data_9IRZ
# 
_entry.id   9IRZ 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9IRZ         pdb_00009irz 10.2210/pdb9irz/pdb 
WWPDB D_1300049473 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
1 'Structure model' 1 0 2025-01-29 
2 'Structure model' 1 1 2025-02-05 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation.pdbx_database_id_PubMed' 
5 2 'Structure model' '_citation.year'                    
6 2 'Structure model' '_citation_author.identifier_ORCID' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9IRZ 
_pdbx_database_status.recvd_initial_deposition_date   2024-07-16 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              ryuse@hanyang.ac.kr 
_pdbx_contact_author.name_first         'Seong Eon' 
_pdbx_contact_author.name_last          Ryu 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-3335-326X 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Kim, M.'   1 0000-0002-2527-4089 
'Kang, R.'  2 ?                   
'Ryu, S.E.' 3 0000-0003-3335-326X 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   CH 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Front Microbiol' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1664-302X 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            15 
_citation.language                  ? 
_citation.page_first                1510655 
_citation.page_last                 1510655 
_citation.title                     
'High-affinity promotor binding of YhaJ mediates a low signal leakage for effective DNT detection.' 
_citation.year                      2024 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.3389/fmicb.2024.1510655 
_citation.pdbx_database_id_PubMed   39831117 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Kim, M.'    1 ? 
primary 'Kang, R.'   2 ? 
primary 'Park, H.M.' 3 ? 
primary 'Cho, E.B.'  4 ? 
primary 'Lee, H.R.'  5 ? 
primary 'Ryu, S.E.'  6 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Probable HTH-type transcriptional regulator YhaJ' 11437.062 2   ? ? ? 'C-terminal His-tag' 
2 non-polymer syn 'PHOSPHATE ION'                                    94.971    3   ? ? ? ?                    
3 non-polymer syn 'CHLORIDE ION'                                     35.453    1   ? ? ? ?                    
4 water       nat water                                              18.015    120 ? ? ? ?                    
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;MAKERALTLEALRVMDAIDRRGSFAAAADELGRVPSALSYTMQKLEEELDVVLFDRSGHRTKFTNVGRMLLERGRVLLEA
ADKLTTDAEALARLEHHHHHH
;
_entity_poly.pdbx_seq_one_letter_code_can   
;MAKERALTLEALRVMDAIDRRGSFAAAADELGRVPSALSYTMQKLEEELDVVLFDRSGHRTKFTNVGRMLLERGRVLLEA
ADKLTTDAEALARLEHHHHHH
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'PHOSPHATE ION' PO4 
3 'CHLORIDE ION'  CL  
4 water           HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   ALA n 
1 3   LYS n 
1 4   GLU n 
1 5   ARG n 
1 6   ALA n 
1 7   LEU n 
1 8   THR n 
1 9   LEU n 
1 10  GLU n 
1 11  ALA n 
1 12  LEU n 
1 13  ARG n 
1 14  VAL n 
1 15  MET n 
1 16  ASP n 
1 17  ALA n 
1 18  ILE n 
1 19  ASP n 
1 20  ARG n 
1 21  ARG n 
1 22  GLY n 
1 23  SER n 
1 24  PHE n 
1 25  ALA n 
1 26  ALA n 
1 27  ALA n 
1 28  ALA n 
1 29  ASP n 
1 30  GLU n 
1 31  LEU n 
1 32  GLY n 
1 33  ARG n 
1 34  VAL n 
1 35  PRO n 
1 36  SER n 
1 37  ALA n 
1 38  LEU n 
1 39  SER n 
1 40  TYR n 
1 41  THR n 
1 42  MET n 
1 43  GLN n 
1 44  LYS n 
1 45  LEU n 
1 46  GLU n 
1 47  GLU n 
1 48  GLU n 
1 49  LEU n 
1 50  ASP n 
1 51  VAL n 
1 52  VAL n 
1 53  LEU n 
1 54  PHE n 
1 55  ASP n 
1 56  ARG n 
1 57  SER n 
1 58  GLY n 
1 59  HIS n 
1 60  ARG n 
1 61  THR n 
1 62  LYS n 
1 63  PHE n 
1 64  THR n 
1 65  ASN n 
1 66  VAL n 
1 67  GLY n 
1 68  ARG n 
1 69  MET n 
1 70  LEU n 
1 71  LEU n 
1 72  GLU n 
1 73  ARG n 
1 74  GLY n 
1 75  ARG n 
1 76  VAL n 
1 77  LEU n 
1 78  LEU n 
1 79  GLU n 
1 80  ALA n 
1 81  ALA n 
1 82  ASP n 
1 83  LYS n 
1 84  LEU n 
1 85  THR n 
1 86  THR n 
1 87  ASP n 
1 88  ALA n 
1 89  GLU n 
1 90  ALA n 
1 91  LEU n 
1 92  ALA n 
1 93  ARG n 
1 94  LEU n 
1 95  GLU n 
1 96  HIS n 
1 97  HIS n 
1 98  HIS n 
1 99  HIS n 
1 100 HIS n 
1 101 HIS n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   101 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 'yhaJ, b3105, JW3076' 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     562 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CL  non-polymer         . 'CHLORIDE ION'  ? 'Cl -1'          35.453  
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PO4 non-polymer         . 'PHOSPHATE ION' ? 'O4 P -3'        94.971  
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?  ?   ?   A . n 
A 1 2   ALA 2   2   2  ALA ALA A . n 
A 1 3   LYS 3   3   3  LYS LYS A . n 
A 1 4   GLU 4   4   4  GLU GLU A . n 
A 1 5   ARG 5   5   5  ARG ARG A . n 
A 1 6   ALA 6   6   6  ALA ALA A . n 
A 1 7   LEU 7   7   7  LEU LEU A . n 
A 1 8   THR 8   8   8  THR THR A . n 
A 1 9   LEU 9   9   9  LEU LEU A . n 
A 1 10  GLU 10  10  10 GLU GLU A . n 
A 1 11  ALA 11  11  11 ALA ALA A . n 
A 1 12  LEU 12  12  12 LEU LEU A . n 
A 1 13  ARG 13  13  13 ARG ARG A . n 
A 1 14  VAL 14  14  14 VAL VAL A . n 
A 1 15  MET 15  15  15 MET MET A . n 
A 1 16  ASP 16  16  16 ASP ASP A . n 
A 1 17  ALA 17  17  17 ALA ALA A . n 
A 1 18  ILE 18  18  18 ILE ILE A . n 
A 1 19  ASP 19  19  19 ASP ASP A . n 
A 1 20  ARG 20  20  20 ARG ARG A . n 
A 1 21  ARG 21  21  21 ARG ARG A . n 
A 1 22  GLY 22  22  22 GLY GLY A . n 
A 1 23  SER 23  23  23 SER SER A . n 
A 1 24  PHE 24  24  24 PHE PHE A . n 
A 1 25  ALA 25  25  25 ALA ALA A . n 
A 1 26  ALA 26  26  26 ALA ALA A . n 
A 1 27  ALA 27  27  27 ALA ALA A . n 
A 1 28  ALA 28  28  28 ALA ALA A . n 
A 1 29  ASP 29  29  29 ASP ASP A . n 
A 1 30  GLU 30  30  30 GLU GLU A . n 
A 1 31  LEU 31  31  31 LEU LEU A . n 
A 1 32  GLY 32  32  32 GLY GLY A . n 
A 1 33  ARG 33  33  33 ARG ARG A . n 
A 1 34  VAL 34  34  34 VAL VAL A . n 
A 1 35  PRO 35  35  35 PRO PRO A . n 
A 1 36  SER 36  36  36 SER SER A . n 
A 1 37  ALA 37  37  37 ALA ALA A . n 
A 1 38  LEU 38  38  38 LEU LEU A . n 
A 1 39  SER 39  39  39 SER SER A . n 
A 1 40  TYR 40  40  40 TYR TYR A . n 
A 1 41  THR 41  41  41 THR THR A . n 
A 1 42  MET 42  42  42 MET MET A . n 
A 1 43  GLN 43  43  43 GLN GLN A . n 
A 1 44  LYS 44  44  44 LYS LYS A . n 
A 1 45  LEU 45  45  45 LEU LEU A . n 
A 1 46  GLU 46  46  46 GLU GLU A . n 
A 1 47  GLU 47  47  47 GLU GLU A . n 
A 1 48  GLU 48  48  48 GLU GLU A . n 
A 1 49  LEU 49  49  49 LEU LEU A . n 
A 1 50  ASP 50  50  50 ASP ASP A . n 
A 1 51  VAL 51  51  51 VAL VAL A . n 
A 1 52  VAL 52  52  52 VAL VAL A . n 
A 1 53  LEU 53  53  53 LEU LEU A . n 
A 1 54  PHE 54  54  54 PHE PHE A . n 
A 1 55  ASP 55  55  55 ASP ASP A . n 
A 1 56  ARG 56  56  56 ARG ARG A . n 
A 1 57  SER 57  57  57 SER SER A . n 
A 1 58  GLY 58  58  ?  ?   ?   A . n 
A 1 59  HIS 59  59  ?  ?   ?   A . n 
A 1 60  ARG 60  60  60 ARG ARG A . n 
A 1 61  THR 61  61  61 THR THR A . n 
A 1 62  LYS 62  62  62 LYS LYS A . n 
A 1 63  PHE 63  63  63 PHE PHE A . n 
A 1 64  THR 64  64  64 THR THR A . n 
A 1 65  ASN 65  65  65 ASN ASN A . n 
A 1 66  VAL 66  66  66 VAL VAL A . n 
A 1 67  GLY 67  67  67 GLY GLY A . n 
A 1 68  ARG 68  68  68 ARG ARG A . n 
A 1 69  MET 69  69  69 MET MET A . n 
A 1 70  LEU 70  70  70 LEU LEU A . n 
A 1 71  LEU 71  71  71 LEU LEU A . n 
A 1 72  GLU 72  72  72 GLU GLU A . n 
A 1 73  ARG 73  73  73 ARG ARG A . n 
A 1 74  GLY 74  74  74 GLY GLY A . n 
A 1 75  ARG 75  75  75 ARG ARG A . n 
A 1 76  VAL 76  76  76 VAL VAL A . n 
A 1 77  LEU 77  77  77 LEU LEU A . n 
A 1 78  LEU 78  78  78 LEU LEU A . n 
A 1 79  GLU 79  79  79 GLU GLU A . n 
A 1 80  ALA 80  80  80 ALA ALA A . n 
A 1 81  ALA 81  81  81 ALA ALA A . n 
A 1 82  ASP 82  82  82 ASP ASP A . n 
A 1 83  LYS 83  83  83 LYS LYS A . n 
A 1 84  LEU 84  84  84 LEU LEU A . n 
A 1 85  THR 85  85  85 THR THR A . n 
A 1 86  THR 86  86  86 THR THR A . n 
A 1 87  ASP 87  87  87 ASP ASP A . n 
A 1 88  ALA 88  88  88 ALA ALA A . n 
A 1 89  GLU 89  89  89 GLU GLU A . n 
A 1 90  ALA 90  90  90 ALA ALA A . n 
A 1 91  LEU 91  91  91 LEU LEU A . n 
A 1 92  ALA 92  92  92 ALA ALA A . n 
A 1 93  ARG 93  93  93 ARG ARG A . n 
A 1 94  LEU 94  94  94 LEU LEU A . n 
A 1 95  GLU 95  95  95 GLU GLU A . n 
A 1 96  HIS 96  96  96 HIS HIS A . n 
A 1 97  HIS 97  97  97 HIS HIS A . n 
A 1 98  HIS 98  98  98 HIS HIS A . n 
A 1 99  HIS 99  99  99 HIS HIS A . n 
A 1 100 HIS 100 100 ?  ?   ?   A . n 
A 1 101 HIS 101 101 ?  ?   ?   A . n 
B 1 1   MET 1   1   ?  ?   ?   B . n 
B 1 2   ALA 2   2   ?  ?   ?   B . n 
B 1 3   LYS 3   3   ?  ?   ?   B . n 
B 1 4   GLU 4   4   ?  ?   ?   B . n 
B 1 5   ARG 5   5   5  ARG ARG B . n 
B 1 6   ALA 6   6   6  ALA ALA B . n 
B 1 7   LEU 7   7   7  LEU LEU B . n 
B 1 8   THR 8   8   8  THR THR B . n 
B 1 9   LEU 9   9   9  LEU LEU B . n 
B 1 10  GLU 10  10  10 GLU GLU B . n 
B 1 11  ALA 11  11  11 ALA ALA B . n 
B 1 12  LEU 12  12  12 LEU LEU B . n 
B 1 13  ARG 13  13  13 ARG ARG B . n 
B 1 14  VAL 14  14  14 VAL VAL B . n 
B 1 15  MET 15  15  15 MET MET B . n 
B 1 16  ASP 16  16  16 ASP ASP B . n 
B 1 17  ALA 17  17  17 ALA ALA B . n 
B 1 18  ILE 18  18  18 ILE ILE B . n 
B 1 19  ASP 19  19  19 ASP ASP B . n 
B 1 20  ARG 20  20  20 ARG ARG B . n 
B 1 21  ARG 21  21  21 ARG ARG B . n 
B 1 22  GLY 22  22  22 GLY GLY B . n 
B 1 23  SER 23  23  23 SER SER B . n 
B 1 24  PHE 24  24  24 PHE PHE B . n 
B 1 25  ALA 25  25  25 ALA ALA B . n 
B 1 26  ALA 26  26  26 ALA ALA B . n 
B 1 27  ALA 27  27  27 ALA ALA B . n 
B 1 28  ALA 28  28  28 ALA ALA B . n 
B 1 29  ASP 29  29  29 ASP ASP B . n 
B 1 30  GLU 30  30  30 GLU GLU B . n 
B 1 31  LEU 31  31  31 LEU LEU B . n 
B 1 32  GLY 32  32  32 GLY GLY B . n 
B 1 33  ARG 33  33  33 ARG ARG B . n 
B 1 34  VAL 34  34  34 VAL VAL B . n 
B 1 35  PRO 35  35  35 PRO PRO B . n 
B 1 36  SER 36  36  36 SER SER B . n 
B 1 37  ALA 37  37  37 ALA ALA B . n 
B 1 38  LEU 38  38  38 LEU LEU B . n 
B 1 39  SER 39  39  39 SER SER B . n 
B 1 40  TYR 40  40  40 TYR TYR B . n 
B 1 41  THR 41  41  41 THR THR B . n 
B 1 42  MET 42  42  42 MET MET B . n 
B 1 43  GLN 43  43  43 GLN GLN B . n 
B 1 44  LYS 44  44  44 LYS LYS B . n 
B 1 45  LEU 45  45  45 LEU LEU B . n 
B 1 46  GLU 46  46  46 GLU GLU B . n 
B 1 47  GLU 47  47  47 GLU GLU B . n 
B 1 48  GLU 48  48  48 GLU GLU B . n 
B 1 49  LEU 49  49  49 LEU LEU B . n 
B 1 50  ASP 50  50  50 ASP ASP B . n 
B 1 51  VAL 51  51  51 VAL VAL B . n 
B 1 52  VAL 52  52  52 VAL VAL B . n 
B 1 53  LEU 53  53  53 LEU LEU B . n 
B 1 54  PHE 54  54  54 PHE PHE B . n 
B 1 55  ASP 55  55  55 ASP ASP B . n 
B 1 56  ARG 56  56  56 ARG ARG B . n 
B 1 57  SER 57  57  57 SER SER B . n 
B 1 58  GLY 58  58  ?  ?   ?   B . n 
B 1 59  HIS 59  59  ?  ?   ?   B . n 
B 1 60  ARG 60  60  60 ARG ARG B . n 
B 1 61  THR 61  61  61 THR THR B . n 
B 1 62  LYS 62  62  62 LYS LYS B . n 
B 1 63  PHE 63  63  63 PHE PHE B . n 
B 1 64  THR 64  64  64 THR THR B . n 
B 1 65  ASN 65  65  65 ASN ASN B . n 
B 1 66  VAL 66  66  66 VAL VAL B . n 
B 1 67  GLY 67  67  67 GLY GLY B . n 
B 1 68  ARG 68  68  68 ARG ARG B . n 
B 1 69  MET 69  69  69 MET MET B . n 
B 1 70  LEU 70  70  70 LEU LEU B . n 
B 1 71  LEU 71  71  71 LEU LEU B . n 
B 1 72  GLU 72  72  72 GLU GLU B . n 
B 1 73  ARG 73  73  73 ARG ARG B . n 
B 1 74  GLY 74  74  74 GLY GLY B . n 
B 1 75  ARG 75  75  75 ARG ARG B . n 
B 1 76  VAL 76  76  76 VAL VAL B . n 
B 1 77  LEU 77  77  77 LEU LEU B . n 
B 1 78  LEU 78  78  78 LEU LEU B . n 
B 1 79  GLU 79  79  79 GLU GLU B . n 
B 1 80  ALA 80  80  80 ALA ALA B . n 
B 1 81  ALA 81  81  81 ALA ALA B . n 
B 1 82  ASP 82  82  82 ASP ASP B . n 
B 1 83  LYS 83  83  83 LYS LYS B . n 
B 1 84  LEU 84  84  84 LEU LEU B . n 
B 1 85  THR 85  85  85 THR THR B . n 
B 1 86  THR 86  86  86 THR THR B . n 
B 1 87  ASP 87  87  87 ASP ASP B . n 
B 1 88  ALA 88  88  88 ALA ALA B . n 
B 1 89  GLU 89  89  89 GLU GLU B . n 
B 1 90  ALA 90  90  90 ALA ALA B . n 
B 1 91  LEU 91  91  91 LEU LEU B . n 
B 1 92  ALA 92  92  92 ALA ALA B . n 
B 1 93  ARG 93  93  93 ARG ARG B . n 
B 1 94  LEU 94  94  94 LEU LEU B . n 
B 1 95  GLU 95  95  95 GLU GLU B . n 
B 1 96  HIS 96  96  ?  ?   ?   B . n 
B 1 97  HIS 97  97  ?  ?   ?   B . n 
B 1 98  HIS 98  98  ?  ?   ?   B . n 
B 1 99  HIS 99  99  ?  ?   ?   B . n 
B 1 100 HIS 100 100 ?  ?   ?   B . n 
B 1 101 HIS 101 101 ?  ?   ?   B . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 PO4 1  201 1   PO4 PO4 A . 
D 2 PO4 1  202 2   PO4 PO4 A . 
E 2 PO4 1  201 3   PO4 PO4 B . 
F 3 CL  1  202 4   CL  CL  B . 
G 4 HOH 1  301 71  HOH HOH A . 
G 4 HOH 2  302 56  HOH HOH A . 
G 4 HOH 3  303 21  HOH HOH A . 
G 4 HOH 4  304 63  HOH HOH A . 
G 4 HOH 5  305 62  HOH HOH A . 
G 4 HOH 6  306 60  HOH HOH A . 
G 4 HOH 7  307 118 HOH HOH A . 
G 4 HOH 8  308 111 HOH HOH A . 
G 4 HOH 9  309 96  HOH HOH A . 
G 4 HOH 10 310 95  HOH HOH A . 
G 4 HOH 11 311 4   HOH HOH A . 
G 4 HOH 12 312 94  HOH HOH A . 
G 4 HOH 13 313 109 HOH HOH A . 
G 4 HOH 14 314 26  HOH HOH A . 
G 4 HOH 15 315 98  HOH HOH A . 
G 4 HOH 16 316 59  HOH HOH A . 
G 4 HOH 17 317 67  HOH HOH A . 
G 4 HOH 18 318 30  HOH HOH A . 
G 4 HOH 19 319 1   HOH HOH A . 
G 4 HOH 20 320 52  HOH HOH A . 
G 4 HOH 21 321 93  HOH HOH A . 
G 4 HOH 22 322 33  HOH HOH A . 
G 4 HOH 23 323 38  HOH HOH A . 
G 4 HOH 24 324 80  HOH HOH A . 
G 4 HOH 25 325 9   HOH HOH A . 
G 4 HOH 26 326 113 HOH HOH A . 
G 4 HOH 27 327 110 HOH HOH A . 
G 4 HOH 28 328 69  HOH HOH A . 
G 4 HOH 29 329 13  HOH HOH A . 
G 4 HOH 30 330 25  HOH HOH A . 
G 4 HOH 31 331 57  HOH HOH A . 
G 4 HOH 32 332 23  HOH HOH A . 
G 4 HOH 33 333 58  HOH HOH A . 
G 4 HOH 34 334 46  HOH HOH A . 
G 4 HOH 35 335 66  HOH HOH A . 
G 4 HOH 36 336 34  HOH HOH A . 
G 4 HOH 37 337 50  HOH HOH A . 
G 4 HOH 38 338 78  HOH HOH A . 
G 4 HOH 39 339 44  HOH HOH A . 
G 4 HOH 40 340 7   HOH HOH A . 
G 4 HOH 41 341 54  HOH HOH A . 
G 4 HOH 42 342 11  HOH HOH A . 
G 4 HOH 43 343 42  HOH HOH A . 
G 4 HOH 44 344 36  HOH HOH A . 
G 4 HOH 45 345 77  HOH HOH A . 
G 4 HOH 46 346 8   HOH HOH A . 
G 4 HOH 47 347 19  HOH HOH A . 
G 4 HOH 48 348 112 HOH HOH A . 
G 4 HOH 49 349 83  HOH HOH A . 
G 4 HOH 50 350 101 HOH HOH A . 
G 4 HOH 51 351 103 HOH HOH A . 
G 4 HOH 52 352 114 HOH HOH A . 
G 4 HOH 53 353 64  HOH HOH A . 
G 4 HOH 54 354 53  HOH HOH A . 
G 4 HOH 55 355 99  HOH HOH A . 
G 4 HOH 56 356 12  HOH HOH A . 
G 4 HOH 57 357 75  HOH HOH A . 
G 4 HOH 58 358 104 HOH HOH A . 
G 4 HOH 59 359 65  HOH HOH A . 
G 4 HOH 60 360 79  HOH HOH A . 
G 4 HOH 61 361 72  HOH HOH A . 
G 4 HOH 62 362 82  HOH HOH A . 
G 4 HOH 63 363 100 HOH HOH A . 
G 4 HOH 64 364 85  HOH HOH A . 
G 4 HOH 65 365 61  HOH HOH A . 
G 4 HOH 66 366 97  HOH HOH A . 
G 4 HOH 67 367 31  HOH HOH A . 
H 4 HOH 1  301 117 HOH HOH B . 
H 4 HOH 2  302 120 HOH HOH B . 
H 4 HOH 3  303 105 HOH HOH B . 
H 4 HOH 4  304 16  HOH HOH B . 
H 4 HOH 5  305 55  HOH HOH B . 
H 4 HOH 6  306 32  HOH HOH B . 
H 4 HOH 7  307 91  HOH HOH B . 
H 4 HOH 8  308 24  HOH HOH B . 
H 4 HOH 9  309 37  HOH HOH B . 
H 4 HOH 10 310 108 HOH HOH B . 
H 4 HOH 11 311 84  HOH HOH B . 
H 4 HOH 12 312 89  HOH HOH B . 
H 4 HOH 13 313 47  HOH HOH B . 
H 4 HOH 14 314 86  HOH HOH B . 
H 4 HOH 15 315 106 HOH HOH B . 
H 4 HOH 16 316 40  HOH HOH B . 
H 4 HOH 17 317 39  HOH HOH B . 
H 4 HOH 18 318 29  HOH HOH B . 
H 4 HOH 19 319 115 HOH HOH B . 
H 4 HOH 20 320 14  HOH HOH B . 
H 4 HOH 21 321 17  HOH HOH B . 
H 4 HOH 22 322 92  HOH HOH B . 
H 4 HOH 23 323 116 HOH HOH B . 
H 4 HOH 24 324 28  HOH HOH B . 
H 4 HOH 25 325 70  HOH HOH B . 
H 4 HOH 26 326 10  HOH HOH B . 
H 4 HOH 27 327 48  HOH HOH B . 
H 4 HOH 28 328 18  HOH HOH B . 
H 4 HOH 29 329 73  HOH HOH B . 
H 4 HOH 30 330 41  HOH HOH B . 
H 4 HOH 31 331 81  HOH HOH B . 
H 4 HOH 32 332 102 HOH HOH B . 
H 4 HOH 33 333 2   HOH HOH B . 
H 4 HOH 34 334 43  HOH HOH B . 
H 4 HOH 35 335 3   HOH HOH B . 
H 4 HOH 36 336 22  HOH HOH B . 
H 4 HOH 37 337 119 HOH HOH B . 
H 4 HOH 38 338 88  HOH HOH B . 
H 4 HOH 39 339 6   HOH HOH B . 
H 4 HOH 40 340 35  HOH HOH B . 
H 4 HOH 41 341 5   HOH HOH B . 
H 4 HOH 42 342 45  HOH HOH B . 
H 4 HOH 43 343 107 HOH HOH B . 
H 4 HOH 44 344 87  HOH HOH B . 
H 4 HOH 45 345 27  HOH HOH B . 
H 4 HOH 46 346 15  HOH HOH B . 
H 4 HOH 47 347 49  HOH HOH B . 
H 4 HOH 48 348 68  HOH HOH B . 
H 4 HOH 49 349 74  HOH HOH B . 
H 4 HOH 50 350 51  HOH HOH B . 
H 4 HOH 51 351 90  HOH HOH B . 
H 4 HOH 52 352 20  HOH HOH B . 
H 4 HOH 53 353 76  HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A ARG 60 ? CG  ? A ARG 60 CG  
2  1 Y 1 A ARG 60 ? CD  ? A ARG 60 CD  
3  1 Y 1 A ARG 60 ? NE  ? A ARG 60 NE  
4  1 Y 1 A ARG 60 ? CZ  ? A ARG 60 CZ  
5  1 Y 1 A ARG 60 ? NH1 ? A ARG 60 NH1 
6  1 Y 1 A ARG 60 ? NH2 ? A ARG 60 NH2 
7  1 Y 1 B ARG 60 ? CG  ? B ARG 60 CG  
8  1 Y 1 B ARG 60 ? CD  ? B ARG 60 CD  
9  1 Y 1 B ARG 60 ? NE  ? B ARG 60 NE  
10 1 Y 1 B ARG 60 ? CZ  ? B ARG 60 CZ  
11 1 Y 1 B ARG 60 ? NH1 ? B ARG 60 NH1 
12 1 Y 1 B ARG 60 ? NH2 ? B ARG 60 NH2 
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.19.2_4158 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? v715        2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? HKL-2000 ? ? ? v715        3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHENIX   ? ? ? 1.19.2_4158 4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9IRZ 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     117.157 
_cell.length_a_esd                 ? 
_cell.length_b                     117.157 
_cell.length_b_esd                 ? 
_cell.length_c                     35.092 
_cell.length_c_esd                 ? 
_cell.volume                       417133.661 
_cell.volume_esd                   ? 
_cell.Z_PDB                        18 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9IRZ 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                146 
_symmetry.space_group_name_Hall            'R 3' 
_symmetry.space_group_name_H-M             'H 3' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9IRZ 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.04 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          39.7 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              8.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '0.1 M Tris-Cl pH 8.5, 2.0 M ammonium phosphate monobasic' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            291 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     CCD 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'ADSC QUANTUM 210' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2022-07-07 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.97933 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'PAL/PLS BEAMLINE 7A (6B, 6C1)' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.97933 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   '7A (6B, 6C1)' 
_diffrn_source.pdbx_synchrotron_site       PAL/PLS 
# 
_reflns.B_iso_Wilson_estimate                          20.97 
_reflns.entry_id                                       9IRZ 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              1.76 
_reflns.d_resolution_low                               33.82 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     17579 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           98.86 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                3.7 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          13.59 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.07136 
_reflns.pdbx_Rpim_I_all                                0.03468 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   0.997 
_reflns.pdbx_CC_star                                   0.999 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.06215 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    1.76 
_reflns_shell.d_res_low                                     1.82 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           4.25 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             1671 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               0.2718 
_reflns_shell.pdbx_Rpim_I_all                               0.1521 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.873 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  0.2234 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               24.53 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9IRZ 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            1.76 
_refine.ls_d_res_low                             33.82 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     17577 
_refine.ls_number_reflns_R_free                  1759 
_refine.ls_number_reflns_R_work                  15818 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    98.87 
_refine.ls_percent_reflns_R_free                 10.01 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.1849 
_refine.ls_R_factor_R_free                       0.2212 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.1809 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          2.27 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1100 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 21.9005 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.2113 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       1.76 
_refine_hist.d_res_low                        33.82 
_refine_hist.number_atoms_solvent             120 
_refine_hist.number_atoms_total               1577 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1441 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         16 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0036 ? 1488 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.6634 ? 2003 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0371 ? 236  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0065 ? 258  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 4.4927 ? 211  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 1.76 1.81  . . 127 1143 94.42  . . . . 0.2236 . . . . . . . . . . . 0.2951 
'X-RAY DIFFRACTION' 1.81 1.86  . . 129 1212 96.96  . . . . 0.2064 . . . . . . . . . . . 0.2723 
'X-RAY DIFFRACTION' 1.86 1.92  . . 131 1198 98.37  . . . . 0.1951 . . . . . . . . . . . 0.2096 
'X-RAY DIFFRACTION' 1.92 1.99  . . 140 1229 98.35  . . . . 0.1943 . . . . . . . . . . . 0.2482 
'X-RAY DIFFRACTION' 1.99 2.07  . . 136 1215 99.41  . . . . 0.1915 . . . . . . . . . . . 0.2503 
'X-RAY DIFFRACTION' 2.07 2.16  . . 132 1233 99.64  . . . . 0.1670 . . . . . . . . . . . 0.2025 
'X-RAY DIFFRACTION' 2.16 2.28  . . 136 1208 99.33  . . . . 0.1695 . . . . . . . . . . . 0.2180 
'X-RAY DIFFRACTION' 2.28 2.42  . . 140 1231 99.78  . . . . 0.1795 . . . . . . . . . . . 0.2085 
'X-RAY DIFFRACTION' 2.42 2.61  . . 137 1218 99.78  . . . . 0.1810 . . . . . . . . . . . 0.2192 
'X-RAY DIFFRACTION' 2.61 2.87  . . 138 1242 99.78  . . . . 0.1932 . . . . . . . . . . . 0.2645 
'X-RAY DIFFRACTION' 2.87 3.28  . . 135 1229 99.93  . . . . 0.1806 . . . . . . . . . . . 0.2241 
'X-RAY DIFFRACTION' 3.29 4.14  . . 137 1229 100.00 . . . . 0.1655 . . . . . . . . . . . 0.2057 
'X-RAY DIFFRACTION' 4.14 33.82 . . 141 1231 99.78  . . . . 0.1811 . . . . . . . . . . . 0.1969 
# 
_struct.entry_id                     9IRZ 
_struct.title                        'Crystal structure of YhaJ DNA-binding domain' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9IRZ 
_struct_keywords.text            'DNA-binding, LTTR, TRANSCRIPTION' 
_struct_keywords.pdbx_keywords   TRANSCRIPTION 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 2 ? 
E N N 2 ? 
F N N 3 ? 
G N N 4 ? 
H N N 4 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    YHAJ_ECOLI 
_struct_ref.pdbx_db_accession          P67660 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;MAKERALTLEALRVMDAIDRRGSFAAAADELGRVPSALSYTMQKLEEELDVVLFDRSGHRTKFTNVGRMLLERGRVLLEA
ADKLTTDAEALAR
;
_struct_ref.pdbx_align_begin           1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9IRZ A 1 ? 93 ? P67660 1 ? 93 ? 1 93 
2 1 9IRZ B 1 ? 93 ? P67660 1 ? 93 ? 1 93 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9IRZ LEU A 94  ? UNP P67660 ? ? 'expression tag' 94  1  
1 9IRZ GLU A 95  ? UNP P67660 ? ? 'expression tag' 95  2  
1 9IRZ HIS A 96  ? UNP P67660 ? ? 'expression tag' 96  3  
1 9IRZ HIS A 97  ? UNP P67660 ? ? 'expression tag' 97  4  
1 9IRZ HIS A 98  ? UNP P67660 ? ? 'expression tag' 98  5  
1 9IRZ HIS A 99  ? UNP P67660 ? ? 'expression tag' 99  6  
1 9IRZ HIS A 100 ? UNP P67660 ? ? 'expression tag' 100 7  
1 9IRZ HIS A 101 ? UNP P67660 ? ? 'expression tag' 101 8  
2 9IRZ LEU B 94  ? UNP P67660 ? ? 'expression tag' 94  9  
2 9IRZ GLU B 95  ? UNP P67660 ? ? 'expression tag' 95  10 
2 9IRZ HIS B 96  ? UNP P67660 ? ? 'expression tag' 96  11 
2 9IRZ HIS B 97  ? UNP P67660 ? ? 'expression tag' 97  12 
2 9IRZ HIS B 98  ? UNP P67660 ? ? 'expression tag' 98  13 
2 9IRZ HIS B 99  ? UNP P67660 ? ? 'expression tag' 99  14 
2 9IRZ HIS B 100 ? UNP P67660 ? ? 'expression tag' 100 15 
2 9IRZ HIS B 101 ? UNP P67660 ? ? 'expression tag' 101 16 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 3690 ? 
1 MORE         -37  ? 
1 'SSA (A^2)'  9940 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 THR A 8  ? GLY A 22 ? THR A 8  GLY A 22 1 ? 15 
HELX_P HELX_P2 AA2 SER A 23 ? GLY A 32 ? SER A 23 GLY A 32 1 ? 10 
HELX_P HELX_P3 AA3 VAL A 34 ? ASP A 50 ? VAL A 34 ASP A 50 1 ? 17 
HELX_P HELX_P4 AA4 THR A 64 ? GLU A 95 ? THR A 64 GLU A 95 1 ? 32 
HELX_P HELX_P5 AA5 THR B 8  ? GLY B 22 ? THR B 8  GLY B 22 1 ? 15 
HELX_P HELX_P6 AA6 SER B 23 ? GLY B 32 ? SER B 23 GLY B 32 1 ? 10 
HELX_P HELX_P7 AA7 VAL B 34 ? ASP B 50 ? VAL B 34 ASP B 50 1 ? 17 
HELX_P HELX_P8 AA8 THR B 64 ? GLU B 95 ? THR B 64 GLU B 95 1 ? 32 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
_struct_sheet.id               AA1 
_struct_sheet.type             ? 
_struct_sheet.number_strands   2 
_struct_sheet.details          ? 
# 
_struct_sheet_order.sheet_id     AA1 
_struct_sheet_order.range_id_1   1 
_struct_sheet_order.range_id_2   2 
_struct_sheet_order.offset       ? 
