data_9IND
# 
_entry.id   9IND 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.399 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9IND         pdb_00009ind 10.2210/pdb9ind/pdb 
WWPDB D_1300049218 ?            ?                   
EMDB  EMD-60703    ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-01-22 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  ? 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9IND 
_pdbx_database_status.recvd_initial_deposition_date   2024-07-06 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBC 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        EMDB 
_pdbx_database_related.details        'Integrin alpha-v beta-8 in complex with the Fab of 130H2' 
_pdbx_database_related.db_id          EMD-60703 
_pdbx_database_related.content_type   'associated EM volume' 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              abing0811@xmu.edu.cn 
_pdbx_contact_author.name_first         Qingbing 
_pdbx_contact_author.name_last          Zheng 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-7516-9965 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Sun, H.'   1 ? 
'Zheng, Q.' 2 ? 
'Gui, X.'   3 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   ? 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'J Exp Clin Cancer Res' 
_citation.journal_id_ASTM           ? 
_citation.journal_id_CSD            ? 
_citation.journal_id_ISSN           1756-9966 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            44 
_citation.language                  ? 
_citation.page_first                1 
_citation.page_last                 1 
_citation.title                     
;Specifically blocking alpha v beta 8-mediated TGF-beta signaling to reverse immunosuppression by modulating macrophage polarization.
;
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1186/s13046-024-03250-1 
_citation.pdbx_database_id_PubMed   39743547 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Guo, C.'   1  ? 
primary 'Sun, H.'   2  ? 
primary 'Du, Y.'    3  ? 
primary 'Dai, X.'   4  ? 
primary 'Pang, Y.'  5  ? 
primary 'Han, Z.'   6  ? 
primary 'Xiong, X.' 7  ? 
primary 'Li, S.'    8  ? 
primary 'Zhang, J.' 9  ? 
primary 'Zheng, Q.' 10 ? 
primary 'Gui, X.'   11 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Integrin alpha-V heavy chain' 47991.176 1 ? ? ? ? 
2 polymer     man 'The heavy chain of 130H2-Fab' 13290.723 1 ? ? ? ? 
3 polymer     man 'The light chain of 130H2-Fab' 11332.628 1 ? ? ? ? 
4 polymer     man 'Integrin beta-8' 39304.863 1 ? ? ? ? 
5 branched    man 
;alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
;
910.823   1 ? ? ? ? 
6 non-polymer syn 2-acetamido-2-deoxy-beta-D-glucopyranose 221.208   4 ? ? ? ? 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;FNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDY
AKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFS
IDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFV
SGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQ
RASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSM
PPSFGYSMKGATDIDKNGWPDLIVGAFGVDRAILYRARPV
;
;FNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDY
AKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFS
IDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFV
SGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQ
RASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSM
PPSFGYSMKGATDIDKNGWPDLIVGAFGVDRAILYRARPV
;
A ? 
2 'polypeptide(L)' no no 
;EVQLVQSGAEVKKPGASVKVSCKASGYTFTNYGINWVRQAPGQGLEWMGYFYIGNGYTEYNEKFKGRVTMTSDTSTSTVY
MELSSLRSEDTAVYYCALNYFGSRKFDYWGQGTTVTVSS
;
;EVQLVQSGAEVKKPGASVKVSCKASGYTFTNYGINWVRQAPGQGLEWMGYFYIGNGYTEYNEKFKGRVTMTSDTSTSTVY
MELSSLRSEDTAVYYCALNYFGSRKFDYWGQGTTVTVSS
;
H ? 
3 'polypeptide(L)' no no 
;EIVLTQSPATLSLSPGERATLSCRASQNIITNLHWYQQKPGQAPRLLIKYASQSISGIPARFSGSGSGTDFTLTISSLEP
EDFAVYFCQQSDDWPLTFGQGTKL
;
;EIVLTQSPATLSLSPGERATLSCRASQNIITNLHWYQQKPGQAPRLLIKYASQSISGIPARFSGSGSGTDFTLTISSLEP
EDFAVYFCQQSDDWPLTFGQGTKL
;
L ? 
4 'polypeptide(L)' no no 
;NEINTQVTPGEVSIQLRPGAEANFMLKVHPLKKYPVDLYYLVDVSASMHNNIEKLNSVGNDLSRKMAFFSRDFRLGFGSY
VDKTVSPYISIHPERIHNQCSDYNLDCMPPHGYIHVLSLTENITEFEKAVHRQKISGNIDTPEGGFDAMLQAAVCESHIG
WRKEAKRLLLVMTDQTSHLALDSKLAGIVVPNDGNCHLKNNVYVKSTTMEHPSLGQLSEKLIDNNINVIFAVQGKQFHWY
KDLLPLLPGTIAGEIESKAANLNNLVVEAYQKLISEVKVQVENQVQGIYFNITAICPDGSRKPGMEGCRNVTSNDEVLFN
VTVTMKKCDVTGGKNYAIIKPIGFNETAKIHI
;
;NEINTQVTPGEVSIQLRPGAEANFMLKVHPLKKYPVDLYYLVDVSASMHNNIEKLNSVGNDLSRKMAFFSRDFRLGFGSY
VDKTVSPYISIHPERIHNQCSDYNLDCMPPHGYIHVLSLTENITEFEKAVHRQKISGNIDTPEGGFDAMLQAAVCESHIG
WRKEAKRLLLVMTDQTSHLALDSKLAGIVVPNDGNCHLKNNVYVKSTTMEHPSLGQLSEKLIDNNINVIFAVQGKQFHWY
KDLLPLLPGTIAGEIESKAANLNNLVVEAYQKLISEVKVQVENQVQGIYFNITAICPDGSRKPGMEGCRNVTSNDEVLFN
VTVTMKKCDVTGGKNYAIIKPIGFNETAKIHI
;
B ? 
# 
_pdbx_entity_nonpoly.entity_id   6 
_pdbx_entity_nonpoly.name        2-acetamido-2-deoxy-beta-D-glucopyranose 
_pdbx_entity_nonpoly.comp_id     NAG 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   PHE n 
1 2   ASN n 
1 3   LEU n 
1 4   ASP n 
1 5   VAL n 
1 6   ASP n 
1 7   SER n 
1 8   PRO n 
1 9   ALA n 
1 10  GLU n 
1 11  TYR n 
1 12  SER n 
1 13  GLY n 
1 14  PRO n 
1 15  GLU n 
1 16  GLY n 
1 17  SER n 
1 18  TYR n 
1 19  PHE n 
1 20  GLY n 
1 21  PHE n 
1 22  ALA n 
1 23  VAL n 
1 24  ASP n 
1 25  PHE n 
1 26  PHE n 
1 27  VAL n 
1 28  PRO n 
1 29  SER n 
1 30  ALA n 
1 31  SER n 
1 32  SER n 
1 33  ARG n 
1 34  MET n 
1 35  PHE n 
1 36  LEU n 
1 37  LEU n 
1 38  VAL n 
1 39  GLY n 
1 40  ALA n 
1 41  PRO n 
1 42  LYS n 
1 43  ALA n 
1 44  ASN n 
1 45  THR n 
1 46  THR n 
1 47  GLN n 
1 48  PRO n 
1 49  GLY n 
1 50  ILE n 
1 51  VAL n 
1 52  GLU n 
1 53  GLY n 
1 54  GLY n 
1 55  GLN n 
1 56  VAL n 
1 57  LEU n 
1 58  LYS n 
1 59  CYS n 
1 60  ASP n 
1 61  TRP n 
1 62  SER n 
1 63  SER n 
1 64  THR n 
1 65  ARG n 
1 66  ARG n 
1 67  CYS n 
1 68  GLN n 
1 69  PRO n 
1 70  ILE n 
1 71  GLU n 
1 72  PHE n 
1 73  ASP n 
1 74  ALA n 
1 75  THR n 
1 76  GLY n 
1 77  ASN n 
1 78  ARG n 
1 79  ASP n 
1 80  TYR n 
1 81  ALA n 
1 82  LYS n 
1 83  ASP n 
1 84  ASP n 
1 85  PRO n 
1 86  LEU n 
1 87  GLU n 
1 88  PHE n 
1 89  LYS n 
1 90  SER n 
1 91  HIS n 
1 92  GLN n 
1 93  TRP n 
1 94  PHE n 
1 95  GLY n 
1 96  ALA n 
1 97  SER n 
1 98  VAL n 
1 99  ARG n 
1 100 SER n 
1 101 LYS n 
1 102 GLN n 
1 103 ASP n 
1 104 LYS n 
1 105 ILE n 
1 106 LEU n 
1 107 ALA n 
1 108 CYS n 
1 109 ALA n 
1 110 PRO n 
1 111 LEU n 
1 112 TYR n 
1 113 HIS n 
1 114 TRP n 
1 115 ARG n 
1 116 THR n 
1 117 GLU n 
1 118 MET n 
1 119 LYS n 
1 120 GLN n 
1 121 GLU n 
1 122 ARG n 
1 123 GLU n 
1 124 PRO n 
1 125 VAL n 
1 126 GLY n 
1 127 THR n 
1 128 CYS n 
1 129 PHE n 
1 130 LEU n 
1 131 GLN n 
1 132 ASP n 
1 133 GLY n 
1 134 THR n 
1 135 LYS n 
1 136 THR n 
1 137 VAL n 
1 138 GLU n 
1 139 TYR n 
1 140 ALA n 
1 141 PRO n 
1 142 CYS n 
1 143 ARG n 
1 144 SER n 
1 145 GLN n 
1 146 ASP n 
1 147 ILE n 
1 148 ASP n 
1 149 ALA n 
1 150 ASP n 
1 151 GLY n 
1 152 GLN n 
1 153 GLY n 
1 154 PHE n 
1 155 CYS n 
1 156 GLN n 
1 157 GLY n 
1 158 GLY n 
1 159 PHE n 
1 160 SER n 
1 161 ILE n 
1 162 ASP n 
1 163 PHE n 
1 164 THR n 
1 165 LYS n 
1 166 ALA n 
1 167 ASP n 
1 168 ARG n 
1 169 VAL n 
1 170 LEU n 
1 171 LEU n 
1 172 GLY n 
1 173 GLY n 
1 174 PRO n 
1 175 GLY n 
1 176 SER n 
1 177 PHE n 
1 178 TYR n 
1 179 TRP n 
1 180 GLN n 
1 181 GLY n 
1 182 GLN n 
1 183 LEU n 
1 184 ILE n 
1 185 SER n 
1 186 ASP n 
1 187 GLN n 
1 188 VAL n 
1 189 ALA n 
1 190 GLU n 
1 191 ILE n 
1 192 VAL n 
1 193 SER n 
1 194 LYS n 
1 195 TYR n 
1 196 ASP n 
1 197 PRO n 
1 198 ASN n 
1 199 VAL n 
1 200 TYR n 
1 201 SER n 
1 202 ILE n 
1 203 LYS n 
1 204 TYR n 
1 205 ASN n 
1 206 ASN n 
1 207 GLN n 
1 208 LEU n 
1 209 ALA n 
1 210 THR n 
1 211 ARG n 
1 212 THR n 
1 213 ALA n 
1 214 GLN n 
1 215 ALA n 
1 216 ILE n 
1 217 PHE n 
1 218 ASP n 
1 219 ASP n 
1 220 SER n 
1 221 TYR n 
1 222 LEU n 
1 223 GLY n 
1 224 TYR n 
1 225 SER n 
1 226 VAL n 
1 227 ALA n 
1 228 VAL n 
1 229 GLY n 
1 230 ASP n 
1 231 PHE n 
1 232 ASN n 
1 233 GLY n 
1 234 ASP n 
1 235 GLY n 
1 236 ILE n 
1 237 ASP n 
1 238 ASP n 
1 239 PHE n 
1 240 VAL n 
1 241 SER n 
1 242 GLY n 
1 243 VAL n 
1 244 PRO n 
1 245 ARG n 
1 246 ALA n 
1 247 ALA n 
1 248 ARG n 
1 249 THR n 
1 250 LEU n 
1 251 GLY n 
1 252 MET n 
1 253 VAL n 
1 254 TYR n 
1 255 ILE n 
1 256 TYR n 
1 257 ASP n 
1 258 GLY n 
1 259 LYS n 
1 260 ASN n 
1 261 MET n 
1 262 SER n 
1 263 SER n 
1 264 LEU n 
1 265 TYR n 
1 266 ASN n 
1 267 PHE n 
1 268 THR n 
1 269 GLY n 
1 270 GLU n 
1 271 GLN n 
1 272 MET n 
1 273 ALA n 
1 274 ALA n 
1 275 TYR n 
1 276 PHE n 
1 277 GLY n 
1 278 PHE n 
1 279 SER n 
1 280 VAL n 
1 281 ALA n 
1 282 ALA n 
1 283 THR n 
1 284 ASP n 
1 285 ILE n 
1 286 ASN n 
1 287 GLY n 
1 288 ASP n 
1 289 ASP n 
1 290 TYR n 
1 291 ALA n 
1 292 ASP n 
1 293 VAL n 
1 294 PHE n 
1 295 ILE n 
1 296 GLY n 
1 297 ALA n 
1 298 PRO n 
1 299 LEU n 
1 300 PHE n 
1 301 MET n 
1 302 ASP n 
1 303 ARG n 
1 304 GLY n 
1 305 SER n 
1 306 ASP n 
1 307 GLY n 
1 308 LYS n 
1 309 LEU n 
1 310 GLN n 
1 311 GLU n 
1 312 VAL n 
1 313 GLY n 
1 314 GLN n 
1 315 VAL n 
1 316 SER n 
1 317 VAL n 
1 318 SER n 
1 319 LEU n 
1 320 GLN n 
1 321 ARG n 
1 322 ALA n 
1 323 SER n 
1 324 GLY n 
1 325 ASP n 
1 326 PHE n 
1 327 GLN n 
1 328 THR n 
1 329 THR n 
1 330 LYS n 
1 331 LEU n 
1 332 ASN n 
1 333 GLY n 
1 334 PHE n 
1 335 GLU n 
1 336 VAL n 
1 337 PHE n 
1 338 ALA n 
1 339 ARG n 
1 340 PHE n 
1 341 GLY n 
1 342 SER n 
1 343 ALA n 
1 344 ILE n 
1 345 ALA n 
1 346 PRO n 
1 347 LEU n 
1 348 GLY n 
1 349 ASP n 
1 350 LEU n 
1 351 ASP n 
1 352 GLN n 
1 353 ASP n 
1 354 GLY n 
1 355 PHE n 
1 356 ASN n 
1 357 ASP n 
1 358 ILE n 
1 359 ALA n 
1 360 ILE n 
1 361 ALA n 
1 362 ALA n 
1 363 PRO n 
1 364 TYR n 
1 365 GLY n 
1 366 GLY n 
1 367 GLU n 
1 368 ASP n 
1 369 LYS n 
1 370 LYS n 
1 371 GLY n 
1 372 ILE n 
1 373 VAL n 
1 374 TYR n 
1 375 ILE n 
1 376 PHE n 
1 377 ASN n 
1 378 GLY n 
1 379 ARG n 
1 380 SER n 
1 381 THR n 
1 382 GLY n 
1 383 LEU n 
1 384 ASN n 
1 385 ALA n 
1 386 VAL n 
1 387 PRO n 
1 388 SER n 
1 389 GLN n 
1 390 ILE n 
1 391 LEU n 
1 392 GLU n 
1 393 GLY n 
1 394 GLN n 
1 395 TRP n 
1 396 ALA n 
1 397 ALA n 
1 398 ARG n 
1 399 SER n 
1 400 MET n 
1 401 PRO n 
1 402 PRO n 
1 403 SER n 
1 404 PHE n 
1 405 GLY n 
1 406 TYR n 
1 407 SER n 
1 408 MET n 
1 409 LYS n 
1 410 GLY n 
1 411 ALA n 
1 412 THR n 
1 413 ASP n 
1 414 ILE n 
1 415 ASP n 
1 416 LYS n 
1 417 ASN n 
1 418 GLY n 
1 419 TRP n 
1 420 PRO n 
1 421 ASP n 
1 422 LEU n 
1 423 ILE n 
1 424 VAL n 
1 425 GLY n 
1 426 ALA n 
1 427 PHE n 
1 428 GLY n 
1 429 VAL n 
1 430 ASP n 
1 431 ARG n 
1 432 ALA n 
1 433 ILE n 
1 434 LEU n 
1 435 TYR n 
1 436 ARG n 
1 437 ALA n 
1 438 ARG n 
1 439 PRO n 
1 440 VAL n 
2 1   GLU n 
2 2   VAL n 
2 3   GLN n 
2 4   LEU n 
2 5   VAL n 
2 6   GLN n 
2 7   SER n 
2 8   GLY n 
2 9   ALA n 
2 10  GLU n 
2 11  VAL n 
2 12  LYS n 
2 13  LYS n 
2 14  PRO n 
2 15  GLY n 
2 16  ALA n 
2 17  SER n 
2 18  VAL n 
2 19  LYS n 
2 20  VAL n 
2 21  SER n 
2 22  CYS n 
2 23  LYS n 
2 24  ALA n 
2 25  SER n 
2 26  GLY n 
2 27  TYR n 
2 28  THR n 
2 29  PHE n 
2 30  THR n 
2 31  ASN n 
2 32  TYR n 
2 33  GLY n 
2 34  ILE n 
2 35  ASN n 
2 36  TRP n 
2 37  VAL n 
2 38  ARG n 
2 39  GLN n 
2 40  ALA n 
2 41  PRO n 
2 42  GLY n 
2 43  GLN n 
2 44  GLY n 
2 45  LEU n 
2 46  GLU n 
2 47  TRP n 
2 48  MET n 
2 49  GLY n 
2 50  TYR n 
2 51  PHE n 
2 52  TYR n 
2 53  ILE n 
2 54  GLY n 
2 55  ASN n 
2 56  GLY n 
2 57  TYR n 
2 58  THR n 
2 59  GLU n 
2 60  TYR n 
2 61  ASN n 
2 62  GLU n 
2 63  LYS n 
2 64  PHE n 
2 65  LYS n 
2 66  GLY n 
2 67  ARG n 
2 68  VAL n 
2 69  THR n 
2 70  MET n 
2 71  THR n 
2 72  SER n 
2 73  ASP n 
2 74  THR n 
2 75  SER n 
2 76  THR n 
2 77  SER n 
2 78  THR n 
2 79  VAL n 
2 80  TYR n 
2 81  MET n 
2 82  GLU n 
2 83  LEU n 
2 84  SER n 
2 85  SER n 
2 86  LEU n 
2 87  ARG n 
2 88  SER n 
2 89  GLU n 
2 90  ASP n 
2 91  THR n 
2 92  ALA n 
2 93  VAL n 
2 94  TYR n 
2 95  TYR n 
2 96  CYS n 
2 97  ALA n 
2 98  LEU n 
2 99  ASN n 
2 100 TYR n 
2 101 PHE n 
2 102 GLY n 
2 103 SER n 
2 104 ARG n 
2 105 LYS n 
2 106 PHE n 
2 107 ASP n 
2 108 TYR n 
2 109 TRP n 
2 110 GLY n 
2 111 GLN n 
2 112 GLY n 
2 113 THR n 
2 114 THR n 
2 115 VAL n 
2 116 THR n 
2 117 VAL n 
2 118 SER n 
2 119 SER n 
3 1   GLU n 
3 2   ILE n 
3 3   VAL n 
3 4   LEU n 
3 5   THR n 
3 6   GLN n 
3 7   SER n 
3 8   PRO n 
3 9   ALA n 
3 10  THR n 
3 11  LEU n 
3 12  SER n 
3 13  LEU n 
3 14  SER n 
3 15  PRO n 
3 16  GLY n 
3 17  GLU n 
3 18  ARG n 
3 19  ALA n 
3 20  THR n 
3 21  LEU n 
3 22  SER n 
3 23  CYS n 
3 24  ARG n 
3 25  ALA n 
3 26  SER n 
3 27  GLN n 
3 28  ASN n 
3 29  ILE n 
3 30  ILE n 
3 31  THR n 
3 32  ASN n 
3 33  LEU n 
3 34  HIS n 
3 35  TRP n 
3 36  TYR n 
3 37  GLN n 
3 38  GLN n 
3 39  LYS n 
3 40  PRO n 
3 41  GLY n 
3 42  GLN n 
3 43  ALA n 
3 44  PRO n 
3 45  ARG n 
3 46  LEU n 
3 47  LEU n 
3 48  ILE n 
3 49  LYS n 
3 50  TYR n 
3 51  ALA n 
3 52  SER n 
3 53  GLN n 
3 54  SER n 
3 55  ILE n 
3 56  SER n 
3 57  GLY n 
3 58  ILE n 
3 59  PRO n 
3 60  ALA n 
3 61  ARG n 
3 62  PHE n 
3 63  SER n 
3 64  GLY n 
3 65  SER n 
3 66  GLY n 
3 67  SER n 
3 68  GLY n 
3 69  THR n 
3 70  ASP n 
3 71  PHE n 
3 72  THR n 
3 73  LEU n 
3 74  THR n 
3 75  ILE n 
3 76  SER n 
3 77  SER n 
3 78  LEU n 
3 79  GLU n 
3 80  PRO n 
3 81  GLU n 
3 82  ASP n 
3 83  PHE n 
3 84  ALA n 
3 85  VAL n 
3 86  TYR n 
3 87  PHE n 
3 88  CYS n 
3 89  GLN n 
3 90  GLN n 
3 91  SER n 
3 92  ASP n 
3 93  ASP n 
3 94  TRP n 
3 95  PRO n 
3 96  LEU n 
3 97  THR n 
3 98  PHE n 
3 99  GLY n 
3 100 GLN n 
3 101 GLY n 
3 102 THR n 
3 103 LYS n 
3 104 LEU n 
4 1   ASN n 
4 2   GLU n 
4 3   ILE n 
4 4   ASN n 
4 5   THR n 
4 6   GLN n 
4 7   VAL n 
4 8   THR n 
4 9   PRO n 
4 10  GLY n 
4 11  GLU n 
4 12  VAL n 
4 13  SER n 
4 14  ILE n 
4 15  GLN n 
4 16  LEU n 
4 17  ARG n 
4 18  PRO n 
4 19  GLY n 
4 20  ALA n 
4 21  GLU n 
4 22  ALA n 
4 23  ASN n 
4 24  PHE n 
4 25  MET n 
4 26  LEU n 
4 27  LYS n 
4 28  VAL n 
4 29  HIS n 
4 30  PRO n 
4 31  LEU n 
4 32  LYS n 
4 33  LYS n 
4 34  TYR n 
4 35  PRO n 
4 36  VAL n 
4 37  ASP n 
4 38  LEU n 
4 39  TYR n 
4 40  TYR n 
4 41  LEU n 
4 42  VAL n 
4 43  ASP n 
4 44  VAL n 
4 45  SER n 
4 46  ALA n 
4 47  SER n 
4 48  MET n 
4 49  HIS n 
4 50  ASN n 
4 51  ASN n 
4 52  ILE n 
4 53  GLU n 
4 54  LYS n 
4 55  LEU n 
4 56  ASN n 
4 57  SER n 
4 58  VAL n 
4 59  GLY n 
4 60  ASN n 
4 61  ASP n 
4 62  LEU n 
4 63  SER n 
4 64  ARG n 
4 65  LYS n 
4 66  MET n 
4 67  ALA n 
4 68  PHE n 
4 69  PHE n 
4 70  SER n 
4 71  ARG n 
4 72  ASP n 
4 73  PHE n 
4 74  ARG n 
4 75  LEU n 
4 76  GLY n 
4 77  PHE n 
4 78  GLY n 
4 79  SER n 
4 80  TYR n 
4 81  VAL n 
4 82  ASP n 
4 83  LYS n 
4 84  THR n 
4 85  VAL n 
4 86  SER n 
4 87  PRO n 
4 88  TYR n 
4 89  ILE n 
4 90  SER n 
4 91  ILE n 
4 92  HIS n 
4 93  PRO n 
4 94  GLU n 
4 95  ARG n 
4 96  ILE n 
4 97  HIS n 
4 98  ASN n 
4 99  GLN n 
4 100 CYS n 
4 101 SER n 
4 102 ASP n 
4 103 TYR n 
4 104 ASN n 
4 105 LEU n 
4 106 ASP n 
4 107 CYS n 
4 108 MET n 
4 109 PRO n 
4 110 PRO n 
4 111 HIS n 
4 112 GLY n 
4 113 TYR n 
4 114 ILE n 
4 115 HIS n 
4 116 VAL n 
4 117 LEU n 
4 118 SER n 
4 119 LEU n 
4 120 THR n 
4 121 GLU n 
4 122 ASN n 
4 123 ILE n 
4 124 THR n 
4 125 GLU n 
4 126 PHE n 
4 127 GLU n 
4 128 LYS n 
4 129 ALA n 
4 130 VAL n 
4 131 HIS n 
4 132 ARG n 
4 133 GLN n 
4 134 LYS n 
4 135 ILE n 
4 136 SER n 
4 137 GLY n 
4 138 ASN n 
4 139 ILE n 
4 140 ASP n 
4 141 THR n 
4 142 PRO n 
4 143 GLU n 
4 144 GLY n 
4 145 GLY n 
4 146 PHE n 
4 147 ASP n 
4 148 ALA n 
4 149 MET n 
4 150 LEU n 
4 151 GLN n 
4 152 ALA n 
4 153 ALA n 
4 154 VAL n 
4 155 CYS n 
4 156 GLU n 
4 157 SER n 
4 158 HIS n 
4 159 ILE n 
4 160 GLY n 
4 161 TRP n 
4 162 ARG n 
4 163 LYS n 
4 164 GLU n 
4 165 ALA n 
4 166 LYS n 
4 167 ARG n 
4 168 LEU n 
4 169 LEU n 
4 170 LEU n 
4 171 VAL n 
4 172 MET n 
4 173 THR n 
4 174 ASP n 
4 175 GLN n 
4 176 THR n 
4 177 SER n 
4 178 HIS n 
4 179 LEU n 
4 180 ALA n 
4 181 LEU n 
4 182 ASP n 
4 183 SER n 
4 184 LYS n 
4 185 LEU n 
4 186 ALA n 
4 187 GLY n 
4 188 ILE n 
4 189 VAL n 
4 190 VAL n 
4 191 PRO n 
4 192 ASN n 
4 193 ASP n 
4 194 GLY n 
4 195 ASN n 
4 196 CYS n 
4 197 HIS n 
4 198 LEU n 
4 199 LYS n 
4 200 ASN n 
4 201 ASN n 
4 202 VAL n 
4 203 TYR n 
4 204 VAL n 
4 205 LYS n 
4 206 SER n 
4 207 THR n 
4 208 THR n 
4 209 MET n 
4 210 GLU n 
4 211 HIS n 
4 212 PRO n 
4 213 SER n 
4 214 LEU n 
4 215 GLY n 
4 216 GLN n 
4 217 LEU n 
4 218 SER n 
4 219 GLU n 
4 220 LYS n 
4 221 LEU n 
4 222 ILE n 
4 223 ASP n 
4 224 ASN n 
4 225 ASN n 
4 226 ILE n 
4 227 ASN n 
4 228 VAL n 
4 229 ILE n 
4 230 PHE n 
4 231 ALA n 
4 232 VAL n 
4 233 GLN n 
4 234 GLY n 
4 235 LYS n 
4 236 GLN n 
4 237 PHE n 
4 238 HIS n 
4 239 TRP n 
4 240 TYR n 
4 241 LYS n 
4 242 ASP n 
4 243 LEU n 
4 244 LEU n 
4 245 PRO n 
4 246 LEU n 
4 247 LEU n 
4 248 PRO n 
4 249 GLY n 
4 250 THR n 
4 251 ILE n 
4 252 ALA n 
4 253 GLY n 
4 254 GLU n 
4 255 ILE n 
4 256 GLU n 
4 257 SER n 
4 258 LYS n 
4 259 ALA n 
4 260 ALA n 
4 261 ASN n 
4 262 LEU n 
4 263 ASN n 
4 264 ASN n 
4 265 LEU n 
4 266 VAL n 
4 267 VAL n 
4 268 GLU n 
4 269 ALA n 
4 270 TYR n 
4 271 GLN n 
4 272 LYS n 
4 273 LEU n 
4 274 ILE n 
4 275 SER n 
4 276 GLU n 
4 277 VAL n 
4 278 LYS n 
4 279 VAL n 
4 280 GLN n 
4 281 VAL n 
4 282 GLU n 
4 283 ASN n 
4 284 GLN n 
4 285 VAL n 
4 286 GLN n 
4 287 GLY n 
4 288 ILE n 
4 289 TYR n 
4 290 PHE n 
4 291 ASN n 
4 292 ILE n 
4 293 THR n 
4 294 ALA n 
4 295 ILE n 
4 296 CYS n 
4 297 PRO n 
4 298 ASP n 
4 299 GLY n 
4 300 SER n 
4 301 ARG n 
4 302 LYS n 
4 303 PRO n 
4 304 GLY n 
4 305 MET n 
4 306 GLU n 
4 307 GLY n 
4 308 CYS n 
4 309 ARG n 
4 310 ASN n 
4 311 VAL n 
4 312 THR n 
4 313 SER n 
4 314 ASN n 
4 315 ASP n 
4 316 GLU n 
4 317 VAL n 
4 318 LEU n 
4 319 PHE n 
4 320 ASN n 
4 321 VAL n 
4 322 THR n 
4 323 VAL n 
4 324 THR n 
4 325 MET n 
4 326 LYS n 
4 327 LYS n 
4 328 CYS n 
4 329 ASP n 
4 330 VAL n 
4 331 THR n 
4 332 GLY n 
4 333 GLY n 
4 334 LYS n 
4 335 ASN n 
4 336 TYR n 
4 337 ALA n 
4 338 ILE n 
4 339 ILE n 
4 340 LYS n 
4 341 PRO n 
4 342 ILE n 
4 343 GLY n 
4 344 PHE n 
4 345 ASN n 
4 346 GLU n 
4 347 THR n 
4 348 ALA n 
4 349 LYS n 
4 350 ILE n 
4 351 HIS n 
4 352 ILE n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 440 human ? 'ITGAV, MSK8, VNRA, VTNR' ? ? ? ? ? ? 'Homo sapiens' 9606  ? ? ? ? ? ? ? ? 
'Homo sapiens' 9606 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 119 ?     ? ?                         ? ? ? ? ? ? 'Mus musculus' 10090 ? ? ? ? ? ? ? ? 
'Homo sapiens' 9606 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
3 1 sample 'Biological sequence' 1 104 ?     ? ?                         ? ? ? ? ? ? 'Mus musculus' 10090 ? ? ? ? ? ? ? ? 
'Homo sapiens' 9606 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
4 1 sample 'Biological sequence' 1 352 human ? ITGB8                     ? ? ? ? ? ? 'Homo sapiens' 9606  ? ? ? ? ? ? ? ? 
'Homo sapiens' 9606 ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
_pdbx_entity_branch.entity_id   5 
_pdbx_entity_branch.type        oligosaccharide 
# 
loop_
_pdbx_entity_branch_descriptor.ordinal 
_pdbx_entity_branch_descriptor.entity_id 
_pdbx_entity_branch_descriptor.descriptor 
_pdbx_entity_branch_descriptor.type 
_pdbx_entity_branch_descriptor.program 
_pdbx_entity_branch_descriptor.program_version 
1 5 'DManpa1-3[DManpa1-6]DManpb1-4DGlcpNAcb1-4DGlcpNAcb1-'                                                      
'Glycam Condensed Sequence' GMML       1.0   
2 5 'WURCS=2.0/3,5,4/[a2122h-1b_1-5_2*NCC/3=O][a1122h-1b_1-5][a1122h-1a_1-5]/1-1-2-3-3/a4-b1_b4-c1_c3-d1_c6-e1' WURCS PDB2Glycan 
1.1.0 
3 5 '[]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-GlcpNAc]{[(4+1)][b-D-Manp]{[(3+1)][a-D-Manp]{}[(6+1)][a-D-Manp]{}}}}}' LINUCS PDB-CARE   
?     
# 
loop_
_pdbx_entity_branch_link.link_id 
_pdbx_entity_branch_link.entity_id 
_pdbx_entity_branch_link.entity_branch_list_num_1 
_pdbx_entity_branch_link.comp_id_1 
_pdbx_entity_branch_link.atom_id_1 
_pdbx_entity_branch_link.leaving_atom_id_1 
_pdbx_entity_branch_link.entity_branch_list_num_2 
_pdbx_entity_branch_link.comp_id_2 
_pdbx_entity_branch_link.atom_id_2 
_pdbx_entity_branch_link.leaving_atom_id_2 
_pdbx_entity_branch_link.value_order 
_pdbx_entity_branch_link.details 
1 5 2 NAG C1 O1 1 NAG O4 HO4 sing ? 
2 5 3 BMA C1 O1 2 NAG O4 HO4 sing ? 
3 5 4 MAN C1 O1 3 BMA O3 HO3 sing ? 
4 5 5 MAN C1 O1 3 BMA O6 HO6 sing ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking'           y ALANINE                                  ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking'           y ARGININE                                 ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking'           y ASPARAGINE                               ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking'           y 'ASPARTIC ACID'                          ? 'C4 H7 N O4'     133.103 
BMA 'D-saccharide, beta linking'  . beta-D-mannopyranose                     'beta-D-mannose; D-mannose; mannose' 'C6 H12 O6'      
180.156 
CYS 'L-peptide linking'           y CYSTEINE                                 ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking'           y GLUTAMINE                                ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking'           y 'GLUTAMIC ACID'                          ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'             y GLYCINE                                  ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking'           y HISTIDINE                                ? 'C6 H10 N3 O2 1' 156.162 
ILE 'L-peptide linking'           y ISOLEUCINE                               ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking'           y LEUCINE                                  ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking'           y LYSINE                                   ? 'C6 H15 N2 O2 1' 147.195 
MAN 'D-saccharide, alpha linking' . alpha-D-mannopyranose                    'alpha-D-mannose; D-mannose; mannose' 'C6 H12 O6' 
180.156 
MET 'L-peptide linking'           y METHIONINE                               ? 'C5 H11 N O2 S'  149.211 
NAG 'D-saccharide, beta linking'  . 2-acetamido-2-deoxy-beta-D-glucopyranose 
;N-acetyl-beta-D-glucosamine; 2-acetamido-2-deoxy-beta-D-glucose; 2-acetamido-2-deoxy-D-glucose; 2-acetamido-2-deoxy-glucose; N-ACETYL-D-GLUCOSAMINE
;
'C8 H15 N O6'    221.208 
PHE 'L-peptide linking'           y PHENYLALANINE                            ? 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking'           y PROLINE                                  ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking'           y SERINE                                   ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking'           y THREONINE                                ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking'           y TRYPTOPHAN                               ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking'           y TYROSINE                                 ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking'           y VALINE                                   ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_chem_comp_identifier.comp_id 
_pdbx_chem_comp_identifier.type 
_pdbx_chem_comp_identifier.program 
_pdbx_chem_comp_identifier.program_version 
_pdbx_chem_comp_identifier.identifier 
BMA 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DManpb                         
BMA 'COMMON NAME'                         GMML     1.0 b-D-mannopyranose              
BMA 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-Manp                       
BMA 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 Man                            
MAN 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DManpa                         
MAN 'COMMON NAME'                         GMML     1.0 a-D-mannopyranose              
MAN 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 a-D-Manp                       
MAN 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 Man                            
NAG 'CONDENSED IUPAC CARBOHYDRATE SYMBOL' GMML     1.0 DGlcpNAcb                      
NAG 'COMMON NAME'                         GMML     1.0 N-acetyl-b-D-glucopyranosamine 
NAG 'IUPAC CARBOHYDRATE SYMBOL'           PDB-CARE 1.0 b-D-GlcpNAc                    
NAG 'SNFG CARBOHYDRATE SYMBOL'            GMML     1.0 GlcNAc                         
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   PHE 1   1   1   PHE PHE A . n 
A 1 2   ASN 2   2   2   ASN ASN A . n 
A 1 3   LEU 3   3   3   LEU LEU A . n 
A 1 4   ASP 4   4   4   ASP ASP A . n 
A 1 5   VAL 5   5   5   VAL VAL A . n 
A 1 6   ASP 6   6   6   ASP ASP A . n 
A 1 7   SER 7   7   7   SER SER A . n 
A 1 8   PRO 8   8   8   PRO PRO A . n 
A 1 9   ALA 9   9   9   ALA ALA A . n 
A 1 10  GLU 10  10  10  GLU GLU A . n 
A 1 11  TYR 11  11  11  TYR TYR A . n 
A 1 12  SER 12  12  12  SER SER A . n 
A 1 13  GLY 13  13  13  GLY GLY A . n 
A 1 14  PRO 14  14  14  PRO PRO A . n 
A 1 15  GLU 15  15  15  GLU GLU A . n 
A 1 16  GLY 16  16  16  GLY GLY A . n 
A 1 17  SER 17  17  17  SER SER A . n 
A 1 18  TYR 18  18  18  TYR TYR A . n 
A 1 19  PHE 19  19  19  PHE PHE A . n 
A 1 20  GLY 20  20  20  GLY GLY A . n 
A 1 21  PHE 21  21  21  PHE PHE A . n 
A 1 22  ALA 22  22  22  ALA ALA A . n 
A 1 23  VAL 23  23  23  VAL VAL A . n 
A 1 24  ASP 24  24  24  ASP ASP A . n 
A 1 25  PHE 25  25  25  PHE PHE A . n 
A 1 26  PHE 26  26  26  PHE PHE A . n 
A 1 27  VAL 27  27  27  VAL VAL A . n 
A 1 28  PRO 28  28  28  PRO PRO A . n 
A 1 29  SER 29  29  29  SER SER A . n 
A 1 30  ALA 30  30  30  ALA ALA A . n 
A 1 31  SER 31  31  31  SER SER A . n 
A 1 32  SER 32  32  32  SER SER A . n 
A 1 33  ARG 33  33  33  ARG ARG A . n 
A 1 34  MET 34  34  34  MET MET A . n 
A 1 35  PHE 35  35  35  PHE PHE A . n 
A 1 36  LEU 36  36  36  LEU LEU A . n 
A 1 37  LEU 37  37  37  LEU LEU A . n 
A 1 38  VAL 38  38  38  VAL VAL A . n 
A 1 39  GLY 39  39  39  GLY GLY A . n 
A 1 40  ALA 40  40  40  ALA ALA A . n 
A 1 41  PRO 41  41  41  PRO PRO A . n 
A 1 42  LYS 42  42  42  LYS LYS A . n 
A 1 43  ALA 43  43  43  ALA ALA A . n 
A 1 44  ASN 44  44  44  ASN ASN A . n 
A 1 45  THR 45  45  45  THR THR A . n 
A 1 46  THR 46  46  46  THR THR A . n 
A 1 47  GLN 47  47  47  GLN GLN A . n 
A 1 48  PRO 48  48  48  PRO PRO A . n 
A 1 49  GLY 49  49  49  GLY GLY A . n 
A 1 50  ILE 50  50  50  ILE ILE A . n 
A 1 51  VAL 51  51  51  VAL VAL A . n 
A 1 52  GLU 52  52  52  GLU GLU A . n 
A 1 53  GLY 53  53  53  GLY GLY A . n 
A 1 54  GLY 54  54  54  GLY GLY A . n 
A 1 55  GLN 55  55  55  GLN GLN A . n 
A 1 56  VAL 56  56  56  VAL VAL A . n 
A 1 57  LEU 57  57  57  LEU LEU A . n 
A 1 58  LYS 58  58  58  LYS LYS A . n 
A 1 59  CYS 59  59  59  CYS CYS A . n 
A 1 60  ASP 60  60  60  ASP ASP A . n 
A 1 61  TRP 61  61  61  TRP TRP A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  SER 63  63  63  SER SER A . n 
A 1 64  THR 64  64  64  THR THR A . n 
A 1 65  ARG 65  65  65  ARG ARG A . n 
A 1 66  ARG 66  66  66  ARG ARG A . n 
A 1 67  CYS 67  67  67  CYS CYS A . n 
A 1 68  GLN 68  68  68  GLN GLN A . n 
A 1 69  PRO 69  69  69  PRO PRO A . n 
A 1 70  ILE 70  70  70  ILE ILE A . n 
A 1 71  GLU 71  71  71  GLU GLU A . n 
A 1 72  PHE 72  72  72  PHE PHE A . n 
A 1 73  ASP 73  73  73  ASP ASP A . n 
A 1 74  ALA 74  74  74  ALA ALA A . n 
A 1 75  THR 75  75  75  THR THR A . n 
A 1 76  GLY 76  76  76  GLY GLY A . n 
A 1 77  ASN 77  77  77  ASN ASN A . n 
A 1 78  ARG 78  78  78  ARG ARG A . n 
A 1 79  ASP 79  79  79  ASP ASP A . n 
A 1 80  TYR 80  80  80  TYR TYR A . n 
A 1 81  ALA 81  81  81  ALA ALA A . n 
A 1 82  LYS 82  82  82  LYS LYS A . n 
A 1 83  ASP 83  83  83  ASP ASP A . n 
A 1 84  ASP 84  84  84  ASP ASP A . n 
A 1 85  PRO 85  85  85  PRO PRO A . n 
A 1 86  LEU 86  86  86  LEU LEU A . n 
A 1 87  GLU 87  87  87  GLU GLU A . n 
A 1 88  PHE 88  88  88  PHE PHE A . n 
A 1 89  LYS 89  89  89  LYS LYS A . n 
A 1 90  SER 90  90  90  SER SER A . n 
A 1 91  HIS 91  91  91  HIS HIS A . n 
A 1 92  GLN 92  92  92  GLN GLN A . n 
A 1 93  TRP 93  93  93  TRP TRP A . n 
A 1 94  PHE 94  94  94  PHE PHE A . n 
A 1 95  GLY 95  95  95  GLY GLY A . n 
A 1 96  ALA 96  96  96  ALA ALA A . n 
A 1 97  SER 97  97  97  SER SER A . n 
A 1 98  VAL 98  98  98  VAL VAL A . n 
A 1 99  ARG 99  99  99  ARG ARG A . n 
A 1 100 SER 100 100 100 SER SER A . n 
A 1 101 LYS 101 101 101 LYS LYS A . n 
A 1 102 GLN 102 102 102 GLN GLN A . n 
A 1 103 ASP 103 103 103 ASP ASP A . n 
A 1 104 LYS 104 104 104 LYS LYS A . n 
A 1 105 ILE 105 105 105 ILE ILE A . n 
A 1 106 LEU 106 106 106 LEU LEU A . n 
A 1 107 ALA 107 107 107 ALA ALA A . n 
A 1 108 CYS 108 108 108 CYS CYS A . n 
A 1 109 ALA 109 109 109 ALA ALA A . n 
A 1 110 PRO 110 110 110 PRO PRO A . n 
A 1 111 LEU 111 111 111 LEU LEU A . n 
A 1 112 TYR 112 112 112 TYR TYR A . n 
A 1 113 HIS 113 113 113 HIS HIS A . n 
A 1 114 TRP 114 114 114 TRP TRP A . n 
A 1 115 ARG 115 115 115 ARG ARG A . n 
A 1 116 THR 116 116 116 THR THR A . n 
A 1 117 GLU 117 117 117 GLU GLU A . n 
A 1 118 MET 118 118 118 MET MET A . n 
A 1 119 LYS 119 119 119 LYS LYS A . n 
A 1 120 GLN 120 120 120 GLN GLN A . n 
A 1 121 GLU 121 121 121 GLU GLU A . n 
A 1 122 ARG 122 122 122 ARG ARG A . n 
A 1 123 GLU 123 123 123 GLU GLU A . n 
A 1 124 PRO 124 124 124 PRO PRO A . n 
A 1 125 VAL 125 125 125 VAL VAL A . n 
A 1 126 GLY 126 126 126 GLY GLY A . n 
A 1 127 THR 127 127 127 THR THR A . n 
A 1 128 CYS 128 128 128 CYS CYS A . n 
A 1 129 PHE 129 129 129 PHE PHE A . n 
A 1 130 LEU 130 130 130 LEU LEU A . n 
A 1 131 GLN 131 131 131 GLN GLN A . n 
A 1 132 ASP 132 132 132 ASP ASP A . n 
A 1 133 GLY 133 133 133 GLY GLY A . n 
A 1 134 THR 134 134 134 THR THR A . n 
A 1 135 LYS 135 135 135 LYS LYS A . n 
A 1 136 THR 136 136 136 THR THR A . n 
A 1 137 VAL 137 137 137 VAL VAL A . n 
A 1 138 GLU 138 138 138 GLU GLU A . n 
A 1 139 TYR 139 139 139 TYR TYR A . n 
A 1 140 ALA 140 140 140 ALA ALA A . n 
A 1 141 PRO 141 141 141 PRO PRO A . n 
A 1 142 CYS 142 142 142 CYS CYS A . n 
A 1 143 ARG 143 143 143 ARG ARG A . n 
A 1 144 SER 144 144 144 SER SER A . n 
A 1 145 GLN 145 145 145 GLN GLN A . n 
A 1 146 ASP 146 146 146 ASP ASP A . n 
A 1 147 ILE 147 147 147 ILE ILE A . n 
A 1 148 ASP 148 148 148 ASP ASP A . n 
A 1 149 ALA 149 149 149 ALA ALA A . n 
A 1 150 ASP 150 150 150 ASP ASP A . n 
A 1 151 GLY 151 151 151 GLY GLY A . n 
A 1 152 GLN 152 152 152 GLN GLN A . n 
A 1 153 GLY 153 153 153 GLY GLY A . n 
A 1 154 PHE 154 154 154 PHE PHE A . n 
A 1 155 CYS 155 155 155 CYS CYS A . n 
A 1 156 GLN 156 156 156 GLN GLN A . n 
A 1 157 GLY 157 157 157 GLY GLY A . n 
A 1 158 GLY 158 158 158 GLY GLY A . n 
A 1 159 PHE 159 159 159 PHE PHE A . n 
A 1 160 SER 160 160 160 SER SER A . n 
A 1 161 ILE 161 161 161 ILE ILE A . n 
A 1 162 ASP 162 162 162 ASP ASP A . n 
A 1 163 PHE 163 163 163 PHE PHE A . n 
A 1 164 THR 164 164 164 THR THR A . n 
A 1 165 LYS 165 165 165 LYS LYS A . n 
A 1 166 ALA 166 166 166 ALA ALA A . n 
A 1 167 ASP 167 167 167 ASP ASP A . n 
A 1 168 ARG 168 168 168 ARG ARG A . n 
A 1 169 VAL 169 169 169 VAL VAL A . n 
A 1 170 LEU 170 170 170 LEU LEU A . n 
A 1 171 LEU 171 171 171 LEU LEU A . n 
A 1 172 GLY 172 172 172 GLY GLY A . n 
A 1 173 GLY 173 173 173 GLY GLY A . n 
A 1 174 PRO 174 174 174 PRO PRO A . n 
A 1 175 GLY 175 175 175 GLY GLY A . n 
A 1 176 SER 176 176 176 SER SER A . n 
A 1 177 PHE 177 177 177 PHE PHE A . n 
A 1 178 TYR 178 178 178 TYR TYR A . n 
A 1 179 TRP 179 179 179 TRP TRP A . n 
A 1 180 GLN 180 180 180 GLN GLN A . n 
A 1 181 GLY 181 181 181 GLY GLY A . n 
A 1 182 GLN 182 182 182 GLN GLN A . n 
A 1 183 LEU 183 183 183 LEU LEU A . n 
A 1 184 ILE 184 184 184 ILE ILE A . n 
A 1 185 SER 185 185 185 SER SER A . n 
A 1 186 ASP 186 186 186 ASP ASP A . n 
A 1 187 GLN 187 187 187 GLN GLN A . n 
A 1 188 VAL 188 188 188 VAL VAL A . n 
A 1 189 ALA 189 189 189 ALA ALA A . n 
A 1 190 GLU 190 190 190 GLU GLU A . n 
A 1 191 ILE 191 191 191 ILE ILE A . n 
A 1 192 VAL 192 192 192 VAL VAL A . n 
A 1 193 SER 193 193 193 SER SER A . n 
A 1 194 LYS 194 194 194 LYS LYS A . n 
A 1 195 TYR 195 195 195 TYR TYR A . n 
A 1 196 ASP 196 196 196 ASP ASP A . n 
A 1 197 PRO 197 197 197 PRO PRO A . n 
A 1 198 ASN 198 198 198 ASN ASN A . n 
A 1 199 VAL 199 199 199 VAL VAL A . n 
A 1 200 TYR 200 200 200 TYR TYR A . n 
A 1 201 SER 201 201 201 SER SER A . n 
A 1 202 ILE 202 202 202 ILE ILE A . n 
A 1 203 LYS 203 203 203 LYS LYS A . n 
A 1 204 TYR 204 204 204 TYR TYR A . n 
A 1 205 ASN 205 205 205 ASN ASN A . n 
A 1 206 ASN 206 206 206 ASN ASN A . n 
A 1 207 GLN 207 207 207 GLN GLN A . n 
A 1 208 LEU 208 208 208 LEU LEU A . n 
A 1 209 ALA 209 209 209 ALA ALA A . n 
A 1 210 THR 210 210 210 THR THR A . n 
A 1 211 ARG 211 211 211 ARG ARG A . n 
A 1 212 THR 212 212 212 THR THR A . n 
A 1 213 ALA 213 213 213 ALA ALA A . n 
A 1 214 GLN 214 214 214 GLN GLN A . n 
A 1 215 ALA 215 215 215 ALA ALA A . n 
A 1 216 ILE 216 216 216 ILE ILE A . n 
A 1 217 PHE 217 217 217 PHE PHE A . n 
A 1 218 ASP 218 218 218 ASP ASP A . n 
A 1 219 ASP 219 219 219 ASP ASP A . n 
A 1 220 SER 220 220 220 SER SER A . n 
A 1 221 TYR 221 221 221 TYR TYR A . n 
A 1 222 LEU 222 222 222 LEU LEU A . n 
A 1 223 GLY 223 223 223 GLY GLY A . n 
A 1 224 TYR 224 224 224 TYR TYR A . n 
A 1 225 SER 225 225 225 SER SER A . n 
A 1 226 VAL 226 226 226 VAL VAL A . n 
A 1 227 ALA 227 227 227 ALA ALA A . n 
A 1 228 VAL 228 228 228 VAL VAL A . n 
A 1 229 GLY 229 229 229 GLY GLY A . n 
A 1 230 ASP 230 230 230 ASP ASP A . n 
A 1 231 PHE 231 231 231 PHE PHE A . n 
A 1 232 ASN 232 232 232 ASN ASN A . n 
A 1 233 GLY 233 233 233 GLY GLY A . n 
A 1 234 ASP 234 234 234 ASP ASP A . n 
A 1 235 GLY 235 235 235 GLY GLY A . n 
A 1 236 ILE 236 236 236 ILE ILE A . n 
A 1 237 ASP 237 237 237 ASP ASP A . n 
A 1 238 ASP 238 238 238 ASP ASP A . n 
A 1 239 PHE 239 239 239 PHE PHE A . n 
A 1 240 VAL 240 240 240 VAL VAL A . n 
A 1 241 SER 241 241 241 SER SER A . n 
A 1 242 GLY 242 242 242 GLY GLY A . n 
A 1 243 VAL 243 243 243 VAL VAL A . n 
A 1 244 PRO 244 244 244 PRO PRO A . n 
A 1 245 ARG 245 245 245 ARG ARG A . n 
A 1 246 ALA 246 246 246 ALA ALA A . n 
A 1 247 ALA 247 247 247 ALA ALA A . n 
A 1 248 ARG 248 248 248 ARG ARG A . n 
A 1 249 THR 249 249 249 THR THR A . n 
A 1 250 LEU 250 250 250 LEU LEU A . n 
A 1 251 GLY 251 251 251 GLY GLY A . n 
A 1 252 MET 252 252 252 MET MET A . n 
A 1 253 VAL 253 253 253 VAL VAL A . n 
A 1 254 TYR 254 254 254 TYR TYR A . n 
A 1 255 ILE 255 255 255 ILE ILE A . n 
A 1 256 TYR 256 256 256 TYR TYR A . n 
A 1 257 ASP 257 257 257 ASP ASP A . n 
A 1 258 GLY 258 258 258 GLY GLY A . n 
A 1 259 LYS 259 259 259 LYS LYS A . n 
A 1 260 ASN 260 260 260 ASN ASN A . n 
A 1 261 MET 261 261 261 MET MET A . n 
A 1 262 SER 262 262 262 SER SER A . n 
A 1 263 SER 263 263 263 SER SER A . n 
A 1 264 LEU 264 264 264 LEU LEU A . n 
A 1 265 TYR 265 265 265 TYR TYR A . n 
A 1 266 ASN 266 266 266 ASN ASN A . n 
A 1 267 PHE 267 267 267 PHE PHE A . n 
A 1 268 THR 268 268 268 THR THR A . n 
A 1 269 GLY 269 269 269 GLY GLY A . n 
A 1 270 GLU 270 270 270 GLU GLU A . n 
A 1 271 GLN 271 271 271 GLN GLN A . n 
A 1 272 MET 272 272 272 MET MET A . n 
A 1 273 ALA 273 273 273 ALA ALA A . n 
A 1 274 ALA 274 274 274 ALA ALA A . n 
A 1 275 TYR 275 275 275 TYR TYR A . n 
A 1 276 PHE 276 276 276 PHE PHE A . n 
A 1 277 GLY 277 277 277 GLY GLY A . n 
A 1 278 PHE 278 278 278 PHE PHE A . n 
A 1 279 SER 279 279 279 SER SER A . n 
A 1 280 VAL 280 280 280 VAL VAL A . n 
A 1 281 ALA 281 281 281 ALA ALA A . n 
A 1 282 ALA 282 282 282 ALA ALA A . n 
A 1 283 THR 283 283 283 THR THR A . n 
A 1 284 ASP 284 284 284 ASP ASP A . n 
A 1 285 ILE 285 285 285 ILE ILE A . n 
A 1 286 ASN 286 286 286 ASN ASN A . n 
A 1 287 GLY 287 287 287 GLY GLY A . n 
A 1 288 ASP 288 288 288 ASP ASP A . n 
A 1 289 ASP 289 289 289 ASP ASP A . n 
A 1 290 TYR 290 290 290 TYR TYR A . n 
A 1 291 ALA 291 291 291 ALA ALA A . n 
A 1 292 ASP 292 292 292 ASP ASP A . n 
A 1 293 VAL 293 293 293 VAL VAL A . n 
A 1 294 PHE 294 294 294 PHE PHE A . n 
A 1 295 ILE 295 295 295 ILE ILE A . n 
A 1 296 GLY 296 296 296 GLY GLY A . n 
A 1 297 ALA 297 297 297 ALA ALA A . n 
A 1 298 PRO 298 298 298 PRO PRO A . n 
A 1 299 LEU 299 299 299 LEU LEU A . n 
A 1 300 PHE 300 300 300 PHE PHE A . n 
A 1 301 MET 301 301 301 MET MET A . n 
A 1 302 ASP 302 302 302 ASP ASP A . n 
A 1 303 ARG 303 303 303 ARG ARG A . n 
A 1 304 GLY 304 304 304 GLY GLY A . n 
A 1 305 SER 305 305 305 SER SER A . n 
A 1 306 ASP 306 306 306 ASP ASP A . n 
A 1 307 GLY 307 307 307 GLY GLY A . n 
A 1 308 LYS 308 308 308 LYS LYS A . n 
A 1 309 LEU 309 309 309 LEU LEU A . n 
A 1 310 GLN 310 310 310 GLN GLN A . n 
A 1 311 GLU 311 311 311 GLU GLU A . n 
A 1 312 VAL 312 312 312 VAL VAL A . n 
A 1 313 GLY 313 313 313 GLY GLY A . n 
A 1 314 GLN 314 314 314 GLN GLN A . n 
A 1 315 VAL 315 315 315 VAL VAL A . n 
A 1 316 SER 316 316 316 SER SER A . n 
A 1 317 VAL 317 317 317 VAL VAL A . n 
A 1 318 SER 318 318 318 SER SER A . n 
A 1 319 LEU 319 319 319 LEU LEU A . n 
A 1 320 GLN 320 320 320 GLN GLN A . n 
A 1 321 ARG 321 321 321 ARG ARG A . n 
A 1 322 ALA 322 322 322 ALA ALA A . n 
A 1 323 SER 323 323 323 SER SER A . n 
A 1 324 GLY 324 324 324 GLY GLY A . n 
A 1 325 ASP 325 325 325 ASP ASP A . n 
A 1 326 PHE 326 326 326 PHE PHE A . n 
A 1 327 GLN 327 327 327 GLN GLN A . n 
A 1 328 THR 328 328 328 THR THR A . n 
A 1 329 THR 329 329 329 THR THR A . n 
A 1 330 LYS 330 330 330 LYS LYS A . n 
A 1 331 LEU 331 331 331 LEU LEU A . n 
A 1 332 ASN 332 332 332 ASN ASN A . n 
A 1 333 GLY 333 333 333 GLY GLY A . n 
A 1 334 PHE 334 334 334 PHE PHE A . n 
A 1 335 GLU 335 335 335 GLU GLU A . n 
A 1 336 VAL 336 336 336 VAL VAL A . n 
A 1 337 PHE 337 337 337 PHE PHE A . n 
A 1 338 ALA 338 338 338 ALA ALA A . n 
A 1 339 ARG 339 339 339 ARG ARG A . n 
A 1 340 PHE 340 340 340 PHE PHE A . n 
A 1 341 GLY 341 341 341 GLY GLY A . n 
A 1 342 SER 342 342 342 SER SER A . n 
A 1 343 ALA 343 343 343 ALA ALA A . n 
A 1 344 ILE 344 344 344 ILE ILE A . n 
A 1 345 ALA 345 345 345 ALA ALA A . n 
A 1 346 PRO 346 346 346 PRO PRO A . n 
A 1 347 LEU 347 347 347 LEU LEU A . n 
A 1 348 GLY 348 348 348 GLY GLY A . n 
A 1 349 ASP 349 349 349 ASP ASP A . n 
A 1 350 LEU 350 350 350 LEU LEU A . n 
A 1 351 ASP 351 351 351 ASP ASP A . n 
A 1 352 GLN 352 352 352 GLN GLN A . n 
A 1 353 ASP 353 353 353 ASP ASP A . n 
A 1 354 GLY 354 354 354 GLY GLY A . n 
A 1 355 PHE 355 355 355 PHE PHE A . n 
A 1 356 ASN 356 356 356 ASN ASN A . n 
A 1 357 ASP 357 357 357 ASP ASP A . n 
A 1 358 ILE 358 358 358 ILE ILE A . n 
A 1 359 ALA 359 359 359 ALA ALA A . n 
A 1 360 ILE 360 360 360 ILE ILE A . n 
A 1 361 ALA 361 361 361 ALA ALA A . n 
A 1 362 ALA 362 362 362 ALA ALA A . n 
A 1 363 PRO 363 363 363 PRO PRO A . n 
A 1 364 TYR 364 364 364 TYR TYR A . n 
A 1 365 GLY 365 365 365 GLY GLY A . n 
A 1 366 GLY 366 366 366 GLY GLY A . n 
A 1 367 GLU 367 367 367 GLU GLU A . n 
A 1 368 ASP 368 368 368 ASP ASP A . n 
A 1 369 LYS 369 369 369 LYS LYS A . n 
A 1 370 LYS 370 370 370 LYS LYS A . n 
A 1 371 GLY 371 371 371 GLY GLY A . n 
A 1 372 ILE 372 372 372 ILE ILE A . n 
A 1 373 VAL 373 373 373 VAL VAL A . n 
A 1 374 TYR 374 374 374 TYR TYR A . n 
A 1 375 ILE 375 375 375 ILE ILE A . n 
A 1 376 PHE 376 376 376 PHE PHE A . n 
A 1 377 ASN 377 377 377 ASN ASN A . n 
A 1 378 GLY 378 378 378 GLY GLY A . n 
A 1 379 ARG 379 379 379 ARG ARG A . n 
A 1 380 SER 380 380 380 SER SER A . n 
A 1 381 THR 381 381 381 THR THR A . n 
A 1 382 GLY 382 382 382 GLY GLY A . n 
A 1 383 LEU 383 383 383 LEU LEU A . n 
A 1 384 ASN 384 384 384 ASN ASN A . n 
A 1 385 ALA 385 385 385 ALA ALA A . n 
A 1 386 VAL 386 386 386 VAL VAL A . n 
A 1 387 PRO 387 387 387 PRO PRO A . n 
A 1 388 SER 388 388 388 SER SER A . n 
A 1 389 GLN 389 389 389 GLN GLN A . n 
A 1 390 ILE 390 390 390 ILE ILE A . n 
A 1 391 LEU 391 391 391 LEU LEU A . n 
A 1 392 GLU 392 392 392 GLU GLU A . n 
A 1 393 GLY 393 393 393 GLY GLY A . n 
A 1 394 GLN 394 394 394 GLN GLN A . n 
A 1 395 TRP 395 395 395 TRP TRP A . n 
A 1 396 ALA 396 396 396 ALA ALA A . n 
A 1 397 ALA 397 397 397 ALA ALA A . n 
A 1 398 ARG 398 398 398 ARG ARG A . n 
A 1 399 SER 399 399 399 SER SER A . n 
A 1 400 MET 400 400 400 MET MET A . n 
A 1 401 PRO 401 401 401 PRO PRO A . n 
A 1 402 PRO 402 402 402 PRO PRO A . n 
A 1 403 SER 403 403 403 SER SER A . n 
A 1 404 PHE 404 404 404 PHE PHE A . n 
A 1 405 GLY 405 405 405 GLY GLY A . n 
A 1 406 TYR 406 406 406 TYR TYR A . n 
A 1 407 SER 407 407 407 SER SER A . n 
A 1 408 MET 408 408 408 MET MET A . n 
A 1 409 LYS 409 409 409 LYS LYS A . n 
A 1 410 GLY 410 410 410 GLY GLY A . n 
A 1 411 ALA 411 411 411 ALA ALA A . n 
A 1 412 THR 412 412 412 THR THR A . n 
A 1 413 ASP 413 413 413 ASP ASP A . n 
A 1 414 ILE 414 414 414 ILE ILE A . n 
A 1 415 ASP 415 415 415 ASP ASP A . n 
A 1 416 LYS 416 416 416 LYS LYS A . n 
A 1 417 ASN 417 417 417 ASN ASN A . n 
A 1 418 GLY 418 418 418 GLY GLY A . n 
A 1 419 TRP 419 419 419 TRP TRP A . n 
A 1 420 PRO 420 420 420 PRO PRO A . n 
A 1 421 ASP 421 421 421 ASP ASP A . n 
A 1 422 LEU 422 422 422 LEU LEU A . n 
A 1 423 ILE 423 423 423 ILE ILE A . n 
A 1 424 VAL 424 424 424 VAL VAL A . n 
A 1 425 GLY 425 425 425 GLY GLY A . n 
A 1 426 ALA 426 426 426 ALA ALA A . n 
A 1 427 PHE 427 427 427 PHE PHE A . n 
A 1 428 GLY 428 428 428 GLY GLY A . n 
A 1 429 VAL 429 429 429 VAL VAL A . n 
A 1 430 ASP 430 430 430 ASP ASP A . n 
A 1 431 ARG 431 431 431 ARG ARG A . n 
A 1 432 ALA 432 432 432 ALA ALA A . n 
A 1 433 ILE 433 433 433 ILE ILE A . n 
A 1 434 LEU 434 434 434 LEU LEU A . n 
A 1 435 TYR 435 435 435 TYR TYR A . n 
A 1 436 ARG 436 436 436 ARG ARG A . n 
A 1 437 ALA 437 437 437 ALA ALA A . n 
A 1 438 ARG 438 438 438 ARG ARG A . n 
A 1 439 PRO 439 439 439 PRO PRO A . n 
A 1 440 VAL 440 440 440 VAL VAL A . n 
B 2 1   GLU 1   1   1   GLU GLU H . n 
B 2 2   VAL 2   2   2   VAL VAL H . n 
B 2 3   GLN 3   3   3   GLN GLN H . n 
B 2 4   LEU 4   4   4   LEU LEU H . n 
B 2 5   VAL 5   5   5   VAL VAL H . n 
B 2 6   GLN 6   6   6   GLN GLN H . n 
B 2 7   SER 7   7   7   SER SER H . n 
B 2 8   GLY 8   8   8   GLY GLY H . n 
B 2 9   ALA 9   9   9   ALA ALA H . n 
B 2 10  GLU 10  10  10  GLU GLU H . n 
B 2 11  VAL 11  11  11  VAL VAL H . n 
B 2 12  LYS 12  12  12  LYS LYS H . n 
B 2 13  LYS 13  13  13  LYS LYS H . n 
B 2 14  PRO 14  14  14  PRO PRO H . n 
B 2 15  GLY 15  15  15  GLY GLY H . n 
B 2 16  ALA 16  16  16  ALA ALA H . n 
B 2 17  SER 17  17  17  SER SER H . n 
B 2 18  VAL 18  18  18  VAL VAL H . n 
B 2 19  LYS 19  19  19  LYS LYS H . n 
B 2 20  VAL 20  20  20  VAL VAL H . n 
B 2 21  SER 21  21  21  SER SER H . n 
B 2 22  CYS 22  22  22  CYS CYS H . n 
B 2 23  LYS 23  23  23  LYS LYS H . n 
B 2 24  ALA 24  24  24  ALA ALA H . n 
B 2 25  SER 25  25  25  SER SER H . n 
B 2 26  GLY 26  26  26  GLY GLY H . n 
B 2 27  TYR 27  27  27  TYR TYR H . n 
B 2 28  THR 28  28  28  THR THR H . n 
B 2 29  PHE 29  29  29  PHE PHE H . n 
B 2 30  THR 30  30  30  THR THR H . n 
B 2 31  ASN 31  31  31  ASN ASN H . n 
B 2 32  TYR 32  32  32  TYR TYR H . n 
B 2 33  GLY 33  33  33  GLY GLY H . n 
B 2 34  ILE 34  34  34  ILE ILE H . n 
B 2 35  ASN 35  35  35  ASN ASN H . n 
B 2 36  TRP 36  36  36  TRP TRP H . n 
B 2 37  VAL 37  37  37  VAL VAL H . n 
B 2 38  ARG 38  38  38  ARG ARG H . n 
B 2 39  GLN 39  39  39  GLN GLN H . n 
B 2 40  ALA 40  40  40  ALA ALA H . n 
B 2 41  PRO 41  41  41  PRO PRO H . n 
B 2 42  GLY 42  42  42  GLY GLY H . n 
B 2 43  GLN 43  43  43  GLN GLN H . n 
B 2 44  GLY 44  44  44  GLY GLY H . n 
B 2 45  LEU 45  45  45  LEU LEU H . n 
B 2 46  GLU 46  46  46  GLU GLU H . n 
B 2 47  TRP 47  47  47  TRP TRP H . n 
B 2 48  MET 48  48  48  MET MET H . n 
B 2 49  GLY 49  49  49  GLY GLY H . n 
B 2 50  TYR 50  50  50  TYR TYR H . n 
B 2 51  PHE 51  51  51  PHE PHE H . n 
B 2 52  TYR 52  52  52  TYR TYR H . n 
B 2 53  ILE 53  53  53  ILE ILE H . n 
B 2 54  GLY 54  54  54  GLY GLY H . n 
B 2 55  ASN 55  55  55  ASN ASN H . n 
B 2 56  GLY 56  56  56  GLY GLY H . n 
B 2 57  TYR 57  57  57  TYR TYR H . n 
B 2 58  THR 58  58  58  THR THR H . n 
B 2 59  GLU 59  59  59  GLU GLU H . n 
B 2 60  TYR 60  60  60  TYR TYR H . n 
B 2 61  ASN 61  61  61  ASN ASN H . n 
B 2 62  GLU 62  62  62  GLU GLU H . n 
B 2 63  LYS 63  63  63  LYS LYS H . n 
B 2 64  PHE 64  64  64  PHE PHE H . n 
B 2 65  LYS 65  65  65  LYS LYS H . n 
B 2 66  GLY 66  66  66  GLY GLY H . n 
B 2 67  ARG 67  67  67  ARG ARG H . n 
B 2 68  VAL 68  68  68  VAL VAL H . n 
B 2 69  THR 69  69  69  THR THR H . n 
B 2 70  MET 70  70  70  MET MET H . n 
B 2 71  THR 71  71  71  THR THR H . n 
B 2 72  SER 72  72  72  SER SER H . n 
B 2 73  ASP 73  73  73  ASP ASP H . n 
B 2 74  THR 74  74  74  THR THR H . n 
B 2 75  SER 75  75  75  SER SER H . n 
B 2 76  THR 76  76  76  THR THR H . n 
B 2 77  SER 77  77  77  SER SER H . n 
B 2 78  THR 78  78  78  THR THR H . n 
B 2 79  VAL 79  79  79  VAL VAL H . n 
B 2 80  TYR 80  80  80  TYR TYR H . n 
B 2 81  MET 81  81  81  MET MET H . n 
B 2 82  GLU 82  82  82  GLU GLU H . n 
B 2 83  LEU 83  83  83  LEU LEU H . n 
B 2 84  SER 84  84  84  SER SER H . n 
B 2 85  SER 85  85  85  SER SER H . n 
B 2 86  LEU 86  86  86  LEU LEU H . n 
B 2 87  ARG 87  87  87  ARG ARG H . n 
B 2 88  SER 88  88  88  SER SER H . n 
B 2 89  GLU 89  89  89  GLU GLU H . n 
B 2 90  ASP 90  90  90  ASP ASP H . n 
B 2 91  THR 91  91  91  THR THR H . n 
B 2 92  ALA 92  92  92  ALA ALA H . n 
B 2 93  VAL 93  93  93  VAL VAL H . n 
B 2 94  TYR 94  94  94  TYR TYR H . n 
B 2 95  TYR 95  95  95  TYR TYR H . n 
B 2 96  CYS 96  96  96  CYS CYS H . n 
B 2 97  ALA 97  97  97  ALA ALA H . n 
B 2 98  LEU 98  98  98  LEU LEU H . n 
B 2 99  ASN 99  99  99  ASN ASN H . n 
B 2 100 TYR 100 100 100 TYR TYR H . n 
B 2 101 PHE 101 101 101 PHE PHE H . n 
B 2 102 GLY 102 102 102 GLY GLY H . n 
B 2 103 SER 103 103 103 SER SER H . n 
B 2 104 ARG 104 104 104 ARG ARG H . n 
B 2 105 LYS 105 105 105 LYS LYS H . n 
B 2 106 PHE 106 106 106 PHE PHE H . n 
B 2 107 ASP 107 107 107 ASP ASP H . n 
B 2 108 TYR 108 108 108 TYR TYR H . n 
B 2 109 TRP 109 109 109 TRP TRP H . n 
B 2 110 GLY 110 110 110 GLY GLY H . n 
B 2 111 GLN 111 111 111 GLN GLN H . n 
B 2 112 GLY 112 112 112 GLY GLY H . n 
B 2 113 THR 113 113 113 THR THR H . n 
B 2 114 THR 114 114 114 THR THR H . n 
B 2 115 VAL 115 115 115 VAL VAL H . n 
B 2 116 THR 116 116 116 THR THR H . n 
B 2 117 VAL 117 117 117 VAL VAL H . n 
B 2 118 SER 118 118 118 SER SER H . n 
B 2 119 SER 119 119 119 SER SER H . n 
C 3 1   GLU 1   1   1   GLU GLU L . n 
C 3 2   ILE 2   2   2   ILE ILE L . n 
C 3 3   VAL 3   3   3   VAL VAL L . n 
C 3 4   LEU 4   4   4   LEU LEU L . n 
C 3 5   THR 5   5   5   THR THR L . n 
C 3 6   GLN 6   6   6   GLN GLN L . n 
C 3 7   SER 7   7   7   SER SER L . n 
C 3 8   PRO 8   8   8   PRO PRO L . n 
C 3 9   ALA 9   9   9   ALA ALA L . n 
C 3 10  THR 10  10  10  THR THR L . n 
C 3 11  LEU 11  11  11  LEU LEU L . n 
C 3 12  SER 12  12  12  SER SER L . n 
C 3 13  LEU 13  13  13  LEU LEU L . n 
C 3 14  SER 14  14  14  SER SER L . n 
C 3 15  PRO 15  15  15  PRO PRO L . n 
C 3 16  GLY 16  16  16  GLY GLY L . n 
C 3 17  GLU 17  17  17  GLU GLU L . n 
C 3 18  ARG 18  18  18  ARG ARG L . n 
C 3 19  ALA 19  19  19  ALA ALA L . n 
C 3 20  THR 20  20  20  THR THR L . n 
C 3 21  LEU 21  21  21  LEU LEU L . n 
C 3 22  SER 22  22  22  SER SER L . n 
C 3 23  CYS 23  23  23  CYS CYS L . n 
C 3 24  ARG 24  24  24  ARG ARG L . n 
C 3 25  ALA 25  25  25  ALA ALA L . n 
C 3 26  SER 26  26  26  SER SER L . n 
C 3 27  GLN 27  27  27  GLN GLN L . n 
C 3 28  ASN 28  28  28  ASN ASN L . n 
C 3 29  ILE 29  29  29  ILE ILE L . n 
C 3 30  ILE 30  30  30  ILE ILE L . n 
C 3 31  THR 31  31  31  THR THR L . n 
C 3 32  ASN 32  32  32  ASN ASN L . n 
C 3 33  LEU 33  33  33  LEU LEU L . n 
C 3 34  HIS 34  34  34  HIS HIS L . n 
C 3 35  TRP 35  35  35  TRP TRP L . n 
C 3 36  TYR 36  36  36  TYR TYR L . n 
C 3 37  GLN 37  37  37  GLN GLN L . n 
C 3 38  GLN 38  38  38  GLN GLN L . n 
C 3 39  LYS 39  39  39  LYS LYS L . n 
C 3 40  PRO 40  40  40  PRO PRO L . n 
C 3 41  GLY 41  41  41  GLY GLY L . n 
C 3 42  GLN 42  42  42  GLN GLN L . n 
C 3 43  ALA 43  43  43  ALA ALA L . n 
C 3 44  PRO 44  44  44  PRO PRO L . n 
C 3 45  ARG 45  45  45  ARG ARG L . n 
C 3 46  LEU 46  46  46  LEU LEU L . n 
C 3 47  LEU 47  47  47  LEU LEU L . n 
C 3 48  ILE 48  48  48  ILE ILE L . n 
C 3 49  LYS 49  49  49  LYS LYS L . n 
C 3 50  TYR 50  50  50  TYR TYR L . n 
C 3 51  ALA 51  51  51  ALA ALA L . n 
C 3 52  SER 52  52  52  SER SER L . n 
C 3 53  GLN 53  53  53  GLN GLN L . n 
C 3 54  SER 54  54  54  SER SER L . n 
C 3 55  ILE 55  55  55  ILE ILE L . n 
C 3 56  SER 56  56  56  SER SER L . n 
C 3 57  GLY 57  57  57  GLY GLY L . n 
C 3 58  ILE 58  58  58  ILE ILE L . n 
C 3 59  PRO 59  59  59  PRO PRO L . n 
C 3 60  ALA 60  60  60  ALA ALA L . n 
C 3 61  ARG 61  61  61  ARG ARG L . n 
C 3 62  PHE 62  62  62  PHE PHE L . n 
C 3 63  SER 63  63  63  SER SER L . n 
C 3 64  GLY 64  64  64  GLY GLY L . n 
C 3 65  SER 65  65  65  SER SER L . n 
C 3 66  GLY 66  66  66  GLY GLY L . n 
C 3 67  SER 67  67  67  SER SER L . n 
C 3 68  GLY 68  68  68  GLY GLY L . n 
C 3 69  THR 69  69  69  THR THR L . n 
C 3 70  ASP 70  70  70  ASP ASP L . n 
C 3 71  PHE 71  71  71  PHE PHE L . n 
C 3 72  THR 72  72  72  THR THR L . n 
C 3 73  LEU 73  73  73  LEU LEU L . n 
C 3 74  THR 74  74  74  THR THR L . n 
C 3 75  ILE 75  75  75  ILE ILE L . n 
C 3 76  SER 76  76  76  SER SER L . n 
C 3 77  SER 77  77  77  SER SER L . n 
C 3 78  LEU 78  78  78  LEU LEU L . n 
C 3 79  GLU 79  79  79  GLU GLU L . n 
C 3 80  PRO 80  80  80  PRO PRO L . n 
C 3 81  GLU 81  81  81  GLU GLU L . n 
C 3 82  ASP 82  82  82  ASP ASP L . n 
C 3 83  PHE 83  83  83  PHE PHE L . n 
C 3 84  ALA 84  84  84  ALA ALA L . n 
C 3 85  VAL 85  85  85  VAL VAL L . n 
C 3 86  TYR 86  86  86  TYR TYR L . n 
C 3 87  PHE 87  87  87  PHE PHE L . n 
C 3 88  CYS 88  88  88  CYS CYS L . n 
C 3 89  GLN 89  89  89  GLN GLN L . n 
C 3 90  GLN 90  90  90  GLN GLN L . n 
C 3 91  SER 91  91  91  SER SER L . n 
C 3 92  ASP 92  92  92  ASP ASP L . n 
C 3 93  ASP 93  93  93  ASP ASP L . n 
C 3 94  TRP 94  94  94  TRP TRP L . n 
C 3 95  PRO 95  95  95  PRO PRO L . n 
C 3 96  LEU 96  96  96  LEU LEU L . n 
C 3 97  THR 97  97  97  THR THR L . n 
C 3 98  PHE 98  98  98  PHE PHE L . n 
C 3 99  GLY 99  99  99  GLY GLY L . n 
C 3 100 GLN 100 100 100 GLN GLN L . n 
C 3 101 GLY 101 101 101 GLY GLY L . n 
C 3 102 THR 102 102 102 THR THR L . n 
C 3 103 LYS 103 103 103 LYS LYS L . n 
C 3 104 LEU 104 104 104 LEU LEU L . n 
D 4 1   ASN 1   70  70  ASN ASN B . n 
D 4 2   GLU 2   71  71  GLU GLU B . n 
D 4 3   ILE 3   72  72  ILE ILE B . n 
D 4 4   ASN 4   73  73  ASN ASN B . n 
D 4 5   THR 5   74  74  THR THR B . n 
D 4 6   GLN 6   75  75  GLN GLN B . n 
D 4 7   VAL 7   76  76  VAL VAL B . n 
D 4 8   THR 8   77  77  THR THR B . n 
D 4 9   PRO 9   78  78  PRO PRO B . n 
D 4 10  GLY 10  79  79  GLY GLY B . n 
D 4 11  GLU 11  80  80  GLU GLU B . n 
D 4 12  VAL 12  81  81  VAL VAL B . n 
D 4 13  SER 13  82  82  SER SER B . n 
D 4 14  ILE 14  83  83  ILE ILE B . n 
D 4 15  GLN 15  84  84  GLN GLN B . n 
D 4 16  LEU 16  85  85  LEU LEU B . n 
D 4 17  ARG 17  86  86  ARG ARG B . n 
D 4 18  PRO 18  87  87  PRO PRO B . n 
D 4 19  GLY 19  88  88  GLY GLY B . n 
D 4 20  ALA 20  89  89  ALA ALA B . n 
D 4 21  GLU 21  90  90  GLU GLU B . n 
D 4 22  ALA 22  91  91  ALA ALA B . n 
D 4 23  ASN 23  92  92  ASN ASN B . n 
D 4 24  PHE 24  93  93  PHE PHE B . n 
D 4 25  MET 25  94  94  MET MET B . n 
D 4 26  LEU 26  95  95  LEU LEU B . n 
D 4 27  LYS 27  96  96  LYS LYS B . n 
D 4 28  VAL 28  97  97  VAL VAL B . n 
D 4 29  HIS 29  98  98  HIS HIS B . n 
D 4 30  PRO 30  99  99  PRO PRO B . n 
D 4 31  LEU 31  100 100 LEU LEU B . n 
D 4 32  LYS 32  101 101 LYS LYS B . n 
D 4 33  LYS 33  102 102 LYS LYS B . n 
D 4 34  TYR 34  103 103 TYR TYR B . n 
D 4 35  PRO 35  104 104 PRO PRO B . n 
D 4 36  VAL 36  105 105 VAL VAL B . n 
D 4 37  ASP 37  106 106 ASP ASP B . n 
D 4 38  LEU 38  107 107 LEU LEU B . n 
D 4 39  TYR 39  108 108 TYR TYR B . n 
D 4 40  TYR 40  109 109 TYR TYR B . n 
D 4 41  LEU 41  110 110 LEU LEU B . n 
D 4 42  VAL 42  111 111 VAL VAL B . n 
D 4 43  ASP 43  112 112 ASP ASP B . n 
D 4 44  VAL 44  113 113 VAL VAL B . n 
D 4 45  SER 45  114 114 SER SER B . n 
D 4 46  ALA 46  115 115 ALA ALA B . n 
D 4 47  SER 47  116 116 SER SER B . n 
D 4 48  MET 48  117 117 MET MET B . n 
D 4 49  HIS 49  118 118 HIS HIS B . n 
D 4 50  ASN 50  119 119 ASN ASN B . n 
D 4 51  ASN 51  120 120 ASN ASN B . n 
D 4 52  ILE 52  121 121 ILE ILE B . n 
D 4 53  GLU 53  122 122 GLU GLU B . n 
D 4 54  LYS 54  123 123 LYS LYS B . n 
D 4 55  LEU 55  124 124 LEU LEU B . n 
D 4 56  ASN 56  125 125 ASN ASN B . n 
D 4 57  SER 57  126 126 SER SER B . n 
D 4 58  VAL 58  127 127 VAL VAL B . n 
D 4 59  GLY 59  128 128 GLY GLY B . n 
D 4 60  ASN 60  129 129 ASN ASN B . n 
D 4 61  ASP 61  130 130 ASP ASP B . n 
D 4 62  LEU 62  131 131 LEU LEU B . n 
D 4 63  SER 63  132 132 SER SER B . n 
D 4 64  ARG 64  133 133 ARG ARG B . n 
D 4 65  LYS 65  134 134 LYS LYS B . n 
D 4 66  MET 66  135 135 MET MET B . n 
D 4 67  ALA 67  136 136 ALA ALA B . n 
D 4 68  PHE 68  137 137 PHE PHE B . n 
D 4 69  PHE 69  138 138 PHE PHE B . n 
D 4 70  SER 70  139 139 SER SER B . n 
D 4 71  ARG 71  140 140 ARG ARG B . n 
D 4 72  ASP 72  141 141 ASP ASP B . n 
D 4 73  PHE 73  142 142 PHE PHE B . n 
D 4 74  ARG 74  143 143 ARG ARG B . n 
D 4 75  LEU 75  144 144 LEU LEU B . n 
D 4 76  GLY 76  145 145 GLY GLY B . n 
D 4 77  PHE 77  146 146 PHE PHE B . n 
D 4 78  GLY 78  147 147 GLY GLY B . n 
D 4 79  SER 79  148 148 SER SER B . n 
D 4 80  TYR 80  149 149 TYR TYR B . n 
D 4 81  VAL 81  150 150 VAL VAL B . n 
D 4 82  ASP 82  151 151 ASP ASP B . n 
D 4 83  LYS 83  152 152 LYS LYS B . n 
D 4 84  THR 84  153 153 THR THR B . n 
D 4 85  VAL 85  154 154 VAL VAL B . n 
D 4 86  SER 86  155 155 SER SER B . n 
D 4 87  PRO 87  156 156 PRO PRO B . n 
D 4 88  TYR 88  157 157 TYR TYR B . n 
D 4 89  ILE 89  158 158 ILE ILE B . n 
D 4 90  SER 90  159 159 SER SER B . n 
D 4 91  ILE 91  160 160 ILE ILE B . n 
D 4 92  HIS 92  161 161 HIS HIS B . n 
D 4 93  PRO 93  162 162 PRO PRO B . n 
D 4 94  GLU 94  163 163 GLU GLU B . n 
D 4 95  ARG 95  164 164 ARG ARG B . n 
D 4 96  ILE 96  165 165 ILE ILE B . n 
D 4 97  HIS 97  166 166 HIS HIS B . n 
D 4 98  ASN 98  167 167 ASN ASN B . n 
D 4 99  GLN 99  168 168 GLN GLN B . n 
D 4 100 CYS 100 169 169 CYS CYS B . n 
D 4 101 SER 101 170 170 SER SER B . n 
D 4 102 ASP 102 171 171 ASP ASP B . n 
D 4 103 TYR 103 172 172 TYR TYR B . n 
D 4 104 ASN 104 173 173 ASN ASN B . n 
D 4 105 LEU 105 174 174 LEU LEU B . n 
D 4 106 ASP 106 175 175 ASP ASP B . n 
D 4 107 CYS 107 176 176 CYS CYS B . n 
D 4 108 MET 108 177 177 MET MET B . n 
D 4 109 PRO 109 178 178 PRO PRO B . n 
D 4 110 PRO 110 179 179 PRO PRO B . n 
D 4 111 HIS 111 180 180 HIS HIS B . n 
D 4 112 GLY 112 181 181 GLY GLY B . n 
D 4 113 TYR 113 182 182 TYR TYR B . n 
D 4 114 ILE 114 183 183 ILE ILE B . n 
D 4 115 HIS 115 184 184 HIS HIS B . n 
D 4 116 VAL 116 185 185 VAL VAL B . n 
D 4 117 LEU 117 186 186 LEU LEU B . n 
D 4 118 SER 118 187 187 SER SER B . n 
D 4 119 LEU 119 188 188 LEU LEU B . n 
D 4 120 THR 120 189 189 THR THR B . n 
D 4 121 GLU 121 190 190 GLU GLU B . n 
D 4 122 ASN 122 191 191 ASN ASN B . n 
D 4 123 ILE 123 192 192 ILE ILE B . n 
D 4 124 THR 124 193 193 THR THR B . n 
D 4 125 GLU 125 194 194 GLU GLU B . n 
D 4 126 PHE 126 195 195 PHE PHE B . n 
D 4 127 GLU 127 196 196 GLU GLU B . n 
D 4 128 LYS 128 197 197 LYS LYS B . n 
D 4 129 ALA 129 198 198 ALA ALA B . n 
D 4 130 VAL 130 199 199 VAL VAL B . n 
D 4 131 HIS 131 200 200 HIS HIS B . n 
D 4 132 ARG 132 201 201 ARG ARG B . n 
D 4 133 GLN 133 202 202 GLN GLN B . n 
D 4 134 LYS 134 203 203 LYS LYS B . n 
D 4 135 ILE 135 204 204 ILE ILE B . n 
D 4 136 SER 136 205 205 SER SER B . n 
D 4 137 GLY 137 206 206 GLY GLY B . n 
D 4 138 ASN 138 207 207 ASN ASN B . n 
D 4 139 ILE 139 208 208 ILE ILE B . n 
D 4 140 ASP 140 209 209 ASP ASP B . n 
D 4 141 THR 141 210 210 THR THR B . n 
D 4 142 PRO 142 211 211 PRO PRO B . n 
D 4 143 GLU 143 212 212 GLU GLU B . n 
D 4 144 GLY 144 213 213 GLY GLY B . n 
D 4 145 GLY 145 214 214 GLY GLY B . n 
D 4 146 PHE 146 215 215 PHE PHE B . n 
D 4 147 ASP 147 216 216 ASP ASP B . n 
D 4 148 ALA 148 217 217 ALA ALA B . n 
D 4 149 MET 149 218 218 MET MET B . n 
D 4 150 LEU 150 219 219 LEU LEU B . n 
D 4 151 GLN 151 220 220 GLN GLN B . n 
D 4 152 ALA 152 221 221 ALA ALA B . n 
D 4 153 ALA 153 222 222 ALA ALA B . n 
D 4 154 VAL 154 223 223 VAL VAL B . n 
D 4 155 CYS 155 224 224 CYS CYS B . n 
D 4 156 GLU 156 225 225 GLU GLU B . n 
D 4 157 SER 157 226 226 SER SER B . n 
D 4 158 HIS 158 227 227 HIS HIS B . n 
D 4 159 ILE 159 228 228 ILE ILE B . n 
D 4 160 GLY 160 229 229 GLY GLY B . n 
D 4 161 TRP 161 230 230 TRP TRP B . n 
D 4 162 ARG 162 231 231 ARG ARG B . n 
D 4 163 LYS 163 232 232 LYS LYS B . n 
D 4 164 GLU 164 233 233 GLU GLU B . n 
D 4 165 ALA 165 234 234 ALA ALA B . n 
D 4 166 LYS 166 235 235 LYS LYS B . n 
D 4 167 ARG 167 236 236 ARG ARG B . n 
D 4 168 LEU 168 237 237 LEU LEU B . n 
D 4 169 LEU 169 238 238 LEU LEU B . n 
D 4 170 LEU 170 239 239 LEU LEU B . n 
D 4 171 VAL 171 240 240 VAL VAL B . n 
D 4 172 MET 172 241 241 MET MET B . n 
D 4 173 THR 173 242 242 THR THR B . n 
D 4 174 ASP 174 243 243 ASP ASP B . n 
D 4 175 GLN 175 244 244 GLN GLN B . n 
D 4 176 THR 176 245 245 THR THR B . n 
D 4 177 SER 177 246 246 SER SER B . n 
D 4 178 HIS 178 247 247 HIS HIS B . n 
D 4 179 LEU 179 248 248 LEU LEU B . n 
D 4 180 ALA 180 249 249 ALA ALA B . n 
D 4 181 LEU 181 250 250 LEU LEU B . n 
D 4 182 ASP 182 251 251 ASP ASP B . n 
D 4 183 SER 183 252 252 SER SER B . n 
D 4 184 LYS 184 253 253 LYS LYS B . n 
D 4 185 LEU 185 254 254 LEU LEU B . n 
D 4 186 ALA 186 255 255 ALA ALA B . n 
D 4 187 GLY 187 256 256 GLY GLY B . n 
D 4 188 ILE 188 257 257 ILE ILE B . n 
D 4 189 VAL 189 258 258 VAL VAL B . n 
D 4 190 VAL 190 259 259 VAL VAL B . n 
D 4 191 PRO 191 260 260 PRO PRO B . n 
D 4 192 ASN 192 261 261 ASN ASN B . n 
D 4 193 ASP 193 262 262 ASP ASP B . n 
D 4 194 GLY 194 263 263 GLY GLY B . n 
D 4 195 ASN 195 264 264 ASN ASN B . n 
D 4 196 CYS 196 265 265 CYS CYS B . n 
D 4 197 HIS 197 266 266 HIS HIS B . n 
D 4 198 LEU 198 267 267 LEU LEU B . n 
D 4 199 LYS 199 268 268 LYS LYS B . n 
D 4 200 ASN 200 269 269 ASN ASN B . n 
D 4 201 ASN 201 270 270 ASN ASN B . n 
D 4 202 VAL 202 271 271 VAL VAL B . n 
D 4 203 TYR 203 272 272 TYR TYR B . n 
D 4 204 VAL 204 273 273 VAL VAL B . n 
D 4 205 LYS 205 274 274 LYS LYS B . n 
D 4 206 SER 206 275 275 SER SER B . n 
D 4 207 THR 207 276 276 THR THR B . n 
D 4 208 THR 208 277 277 THR THR B . n 
D 4 209 MET 209 278 278 MET MET B . n 
D 4 210 GLU 210 279 279 GLU GLU B . n 
D 4 211 HIS 211 280 280 HIS HIS B . n 
D 4 212 PRO 212 281 281 PRO PRO B . n 
D 4 213 SER 213 282 282 SER SER B . n 
D 4 214 LEU 214 283 283 LEU LEU B . n 
D 4 215 GLY 215 284 284 GLY GLY B . n 
D 4 216 GLN 216 285 285 GLN GLN B . n 
D 4 217 LEU 217 286 286 LEU LEU B . n 
D 4 218 SER 218 287 287 SER SER B . n 
D 4 219 GLU 219 288 288 GLU GLU B . n 
D 4 220 LYS 220 289 289 LYS LYS B . n 
D 4 221 LEU 221 290 290 LEU LEU B . n 
D 4 222 ILE 222 291 291 ILE ILE B . n 
D 4 223 ASP 223 292 292 ASP ASP B . n 
D 4 224 ASN 224 293 293 ASN ASN B . n 
D 4 225 ASN 225 294 294 ASN ASN B . n 
D 4 226 ILE 226 295 295 ILE ILE B . n 
D 4 227 ASN 227 296 296 ASN ASN B . n 
D 4 228 VAL 228 297 297 VAL VAL B . n 
D 4 229 ILE 229 298 298 ILE ILE B . n 
D 4 230 PHE 230 299 299 PHE PHE B . n 
D 4 231 ALA 231 300 300 ALA ALA B . n 
D 4 232 VAL 232 301 301 VAL VAL B . n 
D 4 233 GLN 233 302 302 GLN GLN B . n 
D 4 234 GLY 234 303 303 GLY GLY B . n 
D 4 235 LYS 235 304 304 LYS LYS B . n 
D 4 236 GLN 236 305 305 GLN GLN B . n 
D 4 237 PHE 237 306 306 PHE PHE B . n 
D 4 238 HIS 238 307 307 HIS HIS B . n 
D 4 239 TRP 239 308 308 TRP TRP B . n 
D 4 240 TYR 240 309 309 TYR TYR B . n 
D 4 241 LYS 241 310 310 LYS LYS B . n 
D 4 242 ASP 242 311 311 ASP ASP B . n 
D 4 243 LEU 243 312 312 LEU LEU B . n 
D 4 244 LEU 244 313 313 LEU LEU B . n 
D 4 245 PRO 245 314 314 PRO PRO B . n 
D 4 246 LEU 246 315 315 LEU LEU B . n 
D 4 247 LEU 247 316 316 LEU LEU B . n 
D 4 248 PRO 248 317 317 PRO PRO B . n 
D 4 249 GLY 249 318 318 GLY GLY B . n 
D 4 250 THR 250 319 319 THR THR B . n 
D 4 251 ILE 251 320 320 ILE ILE B . n 
D 4 252 ALA 252 321 321 ALA ALA B . n 
D 4 253 GLY 253 322 322 GLY GLY B . n 
D 4 254 GLU 254 323 323 GLU GLU B . n 
D 4 255 ILE 255 324 324 ILE ILE B . n 
D 4 256 GLU 256 325 325 GLU GLU B . n 
D 4 257 SER 257 326 326 SER SER B . n 
D 4 258 LYS 258 327 327 LYS LYS B . n 
D 4 259 ALA 259 328 328 ALA ALA B . n 
D 4 260 ALA 260 329 329 ALA ALA B . n 
D 4 261 ASN 261 330 330 ASN ASN B . n 
D 4 262 LEU 262 331 331 LEU LEU B . n 
D 4 263 ASN 263 332 332 ASN ASN B . n 
D 4 264 ASN 264 333 333 ASN ASN B . n 
D 4 265 LEU 265 334 334 LEU LEU B . n 
D 4 266 VAL 266 335 335 VAL VAL B . n 
D 4 267 VAL 267 336 336 VAL VAL B . n 
D 4 268 GLU 268 337 337 GLU GLU B . n 
D 4 269 ALA 269 338 338 ALA ALA B . n 
D 4 270 TYR 270 339 339 TYR TYR B . n 
D 4 271 GLN 271 340 340 GLN GLN B . n 
D 4 272 LYS 272 341 341 LYS LYS B . n 
D 4 273 LEU 273 342 342 LEU LEU B . n 
D 4 274 ILE 274 343 343 ILE ILE B . n 
D 4 275 SER 275 344 344 SER SER B . n 
D 4 276 GLU 276 345 345 GLU GLU B . n 
D 4 277 VAL 277 346 346 VAL VAL B . n 
D 4 278 LYS 278 347 347 LYS LYS B . n 
D 4 279 VAL 279 348 348 VAL VAL B . n 
D 4 280 GLN 280 349 349 GLN GLN B . n 
D 4 281 VAL 281 350 350 VAL VAL B . n 
D 4 282 GLU 282 351 351 GLU GLU B . n 
D 4 283 ASN 283 352 352 ASN ASN B . n 
D 4 284 GLN 284 353 353 GLN GLN B . n 
D 4 285 VAL 285 354 354 VAL VAL B . n 
D 4 286 GLN 286 355 355 GLN GLN B . n 
D 4 287 GLY 287 356 356 GLY GLY B . n 
D 4 288 ILE 288 357 357 ILE ILE B . n 
D 4 289 TYR 289 358 358 TYR TYR B . n 
D 4 290 PHE 290 359 359 PHE PHE B . n 
D 4 291 ASN 291 360 360 ASN ASN B . n 
D 4 292 ILE 292 361 361 ILE ILE B . n 
D 4 293 THR 293 362 362 THR THR B . n 
D 4 294 ALA 294 363 363 ALA ALA B . n 
D 4 295 ILE 295 364 364 ILE ILE B . n 
D 4 296 CYS 296 365 365 CYS CYS B . n 
D 4 297 PRO 297 366 366 PRO PRO B . n 
D 4 298 ASP 298 367 367 ASP ASP B . n 
D 4 299 GLY 299 368 368 GLY GLY B . n 
D 4 300 SER 300 369 369 SER SER B . n 
D 4 301 ARG 301 370 370 ARG ARG B . n 
D 4 302 LYS 302 371 371 LYS LYS B . n 
D 4 303 PRO 303 372 372 PRO PRO B . n 
D 4 304 GLY 304 373 373 GLY GLY B . n 
D 4 305 MET 305 374 374 MET MET B . n 
D 4 306 GLU 306 375 375 GLU GLU B . n 
D 4 307 GLY 307 376 376 GLY GLY B . n 
D 4 308 CYS 308 377 377 CYS CYS B . n 
D 4 309 ARG 309 378 378 ARG ARG B . n 
D 4 310 ASN 310 379 379 ASN ASN B . n 
D 4 311 VAL 311 380 380 VAL VAL B . n 
D 4 312 THR 312 381 381 THR THR B . n 
D 4 313 SER 313 382 382 SER SER B . n 
D 4 314 ASN 314 383 383 ASN ASN B . n 
D 4 315 ASP 315 384 384 ASP ASP B . n 
D 4 316 GLU 316 385 385 GLU GLU B . n 
D 4 317 VAL 317 386 386 VAL VAL B . n 
D 4 318 LEU 318 387 387 LEU LEU B . n 
D 4 319 PHE 319 388 388 PHE PHE B . n 
D 4 320 ASN 320 389 389 ASN ASN B . n 
D 4 321 VAL 321 390 390 VAL VAL B . n 
D 4 322 THR 322 391 391 THR THR B . n 
D 4 323 VAL 323 392 392 VAL VAL B . n 
D 4 324 THR 324 393 393 THR THR B . n 
D 4 325 MET 325 394 394 MET MET B . n 
D 4 326 LYS 326 395 395 LYS LYS B . n 
D 4 327 LYS 327 396 396 LYS LYS B . n 
D 4 328 CYS 328 397 397 CYS CYS B . n 
D 4 329 ASP 329 398 398 ASP ASP B . n 
D 4 330 VAL 330 399 ?   ?   ?   B . n 
D 4 331 THR 331 400 ?   ?   ?   B . n 
D 4 332 GLY 332 401 ?   ?   ?   B . n 
D 4 333 GLY 333 402 ?   ?   ?   B . n 
D 4 334 LYS 334 403 ?   ?   ?   B . n 
D 4 335 ASN 335 404 404 ASN ASN B . n 
D 4 336 TYR 336 405 405 TYR TYR B . n 
D 4 337 ALA 337 406 406 ALA ALA B . n 
D 4 338 ILE 338 407 407 ILE ILE B . n 
D 4 339 ILE 339 408 408 ILE ILE B . n 
D 4 340 LYS 340 409 409 LYS LYS B . n 
D 4 341 PRO 341 410 410 PRO PRO B . n 
D 4 342 ILE 342 411 411 ILE ILE B . n 
D 4 343 GLY 343 412 412 GLY GLY B . n 
D 4 344 PHE 344 413 413 PHE PHE B . n 
D 4 345 ASN 345 414 414 ASN ASN B . n 
D 4 346 GLU 346 415 415 GLU GLU B . n 
D 4 347 THR 347 416 416 THR THR B . n 
D 4 348 ALA 348 417 417 ALA ALA B . n 
D 4 349 LYS 349 418 418 LYS LYS B . n 
D 4 350 ILE 350 419 419 ILE ILE B . n 
D 4 351 HIS 351 420 420 HIS HIS B . n 
D 4 352 ILE 352 421 421 ILE ILE B . n 
# 
loop_
_pdbx_branch_scheme.asym_id 
_pdbx_branch_scheme.entity_id 
_pdbx_branch_scheme.mon_id 
_pdbx_branch_scheme.num 
_pdbx_branch_scheme.pdb_asym_id 
_pdbx_branch_scheme.pdb_mon_id 
_pdbx_branch_scheme.pdb_seq_num 
_pdbx_branch_scheme.auth_asym_id 
_pdbx_branch_scheme.auth_mon_id 
_pdbx_branch_scheme.auth_seq_num 
_pdbx_branch_scheme.hetero 
E 5 NAG 1 C NAG 1 A NAG 443 n 
E 5 NAG 2 C NAG 2 A NAG 444 n 
E 5 BMA 3 C BMA 3 A BMA 445 n 
E 5 MAN 4 C MAN 4 A MAN 446 n 
E 5 MAN 5 C MAN 5 A MAN 447 n 
# 
loop_
_pdbx_entity_instance_feature.ordinal 
_pdbx_entity_instance_feature.comp_id 
_pdbx_entity_instance_feature.asym_id 
_pdbx_entity_instance_feature.seq_num 
_pdbx_entity_instance_feature.auth_comp_id 
_pdbx_entity_instance_feature.auth_asym_id 
_pdbx_entity_instance_feature.auth_seq_num 
_pdbx_entity_instance_feature.feature_type 
_pdbx_entity_instance_feature.details 
1 BMA ? ? BMA ? ? 'SUBJECT OF INVESTIGATION' ? 
2 MAN ? ? MAN ? ? 'SUBJECT OF INVESTIGATION' ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
F 6 NAG 1 501 441 NAG NAG A . 
G 6 NAG 1 502 442 NAG NAG A . 
H 6 NAG 1 501 426 NAG NAG B . 
I 6 NAG 1 502 427 NAG NAG B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1   1 Y 1 A ASP 60  ? CG  ? A ASP 60  CG  
2   1 Y 1 A ASP 60  ? OD1 ? A ASP 60  OD1 
3   1 Y 1 A ASP 60  ? OD2 ? A ASP 60  OD2 
4   1 Y 1 A ARG 65  ? CG  ? A ARG 65  CG  
5   1 Y 1 A ARG 65  ? CD  ? A ARG 65  CD  
6   1 Y 1 A ARG 65  ? NE  ? A ARG 65  NE  
7   1 Y 1 A ARG 65  ? CZ  ? A ARG 65  CZ  
8   1 Y 1 A ARG 65  ? NH1 ? A ARG 65  NH1 
9   1 Y 1 A ARG 65  ? NH2 ? A ARG 65  NH2 
10  1 Y 1 A ARG 66  ? CG  ? A ARG 66  CG  
11  1 Y 1 A ARG 66  ? CD  ? A ARG 66  CD  
12  1 Y 1 A ARG 66  ? NE  ? A ARG 66  NE  
13  1 Y 1 A ARG 66  ? CZ  ? A ARG 66  CZ  
14  1 Y 1 A ARG 66  ? NH1 ? A ARG 66  NH1 
15  1 Y 1 A ARG 66  ? NH2 ? A ARG 66  NH2 
16  1 Y 1 A LYS 82  ? CG  ? A LYS 82  CG  
17  1 Y 1 A LYS 82  ? CD  ? A LYS 82  CD  
18  1 Y 1 A LYS 82  ? CE  ? A LYS 82  CE  
19  1 Y 1 A LYS 82  ? NZ  ? A LYS 82  NZ  
20  1 Y 1 A ASP 83  ? CG  ? A ASP 83  CG  
21  1 Y 1 A ASP 83  ? OD1 ? A ASP 83  OD1 
22  1 Y 1 A ASP 83  ? OD2 ? A ASP 83  OD2 
23  1 Y 1 A GLU 117 ? CG  ? A GLU 117 CG  
24  1 Y 1 A GLU 117 ? CD  ? A GLU 117 CD  
25  1 Y 1 A GLU 117 ? OE1 ? A GLU 117 OE1 
26  1 Y 1 A GLU 117 ? OE2 ? A GLU 117 OE2 
27  1 Y 1 A LYS 119 ? CG  ? A LYS 119 CG  
28  1 Y 1 A LYS 119 ? CD  ? A LYS 119 CD  
29  1 Y 1 A LYS 119 ? CE  ? A LYS 119 CE  
30  1 Y 1 A LYS 119 ? NZ  ? A LYS 119 NZ  
31  1 Y 1 A GLU 121 ? CG  ? A GLU 121 CG  
32  1 Y 1 A GLU 121 ? CD  ? A GLU 121 CD  
33  1 Y 1 A GLU 121 ? OE1 ? A GLU 121 OE1 
34  1 Y 1 A GLU 121 ? OE2 ? A GLU 121 OE2 
35  1 Y 1 A THR 134 ? OG1 ? A THR 134 OG1 
36  1 Y 1 A THR 134 ? CG2 ? A THR 134 CG2 
37  1 Y 1 A GLU 138 ? CG  ? A GLU 138 CG  
38  1 Y 1 A GLU 138 ? CD  ? A GLU 138 CD  
39  1 Y 1 A GLU 138 ? OE1 ? A GLU 138 OE1 
40  1 Y 1 A GLU 138 ? OE2 ? A GLU 138 OE2 
41  1 Y 1 A GLN 145 ? CG  ? A GLN 145 CG  
42  1 Y 1 A GLN 145 ? CD  ? A GLN 145 CD  
43  1 Y 1 A GLN 145 ? OE1 ? A GLN 145 OE1 
44  1 Y 1 A GLN 145 ? NE2 ? A GLN 145 NE2 
45  1 Y 1 A ASP 146 ? CG  ? A ASP 146 CG  
46  1 Y 1 A ASP 146 ? OD1 ? A ASP 146 OD1 
47  1 Y 1 A ASP 146 ? OD2 ? A ASP 146 OD2 
48  1 Y 1 A ASP 148 ? CG  ? A ASP 148 CG  
49  1 Y 1 A ASP 148 ? OD1 ? A ASP 148 OD1 
50  1 Y 1 A ASP 148 ? OD2 ? A ASP 148 OD2 
51  1 Y 1 A ASP 167 ? CG  ? A ASP 167 CG  
52  1 Y 1 A ASP 167 ? OD1 ? A ASP 167 OD1 
53  1 Y 1 A ASP 167 ? OD2 ? A ASP 167 OD2 
54  1 Y 1 A ASN 198 ? CG  ? A ASN 198 CG  
55  1 Y 1 A ASN 198 ? OD1 ? A ASN 198 OD1 
56  1 Y 1 A ASN 198 ? ND2 ? A ASN 198 ND2 
57  1 Y 1 A LYS 259 ? CG  ? A LYS 259 CG  
58  1 Y 1 A LYS 259 ? CD  ? A LYS 259 CD  
59  1 Y 1 A LYS 259 ? CE  ? A LYS 259 CE  
60  1 Y 1 A LYS 259 ? NZ  ? A LYS 259 NZ  
61  1 Y 1 A TYR 265 ? CG  ? A TYR 265 CG  
62  1 Y 1 A TYR 265 ? CD1 ? A TYR 265 CD1 
63  1 Y 1 A TYR 265 ? CD2 ? A TYR 265 CD2 
64  1 Y 1 A TYR 265 ? CE1 ? A TYR 265 CE1 
65  1 Y 1 A TYR 265 ? CE2 ? A TYR 265 CE2 
66  1 Y 1 A TYR 265 ? CZ  ? A TYR 265 CZ  
67  1 Y 1 A TYR 265 ? OH  ? A TYR 265 OH  
68  1 Y 1 A GLU 270 ? CG  ? A GLU 270 CG  
69  1 Y 1 A GLU 270 ? CD  ? A GLU 270 CD  
70  1 Y 1 A GLU 270 ? OE1 ? A GLU 270 OE1 
71  1 Y 1 A GLU 270 ? OE2 ? A GLU 270 OE2 
72  1 Y 1 A ASP 289 ? CG  ? A ASP 289 CG  
73  1 Y 1 A ASP 289 ? OD1 ? A ASP 289 OD1 
74  1 Y 1 A ASP 289 ? OD2 ? A ASP 289 OD2 
75  1 Y 1 A ASP 325 ? CG  ? A ASP 325 CG  
76  1 Y 1 A ASP 325 ? OD1 ? A ASP 325 OD1 
77  1 Y 1 A ASP 325 ? OD2 ? A ASP 325 OD2 
78  1 Y 1 A GLU 335 ? CG  ? A GLU 335 CG  
79  1 Y 1 A GLU 335 ? CD  ? A GLU 335 CD  
80  1 Y 1 A GLU 335 ? OE1 ? A GLU 335 OE1 
81  1 Y 1 A GLU 335 ? OE2 ? A GLU 335 OE2 
82  1 Y 1 A GLN 352 ? CG  ? A GLN 352 CG  
83  1 Y 1 A GLN 352 ? CD  ? A GLN 352 CD  
84  1 Y 1 A GLN 352 ? OE1 ? A GLN 352 OE1 
85  1 Y 1 A GLN 352 ? NE2 ? A GLN 352 NE2 
86  1 Y 1 A ASP 353 ? CG  ? A ASP 353 CG  
87  1 Y 1 A ASP 353 ? OD1 ? A ASP 353 OD1 
88  1 Y 1 A ASP 353 ? OD2 ? A ASP 353 OD2 
89  1 Y 1 A GLU 367 ? CG  ? A GLU 367 CG  
90  1 Y 1 A GLU 367 ? CD  ? A GLU 367 CD  
91  1 Y 1 A GLU 367 ? OE1 ? A GLU 367 OE1 
92  1 Y 1 A GLU 367 ? OE2 ? A GLU 367 OE2 
93  1 Y 1 A ASP 368 ? CG  ? A ASP 368 CG  
94  1 Y 1 A ASP 368 ? OD1 ? A ASP 368 OD1 
95  1 Y 1 A ASP 368 ? OD2 ? A ASP 368 OD2 
96  1 Y 1 A LYS 369 ? CG  ? A LYS 369 CG  
97  1 Y 1 A LYS 369 ? CD  ? A LYS 369 CD  
98  1 Y 1 A LYS 369 ? CE  ? A LYS 369 CE  
99  1 Y 1 A LYS 369 ? NZ  ? A LYS 369 NZ  
100 1 Y 1 A ARG 379 ? CG  ? A ARG 379 CG  
101 1 Y 1 A ARG 379 ? CD  ? A ARG 379 CD  
102 1 Y 1 A ARG 379 ? NE  ? A ARG 379 NE  
103 1 Y 1 A ARG 379 ? CZ  ? A ARG 379 CZ  
104 1 Y 1 A ARG 379 ? NH1 ? A ARG 379 NH1 
105 1 Y 1 A ARG 379 ? NH2 ? A ARG 379 NH2 
106 1 Y 1 A THR 381 ? OG1 ? A THR 381 OG1 
107 1 Y 1 A THR 381 ? CG2 ? A THR 381 CG2 
108 1 Y 1 A ARG 398 ? CG  ? A ARG 398 CG  
109 1 Y 1 A ARG 398 ? CD  ? A ARG 398 CD  
110 1 Y 1 A ARG 398 ? NE  ? A ARG 398 NE  
111 1 Y 1 A ARG 398 ? CZ  ? A ARG 398 CZ  
112 1 Y 1 A ARG 398 ? NH1 ? A ARG 398 NH1 
113 1 Y 1 A ARG 398 ? NH2 ? A ARG 398 NH2 
114 1 Y 1 A LYS 416 ? CG  ? A LYS 416 CG  
115 1 Y 1 A LYS 416 ? CD  ? A LYS 416 CD  
116 1 Y 1 A LYS 416 ? CE  ? A LYS 416 CE  
117 1 Y 1 A LYS 416 ? NZ  ? A LYS 416 NZ  
118 1 Y 1 H LYS 12  ? CG  ? B LYS 12  CG  
119 1 Y 1 H LYS 12  ? CD  ? B LYS 12  CD  
120 1 Y 1 H LYS 12  ? CE  ? B LYS 12  CE  
121 1 Y 1 H LYS 12  ? NZ  ? B LYS 12  NZ  
122 1 Y 1 H LYS 13  ? CG  ? B LYS 13  CG  
123 1 Y 1 H LYS 13  ? CD  ? B LYS 13  CD  
124 1 Y 1 H LYS 13  ? CE  ? B LYS 13  CE  
125 1 Y 1 H LYS 13  ? NZ  ? B LYS 13  NZ  
126 1 Y 1 H LYS 19  ? CG  ? B LYS 19  CG  
127 1 Y 1 H LYS 19  ? CD  ? B LYS 19  CD  
128 1 Y 1 H LYS 19  ? CE  ? B LYS 19  CE  
129 1 Y 1 H LYS 19  ? NZ  ? B LYS 19  NZ  
130 1 Y 1 H TYR 27  ? CG  ? B TYR 27  CG  
131 1 Y 1 H TYR 27  ? CD1 ? B TYR 27  CD1 
132 1 Y 1 H TYR 27  ? CD2 ? B TYR 27  CD2 
133 1 Y 1 H TYR 27  ? CE1 ? B TYR 27  CE1 
134 1 Y 1 H TYR 27  ? CE2 ? B TYR 27  CE2 
135 1 Y 1 H TYR 27  ? CZ  ? B TYR 27  CZ  
136 1 Y 1 H TYR 27  ? OH  ? B TYR 27  OH  
137 1 Y 1 H LYS 63  ? CG  ? B LYS 63  CG  
138 1 Y 1 H LYS 63  ? CD  ? B LYS 63  CD  
139 1 Y 1 H LYS 63  ? CE  ? B LYS 63  CE  
140 1 Y 1 H LYS 63  ? NZ  ? B LYS 63  NZ  
141 1 Y 1 L ARG 18  ? CG  ? C ARG 18  CG  
142 1 Y 1 L ARG 18  ? CD  ? C ARG 18  CD  
143 1 Y 1 L ARG 18  ? NE  ? C ARG 18  NE  
144 1 Y 1 L ARG 18  ? CZ  ? C ARG 18  CZ  
145 1 Y 1 L ARG 18  ? NH1 ? C ARG 18  NH1 
146 1 Y 1 L ARG 18  ? NH2 ? C ARG 18  NH2 
147 1 Y 1 L ASP 70  ? CG  ? C ASP 70  CG  
148 1 Y 1 L ASP 70  ? OD1 ? C ASP 70  OD1 
149 1 Y 1 L ASP 70  ? OD2 ? C ASP 70  OD2 
150 1 Y 1 L GLU 79  ? CG  ? C GLU 79  CG  
151 1 Y 1 L GLU 79  ? CD  ? C GLU 79  CD  
152 1 Y 1 L GLU 79  ? OE1 ? C GLU 79  OE1 
153 1 Y 1 L GLU 79  ? OE2 ? C GLU 79  OE2 
154 1 Y 1 L LYS 103 ? CG  ? C LYS 103 CG  
155 1 Y 1 L LYS 103 ? CD  ? C LYS 103 CD  
156 1 Y 1 L LYS 103 ? CE  ? C LYS 103 CE  
157 1 Y 1 L LYS 103 ? NZ  ? C LYS 103 NZ  
158 1 Y 1 B ASN 70  ? CG  ? D ASN 1   CG  
159 1 Y 1 B ASN 70  ? OD1 ? D ASN 1   OD1 
160 1 Y 1 B ASN 70  ? ND2 ? D ASN 1   ND2 
161 1 Y 1 B GLU 71  ? CG  ? D GLU 2   CG  
162 1 Y 1 B GLU 71  ? CD  ? D GLU 2   CD  
163 1 Y 1 B GLU 71  ? OE1 ? D GLU 2   OE1 
164 1 Y 1 B GLU 71  ? OE2 ? D GLU 2   OE2 
165 1 Y 1 B GLU 80  ? CG  ? D GLU 11  CG  
166 1 Y 1 B GLU 80  ? CD  ? D GLU 11  CD  
167 1 Y 1 B GLU 80  ? OE1 ? D GLU 11  OE1 
168 1 Y 1 B GLU 80  ? OE2 ? D GLU 11  OE2 
169 1 Y 1 B GLN 84  ? CG  ? D GLN 15  CG  
170 1 Y 1 B GLN 84  ? CD  ? D GLN 15  CD  
171 1 Y 1 B GLN 84  ? OE1 ? D GLN 15  OE1 
172 1 Y 1 B GLN 84  ? NE2 ? D GLN 15  NE2 
173 1 Y 1 B ARG 86  ? CG  ? D ARG 17  CG  
174 1 Y 1 B ARG 86  ? CD  ? D ARG 17  CD  
175 1 Y 1 B ARG 86  ? NE  ? D ARG 17  NE  
176 1 Y 1 B ARG 86  ? CZ  ? D ARG 17  CZ  
177 1 Y 1 B ARG 86  ? NH1 ? D ARG 17  NH1 
178 1 Y 1 B ARG 86  ? NH2 ? D ARG 17  NH2 
179 1 Y 1 B GLU 90  ? CG  ? D GLU 21  CG  
180 1 Y 1 B GLU 90  ? CD  ? D GLU 21  CD  
181 1 Y 1 B GLU 90  ? OE1 ? D GLU 21  OE1 
182 1 Y 1 B GLU 90  ? OE2 ? D GLU 21  OE2 
183 1 Y 1 B LYS 96  ? CG  ? D LYS 27  CG  
184 1 Y 1 B LYS 96  ? CD  ? D LYS 27  CD  
185 1 Y 1 B LYS 96  ? CE  ? D LYS 27  CE  
186 1 Y 1 B LYS 96  ? NZ  ? D LYS 27  NZ  
187 1 Y 1 B LYS 101 ? CG  ? D LYS 32  CG  
188 1 Y 1 B LYS 101 ? CD  ? D LYS 32  CD  
189 1 Y 1 B LYS 101 ? CE  ? D LYS 32  CE  
190 1 Y 1 B LYS 101 ? NZ  ? D LYS 32  NZ  
191 1 Y 1 B LYS 123 ? CG  ? D LYS 54  CG  
192 1 Y 1 B LYS 123 ? CD  ? D LYS 54  CD  
193 1 Y 1 B LYS 123 ? CE  ? D LYS 54  CE  
194 1 Y 1 B LYS 123 ? NZ  ? D LYS 54  NZ  
195 1 Y 1 B ASN 129 ? CG  ? D ASN 60  CG  
196 1 Y 1 B ASN 129 ? OD1 ? D ASN 60  OD1 
197 1 Y 1 B ASN 129 ? ND2 ? D ASN 60  ND2 
198 1 Y 1 B ASP 130 ? CG  ? D ASP 61  CG  
199 1 Y 1 B ASP 130 ? OD1 ? D ASP 61  OD1 
200 1 Y 1 B ASP 130 ? OD2 ? D ASP 61  OD2 
201 1 Y 1 B ARG 133 ? CG  ? D ARG 64  CG  
202 1 Y 1 B ARG 133 ? CD  ? D ARG 64  CD  
203 1 Y 1 B ARG 133 ? NE  ? D ARG 64  NE  
204 1 Y 1 B ARG 133 ? CZ  ? D ARG 64  CZ  
205 1 Y 1 B ARG 133 ? NH1 ? D ARG 64  NH1 
206 1 Y 1 B ARG 133 ? NH2 ? D ARG 64  NH2 
207 1 Y 1 B PHE 137 ? CG  ? D PHE 68  CG  
208 1 Y 1 B PHE 137 ? CD1 ? D PHE 68  CD1 
209 1 Y 1 B PHE 137 ? CD2 ? D PHE 68  CD2 
210 1 Y 1 B PHE 137 ? CE1 ? D PHE 68  CE1 
211 1 Y 1 B PHE 137 ? CE2 ? D PHE 68  CE2 
212 1 Y 1 B PHE 137 ? CZ  ? D PHE 68  CZ  
213 1 Y 1 B GLU 163 ? CG  ? D GLU 94  CG  
214 1 Y 1 B GLU 163 ? CD  ? D GLU 94  CD  
215 1 Y 1 B GLU 163 ? OE1 ? D GLU 94  OE1 
216 1 Y 1 B GLU 163 ? OE2 ? D GLU 94  OE2 
217 1 Y 1 B ARG 164 ? CG  ? D ARG 95  CG  
218 1 Y 1 B ARG 164 ? CD  ? D ARG 95  CD  
219 1 Y 1 B ARG 164 ? NE  ? D ARG 95  NE  
220 1 Y 1 B ARG 164 ? CZ  ? D ARG 95  CZ  
221 1 Y 1 B ARG 164 ? NH1 ? D ARG 95  NH1 
222 1 Y 1 B ARG 164 ? NH2 ? D ARG 95  NH2 
223 1 Y 1 B GLN 168 ? CG  ? D GLN 99  CG  
224 1 Y 1 B GLN 168 ? CD  ? D GLN 99  CD  
225 1 Y 1 B GLN 168 ? OE1 ? D GLN 99  OE1 
226 1 Y 1 B GLN 168 ? NE2 ? D GLN 99  NE2 
227 1 Y 1 B ASP 171 ? CG  ? D ASP 102 CG  
228 1 Y 1 B ASP 171 ? OD1 ? D ASP 102 OD1 
229 1 Y 1 B ASP 171 ? OD2 ? D ASP 102 OD2 
230 1 Y 1 B GLU 190 ? CG  ? D GLU 121 CG  
231 1 Y 1 B GLU 190 ? CD  ? D GLU 121 CD  
232 1 Y 1 B GLU 190 ? OE1 ? D GLU 121 OE1 
233 1 Y 1 B GLU 190 ? OE2 ? D GLU 121 OE2 
234 1 Y 1 B GLU 196 ? CG  ? D GLU 127 CG  
235 1 Y 1 B GLU 196 ? CD  ? D GLU 127 CD  
236 1 Y 1 B GLU 196 ? OE1 ? D GLU 127 OE1 
237 1 Y 1 B GLU 196 ? OE2 ? D GLU 127 OE2 
238 1 Y 1 B LYS 268 ? CG  ? D LYS 199 CG  
239 1 Y 1 B LYS 268 ? CD  ? D LYS 199 CD  
240 1 Y 1 B LYS 268 ? CE  ? D LYS 199 CE  
241 1 Y 1 B LYS 268 ? NZ  ? D LYS 199 NZ  
242 1 Y 1 B GLU 288 ? CG  ? D GLU 219 CG  
243 1 Y 1 B GLU 288 ? CD  ? D GLU 219 CD  
244 1 Y 1 B GLU 288 ? OE1 ? D GLU 219 OE1 
245 1 Y 1 B GLU 288 ? OE2 ? D GLU 219 OE2 
246 1 Y 1 B ASP 292 ? CG  ? D ASP 223 CG  
247 1 Y 1 B ASP 292 ? OD1 ? D ASP 223 OD1 
248 1 Y 1 B ASP 292 ? OD2 ? D ASP 223 OD2 
249 1 Y 1 B LYS 304 ? CG  ? D LYS 235 CG  
250 1 Y 1 B LYS 304 ? CD  ? D LYS 235 CD  
251 1 Y 1 B LYS 304 ? CE  ? D LYS 235 CE  
252 1 Y 1 B LYS 304 ? NZ  ? D LYS 235 NZ  
253 1 Y 1 B GLU 325 ? CG  ? D GLU 256 CG  
254 1 Y 1 B GLU 325 ? CD  ? D GLU 256 CD  
255 1 Y 1 B GLU 325 ? OE1 ? D GLU 256 OE1 
256 1 Y 1 B GLU 325 ? OE2 ? D GLU 256 OE2 
257 1 Y 1 B LYS 327 ? CG  ? D LYS 258 CG  
258 1 Y 1 B LYS 327 ? CD  ? D LYS 258 CD  
259 1 Y 1 B LYS 327 ? CE  ? D LYS 258 CE  
260 1 Y 1 B LYS 327 ? NZ  ? D LYS 258 NZ  
261 1 Y 1 B LYS 341 ? CG  ? D LYS 272 CG  
262 1 Y 1 B LYS 341 ? CD  ? D LYS 272 CD  
263 1 Y 1 B LYS 341 ? CE  ? D LYS 272 CE  
264 1 Y 1 B LYS 341 ? NZ  ? D LYS 272 NZ  
265 1 Y 1 B GLU 345 ? CG  ? D GLU 276 CG  
266 1 Y 1 B GLU 345 ? CD  ? D GLU 276 CD  
267 1 Y 1 B GLU 345 ? OE1 ? D GLU 276 OE1 
268 1 Y 1 B GLU 345 ? OE2 ? D GLU 276 OE2 
269 1 Y 1 B GLU 351 ? CG  ? D GLU 282 CG  
270 1 Y 1 B GLU 351 ? CD  ? D GLU 282 CD  
271 1 Y 1 B GLU 351 ? OE1 ? D GLU 282 OE1 
272 1 Y 1 B GLU 351 ? OE2 ? D GLU 282 OE2 
273 1 Y 1 B GLN 353 ? CG  ? D GLN 284 CG  
274 1 Y 1 B GLN 353 ? CD  ? D GLN 284 CD  
275 1 Y 1 B GLN 353 ? OE1 ? D GLN 284 OE1 
276 1 Y 1 B GLN 353 ? NE2 ? D GLN 284 NE2 
277 1 Y 1 B GLN 355 ? CG  ? D GLN 286 CG  
278 1 Y 1 B GLN 355 ? CD  ? D GLN 286 CD  
279 1 Y 1 B GLN 355 ? OE1 ? D GLN 286 OE1 
280 1 Y 1 B GLN 355 ? NE2 ? D GLN 286 NE2 
281 1 Y 1 B ARG 378 ? CG  ? D ARG 309 CG  
282 1 Y 1 B ARG 378 ? CD  ? D ARG 309 CD  
283 1 Y 1 B ARG 378 ? NE  ? D ARG 309 NE  
284 1 Y 1 B ARG 378 ? CZ  ? D ARG 309 CZ  
285 1 Y 1 B ARG 378 ? NH1 ? D ARG 309 NH1 
286 1 Y 1 B ARG 378 ? NH2 ? D ARG 309 NH2 
287 1 Y 1 B GLU 385 ? CG  ? D GLU 316 CG  
288 1 Y 1 B GLU 385 ? CD  ? D GLU 316 CD  
289 1 Y 1 B GLU 385 ? OE1 ? D GLU 316 OE1 
290 1 Y 1 B GLU 385 ? OE2 ? D GLU 316 OE2 
291 1 Y 1 B LYS 395 ? CG  ? D LYS 326 CG  
292 1 Y 1 B LYS 395 ? CD  ? D LYS 326 CD  
293 1 Y 1 B LYS 395 ? CE  ? D LYS 326 CE  
294 1 Y 1 B LYS 395 ? NZ  ? D LYS 326 NZ  
295 1 Y 1 B LYS 396 ? CG  ? D LYS 327 CG  
296 1 Y 1 B LYS 396 ? CD  ? D LYS 327 CD  
297 1 Y 1 B LYS 396 ? CE  ? D LYS 327 CE  
298 1 Y 1 B LYS 396 ? NZ  ? D LYS 327 NZ  
299 1 Y 1 B TYR 405 ? CG  ? D TYR 336 CG  
300 1 Y 1 B TYR 405 ? CD1 ? D TYR 336 CD1 
301 1 Y 1 B TYR 405 ? CD2 ? D TYR 336 CD2 
302 1 Y 1 B TYR 405 ? CE1 ? D TYR 336 CE1 
303 1 Y 1 B TYR 405 ? CE2 ? D TYR 336 CE2 
304 1 Y 1 B TYR 405 ? CZ  ? D TYR 336 CZ  
305 1 Y 1 B TYR 405 ? OH  ? D TYR 336 OH  
306 1 Y 1 B GLU 415 ? CG  ? D GLU 346 CG  
307 1 Y 1 B GLU 415 ? CD  ? D GLU 346 CD  
308 1 Y 1 B GLU 415 ? OE1 ? D GLU 346 OE1 
309 1 Y 1 B GLU 415 ? OE2 ? D GLU 346 OE2 
310 1 Y 1 B LYS 418 ? CG  ? D LYS 349 CG  
311 1 Y 1 B LYS 418 ? CD  ? D LYS 349 CD  
312 1 Y 1 B LYS 418 ? CE  ? D LYS 349 CE  
313 1 Y 1 B LYS 418 ? NZ  ? D LYS 349 NZ  
314 1 Y 1 B HIS 420 ? CG  ? D HIS 351 CG  
315 1 Y 1 B HIS 420 ? ND1 ? D HIS 351 ND1 
316 1 Y 1 B HIS 420 ? CD2 ? D HIS 351 CD2 
317 1 Y 1 B HIS 420 ? CE1 ? D HIS 351 CE1 
318 1 Y 1 B HIS 420 ? NE2 ? D HIS 351 NE2 
# 
_cell.angle_alpha                  90.00 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.00 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.00 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9IND 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     1.00 
_cell.length_a_esd                 ? 
