ? 756  PHE A CA  1 
ATOM   4536 C  C   . PHE A 1 766 ? 145.995 174.333 141.759 1.00 50.68  ? 756  PHE A C   1 
ATOM   4537 O  O   . PHE A 1 766 ? 145.139 174.113 140.897 1.00 50.68  ? 756  PHE A O   1 
ATOM   4538 C  CB  . PHE A 1 766 ? 147.586 175.696 140.400 1.00 50.68  ? 756  PHE A CB  1 
ATOM   4539 C  CG  . PHE A 1 766 ? 148.047 177.080 140.037 1.00 50.68  ? 756  PHE A CG  1 
ATOM   4540 C  CD1 . PHE A 1 766 ? 149.188 177.618 140.608 1.00 50.68  ? 756  PHE A CD1 1 
ATOM   4541 C  CD2 . PHE A 1 766 ? 147.338 177.842 139.125 1.00 50.68  ? 756  PHE A CD2 1 
ATOM   4542 C  CE1 . PHE A 1 766 ? 149.614 178.890 140.276 1.00 50.68  ? 756  PHE A CE1 1 
ATOM   4543 C  CE2 . PHE A 1 766 ? 147.759 179.115 138.789 1.00 50.68  ? 756  PHE A CE2 1 
ATOM   4544 C  CZ  . PHE A 1 766 ? 148.898 179.639 139.366 1.00 50.68  ? 756  PHE A CZ  1 
ATOM   4545 N  N   . VAL A 1 767 ? 146.285 173.460 142.715 1.00 44.68  ? 757  VAL A N   1 
ATOM   4546 C  CA  . VAL A 1 767 ? 145.449 172.276 142.942 1.00 44.68  ? 757  VAL A CA  1 
ATOM   4547 C  C   . VAL A 1 767 ? 144.112 172.721 143.520 1.00 44.68  ? 757  VAL A C   1 
ATOM   4548 O  O   . VAL A 1 767 ? 144.091 173.592 144.408 1.00 44.68  ? 757  VAL A O   1 
ATOM   4549 C  CB  . VAL A 1 767 ? 146.165 171.300 143.880 1.00 44.68  ? 757  VAL A CB  1 
ATOM   4550 C  CG1 . VAL A 1 767 ? 145.291 170.105 144.205 1.00 44.68  ? 757  VAL A CG1 1 
ATOM   4551 C  CG2 . VAL A 1 767 ? 147.473 170.841 143.262 1.00 44.68  ? 757  VAL A CG2 1 
ATOM   4552 N  N   . PRO A 1 768 ? 142.985 172.201 143.039 1.00 44.76  ? 758  PRO A N   1 
ATOM   4553 C  CA  . PRO A 1 768 ? 141.682 172.594 143.591 1.00 44.76  ? 758  PRO A CA  1 
ATOM   4554 C  C   . PRO A 1 768 ? 141.554 172.203 145.051 1.00 44.76  ? 758  PRO A C   1 
ATOM   4555 O  O   . PRO A 1 768 ? 142.092 171.169 145.474 1.00 44.76  ? 758  PRO A O   1 
ATOM   4556 C  CB  . PRO A 1 768 ? 140.677 171.826 142.717 1.00 44.76  ? 758  PRO A CB  1 
ATOM   4557 C  CG  . PRO A 1 768 ? 141.471 170.749 142.067 1.00 44.76  ? 758  PRO A CG  1 
ATOM   4558 C  CD  . PRO A 1 768 ? 142.836 171.320 141.871 1.00 44.76  ? 758  PRO A CD  1 
ATOM   4559 N  N   . PRO A 1 769 ? 140.864 173.014 145.853 1.00 54.24  ? 759  PRO A N   1 
ATOM   4560 C  CA  . PRO A 1 769 ? 140.686 172.683 147.270 1.00 54.24  ? 759  PRO A CA  1 
ATOM   4561 C  C   . PRO A 1 769 ? 139.853 171.424 147.455 1.00 54.24  ? 759  PRO A C   1 
ATOM   4562 O  O   . PRO A 1 769 ? 139.060 171.031 146.597 1.00 54.24  ? 759  PRO A O   1 
ATOM   4563 C  CB  . PRO A 1 769 ? 139.968 173.912 147.839 1.00 54.24  ? 759  PRO A CB  1 
ATOM   4564 C  CG  . PRO A 1 769 ? 140.276 175.012 146.887 1.00 54.24  ? 759  PRO A CG  1 
ATOM   4565 C  CD  . PRO A 1 769 ? 140.396 174.373 145.538 1.00 54.24  ? 759  PRO A CD  1 
ATOM   4566 N  N   . THR A 1 770 ? 140.050 170.786 148.610 1.00 53.52  ? 760  THR A N   1 
ATOM   4567 C  CA  . THR A 1 770 ? 139.450 169.490 148.896 1.00 53.52  ? 760  THR A CA  1 
ATOM   4568 C  C   . THR A 1 770 ? 137.943 169.553 149.111 1.00 53.52  ? 760  THR A C   1 
ATOM   4569 O  O   . THR A 1 770 ? 137.311 168.497 149.214 1.00 53.52  ? 760  THR A O   1 
ATOM   4570 C  CB  . THR A 1 770 ? 140.113 168.873 150.127 1.00 53.52  ? 760  THR A CB  1 
ATOM   4571 O  OG1 . THR A 1 770 ? 139.625 169.522 151.307 1.00 53.52  ? 760  THR A OG1 1 
ATOM   4572 C  CG2 . THR A 1 770 ? 141.619 169.046 150.053 1.00 53.52  ? 760  THR A CG2 1 
ATOM   4573 N  N   . GLU A 1 771 ? 137.351 170.744 149.205 1.00 62.24  ? 761  GLU A N   1 
ATOM   4574 C  CA  . GLU A 1 771 ? 135.903 170.823 149.358 1.00 62.24  ? 761  GLU A CA  1 
ATOM   4575 C  C   . GLU A 1 771 ? 135.165 170.562 148.048 1.00 62.24  ? 761  GLU A C   1 
ATOM   4576 O  O   . GLU A 1 771 ? 134.047 170.035 148.072 1.00 62.24  ? 761  GLU A O   1 
ATOM   4577 C  CB  . GLU A 1 771 ? 135.507 172.184 149.936 1.00 62.24  ? 761  GLU A CB  1 
ATOM   4578 C  CG  . GLU A 1 771 ? 136.097 173.377 149.210 1.00 62.24  ? 761  GLU A CG  1 
ATOM   4579 C  CD  . GLU A 1 771 ? 135.459 174.688 149.625 1.00 62.24  ? 761  GLU A CD  1 
ATOM   4580 O  OE1 . GLU A 1 771 ? 135.937 175.302 150.602 1.00 62.24  ? 761  GLU A OE1 1 
ATOM   4581 O  OE2 . GLU A 1 771 ? 134.480 175.106 148.973 1.00 62.24  ? 761  GLU A OE2 1 
ATOM   4582 N  N   . TYR A 1 772 ? 135.761 170.916 146.911 1.00 58.39  ? 762  TYR A N   1 
ATOM   4583 C  CA  . TYR A 1 772 ? 135.099 170.734 145.623 1.00 58.39  ? 762  TYR A CA  1 
ATOM   4584 C  C   . TYR A 1 772 ? 134.987 169.257 145.264 1.00 58.39  ? 762  TYR A C   1 
ATOM   4585 O  O   . TYR A 1 772 ? 135.895 168.466 145.535 1.00 58.39  ? 762  TYR A O   1 
ATOM   4586 C  CB  . TYR A 1 772 ? 135.838 171.475 144.498 1.00 58.39  ? 762  TYR A CB  1 
ATOM   4587 C  CG  . TYR A 1 772 ? 135.968 172.994 144.599 1.00 58.39  ? 762  TYR A CG  1 
ATOM   4588 C  CD1 . TYR A 1 772 ? 135.662 173.687 145.763 1.00 58.39  ? 762  TYR A CD1 1 
ATOM   4589 C  CD2 . TYR A 1 772 ? 136.401 173.732 143.504 1.00 58.39  ? 762  TYR A CD2 1 
ATOM   4590 C  CE1 . TYR A 1 772 ? 135.784 175.058 145.838 1.00 58.39  ? 762  TYR A CE1 1 
ATOM   4591 C  CE2 . TYR A 1 772 ? 136.526 175.107 143.570 1.00 58.39  ? 762  TYR A CE2 1 
ATOM   4592 C  CZ  . TYR A 1 772 ? 136.216 175.763 144.740 1.00 58.39  ? 762  TYR A CZ  1 
ATOM   4593 O  OH  . TYR A 1 772 ? 136.334 177.132 144.818 1.00 58.39  ? 762  TYR A OH  1 
ATOM   4594 N  N   . TRP A 1 773 ? 133.852 168.897 144.653 1.00 60.23  ? 763  TRP A N   1 
ATOM   4595 C  CA  . TRP A 1 773 ? 133.597 167.558 144.109 1.00 60.23  ? 763  TRP A CA  1 
ATOM   4596 C  C   . TRP A 1 773 ? 133.737 166.466 145.165 1.00 60.23  ? 763  TRP A C   1 
ATOM   4597 O  O   . TRP A 1 773 ? 134.189 165.358 144.859 1.00 60.23  ? 763  TRP A O   1 
ATOM   4598 C  CB  . TRP A 1 773 ? 134.513 167.257 142.920 1.00 60.23  ? 763  TRP A CB  1 
ATOM   4599 C  CG  . TRP A 1 773 ? 133.909 167.549 141.584 1.00 60.23  ? 763  TRP A CG  1 
ATOM   4600 C  CD1 . TRP A 1 773 ? 133.649 168.777 141.052 1.00 60.23  ? 763  TRP A CD1 1 
ATOM   4601 C  CD2 . TRP A 1 773 ? 133.507 166.591 140.598 1.00 60.23  ? 763  TRP A CD2 1 
ATOM   4602 N  NE1 . TRP A 1 773 ? 133.101 168.644 139.800 1.00 60.23  ? 763  TRP A NE1 1 
ATOM   4603 C  CE2 . TRP A 1 773 ? 133.004 167.311 139.498 1.00 60.23  ? 763  TRP A CE2 1 
ATOM   4604 C  CE3 . TRP A 1 773 ? 133.519 165.194 140.541 1.00 60.23  ? 763  TRP A CE3 1 
ATOM   4605 C  CZ2 . TRP A 1 773 ? 132.517 166.682 138.354 1.00 60.23  ? 763  TRP A CZ2 1 
ATOM   4606 C  CZ3 . TRP A 1 773 ? 133.036 164.572 139.406 1.00 60.23  ? 763  TRP A CZ3 1 
ATOM   4607 C  CH2 . TRP A 1 773 ? 132.542 165.315 138.328 1.00 60.23  ? 763  TRP A CH2 1 
ATOM   4608 N  N   . ASN A 1 774 ? 133.370 166.785 146.411 1.00 58.30  ? 764  ASN A N   1 
ATOM   4609 C  CA  . ASN A 1 774 ? 133.473 165.868 147.551 1.00 58.30  ? 764  ASN A CA  1 
ATOM   4610 C  C   . ASN A 1 774 ? 134.910 165.383 147.749 1.00 58.30  ? 764  ASN A C   1 
ATOM   4611 O  O   . ASN A 1 774 ? 135.150 164.273 148.230 1.00 58.30  ? 764  ASN A O   1 
ATOM   4612 C  CB  . ASN A 1 774 ? 132.502 164.688 147.402 1.00 58.30  ? 764  ASN A CB  1 
ATOM   4613 C  CG  . ASN A 1 774 ? 132.262 163.952 148.707 1.00 58.30  ? 764  ASN A CG  1 
ATOM   4614 O  OD1 . ASN A 1 774 ? 131.855 164.547 149.704 1.00 58.30  ? 764  ASN A OD1 1 
ATOM   4615 N  ND2 . ASN A 1 774 ? 132.513 162.648 148.704 1.00 58.30  ? 764  ASN A ND2 1 
ATOM   4616 N  N   . GLY A 1 775 ? 135.884 166.212 147.368 1.00 47.70  ? 765  GLY A N   1 
ATOM   4617 C  CA  . GLY A 1 775 ? 137.284 165.874 147.432 1.00 47.70  ? 765  GLY A CA  1 
ATOM   4618 C  C   . GLY A 1 775 ? 137.859 165.369 146.124 1.00 47.70  ? 765  GLY A C   1 
ATOM   4619 O  O   . GLY A 1 775 ? 139.059 165.545 145.878 1.00 47.70  ? 765  GLY A O   1 
ATOM   4620 N  N   . TRP A 1 776 ? 137.017 164.773 145.270 1.00 39.95  ? 766  TRP A N   1 
ATOM   4621 C  CA  . TRP A 1 776 ? 137.497 164.132 144.048 1.00 39.95  ? 766  TRP A CA  1 
ATOM   4622 C  C   . TRP A 1 776 ? 138.192 165.120 143.124 1.00 39.95  ? 766  TRP A C   1 
ATOM   4623 O  O   . TRP A 1 776 ? 139.097 164.731 142.376 1.00 39.95  ? 766  TRP A O   1 
ATOM   4624 C  CB  . TRP A 1 776 ? 136.333 163.465 143.319 1.00 39.95  ? 766  TRP A CB  1 
ATOM   4625 C  CG  . TRP A 1 776 ? 135.834 162.227 143.987 1.00 39.95  ? 766  TRP A CG  1 
ATOM   4626 C  CD1 . TRP A 1 776 ? 134.743 162.120 144.795 1.00 39.95  ? 766  TRP A CD1 1 
ATOM   4627 C  CD2 . TRP A 1 776 ? 136.391 160.912 143.889 1.00 39.95  ? 766  TRP A CD2 1 
ATOM   4628 N  NE1 . TRP A 1 776 ? 134.591 160.823 145.217 1.00 39.95  ? 766  TRP A NE1 1 
ATOM   4629 C  CE2 . TRP A 1 776 ? 135.590 160.060 144.673 1.00 39.95  ? 766  TRP A CE2 1 
ATOM   4630 C  CE3 . TRP A 1 776 ? 137.490 160.372 143.219 1.00 39.95  ? 766  TRP A CE3 1 
ATOM   4631 C  CZ2 . TRP A 1 776 ? 135.853 158.701 144.806 1.00 39.95  ? 766  TRP A CZ2 1 
ATOM   4632 C  CZ3 . TRP A 1 776 ? 137.749 159.021 143.352 1.00 39.95  ? 766  TRP A CZ3 1 
ATOM   4633 C  CH2 . TRP A 1 776 ? 136.935 158.201 144.139 1.00 39.95  ? 766  TRP A CH2 1 
ATOM   4634 N  N   . ALA A 1 777 ? 137.797 166.397 143.179 1.00 41.26  ? 767  ALA A N   1 
ATOM   4635 C  CA  . ALA A 1 777 ? 138.454 167.427 142.383 1.00 41.26  ? 767  ALA A CA  1 
ATOM   4636 C  C   . ALA A 1 777 ? 139.945 167.486 142.679 1.00 41.26  ? 767  ALA A C   1 
ATOM   4637 O  O   . ALA A 1 777 ? 140.760 167.614 141.761 1.00 41.26  ? 767  ALA A O   1 
ATOM   4638 C  CB  . ALA A 1 777 ? 137.808 168.788 142.639 1.00 41.26  ? 767  ALA A CB  1 
ATOM   4639 N  N   . CYS A 1 778 ? 140.323 167.385 143.954 1.00 34.77  ? 768  CYS A N   1 
ATOM   4640 C  CA  . CYS A 1 778 ? 141.742 167.273 144.267 1.00 34.77  ? 768  CYS A CA  1 
ATOM   4641 C  C   . CYS A 1 778 ? 142.293 165.930 143.808 1.00 34.77  ? 768  CYS A C   1 
ATOM   4642 O  O   . CYS A 1 778 ? 143.362 165.872 143.187 1.00 34.77  ? 768  CYS A O   1 
ATOM   4643 C  CB  . CYS A 1 778 ? 141.969 167.470 145.764 1.00 34.77  ? 768  CYS A CB  1 
ATOM   4644 S  SG  . CYS A 1 778 ? 143.704 167.563 146.244 1.00 34.77  ? 768  CYS A SG  1 
ATOM   4645 N  N   . PHE A 1 779 ? 141.531 164.854 144.043 1.00 32.35  ? 769  PHE A N   1 
ATOM   4646 C  CA  . PHE A 1 779 ? 142.034 163.495 143.849 1.00 32.35  ? 769  PHE A CA  1 
ATOM   4647 C  C   . PHE A 1 779 ? 142.450 163.256 142.405 1.00 32.35  ? 769  PHE A C   1 
ATOM   4648 O  O   . PHE A 1 779 ? 143.476 162.620 142.145 1.00 32.35  ? 769  PHE A O   1 
ATOM   4649 C  CB  . PHE A 1 779 ? 140.964 162.487 144.272 1.00 32.35  ? 769  PHE A CB  1 
ATOM   4650 C  CG  . PHE A 1 779 ? 141.340 161.051 144.034 1.00 32.35  ? 769  PHE A CG  1 
ATOM   4651 C  CD1 . PHE A 1 779 ? 142.093 160.362 144.960 1.00 32.35  ? 769  PHE A CD1 1 
ATOM   4652 C  CD2 . PHE A 1 779 ? 140.928 160.388 142.889 1.00 32.35  ? 769  PHE A CD2 1 
ATOM   4653 C  CE1 . PHE A 1 779 ? 142.437 159.041 144.751 1.00 32.35  ? 769  PHE A CE1 1 
ATOM   4654 C  CE2 . PHE A 1 779 ? 141.272 159.069 142.674 1.00 32.35  ? 769  PHE A CE2 1 
ATOM   4655 C  CZ  . PHE A 1 779 ? 142.026 158.396 143.606 1.00 32.35  ? 769  PHE A CZ  1 
ATOM   4656 N  N   . ILE A 1 780 ? 141.661 163.753 141.453 1.00 33.10  ? 770  ILE A N   1 
ATOM   4657 C  CA  . ILE A 1 780 ? 142.005 163.600 140.045 1.00 33.10  ? 770  ILE A CA  1 
ATOM   4658 C  C   . ILE A 1 780 ? 143.193 164.485 139.681 1.00 33.10  ? 770  ILE A C   1 
ATOM   4659 O  O   . ILE A 1 780 ? 144.090 164.066 138.939 1.00 33.10  ? 770  ILE A O   1 
ATOM   4660 C  CB  . ILE A 1 780 ? 140.772 163.892 139.171 1.00 33.10  ? 770  ILE A CB  1 
ATOM   4661 C  CG1 . ILE A 1 780 ? 139.759 162.752 139.293 1.00 33.10  ? 770  ILE A CG1 1 
ATOM   4662 C  CG2 . ILE A 1 780 ? 141.158 164.086 137.713 1.00 33.10  ? 770  ILE A CG2 1 
ATOM   4663 C  CD1 . ILE A 1 780 ? 140.252 161.436 138.733 1.00 33.10  ? 770  ILE A CD1 1 
ATOM   4664 N  N   . VAL A 1 781 ? 143.241 165.707 140.212 1.00 29.86  ? 771  VAL A N   1 
ATOM   4665 C  CA  . VAL A 1 781 ? 144.253 166.649 139.742 1.00 29.86  ? 771  VAL A CA  1 
ATOM   4666 C  C   . VAL A 1 781 ? 145.588 166.404 140.432 1.00 29.86  ? 771  VAL A C   1 
ATOM   4667 O  O   . VAL A 1 781 ? 146.651 166.553 139.818 1.00 29.86  ? 771  VAL A O   1 
ATOM   4668 C  CB  . VAL A 1 781 ? 143.762 168.096 139.928 1.00 29.86  ? 771  VAL A CB  1 
ATOM   4669 C  CG1 . VAL A 1 781 ? 144.809 169.091 139.451 1.00 29.86  ? 771  VAL A CG1 1 
ATOM   4670 C  CG2 . VAL A 1 781 ? 142.478 168.306 139.153 1.00 29.86  ? 771  VAL A CG2 1 
ATOM   4671 N  N   . SER A 1 782 ? 145.561 166.011 141.707 1.00 28.05  ? 772  SER A N   1 
ATOM   4672 C  CA  . SER A 1 782 ? 146.806 165.810 142.442 1.00 28.05  ? 772  SER A CA  1 
ATOM   4673 C  C   . SER A 1 782 ? 147.601 164.629 141.899 1.00 28.05  ? 772  SER A C   1 
ATOM   4674 O  O   . SER A 1 782 ? 148.825 164.722 141.750 1.00 28.05  ? 772  SER A O   1 
ATOM   4675 C  CB  . SER A 1 782 ? 146.517 165.616 143.927 1.00 28.05  ? 772  SER A CB  1 
ATOM   4676 O  OG  . SER A 1 782 ? 147.722 165.525 144.664 1.00 28.05  ? 772  SER A OG  1 
ATOM   4677 N  N   . ILE A 1 783 ? 146.923 163.520 141.579 1.00 25.34  ? 773  ILE A N   1 
ATOM   4678 C  CA  . ILE A 1 783 ? 147.629 162.296 141.198 1.00 25.34  ? 773  ILE A CA  1 
ATOM   4679 C  C   . ILE A 1 783 ? 148.419 162.506 139.911 1.00 25.34  ? 773  ILE A C   1 
ATOM   4680 O  O   . ILE A 1 783 ? 149.568 162.060 139.797 1.00 25.34  ? 773  ILE A O   1 
ATOM   4681 C  CB  . ILE A 1 783 ? 146.651 161.105 141.100 1.00 25.34  ? 773  ILE A CB  1 
ATOM   4682 C  CG1 . ILE A 1 783 ? 147.412 159.813 140.809 1.00 25.34  ? 773  ILE A CG1 1 
ATOM   4683 C  CG2 . ILE A 1 783 ? 145.564 161.328 140.060 1.00 25.34  ? 773  ILE A CG2 1 
ATOM   4684 C  CD1 . ILE A 1 783 ? 148.372 159.426 141.900 1.00 25.34  ? 773  ILE A CD1 1 
ATOM   4685 N  N   . LEU A 1 784 ? 147.840 163.225 138.943 1.00 24.70  ? 774  LEU A N   1 
ATOM   4686 C  CA  . LEU A 1 784 ? 148.583 163.579 137.739 1.00 24.70  ? 774  LEU A CA  1 
ATOM   4687 C  C   . LEU A 1 784 ? 149.795 164.425 138.088 1.00 24.70  ? 774  LEU A C   1 
ATOM   4688 O  O   . LEU A 1 784 ? 150.898 164.181 137.585 1.00 24.70  ? 774  LEU A O   1 
ATOM   4689 C  CB  . LEU A 1 784 ? 147.677 164.323 136.760 1.00 24.70  ? 774  LEU A CB  1 
ATOM   4690 C  CG  . LEU A 1 784 ? 146.429 163.583 136.283 1.00 24.70  ? 774  LEU A CG  1 
ATOM   4691 C  CD1 . LEU A 1 784 ? 145.680 164.414 135.256 1.00 24.70  ? 774  LEU A CD1 1 
ATOM   4692 C  CD2 . LEU A 1 784 ? 146.805 162.229 135.711 1.00 24.70  ? 774  LEU A CD2 1 
ATOM   4693 N  N   . MET A 1 785 ? 149.619 165.385 139.000 1.00 26.70  ? 775  MET A N   1 
ATOM   4694 C  CA  . MET A 1 785 ? 150.737 166.201 139.447 1.00 26.70  ? 775  MET A CA  1 
ATOM   4695 C  C   . MET A 1 785 ? 151.782 165.374 140.182 1.00 26.70  ? 775  MET A C   1 
ATOM   4696 O  O   . MET A 1 785 ? 152.929 165.814 140.306 1.00 26.70  ? 775  MET A O   1 
ATOM   4697 C  CB  . MET A 1 785 ? 150.232 167.342 140.330 1.00 26.70  ? 775  MET A CB  1 
ATOM   4698 C  CG  . MET A 1 785 ? 151.188 168.514 140.426 1.00 26.70  ? 775  MET A CG  1 
ATOM   4699 S  SD  . MET A 1 785 ? 150.817 169.827 139.250 1.00 26.70  ? 775  MET A SD  1 
ATOM   4700 C  CE  . MET A 1 785 ? 149.641 170.801 140.182 1.00 26.70  ? 775  MET A CE  1 
ATOM   4701 N  N   . ILE A 1 786 ? 151.417 164.188 140.672 1.00 22.44  ? 776  ILE A N   1 
ATOM   4702 C  CA  . ILE A 1 786 ? 152.434 163.238 141.104 1.00 22.44  ? 776  ILE A CA  1 
ATOM   4703 C  C   . ILE A 1 786 ? 153.088 162.583 139.898 1.00 22.44  ? 776  ILE A C   1 
ATOM   4704 O  O   . ILE A 1 786 ? 154.313 162.644 139.730 1.00 22.44  ? 776  ILE A O   1 
ATOM   4705 C  CB  . ILE A 1 786 ? 151.831 162.184 142.050 1.00 22.44  ? 776  ILE A CB  1 
ATOM   4706 C  CG1 . ILE A 1 786 ? 151.400 162.820 143.367 1.00 22.44  ? 776  ILE A CG1 1 
ATOM   4707 C  CG2 . ILE A 1 786 ? 152.829 161.084 142.316 1.00 22.44  ? 776  ILE A CG2 1 
ATOM   4708 C  CD1 . ILE A 1 786 ? 150.654 161.876 144.273 1.00 22.44  ? 776  ILE A CD1 1 
ATOM   4709 N  N   . GLY A 1 787 ? 152.269 161.997 139.020 1.00 22.70  ? 777  GLY A N   1 
ATOM   4710 C  CA  . GLY A 1 787 ? 152.725 161.138 137.941 1.00 22.70  ? 777  GLY A CA  1 
ATOM   4711 C  C   . GLY A 1 787 ? 153.778 161.760 137.055 1.00 22.70  ? 777  GLY A C   1 