_struct_sheet_order.sense        anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PHE B 54 ? ASP B 55 ? PHE B 54 ASP B 55 
AA1 2 LYS B 62 ? PHE B 63 ? LYS B 62 PHE B 63 
# 
_pdbx_struct_sheet_hbond.sheet_id                AA1 
_pdbx_struct_sheet_hbond.range_id_1              1 
_pdbx_struct_sheet_hbond.range_id_2              2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id   N 
_pdbx_struct_sheet_hbond.range_1_label_comp_id   ASP 
_pdbx_struct_sheet_hbond.range_1_label_asym_id   B 
_pdbx_struct_sheet_hbond.range_1_label_seq_id    55 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code    ? 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id    N 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id    ASP 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id    B 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id     55 
_pdbx_struct_sheet_hbond.range_2_label_atom_id   O 
_pdbx_struct_sheet_hbond.range_2_label_comp_id   LYS 
_pdbx_struct_sheet_hbond.range_2_label_asym_id   B 
_pdbx_struct_sheet_hbond.range_2_label_seq_id    62 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code    ? 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id    O 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id    LYS 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id    B 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id     62 
# 
_pdbx_entry_details.entry_id                   9IRZ 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z                 
2 -y,x-y,z              
3 -x+y,-x,z             
4 x+1/3,y+2/3,z+2/3     
5 -y+1/3,x-y+2/3,z+2/3  
6 -x+y+1/3,-x+2/3,z+2/3 
7 x+2/3,y+1/3,z+1/3     
8 -y+2/3,x-y+1/3,z+1/3  
9 -x+y+2/3,-x+1/3,z+1/3 
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      B 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       353 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   6.47 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A GLY 58  ? A GLY 58  
3  1 Y 1 A HIS 59  ? A HIS 59  
4  1 Y 1 A HIS 100 ? A HIS 100 
5  1 Y 1 A HIS 101 ? A HIS 101 
6  1 Y 1 B MET 1   ? B MET 1   
7  1 Y 1 B ALA 2   ? B ALA 2   
8  1 Y 1 B LYS 3   ? B LYS 3   
9  1 Y 1 B GLU 4   ? B GLU 4   
10 1 Y 1 B GLY 58  ? B GLY 58  
11 1 Y 1 B HIS 59  ? B HIS 59  
12 1 Y 1 B HIS 96  ? B HIS 96  
13 1 Y 1 B HIS 97  ? B HIS 97  
14 1 Y 1 B HIS 98  ? B HIS 98  
15 1 Y 1 B HIS 99  ? B HIS 99  
16 1 Y 1 B HIS 100 ? B HIS 100 
17 1 Y 1 B HIS 101 ? B HIS 101 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CL  CL   CL N N 74  
GLN N    N  N N 75  
GLN CA   C  N S 76  
GLN C    C  N N 77  
GLN O    O  N N 78  
GLN CB   C  N N 79  
GLN CG   C  N N 80  
GLN CD   C  N N 81  
GLN OE1  O  N N 82  
GLN NE2  N  N N 83  
GLN OXT  O  N N 84  
GLN H    H  N N 85  
GLN H2   H  N N 86  
GLN HA   H  N N 87  
GLN HB2  H  N N 88  
GLN HB3  H  N N 89  
GLN HG2  H  N N 90  
GLN HG3  H  N N 91  
GLN HE21 H  N N 92  
GLN HE22 H  N N 93  
GLN HXT  H  N N 94  
GLU N    N  N N 95  
GLU CA   C  N S 96  
GLU C    C  N N 97  
GLU O    O  N N 98  
GLU CB   C  N N 99  
GLU CG   C  N N 100 
GLU CD   C  N N 101 
GLU OE1  O  N N 102 
GLU OE2  O  N N 103 
GLU OXT  O  N N 104 
GLU H    H  N N 105 
GLU H2   H  N N 106 
GLU HA   H  N N 107 
GLU HB2  H  N N 108 
GLU HB3  H  N N 109 
GLU HG2  H  N N 110 
GLU HG3  H  N N 111 
GLU HE2  H  N N 112 
GLU HXT  H  N N 113 
GLY N    N  N N 114 
GLY CA   C  N N 115 
GLY C    C  N N 116 
GLY O    O  N N 117 
GLY OXT  O  N N 118 
GLY H    H  N N 119 
GLY H2   H  N N 120 
GLY HA2  H  N N 121 
GLY HA3  H  N N 122 
GLY HXT  H  N N 123 
HIS N    N  N N 124 
HIS CA   C  N S 125 
HIS C    C  N N 126 
HIS O    O  N N 127 
HIS CB   C  N N 128 
HIS CG   C  Y N 129 
HIS ND1  N  Y N 130 
HIS CD2  C  Y N 131 
HIS CE1  C  Y N 132 
HIS NE2  N  Y N 133 
HIS OXT  O  N N 134 
HIS H    H  N N 135 
HIS H2   H  N N 136 
HIS HA   H  N N 137 
HIS HB2  H  N N 138 
HIS HB3  H  N N 139 
HIS HD1  H  N N 140 
HIS HD2  H  N N 141 
HIS HE1  H  N N 142 
HIS HE2  H  N N 143 
HIS HXT  H  N N 144 
HOH O    O  N N 145 
HOH H1   H  N N 146 
HOH H2   H  N N 147 
ILE N    N  N N 148 
ILE CA   C  N S 149 
ILE C    C  N N 150 
ILE O    O  N N 151 
ILE CB   C  N S 152 
ILE CG1  C  N N 153 
ILE CG2  C  N N 154 
ILE CD1  C  N N 155 
ILE OXT  O  N N 156 
ILE H    H  N N 157 
ILE H2   H  N N 158 
ILE HA   H  N N 159 
ILE HB   H  N N 160 
ILE HG12 H  N N 161 
ILE HG13 H  N N 162 
ILE HG21 H  N N 163 
ILE HG22 H  N N 164 
ILE HG23 H  N N 165 
ILE HD11 H  N N 166 
ILE HD12 H  N N 167 
ILE HD13 H  N N 168 
ILE HXT  H  N N 169 
LEU N    N  N N 170 
LEU CA   C  N S 171 
LEU C    C  N N 172 
LEU O    O  N N 173 
LEU CB   C  N N 174 
LEU CG   C  N N 175 
LEU CD1  C  N N 176 
LEU CD2  C  N N 177 
LEU OXT  O  N N 178 
LEU H    H  N N 179 
LEU H2   H  N N 180 
LEU HA   H  N N 181 
LEU HB2  H  N N 182 
LEU HB3  H  N N 183 
LEU HG   H  N N 184 
LEU HD11 H  N N 185 
LEU HD12 H  N N 186 
LEU HD13 H  N N 187 
LEU HD21 H  N N 188 
LEU HD22 H  N N 189 
LEU HD23 H  N N 190 
LEU HXT  H  N N 191 
LYS N    N  N N 192 
LYS CA   C  N S 193 
LYS C    C  N N 194 
LYS O    O  N N 195 
LYS CB   C  N N 196 
LYS CG   C  N N 197 
LYS CD   C  N N 198 
LYS CE   C  N N 199 
LYS NZ   N  N N 200 
LYS OXT  O  N N 201 
LYS H    H  N N 202 
LYS H2   H  N N 203 
LYS HA   H  N N 204 
LYS HB2  H  N N 205 
LYS HB3  H  N N 206 
LYS HG2  H  N N 207 
LYS HG3  H  N N 208 
LYS HD2  H  N N 209 
LYS HD3  H  N N 210 
LYS HE2  H  N N 211 
LYS HE3  H  N N 212 
LYS HZ1  H  N N 213 
LYS HZ2  H  N N 214 
LYS HZ3  H  N N 215 
LYS HXT  H  N N 216 
MET N    N  N N 217 
MET CA   C  N S 218 
MET C    C  N N 219 
MET O    O  N N 220 
MET CB   C  N N 221 
MET CG   C  N N 222 
MET SD   S  N N 223 
MET CE   C  N N 224 
MET OXT  O  N N 225 
MET H    H  N N 226 
MET H2   H  N N 227 
MET HA   H  N N 228 
MET HB2  H  N N 229 
MET HB3  H  N N 230 
MET HG2  H  N N 231 
MET HG3  H  N N 232 
MET HE1  H  N N 233 
MET HE2  H  N N 234 
MET HE3  H  N N 235 
MET HXT  H  N N 236 
PHE N    N  N N 237 
PHE CA   C  N S 238 
PHE C    C  N N 239 
PHE O    O  N N 240 
PHE CB   C  N N 241 
PHE CG   C  Y N 242 
PHE CD1  C  Y N 243 
PHE CD2  C  Y N 244 
PHE CE1  C  Y N 245 
PHE CE2  C  Y N 246 
PHE CZ   C  Y N 247 
PHE OXT  O  N N 248 
PHE H    H  N N 249 
PHE H2   H  N N 250 
PHE HA   H  N N 251 
PHE HB2  H  N N 252 
PHE HB3  H  N N 253 
PHE HD1  H  N N 254 
PHE HD2  H  N N 255 
PHE HE1  H  N N 256 
PHE HE2  H  N N 257 
PHE HZ   H  N N 258 
PHE HXT  H  N N 259 
PO4 P    P  N N 260 
PO4 O1   O  N N 261 
PO4 O2   O  N N 262 
PO4 O3   O  N N 263 
PO4 O4   O  N N 264 
PRO N    N  N N 265 
PRO CA   C  N S 266 
PRO C    C  N N 267 
PRO O    O  N N 268 
PRO CB   C  N N 269 
PRO CG   C  N N 270 
PRO CD   C  N N 271 
PRO OXT  O  N N 272 
PRO H    H  N N 273 
PRO HA   H  N N 274 
PRO HB2  H  N N 275 
PRO HB3  H  N N 276 
PRO HG2  H  N N 277 
PRO HG3  H  N N 278 
PRO HD2  H  N N 279 
PRO HD3  H  N N 280 
PRO HXT  H  N N 281 
SER N    N  N N 282 
SER CA   C  N S 283 
SER C    C  N N 284 
SER O    O  N N 285 
SER CB   C  N N 286 
SER OG   O  N N 287 
SER OXT  O  N N 288 
SER H    H  N N 289 
SER H2   H  N N 290 
SER HA   H  N N 291 
SER HB2  H  N N 292 
SER HB3  H  N N 293 
SER HG   H  N N 294 
SER HXT  H  N N 295 
THR N    N  N N 296 
THR CA   C  N S 297 
THR C    C  N N 298 
THR O    O  N N 299 
THR CB   C  N R 300 
THR OG1  O  N N 301 
THR CG2  C  N N 302 
THR OXT  O  N N 303 
THR H    H  N N 304 
THR H2   H  N N 305 
THR HA   H  N N 306 
THR HB   H  N N 307 
THR HG1  H  N N 308 
THR HG21 H  N N 309 
THR HG22 H  N N 310 
THR HG23 H  N N 311 
THR HXT  H  N N 312 
TYR N    N  N N 313 
TYR CA   C  N S 314 
TYR C    C  N N 315 
TYR O    O  N N 316 
TYR CB   C  N N 317 
TYR CG   C  Y N 318 
TYR CD1  C  Y N 319 
TYR CD2  C  Y N 320 
TYR CE1  C  Y N 321 
TYR CE2  C  Y N 322 
TYR CZ   C  Y N 323 
TYR OH   O  N N 324 
TYR OXT  O  N N 325 
TYR H    H  N N 326 
TYR H2   H  N N 327 
TYR HA   H  N N 328 
TYR HB2  H  N N 329 
TYR HB3  H  N N 330 
TYR HD1  H  N N 331 
TYR HD2  H  N N 332 
TYR HE1  H  N N 333 
TYR HE2  H  N N 334 
TYR HH   H  N N 335 
TYR HXT  H  N N 336 
VAL N    N  N N 337 
VAL CA   C  N S 338 
VAL C    C  N N 339 
VAL O    O  N N 340 
VAL CB   C  N N 341 
VAL CG1  C  N N 342 
VAL CG2  C  N N 343 
VAL OXT  O  N N 344 
VAL H    H  N N 345 
VAL H2   H  N N 346 
VAL HA   H  N N 347 
VAL HB   H  N N 348 
VAL HG11 H  N N 349 
VAL HG12 H  N N 350 
VAL HG13 H  N N 351 
VAL HG21 H  N N 352 
VAL HG22 H  N N 353 
VAL HG23 H  N N 354 
VAL HXT  H  N N 355 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
GLN N   CA   sing N N 70  
GLN N   H    sing N N 71  
GLN N   H2   sing N N 72  
GLN CA  C    sing N N 73  
GLN CA  CB   sing N N 74  
GLN CA  HA   sing N N 75  
GLN C   O    doub N N 76  
GLN C   OXT  sing N N 77  
GLN CB  CG   sing N N 78  
GLN CB  HB2  sing N N 79  
GLN CB  HB3  sing N N 80  
GLN CG  CD   sing N N 81  
GLN CG  HG2  sing N N 82  
GLN CG  HG3  sing N N 83  
GLN CD  OE1  doub N N 84  
GLN CD  NE2  sing N N 85  
GLN NE2 HE21 sing N N 86  
GLN NE2 HE22 sing N N 87  
GLN OXT HXT  sing N N 88  
GLU N   CA   sing N N 89  
GLU N   H    sing N N 90  
GLU N   H2   sing N N 91  
GLU CA  C    sing N N 92  
GLU CA  CB   sing N N 93  
GLU CA  HA   sing N N 94  
GLU C   O    doub N N 95  
GLU C   OXT  sing N N 96  
GLU CB  CG   sing N N 97  
GLU CB  HB2  sing N N 98  
GLU CB  HB3  sing N N 99  
GLU CG  CD   sing N N 100 
GLU CG  HG2  sing N N 101 
GLU CG  HG3  sing N N 102 
GLU CD  OE1  doub N N 103 
GLU CD  OE2  sing N N 104 
GLU OE2 HE2  sing N N 105 
GLU OXT HXT  sing N N 106 
GLY N   CA   sing N N 107 
GLY N   H    sing N N 108 
GLY N   H2   sing N N 109 
GLY CA  C    sing N N 110 
GLY CA  HA2  sing N N 111 
GLY CA  HA3  sing N N 112 
GLY C   O    doub N N 113 
GLY C   OXT  sing N N 114 
GLY OXT HXT  sing N N 115 
HIS N   CA   sing N N 116 
HIS N   H    sing N N 117 
HIS N   H2   sing N N 118 
HIS CA  C    sing N N 119 
HIS CA  CB   sing N N 120 
HIS CA  HA   sing N N 121 
HIS C   O    doub N N 122 
HIS C   OXT  sing N N 123 
HIS CB  CG   sing N N 124 
HIS CB  HB2  sing N N 125 
HIS CB  HB3  sing N N 126 
HIS CG  ND1  sing Y N 127 
HIS CG  CD2  doub Y N 128 
HIS ND1 CE1  doub Y N 129 
HIS ND1 HD1  sing N N 130 
HIS CD2 NE2  sing Y N 131 
HIS CD2 HD2  sing N N 132 
HIS CE1 NE2  sing Y N 133 
HIS CE1 HE1  sing N N 134 
HIS NE2 HE2  sing N N 135 
HIS OXT HXT  sing N N 136 
HOH O   H1   sing N N 137 
HOH O   H2   sing N N 138 
ILE N   CA   sing N N 139 
ILE N   H    sing N N 140 
ILE N   H2   sing N N 141 
ILE CA  C    sing N N 142 
ILE CA  CB   sing N N 143 
ILE CA  HA   sing N N 144 
ILE C   O    doub N N 145 
ILE C   OXT  sing N N 146 
ILE CB  CG1  sing N N 147 
ILE CB  CG2  sing N N 148 
ILE CB  HB   sing N N 149 
ILE CG1 CD1  sing N N 150 
ILE CG1 HG12 sing N N 151 
ILE CG1 HG13 sing N N 152 
ILE CG2 HG21 sing N N 153 
ILE CG2 HG22 sing N N 154 
ILE CG2 HG23 sing N N 155 
ILE CD1 HD11 sing N N 156 
ILE CD1 HD12 sing N N 157 
ILE CD1 HD13 sing N N 158 
ILE OXT HXT  sing N N 159 
LEU N   CA   sing N N 160 
LEU N   H    sing N N 161 
LEU N   H2   sing N N 162 
LEU CA  C    sing N N 163 
LEU CA  CB   sing N N 164 
LEU CA  HA   sing N N 165 
LEU C   O    doub N N 166 
LEU C   OXT  sing N N 167 
LEU CB  CG   sing N N 168 
LEU CB  HB2  sing N N 169 
LEU CB  HB3  sing N N 170 
LEU CG  CD1  sing N N 171 
LEU CG  CD2  sing N N 172 
LEU CG  HG   sing N N 173 
LEU CD1 HD11 sing N N 174 
LEU CD1 HD12 sing N N 175 
LEU CD1 HD13 sing N N 176 
LEU CD2 HD21 sing N N 177 
LEU CD2 HD22 sing N N 178 
LEU CD2 HD23 sing N N 179 
LEU OXT HXT  sing N N 180 
LYS N   CA   sing N N 181 
LYS N   H    sing N N 182 
LYS N   H2   sing N N 183 
LYS CA  C    sing N N 184 
LYS CA  CB   sing N N 185 
LYS CA  HA   sing N N 186 
LYS C   O    doub N N 187 
LYS C   OXT  sing N N 188 
LYS CB  CG   sing N N 189 
LYS CB  HB2  sing N N 190 
LYS CB  HB3  sing N N 191 
LYS CG  CD   sing N N 192 
LYS CG  HG2  sing N N 193 
LYS CG  HG3  sing N N 194 
LYS CD  CE   sing N N 195 
LYS CD  HD2  sing N N 196 
LYS CD  HD3  sing N N 197 
LYS CE  NZ   sing N N 198 
LYS CE  HE2  sing N N 199 
LYS CE  HE3  sing N N 200 
LYS NZ  HZ1  sing N N 201 
LYS NZ  HZ2  sing N N 202 
LYS NZ  HZ3  sing N N 203 
LYS OXT HXT  sing N N 204 
MET N   CA   sing N N 205 
MET N   H    sing N N 206 
MET N   H2   sing N N 207 
MET CA  C    sing N N 208 
MET CA  CB   sing N N 209 
MET CA  HA   sing N N 210 
MET C   O    doub N N 211 
MET C   OXT  sing N N 212 
MET CB  CG   sing N N 213 
MET CB  HB2  sing N N 214 
MET CB  HB3  sing N N 215 
MET CG  SD   sing N N 216 
MET CG  HG2  sing N N 217 
MET CG  HG3  sing N N 218 
MET SD  CE   sing N N 219 
MET CE  HE1  sing N N 220 
MET CE  HE2  sing N N 221 
MET CE  HE3  sing N N 222 
MET OXT HXT  sing N N 223 
PHE N   CA   sing N N 224 
PHE N   H    sing N N 225 
PHE N   H2   sing N N 226 
PHE CA  C    sing N N 227 
PHE CA  CB   sing N N 228 
PHE CA  HA   sing N N 229 
PHE C   O    doub N N 230 
PHE C   OXT  sing N N 231 
PHE CB  CG   sing N N 232 
PHE CB  HB2  sing N N 233 
PHE CB  HB3  sing N N 234 
PHE CG  CD1  doub Y N 235 
PHE CG  CD2  sing Y N 236 
PHE CD1 CE1  sing Y N 237 
PHE CD1 HD1  sing N N 238 
PHE CD2 CE2  doub Y N 239 
PHE CD2 HD2  sing N N 240 
PHE CE1 CZ   doub Y N 241 
PHE CE1 HE1  sing N N 242 
PHE CE2 CZ   sing Y N 243 
PHE CE2 HE2  sing N N 244 
PHE CZ  HZ   sing N N 245 
PHE OXT HXT  sing N N 246 
PO4 P   O1   doub N N 247 
PO4 P   O2   sing N N 248 
PO4 P   O3   sing N N 249 
PO4 P   O4   sing N N 250 
PRO N   CA   sing N N 251 
PRO N   CD   sing N N 252 
PRO N   H    sing N N 253 
PRO CA  C    sing N N 254 
PRO CA  CB   sing N N 255 
PRO CA  HA   sing N N 256 
PRO C   O    doub N N 257 
PRO C   OXT  sing N N 258 
PRO CB  CG   sing N N 259 
PRO CB  HB2  sing N N 260 
PRO CB  HB3  sing N N 261 
PRO CG  CD   sing N N 262 
PRO CG  HG2  sing N N 263 
PRO CG  HG3  sing N N 264 
PRO CD  HD2  sing N N 265 
PRO CD  HD3  sing N N 266 
PRO OXT HXT  sing N N 267 
SER N   CA   sing N N 268 
SER N   H    sing N N 269 
SER N   H2   sing N N 270 
SER CA  C    sing N N 271 
SER CA  CB   sing N N 272 
SER CA  HA   sing N N 273 
SER C   O    doub N N 274 
SER C   OXT  sing N N 275 
SER CB  OG   sing N N 276 
SER CB  HB2  sing N N 277 
SER CB  HB3  sing N N 278 
SER OG  HG   sing N N 279 
SER OXT HXT  sing N N 280 
THR N   CA   sing N N 281 
THR N   H    sing N N 282 
THR N   H2   sing N N 283 
THR CA  C    sing N N 284 
THR CA  CB   sing N N 285 
THR CA  HA   sing N N 286 
THR C   O    doub N N 287 
THR C   OXT  sing N N 288 
THR CB  OG1  sing N N 289 
THR CB  CG2  sing N N 290 
THR CB  HB   sing N N 291 
THR OG1 HG1  sing N N 292 
THR CG2 HG21 sing N N 293 
THR CG2 HG22 sing N N 294 
THR CG2 HG23 sing N N 295 
THR OXT HXT  sing N N 296 
TYR N   CA   sing N N 297 
TYR N   H    sing N N 298 
TYR N   H2   sing N N 299 
TYR CA  C    sing N N 300 
TYR CA  CB   sing N N 301 
TYR CA  HA   sing N N 302 
TYR C   O    doub N N 303 
TYR C   OXT  sing N N 304 
TYR CB  CG   sing N N 305 
TYR CB  HB2  sing N N 306 
TYR CB  HB3  sing N N 307 
TYR CG  CD1  doub Y N 308 
TYR CG  CD2  sing Y N 309 
TYR CD1 CE1  sing Y N 310 
TYR CD1 HD1  sing N N 311 
TYR CD2 CE2  doub Y N 312 
TYR CD2 HD2  sing N N 313 
TYR CE1 CZ   doub Y N 314 
TYR CE1 HE1  sing N N 315 
TYR CE2 CZ   sing Y N 316 
TYR CE2 HE2  sing N N 317 
TYR CZ  OH   sing N N 318 
TYR OH  HH   sing N N 319 
TYR OXT HXT  sing N N 320 
VAL N   CA   sing N N 321 
VAL N   H    sing N N 322 
VAL N   H2   sing N N 323 
VAL CA  C    sing N N 324 
VAL CA  CB   sing N N 325 
VAL CA  HA   sing N N 326 
VAL C   O    doub N N 327 
VAL C   OXT  sing N N 328 
VAL CB  CG1  sing N N 329 
VAL CB  CG2  sing N N 330 
VAL CB  HB   sing N N 331 
VAL CG1 HG11 sing N N 332 
VAL CG1 HG12 sing N N 333 
VAL CG1 HG13 sing N N 334 
VAL CG2 HG21 sing N N 335 
VAL CG2 HG22 sing N N 336 
VAL CG2 HG23 sing N N 337 
VAL OXT HXT  sing N N 338 
# 
_pdbx_audit_support.funding_organization   'National Research Foundation (NRF, Korea)' 
_pdbx_audit_support.country                'Korea, Republic Of' 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'in silico model' 
_pdbx_initial_refinement_model.source_name      AlphaFold 
_pdbx_initial_refinement_model.accession_code   AF-P67661-F1 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'R 3 :H' 
_space_group.name_Hall        'R 3' 
_space_group.IT_number        146 
_space_group.crystal_system   trigonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9IRZ 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.008536 
_atom_sites.fract_transf_matrix[1][2]   0.004928 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.009856 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.028497 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
CL ? ? 9.50761 7.44341 ? ? 1.04373  23.83732 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882 3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
P  ? ? 9.51135 5.44231 ? ? 1.42069  35.72801 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ALA A 1 2  ? 13.64435  8.04073  5.13863  1.000 47.96749 ? 2   ALA A N   1 
ATOM   2    C  CA  . ALA A 1 2  ? 13.23937  8.75325  6.34554  1.000 49.81980 ? 2   ALA A CA  1 
ATOM   3    C  C   . ALA A 1 2  ? 13.52494  10.24464 6.22936  1.000 48.41963 ? 2   ALA A C   1 
ATOM   4    O  O   . ALA A 1 2  ? 13.72087  10.91423 7.23883  1.000 48.01135 ? 2   ALA A O   1 
ATOM   5    C  CB  . ALA A 1 2  ? 13.94696  8.17556  7.56425  1.000 43.37521 ? 2   ALA A CB  1 
ATOM   6    N  N   . LYS A 1 3  ? 13.52975  10.77484 5.00238  1.000 45.56979 ? 3   LYS A N   1 
ATOM   7    C  CA  . LYS A 1 3  ? 14.08509  12.10104 4.75213  1.000 50.90309 ? 3   LYS A CA  1 
ATOM   8    C  C   . LYS A 1 3  ? 13.12116  13.05327 4.05383  1.000 55.51493 ? 3   LYS A C   1 
ATOM   9    O  O   . LYS A 1 3  ? 13.54993  13.88147 3.24815  1.000 60.08596 ? 3   LYS A O   1 
ATOM   10   C  CB  . LYS A 1 3  ? 15.36685  12.00617 3.93289  1.000 46.89770 ? 3   LYS A CB  1 
ATOM   11   C  CG  . LYS A 1 3  ? 16.55562  12.61613 4.62294  1.000 41.30627 ? 3   LYS A CG  1 
ATOM   12   C  CD  . LYS A 1 3  ? 17.00064  11.77613 5.77266  1.000 44.30328 ? 3   LYS A CD  1 
ATOM   13   C  CE  . LYS A 1 3  ? 17.83271  10.64542 5.23810  1.000 30.45416 ? 3   LYS A CE  1 
ATOM   14   N  NZ  . LYS A 1 3  ? 17.14773  9.38128  5.53585  1.000 25.77097 ? 3   LYS A NZ  1 
ATOM   15   N  N   . GLU A 1 4  ? 11.82830  12.97863 4.34782  1.000 54.03929 ? 4   GLU A N   1 
ATOM   16   C  CA  . GLU A 1 4  ? 10.92363  14.04677 3.93021  1.000 52.59458 ? 4   GLU A CA  1 
ATOM   17   C  C   . GLU A 1 4  ? 10.84701  15.02494 5.09424  1.000 57.14699 ? 4   GLU A C   1 
ATOM   18   O  O   . GLU A 1 4  ? 10.18549  14.76342 6.10157  1.000 54.38810 ? 4   GLU A O   1 
ATOM   19   C  CB  . GLU A 1 4  ? 9.55564   13.51056 3.53239  1.000 50.75447 ? 4   GLU A CB  1 
ATOM   20   C  CG  . GLU A 1 4  ? 9.06839   14.10788 2.21875  1.000 53.89442 ? 4   GLU A CG  1 
ATOM   21   C  CD  . GLU A 1 4  ? 8.98087   15.62456 2.26684  1.000 46.74899 ? 4   GLU A CD  1 
ATOM   22   O  OE1 . GLU A 1 4  ? 9.54963   16.28404 1.37180  1.000 52.22000 ? 4   GLU A OE1 1 
ATOM   23   O  OE2 . GLU A 1 4  ? 8.35466   16.15948 3.20510  1.000 52.84982 ? 4   GLU A OE2 1 
ATOM   24   N  N   . ARG A 1 5  ? 11.53426  16.15611 4.95615  1.000 50.10254 ? 5   ARG A N   1 
ATOM   25   C  CA  . ARG A 1 5  ? 11.81319  17.03964 6.07778  1.000 47.75297 ? 5   ARG A CA  1 
ATOM   26   C  C   . ARG A 1 5  ? 10.92002  18.27322 6.11881  1.000 38.41275 ? 5   ARG A C   1 
ATOM   27   O  O   . ARG A 1 5  ? 11.06455  19.09113 7.03217  1.000 44.46781 ? 5   ARG A O   1 
ATOM   28   C  CB  . ARG A 1 5  ? 13.28838  17.45677 6.04329  1.000 53.74445 ? 5   ARG A CB  1 
ATOM   29   C  CG  . ARG A 1 5  ? 14.24629  16.26949 6.13000  1.000 54.27720 ? 5   ARG A CG  1 
ATOM   30   C  CD  . ARG A 1 5  ? 15.64323  16.60134 5.61779  1.000 52.25627 ? 5   ARG A CD  1 
ATOM   31   N  NE  . ARG A 1 5  ? 16.62783  16.61189 6.69388  1.000 52.05368 ? 5   ARG A NE  1 
ATOM   32   C  CZ  . ARG A 1 5  ? 17.83549  17.15393 6.60458  1.000 50.72411 ? 5   ARG A CZ  1 
ATOM   33   N  NH1 . ARG A 1 5  ? 18.25893  17.72250 5.48742  1.000 49.38286 ? 5   ARG A NH1 1 
ATOM   34   N  NH2 . ARG A 1 5  ? 18.63891  17.12582 7.66396  1.000 47.29748 ? 5   ARG A NH2 1 
ATOM   35   N  N   . ALA A 1 6  ? 9.99758   18.42566 5.16681  1.000 34.78276 ? 6   ALA A N   1 
ATOM   36   C  CA  . ALA A 1 6  ? 9.09652   19.57387 5.19690  1.000 30.59610 ? 6   ALA A CA  1 
ATOM   37   C  C   . ALA A 1 6  ? 8.16882   19.50959 6.40478  1.000 27.42537 ? 6   ALA A C   1 
ATOM   38   O  O   . ALA A 1 6  ? 8.02092   20.49030 7.14322  1.000 24.86151 ? 6   ALA A O   1 
ATOM   39   C  CB  . ALA A 1 6  ? 8.29138   19.64552 3.89915  1.000 31.71256 ? 6   ALA A CB  1 
ATOM   40   N  N   . LEU A 1 7  ? 7.55133   18.35556 6.63162  1.000 23.89602 ? 7   LEU A N   1 
ATOM   41   C  CA  . LEU A 1 7  ? 6.60905   18.21150 7.73217  1.000 18.58882 ? 7   LEU A CA  1 
ATOM   42   C  C   . LEU A 1 7  ? 7.34503   18.17766 9.06779  1.000 19.11475 ? 7   LEU A C   1 
ATOM   43   O  O   . LEU A 1 7  ? 8.30089   17.41579 9.24228  1.000 23.44218 ? 7   LEU A O   1 
ATOM   44   C  CB  . LEU A 1 7  ? 5.78848   16.93595 7.54847  1.000 21.23770 ? 7   LEU A CB  1 
ATOM   45   C  CG  . LEU A 1 7  ? 4.67374   16.66512 8.56071  1.000 19.08045 ? 7   LEU A CG  1 
ATOM   46   C  CD1 . LEU A 1 7  ? 3.65145   17.79627 8.57050  1.000 19.22183 ? 7   LEU A CD1 1 
ATOM   47   C  CD2 . LEU A 1 7  ? 4.01251   15.32022 8.28272  1.000 21.28437 ? 7   LEU A CD2 1 
ATOM   48   N  N   . THR A 1 8  ? 6.89850   19.00705 10.00898 1.000 17.87724 ? 8   THR A N   1 
ATOM   49   C  CA  . THR A 1 8  ? 7.40677   19.01614 11.37137 1.000 16.42089 ? 8   THR A CA  1 
ATOM   50   C  C   . THR A 1 8  ? 6.26932   18.72905 12.33756 1.000 17.88798 ? 8   THR A C   1 
ATOM   51   O  O   . THR A 1 8  ? 5.09276   18.95419 12.03238 1.000 17.71074 ? 8   THR A O   1 
ATOM   52   C  CB  . THR A 1 8  ? 8.03095   20.36244 11.75651 1.000 18.01137 ? 8   THR A CB  1 
ATOM   53   O  OG1 . THR A 1 8  ? 7.02840   21.38259 11.67628 1.000 16.79392 ? 8   THR A OG1 1 
ATOM   54   C  CG2 . THR A 1 8  ? 9.18738   20.71212 10.82941 1.000 17.88038 ? 8   THR A CG2 1 
ATOM   55   N  N   . LEU A 1 9  ? 6.63939   18.23995 13.52144 1.000 15.05438 ? 9   LEU A N   1 
ATOM   56   C  CA  . LEU A 1 9  ? 5.66068   18.10051 14.59065 1.000 15.40160 ? 9   LEU A CA  1 
ATOM   57   C  C   . LEU A 1 9  ? 5.12132   19.45973 15.01302 1.000 17.96678 ? 9   LEU A C   1 
ATOM   58   O  O   . LEU A 1 9  ? 3.94305   19.58170 15.36237 1.000 14.37626 ? 9   LEU A O   1 
ATOM   59   C  CB  . LEU A 1 9  ? 6.28936   17.37830 15.78266 1.000 18.74214 ? 9   LEU A CB  1 
ATOM   60   C  CG  . LEU A 1 9  ? 6.80818   15.95924 15.51364 1.000 16.38361 ? 9   LEU A CG  1 
ATOM   61   C  CD1 . LEU A 1 9  ? 7.58156   15.44421 16.72112 1.000 16.12258 ? 9   LEU A CD1 1 
ATOM   62   C  CD2 . LEU A 1 9  ? 5.68363   15.00182 15.14148 1.000 19.01841 ? 9   LEU A CD2 1 
ATOM   63   N  N   . GLU A 1 10 ? 5.95478   20.50120 14.96124 1.000 14.72443 ? 10  GLU A N   1 
ATOM   64   C  CA  . GLU A 1 10 ? 5.46881   21.82061 15.34789 1.000 17.69844 ? 10  GLU A CA  1 
ATOM   65   C  C   . GLU A 1 10 ? 4.38057   22.29413 14.39214 1.000 16.92168 ? 10  GLU A C   1 
ATOM   66   O  O   . GLU A 1 10 ? 3.38752   22.89157 14.82255 1.000 17.73205 ? 10  GLU A O   1 
ATOM   67   C  CB  . GLU A 1 10 ? 6.62817   22.81884 15.40773 1.000 20.10971 ? 10  GLU A CB  1 
ATOM   68   C  CG  . GLU A 1 10 ? 6.24899   24.18728 15.97934 1.000 28.20924 ? 10  GLU A CG  1 
ATOM   69   C  CD  . GLU A 1 10 ? 5.67923   25.15257 14.95627 1.000 48.76000 ? 10  GLU A CD  1 
ATOM   70   O  OE1 . GLU A 1 10 ? 5.26647   26.26133 15.35710 1.000 42.15333 ? 10  GLU A OE1 1 
ATOM   71   O  OE2 . GLU A 1 10 ? 5.67939   24.82330 13.74876 1.000 39.23099 ? 10  GLU A OE2 1 
ATOM   72   N  N   . ALA A 1 11 ? 4.54417   22.02553 13.09440 1.000 16.56177 ? 11  ALA A N   1 
ATOM   73   C  CA  . ALA A 1 11 ? 3.51178   22.39368 12.13109 1.000 13.75962 ? 11  ALA A CA  1 
ATOM   74   C  C   . ALA A 1 11 ? 2.22787   21.62217 12.39098 1.000 17.86172 ? 11  ALA A C   1 
ATOM   75   O  O   . ALA A 1 11 ? 1.12857   22.16977 12.25251 1.000 13.43856 ? 11  ALA A O   1 
ATOM   76   C  CB  . ALA A 1 11 ? 3.99993   22.15829 10.70363 1.000 15.53774 ? 11  ALA A CB  1 
ATOM   77   N  N   . LEU A 1 12 ? 2.34679   20.34931 12.77892 1.000 12.37574 ? 12  LEU A N   1 
ATOM   78   C  CA  . LEU A 1 12 ? 1.16412   19.57896 13.14181 1.000 12.70310 ? 12  LEU A CA  1 