_cell.length_b                     1.00 
_cell.length_b_esd                 ? 
_cell.length_c                     1.00 
_cell.length_c_esd                 ? 
_cell.volume                       ? 
_cell.volume_esd                   ? 
_cell.Z_PDB                        ? 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9IND 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                1 
_symmetry.space_group_name_Hall            ? 
_symmetry.space_group_name_H-M             'P 1' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9IND 
_exptl.crystals_number            ? 
_exptl.details                    ? 
_exptl.method                     'ELECTRON MICROSCOPY' 
_exptl.method_details             ? 
# 
_struct.entry_id                     9IND 
_struct.title                        'Integrin alpha-v beta-8 in complex with the Fab of 130H2' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9IND 
_struct_keywords.text            
'Cryo-EM, Integrin, Complex, SIGNALING PROTEIN/IMMUNE SYSTEM, SIGNALING PROTEIN-IMMUNE SYSTEM complex' 
_struct_keywords.pdbx_keywords   'SIGNALING PROTEIN/IMMUNE SYSTEM' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
E N N 5 ? 
F N N 6 ? 
G N N 6 ? 
H N N 6 ? 
I N N 6 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP ITAV_HUMAN P06756 ? 1 
;FNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDY
AKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFS
IDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFV
SGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQ
RASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSM
PPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPV
;
31  
2 PDB 9IND       9IND   ? 2 ? 1   
3 PDB 9IND       9IND   ? 3 ? 1   
4 UNP ITB8_HUMAN P26012 ? 4 
;NEINTQVTPGEVSIQLRPGAEANFMLKVHPLKKYPVDLYYLVDVSASMHNNIEKLNSVGNDLSRKMAFFSRDFRLGFGSY
VDKTVSPYISIHPERIHNQCSDYNLDCMPPHGYIHVLSLTENITEFEKAVHRQKISGNIDTPEGGFDAMLQAAVCESHIG
WRKEAKRLLLVMTDQTSHLALDSKLAGIVVPNDGNCHLKNNVYVKSTTMEHPSLGQLSEKLIDNNINVIFAVQGKQFHWY
KDLLPLLPGTIAGEIESKAANLNNLVVEAYQKLISEVKVQVENQVQGIYFNITAICPDGSRKPGMEGCRNVTSNDEVLFN
VTVTMKKCDVTGGKNYAIIKPIGFNETAKIHI
;
112 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9IND A 1 ? 440 ? P06756 31  ? 470 ? 1  440 
2 2 9IND H 1 ? 119 ? 9IND   1   ? 119 ? 1  119 
3 3 9IND L 1 ? 104 ? 9IND   1   ? 104 ? 1  104 
4 4 9IND B 1 ? 352 ? P26012 112 ? 463 ? 70 421 
# 
_struct_ref_seq_dif.align_id                     1 
_struct_ref_seq_dif.pdbx_pdb_id_code             9IND 
_struct_ref_seq_dif.mon_id                       TRP 
_struct_ref_seq_dif.pdbx_pdb_strand_id           A 
_struct_ref_seq_dif.seq_num                      419 
_struct_ref_seq_dif.pdbx_pdb_ins_code            ? 
_struct_ref_seq_dif.pdbx_seq_db_name             UNP 
_struct_ref_seq_dif.pdbx_seq_db_accession_code   P06756 
_struct_ref_seq_dif.db_mon_id                    TYR 
_struct_ref_seq_dif.pdbx_seq_db_seq_num          449 
_struct_ref_seq_dif.details                      conflict 
_struct_ref_seq_dif.pdbx_auth_seq_num            419 
_struct_ref_seq_dif.pdbx_ordinal                 1 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   tetrameric 
_pdbx_struct_assembly.oligomeric_count     4 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'electron microscopy' 
_pdbx_struct_assembly_auth_evidence.details                'not applicable' 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0 
_pdbx_struct_oper_list.matrix[1][2]         0.0 
_pdbx_struct_oper_list.matrix[1][3]         0.0 
_pdbx_struct_oper_list.vector[1]            0.0 
_pdbx_struct_oper_list.matrix[2][1]         0.0 
_pdbx_struct_oper_list.matrix[2][2]         1.0 
_pdbx_struct_oper_list.matrix[2][3]         0.0 
_pdbx_struct_oper_list.vector[2]            0.0 
_pdbx_struct_oper_list.matrix[3][1]         0.0 
_pdbx_struct_oper_list.matrix[3][2]         0.0 
_pdbx_struct_oper_list.matrix[3][3]         1.0 
_pdbx_struct_oper_list.vector[3]            0.0 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 GLY A 175 ? GLN A 180 ? GLY A 175 GLN A 180 1 ? 6  
HELX_P HELX_P2  AA2 VAL A 188 ? LYS A 194 ? VAL A 188 LYS A 194 1 ? 7  
HELX_P HELX_P3  AA3 GLN A 214 ? ASP A 218 ? GLN A 214 ASP A 218 5 ? 5  
HELX_P HELX_P4  AA4 ARG A 245 ? LEU A 250 ? ARG A 245 LEU A 250 1 ? 6  
HELX_P HELX_P5  AA5 GLY A 366 ? LYS A 370 ? GLY A 366 LYS A 370 5 ? 5  
HELX_P HELX_P6  AA6 ARG B 87  ? THR B 91  ? ARG H 87  THR H 91  5 ? 5  
HELX_P HELX_P7  AA7 GLU C 79  ? PHE C 83  ? GLU L 79  PHE L 83  5 ? 5  
HELX_P HELX_P8  AA8 SER D 45  ? SER D 47  ? SER B 114 SER B 116 5 ? 3  
HELX_P HELX_P9  AA9 MET D 48  ? LYS D 54  ? MET B 117 LYS B 123 1 ? 7  
HELX_P HELX_P10 AB1 SER D 57  ? MET D 66  ? SER B 126 MET B 135 1 ? 10 
HELX_P HELX_P11 AB2 HIS D 92  ? TYR D 103 ? HIS B 161 TYR B 172 1 ? 12 
HELX_P HELX_P12 AB3 ASN D 122 ? GLN D 133 ? ASN B 191 GLN B 202 1 ? 12 
HELX_P HELX_P13 AB4 GLY D 144 ? CYS D 155 ? GLY B 213 CYS B 224 1 ? 12 
HELX_P HELX_P14 AB5 CYS D 155 ? GLY D 160 ? CYS B 224 GLY B 229 1 ? 6  
HELX_P HELX_P15 AB6 LEU D 181 ? GLY D 187 ? LEU B 250 GLY B 256 5 ? 7  
HELX_P HELX_P16 AB7 SER D 213 ? ASN D 224 ? SER B 282 ASN B 293 1 ? 12 
HELX_P HELX_P17 AB8 GLN D 236 ? LEU D 244 ? GLN B 305 LEU B 313 1 ? 9  
HELX_P HELX_P18 AB9 ASN D 261 ? GLU D 276 ? ASN B 330 GLU B 345 1 ? 16 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
disulf1 disulf ?    ? A CYS 59  SG  ? ? ? 1_555 A CYS 67  SG ? ? A CYS 59  A CYS 67  1_555 ? ? ? ? ? ? ? 2.030 ? ?               
disulf2 disulf ?    ? A CYS 108 SG  ? ? ? 1_555 A CYS 128 SG ? ? A CYS 108 A CYS 128 1_555 ? ? ? ? ? ? ? 2.021 ? ?               
disulf3 disulf ?    ? A CYS 142 SG  ? ? ? 1_555 A CYS 155 SG ? ? A CYS 142 A CYS 155 1_555 ? ? ? ? ? ? ? 2.040 ? ?               
disulf4 disulf ?    ? B CYS 22  SG  ? ? ? 1_555 B CYS 96  SG ? ? H CYS 22  H CYS 96  1_555 ? ? ? ? ? ? ? 2.031 ? ?               
disulf5 disulf ?    ? C CYS 23  SG  ? ? ? 1_555 C CYS 88  SG ? ? L CYS 23  L CYS 88  1_555 ? ? ? ? ? ? ? 2.023 ? ?               
disulf6 disulf ?    ? D CYS 100 SG  ? ? ? 1_555 D CYS 107 SG ? ? B CYS 169 B CYS 176 1_555 ? ? ? ? ? ? ? 2.030 ? ?               
disulf7 disulf ?    ? D CYS 155 SG  ? ? ? 1_555 D CYS 196 SG ? ? B CYS 224 B CYS 265 1_555 ? ? ? ? ? ? ? 2.031 ? ?               
disulf8 disulf ?    ? D CYS 296 SG  ? ? ? 1_555 D CYS 308 SG ? ? B CYS 365 B CYS 377 1_555 ? ? ? ? ? ? ? 2.031 ? ?               
covale1 covale one  ? A ASN 44  ND2 ? ? ? 1_555 F NAG .   C1 ? ? A ASN 44  A NAG 501 1_555 ? ? ? ? ? ? ? 1.434 ? N-Glycosylation 
covale2 covale one  ? A ASN 260 ND2 ? ? ? 1_555 G NAG .   C1 ? ? A ASN 260 A NAG 502 1_555 ? ? ? ? ? ? ? 1.434 ? N-Glycosylation 
covale3 covale one  ? A ASN 266 ND2 ? ? ? 1_555 E NAG .   C1 ? ? A ASN 266 C NAG 1   1_555 ? ? ? ? ? ? ? 1.431 ? N-Glycosylation 
covale4 covale one  ? D ASN 320 ND2 ? ? ? 1_555 H NAG .   C1 ? ? B ASN 389 B NAG 501 1_555 ? ? ? ? ? ? ? 1.437 ? N-Glycosylation 
covale5 covale one  ? D ASN 345 ND2 ? ? ? 1_555 I NAG .   C1 ? ? B ASN 414 B NAG 502 1_555 ? ? ? ? ? ? ? 1.427 ? N-Glycosylation 
covale6 covale both ? E NAG .   O4  ? ? ? 1_555 E NAG .   C1 ? ? C NAG 1   C NAG 2   1_555 ? ? ? ? ? ? ? 1.427 ? ?               
covale7 covale both ? E NAG .   O4  ? ? ? 1_555 E BMA .   C1 ? ? C NAG 2   C BMA 3   1_555 ? ? ? ? ? ? ? 1.445 ? ?               
covale8 covale both ? E BMA .   O3  ? ? ? 1_555 E MAN .   C1 ? ? C BMA 3   C MAN 4   1_555 ? ? ? ? ? ? ? 1.438 ? ?               
covale9 covale both ? E BMA .   O6  ? ? ? 1_555 E MAN .   C1 ? ? C BMA 3   C MAN 5   1_555 ? ? ? ? ? ? ? 1.455 ? ?               
# 
loop_
_struct_conn_type.id 
_struct_conn_type.criteria 
_struct_conn_type.reference 
disulf ? ? 
covale ? ? 
# 
loop_
_pdbx_modification_feature.ordinal 
_pdbx_modification_feature.label_comp_id 
_pdbx_modification_feature.label_asym_id 
_pdbx_modification_feature.label_seq_id 
_pdbx_modification_feature.label_alt_id 
_pdbx_modification_feature.modified_residue_label_comp_id 
_pdbx_modification_feature.modified_residue_label_asym_id 
_pdbx_modification_feature.modified_residue_label_seq_id 
_pdbx_modification_feature.modified_residue_label_alt_id 
_pdbx_modification_feature.auth_comp_id 
_pdbx_modification_feature.auth_asym_id 
_pdbx_modification_feature.auth_seq_id 
_pdbx_modification_feature.PDB_ins_code 
_pdbx_modification_feature.symmetry 
_pdbx_modification_feature.modified_residue_auth_comp_id 
_pdbx_modification_feature.modified_residue_auth_asym_id 
_pdbx_modification_feature.modified_residue_auth_seq_id 
_pdbx_modification_feature.modified_residue_PDB_ins_code 
_pdbx_modification_feature.modified_residue_symmetry 
_pdbx_modification_feature.comp_id_linking_atom 
_pdbx_modification_feature.modified_residue_id_linking_atom 
_pdbx_modification_feature.modified_residue_id 
_pdbx_modification_feature.ref_pcm_id 
_pdbx_modification_feature.ref_comp_id 
_pdbx_modification_feature.type 
_pdbx_modification_feature.category 
1  NAG E .   ? ASN A 266 ? NAG C 1   ? 1_555 ASN A 266 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
2  NAG F .   ? ASN A 44  ? NAG A 501 ? 1_555 ASN A 44  ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
3  NAG G .   ? ASN A 260 ? NAG A 502 ? 1_555 ASN A 260 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
4  NAG H .   ? ASN D 320 ? NAG B 501 ? 1_555 ASN B 389 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
5  NAG I .   ? ASN D 345 ? NAG B 502 ? 1_555 ASN B 414 ? 1_555 C1 ND2 ASN 1 NAG N-Glycosylation Carbohydrate       
6  CYS A 59  ? CYS A 67  ? CYS A 59  ? 1_555 CYS A 67  ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
7  CYS A 108 ? CYS A 128 ? CYS A 108 ? 1_555 CYS A 128 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
8  CYS A 142 ? CYS A 155 ? CYS A 142 ? 1_555 CYS A 155 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
9  CYS B 22  ? CYS B 96  ? CYS H 22  ? 1_555 CYS H 96  ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
10 CYS C 23  ? CYS C 88  ? CYS L 23  ? 1_555 CYS L 88  ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
11 CYS D 100 ? CYS D 107 ? CYS B 169 ? 1_555 CYS B 176 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
12 CYS D 155 ? CYS D 196 ? CYS B 224 ? 1_555 CYS B 265 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
13 CYS D 296 ? CYS D 308 ? CYS B 365 ? 1_555 CYS B 377 ? 1_555 SG SG  .   . .   None            'Disulfide bridge' 
# 
loop_
_struct_mon_prot_cis.pdbx_id 
_struct_mon_prot_cis.label_comp_id 
_struct_mon_prot_cis.label_seq_id 
_struct_mon_prot_cis.label_asym_id 
_struct_mon_prot_cis.label_alt_id 
_struct_mon_prot_cis.pdbx_PDB_ins_code 
_struct_mon_prot_cis.auth_comp_id 
_struct_mon_prot_cis.auth_seq_id 
_struct_mon_prot_cis.auth_asym_id 
_struct_mon_prot_cis.pdbx_label_comp_id_2 
_struct_mon_prot_cis.pdbx_label_seq_id_2 
_struct_mon_prot_cis.pdbx_label_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_ins_code_2 
_struct_mon_prot_cis.pdbx_auth_comp_id_2 
_struct_mon_prot_cis.pdbx_auth_seq_id_2 
_struct_mon_prot_cis.pdbx_auth_asym_id_2 
_struct_mon_prot_cis.pdbx_PDB_model_num 
_struct_mon_prot_cis.pdbx_omega_angle 
1 SER 7  C . ? SER 7   L PRO 8  C ? PRO 8   L 1 -0.28 
2 TRP 94 C . ? TRP 94  L PRO 95 C ? PRO 95  L 1 0.25  
3 THR 8  D . ? THR 77  B PRO 9  D ? PRO 78  B 1 -1.07 
4 SER 86 D . ? SER 155 B PRO 87 D ? PRO 156 B 1 2.16  
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 4 ? 
AA3 ? 2 ? 
AA4 ? 3 ? 
AA5 ? 4 ? 
AA6 ? 4 ? 
AA7 ? 4 ? 
AA8 ? 4 ? 
AA9 ? 2 ? 
AB1 ? 4 ? 
AB2 ? 2 ? 
AB3 ? 4 ? 
AB4 ? 6 ? 
AB5 ? 4 ? 
AB6 ? 4 ? 
AB7 ? 5 ? 
AB8 ? 5 ? 
AB9 ? 4 ? 
AC1 ? 6 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA5 1 2 ? anti-parallel 
AA5 2 3 ? anti-parallel 
AA5 3 4 ? anti-parallel 
AA6 1 2 ? anti-parallel 
AA6 2 3 ? anti-parallel 
AA6 3 4 ? anti-parallel 
AA7 1 2 ? anti-parallel 
AA7 2 3 ? anti-parallel 
AA7 3 4 ? anti-parallel 
AA8 1 2 ? anti-parallel 
AA8 2 3 ? anti-parallel 
AA8 3 4 ? anti-parallel 
AA9 1 2 ? anti-parallel 
AB1 1 2 ? anti-parallel 
AB1 2 3 ? anti-parallel 
AB1 3 4 ? anti-parallel 
AB2 1 2 ? anti-parallel 
AB3 1 2 ? anti-parallel 
AB3 2 3 ? anti-parallel 
AB3 3 4 ? anti-parallel 
AB4 1 2 ? parallel      
AB4 2 3 ? anti-parallel 
AB4 3 4 ? anti-parallel 
AB4 4 5 ? anti-parallel 
AB4 5 6 ? anti-parallel 
AB5 1 2 ? parallel      
AB5 2 3 ? anti-parallel 
AB5 3 4 ? anti-parallel 
AB6 1 2 ? anti-parallel 
AB6 2 3 ? anti-parallel 
AB6 3 4 ? anti-parallel 
AB7 1 2 ? anti-parallel 
AB7 2 3 ? anti-parallel 
AB7 3 4 ? anti-parallel 
AB7 4 5 ? anti-parallel 
AB8 1 2 ? anti-parallel 
AB8 2 3 ? anti-parallel 
AB8 3 4 ? anti-parallel 
AB8 4 5 ? anti-parallel 
AB9 1 2 ? parallel      
AB9 2 3 ? anti-parallel 
AB9 3 4 ? anti-parallel 
AC1 1 2 ? anti-parallel 
AC1 2 3 ? parallel      
AC1 3 4 ? parallel      
AC1 4 5 ? parallel      
AC1 5 6 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 9   ? SER A 12  ? ALA A 9   SER A 12  
AA1 2 ARG A 431 ? TYR A 435 ? ARG A 431 TYR A 435 
AA1 3 ASP A 421 ? ALA A 426 ? ASP A 421 ALA A 426 
AA1 4 SER A 407 ? THR A 412 ? SER A 407 THR A 412 
AA2 1 VAL A 23  ? PHE A 26  ? VAL A 23  PHE A 26  
AA2 2 PHE A 35  ? ALA A 40  ? PHE A 35  ALA A 40  
AA2 3 GLN A 55  ? ASP A 60  ? GLN A 55  ASP A 60  
AA2 4 CYS A 67  ? PRO A 69  ? CYS A 67  PRO A 69  
AA3 1 ASP A 79  ? ALA A 81  ? ASP A 79  ALA A 81  
AA3 2 ASP A 84  ? PRO A 85  ? ASP A 84  PRO A 85  
AA4 1 GLU A 87  ? PHE A 88  ? GLU A 87  PHE A 88  
AA4 2 HIS A 113 ? TRP A 114 ? HIS A 113 TRP A 114 
AA4 3 GLU A 123 ? PRO A 124 ? GLU A 123 PRO A 124 
AA5 1 VAL A 98  ? LYS A 101 ? VAL A 98  LYS A 101 
AA5 2 LYS A 104 ? ALA A 109 ? LYS A 104 ALA A 109 
AA5 3 THR A 127 ? ASP A 132 ? THR A 127 ASP A 132 
AA5 4 LYS A 135 ? TYR A 139 ? LYS A 135 TYR A 139 
AA6 1 SER A 160 ? PHE A 163 ? SER A 160 PHE A 163 
AA6 2 ARG A 168 ? GLY A 173 ? ARG A 168 GLY A 173 
AA6 3 GLN A 182 ? GLN A 187 ? GLN A 182 GLN A 187 
AA6 4 LEU A 208 ? ALA A 209 ? LEU A 208 ALA A 209 
AA7 1 SER A 225 ? GLY A 229 ? SER A 225 GLY A 229 
AA7 2 ASP A 238 ? VAL A 243 ? ASP A 238 VAL A 243 
AA7 3 MET A 252 ? TYR A 256 ? MET A 252 TYR A 256 
AA7 4 SER A 263 ? THR A 268 ? SER A 263 THR A 268 
AA8 1 VAL A 280 ? THR A 283 ? VAL A 280 THR A 283 
AA8 2 ASP A 292 ? ALA A 297 ? ASP A 292 ALA A 297 
AA8 3 GLN A 314 ? GLN A 320 ? GLN A 314 GLN A 320 
AA8 4 PHE A 326 ? ASN A 332 ? PHE A 326 ASN A 332 
AA9 1 MET A 301 ? ARG A 303 ? MET A 301 ARG A 303 
AA9 2 LEU A 309 ? GLU A 311 ? LEU A 309 GLU A 311 
AB1 1 ILE A 344 ? GLY A 348 ? ILE A 344 GLY A 348 
AB1 2 ASP A 357 ? ALA A 362 ? ASP A 357 ALA A 362 
AB1 3 ILE A 372 ? PHE A 376 ? ILE A 372 PHE A 376 
AB1 4 GLN A 389 ? GLU A 392 ? GLN A 389 GLU A 392 
AB2 1 GLY A 378 ? ARG A 379 ? GLY A 378 ARG A 379 
AB2 2 GLY A 382 ? LEU A 383 ? GLY A 382 LEU A 383 
AB3 1 VAL B 5   ? GLN B 6   ? VAL H 5   GLN H 6   
AB3 2 SER B 17  ? LYS B 23  ? SER H 17  LYS H 23  
AB3 3 THR B 78  ? SER B 84  ? THR H 78  SER H 84  
AB3 4 VAL B 68  ? ASP B 73  ? VAL H 68  ASP H 73  
AB4 1 GLU B 10  ? VAL B 11  ? GLU H 10  VAL H 11  
AB4 2 THR B 113 ? THR B 116 ? THR H 113 THR H 116 
AB4 3 ALA B 92  ? TYR B 100 ? ALA H 92  TYR H 100 
AB4 4 GLY B 33  ? GLN B 39  ? GLY H 33  GLN H 39  
AB4 5 LEU B 45  ? TYR B 52  ? LEU H 45  TYR H 52  
AB4 6 THR B 58  ? TYR B 60  ? THR H 58  TYR H 60  
AB5 1 GLU B 10  ? VAL B 11  ? GLU H 10  VAL H 11  
AB5 2 THR B 113 ? THR B 116 ? THR H 113 THR H 116 
AB5 3 ALA B 92  ? TYR B 100 ? ALA H 92  TYR H 100 
AB5 4 SER B 103 ? TYR B 108 ? SER H 103 TYR H 108 
AB6 1 GLN C 6   ? SER C 7   ? GLN L 6   SER L 7   
AB6 2 ALA C 19  ? CYS C 23  ? ALA L 19  CYS L 23  
AB6 3 ASP C 70  ? ILE C 75  ? ASP L 70  ILE L 75  
AB6 4 PHE C 62  ? SER C 67  ? PHE L 62  SER L 67  
AB7 1 GLN C 53  ? SER C 54  ? GLN L 53  SER L 54  
AB7 2 ARG C 45  ? LYS C 49  ? ARG L 45  LYS L 49  
AB7 3 LEU C 33  ? GLN C 38  ? LEU L 33  GLN L 38  
AB7 4 VAL C 85  ? GLN C 90  ? VAL L 85  GLN L 90  
AB7 5 THR C 97  ? PHE C 98  ? THR L 97  PHE L 98  
AB8 1 VAL D 7   ? THR D 8   ? VAL B 76  THR B 77  
AB8 2 ALA D 22  ? VAL D 28  ? ALA B 91  VAL B 97  
AB8 3 VAL D 317 ? MET D 325 ? VAL B 386 MET B 394 
AB8 4 ILE D 288 ? ILE D 295 ? ILE B 357 ILE B 364 
AB8 5 ARG D 301 ? PRO D 303 ? ARG B 370 PRO B 372 
AB9 1 GLU D 11  ? SER D 13  ? GLU B 80  SER B 82  
AB9 2 LYS D 349 ? HIS D 351 ? LYS B 418 HIS B 420 
AB9 3 TYR D 336 ? PRO D 341 ? TYR B 405 PRO B 410 
AB9 4 VAL D 279 ? GLU D 282 ? VAL B 348 GLU B 351 
AC1 1 TYR D 113 ? THR D 120 ? TYR B 182 THR B 189 
AC1 2 SER D 70  ? TYR D 80  ? SER B 139 TYR B 149 
AC1 3 TYR D 34  ? ASP D 43  ? TYR B 103 ASP B 112 
AC1 4 LYS D 166 ? THR D 173 ? LYS B 235 THR B 242 
AC1 5 ILE D 226 ? VAL D 232 ? ILE B 295 VAL B 301 
AC1 6 THR D 250 ? GLU D 254 ? THR B 319 GLU B 323 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ALA A 9   ? N ALA A 9   O LEU A 434 ? O LEU A 434 
AA1 2 3 O TYR A 435 ? O TYR A 435 N LEU A 422 ? N LEU A 422 
AA1 3 4 O GLY A 425 ? O GLY A 425 N SER A 407 ? N SER A 407 
AA2 1 2 N PHE A 26  ? N PHE A 26  O PHE A 35  ? O PHE A 35  
AA2 2 3 N LEU A 36  ? N LEU A 36  O CYS A 59  ? O CYS A 59  
AA2 3 4 N LYS A 58  ? N LYS A 58  O GLN A 68  ? O GLN A 68  
AA3 1 2 N TYR A 80  ? N TYR A 80  O ASP A 84  ? O ASP A 84  
AA4 1 2 N PHE A 88  ? N PHE A 88  O HIS A 113 ? O HIS A 113 
AA4 2 3 N TRP A 114 ? N TRP A 114 O GLU A 123 ? O GLU A 123 
AA5 1 2 N ARG A 99  ? N ARG A 99  O LEU A 106 ? O LEU A 106 
AA5 2 3 N ALA A 107 ? N ALA A 107 O PHE A 129 ? O PHE A 129 
AA5 3 4 N CYS A 128 ? N CYS A 128 O TYR A 139 ? O TYR A 139 
AA6 1 2 N ASP A 162 ? N ASP A 162 O LEU A 170 ? O LEU A 170 
AA6 2 3 N LEU A 171 ? N LEU A 171 O ILE A 184 ? O ILE A 184 
AA6 3 4 N SER A 185 ? N SER A 185 O LEU A 208 ? O LEU A 208 
AA7 1 2 N SER A 225 ? N SER A 225 O GLY A 242 ? O GLY A 242 
AA7 2 3 N PHE A 239 ? N PHE A 239 O TYR A 256 ? O TYR A 256 
AA7 3 4 N ILE A 255 ? N ILE A 255 O LEU A 264 ? O LEU A 264 
AA8 1 2 N THR A 283 ? N THR A 283 O ASP A 292 ? O ASP A 292 
AA8 2 3 N ILE A 295 ? N ILE A 295 O SER A 316 ? O SER A 316 
AA8 3 4 N VAL A 317 ? N VAL A 317 O THR A 329 ? O THR A 329 
AA9 1 2 N ASP A 302 ? N ASP A 302 O GLN A 310 ? O GLN A 310 
AB1 1 2 N ALA A 345 ? N ALA A 345 O ALA A 359 ? O ALA A 359 
AB1 2 3 N ALA A 362 ? N ALA A 362 O ILE A 372 ? O ILE A 372 
AB1 3 4 N ILE A 375 ? N ILE A 375 O GLN A 389 ? O GLN A 389 
AB2 1 2 N ARG A 379 ? N ARG A 379 O GLY A 382 ? O GLY A 382 
AB3 1 2 N VAL B 5   ? N VAL H 5   O LYS B 23  ? O LYS H 23  
AB3 2 3 N CYS B 22  ? N CYS H 22  O VAL B 79  ? O VAL H 79  
AB3 3 4 O GLU B 82  ? O GLU H 82  N THR B 69  ? N THR H 69  
AB4 1 2 N GLU B 10  ? N GLU H 10  O THR B 114 ? O THR H 114 
AB4 2 3 O THR B 113 ? O THR H 113 N TYR B 94  ? N TYR H 94  
AB4 3 4 O ALA B 97  ? O ALA H 97  N ASN B 35  ? N ASN H 35  
AB4 4 5 N ARG B 38  ? N ARG H 38  O GLU B 46  ? O GLU H 46  
AB4 5 6 N TYR B 50  ? N TYR H 50  O GLU B 59  ? O GLU H 59  
AB5 1 2 N GLU B 10  ? N GLU H 10  O THR B 114 ? O THR H 114 
AB5 2 3 O THR B 113 ? O THR H 113 N TYR B 94  ? N TYR H 94  
AB5 3 4 N LEU B 98  ? N LEU H 98  O TYR B 108 ? O TYR H 108 
AB6 1 2 N SER C 7   ? N SER L 7   O SER C 22  ? O SER L 22  
AB6 2 3 N CYS C 23  ? N CYS L 23  O PHE C 71  ? O PHE L 71  
AB6 3 4 O THR C 72  ? O THR L 72  N SER C 65  ? N SER L 65  
AB7 1 2 O GLN C 53  ? O GLN L 53  N LYS C 49  ? N LYS L 49  
AB7 2 3 O LEU C 47  ? O LEU L 47  N TRP C 35  ? N TRP L 35  
AB7 3 4 N TYR C 36  ? N TYR L 36  O PHE C 87  ? O PHE L 87  
AB7 4 5 N GLN C 90  ? N GLN L 90  O THR C 97  ? O THR L 97  
AB8 1 2 N THR D 8   ? N THR B 77  O LYS D 27  ? O LYS B 96  
AB8 2 3 N ALA D 22  ? N ALA B 91  O VAL D 323 ? O VAL B 392 
AB8 3 4 O LEU D 318 ? O LEU B 387 N ILE D 295 ? N ILE B 364 
AB8 4 5 N ALA D 294 ? N ALA B 363 O LYS D 302 ? O LYS B 371 
AB9 1 2 N VAL D 12  ? N VAL B 81  O HIS D 351 ? O HIS B 420 
AB9 2 3 O ILE D 350 ? O ILE B 419 N ALA D 337 ? N ALA B 406 
AB9 3 4 O ILE D 338 ? O ILE B 407 N GLU D 282 ? N GLU B 351 
AC1 1 2 O THR D 120 ? O THR B 189 N LEU D 75  ? N LEU B 144 
AC1 2 3 O ARG D 74  ? O ARG B 143 N LEU D 38  ? N LEU B 107 
AC1 3 4 N PRO D 35  ? N PRO B 104 O LYS D 166 ? O LYS B 235 
AC1 4 5 N VAL D 171 ? N VAL B 240 O ILE D 229 ? O ILE B 298 
AC1 5 6 N PHE D 230 ? N PHE B 299 O GLY D 253 ? O GLY B 322 
# 
_pdbx_entry_details.entry_id                   9IND 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   Y 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 O B ASN 167 ? ? C B ASN 167 ? ? N B GLN 168 ? ? 133.39 122.70 10.69  1.60 Y 
2 1 O B GLN 168 ? ? C B GLN 168 ? ? N B CYS 169 ? ? 111.65 122.70 -11.05 1.60 Y 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 GLN A 102 ? ? 72.76   -19.86  
2  1 ASP A 103 ? ? -147.53 -17.59  
3  1 ASP A 148 ? ? -171.94 -172.48 
4  1 ALA A 166 ? ? -92.19  30.77   
5  1 ARG A 211 ? ? -117.32 -169.51 
6  1 ALA A 213 ? ? -124.15 -169.14 
7  1 ASN A 232 ? ? -140.76 26.74   
8  1 ASN A 260 ? ? -141.92 15.03   
9  1 ARG A 339 ? ? 61.63   61.22   
10 1 ALA H 16  ? ? -117.60 -166.08 
11 1 THR H 30  ? ? 73.37   -6.98   
12 1 ARG H 104 ? ? -93.23  50.99   
13 1 CYS L 23  ? ? -161.19 113.59  
14 1 ALA L 51  ? ? 71.37   -11.53  
15 1 SER L 52  ? ? -147.60 -0.80   
16 1 ILE B 72  ? ? -126.33 -51.98  
17 1 LYS B 102 ? ? 60.17   71.48   
18 1 ASN B 129 ? ? -93.18  -62.14  
19 1 VAL B 150 ? ? -121.13 -68.28  
20 1 THR B 153 ? ? -94.66  56.36   
21 1 VAL B 185 ? ? -96.00  -60.72  
22 1 LYS B 203 ? ? -118.47 -166.92 
23 1 SER B 205 ? ? -138.61 -158.63 
24 1 GLU B 233 ? ? -94.65  47.53   
25 1 GLU B 325 ? ? -76.52  -167.15 
# 
_pdbx_validate_peptide_omega.id               1 
_pdbx_validate_peptide_omega.PDB_model_num    1 
_pdbx_validate_peptide_omega.auth_comp_id_1   ASN 
_pdbx_validate_peptide_omega.auth_asym_id_1   H 
_pdbx_validate_peptide_omega.auth_seq_id_1    99 
_pdbx_validate_peptide_omega.PDB_ins_code_1   ? 
_pdbx_validate_peptide_omega.label_alt_id_1   ? 
_pdbx_validate_peptide_omega.auth_comp_id_2   TYR 
_pdbx_validate_peptide_omega.auth_asym_id_2   H 
_pdbx_validate_peptide_omega.auth_seq_id_2    100 
_pdbx_validate_peptide_omega.PDB_ins_code_2   ? 
_pdbx_validate_peptide_omega.label_alt_id_2   ? 
_pdbx_validate_peptide_omega.omega            148.76 
# 
_em_3d_fitting.id                1 
_em_3d_fitting.entry_id          9IND 
_em_3d_fitting.method            ? 
_em_3d_fitting.target_criteria   ? 
_em_3d_fitting.details           ? 
_em_3d_fitting.overall_b_value   ? 
_em_3d_fitting.ref_space         ? 
_em_3d_fitting.ref_protocol      ? 
# 
_em_3d_reconstruction.entry_id                    9IND 
_em_3d_reconstruction.id                          1 
_em_3d_reconstruction.method                      ? 
_em_3d_reconstruction.algorithm                   ? 
_em_3d_reconstruction.citation_id                 ? 
_em_3d_reconstruction.details                     ? 
_em_3d_reconstruction.resolution                  2.88 
_em_3d_reconstruction.resolution_method           'FSC 0.143 CUT-OFF' 
_em_3d_reconstruction.magnification_calibration   ? 
_em_3d_reconstruction.nominal_pixel_size          ? 
_em_3d_reconstruction.actual_pixel_size           ? 
_em_3d_reconstruction.num_particles               96290 
_em_3d_reconstruction.euler_angles_details        ? 
_em_3d_reconstruction.num_class_averages          ? 
_em_3d_reconstruction.refinement_type             ? 
_em_3d_reconstruction.image_processing_id         1 
_em_3d_reconstruction.symmetry_type               POINT 
# 
_em_buffer.id            1 
_em_buffer.specimen_id   1 
_em_buffer.name          ? 
_em_buffer.details       ? 
_em_buffer.pH            7.4 
# 
loop_
_em_entity_assembly.id 
_em_entity_assembly.parent_id 
_em_entity_assembly.source 
_em_entity_assembly.type 
_em_entity_assembly.name 
_em_entity_assembly.details 
_em_entity_assembly.synonym 
_em_entity_assembly.oligomeric_details 
_em_entity_assembly.entity_id_list 
1 0 'MULTIPLE SOURCES' COMPLEX 'Integrin alpha-v beta-8 complexed with antibody Fab fragment of 130H2' ? ? ? '1, 2, 3, 4' 
2 1 RECOMBINANT        COMPLEX 'Integrin alpha-v beta-8'                                               ? ? ? 1,4          
3 1 RECOMBINANT        COMPLEX 130H2-Fab                                                               ? ? ? 2,3          
# 
_em_imaging.entry_id                        9IND 
_em_imaging.id                              1 
_em_imaging.astigmatism                     ? 
_em_imaging.electron_beam_tilt_params       ? 
_em_imaging.residual_tilt                   ? 
_em_imaging.microscope_model                'FEI TITAN KRIOS' 
_em_imaging.specimen_holder_type            ? 
_em_imaging.specimen_holder_model           ? 
_em_imaging.details                         ? 
_em_imaging.date                            ? 
_em_imaging.accelerating_voltage            300 
_em_imaging.illumination_mode               'FLOOD BEAM' 
_em_imaging.mode                            'BRIGHT FIELD' 
_em_imaging.nominal_cs                      ? 
_em_imaging.nominal_defocus_min             800 
_em_imaging.nominal_defocus_max             2000 
_em_imaging.calibrated_defocus_min          ? 
_em_imaging.calibrated_defocus_max          ? 
_em_imaging.tilt_angle_min                  ? 
_em_imaging.tilt_angle_max                  ? 
_em_imaging.nominal_magnification           ? 
_em_imaging.calibrated_magnification        ? 
_em_imaging.electron_source                 'FIELD EMISSION GUN' 
_em_imaging.citation_id                     ? 
_em_imaging.temperature                     ? 
_em_imaging.detector_distance               ? 
_em_imaging.recording_temperature_minimum   ? 
_em_imaging.recording_temperature_maximum   ? 
_em_imaging.alignment_procedure             ? 
_em_imaging.c2_aperture_diameter            ? 
_em_imaging.specimen_id                     1 
_em_imaging.cryogen                         ? 
# 
_em_vitrification.entry_id              9IND 
_em_vitrification.id                    1 
_em_vitrification.specimen_id           1 
_em_vitrification.cryogen_name          ETHANE 
_em_vitrification.humidity              ? 
_em_vitrification.temp                  ? 
_em_vitrification.chamber_temperature   ? 
_em_vitrification.instrument            ? 
_em_vitrification.method                ? 
_em_vitrification.time_resolved_state   ? 
_em_vitrification.citation_id           ? 
_em_vitrification.details               ? 
# 
_em_experiment.entry_id                9IND 
_em_experiment.id                      1 
_em_experiment.reconstruction_method   'SINGLE PARTICLE' 
_em_experiment.aggregation_state       PARTICLE 
_em_experiment.entity_assembly_id      1 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1 1 Y 1 B VAL 399 ? D VAL 330 
2 1 Y 1 B THR 400 ? D THR 331 
3 1 Y 1 B GLY 401 ? D GLY 332 
4 1 Y 1 B GLY 402 ? D GLY 333 
5 1 Y 1 B LYS 403 ? D LYS 334 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
BMA C1   C N R 74  
BMA C2   C N S 75  
BMA C3   C N S 76  
BMA C4   C N S 77  
BMA C5   C N R 78  
BMA C6   C N N 79  
BMA O1   O N N 80  
BMA O2   O N N 81  
BMA O3   O N N 82  
BMA O4   O N N 83  
BMA O5   O N N 84  
BMA O6   O N N 85  
BMA H1   H N N 86  
BMA H2   H N N 87  
BMA H3   H N N 88  
BMA H4   H N N 89  
BMA H5   H N N 90  
BMA H61  H N N 91  
BMA H62  H N N 92  
BMA HO1  H N N 93  
BMA HO2  H N N 94  
BMA HO3  H N N 95  
BMA HO4  H N N 96  
BMA HO6  H N N 97  
CYS N    N N N 98  
CYS CA   C N R 99  
CYS C    C N N 100 
CYS O    O N N 101 
CYS CB   C N N 102 
CYS SG   S N N 103 
CYS OXT  O N N 104 
CYS H    H N N 105 
CYS H2   H N N 106 
CYS HA   H N N 107 
CYS HB2  H N N 108 
CYS HB3  H N N 109 
CYS HG   H N N 110 
CYS HXT  H N N 111 
GLN N    N N N 112 
GLN CA   C N S 113 
GLN C    C N N 114 
GLN O    O N N 115 
GLN CB   C N N 116 
GLN CG   C N N 117 
GLN CD   C N N 118 
GLN OE1  O N N 119 
GLN NE2  N N N 120 
GLN OXT  O N N 121 
GLN H    H N N 122 
GLN H2   H N N 123 
GLN HA   H N N 124 
GLN HB2  H N N 125 
GLN HB3  H N N 126 
GLN HG2  H N N 127 
GLN HG3  H N N 128 
GLN HE21 H N N 129 
GLN HE22 H N N 130 
GLN HXT  H N N 131 
GLU N    N N N 132 
GLU CA   C N S 133 
GLU C    C N N 134 
GLU O    O N N 135 
GLU CB   C N N 136 
GLU CG   C N N 137 
GLU CD   C N N 138 
GLU OE1  O N N 139 
GLU OE2  O N N 140 
GLU OXT  O N N 141 
GLU H    H N N 142 
GLU H2   H N N 143 
GLU HA   H N N 144 
GLU HB2  H N N 145 
GLU HB3  H N N 146 
GLU HG2  H N N 147 
GLU HG3  H N N 148 
GLU HE2  H N N 149 
GLU HXT  H N N 150 
GLY N    N N N 151 
GLY CA   C N N 152 
GLY C    C N N 153 
GLY O    O N N 154 
GLY OXT  O N N 155 
GLY H    H N N 156 
GLY H2   H N N 157 
GLY HA2  H N N 158 
GLY HA3  H N N 159 
GLY HXT  H N N 160 
HIS N    N N N 161 
HIS CA   C N S 162 
HIS C    C N N 163 
HIS O    O N N 164 
HIS CB   C N N 165 
HIS CG   C Y N 166 
HIS ND1  N Y N 167 
HIS CD2  C Y N 168 
HIS CE1  C Y N 169 
HIS NE2  N Y N 170 
HIS OXT  O N N 171 
HIS H    H N N 172 
HIS H2   H N N 173 
HIS HA   H N N 174 
HIS HB2  H N N 175 
HIS HB3  H N N 176 
HIS HD1  H N N 177 
HIS HD2  H N N 178 
HIS HE1  H N N 179 
HIS HE2  H N N 180 
HIS HXT  H N N 181 
ILE N    N N N 182 
ILE CA   C N S 183 
ILE C    C N N 184 
ILE O    O N N 185 
ILE CB   C N S 186 
ILE CG1  C N N 187 
ILE CG2  C N N 188 
ILE CD1  C N N 189 
ILE OXT  O N N 190 
ILE H    H N N 191 
ILE H2   H N N 192 
ILE HA   H N N 193 
ILE HB   H N N 194 
ILE HG12 H N N 195 
ILE HG13 H N N 196 
ILE HG21 H N N 197 
ILE HG22 H N N 198 
ILE HG23 H N N 199 
ILE HD11 H N N 200 
ILE HD12 H N N 201 
ILE HD13 H N N 202 
ILE HXT  H N N 203 
LEU N    N N N 204 
LEU CA   C N S 205 
LEU C    C N N 206 
LEU O    O N N 207 
LEU CB   C N N 208 
LEU CG   C N N 209 
LEU CD1  C N N 210 
LEU CD2  C N N 211 
LEU OXT  O N N 212 
LEU H    H N N 213 
LEU H2   H N N 214 
LEU HA   H N N 215 
LEU HB2  H N N 216 
LEU HB3  H N N 217 
LEU HG   H N N 218 
LEU HD11 H N N 219 
LEU HD12 H N N 220 
LEU HD13 H N N 221 
LEU HD21 H N N 222 
LEU HD22 H N N 223 
LEU HD23 H N N 224 
LEU HXT  H N N 225 
LYS N    N N N 226 
LYS CA   C N S 227 
LYS C    C N N 228 
LYS O    O N N 229 
LYS CB   C N N 230 
LYS CG   C N N 231 
LYS CD   C N N 232 
LYS CE   C N N 233 
LYS NZ   N N N 234 
LYS OXT  O N N 235 
LYS H    H N N 236 
LYS H2   H N N 237 
LYS HA   H N N 238 
LYS HB2  H N N 239 
LYS HB3  H N N 240 
LYS HG2  H N N 241 
LYS HG3  H N N 242 
LYS HD2  H N N 243 
LYS HD3  H N N 244 
LYS HE2  H N N 245 
LYS HE3  H N N 246 
LYS HZ1  H N N 247 
LYS HZ2  H N N 248 
LYS HZ3  H N N 249 
LYS HXT  H N N 250 
MAN C1   C N S 251 
MAN C2   C N S 252 
MAN C3   C N S 253 
MAN C4   C N S 254 
MAN C5   C N R 255 
MAN C6   C N N 256 
MAN O1   O N N 257 
MAN O2   O N N 258 
MAN O3   O N N 259 
MAN O4   O N N 260 
MAN O5   O N N 261 
MAN O6   O N N 262 
MAN H1   H N N 263 
MAN H2   H N N 264 
MAN H3   H N N 265 
MAN H4   H N N 266 
MAN H5   H N N 267 
MAN H61  H N N 268 
MAN H62  H N N 269 
MAN HO1  H N N 270 
MAN HO2  H N N 271 
MAN HO3  H N N 272 
MAN HO4  H N N 273 
MAN HO6  H N N 274 
MET N    N N N 275 
MET CA   C N S 276 
MET C    C N N 277 
MET O    O N N 278 
MET CB   C N N 279 
MET CG   C N N 280 
MET SD   S N N 281 
MET CE   C N N 282 
MET OXT  O N N 283 
MET H    H N N 284 
MET H2   H N N 285 
MET HA   H N N 286 
MET HB2  H N N 287 
MET HB3  H N N 288 
MET HG2  H N N 289 
MET HG3  H N N 290 
MET HE1  H N N 291 
MET HE2  H N N 292 
MET HE3  H N N 293 
MET HXT  H N N 294 
NAG C1   C N R 295 
NAG C2   C N R 296 
NAG C3   C N R 297 
NAG C4   C N S 298 
NAG C5   C N R 299 
NAG C6   C N N 300 
NAG C7   C N N 301 
NAG C8   C N N 302 
NAG N2   N N N 303 
NAG O1   O N N 304 
NAG O3   O N N 305 
NAG O4   O N N 306 
NAG O5   O N N 307 
NAG O6   O N N 308 
NAG O7   O N N 309 
NAG H1   H N N 310 
NAG H2   H N N 311 
NAG H3   H N N 312 
NAG H4   H N N 313 
NAG H5   H N N 314 
NAG H61  H N N 315 
NAG H62  H N N 316 
NAG H81  H N N 317 
NAG H82  H N N 318 
NAG H83  H N N 319 
NAG HN2  H N N 320 
NAG HO1  H N N 321 
NAG HO3  H N N 322 
NAG HO4  H N N 323 
NAG HO6  H N N 324 
PHE N    N N N 325 
PHE CA   C N S 326 
PHE C    C N N 327 
PHE O    O N N 328 
PHE CB   C N N 329 
PHE CG   C Y N 330 
PHE CD1  C Y N 331 
PHE CD2  C Y N 332 
PHE CE1  C Y N 333 
PHE CE2  C Y N 334 
PHE CZ   C Y N 335 
PHE OXT  O N N 336 
PHE H    H N N 337 
PHE H2   H N N 338 
PHE HA   H N N 339 
PHE HB2  H N N 340 
PHE HB3  H N N 341 
PHE HD1  H N N 342 
PHE HD2  H N N 343 
PHE HE1  H N N 344 
PHE HE2  H N N 345 
PHE HZ   H N N 346 
PHE HXT  H N N 347 
PRO N    N N N 348 
PRO CA   C N S 349 
PRO C    C N N 350 
PRO O    O N N 351 
PRO CB   C N N 352 
PRO CG   C N N 353 
PRO CD   C N N 354 
PRO OXT  O N N 355 
PRO H    H N N 356 
PRO HA   H N N 357 
PRO HB2  H N N 358 
PRO HB3  H N N 359 
PRO HG2  H N N 360 
PRO HG3  H N N 361 
PRO HD2  H N N 362 
PRO HD3  H N N 363 
PRO HXT  H N N 364 
SER N    N N N 365 
SER CA   C N S 366 
SER C    C N N 367 
SER O    O N N 368 
SER CB   C N N 369 
SER OG   O N N 370 
SER OXT  O N N 371 
SER H    H N N 372 
SER H2   H N N 373 
SER HA   H N N 374 
SER HB2  H N N 375 
SER HB3  H N N 376 
SER HG   H N N 377 
SER HXT  H N N 378 
THR N    N N N 379 
THR CA   C N S 380 
THR C    C N N 381 
THR O    O N N 382 
THR CB   C N R 383 
THR OG1  O N N 384 
THR CG2  C N N 385 
THR OXT  O N N 386 
THR H    H N N 387 
THR H2   H N N 388 
THR HA   H N N 389 
THR HB   H N N 390 
THR HG1  H N N 391 
THR HG21 H N N 392 
THR HG22 H N N 393 
THR HG23 H N N 394 
THR HXT  H N N 395 
TRP N    N N N 396 
TRP CA   C N S 397 
TRP C    C N N 398 
TRP O    O N N 399 
TRP CB   C N N 400 
TRP CG   C Y N 401 
TRP CD1  C Y N 402 
TRP CD2  C Y N 403 
TRP NE1  N Y N 404 
TRP CE2  C Y N 405 
TRP CE3  C Y N 406 
TRP CZ2  C Y N 407 
TRP CZ3  C Y N 408 
TRP CH2  C Y N 409 
TRP OXT  O N N 410 
TRP H    H N N 411 
TRP H2   H N N 412 
TRP HA   H N N 413 
TRP HB2  H N N 414 
TRP HB3  H N N 415 
TRP HD1  H N N 416 
TRP HE1  H N N 417 
TRP HE3  H N N 418 
TRP HZ2  H N N 419 
TRP HZ3  H N N 420 
TRP HH2  H N N 421 
TRP HXT  H N N 422 
TYR N    N N N 423 
TYR CA   C N S 424 
TYR C    C N N 425 
TYR O    O N N 426 
TYR CB   C N N 427 
TYR CG   C Y N 428 
TYR CD1  C Y N 429 
TYR CD2  C Y N 430 
TYR CE1  C Y N 431 
TYR CE2  C Y N 432 
TYR CZ   C Y N 433 
TYR OH   O N N 434 
TYR OXT  O N N 435 
TYR H    H N N 436 
TYR H2   H N N 437 
TYR HA   H N N 438 
TYR HB2  H N N 439 
TYR HB3  H N N 440 
TYR HD1  H N N 441 
TYR HD2  H N N 442 
TYR HE1  H N N 443 
TYR HE2  H N N 444 
TYR HH   H N N 445 
TYR HXT  H N N 446 
VAL N    N N N 447 
VAL CA   C N S 448 
VAL C    C N N 449 
VAL O    O N N 450 
VAL CB   C N N 451 
VAL CG1  C N N 452 
VAL CG2  C N N 453 
VAL OXT  O N N 454 
VAL H    H N N 455 
VAL H2   H N N 456 
VAL HA   H N N 457 
VAL HB   H N N 458 
VAL HG11 H N N 459 
VAL HG12 H N N 460 
VAL HG13 H N N 461 
VAL HG21 H N N 462 
VAL HG22 H N N 463 
VAL HG23 H N N 464 
VAL HXT  H N N 465 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
BMA C1  C2   sing N N 70  
BMA C1  O1   sing N N 71  
BMA C1  O5   sing N N 72  
BMA C1  H1   sing N N 73  
BMA C2  C3   sing N N 74  
BMA C2  O2   sing N N 75  
BMA C2  H2   sing N N 76  
BMA C3  C4   sing N N 77  
BMA C3  O3   sing N N 78  
BMA C3  H3   sing N N 79  
BMA C4  C5   sing N N 80  
BMA C4  O4   sing N N 81  
BMA C4  H4   sing N N 82  
BMA C5  C6   sing N N 83  
BMA C5  O5   sing N N 84  
BMA C5  H5   sing N N 85  
BMA C6  O6   sing N N 86  
BMA C6  H61  sing N N 87  
BMA C6  H62  sing N N 88  
BMA O1  HO1  sing N N 89  
BMA O2  HO2  sing N N 90  
BMA O3  HO3  sing N N 91  
BMA O4  HO4  sing N N 92  
BMA O6  HO6  sing N N 93  
CYS N   CA   sing N N 94  
CYS N   H    sing N N 95  
CYS N   H2   sing N N 96  
CYS CA  C    sing N N 97  
CYS CA  CB   sing N N 98  
CYS CA  HA   sing N N 99  
CYS C   O    doub N N 100 
CYS C   OXT  sing N N 101 
CYS CB  SG   sing N N 102 
CYS CB  HB2  sing N N 103 
CYS CB  HB3  sing N N 104 
CYS SG  HG   sing N N 105 
CYS OXT HXT  sing N N 106 
GLN N   CA   sing N N 107 
GLN N   H    sing N N 108 
GLN N   H2   sing N N 109 
GLN CA  C    sing N N 110 
GLN CA  CB   sing N N 111 
GLN CA  HA   sing N N 112 
GLN C   O    doub N N 113 
GLN C   OXT  sing N N 114 
GLN CB  CG   sing N N 115 
GLN CB  HB2  sing N N 116 
GLN CB  HB3  sing N N 117 
GLN CG  CD   sing N N 118 
GLN CG  HG2  sing N N 119 
GLN CG  HG3  sing N N 120 
GLN CD  OE1  doub N N 121 
GLN CD  NE2  sing N N 122 
GLN NE2 HE21 sing N N 123 
GLN NE2 HE22 sing N N 124 
GLN OXT HXT  sing N N 125 
GLU N   CA   sing N N 126 
GLU N   H    sing N N 127 
GLU N   H2   sing N N 128 
GLU CA  C    sing N N 129 
GLU CA  CB   sing N N 130 
GLU CA  HA   sing N N 131 
GLU C   O    doub N N 132 
GLU C   OXT  sing N N 133 
GLU CB  CG   sing N N 134 
GLU CB  HB2  sing N N 135 
GLU CB  HB3  sing N N 136 
GLU CG  CD   sing N N 137 
GLU CG  HG2  sing N N 138 
GLU CG  HG3  sing N N 139 
GLU CD  OE1  doub N N 140 
GLU CD  OE2  sing N N 141 
GLU OE2 HE2  sing N N 142 
GLU OXT HXT  sing N N 143 
GLY N   CA   sing N N 144 
GLY N   H    sing N N 145 
GLY N   H2   sing N N 146 
GLY CA  C    sing N N 147 
GLY CA  HA2  sing N N 148 
GLY CA  HA3  sing N N 149 
GLY C   O    doub N N 150 
GLY C   OXT  sing N N 151 
GLY OXT HXT  sing N N 152 
HIS N   CA   sing N N 153 
HIS N   H    sing N N 154 
HIS N   H2   sing N N 155 
HIS CA  C    sing N N 156 
HIS CA  CB   sing N N 157 
HIS CA  HA   sing N N 158 
HIS C   O    doub N N 159 
HIS C   OXT  sing N N 160 
HIS CB  CG   sing N N 161 
HIS CB  HB2  sing N N 162 
HIS CB  HB3  sing N N 163 
HIS CG  ND1  sing Y N 164 
HIS CG  CD2  doub Y N 165 
HIS ND1 CE1  doub Y N 166 
HIS ND1 HD1  sing N N 167 
HIS CD2 NE2  sing Y N 168 
HIS CD2 HD2  sing N N 169 
HIS CE1 NE2  sing Y N 170 
HIS CE1 HE1  sing N N 171 
HIS NE2 HE2  sing N N 172 
HIS OXT HXT  sing N N 173 
ILE N   CA   sing N N 174 
ILE N   H    sing N N 175 
ILE N   H2   sing N N 176 
ILE CA  C    sing N N 177 
ILE CA  CB   sing N N 178 
ILE CA  HA   sing N N 179 
ILE C   O    doub N N 180 
ILE C   OXT  sing N N 181 
ILE CB  CG1  sing N N 182 
ILE CB  CG2  sing N N 183 
ILE CB  HB   sing N N 184 
ILE CG1 CD1  sing N N 185 
ILE CG1 HG12 sing N N 186 
ILE CG1 HG13 sing N N 187 
ILE CG2 HG21 sing N N 188 
ILE CG2 HG22 sing N N 189 
ILE CG2 HG23 sing N N 190 
ILE CD1 HD11 sing N N 191 
ILE CD1 HD12 sing N N 192 
ILE CD1 HD13 sing N N 193 
ILE OXT HXT  sing N N 194 
LEU N   CA   sing N N 195 
LEU N   H    sing N N 196 
LEU N   H2   sing N N 197 
LEU CA  C    sing N N 198 
LEU CA  CB   sing N N 199 
LEU CA  HA   sing N N 200 
LEU C   O    doub N N 201 
LEU C   OXT  sing N N 202 
LEU CB  CG   sing N N 203 
LEU CB  HB2  sing N N 204 
LEU CB  HB3  sing N N 205 
LEU CG  CD1  sing N N 206 
LEU CG  CD2  sing N N 207 
LEU CG  HG   sing N N 208 
LEU CD1 HD11 sing N N 209 
LEU CD1 HD12 sing N N 210 
LEU CD1 HD13 sing N N 211 
LEU CD2 HD21 sing N N 212 
LEU CD2 HD22 sing N N 213 
LEU CD2 HD23 sing N N 214 
LEU OXT HXT  sing N N 215 
LYS N   CA   sing N N 216 
LYS N   H    sing N N 217 
LYS N   H2   sing N N 218 
LYS CA  C    sing N N 219 
LYS CA  CB   sing N N 220 
LYS CA  HA   sing N N 221 
LYS C   O    doub N N 222 
LYS C   OXT  sing N N 223 
LYS CB  CG   sing N N 224 
LYS CB  HB2  sing N N 225 
LYS CB  HB3  sing N N 226 
LYS CG  CD   sing N N 227 
LYS CG  HG2  sing N N 228 
LYS CG  HG3  sing N N 229 
LYS CD  CE   sing N N 230 
LYS CD  HD2  sing N N 231 
LYS CD  HD3  sing N N 232 
LYS CE  NZ   sing N N 233 
LYS CE  HE2  sing N N 234 
LYS CE  HE3  sing N N 235 
LYS NZ  HZ1  sing N N 236 
LYS NZ  HZ2  sing N N 237 
LYS NZ  HZ3  sing N N 238 
LYS OXT HXT  sing N N 239 
MAN C1  C2   sing N N 240 
MAN C1  O1   sing N N 241 
MAN C1  O5   sing N N 242 
MAN C1  H1   sing N N 243 
MAN C2  C3   sing N N 244 
MAN C2  O2   sing N N 245 
MAN C2  H2   sing N N 246 
MAN C3  C4   sing N N 247 
MAN C3  O3   sing N N 248 
MAN C3  H3   sing N N 249 
MAN C4  C5   sing N N 250 
MAN C4  O4   sing N N 251 
MAN C4  H4   sing N N 252 
MAN C5  C6   sing N N 253 
MAN C5  O5   sing N N 254 
MAN C5  H5   sing N N 255 
MAN C6  O6   sing N N 256 
MAN C6  H61  sing N N 257 
MAN C6  H62  sing N N 258 
MAN O1  HO1  sing N N 259 
MAN O2  HO2  sing N N 260 
MAN O3  HO3  sing N N 261 
MAN O4  HO4  sing N N 262 
MAN O6  HO6  sing N N 263 
MET N   CA   sing N N 264 
MET N   H    sing N N 265 
MET N   H2   sing N N 266 
MET CA  C    sing N N 267 
MET CA  CB   sing N N 268 
MET CA  HA   sing N N 269 
MET C   O    doub N N 270 
MET C   OXT  sing N N 271 
MET CB  CG   sing N N 272 
MET CB  HB2  sing N N 273 
MET CB  HB3  sing N N 274 
MET CG  SD   sing N N 275 
MET CG  HG2  sing N N 276 
MET CG  HG3  sing N N 277 
MET SD  CE   sing N N 278 
MET CE  HE1  sing N N 279 
MET CE  HE2  sing N N 280 
MET CE  HE3  sing N N 281 
MET OXT HXT  sing N N 282 
NAG C1  C2   sing N N 283 
NAG C1  O1   sing N N 284 
NAG C1  O5   sing N N 285 
NAG C1  H1   sing N N 286 
NAG C2  C3   sing N N 287 
NAG C2  N2   sing N N 288 
NAG C2  H2   sing N N 289 
NAG C3  C4   sing N N 290 
NAG C3  O3   sing N N 291 
NAG C3  H3   sing N N 292 
NAG C4  C5   sing N N 293 
NAG C4  O4   sing N N 294 
NAG C4  H4   sing N N 295 
NAG C5  C6   sing N N 296 
NAG C5  O5   sing N N 297 
NAG C5  H5   sing N N 298 
NAG C6  O6   sing N N 299 
NAG C6  H61  sing N N 300 
NAG C6  H62  sing N N 301 
NAG C7  C8   sing N N 302 
NAG C7  N2   sing N N 303 
NAG C7  O7   doub N N 304 
NAG C8  H81  sing N N 305 
NAG C8  H82  sing N N 306 
NAG C8  H83  sing N N 307 
NAG N2  HN2  sing N N 308 
NAG O1  HO1  sing N N 309 
NAG O3  HO3  sing N N 310 
NAG O4  HO4  sing N N 311 
NAG O6  HO6  sing N N 312 
PHE N   CA   sing N N 313 
PHE N   H    sing N N 314 
PHE N   H2   sing N N 315 
PHE CA  C    sing N N 316 
PHE CA  CB   sing N N 317 
PHE CA  HA   sing N N 318 
PHE C   O    doub N N 319 
PHE C   OXT  sing N N 320 
PHE CB  CG   sing N N 321 
PHE CB  HB2  sing N N 322 
PHE CB  HB3  sing N N 323 
PHE CG  CD1  doub Y N 324 
PHE CG  CD2  sing Y N 325 
PHE CD1 CE1  sing Y N 326 
PHE CD1 HD1  sing N N 327 
PHE CD2 CE2  doub Y N 328 
PHE CD2 HD2  sing N N 329 
PHE CE1 CZ   doub Y N 330 
PHE CE1 HE1  sing N N 331 
PHE CE2 CZ   sing Y N 332 
PHE CE2 HE2  sing N N 333 
PHE CZ  HZ   sing N N 334 
PHE OXT HXT  sing N N 335 
PRO N   CA   sing N N 336 
PRO N   CD   sing N N 337 
PRO N   H    sing N N 338 
PRO CA  C    sing N N 339 
PRO CA  CB   sing N N 340 
PRO CA  HA   sing N N 341 
PRO C   O    doub N N 342 
PRO C   OXT  sing N N 343 
PRO CB  CG   sing N N 344 
PRO CB  HB2  sing N N 345 
PRO CB  HB3  sing N N 346 
PRO CG  CD   sing N N 347 
PRO CG  HG2  sing N N 348 
PRO CG  HG3  sing N N 349 
PRO CD  HD2  sing N N 350 
PRO CD  HD3  sing N N 351 
PRO OXT HXT  sing N N 352 
SER N   CA   sing N N 353 
SER N   H    sing N N 354 
SER N   H2   sing N N 355 
SER CA  C    sing N N 356 
SER CA  CB   sing N N 357 
SER CA  HA   sing N N 358 
SER C   O    doub N N 359 
SER C   OXT  sing N N 360 
SER CB  OG   sing N N 361 
SER CB  HB2  sing N N 362 
SER CB  HB3  sing N N 363 
SER OG  HG   sing N N 364 
SER OXT HXT  sing N N 365 
THR N   CA   sing N N 366 
THR N   H    sing N N 367 
THR N   H2   sing N N 368 
THR CA  C    sing N N 369 
THR CA  CB   sing N N 370 
THR CA  HA   sing N N 371 
THR C   O    doub N N 372 
THR C   OXT  sing N N 373 
THR CB  OG1  sing N N 374 
THR CB  CG2  sing N N 375 
THR CB  HB   sing N N 376 
THR OG1 HG1  sing N N 377 
THR CG2 HG21 sing N N 378 
THR CG2 HG22 sing N N 379 
THR CG2 HG23 sing N N 380 
THR OXT HXT  sing N N 381 
TRP N   CA   sing N N 382 
TRP N   H    sing N N 383 
TRP N   H2   sing N N 384 
TRP CA  C    sing N N 385 
TRP CA  CB   sing N N 386 
TRP CA  HA   sing N N 387 
TRP C   O    doub N N 388 
TRP C   OXT  sing N N 389 
TRP CB  CG   sing N N 390 
TRP CB  HB2  sing N N 391 
TRP CB  HB3  sing N N 392 
TRP CG  CD1  doub Y N 393 
TRP CG  CD2  sing Y N 394 
TRP CD1 NE1  sing Y N 395 
TRP CD1 HD1  sing N N 396 
TRP CD2 CE2  doub Y N 397 
TRP CD2 CE3  sing Y N 398 
TRP NE1 CE2  sing Y N 399 
TRP NE1 HE1  sing N N 400 
TRP CE2 CZ2  sing Y N 401 
TRP CE3 CZ3  doub Y N 402 
TRP CE3 HE3  sing N N 403 
TRP CZ2 CH2  doub Y N 404 
TRP CZ2 HZ2  sing N N 405 
TRP CZ3 CH2  sing Y N 406 
TRP CZ3 HZ3  sing N N 407 
TRP CH2 HH2  sing N N 408 
TRP OXT HXT  sing N N 409 
TYR N   CA   sing N N 410 
TYR N   H    sing N N 411 
TYR N   H2   sing N N 412 
TYR CA  C    sing N N 413 
TYR CA  CB   sing N N 414 
TYR CA  HA   sing N N 415 
TYR C   O    doub N N 416 
TYR C   OXT  sing N N 417 
TYR CB  CG   sing N N 418 
TYR CB  HB2  sing N N 419 
TYR CB  HB3  sing N N 420 
TYR CG  CD1  doub Y N 421 
TYR CG  CD2  sing Y N 422 
TYR CD1 CE1  sing Y N 423 
TYR CD1 HD1  sing N N 424 
TYR CD2 CE2  doub Y N 425 
TYR CD2 HD2  sing N N 426 
TYR CE1 CZ   doub Y N 427 
TYR CE1 HE1  sing N N 428 
TYR CE2 CZ   sing Y N 429 
TYR CE2 HE2  sing N N 430 
TYR CZ  OH   sing N N 431 
TYR OH  HH   sing N N 432 
TYR OXT HXT  sing N N 433 
VAL N   CA   sing N N 434 
VAL N   H    sing N N 435 
VAL N   H2   sing N N 436 
VAL CA  C    sing N N 437 
VAL CA  CB   sing N N 438 
VAL CA  HA   sing N N 439 
VAL C   O    doub N N 440 
VAL C   OXT  sing N N 441 
VAL CB  CG1  sing N N 442 
VAL CB  CG2  sing N N 443 
VAL CB  HB   sing N N 444 
VAL CG1 HG11 sing N N 445 
VAL CG1 HG12 sing N N 446 
VAL CG1 HG13 sing N N 447 
VAL CG2 HG21 sing N N 448 
VAL CG2 HG22 sing N N 449 
VAL CG2 HG23 sing N N 450 
VAL OXT HXT  sing N N 451 
# 
_em_admin.current_status     REL 
_em_admin.deposition_date    2024-07-06 
_em_admin.deposition_site    PDBJ 
_em_admin.entry_id           9IND 
_em_admin.last_update        2025-01-22 
_em_admin.map_release_date   2025-01-22 
_em_admin.title              'Integrin alpha-v beta-8 in complex with the Fab of 130H2' 
# 
_em_ctf_correction.details                  ? 
_em_ctf_correction.em_image_processing_id   1 
_em_ctf_correction.id                       1 
_em_ctf_correction.type                     'PHASE FLIPPING AND AMPLITUDE CORRECTION' 
# 
loop_
_em_entity_assembly_naturalsource.cell 
_em_entity_assembly_naturalsource.cellular_location 
_em_entity_assembly_naturalsource.entity_assembly_id 
_em_entity_assembly_naturalsource.id 
_em_entity_assembly_naturalsource.ncbi_tax_id 
_em_entity_assembly_naturalsource.organism 
_em_entity_assembly_naturalsource.organelle 
_em_entity_assembly_naturalsource.organ 
_em_entity_assembly_naturalsource.strain 
_em_entity_assembly_naturalsource.tissue 
_em_entity_assembly_naturalsource.details 
? ? 2 2 2697049 Homo           ? ? ? ? ? 
? ? 3 3 10090   'Mus musculus' ? ? ? ? ? 
# 
loop_
_em_entity_assembly_recombinant.cell 
_em_entity_assembly_recombinant.entity_assembly_id 
_em_entity_assembly_recombinant.id 
_em_entity_assembly_recombinant.ncbi_tax_id 
_em_entity_assembly_recombinant.organism 
_em_entity_assembly_recombinant.plasmid 
_em_entity_assembly_recombinant.strain 
? 2 2 9606 'Homo sapiens' ? ? 
? 3 3 9606 'Homo sapiens' ? ? 
# 
_em_image_processing.details              ? 
_em_image_processing.id                   1 
_em_image_processing.image_recording_id   1 
# 
_em_image_recording.average_exposure_time               ? 
_em_image_recording.avg_electron_dose_per_subtomogram   ? 
_em_image_recording.avg_electron_dose_per_image         48 
_em_image_recording.details                             ? 
_em_image_recording.detector_mode                       ? 
_em_image_recording.film_or_detector_model              'GATAN K3 (6k x 4k)' 
_em_image_recording.id                                  1 
_em_image_recording.imaging_id                          1 
_em_image_recording.num_diffraction_images              ? 
_em_image_recording.num_grids_imaged                    ? 
_em_image_recording.num_real_images                     ? 
# 
loop_
_em_software.category 
_em_software.details 
_em_software.id 
_em_software.image_processing_id 
_em_software.fitting_id 
_em_software.imaging_id 
_em_software.name 
_em_software.version 
'PARTICLE SELECTION'       ? 1  1 ? ? ? ? 
'IMAGE ACQUISITION'        ? 2  ? ? 1 ? ? 
MASKING                    ? 3  ? ? ? ? ? 
'CTF CORRECTION'           ? 4  1 ? ? ? ? 
'LAYERLINE INDEXING'       ? 5  ? ? ? ? ? 
'DIFFRACTION INDEXING'     ? 6  ? ? ? ? ? 
'MODEL FITTING'            ? 7  ? ? ? ? ? 
'MODEL REFINEMENT'         ? 8  ? ? ? ? ? 
OTHER                      ? 9  ? ? ? ? ? 
'INITIAL EULER ASSIGNMENT' ? 10 1 ? ? ? ? 
'FINAL EULER ASSIGNMENT'   ? 11 1 ? ? ? ? 
CLASSIFICATION             ? 12 1 ? ? ? ? 
RECONSTRUCTION             ? 13 1 ? ? ? ? 
# 
_em_specimen.concentration           ? 
_em_specimen.details                 ? 
_em_specimen.embedding_applied       NO 
_em_specimen.experiment_id           1 
_em_specimen.id                      1 
_em_specimen.shadowing_applied       NO 
_em_specimen.staining_applied        NO 
_em_specimen.vitrification_applied   YES 
# 
_pdbx_audit_support.funding_organization   'Not funded' 
_pdbx_audit_support.country                ? 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
loop_
_pdbx_entity_branch_list.entity_id 
_pdbx_entity_branch_list.comp_id 
_pdbx_entity_branch_list.num 
_pdbx_entity_branch_list.hetero 
5 NAG 1 n 
5 NAG 2 n 
5 BMA 3 n 
5 MAN 4 n 
5 MAN 5 n 
# 
_atom_sites.entry_id                    9IND 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   1.000000 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   1.000000 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   1.000000 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
C 
N 
O 
S 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . PHE A 1 1   ? 136.288 128.458 168.983 1.00 55.84  ? 1   PHE A N   1 
ATOM   2    C CA  . PHE A 1 1   ? 137.305 129.118 169.795 1.00 55.84  ? 1   PHE A CA  1 
ATOM   3    C C   . PHE A 1 1   ? 138.312 128.114 170.353 1.00 55.84  ? 1   PHE A C   1 
ATOM   4    O O   . PHE A 1 1   ? 139.440 128.478 170.683 1.00 55.84  ? 1   PHE A O   1 
ATOM   5    C CB  . PHE A 1 1   ? 136.655 129.918 170.933 1.00 55.84  ? 1   PHE A CB  1 
ATOM   6    C CG  . PHE A 1 1   ? 135.896 129.079 171.931 1.00 55.84  ? 1   PHE A CG  1 
ATOM   7    C CD1 . PHE A 1 1   ? 134.567 128.750 171.711 1.00 55.84  ? 1   PHE A CD1 1 
ATOM   8    C CD2 . PHE A 1 1   ? 136.494 128.667 173.114 1.00 55.84  ? 1   PHE A CD2 1 
ATOM   9    C CE1 . PHE A 1 1   ? 133.862 127.993 172.630 1.00 55.84  ? 1   PHE A CE1 1 
ATOM   10   C CE2 . PHE A 1 1   ? 135.795 127.909 174.033 1.00 55.84  ? 1   PHE A CE2 1 
ATOM   11   C CZ  . PHE A 1 1   ? 134.477 127.574 173.792 1.00 55.84  ? 1   PHE A CZ  1 
ATOM   12   N N   . ASN A 1 2   ? 137.898 126.850 170.451 1.00 53.83  ? 2   ASN A N   1 
ATOM   13   C CA  . ASN A 1 2   ? 138.709 125.807 171.056 1.00 53.83  ? 2   ASN A CA  1 
ATOM   14   C C   . ASN A 1 2   ? 139.483 124.979 170.044 1.00 53.83  ? 2   ASN A C   1 
ATOM   15   O O   . ASN A 1 2   ? 139.931 123.883 170.378 1.00 53.83  ? 2   ASN A O   1 
ATOM   16   C CB  . ASN A 1 2   ? 137.840 124.898 171.921 1.00 53.83  ? 2   ASN A CB  1 
ATOM   17   C CG  . ASN A 1 2   ? 136.660 124.337 171.178 1.00 53.83  ? 2   ASN A CG  1 
ATOM   18   O OD1 . ASN A 1 2   ? 136.460 124.621 170.007 1.00 53.83  ? 2   ASN A OD1 1 
ATOM   19   N ND2 . ASN A 1 2   ? 135.875 123.516 171.856 1.00 53.83  ? 2   ASN A ND2 1 
ATOM   20   N N   . LEU A 1 3   ? 139.638 125.458 168.818 1.00 54.40  ? 3   LEU A N   1 
ATOM   21   C CA  . LEU A 1 3   ? 140.422 124.719 167.843 1.00 54.40  ? 3   LEU A CA  1 
ATOM   22   C C   . LEU A 1 3   ? 141.894 125.074 167.977 1.00 54.40  ? 3   LEU A C   1 
ATOM   23   O O   . LEU A 1 3   ? 142.252 126.194 168.341 1.00 54.40  ? 3   LEU A O   1 
ATOM   24   C CB  . LEU A 1 3   ? 139.928 125.016 166.435 1.00 54.40  ? 3   LEU A CB  1 
ATOM   25   C CG  . LEU A 1 3   ? 138.509 124.526 166.184 1.00 54.40  ? 3   LEU A CG  1 
ATOM   26   C CD1 . LEU A 1 3   ? 138.010 125.004 164.836 1.00 54.40  ? 3   LEU A CD1 1 
ATOM   27   C CD2 . LEU A 1 3   ? 138.485 123.026 166.249 1.00 54.40  ? 3   LEU A CD2 1 
ATOM   28   N N   . ASP A 1 4   ? 142.751 124.107 167.689 1.00 57.17  ? 4   ASP A N   1 
ATOM   29   C CA  . ASP A 1 4   ? 144.186 124.287 167.824 1.00 57.17  ? 4   ASP A CA  1 
ATOM   30   C C   . ASP A 1 4   ? 144.726 124.858 166.525 1.00 57.17  ? 4   ASP A C   1 
ATOM   31   O O   . ASP A 1 4   ? 144.375 124.382 165.443 1.00 57.17  ? 4   ASP A O   1 
ATOM   32   C CB  . ASP A 1 4   ? 144.878 122.967 168.158 1.00 57.17  ? 4   ASP A CB  1 
ATOM   33   C CG  . ASP A 1 4   ? 146.300 123.158 168.663 1.00 57.17  ? 4   ASP A CG  1 
ATOM   34   O OD1 . ASP A 1 4   ? 146.759 124.313 168.774 1.00 57.17  ? 4   ASP A OD1 1 
ATOM   35   O OD2 . ASP A 1 4   ? 146.963 122.141 168.953 1.00 57.17  ? 4   ASP A OD2 1 
ATOM   36   N N   . VAL A 1 5   ? 145.574 125.878 166.636 1.00 57.31  ? 5   VAL A N   1 
ATOM   37   C CA  . VAL A 1 5   ? 146.087 126.594 165.477 1.00 57.31  ? 5   VAL A CA  1 
ATOM   38   C C   . VAL A 1 5   ? 147.596 126.406 165.405 1.00 57.31  ? 5   VAL A C   1 
ATOM   39   O O   . VAL A 1 5   ? 148.176 126.342 164.316 1.00 57.31  ? 5   VAL A O   1 
ATOM   40   C CB  . VAL A 1 5   ? 145.702 128.084 165.557 1.00 57.31  ? 5   VAL A CB  1 
ATOM   41   C CG1 . VAL A 1 5   ? 146.213 128.871 164.360 1.00 57.31  ? 5   VAL A CG1 1 
ATOM   42   C CG2 . VAL A 1 5   ? 144.210 128.229 165.661 1.00 57.31  ? 5   VAL A CG2 1 
ATOM   43   N N   . ASP A 1 6   ? 148.237 126.262 166.562 1.00 60.22  ? 6   ASP A N   1 
ATOM   44   C CA  . ASP A 1 6   ? 149.694 126.277 166.610 1.00 60.22  ? 6   ASP A CA  1 
ATOM   45   C C   . ASP A 1 6   ? 150.322 124.996 166.080 1.00 60.22  ? 6   ASP A C   1 
ATOM   46   O O   . ASP A 1 6   ? 151.488 125.020 165.678 1.00 60.22  ? 6   ASP A O   1 
ATOM   47   C CB  . ASP A 1 6   ? 150.168 126.527 168.038 1.00 60.22  ? 6   ASP A CB  1 
ATOM   48   C CG  . ASP A 1 6   ? 149.862 127.932 168.515 1.00 60.22  ? 6   ASP A CG  1 
ATOM   49   O OD1 . ASP A 1 6   ? 149.821 128.852 167.672 1.00 60.22  ? 6   ASP A OD1 1 
ATOM   50   O OD2 . ASP A 1 6   ? 149.660 128.116 169.734 1.00 60.22  ? 6   ASP A OD2 1 
ATOM   51   N N   . SER A 1 7   ? 149.590 123.884 166.070 1.00 59.52  ? 7   SER A N   1 
ATOM   52   C CA  . SER A 1 7   ? 150.079 122.637 165.476 1.00 59.52  ? 7   SER A CA  1 
ATOM   53   C C   . SER A 1 7   ? 148.915 121.828 164.928 1.00 59.52  ? 7   SER A C   1 
ATOM   54   O O   . SER A 1 7   ? 148.344 120.979 165.621 1.00 59.52  ? 7   SER A O   1 
ATOM   55   C CB  . SER A 1 7   ? 150.867 121.816 166.496 1.00 59.52  ? 7   SER A CB  1 
ATOM   56   O OG  . SER A 1 7   ? 151.294 120.586 165.937 1.00 59.52  ? 7   SER A OG  1 
ATOM   57   N N   . PRO A 1 8   ? 148.513 122.084 163.689 1.00 56.96  ? 8   PRO A N   1 
ATOM   58   C CA  . PRO A 1 8   ? 147.558 121.203 163.018 1.00 56.96  ? 8   PRO A CA  1 
ATOM   59   C C   . PRO A 1 8   ? 148.277 120.198 162.124 1.00 56.96  ? 8   PRO A C   1 
ATOM   60   O O   . PRO A 1 8   ? 149.496 120.232 161.959 1.00 56.96  ? 8   PRO A O   1 
ATOM   61   C CB  . PRO A 1 8   ? 146.722 122.183 162.196 1.00 56.96  ? 8   PRO A CB  1 
ATOM   62   C CG  . PRO A 1 8   ? 147.693 123.232 161.836 1.00 56.96  ? 8   PRO A CG  1 
ATOM   63   C CD  . PRO A 1 8   ? 148.658 123.358 162.965 1.00 56.96  ? 8   PRO A CD  1 
ATOM   64   N N   . ALA A 1 9   ? 147.490 119.301 161.539 1.00 53.18  ? 9   ALA A N   1 
ATOM   65   C CA  . ALA A 1 9   ? 148.020 118.200 160.746 1.00 53.18  ? 9   ALA A CA  1 
ATOM   66   C C   . ALA A 1 9   ? 148.013 118.556 159.264 1.00 53.18  ? 9   ALA A C   1 
ATOM   67   O O   . ALA A 1 9   ? 146.975 118.465 158.607 1.00 53.18  ? 9   ALA A O   1 
ATOM   68   C CB  . ALA A 1 9   ? 147.200 116.938 160.989 1.00 53.18  ? 9   ALA A CB  1 
ATOM   69   N N   . GLU A 1 10  ? 149.170 118.937 158.738 1.00 53.98  ? 10  GLU A N   1 
ATOM   70   C CA  . GLU A 1 10  ? 149.323 119.273 157.330 1.00 53.98  ? 10  GLU A CA  1 
ATOM   71   C C   . GLU A 1 10  ? 149.494 118.012 156.500 1.00 53.98  ? 10  GLU A C   1 
ATOM   72   O O   . GLU A 1 10  ? 150.454 117.262 156.688 1.00 53.98  ? 10  GLU A O   1 
ATOM   73   C CB  . GLU A 1 10  ? 150.534 120.180 157.102 1.00 53.98  ? 10  GLU A CB  1 
ATOM   74   C CG  . GLU A 1 10  ? 150.407 121.574 157.652 1.00 53.98  ? 10  GLU A CG  1 
ATOM   75   C CD  . GLU A 1 10  ? 151.634 122.419 157.396 1.00 53.98  ? 10  GLU A CD  1 
ATOM   76   O OE1 . GLU A 1 10  ? 152.648 121.869 156.919 1.00 53.98  ? 10  GLU A OE1 1 
ATOM   77   O OE2 . GLU A 1 10  ? 151.586 123.638 157.666 1.00 53.98  ? 10  GLU A OE2 1 
ATOM   78   N N   . TYR A 1 11  ? 148.576 117.791 155.570 1.00 52.11  ? 11  TYR A N   1 
ATOM   79   C CA  . TYR A 1 11  ? 148.665 116.674 154.645 1.00 52.11  ? 11  TYR A CA  1 
ATOM   80   C C   . TYR A 1 11  ? 148.838 117.212 153.240 1.00 52.11  ? 11  TYR A C   1 
ATOM   81   O O   . TYR A 1 11  ? 148.216 118.208 152.880 1.00 52.11  ? 11  TYR A O   1 
ATOM   82   C CB  . TYR A 1 11  ? 147.429 115.801 154.710 1.00 52.11  ? 11  TYR A CB  1 
ATOM   83   C CG  . TYR A 1 11  ? 147.319 114.975 155.962 1.00 52.11  ? 11  TYR A CG  1 
ATOM   84   C CD1 . TYR A 1 11  ? 148.408 114.797 156.807 1.00 52.11  ? 11  TYR A CD1 1 
ATOM   85   C CD2 . TYR A 1 11  ? 146.137 114.352 156.289 1.00 52.11  ? 11  TYR A CD2 1 
ATOM   86   C CE1 . TYR A 1 11  ? 148.308 114.036 157.951 1.00 52.11  ? 11  TYR A CE1 1 
ATOM   87   C CE2 . TYR A 1 11  ? 146.037 113.581 157.417 1.00 52.11  ? 11  TYR A CE2 1 
ATOM   88   C CZ  . TYR A 1 11  ? 147.113 113.429 158.248 1.00 52.11  ? 11  TYR A CZ  1 
ATOM   89   O OH  . TYR A 1 11  ? 146.984 112.659 159.377 1.00 52.11  ? 11  TYR A OH  1 
ATOM   90   N N   . SER A 1 12  ? 149.670 116.550 152.444 1.00 46.32  ? 12  SER A N   1 
ATOM   91   C CA  . SER A 1 12  ? 150.027 117.029 151.119 1.00 46.32  ? 12  SER A CA  1 
ATOM   92   C C   . SER A 1 12  ? 149.704 115.980 150.068 1.00 46.32  ? 12  SER A C   1 
ATOM   93   O O   . SER A 1 12  ? 149.534 114.802 150.377 1.00 46.32  ? 12  SER A O   1 
ATOM   94   C CB  . SER A 1 12  ? 151.505 117.377 151.051 1.00 46.32  ? 12  SER A CB  1 
ATOM   95   O OG  . SER A 1 12  ? 151.814 118.410 151.965 1.00 46.32  ? 12  SER A OG  1 
ATOM   96   N N   . GLY A 1 13  ? 149.632 116.416 148.821 1.00 42.95  ? 13  GLY A N   1 
ATOM   97   C CA  . GLY A 1 13  ? 149.276 115.536 147.741 1.00 42.95  ? 13  GLY A CA  1 
ATOM   98   C C   . GLY A 1 13  ? 150.155 115.728 146.528 1.00 42.95  ? 13  GLY A C   1 
ATOM   99   O O   . GLY A 1 13  ? 151.174 116.420 146.579 1.00 42.95  ? 13  GLY A O   1 
ATOM   100  N N   . PRO A 1 14  ? 149.787 115.093 145.415 1.00 42.57  ? 14  PRO A N   1 
ATOM   101  C CA  . PRO A 1 14  ? 150.517 115.310 144.162 1.00 42.57  ? 14  PRO A CA  1 
ATOM   102  C C   . PRO A 1 14  ? 150.306 116.722 143.653 1.00 42.57  ? 14  PRO A C   1 
ATOM   103  O O   . PRO A 1 14  ? 149.258 117.326 143.886 1.00 42.57  ? 14  PRO A O   1 
ATOM   104  C CB  . PRO A 1 14  ? 149.896 114.285 143.212 1.00 42.57  ? 14  PRO A CB  1 
ATOM   105  C CG  . PRO A 1 14  ? 149.289 113.275 144.095 1.00 42.57  ? 14  PRO A CG  1 
ATOM   106  C CD  . PRO A 1 14  ? 148.799 114.016 145.284 1.00 42.57  ? 14  PRO A CD  1 
ATOM   107  N N   . GLU A 1 15  ? 151.309 117.252 142.964 1.00 43.94  ? 15  GLU A N   1 
ATOM   108  C CA  . GLU A 1 15  ? 151.253 118.642 142.538 1.00 43.94  ? 15  GLU A CA  1 
ATOM   109  C C   . GLU A 1 15  ? 150.280 118.802 141.384 1.00 43.94  ? 15  GLU A C   1 
ATOM   110  O O   . GLU A 1 15  ? 150.311 118.039 140.418 1.00 43.94  ? 15  GLU A O   1 
ATOM   111  C CB  . GLU A 1 15  ? 152.638 119.133 142.138 1.00 43.94  ? 15  GLU A CB  1 
ATOM   112  C CG  . GLU A 1 15  ? 152.753 120.640 141.989 1.00 43.94  ? 15  GLU A CG  1 
ATOM   113  C CD  . GLU A 1 15  ? 152.445 121.139 140.586 1.00 43.94  ? 15  GLU A CD  1 
ATOM   114  O OE1 . GLU A 1 15  ? 152.682 120.384 139.619 1.00 43.94  ? 15  GLU A OE1 1 
ATOM   115  O OE2 . GLU A 1 15  ? 151.963 122.284 140.452 1.00 43.94  ? 15  GLU A OE2 1 
ATOM   116  N N   . GLY A 1 16  ? 149.415 119.801 141.488 1.00 41.80  ? 16  GLY A N   1 
ATOM   117  C CA  . GLY A 1 16  ? 148.438 120.059 140.465 1.00 41.80  ? 16  GLY A CA  1 
ATOM   118  C C   . GLY A 1 16  ? 147.312 119.069 140.413 1.00 41.80  ? 16  GLY A C   1 
ATOM   119  O O   . GLY A 1 16  ? 146.598 119.027 139.410 1.00 41.80  ? 16  GLY A O   1 
ATOM   120  N N   . SER A 1 17  ? 147.119 118.279 141.460 1.00 39.87  ? 17  SER A N   1 
ATOM   121  C CA  . SER A 1 17  ? 146.158 117.190 141.438 1.00 39.87  ? 17  SER A CA  1 
ATOM   122  C C   . SER A 1 17  ? 144.814 117.548 142.043 1.00 39.87  ? 17  SER A C   1 
ATOM   123  O O   . SER A 1 17  ? 143.900 116.722 141.981 1.00 39.87  ? 17  SER A O   1 
ATOM   124  C CB  . SER A 1 17  ? 146.729 115.999 142.186 1.00 39.87  ? 17  SER A CB  1 
ATOM   125  O OG  . SER A 1 17  ? 146.934 116.342 143.538 1.00 39.87  ? 17  SER A OG  1 
ATOM   126  N N   . TYR A 1 18  ? 144.686 118.756 142.603 1.00 40.18  ? 18  TYR A N   1 
ATOM   127  C CA  . TYR A 1 18  ? 143.530 119.225 143.385 1.00 40.18  ? 18  TYR A CA  1 
ATOM   128  C C   . TYR A 1 18  ? 143.286 118.342 144.601 1.00 40.18  ? 18  TYR A C   1 
ATOM   129  O O   . TYR A 1 18  ? 142.176 117.881 144.834 1.00 40.18  ? 18  TYR A O   1 
ATOM   130  C CB  . TYR A 1 18  ? 142.246 119.360 142.556 1.00 40.18  ? 18  TYR A CB  1 
ATOM   131  C CG  . TYR A 1 18  ? 142.241 120.476 141.535 1.00 40.18  ? 18  TYR A CG  1 
ATOM   132  C CD1 . TYR A 1 18  ? 143.309 121.348 141.413 1.00 40.18  ? 18  TYR A CD1 1 
ATOM   133  C CD2 . TYR A 1 18  ? 141.133 120.700 140.753 1.00 40.18  ? 18  TYR A CD2 1 
ATOM   134  C CE1 . TYR A 1 18  ? 143.298 122.352 140.504 1.00 40.18  ? 18  TYR A CE1 1 
ATOM   135  C CE2 . TYR A 1 18  ? 141.108 121.724 139.852 1.00 40.18  ? 18  TYR A CE2 1 
ATOM   136  C CZ  . TYR A 1 18  ? 142.192 122.543 139.730 1.00 40.18  ? 18  TYR A CZ  1 
ATOM   137  O OH  . TYR A 1 18  ? 142.168 123.567 138.820 1.00 40.18  ? 18  TYR A OH  1 
ATOM   138  N N   . PHE A 1 19  ? 144.328 118.116 145.379 1.00 41.41  ? 19  PHE A N   1 
ATOM   139  C CA  . PHE A 1 19  ? 144.245 117.355 146.615 1.00 41.41  ? 19  PHE A CA  1 
ATOM   140  C C   . PHE A 1 19  ? 143.507 118.196 147.640 1.00 41.41  ? 19  PHE A C   1 
ATOM   141  O O   . PHE A 1 19  ? 144.061 119.131 148.212 1.00 41.41  ? 19  PHE A O   1 
ATOM   142  C CB  . PHE A 1 19  ? 145.647 117.012 147.094 1.00 41.41  ? 19  PHE A CB  1 
ATOM   143  C CG  . PHE A 1 19  ? 145.693 116.148 148.315 1.00 41.41  ? 19  PHE A CG  1 
ATOM   144  C CD1 . PHE A 1 19  ? 145.568 114.784 148.206 1.00 41.41  ? 19  PHE A CD1 1 
ATOM   145  C CD2 . PHE A 1 19  ? 145.877 116.700 149.568 1.00 41.41  ? 19  PHE A CD2 1 
ATOM   146  C CE1 . PHE A 1 19  ? 145.637 113.994 149.313 1.00 41.41  ? 19  PHE A CE1 1 
ATOM   147  C CE2 . PHE A 1 19  ? 145.929 115.909 150.681 1.00 41.41  ? 19  PHE A CE2 1 
ATOM   148  C CZ  . PHE A 1 19  ? 145.807 114.561 150.556 1.00 41.41  ? 19  PHE A CZ  1 
ATOM   149  N N   . GLY A 1 20  ? 142.254 117.874 147.887 1.00 39.61  ? 20  GLY A N   1 
ATOM   150  C CA  . GLY A 1 20  ? 141.519 118.624 148.872 1.00 39.61  ? 20  GLY A CA  1 
ATOM   151  C C   . GLY A 1 20  ? 140.288 119.262 148.282 1.00 39.61  ? 20  GLY A C   1 
ATOM   152  O O   . GLY A 1 20  ? 139.683 120.142 148.892 1.00 39.61  ? 20  GLY A O   1 
ATOM   153  N N   . PHE A 1 21  ? 139.911 118.830 147.086 1.00 37.40  ? 21  PHE A N   1 
ATOM   154  C CA  . PHE A 1 21  ? 138.686 119.334 146.495 1.00 37.40  ? 21  PHE A CA  1 
ATOM   155  C C   . PHE A 1 21  ? 137.479 118.789 147.240 1.00 37.40  ? 21  PHE A C   1 
ATOM   156  O O   . PHE A 1 21  ? 136.427 119.433 147.294 1.00 37.40  ? 21  PHE A O   1 
ATOM   157  C CB  . PHE A 1 21  ? 138.637 118.957 145.018 1.00 37.40  ? 21  PHE A CB  1 
ATOM   158  C CG  . PHE A 1 21  ? 137.527 119.606 144.262 1.00 37.40  ? 21  PHE A CG  1 
ATOM   159  C CD1 . PHE A 1 21  ? 137.670 120.879 143.778 1.00 37.40  ? 21  PHE A CD1 1 
ATOM   160  C CD2 . PHE A 1 21  ? 136.343 118.944 144.048 1.00 37.40  ? 21  PHE A CD2 1 
ATOM   161  C CE1 . PHE A 1 21  ? 136.657 121.478 143.088 1.00 37.40  ? 21  PHE A CE1 1 
ATOM   162  C CE2 . PHE A 1 21  ? 135.325 119.538 143.365 1.00 37.40  ? 21  PHE A CE2 1 
ATOM   163  C CZ  . PHE A 1 21  ? 135.481 120.806 142.882 1.00 37.40  ? 21  PHE A CZ  1 
ATOM   164  N N   . ALA A 1 22  ? 137.613 117.608 147.827 1.00 39.18  ? 22  ALA A N   1 
ATOM   165  C CA  . ALA A 1 22  ? 136.597 117.030 148.688 1.00 39.18  ? 22  ALA A CA  1 
ATOM   166  C C   . ALA A 1 22  ? 137.300 116.320 149.830 1.00 39.18  ? 22  ALA A C   1 
ATOM   167  O O   . ALA A 1 22  ? 138.301 115.638 149.614 1.00 39.18  ? 22  ALA A O   1 
ATOM   168  C CB  . ALA A 1 22  ? 135.700 116.056 147.930 1.00 39.18  ? 22  ALA A CB  1 
ATOM   169  N N   . VAL A 1 23  ? 136.799 116.508 151.048 1.00 42.78  ? 23  VAL A N   1 
ATOM   170  C CA  . VAL A 1 23  ? 137.332 115.837 152.225 1.00 42.78  ? 23  VAL A CA  1 
ATOM   171  C C   . VAL A 1 23  ? 136.195 115.164 152.978 1.00 42.78  ? 23  VAL A C   1 
ATOM   172  O O   . VAL A 1 23  ? 135.047 115.617 152.940 1.00 42.78  ? 23  VAL A O   1 
ATOM   173  C CB  . VAL A 1 23  ? 138.103 116.799 153.156 1.00 42.78  ? 23  VAL A CB  1 
ATOM   174  C CG1 . VAL A 1 23  ? 139.354 117.305 152.486 1.00 42.78  ? 23  VAL A CG1 1 
ATOM   175  C CG2 . VAL A 1 23  ? 137.248 117.958 153.546 1.00 42.78  ? 23  VAL A CG2 1 
ATOM   176  N N   . ASP A 1 24  ? 136.516 114.054 153.642 1.00 45.63  ? 24  ASP A N   1 
ATOM   177  C CA  . ASP A 1 24  ? 135.592 113.389 154.552 1.00 45.63  ? 24  ASP A CA  1 
ATOM   178  C C   . ASP A 1 24  ? 136.415 112.559 155.535 1.00 45.63  ? 24  ASP A C   1 
ATOM   179  O O   . ASP A 1 24  ? 137.637 112.460 155.420 1.00 45.63  ? 24  ASP A O   1 
ATOM   180  C CB  . ASP A 1 24  ? 134.577 112.536 153.794 1.00 45.63  ? 24  ASP A CB  1 
ATOM   181  C CG  . ASP A 1 24  ? 133.344 112.257 154.608 1.00 45.63  ? 24  ASP A CG  1 
ATOM   182  O OD1 . ASP A 1 24  ? 133.308 112.679 155.774 1.00 45.63  ? 24  ASP A OD1 1 
ATOM   183  O OD2 . ASP A 1 24  ? 132.409 111.623 154.106 1.00 45.63  ? 24  ASP A OD2 1 
ATOM   184  N N   . PHE A 1 25  ? 135.734 111.986 156.522 1.00 47.98  ? 25  PHE A N   1 
ATOM   185  C CA  . PHE A 1 25  ? 136.320 111.104 157.516 1.00 47.98  ? 25  PHE A CA  1 
ATOM   186  C C   . PHE A 1 25  ? 135.985 109.666 157.169 1.00 47.98  ? 25  PHE A C   1 
ATOM   187  O O   . PHE A 1 25  ? 134.867 109.375 156.745 1.00 47.98  ? 25  PHE A O   1 
ATOM   188  C CB  . PHE A 1 25  ? 135.764 111.404 158.906 1.00 47.98  ? 25  PHE A CB  1 
ATOM   189  C CG  . PHE A 1 25  ? 136.119 112.750 159.428 1.00 47.98  ? 25  PHE A CG  1 
ATOM   190  C CD1 . PHE A 1 25  ? 137.286 112.945 160.120 1.00 47.98  ? 25  PHE A CD1 1 
ATOM   191  C CD2 . PHE A 1 25  ? 135.277 113.823 159.227 1.00 47.98  ? 25  PHE A CD2 1 
ATOM   192  C CE1 . PHE A 1 25  ? 137.616 114.186 160.598 1.00 47.98  ? 25  PHE A CE1 1 
ATOM   193  C CE2 . PHE A 1 25  ? 135.604 115.065 159.705 1.00 47.98  ? 25  PHE A CE2 1 
ATOM   194  C CZ  . PHE A 1 25  ? 136.778 115.245 160.391 1.00 47.98  ? 25  PHE A CZ  1 
ATOM   195  N N   . PHE A 1 26  ? 136.933 108.760 157.372 1.00 48.44  ? 26  PHE A N   1 
ATOM   196  C CA  . PHE A 1 26  ? 136.637 107.332 157.301 1.00 48.44  ? 26  PHE A CA  1 
ATOM   197  C C   . PHE A 1 26  ? 136.983 106.708 158.642 1.00 48.44  ? 26  PHE A C   1 
ATOM   198  O O   . PHE A 1 26  ? 138.154 106.555 158.995 1.00 48.44  ? 26  PHE A O   1 
ATOM   199  C CB  . PHE A 1 26  ? 137.364 106.642 156.158 1.00 48.44  ? 26  PHE A CB  1 
ATOM   200  C CG  . PHE A 1 26  ? 137.002 105.196 156.001 1.00 48.44  ? 26  PHE A CG  1 
ATOM   201  C CD1 . PHE A 1 26  ? 135.702 104.827 155.753 1.00 48.44  ? 26  PHE A CD1 1 
ATOM   202  C CD2 . PHE A 1 26  ? 137.970 104.219 156.028 1.00 48.44  ? 26  PHE A CD2 1 
ATOM   203  C CE1 . PHE A 1 26  ? 135.364 103.515 155.593 1.00 48.44  ? 26  PHE A CE1 1 
ATOM   204  C CE2 . PHE A 1 26  ? 137.634 102.904 155.857 1.00 48.44  ? 26  PHE A CE2 1 
ATOM   205  C CZ  . PHE A 1 26  ? 136.329 102.555 155.641 1.00 48.44  ? 26  PHE A CZ  1 
ATOM   206  N N   . VAL A 1 27  ? 135.940 106.375 159.385 1.00 51.73  ? 27  VAL A N   1 
ATOM   207  C CA  . VAL A 1 27  ? 136.034 105.613 160.617 1.00 51.73  ? 27  VAL A CA  1 
ATOM   208  C C   . VAL A 1 27  ? 135.318 104.301 160.336 1.00 51.73  ? 27  VAL A C   1 
ATOM   209  O O   . VAL A 1 27  ? 134.088 104.296 160.214 1.00 51.73  ? 27  VAL A O   1 
ATOM   210  C CB  . VAL A 1 27  ? 135.396 106.372 161.788 1.00 51.73  ? 27  VAL A CB  1 
ATOM   211  C CG1 . VAL A 1 27  ? 135.519 105.575 163.076 1.00 51.73  ? 27  VAL A CG1 1 
ATOM   212  C CG2 . VAL A 1 27  ? 136.004 107.759 161.917 1.00 51.73  ? 27  VAL A CG2 1 
ATOM   213  N N   . PRO A 1 28  ? 136.029 103.185 160.203 1.00 53.02  ? 28  PRO A N   1 
ATOM   214  C CA  . PRO A 1 28  ? 135.374 101.917 159.888 1.00 53.02  ? 28  PRO A CA  1 
ATOM   215  C C   . PRO A 1 28  ? 134.541 101.397 161.047 1.00 53.02  ? 28  PRO A C   1 
ATOM   216  O O   . PRO A 1 28  ? 134.491 101.971 162.135 1.00 53.02  ? 28  PRO A O   1 
ATOM   217  C CB  . PRO A 1 28  ? 136.543 100.983 159.593 1.00 53.02  ? 28  PRO A CB  1 
ATOM   218  C CG  . PRO A 1 28  ? 137.659 101.864 159.274 1.00 53.02  ? 28  PRO A CG  1 
ATOM   219  C CD  . PRO A 1 28  ? 137.486 103.072 160.098 1.00 53.02  ? 28  PRO A CD  1 
ATOM   220  N N   . SER A 1 29  ? 133.872 100.272 160.798 1.00 56.99  ? 29  SER A N   1 
ATOM   221  C CA  . SER A 1 29  ? 132.993 99.704  161.811 1.00 56.99  ? 29  SER A CA  1 
ATOM   222  C C   . SER A 1 29  ? 133.785 99.052  162.936 1.00 56.99  ? 29  SER A C   1 
ATOM   223  O O   . SER A 1 29  ? 133.654 99.439  164.103 1.00 56.99  ? 29  SER A O   1 
ATOM   224  C CB  . SER A 1 29  ? 132.040 98.699  161.175 1.00 56.99  ? 29  SER A CB  1 
ATOM   225  O OG  . SER A 1 29  ? 131.126 99.348  160.314 1.00 56.99  ? 29  SER A OG  1 
ATOM   226  N N   . ALA A 1 30  ? 134.620 98.072  162.610 1.00 63.42  ? 30  ALA A N   1 
ATOM   227  C CA  . ALA A 1 30  ? 135.311 97.285  163.627 1.00 63.42  ? 30  ALA A CA  1 
ATOM   228  C C   . ALA A 1 30  ? 136.807 97.240  163.337 1.00 63.42  ? 30  ALA A C   1 
ATOM   229  O O   . ALA A 1 30  ? 137.441 96.185  163.365 1.00 63.42  ? 30  ALA A O   1 
ATOM   230  C CB  . ALA A 1 30  ? 134.727 95.876  163.716 1.00 63.42  ? 30  ALA A CB  1 
ATOM   231  N N   . SER A 1 31  ? 137.392 98.402  163.055 1.00 65.92  ? 31  SER A N   1 
ATOM   232  C CA  . SER A 1 31  ? 138.821 98.482  162.795 1.00 65.92  ? 31  SER A CA  1 
ATOM   233  C C   . SER A 1 31  ? 139.581 99.283  163.836 1.00 65.92  ? 31  SER A C   1 
ATOM   234  O O   . SER A 1 31  ? 140.779 99.043  164.018 1.00 65.92  ? 31  SER A O   1 
ATOM   235  C CB  . SER A 1 31  ? 139.082 99.094  161.417 1.00 65.92  ? 31  SER A CB  1 
ATOM   236  O OG  . SER A 1 31  ? 140.471 99.241  161.179 1.00 65.92  ? 31  SER A OG  1 
ATOM   237  N N   . SER A 1 32  ? 138.914 100.234 164.498 1.00 65.57  ? 32  SER A N   1 
ATOM   238  C CA  . SER A 1 32  ? 139.465 101.099 165.547 1.00 65.57  ? 32  SER A CA  1 
ATOM   239  C C   . SER A 1 32  ? 140.659 101.925 165.075 1.00 65.57  ? 32  SER A C   1 
ATOM   240  O O   . SER A 1 32  ? 141.516 102.297 165.879 1.00 65.57  ? 32  SER A O   1 
ATOM   241  C CB  . SER A 1 32  ? 139.841 100.311 166.811 1.00 65.57  ? 32  SER A CB  1 
ATOM   242  O OG  . SER A 1 32  ? 140.972 99.482  166.599 1.00 65.57  ? 32  SER A OG  1 
ATOM   243  N N   . ARG A 1 33  ? 140.741 102.202 163.782 1.00 61.72  ? 33  ARG A N   1 
ATOM   244  C CA  . ARG A 1 33  ? 141.617 103.226 163.241 1.00 61.72  ? 33  ARG A CA  1 
ATOM   245  C C   . ARG A 1 33  ? 140.737 104.296 162.620 1.00 61.72  ? 33  ARG A C   1 
ATOM   246  O O   . ARG A 1 33  ? 139.560 104.055 162.353 1.00 61.72  ? 33  ARG A O   1 
ATOM   247  C CB  . ARG A 1 33  ? 142.573 102.657 162.209 1.00 61.72  ? 33  ARG A CB  1 
ATOM   248  C CG  . ARG A 1 33  ? 143.533 101.662 162.785 1.00 61.72  ? 33  ARG A CG  1 
ATOM   249  C CD  . ARG A 1 33  ? 144.496 102.348 163.714 1.00 61.72  ? 33  ARG A CD  1 
ATOM   250  N NE  . ARG A 1 33  ? 145.292 103.339 163.009 1.00 61.72  ? 33  ARG A NE  1 
ATOM   251  C CZ  . ARG A 1 33  ? 146.425 103.063 162.376 1.00 61.72  ? 33  ARG A CZ  1 
ATOM   252  N NH1 . ARG A 1 33  ? 146.892 101.824 162.364 1.00 61.72  ? 33  ARG A NH1 1 
ATOM   253  N NH2 . ARG A 1 33  ? 147.094 104.025 161.758 1.00 61.72  ? 33  ARG A NH2 1 
ATOM   254  N N   . MET A 1 34  ? 141.279 105.490 162.430 1.00 56.73  ? 34  MET A N   1 
ATOM   255  C CA  . MET A 1 34  ? 140.507 106.576 161.854 1.00 56.73  ? 34  MET A CA  1 
ATOM   256  C C   . MET A 1 34  ? 141.301 107.250 160.754 1.00 56.73  ? 34  MET A C   1 
ATOM   257  O O   . MET A 1 34  ? 142.489 107.531 160.915 1.00 56.73  ? 34  MET A O   1 
ATOM   258  C CB  . MET A 1 34  ? 140.090 107.583 162.920 1.00 56.73  ? 34  MET A CB  1 
ATOM   259  C CG  . MET A 1 34  ? 139.028 107.043 163.870 1.00 56.73  ? 34  MET A CG  1 
ATOM   260  S SD  . MET A 1 34  ? 138.405 108.238 165.052 1.00 56.73  ? 34  MET A SD  1 
ATOM   261  C CE  . MET A 1 34  ? 137.236 107.250 165.975 1.00 56.73  ? 34  MET A CE  1 
ATOM   262  N N   . PHE A 1 35  ? 140.633 107.501 159.634 1.00 50.41  ? 35  PHE A N   1 
ATOM   263  C CA  . PHE A 1 35  ? 141.282 107.988 158.433 1.00 50.41  ? 35  PHE A CA  1 
ATOM   264  C C   . PHE A 1 35  ? 140.550 109.207 157.908 1.00 50.41  ? 35  PHE A C   1 
ATOM   265  O O   . PHE A 1 35  ? 139.335 109.342 158.053 1.00 50.41  ? 35  PHE A O   1 
ATOM   266  C CB  . PHE A 1 35  ? 141.301 106.935 157.329 1.00 50.41  ? 35  PHE A CB  1 
ATOM   267  C CG  . PHE A 1 35  ? 142.053 105.701 157.680 1.00 50.41  ? 35  PHE A CG  1 
ATOM   268  C CD1 . PHE A 1 35  ? 143.423 105.663 157.585 1.00 50.41  ? 35  PHE A CD1 1 
ATOM   269  C CD2 . PHE A 1 35  ? 141.377 104.570 158.087 1.00 50.41  ? 35  PHE A CD2 1 
ATOM   270  C CE1 . PHE A 1 35  ? 144.106 104.530 157.904 1.00 50.41  ? 35  PHE A CE1 1 
ATOM   271  C CE2 . PHE A 1 35  ? 142.052 103.438 158.403 1.00 50.41  ? 35  PHE A CE2 1 
ATOM   272  C CZ  . PHE A 1 35  ? 143.419 103.413 158.312 1.00 50.41  ? 35  PHE A CZ  1 
ATOM   273  N N   . LEU A 1 36  ? 141.314 110.074 157.260 1.00 48.54  ? 36  LEU A N   1 
ATOM   274  C CA  . LEU A 1 36  ? 140.793 111.188 156.495 1.00 48.54  ? 36  LEU A CA  1 
ATOM   275  C C   . LEU A 1 36  ? 140.747 110.800 155.029 1.00 48.54  ? 36  LEU A C   1 
ATOM   276  O O   . LEU A 1 36  ? 141.709 110.262 154.482 1.00 48.54  ? 36  LEU A O   1 
ATOM   277  C CB  . LEU A 1 36  ? 141.672 112.420 156.664 1.00 48.54  ? 36  LEU A CB  1 
ATOM   278  C CG  . LEU A 1 36  ? 141.790 112.890 158.104 1.00 48.54  ? 36  LEU A CG  1 
ATOM   279  C CD1 . LEU A 1 36  ? 142.686 114.076 158.236 1.00 48.54  ? 36  LEU A CD1 1 
ATOM   280  C CD2 . LEU A 1 36  ? 140.452 113.245 158.613 1.00 48.54  ? 36  LEU A CD2 1 
ATOM   281  N N   . LEU A 1 37  ? 139.621 111.077 154.393 1.00 44.84  ? 37  LEU A N   1 
ATOM   282  C CA  . LEU A 1 37  ? 139.444 110.817 152.975 1.00 44.84  ? 37  LEU A CA  1 
ATOM   283  C C   . LEU A 1 37  ? 139.600 112.127 152.232 1.00 44.84  ? 37  LEU A C   1 
ATOM   284  O O   . LEU A 1 37  ? 139.163 113.171 152.716 1.00 44.84  ? 37  LEU A O   1 
ATOM   285  C CB  . LEU A 1 37  ? 138.083 110.216 152.695 1.00 44.84  ? 37  LEU A CB  1 
ATOM   286  C CG  . LEU A 1 37  ? 137.865 108.855 153.296 1.00 44.84  ? 37  LEU A CG  1 
ATOM   287  C CD1 . LEU A 1 37  ? 136.455 108.446 153.010 1.00 44.84  ? 37  LEU A CD1 1 
ATOM   288  C CD2 . LEU A 1 37  ? 138.846 107.874 152.717 1.00 44.84  ? 37  LEU A CD2 1 
ATOM   289  N N   . VAL A 1 38  ? 140.234 112.073 151.070 1.00 41.77  ? 38  VAL A N   1 
ATOM   290  C CA  . VAL A 1 38  ? 140.582 113.247 150.287 1.00 41.77  ? 38  VAL A CA  1 
ATOM   291  C C   . VAL A 1 38  ? 140.435 112.901 148.817 1.00 41.77  ? 38  VAL A C   1 
ATOM   292  O O   . VAL A 1 38  ? 140.909 111.853 148.371 1.00 41.77  ? 38  VAL A O   1 
ATOM   293  C CB  . VAL A 1 38  ? 142.004 113.730 150.589 1.00 41.77  ? 38  VAL A CB  1 
ATOM   294  C CG1 . VAL A 1 38  ? 142.021 114.585 151.809 1.00 41.77  ? 38  VAL A CG1 1 
ATOM   295  C CG2 . VAL A 1 38  ? 142.851 112.535 150.874 1.00 41.77  ? 38  VAL A CG2 1 
ATOM   296  N N   . GLY A 1 39  ? 139.769 113.764 148.073 1.00 38.54  ? 39  GLY A N   1 
ATOM   297  C CA  . GLY A 1 39  ? 139.652 113.582 146.652 1.00 38.54  ? 39  GLY A CA  1 
ATOM   298  C C   . GLY A 1 39  ? 140.637 114.462 145.918 1.00 38.54  ? 39  GLY A C   1 
ATOM   299  O O   . GLY A 1 39  ? 140.792 115.632 146.226 1.00 38.54  ? 39  GLY A O   1 
ATOM   300  N N   . ALA A 1 40  ? 141.320 113.868 144.945 1.00 38.08  ? 40  ALA A N   1 
ATOM   301  C CA  . ALA A 1 40  ? 142.186 114.609 144.033 1.00 38.08  ? 40  ALA A CA  1 
ATOM   302  C C   . ALA A 1 40  ? 141.693 114.307 142.633 1.00 38.08  ? 40  ALA A C   1 
ATOM   303  O O   . ALA A 1 40  ? 142.193 113.393 141.973 1.00 38.08  ? 40  ALA A O   1 
ATOM   304  C CB  . ALA A 1 40  ? 143.654 114.225 144.206 1.00 38.08  ? 40  ALA A CB  1 
ATOM   305  N N   . PRO A 1 41  ? 140.712 115.069 142.138 1.00 36.15  ? 41  PRO A N   1 
ATOM   306  C CA  . PRO A 1 41  ? 139.968 114.652 140.942 1.00 36.15  ? 41  PRO A CA  1 
ATOM   307  C C   . PRO A 1 41  ? 140.737 114.789 139.649 1.00 36.15  ? 41  PRO A C   1 
ATOM   308  O O   . PRO A 1 41  ? 140.243 114.340 138.611 1.00 36.15  ? 41  PRO A O   1 
ATOM   309  C CB  . PRO A 1 41  ? 138.776 115.601 140.937 1.00 36.15  ? 41  PRO A CB  1 
ATOM   310  C CG  . PRO A 1 41  ? 138.744 116.209 142.273 1.00 36.15  ? 41  PRO A CG  1 
ATOM   311  C CD  . PRO A 1 41  ? 140.138 116.283 142.722 1.00 36.15  ? 41  PRO A CD  1 
ATOM   312  N N   . LYS A 1 42  ? 141.906 115.425 139.682 1.00 40.03  ? 42  LYS A N   1 
ATOM   313  C CA  . LYS A 1 42  ? 142.788 115.609 138.539 1.00 40.03  ? 42  LYS A CA  1 
ATOM   314  C C   . LYS A 1 42  ? 144.137 114.942 138.762 1.00 40.03  ? 42  LYS A C   1 
ATOM   315  O O   . LYS A 1 42  ? 145.157 115.419 138.267 1.00 40.03  ? 42  LYS A O   1 
ATOM   316  C CB  . LYS A 1 42  ? 142.990 117.094 138.246 1.00 40.03  ? 42  LYS A CB  1 
ATOM   317  C CG  . LYS A 1 42  ? 141.815 117.779 137.594 1.00 40.03  ? 42  LYS A CG  1 
ATOM   318  C CD  . LYS A 1 42  ? 142.081 119.247 137.467 1.00 40.03  ? 42  LYS A CD  1 
ATOM   319  C CE  . LYS A 1 42  ? 143.222 119.511 136.534 1.00 40.03  ? 42  LYS A CE  1 
ATOM   320  N NZ  . LYS A 1 42  ? 142.869 119.177 135.134 1.00 40.03  ? 42  LYS A NZ  1 
ATOM   321  N N   . ALA A 1 43  ? 144.166 113.847 139.510 1.00 40.81  ? 43  ALA A N   1 
ATOM   322  C CA  . ALA A 1 43  ? 145.410 113.150 139.790 1.00 40.81  ? 43  ALA A CA  1 
ATOM   323  C C   . ALA A 1 43  ? 145.595 112.009 138.805 1.00 40.81  ? 43  ALA A C   1 
ATOM   324  O O   . ALA A 1 43  ? 144.656 111.257 138.537 1.00 40.81  ? 43  ALA A O   1 
ATOM   325  C CB  . ALA A 1 43  ? 145.427 112.620 141.218 1.00 40.81  ? 43  ALA A CB  1 
ATOM   326  N N   . ASN A 1 44  ? 146.806 111.890 138.269 1.00 42.51  ? 44  ASN A N   1 
ATOM   327  C CA  . ASN A 1 44  ? 147.116 110.815 137.342 1.00 42.51  ? 44  ASN A CA  1 
ATOM   328  C C   . ASN A 1 44  ? 147.136 109.478 138.057 1.00 42.51  ? 44  ASN A C   1 
ATOM   329  O O   . ASN A 1 44  ? 147.903 109.274 138.998 1.00 42.51  ? 44  ASN A O   1 
ATOM   330  C CB  . ASN A 1 44  ? 148.459 111.075 136.668 1.00 42.51  ? 44  ASN A CB  1 
ATOM   331  C CG  . ASN A 1 44  ? 148.347 112.040 135.518 1.00 42.51  ? 44  ASN A CG  1 
ATOM   332  O OD1 . ASN A 1 44  ? 147.435 111.932 134.711 1.00 42.51  ? 44  ASN A OD1 1 
ATOM   333  N ND2 . ASN A 1 44  ? 149.258 112.984 135.431 1.00 42.51  ? 44  ASN A ND2 1 
ATOM   334  N N   . THR A 1 45  ? 146.279 108.570 137.612 1.00 42.78  ? 45  THR A N   1 