ATOM   4712 O  O   . GLY A 1 787 ? 154.904 161.253 136.979 1.00 22.70  ? 777  GLY A O   1 
ATOM   4713 N  N   . LEU A 1 788 ? 153.423 162.885 136.426 1.00 23.63  ? 778  LEU A N   1 
ATOM   4714 C  CA  . LEU A 1 788 ? 154.379 163.657 135.639 1.00 23.63  ? 778  LEU A CA  1 
ATOM   4715 C  C   . LEU A 1 788 ? 155.634 163.943 136.448 1.00 23.63  ? 778  LEU A C   1 
ATOM   4716 O  O   . LEU A 1 788 ? 156.751 163.635 136.011 1.00 23.63  ? 778  LEU A O   1 
ATOM   4717 C  CB  . LEU A 1 788 ? 153.725 164.960 135.167 1.00 23.63  ? 778  LEU A CB  1 
ATOM   4718 C  CG  . LEU A 1 788 ? 154.531 165.988 134.368 1.00 23.63  ? 778  LEU A CG  1 
ATOM   4719 C  CD1 . LEU A 1 788 ? 153.645 166.617 133.310 1.00 23.63  ? 778  LEU A CD1 1 
ATOM   4720 C  CD2 . LEU A 1 788 ? 155.105 167.074 135.267 1.00 23.63  ? 778  LEU A CD2 1 
ATOM   4721 N  N   . LEU A 1 789 ? 155.452 164.455 137.670 1.00 24.09  ? 779  LEU A N   1 
ATOM   4722 C  CA  . LEU A 1 789 ? 156.587 164.753 138.535 1.00 24.09  ? 779  LEU A CA  1 
ATOM   4723 C  C   . LEU A 1 789 ? 157.413 163.502 138.777 1.00 24.09  ? 779  LEU A C   1 
ATOM   4724 O  O   . LEU A 1 789 ? 158.645 163.525 138.640 1.00 24.09  ? 779  LEU A O   1 
ATOM   4725 C  CB  . LEU A 1 789 ? 156.088 165.325 139.860 1.00 24.09  ? 779  LEU A CB  1 
ATOM   4726 C  CG  . LEU A 1 789 ? 157.011 166.158 140.744 1.00 24.09  ? 779  LEU A CG  1 
ATOM   4727 C  CD1 . LEU A 1 789 ? 157.317 167.484 140.083 1.00 24.09  ? 779  LEU A CD1 1 
ATOM   4728 C  CD2 . LEU A 1 789 ? 156.360 166.379 142.084 1.00 24.09  ? 779  LEU A CD2 1 
ATOM   4729 N  N   . THR A 1 790 ? 156.736 162.380 139.045 1.00 23.17  ? 780  THR A N   1 
ATOM   4730 C  CA  . THR A 1 790 ? 157.436 161.126 139.291 1.00 23.17  ? 780  THR A CA  1 
ATOM   4731 C  C   . THR A 1 790 ? 158.249 160.719 138.074 1.00 23.17  ? 780  THR A C   1 
ATOM   4732 O  O   . THR A 1 790 ? 159.400 160.279 138.208 1.00 23.17  ? 780  THR A O   1 
ATOM   4733 C  CB  . THR A 1 790 ? 156.437 160.034 139.661 1.00 23.17  ? 780  THR A CB  1 
ATOM   4734 O  OG1 . THR A 1 790 ? 155.647 160.474 140.769 1.00 23.17  ? 780  THR A OG1 1 
ATOM   4735 C  CG2 . THR A 1 790 ? 157.165 158.780 140.061 1.00 23.17  ? 780  THR A CG2 1 
ATOM   4736 N  N   . ALA A 1 791 ? 157.685 160.923 136.876 1.00 24.75  ? 781  ALA A N   1 
ATOM   4737 C  CA  . ALA A 1 791 ? 158.405 160.611 135.647 1.00 24.75  ? 781  ALA A CA  1 
ATOM   4738 C  C   . ALA A 1 791 ? 159.728 161.355 135.594 1.00 24.75  ? 781  ALA A C   1 
ATOM   4739 O  O   . ALA A 1 791 ? 160.768 160.759 135.279 1.00 24.75  ? 781  ALA A O   1 
ATOM   4740 C  CB  . ALA A 1 791 ? 157.548 160.956 134.430 1.00 24.75  ? 781  ALA A CB  1 
ATOM   4741 N  N   . PHE A 1 792 ? 159.714 162.638 135.979 1.00 26.06  ? 782  PHE A N   1 
ATOM   4742 C  CA  . PHE A 1 792 ? 160.935 163.433 135.985 1.00 26.06  ? 782  PHE A CA  1 
ATOM   4743 C  C   . PHE A 1 792 ? 162.002 162.766 136.836 1.00 26.06  ? 782  PHE A C   1 
ATOM   4744 O  O   . PHE A 1 792 ? 163.150 162.605 136.395 1.00 26.06  ? 782  PHE A O   1 
ATOM   4745 C  CB  . PHE A 1 792 ? 160.640 164.842 136.498 1.00 26.06  ? 782  PHE A CB  1 
ATOM   4746 C  CG  . PHE A 1 792 ? 160.372 165.841 135.412 1.00 26.06  ? 782  PHE A CG  1 
ATOM   4747 C  CD1 . PHE A 1 792 ? 159.356 165.631 134.495 1.00 26.06  ? 782  PHE A CD1 1 
ATOM   4748 C  CD2 . PHE A 1 792 ? 161.129 166.994 135.313 1.00 26.06  ? 782  PHE A CD2 1 
ATOM   4749 C  CE1 . PHE A 1 792 ? 159.105 166.550 133.497 1.00 26.06  ? 782  PHE A CE1 1 
ATOM   4750 C  CE2 . PHE A 1 792 ? 160.883 167.916 134.317 1.00 26.06  ? 782  PHE A CE2 1 
ATOM   4751 C  CZ  . PHE A 1 792 ? 159.869 167.693 133.407 1.00 26.06  ? 782  PHE A CZ  1 
ATOM   4752 N  N   . ILE A 1 793 ? 161.605 162.283 138.023 1.00 24.43  ? 783  ILE A N   1 
ATOM   4753 C  CA  . ILE A 1 793 ? 162.545 161.638 138.936 1.00 24.43  ? 783  ILE A CA  1 
ATOM   4754 C  C   . ILE A 1 793 ? 163.243 160.486 138.234 1.00 24.43  ? 783  ILE A C   1 
ATOM   4755 O  O   . ILE A 1 793 ? 164.477 160.381 138.259 1.00 24.43  ? 783  ILE A O   1 
ATOM   4756 C  CB  . ILE A 1 793 ? 161.824 161.159 140.207 1.00 24.43  ? 783  ILE A CB  1 
ATOM   4757 C  CG1 . ILE A 1 793 ? 161.121 162.323 140.900 1.00 24.43  ? 783  ILE A CG1 1 
ATOM   4758 C  CG2 . ILE A 1 793 ? 162.811 160.504 141.156 1.00 24.43  ? 783  ILE A CG2 1 
ATOM   4759 C  CD1 . ILE A 1 793 ? 160.495 161.948 142.224 1.00 24.43  ? 783  ILE A CD1 1 
ATOM   4760 N  N   . GLY A 1 794 ? 162.464 159.669 137.516 1.00 30.96  ? 784  GLY A N   1 
ATOM   4761 C  CA  . GLY A 1 794 ? 163.042 158.525 136.832 1.00 30.96  ? 784  GLY A CA  1 
ATOM   4762 C  C   . GLY A 1 794 ? 164.137 158.937 135.873 1.00 30.96  ? 784  GLY A C   1 
ATOM   4763 O  O   . GLY A 1 794 ? 165.250 158.401 135.920 1.00 30.96  ? 784  GLY A O   1 
ATOM   4764 N  N   . ASP A 1 795 ? 163.872 159.977 135.073 1.00 34.73  ? 785  ASP A N   1 
ATOM   4765 C  CA  . ASP A 1 795 ? 164.869 160.429 134.113 1.00 34.73  ? 785  ASP A CA  1 
ATOM   4766 C  C   . ASP A 1 795 ? 166.123 160.899 134.827 1.00 34.73  ? 785  ASP A C   1 
ATOM   4767 O  O   . ASP A 1 795 ? 167.240 160.539 134.432 1.00 34.73  ? 785  ASP A O   1 
ATOM   4768 C  CB  . ASP A 1 795 ? 164.295 161.532 133.228 1.00 34.73  ? 785  ASP A CB  1 
ATOM   4769 C  CG  . ASP A 1 795 ? 163.301 161.002 132.213 1.00 34.73  ? 785  ASP A CG  1 
ATOM   4770 O  OD1 . ASP A 1 795 ? 162.807 159.870 132.400 1.00 34.73  ? 785  ASP A OD1 1 
ATOM   4771 O  OD2 . ASP A 1 795 ? 163.016 161.713 131.226 1.00 34.73  ? 785  ASP A OD2 1 
ATOM   4772 N  N   . LEU A 1 796 ? 165.955 161.633 135.931 1.00 28.41  ? 786  LEU A N   1 
ATOM   4773 C  CA  . LEU A 1 796 ? 167.117 162.067 136.694 1.00 28.41  ? 786  LEU A CA  1 
ATOM   4774 C  C   . LEU A 1 796 ? 167.869 160.864 137.239 1.00 28.41  ? 786  LEU A C   1 
ATOM   4775 O  O   . LEU A 1 796 ? 169.098 160.781 137.116 1.00 28.41  ? 786  LEU A O   1 
ATOM   4776 C  CB  . LEU A 1 796 ? 166.684 163.003 137.820 1.00 28.41  ? 786  LEU A CB  1 
ATOM   4777 C  CG  . LEU A 1 796 ? 165.987 164.282 137.351 1.00 28.41  ? 786  LEU A CG  1 
ATOM   4778 C  CD1 . LEU A 1 796 ? 165.415 165.049 138.528 1.00 28.41  ? 786  LEU A CD1 1 
ATOM   4779 C  CD2 . LEU A 1 796 ? 166.934 165.154 136.554 1.00 28.41  ? 786  LEU A CD2 1 
ATOM   4780 N  N   . ALA A 1 797 ? 167.132 159.877 137.757 1.00 34.39  ? 787  ALA A N   1 
ATOM   4781 C  CA  . ALA A 1 797 ? 167.781 158.683 138.279 1.00 34.39  ? 787  ALA A CA  1 
ATOM   4782 C  C   . ALA A 1 797 ? 168.418 157.872 137.164 1.00 34.39  ? 787  ALA A C   1 
ATOM   4783 O  O   . ALA A 1 797 ? 169.339 157.087 137.417 1.00 34.39  ? 787  ALA A O   1 
ATOM   4784 C  CB  . ALA A 1 797 ? 166.778 157.836 139.058 1.00 34.39  ? 787  ALA A CB  1 
ATOM   4785 N  N   . SER A 1 798 ? 167.948 158.047 135.928 1.00 37.57  ? 788  SER A N   1 
ATOM   4786 C  CA  . SER A 1 798 ? 168.579 157.355 134.815 1.00 37.57  ? 788  SER A CA  1 
ATOM   4787 C  C   . SER A 1 798 ? 169.853 158.054 134.370 1.00 37.57  ? 788  SER A C   1 
ATOM   4788 O  O   . SER A 1 798 ? 170.719 157.418 133.760 1.00 37.57  ? 788  SER A O   1 
ATOM   4789 C  CB  . SER A 1 798 ? 167.603 157.233 133.645 1.00 37.57  ? 788  SER A CB  1 
ATOM   4790 O  OG  . SER A 1 798 ? 168.052 156.267 132.713 1.00 37.57  ? 788  SER A OG  1 
ATOM   4791 N  N   . HIS A 1 799 ? 169.992 159.348 134.661 1.00 43.98  ? 789  HIS A N   1 
ATOM   4792 C  CA  . HIS A 1 799 ? 171.128 160.107 134.153 1.00 43.98  ? 789  HIS A CA  1 
ATOM   4793 C  C   . HIS A 1 799 ? 172.225 160.312 135.185 1.00 43.98  ? 789  HIS A C   1 
ATOM   4794 O  O   . HIS A 1 799 ? 173.408 160.186 134.849 1.00 43.98  ? 789  HIS A O   1 
ATOM   4795 C  CB  . HIS A 1 799 ? 170.663 161.460 133.612 1.00 43.98  ? 789  HIS A CB  1 
ATOM   4796 C  CG  . HIS A 1 799 ? 169.871 161.356 132.348 1.00 43.98  ? 789  HIS A CG  1 
ATOM   4797 N  ND1 . HIS A 1 799 ? 169.043 162.362 131.902 1.00 43.98  ? 789  HIS A ND1 1 
ATOM   4798 C  CD2 . HIS A 1 799 ? 169.776 160.358 131.439 1.00 43.98  ? 789  HIS A CD2 1 
ATOM   4799 C  CE1 . HIS A 1 799 ? 168.474 161.990 130.770 1.00 43.98  ? 789  HIS A CE1 1 
ATOM   4800 N  NE2 . HIS A 1 799 ? 168.902 160.778 130.467 1.00 43.98  ? 789  HIS A NE2 1 
ATOM   4801 N  N   . PHE A 1 800 ? 171.867 160.609 136.437 1.00 45.98  ? 790  PHE A N   1 
ATOM   4802 C  CA  . PHE A 1 800 ? 172.874 160.686 137.490 1.00 45.98  ? 790  PHE A CA  1 
ATOM   4803 C  C   . PHE A 1 800 ? 173.606 159.360 137.649 1.00 45.98  ? 790  PHE A C   1 
ATOM   4804 O  O   . PHE A 1 800 ? 174.770 159.336 138.064 1.00 45.98  ? 790  PHE A O   1 
ATOM   4805 C  CB  . PHE A 1 800 ? 172.222 161.115 138.807 1.00 45.98  ? 790  PHE A CB  1 
ATOM   4806 C  CG  . PHE A 1 800 ? 173.151 161.080 139.989 1.00 45.98  ? 790  PHE A CG  1 
ATOM   4807 C  CD1 . PHE A 1 800 ? 174.010 162.135 140.240 1.00 45.98  ? 790  PHE A CD1 1 
ATOM   4808 C  CD2 . PHE A 1 800 ? 173.147 160.006 140.863 1.00 45.98  ? 790  PHE A CD2 1 
ATOM   4809 C  CE1 . PHE A 1 800 ? 174.861 162.112 141.324 1.00 45.98  ? 790  PHE A CE1 1 
ATOM   4810 C  CE2 . PHE A 1 800 ? 173.995 159.978 141.948 1.00 45.98  ? 790  PHE A CE2 1 
ATOM   4811 C  CZ  . PHE A 1 800 ? 174.852 161.033 142.179 1.00 45.98  ? 790  PHE A CZ  1 
ATOM   4812 N  N   . GLY A 1 801 ? 172.943 158.250 137.324 1.00 56.20  ? 791  GLY A N   1 
ATOM   4813 C  CA  . GLY A 1 801 ? 173.638 156.977 137.270 1.00 56.20  ? 791  GLY A CA  1 
ATOM   4814 C  C   . GLY A 1 801 ? 174.660 156.912 136.149 1.00 56.20  ? 791  GLY A C   1 
ATOM   4815 O  O   . GLY A 1 801 ? 175.787 156.452 136.351 1.00 56.20  ? 791  GLY A O   1 
ATOM   4816 N  N   . CYS A 1 802 ? 174.286 157.376 134.951 1.00 64.66  ? 792  CYS A N   1 
ATOM   4817 C  CA  . CYS A 1 802 ? 175.163 157.178 133.801 1.00 64.66  ? 792  CYS A CA  1 
ATOM   4818 C  C   . CYS A 1 802 ? 176.295 158.195 133.754 1.00 64.66  ? 792  CYS A C   1 
ATOM   4819 O  O   . CYS A 1 802 ? 177.365 157.894 133.213 1.00 64.66  ? 792  CYS A O   1 
ATOM   4820 C  CB  . CYS A 1 802 ? 174.369 157.231 132.494 1.00 64.66  ? 792  CYS A CB  1 
ATOM   4821 S  SG  . CYS A 1 802 ? 173.791 158.869 132.015 1.00 64.66  ? 792  CYS A SG  1 
ATOM   4822 N  N   . THR A 1 803 ? 176.079 159.397 134.292 1.00 60.56  ? 793  THR A N   1 
ATOM   4823 C  CA  . THR A 1 803 ? 177.121 160.419 134.279 1.00 60.56  ? 793  THR A CA  1 
ATOM   4824 C  C   . THR A 1 803 ? 178.290 160.027 135.177 1.00 60.56  ? 793  THR A C   1 
ATOM   4825 O  O   . THR A 1 803 ? 179.453 160.095 134.764 1.00 60.56  ? 793  THR A O   1 
ATOM   4826 C  CB  . THR A 1 803 ? 176.532 161.764 134.708 1.00 60.56  ? 793  THR A CB  1 
ATOM   4827 O  OG1 . THR A 1 803 ? 175.683 162.266 133.669 1.00 60.56  ? 793  THR A OG1 1 
ATOM   4828 C  CG2 . THR A 1 803 ? 177.631 162.771 134.983 1.00 60.56  ? 793  THR A CG2 1 
ATOM   4829 N  N   . ILE A 1 804 ? 177.998 159.597 136.405 1.00 57.92  ? 794  ILE A N   1 
ATOM   4830 C  CA  . ILE A 1 804 ? 179.054 159.169 137.315 1.00 57.92  ? 794  ILE A CA  1 
ATOM   4831 C  C   . ILE A 1 804 ? 179.530 157.754 137.003 1.00 57.92  ? 794  ILE A C   1 
ATOM   4832 O  O   . ILE A 1 804 ? 180.724 157.458 137.149 1.00 57.92  ? 794  ILE A O   1 
ATOM   4833 C  CB  . ILE A 1 804 ? 178.553 159.293 138.767 1.00 57.92  ? 794  ILE A CB  1 
ATOM   4834 C  CG1 . ILE A 1 804 ? 178.339 160.764 139.123 1.00 57.92  ? 794  ILE A CG1 1 
ATOM   4835 C  CG2 . ILE A 1 804 ? 179.517 158.654 139.763 1.00 57.92  ? 794  ILE A CG2 1 
ATOM   4836 C  CD1 . ILE A 1 804 ? 179.627 161.530 139.346 1.00 57.92  ? 794  ILE A CD1 1 
ATOM   4837 N  N   . GLY A 1 805 ? 178.648 156.892 136.507 1.00 54.48  ? 795  GLY A N   1 
ATOM   4838 C  CA  . GLY A 1 805 ? 178.987 155.498 136.308 1.00 54.48  ? 795  GLY A CA  1 
ATOM   4839 C  C   . GLY A 1 805 ? 178.483 154.638 137.446 1.00 54.48  ? 795  GLY A C   1 
ATOM   4840 O  O   . GLY A 1 805 ? 179.129 153.665 137.846 1.00 54.48  ? 795  GLY A O   1 
ATOM   4841 N  N   . LEU A 1 806 ? 177.318 154.999 137.974 1.00 47.07  ? 796  LEU A N   1 
ATOM   4842 C  CA  . LEU A 1 806 ? 176.682 154.282 139.068 1.00 47.07  ? 796  LEU A CA  1 
ATOM   4843 C  C   . LEU A 1 806 ? 175.537 153.447 138.513 1.00 47.07  ? 796  LEU A C   1 
ATOM   4844 O  O   . LEU A 1 806 ? 174.724 153.948 137.730 1.00 47.07  ? 796  LEU A O   1 
ATOM   4845 C  CB  . LEU A 1 806 ? 176.167 155.261 140.124 1.00 47.07  ? 796  LEU A CB  1 
ATOM   4846 C  CG  . LEU A 1 806 ? 175.980 154.761 141.555 1.00 47.07  ? 796  LEU A CG  1 
ATOM   4847 C  CD1 . LEU A 1 806 ? 177.258 154.134 142.077 1.00 47.07  ? 796  LEU A CD1 1 
ATOM   4848 C  CD2 . LEU A 1 806 ? 175.543 155.907 142.451 1.00 47.07  ? 796  LEU A CD2 1 
ATOM   4849 N  N   . LYS A 1 807 ? 175.484 152.178 138.905 1.00 43.81  ? 797  LYS A N   1 
ATOM   4850 C  CA  . LYS A 1 807 ? 174.453 151.286 138.398 1.00 43.81  ? 797  LYS A CA  1 
ATOM   4851 C  C   . LYS A 1 807 ? 173.080 151.704 138.912 1.00 43.81  ? 797  LYS A C   1 
ATOM   4852 O  O   . LYS A 1 807 ? 172.953 152.357 139.952 1.00 43.81  ? 797  LYS A O   1 
ATOM   4853 C  CB  . LYS A 1 807 ? 174.751 149.842 138.797 1.00 43.81  ? 797  LYS A CB  1 
ATOM   4854 C  CG  . LYS A 1 807 ? 175.602 149.094 137.785 1.00 43.81  ? 797  LYS A CG  1 
ATOM   4855 C  CD  . LYS A 1 807 ? 175.544 147.595 138.008 1.00 43.81  ? 797  LYS A CD  1 
ATOM   4856 C  CE  . LYS A 1 807 ? 176.287 146.850 136.912 1.00 43.81  ? 797  LYS A CE  1 
ATOM   4857 N  NZ  . LYS A 1 807 ? 175.597 146.959 135.598 1.00 43.81  ? 797  LYS A NZ  1 
ATOM   4858 N  N   . ASP A 1 808 ? 172.044 151.331 138.157 1.00 38.40  ? 798  ASP A N   1 
ATOM   4859 C  CA  . ASP A 1 808 ? 170.690 151.765 138.487 1.00 38.40  ? 798  ASP A CA  1 
ATOM   4860 C  C   . ASP A 1 808 ? 170.178 151.117 139.767 1.00 38.40  ? 798  ASP A C   1 
ATOM   4861 O  O   . ASP A 1 808 ? 169.345 151.707 140.464 1.00 38.40  ? 798  ASP A O   1 
ATOM   4862 C  CB  . ASP A 1 808 ? 169.747 151.469 137.323 1.00 38.40  ? 798  ASP A CB  1 
ATOM   4863 C  CG  . ASP A 1 808 ? 169.799 152.537 136.252 1.00 38.40  ? 798  ASP A CG  1 
ATOM   4864 O  OD1 . ASP A 1 808 ? 170.883 153.124 136.052 1.00 38.40  ? 798  ASP A OD1 1 
ATOM   4865 O  OD2 . ASP A 1 808 ? 168.761 152.792 135.608 1.00 38.40  ? 798  ASP A OD2 1 
ATOM   4866 N  N   . SER A 1 809 ? 170.663 149.917 140.093 1.00 31.59  ? 799  SER A N   1 
ATOM   4867 C  CA  . SER A 1 809 ? 170.252 149.265 141.332 1.00 31.59  ? 799  SER A CA  1 
ATOM   4868 C  C   . SER A 1 809 ? 170.692 150.061 142.554 1.00 31.59  ? 799  SER A C   1 
ATOM   4869 O  O   . SER A 1 809 ? 169.911 150.251 143.493 1.00 31.59  ? 799  SER A O   1 
ATOM   4870 C  CB  . SER A 1 809 ? 170.815 147.846 141.388 1.00 31.59  ? 799  SER A CB  1 
ATOM   4871 O  OG  . SER A 1 809 ? 170.506 147.129 140.208 1.00 31.59  ? 799  SER A OG  1 
ATOM   4872 N  N   . VAL A 1 810 ? 171.933 150.552 142.552 1.00 30.15  ? 800  VAL A N   1 
ATOM   4873 C  CA  . VAL A 1 810 ? 172.449 151.283 143.707 1.00 30.15  ? 800  VAL A CA  1 
ATOM   4874 C  C   . VAL A 1 810 ? 171.710 152.606 143.884 1.00 30.15  ? 800  VAL A C   1 
ATOM   4875 O  O   . VAL A 1 810 ? 171.242 152.931 144.983 1.00 30.15  ? 800  VAL A O   1 
ATOM   4876 C  CB  . VAL A 1 810 ? 173.966 151.496 143.568 1.00 30.15  ? 800  VAL A CB  1 
ATOM   4877 C  CG1 . VAL A 1 810 ? 174.441 152.595 144.502 1.00 30.15  ? 800  VAL A CG1 1 
ATOM   4878 C  CG2 . VAL A 1 810 ? 174.704 150.199 143.846 1.00 30.15  ? 800  VAL A CG2 1 
ATOM   4879 N  N   . THR A 1 811 ? 171.577 153.380 142.801 1.00 23.94  ? 801  THR A N   1 
ATOM   4880 C  CA  . THR A 1 811 ? 170.885 154.661 142.888 1.00 23.94  ? 801  THR A CA  1 
ATOM   4881 C  C   . THR A 1 811 ? 169.390 154.496 143.122 1.00 23.94  ? 801  THR A C   1 
ATOM   4882 O  O   . THR A 1 811 ? 168.736 155.450 143.552 1.00 23.94  ? 801  THR A O   1 
ATOM   4883 C  CB  . THR A 1 811 ? 171.131 155.496 141.629 1.00 23.94  ? 801  THR A CB  1 
ATOM   4884 O  OG1 . THR A 1 811 ? 170.628 156.821 141.831 1.00 23.94  ? 801  THR A OG1 1 
ATOM   4885 C  CG2 . THR A 1 811 ? 170.441 154.887 140.428 1.00 23.94  ? 801  THR A CG2 1 
ATOM   4886 N  N   . ALA A 1 812 ? 168.832 153.316 142.843 1.00 21.97  ? 802  ALA A N   1 
ATOM   4887 C  CA  . ALA A 1 812 ? 167.475 153.028 143.288 1.00 21.97  ? 802  ALA A CA  1 
ATOM   4888 C  C   . ALA A 1 812 ? 167.437 152.745 144.782 1.00 21.97  ? 802  ALA A C   1 