ATOM   79   C  C   . LEU A 1 12 ? 0.50496   20.14209 14.39159 1.000 15.48977 ? 12  LEU A C   1 
ATOM   80   O  O   . LEU A 1 12 ? -0.72678  20.14418 14.49741 1.000 15.96015 ? 12  LEU A O   1 
ATOM   81   C  CB  . LEU A 1 12 ? 1.54434   18.11407 13.35114 1.000 13.41613 ? 12  LEU A CB  1 
ATOM   82   C  CG  . LEU A 1 12 ? 2.00227   17.39711 12.08186 1.000 15.16832 ? 12  LEU A CG  1 
ATOM   83   C  CD1 . LEU A 1 12 ? 2.46738   15.99092 12.41758 1.000 15.06674 ? 12  LEU A CD1 1 
ATOM   84   C  CD2 . LEU A 1 12 ? 0.87728   17.36615 11.05053 1.000 12.81790 ? 12  LEU A CD2 1 
ATOM   85   N  N   . ARG A 1 13 ? 1.30267   20.64274 15.33761 1.000 16.18282 ? 13  ARG A N   1 
ATOM   86   C  CA  . ARG A 1 13 ? 0.72297   21.24570 16.53196 1.000 13.26633 ? 13  ARG A CA  1 
ATOM   87   C  C   . ARG A 1 13 ? 0.00978   22.55326 16.20225 1.000 16.76528 ? 13  ARG A C   1 
ATOM   88   O  O   . ARG A 1 13 ? -1.01798  22.87134 16.81082 1.000 15.13451 ? 13  ARG A O   1 
ATOM   89   C  CB  . ARG A 1 13 ? 1.80647   21.47186 17.58768 1.000 14.85618 ? 13  ARG A CB  1 
ATOM   90   C  CG  . ARG A 1 13 ? 2.05833   20.25343 18.45130 1.000 22.18573 ? 13  ARG A CG  1 
ATOM   91   C  CD  . ARG A 1 13 ? 3.28948   20.41843 19.32688 1.000 25.93244 ? 13  ARG A CD  1 
ATOM   92   N  NE  . ARG A 1 13 ? 3.85751   19.12454 19.68804 1.000 24.51744 ? 13  ARG A NE  1 
ATOM   93   C  CZ  . ARG A 1 13 ? 5.11127   18.76829 19.45114 1.000 26.13350 ? 13  ARG A CZ  1 
ATOM   94   N  NH1 . ARG A 1 13 ? 5.97071   19.60222 18.88932 1.000 23.89214 ? 13  ARG A NH1 1 
ATOM   95   N  NH2 . ARG A 1 13 ? 5.51176   17.54308 19.78213 1.000 29.26801 ? 13  ARG A NH2 1 
ATOM   96   N  N   . VAL A 1 14 ? 0.53881   23.32540 15.24576 1.000 13.44121 ? 14  VAL A N   1 
ATOM   97   C  CA  . VAL A 1 14 ? -0.15889  24.52872 14.78846 1.000 16.45438 ? 14  VAL A CA  1 
ATOM   98   C  C   . VAL A 1 14 ? -1.50104  24.15070 14.18196 1.000 13.63248 ? 14  VAL A C   1 
ATOM   99   O  O   . VAL A 1 14 ? -2.53026  24.78459 14.44193 1.000 15.12611 ? 14  VAL A O   1 
ATOM   100  C  CB  . VAL A 1 14 ? 0.71276   25.29556 13.77706 1.000 14.91343 ? 14  VAL A CB  1 
ATOM   101  C  CG1 . VAL A 1 14 ? -0.10252  26.37556 13.06903 1.000 16.02856 ? 14  VAL A CG1 1 
ATOM   102  C  CG2 . VAL A 1 14 ? 1.91964   25.89858 14.46918 1.000 15.69024 ? 14  VAL A CG2 1 
ATOM   103  N  N   . MET A 1 15 ? -1.49835  23.09759 13.37329 1.000 13.52713 ? 15  MET A N   1 
ATOM   104  C  CA  . MET A 1 15 ? -2.70040  22.58656 12.73531 1.000 12.96761 ? 15  MET A CA  1 
ATOM   105  C  C   . MET A 1 15 ? -3.73670  22.18695 13.78079 1.000 14.74203 ? 15  MET A C   1 
ATOM   106  O  O   . MET A 1 15 ? -4.92052  22.53422 13.66913 1.000 14.95412 ? 15  MET A O   1 
ATOM   107  C  CB  . MET A 1 15 ? -2.26445  21.38733 11.90901 1.000 12.26947 ? 15  MET A CB  1 
ATOM   108  C  CG  . MET A 1 15 ? -1.71733  21.76326 10.56516 1.000 14.65771 ? 15  MET A CG  1 
ATOM   109  S  SD  . MET A 1 15 ? -1.78857  20.42161 9.39617  1.000 19.07137 ? 15  MET A SD  1 
ATOM   110  C  CE  . MET A 1 15 ? -0.18221  20.59263 8.63692  1.000 21.93990 ? 15  MET A CE  1 
ATOM   111  N  N   . ASP A 1 16 ? -3.29200  21.46808 14.81820 1.000 13.95384 ? 16  ASP A N   1 
ATOM   112  C  CA  . ASP A 1 16 ? -4.17918  21.02995 15.89370 1.000 17.12408 ? 16  ASP A CA  1 
ATOM   113  C  C   . ASP A 1 16 ? -4.79408  22.21748 16.61895 1.000 16.60390 ? 16  ASP A C   1 
ATOM   114  O  O   . ASP A 1 16 ? -5.98995  22.21496 16.93136 1.000 17.21702 ? 16  ASP A O   1 
ATOM   115  C  CB  . ASP A 1 16 ? -3.39970  20.15013 16.87878 1.000 14.17314 ? 16  ASP A CB  1 
ATOM   116  C  CG  . ASP A 1 16 ? -4.21099  19.76162 18.10101 1.000 17.61506 ? 16  ASP A CG  1 
ATOM   117  O  OD1 . ASP A 1 16 ? -5.24800  19.08393 17.95016 1.000 18.56038 ? 16  ASP A OD1 1 
ATOM   118  O  OD2 . ASP A 1 16 ? -3.81021  20.14061 19.22263 1.000 20.34998 ? 16  ASP A OD2 1 
ATOM   119  N  N   . ALA A 1 17 ? -3.98691  23.24004 16.90519 1.000 15.73194 ? 17  ALA A N   1 
ATOM   120  C  CA  . ALA A 1 17 ? -4.49798  24.39439 17.63309 1.000 17.27554 ? 17  ALA A CA  1 
ATOM   121  C  C   . ALA A 1 17 ? -5.47873  25.19127 16.78412 1.000 18.47641 ? 17  ALA A C   1 
ATOM   122  O  O   . ALA A 1 17 ? -6.48860  25.68583 17.29716 1.000 19.95552 ? 17  ALA A O   1 
ATOM   123  C  CB  . ALA A 1 17 ? -3.34008  25.27599 18.10017 1.000 15.50709 ? 17  ALA A CB  1 
ATOM   124  N  N   . ILE A 1 18 ? -5.20859  25.32103 15.48227 1.000 15.73169 ? 18  ILE A N   1 
ATOM   125  C  CA  . ILE A 1 18 ? -6.14352  26.03403 14.61616 1.000 19.17369 ? 18  ILE A CA  1 
ATOM   126  C  C   . ILE A 1 18 ? -7.48938  25.32196 14.59638 1.000 22.26502 ? 18  ILE A C   1 
ATOM   127  O  O   . ILE A 1 18 ? -8.54823  25.96009 14.64735 1.000 19.17011 ? 18  ILE A O   1 
ATOM   128  C  CB  . ILE A 1 18 ? -5.55719  26.19286 13.20096 1.000 16.68189 ? 18  ILE A CB  1 
ATOM   129  C  CG1 . ILE A 1 18 ? -4.42906  27.22861 13.21056 1.000 17.56951 ? 18  ILE A CG1 1 
ATOM   130  C  CG2 . ILE A 1 18 ? -6.63973  26.61879 12.21092 1.000 17.04573 ? 18  ILE A CG2 1 
ATOM   131  C  CD1 . ILE A 1 18 ? -3.51781  27.14730 12.00784 1.000 18.68599 ? 18  ILE A CD1 1 
ATOM   132  N  N   . ASP A 1 19 ? -7.47028  23.98961 14.55046 1.000 17.08796 ? 19  ASP A N   1 
ATOM   133  C  CA  . ASP A 1 19 ? -8.71732  23.22886 14.54885 1.000 18.71461 ? 19  ASP A CA  1 
ATOM   134  C  C   . ASP A 1 19 ? -9.45965  23.36848 15.87354 1.000 19.92406 ? 19  ASP A C   1 
ATOM   135  O  O   . ASP A 1 19 ? -10.66393 23.64898 15.89417 1.000 20.62268 ? 19  ASP A O   1 
ATOM   136  C  CB  . ASP A 1 19 ? -8.43022  21.75843 14.25016 1.000 17.25479 ? 19  ASP A CB  1 
ATOM   137  C  CG  . ASP A 1 19 ? -9.68988  20.92012 14.20137 1.000 20.99335 ? 19  ASP A CG  1 
ATOM   138  O  OD1 . ASP A 1 19 ? -10.59402 21.24922 13.40785 1.000 20.88254 ? 19  ASP A OD1 1 
ATOM   139  O  OD2 . ASP A 1 19 ? -9.76970  19.92561 14.94659 1.000 19.07645 ? 19  ASP A OD2 1 
ATOM   140  N  N   . ARG A 1 20 ? -8.75812  23.16928 16.99217 1.000 18.10631 ? 20  ARG A N   1 
ATOM   141  C  CA  . ARG A 1 20 ? -9.42041  23.17856 18.29402 1.000 23.35991 ? 20  ARG A CA  1 
ATOM   142  C  C   . ARG A 1 20 ? -9.96022  24.56051 18.63260 1.000 24.70164 ? 20  ARG A C   1 
ATOM   143  O  O   . ARG A 1 20 ? -11.08971 24.69000 19.12021 1.000 31.45667 ? 20  ARG A O   1 
ATOM   144  C  CB  . ARG A 1 20 ? -8.44917  22.72579 19.37967 1.000 22.59012 ? 20  ARG A CB  1 
ATOM   145  C  CG  . ARG A 1 20 ? -8.28569  21.22769 19.50802 1.000 18.33048 ? 20  ARG A CG  1 
ATOM   146  C  CD  . ARG A 1 20 ? -7.40074  20.86178 20.70822 1.000 24.45776 ? 20  ARG A CD  1 
ATOM   147  N  NE  . ARG A 1 20 ? -6.00264  21.24937 20.53332 1.000 28.69373 ? 20  ARG A NE  1 
ATOM   148  C  CZ  . ARG A 1 20 ? -5.47940  22.40417 20.92678 1.000 28.01475 ? 20  ARG A CZ  1 
ATOM   149  N  NH1 . ARG A 1 20 ? -6.19909  23.30485 21.57641 1.000 28.92140 ? 20  ARG A NH1 1 
ATOM   150  N  NH2 . ARG A 1 20 ? -4.19692  22.65660 20.67705 1.000 23.68260 ? 20  ARG A NH2 1 
ATOM   151  N  N   . ARG A 1 21 ? -9.16606  25.60311 18.39280 1.000 21.92761 ? 21  ARG A N   1 
ATOM   152  C  CA  . ARG A 1 21 ? -9.54647  26.95205 18.78948 1.000 25.84892 ? 21  ARG A CA  1 
ATOM   153  C  C   . ARG A 1 21 ? -10.36281 27.68546 17.73653 1.000 28.61675 ? 21  ARG A C   1 
ATOM   154  O  O   . ARG A 1 21 ? -10.98231 28.70602 18.05905 1.000 29.50689 ? 21  ARG A O   1 
ATOM   155  C  CB  . ARG A 1 21 ? -8.30208  27.77137 19.14380 1.000 27.04381 ? 21  ARG A CB  1 
ATOM   156  C  CG  . ARG A 1 21 ? -7.44633  27.11046 20.20729 1.000 24.08327 ? 21  ARG A CG  1 
ATOM   157  C  CD  . ARG A 1 21 ? -8.23669  26.99253 21.50701 1.000 30.89018 ? 21  ARG A CD  1 
ATOM   158  N  NE  . ARG A 1 21 ? -8.44920  28.28700 22.14425 1.000 43.43223 ? 21  ARG A NE  1 
ATOM   159  C  CZ  . ARG A 1 21 ? -7.54118  28.92290 22.87128 1.000 41.72069 ? 21  ARG A CZ  1 
ATOM   160  N  NH1 . ARG A 1 21 ? -6.36743  28.37879 23.13857 1.000 41.06502 ? 21  ARG A NH1 1 
ATOM   161  N  NH2 . ARG A 1 21 ? -7.82604  30.12700 23.35922 1.000 49.68685 ? 21  ARG A NH2 1 
ATOM   162  N  N   . GLY A 1 22 ? -10.37711 27.20081 16.49592 1.000 26.43612 ? 22  GLY A N   1 
ATOM   163  C  CA  . GLY A 1 22 ? -11.29283 27.69226 15.48840 1.000 28.02196 ? 22  GLY A CA  1 
ATOM   164  C  C   . GLY A 1 22 ? -10.79699 28.84503 14.64290 1.000 32.00395 ? 22  GLY A C   1 
ATOM   165  O  O   . GLY A 1 22 ? -11.49434 29.23990 13.69865 1.000 34.78843 ? 22  GLY A O   1 
ATOM   166  N  N   . SER A 1 23 ? -9.62292  29.39650 14.93603 1.000 29.66088 ? 23  SER A N   1 
ATOM   167  C  CA  . SER A 1 23 ? -9.11134  30.51766 14.16284 1.000 33.48157 ? 23  SER A CA  1 
ATOM   168  C  C   . SER A 1 23 ? -7.59874  30.56194 14.29477 1.000 26.25378 ? 23  SER A C   1 
ATOM   169  O  O   . SER A 1 23 ? -7.02786  30.06227 15.26702 1.000 28.02677 ? 23  SER A O   1 
ATOM   170  C  CB  . SER A 1 23 ? -9.72799  31.84418 14.62570 1.000 35.07290 ? 23  SER A CB  1 
ATOM   171  O  OG  . SER A 1 23 ? -9.24111  32.21255 15.90755 1.000 30.59387 ? 23  SER A OG  1 
ATOM   172  N  N   . PHE A 1 24 ? -6.95448  31.16447 13.29220 1.000 24.82719 ? 24  PHE A N   1 
ATOM   173  C  CA  . PHE A 1 24 ? -5.52599  31.43407 13.40381 1.000 26.66697 ? 24  PHE A CA  1 
ATOM   174  C  C   . PHE A 1 24 ? -5.23541  32.34398 14.59301 1.000 25.34491 ? 24  PHE A C   1 
ATOM   175  O  O   . PHE A 1 24 ? -4.22208  32.17691 15.28065 1.000 23.06794 ? 24  PHE A O   1 
ATOM   176  C  CB  . PHE A 1 24 ? -5.00190  32.06453 12.11109 1.000 27.37643 ? 24  PHE A CB  1 
ATOM   177  C  CG  . PHE A 1 24 ? -4.59214  31.06379 11.05888 1.000 22.62566 ? 24  PHE A CG  1 
ATOM   178  C  CD1 . PHE A 1 24 ? -5.53515  30.26778 10.42707 1.000 29.09834 ? 24  PHE A CD1 1 
ATOM   179  C  CD2 . PHE A 1 24 ? -3.26130  30.92667 10.70098 1.000 21.93394 ? 24  PHE A CD2 1 
ATOM   180  C  CE1 . PHE A 1 24 ? -5.15288  29.34708 9.45789  1.000 24.61235 ? 24  PHE A CE1 1 
ATOM   181  C  CE2 . PHE A 1 24 ? -2.87147  30.01011 9.74085  1.000 21.68268 ? 24  PHE A CE2 1 
ATOM   182  C  CZ  . PHE A 1 24 ? -3.81787  29.22309 9.11293  1.000 19.74445 ? 24  PHE A CZ  1 
ATOM   183  N  N   . ALA A 1 25 ? -6.11966  33.30944 14.85379 1.000 32.05259 ? 25  ALA A N   1 
ATOM   184  C  CA  . ALA A 1 25 ? -5.87385  34.28082 15.91650 1.000 28.90266 ? 25  ALA A CA  1 
ATOM   185  C  C   . ALA A 1 25 ? -5.86438  33.61664 17.28755 1.000 29.33957 ? 25  ALA A C   1 
ATOM   186  O  O   . ALA A 1 25 ? -4.94854  33.83901 18.08849 1.000 26.76156 ? 25  ALA A O   1 
ATOM   187  C  CB  . ALA A 1 25 ? -6.92405  35.39074 15.86351 1.000 35.47814 ? 25  ALA A CB  1 
ATOM   188  N  N   . ALA A 1 26 ? -6.88005  32.79996 17.57944 1.000 27.98342 ? 26  ALA A N   1 
ATOM   189  C  CA  . ALA A 1 26 ? -6.94879  32.14839 18.88396 1.000 28.78775 ? 26  ALA A CA  1 
ATOM   190  C  C   . ALA A 1 26 ? -5.86695  31.08521 19.03353 1.000 23.15404 ? 26  ALA A C   1 
ATOM   191  O  O   . ALA A 1 26 ? -5.31276  30.90656 20.12448 1.000 24.27304 ? 26  ALA A O   1 
ATOM   192  C  CB  . ALA A 1 26 ? -8.33484  31.54098 19.09498 1.000 30.71303 ? 26  ALA A CB  1 
ATOM   193  N  N   . ALA A 1 27 ? -5.55928  30.36028 17.95392 1.000 22.97299 ? 27  ALA A N   1 
ATOM   194  C  CA  . ALA A 1 27 ? -4.46396  29.39591 18.00811 1.000 19.80344 ? 27  ALA A CA  1 
ATOM   195  C  C   . ALA A 1 27 ? -3.13561  30.09014 18.27800 1.000 18.74207 ? 27  ALA A C   1 
ATOM   196  O  O   . ALA A 1 27 ? -2.32220  29.60562 19.07348 1.000 21.37922 ? 27  ALA A O   1 
ATOM   197  C  CB  . ALA A 1 27 ? -4.39344  28.59872 16.70544 1.000 20.33376 ? 27  ALA A CB  1 
ATOM   198  N  N   . ALA A 1 28 ? -2.89760  31.22854 17.62326 1.000 18.76899 ? 28  ALA A N   1 
ATOM   199  C  CA  . ALA A 1 28 ? -1.66487  31.97223 17.86317 1.000 20.17094 ? 28  ALA A CA  1 
ATOM   200  C  C   . ALA A 1 28 ? -1.59252  32.45439 19.30374 1.000 21.58243 ? 28  ALA A C   1 
ATOM   201  O  O   . ALA A 1 28 ? -0.52864  32.40568 19.93419 1.000 20.36385 ? 28  ALA A O   1 
ATOM   202  C  CB  . ALA A 1 28 ? -1.56800  33.15200 16.89663 1.000 21.43309 ? 28  ALA A CB  1 
ATOM   203  N  N   . ASP A 1 29 ? -2.71918  32.92582 19.83629 1.000 23.92694 ? 29  ASP A N   1 
ATOM   204  C  CA  . ASP A 1 29 ? -2.78943  33.29261 21.24534 1.000 26.64191 ? 29  ASP A CA  1 
ATOM   205  C  C   . ASP A 1 29 ? -2.39698  32.11681 22.13076 1.000 23.75428 ? 29  ASP A C   1 
ATOM   206  O  O   . ASP A 1 29 ? -1.61659  32.26906 23.07640 1.000 27.18276 ? 29  ASP A O   1 
ATOM   207  C  CB  . ASP A 1 29 ? -4.20130  33.76950 21.57882 1.000 31.89888 ? 29  ASP A CB  1 
ATOM   208  C  CG  . ASP A 1 29 ? -4.20776  35.02612 22.41200 1.000 48.94596 ? 29  ASP A CG  1 
ATOM   209  O  OD1 . ASP A 1 29 ? -3.68541  34.98521 23.54221 1.000 45.63988 ? 29  ASP A OD1 1 
ATOM   210  O  OD2 . ASP A 1 29 ? -4.73986  36.05272 21.93670 1.000 49.41402 ? 29  ASP A OD2 1 
ATOM   211  N  N   . GLU A 1 30 ? -2.92146  30.92601 21.82502 1.000 23.37681 ? 30  GLU A N   1 
ATOM   212  C  CA  . GLU A 1 30 ? -2.60590  29.75015 22.63022 1.000 25.93721 ? 30  GLU A CA  1 
ATOM   213  C  C   . GLU A 1 30 ? -1.12263  29.41580 22.57497 1.000 25.96924 ? 30  GLU A C   1 
ATOM   214  O  O   . GLU A 1 30 ? -0.52006  29.06934 23.59813 1.000 23.48899 ? 30  GLU A O   1 
ATOM   215  C  CB  . GLU A 1 30 ? -3.43222  28.55101 22.16876 1.000 27.66039 ? 30  GLU A CB  1 
ATOM   216  C  CG  . GLU A 1 30 ? -3.16300  27.28784 22.98273 1.000 30.64487 ? 30  GLU A CG  1 
ATOM   217  C  CD  . GLU A 1 30 ? -3.89002  26.07551 22.44287 1.000 31.82810 ? 30  GLU A CD  1 
ATOM   218  O  OE1 . GLU A 1 30 ? -5.12367  26.15153 22.27430 1.000 35.05403 ? 30  GLU A OE1 1 
ATOM   219  O  OE2 . GLU A 1 30 ? -3.22969  25.04914 22.18736 1.000 36.52712 ? 30  GLU A OE2 1 
ATOM   220  N  N   . LEU A 1 31 ? -0.51343  29.52165 21.39573 1.000 19.87677 ? 31  LEU A N   1 
ATOM   221  C  CA  . LEU A 1 31 ? 0.87304   29.12119 21.20309 1.000 18.28723 ? 31  LEU A CA  1 
ATOM   222  C  C   . LEU A 1 31 ? 1.87085   30.21707 21.55645 1.000 20.05002 ? 31  LEU A C   1 
ATOM   223  O  O   . LEU A 1 31 ? 3.08020   29.97092 21.49978 1.000 23.93652 ? 31  LEU A O   1 
ATOM   224  C  CB  . LEU A 1 31 ? 1.09153   28.67703 19.75468 1.000 21.27935 ? 31  LEU A CB  1 
ATOM   225  C  CG  . LEU A 1 31 ? 0.23683   27.50924 19.25763 1.000 23.63034 ? 31  LEU A CG  1 
ATOM   226  C  CD1 . LEU A 1 31 ? 0.52148   27.22211 17.78455 1.000 20.31468 ? 31  LEU A CD1 1 
ATOM   227  C  CD2 . LEU A 1 31 ? 0.47164   26.26432 20.08996 1.000 25.34832 ? 31  LEU A CD2 1 
ATOM   228  N  N   . GLY A 1 32 ? 1.40273   31.40868 21.91136 1.000 22.09073 ? 32  GLY A N   1 
ATOM   229  C  CA  . GLY A 1 32 ? 2.29990   32.50803 22.23565 1.000 21.49807 ? 32  GLY A CA  1 
ATOM   230  C  C   . GLY A 1 32 ? 3.04864   33.07479 21.04855 1.000 26.54330 ? 32  GLY A C   1 
ATOM   231  O  O   . GLY A 1 32 ? 4.22417   33.44143 21.17868 1.000 25.30019 ? 32  GLY A O   1 
ATOM   232  N  N   . ARG A 1 33 ? 2.39754   33.15362 19.89132 1.000 18.80560 ? 33  ARG A N   1 
ATOM   233  C  CA  . ARG A 1 33 ? 3.01945   33.62615 18.66556 1.000 20.45146 ? 33  ARG A CA  1 
ATOM   234  C  C   . ARG A 1 33 ? 2.11257   34.66712 18.02360 1.000 18.34447 ? 33  ARG A C   1 
ATOM   235  O  O   . ARG A 1 33 ? 0.93137   34.77162 18.35716 1.000 20.60626 ? 33  ARG A O   1 
ATOM   236  C  CB  . ARG A 1 33 ? 3.26929   32.46682 17.68991 1.000 20.58685 ? 33  ARG A CB  1 
ATOM   237  C  CG  . ARG A 1 33 ? 4.33681   31.49547 18.14637 1.000 25.16075 ? 33  ARG A CG  1 
ATOM   238  C  CD  . ARG A 1 33 ? 5.63689   32.21343 18.44112 1.000 33.05626 ? 33  ARG A CD  1 
ATOM   239  N  NE  . ARG A 1 33 ? 6.47743   32.32991 17.25693 1.000 40.99888 ? 33  ARG A NE  1 
ATOM   240  C  CZ  . ARG A 1 33 ? 6.58678   33.42319 16.51547 1.000 42.07928 ? 33  ARG A CZ  1 
ATOM   241  N  NH1 . ARG A 1 33 ? 5.90321   34.52431 16.79615 1.000 28.05098 ? 33  ARG A NH1 1 
ATOM   242  N  NH2 . ARG A 1 33 ? 7.40045   33.41150 15.46422 1.000 40.51726 ? 33  ARG A NH2 1 
ATOM   243  N  N   . VAL A 1 34 ? 2.66741   35.44656 17.09824 1.000 19.84885 ? 34  VAL A N   1 
ATOM   244  C  CA  . VAL A 1 34 ? 1.83674   36.38153 16.34083 1.000 22.33842 ? 34  VAL A CA  1 
ATOM   245  C  C   . VAL A 1 34 ? 1.10976   35.57412 15.27128 1.000 19.87256 ? 34  VAL A C   1 
ATOM   246  O  O   . VAL A 1 34 ? 1.64206   34.56039 14.80011 1.000 17.96639 ? 34  VAL A O   1 
ATOM   247  C  CB  . VAL A 1 34 ? 2.66091   37.52953 15.73373 1.000 19.60091 ? 34  VAL A CB  1 
ATOM   248  C  CG1 . VAL A 1 34 ? 3.33606   38.33031 16.83427 1.000 17.64710 ? 34  VAL A CG1 1 
ATOM   249  C  CG2 . VAL A 1 34 ? 3.68212   37.00711 14.73169 1.000 20.58289 ? 34  VAL A CG2 1 
ATOM   250  N  N   . PRO A 1 35 ? -0.10480  35.96088 14.87588 1.000 19.25829 ? 35  PRO A N   1 
ATOM   251  C  CA  . PRO A 1 35 ? -0.86295  35.11838 13.93624 1.000 20.56380 ? 35  PRO A CA  1 
ATOM   252  C  C   . PRO A 1 35 ? -0.15746  34.89096 12.61306 1.000 20.22890 ? 35  PRO A C   1 
ATOM   253  O  O   . PRO A 1 35 ? -0.29303  33.80788 12.03249 1.000 16.79106 ? 35  PRO A O   1 
ATOM   254  C  CB  . PRO A 1 35 ? -2.17497  35.89252 13.75376 1.000 23.16938 ? 35  PRO A CB  1 
ATOM   255  C  CG  . PRO A 1 35 ? -2.30170  36.72310 14.98844 1.000 23.43332 ? 35  PRO A CG  1 
ATOM   256  C  CD  . PRO A 1 35 ? -0.90052  37.09668 15.37157 1.000 19.43498 ? 35  PRO A CD  1 
ATOM   257  N  N   . SER A 1 36 ? 0.60801   35.86423 12.11813 1.000 18.88211 ? 36  SER A N   1 
ATOM   258  C  CA  . SER A 1 36 ? 1.26865   35.65996 10.83595 1.000 20.40003 ? 36  SER A CA  1 
ATOM   259  C  C   . SER A 1 36 ? 2.42429   34.67203 10.93224 1.000 17.16770 ? 36  SER A C   1 
ATOM   260  O  O   . SER A 1 36 ? 2.86524   34.15476 9.90103  1.000 18.78683 ? 36  SER A O   1 
ATOM   261  C  CB  . SER A 1 36 ? 1.75120   36.99346 10.26596 1.000 20.12249 ? 36  SER A CB  1 
ATOM   262  O  OG  . SER A 1 36 ? 0.66394   37.69145 9.68295  1.000 24.33088 ? 36  SER A OG  1 
ATOM   263  N  N   . ALA A 1 37 ? 2.92098   34.38911 12.13859 1.000 16.08666 ? 37  ALA A N   1 
ATOM   264  C  CA  . ALA A 1 37 ? 3.89834   33.31529 12.27917 1.000 17.89885 ? 37  ALA A CA  1 
ATOM   265  C  C   . ALA A 1 37 ? 3.26566   31.96558 11.97515 1.000 17.04193 ? 37  ALA A C   1 
ATOM   266  O  O   . ALA A 1 37 ? 3.90041   31.09597 11.36362 1.000 17.81413 ? 37  ALA A O   1 
ATOM   267  C  CB  . ALA A 1 37 ? 4.49694   33.31639 13.68332 1.000 17.75371 ? 37  ALA A CB  1 
ATOM   268  N  N   . LEU A 1 38 ? 2.01578   31.77371 12.39976 1.000 16.17759 ? 38  LEU A N   1 
ATOM   269  C  CA  . LEU A 1 38 ? 1.31439   30.53224 12.09663 1.000 16.86159 ? 38  LEU A CA  1 
ATOM   270  C  C   . LEU A 1 38 ? 0.99027   30.44377 10.61405 1.000 17.30229 ? 38  LEU A C   1 
ATOM   271  O  O   . LEU A 1 38 ? 1.09093   29.36876 10.01201 1.000 15.53121 ? 38  LEU A O   1 
ATOM   272  C  CB  . LEU A 1 38 ? 0.03615   30.42889 12.92701 1.000 17.12055 ? 38  LEU A CB  1 
ATOM   273  C  CG  . LEU A 1 38 ? 0.14548   29.81500 14.32533 1.000 17.41229 ? 38  LEU A CG  1 
ATOM   274  C  CD1 . LEU A 1 38 ? 1.11501   30.59009 15.21137 1.000 20.41306 ? 38  LEU A CD1 1 
ATOM   275  C  CD2 . LEU A 1 38 ? -1.22802  29.72277 14.97407 1.000 19.18024 ? 38  LEU A CD2 1 
ATOM   276  N  N   . SER A 1 39 ? 0.59757   31.57092 10.01303 1.000 15.49207 ? 39  SER A N   1 
ATOM   277  C  CA  . SER A 1 39 ? 0.38394   31.61605 8.57134  1.000 17.56178 ? 39  SER A CA  1 
ATOM   278  C  C   . SER A 1 39 ? 1.65112   31.24276 7.81595  1.000 18.71170 ? 39  SER A C   1 
ATOM   279  O  O   . SER A 1 39 ? 1.59220   30.53450 6.80502  1.000 15.74890 ? 39  SER A O   1 
ATOM   280  C  CB  . SER A 1 39 ? -0.09405  33.00999 8.15588  1.000 16.66180 ? 39  SER A CB  1 
ATOM   281  O  OG  . SER A 1 39 ? -1.37988  33.28649 8.68473  1.000 27.02173 ? 39  SER A OG  1 
ATOM   282  N  N   . TYR A 1 40 ? 2.80926   31.71044 8.28899  1.000 14.40605 ? 40  TYR A N   1 
ATOM   283  C  CA  . TYR A 1 40 ? 4.05817   31.39178 7.60402  1.000 16.93146 ? 40  TYR A CA  1 
ATOM   284  C  C   . TYR A 1 40 ? 4.36506   29.90054 7.68780  1.000 16.77090 ? 40  TYR A C   1 
ATOM   285  O  O   . TYR A 1 40 ? 4.71606   29.27293 6.68164  1.000 17.09255 ? 40  TYR A O   1 
ATOM   286  C  CB  . TYR A 1 40 ? 5.21370   32.20635 8.18754  1.000 15.30190 ? 40  TYR A CB  1 
ATOM   287  C  CG  . TYR A 1 40 ? 6.54948   31.86272 7.56163  1.000 18.92099 ? 40  TYR A CG  1 
ATOM   288  C  CD1 . TYR A 1 40 ? 6.89059   32.33855 6.29982  1.000 18.48619 ? 40  TYR A CD1 1 
ATOM   289  C  CD2 . TYR A 1 40 ? 7.45208   31.03303 8.21223  1.000 24.51085 ? 40  TYR A CD2 1 
ATOM   290  C  CE1 . TYR A 1 40 ? 8.10614   32.01950 5.71593  1.000 20.11850 ? 40  TYR A CE1 1 
ATOM   291  C  CE2 . TYR A 1 40 ? 8.67162   30.70810 7.63279  1.000 19.88558 ? 40  TYR A CE2 1 
ATOM   292  C  CZ  . TYR A 1 40 ? 8.99205   31.20311 6.38941  1.000 25.63578 ? 40  TYR A CZ  1 
ATOM   293  O  OH  . TYR A 1 40 ? 10.20110  30.87642 5.81298  1.000 29.40437 ? 40  TYR A OH  1 
ATOM   294  N  N   . THR A 1 41 ? 4.24703   29.31777 8.88438  1.000 16.84671 ? 41  THR A N   1 
ATOM   295  C  CA  . THR A 1 41 ? 4.52198   27.89017 9.04573  1.000 17.40154 ? 41  THR A CA  1 
ATOM   296  C  C   . THR A 1 41 ? 3.62354   27.04799 8.14647  1.000 17.26533 ? 41  THR A C   1 
ATOM   297  O  O   . THR A 1 41 ? 4.08249   26.08096 7.52284  1.000 18.49799 ? 41  THR A O   1 
ATOM   298  C  CB  . THR A 1 41 ? 4.34824   27.48175 10.50891 1.000 19.11350 ? 41  THR A CB  1 
ATOM   299  O  OG1 . THR A 1 41 ? 5.19801   28.28509 11.33699 1.000 18.24023 ? 41  THR A OG1 1 
ATOM   300  C  CG2 . THR A 1 41 ? 4.70183   26.01079 10.69857 1.000 19.33129 ? 41  THR A CG2 1 
ATOM   301  N  N   . MET A 1 42 ? 2.34121   27.40857 8.06231  1.000 14.75660 ? 42  MET A N   1 
ATOM   302  C  CA  . MET A 1 42 ? 1.40499   26.69933 7.19508  1.000 14.67188 ? 42  MET A CA  1 
ATOM   303  C  C   . MET A 1 42 ? 1.75110   26.87980 5.72395  1.000 17.18637 ? 42  MET A C   1 
ATOM   304  O  O   . MET A 1 42 ? 1.75131   25.91356 4.95146  1.000 14.97532 ? 42  MET A O   1 
ATOM   305  C  CB  . MET A 1 42 ? -0.01196  27.19464 7.47147  1.000 16.91897 ? 42  MET A CB  1 
ATOM   306  C  CG  . MET A 1 42 ? -0.70809  26.72012 8.76311  1.000 18.07253 ? 42  MET A CG  1 
ATOM   307  S  SD  . MET A 1 42 ? -0.60522  24.97657 9.26990  1.000 16.99710 ? 42  MET A SD  1 
ATOM   308  C  CE  . MET A 1 42 ? 1.08707   24.68160 9.79427  1.000 12.83191 ? 42  MET A CE  1 
ATOM   309  N  N   . GLN A 1 43 ? 2.05554   28.10852 5.31704  1.000 14.83464 ? 43  GLN A N   1 
ATOM   310  C  CA  . GLN A 1 43 ? 2.27433   28.37263 3.90114  1.000 17.05541 ? 43  GLN A CA  1 
ATOM   311  C  C   . GLN A 1 43 ? 3.61469   27.82762 3.42606  1.000 15.84994 ? 43  GLN A C   1 
ATOM   312  O  O   . GLN A 1 43 ? 3.73279   27.40271 2.27209  1.000 19.75606 ? 43  GLN A O   1 
ATOM   313  C  CB  . GLN A 1 43 ? 2.15652   29.87527 3.64299  1.000 14.17489 ? 43  GLN A CB  1 
ATOM   314  C  CG  . GLN A 1 43 ? 0.70621   30.35196 3.67530  1.000 15.77248 ? 43  GLN A CG  1 
ATOM   315  C  CD  . GLN A 1 43 ? 0.56849   31.84775 3.88522  1.000 17.18978 ? 43  GLN A CD  1 
ATOM   316  O  OE1 . GLN A 1 43 ? 1.54781   32.54619 4.11911  1.000 17.77767 ? 43  GLN A OE1 1 
ATOM   317  N  NE2 . GLN A 1 43 ? -0.65885  32.33766 3.83192  1.000 20.35380 ? 43  GLN A NE2 1 
ATOM   318  N  N   . LYS A 1 44 ? 4.62911   27.81607 4.29260  1.000 17.94244 ? 44  LYS A N   1 
ATOM   319  C  CA  . LYS A 1 44 ? 5.90128   27.21361 3.90987  1.000 18.45556 ? 44  LYS A CA  1 
ATOM   320  C  C   . LYS A 1 44 ? 5.74799   25.71154 3.69551  1.000 17.94723 ? 44  LYS A C   1 
ATOM   321  O  O   . LYS A 1 44 ? 6.36358   25.13889 2.78950  1.000 19.14869 ? 44  LYS A O   1 
ATOM   322  C  CB  . LYS A 1 44 ? 6.95948   27.50672 4.97520  1.000 24.20057 ? 44  LYS A CB  1 
ATOM   323  C  CG  . LYS A 1 44 ? 8.35790   27.05498 4.59505  1.000 26.49651 ? 44  LYS A CG  1 
ATOM   324  C  CD  . LYS A 1 44 ? 8.84768   27.81733 3.36625  1.000 32.09874 ? 44  LYS A CD  1 
ATOM   325  C  CE  . LYS A 1 44 ? 10.30508  27.52560 3.06302  1.000 40.61321 ? 44  LYS A CE  1 
ATOM   326  N  NZ  . LYS A 1 44 ? 10.90597  28.57001 2.18659  1.000 41.39591 ? 44  LYS A NZ  1 
ATOM   327  N  N   . LEU A 1 45 ? 4.91871   25.06132 4.51172  1.000 15.61610 ? 45  LEU A N   1 
ATOM   328  C  CA  . LEU A 1 45 ? 4.66469   23.63480 4.33442  1.000 19.25842 ? 45  LEU A CA  1 
ATOM   329  C  C   . LEU A 1 45 ? 3.88994   23.36526 3.05059  1.000 18.93538 ? 45  LEU A C   1 
ATOM   330  O  O   . LEU A 1 45 ? 4.21348   22.42833 2.30882  1.000 17.98966 ? 45  LEU A O   1 
ATOM   331  C  CB  . LEU A 1 45 ? 3.90860   23.09357 5.54729  1.000 17.70068 ? 45  LEU A CB  1 
ATOM   332  C  CG  . LEU A 1 45 ? 3.52442   21.61984 5.48586  1.000 16.33354 ? 45  LEU A CG  1 