ATOM   335  C CA  . THR A 1 45  ? 146.232 107.210 138.109 1.00 42.78  ? 45  THR A CA  1 
ATOM   336  C C   . THR A 1 45  ? 147.052 106.322 137.189 1.00 42.78  ? 45  THR A C   1 
ATOM   337  O O   . THR A 1 45  ? 147.559 106.765 136.158 1.00 42.78  ? 45  THR A O   1 
ATOM   338  C CB  . THR A 1 45  ? 144.795 106.693 138.184 1.00 42.78  ? 45  THR A CB  1 
ATOM   339  O OG1 . THR A 1 45  ? 144.210 106.725 136.880 1.00 42.78  ? 45  THR A OG1 1 
ATOM   340  C CG2 . THR A 1 45  ? 143.975 107.556 139.104 1.00 42.78  ? 45  THR A CG2 1 
ATOM   341  N N   . THR A 1 46  ? 147.177 105.057 137.572 1.00 43.56  ? 46  THR A N   1 
ATOM   342  C CA  . THR A 1 46  ? 147.889 104.078 136.765 1.00 43.56  ? 46  THR A CA  1 
ATOM   343  C C   . THR A 1 46  ? 146.978 103.316 135.829 1.00 43.56  ? 46  THR A C   1 
ATOM   344  O O   . THR A 1 46  ? 147.370 102.263 135.325 1.00 43.56  ? 46  THR A O   1 
ATOM   345  C CB  . THR A 1 46  ? 148.643 103.104 137.667 1.00 43.56  ? 46  THR A CB  1 
ATOM   346  O OG1 . THR A 1 46  ? 149.379 102.179 136.860 1.00 43.56  ? 46  THR A OG1 1 
ATOM   347  C CG2 . THR A 1 46  ? 147.683 102.353 138.574 1.00 43.56  ? 46  THR A CG2 1 
ATOM   348  N N   . GLN A 1 47  ? 145.787 103.829 135.580 1.00 42.95  ? 47  GLN A N   1 
ATOM   349  C CA  . GLN A 1 47  ? 144.846 103.165 134.707 1.00 42.95  ? 47  GLN A CA  1 
ATOM   350  C C   . GLN A 1 47  ? 145.323 103.274 133.261 1.00 42.95  ? 47  GLN A C   1 
ATOM   351  O O   . GLN A 1 47  ? 145.895 104.292 132.870 1.00 42.95  ? 47  GLN A O   1 
ATOM   352  C CB  . GLN A 1 47  ? 143.469 103.795 134.875 1.00 42.95  ? 47  GLN A CB  1 
ATOM   353  C CG  . GLN A 1 47  ? 142.942 103.659 136.293 1.00 42.95  ? 47  GLN A CG  1 
ATOM   354  C CD  . GLN A 1 47  ? 141.607 104.317 136.500 1.00 42.95  ? 47  GLN A CD  1 
ATOM   355  O OE1 . GLN A 1 47  ? 141.062 104.939 135.599 1.00 42.95  ? 47  GLN A OE1 1 
ATOM   356  N NE2 . GLN A 1 47  ? 141.071 104.188 137.699 1.00 42.95  ? 47  GLN A NE2 1 
ATOM   357  N N   . PRO A 1 48  ? 145.130 102.226 132.455 1.00 42.55  ? 48  PRO A N   1 
ATOM   358  C CA  . PRO A 1 48  ? 145.741 102.185 131.119 1.00 42.55  ? 48  PRO A CA  1 
ATOM   359  C C   . PRO A 1 48  ? 145.034 103.098 130.127 1.00 42.55  ? 48  PRO A C   1 
ATOM   360  O O   . PRO A 1 48  ? 143.838 102.958 129.870 1.00 42.55  ? 48  PRO A O   1 
ATOM   361  C CB  . PRO A 1 48  ? 145.612 100.713 130.721 1.00 42.55  ? 48  PRO A CB  1 
ATOM   362  C CG  . PRO A 1 48  ? 144.478 100.218 131.499 1.00 42.55  ? 48  PRO A CG  1 
ATOM   363  C CD  . PRO A 1 48  ? 144.496 100.944 132.796 1.00 42.55  ? 48  PRO A CD  1 
ATOM   364  N N   . GLY A 1 49  ? 145.791 104.026 129.555 1.00 43.29  ? 49  GLY A N   1 
ATOM   365  C CA  . GLY A 1 49  ? 145.267 104.918 128.547 1.00 43.29  ? 49  GLY A CA  1 
ATOM   366  C C   . GLY A 1 49  ? 144.448 106.067 129.075 1.00 43.29  ? 49  GLY A C   1 
ATOM   367  O O   . GLY A 1 49  ? 143.682 106.663 128.311 1.00 43.29  ? 49  GLY A O   1 
ATOM   368  N N   . ILE A 1 50  ? 144.588 106.406 130.354 1.00 41.41  ? 50  ILE A N   1 
ATOM   369  C CA  . ILE A 1 50  ? 143.724 107.371 131.021 1.00 41.41  ? 50  ILE A CA  1 
ATOM   370  C C   . ILE A 1 50  ? 144.593 108.432 131.670 1.00 41.41  ? 50  ILE A C   1 
ATOM   371  O O   . ILE A 1 50  ? 145.419 108.120 132.533 1.00 41.41  ? 50  ILE A O   1 
ATOM   372  C CB  . ILE A 1 50  ? 142.821 106.693 132.055 1.00 41.41  ? 50  ILE A CB  1 
ATOM   373  C CG1 . ILE A 1 50  ? 141.795 105.835 131.340 1.00 41.41  ? 50  ILE A CG1 1 
ATOM   374  C CG2 . ILE A 1 50  ? 142.139 107.705 132.917 1.00 41.41  ? 50  ILE A CG2 1 
ATOM   375  C CD1 . ILE A 1 50  ? 141.098 104.914 132.236 1.00 41.41  ? 50  ILE A CD1 1 
ATOM   376  N N   . VAL A 1 51  ? 144.409 109.679 131.253 1.00 42.88  ? 51  VAL A N   1 
ATOM   377  C CA  . VAL A 1 51  ? 145.194 110.809 131.729 1.00 42.88  ? 51  VAL A CA  1 
ATOM   378  C C   . VAL A 1 51  ? 144.346 111.630 132.688 1.00 42.88  ? 51  VAL A C   1 
ATOM   379  O O   . VAL A 1 51  ? 143.273 112.113 132.307 1.00 42.88  ? 51  VAL A O   1 
ATOM   380  C CB  . VAL A 1 51  ? 145.678 111.669 130.555 1.00 42.88  ? 51  VAL A CB  1 
ATOM   381  C CG1 . VAL A 1 51  ? 146.314 112.928 131.064 1.00 42.88  ? 51  VAL A CG1 1 
ATOM   382  C CG2 . VAL A 1 51  ? 146.660 110.889 129.718 1.00 42.88  ? 51  VAL A CG2 1 
ATOM   383  N N   . GLU A 1 52  ? 144.835 111.784 133.922 1.00 42.02  ? 52  GLU A N   1 
ATOM   384  C CA  . GLU A 1 52  ? 144.181 112.511 135.012 1.00 42.02  ? 52  GLU A CA  1 
ATOM   385  C C   . GLU A 1 52  ? 142.775 111.994 135.280 1.00 42.02  ? 52  GLU A C   1 
ATOM   386  O O   . GLU A 1 52  ? 141.806 112.743 135.259 1.00 42.02  ? 52  GLU A O   1 
ATOM   387  C CB  . GLU A 1 52  ? 144.142 114.013 134.746 1.00 42.02  ? 52  GLU A CB  1 
ATOM   388  C CG  . GLU A 1 52  ? 145.472 114.717 134.825 1.00 42.02  ? 52  GLU A CG  1 
ATOM   389  C CD  . GLU A 1 52  ? 145.344 116.202 134.556 1.00 42.02  ? 52  GLU A CD  1 
ATOM   390  O OE1 . GLU A 1 52  ? 144.237 116.643 134.191 1.00 42.02  ? 52  GLU A OE1 1 
ATOM   391  O OE2 . GLU A 1 52  ? 146.341 116.931 134.715 1.00 42.02  ? 52  GLU A OE2 1 
ATOM   392  N N   . GLY A 1 53  ? 142.676 110.694 135.542 1.00 38.84  ? 53  GLY A N   1 
ATOM   393  C CA  . GLY A 1 53  ? 141.378 110.111 135.837 1.00 38.84  ? 53  GLY A CA  1 
ATOM   394  C C   . GLY A 1 53  ? 140.815 110.569 137.167 1.00 38.84  ? 53  GLY A C   1 
ATOM   395  O O   . GLY A 1 53  ? 139.607 110.741 137.309 1.00 38.84  ? 53  GLY A O   1 
ATOM   396  N N   . GLY A 1 54  ? 141.674 110.789 138.143 1.00 36.73  ? 54  GLY A N   1 
ATOM   397  C CA  . GLY A 1 54  ? 141.263 111.291 139.438 1.00 36.73  ? 54  GLY A CA  1 
ATOM   398  C C   . GLY A 1 54  ? 141.199 110.142 140.411 1.00 36.73  ? 54  GLY A C   1 
ATOM   399  O O   . GLY A 1 54  ? 140.815 109.027 140.052 1.00 36.73  ? 54  GLY A O   1 
ATOM   400  N N   . GLN A 1 55  ? 141.567 110.407 141.657 1.00 39.07  ? 55  GLN A N   1 
ATOM   401  C CA  . GLN A 1 55  ? 141.670 109.343 142.641 1.00 39.07  ? 55  GLN A CA  1 
ATOM   402  C C   . GLN A 1 55  ? 141.319 109.874 144.020 1.00 39.07  ? 55  GLN A C   1 
ATOM   403  O O   . GLN A 1 55  ? 141.516 111.051 144.318 1.00 39.07  ? 55  GLN A O   1 
ATOM   404  C CB  . GLN A 1 55  ? 143.075 108.726 142.642 1.00 39.07  ? 55  GLN A CB  1 
ATOM   405  C CG  . GLN A 1 55  ? 144.190 109.670 143.045 1.00 39.07  ? 55  GLN A CG  1 
ATOM   406  C CD  . GLN A 1 55  ? 145.562 109.038 142.964 1.00 39.07  ? 55  GLN A CD  1 
ATOM   407  O OE1 . GLN A 1 55  ? 145.698 107.879 142.606 1.00 39.07  ? 55  GLN A OE1 1 
ATOM   408  N NE2 . GLN A 1 55  ? 146.583 109.796 143.314 1.00 39.07  ? 55  GLN A NE2 1 
ATOM   409  N N   . VAL A 1 56  ? 140.785 108.994 144.853 1.00 39.78  ? 56  VAL A N   1 
ATOM   410  C CA  . VAL A 1 56  ? 140.439 109.309 146.232 1.00 39.78  ? 56  VAL A CA  1 
ATOM   411  C C   . VAL A 1 56  ? 141.440 108.633 147.147 1.00 39.78  ? 56  VAL A C   1 
ATOM   412  O O   . VAL A 1 56  ? 141.582 107.410 147.124 1.00 39.78  ? 56  VAL A O   1 
ATOM   413  C CB  . VAL A 1 56  ? 139.009 108.849 146.558 1.00 39.78  ? 56  VAL A CB  1 
ATOM   414  C CG1 . VAL A 1 56  ? 138.705 109.096 148.012 1.00 39.78  ? 56  VAL A CG1 1 
ATOM   415  C CG2 . VAL A 1 56  ? 138.020 109.560 145.686 1.00 39.78  ? 56  VAL A CG2 1 
ATOM   416  N N   . LEU A 1 57  ? 142.133 109.413 147.957 1.00 41.93  ? 57  LEU A N   1 
ATOM   417  C CA  . LEU A 1 57  ? 143.175 108.873 148.812 1.00 41.93  ? 57  LEU A CA  1 
ATOM   418  C C   . LEU A 1 57  ? 142.646 108.673 150.222 1.00 41.93  ? 57  LEU A C   1 
ATOM   419  O O   . LEU A 1 57  ? 141.573 109.155 150.581 1.00 41.93  ? 57  LEU A O   1 
ATOM   420  C CB  . LEU A 1 57  ? 144.412 109.776 148.863 1.00 41.93  ? 57  LEU A CB  1 
ATOM   421  C CG  . LEU A 1 57  ? 145.425 109.756 147.727 1.00 41.93  ? 57  LEU A CG  1 
ATOM   422  C CD1 . LEU A 1 57  ? 144.939 110.543 146.555 1.00 41.93  ? 57  LEU A CD1 1 
ATOM   423  C CD2 . LEU A 1 57  ? 146.729 110.306 148.205 1.00 41.93  ? 57  LEU A CD2 1 
ATOM   424  N N   . LYS A 1 58  ? 143.419 107.939 151.016 1.00 46.31  ? 58  LYS A N   1 
ATOM   425  C CA  . LYS A 1 58  ? 143.094 107.646 152.405 1.00 46.31  ? 58  LYS A CA  1 
ATOM   426  C C   . LYS A 1 58  ? 144.265 108.053 153.280 1.00 46.31  ? 58  LYS A C   1 
ATOM   427  O O   . LYS A 1 58  ? 145.279 107.355 153.321 1.00 46.31  ? 58  LYS A O   1 
ATOM   428  C CB  . LYS A 1 58  ? 142.791 106.164 152.590 1.00 46.31  ? 58  LYS A CB  1 
ATOM   429  C CG  . LYS A 1 58  ? 142.358 105.807 153.981 1.00 46.31  ? 58  LYS A CG  1 
ATOM   430  C CD  . LYS A 1 58  ? 142.167 104.318 154.122 1.00 46.31  ? 58  LYS A CD  1 
ATOM   431  C CE  . LYS A 1 58  ? 140.913 103.869 153.435 1.00 46.31  ? 58  LYS A CE  1 
ATOM   432  N NZ  . LYS A 1 58  ? 140.679 102.430 153.692 1.00 46.31  ? 58  LYS A NZ  1 
ATOM   433  N N   . CYS A 1 59  ? 144.122 109.167 153.986 1.00 50.63  ? 59  CYS A N   1 
ATOM   434  C CA  . CYS A 1 59  ? 145.188 109.727 154.801 1.00 50.63  ? 59  CYS A CA  1 
ATOM   435  C C   . CYS A 1 59  ? 145.069 109.222 156.226 1.00 50.63  ? 59  CYS A C   1 
ATOM   436  O O   . CYS A 1 59  ? 144.010 109.336 156.843 1.00 50.63  ? 59  CYS A O   1 
ATOM   437  C CB  . CYS A 1 59  ? 145.148 111.250 154.784 1.00 50.63  ? 59  CYS A CB  1 
ATOM   438  S SG  . CYS A 1 59  ? 145.571 112.003 153.209 1.00 50.63  ? 59  CYS A SG  1 
ATOM   439  N N   . ASP A 1 60  ? 146.161 108.678 156.746 1.00 56.66  ? 60  ASP A N   1 
ATOM   440  C CA  . ASP A 1 60  ? 146.134 108.046 158.052 1.00 56.66  ? 60  ASP A CA  1 
ATOM   441  C C   . ASP A 1 60  ? 146.184 109.089 159.152 1.00 56.66  ? 60  ASP A C   1 
ATOM   442  O O   . ASP A 1 60  ? 146.579 110.234 158.932 1.00 56.66  ? 60  ASP A O   1 
ATOM   443  C CB  . ASP A 1 60  ? 147.309 107.086 158.201 1.00 56.66  ? 60  ASP A CB  1 
ATOM   444  N N   . TRP A 1 61  ? 145.767 108.690 160.348 1.00 60.63  ? 61  TRP A N   1 
ATOM   445  C CA  . TRP A 1 61  ? 145.917 109.554 161.515 1.00 60.63  ? 61  TRP A CA  1 
ATOM   446  C C   . TRP A 1 61  ? 147.057 109.023 162.369 1.00 60.63  ? 61  TRP A C   1 
ATOM   447  O O   . TRP A 1 61  ? 146.877 108.158 163.227 1.00 60.63  ? 61  TRP A O   1 
ATOM   448  C CB  . TRP A 1 61  ? 144.617 109.662 162.298 1.00 60.63  ? 61  TRP A CB  1 
ATOM   449  C CG  . TRP A 1 61  ? 144.772 110.437 163.577 1.00 60.63  ? 61  TRP A CG  1 
ATOM   450  C CD1 . TRP A 1 61  ? 144.629 109.955 164.840 1.00 60.63  ? 61  TRP A CD1 1 
ATOM   451  C CD2 . TRP A 1 61  ? 145.180 111.802 163.716 1.00 60.63  ? 61  TRP A CD2 1 
ATOM   452  N NE1 . TRP A 1 61  ? 144.866 110.944 165.754 1.00 60.63  ? 61  TRP A NE1 1 
ATOM   453  C CE2 . TRP A 1 61  ? 145.219 112.085 165.089 1.00 60.63  ? 61  TRP A CE2 1 
ATOM   454  C CE3 . TRP A 1 61  ? 145.502 112.819 162.810 1.00 60.63  ? 61  TRP A CE3 1 
ATOM   455  C CZ2 . TRP A 1 61  ? 145.570 113.333 165.579 1.00 60.63  ? 61  TRP A CZ2 1 
ATOM   456  C CZ3 . TRP A 1 61  ? 145.854 114.052 163.298 1.00 60.63  ? 61  TRP A CZ3 1 
ATOM   457  C CH2 . TRP A 1 61  ? 145.886 114.300 164.666 1.00 60.63  ? 61  TRP A CH2 1 
ATOM   458  N N   . SER A 1 62  ? 148.253 109.550 162.125 1.00 67.27  ? 62  SER A N   1 
ATOM   459  C CA  . SER A 1 62  ? 149.451 109.078 162.804 1.00 67.27  ? 62  SER A CA  1 
ATOM   460  C C   . SER A 1 62  ? 150.476 110.201 162.820 1.00 67.27  ? 62  SER A C   1 
ATOM   461  O O   . SER A 1 62  ? 150.239 111.295 162.305 1.00 67.27  ? 62  SER A O   1 
ATOM   462  C CB  . SER A 1 62  ? 150.032 107.828 162.126 1.00 67.27  ? 62  SER A CB  1 
ATOM   463  O OG  . SER A 1 62  ? 149.149 106.722 162.212 1.00 67.27  ? 62  SER A OG  1 
ATOM   464  N N   . SER A 1 63  ? 151.622 109.914 163.435 1.00 69.32  ? 63  SER A N   1 
ATOM   465  C CA  . SER A 1 63  ? 152.740 110.847 163.378 1.00 69.32  ? 63  SER A CA  1 
ATOM   466  C C   . SER A 1 63  ? 153.376 110.835 161.996 1.00 69.32  ? 63  SER A C   1 
ATOM   467  O O   . SER A 1 63  ? 153.556 111.886 161.370 1.00 69.32  ? 63  SER A O   1 
ATOM   468  C CB  . SER A 1 63  ? 153.771 110.500 164.452 1.00 69.32  ? 63  SER A CB  1 
ATOM   469  O OG  . SER A 1 63  ? 154.381 109.251 164.184 1.00 69.32  ? 63  SER A OG  1 
ATOM   470  N N   . THR A 1 64  ? 153.718 109.648 161.499 1.00 68.50  ? 64  THR A N   1 
ATOM   471  C CA  . THR A 1 64  ? 154.222 109.466 160.140 1.00 68.50  ? 64  THR A CA  1 
ATOM   472  C C   . THR A 1 64  ? 153.026 109.160 159.241 1.00 68.50  ? 64  THR A C   1 
ATOM   473  O O   . THR A 1 64  ? 152.957 108.115 158.591 1.00 68.50  ? 64  THR A O   1 
ATOM   474  C CB  . THR A 1 64  ? 155.308 108.387 160.108 1.00 68.50  ? 64  THR A CB  1 
ATOM   475  O OG1 . THR A 1 64  ? 155.680 108.093 158.754 1.00 68.50  ? 64  THR A OG1 1 
ATOM   476  C CG2 . THR A 1 64  ? 154.917 107.110 160.895 1.00 68.50  ? 64  THR A CG2 1 
ATOM   477  N N   . ARG A 1 65  ? 152.103 110.112 159.170 1.00 63.49  ? 65  ARG A N   1 
ATOM   478  C CA  . ARG A 1 65  ? 150.835 109.942 158.481 1.00 63.49  ? 65  ARG A CA  1 
ATOM   479  C C   . ARG A 1 65  ? 151.028 110.212 157.002 1.00 63.49  ? 65  ARG A C   1 
ATOM   480  O O   . ARG A 1 65  ? 151.215 111.362 156.596 1.00 63.49  ? 65  ARG A O   1 
ATOM   481  C CB  . ARG A 1 65  ? 149.777 110.883 159.043 1.00 63.49  ? 65  ARG A CB  1 
ATOM   482  N N   . ARG A 1 66  ? 150.977 109.153 156.204 1.00 57.52  ? 66  ARG A N   1 
ATOM   483  C CA  . ARG A 1 66  ? 151.055 109.265 154.762 1.00 57.52  ? 66  ARG A CA  1 
ATOM   484  C C   . ARG A 1 66  ? 149.677 108.987 154.195 1.00 57.52  ? 66  ARG A C   1 
ATOM   485  O O   . ARG A 1 66  ? 148.780 108.516 154.893 1.00 57.52  ? 66  ARG A O   1 
ATOM   486  C CB  . ARG A 1 66  ? 152.088 108.300 154.170 1.00 57.52  ? 66  ARG A CB  1 
ATOM   487  N N   . CYS A 1 67  ? 149.515 109.293 152.917 1.00 51.77  ? 67  CYS A N   1 
ATOM   488  C CA  . CYS A 1 67  ? 148.236 109.169 152.242 1.00 51.77  ? 67  CYS A CA  1 
ATOM   489  C C   . CYS A 1 67  ? 148.361 108.171 151.103 1.00 51.77  ? 67  CYS A C   1 
ATOM   490  O O   . CYS A 1 67  ? 149.171 108.363 150.194 1.00 51.77  ? 67  CYS A O   1 
ATOM   491  C CB  . CYS A 1 67  ? 147.785 110.534 151.728 1.00 51.77  ? 67  CYS A CB  1 
ATOM   492  S SG  . CYS A 1 67  ? 147.580 111.769 153.041 1.00 51.77  ? 67  CYS A SG  1 
ATOM   493  N N   . GLN A 1 68  ? 147.566 107.110 151.157 1.00 47.11  ? 68  GLN A N   1 
ATOM   494  C CA  . GLN A 1 68  ? 147.610 106.061 150.156 1.00 47.11  ? 68  GLN A CA  1 
ATOM   495  C C   . GLN A 1 68  ? 146.341 106.070 149.325 1.00 47.11  ? 68  GLN A C   1 
ATOM   496  O O   . GLN A 1 68  ? 145.244 106.171 149.885 1.00 47.11  ? 68  GLN A O   1 
ATOM   497  C CB  . GLN A 1 68  ? 147.783 104.697 150.818 1.00 47.11  ? 68  GLN A CB  1 
ATOM   498  C CG  . GLN A 1 68  ? 149.098 104.535 151.553 1.00 47.11  ? 68  GLN A CG  1 
ATOM   499  C CD  . GLN A 1 68  ? 150.296 104.542 150.627 1.00 47.11  ? 68  GLN A CD  1 
ATOM   500  O OE1 . GLN A 1 68  ? 150.253 103.982 149.535 1.00 47.11  ? 68  GLN A OE1 1 
ATOM   501  N NE2 . GLN A 1 68  ? 151.374 105.176 151.062 1.00 47.11  ? 68  GLN A NE2 1 
ATOM   502  N N   . PRO A 1 69  ? 146.441 105.965 148.006 1.00 41.90  ? 69  PRO A N   1 
ATOM   503  C CA  . PRO A 1 69  ? 145.242 106.018 147.174 1.00 41.90  ? 69  PRO A CA  1 
ATOM   504  C C   . PRO A 1 69  ? 144.460 104.721 147.197 1.00 41.90  ? 69  PRO A C   1 
ATOM   505  O O   . PRO A 1 69  ? 145.023 103.630 147.230 1.00 41.90  ? 69  PRO A O   1 
ATOM   506  C CB  . PRO A 1 69  ? 145.801 106.304 145.783 1.00 41.90  ? 69  PRO A CB  1 
ATOM   507  C CG  . PRO A 1 69  ? 147.162 105.797 145.828 1.00 41.90  ? 69  PRO A CG  1 
ATOM   508  C CD  . PRO A 1 69  ? 147.663 106.019 147.199 1.00 41.90  ? 69  PRO A CD  1 
ATOM   509  N N   . ILE A 1 70  ? 143.146 104.856 147.160 1.00 42.45  ? 70  ILE A N   1 
ATOM   510  C CA  . ILE A 1 70  ? 142.249 103.713 147.212 1.00 42.45  ? 70  ILE A CA  1 
ATOM   511  C C   . ILE A 1 70  ? 141.954 103.255 145.796 1.00 42.45  ? 70  ILE A C   1 
ATOM   512  O O   . ILE A 1 70  ? 141.550 104.055 144.946 1.00 42.45  ? 70  ILE A O   1 
ATOM   513  C CB  . ILE A 1 70  ? 140.955 104.081 147.937 1.00 42.45  ? 70  ILE A CB  1 
ATOM   514  C CG1 . ILE A 1 70  ? 141.259 104.594 149.331 1.00 42.45  ? 70  ILE A CG1 1 
ATOM   515  C CG2 . ILE A 1 70  ? 140.082 102.887 148.048 1.00 42.45  ? 70  ILE A CG2 1 
ATOM   516  C CD1 . ILE A 1 70  ? 140.078 105.242 149.983 1.00 42.45  ? 70  ILE A CD1 1 
ATOM   517  N N   . GLU A 1 71  ? 142.138 101.962 145.537 1.00 46.16  ? 71  GLU A N   1 
ATOM   518  C CA  . GLU A 1 71  ? 141.905 101.404 144.210 1.00 46.16  ? 71  GLU A CA  1 
ATOM   519  C C   . GLU A 1 71  ? 140.429 101.068 144.081 1.00 46.16  ? 71  GLU A C   1 
ATOM   520  O O   . GLU A 1 71  ? 140.002 99.927  144.245 1.00 46.16  ? 71  GLU A O   1 
ATOM   521  C CB  . GLU A 1 71  ? 142.774 100.178 143.985 1.00 46.16  ? 71  GLU A CB  1 
ATOM   522  C CG  . GLU A 1 71  ? 144.270 100.460 143.961 1.00 46.16  ? 71  GLU A CG  1 
ATOM   523  C CD  . GLU A 1 71  ? 144.705 101.270 142.752 1.00 46.16  ? 71  GLU A CD  1 
ATOM   524  O OE1 . GLU A 1 71  ? 144.093 101.117 141.674 1.00 46.16  ? 71  GLU A OE1 1 
ATOM   525  O OE2 . GLU A 1 71  ? 145.663 102.059 142.881 1.00 46.16  ? 71  GLU A OE2 1 
ATOM   526  N N   . PHE A 1 72  ? 139.634 102.095 143.781 1.00 42.22  ? 72  PHE A N   1 
ATOM   527  C CA  . PHE A 1 72  ? 138.236 101.864 143.434 1.00 42.22  ? 72  PHE A CA  1 
ATOM   528  C C   . PHE A 1 72  ? 138.123 101.186 142.085 1.00 42.22  ? 72  PHE A C   1 
ATOM   529  O O   . PHE A 1 72  ? 137.205 100.397 141.850 1.00 42.22  ? 72  PHE A O   1 
ATOM   530  C CB  . PHE A 1 72  ? 137.468 103.180 143.410 1.00 42.22  ? 72  PHE A CB  1 
ATOM   531  C CG  . PHE A 1 72  ? 137.243 103.780 144.756 1.00 42.22  ? 72  PHE A CG  1 
ATOM   532  C CD1 . PHE A 1 72  ? 136.186 103.369 145.534 1.00 42.22  ? 72  PHE A CD1 1 
ATOM   533  C CD2 . PHE A 1 72  ? 138.083 104.759 145.235 1.00 42.22  ? 72  PHE A CD2 1 
ATOM   534  C CE1 . PHE A 1 72  ? 135.973 103.923 146.759 1.00 42.22  ? 72  PHE A CE1 1 
ATOM   535  C CE2 . PHE A 1 72  ? 137.874 105.315 146.456 1.00 42.22  ? 72  PHE A CE2 1 
ATOM   536  C CZ  . PHE A 1 72  ? 136.823 104.892 147.224 1.00 42.22  ? 72  PHE A CZ  1 
ATOM   537  N N   . ASP A 1 73  ? 139.047 101.490 141.188 1.00 43.66  ? 73  ASP A N   1 
ATOM   538  C CA  . ASP A 1 73  ? 139.040 100.987 139.829 1.00 43.66  ? 73  ASP A CA  1 
ATOM   539  C C   . ASP A 1 73  ? 140.468 100.998 139.316 1.00 43.66  ? 73  ASP A C   1 
ATOM   540  O O   . ASP A 1 73  ? 141.262 101.870 139.674 1.00 43.66  ? 73  ASP A O   1 
ATOM   541  C CB  . ASP A 1 73  ? 138.140 101.838 138.943 1.00 43.66  ? 73  ASP A CB  1 
ATOM   542  C CG  . ASP A 1 73  ? 137.986 101.284 137.562 1.00 43.66  ? 73  ASP A CG  1 
ATOM   543  O OD1 . ASP A 1 73  ? 137.310 100.250 137.411 1.00 43.66  ? 73  ASP A OD1 1 
ATOM   544  O OD2 . ASP A 1 73  ? 138.516 101.900 136.619 1.00 43.66  ? 73  ASP A OD2 1 
ATOM   545  N N   . ALA A 1 74  ? 140.796 100.009 138.495 1.00 43.34  ? 74  ALA A N   1 
ATOM   546  C CA  . ALA A 1 74  ? 142.111 99.936  137.888 1.00 43.34  ? 74  ALA A CA  1 
ATOM   547  C C   . ALA A 1 74  ? 142.054 99.632  136.402 1.00 43.34  ? 74  ALA A C   1 
ATOM   548  O O   . ALA A 1 74  ? 143.102 99.397  135.794 1.00 43.34  ? 74  ALA A O   1 
ATOM   549  C CB  . ALA A 1 74  ? 142.971 98.880  138.593 1.00 43.34  ? 74  ALA A CB  1 
ATOM   550  N N   . THR A 1 75  ? 140.873 99.630  135.804 1.00 41.63  ? 75  THR A N   1 
ATOM   551  C CA  . THR A 1 75  ? 140.721 99.275  134.410 1.00 41.63  ? 75  THR A CA  1 
ATOM   552  C C   . THR A 1 75  ? 140.739 100.519 133.535 1.00 41.63  ? 75  THR A C   1 
ATOM   553  O O   . THR A 1 75  ? 140.605 101.646 134.005 1.00 41.63  ? 75  THR A O   1 
ATOM   554  C CB  . THR A 1 75  ? 139.425 98.517  134.208 1.00 41.63  ? 75  THR A CB  1 
ATOM   555  O OG1 . THR A 1 75  ? 138.334 99.381  134.519 1.00 41.63  ? 75  THR A OG1 1 
ATOM   556  C CG2 . THR A 1 75  ? 139.377 97.344  135.134 1.00 41.63  ? 75  THR A CG2 1 
ATOM   557  N N   . GLY A 1 76  ? 140.910 100.301 132.244 1.00 42.77  ? 76  GLY A N   1 
ATOM   558  C CA  . GLY A 1 76  ? 140.837 101.358 131.265 1.00 42.77  ? 76  GLY A CA  1 
ATOM   559  C C   . GLY A 1 76  ? 139.426 101.552 130.770 1.00 42.77  ? 76  GLY A C   1 
ATOM   560  O O   . GLY A 1 76  ? 138.450 101.186 131.425 1.00 42.77  ? 76  GLY A O   1 
ATOM   561  N N   . ASN A 1 77  ? 139.318 102.133 129.588 1.00 43.77  ? 77  ASN A N   1 
ATOM   562  C CA  . ASN A 1 77  ? 138.021 102.342 128.968 1.00 43.77  ? 77  ASN A CA  1 
ATOM   563  C C   . ASN A 1 77  ? 137.538 101.030 128.378 1.00 43.77  ? 77  ASN A C   1 
ATOM   564  O O   . ASN A 1 77  ? 138.237 100.415 127.572 1.00 43.77  ? 77  ASN A O   1 
ATOM   565  C CB  . ASN A 1 77  ? 138.117 103.406 127.883 1.00 43.77  ? 77  ASN A CB  1 
ATOM   566  C CG  . ASN A 1 77  ? 138.412 104.773 128.438 1.00 43.77  ? 77  ASN A CG  1 
ATOM   567  O OD1 . ASN A 1 77  ? 137.847 105.170 129.442 1.00 43.77  ? 77  ASN A OD1 1 
ATOM   568  N ND2 . ASN A 1 77  ? 139.307 105.501 127.788 1.00 43.77  ? 77  ASN A ND2 1 
ATOM   569  N N   . ARG A 1 78  ? 136.357 100.592 128.784 1.00 45.63  ? 78  ARG A N   1 
ATOM   570  C CA  . ARG A 1 78  ? 135.752 99.446  128.137 1.00 45.63  ? 78  ARG A CA  1 
ATOM   571  C C   . ARG A 1 78  ? 135.312 99.816  126.730 1.00 45.63  ? 78  ARG A C   1 
ATOM   572  O O   . ARG A 1 78  ? 135.146 100.988 126.389 1.00 45.63  ? 78  ARG A O   1 
ATOM   573  C CB  . ARG A 1 78  ? 134.560 98.945  128.936 1.00 45.63  ? 78  ARG A CB  1 
ATOM   574  C CG  . ARG A 1 78  ? 134.927 98.302  130.245 1.00 45.63  ? 78  ARG A CG  1 
ATOM   575  C CD  . ARG A 1 78  ? 133.681 97.875  130.973 1.00 45.63  ? 78  ARG A CD  1 
ATOM   576  N NE  . ARG A 1 78  ? 132.921 99.032  131.418 1.00 45.63  ? 78  ARG A NE  1 
ATOM   577  C CZ  . ARG A 1 78  ? 131.695 98.966  131.911 1.00 45.63  ? 78  ARG A CZ  1 
ATOM   578  N NH1 . ARG A 1 78  ? 131.086 97.796  132.012 1.00 45.63  ? 78  ARG A NH1 1 
ATOM   579  N NH2 . ARG A 1 78  ? 131.076 100.070 132.297 1.00 45.63  ? 78  ARG A NH2 1 
ATOM   580  N N   . ASP A 1 79  ? 135.124 98.796  125.902 1.00 47.30  ? 79  ASP A N   1 
ATOM   581  C CA  . ASP A 1 79  ? 134.786 98.987  124.505 1.00 47.30  ? 79  ASP A CA  1 
ATOM   582  C C   . ASP A 1 79  ? 133.372 98.507  124.232 1.00 47.30  ? 79  ASP A C   1 
ATOM   583  O O   . ASP A 1 79  ? 132.910 97.534  124.827 1.00 47.30  ? 79  ASP A O   1 
ATOM   584  C CB  . ASP A 1 79  ? 135.762 98.242  123.605 1.00 47.30  ? 79  ASP A CB  1 
ATOM   585  C CG  . ASP A 1 79  ? 137.149 98.828  123.647 1.00 47.30  ? 79  ASP A CG  1 
ATOM   586  O OD1 . ASP A 1 79  ? 137.276 100.038 123.912 1.00 47.30  ? 79  ASP A OD1 1 
ATOM   587  O OD2 . ASP A 1 79  ? 138.117 98.078  123.412 1.00 47.30  ? 79  ASP A OD2 1 
ATOM   588  N N   . TYR A 1 80  ? 132.687 99.209  123.339 1.00 48.10  ? 80  TYR A N   1 
ATOM   589  C CA  . TYR A 1 80  ? 131.404 98.743  122.840 1.00 48.10  ? 80  TYR A CA  1 
ATOM   590  C C   . TYR A 1 80  ? 131.599 97.677  121.778 1.00 48.10  ? 80  TYR A C   1 
ATOM   591  O O   . TYR A 1 80  ? 130.865 96.685  121.741 1.00 48.10  ? 80  TYR A O   1 
ATOM   592  C CB  . TYR A 1 80  ? 130.616 99.920  122.276 1.00 48.10  ? 80  TYR A CB  1 
ATOM   593  C CG  . TYR A 1 80  ? 129.261 99.582  121.721 1.00 48.10  ? 80  TYR A CG  1 
ATOM   594  C CD1 . TYR A 1 80  ? 128.180 99.372  122.557 1.00 48.10  ? 80  TYR A CD1 1 
ATOM   595  C CD2 . TYR A 1 80  ? 129.058 99.491  120.354 1.00 48.10  ? 80  TYR A CD2 1 
ATOM   596  C CE1 . TYR A 1 80  ? 126.934 99.075  122.046 1.00 48.10  ? 80  TYR A CE1 1 
ATOM   597  C CE2 . TYR A 1 80  ? 127.819 99.191  119.835 1.00 48.10  ? 80  TYR A CE2 1 
ATOM   598  C CZ  . TYR A 1 80  ? 126.764 98.987  120.684 1.00 48.10  ? 80  TYR A CZ  1 
ATOM   599  O OH  . TYR A 1 80  ? 125.531 98.688  120.163 1.00 48.10  ? 80  TYR A OH  1 
ATOM   600  N N   . ALA A 1 81  ? 132.578 97.875  120.907 1.00 51.54  ? 81  ALA A N   1 
ATOM   601  C CA  . ALA A 1 81  ? 132.930 96.921  119.875 1.00 51.54  ? 81  ALA A CA  1 
ATOM   602  C C   . ALA A 1 81  ? 134.426 97.045  119.630 1.00 51.54  ? 81  ALA A C   1 
ATOM   603  O O   . ALA A 1 81  ? 135.150 97.649  120.423 1.00 51.54  ? 81  ALA A O   1 
ATOM   604  C CB  . ALA A 1 81  ? 132.102 97.164  118.609 1.00 51.54  ? 81  ALA A CB  1 
ATOM   605  N N   . LYS A 1 82  ? 134.896 96.472  118.532 1.00 52.83  ? 82  LYS A N   1 
ATOM   606  C CA  . LYS A 1 82  ? 136.310 96.553  118.207 1.00 52.83  ? 82  LYS A CA  1 
ATOM   607  C C   . LYS A 1 82  ? 136.654 97.956  117.742 1.00 52.83  ? 82  LYS A C   1 
ATOM   608  O O   . LYS A 1 82  ? 136.017 98.478  116.823 1.00 52.83  ? 82  LYS A O   1 
ATOM   609  C CB  . LYS A 1 82  ? 136.661 95.530  117.131 1.00 52.83  ? 82  LYS A CB  1 
ATOM   610  N N   . ASP A 1 83  ? 137.656 98.555  118.397 1.00 52.70  ? 83  ASP A N   1 
ATOM   611  C CA  . ASP A 1 83  ? 138.146 99.912  118.124 1.00 52.70  ? 83  ASP A CA  1 
ATOM   612  C C   . ASP A 1 83  ? 137.028 100.951 118.236 1.00 52.70  ? 83  ASP A C   1 
ATOM   613  O O   . ASP A 1 83  ? 136.888 101.844 117.399 1.00 52.70  ? 83  ASP A O   1 
ATOM   614  C CB  . ASP A 1 83  ? 138.845 99.992  116.763 1.00 52.70  ? 83  ASP A CB  1 
ATOM   615  N N   . ASP A 1 84  ? 136.226 100.820 119.290 1.00 49.37  ? 84  ASP A N   1 
ATOM   616  C CA  . ASP A 1 84  ? 135.114 101.734 119.547 1.00 49.37  ? 84  ASP A CA  1 
ATOM   617  C C   . ASP A 1 84  ? 134.848 101.737 121.036 1.00 49.37  ? 84  ASP A C   1 
ATOM   618  O O   . ASP A 1 84  ? 134.199 100.828 121.564 1.00 49.37  ? 84  ASP A O   1 
ATOM   619  C CB  . ASP A 1 84  ? 133.859 101.328 118.781 1.00 49.37  ? 84  ASP A CB  1 
ATOM   620  C CG  . ASP A 1 84  ? 132.714 102.281 119.005 1.00 49.37  ? 84  ASP A CG  1 
ATOM   621  O OD1 . ASP A 1 84  ? 132.756 103.402 118.460 1.00 49.37  ? 84  ASP A OD1 1 
ATOM   622  O OD2 . ASP A 1 84  ? 131.769 101.912 119.729 1.00 49.37  ? 84  ASP A OD2 1 
ATOM   623  N N   . PRO A 1 85  ? 135.353 102.736 121.757 1.00 46.25  ? 85  PRO A N   1 
ATOM   624  C CA  . PRO A 1 85  ? 135.228 102.728 123.214 1.00 46.25  ? 85  PRO A CA  1 
ATOM   625  C C   . PRO A 1 85  ? 133.800 102.981 123.653 1.00 46.25  ? 85  PRO A C   1 
ATOM   626  O O   . PRO A 1 85  ? 133.112 103.845 123.114 1.00 46.25  ? 85  PRO A O   1 
ATOM   627  C CB  . PRO A 1 85  ? 136.147 103.869 123.651 1.00 46.25  ? 85  PRO A CB  1 
ATOM   628  C CG  . PRO A 1 85  ? 137.062 104.075 122.531 1.00 46.25  ? 85  PRO A CG  1 
ATOM   629  C CD  . PRO A 1 85  ? 136.259 103.801 121.308 1.00 46.25  ? 85  PRO A CD  1 
ATOM   630  N N   . LEU A 1 86  ? 133.357 102.205 124.633 1.00 44.24  ? 86  LEU A N   1 
ATOM   631  C CA  . LEU A 1 86  ? 132.078 102.432 125.282 1.00 44.24  ? 86  LEU A CA  1 
ATOM   632  C C   . LEU A 1 86  ? 132.091 103.655 126.180 1.00 44.24  ? 86  LEU A C   1 
ATOM   633  O O   . LEU A 1 86  ? 131.057 104.306 126.355 1.00 44.24  ? 86  LEU A O   1 
ATOM   634  C CB  . LEU A 1 86  ? 131.702 101.213 126.120 1.00 44.24  ? 86  LEU A CB  1 
ATOM   635  C CG  . LEU A 1 86  ? 130.375 101.212 126.865 1.00 44.24  ? 86  LEU A CG  1 
ATOM   636  C CD1 . LEU A 1 86  ? 129.201 101.077 125.929 1.00 44.24  ? 86  LEU A CD1 1 
ATOM   637  C CD2 . LEU A 1 86  ? 130.392 100.142 127.904 1.00 44.24  ? 86  LEU A CD2 1 
ATOM   638  N N   . GLU A 1 87  ? 133.238 103.999 126.733 1.00 43.07  ? 87  GLU A N   1 
ATOM   639  C CA  . GLU A 1 87  ? 133.264 104.989 127.785 1.00 43.07  ? 87  GLU A CA  1 
ATOM   640  C C   . GLU A 1 87  ? 134.580 105.739 127.727 1.00 43.07  ? 87  GLU A C   1 
ATOM   641  O O   . GLU A 1 87  ? 135.516 105.343 127.033 1.00 43.07  ? 87  GLU A O   1 
ATOM   642  C CB  . GLU A 1 87  ? 133.042 104.316 129.125 1.00 43.07  ? 87  GLU A CB  1 
ATOM   643  C CG  . GLU A 1 87  ? 134.082 103.296 129.445 1.00 43.07  ? 87  GLU A CG  1 
ATOM   644  C CD  . GLU A 1 87  ? 133.705 102.464 130.629 1.00 43.07  ? 87  GLU A CD  1 
ATOM   645  O OE1 . GLU A 1 87  ? 132.598 102.668 131.163 1.00 43.07  ? 87  GLU A OE1 1 
ATOM   646  O OE2 . GLU A 1 87  ? 134.505 101.596 131.024 1.00 43.07  ? 87  GLU A OE2 1 
ATOM   647  N N   . PHE A 1 88  ? 134.633 106.846 128.460 1.00 40.98  ? 88  PHE A N   1 
ATOM   648  C CA  . PHE A 1 88  ? 135.742 107.786 128.381 1.00 40.98  ? 88  PHE A CA  1 
ATOM   649  C C   . PHE A 1 88  ? 136.048 108.234 129.800 1.00 40.98  ? 88  PHE A C   1 
ATOM   650  O O   . PHE A 1 88  ? 135.247 108.942 130.409 1.00 40.98  ? 88  PHE A O   1 
ATOM   651  C CB  . PHE A 1 88  ? 135.374 108.975 127.500 1.00 40.98  ? 88  PHE A CB  1 
ATOM   652  C CG  . PHE A 1 88  ? 134.926 108.589 126.116 1.00 40.98  ? 88  PHE A CG  1 
ATOM   653  C CD1 . PHE A 1 88  ? 135.841 108.282 125.133 1.00 40.98  ? 88  PHE A CD1 1 
ATOM   654  C CD2 . PHE A 1 88  ? 133.581 108.508 125.811 1.00 40.98  ? 88  PHE A CD2 1 
ATOM   655  C CE1 . PHE A 1 88  ? 135.417 107.931 123.874 1.00 40.98  ? 88  PHE A CE1 1 
ATOM   656  C CE2 . PHE A 1 88  ? 133.163 108.145 124.560 1.00 40.98  ? 88  PHE A CE2 1 
ATOM   657  C CZ  . PHE A 1 88  ? 134.077 107.862 123.594 1.00 40.98  ? 88  PHE A CZ  1 
ATOM   658  N N   . LYS A 1 89  ? 137.197 107.833 130.328 1.00 40.34  ? 89  LYS A N   1 
ATOM   659  C CA  . LYS A 1 89  ? 137.506 108.031 131.733 1.00 40.34  ? 89  LYS A CA  1 
ATOM   660  C C   . LYS A 1 89  ? 138.623 109.024 131.992 1.00 40.34  ? 89  LYS A C   1 
ATOM   661  O O   . LYS A 1 89  ? 138.930 109.282 133.155 1.00 40.34  ? 89  LYS A O   1 
ATOM   662  C CB  . LYS A 1 89  ? 137.898 106.704 132.379 1.00 40.34  ? 89  LYS A CB  1 
ATOM   663  C CG  . LYS A 1 89  ? 136.816 105.675 132.494 1.00 40.34  ? 89  LYS A CG  1 
ATOM   664  C CD  . LYS A 1 89  ? 137.407 104.406 133.054 1.00 40.34  ? 89  LYS A CD  1 
ATOM   665  C CE  . LYS A 1 89  ? 136.376 103.320 133.116 1.00 40.34  ? 89  LYS A CE  1 
ATOM   666  N NZ  . LYS A 1 89  ? 136.949 102.039 133.577 1.00 40.34  ? 89  LYS A NZ  1 
ATOM   667  N N   . SER A 1 90  ? 139.274 109.555 130.973 1.00 41.19  ? 90  SER A N   1 
ATOM   668  C CA  . SER A 1 90  ? 140.298 110.557 131.221 1.00 41.19  ? 90  SER A CA  1 
ATOM   669  C C   . SER A 1 90  ? 139.628 111.888 131.526 1.00 41.19  ? 90  SER A C   1 
ATOM   670  O O   . SER A 1 90  ? 138.626 112.238 130.895 1.00 41.19  ? 90  SER A O   1 
ATOM   671  C CB  . SER A 1 90  ? 141.240 110.685 130.029 1.00 41.19  ? 90  SER A CB  1 
ATOM   672  O OG  . SER A 1 90  ? 140.563 111.195 128.899 1.00 41.19  ? 90  SER A OG  1 
ATOM   673  N N   . HIS A 1 91  ? 140.174 112.602 132.513 1.00 40.07  ? 91  HIS A N   1 
ATOM   674  C CA  . HIS A 1 91  ? 139.666 113.864 133.048 1.00 40.07  ? 91  HIS A CA  1 
ATOM   675  C C   . HIS A 1 91  ? 138.241 113.744 133.587 1.00 40.07  ? 91  HIS A C   1 
ATOM   676  O O   . HIS A 1 91  ? 137.463 114.694 133.490 1.00 40.07  ? 91  HIS A O   1 
ATOM   677  C CB  . HIS A 1 91  ? 139.728 114.989 132.006 1.00 40.07  ? 91  HIS A CB  1 
ATOM   678  C CG  . HIS A 1 91  ? 141.062 115.147 131.348 1.00 40.07  ? 91  HIS A CG  1 
ATOM   679  N ND1 . HIS A 1 91  ? 142.150 115.699 131.983 1.00 40.07  ? 91  HIS A ND1 1 
ATOM   680  C CD2 . HIS A 1 91  ? 141.470 114.851 130.095 1.00 40.07  ? 91  HIS A CD2 1 
ATOM   681  C CE1 . HIS A 1 91  ? 143.176 115.718 131.155 1.00 40.07  ? 91  HIS A CE1 1 
ATOM   682  N NE2 . HIS A 1 91  ? 142.790 115.206 130.003 1.00 40.07  ? 91  HIS A NE2 1 
ATOM   683  N N   . GLN A 1 92  ? 137.864 112.600 134.163 1.00 37.76  ? 92  GLN A N   1 
ATOM   684  C CA  . GLN A 1 92  ? 136.471 112.383 134.543 1.00 37.76  ? 92  GLN A CA  1 
ATOM   685  C C   . GLN A 1 92  ? 136.134 112.930 135.916 1.00 37.76  ? 92  GLN A C   1 
ATOM   686  O O   . GLN A 1 92  ? 134.981 112.798 136.331 1.00 37.76  ? 92  GLN A O   1 
ATOM   687  C CB  . GLN A 1 92  ? 136.129 110.901 134.531 1.00 37.76  ? 92  GLN A CB  1 
ATOM   688  C CG  . GLN A 1 92  ? 136.874 110.166 135.603 1.00 37.76  ? 92  GLN A CG  1 
ATOM   689  C CD  . GLN A 1 92  ? 136.576 108.712 135.656 1.00 37.76  ? 92  GLN A CD  1 
ATOM   690  O OE1 . GLN A 1 92  ? 135.693 108.227 134.974 1.00 37.76  ? 92  GLN A OE1 1 
ATOM   691  N NE2 . GLN A 1 92  ? 137.333 107.992 136.455 1.00 37.76  ? 92  GLN A NE2 1 
ATOM   692  N N   . TRP A 1 93  ? 137.114 113.485 136.632 1.00 38.40  ? 93  TRP A N   1 
ATOM   693  C CA  . TRP A 1 93  ? 136.934 114.151 137.931 1.00 38.40  ? 93  TRP A CA  1 
ATOM   694  C C   . TRP A 1 93  ? 136.416 113.202 139.008 1.00 38.40  ? 93  TRP A C   1 
ATOM   695  O O   . TRP A 1 93  ? 135.575 113.558 139.828 1.00 38.40  ? 93  TRP A O   1 
ATOM   696  C CB  . TRP A 1 93  ? 136.051 115.395 137.794 1.00 38.40  ? 93  TRP A CB  1 
ATOM   697  C CG  . TRP A 1 93  ? 136.820 116.514 137.226 1.00 38.40  ? 93  TRP A CG  1 
ATOM   698  C CD1 . TRP A 1 93  ? 137.212 116.652 135.945 1.00 38.40  ? 93  TRP A CD1 1 
ATOM   699  C CD2 . TRP A 1 93  ? 137.215 117.704 137.894 1.00 38.40  ? 93  TRP A CD2 1 
ATOM   700  N NE1 . TRP A 1 93  ? 137.890 117.821 135.774 1.00 38.40  ? 93  TRP A NE1 1 
ATOM   701  C CE2 . TRP A 1 93  ? 137.894 118.494 136.962 1.00 38.40  ? 93  TRP A CE2 1 
ATOM   702  C CE3 . TRP A 1 93  ? 137.074 118.174 139.199 1.00 38.40  ? 93  TRP A CE3 1 
ATOM   703  C CZ2 . TRP A 1 93  ? 138.451 119.721 137.292 1.00 38.40  ? 93  TRP A CZ2 1 
ATOM   704  C CZ3 . TRP A 1 93  ? 137.620 119.390 139.525 1.00 38.40  ? 93  TRP A CZ3 1 
ATOM   705  C CH2 . TRP A 1 93  ? 138.290 120.157 138.575 1.00 38.40  ? 93  TRP A CH2 1 
ATOM   706  N N   . PHE A 1 94  ? 136.973 111.997 139.033 1.00 36.70  ? 94  PHE A N   1 
ATOM   707  C CA  . PHE A 1 94  ? 136.713 111.057 140.111 1.00 36.70  ? 94  PHE A CA  1 
ATOM   708  C C   . PHE A 1 94  ? 137.365 111.557 141.389 1.00 36.70  ? 94  PHE A C   1 
ATOM   709  O O   . PHE A 1 94  ? 138.589 111.587 141.494 1.00 36.70  ? 94  PHE A O   1 
ATOM   710  C CB  . PHE A 1 94  ? 137.243 109.677 139.743 1.00 36.70  ? 94  PHE A CB  1 
ATOM   711  C CG  . PHE A 1 94  ? 137.010 108.647 140.795 1.00 36.70  ? 94  PHE A CG  1 
ATOM   712  C CD1 . PHE A 1 94  ? 135.761 108.105 140.972 1.00 36.70  ? 94  PHE A CD1 1 
ATOM   713  C CD2 . PHE A 1 94  ? 138.040 108.227 141.611 1.00 36.70  ? 94  PHE A CD2 1 
ATOM   714  C CE1 . PHE A 1 94  ? 135.540 107.171 141.939 1.00 36.70  ? 94  PHE A CE1 1 
ATOM   715  C CE2 . PHE A 1 94  ? 137.825 107.297 142.578 1.00 36.70  ? 94  PHE A CE2 1 
ATOM   716  C CZ  . PHE A 1 94  ? 136.573 106.764 142.741 1.00 36.70  ? 94  PHE A CZ  1 
ATOM   717  N N   . GLY A 1 95  ? 136.559 111.933 142.363 1.00 37.47  ? 95  GLY A N   1 
ATOM   718  C CA  . GLY A 1 95  ? 137.114 112.499 143.570 1.00 37.47  ? 95  GLY A CA  1 
ATOM   719  C C   . GLY A 1 95  ? 136.599 113.897 143.831 1.00 37.47  ? 95  GLY A C   1 
ATOM   720  O O   . GLY A 1 95  ? 137.040 114.573 144.761 1.00 37.47  ? 95  GLY A O   1 
ATOM   721  N N   . ALA A 1 96  ? 135.672 114.346 142.996 1.00 38.54  ? 96  ALA A N   1 
ATOM   722  C CA  . ALA A 1 96  ? 134.968 115.592 143.240 1.00 38.54  ? 96  ALA A CA  1 
ATOM   723  C C   . ALA A 1 96  ? 133.850 115.435 144.254 1.00 38.54  ? 96  ALA A C   1 
ATOM   724  O O   . ALA A 1 96  ? 133.282 116.438 144.690 1.00 38.54  ? 96  ALA A O   1 
ATOM   725  C CB  . ALA A 1 96  ? 134.405 116.140 141.929 1.00 38.54  ? 96  ALA A CB  1 
ATOM   726  N N   . SER A 1 97  ? 133.528 114.204 144.634 1.00 38.78  ? 97  SER A N   1 
ATOM   727  C CA  . SER A 1 97  ? 132.512 113.921 145.632 1.00 38.78  ? 97  SER A CA  1 
ATOM   728  C C   . SER A 1 97  ? 133.010 112.762 146.473 1.00 38.78  ? 97  SER A C   1 
ATOM   729  O O   . SER A 1 97  ? 133.092 111.641 145.977 1.00 38.78  ? 97  SER A O   1 
ATOM   730  C CB  . SER A 1 97  ? 131.188 113.579 144.963 1.00 38.78  ? 97  SER A CB  1 
ATOM   731  O OG  . SER A 1 97  ? 130.723 114.662 144.193 1.00 38.78  ? 97  SER A OG  1 
ATOM   732  N N   . VAL A 1 98  ? 133.360 113.029 147.731 1.00 40.30  ? 98  VAL A N   1 
ATOM   733  C CA  . VAL A 1 98  ? 133.928 112.029 148.636 1.00 40.30  ? 98  VAL A CA  1 
ATOM   734  C C   . VAL A 1 98  ? 133.047 111.990 149.875 1.00 40.30  ? 98  VAL A C   1 
ATOM   735  O O   . VAL A 1 98  ? 132.913 112.999 150.569 1.00 40.30  ? 98  VAL A O   1 
ATOM   736  C CB  . VAL A 1 98  ? 135.378 112.342 149.023 1.00 40.30  ? 98  VAL A CB  1 
ATOM   737  C CG1 . VAL A 1 98  ? 135.852 111.370 150.028 1.00 40.30  ? 98  VAL A CG1 1 
ATOM   738  C CG2 . VAL A 1 98  ? 136.274 112.293 147.816 1.00 40.30  ? 98  VAL A CG2 1 
ATOM   739  N N   . ARG A 1 99  ? 132.460 110.835 150.162 1.00 43.66  ? 99  ARG A N   1 
ATOM   740  C CA  . ARG A 1 99  ? 131.404 110.732 151.155 1.00 43.66  ? 99  ARG A CA  1 
ATOM   741  C C   . ARG A 1 99  ? 131.414 109.348 151.787 1.00 43.66  ? 99  ARG A C   1 
ATOM   742  O O   . ARG A 1 99  ? 131.460 108.333 151.092 1.00 43.66  ? 99  ARG A O   1 
ATOM   743  C CB  . ARG A 1 99  ? 130.052 111.029 150.517 1.00 43.66  ? 99  ARG A CB  1 
ATOM   744  C CG  . ARG A 1 99  ? 128.908 110.982 151.452 1.00 43.66  ? 99  ARG A CG  1 
ATOM   745  C CD  . ARG A 1 99  ? 129.070 112.018 152.521 1.00 43.66  ? 99  ARG A CD  1 
ATOM   746  N NE  . ARG A 1 99  ? 127.975 111.976 153.475 1.00 43.66  ? 99  ARG A NE  1 
ATOM   747  C CZ  . ARG A 1 99  ? 128.014 112.571 154.655 1.00 43.66  ? 99  ARG A CZ  1 
ATOM   748  N NH1 . ARG A 1 99  ? 129.102 113.230 155.008 1.00 43.66  ? 99  ARG A NH1 1 
ATOM   749  N NH2 . ARG A 1 99  ? 126.979 112.493 155.477 1.00 43.66  ? 99  ARG A NH2 1 
ATOM   750  N N   . SER A 1 100 ? 131.366 109.305 153.120 1.00 43.68  ? 100 SER A N   1 
ATOM   751  C CA  . SER A 1 100 ? 131.652 108.061 153.827 1.00 43.68  ? 100 SER A CA  1 
ATOM   752  C C   . SER A 1 100 ? 130.727 107.817 155.003 1.00 43.68  ? 100 SER A C   1 
ATOM   753  O O   . SER A 1 100 ? 130.503 108.710 155.818 1.00 43.68  ? 100 SER A O   1 
ATOM   754  C CB  . SER A 1 100 ? 133.083 108.043 154.336 1.00 43.68  ? 100 SER A CB  1 
ATOM   755  O OG  . SER A 1 100 ? 133.309 106.858 155.058 1.00 43.68  ? 100 SER A OG  1 
ATOM   756  N N   . LYS A 1 101 ? 130.222 106.593 155.104 1.00 46.37  ? 101 LYS A N   1 
ATOM   757  C CA  . LYS A 1 101 ? 129.449 106.156 156.261 1.00 46.37  ? 101 LYS A CA  1 
ATOM   758  C C   . LYS A 1 101 ? 129.903 104.755 156.683 1.00 46.37  ? 101 LYS A C   1 
ATOM   759  O O   . LYS A 1 101 ? 129.378 103.748 156.202 1.00 46.37  ? 101 LYS A O   1 
ATOM   760  C CB  . LYS A 1 101 ? 127.985 106.190 155.973 1.00 46.37  ? 101 LYS A CB  1 
ATOM   761  C CG  . LYS A 1 101 ? 127.172 105.944 157.205 1.00 46.37  ? 101 LYS A CG  1 
ATOM   762  C CD  . LYS A 1 101 ? 125.710 105.943 156.938 1.00 46.37  ? 101 LYS A CD  1 
ATOM   763  C CE  . LYS A 1 101 ? 124.986 105.596 158.210 1.00 46.37  ? 101 LYS A CE  1 
ATOM   764  N NZ  . LYS A 1 101 ? 123.538 105.450 157.987 1.00 46.37  ? 101 LYS A NZ  1 
ATOM   765  N N   . GLN A 1 102 ? 130.937 104.718 157.528 1.00 50.26  ? 102 GLN A N   1 
ATOM   766  C CA  . GLN A 1 102 ? 131.255 103.679 158.507 1.00 50.26  ? 102 GLN A CA  1 
ATOM   767  C C   . GLN A 1 102 ? 131.786 102.352 157.984 1.00 50.26  ? 102 GLN A C   1 
ATOM   768  O O   . GLN A 1 102 ? 132.362 101.592 158.758 1.00 50.26  ? 102 GLN A O   1 
ATOM   769  C CB  . GLN A 1 102 ? 130.004 103.360 159.327 1.00 50.26  ? 102 GLN A CB  1 
ATOM   770  C CG  . GLN A 1 102 ? 129.488 104.485 160.161 1.00 50.26  ? 102 GLN A CG  1 
ATOM   771  C CD  . GLN A 1 102 ? 128.149 104.153 160.754 1.00 50.26  ? 102 GLN A CD  1 
ATOM   772  O OE1 . GLN A 1 102 ? 127.584 103.100 160.472 1.00 50.26  ? 102 GLN A OE1 1 
ATOM   773  N NE2 . GLN A 1 102 ? 127.621 105.052 161.569 1.00 50.26  ? 102 GLN A NE2 1 
ATOM   774  N N   . ASP A 1 103 ? 131.576 102.028 156.719 1.00 49.96  ? 103 ASP A N   1 
ATOM   775  C CA  . ASP A 1 103 ? 132.328 100.998 156.015 1.00 49.96  ? 103 ASP A CA  1 
ATOM   776  C C   . ASP A 1 103 ? 132.421 101.437 154.574 1.00 49.96  ? 103 ASP A C   1 
ATOM   777  O O   . ASP A 1 103 ? 133.256 100.960 153.803 1.00 49.96  ? 103 ASP A O   1 
ATOM   778  C CB  . ASP A 1 103 ? 131.653 99.628  156.089 1.00 49.96  ? 103 ASP A CB  1 
ATOM   779  C CG  . ASP A 1 103 ? 131.984 98.870  157.349 1.00 49.96  ? 103 ASP A CG  1 
ATOM   780  O OD1 . ASP A 1 103 ? 133.130 98.978  157.828 1.00 49.96  ? 103 ASP A OD1 1 
ATOM   781  O OD2 . ASP A 1 103 ? 131.094 98.164  157.866 1.00 49.96  ? 103 ASP A OD2 1 
ATOM   782  N N   . LYS A 1 104 ? 131.548 102.367 154.229 1.00 44.85  ? 104 LYS A N   1 
ATOM   783  C CA  . LYS A 1 104 ? 131.157 102.617 152.861 1.00 44.85  ? 104 LYS A CA  1 
ATOM   784  C C   . LYS A 1 104 ? 131.794 103.914 152.431 1.00 44.85  ? 104 LYS A C   1 
ATOM   785  O O   . LYS A 1 104 ? 131.693 104.909 153.141 1.00 44.85  ? 104 LYS A O   1 
ATOM   786  C CB  . LYS A 1 104 ? 129.643 102.697 152.755 1.00 44.85  ? 104 LYS A CB  1 
ATOM   787  C CG  . LYS A 1 104 ? 128.972 101.432 153.181 1.00 44.85  ? 104 LYS A CG  1 
ATOM   788  C CD  . LYS A 1 104 ? 127.486 101.558 153.054 1.00 44.85  ? 104 LYS A CD  1 
ATOM   789  C CE  . LYS A 1 104 ? 126.946 102.509 154.096 1.00 44.85  ? 104 LYS A CE  1 
ATOM   790  N NZ  . LYS A 1 104 ? 127.154 101.970 155.469 1.00 44.85  ? 104 LYS A NZ  1 
ATOM   791  N N   . ILE A 1 105 ? 132.483 103.893 151.302 1.00 41.49  ? 105 ILE A N   1 
ATOM   792  C CA  . ILE A 1 105 ? 133.043 105.090 150.707 1.00 41.49  ? 105 ILE A CA  1 
ATOM   793  C C   . ILE A 1 105 ? 132.424 105.236 149.329 1.00 41.49  ? 105 ILE A C   1 
ATOM   794  O O   . ILE A 1 105 ? 132.748 104.473 148.412 1.00 41.49  ? 105 ILE A O   1 
ATOM   795  C CB  . ILE A 1 105 ? 134.569 105.022 150.619 1.00 41.49  ? 105 ILE A CB  1 
ATOM   796  C CG1 . ILE A 1 105 ? 135.165 104.794 151.988 1.00 41.49  ? 105 ILE A CG1 1 
ATOM   797  C CG2 . ILE A 1 105 ? 135.106 106.315 150.085 1.00 41.49  ? 105 ILE A CG2 1 
ATOM   798  C CD1 . ILE A 1 105 ? 136.618 104.520 151.945 1.00 41.49  ? 105 ILE A CD1 1 
ATOM   799  N N   . LEU A 1 106 ? 131.531 106.203 149.179 1.00 39.61  ? 106 LEU A N   1 
ATOM   800  C CA  . LEU A 1 106 ? 130.942 106.530 147.891 1.00 39.61  ? 106 LEU A CA  1 
ATOM   801  C C   . LEU A 1 106 ? 131.722 107.679 147.280 1.00 39.61  ? 106 LEU A C   1 
ATOM   802  O O   . LEU A 1 106 ? 131.771 108.770 147.851 1.00 39.61  ? 106 LEU A O   1 
ATOM   803  C CB  . LEU A 1 106 ? 129.479 106.911 148.032 1.00 39.61  ? 106 LEU A CB  1 
ATOM   804  C CG  . LEU A 1 106 ? 128.928 107.221 146.661 1.00 39.61  ? 106 LEU A CG  1 
ATOM   805  C CD1 . LEU A 1 106 ? 128.904 105.972 145.833 1.00 39.61  ? 106 LEU A CD1 1 
ATOM   806  C CD2 . LEU A 1 106 ? 127.576 107.782 146.779 1.00 39.61  ? 106 LEU A CD2 1 
ATOM   807  N N   . ALA A 1 107 ? 132.331 107.433 146.130 1.00 40.16  ? 107 ALA A N   1 
ATOM   808  C CA  . ALA A 1 107 ? 133.110 108.439 145.429 1.00 40.16  ? 107 ALA A CA  1 
ATOM   809  C C   . ALA A 1 107 ? 132.610 108.518 144.000 1.00 40.16  ? 107 ALA A C   1 
ATOM   810  O O   . ALA A 1 107 ? 132.311 107.488 143.392 1.00 40.16  ? 107 ALA A O   1 
ATOM   811  C CB  . ALA A 1 107 ? 134.598 108.113 145.469 1.00 40.16  ? 107 ALA A CB  1 
ATOM   812  N N   . CYS A 1 108 ? 132.515 109.731 143.465 1.00 39.24  ? 108 CYS A N   1 
ATOM   813  C CA  . CYS A 1 108 ? 131.790 109.961 142.228 1.00 39.24  ? 108 CYS A CA  1 
ATOM   814  C C   . CYS A 1 108 ? 132.603 110.772 141.237 1.00 39.24  ? 108 CYS A C   1 
ATOM   815  O O   . CYS A 1 108 ? 133.346 111.677 141.610 1.00 39.24  ? 108 CYS A O   1 
ATOM   816  C CB  . CYS A 1 108 ? 130.492 110.666 142.505 1.00 39.24  ? 108 CYS A CB  1 
ATOM   817  S SG  . CYS A 1 108 ? 129.350 109.677 143.445 1.00 39.24  ? 108 CYS A SG  1 
ATOM   818  N N   . ALA A 1 109 ? 132.431 110.434 139.963 1.00 38.20  ? 109 ALA A N   1 
ATOM   819  C CA  . ALA A 1 109 ? 133.102 111.094 138.845 1.00 38.20  ? 109 ALA A CA  1 
ATOM   820  C C   . ALA A 1 109 ? 132.066 111.811 138.001 1.00 38.20  ? 109 ALA A C   1 
ATOM   821  O O   . ALA A 1 109 ? 131.426 111.174 137.149 1.00 38.20  ? 109 ALA A O   1 
ATOM   822  C CB  . ALA A 1 109 ? 133.849 110.075 137.994 1.00 38.20  ? 109 ALA A CB  1 
ATOM   823  N N   . PRO A 1 110 ? 131.854 113.121 138.195 1.00 36.99  ? 110 PRO A N   1 
ATOM   824  C CA  . PRO A 1 110 ? 130.794 113.823 137.463 1.00 36.99  ? 110 PRO A CA  1 
ATOM   825  C C   . PRO A 1 110 ? 131.054 113.936 135.972 1.00 36.99  ? 110 PRO A C   1 
ATOM   826  O O   . PRO A 1 110 ? 130.169 113.667 135.160 1.00 36.99  ? 110 PRO A O   1 
ATOM   827  C CB  . PRO A 1 110 ? 130.788 115.207 138.116 1.00 36.99  ? 110 PRO A CB  1 
ATOM   828  C CG  . PRO A 1 110 ? 131.422 115.011 139.429 1.00 36.99  ? 110 PRO A CG  1 
ATOM   829  C CD  . PRO A 1 110 ? 132.445 113.975 139.232 1.00 36.99  ? 110 PRO A CD  1 
ATOM   830  N N   . LEU A 1 111 ? 132.286 114.273 135.605 1.00 37.80  ? 111 LEU A N   1 
ATOM   831  C CA  . LEU A 1 111 ? 132.674 114.554 134.232 1.00 37.80  ? 111 LEU A CA  1 
ATOM   832  C C   . LEU A 1 111 ? 132.920 113.289 133.403 1.00 37.80  ? 111 LEU A C   1 
ATOM   833  O O   . LEU A 1 111 ? 133.528 113.379 132.336 1.00 37.80  ? 111 LEU A O   1 
ATOM   834  C CB  . LEU A 1 111 ? 133.932 115.434 134.227 1.00 37.80  ? 111 LEU A CB  1 
ATOM   835  C CG  . LEU A 1 111 ? 133.932 116.969 134.365 1.00 37.80  ? 111 LEU A CG  1 
ATOM   836  C CD1 . LEU A 1 111 ? 133.234 117.649 133.210 1.00 37.80  ? 111 LEU A CD1 1 
ATOM   837  C CD2 . LEU A 1 111 ? 133.357 117.446 135.679 1.00 37.80  ? 111 LEU A CD2 1 
ATOM   838  N N   . TYR A 1 112 ? 132.484 112.127 133.880 1.00 38.66  ? 112 TYR A N   1 
ATOM   839  C CA  . TYR A 1 112 ? 132.532 110.882 133.131 1.00 38.66  ? 112 TYR A CA  1 
ATOM   840  C C   . TYR A 1 112 ? 131.637 110.948 131.906 1.00 38.66  ? 112 TYR A C   1 
ATOM   841  O O   . TYR A 1 112 ? 130.446 111.239 132.017 1.00 38.66  ? 112 TYR A O   1 
ATOM   842  C CB  . TYR A 1 112 ? 132.087 109.738 134.032 1.00 38.66  ? 112 TYR A CB  1 
ATOM   843  C CG  . TYR A 1 112 ? 131.806 108.423 133.349 1.00 38.66  ? 112 TYR A CG  1 
ATOM   844  C CD1 . TYR A 1 112 ? 132.821 107.547 133.024 1.00 38.66  ? 112 TYR A CD1 1 
ATOM   845  C CD2 . TYR A 1 112 ? 130.500 108.052 133.050 1.00 38.66  ? 112 TYR A CD2 1 
ATOM   846  C CE1 . TYR A 1 112 ? 132.539 106.346 132.420 1.00 38.66  ? 112 TYR A CE1 1 
ATOM   847  C CE2 . TYR A 1 112 ? 130.221 106.879 132.435 1.00 38.66  ? 112 TYR A CE2 1 
ATOM   848  C CZ  . TYR A 1 112 ? 131.232 106.023 132.139 1.00 38.66  ? 112 TYR A CZ  1 
ATOM   849  O OH  . TYR A 1 112 ? 130.911 104.840 131.536 1.00 38.66  ? 112 TYR A OH  1 
ATOM   850  N N   . HIS A 1 113 ? 132.197 110.624 130.748 1.00 39.42  ? 113 HIS A N   1 
ATOM   851  C CA  . HIS A 1 113 ? 131.462 110.530 129.500 1.00 39.42  ? 113 HIS A CA  1 
ATOM   852  C C   . HIS A 1 113 ? 131.329 109.075 129.091 1.00 39.42  ? 113 HIS A C   1 
ATOM   853  O O   . HIS A 1 113 ? 132.085 108.220 129.545 1.00 39.42  ? 113 HIS A O   1 
ATOM   854  C CB  . HIS A 1 113 ? 132.177 111.321 128.412 1.00 39.42  ? 113 HIS A CB  1 
ATOM   855  C CG  . HIS A 1 113 ? 132.207 112.790 128.671 1.00 39.42  ? 113 HIS A CG  1 
ATOM   856  N ND1 . HIS A 1 113 ? 133.108 113.377 129.527 1.00 39.42  ? 113 HIS A ND1 1 
ATOM   857  C CD2 . HIS A 1 113 ? 131.466 113.793 128.162 1.00 39.42  ? 113 HIS A CD2 1 
ATOM   858  C CE1 . HIS A 1 113 ? 132.900 114.678 129.556 1.00 39.42  ? 113 HIS A CE1 1 
ATOM   859  N NE2 . HIS A 1 113 ? 131.907 114.956 128.736 1.00 39.42  ? 113 HIS A NE2 1 
ATOM   860  N N   . TRP A 1 114 ? 130.363 108.789 128.225 1.00 40.70  ? 114 TRP A N   1 
ATOM   861  C CA  . TRP A 1 114 ? 130.239 107.434 127.726 1.00 40.70  ? 114 TRP A CA  1 
ATOM   862  C C   . TRP A 1 114 ? 129.626 107.472 126.336 1.00 40.70  ? 114 TRP A C   1 
ATOM   863  O O   . TRP A 1 114 ? 128.862 108.377 126.004 1.00 40.70  ? 114 TRP A O   1 
ATOM   864  C CB  . TRP A 1 114 ? 129.398 106.583 128.677 1.00 40.70  ? 114 TRP A CB  1 
ATOM   865  C CG  . TRP A 1 114 ? 127.936 106.664 128.487 1.00 40.70  ? 114 TRP A CG  1 
ATOM   866  C CD1 . TRP A 1 114 ? 127.169 107.773 128.575 1.00 40.70  ? 114 TRP A CD1 1 
ATOM   867  C CD2 . TRP A 1 114 ? 127.035 105.565 128.364 1.00 40.70  ? 114 TRP A CD2 1 
ATOM   868  N NE1 . TRP A 1 114 ? 125.850 107.450 128.411 1.00 40.70  ? 114 TRP A NE1 1 
ATOM   869  C CE2 . TRP A 1 114 ? 125.743 106.093 128.292 1.00 40.70  ? 114 TRP A CE2 1 
ATOM   870  C CE3 . TRP A 1 114 ? 127.204 104.187 128.262 1.00 40.70  ? 114 TRP A CE3 1 
ATOM   871  C CZ2 . TRP A 1 114 ? 124.633 105.299 128.124 1.00 40.70  ? 114 TRP A CZ2 1 
ATOM   872  C CZ3 . TRP A 1 114 ? 126.098 103.400 128.096 1.00 40.70  ? 114 TRP A CZ3 1 
ATOM   873  C CH2 . TRP A 1 114 ? 124.827 103.955 128.028 1.00 40.70  ? 114 TRP A CH2 1 
ATOM   874  N N   . ARG A 1 115 ? 129.994 106.492 125.522 1.00 43.70  ? 115 ARG A N   1 
ATOM   875  C CA  . ARG A 1 115 ? 129.346 106.228 124.248 1.00 43.70  ? 115 ARG A CA  1 
ATOM   876  C C   . ARG A 1 115 ? 128.086 105.449 124.569 1.00 43.70  ? 115 ARG A C   1 
ATOM   877  O O   . ARG A 1 115 ? 128.158 104.383 125.183 1.00 43.70  ? 115 ARG A O   1 
ATOM   878  C CB  . ARG A 1 115 ? 130.287 105.431 123.350 1.00 43.70  ? 115 ARG A CB  1 
ATOM   879  C CG  . ARG A 1 115 ? 129.877 105.190 121.908 1.00 43.70  ? 115 ARG A CG  1 
ATOM   880  C CD  . ARG A 1 115 ? 129.169 103.868 121.727 1.00 43.70  ? 115 ARG A CD  1 
ATOM   881  N NE  . ARG A 1 115 ? 128.955 103.543 120.331 1.00 43.70  ? 115 ARG A NE  1 
ATOM   882  C CZ  . ARG A 1 115 ? 127.966 102.779 119.902 1.00 43.70  ? 115 ARG A CZ  1 
ATOM   883  N NH1 . ARG A 1 115 ? 127.080 102.320 120.762 1.00 43.70  ? 115 ARG A NH1 1 
ATOM   884  N NH2 . ARG A 1 115 ? 127.829 102.523 118.613 1.00 43.70  ? 115 ARG A NH2 1 
ATOM   885  N N   . THR A 1 116 ? 126.936 105.961 124.158 1.00 43.76  ? 116 THR A N   1 
ATOM   886  C CA  . THR A 1 116 ? 125.701 105.313 124.566 1.00 43.76  ? 116 THR A CA  1 
ATOM   887  C C   . THR A 1 116 ? 125.438 104.049 123.757 1.00 43.76  ? 116 THR A C   1 
ATOM   888  O O   . THR A 1 116 ? 126.131 103.730 122.796 1.00 43.76  ? 116 THR A O   1 
ATOM   889  C CB  . THR A 1 116 ? 124.517 106.260 124.444 1.00 43.76  ? 116 THR A CB  1 
ATOM   890  O OG1 . THR A 1 116 ? 123.335 105.558 124.840 1.00 43.76  ? 116 THR A OG1 1 
ATOM   891  C CG2 . THR A 1 116 ? 124.344 106.725 123.020 1.00 43.76  ? 116 THR A CG2 1 
ATOM   892  N N   . GLU A 1 117 ? 124.400 103.324 124.158 1.00 45.39  ? 117 GLU A N   1 
ATOM   893  C CA  . GLU A 1 117 ? 124.120 102.035 123.540 1.00 45.39  ? 117 GLU A CA  1 
ATOM   894  C C   . GLU A 1 117 ? 123.507 102.161 122.152 1.00 45.39  ? 117 GLU A C   1 
ATOM   895  O O   . GLU A 1 117 ? 123.666 101.253 121.334 1.00 45.39  ? 117 GLU A O   1 
ATOM   896  C CB  . GLU A 1 117 ? 123.195 101.219 124.437 1.00 45.39  ? 117 GLU A CB  1 
ATOM   897  N N   . MET A 1 118 ? 122.813 103.257 121.858 1.00 49.61  ? 118 MET A N   1 
ATOM   898  C CA  . MET A 1 118 ? 122.108 103.371 120.586 1.00 49.61  ? 118 MET A CA  1 
ATOM   899  C C   . MET A 1 118 ? 122.917 104.045 119.488 1.00 49.61  ? 118 MET A C   1 
ATOM   900  O O   . MET A 1 118 ? 122.677 103.767 118.309 1.00 49.61  ? 118 MET A O   1 
ATOM   901  C CB  . MET A 1 118 ? 120.797 104.129 120.764 1.00 49.61  ? 118 MET A CB  1 
ATOM   902  C CG  . MET A 1 118 ? 119.750 103.372 121.537 1.00 49.61  ? 118 MET A CG  1 
ATOM   903  S SD  . MET A 1 118 ? 118.242 104.333 121.729 1.00 49.61  ? 118 MET A SD  1 
ATOM   904  C CE  . MET A 1 118 ? 117.633 104.323 120.045 1.00 49.61  ? 118 MET A CE  1 
ATOM   905  N N   . LYS A 1 119 ? 123.855 104.926 119.823 1.00 44.75  ? 119 LYS A N   1 
ATOM   906  C CA  . LYS A 1 119 ? 124.643 105.602 118.805 1.00 44.75  ? 119 LYS A CA  1 
ATOM   907  C C   . LYS A 1 119 ? 125.979 105.970 119.407 1.00 44.75  ? 119 LYS A C   1 
ATOM   908  O O   . LYS A 1 119 ? 126.252 105.679 120.568 1.00 44.75  ? 119 LYS A O   1 
ATOM   909  C CB  . LYS A 1 119 ? 123.935 106.847 118.277 1.00 44.75  ? 119 LYS A CB  1 
ATOM   910  N N   . GLN A 1 120 ? 126.823 106.610 118.616 1.00 45.36  ? 120 GLN A N   1 
ATOM   911  C CA  . GLN A 1 120 ? 128.089 107.066 119.157 1.00 45.36  ? 120 GLN A CA  1 
ATOM   912  C C   . GLN A 1 120 ? 127.942 108.485 119.678 1.00 45.36  ? 120 GLN A C   1 
ATOM   913  O O   . GLN A 1 120 ? 127.474 109.372 118.959 1.00 45.36  ? 120 GLN A O   1 
ATOM   914  C CB  . GLN A 1 120 ? 129.199 106.997 118.117 1.00 45.36  ? 120 GLN A CB  1 
ATOM   915  C CG  . GLN A 1 120 ? 129.650 105.606 117.802 1.00 45.36  ? 120 GLN A CG  1 
ATOM   916  C CD  . GLN A 1 120 ? 130.898 105.591 116.965 1.00 45.36  ? 120 GLN A CD  1 
ATOM   917  O OE1 . GLN A 1 120 ? 131.396 106.638 116.564 1.00 45.36  ? 120 GLN A OE1 1 
ATOM   918  N NE2 . GLN A 1 120 ? 131.425 104.405 116.705 1.00 45.36  ? 120 GLN A NE2 1 
ATOM   919  N N   . GLU A 1 121 ? 128.338 108.695 120.930 1.00 44.53  ? 121 GLU A N   1 
ATOM   920  C CA  . GLU A 1 121 ? 128.261 110.003 121.559 1.00 44.53  ? 121 GLU A CA  1 
ATOM   921  C C   . GLU A 1 121 ? 129.354 110.092 122.612 1.00 44.53  ? 121 GLU A C   1 
ATOM   922  O O   . GLU A 1 121 ? 130.119 109.149 122.820 1.00 44.53  ? 121 GLU A O   1 
ATOM   923  C CB  . GLU A 1 121 ? 126.879 110.238 122.163 1.00 44.53  ? 121 GLU A CB  1 
ATOM   924  N N   . ARG A 1 122 ? 129.449 111.257 123.250 1.00 43.16  ? 122 ARG A N   1 
ATOM   925  C CA  . ARG A 1 122 ? 130.264 111.468 124.450 1.00 43.16  ? 122 ARG A CA  1 
ATOM   926  C C   . ARG A 1 122 ? 129.390 112.298 125.383 1.00 43.16  ? 122 ARG A C   1 
ATOM   927  O O   . ARG A 1 122 ? 129.393 113.528 125.309 1.00 43.16  ? 122 ARG A O   1 
ATOM   928  C CB  . ARG A 1 122 ? 131.562 112.188 124.156 1.00 43.16  ? 122 ARG A CB  1 
ATOM   929  C CG  . ARG A 1 122 ? 132.532 111.473 123.301 1.00 43.16  ? 122 ARG A CG  1 
ATOM   930  C CD  . ARG A 1 122 ? 133.679 112.399 123.076 1.00 43.16  ? 122 ARG A CD  1 
ATOM   931  N NE  . ARG A 1 122 ? 134.396 112.648 124.311 1.00 43.16  ? 122 ARG A NE  1 
ATOM   932  C CZ  . ARG A 1 122 ? 135.522 112.042 124.639 1.00 43.16  ? 122 ARG A CZ  1 
ATOM   933  N NH1 . ARG A 1 122 ? 136.074 111.195 123.795 1.00 43.16  ? 122 ARG A NH1 1 
ATOM   934  N NH2 . ARG A 1 122 ? 136.116 112.315 125.784 1.00 43.16  ? 122 ARG A NH2 1 
ATOM   935  N N   . GLU A 1 123 ? 128.643 111.633 126.254 1.00 42.50  ? 123 GLU A N   1 
ATOM   936  C CA  . GLU A 1 123 ? 127.677 112.345 127.066 1.00 42.50  ? 123 GLU A CA  1 
ATOM   937  C C   . GLU A 1 123 ? 128.108 112.369 128.523 1.00 42.50  ? 123 GLU A C   1 
ATOM   938  O O   . GLU A 1 123 ? 128.258 111.299 129.128 1.00 42.50  ? 123 GLU A O   1 
ATOM   939  C CB  . GLU A 1 123 ? 126.309 111.706 126.915 1.00 42.50  ? 123 GLU A CB  1 
ATOM   940  C CG  . GLU A 1 123 ? 125.761 111.905 125.535 1.00 42.50  ? 123 GLU A CG  1 
ATOM   941  C CD  . GLU A 1 123 ? 124.358 111.403 125.389 1.00 42.50  ? 123 GLU A CD  1 
ATOM   942  O OE1 . GLU A 1 123 ? 123.850 110.764 126.328 1.00 42.50  ? 123 GLU A OE1 1 
ATOM   943  O OE2 . GLU A 1 123 ? 123.751 111.650 124.332 1.00 42.50  ? 123 GLU A OE2 1 
ATOM   944  N N   . PRO A 1 124 ? 128.301 113.562 129.130 1.00 40.80  ? 124 PRO A N   1 
ATOM   945  C CA  . PRO A 1 124 ? 128.781 113.633 130.515 1.00 40.80  ? 124 PRO A CA  1 
ATOM   946  C C   . PRO A 1 124 ? 127.739 113.179 131.512 1.00 40.80  ? 124 PRO A C   1 
ATOM   947  O O   . PRO A 1 124 ? 127.005 113.988 132.079 1.00 40.80  ? 124 PRO A O   1 
ATOM   948  C CB  . PRO A 1 124 ? 129.119 115.115 130.692 1.00 40.80  ? 124 PRO A CB  1 
ATOM   949  C CG  . PRO A 1 124 ? 128.307 115.807 129.688 1.00 40.80  ? 124 PRO A CG  1 
ATOM   950  C CD  . PRO A 1 124 ? 128.225 114.895 128.520 1.00 40.80  ? 124 PRO A CD  1 
ATOM   951  N N   . VAL A 1 125 ? 127.665 111.867 131.716 1.00 39.63  ? 125 VAL A N   1 
ATOM   952  C CA  . VAL A 1 125 ? 126.552 111.276 132.440 1.00 39.63  ? 125 VAL A CA  1 
ATOM   953  C C   . VAL A 1 125 ? 126.907 110.970 133.892 1.00 39.63  ? 125 VAL A C   1 
ATOM   954  O O   . VAL A 1 125 ? 126.006 110.871 134.733 1.00 39.63  ? 125 VAL A O   1 
ATOM   955  C CB  . VAL A 1 125 ? 126.078 110.035 131.662 1.00 39.63  ? 125 VAL A CB  1 
ATOM   956  C CG1 . VAL A 1 125 ? 127.002 108.869 131.877 1.00 39.63  ? 125 VAL A CG1 1 
ATOM   957  C CG2 . VAL A 1 125 ? 124.679 109.700 131.978 1.00 39.63  ? 125 VAL A CG2 1 
ATOM   958  N N   . GLY A 1 126 ? 128.188 110.871 134.224 1.00 39.39  ? 126 GLY A N   1 
ATOM   959  C CA  . GLY A 1 126 ? 128.597 110.617 135.586 1.00 39.39  ? 126 GLY A CA  1 
ATOM   960  C C   . GLY A 1 126 ? 128.438 109.185 136.051 1.00 39.39  ? 126 GLY A C   1 
ATOM   961  O O   . GLY A 1 126 ? 127.476 108.504 135.696 1.00 39.39  ? 126 GLY A O   1 
ATOM   962  N N   . THR A 1 127 ? 129.388 108.718 136.857 1.00 41.10  ? 127 THR A N   1 
ATOM   963  C CA  . THR A 1 127 ? 129.284 107.457 137.577 1.00 41.10  ? 127 THR A CA  1 
ATOM   964  C C   . THR A 1 127 ? 129.660 107.682 139.028 1.00 41.10  ? 127 THR A C   1 
ATOM   965  O O   . THR A 1 127 ? 130.155 108.746 139.407 1.00 41.10  ? 127 THR A O   1 
ATOM   966  C CB  . THR A 1 127 ? 130.194 106.362 137.015 1.00 41.10  ? 127 THR A CB  1 
ATOM   967  O OG1 . THR A 1 127 ? 131.526 106.867 136.863 1.00 41.10  ? 127 THR A OG1 1 
ATOM   968  C CG2 . THR A 1 127 ? 129.687 105.836 135.737 1.00 41.10  ? 127 THR A CG2 1 
ATOM   969  N N   . CYS A 1 128 ? 129.438 106.651 139.837 1.00 40.45  ? 128 CYS A N   1 
ATOM   970  C CA  . CYS A 1 128 ? 129.879 106.626 141.218 1.00 40.45  ? 128 CYS A CA  1 
ATOM   971  C C   . CYS A 1 128 ? 130.367 105.225 141.537 1.00 40.45  ? 128 CYS A C   1 
ATOM   972  O O   . CYS A 1 128 ? 129.938 104.248 140.925 1.00 40.45  ? 128 CYS A O   1 
ATOM   973  C CB  . CYS A 1 128 ? 128.766 107.032 142.184 1.00 40.45  ? 128 CYS A CB  1 
ATOM   974  S SG  . CYS A 1 128 ? 128.248 108.729 142.041 1.00 40.45  ? 128 CYS A SG  1 
ATOM   975  N N   . PHE A 1 129 ? 131.281 105.145 142.500 1.00 41.59  ? 129 PHE A N   1 
ATOM   976  C CA  . PHE A 1 129 ? 131.838 103.891 142.988 1.00 41.59  ? 129 PHE A CA  1 
ATOM   977  C C   . PHE A 1 129 ? 131.585 103.763 144.479 1.00 41.59  ? 129 PHE A C   1 
ATOM   978  O O   . PHE A 1 129 ? 131.954 104.651 145.250 1.00 41.59  ? 129 PHE A O   1 
ATOM   979  C CB  . PHE A 1 129 ? 133.336 103.808 142.704 1.00 41.59  ? 129 PHE A CB  1 
ATOM   980  C CG  . PHE A 1 129 ? 133.666 103.465 141.284 1.00 41.59  ? 129 PHE A CG  1 
ATOM   981  C CD1 . PHE A 1 129 ? 132.778 102.754 140.499 1.00 41.59  ? 129 PHE A CD1 1 
ATOM   982  C CD2 . PHE A 1 129 ? 134.846 103.888 140.719 1.00 41.59  ? 129 PHE A CD2 1 
ATOM   983  C CE1 . PHE A 1 129 ? 133.078 102.450 139.194 1.00 41.59  ? 129 PHE A CE1 1 
ATOM   984  C CE2 . PHE A 1 129 ? 135.134 103.590 139.409 1.00 41.59  ? 129 PHE A CE2 1 
ATOM   985  C CZ  . PHE A 1 129 ? 134.251 102.864 138.652 1.00 41.59  ? 129 PHE A CZ  1 
ATOM   986  N N   . LEU A 1 130 ? 130.978 102.649 144.881 1.00 40.96  ? 130 LEU A N   1 
ATOM   987  C CA  . LEU A 1 130 ? 130.617 102.375 146.267 1.00 40.96  ? 130 LEU A CA  1 
ATOM   988  C C   . LEU A 1 130 ? 131.482 101.240 146.786 1.00 40.96  ? 130 LEU A C   1 
ATOM   989  O O   . LEU A 1 130 ? 131.314 100.093 146.371 1.00 40.96  ? 130 LEU A O   1 
ATOM   990  C CB  . LEU A 1 130 ? 129.141 102.015 146.374 1.00 40.96  ? 130 LEU A CB  1 
ATOM   991  C CG  . LEU A 1 130 ? 128.537 101.664 147.726 1.00 40.96  ? 130 LEU A CG  1 
ATOM   992  C CD1 . LEU A 1 130 ? 128.610 102.825 148.679 1.00 40.96  ? 130 LEU A CD1 1 
ATOM   993  C CD2 . LEU A 1 130 ? 127.113 101.253 147.522 1.00 40.96  ? 130 LEU A CD2 1 
ATOM   994  N N   . GLN A 1 131 ? 132.390 101.552 147.703 1.00 43.49  ? 131 GLN A N   1 
ATOM   995  C CA  . GLN A 1 131 ? 133.234 100.561 148.358 1.00 43.49  ? 131 GLN A CA  1 
ATOM   996  C C   . GLN A 1 131 ? 132.635 100.226 149.712 1.00 43.49  ? 131 GLN A C   1 
ATOM   997  O O   . GLN A 1 131 ? 132.874 100.936 150.686 1.00 43.49  ? 131 GLN A O   1 
ATOM   998  C CB  . GLN A 1 131 ? 134.651 101.084 148.540 1.00 43.49  ? 131 GLN A CB  1 
ATOM   999  C CG  . GLN A 1 131 ? 135.584 100.077 149.157 1.00 43.49  ? 131 GLN A CG  1 
ATOM   1000 C CD  . GLN A 1 131 ? 136.938 100.656 149.431 1.00 43.49  ? 131 GLN A CD  1 
ATOM   1001 O OE1 . GLN A 1 131 ? 137.176 101.830 149.182 1.00 43.49  ? 131 GLN A OE1 1 
ATOM   1002 N NE2 . GLN A 1 131 ? 137.835 99.843  149.967 1.00 43.49  ? 131 GLN A NE2 1 
ATOM   1003 N N   . ASP A 1 132 ? 131.881 99.141  149.784 1.00 48.10  ? 132 ASP A N   1 
ATOM   1004 C CA  . ASP A 1 132 ? 131.336 98.649  151.044 1.00 48.10  ? 132 ASP A CA  1 
ATOM   1005 C C   . ASP A 1 132 ? 132.289 97.591  151.579 1.00 48.10  ? 132 ASP A C   1 
ATOM   1006 O O   . ASP A 1 132 ? 132.069 96.393  151.378 1.00 48.10  ? 132 ASP A O   1 
ATOM   1007 C CB  . ASP A 1 132 ? 129.939 98.073  150.851 1.00 48.10  ? 132 ASP A CB  1 
ATOM   1008 C CG  . ASP A 1 132 ? 129.225 97.806  152.163 1.00 48.10  ? 132 ASP A CG  1 
ATOM   1009 O OD1 . ASP A 1 132 ? 129.784 98.104  153.239 1.00 48.10  ? 132 ASP A OD1 1 
ATOM   1010 O OD2 . ASP A 1 132 ? 128.092 97.284  152.119 1.00 48.10  ? 132 ASP A OD2 1 
ATOM   1011 N N   . GLY A 1 133 ? 133.329 98.028  152.273 1.00 49.27  ? 133 GLY A N   1 
ATOM   1012 C CA  . GLY A 1 133 ? 134.306 97.102  152.799 1.00 49.27  ? 133 GLY A CA  1 
ATOM   1013 C C   . GLY A 1 133 ? 135.239 96.580  151.731 1.00 49.27  ? 133 GLY A C   1 
ATOM   1014 O O   . GLY A 1 133 ? 136.057 97.330  151.194 1.00 49.27  ? 133 GLY A O   1 
ATOM   1015 N N   . THR A 1 134 ? 135.124 95.293  151.409 1.00 50.96  ? 134 THR A N   1 
ATOM   1016 C CA  . THR A 1 134 ? 136.003 94.656  150.438 1.00 50.96  ? 134 THR A CA  1 
ATOM   1017 C C   . THR A 1 134 ? 135.385 94.532  149.052 1.00 50.96  ? 134 THR A C   1 
ATOM   1018 O O   . THR A 1 134 ? 136.067 94.079  148.128 1.00 50.96  ? 134 THR A O   1 
ATOM   1019 C CB  . THR A 1 134 ? 136.415 93.263  150.929 1.00 50.96  ? 134 THR A CB  1 
ATOM   1020 N N   . LYS A 1 135 ? 134.126 94.916  148.882 1.00 47.76  ? 135 LYS A N   1 
ATOM   1021 C CA  . LYS A 1 135 ? 133.433 94.807  147.611 1.00 47.76  ? 135 LYS A CA  1 
ATOM   1022 C C   . LYS A 1 135 ? 133.182 96.200  147.067 1.00 47.76  ? 135 LYS A C   1 
ATOM   1023 O O   . LYS A 1 135 ? 132.547 97.021  147.734 1.00 47.76  ? 135 LYS A O   1 
ATOM   1024 C CB  . LYS A 1 135 ? 132.116 94.062  147.777 1.00 47.76  ? 135 LYS A CB  1 
ATOM   1025 C CG  . LYS A 1 135 ? 131.382 93.838  146.486 1.00 47.76  ? 135 LYS A CG  1 
ATOM   1026 C CD  . LYS A 1 135 ? 130.134 93.016  146.714 1.00 47.76  ? 135 LYS A CD  1 
ATOM   1027 C CE  . LYS A 1 135 ? 129.402 92.758  145.410 1.00 47.76  ? 135 LYS A CE  1 
ATOM   1028 N NZ  . LYS A 1 135 ? 128.178 91.939  145.612 1.00 47.76  ? 135 LYS A NZ  1 
ATOM   1029 N N   . THR A 1 136 ? 133.670 96.464  145.863 1.00 43.76  ? 136 THR A N   1 
ATOM   1030 C CA  . THR A 1 136 ? 133.451 97.731  145.189 1.00 43.76  ? 136 THR A CA  1 
ATOM   1031 C C   . THR A 1 136 ? 132.492 97.501  144.038 1.00 43.76  ? 136 THR A C   1 
ATOM   1032 O O   . THR A 1 136 ? 132.723 96.623  143.206 1.00 43.76  ? 136 THR A O   1 
ATOM   1033 C CB  . THR A 1 136 ? 134.762 98.322  144.674 1.00 43.76  ? 136 THR A CB  1 
ATOM   1034 O OG1 . THR A 1 136 ? 135.667 98.506  145.767 1.00 43.76  ? 136 THR A OG1 1 
ATOM   1035 C CG2 . THR A 1 136 ? 134.521 99.659  144.022 1.00 43.76  ? 136 THR A CG2 1 
ATOM   1036 N N   . VAL A 1 137 ? 131.413 98.272  144.003 1.00 41.14  ? 137 VAL A N   1 
ATOM   1037 C CA  . VAL A 1 137 ? 130.440 98.203  142.930 1.00 41.14  ? 137 VAL A CA  1 
ATOM   1038 C C   . VAL A 1 137 ? 130.434 99.540  142.207 1.00 41.14  ? 137 VAL A C   1 
ATOM   1039 O O   . VAL A 1 137 ? 131.023 100.515 142.660 1.00 41.14  ? 137 VAL A O   1 
ATOM   1040 C CB  . VAL A 1 137 ? 129.038 97.845  143.442 1.00 41.14  ? 137 VAL A CB  1 
ATOM   1041 C CG1 . VAL A 1 137 ? 129.069 96.516  144.139 1.00 41.14  ? 137 VAL A CG1 1 
ATOM   1042 C CG2 . VAL A 1 137 ? 128.542 98.901  144.371 1.00 41.14  ? 137 VAL A CG2 1 
ATOM   1043 N N   . GLU A 1 138 ? 129.763 99.570  141.064 1.00 41.23  ? 138 GLU A N   1 
ATOM   1044 C CA  . GLU A 1 138 ? 129.624 100.775 140.266 1.00 41.23  ? 138 GLU A CA  1 
ATOM   1045 C C   . GLU A 1 138 ? 128.175 101.227 140.275 1.00 41.23  ? 138 GLU A C   1 
ATOM   1046 O O   . GLU A 1 138 ? 127.265 100.423 140.071 1.00 41.23  ? 138 GLU A O   1 
ATOM   1047 C CB  . GLU A 1 138 ? 130.081 100.543 138.833 1.00 41.23  ? 138 GLU A CB  1 
ATOM   1048 N N   . TYR A 1 139 ? 127.967 102.517 140.516 1.00 43.81  ? 139 TYR A N   1 
ATOM   1049 C CA  . TYR A 1 139 ? 126.635 103.100 140.624 1.00 43.81  ? 139 TYR A CA  1 
ATOM   1050 C C   . TYR A 1 139 ? 126.512 104.214 139.599 1.00 43.81  ? 139 TYR A C   1 
ATOM   1051 O O   . TYR A 1 139 ? 127.202 105.231 139.700 1.00 43.81  ? 139 TYR A O   1 
ATOM   1052 C CB  . TYR A 1 139 ? 126.384 103.618 142.035 1.00 43.81  ? 139 TYR A CB  1 
ATOM   1053 C CG  . TYR A 1 139 ? 125.035 104.245 142.245 1.00 43.81  ? 139 TYR A CG  1 
ATOM   1054 C CD1 . TYR A 1 139 ? 123.882 103.491 142.172 1.00 43.81  ? 139 TYR A CD1 1 
ATOM   1055 C CD2 . TYR A 1 139 ? 124.921 105.579 142.581 1.00 43.81  ? 139 TYR A CD2 1 
ATOM   1056 C CE1 . TYR A 1 139 ? 122.653 104.056 142.385 1.00 43.81  ? 139 TYR A CE1 1 
ATOM   1057 C CE2 . TYR A 1 139 ? 123.693 106.151 142.800 1.00 43.81  ? 139 TYR A CE2 1 
ATOM   1058 C CZ  . TYR A 1 139 ? 122.567 105.383 142.702 1.00 43.81  ? 139 TYR A CZ  1 
ATOM   1059 O OH  . TYR A 1 139 ? 121.343 105.956 142.922 1.00 43.81  ? 139 TYR A OH  1 
ATOM   1060 N N   . ALA A 1 140 ? 125.643 104.021 138.615 1.00 42.45  ? 140 ALA A N   1 
ATOM   1061 C CA  . ALA A 1 140 ? 125.476 104.968 137.517 1.00 42.45  ? 140 ALA A CA  1 
ATOM   1062 C C   . ALA A 1 140 ? 124.020 105.020 137.114 1.00 42.45  ? 140 ALA A C   1 
ATOM   1063 O O   . ALA A 1 140 ? 123.617 104.412 136.118 1.00 42.45  ? 140 ALA A O   1 
ATOM   1064 C CB  . ALA A 1 140 ? 126.331 104.568 136.325 1.00 42.45  ? 140 ALA A CB  1 
ATOM   1065 N N   . PRO A 1 141 ? 123.191 105.748 137.857 1.00 42.67  ? 141 PRO A N   1 
ATOM   1066 C CA  . PRO A 1 141 ? 121.764 105.722 137.544 1.00 42.67  ? 141 PRO A CA  1 
ATOM   1067 C C   . PRO A 1 141 ? 121.385 106.632 136.396 1.00 42.67  ? 141 PRO A C   1 
ATOM   1068 O O   . PRO A 1 141 ? 120.363 106.386 135.745 1.00 42.67  ? 141 PRO A O   1 
ATOM   1069 C CB  . PRO A 1 141 ? 121.122 106.165 138.856 1.00 42.67  ? 141 PRO A CB  1 
ATOM   1070 C CG  . PRO A 1 141 ? 122.106 107.030 139.438 1.00 42.67  ? 141 PRO A CG  1 
ATOM   1071 C CD  . PRO A 1 141 ? 123.454 106.527 139.070 1.00 42.67  ? 141 PRO A CD  1 
ATOM   1072 N N   . CYS A 1 142 ? 122.167 107.681 136.128 1.00 44.34  ? 142 CYS A N   1 
ATOM   1073 C CA  . CYS A 1 142 ? 121.902 108.518 134.968 1.00 44.34  ? 142 CYS A CA  1 
ATOM   1074 C C   . CYS A 1 142 ? 122.305 107.825 133.676 1.00 44.34  ? 142 CYS A C   1 
ATOM   1075 O O   . CYS A 1 142 ? 121.783 108.175 132.614 1.00 44.34  ? 142 CYS A O   1 
ATOM   1076 C CB  . CYS A 1 142 ? 122.619 109.866 135.105 1.00 44.34  ? 142 CYS A CB  1 
ATOM   1077 S SG  . CYS A 1 142 ? 122.033 110.852 136.509 1.00 44.34  ? 142 CYS A SG  1 
ATOM   1078 N N   . ARG A 1 143 ? 123.214 106.849 133.745 1.00 41.60  ? 143 ARG A N   1 
ATOM   1079 C CA  . ARG A 1 143 ? 123.668 106.091 132.578 1.00 41.60  ? 143 ARG A CA  1 
ATOM   1080 C C   . ARG A 1 143 ? 122.575 105.100 132.200 1.00 41.60  ? 143 ARG A C   1 
ATOM   1081 O O   . ARG A 1 143 ? 122.566 103.938 132.604 1.00 41.60  ? 143 ARG A O   1 
ATOM   1082 C CB  . ARG A 1 143 ? 124.991 105.404 132.880 1.00 41.60  ? 143 ARG A CB  1 
ATOM   1083 C CG  . ARG A 1 143 ? 125.633 104.696 131.715 1.00 41.60  ? 143 ARG A CG  1 
ATOM   1084 C CD  . ARG A 1 143 ? 127.025 104.206 132.074 1.00 41.60  ? 143 ARG A CD  1 
ATOM   1085 N NE  . ARG A 1 143 ? 127.026 103.141 133.065 1.00 41.60  ? 143 ARG A NE  1 
ATOM   1086 C CZ  . ARG A 1 143 ? 128.116 102.718 133.688 1.00 41.60  ? 143 ARG A CZ  1 
ATOM   1087 N NH1 . ARG A 1 143 ? 129.281 103.278 133.431 1.00 41.60  ? 143 ARG A NH1 1 
ATOM   1088 N NH2 . ARG A 1 143 ? 128.041 101.745 134.574 1.00 41.60  ? 143 ARG A NH2 1 
ATOM   1089 N N   . SER A 1 144 ? 121.627 105.582 131.407 1.00 42.59  ? 144 SER A N   1 
ATOM   1090 C CA  . SER A 1 144 ? 120.420 104.827 131.118 1.00 42.59  ? 144 SER A CA  1 
ATOM   1091 C C   . SER A 1 144 ? 120.038 104.934 129.653 1.00 42.59  ? 144 SER A C   1 
ATOM   1092 O O   . SER A 1 144 ? 120.837 105.378 128.831 1.00 42.59  ? 144 SER A O   1 
ATOM   1093 C CB  . SER A 1 144 ? 119.276 105.316 131.994 1.00 42.59  ? 144 SER A CB  1 
ATOM   1094 O OG  . SER A 1 144 ? 118.941 106.651 131.674 1.00 42.59  ? 144 SER A OG  1 
ATOM   1095 N N   . GLN A 1 145 ? 118.822 104.528 129.317 1.00 43.81  ? 145 GLN A N   1 
ATOM   1096 C CA  . GLN A 1 145 ? 118.378 104.509 127.933 1.00 43.81  ? 145 GLN A CA  1 
ATOM   1097 C C   . GLN A 1 145 ? 117.789 105.832 127.463 1.00 43.81  ? 145 GLN A C   1 
ATOM   1098 O O   . GLN A 1 145 ? 117.577 105.992 126.257 1.00 43.81  ? 145 GLN A O   1 
ATOM   1099 C CB  . GLN A 1 145 ? 117.351 103.397 127.733 1.00 43.81  ? 145 GLN A CB  1 
ATOM   1100 N N   . ASP A 1 146 ? 117.503 106.770 128.365 1.00 44.39  ? 146 ASP A N   1 
ATOM   1101 C CA  . ASP A 1 146 ? 117.072 108.118 127.990 1.00 44.39  ? 146 ASP A CA  1 
ATOM   1102 C C   . ASP A 1 146 ? 118.326 108.937 127.721 1.00 44.39  ? 146 ASP A C   1 
ATOM   1103 O O   . ASP A 1 146 ? 119.041 109.316 128.649 1.00 44.39  ? 146 ASP A O   1 
ATOM   1104 C CB  . ASP A 1 146 ? 116.222 108.738 129.089 1.00 44.39  ? 146 ASP A CB  1 
ATOM   1105 N N   . ILE A 1 147 ? 118.611 109.197 126.447 1.00 45.41  ? 147 ILE A N   1 
ATOM   1106 C CA  . ILE A 1 147 ? 119.939 109.660 126.061 1.00 45.41  ? 147 ILE A CA  1 
ATOM   1107 C C   . ILE A 1 147 ? 119.944 110.917 125.194 1.00 45.41  ? 147 ILE A C   1 
ATOM   1108 O O   . ILE A 1 147 ? 119.996 110.837 123.960 1.00 45.41  ? 147 ILE A O   1 
ATOM   1109 C CB  . ILE A 1 147 ? 120.690 108.507 125.368 1.00 45.41  ? 147 ILE A CB  1 
ATOM   1110 C CG1 . ILE A 1 147 ? 119.771 107.746 124.399 1.00 45.41  ? 147 ILE A CG1 1 
ATOM   1111 C CG2 . ILE A 1 147 ? 121.295 107.579 126.395 1.00 45.41  ? 147 ILE A CG2 1 
ATOM   1112 C CD1 . ILE A 1 147 ? 120.500 106.817 123.468 1.00 45.41  ? 147 ILE A CD1 1 
ATOM   1113 N N   . ASP A 1 148 ? 119.979 112.085 125.844 1.00 45.10  ? 148 ASP A N   1 
ATOM   1114 C CA  . ASP A 1 148 ? 120.184 113.388 125.211 1.00 45.10  ? 148 ASP A CA  1 
ATOM   1115 C C   . ASP A 1 148 ? 120.361 114.455 126.279 1.00 45.10  ? 148 ASP A C   1 
ATOM   1116 O O   . ASP A 1 148 ? 120.435 114.145 127.468 1.00 45.10  ? 148 ASP A O   1 
ATOM   1117 C CB  . ASP A 1 148 ? 119.012 113.793 124.307 1.00 45.10  ? 148 ASP A CB  1 
ATOM   1118 N N   . ALA A 1 149 ? 120.404 115.721 125.867 1.00 42.93  ? 149 ALA A N   1 
ATOM   1119 C CA  . ALA A 1 149 ? 120.096 116.792 126.803 1.00 42.93  ? 149 ALA A CA  1 
ATOM   1120 C C   . ALA A 1 149 ? 118.638 116.737 127.214 1.00 42.93  ? 149 ALA A C   1 
ATOM   1121 O O   . ALA A 1 149 ? 118.282 117.182 128.307 1.00 42.93  ? 149 ALA A O   1 
ATOM   1122 C CB  . ALA A 1 149 ? 120.407 118.147 126.180 1.00 42.93  ? 149 ALA A CB  1 
ATOM   1123 N N   . ASP A 1 150 ? 117.785 116.213 126.339 1.00 43.90  ? 150 ASP A N   1 
ATOM   1124 C CA  . ASP A 1 150 ? 116.382 116.022 126.651 1.00 43.90  ? 150 ASP A CA  1 
ATOM   1125 C C   . ASP A 1 150 ? 116.196 115.008 127.765 1.00 43.90  ? 150 ASP A C   1 
ATOM   1126 O O   . ASP A 1 150 ? 115.364 115.212 128.653 1.00 43.90  ? 150 ASP A O   1 
ATOM   1127 C CB  . ASP A 1 150 ? 115.654 115.579 125.388 1.00 43.90  ? 150 ASP A CB  1 
ATOM   1128 C CG  . ASP A 1 150 ? 114.152 115.725 125.484 1.00 43.90  ? 150 ASP A CG  1 
ATOM   1129 O OD1 . ASP A 1 150 ? 113.641 116.202 126.518 1.00 43.90  ? 150 ASP A OD1 1 
ATOM   1130 O OD2 . ASP A 1 150 ? 113.471 115.357 124.505 1.00 43.90  ? 150 ASP A OD2 1 
ATOM   1131 N N   . GLY A 1 151 ? 116.962 113.926 127.750 1.00 43.29  ? 151 GLY A N   1 
ATOM   1132 C CA  . GLY A 1 151 ? 116.866 112.926 128.792 1.00 43.29  ? 151 GLY A CA  1 
ATOM   1133 C C   . GLY A 1 151 ? 117.956 113.070 129.826 1.00 43.29  ? 151 GLY A C   1 
ATOM   1134 O O   . GLY A 1 151 ? 118.353 114.185 130.163 1.00 43.29  ? 151 GLY A O   1 
ATOM   1135 N N   . GLN A 1 152 ? 118.459 111.951 130.333 1.00 43.94  ? 152 GLN A N   1 
ATOM   1136 C CA  . GLN A 1 152 ? 119.455 111.953 131.393 1.00 43.94  ? 152 GLN A CA  1 
ATOM   1137 C C   . GLN A 1 152 ? 120.874 111.877 130.856 1.00 43.94  ? 152 GLN A C   1 
ATOM   1138 O O   . GLN A 1 152 ? 121.770 111.416 131.563 1.00 43.94  ? 152 GLN A O   1 
ATOM   1139 C CB  . GLN A 1 152 ? 119.205 110.787 132.344 1.00 43.94  ? 152 GLN A CB  1 
ATOM   1140 C CG  . GLN A 1 152 ? 117.887 110.839 133.064 1.00 43.94  ? 152 GLN A CG  1 
ATOM   1141 C CD  . GLN A 1 152 ? 117.654 109.610 133.906 1.00 43.94  ? 152 GLN A CD  1 
ATOM   1142 O OE1 . GLN A 1 152 ? 118.460 108.684 133.903 1.00 43.94  ? 152 GLN A OE1 1 
ATOM   1143 N NE2 . GLN A 1 152 ? 116.545 109.589 134.630 1.00 43.94  ? 152 GLN A NE2 1 
ATOM   1144 N N   . GLY A 1 153 ? 121.096 112.301 129.616 1.00 41.48  ? 153 GLY A N   1 
ATOM   1145 C CA  . GLY A 1 153 ? 122.383 112.059 128.992 1.00 41.48  ? 153 GLY A CA  1 
ATOM   1146 C C   . GLY A 1 153 ? 123.457 113.001 129.478 1.00 41.48  ? 153 GLY A C   1 
ATOM   1147 O O   . GLY A 1 153 ? 124.614 112.614 129.626 1.00 41.48  ? 153 GLY A O   1 
ATOM   1148 N N   . PHE A 1 154 ? 123.096 114.248 129.733 1.00 42.83  ? 154 PHE A N   1 
ATOM   1149 C CA  . PHE A 1 154 ? 124.051 115.214 130.253 1.00 42.83  ? 154 PHE A CA  1 
ATOM   1150 C C   . PHE A 1 154 ? 123.882 115.387 131.754 1.00 42.83  ? 154 PHE A C   1 
ATOM   1151 O O   . PHE A 1 154 ? 124.082 116.489 132.274 1.00 42.83  ? 154 PHE A O   1 
ATOM   1152 C CB  . PHE A 1 154 ? 123.911 116.552 129.524 1.00 42.83  ? 154 PHE A CB  1 
ATOM   1153 C CG  . PHE A 1 154 ? 124.217 116.485 128.036 1.00 42.83  ? 154 PHE A CG  1 
ATOM   1154 C CD1 . PHE A 1 154 ? 124.940 115.446 127.488 1.00 42.83  ? 154 PHE A CD1 1 
ATOM   1155 C CD2 . PHE A 1 154 ? 123.743 117.452 127.191 1.00 42.83  ? 154 PHE A CD2 1 
ATOM   1156 C CE1 . PHE A 1 154 ? 125.194 115.391 126.145 1.00 42.83  ? 154 PHE A CE1 1 
ATOM   1157 C CE2 . PHE A 1 154 ? 123.990 117.385 125.845 1.00 42.83  ? 154 PHE A CE2 1 
ATOM   1158 C CZ  . PHE A 1 154 ? 124.718 116.357 125.327 1.00 42.83  ? 154 PHE A CZ  1 
ATOM   1159 N N   . CYS A 1 155 ? 123.510 114.293 132.439 1.00 42.03  ? 155 CYS A N   1 
ATOM   1160 C CA  . CYS A 1 155 ? 123.074 114.328 133.831 1.00 42.03  ? 155 CYS A CA  1 
ATOM   1161 C C   . CYS A 1 155 ? 124.177 114.807 134.738 1.00 42.03  ? 155 CYS A C   1 
ATOM   1162 O O   . CYS A 1 155 ? 123.944 115.650 135.607 1.00 42.03  ? 155 CYS A O   1 
ATOM   1163 C CB  . CYS A 1 155 ? 122.625 112.932 134.271 1.00 42.03  ? 155 CYS A CB  1 
ATOM   1164 S SG  . CYS A 1 155 ? 121.959 112.812 135.948 1.00 42.03  ? 155 CYS A SG  1 
ATOM   1165 N N   . GLN A 1 156 ? 125.379 114.291 134.519 1.00 38.64  ? 156 GLN A N   1 
ATOM   1166 C CA  . GLN A 1 156 ? 126.575 114.591 135.287 1.00 38.64  ? 156 GLN A CA  1 
ATOM   1167 C C   . GLN A 1 156 ? 126.323 114.291 136.762 1.00 38.64  ? 156 GLN A C   1 
ATOM   1168 O O   . GLN A 1 156 ? 126.586 115.094 137.656 1.00 38.64  ? 156 GLN A O   1 
ATOM   1169 C CB  . GLN A 1 156 ? 127.024 116.025 135.001 1.00 38.64  ? 156 GLN A CB  1 
ATOM   1170 C CG  . GLN A 1 156 ? 128.422 116.375 135.339 1.00 38.64  ? 156 GLN A CG  1 
ATOM   1171 C CD  . GLN A 1 156 ? 128.870 117.581 134.599 1.00 38.64  ? 156 GLN A CD  1 
ATOM   1172 O OE1 . GLN A 1 156 ? 128.139 118.121 133.784 1.00 38.64  ? 156 GLN A OE1 1 
ATOM   1173 N NE2 . GLN A 1 156 ? 130.077 118.015 134.869 1.00 38.64  ? 156 GLN A NE2 1 
ATOM   1174 N N   . GLY A 1 157 ? 125.758 113.106 136.989 1.00 38.35  ? 157 GLY A N   1 
ATOM   1175 C CA  . GLY A 1 157 ? 125.373 112.709 138.323 1.00 38.35  ? 157 GLY A CA  1 
ATOM   1176 C C   . GLY A 1 157 ? 126.567 112.325 139.169 1.00 38.35  ? 157 GLY A C   1 
ATOM   1177 O O   . GLY A 1 157 ? 127.629 111.964 138.673 1.00 38.35  ? 157 GLY A O   1 
ATOM   1178 N N   . GLY A 1 158 ? 126.379 112.396 140.472 1.00 38.03  ? 158 GLY A N   1 
ATOM   1179 C CA  . GLY A 1 158 ? 127.498 112.351 141.369 1.00 38.03  ? 158 GLY A CA  1 
ATOM   1180 C C   . GLY A 1 158 ? 128.145 113.685 141.591 1.00 38.03  ? 158 GLY A C   1 
ATOM   1181 O O   . GLY A 1 158 ? 129.247 113.741 142.146 1.00 38.03  ? 158 GLY A O   1 
ATOM   1182 N N   . PHE A 1 159 ? 127.495 114.761 141.168 1.00 37.90  ? 159 PHE A N   1 
ATOM   1183 C CA  . PHE A 1 159 ? 128.035 116.093 141.373 1.00 37.90  ? 159 PHE A CA  1 
ATOM   1184 C C   . PHE A 1 159 ? 127.964 116.467 142.843 1.00 37.90  ? 159 PHE A C   1 
ATOM   1185 O O   . PHE A 1 159 ? 128.814 117.204 143.353 1.00 37.90  ? 159 PHE A O   1 
ATOM   1186 C CB  . PHE A 1 159 ? 127.245 117.070 140.514 1.00 37.90  ? 159 PHE A CB  1 
ATOM   1187 C CG  . PHE A 1 159 ? 127.867 118.415 140.376 1.00 37.90  ? 159 PHE A CG  1 
ATOM   1188 C CD1 . PHE A 1 159 ? 128.920 118.614 139.510 1.00 37.90  ? 159 PHE A CD1 1 
ATOM   1189 C CD2 . PHE A 1 159 ? 127.382 119.488 141.092 1.00 37.90  ? 159 PHE A CD2 1 
ATOM   1190 C CE1 . PHE A 1 159 ? 129.479 119.847 139.375 1.00 37.90  ? 159 PHE A CE1 1 
ATOM   1191 C CE2 . PHE A 1 159 ? 127.945 120.720 140.958 1.00 37.90  ? 159 PHE A CE2 1 
ATOM   1192 C CZ  . PHE A 1 159 ? 128.987 120.900 140.101 1.00 37.90  ? 159 PHE A CZ  1 
ATOM   1193 N N   . SER A 1 160 ? 126.957 115.950 143.540 1.00 39.74  ? 160 SER A N   1 
ATOM   1194 C CA  . SER A 1 160 ? 126.793 116.100 144.973 1.00 39.74  ? 160 SER A CA  1 
ATOM   1195 C C   . SER A 1 160 ? 126.096 114.860 145.506 1.00 39.74  ? 160 SER A C   1 
ATOM   1196 O O   . SER A 1 160 ? 125.119 114.392 144.917 1.00 39.74  ? 160 SER A O   1 
ATOM   1197 C CB  . SER A 1 160 ? 125.987 117.350 145.308 1.00 39.74  ? 160 SER A CB  1 
ATOM   1198 O OG  . SER A 1 160 ? 124.676 117.244 144.794 1.00 39.74  ? 160 SER A OG  1 
ATOM   1199 N N   . ILE A 1 161 ? 126.625 114.312 146.606 1.00 40.94  ? 161 ILE A N   1 
ATOM   1200 C CA  . ILE A 1 161 ? 126.136 113.077 147.207 1.00 40.94  ? 161 ILE A CA  1 
ATOM   1201 C C   . ILE A 1 161 ? 126.062 113.227 148.719 1.00 40.94  ? 161 ILE A C   1 
ATOM   1202 O O   . ILE A 1 161 ? 126.731 114.075 149.313 1.00 40.94  ? 161 ILE A O   1 
ATOM   1203 C CB  . ILE A 1 161 ? 127.023 111.873 146.848 1.00 40.94  ? 161 ILE A CB  1 
ATOM   1204 C CG1 . ILE A 1 161 ? 128.476 112.183 147.163 1.00 40.94  ? 161 ILE A CG1 1 
ATOM   1205 C CG2 . ILE A 1 161 ? 126.870 111.501 145.413 1.00 40.94  ? 161 ILE A CG2 1 
ATOM   1206 C CD1 . ILE A 1 161 ? 129.393 111.031 146.920 1.00 40.94  ? 161 ILE A CD1 1 
ATOM   1207 N N   . ASP A 1 162 ? 125.246 112.369 149.340 1.00 43.78  ? 162 ASP A N   1 
ATOM   1208 C CA  . ASP A 1 162 ? 125.060 112.345 150.787 1.00 43.78  ? 162 ASP A CA  1 
ATOM   1209 C C   . ASP A 1 162 ? 124.379 111.036 151.174 1.00 43.78  ? 162 ASP A C   1 
ATOM   1210 O O   . ASP A 1 162 ? 123.655 110.439 150.374 1.00 43.78  ? 162 ASP A O   1 
ATOM   1211 C CB  . ASP A 1 162 ? 124.229 113.544 151.259 1.00 43.78  ? 162 ASP A CB  1 
ATOM   1212 C CG  . ASP A 1 162 ? 124.397 113.824 152.727 1.00 43.78  ? 162 ASP A CG  1 
ATOM   1213 O OD1 . ASP A 1 162 ? 125.114 113.062 153.403 1.00 43.78  ? 162 ASP A OD1 1 
ATOM   1214 O OD2 . ASP A 1 162 ? 123.835 114.827 153.204 1.00 43.78  ? 162 ASP A OD2 1 
ATOM   1215 N N   . PHE A 1 163 ? 124.605 110.606 152.420 1.00 42.48  ? 163 PHE A N   1 
ATOM   1216 C CA  . PHE A 1 163 ? 124.041 109.370 152.963 1.00 42.48  ? 163 PHE A CA  1 
ATOM   1217 C C   . PHE A 1 163 ? 122.850 109.651 153.865 1.00 42.48  ? 163 PHE A C   1 
ATOM   1218 O O   . PHE A 1 163 ? 122.939 110.468 154.782 1.00 42.48  ? 163 PHE A O   1 