ATOM   4889 O  O   . ALA A 1 812 ? 166.513 153.178 145.478 1.00 21.97  ? 802  ALA A O   1 
ATOM   4890 C  CB  . ALA A 1 812 ? 166.906 151.846 142.511 1.00 21.97  ? 802  ALA A CB  1 
ATOM   4891 N  N   . VAL A 1 813 ? 168.425 152.005 145.287 1.00 21.48  ? 803  VAL A N   1 
ATOM   4892 C  CA  . VAL A 1 813 ? 168.395 151.570 146.680 1.00 21.48  ? 803  VAL A CA  1 
ATOM   4893 C  C   . VAL A 1 813 ? 168.603 152.748 147.627 1.00 21.48  ? 803  VAL A C   1 
ATOM   4894 O  O   . VAL A 1 813 ? 167.856 152.916 148.598 1.00 21.48  ? 803  VAL A O   1 
ATOM   4895 C  CB  . VAL A 1 813 ? 169.433 150.459 146.916 1.00 21.48  ? 803  VAL A CB  1 
ATOM   4896 C  CG1 . VAL A 1 813 ? 169.768 150.337 148.390 1.00 21.48  ? 803  VAL A CG1 1 
ATOM   4897 C  CG2 . VAL A 1 813 ? 168.909 149.134 146.393 1.00 21.48  ? 803  VAL A CG2 1 
ATOM   4898 N  N   . VAL A 1 814 ? 169.601 153.589 147.365 1.00 21.66  ? 804  VAL A N   1 
ATOM   4899 C  CA  . VAL A 1 814 ? 169.975 154.565 148.390 1.00 21.66  ? 804  VAL A CA  1 
ATOM   4900 C  C   . VAL A 1 814 ? 169.306 155.922 148.177 1.00 21.66  ? 804  VAL A C   1 
ATOM   4901 O  O   . VAL A 1 814 ? 168.895 156.565 149.145 1.00 21.66  ? 804  VAL A O   1 
ATOM   4902 C  CB  . VAL A 1 814 ? 171.510 154.699 148.497 1.00 21.66  ? 804  VAL A CB  1 
ATOM   4903 C  CG1 . VAL A 1 814 ? 172.111 153.427 149.068 1.00 21.66  ? 804  VAL A CG1 1 
ATOM   4904 C  CG2 . VAL A 1 814 ? 172.136 155.035 147.166 1.00 21.66  ? 804  VAL A CG2 1 
ATOM   4905 N  N   . PHE A 1 815 ? 169.170 156.403 146.940 1.00 22.95  ? 805  PHE A N   1 
ATOM   4906 C  CA  . PHE A 1 815 ? 168.675 157.759 146.709 1.00 22.95  ? 805  PHE A CA  1 
ATOM   4907 C  C   . PHE A 1 815 ? 167.169 157.812 146.471 1.00 22.95  ? 805  PHE A C   1 
ATOM   4908 O  O   . PHE A 1 815 ? 166.451 158.491 147.210 1.00 22.95  ? 805  PHE A O   1 
ATOM   4909 C  CB  . PHE A 1 815 ? 169.415 158.408 145.531 1.00 22.95  ? 805  PHE A CB  1 
ATOM   4910 C  CG  . PHE A 1 815 ? 170.892 158.560 145.751 1.00 22.95  ? 805  PHE A CG  1 
ATOM   4911 C  CD1 . PHE A 1 815 ? 171.377 159.466 146.678 1.00 22.95  ? 805  PHE A CD1 1 
ATOM   4912 C  CD2 . PHE A 1 815 ? 171.797 157.813 145.016 1.00 22.95  ? 805  PHE A CD2 1 
ATOM   4913 C  CE1 . PHE A 1 815 ? 172.736 159.610 146.882 1.00 22.95  ? 805  PHE A CE1 1 
ATOM   4914 C  CE2 . PHE A 1 815 ? 173.157 157.953 145.215 1.00 22.95  ? 805  PHE A CE2 1 
ATOM   4915 C  CZ  . PHE A 1 815 ? 173.627 158.852 146.148 1.00 22.95  ? 805  PHE A CZ  1 
ATOM   4916 N  N   . VAL A 1 816 ? 166.678 157.115 145.444 1.00 19.80  ? 806  VAL A N   1 
ATOM   4917 C  CA  . VAL A 1 816 ? 165.275 157.247 145.054 1.00 19.80  ? 806  VAL A CA  1 
ATOM   4918 C  C   . VAL A 1 816 ? 164.357 156.629 146.104 1.00 19.80  ? 806  VAL A C   1 
ATOM   4919 O  O   . VAL A 1 816 ? 163.268 157.150 146.380 1.00 19.80  ? 806  VAL A O   1 
ATOM   4920 C  CB  . VAL A 1 816 ? 165.053 156.630 143.662 1.00 19.80  ? 806  VAL A CB  1 
ATOM   4921 C  CG1 . VAL A 1 816 ? 163.592 156.698 143.266 1.00 19.80  ? 806  VAL A CG1 1 
ATOM   4922 C  CG2 . VAL A 1 816 ? 165.904 157.345 142.638 1.00 19.80  ? 806  VAL A CG2 1 
ATOM   4923 N  N   . ALA A 1 817 ? 164.777 155.513 146.704 1.00 18.87  ? 807  ALA A N   1 
ATOM   4924 C  CA  . ALA A 1 817 ? 163.961 154.870 147.730 1.00 18.87  ? 807  ALA A CA  1 
ATOM   4925 C  C   . ALA A 1 817 ? 163.783 155.773 148.943 1.00 18.87  ? 807  ALA A C   1 
ATOM   4926 O  O   . ALA A 1 817 ? 162.702 155.813 149.540 1.00 18.87  ? 807  ALA A O   1 
ATOM   4927 C  CB  . ALA A 1 817 ? 164.584 153.540 148.142 1.00 18.87  ? 807  ALA A CB  1 
ATOM   4928 N  N   . LEU A 1 818 ? 164.833 156.500 149.326 1.00 17.98  ? 808  LEU A N   1 
ATOM   4929 C  CA  . LEU A 1 818 ? 164.714 157.445 150.432 1.00 17.98  ? 808  LEU A CA  1 
ATOM   4930 C  C   . LEU A 1 818 ? 163.839 158.632 150.048 1.00 17.98  ? 808  LEU A C   1 
ATOM   4931 O  O   . LEU A 1 818 ? 163.093 159.156 150.882 1.00 17.98  ? 808  LEU A O   1 
ATOM   4932 C  CB  . LEU A 1 818 ? 166.104 157.912 150.869 1.00 17.98  ? 808  LEU A CB  1 
ATOM   4933 C  CG  . LEU A 1 818 ? 166.365 158.292 152.332 1.00 17.98  ? 808  LEU A CG  1 
ATOM   4934 C  CD1 . LEU A 1 818 ? 167.861 158.312 152.601 1.00 17.98  ? 808  LEU A CD1 1 
ATOM   4935 C  CD2 . LEU A 1 818 ? 165.755 159.633 152.705 1.00 17.98  ? 808  LEU A CD2 1 
ATOM   4936 N  N   . GLY A 1 819 ? 163.917 159.071 148.792 1.00 17.29  ? 809  GLY A N   1 
ATOM   4937 C  CA  . GLY A 1 819 ? 163.173 160.248 148.383 1.00 17.29  ? 809  GLY A CA  1 
ATOM   4938 C  C   . GLY A 1 819 ? 161.687 160.011 148.209 1.00 17.29  ? 809  GLY A C   1 
ATOM   4939 O  O   . GLY A 1 819 ? 160.880 160.899 148.492 1.00 17.29  ? 809  GLY A O   1 
ATOM   4940 N  N   . THR A 1 820 ? 161.300 158.824 147.747 1.00 16.98  ? 810  THR A N   1 
ATOM   4941 C  CA  . THR A 1 820 ? 159.899 158.536 147.471 1.00 16.98  ? 810  THR A CA  1 
ATOM   4942 C  C   . THR A 1 820 ? 159.183 157.869 148.636 1.00 16.98  ? 810  THR A C   1 
ATOM   4943 O  O   . THR A 1 820 ? 157.990 157.575 148.522 1.00 16.98  ? 810  THR A O   1 
ATOM   4944 C  CB  . THR A 1 820 ? 159.768 157.657 146.225 1.00 16.98  ? 810  THR A CB  1 
ATOM   4945 O  OG1 . THR A 1 820 ? 160.388 156.390 146.467 1.00 16.98  ? 810  THR A OG1 1 
ATOM   4946 C  CG2 . THR A 1 820 ? 160.428 158.320 145.033 1.00 16.98  ? 810  THR A CG2 1 
ATOM   4947 N  N   . SER A 1 821 ? 159.872 157.620 149.748 1.00 17.44  ? 811  SER A N   1 
ATOM   4948 C  CA  . SER A 1 821 ? 159.248 157.054 150.935 1.00 17.44  ? 811  SER A CA  1 
ATOM   4949 C  C   . SER A 1 821 ? 159.136 158.059 152.072 1.00 17.44  ? 811  SER A C   1 
ATOM   4950 O  O   . SER A 1 821 ? 158.761 157.681 153.185 1.00 17.44  ? 811  SER A O   1 
ATOM   4951 C  CB  . SER A 1 821 ? 160.020 155.822 151.402 1.00 17.44  ? 811  SER A CB  1 
ATOM   4952 O  OG  . SER A 1 821 ? 160.058 154.841 150.383 1.00 17.44  ? 811  SER A OG  1 
ATOM   4953 N  N   . VAL A 1 822 ? 159.467 159.323 151.826 1.00 17.91  ? 812  VAL A N   1 
ATOM   4954 C  CA  . VAL A 1 822 ? 159.294 160.382 152.818 1.00 17.91  ? 812  VAL A CA  1 
ATOM   4955 C  C   . VAL A 1 822 ? 157.824 160.762 153.045 1.00 17.91  ? 812  VAL A C   1 
ATOM   4956 O  O   . VAL A 1 822 ? 157.515 161.220 154.154 1.00 17.91  ? 812  VAL A O   1 
ATOM   4957 C  CB  . VAL A 1 822 ? 160.179 161.603 152.482 1.00 17.91  ? 812  VAL A CB  1 
ATOM   4958 C  CG1 . VAL A 1 822 ? 159.707 162.373 151.264 1.00 17.91  ? 812  VAL A CG1 1 
ATOM   4959 C  CG2 . VAL A 1 822 ? 160.345 162.520 153.690 1.00 17.91  ? 812  VAL A CG2 1 
ATOM   4960 N  N   . PRO A 1 823 ? 156.868 160.625 152.102 1.00 18.47  ? 813  PRO A N   1 
ATOM   4961 C  CA  . PRO A 1 823 ? 155.465 160.827 152.510 1.00 18.47  ? 813  PRO A CA  1 
ATOM   4962 C  C   . PRO A 1 823 ? 154.945 159.771 153.472 1.00 18.47  ? 813  PRO A C   1 
ATOM   4963 O  O   . PRO A 1 823 ? 154.002 160.056 154.219 1.00 18.47  ? 813  PRO A O   1 
ATOM   4964 C  CB  . PRO A 1 823 ? 154.694 160.793 151.185 1.00 18.47  ? 813  PRO A CB  1 
ATOM   4965 C  CG  . PRO A 1 823 ? 155.683 161.093 150.164 1.00 18.47  ? 813  PRO A CG  1 
ATOM   4966 C  CD  . PRO A 1 823 ? 156.921 160.434 150.637 1.00 18.47  ? 813  PRO A CD  1 
ATOM   4967 N  N   . ASP A 1 824 ? 155.517 158.564 153.475 1.00 20.49  ? 814  ASP A N   1 
ATOM   4968 C  CA  . ASP A 1 824 ? 155.056 157.513 154.378 1.00 20.49  ? 814  ASP A CA  1 
ATOM   4969 C  C   . ASP A 1 824 ? 155.505 157.757 155.814 1.00 20.49  ? 814  ASP A C   1 
ATOM   4970 O  O   . ASP A 1 824 ? 154.755 157.471 156.760 1.00 20.49  ? 814  ASP A O   1 
ATOM   4971 C  CB  . ASP A 1 824 ? 155.564 156.152 153.901 1.00 20.49  ? 814  ASP A CB  1 
ATOM   4972 C  CG  . ASP A 1 824 ? 154.964 155.733 152.575 1.00 20.49  ? 814  ASP A CG  1 
ATOM   4973 O  OD1 . ASP A 1 824 ? 153.814 155.250 152.572 1.00 20.49  ? 814  ASP A OD1 1 
ATOM   4974 O  OD2 . ASP A 1 824 ? 155.638 155.881 151.535 1.00 20.49  ? 814  ASP A OD2 1 
ATOM   4975 N  N   . THR A 1 825 ? 156.727 158.269 155.993 1.00 20.21  ? 815  THR A N   1 
ATOM   4976 C  CA  . THR A 1 825 ? 157.288 158.379 157.333 1.00 20.21  ? 815  THR A CA  1 
ATOM   4977 C  C   . THR A 1 825 ? 156.559 159.419 158.172 1.00 20.21  ? 815  THR A C   1 
ATOM   4978 O  O   . THR A 1 825 ? 156.462 159.258 159.391 1.00 20.21  ? 815  THR A O   1 
ATOM   4979 C  CB  . THR A 1 825 ? 158.791 158.681 157.268 1.00 20.21  ? 815  THR A CB  1 
ATOM   4980 O  OG1 . THR A 1 825 ? 159.364 158.531 158.570 1.00 20.21  ? 815  THR A OG1 1 
ATOM   4981 C  CG2 . THR A 1 825 ? 159.076 160.081 156.760 1.00 20.21  ? 815  THR A CG2 1 
ATOM   4982 N  N   . PHE A 1 826 ? 155.999 160.458 157.547 1.00 21.10  ? 816  PHE A N   1 
ATOM   4983 C  CA  . PHE A 1 826 ? 155.259 161.454 158.314 1.00 21.10  ? 816  PHE A CA  1 
ATOM   4984 C  C   . PHE A 1 826 ? 153.955 160.878 158.844 1.00 21.10  ? 816  PHE A C   1 
ATOM   4985 O  O   . PHE A 1 826 ? 153.600 161.102 160.009 1.00 21.10  ? 816  PHE A O   1 
ATOM   4986 C  CB  . PHE A 1 826 ? 154.999 162.690 157.459 1.00 21.10  ? 816  PHE A CB  1 
ATOM   4987 C  CG  . PHE A 1 826 ? 156.206 163.560 157.279 1.00 21.10  ? 816  PHE A CG  1 
ATOM   4988 C  CD1 . PHE A 1 826 ? 157.053 163.814 158.344 1.00 21.10  ? 816  PHE A CD1 1 
ATOM   4989 C  CD2 . PHE A 1 826 ? 156.493 164.124 156.049 1.00 21.10  ? 816  PHE A CD2 1 
ATOM   4990 C  CE1 . PHE A 1 826 ? 158.167 164.613 158.185 1.00 21.10  ? 816  PHE A CE1 1 
ATOM   4991 C  CE2 . PHE A 1 826 ? 157.605 164.926 155.883 1.00 21.10  ? 816  PHE A CE2 1 
ATOM   4992 C  CZ  . PHE A 1 826 ? 158.443 165.170 156.953 1.00 21.10  ? 816  PHE A CZ  1 
ATOM   4993 N  N   . ALA A 1 827 ? 153.238 160.121 158.010 1.00 22.92  ? 817  ALA A N   1 
ATOM   4994 C  CA  . ALA A 1 827 ? 152.020 159.463 158.468 1.00 22.92  ? 817  ALA A CA  1 
ATOM   4995 C  C   . ALA A 1 827 ? 152.320 158.463 159.574 1.00 22.92  ? 817  ALA A C   1 
ATOM   4996 O  O   . ALA A 1 827 ? 151.609 158.418 160.587 1.00 22.92  ? 817  ALA A O   1 
ATOM   4997 C  CB  . ALA A 1 827 ? 151.324 158.767 157.302 1.00 22.92  ? 817  ALA A CB  1 
ATOM   4998 N  N   . SER A 1 828 ? 153.380 157.666 159.408 1.00 24.04  ? 818  SER A N   1 
ATOM   4999 C  CA  . SER A 1 828 ? 153.727 156.689 160.436 1.00 24.04  ? 818  SER A CA  1 
ATOM   5000 C  C   . SER A 1 828 ? 154.127 157.368 161.742 1.00 24.04  ? 818  SER A C   1 
ATOM   5001 O  O   . SER A 1 828 ? 153.727 156.926 162.825 1.00 24.04  ? 818  SER A O   1 
ATOM   5002 C  CB  . SER A 1 828 ? 154.843 155.774 159.940 1.00 24.04  ? 818  SER A CB  1 
ATOM   5003 O  OG  . SER A 1 828 ? 154.383 154.933 158.898 1.00 24.04  ? 818  SER A OG  1 
ATOM   5004 N  N   . LYS A 1 829 ? 154.895 158.459 161.660 1.00 25.74  ? 819  LYS A N   1 
ATOM   5005 C  CA  . LYS A 1 829 ? 155.332 159.162 162.861 1.00 25.74  ? 819  LYS A CA  1 
ATOM   5006 C  C   . LYS A 1 829 ? 154.162 159.806 163.595 1.00 25.74  ? 819  LYS A C   1 
ATOM   5007 O  O   . LYS A 1 829 ? 154.066 159.706 164.824 1.00 25.74  ? 819  LYS A O   1 
ATOM   5008 C  CB  . LYS A 1 829 ? 156.381 160.208 162.488 1.00 25.74  ? 819  LYS A CB  1 
ATOM   5009 C  CG  . LYS A 1 829 ? 156.499 161.370 163.450 1.00 25.74  ? 819  LYS A CG  1 
ATOM   5010 C  CD  . LYS A 1 829 ? 157.831 162.075 163.275 1.00 25.74  ? 819  LYS A CD  1 
ATOM   5011 C  CE  . LYS A 1 829 ? 157.748 163.527 163.706 1.00 25.74  ? 819  LYS A CE  1 
ATOM   5012 N  NZ  . LYS A 1 829 ? 157.070 163.673 165.022 1.00 25.74  ? 819  LYS A NZ  1 
ATOM   5013 N  N   . VAL A 1 830 ? 153.255 160.460 162.862 1.00 26.94  ? 820  VAL A N   1 
ATOM   5014 C  CA  . VAL A 1 830 ? 152.102 161.089 163.503 1.00 26.94  ? 820  VAL A CA  1 
ATOM   5015 C  C   . VAL A 1 830 ? 151.185 160.036 164.115 1.00 26.94  ? 820  VAL A C   1 
ATOM   5016 O  O   . VAL A 1 830 ? 150.684 160.206 165.237 1.00 26.94  ? 820  VAL A O   1 
ATOM   5017 C  CB  . VAL A 1 830 ? 151.358 161.988 162.499 1.00 26.94  ? 820  VAL A CB  1 
ATOM   5018 C  CG1 . VAL A 1 830 ? 150.054 162.488 163.088 1.00 26.94  ? 820  VAL A CG1 1 
ATOM   5019 C  CG2 . VAL A 1 830 ? 152.231 163.166 162.108 1.00 26.94  ? 820  VAL A CG2 1 
ATOM   5020 N  N   . ALA A 1 831 ? 150.963 158.925 163.404 1.00 28.80  ? 821  ALA A N   1 
ATOM   5021 C  CA  . ALA A 1 831 ? 150.129 157.857 163.941 1.00 28.80  ? 821  ALA A CA  1 
ATOM   5022 C  C   . ALA A 1 831 ? 150.747 157.241 165.190 1.00 28.80  ? 821  ALA A C   1 
ATOM   5023 O  O   . ALA A 1 831 ? 150.031 156.897 166.135 1.00 28.80  ? 821  ALA A O   1 
ATOM   5024 C  CB  . ALA A 1 831 ? 149.893 156.789 162.875 1.00 28.80  ? 821  ALA A CB  1 
ATOM   5025 N  N   . ALA A 1 832 ? 152.072 157.083 165.212 1.00 30.80  ? 822  ALA A N   1 
ATOM   5026 C  CA  . ALA A 1 832 ? 152.729 156.575 166.411 1.00 30.80  ? 822  ALA A CA  1 
ATOM   5027 C  C   . ALA A 1 832 ? 152.616 157.558 167.568 1.00 30.80  ? 822  ALA A C   1 
ATOM   5028 O  O   . ALA A 1 832 ? 152.416 157.150 168.717 1.00 30.80  ? 822  ALA A O   1 
ATOM   5029 C  CB  . ALA A 1 832 ? 154.195 156.264 166.117 1.00 30.80  ? 822  ALA A CB  1 
ATOM   5030 N  N   . THR A 1 833 ? 152.751 158.856 167.287 1.00 33.19  ? 823  THR A N   1 
ATOM   5031 C  CA  . THR A 1 833 ? 152.759 159.848 168.357 1.00 33.19  ? 823  THR A CA  1 
ATOM   5032 C  C   . THR A 1 833 ? 151.381 160.008 168.991 1.00 33.19  ? 823  THR A C   1 
ATOM   5033 O  O   . THR A 1 833 ? 151.253 160.023 170.220 1.00 33.19  ? 823  THR A O   1 
ATOM   5034 C  CB  . THR A 1 833 ? 153.258 161.191 167.825 1.00 33.19  ? 823  THR A CB  1 
ATOM   5035 O  OG1 . THR A 1 833 ? 154.509 161.006 167.155 1.00 33.19  ? 823  THR A OG1 1 
ATOM   5036 C  CG2 . THR A 1 833 ? 153.447 162.174 168.964 1.00 33.19  ? 823  THR A CG2 1 
ATOM   5037 N  N   . GLN A 1 834 ? 150.334 160.125 168.172 1.00 38.32  ? 824  GLN A N   1 
ATOM   5038 C  CA  . GLN A 1 834 ? 149.035 160.538 168.695 1.00 38.32  ? 824  GLN A CA  1 
ATOM   5039 C  C   . GLN A 1 834 ? 148.156 159.386 169.166 1.00 38.32  ? 824  GLN A C   1 
ATOM   5040 O  O   . GLN A 1 834 ? 147.300 159.595 170.033 1.00 38.32  ? 824  GLN A O   1 
ATOM   5041 C  CB  . GLN A 1 834 ? 148.277 161.348 167.641 1.00 38.32  ? 824  GLN A CB  1 
ATOM   5042 C  CG  . GLN A 1 834 ? 149.038 162.550 167.108 1.00 38.32  ? 824  GLN A CG  1 
ATOM   5043 C  CD  . GLN A 1 834 ? 149.522 163.480 168.203 1.00 38.32  ? 824  GLN A CD  1 
ATOM   5044 O  OE1 . GLN A 1 834 ? 148.839 163.694 169.205 1.00 38.32  ? 824  GLN A OE1 1 
ATOM   5045 N  NE2 . GLN A 1 834 ? 150.710 164.042 168.015 1.00 38.32  ? 824  GLN A NE2 1 
ATOM   5046 N  N   . ASP A 1 835 ? 148.329 158.187 168.619 1.00 44.45  ? 825  ASP A N   1 
ATOM   5047 C  CA  . ASP A 1 835 ? 147.430 157.083 168.930 1.00 44.45  ? 825  ASP A CA  1 
ATOM   5048 C  C   . ASP A 1 835 ? 147.616 156.589 170.360 1.00 44.45  ? 825  ASP A C   1 
ATOM   5049 O  O   . ASP A 1 835 ? 148.717 156.613 170.914 1.00 44.45  ? 825  ASP A O   1 
ATOM   5050 C  CB  . ASP A 1 835 ? 147.653 155.923 167.966 1.00 44.45  ? 825  ASP A CB  1 
ATOM   5051 C  CG  . ASP A 1 835 ? 147.012 156.155 166.620 1.00 44.45  ? 825  ASP A CG  1 
ATOM   5052 O  OD1 . ASP A 1 835 ? 147.001 157.316 166.161 1.00 44.45  ? 825  ASP A OD1 1 
ATOM   5053 O  OD2 . ASP A 1 835 ? 146.530 155.176 166.017 1.00 44.45  ? 825  ASP A OD2 1 
ATOM   5054 N  N   . GLN A 1 836 ? 146.509 156.146 170.960 1.00 59.29  ? 826  GLN A N   1 
ATOM   5055 C  CA  . GLN A 1 836 ? 146.586 155.437 172.232 1.00 59.29  ? 826  GLN A CA  1 
ATOM   5056 C  C   . GLN A 1 836 ? 147.293 154.100 172.050 1.00 59.29  ? 826  GLN A C   1 
ATOM   5057 O  O   . GLN A 1 836 ? 148.192 153.746 172.821 1.00 59.29  ? 826  GLN A O   1 
ATOM   5058 C  CB  . GLN A 1 836 ? 145.179 155.235 172.796 1.00 59.29  ? 826  GLN A CB  1 
ATOM   5059 C  CG  . GLN A 1 836 ? 145.112 154.983 174.293 1.00 59.29  ? 826  GLN A CG  1 
ATOM   5060 C  CD  . GLN A 1 836 ? 145.262 156.258 175.099 1.00 59.29  ? 826  GLN A CD  1 
ATOM   5061 O  OE1 . GLN A 1 836 ? 144.352 157.086 175.142 1.00 59.29  ? 826  GLN A OE1 1 
ATOM   5062 N  NE2 . GLN A 1 836 ? 146.411 156.422 175.743 1.00 59.29  ? 826  GLN A NE2 1 
ATOM   5063 N  N   . TYR A 1 837 ? 146.941 153.361 171.004 1.00 64.23  ? 827  TYR A N   1 
ATOM   5064 C  CA  . TYR A 1 837 ? 147.659 152.099 170.711 1.00 64.23  ? 827  TYR A CA  1 