ATOM   333  C  CD1 . LEU A 1 45 ? 4.78010   20.75031 5.48539  1.000 16.21756 ? 45  LEU A CD1 1 
ATOM   334  C  CD2 . LEU A 1 45 ? 2.63251   21.28571 6.66148  1.000 17.41641 ? 45  LEU A CD2 1 
ATOM   335  N  N   . GLU A 1 46 ? 2.85571   24.16915 2.78130  1.000 15.25471 ? 46  GLU A N   1 
ATOM   336  C  CA  . GLU A 1 46 ? 2.12320   24.07677 1.51853  1.000 18.90120 ? 46  GLU A CA  1 
ATOM   337  C  C   . GLU A 1 46 ? 3.06574   24.15030 0.32859  1.000 19.23560 ? 46  GLU A C   1 
ATOM   338  O  O   . GLU A 1 46 ? 2.95668   23.37725 -0.63116 1.000 23.28896 ? 46  GLU A O   1 
ATOM   339  C  CB  . GLU A 1 46 ? 1.11129   25.21892 1.42446  1.000 17.56551 ? 46  GLU A CB  1 
ATOM   340  C  CG  . GLU A 1 46 ? -0.05911  25.09416 2.34271  1.000 17.86728 ? 46  GLU A CG  1 
ATOM   341  C  CD  . GLU A 1 46 ? -0.99471  26.26152 2.19570  1.000 17.76697 ? 46  GLU A CD  1 
ATOM   342  O  OE1 . GLU A 1 46 ? -0.49904  27.38140 1.94623  1.000 18.87820 ? 46  GLU A OE1 1 
ATOM   343  O  OE2 . GLU A 1 46 ? -2.21751  26.05735 2.31361  1.000 19.87756 ? 46  GLU A OE2 1 
ATOM   344  N  N   . GLU A 1 47 ? 3.98873   25.10413 0.37216  1.000 16.57440 ? 47  GLU A N   1 
ATOM   345  C  CA  . GLU A 1 47 ? 4.88090   25.33359 -0.75163 1.000 14.55385 ? 47  GLU A CA  1 
ATOM   346  C  C   . GLU A 1 47 ? 5.88968   24.20284 -0.89189 1.000 19.12084 ? 47  GLU A C   1 
ATOM   347  O  O   . GLU A 1 47 ? 6.22067   23.79347 -2.00946 1.000 22.20607 ? 47  GLU A O   1 
ATOM   348  C  CB  . GLU A 1 47 ? 5.58107   26.67646 -0.56349 1.000 17.72523 ? 47  GLU A CB  1 
ATOM   349  C  CG  . GLU A 1 47 ? 4.68628   27.87632 -0.86284 1.000 19.94948 ? 47  GLU A CG  1 
ATOM   350  C  CD  . GLU A 1 47 ? 5.00447   29.06785 0.01860  1.000 17.66911 ? 47  GLU A CD  1 
ATOM   351  O  OE1 . GLU A 1 47 ? 6.17964   29.20749 0.40651  1.000 23.15683 ? 47  GLU A OE1 1 
ATOM   352  O  OE2 . GLU A 1 47 ? 4.08743   29.87060 0.30438  1.000 17.17691 ? 47  GLU A OE2 1 
ATOM   353  N  N   . GLU A 1 48 ? 6.38691   23.68216 0.23074  1.000 20.10827 ? 48  GLU A N   1 
ATOM   354  C  CA  . GLU A 1 48 ? 7.34642   22.58618 0.16234  1.000 17.31530 ? 48  GLU A CA  1 
ATOM   355  C  C   . GLU A 1 48 ? 6.68551   21.28607 -0.27463 1.000 22.11311 ? 48  GLU A C   1 
ATOM   356  O  O   . GLU A 1 48 ? 7.31041   20.48486 -0.98017 1.000 22.96673 ? 48  GLU A O   1 
ATOM   357  C  CB  . GLU A 1 48 ? 8.04079   22.41009 1.51125  1.000 20.08690 ? 48  GLU A CB  1 
ATOM   358  C  CG  . GLU A 1 48 ? 8.95028   23.56651 1.87087  1.000 26.08828 ? 48  GLU A CG  1 
ATOM   359  C  CD  . GLU A 1 48 ? 9.26579   23.62822 3.34392  1.000 31.76057 ? 48  GLU A CD  1 
ATOM   360  O  OE1 . GLU A 1 48 ? 8.64940   22.86874 4.11754  1.000 42.05962 ? 48  GLU A OE1 1 
ATOM   361  O  OE2 . GLU A 1 48 ? 10.13383  24.43678 3.73082  1.000 40.01605 ? 48  GLU A OE2 1 
ATOM   362  N  N   . LEU A 1 49 ? 5.43068   21.06169 0.11853  1.000 16.39419 ? 49  LEU A N   1 
ATOM   363  C  CA  . LEU A 1 49 ? 4.72034   19.84483 -0.25416 1.000 21.91189 ? 49  LEU A CA  1 
ATOM   364  C  C   . LEU A 1 49 ? 3.92741   19.98246 -1.54689 1.000 23.41764 ? 49  LEU A C   1 
ATOM   365  O  O   . LEU A 1 49 ? 3.45730   18.96727 -2.07371 1.000 23.64838 ? 49  LEU A O   1 
ATOM   366  C  CB  . LEU A 1 49 ? 3.76824   19.42076 0.86721  1.000 20.67320 ? 49  LEU A CB  1 
ATOM   367  C  CG  . LEU A 1 49 ? 4.36983   18.92754 2.18437  1.000 25.21839 ? 49  LEU A CG  1 
ATOM   368  C  CD1 . LEU A 1 49 ? 3.26206   18.35779 3.05618  1.000 23.99422 ? 49  LEU A CD1 1 
ATOM   369  C  CD2 . LEU A 1 49 ? 5.45977   17.89815 1.95067  1.000 30.80764 ? 49  LEU A CD2 1 
ATOM   370  N  N   . ASP A 1 50 ? 3.78637   21.20418 -2.06821 1.000 20.36352 ? 50  ASP A N   1 
ATOM   371  C  CA  . ASP A 1 50 ? 2.92561   21.50749 -3.21397 1.000 18.77120 ? 50  ASP A CA  1 
ATOM   372  C  C   . ASP A 1 50 ? 1.48637   21.07454 -2.93071 1.000 20.89078 ? 50  ASP A C   1 
ATOM   373  O  O   . ASP A 1 50 ? 0.84411   20.38656 -3.72688 1.000 23.84852 ? 50  ASP A O   1 
ATOM   374  C  CB  . ASP A 1 50 ? 3.46174   20.87386 -4.50270 1.000 20.69930 ? 50  ASP A CB  1 
ATOM   375  C  CG  . ASP A 1 50 ? 2.69980   21.32911 -5.73867 1.000 35.70026 ? 50  ASP A CG  1 
ATOM   376  O  OD1 . ASP A 1 50 ? 1.95586   22.33124 -5.64681 1.000 30.50801 ? 50  ASP A OD1 1 
ATOM   377  O  OD2 . ASP A 1 50 ? 2.84909   20.69079 -6.80087 1.000 38.04968 ? 50  ASP A OD2 1 
ATOM   378  N  N   . VAL A 1 51 ? 0.98389   21.47873 -1.76262 1.000 19.82326 ? 51  VAL A N   1 
ATOM   379  C  CA  . VAL A 1 51 ? -0.38091  21.19601 -1.34415 1.000 18.84673 ? 51  VAL A CA  1 
ATOM   380  C  C   . VAL A 1 51 ? -1.02563  22.49874 -0.88716 1.000 17.82423 ? 51  VAL A C   1 
ATOM   381  O  O   . VAL A 1 51 ? -0.35969  23.51699 -0.70446 1.000 19.27989 ? 51  VAL A O   1 
ATOM   382  C  CB  . VAL A 1 51 ? -0.44751  20.13578 -0.22056 1.000 18.70277 ? 51  VAL A CB  1 
ATOM   383  C  CG1 . VAL A 1 51 ? 0.20437   18.83190 -0.66908 1.000 18.97031 ? 51  VAL A CG1 1 
ATOM   384  C  CG2 . VAL A 1 51 ? 0.22107   20.65298 1.04864  1.000 17.83265 ? 51  VAL A CG2 1 
ATOM   385  N  N   . VAL A 1 52 ? -2.34255  22.45267 -0.70747 1.000 15.21423 ? 52  VAL A N   1 
ATOM   386  C  CA  . VAL A 1 52 ? -3.10913  23.55859 -0.14037 1.000 17.87577 ? 52  VAL A CA  1 
ATOM   387  C  C   . VAL A 1 52 ? -3.85985  23.02046 1.06506  1.000 16.42039 ? 52  VAL A C   1 
ATOM   388  O  O   . VAL A 1 52 ? -4.64773  22.07302 0.93824  1.000 18.05995 ? 52  VAL A O   1 
ATOM   389  C  CB  . VAL A 1 52 ? -4.08357  24.17680 -1.15245 1.000 21.81783 ? 52  VAL A CB  1 
ATOM   390  C  CG1 . VAL A 1 52 ? -4.78218  25.38742 -0.52646 1.000 24.03053 ? 52  VAL A CG1 1 
ATOM   391  C  CG2 . VAL A 1 52 ? -3.35288  24.57218 -2.42750 1.000 25.69951 ? 52  VAL A CG2 1 
ATOM   392  N  N   . LEU A 1 53 ? -3.63092  23.63483 2.22866  1.000 17.55809 ? 53  LEU A N   1 
ATOM   393  C  CA  . LEU A 1 53 ? -4.14212  23.11123 3.48811  1.000 13.32405 ? 53  LEU A CA  1 
ATOM   394  C  C   . LEU A 1 53 ? -5.47169  23.71425 3.90749  1.000 17.64312 ? 53  LEU A C   1 
ATOM   395  O  O   . LEU A 1 53 ? -6.20134  23.08382 4.68051  1.000 18.14294 ? 53  LEU A O   1 
ATOM   396  C  CB  . LEU A 1 53 ? -3.13611  23.35777 4.61413  1.000 16.76298 ? 53  LEU A CB  1 
ATOM   397  C  CG  . LEU A 1 53 ? -1.76044  22.72291 4.45046  1.000 20.41984 ? 53  LEU A CG  1 
ATOM   398  C  CD1 . LEU A 1 53 ? -0.84460  23.20141 5.57768  1.000 22.98499 ? 53  LEU A CD1 1 
ATOM   399  C  CD2 . LEU A 1 53 ? -1.88371  21.22227 4.44980  1.000 16.71176 ? 53  LEU A CD2 1 
ATOM   400  N  N   . PHE A 1 54 ? -5.80308  24.91259 3.43861  1.000 16.25754 ? 54  PHE A N   1 
ATOM   401  C  CA  . PHE A 1 54 ? -6.98307  25.60239 3.92980  1.000 16.16120 ? 54  PHE A CA  1 
ATOM   402  C  C   . PHE A 1 54 ? -7.84926  26.05950 2.76785  1.000 21.98448 ? 54  PHE A C   1 
ATOM   403  O  O   . PHE A 1 54 ? -7.34485  26.41716 1.69757  1.000 21.92199 ? 54  PHE A O   1 
ATOM   404  C  CB  . PHE A 1 54 ? -6.58459  26.78149 4.82321  1.000 19.11643 ? 54  PHE A CB  1 
ATOM   405  C  CG  . PHE A 1 54 ? -5.89553  26.35951 6.09397  1.000 18.22461 ? 54  PHE A CG  1 
ATOM   406  C  CD1 . PHE A 1 54 ? -6.63168  25.97481 7.20427  1.000 16.96093 ? 54  PHE A CD1 1 
ATOM   407  C  CD2 . PHE A 1 54 ? -4.51335  26.32573 6.16802  1.000 20.41929 ? 54  PHE A CD2 1 
ATOM   408  C  CE1 . PHE A 1 54 ? -6.00539  25.57580 8.36815  1.000 18.57517 ? 54  PHE A CE1 1 
ATOM   409  C  CE2 . PHE A 1 54 ? -3.87730  25.93044 7.33171  1.000 19.03415 ? 54  PHE A CE2 1 
ATOM   410  C  CZ  . PHE A 1 54 ? -4.62534  25.55701 8.43600  1.000 21.66155 ? 54  PHE A CZ  1 
ATOM   411  N  N   . ASP A 1 55 ? -9.15898  26.01447 2.98723  1.000 21.47325 ? 55  ASP A N   1 
ATOM   412  C  CA  . ASP A 1 55 ? -10.11309 26.38094 1.95314  1.000 26.98312 ? 55  ASP A CA  1 
ATOM   413  C  C   . ASP A 1 55 ? -10.01830 27.87671 1.68970  1.000 35.67664 ? 55  ASP A C   1 
ATOM   414  O  O   . ASP A 1 55 ? -10.06983 28.68699 2.62027  1.000 41.03796 ? 55  ASP A O   1 
ATOM   415  C  CB  . ASP A 1 55 ? -11.52556 25.98646 2.38617  1.000 29.00313 ? 55  ASP A CB  1 
ATOM   416  C  CG  . ASP A 1 55 ? -12.57084 26.23383 1.30745  1.000 44.65557 ? 55  ASP A CG  1 
ATOM   417  O  OD1 . ASP A 1 55 ? -12.69397 27.37552 0.82343  1.000 50.22313 ? 55  ASP A OD1 1 
ATOM   418  O  OD2 . ASP A 1 55 ? -13.28515 25.27521 0.94860  1.000 55.04086 ? 55  ASP A OD2 1 
ATOM   419  N  N   . ARG A 1 56 ? -9.87082  28.24271 0.41758  1.000 41.45633 ? 56  ARG A N   1 
ATOM   420  C  CA  . ARG A 1 56 ? -9.71652  29.63417 0.02346  1.000 42.18338 ? 56  ARG A CA  1 
ATOM   421  C  C   . ARG A 1 56 ? -11.03917 30.27939 -0.38053 1.000 51.24702 ? 56  ARG A C   1 
ATOM   422  O  O   . ARG A 1 56 ? -11.03757 31.29926 -1.08035 1.000 53.44410 ? 56  ARG A O   1 
ATOM   423  C  CB  . ARG A 1 56 ? -8.67853  29.74012 -1.09519 1.000 42.35451 ? 56  ARG A CB  1 
ATOM   424  C  CG  . ARG A 1 56 ? -7.32584  29.20165 -0.65413 1.000 43.23574 ? 56  ARG A CG  1 
ATOM   425  C  CD  . ARG A 1 56 ? -6.32411  29.07056 -1.78216 1.000 43.21170 ? 56  ARG A CD  1 
ATOM   426  N  NE  . ARG A 1 56 ? -4.96110  29.16201 -1.27086 1.000 39.94739 ? 56  ARG A NE  1 
ATOM   427  C  CZ  . ARG A 1 56 ? -3.87187  28.90642 -1.98213 1.000 39.92718 ? 56  ARG A CZ  1 
ATOM   428  N  NH1 . ARG A 1 56 ? -3.94576  28.54110 -3.25172 1.000 39.50084 ? 56  ARG A NH1 1 
ATOM   429  N  NH2 . ARG A 1 56 ? -2.67885  29.01065 -1.40189 1.000 30.76522 ? 56  ARG A NH2 1 
ATOM   430  N  N   . SER A 1 57 ? -12.16002 29.71061 0.05403  1.000 52.36514 ? 57  SER A N   1 
ATOM   431  C  CA  . SER A 1 57 ? -13.46246 30.35339 -0.06502 1.000 48.53594 ? 57  SER A CA  1 
ATOM   432  C  C   . SER A 1 57 ? -14.19624 30.25482 1.26850  1.000 48.60641 ? 57  SER A C   1 
ATOM   433  O  O   . SER A 1 57 ? -13.62892 29.80535 2.26610  1.000 47.41278 ? 57  SER A O   1 
ATOM   434  C  CB  . SER A 1 57 ? -14.29361 29.71544 -1.17830 1.000 48.91415 ? 57  SER A CB  1 
ATOM   435  O  OG  . SER A 1 57 ? -14.69865 28.40483 -0.82331 1.000 57.87052 ? 57  SER A OG  1 
ATOM   436  N  N   . ARG A 1 60 ? -15.38037 30.89790 7.30926  1.000 50.29929 ? 60  ARG A N   1 
ATOM   437  C  CA  . ARG A 1 60 ? -14.54666 30.55665 8.45758  1.000 55.80098 ? 60  ARG A CA  1 
ATOM   438  C  C   . ARG A 1 60 ? -13.35554 29.70101 8.03594  1.000 38.78603 ? 60  ARG A C   1 
ATOM   439  O  O   . ARG A 1 60 ? -13.33706 29.15228 6.93582  1.000 47.86407 ? 60  ARG A O   1 
ATOM   440  C  CB  . ARG A 1 60 ? -15.36890 29.82487 9.52082  1.000 42.22916 ? 60  ARG A CB  1 
ATOM   441  N  N   . THR A 1 61 ? -12.36486 29.59442 8.91921  1.000 37.93335 ? 61  THR A N   1 
ATOM   442  C  CA  . THR A 1 61 ? -11.17233 28.80387 8.63346  1.000 40.05112 ? 61  THR A CA  1 
ATOM   443  C  C   . THR A 1 61 ? -11.53785 27.32925 8.51907  1.000 32.28993 ? 61  THR A C   1 
ATOM   444  O  O   . THR A 1 61 ? -12.02339 26.72659 9.48212  1.000 30.25502 ? 61  THR A O   1 
ATOM   445  C  CB  . THR A 1 61 ? -10.12198 29.00504 9.72367  1.000 37.82128 ? 61  THR A CB  1 
ATOM   446  O  OG1 . THR A 1 61 ? -9.57909  30.32842 9.63463  1.000 33.98356 ? 61  THR A OG1 1 
ATOM   447  C  CG2 . THR A 1 61 ? -9.00026  27.99261 9.56573  1.000 32.48643 ? 61  THR A CG2 1 
ATOM   448  N  N   . LYS A 1 62 ? -11.28750 26.74771 7.34725  1.000 25.33840 ? 62  LYS A N   1 
ATOM   449  C  CA  . LYS A 1 62 ? -11.67129 25.37704 7.04288  1.000 29.37448 ? 62  LYS A CA  1 
ATOM   450  C  C   . LYS A 1 62 ? -10.48398 24.65535 6.42709  1.000 22.18009 ? 62  LYS A C   1 
ATOM   451  O  O   . LYS A 1 62 ? -9.84382  25.18535 5.51558  1.000 22.91415 ? 62  LYS A O   1 
ATOM   452  C  CB  . LYS A 1 62 ? -12.86014 25.35145 6.07494  1.000 31.82813 ? 62  LYS A CB  1 
ATOM   453  C  CG  . LYS A 1 62 ? -14.22459 25.28269 6.73795  1.000 39.31936 ? 62  LYS A CG  1 
ATOM   454  C  CD  . LYS A 1 62 ? -15.29634 24.82964 5.75415  1.000 45.97602 ? 62  LYS A CD  1 
ATOM   455  C  CE  . LYS A 1 62 ? -14.84992 23.62756 4.93467  1.000 47.76480 ? 62  LYS A CE  1 
ATOM   456  N  NZ  . LYS A 1 62 ? -15.90023 22.57009 4.88738  1.000 56.82090 ? 62  LYS A NZ  1 
ATOM   457  N  N   . PHE A 1 63 ? -10.19367 23.45260 6.91573  1.000 19.76559 ? 63  PHE A N   1 
ATOM   458  C  CA  . PHE A 1 63 ? -9.15257  22.64304 6.29862  1.000 17.21983 ? 63  PHE A CA  1 
ATOM   459  C  C   . PHE A 1 63 ? -9.65102  22.07028 4.97738  1.000 19.03538 ? 63  PHE A C   1 
ATOM   460  O  O   . PHE A 1 63 ? -10.82236 21.70327 4.84846  1.000 17.85878 ? 63  PHE A O   1 
ATOM   461  C  CB  . PHE A 1 63 ? -8.74103  21.49115 7.21446  1.000 17.67480 ? 63  PHE A CB  1 
ATOM   462  C  CG  . PHE A 1 63 ? -7.95282  21.91220 8.41464  1.000 18.50225 ? 63  PHE A CG  1 
ATOM   463  C  CD1 . PHE A 1 63 ? -8.59687  22.37498 9.54965  1.000 19.59809 ? 63  PHE A CD1 1 
ATOM   464  C  CD2 . PHE A 1 63 ? -6.57057  21.82339 8.41879  1.000 20.14998 ? 63  PHE A CD2 1 
ATOM   465  C  CE1 . PHE A 1 63 ? -7.87785  22.75233 10.66477 1.000 20.31606 ? 63  PHE A CE1 1 
ATOM   466  C  CE2 . PHE A 1 63 ? -5.84219  22.19965 9.53646  1.000 21.40914 ? 63  PHE A CE2 1 
ATOM   467  C  CZ  . PHE A 1 63 ? -6.50356  22.66773 10.65887 1.000 18.72079 ? 63  PHE A CZ  1 
ATOM   468  N  N   . THR A 1 64 ? -8.75275  21.98608 3.99800  1.000 15.46302 ? 64  THR A N   1 
ATOM   469  C  CA  . THR A 1 64 ? -9.01525  21.18880 2.80687  1.000 17.63260 ? 64  THR A CA  1 
ATOM   470  C  C   . THR A 1 64 ? -8.96679  19.70411 3.15644  1.000 16.91551 ? 64  THR A C   1 
ATOM   471  O  O   . THR A 1 64 ? -8.56835  19.31421 4.25279  1.000 17.17272 ? 64  THR A O   1 
ATOM   472  C  CB  . THR A 1 64 ? -7.99004  21.47690 1.71280  1.000 18.64878 ? 64  THR A CB  1 
ATOM   473  O  OG1 . THR A 1 64 ? -6.69155  21.08878 2.17284  1.000 19.24755 ? 64  THR A OG1 1 
ATOM   474  C  CG2 . THR A 1 64 ? -7.97408  22.95133 1.35696  1.000 18.37052 ? 64  THR A CG2 1 
ATOM   475  N  N   . ASN A 1 65 ? -9.37421  18.86294 2.20043  1.000 16.78673 ? 65  ASN A N   1 
ATOM   476  C  CA  . ASN A 1 65 ? -9.29898  17.41971 2.42203  1.000 19.77871 ? 65  ASN A CA  1 
ATOM   477  C  C   . ASN A 1 65 ? -7.86040  16.97661 2.66720  1.000 16.36630 ? 65  ASN A C   1 
ATOM   478  O  O   . ASN A 1 65 ? -7.60954  16.07133 3.47299  1.000 16.91674 ? 65  ASN A O   1 
ATOM   479  C  CB  . ASN A 1 65 ? -9.89539  16.67126 1.23052  1.000 23.24008 ? 65  ASN A CB  1 
ATOM   480  C  CG  . ASN A 1 65 ? -11.38198 16.91659 1.07665  1.000 25.68077 ? 65  ASN A CG  1 
ATOM   481  O  OD1 . ASN A 1 65 ? -12.12546 16.93564 2.05660  1.000 26.63633 ? 65  ASN A OD1 1 
ATOM   482  N  ND2 . ASN A 1 65 ? -11.82070 17.11384 -0.15894 1.000 27.10270 ? 65  ASN A ND2 1 
ATOM   483  N  N   . VAL A 1 66 ? -6.90331  17.61045 1.98766  1.000 14.02991 ? 66  VAL A N   1 
ATOM   484  C  CA  . VAL A 1 66 ? -5.49282  17.31236 2.21997  1.000 13.43402 ? 66  VAL A CA  1 
ATOM   485  C  C   . VAL A 1 66 ? -5.05408  17.85727 3.56979  1.000 14.72305 ? 66  VAL A C   1 
ATOM   486  O  O   . VAL A 1 66 ? -4.35274  17.18467 4.33380  1.000 14.51010 ? 66  VAL A O   1 
ATOM   487  C  CB  . VAL A 1 66 ? -4.62557  17.88880 1.08910  1.000 13.76288 ? 66  VAL A CB  1 
ATOM   488  C  CG1 . VAL A 1 66 ? -3.14824  17.77244 1.44922  1.000 15.19335 ? 66  VAL A CG1 1 
ATOM   489  C  CG2 . VAL A 1 66 ? -4.91751  17.17113 -0.22244 1.000 15.90718 ? 66  VAL A CG2 1 
ATOM   490  N  N   . GLY A 1 67 ? -5.42225  19.10296 3.86295  1.000 14.42910 ? 67  GLY A N   1 
ATOM   491  C  CA  . GLY A 1 67 ? -5.13716  19.64155 5.18156  1.000 17.15055 ? 67  GLY A CA  1 
ATOM   492  C  C   . GLY A 1 67 ? -5.72387  18.78472 6.28451  1.000 16.52381 ? 67  GLY A C   1 
ATOM   493  O  O   . GLY A 1 67 ? -5.09794  18.57546 7.32731  1.000 17.42955 ? 67  GLY A O   1 
ATOM   494  N  N   . ARG A 1 68 ? -6.92576  18.25525 6.06198  1.000 14.26572 ? 68  ARG A N   1 
ATOM   495  C  CA  . ARG A 1 68 ? -7.55511  17.46509 7.10692  1.000 14.93191 ? 68  ARG A CA  1 
ATOM   496  C  C   . ARG A 1 68 ? -6.86124  16.12048 7.29267  1.000 14.56801 ? 68  ARG A C   1 
ATOM   497  O  O   . ARG A 1 68 ? -6.78619  15.61485 8.42038  1.000 14.06007 ? 68  ARG A O   1 
ATOM   498  C  CB  . ARG A 1 68 ? -9.03641  17.27440 6.79616  1.000 19.82216 ? 68  ARG A CB  1 
ATOM   499  C  CG  . ARG A 1 68 ? -9.76175  16.41028 7.79354  1.000 25.00076 ? 68  ARG A CG  1 
ATOM   500  C  CD  . ARG A 1 68 ? -11.23621 16.75302 7.77771  1.000 24.85847 ? 68  ARG A CD  1 
ATOM   501  N  NE  . ARG A 1 68 ? -11.52197 18.07384 8.33046  1.000 28.60378 ? 68  ARG A NE  1 
ATOM   502  C  CZ  . ARG A 1 68 ? -11.49942 18.37129 9.62342  1.000 26.10080 ? 68  ARG A CZ  1 
ATOM   503  N  NH1 . ARG A 1 68 ? -11.19956 17.46249 10.53827 1.000 23.36523 ? 68  ARG A NH1 1 
ATOM   504  N  NH2 . ARG A 1 68 ? -11.81309 19.60446 10.01021 1.000 30.99654 ? 68  ARG A NH2 1 
ATOM   505  N  N   . MET A 1 69 ? -6.33949  15.51826 6.22302  1.000 13.90046 ? 69  MET A N   1 
ATOM   506  C  CA  . MET A 1 69 ? -5.64508  14.25523 6.44401  1.000 13.47719 ? 69  MET A CA  1 
ATOM   507  C  C   . MET A 1 69 ? -4.35262  14.49183 7.21927  1.000 13.21185 ? 69  MET A C   1 
ATOM   508  O  O   . MET A 1 69 ? -4.00140  13.70382 8.10416  1.000 15.41085 ? 69  MET A O   1 
ATOM   509  C  CB  . MET A 1 69 ? -5.39766  13.51740 5.12027  1.000 17.22237 ? 69  MET A CB  1 
ATOM   510  C  CG  . MET A 1 69 ? -4.20199  12.56409 5.13986  1.000 14.19335 ? 69  MET A CG  1 
ATOM   511  S  SD  . MET A 1 69 ? -3.69294  11.99629 3.49795  1.000 17.65944 ? 69  MET A SD  1 
ATOM   512  C  CE  . MET A 1 69 ? -5.22022  11.24971 2.91534  1.000 17.35895 ? 69  MET A CE  1 
ATOM   513  N  N   . LEU A 1 70 ? -3.66790  15.60961 6.95746  1.000 14.26213 ? 70  LEU A N   1 
ATOM   514  C  CA  . LEU A 1 70 ? -2.47431  15.93320 7.74151  1.000 13.76377 ? 70  LEU A CA  1 
ATOM   515  C  C   . LEU A 1 70 ? -2.82502  16.24732 9.19419  1.000 14.66960 ? 70  LEU A C   1 
ATOM   516  O  O   . LEU A 1 70 ? -2.12353  15.81115 10.11948 1.000 14.02505 ? 70  LEU A O   1 
ATOM   517  C  CB  . LEU A 1 70 ? -1.72954  17.10386 7.09696  1.000 14.05048 ? 70  LEU A CB  1 
ATOM   518  C  CG  . LEU A 1 70 ? -0.98128  16.75031 5.80840  1.000 16.86619 ? 70  LEU A CG  1 
ATOM   519  C  CD1 . LEU A 1 70 ? -0.52135  17.99619 5.09246  1.000 20.99055 ? 70  LEU A CD1 1 
ATOM   520  C  CD2 . LEU A 1 70 ? 0.21021   15.85033 6.11043  1.000 14.28165 ? 70  LEU A CD2 1 
ATOM   521  N  N   . LEU A 1 71 ? -3.89700  17.01141 9.41461  1.000 13.30488 ? 71  LEU A N   1 
ATOM   522  C  CA  . LEU A 1 71 ? -4.34808  17.30183 10.77304 1.000 12.98411 ? 71  LEU A CA  1 
ATOM   523  C  C   . LEU A 1 71 ? -4.63246  16.02009 11.54809 1.000 14.73232 ? 71  LEU A C   1 
ATOM   524  O  O   . LEU A 1 71 ? -4.06101  15.78556 12.61991 1.000 14.63548 ? 71  LEU A O   1 
ATOM   525  C  CB  . LEU A 1 71 ? -5.60230  18.17747 10.72290 1.000 15.27781 ? 71  LEU A CB  1 
ATOM   526  C  CG  . LEU A 1 71 ? -6.39230  18.28185 12.02857 1.000 14.18729 ? 71  LEU A CG  1 
ATOM   527  C  CD1 . LEU A 1 71 ? -5.59774  19.07922 13.03782 1.000 14.23169 ? 71  LEU A CD1 1 
ATOM   528  C  CD2 . LEU A 1 71 ? -7.74688  18.92709 11.77899 1.000 19.49505 ? 71  LEU A CD2 1 
ATOM   529  N  N   . GLU A 1 72 ? -5.50427  15.16742 11.00460 1.000 13.51285 ? 72  GLU A N   1 
ATOM   530  C  CA  . GLU A 1 72 ? -6.02535  14.03513 11.76660 1.000 14.50012 ? 72  GLU A CA  1 
ATOM   531  C  C   . GLU A 1 72 ? -4.97036  12.95203 11.95701 1.000 13.88500 ? 72  GLU A C   1 
ATOM   532  O  O   . GLU A 1 72 ? -4.72284  12.50588 13.08195 1.000 17.98110 ? 72  GLU A O   1 
ATOM   533  C  CB  . GLU A 1 72 ? -7.26468  13.46996 11.07035 1.000 14.18594 ? 72  GLU A CB  1 
ATOM   534  C  CG  . GLU A 1 72 ? -8.41839  14.43589 11.05224 1.000 13.01073 ? 72  GLU A CG  1 
ATOM   535  C  CD  . GLU A 1 72 ? -9.65029  13.90704 10.32841 1.000 18.67676 ? 72  GLU A CD  1 
ATOM   536  O  OE1 . GLU A 1 72 ? -9.65514  12.74443 9.87470  1.000 20.78009 ? 72  GLU A OE1 1 
ATOM   537  O  OE2 . GLU A 1 72 ? -10.62936 14.66568 10.22888 1.000 20.22400 ? 72  GLU A OE2 1 
ATOM   538  N  N   . ARG A 1 73 ? -4.35423  12.49324 10.86840 1.000 14.78069 ? 73  ARG A N   1 
ATOM   539  C  CA  A ARG A 1 73 ? -3.30426  11.49356 11.00308 0.506 15.65356 ? 73  ARG A CA  1 
ATOM   540  C  CA  B ARG A 1 73 ? -3.29631  11.49811 10.98523 0.494 15.78870 ? 73  ARG A CA  1 
ATOM   541  C  C   . ARG A 1 73 ? -2.05027  12.07285 11.64230 1.000 15.66726 ? 73  ARG A C   1 
ATOM   542  O  O   . ARG A 1 73 ? -1.25097  11.31585 12.20181 1.000 17.08713 ? 73  ARG A O   1 
ATOM   543  C  CB  A ARG A 1 73 ? -2.98742  10.88085 9.63830  0.506 16.20759 ? 73  ARG A CB  1 
ATOM   544  C  CB  B ARG A 1 73 ? -2.96024  10.92922 9.60559  0.494 16.38425 ? 73  ARG A CB  1 
ATOM   545  C  CG  A ARG A 1 73 ? -4.23968  10.44840 8.88897  0.506 17.66911 ? 73  ARG A CG  1 
ATOM   546  C  CG  B ARG A 1 73 ? -4.18934  10.48510 8.82567  0.494 18.59453 ? 73  ARG A CG  1 
ATOM   547  C  CD  A ARG A 1 73 ? -3.93422  9.63916  7.63998  0.506 20.43680 ? 73  ARG A CD  1 
ATOM   548  C  CD  B ARG A 1 73 ? -3.83337  9.60918  7.63545  0.494 20.43812 ? 73  ARG A CD  1 
ATOM   549  N  NE  A ARG A 1 73 ? -2.59438  9.06611  7.63928  0.506 21.76017 ? 73  ARG A NE  1 
ATOM   550  N  NE  B ARG A 1 73 ? -5.01893  9.27089  6.85630  0.494 15.77481 ? 73  ARG A NE  1 
ATOM   551  C  CZ  A ARG A 1 73 ? -1.99036  8.60211  6.55381  0.506 20.36994 ? 73  ARG A CZ  1 
ATOM   552  C  CZ  B ARG A 1 73 ? -5.01017  8.53496  5.75381  0.494 21.18446 ? 73  ARG A CZ  1 
ATOM   553  N  NH1 A ARG A 1 73 ? -2.57792  8.63839  5.37046  0.506 20.54082 ? 73  ARG A NH1 1 
ATOM   554  N  NH1 B ARG A 1 73 ? -3.88790  8.03058  5.26768  0.494 16.38974 ? 73  ARG A NH1 1 
ATOM   555  N  NH2 A ARG A 1 73 ? -0.77167  8.08334  6.65976  0.506 15.32547 ? 73  ARG A NH2 1 
ATOM   556  N  NH2 B ARG A 1 73 ? -6.15736  8.29452  5.12619  0.494 19.54478 ? 73  ARG A NH2 1 
ATOM   557  N  N   . GLY A 1 74 ? -1.87529  13.39510 11.59145 1.000 13.82981 ? 74  GLY A N   1 
ATOM   558  C  CA  . GLY A 1 74 ? -0.76020  14.01520 12.28330 1.000 14.43857 ? 74  GLY A CA  1 
ATOM   559  C  C   . GLY A 1 74 ? -0.91972  13.98494 13.78939 1.000 15.52872 ? 74  GLY A C   1 
ATOM   560  O  O   . GLY A 1 74 ? 0.07089   13.96555 14.51978 1.000 15.00466 ? 74  GLY A O   1 
ATOM   561  N  N   . ARG A 1 75 ? -2.16148  13.96605 14.27722 1.000 13.65084 ? 75  ARG A N   1 
ATOM   562  C  CA  . ARG A 1 75 ? -2.36763  13.83724 15.71511 1.000 15.04568 ? 75  ARG A CA  1 
ATOM   563  C  C   . ARG A 1 75 ? -1.90292  12.47891 16.22178 1.000 18.19257 ? 75  ARG A C   1 
ATOM   564  O  O   . ARG A 1 75 ? -1.43864  12.37268 17.36294 1.000 16.74418 ? 75  ARG A O   1 
ATOM   565  C  CB  . ARG A 1 75 ? -3.83571  14.06223 16.06914 1.000 14.14513 ? 75  ARG A CB  1 
ATOM   566  C  CG  . ARG A 1 75 ? -4.24657  15.52210 16.07943 1.000 13.49058 ? 75  ARG A CG  1 
ATOM   567  C  CD  . ARG A 1 75 ? -5.74910  15.65804 16.06144 1.000 13.89700 ? 75  ARG A CD  1 
ATOM   568  N  NE  . ARG A 1 75 ? -6.16935  17.01918 16.36358 1.000 15.73481 ? 75  ARG A NE  1 
ATOM   569  C  CZ  . ARG A 1 75 ? -7.29102  17.56565 15.92129 1.000 14.60535 ? 75  ARG A CZ  1 
ATOM   570  N  NH1 . ARG A 1 75 ? -8.14587  16.87965 15.18199 1.000 13.79518 ? 75  ARG A NH1 1 
ATOM   571  N  NH2 . ARG A 1 75 ? -7.56635  18.82767 16.23787 1.000 13.14546 ? 75  ARG A NH2 1 
ATOM   572  N  N   . VAL A 1 76 ? -2.01211  11.43774 15.39087 1.000 16.56800 ? 76  VAL A N   1 
ATOM   573  C  CA  . VAL A 1 76 ? -1.46199  10.13406 15.75482 1.000 17.45103 ? 76  VAL A CA  1 
ATOM   574  C  C   . VAL A 1 76 ? 0.04352   10.23544 15.94421 1.000 16.39514 ? 76  VAL A C   1 
ATOM   575  O  O   . VAL A 1 76 ? 0.60671   9.66804  16.89139 1.000 17.50670 ? 76  VAL A O   1 
ATOM   576  C  CB  . VAL A 1 76 ? -1.81921  9.07810  14.69257 1.000 19.04704 ? 76  VAL A CB  1 
ATOM   577  C  CG1 . VAL A 1 76 ? -1.24274  7.71730  15.08298 1.000 18.51096 ? 76  VAL A CG1 1 
ATOM   578  C  CG2 . VAL A 1 76 ? -3.32550  9.00010  14.50292 1.000 20.25106 ? 76  VAL A CG2 1 
ATOM   579  N  N   . LEU A 1 77 ? 0.71736   10.95245 15.03853 1.000 14.42443 ? 77  LEU A N   1 
ATOM   580  C  CA  . LEU A 1 77 ? 2.15156   11.18087 15.17758 1.000 17.10917 ? 77  LEU A CA  1 
ATOM   581  C  C   . LEU A 1 77 ? 2.46040   11.97510 16.43706 1.000 15.20032 ? 77  LEU A C   1 
ATOM   582  O  O   . LEU A 1 77 ? 3.41615   11.66428 17.15703 1.000 15.98034 ? 77  LEU A O   1 
ATOM   583  C  CB  . LEU A 1 77 ? 2.69250   11.91247 13.94808 1.000 18.10702 ? 77  LEU A CB  1 
ATOM   584  C  CG  . LEU A 1 77 ? 3.49605   11.07055 12.96405 1.000 31.58000 ? 77  LEU A CG  1 
ATOM   585  C  CD1 . LEU A 1 77 ? 4.78091   10.59247 13.61446 1.000 28.01891 ? 77  LEU A CD1 1 