ATOM   1219 C CB  . PHE A 1 163 ? 125.079 108.576 153.756 1.00 42.48  ? 163 PHE A CB  1 
ATOM   1220 C CG  . PHE A 1 163 ? 125.998 107.736 152.915 1.00 42.48  ? 163 PHE A CG  1 
ATOM   1221 C CD1 . PHE A 1 163 ? 125.546 106.553 152.371 1.00 42.48  ? 163 PHE A CD1 1 
ATOM   1222 C CD2 . PHE A 1 163 ? 127.317 108.091 152.728 1.00 42.48  ? 163 PHE A CD2 1 
ATOM   1223 C CE1 . PHE A 1 163 ? 126.373 105.768 151.622 1.00 42.48  ? 163 PHE A CE1 1 
ATOM   1224 C CE2 . PHE A 1 163 ? 128.151 107.306 151.975 1.00 42.48  ? 163 PHE A CE2 1 
ATOM   1225 C CZ  . PHE A 1 163 ? 127.679 106.141 151.427 1.00 42.48  ? 163 PHE A CZ  1 
ATOM   1226 N N   . THR A 1 164 ? 121.754 108.949 153.616 1.00 43.15  ? 164 THR A N   1 
ATOM   1227 C CA  . THR A 1 164 ? 120.626 108.887 154.530 1.00 43.15  ? 164 THR A CA  1 
ATOM   1228 C C   . THR A 1 164 ? 120.958 107.895 155.640 1.00 43.15  ? 164 THR A C   1 
ATOM   1229 O O   . THR A 1 164 ? 121.687 106.927 155.413 1.00 43.15  ? 164 THR A O   1 
ATOM   1230 C CB  . THR A 1 164 ? 119.378 108.470 153.742 1.00 43.15  ? 164 THR A CB  1 
ATOM   1231 O OG1 . THR A 1 164 ? 119.106 109.453 152.743 1.00 43.15  ? 164 THR A OG1 1 
ATOM   1232 C CG2 . THR A 1 164 ? 118.143 108.300 154.589 1.00 43.15  ? 164 THR A CG2 1 
ATOM   1233 N N   . LYS A 1 165 ? 120.457 108.157 156.857 1.00 45.72  ? 165 LYS A N   1 
ATOM   1234 C CA  . LYS A 1 165 ? 120.697 107.266 157.989 1.00 45.72  ? 165 LYS A CA  1 
ATOM   1235 C C   . LYS A 1 165 ? 120.084 105.889 157.790 1.00 45.72  ? 165 LYS A C   1 
ATOM   1236 O O   . LYS A 1 165 ? 120.555 104.913 158.378 1.00 45.72  ? 165 LYS A O   1 
ATOM   1237 C CB  . LYS A 1 165 ? 120.139 107.874 159.267 1.00 45.72  ? 165 LYS A CB  1 
ATOM   1238 C CG  . LYS A 1 165 ? 120.839 109.120 159.730 1.00 45.72  ? 165 LYS A CG  1 
ATOM   1239 C CD  . LYS A 1 165 ? 120.327 109.527 161.093 1.00 45.72  ? 165 LYS A CD  1 
ATOM   1240 C CE  . LYS A 1 165 ? 118.916 110.068 161.009 1.00 45.72  ? 165 LYS A CE  1 
ATOM   1241 N NZ  . LYS A 1 165 ? 118.449 110.568 162.328 1.00 45.72  ? 165 LYS A NZ  1 
ATOM   1242 N N   . ALA A 1 166 ? 119.049 105.780 156.965 1.00 46.98  ? 166 ALA A N   1 
ATOM   1243 C CA  . ALA A 1 166 ? 118.340 104.525 156.760 1.00 46.98  ? 166 ALA A CA  1 
ATOM   1244 C C   . ALA A 1 166 ? 118.891 103.726 155.596 1.00 46.98  ? 166 ALA A C   1 
ATOM   1245 O O   . ALA A 1 166 ? 118.129 103.021 154.924 1.00 46.98  ? 166 ALA A O   1 
ATOM   1246 C CB  . ALA A 1 166 ? 116.848 104.791 156.560 1.00 46.98  ? 166 ALA A CB  1 
ATOM   1247 N N   . ASP A 1 167 ? 120.187 103.847 155.326 1.00 45.89  ? 167 ASP A N   1 
ATOM   1248 C CA  . ASP A 1 167 ? 120.963 103.160 154.295 1.00 45.89  ? 167 ASP A CA  1 
ATOM   1249 C C   . ASP A 1 167 ? 120.485 103.486 152.889 1.00 45.89  ? 167 ASP A C   1 
ATOM   1250 O O   . ASP A 1 167 ? 120.605 102.637 152.011 1.00 45.89  ? 167 ASP A O   1 
ATOM   1251 C CB  . ASP A 1 167 ? 120.986 101.631 154.467 1.00 45.89  ? 167 ASP A CB  1 
ATOM   1252 N N   . ARG A 1 168 ? 119.927 104.662 152.650 1.00 43.68  ? 168 ARG A N   1 
ATOM   1253 C CA  . ARG A 1 168 ? 119.795 105.155 151.295 1.00 43.68  ? 168 ARG A CA  1 
ATOM   1254 C C   . ARG A 1 168 ? 120.888 106.172 151.039 1.00 43.68  ? 168 ARG A C   1 
ATOM   1255 O O   . ARG A 1 168 ? 121.556 106.646 151.955 1.00 43.68  ? 168 ARG A O   1 
ATOM   1256 C CB  . ARG A 1 168 ? 118.435 105.790 151.060 1.00 43.68  ? 168 ARG A CB  1 
ATOM   1257 C CG  . ARG A 1 168 ? 117.302 104.853 151.277 1.00 43.68  ? 168 ARG A CG  1 
ATOM   1258 C CD  . ARG A 1 168 ? 116.005 105.538 150.994 1.00 43.68  ? 168 ARG A CD  1 
ATOM   1259 N NE  . ARG A 1 168 ? 115.800 105.708 149.571 1.00 43.68  ? 168 ARG A NE  1 
ATOM   1260 C CZ  . ARG A 1 168 ? 115.114 104.857 148.826 1.00 43.68  ? 168 ARG A CZ  1 
ATOM   1261 N NH1 . ARG A 1 168 ? 114.551 103.804 149.376 1.00 43.68  ? 168 ARG A NH1 1 
ATOM   1262 N NH2 . ARG A 1 168 ? 114.969 105.070 147.535 1.00 43.68  ? 168 ARG A NH2 1 
ATOM   1263 N N   . VAL A 1 169 ? 121.084 106.491 149.777 1.00 43.74  ? 169 VAL A N   1 
ATOM   1264 C CA  . VAL A 1 169 ? 122.076 107.470 149.382 1.00 43.74  ? 169 VAL A CA  1 
ATOM   1265 C C   . VAL A 1 169 ? 121.415 108.415 148.391 1.00 43.74  ? 169 VAL A C   1 
ATOM   1266 O O   . VAL A 1 169 ? 120.585 107.995 147.581 1.00 43.74  ? 169 VAL A O   1 
ATOM   1267 C CB  . VAL A 1 169 ? 123.341 106.787 148.815 1.00 43.74  ? 169 VAL A CB  1 
ATOM   1268 C CG1 . VAL A 1 169 ? 123.063 105.995 147.557 1.00 43.74  ? 169 VAL A CG1 1 
ATOM   1269 C CG2 . VAL A 1 169 ? 124.423 107.789 148.582 1.00 43.74  ? 169 VAL A CG2 1 
ATOM   1270 N N   . LEU A 1 170 ? 121.714 109.704 148.511 1.00 43.19  ? 170 LEU A N   1 
ATOM   1271 C CA  . LEU A 1 170 ? 121.108 110.718 147.666 1.00 43.19  ? 170 LEU A CA  1 
ATOM   1272 C C   . LEU A 1 170 ? 122.111 111.155 146.615 1.00 43.19  ? 170 LEU A C   1 
ATOM   1273 O O   . LEU A 1 170 ? 123.217 111.583 146.949 1.00 43.19  ? 170 LEU A O   1 
ATOM   1274 C CB  . LEU A 1 170 ? 120.640 111.914 148.491 1.00 43.19  ? 170 LEU A CB  1 
ATOM   1275 C CG  . LEU A 1 170 ? 119.920 113.008 147.720 1.00 43.19  ? 170 LEU A CG  1 
ATOM   1276 C CD1 . LEU A 1 170 ? 118.674 112.459 147.095 1.00 43.19  ? 170 LEU A CD1 1 
ATOM   1277 C CD2 . LEU A 1 170 ? 119.595 114.135 148.645 1.00 43.19  ? 170 LEU A CD2 1 
ATOM   1278 N N   . LEU A 1 171 ? 121.720 111.045 145.352 1.00 43.06  ? 171 LEU A N   1 
ATOM   1279 C CA  . LEU A 1 171 ? 122.535 111.473 144.233 1.00 43.06  ? 171 LEU A CA  1 
ATOM   1280 C C   . LEU A 1 171 ? 121.980 112.781 143.699 1.00 43.06  ? 171 LEU A C   1 
ATOM   1281 O O   . LEU A 1 171 ? 120.769 112.911 143.505 1.00 43.06  ? 171 LEU A O   1 
ATOM   1282 C CB  . LEU A 1 171 ? 122.523 110.452 143.106 1.00 43.06  ? 171 LEU A CB  1 
ATOM   1283 C CG  . LEU A 1 171 ? 123.618 110.708 142.088 1.00 43.06  ? 171 LEU A CG  1 
ATOM   1284 C CD1 . LEU A 1 171 ? 124.889 110.115 142.623 1.00 43.06  ? 171 LEU A CD1 1 
ATOM   1285 C CD2 . LEU A 1 171 ? 123.281 110.213 140.714 1.00 43.06  ? 171 LEU A CD2 1 
ATOM   1286 N N   . GLY A 1 172 ? 122.865 113.740 143.441 1.00 40.71  ? 172 GLY A N   1 
ATOM   1287 C CA  . GLY A 1 172 ? 122.446 114.982 142.829 1.00 40.71  ? 172 GLY A CA  1 
ATOM   1288 C C   . GLY A 1 172 ? 123.055 115.182 141.462 1.00 40.71  ? 172 GLY A C   1 
ATOM   1289 O O   . GLY A 1 172 ? 124.263 115.386 141.348 1.00 40.71  ? 172 GLY A O   1 
ATOM   1290 N N   . GLY A 1 173 ? 122.237 115.129 140.419 1.00 39.26  ? 173 GLY A N   1 
ATOM   1291 C CA  . GLY A 1 173 ? 122.713 115.333 139.072 1.00 39.26  ? 173 GLY A CA  1 
ATOM   1292 C C   . GLY A 1 173 ? 122.099 116.565 138.451 1.00 39.26  ? 173 GLY A C   1 
ATOM   1293 O O   . GLY A 1 173 ? 120.899 116.612 138.189 1.00 39.26  ? 173 GLY A O   1 
ATOM   1294 N N   . PRO A 1 174 ? 122.906 117.575 138.187 1.00 36.95  ? 174 PRO A N   1 
ATOM   1295 C CA  . PRO A 1 174 ? 122.367 118.907 137.921 1.00 36.95  ? 174 PRO A CA  1 
ATOM   1296 C C   . PRO A 1 174 ? 122.123 119.223 136.460 1.00 36.95  ? 174 PRO A C   1 
ATOM   1297 O O   . PRO A 1 174 ? 121.910 120.387 136.114 1.00 36.95  ? 174 PRO A O   1 
ATOM   1298 C CB  . PRO A 1 174 ? 123.457 119.811 138.479 1.00 36.95  ? 174 PRO A CB  1 
ATOM   1299 C CG  . PRO A 1 174 ? 124.654 119.057 138.219 1.00 36.95  ? 174 PRO A CG  1 
ATOM   1300 C CD  . PRO A 1 174 ? 124.352 117.624 138.383 1.00 36.95  ? 174 PRO A CD  1 
ATOM   1301 N N   . GLY A 1 175 ? 122.163 118.223 135.590 1.00 38.77  ? 175 GLY A N   1 
ATOM   1302 C CA  . GLY A 1 175 ? 122.070 118.497 134.173 1.00 38.77  ? 175 GLY A CA  1 
ATOM   1303 C C   . GLY A 1 175 ? 120.982 117.729 133.477 1.00 38.77  ? 175 GLY A C   1 
ATOM   1304 O O   . GLY A 1 175 ? 120.869 117.786 132.256 1.00 38.77  ? 175 GLY A O   1 
ATOM   1305 N N   . SER A 1 176 ? 120.178 117.009 134.239 1.00 40.46  ? 176 SER A N   1 
ATOM   1306 C CA  . SER A 1 176 ? 119.160 116.162 133.648 1.00 40.46  ? 176 SER A CA  1 
ATOM   1307 C C   . SER A 1 176 ? 117.994 116.990 133.142 1.00 40.46  ? 176 SER A C   1 
ATOM   1308 O O   . SER A 1 176 ? 117.625 118.001 133.736 1.00 40.46  ? 176 SER A O   1 
ATOM   1309 C CB  . SER A 1 176 ? 118.656 115.144 134.662 1.00 40.46  ? 176 SER A CB  1 
ATOM   1310 O OG  . SER A 1 176 ? 119.695 114.284 135.075 1.00 40.46  ? 176 SER A OG  1 
ATOM   1311 N N   . PHE A 1 177 ? 117.435 116.543 132.022 1.00 42.58  ? 177 PHE A N   1 
ATOM   1312 C CA  . PHE A 1 177 ? 116.225 117.073 131.400 1.00 42.58  ? 177 PHE A CA  1 
ATOM   1313 C C   . PHE A 1 177 ? 116.369 118.549 131.038 1.00 42.58  ? 177 PHE A C   1 
ATOM   1314 O O   . PHE A 1 177 ? 115.619 119.396 131.512 1.00 42.58  ? 177 PHE A O   1 
ATOM   1315 C CB  . PHE A 1 177 ? 115.010 116.850 132.302 1.00 42.58  ? 177 PHE A CB  1 
ATOM   1316 C CG  . PHE A 1 177 ? 114.822 115.427 132.712 1.00 42.58  ? 177 PHE A CG  1 
ATOM   1317 C CD1 . PHE A 1 177 ? 114.361 114.485 131.809 1.00 42.58  ? 177 PHE A CD1 1 
ATOM   1318 C CD2 . PHE A 1 177 ? 115.088 115.033 134.010 1.00 42.58  ? 177 PHE A CD2 1 
ATOM   1319 C CE1 . PHE A 1 177 ? 114.196 113.169 132.187 1.00 42.58  ? 177 PHE A CE1 1 
ATOM   1320 C CE2 . PHE A 1 177 ? 114.916 113.726 134.394 1.00 42.58  ? 177 PHE A CE2 1 
ATOM   1321 C CZ  . PHE A 1 177 ? 114.466 112.793 133.481 1.00 42.58  ? 177 PHE A CZ  1 
ATOM   1322 N N   . TYR A 1 178 ? 117.329 118.826 130.151 1.00 42.18  ? 178 TYR A N   1 
ATOM   1323 C CA  . TYR A 1 178 ? 117.728 120.181 129.752 1.00 42.18  ? 178 TYR A CA  1 
ATOM   1324 C C   . TYR A 1 178 ? 118.102 121.021 130.961 1.00 42.18  ? 178 TYR A C   1 
ATOM   1325 O O   . TYR A 1 178 ? 117.610 122.132 131.139 1.00 42.18  ? 178 TYR A O   1 
ATOM   1326 C CB  . TYR A 1 178 ? 116.658 120.907 128.925 1.00 42.18  ? 178 TYR A CB  1 
ATOM   1327 C CG  . TYR A 1 178 ? 116.439 120.407 127.525 1.00 42.18  ? 178 TYR A CG  1 
ATOM   1328 C CD1 . TYR A 1 178 ? 117.369 120.653 126.532 1.00 42.18  ? 178 TYR A CD1 1 
ATOM   1329 C CD2 . TYR A 1 178 ? 115.276 119.752 127.186 1.00 42.18  ? 178 TYR A CD2 1 
ATOM   1330 C CE1 . TYR A 1 178 ? 117.171 120.216 125.256 1.00 42.18  ? 178 TYR A CE1 1 
ATOM   1331 C CE2 . TYR A 1 178 ? 115.061 119.316 125.908 1.00 42.18  ? 178 TYR A CE2 1 
ATOM   1332 C CZ  . TYR A 1 178 ? 116.013 119.550 124.946 1.00 42.18  ? 178 TYR A CZ  1 
ATOM   1333 O OH  . TYR A 1 178 ? 115.800 119.110 123.662 1.00 42.18  ? 178 TYR A OH  1 
ATOM   1334 N N   . TRP A 1 179 ? 118.969 120.458 131.797 1.00 40.04  ? 179 TRP A N   1 
ATOM   1335 C CA  . TRP A 1 179 ? 119.523 121.098 132.994 1.00 40.04  ? 179 TRP A CA  1 
ATOM   1336 C C   . TRP A 1 179 ? 118.446 121.522 133.981 1.00 40.04  ? 179 TRP A C   1 
ATOM   1337 O O   . TRP A 1 179 ? 118.627 122.473 134.733 1.00 40.04  ? 179 TRP A O   1 
ATOM   1338 C CB  . TRP A 1 179 ? 120.436 122.273 132.639 1.00 40.04  ? 179 TRP A CB  1 
ATOM   1339 C CG  . TRP A 1 179 ? 121.714 121.834 132.029 1.00 40.04  ? 179 TRP A CG  1 
ATOM   1340 C CD1 . TRP A 1 179 ? 122.881 121.618 132.666 1.00 40.04  ? 179 TRP A CD1 1 
ATOM   1341 C CD2 . TRP A 1 179 ? 121.939 121.503 130.657 1.00 40.04  ? 179 TRP A CD2 1 
ATOM   1342 N NE1 . TRP A 1 179 ? 123.835 121.200 131.782 1.00 40.04  ? 179 TRP A NE1 1 
ATOM   1343 C CE2 . TRP A 1 179 ? 123.275 121.121 130.538 1.00 40.04  ? 179 TRP A CE2 1 
ATOM   1344 C CE3 . TRP A 1 179 ? 121.139 121.510 129.514 1.00 40.04  ? 179 TRP A CE3 1 
ATOM   1345 C CZ2 . TRP A 1 179 ? 123.828 120.744 129.331 1.00 40.04  ? 179 TRP A CZ2 1 
ATOM   1346 C CZ3 . TRP A 1 179 ? 121.686 121.139 128.326 1.00 40.04  ? 179 TRP A CZ3 1 
ATOM   1347 C CH2 . TRP A 1 179 ? 123.017 120.761 128.238 1.00 40.04  ? 179 TRP A CH2 1 
ATOM   1348 N N   . GLN A 1 180 ? 117.320 120.807 134.000 1.00 40.70  ? 180 GLN A N   1 
ATOM   1349 C CA  . GLN A 1 180 ? 116.428 120.885 135.143 1.00 40.70  ? 180 GLN A CA  1 
ATOM   1350 C C   . GLN A 1 180 ? 117.064 120.307 136.388 1.00 40.70  ? 180 GLN A C   1 
ATOM   1351 O O   . GLN A 1 180 ? 116.701 120.708 137.495 1.00 40.70  ? 180 GLN A O   1 
ATOM   1352 C CB  . GLN A 1 180 ? 115.123 120.152 134.874 1.00 40.70  ? 180 GLN A CB  1 
ATOM   1353 C CG  . GLN A 1 180 ? 114.211 120.887 133.983 1.00 40.70  ? 180 GLN A CG  1 
ATOM   1354 C CD  . GLN A 1 180 ? 112.945 120.146 133.720 1.00 40.70  ? 180 GLN A CD  1 
ATOM   1355 O OE1 . GLN A 1 180 ? 112.766 119.026 134.178 1.00 40.70  ? 180 GLN A OE1 1 
ATOM   1356 N NE2 . GLN A 1 180 ? 112.047 120.762 132.979 1.00 40.70  ? 180 GLN A NE2 1 
ATOM   1357 N N   . GLY A 1 181 ? 117.989 119.371 136.233 1.00 39.29  ? 181 GLY A N   1 
ATOM   1358 C CA  . GLY A 1 181 ? 118.586 118.714 137.366 1.00 39.29  ? 181 GLY A CA  1 
ATOM   1359 C C   . GLY A 1 181 ? 117.717 117.586 137.859 1.00 39.29  ? 181 GLY A C   1 
ATOM   1360 O O   . GLY A 1 181 ? 116.556 117.485 137.462 1.00 39.29  ? 181 GLY A O   1 
ATOM   1361 N N   . GLN A 1 182 ? 118.252 116.733 138.721 1.00 40.76  ? 182 GLN A N   1 
ATOM   1362 C CA  . GLN A 1 182 ? 117.475 115.613 139.219 1.00 40.76  ? 182 GLN A CA  1 
ATOM   1363 C C   . GLN A 1 182 ? 118.093 115.146 140.521 1.00 40.76  ? 182 GLN A C   1 
ATOM   1364 O O   . GLN A 1 182 ? 119.312 115.171 140.680 1.00 40.76  ? 182 GLN A O   1 
ATOM   1365 C CB  . GLN A 1 182 ? 117.444 114.469 138.203 1.00 40.76  ? 182 GLN A CB  1 
ATOM   1366 C CG  . GLN A 1 182 ? 116.475 113.370 138.507 1.00 40.76  ? 182 GLN A CG  1 
ATOM   1367 C CD  . GLN A 1 182 ? 116.498 112.297 137.464 1.00 40.76  ? 182 GLN A CD  1 
ATOM   1368 O OE1 . GLN A 1 182 ? 117.311 112.324 136.552 1.00 40.76  ? 182 GLN A OE1 1 
ATOM   1369 N NE2 . GLN A 1 182 ? 115.592 111.344 137.582 1.00 40.76  ? 182 GLN A NE2 1 
ATOM   1370 N N   . LEU A 1 183 ? 117.245 114.752 141.459 1.00 42.01  ? 183 LEU A N   1 
ATOM   1371 C CA  . LEU A 1 183 ? 117.674 113.953 142.593 1.00 42.01  ? 183 LEU A CA  1 
ATOM   1372 C C   . LEU A 1 183 ? 117.376 112.496 142.298 1.00 42.01  ? 183 LEU A C   1 
ATOM   1373 O O   . LEU A 1 183 ? 116.362 112.173 141.679 1.00 42.01  ? 183 LEU A O   1 
ATOM   1374 C CB  . LEU A 1 183 ? 116.984 114.354 143.891 1.00 42.01  ? 183 LEU A CB  1 
ATOM   1375 C CG  . LEU A 1 183 ? 117.329 115.695 144.501 1.00 42.01  ? 183 LEU A CG  1 
ATOM   1376 C CD1 . LEU A 1 183 ? 116.524 115.892 145.751 1.00 42.01  ? 183 LEU A CD1 1 
ATOM   1377 C CD2 . LEU A 1 183 ? 118.792 115.766 144.780 1.00 42.01  ? 183 LEU A CD2 1 
ATOM   1378 N N   . ILE A 1 184 ? 118.281 111.627 142.729 1.00 42.69  ? 184 ILE A N   1 
ATOM   1379 C CA  . ILE A 1 184 ? 118.140 110.184 142.604 1.00 42.69  ? 184 ILE A CA  1 
ATOM   1380 C C   . ILE A 1 184 ? 118.520 109.599 143.951 1.00 42.69  ? 184 ILE A C   1 
ATOM   1381 O O   . ILE A 1 184 ? 119.613 109.862 144.454 1.00 42.69  ? 184 ILE A O   1 
ATOM   1382 C CB  . ILE A 1 184 ? 119.016 109.604 141.487 1.00 42.69  ? 184 ILE A CB  1 
ATOM   1383 C CG1 . ILE A 1 184 ? 118.434 109.951 140.122 1.00 42.69  ? 184 ILE A CG1 1 
ATOM   1384 C CG2 . ILE A 1 184 ? 119.175 108.125 141.633 1.00 42.69  ? 184 ILE A CG2 1 
ATOM   1385 C CD1 . ILE A 1 184 ? 119.346 109.623 138.979 1.00 42.69  ? 184 ILE A CD1 1 
ATOM   1386 N N   . SER A 1 185 ? 117.619 108.843 144.552 1.00 44.71  ? 185 SER A N   1 
ATOM   1387 C CA  . SER A 1 185 ? 117.895 108.209 145.826 1.00 44.71  ? 185 SER A CA  1 
ATOM   1388 C C   . SER A 1 185 ? 117.579 106.731 145.750 1.00 44.71  ? 185 SER A C   1 
ATOM   1389 O O   . SER A 1 185 ? 116.548 106.335 145.207 1.00 44.71  ? 185 SER A O   1 
ATOM   1390 C CB  . SER A 1 185 ? 117.105 108.827 146.957 1.00 44.71  ? 185 SER A CB  1 
ATOM   1391 O OG  . SER A 1 185 ? 117.450 108.188 148.168 1.00 44.71  ? 185 SER A OG  1 
ATOM   1392 N N   . ASP A 1 186 ? 118.462 105.924 146.321 1.00 45.61  ? 186 ASP A N   1 
ATOM   1393 C CA  . ASP A 1 186 ? 118.319 104.485 146.219 1.00 45.61  ? 186 ASP A CA  1 
ATOM   1394 C C   . ASP A 1 186 ? 119.054 103.833 147.378 1.00 45.61  ? 186 ASP A C   1 
ATOM   1395 O O   . ASP A 1 186 ? 120.024 104.379 147.902 1.00 45.61  ? 186 ASP A O   1 
ATOM   1396 C CB  . ASP A 1 186 ? 118.865 103.980 144.889 1.00 45.61  ? 186 ASP A CB  1 
ATOM   1397 C CG  . ASP A 1 186 ? 118.401 102.601 144.569 1.00 45.61  ? 186 ASP A CG  1 
ATOM   1398 O OD1 . ASP A 1 186 ? 117.509 102.086 145.265 1.00 45.61  ? 186 ASP A OD1 1 
ATOM   1399 O OD2 . ASP A 1 186 ? 118.975 102.007 143.654 1.00 45.61  ? 186 ASP A OD2 1 
ATOM   1400 N N   . GLN A 1 187 ? 118.582 102.652 147.753 1.00 44.04  ? 187 GLN A N   1 
ATOM   1401 C CA  . GLN A 1 187 ? 119.131 101.910 148.871 1.00 44.04  ? 187 GLN A CA  1 
ATOM   1402 C C   . GLN A 1 187 ? 120.503 101.356 148.529 1.00 44.04  ? 187 GLN A C   1 
ATOM   1403 O O   . GLN A 1 187 ? 120.786 101.017 147.383 1.00 44.04  ? 187 GLN A O   1 
ATOM   1404 C CB  . GLN A 1 187 ? 118.188 100.777 149.221 1.00 44.04  ? 187 GLN A CB  1 
ATOM   1405 C CG  . GLN A 1 187 ? 116.840 101.281 149.628 1.00 44.04  ? 187 GLN A CG  1 
ATOM   1406 C CD  . GLN A 1 187 ? 115.837 100.182 149.790 1.00 44.04  ? 187 GLN A CD  1 
ATOM   1407 O OE1 . GLN A 1 187 ? 116.122 99.021  149.508 1.00 44.04  ? 187 GLN A OE1 1 
ATOM   1408 N NE2 . GLN A 1 187 ? 114.645 100.535 150.245 1.00 44.04  ? 187 GLN A NE2 1 
ATOM   1409 N N   . VAL A 1 188 ? 121.357 101.259 149.546 1.00 42.20  ? 188 VAL A N   1 
ATOM   1410 C CA  . VAL A 1 188 ? 122.706 100.737 149.354 1.00 42.20  ? 188 VAL A CA  1 
ATOM   1411 C C   . VAL A 1 188 ? 122.671 99.228  149.145 1.00 42.20  ? 188 VAL A C   1 
ATOM   1412 O O   . VAL A 1 188 ? 123.528 98.662  148.458 1.00 42.20  ? 188 VAL A O   1 
ATOM   1413 C CB  . VAL A 1 188 ? 123.567 101.174 150.552 1.00 42.20  ? 188 VAL A CB  1 
ATOM   1414 C CG1 . VAL A 1 188 ? 124.960 100.628 150.490 1.00 42.20  ? 188 VAL A CG1 1 
ATOM   1415 C CG2 . VAL A 1 188 ? 123.633 102.677 150.595 1.00 42.20  ? 188 VAL A CG2 1 
ATOM   1416 N N   . ALA A 1 189 ? 121.650 98.558  149.674 1.00 43.00  ? 189 ALA A N   1 
ATOM   1417 C CA  . ALA A 1 189 ? 121.474 97.137  149.402 1.00 43.00  ? 189 ALA A CA  1 
ATOM   1418 C C   . ALA A 1 189 ? 121.054 96.886  147.959 1.00 43.00  ? 189 ALA A C   1 
ATOM   1419 O O   . ALA A 1 189 ? 121.366 95.836  147.398 1.00 43.00  ? 189 ALA A O   1 
ATOM   1420 C CB  . ALA A 1 189 ? 120.449 96.545  150.363 1.00 43.00  ? 189 ALA A CB  1 
ATOM   1421 N N   . GLU A 1 190 ? 120.337 97.827  147.344 1.00 44.47  ? 190 GLU A N   1 
ATOM   1422 C CA  . GLU A 1 190 ? 119.989 97.689  145.935 1.00 44.47  ? 190 GLU A CA  1 
ATOM   1423 C C   . GLU A 1 190 ? 121.190 97.905  145.032 1.00 44.47  ? 190 GLU A C   1 
ATOM   1424 O O   . GLU A 1 190 ? 121.232 97.375  143.921 1.00 44.47  ? 190 GLU A O   1 
ATOM   1425 C CB  . GLU A 1 190 ? 118.902 98.686  145.564 1.00 44.47  ? 190 GLU A CB  1 
ATOM   1426 C CG  . GLU A 1 190 ? 117.563 98.390  146.139 1.00 44.47  ? 190 GLU A CG  1 
ATOM   1427 C CD  . GLU A 1 190 ? 116.910 97.237  145.446 1.00 44.47  ? 190 GLU A CD  1 
ATOM   1428 O OE1 . GLU A 1 190 ? 117.147 97.086  144.236 1.00 44.47  ? 190 GLU A OE1 1 
ATOM   1429 O OE2 . GLU A 1 190 ? 116.159 96.487  146.100 1.00 44.47  ? 190 GLU A OE2 1 
ATOM   1430 N N   . ILE A 1 191 ? 122.157 98.702  145.473 1.00 43.50  ? 191 ILE A N   1 
ATOM   1431 C CA  . ILE A 1 191 ? 123.284 99.044  144.618 1.00 43.50  ? 191 ILE A CA  1 
ATOM   1432 C C   . ILE A 1 191 ? 124.280 97.901  144.580 1.00 43.50  ? 191 ILE A C   1 
ATOM   1433 O O   . ILE A 1 191 ? 124.762 97.509  143.512 1.00 43.50  ? 191 ILE A O   1 
ATOM   1434 C CB  . ILE A 1 191 ? 123.943 100.344 145.103 1.00 43.50  ? 191 ILE A CB  1 
ATOM   1435 C CG1 . ILE A 1 191 ? 122.952 101.494 145.024 1.00 43.50  ? 191 ILE A CG1 1 
ATOM   1436 C CG2 . ILE A 1 191 ? 125.157 100.684 144.267 1.00 43.50  ? 191 ILE A CG2 1 
ATOM   1437 C CD1 . ILE A 1 191 ? 123.409 102.724 145.762 1.00 43.50  ? 191 ILE A CD1 1 
ATOM   1438 N N   . VAL A 1 192 ? 124.602 97.351  145.748 1.00 42.66  ? 192 VAL A N   1 
ATOM   1439 C CA  . VAL A 1 192 ? 125.627 96.320  145.841 1.00 42.66  ? 192 VAL A CA  1 
ATOM   1440 C C   . VAL A 1 192 ? 125.117 95.010  145.263 1.00 42.66  ? 192 VAL A C   1 
ATOM   1441 O O   . VAL A 1 192 ? 125.833 94.314  144.535 1.00 42.66  ? 192 VAL A O   1 
ATOM   1442 C CB  . VAL A 1 192 ? 126.075 96.167  147.302 1.00 42.66  ? 192 VAL A CB  1 
ATOM   1443 C CG1 . VAL A 1 192 ? 127.062 95.040  147.451 1.00 42.66  ? 192 VAL A CG1 1 
ATOM   1444 C CG2 . VAL A 1 192 ? 126.681 97.459  147.789 1.00 42.66  ? 192 VAL A CG2 1 
ATOM   1445 N N   . SER A 1 193 ? 123.863 94.670  145.554 1.00 43.96  ? 193 SER A N   1 
ATOM   1446 C CA  . SER A 1 193 ? 123.300 93.417  145.070 1.00 43.96  ? 193 SER A CA  1 
ATOM   1447 C C   . SER A 1 193 ? 123.083 93.455  143.569 1.00 43.96  ? 193 SER A C   1 
ATOM   1448 O O   . SER A 1 193 ? 123.647 92.648  142.826 1.00 43.96  ? 193 SER A O   1 
ATOM   1449 C CB  . SER A 1 193 ? 121.989 93.115  145.786 1.00 43.96  ? 193 SER A CB  1 
ATOM   1450 O OG  . SER A 1 193 ? 121.392 91.943  145.269 1.00 43.96  ? 193 SER A OG  1 
ATOM   1451 N N   . LYS A 1 194 ? 122.274 94.395  143.097 1.00 44.32  ? 194 LYS A N   1 
ATOM   1452 C CA  . LYS A 1 194 ? 121.963 94.466  141.674 1.00 44.32  ? 194 LYS A CA  1 
ATOM   1453 C C   . LYS A 1 194 ? 123.106 95.191  140.982 1.00 44.32  ? 194 LYS A C   1 
ATOM   1454 O O   . LYS A 1 194 ? 123.038 96.377  140.658 1.00 44.32  ? 194 LYS A O   1 
ATOM   1455 C CB  . LYS A 1 194 ? 120.623 95.145  141.449 1.00 44.32  ? 194 LYS A CB  1 
ATOM   1456 C CG  . LYS A 1 194 ? 119.498 94.358  142.066 1.00 44.32  ? 194 LYS A CG  1 
ATOM   1457 C CD  . LYS A 1 194 ? 118.162 95.020  141.904 1.00 44.32  ? 194 LYS A CD  1 
ATOM   1458 C CE  . LYS A 1 194 ? 117.638 94.830  140.507 1.00 44.32  ? 194 LYS A CE  1 
ATOM   1459 N NZ  . LYS A 1 194 ? 116.244 95.336  140.369 1.00 44.32  ? 194 LYS A NZ  1 
ATOM   1460 N N   . TYR A 1 195 ? 124.191 94.459  140.774 1.00 44.13  ? 195 TYR A N   1 
ATOM   1461 C CA  . TYR A 1 195 ? 125.329 94.958  140.022 1.00 44.13  ? 195 TYR A CA  1 
ATOM   1462 C C   . TYR A 1 195 ? 125.919 93.823  139.213 1.00 44.13  ? 195 TYR A C   1 
ATOM   1463 O O   . TYR A 1 195 ? 126.666 92.998  139.745 1.00 44.13  ? 195 TYR A O   1 
ATOM   1464 C CB  . TYR A 1 195 ? 126.379 95.559  140.936 1.00 44.13  ? 195 TYR A CB  1 
ATOM   1465 C CG  . TYR A 1 195 ? 127.658 95.892  140.230 1.00 44.13  ? 195 TYR A CG  1 
ATOM   1466 C CD1 . TYR A 1 195 ? 127.701 96.867  139.266 1.00 44.13  ? 195 TYR A CD1 1 
ATOM   1467 C CD2 . TYR A 1 195 ? 128.835 95.257  140.572 1.00 44.13  ? 195 TYR A CD2 1 
ATOM   1468 C CE1 . TYR A 1 195 ? 128.872 97.174  138.636 1.00 44.13  ? 195 TYR A CE1 1 
ATOM   1469 C CE2 . TYR A 1 195 ? 130.006 95.567  139.957 1.00 44.13  ? 195 TYR A CE2 1 
ATOM   1470 C CZ  . TYR A 1 195 ? 130.021 96.524  138.991 1.00 44.13  ? 195 TYR A CZ  1 
ATOM   1471 O OH  . TYR A 1 195 ? 131.198 96.837  138.369 1.00 44.13  ? 195 TYR A OH  1 
ATOM   1472 N N   . ASP A 1 196 ? 125.563 93.779  137.938 1.00 50.36  ? 196 ASP A N   1 
ATOM   1473 C CA  . ASP A 1 196 ? 126.226 92.939  136.951 1.00 50.36  ? 196 ASP A CA  1 
ATOM   1474 C C   . ASP A 1 196 ? 127.256 93.835  136.298 1.00 50.36  ? 196 ASP A C   1 
ATOM   1475 O O   . ASP A 1 196 ? 126.885 94.886  135.745 1.00 50.36  ? 196 ASP A O   1 
ATOM   1476 C CB  . ASP A 1 196 ? 125.222 92.414  135.928 1.00 50.36  ? 196 ASP A CB  1 
ATOM   1477 C CG  . ASP A 1 196 ? 125.781 91.306  135.061 1.00 50.36  ? 196 ASP A CG  1 
ATOM   1478 O OD1 . ASP A 1 196 ? 126.963 90.944  135.214 1.00 50.36  ? 196 ASP A OD1 1 
ATOM   1479 O OD2 . ASP A 1 196 ? 125.024 90.780  134.220 1.00 50.36  ? 196 ASP A OD2 1 
ATOM   1480 N N   . PRO A 1 197 ? 128.550 93.509  136.349 1.00 49.65  ? 197 PRO A N   1 
ATOM   1481 C CA  . PRO A 1 197 ? 129.551 94.383  135.721 1.00 49.65  ? 197 PRO A CA  1 
ATOM   1482 C C   . PRO A 1 197 ? 129.568 94.320  134.209 1.00 49.65  ? 197 PRO A C   1 
ATOM   1483 O O   . PRO A 1 197 ? 130.353 95.050  133.593 1.00 49.65  ? 197 PRO A O   1 
ATOM   1484 C CB  . PRO A 1 197 ? 130.870 93.878  136.301 1.00 49.65  ? 197 PRO A CB  1 
ATOM   1485 C CG  . PRO A 1 197 ? 130.597 92.471  136.649 1.00 49.65  ? 197 PRO A CG  1 
ATOM   1486 C CD  . PRO A 1 197 ? 129.174 92.414  137.100 1.00 49.65  ? 197 PRO A CD  1 
ATOM   1487 N N   . ASN A 1 198 ? 128.747 93.475  133.591 1.00 50.69  ? 198 ASN A N   1 
ATOM   1488 C CA  . ASN A 1 198 ? 128.593 93.438  132.148 1.00 50.69  ? 198 ASN A CA  1 
ATOM   1489 C C   . ASN A 1 198 ? 127.247 93.984  131.692 1.00 50.69  ? 198 ASN A C   1 
ATOM   1490 O O   . ASN A 1 198 ? 126.880 93.802  130.529 1.00 50.69  ? 198 ASN A O   1 
ATOM   1491 C CB  . ASN A 1 198 ? 128.783 92.011  131.638 1.00 50.69  ? 198 ASN A CB  1 
ATOM   1492 N N   . VAL A 1 199 ? 126.500 94.633  132.577 1.00 50.63  ? 199 VAL A N   1 
ATOM   1493 C CA  . VAL A 1 199 ? 125.255 95.307  132.232 1.00 50.63  ? 199 VAL A CA  1 
ATOM   1494 C C   . VAL A 1 199 ? 125.453 96.798  132.447 1.00 50.63  ? 199 VAL A C   1 
ATOM   1495 O O   . VAL A 1 199 ? 125.958 97.223  133.491 1.00 50.63  ? 199 VAL A O   1 
ATOM   1496 C CB  . VAL A 1 199 ? 124.072 94.767  133.057 1.00 50.63  ? 199 VAL A CB  1 
ATOM   1497 C CG1 . VAL A 1 199 ? 122.847 95.635  132.901 1.00 50.63  ? 199 VAL A CG1 1 
ATOM   1498 C CG2 . VAL A 1 199 ? 123.748 93.375  132.598 1.00 50.63  ? 199 VAL A CG2 1 
ATOM   1499 N N   . TYR A 1 200 ? 125.064 97.592  131.451 1.00 51.28  ? 200 TYR A N   1 
ATOM   1500 C CA  . TYR A 1 200 ? 125.477 98.985  131.342 1.00 51.28  ? 200 TYR A CA  1 
ATOM   1501 C C   . TYR A 1 200 ? 124.463 99.959  131.923 1.00 51.28  ? 200 TYR A C   1 
ATOM   1502 O O   . TYR A 1 200 ? 124.847 101.019 132.420 1.00 51.28  ? 200 TYR A O   1 
ATOM   1503 C CB  . TYR A 1 200 ? 125.743 99.313  129.871 1.00 51.28  ? 200 TYR A CB  1 
ATOM   1504 C CG  . TYR A 1 200 ? 126.895 98.520  129.275 1.00 51.28  ? 200 TYR A CG  1 
ATOM   1505 C CD1 . TYR A 1 200 ? 127.911 98.007  130.079 1.00 51.28  ? 200 TYR A CD1 1 
ATOM   1506 C CD2 . TYR A 1 200 ? 126.926 98.230  127.921 1.00 51.28  ? 200 TYR A CD2 1 
ATOM   1507 C CE1 . TYR A 1 200 ? 128.936 97.269  129.546 1.00 51.28  ? 200 TYR A CE1 1 
ATOM   1508 C CE2 . TYR A 1 200 ? 127.954 97.491  127.378 1.00 51.28  ? 200 TYR A CE2 1 
ATOM   1509 C CZ  . TYR A 1 200 ? 128.951 97.008  128.197 1.00 51.28  ? 200 TYR A CZ  1 
ATOM   1510 O OH  . TYR A 1 200 ? 129.981 96.274  127.661 1.00 51.28  ? 200 TYR A OH  1 
ATOM   1511 N N   . SER A 1 201 ? 123.180 99.632  131.868 1.00 50.19  ? 201 SER A N   1 
ATOM   1512 C CA  . SER A 1 201 ? 122.127 100.425 132.489 1.00 50.19  ? 201 SER A CA  1 
ATOM   1513 C C   . SER A 1 201 ? 121.343 99.502  133.410 1.00 50.19  ? 201 SER A C   1 
ATOM   1514 O O   . SER A 1 201 ? 120.582 98.652  132.939 1.00 50.19  ? 201 SER A O   1 
ATOM   1515 C CB  . SER A 1 201 ? 121.219 101.051 131.438 1.00 50.19  ? 201 SER A CB  1 
ATOM   1516 O OG  . SER A 1 201 ? 120.485 100.052 130.759 1.00 50.19  ? 201 SER A OG  1 
ATOM   1517 N N   . ILE A 1 202 ? 121.524 99.672  134.715 1.00 47.32  ? 202 ILE A N   1 
ATOM   1518 C CA  . ILE A 1 202 ? 120.951 98.786  135.718 1.00 47.32  ? 202 ILE A CA  1 
ATOM   1519 C C   . ILE A 1 202 ? 119.627 99.366  136.181 1.00 47.32  ? 202 ILE A C   1 
ATOM   1520 O O   . ILE A 1 202 ? 119.534 100.560 136.482 1.00 47.32  ? 202 ILE A O   1 
ATOM   1521 C CB  . ILE A 1 202 ? 121.918 98.605  136.901 1.00 47.32  ? 202 ILE A CB  1 
ATOM   1522 C CG1 . ILE A 1 202 ? 123.258 98.081  136.420 1.00 47.32  ? 202 ILE A CG1 1 
ATOM   1523 C CG2 . ILE A 1 202 ? 121.378 97.612  137.880 1.00 47.32  ? 202 ILE A CG2 1 
ATOM   1524 C CD1 . ILE A 1 202 ? 124.310 98.111  137.484 1.00 47.32  ? 202 ILE A CD1 1 
ATOM   1525 N N   . LYS A 1 203 ? 118.597 98.529  136.232 1.00 48.16  ? 203 LYS A N   1 
ATOM   1526 C CA  . LYS A 1 203 ? 117.295 98.916  136.753 1.00 48.16  ? 203 LYS A CA  1 
ATOM   1527 C C   . LYS A 1 203 ? 117.238 98.602  138.240 1.00 48.16  ? 203 LYS A C   1 
ATOM   1528 O O   . LYS A 1 203 ? 117.644 97.518  138.664 1.00 48.16  ? 203 LYS A O   1 
ATOM   1529 C CB  . LYS A 1 203 ? 116.174 98.190  136.016 1.00 48.16  ? 203 LYS A CB  1 
ATOM   1530 C CG  . LYS A 1 203 ? 114.790 98.622  136.438 1.00 48.16  ? 203 LYS A CG  1 
ATOM   1531 C CD  . LYS A 1 203 ? 113.717 97.957  135.599 1.00 48.16  ? 203 LYS A CD  1 
ATOM   1532 C CE  . LYS A 1 203 ? 112.332 98.402  136.040 1.00 48.16  ? 203 LYS A CE  1 
ATOM   1533 N NZ  . LYS A 1 203 ? 111.249 97.773  135.235 1.00 48.16  ? 203 LYS A NZ  1 
ATOM   1534 N N   . TYR A 1 204 ? 116.744 99.554  139.021 1.00 45.63  ? 204 TYR A N   1 
ATOM   1535 C CA  . TYR A 1 204 ? 116.680 99.491  140.473 1.00 45.63  ? 204 TYR A CA  1 
ATOM   1536 C C   . TYR A 1 204 ? 115.228 99.542  140.924 1.00 45.63  ? 204 TYR A C   1 
ATOM   1537 O O   . TYR A 1 204 ? 114.423 100.303 140.384 1.00 45.63  ? 204 TYR A O   1 
ATOM   1538 C CB  . TYR A 1 204 ? 117.447 100.659 141.063 1.00 45.63  ? 204 TYR A CB  1 
ATOM   1539 C CG  . TYR A 1 204 ? 118.935 100.530 140.960 1.00 45.63  ? 204 TYR A CG  1 
ATOM   1540 C CD1 . TYR A 1 204 ? 119.560 99.321  141.132 1.00 45.63  ? 204 TYR A CD1 1 
ATOM   1541 C CD2 . TYR A 1 204 ? 119.709 101.612 140.608 1.00 45.63  ? 204 TYR A CD2 1 
ATOM   1542 C CE1 . TYR A 1 204 ? 120.924 99.216  141.037 1.00 45.63  ? 204 TYR A CE1 1 
ATOM   1543 C CE2 . TYR A 1 204 ? 121.065 101.508 140.494 1.00 45.63  ? 204 TYR A CE2 1 
ATOM   1544 C CZ  . TYR A 1 204 ? 121.667 100.314 140.706 1.00 45.63  ? 204 TYR A CZ  1 
ATOM   1545 O OH  . TYR A 1 204 ? 123.023 100.221 140.588 1.00 45.63  ? 204 TYR A OH  1 
ATOM   1546 N N   . ASN A 1 205 ? 114.893 98.733  141.924 1.00 47.63  ? 205 ASN A N   1 
ATOM   1547 C CA  . ASN A 1 205 ? 113.497 98.621  142.329 1.00 47.63  ? 205 ASN A CA  1 
ATOM   1548 C C   . ASN A 1 205 ? 113.072 99.737  143.273 1.00 47.63  ? 205 ASN A C   1 
ATOM   1549 O O   . ASN A 1 205 ? 112.049 100.387 143.047 1.00 47.63  ? 205 ASN A O   1 
ATOM   1550 C CB  . ASN A 1 205 ? 113.240 97.266  142.988 1.00 47.63  ? 205 ASN A CB  1 
ATOM   1551 C CG  . ASN A 1 205 ? 113.260 96.130  141.999 1.00 47.63  ? 205 ASN A CG  1 
ATOM   1552 O OD1 . ASN A 1 205 ? 112.751 96.253  140.887 1.00 47.63  ? 205 ASN A OD1 1 
ATOM   1553 N ND2 . ASN A 1 205 ? 113.841 95.008  142.400 1.00 47.63  ? 205 ASN A ND2 1 
ATOM   1554 N N   . ASN A 1 206 ? 113.840 99.972  144.331 1.00 48.30  ? 206 ASN A N   1 
ATOM   1555 C CA  . ASN A 1 206 ? 113.479 100.933 145.361 1.00 48.30  ? 206 ASN A CA  1 
ATOM   1556 C C   . ASN A 1 206 ? 114.079 102.310 145.104 1.00 48.30  ? 206 ASN A C   1 
ATOM   1557 O O   . ASN A 1 206 ? 114.326 103.068 146.047 1.00 48.30  ? 206 ASN A O   1 
ATOM   1558 C CB  . ASN A 1 206 ? 113.914 100.409 146.724 1.00 48.30  ? 206 ASN A CB  1 
ATOM   1559 C CG  . ASN A 1 206 ? 113.188 99.153  147.111 1.00 48.30  ? 206 ASN A CG  1 
ATOM   1560 O OD1 . ASN A 1 206 ? 111.986 99.032  146.904 1.00 48.30  ? 206 ASN A OD1 1 
ATOM   1561 N ND2 . ASN A 1 206 ? 113.917 98.200  147.667 1.00 48.30  ? 206 ASN A ND2 1 
ATOM   1562 N N   . GLN A 1 207 ? 114.322 102.647 143.845 1.00 46.87  ? 207 GLN A N   1 
ATOM   1563 C CA  . GLN A 1 207 ? 114.952 103.904 143.482 1.00 46.87  ? 207 GLN A CA  1 
ATOM   1564 C C   . GLN A 1 207 ? 113.909 105.005 143.475 1.00 46.87  ? 207 GLN A C   1 
ATOM   1565 O O   . GLN A 1 207 ? 112.866 104.875 142.829 1.00 46.87  ? 207 GLN A O   1 
ATOM   1566 C CB  . GLN A 1 207 ? 115.606 103.791 142.108 1.00 46.87  ? 207 GLN A CB  1 
ATOM   1567 C CG  . GLN A 1 207 ? 116.456 104.967 141.678 1.00 46.87  ? 207 GLN A CG  1 
ATOM   1568 C CD  . GLN A 1 207 ? 116.977 104.778 140.280 1.00 46.87  ? 207 GLN A CD  1 
ATOM   1569 O OE1 . GLN A 1 207 ? 116.634 103.811 139.614 1.00 46.87  ? 207 GLN A OE1 1 
ATOM   1570 N NE2 . GLN A 1 207 ? 117.803 105.692 139.824 1.00 46.87  ? 207 GLN A NE2 1 
ATOM   1571 N N   . LEU A 1 208 ? 114.187 106.080 144.201 1.00 45.35  ? 208 LEU A N   1 
ATOM   1572 C CA  . LEU A 1 208 ? 113.353 107.271 144.197 1.00 45.35  ? 208 LEU A CA  1 
ATOM   1573 C C   . LEU A 1 208 ? 114.058 108.368 143.419 1.00 45.35  ? 208 LEU A C   1 
ATOM   1574 O O   . LEU A 1 208 ? 115.218 108.687 143.692 1.00 45.35  ? 208 LEU A O   1 
ATOM   1575 C CB  . LEU A 1 208 ? 113.051 107.742 145.614 1.00 45.35  ? 208 LEU A CB  1 
ATOM   1576 C CG  . LEU A 1 208 ? 112.170 106.816 146.428 1.00 45.35  ? 208 LEU A CG  1 
ATOM   1577 C CD1 . LEU A 1 208 ? 112.051 107.350 147.831 1.00 45.35  ? 208 LEU A CD1 1 
ATOM   1578 C CD2 . LEU A 1 208 ? 110.817 106.711 145.780 1.00 45.35  ? 208 LEU A CD2 1 
ATOM   1579 N N   . ALA A 1 209 ? 113.353 108.942 142.453 1.00 45.70  ? 209 ALA A N   1 
ATOM   1580 C CA  . ALA A 1 209 ? 113.917 109.995 141.632 1.00 45.70  ? 209 ALA A CA  1 
ATOM   1581 C C   . ALA A 1 209 ? 112.816 110.961 141.245 1.00 45.70  ? 209 ALA A C   1 
ATOM   1582 O O   . ALA A 1 209 ? 111.647 110.585 141.142 1.00 45.70  ? 209 ALA A O   1 
ATOM   1583 C CB  . ALA A 1 209 ? 114.593 109.433 140.377 1.00 45.70  ? 209 ALA A CB  1 
ATOM   1584 N N   . THR A 1 210 ? 113.203 112.215 141.045 1.00 45.99  ? 210 THR A N   1 
ATOM   1585 C CA  . THR A 1 210 ? 112.292 113.194 140.494 1.00 45.99  ? 210 THR A CA  1 
ATOM   1586 C C   . THR A 1 210 ? 112.149 112.969 138.992 1.00 45.99  ? 210 THR A C   1 
ATOM   1587 O O   . THR A 1 210 ? 112.905 112.223 138.370 1.00 45.99  ? 210 THR A O   1 
ATOM   1588 C CB  . THR A 1 210 ? 112.782 114.607 140.785 1.00 45.99  ? 210 THR A CB  1 
ATOM   1589 O OG1 . THR A 1 210 ? 114.016 114.834 140.107 1.00 45.99  ? 210 THR A OG1 1 
ATOM   1590 C CG2 . THR A 1 210 ? 113.014 114.783 142.260 1.00 45.99  ? 210 THR A CG2 1 
ATOM   1591 N N   . ARG A 1 211 ? 111.170 113.624 138.405 1.00 50.45  ? 211 ARG A N   1 
ATOM   1592 C CA  . ARG A 1 211 ? 110.794 113.340 137.037 1.00 50.45  ? 211 ARG A CA  1 
ATOM   1593 C C   . ARG A 1 211 ? 111.023 114.576 136.174 1.00 50.45  ? 211 ARG A C   1 
ATOM   1594 O O   . ARG A 1 211 ? 111.669 115.538 136.590 1.00 50.45  ? 211 ARG A O   1 
ATOM   1595 C CB  . ARG A 1 211 ? 109.344 112.870 136.993 1.00 50.45  ? 211 ARG A CB  1 
ATOM   1596 C CG  . ARG A 1 211 ? 109.112 111.571 137.730 1.00 50.45  ? 211 ARG A CG  1 
ATOM   1597 C CD  . ARG A 1 211 ? 107.641 111.182 137.731 1.00 50.45  ? 211 ARG A CD  1 
ATOM   1598 N NE  . ARG A 1 211 ? 107.144 110.906 136.386 1.00 50.45  ? 211 ARG A NE  1 
ATOM   1599 C CZ  . ARG A 1 211 ? 107.234 109.725 135.783 1.00 50.45  ? 211 ARG A CZ  1 
ATOM   1600 N NH1 . ARG A 1 211 ? 107.808 108.702 136.402 1.00 50.45  ? 211 ARG A NH1 1 
ATOM   1601 N NH2 . ARG A 1 211 ? 106.753 109.566 134.558 1.00 50.45  ? 211 ARG A NH2 1 
ATOM   1602 N N   . THR A 1 212 ? 110.518 114.523 134.946 1.00 49.68  ? 212 THR A N   1 
ATOM   1603 C CA  . THR A 1 212 ? 110.523 115.683 134.073 1.00 49.68  ? 212 THR A CA  1 
ATOM   1604 C C   . THR A 1 212 ? 109.598 116.758 134.621 1.00 49.68  ? 212 THR A C   1 
ATOM   1605 O O   . THR A 1 212 ? 108.626 116.474 135.326 1.00 49.68  ? 212 THR A O   1 
ATOM   1606 C CB  . THR A 1 212 ? 110.042 115.312 132.680 1.00 49.68  ? 212 THR A CB  1 
ATOM   1607 O OG1 . THR A 1 212 ? 108.645 115.016 132.741 1.00 49.68  ? 212 THR A OG1 1 
ATOM   1608 C CG2 . THR A 1 212 ? 110.756 114.091 132.190 1.00 49.68  ? 212 THR A CG2 1 
ATOM   1609 N N   . ALA A 1 213 ? 109.896 118.006 134.271 1.00 48.86  ? 213 ALA A N   1 
ATOM   1610 C CA  . ALA A 1 213 ? 108.998 119.105 134.587 1.00 48.86  ? 213 ALA A CA  1 
ATOM   1611 C C   . ALA A 1 213 ? 108.640 119.841 133.310 1.00 48.86  ? 213 ALA A C   1 
ATOM   1612 O O   . ALA A 1 213 ? 108.932 119.360 132.213 1.00 48.86  ? 213 ALA A O   1 
ATOM   1613 C CB  . ALA A 1 213 ? 109.636 120.055 135.594 1.00 48.86  ? 213 ALA A CB  1 
ATOM   1614 N N   . GLN A 1 214 ? 108.009 121.001 133.436 1.00 48.74  ? 214 GLN A N   1 
ATOM   1615 C CA  . GLN A 1 214 ? 107.759 121.832 132.274 1.00 48.74  ? 214 GLN A CA  1 
ATOM   1616 C C   . GLN A 1 214 ? 109.016 122.608 131.898 1.00 48.74  ? 214 GLN A C   1 
ATOM   1617 O O   . GLN A 1 214 ? 110.005 122.641 132.629 1.00 48.74  ? 214 GLN A O   1 
ATOM   1618 C CB  . GLN A 1 214 ? 106.593 122.776 132.532 1.00 48.74  ? 214 GLN A CB  1 
ATOM   1619 C CG  . GLN A 1 214 ? 105.246 122.089 132.528 1.00 48.74  ? 214 GLN A CG  1 
ATOM   1620 C CD  . GLN A 1 214 ? 104.904 121.447 133.844 1.00 48.74  ? 214 GLN A CD  1 
ATOM   1621 O OE1 . GLN A 1 214 ? 105.500 121.757 134.867 1.00 48.74  ? 214 GLN A OE1 1 
ATOM   1622 N NE2 . GLN A 1 214 ? 103.942 120.542 133.825 1.00 48.74  ? 214 GLN A NE2 1 
ATOM   1623 N N   . ALA A 1 215 ? 108.969 123.239 130.732 1.00 45.76  ? 215 ALA A N   1 
ATOM   1624 C CA  . ALA A 1 215 ? 110.156 123.870 130.184 1.00 45.76  ? 215 ALA A CA  1 
ATOM   1625 C C   . ALA A 1 215 ? 110.521 125.158 130.889 1.00 45.76  ? 215 ALA A C   1 
ATOM   1626 O O   . ALA A 1 215 ? 111.641 125.639 130.713 1.00 45.76  ? 215 ALA A O   1 
ATOM   1627 C CB  . ALA A 1 215 ? 109.964 124.140 128.694 1.00 45.76  ? 215 ALA A CB  1 
ATOM   1628 N N   . ILE A 1 216 ? 109.618 125.720 131.690 1.00 46.91  ? 216 ILE A N   1 
ATOM   1629 C CA  . ILE A 1 216 ? 109.923 126.944 132.418 1.00 46.91  ? 216 ILE A CA  1 
ATOM   1630 C C   . ILE A 1 216 ? 110.906 126.673 133.543 1.00 46.91  ? 216 ILE A C   1 
ATOM   1631 O O   . ILE A 1 216 ? 111.543 127.599 134.060 1.00 46.91  ? 216 ILE A O   1 
ATOM   1632 C CB  . ILE A 1 216 ? 108.626 127.579 132.943 1.00 46.91  ? 216 ILE A CB  1 
ATOM   1633 C CG1 . ILE A 1 216 ? 107.899 126.603 133.859 1.00 46.91  ? 216 ILE A CG1 1 
ATOM   1634 C CG2 . ILE A 1 216 ? 107.728 127.959 131.794 1.00 46.91  ? 216 ILE A CG2 1 
ATOM   1635 C CD1 . ILE A 1 216 ? 106.729 127.202 134.587 1.00 46.91  ? 216 ILE A CD1 1 
ATOM   1636 N N   . PHE A 1 217 ? 111.049 125.412 133.940 1.00 44.42  ? 217 PHE A N   1 
ATOM   1637 C CA  . PHE A 1 217 ? 111.968 125.009 134.985 1.00 44.42  ? 217 PHE A CA  1 
ATOM   1638 C C   . PHE A 1 217 ? 113.325 124.607 134.442 1.00 44.42  ? 217 PHE A C   1 
ATOM   1639 O O   . PHE A 1 217 ? 114.173 124.161 135.217 1.00 44.42  ? 217 PHE A O   1 
ATOM   1640 C CB  . PHE A 1 217 ? 111.370 123.853 135.764 1.00 44.42  ? 217 PHE A CB  1 
ATOM   1641 C CG  . PHE A 1 217 ? 110.044 124.165 136.366 1.00 44.42  ? 217 PHE A CG  1 
ATOM   1642 C CD1 . PHE A 1 217 ? 109.952 124.946 137.499 1.00 44.42  ? 217 PHE A CD1 1 
ATOM   1643 C CD2 . PHE A 1 217 ? 108.887 123.665 135.807 1.00 44.42  ? 217 PHE A CD2 1 
ATOM   1644 C CE1 . PHE A 1 217 ? 108.731 125.229 138.053 1.00 44.42  ? 217 PHE A CE1 1 
ATOM   1645 C CE2 . PHE A 1 217 ? 107.666 123.943 136.359 1.00 44.42  ? 217 PHE A CE2 1 
ATOM   1646 C CZ  . PHE A 1 217 ? 107.587 124.726 137.480 1.00 44.42  ? 217 PHE A CZ  1 
ATOM   1647 N N   . ASP A 1 218 ? 113.536 124.729 133.134 1.00 42.92  ? 218 ASP A N   1 
ATOM   1648 C CA  . ASP A 1 218 ? 114.815 124.383 132.538 1.00 42.92  ? 218 ASP A CA  1 
ATOM   1649 C C   . ASP A 1 218 ? 115.885 125.347 133.009 1.00 42.92  ? 218 ASP A C   1 
ATOM   1650 O O   . ASP A 1 218 ? 115.599 126.487 133.371 1.00 42.92  ? 218 ASP A O   1 
ATOM   1651 C CB  . ASP A 1 218 ? 114.740 124.431 131.016 1.00 42.92  ? 218 ASP A CB  1 
ATOM   1652 C CG  . ASP A 1 218 ? 113.905 123.334 130.439 1.00 42.92  ? 218 ASP A CG  1 
ATOM   1653 O OD1 . ASP A 1 218 ? 113.799 122.276 131.074 1.00 42.92  ? 218 ASP A OD1 1 
ATOM   1654 O OD2 . ASP A 1 218 ? 113.371 123.520 129.331 1.00 42.92  ? 218 ASP A OD2 1 
ATOM   1655 N N   . ASP A 1 219 ? 117.124 124.876 132.973 1.00 41.53  ? 219 ASP A N   1 
ATOM   1656 C CA  . ASP A 1 219 ? 118.295 125.524 133.540 1.00 41.53  ? 219 ASP A CA  1 
ATOM   1657 C C   . ASP A 1 219 ? 118.085 125.913 134.997 1.00 41.53  ? 219 ASP A C   1 
ATOM   1658 O O   . ASP A 1 219 ? 118.047 127.106 135.315 1.00 41.53  ? 219 ASP A O   1 
ATOM   1659 C CB  . ASP A 1 219 ? 118.719 126.757 132.748 1.00 41.53  ? 219 ASP A CB  1 
ATOM   1660 C CG  . ASP A 1 219 ? 120.111 127.198 133.087 1.00 41.53  ? 219 ASP A CG  1 
ATOM   1661 O OD1 . ASP A 1 219 ? 120.857 126.407 133.697 1.00 41.53  ? 219 ASP A OD1 1 
ATOM   1662 O OD2 . ASP A 1 219 ? 120.415 128.377 132.853 1.00 41.53  ? 219 ASP A OD2 1 
ATOM   1663 N N   . SER A 1 220 ? 117.887 124.947 135.890 1.00 37.90  ? 220 SER A N   1 
ATOM   1664 C CA  . SER A 1 220 ? 117.711 125.295 137.289 1.00 37.90  ? 220 SER A CA  1 
ATOM   1665 C C   . SER A 1 220 ? 118.787 124.656 138.150 1.00 37.90  ? 220 SER A C   1 
ATOM   1666 O O   . SER A 1 220 ? 119.069 125.142 139.248 1.00 37.90  ? 220 SER A O   1 
ATOM   1667 C CB  . SER A 1 220 ? 116.315 124.900 137.751 1.00 37.90  ? 220 SER A CB  1 
ATOM   1668 O OG  . SER A 1 220 ? 116.123 123.509 137.687 1.00 37.90  ? 220 SER A OG  1 
ATOM   1669 N N   . TYR A 1 221 ? 119.406 123.582 137.652 1.00 37.35  ? 221 TYR A N   1 
ATOM   1670 C CA  . TYR A 1 221 ? 120.476 122.810 138.288 1.00 37.35  ? 221 TYR A CA  1 
ATOM   1671 C C   . TYR A 1 221 ? 120.048 122.200 139.613 1.00 37.35  ? 221 TYR A C   1 
ATOM   1672 O O   . TYR A 1 221 ? 120.681 122.461 140.636 1.00 37.35  ? 221 TYR A O   1 
ATOM   1673 C CB  . TYR A 1 221 ? 121.742 123.643 138.544 1.00 37.35  ? 221 TYR A CB  1 
ATOM   1674 C CG  . TYR A 1 221 ? 122.487 124.158 137.339 1.00 37.35  ? 221 TYR A CG  1 
ATOM   1675 C CD1 . TYR A 1 221 ? 122.184 123.732 136.061 1.00 37.35  ? 221 TYR A CD1 1 
ATOM   1676 C CD2 . TYR A 1 221 ? 123.525 125.061 137.497 1.00 37.35  ? 221 TYR A CD2 1 
ATOM   1677 C CE1 . TYR A 1 221 ? 122.874 124.208 134.981 1.00 37.35  ? 221 TYR A CE1 1 
ATOM   1678 C CE2 . TYR A 1 221 ? 124.220 125.532 136.424 1.00 37.35  ? 221 TYR A CE2 1 
ATOM   1679 C CZ  . TYR A 1 221 ? 123.888 125.108 135.170 1.00 37.35  ? 221 TYR A CZ  1 
ATOM   1680 O OH  . TYR A 1 221 ? 124.590 125.577 134.091 1.00 37.35  ? 221 TYR A OH  1 
ATOM   1681 N N   . LEU A 1 222 ? 118.998 121.390 139.615 1.00 36.66  ? 222 LEU A N   1 
ATOM   1682 C CA  . LEU A 1 222 ? 118.605 120.688 140.828 1.00 36.66  ? 222 LEU A CA  1 
ATOM   1683 C C   . LEU A 1 222 ? 119.621 119.600 141.131 1.00 36.66  ? 222 LEU A C   1 
ATOM   1684 O O   . LEU A 1 222 ? 120.047 118.873 140.238 1.00 36.66  ? 222 LEU A O   1 
ATOM   1685 C CB  . LEU A 1 222 ? 117.217 120.094 140.652 1.00 36.66  ? 222 LEU A CB  1 
ATOM   1686 C CG  . LEU A 1 222 ? 116.380 119.529 141.779 1.00 36.66  ? 222 LEU A CG  1 
ATOM   1687 C CD1 . LEU A 1 222 ? 114.967 119.731 141.400 1.00 36.66  ? 222 LEU A CD1 1 
ATOM   1688 C CD2 . LEU A 1 222 ? 116.583 118.101 141.867 1.00 36.66  ? 222 LEU A CD2 1 
ATOM   1689 N N   . GLY A 1 223 ? 120.014 119.479 142.385 1.00 35.73  ? 223 GLY A N   1 
ATOM   1690 C CA  . GLY A 1 223 ? 121.068 118.556 142.721 1.00 35.73  ? 223 GLY A CA  1 
ATOM   1691 C C   . GLY A 1 223 ? 122.449 119.127 142.591 1.00 35.73  ? 223 GLY A C   1 
ATOM   1692 O O   . GLY A 1 223 ? 123.419 118.369 142.594 1.00 35.73  ? 223 GLY A O   1 
ATOM   1693 N N   . TYR A 1 224 ? 122.569 120.439 142.465 1.00 35.54  ? 224 TYR A N   1 
ATOM   1694 C CA  . TYR A 1 224 ? 123.872 121.075 142.515 1.00 35.54  ? 224 TYR A CA  1 
ATOM   1695 C C   . TYR A 1 224 ? 124.486 120.941 143.902 1.00 35.54  ? 224 TYR A C   1 
ATOM   1696 O O   . TYR A 1 224 ? 125.711 120.850 144.035 1.00 35.54  ? 224 TYR A O   1 
ATOM   1697 C CB  . TYR A 1 224 ? 123.714 122.538 142.137 1.00 35.54  ? 224 TYR A CB  1 
ATOM   1698 C CG  . TYR A 1 224 ? 124.979 123.288 141.845 1.00 35.54  ? 224 TYR A CG  1 
ATOM   1699 C CD1 . TYR A 1 224 ? 125.524 123.285 140.579 1.00 35.54  ? 224 TYR A CD1 1 
ATOM   1700 C CD2 . TYR A 1 224 ? 125.625 123.992 142.830 1.00 35.54  ? 224 TYR A CD2 1 
ATOM   1701 C CE1 . TYR A 1 224 ? 126.669 123.970 140.309 1.00 35.54  ? 224 TYR A CE1 1 
ATOM   1702 C CE2 . TYR A 1 224 ? 126.764 124.656 142.570 1.00 35.54  ? 224 TYR A CE2 1 
ATOM   1703 C CZ  . TYR A 1 224 ? 127.284 124.654 141.314 1.00 35.54  ? 224 TYR A CZ  1 
ATOM   1704 O OH  . TYR A 1 224 ? 128.439 125.347 141.066 1.00 35.54  ? 224 TYR A OH  1 
ATOM   1705 N N   . SER A 1 225 ? 123.648 120.924 144.939 1.00 35.96  ? 225 SER A N   1 
ATOM   1706 C CA  . SER A 1 225 ? 124.045 120.659 146.311 1.00 35.96  ? 225 SER A CA  1 
ATOM   1707 C C   . SER A 1 225 ? 122.919 119.893 146.980 1.00 35.96  ? 225 SER A C   1 
ATOM   1708 O O   . SER A 1 225 ? 121.751 120.126 146.674 1.00 35.96  ? 225 SER A O   1 
ATOM   1709 C CB  . SER A 1 225 ? 124.323 121.949 147.062 1.00 35.96  ? 225 SER A CB  1 
ATOM   1710 O OG  . SER A 1 225 ? 125.410 122.622 146.473 1.00 35.96  ? 225 SER A OG  1 
ATOM   1711 N N   . VAL A 1 226 ? 123.266 118.962 147.873 1.00 37.97  ? 226 VAL A N   1 
ATOM   1712 C CA  . VAL A 1 226 ? 122.292 118.121 148.562 1.00 37.97  ? 226 VAL A CA  1 
ATOM   1713 C C   . VAL A 1 226 ? 122.554 118.177 150.061 1.00 37.97  ? 226 VAL A C   1 
ATOM   1714 O O   . VAL A 1 226 ? 123.626 118.574 150.516 1.00 37.97  ? 226 VAL A O   1 
ATOM   1715 C CB  . VAL A 1 226 ? 122.319 116.656 148.078 1.00 37.97  ? 226 VAL A CB  1 
ATOM   1716 C CG1 . VAL A 1 226 ? 121.953 116.552 146.627 1.00 37.97  ? 226 VAL A CG1 1 
ATOM   1717 C CG2 . VAL A 1 226 ? 123.668 116.060 148.300 1.00 37.97  ? 226 VAL A CG2 1 
ATOM   1718 N N   . ALA A 1 227 ? 121.547 117.761 150.828 1.00 39.10  ? 227 ALA A N   1 
ATOM   1719 C CA  . ALA A 1 227 ? 121.652 117.594 152.271 1.00 39.10  ? 227 ALA A CA  1 
ATOM   1720 C C   . ALA A 1 227 ? 120.559 116.638 152.708 1.00 39.10  ? 227 ALA A C   1 
ATOM   1721 O O   . ALA A 1 227 ? 119.628 116.361 151.955 1.00 39.10  ? 227 ALA A O   1 
ATOM   1722 C CB  . ALA A 1 227 ? 121.527 118.922 153.013 1.00 39.10  ? 227 ALA A CB  1 
ATOM   1723 N N   . VAL A 1 228 ? 120.688 116.119 153.926 1.00 41.84  ? 228 VAL A N   1 
ATOM   1724 C CA  . VAL A 1 228 ? 119.658 115.282 154.535 1.00 41.84  ? 228 VAL A CA  1 
ATOM   1725 C C   . VAL A 1 228 ? 119.359 115.774 155.947 1.00 41.84  ? 228 VAL A C   1 
ATOM   1726 O O   . VAL A 1 228 ? 120.224 116.338 156.625 1.00 41.84  ? 228 VAL A O   1 
ATOM   1727 C CB  . VAL A 1 228 ? 120.042 113.789 154.554 1.00 41.84  ? 228 VAL A CB  1 
ATOM   1728 C CG1 . VAL A 1 228 ? 120.011 113.207 153.167 1.00 41.84  ? 228 VAL A CG1 1 
ATOM   1729 C CG2 . VAL A 1 228 ? 121.409 113.604 155.153 1.00 41.84  ? 228 VAL A CG2 1 
ATOM   1730 N N   . GLY A 1 229 ? 118.124 115.555 156.381 1.00 41.94  ? 229 GLY A N   1 
ATOM   1731 C CA  . GLY A 1 229 ? 117.629 115.968 157.678 1.00 41.94  ? 229 GLY A CA  1 
ATOM   1732 C C   . GLY A 1 229 ? 116.140 115.714 157.706 1.00 41.94  ? 229 GLY A C   1 
ATOM   1733 O O   . GLY A 1 229 ? 115.529 115.625 156.641 1.00 41.94  ? 229 GLY A O   1 
ATOM   1734 N N   . ASP A 1 230 ? 115.537 115.571 158.878 1.00 41.00  ? 230 ASP A N   1 
ATOM   1735 C CA  . ASP A 1 230 ? 114.125 115.230 158.942 1.00 41.00  ? 230 ASP A CA  1 
ATOM   1736 C C   . ASP A 1 230 ? 113.291 116.499 159.001 1.00 41.00  ? 230 ASP A C   1 
ATOM   1737 O O   . ASP A 1 230 ? 113.610 117.422 159.753 1.00 41.00  ? 230 ASP A O   1 
ATOM   1738 C CB  . ASP A 1 230 ? 113.839 114.363 160.159 1.00 41.00  ? 230 ASP A CB  1 
ATOM   1739 C CG  . ASP A 1 230 ? 112.491 113.682 160.089 1.00 41.00  ? 230 ASP A CG  1 
ATOM   1740 O OD1 . ASP A 1 230 ? 111.794 113.793 159.061 1.00 41.00  ? 230 ASP A OD1 1 
ATOM   1741 O OD2 . ASP A 1 230 ? 112.120 113.035 161.083 1.00 41.00  ? 230 ASP A OD2 1 
ATOM   1742 N N   . PHE A 1 231 ? 112.212 116.542 158.216 1.00 38.39  ? 231 PHE A N   1 
ATOM   1743 C CA  . PHE A 1 231 ? 111.405 117.743 158.108 1.00 38.39  ? 231 PHE A CA  1 
ATOM   1744 C C   . PHE A 1 231 ? 109.906 117.502 158.138 1.00 38.39  ? 231 PHE A C   1 
ATOM   1745 O O   . PHE A 1 231 ? 109.150 118.458 157.956 1.00 38.39  ? 231 PHE A O   1 
ATOM   1746 C CB  . PHE A 1 231 ? 111.772 118.515 156.836 1.00 38.39  ? 231 PHE A CB  1 
ATOM   1747 C CG  . PHE A 1 231 ? 113.106 119.162 156.911 1.00 38.39  ? 231 PHE A CG  1 
ATOM   1748 C CD1 . PHE A 1 231 ? 113.253 120.365 157.526 1.00 38.39  ? 231 PHE A CD1 1 
ATOM   1749 C CD2 . PHE A 1 231 ? 114.216 118.541 156.413 1.00 38.39  ? 231 PHE A CD2 1 
ATOM   1750 C CE1 . PHE A 1 231 ? 114.476 120.944 157.621 1.00 38.39  ? 231 PHE A CE1 1 
ATOM   1751 C CE2 . PHE A 1 231 ? 115.440 119.120 156.515 1.00 38.39  ? 231 PHE A CE2 1 
ATOM   1752 C CZ  . PHE A 1 231 ? 115.570 120.318 157.115 1.00 38.39  ? 231 PHE A CZ  1 
ATOM   1753 N N   . ASN A 1 232 ? 109.446 116.277 158.359 1.00 40.87  ? 232 ASN A N   1 
ATOM   1754 C CA  . ASN A 1 232 ? 108.043 116.102 158.708 1.00 40.87  ? 232 ASN A CA  1 
ATOM   1755 C C   . ASN A 1 232 ? 107.844 115.033 159.772 1.00 40.87  ? 232 ASN A C   1 
ATOM   1756 O O   . ASN A 1 232 ? 106.784 114.403 159.826 1.00 40.87  ? 232 ASN A O   1 
ATOM   1757 C CB  . ASN A 1 232 ? 107.168 115.812 157.480 1.00 40.87  ? 232 ASN A CB  1 
ATOM   1758 C CG  . ASN A 1 232 ? 107.596 114.598 156.704 1.00 40.87  ? 232 ASN A CG  1 
ATOM   1759 O OD1 . ASN A 1 232 ? 108.552 113.923 157.043 1.00 40.87  ? 232 ASN A OD1 1 
ATOM   1760 N ND2 . ASN A 1 232 ? 106.870 114.311 155.644 1.00 40.87  ? 232 ASN A ND2 1 
ATOM   1761 N N   . GLY A 1 233 ? 108.850 114.803 160.609 1.00 42.28  ? 233 GLY A N   1 
ATOM   1762 C CA  . GLY A 1 233 ? 108.682 113.984 161.792 1.00 42.28  ? 233 GLY A CA  1 
ATOM   1763 C C   . GLY A 1 233 ? 108.496 112.501 161.571 1.00 42.28  ? 233 GLY A C   1 
ATOM   1764 O O   . GLY A 1 233 ? 108.150 111.792 162.519 1.00 42.28  ? 233 GLY A O   1 
ATOM   1765 N N   . ASP A 1 234 ? 108.717 111.998 160.360 1.00 43.60  ? 234 ASP A N   1 
ATOM   1766 C CA  . ASP A 1 234 ? 108.580 110.568 160.119 1.00 43.60  ? 234 ASP A CA  1 
ATOM   1767 C C   . ASP A 1 234 ? 109.827 109.778 160.480 1.00 43.60  ? 234 ASP A C   1 
ATOM   1768 O O   . ASP A 1 234 ? 109.873 108.580 160.196 1.00 43.60  ? 234 ASP A O   1 
ATOM   1769 C CB  . ASP A 1 234 ? 108.187 110.314 158.660 1.00 43.60  ? 234 ASP A CB  1 
ATOM   1770 C CG  . ASP A 1 234 ? 109.153 110.937 157.651 1.00 43.60  ? 234 ASP A CG  1 
ATOM   1771 O OD1 . ASP A 1 234 ? 110.115 111.643 158.030 1.00 43.60  ? 234 ASP A OD1 1 
ATOM   1772 O OD2 . ASP A 1 234 ? 108.934 110.728 156.441 1.00 43.60  ? 234 ASP A OD2 1 
ATOM   1773 N N   . GLY A 1 235 ? 110.833 110.408 161.084 1.00 43.39  ? 235 GLY A N   1 
ATOM   1774 C CA  . GLY A 1 235 ? 112.047 109.736 161.483 1.00 43.39  ? 235 GLY A CA  1 
ATOM   1775 C C   . GLY A 1 235 ? 113.041 109.488 160.378 1.00 43.39  ? 235 GLY A C   1 
ATOM   1776 O O   . GLY A 1 235 ? 114.170 109.081 160.669 1.00 43.39  ? 235 GLY A O   1 
ATOM   1777 N N   . ILE A 1 236 ? 112.673 109.740 159.126 1.00 43.97  ? 236 ILE A N   1 
ATOM   1778 C CA  . ILE A 1 236 ? 113.481 109.427 157.956 1.00 43.97  ? 236 ILE A CA  1 
ATOM   1779 C C   . ILE A 1 236 ? 114.104 110.724 157.461 1.00 43.97  ? 236 ILE A C   1 
ATOM   1780 O O   . ILE A 1 236 ? 113.460 111.777 157.506 1.00 43.97  ? 236 ILE A O   1 
ATOM   1781 C CB  . ILE A 1 236 ? 112.598 108.781 156.872 1.00 43.97  ? 236 ILE A CB  1 
ATOM   1782 C CG1 . ILE A 1 236 ? 111.819 107.614 157.461 1.00 43.97  ? 236 ILE A CG1 1 
ATOM   1783 C CG2 . ILE A 1 236 ? 113.428 108.259 155.725 1.00 43.97  ? 236 ILE A CG2 1 
ATOM   1784 C CD1 . ILE A 1 236 ? 110.730 107.123 156.564 1.00 43.97  ? 236 ILE A CD1 1 
ATOM   1785 N N   . ASP A 1 237 ? 115.360 110.659 157.019 1.00 43.56  ? 237 ASP A N   1 
ATOM   1786 C CA  . ASP A 1 237 ? 116.014 111.832 156.460 1.00 43.56  ? 237 ASP A CA  1 
ATOM   1787 C C   . ASP A 1 237 ? 115.332 112.264 155.179 1.00 43.56  ? 237 ASP A C   1 
ATOM   1788 O O   . ASP A 1 237 ? 115.386 111.562 154.167 1.00 43.56  ? 237 ASP A O   1 
ATOM   1789 C CB  . ASP A 1 237 ? 117.484 111.564 156.178 1.00 43.56  ? 237 ASP A CB  1 
ATOM   1790 C CG  . ASP A 1 237 ? 118.325 111.636 157.399 1.00 43.56  ? 237 ASP A CG  1 
ATOM   1791 O OD1 . ASP A 1 237 ? 117.936 112.352 158.335 1.00 43.56  ? 237 ASP A OD1 1 
ATOM   1792 O OD2 . ASP A 1 237 ? 119.396 111.011 157.413 1.00 43.56  ? 237 ASP A OD2 1 
ATOM   1793 N N   . ASP A 1 238 ? 114.695 113.423 155.232 1.00 42.60  ? 238 ASP A N   1 
ATOM   1794 C CA  . ASP A 1 238 ? 114.100 114.041 154.065 1.00 42.60  ? 238 ASP A CA  1 
ATOM   1795 C C   . ASP A 1 238 ? 115.196 114.733 153.262 1.00 42.60  ? 238 ASP A C   1 
ATOM   1796 O O   . ASP A 1 238 ? 116.223 115.146 153.807 1.00 42.60  ? 238 ASP A O   1 
ATOM   1797 C CB  . ASP A 1 238 ? 113.024 115.027 154.498 1.00 42.60  ? 238 ASP A CB  1 
ATOM   1798 C CG  . ASP A 1 238 ? 111.960 114.379 155.352 1.00 42.60  ? 238 ASP A CG  1 
ATOM   1799 O OD1 . ASP A 1 238 ? 111.762 113.154 155.271 1.00 42.60  ? 238 ASP A OD1 1 
ATOM   1800 O OD2 . ASP A 1 238 ? 111.307 115.099 156.114 1.00 42.60  ? 238 ASP A OD2 1 
ATOM   1801 N N   . PHE A 1 239 ? 114.975 114.850 151.953 1.00 41.68  ? 239 PHE A N   1 
ATOM   1802 C CA  . PHE A 1 239 ? 116.023 115.262 151.026 1.00 41.68  ? 239 PHE A CA  1 
ATOM   1803 C C   . PHE A 1 239 ? 115.966 116.762 150.792 1.00 41.68  ? 239 PHE A C   1 
ATOM   1804 O O   . PHE A 1 239 ? 114.942 117.283 150.349 1.00 41.68  ? 239 PHE A O   1 
ATOM   1805 C CB  . PHE A 1 239 ? 115.900 114.545 149.686 1.00 41.68  ? 239 PHE A CB  1 
ATOM   1806 C CG  . PHE A 1 239 ? 115.868 113.060 149.800 1.00 41.68  ? 239 PHE A CG  1 
ATOM   1807 C CD1 . PHE A 1 239 ? 116.948 112.367 150.301 1.00 41.68  ? 239 PHE A CD1 1 
ATOM   1808 C CD2 . PHE A 1 239 ? 114.776 112.351 149.345 1.00 41.68  ? 239 PHE A CD2 1 
ATOM   1809 C CE1 . PHE A 1 239 ? 116.923 111.004 150.386 1.00 41.68  ? 239 PHE A CE1 1 
ATOM   1810 C CE2 . PHE A 1 239 ? 114.749 110.989 149.420 1.00 41.68  ? 239 PHE A CE2 1 
ATOM   1811 C CZ  . PHE A 1 239 ? 115.817 110.315 149.945 1.00 41.68  ? 239 PHE A CZ  1 
ATOM   1812 N N   . VAL A 1 240 ? 117.070 117.442 151.065 1.00 38.69  ? 240 VAL A N   1 
ATOM   1813 C CA  . VAL A 1 240 ? 117.215 118.869 150.821 1.00 38.69  ? 240 VAL A CA  1 
ATOM   1814 C C   . VAL A 1 240 ? 118.126 119.039 149.617 1.00 38.69  ? 240 VAL A C   1 
ATOM   1815 O O   . VAL A 1 240 ? 119.122 118.324 149.488 1.00 38.69  ? 240 VAL A O   1 
ATOM   1816 C CB  . VAL A 1 240 ? 117.795 119.570 152.062 1.00 38.69  ? 240 VAL A CB  1 
ATOM   1817 C CG1 . VAL A 1 240 ? 117.921 121.065 151.855 1.00 38.69  ? 240 VAL A CG1 1 
ATOM   1818 C CG2 . VAL A 1 240 ? 116.951 119.265 153.262 1.00 38.69  ? 240 VAL A CG2 1 
ATOM   1819 N N   . SER A 1 241 ? 117.782 119.965 148.725 1.00 37.40  ? 241 SER A N   1 
ATOM   1820 C CA  . SER A 1 241 ? 118.554 120.151 147.503 1.00 37.40  ? 241 SER A CA  1 
ATOM   1821 C C   . SER A 1 241 ? 118.646 121.630 147.170 1.00 37.40  ? 241 SER A C   1 
ATOM   1822 O O   . SER A 1 241 ? 117.623 122.311 147.138 1.00 37.40  ? 241 SER A O   1 
ATOM   1823 C CB  . SER A 1 241 ? 117.916 119.387 146.347 1.00 37.40  ? 241 SER A CB  1 
ATOM   1824 O OG  . SER A 1 241 ? 118.627 119.610 145.148 1.00 37.40  ? 241 SER A OG  1 
ATOM   1825 N N   . GLY A 1 242 ? 119.857 122.120 146.913 1.00 35.73  ? 242 GLY A N   1 
ATOM   1826 C CA  . GLY A 1 242 ? 120.024 123.490 146.455 1.00 35.73  ? 242 GLY A CA  1 
ATOM   1827 C C   . GLY A 1 242 ? 119.915 123.589 144.940 1.00 35.73  ? 242 GLY A C   1 
ATOM   1828 O O   . GLY A 1 242 ? 120.599 122.886 144.198 1.00 35.73  ? 242 GLY A O   1 
ATOM   1829 N N   . VAL A 1 243 ? 119.033 124.479 144.483 1.00 34.27  ? 243 VAL A N   1 
ATOM   1830 C CA  . VAL A 1 243 ? 118.681 124.626 143.070 1.00 34.27  ? 243 VAL A CA  1 
ATOM   1831 C C   . VAL A 1 243 ? 119.048 126.044 142.644 1.00 34.27  ? 243 VAL A C   1 
ATOM   1832 O O   . VAL A 1 243 ? 118.198 126.939 142.706 1.00 34.27  ? 243 VAL A O   1 
ATOM   1833 C CB  . VAL A 1 243 ? 117.187 124.349 142.860 1.00 34.27  ? 243 VAL A CB  1 
ATOM   1834 C CG1 . VAL A 1 243 ? 116.859 124.257 141.421 1.00 34.27  ? 243 VAL A CG1 1 
ATOM   1835 C CG2 . VAL A 1 243 ? 116.765 123.098 143.566 1.00 34.27  ? 243 VAL A CG2 1 
ATOM   1836 N N   . PRO A 1 244 ? 120.285 126.302 142.206 1.00 33.57  ? 244 PRO A N   1 
ATOM   1837 C CA  . PRO A 1 244 ? 120.807 127.670 142.229 1.00 33.57  ? 244 PRO A CA  1 
ATOM   1838 C C   . PRO A 1 244 ? 120.268 128.590 141.165 1.00 33.57  ? 244 PRO A C   1 
ATOM   1839 O O   . PRO A 1 244 ? 120.401 129.807 141.320 1.00 33.57  ? 244 PRO A O   1 
ATOM   1840 C CB  . PRO A 1 244 ? 122.303 127.467 142.029 1.00 33.57  ? 244 PRO A CB  1 
ATOM   1841 C CG  . PRO A 1 244 ? 122.560 126.136 142.397 1.00 33.57  ? 244 PRO A CG  1 
ATOM   1842 C CD  . PRO A 1 244 ? 121.374 125.349 142.000 1.00 33.57  ? 244 PRO A CD  1 
ATOM   1843 N N   . ARG A 1 245 ? 119.691 128.079 140.085 1.00 36.84  ? 245 ARG A N   1 
ATOM   1844 C CA  . ARG A 1 245 ? 119.230 128.938 139.004 1.00 36.84  ? 245 ARG A CA  1 
ATOM   1845 C C   . ARG A 1 245 ? 117.727 128.884 138.797 1.00 36.84  ? 245 ARG A C   1 
ATOM   1846 O O   . ARG A 1 245 ? 117.248 129.321 137.750 1.00 36.84  ? 245 ARG A O   1 
ATOM   1847 C CB  . ARG A 1 245 ? 119.928 128.574 137.694 1.00 36.84  ? 245 ARG A CB  1 
ATOM   1848 C CG  . ARG A 1 245 ? 121.401 128.894 137.631 1.00 36.84  ? 245 ARG A CG  1 
ATOM   1849 C CD  . ARG A 1 245 ? 121.970 128.459 136.288 1.00 36.84  ? 245 ARG A CD  1 
ATOM   1850 N NE  . ARG A 1 245 ? 121.450 129.239 135.166 1.00 36.84  ? 245 ARG A NE  1 
ATOM   1851 C CZ  . ARG A 1 245 ? 122.044 130.313 134.656 1.00 36.84  ? 245 ARG A CZ  1 
ATOM   1852 N NH1 . ARG A 1 245 ? 123.194 130.737 135.154 1.00 36.84  ? 245 ARG A NH1 1 
ATOM   1853 N NH2 . ARG A 1 245 ? 121.494 130.954 133.638 1.00 36.84  ? 245 ARG A NH2 1 
ATOM   1854 N N   . ALA A 1 246 ? 116.970 128.358 139.747 1.00 36.06  ? 246 ALA A N   1 
ATOM   1855 C CA  . ALA A 1 246 ? 115.536 128.298 139.557 1.00 36.06  ? 246 ALA A CA  1 
ATOM   1856 C C   . ALA A 1 246 ? 114.907 129.645 139.865 1.00 36.06  ? 246 ALA A C   1 
ATOM   1857 O O   . ALA A 1 246 ? 115.526 130.517 140.478 1.00 36.06  ? 246 ALA A O   1 
ATOM   1858 C CB  . ALA A 1 246 ? 114.912 127.230 140.441 1.00 36.06  ? 246 ALA A CB  1 
ATOM   1859 N N   . ALA A 1 247 ? 113.657 129.792 139.423 1.00 38.18  ? 247 ALA A N   1 
ATOM   1860 C CA  . ALA A 1 247 ? 112.813 130.971 139.632 1.00 38.18  ? 247 ALA A CA  1 
ATOM   1861 C C   . ALA A 1 247 ? 113.484 132.240 139.111 1.00 38.18  ? 247 ALA A C   1 
ATOM   1862 O O   . ALA A 1 247 ? 113.624 133.236 139.822 1.00 38.18  ? 247 ALA A O   1 
ATOM   1863 C CB  . ALA A 1 247 ? 112.414 131.119 141.103 1.00 38.18  ? 247 ALA A CB  1 
ATOM   1864 N N   . ARG A 1 248 ? 113.900 132.159 137.844 1.00 38.03  ? 248 ARG A N   1 
ATOM   1865 C CA  . ARG A 1 248 ? 114.553 133.238 137.097 1.00 38.03  ? 248 ARG A CA  1 
ATOM   1866 C C   . ARG A 1 248 ? 115.812 133.718 137.803 1.00 38.03  ? 248 ARG A C   1 
ATOM   1867 O O   . ARG A 1 248 ? 115.998 134.904 138.052 1.00 38.03  ? 248 ARG A O   1 
ATOM   1868 C CB  . ARG A 1 248 ? 113.589 134.394 136.832 1.00 38.03  ? 248 ARG A CB  1 
ATOM   1869 C CG  . ARG A 1 248 ? 112.397 133.992 135.992 1.00 38.03  ? 248 ARG A CG  1 
ATOM   1870 C CD  . ARG A 1 248 ? 111.449 135.146 135.765 1.00 38.03  ? 248 ARG A CD  1 
ATOM   1871 N NE  . ARG A 1 248 ? 112.031 136.169 134.909 1.00 38.03  ? 248 ARG A NE  1 
ATOM   1872 C CZ  . ARG A 1 248 ? 112.363 137.385 135.321 1.00 38.03  ? 248 ARG A CZ  1 
ATOM   1873 N NH1 . ARG A 1 248 ? 112.165 137.737 136.582 1.00 38.03  ? 248 ARG A NH1 1 
ATOM   1874 N NH2 . ARG A 1 248 ? 112.885 138.249 134.470 1.00 38.03  ? 248 ARG A NH2 1 
ATOM   1875 N N   . THR A 1 249 ? 116.648 132.755 138.171 1.00 35.90  ? 249 THR A N   1 
ATOM   1876 C CA  . THR A 1 249 ? 118.006 132.906 138.681 1.00 35.90  ? 249 THR A CA  1 
ATOM   1877 C C   . THR A 1 249 ? 118.045 133.635 140.026 1.00 35.90  ? 249 THR A C   1 
ATOM   1878 O O   . THR A 1 249 ? 119.094 134.142 140.438 1.00 35.90  ? 249 THR A O   1 
ATOM   1879 C CB  . THR A 1 249 ? 118.892 133.578 137.623 1.00 35.90  ? 249 THR A CB  1 
ATOM   1880 O OG1 . THR A 1 249 ? 118.489 133.094 136.340 1.00 35.90  ? 249 THR A OG1 1 
ATOM   1881 C CG2 . THR A 1 249 ? 120.315 133.133 137.736 1.00 35.90  ? 249 THR A CG2 1 
ATOM   1882 N N   . LEU A 1 250 ? 116.924 133.691 140.746 1.00 34.75  ? 250 LEU A N   1 
ATOM   1883 C CA  . LEU A 1 250 ? 116.982 134.039 142.161 1.00 34.75  ? 250 LEU A CA  1 
ATOM   1884 C C   . LEU A 1 250 ? 117.633 132.929 142.964 1.00 34.75  ? 250 LEU A C   1 
ATOM   1885 O O   . LEU A 1 250 ? 118.373 133.201 143.911 1.00 34.75  ? 250 LEU A O   1 
ATOM   1886 C CB  . LEU A 1 250 ? 115.583 134.300 142.707 1.00 34.75  ? 250 LEU A CB  1 
ATOM   1887 C CG  . LEU A 1 250 ? 114.798 135.526 142.283 1.00 34.75  ? 250 LEU A CG  1 
ATOM   1888 C CD1 . LEU A 1 250 ? 113.369 135.352 142.702 1.00 34.75  ? 250 LEU A CD1 1 
ATOM   1889 C CD2 . LEU A 1 250 ? 115.375 136.718 142.968 1.00 34.75  ? 250 LEU A CD2 1 
ATOM   1890 N N   . GLY A 1 251 ? 117.383 131.690 142.590 1.00 34.34  ? 251 GLY A N   1 
ATOM   1891 C CA  . GLY A 1 251 ? 117.787 130.516 143.324 1.00 34.34  ? 251 GLY A CA  1 
ATOM   1892 C C   . GLY A 1 251 ? 116.664 129.999 144.195 1.00 34.34  ? 251 GLY A C   1 
ATOM   1893 O O   . GLY A 1 251 ? 115.915 130.760 144.811 1.00 34.34  ? 251 GLY A O   1 
ATOM   1894 N N   . MET A 1 252 ? 116.519 128.680 144.228 1.00 35.54  ? 252 MET A N   1 
ATOM   1895 C CA  . MET A 1 252 ? 115.609 128.036 145.158 1.00 35.54  ? 252 MET A CA  1 
ATOM   1896 C C   . MET A 1 252 ? 116.341 126.911 145.874 1.00 35.54  ? 252 MET A C   1 
ATOM   1897 O O   . MET A 1 252 ? 117.449 126.528 145.501 1.00 35.54  ? 252 MET A O   1 
ATOM   1898 C CB  . MET A 1 252 ? 114.354 127.512 144.459 1.00 35.54  ? 252 MET A CB  1 
ATOM   1899 C CG  . MET A 1 252 ? 113.457 128.605 143.981 1.00 35.54  ? 252 MET A CG  1 
ATOM   1900 S SD  . MET A 1 252 ? 111.925 128.002 143.296 1.00 35.54  ? 252 MET A SD  1 
ATOM   1901 C CE  . MET A 1 252 ? 111.101 127.511 144.797 1.00 35.54  ? 252 MET A CE  1 
ATOM   1902 N N   . VAL A 1 253 ? 115.728 126.414 146.948 1.00 35.15  ? 253 VAL A N   1 
ATOM   1903 C CA  . VAL A 1 253 ? 116.177 125.219 147.655 1.00 35.15  ? 253 VAL A CA  1 
ATOM   1904 C C   . VAL A 1 253 ? 114.965 124.349 147.939 1.00 35.15  ? 253 VAL A C   1 
ATOM   1905 O O   . VAL A 1 253 ? 114.044 124.774 148.637 1.00 35.15  ? 253 VAL A O   1 
ATOM   1906 C CB  . VAL A 1 253 ? 116.916 125.563 148.957 1.00 35.15  ? 253 VAL A CB  1 
ATOM   1907 C CG1 . VAL A 1 253 ? 117.102 124.330 149.794 1.00 35.15  ? 253 VAL A CG1 1 
ATOM   1908 C CG2 . VAL A 1 253 ? 118.264 126.122 148.651 1.00 35.15  ? 253 VAL A CG2 1 
ATOM   1909 N N   . TYR A 1 254 ? 114.950 123.129 147.411 1.00 36.36  ? 254 TYR A N   1 
ATOM   1910 C CA  . TYR A 1 254 ? 113.786 122.264 147.543 1.00 36.36  ? 254 TYR A CA  1 
ATOM   1911 C C   . TYR A 1 254 ? 113.989 121.282 148.683 1.00 36.36  ? 254 TYR A C   1 
ATOM   1912 O O   . TYR A 1 254 ? 115.104 120.842 148.956 1.00 36.36  ? 254 TYR A O   1 
ATOM   1913 C CB  . TYR A 1 254 ? 113.516 121.465 146.268 1.00 36.36  ? 254 TYR A CB  1 
ATOM   1914 C CG  . TYR A 1 254 ? 113.169 122.245 145.020 1.00 36.36  ? 254 TYR A CG  1 
ATOM   1915 C CD1 . TYR A 1 254 ? 112.897 123.593 145.055 1.00 36.36  ? 254 TYR A CD1 1 
ATOM   1916 C CD2 . TYR A 1 254 ? 113.100 121.608 143.804 1.00 36.36  ? 254 TYR A CD2 1 
ATOM   1917 C CE1 . TYR A 1 254 ? 112.590 124.283 143.916 1.00 36.36  ? 254 TYR A CE1 1 
ATOM   1918 C CE2 . TYR A 1 254 ? 112.791 122.288 142.661 1.00 36.36  ? 254 TYR A CE2 1 
ATOM   1919 C CZ  . TYR A 1 254 ? 112.535 123.625 142.722 1.00 36.36  ? 254 TYR A CZ  1 
ATOM   1920 O OH  . TYR A 1 254 ? 112.226 124.312 141.575 1.00 36.36  ? 254 TYR A OH  1 
ATOM   1921 N N   . ILE A 1 255 ? 112.894 120.928 149.342 1.00 37.56  ? 255 ILE A N   1 
ATOM   1922 C CA  . ILE A 1 255 ? 112.890 119.872 150.341 1.00 37.56  ? 255 ILE A CA  1 
ATOM   1923 C C   . ILE A 1 255 ? 111.886 118.830 149.884 1.00 37.56  ? 255 ILE A C   1 
ATOM   1924 O O   . ILE A 1 255 ? 110.711 119.145 149.684 1.00 37.56  ? 255 ILE A O   1 
ATOM   1925 C CB  . ILE A 1 255 ? 112.552 120.387 151.744 1.00 37.56  ? 255 ILE A CB  1 
ATOM   1926 C CG1 . ILE A 1 255 ? 113.674 121.270 152.262 1.00 37.56  ? 255 ILE A CG1 1 
ATOM   1927 C CG2 . ILE A 1 255 ? 112.345 119.240 152.697 1.00 37.56  ? 255 ILE A CG2 1 
ATOM   1928 C CD1 . ILE A 1 255 ? 113.325 121.981 153.518 1.00 37.56  ? 255 ILE A CD1 1 
ATOM   1929 N N   . TYR A 1 256 ? 112.351 117.605 149.687 1.00 40.90  ? 256 TYR A N   1 
ATOM   1930 C CA  . TYR A 1 256 ? 111.508 116.494 149.284 1.00 40.90  ? 256 TYR A CA  1 
ATOM   1931 C C   . TYR A 1 256 ? 111.346 115.520 150.434 1.00 40.90  ? 256 TYR A C   1 
ATOM   1932 O O   . TYR A 1 256 ? 112.168 115.476 151.349 1.00 40.90  ? 256 TYR A O   1 
ATOM   1933 C CB  . TYR A 1 256 ? 112.090 115.748 148.087 1.00 40.90  ? 256 TYR A CB  1 
ATOM   1934 C CG  . TYR A 1 256 ? 111.989 116.481 146.784 1.00 40.90  ? 256 TYR A CG  1 
ATOM   1935 C CD1 . TYR A 1 256 ? 110.822 116.461 146.056 1.00 40.90  ? 256 TYR A CD1 1 
ATOM   1936 C CD2 . TYR A 1 256 ? 113.069 117.179 146.279 1.00 40.90  ? 256 TYR A CD2 1 
ATOM   1937 C CE1 . TYR A 1 256 ? 110.726 117.119 144.868 1.00 40.90  ? 256 TYR A CE1 1 
ATOM   1938 C CE2 . TYR A 1 256 ? 112.984 117.843 145.092 1.00 40.90  ? 256 TYR A CE2 1 
ATOM   1939 C CZ  . TYR A 1 256 ? 111.810 117.810 144.389 1.00 40.90  ? 256 TYR A CZ  1 
ATOM   1940 O OH  . TYR A 1 256 ? 111.721 118.474 143.192 1.00 40.90  ? 256 TYR A OH  1 
ATOM   1941 N N   . ASP A 1 257 ? 110.283 114.730 150.369 1.00 43.30  ? 257 ASP A N   1 
ATOM   1942 C CA  . ASP A 1 257 ? 110.070 113.689 151.357 1.00 43.30  ? 257 ASP A CA  1 
ATOM   1943 C C   . ASP A 1 257 ? 111.097 112.584 151.170 1.00 43.30  ? 257 ASP A C   1 
ATOM   1944 O O   . ASP A 1 257 ? 111.521 112.282 150.056 1.00 43.30  ? 257 ASP A O   1 
ATOM   1945 C CB  . ASP A 1 257 ? 108.663 113.122 151.227 1.00 43.30  ? 257 ASP A CB  1 
ATOM   1946 C CG  . ASP A 1 257 ? 108.251 112.306 152.420 1.00 43.30  ? 257 ASP A CG  1 
ATOM   1947 O OD1 . ASP A 1 257 ? 109.026 112.210 153.385 1.00 43.30  ? 257 ASP A OD1 1 
ATOM   1948 O OD2 . ASP A 1 257 ? 107.141 111.747 152.395 1.00 43.30  ? 257 ASP A OD2 1 
ATOM   1949 N N   . GLY A 1 258 ? 111.509 111.981 152.283 1.00 43.14  ? 258 GLY A N   1 
ATOM   1950 C CA  . GLY A 1 258 ? 112.487 110.915 152.207 1.00 43.14  ? 258 GLY A CA  1 
ATOM   1951 C C   . GLY A 1 258 ? 111.886 109.571 151.883 1.00 43.14  ? 258 GLY A C   1 
ATOM   1952 O O   . GLY A 1 258 ? 112.597 108.664 151.449 1.00 43.14  ? 258 GLY A O   1 
ATOM   1953 N N   . LYS A 1 259 ? 110.584 109.422 152.075 1.00 45.10  ? 259 LYS A N   1 
ATOM   1954 C CA  . LYS A 1 259 ? 109.933 108.136 151.921 1.00 45.10  ? 259 LYS A CA  1 
ATOM   1955 C C   . LYS A 1 259 ? 109.344 107.922 150.542 1.00 45.10  ? 259 LYS A C   1 
ATOM   1956 O O   . LYS A 1 259 ? 109.310 106.782 150.076 1.00 45.10  ? 259 LYS A O   1 
ATOM   1957 C CB  . LYS A 1 259 ? 108.828 107.971 152.962 1.00 45.10  ? 259 LYS A CB  1 
ATOM   1958 N N   . ASN A 1 260 ? 108.858 108.969 149.875 1.00 47.75  ? 260 ASN A N   1 
ATOM   1959 C CA  . ASN A 1 260 ? 108.400 108.779 148.506 1.00 47.75  ? 260 ASN A CA  1 
ATOM   1960 C C   . ASN A 1 260 ? 108.712 109.926 147.549 1.00 47.75  ? 260 ASN A C   1 
ATOM   1961 O O   . ASN A 1 260 ? 108.115 109.957 146.464 1.00 47.75  ? 260 ASN A O   1 
ATOM   1962 C CB  . ASN A 1 260 ? 106.901 108.483 148.478 1.00 47.75  ? 260 ASN A CB  1 
ATOM   1963 C CG  . ASN A 1 260 ? 106.064 109.574 149.091 1.00 47.75  ? 260 ASN A CG  1 
ATOM   1964 O OD1 . ASN A 1 260 ? 106.569 110.564 149.606 1.00 47.75  ? 260 ASN A OD1 1 
ATOM   1965 N ND2 . ASN A 1 260 ? 104.757 109.399 149.018 1.00 47.75  ? 260 ASN A ND2 1 
ATOM   1966 N N   . MET A 1 261 ? 109.613 110.850 147.911 1.00 43.79  ? 261 MET A N   1 
ATOM   1967 C CA  . MET A 1 261 ? 110.097 111.944 147.055 1.00 43.79  ? 261 MET A CA  1 
ATOM   1968 C C   . MET A 1 261 ? 108.937 112.831 146.588 1.00 43.79  ? 261 MET A C   1 
ATOM   1969 O O   . MET A 1 261 ? 108.621 112.929 145.402 1.00 43.79  ? 261 MET A O   1 
ATOM   1970 C CB  . MET A 1 261 ? 110.912 111.390 145.871 1.00 43.79  ? 261 MET A CB  1 
ATOM   1971 C CG  . MET A 1 261 ? 111.741 112.379 145.037 1.00 43.79  ? 261 MET A CG  1 
ATOM   1972 S SD  . MET A 1 261 ? 113.222 113.048 145.792 1.00 43.79  ? 261 MET A SD  1 
ATOM   1973 C CE  . MET A 1 261 ? 114.322 111.662 145.630 1.00 43.79  ? 261 MET A CE  1 
ATOM   1974 N N   . SER A 1 262 ? 108.265 113.441 147.559 1.00 43.96  ? 262 SER A N   1 
ATOM   1975 C CA  . SER A 1 262 ? 107.214 114.417 147.308 1.00 43.96  ? 262 SER A CA  1 
ATOM   1976 C C   . SER A 1 262 ? 107.587 115.733 147.967 1.00 43.96  ? 262 SER A C   1 
ATOM   1977 O O   . SER A 1 262 ? 108.273 115.754 148.989 1.00 43.96  ? 262 SER A O   1 
ATOM   1978 C CB  . SER A 1 262 ? 105.864 113.943 147.835 1.00 43.96  ? 262 SER A CB  1 
ATOM   1979 O OG  . SER A 1 262 ? 105.408 112.820 147.112 1.00 43.96  ? 262 SER A OG  1 
ATOM   1980 N N   . SER A 1 263 ? 107.132 116.829 147.377 1.00 40.68  ? 263 SER A N   1 
ATOM   1981 C CA  . SER A 1 263 ? 107.633 118.140 147.757 1.00 40.68  ? 263 SER A CA  1 
ATOM   1982 C C   . SER A 1 263 ? 107.050 118.574 149.090 1.00 40.68  ? 263 SER A C   1 
ATOM   1983 O O   . SER A 1 263 ? 105.832 118.692 149.237 1.00 40.68  ? 263 SER A O   1 
ATOM   1984 C CB  . SER A 1 263 ? 107.307 119.162 146.677 1.00 40.68  ? 263 SER A CB  1 
ATOM   1985 O OG  . SER A 1 263 ? 107.823 120.431 147.027 1.00 40.68  ? 263 SER A OG  1 
ATOM   1986 N N   . LEU A 1 264 ? 107.926 118.818 150.060 1.00 39.44  ? 264 LEU A N   1 
ATOM   1987 C CA  . LEU A 1 264 ? 107.520 119.276 151.380 1.00 39.44  ? 264 LEU A CA  1 
ATOM   1988 C C   . LEU A 1 264 ? 107.552 120.795 151.481 1.00 39.44  ? 264 LEU A C   1 
ATOM   1989 O O   . LEU A 1 264 ? 106.536 121.425 151.779 1.00 39.44  ? 264 LEU A O   1 
ATOM   1990 C CB  . LEU A 1 264 ? 108.426 118.670 152.448 1.00 39.44  ? 264 LEU A CB  1 
ATOM   1991 C CG  . LEU A 1 264 ? 108.383 117.163 152.637 1.00 39.44  ? 264 LEU A CG  1 
ATOM   1992 C CD1 . LEU A 1 264 ? 109.405 116.759 153.678 1.00 39.44  ? 264 LEU A CD1 1 
ATOM   1993 C CD2 . LEU A 1 264 ? 106.997 116.730 153.041 1.00 39.44  ? 264 LEU A CD2 1 
ATOM   1994 N N   . TYR A 1 265 ? 108.713 121.395 151.248 1.00 37.00  ? 265 TYR A N   1 
ATOM   1995 C CA  . TYR A 1 265 ? 108.851 122.829 151.413 1.00 37.00  ? 265 TYR A CA  1 
ATOM   1996 C C   . TYR A 1 265 ? 109.815 123.367 150.375 1.00 37.00  ? 265 TYR A C   1 
ATOM   1997 O O   . TYR A 1 265 ? 110.575 122.621 149.761 1.00 37.00  ? 265 TYR A O   1 
ATOM   1998 C CB  . TYR A 1 265 ? 109.336 123.184 152.818 1.00 37.00  ? 265 TYR A CB  1 
ATOM   1999 N N   . ASN A 1 266 ? 109.773 124.682 150.189 1.00 35.89  ? 266 ASN A N   1 
ATOM   2000 C CA  . ASN A 1 266 ? 110.596 125.385 149.220 1.00 35.89  ? 266 ASN A CA  1 
ATOM   2001 C C   . ASN A 1 266 ? 111.259 126.580 149.878 1.00 35.89  ? 266 ASN A C   1 
ATOM   2002 O O   . ASN A 1 266 ? 110.780 127.096 150.885 1.00 35.89  ? 266 ASN A O   1 
ATOM   2003 C CB  . ASN A 1 266 ? 109.771 125.876 148.027 1.00 35.89  ? 266 ASN A CB  1 
ATOM   2004 C CG  . ASN A 1 266 ? 109.476 124.793 147.031 1.00 35.89  ? 266 ASN A CG  1 
ATOM   2005 O OD1 . ASN A 1 266 ? 110.300 123.933 146.794 1.00 35.89  ? 266 ASN A OD1 1 
ATOM   2006 N ND2 . ASN A 1 266 ? 108.309 124.844 146.426 1.00 35.89  ? 266 ASN A ND2 1 
ATOM   2007 N N   . PHE A 1 267 ? 112.356 127.026 149.292 1.00 34.66  ? 267 PHE A N   1 
ATOM   2008 C CA  . PHE A 1 267 ? 112.980 128.288 149.649 1.00 34.66  ? 267 PHE A CA  1 
ATOM   2009 C C   . PHE A 1 267 ? 113.193 129.067 148.372 1.00 34.66  ? 267 PHE A C   1 
ATOM   2010 O O   . PHE A 1 267 ? 113.109 128.501 147.285 1.00 34.66  ? 267 PHE A O   1 
ATOM   2011 C CB  . PHE A 1 267 ? 114.306 128.100 150.344 1.00 34.66  ? 267 PHE A CB  1 
ATOM   2012 C CG  . PHE A 1 267 ? 114.195 127.462 151.684 1.00 34.66  ? 267 PHE A CG  1 
ATOM   2013 C CD1 . PHE A 1 267 ? 113.870 128.207 152.795 1.00 34.66  ? 267 PHE A CD1 1 
ATOM   2014 C CD2 . PHE A 1 267 ? 114.411 126.110 151.830 1.00 34.66  ? 267 PHE A CD2 1 
ATOM   2015 C CE1 . PHE A 1 267 ? 113.770 127.615 154.010 1.00 34.66  ? 267 PHE A CE1 1 
ATOM   2016 C CE2 . PHE A 1 267 ? 114.306 125.526 153.046 1.00 34.66  ? 267 PHE A CE2 1 
ATOM   2017 C CZ  . PHE A 1 267 ? 113.991 126.280 154.129 1.00 34.66  ? 267 PHE A CZ  1 
ATOM   2018 N N   . THR A 1 268 ? 113.450 130.362 148.493 1.00 33.69  ? 268 THR A N   1 
ATOM   2019 C CA  . THR A 1 268 ? 113.616 131.225 147.336 1.00 33.69  ? 268 THR A CA  1 
ATOM   2020 C C   . THR A 1 268 ? 114.573 132.344 147.700 1.00 33.69  ? 268 THR A C   1 
ATOM   2021 O O   . THR A 1 268 ? 114.447 132.951 148.762 1.00 33.69  ? 268 THR A O   1 
ATOM   2022 C CB  . THR A 1 268 ? 112.273 131.803 146.879 1.00 33.69  ? 268 THR A CB  1 
ATOM   2023 O OG1 . THR A 1 268 ? 111.368 130.741 146.575 1.00 33.69  ? 268 THR A OG1 1 
ATOM   2024 C CG2 . THR A 1 268 ? 112.432 132.640 145.635 1.00 33.69  ? 268 THR A CG2 1 
ATOM   2025 N N   . GLY A 1 269 ? 115.535 132.609 146.832 1.00 34.03  ? 269 GLY A N   1 
ATOM   2026 C CA  . GLY A 1 269 ? 116.429 133.713 147.056 1.00 34.03  ? 269 GLY A CA  1 
ATOM   2027 C C   . GLY A 1 269 ? 115.731 135.039 146.842 1.00 34.03  ? 269 GLY A C   1 
ATOM   2028 O O   . GLY A 1 269 ? 114.616 135.130 146.330 1.00 34.03  ? 269 GLY A O   1 
ATOM   2029 N N   . GLU A 1 270 ? 116.421 136.098 147.247 1.00 34.46  ? 270 GLU A N   1 
ATOM   2030 C CA  . GLU A 1 270 ? 115.879 137.443 147.117 1.00 34.46  ? 270 GLU A CA  1 
ATOM   2031 C C   . GLU A 1 270 ? 116.646 138.322 146.153 1.00 34.46  ? 270 GLU A C   1 
ATOM   2032 O O   . GLU A 1 270 ? 116.114 139.356 145.743 1.00 34.46  ? 270 GLU A O   1 
ATOM   2033 C CB  . GLU A 1 270 ? 115.837 138.132 148.481 1.00 34.46  ? 270 GLU A CB  1 
ATOM   2034 N N   . GLN A 1 271 ? 117.865 137.969 145.780 1.00 34.47  ? 271 GLN A N   1 
ATOM   2035 C CA  . GLN A 1 271 ? 118.637 138.686 144.781 1.00 34.47  ? 271 GLN A CA  1 
ATOM   2036 C C   . GLN A 1 271 ? 118.963 137.736 143.642 1.00 34.47  ? 271 GLN A C   1 
ATOM   2037 O O   . GLN A 1 271 ? 119.408 136.611 143.883 1.00 34.47  ? 271 GLN A O   1 
ATOM   2038 C CB  . GLN A 1 271 ? 119.906 139.262 145.396 1.00 34.47  ? 271 GLN A CB  1 
ATOM   2039 C CG  . GLN A 1 271 ? 120.850 139.833 144.409 1.00 34.47  ? 271 GLN A CG  1 
ATOM   2040 C CD  . GLN A 1 271 ? 121.991 140.526 145.064 1.00 34.47  ? 271 GLN A CD  1 
ATOM   2041 O OE1 . GLN A 1 271 ? 121.985 140.737 146.257 1.00 34.47  ? 271 GLN A OE1 1 
ATOM   2042 N NE2 . GLN A 1 271 ? 123.010 140.836 144.298 1.00 34.47  ? 271 GLN A NE2 1 
ATOM   2043 N N   . MET A 1 272 ? 118.705 138.171 142.413 1.00 34.43  ? 272 MET A N   1 
ATOM   2044 C CA  . MET A 1 272 ? 119.049 137.381 141.246 1.00 34.43  ? 272 MET A CA  1 
ATOM   2045 C C   . MET A 1 272 ? 120.551 137.257 141.108 1.00 34.43  ? 272 MET A C   1 
ATOM   2046 O O   . MET A 1 272 ? 121.297 138.152 141.503 1.00 34.43  ? 272 MET A O   1 
ATOM   2047 C CB  . MET A 1 272 ? 118.479 138.022 139.993 1.00 34.43  ? 272 MET A CB  1 
ATOM   2048 C CG  . MET A 1 272 ? 116.996 137.892 139.865 1.00 34.43  ? 272 MET A CG  1 
ATOM   2049 S SD  . MET A 1 272 ? 116.371 138.906 138.539 1.00 34.43  ? 272 MET A SD  1 
ATOM   2050 C CE  . MET A 1 272 ? 117.152 138.102 137.171 1.00 34.43  ? 272 MET A CE  1 
ATOM   2051 N N   . ALA A 1 273 ? 120.985 136.128 140.558 1.00 34.86  ? 273 ALA A N   1 
ATOM   2052 C CA  . ALA A 1 273 ? 122.362 135.765 140.264 1.00 34.86  ? 273 ALA A CA  1 
ATOM   2053 C C   . ALA A 1 273 ? 123.254 135.740 141.493 1.00 34.86  ? 273 ALA A C   1 
ATOM   2054 O O   . ALA A 1 273 ? 124.431 136.052 141.377 1.00 34.86  ? 273 ALA A O   1 
ATOM   2055 C CB  . ALA A 1 273 ? 122.991 136.682 139.214 1.00 34.86  ? 273 ALA A CB  1 
ATOM   2056 N N   . ALA A 1 274 ? 122.741 135.365 142.657 1.00 35.52  ? 274 ALA A N   1 
ATOM   2057 C CA  . ALA A 1 274 ? 123.548 135.273 143.866 1.00 35.52  ? 274 ALA A CA  1 
ATOM   2058 C C   . ALA A 1 274 ? 123.872 133.841 144.271 1.00 35.52  ? 274 ALA A C   1 
ATOM   2059 O O   . ALA A 1 274 ? 124.528 133.649 145.295 1.00 35.52  ? 274 ALA A O   1 
ATOM   2060 C CB  . ALA A 1 274 ? 122.842 135.977 145.022 1.00 35.52  ? 274 ALA A CB  1 
ATOM   2061 N N   . TYR A 1 275 ? 123.420 132.852 143.494 1.00 35.55  ? 275 TYR A N   1 
ATOM   2062 C CA  . TYR A 1 275 ? 123.573 131.417 143.770 1.00 35.55  ? 275 TYR A CA  1 
ATOM   2063 C C   . TYR A 1 275 ? 122.947 130.991 145.086 1.00 35.55  ? 275 TYR A C   1 
ATOM   2064 O O   . TYR A 1 275 ? 123.612 130.461 145.972 1.00 35.55  ? 275 TYR A O   1 
ATOM   2065 C CB  . TYR A 1 275 ? 125.033 130.971 143.686 1.00 35.55  ? 275 TYR A CB  1 
ATOM   2066 C CG  . TYR A 1 275 ? 125.365 130.627 142.278 1.00 35.55  ? 275 TYR A CG  1 
ATOM   2067 C CD1 . TYR A 1 275 ? 125.223 129.327 141.819 1.00 35.55  ? 275 TYR A CD1 1 
ATOM   2068 C CD2 . TYR A 1 275 ? 125.693 131.613 141.377 1.00 35.55  ? 275 TYR A CD2 1 
ATOM   2069 C CE1 . TYR A 1 275 ? 125.460 129.014 140.526 1.00 35.55  ? 275 TYR A CE1 1 
ATOM   2070 C CE2 . TYR A 1 275 ? 125.952 131.314 140.098 1.00 35.55  ? 275 TYR A CE2 1 
ATOM   2071 C CZ  . TYR A 1 275 ? 125.818 130.021 139.669 1.00 35.55  ? 275 TYR A CZ  1 
ATOM   2072 O OH  . TYR A 1 275 ? 126.083 129.764 138.367 1.00 35.55  ? 275 TYR A OH  1 
ATOM   2073 N N   . PHE A 1 276 ? 121.639 131.169 145.182 1.00 32.92  ? 276 PHE A N   1 
ATOM   2074 C CA  . PHE A 1 276 ? 120.883 130.646 146.307 1.00 32.92  ? 276 PHE A CA  1 
ATOM   2075 C C   . PHE A 1 276 ? 120.664 129.160 146.068 1.00 32.92  ? 276 PHE A C   1 
ATOM   2076 O O   . PHE A 1 276 ? 119.731 128.765 145.370 1.00 32.92  ? 276 PHE A O   1 
ATOM   2077 C CB  . PHE A 1 276 ? 119.563 131.386 146.449 1.00 32.92  ? 276 PHE A CB  1 
ATOM   2078 C CG  . PHE A 1 276 ? 118.856 131.109 147.721 1.00 32.92  ? 276 PHE A CG  1 
ATOM   2079 C CD1 . PHE A 1 276 ? 119.246 131.743 148.876 1.00 32.92  ? 276 PHE A CD1 1 
ATOM   2080 C CD2 . PHE A 1 276 ? 117.816 130.216 147.768 1.00 32.92  ? 276 PHE A CD2 1 
ATOM   2081 C CE1 . PHE A 1 276 ? 118.603 131.505 150.045 1.00 32.92  ? 276 PHE A CE1 1 
ATOM   2082 C CE2 . PHE A 1 276 ? 117.171 129.964 148.939 1.00 32.92  ? 276 PHE A CE2 1 
ATOM   2083 C CZ  . PHE A 1 276 ? 117.560 130.612 150.079 1.00 32.92  ? 276 PHE A CZ  1 
ATOM   2084 N N   . GLY A 1 277 ? 121.522 128.336 146.647 1.00 32.09  ? 277 GLY A N   1 
ATOM   2085 C CA  . GLY A 1 277 ? 121.523 126.915 146.393 1.00 32.09  ? 277 GLY A CA  1 
ATOM   2086 C C   . GLY A 1 277 ? 122.892 126.356 146.130 1.00 32.09  ? 277 GLY A C   1 
ATOM   2087 O O   . GLY A 1 277 ? 123.000 125.185 145.751 1.00 32.09  ? 277 GLY A O   1 
ATOM   2088 N N   . PHE A 1 278 ? 123.945 127.147 146.302 1.00 33.02  ? 278 PHE A N   1 
ATOM   2089 C CA  . PHE A 1 278 ? 125.297 126.662 146.076 1.00 33.02  ? 278 PHE A CA  1 
ATOM   2090 C C   . PHE A 1 278 ? 125.713 125.694 147.170 1.00 33.02  ? 278 PHE A C   1 
ATOM   2091 O O   . PHE A 1 278 ? 126.452 124.739 146.913 1.00 33.02  ? 278 PHE A O   1 
ATOM   2092 C CB  . PHE A 1 278 ? 126.256 127.842 146.007 1.00 33.02  ? 278 PHE A CB  1 
ATOM   2093 C CG  . PHE A 1 278 ? 127.659 127.473 145.664 1.00 33.02  ? 278 PHE A CG  1 
ATOM   2094 C CD1 . PHE A 1 278 ? 128.020 127.240 144.369 1.00 33.02  ? 278 PHE A CD1 1 
ATOM   2095 C CD2 . PHE A 1 278 ? 128.624 127.382 146.639 1.00 33.02  ? 278 PHE A CD2 1 
ATOM   2096 C CE1 . PHE A 1 278 ? 129.308 126.897 144.048 1.00 33.02  ? 278 PHE A CE1 1 
ATOM   2097 C CE2 . PHE A 1 278 ? 129.911 127.047 146.324 1.00 33.02  ? 278 PHE A CE2 1 
ATOM   2098 C CZ  . PHE A 1 278 ? 130.254 126.808 145.031 1.00 33.02  ? 278 PHE A CZ  1 
ATOM   2099 N N   . SER A 1 279 ? 125.249 125.926 148.396 1.00 33.48  ? 279 SER A N   1 
ATOM   2100 C CA  . SER A 1 279 ? 125.510 125.056 149.529 1.00 33.48  ? 279 SER A CA  1 
ATOM   2101 C C   . SER A 1 279 ? 124.255 124.946 150.368 1.00 33.48  ? 279 SER A C   1 