ATOM   5065 C  C   . TYR A 1 837 ? 148.315 152.244 169.343 1.00 64.23  ? 827  TYR A C   1 
ATOM   5066 O  O   . TYR A 1 837 ? 147.602 152.627 168.416 1.00 64.23  ? 827  TYR A O   1 
ATOM   5067 C  CB  . TYR A 1 837 ? 146.674 150.948 170.542 1.00 64.23  ? 827  TYR A CB  1 
ATOM   5068 C  CG  . TYR A 1 837 ? 145.742 150.663 171.689 1.00 64.23  ? 827  TYR A CG  1 
ATOM   5069 C  CD1 . TYR A 1 837 ? 146.222 150.327 172.942 1.00 64.23  ? 827  TYR A CD1 1 
ATOM   5070 C  CD2 . TYR A 1 837 ? 144.372 150.671 171.500 1.00 64.23  ? 827  TYR A CD2 1 
ATOM   5071 C  CE1 . TYR A 1 837 ? 145.362 150.043 173.989 1.00 64.23  ? 827  TYR A CE1 1 
ATOM   5072 C  CE2 . TYR A 1 837 ? 143.497 150.389 172.534 1.00 64.23  ? 827  TYR A CE2 1 
ATOM   5073 C  CZ  . TYR A 1 837 ? 143.995 150.075 173.783 1.00 64.23  ? 827  TYR A CZ  1 
ATOM   5074 O  OH  . TYR A 1 837 ? 143.135 149.794 174.803 1.00 64.23  ? 827  TYR A OH  1 
ATOM   5075 N  N   . ALA A 1 838 ? 149.594 151.903 169.203 1.00 45.76  ? 828  ALA A N   1 
ATOM   5076 C  CA  . ALA A 1 838 ? 150.311 152.117 167.926 1.00 45.76  ? 828  ALA A CA  1 
ATOM   5077 C  C   . ALA A 1 838 ? 150.063 150.979 166.953 1.00 45.76  ? 828  ALA A C   1 
ATOM   5078 O  O   . ALA A 1 838 ? 151.040 150.334 166.554 1.00 45.76  ? 828  ALA A O   1 
ATOM   5079 C  CB  . ALA A 1 838 ? 151.774 152.212 168.181 1.00 45.76  ? 828  ALA A CB  1 
ATOM   5080 N  N   . ASP A 1 839 ? 148.807 150.756 166.586 1.00 43.75  ? 829  ASP A N   1 
ATOM   5081 C  CA  . ASP A 1 839 ? 148.567 149.740 165.571 1.00 43.75  ? 829  ASP A CA  1 
ATOM   5082 C  C   . ASP A 1 839 ? 148.674 150.356 164.181 1.00 43.75  ? 829  ASP A C   1 
ATOM   5083 O  O   . ASP A 1 839 ? 149.242 149.748 163.268 1.00 43.75  ? 829  ASP A O   1 
ATOM   5084 C  CB  . ASP A 1 839 ? 147.188 149.108 165.799 1.00 43.75  ? 829  ASP A CB  1 
ATOM   5085 C  CG  . ASP A 1 839 ? 146.755 148.156 164.683 1.00 43.75  ? 829  ASP A CG  1 
ATOM   5086 O  OD1 . ASP A 1 839 ? 145.542 147.864 164.616 1.00 43.75  ? 829  ASP A OD1 1 
ATOM   5087 O  OD2 . ASP A 1 839 ? 147.601 147.632 163.931 1.00 43.75  ? 829  ASP A OD2 1 
ATOM   5088 N  N   . ALA A 1 840 ? 148.166 151.582 164.022 1.00 34.86  ? 830  ALA A N   1 
ATOM   5089 C  CA  . ALA A 1 840 ? 148.148 152.233 162.717 1.00 34.86  ? 830  ALA A CA  1 
ATOM   5090 C  C   . ALA A 1 840 ? 149.547 152.575 162.225 1.00 34.86  ? 830  ALA A C   1 
ATOM   5091 O  O   . ALA A 1 840 ? 149.792 152.542 161.016 1.00 34.86  ? 830  ALA A O   1 
ATOM   5092 C  CB  . ALA A 1 840 ? 147.290 153.496 162.775 1.00 34.86  ? 830  ALA A CB  1 
ATOM   5093 N  N   . SER A 1 841 ? 150.473 152.894 163.132 1.00 29.60  ? 831  SER A N   1 
ATOM   5094 C  CA  . SER A 1 841 ? 151.820 153.281 162.718 1.00 29.60  ? 831  SER A CA  1 
ATOM   5095 C  C   . SER A 1 841 ? 152.547 152.130 162.032 1.00 29.60  ? 831  SER A C   1 
ATOM   5096 O  O   . SER A 1 841 ? 153.125 152.302 160.953 1.00 29.60  ? 831  SER A O   1 
ATOM   5097 C  CB  . SER A 1 841 ? 152.615 153.770 163.925 1.00 29.60  ? 831  SER A CB  1 
ATOM   5098 O  OG  . SER A 1 841 ? 153.997 153.828 163.625 1.00 29.60  ? 831  SER A OG  1 
ATOM   5099 N  N   . ILE A 1 842 ? 152.535 150.948 162.648 1.00 28.98  ? 832  ILE A N   1 
ATOM   5100 C  CA  . ILE A 1 842 ? 153.154 149.779 162.031 1.00 28.98  ? 832  ILE A CA  1 
ATOM   5101 C  C   . ILE A 1 842 ? 152.307 149.279 160.864 1.00 28.98  ? 832  ILE A C   1 
ATOM   5102 O  O   . ILE A 1 842 ? 152.843 148.798 159.851 1.00 28.98  ? 832  ILE A O   1 
ATOM   5103 C  CB  . ILE A 1 842 ? 153.380 148.699 163.107 1.00 28.98  ? 832  ILE A CB  1 
ATOM   5104 C  CG1 . ILE A 1 842 ? 154.607 149.049 163.949 1.00 28.98  ? 832  ILE A CG1 1 
ATOM   5105 C  CG2 . ILE A 1 842 ? 153.544 147.315 162.501 1.00 28.98  ? 832  ILE A CG2 1 
ATOM   5106 C  CD1 . ILE A 1 842 ? 154.710 148.259 165.230 1.00 28.98  ? 832  ILE A CD1 1 
ATOM   5107 N  N   . GLY A 1 843 ? 150.982 149.403 160.976 1.00 23.62  ? 833  GLY A N   1 
ATOM   5108 C  CA  . GLY A 1 843 ? 150.107 148.950 159.908 1.00 23.62  ? 833  GLY A CA  1 
ATOM   5109 C  C   . GLY A 1 843 ? 150.295 149.726 158.620 1.00 23.62  ? 833  GLY A C   1 
ATOM   5110 O  O   . GLY A 1 843 ? 150.176 149.166 157.532 1.00 23.62  ? 833  GLY A O   1 
ATOM   5111 N  N   . ASN A 1 844 ? 150.589 151.023 158.725 1.00 22.56  ? 834  ASN A N   1 
ATOM   5112 C  CA  . ASN A 1 844 ? 150.863 151.817 157.533 1.00 22.56  ? 834  ASN A CA  1 
ATOM   5113 C  C   . ASN A 1 844 ? 152.121 151.331 156.827 1.00 22.56  ? 834  ASN A C   1 
ATOM   5114 O  O   . ASN A 1 844 ? 152.139 151.204 155.597 1.00 22.56  ? 834  ASN A O   1 
ATOM   5115 C  CB  . ASN A 1 844 ? 150.988 153.293 157.903 1.00 22.56  ? 834  ASN A CB  1 
ATOM   5116 C  CG  . ASN A 1 844 ? 151.532 154.134 156.768 1.00 22.56  ? 834  ASN A CG  1 
ATOM   5117 O  OD1 . ASN A 1 844 ? 152.743 154.292 156.621 1.00 22.56  ? 834  ASN A OD1 1 
ATOM   5118 N  ND2 . ASN A 1 844 ? 150.636 154.676 155.954 1.00 22.56  ? 834  ASN A ND2 1 
ATOM   5119 N  N   . VAL A 1 845 ? 153.175 151.037 157.593 1.00 20.98  ? 835  VAL A N   1 
ATOM   5120 C  CA  . VAL A 1 845 ? 154.414 150.519 157.015 1.00 20.98  ? 835  VAL A CA  1 
ATOM   5121 C  C   . VAL A 1 845 ? 154.160 149.192 156.315 1.00 20.98  ? 835  VAL A C   1 
ATOM   5122 O  O   . VAL A 1 845 ? 154.581 148.979 155.171 1.00 20.98  ? 835  VAL A O   1 
ATOM   5123 C  CB  . VAL A 1 845 ? 155.488 150.373 158.106 1.00 20.98  ? 835  VAL A CB  1 
ATOM   5124 C  CG1 . VAL A 1 845 ? 156.676 149.603 157.579 1.00 20.98  ? 835  VAL A CG1 1 
ATOM   5125 C  CG2 . VAL A 1 845 ? 155.912 151.731 158.605 1.00 20.98  ? 835  VAL A CG2 1 
ATOM   5126 N  N   . THR A 1 846 ? 153.446 148.289 156.987 1.00 24.40  ? 836  THR A N   1 
ATOM   5127 C  CA  . THR A 1 846 ? 153.221 146.963 156.420 1.00 24.40  ? 836  THR A CA  1 
ATOM   5128 C  C   . THR A 1 846 ? 152.315 147.024 155.191 1.00 24.40  ? 836  THR A C   1 
ATOM   5129 O  O   . THR A 1 846 ? 152.582 146.360 154.177 1.00 24.40  ? 836  THR A O   1 
ATOM   5130 C  CB  . THR A 1 846 ? 152.634 146.045 157.487 1.00 24.40  ? 836  THR A CB  1 
ATOM   5131 O  OG1 . THR A 1 846 ? 153.601 145.846 158.524 1.00 24.40  ? 836  THR A OG1 1 
ATOM   5132 C  CG2 . THR A 1 846 ? 152.297 144.714 156.889 1.00 24.40  ? 836  THR A CG2 1 
ATOM   5133 N  N   . GLY A 1 847 ? 151.250 147.826 155.257 1.00 22.08  ? 837  GLY A N   1 
ATOM   5134 C  CA  . GLY A 1 847 ? 150.372 147.978 154.112 1.00 22.08  ? 837  GLY A CA  1 
ATOM   5135 C  C   . GLY A 1 847 ? 151.066 148.612 152.924 1.00 22.08  ? 837  GLY A C   1 
ATOM   5136 O  O   . GLY A 1 847 ? 150.850 148.202 151.783 1.00 22.08  ? 837  GLY A O   1 
ATOM   5137 N  N   . SER A 1 848 ? 151.916 149.613 153.175 1.00 20.31  ? 838  SER A N   1 
ATOM   5138 C  CA  . SER A 1 848 ? 152.698 150.199 152.093 1.00 20.31  ? 838  SER A CA  1 
ATOM   5139 C  C   . SER A 1 848 ? 153.650 149.179 151.489 1.00 20.31  ? 838  SER A C   1 
ATOM   5140 O  O   . SER A 1 848 ? 153.812 149.124 150.266 1.00 20.31  ? 838  SER A O   1 
ATOM   5141 C  CB  . SER A 1 848 ? 153.473 151.415 152.597 1.00 20.31  ? 838  SER A CB  1 
ATOM   5142 O  OG  . SER A 1 848 ? 152.594 152.452 152.987 1.00 20.31  ? 838  SER A OG  1 
ATOM   5143 N  N   . ASN A 1 849 ? 154.278 148.351 152.326 1.00 21.03  ? 839  ASN A N   1 
ATOM   5144 C  CA  . ASN A 1 849 ? 155.243 147.388 151.807 1.00 21.03  ? 839  ASN A CA  1 
ATOM   5145 C  C   . ASN A 1 849 ? 154.571 146.291 150.992 1.00 21.03  ? 839  ASN A C   1 
ATOM   5146 O  O   . ASN A 1 849 ? 155.175 145.764 150.053 1.00 21.03  ? 839  ASN A O   1 
ATOM   5147 C  CB  . ASN A 1 849 ? 156.050 146.787 152.952 1.00 21.03  ? 839  ASN A CB  1 
ATOM   5148 C  CG  . ASN A 1 849 ? 157.263 147.615 153.288 1.00 21.03  ? 839  ASN A CG  1 
ATOM   5149 O  OD1 . ASN A 1 849 ? 157.690 148.446 152.493 1.00 21.03  ? 839  ASN A OD1 1 
ATOM   5150 N  ND2 . ASN A 1 849 ? 157.826 147.396 154.465 1.00 21.03  ? 839  ASN A ND2 1 
ATOM   5151 N  N   . ALA A 1 850 ? 153.337 145.924 151.335 1.00 20.50  ? 840  ALA A N   1 
ATOM   5152 C  CA  . ALA A 1 850 ? 152.609 144.979 150.491 1.00 20.50  ? 840  ALA A CA  1 
ATOM   5153 C  C   . ALA A 1 850 ? 152.099 145.640 149.213 1.00 20.50  ? 840  ALA A C   1 
ATOM   5154 O  O   . ALA A 1 850 ? 152.193 145.056 148.121 1.00 20.50  ? 840  ALA A O   1 
ATOM   5155 C  CB  . ALA A 1 850 ? 151.446 144.364 151.268 1.00 20.50  ? 840  ALA A CB  1 
ATOM   5156 N  N   . VAL A 1 851 ? 151.565 146.858 149.339 1.00 18.88  ? 841  VAL A N   1 
ATOM   5157 C  CA  . VAL A 1 851 ? 150.930 147.537 148.217 1.00 18.88  ? 841  VAL A CA  1 
ATOM   5158 C  C   . VAL A 1 851 ? 151.957 147.905 147.156 1.00 18.88  ? 841  VAL A C   1 
ATOM   5159 O  O   . VAL A 1 851 ? 151.665 147.836 145.959 1.00 18.88  ? 841  VAL A O   1 
ATOM   5160 C  CB  . VAL A 1 851 ? 150.146 148.761 148.731 1.00 18.88  ? 841  VAL A CB  1 
ATOM   5161 C  CG1 . VAL A 1 851 ? 150.049 149.854 147.684 1.00 18.88  ? 841  VAL A CG1 1 
ATOM   5162 C  CG2 . VAL A 1 851 ? 148.757 148.338 149.174 1.00 18.88  ? 841  VAL A CG2 1 
ATOM   5163 N  N   . ASN A 1 852 ? 153.177 148.271 147.572 1.00 17.90  ? 842  ASN A N   1 
ATOM   5164 C  CA  . ASN A 1 852 ? 154.256 148.577 146.633 1.00 17.90  ? 842  ASN A CA  1 
ATOM   5165 C  C   . ASN A 1 852 ? 154.426 147.474 145.599 1.00 17.90  ? 842  ASN A C   1 
ATOM   5166 O  O   . ASN A 1 852 ? 154.263 147.706 144.398 1.00 17.90  ? 842  ASN A O   1 
ATOM   5167 C  CB  . ASN A 1 852 ? 155.569 148.799 147.385 1.00 17.90  ? 842  ASN A CB  1 
ATOM   5168 C  CG  . ASN A 1 852 ? 155.636 150.148 148.048 1.00 17.90  ? 842  ASN A CG  1 
ATOM   5169 O  OD1 . ASN A 1 852 ? 154.744 150.975 147.884 1.00 17.90  ? 842  ASN A OD1 1 
ATOM   5170 N  ND2 . ASN A 1 852 ? 156.703 150.386 148.797 1.00 17.90  ? 842  ASN A ND2 1 
ATOM   5171 N  N   . VAL A 1 853 ? 154.698 146.250 146.057 1.00 20.63  ? 843  VAL A N   1 
ATOM   5172 C  CA  . VAL A 1 853 ? 154.822 145.128 145.132 1.00 20.63  ? 843  VAL A CA  1 
ATOM   5173 C  C   . VAL A 1 853 ? 153.513 144.910 144.390 1.00 20.63  ? 843  VAL A C   1 
ATOM   5174 O  O   . VAL A 1 853 ? 153.457 145.067 143.163 1.00 20.63  ? 843  VAL A O   1 
ATOM   5175 C  CB  . VAL A 1 853 ? 155.270 143.855 145.867 1.00 20.63  ? 843  VAL A CB  1 
ATOM   5176 C  CG1 . VAL A 1 853 ? 155.030 142.630 145.003 1.00 20.63  ? 843  VAL A CG1 1 
ATOM   5177 C  CG2 . VAL A 1 853 ? 156.721 143.951 146.174 1.00 20.63  ? 843  VAL A CG2 1 
ATOM   5178 N  N   . PHE A 1 854 ? 152.428 144.650 145.138 1.00 26.45  ? 844  PHE A N   1 
ATOM   5179 C  CA  . PHE A 1 854 ? 151.213 144.108 144.533 1.00 26.45  ? 844  PHE A CA  1 
ATOM   5180 C  C   . PHE A 1 854 ? 150.584 145.057 143.526 1.00 26.45  ? 844  PHE A C   1 
ATOM   5181 O  O   . PHE A 1 854 ? 149.911 144.605 142.594 1.00 26.45  ? 844  PHE A O   1 
ATOM   5182 C  CB  . PHE A 1 854 ? 150.201 143.745 145.615 1.00 26.45  ? 844  PHE A CB  1 
ATOM   5183 C  CG  . PHE A 1 854 ? 150.543 142.494 146.361 1.00 26.45  ? 844  PHE A CG  1 
ATOM   5184 C  CD1 . PHE A 1 854 ? 151.171 141.444 145.717 1.00 26.45  ? 844  PHE A CD1 1 
ATOM   5185 C  CD2 . PHE A 1 854 ? 150.232 142.363 147.700 1.00 26.45  ? 844  PHE A CD2 1 
ATOM   5186 C  CE1 . PHE A 1 854 ? 151.488 140.291 146.396 1.00 26.45  ? 844  PHE A CE1 1 
ATOM   5187 C  CE2 . PHE A 1 854 ? 150.546 141.210 148.382 1.00 26.45  ? 844  PHE A CE2 1 
ATOM   5188 C  CZ  . PHE A 1 854 ? 151.169 140.171 147.728 1.00 26.45  ? 844  PHE A CZ  1 
ATOM   5189 N  N   . LEU A 1 855 ? 150.784 146.365 143.679 1.00 23.43  ? 845  LEU A N   1 
ATOM   5190 C  CA  . LEU A 1 855 ? 150.354 147.289 142.641 1.00 23.43  ? 845  LEU A CA  1 
ATOM   5191 C  C   . LEU A 1 855 ? 151.458 147.554 141.627 1.00 23.43  ? 845  LEU A C   1 
ATOM   5192 O  O   . LEU A 1 855 ? 151.285 147.238 140.453 1.00 23.43  ? 845  LEU A O   1 
ATOM   5193 C  CB  . LEU A 1 855 ? 149.863 148.604 143.247 1.00 23.43  ? 845  LEU A CB  1 
ATOM   5194 C  CG  . LEU A 1 855 ? 148.482 148.513 143.879 1.00 23.43  ? 845  LEU A CG  1 
ATOM   5195 C  CD1 . LEU A 1 855 ? 148.058 149.886 144.313 1.00 23.43  ? 845  LEU A CD1 1 
ATOM   5196 C  CD2 . LEU A 1 855 ? 147.490 147.926 142.894 1.00 23.43  ? 845  LEU A CD2 1 
ATOM   5197 N  N   . GLY A 1 856 ? 152.588 148.125 142.052 1.00 22.91  ? 846  GLY A N   1 
ATOM   5198 C  CA  . GLY A 1 856 ? 153.604 148.544 141.106 1.00 22.91  ? 846  GLY A CA  1 
ATOM   5199 C  C   . GLY A 1 856 ? 154.149 147.435 140.235 1.00 22.91  ? 846  GLY A C   1 
ATOM   5200 O  O   . GLY A 1 856 ? 153.979 147.466 139.006 1.00 22.91  ? 846  GLY A O   1 
ATOM   5201 N  N   . ILE A 1 857 ? 154.775 146.435 140.863 1.00 22.66  ? 847  ILE A N   1 
ATOM   5202 C  CA  . ILE A 1 857 ? 155.369 145.356 140.087 1.00 22.66  ? 847  ILE A CA  1 
ATOM   5203 C  C   . ILE A 1 857 ? 154.277 144.562 139.391 1.00 22.66  ? 847  ILE A C   1 
ATOM   5204 O  O   . ILE A 1 857 ? 154.428 144.163 138.231 1.00 22.66  ? 847  ILE A O   1 
ATOM   5205 C  CB  . ILE A 1 857 ? 156.256 144.478 140.988 1.00 22.66  ? 847  ILE A CB  1 
ATOM   5206 C  CG1 . ILE A 1 857 ? 157.527 145.240 141.359 1.00 22.66  ? 847  ILE A CG1 1 
ATOM   5207 C  CG2 . ILE A 1 857 ? 156.611 143.174 140.310 1.00 22.66  ? 847  ILE A CG2 1 
ATOM   5208 C  CD1 . ILE A 1 857 ? 158.379 144.544 142.380 1.00 22.66  ? 847  ILE A CD1 1 
ATOM   5209 N  N   . GLY A 1 858 ? 153.134 144.402 140.055 1.00 26.35  ? 848  GLY A N   1 
ATOM   5210 C  CA  . GLY A 1 858 ? 151.948 143.810 139.470 1.00 26.35  ? 848  GLY A CA  1 
ATOM   5211 C  C   . GLY A 1 858 ? 151.547 144.384 138.125 1.00 26.35  ? 848  GLY A C   1 
ATOM   5212 O  O   . GLY A 1 858 ? 151.674 143.686 137.116 1.00 26.35  ? 848  GLY A O   1 
ATOM   5213 N  N   . VAL A 1 859 ? 151.109 145.648 138.077 1.00 25.73  ? 849  VAL A N   1 
ATOM   5214 C  CA  . VAL A 1 859 ? 150.589 146.179 136.818 1.00 25.73  ? 849  VAL A CA  1 
ATOM   5215 C  C   . VAL A 1 859 ? 151.723 146.359 135.818 1.00 25.73  ? 849  VAL A C   1 
ATOM   5216 O  O   . VAL A 1 859 ? 151.554 146.081 134.627 1.00 25.73  ? 849  VAL A O   1 
ATOM   5217 C  CB  . VAL A 1 859 ? 149.796 147.493 137.006 1.00 25.73  ? 849  VAL A CB  1 
ATOM   5218 C  CG1 . VAL A 1 859 ? 150.518 148.497 137.853 1.00 25.73  ? 849  VAL A CG1 1 
ATOM   5219 C  CG2 . VAL A 1 859 ? 149.402 148.109 135.672 1.00 25.73  ? 849  VAL A CG2 1 
ATOM   5220 N  N   . ALA A 1 860 ? 152.904 146.798 136.277 1.00 26.20  ? 850  ALA A N   1 
ATOM   5221 C  CA  . ALA A 1 860 ? 153.999 147.049 135.344 1.00 26.20  ? 850  ALA A CA  1 
ATOM   5222 C  C   . ALA A 1 860 ? 154.441 145.769 134.641 1.00 26.20  ? 850  ALA A C   1 
ATOM   5223 O  O   . ALA A 1 860 ? 154.470 145.702 133.401 1.00 26.20  ? 850  ALA A O   1 
ATOM   5224 C  CB  . ALA A 1 860 ? 155.168 147.690 136.089 1.00 26.20  ? 850  ALA A CB  1 
ATOM   5225 N  N   . TRP A 1 861 ? 154.747 144.723 135.413 1.00 28.59  ? 851  TRP A N   1 
ATOM   5226 C  CA  . TRP A 1 861 ? 155.190 143.478 134.810 1.00 28.59  ? 851  TRP A CA  1 
ATOM   5227 C  C   . TRP A 1 861 ? 154.055 142.765 134.091 1.00 28.59  ? 851  TRP A C   1 
ATOM   5228 O  O   . TRP A 1 861 ? 154.304 142.085 133.093 1.00 28.59  ? 851  TRP A O   1 
ATOM   5229 C  CB  . TRP A 1 861 ? 155.817 142.578 135.871 1.00 28.59  ? 851  TRP A CB  1 
ATOM   5230 C  CG  . TRP A 1 861 ? 157.215 142.977 136.203 1.00 28.59  ? 851  TRP A CG  1 
ATOM   5231 C  CD1 . TRP A 1 861 ? 157.871 144.089 135.769 1.00 28.59  ? 851  TRP A CD1 1 
ATOM   5232 C  CD2 . TRP A 1 861 ? 158.137 142.266 137.034 1.00 28.59  ? 851  TRP A CD2 1 
ATOM   5233 N  NE1 . TRP A 1 861 ? 159.144 144.118 136.281 1.00 28.59  ? 851  TRP A NE1 1 
ATOM   5234 C  CE2 . TRP A 1 861 ? 159.333 143.009 137.061 1.00 28.59  ? 851  TRP A CE2 1 
ATOM   5235 C  CE3 . TRP A 1 861 ? 158.069 141.074 137.759 1.00 28.59  ? 851  TRP A CE3 1 
ATOM   5236 C  CZ2 . TRP A 1 861 ? 160.449 142.598 137.782 1.00 28.59  ? 851  TRP A CZ2 1 
ATOM   5237 C  CZ3 . TRP A 1 861 ? 159.177 140.670 138.475 1.00 28.59  ? 851  TRP A CZ3 1 
ATOM   5238 C  CH2 . TRP A 1 861 ? 160.351 141.430 138.483 1.00 28.59  ? 851  TRP A CH2 1 
ATOM   5239 N  N   . SER A 1 862 ? 152.806 142.918 134.548 1.00 32.42  ? 852  SER A N   1 
ATOM   5240 C  CA  . SER A 1 862 ? 151.697 142.310 133.823 1.00 32.42  ? 852  SER A CA  1 
ATOM   5241 C  C   . SER A 1 862 ? 151.503 142.961 132.461 1.00 32.42  ? 852  SER A C   1 