ATOM   586  C  CD2 . LEU A 1 77 ? 2.66669   9.89638  12.48863 1.000 25.55515 ? 77  LEU A CD2 1 
ATOM   587  N  N   . LEU A 1 78 ? 1.67460   13.01950 16.70913 1.000 12.66155 ? 78  LEU A N   1 
ATOM   588  C  CA  . LEU A 1 78 ? 1.90554   13.81377 17.91033 1.000 14.54928 ? 78  LEU A CA  1 
ATOM   589  C  C   . LEU A 1 78 ? 1.77776   12.96067 19.16541 1.000 18.30473 ? 78  LEU A C   1 
ATOM   590  O  O   . LEU A 1 78 ? 2.56551   13.10672 20.10610 1.000 15.93192 ? 78  LEU A O   1 
ATOM   591  C  CB  . LEU A 1 78 ? 0.93027   14.99017 17.96381 1.000 15.16520 ? 78  LEU A CB  1 
ATOM   592  C  CG  . LEU A 1 78 ? 1.18506   16.09032 16.94033 1.000 17.35999 ? 78  LEU A CG  1 
ATOM   593  C  CD1 . LEU A 1 78 ? 0.15970   17.20575 17.08134 1.000 17.96251 ? 78  LEU A CD1 1 
ATOM   594  C  CD2 . LEU A 1 78 ? 2.59945   16.62107 17.09384 1.000 18.21531 ? 78  LEU A CD2 1 
ATOM   595  N  N   . GLU A 1 79 ? 0.79316   12.06081 19.19762 1.000 17.71461 ? 79  GLU A N   1 
ATOM   596  C  CA  . GLU A 1 79 ? 0.62198   11.20559 20.36838 1.000 17.88550 ? 79  GLU A CA  1 
ATOM   597  C  C   . GLU A 1 79 ? 1.80030   10.24972 20.52121 1.000 17.87031 ? 79  GLU A C   1 
ATOM   598  O  O   . GLU A 1 79 ? 2.29574   10.03300 21.63213 1.000 17.31176 ? 79  GLU A O   1 
ATOM   599  C  CB  . GLU A 1 79 ? -0.70391  10.44196 20.26776 1.000 18.48929 ? 79  GLU A CB  1 
ATOM   600  C  CG  . GLU A 1 79 ? -0.75597  9.12831  21.04912 1.000 26.55484 ? 79  GLU A CG  1 
ATOM   601  C  CD  . GLU A 1 79 ? -2.17096  8.57696  21.19289 1.000 39.65963 ? 79  GLU A CD  1 
ATOM   602  O  OE1 . GLU A 1 79 ? -2.94535  8.64492  20.21420 1.000 39.18471 ? 79  GLU A OE1 1 
ATOM   603  O  OE2 . GLU A 1 79 ? -2.50638  8.05881  22.28051 1.000 42.38844 ? 79  GLU A OE2 1 
ATOM   604  N  N   . ALA A 1 80 ? 2.28605   9.69402  19.41263 1.000 16.53437 ? 80  ALA A N   1 
ATOM   605  C  CA  . ALA A 1 80 ? 3.42142   8.78637  19.49300 1.000 16.88986 ? 80  ALA A CA  1 
ATOM   606  C  C   . ALA A 1 80 ? 4.70395   9.51879  19.87277 1.000 16.51323 ? 80  ALA A C   1 
ATOM   607  O  O   . ALA A 1 80 ? 5.56336   8.94632  20.55496 1.000 13.74955 ? 80  ALA A O   1 
ATOM   608  C  CB  . ALA A 1 80 ? 3.58330   8.04987  18.16551 1.000 19.27900 ? 80  ALA A CB  1 
ATOM   609  N  N   . ALA A 1 81 ? 4.85118   10.77937 19.45627 1.000 15.10407 ? 81  ALA A N   1 
ATOM   610  C  CA  . ALA A 1 81 ? 6.01823   11.54903 19.87662 1.000 16.05452 ? 81  ALA A CA  1 
ATOM   611  C  C   . ALA A 1 81 ? 5.96471   11.86090 21.36744 1.000 17.51428 ? 81  ALA A C   1 
ATOM   612  O  O   . ALA A 1 81 ? 6.99204   11.81242 22.05464 1.000 15.65475 ? 81  ALA A O   1 
ATOM   613  C  CB  . ALA A 1 81 ? 6.12997   12.83721 19.06221 1.000 16.04597 ? 81  ALA A CB  1 
ATOM   614  N  N   . ASP A 1 82 ? 4.78044   12.19279 21.88664 1.000 16.06135 ? 82  ASP A N   1 
ATOM   615  C  CA  . ASP A 1 82 ? 4.64638   12.41279 23.32572 1.000 16.16722 ? 82  ASP A CA  1 
ATOM   616  C  C   . ASP A 1 82 ? 4.90696   11.12860 24.10138 1.000 16.78738 ? 82  ASP A C   1 
ATOM   617  O  O   . ASP A 1 82 ? 5.56920   11.14704 25.14641 1.000 18.00612 ? 82  ASP A O   1 
ATOM   618  C  CB  . ASP A 1 82 ? 3.25487   12.95233 23.65835 1.000 19.94665 ? 82  ASP A CB  1 
ATOM   619  C  CG  . ASP A 1 82 ? 2.95169   14.26518 22.96211 1.000 32.48333 ? 82  ASP A CG  1 
ATOM   620  O  OD1 . ASP A 1 82 ? 3.82123   14.76688 22.21763 1.000 40.80000 ? 82  ASP A OD1 1 
ATOM   621  O  OD2 . ASP A 1 82 ? 1.84032   14.79660 23.16191 1.000 35.80784 ? 82  ASP A OD2 1 
ATOM   622  N  N   . LYS A 1 83 ? 4.38492   10.00332 23.60592 1.000 16.67323 ? 83  LYS A N   1 
ATOM   623  C  CA  . LYS A 1 83 ? 4.60189   8.71995  24.26761 1.000 16.80329 ? 83  LYS A CA  1 
ATOM   624  C  C   . LYS A 1 83 ? 6.07967   8.36324  24.30943 1.000 19.84586 ? 83  LYS A C   1 
ATOM   625  O  O   . LYS A 1 83 ? 6.58074   7.85793  25.32256 1.000 15.82792 ? 83  LYS A O   1 
ATOM   626  C  CB  . LYS A 1 83 ? 3.81474   7.62410  23.55145 1.000 20.24882 ? 83  LYS A CB  1 
ATOM   627  C  CG  . LYS A 1 83 ? 4.02275   6.23452  24.11838 1.000 21.65279 ? 83  LYS A CG  1 
ATOM   628  C  CD  . LYS A 1 83 ? 3.02888   5.24290  23.53907 1.000 32.30221 ? 83  LYS A CD  1 
ATOM   629  C  CE  . LYS A 1 83 ? 3.37526   3.81424  23.93713 1.000 47.35227 ? 83  LYS A CE  1 
ATOM   630  N  NZ  . LYS A 1 83 ? 3.53795   3.66654  25.41156 1.000 44.84866 ? 83  LYS A NZ  1 
ATOM   631  N  N   . LEU A 1 84 ? 6.79285   8.60898  23.21327 1.000 16.14684 ? 84  LEU A N   1 
ATOM   632  C  CA  . LEU A 1 84 ? 8.21697   8.30486  23.19466 1.000 16.56351 ? 84  LEU A CA  1 
ATOM   633  C  C   . LEU A 1 84 ? 8.97231   9.20008  24.16656 1.000 16.24639 ? 84  LEU A C   1 
ATOM   634  O  O   . LEU A 1 84 ? 9.90145   8.74573  24.84556 1.000 14.57429 ? 84  LEU A O   1 
ATOM   635  C  CB  . LEU A 1 84 ? 8.75688   8.45272  21.77012 1.000 16.14015 ? 84  LEU A CB  1 
ATOM   636  C  CG  . LEU A 1 84 ? 10.26768  8.32868  21.59269 1.000 17.47646 ? 84  LEU A CG  1 
ATOM   637  C  CD1 . LEU A 1 84 ? 10.74514  7.01037  22.19095 1.000 14.90111 ? 84  LEU A CD1 1 
ATOM   638  C  CD2 . LEU A 1 84 ? 10.64512  8.42452  20.11714 1.000 17.15721 ? 84  LEU A CD2 1 
ATOM   639  N  N   . THR A 1 85 ? 8.58485   10.47642 24.24817 1.000 15.72311 ? 85  THR A N   1 
ATOM   640  C  CA  . THR A 1 85 ? 9.19470   11.37943 25.22000 1.000 14.38953 ? 85  THR A CA  1 
ATOM   641  C  C   . THR A 1 85 ? 8.97190   10.88000 26.64272 1.000 16.05419 ? 85  THR A C   1 
ATOM   642  O  O   . THR A 1 85 ? 9.90701   10.82619 27.44882 1.000 15.71657 ? 85  THR A O   1 
ATOM   643  C  CB  . THR A 1 85 ? 8.62537   12.79062 25.06340 1.000 20.48541 ? 85  THR A CB  1 
ATOM   644  O  OG1 . THR A 1 85 ? 8.85556   13.26436 23.73383 1.000 15.80791 ? 85  THR A OG1 1 
ATOM   645  C  CG2 . THR A 1 85 ? 9.28334   13.74344 26.05997 1.000 18.73283 ? 85  THR A CG2 1 
ATOM   646  N  N   . THR A 1 86 ? 7.73261   10.50448 26.96542 1.000 15.94487 ? 86  THR A N   1 
ATOM   647  C  CA  . THR A 1 86 ? 7.42725   9.99593  28.30053 1.000 13.90700 ? 86  THR A CA  1 
ATOM   648  C  C   . THR A 1 86 ? 8.19900   8.71677  28.60377 1.000 18.41145 ? 86  THR A C   1 
ATOM   649  O  O   . THR A 1 86 ? 8.74309   8.55631  29.70414 1.000 18.00159 ? 86  THR A O   1 
ATOM   650  C  CB  . THR A 1 86 ? 5.92444   9.75104  28.43154 1.000 21.70800 ? 86  THR A CB  1 
ATOM   651  O  OG1 . THR A 1 86 ? 5.21660   10.96950 28.17195 1.000 23.31873 ? 86  THR A OG1 1 
ATOM   652  C  CG2 . THR A 1 86 ? 5.58358   9.26205  29.83257 1.000 24.68854 ? 86  THR A CG2 1 
ATOM   653  N  N   . ASP A 1 87 ? 8.25195   7.79023  27.64418 1.000 14.84368 ? 87  ASP A N   1 
ATOM   654  C  CA  . ASP A 1 87 ? 8.95513   6.52937  27.86923 1.000 14.42538 ? 87  ASP A CA  1 
ATOM   655  C  C   . ASP A 1 87 ? 10.45037  6.75593  28.05002 1.000 16.42827 ? 87  ASP A C   1 
ATOM   656  O  O   . ASP A 1 87 ? 11.08414  6.12353  28.90709 1.000 15.77788 ? 87  ASP A O   1 
ATOM   657  C  CB  . ASP A 1 87 ? 8.69829   5.56928  26.70713 1.000 15.71284 ? 87  ASP A CB  1 
ATOM   658  C  CG  . ASP A 1 87 ? 7.26414   5.08252  26.65493 1.000 21.50255 ? 87  ASP A CG  1 
ATOM   659  O  OD1 . ASP A 1 87 ? 6.51586   5.30881  27.62833 1.000 21.05229 ? 87  ASP A OD1 1 
ATOM   660  O  OD2 . ASP A 1 87 ? 6.88384   4.47666  25.63389 1.000 20.13943 ? 87  ASP A OD2 1 
ATOM   661  N  N   . ALA A 1 88 ? 11.03329  7.65164  27.25113 1.000 15.62759 ? 88  ALA A N   1 
ATOM   662  C  CA  . ALA A 1 88 ? 12.45183  7.95714  27.39996 1.000 17.22307 ? 88  ALA A CA  1 
ATOM   663  C  C   . ALA A 1 88 ? 12.73870  8.58257  28.75697 1.000 17.59821 ? 88  ALA A C   1 
ATOM   664  O  O   . ALA A 1 88 ? 13.72808  8.23345  29.41565 1.000 17.91518 ? 88  ALA A O   1 
ATOM   665  C  CB  . ALA A 1 88 ? 12.91037  8.88236  26.27788 1.000 16.47217 ? 88  ALA A CB  1 
ATOM   666  N  N   . GLU A 1 89 ? 11.88684  9.51524  29.18910 1.000 16.48808 ? 89  GLU A N   1 
ATOM   667  C  CA  A GLU A 1 89 ? 12.06092  10.12796 30.50204 0.514 19.18364 ? 89  GLU A CA  1 
ATOM   668  C  CA  B GLU A 1 89 ? 12.06793  10.12372 30.50324 0.486 19.08700 ? 89  GLU A CA  1 
ATOM   669  C  C   . GLU A 1 89 ? 11.92470  9.09642  31.61535 1.000 20.77125 ? 89  GLU A C   1 
ATOM   670  O  O   . GLU A 1 89 ? 12.66647  9.13722  32.60435 1.000 20.88422 ? 89  GLU A O   1 
ATOM   671  C  CB  A GLU A 1 89 ? 11.04769  11.26105 30.68494 0.514 22.35663 ? 89  GLU A CB  1 
ATOM   672  C  CB  B GLU A 1 89 ? 11.06701  11.25925 30.70506 0.486 22.36183 ? 89  GLU A CB  1 
ATOM   673  C  CG  A GLU A 1 89 ? 11.33830  12.48738 29.82729 0.514 23.22976 ? 89  GLU A CG  1 
ATOM   674  C  CG  B GLU A 1 89 ? 11.34645  12.48241 29.86463 0.486 23.23054 ? 89  GLU A CG  1 
ATOM   675  C  CD  A GLU A 1 89 ? 10.17713  13.47340 29.76787 0.514 26.71620 ? 89  GLU A CD  1 
ATOM   676  C  CD  B GLU A 1 89 ? 12.63417  13.17862 30.25055 0.486 25.71777 ? 89  GLU A CD  1 
ATOM   677  O  OE1 A GLU A 1 89 ? 9.04505   13.10650 30.15190 0.514 21.84072 ? 89  GLU A OE1 1 
ATOM   678  O  OE1 B GLU A 1 89 ? 13.15040  12.94578 31.36626 0.486 27.15388 ? 89  GLU A OE1 1 
ATOM   679  O  OE2 A GLU A 1 89 ? 10.40187  14.61944 29.32494 0.514 30.60462 ? 89  GLU A OE2 1 
ATOM   680  O  OE2 B GLU A 1 89 ? 13.13155  13.96916 29.42841 0.486 31.14354 ? 89  GLU A OE2 1 
ATOM   681  N  N   . ALA A 1 90 ? 10.98138  8.16559  31.47314 1.000 16.20882 ? 90  ALA A N   1 
ATOM   682  C  CA  . ALA A 1 90 ? 10.77922  7.16324  32.51240 1.000 18.85176 ? 90  ALA A CA  1 
ATOM   683  C  C   . ALA A 1 90 ? 11.98142  6.23501  32.62353 1.000 19.61365 ? 90  ALA A C   1 
ATOM   684  O  O   . ALA A 1 90 ? 12.40737  5.89590  33.73376 1.000 18.17010 ? 90  ALA A O   1 
ATOM   685  C  CB  . ALA A 1 90 ? 9.50440   6.36734  32.23493 1.000 20.71841 ? 90  ALA A CB  1 
ATOM   686  N  N   . LEU A 1 91 ? 12.53991  5.80993  31.48628 1.000 16.99387 ? 91  LEU A N   1 
ATOM   687  C  CA  . LEU A 1 91 ? 13.74988  4.99155  31.52014 1.000 17.00596 ? 91  LEU A CA  1 
ATOM   688  C  C   . LEU A 1 91 ? 14.90367  5.75398  32.15530 1.000 18.02839 ? 91  LEU A C   1 
ATOM   689  O  O   . LEU A 1 91 ? 15.66343  5.19431  32.95588 1.000 16.53053 ? 91  LEU A O   1 
ATOM   690  C  CB  . LEU A 1 91 ? 14.12669  4.53554  30.10671 1.000 13.59810 ? 91  LEU A CB  1 
ATOM   691  C  CG  . LEU A 1 91 ? 15.44627  3.76823  29.97235 1.000 13.57987 ? 91  LEU A CG  1 
ATOM   692  C  CD1 . LEU A 1 91 ? 15.48758  2.55357  30.89585 1.000 13.47809 ? 91  LEU A CD1 1 
ATOM   693  C  CD2 . LEU A 1 91 ? 15.72105  3.35234  28.53066 1.000 13.44679 ? 91  LEU A CD2 1 
ATOM   694  N  N   . ALA A 1 92 ? 15.04618  7.03654  31.81299 1.000 16.37243 ? 92  ALA A N   1 
ATOM   695  C  CA  . ALA A 1 92 ? 16.10856  7.84774  32.39753 1.000 17.42976 ? 92  ALA A CA  1 
ATOM   696  C  C   . ALA A 1 92 ? 15.99943  7.89343  33.91713 1.000 21.16735 ? 92  ALA A C   1 
ATOM   697  O  O   . ALA A 1 92 ? 17.01499  7.83170  34.61980 1.000 20.08827 ? 92  ALA A O   1 
ATOM   698  C  CB  . ALA A 1 92 ? 16.06972  9.25942  31.81409 1.000 18.63161 ? 92  ALA A CB  1 
ATOM   699  N  N   . ARG A 1 93 ? 14.77527  7.98734  34.44532 1.000 20.58698 ? 93  ARG A N   1 
ATOM   700  C  CA  A ARG A 1 93 ? 14.59510  8.03096  35.89471 0.526 18.47427 ? 93  ARG A CA  1 
ATOM   701  C  CA  B ARG A 1 93 ? 14.61470  8.03632  35.89537 0.474 18.48866 ? 93  ARG A CA  1 
ATOM   702  C  C   . ARG A 1 93 ? 14.98361  6.70629  36.54143 1.000 20.17693 ? 93  ARG A C   1 
ATOM   703  O  O   . ARG A 1 93 ? 15.63706  6.68736  37.59109 1.000 20.69152 ? 93  ARG A O   1 
ATOM   704  C  CB  A ARG A 1 93 ? 13.14806  8.39768  36.23725 0.526 25.53528 ? 93  ARG A CB  1 
ATOM   705  C  CB  B ARG A 1 93 ? 13.18815  8.45127  36.25735 0.474 25.55227 ? 93  ARG A CB  1 
ATOM   706  C  CG  A ARG A 1 93 ? 12.81998  9.87285  36.02954 0.526 29.35558 ? 93  ARG A CG  1 
ATOM   707  C  CG  B ARG A 1 93 ? 12.76759  9.73428  35.56694 0.474 27.81691 ? 93  ARG A CG  1 
ATOM   708  C  CD  A ARG A 1 93 ? 11.40944  10.24572 36.49555 0.526 34.03679 ? 93  ARG A CD  1 
ATOM   709  C  CD  B ARG A 1 93 ? 11.70918  10.52424 36.31758 0.474 34.85888 ? 93  ARG A CD  1 
ATOM   710  N  NE  A ARG A 1 93 ? 10.46423  9.13549  36.44483 0.526 29.75350 ? 93  ARG A NE  1 
ATOM   711  N  NE  B ARG A 1 93 ? 11.58309  11.86583 35.75773 0.474 35.50717 ? 93  ARG A NE  1 
ATOM   712  C  CZ  A ARG A 1 93 ? 9.55796   8.96121  35.49165 0.526 24.76066 ? 93  ARG A CZ  1 
ATOM   713  C  CZ  B ARG A 1 93 ? 10.81849  12.17729 34.72011 0.474 30.21961 ? 93  ARG A CZ  1 
ATOM   714  N  NH1 A ARG A 1 93 ? 9.44266   9.80913  34.48183 0.526 20.38431 ? 93  ARG A NH1 1 
ATOM   715  N  NH1 B ARG A 1 93 ? 10.07700  11.26724 34.11016 0.474 25.41484 ? 93  ARG A NH1 1 
ATOM   716  N  NH2 A ARG A 1 93 ? 8.74168   7.91368  35.55713 0.526 21.18323 ? 93  ARG A NH2 1 
ATOM   717  N  NH2 B ARG A 1 93 ? 10.80029  13.43265 34.28102 0.474 34.40467 ? 93  ARG A NH2 1 
ATOM   718  N  N   . LEU A 1 94 ? 14.59400  5.58318  35.92869 1.000 18.89645 ? 94  LEU A N   1 
ATOM   719  C  CA  . LEU A 1 94 ? 14.98377  4.28610  36.47384 1.000 18.54609 ? 94  LEU A CA  1 
ATOM   720  C  C   . LEU A 1 94 ? 16.48663  4.05464  36.40121 1.000 21.95466 ? 94  LEU A C   1 
ATOM   721  O  O   . LEU A 1 94 ? 17.00509  3.20249  37.12959 1.000 19.85219 ? 94  LEU A O   1 
ATOM   722  C  CB  . LEU A 1 94 ? 14.26447  3.14943  35.74893 1.000 17.97938 ? 94  LEU A CB  1 
ATOM   723  C  CG  . LEU A 1 94 ? 12.74654  3.07341  35.91170 1.000 22.71312 ? 94  LEU A CG  1 
ATOM   724  C  CD1 . LEU A 1 94 ? 12.16201  1.98174  35.02158 1.000 23.64026 ? 94  LEU A CD1 1 
ATOM   725  C  CD2 . LEU A 1 94 ? 12.36791  2.85343  37.37289 1.000 20.29941 ? 94  LEU A CD2 1 
ATOM   726  N  N   . GLU A 1 95 ? 17.19003  4.77137  35.52951 1.000 19.49232 ? 95  GLU A N   1 
ATOM   727  C  CA  . GLU A 1 95 ? 18.63901  4.67550  35.43938 1.000 18.15991 ? 95  GLU A CA  1 
ATOM   728  C  C   . GLU A 1 95 ? 19.34685  5.75115  36.24440 1.000 18.37294 ? 95  GLU A C   1 
ATOM   729  O  O   . GLU A 1 95 ? 20.58128  5.78998  36.24269 1.000 21.43062 ? 95  GLU A O   1 
ATOM   730  C  CB  . GLU A 1 95 ? 19.08412  4.75103  33.97936 1.000 15.69739 ? 95  GLU A CB  1 
ATOM   731  C  CG  . GLU A 1 95 ? 18.59085  3.58485  33.13879 1.000 15.93886 ? 95  GLU A CG  1 
ATOM   732  C  CD  . GLU A 1 95 ? 19.10485  3.64602  31.72420 1.000 20.57951 ? 95  GLU A CD  1 
ATOM   733  O  OE1 . GLU A 1 95 ? 19.35625  4.76839  31.23868 1.000 21.51017 ? 95  GLU A OE1 1 
ATOM   734  O  OE2 . GLU A 1 95 ? 19.26459  2.57736  31.10490 1.000 20.68334 ? 95  GLU A OE2 1 
ATOM   735  N  N   . HIS A 1 96 ? 18.59700  6.61536  36.92405 1.000 19.48161 ? 96  HIS A N   1 
ATOM   736  C  CA  . HIS A 1 96 ? 19.15721  7.68371  37.74282 1.000 20.85866 ? 96  HIS A CA  1 
ATOM   737  C  C   . HIS A 1 96 ? 20.11290  8.54109  36.91549 1.000 26.60563 ? 96  HIS A C   1 
ATOM   738  O  O   . HIS A 1 96 ? 21.29018  8.71966  37.23778 1.000 27.31494 ? 96  HIS A O   1 
ATOM   739  C  CB  . HIS A 1 96 ? 19.83206  7.10426  38.98568 1.000 20.61302 ? 96  HIS A CB  1 
ATOM   740  C  CG  . HIS A 1 96 ? 18.91919  6.25538  39.81311 1.000 19.77808 ? 96  HIS A CG  1 
ATOM   741  N  ND1 . HIS A 1 96 ? 17.91081  6.78748  40.58623 1.000 21.03895 ? 96  HIS A ND1 1 
ATOM   742  C  CD2 . HIS A 1 96 ? 18.85148  4.91357  39.97978 1.000 18.93460 ? 96  HIS A CD2 1 
ATOM   743  C  CE1 . HIS A 1 96 ? 17.26514  5.81191  41.19851 1.000 18.97690 ? 96  HIS A CE1 1 
ATOM   744  N  NE2 . HIS A 1 96 ? 17.81489  4.66521  40.84530 1.000 20.62223 ? 96  HIS A NE2 1 
ATOM   745  N  N   . HIS A 1 97 ? 19.56717  9.05643  35.81625 1.000 21.51089 ? 97  HIS A N   1 
ATOM   746  C  CA  . HIS A 1 97 ? 20.33585  9.84656  34.86666 1.000 21.90501 ? 97  HIS A CA  1 
ATOM   747  C  C   . HIS A 1 97 ? 20.97863  11.04984 35.54569 1.000 32.87626 ? 97  HIS A C   1 
ATOM   748  O  O   . HIS A 1 97 ? 20.45035  11.60555 36.51276 1.000 31.15269 ? 97  HIS A O   1 
ATOM   749  C  CB  . HIS A 1 97 ? 19.42981  10.33227 33.73731 1.000 32.55694 ? 97  HIS A CB  1 
ATOM   750  C  CG  . HIS A 1 97 ? 18.31000  11.20858 34.20698 1.000 28.47078 ? 97  HIS A CG  1 
ATOM   751  N  ND1 . HIS A 1 97 ? 18.14593  12.50505 33.77016 1.000 38.04562 ? 97  HIS A ND1 1 
ATOM   752  C  CD2 . HIS A 1 97 ? 17.30273  10.97682 35.08182 1.000 31.22345 ? 97  HIS A CD2 1 
ATOM   753  C  CE1 . HIS A 1 97 ? 17.08546  13.03392 34.35400 1.000 37.54072 ? 97  HIS A CE1 1 
ATOM   754  N  NE2 . HIS A 1 97 ? 16.55475  12.12682 35.15382 1.000 31.96248 ? 97  HIS A NE2 1 
ATOM   755  N  N   . HIS A 1 98 ? 22.12949  11.45548 35.01939 1.000 30.65805 ? 98  HIS A N   1 
ATOM   756  C  CA  . HIS A 1 98 ? 22.77267  12.67441 35.48069 1.000 35.08545 ? 98  HIS A CA  1 
ATOM   757  C  C   . HIS A 1 98 ? 21.97231  13.89559 35.04555 1.000 32.98518 ? 98  HIS A C   1 
ATOM   758  O  O   . HIS A 1 98 ? 21.31001  13.89441 34.00479 1.000 35.36419 ? 98  HIS A O   1 
ATOM   759  C  CB  . HIS A 1 98 ? 24.19878  12.76841 34.93481 1.000 32.47402 ? 98  HIS A CB  1 
ATOM   760  C  CG  . HIS A 1 98 ? 25.20765  12.01333 35.74231 1.000 35.93873 ? 98  HIS A CG  1 
ATOM   761  N  ND1 . HIS A 1 98 ? 26.38398  12.58222 36.18178 1.000 43.06969 ? 98  HIS A ND1 1 
ATOM   762  C  CD2 . HIS A 1 98 ? 25.21754  10.73576 36.19018 1.000 38.25897 ? 98  HIS A CD2 1 
ATOM   763  C  CE1 . HIS A 1 98 ? 27.07541  11.68746 36.86483 1.000 42.98319 ? 98  HIS A CE1 1 
ATOM   764  N  NE2 . HIS A 1 98 ? 26.38964  10.55880 36.88541 1.000 40.86532 ? 98  HIS A NE2 1 
ATOM   765  N  N   . HIS A 1 99 ? 22.03218  14.94350 35.86166 1.000 34.96154 ? 99  HIS A N   1 
ATOM   766  C  CA  . HIS A 1 99 ? 21.45717  16.23180 35.48601 1.000 37.31239 ? 99  HIS A CA  1 
ATOM   767  C  C   . HIS A 1 99 ? 22.56055  17.17955 35.04194 1.000 38.24837 ? 99  HIS A C   1 
ATOM   768  O  O   . HIS A 1 99 ? 23.55045  17.35805 35.75181 1.000 38.05891 ? 99  HIS A O   1 
ATOM   769  C  CB  . HIS A 1 99 ? 20.67319  16.84694 36.64607 1.000 37.45086 ? 99  HIS A CB  1 
ATOM   770  C  CG  . HIS A 1 99 ? 19.58490  15.96679 37.16957 1.000 39.98447 ? 99  HIS A CG  1 
ATOM   771  N  ND1 . HIS A 1 99 ? 19.82290  14.68978 37.62969 1.000 40.66699 ? 99  HIS A ND1 1 
ATOM   772  C  CD2 . HIS A 1 99 ? 18.25625  16.17932 37.31633 1.000 42.66393 ? 99  HIS A CD2 1 
ATOM   773  C  CE1 . HIS A 1 99 ? 18.68679  14.15082 38.02735 1.000 38.61197 ? 99  HIS A CE1 1 
ATOM   774  N  NE2 . HIS A 1 99 ? 17.72049  15.03441 37.85227 1.000 47.70260 ? 99  HIS A NE2 1 
ATOM   775  N  N   . ARG B 1 5  ? 9.56057   21.38651 20.21598 1.000 60.93000 ? 5   ARG B N   1 
ATOM   776  C  CA  . ARG B 1 5  ? 10.26804  21.08645 21.45572 1.000 46.22273 ? 5   ARG B CA  1 
ATOM   777  C  C   . ARG B 1 5  ? 11.71194  20.76887 21.07345 1.000 40.20193 ? 5   ARG B C   1 
ATOM   778  O  O   . ARG B 1 5  ? 12.21251  21.29711 20.08369 1.000 40.54245 ? 5   ARG B O   1 
ATOM   779  C  CB  . ARG B 1 5  ? 9.62301   19.91422 22.21288 1.000 33.86300 ? 5   ARG B CB  1 
ATOM   780  C  CG  . ARG B 1 5  ? 8.22559   20.14976 22.85991 1.000 41.44350 ? 5   ARG B CG  1 
ATOM   781  C  CD  . ARG B 1 5  ? 7.24479   20.91735 21.97226 1.000 39.45939 ? 5   ARG B CD  1 
ATOM   782  N  NE  . ARG B 1 5  ? 6.02167   21.34348 22.64434 1.000 42.94782 ? 5   ARG B NE  1 
ATOM   783  C  CZ  . ARG B 1 5  ? 5.05500   20.52684 23.04220 1.000 37.55204 ? 5   ARG B CZ  1 
ATOM   784  N  NH1 . ARG B 1 5  ? 5.15237   19.21510 22.89796 1.000 43.83417 ? 5   ARG B NH1 1 
ATOM   785  N  NH2 . ARG B 1 5  ? 3.95710   21.03986 23.58929 1.000 41.46898 ? 5   ARG B NH2 1 
ATOM   786  N  N   . ALA B 1 6  ? 12.38940  19.91737 21.84349 1.000 46.58000 ? 6   ALA B N   1 
ATOM   787  C  CA  . ALA B 1 6  ? 13.67253  19.39112 21.39232 1.000 36.99447 ? 6   ALA B CA  1 
ATOM   788  C  C   . ALA B 1 6  ? 13.54865  18.03198 20.72395 1.000 25.57492 ? 6   ALA B C   1 
ATOM   789  O  O   . ALA B 1 6  ? 14.39178  17.69153 19.88701 1.000 28.02887 ? 6   ALA B O   1 
ATOM   790  C  CB  . ALA B 1 6  ? 14.67325  19.29471 22.54940 1.000 31.73520 ? 6   ALA B CB  1 
ATOM   791  N  N   . LEU B 1 7  ? 12.53100  17.24225 21.06648 1.000 28.13435 ? 7   LEU B N   1 
ATOM   792  C  CA  . LEU B 1 7  ? 12.22839  16.04359 20.28378 1.000 24.51367 ? 7   LEU B CA  1 
ATOM   793  C  C   . LEU B 1 7  ? 11.49662  16.47628 19.02659 1.000 20.47937 ? 7   LEU B C   1 
ATOM   794  O  O   . LEU B 1 7  ? 10.28744  16.72627 19.04150 1.000 24.60362 ? 7   LEU B O   1 
ATOM   795  C  CB  . LEU B 1 7  ? 11.41016  15.02861 21.06760 1.000 26.57509 ? 7   LEU B CB  1 
ATOM   796  C  CG  . LEU B 1 7  ? 11.39500  13.68328 20.32986 1.000 25.82635 ? 7   LEU B CG  1 
ATOM   797  C  CD1 . LEU B 1 7  ? 12.80775  13.13728 20.13963 1.000 20.61583 ? 7   LEU B CD1 1 
ATOM   798  C  CD2 . LEU B 1 7  ? 10.52248  12.66245 21.04479 1.000 29.71776 ? 7   LEU B CD2 1 
ATOM   799  N  N   . THR B 1 8  ? 12.24768  16.57356 17.94079 1.000 16.90373 ? 8   THR B N   1 
ATOM   800  C  CA  . THR B 1 8  ? 11.74109  16.91824 16.62811 1.000 16.02602 ? 8   THR B CA  1 
ATOM   801  C  C   . THR B 1 8  ? 12.01749  15.75441 15.69329 1.000 17.08205 ? 8   THR B C   1 
ATOM   802  O  O   . THR B 1 8  ? 12.85290  14.89246 15.97823 1.000 16.50685 ? 8   THR B O   1 
ATOM   803  C  CB  . THR B 1 8  ? 12.41302  18.17860 16.08668 1.000 20.52093 ? 8   THR B CB  1 
ATOM   804  O  OG1 . THR B 1 8  ? 13.81527  17.92575 15.92581 1.000 18.61489 ? 8   THR B OG1 1 
ATOM   805  C  CG2 . THR B 1 8  ? 12.22598  19.32910 17.05718 1.000 18.91118 ? 8   THR B CG2 1 
ATOM   806  N  N   . LEU B 1 9  ? 11.30832  15.73194 14.56729 1.000 16.28220 ? 9   LEU B N   1 
ATOM   807  C  CA  . LEU B 1 9  ? 11.63204  14.74278 13.54832 1.000 14.74228 ? 9   LEU B CA  1 
ATOM   808  C  C   . LEU B 1 9  ? 13.07056  14.90699 13.08014 1.000 17.86762 ? 9   LEU B C   1 
ATOM   809  O  O   . LEU B 1 9  ? 13.78080  13.91668 12.86766 1.000 15.52074 ? 9   LEU B O   1 
ATOM   810  C  CB  . LEU B 1 9  ? 10.65662  14.85765 12.38136 1.000 15.61883 ? 9   LEU B CB  1 
ATOM   811  C  CG  . LEU B 1 9  ? 9.22232   14.52213 12.78882 1.000 17.71504 ? 9   LEU B CG  1 
ATOM   812  C  CD1 . LEU B 1 9  ? 8.27011   14.78342 11.63820 1.000 17.95017 ? 9   LEU B CD1 1 
ATOM   813  C  CD2 . LEU B 1 9  ? 9.13807   13.07020 13.25090 1.000 14.17795 ? 9   LEU B CD2 1 
ATOM   814  N  N   . GLU B 1 10 ? 13.53130  16.15571 12.95182 1.000 17.46103 ? 10  GLU B N   1 
ATOM   815  C  CA  . GLU B 1 10 ? 14.91621  16.39596 12.55079 1.000 17.94526 ? 10  GLU B CA  1 
ATOM   816  C  C   . GLU B 1 10 ? 15.90937  15.80634 13.54303 1.000 13.17290 ? 10  GLU B C   1 
ATOM   817  O  O   . GLU B 1 10 ? 16.92794  15.24086 13.13843 1.000 17.81859 ? 10  GLU B O   1 
ATOM   818  C  CB  . GLU B 1 10 ? 15.17188  17.89175 12.37219 1.000 25.34269 ? 10  GLU B CB  1 
ATOM   819  C  CG  . GLU B 1 10 ? 16.40687  18.17460 11.53962 1.000 28.76050 ? 10  GLU B CG  1 
ATOM   820  C  CD  . GLU B 1 10 ? 16.29861  17.64588 10.13169 1.000 34.44351 ? 10  GLU B CD  1 
ATOM   821  O  OE1 . GLU B 1 10 ? 15.17448  17.58702 9.58635  1.000 50.96000 ? 10  GLU B OE1 1 
ATOM   822  O  OE2 . GLU B 1 10 ? 17.34541  17.27661 9.56945  1.000 38.52206 ? 10  GLU B OE2 1 
ATOM   823  N  N   . ALA B 1 11 ? 15.64385  15.94000 14.84265 1.000 13.61688 ? 11  ALA B N   1 
ATOM   824  C  CA  . ALA B 1 11 ? 16.53671  15.33962 15.82900 1.000 11.68023 ? 11  ALA B CA  1 
ATOM   825  C  C   . ALA B 1 11 ? 16.61551  13.83009 15.65061 1.000 13.98206 ? 11  ALA B C   1 
ATOM   826  O  O   . ALA B 1 11 ? 17.70291  13.24305 15.71879 1.000 14.56707 ? 11  ALA B O   1 
ATOM   827  C  CB  . ALA B 1 11 ? 16.07567  15.68935 17.24308 1.000 14.36511 ? 11  ALA B CB  1 
ATOM   828  N  N   . LEU B 1 12 ? 15.47062  13.18371 15.41523 1.000 14.55743 ? 12  LEU B N   1 
ATOM   829  C  CA  . LEU B 1 12 ? 15.46787  11.74283 15.17935 1.000 13.32903 ? 12  LEU B CA  1 
ATOM   830  C  C   . LEU B 1 12 ? 16.22403  11.39494 13.90496 1.000 17.05471 ? 12  LEU B C   1 
ATOM   831  O  O   . LEU B 1 12 ? 16.90424  10.36425 13.83367 1.000 12.52980 ? 12  LEU B O   1 
ATOM   832  C  CB  . LEU B 1 12 ? 14.02856  11.23456 15.10942 1.000 13.97748 ? 12  LEU B CB  1 
ATOM   833  C  CG  . LEU B 1 12 ? 13.24817  11.39341 16.41311 1.000 14.28138 ? 12  LEU B CG  1 
ATOM   834  C  CD1 . LEU B 1 12 ? 11.80470  10.95055 16.21818 1.000 17.81868 ? 12  LEU B CD1 1 
ATOM   835  C  CD2 . LEU B 1 12 ? 13.91165  10.59985 17.53148 1.000 16.18074 ? 12  LEU B CD2 1 
ATOM   836  N  N   . ARG B 1 13 ? 16.11895  12.24947 12.88754 1.000 13.60106 ? 13  ARG B N   1 
ATOM   837  C  CA  . ARG B 1 13 ? 16.85478  12.03556 11.64846 1.000 12.93628 ? 13  ARG B CA  1 
ATOM   838  C  C   . ARG B 1 13 ? 18.35426  12.18001 11.86775 1.000 14.34205 ? 13  ARG B C   1 
ATOM   839  O  O   . ARG B 1 13 ? 19.14882  11.42909 11.29016 1.000 13.43056 ? 13  ARG B O   1 