ATOM   2102 O O   . SER A 1 279 ? 123.596 125.950 150.642 1.00 33.48  ? 279 SER A O   1 
ATOM   2103 C CB  . SER A 1 279 ? 126.626 125.588 150.380 1.00 33.48  ? 279 SER A CB  1 
ATOM   2104 O OG  . SER A 1 279 ? 127.803 125.667 149.621 1.00 33.48  ? 279 SER A OG  1 
ATOM   2105 N N   . VAL A 1 280 ? 123.911 123.723 150.755 1.00 33.89  ? 280 VAL A N   1 
ATOM   2106 C CA  . VAL A 1 280 ? 122.876 123.478 151.746 1.00 33.89  ? 280 VAL A CA  1 
ATOM   2107 C C   . VAL A 1 280 ? 123.461 122.576 152.820 1.00 33.89  ? 280 VAL A C   1 
ATOM   2108 O O   . VAL A 1 280 ? 124.270 121.690 152.522 1.00 33.89  ? 280 VAL A O   1 
ATOM   2109 C CB  . VAL A 1 280 ? 121.609 122.865 151.134 1.00 33.89  ? 280 VAL A CB  1 
ATOM   2110 C CG1 . VAL A 1 280 ? 120.886 123.894 150.330 1.00 33.89  ? 280 VAL A CG1 1 
ATOM   2111 C CG2 . VAL A 1 280 ? 121.964 121.744 150.241 1.00 33.89  ? 280 VAL A CG2 1 
ATOM   2112 N N   . ALA A 1 281 ? 123.094 122.836 154.072 1.00 36.42  ? 281 ALA A N   1 
ATOM   2113 C CA  . ALA A 1 281 ? 123.429 121.991 155.201 1.00 36.42  ? 281 ALA A CA  1 
ATOM   2114 C C   . ALA A 1 281 ? 122.188 121.801 156.049 1.00 36.42  ? 281 ALA A C   1 
ATOM   2115 O O   . ALA A 1 281 ? 121.168 122.455 155.842 1.00 36.42  ? 281 ALA A O   1 
ATOM   2116 C CB  . ALA A 1 281 ? 124.544 122.587 156.043 1.00 36.42  ? 281 ALA A CB  1 
ATOM   2117 N N   . ALA A 1 282 ? 122.275 120.880 157.001 1.00 40.11  ? 282 ALA A N   1 
ATOM   2118 C CA  . ALA A 1 282 ? 121.177 120.626 157.924 1.00 40.11  ? 282 ALA A CA  1 
ATOM   2119 C C   . ALA A 1 282 ? 121.739 120.105 159.235 1.00 40.11  ? 282 ALA A C   1 
ATOM   2120 O O   . ALA A 1 282 ? 122.229 118.976 159.294 1.00 40.11  ? 282 ALA A O   1 
ATOM   2121 C CB  . ALA A 1 282 ? 120.177 119.634 157.331 1.00 40.11  ? 282 ALA A CB  1 
ATOM   2122 N N   . THR A 1 283 ? 121.672 120.926 160.278 1.00 41.17  ? 283 THR A N   1 
ATOM   2123 C CA  . THR A 1 283 ? 121.994 120.476 161.621 1.00 41.17  ? 283 THR A CA  1 
ATOM   2124 C C   . THR A 1 283 ? 121.079 121.197 162.590 1.00 41.17  ? 283 THR A C   1 
ATOM   2125 O O   . THR A 1 283 ? 120.410 122.159 162.224 1.00 41.17  ? 283 THR A O   1 
ATOM   2126 C CB  . THR A 1 283 ? 123.462 120.717 161.983 1.00 41.17  ? 283 THR A CB  1 
ATOM   2127 O OG1 . THR A 1 283 ? 123.780 119.990 163.171 1.00 41.17  ? 283 THR A OG1 1 
ATOM   2128 C CG2 . THR A 1 283 ? 123.720 122.158 162.256 1.00 41.17  ? 283 THR A CG2 1 
ATOM   2129 N N   . ASP A 1 284 ? 121.041 120.707 163.822 1.00 43.91  ? 284 ASP A N   1 
ATOM   2130 C CA  . ASP A 1 284 ? 120.194 121.262 164.873 1.00 43.91  ? 284 ASP A CA  1 
ATOM   2131 C C   . ASP A 1 284 ? 120.992 122.308 165.629 1.00 43.91  ? 284 ASP A C   1 
ATOM   2132 O O   . ASP A 1 284 ? 121.565 122.019 166.675 1.00 43.91  ? 284 ASP A O   1 
ATOM   2133 C CB  . ASP A 1 284 ? 119.743 120.153 165.809 1.00 43.91  ? 284 ASP A CB  1 
ATOM   2134 C CG  . ASP A 1 284 ? 118.671 120.594 166.770 1.00 43.91  ? 284 ASP A CG  1 
ATOM   2135 O OD1 . ASP A 1 284 ? 118.199 121.744 166.675 1.00 43.91  ? 284 ASP A OD1 1 
ATOM   2136 O OD2 . ASP A 1 284 ? 118.312 119.785 167.644 1.00 43.91  ? 284 ASP A OD2 1 
ATOM   2137 N N   . ILE A 1 285 ? 121.004 123.541 165.125 1.00 43.80  ? 285 ILE A N   1 
ATOM   2138 C CA  . ILE A 1 285 ? 121.891 124.565 165.666 1.00 43.80  ? 285 ILE A CA  1 
ATOM   2139 C C   . ILE A 1 285 ? 121.424 125.107 167.014 1.00 43.80  ? 285 ILE A C   1 
ATOM   2140 O O   . ILE A 1 285 ? 122.235 125.682 167.754 1.00 43.80  ? 285 ILE A O   1 
ATOM   2141 C CB  . ILE A 1 285 ? 122.050 125.686 164.619 1.00 43.80  ? 285 ILE A CB  1 
ATOM   2142 C CG1 . ILE A 1 285 ? 123.330 126.478 164.833 1.00 43.80  ? 285 ILE A CG1 1 
ATOM   2143 C CG2 . ILE A 1 285 ? 120.891 126.640 164.642 1.00 43.80  ? 285 ILE A CG2 1 
ATOM   2144 C CD1 . ILE A 1 285 ? 124.543 125.712 164.485 1.00 43.80  ? 285 ILE A CD1 1 
ATOM   2145 N N   . ASN A 1 286 ? 120.157 124.908 167.387 1.00 44.58  ? 286 ASN A N   1 
ATOM   2146 C CA  . ASN A 1 286 ? 119.663 125.408 168.662 1.00 44.58  ? 286 ASN A CA  1 
ATOM   2147 C C   . ASN A 1 286 ? 119.259 124.304 169.625 1.00 44.58  ? 286 ASN A C   1 
ATOM   2148 O O   . ASN A 1 286 ? 118.959 124.593 170.785 1.00 44.58  ? 286 ASN A O   1 
ATOM   2149 C CB  . ASN A 1 286 ? 118.483 126.366 168.470 1.00 44.58  ? 286 ASN A CB  1 
ATOM   2150 C CG  . ASN A 1 286 ? 117.334 125.754 167.711 1.00 44.58  ? 286 ASN A CG  1 
ATOM   2151 O OD1 . ASN A 1 286 ? 117.413 124.639 167.214 1.00 44.58  ? 286 ASN A OD1 1 
ATOM   2152 N ND2 . ASN A 1 286 ? 116.234 126.475 167.656 1.00 44.58  ? 286 ASN A ND2 1 
ATOM   2153 N N   . GLY A 1 287 ? 119.238 123.055 169.187 1.00 43.73  ? 287 GLY A N   1 
ATOM   2154 C CA  . GLY A 1 287 ? 118.880 121.990 170.089 1.00 43.73  ? 287 GLY A CA  1 
ATOM   2155 C C   . GLY A 1 287 ? 117.405 121.834 170.330 1.00 43.73  ? 287 GLY A C   1 
ATOM   2156 O O   . GLY A 1 287 ? 117.012 121.390 171.408 1.00 43.73  ? 287 GLY A O   1 
ATOM   2157 N N   . ASP A 1 288 ? 116.568 122.181 169.364 1.00 45.72  ? 288 ASP A N   1 
ATOM   2158 C CA  . ASP A 1 288 ? 115.144 121.971 169.549 1.00 45.72  ? 288 ASP A CA  1 
ATOM   2159 C C   . ASP A 1 288 ? 114.671 120.629 169.021 1.00 45.72  ? 288 ASP A C   1 
ATOM   2160 O O   . ASP A 1 288 ? 113.457 120.429 168.927 1.00 45.72  ? 288 ASP A O   1 
ATOM   2161 C CB  . ASP A 1 288 ? 114.336 123.109 168.904 1.00 45.72  ? 288 ASP A CB  1 
ATOM   2162 C CG  . ASP A 1 288 ? 114.583 123.273 167.394 1.00 45.72  ? 288 ASP A CG  1 
ATOM   2163 O OD1 . ASP A 1 288 ? 115.442 122.594 166.788 1.00 45.72  ? 288 ASP A OD1 1 
ATOM   2164 O OD2 . ASP A 1 288 ? 113.888 124.121 166.797 1.00 45.72  ? 288 ASP A OD2 1 
ATOM   2165 N N   . ASP A 1 289 ? 115.599 119.725 168.687 1.00 44.38  ? 289 ASP A N   1 
ATOM   2166 C CA  . ASP A 1 289 ? 115.353 118.435 168.038 1.00 44.38  ? 289 ASP A CA  1 
ATOM   2167 C C   . ASP A 1 289 ? 114.643 118.582 166.701 1.00 44.38  ? 289 ASP A C   1 
ATOM   2168 O O   . ASP A 1 289 ? 113.903 117.685 166.287 1.00 44.38  ? 289 ASP A O   1 
ATOM   2169 C CB  . ASP A 1 289 ? 114.584 117.465 168.945 1.00 44.38  ? 289 ASP A CB  1 
ATOM   2170 N N   . TYR A 1 290 ? 114.869 119.699 166.011 1.00 43.25  ? 290 TYR A N   1 
ATOM   2171 C CA  . TYR A 1 290 ? 114.408 119.917 164.650 1.00 43.25  ? 290 TYR A CA  1 
ATOM   2172 C C   . TYR A 1 290 ? 115.574 120.438 163.827 1.00 43.25  ? 290 TYR A C   1 
ATOM   2173 O O   . TYR A 1 290 ? 116.227 121.408 164.225 1.00 43.25  ? 290 TYR A O   1 
ATOM   2174 C CB  . TYR A 1 290 ? 113.261 120.909 164.597 1.00 43.25  ? 290 TYR A CB  1 
ATOM   2175 C CG  . TYR A 1 290 ? 112.000 120.426 165.232 1.00 43.25  ? 290 TYR A CG  1 
ATOM   2176 C CD1 . TYR A 1 290 ? 111.206 119.494 164.606 1.00 43.25  ? 290 TYR A CD1 1 
ATOM   2177 C CD2 . TYR A 1 290 ? 111.581 120.936 166.436 1.00 43.25  ? 290 TYR A CD2 1 
ATOM   2178 C CE1 . TYR A 1 290 ? 110.050 119.061 165.178 1.00 43.25  ? 290 TYR A CE1 1 
ATOM   2179 C CE2 . TYR A 1 290 ? 110.425 120.510 167.018 1.00 43.25  ? 290 TYR A CE2 1 
ATOM   2180 C CZ  . TYR A 1 290 ? 109.664 119.574 166.385 1.00 43.25  ? 290 TYR A CZ  1 
ATOM   2181 O OH  . TYR A 1 290 ? 108.500 119.147 166.971 1.00 43.25  ? 290 TYR A OH  1 
ATOM   2182 N N   . ALA A 1 291 ? 115.819 119.799 162.682 1.00 41.98  ? 291 ALA A N   1 
ATOM   2183 C CA  . ALA A 1 291 ? 116.974 120.123 161.855 1.00 41.98  ? 291 ALA A CA  1 
ATOM   2184 C C   . ALA A 1 291 ? 116.772 121.456 161.154 1.00 41.98  ? 291 ALA A C   1 
ATOM   2185 O O   . ALA A 1 291 ? 115.675 121.757 160.685 1.00 41.98  ? 291 ALA A O   1 
ATOM   2186 C CB  . ALA A 1 291 ? 117.210 119.019 160.828 1.00 41.98  ? 291 ALA A CB  1 
ATOM   2187 N N   . ASP A 1 292 ? 117.833 122.242 161.059 1.00 41.12  ? 292 ASP A N   1 
ATOM   2188 C CA  . ASP A 1 292 ? 117.736 123.617 160.599 1.00 41.12  ? 292 ASP A CA  1 
ATOM   2189 C C   . ASP A 1 292 ? 118.465 123.768 159.270 1.00 41.12  ? 292 ASP A C   1 
ATOM   2190 O O   . ASP A 1 292 ? 119.548 123.214 159.088 1.00 41.12  ? 292 ASP A O   1 
ATOM   2191 C CB  . ASP A 1 292 ? 118.325 124.560 161.649 1.00 41.12  ? 292 ASP A CB  1 
ATOM   2192 C CG  . ASP A 1 292 ? 117.617 124.456 162.989 1.00 41.12  ? 292 ASP A CG  1 
ATOM   2193 O OD1 . ASP A 1 292 ? 116.421 124.114 163.014 1.00 41.12  ? 292 ASP A OD1 1 
ATOM   2194 O OD2 . ASP A 1 292 ? 118.258 124.700 164.025 1.00 41.12  ? 292 ASP A OD2 1 
ATOM   2195 N N   . VAL A 1 293 ? 117.870 124.525 158.344 1.00 37.44  ? 293 VAL A N   1 
ATOM   2196 C CA  . VAL A 1 293 ? 118.350 124.634 156.966 1.00 37.44  ? 293 VAL A CA  1 
ATOM   2197 C C   . VAL A 1 293 ? 119.338 125.791 156.873 1.00 37.44  ? 293 VAL A C   1 
ATOM   2198 O O   . VAL A 1 293 ? 119.104 126.862 157.439 1.00 37.44  ? 293 VAL A O   1 
ATOM   2199 C CB  . VAL A 1 293 ? 117.178 124.825 155.993 1.00 37.44  ? 293 VAL A CB  1 
ATOM   2200 C CG1 . VAL A 1 293 ? 117.642 124.790 154.572 1.00 37.44  ? 293 VAL A CG1 1 
ATOM   2201 C CG2 . VAL A 1 293 ? 116.170 123.766 156.200 1.00 37.44  ? 293 VAL A CG2 1 
ATOM   2202 N N   . PHE A 1 294 ? 120.441 125.575 156.162 1.00 36.84  ? 294 PHE A N   1 
ATOM   2203 C CA  . PHE A 1 294 ? 121.556 126.508 156.103 1.00 36.84  ? 294 PHE A CA  1 
ATOM   2204 C C   . PHE A 1 294 ? 121.955 126.673 154.650 1.00 36.84  ? 294 PHE A C   1 
ATOM   2205 O O   . PHE A 1 294 ? 122.653 125.817 154.102 1.00 36.84  ? 294 PHE A O   1 
ATOM   2206 C CB  . PHE A 1 294 ? 122.711 125.953 156.917 1.00 36.84  ? 294 PHE A CB  1 
ATOM   2207 C CG  . PHE A 1 294 ? 122.439 125.915 158.369 1.00 36.84  ? 294 PHE A CG  1 
ATOM   2208 C CD1 . PHE A 1 294 ? 121.997 127.025 159.031 1.00 36.84  ? 294 PHE A CD1 1 
ATOM   2209 C CD2 . PHE A 1 294 ? 122.437 124.711 159.034 1.00 36.84  ? 294 PHE A CD2 1 
ATOM   2210 C CE1 . PHE A 1 294 ? 121.709 126.968 160.363 1.00 36.84  ? 294 PHE A CE1 1 
ATOM   2211 C CE2 . PHE A 1 294 ? 122.093 124.651 160.352 1.00 36.84  ? 294 PHE A CE2 1 
ATOM   2212 C CZ  . PHE A 1 294 ? 121.747 125.777 161.017 1.00 36.84  ? 294 PHE A CZ  1 
ATOM   2213 N N   . ILE A 1 295 ? 121.536 127.772 154.030 1.00 33.74  ? 295 ILE A N   1 
ATOM   2214 C CA  . ILE A 1 295 ? 121.627 127.947 152.586 1.00 33.74  ? 295 ILE A CA  1 
ATOM   2215 C C   . ILE A 1 295 ? 122.626 129.043 152.278 1.00 33.74  ? 295 ILE A C   1 
ATOM   2216 O O   . ILE A 1 295 ? 122.384 130.208 152.594 1.00 33.74  ? 295 ILE A O   1 
ATOM   2217 C CB  . ILE A 1 295 ? 120.276 128.306 151.983 1.00 33.74  ? 295 ILE A CB  1 
ATOM   2218 C CG1 . ILE A 1 295 ? 119.274 127.232 152.329 1.00 33.74  ? 295 ILE A CG1 1 
ATOM   2219 C CG2 . ILE A 1 295 ? 120.434 128.429 150.520 1.00 33.74  ? 295 ILE A CG2 1 
ATOM   2220 C CD1 . ILE A 1 295 ? 117.873 127.637 152.085 1.00 33.74  ? 295 ILE A CD1 1 
ATOM   2221 N N   . GLY A 1 296 ? 123.713 128.688 151.613 1.00 34.46  ? 296 GLY A N   1 
ATOM   2222 C CA  . GLY A 1 296 ? 124.709 129.659 151.229 1.00 34.46  ? 296 GLY A CA  1 
ATOM   2223 C C   . GLY A 1 296 ? 124.447 130.265 149.862 1.00 34.46  ? 296 GLY A C   1 
ATOM   2224 O O   . GLY A 1 296 ? 123.932 129.613 148.958 1.00 34.46  ? 296 GLY A O   1 
ATOM   2225 N N   . ALA A 1 297 ? 124.806 131.542 149.734 1.00 34.72  ? 297 ALA A N   1 
ATOM   2226 C CA  . ALA A 1 297 ? 124.705 132.270 148.469 1.00 34.72  ? 297 ALA A CA  1 
ATOM   2227 C C   . ALA A 1 297 ? 125.949 133.119 148.330 1.00 34.72  ? 297 ALA A C   1 
ATOM   2228 O O   . ALA A 1 297 ? 125.977 134.274 148.766 1.00 34.72  ? 297 ALA A O   1 
ATOM   2229 C CB  . ALA A 1 297 ? 123.452 133.137 148.409 1.00 34.72  ? 297 ALA A CB  1 
ATOM   2230 N N   . PRO A 1 298 ? 127.004 132.582 147.712 1.00 34.65  ? 298 PRO A N   1 
ATOM   2231 C CA  . PRO A 1 298 ? 128.312 133.245 147.765 1.00 34.65  ? 298 PRO A CA  1 
ATOM   2232 C C   . PRO A 1 298 ? 128.404 134.505 146.946 1.00 34.65  ? 298 PRO A C   1 
ATOM   2233 O O   . PRO A 1 298 ? 129.315 135.304 147.178 1.00 34.65  ? 298 PRO A O   1 
ATOM   2234 C CB  . PRO A 1 298 ? 129.257 132.185 147.199 1.00 34.65  ? 298 PRO A CB  1 
ATOM   2235 C CG  . PRO A 1 298 ? 128.530 130.937 147.282 1.00 34.65  ? 298 PRO A CG  1 
ATOM   2236 C CD  . PRO A 1 298 ? 127.110 131.268 147.075 1.00 34.65  ? 298 PRO A CD  1 
ATOM   2237 N N   . LEU A 1 299 ? 127.514 134.700 145.977 1.00 37.35  ? 299 LEU A N   1 
ATOM   2238 C CA  . LEU A 1 299 ? 127.591 135.835 145.072 1.00 37.35  ? 299 LEU A CA  1 
ATOM   2239 C C   . LEU A 1 299 ? 126.555 136.895 145.408 1.00 37.35  ? 299 LEU A C   1 
ATOM   2240 O O   . LEU A 1 299 ? 126.020 137.546 144.508 1.00 37.35  ? 299 LEU A O   1 
ATOM   2241 C CB  . LEU A 1 299 ? 127.437 135.376 143.625 1.00 37.35  ? 299 LEU A CB  1 
ATOM   2242 C CG  . LEU A 1 299 ? 128.354 134.264 143.102 1.00 37.35  ? 299 LEU A CG  1 
ATOM   2243 C CD1 . LEU A 1 299 ? 128.174 134.122 141.610 1.00 37.35  ? 299 LEU A CD1 1 
ATOM   2244 C CD2 . LEU A 1 299 ? 129.822 134.392 143.457 1.00 37.35  ? 299 LEU A CD2 1 
ATOM   2245 N N   . PHE A 1 300 ? 126.262 137.075 146.694 1.00 38.03  ? 300 PHE A N   1 
ATOM   2246 C CA  . PHE A 1 300 ? 125.287 138.058 147.142 1.00 38.03  ? 300 PHE A CA  1 
ATOM   2247 C C   . PHE A 1 300 ? 125.962 139.408 147.310 1.00 38.03  ? 300 PHE A C   1 
ATOM   2248 O O   . PHE A 1 300 ? 127.017 139.506 147.937 1.00 38.03  ? 300 PHE A O   1 
ATOM   2249 C CB  . PHE A 1 300 ? 124.663 137.618 148.461 1.00 38.03  ? 300 PHE A CB  1 
ATOM   2250 C CG  . PHE A 1 300 ? 123.560 138.513 148.952 1.00 38.03  ? 300 PHE A CG  1 
ATOM   2251 C CD1 . PHE A 1 300 ? 122.287 138.399 148.447 1.00 38.03  ? 300 PHE A CD1 1 
ATOM   2252 C CD2 . PHE A 1 300 ? 123.799 139.461 149.926 1.00 38.03  ? 300 PHE A CD2 1 
ATOM   2253 C CE1 . PHE A 1 300 ? 121.279 139.208 148.906 1.00 38.03  ? 300 PHE A CE1 1 
ATOM   2254 C CE2 . PHE A 1 300 ? 122.795 140.274 150.371 1.00 38.03  ? 300 PHE A CE2 1 
ATOM   2255 C CZ  . PHE A 1 300 ? 121.540 140.148 149.857 1.00 38.03  ? 300 PHE A CZ  1 
ATOM   2256 N N   . MET A 1 301 ? 125.344 140.445 146.756 1.00 42.21  ? 301 MET A N   1 
ATOM   2257 C CA  . MET A 1 301 ? 125.818 141.818 146.863 1.00 42.21  ? 301 MET A CA  1 
ATOM   2258 C C   . MET A 1 301 ? 124.896 142.591 147.790 1.00 42.21  ? 301 MET A C   1 
ATOM   2259 O O   . MET A 1 301 ? 123.698 142.693 147.522 1.00 42.21  ? 301 MET A O   1 
ATOM   2260 C CB  . MET A 1 301 ? 125.838 142.502 145.492 1.00 42.21  ? 301 MET A CB  1 
ATOM   2261 C CG  . MET A 1 301 ? 126.838 141.960 144.499 1.00 42.21  ? 301 MET A CG  1 
ATOM   2262 S SD  . MET A 1 301 ? 126.863 142.863 142.957 1.00 42.21  ? 301 MET A SD  1 
ATOM   2263 C CE  . MET A 1 301 ? 125.403 142.201 142.199 1.00 42.21  ? 301 MET A CE  1 
ATOM   2264 N N   . ASP A 1 302 ? 125.440 143.139 148.867 1.00 49.10  ? 302 ASP A N   1 
ATOM   2265 C CA  . ASP A 1 302 ? 124.635 143.976 149.738 1.00 49.10  ? 302 ASP A CA  1 
ATOM   2266 C C   . ASP A 1 302 ? 124.975 145.444 149.531 1.00 49.10  ? 302 ASP A C   1 
ATOM   2267 O O   . ASP A 1 302 ? 126.058 145.785 149.054 1.00 49.10  ? 302 ASP A O   1 
ATOM   2268 C CB  . ASP A 1 302 ? 124.794 143.600 151.218 1.00 49.10  ? 302 ASP A CB  1 
ATOM   2269 C CG  . ASP A 1 302 ? 126.210 143.771 151.750 1.00 49.10  ? 302 ASP A CG  1 
ATOM   2270 O OD1 . ASP A 1 302 ? 127.166 143.976 150.982 1.00 49.10  ? 302 ASP A OD1 1 
ATOM   2271 O OD2 . ASP A 1 302 ? 126.364 143.723 152.986 1.00 49.10  ? 302 ASP A OD2 1 
ATOM   2272 N N   . ARG A 1 303 ? 124.030 146.310 149.886 1.00 55.26  ? 303 ARG A N   1 
ATOM   2273 C CA  . ARG A 1 303 ? 124.277 147.744 149.872 1.00 55.26  ? 303 ARG A CA  1 
ATOM   2274 C C   . ARG A 1 303 ? 125.267 148.090 150.971 1.00 55.26  ? 303 ARG A C   1 
ATOM   2275 O O   . ARG A 1 303 ? 125.091 147.680 152.122 1.00 55.26  ? 303 ARG A O   1 
ATOM   2276 C CB  . ARG A 1 303 ? 122.977 148.510 150.077 1.00 55.26  ? 303 ARG A CB  1 
ATOM   2277 C CG  . ARG A 1 303 ? 121.958 148.312 148.992 1.00 55.26  ? 303 ARG A CG  1 
ATOM   2278 C CD  . ARG A 1 303 ? 122.348 149.028 147.730 1.00 55.26  ? 303 ARG A CD  1 
ATOM   2279 N NE  . ARG A 1 303 ? 121.343 148.840 146.694 1.00 55.26  ? 303 ARG A NE  1 
ATOM   2280 C CZ  . ARG A 1 303 ? 121.455 149.301 145.454 1.00 55.26  ? 303 ARG A CZ  1 
ATOM   2281 N NH1 . ARG A 1 303 ? 122.532 149.987 145.098 1.00 55.26  ? 303 ARG A NH1 1 
ATOM   2282 N NH2 . ARG A 1 303 ? 120.490 149.079 144.571 1.00 55.26  ? 303 ARG A NH2 1 
ATOM   2283 N N   . GLY A 1 304 ? 126.308 148.831 150.626 1.00 59.51  ? 304 GLY A N   1 
ATOM   2284 C CA  . GLY A 1 304 ? 127.190 149.370 151.637 1.00 59.51  ? 304 GLY A CA  1 
ATOM   2285 C C   . GLY A 1 304 ? 126.573 150.564 152.340 1.00 59.51  ? 304 GLY A C   1 
ATOM   2286 O O   . GLY A 1 304 ? 125.416 150.931 152.130 1.00 59.51  ? 304 GLY A O   1 
ATOM   2287 N N   . SER A 1 305 ? 127.371 151.192 153.205 1.00 66.77  ? 305 SER A N   1 
ATOM   2288 C CA  . SER A 1 305 ? 126.910 152.412 153.861 1.00 66.77  ? 305 SER A CA  1 
ATOM   2289 C C   . SER A 1 305 ? 126.850 153.582 152.886 1.00 66.77  ? 305 SER A C   1 
ATOM   2290 O O   . SER A 1 305 ? 126.088 154.532 153.102 1.00 66.77  ? 305 SER A O   1 
ATOM   2291 C CB  . SER A 1 305 ? 127.812 152.749 155.048 1.00 66.77  ? 305 SER A CB  1 
ATOM   2292 O OG  . SER A 1 305 ? 127.713 151.760 156.058 1.00 66.77  ? 305 SER A OG  1 
ATOM   2293 N N   . ASP A 1 306 ? 127.639 153.531 151.809 1.00 66.16  ? 306 ASP A N   1 
ATOM   2294 C CA  . ASP A 1 306 ? 127.572 154.542 150.762 1.00 66.16  ? 306 ASP A CA  1 
ATOM   2295 C C   . ASP A 1 306 ? 126.478 154.263 149.742 1.00 66.16  ? 306 ASP A C   1 
ATOM   2296 O O   . ASP A 1 306 ? 126.085 155.177 149.011 1.00 66.16  ? 306 ASP A O   1 
ATOM   2297 C CB  . ASP A 1 306 ? 128.917 154.644 150.043 1.00 66.16  ? 306 ASP A CB  1 
ATOM   2298 C CG  . ASP A 1 306 ? 130.003 155.221 150.922 1.00 66.16  ? 306 ASP A CG  1 
ATOM   2299 O OD1 . ASP A 1 306 ? 129.675 156.009 151.833 1.00 66.16  ? 306 ASP A OD1 1 
ATOM   2300 O OD2 . ASP A 1 306 ? 131.187 154.892 150.702 1.00 66.16  ? 306 ASP A OD2 1 
ATOM   2301 N N   . GLY A 1 307 ? 125.982 153.032 149.675 1.00 61.15  ? 307 GLY A N   1 
ATOM   2302 C CA  . GLY A 1 307 ? 125.042 152.629 148.654 1.00 61.15  ? 307 GLY A CA  1 
ATOM   2303 C C   . GLY A 1 307 ? 125.624 151.715 147.599 1.00 61.15  ? 307 GLY A C   1 
ATOM   2304 O O   . GLY A 1 307 ? 124.881 151.256 146.723 1.00 61.15  ? 307 GLY A O   1 
ATOM   2305 N N   . LYS A 1 308 ? 126.924 151.445 147.655 1.00 56.06  ? 308 LYS A N   1 
ATOM   2306 C CA  . LYS A 1 308 ? 127.555 150.552 146.699 1.00 56.06  ? 308 LYS A CA  1 
ATOM   2307 C C   . LYS A 1 308 ? 127.151 149.112 146.966 1.00 56.06  ? 308 LYS A C   1 
ATOM   2308 O O   . LYS A 1 308 ? 126.928 148.708 148.108 1.00 56.06  ? 308 LYS A O   1 
ATOM   2309 C CB  . LYS A 1 308 ? 129.074 150.673 146.773 1.00 56.06  ? 308 LYS A CB  1 
ATOM   2310 C CG  . LYS A 1 308 ? 129.616 151.974 146.256 1.00 56.06  ? 308 LYS A CG  1 
ATOM   2311 C CD  . LYS A 1 308 ? 131.100 152.085 146.500 1.00 56.06  ? 308 LYS A CD  1 
ATOM   2312 C CE  . LYS A 1 308 ? 131.868 151.135 145.606 1.00 56.06  ? 308 LYS A CE  1 
ATOM   2313 N NZ  . LYS A 1 308 ? 133.340 151.302 145.751 1.00 56.06  ? 308 LYS A NZ  1 
ATOM   2314 N N   . LEU A 1 309 ? 127.062 148.331 145.898 1.00 49.26  ? 309 LEU A N   1 
ATOM   2315 C CA  . LEU A 1 309 ? 126.797 146.906 146.007 1.00 49.26  ? 309 LEU A CA  1 
ATOM   2316 C C   . LEU A 1 309 ? 128.118 146.178 146.197 1.00 49.26  ? 309 LEU A C   1 
ATOM   2317 O O   . LEU A 1 309 ? 128.930 146.100 145.272 1.00 49.26  ? 309 LEU A O   1 
ATOM   2318 C CB  . LEU A 1 309 ? 126.057 146.406 144.777 1.00 49.26  ? 309 LEU A CB  1 
ATOM   2319 C CG  . LEU A 1 309 ? 124.613 146.861 144.744 1.00 49.26  ? 309 LEU A CG  1 
ATOM   2320 C CD1 . LEU A 1 309 ? 124.018 146.500 143.427 1.00 49.26  ? 309 LEU A CD1 1 
ATOM   2321 C CD2 . LEU A 1 309 ? 123.871 146.165 145.846 1.00 49.26  ? 309 LEU A CD2 1 
ATOM   2322 N N   . GLN A 1 310 ? 128.334 145.654 147.395 1.00 47.95  ? 310 GLN A N   1 
ATOM   2323 C CA  . GLN A 1 310 ? 129.544 144.924 147.740 1.00 47.95  ? 310 GLN A CA  1 
ATOM   2324 C C   . GLN A 1 310 ? 129.220 143.439 147.766 1.00 47.95  ? 310 GLN A C   1 
ATOM   2325 O O   . GLN A 1 310 ? 128.389 142.997 148.562 1.00 47.95  ? 310 GLN A O   1 
ATOM   2326 C CB  . GLN A 1 310 ? 130.079 145.381 149.093 1.00 47.95  ? 310 GLN A CB  1 
ATOM   2327 C CG  . GLN A 1 310 ? 130.484 146.838 149.139 1.00 47.95  ? 310 GLN A CG  1 
ATOM   2328 C CD  . GLN A 1 310 ? 131.704 147.133 148.287 1.00 47.95  ? 310 GLN A CD  1 
ATOM   2329 O OE1 . GLN A 1 310 ? 132.640 146.334 148.226 1.00 47.95  ? 310 GLN A OE1 1 
ATOM   2330 N NE2 . GLN A 1 310 ? 131.703 148.287 147.627 1.00 47.95  ? 310 GLN A NE2 1 
ATOM   2331 N N   . GLU A 1 311 ? 129.879 142.673 146.909 1.00 43.18  ? 311 GLU A N   1 
ATOM   2332 C CA  . GLU A 1 311 ? 129.642 141.235 146.823 1.00 43.18  ? 311 GLU A CA  1 
ATOM   2333 C C   . GLU A 1 311 ? 130.339 140.549 147.988 1.00 43.18  ? 311 GLU A C   1 
ATOM   2334 O O   . GLU A 1 311 ? 131.530 140.243 147.919 1.00 43.18  ? 311 GLU A O   1 
ATOM   2335 C CB  . GLU A 1 311 ? 130.132 140.699 145.486 1.00 43.18  ? 311 GLU A CB  1 
ATOM   2336 C CG  . GLU A 1 311 ? 129.889 139.227 145.275 1.00 43.18  ? 311 GLU A CG  1 
ATOM   2337 C CD  . GLU A 1 311 ? 130.320 138.785 143.908 1.00 43.18  ? 311 GLU A CD  1 
ATOM   2338 O OE1 . GLU A 1 311 ? 130.700 139.639 143.096 1.00 43.18  ? 311 GLU A OE1 1 
ATOM   2339 O OE2 . GLU A 1 311 ? 130.306 137.573 143.651 1.00 43.18  ? 311 GLU A OE2 1 
ATOM   2340 N N   . VAL A 1 312 ? 129.590 140.290 149.062 1.00 39.61  ? 312 VAL A N   1 
ATOM   2341 C CA  . VAL A 1 312 ? 130.165 139.740 150.275 1.00 39.61  ? 312 VAL A CA  1 
ATOM   2342 C C   . VAL A 1 312 ? 129.776 138.287 150.512 1.00 39.61  ? 312 VAL A C   1 
ATOM   2343 O O   . VAL A 1 312 ? 130.574 137.540 151.082 1.00 39.61  ? 312 VAL A O   1 
ATOM   2344 C CB  . VAL A 1 312 ? 129.811 140.608 151.499 1.00 39.61  ? 312 VAL A CB  1 
ATOM   2345 C CG1 . VAL A 1 312 ? 130.475 141.947 151.388 1.00 39.61  ? 312 VAL A CG1 1 
ATOM   2346 C CG2 . VAL A 1 312 ? 128.324 140.791 151.620 1.00 39.61  ? 312 VAL A CG2 1 
ATOM   2347 N N   . GLY A 1 313 ? 128.610 137.852 150.064 1.00 36.36  ? 313 GLY A N   1 
ATOM   2348 C CA  . GLY A 1 313 ? 128.121 136.526 150.364 1.00 36.36  ? 313 GLY A CA  1 
ATOM   2349 C C   . GLY A 1 313 ? 127.062 136.552 151.446 1.00 36.36  ? 313 GLY A C   1 
ATOM   2350 O O   . GLY A 1 313 ? 126.944 137.497 152.220 1.00 36.36  ? 313 GLY A O   1 
ATOM   2351 N N   . GLN A 1 314 ? 126.278 135.484 151.507 1.00 35.11  ? 314 GLN A N   1 
ATOM   2352 C CA  . GLN A 1 314 ? 125.181 135.444 152.458 1.00 35.11  ? 314 GLN A CA  1 
ATOM   2353 C C   . GLN A 1 314 ? 124.833 133.998 152.761 1.00 35.11  ? 314 GLN A C   1 
ATOM   2354 O O   . GLN A 1 314 ? 124.924 133.144 151.881 1.00 35.11  ? 314 GLN A O   1 
ATOM   2355 C CB  . GLN A 1 314 ? 123.948 136.151 151.903 1.00 35.11  ? 314 GLN A CB  1 
ATOM   2356 C CG  . GLN A 1 314 ? 122.924 136.505 152.950 1.00 35.11  ? 314 GLN A CG  1 
ATOM   2357 C CD  . GLN A 1 314 ? 121.674 137.068 152.357 1.00 35.11  ? 314 GLN A CD  1 
ATOM   2358 O OE1 . GLN A 1 314 ? 121.402 136.884 151.178 1.00 35.11  ? 314 GLN A OE1 1 
ATOM   2359 N NE2 . GLN A 1 314 ? 120.951 137.835 153.138 1.00 35.11  ? 314 GLN A NE2 1 
ATOM   2360 N N   . VAL A 1 315 ? 124.430 133.733 154.002 1.00 34.34  ? 315 VAL A N   1 
ATOM   2361 C CA  . VAL A 1 315 ? 123.964 132.417 154.426 1.00 34.34  ? 315 VAL A CA  1 
ATOM   2362 C C   . VAL A 1 315 ? 122.574 132.569 155.019 1.00 34.34  ? 315 VAL A C   1 
ATOM   2363 O O   . VAL A 1 315 ? 122.388 133.297 155.997 1.00 34.34  ? 315 VAL A O   1 
ATOM   2364 C CB  . VAL A 1 315 ? 124.914 131.764 155.436 1.00 34.34  ? 315 VAL A CB  1 
ATOM   2365 C CG1 . VAL A 1 315 ? 124.325 130.484 155.949 1.00 34.34  ? 315 VAL A CG1 1 
ATOM   2366 C CG2 . VAL A 1 315 ? 126.218 131.472 154.791 1.00 34.34  ? 315 VAL A CG2 1 
ATOM   2367 N N   . SER A 1 316 ? 121.607 131.876 154.441 1.00 34.12  ? 316 SER A N   1 
ATOM   2368 C CA  . SER A 1 316 ? 120.251 131.868 154.967 1.00 34.12  ? 316 SER A CA  1 
ATOM   2369 C C   . SER A 1 316 ? 120.141 130.831 156.071 1.00 34.12  ? 316 SER A C   1 
ATOM   2370 O O   . SER A 1 316 ? 120.321 129.637 155.824 1.00 34.12  ? 316 SER A O   1 
ATOM   2371 C CB  . SER A 1 316 ? 119.257 131.567 153.855 1.00 34.12  ? 316 SER A CB  1 
ATOM   2372 O OG  . SER A 1 316 ? 117.953 131.442 154.375 1.00 34.12  ? 316 SER A OG  1 
ATOM   2373 N N   . VAL A 1 317 ? 119.835 131.284 157.282 1.00 34.64  ? 317 VAL A N   1 
ATOM   2374 C CA  . VAL A 1 317 ? 119.758 130.441 158.469 1.00 34.64  ? 317 VAL A CA  1 
ATOM   2375 C C   . VAL A 1 317 ? 118.295 130.315 158.845 1.00 34.64  ? 317 VAL A C   1 
ATOM   2376 O O   . VAL A 1 317 ? 117.686 131.286 159.297 1.00 34.64  ? 317 VAL A O   1 
ATOM   2377 C CB  . VAL A 1 317 ? 120.566 131.031 159.622 1.00 34.64  ? 317 VAL A CB  1 
ATOM   2378 C CG1 . VAL A 1 317 ? 120.376 130.214 160.858 1.00 34.64  ? 317 VAL A CG1 1 
ATOM   2379 C CG2 . VAL A 1 317 ? 122.019 131.110 159.246 1.00 34.64  ? 317 VAL A CG2 1 
ATOM   2380 N N   . SER A 1 318 ? 117.725 129.130 158.676 1.00 37.92  ? 318 SER A N   1 
ATOM   2381 C CA  . SER A 1 318 ? 116.306 128.901 158.912 1.00 37.92  ? 318 SER A CA  1 
ATOM   2382 C C   . SER A 1 318 ? 116.129 127.883 160.029 1.00 37.92  ? 318 SER A C   1 
ATOM   2383 O O   . SER A 1 318 ? 116.670 126.780 159.952 1.00 37.92  ? 318 SER A O   1 
ATOM   2384 C CB  . SER A 1 318 ? 115.622 128.413 157.641 1.00 37.92  ? 318 SER A CB  1 
ATOM   2385 O OG  . SER A 1 318 ? 115.701 129.395 156.631 1.00 37.92  ? 318 SER A OG  1 
ATOM   2386 N N   . LEU A 1 319 ? 115.362 128.246 161.051 1.00 39.25  ? 319 LEU A N   1 
ATOM   2387 C CA  . LEU A 1 319 ? 115.123 127.380 162.194 1.00 39.25  ? 319 LEU A CA  1 
ATOM   2388 C C   . LEU A 1 319 ? 113.792 126.664 162.034 1.00 39.25  ? 319 LEU A C   1 
ATOM   2389 O O   . LEU A 1 319 ? 112.765 127.308 161.829 1.00 39.25  ? 319 LEU A O   1 
ATOM   2390 C CB  . LEU A 1 319 ? 115.110 128.204 163.470 1.00 39.25  ? 319 LEU A CB  1 
ATOM   2391 C CG  . LEU A 1 319 ? 116.407 128.916 163.799 1.00 39.25  ? 319 LEU A CG  1 
ATOM   2392 C CD1 . LEU A 1 319 ? 116.192 129.859 164.943 1.00 39.25  ? 319 LEU A CD1 1 
ATOM   2393 C CD2 . LEU A 1 319 ? 117.436 127.910 164.168 1.00 39.25  ? 319 LEU A CD2 1 
ATOM   2394 N N   . GLN A 1 320 ? 113.801 125.342 162.151 1.00 40.11  ? 320 GLN A N   1 
ATOM   2395 C CA  . GLN A 1 320 ? 112.580 124.576 161.960 1.00 40.11  ? 320 GLN A CA  1 
ATOM   2396 C C   . GLN A 1 320 ? 111.698 124.627 163.192 1.00 40.11  ? 320 GLN A C   1 
ATOM   2397 O O   . GLN A 1 320 ? 112.146 124.400 164.314 1.00 40.11  ? 320 GLN A O   1 
ATOM   2398 C CB  . GLN A 1 320 ? 112.888 123.118 161.628 1.00 40.11  ? 320 GLN A CB  1 
ATOM   2399 C CG  . GLN A 1 320 ? 111.641 122.265 161.414 1.00 40.11  ? 320 GLN A CG  1 
ATOM   2400 C CD  . GLN A 1 320 ? 111.930 120.851 161.016 1.00 40.11  ? 320 GLN A CD  1 
ATOM   2401 O OE1 . GLN A 1 320 ? 113.079 120.453 160.897 1.00 40.11  ? 320 GLN A OE1 1 
ATOM   2402 N NE2 . GLN A 1 320 ? 110.883 120.074 160.825 1.00 40.11  ? 320 GLN A NE2 1 
ATOM   2403 N N   . ARG A 1 321 ? 110.422 124.906 162.967 1.00 44.09  ? 321 ARG A N   1 
ATOM   2404 C CA  . ARG A 1 321 ? 109.427 124.937 164.021 1.00 44.09  ? 321 ARG A CA  1 
ATOM   2405 C C   . ARG A 1 321 ? 108.426 123.814 163.801 1.00 44.09  ? 321 ARG A C   1 
ATOM   2406 O O   . ARG A 1 321 ? 108.295 123.278 162.702 1.00 44.09  ? 321 ARG A O   1 
ATOM   2407 C CB  . ARG A 1 321 ? 108.726 126.291 164.060 1.00 44.09  ? 321 ARG A CB  1 
ATOM   2408 C CG  . ARG A 1 321 ? 109.667 127.429 164.368 1.00 44.09  ? 321 ARG A CG  1 
ATOM   2409 C CD  . ARG A 1 321 ? 110.076 127.389 165.815 1.00 44.09  ? 321 ARG A CD  1 
ATOM   2410 N NE  . ARG A 1 321 ? 110.956 128.493 166.161 1.00 44.09  ? 321 ARG A NE  1 
ATOM   2411 C CZ  . ARG A 1 321 ? 112.280 128.407 166.169 1.00 44.09  ? 321 ARG A CZ  1 
ATOM   2412 N NH1 . ARG A 1 321 ? 112.869 127.261 165.865 1.00 44.09  ? 321 ARG A NH1 1 
ATOM   2413 N NH2 . ARG A 1 321 ? 113.015 129.461 166.495 1.00 44.09  ? 321 ARG A NH2 1 
ATOM   2414 N N   . ALA A 1 322 ? 107.709 123.470 164.868 1.00 45.57  ? 322 ALA A N   1 
ATOM   2415 C CA  . ALA A 1 322 ? 106.893 122.264 164.852 1.00 45.57  ? 322 ALA A CA  1 
ATOM   2416 C C   . ALA A 1 322 ? 105.616 122.444 164.051 1.00 45.57  ? 322 ALA A C   1 
ATOM   2417 O O   . ALA A 1 322 ? 105.005 121.453 163.637 1.00 45.57  ? 322 ALA A O   1 
ATOM   2418 C CB  . ALA A 1 322 ? 106.555 121.841 166.278 1.00 45.57  ? 322 ALA A CB  1 
ATOM   2419 N N   . SER A 1 323 ? 105.191 123.685 163.826 1.00 47.59  ? 323 SER A N   1 
ATOM   2420 C CA  . SER A 1 323 ? 103.971 123.921 163.067 1.00 47.59  ? 323 SER A CA  1 
ATOM   2421 C C   . SER A 1 323 ? 104.165 123.702 161.576 1.00 47.59  ? 323 SER A C   1 
ATOM   2422 O O   . SER A 1 323 ? 103.180 123.519 160.856 1.00 47.59  ? 323 SER A O   1 
ATOM   2423 C CB  . SER A 1 323 ? 103.463 125.338 163.322 1.00 47.59  ? 323 SER A CB  1 
ATOM   2424 O OG  . SER A 1 323 ? 104.378 126.301 162.833 1.00 47.59  ? 323 SER A OG  1 
ATOM   2425 N N   . GLY A 1 324 ? 105.404 123.717 161.100 1.00 46.12  ? 324 GLY A N   1 
ATOM   2426 C CA  . GLY A 1 324 ? 105.709 123.591 159.687 1.00 46.12  ? 324 GLY A CA  1 
ATOM   2427 C C   . GLY A 1 324 ? 106.410 124.791 159.090 1.00 46.12  ? 324 GLY A C   1 
ATOM   2428 O O   . GLY A 1 324 ? 107.115 124.638 158.083 1.00 46.12  ? 324 GLY A O   1 
ATOM   2429 N N   . ASP A 1 325 ? 106.254 125.976 159.662 1.00 43.31  ? 325 ASP A N   1 
ATOM   2430 C CA  . ASP A 1 325 ? 106.899 127.171 159.160 1.00 43.31  ? 325 ASP A CA  1 
ATOM   2431 C C   . ASP A 1 325 ? 108.296 127.267 159.748 1.00 43.31  ? 325 ASP A C   1 
ATOM   2432 O O   . ASP A 1 325 ? 108.598 126.685 160.787 1.00 43.31  ? 325 ASP A O   1 
ATOM   2433 C CB  . ASP A 1 325 ? 106.068 128.408 159.497 1.00 43.31  ? 325 ASP A CB  1 
ATOM   2434 N N   . PHE A 1 326 ? 109.171 127.994 159.066 1.00 40.13  ? 326 PHE A N   1 
ATOM   2435 C CA  . PHE A 1 326 ? 110.545 128.135 159.511 1.00 40.13  ? 326 PHE A CA  1 
ATOM   2436 C C   . PHE A 1 326 ? 110.788 129.584 159.880 1.00 40.13  ? 326 PHE A C   1 
ATOM   2437 O O   . PHE A 1 326 ? 110.011 130.467 159.519 1.00 40.13  ? 326 PHE A O   1 
ATOM   2438 C CB  . PHE A 1 326 ? 111.580 127.724 158.450 1.00 40.13  ? 326 PHE A CB  1 
ATOM   2439 C CG  . PHE A 1 326 ? 111.585 126.249 158.090 1.00 40.13  ? 326 PHE A CG  1 
ATOM   2440 C CD1 . PHE A 1 326 ? 110.841 125.315 158.774 1.00 40.13  ? 326 PHE A CD1 1 
ATOM   2441 C CD2 . PHE A 1 326 ? 112.396 125.808 157.084 1.00 40.13  ? 326 PHE A CD2 1 
ATOM   2442 C CE1 . PHE A 1 326 ? 110.871 123.996 158.411 1.00 40.13  ? 326 PHE A CE1 1 
ATOM   2443 C CE2 . PHE A 1 326 ? 112.440 124.493 156.730 1.00 40.13  ? 326 PHE A CE2 1 
ATOM   2444 C CZ  . PHE A 1 326 ? 111.682 123.589 157.394 1.00 40.13  ? 326 PHE A CZ  1 
ATOM   2445 N N   . GLN A 1 327 ? 111.876 129.824 160.593 1.00 41.20  ? 327 GLN A N   1 
ATOM   2446 C CA  . GLN A 1 327 ? 112.246 131.157 161.050 1.00 41.20  ? 327 GLN A CA  1 
ATOM   2447 C C   . GLN A 1 327 ? 113.593 131.523 160.442 1.00 41.20  ? 327 GLN A C   1 
ATOM   2448 O O   . GLN A 1 327 ? 114.638 131.101 160.939 1.00 41.20  ? 327 GLN A O   1 
ATOM   2449 C CB  . GLN A 1 327 ? 112.293 131.204 162.572 1.00 41.20  ? 327 GLN A CB  1 
ATOM   2450 C CG  . GLN A 1 327 ? 112.579 132.574 163.133 1.00 41.20  ? 327 GLN A CG  1 
ATOM   2451 C CD  . GLN A 1 327 ? 112.546 132.593 164.640 1.00 41.20  ? 327 GLN A CD  1 
ATOM   2452 O OE1 . GLN A 1 327 ? 112.327 131.566 165.277 1.00 41.20  ? 327 GLN A OE1 1 
ATOM   2453 N NE2 . GLN A 1 327 ? 112.769 133.763 165.223 1.00 41.20  ? 327 GLN A NE2 1 
ATOM   2454 N N   . THR A 1 328 ? 113.569 132.323 159.387 1.00 38.53  ? 328 THR A N   1 
ATOM   2455 C CA  . THR A 1 328 ? 114.741 132.575 158.564 1.00 38.53  ? 328 THR A CA  1 
ATOM   2456 C C   . THR A 1 328 ? 115.372 133.906 158.940 1.00 38.53  ? 328 THR A C   1 
ATOM   2457 O O   . THR A 1 328 ? 114.742 134.956 158.802 1.00 38.53  ? 328 THR A O   1 
ATOM   2458 C CB  . THR A 1 328 ? 114.373 132.569 157.083 1.00 38.53  ? 328 THR A CB  1 
ATOM   2459 O OG1 . THR A 1 328 ? 113.849 131.288 156.718 1.00 38.53  ? 328 THR A OG1 1 
ATOM   2460 C CG2 . THR A 1 328 ? 115.590 132.868 156.236 1.00 38.53  ? 328 THR A CG2 1 
ATOM   2461 N N   . THR A 1 329 ? 116.608 133.858 159.412 1.00 35.72  ? 329 THR A N   1 
ATOM   2462 C CA  . THR A 1 329 ? 117.452 135.028 159.551 1.00 35.72  ? 329 THR A CA  1 
ATOM   2463 C C   . THR A 1 329 ? 118.621 134.889 158.592 1.00 35.72  ? 329 THR A C   1 
ATOM   2464 O O   . THR A 1 329 ? 118.870 133.819 158.039 1.00 35.72  ? 329 THR A O   1 
ATOM   2465 C CB  . THR A 1 329 ? 117.958 135.180 160.978 1.00 35.72  ? 329 THR A CB  1 
ATOM   2466 O OG1 . THR A 1 329 ? 118.781 134.058 161.305 1.00 35.72  ? 329 THR A OG1 1 
ATOM   2467 C CG2 . THR A 1 329 ? 116.791 135.238 161.941 1.00 35.72  ? 329 THR A CG2 1 
ATOM   2468 N N   . LYS A 1 330 ? 119.347 135.978 158.382 1.00 34.13  ? 330 LYS A N   1 
ATOM   2469 C CA  . LYS A 1 330 ? 120.306 136.034 157.293 1.00 34.13  ? 330 LYS A CA  1 
ATOM   2470 C C   . LYS A 1 330 ? 121.638 136.539 157.803 1.00 34.13  ? 330 LYS A C   1 
ATOM   2471 O O   . LYS A 1 330 ? 121.685 137.495 158.574 1.00 34.13  ? 330 LYS A O   1 
ATOM   2472 C CB  . LYS A 1 330 ? 119.779 136.927 156.169 1.00 34.13  ? 330 LYS A CB  1 
ATOM   2473 C CG  . LYS A 1 330 ? 118.612 136.303 155.419 1.00 34.13  ? 330 LYS A CG  1 
ATOM   2474 C CD  . LYS A 1 330 ? 117.987 137.223 154.421 1.00 34.13  ? 330 LYS A CD  1 
ATOM   2475 C CE  . LYS A 1 330 ? 116.879 136.517 153.698 1.00 34.13  ? 330 LYS A CE  1 
ATOM   2476 N NZ  . LYS A 1 330 ? 116.246 137.385 152.678 1.00 34.13  ? 330 LYS A NZ  1 
ATOM   2477 N N   . LEU A 1 331 ? 122.712 135.901 157.365 1.00 34.72  ? 331 LEU A N   1 
ATOM   2478 C CA  . LEU A 1 331 ? 124.053 136.166 157.857 1.00 34.72  ? 331 LEU A CA  1 
ATOM   2479 C C   . LEU A 1 331 ? 124.925 136.551 156.678 1.00 34.72  ? 331 LEU A C   1 
ATOM   2480 O O   . LEU A 1 331 ? 125.051 135.778 155.729 1.00 34.72  ? 331 LEU A O   1 
ATOM   2481 C CB  . LEU A 1 331 ? 124.615 134.936 158.565 1.00 34.72  ? 331 LEU A CB  1 
ATOM   2482 C CG  . LEU A 1 331 ? 126.001 134.992 159.196 1.00 34.72  ? 331 LEU A CG  1 
ATOM   2483 C CD1 . LEU A 1 331 ? 126.045 135.994 160.316 1.00 34.72  ? 331 LEU A CD1 1 
ATOM   2484 C CD2 . LEU A 1 331 ? 126.361 133.621 159.699 1.00 34.72  ? 331 LEU A CD2 1 
ATOM   2485 N N   . ASN A 1 332 ? 125.528 137.731 156.738 1.00 34.86  ? 332 ASN A N   1 
ATOM   2486 C CA  . ASN A 1 332 ? 126.262 138.282 155.611 1.00 34.86  ? 332 ASN A CA  1 
ATOM   2487 C C   . ASN A 1 332 ? 127.758 138.121 155.800 1.00 34.86  ? 332 ASN A C   1 
ATOM   2488 O O   . ASN A 1 332 ? 128.252 137.931 156.908 1.00 34.86  ? 332 ASN A O   1 
ATOM   2489 C CB  . ASN A 1 332 ? 125.932 139.760 155.416 1.00 34.86  ? 332 ASN A CB  1 
ATOM   2490 C CG  . ASN A 1 332 ? 124.560 139.980 154.841 1.00 34.86  ? 332 ASN A CG  1 
ATOM   2491 O OD1 . ASN A 1 332 ? 124.162 139.322 153.898 1.00 34.86  ? 332 ASN A OD1 1 
ATOM   2492 N ND2 . ASN A 1 332 ? 123.825 140.909 155.417 1.00 34.86  ? 332 ASN A ND2 1 
ATOM   2493 N N   . GLY A 1 333 ? 128.479 138.229 154.694 1.00 36.49  ? 333 GLY A N   1 
ATOM   2494 C CA  . GLY A 1 333 ? 129.906 138.043 154.693 1.00 36.49  ? 333 GLY A CA  1 
ATOM   2495 C C   . GLY A 1 333 ? 130.623 139.290 155.130 1.00 36.49  ? 333 GLY A C   1 
ATOM   2496 O O   . GLY A 1 333 ? 130.025 140.290 155.517 1.00 36.49  ? 333 GLY A O   1 
ATOM   2497 N N   . PHE A 1 334 ? 131.947 139.224 155.073 1.00 42.15  ? 334 PHE A N   1 
ATOM   2498 C CA  . PHE A 1 334 ? 132.772 140.301 155.607 1.00 42.15  ? 334 PHE A CA  1 
ATOM   2499 C C   . PHE A 1 334 ? 133.574 141.019 154.535 1.00 42.15  ? 334 PHE A C   1 
ATOM   2500 O O   . PHE A 1 334 ? 133.455 142.239 154.397 1.00 42.15  ? 334 PHE A O   1 
ATOM   2501 C CB  . PHE A 1 334 ? 133.735 139.774 156.692 1.00 42.15  ? 334 PHE A CB  1 
ATOM   2502 C CG  . PHE A 1 334 ? 133.056 139.253 157.945 1.00 42.15  ? 334 PHE A CG  1 
ATOM   2503 C CD1 . PHE A 1 334 ? 131.746 139.571 158.256 1.00 42.15  ? 334 PHE A CD1 1 
ATOM   2504 C CD2 . PHE A 1 334 ? 133.749 138.437 158.807 1.00 42.15  ? 334 PHE A CD2 1 
ATOM   2505 C CE1 . PHE A 1 334 ? 131.144 139.069 159.381 1.00 42.15  ? 334 PHE A CE1 1 
ATOM   2506 C CE2 . PHE A 1 334 ? 133.153 137.938 159.938 1.00 42.15  ? 334 PHE A CE2 1 
ATOM   2507 C CZ  . PHE A 1 334 ? 131.850 138.257 160.224 1.00 42.15  ? 334 PHE A CZ  1 
ATOM   2508 N N   . GLU A 1 335 ? 134.398 140.306 153.775 1.00 40.88  ? 335 GLU A N   1 
ATOM   2509 C CA  . GLU A 1 335 ? 135.231 140.911 152.749 1.00 40.88  ? 335 GLU A CA  1 
ATOM   2510 C C   . GLU A 1 335 ? 134.587 140.727 151.386 1.00 40.88  ? 335 GLU A C   1 
ATOM   2511 O O   . GLU A 1 335 ? 133.881 139.747 151.142 1.00 40.88  ? 335 GLU A O   1 
ATOM   2512 C CB  . GLU A 1 335 ? 136.629 140.309 152.737 1.00 40.88  ? 335 GLU A CB  1 
ATOM   2513 N N   . VAL A 1 336 ? 134.835 141.685 150.495 1.00 42.21  ? 336 VAL A N   1 
ATOM   2514 C CA  . VAL A 1 336 ? 134.246 141.642 149.165 1.00 42.21  ? 336 VAL A CA  1 
ATOM   2515 C C   . VAL A 1 336 ? 134.994 140.623 148.318 1.00 42.21  ? 336 VAL A C   1 
ATOM   2516 O O   . VAL A 1 336 ? 136.194 140.389 148.512 1.00 42.21  ? 336 VAL A O   1 
ATOM   2517 C CB  . VAL A 1 336 ? 134.245 143.052 148.539 1.00 42.21  ? 336 VAL A CB  1 
ATOM   2518 C CG1 . VAL A 1 336 ? 135.658 143.558 148.254 1.00 42.21  ? 336 VAL A CG1 1 
ATOM   2519 C CG2 . VAL A 1 336 ? 133.361 143.124 147.292 1.00 42.21  ? 336 VAL A CG2 1 
ATOM   2520 N N   . PHE A 1 337 ? 134.255 139.938 147.445 1.00 40.89  ? 337 PHE A N   1 
ATOM   2521 C CA  . PHE A 1 337 ? 134.719 138.910 146.514 1.00 40.89  ? 337 PHE A CA  1 
ATOM   2522 C C   . PHE A 1 337 ? 135.300 137.686 147.209 1.00 40.89  ? 337 PHE A C   1 
ATOM   2523 O O   . PHE A 1 337 ? 135.980 136.885 146.563 1.00 40.89  ? 337 PHE A O   1 
ATOM   2524 C CB  . PHE A 1 337 ? 135.748 139.461 145.517 1.00 40.89  ? 337 PHE A CB  1 
ATOM   2525 C CG  . PHE A 1 337 ? 135.188 140.447 144.537 1.00 40.89  ? 337 PHE A CG  1 
ATOM   2526 C CD1 . PHE A 1 337 ? 133.846 140.466 144.231 1.00 40.89  ? 337 PHE A CD1 1 
ATOM   2527 C CD2 . PHE A 1 337 ? 136.012 141.380 143.952 1.00 40.89  ? 337 PHE A CD2 1 
ATOM   2528 C CE1 . PHE A 1 337 ? 133.353 141.372 143.344 1.00 40.89  ? 337 PHE A CE1 1 
ATOM   2529 C CE2 . PHE A 1 337 ? 135.514 142.289 143.064 1.00 40.89  ? 337 PHE A CE2 1 
ATOM   2530 C CZ  . PHE A 1 337 ? 134.185 142.283 142.763 1.00 40.89  ? 337 PHE A CZ  1 
ATOM   2531 N N   . ALA A 1 338 ? 135.047 137.509 148.502 1.00 38.12  ? 338 ALA A N   1 
ATOM   2532 C CA  . ALA A 1 338 ? 135.632 136.408 149.245 1.00 38.12  ? 338 ALA A CA  1 
ATOM   2533 C C   . ALA A 1 338 ? 134.755 135.174 149.255 1.00 38.12  ? 338 ALA A C   1 
ATOM   2534 O O   . ALA A 1 338 ? 135.214 134.127 149.710 1.00 38.12  ? 338 ALA A O   1 
ATOM   2535 C CB  . ALA A 1 338 ? 135.917 136.836 150.679 1.00 38.12  ? 338 ALA A CB  1 
ATOM   2536 N N   . ARG A 1 339 ? 133.513 135.296 148.791 1.00 37.12  ? 339 ARG A N   1 
ATOM   2537 C CA  . ARG A 1 339 ? 132.573 134.194 148.593 1.00 37.12  ? 339 ARG A CA  1 
ATOM   2538 C C   . ARG A 1 339 ? 132.252 133.482 149.904 1.00 37.12  ? 339 ARG A C   1 
ATOM   2539 O O   . ARG A 1 339 ? 132.507 132.297 150.090 1.00 37.12  ? 339 ARG A O   1 
ATOM   2540 C CB  . ARG A 1 339 ? 133.078 133.230 147.519 1.00 37.12  ? 339 ARG A CB  1 
ATOM   2541 C CG  . ARG A 1 339 ? 133.089 133.877 146.166 1.00 37.12  ? 339 ARG A CG  1 
ATOM   2542 C CD  . ARG A 1 339 ? 133.547 132.943 145.106 1.00 37.12  ? 339 ARG A CD  1 
ATOM   2543 N NE  . ARG A 1 339 ? 133.489 133.580 143.800 1.00 37.12  ? 339 ARG A NE  1 
ATOM   2544 C CZ  . ARG A 1 339 ? 133.841 132.988 142.668 1.00 37.12  ? 339 ARG A CZ  1 
ATOM   2545 N NH1 . ARG A 1 339 ? 134.278 131.738 142.682 1.00 37.12  ? 339 ARG A NH1 1 
ATOM   2546 N NH2 . ARG A 1 339 ? 133.750 133.643 141.522 1.00 37.12  ? 339 ARG A NH2 1 
ATOM   2547 N N   . PHE A 1 340 ? 131.682 134.258 150.812 1.00 36.92  ? 340 PHE A N   1 
ATOM   2548 C CA  . PHE A 1 340 ? 131.130 133.748 152.055 1.00 36.92  ? 340 PHE A CA  1 
ATOM   2549 C C   . PHE A 1 340 ? 129.932 132.871 151.763 1.00 36.92  ? 340 PHE A C   1 
ATOM   2550 O O   . PHE A 1 340 ? 129.058 133.244 150.983 1.00 36.92  ? 340 PHE A O   1 
ATOM   2551 C CB  . PHE A 1 340 ? 130.716 134.925 152.925 1.00 36.92  ? 340 PHE A CB  1 
ATOM   2552 C CG  . PHE A 1 340 ? 130.154 134.564 154.256 1.00 36.92  ? 340 PHE A CG  1 
ATOM   2553 C CD1 . PHE A 1 340 ? 130.988 134.277 155.316 1.00 36.92  ? 340 PHE A CD1 1 
ATOM   2554 C CD2 . PHE A 1 340 ? 128.794 134.570 154.463 1.00 36.92  ? 340 PHE A CD2 1 
ATOM   2555 C CE1 . PHE A 1 340 ? 130.470 133.979 156.541 1.00 36.92  ? 340 PHE A CE1 1 
ATOM   2556 C CE2 . PHE A 1 340 ? 128.276 134.273 155.681 1.00 36.92  ? 340 PHE A CE2 1 
ATOM   2557 C CZ  . PHE A 1 340 ? 129.110 133.974 156.722 1.00 36.92  ? 340 PHE A CZ  1 
ATOM   2558 N N   . GLY A 1 341 ? 129.877 131.714 152.394 1.00 36.38  ? 341 GLY A N   1 
ATOM   2559 C CA  . GLY A 1 341 ? 128.764 130.825 152.190 1.00 36.38  ? 341 GLY A CA  1 
ATOM   2560 C C   . GLY A 1 341 ? 128.942 129.842 151.071 1.00 36.38  ? 341 GLY A C   1 
ATOM   2561 O O   . GLY A 1 341 ? 127.955 129.257 150.623 1.00 36.38  ? 341 GLY A O   1 
ATOM   2562 N N   . SER A 1 342 ? 130.164 129.651 150.591 1.00 36.44  ? 342 SER A N   1 
ATOM   2563 C CA  . SER A 1 342 ? 130.391 128.632 149.582 1.00 36.44  ? 342 SER A CA  1 
ATOM   2564 C C   . SER A 1 342 ? 130.376 127.239 150.189 1.00 36.44  ? 342 SER A C   1 
ATOM   2565 O O   . SER A 1 342 ? 130.008 126.272 149.515 1.00 36.44  ? 342 SER A O   1 
ATOM   2566 C CB  . SER A 1 342 ? 131.714 128.891 148.877 1.00 36.44  ? 342 SER A CB  1 
ATOM   2567 O OG  . SER A 1 342 ? 132.789 128.698 149.769 1.00 36.44  ? 342 SER A OG  1 
ATOM   2568 N N   . ALA A 1 343 ? 130.750 127.119 151.460 1.00 37.99  ? 343 ALA A N   1 
ATOM   2569 C CA  . ALA A 1 343 ? 130.791 125.841 152.153 1.00 37.99  ? 343 ALA A CA  1 
ATOM   2570 C C   . ALA A 1 343 ? 130.161 126.016 153.522 1.00 37.99  ? 343 ALA A C   1 
ATOM   2571 O O   . ALA A 1 343 ? 130.630 126.825 154.324 1.00 37.99  ? 343 ALA A O   1 
ATOM   2572 C CB  . ALA A 1 343 ? 132.226 125.328 152.286 1.00 37.99  ? 343 ALA A CB  1 
ATOM   2573 N N   . ILE A 1 344 ? 129.094 125.272 153.775 1.00 38.38  ? 344 ILE A N   1 
ATOM   2574 C CA  . ILE A 1 344 ? 128.450 125.232 155.077 1.00 38.38  ? 344 ILE A CA  1 
ATOM   2575 C C   . ILE A 1 344 ? 128.798 123.884 155.683 1.00 38.38  ? 344 ILE A C   1 
ATOM   2576 O O   . ILE A 1 344 ? 128.350 122.846 155.184 1.00 38.38  ? 344 ILE A O   1 
ATOM   2577 C CB  . ILE A 1 344 ? 126.926 125.395 154.970 1.00 38.38  ? 344 ILE A CB  1 
ATOM   2578 C CG1 . ILE A 1 344 ? 126.527 126.493 153.984 1.00 38.38  ? 344 ILE A CG1 1 
ATOM   2579 C CG2 . ILE A 1 344 ? 126.366 125.769 156.322 1.00 38.38  ? 344 ILE A CG2 1 
ATOM   2580 C CD1 . ILE A 1 344 ? 126.980 127.857 154.352 1.00 38.38  ? 344 ILE A CD1 1 
ATOM   2581 N N   . ALA A 1 345 ? 129.594 123.884 156.750 1.00 40.99  ? 345 ALA A N   1 
ATOM   2582 C CA  . ALA A 1 345 ? 130.075 122.646 157.368 1.00 40.99  ? 345 ALA A CA  1 
ATOM   2583 C C   . ALA A 1 345 ? 129.517 122.492 158.770 1.00 40.99  ? 345 ALA A C   1 
ATOM   2584 O O   . ALA A 1 345 ? 129.919 123.235 159.680 1.00 40.99  ? 345 ALA A O   1 
ATOM   2585 C CB  . ALA A 1 345 ? 131.599 122.620 157.409 1.00 40.99  ? 345 ALA A CB  1 
ATOM   2586 N N   . PRO A 1 346 ? 128.600 121.554 159.001 1.00 39.56  ? 346 PRO A N   1 
ATOM   2587 C CA  . PRO A 1 346 ? 128.139 121.293 160.367 1.00 39.56  ? 346 PRO A CA  1 
ATOM   2588 C C   . PRO A 1 346 ? 129.229 120.653 161.210 1.00 39.56  ? 346 PRO A C   1 
ATOM   2589 O O   . PRO A 1 346 ? 129.768 119.604 160.867 1.00 39.56  ? 346 PRO A O   1 
ATOM   2590 C CB  . PRO A 1 346 ? 126.959 120.346 160.156 1.00 39.56  ? 346 PRO A CB  1 
ATOM   2591 C CG  . PRO A 1 346 ? 126.529 120.598 158.797 1.00 39.56  ? 346 PRO A CG  1 
ATOM   2592 C CD  . PRO A 1 346 ? 127.745 120.884 158.017 1.00 39.56  ? 346 PRO A CD  1 
ATOM   2593 N N   . LEU A 1 347 ? 129.551 121.297 162.322 1.00 44.91  ? 347 LEU A N   1 
ATOM   2594 C CA  . LEU A 1 347 ? 130.609 120.853 163.213 1.00 44.91  ? 347 LEU A CA  1 
ATOM   2595 C C   . LEU A 1 347 ? 130.136 119.930 164.323 1.00 44.91  ? 347 LEU A C   1 
ATOM   2596 O O   . LEU A 1 347 ? 130.972 119.327 164.997 1.00 44.91  ? 347 LEU A O   1 
ATOM   2597 C CB  . LEU A 1 347 ? 131.283 122.056 163.858 1.00 44.91  ? 347 LEU A CB  1 
ATOM   2598 C CG  . LEU A 1 347 ? 132.132 122.925 162.956 1.00 44.91  ? 347 LEU A CG  1 
ATOM   2599 C CD1 . LEU A 1 347 ? 132.593 124.151 163.710 1.00 44.91  ? 347 LEU A CD1 1 
ATOM   2600 C CD2 . LEU A 1 347 ? 133.301 122.107 162.506 1.00 44.91  ? 347 LEU A CD2 1 
ATOM   2601 N N   . GLY A 1 348 ? 128.844 119.816 164.549 1.00 45.70  ? 348 GLY A N   1 
ATOM   2602 C CA  . GLY A 1 348 ? 128.421 119.188 165.769 1.00 45.70  ? 348 GLY A CA  1 
ATOM   2603 C C   . GLY A 1 348 ? 128.677 120.134 166.929 1.00 45.70  ? 348 GLY A C   1 
ATOM   2604 O O   . GLY A 1 348 ? 128.866 121.332 166.769 1.00 45.70  ? 348 GLY A O   1 
ATOM   2605 N N   . ASP A 1 349 ? 128.689 119.562 168.126 1.00 48.52  ? 349 ASP A N   1 
ATOM   2606 C CA  . ASP A 1 349 ? 128.858 120.350 169.340 1.00 48.52  ? 349 ASP A CA  1 
ATOM   2607 C C   . ASP A 1 349 ? 130.350 120.487 169.608 1.00 48.52  ? 349 ASP A C   1 
ATOM   2608 O O   . ASP A 1 349 ? 130.939 119.747 170.396 1.00 48.52  ? 349 ASP A O   1 
ATOM   2609 C CB  . ASP A 1 349 ? 128.132 119.684 170.496 1.00 48.52  ? 349 ASP A CB  1 
ATOM   2610 C CG  . ASP A 1 349 ? 127.961 120.593 171.677 1.00 48.52  ? 349 ASP A CG  1 
ATOM   2611 O OD1 . ASP A 1 349 ? 128.373 121.761 171.596 1.00 48.52  ? 349 ASP A OD1 1 
ATOM   2612 O OD2 . ASP A 1 349 ? 127.415 120.135 172.701 1.00 48.52  ? 349 ASP A OD2 1 
ATOM   2613 N N   . LEU A 1 350 ? 130.961 121.463 168.935 1.00 49.07  ? 350 LEU A N   1 
ATOM   2614 C CA  . LEU A 1 350 ? 132.411 121.627 168.965 1.00 49.07  ? 350 LEU A CA  1 
ATOM   2615 C C   . LEU A 1 350 ? 132.902 122.014 170.348 1.00 49.07  ? 350 LEU A C   1 
ATOM   2616 O O   . LEU A 1 350 ? 133.933 121.520 170.815 1.00 49.07  ? 350 LEU A O   1 
ATOM   2617 C CB  . LEU A 1 350 ? 132.831 122.685 167.950 1.00 49.07  ? 350 LEU A CB  1 
ATOM   2618 C CG  . LEU A 1 350 ? 134.302 123.063 167.841 1.00 49.07  ? 350 LEU A CG  1 
ATOM   2619 C CD1 . LEU A 1 350 ? 135.049 121.930 167.253 1.00 49.07  ? 350 LEU A CD1 1 
ATOM   2620 C CD2 . LEU A 1 350 ? 134.491 124.309 167.007 1.00 49.07  ? 350 LEU A CD2 1 
ATOM   2621 N N   . ASP A 1 351 ? 132.174 122.896 171.018 1.00 50.62  ? 351 ASP A N   1 
ATOM   2622 C CA  . ASP A 1 351 ? 132.538 123.390 172.339 1.00 50.62  ? 351 ASP A CA  1 
ATOM   2623 C C   . ASP A 1 351 ? 131.991 122.544 173.479 1.00 50.62  ? 351 ASP A C   1 
ATOM   2624 O O   . ASP A 1 351 ? 132.329 122.818 174.633 1.00 50.62  ? 351 ASP A O   1 
ATOM   2625 C CB  . ASP A 1 351 ? 132.080 124.845 172.485 1.00 50.62  ? 351 ASP A CB  1 
ATOM   2626 C CG  . ASP A 1 351 ? 130.634 125.064 172.057 1.00 50.62  ? 351 ASP A CG  1 
ATOM   2627 O OD1 . ASP A 1 351 ? 129.974 124.131 171.568 1.00 50.62  ? 351 ASP A OD1 1 
ATOM   2628 O OD2 . ASP A 1 351 ? 130.159 126.202 172.196 1.00 50.62  ? 351 ASP A OD2 1 
ATOM   2629 N N   . GLN A 1 352 ? 131.195 121.516 173.168 1.00 49.78  ? 352 GLN A N   1 
ATOM   2630 C CA  . GLN A 1 352 ? 130.518 120.651 174.140 1.00 49.78  ? 352 GLN A CA  1 
ATOM   2631 C C   . GLN A 1 352 ? 129.687 121.465 175.125 1.00 49.78  ? 352 GLN A C   1 
ATOM   2632 O O   . GLN A 1 352 ? 129.746 121.270 176.338 1.00 49.78  ? 352 GLN A O   1 
ATOM   2633 C CB  . GLN A 1 352 ? 131.503 119.738 174.871 1.00 49.78  ? 352 GLN A CB  1 
ATOM   2634 N N   . ASP A 1 353 ? 128.901 122.389 174.583 1.00 50.23  ? 353 ASP A N   1 
ATOM   2635 C CA  . ASP A 1 353 ? 128.070 123.273 175.378 1.00 50.23  ? 353 ASP A CA  1 
ATOM   2636 C C   . ASP A 1 353 ? 126.592 122.951 175.269 1.00 50.23  ? 353 ASP A C   1 
ATOM   2637 O O   . ASP A 1 353 ? 125.785 123.593 175.942 1.00 50.23  ? 353 ASP A O   1 
ATOM   2638 C CB  . ASP A 1 353 ? 128.309 124.729 174.971 1.00 50.23  ? 353 ASP A CB  1 
ATOM   2639 N N   . GLY A 1 354 ? 126.214 121.982 174.448 1.00 48.15  ? 354 GLY A N   1 
ATOM   2640 C CA  . GLY A 1 354 ? 124.827 121.595 174.318 1.00 48.15  ? 354 GLY A CA  1 
ATOM   2641 C C   . GLY A 1 354 ? 124.137 122.130 173.091 1.00 48.15  ? 354 GLY A C   1 
ATOM   2642 O O   . GLY A 1 354 ? 122.940 121.884 172.920 1.00 48.15  ? 354 GLY A O   1 
ATOM   2643 N N   . PHE A 1 355 ? 124.842 122.855 172.236 1.00 47.55  ? 355 PHE A N   1 
ATOM   2644 C CA  . PHE A 1 355 ? 124.288 123.388 171.005 1.00 47.55  ? 355 PHE A CA  1 
ATOM   2645 C C   . PHE A 1 355 ? 125.282 123.128 169.885 1.00 47.55  ? 355 PHE A C   1 
ATOM   2646 O O   . PHE A 1 355 ? 126.486 123.340 170.061 1.00 47.55  ? 355 PHE A O   1 
ATOM   2647 C CB  . PHE A 1 355 ? 124.030 124.884 171.113 1.00 47.55  ? 355 PHE A CB  1 
ATOM   2648 C CG  . PHE A 1 355 ? 123.163 125.270 172.267 1.00 47.55  ? 355 PHE A CG  1 
ATOM   2649 C CD1 . PHE A 1 355 ? 121.796 125.067 172.223 1.00 47.55  ? 355 PHE A CD1 1 
ATOM   2650 C CD2 . PHE A 1 355 ? 123.720 125.869 173.387 1.00 47.55  ? 355 PHE A CD2 1 
ATOM   2651 C CE1 . PHE A 1 355 ? 121.000 125.430 173.287 1.00 47.55  ? 355 PHE A CE1 1 
ATOM   2652 C CE2 . PHE A 1 355 ? 122.937 126.239 174.452 1.00 47.55  ? 355 PHE A CE2 1 
ATOM   2653 C CZ  . PHE A 1 355 ? 121.572 126.022 174.405 1.00 47.55  ? 355 PHE A CZ  1 
ATOM   2654 N N   . ASN A 1 356 ? 124.774 122.685 168.737 1.00 44.22  ? 356 ASN A N   1 
ATOM   2655 C CA  . ASN A 1 356 ? 125.626 122.366 167.605 1.00 44.22  ? 356 ASN A CA  1 
ATOM   2656 C C   . ASN A 1 356 ? 126.249 123.629 167.028 1.00 44.22  ? 356 ASN A C   1 
ATOM   2657 O O   . ASN A 1 356 ? 125.802 124.743 167.289 1.00 44.22  ? 356 ASN A O   1 
ATOM   2658 C CB  . ASN A 1 356 ? 124.839 121.641 166.524 1.00 44.22  ? 356 ASN A CB  1 
ATOM   2659 C CG  . ASN A 1 356 ? 124.473 120.246 166.922 1.00 44.22  ? 356 ASN A CG  1 
ATOM   2660 O OD1 . ASN A 1 356 ? 125.254 119.550 167.554 1.00 44.22  ? 356 ASN A OD1 1 
ATOM   2661 N ND2 . ASN A 1 356 ? 123.289 119.811 166.531 1.00 44.22  ? 356 ASN A ND2 1 
ATOM   2662 N N   . ASP A 1 357 ? 127.309 123.443 166.249 1.00 45.86  ? 357 ASP A N   1 
ATOM   2663 C CA  . ASP A 1 357 ? 128.086 124.536 165.692 1.00 45.86  ? 357 ASP A CA  1 
ATOM   2664 C C   . ASP A 1 357 ? 128.235 124.343 164.184 1.00 45.86  ? 357 ASP A C   1 
ATOM   2665 O O   . ASP A 1 357 ? 127.969 123.263 163.654 1.00 45.86  ? 357 ASP A O   1 
ATOM   2666 C CB  . ASP A 1 357 ? 129.445 124.600 166.376 1.00 45.86  ? 357 ASP A CB  1 
ATOM   2667 C CG  . ASP A 1 357 ? 129.328 124.837 167.855 1.00 45.86  ? 357 ASP A CG  1 
ATOM   2668 O OD1 . ASP A 1 357 ? 128.341 125.440 168.288 1.00 45.86  ? 357 ASP A OD1 1 
ATOM   2669 O OD2 . ASP A 1 357 ? 130.228 124.445 168.610 1.00 45.86  ? 357 ASP A OD2 1 
ATOM   2670 N N   . ILE A 1 358 ? 128.641 125.408 163.478 1.00 43.31  ? 358 ILE A N   1 
ATOM   2671 C CA  . ILE A 1 358 ? 128.875 125.381 162.028 1.00 43.31  ? 358 ILE A CA  1 
ATOM   2672 C C   . ILE A 1 358 ? 130.114 126.204 161.706 1.00 43.31  ? 358 ILE A C   1 
ATOM   2673 O O   . ILE A 1 358 ? 130.265 127.327 162.186 1.00 43.31  ? 358 ILE A O   1 
ATOM   2674 C CB  . ILE A 1 358 ? 127.685 125.949 161.223 1.00 43.31  ? 358 ILE A CB  1 
ATOM   2675 C CG1 . ILE A 1 358 ? 126.435 125.131 161.375 1.00 43.31  ? 358 ILE A CG1 1 
ATOM   2676 C CG2 . ILE A 1 358 ? 127.950 125.963 159.730 1.00 43.31  ? 358 ILE A CG2 1 
ATOM   2677 C CD1 . ILE A 1 358 ? 125.306 125.895 160.866 1.00 43.31  ? 358 ILE A CD1 1 
ATOM   2678 N N   . ALA A 1 359 ? 130.988 125.658 160.868 1.00 43.46  ? 359 ALA A N   1 
ATOM   2679 C CA  . ALA A 1 359 ? 132.019 126.433 160.197 1.00 43.46  ? 359 ALA A CA  1 
ATOM   2680 C C   . ALA A 1 359 ? 131.503 126.911 158.845 1.00 43.46  ? 359 ALA A C   1 
ATOM   2681 O O   . ALA A 1 359 ? 130.954 126.119 158.074 1.00 43.46  ? 359 ALA A O   1 
ATOM   2682 C CB  . ALA A 1 359 ? 133.282 125.600 160.008 1.00 43.46  ? 359 ALA A CB  1 
ATOM   2683 N N   . ILE A 1 360 ? 131.670 128.202 158.563 1.00 41.83  ? 360 ILE A N   1 
ATOM   2684 C CA  . ILE A 1 360 ? 131.359 128.782 157.261 1.00 41.83  ? 360 ILE A CA  1 
ATOM   2685 C C   . ILE A 1 360 ? 132.615 129.457 156.739 1.00 41.83  ? 360 ILE A C   1 
ATOM   2686 O O   . ILE A 1 360 ? 133.185 130.319 157.410 1.00 41.83  ? 360 ILE A O   1 
ATOM   2687 C CB  . ILE A 1 360 ? 130.193 129.783 157.329 1.00 41.83  ? 360 ILE A CB  1 
ATOM   2688 C CG1 . ILE A 1 360 ? 128.904 129.093 157.763 1.00 41.83  ? 360 ILE A CG1 1 
ATOM   2689 C CG2 . ILE A 1 360 ? 129.957 130.405 155.981 1.00 41.83  ? 360 ILE A CG2 1 
ATOM   2690 C CD1 . ILE A 1 360 ? 127.772 130.053 158.032 1.00 41.83  ? 360 ILE A CD1 1 
ATOM   2691 N N   . ALA A 1 361 ? 133.047 129.068 155.551 1.00 41.74  ? 361 ALA A N   1 
ATOM   2692 C CA  . ALA A 1 361 ? 134.305 129.539 155.001 1.00 41.74  ? 361 ALA A CA  1 
ATOM   2693 C C   . ALA A 1 361 ? 134.098 130.558 153.892 1.00 41.74  ? 361 ALA A C   1 
ATOM   2694 O O   . ALA A 1 361 ? 133.074 130.568 153.206 1.00 41.74  ? 361 ALA A O   1 
ATOM   2695 C CB  . ALA A 1 361 ? 135.133 128.385 154.448 1.00 41.74  ? 361 ALA A CB  1 
ATOM   2696 N N   . ALA A 1 362 ? 135.101 131.410 153.730 1.00 39.40  ? 362 ALA A N   1 
ATOM   2697 C CA  . ALA A 1 362 ? 135.212 132.321 152.596 1.00 39.40  ? 362 ALA A CA  1 
ATOM   2698 C C   . ALA A 1 362 ? 136.540 132.015 151.934 1.00 39.40  ? 362 ALA A C   1 
ATOM   2699 O O   . ALA A 1 362 ? 137.586 132.482 152.414 1.00 39.40  ? 362 ALA A O   1 
ATOM   2700 C CB  . ALA A 1 362 ? 135.156 133.774 153.048 1.00 39.40  ? 362 ALA A CB  1 
ATOM   2701 N N   . PRO A 1 363 ? 136.561 131.249 150.837 1.00 37.82  ? 363 PRO A N   1 
ATOM   2702 C CA  . PRO A 1 363 ? 137.823 130.681 150.350 1.00 37.82  ? 363 PRO A CA  1 
ATOM   2703 C C   . PRO A 1 363 ? 138.765 131.674 149.702 1.00 37.82  ? 363 PRO A C   1 
ATOM   2704 O O   . PRO A 1 363 ? 139.836 131.260 149.247 1.00 37.82  ? 363 PRO A O   1 
ATOM   2705 C CB  . PRO A 1 363 ? 137.360 129.644 149.330 1.00 37.82  ? 363 PRO A CB  1 
ATOM   2706 C CG  . PRO A 1 363 ? 135.991 129.365 149.680 1.00 37.82  ? 363 PRO A CG  1 
ATOM   2707 C CD  . PRO A 1 363 ? 135.420 130.634 150.156 1.00 37.82  ? 363 PRO A CD  1 
ATOM   2708 N N   . TYR A 1 364 ? 138.415 132.956 149.636 1.00 38.34  ? 364 TYR A N   1 
ATOM   2709 C CA  . TYR A 1 364 ? 139.271 133.963 149.033 1.00 38.34  ? 364 TYR A CA  1 
ATOM   2710 C C   . TYR A 1 364 ? 139.394 135.170 149.944 1.00 38.34  ? 364 TYR A C   1 
ATOM   2711 O O   . TYR A 1 364 ? 139.425 136.302 149.475 1.00 38.34  ? 364 TYR A O   1 
ATOM   2712 C CB  . TYR A 1 364 ? 138.735 134.381 147.667 1.00 38.34  ? 364 TYR A CB  1 
ATOM   2713 C CG  . TYR A 1 364 ? 138.504 133.215 146.750 1.00 38.34  ? 364 TYR A CG  1 
ATOM   2714 C CD1 . TYR A 1 364 ? 139.559 132.539 146.174 1.00 38.34  ? 364 TYR A CD1 1 
ATOM   2715 C CD2 . TYR A 1 364 ? 137.224 132.792 146.460 1.00 38.34  ? 364 TYR A CD2 1 
ATOM   2716 C CE1 . TYR A 1 364 ? 139.346 131.471 145.353 1.00 38.34  ? 364 TYR A CE1 1 
ATOM   2717 C CE2 . TYR A 1 364 ? 137.004 131.727 145.635 1.00 38.34  ? 364 TYR A CE2 1 
ATOM   2718 C CZ  . TYR A 1 364 ? 138.067 131.074 145.085 1.00 38.34  ? 364 TYR A CZ  1 
ATOM   2719 O OH  . TYR A 1 364 ? 137.842 130.010 144.258 1.00 38.34  ? 364 TYR A OH  1 
ATOM   2720 N N   . GLY A 1 365 ? 139.453 134.951 151.254 1.00 39.84  ? 365 GLY A N   1 
ATOM   2721 C CA  . GLY A 1 365 ? 139.501 136.025 152.215 1.00 39.84  ? 365 GLY A CA  1 
ATOM   2722 C C   . GLY A 1 365 ? 140.820 136.094 152.970 1.00 39.84  ? 365 GLY A C   1 
ATOM   2723 O O   . GLY A 1 365 ? 141.670 135.216 152.892 1.00 39.84  ? 365 GLY A O   1 
ATOM   2724 N N   . GLY A 1 366 ? 140.974 137.181 153.709 1.00 41.52  ? 366 GLY A N   1 
ATOM   2725 C CA  . GLY A 1 366 ? 142.134 137.328 154.556 1.00 41.52  ? 366 GLY A CA  1 
ATOM   2726 C C   . GLY A 1 366 ? 143.257 138.071 153.861 1.00 41.52  ? 366 GLY A C   1 
ATOM   2727 O O   . GLY A 1 366 ? 143.070 138.704 152.824 1.00 41.52  ? 366 GLY A O   1 
ATOM   2728 N N   . GLU A 1 367 ? 144.438 138.001 154.465 1.00 43.77  ? 367 GLU A N   1 
ATOM   2729 C CA  . GLU A 1 367 ? 145.618 138.574 153.844 1.00 43.77  ? 367 GLU A CA  1 
ATOM   2730 C C   . GLU A 1 367 ? 146.032 137.709 152.667 1.00 43.77  ? 367 GLU A C   1 
ATOM   2731 O O   . GLU A 1 367 ? 146.162 136.489 152.802 1.00 43.77  ? 367 GLU A O   1 
ATOM   2732 C CB  . GLU A 1 367 ? 146.753 138.679 154.858 1.00 43.77  ? 367 GLU A CB  1 
ATOM   2733 N N   . ASP A 1 368 ? 146.177 138.351 151.504 1.00 40.87  ? 368 ASP A N   1 
ATOM   2734 C CA  . ASP A 1 368 ? 146.514 137.739 150.216 1.00 40.87  ? 368 ASP A CA  1 
ATOM   2735 C C   . ASP A 1 368 ? 145.477 136.730 149.747 1.00 40.87  ? 368 ASP A C   1 
ATOM   2736 O O   . ASP A 1 368 ? 145.790 135.890 148.905 1.00 40.87  ? 368 ASP A O   1 
ATOM   2737 C CB  . ASP A 1 368 ? 147.908 137.102 150.232 1.00 40.87  ? 368 ASP A CB  1 
ATOM   2738 N N   . LYS A 1 369 ? 144.252 136.830 150.268 1.00 41.12  ? 369 LYS A N   1 
ATOM   2739 C CA  . LYS A 1 369 ? 143.070 136.092 149.801 1.00 41.12  ? 369 LYS A CA  1 
ATOM   2740 C C   . LYS A 1 369 ? 143.271 134.579 149.845 1.00 41.12  ? 369 LYS A C   1 
ATOM   2741 O O   . LYS A 1 369 ? 142.893 133.848 148.929 1.00 41.12  ? 369 LYS A O   1 
ATOM   2742 C CB  . LYS A 1 369 ? 142.656 136.546 148.401 1.00 41.12  ? 369 LYS A CB  1 
ATOM   2743 N N   . LYS A 1 370 ? 143.876 134.109 150.931 1.00 41.55  ? 370 LYS A N   1 
ATOM   2744 C CA  . LYS A 1 370 ? 144.194 132.696 151.040 1.00 41.55  ? 370 LYS A CA  1 
ATOM   2745 C C   . LYS A 1 370 ? 142.990 131.882 151.463 1.00 41.55  ? 370 LYS A C   1 
ATOM   2746 O O   . LYS A 1 370 ? 142.829 130.753 151.006 1.00 41.55  ? 370 LYS A O   1 
ATOM   2747 C CB  . LYS A 1 370 ? 145.344 132.509 152.016 1.00 41.55  ? 370 LYS A CB  1 
ATOM   2748 C CG  . LYS A 1 370 ? 146.610 133.164 151.543 1.00 41.55  ? 370 LYS A CG  1 
ATOM   2749 C CD  . LYS A 1 370 ? 147.707 133.024 152.545 1.00 41.55  ? 370 LYS A CD  1 
ATOM   2750 C CE  . LYS A 1 370 ? 148.937 133.758 152.092 1.00 41.55  ? 370 LYS A CE  1 
ATOM   2751 N NZ  . LYS A 1 370 ? 150.021 133.649 153.098 1.00 41.55  ? 370 LYS A NZ  1 
ATOM   2752 N N   . GLY A 1 371 ? 142.131 132.438 152.304 1.00 40.89  ? 371 GLY A N   1 
ATOM   2753 C CA  . GLY A 1 371 ? 140.916 131.766 152.706 1.00 40.89  ? 371 GLY A CA  1 
ATOM   2754 C C   . GLY A 1 371 ? 140.731 131.823 154.203 1.00 40.89  ? 371 GLY A C   1 
ATOM   2755 O O   . GLY A 1 371 ? 141.688 131.620 154.951 1.00 40.89  ? 371 GLY A O   1 
ATOM   2756 N N   . ILE A 1 372 ? 139.522 132.136 154.665 1.00 41.73  ? 372 ILE A N   1 
ATOM   2757 C CA  . ILE A 1 372 ? 139.236 132.149 156.088 1.00 41.73  ? 372 ILE A CA  1 
ATOM   2758 C C   . ILE A 1 372 ? 138.063 131.209 156.317 1.00 41.73  ? 372 ILE A C   1 
ATOM   2759 O O   . ILE A 1 372 ? 137.231 130.994 155.438 1.00 41.73  ? 372 ILE A O   1 
ATOM   2760 C CB  . ILE A 1 372 ? 138.896 133.551 156.635 1.00 41.73  ? 372 ILE A CB  1 
ATOM   2761 C CG1 . ILE A 1 372 ? 139.790 134.622 156.054 1.00 41.73  ? 372 ILE A CG1 1 
ATOM   2762 C CG2 . ILE A 1 372 ? 139.223 133.635 158.112 1.00 41.73  ? 372 ILE A CG2 1 
ATOM   2763 C CD1 . ILE A 1 372 ? 139.261 135.997 156.367 1.00 41.73  ? 372 ILE A CD1 1 
ATOM   2764 N N   . VAL A 1 373 ? 138.019 130.634 157.515 1.00 44.06  ? 373 VAL A N   1 
ATOM   2765 C CA  . VAL A 1 373 ? 136.901 129.838 157.996 1.00 44.06  ? 373 VAL A CA  1 
ATOM   2766 C C   . VAL A 1 373 ? 136.375 130.496 159.264 1.00 44.06  ? 373 VAL A C   1 
ATOM   2767 O O   . VAL A 1 373 ? 137.153 130.860 160.150 1.00 44.06  ? 373 VAL A O   1 
ATOM   2768 C CB  . VAL A 1 373 ? 137.330 128.383 158.256 1.00 44.06  ? 373 VAL A CB  1 
ATOM   2769 C CG1 . VAL A 1 373 ? 136.215 127.600 158.875 1.00 44.06  ? 373 VAL A CG1 1 
ATOM   2770 C CG2 . VAL A 1 373 ? 137.784 127.727 156.975 1.00 44.06  ? 373 VAL A CG2 1 
ATOM   2771 N N   . TYR A 1 374 ? 135.057 130.674 159.337 1.00 45.43  ? 374 TYR A N   1 
ATOM   2772 C CA  . TYR A 1 374 ? 134.394 131.365 160.434 1.00 45.43  ? 374 TYR A CA  1 
ATOM   2773 C C   . TYR A 1 374 ? 133.624 130.361 161.277 1.00 45.43  ? 374 TYR A C   1 
ATOM   2774 O O   . TYR A 1 374 ? 132.813 129.599 160.748 1.00 45.43  ? 374 TYR A O   1 
ATOM   2775 C CB  . TYR A 1 374 ? 133.450 132.434 159.889 1.00 45.43  ? 374 TYR A CB  1 
ATOM   2776 C CG  . TYR A 1 374 ? 134.160 133.581 159.224 1.00 45.43  ? 374 TYR A CG  1 
ATOM   2777 C CD1 . TYR A 1 374 ? 135.423 133.966 159.626 1.00 45.43  ? 374 TYR A CD1 1 
ATOM   2778 C CD2 . TYR A 1 374 ? 133.604 134.218 158.139 1.00 45.43  ? 374 TYR A CD2 1 
ATOM   2779 C CE1 . TYR A 1 374 ? 136.069 134.995 159.016 1.00 45.43  ? 374 TYR A CE1 1 
ATOM   2780 C CE2 . TYR A 1 374 ? 134.260 135.237 157.511 1.00 45.43  ? 374 TYR A CE2 1 
ATOM   2781 C CZ  . TYR A 1 374 ? 135.492 135.619 157.956 1.00 45.43  ? 374 TYR A CZ  1 
ATOM   2782 O OH  . TYR A 1 374 ? 136.150 136.645 157.335 1.00 45.43  ? 374 TYR A OH  1 
ATOM   2783 N N   . ILE A 1 375 ? 133.864 130.376 162.586 1.00 47.21  ? 375 ILE A N   1 
ATOM   2784 C CA  . ILE A 1 375 ? 133.291 129.405 163.510 1.00 47.21  ? 375 ILE A CA  1 
ATOM   2785 C C   . ILE A 1 375 ? 132.127 130.052 164.237 1.00 47.21  ? 375 ILE A C   1 
ATOM   2786 O O   . ILE A 1 375 ? 132.319 130.985 165.021 1.00 47.21  ? 375 ILE A O   1 
ATOM   2787 C CB  . ILE A 1 375 ? 134.343 128.899 164.505 1.00 47.21  ? 375 ILE A CB  1 
ATOM   2788 C CG1 . ILE A 1 375 ? 135.492 128.217 163.767 1.00 47.21  ? 375 ILE A CG1 1 
ATOM   2789 C CG2 . ILE A 1 375 ? 133.716 127.948 165.497 1.00 47.21  ? 375 ILE A CG2 1 
ATOM   2790 C CD1 . ILE A 1 375 ? 135.079 127.000 162.993 1.00 47.21  ? 375 ILE A CD1 1 
ATOM   2791 N N   . PHE A 1 376 ? 130.924 129.555 163.993 1.00 45.57  ? 376 PHE A N   1 
ATOM   2792 C CA  . PHE A 1 376 ? 129.711 130.106 164.575 1.00 45.57  ? 376 PHE A CA  1 
ATOM   2793 C C   . PHE A 1 376 ? 129.141 129.100 165.558 1.00 45.57  ? 376 PHE A C   1 
ATOM   2794 O O   . PHE A 1 376 ? 128.981 127.925 165.219 1.00 45.57  ? 376 PHE A O   1 
ATOM   2795 C CB  . PHE A 1 376 ? 128.682 130.441 163.496 1.00 45.57  ? 376 PHE A CB  1 
ATOM   2796 C CG  . PHE A 1 376 ? 129.101 131.553 162.589 1.00 45.57  ? 376 PHE A CG  1 
ATOM   2797 C CD1 . PHE A 1 376 ? 129.032 132.864 163.007 1.00 45.57  ? 376 PHE A CD1 1 
ATOM   2798 C CD2 . PHE A 1 376 ? 129.554 131.287 161.317 1.00 45.57  ? 376 PHE A CD2 1 
ATOM   2799 C CE1 . PHE A 1 376 ? 129.423 133.885 162.178 1.00 45.57  ? 376 PHE A CE1 1 
ATOM   2800 C CE2 . PHE A 1 376 ? 129.935 132.309 160.484 1.00 45.57  ? 376 PHE A CE2 1 
ATOM   2801 C CZ  . PHE A 1 376 ? 129.871 133.609 160.919 1.00 45.57  ? 376 PHE A CZ  1 
ATOM   2802 N N   . ASN A 1 377 ? 128.831 129.560 166.762 1.00 46.95  ? 377 ASN A N   1 
ATOM   2803 C CA  . ASN A 1 377 ? 128.314 128.696 167.805 1.00 46.95  ? 377 ASN A CA  1 
ATOM   2804 C C   . ASN A 1 377 ? 126.804 128.798 167.906 1.00 46.95  ? 377 ASN A C   1 
ATOM   2805 O O   . ASN A 1 377 ? 126.202 129.800 167.527 1.00 46.95  ? 377 ASN A O   1 
ATOM   2806 C CB  . ASN A 1 377 ? 128.931 129.039 169.150 1.00 46.95  ? 377 ASN A CB  1 
ATOM   2807 C CG  . ASN A 1 377 ? 130.389 128.757 169.186 1.00 46.95  ? 377 ASN A CG  1 
ATOM   2808 O OD1 . ASN A 1 377 ? 131.197 129.654 169.332 1.00 46.95  ? 377 ASN A OD1 1 
ATOM   2809 N ND2 . ASN A 1 377 ? 130.746 127.496 169.042 1.00 46.95  ? 377 ASN A ND2 1 
ATOM   2810 N N   . GLY A 1 378 ? 126.202 127.755 168.434 1.00 47.24  ? 378 GLY A N   1 
ATOM   2811 C CA  . GLY A 1 378 ? 124.774 127.754 168.640 1.00 47.24  ? 378 GLY A CA  1 
ATOM   2812 C C   . GLY A 1 378 ? 124.385 128.361 169.972 1.00 47.24  ? 378 GLY A C   1 
ATOM   2813 O O   . GLY A 1 378 ? 125.177 128.452 170.906 1.00 47.24  ? 378 GLY A O   1 
ATOM   2814 N N   . ARG A 1 379 ? 123.130 128.787 170.040 1.00 46.84  ? 379 ARG A N   1 
ATOM   2815 C CA  . ARG A 1 379 ? 122.525 129.278 171.264 1.00 46.84  ? 379 ARG A CA  1 
ATOM   2816 C C   . ARG A 1 379 ? 121.104 128.751 171.283 1.00 46.84  ? 379 ARG A C   1 
ATOM   2817 O O   . ARG A 1 379 ? 120.658 128.119 170.328 1.00 46.84  ? 379 ARG A O   1 
ATOM   2818 C CB  . ARG A 1 379 ? 122.558 130.802 171.336 1.00 46.84  ? 379 ARG A CB  1 
ATOM   2819 N N   . SER A 1 380 ? 120.400 128.996 172.383 1.00 48.33  ? 380 SER A N   1 
ATOM   2820 C CA  . SER A 1 380 ? 119.065 128.427 172.528 1.00 48.33  ? 380 SER A CA  1 
ATOM   2821 C C   . SER A 1 380 ? 118.057 129.080 171.602 1.00 48.33  ? 380 SER A C   1 
ATOM   2822 O O   . SER A 1 380 ? 117.065 128.446 171.233 1.00 48.33  ? 380 SER A O   1 
ATOM   2823 C CB  . SER A 1 380 ? 118.590 128.551 173.975 1.00 48.33  ? 380 SER A CB  1 
ATOM   2824 O OG  . SER A 1 380 ? 118.389 129.908 174.331 1.00 48.33  ? 380 SER A OG  1 
ATOM   2825 N N   . THR A 1 381 ? 118.294 130.328 171.217 1.00 47.93  ? 381 THR A N   1 
ATOM   2826 C CA  . THR A 1 381 ? 117.437 131.037 170.282 1.00 47.93  ? 381 THR A CA  1 
ATOM   2827 C C   . THR A 1 381 ? 117.726 130.685 168.833 1.00 47.93  ? 381 THR A C   1 
ATOM   2828 O O   . THR A 1 381 ? 116.904 130.989 167.965 1.00 47.93  ? 381 THR A O   1 
ATOM   2829 C CB  . THR A 1 381 ? 117.593 132.549 170.471 1.00 47.93  ? 381 THR A CB  1 
ATOM   2830 N N   . GLY A 1 382 ? 118.857 130.048 168.555 1.00 46.33  ? 382 GLY A N   1 
ATOM   2831 C CA  . GLY A 1 382 ? 119.259 129.778 167.193 1.00 46.33  ? 382 GLY A CA  1 
ATOM   2832 C C   . GLY A 1 382 ? 120.758 129.799 167.028 1.00 46.33  ? 382 GLY A C   1 
ATOM   2833 O O   . GLY A 1 382 ? 121.469 129.006 167.641 1.00 46.33  ? 382 GLY A O   1 
ATOM   2834 N N   . LEU A 1 383 ? 121.245 130.695 166.184 1.00 46.83  ? 383 LEU A N   1 
ATOM   2835 C CA  . LEU A 1 383 ? 122.669 130.823 165.931 1.00 46.83  ? 383 LEU A CA  1 
ATOM   2836 C C   . LEU A 1 383 ? 123.195 132.118 166.524 1.00 46.83  ? 383 LEU A C   1 
ATOM   2837 O O   . LEU A 1 383 ? 122.491 133.126 166.582 1.00 46.83  ? 383 LEU A O   1 
ATOM   2838 C CB  . LEU A 1 383 ? 122.933 130.791 164.426 1.00 46.83  ? 383 LEU A CB  1 
ATOM   2839 C CG  . LEU A 1 383 ? 124.345 130.860 163.858 1.00 46.83  ? 383 LEU A CG  1 
ATOM   2840 C CD1 . LEU A 1 383 ? 125.145 129.674 164.305 1.00 46.83  ? 383 LEU A CD1 1 
ATOM   2841 C CD2 . LEU A 1 383 ? 124.282 130.918 162.352 1.00 46.83  ? 383 LEU A CD2 1 
ATOM   2842 N N   . ASN A 1 384 ? 124.438 132.083 166.983 1.00 48.03  ? 384 ASN A N   1 
ATOM   2843 C CA  . ASN A 1 384 ? 125.145 133.294 167.359 1.00 48.03  ? 384 ASN A CA  1 
ATOM   2844 C C   . ASN A 1 384 ? 125.730 133.905 166.098 1.00 48.03  ? 384 ASN A C   1 
ATOM   2845 O O   . ASN A 1 384 ? 126.500 133.250 165.393 1.00 48.03  ? 384 ASN A O   1 
ATOM   2846 C CB  . ASN A 1 384 ? 126.246 132.986 168.370 1.00 48.03  ? 384 ASN A CB  1 
ATOM   2847 C CG  . ASN A 1 384 ? 126.807 134.226 169.025 1.00 48.03  ? 384 ASN A CG  1 
ATOM   2848 O OD1 . ASN A 1 384 ? 126.363 135.341 168.765 1.00 48.03  ? 384 ASN A OD1 1 
ATOM   2849 N ND2 . ASN A 1 384 ? 127.801 134.037 169.878 1.00 48.03  ? 384 ASN A ND2 1 
ATOM   2850 N N   . ALA A 1 385 ? 125.368 135.155 165.816 1.00 46.69  ? 385 ALA A N   1 
ATOM   2851 C CA  . ALA A 1 385 ? 125.720 135.748 164.531 1.00 46.69  ? 385 ALA A CA  1 
ATOM   2852 C C   . ALA A 1 385 ? 127.170 136.210 164.483 1.00 46.69  ? 385 ALA A C   1 
ATOM   2853 O O   . ALA A 1 385 ? 127.733 136.352 163.395 1.00 46.69  ? 385 ALA A O   1 
ATOM   2854 C CB  . ALA A 1 385 ? 124.789 136.914 164.218 1.00 46.69  ? 385 ALA A CB  1 
ATOM   2855 N N   . VAL A 1 386 ? 127.781 136.469 165.630 1.00 47.26  ? 386 VAL A N   1 
ATOM   2856 C CA  . VAL A 1 386 ? 129.184 136.863 165.675 1.00 47.26  ? 386 VAL A CA  1 
ATOM   2857 C C   . VAL A 1 386 ? 130.001 135.579 165.648 1.00 47.26  ? 386 VAL A C   1 
ATOM   2858 O O   . VAL A 1 386 ? 129.655 134.625 166.357 1.00 47.26  ? 386 VAL A O   1 
ATOM   2859 C CB  . VAL A 1 386 ? 129.485 137.711 166.922 1.00 47.26  ? 386 VAL A CB  1 
ATOM   2860 C CG1 . VAL A 1 386 ? 130.956 138.061 167.013 1.00 47.26  ? 386 VAL A CG1 1 
ATOM   2861 C CG2 . VAL A 1 386 ? 128.646 138.969 166.919 1.00 47.26  ? 386 VAL A CG2 1 
ATOM   2862 N N   . PRO A 1 387 ? 131.051 135.483 164.837 1.00 47.28  ? 387 PRO A N   1 
ATOM   2863 C CA  . PRO A 1 387 ? 131.878 134.278 164.861 1.00 47.28  ? 387 PRO A CA  1 
ATOM   2864 C C   . PRO A 1 387 ? 132.727 134.209 166.115 1.00 47.28  ? 387 PRO A C   1 
ATOM   2865 O O   . PRO A 1 387 ? 132.959 135.211 166.792 1.00 47.28  ? 387 PRO A O   1 
ATOM   2866 C CB  . PRO A 1 387 ? 132.745 134.423 163.611 1.00 47.28  ? 387 PRO A CB  1 
ATOM   2867 C CG  . PRO A 1 387 ? 132.806 135.871 163.374 1.00 47.28  ? 387 PRO A CG  1 
ATOM   2868 C CD  . PRO A 1 387 ? 131.483 136.412 163.781 1.00 47.28  ? 387 PRO A CD  1 
ATOM   2869 N N   . SER A 1 388 ? 133.187 132.997 166.425 1.00 49.54  ? 388 SER A N   1 
ATOM   2870 C CA  . SER A 1 388 ? 134.014 132.789 167.608 1.00 49.54  ? 388 SER A CA  1 
ATOM   2871 C C   . SER A 1 388 ? 135.495 132.755 167.272 1.00 49.54  ? 388 SER A C   1 
ATOM   2872 O O   . SER A 1 388 ? 136.323 133.224 168.055 1.00 49.54  ? 388 SER A O   1 
ATOM   2873 C CB  . SER A 1 388 ? 133.624 131.492 168.292 1.00 49.54  ? 388 SER A CB  1 
ATOM   2874 O OG  . SER A 1 388 ? 132.283 131.546 168.718 1.00 49.54  ? 388 SER A OG  1 
ATOM   2875 N N   . GLN A 1 389 ? 135.849 132.189 166.126 1.00 50.46  ? 389 GLN A N   1 
ATOM   2876 C CA  . GLN A 1 389 ? 137.243 132.030 165.763 1.00 50.46  ? 389 GLN A CA  1 
ATOM   2877 C C   . GLN A 1 389 ? 137.354 132.096 164.250 1.00 50.46  ? 389 GLN A C   1 
ATOM   2878 O O   . GLN A 1 389 ? 136.476 131.627 163.526 1.00 50.46  ? 389 GLN A O   1 
ATOM   2879 C CB  . GLN A 1 389 ? 137.800 130.704 166.289 1.00 50.46  ? 389 GLN A CB  1 
ATOM   2880 C CG  . GLN A 1 389 ? 139.298 130.524 166.121 1.00 50.46  ? 389 GLN A CG  1 
ATOM   2881 C CD  . GLN A 1 389 ? 139.770 129.186 166.605 1.00 50.46  ? 389 GLN A CD  1 
ATOM   2882 O OE1 . GLN A 1 389 ? 138.975 128.341 166.998 1.00 50.46  ? 389 GLN A OE1 1 
ATOM   2883 N NE2 . GLN A 1 389 ? 141.072 128.986 166.590 1.00 50.46  ? 389 GLN A NE2 1 
ATOM   2884 N N   . ILE A 1 390 ? 138.436 132.704 163.781 1.00 48.95  ? 390 ILE A N   1 
ATOM   2885 C CA  . ILE A 1 390 ? 138.772 132.729 162.369 1.00 48.95  ? 390 ILE A CA  1 
ATOM   2886 C C   . ILE A 1 390 ? 139.915 131.754 162.139 1.00 48.95  ? 390 ILE A C   1 
ATOM   2887 O O   . ILE A 1 390 ? 140.732 131.512 163.033 1.00 48.95  ? 390 ILE A O   1 
ATOM   2888 C CB  . ILE A 1 390 ? 139.133 134.148 161.886 1.00 48.95  ? 390 ILE A CB  1 
ATOM   2889 C CG1 . ILE A 1 390 ? 140.371 134.684 162.601 1.00 48.95  ? 390 ILE A CG1 1 
ATOM   2890 C CG2 . ILE A 1 390 ? 137.974 135.082 162.123 1.00 48.95  ? 390 ILE A CG2 1 
ATOM   2891 C CD1 . ILE A 1 390 ? 140.917 135.958 162.004 1.00 48.95  ? 390 ILE A CD1 1 
ATOM   2892 N N   . LEU A 1 391 ? 139.945 131.161 160.953 1.00 47.13  ? 391 LEU A N   1 
ATOM   2893 C CA  . LEU A 1 391 ? 140.947 130.171 160.593 1.00 47.13  ? 391 LEU A CA  1 
ATOM   2894 C C   . LEU A 1 391 ? 141.613 130.617 159.308 1.00 47.13  ? 391 LEU A C   1 
ATOM   2895 O O   . LEU A 1 391 ? 141.079 130.390 158.223 1.00 47.13  ? 391 LEU A O   1 
ATOM   2896 C CB  . LEU A 1 391 ? 140.330 128.785 160.421 1.00 47.13  ? 391 LEU A CB  1 
ATOM   2897 C CG  . LEU A 1 391 ? 140.106 127.868 161.620 1.00 47.13  ? 391 LEU A CG  1 
ATOM   2898 C CD1 . LEU A 1 391 ? 138.999 128.350 162.508 1.00 47.13  ? 391 LEU A CD1 1 
ATOM   2899 C CD2 . LEU A 1 391 ? 139.768 126.504 161.103 1.00 47.13  ? 391 LEU A CD2 1 
ATOM   2900 N N   . GLU A 1 392 ? 142.774 131.237 159.433 1.00 50.00  ? 392 GLU A N   1 
ATOM   2901 C CA  . GLU A 1 392 ? 143.490 131.816 158.309 1.00 50.00  ? 392 GLU A CA  1 
ATOM   2902 C C   . GLU A 1 392 ? 144.405 130.760 157.710 1.00 50.00  ? 392 GLU A C   1 
ATOM   2903 O O   . GLU A 1 392 ? 145.250 130.200 158.416 1.00 50.00  ? 392 GLU A O   1 
ATOM   2904 C CB  . GLU A 1 392 ? 144.301 133.027 158.760 1.00 50.00  ? 392 GLU A CB  1 
ATOM   2905 C CG  . GLU A 1 392 ? 143.464 134.170 159.285 1.00 50.00  ? 392 GLU A CG  1 
ATOM   2906 C CD  . GLU A 1 392 ? 144.312 135.331 159.768 1.00 50.00  ? 392 GLU A CD  1 
ATOM   2907 O OE1 . GLU A 1 392 ? 145.552 135.193 159.788 1.00 50.00  ? 392 GLU A OE1 1 
ATOM   2908 O OE2 . GLU A 1 392 ? 143.740 136.379 160.134 1.00 50.00  ? 392 GLU A OE2 1 
ATOM   2909 N N   . GLY A 1 393 ? 144.237 130.487 156.420 1.00 46.22  ? 393 GLY A N   1 
ATOM   2910 C CA  . GLY A 1 393 ? 145.142 129.581 155.744 1.00 46.22  ? 393 GLY A CA  1 
ATOM   2911 C C   . GLY A 1 393 ? 146.504 130.222 155.572 1.00 46.22  ? 393 GLY A C   1 
ATOM   2912 O O   . GLY A 1 393 ? 146.620 131.398 155.234 1.00 46.22  ? 393 GLY A O   1 
ATOM   2913 N N   . GLN A 1 394 ? 147.549 129.439 155.830 1.00 49.65  ? 394 GLN A N   1 
ATOM   2914 C CA  . GLN A 1 394 ? 148.915 129.945 155.844 1.00 49.65  ? 394 GLN A CA  1 
ATOM   2915 C C   . GLN A 1 394 ? 149.696 129.561 154.601 1.00 49.65  ? 394 GLN A C   1 
ATOM   2916 O O   . GLN A 1 394 ? 150.926 129.632 154.607 1.00 49.65  ? 394 GLN A O   1 
ATOM   2917 C CB  . GLN A 1 394 ? 149.659 129.452 157.081 1.00 49.65  ? 394 GLN A CB  1 
ATOM   2918 C CG  . GLN A 1 394 ? 149.158 130.021 158.391 1.00 49.65  ? 394 GLN A CG  1 
ATOM   2919 C CD  . GLN A 1 394 ? 149.323 131.519 158.463 1.00 49.65  ? 394 GLN A CD  1 
ATOM   2920 O OE1 . GLN A 1 394 ? 148.344 132.264 158.458 1.00 49.65  ? 394 GLN A OE1 1 
ATOM   2921 N NE2 . GLN A 1 394 ? 150.568 131.972 158.516 1.00 49.65  ? 394 GLN A NE2 1 
ATOM   2922 N N   . TRP A 1 395 ? 149.018 129.159 153.536 1.00 47.58  ? 395 TRP A N   1 
ATOM   2923 C CA  . TRP A 1 395 ? 149.674 128.692 152.324 1.00 47.58  ? 395 TRP A CA  1 
ATOM   2924 C C   . TRP A 1 395 ? 149.516 129.734 151.233 1.00 47.58  ? 395 TRP A C   1 
ATOM   2925 O O   . TRP A 1 395 ? 148.392 130.091 150.873 1.00 47.58  ? 395 TRP A O   1 
ATOM   2926 C CB  . TRP A 1 395 ? 149.093 127.360 151.865 1.00 47.58  ? 395 TRP A CB  1 
ATOM   2927 C CG  . TRP A 1 395 ? 149.344 126.254 152.815 1.00 47.58  ? 395 TRP A CG  1 
ATOM   2928 C CD1 . TRP A 1 395 ? 150.472 125.513 152.919 1.00 47.58  ? 395 TRP A CD1 1 
ATOM   2929 C CD2 . TRP A 1 395 ? 148.430 125.733 153.772 1.00 47.58  ? 395 TRP A CD2 1 
ATOM   2930 N NE1 . TRP A 1 395 ? 150.330 124.575 153.899 1.00 47.58  ? 395 TRP A NE1 1 
ATOM   2931 C CE2 . TRP A 1 395 ? 149.078 124.689 154.438 1.00 47.58  ? 395 TRP A CE2 1 
ATOM   2932 C CE3 . TRP A 1 395 ? 147.126 126.060 154.139 1.00 47.58  ? 395 TRP A CE3 1 
ATOM   2933 C CZ2 . TRP A 1 395 ? 148.472 123.962 155.446 1.00 47.58  ? 395 TRP A CZ2 1 
ATOM   2934 C CZ3 . TRP A 1 395 ? 146.525 125.342 155.142 1.00 47.58  ? 395 TRP A CZ3 1 
ATOM   2935 C CH2 . TRP A 1 395 ? 147.198 124.304 155.786 1.00 47.58  ? 395 TRP A CH2 1 
ATOM   2936 N N   . ALA A 1 396 ? 150.636 130.208 150.705 1.00 45.63  ? 396 ALA A N   1 
ATOM   2937 C CA  . ALA A 1 396 ? 150.595 131.184 149.632 1.00 45.63  ? 396 ALA A CA  1 
ATOM   2938 C C   . ALA A 1 396 ? 150.213 130.513 148.324 1.00 45.63  ? 396 ALA A C   1 
ATOM   2939 O O   . ALA A 1 396 ? 150.431 129.317 148.129 1.00 45.63  ? 396 ALA A O   1 
ATOM   2940 C CB  . ALA A 1 396 ? 151.946 131.876 149.485 1.00 45.63  ? 396 ALA A CB  1 
ATOM   2941 N N   . ALA A 1 397 ? 149.630 131.298 147.427 1.00 44.60  ? 397 ALA A N   1 
ATOM   2942 C CA  . ALA A 1 397 ? 149.233 130.783 146.130 1.00 44.60  ? 397 ALA A CA  1 
ATOM   2943 C C   . ALA A 1 397 ? 150.458 130.521 145.270 1.00 44.60  ? 397 ALA A C   1 
ATOM   2944 O O   . ALA A 1 397 ? 151.505 131.148 145.436 1.00 44.60  ? 397 ALA A O   1 
ATOM   2945 C CB  . ALA A 1 397 ? 148.308 131.766 145.425 1.00 44.60  ? 397 ALA A CB  1 
ATOM   2946 N N   . ARG A 1 398 ? 150.324 129.569 144.351 1.00 45.31  ? 398 ARG A N   1 
ATOM   2947 C CA  . ARG A 1 398 ? 151.385 129.266 143.404 1.00 45.31  ? 398 ARG A CA  1 
ATOM   2948 C C   . ARG A 1 398 ? 150.968 129.571 141.972 1.00 45.31  ? 398 ARG A C   1 
ATOM   2949 O O   . ARG A 1 398 ? 151.607 130.381 141.300 1.00 45.31  ? 398 ARG A O   1 
ATOM   2950 C CB  . ARG A 1 398 ? 151.805 127.799 143.539 1.00 45.31  ? 398 ARG A CB  1 
ATOM   2951 N N   . SER A 1 399 ? 149.900 128.953 141.491 1.00 43.42  ? 399 SER A N   1 
ATOM   2952 C CA  . SER A 1 399 ? 149.429 129.194 140.143 1.00 43.42  ? 399 SER A CA  1 
ATOM   2953 C C   . SER A 1 399 ? 147.934 129.409 140.073 1.00 43.42  ? 399 SER A C   1 
ATOM   2954 O O   . SER A 1 399 ? 147.438 129.861 139.038 1.00 43.42  ? 399 SER A O   1 
ATOM   2955 C CB  . SER A 1 399 ? 149.807 128.029 139.225 1.00 43.42  ? 399 SER A CB  1 
ATOM   2956 O OG  . SER A 1 399 ? 149.304 128.239 137.920 1.00 43.42  ? 399 SER A OG  1 
ATOM   2957 N N   . MET A 1 400 ? 147.208 129.089 141.130 1.00 41.46  ? 400 MET A N   1 
ATOM   2958 C CA  . MET A 1 400 ? 145.796 129.376 141.300 1.00 41.46  ? 400 MET A CA  1 
ATOM   2959 C C   . MET A 1 400 ? 145.628 129.785 142.754 1.00 41.46  ? 400 MET A C   1 
ATOM   2960 O O   . MET A 1 400 ? 146.585 129.677 143.528 1.00 41.46  ? 400 MET A O   1 
ATOM   2961 C CB  . MET A 1 400 ? 144.956 128.146 140.932 1.00 41.46  ? 400 MET A CB  1 
ATOM   2962 C CG  . MET A 1 400 ? 145.163 126.968 141.820 1.00 41.46  ? 400 MET A CG  1 
ATOM   2963 S SD  . MET A 1 400 ? 143.993 125.690 141.401 1.00 41.46  ? 400 MET A SD  1 
ATOM   2964 C CE  . MET A 1 400 ? 142.496 126.424 142.029 1.00 41.46  ? 400 MET A CE  1 
ATOM   2965 N N   . PRO A 1 401 ? 144.470 130.328 143.147 1.00 40.34  ? 401 PRO A N   1 
ATOM   2966 C CA  . PRO A 1 401 ? 144.255 130.631 144.569 1.00 40.34  ? 401 PRO A CA  1 
ATOM   2967 C C   . PRO A 1 401 ? 144.292 129.379 145.427 1.00 40.34  ? 401 PRO A C   1 
ATOM   2968 O O   . PRO A 1 401 ? 143.941 128.288 144.954 1.00 40.34  ? 401 PRO A O   1 
ATOM   2969 C CB  . PRO A 1 401 ? 142.865 131.267 144.578 1.00 40.34  ? 401 PRO A CB  1 
ATOM   2970 C CG  . PRO A 1 401 ? 142.756 131.883 143.293 1.00 40.34  ? 401 PRO A CG  1 
ATOM   2971 C CD  . PRO A 1 401 ? 143.435 130.990 142.331 1.00 40.34  ? 401 PRO A CD  1 
ATOM   2972 N N   . PRO A 1 402 ? 144.733 129.492 146.687 1.00 39.16  ? 402 PRO A N   1 
ATOM   2973 C CA  . PRO A 1 402 ? 144.878 128.299 147.523 1.00 39.16  ? 402 PRO A CA  1 
ATOM   2974 C C   . PRO A 1 402 ? 143.570 127.657 147.905 1.00 39.16  ? 402 PRO A C   1 
ATOM   2975 O O   . PRO A 1 402 ? 143.581 126.476 148.265 1.00 39.16  ? 402 PRO A O   1 
ATOM   2976 C CB  . PRO A 1 402 ? 145.607 128.832 148.753 1.00 39.16  ? 402 PRO A CB  1 
ATOM   2977 C CG  . PRO A 1 402 ? 146.246 130.038 148.310 1.00 39.16  ? 402 PRO A CG  1 
ATOM   2978 C CD  . PRO A 1 402 ? 145.328 130.657 147.343 1.00 39.16  ? 402 PRO A CD  1 
ATOM   2979 N N   . SER A 1 403 ? 142.464 128.405 147.861 1.00 39.31  ? 403 SER A N   1 
ATOM   2980 C CA  . SER A 1 403 ? 141.099 127.892 147.999 1.00 39.31  ? 403 SER A CA  1 
ATOM   2981 C C   . SER A 1 403 ? 140.871 127.211 149.342 1.00 39.31  ? 403 SER A C   1 
ATOM   2982 O O   . SER A 1 403 ? 140.245 126.157 149.419 1.00 39.31  ? 403 SER A O   1 
ATOM   2983 C CB  . SER A 1 403 ? 140.752 126.955 146.850 1.00 39.31  ? 403 SER A CB  1 
ATOM   2984 O OG  . SER A 1 403 ? 140.817 127.639 145.615 1.00 39.31  ? 403 SER A OG  1 