ATOM   5242 O  O   . SER A 1 862 ? 151.283 142.263 131.469 1.00 32.42  ? 852  SER A O   1 
ATOM   5243 C  CB  . SER A 1 862 ? 150.412 142.397 134.641 1.00 32.42  ? 852  SER A CB  1 
ATOM   5244 O  OG  . SER A 1 862 ? 149.948 143.732 134.708 1.00 32.42  ? 852  SER A OG  1 
ATOM   5245 N  N   . ILE A 1 863 ? 151.585 144.293 132.390 1.00 35.14  ? 853  ILE A N   1 
ATOM   5246 C  CA  . ILE A 1 863 ? 151.455 144.988 131.111 1.00 35.14  ? 853  ILE A CA  1 
ATOM   5247 C  C   . ILE A 1 863 ? 152.586 144.585 130.175 1.00 35.14  ? 853  ILE A C   1 
ATOM   5248 O  O   . ILE A 1 863 ? 152.364 144.295 128.989 1.00 35.14  ? 853  ILE A O   1 
ATOM   5249 C  CB  . ILE A 1 863 ? 151.416 146.512 131.329 1.00 35.14  ? 853  ILE A CB  1 
ATOM   5250 C  CG1 . ILE A 1 863 ? 150.051 146.949 131.857 1.00 35.14  ? 853  ILE A CG1 1 
ATOM   5251 C  CG2 . ILE A 1 863 ? 151.735 147.254 130.049 1.00 35.14  ? 853  ILE A CG2 1 
ATOM   5252 C  CD1 . ILE A 1 863 ? 149.944 148.442 132.069 1.00 35.14  ? 853  ILE A CD1 1 
ATOM   5253 N  N   . ALA A 1 864 ? 153.816 144.540 130.701 1.00 36.25  ? 854  ALA A N   1 
ATOM   5254 C  CA  . ALA A 1 864 ? 154.949 144.122 129.882 1.00 36.25  ? 854  ALA A CA  1 
ATOM   5255 C  C   . ALA A 1 864 ? 154.776 142.692 129.381 1.00 36.25  ? 854  ALA A C   1 
ATOM   5256 O  O   . ALA A 1 864 ? 155.029 142.404 128.205 1.00 36.25  ? 854  ALA A O   1 
ATOM   5257 C  CB  . ALA A 1 864 ? 156.246 144.260 130.675 1.00 36.25  ? 854  ALA A CB  1 
ATOM   5258 N  N   . ALA A 1 865 ? 154.315 141.790 130.254 1.00 42.98  ? 855  ALA A N   1 
ATOM   5259 C  CA  . ALA A 1 865 ? 154.143 140.392 129.878 1.00 42.98  ? 855  ALA A CA  1 
ATOM   5260 C  C   . ALA A 1 865 ? 153.040 140.217 128.843 1.00 42.98  ? 855  ALA A C   1 
ATOM   5261 O  O   . ALA A 1 865 ? 153.202 139.446 127.894 1.00 42.98  ? 855  ALA A O   1 
ATOM   5262 C  CB  . ALA A 1 865 ? 153.852 139.548 131.118 1.00 42.98  ? 855  ALA A CB  1 
ATOM   5263 N  N   . ILE A 1 866 ? 151.913 140.918 129.005 1.00 44.25  ? 856  ILE A N   1 
ATOM   5264 C  CA  . ILE A 1 866 ? 150.833 140.823 128.022 1.00 44.25  ? 856  ILE A CA  1 
ATOM   5265 C  C   . ILE A 1 866 ? 151.290 141.348 126.669 1.00 44.25  ? 856  ILE A C   1 
ATOM   5266 O  O   . ILE A 1 866 ? 151.070 140.704 125.636 1.00 44.25  ? 856  ILE A O   1 
ATOM   5267 C  CB  . ILE A 1 866 ? 149.569 141.551 128.516 1.00 44.25  ? 856  ILE A CB  1 
ATOM   5268 C  CG1 . ILE A 1 866 ? 149.047 140.912 129.807 1.00 44.25  ? 856  ILE A CG1 1 
ATOM   5269 C  CG2 . ILE A 1 866 ? 148.506 141.575 127.423 1.00 44.25  ? 856  ILE A CG2 1 
ATOM   5270 C  CD1 . ILE A 1 866 ? 147.567 141.127 130.070 1.00 44.25  ? 856  ILE A CD1 1 
ATOM   5271 N  N   . TYR A 1 867 ? 151.951 142.512 126.653 1.00 50.03  ? 857  TYR A N   1 
ATOM   5272 C  CA  . TYR A 1 867 ? 152.408 143.077 125.385 1.00 50.03  ? 857  TYR A CA  1 
ATOM   5273 C  C   . TYR A 1 867 ? 153.403 142.151 124.697 1.00 50.03  ? 857  TYR A C   1 
ATOM   5274 O  O   . TYR A 1 867 ? 153.290 141.881 123.495 1.00 50.03  ? 857  TYR A O   1 
ATOM   5275 C  CB  . TYR A 1 867 ? 153.011 144.467 125.617 1.00 50.03  ? 857  TYR A CB  1 
ATOM   5276 C  CG  . TYR A 1 867 ? 153.919 144.982 124.511 1.00 50.03  ? 857  TYR A CG  1 
ATOM   5277 C  CD1 . TYR A 1 867 ? 155.291 144.731 124.523 1.00 50.03  ? 857  TYR A CD1 1 
ATOM   5278 C  CD2 . TYR A 1 867 ? 153.402 145.713 123.451 1.00 50.03  ? 857  TYR A CD2 1 
ATOM   5279 C  CE1 . TYR A 1 867 ? 156.111 145.197 123.516 1.00 50.03  ? 857  TYR A CE1 1 
ATOM   5280 C  CE2 . TYR A 1 867 ? 154.219 146.183 122.440 1.00 50.03  ? 857  TYR A CE2 1 
ATOM   5281 C  CZ  . TYR A 1 867 ? 155.571 145.922 122.479 1.00 50.03  ? 857  TYR A CZ  1 
ATOM   5282 O  OH  . TYR A 1 867 ? 156.388 146.386 121.476 1.00 50.03  ? 857  TYR A OH  1 
ATOM   5283 N  N   . HIS A 1 868 ? 154.376 141.636 125.452 1.00 52.70  ? 858  HIS A N   1 
ATOM   5284 C  CA  . HIS A 1 868 ? 155.397 140.785 124.854 1.00 52.70  ? 858  HIS A CA  1 
ATOM   5285 C  C   . HIS A 1 868 ? 154.821 139.449 124.397 1.00 52.70  ? 858  HIS A C   1 
ATOM   5286 O  O   . HIS A 1 868 ? 155.139 138.979 123.298 1.00 52.70  ? 858  HIS A O   1 
ATOM   5287 C  CB  . HIS A 1 868 ? 156.540 140.582 125.843 1.00 52.70  ? 858  HIS A CB  1 
ATOM   5288 C  CG  . HIS A 1 868 ? 157.626 141.604 125.724 1.00 52.70  ? 858  HIS A CG  1 
ATOM   5289 N  ND1 . HIS A 1 868 ? 158.802 141.366 125.047 1.00 52.70  ? 858  HIS A ND1 1 
ATOM   5290 C  CD2 . HIS A 1 868 ? 157.711 142.872 126.190 1.00 52.70  ? 858  HIS A CD2 1 
ATOM   5291 C  CE1 . HIS A 1 868 ? 159.567 142.441 125.106 1.00 52.70  ? 858  HIS A CE1 1 
ATOM   5292 N  NE2 . HIS A 1 868 ? 158.928 143.369 125.793 1.00 52.70  ? 858  HIS A NE2 1 
ATOM   5293 N  N   . ALA A 1 869 ? 153.965 138.827 125.214 1.00 56.21  ? 859  ALA A N   1 
ATOM   5294 C  CA  . ALA A 1 869 ? 153.390 137.535 124.855 1.00 56.21  ? 859  ALA A CA  1 
ATOM   5295 C  C   . ALA A 1 869 ? 152.454 137.651 123.659 1.00 56.21  ? 859  ALA A C   1 
ATOM   5296 O  O   . ALA A 1 869 ? 152.426 136.760 122.802 1.00 56.21  ? 859  ALA A O   1 
ATOM   5297 C  CB  . ALA A 1 869 ? 152.658 136.937 126.055 1.00 56.21  ? 859  ALA A CB  1 
ATOM   5298 N  N   . ALA A 1 870 ? 151.671 138.731 123.586 1.00 57.94  ? 860  ALA A N   1 
ATOM   5299 C  CA  . ALA A 1 870 ? 150.843 138.957 122.408 1.00 57.94  ? 860  ALA A CA  1 
ATOM   5300 C  C   . ALA A 1 870 ? 151.701 139.213 121.176 1.00 57.94  ? 860  ALA A C   1 
ATOM   5301 O  O   . ALA A 1 870 ? 151.379 138.739 120.081 1.00 57.94  ? 860  ALA A O   1 
ATOM   5302 C  CB  . ALA A 1 870 ? 149.886 140.122 122.651 1.00 57.94  ? 860  ALA A CB  1 
ATOM   5303 N  N   . ASN A 1 871 ? 152.798 139.959 121.334 1.00 64.09  ? 861  ASN A N   1 
ATOM   5304 C  CA  . ASN A 1 871 ? 153.685 140.220 120.208 1.00 64.09  ? 861  ASN A CA  1 
ATOM   5305 C  C   . ASN A 1 871 ? 154.413 138.968 119.734 1.00 64.09  ? 861  ASN A C   1 
ATOM   5306 O  O   . ASN A 1 871 ? 154.838 138.916 118.575 1.00 64.09  ? 861  ASN A O   1 
ATOM   5307 C  CB  . ASN A 1 871 ? 154.697 141.304 120.580 1.00 64.09  ? 861  ASN A CB  1 
ATOM   5308 C  CG  . ASN A 1 871 ? 155.455 141.828 119.380 1.00 64.09  ? 861  ASN A CG  1 
ATOM   5309 O  OD1 . ASN A 1 871 ? 154.929 141.862 118.268 1.00 64.09  ? 861  ASN A OD1 1 
ATOM   5310 N  ND2 . ASN A 1 871 ? 156.698 142.241 119.598 1.00 64.09  ? 861  ASN A ND2 1 
ATOM   5311 N  N   . GLY A 1 872 ? 154.557 137.961 120.589 1.00 65.89  ? 862  GLY A N   1 
ATOM   5312 C  CA  . GLY A 1 872 ? 155.222 136.730 120.221 1.00 65.89  ? 862  GLY A CA  1 
ATOM   5313 C  C   . GLY A 1 872 ? 156.648 136.579 120.704 1.00 65.89  ? 862  GLY A C   1 
ATOM   5314 O  O   . GLY A 1 872 ? 157.325 135.633 120.284 1.00 65.89  ? 862  GLY A O   1 
ATOM   5315 N  N   . GLU A 1 873 ? 157.125 137.471 121.568 1.00 63.38  ? 863  GLU A N   1 
ATOM   5316 C  CA  . GLU A 1 873 ? 158.466 137.393 122.132 1.00 63.38  ? 863  GLU A CA  1 
ATOM   5317 C  C   . GLU A 1 873 ? 158.354 137.287 123.644 1.00 63.38  ? 863  GLU A C   1 
ATOM   5318 O  O   . GLU A 1 873 ? 157.585 138.025 124.264 1.00 63.38  ? 863  GLU A O   1 
ATOM   5319 C  CB  . GLU A 1 873 ? 159.299 138.616 121.742 1.00 63.38  ? 863  GLU A CB  1 
ATOM   5320 C  CG  . GLU A 1 873 ? 160.216 138.388 120.553 1.00 63.38  ? 863  GLU A CG  1 
ATOM   5321 C  CD  . GLU A 1 873 ? 161.550 139.094 120.702 1.00 63.38  ? 863  GLU A CD  1 
ATOM   5322 O  OE1 . GLU A 1 873 ? 161.710 139.867 121.670 1.00 63.38  ? 863  GLU A OE1 1 
ATOM   5323 O  OE2 . GLU A 1 873 ? 162.437 138.876 119.851 1.00 63.38  ? 863  GLU A OE2 1 
ATOM   5324 N  N   . GLN A 1 874 ? 159.112 136.369 124.237 1.00 60.63  ? 864  GLN A N   1 
ATOM   5325 C  CA  . GLN A 1 874 ? 159.004 136.143 125.671 1.00 60.63  ? 864  GLN A CA  1 
ATOM   5326 C  C   . GLN A 1 874 ? 159.685 137.267 126.445 1.00 60.63  ? 864  GLN A C   1 
ATOM   5327 O  O   . GLN A 1 874 ? 160.787 137.703 126.102 1.00 60.63  ? 864  GLN A O   1 
ATOM   5328 C  CB  . GLN A 1 874 ? 159.611 134.790 126.037 1.00 60.63  ? 864  GLN A CB  1 
ATOM   5329 C  CG  . GLN A 1 874 ? 159.204 134.279 127.407 1.00 60.63  ? 864  GLN A CG  1 
ATOM   5330 C  CD  . GLN A 1 874 ? 159.654 132.852 127.651 1.00 60.63  ? 864  GLN A CD  1 
ATOM   5331 O  OE1 . GLN A 1 874 ? 160.549 132.346 126.975 1.00 60.63  ? 864  GLN A OE1 1 
ATOM   5332 N  NE2 . GLN A 1 874 ? 159.025 132.192 128.615 1.00 60.63  ? 864  GLN A NE2 1 
ATOM   5333 N  N   . PHE A 1 875 ? 159.016 137.736 127.497 1.00 45.57  ? 865  PHE A N   1 
ATOM   5334 C  CA  . PHE A 1 875 ? 159.484 138.879 128.270 1.00 45.57  ? 865  PHE A CA  1 
ATOM   5335 C  C   . PHE A 1 875 ? 160.543 138.443 129.275 1.00 45.57  ? 865  PHE A C   1 
ATOM   5336 O  O   . PHE A 1 875 ? 160.325 137.507 130.048 1.00 45.57  ? 865  PHE A O   1 
ATOM   5337 C  CB  . PHE A 1 875 ? 158.297 139.538 128.972 1.00 45.57  ? 865  PHE A CB  1 
ATOM   5338 C  CG  . PHE A 1 875 ? 158.677 140.561 129.998 1.00 45.57  ? 865  PHE A CG  1 
ATOM   5339 C  CD1 . PHE A 1 875 ? 159.127 141.810 129.616 1.00 45.57  ? 865  PHE A CD1 1 
ATOM   5340 C  CD2 . PHE A 1 875 ? 158.525 140.293 131.344 1.00 45.57  ? 865  PHE A CD2 1 
ATOM   5341 C  CE1 . PHE A 1 875 ? 159.462 142.758 130.562 1.00 45.57  ? 865  PHE A CE1 1 
ATOM   5342 C  CE2 . PHE A 1 875 ? 158.849 141.239 132.292 1.00 45.57  ? 865  PHE A CE2 1 
ATOM   5343 C  CZ  . PHE A 1 875 ? 159.318 142.473 131.900 1.00 45.57  ? 865  PHE A CZ  1 
ATOM   5344 N  N   . LYS A 1 876 ? 161.685 139.130 129.271 1.00 48.73  ? 866  LYS A N   1 
ATOM   5345 C  CA  . LYS A 1 876 ? 162.876 138.692 129.989 1.00 48.73  ? 866  LYS A CA  1 
ATOM   5346 C  C   . LYS A 1 876 ? 163.226 139.670 131.102 1.00 48.73  ? 866  LYS A C   1 
ATOM   5347 O  O   . LYS A 1 876 ? 163.256 140.885 130.881 1.00 48.73  ? 866  LYS A O   1 
ATOM   5348 C  CB  . LYS A 1 876 ? 164.066 138.557 129.035 1.00 48.73  ? 866  LYS A CB  1 
ATOM   5349 C  CG  . LYS A 1 876 ? 163.880 137.531 127.933 1.00 48.73  ? 866  LYS A CG  1 
ATOM   5350 C  CD  . LYS A 1 876 ? 163.880 136.121 128.485 1.00 48.73  ? 866  LYS A CD  1 
ATOM   5351 C  CE  . LYS A 1 876 ? 163.592 135.106 127.394 1.00 48.73  ? 866  LYS A CE  1 
ATOM   5352 N  NZ  . LYS A 1 876 ? 164.721 135.002 126.430 1.00 48.73  ? 866  LYS A NZ  1 
ATOM   5353 N  N   . VAL A 1 877 ? 163.493 139.134 132.293 1.00 43.54  ? 867  VAL A N   1 
ATOM   5354 C  CA  . VAL A 1 877 ? 164.039 139.887 133.418 1.00 43.54  ? 867  VAL A CA  1 
ATOM   5355 C  C   . VAL A 1 877 ? 165.184 139.081 134.014 1.00 43.54  ? 867  VAL A C   1 
ATOM   5356 O  O   . VAL A 1 877 ? 165.017 137.894 134.313 1.00 43.54  ? 867  VAL A O   1 
ATOM   5357 C  CB  . VAL A 1 877 ? 162.975 140.180 134.495 1.00 43.54  ? 867  VAL A CB  1 
ATOM   5358 C  CG1 . VAL A 1 877 ? 163.620 140.769 135.733 1.00 43.54  ? 867  VAL A CG1 1 
ATOM   5359 C  CG2 . VAL A 1 877 ? 161.938 141.135 133.966 1.00 43.54  ? 867  VAL A CG2 1 
ATOM   5360 N  N   . SER A 1 878 ? 166.338 139.718 134.187 1.00 47.45  ? 868  SER A N   1 
ATOM   5361 C  CA  . SER A 1 878 ? 167.476 139.050 134.809 1.00 47.45  ? 868  SER A CA  1 
ATOM   5362 C  C   . SER A 1 878 ? 167.285 139.023 136.321 1.00 47.45  ? 868  SER A C   1 
ATOM   5363 O  O   . SER A 1 878 ? 167.218 140.088 136.944 1.00 47.45  ? 868  SER A O   1 
ATOM   5364 C  CB  . SER A 1 878 ? 168.775 139.760 134.455 1.00 47.45  ? 868  SER A CB  1 
ATOM   5365 O  OG  . SER A 1 878 ? 168.988 140.882 135.296 1.00 47.45  ? 868  SER A OG  1 
ATOM   5366 N  N   . PRO A 1 879 ? 167.197 137.849 136.945 1.00 42.98  ? 869  PRO A N   1 
ATOM   5367 C  CA  . PRO A 1 879 ? 166.893 137.771 138.380 1.00 42.98  ? 869  PRO A CA  1 
ATOM   5368 C  C   . PRO A 1 879 ? 168.096 137.843 139.309 1.00 42.98  ? 869  PRO A C   1 
ATOM   5369 O  O   . PRO A 1 879 ? 167.900 137.857 140.530 1.00 42.98  ? 869  PRO A O   1 
ATOM   5370 C  CB  . PRO A 1 879 ? 166.220 136.395 138.493 1.00 42.98  ? 869  PRO A CB  1 
ATOM   5371 C  CG  . PRO A 1 879 ? 166.864 135.586 137.421 1.00 42.98  ? 869  PRO A CG  1 
ATOM   5372 C  CD  . PRO A 1 879 ? 167.188 136.525 136.297 1.00 42.98  ? 869  PRO A CD  1 
ATOM   5373 N  N   . GLY A 1 880 ? 169.314 137.893 138.765 1.00 41.85  ? 870  GLY A N   1 
ATOM   5374 C  CA  . GLY A 1 880 ? 170.501 137.686 139.582 1.00 41.85  ? 870  GLY A CA  1 
ATOM   5375 C  C   . GLY A 1 880 ? 170.715 138.766 140.625 1.00 41.85  ? 870  GLY A C   1 
ATOM   5376 O  O   . GLY A 1 880 ? 171.046 138.476 141.777 1.00 41.85  ? 870  GLY A O   1 
ATOM   5377 N  N   . THR A 1 881 ? 170.545 140.030 140.233 1.00 42.62  ? 871  THR A N   1 
ATOM   5378 C  CA  . THR A 1 881 ? 170.773 141.122 141.175 1.00 42.62  ? 871  THR A CA  1 
ATOM   5379 C  C   . THR A 1 881 ? 169.640 141.231 142.189 1.00 42.62  ? 871  THR A C   1 
ATOM   5380 O  O   . THR A 1 881 ? 169.886 141.404 143.389 1.00 42.62  ? 871  THR A O   1 
ATOM   5381 C  CB  . THR A 1 881 ? 170.948 142.438 140.416 1.00 42.62  ? 871  THR A CB  1 
ATOM   5382 O  OG1 . THR A 1 881 ? 172.076 142.336 139.537 1.00 42.62  ? 871  THR A OG1 1 
ATOM   5383 C  CG2 . THR A 1 881 ? 171.169 143.592 141.378 1.00 42.62  ? 871  THR A CG2 1 
ATOM   5384 N  N   . LEU A 1 882 ? 168.393 141.112 141.728 1.00 35.53  ? 872  LEU A N   1 
ATOM   5385 C  CA  . LEU A 1 882 ? 167.251 141.338 142.607 1.00 35.53  ? 872  LEU A CA  1 
ATOM   5386 C  C   . LEU A 1 882 ? 167.049 140.184 143.583 1.00 35.53  ? 872  LEU A C   1 
ATOM   5387 O  O   . LEU A 1 882 ? 166.512 140.394 144.678 1.00 35.53  ? 872  LEU A O   1 
ATOM   5388 C  CB  . LEU A 1 882 ? 165.993 141.570 141.764 1.00 35.53  ? 872  LEU A CB  1 
ATOM   5389 C  CG  . LEU A 1 882 ? 164.688 142.020 142.427 1.00 35.53  ? 872  LEU A CG  1 
ATOM   5390 C  CD1 . LEU A 1 882 ? 163.934 142.913 141.469 1.00 35.53  ? 872  LEU A CD1 1 
ATOM   5391 C  CD2 . LEU A 1 882 ? 163.805 140.863 142.849 1.00 35.53  ? 872  LEU A CD2 1 
ATOM   5392 N  N   . ALA A 1 883 ? 167.445 138.964 143.200 1.00 33.07  ? 873  ALA A N   1 
ATOM   5393 C  CA  . ALA A 1 883 ? 167.231 137.805 144.062 1.00 33.07  ? 873  ALA A CA  1 
ATOM   5394 C  C   . ALA A 1 883 ? 168.002 137.931 145.370 1.00 33.07  ? 873  ALA A C   1 
ATOM   5395 O  O   . ALA A 1 883 ? 167.466 137.637 146.447 1.00 33.07  ? 873  ALA A O   1 
ATOM   5396 C  CB  . ALA A 1 883 ? 167.629 136.527 143.326 1.00 33.07  ? 873  ALA A CB  1 
ATOM   5397 N  N   . PHE A 1 884 ? 169.256 138.381 145.299 1.00 33.24  ? 874  PHE A N   1 
ATOM   5398 C  CA  . PHE A 1 884 ? 170.043 138.557 146.515 1.00 33.24  ? 874  PHE A CA  1 
ATOM   5399 C  C   . PHE A 1 884 ? 169.438 139.625 147.414 1.00 33.24  ? 874  PHE A C   1 
ATOM   5400 O  O   . PHE A 1 884 ? 169.368 139.450 148.636 1.00 33.24  ? 874  PHE A O   1 
ATOM   5401 C  CB  . PHE A 1 884 ? 171.483 138.924 146.170 1.00 33.24  ? 874  PHE A CB  1 
ATOM   5402 C  CG  . PHE A 1 884 ? 172.318 139.251 147.369 1.00 33.24  ? 874  PHE A CG  1 
ATOM   5403 C  CD1 . PHE A 1 884 ? 172.709 138.254 148.243 1.00 33.24  ? 874  PHE A CD1 1 
ATOM   5404 C  CD2 . PHE A 1 884 ? 172.683 140.557 147.642 1.00 33.24  ? 874  PHE A CD2 1 
ATOM   5405 C  CE1 . PHE A 1 884 ? 173.473 138.550 149.352 1.00 33.24  ? 874  PHE A CE1 1 
ATOM   5406 C  CE2 . PHE A 1 884 ? 173.446 140.860 148.749 1.00 33.24  ? 874  PHE A CE2 1 
ATOM   5407 C  CZ  . PHE A 1 884 ? 173.841 139.856 149.606 1.00 33.24  ? 874  PHE A CZ  1 
ATOM   5408 N  N   . SER A 1 885 ? 169.002 140.742 146.827 1.00 29.44  ? 875  SER A N   1 
ATOM   5409 C  CA  . SER A 1 885 ? 168.436 141.824 147.623 1.00 29.44  ? 875  SER A CA  1 
ATOM   5410 C  C   . SER A 1 885 ? 167.140 141.399 148.298 1.00 29.44  ? 875  SER A C   1 
ATOM   5411 O  O   . SER A 1 885 ? 166.917 141.715 149.472 1.00 29.44  ? 875  SER A O   1 
ATOM   5412 C  CB  . SER A 1 885 ? 168.205 143.057 146.752 1.00 29.44  ? 875  SER A CB  1 
ATOM   5413 O  OG  . SER A 1 885 ? 167.979 144.203 147.554 1.00 29.44  ? 875  SER A OG  1 
ATOM   5414 N  N   . VAL A 1 886 ? 166.277 140.674 147.584 1.00 28.82  ? 876  VAL A N   1 
ATOM   5415 C  CA  . VAL A 1 886 ? 165.014 140.259 148.187 1.00 28.82  ? 876  VAL A CA  1 
ATOM   5416 C  C   . VAL A 1 886 ? 165.248 139.194 149.258 1.00 28.82  ? 876  VAL A C   1 
ATOM   5417 O  O   . VAL A 1 886 ? 164.569 139.185 150.294 1.00 28.82  ? 876  VAL A O   1 