ATOM   840  C  CB  . ARG B 1 13 ? 16.36028  13.02403 10.59366 1.000 15.98712 ? 13  ARG B CB  1 
ATOM   841  C  CG  . ARG B 1 13 ? 15.24084  12.47181 9.74265  1.000 24.45460 ? 13  ARG B CG  1 
ATOM   842  C  CD  . ARG B 1 13 ? 14.77951  13.44780 8.66140  1.000 25.66861 ? 13  ARG B CD  1 
ATOM   843  N  NE  . ARG B 1 13 ? 13.35934  13.25306 8.39052  1.000 29.05049 ? 13  ARG B NE  1 
ATOM   844  C  CZ  . ARG B 1 13 ? 12.39184  14.09374 8.72850  1.000 25.10140 ? 13  ARG B CZ  1 
ATOM   845  N  NH1 . ARG B 1 13 ? 12.65422  15.27237 9.26820  1.000 26.14528 ? 13  ARG B NH1 1 
ATOM   846  N  NH2 . ARG B 1 13 ? 11.12734  13.74740 8.50400  1.000 29.17882 ? 13  ARG B NH2 1 
ATOM   847  N  N   . VAL B 1 14 ? 18.76006  13.15097 12.68858 1.000 14.52458 ? 14  VAL B N   1 
ATOM   848  C  CA  . VAL B 1 14 ? 20.17150  13.28802 13.03575 1.000 12.32897 ? 14  VAL B CA  1 
ATOM   849  C  C   . VAL B 1 14 ? 20.66176  12.03337 13.74196 1.000 14.11228 ? 14  VAL B C   1 
ATOM   850  O  O   . VAL B 1 14 ? 21.73231  11.49666 13.43309 1.000 14.01992 ? 14  VAL B O   1 
ATOM   851  C  CB  . VAL B 1 14 ? 20.39003  14.53673 13.90694 1.000 15.66779 ? 14  VAL B CB  1 
ATOM   852  C  CG1 . VAL B 1 14 ? 21.82606  14.58742 14.39537 1.000 15.08999 ? 14  VAL B CG1 1 
ATOM   853  C  CG2 . VAL B 1 14 ? 20.03802  15.79320 13.12395 1.000 16.49022 ? 14  VAL B CG2 1 
ATOM   854  N  N   . MET B 1 15 ? 19.87934  11.55182 14.70904 1.000 12.84033 ? 15  MET B N   1 
ATOM   855  C  CA  . MET B 1 15 ? 20.24515  10.34683 15.44214 1.000 13.77399 ? 15  MET B CA  1 
ATOM   856  C  C   . MET B 1 15 ? 20.36581  9.15917  14.49277 1.000 13.08893 ? 15  MET B C   1 
ATOM   857  O  O   . MET B 1 15 ? 21.32837  8.38509  14.56141 1.000 12.73166 ? 15  MET B O   1 
ATOM   858  C  CB  . MET B 1 15 ? 19.18423  10.08988 16.50822 1.000 13.96706 ? 15  MET B CB  1 
ATOM   859  C  CG  . MET B 1 15 ? 19.40220  10.93514 17.74332 1.000 16.19499 ? 15  MET B CG  1 
ATOM   860  S  SD  . MET B 1 15 ? 18.22856  10.57240 19.04252 1.000 15.84809 ? 15  MET B SD  1 
ATOM   861  C  CE  . MET B 1 15 ? 19.04601  9.16687  19.78309 1.000 19.17032 ? 15  MET B CE  1 
ATOM   862  N  N   . ASP B 1 16 ? 19.40596  9.02262  13.57688 1.000 12.03535 ? 16  ASP B N   1 
ATOM   863  C  CA  . ASP B 1 16 ? 19.44235  7.93764  12.60116 1.000 15.67895 ? 16  ASP B CA  1 
ATOM   864  C  C   . ASP B 1 16 ? 20.68723  8.02259  11.72767 1.000 13.39350 ? 16  ASP B C   1 
ATOM   865  O  O   . ASP B 1 16 ? 21.36622  7.01498  11.49872 1.000 14.19755 ? 16  ASP B O   1 
ATOM   866  C  CB  . ASP B 1 16 ? 18.16890  7.98015  11.75688 1.000 11.11648 ? 16  ASP B CB  1 
ATOM   867  C  CG  . ASP B 1 16 ? 18.19883  7.00942  10.59580 1.000 17.83064 ? 16  ASP B CG  1 
ATOM   868  O  OD1 . ASP B 1 16 ? 18.30721  5.79300  10.83671 1.000 16.30047 ? 16  ASP B OD1 1 
ATOM   869  O  OD2 . ASP B 1 16 ? 18.08347  7.46225  9.44240  1.000 19.67242 ? 16  ASP B OD2 1 
ATOM   870  N  N   . ALA B 1 17 ? 21.01946  9.22424  11.25033 1.000 15.87454 ? 17  ALA B N   1 
ATOM   871  C  CA  . ALA B 1 17 ? 22.16896  9.36708  10.36094 1.000 14.31422 ? 17  ALA B CA  1 
ATOM   872  C  C   . ALA B 1 17 ? 23.48063  9.10929  11.09455 1.000 13.02274 ? 17  ALA B C   1 
ATOM   873  O  O   . ALA B 1 17 ? 24.41205  8.53780  10.52071 1.000 17.24904 ? 17  ALA B O   1 
ATOM   874  C  CB  . ALA B 1 17 ? 22.17127  10.75727 9.72480  1.000 14.33753 ? 17  ALA B CB  1 
ATOM   875  N  N   . ILE B 1 18 ? 23.58089  9.52805  12.35960 1.000 12.65816 ? 18  ILE B N   1 
ATOM   876  C  CA  . ILE B 1 18 ? 24.79935  9.26644  13.12388 1.000 12.56727 ? 18  ILE B CA  1 
ATOM   877  C  C   . ILE B 1 18 ? 24.99224  7.76794  13.31834 1.000 16.61586 ? 18  ILE B C   1 
ATOM   878  O  O   . ILE B 1 18 ? 26.11025  7.24617  13.19960 1.000 15.60076 ? 18  ILE B O   1 
ATOM   879  C  CB  . ILE B 1 18 ? 24.75796  10.01120 14.47116 1.000 16.34452 ? 18  ILE B CB  1 
ATOM   880  C  CG1 . ILE B 1 18 ? 24.96135  11.51293 14.25829 1.000 15.99533 ? 18  ILE B CG1 1 
ATOM   881  C  CG2 . ILE B 1 18 ? 25.81116  9.47189  15.42278 1.000 14.98874 ? 18  ILE B CG2 1 
ATOM   882  C  CD1 . ILE B 1 18 ? 24.56293  12.33970 15.45738 1.000 14.72691 ? 18  ILE B CD1 1 
ATOM   883  N  N   . ASP B 1 19 ? 23.91037  7.05089  13.62261 1.000 13.51942 ? 19  ASP B N   1 
ATOM   884  C  CA  . ASP B 1 19 ? 24.00663  5.59934  13.76778 1.000 14.47655 ? 19  ASP B CA  1 
ATOM   885  C  C   . ASP B 1 19 ? 24.42904  4.94339  12.45786 1.000 14.98660 ? 19  ASP B C   1 
ATOM   886  O  O   . ASP B 1 19 ? 25.32000  4.08536  12.43525 1.000 15.85807 ? 19  ASP B O   1 
ATOM   887  C  CB  . ASP B 1 19 ? 22.66904  5.02618  14.24375 1.000 13.47457 ? 19  ASP B CB  1 
ATOM   888  C  CG  . ASP B 1 19 ? 22.71842  3.52080  14.43443 1.000 22.15049 ? 19  ASP B CG  1 
ATOM   889  O  OD1 . ASP B 1 19 ? 23.57266  3.04878  15.21272 1.000 22.94424 ? 19  ASP B OD1 1 
ATOM   890  O  OD2 . ASP B 1 19 ? 21.91196  2.80822  13.79731 1.000 15.53542 ? 19  ASP B OD2 1 
ATOM   891  N  N   . ARG B 1 20 ? 23.79588  5.33853  11.35229 1.000 15.51654 ? 20  ARG B N   1 
ATOM   892  C  CA  . ARG B 1 20 ? 24.03176  4.67401  10.07400 1.000 17.56739 ? 20  ARG B CA  1 
ATOM   893  C  C   . ARG B 1 20 ? 25.40667  5.01077  9.51432  1.000 18.76922 ? 20  ARG B C   1 
ATOM   894  O  O   . ARG B 1 20 ? 26.12259  4.12946  9.02915  1.000 19.85343 ? 20  ARG B O   1 
ATOM   895  C  CB  . ARG B 1 20 ? 22.95145  5.06809  9.06863  1.000 17.27292 ? 20  ARG B CB  1 
ATOM   896  C  CG  . ARG B 1 20 ? 21.61548  4.38578  9.27145  1.000 18.64539 ? 20  ARG B CG  1 
ATOM   897  C  CD  . ARG B 1 20 ? 20.64194  4.71762  8.12402  1.000 17.30686 ? 20  ARG B CD  1 
ATOM   898  N  NE  . ARG B 1 20 ? 20.17731  6.10007  8.15475  1.000 19.68532 ? 20  ARG B NE  1 
ATOM   899  C  CZ  . ARG B 1 20 ? 20.74023  7.10502  7.49690  1.000 18.74752 ? 20  ARG B CZ  1 
ATOM   900  N  NH1 . ARG B 1 20 ? 21.77479  6.91485  6.69206  1.000 19.28813 ? 20  ARG B NH1 1 
ATOM   901  N  NH2 . ARG B 1 20 ? 20.24874  8.33151  7.64569  1.000 19.47778 ? 20  ARG B NH2 1 
ATOM   902  N  N   . ARG B 1 21 ? 25.79040  6.28046  9.55811  1.000 19.00003 ? 21  ARG B N   1 
ATOM   903  C  CA  . ARG B 1 21 ? 27.05351  6.68298  8.95657  1.000 21.37135 ? 21  ARG B CA  1 
ATOM   904  C  C   . ARG B 1 21 ? 28.22578  6.58925  9.92524  1.000 21.34461 ? 21  ARG B C   1 
ATOM   905  O  O   . ARG B 1 21 ? 29.37419  6.48171  9.47894  1.000 25.82266 ? 21  ARG B O   1 
ATOM   906  C  CB  . ARG B 1 21 ? 26.93062  8.10065  8.39150  1.000 19.76318 ? 21  ARG B CB  1 
ATOM   907  C  CG  . ARG B 1 21 ? 25.73359  8.27248  7.47090  1.000 17.55789 ? 21  ARG B CG  1 
ATOM   908  C  CD  . ARG B 1 21 ? 25.92670  7.52203  6.14905  1.000 26.20610 ? 21  ARG B CD  1 
ATOM   909  N  NE  . ARG B 1 21 ? 24.92620  7.89516  5.15525  1.000 27.45579 ? 21  ARG B NE  1 
ATOM   910  C  CZ  . ARG B 1 21 ? 24.94945  7.51509  3.88441  1.000 42.37000 ? 21  ARG B CZ  1 
ATOM   911  N  NH1 . ARG B 1 21 ? 25.92398  6.75866  3.40703  1.000 45.51249 ? 21  ARG B NH1 1 
ATOM   912  N  NH2 . ARG B 1 21 ? 23.96583  7.89819  3.07366  1.000 32.74700 ? 21  ARG B NH2 1 
ATOM   913  N  N   . GLY B 1 22 ? 27.96737  6.61070  11.23008 1.000 22.10357 ? 22  GLY B N   1 
ATOM   914  C  CA  . GLY B 1 22 ? 28.96753  6.28760  12.22887 1.000 26.02590 ? 22  GLY B CA  1 
ATOM   915  C  C   . GLY B 1 22 ? 29.53045  7.46413  12.99250 1.000 23.84115 ? 22  GLY B C   1 
ATOM   916  O  O   . GLY B 1 22 ? 30.18484  7.24930  14.02068 1.000 32.43026 ? 22  GLY B O   1 
ATOM   917  N  N   . SER B 1 23 ? 29.29688  8.69419  12.54732 1.000 21.33086 ? 23  SER B N   1 
ATOM   918  C  CA  . SER B 1 23 ? 29.92620  9.84162  13.18665 1.000 21.30749 ? 23  SER B CA  1 
ATOM   919  C  C   . SER B 1 23 ? 29.13397  11.09732 12.86113 1.000 26.21390 ? 23  SER B C   1 
ATOM   920  O  O   . SER B 1 23 ? 28.27862  11.10732 11.97373 1.000 24.64547 ? 23  SER B O   1 
ATOM   921  C  CB  . SER B 1 23 ? 31.37934  9.99832  12.73480 1.000 25.85425 ? 23  SER B CB  1 
ATOM   922  O  OG  . SER B 1 23 ? 31.43654  10.38829 11.37329 1.000 25.38492 ? 23  SER B OG  1 
ATOM   923  N  N   . PHE B 1 24 ? 29.43800  12.16544 13.60119 1.000 21.74428 ? 24  PHE B N   1 
ATOM   924  C  CA  . PHE B 1 24 ? 28.86445  13.46808 13.28926 1.000 22.37192 ? 24  PHE B CA  1 
ATOM   925  C  C   . PHE B 1 24 ? 29.23651  13.90107 11.87805 1.000 24.21356 ? 24  PHE B C   1 
ATOM   926  O  O   . PHE B 1 24 ? 28.37603  14.32138 11.09773 1.000 24.71698 ? 24  PHE B O   1 
ATOM   927  C  CB  . PHE B 1 24 ? 29.34100  14.50737 14.29964 1.000 25.83166 ? 24  PHE B CB  1 
ATOM   928  C  CG  . PHE B 1 24 ? 28.47760  14.61534 15.52041 1.000 25.44281 ? 24  PHE B CG  1 
ATOM   929  C  CD1 . PHE B 1 24 ? 27.21262  15.16714 15.44066 1.000 21.90057 ? 24  PHE B CD1 1 
ATOM   930  C  CD2 . PHE B 1 24 ? 28.93986  14.18248 16.75126 1.000 32.46880 ? 24  PHE B CD2 1 
ATOM   931  C  CE1 . PHE B 1 24 ? 26.41585  15.27487 16.56305 1.000 23.44473 ? 24  PHE B CE1 1 
ATOM   932  C  CE2 . PHE B 1 24 ? 28.15003  14.28972 17.88106 1.000 32.66082 ? 24  PHE B CE2 1 
ATOM   933  C  CZ  . PHE B 1 24 ? 26.88583  14.83654 17.78662 1.000 27.52869 ? 24  PHE B CZ  1 
ATOM   934  N  N   . ALA B 1 25 ? 30.52304  13.80138 11.53471 1.000 26.86300 ? 25  ALA B N   1 
ATOM   935  C  CA  . ALA B 1 25 ? 31.00199  14.31610 10.25547 1.000 23.29539 ? 25  ALA B CA  1 
ATOM   936  C  C   . ALA B 1 25 ? 30.36496  13.57819 9.08379  1.000 23.64439 ? 25  ALA B C   1 
ATOM   937  O  O   . ALA B 1 25 ? 29.93476  14.19765 8.10355  1.000 25.05733 ? 25  ALA B O   1 
ATOM   938  C  CB  . ALA B 1 25 ? 32.52515  14.21614 10.19485 1.000 29.04382 ? 25  ALA B CB  1 
ATOM   939  N  N   . ALA B 1 26 ? 30.29581  12.24888 9.16643  1.000 24.70672 ? 26  ALA B N   1 
ATOM   940  C  CA  . ALA B 1 26 ? 29.69188  11.47982 8.08356  1.000 25.89837 ? 26  ALA B CA  1 
ATOM   941  C  C   . ALA B 1 26 ? 28.18897  11.72553 8.00073  1.000 21.19481 ? 26  ALA B C   1 
ATOM   942  O  O   . ALA B 1 26 ? 27.62946  11.82594 6.90259  1.000 21.92635 ? 26  ALA B O   1 
ATOM   943  C  CB  . ALA B 1 26 ? 29.98980  9.99233  8.26902  1.000 29.04272 ? 26  ALA B CB  1 
ATOM   944  N  N   . ALA B 1 27 ? 27.51817  11.82907 9.14983  1.000 22.20120 ? 27  ALA B N   1 
ATOM   945  C  CA  . ALA B 1 27 ? 26.08753  12.11683 9.14277  1.000 18.61262 ? 27  ALA B CA  1 
ATOM   946  C  C   . ALA B 1 27 ? 25.80743  13.50799 8.58746  1.000 19.26755 ? 27  ALA B C   1 
ATOM   947  O  O   . ALA B 1 27 ? 24.84471  13.70129 7.83529  1.000 16.60468 ? 27  ALA B O   1 
ATOM   948  C  CB  . ALA B 1 27 ? 25.51678  11.97648 10.55488 1.000 16.02837 ? 27  ALA B CB  1 
ATOM   949  N  N   . ALA B 1 28 ? 26.63144  14.49287 8.95512  1.000 16.22626 ? 28  ALA B N   1 
ATOM   950  C  CA  . ALA B 1 28 ? 26.44883  15.83983 8.42506  1.000 20.22131 ? 28  ALA B CA  1 
ATOM   951  C  C   . ALA B 1 28 ? 26.62003  15.85684 6.91345  1.000 24.66678 ? 28  ALA B C   1 
ATOM   952  O  O   . ALA B 1 28 ? 25.95178  16.62563 6.21137  1.000 23.41653 ? 28  ALA B O   1 
ATOM   953  C  CB  . ALA B 1 28 ? 27.42980  16.80496 9.08828  1.000 20.71873 ? 28  ALA B CB  1 
ATOM   954  N  N   . ASP B 1 29 ? 27.51883  15.01797 6.39812  1.000 23.27008 ? 29  ASP B N   1 
ATOM   955  C  CA  . ASP B 1 29 ? 27.65498  14.85913 4.95433  1.000 23.04164 ? 29  ASP B CA  1 
ATOM   956  C  C   . ASP B 1 29 ? 26.33918  14.42199 4.32634  1.000 29.65520 ? 29  ASP B C   1 
ATOM   957  O  O   . ASP B 1 29 ? 25.88995  14.99655 3.32868  1.000 27.51920 ? 29  ASP B O   1 
ATOM   958  C  CB  . ASP B 1 29 ? 28.75494  13.84459 4.65720  1.000 27.51446 ? 29  ASP B CB  1 
ATOM   959  C  CG  . ASP B 1 29 ? 29.27187  13.94225 3.24639  1.000 43.74950 ? 29  ASP B CG  1 
ATOM   960  O  OD1 . ASP B 1 29 ? 29.84239  12.94311 2.76486  1.000 45.48534 ? 29  ASP B OD1 1 
ATOM   961  O  OD2 . ASP B 1 29 ? 29.10082  15.01171 2.62170  1.000 47.07575 ? 29  ASP B OD2 1 
ATOM   962  N  N   . GLU B 1 30 ? 25.70656  13.40150 4.90723  1.000 25.45200 ? 30  GLU B N   1 
ATOM   963  C  CA  . GLU B 1 30 ? 24.42795  12.91577 4.39957  1.000 27.96557 ? 30  GLU B CA  1 
ATOM   964  C  C   . GLU B 1 30 ? 23.37266  14.01394 4.41381  1.000 28.26817 ? 30  GLU B C   1 
ATOM   965  O  O   . GLU B 1 30 ? 22.66603  14.22958 3.42231  1.000 25.35793 ? 30  GLU B O   1 
ATOM   966  C  CB  . GLU B 1 30 ? 23.95909  11.73343 5.24347  1.000 24.38350 ? 30  GLU B CB  1 
ATOM   967  C  CG  . GLU B 1 30 ? 22.45418  11.56726 5.23581  1.000 35.98000 ? 30  GLU B CG  1 
ATOM   968  C  CD  . GLU B 1 30 ? 22.01173  10.14842 5.47237  1.000 22.08533 ? 30  GLU B CD  1 
ATOM   969  O  OE1 . GLU B 1 30 ? 22.84247  9.22643  5.35002  1.000 25.60212 ? 30  GLU B OE1 1 
ATOM   970  O  OE2 . GLU B 1 30 ? 20.82069  9.96771  5.78321  1.000 25.06770 ? 30  GLU B OE2 1 
ATOM   971  N  N   . LEU B 1 31 ? 23.24038  14.70885 5.54424  1.000 25.00799 ? 31  LEU B N   1 
ATOM   972  C  CA  . LEU B 1 31 ? 22.17403  15.68138 5.73042  1.000 19.33123 ? 31  LEU B CA  1 
ATOM   973  C  C   . LEU B 1 31 ? 22.46243  17.01791 5.06285  1.000 23.30791 ? 31  LEU B C   1 
ATOM   974  O  O   . LEU B 1 31 ? 21.58013  17.88122 5.04370  1.000 28.79784 ? 31  LEU B O   1 
ATOM   975  C  CB  . LEU B 1 31 ? 21.91978  15.88512 7.22626  1.000 21.68256 ? 31  LEU B CB  1 
ATOM   976  C  CG  . LEU B 1 31 ? 21.37161  14.65061 7.95230  1.000 22.50470 ? 31  LEU B CG  1 
ATOM   977  C  CD1 . LEU B 1 31 ? 21.07700  14.96407 9.42273  1.000 27.04178 ? 31  LEU B CD1 1 
ATOM   978  C  CD2 . LEU B 1 31 ? 20.12487  14.12131 7.26195  1.000 25.13841 ? 31  LEU B CD2 1 
ATOM   979  N  N   . GLY B 1 32 ? 23.66119  17.20720 4.51807  1.000 24.63077 ? 32  GLY B N   1 
ATOM   980  C  CA  . GLY B 1 32 ? 23.99345  18.45446 3.85634  1.000 29.81660 ? 32  GLY B CA  1 
ATOM   981  C  C   . GLY B 1 32 ? 24.10654  19.64483 4.78043  1.000 28.72970 ? 32  GLY B C   1 
ATOM   982  O  O   . GLY B 1 32 ? 23.83890  20.77299 4.36032  1.000 26.79122 ? 32  GLY B O   1 
ATOM   983  N  N   . ARG B 1 33 ? 24.48988  19.42425 6.03389  1.000 25.66407 ? 33  ARG B N   1 
ATOM   984  C  CA  . ARG B 1 33 ? 24.68143  20.49479 6.99674  1.000 23.38352 ? 33  ARG B CA  1 
ATOM   985  C  C   . ARG B 1 33 ? 26.09825  20.42433 7.54683  1.000 20.91146 ? 33  ARG B C   1 
ATOM   986  O  O   . ARG B 1 33 ? 26.79300  19.41585 7.39587  1.000 23.39066 ? 33  ARG B O   1 
ATOM   987  C  CB  . ARG B 1 33 ? 23.66674  20.40499 8.14531  1.000 24.83036 ? 33  ARG B CB  1 
ATOM   988  C  CG  . ARG B 1 33 ? 22.22900  20.20850 7.69212  1.000 34.48979 ? 33  ARG B CG  1 
ATOM   989  C  CD  . ARG B 1 33 ? 21.36152  19.69070 8.82967  1.000 38.40162 ? 33  ARG B CD  1 
ATOM   990  N  NE  . ARG B 1 33 ? 19.99988  20.20753 8.75950  1.000 46.46594 ? 33  ARG B NE  1 
ATOM   991  C  CZ  . ARG B 1 33 ? 19.36109  20.78611 9.76704  1.000 54.88663 ? 33  ARG B CZ  1 
ATOM   992  N  NH1 . ARG B 1 33 ? 19.93926  20.96007 10.94443 1.000 44.24861 ? 33  ARG B NH1 1 
ATOM   993  N  NH2 . ARG B 1 33 ? 18.11040  21.20179 9.58801  1.000 60.70400 ? 33  ARG B NH2 1 
ATOM   994  N  N   . VAL B 1 34 ? 26.53035  21.50957 8.18095  1.000 21.77066 ? 34  VAL B N   1 
ATOM   995  C  CA  . VAL B 1 34 ? 27.81804  21.49741 8.87051  1.000 21.34327 ? 34  VAL B CA  1 
ATOM   996  C  C   . VAL B 1 34 ? 27.66368  20.65846 10.13159 1.000 18.42448 ? 34  VAL B C   1 
ATOM   997  O  O   . VAL B 1 34 ? 26.56350  20.59885 10.70100 1.000 22.34308 ? 34  VAL B O   1 
ATOM   998  C  CB  . VAL B 1 34 ? 28.30935  22.91493 9.19949  1.000 19.72936 ? 34  VAL B CB  1 
ATOM   999  C  CG1 . VAL B 1 34 ? 28.62903  23.66969 7.91828  1.000 21.68217 ? 34  VAL B CG1 1 
ATOM   1000 C  CG2 . VAL B 1 34 ? 27.27590  23.65305 10.04335 1.000 22.15604 ? 34  VAL B CG2 1 
ATOM   1001 N  N   . PRO B 1 35 ? 28.72329  19.98591 10.59076 1.000 17.60039 ? 35  PRO B N   1 
ATOM   1002 C  CA  . PRO B 1 35 ? 28.57860  19.11767 11.77300 1.000 17.10328 ? 35  PRO B CA  1 
ATOM   1003 C  C   . PRO B 1 35 ? 28.03017  19.83053 12.99619 1.000 15.39586 ? 35  PRO B C   1 
ATOM   1004 O  O   . PRO B 1 35 ? 27.26676  19.23136 13.76520 1.000 16.80483 ? 35  PRO B O   1 
ATOM   1005 C  CB  . PRO B 1 35 ? 30.00946  18.61475 12.00166 1.000 16.16204 ? 35  PRO B CB  1 
ATOM   1006 C  CG  . PRO B 1 35 ? 30.62064  18.62245 10.63550 1.000 22.52714 ? 35  PRO B CG  1 
ATOM   1007 C  CD  . PRO B 1 35 ? 30.03208  19.81699 9.93242  1.000 19.39344 ? 35  PRO B CD  1 
ATOM   1008 N  N   . SER B 1 36 ? 28.38630  21.10006 13.20072 1.000 15.56467 ? 36  SER B N   1 
ATOM   1009 C  CA  . SER B 1 36 ? 27.92854  21.79217 14.40188 1.000 17.36240 ? 36  SER B CA  1 
ATOM   1010 C  C   . SER B 1 36 ? 26.41325  21.93323 14.41926 1.000 17.62963 ? 36  SER B C   1 
ATOM   1011 O  O   . SER B 1 36 ? 25.81003  22.00285 15.49477 1.000 19.77610 ? 36  SER B O   1 
ATOM   1012 C  CB  . SER B 1 36 ? 28.59348  23.16788 14.51826 1.000 16.99041 ? 36  SER B CB  1 
ATOM   1013 O  OG  . SER B 1 36 ? 28.08798  24.06997 13.54905 1.000 18.81018 ? 36  SER B OG  1 
ATOM   1014 N  N   . ALA B 1 37 ? 25.77842  21.96771 13.24541 1.000 17.40998 ? 37  ALA B N   1 
ATOM   1015 C  CA  . ALA B 1 37 ? 24.32006  21.98772 13.21125 1.000 23.88478 ? 37  ALA B CA  1 
ATOM   1016 C  C   . ALA B 1 37 ? 23.74703  20.71521 13.82125 1.000 20.87238 ? 37  ALA B C   1 
ATOM   1017 O  O   . ALA B 1 37 ? 22.71421  20.74830 14.50146 1.000 20.29257 ? 37  ALA B O   1 
ATOM   1018 C  CB  . ALA B 1 37 ? 23.83082  22.16510 11.77396 1.000 22.09731 ? 37  ALA B CB  1 
ATOM   1019 N  N   . LEU B 1 38 ? 24.41601  19.58388 13.59993 1.000 16.92726 ? 38  LEU B N   1 
ATOM   1020 C  CA  . LEU B 1 38 ? 23.94042  18.32153 14.15438 1.000 15.52969 ? 38  LEU B CA  1 
ATOM   1021 C  C   . LEU B 1 38 ? 24.18794  18.25129 15.65421 1.000 17.08307 ? 38  LEU B C   1 
ATOM   1022 O  O   . LEU B 1 38 ? 23.32579  17.78825 16.40807 1.000 17.89820 ? 38  LEU B O   1 
ATOM   1023 C  CB  . LEU B 1 38 ? 24.61428  17.14860 13.44026 1.000 17.95667 ? 38  LEU B CB  1 
ATOM   1024 C  CG  . LEU B 1 38 ? 24.00096  16.69657 12.11453 1.000 19.38259 ? 38  LEU B CG  1 
ATOM   1025 C  CD1 . LEU B 1 38 ? 24.18550  17.73990 11.02122 1.000 18.48064 ? 38  LEU B CD1 1 
ATOM   1026 C  CD2 . LEU B 1 38 ? 24.61199  15.36589 11.68955 1.000 18.03946 ? 38  LEU B CD2 1 
ATOM   1027 N  N   . SER B 1 39 ? 25.35926  18.71018 16.10939 1.000 17.87831 ? 39  SER B N   1 
ATOM   1028 C  CA  . SER B 1 39 ? 25.64143  18.70029 17.54117 1.000 17.40661 ? 39  SER B CA  1 
ATOM   1029 C  C   . SER B 1 39 ? 24.75561  19.68039 18.29516 1.000 17.13645 ? 39  SER B C   1 
ATOM   1030 O  O   . SER B 1 39 ? 24.39510  19.42297 19.44771 1.000 19.66141 ? 39  SER B O   1 
ATOM   1031 C  CB  . SER B 1 39 ? 27.11721  19.02004 17.79738 1.000 20.55285 ? 39  SER B CB  1 
ATOM   1032 O  OG  . SER B 1 39 ? 27.95017  17.94895 17.38930 1.000 26.71312 ? 39  SER B OG  1 
ATOM   1033 N  N   . TYR B 1 40 ? 24.40947  20.81171 17.67790 1.000 18.58634 ? 40  TYR B N   1 
ATOM   1034 C  CA  . TYR B 1 40 ? 23.50095  21.74727 18.33086 1.000 22.03128 ? 40  TYR B CA  1 
ATOM   1035 C  C   . TYR B 1 40 ? 22.14837  21.09458 18.57381 1.000 18.44056 ? 40  TYR B C   1 
ATOM   1036 O  O   . TYR B 1 40 ? 21.59707  21.16546 19.67903 1.000 20.54175 ? 40  TYR B O   1 
ATOM   1037 C  CB  . TYR B 1 40 ? 23.36224  23.01243 17.48509 1.000 23.12817 ? 40  TYR B CB  1 
ATOM   1038 C  CG  . TYR B 1 40 ? 22.54767  24.10172 18.13474 1.000 27.46339 ? 40  TYR B CG  1 
ATOM   1039 C  CD1 . TYR B 1 40 ? 23.16519  25.10082 18.87068 1.000 32.35010 ? 40  TYR B CD1 1 
ATOM   1040 C  CD2 . TYR B 1 40 ? 21.16990  24.16021 17.97339 1.000 32.51237 ? 40  TYR B CD2 1 
ATOM   1041 C  CE1 . TYR B 1 40 ? 22.43299  26.10834 19.46249 1.000 40.33528 ? 40  TYR B CE1 1 
ATOM   1042 C  CE2 . TYR B 1 40 ? 20.42703  25.16744 18.56285 1.000 40.52914 ? 40  TYR B CE2 1 
ATOM   1043 C  CZ  . TYR B 1 40 ? 21.06709  26.13886 19.30558 1.000 38.30960 ? 40  TYR B CZ  1 
ATOM   1044 O  OH  . TYR B 1 40 ? 20.33934  27.14814 19.89159 1.000 51.62533 ? 40  TYR B OH  1 
ATOM   1045 N  N   . THR B 1 41 ? 21.61042  20.43290 17.54867 1.000 20.15568 ? 41  THR B N   1 
ATOM   1046 C  CA  . THR B 1 41 ? 20.35384  19.71252 17.70416 1.000 18.68216 ? 41  THR B CA  1 
ATOM   1047 C  C   . THR B 1 41 ? 20.45275  18.68620 18.82240 1.000 18.39292 ? 41  THR B C   1 
ATOM   1048 O  O   . THR B 1 41 ? 19.54342  18.56759 19.65274 1.000 19.84337 ? 41  THR B O   1 
ATOM   1049 C  CB  . THR B 1 41 ? 19.97968  19.03145 16.38695 1.000 17.11395 ? 41  THR B CB  1 
ATOM   1050 O  OG1 . THR B 1 41 ? 19.94839  20.00477 15.33753 1.000 20.34236 ? 41  THR B OG1 1 
ATOM   1051 C  CG2 . THR B 1 41 ? 18.61674  18.37985 16.49225 1.000 16.91361 ? 41  THR B CG2 1 
ATOM   1052 N  N   . MET B 1 42 ? 21.56422  17.95003 18.87182 1.000 17.75312 ? 42  MET B N   1 
ATOM   1053 C  CA  . MET B 1 42 ? 21.70096  16.88941 19.86170 1.000 14.39565 ? 42  MET B CA  1 
ATOM   1054 C  C   . MET B 1 42 ? 21.91774  17.46903 21.25200 1.000 18.82533 ? 42  MET B C   1 
ATOM   1055 O  O   . MET B 1 42 ? 21.44505  16.90640 22.24572 1.000 16.87397 ? 42  MET B O   1 
ATOM   1056 C  CB  . MET B 1 42 ? 22.86202  15.97057 19.49111 1.000 14.03269 ? 42  MET B CB  1 
ATOM   1057 C  CG  . MET B 1 42 ? 22.63877  15.11456 18.24256 1.000 14.49205 ? 42  MET B CG  1 
ATOM   1058 S  SD  . MET B 1 42 ? 21.27850  13.93423 18.31639 1.000 20.28167 ? 42  MET B SD  1 
ATOM   1059 C  CE  . MET B 1 42 ? 19.89013  14.92261 17.77907 1.000 16.93377 ? 42  MET B CE  1 
ATOM   1060 N  N   . GLN B 1 43 ? 22.65167  18.58025 21.34380 1.000 18.01913 ? 43  GLN B N   1 
ATOM   1061 C  CA  . GLN B 1 43 ? 22.82429  19.24014 22.63455 1.000 16.95158 ? 43  GLN B CA  1 
ATOM   1062 C  C   . GLN B 1 43 ? 21.48416  19.66915 23.21750 1.000 18.67902 ? 43  GLN B C   1 
ATOM   1063 O  O   . GLN B 1 43 ? 21.22219  19.46355 24.40833 1.000 19.15691 ? 43  GLN B O   1 
ATOM   1064 C  CB  . GLN B 1 43 ? 23.74741  20.44970 22.48983 1.000 18.50264 ? 43  GLN B CB  1 
ATOM   1065 C  CG  . GLN B 1 43 ? 23.86470  21.27572 23.76545 1.000 20.57617 ? 43  GLN B CG  1 
ATOM   1066 C  CD  . GLN B 1 43 ? 24.75420  22.49215 23.59849 1.000 25.95021 ? 43  GLN B CD  1 
ATOM   1067 O  OE1 . GLN B 1 43 ? 25.48497  22.61043 22.61865 1.000 27.78905 ? 43  GLN B OE1 1 
ATOM   1068 N  NE2 . GLN B 1 43 ? 24.69772  23.40473 24.56403 1.000 26.61389 ? 43  GLN B NE2 1 
ATOM   1069 N  N   . LYS B 1 44 ? 20.62186  20.27097 22.39476 1.000 21.84501 ? 44  LYS B N   1 
ATOM   1070 C  CA  . LYS B 1 44 ? 19.33333  20.73443 22.90166 1.000 21.59381 ? 44  LYS B CA  1 
ATOM   1071 C  C   . LYS B 1 44 ? 18.47255  19.56715 23.36415 1.000 23.66468 ? 44  LYS B C   1 
ATOM   1072 O  O   . LYS B 1 44 ? 17.78239  19.66068 24.38712 1.000 24.48732 ? 44  LYS B O   1 
ATOM   1073 C  CB  . LYS B 1 44 ? 18.60307  21.54729 21.83305 1.000 25.23897 ? 44  LYS B CB  1 
ATOM   1074 C  CG  . LYS B 1 44 ? 19.20887  22.91816 21.55403 1.000 33.42787 ? 44  LYS B CG  1 
ATOM   1075 C  CD  . LYS B 1 44 ? 19.81859  23.55710 22.79845 1.000 38.78019 ? 44  LYS B CD  1 
ATOM   1076 C  CE  . LYS B 1 44 ? 18.75779  24.20541 23.67961 1.000 50.73529 ? 44  LYS B CE  1 
ATOM   1077 N  NZ  . LYS B 1 44 ? 19.05822  24.04600 25.13188 1.000 48.32088 ? 44  LYS B NZ  1 
ATOM   1078 N  N   . LEU B 1 45 ? 18.50388  18.45545 22.62514 1.000 20.83364 ? 45  LEU B N   1 
ATOM   1079 C  CA  . LEU B 1 45 ? 17.75140  17.27479 23.03449 1.000 24.33594 ? 45  LEU B CA  1 
ATOM   1080 C  C   . LEU B 1 45 ? 18.30753  16.68489 24.32443 1.000 17.91066 ? 45  LEU B C   1 
ATOM   1081 O  O   . LEU B 1 45 ? 17.54476  16.34069 25.23314 1.000 22.70213 ? 45  LEU B O   1 
ATOM   1082 C  CB  . LEU B 1 45 ? 17.75580  16.23505 21.91182 1.000 16.48711 ? 45  LEU B CB  1 
ATOM   1083 C  CG  . LEU B 1 45 ? 16.83479  15.03094 22.11389 1.000 21.19181 ? 45  LEU B CG  1 
ATOM   1084 C  CD1 . LEU B 1 45 ? 15.39075  15.48289 22.20195 1.000 26.59096 ? 45  LEU B CD1 1 
ATOM   1085 C  CD2 . LEU B 1 45 ? 16.99856  14.02853 20.98033 1.000 17.96668 ? 45  LEU B CD2 1 
ATOM   1086 N  N   . GLU B 1 46 ? 19.63376  16.57582 24.43258 1.000 17.70451 ? 46  GLU B N   1 
ATOM   1087 C  CA  . GLU B 1 46 ? 20.22772  16.04909 25.65688 1.000 17.77490 ? 46  GLU B CA  1 
ATOM   1088 C  C   . GLU B 1 46 ? 19.92191  16.94320 26.84780 1.000 20.10496 ? 46  GLU B C   1 
ATOM   1089 O  O   . GLU B 1 46 ? 19.72222  16.45546 27.96447 1.000 23.74294 ? 46  GLU B O   1 
ATOM   1090 C  CB  . GLU B 1 46 ? 21.73697  15.89899 25.49533 1.000 20.08922 ? 46  GLU B CB  1 
ATOM   1091 C  CG  . GLU B 1 46 ? 22.15913  14.78615 24.56335 1.000 15.54937 ? 46  GLU B CG  1 
ATOM   1092 C  CD  . GLU B 1 46 ? 23.65178  14.55952 24.60862 1.000 30.74078 ? 46  GLU B CD  1 