ATOM   2985 N N   . PHE A 1 404 ? 141.388 127.827 150.402 1.00 41.05  ? 404 PHE A N   1 
ATOM   2986 C CA  . PHE A 1 404 ? 141.309 127.282 151.751 1.00 41.05  ? 404 PHE A CA  1 
ATOM   2987 C C   . PHE A 1 404 ? 139.889 127.372 152.263 1.00 41.05  ? 404 PHE A C   1 
ATOM   2988 O O   . PHE A 1 404 ? 139.356 128.466 152.442 1.00 41.05  ? 404 PHE A O   1 
ATOM   2989 C CB  . PHE A 1 404 ? 142.247 128.047 152.672 1.00 41.05  ? 404 PHE A CB  1 
ATOM   2990 C CG  . PHE A 1 404 ? 142.232 127.581 154.094 1.00 41.05  ? 404 PHE A CG  1 
ATOM   2991 C CD1 . PHE A 1 404 ? 142.944 126.469 154.473 1.00 41.05  ? 404 PHE A CD1 1 
ATOM   2992 C CD2 . PHE A 1 404 ? 141.521 128.272 155.057 1.00 41.05  ? 404 PHE A CD2 1 
ATOM   2993 C CE1 . PHE A 1 404 ? 142.940 126.053 155.774 1.00 41.05  ? 404 PHE A CE1 1 
ATOM   2994 C CE2 . PHE A 1 404 ? 141.504 127.846 156.353 1.00 41.05  ? 404 PHE A CE2 1 
ATOM   2995 C CZ  . PHE A 1 404 ? 142.216 126.741 156.714 1.00 41.05  ? 404 PHE A CZ  1 
ATOM   2996 N N   . GLY A 1 405 ? 139.284 126.232 152.522 1.00 40.97  ? 405 GLY A N   1 
ATOM   2997 C CA  . GLY A 1 405 ? 137.918 126.205 152.965 1.00 40.97  ? 405 GLY A CA  1 
ATOM   2998 C C   . GLY A 1 405 ? 136.920 125.998 151.866 1.00 40.97  ? 405 GLY A C   1 
ATOM   2999 O O   . GLY A 1 405 ? 135.723 126.173 152.104 1.00 40.97  ? 405 GLY A O   1 
ATOM   3000 N N   . TYR A 1 406 ? 137.368 125.637 150.668 1.00 39.44  ? 406 TYR A N   1 
ATOM   3001 C CA  . TYR A 1 406 ? 136.426 125.334 149.604 1.00 39.44  ? 406 TYR A CA  1 
ATOM   3002 C C   . TYR A 1 406 ? 135.691 124.040 149.894 1.00 39.44  ? 406 TYR A C   1 
ATOM   3003 O O   . TYR A 1 406 ? 134.531 123.883 149.511 1.00 39.44  ? 406 TYR A O   1 
ATOM   3004 C CB  . TYR A 1 406 ? 137.156 125.263 148.269 1.00 39.44  ? 406 TYR A CB  1 
ATOM   3005 C CG  . TYR A 1 406 ? 136.238 125.145 147.079 1.00 39.44  ? 406 TYR A CG  1 
ATOM   3006 C CD1 . TYR A 1 406 ? 135.544 126.243 146.615 1.00 39.44  ? 406 TYR A CD1 1 
ATOM   3007 C CD2 . TYR A 1 406 ? 136.067 123.939 146.427 1.00 39.44  ? 406 TYR A CD2 1 
ATOM   3008 C CE1 . TYR A 1 406 ? 134.713 126.139 145.542 1.00 39.44  ? 406 TYR A CE1 1 
ATOM   3009 C CE2 . TYR A 1 406 ? 135.238 123.835 145.363 1.00 39.44  ? 406 TYR A CE2 1 
ATOM   3010 C CZ  . TYR A 1 406 ? 134.566 124.933 144.922 1.00 39.44  ? 406 TYR A CZ  1 
ATOM   3011 O OH  . TYR A 1 406 ? 133.734 124.837 143.841 1.00 39.44  ? 406 TYR A OH  1 
ATOM   3012 N N   . SER A 1 407 ? 136.340 123.120 150.593 1.00 41.55  ? 407 SER A N   1 
ATOM   3013 C CA  . SER A 1 407 ? 135.702 121.935 151.132 1.00 41.55  ? 407 SER A CA  1 
ATOM   3014 C C   . SER A 1 407 ? 136.134 121.762 152.575 1.00 41.55  ? 407 SER A C   1 
ATOM   3015 O O   . SER A 1 407 ? 137.313 121.903 152.897 1.00 41.55  ? 407 SER A O   1 
ATOM   3016 C CB  . SER A 1 407 ? 136.075 120.693 150.342 1.00 41.55  ? 407 SER A CB  1 
ATOM   3017 O OG  . SER A 1 407 ? 137.446 120.405 150.513 1.00 41.55  ? 407 SER A OG  1 
ATOM   3018 N N   . MET A 1 408 ? 135.175 121.468 153.441 1.00 43.92  ? 408 MET A N   1 
ATOM   3019 C CA  . MET A 1 408 ? 135.437 121.208 154.844 1.00 43.92  ? 408 MET A CA  1 
ATOM   3020 C C   . MET A 1 408 ? 134.563 120.052 155.285 1.00 43.92  ? 408 MET A C   1 
ATOM   3021 O O   . MET A 1 408 ? 133.578 119.716 154.629 1.00 43.92  ? 408 MET A O   1 
ATOM   3022 C CB  . MET A 1 408 ? 135.123 122.412 155.727 1.00 43.92  ? 408 MET A CB  1 
ATOM   3023 C CG  . MET A 1 408 ? 135.948 123.639 155.482 1.00 43.92  ? 408 MET A CG  1 
ATOM   3024 S SD  . MET A 1 408 ? 135.388 124.913 156.594 1.00 43.92  ? 408 MET A SD  1 
ATOM   3025 C CE  . MET A 1 408 ? 133.783 125.249 155.892 1.00 43.92  ? 408 MET A CE  1 
ATOM   3026 N N   . LYS A 1 409 ? 134.912 119.467 156.425 1.00 45.31  ? 409 LYS A N   1 
ATOM   3027 C CA  . LYS A 1 409 ? 134.099 118.410 157.010 1.00 45.31  ? 409 LYS A CA  1 
ATOM   3028 C C   . LYS A 1 409 ? 134.396 118.334 158.498 1.00 45.31  ? 409 LYS A C   1 
ATOM   3029 O O   . LYS A 1 409 ? 135.560 118.317 158.896 1.00 45.31  ? 409 LYS A O   1 
ATOM   3030 C CB  . LYS A 1 409 ? 134.370 117.068 156.326 1.00 45.31  ? 409 LYS A CB  1 
ATOM   3031 C CG  . LYS A 1 409 ? 133.518 115.956 156.828 1.00 45.31  ? 409 LYS A CG  1 
ATOM   3032 C CD  . LYS A 1 409 ? 132.097 116.239 156.521 1.00 45.31  ? 409 LYS A CD  1 
ATOM   3033 C CE  . LYS A 1 409 ? 131.229 115.113 156.996 1.00 45.31  ? 409 LYS A CE  1 
ATOM   3034 N NZ  . LYS A 1 409 ? 129.792 115.469 156.898 1.00 45.31  ? 409 LYS A NZ  1 
ATOM   3035 N N   . GLY A 1 410 ? 133.349 118.301 159.313 1.00 47.98  ? 410 GLY A N   1 
ATOM   3036 C CA  . GLY A 1 410 ? 133.529 118.208 160.747 1.00 47.98  ? 410 GLY A CA  1 
ATOM   3037 C C   . GLY A 1 410 ? 132.721 117.090 161.366 1.00 47.98  ? 410 GLY A C   1 
ATOM   3038 O O   . GLY A 1 410 ? 132.493 116.062 160.725 1.00 47.98  ? 410 GLY A O   1 
ATOM   3039 N N   . ALA A 1 411 ? 132.305 117.282 162.618 1.00 49.99  ? 411 ALA A N   1 
ATOM   3040 C CA  . ALA A 1 411 ? 131.434 116.404 163.398 1.00 49.99  ? 411 ALA A CA  1 
ATOM   3041 C C   . ALA A 1 411 ? 131.990 115.001 163.598 1.00 49.99  ? 411 ALA A C   1 
ATOM   3042 O O   . ALA A 1 411 ? 131.212 114.062 163.793 1.00 49.99  ? 411 ALA A O   1 
ATOM   3043 C CB  . ALA A 1 411 ? 130.029 116.303 162.793 1.00 49.99  ? 411 ALA A CB  1 
ATOM   3044 N N   . THR A 1 412 ? 133.309 114.828 163.562 1.00 51.18  ? 412 THR A N   1 
ATOM   3045 C CA  . THR A 1 412 ? 133.950 113.556 163.854 1.00 51.18  ? 412 THR A CA  1 
ATOM   3046 C C   . THR A 1 412 ? 135.216 113.826 164.639 1.00 51.18  ? 412 THR A C   1 
ATOM   3047 O O   . THR A 1 412 ? 136.086 114.564 164.174 1.00 51.18  ? 412 THR A O   1 
ATOM   3048 C CB  . THR A 1 412 ? 134.283 112.783 162.582 1.00 51.18  ? 412 THR A CB  1 
ATOM   3049 O OG1 . THR A 1 412 ? 133.072 112.412 161.916 1.00 51.18  ? 412 THR A OG1 1 
ATOM   3050 C CG2 . THR A 1 412 ? 135.087 111.541 162.898 1.00 51.18  ? 412 THR A CG2 1 
ATOM   3051 N N   . ASP A 1 413 ? 135.319 113.238 165.822 1.00 53.47  ? 413 ASP A N   1 
ATOM   3052 C CA  . ASP A 1 413 ? 136.493 113.423 166.664 1.00 53.47  ? 413 ASP A CA  1 
ATOM   3053 C C   . ASP A 1 413 ? 137.438 112.247 166.482 1.00 53.47  ? 413 ASP A C   1 
ATOM   3054 O O   . ASP A 1 413 ? 137.031 111.088 166.584 1.00 53.47  ? 413 ASP A O   1 
ATOM   3055 C CB  . ASP A 1 413 ? 136.093 113.606 168.122 1.00 53.47  ? 413 ASP A CB  1 
ATOM   3056 C CG  . ASP A 1 413 ? 137.278 113.673 169.041 1.00 53.47  ? 413 ASP A CG  1 
ATOM   3057 O OD1 . ASP A 1 413 ? 138.167 114.532 168.866 1.00 53.47  ? 413 ASP A OD1 1 
ATOM   3058 O OD2 . ASP A 1 413 ? 137.274 112.892 169.994 1.00 53.47  ? 413 ASP A OD2 1 
ATOM   3059 N N   . ILE A 1 414 ? 138.705 112.556 166.209 1.00 54.55  ? 414 ILE A N   1 
ATOM   3060 C CA  . ILE A 1 414 ? 139.663 111.513 165.885 1.00 54.55  ? 414 ILE A CA  1 
ATOM   3061 C C   . ILE A 1 414 ? 140.428 111.094 167.131 1.00 54.55  ? 414 ILE A C   1 
ATOM   3062 O O   . ILE A 1 414 ? 140.800 109.926 167.288 1.00 54.55  ? 414 ILE A O   1 
ATOM   3063 C CB  . ILE A 1 414 ? 140.607 111.968 164.760 1.00 54.55  ? 414 ILE A CB  1 
ATOM   3064 C CG1 . ILE A 1 414 ? 139.838 112.456 163.544 1.00 54.55  ? 414 ILE A CG1 1 
ATOM   3065 C CG2 . ILE A 1 414 ? 141.342 110.811 164.213 1.00 54.55  ? 414 ILE A CG2 1 
ATOM   3066 C CD1 . ILE A 1 414 ? 139.800 113.941 163.402 1.00 54.55  ? 414 ILE A CD1 1 
ATOM   3067 N N   . ASP A 1 415 ? 140.643 112.022 168.054 1.00 55.27  ? 415 ASP A N   1 
ATOM   3068 C CA  . ASP A 1 415 ? 141.384 111.744 169.274 1.00 55.27  ? 415 ASP A CA  1 
ATOM   3069 C C   . ASP A 1 415 ? 140.621 110.887 170.271 1.00 55.27  ? 415 ASP A C   1 
ATOM   3070 O O   . ASP A 1 415 ? 141.243 110.378 171.207 1.00 55.27  ? 415 ASP A O   1 
ATOM   3071 C CB  . ASP A 1 415 ? 141.779 113.049 169.961 1.00 55.27  ? 415 ASP A CB  1 
ATOM   3072 C CG  . ASP A 1 415 ? 142.796 113.835 169.181 1.00 55.27  ? 415 ASP A CG  1 
ATOM   3073 O OD1 . ASP A 1 415 ? 143.557 113.228 168.403 1.00 55.27  ? 415 ASP A OD1 1 
ATOM   3074 O OD2 . ASP A 1 415 ? 142.846 115.064 169.371 1.00 55.27  ? 415 ASP A OD2 1 
ATOM   3075 N N   . LYS A 1 416 ? 139.309 110.727 170.088 1.00 55.08  ? 416 LYS A N   1 
ATOM   3076 C CA  . LYS A 1 416 ? 138.407 110.077 171.045 1.00 55.08  ? 416 LYS A CA  1 
ATOM   3077 C C   . LYS A 1 416 ? 138.493 110.729 172.425 1.00 55.08  ? 416 LYS A C   1 
ATOM   3078 O O   . LYS A 1 416 ? 138.541 110.052 173.453 1.00 55.08  ? 416 LYS A O   1 
ATOM   3079 C CB  . LYS A 1 416 ? 138.648 108.567 171.122 1.00 55.08  ? 416 LYS A CB  1 
ATOM   3080 N N   . ASN A 1 417 ? 138.514 112.065 172.447 1.00 54.96  ? 417 ASN A N   1 
ATOM   3081 C CA  . ASN A 1 417 ? 138.524 112.824 173.692 1.00 54.96  ? 417 ASN A CA  1 
ATOM   3082 C C   . ASN A 1 417 ? 137.216 113.544 173.974 1.00 54.96  ? 417 ASN A C   1 
ATOM   3083 O O   . ASN A 1 417 ? 137.011 114.004 175.096 1.00 54.96  ? 417 ASN A O   1 
ATOM   3084 C CB  . ASN A 1 417 ? 139.676 113.825 173.710 1.00 54.96  ? 417 ASN A CB  1 
ATOM   3085 C CG  . ASN A 1 417 ? 139.643 114.782 172.564 1.00 54.96  ? 417 ASN A CG  1 
ATOM   3086 O OD1 . ASN A 1 417 ? 138.772 114.731 171.713 1.00 54.96  ? 417 ASN A OD1 1 
ATOM   3087 N ND2 . ASN A 1 417 ? 140.602 115.689 172.542 1.00 54.96  ? 417 ASN A ND2 1 
ATOM   3088 N N   . GLY A 1 418 ? 136.341 113.669 172.989 1.00 54.45  ? 418 GLY A N   1 
ATOM   3089 C CA  . GLY A 1 418 ? 134.999 114.139 173.240 1.00 54.45  ? 418 GLY A CA  1 
ATOM   3090 C C   . GLY A 1 418 ? 134.606 115.401 172.520 1.00 54.45  ? 418 GLY A C   1 
ATOM   3091 O O   . GLY A 1 418 ? 133.436 115.788 172.586 1.00 54.45  ? 418 GLY A O   1 
ATOM   3092 N N   . TRP A 1 419 ? 135.532 116.049 171.822 1.00 55.35  ? 419 TRP A N   1 
ATOM   3093 C CA  . TRP A 1 419 ? 135.256 117.305 171.138 1.00 55.35  ? 419 TRP A CA  1 
ATOM   3094 C C   . TRP A 1 419 ? 135.512 117.106 169.650 1.00 55.35  ? 419 TRP A C   1 
ATOM   3095 O O   . TRP A 1 419 ? 136.661 116.814 169.268 1.00 55.35  ? 419 TRP A O   1 
ATOM   3096 C CB  . TRP A 1 419 ? 136.135 118.421 171.713 1.00 55.35  ? 419 TRP A CB  1 
ATOM   3097 C CG  . TRP A 1 419 ? 135.772 118.852 173.110 1.00 55.35  ? 419 TRP A CG  1 
ATOM   3098 C CD1 . TRP A 1 419 ? 134.893 119.830 173.454 1.00 55.35  ? 419 TRP A CD1 1 
ATOM   3099 C CD2 . TRP A 1 419 ? 136.292 118.333 174.341 1.00 55.35  ? 419 TRP A CD2 1 
ATOM   3100 N NE1 . TRP A 1 419 ? 134.828 119.953 174.816 1.00 55.35  ? 419 TRP A NE1 1 
ATOM   3101 C CE2 . TRP A 1 419 ? 135.674 119.044 175.386 1.00 55.35  ? 419 TRP A CE2 1 
ATOM   3102 C CE3 . TRP A 1 419 ? 137.215 117.334 174.661 1.00 55.35  ? 419 TRP A CE3 1 
ATOM   3103 C CZ2 . TRP A 1 419 ? 135.945 118.791 176.725 1.00 55.35  ? 419 TRP A CZ2 1 
ATOM   3104 C CZ3 . TRP A 1 419 ? 137.483 117.081 175.995 1.00 55.35  ? 419 TRP A CZ3 1 
ATOM   3105 C CH2 . TRP A 1 419 ? 136.846 117.805 177.010 1.00 55.35  ? 419 TRP A CH2 1 
ATOM   3106 N N   . PRO A 1 420 ? 134.500 117.278 168.782 1.00 52.60  ? 420 PRO A N   1 
ATOM   3107 C CA  . PRO A 1 420 ? 134.647 116.939 167.359 1.00 52.60  ? 420 PRO A CA  1 
ATOM   3108 C C   . PRO A 1 420 ? 135.686 117.792 166.655 1.00 52.60  ? 420 PRO A C   1 
ATOM   3109 O O   . PRO A 1 420 ? 136.060 118.861 167.126 1.00 52.60  ? 420 PRO A O   1 
ATOM   3110 C CB  . PRO A 1 420 ? 133.252 117.208 166.792 1.00 52.60  ? 420 PRO A CB  1 
ATOM   3111 C CG  . PRO A 1 420 ? 132.356 117.136 167.936 1.00 52.60  ? 420 PRO A CG  1 
ATOM   3112 C CD  . PRO A 1 420 ? 133.123 117.678 169.094 1.00 52.60  ? 420 PRO A CD  1 
ATOM   3113 N N   . ASP A 1 421 ? 136.179 117.295 165.531 1.00 52.86  ? 421 ASP A N   1 
ATOM   3114 C CA  . ASP A 1 421 ? 137.313 117.914 164.869 1.00 52.86  ? 421 ASP A CA  1 
ATOM   3115 C C   . ASP A 1 421 ? 136.945 118.256 163.431 1.00 52.86  ? 421 ASP A C   1 
ATOM   3116 O O   . ASP A 1 421 ? 135.960 117.756 162.886 1.00 52.86  ? 421 ASP A O   1 
ATOM   3117 C CB  . ASP A 1 421 ? 138.523 116.993 164.916 1.00 52.86  ? 421 ASP A CB  1 
ATOM   3118 C CG  . ASP A 1 421 ? 138.979 116.707 166.323 1.00 52.86  ? 421 ASP A CG  1 
ATOM   3119 O OD1 . ASP A 1 421 ? 138.748 117.546 167.207 1.00 52.86  ? 421 ASP A OD1 1 
ATOM   3120 O OD2 . ASP A 1 421 ? 139.573 115.641 166.554 1.00 52.86  ? 421 ASP A OD2 1 
ATOM   3121 N N   . LEU A 1 422 ? 137.749 119.119 162.814 1.00 49.84  ? 422 LEU A N   1 
ATOM   3122 C CA  . LEU A 1 422 ? 137.434 119.690 161.511 1.00 49.84  ? 422 LEU A CA  1 
ATOM   3123 C C   . LEU A 1 422 ? 138.605 119.525 160.555 1.00 49.84  ? 422 LEU A C   1 
ATOM   3124 O O   . LEU A 1 422 ? 139.715 119.975 160.849 1.00 49.84  ? 422 LEU A O   1 
ATOM   3125 C CB  . LEU A 1 422 ? 137.074 121.175 161.651 1.00 49.84  ? 422 LEU A CB  1 
ATOM   3126 C CG  . LEU A 1 422 ? 136.773 122.032 160.422 1.00 49.84  ? 422 LEU A CG  1 
ATOM   3127 C CD1 . LEU A 1 422 ? 135.586 121.538 159.657 1.00 49.84  ? 422 LEU A CD1 1 
ATOM   3128 C CD2 . LEU A 1 422 ? 136.548 123.445 160.867 1.00 49.84  ? 422 LEU A CD2 1 
ATOM   3129 N N   . ILE A 1 423 ? 138.345 118.893 159.408 1.00 47.43  ? 423 ILE A N   1 
ATOM   3130 C CA  . ILE A 1 423 ? 139.281 118.841 158.289 1.00 47.43  ? 423 ILE A CA  1 
ATOM   3131 C C   . ILE A 1 423 ? 138.884 119.916 157.287 1.00 47.43  ? 423 ILE A C   1 
ATOM   3132 O O   . ILE A 1 423 ? 137.695 120.141 157.042 1.00 47.43  ? 423 ILE A O   1 
ATOM   3133 C CB  . ILE A 1 423 ? 139.337 117.435 157.642 1.00 47.43  ? 423 ILE A CB  1 
ATOM   3134 C CG1 . ILE A 1 423 ? 140.363 117.380 156.511 1.00 47.43  ? 423 ILE A CG1 1 
ATOM   3135 C CG2 . ILE A 1 423 ? 137.988 116.935 157.185 1.00 47.43  ? 423 ILE A CG2 1 
ATOM   3136 C CD1 . ILE A 1 423 ? 140.556 116.012 155.940 1.00 47.43  ? 423 ILE A CD1 1 
ATOM   3137 N N   . VAL A 1 424 ? 139.879 120.626 156.753 1.00 45.68  ? 424 VAL A N   1 
ATOM   3138 C CA  . VAL A 1 424 ? 139.664 121.695 155.787 1.00 45.68  ? 424 VAL A CA  1 
ATOM   3139 C C   . VAL A 1 424 ? 140.509 121.420 154.551 1.00 45.68  ? 424 VAL A C   1 
ATOM   3140 O O   . VAL A 1 424 ? 141.733 121.315 154.647 1.00 45.68  ? 424 VAL A O   1 
ATOM   3141 C CB  . VAL A 1 424 ? 140.017 123.073 156.374 1.00 45.68  ? 424 VAL A CB  1 
ATOM   3142 C CG1 . VAL A 1 424 ? 139.899 124.129 155.317 1.00 45.68  ? 424 VAL A CG1 1 
ATOM   3143 C CG2 . VAL A 1 424 ? 139.123 123.408 157.547 1.00 45.68  ? 424 VAL A CG2 1 
ATOM   3144 N N   . GLY A 1 425 ? 139.859 121.319 153.395 1.00 41.74  ? 425 GLY A N   1 
ATOM   3145 C CA  . GLY A 1 425 ? 140.559 121.093 152.144 1.00 41.74  ? 425 GLY A CA  1 
ATOM   3146 C C   . GLY A 1 425 ? 140.916 122.403 151.464 1.00 41.74  ? 425 GLY A C   1 
ATOM   3147 O O   . GLY A 1 425 ? 140.102 123.314 151.378 1.00 41.74  ? 425 GLY A O   1 
ATOM   3148 N N   . ALA A 1 426 ? 142.147 122.468 150.961 1.00 41.75  ? 426 ALA A N   1 
ATOM   3149 C CA  . ALA A 1 426 ? 142.761 123.694 150.454 1.00 41.75  ? 426 ALA A CA  1 
ATOM   3150 C C   . ALA A 1 426 ? 143.429 123.424 149.104 1.00 41.75  ? 426 ALA A C   1 
ATOM   3151 O O   . ALA A 1 426 ? 144.626 123.634 148.935 1.00 41.75  ? 426 ALA A O   1 
ATOM   3152 C CB  . ALA A 1 426 ? 143.764 124.258 151.447 1.00 41.75  ? 426 ALA A CB  1 
ATOM   3153 N N   . PHE A 1 427 ? 142.639 122.934 148.140 1.00 38.60  ? 427 PHE A N   1 
ATOM   3154 C CA  . PHE A 1 427 ? 143.153 122.198 146.991 1.00 38.60  ? 427 PHE A CA  1 
ATOM   3155 C C   . PHE A 1 427 ? 143.983 123.020 146.023 1.00 38.60  ? 427 PHE A C   1 
ATOM   3156 O O   . PHE A 1 427 ? 144.536 122.447 145.086 1.00 38.60  ? 427 PHE A O   1 
ATOM   3157 C CB  . PHE A 1 427 ? 142.003 121.566 146.223 1.00 38.60  ? 427 PHE A CB  1 
ATOM   3158 C CG  . PHE A 1 427 ? 141.188 122.527 145.419 1.00 38.60  ? 427 PHE A CG  1 
ATOM   3159 C CD1 . PHE A 1 427 ? 140.179 123.253 145.999 1.00 38.60  ? 427 PHE A CD1 1 
ATOM   3160 C CD2 . PHE A 1 427 ? 141.361 122.622 144.054 1.00 38.60  ? 427 PHE A CD2 1 
ATOM   3161 C CE1 . PHE A 1 427 ? 139.409 124.104 145.239 1.00 38.60  ? 427 PHE A CE1 1 
ATOM   3162 C CE2 . PHE A 1 427 ? 140.605 123.473 143.301 1.00 38.60  ? 427 PHE A CE2 1 
ATOM   3163 C CZ  . PHE A 1 427 ? 139.627 124.211 143.891 1.00 38.60  ? 427 PHE A CZ  1 
ATOM   3164 N N   . GLY A 1 428 ? 144.048 124.335 146.176 1.00 39.61  ? 428 GLY A N   1 
ATOM   3165 C CA  . GLY A 1 428 ? 144.862 125.118 145.265 1.00 39.61  ? 428 GLY A CA  1 
ATOM   3166 C C   . GLY A 1 428 ? 146.339 124.878 145.474 1.00 39.61  ? 428 GLY A C   1 
ATOM   3167 O O   . GLY A 1 428 ? 147.131 124.958 144.538 1.00 39.61  ? 428 GLY A O   1 
ATOM   3168 N N   . VAL A 1 429 ? 146.725 124.572 146.707 1.00 42.29  ? 429 VAL A N   1 
ATOM   3169 C CA  . VAL A 1 429 ? 148.078 124.168 147.031 1.00 42.29  ? 429 VAL A CA  1 
ATOM   3170 C C   . VAL A 1 429 ? 148.156 122.685 147.355 1.00 42.29  ? 429 VAL A C   1 
ATOM   3171 O O   . VAL A 1 429 ? 149.185 122.220 147.852 1.00 42.29  ? 429 VAL A O   1 
ATOM   3172 C CB  . VAL A 1 429 ? 148.623 125.010 148.185 1.00 42.29  ? 429 VAL A CB  1 
ATOM   3173 C CG1 . VAL A 1 429 ? 148.769 126.447 147.743 1.00 42.29  ? 429 VAL A CG1 1 
ATOM   3174 C CG2 . VAL A 1 429 ? 147.672 124.940 149.340 1.00 42.29  ? 429 VAL A CG2 1 
ATOM   3175 N N   . ASP A 1 430 ? 147.071 121.942 147.103 1.00 43.03  ? 430 ASP A N   1 
ATOM   3176 C CA  . ASP A 1 430 ? 146.965 120.484 147.223 1.00 43.03  ? 430 ASP A CA  1 
ATOM   3177 C C   . ASP A 1 430 ? 147.211 120.017 148.656 1.00 43.03  ? 430 ASP A C   1 
ATOM   3178 O O   . ASP A 1 430 ? 147.991 119.105 148.917 1.00 43.03  ? 430 ASP A O   1 
ATOM   3179 C CB  . ASP A 1 430 ? 147.911 119.780 146.252 1.00 43.03  ? 430 ASP A CB  1 
ATOM   3180 C CG  . ASP A 1 430 ? 147.616 120.113 144.827 1.00 43.03  ? 430 ASP A CG  1 
ATOM   3181 O OD1 . ASP A 1 430 ? 146.442 120.362 144.505 1.00 43.03  ? 430 ASP A OD1 1 
ATOM   3182 O OD2 . ASP A 1 430 ? 148.567 120.162 144.028 1.00 43.03  ? 430 ASP A OD2 1 
ATOM   3183 N N   . ARG A 1 431 ? 146.520 120.663 149.588 1.00 43.49  ? 431 ARG A N   1 
ATOM   3184 C CA  . ARG A 1 431 ? 146.660 120.372 151.003 1.00 43.49  ? 431 ARG A CA  1 
ATOM   3185 C C   . ARG A 1 431 ? 145.314 119.964 151.572 1.00 43.49  ? 431 ARG A C   1 
ATOM   3186 O O   . ARG A 1 431 ? 144.268 120.158 150.954 1.00 43.49  ? 431 ARG A O   1 
ATOM   3187 C CB  . ARG A 1 431 ? 147.184 121.573 151.778 1.00 43.49  ? 431 ARG A CB  1 
ATOM   3188 C CG  . ARG A 1 431 ? 148.562 122.025 151.399 1.00 43.49  ? 431 ARG A CG  1 
ATOM   3189 C CD  . ARG A 1 431 ? 149.596 121.085 151.906 1.00 43.49  ? 431 ARG A CD  1 
ATOM   3190 N NE  . ARG A 1 431 ? 150.932 121.628 151.739 1.00 43.49  ? 431 ARG A NE  1 
ATOM   3191 C CZ  . ARG A 1 431 ? 151.677 121.444 150.660 1.00 43.49  ? 431 ARG A CZ  1 
ATOM   3192 N NH1 . ARG A 1 431 ? 151.212 120.732 149.646 1.00 43.49  ? 431 ARG A NH1 1 
ATOM   3193 N NH2 . ARG A 1 431 ? 152.887 121.974 150.592 1.00 43.49  ? 431 ARG A NH2 1 
ATOM   3194 N N   . ALA A 1 432 ? 145.350 119.392 152.766 1.00 46.95  ? 432 ALA A N   1 
ATOM   3195 C CA  . ALA A 1 432 ? 144.140 119.084 153.509 1.00 46.95  ? 432 ALA A CA  1 
ATOM   3196 C C   . ALA A 1 432 ? 144.491 119.093 154.984 1.00 46.95  ? 432 ALA A C   1 
ATOM   3197 O O   . ALA A 1 432 ? 145.066 118.130 155.491 1.00 46.95  ? 432 ALA A O   1 
ATOM   3198 C CB  . ALA A 1 432 ? 143.560 117.734 153.099 1.00 46.95  ? 432 ALA A CB  1 
ATOM   3199 N N   . ILE A 1 433 ? 144.137 120.170 155.667 1.00 48.72  ? 433 ILE A N   1 
ATOM   3200 C CA  . ILE A 1 433 ? 144.575 120.433 157.027 1.00 48.72  ? 433 ILE A CA  1 
ATOM   3201 C C   . ILE A 1 433 ? 143.506 119.923 157.988 1.00 48.72  ? 433 ILE A C   1 
ATOM   3202 O O   . ILE A 1 433 ? 142.313 119.940 157.667 1.00 48.72  ? 433 ILE A O   1 
ATOM   3203 C CB  . ILE A 1 433 ? 144.870 121.933 157.201 1.00 48.72  ? 433 ILE A CB  1 
ATOM   3204 C CG1 . ILE A 1 433 ? 145.527 122.245 158.529 1.00 48.72  ? 433 ILE A CG1 1 
ATOM   3205 C CG2 . ILE A 1 433 ? 143.664 122.776 156.963 1.00 48.72  ? 433 ILE A CG2 1 
ATOM   3206 C CD1 . ILE A 1 433 ? 146.896 121.817 158.550 1.00 48.72  ? 433 ILE A CD1 1 
ATOM   3207 N N   . LEU A 1 434 ? 143.934 119.413 159.141 1.00 50.80  ? 434 LEU A N   1 
ATOM   3208 C CA  . LEU A 1 434 ? 143.037 118.884 160.160 1.00 50.80  ? 434 LEU A CA  1 
ATOM   3209 C C   . LEU A 1 434 ? 143.223 119.676 161.443 1.00 50.80  ? 434 LEU A C   1 
ATOM   3210 O O   . LEU A 1 434 ? 144.350 119.835 161.918 1.00 50.80  ? 434 LEU A O   1 
ATOM   3211 C CB  . LEU A 1 434 ? 143.302 117.406 160.423 1.00 50.80  ? 434 LEU A CB  1 
ATOM   3212 C CG  . LEU A 1 434 ? 142.382 116.726 161.440 1.00 50.80  ? 434 LEU A CG  1 
ATOM   3213 C CD1 . LEU A 1 434 ? 140.953 116.650 160.943 1.00 50.80  ? 434 LEU A CD1 1 
ATOM   3214 C CD2 . LEU A 1 434 ? 142.883 115.346 161.768 1.00 50.80  ? 434 LEU A CD2 1 
ATOM   3215 N N   . TYR A 1 435 ? 142.124 120.163 162.000 1.00 51.91  ? 435 TYR A N   1 
ATOM   3216 C CA  . TYR A 1 435 ? 142.143 120.919 163.239 1.00 51.91  ? 435 TYR A CA  1 
ATOM   3217 C C   . TYR A 1 435 ? 141.546 120.076 164.350 1.00 51.91  ? 435 TYR A C   1 
ATOM   3218 O O   . TYR A 1 435 ? 140.555 119.377 164.140 1.00 51.91  ? 435 TYR A O   1 
ATOM   3219 C CB  . TYR A 1 435 ? 141.364 122.228 163.091 1.00 51.91  ? 435 TYR A CB  1 
ATOM   3220 C CG  . TYR A 1 435 ? 142.019 123.206 162.144 1.00 51.91  ? 435 TYR A CG  1 
ATOM   3221 C CD1 . TYR A 1 435 ? 143.039 124.033 162.575 1.00 51.91  ? 435 TYR A CD1 1 
ATOM   3222 C CD2 . TYR A 1 435 ? 141.634 123.276 160.819 1.00 51.91  ? 435 TYR A CD2 1 
ATOM   3223 C CE1 . TYR A 1 435 ? 143.645 124.909 161.723 1.00 51.91  ? 435 TYR A CE1 1 
ATOM   3224 C CE2 . TYR A 1 435 ? 142.239 124.147 159.961 1.00 51.91  ? 435 TYR A CE2 1 
ATOM   3225 C CZ  . TYR A 1 435 ? 143.243 124.962 160.418 1.00 51.91  ? 435 TYR A CZ  1 
ATOM   3226 O OH  . TYR A 1 435 ? 143.848 125.842 159.559 1.00 51.91  ? 435 TYR A OH  1 
ATOM   3227 N N   . ARG A 1 436 ? 142.151 120.148 165.532 1.00 53.78  ? 436 ARG A N   1 
ATOM   3228 C CA  . ARG A 1 436 ? 141.742 119.349 166.676 1.00 53.78  ? 436 ARG A CA  1 
ATOM   3229 C C   . ARG A 1 436 ? 141.199 120.254 167.764 1.00 53.78  ? 436 ARG A C   1 
ATOM   3230 O O   . ARG A 1 436 ? 141.868 121.201 168.180 1.00 53.78  ? 436 ARG A O   1 
ATOM   3231 C CB  . ARG A 1 436 ? 142.908 118.525 167.212 1.00 53.78  ? 436 ARG A CB  1 
ATOM   3232 C CG  . ARG A 1 436 ? 143.313 117.414 166.291 1.00 53.78  ? 436 ARG A CG  1 
ATOM   3233 C CD  . ARG A 1 436 ? 144.361 116.532 166.905 1.00 53.78  ? 436 ARG A CD  1 
ATOM   3234 N NE  . ARG A 1 436 ? 145.669 117.161 166.973 1.00 53.78  ? 436 ARG A NE  1 
ATOM   3235 C CZ  . ARG A 1 436 ? 146.346 117.339 168.095 1.00 53.78  ? 436 ARG A CZ  1 
ATOM   3236 N NH1 . ARG A 1 436 ? 145.842 116.913 169.239 1.00 53.78  ? 436 ARG A NH1 1 
ATOM   3237 N NH2 . ARG A 1 436 ? 147.535 117.921 168.066 1.00 53.78  ? 436 ARG A NH2 1 
ATOM   3238 N N   . ALA A 1 437 ? 139.995 119.955 168.229 1.00 52.37  ? 437 ALA A N   1 
ATOM   3239 C CA  . ALA A 1 437 ? 139.362 120.799 169.223 1.00 52.37  ? 437 ALA A CA  1 
ATOM   3240 C C   . ALA A 1 437 ? 139.952 120.542 170.597 1.00 52.37  ? 437 ALA A C   1 
ATOM   3241 O O   . ALA A 1 437 ? 140.284 119.409 170.948 1.00 52.37  ? 437 ALA A O   1 
ATOM   3242 C CB  . ALA A 1 437 ? 137.866 120.551 169.250 1.00 52.37  ? 437 ALA A CB  1 
ATOM   3243 N N   . ARG A 1 438 ? 140.067 121.602 171.380 1.00 54.30  ? 438 ARG A N   1 
ATOM   3244 C CA  . ARG A 1 438 ? 140.692 121.499 172.681 1.00 54.30  ? 438 ARG A CA  1 
ATOM   3245 C C   . ARG A 1 438 ? 139.646 121.357 173.773 1.00 54.30  ? 438 ARG A C   1 
ATOM   3246 O O   . ARG A 1 438 ? 138.503 121.779 173.589 1.00 54.30  ? 438 ARG A O   1 
ATOM   3247 C CB  . ARG A 1 438 ? 141.556 122.727 172.952 1.00 54.30  ? 438 ARG A CB  1 
ATOM   3248 C CG  . ARG A 1 438 ? 142.754 122.786 172.057 1.00 54.30  ? 438 ARG A CG  1 
ATOM   3249 C CD  . ARG A 1 438 ? 143.632 123.957 172.385 1.00 54.30  ? 438 ARG A CD  1 
ATOM   3250 N NE  . ARG A 1 438 ? 143.002 125.219 172.039 1.00 54.30  ? 438 ARG A NE  1 
ATOM   3251 C CZ  . ARG A 1 438 ? 143.528 126.405 172.312 1.00 54.30  ? 438 ARG A CZ  1 
ATOM   3252 N NH1 . ARG A 1 438 ? 144.695 126.480 172.932 1.00 54.30  ? 438 ARG A NH1 1 
ATOM   3253 N NH2 . ARG A 1 438 ? 142.891 127.513 171.963 1.00 54.30  ? 438 ARG A NH2 1 
ATOM   3254 N N   . PRO A 1 439 ? 140.008 120.734 174.895 1.00 54.90  ? 439 PRO A N   1 
ATOM   3255 C CA  . PRO A 1 439 ? 139.096 120.686 176.037 1.00 54.90  ? 439 PRO A CA  1 
ATOM   3256 C C   . PRO A 1 439 ? 138.866 122.063 176.644 1.00 54.90  ? 439 PRO A C   1 
ATOM   3257 O O   . PRO A 1 439 ? 139.789 122.866 176.793 1.00 54.90  ? 439 PRO A O   1 
ATOM   3258 C CB  . PRO A 1 439 ? 139.819 119.761 177.016 1.00 54.90  ? 439 PRO A CB  1 
ATOM   3259 C CG  . PRO A 1 439 ? 140.667 118.936 176.179 1.00 54.90  ? 439 PRO A CG  1 
ATOM   3260 C CD  . PRO A 1 439 ? 141.140 119.816 175.088 1.00 54.90  ? 439 PRO A CD  1 
ATOM   3261 N N   . VAL A 1 440 ? 137.613 122.322 176.999 1.00 55.89  ? 440 VAL A N   1 
ATOM   3262 C CA  . VAL A 1 440 ? 137.215 123.571 177.617 1.00 55.89  ? 440 VAL A CA  1 
ATOM   3263 C C   . VAL A 1 440 ? 136.795 123.300 179.046 1.00 55.89  ? 440 VAL A C   1 
ATOM   3264 O O   . VAL A 1 440 ? 136.547 122.155 179.416 1.00 55.89  ? 440 VAL A O   1 
ATOM   3265 C CB  . VAL A 1 440 ? 136.082 124.243 176.838 1.00 55.89  ? 440 VAL A CB  1 
ATOM   3266 C CG1 . VAL A 1 440 ? 136.535 124.575 175.433 1.00 55.89  ? 440 VAL A CG1 1 
ATOM   3267 C CG2 . VAL A 1 440 ? 134.872 123.341 176.800 1.00 55.89  ? 440 VAL A CG2 1 
ATOM   3268 N N   . GLU B 2 1   ? 108.628 130.546 91.730  1.00 59.00  ? 1   GLU H N   1 
ATOM   3269 C CA  . GLU B 2 1   ? 109.920 130.685 92.392  1.00 59.00  ? 1   GLU H CA  1 
ATOM   3270 C C   . GLU B 2 1   ? 110.670 131.876 91.829  1.00 59.00  ? 1   GLU H C   1 
ATOM   3271 O O   . GLU B 2 1   ? 110.098 132.675 91.103  1.00 59.00  ? 1   GLU H O   1 
ATOM   3272 C CB  . GLU B 2 1   ? 110.755 129.412 92.237  1.00 59.00  ? 1   GLU H CB  1 
ATOM   3273 C CG  . GLU B 2 1   ? 110.233 128.213 93.020  1.00 59.00  ? 1   GLU H CG  1 
ATOM   3274 C CD  . GLU B 2 1   ? 109.152 127.439 92.284  1.00 59.00  ? 1   GLU H CD  1 
ATOM   3275 O OE1 . GLU B 2 1   ? 108.841 127.791 91.125  1.00 59.00  ? 1   GLU H OE1 1 
ATOM   3276 O OE2 . GLU B 2 1   ? 108.610 126.478 92.868  1.00 59.00  ? 1   GLU H OE2 1 
ATOM   3277 N N   . VAL B 2 2   ? 111.950 131.987 92.163  1.00 55.31  ? 2   VAL H N   1 
ATOM   3278 C CA  . VAL B 2 2   ? 112.760 133.118 91.729  1.00 55.31  ? 2   VAL H CA  1 
ATOM   3279 C C   . VAL B 2 2   ? 113.303 132.827 90.340  1.00 55.31  ? 2   VAL H C   1 
ATOM   3280 O O   . VAL B 2 2   ? 114.003 131.831 90.137  1.00 55.31  ? 2   VAL H O   1 
ATOM   3281 C CB  . VAL B 2 2   ? 113.904 133.385 92.712  1.00 55.31  ? 2   VAL H CB  1 
ATOM   3282 C CG1 . VAL B 2 2   ? 114.733 134.549 92.233  1.00 55.31  ? 2   VAL H CG1 1 
ATOM   3283 C CG2 . VAL B 2 2   ? 113.369 133.643 94.095  1.00 55.31  ? 2   VAL H CG2 1 
ATOM   3284 N N   . GLN B 2 3   ? 112.997 133.699 89.383  1.00 56.06  ? 3   GLN H N   1 
ATOM   3285 C CA  . GLN B 2 3   ? 113.509 133.578 88.023  1.00 56.06  ? 3   GLN H CA  1 
ATOM   3286 C C   . GLN B 2 3   ? 114.505 134.698 87.777  1.00 56.06  ? 3   GLN H C   1 
ATOM   3287 O O   . GLN B 2 3   ? 114.150 135.877 87.841  1.00 56.06  ? 3   GLN H O   1 
ATOM   3288 C CB  . GLN B 2 3   ? 112.391 133.615 86.987  1.00 56.06  ? 3   GLN H CB  1 
ATOM   3289 C CG  . GLN B 2 3   ? 111.519 132.386 86.977  1.00 56.06  ? 3   GLN H CG  1 
ATOM   3290 C CD  . GLN B 2 3   ? 110.368 132.485 87.942  1.00 56.06  ? 3   GLN H CD  1 
ATOM   3291 O OE1 . GLN B 2 3   ? 109.987 133.578 88.357  1.00 56.06  ? 3   GLN H OE1 1 
ATOM   3292 N NE2 . GLN B 2 3   ? 109.806 131.342 88.311  1.00 56.06  ? 3   GLN H NE2 1 
ATOM   3293 N N   . LEU B 2 4   ? 115.743 134.324 87.496  1.00 50.81  ? 4   LEU H N   1 
ATOM   3294 C CA  . LEU B 2 4   ? 116.780 135.265 87.117  1.00 50.81  ? 4   LEU H CA  1 
ATOM   3295 C C   . LEU B 2 4   ? 116.896 135.260 85.598  1.00 50.81  ? 4   LEU H C   1 
ATOM   3296 O O   . LEU B 2 4   ? 117.208 134.226 85.003  1.00 50.81  ? 4   LEU H O   1 
ATOM   3297 C CB  . LEU B 2 4   ? 118.099 134.862 87.762  1.00 50.81  ? 4   LEU H CB  1 
ATOM   3298 C CG  . LEU B 2 4   ? 118.089 134.836 89.280  1.00 50.81  ? 4   LEU H CG  1 
ATOM   3299 C CD1 . LEU B 2 4   ? 119.333 134.189 89.787  1.00 50.81  ? 4   LEU H CD1 1 
ATOM   3300 C CD2 . LEU B 2 4   ? 118.026 136.229 89.782  1.00 50.81  ? 4   LEU H CD2 1 
ATOM   3301 N N   . VAL B 2 5   ? 116.630 136.401 84.970  1.00 52.13  ? 5   VAL H N   1 
ATOM   3302 C CA  . VAL B 2 5   ? 116.650 136.531 83.519  1.00 52.13  ? 5   VAL H CA  1 
ATOM   3303 C C   . VAL B 2 5   ? 117.731 137.528 83.150  1.00 52.13  ? 5   VAL H C   1 
ATOM   3304 O O   . VAL B 2 5   ? 117.724 138.660 83.639  1.00 52.13  ? 5   VAL H O   1 
ATOM   3305 C CB  . VAL B 2 5   ? 115.287 136.981 82.976  1.00 52.13  ? 5   VAL H CB  1 
ATOM   3306 C CG1 . VAL B 2 5   ? 115.365 137.215 81.488  1.00 52.13  ? 5   VAL H CG1 1 
ATOM   3307 C CG2 . VAL B 2 5   ? 114.230 135.947 83.297  1.00 52.13  ? 5   VAL H CG2 1 
ATOM   3308 N N   . GLN B 2 6   ? 118.650 137.118 82.289  1.00 51.31  ? 6   GLN H N   1 
ATOM   3309 C CA  . GLN B 2 6   ? 119.802 137.935 81.959  1.00 51.31  ? 6   GLN H CA  1 
ATOM   3310 C C   . GLN B 2 6   ? 119.615 138.649 80.628  1.00 51.31  ? 6   GLN H C   1 
ATOM   3311 O O   . GLN B 2 6   ? 118.562 138.592 79.993  1.00 51.31  ? 6   GLN H O   1 
ATOM   3312 C CB  . GLN B 2 6   ? 121.067 137.090 81.896  1.00 51.31  ? 6   GLN H CB  1 
ATOM   3313 C CG  . GLN B 2 6   ? 121.490 136.481 83.189  1.00 51.31  ? 6   GLN H CG  1 
ATOM   3314 C CD  . GLN B 2 6   ? 122.811 135.787 83.054  1.00 51.31  ? 6   GLN H CD  1 
ATOM   3315 O OE1 . GLN B 2 6   ? 123.401 135.762 81.986  1.00 51.31  ? 6   GLN H OE1 1 
ATOM   3316 N NE2 . GLN B 2 6   ? 123.280 135.213 84.129  1.00 51.31  ? 6   GLN H NE2 1 
ATOM   3317 N N   . SER B 2 7   ? 120.679 139.318 80.196  1.00 51.19  ? 7   SER H N   1 
ATOM   3318 C CA  . SER B 2 7   ? 120.707 139.995 78.916  1.00 51.19  ? 7   SER H CA  1 
ATOM   3319 C C   . SER B 2 7   ? 121.136 139.026 77.820  1.00 51.19  ? 7   SER H C   1 
ATOM   3320 O O   . SER B 2 7   ? 121.444 137.860 78.067  1.00 51.19  ? 7   SER H O   1 
ATOM   3321 C CB  . SER B 2 7   ? 121.637 141.196 78.985  1.00 51.19  ? 7   SER H CB  1 
ATOM   3322 O OG  . SER B 2 7   ? 122.966 140.779 79.210  1.00 51.19  ? 7   SER H OG  1 
ATOM   3323 N N   . GLY B 2 8   ? 121.161 139.516 76.588  1.00 51.26  ? 8   GLY H N   1 
ATOM   3324 C CA  . GLY B 2 8   ? 121.460 138.680 75.446  1.00 51.26  ? 8   GLY H CA  1 
ATOM   3325 C C   . GLY B 2 8   ? 122.940 138.397 75.308  1.00 51.26  ? 8   GLY H C   1 
ATOM   3326 O O   . GLY B 2 8   ? 123.770 138.797 76.121  1.00 51.26  ? 8   GLY H O   1 
ATOM   3327 N N   . ALA B 2 9   ? 123.272 137.681 74.241  1.00 49.63  ? 9   ALA H N   1 
ATOM   3328 C CA  . ALA B 2 9   ? 124.653 137.308 74.006  1.00 49.63  ? 9   ALA H CA  1 
ATOM   3329 C C   . ALA B 2 9   ? 125.440 138.497 73.487  1.00 49.63  ? 9   ALA H C   1 
ATOM   3330 O O   . ALA B 2 9   ? 124.905 139.399 72.846  1.00 49.63  ? 9   ALA H O   1 
ATOM   3331 C CB  . ALA B 2 9   ? 124.736 136.157 73.012  1.00 49.63  ? 9   ALA H CB  1 
ATOM   3332 N N   . GLU B 2 10  ? 126.735 138.489 73.763  1.00 51.58  ? 10  GLU H N   1 
ATOM   3333 C CA  . GLU B 2 10  ? 127.574 139.633 73.465  1.00 51.58  ? 10  GLU H CA  1 
ATOM   3334 C C   . GLU B 2 10  ? 128.793 139.180 72.686  1.00 51.58  ? 10  GLU H C   1 
ATOM   3335 O O   . GLU B 2 10  ? 129.151 138.003 72.679  1.00 51.58  ? 10  GLU H O   1 
ATOM   3336 C CB  . GLU B 2 10  ? 128.024 140.350 74.742  1.00 51.58  ? 10  GLU H CB  1 
ATOM   3337 C CG  . GLU B 2 10  ? 126.895 140.950 75.565  1.00 51.58  ? 10  GLU H CG  1 
ATOM   3338 C CD  . GLU B 2 10  ? 126.205 142.103 74.872  1.00 51.58  ? 10  GLU H CD  1 
ATOM   3339 O OE1 . GLU B 2 10  ? 126.884 142.855 74.142  1.00 51.58  ? 10  GLU H OE1 1 
ATOM   3340 O OE2 . GLU B 2 10  ? 124.979 142.253 75.053  1.00 51.58  ? 10  GLU H OE2 1 
ATOM   3341 N N   . VAL B 2 11  ? 129.426 140.140 72.028  1.00 51.21  ? 11  VAL H N   1 
ATOM   3342 C CA  . VAL B 2 11  ? 130.709 139.944 71.368  1.00 51.21  ? 11  VAL H CA  1 
ATOM   3343 C C   . VAL B 2 11  ? 131.422 141.288 71.361  1.00 51.21  ? 11  VAL H C   1 
ATOM   3344 O O   . VAL B 2 11  ? 130.807 142.322 71.092  1.00 51.21  ? 11  VAL H O   1 
ATOM   3345 C CB  . VAL B 2 11  ? 130.529 139.331 69.960  1.00 51.21  ? 11  VAL H CB  1 
ATOM   3346 C CG1 . VAL B 2 11  ? 129.581 140.142 69.100  1.00 51.21  ? 11  VAL H CG1 1 
ATOM   3347 C CG2 . VAL B 2 11  ? 131.864 139.164 69.263  1.00 51.21  ? 11  VAL H CG2 1 
ATOM   3348 N N   . LYS B 2 12  ? 132.699 141.294 71.730  1.00 53.19  ? 12  LYS H N   1 
ATOM   3349 C CA  . LYS B 2 12  ? 133.374 142.561 71.963  1.00 53.19  ? 12  LYS H CA  1 
ATOM   3350 C C   . LYS B 2 12  ? 134.877 142.386 71.857  1.00 53.19  ? 12  LYS H C   1 
ATOM   3351 O O   . LYS B 2 12  ? 135.444 141.541 72.546  1.00 53.19  ? 12  LYS H O   1 
ATOM   3352 C CB  . LYS B 2 12  ? 133.013 143.117 73.345  1.00 53.19  ? 12  LYS H CB  1 
ATOM   3353 N N   . LYS B 2 13  ? 135.514 143.252 71.060  1.00 54.49  ? 13  LYS H N   1 
ATOM   3354 C CA  . LYS B 2 13  ? 136.950 143.242 70.802  1.00 54.49  ? 13  LYS H CA  1 
ATOM   3355 C C   . LYS B 2 13  ? 137.755 143.408 72.094  1.00 54.49  ? 13  LYS H C   1 
ATOM   3356 O O   . LYS B 2 13  ? 137.235 143.921 73.083  1.00 54.49  ? 13  LYS H O   1 
ATOM   3357 C CB  . LYS B 2 13  ? 137.279 144.367 69.817  1.00 54.49  ? 13  LYS H CB  1 
ATOM   3358 N N   . PRO B 2 14  ? 139.015 142.949 72.120  1.00 55.54  ? 14  PRO H N   1 
ATOM   3359 C CA  . PRO B 2 14  ? 139.808 143.043 73.351  1.00 55.54  ? 14  PRO H CA  1 
ATOM   3360 C C   . PRO B 2 14  ? 140.120 144.477 73.740  1.00 55.54  ? 14  PRO H C   1 
ATOM   3361 O O   . PRO B 2 14  ? 140.298 145.358 72.897  1.00 55.54  ? 14  PRO H O   1 
ATOM   3362 C CB  . PRO B 2 14  ? 141.093 142.289 73.005  1.00 55.54  ? 14  PRO H CB  1 
ATOM   3363 C CG  . PRO B 2 14  ? 140.720 141.391 71.925  1.00 55.54  ? 14  PRO H CG  1 
ATOM   3364 C CD  . PRO B 2 14  ? 139.708 142.120 71.119  1.00 55.54  ? 14  PRO H CD  1 
ATOM   3365 N N   . GLY B 2 15  ? 140.189 144.701 75.049  1.00 54.97  ? 15  GLY H N   1 
ATOM   3366 C CA  . GLY B 2 15  ? 140.375 146.041 75.561  1.00 54.97  ? 15  GLY H CA  1 
ATOM   3367 C C   . GLY B 2 15  ? 139.107 146.845 75.683  1.00 54.97  ? 15  GLY H C   1 
ATOM   3368 O O   . GLY B 2 15  ? 139.168 148.073 75.745  1.00 54.97  ? 15  GLY H O   1 
ATOM   3369 N N   . ALA B 2 16  ? 137.958 146.191 75.727  1.00 54.56  ? 16  ALA H N   1 
ATOM   3370 C CA  . ALA B 2 16  ? 136.664 146.846 75.810  1.00 54.56  ? 16  ALA H CA  1 
ATOM   3371 C C   . ALA B 2 16  ? 135.990 146.442 77.114  1.00 54.56  ? 16  ALA H C   1 
ATOM   3372 O O   . ALA B 2 16  ? 136.629 145.933 78.031  1.00 54.56  ? 16  ALA H O   1 
ATOM   3373 C CB  . ALA B 2 16  ? 135.804 146.506 74.594  1.00 54.56  ? 16  ALA H CB  1 
ATOM   3374 N N   . SER B 2 17  ? 134.695 146.721 77.211  1.00 53.77  ? 17  SER H N   1 
ATOM   3375 C CA  . SER B 2 17  ? 133.908 146.355 78.376  1.00 53.77  ? 17  SER H CA  1 
ATOM   3376 C C   . SER B 2 17  ? 132.613 145.681 77.946  1.00 53.77  ? 17  SER H C   1 
ATOM   3377 O O   . SER B 2 17  ? 132.235 145.705 76.776  1.00 53.77  ? 17  SER H O   1 
ATOM   3378 C CB  . SER B 2 17  ? 133.601 147.574 79.242  1.00 53.77  ? 17  SER H CB  1 
ATOM   3379 O OG  . SER B 2 17  ? 132.774 148.490 78.548  1.00 53.77  ? 17  SER H OG  1 
ATOM   3380 N N   . VAL B 2 18  ? 131.931 145.077 78.913  1.00 53.42  ? 18  VAL H N   1 
ATOM   3381 C CA  . VAL B 2 18  ? 130.658 144.409 78.681  1.00 53.42  ? 18  VAL H CA  1 
ATOM   3382 C C   . VAL B 2 18  ? 129.833 144.495 79.959  1.00 53.42  ? 18  VAL H C   1 
ATOM   3383 O O   . VAL B 2 18  ? 130.358 144.345 81.064  1.00 53.42  ? 18  VAL H O   1 
ATOM   3384 C CB  . VAL B 2 18  ? 130.870 142.954 78.192  1.00 53.42  ? 18  VAL H CB  1 
ATOM   3385 C CG1 . VAL B 2 18  ? 131.713 142.141 79.159  1.00 53.42  ? 18  VAL H CG1 1 
ATOM   3386 C CG2 . VAL B 2 18  ? 129.549 142.253 77.927  1.00 53.42  ? 18  VAL H CG2 1 
ATOM   3387 N N   . LYS B 2 19  ? 128.551 144.801 79.814  1.00 52.41  ? 19  LYS H N   1 
ATOM   3388 C CA  . LYS B 2 19  ? 127.660 144.980 80.951  1.00 52.41  ? 19  LYS H CA  1 
ATOM   3389 C C   . LYS B 2 19  ? 126.513 144.000 80.810  1.00 52.41  ? 19  LYS H C   1 
ATOM   3390 O O   . LYS B 2 19  ? 125.659 144.166 79.937  1.00 52.41  ? 19  LYS H O   1 
ATOM   3391 C CB  . LYS B 2 19  ? 127.134 146.410 81.024  1.00 52.41  ? 19  LYS H CB  1 
ATOM   3392 N N   . VAL B 2 20  ? 126.485 142.993 81.662  1.00 52.35  ? 20  VAL H N   1 
ATOM   3393 C CA  . VAL B 2 20  ? 125.439 141.984 81.626  1.00 52.35  ? 20  VAL H CA  1 
ATOM   3394 C C   . VAL B 2 20  ? 124.419 142.292 82.707  1.00 52.35  ? 20  VAL H C   1 
ATOM   3395 O O   . VAL B 2 20  ? 124.738 142.905 83.731  1.00 52.35  ? 20  VAL H O   1 
ATOM   3396 C CB  . VAL B 2 20  ? 126.021 140.569 81.783  1.00 52.35  ? 20  VAL H CB  1 
ATOM   3397 C CG1 . VAL B 2 20  ? 126.908 140.244 80.604  1.00 52.35  ? 20  VAL H CG1 1 
ATOM   3398 C CG2 . VAL B 2 20  ? 126.808 140.455 83.061  1.00 52.35  ? 20  VAL H CG2 1 
ATOM   3399 N N   . SER B 2 21  ? 123.185 141.891 82.467  1.00 52.49  ? 21  SER H N   1 
ATOM   3400 C CA  . SER B 2 21  ? 122.084 142.152 83.368  1.00 52.49  ? 21  SER H CA  1 
ATOM   3401 C C   . SER B 2 21  ? 121.672 140.860 84.049  1.00 52.49  ? 21  SER H C   1 
ATOM   3402 O O   . SER B 2 21  ? 121.997 139.767 83.590  1.00 52.49  ? 21  SER H O   1 
ATOM   3403 C CB  . SER B 2 21  ? 120.899 142.737 82.607  1.00 52.49  ? 21  SER H CB  1 
ATOM   3404 O OG  . SER B 2 21  ? 121.260 143.942 81.963  1.00 52.49  ? 21  SER H OG  1 
ATOM   3405 N N   . CYS B 2 22  ? 120.971 140.996 85.168  1.00 54.51  ? 22  CYS H N   1 
ATOM   3406 C CA  . CYS B 2 22  ? 120.364 139.850 85.836  1.00 54.51  ? 22  CYS H CA  1 
ATOM   3407 C C   . CYS B 2 22  ? 119.189 140.373 86.642  1.00 54.51  ? 22  CYS H C   1 
ATOM   3408 O O   . CYS B 2 22  ? 119.376 140.866 87.754  1.00 54.51  ? 22  CYS H O   1 
ATOM   3409 C CB  . CYS B 2 22  ? 121.363 139.119 86.732  1.00 54.51  ? 22  CYS H CB  1 
ATOM   3410 S SG  . CYS B 2 22  ? 120.677 137.665 87.584  1.00 54.51  ? 22  CYS H SG  1 
ATOM   3411 N N   . LYS B 2 23  ? 117.992 140.258 86.097  1.00 55.60  ? 23  LYS H N   1 
ATOM   3412 C CA  . LYS B 2 23  ? 116.805 140.815 86.728  1.00 55.60  ? 23  LYS H CA  1 
ATOM   3413 C C   . LYS B 2 23  ? 116.220 139.762 87.651  1.00 55.60  ? 23  LYS H C   1 
ATOM   3414 O O   . LYS B 2 23  ? 115.655 138.767 87.194  1.00 55.60  ? 23  LYS H O   1 
ATOM   3415 C CB  . LYS B 2 23  ? 115.784 141.262 85.693  1.00 55.60  ? 23  LYS H CB  1 
ATOM   3416 C CG  . LYS B 2 23  ? 114.562 141.916 86.315  1.00 55.60  ? 23  LYS H CG  1 
ATOM   3417 C CD  . LYS B 2 23  ? 113.586 142.426 85.268  1.00 55.60  ? 23  LYS H CD  1 
ATOM   3418 C CE  . LYS B 2 23  ? 112.371 143.060 85.926  1.00 55.60  ? 23  LYS H CE  1 
ATOM   3419 N NZ  . LYS B 2 23  ? 111.394 143.563 84.925  1.00 55.60  ? 23  LYS H NZ  1 
ATOM   3420 N N   . ALA B 2 24  ? 116.352 139.989 88.951  1.00 55.73  ? 24  ALA H N   1 
ATOM   3421 C CA  . ALA B 2 24  ? 115.732 139.109 89.924  1.00 55.73  ? 24  ALA H CA  1 
ATOM   3422 C C   . ALA B 2 24  ? 114.224 139.280 89.892  1.00 55.73  ? 24  ALA H C   1 
ATOM   3423 O O   . ALA B 2 24  ? 113.705 140.373 89.672  1.00 55.73  ? 24  ALA H O   1 
ATOM   3424 C CB  . ALA B 2 24  ? 116.270 139.400 91.321  1.00 55.73  ? 24  ALA H CB  1 
ATOM   3425 N N   . SER B 2 25  ? 113.513 138.184 90.101  1.00 56.17  ? 25  SER H N   1 
ATOM   3426 C CA  . SER B 2 25  ? 112.068 138.232 90.027  1.00 56.17  ? 25  SER H CA  1 
ATOM   3427 C C   . SER B 2 25  ? 111.516 137.229 91.023  1.00 56.17  ? 25  SER H C   1 
ATOM   3428 O O   . SER B 2 25  ? 112.228 136.785 91.928  1.00 56.17  ? 25  SER H O   1 
ATOM   3429 C CB  . SER B 2 25  ? 111.596 137.964 88.591  1.00 56.17  ? 25  SER H CB  1 
ATOM   3430 O OG  . SER B 2 25  ? 110.183 137.942 88.526  1.00 56.17  ? 25  SER H OG  1 
ATOM   3431 N N   . GLY B 2 26  ? 110.243 136.876 90.861  1.00 58.35  ? 26  GLY H N   1 
ATOM   3432 C CA  . GLY B 2 26  ? 109.620 135.871 91.695  1.00 58.35  ? 26  GLY H CA  1 
ATOM   3433 C C   . GLY B 2 26  ? 109.426 136.320 93.124  1.00 58.35  ? 26  GLY H C   1 
ATOM   3434 O O   . GLY B 2 26  ? 108.521 137.099 93.426  1.00 58.35  ? 26  GLY H O   1 
ATOM   3435 N N   . TYR B 2 27  ? 110.272 135.820 94.014  1.00 58.00  ? 27  TYR H N   1 
ATOM   3436 C CA  . TYR B 2 27  ? 110.196 136.117 95.438  1.00 58.00  ? 27  TYR H CA  1 
ATOM   3437 C C   . TYR B 2 27  ? 111.477 136.821 95.858  1.00 58.00  ? 27  TYR H C   1 
ATOM   3438 O O   . TYR B 2 27  ? 112.506 136.174 96.067  1.00 58.00  ? 27  TYR H O   1 
ATOM   3439 C CB  . TYR B 2 27  ? 109.985 134.838 96.243  1.00 58.00  ? 27  TYR H CB  1 
ATOM   3440 N N   . THR B 2 28  ? 111.411 138.138 95.999  1.00 57.29  ? 28  THR H N   1 
ATOM   3441 C CA  . THR B 2 28  ? 112.547 138.937 96.438  1.00 57.29  ? 28  THR H CA  1 
ATOM   3442 C C   . THR B 2 28  ? 112.267 139.457 97.841  1.00 57.29  ? 28  THR H C   1 
ATOM   3443 O O   . THR B 2 28  ? 111.298 140.195 98.051  1.00 57.29  ? 28  THR H O   1 
ATOM   3444 C CB  . THR B 2 28  ? 112.807 140.092 95.474  1.00 57.29  ? 28  THR H CB  1 
ATOM   3445 O OG1 . THR B 2 28  ? 111.643 140.925 95.404  1.00 57.29  ? 28  THR H OG1 1 
ATOM   3446 C CG2 . THR B 2 28  ? 113.127 139.560 94.092  1.00 57.29  ? 28  THR H CG2 1 
ATOM   3447 N N   . PHE B 2 29  ? 113.112 139.068 98.796  1.00 54.89  ? 29  PHE H N   1 
ATOM   3448 C CA  . PHE B 2 29  ? 112.949 139.443 100.194 1.00 54.89  ? 29  PHE H CA  1 
ATOM   3449 C C   . PHE B 2 29  ? 114.083 140.312 100.701 1.00 54.89  ? 29  PHE H C   1 
ATOM   3450 O O   . PHE B 2 29  ? 114.255 140.422 101.919 1.00 54.89  ? 29  PHE H O   1 
ATOM   3451 C CB  . PHE B 2 29  ? 112.833 138.194 101.059 1.00 54.89  ? 29  PHE H CB  1 
ATOM   3452 C CG  . PHE B 2 29  ? 111.625 137.383 100.762 1.00 54.89  ? 29  PHE H CG  1 
ATOM   3453 C CD1 . PHE B 2 29  ? 110.392 137.758 101.261 1.00 54.89  ? 29  PHE H CD1 1 
ATOM   3454 C CD2 . PHE B 2 29  ? 111.715 136.255 99.974  1.00 54.89  ? 29  PHE H CD2 1 
ATOM   3455 C CE1 . PHE B 2 29  ? 109.266 137.016 100.988 1.00 54.89  ? 29  PHE H CE1 1 
ATOM   3456 C CE2 . PHE B 2 29  ? 110.596 135.505 99.700  1.00 54.89  ? 29  PHE H CE2 1 
ATOM   3457 C CZ  . PHE B 2 29  ? 109.367 135.887 100.204 1.00 54.89  ? 29  PHE H CZ  1 
ATOM   3458 N N   . THR B 2 30  ? 114.921 140.823 99.794  1.00 50.51  ? 30  THR H N   1 
ATOM   3459 C CA  . THR B 2 30  ? 115.893 141.900 99.978  1.00 50.51  ? 30  THR H CA  1 
ATOM   3460 C C   . THR B 2 30  ? 117.105 141.438 100.799 1.00 50.51  ? 30  THR H C   1 
ATOM   3461 O O   . THR B 2 30  ? 118.117 142.142 100.877 1.00 50.51  ? 30  THR H O   1 
ATOM   3462 C CB  . THR B 2 30  ? 115.179 143.129 100.580 1.00 50.51  ? 30  THR H CB  1 
ATOM   3463 O OG1 . THR B 2 30  ? 113.942 143.318 99.886  1.00 50.51  ? 30  THR H OG1 1 
ATOM   3464 C CG2 . THR B 2 30  ? 115.979 144.423 100.402 1.00 50.51  ? 30  THR H CG2 1 
ATOM   3465 N N   . ASN B 2 31  ? 117.070 140.224 101.347 1.00 48.32  ? 31  ASN H N   1 
ATOM   3466 C CA  . ASN B 2 31  ? 118.222 139.658 102.032 1.00 48.32  ? 31  ASN H CA  1 
ATOM   3467 C C   . ASN B 2 31  ? 119.070 138.777 101.134 1.00 48.32  ? 31  ASN H C   1 
ATOM   3468 O O   . ASN B 2 31  ? 119.842 137.959 101.640 1.00 48.32  ? 31  ASN H O   1 
ATOM   3469 C CB  . ASN B 2 31  ? 117.791 138.879 103.274 1.00 48.32  ? 31  ASN H CB  1 
ATOM   3470 C CG  . ASN B 2 31  ? 116.792 137.776 102.982 1.00 48.32  ? 31  ASN H CG  1 
ATOM   3471 O OD1 . ASN B 2 31  ? 116.425 137.509 101.841 1.00 48.32  ? 31  ASN H OD1 1 
ATOM   3472 N ND2 . ASN B 2 31  ? 116.338 137.123 104.042 1.00 48.32  ? 31  ASN H ND2 1 
ATOM   3473 N N   . TYR B 2 32  ? 118.936 138.913 99.823  1.00 47.52  ? 32  TYR H N   1 
ATOM   3474 C CA  . TYR B 2 32  ? 119.652 138.074 98.887  1.00 47.52  ? 32  TYR H CA  1 
ATOM   3475 C C   . TYR B 2 32  ? 120.827 138.829 98.287  1.00 47.52  ? 32  TYR H C   1 
ATOM   3476 O O   . TYR B 2 32  ? 120.933 140.047 98.403  1.00 47.52  ? 32  TYR H O   1 
ATOM   3477 C CB  . TYR B 2 32  ? 118.711 137.569 97.799  1.00 47.52  ? 32  TYR H CB  1 
ATOM   3478 C CG  . TYR B 2 32  ? 118.099 138.600 96.897  1.00 47.52  ? 32  TYR H CG  1 
ATOM   3479 C CD1 . TYR B 2 32  ? 116.927 139.237 97.241  1.00 47.52  ? 32  TYR H CD1 1 
ATOM   3480 C CD2 . TYR B 2 32  ? 118.648 138.867 95.658  1.00 47.52  ? 32  TYR H CD2 1 
ATOM   3481 C CE1 . TYR B 2 32  ? 116.350 140.153 96.403  1.00 47.52  ? 32  TYR H CE1 1 
ATOM   3482 C CE2 . TYR B 2 32  ? 118.078 139.772 94.812  1.00 47.52  ? 32  TYR H CE2 1 
ATOM   3483 C CZ  . TYR B 2 32  ? 116.934 140.418 95.189  1.00 47.52  ? 32  TYR H CZ  1 
ATOM   3484 O OH  . TYR B 2 32  ? 116.367 141.335 94.337  1.00 47.52  ? 32  TYR H OH  1 
ATOM   3485 N N   . GLY B 2 33  ? 121.732 138.079 97.677  1.00 46.18  ? 33  GLY H N   1 
ATOM   3486 C CA  . GLY B 2 33  ? 122.840 138.664 96.954  1.00 46.18  ? 33  GLY H CA  1 
ATOM   3487 C C   . GLY B 2 33  ? 123.058 137.934 95.648  1.00 46.18  ? 33  GLY H C   1 
ATOM   3488 O O   . GLY B 2 33  ? 123.013 136.710 95.585  1.00 46.18  ? 33  GLY H O   1 
ATOM   3489 N N   . ILE B 2 34  ? 123.294 138.708 94.596  1.00 47.39  ? 34  ILE H N   1 
ATOM   3490 C CA  . ILE B 2 34  ? 123.470 138.171 93.256  1.00 47.39  ? 34  ILE H CA  1 
ATOM   3491 C C   . ILE B 2 34  ? 124.954 137.996 93.007  1.00 47.39  ? 34  ILE H C   1 
ATOM   3492 O O   . ILE B 2 34  ? 125.732 138.943 93.156  1.00 47.39  ? 34  ILE H O   1 
ATOM   3493 C CB  . ILE B 2 34  ? 122.837 139.061 92.180  1.00 47.39  ? 34  ILE H CB  1 
ATOM   3494 C CG1 . ILE B 2 34  ? 121.328 139.101 92.350  1.00 47.39  ? 34  ILE H CG1 1 
ATOM   3495 C CG2 . ILE B 2 34  ? 123.155 138.538 90.801  1.00 47.39  ? 34  ILE H CG2 1 
ATOM   3496 C CD1 . ILE B 2 34  ? 120.685 137.781 92.140  1.00 47.39  ? 34  ILE H CD1 1 
ATOM   3497 N N   . ASN B 2 35  ? 125.341 136.787 92.631  1.00 48.02  ? 35  ASN H N   1 
ATOM   3498 C CA  . ASN B 2 35  ? 126.710 136.431 92.310  1.00 48.02  ? 35  ASN H CA  1 
ATOM   3499 C C   . ASN B 2 35  ? 126.865 136.378 90.804  1.00 48.02  ? 35  ASN H C   1 
ATOM   3500 O O   . ASN B 2 35  ? 125.886 136.444 90.067  1.00 48.02  ? 35  ASN H O   1 
ATOM   3501 C CB  . ASN B 2 35  ? 127.031 135.075 92.918  1.00 48.02  ? 35  ASN H CB  1 
ATOM   3502 C CG  . ASN B 2 35  ? 126.902 135.092 94.393  1.00 48.02  ? 35  ASN H CG  1 
ATOM   3503 O OD1 . ASN B 2 35  ? 127.505 135.907 95.042  1.00 48.02  ? 35  ASN H OD1 1 
ATOM   3504 N ND2 . ASN B 2 35  ? 126.014 134.280 94.923  1.00 48.02  ? 35  ASN H ND2 1 
ATOM   3505 N N   . TRP B 2 36  ? 128.104 136.275 90.349  1.00 48.67  ? 36  TRP H N   1 
ATOM   3506 C CA  . TRP B 2 36  ? 128.384 135.933 88.965  1.00 48.67  ? 36  TRP H CA  1 
ATOM   3507 C C   . TRP B 2 36  ? 129.503 134.912 88.906  1.00 48.67  ? 36  TRP H C   1 
ATOM   3508 O O   . TRP B 2 36  ? 130.473 134.987 89.663  1.00 48.67  ? 36  TRP H O   1 
ATOM   3509 C CB  . TRP B 2 36  ? 128.736 137.155 88.124  1.00 48.67  ? 36  TRP H CB  1 
ATOM   3510 C CG  . TRP B 2 36  ? 127.535 137.902 87.630  1.00 48.67  ? 36  TRP H CG  1 
ATOM   3511 C CD1 . TRP B 2 36  ? 126.878 137.705 86.462  1.00 48.67  ? 36  TRP H CD1 1 
ATOM   3512 C CD2 . TRP B 2 36  ? 126.845 138.945 88.302  1.00 48.67  ? 36  TRP H CD2 1 
ATOM   3513 N NE1 . TRP B 2 36  ? 125.827 138.565 86.359  1.00 48.67  ? 36  TRP H NE1 1 
ATOM   3514 C CE2 . TRP B 2 36  ? 125.784 139.339 87.481  1.00 48.67  ? 36  TRP H CE2 1 
ATOM   3515 C CE3 . TRP B 2 36  ? 127.025 139.585 89.524  1.00 48.67  ? 36  TRP H CE3 1 
ATOM   3516 C CZ2 . TRP B 2 36  ? 124.911 140.342 87.836  1.00 48.67  ? 36  TRP H CZ2 1 
ATOM   3517 C CZ3 . TRP B 2 36  ? 126.160 140.587 89.876  1.00 48.67  ? 36  TRP H CZ3 1 
ATOM   3518 C CH2 . TRP B 2 36  ? 125.120 140.959 89.037  1.00 48.67  ? 36  TRP H CH2 1 
ATOM   3519 N N   . VAL B 2 37  ? 129.343 133.948 88.012  1.00 46.90  ? 37  VAL H N   1 
ATOM   3520 C CA  . VAL B 2 37  ? 130.267 132.839 87.869  1.00 46.90  ? 37  VAL H CA  1 
ATOM   3521 C C   . VAL B 2 37  ? 130.578 132.674 86.387  1.00 46.90  ? 37  VAL H C   1 
ATOM   3522 O O   . VAL B 2 37  ? 129.742 132.957 85.522  1.00 46.90  ? 37  VAL H O   1 
ATOM   3523 C CB  . VAL B 2 37  ? 129.689 131.555 88.511  1.00 46.90  ? 37  VAL H CB  1 
ATOM   3524 C CG1 . VAL B 2 37  ? 128.468 131.120 87.813  1.00 46.90  ? 37  VAL H CG1 1 
ATOM   3525 C CG2 . VAL B 2 37  ? 130.698 130.413 88.572  1.00 46.90  ? 37  VAL H CG2 1 
ATOM   3526 N N   . ARG B 2 38  ? 131.813 132.300 86.098  1.00 47.29  ? 38  ARG H N   1 
ATOM   3527 C CA  . ARG B 2 38  ? 132.336 132.216 84.750  1.00 47.29  ? 38  ARG H CA  1 
ATOM   3528 C C   . ARG B 2 38  ? 132.601 130.758 84.423  1.00 47.29  ? 38  ARG H C   1 
ATOM   3529 O O   . ARG B 2 38  ? 133.239 130.055 85.209  1.00 47.29  ? 38  ARG H O   1 
ATOM   3530 C CB  . ARG B 2 38  ? 133.613 133.044 84.646  1.00 47.29  ? 38  ARG H CB  1 
ATOM   3531 C CG  . ARG B 2 38  ? 134.226 132.991 83.324  1.00 47.29  ? 38  ARG H CG  1 
ATOM   3532 C CD  . ARG B 2 38  ? 135.297 134.005 83.119  1.00 47.29  ? 38  ARG H CD  1 
ATOM   3533 N NE  . ARG B 2 38  ? 136.544 133.647 83.758  1.00 47.29  ? 38  ARG H NE  1 
ATOM   3534 C CZ  . ARG B 2 38  ? 137.618 134.420 83.742  1.00 47.29  ? 38  ARG H CZ  1 
ATOM   3535 N NH1 . ARG B 2 38  ? 137.582 135.582 83.117  1.00 47.29  ? 38  ARG H NH1 1 
ATOM   3536 N NH2 . ARG B 2 38  ? 138.732 134.017 84.328  1.00 47.29  ? 38  ARG H NH2 1 
ATOM   3537 N N   . GLN B 2 39  ? 132.111 130.296 83.278  1.00 48.33  ? 39  GLN H N   1 
ATOM   3538 C CA  . GLN B 2 39  ? 132.397 128.939 82.821  1.00 48.33  ? 39  GLN H CA  1 
ATOM   3539 C C   . GLN B 2 39  ? 133.061 129.022 81.455  1.00 48.33  ? 39  GLN H C   1 
ATOM   3540 O O   . GLN B 2 39  ? 132.379 129.065 80.429  1.00 48.33  ? 39  GLN H O   1 
ATOM   3541 C CB  . GLN B 2 39  ? 131.141 128.077 82.782  1.00 48.33  ? 39  GLN H CB  1 
ATOM   3542 C CG  . GLN B 2 39  ? 131.449 126.611 82.529  1.00 48.33  ? 39  GLN H CG  1 
ATOM   3543 C CD  . GLN B 2 39  ? 130.275 125.701 82.786  1.00 48.33  ? 39  GLN H CD  1 
ATOM   3544 O OE1 . GLN B 2 39  ? 129.187 126.151 83.116  1.00 48.33  ? 39  GLN H OE1 1 
ATOM   3545 N NE2 . GLN B 2 39  ? 130.498 124.408 82.657  1.00 48.33  ? 39  GLN H NE2 1 
ATOM   3546 N N   . ALA B 2 40  ? 134.393 129.038 81.460  1.00 51.91  ? 40  ALA H N   1 
ATOM   3547 C CA  . ALA B 2 40  ? 135.186 128.972 80.250  1.00 51.91  ? 40  ALA H CA  1 
ATOM   3548 C C   . ALA B 2 40  ? 134.939 127.644 79.540  1.00 51.91  ? 40  ALA H C   1 
ATOM   3549 O O   . ALA B 2 40  ? 134.617 126.646 80.188  1.00 51.91  ? 40  ALA H O   1 
ATOM   3550 C CB  . ALA B 2 40  ? 136.663 129.128 80.598  1.00 51.91  ? 40  ALA H CB  1 
ATOM   3551 N N   . PRO B 2 41  ? 135.053 127.607 78.193  1.00 54.42  ? 41  PRO H N   1 
ATOM   3552 C CA  . PRO B 2 41  ? 134.646 126.399 77.459  1.00 54.42  ? 41  PRO H CA  1 
ATOM   3553 C C   . PRO B 2 41  ? 135.563 125.212 77.689  1.00 54.42  ? 41  PRO H C   1 
ATOM   3554 O O   . PRO B 2 41  ? 136.685 125.167 77.176  1.00 54.42  ? 41  PRO H O   1 
ATOM   3555 C CB  . PRO B 2 41  ? 134.691 126.845 75.994  1.00 54.42  ? 41  PRO H CB  1 
ATOM   3556 C CG  . PRO B 2 41  ? 134.584 128.315 76.040  1.00 54.42  ? 41  PRO H CG  1 
ATOM   3557 C CD  . PRO B 2 41  ? 135.325 128.718 77.268  1.00 54.42  ? 41  PRO H CD  1 
ATOM   3558 N N   . GLY B 2 42  ? 135.076 124.239 78.450  1.00 54.71  ? 42  GLY H N   1 
ATOM   3559 C CA  . GLY B 2 42  ? 135.884 123.093 78.800  1.00 54.71  ? 42  GLY H CA  1 
ATOM   3560 C C   . GLY B 2 42  ? 136.670 123.267 80.075  1.00 54.71  ? 42  GLY H C   1 
ATOM   3561 O O   . GLY B 2 42  ? 137.667 122.568 80.283  1.00 54.71  ? 42  GLY H O   1 
ATOM   3562 N N   . GLN B 2 43  ? 136.266 124.199 80.931  1.00 54.69  ? 43  GLN H N   1 
ATOM   3563 C CA  . GLN B 2 43  ? 136.891 124.378 82.231  1.00 54.69  ? 43  GLN H CA  1 
ATOM   3564 C C   . GLN B 2 43  ? 135.811 124.537 83.288  1.00 54.69  ? 43  GLN H C   1 
ATOM   3565 O O   . GLN B 2 43  ? 134.627 124.676 82.980  1.00 54.69  ? 43  GLN H O   1 
ATOM   3566 C CB  . GLN B 2 43  ? 137.839 125.582 82.260  1.00 54.69  ? 43  GLN H CB  1 
ATOM   3567 C CG  . GLN B 2 43  ? 139.154 125.366 81.540  1.00 54.69  ? 43  GLN H CG  1 
ATOM   3568 C CD  . GLN B 2 43  ? 139.044 125.566 80.050  1.00 54.69  ? 43  GLN H CD  1 
ATOM   3569 O OE1 . GLN B 2 43  ? 138.085 126.156 79.564  1.00 54.69  ? 43  GLN H OE1 1 
ATOM   3570 N NE2 . GLN B 2 43  ? 140.024 125.063 79.311  1.00 54.69  ? 43  GLN H NE2 1 
ATOM   3571 N N   . GLY B 2 44  ? 136.238 124.513 84.544  1.00 50.70  ? 44  GLY H N   1 
ATOM   3572 C CA  . GLY B 2 44  ? 135.307 124.544 85.650  1.00 50.70  ? 44  GLY H CA  1 
ATOM   3573 C C   . GLY B 2 44  ? 134.714 125.920 85.894  1.00 50.70  ? 44  GLY H C   1 
ATOM   3574 O O   . GLY B 2 44  ? 135.049 126.914 85.251  1.00 50.70  ? 44  GLY H O   1 
ATOM   3575 N N   . LEU B 2 45  ? 133.801 125.959 86.857  1.00 44.99  ? 45  LEU H N   1 
ATOM   3576 C CA  . LEU B 2 45  ? 133.127 127.190 87.220  1.00 44.99  ? 45  LEU H CA  1 
ATOM   3577 C C   . LEU B 2 45  ? 134.069 128.098 87.994  1.00 44.99  ? 45  LEU H C   1 
ATOM   3578 O O   . LEU B 2 45  ? 134.912 127.640 88.765  1.00 44.99  ? 45  LEU H O   1 
ATOM   3579 C CB  . LEU B 2 45  ? 131.909 126.864 88.055  1.00 44.99  ? 45  LEU H CB  1 
ATOM   3580 C CG  . LEU B 2 45  ? 130.888 126.043 87.299  1.00 44.99  ? 45  LEU H CG  1 
ATOM   3581 C CD1 . LEU B 2 45  ? 129.850 125.555 88.253  1.00 44.99  ? 45  LEU H CD1 1 
ATOM   3582 C CD2 . LEU B 2 45  ? 130.254 126.903 86.249  1.00 44.99  ? 45  LEU H CD2 1 
ATOM   3583 N N   . GLU B 2 46  ? 133.928 129.402 87.785  1.00 47.18  ? 46  GLU H N   1 
ATOM   3584 C CA  . GLU B 2 46  ? 134.865 130.363 88.342  1.00 47.18  ? 46  GLU H CA  1 
ATOM   3585 C C   . GLU B 2 46  ? 134.143 131.531 88.985  1.00 47.18  ? 46  GLU H C   1 
ATOM   3586 O O   . GLU B 2 46  ? 133.412 132.262 88.320  1.00 47.18  ? 46  GLU H O   1 
ATOM   3587 C CB  . GLU B 2 46  ? 135.812 130.889 87.276  1.00 47.18  ? 46  GLU H CB  1 
ATOM   3588 C CG  . GLU B 2 46  ? 136.786 131.914 87.796  1.00 47.18  ? 46  GLU H CG  1 
ATOM   3589 C CD  . GLU B 2 46  ? 137.779 131.337 88.777  1.00 47.18  ? 46  GLU H CD  1 
ATOM   3590 O OE1 . GLU B 2 46  ? 138.117 130.139 88.665  1.00 47.18  ? 46  GLU H OE1 1 
ATOM   3591 O OE2 . GLU B 2 46  ? 138.225 132.082 89.671  1.00 47.18  ? 46  GLU H OE2 1 
ATOM   3592 N N   . TRP B 2 47  ? 134.425 131.742 90.262  1.00 44.87  ? 47  TRP H N   1 
ATOM   3593 C CA  . TRP B 2 47  ? 133.827 132.799 91.064  1.00 44.87  ? 47  TRP H CA  1 
ATOM   3594 C C   . TRP B 2 47  ? 134.363 134.164 90.683  1.00 44.87  ? 47  TRP H C   1 
ATOM   3595 O O   . TRP B 2 47  ? 135.577 134.372 90.634  1.00 44.87  ? 47  TRP H O   1 
ATOM   3596 C CB  . TRP B 2 47  ? 134.122 132.525 92.526  1.00 44.87  ? 47  TRP H CB  1 
ATOM   3597 C CG  . TRP B 2 47  ? 133.850 133.626 93.484  1.00 44.87  ? 47  TRP H CG  1 
ATOM   3598 C CD1 . TRP B 2 47  ? 134.772 134.414 94.114  1.00 44.87  ? 47  TRP H CD1 1 
ATOM   3599 C CD2 . TRP B 2 47  ? 132.584 134.045 93.950  1.00 44.87  ? 47  TRP H CD2 1 
ATOM   3600 N NE1 . TRP B 2 47  ? 134.149 135.300 94.942  1.00 44.87  ? 47  TRP H NE1 1 
ATOM   3601 C CE2 . TRP B 2 47  ? 132.801 135.093 94.856  1.00 44.87  ? 47  TRP H CE2 1 
ATOM   3602 C CE3 . TRP B 2 47  ? 131.283 133.644 93.682  1.00 44.87  ? 47  TRP H CE3 1 
ATOM   3603 C CZ2 . TRP B 2 47  ? 131.771 135.732 95.493  1.00 44.87  ? 47  TRP H CZ2 1 
ATOM   3604 C CZ3 . TRP B 2 47  ? 130.274 134.276 94.309  1.00 44.87  ? 47  TRP H CZ3 1 
ATOM   3605 C CH2 . TRP B 2 47  ? 130.519 135.305 95.217  1.00 44.87  ? 47  TRP H CH2 1 
ATOM   3606 N N   . MET B 2 48  ? 133.453 135.109 90.473  1.00 47.01  ? 48  MET H N   1 
ATOM   3607 C CA  . MET B 2 48  ? 133.824 136.461 90.100  1.00 47.01  ? 48  MET H CA  1 
ATOM   3608 C C   . MET B 2 48  ? 133.543 137.444 91.228  1.00 47.01  ? 48  MET H C   1 
ATOM   3609 O O   . MET B 2 48  ? 134.441 138.174 91.649  1.00 47.01  ? 48  MET H O   1 
ATOM   3610 C CB  . MET B 2 48  ? 133.089 136.870 88.822  1.00 47.01  ? 48  MET H CB  1 
ATOM   3611 C CG  . MET B 2 48  ? 133.348 135.944 87.665  1.00 47.01  ? 48  MET H CG  1 
ATOM   3612 S SD  . MET B 2 48  ? 132.625 136.518 86.140  1.00 47.01  ? 48  MET H SD  1 
ATOM   3613 C CE  . MET B 2 48  ? 133.789 137.803 85.770  1.00 47.01  ? 48  MET H CE  1 
ATOM   3614 N N   . GLY B 2 49  ? 132.318 137.473 91.736  1.00 47.06  ? 49  GLY H N   1 
ATOM   3615 C CA  . GLY B 2 49  ? 132.031 138.397 92.815  1.00 47.06  ? 49  GLY H CA  1 
ATOM   3616 C C   . GLY B 2 49  ? 130.622 138.255 93.347  1.00 47.06  ? 49  GLY H C   1 
ATOM   3617 O O   . GLY B 2 49  ? 129.855 137.385 92.931  1.00 47.06  ? 49  GLY H O   1 
ATOM   3618 N N   . TYR B 2 50  ? 130.295 139.161 94.269  1.00 46.84  ? 50  TYR H N   1 
ATOM   3619 C CA  . TYR B 2 50  ? 129.074 139.160 95.063  1.00 46.84  ? 50  TYR H CA  1 
ATOM   3620 C C   . TYR B 2 50  ? 128.553 140.582 95.184  1.00 46.84  ? 50  TYR H C   1 
ATOM   3621 O O   . TYR B 2 50  ? 129.337 141.529 95.248  1.00 46.84  ? 50  TYR H O   1 
ATOM   3622 C CB  . TYR B 2 50  ? 129.357 138.572 96.450  1.00 46.84  ? 50  TYR H CB  1 
ATOM   3623 C CG  . TYR B 2 50  ? 128.252 138.642 97.478  1.00 46.84  ? 50  TYR H CG  1 
ATOM   3624 C CD1 . TYR B 2 50  ? 127.134 137.845 97.381  1.00 46.84  ? 50  TYR H CD1 1 
ATOM   3625 C CD2 . TYR B 2 50  ? 128.373 139.457 98.581  1.00 46.84  ? 50  TYR H CD2 1 
ATOM   3626 C CE1 . TYR B 2 50  ? 126.158 137.877 98.312  1.00 46.84  ? 50  TYR H CE1 1 
ATOM   3627 C CE2 . TYR B 2 50  ? 127.392 139.499 99.529  1.00 46.84  ? 50  TYR H CE2 1 
ATOM   3628 C CZ  . TYR B 2 50  ? 126.285 138.701 99.383  1.00 46.84  ? 50  TYR H CZ  1 
ATOM   3629 O OH  . TYR B 2 50  ? 125.291 138.729 100.325 1.00 46.84  ? 50  TYR H OH  1 
ATOM   3630 N N   . PHE B 2 51  ? 127.231 140.729 95.203  1.00 47.02  ? 51  PHE H N   1 
ATOM   3631 C CA  . PHE B 2 51  ? 126.591 142.023 95.399  1.00 47.02  ? 51  PHE H CA  1 
ATOM   3632 C C   . PHE B 2 51  ? 125.370 141.830 96.276  1.00 47.02  ? 51  PHE H C   1 
ATOM   3633 O O   . PHE B 2 51  ? 124.362 141.298 95.812  1.00 47.02  ? 51  PHE H O   1 
ATOM   3634 C CB  . PHE B 2 51  ? 126.165 142.642 94.072  1.00 47.02  ? 51  PHE H CB  1 
ATOM   3635 C CG  . PHE B 2 51  ? 125.701 144.067 94.193  1.00 47.02  ? 51  PHE H CG  1 
ATOM   3636 C CD1 . PHE B 2 51  ? 126.615 145.095 94.197  1.00 47.02  ? 51  PHE H CD1 1 
ATOM   3637 C CD2 . PHE B 2 51  ? 124.362 144.374 94.328  1.00 47.02  ? 51  PHE H CD2 1 
ATOM   3638 C CE1 . PHE B 2 51  ? 126.206 146.388 94.308  1.00 47.02  ? 51  PHE H CE1 1 
ATOM   3639 C CE2 . PHE B 2 51  ? 123.957 145.663 94.454  1.00 47.02  ? 51  PHE H CE2 1 
ATOM   3640 C CZ  . PHE B 2 51  ? 124.877 146.671 94.431  1.00 47.02  ? 51  PHE H CZ  1 
ATOM   3641 N N   . TYR B 2 52  ? 125.435 142.304 97.514  1.00 45.13  ? 52  TYR H N   1 
ATOM   3642 C CA  . TYR B 2 52  ? 124.307 142.189 98.426  1.00 45.13  ? 52  TYR H CA  1 
ATOM   3643 C C   . TYR B 2 52  ? 123.302 143.300 98.146  1.00 45.13  ? 52  TYR H C   1 
ATOM   3644 O O   . TYR B 2 52  ? 123.682 144.453 97.938  1.00 45.13  ? 52  TYR H O   1 
ATOM   3645 C CB  . TYR B 2 52  ? 124.783 142.223 99.877  1.00 45.13  ? 52  TYR H CB  1 
ATOM   3646 C CG  . TYR B 2 52  ? 123.672 142.019 100.867 1.00 45.13  ? 52  TYR H CG  1 
ATOM   3647 C CD1 . TYR B 2 52  ? 122.963 140.831 100.897 1.00 45.13  ? 52  TYR H CD1 1 
ATOM   3648 C CD2 . TYR B 2 52  ? 123.364 142.984 101.794 1.00 45.13  ? 52  TYR H CD2 1 
ATOM   3649 C CE1 . TYR B 2 52  ? 121.961 140.629 101.785 1.00 45.13  ? 52  TYR H CE1 1 
ATOM   3650 C CE2 . TYR B 2 52  ? 122.360 142.788 102.693 1.00 45.13  ? 52  TYR H CE2 1 
ATOM   3651 C CZ  . TYR B 2 52  ? 121.662 141.603 102.683 1.00 45.13  ? 52  TYR H CZ  1 
ATOM   3652 O OH  . TYR B 2 52  ? 120.651 141.394 103.588 1.00 45.13  ? 52  TYR H OH  1 
ATOM   3653 N N   . ILE B 2 53  ? 122.018 142.944 98.133  1.00 45.64  ? 53  ILE H N   1 
ATOM   3654 C CA  . ILE B 2 53  ? 120.988 143.848 97.634  1.00 45.64  ? 53  ILE H CA  1 
ATOM   3655 C C   . ILE B 2 53  ? 120.522 144.846 98.687  1.00 45.64  ? 53  ILE H C   1 
ATOM   3656 O O   . ILE B 2 53  ? 120.131 145.968 98.338  1.00 45.64  ? 53  ILE H O   1 
ATOM   3657 C CB  . ILE B 2 53  ? 119.860 142.981 97.054  1.00 45.64  ? 53  ILE H CB  1 
ATOM   3658 C CG1 . ILE B 2 53  ? 120.439 142.143 95.930  1.00 45.64  ? 53  ILE H CG1 1 
ATOM   3659 C CG2 . ILE B 2 53  ? 118.730 143.785 96.477  1.00 45.64  ? 53  ILE H CG2 1 
ATOM   3660 C CD1 . ILE B 2 53  ? 121.033 142.956 94.827  1.00 45.64  ? 53  ILE H CD1 1 
ATOM   3661 N N   . GLY B 2 54  ? 120.592 144.497 99.965  1.00 44.03  ? 54  GLY H N   1 
ATOM   3662 C CA  . GLY B 2 54  ? 120.250 145.432 101.016 1.00 44.03  ? 54  GLY H CA  1 
ATOM   3663 C C   . GLY B 2 54  ? 121.185 146.618 101.130 1.00 44.03  ? 54  GLY H C   1 
ATOM   3664 O O   . GLY B 2 54  ? 120.735 147.763 101.157 1.00 44.03  ? 54  GLY H O   1 
ATOM   3665 N N   . ASN B 2 55  ? 122.483 146.370 101.187 1.00 45.01  ? 55  ASN H N   1 
ATOM   3666 C CA  . ASN B 2 55  ? 123.435 147.455 101.334 1.00 45.01  ? 55  ASN H CA  1 
ATOM   3667 C C   . ASN B 2 55  ? 123.903 148.013 100.012 1.00 45.01  ? 55  ASN H C   1 
ATOM   3668 O O   . ASN B 2 55  ? 124.209 149.207 99.930  1.00 45.01  ? 55  ASN H O   1 
ATOM   3669 C CB  . ASN B 2 55  ? 124.687 146.992 102.069 1.00 45.01  ? 55  ASN H CB  1 
ATOM   3670 C CG  . ASN B 2 55  ? 124.399 146.482 103.424 1.00 45.01  ? 55  ASN H CG  1 
ATOM   3671 O OD1 . ASN B 2 55  ? 123.511 146.978 104.104 1.00 45.01  ? 55  ASN H OD1 1 
ATOM   3672 N ND2 . ASN B 2 55  ? 125.167 145.495 103.853 1.00 45.01  ? 55  ASN H ND2 1 
ATOM   3673 N N   . GLY B 2 56  ? 123.983 147.178 98.985  1.00 44.02  ? 56  GLY H N   1 
ATOM   3674 C CA  . GLY B 2 56  ? 124.874 147.491 97.900  1.00 44.02  ? 56  GLY H CA  1 
ATOM   3675 C C   . GLY B 2 56  ? 126.294 147.093 98.196  1.00 44.02  ? 56  GLY H C   1 
ATOM   3676 O O   . GLY B 2 56  ? 127.214 147.554 97.521  1.00 44.02  ? 56  GLY H O   1 
ATOM   3677 N N   . TYR B 2 57  ? 126.497 146.252 99.203  1.00 44.40  ? 57  TYR H N   1 
ATOM   3678 C CA  . TYR B 2 57  ? 127.835 145.809 99.558  1.00 44.40  ? 57  TYR H CA  1 
ATOM   3679 C C   . TYR B 2 57  ? 128.353 144.800 98.544  1.00 44.40  ? 57  TYR H C   1 
ATOM   3680 O O   . TYR B 2 57  ? 127.622 143.915 98.090  1.00 44.40  ? 57  TYR H O   1 
ATOM   3681 C CB  . TYR B 2 57  ? 127.840 145.211 100.965 1.00 44.40  ? 57  TYR H CB  1 
ATOM   3682 C CG  . TYR B 2 57  ? 129.147 144.582 101.335 1.00 44.40  ? 57  TYR H CG  1 
ATOM   3683 C CD1 . TYR B 2 57  ? 130.265 145.353 101.573 1.00 44.40  ? 57  TYR H CD1 1 
ATOM   3684 C CD2 . TYR B 2 57  ? 129.266 143.214 101.438 1.00 44.40  ? 57  TYR H CD2 1 
ATOM   3685 C CE1 . TYR B 2 57  ? 131.465 144.773 101.899 1.00 44.40  ? 57  TYR H CE1 1 
ATOM   3686 C CE2 . TYR B 2 57  ? 130.455 142.633 101.766 1.00 44.40  ? 57  TYR H CE2 1 
ATOM   3687 C CZ  . TYR B 2 57  ? 131.549 143.416 101.990 1.00 44.40  ? 57  TYR H CZ  1 
ATOM   3688 O OH  . TYR B 2 57  ? 132.737 142.830 102.310 1.00 44.40  ? 57  TYR H OH  1 
ATOM   3689 N N   . THR B 2 58  ? 129.629 144.942 98.191  1.00 47.38  ? 58  THR H N   1 
ATOM   3690 C CA  . THR B 2 58  ? 130.275 144.116 97.191  1.00 47.38  ? 58  THR H CA  1 
ATOM   3691 C C   . THR B 2 58  ? 131.379 143.291 97.820  1.00 47.38  ? 58  THR H C   1 
ATOM   3692 O O   . THR B 2 58  ? 132.007 143.704 98.794  1.00 47.38  ? 58  THR H O   1 
ATOM   3693 C CB  . THR B 2 58  ? 130.888 144.947 96.087  1.00 47.38  ? 58  THR H CB  1 
ATOM   3694 O OG1 . THR B 2 58  ? 131.950 145.729 96.633  1.00 47.38  ? 58  THR H OG1 1 
ATOM   3695 C CG2 . THR B 2 58  ? 129.865 145.873 95.499  1.00 47.38  ? 58  THR H CG2 1 
ATOM   3696 N N   . GLU B 2 59  ? 131.616 142.121 97.237  1.00 49.76  ? 59  GLU H N   1 
ATOM   3697 C CA  . GLU B 2 59  ? 132.747 141.268 97.566  1.00 49.76  ? 59  GLU H CA  1 
ATOM   3698 C C   . GLU B 2 59  ? 133.270 140.680 96.266  1.00 49.76  ? 59  GLU H C   1 
ATOM   3699 O O   . GLU B 2 59  ? 132.497 140.120 95.490  1.00 49.76  ? 59  GLU H O   1 
ATOM   3700 C CB  . GLU B 2 59  ? 132.347 140.153 98.539  1.00 49.76  ? 59  GLU H CB  1 
ATOM   3701 C CG  . GLU B 2 59  ? 133.492 139.286 98.997  1.00 49.76  ? 59  GLU H CG  1 
ATOM   3702 C CD  . GLU B 2 59  ? 134.444 140.012 99.911  1.00 49.76  ? 59  GLU H CD  1 
ATOM   3703 O OE1 . GLU B 2 59  ? 134.005 140.942 100.612 1.00 49.76  ? 59  GLU H OE1 1 
ATOM   3704 O OE2 . GLU B 2 59  ? 135.637 139.653 99.931  1.00 49.76  ? 59  GLU H OE2 1 
ATOM   3705 N N   . TYR B 2 60  ? 134.574 140.821 96.021  1.00 52.12  ? 60  TYR H N   1 
ATOM   3706 C CA  . TYR B 2 60  ? 135.165 140.503 94.728  1.00 52.12  ? 60  TYR H CA  1 
ATOM   3707 C C   . TYR B 2 60  ? 136.225 139.420 94.860  1.00 52.12  ? 60  TYR H C   1 
ATOM   3708 O O   . TYR B 2 60  ? 136.633 139.044 95.958  1.00 52.12  ? 60  TYR H O   1 
ATOM   3709 C CB  . TYR B 2 60  ? 135.794 141.740 94.077  1.00 52.12  ? 60  TYR H CB  1 
ATOM   3710 C CG  . TYR B 2 60  ? 134.795 142.760 93.584  1.00 52.12  ? 60  TYR H CG  1 
ATOM   3711 C CD1 . TYR B 2 60  ? 133.487 142.399 93.305  1.00 52.12  ? 60  TYR H CD1 1 
ATOM   3712 C CD2 . TYR B 2 60  ? 135.153 144.088 93.437  1.00 52.12  ? 60  TYR H CD2 1 
ATOM   3713 C CE1 . TYR B 2 60  ? 132.575 143.325 92.870  1.00 52.12  ? 60  TYR H CE1 1 
ATOM   3714 C CE2 . TYR B 2 60  ? 134.245 145.020 93.005  1.00 52.12  ? 60  TYR H CE2 1 
ATOM   3715 C CZ  . TYR B 2 60  ? 132.958 144.632 92.726  1.00 52.12  ? 60  TYR H CZ  1 
ATOM   3716 O OH  . TYR B 2 60  ? 132.045 145.557 92.294  1.00 52.12  ? 60  TYR H OH  1 
ATOM   3717 N N   . ASN B 2 61  ? 136.658 138.924 93.706  1.00 51.80  ? 61  ASN H N   1 
ATOM   3718 C CA  . ASN B 2 61  ? 137.727 137.943 93.621  1.00 51.80  ? 61  ASN H CA  1 
ATOM   3719 C C   . ASN B 2 61  ? 139.037 138.660 93.340  1.00 51.80  ? 61  ASN H C   1 
ATOM   3720 O O   . ASN B 2 61  ? 139.077 139.616 92.565  1.00 51.80  ? 61  ASN H O   1 
ATOM   3721 C CB  . ASN B 2 61  ? 137.414 136.942 92.510  1.00 51.80  ? 61  ASN H CB  1 
ATOM   3722 C CG  . ASN B 2 61  ? 138.232 135.686 92.601  1.00 51.80  ? 61  ASN H CG  1 
ATOM   3723 O OD1 . ASN B 2 61  ? 139.071 135.539 93.481  1.00 51.80  ? 61  ASN H OD1 1 
ATOM   3724 N ND2 . ASN B 2 61  ? 137.979 134.756 91.695  1.00 51.80  ? 61  ASN H ND2 1 
ATOM   3725 N N   . GLU B 2 62  ? 140.115 138.202 93.971  1.00 53.01  ? 62  GLU H N   1 
ATOM   3726 C CA  . GLU B 2 62  ? 141.377 138.923 93.860  1.00 53.01  ? 62  GLU H CA  1 
ATOM   3727 C C   . GLU B 2 62  ? 142.075 138.698 92.532  1.00 53.01  ? 62  GLU H C   1 
ATOM   3728 O O   . GLU B 2 62  ? 142.953 139.486 92.174  1.00 53.01  ? 62  GLU H O   1 
ATOM   3729 C CB  . GLU B 2 62  ? 142.311 138.545 95.000  1.00 53.01  ? 62  GLU H CB  1 
ATOM   3730 C CG  . GLU B 2 62  ? 141.896 139.118 96.329  1.00 53.01  ? 62  GLU H CG  1 
ATOM   3731 C CD  . GLU B 2 62  ? 142.839 138.737 97.445  1.00 53.01  ? 62  GLU H CD  1 
ATOM   3732 O OE1 . GLU B 2 62  ? 143.735 137.902 97.208  1.00 53.01  ? 62  GLU H OE1 1 
ATOM   3733 O OE2 . GLU B 2 62  ? 142.688 139.276 98.560  1.00 53.01  ? 62  GLU H OE2 1 
ATOM   3734 N N   . LYS B 2 63  ? 141.721 137.647 91.798  1.00 54.15  ? 63  LYS H N   1 
ATOM   3735 C CA  . LYS B 2 63  ? 142.275 137.468 90.463  1.00 54.15  ? 63  LYS H CA  1 
ATOM   3736 C C   . LYS B 2 63  ? 141.674 138.474 89.492  1.00 54.15  ? 63  LYS H C   1 
ATOM   3737 O O   . LYS B 2 63  ? 142.334 138.920 88.548  1.00 54.15  ? 63  LYS H O   1 
ATOM   3738 C CB  . LYS B 2 63  ? 142.029 136.040 89.984  1.00 54.15  ? 63  LYS H CB  1 
ATOM   3739 N N   . PHE B 2 64  ? 140.422 138.848 89.720  1.00 53.79  ? 64  PHE H N   1 
ATOM   3740 C CA  . PHE B 2 64  ? 139.675 139.753 88.863  1.00 53.79  ? 64  PHE H CA  1 
ATOM   3741 C C   . PHE B 2 64  ? 139.707 141.189 89.353  1.00 53.79  ? 64  PHE H C   1 
ATOM   3742 O O   . PHE B 2 64  ? 138.996 142.026 88.787  1.00 53.79  ? 64  PHE H O   1 
ATOM   3743 C CB  . PHE B 2 64  ? 138.225 139.296 88.803  1.00 53.79  ? 64  PHE H CB  1 
ATOM   3744 C CG  . PHE B 2 64  ? 138.042 137.977 88.161  1.00 53.79  ? 64  PHE H CG  1 
ATOM   3745 C CD1 . PHE B 2 64  ? 138.884 137.557 87.160  1.00 53.79  ? 64  PHE H CD1 1 
ATOM   3746 C CD2 . PHE B 2 64  ? 137.079 137.118 88.624  1.00 53.79  ? 64  PHE H CD2 1 
ATOM   3747 C CE1 . PHE B 2 64  ? 138.722 136.331 86.592  1.00 53.79  ? 64  PHE H CE1 1 
ATOM   3748 C CE2 . PHE B 2 64  ? 136.916 135.883 88.067  1.00 53.79  ? 64  PHE H CE2 1 
ATOM   3749 C CZ  . PHE B 2 64  ? 137.735 135.489 87.052  1.00 53.79  ? 64  PHE H CZ  1 
ATOM   3750 N N   . LYS B 2 65  ? 140.497 141.482 90.386  1.00 57.00  ? 65  LYS H N   1 
ATOM   3751 C CA  . LYS B 2 65  ? 140.352 142.730 91.123  1.00 57.00  ? 65  LYS H CA  1 
ATOM   3752 C C   . LYS B 2 65  ? 140.846 143.902 90.293  1.00 57.00  ? 65  LYS H C   1 
ATOM   3753 O O   . LYS B 2 65  ? 141.884 143.826 89.634  1.00 57.00  ? 65  LYS H O   1 
ATOM   3754 C CB  . LYS B 2 65  ? 141.115 142.646 92.445  1.00 57.00  ? 65  LYS H CB  1 
ATOM   3755 C CG  . LYS B 2 65  ? 140.930 143.831 93.366  1.00 57.00  ? 65  LYS H CG  1 
ATOM   3756 C CD  . LYS B 2 65  ? 141.590 143.575 94.705  1.00 57.00  ? 65  LYS H CD  1 
ATOM   3757 C CE  . LYS B 2 65  ? 143.102 143.589 94.577  1.00 57.00  ? 65  LYS H CE  1 
ATOM   3758 N NZ  . LYS B 2 65  ? 143.613 144.947 94.242  1.00 57.00  ? 65  LYS H NZ  1 
ATOM   3759 N N   . GLY B 2 66  ? 140.076 144.981 90.305  1.00 57.15  ? 66  GLY H N   1 
ATOM   3760 C CA  . GLY B 2 66  ? 140.368 146.119 89.475  1.00 57.15  ? 66  GLY H CA  1 
ATOM   3761 C C   . GLY B 2 66  ? 139.810 146.023 88.080  1.00 57.15  ? 66  GLY H C   1 
ATOM   3762 O O   . GLY B 2 66  ? 140.001 146.954 87.288  1.00 57.15  ? 66  GLY H O   1 
ATOM   3763 N N   . ARG B 2 67  ? 139.133 144.930 87.749  1.00 56.05  ? 67  ARG H N   1 
ATOM   3764 C CA  . ARG B 2 67  ? 138.526 144.763 86.444  1.00 56.05  ? 67  ARG H CA  1 
ATOM   3765 C C   . ARG B 2 67  ? 137.027 144.545 86.502  1.00 56.05  ? 67  ARG H C   1 
ATOM   3766 O O   . ARG B 2 67  ? 136.369 144.644 85.464  1.00 56.05  ? 67  ARG H O   1 
ATOM   3767 C CB  . ARG B 2 67  ? 139.166 143.578 85.706  1.00 56.05  ? 67  ARG H CB  1 
ATOM   3768 C CG  . ARG B 2 67  ? 140.616 143.784 85.352  1.00 56.05  ? 67  ARG H CG  1 
ATOM   3769 C CD  . ARG B 2 67  ? 141.229 142.535 84.747  1.00 56.05  ? 67  ARG H CD  1 
ATOM   3770 N NE  . ARG B 2 67  ? 140.617 142.172 83.477  1.00 56.05  ? 67  ARG H NE  1 
ATOM   3771 C CZ  . ARG B 2 67  ? 139.923 141.060 83.276  1.00 56.05  ? 67  ARG H CZ  1 
ATOM   3772 N NH1 . ARG B 2 67  ? 139.765 140.192 84.257  1.00 56.05  ? 67  ARG H NH1 1 
ATOM   3773 N NH2 . ARG B 2 67  ? 139.398 140.813 82.089  1.00 56.05  ? 67  ARG H NH2 1 
ATOM   3774 N N   . VAL B 2 68  ? 136.470 144.256 87.667  1.00 54.71  ? 68  VAL H N   1 
ATOM   3775 C CA  . VAL B 2 68  ? 135.070 143.895 87.802  1.00 54.71  ? 68  VAL H CA  1 
ATOM   3776 C C   . VAL B 2 68  ? 134.380 144.919 88.692  1.00 54.71  ? 68  VAL H C   1 
ATOM   3777 O O   . VAL B 2 68  ? 134.960 145.404 89.670  1.00 54.71  ? 68  VAL H O   1 
ATOM   3778 C CB  . VAL B 2 68  ? 134.938 142.450 88.335  1.00 54.71  ? 68  VAL H CB  1 
ATOM   3779 C CG1 . VAL B 2 68  ? 135.634 142.274 89.673  1.00 54.71  ? 68  VAL H CG1 1 
ATOM   3780 C CG2 . VAL B 2 68  ? 133.485 142.007 88.402  1.00 54.71  ? 68  VAL H CG2 1 
ATOM   3781 N N   . THR B 2 69  ? 133.170 145.311 88.303  1.00 54.57  ? 69  THR H N   1 
ATOM   3782 C CA  . THR B 2 69  ? 132.385 146.280 89.046  1.00 54.57  ? 69  THR H CA  1 
ATOM   3783 C C   . THR B 2 69  ? 130.926 145.871 88.961  1.00 54.57  ? 69  THR H C   1 
ATOM   3784 O O   . THR B 2 69  ? 130.423 145.552 87.885  1.00 54.57  ? 69  THR H O   1 
ATOM   3785 C CB  . THR B 2 69  ? 132.578 147.697 88.502  1.00 54.57  ? 69  THR H CB  1 
ATOM   3786 O OG1 . THR B 2 69  ? 133.964 148.042 88.565  1.00 54.57  ? 69  THR H OG1 1 
ATOM   3787 C CG2 . THR B 2 69  ? 131.796 148.707 89.316  1.00 54.57  ? 69  THR H CG2 1 
ATOM   3788 N N   . MET B 2 70  ? 130.253 145.860 90.104  1.00 52.38  ? 70  MET H N   1 
ATOM   3789 C CA  . MET B 2 70  ? 128.859 145.458 90.162  1.00 52.38  ? 70  MET H CA  1 
ATOM   3790 C C   . MET B 2 70  ? 128.024 146.588 90.732  1.00 52.38  ? 70  MET H C   1 
ATOM   3791 O O   . MET B 2 70  ? 128.257 147.030 91.860  1.00 52.38  ? 70  MET H O   1 
ATOM   3792 C CB  . MET B 2 70  ? 128.697 144.191 90.996  1.00 52.38  ? 70  MET H CB  1 
ATOM   3793 C CG  . MET B 2 70  ? 129.380 143.009 90.359  1.00 52.38  ? 70  MET H CG  1 
ATOM   3794 S SD  . MET B 2 70  ? 129.382 141.497 91.310  1.00 52.38  ? 70  MET H SD  1 
ATOM   3795 C CE  . MET B 2 70  ? 130.418 140.510 90.239  1.00 52.38  ? 70  MET H CE  1 
ATOM   3796 N N   . THR B 2 71  ? 127.068 147.063 89.941  1.00 51.96  ? 71  THR H N   1 
ATOM   3797 C CA  . THR B 2 71  ? 126.098 148.064 90.345  1.00 51.96  ? 71  THR H CA  1 
ATOM   3798 C C   . THR B 2 71  ? 124.714 147.445 90.232  1.00 51.96  ? 71  THR H C   1 
ATOM   3799 O O   . THR B 2 71  ? 124.575 146.266 89.916  1.00 51.96  ? 71  THR H O   1 
ATOM   3800 C CB  . THR B 2 71  ? 126.214 149.330 89.492  1.00 51.96  ? 71  THR H CB  1 
ATOM   3801 O OG1 . THR B 2 71  ? 125.942 149.013 88.125  1.00 51.96  ? 71  THR H OG1 1 
ATOM   3802 C CG2 . THR B 2 71  ? 127.608 149.904 89.589  1.00 51.96  ? 71  THR H CG2 1 
ATOM   3803 N N   . SER B 2 72  ? 123.677 148.236 90.491  1.00 54.73  ? 72  SER H N   1 
ATOM   3804 C CA  . SER B 2 72  ? 122.333 147.683 90.506  1.00 54.73  ? 72  SER H CA  1 
ATOM   3805 C C   . SER B 2 72  ? 121.290 148.753 90.236  1.00 54.73  ? 72  SER H C   1 
ATOM   3806 O O   . SER B 2 72  ? 121.579 149.951 90.201  1.00 54.73  ? 72  SER H O   1 
ATOM   3807 C CB  . SER B 2 72  ? 122.015 147.023 91.840  1.00 54.73  ? 72  SER H CB  1 
ATOM   3808 O OG  . SER B 2 72  ? 120.678 146.562 91.867  1.00 54.73  ? 72  SER H OG  1 
ATOM   3809 N N   . ASP B 2 73  ? 120.058 148.282 90.057  1.00 59.57  ? 73  ASP H N   1 
ATOM   3810 C CA  . ASP B 2 73  ? 118.871 149.113 89.927  1.00 59.57  ? 73  ASP H CA  1 
ATOM   3811 C C   . ASP B 2 73  ? 117.858 148.595 90.931  1.00 59.57  ? 73  ASP H C   1 
ATOM   3812 O O   . ASP B 2 73  ? 117.510 147.412 90.904  1.00 59.57  ? 73  ASP H O   1 
ATOM   3813 C CB  . ASP B 2 73  ? 118.304 149.045 88.510  1.00 59.57  ? 73  ASP H CB  1 
ATOM   3814 C CG  . ASP B 2 73  ? 117.225 150.079 88.256  1.00 59.57  ? 73  ASP H CG  1 
ATOM   3815 O OD1 . ASP B 2 73  ? 116.947 150.912 89.143  1.00 59.57  ? 73  ASP H OD1 1 
ATOM   3816 O OD2 . ASP B 2 73  ? 116.628 150.039 87.160  1.00 59.57  ? 73  ASP H OD2 1 
ATOM   3817 N N   . THR B 2 74  ? 117.381 149.474 91.807  1.00 62.71  ? 74  THR H N   1 
ATOM   3818 C CA  . THR B 2 74  ? 116.570 149.025 92.932  1.00 62.71  ? 74  THR H CA  1 
ATOM   3819 C C   . THR B 2 74  ? 115.126 148.775 92.524  1.00 62.71  ? 74  THR H C   1 
ATOM   3820 O O   . THR B 2 74  ? 114.535 147.766 92.920  1.00 62.71  ? 74  THR H O   1 
ATOM   3821 C CB  . THR B 2 74  ? 116.639 150.053 94.060  1.00 62.71  ? 74  THR H CB  1 
ATOM   3822 O OG1 . THR B 2 74  ? 118.009 150.265 94.424  1.00 62.71  ? 74  THR H OG1 1 
ATOM   3823 C CG2 . THR B 2 74  ? 115.882 149.568 95.287  1.00 62.71  ? 74  THR H CG2 1 
ATOM   3824 N N   . SER B 2 75  ? 114.549 149.671 91.721  1.00 64.57  ? 75  SER H N   1 
ATOM   3825 C CA  . SER B 2 75  ? 113.124 149.585 91.416  1.00 64.57  ? 75  SER H CA  1 
ATOM   3826 C C   . SER B 2 75  ? 112.822 148.452 90.447  1.00 64.57  ? 75  SER H C   1 
ATOM   3827 O O   . SER B 2 75  ? 111.770 147.813 90.543  1.00 64.57  ? 75  SER H O   1 
ATOM   3828 C CB  . SER B 2 75  ? 112.626 150.914 90.850  1.00 64.57  ? 75  SER H CB  1 
ATOM   3829 O OG  . SER B 2 75  ? 111.251 150.840 90.516  1.00 64.57  ? 75  SER H OG  1 
ATOM   3830 N N   . THR B 2 76  ? 113.723 148.192 89.504  1.00 62.16  ? 76  THR H N   1 
ATOM   3831 C CA  . THR B 2 76  ? 113.520 147.096 88.567  1.00 62.16  ? 76  THR H CA  1 
ATOM   3832 C C   . THR B 2 76  ? 114.154 145.792 89.031  1.00 62.16  ? 76  THR H C   1 
ATOM   3833 O O   . THR B 2 76  ? 113.950 144.767 88.369  1.00 62.16  ? 76  THR H O   1 
ATOM   3834 C CB  . THR B 2 76  ? 114.065 147.468 87.187  1.00 62.16  ? 76  THR H CB  1 
ATOM   3835 O OG1 . THR B 2 76  ? 115.471 147.718 87.279  1.00 62.16  ? 76  THR H OG1 1 
ATOM   3836 C CG2 . THR B 2 76  ? 113.366 148.712 86.656  1.00 62.16  ? 76  THR H CG2 1 
ATOM   3837 N N   . SER B 2 77  ? 114.897 145.820 90.146  1.00 58.70  ? 77  SER H N   1 
ATOM   3838 C CA  . SER B 2 77  ? 115.584 144.665 90.740  1.00 58.70  ? 77  SER H CA  1 
ATOM   3839 C C   . SER B 2 77  ? 116.529 143.999 89.750  1.00 58.70  ? 77  SER H C   1 
ATOM   3840 O O   . SER B 2 77  ? 116.656 142.776 89.707  1.00 58.70  ? 77  SER H O   1 
ATOM   3841 C CB  . SER B 2 77  ? 114.597 143.645 91.308  1.00 58.70  ? 77  SER H CB  1 
ATOM   3842 O OG  . SER B 2 77  ? 113.910 142.969 90.272  1.00 58.70  ? 77  SER H OG  1 
ATOM   3843 N N   . THR B 2 78  ? 117.200 144.810 88.946  1.00 55.91  ? 78  THR H N   1 
ATOM   3844 C CA  . THR B 2 78  ? 118.152 144.326 87.964  1.00 55.91  ? 78  THR H CA  1 
ATOM   3845 C C   . THR B 2 78  ? 119.543 144.695 88.442  1.00 55.91  ? 78  THR H C   1 
ATOM   3846 O O   . THR B 2 78  ? 119.821 145.868 88.694  1.00 55.91  ? 78  THR H O   1 
ATOM   3847 C CB  . THR B 2 78  ? 117.877 144.927 86.592  1.00 55.91  ? 78  THR H CB  1 
ATOM   3848 O OG1 . THR B 2 78  ? 116.532 144.634 86.208  1.00 55.91  ? 78  THR H OG1 1 
ATOM   3849 C CG2 . THR B 2 78  ? 118.807 144.325 85.569  1.00 55.91  ? 78  THR H CG2 1 
ATOM   3850 N N   . VAL B 2 79  ? 120.404 143.703 88.579  1.00 53.67  ? 79  VAL H N   1 
ATOM   3851 C CA  . VAL B 2 79  ? 121.755 143.912 89.076  1.00 53.67  ? 79  VAL H CA  1 
ATOM   3852 C C   . VAL B 2 79  ? 122.713 143.736 87.910  1.00 53.67  ? 79  VAL H C   1 
ATOM   3853 O O   . VAL B 2 79  ? 122.528 142.852 87.069  1.00 53.67  ? 79  VAL H O   1 
ATOM   3854 C CB  . VAL B 2 79  ? 122.072 142.938 90.223  1.00 53.67  ? 79  VAL H CB  1 
ATOM   3855 C CG1 . VAL B 2 79  ? 123.339 143.353 90.961  1.00 53.67  ? 79  VAL H CG1 1 
ATOM   3856 C CG2 . VAL B 2 79  ? 120.891 142.835 91.157  1.00 53.67  ? 79  VAL H CG2 1 
ATOM   3857 N N   . TYR B 2 80  ? 123.729 144.583 87.844  1.00 53.58  ? 80  TYR H N   1 
ATOM   3858 C CA  . TYR B 2 80  ? 124.601 144.659 86.689  1.00 53.58  ? 80  TYR H CA  1 
ATOM   3859 C C   . TYR B 2 80  ? 126.010 144.252 87.077  1.00 53.58  ? 80  TYR H C   1 
ATOM   3860 O O   . TYR B 2 80  ? 126.427 144.451 88.216  1.00 53.58  ? 80  TYR H O   1 
ATOM   3861 C CB  . TYR B 2 80  ? 124.599 146.069 86.117  1.00 53.58  ? 80  TYR H CB  1 
ATOM   3862 C CG  . TYR B 2 80  ? 123.235 146.484 85.640  1.00 53.58  ? 80  TYR H CG  1 
ATOM   3863 C CD1 . TYR B 2 80  ? 122.762 146.081 84.406  1.00 53.58  ? 80  TYR H CD1 1 
ATOM   3864 C CD2 . TYR B 2 80  ? 122.409 147.255 86.439  1.00 53.58  ? 80  TYR H CD2 1 
ATOM   3865 C CE1 . TYR B 2 80  ? 121.515 146.440 83.979  1.00 53.58  ? 80  TYR H CE1 1 
ATOM   3866 C CE2 . TYR B 2 80  ? 121.164 147.619 86.019  1.00 53.58  ? 80  TYR H CE2 1 
ATOM   3867 C CZ  . TYR B 2 80  ? 120.721 147.210 84.788  1.00 53.58  ? 80  TYR H CZ  1 