ATOM   5418 C  CB  . VAL A 1 886 ? 164.012 139.811 147.103 1.00 28.82  ? 876  VAL A CB  1 
ATOM   5419 C  CG1 . VAL A 1 886 ? 164.402 138.500 146.451 1.00 28.82  ? 876  VAL A CG1 1 
ATOM   5420 C  CG2 . VAL A 1 886 ? 162.637 139.704 147.691 1.00 28.82  ? 876  VAL A CG2 1 
ATOM   5421 N  N   . THR A 1 887 ? 166.233 138.309 149.055 1.00 29.27  ? 877  THR A N   1 
ATOM   5422 C  CA  . THR A 1 887 ? 166.568 137.334 150.091 1.00 29.27  ? 877  THR A CA  1 
ATOM   5423 C  C   . THR A 1 887 ? 167.106 138.022 151.341 1.00 29.27  ? 877  THR A C   1 
ATOM   5424 O  O   . THR A 1 887 ? 166.716 137.681 152.467 1.00 29.27  ? 877  THR A O   1 
ATOM   5425 C  CB  . THR A 1 887 ? 167.581 136.326 149.547 1.00 29.27  ? 877  THR A CB  1 
ATOM   5426 O  OG1 . THR A 1 887 ? 166.954 135.512 148.550 1.00 29.27  ? 877  THR A OG1 1 
ATOM   5427 C  CG2 . THR A 1 887 ? 168.110 135.432 150.657 1.00 29.27  ? 877  THR A CG2 1 
ATOM   5428 N  N   . LEU A 1 888 ? 167.988 139.009 151.159 1.00 27.93  ? 878  LEU A N   1 
ATOM   5429 C  CA  . LEU A 1 888 ? 168.526 139.753 152.292 1.00 27.93  ? 878  LEU A CA  1 
ATOM   5430 C  C   . LEU A 1 888 ? 167.429 140.511 153.027 1.00 27.93  ? 878  LEU A C   1 
ATOM   5431 O  O   . LEU A 1 888 ? 167.421 140.560 154.265 1.00 27.93  ? 878  LEU A O   1 
ATOM   5432 C  CB  . LEU A 1 888 ? 169.611 140.714 151.813 1.00 27.93  ? 878  LEU A CB  1 
ATOM   5433 C  CG  . LEU A 1 888 ? 170.651 141.153 152.839 1.00 27.93  ? 878  LEU A CG  1 
ATOM   5434 C  CD1 . LEU A 1 888 ? 171.306 139.946 153.479 1.00 27.93  ? 878  LEU A CD1 1 
ATOM   5435 C  CD2 . LEU A 1 888 ? 171.687 142.039 152.179 1.00 27.93  ? 878  LEU A CD2 1 
ATOM   5436 N  N   . PHE A 1 889 ? 166.495 141.111 152.284 1.00 23.72  ? 879  PHE A N   1 
ATOM   5437 C  CA  . PHE A 1 889 ? 165.393 141.817 152.926 1.00 23.72  ? 879  PHE A CA  1 
ATOM   5438 C  C   . PHE A 1 889 ? 164.515 140.865 153.722 1.00 23.72  ? 879  PHE A C   1 
ATOM   5439 O  O   . PHE A 1 889 ? 164.071 141.207 154.820 1.00 23.72  ? 879  PHE A O   1 
ATOM   5440 C  CB  . PHE A 1 889 ? 164.551 142.571 151.899 1.00 23.72  ? 879  PHE A CB  1 
ATOM   5441 C  CG  . PHE A 1 889 ? 163.203 142.986 152.421 1.00 23.72  ? 879  PHE A CG  1 
ATOM   5442 C  CD1 . PHE A 1 889 ? 163.086 144.069 153.272 1.00 23.72  ? 879  PHE A CD1 1 
ATOM   5443 C  CD2 . PHE A 1 889 ? 162.057 142.298 152.062 1.00 23.72  ? 879  PHE A CD2 1 
ATOM   5444 C  CE1 . PHE A 1 889 ? 161.856 144.453 153.760 1.00 23.72  ? 879  PHE A CE1 1 
ATOM   5445 C  CE2 . PHE A 1 889 ? 160.826 142.680 152.549 1.00 23.72  ? 879  PHE A CE2 1 
ATOM   5446 C  CZ  . PHE A 1 889 ? 160.726 143.758 153.397 1.00 23.72  ? 879  PHE A CZ  1 
ATOM   5447 N  N   . THR A 1 890 ? 164.237 139.675 153.183 1.00 27.22  ? 880  THR A N   1 
ATOM   5448 C  CA  . THR A 1 890 ? 163.435 138.706 153.928 1.00 27.22  ? 880  THR A CA  1 
ATOM   5449 C  C   . THR A 1 890 ? 164.142 138.269 155.209 1.00 27.22  ? 880  THR A C   1 
ATOM   5450 O  O   . THR A 1 890 ? 163.523 138.207 156.286 1.00 27.22  ? 880  THR A O   1 
ATOM   5451 C  CB  . THR A 1 890 ? 163.126 137.500 153.041 1.00 27.22  ? 880  THR A CB  1 
ATOM   5452 O  OG1 . THR A 1 890 ? 162.457 137.940 151.854 1.00 27.22  ? 880  THR A OG1 1 
ATOM   5453 C  CG2 . THR A 1 890 ? 162.238 136.514 153.769 1.00 27.22  ? 880  THR A CG2 1 
ATOM   5454 N  N   . ILE A 1 891 ? 165.447 137.996 155.113 1.00 31.31  ? 881  ILE A N   1 
ATOM   5455 C  CA  . ILE A 1 891 ? 166.218 137.560 156.276 1.00 31.31  ? 881  ILE A CA  1 
ATOM   5456 C  C   . ILE A 1 891 ? 166.234 138.643 157.349 1.00 31.31  ? 881  ILE A C   1 
ATOM   5457 O  O   . ILE A 1 891 ? 166.048 138.360 158.539 1.00 31.31  ? 881  ILE A O   1 
ATOM   5458 C  CB  . ILE A 1 891 ? 167.643 137.157 155.849 1.00 31.31  ? 881  ILE A CB  1 
ATOM   5459 C  CG1 . ILE A 1 891 ? 167.611 135.861 155.038 1.00 31.31  ? 881  ILE A CG1 1 
ATOM   5460 C  CG2 . ILE A 1 891 ? 168.552 136.996 157.057 1.00 31.31  ? 881  ILE A CG2 1 
ATOM   5461 C  CD1 . ILE A 1 891 ? 167.004 134.693 155.776 1.00 31.31  ? 881  ILE A CD1 1 
ATOM   5462 N  N   . PHE A 1 892 ? 166.431 139.901 156.948 1.00 33.20  ? 882  PHE A N   1 
ATOM   5463 C  CA  . PHE A 1 892 ? 166.458 140.979 157.931 1.00 33.20  ? 882  PHE A CA  1 
ATOM   5464 C  C   . PHE A 1 892 ? 165.061 141.320 158.447 1.00 33.20  ? 882  PHE A C   1 
ATOM   5465 O  O   . PHE A 1 892 ? 164.918 141.788 159.583 1.00 33.20  ? 882  PHE A O   1 
ATOM   5466 C  CB  . PHE A 1 892 ? 167.123 142.219 157.336 1.00 33.20  ? 882  PHE A CB  1 
ATOM   5467 C  CG  . PHE A 1 892 ? 168.615 142.110 157.195 1.00 33.20  ? 882  PHE A CG  1 
ATOM   5468 C  CD1 . PHE A 1 892 ? 169.304 141.031 157.721 1.00 33.20  ? 882  PHE A CD1 1 
ATOM   5469 C  CD2 . PHE A 1 892 ? 169.330 143.102 156.546 1.00 33.20  ? 882  PHE A CD2 1 
ATOM   5470 C  CE1 . PHE A 1 892 ? 170.673 140.939 157.591 1.00 33.20  ? 882  PHE A CE1 1 
ATOM   5471 C  CE2 . PHE A 1 892 ? 170.698 143.016 156.415 1.00 33.20  ? 882  PHE A CE2 1 
ATOM   5472 C  CZ  . PHE A 1 892 ? 171.370 141.934 156.938 1.00 33.20  ? 882  PHE A CZ  1 
ATOM   5473 N  N   . ALA A 1 893 ? 164.023 141.087 157.641 1.00 31.30  ? 883  ALA A N   1 
ATOM   5474 C  CA  . ALA A 1 893 ? 162.662 141.364 158.082 1.00 31.30  ? 883  ALA A CA  1 
ATOM   5475 C  C   . ALA A 1 893 ? 162.222 140.378 159.151 1.00 31.30  ? 883  ALA A C   1 
ATOM   5476 O  O   . ALA A 1 893 ? 161.479 140.745 160.070 1.00 31.30  ? 883  ALA A O   1 
ATOM   5477 C  CB  . ALA A 1 893 ? 161.705 141.325 156.893 1.00 31.30  ? 883  ALA A CB  1 
ATOM   5478 N  N   . PHE A 1 894 ? 162.665 139.122 159.046 1.00 35.57  ? 884  PHE A N   1 
ATOM   5479 C  CA  . PHE A 1 894 ? 162.392 138.172 160.123 1.00 35.57  ? 884  PHE A CA  1 
ATOM   5480 C  C   . PHE A 1 894 ? 163.016 138.632 161.438 1.00 35.57  ? 884  PHE A C   1 
ATOM   5481 O  O   . PHE A 1 894 ? 162.382 138.548 162.498 1.00 35.57  ? 884  PHE A O   1 
ATOM   5482 C  CB  . PHE A 1 894 ? 162.893 136.779 159.748 1.00 35.57  ? 884  PHE A CB  1 
ATOM   5483 C  CG  . PHE A 1 894 ? 161.986 136.046 158.807 1.00 35.57  ? 884  PHE A CG  1 
ATOM   5484 C  CD1 . PHE A 1 894 ? 160.627 135.965 159.062 1.00 35.57  ? 884  PHE A CD1 1 
ATOM   5485 C  CD2 . PHE A 1 894 ? 162.489 135.421 157.680 1.00 35.57  ? 884  PHE A CD2 1 
ATOM   5486 C  CE1 . PHE A 1 894 ? 159.786 135.288 158.204 1.00 35.57  ? 884  PHE A CE1 1 
ATOM   5487 C  CE2 . PHE A 1 894 ? 161.652 134.740 156.819 1.00 35.57  ? 884  PHE A CE2 1 
ATOM   5488 C  CZ  . PHE A 1 894 ? 160.299 134.675 157.081 1.00 35.57  ? 884  PHE A CZ  1 
ATOM   5489 N  N   . ILE A 1 895 ? 164.249 139.142 161.383 1.00 34.85  ? 885  ILE A N   1 
ATOM   5490 C  CA  . ILE A 1 895 ? 164.917 139.651 162.579 1.00 34.85  ? 885  ILE A CA  1 
ATOM   5491 C  C   . ILE A 1 895 ? 164.174 140.859 163.137 1.00 34.85  ? 885  ILE A C   1 
ATOM   5492 O  O   . ILE A 1 895 ? 164.008 140.993 164.356 1.00 34.85  ? 885  ILE A O   1 
ATOM   5493 C  CB  . ILE A 1 895 ? 166.388 139.979 162.260 1.00 34.85  ? 885  ILE A CB  1 
ATOM   5494 C  CG1 . ILE A 1 895 ? 167.198 138.691 162.116 1.00 34.85  ? 885  ILE A CG1 1 
ATOM   5495 C  CG2 . ILE A 1 895 ? 167.001 140.868 163.328 1.00 34.85  ? 885  ILE A CG2 1 
ATOM   5496 C  CD1 . ILE A 1 895 ? 168.460 138.853 161.302 1.00 34.85  ? 885  ILE A CD1 1 
ATOM   5497 N  N   . ASN A 1 896 ? 163.722 141.757 162.258 1.00 38.00  ? 886  ASN A N   1 
ATOM   5498 C  CA  . ASN A 1 896 ? 162.966 142.930 162.698 1.00 38.00  ? 886  ASN A CA  1 
ATOM   5499 C  C   . ASN A 1 896 ? 161.675 142.519 163.404 1.00 38.00  ? 886  ASN A C   1 
ATOM   5500 O  O   . ASN A 1 896 ? 161.334 143.062 164.464 1.00 38.00  ? 886  ASN A O   1 
ATOM   5501 C  CB  . ASN A 1 896 ? 162.671 143.830 161.495 1.00 38.00  ? 886  ASN A CB  1 
ATOM   5502 C  CG  . ASN A 1 896 ? 162.081 145.182 161.882 1.00 38.00  ? 886  ASN A CG  1 
ATOM   5503 O  OD1 . ASN A 1 896 ? 161.737 145.430 163.033 1.00 38.00  ? 886  ASN A OD1 1 
ATOM   5504 N  ND2 . ASN A 1 896 ? 161.965 146.066 160.901 1.00 38.00  ? 886  ASN A ND2 1 
ATOM   5505 N  N   . VAL A 1 897 ? 160.950 141.554 162.833 1.00 42.06  ? 887  VAL A N   1 
ATOM   5506 C  CA  . VAL A 1 897 ? 159.716 141.078 163.455 1.00 42.06  ? 887  VAL A CA  1 
ATOM   5507 C  C   . VAL A 1 897 ? 160.010 140.440 164.809 1.00 42.06  ? 887  VAL A C   1 
ATOM   5508 O  O   . VAL A 1 897 ? 159.286 140.664 165.788 1.00 42.06  ? 887  VAL A O   1 
ATOM   5509 C  CB  . VAL A 1 897 ? 158.981 140.109 162.509 1.00 42.06  ? 887  VAL A CB  1 
ATOM   5510 C  CG1 . VAL A 1 897 ? 157.849 139.396 163.230 1.00 42.06  ? 887  VAL A CG1 1 
ATOM   5511 C  CG2 . VAL A 1 897 ? 158.443 140.862 161.309 1.00 42.06  ? 887  VAL A CG2 1 
ATOM   5512 N  N   . GLY A 1 898 ? 161.082 139.647 164.888 1.00 43.62  ? 888  GLY A N   1 
ATOM   5513 C  CA  . GLY A 1 898 ? 161.448 139.036 166.157 1.00 43.62  ? 888  GLY A CA  1 
ATOM   5514 C  C   . GLY A 1 898 ? 161.790 140.057 167.225 1.00 43.62  ? 888  GLY A C   1 
ATOM   5515 O  O   . GLY A 1 898 ? 161.378 139.929 168.380 1.00 43.62  ? 888  GLY A O   1 
ATOM   5516 N  N   . VAL A 1 899 ? 162.543 141.092 166.850 1.00 44.35  ? 889  VAL A N   1 
ATOM   5517 C  CA  . VAL A 1 899 ? 162.924 142.121 167.814 1.00 44.35  ? 889  VAL A CA  1 
ATOM   5518 C  C   . VAL A 1 899 ? 161.701 142.914 168.263 1.00 44.35  ? 889  VAL A C   1 
ATOM   5519 O  O   . VAL A 1 899 ? 161.576 143.268 169.442 1.00 44.35  ? 889  VAL A O   1 
ATOM   5520 C  CB  . VAL A 1 899 ? 164.018 143.029 167.221 1.00 44.35  ? 889  VAL A CB  1 
ATOM   5521 C  CG1 . VAL A 1 899 ? 164.235 144.268 168.080 1.00 44.35  ? 889  VAL A CG1 1 
ATOM   5522 C  CG2 . VAL A 1 899 ? 165.318 142.257 167.092 1.00 44.35  ? 889  VAL A CG2 1 
ATOM   5523 N  N   . LEU A 1 900 ? 160.769 143.186 167.343 1.00 51.48  ? 890  LEU A N   1 
ATOM   5524 C  CA  . LEU A 1 900 ? 159.536 143.867 167.730 1.00 51.48  ? 890  LEU A CA  1 
ATOM   5525 C  C   . LEU A 1 900 ? 158.703 143.014 168.681 1.00 51.48  ? 890  LEU A C   1 
ATOM   5526 O  O   . LEU A 1 900 ? 158.122 143.530 169.642 1.00 51.48  ? 890  LEU A O   1 
ATOM   5527 C  CB  . LEU A 1 900 ? 158.719 144.239 166.493 1.00 51.48  ? 890  LEU A CB  1 
ATOM   5528 C  CG  . LEU A 1 900 ? 158.994 145.606 165.863 1.00 51.48  ? 890  LEU A CG  1 
ATOM   5529 C  CD1 . LEU A 1 900 ? 157.839 146.011 164.963 1.00 51.48  ? 890  LEU A CD1 1 
ATOM   5530 C  CD2 . LEU A 1 900 ? 159.245 146.666 166.925 1.00 51.48  ? 890  LEU A CD2 1 
ATOM   5531 N  N   . LEU A 1 901 ? 158.633 141.705 168.429 1.00 57.04  ? 891  LEU A N   1 
ATOM   5532 C  CA  . LEU A 1 901 ? 157.885 140.825 169.321 1.00 57.04  ? 891  LEU A CA  1 
ATOM   5533 C  C   . LEU A 1 901 ? 158.577 140.661 170.668 1.00 57.04  ? 891  LEU A C   1 
ATOM   5534 O  O   . LEU A 1 901 ? 157.915 140.358 171.667 1.00 57.04  ? 891  LEU A O   1 
ATOM   5535 C  CB  . LEU A 1 901 ? 157.678 139.462 168.665 1.00 57.04  ? 891  LEU A CB  1 
ATOM   5536 C  CG  . LEU A 1 901 ? 156.322 139.238 167.999 1.00 57.04  ? 891  LEU A CG  1 
ATOM   5537 C  CD1 . LEU A 1 901 ? 156.204 137.800 167.537 1.00 57.04  ? 891  LEU A CD1 1 
ATOM   5538 C  CD2 . LEU A 1 901 ? 155.192 139.593 168.947 1.00 57.04  ? 891  LEU A CD2 1 
ATOM   5539 N  N   . TYR A 1 902 ? 159.901 140.837 170.712 1.00 65.41  ? 892  TYR A N   1 
ATOM   5540 C  CA  . TYR A 1 902 ? 160.625 140.742 171.976 1.00 65.41  ? 892  TYR A CA  1 
ATOM   5541 C  C   . TYR A 1 902 ? 160.198 141.823 172.960 1.00 65.41  ? 892  TYR A C   1 
ATOM   5542 O  O   . TYR A 1 902 ? 160.267 141.617 174.177 1.00 65.41  ? 892  TYR A O   1 
ATOM   5543 C  CB  . TYR A 1 902 ? 162.131 140.823 171.724 1.00 65.41  ? 892  TYR A CB  1 
ATOM   5544 C  CG  . TYR A 1 902 ? 162.968 140.862 172.984 1.00 65.41  ? 892  TYR A CG  1 
ATOM   5545 C  CD1 . TYR A 1 902 ? 163.034 139.764 173.832 1.00 65.41  ? 892  TYR A CD1 1 
ATOM   5546 C  CD2 . TYR A 1 902 ? 163.687 142.000 173.327 1.00 65.41  ? 892  TYR A CD2 1 
ATOM   5547 C  CE1 . TYR A 1 902 ? 163.796 139.797 174.986 1.00 65.41  ? 892  TYR A CE1 1 
ATOM   5548 C  CE2 . TYR A 1 902 ? 164.451 142.043 174.477 1.00 65.41  ? 892  TYR A CE2 1 
ATOM   5549 C  CZ  . TYR A 1 902 ? 164.503 140.940 175.303 1.00 65.41  ? 892  TYR A CZ  1 
ATOM   5550 O  OH  . TYR A 1 902 ? 165.263 140.978 176.450 1.00 65.41  ? 892  TYR A OH  1 
ATOM   5551 N  N   . ARG A 1 903 ? 159.744 142.969 172.461 1.00 65.72  ? 893  ARG A N   1 
ATOM   5552 C  CA  . ARG A 1 903 ? 159.330 144.072 173.319 1.00 65.72  ? 893  ARG A CA  1 
ATOM   5553 C  C   . ARG A 1 903 ? 157.950 143.866 173.933 1.00 65.72  ? 893  ARG A C   1 
ATOM   5554 O  O   . ARG A 1 903 ? 157.514 144.707 174.727 1.00 65.72  ? 893  ARG A O   1 
ATOM   5555 C  CB  . ARG A 1 903 ? 159.366 145.383 172.529 1.00 65.72  ? 893  ARG A CB  1 
ATOM   5556 C  CG  . ARG A 1 903 ? 160.764 145.794 172.091 1.00 65.72  ? 893  ARG A CG  1 
ATOM   5557 C  CD  . ARG A 1 903 ? 160.737 147.062 171.260 1.00 65.72  ? 893  ARG A CD  1 
ATOM   5558 N  NE  . ARG A 1 903 ? 160.494 148.250 172.068 1.00 65.72  ? 893  ARG A NE  1 
ATOM   5559 C  CZ  . ARG A 1 903 ? 161.448 148.981 172.626 1.00 65.72  ? 893  ARG A CZ  1 
ATOM   5560 N  NH1 . ARG A 1 903 ? 162.727 148.677 172.481 1.00 65.72  ? 893  ARG A NH1 1 
ATOM   5561 N  NH2 . ARG A 1 903 ? 161.111 150.049 173.343 1.00 65.72  ? 893  ARG A NH2 1 
ATOM   5562 N  N   . ARG A 1 904 ? 157.258 142.775 173.595 1.00 70.35  ? 894  ARG A N   1 
ATOM   5563 C  CA  . ARG A 1 904 ? 155.948 142.483 174.168 1.00 70.35  ? 894  ARG A CA  1 
ATOM   5564 C  C   . ARG A 1 904 ? 156.012 142.061 175.630 1.00 70.35  ? 894  ARG A C   1 
ATOM   5565 O  O   . ARG A 1 904 ? 154.958 141.944 176.264 1.00 70.35  ? 894  ARG A O   1 
ATOM   5566 C  CB  . ARG A 1 904 ? 155.250 141.390 173.358 1.00 70.35  ? 894  ARG A CB  1 
ATOM   5567 C  CG  . ARG A 1 904 ? 154.784 141.848 171.997 1.00 70.35  ? 894  ARG A CG  1 
ATOM   5568 C  CD  . ARG A 1 904 ? 153.705 142.896 172.147 1.00 70.35  ? 894  ARG A CD  1 
ATOM   5569 N  NE  . ARG A 1 904 ? 152.462 142.349 172.676 1.00 70.35  ? 894  ARG A NE  1 
ATOM   5570 C  CZ  . ARG A 1 904 ? 151.399 142.061 171.939 1.00 70.35  ? 894  ARG A CZ  1 
ATOM   5571 N  NH1 . ARG A 1 904 ? 151.383 142.277 170.635 1.00 70.35  ? 894  ARG A NH1 1 
ATOM   5572 N  NH2 . ARG A 1 904 ? 150.319 141.554 172.527 1.00 70.35  ? 894  ARG A NH2 1 
ATOM   5573 N  N   . ARG A 1 905 ? 157.204 141.815 176.167 1.00 82.87  ? 895  ARG A N   1 
ATOM   5574 C  CA  . ARG A 1 905 ? 157.332 141.424 177.563 1.00 82.87  ? 895  ARG A CA  1 
ATOM   5575 C  C   . ARG A 1 905 ? 156.891 142.571 178.471 1.00 82.87  ? 895  ARG A C   1 
ATOM   5576 O  O   . ARG A 1 905 ? 157.112 143.741 178.144 1.00 82.87  ? 895  ARG A O   1 
ATOM   5577 C  CB  . ARG A 1 905 ? 158.776 141.033 177.876 1.00 82.87  ? 895  ARG A CB  1 
ATOM   5578 C  CG  . ARG A 1 905 ? 159.291 139.868 177.048 1.00 82.87  ? 895  ARG A CG  1 
ATOM   5579 C  CD  . ARG A 1 905 ? 160.758 139.580 177.326 1.00 82.87  ? 895  ARG A CD  1 
ATOM   5580 N  NE  . ARG A 1 905 ? 160.973 139.027 178.658 1.00 82.87  ? 895  ARG A NE  1 
ATOM   5581 C  CZ  . ARG A 1 905 ? 161.589 139.663 179.645 1.00 82.87  ? 895  ARG A CZ  1 
ATOM   5582 N  NH1 . ARG A 1 905 ? 162.062 140.889 179.489 1.00 82.87  ? 895  ARG A NH1 1 
ATOM   5583 N  NH2 . ARG A 1 905 ? 161.737 139.053 180.818 1.00 82.87  ? 895  ARG A NH2 1 
ATOM   5584 N  N   . PRO A 1 906 ? 156.249 142.269 179.604 1.00 83.63  ? 896  PRO A N   1 
ATOM   5585 C  CA  . PRO A 1 906 ? 155.838 143.342 180.526 1.00 83.63  ? 896  PRO A CA  1 
ATOM   5586 C  C   . PRO A 1 906 ? 157.000 144.128 181.107 1.00 83.63  ? 896  PRO A C   1 
ATOM   5587 O  O   . PRO A 1 906 ? 156.796 145.261 181.561 1.00 83.63  ? 896  PRO A O   1 
ATOM   5588 C  CB  . PRO A 1 906 ? 155.070 142.589 181.622 1.00 83.63  ? 896  PRO A CB  1 
ATOM   5589 C  CG  . PRO A 1 906 ? 154.641 141.310 180.978 1.00 83.63  ? 896  PRO A CG  1 
ATOM   5590 C  CD  . PRO A 1 906 ? 155.739 140.953 180.022 1.00 83.63  ? 896  PRO A CD  1 
ATOM   5591 N  N   . GLU A 1 907 ? 158.207 143.558 181.119 1.00 88.28  ? 897  GLU A N   1 
ATOM   5592 C  CA  . GLU A 1 907 ? 159.379 144.305 181.559 1.00 88.28  ? 897  GLU A CA  1 
ATOM   5593 C  C   . GLU A 1 907 ? 159.688 145.457 180.611 1.00 88.28  ? 897  GLU A C   1 
ATOM   5594 O  O   . GLU A 1 907 ? 160.077 146.544 181.053 1.00 88.28  ? 897  GLU A O   1 