ATOM   1093 O  OE1 . GLU B 1 46 ? 24.40289  15.54216 24.42115 1.000 20.87297 ? 46  GLU B OE1 1 
ATOM   1094 O  OE2 . GLU B 1 46 ? 24.07194  13.40357 24.83381 1.000 33.50374 ? 46  GLU B OE2 1 
ATOM   1095 N  N   . GLU B 1 47 ? 19.88229  18.25493 26.63118 1.000 21.40826 ? 47  GLU B N   1 
ATOM   1096 C  CA  . GLU B 1 47 ? 19.63992  19.17073 27.73774 1.000 24.61473 ? 47  GLU B CA  1 
ATOM   1097 C  C   . GLU B 1 47 ? 18.17113  19.18807 28.14381 1.000 29.35449 ? 47  GLU B C   1 
ATOM   1098 O  O   . GLU B 1 47 ? 17.85860  19.28717 29.33466 1.000 27.67091 ? 47  GLU B O   1 
ATOM   1099 C  CB  . GLU B 1 47 ? 20.12165  20.56785 27.36230 1.000 22.74597 ? 47  GLU B CB  1 
ATOM   1100 C  CG  . GLU B 1 47 ? 21.63153  20.65344 27.36248 1.000 20.59018 ? 47  GLU B CG  1 
ATOM   1101 C  CD  . GLU B 1 47 ? 22.14354  21.97787 26.85752 1.000 32.82539 ? 47  GLU B CD  1 
ATOM   1102 O  OE1 . GLU B 1 47 ? 21.32652  22.78653 26.36857 1.000 35.19118 ? 47  GLU B OE1 1 
ATOM   1103 O  OE2 . GLU B 1 47 ? 23.36804  22.20305 26.94601 1.000 28.68140 ? 47  GLU B OE2 1 
ATOM   1104 N  N   . GLU B 1 48 ? 17.25610  19.09242 27.17787 1.000 28.41629 ? 48  GLU B N   1 
ATOM   1105 C  CA  . GLU B 1 48 ? 15.83909  19.02506 27.52375 1.000 30.11552 ? 48  GLU B CA  1 
ATOM   1106 C  C   . GLU B 1 48 ? 15.50991  17.71545 28.22693 1.000 32.21965 ? 48  GLU B C   1 
ATOM   1107 O  O   . GLU B 1 48 ? 14.92522  17.71255 29.31633 1.000 29.96859 ? 48  GLU B O   1 
ATOM   1108 C  CB  . GLU B 1 48 ? 14.97064  19.19286 26.27747 1.000 37.66534 ? 48  GLU B CB  1 
ATOM   1109 C  CG  . GLU B 1 48 ? 13.52394  18.77042 26.51308 1.000 47.83631 ? 48  GLU B CG  1 
ATOM   1110 C  CD  . GLU B 1 48 ? 12.69115  18.75510 25.24692 1.000 46.66913 ? 48  GLU B CD  1 
ATOM   1111 O  OE1 . GLU B 1 48 ? 12.48566  19.83598 24.65525 1.000 46.08210 ? 48  GLU B OE1 1 
ATOM   1112 O  OE2 . GLU B 1 48 ? 12.25325  17.65859 24.83753 1.000 40.71857 ? 48  GLU B OE2 1 
ATOM   1113 N  N   . LEU B 1 49 ? 15.87804  16.58746 27.61855 1.000 34.12425 ? 49  LEU B N   1 
ATOM   1114 C  CA  . LEU B 1 49 ? 15.61138  15.29848 28.24187 1.000 31.87024 ? 49  LEU B CA  1 
ATOM   1115 C  C   . LEU B 1 49 ? 16.52209  15.03177 29.42977 1.000 36.00508 ? 49  LEU B C   1 
ATOM   1116 O  O   . LEU B 1 49 ? 16.20600  14.16569 30.25246 1.000 38.83096 ? 49  LEU B O   1 
ATOM   1117 C  CB  . LEU B 1 49 ? 15.75367  14.17028 27.21866 1.000 34.98822 ? 49  LEU B CB  1 
ATOM   1118 C  CG  . LEU B 1 49 ? 14.92337  14.27612 25.93754 1.000 37.07188 ? 49  LEU B CG  1 
ATOM   1119 C  CD1 . LEU B 1 49 ? 14.88903  12.92848 25.24168 1.000 28.47164 ? 49  LEU B CD1 1 
ATOM   1120 C  CD2 . LEU B 1 49 ? 13.51190  14.76951 26.22704 1.000 36.06130 ? 49  LEU B CD2 1 
ATOM   1121 N  N   . ASP B 1 50 ? 17.64542  15.74211 29.52509 1.000 34.36566 ? 50  ASP B N   1 
ATOM   1122 C  CA  . ASP B 1 50 ? 18.56791  15.62298 30.65180 1.000 34.48852 ? 50  ASP B CA  1 
ATOM   1123 C  C   . ASP B 1 50 ? 19.15534  14.21296 30.72526 1.000 38.31041 ? 50  ASP B C   1 
ATOM   1124 O  O   . ASP B 1 50 ? 19.07246  13.52933 31.74657 1.000 38.75073 ? 50  ASP B O   1 
ATOM   1125 C  CB  . ASP B 1 50 ? 17.87543  16.01789 31.96003 1.000 44.61511 ? 50  ASP B CB  1 
ATOM   1126 C  CG  . ASP B 1 50 ? 18.79554  16.75289 32.90865 1.000 38.90554 ? 50  ASP B CG  1 
ATOM   1127 O  OD1 . ASP B 1 50 ? 19.84765  17.24730 32.45154 1.000 42.39799 ? 50  ASP B OD1 1 
ATOM   1128 O  OD2 . ASP B 1 50 ? 18.45332  16.86077 34.10336 1.000 44.18071 ? 50  ASP B OD2 1 
ATOM   1129 N  N   . VAL B 1 51 ? 19.75842  13.77805 29.61786 1.000 30.90432 ? 51  VAL B N   1 
ATOM   1130 C  CA  . VAL B 1 51 ? 20.30739  12.43064 29.51837 1.000 30.38335 ? 51  VAL B CA  1 
ATOM   1131 C  C   . VAL B 1 51 ? 21.32016  12.41413 28.38214 1.000 26.94589 ? 51  VAL B C   1 
ATOM   1132 O  O   . VAL B 1 51 ? 21.25383  13.23173 27.46098 1.000 35.68263 ? 51  VAL B O   1 
ATOM   1133 C  CB  . VAL B 1 51 ? 19.17537  11.38995 29.30650 1.000 34.60032 ? 51  VAL B CB  1 
ATOM   1134 C  CG1 . VAL B 1 51 ? 18.46704  11.62380 27.97425 1.000 38.53168 ? 51  VAL B CG1 1 
ATOM   1135 C  CG2 . VAL B 1 51 ? 19.70008  9.96218  29.43111 1.000 33.56104 ? 51  VAL B CG2 1 
ATOM   1136 N  N   . VAL B 1 52 ? 22.27233  11.48821 28.45977 1.000 24.80242 ? 52  VAL B N   1 
ATOM   1137 C  CA  . VAL B 1 52 ? 23.25385  11.27483 27.40235 1.000 23.97630 ? 52  VAL B CA  1 
ATOM   1138 C  C   . VAL B 1 52 ? 22.67639  10.27588 26.41092 1.000 26.11270 ? 52  VAL B C   1 
ATOM   1139 O  O   . VAL B 1 52 ? 22.16392  9.22198  26.80755 1.000 24.20558 ? 52  VAL B O   1 
ATOM   1140 C  CB  . VAL B 1 52 ? 24.58475  10.76565 27.98191 1.000 25.63892 ? 52  VAL B CB  1 
ATOM   1141 C  CG1 . VAL B 1 52 ? 25.51866  10.30408 26.86841 1.000 28.78521 ? 52  VAL B CG1 1 
ATOM   1142 C  CG2 . VAL B 1 52 ? 25.23708  11.83037 28.84483 1.000 31.14554 ? 52  VAL B CG2 1 
ATOM   1143 N  N   . LEU B 1 53 ? 22.76921  10.59512 25.12017 1.000 20.62237 ? 53  LEU B N   1 
ATOM   1144 C  CA  . LEU B 1 53 ? 22.17965  9.76181  24.08051 1.000 18.51016 ? 53  LEU B CA  1 
ATOM   1145 C  C   . LEU B 1 53 ? 23.16938  8.81319  23.42313 1.000 19.34838 ? 53  LEU B C   1 
ATOM   1146 O  O   . LEU B 1 53 ? 22.77026  7.72982  22.98454 1.000 19.19418 ? 53  LEU B O   1 
ATOM   1147 C  CB  . LEU B 1 53 ? 21.53864  10.64253 23.00542 1.000 20.62510 ? 53  LEU B CB  1 
ATOM   1148 C  CG  . LEU B 1 53 ? 20.40081  11.50342 23.54279 1.000 23.39314 ? 53  LEU B CG  1 
ATOM   1149 C  CD1 . LEU B 1 53 ? 19.90804  12.47982 22.48817 1.000 29.36339 ? 53  LEU B CD1 1 
ATOM   1150 C  CD2 . LEU B 1 53 ? 19.27890  10.60877 24.04314 1.000 27.90156 ? 53  LEU B CD2 1 
ATOM   1151 N  N   . PHE B 1 54 ? 24.44239  9.18492  23.33405 1.000 25.28663 ? 54  PHE B N   1 
ATOM   1152 C  CA  . PHE B 1 54 ? 25.42757  8.32285  22.69684 1.000 29.28496 ? 54  PHE B CA  1 
ATOM   1153 C  C   . PHE B 1 54 ? 26.82313  8.79729  23.07375 1.000 34.24042 ? 54  PHE B C   1 
ATOM   1154 O  O   . PHE B 1 54 ? 27.00872  9.89919  23.59661 1.000 30.27657 ? 54  PHE B O   1 
ATOM   1155 C  CB  . PHE B 1 54 ? 25.23666  8.29113  21.17358 1.000 25.75308 ? 54  PHE B CB  1 
ATOM   1156 C  CG  . PHE B 1 54 ? 25.26429  9.64903  20.52559 1.000 27.04596 ? 54  PHE B CG  1 
ATOM   1157 C  CD1 . PHE B 1 54 ? 26.45331  10.34292 20.36942 1.000 33.42312 ? 54  PHE B CD1 1 
ATOM   1158 C  CD2 . PHE B 1 54 ? 24.09237  10.23557 20.08127 1.000 25.03372 ? 54  PHE B CD2 1 
ATOM   1159 C  CE1 . PHE B 1 54 ? 26.47218  11.59253 19.77576 1.000 30.01313 ? 54  PHE B CE1 1 
ATOM   1160 C  CE2 . PHE B 1 54 ? 24.10618  11.48631 19.49201 1.000 26.90798 ? 54  PHE B CE2 1 
ATOM   1161 C  CZ  . PHE B 1 54 ? 25.29867  12.16416 19.34105 1.000 23.76473 ? 54  PHE B CZ  1 
ATOM   1162 N  N   . ASP B 1 55 ? 27.80585  7.94043  22.79712 1.000 39.50164 ? 55  ASP B N   1 
ATOM   1163 C  CA  . ASP B 1 55 ? 29.21490  8.26200  22.97978 1.000 40.02677 ? 55  ASP B CA  1 
ATOM   1164 C  C   . ASP B 1 55 ? 29.96291  7.96727  21.68863 1.000 34.27796 ? 55  ASP B C   1 
ATOM   1165 O  O   . ASP B 1 55 ? 29.85957  6.86289  21.14542 1.000 35.04268 ? 55  ASP B O   1 
ATOM   1166 C  CB  . ASP B 1 55 ? 29.82855  7.46487  24.13529 1.000 32.07730 ? 55  ASP B CB  1 
ATOM   1167 C  CG  . ASP B 1 55 ? 28.93455  7.42779  25.35969 1.000 42.96798 ? 55  ASP B CG  1 
ATOM   1168 O  OD1 . ASP B 1 55 ? 28.80183  8.47350  26.02889 1.000 43.26921 ? 55  ASP B OD1 1 
ATOM   1169 O  OD2 . ASP B 1 55 ? 28.37172  6.35170  25.65605 1.000 47.37802 ? 55  ASP B OD2 1 
ATOM   1170 N  N   . ARG B 1 56 ? 30.70608  8.95378  21.19714 1.000 40.37072 ? 56  ARG B N   1 
ATOM   1171 C  CA  . ARG B 1 56 ? 31.56439  8.76489  20.03688 1.000 44.19933 ? 56  ARG B CA  1 
ATOM   1172 C  C   . ARG B 1 56 ? 32.91787  8.22763  20.47861 1.000 43.93280 ? 56  ARG B C   1 
ATOM   1173 O  O   . ARG B 1 56 ? 33.47461  8.67049  21.48774 1.000 51.91859 ? 56  ARG B O   1 
ATOM   1174 C  CB  . ARG B 1 56 ? 31.75614  10.07675 19.27227 1.000 46.68372 ? 56  ARG B CB  1 
ATOM   1175 C  CG  . ARG B 1 56 ? 30.56632  11.01813 19.30135 1.000 50.51726 ? 56  ARG B CG  1 
ATOM   1176 C  CD  . ARG B 1 56 ? 30.77414  12.12913 20.31539 1.000 44.20556 ? 56  ARG B CD  1 
ATOM   1177 N  NE  . ARG B 1 56 ? 29.92895  11.92414 21.48490 1.000 46.16138 ? 56  ARG B NE  1 
ATOM   1178 C  CZ  . ARG B 1 56 ? 28.88309  12.67856 21.79581 1.000 50.86000 ? 56  ARG B CZ  1 
ATOM   1179 N  NH1 . ARG B 1 56 ? 28.57939  13.76370 21.09992 1.000 29.56331 ? 56  ARG B NH1 1 
ATOM   1180 N  NH2 . ARG B 1 56 ? 28.11886  12.33302 22.82741 1.000 52.05000 ? 56  ARG B NH2 1 
ATOM   1181 N  N   . SER B 1 57 ? 33.44298  7.27618  19.71282 1.000 50.79322 ? 57  SER B N   1 
ATOM   1182 C  CA  . SER B 1 57 ? 34.74795  6.68552  19.99377 1.000 46.21542 ? 57  SER B CA  1 
ATOM   1183 C  C   . SER B 1 57 ? 35.18409  5.76837  18.85782 1.000 58.19288 ? 57  SER B C   1 
ATOM   1184 O  O   . SER B 1 57 ? 34.91652  4.56691  18.88218 1.000 60.77219 ? 57  SER B O   1 
ATOM   1185 C  CB  . SER B 1 57 ? 34.71856  5.90880  21.31009 1.000 42.73159 ? 57  SER B CB  1 
ATOM   1186 O  OG  . SER B 1 57 ? 34.93769  6.77607  22.40746 1.000 49.77809 ? 57  SER B OG  1 
ATOM   1187 N  N   . ARG B 1 60 ? 33.59073  4.37247  16.07667 1.000 55.52022 ? 60  ARG B N   1 
ATOM   1188 C  CA  . ARG B 1 60 ? 32.18130  4.58929  15.77251 1.000 54.05442 ? 60  ARG B CA  1 
ATOM   1189 C  C   . ARG B 1 60 ? 31.42631  5.14329  16.97996 1.000 52.92968 ? 60  ARG B C   1 
ATOM   1190 O  O   . ARG B 1 60 ? 32.02375  5.48843  17.99933 1.000 51.16619 ? 60  ARG B O   1 
ATOM   1191 C  CB  . ARG B 1 60 ? 31.53029  3.28850  15.29876 1.000 51.17036 ? 60  ARG B CB  1 
ATOM   1192 N  N   . THR B 1 61 ? 30.10584  5.22013  16.85919 1.000 44.66291 ? 61  THR B N   1 
ATOM   1193 C  CA  . THR B 1 61 ? 29.25608  5.80361  17.88524 1.000 40.03769 ? 61  THR B CA  1 
ATOM   1194 C  C   . THR B 1 61 ? 28.47444  4.71136  18.60099 1.000 42.30825 ? 61  THR B C   1 
ATOM   1195 O  O   . THR B 1 61 ? 27.94303  3.79425  17.96625 1.000 43.00572 ? 61  THR B O   1 
ATOM   1196 C  CB  . THR B 1 61 ? 28.29564  6.82870  17.27790 1.000 42.95286 ? 61  THR B CB  1 
ATOM   1197 O  OG1 . THR B 1 61 ? 29.04670  7.79642  16.53568 1.000 45.06534 ? 61  THR B OG1 1 
ATOM   1198 C  CG2 . THR B 1 61 ? 27.50858  7.53826  18.36591 1.000 36.63702 ? 61  THR B CG2 1 
ATOM   1199 N  N   . LYS B 1 62 ? 28.41373  4.81442  19.92639 1.000 40.08090 ? 62  LYS B N   1 
ATOM   1200 C  CA  . LYS B 1 62 ? 27.71122  3.85561  20.77015 1.000 35.80455 ? 62  LYS B CA  1 
ATOM   1201 C  C   . LYS B 1 62 ? 26.57789  4.58318  21.47918 1.000 33.88263 ? 62  LYS B C   1 
ATOM   1202 O  O   . LYS B 1 62 ? 26.81820  5.55967  22.19612 1.000 29.49079 ? 62  LYS B O   1 
ATOM   1203 C  CB  . LYS B 1 62 ? 28.66999  3.21929  21.77857 1.000 37.71848 ? 62  LYS B CB  1 
ATOM   1204 C  CG  . LYS B 1 62 ? 29.56563  2.12908  21.19531 1.000 44.62266 ? 62  LYS B CG  1 
ATOM   1205 C  CD  . LYS B 1 62 ? 29.80984  1.01484  22.20314 1.000 47.57277 ? 62  LYS B CD  1 
ATOM   1206 C  CE  . LYS B 1 62 ? 28.68638  -0.00567 22.20571 1.000 52.80348 ? 62  LYS B CE  1 
ATOM   1207 N  NZ  . LYS B 1 62 ? 28.87528  -1.04098 23.26467 1.000 51.63597 ? 62  LYS B NZ  1 
ATOM   1208 N  N   . PHE B 1 63 ? 25.35017  4.11271  21.27859 1.000 23.41067 ? 63  PHE B N   1 
ATOM   1209 C  CA  . PHE B 1 63 ? 24.17886  4.75503  21.85952 1.000 24.79804 ? 63  PHE B CA  1 
ATOM   1210 C  C   . PHE B 1 63 ? 23.92706  4.23796  23.26827 1.000 17.84530 ? 63  PHE B C   1 
ATOM   1211 O  O   . PHE B 1 63 ? 24.12739  3.05472  23.55094 1.000 23.42167 ? 63  PHE B O   1 
ATOM   1212 C  CB  . PHE B 1 63 ? 22.94457  4.51030  20.98785 1.000 21.47227 ? 63  PHE B CB  1 
ATOM   1213 C  CG  . PHE B 1 63 ? 22.91097  5.35201  19.74742 1.000 19.51750 ? 63  PHE B CG  1 
ATOM   1214 C  CD1 . PHE B 1 63 ? 23.68170  5.01825  18.64592 1.000 23.82783 ? 63  PHE B CD1 1 
ATOM   1215 C  CD2 . PHE B 1 63 ? 22.11978  6.48716  19.68870 1.000 17.72126 ? 63  PHE B CD2 1 
ATOM   1216 C  CE1 . PHE B 1 63 ? 23.65863  5.79914  17.51206 1.000 21.67091 ? 63  PHE B CE1 1 
ATOM   1217 C  CE2 . PHE B 1 63 ? 22.09204  7.27582  18.55053 1.000 17.72966 ? 63  PHE B CE2 1 
ATOM   1218 C  CZ  . PHE B 1 63 ? 22.86127  6.93290  17.46502 1.000 16.05898 ? 63  PHE B CZ  1 
ATOM   1219 N  N   . THR B 1 64 ? 23.48119  5.13135  24.14731 1.000 17.90620 ? 64  THR B N   1 
ATOM   1220 C  CA  . THR B 1 64 ? 23.08094  4.71757  25.48398 1.000 25.51855 ? 64  THR B CA  1 
ATOM   1221 C  C   . THR B 1 64 ? 21.75997  3.95962  25.40696 1.000 19.30268 ? 64  THR B C   1 
ATOM   1222 O  O   . THR B 1 64 ? 21.15977  3.80706  24.33856 1.000 16.81233 ? 64  THR B O   1 
ATOM   1223 C  CB  . THR B 1 64 ? 22.94394  5.92039  26.41166 1.000 19.19280 ? 64  THR B CB  1 
ATOM   1224 O  OG1 . THR B 1 64 ? 21.88170  6.76667  25.95045 1.000 19.42083 ? 64  THR B OG1 1 
ATOM   1225 C  CG2 . THR B 1 64 ? 24.24408  6.71203  26.46401 1.000 21.11591 ? 64  THR B CG2 1 
ATOM   1226 N  N   . ASN B 1 65 ? 21.28743  3.48714  26.56246 1.000 15.62196 ? 65  ASN B N   1 
ATOM   1227 C  CA  . ASN B 1 65 ? 20.00593  2.79102  26.57599 1.000 16.78868 ? 65  ASN B CA  1 
ATOM   1228 C  C   . ASN B 1 65 ? 18.86709  3.73413  26.20758 1.000 14.74504 ? 65  ASN B C   1 
ATOM   1229 O  O   . ASN B 1 65 ? 17.97424  3.36992  25.43479 1.000 15.33376 ? 65  ASN B O   1 
ATOM   1230 C  CB  . ASN B 1 65 ? 19.75781  2.16743  27.94753 1.000 17.29439 ? 65  ASN B CB  1 
ATOM   1231 C  CG  . ASN B 1 65 ? 20.72718  1.04516  28.26429 1.000 17.12014 ? 65  ASN B CG  1 
ATOM   1232 O  OD1 . ASN B 1 65 ? 21.15836  0.30818  27.37819 1.000 18.32415 ? 65  ASN B OD1 1 
ATOM   1233 N  ND2 . ASN B 1 65 ? 21.07626  0.91219  29.54209 1.000 19.16824 ? 65  ASN B ND2 1 
ATOM   1234 N  N   . VAL B 1 66 ? 18.87093  4.94724  26.76347 1.000 14.49176 ? 66  VAL B N   1 
ATOM   1235 C  CA  . VAL B 1 66 ? 17.86332  5.93015  26.38295 1.000 14.50033 ? 66  VAL B CA  1 
ATOM   1236 C  C   . VAL B 1 66 ? 18.07104  6.37796  24.94089 1.000 16.29881 ? 66  VAL B C   1 
ATOM   1237 O  O   . VAL B 1 66 ? 17.10752  6.53933  24.18382 1.000 15.68837 ? 66  VAL B O   1 
ATOM   1238 C  CB  . VAL B 1 66 ? 17.88070  7.12325  27.35479 1.000 17.81618 ? 66  VAL B CB  1 
ATOM   1239 C  CG1 . VAL B 1 66 ? 16.99733  8.24264  26.83626 1.000 19.67759 ? 66  VAL B CG1 1 
ATOM   1240 C  CG2 . VAL B 1 66 ? 17.41388  6.68422  28.72604 1.000 14.29381 ? 66  VAL B CG2 1 
ATOM   1241 N  N   . GLY B 1 67 ? 19.32621  6.58671  24.53798 1.000 15.42268 ? 67  GLY B N   1 
ATOM   1242 C  CA  . GLY B 1 67 ? 19.59320  6.94542  23.15369 1.000 15.13642 ? 67  GLY B CA  1 
ATOM   1243 C  C   . GLY B 1 67 ? 19.11014  5.89404  22.17272 1.000 14.52871 ? 67  GLY B C   1 
ATOM   1244 O  O   . GLY B 1 67 ? 18.55870  6.22108  21.11767 1.000 15.75112 ? 67  GLY B O   1 
ATOM   1245 N  N   . ARG B 1 68 ? 19.29085  4.61497  22.51198 1.000 13.99945 ? 68  ARG B N   1 
ATOM   1246 C  CA  . ARG B 1 68 ? 18.87731  3.55408  21.59751 1.000 13.46803 ? 68  ARG B CA  1 
ATOM   1247 C  C   . ARG B 1 68 ? 17.35872  3.47797  21.49110 1.000 15.14981 ? 68  ARG B C   1 
ATOM   1248 O  O   . ARG B 1 68 ? 16.81915  3.23427  20.40329 1.000 14.18986 ? 68  ARG B O   1 
ATOM   1249 C  CB  . ARG B 1 68 ? 19.46106  2.21011  22.04048 1.000 16.28205 ? 68  ARG B CB  1 
ATOM   1250 C  CG  . ARG B 1 68 ? 19.08563  1.04735  21.13998 1.000 20.44948 ? 68  ARG B CG  1 
ATOM   1251 C  CD  . ARG B 1 68 ? 20.16124  -0.03540 21.14287 1.000 25.06258 ? 68  ARG B CD  1 
ATOM   1252 N  NE  . ARG B 1 68 ? 21.38987  0.37961  20.47032 1.000 30.23585 ? 68  ARG B NE  1 
ATOM   1253 C  CZ  . ARG B 1 68 ? 21.53001  0.54048  19.15930 1.000 26.43538 ? 68  ARG B CZ  1 
ATOM   1254 N  NH1 . ARG B 1 68 ? 20.52704  0.33163  18.31979 1.000 20.61949 ? 68  ARG B NH1 1 
ATOM   1255 N  NH2 . ARG B 1 68 ? 22.71223  0.90934  18.67531 1.000 26.77310 ? 68  ARG B NH2 1 
ATOM   1256 N  N   . MET B 1 69 ? 16.65132  3.69650  22.60249 1.000 13.10178 ? 69  MET B N   1 
ATOM   1257 C  CA  . MET B 1 69 ? 15.19472  3.72369  22.54012 1.000 13.28647 ? 69  MET B CA  1 
ATOM   1258 C  C   . MET B 1 69 ? 14.70484  4.86829  21.66434 1.000 15.74861 ? 69  MET B C   1 
ATOM   1259 O  O   . MET B 1 69 ? 13.81801  4.67212  20.82766 1.000 15.71834 ? 69  MET B O   1 
ATOM   1260 C  CB  . MET B 1 69 ? 14.59670  3.79545  23.94880 1.000 16.69444 ? 69  MET B CB  1 
ATOM   1261 C  CG  . MET B 1 69 ? 13.07975  3.98506  23.96928 1.000 18.07616 ? 69  MET B CG  1 
ATOM   1262 S  SD  . MET B 1 69 ? 12.43803  4.79809  25.44703 1.000 21.25648 ? 69  MET B SD  1 
ATOM   1263 C  CE  . MET B 1 69 ? 12.40368  3.38851  26.55031 1.000 23.75910 ? 69  MET B CE  1 
ATOM   1264 N  N   . LEU B 1 70 ? 15.28408  6.06215  21.81617 1.000 14.85551 ? 70  LEU B N   1 
ATOM   1265 C  CA  . LEU B 1 70 ? 14.91315  7.16415  20.93122 1.000 16.45617 ? 70  LEU B CA  1 
ATOM   1266 C  C   . LEU B 1 70 ? 15.28406  6.85791  19.49021 1.000 15.54161 ? 70  LEU B C   1 
ATOM   1267 O  O   . LEU B 1 70 ? 14.52219  7.16401  18.56479 1.000 16.39733 ? 70  LEU B O   1 
ATOM   1268 C  CB  . LEU B 1 70 ? 15.58151  8.46312  21.37889 1.000 16.16717 ? 70  LEU B CB  1 
ATOM   1269 C  CG  . LEU B 1 70 ? 15.05223  9.08921  22.66819 1.000 20.45041 ? 70  LEU B CG  1 
ATOM   1270 C  CD1 . LEU B 1 70 ? 15.94852  10.23959 23.05842 1.000 26.27652 ? 70  LEU B CD1 1 
ATOM   1271 C  CD2 . LEU B 1 70 ? 13.63300  9.57475  22.49469 1.000 21.90446 ? 70  LEU B CD2 1 
ATOM   1272 N  N   . LEU B 1 71 ? 16.45341  6.25416  19.27888 1.000 14.25434 ? 71  LEU B N   1 
ATOM   1273 C  CA  . LEU B 1 71 ? 16.87613  5.91757  17.92419 1.000 15.43134 ? 71  LEU B CA  1 
ATOM   1274 C  C   . LEU B 1 71 ? 15.91122  4.93423  17.27515 1.000 16.43180 ? 71  LEU B C   1 
ATOM   1275 O  O   . LEU B 1 71 ? 15.41916  5.16590  16.16372 1.000 14.94626 ? 71  LEU B O   1 
ATOM   1276 C  CB  . LEU B 1 71 ? 18.29227  5.34651  17.95614 1.000 14.26097 ? 71  LEU B CB  1 
ATOM   1277 C  CG  . LEU B 1 71 ? 18.83716  4.81494  16.64008 1.000 12.95496 ? 71  LEU B CG  1 
ATOM   1278 C  CD1 . LEU B 1 71 ? 19.04790  5.94497  15.65319 1.000 16.00034 ? 71  LEU B CD1 1 
ATOM   1279 C  CD2 . LEU B 1 71 ? 20.13553  4.06733  16.91287 1.000 12.87775 ? 71  LEU B CD2 1 
ATOM   1280 N  N   . GLU B 1 72 ? 15.59983  3.84285  17.97295 1.000 13.53473 ? 72  GLU B N   1 
ATOM   1281 C  CA  . GLU B 1 72 ? 14.82547  2.77262  17.35808 1.000 16.99948 ? 72  GLU B CA  1 
ATOM   1282 C  C   . GLU B 1 72 ? 13.34560  3.13006  17.26026 1.000 16.47463 ? 72  GLU B C   1 
ATOM   1283 O  O   . GLU B 1 72 ? 12.73126  2.96981  16.19845 1.000 16.42076 ? 72  GLU B O   1 
ATOM   1284 C  CB  . GLU B 1 72 ? 15.04620  1.47447  18.13657 1.000 17.08007 ? 72  GLU B CB  1 
ATOM   1285 C  CG  . GLU B 1 72 ? 16.49295  0.99177  18.02100 1.000 13.05115 ? 72  GLU B CG  1 
ATOM   1286 C  CD  . GLU B 1 72 ? 16.73546  -0.33787 18.68835 1.000 16.29283 ? 72  GLU B CD  1 
ATOM   1287 O  OE1 . GLU B 1 72 ? 15.78694  -0.89751 19.27910 1.000 19.88598 ? 72  GLU B OE1 1 
ATOM   1288 O  OE2 . GLU B 1 72 ? 17.87548  -0.83391 18.59772 1.000 18.14819 ? 72  GLU B OE2 1 
ATOM   1289 N  N   . ARG B 1 73 ? 12.75436  3.62151  18.34958 1.000 15.19701 ? 73  ARG B N   1 
ATOM   1290 C  CA  . ARG B 1 73 ? 11.35830  4.04637  18.28204 1.000 14.28420 ? 73  ARG B CA  1 
ATOM   1291 C  C   . ARG B 1 73 ? 11.19216  5.29967  17.43323 1.000 14.48337 ? 73  ARG B C   1 
ATOM   1292 O  O   . ARG B 1 73 ? 10.11221  5.53424  16.87562 1.000 16.55829 ? 73  ARG B O   1 
ATOM   1293 C  CB  . ARG B 1 73 ? 10.80389  4.28664  19.68916 1.000 16.81684 ? 73  ARG B CB  1 
ATOM   1294 C  CG  . ARG B 1 73 ? 10.90145  3.08544  20.62165 1.000 21.62238 ? 73  ARG B CG  1 
ATOM   1295 C  CD  . ARG B 1 73 ? 9.52396   2.55547  21.01040 1.000 34.02750 ? 73  ARG B CD  1 
ATOM   1296 N  NE  . ARG B 1 73 ? 8.58615   3.60722  21.39273 1.000 33.26605 ? 73  ARG B NE  1 
ATOM   1297 C  CZ  . ARG B 1 73 ? 8.29507   3.94760  22.64256 1.000 30.22941 ? 73  ARG B CZ  1 
ATOM   1298 N  NH1 . ARG B 1 73 ? 8.88186   3.36330  23.67668 1.000 28.41203 ? 73  ARG B NH1 1 
ATOM   1299 N  NH2 . ARG B 1 73 ? 7.38433   4.89279  22.86162 1.000 23.08121 ? 73  ARG B NH2 1 
ATOM   1300 N  N   . GLY B 1 74 ? 12.23890  6.11912  17.32793 1.000 13.31251 ? 74  GLY B N   1 
ATOM   1301 C  CA  . GLY B 1 74 ? 12.16390  7.28457  16.46954 1.000 12.80456 ? 74  GLY B CA  1 
ATOM   1302 C  C   . GLY B 1 74 ? 12.08697  6.92322  15.00213 1.000 13.73451 ? 74  GLY B C   1 
ATOM   1303 O  O   . GLY B 1 74 ? 11.44946  7.62978  14.21913 1.000 14.72959 ? 74  GLY B O   1 
ATOM   1304 N  N   . ARG B 1 75 ? 12.72581  5.81996  14.60924 1.000 11.45436 ? 75  ARG B N   1 
ATOM   1305 C  CA  . ARG B 1 75 ? 12.64874  5.38265  13.21984 1.000 12.26159 ? 75  ARG B CA  1 
ATOM   1306 C  C   . ARG B 1 75 ? 11.23009  4.98210  12.83278 1.000 14.56084 ? 75  ARG B C   1 
ATOM   1307 O  O   . ARG B 1 75 ? 10.82482  5.15971  11.67451 1.000 13.97381 ? 75  ARG B O   1 
ATOM   1308 C  CB  . ARG B 1 75 ? 13.62046  4.22769  12.98844 1.000 12.71190 ? 75  ARG B CB  1 
ATOM   1309 C  CG  . ARG B 1 75 ? 15.04785  4.69365  12.75070 1.000 14.94727 ? 75  ARG B CG  1 
ATOM   1310 C  CD  . ARG B 1 75 ? 16.06348  3.60301  13.01742 1.000 12.71694 ? 75  ARG B CD  1 
ATOM   1311 N  NE  . ARG B 1 75 ? 17.41147  4.03288  12.65650 1.000 14.11960 ? 75  ARG B NE  1 
ATOM   1312 C  CZ  . ARG B 1 75 ? 18.52020  3.38048  12.98338 1.000 14.70325 ? 75  ARG B CZ  1 
ATOM   1313 N  NH1 . ARG B 1 75 ? 18.48585  2.29195  13.73534 1.000 12.81771 ? 75  ARG B NH1 1 
ATOM   1314 N  NH2 . ARG B 1 75 ? 19.69451  3.83499  12.54897 1.000 15.08352 ? 75  ARG B NH2 1 
ATOM   1315 N  N   . VAL B 1 76 ? 10.46694  4.42910  13.77726 1.000 14.08192 ? 76  VAL B N   1 
ATOM   1316 C  CA  . VAL B 1 76 ? 9.06649   4.12198  13.50279 1.000 14.05546 ? 76  VAL B CA  1 
ATOM   1317 C  C   . VAL B 1 76 ? 8.29371   5.40728  13.23165 1.000 14.99735 ? 76  VAL B C   1 
ATOM   1318 O  O   . VAL B 1 76 ? 7.47891   5.47883  12.30011 1.000 17.19430 ? 76  VAL B O   1 
ATOM   1319 C  CB  . VAL B 1 76 ? 8.45925   3.31666  14.66906 1.000 16.74964 ? 76  VAL B CB  1 
ATOM   1320 C  CG1 . VAL B 1 76 ? 6.96803   3.10209  14.45753 1.000 18.14443 ? 76  VAL B CG1 1 
ATOM   1321 C  CG2 . VAL B 1 76 ? 9.16494   1.97605  14.79981 1.000 15.59237 ? 76  VAL B CG2 1 
ATOM   1322 N  N   . LEU B 1 77 ? 8.56030   6.45109  14.02149 1.000 12.91614 ? 77  LEU B N   1 
ATOM   1323 C  CA  . LEU B 1 77 ? 7.90056   7.73694  13.80892 1.000 16.77873 ? 77  LEU B CA  1 
ATOM   1324 C  C   . LEU B 1 77 ? 8.29769   8.34623  12.47241 1.000 13.68132 ? 77  LEU B C   1 
ATOM   1325 O  O   . LEU B 1 77 ? 7.45413   8.90687  11.76132 1.000 15.61380 ? 77  LEU B O   1 
ATOM   1326 C  CB  . LEU B 1 77 ? 8.24144   8.70531  14.94369 1.000 15.21308 ? 77  LEU B CB  1 
ATOM   1327 C  CG  . LEU B 1 77 ? 7.75294   8.33058  16.33328 1.000 32.95000 ? 77  LEU B CG  1 
ATOM   1328 C  CD1 . LEU B 1 77 ? 7.91433   9.50115  17.30162 1.000 34.94813 ? 77  LEU B CD1 1 
ATOM   1329 C  CD2 . LEU B 1 77 ? 6.32763   7.87270  16.24257 1.000 40.39000 ? 77  LEU B CD2 1 
ATOM   1330 N  N   . LEU B 1 78 ? 9.58073   8.25934  12.11597 1.000 12.79523 ? 78  LEU B N   1 
ATOM   1331 C  CA  . LEU B 1 78 ? 10.01662  8.81392  10.83897 1.000 14.25246 ? 78  LEU B CA  1 
ATOM   1332 C  C   . LEU B 1 78 ? 9.32937   8.11084  9.67585  1.000 16.67542 ? 78  LEU B C   1 
ATOM   1333 O  O   . LEU B 1 78 ? 8.92538   8.75768  8.70279  1.000 15.81456 ? 78  LEU B O   1 
ATOM   1334 C  CB  . LEU B 1 78 ? 11.53695  8.71483  10.71199 1.000 13.59919 ? 78  LEU B CB  1 
ATOM   1335 C  CG  . LEU B 1 78 ? 12.33843  9.59248  11.67679 1.000 15.53811 ? 78  LEU B CG  1 
ATOM   1336 C  CD1 . LEU B 1 78 ? 13.79146  9.20171  11.61623 1.000 14.07269 ? 78  LEU B CD1 1 
ATOM   1337 C  CD2 . LEU B 1 78 ? 12.16811  11.06527 11.33798 1.000 16.23240 ? 78  LEU B CD2 1 
ATOM   1338 N  N   . GLU B 1 79 ? 9.17429   6.78583  9.76267  1.000 13.59601 ? 79  GLU B N   1 
ATOM   1339 C  CA  . GLU B 1 79 ? 8.45644   6.06769  8.71439  1.000 18.66941 ? 79  GLU B CA  1 
ATOM   1340 C  C   . GLU B 1 79 ? 7.01226   6.54882  8.61252  1.000 16.99704 ? 79  GLU B C   1 
ATOM   1341 O  O   . GLU B 1 79 ? 6.49762   6.77443  7.50943  1.000 15.15523 ? 79  GLU B O   1 
ATOM   1342 C  CB  . GLU B 1 79 ? 8.50125   4.55853  8.97508  1.000 15.59593 ? 79  GLU B CB  1 
ATOM   1343 C  CG  . GLU B 1 79 ? 7.89330   3.72582  7.84702  1.000 20.45736 ? 79  GLU B CG  1 
ATOM   1344 C  CD  . GLU B 1 79 ? 7.96951   2.22853  8.09728  1.000 33.54630 ? 79  GLU B CD  1 
ATOM   1345 O  OE1 . GLU B 1 79 ? 8.77282   1.80314  8.95457  1.000 30.21495 ? 79  GLU B OE1 1 
ATOM   1346 O  OE2 . GLU B 1 79 ? 7.22412   1.47556  7.43024  1.000 28.37573 ? 79  GLU B OE2 1 