ATOM   3868 O OH  . TYR B 2 80  ? 119.469 147.576 84.358  1.00 53.58  ? 80  TYR H OH  1 
ATOM   3869 N N   . MET B 2 81  ? 126.726 143.656 86.130  1.00 54.16  ? 81  MET H N   1 
ATOM   3870 C CA  . MET B 2 81  ? 128.145 143.366 86.260  1.00 54.16  ? 81  MET H CA  1 
ATOM   3871 C C   . MET B 2 81  ? 128.858 143.996 85.080  1.00 54.16  ? 81  MET H C   1 
ATOM   3872 O O   . MET B 2 81  ? 128.397 143.868 83.947  1.00 54.16  ? 81  MET H O   1 
ATOM   3873 C CB  . MET B 2 81  ? 128.423 141.867 86.262  1.00 54.16  ? 81  MET H CB  1 
ATOM   3874 C CG  . MET B 2 81  ? 129.888 141.539 86.481  1.00 54.16  ? 81  MET H CG  1 
ATOM   3875 S SD  . MET B 2 81  ? 130.309 139.827 86.197  1.00 54.16  ? 81  MET H SD  1 
ATOM   3876 C CE  . MET B 2 81  ? 130.243 139.784 84.420  1.00 54.16  ? 81  MET H CE  1 
ATOM   3877 N N   . GLU B 2 82  ? 129.974 144.665 85.330  1.00 55.83  ? 82  GLU H N   1 
ATOM   3878 C CA  . GLU B 2 82  ? 130.745 145.268 84.258  1.00 55.83  ? 82  GLU H CA  1 
ATOM   3879 C C   . GLU B 2 82  ? 132.192 144.827 84.361  1.00 55.83  ? 82  GLU H C   1 
ATOM   3880 O O   . GLU B 2 82  ? 132.941 145.339 85.197  1.00 55.83  ? 82  GLU H O   1 
ATOM   3881 C CB  . GLU B 2 82  ? 130.638 146.793 84.287  1.00 55.83  ? 82  GLU H CB  1 
ATOM   3882 C CG  . GLU B 2 82  ? 129.247 147.305 83.912  1.00 55.83  ? 82  GLU H CG  1 
ATOM   3883 C CD  . GLU B 2 82  ? 129.154 148.813 83.836  1.00 55.83  ? 82  GLU H CD  1 
ATOM   3884 O OE1 . GLU B 2 82  ? 130.137 149.495 84.190  1.00 55.83  ? 82  GLU H OE1 1 
ATOM   3885 O OE2 . GLU B 2 82  ? 128.092 149.315 83.414  1.00 55.83  ? 82  GLU H OE2 1 
ATOM   3886 N N   . LEU B 2 83  ? 132.580 143.887 83.505  1.00 55.59  ? 83  LEU H N   1 
ATOM   3887 C CA  . LEU B 2 83  ? 133.978 143.564 83.266  1.00 55.59  ? 83  LEU H CA  1 
ATOM   3888 C C   . LEU B 2 83  ? 134.588 144.601 82.345  1.00 55.59  ? 83  LEU H C   1 
ATOM   3889 O O   . LEU B 2 83  ? 133.978 144.978 81.346  1.00 55.59  ? 83  LEU H O   1 
ATOM   3890 C CB  . LEU B 2 83  ? 134.143 142.185 82.635  1.00 55.59  ? 83  LEU H CB  1 
ATOM   3891 C CG  . LEU B 2 83  ? 134.108 140.940 83.503  1.00 55.59  ? 83  LEU H CG  1 
ATOM   3892 C CD1 . LEU B 2 83  ? 134.107 139.740 82.600  1.00 55.59  ? 83  LEU H CD1 1 
ATOM   3893 C CD2 . LEU B 2 83  ? 135.344 140.935 84.375  1.00 55.59  ? 83  LEU H CD2 1 
ATOM   3894 N N   . SER B 2 84  ? 135.789 145.044 82.676  1.00 55.66  ? 84  SER H N   1 
ATOM   3895 C CA  . SER B 2 84  ? 136.532 145.981 81.860  1.00 55.66  ? 84  SER H CA  1 
ATOM   3896 C C   . SER B 2 84  ? 137.895 145.391 81.553  1.00 55.66  ? 84  SER H C   1 
ATOM   3897 O O   . SER B 2 84  ? 138.339 144.453 82.218  1.00 55.66  ? 84  SER H O   1 
ATOM   3898 C CB  . SER B 2 84  ? 136.691 147.331 82.561  1.00 55.66  ? 84  SER H CB  1 
ATOM   3899 O OG  . SER B 2 84  ? 137.512 147.209 83.708  1.00 55.66  ? 84  SER H OG  1 
ATOM   3900 N N   . SER B 2 85  ? 138.544 145.970 80.538  1.00 54.66  ? 85  SER H N   1 
ATOM   3901 C CA  . SER B 2 85  ? 139.844 145.536 80.022  1.00 54.66  ? 85  SER H CA  1 
ATOM   3902 C C   . SER B 2 85  ? 139.817 144.066 79.622  1.00 54.66  ? 85  SER H C   1 
ATOM   3903 O O   . SER B 2 85  ? 140.606 143.252 80.101  1.00 54.66  ? 85  SER H O   1 
ATOM   3904 C CB  . SER B 2 85  ? 140.964 145.812 81.023  1.00 54.66  ? 85  SER H CB  1 
ATOM   3905 O OG  . SER B 2 85  ? 142.197 145.328 80.530  1.00 54.66  ? 85  SER H OG  1 
ATOM   3906 N N   . LEU B 2 86  ? 138.877 143.734 78.739  1.00 55.34  ? 86  LEU H N   1 
ATOM   3907 C CA  . LEU B 2 86  ? 138.662 142.358 78.317  1.00 55.34  ? 86  LEU H CA  1 
ATOM   3908 C C   . LEU B 2 86  ? 139.839 141.840 77.507  1.00 55.34  ? 86  LEU H C   1 
ATOM   3909 O O   . LEU B 2 86  ? 140.468 142.568 76.738  1.00 55.34  ? 86  LEU H O   1 
ATOM   3910 C CB  . LEU B 2 86  ? 137.382 142.250 77.491  1.00 55.34  ? 86  LEU H CB  1 
ATOM   3911 C CG  . LEU B 2 86  ? 136.033 141.952 78.147  1.00 55.34  ? 86  LEU H CG  1 
ATOM   3912 C CD1 . LEU B 2 86  ? 135.588 143.026 79.093  1.00 55.34  ? 86  LEU H CD1 1 
ATOM   3913 C CD2 . LEU B 2 86  ? 134.993 141.774 77.063  1.00 55.34  ? 86  LEU H CD2 1 
ATOM   3914 N N   . ARG B 2 87  ? 140.135 140.559 77.697  1.00 58.57  ? 87  ARG H N   1 
ATOM   3915 C CA  . ARG B 2 87  ? 141.170 139.848 76.969  1.00 58.57  ? 87  ARG H CA  1 
ATOM   3916 C C   . ARG B 2 87  ? 140.522 138.703 76.208  1.00 58.57  ? 87  ARG H C   1 
ATOM   3917 O O   . ARG B 2 87  ? 139.334 138.422 76.362  1.00 58.57  ? 87  ARG H O   1 
ATOM   3918 C CB  . ARG B 2 87  ? 142.246 139.321 77.919  1.00 58.57  ? 87  ARG H CB  1 
ATOM   3919 C CG  . ARG B 2 87  ? 143.047 140.404 78.592  1.00 58.57  ? 87  ARG H CG  1 
ATOM   3920 C CD  . ARG B 2 87  ? 144.162 139.802 79.415  1.00 58.57  ? 87  ARG H CD  1 
ATOM   3921 N NE  . ARG B 2 87  ? 143.632 138.976 80.493  1.00 58.57  ? 87  ARG H NE  1 
ATOM   3922 C CZ  . ARG B 2 87  ? 143.321 139.436 81.698  1.00 58.57  ? 87  ARG H CZ  1 
ATOM   3923 N NH1 . ARG B 2 87  ? 143.491 140.717 81.984  1.00 58.57  ? 87  ARG H NH1 1 
ATOM   3924 N NH2 . ARG B 2 87  ? 142.843 138.613 82.618  1.00 58.57  ? 87  ARG H NH2 1 
ATOM   3925 N N   . SER B 2 88  ? 141.319 138.023 75.391  1.00 59.28  ? 88  SER H N   1 
ATOM   3926 C CA  . SER B 2 88  ? 140.822 136.891 74.624  1.00 59.28  ? 88  SER H CA  1 
ATOM   3927 C C   . SER B 2 88  ? 140.588 135.659 75.477  1.00 59.28  ? 88  SER H C   1 
ATOM   3928 O O   . SER B 2 88  ? 139.903 134.737 75.024  1.00 59.28  ? 88  SER H O   1 
ATOM   3929 C CB  . SER B 2 88  ? 141.800 136.545 73.505  1.00 59.28  ? 88  SER H CB  1 
ATOM   3930 O OG  . SER B 2 88  ? 143.020 136.071 74.042  1.00 59.28  ? 88  SER H OG  1 
ATOM   3931 N N   . GLU B 2 89  ? 141.136 135.617 76.685  1.00 59.36  ? 89  GLU H N   1 
ATOM   3932 C CA  . GLU B 2 89  ? 140.940 134.506 77.600  1.00 59.36  ? 89  GLU H CA  1 
ATOM   3933 C C   . GLU B 2 89  ? 139.720 134.679 78.487  1.00 59.36  ? 89  GLU H C   1 
ATOM   3934 O O   . GLU B 2 89  ? 139.503 133.857 79.381  1.00 59.36  ? 89  GLU H O   1 
ATOM   3935 C CB  . GLU B 2 89  ? 142.179 134.326 78.468  1.00 59.36  ? 89  GLU H CB  1 
ATOM   3936 C CG  . GLU B 2 89  ? 142.463 135.498 79.371  1.00 59.36  ? 89  GLU H CG  1 
ATOM   3937 C CD  . GLU B 2 89  ? 143.728 135.308 80.182  1.00 59.36  ? 89  GLU H CD  1 
ATOM   3938 O OE1 . GLU B 2 89  ? 144.386 134.260 80.020  1.00 59.36  ? 89  GLU H OE1 1 
ATOM   3939 O OE2 . GLU B 2 89  ? 144.066 136.207 80.980  1.00 59.36  ? 89  GLU H OE2 1 
ATOM   3940 N N   . ASP B 2 90  ? 138.925 135.723 78.266  1.00 56.23  ? 90  ASP H N   1 
ATOM   3941 C CA  . ASP B 2 90  ? 137.700 135.966 79.013  1.00 56.23  ? 90  ASP H CA  1 
ATOM   3942 C C   . ASP B 2 90  ? 136.473 135.445 78.289  1.00 56.23  ? 90  ASP H C   1 
ATOM   3943 O O   . ASP B 2 90  ? 135.351 135.744 78.698  1.00 56.23  ? 90  ASP H O   1 
ATOM   3944 C CB  . ASP B 2 90  ? 137.543 137.457 79.283  1.00 56.23  ? 90  ASP H CB  1 
ATOM   3945 C CG  . ASP B 2 90  ? 138.638 138.003 80.167  1.00 56.23  ? 90  ASP H CG  1 
ATOM   3946 O OD1 . ASP B 2 90  ? 139.187 137.237 80.981  1.00 56.23  ? 90  ASP H OD1 1 
ATOM   3947 O OD2 . ASP B 2 90  ? 138.955 139.200 80.046  1.00 56.23  ? 90  ASP H OD2 1 
ATOM   3948 N N   . THR B 2 91  ? 136.664 134.691 77.217  1.00 53.25  ? 91  THR H N   1 
ATOM   3949 C CA  . THR B 2 91  ? 135.564 134.173 76.425  1.00 53.25  ? 91  THR H CA  1 
ATOM   3950 C C   . THR B 2 91  ? 134.881 133.044 77.178  1.00 53.25  ? 91  THR H C   1 
ATOM   3951 O O   . THR B 2 91  ? 135.482 131.983 77.362  1.00 53.25  ? 91  THR H O   1 
ATOM   3952 C CB  . THR B 2 91  ? 136.111 133.661 75.101  1.00 53.25  ? 91  THR H CB  1 
ATOM   3953 O OG1 . THR B 2 91  ? 136.881 134.689 74.475  1.00 53.25  ? 91  THR H OG1 1 
ATOM   3954 C CG2 . THR B 2 91  ? 134.988 133.235 74.174  1.00 53.25  ? 91  THR H CG2 1 
ATOM   3955 N N   . ALA B 2 92  ? 133.635 133.245 77.601  1.00 47.48  ? 92  ALA H N   1 
ATOM   3956 C CA  . ALA B 2 92  ? 132.977 132.248 78.440  1.00 47.48  ? 92  ALA H CA  1 
ATOM   3957 C C   . ALA B 2 92  ? 131.471 132.447 78.415  1.00 47.48  ? 92  ALA H C   1 
ATOM   3958 O O   . ALA B 2 92  ? 130.938 133.237 77.636  1.00 47.48  ? 92  ALA H O   1 
ATOM   3959 C CB  . ALA B 2 92  ? 133.479 132.318 79.872  1.00 47.48  ? 92  ALA H CB  1 
ATOM   3960 N N   . VAL B 2 93  ? 130.790 131.707 79.286  1.00 45.00  ? 93  VAL H N   1 
ATOM   3961 C CA  . VAL B 2 93  ? 129.353 131.805 79.490  1.00 45.00  ? 93  VAL H CA  1 
ATOM   3962 C C   . VAL B 2 93  ? 129.106 132.202 80.936  1.00 45.00  ? 93  VAL H C   1 
ATOM   3963 O O   . VAL B 2 93  ? 129.574 131.522 81.854  1.00 45.00  ? 93  VAL H O   1 
ATOM   3964 C CB  . VAL B 2 93  ? 128.648 130.483 79.163  1.00 45.00  ? 93  VAL H CB  1 
ATOM   3965 C CG1 . VAL B 2 93  ? 127.182 130.601 79.437  1.00 45.00  ? 93  VAL H CG1 1 
ATOM   3966 C CG2 . VAL B 2 93  ? 128.877 130.116 77.725  1.00 45.00  ? 93  VAL H CG2 1 
ATOM   3967 N N   . TYR B 2 94  ? 128.368 133.292 81.143  1.00 44.85  ? 94  TYR H N   1 
ATOM   3968 C CA  . TYR B 2 94  ? 128.280 133.948 82.443  1.00 44.85  ? 94  TYR H CA  1 
ATOM   3969 C C   . TYR B 2 94  ? 126.908 133.728 83.052  1.00 44.85  ? 94  TYR H C   1 
ATOM   3970 O O   . TYR B 2 94  ? 125.894 134.045 82.428  1.00 44.85  ? 94  TYR H O   1 
ATOM   3971 C CB  . TYR B 2 94  ? 128.539 135.444 82.324  1.00 44.85  ? 94  TYR H CB  1 
ATOM   3972 C CG  . TYR B 2 94  ? 129.943 135.834 81.941  1.00 44.85  ? 94  TYR H CG  1 
ATOM   3973 C CD1 . TYR B 2 94  ? 130.964 134.925 81.955  1.00 44.85  ? 94  TYR H CD1 1 
ATOM   3974 C CD2 . TYR B 2 94  ? 130.247 137.131 81.598  1.00 44.85  ? 94  TYR H CD2 1 
ATOM   3975 C CE1 . TYR B 2 94  ? 132.225 135.276 81.608  1.00 44.85  ? 94  TYR H CE1 1 
ATOM   3976 C CE2 . TYR B 2 94  ? 131.533 137.489 81.257  1.00 44.85  ? 94  TYR H CE2 1 
ATOM   3977 C CZ  . TYR B 2 94  ? 132.512 136.543 81.270  1.00 44.85  ? 94  TYR H CZ  1 
ATOM   3978 O OH  . TYR B 2 94  ? 133.802 136.843 80.943  1.00 44.85  ? 94  TYR H OH  1 
ATOM   3979 N N   . TYR B 2 95  ? 126.880 133.210 84.274  1.00 46.32  ? 95  TYR H N   1 
ATOM   3980 C CA  . TYR B 2 95  ? 125.652 132.937 85.004  1.00 46.32  ? 95  TYR H CA  1 
ATOM   3981 C C   . TYR B 2 95  ? 125.548 133.927 86.152  1.00 46.32  ? 95  TYR H C   1 
ATOM   3982 O O   . TYR B 2 95  ? 126.547 134.513 86.565  1.00 46.32  ? 95  TYR H O   1 
ATOM   3983 C CB  . TYR B 2 95  ? 125.652 131.515 85.558  1.00 46.32  ? 95  TYR H CB  1 
ATOM   3984 C CG  . TYR B 2 95  ? 125.768 130.416 84.535  1.00 46.32  ? 95  TYR H CG  1 
ATOM   3985 C CD1 . TYR B 2 95  ? 125.233 130.546 83.279  1.00 46.32  ? 95  TYR H CD1 1 
ATOM   3986 C CD2 . TYR B 2 95  ? 126.510 129.285 84.806  1.00 46.32  ? 95  TYR H CD2 1 
ATOM   3987 C CE1 . TYR B 2 95  ? 125.363 129.548 82.348  1.00 46.32  ? 95  TYR H CE1 1 
ATOM   3988 C CE2 . TYR B 2 95  ? 126.658 128.292 83.872  1.00 46.32  ? 95  TYR H CE2 1 
ATOM   3989 C CZ  . TYR B 2 95  ? 126.081 128.431 82.648  1.00 46.32  ? 95  TYR H CZ  1 
ATOM   3990 O OH  . TYR B 2 95  ? 126.221 127.440 81.715  1.00 46.32  ? 95  TYR H OH  1 
ATOM   3991 N N   . CYS B 2 96  ? 124.343 134.113 86.679  1.00 49.07  ? 96  CYS H N   1 
ATOM   3992 C CA  . CYS B 2 96  ? 124.135 134.994 87.819  1.00 49.07  ? 96  CYS H CA  1 
ATOM   3993 C C   . CYS B 2 96  ? 123.468 134.212 88.939  1.00 49.07  ? 96  CYS H C   1 
ATOM   3994 O O   . CYS B 2 96  ? 122.402 133.629 88.742  1.00 49.07  ? 96  CYS H O   1 
ATOM   3995 C CB  . CYS B 2 96  ? 123.330 136.238 87.435  1.00 49.07  ? 96  CYS H CB  1 
ATOM   3996 S SG  . CYS B 2 96  ? 121.653 136.056 86.819  1.00 49.07  ? 96  CYS H SG  1 
ATOM   3997 N N   . ALA B 2 97  ? 124.106 134.164 90.104  1.00 47.15  ? 97  ALA H N   1 
ATOM   3998 C CA  . ALA B 2 97  ? 123.690 133.253 91.160  1.00 47.15  ? 97  ALA H CA  1 
ATOM   3999 C C   . ALA B 2 97  ? 123.148 134.005 92.367  1.00 47.15  ? 97  ALA H C   1 
ATOM   4000 O O   . ALA B 2 97  ? 123.771 134.950 92.845  1.00 47.15  ? 97  ALA H O   1 
ATOM   4001 C CB  . ALA B 2 97  ? 124.851 132.355 91.583  1.00 47.15  ? 97  ALA H CB  1 
ATOM   4002 N N   . LEU B 2 98  ? 122.014 133.539 92.891  1.00 46.71  ? 98  LEU H N   1 
ATOM   4003 C CA  . LEU B 2 98  ? 121.288 134.202 93.968  1.00 46.71  ? 98  LEU H CA  1 
ATOM   4004 C C   . LEU B 2 98  ? 121.405 133.404 95.259  1.00 46.71  ? 98  LEU H C   1 
ATOM   4005 O O   . LEU B 2 98  ? 121.120 132.206 95.279  1.00 46.71  ? 98  LEU H O   1 
ATOM   4006 C CB  . LEU B 2 98  ? 119.817 134.390 93.583  1.00 46.71  ? 98  LEU H CB  1 
ATOM   4007 C CG  . LEU B 2 98  ? 118.819 135.122 94.485  1.00 46.71  ? 98  LEU H CG  1 
ATOM   4008 C CD1 . LEU B 2 98  ? 117.882 135.924 93.646  1.00 46.71  ? 98  LEU H CD1 1 
ATOM   4009 C CD2 . LEU B 2 98  ? 117.988 134.143 95.261  1.00 46.71  ? 98  LEU H CD2 1 
ATOM   4010 N N   . ASN B 2 99  ? 121.811 134.078 96.335  1.00 44.97  ? 99  ASN H N   1 
ATOM   4011 C CA  . ASN B 2 99  ? 121.905 133.509 97.668  1.00 44.97  ? 99  ASN H CA  1 
ATOM   4012 C C   . ASN B 2 99  ? 120.706 133.934 98.489  1.00 44.97  ? 99  ASN H C   1 
ATOM   4013 O O   . ASN B 2 99  ? 119.740 134.497 97.982  1.00 44.97  ? 99  ASN H O   1 
ATOM   4014 C CB  . ASN B 2 99  ? 123.131 133.991 98.434  1.00 44.97  ? 99  ASN H CB  1 
ATOM   4015 C CG  . ASN B 2 99  ? 124.399 133.654 97.762  1.00 44.97  ? 99  ASN H CG  1 
ATOM   4016 O OD1 . ASN B 2 99  ? 124.526 132.611 97.138  1.00 44.97  ? 99  ASN H OD1 1 
ATOM   4017 N ND2 . ASN B 2 99  ? 125.381 134.524 97.909  1.00 44.97  ? 99  ASN H ND2 1 
ATOM   4018 N N   . TYR B 2 100 ? 120.792 133.637 99.774  1.00 44.62  ? 100 TYR H N   1 
ATOM   4019 C CA  . TYR B 2 100 ? 120.188 134.433 100.823 1.00 44.62  ? 100 TYR H CA  1 
ATOM   4020 C C   . TYR B 2 100 ? 121.275 134.673 101.850 1.00 44.62  ? 100 TYR H C   1 
ATOM   4021 O O   . TYR B 2 100 ? 122.392 134.178 101.699 1.00 44.62  ? 100 TYR H O   1 
ATOM   4022 C CB  . TYR B 2 100 ? 118.989 133.743 101.451 1.00 44.62  ? 100 TYR H CB  1 
ATOM   4023 C CG  . TYR B 2 100 ? 117.830 133.596 100.512 1.00 44.62  ? 100 TYR H CG  1 
ATOM   4024 C CD1 . TYR B 2 100 ? 117.032 134.676 100.195 1.00 44.62  ? 100 TYR H CD1 1 
ATOM   4025 C CD2 . TYR B 2 100 ? 117.519 132.373 99.962  1.00 44.62  ? 100 TYR H CD2 1 
ATOM   4026 C CE1 . TYR B 2 100 ? 115.970 134.543 99.340  1.00 44.62  ? 100 TYR H CE1 1 
ATOM   4027 C CE2 . TYR B 2 100 ? 116.458 132.232 99.113  1.00 44.62  ? 100 TYR H CE2 1 
ATOM   4028 C CZ  . TYR B 2 100 ? 115.688 133.316 98.807  1.00 44.62  ? 100 TYR H CZ  1 
ATOM   4029 O OH  . TYR B 2 100 ? 114.627 133.169 97.956  1.00 44.62  ? 100 TYR H OH  1 
ATOM   4030 N N   . PHE B 2 101 ? 120.967 135.451 102.877 1.00 43.08  ? 101 PHE H N   1 
ATOM   4031 C CA  . PHE B 2 101 ? 122.020 135.862 103.793 1.00 43.08  ? 101 PHE H CA  1 
ATOM   4032 C C   . PHE B 2 101 ? 122.424 134.704 104.690 1.00 43.08  ? 101 PHE H C   1 
ATOM   4033 O O   . PHE B 2 101 ? 121.587 133.924 105.145 1.00 43.08  ? 101 PHE H O   1 
ATOM   4034 C CB  . PHE B 2 101 ? 121.575 137.052 104.636 1.00 43.08  ? 101 PHE H CB  1 
ATOM   4035 C CG  . PHE B 2 101 ? 122.656 137.599 105.509 1.00 43.08  ? 101 PHE H CG  1 
ATOM   4036 C CD1 . PHE B 2 101 ? 123.655 138.369 104.976 1.00 43.08  ? 101 PHE H CD1 1 
ATOM   4037 C CD2 . PHE B 2 101 ? 122.680 137.332 106.858 1.00 43.08  ? 101 PHE H CD2 1 
ATOM   4038 C CE1 . PHE B 2 101 ? 124.655 138.866 105.770 1.00 43.08  ? 101 PHE H CE1 1 
ATOM   4039 C CE2 . PHE B 2 101 ? 123.684 137.828 107.653 1.00 43.08  ? 101 PHE H CE2 1 
ATOM   4040 C CZ  . PHE B 2 101 ? 124.670 138.598 107.104 1.00 43.08  ? 101 PHE H CZ  1 
ATOM   4041 N N   . GLY B 2 102 ? 123.724 134.580 104.921 1.00 42.43  ? 102 GLY H N   1 
ATOM   4042 C CA  . GLY B 2 102 ? 124.258 133.571 105.796 1.00 42.43  ? 102 GLY H CA  1 
ATOM   4043 C C   . GLY B 2 102 ? 124.522 132.234 105.146 1.00 42.43  ? 102 GLY H C   1 
ATOM   4044 O O   . GLY B 2 102 ? 125.448 131.538 105.561 1.00 42.43  ? 102 GLY H O   1 
ATOM   4045 N N   . SER B 2 103 ? 123.747 131.858 104.134 1.00 41.38  ? 103 SER H N   1 
ATOM   4046 C CA  . SER B 2 103 ? 123.911 130.592 103.429 1.00 41.38  ? 103 SER H CA  1 
ATOM   4047 C C   . SER B 2 103 ? 124.403 130.921 102.032 1.00 41.38  ? 103 SER H C   1 
ATOM   4048 O O   . SER B 2 103 ? 123.612 131.279 101.161 1.00 41.38  ? 103 SER H O   1 
ATOM   4049 C CB  . SER B 2 103 ? 122.605 129.823 103.377 1.00 41.38  ? 103 SER H CB  1 
ATOM   4050 O OG  . SER B 2 103 ? 121.666 130.489 102.557 1.00 41.38  ? 103 SER H OG  1 
ATOM   4051 N N   . ARG B 2 104 ? 125.702 130.783 101.815 1.00 39.33  ? 104 ARG H N   1 
ATOM   4052 C CA  . ARG B 2 104 ? 126.331 131.199 100.567 1.00 39.33  ? 104 ARG H CA  1 
ATOM   4053 C C   . ARG B 2 104 ? 126.413 130.038 99.572  1.00 39.33  ? 104 ARG H C   1 
ATOM   4054 O O   . ARG B 2 104 ? 127.450 129.736 98.998  1.00 39.33  ? 104 ARG H O   1 
ATOM   4055 C CB  . ARG B 2 104 ? 127.698 131.782 100.876 1.00 39.33  ? 104 ARG H CB  1 
ATOM   4056 C CG  . ARG B 2 104 ? 127.603 133.025 101.704 1.00 39.33  ? 104 ARG H CG  1 
ATOM   4057 C CD  . ARG B 2 104 ? 128.942 133.478 102.206 1.00 39.33  ? 104 ARG H CD  1 
ATOM   4058 N NE  . ARG B 2 104 ? 129.425 132.651 103.295 1.00 39.33  ? 104 ARG H NE  1 
ATOM   4059 C CZ  . ARG B 2 104 ? 130.604 132.805 103.875 1.00 39.33  ? 104 ARG H CZ  1 
ATOM   4060 N NH1 . ARG B 2 104 ? 131.419 133.752 103.469 1.00 39.33  ? 104 ARG H NH1 1 
ATOM   4061 N NH2 . ARG B 2 104 ? 130.966 132.017 104.865 1.00 39.33  ? 104 ARG H NH2 1 
ATOM   4062 N N   . LYS B 2 105 ? 125.276 129.393 99.367  1.00 40.30  ? 105 LYS H N   1 
ATOM   4063 C CA  . LYS B 2 105 ? 125.088 128.397 98.328  1.00 40.30  ? 105 LYS H CA  1 
ATOM   4064 C C   . LYS B 2 105 ? 124.209 129.006 97.255  1.00 40.30  ? 105 LYS H C   1 
ATOM   4065 O O   . LYS B 2 105 ? 123.469 129.956 97.518  1.00 40.30  ? 105 LYS H O   1 
ATOM   4066 C CB  . LYS B 2 105 ? 124.447 127.141 98.882  1.00 40.30  ? 105 LYS H CB  1 
ATOM   4067 C CG  . LYS B 2 105 ? 123.061 127.362 99.401  1.00 40.30  ? 105 LYS H CG  1 
ATOM   4068 C CD  . LYS B 2 105 ? 122.511 126.142 100.056 1.00 40.30  ? 105 LYS H CD  1 
ATOM   4069 C CE  . LYS B 2 105 ? 121.089 126.396 100.486 1.00 40.30  ? 105 LYS H CE  1 
ATOM   4070 N NZ  . LYS B 2 105 ? 121.016 127.471 101.497 1.00 40.30  ? 105 LYS H NZ  1 
ATOM   4071 N N   . PHE B 2 106 ? 124.281 128.466 96.046  1.00 41.02  ? 106 PHE H N   1 
ATOM   4072 C CA  . PHE B 2 106 ? 123.702 129.130 94.879  1.00 41.02  ? 106 PHE H CA  1 
ATOM   4073 C C   . PHE B 2 106 ? 122.353 128.503 94.624  1.00 41.02  ? 106 PHE H C   1 
ATOM   4074 O O   . PHE B 2 106 ? 122.252 127.473 93.961  1.00 41.02  ? 106 PHE H O   1 
ATOM   4075 C CB  . PHE B 2 106 ? 124.610 128.999 93.670  1.00 41.02  ? 106 PHE H CB  1 
ATOM   4076 C CG  . PHE B 2 106 ? 125.921 129.685 93.834  1.00 41.02  ? 106 PHE H CG  1 
ATOM   4077 C CD1 . PHE B 2 106 ? 126.062 130.742 94.697  1.00 41.02  ? 106 PHE H CD1 1 
ATOM   4078 C CD2 . PHE B 2 106 ? 127.027 129.222 93.176  1.00 41.02  ? 106 PHE H CD2 1 
ATOM   4079 C CE1 . PHE B 2 106 ? 127.266 131.337 94.874  1.00 41.02  ? 106 PHE H CE1 1 
ATOM   4080 C CE2 . PHE B 2 106 ? 128.237 129.826 93.351  1.00 41.02  ? 106 PHE H CE2 1 
ATOM   4081 C CZ  . PHE B 2 106 ? 128.352 130.886 94.198  1.00 41.02  ? 106 PHE H CZ  1 
ATOM   4082 N N   . ASP B 2 107 ? 121.315 129.129 95.156  1.00 44.23  ? 107 ASP H N   1 
ATOM   4083 C CA  . ASP B 2 107 ? 119.989 128.544 95.085  1.00 44.23  ? 107 ASP H CA  1 
ATOM   4084 C C   . ASP B 2 107 ? 119.407 128.669 93.691  1.00 44.23  ? 107 ASP H C   1 
ATOM   4085 O O   . ASP B 2 107 ? 118.752 127.743 93.204  1.00 44.23  ? 107 ASP H O   1 
ATOM   4086 C CB  . ASP B 2 107 ? 119.088 129.222 96.102  1.00 44.23  ? 107 ASP H CB  1 
ATOM   4087 C CG  . ASP B 2 107 ? 119.549 128.993 97.508  1.00 44.23  ? 107 ASP H CG  1 
ATOM   4088 O OD1 . ASP B 2 107 ? 120.140 127.927 97.758  1.00 44.23  ? 107 ASP H OD1 1 
ATOM   4089 O OD2 . ASP B 2 107 ? 119.339 129.881 98.356  1.00 44.23  ? 107 ASP H OD2 1 
ATOM   4090 N N   . TYR B 2 108 ? 119.642 129.797 93.032  1.00 47.12  ? 108 TYR H N   1 
ATOM   4091 C CA  . TYR B 2 108 ? 119.064 130.077 91.730  1.00 47.12  ? 108 TYR H CA  1 
ATOM   4092 C C   . TYR B 2 108 ? 120.130 130.620 90.791  1.00 47.12  ? 108 TYR H C   1 
ATOM   4093 O O   . TYR B 2 108 ? 121.052 131.321 91.212  1.00 47.12  ? 108 TYR H O   1 
ATOM   4094 C CB  . TYR B 2 108 ? 117.900 131.051 91.859  1.00 47.12  ? 108 TYR H CB  1 
ATOM   4095 C CG  . TYR B 2 108 ? 116.747 130.450 92.622  1.00 47.12  ? 108 TYR H CG  1 
ATOM   4096 C CD1 . TYR B 2 108 ? 115.858 129.588 91.999  1.00 47.12  ? 108 TYR H CD1 1 
ATOM   4097 C CD2 . TYR B 2 108 ? 116.563 130.724 93.965  1.00 47.12  ? 108 TYR H CD2 1 
ATOM   4098 C CE1 . TYR B 2 108 ? 114.815 129.026 92.685  1.00 47.12  ? 108 TYR H CE1 1 
ATOM   4099 C CE2 . TYR B 2 108 ? 115.519 130.165 94.663  1.00 47.12  ? 108 TYR H CE2 1 
ATOM   4100 C CZ  . TYR B 2 108 ? 114.648 129.317 94.015  1.00 47.12  ? 108 TYR H CZ  1 
ATOM   4101 O OH  . TYR B 2 108 ? 113.600 128.753 94.702  1.00 47.12  ? 108 TYR H OH  1 
ATOM   4102 N N   . TRP B 2 109 ? 119.987 130.277 89.508  1.00 43.58  ? 109 TRP H N   1 
ATOM   4103 C CA  . TRP B 2 109 ? 121.003 130.489 88.482  1.00 43.58  ? 109 TRP H CA  1 
ATOM   4104 C C   . TRP B 2 109 ? 120.511 131.234 87.256  1.00 43.58  ? 109 TRP H C   1 
ATOM   4105 O O   . TRP B 2 109 ? 121.229 132.076 86.722  1.00 43.58  ? 109 TRP H O   1 
ATOM   4106 C CB  . TRP B 2 109 ? 121.547 129.137 88.029  1.00 43.58  ? 109 TRP H CB  1 
ATOM   4107 C CG  . TRP B 2 109 ? 122.344 128.446 89.040  1.00 43.58  ? 109 TRP H CG  1 
ATOM   4108 C CD1 . TRP B 2 109 ? 121.881 127.657 90.026  1.00 43.58  ? 109 TRP H CD1 1 
ATOM   4109 C CD2 . TRP B 2 109 ? 123.757 128.426 89.136  1.00 43.58  ? 109 TRP H CD2 1 
ATOM   4110 N NE1 . TRP B 2 109 ? 122.919 127.164 90.758  1.00 43.58  ? 109 TRP H NE1 1 
ATOM   4111 C CE2 . TRP B 2 109 ? 124.087 127.626 90.223  1.00 43.58  ? 109 TRP H CE2 1 
ATOM   4112 C CE3 . TRP B 2 109 ? 124.775 129.021 88.412  1.00 43.58  ? 109 TRP H CE3 1 
ATOM   4113 C CZ2 . TRP B 2 109 ? 125.392 127.397 90.600  1.00 43.58  ? 109 TRP H CZ2 1 
ATOM   4114 C CZ3 . TRP B 2 109 ? 126.057 128.793 88.788  1.00 43.58  ? 109 TRP H CZ3 1 
ATOM   4115 C CH2 . TRP B 2 109 ? 126.361 128.001 89.875  1.00 43.58  ? 109 TRP H CH2 1 
ATOM   4116 N N   . GLY B 2 110 ? 119.325 130.918 86.759  1.00 48.46  ? 110 GLY H N   1 
ATOM   4117 C CA  . GLY B 2 110 ? 118.898 131.479 85.492  1.00 48.46  ? 110 GLY H CA  1 
ATOM   4118 C C   . GLY B 2 110 ? 119.650 130.962 84.278  1.00 48.46  ? 110 GLY H C   1 
ATOM   4119 O O   . GLY B 2 110 ? 120.483 130.057 84.383  1.00 48.46  ? 110 GLY H O   1 
ATOM   4120 N N   . GLN B 2 111 ? 119.359 131.539 83.114  1.00 50.59  ? 111 GLN H N   1 
ATOM   4121 C CA  . GLN B 2 111 ? 120.036 131.196 81.875  1.00 50.59  ? 111 GLN H CA  1 
ATOM   4122 C C   . GLN B 2 111 ? 121.458 131.744 81.873  1.00 50.59  ? 111 GLN H C   1 
ATOM   4123 O O   . GLN B 2 111 ? 121.933 132.339 82.839  1.00 50.59  ? 111 GLN H O   1 
ATOM   4124 C CB  . GLN B 2 111 ? 119.276 131.768 80.692  1.00 50.59  ? 111 GLN H CB  1 
ATOM   4125 C CG  . GLN B 2 111 ? 119.223 133.284 80.740  1.00 50.59  ? 111 GLN H CG  1 
ATOM   4126 C CD  . GLN B 2 111 ? 118.441 133.893 79.606  1.00 50.59  ? 111 GLN H CD  1 
ATOM   4127 O OE1 . GLN B 2 111 ? 117.949 133.190 78.727  1.00 50.59  ? 111 GLN H OE1 1 
ATOM   4128 N NE2 . GLN B 2 111 ? 118.327 135.211 79.613  1.00 50.59  ? 111 GLN H NE2 1 
ATOM   4129 N N   . GLY B 2 112 ? 122.138 131.541 80.770  1.00 48.55  ? 112 GLY H N   1 
ATOM   4130 C CA  . GLY B 2 112 ? 123.461 132.100 80.615  1.00 48.55  ? 112 GLY H CA  1 
ATOM   4131 C C   . GLY B 2 112 ? 123.510 133.173 79.571  1.00 48.55  ? 112 GLY H C   1 
ATOM   4132 O O   . GLY B 2 112 ? 122.570 133.375 78.814  1.00 48.55  ? 112 GLY H O   1 
ATOM   4133 N N   . THR B 2 113 ? 124.632 133.880 79.539  1.00 49.68  ? 113 THR H N   1 
ATOM   4134 C CA  . THR B 2 113 ? 124.926 134.806 78.459  1.00 49.68  ? 113 THR H CA  1 
ATOM   4135 C C   . THR B 2 113 ? 126.304 134.463 77.926  1.00 49.68  ? 113 THR H C   1 
ATOM   4136 O O   . THR B 2 113 ? 127.183 134.061 78.688  1.00 49.68  ? 113 THR H O   1 
ATOM   4137 C CB  . THR B 2 113 ? 124.832 136.279 78.908  1.00 49.68  ? 113 THR H CB  1 
ATOM   4138 O OG1 . THR B 2 113 ? 125.002 137.140 77.777  1.00 49.68  ? 113 THR H OG1 1 
ATOM   4139 C CG2 . THR B 2 113 ? 125.858 136.648 79.972  1.00 49.68  ? 113 THR H CG2 1 
ATOM   4140 N N   . THR B 2 114 ? 126.478 134.557 76.617  1.00 49.19  ? 114 THR H N   1 
ATOM   4141 C CA  . THR B 2 114 ? 127.691 134.076 75.972  1.00 49.19  ? 114 THR H CA  1 
ATOM   4142 C C   . THR B 2 114 ? 128.504 135.280 75.530  1.00 49.19  ? 114 THR H C   1 
ATOM   4143 O O   . THR B 2 114 ? 128.069 136.073 74.705  1.00 49.19  ? 114 THR H O   1 
ATOM   4144 C CB  . THR B 2 114 ? 127.342 133.170 74.805  1.00 49.19  ? 114 THR H CB  1 
ATOM   4145 O OG1 . THR B 2 114 ? 126.537 132.088 75.279  1.00 49.19  ? 114 THR H OG1 1 
ATOM   4146 C CG2 . THR B 2 114 ? 128.601 132.606 74.176  1.00 49.19  ? 114 THR H CG2 1 
ATOM   4147 N N   . VAL B 2 115 ? 129.695 135.417 76.084  1.00 50.10  ? 115 VAL H N   1 
ATOM   4148 C CA  . VAL B 2 115 ? 130.586 136.501 75.700  1.00 50.10  ? 115 VAL H CA  1 
ATOM   4149 C C   . VAL B 2 115 ? 131.701 135.947 74.827  1.00 50.10  ? 115 VAL H C   1 
ATOM   4150 O O   . VAL B 2 115 ? 132.413 135.021 75.224  1.00 50.10  ? 115 VAL H O   1 
ATOM   4151 C CB  . VAL B 2 115 ? 131.149 137.205 76.943  1.00 50.10  ? 115 VAL H CB  1 
ATOM   4152 C CG1 . VAL B 2 115 ? 132.184 138.227 76.552  1.00 50.10  ? 115 VAL H CG1 1 
ATOM   4153 C CG2 . VAL B 2 115 ? 130.039 137.877 77.711  1.00 50.10  ? 115 VAL H CG2 1 
ATOM   4154 N N   . THR B 2 116 ? 131.850 136.507 73.633  1.00 52.66  ? 116 THR H N   1 
ATOM   4155 C CA  . THR B 2 116 ? 132.922 136.191 72.703  1.00 52.66  ? 116 THR H CA  1 
ATOM   4156 C C   . THR B 2 116 ? 133.830 137.409 72.624  1.00 52.66  ? 116 THR H C   1 
ATOM   4157 O O   . THR B 2 116 ? 133.389 138.531 72.861  1.00 52.66  ? 116 THR H O   1 
ATOM   4158 C CB  . THR B 2 116 ? 132.337 135.847 71.328  1.00 52.66  ? 116 THR H CB  1 
ATOM   4159 O OG1 . THR B 2 116 ? 131.247 134.937 71.502  1.00 52.66  ? 116 THR H OG1 1 
ATOM   4160 C CG2 . THR B 2 116 ? 133.360 135.161 70.434  1.00 52.66  ? 116 THR H CG2 1 
ATOM   4161 N N   . VAL B 2 117 ? 135.112 137.209 72.323  1.00 55.80  ? 117 VAL H N   1 
ATOM   4162 C CA  . VAL B 2 117 ? 136.011 138.357 72.386  1.00 55.80  ? 117 VAL H CA  1 
ATOM   4163 C C   . VAL B 2 117 ? 136.634 138.751 71.042  1.00 55.80  ? 117 VAL H C   1 
ATOM   4164 O O   . VAL B 2 117 ? 136.318 139.814 70.500  1.00 55.80  ? 117 VAL H O   1 
ATOM   4165 C CB  . VAL B 2 117 ? 137.105 138.126 73.441  1.00 55.80  ? 117 VAL H CB  1 
ATOM   4166 C CG1 . VAL B 2 117 ? 138.063 139.287 73.461  1.00 55.80  ? 117 VAL H CG1 1 
ATOM   4167 C CG2 . VAL B 2 117 ? 136.484 137.982 74.803  1.00 55.80  ? 117 VAL H CG2 1 
ATOM   4168 N N   . SER B 2 118 ? 137.489 137.910 70.469  1.00 59.67  ? 118 SER H N   1 
ATOM   4169 C CA  . SER B 2 118 ? 138.484 138.381 69.508  1.00 59.67  ? 118 SER H CA  1 
ATOM   4170 C C   . SER B 2 118 ? 137.907 138.622 68.116  1.00 59.67  ? 118 SER H C   1 
ATOM   4171 O O   . SER B 2 118 ? 137.263 137.742 67.537  1.00 59.67  ? 118 SER H O   1 
ATOM   4172 C CB  . SER B 2 118 ? 139.642 137.388 69.407  1.00 59.67  ? 118 SER H CB  1 
ATOM   4173 O OG  . SER B 2 118 ? 140.601 137.831 68.461  1.00 59.67  ? 118 SER H OG  1 
ATOM   4174 N N   . SER B 2 119 ? 138.148 139.831 67.597  1.00 60.59  ? 119 SER H N   1 
ATOM   4175 C CA  . SER B 2 119 ? 137.991 140.212 66.182  1.00 60.59  ? 119 SER H CA  1 
ATOM   4176 C C   . SER B 2 119 ? 136.631 139.976 65.533  1.00 60.59  ? 119 SER H C   1 
ATOM   4177 O O   . SER B 2 119 ? 136.518 139.922 64.310  1.00 60.59  ? 119 SER H O   1 
ATOM   4178 C CB  . SER B 2 119 ? 139.049 139.503 65.357  1.00 60.59  ? 119 SER H CB  1 
ATOM   4179 O OG  . SER B 2 119 ? 140.334 139.936 65.755  1.00 60.59  ? 119 SER H OG  1 
ATOM   4180 O OXT . SER B 2 119 ? 135.614 139.843 66.207  1.00 60.59  ? 119 SER H OXT 1 
ATOM   4181 N N   . GLU C 3 1   ? 142.239 131.373 99.959  1.00 50.86  ? 1   GLU L N   1 
ATOM   4182 C CA  . GLU C 3 1   ? 141.969 130.465 98.853  1.00 50.86  ? 1   GLU L CA  1 
ATOM   4183 C C   . GLU C 3 1   ? 141.960 129.022 99.311  1.00 50.86  ? 1   GLU L C   1 
ATOM   4184 O O   . GLU C 3 1   ? 142.991 128.472 99.681  1.00 50.86  ? 1   GLU L O   1 
ATOM   4185 C CB  . GLU C 3 1   ? 142.999 130.644 97.744  1.00 50.86  ? 1   GLU L CB  1 
ATOM   4186 C CG  . GLU C 3 1   ? 142.805 129.702 96.571  1.00 50.86  ? 1   GLU L CG  1 
ATOM   4187 C CD  . GLU C 3 1   ? 141.537 129.977 95.789  1.00 50.86  ? 1   GLU L CD  1 
ATOM   4188 O OE1 . GLU C 3 1   ? 141.090 131.143 95.754  1.00 50.86  ? 1   GLU L OE1 1 
ATOM   4189 O OE2 . GLU C 3 1   ? 140.985 129.018 95.208  1.00 50.86  ? 1   GLU L OE2 1 
ATOM   4190 N N   . ILE C 3 2   ? 140.784 128.414 99.285  1.00 47.57  ? 2   ILE L N   1 
ATOM   4191 C CA  . ILE C 3 2   ? 140.605 127.025 99.672  1.00 47.57  ? 2   ILE L CA  1 
ATOM   4192 C C   . ILE C 3 2   ? 140.496 126.212 98.395  1.00 47.57  ? 2   ILE L C   1 
ATOM   4193 O O   . ILE C 3 2   ? 139.478 126.266 97.700  1.00 47.57  ? 2   ILE L O   1 
ATOM   4194 C CB  . ILE C 3 2   ? 139.368 126.843 100.552 1.00 47.57  ? 2   ILE L CB  1 
ATOM   4195 C CG1 . ILE C 3 2   ? 139.500 127.682 101.817 1.00 47.57  ? 2   ILE L CG1 1 
ATOM   4196 C CG2 . ILE C 3 2   ? 139.206 125.388 100.913 1.00 47.57  ? 2   ILE L CG2 1 
ATOM   4197 C CD1 . ILE C 3 2   ? 138.232 127.785 102.615 1.00 47.57  ? 2   ILE L CD1 1 
ATOM   4198 N N   . VAL C 3 3   ? 141.545 125.461 98.078  1.00 45.44  ? 3   VAL L N   1 
ATOM   4199 C CA  . VAL C 3 3   ? 141.584 124.665 96.859  1.00 45.44  ? 3   VAL L CA  1 
ATOM   4200 C C   . VAL C 3 3   ? 140.820 123.375 97.101  1.00 45.44  ? 3   VAL L C   1 
ATOM   4201 O O   . VAL C 3 3   ? 141.073 122.665 98.075  1.00 45.44  ? 3   VAL L O   1 
ATOM   4202 C CB  . VAL C 3 3   ? 143.031 124.383 96.435  1.00 45.44  ? 3   VAL L CB  1 
ATOM   4203 C CG1 . VAL C 3 3   ? 143.073 123.484 95.212  1.00 45.44  ? 3   VAL L CG1 1 
ATOM   4204 C CG2 . VAL C 3 3   ? 143.756 125.685 96.162  1.00 45.44  ? 3   VAL L CG2 1 
ATOM   4205 N N   . LEU C 3 4   ? 139.879 123.075 96.228  1.00 43.36  ? 4   LEU L N   1 
ATOM   4206 C CA  . LEU C 3 4   ? 139.071 121.873 96.337  1.00 43.36  ? 4   LEU L CA  1 
ATOM   4207 C C   . LEU C 3 4   ? 139.491 120.906 95.243  1.00 43.36  ? 4   LEU L C   1 
ATOM   4208 O O   . LEU C 3 4   ? 139.253 121.163 94.059  1.00 43.36  ? 4   LEU L O   1 
ATOM   4209 C CB  . LEU C 3 4   ? 137.587 122.202 96.222  1.00 43.36  ? 4   LEU L CB  1 
ATOM   4210 C CG  . LEU C 3 4   ? 136.789 122.538 97.473  1.00 43.36  ? 4   LEU L CG  1 
ATOM   4211 C CD1 . LEU C 3 4   ? 137.278 123.777 98.119  1.00 43.36  ? 4   LEU L CD1 1 
ATOM   4212 C CD2 . LEU C 3 4   ? 135.377 122.742 97.074  1.00 43.36  ? 4   LEU L CD2 1 
ATOM   4213 N N   . THR C 3 5   ? 140.118 119.803 95.636  1.00 45.37  ? 5   THR L N   1 
ATOM   4214 C CA  . THR C 3 5   ? 140.590 118.795 94.700  1.00 45.37  ? 5   THR L CA  1 
ATOM   4215 C C   . THR C 3 5   ? 139.587 117.659 94.663  1.00 45.37  ? 5   THR L C   1 
ATOM   4216 O O   . THR C 3 5   ? 139.221 117.113 95.703  1.00 45.37  ? 5   THR L O   1 
ATOM   4217 C CB  . THR C 3 5   ? 141.973 118.286 95.083  1.00 45.37  ? 5   THR L CB  1 
ATOM   4218 O OG1 . THR C 3 5   ? 141.924 117.744 96.404  1.00 45.37  ? 5   THR L OG1 1 
ATOM   4219 C CG2 . THR C 3 5   ? 142.981 119.414 95.034  1.00 45.37  ? 5   THR L CG2 1 
ATOM   4220 N N   . GLN C 3 6   ? 139.155 117.310 93.467  1.00 44.28  ? 6   GLN L N   1 
ATOM   4221 C CA  . GLN C 3 6   ? 138.073 116.376 93.249  1.00 44.28  ? 6   GLN L CA  1 
ATOM   4222 C C   . GLN C 3 6   ? 138.559 115.257 92.339  1.00 44.28  ? 6   GLN L C   1 
ATOM   4223 O O   . GLN C 3 6   ? 139.242 115.499 91.342  1.00 44.28  ? 6   GLN L O   1 
ATOM   4224 C CB  . GLN C 3 6   ? 136.882 117.122 92.647  1.00 44.28  ? 6   GLN L CB  1 
ATOM   4225 C CG  . GLN C 3 6   ? 135.611 116.351 92.442  1.00 44.28  ? 6   GLN L CG  1 
ATOM   4226 C CD  . GLN C 3 6   ? 134.481 117.270 92.054  1.00 44.28  ? 6   GLN L CD  1 
ATOM   4227 O OE1 . GLN C 3 6   ? 134.661 118.475 91.963  1.00 44.28  ? 6   GLN L OE1 1 
ATOM   4228 N NE2 . GLN C 3 6   ? 133.312 116.706 91.820  1.00 44.28  ? 6   GLN L NE2 1 
ATOM   4229 N N   . SER C 3 7   ? 138.223 114.019 92.706  1.00 45.05  ? 7   SER L N   1 
ATOM   4230 C CA  . SER C 3 7   ? 138.738 112.858 92.016  1.00 45.05  ? 7   SER L CA  1 
ATOM   4231 C C   . SER C 3 7   ? 137.611 111.858 91.846  1.00 45.05  ? 7   SER L C   1 
ATOM   4232 O O   . SER C 3 7   ? 136.802 111.699 92.767  1.00 45.05  ? 7   SER L O   1 
ATOM   4233 C CB  . SER C 3 7   ? 139.879 112.205 92.784  1.00 45.05  ? 7   SER L CB  1 
ATOM   4234 O OG  . SER C 3 7   ? 139.387 111.601 93.961  1.00 45.05  ? 7   SER L OG  1 
ATOM   4235 N N   . PRO C 3 8   ? 137.530 111.160 90.704  1.00 48.53  ? 8   PRO L N   1 
ATOM   4236 C CA  . PRO C 3 8   ? 138.404 111.219 89.529  1.00 48.53  ? 8   PRO L CA  1 
ATOM   4237 C C   . PRO C 3 8   ? 138.069 112.386 88.613  1.00 48.53  ? 8   PRO L C   1 
ATOM   4238 O O   . PRO C 3 8   ? 137.103 113.099 88.866  1.00 48.53  ? 8   PRO L O   1 
ATOM   4239 C CB  . PRO C 3 8   ? 138.118 109.899 88.832  1.00 48.53  ? 8   PRO L CB  1 
ATOM   4240 C CG  . PRO C 3 8   ? 136.716 109.613 89.181  1.00 48.53  ? 8   PRO L CG  1 
ATOM   4241 C CD  . PRO C 3 8   ? 136.513 110.106 90.566  1.00 48.53  ? 8   PRO L CD  1 
ATOM   4242 N N   . ALA C 3 9   ? 138.864 112.592 87.567  1.00 49.23  ? 9   ALA L N   1 
ATOM   4243 C CA  . ALA C 3 9   ? 138.524 113.630 86.607  1.00 49.23  ? 9   ALA L CA  1 
ATOM   4244 C C   . ALA C 3 9   ? 137.367 113.188 85.729  1.00 49.23  ? 9   ALA L C   1 
ATOM   4245 O O   . ALA C 3 9   ? 136.459 113.972 85.444  1.00 49.23  ? 9   ALA L O   1 
ATOM   4246 C CB  . ALA C 3 9   ? 139.742 113.982 85.760  1.00 49.23  ? 9   ALA L CB  1 
ATOM   4247 N N   . THR C 3 10  ? 137.388 111.939 85.283  1.00 51.09  ? 10  THR L N   1 
ATOM   4248 C CA  . THR C 3 10  ? 136.272 111.352 84.566  1.00 51.09  ? 10  THR L CA  1 
ATOM   4249 C C   . THR C 3 10  ? 135.995 109.987 85.161  1.00 51.09  ? 10  THR L C   1 
ATOM   4250 O O   . THR C 3 10  ? 136.843 109.398 85.829  1.00 51.09  ? 10  THR L O   1 
ATOM   4251 C CB  . THR C 3 10  ? 136.535 111.238 83.062  1.00 51.09  ? 10  THR L CB  1 
ATOM   4252 O OG1 . THR C 3 10  ? 135.359 110.741 82.411  1.00 51.09  ? 10  THR L OG1 1 
ATOM   4253 C CG2 . THR C 3 10  ? 137.707 110.312 82.780  1.00 51.09  ? 10  THR L CG2 1 
ATOM   4254 N N   . LEU C 3 11  ? 134.793 109.484 84.919  1.00 51.65  ? 11  LEU L N   1 
ATOM   4255 C CA  . LEU C 3 11  ? 134.317 108.309 85.636  1.00 51.65  ? 11  LEU L CA  1 
ATOM   4256 C C   . LEU C 3 11  ? 133.310 107.593 84.757  1.00 51.65  ? 11  LEU L C   1 
ATOM   4257 O O   . LEU C 3 11  ? 132.142 107.979 84.712  1.00 51.65  ? 11  LEU L O   1 
ATOM   4258 C CB  . LEU C 3 11  ? 133.706 108.722 86.968  1.00 51.65  ? 11  LEU L CB  1 
ATOM   4259 C CG  . LEU C 3 11  ? 133.288 107.642 87.945  1.00 51.65  ? 11  LEU L CG  1 
ATOM   4260 C CD1 . LEU C 3 11  ? 134.479 106.791 88.321  1.00 51.65  ? 11  LEU L CD1 1 
ATOM   4261 C CD2 . LEU C 3 11  ? 132.670 108.268 89.179  1.00 51.65  ? 11  LEU L CD2 1 
ATOM   4262 N N   . SER C 3 12  ? 133.758 106.545 84.075  1.00 54.19  ? 12  SER L N   1 
ATOM   4263 C CA  . SER C 3 12  ? 132.961 105.875 83.055  1.00 54.19  ? 12  SER L CA  1 
ATOM   4264 C C   . SER C 3 12  ? 132.263 104.673 83.672  1.00 54.19  ? 12  SER L C   1 
ATOM   4265 O O   . SER C 3 12  ? 132.917 103.713 84.082  1.00 54.19  ? 12  SER L O   1 
ATOM   4266 C CB  . SER C 3 12  ? 133.848 105.457 81.891  1.00 54.19  ? 12  SER L CB  1 
ATOM   4267 O OG  . SER C 3 12  ? 134.433 106.591 81.277  1.00 54.19  ? 12  SER L OG  1 
ATOM   4268 N N   . LEU C 3 13  ? 130.940 104.724 83.742  1.00 54.88  ? 13  LEU L N   1 
ATOM   4269 C CA  . LEU C 3 13  ? 130.158 103.660 84.341  1.00 54.88  ? 13  LEU L CA  1 
ATOM   4270 C C   . LEU C 3 13  ? 129.008 103.282 83.429  1.00 54.88  ? 13  LEU L C   1 
ATOM   4271 O O   . LEU C 3 13  ? 128.836 103.833 82.342  1.00 54.88  ? 13  LEU L O   1 
ATOM   4272 C CB  . LEU C 3 13  ? 129.613 104.053 85.714  1.00 54.88  ? 13  LEU L CB  1 
ATOM   4273 C CG  . LEU C 3 13  ? 130.376 103.715 86.991  1.00 54.88  ? 13  LEU L CG  1 
ATOM   4274 C CD1 . LEU C 3 13  ? 131.627 104.503 87.134  1.00 54.88  ? 13  LEU L CD1 1 
ATOM   4275 C CD2 . LEU C 3 13  ? 129.479 103.949 88.180  1.00 54.88  ? 13  LEU L CD2 1 
ATOM   4276 N N   . SER C 3 14  ? 128.216 102.332 83.898  1.00 55.26  ? 14  SER L N   1 
ATOM   4277 C CA  . SER C 3 14  ? 127.084 101.738 83.217  1.00 55.26  ? 14  SER L CA  1 
ATOM   4278 C C   . SER C 3 14  ? 125.786 102.217 83.833  1.00 55.26  ? 14  SER L C   1 
ATOM   4279 O O   . SER C 3 14  ? 125.754 102.606 84.999  1.00 55.26  ? 14  SER L O   1 
ATOM   4280 C CB  . SER C 3 14  ? 127.164 100.211 83.305  1.00 55.26  ? 14  SER L CB  1 
ATOM   4281 O OG  . SER C 3 14  ? 128.300 99.712  82.621  1.00 55.26  ? 14  SER L OG  1 
ATOM   4282 N N   . PRO C 3 15  ? 124.694 102.229 83.073  1.00 56.51  ? 15  PRO L N   1 
ATOM   4283 C CA  . PRO C 3 15  ? 123.408 102.650 83.642  1.00 56.51  ? 15  PRO L CA  1 
ATOM   4284 C C   . PRO C 3 15  ? 122.850 101.610 84.600  1.00 56.51  ? 15  PRO L C   1 
ATOM   4285 O O   . PRO C 3 15  ? 122.769 100.424 84.274  1.00 56.51  ? 15  PRO L O   1 
ATOM   4286 C CB  . PRO C 3 15  ? 122.512 102.809 82.413  1.00 56.51  ? 15  PRO L CB  1 
ATOM   4287 C CG  . PRO C 3 15  ? 123.450 103.038 81.300  1.00 56.51  ? 15  PRO L CG  1 
ATOM   4288 C CD  . PRO C 3 15  ? 124.645 102.200 81.606  1.00 56.51  ? 15  PRO L CD  1 
ATOM   4289 N N   . GLY C 3 16  ? 122.450 102.069 85.783  1.00 56.95  ? 16  GLY L N   1 
ATOM   4290 C CA  . GLY C 3 16  ? 121.930 101.205 86.818  1.00 56.95  ? 16  GLY L CA  1 
ATOM   4291 C C   . GLY C 3 16  ? 122.902 100.885 87.930  1.00 56.95  ? 16  GLY L C   1 
ATOM   4292 O O   . GLY C 3 16  ? 122.484 100.329 88.950  1.00 56.95  ? 16  GLY L O   1 
ATOM   4293 N N   . GLU C 3 17  ? 124.171 101.230 87.779  1.00 57.46  ? 17  GLU L N   1 
ATOM   4294 C CA  . GLU C 3 17  ? 125.176 100.915 88.774  1.00 57.46  ? 17  GLU L CA  1 
ATOM   4295 C C   . GLU C 3 17  ? 125.155 101.935 89.907  1.00 57.46  ? 17  GLU L C   1 
ATOM   4296 O O   . GLU C 3 17  ? 124.239 102.745 90.035  1.00 57.46  ? 17  GLU L O   1 
ATOM   4297 C CB  . GLU C 3 17  ? 126.551 100.864 88.124  1.00 57.46  ? 17  GLU L CB  1 
ATOM   4298 C CG  . GLU C 3 17  ? 126.718 99.734  87.129  1.00 57.46  ? 17  GLU L CG  1 
ATOM   4299 C CD  . GLU C 3 17  ? 126.746 98.365  87.788  1.00 57.46  ? 17  GLU L CD  1 
ATOM   4300 O OE1 . GLU C 3 17  ? 127.231 98.262  88.935  1.00 57.46  ? 17  GLU L OE1 1 
ATOM   4301 O OE2 . GLU C 3 17  ? 126.286 97.390  87.156  1.00 57.46  ? 17  GLU L OE2 1 
ATOM   4302 N N   . ARG C 3 18  ? 126.178 101.879 90.751  1.00 55.25  ? 18  ARG L N   1 
ATOM   4303 C CA  . ARG C 3 18  ? 126.345 102.856 91.814  1.00 55.25  ? 18  ARG L CA  1 
ATOM   4304 C C   . ARG C 3 18  ? 127.660 103.596 91.634  1.00 55.25  ? 18  ARG L C   1 
ATOM   4305 O O   . ARG C 3 18  ? 128.686 102.987 91.323  1.00 55.25  ? 18  ARG L O   1 
ATOM   4306 C CB  . ARG C 3 18  ? 126.307 102.178 93.181  1.00 55.25  ? 18  ARG L CB  1 
ATOM   4307 N N   . ALA C 3 19  ? 127.627 104.913 91.843  1.00 52.20  ? 19  ALA L N   1 
ATOM   4308 C CA  . ALA C 3 19  ? 128.777 105.777 91.617  1.00 52.20  ? 19  ALA L CA  1 
ATOM   4309 C C   . ALA C 3 19  ? 129.104 106.562 92.873  1.00 52.20  ? 19  ALA L C   1 
ATOM   4310 O O   . ALA C 3 19  ? 128.206 106.988 93.598  1.00 52.20  ? 19  ALA L O   1 
ATOM   4311 C CB  . ALA C 3 19  ? 128.524 106.753 90.472  1.00 52.20  ? 19  ALA L CB  1 
ATOM   4312 N N   . THR C 3 20  ? 130.395 106.749 93.124  1.00 49.75  ? 20  THR L N   1 
ATOM   4313 C CA  . THR C 3 20  ? 130.873 107.546 94.245  1.00 49.75  ? 20  THR L CA  1 
ATOM   4314 C C   . THR C 3 20  ? 131.867 108.578 93.737  1.00 49.75  ? 20  THR L C   1 
ATOM   4315 O O   . THR C 3 20  ? 132.679 108.289 92.853  1.00 49.75  ? 20  THR L O   1 
ATOM   4316 C CB  . THR C 3 20  ? 131.486 106.668 95.341  1.00 49.75  ? 20  THR L CB  1 
ATOM   4317 O OG1 . THR C 3 20  ? 131.982 107.496 96.398  1.00 49.75  ? 20  THR L OG1 1 
ATOM   4318 C CG2 . THR C 3 20  ? 132.593 105.764 94.818  1.00 49.75  ? 20  THR L CG2 1 
ATOM   4319 N N   . LEU C 3 21  ? 131.776 109.791 94.268  1.00 46.47  ? 21  LEU L N   1 
ATOM   4320 C CA  . LEU C 3 21  ? 132.553 110.920 93.789  1.00 46.47  ? 21  LEU L CA  1 
ATOM   4321 C C   . LEU C 3 21  ? 133.146 111.626 94.990  1.00 46.47  ? 21  LEU L C   1 
ATOM   4322 O O   . LEU C 3 21  ? 132.415 112.231 95.774  1.00 46.47  ? 21  LEU L O   1 
ATOM   4323 C CB  . LEU C 3 21  ? 131.689 111.891 92.990  1.00 46.47  ? 21  LEU L CB  1 
ATOM   4324 C CG  . LEU C 3 21  ? 131.211 111.559 91.576  1.00 46.47  ? 21  LEU L CG  1 
ATOM   4325 C CD1 . LEU C 3 21  ? 129.971 110.694 91.568  1.00 46.47  ? 21  LEU L CD1 1 
ATOM   4326 C CD2 . LEU C 3 21  ? 130.976 112.833 90.809  1.00 46.47  ? 21  LEU L CD2 1 
ATOM   4327 N N   . SER C 3 22  ? 134.456 111.565 95.128  1.00 45.27  ? 22  SER L N   1 
ATOM   4328 C CA  . SER C 3 22  ? 135.122 112.133 96.281  1.00 45.27  ? 22  SER L CA  1 
ATOM   4329 C C   . SER C 3 22  ? 135.399 113.605 96.040  1.00 45.27  ? 22  SER L C   1 
ATOM   4330 O O   . SER C 3 22  ? 135.338 114.084 94.907  1.00 45.27  ? 22  SER L O   1 
ATOM   4331 C CB  . SER C 3 22  ? 136.428 111.404 96.580  1.00 45.27  ? 22  SER L CB  1 
ATOM   4332 O OG  . SER C 3 22  ? 137.382 111.647 95.565  1.00 45.27  ? 22  SER L OG  1 
ATOM   4333 N N   . CYS C 3 23  ? 135.711 114.312 97.123  1.00 45.80  ? 23  CYS L N   1 
ATOM   4334 C CA  . CYS C 3 23  ? 135.992 115.736 97.075  1.00 45.80  ? 23  CYS L CA  1 
ATOM   4335 C C   . CYS C 3 23  ? 136.744 116.112 98.336  1.00 45.80  ? 23  CYS L C   1 
ATOM   4336 O O   . CYS C 3 23  ? 136.185 116.047 99.430  1.00 45.80  ? 23  CYS L O   1 
ATOM   4337 C CB  . CYS C 3 23  ? 134.698 116.531 96.972  1.00 45.80  ? 23  CYS L CB  1 
ATOM   4338 S SG  . CYS C 3 23  ? 134.866 118.280 96.620  1.00 45.80  ? 23  CYS L SG  1 
ATOM   4339 N N   . ARG C 3 24  ? 137.997 116.507 98.188  1.00 46.96  ? 24  ARG L N   1 
ATOM   4340 C CA  . ARG C 3 24  ? 138.816 116.909 99.313  1.00 46.96  ? 24  ARG L CA  1 
ATOM   4341 C C   . ARG C 3 24  ? 138.867 118.423 99.389  1.00 46.96  ? 24  ARG L C   1 
ATOM   4342 O O   . ARG C 3 24  ? 138.472 119.130 98.463  1.00 46.96  ? 24  ARG L O   1 
ATOM   4343 C CB  . ARG C 3 24  ? 140.231 116.339 99.207  1.00 46.96  ? 24  ARG L CB  1 
ATOM   4344 C CG  . ARG C 3 24  ? 140.310 114.853 99.443  1.00 46.96  ? 24  ARG L CG  1 
ATOM   4345 C CD  . ARG C 3 24  ? 141.743 114.374 99.426  1.00 46.96  ? 24  ARG L CD  1 
ATOM   4346 N NE  . ARG C 3 24  ? 142.322 114.434 98.090  1.00 46.96  ? 24  ARG L NE  1 
ATOM   4347 C CZ  . ARG C 3 24  ? 143.303 115.259 97.737  1.00 46.96  ? 24  ARG L CZ  1 
ATOM   4348 N NH1 . ARG C 3 24  ? 143.812 116.102 98.625  1.00 46.96  ? 24  ARG L NH1 1 
ATOM   4349 N NH2 . ARG C 3 24  ? 143.770 115.245 96.496  1.00 46.96  ? 24  ARG L NH2 1 
ATOM   4350 N N   . ALA C 3 25  ? 139.370 118.915 100.514 1.00 46.15  ? 25  ALA L N   1 
ATOM   4351 C CA  . ALA C 3 25  ? 139.411 120.337 100.785 1.00 46.15  ? 25  ALA L CA  1 
ATOM   4352 C C   . ALA C 3 25  ? 140.812 120.707 101.220 1.00 46.15  ? 25  ALA L C   1 
ATOM   4353 O O   . ALA C 3 25  ? 141.613 119.847 101.580 1.00 46.15  ? 25  ALA L O   1 
ATOM   4354 C CB  . ALA C 3 25  ? 138.404 120.726 101.863 1.00 46.15  ? 25  ALA L CB  1 
ATOM   4355 N N   . SER C 3 26  ? 141.110 122.001 101.176 1.00 48.99  ? 26  SER L N   1 
ATOM   4356 C CA  . SER C 3 26  ? 142.420 122.454 101.626 1.00 48.99  ? 26  SER L CA  1 
ATOM   4357 C C   . SER C 3 26  ? 142.475 122.553 103.143 1.00 48.99  ? 26  SER L C   1 
ATOM   4358 O O   . SER C 3 26  ? 143.539 122.378 103.743 1.00 48.99  ? 26  SER L O   1 
ATOM   4359 C CB  . SER C 3 26  ? 142.762 123.796 100.988 1.00 48.99  ? 26  SER L CB  1 
ATOM   4360 O OG  . SER C 3 26  ? 144.023 124.256 101.431 1.00 48.99  ? 26  SER L OG  1 
ATOM   4361 N N   . GLN C 3 27  ? 141.344 122.846 103.776 1.00 49.18  ? 27  GLN L N   1 
ATOM   4362 C CA  . GLN C 3 27  ? 141.267 122.920 105.225 1.00 49.18  ? 27  GLN L CA  1 
ATOM   4363 C C   . GLN C 3 27  ? 139.875 122.486 105.654 1.00 49.18  ? 27  GLN L C   1 
ATOM   4364 O O   . GLN C 3 27  ? 139.068 122.034 104.844 1.00 49.18  ? 27  GLN L O   1 
ATOM   4365 C CB  . GLN C 3 27  ? 141.594 124.324 105.728 1.00 49.18  ? 27  GLN L CB  1 
ATOM   4366 C CG  . GLN C 3 27  ? 140.612 125.388 105.278 1.00 49.18  ? 27  GLN L CG  1 
ATOM   4367 C CD  . GLN C 3 27  ? 141.011 126.772 105.730 1.00 49.18  ? 27  GLN L CD  1 
ATOM   4368 O OE1 . GLN C 3 27  ? 142.023 126.949 106.402 1.00 49.18  ? 27  GLN L OE1 1 
ATOM   4369 N NE2 . GLN C 3 27  ? 140.211 127.762 105.374 1.00 49.18  ? 27  GLN L NE2 1 
ATOM   4370 N N   . ASN C 3 28  ? 139.602 122.622 106.945 1.00 47.22  ? 28  ASN L N   1 
ATOM   4371 C CA  . ASN C 3 28  ? 138.342 122.141 107.487 1.00 47.22  ? 28  ASN L CA  1 
ATOM   4372 C C   . ASN C 3 28  ? 137.195 123.060 107.107 1.00 47.22  ? 28  ASN L C   1 
ATOM   4373 O O   . ASN C 3 28  ? 137.107 124.197 107.570 1.00 47.22  ? 28  ASN L O   1 
ATOM   4374 C CB  . ASN C 3 28  ? 138.418 122.042 109.007 1.00 47.22  ? 28  ASN L CB  1 
ATOM   4375 C CG  . ASN C 3 28  ? 139.306 120.931 109.472 1.00 47.22  ? 28  ASN L CG  1 
ATOM   4376 O OD1 . ASN C 3 28  ? 139.271 119.830 108.935 1.00 47.22  ? 28  ASN L OD1 1 
ATOM   4377 N ND2 . ASN C 3 28  ? 140.117 121.209 110.480 1.00 47.22  ? 28  ASN L ND2 1 
ATOM   4378 N N   . ILE C 3 29  ? 136.309 122.563 106.265 1.00 44.41  ? 29  ILE L N   1 
ATOM   4379 C CA  . ILE C 3 29  ? 134.997 123.161 106.116 1.00 44.41  ? 29  ILE L CA  1 
ATOM   4380 C C   . ILE C 3 29  ? 134.022 122.179 106.754 1.00 44.41  ? 29  ILE L C   1 
ATOM   4381 O O   . ILE C 3 29  ? 133.996 120.988 106.438 1.00 44.41  ? 29  ILE L O   1 
ATOM   4382 C CB  . ILE C 3 29  ? 134.684 123.520 104.633 1.00 44.41  ? 29  ILE L CB  1 
ATOM   4383 C CG1 . ILE C 3 29  ? 134.535 122.328 103.697 1.00 44.41  ? 29  ILE L CG1 1 
ATOM   4384 C CG2 . ILE C 3 29  ? 135.867 124.237 104.034 1.00 44.41  ? 29  ILE L CG2 1 
ATOM   4385 C CD1 . ILE C 3 29  ? 133.984 122.691 102.349 1.00 44.41  ? 29  ILE L CD1 1 
ATOM   4386 N N   . ILE C 3 30  ? 133.308 122.640 107.760 1.00 43.25  ? 30  ILE L N   1 
ATOM   4387 C CA  . ILE C 3 30  ? 132.567 121.721 108.605 1.00 43.25  ? 30  ILE L CA  1 
ATOM   4388 C C   . ILE C 3 30  ? 131.158 121.595 108.050 1.00 43.25  ? 30  ILE L C   1 
ATOM   4389 O O   . ILE C 3 30  ? 130.231 122.285 108.492 1.00 43.25  ? 30  ILE L O   1 
ATOM   4390 C CB  . ILE C 3 30  ? 132.613 122.131 110.086 1.00 43.25  ? 30  ILE L CB  1 
ATOM   4391 C CG1 . ILE C 3 30  ? 132.411 123.627 110.306 1.00 43.25  ? 30  ILE L CG1 1 
ATOM   4392 C CG2 . ILE C 3 30  ? 133.953 121.756 110.683 1.00 43.25  ? 30  ILE L CG2 1 
ATOM   4393 C CD1 . ILE C 3 30  ? 132.301 123.972 111.764 1.00 43.25  ? 30  ILE L CD1 1 
ATOM   4394 N N   . THR C 3 31  ? 130.998 120.669 107.107 1.00 44.06  ? 31  THR L N   1 
ATOM   4395 C CA  . THR C 3 31  ? 129.800 120.515 106.273 1.00 44.06  ? 31  THR L CA  1 
ATOM   4396 C C   . THR C 3 31  ? 129.380 121.830 105.627 1.00 44.06  ? 31  THR L C   1 
ATOM   4397 O O   . THR C 3 31  ? 128.203 122.177 105.592 1.00 44.06  ? 31  THR L O   1 
ATOM   4398 C CB  . THR C 3 31  ? 128.631 119.896 107.043 1.00 44.06  ? 31  THR L CB  1 
ATOM   4399 O OG1 . THR C 3 31  ? 128.224 120.770 108.100 1.00 44.06  ? 31  THR L OG1 1 
ATOM   4400 C CG2 . THR C 3 31  ? 129.028 118.558 107.624 1.00 44.06  ? 31  THR L CG2 1 
ATOM   4401 N N   . ASN C 3 32  ? 130.355 122.564 105.105 1.00 42.21  ? 32  ASN L N   1 
ATOM   4402 C CA  . ASN C 3 32  ? 130.115 123.754 104.301 1.00 42.21  ? 32  ASN L CA  1 
ATOM   4403 C C   . ASN C 3 32  ? 130.314 123.466 102.820 1.00 42.21  ? 32  ASN L C   1 
ATOM   4404 O O   . ASN C 3 32  ? 130.833 124.305 102.089 1.00 42.21  ? 32  ASN L O   1 
ATOM   4405 C CB  . ASN C 3 32  ? 131.023 124.905 104.730 1.00 42.21  ? 32  ASN L CB  1 
ATOM   4406 C CG  . ASN C 3 32  ? 130.629 125.509 106.056 1.00 42.21  ? 32  ASN L CG  1 
ATOM   4407 O OD1 . ASN C 3 32  ? 131.366 125.435 107.028 1.00 42.21  ? 32  ASN L OD1 1 
ATOM   4408 N ND2 . ASN C 3 32  ? 129.471 126.139 106.091 1.00 42.21  ? 32  ASN L ND2 1 
ATOM   4409 N N   . LEU C 3 33  ? 129.924 122.286 102.357 1.00 40.94  ? 33  LEU L N   1 
ATOM   4410 C CA  . LEU C 3 33  ? 130.156 121.895 100.978 1.00 40.94  ? 33  LEU L CA  1 
ATOM   4411 C C   . LEU C 3 33  ? 128.831 121.553 100.330 1.00 40.94  ? 33  LEU L C   1 
ATOM   4412 O O   . LEU C 3 33  ? 127.984 120.911 100.947 1.00 40.94  ? 33  LEU L O   1 
ATOM   4413 C CB  . LEU C 3 33  ? 131.105 120.707 100.881 1.00 40.94  ? 33  LEU L CB  1 
ATOM   4414 C CG  . LEU C 3 33  ? 131.349 120.183 99.471  1.00 40.94  ? 33  LEU L CG  1 
ATOM   4415 C CD1 . LEU C 3 33  ? 132.001 121.252 98.684  1.00 40.94  ? 33  LEU L CD1 1 
ATOM   4416 C CD2 . LEU C 3 33  ? 132.212 118.972 99.458  1.00 40.94  ? 33  LEU L CD2 1 
ATOM   4417 N N   . HIS C 3 34  ? 128.669 121.964 99.082  1.00 40.09  ? 34  HIS L N   1 
ATOM   4418 C CA  . HIS C 3 34  ? 127.441 121.789 98.338  1.00 40.09  ? 34  HIS L CA  1 
ATOM   4419 C C   . HIS C 3 34  ? 127.776 121.096 97.024  1.00 40.09  ? 34  HIS L C   1 
ATOM   4420 O O   . HIS C 3 34  ? 128.911 121.142 96.557  1.00 40.09  ? 34  HIS L O   1 
ATOM   4421 C CB  . HIS C 3 34  ? 126.793 123.146 98.095  1.00 40.09  ? 34  HIS L CB  1 
ATOM   4422 C CG  . HIS C 3 34  ? 126.774 124.022 99.310  1.00 40.09  ? 34  HIS L CG  1 
ATOM   4423 N ND1 . HIS C 3 34  ? 125.929 123.811 100.375 1.00 40.09  ? 34  HIS L ND1 1 
ATOM   4424 C CD2 . HIS C 3 34  ? 127.519 125.102 99.635  1.00 40.09  ? 34  HIS L CD2 1 
ATOM   4425 C CE1 . HIS C 3 34  ? 126.148 124.727 101.298 1.00 40.09  ? 34  HIS L CE1 1 
ATOM   4426 N NE2 . HIS C 3 34  ? 127.106 125.524 100.872 1.00 40.09  ? 34  HIS L NE2 1 
ATOM   4427 N N   . TRP C 3 35  ? 126.791 120.438 96.428  1.00 41.96  ? 35  TRP L N   1 
ATOM   4428 C CA  . TRP C 3 35  ? 127.018 119.630 95.237  1.00 41.96  ? 35  TRP L CA  1 
ATOM   4429 C C   . TRP C 3 35  ? 126.096 120.077 94.116  1.00 41.96  ? 35  TRP L C   1 
ATOM   4430 O O   . TRP C 3 35  ? 124.911 120.317 94.348  1.00 41.96  ? 35  TRP L O   1 
ATOM   4431 C CB  . TRP C 3 35  ? 126.804 118.144 95.538  1.00 41.96  ? 35  TRP L CB  1 
ATOM   4432 C CG  . TRP C 3 35  ? 127.892 117.518 96.351  1.00 41.96  ? 35  TRP L CG  1 
ATOM   4433 C CD1 . TRP C 3 35  ? 127.934 117.402 97.699  1.00 41.96  ? 35  TRP L CD1 1 
ATOM   4434 C CD2 . TRP C 3 35  ? 129.084 116.900 95.858  1.00 41.96  ? 35  TRP L CD2 1 
ATOM   4435 N NE1 . TRP C 3 35  ? 129.085 116.770 98.084  1.00 41.96  ? 35  TRP L NE1 1 
ATOM   4436 C CE2 . TRP C 3 35  ? 129.808 116.451 96.969  1.00 41.96  ? 35  TRP L CE2 1 
ATOM   4437 C CE3 . TRP C 3 35  ? 129.613 116.693 94.583  1.00 41.96  ? 35  TRP L CE3 1 
ATOM   4438 C CZ2 . TRP C 3 35  ? 131.027 115.803 96.848  1.00 41.96  ? 35  TRP L CZ2 1 
ATOM   4439 C CZ3 . TRP C 3 35  ? 130.823 116.050 94.466  1.00 41.96  ? 35  TRP L CZ3 1 
ATOM   4440 C CH2 . TRP C 3 35  ? 131.510 115.604 95.591  1.00 41.96  ? 35  TRP L CH2 1 
ATOM   4441 N N   . TYR C 3 36  ? 126.631 120.163 92.900  1.00 41.79  ? 36  TYR L N   1 
ATOM   4442 C CA  . TYR C 3 36  ? 125.900 120.696 91.760  1.00 41.79  ? 36  TYR L CA  1 
ATOM   4443 C C   . TYR C 3 36  ? 125.941 119.725 90.599  1.00 41.79  ? 36  TYR L C   1 
ATOM   4444 O O   . TYR C 3 36  ? 126.917 119.007 90.408  1.00 41.79  ? 36  TYR L O   1 
ATOM   4445 C CB  . TYR C 3 36  ? 126.471 122.027 91.286  1.00 41.79  ? 36  TYR L CB  1 
ATOM   4446 C CG  . TYR C 3 36  ? 126.296 123.139 92.278  1.00 41.79  ? 36  TYR L CG  1 
ATOM   4447 C CD1 . TYR C 3 36  ? 125.148 123.910 92.294  1.00 41.79  ? 36  TYR L CD1 1 
ATOM   4448 C CD2 . TYR C 3 36  ? 127.268 123.387 93.226  1.00 41.79  ? 36  TYR L CD2 1 
ATOM   4449 C CE1 . TYR C 3 36  ? 124.991 124.900 93.211  1.00 41.79  ? 36  TYR L CE1 1 
ATOM   4450 C CE2 . TYR C 3 36  ? 127.109 124.362 94.139  1.00 41.79  ? 36  TYR L CE2 1 
ATOM   4451 C CZ  . TYR C 3 36  ? 125.982 125.119 94.132  1.00 41.79  ? 36  TYR L CZ  1 
ATOM   4452 O OH  . TYR C 3 36  ? 125.858 126.107 95.069  1.00 41.79  ? 36  TYR L OH  1 
ATOM   4453 N N   . GLN C 3 37  ? 124.873 119.731 89.815  1.00 45.01  ? 37  GLN L N   1 
ATOM   4454 C CA  . GLN C 3 37  ? 124.770 118.967 88.583  1.00 45.01  ? 37  GLN L CA  1 
ATOM   4455 C C   . GLN C 3 37  ? 124.670 119.927 87.415  1.00 45.01  ? 37  GLN L C   1 
ATOM   4456 O O   . GLN C 3 37  ? 123.807 120.807 87.413  1.00 45.01  ? 37  GLN L O   1 
ATOM   4457 C CB  . GLN C 3 37  ? 123.541 118.067 88.596  1.00 45.01  ? 37  GLN L CB  1 
ATOM   4458 C CG  . GLN C 3 37  ? 123.291 117.361 87.293  1.00 45.01  ? 37  GLN L CG  1 
ATOM   4459 C CD  . GLN C 3 37  ? 122.118 116.438 87.364  1.00 45.01  ? 37  GLN L CD  1 
ATOM   4460 O OE1 . GLN C 3 37  ? 121.461 116.342 88.389  1.00 45.01  ? 37  GLN L OE1 1 
ATOM   4461 N NE2 . GLN C 3 37  ? 121.839 115.751 86.273  1.00 45.01  ? 37  GLN L NE2 1 
ATOM   4462 N N   . GLN C 3 38  ? 125.531 119.760 86.418  1.00 45.51  ? 38  GLN L N   1 
ATOM   4463 C CA  . GLN C 3 38  ? 125.441 120.564 85.210  1.00 45.51  ? 38  GLN L CA  1 
ATOM   4464 C C   . GLN C 3 38  ? 125.377 119.664 83.992  1.00 45.51  ? 38  GLN L C   1 
ATOM   4465 O O   . GLN C 3 38  ? 126.393 119.105 83.576  1.00 45.51  ? 38  GLN L O   1 
ATOM   4466 C CB  . GLN C 3 38  ? 126.613 121.523 85.075  1.00 45.51  ? 38  GLN L CB  1 
ATOM   4467 C CG  . GLN C 3 38  ? 126.401 122.459 83.932  1.00 45.51  ? 38  GLN L CG  1 
ATOM   4468 C CD  . GLN C 3 38  ? 127.509 123.426 83.788  1.00 45.51  ? 38  GLN L CD  1 
ATOM   4469 O OE1 . GLN C 3 38  ? 128.501 123.352 84.499  1.00 45.51  ? 38  GLN L OE1 1 
ATOM   4470 N NE2 . GLN C 3 38  ? 127.354 124.361 82.873  1.00 45.51  ? 38  GLN L NE2 1 
ATOM   4471 N N   . LYS C 3 39  ? 124.197 119.557 83.410  1.00 47.54  ? 39  LYS L N   1 
ATOM   4472 C CA  . LYS C 3 39  ? 124.026 118.967 82.102  1.00 47.54  ? 39  LYS L CA  1 
ATOM   4473 C C   . LYS C 3 39  ? 124.633 119.889 81.054  1.00 47.54  ? 39  LYS L C   1 
ATOM   4474 O O   . LYS C 3 39  ? 124.843 121.072 81.309  1.00 47.54  ? 39  LYS L O   1 
ATOM   4475 C CB  . LYS C 3 39  ? 122.543 118.722 81.861  1.00 47.54  ? 39  LYS L CB  1 
ATOM   4476 C CG  . LYS C 3 39  ? 121.978 117.638 82.725  1.00 47.54  ? 39  LYS L CG  1 
ATOM   4477 C CD  . LYS C 3 39  ? 120.541 117.351 82.367  1.00 47.54  ? 39  LYS L CD  1 
ATOM   4478 C CE  . LYS C 3 39  ? 119.975 116.283 83.270  1.00 47.54  ? 39  LYS L CE  1 
ATOM   4479 N NZ  . LYS C 3 39  ? 120.666 114.993 83.035  1.00 47.54  ? 39  LYS L NZ  1 
ATOM   4480 N N   . PRO C 3 40  ? 124.963 119.378 79.865  1.00 51.03  ? 40  PRO L N   1 
ATOM   4481 C CA  . PRO C 3 40  ? 125.502 120.264 78.825  1.00 51.03  ? 40  PRO L CA  1 
ATOM   4482 C C   . PRO C 3 40  ? 124.440 121.210 78.284  1.00 51.03  ? 40  PRO L C   1 
ATOM   4483 O O   . PRO C 3 40  ? 123.320 120.802 77.971  1.00 51.03  ? 40  PRO L O   1 
ATOM   4484 C CB  . PRO C 3 40  ? 125.993 119.291 77.748  1.00 51.03  ? 40  PRO L CB  1 
ATOM   4485 C CG  . PRO C 3 40  ? 125.217 118.062 77.967  1.00 51.03  ? 40  PRO L CG  1 
ATOM   4486 C CD  . PRO C 3 40  ? 125.036 117.967 79.443  1.00 51.03  ? 40  PRO L CD  1 
ATOM   4487 N N   . GLY C 3 41  ? 124.805 122.486 78.189  1.00 50.75  ? 41  GLY L N   1 
ATOM   4488 C CA  . GLY C 3 41  ? 123.898 123.499 77.698  1.00 50.75  ? 41  GLY L CA  1 
ATOM   4489 C C   . GLY C 3 41  ? 123.019 124.131 78.747  1.00 50.75  ? 41  GLY L C   1 
ATOM   4490 O O   . GLY C 3 41  ? 122.124 124.906 78.398  1.00 50.75  ? 41  GLY L O   1 
ATOM   4491 N N   . GLN C 3 42  ? 123.245 123.836 80.025  1.00 47.88  ? 42  GLN L N   1 
ATOM   4492 C CA  . GLN C 3 42  ? 122.368 124.298 81.085  1.00 47.88  ? 42  GLN L CA  1 
ATOM   4493 C C   . GLN C 3 42  ? 123.190 124.888 82.217  1.00 47.88  ? 42  GLN L C   1 
ATOM   4494 O O   . GLN C 3 42  ? 124.417 124.796 82.245  1.00 47.88  ? 42  GLN L O   1 
ATOM   4495 C CB  . GLN C 3 42  ? 121.492 123.167 81.620  1.00 47.88  ? 42  GLN L CB  1 
ATOM   4496 C CG  . GLN C 3 42  ? 120.479 122.656 80.636  1.00 47.88  ? 42  GLN L CG  1 
ATOM   4497 C CD  . GLN C 3 42  ? 119.659 121.524 81.194  1.00 47.88  ? 42  GLN L CD  1 
ATOM   4498 O OE1 . GLN C 3 42  ? 119.888 121.073 82.315  1.00 47.88  ? 42  GLN L OE1 1 
ATOM   4499 N NE2 . GLN C 3 42  ? 118.692 121.055 80.417  1.00 47.88  ? 42  GLN L NE2 1 
ATOM   4500 N N   . ALA C 3 43  ? 122.488 125.498 83.155  1.00 45.29  ? 43  ALA L N   1 
ATOM   4501 C CA  . ALA C 3 43  ? 123.074 126.035 84.362  1.00 45.29  ? 43  ALA L CA  1 
ATOM   4502 C C   . ALA C 3 43  ? 123.310 124.910 85.357  1.00 45.29  ? 43  ALA L C   1 
ATOM   4503 O O   . ALA C 3 43  ? 122.691 123.851 85.255  1.00 45.29  ? 43  ALA L O   1 
ATOM   4504 C CB  . ALA C 3 43  ? 122.145 127.088 84.954  1.00 45.29  ? 43  ALA L CB  1 
ATOM   4505 N N   . PRO C 3 44  ? 124.228 125.092 86.305  1.00 43.20  ? 44  PRO L N   1 
ATOM   4506 C CA  . PRO C 3 44  ? 124.392 124.090 87.354  1.00 43.20  ? 44  PRO L CA  1 
ATOM   4507 C C   . PRO C 3 44  ? 123.179 124.054 88.259  1.00 43.20  ? 44  PRO L C   1 
ATOM   4508 O O   . PRO C 3 44  ? 122.552 125.076 88.520  1.00 43.20  ? 44  PRO L O   1 
ATOM   4509 C CB  . PRO C 3 44  ? 125.635 124.568 88.098  1.00 43.20  ? 44  PRO L CB  1 
ATOM   4510 C CG  . PRO C 3 44  ? 126.349 125.358 87.128  1.00 43.20  ? 44  PRO L CG  1 
ATOM   4511 C CD  . PRO C 3 44  ? 125.338 126.051 86.325  1.00 43.20  ? 44  PRO L CD  1 
ATOM   4512 N N   . ARG C 3 45  ? 122.834 122.861 88.725  1.00 44.44  ? 45  ARG L N   1 
ATOM   4513 C CA  . ARG C 3 45  ? 121.647 122.655 89.542  1.00 44.44  ? 45  ARG L CA  1 
ATOM   4514 C C   . ARG C 3 45  ? 122.064 122.025 90.861  1.00 44.44  ? 45  ARG L C   1 
ATOM   4515 O O   . ARG C 3 45  ? 122.649 120.938 90.869  1.00 44.44  ? 45  ARG L O   1 
ATOM   4516 C CB  . ARG C 3 45  ? 120.642 121.769 88.818  1.00 44.44  ? 45  ARG L CB  1 
ATOM   4517 C CG  . ARG C 3 45  ? 119.331 121.646 89.524  1.00 44.44  ? 45  ARG L CG  1 
ATOM   4518 C CD  . ARG C 3 45  ? 118.415 120.714 88.782  1.00 44.44  ? 45  ARG L CD  1 
ATOM   4519 N NE  . ARG C 3 45  ? 118.890 119.340 88.850  1.00 44.44  ? 45  ARG L NE  1 
ATOM   4520 C CZ  . ARG C 3 45  ? 118.353 118.331 88.176  1.00 44.44  ? 45  ARG L CZ  1 
ATOM   4521 N NH1 . ARG C 3 45  ? 117.317 118.541 87.379  1.00 44.44  ? 45  ARG L NH1 1 
ATOM   4522 N NH2 . ARG C 3 45  ? 118.848 117.109 88.302  1.00 44.44  ? 45  ARG L NH2 1 
ATOM   4523 N N   . LEU C 3 46  ? 121.761 122.709 91.966  1.00 44.57  ? 46  LEU L N   1 
ATOM   4524 C CA  . LEU C 3 46  ? 122.153 122.254 93.297  1.00 44.57  ? 46  LEU L CA  1 
ATOM   4525 C C   . LEU C 3 46  ? 121.447 120.962 93.664  1.00 44.57  ? 46  LEU L C   1 
ATOM   4526 O O   . LEU C 3 46  ? 120.226 120.850 93.532  1.00 44.57  ? 46  LEU L O   1 
ATOM   4527 C CB  . LEU C 3 46  ? 121.838 123.337 94.328  1.00 44.57  ? 46  LEU L CB  1 
ATOM   4528 C CG  . LEU C 3 46  ? 122.101 123.090 95.806  1.00 44.57  ? 46  LEU L CG  1 
ATOM   4529 C CD1 . LEU C 3 46  ? 123.539 122.800 96.048  1.00 44.57  ? 46  LEU L CD1 1 
ATOM   4530 C CD2 . LEU C 3 46  ? 121.721 124.320 96.557  1.00 44.57  ? 46  LEU L CD2 1 
ATOM   4531 N N   . LEU C 3 47  ? 122.228 119.980 94.113  1.00 46.15  ? 47  LEU L N   1 
ATOM   4532 C CA  . LEU C 3 47  ? 121.721 118.665 94.474  1.00 46.15  ? 47  LEU L CA  1 
ATOM   4533 C C   . LEU C 3 47  ? 121.666 118.446 95.975  1.00 46.15  ? 47  LEU L C   1 
ATOM   4534 O O   . LEU C 3 47  ? 120.648 117.986 96.495  1.00 46.15  ? 47  LEU L O   1 
ATOM   4535 C CB  . LEU C 3 47  ? 122.575 117.564 93.834  1.00 46.15  ? 47  LEU L CB  1 
ATOM   4536 C CG  . LEU C 3 47  ? 122.570 117.417 92.319  1.00 46.15  ? 47  LEU L CG  1 
ATOM   4537 C CD1 . LEU C 3 47  ? 123.528 116.328 91.920  1.00 46.15  ? 47  LEU L CD1 1 
ATOM   4538 C CD2 . LEU C 3 47  ? 121.188 117.118 91.819  1.00 46.15  ? 47  LEU L CD2 1 
ATOM   4539 N N   . ILE C 3 48  ? 122.756 118.724 96.682  1.00 43.68  ? 48  ILE L N   1 
ATOM   4540 C CA  . ILE C 3 48  ? 122.861 118.498 98.116  1.00 43.68  ? 48  ILE L CA  1 
ATOM   4541 C C   . ILE C 3 48  ? 123.456 119.743 98.747  1.00 43.68  ? 48  ILE L C   1 
ATOM   4542 O O   . ILE C 3 48  ? 124.480 120.246 98.281  1.00 43.68  ? 48  ILE L O   1 
ATOM   4543 C CB  . ILE C 3 48  ? 123.713 117.253 98.438  1.00 43.68  ? 48  ILE L CB  1 
ATOM   4544 C CG1 . ILE C 3 48  ? 122.932 115.970 98.181  1.00 43.68  ? 48  ILE L CG1 1 
ATOM   4545 C CG2 . ILE C 3 48  ? 124.197 117.248 99.857  1.00 43.68  ? 48  ILE L CG2 1 
ATOM   4546 C CD1 . ILE C 3 48  ? 123.127 115.380 96.831  1.00 43.68  ? 48  ILE L CD1 1 
ATOM   4547 N N   . LYS C 3 49  ? 122.805 120.252 99.787  1.00 42.00  ? 49  LYS L N   1 
ATOM   4548 C CA  . LYS C 3 49  ? 123.318 121.364 100.571 1.00 42.00  ? 49  LYS L CA  1 
ATOM   4549 C C   . LYS C 3 49  ? 123.862 120.879 101.904 1.00 42.00  ? 49  LYS L C   1 
ATOM   4550 O O   . LYS C 3 49  ? 123.318 119.955 102.506 1.00 42.00  ? 49  LYS L O   1 
ATOM   4551 C CB  . LYS C 3 49  ? 122.233 122.416 100.778 1.00 42.00  ? 49  LYS L CB  1 
ATOM   4552 C CG  . LYS C 3 49  ? 120.939 121.875 101.347 1.00 42.00  ? 49  LYS L CG  1 
ATOM   4553 C CD  . LYS C 3 49  ? 119.885 122.954 101.433 1.00 42.00  ? 49  LYS L CD  1 
ATOM   4554 C CE  . LYS C 3 49  ? 118.554 122.367 101.817 1.00 42.00  ? 49  LYS L CE  1 
ATOM   4555 N NZ  . LYS C 3 49  ? 117.497 123.395 101.818 1.00 42.00  ? 49  LYS L NZ  1 
ATOM   4556 N N   . TYR C 3 50  ? 124.964 121.492 102.324 1.00 42.24  ? 50  TYR L N   1 
ATOM   4557 C CA  . TYR C 3 50  ? 125.598 121.284 103.628 1.00 42.24  ? 50  TYR L CA  1 
ATOM   4558 C C   . TYR C 3 50  ? 125.998 119.832 103.836 1.00 42.24  ? 50  TYR L C   1 
ATOM   4559 O O   . TYR C 3 50  ? 125.873 119.276 104.929 1.00 42.24  ? 50  TYR L O   1 
ATOM   4560 C CB  . TYR C 3 50  ? 124.719 121.822 104.755 1.00 42.24  ? 50  TYR L CB  1 
ATOM   4561 C CG  . TYR C 3 50  ? 124.645 123.315 104.623 1.00 42.24  ? 50  TYR L CG  1 
ATOM   4562 C CD1 . TYR C 3 50  ? 125.715 124.095 104.989 1.00 42.24  ? 50  TYR L CD1 1 
ATOM   4563 C CD2 . TYR C 3 50  ? 123.549 123.933 104.056 1.00 42.24  ? 50  TYR L CD2 1 
ATOM   4564 C CE1 . TYR C 3 50  ? 125.688 125.434 104.831 1.00 42.24  ? 50  TYR L CE1 1 
ATOM   4565 C CE2 . TYR C 3 50  ? 123.514 125.278 103.898 1.00 42.24  ? 50  TYR L CE2 1 
ATOM   4566 C CZ  . TYR C 3 50  ? 124.590 126.020 104.287 1.00 42.24  ? 50  TYR L CZ  1 
ATOM   4567 O OH  . TYR C 3 50  ? 124.585 127.374 104.145 1.00 42.24  ? 50  TYR L OH  1 
ATOM   4568 N N   . ALA C 3 51  ? 126.413 119.214 102.728 1.00 42.10  ? 51  ALA L N   1 
ATOM   4569 C CA  . ALA C 3 51  ? 127.045 117.911 102.570 1.00 42.10  ? 51  ALA L CA  1 
ATOM   4570 C C   . ALA C 3 51  ? 126.120 116.732 102.807 1.00 42.10  ? 51  ALA L C   1 
ATOM   4571 O O   . ALA C 3 51  ? 126.495 115.606 102.490 1.00 42.10  ? 51  ALA L O   1 
ATOM   4572 C CB  . ALA C 3 51  ? 128.268 117.786 103.471 1.00 42.10  ? 51  ALA L CB  1 
ATOM   4573 N N   . SER C 3 52  ? 124.921 116.944 103.351 1.00 44.00  ? 52  SER L N   1 
ATOM   4574 C CA  . SER C 3 52  ? 124.035 115.801 103.525 1.00 44.00  ? 52  SER L CA  1 
ATOM   4575 C C   . SER C 3 52  ? 122.548 116.106 103.395 1.00 44.00  ? 52  SER L C   1 
ATOM   4576 O O   . SER C 3 52  ? 121.743 115.176 103.502 1.00 44.00  ? 52  SER L O   1 
ATOM   4577 C CB  . SER C 3 52  ? 124.273 115.174 104.882 1.00 44.00  ? 52  SER L CB  1 
ATOM   4578 O OG  . SER C 3 52  ? 123.934 116.083 105.908 1.00 44.00  ? 52  SER L OG  1 
ATOM   4579 N N   . GLN C 3 53  ? 122.144 117.342 103.157 1.00 45.27  ? 53  GLN L N   1 
ATOM   4580 C CA  . GLN C 3 53  ? 120.731 117.682 103.149 1.00 45.27  ? 53  GLN L CA  1 
ATOM   4581 C C   . GLN C 3 53  ? 120.235 117.650 101.719 1.00 45.27  ? 53  GLN L C   1 
ATOM   4582 O O   . GLN C 3 53  ? 120.921 118.108 100.808 1.00 45.27  ? 53  GLN L O   1 
ATOM   4583 C CB  . GLN C 3 53  ? 120.463 119.058 103.753 1.00 45.27  ? 53  GLN L CB  1 
ATOM   4584 C CG  . GLN C 3 53  ? 120.799 119.191 105.222 1.00 45.27  ? 53  GLN L CG  1 
ATOM   4585 C CD  . GLN C 3 53  ? 119.946 118.306 106.092 1.00 45.27  ? 53  GLN L CD  1 
ATOM   4586 O OE1 . GLN C 3 53  ? 120.432 117.349 106.689 1.00 45.27  ? 53  GLN L OE1 1 
ATOM   4587 N NE2 . GLN C 3 53  ? 118.659 118.612 106.160 1.00 45.27  ? 53  GLN L NE2 1 
ATOM   4588 N N   . SER C 3 54  ? 119.049 117.110 101.523 1.00 47.39  ? 54  SER L N   1 
ATOM   4589 C CA  . SER C 3 54  ? 118.507 116.914 100.194 1.00 47.39  ? 54  SER L CA  1 
ATOM   4590 C C   . SER C 3 54  ? 117.696 118.135 99.805  1.00 47.39  ? 54  SER L C   1 
ATOM   4591 O O   . SER C 3 54  ? 116.832 118.577 100.568 1.00 47.39  ? 54  SER L O   1 
ATOM   4592 C CB  . SER C 3 54  ? 117.636 115.664 100.142 1.00 47.39  ? 54  SER L CB  1 
ATOM   4593 O OG  . SER C 3 54  ? 116.461 115.846 100.910 1.00 47.39  ? 54  SER L OG  1 
ATOM   4594 N N   . ILE C 3 55  ? 117.988 118.684 98.626  1.00 47.87  ? 55  ILE L N   1 
ATOM   4595 C CA  . ILE C 3 55  ? 117.126 119.684 98.020  1.00 47.87  ? 55  ILE L CA  1 
ATOM   4596 C C   . ILE C 3 55  ? 115.802 119.028 97.666  1.00 47.87  ? 55  ILE L C   1 
ATOM   4597 O O   . ILE C 3 55  ? 115.768 117.902 97.155  1.00 47.87  ? 55  ILE L O   1 
ATOM   4598 C CB  . ILE C 3 55  ? 117.808 120.271 96.777  1.00 47.87  ? 55  ILE L CB  1 
ATOM   4599 C CG1 . ILE C 3 55  ? 119.163 120.858 97.132  1.00 47.87  ? 55  ILE L CG1 1 
ATOM   4600 C CG2 . ILE C 3 55  ? 116.947 121.327 96.115  1.00 47.87  ? 55  ILE L CG2 1 
ATOM   4601 C CD1 . ILE C 3 55  ? 119.082 122.032 98.003  1.00 47.87  ? 55  ILE L CD1 1 
ATOM   4602 N N   . SER C 3 56  ? 114.702 119.707 97.969  1.00 49.89  ? 56  SER L N   1 
ATOM   4603 C CA  . SER C 3 56  ? 113.390 119.176 97.643  1.00 49.89  ? 56  SER L CA  1 
ATOM   4604 C C   . SER C 3 56  ? 113.167 119.215 96.143  1.00 49.89  ? 56  SER L C   1 
ATOM   4605 O O   . SER C 3 56  ? 113.645 120.117 95.454  1.00 49.89  ? 56  SER L O   1 
ATOM   4606 C CB  . SER C 3 56  ? 112.303 119.974 98.354  1.00 49.89  ? 56  SER L CB  1 
ATOM   4607 O OG  . SER C 3 56  ? 112.252 121.303 97.869  1.00 49.89  ? 56  SER L OG  1 
ATOM   4608 N N   . GLY C 3 57  ? 112.446 118.223 95.636  1.00 52.69  ? 57  GLY L N   1 
ATOM   4609 C CA  . GLY C 3 57  ? 112.216 118.093 94.215  1.00 52.69  ? 57  GLY L CA  1 
ATOM   4610 C C   . GLY C 3 57  ? 113.230 117.244 93.483  1.00 52.69  ? 57  GLY L C   1 
ATOM   4611 O O   . GLY C 3 57  ? 113.140 117.120 92.256  1.00 52.69  ? 57  GLY L O   1 
ATOM   4612 N N   . ILE C 3 58  ? 114.184 116.661 94.191  1.00 53.07  ? 58  ILE L N   1 
ATOM   4613 C CA  . ILE C 3 58  ? 115.255 115.867 93.596  1.00 53.07  ? 58  ILE L CA  1 
ATOM   4614 C C   . ILE C 3 58  ? 115.079 114.416 94.028  1.00 53.07  ? 58  ILE L C   1 
ATOM   4615 O O   . ILE C 3 58  ? 114.834 114.168 95.216  1.00 53.07  ? 58  ILE L O   1 
ATOM   4616 C CB  . ILE C 3 58  ? 116.634 116.411 94.007  1.00 53.07  ? 58  ILE L CB  1 
ATOM   4617 C CG1 . ILE C 3 58  ? 116.870 117.724 93.281  1.00 53.07  ? 58  ILE L CG1 1 
ATOM   4618 C CG2 . ILE C 3 58  ? 117.760 115.424 93.748  1.00 53.07  ? 58  ILE L CG2 1 
ATOM   4619 C CD1 . ILE C 3 58  ? 118.120 118.374 93.647  1.00 53.07  ? 58  ILE L CD1 1 
ATOM   4620 N N   . PRO C 3 59  ? 115.151 113.451 93.106  1.00 54.55  ? 59  PRO L N   1 
ATOM   4621 C CA  . PRO C 3 59  ? 114.985 112.045 93.488  1.00 54.55  ? 59  PRO L CA  1 
ATOM   4622 C C   . PRO C 3 59  ? 116.109 111.567 94.393  1.00 54.55  ? 59  PRO L C   1 
ATOM   4623 O O   . PRO C 3 59  ? 117.288 111.818 94.145  1.00 54.55  ? 59  PRO L O   1 
ATOM   4624 C CB  . PRO C 3 59  ? 114.990 111.312 92.144  1.00 54.55  ? 59  PRO L CB  1 
ATOM   4625 C CG  . PRO C 3 59  ? 115.706 112.224 91.217  1.00 54.55  ? 59  PRO L CG  1 
ATOM   4626 C CD  . PRO C 3 59  ? 115.349 113.605 91.656  1.00 54.55  ? 59  PRO L CD  1 
ATOM   4627 N N   . ALA C 3 60  ? 115.723 110.856 95.449  1.00 55.90  ? 60  ALA L N   1 
ATOM   4628 C CA  . ALA C 3 60  ? 116.622 110.582 96.560  1.00 55.90  ? 60  ALA L CA  1 
ATOM   4629 C C   . ALA C 3 60  ? 117.536 109.394 96.307  1.00 55.90  ? 60  ALA L C   1 
ATOM   4630 O O   . ALA C 3 60  ? 117.630 108.488 97.141  1.00 55.90  ? 60  ALA L O   1 
ATOM   4631 C CB  . ALA C 3 60  ? 115.816 110.352 97.840  1.00 55.90  ? 60  ALA L CB  1 
ATOM   4632 N N   . ARG C 3 61  ? 118.214 109.384 95.165  1.00 55.13  ? 61  ARG L N   1 
ATOM   4633 C CA  . ARG C 3 61  ? 119.381 108.545 94.990  1.00 55.13  ? 61  ARG L CA  1 
ATOM   4634 C C   . ARG C 3 61  ? 120.655 109.324 95.206  1.00 55.13  ? 61  ARG L C   1 
ATOM   4635 O O   . ARG C 3 61  ? 121.718 108.720 95.342  1.00 55.13  ? 61  ARG L O   1 
ATOM   4636 C CB  . ARG C 3 61  ? 119.403 107.929 93.588  1.00 55.13  ? 61  ARG L CB  1 
ATOM   4637 C CG  . ARG C 3 61  ? 119.641 108.934 92.502  1.00 55.13  ? 61  ARG L CG  1 
ATOM   4638 C CD  . ARG C 3 61  ? 119.682 108.283 91.153  1.00 55.13  ? 61  ARG L CD  1 
ATOM   4639 N NE  . ARG C 3 61  ? 118.375 107.820 90.707  1.00 55.13  ? 61  ARG L NE  1 
ATOM   4640 C CZ  . ARG C 3 61  ? 117.562 108.522 89.927  1.00 55.13  ? 61  ARG L CZ  1 
ATOM   4641 N NH1 . ARG C 3 61  ? 117.928 109.714 89.485  1.00 55.13  ? 61  ARG L NH1 1 
ATOM   4642 N NH2 . ARG C 3 61  ? 116.388 108.023 89.572  1.00 55.13  ? 61  ARG L NH2 1 
ATOM   4643 N N   . PHE C 3 62  ? 120.557 110.645 95.260  1.00 51.51  ? 62  PHE L N   1 
ATOM   4644 C CA  . PHE C 3 62  ? 121.693 111.531 95.445  1.00 51.51  ? 62  PHE L CA  1 
ATOM   4645 C C   . PHE C 3 62  ? 121.836 111.796 96.934  1.00 51.51  ? 62  PHE L C   1 
ATOM   4646 O O   . PHE C 3 62  ? 121.027 112.523 97.514  1.00 51.51  ? 62  PHE L O   1 
ATOM   4647 C CB  . PHE C 3 62  ? 121.461 112.845 94.701  1.00 51.51  ? 62  PHE L CB  1 
ATOM   4648 C CG  . PHE C 3 62  ? 121.380 112.710 93.213  1.00 51.51  ? 62  PHE L CG  1 
ATOM   4649 C CD1 . PHE C 3 62  ? 121.988 111.671 92.555  1.00 51.51  ? 62  PHE L CD1 1 
ATOM   4650 C CD2 . PHE C 3 62  ? 120.642 113.609 92.481  1.00 51.51  ? 62  PHE L CD2 1 
ATOM   4651 C CE1 . PHE C 3 62  ? 121.889 111.552 91.193  1.00 51.51  ? 62  PHE L CE1 1 
ATOM   4652 C CE2 . PHE C 3 62  ? 120.540 113.494 91.120  1.00 51.51  ? 62  PHE L CE2 1 
ATOM   4653 C CZ  . PHE C 3 62  ? 121.166 112.465 90.478  1.00 51.51  ? 62  PHE L CZ  1 
ATOM   4654 N N   . SER C 3 63  ? 122.846 111.212 97.556  1.00 47.94  ? 63  SER L N   1 
ATOM   4655 C CA  . SER C 3 63  ? 123.007 111.410 98.982  1.00 47.94  ? 63  SER L CA  1 
ATOM   4656 C C   . SER C 3 63  ? 124.478 111.561 99.290  1.00 47.94  ? 63  SER L C   1 
ATOM   4657 O O   . SER C 3 63  ? 125.286 110.723 98.899  1.00 47.94  ? 63  SER L O   1 
ATOM   4658 C CB  . SER C 3 63  ? 122.413 110.248 99.769  1.00 47.94  ? 63  SER L CB  1 
ATOM   4659 O OG  . SER C 3 63  ? 121.012 110.181 99.577  1.00 47.94  ? 63  SER L OG  1 
ATOM   4660 N N   . GLY C 3 64  ? 124.814 112.622 100.004 1.00 45.18  ? 64  GLY L N   1 
ATOM   4661 C CA  . GLY C 3 64  ? 126.200 112.902 100.290 1.00 45.18  ? 64  GLY L CA  1 
ATOM   4662 C C   . GLY C 3 64  ? 126.556 112.641 101.730 1.00 45.18  ? 64  GLY L C   1 
ATOM   4663 O O   . GLY C 3 64  ? 125.675 112.545 102.582 1.00 45.18  ? 64  GLY L O   1 
ATOM   4664 N N   . SER C 3 65  ? 127.844 112.524 102.009 1.00 44.16  ? 65  SER L N   1 
ATOM   4665 C CA  . SER C 3 65  ? 128.321 112.390 103.370 1.00 44.16  ? 65  SER L CA  1 
ATOM   4666 C C   . SER C 3 65  ? 129.760 112.846 103.405 1.00 44.16  ? 65  SER L C   1 
ATOM   4667 O O   . SER C 3 65  ? 130.449 112.810 102.390 1.00 44.16  ? 65  SER L O   1 
ATOM   4668 C CB  . SER C 3 65  ? 128.222 110.956 103.884 1.00 44.16  ? 65  SER L CB  1 
ATOM   4669 O OG  . SER C 3 65  ? 128.739 110.863 105.201 1.00 44.16  ? 65  SER L OG  1 
ATOM   4670 N N   . GLY C 3 66  ? 130.202 113.271 104.566 1.00 43.02  ? 66  GLY L N   1 
ATOM   4671 C CA  . GLY C 3 66  ? 131.551 113.771 104.710 1.00 43.02  ? 66  GLY L CA  1 
ATOM   4672 C C   . GLY C 3 66  ? 131.543 115.044 105.518 1.00 43.02  ? 66  GLY L C   1 
ATOM   4673 O O   . GLY C 3 66  ? 130.526 115.709 105.666 1.00 43.02  ? 66  GLY L O   1 
ATOM   4674 N N   . SER C 3 67  ? 132.715 115.380 106.034 1.00 43.49  ? 67  SER L N   1 
ATOM   4675 C CA  . SER C 3 67  ? 132.867 116.569 106.853 1.00 43.49  ? 67  SER L CA  1 
ATOM   4676 C C   . SER C 3 67  ? 134.331 116.946 106.856 1.00 43.49  ? 67  SER L C   1 
ATOM   4677 O O   . SER C 3 67  ? 135.190 116.154 106.469 1.00 43.49  ? 67  SER L O   1 
ATOM   4678 C CB  . SER C 3 67  ? 132.381 116.329 108.271 1.00 43.49  ? 67  SER L CB  1 
ATOM   4679 O OG  . SER C 3 67  ? 133.202 115.371 108.902 1.00 43.49  ? 67  SER L OG  1 
ATOM   4680 N N   . GLY C 3 68  ? 134.610 118.162 107.301 1.00 44.95  ? 68  GLY L N   1 
ATOM   4681 C CA  . GLY C 3 68  ? 135.989 118.565 107.484 1.00 44.95  ? 68  GLY L CA  1 
ATOM   4682 C C   . GLY C 3 68  ? 136.700 118.783 106.172 1.00 44.95  ? 68  GLY L C   1 
ATOM   4683 O O   . GLY C 3 68  ? 136.558 119.827 105.532 1.00 44.95  ? 68  GLY L O   1 
ATOM   4684 N N   . THR C 3 69  ? 137.496 117.791 105.781 1.00 45.17  ? 69  THR L N   1 
ATOM   4685 C CA  . THR C 3 69  ? 138.208 117.816 104.517 1.00 45.17  ? 69  THR L CA  1 
ATOM   4686 C C   . THR C 3 69  ? 137.610 116.923 103.434 1.00 45.17  ? 69  THR L C   1 
ATOM   4687 O O   . THR C 3 69  ? 137.338 117.422 102.341 1.00 45.17  ? 69  THR L O   1 
ATOM   4688 C CB  . THR C 3 69  ? 139.676 117.441 104.752 1.00 45.17  ? 69  THR L CB  1 
ATOM   4689 O OG1 . THR C 3 69  ? 140.279 118.447 105.572 1.00 45.17  ? 69  THR L OG1 1 
ATOM   4690 C CG2 . THR C 3 69  ? 140.435 117.341 103.452 1.00 45.17  ? 69  THR L CG2 1 
ATOM   4691 N N   . ASP C 3 70  ? 137.368 115.644 103.697 1.00 44.01  ? 70  ASP L N   1 
ATOM   4692 C CA  . ASP C 3 70  ? 137.031 114.690 102.643 1.00 44.01  ? 70  ASP L CA  1 
ATOM   4693 C C   . ASP C 3 70  ? 135.539 114.415 102.599 1.00 44.01  ? 70  ASP L C   1 
ATOM   4694 O O   . ASP C 3 70  ? 134.973 113.911 103.567 1.00 44.01  ? 70  ASP L O   1 
ATOM   4695 C CB  . ASP C 3 70  ? 137.773 113.370 102.837 1.00 44.01  ? 70  ASP L CB  1 
ATOM   4696 N N   . PHE C 3 71  ? 134.898 114.745 101.478 1.00 43.02  ? 71  PHE L N   1 
ATOM   4697 C CA  . PHE C 3 71  ? 133.455 114.591 101.381 1.00 43.02  ? 71  PHE L CA  1 
ATOM   4698 C C   . PHE C 3 71  ? 133.170 113.704 100.181 1.00 43.02  ? 71  PHE L C   1 
ATOM   4699 O O   . PHE C 3 71  ? 134.012 113.544 99.300  1.00 43.02  ? 71  PHE L O   1 
ATOM   4700 C CB  . PHE C 3 71  ? 132.618 115.885 101.186 1.00 43.02  ? 71  PHE L CB  1 
ATOM   4701 C CG  . PHE C 3 71  ? 132.867 117.051 102.181 1.00 43.02  ? 71  PHE L CG  1 
ATOM   4702 C CD1 . PHE C 3 71  ? 132.131 117.277 103.339 1.00 43.02  ? 71  PHE L CD1 1 
ATOM   4703 C CD2 . PHE C 3 71  ? 133.804 118.000 101.844 1.00 43.02  ? 71  PHE L CD2 1 
ATOM   4704 C CE1 . PHE C 3 71  ? 132.399 118.316 104.162 1.00 43.02  ? 71  PHE L CE1 1 
ATOM   4705 C CE2 . PHE C 3 71  ? 134.048 119.076 102.654 1.00 43.02  ? 71  PHE L CE2 1 
ATOM   4706 C CZ  . PHE C 3 71  ? 133.345 119.224 103.814 1.00 43.02  ? 71  PHE L CZ  1 
ATOM   4707 N N   . THR C 3 72  ? 131.980 113.107 100.151 1.00 43.63  ? 72  THR L N   1 
ATOM   4708 C CA  . THR C 3 72  ? 131.611 112.207 99.068  1.00 43.63  ? 72  THR L CA  1 
ATOM   4709 C C   . THR C 3 72  ? 130.206 112.501 98.574  1.00 43.63  ? 72  THR L C   1 
ATOM   4710 O O   . THR C 3 72  ? 129.411 113.144 99.254  1.00 43.63  ? 72  THR L O   1 
ATOM   4711 C CB  . THR C 3 72  ? 131.655 110.735 99.473  1.00 43.63  ? 72  THR L CB  1 
ATOM   4712 O OG1 . THR C 3 72  ? 130.815 110.529 100.612 1.00 43.63  ? 72  THR L OG1 1 
ATOM   4713 C CG2 . THR C 3 72  ? 133.076 110.263 99.770  1.00 43.63  ? 72  THR L CG2 1 
ATOM   4714 N N   . LEU C 3 73  ? 129.920 112.021 97.371  1.00 46.55  ? 73  LEU L N   1 
ATOM   4715 C CA  . LEU C 3 73  ? 128.599 112.061 96.765  1.00 46.55  ? 73  LEU L CA  1 
ATOM   4716 C C   . LEU C 3 73  ? 128.299 110.693 96.183  1.00 46.55  ? 73  LEU L C   1 
ATOM   4717 O O   . LEU C 3 73  ? 129.075 110.182 95.375  1.00 46.55  ? 73  LEU L O   1 
ATOM   4718 C CB  . LEU C 3 73  ? 128.523 113.111 95.667  1.00 46.55  ? 73  LEU L CB  1 
ATOM   4719 C CG  . LEU C 3 73  ? 127.198 113.108 94.919  1.00 46.55  ? 73  LEU L CG  1 
ATOM   4720 C CD1 . LEU C 3 73  ? 126.083 113.441 95.859  1.00 46.55  ? 73  LEU L CD1 1 
ATOM   4721 C CD2 . LEU C 3 73  ? 127.222 114.069 93.753  1.00 46.55  ? 73  LEU L CD2 1 
ATOM   4722 N N   . THR C 3 74  ? 127.180 110.106 96.577  1.00 49.97  ? 74  THR L N   1 
ATOM   4723 C CA  . THR C 3 74  ? 126.877 108.733 96.224  1.00 49.97  ? 74  THR L CA  1 
ATOM   4724 C C   . THR C 3 74  ? 125.543 108.664 95.509  1.00 49.97  ? 74  THR L C   1 
ATOM   4725 O O   . THR C 3 74  ? 124.532 109.154 96.011  1.00 49.97  ? 74  THR L O   1 
ATOM   4726 C CB  . THR C 3 74  ? 126.855 107.851 97.460  1.00 49.97  ? 74  THR L CB  1 
ATOM   4727 O OG1 . THR C 3 74  ? 128.119 107.944 98.124  1.00 49.97  ? 74  THR L OG1 1 
ATOM   4728 C CG2 . THR C 3 74  ? 126.623 106.405 97.078  1.00 49.97  ? 74  THR L CG2 1 
ATOM   4729 N N   . ILE C 3 75  ? 125.551 108.054 94.334  1.00 53.23  ? 75  ILE L N   1 
ATOM   4730 C CA  . ILE C 3 75  ? 124.353 107.813 93.546  1.00 53.23  ? 75  ILE L CA  1 
ATOM   4731 C C   . ILE C 3 75  ? 124.006 106.348 93.722  1.00 53.23  ? 75  ILE L C   1 
ATOM   4732 O O   . ILE C 3 75  ? 124.867 105.481 93.543  1.00 53.23  ? 75  ILE L O   1 
ATOM   4733 C CB  . ILE C 3 75  ? 124.565 108.158 92.066  1.00 53.23  ? 75  ILE L CB  1 
ATOM   4734 C CG1 . ILE C 3 75  ? 124.843 109.651 91.877  1.00 53.23  ? 75  ILE L CG1 1 
ATOM   4735 C CG2 . ILE C 3 75  ? 123.368 107.750 91.246  1.00 53.23  ? 75  ILE L CG2 1 
ATOM   4736 C CD1 . ILE C 3 75  ? 126.300 110.034 91.772  1.00 53.23  ? 75  ILE L CD1 1 
ATOM   4737 N N   . SER C 3 76  ? 122.759 106.067 94.100  1.00 55.57  ? 76  SER L N   1 
ATOM   4738 C CA  . SER C 3 76  ? 122.361 104.693 94.382  1.00 55.57  ? 76  SER L CA  1 
ATOM   4739 C C   . SER C 3 76  ? 122.277 103.875 93.105  1.00 55.57  ? 76  SER L C   1 
ATOM   4740 O O   . SER C 3 76  ? 123.043 102.929 92.902  1.00 55.57  ? 76  SER L O   1 
ATOM   4741 C CB  . SER C 3 76  ? 121.022 104.682 95.114  1.00 55.57  ? 76  SER L CB  1 
ATOM   4742 O OG  . SER C 3 76  ? 121.129 105.307 96.379  1.00 55.57  ? 76  SER L OG  1 
ATOM   4743 N N   . SER C 3 77  ? 121.358 104.240 92.223  1.00 56.81  ? 77  SER L N   1 
ATOM   4744 C CA  . SER C 3 77  ? 121.180 103.577 90.941  1.00 56.81  ? 77  SER L CA  1 
ATOM   4745 C C   . SER C 3 77  ? 121.422 104.606 89.854  1.00 56.81  ? 77  SER L C   1 
ATOM   4746 O O   . SER C 3 77  ? 120.620 105.526 89.684  1.00 56.81  ? 77  SER L O   1 
ATOM   4747 C CB  . SER C 3 77  ? 119.778 102.979 90.816  1.00 56.81  ? 77  SER L CB  1 
ATOM   4748 O OG  . SER C 3 77  ? 118.797 104.000 90.773  1.00 56.81  ? 77  SER L OG  1 
ATOM   4749 N N   . LEU C 3 78  ? 122.517 104.444 89.118  1.00 54.24  ? 78  LEU L N   1 
ATOM   4750 C CA  . LEU C 3 78  ? 122.972 105.456 88.173  1.00 54.24  ? 78  LEU L CA  1 
ATOM   4751 C C   . LEU C 3 78  ? 122.041 105.456 86.966  1.00 54.24  ? 78  LEU L C   1 