ATOM   5595 C  CB  . GLU A 1 907 ? 160.583 143.368 181.678 1.00 88.28  ? 897  GLU A CB  1 
ATOM   5596 C  CG  . GLU A 1 907 ? 160.457 142.295 182.760 1.00 88.28  ? 897  GLU A CG  1 
ATOM   5597 C  CD  . GLU A 1 907 ? 159.689 141.062 182.305 1.00 88.28  ? 897  GLU A CD  1 
ATOM   5598 O  OE1 . GLU A 1 907 ? 159.054 141.104 181.230 1.00 88.28  ? 897  GLU A OE1 1 
ATOM   5599 O  OE2 . GLU A 1 907 ? 159.722 140.046 183.030 1.00 88.28  ? 897  GLU A OE2 1 
ATOM   5600 N  N   . ILE A 1 908 ? 159.529 145.234 179.304 1.00 85.60  ? 898  ILE A N   1 
ATOM   5601 C  CA  . ILE A 1 908 ? 159.808 146.283 178.327 1.00 85.60  ? 898  ILE A CA  1 
ATOM   5602 C  C   . ILE A 1 908 ? 158.763 147.390 178.414 1.00 85.60  ? 898  ILE A C   1 
ATOM   5603 O  O   . ILE A 1 908 ? 159.096 148.580 178.462 1.00 85.60  ? 898  ILE A O   1 
ATOM   5604 C  CB  . ILE A 1 908 ? 159.881 145.687 176.910 1.00 85.60  ? 898  ILE A CB  1 
ATOM   5605 C  CG1 . ILE A 1 908 ? 161.027 144.679 176.815 1.00 85.60  ? 898  ILE A CG1 1 
ATOM   5606 C  CG2 . ILE A 1 908 ? 160.054 146.788 175.878 1.00 85.60  ? 898  ILE A CG2 1 
ATOM   5607 C  CD1 . ILE A 1 908 ? 162.397 145.292 177.013 1.00 85.60  ? 898  ILE A CD1 1 
ATOM   5608 N  N   . GLY A 1 909 ? 157.482 147.015 178.444 1.00 80.69  ? 899  GLY A N   1 
ATOM   5609 C  CA  . GLY A 1 909 ? 156.380 147.955 178.564 1.00 80.69  ? 899  GLY A CA  1 
ATOM   5610 C  C   . GLY A 1 909 ? 155.432 147.945 177.380 1.00 80.69  ? 899  GLY A C   1 
ATOM   5611 O  O   . GLY A 1 909 ? 154.218 148.080 177.565 1.00 80.69  ? 899  GLY A O   1 
ATOM   5612 N  N   . GLY A 1 910 ? 155.959 147.786 176.172 1.00 72.83  ? 900  GLY A N   1 
ATOM   5613 C  CA  . GLY A 1 910 ? 155.108 147.796 174.997 1.00 72.83  ? 900  GLY A CA  1 
ATOM   5614 C  C   . GLY A 1 910 ? 155.926 147.621 173.737 1.00 72.83  ? 900  GLY A C   1 
ATOM   5615 O  O   . GLY A 1 910 ? 157.153 147.484 173.776 1.00 72.83  ? 900  GLY A O   1 
ATOM   5616 N  N   . GLU A 1 911 ? 155.213 147.621 172.608 1.00 63.69  ? 901  GLU A N   1 
ATOM   5617 C  CA  . GLU A 1 911 ? 155.860 147.430 171.313 1.00 63.69  ? 901  GLU A CA  1 
ATOM   5618 C  C   . GLU A 1 911 ? 156.757 148.605 170.955 1.00 63.69  ? 901  GLU A C   1 
ATOM   5619 O  O   . GLU A 1 911 ? 157.857 148.414 170.426 1.00 63.69  ? 901  GLU A O   1 
ATOM   5620 C  CB  . GLU A 1 911 ? 154.807 147.232 170.225 1.00 63.69  ? 901  GLU A CB  1 
ATOM   5621 C  CG  . GLU A 1 911 ? 154.054 145.935 170.339 1.00 63.69  ? 901  GLU A CG  1 
ATOM   5622 C  CD  . GLU A 1 911 ? 154.502 144.911 169.322 1.00 63.69  ? 901  GLU A CD  1 
ATOM   5623 O  OE1 . GLU A 1 911 ? 155.680 144.961 168.911 1.00 63.69  ? 901  GLU A OE1 1 
ATOM   5624 O  OE2 . GLU A 1 911 ? 153.687 144.041 168.953 1.00 63.69  ? 901  GLU A OE2 1 
ATOM   5625 N  N   . LEU A 1 912 ? 156.305 149.824 171.227 1.00 54.76  ? 902  LEU A N   1 
ATOM   5626 C  CA  . LEU A 1 912 ? 156.966 151.026 170.744 1.00 54.76  ? 902  LEU A CA  1 
ATOM   5627 C  C   . LEU A 1 912 ? 157.258 151.940 171.922 1.00 54.76  ? 902  LEU A C   1 
ATOM   5628 O  O   . LEU A 1 912 ? 156.378 152.192 172.750 1.00 54.76  ? 902  LEU A O   1 
ATOM   5629 C  CB  . LEU A 1 912 ? 156.087 151.734 169.708 1.00 54.76  ? 902  LEU A CB  1 
ATOM   5630 C  CG  . LEU A 1 912 ? 156.185 151.184 168.283 1.00 54.76  ? 902  LEU A CG  1 
ATOM   5631 C  CD1 . LEU A 1 912 ? 154.889 151.389 167.538 1.00 54.76  ? 902  LEU A CD1 1 
ATOM   5632 C  CD2 . LEU A 1 912 ? 157.305 151.841 167.525 1.00 54.76  ? 902  LEU A CD2 1 
ATOM   5633 N  N   . GLY A 1 913 ? 158.489 152.433 171.996 1.00 64.43  ? 903  GLY A N   1 
ATOM   5634 C  CA  . GLY A 1 913 ? 158.871 153.321 173.072 1.00 64.43  ? 903  GLY A CA  1 
ATOM   5635 C  C   . GLY A 1 913 ? 159.158 152.586 174.371 1.00 64.43  ? 903  GLY A C   1 
ATOM   5636 O  O   . GLY A 1 913 ? 159.325 151.363 174.414 1.00 64.43  ? 903  GLY A O   1 
ATOM   5637 N  N   . GLY A 1 914 ? 159.216 153.364 175.450 1.00 68.51  ? 904  GLY A N   1 
ATOM   5638 C  CA  . GLY A 1 914 ? 159.501 152.834 176.763 1.00 68.51  ? 904  GLY A CA  1 
ATOM   5639 C  C   . GLY A 1 914 ? 160.674 153.532 177.421 1.00 68.51  ? 904  GLY A C   1 
ATOM   5640 O  O   . GLY A 1 914 ? 160.800 154.760 177.373 1.00 68.51  ? 904  GLY A O   1 
ATOM   5641 N  N   . PRO A 1 915 ? 161.550 152.761 178.061 1.00 68.75  ? 905  PRO A N   1 
ATOM   5642 C  CA  . PRO A 1 915 ? 162.761 153.350 178.640 1.00 68.75  ? 905  PRO A CA  1 
ATOM   5643 C  C   . PRO A 1 915 ? 163.715 153.825 177.557 1.00 68.75  ? 905  PRO A C   1 
ATOM   5644 O  O   . PRO A 1 915 ? 163.692 153.345 176.422 1.00 68.75  ? 905  PRO A O   1 
ATOM   5645 C  CB  . PRO A 1 915 ? 163.364 152.196 179.449 1.00 68.75  ? 905  PRO A CB  1 
ATOM   5646 C  CG  . PRO A 1 915 ? 162.857 150.967 178.773 1.00 68.75  ? 905  PRO A CG  1 
ATOM   5647 C  CD  . PRO A 1 915 ? 161.476 151.307 178.287 1.00 68.75  ? 905  PRO A CD  1 
ATOM   5648 N  N   . ARG A 1 916 ? 164.558 154.794 177.925 1.00 67.55  ? 906  ARG A N   1 
ATOM   5649 C  CA  . ARG A 1 916 ? 165.462 155.403 176.952 1.00 67.55  ? 906  ARG A CA  1 
ATOM   5650 C  C   . ARG A 1 916 ? 166.496 154.406 176.441 1.00 67.55  ? 906  ARG A C   1 
ATOM   5651 O  O   . ARG A 1 916 ? 166.859 154.436 175.259 1.00 67.55  ? 906  ARG A O   1 
ATOM   5652 C  CB  . ARG A 1 916 ? 166.144 156.627 177.566 1.00 67.55  ? 906  ARG A CB  1 
ATOM   5653 C  CG  . ARG A 1 916 ? 167.166 157.297 176.656 1.00 67.55  ? 906  ARG A CG  1 
ATOM   5654 C  CD  . ARG A 1 916 ? 167.106 158.810 176.762 1.00 67.55  ? 906  ARG A CD  1 
ATOM   5655 N  NE  . ARG A 1 916 ? 165.872 159.347 176.200 1.00 67.55  ? 906  ARG A NE  1 
ATOM   5656 C  CZ  . ARG A 1 916 ? 165.668 160.629 175.928 1.00 67.55  ? 906  ARG A CZ  1 
ATOM   5657 N  NH1 . ARG A 1 916 ? 166.599 161.541 176.157 1.00 67.55  ? 906  ARG A NH1 1 
ATOM   5658 N  NH2 . ARG A 1 916 ? 164.502 161.006 175.413 1.00 67.55  ? 906  ARG A NH2 1 
ATOM   5659 N  N   . THR A 1 917 ? 166.980 153.518 177.313 1.00 66.63  ? 907  THR A N   1 
ATOM   5660 C  CA  . THR A 1 917 ? 167.993 152.547 176.906 1.00 66.63  ? 907  THR A CA  1 
ATOM   5661 C  C   . THR A 1 917 ? 167.454 151.597 175.843 1.00 66.63  ? 907  THR A C   1 
ATOM   5662 O  O   . THR A 1 917 ? 168.118 151.339 174.831 1.00 66.63  ? 907  THR A O   1 
ATOM   5663 C  CB  . THR A 1 917 ? 168.488 151.763 178.122 1.00 66.63  ? 907  THR A CB  1 
ATOM   5664 O  OG1 . THR A 1 917 ? 167.389 151.070 178.725 1.00 66.63  ? 907  THR A OG1 1 
ATOM   5665 C  CG2 . THR A 1 917 ? 169.111 152.703 179.143 1.00 66.63  ? 907  THR A CG2 1 
ATOM   5666 N  N   . ALA A 1 918 ? 166.243 151.073 176.053 1.00 61.01  ? 908  ALA A N   1 
ATOM   5667 C  CA  . ALA A 1 918 ? 165.636 150.179 175.071 1.00 61.01  ? 908  ALA A CA  1 
ATOM   5668 C  C   . ALA A 1 918 ? 165.347 150.907 173.764 1.00 61.01  ? 908  ALA A C   1 
ATOM   5669 O  O   . ALA A 1 918 ? 165.548 150.348 172.678 1.00 61.01  ? 908  ALA A O   1 
ATOM   5670 C  CB  . ALA A 1 918 ? 164.359 149.563 175.639 1.00 61.01  ? 908  ALA A CB  1 
ATOM   5671 N  N   . LYS A 1 919 ? 164.876 152.156 173.854 1.00 57.28  ? 909  LYS A N   1 
ATOM   5672 C  CA  . LYS A 1 919 ? 164.645 152.973 172.665 1.00 57.28  ? 909  LYS A CA  1 
ATOM   5673 C  C   . LYS A 1 919 ? 165.919 153.122 171.844 1.00 57.28  ? 909  LYS A C   1 
ATOM   5674 O  O   . LYS A 1 919 ? 165.928 152.866 170.633 1.00 57.28  ? 909  LYS A O   1 
ATOM   5675 C  CB  . LYS A 1 919 ? 164.135 154.356 173.073 1.00 57.28  ? 909  LYS A CB  1 
ATOM   5676 C  CG  . LYS A 1 919 ? 162.668 154.452 173.437 1.00 57.28  ? 909  LYS A CG  1 
ATOM   5677 C  CD  . LYS A 1 919 ? 162.321 155.907 173.721 1.00 57.28  ? 909  LYS A CD  1 
ATOM   5678 C  CE  . LYS A 1 919 ? 160.902 156.073 174.221 1.00 57.28  ? 909  LYS A CE  1 
ATOM   5679 N  NZ  . LYS A 1 919 ? 160.612 157.491 174.568 1.00 57.28  ? 909  LYS A NZ  1 
ATOM   5680 N  N   . LEU A 1 920 ? 167.006 153.541 172.497 1.00 54.68  ? 910  LEU A N   1 
ATOM   5681 C  CA  . LEU A 1 920 ? 168.264 153.765 171.795 1.00 54.68  ? 910  LEU A CA  1 
ATOM   5682 C  C   . LEU A 1 920 ? 168.817 152.471 171.216 1.00 54.68  ? 910  LEU A C   1 
ATOM   5683 O  O   . LEU A 1 920 ? 169.298 152.455 170.077 1.00 54.68  ? 910  LEU A O   1 
ATOM   5684 C  CB  . LEU A 1 920 ? 169.280 154.410 172.735 1.00 54.68  ? 910  LEU A CB  1 
ATOM   5685 C  CG  . LEU A 1 920 ? 168.990 155.851 173.154 1.00 54.68  ? 910  LEU A CG  1 
ATOM   5686 C  CD1 . LEU A 1 920 ? 169.949 156.295 174.244 1.00 54.68  ? 910  LEU A CD1 1 
ATOM   5687 C  CD2 . LEU A 1 920 ? 169.087 156.773 171.954 1.00 54.68  ? 910  LEU A CD2 1 
ATOM   5688 N  N   . LEU A 1 921 ? 168.742 151.373 171.974 1.00 52.59  ? 911  LEU A N   1 
ATOM   5689 C  CA  . LEU A 1 921 ? 169.260 150.099 171.486 1.00 52.59  ? 911  LEU A CA  1 
ATOM   5690 C  C   . LEU A 1 921 ? 168.484 149.615 170.266 1.00 52.59  ? 911  LEU A C   1 
ATOM   5691 O  O   . LEU A 1 921 ? 169.079 149.200 169.264 1.00 52.59  ? 911  LEU A O   1 
ATOM   5692 C  CB  . LEU A 1 921 ? 169.221 149.052 172.600 1.00 52.59  ? 911  LEU A CB  1 
ATOM   5693 C  CG  . LEU A 1 921 ? 170.524 148.787 173.361 1.00 52.59  ? 911  LEU A CG  1 
ATOM   5694 C  CD1 . LEU A 1 921 ? 171.562 148.171 172.437 1.00 52.59  ? 911  LEU A CD1 1 
ATOM   5695 C  CD2 . LEU A 1 921 ? 171.065 150.055 174.006 1.00 52.59  ? 911  LEU A CD2 1 
ATOM   5696 N  N   . THR A 1 922 ? 167.150 149.683 170.324 1.00 48.49  ? 912  THR A N   1 
ATOM   5697 C  CA  . THR A 1 922 ? 166.336 149.213 169.208 1.00 48.49  ? 912  THR A CA  1 
ATOM   5698 C  C   . THR A 1 922 ? 166.530 150.085 167.972 1.00 48.49  ? 912  THR A C   1 
ATOM   5699 O  O   . THR A 1 922 ? 166.654 149.567 166.852 1.00 48.49  ? 912  THR A O   1 
ATOM   5700 C  CB  . THR A 1 922 ? 164.866 149.177 169.619 1.00 48.49  ? 912  THR A CB  1 
ATOM   5701 O  OG1 . THR A 1 922 ? 164.761 148.692 170.962 1.00 48.49  ? 912  THR A OG1 1 
ATOM   5702 C  CG2 . THR A 1 922 ? 164.094 148.245 168.715 1.00 48.49  ? 912  THR A CG2 1 
ATOM   5703 N  N   . SER A 1 923 ? 166.578 151.409 168.155 1.00 44.14  ? 913  SER A N   1 
ATOM   5704 C  CA  . SER A 1 923 ? 166.785 152.302 167.020 1.00 44.14  ? 913  SER A CA  1 
ATOM   5705 C  C   . SER A 1 923 ? 168.158 152.095 166.391 1.00 44.14  ? 913  SER A C   1 
ATOM   5706 O  O   . SER A 1 923 ? 168.285 152.064 165.159 1.00 44.14  ? 913  SER A O   1 
ATOM   5707 C  CB  . SER A 1 923 ? 166.606 153.754 167.461 1.00 44.14  ? 913  SER A CB  1 
ATOM   5708 O  OG  . SER A 1 923 ? 165.412 153.909 168.206 1.00 44.14  ? 913  SER A OG  1 
ATOM   5709 N  N   . CYS A 1 924 ? 169.198 151.944 167.218 1.00 43.91  ? 914  CYS A N   1 
ATOM   5710 C  CA  . CYS A 1 924 ? 170.538 151.717 166.688 1.00 43.91  ? 914  CYS A CA  1 
ATOM   5711 C  C   . CYS A 1 924 ? 170.621 150.387 165.954 1.00 43.91  ? 914  CYS A C   1 
ATOM   5712 O  O   . CYS A 1 924 ? 171.265 150.292 164.902 1.00 43.91  ? 914  CYS A O   1 
ATOM   5713 C  CB  . CYS A 1 924 ? 171.565 151.777 167.817 1.00 43.91  ? 914  CYS A CB  1 
ATOM   5714 S  SG  . CYS A 1 924 ? 171.949 153.451 168.380 1.00 43.91  ? 914  CYS A SG  1 
ATOM   5715 N  N   . LEU A 1 925 ? 169.960 149.351 166.483 1.00 41.65  ? 915  LEU A N   1 
ATOM   5716 C  CA  . LEU A 1 925 ? 169.936 148.062 165.800 1.00 41.65  ? 915  LEU A CA  1 
ATOM   5717 C  C   . LEU A 1 925 ? 169.253 148.168 164.442 1.00 41.65  ? 915  LEU A C   1 
ATOM   5718 O  O   . LEU A 1 925 ? 169.733 147.601 163.454 1.00 41.65  ? 915  LEU A O   1 
ATOM   5719 C  CB  . LEU A 1 925 ? 169.237 147.018 166.671 1.00 41.65  ? 915  LEU A CB  1 
ATOM   5720 C  CG  . LEU A 1 925 ? 168.779 145.731 165.982 1.00 41.65  ? 915  LEU A CG  1 
ATOM   5721 C  CD1 . LEU A 1 925 ? 169.968 144.925 165.478 1.00 41.65  ? 915  LEU A CD1 1 
ATOM   5722 C  CD2 . LEU A 1 925 ? 167.921 144.899 166.916 1.00 41.65  ? 915  LEU A CD2 1 
ATOM   5723 N  N   . PHE A 1 926 ? 168.137 148.898 164.368 1.00 40.27  ? 916  PHE A N   1 
ATOM   5724 C  CA  . PHE A 1 926 ? 167.435 149.020 163.092 1.00 40.27  ? 916  PHE A CA  1 
ATOM   5725 C  C   . PHE A 1 926 ? 168.244 149.815 162.071 1.00 40.27  ? 916  PHE A C   1 
ATOM   5726 O  O   . PHE A 1 926 ? 168.298 149.443 160.890 1.00 40.27  ? 916  PHE A O   1 
ATOM   5727 C  CB  . PHE A 1 926 ? 166.064 149.654 163.303 1.00 40.27  ? 916  PHE A CB  1 
ATOM   5728 C  CG  . PHE A 1 926 ? 165.083 148.744 163.968 1.00 40.27  ? 916  PHE A CG  1 
ATOM   5729 C  CD1 . PHE A 1 926 ? 165.184 147.375 163.815 1.00 40.27  ? 916  PHE A CD1 1 
ATOM   5730 C  CD2 . PHE A 1 926 ? 164.055 149.254 164.735 1.00 40.27  ? 916  PHE A CD2 1 
ATOM   5731 C  CE1 . PHE A 1 926 ? 164.287 146.532 164.424 1.00 40.27  ? 916  PHE A CE1 1 
ATOM   5732 C  CE2 . PHE A 1 926 ? 163.150 148.415 165.342 1.00 40.27  ? 916  PHE A CE2 1 
ATOM   5733 C  CZ  . PHE A 1 926 ? 163.267 147.053 165.190 1.00 40.27  ? 916  PHE A CZ  1 
ATOM   5734 N  N   . VAL A 1 927 ? 168.874 150.913 162.500 1.00 33.43  ? 917  VAL A N   1 
ATOM   5735 C  CA  . VAL A 1 927 ? 169.697 151.691 161.576 1.00 33.43  ? 917  VAL A CA  1 
ATOM   5736 C  C   . VAL A 1 927 ? 170.893 150.871 161.104 1.00 33.43  ? 917  VAL A C   1 
ATOM   5737 O  O   . VAL A 1 927 ? 171.274 150.922 159.926 1.00 33.43  ? 917  VAL A O   1 
ATOM   5738 C  CB  . VAL A 1 927 ? 170.127 153.020 162.224 1.00 33.43  ? 917  VAL A CB  1 
ATOM   5739 C  CG1 . VAL A 1 927 ? 171.014 153.812 161.282 1.00 33.43  ? 917  VAL A CG1 1 
ATOM   5740 C  CG2 . VAL A 1 927 ? 168.907 153.846 162.577 1.00 33.43  ? 917  VAL A CG2 1 
ATOM   5741 N  N   . LEU A 1 928 ? 171.486 150.080 162.004 1.00 38.34  ? 918  LEU A N   1 
ATOM   5742 C  CA  . LEU A 1 928 ? 172.584 149.202 161.612 1.00 38.34  ? 918  LEU A CA  1 
ATOM   5743 C  C   . LEU A 1 928 ? 172.122 148.144 160.616 1.00 38.34  ? 918  LEU A C   1 
ATOM   5744 O  O   . LEU A 1 928 ? 172.847 147.813 159.671 1.00 38.34  ? 918  LEU A O   1 
ATOM   5745 C  CB  . LEU A 1 928 ? 173.194 148.545 162.850 1.00 38.34  ? 918  LEU A CB  1 
ATOM   5746 C  CG  . LEU A 1 928 ? 174.407 147.642 162.620 1.00 38.34  ? 918  LEU A CG  1 
ATOM   5747 C  CD1 . LEU A 1 928 ? 175.574 148.443 162.068 1.00 38.34  ? 918  LEU A CD1 1 
ATOM   5748 C  CD2 . LEU A 1 928 ? 174.799 146.933 163.906 1.00 38.34  ? 918  LEU A CD2 1 
ATOM   5749 N  N   . LEU A 1 929 ? 170.917 147.602 160.815 1.00 33.89  ? 919  LEU A N   1 
ATOM   5750 C  CA  . LEU A 1 929 ? 170.377 146.618 159.881 1.00 33.89  ? 919  LEU A CA  1 
ATOM   5751 C  C   . LEU A 1 929 ? 170.168 147.220 158.495 1.00 33.89  ? 919  LEU A C   1 
ATOM   5752 O  O   . LEU A 1 929 ? 170.508 146.594 157.482 1.00 33.89  ? 919  LEU A O   1 
ATOM   5753 C  CB  . LEU A 1 929 ? 169.065 146.053 160.422 1.00 33.89  ? 919  LEU A CB  1 
ATOM   5754 C  CG  . LEU A 1 929 ? 169.136 144.677 161.081 1.00 33.89  ? 919  LEU A CG  1 
ATOM   5755 C  CD1 . LEU A 1 929 ? 167.748 144.195 161.457 1.00 33.89  ? 919  LEU A CD1 1 
ATOM   5756 C  CD2 . LEU A 1 929 ? 169.810 143.687 160.154 1.00 33.89  ? 919  LEU A CD2 1 
ATOM   5757 N  N   . TRP A 1 930 ? 169.618 148.436 158.431 1.00 27.77  ? 920  TRP A N   1 
ATOM   5758 C  CA  . TRP A 1 930 ? 169.423 149.081 157.133 1.00 27.77  ? 920  TRP A CA  1 
ATOM   5759 C  C   . TRP A 1 930 ? 170.755 149.390 156.458 1.00 27.77  ? 920  TRP A C   1 
ATOM   5760 O  O   . TRP A 1 930 ? 170.894 149.220 155.237 1.00 27.77  ? 920  TRP A O   1 
ATOM   5761 C  CB  . TRP A 1 930 ? 168.604 150.360 157.285 1.00 27.77  ? 920  TRP A CB  1 
ATOM   5762 C  CG  . TRP A 1 930 ? 168.411 151.071 155.984 1.00 27.77  ? 920  TRP A CG  1 
ATOM   5763 C  CD1 . TRP A 1 930 ? 167.741 150.605 154.893 1.00 27.77  ? 920  TRP A CD1 1 
ATOM   5764 C  CD2 . TRP A 1 930 ? 168.904 152.367 155.628 1.00 27.77  ? 920  TRP A CD2 1 
ATOM   5765 N  NE1 . TRP A 1 930 ? 167.781 151.532 153.882 1.00 27.77  ? 920  TRP A NE1 1 
ATOM   5766 C  CE2 . TRP A 1 930 ? 168.489 152.623 154.308 1.00 27.77  ? 920  TRP A CE2 1 
ATOM   5767 C  CE3 . TRP A 1 930 ? 169.652 153.337 156.298 1.00 27.77  ? 920  TRP A CE3 1 
ATOM   5768 C  CZ2 . TRP A 1 930 ? 168.797 153.807 153.646 1.00 27.77  ? 920  TRP A CZ2 1 
ATOM   5769 C  CZ3 . TRP A 1 930 ? 169.957 154.512 155.638 1.00 27.77  ? 920  TRP A CZ3 1 
ATOM   5770 C  CH2 . TRP A 1 930 ? 169.530 154.736 154.327 1.00 27.77  ? 920  TRP A CH2 1 
ATOM   5771 N  N   . LEU A 1 931 ? 171.741 149.851 157.235 1.00 31.80  ? 921  LEU A N   1 