ATOM   1347 N  N   . ALA B 1 80 ? 6.34373   6.71774  9.75500  1.000 12.75953 ? 80  ALA B N   1 
ATOM   1348 C  CA  . ALA B 1 80 ? 4.95226   7.16121  9.73938  1.000 15.50486 ? 80  ALA B CA  1 
ATOM   1349 C  C   . ALA B 1 80 ? 4.82852   8.57622  9.18953  1.000 15.09761 ? 80  ALA B C   1 
ATOM   1350 O  O   . ALA B 1 80 ? 3.85411   8.89603  8.49588  1.000 14.04869 ? 80  ALA B O   1 
ATOM   1351 C  CB  . ALA B 1 80 ? 4.35870   7.08006  11.14515 1.000 13.94932 ? 80  ALA B CB  1 
ATOM   1352 N  N   . ALA B 1 81 ? 5.80742   9.43533  9.48318  1.000 14.41972 ? 81  ALA B N   1 
ATOM   1353 C  CA  . ALA B 1 81 ? 5.78561   10.78519 8.93279  1.000 14.31552 ? 81  ALA B CA  1 
ATOM   1354 C  C   . ALA B 1 81 ? 5.97640   10.76188 7.42361  1.000 18.10309 ? 81  ALA B C   1 
ATOM   1355 O  O   . ALA B 1 81 ? 5.33852   11.53417 6.69835  1.000 14.88312 ? 81  ALA B O   1 
ATOM   1356 C  CB  . ALA B 1 81 ? 6.86125   11.64952 9.59090  1.000 18.15196 ? 81  ALA B CB  1 
ATOM   1357 N  N   . ASP B 1 82 ? 6.86000   9.89130  6.93256  1.000 14.32044 ? 82  ASP B N   1 
ATOM   1358 C  CA  . ASP B 1 82 ? 7.04070   9.76868  5.48990  1.000 20.67875 ? 82  ASP B CA  1 
ATOM   1359 C  C   . ASP B 1 82 ? 5.79377   9.20624  4.82081  1.000 16.39848 ? 82  ASP B C   1 
ATOM   1360 O  O   . ASP B 1 82 ? 5.40775   9.66248  3.73875  1.000 17.07666 ? 82  ASP B O   1 
ATOM   1361 C  CB  . ASP B 1 82 ? 8.25731   8.89726  5.18262  1.000 18.15306 ? 82  ASP B CB  1 
ATOM   1362 C  CG  . ASP B 1 82 ? 9.55572   9.67028  5.25698  1.000 37.16754 ? 82  ASP B CG  1 
ATOM   1363 O  OD1 . ASP B 1 82 ? 9.53150   10.84692 5.67423  1.000 37.65442 ? 82  ASP B OD1 1 
ATOM   1364 O  OD2 . ASP B 1 82 ? 10.59865  9.10719  4.87333  1.000 48.30141 ? 82  ASP B OD2 1 
ATOM   1365 N  N   . LYS B 1 83 ? 5.15112   8.21637  5.44623  1.000 17.02197 ? 83  LYS B N   1 
ATOM   1366 C  CA  . LYS B 1 83 ? 3.92070   7.67478  4.88079  1.000 17.36905 ? 83  LYS B CA  1 
ATOM   1367 C  C   . LYS B 1 83 ? 2.83577   8.74278  4.81424  1.000 17.13876 ? 83  LYS B C   1 
ATOM   1368 O  O   . LYS B 1 83 ? 2.14985   8.87556  3.79343  1.000 16.51614 ? 83  LYS B O   1 
ATOM   1369 C  CB  . LYS B 1 83 ? 3.44230   6.46787  5.69149  1.000 22.32432 ? 83  LYS B CB  1 
ATOM   1370 C  CG  . LYS B 1 83 ? 2.05789   5.97687  5.27774  1.000 26.12856 ? 83  LYS B CG  1 
ATOM   1371 C  CD  . LYS B 1 83 ? 1.79860   4.54189  5.71318  1.000 37.38339 ? 83  LYS B CD  1 
ATOM   1372 C  CE  . LYS B 1 83 ? 0.35542   4.35863  6.17101  1.000 43.76108 ? 83  LYS B CE  1 
ATOM   1373 N  NZ  . LYS B 1 83 ? 0.24326   4.13695  7.64203  1.000 43.96234 ? 83  LYS B NZ  1 
ATOM   1374 N  N   . LEU B 1 84 ? 2.68262   9.53471  5.88205  1.000 14.45093 ? 84  LEU B N   1 
ATOM   1375 C  CA  . LEU B 1 84 ? 1.68364   10.60279 5.87012  1.000 15.06117 ? 84  LEU B CA  1 
ATOM   1376 C  C   . LEU B 1 84 ? 1.98591   11.63263 4.78712  1.000 13.69869 ? 84  LEU B C   1 
ATOM   1377 O  O   . LEU B 1 84 ? 1.08302   12.05775 4.05531  1.000 14.18744 ? 84  LEU B O   1 
ATOM   1378 C  CB  . LEU B 1 84 ? 1.61009   11.27414 7.24439  1.000 13.10593 ? 84  LEU B CB  1 
ATOM   1379 C  CG  . LEU B 1 84 ? 0.66241   12.47089 7.38284  1.000 14.52075 ? 84  LEU B CG  1 
ATOM   1380 C  CD1 . LEU B 1 84 ? -0.73541  12.11020 6.91056  1.000 13.82746 ? 84  LEU B CD1 1 
ATOM   1381 C  CD2 . LEU B 1 84 ? 0.61669   12.97013 8.82660  1.000 15.59925 ? 84  LEU B CD2 1 
ATOM   1382 N  N   . THR B 1 85 ? 3.25123   12.04197 4.66504  1.000 12.63395 ? 85  THR B N   1 
ATOM   1383 C  CA  . THR B 1 85 ? 3.64006   12.95257 3.58842  1.000 16.75831 ? 85  THR B CA  1 
ATOM   1384 C  C   . THR B 1 85 ? 3.28054   12.37564 2.22407  1.000 18.88230 ? 85  THR B C   1 
ATOM   1385 O  O   . THR B 1 85 ? 2.68707   13.06077 1.37950  1.000 19.89477 ? 85  THR B O   1 
ATOM   1386 C  CB  . THR B 1 85 ? 5.14107   13.24827 3.66377  1.000 16.28693 ? 85  THR B CB  1 
ATOM   1387 O  OG1 . THR B 1 85 ? 5.45032   13.85628 4.92457  1.000 18.14903 ? 85  THR B OG1 1 
ATOM   1388 C  CG2 . THR B 1 85 ? 5.55252   14.18483 2.54392  1.000 24.99538 ? 85  THR B CG2 1 
ATOM   1389 N  N   . THR B 1 86 ? 3.63047   11.10808 1.99764  1.000 16.27898 ? 86  THR B N   1 
ATOM   1390 C  CA  . THR B 1 86 ? 3.32244   10.44633 0.73063  1.000 18.94992 ? 86  THR B CA  1 
ATOM   1391 C  C   . THR B 1 86 ? 1.82216   10.42604 0.46414  1.000 18.76090 ? 86  THR B C   1 
ATOM   1392 O  O   . THR B 1 86 ? 1.36864   10.73600 -0.64617 1.000 20.15687 ? 86  THR B O   1 
ATOM   1393 C  CB  . THR B 1 86 ? 3.87815   9.01972  0.74953  1.000 19.03295 ? 86  THR B CB  1 
ATOM   1394 O  OG1 . THR B 1 86 ? 5.30615   9.06240  0.65519  1.000 27.93476 ? 86  THR B OG1 1 
ATOM   1395 C  CG2 . THR B 1 86 ? 3.31646   8.20007  -0.40783 1.000 31.02033 ? 86  THR B CG2 1 
ATOM   1396 N  N   . ASP B 1 87 ? 1.03726   10.05020 1.47600  1.000 17.58828 ? 87  ASP B N   1 
ATOM   1397 C  CA  . ASP B 1 87 ? -0.40615  9.92173  1.30389  1.000 16.94333 ? 87  ASP B CA  1 
ATOM   1398 C  C   . ASP B 1 87 ? -1.05334  11.26830 1.01979  1.000 19.71521 ? 87  ASP B C   1 
ATOM   1399 O  O   . ASP B 1 87 ? -1.99618  11.35263 0.22252  1.000 16.63136 ? 87  ASP B O   1 
ATOM   1400 C  CB  . ASP B 1 87 ? -1.02929  9.29973  2.54960  1.000 18.87421 ? 87  ASP B CB  1 
ATOM   1401 C  CG  . ASP B 1 87 ? -0.69648  7.82573  2.70785  1.000 20.01359 ? 87  ASP B CG  1 
ATOM   1402 O  OD1 . ASP B 1 87 ? -0.20522  7.19867  1.74359  1.000 21.47267 ? 87  ASP B OD1 1 
ATOM   1403 O  OD2 . ASP B 1 87 ? -0.93409  7.29825  3.81132  1.000 21.55176 ? 87  ASP B OD2 1 
ATOM   1404 N  N   . ALA B 1 88 ? -0.58396  12.32663 1.69047  1.000 13.39442 ? 88  ALA B N   1 
ATOM   1405 C  CA  . ALA B 1 88 ? -1.14521  13.65407 1.46507  1.000 15.94849 ? 88  ALA B CA  1 
ATOM   1406 C  C   . ALA B 1 88 ? -0.81719  14.16339 0.06787  1.000 17.82644 ? 88  ALA B C   1 
ATOM   1407 O  O   . ALA B 1 88 ? -1.66338  14.78171 -0.58905 1.000 15.72873 ? 88  ALA B O   1 
ATOM   1408 C  CB  . ALA B 1 88 ? -0.63383  14.63196 2.52061  1.000 18.68497 ? 88  ALA B CB  1 
ATOM   1409 N  N   . GLU B 1 89 ? 0.40631   13.92232 -0.40430 1.000 18.93901 ? 89  GLU B N   1 
ATOM   1410 C  CA  . GLU B 1 89 ? 0.75048   14.35789 -1.75410 1.000 25.28974 ? 89  GLU B CA  1 
ATOM   1411 C  C   . GLU B 1 89 ? -0.06211  13.60203 -2.80073 1.000 21.33117 ? 89  GLU B C   1 
ATOM   1412 O  O   . GLU B 1 89 ? -0.47540  14.18328 -3.81334 1.000 23.29970 ? 89  GLU B O   1 
ATOM   1413 C  CB  . GLU B 1 89 ? 2.25028   14.18895 -2.00457 1.000 23.21028 ? 89  GLU B CB  1 
ATOM   1414 C  CG  . GLU B 1 89 ? 3.09229   15.37310 -1.53704 1.000 28.92453 ? 89  GLU B CG  1 
ATOM   1415 C  CD  . GLU B 1 89 ? 4.43115   14.95420 -0.96681 1.000 28.03928 ? 89  GLU B CD  1 
ATOM   1416 O  OE1 . GLU B 1 89 ? 4.73690   13.74559 -0.99231 1.000 39.53000 ? 89  GLU B OE1 1 
ATOM   1417 O  OE2 . GLU B 1 89 ? 5.18531   15.83493 -0.50620 1.000 33.23391 ? 89  GLU B OE2 1 
ATOM   1418 N  N   . ALA B 1 90 ? -0.30787  12.30963 -2.57038 1.000 20.45055 ? 90  ALA B N   1 
ATOM   1419 C  CA  . ALA B 1 90 ? -1.08589  11.51793 -3.51946 1.000 23.24408 ? 90  ALA B CA  1 
ATOM   1420 C  C   . ALA B 1 90 ? -2.50778  12.04835 -3.63883 1.000 20.14645 ? 90  ALA B C   1 
ATOM   1421 O  O   . ALA B 1 90 ? -3.04612  12.18293 -4.74478 1.000 20.08061 ? 90  ALA B O   1 
ATOM   1422 C  CB  . ALA B 1 90 ? -1.09401  10.05138 -3.09181 1.000 22.61266 ? 90  ALA B CB  1 
ATOM   1423 N  N   . LEU B 1 91 ? -3.14181  12.33613 -2.50177 1.000 17.11600 ? 91  LEU B N   1 
ATOM   1424 C  CA  . LEU B 1 91 ? -4.46311  12.94922 -2.53544 1.000 15.99086 ? 91  LEU B CA  1 
ATOM   1425 C  C   . LEU B 1 91 ? -4.41717  14.30916 -3.21998 1.000 16.16956 ? 91  LEU B C   1 
ATOM   1426 O  O   . LEU B 1 91 ? -5.31031  14.64458 -4.00469 1.000 16.00130 ? 91  LEU B O   1 
ATOM   1427 C  CB  . LEU B 1 91 ? -5.01678  13.07769 -1.11601 1.000 12.79196 ? 91  LEU B CB  1 
ATOM   1428 C  CG  . LEU B 1 91 ? -6.33383  13.84491 -1.00421 1.000 15.39189 ? 91  LEU B CG  1 
ATOM   1429 C  CD1 . LEU B 1 91 ? -7.40871  13.19594 -1.86473 1.000 18.66521 ? 91  LEU B CD1 1 
ATOM   1430 C  CD2 . LEU B 1 91 ? -6.77871  13.89621 0.44989  1.000 16.54752 ? 91  LEU B CD2 1 
ATOM   1431 N  N   . ALA B 1 92 ? -3.36980  15.09575 -2.95236 1.000 15.43507 ? 92  ALA B N   1 
ATOM   1432 C  CA  . ALA B 1 92 ? -3.27972  16.43928 -3.51913 1.000 19.28495 ? 92  ALA B CA  1 
ATOM   1433 C  C   . ALA B 1 92 ? -3.25971  16.40556 -5.04421 1.000 21.12816 ? 92  ALA B C   1 
ATOM   1434 O  O   . ALA B 1 92 ? -3.84678  17.27846 -5.69810 1.000 18.36447 ? 92  ALA B O   1 
ATOM   1435 C  CB  . ALA B 1 92 ? -2.04011  17.15575 -2.98268 1.000 17.92530 ? 92  ALA B CB  1 
ATOM   1436 N  N   . ARG B 1 93 ? -2.58453  15.41155 -5.63100 1.000 21.05917 ? 93  ARG B N   1 
ATOM   1437 C  CA  . ARG B 1 93 ? -2.56021  15.30025 -7.08797 1.000 24.15316 ? 93  ARG B CA  1 
ATOM   1438 C  C   . ARG B 1 93 ? -3.93932  15.02591 -7.66707 1.000 26.01325 ? 93  ARG B C   1 
ATOM   1439 O  O   . ARG B 1 93 ? -4.17966  15.32166 -8.84471 1.000 25.36908 ? 93  ARG B O   1 
ATOM   1440 C  CB  . ARG B 1 93 ? -1.59378  14.19953 -7.53621 1.000 28.94763 ? 93  ARG B CB  1 
ATOM   1441 C  CG  . ARG B 1 93 ? -0.21571  14.70657 -7.93544 1.000 41.08498 ? 93  ARG B CG  1 
ATOM   1442 C  CD  . ARG B 1 93 ? 0.78392   13.57152 -8.11874 1.000 42.91907 ? 93  ARG B CD  1 
ATOM   1443 N  NE  . ARG B 1 93 ? 0.83145   12.68584 -6.96186 1.000 49.00000 ? 93  ARG B NE  1 
ATOM   1444 C  CZ  . ARG B 1 93 ? 1.91187   12.47166 -6.22304 1.000 40.70052 ? 93  ARG B CZ  1 
ATOM   1445 N  NH1 . ARG B 1 93 ? 3.05542   13.09002 -6.47341 1.000 41.27954 ? 93  ARG B NH1 1 
ATOM   1446 N  NH2 . ARG B 1 93 ? 1.84154   11.62001 -5.20335 1.000 29.97880 ? 93  ARG B NH2 1 
ATOM   1447 N  N   . LEU B 1 94 ? -4.84617  14.46205 -6.87479 1.000 19.81399 ? 94  LEU B N   1 
ATOM   1448 C  CA  . LEU B 1 94 ? -6.20252  14.22444 -7.34112 1.000 21.54788 ? 94  LEU B CA  1 
ATOM   1449 C  C   . LEU B 1 94 ? -7.09876  15.44669 -7.18814 1.000 24.16925 ? 94  LEU B C   1 
ATOM   1450 O  O   . LEU B 1 94 ? -8.21413  15.44256 -7.71991 1.000 22.46281 ? 94  LEU B O   1 
ATOM   1451 C  CB  . LEU B 1 94 ? -6.80194  13.02862 -6.59578 1.000 16.21808 ? 94  LEU B CB  1 
ATOM   1452 C  CG  . LEU B 1 94 ? -5.97318  11.73802 -6.68604 1.000 18.04783 ? 94  LEU B CG  1 
ATOM   1453 C  CD1 . LEU B 1 94 ? -6.64619  10.59321 -5.93911 1.000 20.40957 ? 94  LEU B CD1 1 
ATOM   1454 C  CD2 . LEU B 1 94 ? -5.72496  11.34996 -8.13979 1.000 25.47746 ? 94  LEU B CD2 1 
ATOM   1455 N  N   . GLU B 1 95 ? -6.64031  16.48689 -6.49357 1.000 20.67601 ? 95  GLU B N   1 
ATOM   1456 C  CA  . GLU B 1 95 ? -7.46491  17.66055 -6.24121 1.000 23.91878 ? 95  GLU B CA  1 
ATOM   1457 C  C   . GLU B 1 95 ? -7.06421  18.79864 -7.17637 1.000 28.05287 ? 95  GLU B C   1 
ATOM   1458 O  O   . GLU B 1 95 ? -7.86560  19.68767 -7.46462 1.000 35.13702 ? 95  GLU B O   1 
ATOM   1459 C  CB  . GLU B 1 95 ? -7.34438  18.12038 -4.78223 1.000 24.16940 ? 95  GLU B CB  1 
ATOM   1460 C  CG  . GLU B 1 95 ? -7.30545  16.99685 -3.76219 1.000 31.70410 ? 95  GLU B CG  1 
ATOM   1461 C  CD  . GLU B 1 95 ? -8.67264  16.52488 -3.35774 1.000 33.60000 ? 95  GLU B CD  1 
ATOM   1462 O  OE1 . GLU B 1 95 ? -9.28041  15.79077 -4.15874 1.000 38.91000 ? 95  GLU B OE1 1 
ATOM   1463 O  OE2 . GLU B 1 95 ? -9.14610  16.88393 -2.26208 1.000 32.54997 ? 95  GLU B OE2 1 
HETATM 1464 P  P   . PO4 C 2 .  ? -3.36992  29.50009 2.42224  1.000 28.10667 ? 201 PO4 A P   1 
HETATM 1465 O  O1  . PO4 C 2 .  ? -2.19908  29.39131 1.46883  1.000 26.56055 ? 201 PO4 A O1  1 
HETATM 1466 O  O2  . PO4 C 2 .  ? -4.55035  30.06088 1.66433  1.000 28.96086 ? 201 PO4 A O2  1 
HETATM 1467 O  O3  . PO4 C 2 .  ? -3.73032  28.13902 2.96931  1.000 30.01897 ? 201 PO4 A O3  1 
HETATM 1468 O  O4  . PO4 C 2 .  ? -3.01779  30.40146 3.57616  1.000 23.30116 ? 201 PO4 A O4  1 
HETATM 1469 P  P   . PO4 D 2 .  ? 1.35330   18.03512 21.96845 1.000 65.40418 ? 202 PO4 A P   1 
HETATM 1470 O  O1  . PO4 D 2 .  ? 2.48906   17.48266 21.14062 1.000 52.66234 ? 202 PO4 A O1  1 
HETATM 1471 O  O2  . PO4 D 2 .  ? 1.08453   19.46602 21.56601 1.000 49.20890 ? 202 PO4 A O2  1 
HETATM 1472 O  O3  . PO4 D 2 .  ? 0.11708   17.19989 21.73296 1.000 54.09800 ? 202 PO4 A O3  1 
HETATM 1473 O  O4  . PO4 D 2 .  ? 1.72446   17.99137 23.43283 1.000 57.49909 ? 202 PO4 A O4  1 
HETATM 1474 P  P   . PO4 E 2 .  ? 25.04319  0.44362  21.38219 1.000 65.03987 ? 201 PO4 B P   1 
HETATM 1475 O  O1  . PO4 E 2 .  ? 24.94519  1.60002  20.41188 1.000 40.31470 ? 201 PO4 B O1  1 
HETATM 1476 O  O2  . PO4 E 2 .  ? 23.66410  -0.09834 21.67696 1.000 45.66562 ? 201 PO4 B O2  1 
HETATM 1477 O  O3  . PO4 E 2 .  ? 25.89469  -0.64402 20.76532 1.000 43.82465 ? 201 PO4 B O3  1 
HETATM 1478 O  O4  . PO4 E 2 .  ? 25.66592  0.90956  22.67759 1.000 43.59779 ? 201 PO4 B O4  1 
HETATM 1479 CL CL  . CL  F 3 .  ? 16.01004  0.46089  14.59771 1.000 16.20934 ? 202 CL  B CL  1 
HETATM 1480 O  O   . HOH G 4 .  ? 7.72843   23.12084 6.18922  1.000 36.14019 ? 301 HOH A O   1 
HETATM 1481 O  O   . HOH G 4 .  ? 13.64642  11.72359 33.22890 1.000 32.42209 ? 302 HOH A O   1 
HETATM 1482 O  O   . HOH G 4 .  ? -8.89212  31.97176 11.15228 1.000 30.53638 ? 303 HOH A O   1 
HETATM 1483 O  O   . HOH G 4 .  ? 8.44359   28.68862 -0.45203 1.000 24.52386 ? 304 HOH A O   1 
HETATM 1484 O  O   . HOH G 4 .  ? 6.51908   21.81551 8.61277  1.000 30.65967 ? 305 HOH A O   1 
HETATM 1485 O  O   . HOH G 4 .  ? 7.62878   27.86424 11.01775 1.000 32.41969 ? 306 HOH A O   1 
HETATM 1486 O  O   . HOH G 4 .  ? 10.88990  30.95928 3.19235  1.000 39.66704 ? 307 HOH A O   1 
HETATM 1487 O  O   . HOH G 4 .  ? 22.692    4.652    37.264   1.000 34.54024 ? 308 HOH A O   1 
HETATM 1488 O  O   . HOH G 4 .  ? 8.14581   15.88481 -0.79570 1.000 45.49525 ? 309 HOH A O   1 
HETATM 1489 O  O   . HOH G 4 .  ? 8.67464   14.83145 8.23842  1.000 30.41580 ? 310 HOH A O   1 
HETATM 1490 O  O   . HOH G 4 .  ? 20.64448  5.43570  28.97419 1.000 17.02374 ? 311 HOH A O   1 
HETATM 1491 O  O   . HOH G 4 .  ? -4.88418  32.73998 1.71115  1.000 27.12733 ? 312 HOH A O   1 
HETATM 1492 O  O   . HOH G 4 .  ? -11.34813 23.19856 11.66129 1.000 26.27946 ? 313 HOH A O   1 
HETATM 1493 O  O   . HOH G 4 .  ? 10.59186  5.93450  35.85873 1.000 25.21683 ? 314 HOH A O   1 
HETATM 1494 O  O   . HOH G 4 .  ? 0.80849   25.19491 -2.56616 1.000 26.89217 ? 315 HOH A O   1 
HETATM 1495 O  O   . HOH G 4 .  ? 7.83909   24.24509 12.11116 1.000 30.15262 ? 316 HOH A O   1 
HETATM 1496 O  O   . HOH G 4 .  ? -12.60301 17.66128 4.69333  1.000 37.44252 ? 317 HOH A O   1 
HETATM 1497 O  O   . HOH G 4 .  ? 5.96588   6.20018  20.44108 1.000 21.18661 ? 318 HOH A O   1 
HETATM 1498 O  O   . HOH G 4 .  ? 6.50404   24.76309 7.95625  1.000 21.91798 ? 319 HOH A O   1 
HETATM 1499 O  O   . HOH G 4 .  ? -0.38712  8.79544  11.36860 1.000 30.96945 ? 320 HOH A O   1 
HETATM 1500 O  O   . HOH G 4 .  ? -6.99908  29.85044 2.99803  1.000 27.85379 ? 321 HOH A O   1 
HETATM 1501 O  O   . HOH G 4 .  ? 7.94441   9.99487  31.97382 1.000 26.91109 ? 322 HOH A O   1 
HETATM 1502 O  O   . HOH G 4 .  ? -1.41889  22.19970 19.50962 1.000 24.84494 ? 323 HOH A O   1 
HETATM 1503 O  O   . HOH G 4 .  ? -2.83379  13.42856 19.56499 1.000 27.28337 ? 324 HOH A O   1 
HETATM 1504 O  O   . HOH G 4 .  ? 1.45040   28.87854 0.29328  1.000 16.19300 ? 325 HOH A O   1 
HETATM 1505 O  O   . HOH G 4 .  ? 4.42705   28.94888 13.96551 1.000 35.86848 ? 326 HOH A O   1 
HETATM 1506 O  O   . HOH G 4 .  ? -12.44811 19.91392 6.34604  1.000 30.45795 ? 327 HOH A O   1 
HETATM 1507 O  O   . HOH G 4 .  ? 11.14064  17.75866 9.54427  1.000 28.92870 ? 328 HOH A O   1 
HETATM 1508 O  O   . HOH G 4 .  ? 10.09486  3.52465  29.53636 1.000 22.40109 ? 329 HOH A O   1 
HETATM 1509 O  O   . HOH G 4 .  ? 16.236    1.007    38.805   1.000 23.06252 ? 330 HOH A O   1 
HETATM 1510 O  O   . HOH G 4 .  ? 5.93257   22.47452 18.70566 1.000 37.44878 ? 331 HOH A O   1 
HETATM 1511 O  O   . HOH G 4 .  ? -0.13556  7.27237  18.32063 1.000 24.37249 ? 332 HOH A O   1 
HETATM 1512 O  O   . HOH G 4 .  ? 8.66120   16.10057 23.07559 1.000 28.97448 ? 333 HOH A O   1 
HETATM 1513 O  O   . HOH G 4 .  ? 7.22531   4.50924  30.34374 1.000 34.26353 ? 334 HOH A O   1 
HETATM 1514 O  O   . HOH G 4 .  ? 6.781     31.281   11.820   1.000 24.81794 ? 335 HOH A O   1 
HETATM 1515 O  O   . HOH G 4 .  ? 1.41927   17.70083 -4.72508 1.000 35.95121 ? 336 HOH A O   1 
HETATM 1516 O  O   . HOH G 4 .  ? 2.71001   10.22767 26.85646 1.000 29.81681 ? 337 HOH A O   1 
HETATM 1517 O  O   . HOH G 4 .  ? -5.19059  10.36725 20.97609 1.000 39.76617 ? 338 HOH A O   1 
HETATM 1518 O  O   . HOH G 4 .  ? -1.94794  17.38701 13.87282 1.000 18.54073 ? 339 HOH A O   1 
HETATM 1519 O  O   . HOH G 4 .  ? -1.30342  36.58683 18.95826 1.000 32.11920 ? 340 HOH A O   1 
HETATM 1520 O  O   . HOH G 4 .  ? 16.34774  2.11093  41.11809 1.000 33.36223 ? 341 HOH A O   1 
HETATM 1521 O  O   . HOH G 4 .  ? -11.97725 22.42455 9.04158  1.000 24.97280 ? 342 HOH A O   1 
HETATM 1522 O  O   . HOH G 4 .  ? 8.84634   19.21548 18.28921 1.000 27.74775 ? 343 HOH A O   1 
HETATM 1523 O  O   . HOH G 4 .  ? -8.09510  10.22614 10.00694 1.000 27.51703 ? 344 HOH A O   1 
HETATM 1524 O  O   . HOH G 4 .  ? 0.75066   10.19475 24.21375 1.000 32.78868 ? 345 HOH A O   1 
HETATM 1525 O  O   . HOH G 4 .  ? -3.83715  20.15840 -1.99908 1.000 21.57996 ? 346 HOH A O   1 
HETATM 1526 O  O   . HOH G 4 .  ? 8.92056   20.10351 15.43120 1.000 21.03414 ? 347 HOH A O   1 
HETATM 1527 O  O   . HOH G 4 .  ? -7.31775  34.81192 12.46748 1.000 37.44320 ? 348 HOH A O   1 
HETATM 1528 O  O   . HOH G 4 .  ? -7.61831  19.13934 -0.58449 1.000 27.07446 ? 349 HOH A O   1 
HETATM 1529 O  O   . HOH G 4 .  ? 12.10132  33.45943 5.00843  1.000 43.87513 ? 350 HOH A O   1 
HETATM 1530 O  O   . HOH G 4 .  ? 0.48696   22.82118 21.58436 1.000 41.35625 ? 351 HOH A O   1 
HETATM 1531 O  O   . HOH G 4 .  ? -2.323    15.431   23.338   1.000 45.30544 ? 352 HOH A O   1 
HETATM 1532 O  O   . HOH G 4 .  ? 2.82063   25.25479 -4.02750 1.000 35.58496 ? 353 HOH A O   1 
HETATM 1533 O  O   . HOH G 4 .  ? 1.35755   6.43925  20.37154 1.000 25.16107 ? 354 HOH A O   1 
HETATM 1534 O  O   . HOH G 4 .  ? 0.62746   27.85913 -2.21112 1.000 32.14631 ? 355 HOH A O   1 
HETATM 1535 O  O   . HOH G 4 .  ? -10.96251 20.58815 -0.62758 1.000 37.11141 ? 356 HOH A O   1 
HETATM 1536 O  O   . HOH G 4 .  ? -6.694    9.607    12.061   1.000 19.82218 ? 357 HOH A O   1 
HETATM 1537 O  O   . HOH G 4 .  ? -1.43814  13.55310 21.95304 1.000 32.67420 ? 358 HOH A O   1 
HETATM 1538 O  O   . HOH G 4 .  ? 8.71901   1.71390  27.81309 1.000 34.43574 ? 359 HOH A O   1 
HETATM 1539 O  O   . HOH G 4 .  ? -2.97472  15.76888 19.55136 1.000 34.88292 ? 360 HOH A O   1 
HETATM 1540 O  O   . HOH G 4 .  ? 13.60344  28.64637 5.70317  1.000 47.42096 ? 361 HOH A O   1 
HETATM 1541 O  O   . HOH G 4 .  ? 5.877     6.720    32.221   1.000 31.92159 ? 362 HOH A O   1 
HETATM 1542 O  O   . HOH G 4 .  ? 3.10617   29.16716 -3.81529 1.000 34.23688 ? 363 HOH A O   1 
HETATM 1543 O  O   . HOH G 4 .  ? 1.31763   5.35965  16.20600 1.000 27.83766 ? 364 HOH A O   1 
HETATM 1544 O  O   . HOH G 4 .  ? 8.48681   26.81808 8.42604  1.000 35.27845 ? 365 HOH A O   1 
HETATM 1545 O  O   . HOH G 4 .  ? 5.26739   27.37348 -4.66162 1.000 35.87795 ? 366 HOH A O   1 
HETATM 1546 O  O   . HOH G 4 .  ? 10.49791  22.15564 14.78350 1.000 32.06372 ? 367 HOH A O   1 
HETATM 1547 O  O   . HOH H 4 .  ? 10.82609  17.24248 23.18549 1.000 42.68030 ? 301 HOH B O   1 
HETATM 1548 O  O   . HOH H 4 .  ? 20.01580  19.53342 12.77466 1.000 36.36096 ? 302 HOH B O   1 
HETATM 1549 O  O   . HOH H 4 .  ? -1.88491  3.90030  8.64639  1.000 56.26473 ? 303 HOH B O   1 
HETATM 1550 O  O   . HOH H 4 .  ? 26.11541  25.61017 13.55012 1.000 26.01113 ? 304 HOH B O   1 
HETATM 1551 O  O   . HOH H 4 .  ? 20.85984  0.51082  14.05072 1.000 31.96876 ? 305 HOH B O   1 
HETATM 1552 O  O   . HOH H 4 .  ? 1.40682   5.17248  9.65207  1.000 34.55035 ? 306 HOH B O   1 
HETATM 1553 O  O   . HOH H 4 .  ? 22.563    -0.774   30.754   1.000 37.81633 ? 307 HOH B O   1 
HETATM 1554 O  O   . HOH H 4 .  ? 2.72233   10.49000 -3.05877 1.000 23.08708 ? 308 HOH B O   1 
HETATM 1555 O  O   . HOH H 4 .  ? 18.336    -3.052   19.831   1.000 20.66379 ? 309 HOH B O   1 
HETATM 1556 O  O   . HOH H 4 .  ? 19.51210  20.22191 31.12873 1.000 40.70805 ? 310 HOH B O   1 
HETATM 1557 O  O   . HOH H 4 .  ? 10.31956  1.28240  24.37693 1.000 35.89301 ? 311 HOH B O   1 
HETATM 1558 O  O   . HOH H 4 .  ? 17.12073  4.23084  9.07447  1.000 20.91482 ? 312 HOH B O   1 
HETATM 1559 O  O   . HOH H 4 .  ? 7.97515   16.20382 20.21741 1.000 25.34573 ? 313 HOH B O   1 
HETATM 1560 O  O   . HOH H 4 .  ? -3.68793  9.42116  -0.42094 1.000 23.26647 ? 314 HOH B O   1 
HETATM 1561 O  O   . HOH H 4 .  ? 23.56478  0.55440  16.18707 1.000 28.89106 ? 315 HOH B O   1 
HETATM 1562 O  O   . HOH H 4 .  ? 30.79783  16.60419 7.29235  1.000 29.57383 ? 316 HOH B O   1 
HETATM 1563 O  O   . HOH H 4 .  ? 16.42644  1.17551  25.30166 1.000 24.71300 ? 317 HOH B O   1 
HETATM 1564 O  O   . HOH H 4 .  ? 8.97628   0.57951  11.34635 1.000 26.49115 ? 318 HOH B O   1 
HETATM 1565 O  O   . HOH H 4 .  ? -2.54312  10.36824 -6.70404 1.000 29.21126 ? 319 HOH B O   1 
HETATM 1566 O  O   . HOH H 4 .  ? 1.41664   7.73130  8.81829  1.000 26.83364 ? 320 HOH B O   1 
HETATM 1567 O  O   . HOH H 4 .  ? 13.11323  -1.45565 19.10561 1.000 31.81614 ? 321 HOH B O   1 
HETATM 1568 O  O   . HOH H 4 .  ? -4.11285  19.78015 -4.59204 1.000 32.66149 ? 322 HOH B O   1 
HETATM 1569 O  O   . HOH H 4 .  ? 12.46805  4.74571  9.49194  1.000 22.23318 ? 323 HOH B O   1 
HETATM 1570 O  O   . HOH H 4 .  ? 5.31360   11.59977 -2.64459 1.000 35.85180 ? 324 HOH B O   1 
HETATM 1571 O  O   . HOH H 4 .  ? 6.504     -0.992   8.560    1.000 36.45664 ? 325 HOH B O   1 
HETATM 1572 O  O   . HOH H 4 .  ? 5.71962   3.53589  11.25013 1.000 21.93722 ? 326 HOH B O   1 
HETATM 1573 O  O   . HOH H 4 .  ? 16.68253  19.25475 19.35318 1.000 24.01818 ? 327 HOH B O   1 
HETATM 1574 O  O   . HOH H 4 .  ? 15.45559  20.12467 15.18309 1.000 30.03161 ? 328 HOH B O   1 
HETATM 1575 O  O   . HOH H 4 .  ? 17.72553  21.66080 16.00191 1.000 45.61877 ? 329 HOH B O   1 
HETATM 1576 O  O   . HOH H 4 .  ? 7.56911   4.94658  18.07518 1.000 29.48361 ? 330 HOH B O   1 
HETATM 1577 O  O   . HOH H 4 .  ? 6.11873   6.68588  2.05355  1.000 32.76042 ? 331 HOH B O   1 
HETATM 1578 O  O   . HOH H 4 .  ? 17.59465  27.00350 18.94436 1.000 43.47953 ? 332 HOH B O   1 
HETATM 1579 O  O   . HOH H 4 .  ? 11.75058  18.42375 12.51966 1.000 18.73083 ? 333 HOH B O   1 
HETATM 1580 O  O   . HOH H 4 .  ? 24.50067  23.63577 8.07904  1.000 31.07182 ? 334 HOH B O   1 
HETATM 1581 O  O   . HOH H 4 .  ? 9.54842   18.01850 13.96782 1.000 16.38544 ? 335 HOH B O   1 
HETATM 1582 O  O   . HOH H 4 .  ? 7.12214   5.32590  5.01602  1.000 25.45789 ? 336 HOH B O   1 
HETATM 1583 O  O   . HOH H 4 .  ? 21.04503  23.18111 14.29800 1.000 36.35956 ? 337 HOH B O   1 
HETATM 1584 O  O   . HOH H 4 .  ? -2.88555  5.04203  3.67594  1.000 32.19109 ? 338 HOH B O   1 
HETATM 1585 O  O   . HOH H 4 .  ? 12.847    0.417    14.653   1.000 19.77086 ? 339 HOH B O   1 
HETATM 1586 O  O   . HOH H 4 .  ? 15.39239  7.92155  14.69863 1.000 18.63166 ? 340 HOH B O   1 
HETATM 1587 O  O   . HOH H 4 .  ? 23.27979  3.33466  28.89626 1.000 20.33493 ? 341 HOH B O   1 
HETATM 1588 O  O   . HOH H 4 .  ? 22.90316  4.42322  5.23068  1.000 27.45116 ? 342 HOH B O   1 
HETATM 1589 O  O   . HOH H 4 .  ? 26.20368  0.92240  17.60618 1.000 38.99727 ? 343 HOH B O   1 
HETATM 1590 O  O   . HOH H 4 .  ? -5.02019  9.46322  -2.76569 1.000 26.15052 ? 344 HOH B O   1 
HETATM 1591 O  O   . HOH H 4 .  ? 4.28781   3.88450  9.06586  1.000 28.33547 ? 345 HOH B O   1 
HETATM 1592 O  O   . HOH H 4 .  ? 11.857    -0.516   17.195   1.000 24.83726 ? 346 HOH B O   1 
HETATM 1593 O  O   . HOH H 4 .  ? 6.35839   0.72266  11.59472 1.000 34.64057 ? 347 HOH B O   1 
HETATM 1594 O  O   . HOH H 4 .  ? 4.32474   5.96789  14.61524 1.000 38.75908 ? 348 HOH B O   1 
HETATM 1595 O  O   . HOH H 4 .  ? 14.83806  0.14117  23.14626 1.000 34.47419 ? 349 HOH B O   1 
HETATM 1596 O  O   . HOH H 4 .  ? 2.79649   7.87688  -3.59614 1.000 33.80979 ? 350 HOH B O   1 
HETATM 1597 O  O   . HOH H 4 .  ? 12.64638  20.89526 13.08382 1.000 31.95672 ? 351 HOH B O   1 
HETATM 1598 O  O   . HOH H 4 .  ? 3.58347   3.85197  13.28735 1.000 32.15476 ? 352 HOH B O   1 
HETATM 1599 O  O   . HOH H 4 .  ? 5.18396   0.16926  15.19826 1.000 33.59145 ? 353 HOH B O   1 
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