ATOM   5772 C  CA  . LEU A 1 931 ? 173.060 150.130 156.676 1.00 31.80  ? 921  LEU A CA  1 
ATOM   5773 C  C   . LEU A 1 931 ? 173.699 148.865 156.122 1.00 31.80  ? 921  LEU A C   1 
ATOM   5774 O  O   . LEU A 1 931 ? 174.273 148.879 155.026 1.00 31.80  ? 921  LEU A O   1 
ATOM   5775 C  CB  . LEU A 1 931 ? 173.957 150.755 157.742 1.00 31.80  ? 921  LEU A CB  1 
ATOM   5776 C  CG  . LEU A 1 931 ? 173.747 152.238 158.044 1.00 31.80  ? 921  LEU A CG  1 
ATOM   5777 C  CD1 . LEU A 1 931 ? 174.749 152.713 159.081 1.00 31.80  ? 921  LEU A CD1 1 
ATOM   5778 C  CD2 . LEU A 1 931 ? 173.859 153.063 156.777 1.00 31.80  ? 921  LEU A CD2 1 
ATOM   5779 N  N   . LEU A 1 932 ? 173.597 147.759 156.862 1.00 36.27  ? 922  LEU A N   1 
ATOM   5780 C  CA  . LEU A 1 932 ? 174.139 146.488 156.394 1.00 36.27  ? 922  LEU A CA  1 
ATOM   5781 C  C   . LEU A 1 932 ? 173.447 146.032 155.116 1.00 36.27  ? 922  LEU A C   1 
ATOM   5782 O  O   . LEU A 1 932 ? 174.103 145.553 154.180 1.00 36.27  ? 922  LEU A O   1 
ATOM   5783 C  CB  . LEU A 1 932 ? 174.001 145.430 157.487 1.00 36.27  ? 922  LEU A CB  1 
ATOM   5784 C  CG  . LEU A 1 932 ? 175.010 144.288 157.412 1.00 36.27  ? 922  LEU A CG  1 
ATOM   5785 C  CD1 . LEU A 1 932 ? 176.383 144.779 157.834 1.00 36.27  ? 922  LEU A CD1 1 
ATOM   5786 C  CD2 . LEU A 1 932 ? 174.560 143.129 158.277 1.00 36.27  ? 922  LEU A CD2 1 
ATOM   5787 N  N   . TYR A 1 933 ? 172.117 146.173 155.063 1.00 28.75  ? 923  TYR A N   1 
ATOM   5788 C  CA  . TYR A 1 933 ? 171.373 145.802 153.862 1.00 28.75  ? 923  TYR A CA  1 
ATOM   5789 C  C   . TYR A 1 933 ? 171.856 146.577 152.647 1.00 28.75  ? 923  TYR A C   1 
ATOM   5790 O  O   . TYR A 1 933 ? 172.171 145.986 151.606 1.00 28.75  ? 923  TYR A O   1 
ATOM   5791 C  CB  . TYR A 1 933 ? 169.875 146.034 154.060 1.00 28.75  ? 923  TYR A CB  1 
ATOM   5792 C  CG  . TYR A 1 933 ? 169.094 145.914 152.770 1.00 28.75  ? 923  TYR A CG  1 
ATOM   5793 C  CD1 . TYR A 1 933 ? 168.730 144.674 152.274 1.00 28.75  ? 923  TYR A CD1 1 
ATOM   5794 C  CD2 . TYR A 1 933 ? 168.725 147.041 152.044 1.00 28.75  ? 923  TYR A CD2 1 
ATOM   5795 C  CE1 . TYR A 1 933 ? 168.028 144.556 151.096 1.00 28.75  ? 923  TYR A CE1 1 
ATOM   5796 C  CE2 . TYR A 1 933 ? 168.031 146.930 150.862 1.00 28.75  ? 923  TYR A CE2 1 
ATOM   5797 C  CZ  . TYR A 1 933 ? 167.679 145.687 150.397 1.00 28.75  ? 923  TYR A CZ  1 
ATOM   5798 O  OH  . TYR A 1 933 ? 166.978 145.574 149.223 1.00 28.75  ? 923  TYR A OH  1 
ATOM   5799 N  N   . ILE A 1 934 ? 171.899 147.909 152.752 1.00 34.58  ? 924  ILE A N   1 
ATOM   5800 C  CA  . ILE A 1 934 ? 172.256 148.700 151.578 1.00 34.58  ? 924  ILE A CA  1 
ATOM   5801 C  C   . ILE A 1 934 ? 173.713 148.472 151.196 1.00 34.58  ? 924  ILE A C   1 
ATOM   5802 O  O   . ILE A 1 934 ? 174.042 148.423 150.004 1.00 34.58  ? 924  ILE A O   1 
ATOM   5803 C  CB  . ILE A 1 934 ? 171.932 150.193 151.785 1.00 34.58  ? 924  ILE A CB  1 
ATOM   5804 C  CG1 . ILE A 1 934 ? 172.775 150.811 152.897 1.00 34.58  ? 924  ILE A CG1 1 
ATOM   5805 C  CG2 . ILE A 1 934 ? 170.457 150.369 152.086 1.00 34.58  ? 924  ILE A CG2 1 
ATOM   5806 C  CD1 . ILE A 1 934 ? 172.744 152.318 152.906 1.00 34.58  ? 924  ILE A CD1 1 
ATOM   5807 N  N   . PHE A 1 935 ? 174.598 148.275 152.181 1.00 41.36  ? 925  PHE A N   1 
ATOM   5808 C  CA  . PHE A 1 935 ? 176.006 148.034 151.884 1.00 41.36  ? 925  PHE A CA  1 
ATOM   5809 C  C   . PHE A 1 935 ? 176.195 146.719 151.139 1.00 41.36  ? 925  PHE A C   1 
ATOM   5810 O  O   . PHE A 1 935 ? 176.887 146.669 150.115 1.00 41.36  ? 925  PHE A O   1 
ATOM   5811 C  CB  . PHE A 1 935 ? 176.811 148.049 153.184 1.00 41.36  ? 925  PHE A CB  1 
ATOM   5812 C  CG  . PHE A 1 935 ? 178.290 147.897 152.990 1.00 41.36  ? 925  PHE A CG  1 
ATOM   5813 C  CD1 . PHE A 1 935 ? 179.039 148.923 152.441 1.00 41.36  ? 925  PHE A CD1 1 
ATOM   5814 C  CD2 . PHE A 1 935 ? 178.936 146.736 153.381 1.00 41.36  ? 925  PHE A CD2 1 
ATOM   5815 C  CE1 . PHE A 1 935 ? 180.403 148.789 152.270 1.00 41.36  ? 925  PHE A CE1 1 
ATOM   5816 C  CE2 . PHE A 1 935 ? 180.299 146.595 153.214 1.00 41.36  ? 925  PHE A CE2 1 
ATOM   5817 C  CZ  . PHE A 1 935 ? 181.034 147.624 152.657 1.00 41.36  ? 925  PHE A CZ  1 
ATOM   5818 N  N   . PHE A 1 936 ? 175.558 145.646 151.618 1.00 41.72  ? 926  PHE A N   1 
ATOM   5819 C  CA  . PHE A 1 936 ? 175.724 144.351 150.966 1.00 41.72  ? 926  PHE A CA  1 
ATOM   5820 C  C   . PHE A 1 936 ? 175.054 144.321 149.597 1.00 41.72  ? 926  PHE A C   1 
ATOM   5821 O  O   . PHE A 1 936 ? 175.590 143.723 148.655 1.00 41.72  ? 926  PHE A O   1 
ATOM   5822 C  CB  . PHE A 1 936 ? 175.186 143.238 151.862 1.00 41.72  ? 926  PHE A CB  1 
ATOM   5823 C  CG  . PHE A 1 936 ? 176.154 142.792 152.921 1.00 41.72  ? 926  PHE A CG  1 
ATOM   5824 C  CD1 . PHE A 1 936 ? 177.372 143.435 153.083 1.00 41.72  ? 926  PHE A CD1 1 
ATOM   5825 C  CD2 . PHE A 1 936 ? 175.848 141.728 153.753 1.00 41.72  ? 926  PHE A CD2 1 
ATOM   5826 C  CE1 . PHE A 1 936 ? 178.263 143.028 154.055 1.00 41.72  ? 926  PHE A CE1 1 
ATOM   5827 C  CE2 . PHE A 1 936 ? 176.736 141.315 154.728 1.00 41.72  ? 926  PHE A CE2 1 
ATOM   5828 C  CZ  . PHE A 1 936 ? 177.945 141.966 154.878 1.00 41.72  ? 926  PHE A CZ  1 
ATOM   5829 N  N   . SER A 1 937 ? 173.889 144.964 149.458 1.00 37.38  ? 927  SER A N   1 
ATOM   5830 C  CA  . SER A 1 937 ? 173.232 145.006 148.155 1.00 37.38  ? 927  SER A CA  1 
ATOM   5831 C  C   . SER A 1 937 ? 174.057 145.791 147.144 1.00 37.38  ? 927  SER A C   1 
ATOM   5832 O  O   . SER A 1 937 ? 174.204 145.368 145.990 1.00 37.38  ? 927  SER A O   1 
ATOM   5833 C  CB  . SER A 1 937 ? 171.836 145.607 148.285 1.00 37.38  ? 927  SER A CB  1 
ATOM   5834 O  OG  . SER A 1 937 ? 171.148 145.545 147.048 1.00 37.38  ? 927  SER A OG  1 
ATOM   5835 N  N   . SER A 1 938 ? 174.620 146.931 147.562 1.00 40.74  ? 928  SER A N   1 
ATOM   5836 C  CA  . SER A 1 938 ? 175.449 147.719 146.658 1.00 40.74  ? 928  SER A CA  1 
ATOM   5837 C  C   . SER A 1 938 ? 176.737 146.987 146.306 1.00 40.74  ? 928  SER A C   1 
ATOM   5838 O  O   . SER A 1 938 ? 177.245 147.123 145.187 1.00 40.74  ? 928  SER A O   1 
ATOM   5839 C  CB  . SER A 1 938 ? 175.755 149.079 147.280 1.00 40.74  ? 928  SER A CB  1 
ATOM   5840 O  OG  . SER A 1 938 ? 174.573 149.846 147.425 1.00 40.74  ? 928  SER A OG  1 
ATOM   5841 N  N   . LEU A 1 939 ? 177.286 146.210 147.243 1.00 45.78  ? 929  LEU A N   1 
ATOM   5842 C  CA  . LEU A 1 939 ? 178.494 145.453 146.931 1.00 45.78  ? 929  LEU A CA  1 
ATOM   5843 C  C   . LEU A 1 939 ? 178.204 144.300 145.980 1.00 45.78  ? 929  LEU A C   1 
ATOM   5844 O  O   . LEU A 1 939 ? 179.032 143.979 145.121 1.00 45.78  ? 929  LEU A O   1 
ATOM   5845 C  CB  . LEU A 1 939 ? 179.153 144.941 148.210 1.00 45.78  ? 929  LEU A CB  1 
ATOM   5846 C  CG  . LEU A 1 939 ? 179.948 145.961 149.030 1.00 45.78  ? 929  LEU A CG  1 
ATOM   5847 C  CD1 . LEU A 1 939 ? 180.916 145.243 149.954 1.00 45.78  ? 929  LEU A CD1 1 
ATOM   5848 C  CD2 . LEU A 1 939 ? 180.688 146.943 148.132 1.00 45.78  ? 929  LEU A CD2 1 
ATOM   5849 N  N   . GLU A 1 940 ? 177.042 143.656 146.114 1.00 45.93  ? 930  GLU A N   1 
ATOM   5850 C  CA  . GLU A 1 940 ? 176.739 142.553 145.207 1.00 45.93  ? 930  GLU A CA  1 
ATOM   5851 C  C   . GLU A 1 940 ? 176.335 143.073 143.834 1.00 45.93  ? 930  GLU A C   1 
ATOM   5852 O  O   . GLU A 1 940 ? 176.531 142.376 142.831 1.00 45.93  ? 930  GLU A O   1 
ATOM   5853 C  CB  . GLU A 1 940 ? 175.695 141.620 145.860 1.00 45.93  ? 930  GLU A CB  1 
ATOM   5854 C  CG  . GLU A 1 940 ? 175.010 140.457 145.055 1.00 45.93  ? 930  GLU A CG  1 
ATOM   5855 C  CD  . GLU A 1 940 ? 174.145 140.813 143.844 1.00 45.93  ? 930  GLU A CD  1 
ATOM   5856 O  OE1 . GLU A 1 940 ? 173.728 141.977 143.678 1.00 45.93  ? 930  GLU A OE1 1 
ATOM   5857 O  OE2 . GLU A 1 940 ? 173.888 139.899 143.033 1.00 45.93  ? 930  GLU A OE2 1 
ATOM   5858 N  N   . ALA A 1 941 ? 175.774 144.285 143.763 1.00 47.61  ? 931  ALA A N   1 
ATOM   5859 C  CA  . ALA A 1 941 ? 175.426 144.859 142.466 1.00 47.61  ? 931  ALA A CA  1 
ATOM   5860 C  C   . ALA A 1 941 ? 176.657 145.094 141.601 1.00 47.61  ? 931  ALA A C   1 
ATOM   5861 O  O   . ALA A 1 941 ? 176.557 145.109 140.370 1.00 47.61  ? 931  ALA A O   1 
ATOM   5862 C  CB  . ALA A 1 941 ? 174.658 146.166 142.657 1.00 47.61  ? 931  ALA A CB  1 
ATOM   5863 N  N   . TYR A 1 942 ? 177.819 145.281 142.222 1.00 53.75  ? 932  TYR A N   1 
ATOM   5864 C  CA  . TYR A 1 942 ? 179.080 145.428 141.511 1.00 53.75  ? 932  TYR A CA  1 
ATOM   5865 C  C   . TYR A 1 942 ? 179.838 144.113 141.380 1.00 53.75  ? 932  TYR A C   1 
ATOM   5866 O  O   . TYR A 1 942 ? 181.042 144.134 141.101 1.00 53.75  ? 932  TYR A O   1 
ATOM   5867 C  CB  . TYR A 1 942 ? 179.957 146.472 142.207 1.00 53.75  ? 932  TYR A CB  1 
ATOM   5868 C  CG  . TYR A 1 942 ? 179.698 147.890 141.749 1.00 53.75  ? 932  TYR A CG  1 
ATOM   5869 C  CD1 . TYR A 1 942 ? 178.569 148.205 141.005 1.00 53.75  ? 932  TYR A CD1 1 
ATOM   5870 C  CD2 . TYR A 1 942 ? 180.583 148.913 142.061 1.00 53.75  ? 932  TYR A CD2 1 
ATOM   5871 C  CE1 . TYR A 1 942 ? 178.328 149.496 140.583 1.00 53.75  ? 932  TYR A CE1 1 
ATOM   5872 C  CE2 . TYR A 1 942 ? 180.350 150.210 141.643 1.00 53.75  ? 932  TYR A CE2 1 
ATOM   5873 C  CZ  . TYR A 1 942 ? 179.221 150.494 140.905 1.00 53.75  ? 932  TYR A CZ  1 
ATOM   5874 O  OH  . TYR A 1 942 ? 178.987 151.783 140.488 1.00 53.75  ? 932  TYR A OH  1 
ATOM   5875 N  N   . CYS A 1 943 ? 179.166 142.982 141.613 1.00 59.32  ? 933  CYS A N   1 
ATOM   5876 C  CA  . CYS A 1 943 ? 179.666 141.616 141.446 1.00 59.32  ? 933  CYS A CA  1 
ATOM   5877 C  C   . CYS A 1 943 ? 180.772 141.259 142.433 1.00 59.32  ? 933  CYS A C   1 
ATOM   5878 O  O   . CYS A 1 943 ? 181.425 140.221 142.273 1.00 59.32  ? 933  CYS A O   1 
ATOM   5879 C  CB  . CYS A 1 943 ? 180.143 141.355 140.009 1.00 59.32  ? 933  CYS A CB  1 
ATOM   5880 S  SG  . CYS A 1 943 ? 180.155 139.618 139.491 1.00 59.32  ? 933  CYS A SG  1 
ATOM   5881 N  N   . HIS A 1 944 ? 181.008 142.087 143.454 1.00 65.66  ? 934  HIS A N   1 
ATOM   5882 C  CA  . HIS A 1 944 ? 181.977 141.723 144.483 1.00 65.66  ? 934  HIS A CA  1 
ATOM   5883 C  C   . HIS A 1 944 ? 181.478 140.553 145.322 1.00 65.66  ? 934  HIS A C   1 
ATOM   5884 O  O   . HIS A 1 944 ? 182.267 139.680 145.705 1.00 65.66  ? 934  HIS A O   1 
ATOM   5885 C  CB  . HIS A 1 944 ? 182.283 142.929 145.369 1.00 65.66  ? 934  HIS A CB  1 
ATOM   5886 C  CG  . HIS A 1 944 ? 183.404 143.782 144.863 1.00 65.66  ? 934  HIS A CG  1 
ATOM   5887 N  ND1 . HIS A 1 944 ? 184.729 143.475 145.081 1.00 65.66  ? 934  HIS A ND1 1 
ATOM   5888 C  CD2 . HIS A 1 944 ? 183.397 144.931 144.147 1.00 65.66  ? 934  HIS A CD2 1 
ATOM   5889 C  CE1 . HIS A 1 944 ? 185.490 144.399 144.523 1.00 65.66  ? 934  HIS A CE1 1 
ATOM   5890 N  NE2 . HIS A 1 944 ? 184.707 145.294 143.950 1.00 65.66  ? 934  HIS A NE2 1 
ATOM   5891 N  N   . ILE A 1 945 ? 180.177 140.526 145.613 1.00 66.89  ? 935  ILE A N   1 
ATOM   5892 C  CA  . ILE A 1 945 ? 179.522 139.491 146.419 1.00 66.89  ? 935  ILE A CA  1 
ATOM   5893 C  C   . ILE A 1 945 ? 180.173 139.323 147.790 1.00 66.89  ? 935  ILE A C   1 
ATOM   5894 O  O   . ILE A 1 945 ? 179.857 140.053 148.729 1.00 66.89  ? 935  ILE A O   1 
ATOM   5895 C  CB  . ILE A 1 945 ? 179.504 138.157 145.671 1.00 66.89  ? 935  ILE A CB  1 
HETATM 5896 CA CA  . CA  B 2 .   ? 158.518 132.627 135.809 1.00 48.71  ? 1001 CA  A CA  1 
HETATM 5897 C  C1  . PIO C 3 .   ? 142.342 140.473 169.693 1.00 114.01 ? 1002 PIO A C1  1 
HETATM 5898 O  O1  . PIO C 3 .   ? 142.772 141.129 168.481 1.00 114.01 ? 1002 PIO A O1  1 
HETATM 5899 P  P1  . PIO C 3 .   ? 143.101 140.146 167.238 1.00 114.01 ? 1002 PIO A P1  1 
HETATM 5900 C  C2  . PIO C 3 .   ? 140.883 140.816 169.987 1.00 114.01 ? 1002 PIO A C2  1 
HETATM 5901 O  O2  . PIO C 3 .   ? 140.199 141.133 168.780 1.00 114.01 ? 1002 PIO A O2  1 
HETATM 5902 C  C3  . PIO C 3 .   ? 140.742 141.968 170.979 1.00 114.01 ? 1002 PIO A C3  1 
HETATM 5903 O  O3  . PIO C 3 .   ? 141.258 143.182 170.443 1.00 114.01 ? 1002 PIO A O3  1 
HETATM 5904 C  C4  . PIO C 3 .   ? 141.396 141.616 172.309 1.00 114.01 ? 1002 PIO A C4  1 
HETATM 5905 O  O4  . PIO C 3 .   ? 140.402 141.084 173.210 1.00 114.01 ? 1002 PIO A O4  1 
HETATM 5906 P  P4  . PIO C 3 .   ? 139.302 142.023 173.954 1.00 114.01 ? 1002 PIO A P4  1 
HETATM 5907 C  C5  . PIO C 3 .   ? 142.498 140.589 172.128 1.00 114.01 ? 1002 PIO A C5  1 
HETATM 5908 O  O5  . PIO C 3 .   ? 143.391 140.610 173.266 1.00 114.01 ? 1002 PIO A O5  1 
HETATM 5909 P  P5  . PIO C 3 .   ? 144.479 141.734 173.719 1.00 114.01 ? 1002 PIO A P5  1 
HETATM 5910 C  C6  . PIO C 3 .   ? 143.267 140.847 170.843 1.00 114.01 ? 1002 PIO A C6  1 
HETATM 5911 O  O6  . PIO C 3 .   ? 144.447 140.055 170.791 1.00 114.01 ? 1002 PIO A O6  1 
HETATM 5912 O  O11 . PIO C 3 .   ? 144.327 140.549 166.512 1.00 114.01 ? 1002 PIO A O11 1 
HETATM 5913 O  O12 . PIO C 3 .   ? 142.993 138.746 167.699 1.00 114.01 ? 1002 PIO A O12 1 
HETATM 5914 O  O13 . PIO C 3 .   ? 141.855 140.428 166.284 1.00 114.01 ? 1002 PIO A O13 1 
HETATM 5915 C  C1A . PIO C 3 .   ? 141.292 137.580 165.171 1.00 114.01 ? 1002 PIO A C1A 1 
HETATM 5916 O  O1A . PIO C 3 .   ? 142.488 137.595 165.056 1.00 114.01 ? 1002 PIO A O1A 1 
HETATM 5917 C  C1B . PIO C 3 .   ? 142.565 137.881 161.563 1.00 114.01 ? 1002 PIO A C1B 1 
HETATM 5918 O  O1B . PIO C 3 .   ? 143.213 138.691 160.957 1.00 114.01 ? 1002 PIO A O1B 1 
HETATM 5919 C  C1C . PIO C 3 .   ? 142.102 140.438 164.863 1.00 114.01 ? 1002 PIO A C1C 1 
HETATM 5920 C  C2A . PIO C 3 .   ? 140.526 136.439 165.769 1.00 114.01 ? 1002 PIO A C2A 1 
HETATM 5921 C  C2B . PIO C 3 .   ? 142.749 136.394 161.489 1.00 114.01 ? 1002 PIO A C2B 1 
HETATM 5922 C  C2C . PIO C 3 .   ? 140.960 139.786 164.101 1.00 114.01 ? 1002 PIO A C2C 1 
HETATM 5923 O  O2C . PIO C 3 .   ? 140.456 138.524 164.676 1.00 114.01 ? 1002 PIO A O2C 1 
HETATM 5924 C  C3A . PIO C 3 .   ? 140.649 135.176 164.929 1.00 114.01 ? 1002 PIO A C3A 1 
HETATM 5925 C  C3B . PIO C 3 .   ? 142.315 135.773 160.171 1.00 114.01 ? 1002 PIO A C3B 1 
HETATM 5926 C  C3C . PIO C 3 .   ? 141.314 139.597 162.634 1.00 114.01 ? 1002 PIO A C3C 1 
HETATM 5927 O  O3C . PIO C 3 .   ? 141.573 138.195 162.395 1.00 114.01 ? 1002 PIO A O3C 1 
HETATM 5928 O  O41 . PIO C 3 .   ? 140.021 143.320 174.259 1.00 114.01 ? 1002 PIO A O41 1 
HETATM 5929 O  O42 . PIO C 3 .   ? 138.913 141.256 175.198 1.00 114.01 ? 1002 PIO A O42 1 
HETATM 5930 O  O43 . PIO C 3 .   ? 138.149 142.208 172.989 1.00 114.01 ? 1002 PIO A O43 1 
HETATM 5931 C  C4A . PIO C 3 .   ? 140.039 133.953 165.592 1.00 114.01 ? 1002 PIO A C4A 1 
HETATM 5932 C  C4B . PIO C 3 .   ? 142.396 134.254 160.202 1.00 114.01 ? 1002 PIO A C4B 1 
HETATM 5933 O  O51 . PIO C 3 .   ? 144.432 141.704 175.233 1.00 114.01 ? 1002 PIO A O51 1 
HETATM 5934 O  O52 . PIO C 3 .   ? 144.048 143.073 173.156 1.00 114.01 ? 1002 PIO A O52 1 
HETATM 5935 O  O53 . PIO C 3 .   ? 145.802 141.259 173.162 1.00 114.01 ? 1002 PIO A O53 1 
HETATM 5936 C  C5A . PIO C 3 .   ? 140.432 132.649 164.915 1.00 114.01 ? 1002 PIO A C5A 1 
HETATM 5937 C  C5B . PIO C 3 .   ? 142.800 133.625 158.879 1.00 114.01 ? 1002 PIO A C5B 1 
HETATM 5938 C  C6A . PIO C 3 .   ? 141.935 132.421 164.872 1.00 114.01 ? 1002 PIO A C6A 1 
HETATM 5939 C  C6B . PIO C 3 .   ? 144.205 134.000 158.433 1.00 114.01 ? 1002 PIO A C6B 1 
HETATM 5940 C  C7A . PIO C 3 .   ? 142.350 131.135 164.179 1.00 114.01 ? 1002 PIO A C7A 1 
HETATM 5941 C  C7B . PIO C 3 .   ? 144.621 133.390 157.107 1.00 114.01 ? 1002 PIO A C7B 1 
HETATM 5942 C  C8A . PIO C 3 .   ? 141.930 131.085 162.726 1.00 114.01 ? 1002 PIO A C8A 1 
HETATM 5943 C  C8B . PIO C 3 .   ? 146.010 133.806 156.677 1.00 114.01 ? 1002 PIO A C8B 1 
HETATM 5944 CA CA  . CA  D 2 .   ? 106.346 130.360 215.828 1.00 40.75  ? 1003 CA  A CA  1 
HETATM 5945 CA CA  . CA  E 2 .   ? 110.319 130.894 214.103 1.00 19.44  ? 1004 CA  A CA  1 
HETATM 5946 CA CA  . CA  F 2 .   ? 114.736 131.840 209.056 1.00 27.59  ? 1005 CA  A CA  1 
HETATM 5947 CA CA  . CA  G 2 .   ? 110.909 131.635 210.537 1.00 27.25  ? 1006 CA  A CA  1 
# 