ATOM   4752 O O   . LEU C 3 78  ? 122.210 104.714 85.999  1.00 54.24  ? 78  LEU L O   1 
ATOM   4753 C CB  . LEU C 3 78  ? 124.417 105.195 87.788  1.00 54.24  ? 78  LEU L CB  1 
ATOM   4754 C CG  . LEU C 3 78  ? 125.123 106.258 86.971  1.00 54.24  ? 78  LEU L CG  1 
ATOM   4755 C CD1 . LEU C 3 78  ? 125.121 107.551 87.733  1.00 54.24  ? 78  LEU L CD1 1 
ATOM   4756 C CD2 . LEU C 3 78  ? 126.530 105.811 86.737  1.00 54.24  ? 78  LEU L CD2 1 
ATOM   4757 N N   . GLU C 3 79  ? 121.030 106.315 87.051  1.00 55.82  ? 79  GLU L N   1 
ATOM   4758 C CA  . GLU C 3 79  ? 120.036 106.481 86.006  1.00 55.82  ? 79  GLU L CA  1 
ATOM   4759 C C   . GLU C 3 79  ? 120.685 107.087 84.760  1.00 55.82  ? 79  GLU L C   1 
ATOM   4760 O O   . GLU C 3 79  ? 121.749 107.703 84.858  1.00 55.82  ? 79  GLU L O   1 
ATOM   4761 C CB  . GLU C 3 79  ? 118.913 107.379 86.528  1.00 55.82  ? 79  GLU L CB  1 
ATOM   4762 N N   . PRO C 3 80  ? 120.089 106.912 83.566  1.00 57.30  ? 80  PRO L N   1 
ATOM   4763 C CA  . PRO C 3 80  ? 120.736 107.451 82.358  1.00 57.30  ? 80  PRO L CA  1 
ATOM   4764 C C   . PRO C 3 80  ? 120.734 108.964 82.271  1.00 57.30  ? 80  PRO L C   1 
ATOM   4765 O O   . PRO C 3 80  ? 121.527 109.535 81.511  1.00 57.30  ? 80  PRO L O   1 
ATOM   4766 C CB  . PRO C 3 80  ? 119.915 106.834 81.222  1.00 57.30  ? 80  PRO L CB  1 
ATOM   4767 C CG  . PRO C 3 80  ? 118.606 106.570 81.812  1.00 57.30  ? 80  PRO L CG  1 
ATOM   4768 C CD  . PRO C 3 80  ? 118.879 106.147 83.211  1.00 57.30  ? 80  PRO L CD  1 
ATOM   4769 N N   . GLU C 3 81  ? 119.862 109.636 83.021  1.00 56.83  ? 81  GLU L N   1 
ATOM   4770 C CA  . GLU C 3 81  ? 119.872 111.089 83.048  1.00 56.83  ? 81  GLU L CA  1 
ATOM   4771 C C   . GLU C 3 81  ? 120.907 111.637 84.008  1.00 56.83  ? 81  GLU L C   1 
ATOM   4772 O O   . GLU C 3 81  ? 121.157 112.843 84.003  1.00 56.83  ? 81  GLU L O   1 
ATOM   4773 C CB  . GLU C 3 81  ? 118.492 111.609 83.429  1.00 56.83  ? 81  GLU L CB  1 
ATOM   4774 C CG  . GLU C 3 81  ? 118.064 111.210 84.817  1.00 56.83  ? 81  GLU L CG  1 
ATOM   4775 C CD  . GLU C 3 81  ? 116.649 111.639 85.128  1.00 56.83  ? 81  GLU L CD  1 
ATOM   4776 O OE1 . GLU C 3 81  ? 116.000 112.227 84.239  1.00 56.83  ? 81  GLU L OE1 1 
ATOM   4777 O OE2 . GLU C 3 81  ? 116.182 111.389 86.258  1.00 56.83  ? 81  GLU L OE2 1 
ATOM   4778 N N   . ASP C 3 82  ? 121.522 110.786 84.825  1.00 54.42  ? 82  ASP L N   1 
ATOM   4779 C CA  . ASP C 3 82  ? 122.434 111.276 85.846  1.00 54.42  ? 82  ASP L CA  1 
ATOM   4780 C C   . ASP C 3 82  ? 123.803 111.612 85.293  1.00 54.42  ? 82  ASP L C   1 
ATOM   4781 O O   . ASP C 3 82  ? 124.632 112.154 86.026  1.00 54.42  ? 82  ASP L O   1 
ATOM   4782 C CB  . ASP C 3 82  ? 122.595 110.247 86.954  1.00 54.42  ? 82  ASP L CB  1 
ATOM   4783 C CG  . ASP C 3 82  ? 121.324 110.024 87.727  1.00 54.42  ? 82  ASP L CG  1 
ATOM   4784 O OD1 . ASP C 3 82  ? 120.463 110.926 87.747  1.00 54.42  ? 82  ASP L OD1 1 
ATOM   4785 O OD2 . ASP C 3 82  ? 121.198 108.947 88.338  1.00 54.42  ? 82  ASP L OD2 1 
ATOM   4786 N N   . PHE C 3 83  ? 124.063 111.297 84.033  1.00 52.31  ? 83  PHE L N   1 
ATOM   4787 C CA  . PHE C 3 83  ? 125.390 111.466 83.462  1.00 52.31  ? 83  PHE L CA  1 
ATOM   4788 C C   . PHE C 3 83  ? 125.621 112.929 83.119  1.00 52.31  ? 83  PHE L C   1 
ATOM   4789 O O   . PHE C 3 83  ? 125.088 113.434 82.129  1.00 52.31  ? 83  PHE L O   1 
ATOM   4790 C CB  . PHE C 3 83  ? 125.526 110.567 82.243  1.00 52.31  ? 83  PHE L CB  1 
ATOM   4791 C CG  . PHE C 3 83  ? 125.507 109.103 82.576  1.00 52.31  ? 83  PHE L CG  1 
ATOM   4792 C CD1 . PHE C 3 83  ? 126.655 108.463 83.002  1.00 52.31  ? 83  PHE L CD1 1 
ATOM   4793 C CD2 . PHE C 3 83  ? 124.337 108.376 82.489  1.00 52.31  ? 83  PHE L CD2 1 
ATOM   4794 C CE1 . PHE C 3 83  ? 126.640 107.125 83.315  1.00 52.31  ? 83  PHE L CE1 1 
ATOM   4795 C CE2 . PHE C 3 83  ? 124.317 107.039 82.804  1.00 52.31  ? 83  PHE L CE2 1 
ATOM   4796 C CZ  . PHE C 3 83  ? 125.469 106.414 83.216  1.00 52.31  ? 83  PHE L CZ  1 
ATOM   4797 N N   . ALA C 3 84  ? 126.409 113.608 83.934  1.00 47.73  ? 84  ALA L N   1 
ATOM   4798 C CA  . ALA C 3 84  ? 126.670 115.035 83.794  1.00 47.73  ? 84  ALA L CA  1 
ATOM   4799 C C   . ALA C 3 84  ? 128.006 115.322 84.465  1.00 47.73  ? 84  ALA L C   1 
ATOM   4800 O O   . ALA C 3 84  ? 128.745 114.399 84.821  1.00 47.73  ? 84  ALA L O   1 
ATOM   4801 C CB  . ALA C 3 84  ? 125.534 115.859 84.392  1.00 47.73  ? 84  ALA L CB  1 
ATOM   4802 N N   . VAL C 3 85  ? 128.325 116.594 84.633  1.00 44.83  ? 85  VAL L N   1 
ATOM   4803 C CA  . VAL C 3 85  ? 129.543 117.017 85.311  1.00 44.83  ? 85  VAL L CA  1 
ATOM   4804 C C   . VAL C 3 85  ? 129.165 117.565 86.676  1.00 44.83  ? 85  VAL L C   1 
ATOM   4805 O O   . VAL C 3 85  ? 128.307 118.447 86.782  1.00 44.83  ? 85  VAL L O   1 
ATOM   4806 C CB  . VAL C 3 85  ? 130.302 118.065 84.485  1.00 44.83  ? 85  VAL L CB  1 
ATOM   4807 C CG1 . VAL C 3 85  ? 131.552 118.495 85.205  1.00 44.83  ? 85  VAL L CG1 1 
ATOM   4808 C CG2 . VAL C 3 85  ? 130.638 117.510 83.127  1.00 44.83  ? 85  VAL L CG2 1 
ATOM   4809 N N   . TYR C 3 86  ? 129.798 117.046 87.725  1.00 43.98  ? 86  TYR L N   1 
ATOM   4810 C CA  . TYR C 3 86  ? 129.379 117.315 89.091  1.00 43.98  ? 86  TYR L CA  1 
ATOM   4811 C C   . TYR C 3 86  ? 130.436 118.140 89.795  1.00 43.98  ? 86  TYR L C   1 
ATOM   4812 O O   . TYR C 3 86  ? 131.625 117.865 89.649  1.00 43.98  ? 86  TYR L O   1 
ATOM   4813 C CB  . TYR C 3 86  ? 129.131 116.017 89.849  1.00 43.98  ? 86  TYR L CB  1 
ATOM   4814 C CG  . TYR C 3 86  ? 127.920 115.242 89.385  1.00 43.98  ? 86  TYR L CG  1 
ATOM   4815 C CD1 . TYR C 3 86  ? 126.947 115.832 88.630  1.00 43.98  ? 86  TYR L CD1 1 
ATOM   4816 C CD2 . TYR C 3 86  ? 127.768 113.918 89.707  1.00 43.98  ? 86  TYR L CD2 1 
ATOM   4817 C CE1 . TYR C 3 86  ? 125.876 115.134 88.210  1.00 43.98  ? 86  TYR L CE1 1 
ATOM   4818 C CE2 . TYR C 3 86  ? 126.694 113.217 89.292  1.00 43.98  ? 86  TYR L CE2 1 
ATOM   4819 C CZ  . TYR C 3 86  ? 125.748 113.832 88.543  1.00 43.98  ? 86  TYR L CZ  1 
ATOM   4820 O OH  . TYR C 3 86  ? 124.647 113.138 88.114  1.00 43.98  ? 86  TYR L OH  1 
ATOM   4821 N N   . PHE C 3 87  ? 130.005 119.130 90.575  1.00 42.80  ? 87  PHE L N   1 
ATOM   4822 C CA  . PHE C 3 87  ? 130.896 120.127 91.161  1.00 42.80  ? 87  PHE L CA  1 
ATOM   4823 C C   . PHE C 3 87  ? 130.737 120.202 92.673  1.00 42.80  ? 87  PHE L C   1 
ATOM   4824 O O   . PHE C 3 87  ? 129.642 120.018 93.202  1.00 42.80  ? 87  PHE L O   1 
ATOM   4825 C CB  . PHE C 3 87  ? 130.627 121.517 90.572  1.00 42.80  ? 87  PHE L CB  1 
ATOM   4826 C CG  . PHE C 3 87  ? 131.038 121.670 89.141  1.00 42.80  ? 87  PHE L CG  1 
ATOM   4827 C CD1 . PHE C 3 87  ? 132.323 122.012 88.817  1.00 42.80  ? 87  PHE L CD1 1 
ATOM   4828 C CD2 . PHE C 3 87  ? 130.133 121.467 88.126  1.00 42.80  ? 87  PHE L CD2 1 
ATOM   4829 C CE1 . PHE C 3 87  ? 132.695 122.153 87.514  1.00 42.80  ? 87  PHE L CE1 1 
ATOM   4830 C CE2 . PHE C 3 87  ? 130.508 121.605 86.822  1.00 42.80  ? 87  PHE L CE2 1 
ATOM   4831 C CZ  . PHE C 3 87  ? 131.789 121.950 86.519  1.00 42.80  ? 87  PHE L CZ  1 
ATOM   4832 N N   . CYS C 3 88  ? 131.834 120.487 93.361  1.00 42.34  ? 88  CYS L N   1 
ATOM   4833 C CA  . CYS C 3 88  ? 131.813 120.847 94.767  1.00 42.34  ? 88  CYS L CA  1 
ATOM   4834 C C   . CYS C 3 88  ? 131.807 122.359 94.875  1.00 42.34  ? 88  CYS L C   1 
ATOM   4835 O O   . CYS C 3 88  ? 132.230 123.051 93.952  1.00 42.34  ? 88  CYS L O   1 
ATOM   4836 C CB  . CYS C 3 88  ? 133.043 120.321 95.488  1.00 42.34  ? 88  CYS L CB  1 
ATOM   4837 S SG  . CYS C 3 88  ? 133.278 118.605 95.409  1.00 42.34  ? 88  CYS L SG  1 
ATOM   4838 N N   . GLN C 3 89  ? 131.368 122.877 96.018  1.00 40.83  ? 89  GLN L N   1 
ATOM   4839 C CA  . GLN C 3 89  ? 131.432 124.318 96.227  1.00 40.83  ? 89  GLN L CA  1 
ATOM   4840 C C   . GLN C 3 89  ? 131.589 124.624 97.703  1.00 40.83  ? 89  GLN L C   1 
ATOM   4841 O O   . GLN C 3 89  ? 130.682 124.395 98.502  1.00 40.83  ? 89  GLN L O   1 
ATOM   4842 C CB  . GLN C 3 89  ? 130.206 125.012 95.642  1.00 40.83  ? 89  GLN L CB  1 
ATOM   4843 C CG  . GLN C 3 89  ? 130.241 126.541 95.630  1.00 40.83  ? 89  GLN L CG  1 
ATOM   4844 C CD  . GLN C 3 89  ? 129.348 127.160 96.674  1.00 40.83  ? 89  GLN L CD  1 
ATOM   4845 O OE1 . GLN C 3 89  ? 128.279 126.638 96.965  1.00 40.83  ? 89  GLN L OE1 1 
ATOM   4846 N NE2 . GLN C 3 89  ? 129.778 128.276 97.242  1.00 40.83  ? 89  GLN L NE2 1 
ATOM   4847 N N   . GLN C 3 90  ? 132.757 125.127 98.040  1.00 40.73  ? 90  GLN L N   1 
ATOM   4848 C CA  . GLN C 3 90  ? 133.074 125.598 99.370  1.00 40.73  ? 90  GLN L CA  1 
ATOM   4849 C C   . GLN C 3 90  ? 132.327 126.873 99.704  1.00 40.73  ? 90  GLN L C   1 
ATOM   4850 O O   . GLN C 3 90  ? 132.381 127.853 98.960  1.00 40.73  ? 90  GLN L O   1 
ATOM   4851 C CB  . GLN C 3 90  ? 134.575 125.823 99.439  1.00 40.73  ? 90  GLN L CB  1 
ATOM   4852 C CG  . GLN C 3 90  ? 135.113 126.575 100.588 1.00 40.73  ? 90  GLN L CG  1 
ATOM   4853 C CD  . GLN C 3 90  ? 135.335 128.005 100.222 1.00 40.73  ? 90  GLN L CD  1 
ATOM   4854 O OE1 . GLN C 3 90  ? 135.492 128.327 99.055  1.00 40.73  ? 90  GLN L OE1 1 
ATOM   4855 N NE2 . GLN C 3 90  ? 135.365 128.866 101.199 1.00 40.73  ? 90  GLN L NE2 1 
ATOM   4856 N N   . SER C 3 91  ? 131.652 126.867 100.850 1.00 40.95  ? 91  SER L N   1 
ATOM   4857 C CA  . SER C 3 91  ? 130.977 128.054 101.358 1.00 40.95  ? 91  SER L CA  1 
ATOM   4858 C C   . SER C 3 91  ? 131.469 128.445 102.742 1.00 40.95  ? 91  SER L C   1 
ATOM   4859 O O   . SER C 3 91  ? 130.688 128.936 103.548 1.00 40.95  ? 91  SER L O   1 
ATOM   4860 C CB  . SER C 3 91  ? 129.471 127.843 101.396 1.00 40.95  ? 91  SER L CB  1 
ATOM   4861 O OG  . SER C 3 91  ? 128.851 128.931 102.032 1.00 40.95  ? 91  SER L OG  1 
ATOM   4862 N N   . ASP C 3 92  ? 132.745 128.254 103.028 1.00 42.69  ? 92  ASP L N   1 
ATOM   4863 C CA  . ASP C 3 92  ? 133.244 128.474 104.373 1.00 42.69  ? 92  ASP L CA  1 
ATOM   4864 C C   . ASP C 3 92  ? 133.821 129.870 104.546 1.00 42.69  ? 92  ASP L C   1 
ATOM   4865 O O   . ASP C 3 92  ? 133.810 130.413 105.655 1.00 42.69  ? 92  ASP L O   1 
ATOM   4866 C CB  . ASP C 3 92  ? 134.301 127.427 104.688 1.00 42.69  ? 92  ASP L CB  1 
ATOM   4867 C CG  . ASP C 3 92  ? 134.762 127.468 106.117 1.00 42.69  ? 92  ASP L CG  1 
ATOM   4868 O OD1 . ASP C 3 92  ? 134.028 126.976 106.994 1.00 42.69  ? 92  ASP L OD1 1 
ATOM   4869 O OD2 . ASP C 3 92  ? 135.861 127.992 106.369 1.00 42.69  ? 92  ASP L OD2 1 
ATOM   4870 N N   . ASP C 3 93  ? 134.337 130.460 103.475 1.00 42.09  ? 93  ASP L N   1 
ATOM   4871 C CA  . ASP C 3 93  ? 135.075 131.710 103.556 1.00 42.09  ? 93  ASP L CA  1 
ATOM   4872 C C   . ASP C 3 93  ? 135.075 132.329 102.165 1.00 42.09  ? 93  ASP L C   1 
ATOM   4873 O O   . ASP C 3 93  ? 134.762 131.664 101.178 1.00 42.09  ? 93  ASP L O   1 
ATOM   4874 C CB  . ASP C 3 93  ? 136.490 131.460 104.071 1.00 42.09  ? 93  ASP L CB  1 
ATOM   4875 C CG  . ASP C 3 93  ? 137.153 132.707 104.606 1.00 42.09  ? 93  ASP L CG  1 
ATOM   4876 O OD1 . ASP C 3 93  ? 136.525 133.785 104.584 1.00 42.09  ? 93  ASP L OD1 1 
ATOM   4877 O OD2 . ASP C 3 93  ? 138.311 132.606 105.058 1.00 42.09  ? 93  ASP L OD2 1 
ATOM   4878 N N   . TRP C 3 94  ? 135.402 133.625 102.099 1.00 40.64  ? 94  TRP L N   1 
ATOM   4879 C CA  . TRP C 3 94  ? 135.570 134.214 100.779 1.00 40.64  ? 94  TRP L CA  1 
ATOM   4880 C C   . TRP C 3 94  ? 137.016 134.021 100.326 1.00 40.64  ? 94  TRP L C   1 
ATOM   4881 O O   . TRP C 3 94  ? 137.931 134.097 101.149 1.00 40.64  ? 94  TRP L O   1 
ATOM   4882 C CB  . TRP C 3 94  ? 135.256 135.703 100.789 1.00 40.64  ? 94  TRP L CB  1 
ATOM   4883 C CG  . TRP C 3 94  ? 133.941 136.112 101.380 1.00 40.64  ? 94  TRP L CG  1 
ATOM   4884 C CD1 . TRP C 3 94  ? 133.745 136.621 102.623 1.00 40.64  ? 94  TRP L CD1 1 
ATOM   4885 C CD2 . TRP C 3 94  ? 132.654 136.084 100.757 1.00 40.64  ? 94  TRP L CD2 1 
ATOM   4886 N NE1 . TRP C 3 94  ? 132.425 136.904 102.819 1.00 40.64  ? 94  TRP L NE1 1 
ATOM   4887 C CE2 . TRP C 3 94  ? 131.732 136.583 101.687 1.00 40.64  ? 94  TRP L CE2 1 
ATOM   4888 C CE3 . TRP C 3 94  ? 132.191 135.683 99.511  1.00 40.64  ? 94  TRP L CE3 1 
ATOM   4889 C CZ2 . TRP C 3 94  ? 130.384 136.689 101.412 1.00 40.64  ? 94  TRP L CZ2 1 
ATOM   4890 C CZ3 . TRP C 3 94  ? 130.848 135.789 99.244  1.00 40.64  ? 94  TRP L CZ3 1 
ATOM   4891 C CH2 . TRP C 3 94  ? 129.963 136.287 100.187 1.00 40.64  ? 94  TRP L CH2 1 
ATOM   4892 N N   . PRO C 3 95  ? 137.314 133.770 99.039  1.00 40.21  ? 95  PRO L N   1 
ATOM   4893 C CA  . PRO C 3 95  ? 136.473 133.630 97.850  1.00 40.21  ? 95  PRO L CA  1 
ATOM   4894 C C   . PRO C 3 95  ? 135.675 132.365 97.879  1.00 40.21  ? 95  PRO L C   1 
ATOM   4895 O O   . PRO C 3 95  ? 136.147 131.394 98.446  1.00 40.21  ? 95  PRO L O   1 
ATOM   4896 C CB  . PRO C 3 95  ? 137.485 133.554 96.714  1.00 40.21  ? 95  PRO L CB  1 
ATOM   4897 C CG  . PRO C 3 95  ? 138.712 134.093 97.248  1.00 40.21  ? 95  PRO L CG  1 
ATOM   4898 C CD  . PRO C 3 95  ? 138.735 133.712 98.674  1.00 40.21  ? 95  PRO L CD  1 
ATOM   4899 N N   . LEU C 3 96  ? 134.475 132.370 97.332  1.00 40.52  ? 96  LEU L N   1 
ATOM   4900 C CA  . LEU C 3 96  ? 133.810 131.104 97.120  1.00 40.52  ? 96  LEU L CA  1 
ATOM   4901 C C   . LEU C 3 96  ? 134.581 130.365 96.039  1.00 40.52  ? 96  LEU L C   1 
ATOM   4902 O O   . LEU C 3 96  ? 135.093 130.979 95.108  1.00 40.52  ? 96  LEU L O   1 
ATOM   4903 C CB  . LEU C 3 96  ? 132.356 131.322 96.722  1.00 40.52  ? 96  LEU L CB  1 
ATOM   4904 C CG  . LEU C 3 96  ? 131.546 132.115 97.749  1.00 40.52  ? 96  LEU L CG  1 
ATOM   4905 C CD1 . LEU C 3 96  ? 130.109 132.274 97.304  1.00 40.52  ? 96  LEU L CD1 1 
ATOM   4906 C CD2 . LEU C 3 96  ? 131.618 131.491 99.131  1.00 40.52  ? 96  LEU L CD2 1 
ATOM   4907 N N   . THR C 3 97  ? 134.787 129.065 96.221  1.00 39.29  ? 97  THR L N   1 
ATOM   4908 C CA  . THR C 3 97  ? 135.520 128.289 95.235  1.00 39.29  ? 97  THR L CA  1 
ATOM   4909 C C   . THR C 3 97  ? 134.699 127.082 94.823  1.00 39.29  ? 97  THR L C   1 
ATOM   4910 O O   . THR C 3 97  ? 133.732 126.702 95.480  1.00 39.29  ? 97  THR L O   1 
ATOM   4911 C CB  . THR C 3 97  ? 136.881 127.822 95.748  1.00 39.29  ? 97  THR L CB  1 
ATOM   4912 O OG1 . THR C 3 97  ? 136.695 126.942 96.854  1.00 39.29  ? 97  THR L OG1 1 
ATOM   4913 C CG2 . THR C 3 97  ? 137.741 128.987 96.175  1.00 39.29  ? 97  THR L CG2 1 
ATOM   4914 N N   . PHE C 3 98  ? 135.108 126.488 93.710  1.00 40.77  ? 98  PHE L N   1 
ATOM   4915 C CA  . PHE C 3 98  ? 134.546 125.258 93.190  1.00 40.77  ? 98  PHE L CA  1 
ATOM   4916 C C   . PHE C 3 98  ? 135.644 124.212 93.089  1.00 40.77  ? 98  PHE L C   1 
ATOM   4917 O O   . PHE C 3 98  ? 136.832 124.506 93.218  1.00 40.77  ? 98  PHE L O   1 
ATOM   4918 C CB  . PHE C 3 98  ? 133.914 125.451 91.803  1.00 40.77  ? 98  PHE L CB  1 
ATOM   4919 C CG  . PHE C 3 98  ? 132.573 126.122 91.809  1.00 40.77  ? 98  PHE L CG  1 
ATOM   4920 C CD1 . PHE C 3 98  ? 131.431 125.395 92.031  1.00 40.77  ? 98  PHE L CD1 1 
ATOM   4921 C CD2 . PHE C 3 98  ? 132.454 127.469 91.553  1.00 40.77  ? 98  PHE L CD2 1 
ATOM   4922 C CE1 . PHE C 3 98  ? 130.205 125.997 92.021  1.00 40.77  ? 98  PHE L CE1 1 
ATOM   4923 C CE2 . PHE C 3 98  ? 131.223 128.069 91.540  1.00 40.77  ? 98  PHE L CE2 1 
ATOM   4924 C CZ  . PHE C 3 98  ? 130.102 127.328 91.773  1.00 40.77  ? 98  PHE L CZ  1 
ATOM   4925 N N   . GLY C 3 99  ? 135.229 122.976 92.850  1.00 44.97  ? 99  GLY L N   1 
ATOM   4926 C CA  . GLY C 3 99  ? 136.114 121.930 92.379  1.00 44.97  ? 99  GLY L CA  1 
ATOM   4927 C C   . GLY C 3 99  ? 136.049 121.919 90.866  1.00 44.97  ? 99  GLY L C   1 
ATOM   4928 O O   . GLY C 3 99  ? 135.170 122.544 90.273  1.00 44.97  ? 99  GLY L O   1 
ATOM   4929 N N   . GLN C 3 100 ? 136.983 121.208 90.234  1.00 46.84  ? 100 GLN L N   1 
ATOM   4930 C CA  . GLN C 3 100 ? 137.078 121.277 88.781  1.00 46.84  ? 100 GLN L CA  1 
ATOM   4931 C C   . GLN C 3 100 ? 136.032 120.436 88.081  1.00 46.84  ? 100 GLN L C   1 
ATOM   4932 O O   . GLN C 3 100 ? 135.832 120.598 86.878  1.00 46.84  ? 100 GLN L O   1 
ATOM   4933 C CB  . GLN C 3 100 ? 138.467 120.861 88.319  1.00 46.84  ? 100 GLN L CB  1 
ATOM   4934 C CG  . GLN C 3 100 ? 139.542 121.798 88.799  1.00 46.84  ? 100 GLN L CG  1 
ATOM   4935 C CD  . GLN C 3 100 ? 139.368 123.192 88.245  1.00 46.84  ? 100 GLN L CD  1 
ATOM   4936 O OE1 . GLN C 3 100 ? 139.027 123.370 87.076  1.00 46.84  ? 100 GLN L OE1 1 
ATOM   4937 N NE2 . GLN C 3 100 ? 139.586 124.195 89.087  1.00 46.84  ? 100 GLN L NE2 1 
ATOM   4938 N N   . GLY C 3 101 ? 135.369 119.550 88.785  1.00 44.62  ? 101 GLY L N   1 
ATOM   4939 C CA  . GLY C 3 101 ? 134.333 118.796 88.123  1.00 44.62  ? 101 GLY L CA  1 
ATOM   4940 C C   . GLY C 3 101 ? 134.718 117.349 87.918  1.00 44.62  ? 101 GLY L C   1 
ATOM   4941 O O   . GLY C 3 101 ? 135.896 116.980 87.927  1.00 44.62  ? 101 GLY L O   1 
ATOM   4942 N N   . THR C 3 102 ? 133.707 116.508 87.739  1.00 45.48  ? 102 THR L N   1 
ATOM   4943 C CA  . THR C 3 102 ? 133.888 115.099 87.418  1.00 45.48  ? 102 THR L CA  1 
ATOM   4944 C C   . THR C 3 102 ? 132.875 114.717 86.355  1.00 45.48  ? 102 THR L C   1 
ATOM   4945 O O   . THR C 3 102 ? 131.671 114.698 86.623  1.00 45.48  ? 102 THR L O   1 
ATOM   4946 C CB  . THR C 3 102 ? 133.722 114.224 88.651  1.00 45.48  ? 102 THR L CB  1 
ATOM   4947 O OG1 . THR C 3 102 ? 134.735 114.550 89.606  1.00 45.48  ? 102 THR L OG1 1 
ATOM   4948 C CG2 . THR C 3 102 ? 133.842 112.762 88.276  1.00 45.48  ? 102 THR L CG2 1 
ATOM   4949 N N   . LYS C 3 103 ? 133.359 114.414 85.157  1.00 46.91  ? 103 LYS L N   1 
ATOM   4950 C CA  . LYS C 3 103 ? 132.502 113.931 84.092  1.00 46.91  ? 103 LYS L CA  1 
ATOM   4951 C C   . LYS C 3 103 ? 132.011 112.532 84.416  1.00 46.91  ? 103 LYS L C   1 
ATOM   4952 O O   . LYS C 3 103 ? 132.582 111.827 85.247  1.00 46.91  ? 103 LYS L O   1 
ATOM   4953 C CB  . LYS C 3 103 ? 133.245 113.931 82.761  1.00 46.91  ? 103 LYS L CB  1 
ATOM   4954 N N   . LEU C 3 104 ? 130.943 112.131 83.756  1.00 48.21  ? 104 LEU L N   1 
ATOM   4955 C CA  . LEU C 3 104 ? 130.344 110.860 84.071  1.00 48.21  ? 104 LEU L CA  1 
ATOM   4956 C C   . LEU C 3 104 ? 129.774 110.236 82.809  1.00 48.21  ? 104 LEU L C   1 
ATOM   4957 O O   . LEU C 3 104 ? 128.830 110.775 82.250  1.00 48.21  ? 104 LEU L O   1 
ATOM   4958 C CB  . LEU C 3 104 ? 129.265 111.059 85.119  1.00 48.21  ? 104 LEU L CB  1 
ATOM   4959 C CG  . LEU C 3 104 ? 128.675 109.855 85.831  1.00 48.21  ? 104 LEU L CG  1 
ATOM   4960 C CD1 . LEU C 3 104 ? 129.734 109.238 86.711  1.00 48.21  ? 104 LEU L CD1 1 
ATOM   4961 C CD2 . LEU C 3 104 ? 127.472 110.266 86.646  1.00 48.21  ? 104 LEU L CD2 1 
ATOM   4962 O OXT . LEU C 3 104 ? 130.227 109.208 82.299  1.00 48.21  ? 104 LEU L OXT 1 
ATOM   4963 N N   . ASN D 4 1   ? 139.812 172.927 138.817 1.00 66.74  ? 70  ASN B N   1 
ATOM   4964 C CA  . ASN D 4 1   ? 140.095 171.796 137.944 1.00 66.74  ? 70  ASN B CA  1 
ATOM   4965 C C   . ASN D 4 1   ? 141.234 172.106 136.984 1.00 66.74  ? 70  ASN B C   1 
ATOM   4966 O O   . ASN D 4 1   ? 142.319 171.533 137.094 1.00 66.74  ? 70  ASN B O   1 
ATOM   4967 C CB  . ASN D 4 1   ? 138.846 171.401 137.154 1.00 66.74  ? 70  ASN B CB  1 
ATOM   4968 N N   . GLU D 4 2   ? 140.946 172.987 136.022 1.00 66.64  ? 71  GLU B N   1 
ATOM   4969 C CA  . GLU D 4 2   ? 141.813 173.486 134.953 1.00 66.64  ? 71  GLU B CA  1 
ATOM   4970 C C   . GLU D 4 2   ? 142.234 172.419 133.948 1.00 66.64  ? 71  GLU B C   1 
ATOM   4971 O O   . GLU D 4 2   ? 143.023 172.725 133.048 1.00 66.64  ? 71  GLU B O   1 
ATOM   4972 C CB  . GLU D 4 2   ? 143.075 174.185 135.485 1.00 66.64  ? 71  GLU B CB  1 
ATOM   4973 N N   . ILE D 4 3   ? 141.747 171.182 134.062 1.00 64.88  ? 72  ILE B N   1 
ATOM   4974 C CA  . ILE D 4 3   ? 142.010 170.125 133.095 1.00 64.88  ? 72  ILE B CA  1 
ATOM   4975 C C   . ILE D 4 3   ? 140.716 169.502 132.589 1.00 64.88  ? 72  ILE B C   1 
ATOM   4976 O O   . ILE D 4 3   ? 140.489 169.409 131.379 1.00 64.88  ? 72  ILE B O   1 
ATOM   4977 C CB  . ILE D 4 3   ? 142.941 169.043 133.682 1.00 64.88  ? 72  ILE B CB  1 
ATOM   4978 C CG1 . ILE D 4 3   ? 144.314 169.627 134.012 1.00 64.88  ? 72  ILE B CG1 1 
ATOM   4979 C CG2 . ILE D 4 3   ? 143.097 167.894 132.710 1.00 64.88  ? 72  ILE B CG2 1 
ATOM   4980 C CD1 . ILE D 4 3   ? 145.188 168.703 134.832 1.00 64.88  ? 72  ILE B CD1 1 
ATOM   4981 N N   . ASN D 4 4   ? 139.847 169.080 133.503 1.00 59.42  ? 73  ASN B N   1 
ATOM   4982 C CA  . ASN D 4 4   ? 138.627 168.388 133.119 1.00 59.42  ? 73  ASN B CA  1 
ATOM   4983 C C   . ASN D 4 4   ? 137.606 169.374 132.590 1.00 59.42  ? 73  ASN B C   1 
ATOM   4984 O O   . ASN D 4 4   ? 137.367 170.419 133.193 1.00 59.42  ? 73  ASN B O   1 
ATOM   4985 C CB  . ASN D 4 4   ? 138.043 167.637 134.306 1.00 59.42  ? 73  ASN B CB  1 
ATOM   4986 C CG  . ASN D 4 4   ? 138.926 166.519 134.773 1.00 59.42  ? 73  ASN B CG  1 
ATOM   4987 O OD1 . ASN D 4 4   ? 139.537 165.820 133.970 1.00 59.42  ? 73  ASN B OD1 1 
ATOM   4988 N ND2 . ASN D 4 4   ? 138.993 166.330 136.082 1.00 59.42  ? 73  ASN B ND2 1 
ATOM   4989 N N   . THR D 4 5   ? 136.999 169.040 131.467 1.00 57.85  ? 74  THR B N   1 
ATOM   4990 C CA  . THR D 4 5   ? 135.991 169.904 130.880 1.00 57.85  ? 74  THR B CA  1 
ATOM   4991 C C   . THR D 4 5   ? 134.585 169.557 131.327 1.00 57.85  ? 74  THR B C   1 
ATOM   4992 O O   . THR D 4 5   ? 133.648 170.304 131.026 1.00 57.85  ? 74  THR B O   1 
ATOM   4993 C CB  . THR D 4 5   ? 136.062 169.835 129.355 1.00 57.85  ? 74  THR B CB  1 
ATOM   4994 O OG1 . THR D 4 5   ? 135.100 170.734 128.790 1.00 57.85  ? 74  THR B OG1 1 
ATOM   4995 C CG2 . THR D 4 5   ? 135.787 168.422 128.869 1.00 57.85  ? 74  THR B CG2 1 
ATOM   4996 N N   . GLN D 4 6   ? 134.411 168.442 132.030 1.00 54.34  ? 75  GLN B N   1 
ATOM   4997 C CA  . GLN D 4 6   ? 133.080 167.975 132.385 1.00 54.34  ? 75  GLN B CA  1 
ATOM   4998 C C   . GLN D 4 6   ? 132.840 168.041 133.884 1.00 54.34  ? 75  GLN B C   1 
ATOM   4999 O O   . GLN D 4 6   ? 131.809 168.552 134.327 1.00 54.34  ? 75  GLN B O   1 
ATOM   5000 C CB  . GLN D 4 6   ? 132.890 166.553 131.872 1.00 54.34  ? 75  GLN B CB  1 
ATOM   5001 C CG  . GLN D 4 6   ? 133.014 166.484 130.387 1.00 54.34  ? 75  GLN B CG  1 
ATOM   5002 C CD  . GLN D 4 6   ? 133.159 165.084 129.880 1.00 54.34  ? 75  GLN B CD  1 
ATOM   5003 O OE1 . GLN D 4 6   ? 133.064 164.122 130.635 1.00 54.34  ? 75  GLN B OE1 1 
ATOM   5004 N NE2 . GLN D 4 6   ? 133.485 164.960 128.613 1.00 54.34  ? 75  GLN B NE2 1 
ATOM   5005 N N   . VAL D 4 7   ? 133.772 167.537 134.675 1.00 55.56  ? 76  VAL B N   1 
ATOM   5006 C CA  . VAL D 4 7   ? 133.628 167.517 136.119 1.00 55.56  ? 76  VAL B CA  1 
ATOM   5007 C C   . VAL D 4 7   ? 134.565 168.542 136.732 1.00 55.56  ? 76  VAL B C   1 
ATOM   5008 O O   . VAL D 4 7   ? 135.762 168.574 136.436 1.00 55.56  ? 76  VAL B O   1 
ATOM   5009 C CB  . VAL D 4 7   ? 133.855 166.105 136.675 1.00 55.56  ? 76  VAL B CB  1 
ATOM   5010 C CG1 . VAL D 4 7   ? 132.718 165.255 136.240 1.00 55.56  ? 76  VAL B CG1 1 
ATOM   5011 C CG2 . VAL D 4 7   ? 135.113 165.485 136.126 1.00 55.56  ? 76  VAL B CG2 1 
ATOM   5012 N N   . THR D 4 8   ? 134.006 169.428 137.541 1.00 57.59  ? 77  THR B N   1 
ATOM   5013 C CA  . THR D 4 8   ? 134.780 170.465 138.164 1.00 57.59  ? 77  THR B CA  1 
ATOM   5014 C C   . THR D 4 8   ? 134.433 170.464 139.641 1.00 57.59  ? 77  THR B C   1 
ATOM   5015 O O   . THR D 4 8   ? 133.249 170.407 139.993 1.00 57.59  ? 77  THR B O   1 
ATOM   5016 C CB  . THR D 4 8   ? 134.499 171.849 137.565 1.00 57.59  ? 77  THR B CB  1 
ATOM   5017 O OG1 . THR D 4 8   ? 133.095 172.124 137.631 1.00 57.59  ? 77  THR B OG1 1 
ATOM   5018 C CG2 . THR D 4 8   ? 134.982 171.946 136.119 1.00 57.59  ? 77  THR B CG2 1 
ATOM   5019 N N   . PRO D 4 9   ? 135.428 170.526 140.530 1.00 59.28  ? 78  PRO B N   1 
ATOM   5020 C CA  . PRO D 4 9   ? 136.863 170.576 140.267 1.00 59.28  ? 78  PRO B CA  1 
ATOM   5021 C C   . PRO D 4 9   ? 137.462 169.202 140.047 1.00 59.28  ? 78  PRO B C   1 
ATOM   5022 O O   . PRO D 4 9   ? 136.763 168.204 140.158 1.00 59.28  ? 78  PRO B O   1 
ATOM   5023 C CB  . PRO D 4 9   ? 137.418 171.198 141.538 1.00 59.28  ? 78  PRO B CB  1 
ATOM   5024 C CG  . PRO D 4 9   ? 136.490 170.760 142.576 1.00 59.28  ? 78  PRO B CG  1 
ATOM   5025 C CD  . PRO D 4 9   ? 135.138 170.731 141.954 1.00 59.28  ? 78  PRO B CD  1 
ATOM   5026 N N   . GLY D 4 10  ? 138.749 169.156 139.739 1.00 63.60  ? 79  GLY B N   1 
ATOM   5027 C CA  . GLY D 4 10  ? 139.395 167.899 139.445 1.00 63.60  ? 79  GLY B CA  1 
ATOM   5028 C C   . GLY D 4 10  ? 140.291 167.417 140.559 1.00 63.60  ? 79  GLY B C   1 
ATOM   5029 O O   . GLY D 4 10  ? 140.657 166.242 140.596 1.00 63.60  ? 79  GLY B O   1 
ATOM   5030 N N   . GLU D 4 11  ? 140.663 168.310 141.469 1.00 67.58  ? 80  GLU B N   1 
ATOM   5031 C CA  . GLU D 4 11  ? 141.561 167.946 142.557 1.00 67.58  ? 80  GLU B CA  1 
ATOM   5032 C C   . GLU D 4 11  ? 141.324 168.875 143.734 1.00 67.58  ? 80  GLU B C   1 
ATOM   5033 O O   . GLU D 4 11  ? 141.628 170.066 143.647 1.00 67.58  ? 80  GLU B O   1 
ATOM   5034 C CB  . GLU D 4 11  ? 143.020 168.015 142.108 1.00 67.58  ? 80  GLU B CB  1 
ATOM   5035 N N   . VAL D 4 12  ? 140.794 168.337 144.829 1.00 72.66  ? 81  VAL B N   1 
ATOM   5036 C CA  . VAL D 4 12  ? 140.590 169.097 146.054 1.00 72.66  ? 81  VAL B CA  1 
ATOM   5037 C C   . VAL D 4 12  ? 141.281 168.361 147.193 1.00 72.66  ? 81  VAL B C   1 
ATOM   5038 O O   . VAL D 4 12  ? 141.245 167.128 147.262 1.00 72.66  ? 81  VAL B O   1 
ATOM   5039 C CB  . VAL D 4 12  ? 139.092 169.350 146.331 1.00 72.66  ? 81  VAL B CB  1 
ATOM   5040 C CG1 . VAL D 4 12  ? 138.305 168.071 146.510 1.00 72.66  ? 81  VAL B CG1 1 
ATOM   5041 C CG2 . VAL D 4 12  ? 138.899 170.273 147.526 1.00 72.66  ? 81  VAL B CG2 1 
ATOM   5042 N N   . SER D 4 13  ? 141.982 169.113 148.035 1.00 78.18  ? 82  SER B N   1 
ATOM   5043 C CA  . SER D 4 13  ? 142.727 168.563 149.157 1.00 78.18  ? 82  SER B CA  1 
ATOM   5044 C C   . SER D 4 13  ? 142.031 168.970 150.446 1.00 78.18  ? 82  SER B C   1 
ATOM   5045 O O   . SER D 4 13  ? 141.835 170.162 150.699 1.00 78.18  ? 82  SER B O   1 
ATOM   5046 C CB  . SER D 4 13  ? 144.173 169.052 149.142 1.00 78.18  ? 82  SER B CB  1 
ATOM   5047 O OG  . SER D 4 13  ? 144.236 170.451 149.350 1.00 78.18  ? 82  SER B OG  1 
ATOM   5048 N N   . ILE D 4 14  ? 141.653 167.983 151.250 1.00 78.91  ? 83  ILE B N   1 
ATOM   5049 C CA  . ILE D 4 14  ? 140.867 168.196 152.456 1.00 78.91  ? 83  ILE B CA  1 
ATOM   5050 C C   . ILE D 4 14  ? 141.646 167.646 153.639 1.00 78.91  ? 83  ILE B C   1 
ATOM   5051 O O   . ILE D 4 14  ? 141.988 166.460 153.659 1.00 78.91  ? 83  ILE B O   1 
ATOM   5052 C CB  . ILE D 4 14  ? 139.494 167.515 152.356 1.00 78.91  ? 83  ILE B CB  1 
ATOM   5053 C CG1 . ILE D 4 14  ? 138.705 168.060 151.172 1.00 78.91  ? 83  ILE B CG1 1 
ATOM   5054 C CG2 . ILE D 4 14  ? 138.714 167.731 153.619 1.00 78.91  ? 83  ILE B CG2 1 
ATOM   5055 C CD1 . ILE D 4 14  ? 137.482 167.250 150.851 1.00 78.91  ? 83  ILE B CD1 1 
ATOM   5056 N N   . GLN D 4 15  ? 141.914 168.497 154.627 1.00 81.19  ? 84  GLN B N   1 
ATOM   5057 C CA  . GLN D 4 15  ? 142.583 168.097 155.860 1.00 81.19  ? 84  GLN B CA  1 
ATOM   5058 C C   . GLN D 4 15  ? 141.545 168.035 156.968 1.00 81.19  ? 84  GLN B C   1 
ATOM   5059 O O   . GLN D 4 15  ? 140.805 168.999 157.179 1.00 81.19  ? 84  GLN B O   1 
ATOM   5060 C CB  . GLN D 4 15  ? 143.699 169.074 156.220 1.00 81.19  ? 84  GLN B CB  1 
ATOM   5061 N N   . LEU D 4 16  ? 141.482 166.908 157.669 1.00 85.10  ? 85  LEU B N   1 
ATOM   5062 C CA  . LEU D 4 16  ? 140.461 166.685 158.683 1.00 85.10  ? 85  LEU B CA  1 
ATOM   5063 C C   . LEU D 4 16  ? 141.055 166.133 159.975 1.00 85.10  ? 85  LEU B C   1 
ATOM   5064 O O   . LEU D 4 16  ? 141.811 165.157 159.955 1.00 85.10  ? 85  LEU B O   1 
ATOM   5065 C CB  . LEU D 4 16  ? 139.385 165.727 158.174 1.00 85.10  ? 85  LEU B CB  1 
ATOM   5066 C CG  . LEU D 4 16  ? 138.493 166.241 157.056 1.00 85.10  ? 85  LEU B CG  1 
ATOM   5067 C CD1 . LEU D 4 16  ? 137.536 165.156 156.606 1.00 85.10  ? 85  LEU B CD1 1 
ATOM   5068 C CD2 . LEU D 4 16  ? 137.746 167.464 157.525 1.00 85.10  ? 85  LEU B CD2 1 
ATOM   5069 N N   . ARG D 4 17  ? 140.704 166.770 161.083 1.00 89.50  ? 86  ARG B N   1 
ATOM   5070 C CA  . ARG D 4 17  ? 140.758 166.198 162.421 1.00 89.50  ? 86  ARG B CA  1 
ATOM   5071 C C   . ARG D 4 17  ? 139.419 165.536 162.715 1.00 89.50  ? 86  ARG B C   1 
ATOM   5072 O O   . ARG D 4 17  ? 138.376 166.052 162.310 1.00 89.50  ? 86  ARG B O   1 
ATOM   5073 C CB  . ARG D 4 17  ? 141.080 167.312 163.419 1.00 89.50  ? 86  ARG B CB  1 
ATOM   5074 N N   . PRO D 4 18  ? 139.410 164.360 163.362 1.00 88.87  ? 87  PRO B N   1 
ATOM   5075 C CA  . PRO D 4 18  ? 138.156 163.603 163.511 1.00 88.87  ? 87  PRO B CA  1 
ATOM   5076 C C   . PRO D 4 18  ? 137.110 164.303 164.360 1.00 88.87  ? 87  PRO B C   1 
ATOM   5077 O O   . PRO D 4 18  ? 137.421 165.130 165.218 1.00 88.87  ? 87  PRO B O   1 
ATOM   5078 C CB  . PRO D 4 18  ? 138.610 162.299 164.171 1.00 88.87  ? 87  PRO B CB  1 
ATOM   5079 C CG  . PRO D 4 18  ? 139.996 162.136 163.722 1.00 88.87  ? 87  PRO B CG  1 
ATOM   5080 C CD  . PRO D 4 18  ? 140.577 163.511 163.652 1.00 88.87  ? 87  PRO B CD  1 
ATOM   5081 N N   . GLY D 4 19  ? 135.854 163.958 164.097 1.00 86.52  ? 88  GLY B N   1 
ATOM   5082 C CA  . GLY D 4 19  ? 134.733 164.655 164.704 1.00 86.52  ? 88  GLY B CA  1 
ATOM   5083 C C   . GLY D 4 19  ? 134.398 165.959 164.016 1.00 86.52  ? 88  GLY B C   1 
ATOM   5084 O O   . GLY D 4 19  ? 133.733 166.819 164.607 1.00 86.52  ? 88  GLY B O   1 
ATOM   5085 N N   . ALA D 4 20  ? 134.840 166.125 162.773 1.00 84.05  ? 89  ALA B N   1 
ATOM   5086 C CA  . ALA D 4 20  ? 134.614 167.345 162.016 1.00 84.05  ? 89  ALA B CA  1 
ATOM   5087 C C   . ALA D 4 20  ? 134.210 166.995 160.594 1.00 84.05  ? 89  ALA B C   1 
ATOM   5088 O O   . ALA D 4 20  ? 134.730 166.052 159.996 1.00 84.05  ? 89  ALA B O   1 
ATOM   5089 C CB  . ALA D 4 20  ? 135.859 168.236 161.999 1.00 84.05  ? 89  ALA B CB  1 
ATOM   5090 N N   . GLU D 4 21  ? 133.279 167.773 160.056 1.00 77.48  ? 90  GLU B N   1 
ATOM   5091 C CA  . GLU D 4 21  ? 132.692 167.511 158.754 1.00 77.48  ? 90  GLU B CA  1 
ATOM   5092 C C   . GLU D 4 21  ? 133.168 168.550 157.757 1.00 77.48  ? 90  GLU B C   1 
ATOM   5093 O O   . GLU D 4 21  ? 133.139 169.751 158.038 1.00 77.48  ? 90  GLU B O   1 
ATOM   5094 C CB  . GLU D 4 21  ? 131.165 167.526 158.823 1.00 77.48  ? 90  GLU B CB  1 
ATOM   5095 N N   . ALA D 4 22  ? 133.604 168.078 156.591 1.00 72.70  ? 91  ALA B N   1 
ATOM   5096 C CA  . ALA D 4 22  ? 133.963 168.938 155.477 1.00 72.70  ? 91  ALA B CA  1 
ATOM   5097 C C   . ALA D 4 22  ? 132.893 168.821 154.412 1.00 72.70  ? 91  ALA B C   1 
ATOM   5098 O O   . ALA D 4 22  ? 132.099 167.881 154.413 1.00 72.70  ? 91  ALA B O   1 
ATOM   5099 C CB  . ALA D 4 22  ? 135.321 168.584 154.891 1.00 72.70  ? 91  ALA B CB  1 
ATOM   5100 N N   . ASN D 4 23  ? 132.870 169.792 153.510 1.00 67.01  ? 92  ASN B N   1 
ATOM   5101 C CA  . ASN D 4 23  ? 131.746 169.977 152.612 1.00 67.01  ? 92  ASN B CA  1 
ATOM   5102 C C   . ASN D 4 23  ? 132.200 170.731 151.376 1.00 67.01  ? 92  ASN B C   1 
ATOM   5103 O O   . ASN D 4 23  ? 132.859 171.767 151.491 1.00 67.01  ? 92  ASN B O   1 
ATOM   5104 C CB  . ASN D 4 23  ? 130.646 170.744 153.328 1.00 67.01  ? 92  ASN B CB  1 
ATOM   5105 C CG  . ASN D 4 23  ? 129.334 170.680 152.615 1.00 67.01  ? 92  ASN B CG  1 
ATOM   5106 O OD1 . ASN D 4 23  ? 129.199 170.034 151.585 1.00 67.01  ? 92  ASN B OD1 1 
ATOM   5107 N ND2 . ASN D 4 23  ? 128.349 171.359 153.161 1.00 67.01  ? 92  ASN B ND2 1 
ATOM   5108 N N   . PHE D 4 24  ? 131.839 170.222 150.201 1.00 65.83  ? 93  PHE B N   1 
ATOM   5109 C CA  . PHE D 4 24  ? 132.124 170.888 148.939 1.00 65.83  ? 93  PHE B CA  1 
ATOM   5110 C C   . PHE D 4 24  ? 131.119 170.426 147.901 1.00 65.83  ? 93  PHE B C   1 
ATOM   5111 O O   . PHE D 4 24  ? 130.548 169.342 148.018 1.00 65.83  ? 93  PHE B O   1 
ATOM   5112 C CB  . PHE D 4 24  ? 133.549 170.613 148.452 1.00 65.83  ? 93  PHE B CB  1 
ATOM   5113 C CG  . PHE D 4 24  ? 133.821 169.176 148.106 1.00 65.83  ? 93  PHE B CG  1 
ATOM   5114 C CD1 . PHE D 4 24  ? 134.197 168.275 149.085 1.00 65.83  ? 93  PHE B CD1 1 
ATOM   5115 C CD2 . PHE D 4 24  ? 133.773 168.744 146.790 1.00 65.83  ? 93  PHE B CD2 1 
ATOM   5116 C CE1 . PHE D 4 24  ? 134.466 166.960 148.766 1.00 65.83  ? 93  PHE B CE1 1 
ATOM   5117 C CE2 . PHE D 4 24  ? 134.038 167.434 146.465 1.00 65.83  ? 93  PHE B CE2 1 
ATOM   5118 C CZ  . PHE D 4 24  ? 134.391 166.542 147.451 1.00 65.83  ? 93  PHE B CZ  1 
ATOM   5119 N N   . MET D 4 25  ? 130.913 171.243 146.874 1.00 62.44  ? 94  MET B N   1 
ATOM   5120 C CA  . MET D 4 25  ? 130.016 170.886 145.787 1.00 62.44  ? 94  MET B CA  1 
ATOM   5121 C C   . MET D 4 25  ? 130.829 170.645 144.534 1.00 62.44  ? 94  MET B C   1 
ATOM   5122 O O   . MET D 4 25  ? 131.812 171.345 144.283 1.00 62.44  ? 94  MET B O   1 
ATOM   5123 C CB  . MET D 4 25  ? 128.971 171.963 145.533 1.00 62.44  ? 94  MET B CB  1 
ATOM   5124 C CG  . MET D 4 25  ? 128.113 172.205 146.737 1.00 62.44  ? 94  MET B CG  1 
ATOM   5125 S SD  . MET D 4 25  ? 126.750 173.307 146.407 1.00 62.44  ? 94  MET B SD  1 
ATOM   5126 C CE  . MET D 4 25  ? 125.714 172.164 145.525 1.00 62.44  ? 94  MET B CE  1 
ATOM   5127 N N   . LEU D 4 26  ? 130.418 169.651 143.761 1.00 57.01  ? 95  LEU B N   1 
ATOM   5128 C CA  . LEU D 4 26  ? 131.111 169.255 142.552 1.00 57.01  ? 95  LEU B CA  1 
ATOM   5129 C C   . LEU D 4 26  ? 130.120 169.310 141.405 1.00 57.01  ? 95  LEU B C   1 
ATOM   5130 O O   . LEU D 4 26  ? 129.106 168.613 141.425 1.00 57.01  ? 95  LEU B O   1 
ATOM   5131 C CB  . LEU D 4 26  ? 131.691 167.856 142.718 1.00 57.01  ? 95  LEU B CB  1 
ATOM   5132 C CG  . LEU D 4 26  ? 132.801 167.365 141.799 1.00 57.01  ? 95  LEU B CG  1 
ATOM   5133 C CD1 . LEU D 4 26  ? 133.637 166.418 142.609 1.00 57.01  ? 95  LEU B CD1 1 
ATOM   5134 C CD2 . LEU D 4 26  ? 132.275 166.669 140.556 1.00 57.01  ? 95  LEU B CD2 1 
ATOM   5135 N N   . LYS D 4 27  ? 130.409 170.143 140.416 1.00 54.46  ? 96  LYS B N   1 
ATOM   5136 C CA  . LYS D 4 27  ? 129.518 170.375 139.291 1.00 54.46  ? 96  LYS B CA  1 
ATOM   5137 C C   . LYS D 4 27  ? 129.877 169.430 138.160 1.00 54.46  ? 96  LYS B C   1 
ATOM   5138 O O   . LYS D 4 27  ? 131.054 169.262 137.839 1.00 54.46  ? 96  LYS B O   1 
ATOM   5139 C CB  . LYS D 4 27  ? 129.609 171.824 138.809 1.00 54.46  ? 96  LYS B CB  1 
ATOM   5140 N N   . VAL D 4 28  ? 128.872 168.811 137.567 1.00 54.59  ? 97  VAL B N   1 
ATOM   5141 C CA  . VAL D 4 28  ? 129.052 167.977 136.390 1.00 54.59  ? 97  VAL B CA  1 
ATOM   5142 C C   . VAL D 4 28  ? 128.399 168.687 135.218 1.00 54.59  ? 97  VAL B C   1 
ATOM   5143 O O   . VAL D 4 28  ? 127.176 168.864 135.192 1.00 54.59  ? 97  VAL B O   1 
ATOM   5144 C CB  . VAL D 4 28  ? 128.453 166.579 136.582 1.00 54.59  ? 97  VAL B CB  1 
ATOM   5145 C CG1 . VAL D 4 28  ? 128.502 165.837 135.290 1.00 54.59  ? 97  VAL B CG1 1 
ATOM   5146 C CG2 . VAL D 4 28  ? 129.218 165.824 137.644 1.00 54.59  ? 97  VAL B CG2 1 
ATOM   5147 N N   . HIS D 4 29  ? 129.210 169.097 134.250 1.00 54.48  ? 98  HIS B N   1 
ATOM   5148 C CA  . HIS D 4 29  ? 128.698 169.793 133.077 1.00 54.48  ? 98  HIS B CA  1 
ATOM   5149 C C   . HIS D 4 29  ? 128.871 168.902 131.859 1.00 54.48  ? 98  HIS B C   1 
ATOM   5150 O O   . HIS D 4 29  ? 130.004 168.696 131.404 1.00 54.48  ? 98  HIS B O   1 
ATOM   5151 C CB  . HIS D 4 29  ? 129.428 171.122 132.882 1.00 54.48  ? 98  HIS B CB  1 
ATOM   5152 C CG  . HIS D 4 29  ? 128.758 172.037 131.914 1.00 54.48  ? 98  HIS B CG  1 
ATOM   5153 N ND1 . HIS D 4 29  ? 129.365 173.168 131.418 1.00 54.48  ? 98  HIS B ND1 1 
ATOM   5154 C CD2 . HIS D 4 29  ? 127.528 171.994 131.357 1.00 54.48  ? 98  HIS B CD2 1 
ATOM   5155 C CE1 . HIS D 4 29  ? 128.538 173.781 130.592 1.00 54.48  ? 98  HIS B CE1 1 
ATOM   5156 N NE2 . HIS D 4 29  ? 127.416 173.088 130.537 1.00 54.48  ? 98  HIS B NE2 1 
ATOM   5157 N N   . PRO D 4 30  ? 127.803 168.332 131.317 1.00 51.71  ? 99  PRO B N   1 
ATOM   5158 C CA  . PRO D 4 30  ? 127.941 167.491 130.130 1.00 51.71  ? 99  PRO B CA  1 
ATOM   5159 C C   . PRO D 4 30  ? 128.324 168.302 128.905 1.00 51.71  ? 99  PRO B C   1 
ATOM   5160 O O   . PRO D 4 30  ? 128.042 169.496 128.801 1.00 51.71  ? 99  PRO B O   1 
ATOM   5161 C CB  . PRO D 4 30  ? 126.546 166.880 129.969 1.00 51.71  ? 99  PRO B CB  1 
ATOM   5162 C CG  . PRO D 4 30  ? 125.954 166.954 131.298 1.00 51.71  ? 99  PRO B CG  1 
ATOM   5163 C CD  . PRO D 4 30  ? 126.468 168.207 131.909 1.00 51.71  ? 99  PRO B CD  1 
ATOM   5164 N N   . LEU D 4 31  ? 128.996 167.639 127.975 1.00 48.45  ? 100 LEU B N   1 
ATOM   5165 C CA  . LEU D 4 31  ? 129.293 168.224 126.682 1.00 48.45  ? 100 LEU B CA  1 
ATOM   5166 C C   . LEU D 4 31  ? 128.148 167.951 125.723 1.00 48.45  ? 100 LEU B C   1 
ATOM   5167 O O   . LEU D 4 31  ? 127.343 167.043 125.918 1.00 48.45  ? 100 LEU B O   1 
ATOM   5168 C CB  . LEU D 4 31  ? 130.587 167.656 126.100 1.00 48.45  ? 100 LEU B CB  1 
ATOM   5169 C CG  . LEU D 4 31  ? 131.907 167.866 126.816 1.00 48.45  ? 100 LEU B CG  1 
ATOM   5170 C CD1 . LEU D 4 31  ? 132.985 167.162 126.045 1.00 48.45  ? 100 LEU B CD1 1 
ATOM   5171 C CD2 . LEU D 4 31  ? 132.217 169.330 126.944 1.00 48.45  ? 100 LEU B CD2 1 
ATOM   5172 N N   . LYS D 4 32  ? 128.081 168.757 124.679 1.00 47.33  ? 101 LYS B N   1 
ATOM   5173 C CA  . LYS D 4 32  ? 127.307 168.415 123.502 1.00 47.33  ? 101 LYS B CA  1 
ATOM   5174 C C   . LYS D 4 32  ? 128.258 167.801 122.494 1.00 47.33  ? 101 LYS B C   1 
ATOM   5175 O O   . LYS D 4 32  ? 129.417 168.215 122.407 1.00 47.33  ? 101 LYS B O   1 
ATOM   5176 C CB  . LYS D 4 32  ? 126.627 169.638 122.898 1.00 47.33  ? 101 LYS B CB  1 
ATOM   5177 N N   . LYS D 4 33  ? 127.764 166.804 121.755 1.00 44.76  ? 102 LYS B N   1 
ATOM   5178 C CA  . LYS D 4 33  ? 128.460 166.161 120.639 1.00 44.76  ? 102 LYS B CA  1 
ATOM   5179 C C   . LYS D 4 33  ? 129.777 165.520 121.098 1.00 44.76  ? 102 LYS B C   1 
ATOM   5180 O O   . LYS D 4 33  ? 130.869 166.019 120.844 1.00 44.76  ? 102 LYS B O   1 
ATOM   5181 C CB  . LYS D 4 33  ? 128.693 167.151 119.491 1.00 44.76  ? 102 LYS B CB  1 
ATOM   5182 C CG  . LYS D 4 33  ? 127.458 167.924 119.085 1.00 44.76  ? 102 LYS B CG  1 
ATOM   5183 C CD  . LYS D 4 33  ? 126.372 167.031 118.580 1.00 44.76  ? 102 LYS B CD  1 
ATOM   5184 C CE  . LYS D 4 33  ? 126.738 166.479 117.227 1.00 44.76  ? 102 LYS B CE  1 
ATOM   5185 N NZ  . LYS D 4 33  ? 126.811 167.559 116.212 1.00 44.76  ? 102 LYS B NZ  1 
ATOM   5186 N N   . TYR D 4 34  ? 129.634 164.426 121.843 1.00 43.67  ? 103 TYR B N   1 
ATOM   5187 C CA  . TYR D 4 34  ? 130.768 163.572 122.167 1.00 43.67  ? 103 TYR B CA  1 
ATOM   5188 C C   . TYR D 4 34  ? 131.266 162.805 120.944 1.00 43.67  ? 103 TYR B C   1 
ATOM   5189 O O   . TYR D 4 34  ? 130.525 162.602 119.983 1.00 43.67  ? 103 TYR B O   1 
ATOM   5190 C CB  . TYR D 4 34  ? 130.377 162.561 123.238 1.00 43.67  ? 103 TYR B CB  1 
ATOM   5191 C CG  . TYR D 4 34  ? 130.270 163.097 124.637 1.00 43.67  ? 103 TYR B CG  1 
ATOM   5192 C CD1 . TYR D 4 34  ? 131.382 163.185 125.440 1.00 43.67  ? 103 TYR B CD1 1 
ATOM   5193 C CD2 . TYR D 4 34  ? 129.055 163.499 125.155 1.00 43.67  ? 103 TYR B CD2 1 
ATOM   5194 C CE1 . TYR D 4 34  ? 131.288 163.651 126.703 1.00 43.67  ? 103 TYR B CE1 1 
ATOM   5195 C CE2 . TYR D 4 34  ? 128.960 163.973 126.430 1.00 43.67  ? 103 TYR B CE2 1 
ATOM   5196 C CZ  . TYR D 4 34  ? 130.084 164.047 127.196 1.00 43.67  ? 103 TYR B CZ  1 
ATOM   5197 O OH  . TYR D 4 34  ? 130.008 164.520 128.478 1.00 43.67  ? 103 TYR B OH  1 
ATOM   5198 N N   . PRO D 4 35  ? 132.521 162.365 120.959 1.00 39.92  ? 104 PRO B N   1 
ATOM   5199 C CA  . PRO D 4 35  ? 132.924 161.260 120.094 1.00 39.92  ? 104 PRO B CA  1 
ATOM   5200 C C   . PRO D 4 35  ? 132.412 159.948 120.660 1.00 39.92  ? 104 PRO B C   1 
ATOM   5201 O O   . PRO D 4 35  ? 132.364 159.748 121.871 1.00 39.92  ? 104 PRO B O   1 
ATOM   5202 C CB  . PRO D 4 35  ? 134.448 161.316 120.139 1.00 39.92  ? 104 PRO B CB  1 
ATOM   5203 C CG  . PRO D 4 35  ? 134.763 162.653 120.595 1.00 39.92  ? 104 PRO B CG  1 
ATOM   5204 C CD  . PRO D 4 35  ? 133.691 163.028 121.539 1.00 39.92  ? 104 PRO B CD  1 
ATOM   5205 N N   . VAL D 4 36  ? 132.016 159.043 119.773 1.00 38.72  ? 105 VAL B N   1 
ATOM   5206 C CA  . VAL D 4 36  ? 131.350 157.809 120.176 1.00 38.72  ? 105 VAL B CA  1 
ATOM   5207 C C   . VAL D 4 36  ? 132.082 156.612 119.588 1.00 38.72  ? 105 VAL B C   1 
ATOM   5208 O O   . VAL D 4 36  ? 132.295 156.545 118.375 1.00 38.72  ? 105 VAL B O   1 
ATOM   5209 C CB  . VAL D 4 36  ? 129.870 157.807 119.749 1.00 38.72  ? 105 VAL B CB  1 
ATOM   5210 C CG1 . VAL D 4 36  ? 129.249 156.447 119.940 1.00 38.72  ? 105 VAL B CG1 1 
ATOM   5211 C CG2 . VAL D 4 36  ? 129.096 158.814 120.559 1.00 38.72  ? 105 VAL B CG2 1 
ATOM   5212 N N   . ASP D 4 37  ? 132.473 155.670 120.451 1.00 37.37  ? 106 ASP B N   1 
ATOM   5213 C CA  . ASP D 4 37  ? 133.016 154.368 120.067 1.00 37.37  ? 106 ASP B CA  1 
ATOM   5214 C C   . ASP D 4 37  ? 131.970 153.314 120.391 1.00 37.37  ? 106 ASP B C   1 
ATOM   5215 O O   . ASP D 4 37  ? 131.711 153.037 121.560 1.00 37.37  ? 106 ASP B O   1 
ATOM   5216 C CB  . ASP D 4 37  ? 134.297 154.062 120.808 1.00 37.37  ? 106 ASP B CB  1 
ATOM   5217 C CG  . ASP D 4 37  ? 135.420 154.941 120.397 1.00 37.37  ? 106 ASP B CG  1 
ATOM   5218 O OD1 . ASP D 4 37  ? 135.397 155.415 119.250 1.00 37.37  ? 106 ASP B OD1 1 
ATOM   5219 O OD2 . ASP D 4 37  ? 136.335 155.154 121.213 1.00 37.37  ? 106 ASP B OD2 1 
ATOM   5220 N N   . LEU D 4 38  ? 131.377 152.720 119.371 1.00 35.52  ? 107 LEU B N   1 
ATOM   5221 C CA  . LEU D 4 38  ? 130.370 151.688 119.547 1.00 35.52  ? 107 LEU B CA  1 
ATOM   5222 C C   . LEU D 4 38  ? 130.934 150.346 119.104 1.00 35.52  ? 107 LEU B C   1 
ATOM   5223 O O   . LEU D 4 38  ? 131.256 150.165 117.930 1.00 35.52  ? 107 LEU B O   1 
ATOM   5224 C CB  . LEU D 4 38  ? 129.114 152.036 118.762 1.00 35.52  ? 107 LEU B CB  1 
ATOM   5225 C CG  . LEU D 4 38  ? 127.986 151.027 118.721 1.00 35.52  ? 107 LEU B CG  1 
ATOM   5226 C CD1 . LEU D 4 38  ? 127.519 150.655 120.090 1.00 35.52  ? 107 LEU B CD1 1 
ATOM   5227 C CD2 . LEU D 4 38  ? 126.870 151.658 117.946 1.00 35.52  ? 107 LEU B CD2 1 
ATOM   5228 N N   . TYR D 4 39  ? 131.038 149.407 120.039 1.00 34.78  ? 108 TYR B N   1 
ATOM   5229 C CA  . TYR D 4 39  ? 131.547 148.071 119.773 1.00 34.78  ? 108 TYR B CA  1 
ATOM   5230 C C   . TYR D 4 39  ? 130.395 147.089 119.890 1.00 34.78  ? 108 TYR B C   1 
ATOM   5231 O O   . TYR D 4 39  ? 129.796 146.969 120.957 1.00 34.78  ? 108 TYR B O   1 
ATOM   5232 C CB  . TYR D 4 39  ? 132.652 147.715 120.760 1.00 34.78  ? 108 TYR B CB  1 
ATOM   5233 C CG  . TYR D 4 39  ? 133.356 146.406 120.501 1.00 34.78  ? 108 TYR B CG  1 
ATOM   5234 C CD1 . TYR D 4 39  ? 134.353 146.314 119.555 1.00 34.78  ? 108 TYR B CD1 1 
ATOM   5235 C CD2 . TYR D 4 39  ? 133.024 145.266 121.206 1.00 34.78  ? 108 TYR B CD2 1 
ATOM   5236 C CE1 . TYR D 4 39  ? 134.998 145.129 119.319 1.00 34.78  ? 108 TYR B CE1 1 
ATOM   5237 C CE2 . TYR D 4 39  ? 133.660 144.077 120.969 1.00 34.78  ? 108 TYR B CE2 1 
ATOM   5238 C CZ  . TYR D 4 39  ? 134.643 144.017 120.027 1.00 34.78  ? 108 TYR B CZ  1 
ATOM   5239 O OH  . TYR D 4 39  ? 135.285 142.832 119.797 1.00 34.78  ? 108 TYR B OH  1 
ATOM   5240 N N   . TYR D 4 40  ? 130.077 146.397 118.806 1.00 35.35  ? 109 TYR B N   1 
ATOM   5241 C CA  . TYR D 4 40  ? 129.068 145.354 118.870 1.00 35.35  ? 109 TYR B CA  1 
ATOM   5242 C C   . TYR D 4 40  ? 129.699 144.063 119.361 1.00 35.35  ? 109 TYR B C   1 
ATOM   5243 O O   . TYR D 4 40  ? 130.826 143.732 118.986 1.00 35.35  ? 109 TYR B O   1 
ATOM   5244 C CB  . TYR D 4 40  ? 128.381 145.094 117.530 1.00 35.35  ? 109 TYR B CB  1 
ATOM   5245 C CG  . TYR D 4 40  ? 127.347 146.111 117.106 1.00 35.35  ? 109 TYR B CG  1 
ATOM   5246 C CD1 . TYR D 4 40  ? 127.138 147.267 117.820 1.00 35.35  ? 109 TYR B CD1 1 
ATOM   5247 C CD2 . TYR D 4 40  ? 126.495 145.847 116.060 1.00 35.35  ? 109 TYR B CD2 1 
ATOM   5248 C CE1 . TYR D 4 40  ? 126.186 148.166 117.435 1.00 35.35  ? 109 TYR B CE1 1 
ATOM   5249 C CE2 . TYR D 4 40  ? 125.535 146.742 115.688 1.00 35.35  ? 109 TYR B CE2 1 
ATOM   5250 C CZ  . TYR D 4 40  ? 125.381 147.888 116.379 1.00 35.35  ? 109 TYR B CZ  1 
ATOM   5251 O OH  . TYR D 4 40  ? 124.414 148.778 116.002 1.00 35.35  ? 109 TYR B OH  1 
ATOM   5252 N N   . LEU D 4 41  ? 128.961 143.336 120.192 1.00 34.94  ? 110 LEU B N   1 
ATOM   5253 C CA  . LEU D 4 41  ? 129.365 142.032 120.703 1.00 34.94  ? 110 LEU B CA  1 
ATOM   5254 C C   . LEU D 4 41  ? 128.180 141.101 120.481 1.00 34.94  ? 110 LEU B C   1 
ATOM   5255 O O   . LEU D 4 41  ? 127.225 141.114 121.257 1.00 34.94  ? 110 LEU B O   1 
ATOM   5256 C CB  . LEU D 4 41  ? 129.751 142.127 122.168 1.00 34.94  ? 110 LEU B CB  1 
ATOM   5257 C CG  . LEU D 4 41  ? 130.278 140.883 122.863 1.00 34.94  ? 110 LEU B CG  1 
ATOM   5258 C CD1 . LEU D 4 41  ? 131.543 140.438 122.204 1.00 34.94  ? 110 LEU B CD1 1 
ATOM   5259 C CD2 . LEU D 4 41  ? 130.507 141.170 124.326 1.00 34.94  ? 110 LEU B CD2 1 
ATOM   5260 N N   . VAL D 4 42  ? 128.232 140.299 119.434 1.00 35.11  ? 111 VAL B N   1 
ATOM   5261 C CA  . VAL D 4 42  ? 127.058 139.600 118.935 1.00 35.11  ? 111 VAL B CA  1 
ATOM   5262 C C   . VAL D 4 42  ? 127.106 138.143 119.366 1.00 35.11  ? 111 VAL B C   1 
ATOM   5263 O O   . VAL D 4 42  ? 128.148 137.491 119.289 1.00 35.11  ? 111 VAL B O   1 
ATOM   5264 C CB  . VAL D 4 42  ? 126.963 139.735 117.403 1.00 35.11  ? 111 VAL B CB  1 
ATOM   5265 C CG1 . VAL D 4 42  ? 125.730 139.049 116.853 1.00 35.11  ? 111 VAL B CG1 1 
ATOM   5266 C CG2 . VAL D 4 42  ? 126.952 141.191 117.017 1.00 35.11  ? 111 VAL B CG2 1 
ATOM   5267 N N   . ASP D 4 43  ? 125.980 137.647 119.857 1.00 37.34  ? 112 ASP B N   1 
ATOM   5268 C CA  . ASP D 4 43  ? 125.779 136.222 120.037 1.00 37.34  ? 112 ASP B CA  1 
ATOM   5269 C C   . ASP D 4 43  ? 125.746 135.540 118.675 1.00 37.34  ? 112 ASP B C   1 
ATOM   5270 O O   . ASP D 4 43  ? 124.973 135.921 117.794 1.00 37.34  ? 112 ASP B O   1 
ATOM   5271 C CB  . ASP D 4 43  ? 124.472 135.999 120.781 1.00 37.34  ? 112 ASP B CB  1 
ATOM   5272 C CG  . ASP D 4 43  ? 124.340 134.621 121.342 1.00 37.34  ? 112 ASP B CG  1 
ATOM   5273 O OD1 . ASP D 4 43  ? 125.274 133.812 121.198 1.00 37.34  ? 112 ASP B OD1 1 
ATOM   5274 O OD2 . ASP D 4 43  ? 123.284 134.345 121.941 1.00 37.34  ? 112 ASP B OD2 1 
ATOM   5275 N N   . VAL D 4 44  ? 126.577 134.513 118.510 1.00 37.88  ? 113 VAL B N   1 
ATOM   5276 C CA  . VAL D 4 44  ? 126.826 133.881 117.222 1.00 37.88  ? 113 VAL B CA  1 
ATOM   5277 C C   . VAL D 4 44  ? 125.968 132.627 117.059 1.00 37.88  ? 113 VAL B C   1 
ATOM   5278 O O   . VAL D 4 44  ? 126.223 131.794 116.192 1.00 37.88  ? 113 VAL B O   1 
ATOM   5279 C CB  . VAL D 4 44  ? 128.339 133.606 117.099 1.00 37.88  ? 113 VAL B CB  1 
ATOM   5280 C CG1 . VAL D 4 44  ? 128.843 133.357 115.695 1.00 37.88  ? 113 VAL B CG1 1 
ATOM   5281 C CG2 . VAL D 4 44  ? 129.069 134.771 117.596 1.00 37.88  ? 113 VAL B CG2 1 
ATOM   5282 N N   . SER D 4 45  ? 124.925 132.491 117.866 1.00 39.26  ? 114 SER B N   1 
ATOM   5283 C CA  . SER D 4 45  ? 124.090 131.309 117.812 1.00 39.26  ? 114 SER B CA  1 
ATOM   5284 C C   . SER D 4 45  ? 123.264 131.285 116.530 1.00 39.26  ? 114 SER B C   1 
ATOM   5285 O O   . SER D 4 45  ? 123.215 132.246 115.766 1.00 39.26  ? 114 SER B O   1 
ATOM   5286 C CB  . SER D 4 45  ? 123.177 131.253 119.027 1.00 39.26  ? 114 SER B CB  1 
ATOM   5287 O OG  . SER D 4 45  ? 123.933 131.105 120.210 1.00 39.26  ? 114 SER B OG  1 
ATOM   5288 N N   . ALA D 4 46  ? 122.614 130.152 116.297 1.00 41.23  ? 115 ALA B N   1 
ATOM   5289 C CA  . ALA D 4 46  ? 121.879 129.983 115.054 1.00 41.23  ? 115 ALA B CA  1 
ATOM   5290 C C   . ALA D 4 46  ? 120.553 130.717 115.090 1.00 41.23  ? 115 ALA B C   1 
ATOM   5291 O O   . ALA D 4 46  ? 119.957 130.982 114.042 1.00 41.23  ? 115 ALA B O   1 
ATOM   5292 C CB  . ALA D 4 46  ? 121.663 128.505 114.775 1.00 41.23  ? 115 ALA B CB  1 
ATOM   5293 N N   . SER D 4 47  ? 120.071 131.045 116.286 1.00 41.15  ? 116 SER B N   1 
ATOM   5294 C CA  . SER D 4 47  ? 118.830 131.794 116.406 1.00 41.15  ? 116 SER B CA  1 
ATOM   5295 C C   . SER D 4 47  ? 119.019 133.260 116.070 1.00 41.15  ? 116 SER B C   1 
ATOM   5296 O O   . SER D 4 47  ? 118.036 133.962 115.817 1.00 41.15  ? 116 SER B O   1 
ATOM   5297 C CB  . SER D 4 47  ? 118.286 131.652 117.820 1.00 41.15  ? 116 SER B CB  1 
ATOM   5298 O OG  . SER D 4 47  ? 119.175 132.242 118.746 1.00 41.15  ? 116 SER B OG  1 
ATOM   5299 N N   . MET D 4 48  ? 120.258 133.728 116.052 1.00 40.83  ? 117 MET B N   1 
ATOM   5300 C CA  . MET D 4 48  ? 120.592 135.131 115.894 1.00 40.83  ? 117 MET B CA  1 
ATOM   5301 C C   . MET D 4 48  ? 120.817 135.542 114.451 1.00 40.83  ? 117 MET B C   1 
ATOM   5302 O O   . MET D 4 48  ? 121.350 136.627 114.221 1.00 40.83  ? 117 MET B O   1 
ATOM   5303 C CB  . MET D 4 48  ? 121.847 135.429 116.703 1.00 40.83  ? 117 MET B CB  1 
ATOM   5304 C CG  . MET D 4 48  ? 121.651 135.339 118.188 1.00 40.83  ? 117 MET B CG  1 
ATOM   5305 S SD  . MET D 4 48  ? 120.586 136.645 118.785 1.00 40.83  ? 117 MET B SD  1 
ATOM   5306 C CE  . MET D 4 48  ? 121.673 138.036 118.541 1.00 40.83  ? 117 MET B CE  1 
ATOM   5307 N N   . HIS D 4 49  ? 120.433 134.722 113.475 1.00 44.08  ? 118 HIS B N   1 
ATOM   5308 C CA  . HIS D 4 49  ? 120.879 134.970 112.111 1.00 44.08  ? 118 HIS B CA  1 
ATOM   5309 C C   . HIS D 4 49  ? 120.049 136.047 111.433 1.00 44.08  ? 118 HIS B C   1 
ATOM   5310 O O   . HIS D 4 49  ? 120.529 136.714 110.512 1.00 44.08  ? 118 HIS B O   1 
ATOM   5311 C CB  . HIS D 4 49  ? 120.846 133.681 111.299 1.00 44.08  ? 118 HIS B CB  1 
ATOM   5312 C CG  . HIS D 4 49  ? 119.470 133.158 111.050 1.00 44.08  ? 118 HIS B CG  1 
ATOM   5313 N ND1 . HIS D 4 49  ? 118.765 132.439 111.990 1.00 44.08  ? 118 HIS B ND1 1 
ATOM   5314 C CD2 . HIS D 4 49  ? 118.669 133.243 109.963 1.00 44.08  ? 118 HIS B CD2 1 
ATOM   5315 C CE1 . HIS D 4 49  ? 117.587 132.109 111.495 1.00 44.08  ? 118 HIS B CE1 1 
ATOM   5316 N NE2 . HIS D 4 49  ? 117.504 132.584 110.265 1.00 44.08  ? 118 HIS B NE2 1 
ATOM   5317 N N   . ASN D 4 50  ? 118.802 136.234 111.862 1.00 42.60  ? 119 ASN B N   1 
ATOM   5318 C CA  . ASN D 4 50  ? 118.026 137.363 111.365 1.00 42.60  ? 119 ASN B CA  1 
ATOM   5319 C C   . ASN D 4 50  ? 118.537 138.661 111.960 1.00 42.60  ? 119 ASN B C   1 
ATOM   5320 O O   . ASN D 4 50  ? 118.337 139.742 111.404 1.00 42.60  ? 119 ASN B O   1 
ATOM   5321 C CB  . ASN D 4 50  ? 116.547 137.175 111.682 1.00 42.60  ? 119 ASN B CB  1 
ATOM   5322 C CG  . ASN D 4 50  ? 115.883 136.176 110.778 1.00 42.60  ? 119 ASN B CG  1 
ATOM   5323 O OD1 . ASN D 4 50  ? 116.136 136.150 109.581 1.00 42.60  ? 119 ASN B OD1 1 
ATOM   5324 N ND2 . ASN D 4 50  ? 115.013 135.356 111.340 1.00 42.60  ? 119 ASN B ND2 1 
ATOM   5325 N N   . ASN D 4 51  ? 119.205 138.566 113.101 1.00 41.83  ? 120 ASN B N   1 
ATOM   5326 C CA  . ASN D 4 51  ? 119.727 139.751 113.755 1.00 41.83  ? 120 ASN B CA  1 
ATOM   5327 C C   . ASN D 4 51  ? 121.050 140.179 113.141 1.00 41.83  ? 120 ASN B C   1 
ATOM   5328 O O   . ASN D 4 51  ? 121.376 141.369 113.119 1.00 41.83  ? 120 ASN B O   1 
ATOM   5329 C CB  . ASN D 4 51  ? 119.881 139.467 115.241 1.00 41.83  ? 120 ASN B CB  1 
ATOM   5330 C CG  . ASN D 4 51  ? 118.565 139.380 115.943 1.00 41.83  ? 120 ASN B CG  1 
ATOM   5331 O OD1 . ASN D 4 51  ? 117.674 140.184 115.705 1.00 41.83  ? 120 ASN B OD1 1 
ATOM   5332 N ND2 . ASN D 4 51  ? 118.424 138.397 116.809 1.00 41.83  ? 120 ASN B ND2 1 
ATOM   5333 N N   . ILE D 4 52  ? 121.839 139.221 112.663 1.00 42.11  ? 121 ILE B N   1 
ATOM   5334 C CA  . ILE D 4 52  ? 123.084 139.556 111.985 1.00 42.11  ? 121 ILE B CA  1 
ATOM   5335 C C   . ILE D 4 52  ? 122.784 140.006 110.561 1.00 42.11  ? 121 ILE B C   1 
ATOM   5336 O O   . ILE D 4 52  ? 123.547 140.767 109.955 1.00 42.11  ? 121 ILE B O   1 
ATOM   5337 C CB  . ILE D 4 52  ? 124.048 138.356 112.051 1.00 42.11  ? 121 ILE B CB  1 
ATOM   5338 C CG1 . ILE D 4 52  ? 124.259 137.958 113.502 1.00 42.11  ? 121 ILE B CG1 1 
ATOM   5339 C CG2 . ILE D 4 52  ? 125.423 138.695 111.529 1.00 42.11  ? 121 ILE B CG2 1 
ATOM   5340 C CD1 . ILE D 4 52  ? 124.967 136.643 113.675 1.00 42.11  ? 121 ILE B CD1 1 
ATOM   5341 N N   . GLU D 4 53  ? 121.655 139.556 110.016 1.00 44.28  ? 122 GLU B N   1 
ATOM   5342 C CA  . GLU D 4 53  ? 121.115 140.131 108.790 1.00 44.28  ? 122 GLU B CA  1 
ATOM   5343 C C   . GLU D 4 53  ? 120.846 141.619 108.950 1.00 44.28  ? 122 GLU B C   1 
ATOM   5344 O O   . GLU D 4 53  ? 121.186 142.424 108.079 1.00 44.28  ? 122 GLU B O   1 
ATOM   5345 C CB  . GLU D 4 53  ? 119.828 139.409 108.401 1.00 44.28  ? 122 GLU B CB  1 
ATOM   5346 C CG  . GLU D 4 53  ? 119.102 140.057 107.248 1.00 44.28  ? 122 GLU B CG  1 
ATOM   5347 C CD  . GLU D 4 53  ? 117.760 139.428 106.972 1.00 44.28  ? 122 GLU B CD  1 
ATOM   5348 O OE1 . GLU D 4 53  ? 117.450 138.387 107.580 1.00 44.28  ? 122 GLU B OE1 1 
ATOM   5349 O OE2 . GLU D 4 53  ? 116.981 140.024 106.199 1.00 44.28  ? 122 GLU B OE2 1 
ATOM   5350 N N   . LYS D 4 54  ? 120.263 142.008 110.082 1.00 40.69  ? 123 LYS B N   1 
ATOM   5351 C CA  . LYS D 4 54  ? 119.910 143.403 110.281 1.00 40.69  ? 123 LYS B CA  1 
ATOM   5352 C C   . LYS D 4 54  ? 121.084 144.240 110.753 1.00 40.69  ? 123 LYS B C   1 
ATOM   5353 O O   . LYS D 4 54  ? 120.912 145.433 110.997 1.00 40.69  ? 123 LYS B O   1 
ATOM   5354 C CB  . LYS D 4 54  ? 118.758 143.510 111.272 1.00 40.69  ? 123 LYS B CB  1 
ATOM   5355 N N   . LEU D 4 55  ? 122.274 143.656 110.883 1.00 39.89  ? 124 LEU B N   1 
ATOM   5356 C CA  . LEU D 4 55  ? 123.459 144.465 111.131 1.00 39.89  ? 124 LEU B CA  1 
ATOM   5357 C C   . LEU D 4 55  ? 123.995 145.085 109.860 1.00 39.89  ? 124 LEU B C   1 
ATOM   5358 O O   . LEU D 4 55  ? 124.951 145.861 109.913 1.00 39.89  ? 124 LEU B O   1 
ATOM   5359 C CB  . LEU D 4 55  ? 124.567 143.645 111.780 1.00 39.89  ? 124 LEU B CB  1 
ATOM   5360 C CG  . LEU D 4 55  ? 124.283 143.077 113.157 1.00 39.89  ? 124 LEU B CG  1 
ATOM   5361 C CD1 . LEU D 4 55  ? 125.530 142.448 113.716 1.00 39.89  ? 124 LEU B CD1 1 
ATOM   5362 C CD2 . LEU D 4 55  ? 123.779 144.160 114.041 1.00 39.89  ? 124 LEU B CD2 1 
ATOM   5363 N N   . ASN D 4 56  ? 123.420 144.725 108.720 1.00 43.10  ? 125 ASN B N   1 
ATOM   5364 C CA  . ASN D 4 56  ? 123.782 145.345 107.459 1.00 43.10  ? 125 ASN B CA  1 
ATOM   5365 C C   . ASN D 4 56  ? 123.356 146.803 107.429 1.00 43.10  ? 125 ASN B C   1 
ATOM   5366 O O   . ASN D 4 56  ? 124.048 147.642 106.844 1.00 43.10  ? 125 ASN B O   1 
ATOM   5367 C CB  . ASN D 4 56  ? 123.122 144.570 106.325 1.00 43.10  ? 125 ASN B CB  1 
ATOM   5368 C CG  . ASN D 4 56  ? 123.587 143.137 106.257 1.00 43.10  ? 125 ASN B CG  1 
ATOM   5369 O OD1 . ASN D 4 56  ? 124.765 142.848 106.412 1.00 43.10  ? 125 ASN B OD1 1 
ATOM   5370 N ND2 . ASN D 4 56  ? 122.653 142.228 106.046 1.00 43.10  ? 125 ASN B ND2 1 
ATOM   5371 N N   . SER D 4 57  ? 122.244 147.125 108.097 1.00 43.52  ? 126 SER B N   1 
ATOM   5372 C CA  . SER D 4 57  ? 121.671 148.463 108.082 1.00 43.52  ? 126 SER B CA  1 
ATOM   5373 C C   . SER D 4 57  ? 122.329 149.408 109.069 1.00 43.52  ? 126 SER B C   1 
ATOM   5374 O O   . SER D 4 57  ? 121.798 150.492 109.308 1.00 43.52  ? 126 SER B O   1 
ATOM   5375 C CB  . SER D 4 57  ? 120.188 148.381 108.395 1.00 43.52  ? 126 SER B CB  1 
ATOM   5376 O OG  . SER D 4 57  ? 119.527 147.583 107.436 1.00 43.52  ? 126 SER B OG  1 
ATOM   5377 N N   . VAL D 4 58  ? 123.453 149.024 109.666 1.00 43.27  ? 127 VAL B N   1 
ATOM   5378 C CA  . VAL D 4 58  ? 124.119 149.894 110.627 1.00 43.27  ? 127 VAL B CA  1 
ATOM   5379 C C   . VAL D 4 58  ? 124.839 151.031 109.913 1.00 43.27  ? 127 VAL B C   1 
ATOM   5380 O O   . VAL D 4 58  ? 124.740 152.195 110.314 1.00 43.27  ? 127 VAL B O   1 
ATOM   5381 C CB  . VAL D 4 58  ? 125.076 149.067 111.505 1.00 43.27  ? 127 VAL B CB  1 
ATOM   5382 C CG1 . VAL D 4 58  ? 125.914 149.961 112.394 1.00 43.27  ? 127 VAL B CG1 1 
ATOM   5383 C CG2 . VAL D 4 58  ? 124.288 148.091 112.345 1.00 43.27  ? 127 VAL B CG2 1 
ATOM   5384 N N   . GLY D 4 59  ? 125.561 150.718 108.839 1.00 44.60  ? 128 GLY B N   1 
ATOM   5385 C CA  . GLY D 4 59  ? 126.339 151.738 108.161 1.00 44.60  ? 128 GLY B CA  1 
ATOM   5386 C C   . GLY D 4 59  ? 125.497 152.734 107.394 1.00 44.60  ? 128 GLY B C   1 
ATOM   5387 O O   . GLY D 4 59  ? 125.944 153.851 107.121 1.00 44.60  ? 128 GLY B O   1 
ATOM   5388 N N   . ASN D 4 60  ? 124.275 152.356 107.039 1.00 44.73  ? 129 ASN B N   1 
ATOM   5389 C CA  . ASN D 4 60  ? 123.390 153.257 106.318 1.00 44.73  ? 129 ASN B CA  1 
ATOM   5390 C C   . ASN D 4 60  ? 122.489 154.031 107.271 1.00 44.73  ? 129 ASN B C   1 
ATOM   5391 O O   . ASN D 4 60  ? 122.572 155.258 107.354 1.00 44.73  ? 129 ASN B O   1 
ATOM   5392 C CB  . ASN D 4 60  ? 122.551 152.465 105.311 1.00 44.73  ? 129 ASN B CB  1 
ATOM   5393 N N   . ASP D 4 61  ? 121.645 153.324 108.016 1.00 43.66  ? 130 ASP B N   1 
ATOM   5394 C CA  . ASP D 4 61  ? 120.581 153.990 108.754 1.00 43.66  ? 130 ASP B CA  1 
ATOM   5395 C C   . ASP D 4 61  ? 121.049 154.510 110.107 1.00 43.66  ? 130 ASP B C   1 
ATOM   5396 O O   . ASP D 4 61  ? 120.592 155.566 110.548 1.00 43.66  ? 130 ASP B O   1 
ATOM   5397 C CB  . ASP D 4 61  ? 119.398 153.042 108.930 1.00 43.66  ? 130 ASP B CB  1 
ATOM   5398 N N   . LEU D 4 62  ? 121.942 153.793 110.786 1.00 43.07  ? 131 LEU B N   1 
ATOM   5399 C CA  . LEU D 4 62  ? 122.330 154.204 112.131 1.00 43.07  ? 131 LEU B CA  1 
ATOM   5400 C C   . LEU D 4 62  ? 123.346 155.332 112.098 1.00 43.07  ? 131 LEU B C   1 
ATOM   5401 O O   . LEU D 4 62  ? 123.289 156.250 112.921 1.00 43.07  ? 131 LEU B O   1 
ATOM   5402 C CB  . LEU D 4 62  ? 122.880 153.016 112.914 1.00 43.07  ? 131 LEU B CB  1 
ATOM   5403 C CG  . LEU D 4 62  ? 123.398 153.287 114.327 1.00 43.07  ? 131 LEU B CG  1 
ATOM   5404 C CD1 . LEU D 4 62  ? 122.302 153.835 115.196 1.00 43.07  ? 131 LEU B CD1 1 
ATOM   5405 C CD2 . LEU D 4 62  ? 123.965 152.034 114.931 1.00 43.07  ? 131 LEU B CD2 1 
ATOM   5406 N N   . SER D 4 63  ? 124.290 155.283 111.160 1.00 42.52  ? 132 SER B N   1 
ATOM   5407 C CA  . SER D 4 63  ? 125.367 156.265 111.171 1.00 42.52  ? 132 SER B CA  1 
ATOM   5408 C C   . SER D 4 63  ? 124.879 157.619 110.689 1.00 42.52  ? 132 SER B C   1 
ATOM   5409 O O   . SER D 4 63  ? 125.484 158.650 110.995 1.00 42.52  ? 132 SER B O   1 
ATOM   5410 C CB  . SER D 4 63  ? 126.532 155.782 110.316 1.00 42.52  ? 132 SER B CB  1 
ATOM   5411 O OG  . SER D 4 63  ? 127.594 156.718 110.338 1.00 42.52  ? 132 SER B OG  1 
ATOM   5412 N N   . ARG D 4 64  ? 123.788 157.636 109.927 1.00 43.34  ? 133 ARG B N   1 
ATOM   5413 C CA  . ARG D 4 64  ? 123.180 158.899 109.538 1.00 43.34  ? 133 ARG B CA  1 
ATOM   5414 C C   . ARG D 4 64  ? 122.467 159.535 110.717 1.00 43.34  ? 133 ARG B C   1 
ATOM   5415 O O   . ARG D 4 64  ? 122.472 160.759 110.877 1.00 43.34  ? 133 ARG B O   1 
ATOM   5416 C CB  . ARG D 4 64  ? 122.207 158.674 108.384 1.00 43.34  ? 133 ARG B CB  1 
ATOM   5417 N N   . LYS D 4 65  ? 121.840 158.708 111.555 1.00 41.50  ? 134 LYS B N   1 
ATOM   5418 C CA  . LYS D 4 65  ? 121.135 159.218 112.723 1.00 41.50  ? 134 LYS B CA  1 
ATOM   5419 C C   . LYS D 4 65  ? 122.103 159.697 113.785 1.00 41.50  ? 134 LYS B C   1 
ATOM   5420 O O   . LYS D 4 65  ? 121.851 160.696 114.460 1.00 41.50  ? 134 LYS B O   1 
ATOM   5421 C CB  . LYS D 4 65  ? 120.233 158.137 113.298 1.00 41.50  ? 134 LYS B CB  1 
ATOM   5422 C CG  . LYS D 4 65  ? 119.066 157.765 112.442 1.00 41.50  ? 134 LYS B CG  1 
ATOM   5423 C CD  . LYS D 4 65  ? 118.286 156.662 113.108 1.00 41.50  ? 134 LYS B CD  1 
ATOM   5424 C CE  . LYS D 4 65  ? 117.017 156.359 112.352 1.00 41.50  ? 134 LYS B CE  1 
ATOM   5425 N NZ  . LYS D 4 65  ? 117.300 155.785 111.015 1.00 41.50  ? 134 LYS B NZ  1 
ATOM   5426 N N   . MET D 4 66  ? 123.214 159.002 113.951 1.00 41.98  ? 135 MET B N   1 
ATOM   5427 C CA  . MET D 4 66  ? 124.137 159.347 115.016 1.00 41.98  ? 135 MET B CA  1 
ATOM   5428 C C   . MET D 4 66  ? 125.014 160.531 114.682 1.00 41.98  ? 135 MET B C   1 
ATOM   5429 O O   . MET D 4 66  ? 125.779 160.961 115.547 1.00 41.98  ? 135 MET B O   1 
ATOM   5430 C CB  . MET D 4 66  ? 125.005 158.141 115.359 1.00 41.98  ? 135 MET B CB  1 
ATOM   5431 C CG  . MET D 4 66  ? 124.272 157.031 116.074 1.00 41.98  ? 135 MET B CG  1 
ATOM   5432 S SD  . MET D 4 66  ? 123.730 157.516 117.711 1.00 41.98  ? 135 MET B SD  1 
ATOM   5433 C CE  . MET D 4 66  ? 125.310 157.661 118.515 1.00 41.98  ? 135 MET B CE  1 
ATOM   5434 N N   . ALA D 4 67  ? 124.951 161.059 113.463 1.00 41.83  ? 136 ALA B N   1 
ATOM   5435 C CA  . ALA D 4 67  ? 125.688 162.278 113.163 1.00 41.83  ? 136 ALA B CA  1 
ATOM   5436 C C   . ALA D 4 67  ? 125.029 163.486 113.802 1.00 41.83  ? 136 ALA B C   1 
ATOM   5437 O O   . ALA D 4 67  ? 125.703 164.472 114.111 1.00 41.83  ? 136 ALA B O   1 
ATOM   5438 C CB  . ALA D 4 67  ? 125.801 162.468 111.655 1.00 41.83  ? 136 ALA B CB  1 
ATOM   5439 N N   . PHE D 4 68  ? 123.722 163.418 114.024 1.00 42.62  ? 137 PHE B N   1 
ATOM   5440 C CA  . PHE D 4 68  ? 122.983 164.485 114.672 1.00 42.62  ? 137 PHE B CA  1 
ATOM   5441 C C   . PHE D 4 68  ? 123.157 164.494 116.182 1.00 42.62  ? 137 PHE B C   1 
ATOM   5442 O O   . PHE D 4 68  ? 122.613 165.383 116.842 1.00 42.62  ? 137 PHE B O   1 
ATOM   5443 C CB  . PHE D 4 68  ? 121.499 164.366 114.331 1.00 42.62  ? 137 PHE B CB  1 
ATOM   5444 N N   . PHE D 4 69  ? 123.882 163.532 116.745 1.00 42.54  ? 138 PHE B N   1 
ATOM   5445 C CA  . PHE D 4 69  ? 124.103 163.466 118.178 1.00 42.54  ? 138 PHE B CA  1 
ATOM   5446 C C   . PHE D 4 69  ? 125.558 163.391 118.574 1.00 42.54  ? 138 PHE B C   1 
ATOM   5447 O O   . PHE D 4 69  ? 125.864 163.635 119.742 1.00 42.54  ? 138 PHE B O   1 
ATOM   5448 C CB  . PHE D 4 69  ? 123.402 162.244 118.776 1.00 42.54  ? 138 PHE B CB  1 
ATOM   5449 C CG  . PHE D 4 69  ? 121.928 162.242 118.589 1.00 42.54  ? 138 PHE B CG  1 
ATOM   5450 C CD1 . PHE D 4 69  ? 121.118 163.039 119.366 1.00 42.54  ? 138 PHE B CD1 1 
ATOM   5451 C CD2 . PHE D 4 69  ? 121.349 161.414 117.654 1.00 42.54  ? 138 PHE B CD2 1 
ATOM   5452 C CE1 . PHE D 4 69  ? 119.755 163.028 119.194 1.00 42.54  ? 138 PHE B CE1 1 
ATOM   5453 C CE2 . PHE D 4 69  ? 119.988 161.396 117.478 1.00 42.54  ? 138 PHE B CE2 1 
ATOM   5454 C CZ  . PHE D 4 69  ? 119.191 162.204 118.247 1.00 42.54  ? 138 PHE B CZ  1 
ATOM   5455 N N   . SER D 4 70  ? 126.458 163.045 117.670 1.00 42.21  ? 139 SER B N   1 
ATOM   5456 C CA  . SER D 4 70  ? 127.846 162.810 118.008 1.00 42.21  ? 139 SER B CA  1 
ATOM   5457 C C   . SER D 4 70  ? 128.740 163.516 117.011 1.00 42.21  ? 139 SER B C   1 
ATOM   5458 O O   . SER D 4 70  ? 128.311 163.888 115.919 1.00 42.21  ? 139 SER B O   1 
ATOM   5459 C CB  . SER D 4 70  ? 128.158 161.321 118.003 1.00 42.21  ? 139 SER B CB  1 
ATOM   5460 O OG  . SER D 4 70  ? 128.011 160.801 116.698 1.00 42.21  ? 139 SER B OG  1 
ATOM   5461 N N   . ARG D 4 71  ? 130.003 163.690 117.377 1.00 45.04  ? 140 ARG B N   1 
ATOM   5462 C CA  . ARG D 4 71  ? 130.953 164.269 116.447 1.00 45.04  ? 140 ARG B CA  1 
ATOM   5463 C C   . ARG D 4 71  ? 131.835 163.240 115.758 1.00 45.04  ? 140 ARG B C   1 
ATOM   5464 O O   . ARG D 4 71  ? 132.341 163.522 114.669 1.00 45.04  ? 140 ARG B O   1 
ATOM   5465 C CB  . ARG D 4 71  ? 131.834 165.308 117.148 1.00 45.04  ? 140 ARG B CB  1 
ATOM   5466 C CG  . ARG D 4 71  ? 132.679 164.776 118.250 1.00 45.04  ? 140 ARG B CG  1 
ATOM   5467 C CD  . ARG D 4 71  ? 133.534 165.868 118.823 1.00 45.04  ? 140 ARG B CD  1 
ATOM   5468 N NE  . ARG D 4 71  ? 134.537 166.318 117.867 1.00 45.04  ? 140 ARG B NE  1 
ATOM   5469 C CZ  . ARG D 4 71  ? 135.260 167.424 118.008 1.00 45.04  ? 140 ARG B CZ  1 
ATOM   5470 N NH1 . ARG D 4 71  ? 135.094 168.198 119.072 1.00 45.04  ? 140 ARG B NH1 1 
ATOM   5471 N NH2 . ARG D 4 71  ? 136.153 167.757 117.087 1.00 45.04  ? 140 ARG B NH2 1 
ATOM   5472 N N   . ASP D 4 72  ? 132.016 162.063 116.350 1.00 44.14  ? 141 ASP B N   1 
ATOM   5473 C CA  . ASP D 4 72  ? 132.707 160.944 115.731 1.00 44.14  ? 141 ASP B CA  1 
ATOM   5474 C C   . ASP D 4 72  ? 131.848 159.704 115.895 1.00 44.14  ? 141 ASP B C   1 
ATOM   5475 O O   . ASP D 4 72  ? 130.931 159.677 116.716 1.00 44.14  ? 141 ASP B O   1 
ATOM   5476 C CB  . ASP D 4 72  ? 134.066 160.702 116.362 1.00 44.14  ? 141 ASP B CB  1 
ATOM   5477 C CG  . ASP D 4 72  ? 135.048 161.801 116.058 1.00 44.14  ? 141 ASP B CG  1 
ATOM   5478 O OD1 . ASP D 4 72  ? 134.964 162.383 114.960 1.00 44.14  ? 141 ASP B OD1 1 
ATOM   5479 O OD2 . ASP D 4 72  ? 135.902 162.093 116.922 1.00 44.14  ? 141 ASP B OD2 1 
ATOM   5480 N N   . PHE D 4 73  ? 132.146 158.676 115.114 1.00 39.32  ? 142 PHE B N   1 
ATOM   5481 C CA  . PHE D 4 73  ? 131.399 157.429 115.192 1.00 39.32  ? 142 PHE B CA  1 
ATOM   5482 C C   . PHE D 4 73  ? 132.289 156.325 114.651 1.00 39.32  ? 142 PHE B C   1 
ATOM   5483 O O   . PHE D 4 73  ? 132.439 156.193 113.435 1.00 39.32  ? 142 PHE B O   1 
ATOM   5484 C CB  . PHE D 4 73  ? 130.104 157.531 114.400 1.00 39.32  ? 142 PHE B CB  1 
ATOM   5485 C CG  . PHE D 4 73  ? 129.153 156.420 114.646 1.00 39.32  ? 142 PHE B CG  1 
ATOM   5486 C CD1 . PHE D 4 73  ? 128.463 156.346 115.831 1.00 39.32  ? 142 PHE B CD1 1 
ATOM   5487 C CD2 . PHE D 4 73  ? 128.911 155.476 113.681 1.00 39.32  ? 142 PHE B CD2 1 
ATOM   5488 C CE1 . PHE D 4 73  ? 127.569 155.338 116.058 1.00 39.32  ? 142 PHE B CE1 1 
ATOM   5489 C CE2 . PHE D 4 73  ? 128.012 154.467 113.905 1.00 39.32  ? 142 PHE B CE2 1 
ATOM   5490 C CZ  . PHE D 4 73  ? 127.343 154.401 115.096 1.00 39.32  ? 142 PHE B CZ  1 
ATOM   5491 N N   . ARG D 4 74  ? 132.879 155.539 115.544 1.00 37.78  ? 143 ARG B N   1 
ATOM   5492 C CA  . ARG D 4 74  ? 133.747 154.439 115.166 1.00 37.78  ? 143 ARG B CA  1 
ATOM   5493 C C   . ARG D 4 74  ? 133.122 153.132 115.620 1.00 37.78  ? 143 ARG B C   1 
ATOM   5494 O O   . ARG D 4 74  ? 132.593 153.047 116.727 1.00 37.78  ? 143 ARG B O   1 
ATOM   5495 C CB  . ARG D 4 74  ? 135.128 154.637 115.759 1.00 37.78  ? 143 ARG B CB  1 
ATOM   5496 C CG  . ARG D 4 74  ? 135.786 155.841 115.154 1.00 37.78  ? 143 ARG B CG  1 
ATOM   5497 C CD  . ARG D 4 74  ? 137.085 156.229 115.794 1.00 37.78  ? 143 ARG B CD  1 
ATOM   5498 N NE  . ARG D 4 74  ? 138.178 155.313 115.538 1.00 37.78  ? 143 ARG B NE  1 
ATOM   5499 C CZ  . ARG D 4 74  ? 138.774 154.593 116.476 1.00 37.78  ? 143 ARG B CZ  1 
ATOM   5500 N NH1 . ARG D 4 74  ? 138.376 154.680 117.733 1.00 37.78  ? 143 ARG B NH1 1 
ATOM   5501 N NH2 . ARG D 4 74  ? 139.773 153.785 116.157 1.00 37.78  ? 143 ARG B NH2 1 
ATOM   5502 N N   . LEU D 4 75  ? 133.160 152.123 114.747 1.00 35.84  ? 144 LEU B N   1 
ATOM   5503 C CA  . LEU D 4 75  ? 132.484 150.848 114.955 1.00 35.84  ? 144 LEU B CA  1 
ATOM   5504 C C   . LEU D 4 75  ? 133.479 149.712 115.127 1.00 35.84  ? 144 LEU B C   1 
ATOM   5505 O O   . LEU D 4 75  ? 134.497 149.655 114.436 1.00 35.84  ? 144 LEU B O   1 
ATOM   5506 C CB  . LEU D 4 75  ? 131.562 150.512 113.797 1.00 35.84  ? 144 LEU B CB  1 
ATOM   5507 C CG  . LEU D 4 75  ? 130.342 151.394 113.665 1.00 35.84  ? 144 LEU B CG  1 
ATOM   5508 C CD1 . LEU D 4 75  ? 129.603 151.067 112.409 1.00 35.84  ? 144 LEU B CD1 1 
ATOM   5509 C CD2 . LEU D 4 75  ? 129.471 151.163 114.837 1.00 35.84  ? 144 LEU B CD2 1 
ATOM   5510 N N   . GLY D 4 76  ? 133.163 148.802 116.046 1.00 34.50  ? 145 GLY B N   1 
ATOM   5511 C CA  . GLY D 4 76  ? 133.907 147.581 116.238 1.00 34.50  ? 145 GLY B CA  1 
ATOM   5512 C C   . GLY D 4 76  ? 132.974 146.386 116.189 1.00 34.50  ? 145 GLY B C   1 
ATOM   5513 O O   . GLY D 4 76  ? 131.762 146.524 116.029 1.00 34.50  ? 145 GLY B O   1 
ATOM   5514 N N   . PHE D 4 77  ? 133.563 145.202 116.325 1.00 34.47  ? 146 PHE B N   1 
ATOM   5515 C CA  . PHE D 4 77  ? 132.776 143.985 116.188 1.00 34.47  ? 146 PHE B CA  1 
ATOM   5516 C C   . PHE D 4 77  ? 133.442 142.856 116.957 1.00 34.47  ? 146 PHE B C   1 
ATOM   5517 O O   . PHE D 4 77  ? 134.666 142.731 116.945 1.00 34.47  ? 146 PHE B O   1 
ATOM   5518 C CB  . PHE D 4 77  ? 132.621 143.609 114.718 1.00 34.47  ? 146 PHE B CB  1 
ATOM   5519 C CG  . PHE D 4 77  ? 131.629 142.539 114.478 1.00 34.47  ? 146 PHE B CG  1 
ATOM   5520 C CD1 . PHE D 4 77  ? 130.288 142.816 114.530 1.00 34.47  ? 146 PHE B CD1 1 
ATOM   5521 C CD2 . PHE D 4 77  ? 132.027 141.262 114.196 1.00 34.47  ? 146 PHE B CD2 1 
ATOM   5522 C CE1 . PHE D 4 77  ? 129.362 141.833 114.312 1.00 34.47  ? 146 PHE B CE1 1 
ATOM   5523 C CE2 . PHE D 4 77  ? 131.110 140.276 113.976 1.00 34.47  ? 146 PHE B CE2 1 
ATOM   5524 C CZ  . PHE D 4 77  ? 129.774 140.562 114.034 1.00 34.47  ? 146 PHE B CZ  1 
ATOM   5525 N N   . GLY D 4 78  ? 132.628 142.048 117.634 1.00 34.58  ? 147 GLY B N   1 
ATOM   5526 C CA  . GLY D 4 78  ? 133.118 140.889 118.343 1.00 34.58  ? 147 GLY B CA  1 
ATOM   5527 C C   . GLY D 4 78  ? 132.080 139.791 118.295 1.00 34.58  ? 147 GLY B C   1 
ATOM   5528 O O   . GLY D 4 78  ? 130.977 139.982 117.795 1.00 34.58  ? 147 GLY B O   1 
ATOM   5529 N N   . SER D 4 79  ? 132.446 138.642 118.842 1.00 35.30  ? 148 SER B N   1 
ATOM   5530 C CA  . SER D 4 79  ? 131.645 137.446 118.655 1.00 35.30  ? 148 SER B CA  1 
ATOM   5531 C C   . SER D 4 79  ? 131.877 136.492 119.810 1.00 35.30  ? 148 SER B C   1 
ATOM   5532 O O   . SER D 4 79  ? 133.021 136.230 120.172 1.00 35.30  ? 148 SER B O   1 
ATOM   5533 C CB  . SER D 4 79  ? 132.012 136.778 117.333 1.00 35.30  ? 148 SER B CB  1 
ATOM   5534 O OG  . SER D 4 79  ? 133.320 136.253 117.377 1.00 35.30  ? 148 SER B OG  1 
ATOM   5535 N N   . TYR D 4 80  ? 130.797 135.960 120.370 1.00 35.71  ? 149 TYR B N   1 
ATOM   5536 C CA  . TYR D 4 80  ? 130.912 135.013 121.465 1.00 35.71  ? 149 TYR B CA  1 
ATOM   5537 C C   . TYR D 4 80  ? 129.871 133.926 121.297 1.00 35.71  ? 149 TYR B C   1 
ATOM   5538 O O   . TYR D 4 80  ? 128.792 134.167 120.762 1.00 35.71  ? 149 TYR B O   1 
ATOM   5539 C CB  . TYR D 4 80  ? 130.740 135.672 122.854 1.00 35.71  ? 149 TYR B CB  1 
ATOM   5540 C CG  . TYR D 4 80  ? 129.360 136.211 123.219 1.00 35.71  ? 149 TYR B CG  1 
ATOM   5541 C CD1 . TYR D 4 80  ? 129.027 137.520 122.969 1.00 35.71  ? 149 TYR B CD1 1 
ATOM   5542 C CD2 . TYR D 4 80  ? 128.411 135.412 123.849 1.00 35.71  ? 149 TYR B CD2 1 
ATOM   5543 C CE1 . TYR D 4 80  ? 127.794 138.014 123.306 1.00 35.71  ? 149 TYR B CE1 1 
ATOM   5544 C CE2 . TYR D 4 80  ? 127.172 135.895 124.165 1.00 35.71  ? 149 TYR B CE2 1 
ATOM   5545 C CZ  . TYR D 4 80  ? 126.877 137.198 123.905 1.00 35.71  ? 149 TYR B CZ  1 
ATOM   5546 O OH  . TYR D 4 80  ? 125.649 137.699 124.233 1.00 35.71  ? 149 TYR B OH  1 
ATOM   5547 N N   . VAL D 4 81  ? 130.184 132.730 121.793 1.00 38.23  ? 150 VAL B N   1 
ATOM   5548 C CA  . VAL D 4 81  ? 129.125 131.758 122.033 1.00 38.23  ? 150 VAL B CA  1 
ATOM   5549 C C   . VAL D 4 81  ? 129.111 131.364 123.504 1.00 38.23  ? 150 VAL B C   1 
ATOM   5550 O O   . VAL D 4 81  ? 128.222 131.790 124.248 1.00 38.23  ? 150 VAL B O   1 
ATOM   5551 C CB  . VAL D 4 81  ? 129.271 130.519 121.137 1.00 38.23  ? 150 VAL B CB  1 
ATOM   5552 C CG1 . VAL D 4 81  ? 128.190 129.523 121.447 1.00 38.23  ? 150 VAL B CG1 1 
ATOM   5553 C CG2 . VAL D 4 81  ? 129.159 130.918 119.727 1.00 38.23  ? 150 VAL B CG2 1 
ATOM   5554 N N   . ASP D 4 82  ? 130.146 130.657 123.956 1.00 38.88  ? 151 ASP B N   1 
ATOM   5555 C CA  . ASP D 4 82  ? 130.149 130.003 125.258 1.00 38.88  ? 151 ASP B CA  1 
ATOM   5556 C C   . ASP D 4 82  ? 131.543 129.429 125.436 1.00 38.88  ? 151 ASP B C   1 
ATOM   5557 O O   . ASP D 4 82  ? 132.352 129.449 124.509 1.00 38.88  ? 151 ASP B O   1 
ATOM   5558 C CB  . ASP D 4 82  ? 129.076 128.914 125.321 1.00 38.88  ? 151 ASP B CB  1 
ATOM   5559 C CG  . ASP D 4 82  ? 128.628 128.603 126.728 1.00 38.88  ? 151 ASP B CG  1 
ATOM   5560 O OD1 . ASP D 4 82  ? 129.231 129.130 127.683 1.00 38.88  ? 151 ASP B OD1 1 
ATOM   5561 O OD2 . ASP D 4 82  ? 127.634 127.859 126.872 1.00 38.88  ? 151 ASP B OD2 1 
ATOM   5562 N N   . LYS D 4 83  ? 131.824 128.919 126.630 1.00 39.47  ? 152 LYS B N   1 
ATOM   5563 C CA  . LYS D 4 83  ? 133.098 128.253 126.876 1.00 39.47  ? 152 LYS B CA  1 
ATOM   5564 C C   . LYS D 4 83  ? 133.135 126.916 126.148 1.00 39.47  ? 152 LYS B C   1 
ATOM   5565 O O   . LYS D 4 83  ? 132.147 126.177 126.145 1.00 39.47  ? 152 LYS B O   1 
ATOM   5566 C CB  . LYS D 4 83  ? 133.315 128.031 128.369 1.00 39.47  ? 152 LYS B CB  1 
ATOM   5567 C CG  . LYS D 4 83  ? 133.499 129.274 129.184 1.00 39.47  ? 152 LYS B CG  1 
ATOM   5568 C CD  . LYS D 4 83  ? 133.951 128.895 130.572 1.00 39.47  ? 152 LYS B CD  1 
ATOM   5569 C CE  . LYS D 4 83  ? 134.188 130.099 131.451 1.00 39.47  ? 152 LYS B CE  1 
ATOM   5570 N NZ  . LYS D 4 83  ? 135.335 130.908 130.990 1.00 39.47  ? 152 LYS B NZ  1 
ATOM   5571 N N   . THR D 4 84  ? 134.272 126.595 125.536 1.00 40.87  ? 153 THR B N   1 
ATOM   5572 C CA  . THR D 4 84  ? 134.353 125.436 124.646 1.00 40.87  ? 153 THR B CA  1 
ATOM   5573 C C   . THR D 4 84  ? 134.854 124.192 125.372 1.00 40.87  ? 153 THR B C   1 
ATOM   5574 O O   . THR D 4 84  ? 135.836 123.564 124.985 1.00 40.87  ? 153 THR B O   1 
ATOM   5575 C CB  . THR D 4 84  ? 135.238 125.740 123.450 1.00 40.87  ? 153 THR B CB  1 
ATOM   5576 O OG1 . THR D 4 84  ? 136.542 126.109 123.910 1.00 40.87  ? 153 THR B OG1 1 
ATOM   5577 C CG2 . THR D 4 84  ? 134.645 126.850 122.637 1.00 40.87  ? 153 THR B CG2 1 
ATOM   5578 N N   . VAL D 4 85  ? 134.142 123.837 126.441 1.00 38.86  ? 154 VAL B N   1 
ATOM   5579 C CA  . VAL D 4 85  ? 134.316 122.573 127.138 1.00 38.86  ? 154 VAL B CA  1 
ATOM   5580 C C   . VAL D 4 85  ? 132.938 122.001 127.412 1.00 38.86  ? 154 VAL B C   1 
ATOM   5581 O O   . VAL D 4 85  ? 131.933 122.706 127.383 1.00 38.86  ? 154 VAL B O   1 
ATOM   5582 C CB  . VAL D 4 85  ? 135.096 122.725 128.446 1.00 38.86  ? 154 VAL B CB  1 
ATOM   5583 C CG1 . VAL D 4 85  ? 136.547 122.988 128.178 1.00 38.86  ? 154 VAL B CG1 1 
ATOM   5584 C CG2 . VAL D 4 85  ? 134.533 123.869 129.214 1.00 38.86  ? 154 VAL B CG2 1 
ATOM   5585 N N   . SER D 4 86  ? 132.901 120.701 127.658 1.00 39.64  ? 155 SER B N   1 
ATOM   5586 C CA  . SER D 4 86  ? 131.665 120.015 128.000 1.00 39.64  ? 155 SER B CA  1 
ATOM   5587 C C   . SER D 4 86  ? 131.230 120.423 129.409 1.00 39.64  ? 155 SER B C   1 
ATOM   5588 O O   . SER D 4 86  ? 132.072 120.760 130.242 1.00 39.64  ? 155 SER B O   1 
ATOM   5589 C CB  . SER D 4 86  ? 131.898 118.507 127.909 1.00 39.64  ? 155 SER B CB  1 
ATOM   5590 O OG  . SER D 4 86  ? 130.744 117.739 128.157 1.00 39.64  ? 155 SER B OG  1 
ATOM   5591 N N   . PRO D 4 87  ? 129.918 120.417 129.712 1.00 40.34  ? 156 PRO B N   1 
ATOM   5592 C CA  . PRO D 4 87  ? 128.676 120.064 129.019 1.00 40.34  ? 156 PRO B CA  1 
ATOM   5593 C C   . PRO D 4 87  ? 128.074 121.202 128.230 1.00 40.34  ? 156 PRO B C   1 
ATOM   5594 O O   . PRO D 4 87  ? 126.915 121.138 127.831 1.00 40.34  ? 156 PRO B O   1 
ATOM   5595 C CB  . PRO D 4 87  ? 127.749 119.698 130.165 1.00 40.34  ? 156 PRO B CB  1 
ATOM   5596 C CG  . PRO D 4 87  ? 128.187 120.570 131.248 1.00 40.34  ? 156 PRO B CG  1 
ATOM   5597 C CD  . PRO D 4 87  ? 129.659 120.697 131.130 1.00 40.34  ? 156 PRO B CD  1 
ATOM   5598 N N   . TYR D 4 88  ? 128.869 122.244 128.014 1.00 41.40  ? 157 TYR B N   1 
ATOM   5599 C CA  . TYR D 4 88  ? 128.359 123.435 127.354 1.00 41.40  ? 157 TYR B CA  1 
ATOM   5600 C C   . TYR D 4 88  ? 128.218 123.196 125.865 1.00 41.40  ? 157 TYR B C   1 
ATOM   5601 O O   . TYR D 4 88  ? 127.128 123.345 125.304 1.00 41.40  ? 157 TYR B O   1 
ATOM   5602 C CB  . TYR D 4 88  ? 129.294 124.604 127.630 1.00 41.40  ? 157 TYR B CB  1 
ATOM   5603 C CG  . TYR D 4 88  ? 129.380 124.957 129.086 1.00 41.40  ? 157 TYR B CG  1 
ATOM   5604 C CD1 . TYR D 4 88  ? 128.322 124.708 129.947 1.00 41.40  ? 157 TYR B CD1 1 
ATOM   5605 C CD2 . TYR D 4 88  ? 130.544 125.474 129.615 1.00 41.40  ? 157 TYR B CD2 1 
ATOM   5606 C CE1 . TYR D 4 88  ? 128.407 124.997 131.272 1.00 41.40  ? 157 TYR B CE1 1 
ATOM   5607 C CE2 . TYR D 4 88  ? 130.636 125.771 130.947 1.00 41.40  ? 157 TYR B CE2 1 
ATOM   5608 C CZ  . TYR D 4 88  ? 129.562 125.527 131.765 1.00 41.40  ? 157 TYR B CZ  1 
ATOM   5609 O OH  . TYR D 4 88  ? 129.643 125.816 133.095 1.00 41.40  ? 157 TYR B OH  1 
ATOM   5610 N N   . ILE D 4 89  ? 129.307 122.799 125.216 1.00 42.12  ? 158 ILE B N   1 
ATOM   5611 C CA  . ILE D 4 89  ? 129.291 122.398 123.825 1.00 42.12  ? 158 ILE B CA  1 
ATOM   5612 C C   . ILE D 4 89  ? 129.417 120.887 123.781 1.00 42.12  ? 158 ILE B C   1 
ATOM   5613 O O   . ILE D 4 89  ? 129.716 120.238 124.778 1.00 42.12  ? 158 ILE B O   1 
ATOM   5614 C CB  . ILE D 4 89  ? 130.411 123.058 123.013 1.00 42.12  ? 158 ILE B CB  1 
ATOM   5615 C CG1 . ILE D 4 89  ? 131.763 122.523 123.459 1.00 42.12  ? 158 ILE B CG1 1 
ATOM   5616 C CG2 . ILE D 4 89  ? 130.387 124.546 123.223 1.00 42.12  ? 158 ILE B CG2 1 
ATOM   5617 C CD1 . ILE D 4 89  ? 132.868 122.829 122.496 1.00 42.12  ? 158 ILE B CD1 1 
ATOM   5618 N N   . SER D 4 90  ? 129.178 120.329 122.605 1.00 44.63  ? 159 SER B N   1 
ATOM   5619 C CA  . SER D 4 90  ? 129.282 118.896 122.393 1.00 44.63  ? 159 SER B CA  1 
ATOM   5620 C C   . SER D 4 90  ? 130.705 118.566 121.972 1.00 44.63  ? 159 SER B C   1 
ATOM   5621 O O   . SER D 4 90  ? 131.202 119.102 120.980 1.00 44.63  ? 159 SER B O   1 
ATOM   5622 C CB  . SER D 4 90  ? 128.284 118.429 121.337 1.00 44.63  ? 159 SER B CB  1 
ATOM   5623 O OG  . SER D 4 90  ? 128.351 117.032 121.157 1.00 44.63  ? 159 SER B OG  1 
ATOM   5624 N N   . ILE D 4 91  ? 131.362 117.701 122.734 1.00 45.33  ? 160 ILE B N   1 
ATOM   5625 C CA  . ILE D 4 91  ? 132.709 117.268 122.415 1.00 45.33  ? 160 ILE B CA  1 
ATOM   5626 C C   . ILE D 4 91  ? 132.700 115.986 121.585 1.00 45.33  ? 160 ILE B C   1 
ATOM   5627 O O   . ILE D 4 91  ? 133.722 115.316 121.470 1.00 45.33  ? 160 ILE B O   1 
ATOM   5628 C CB  . ILE D 4 91  ? 133.566 117.109 123.676 1.00 45.33  ? 160 ILE B CB  1 
ATOM   5629 C CG1 . ILE D 4 91  ? 132.930 116.097 124.626 1.00 45.33  ? 160 ILE B CG1 1 
ATOM   5630 C CG2 . ILE D 4 91  ? 133.765 118.449 124.350 1.00 45.33  ? 160 ILE B CG2 1 
ATOM   5631 C CD1 . ILE D 4 91  ? 133.816 115.716 125.776 1.00 45.33  ? 160 ILE B CD1 1 
ATOM   5632 N N   . HIS D 4 92  ? 131.599 115.645 121.029 1.00 47.49  ? 161 HIS B N   1 
ATOM   5633 C CA  . HIS D 4 92  ? 131.590 114.535 120.104 1.00 47.49  ? 161 HIS B CA  1 
ATOM   5634 C C   . HIS D 4 92  ? 131.676 115.068 118.692 1.00 47.49  ? 161 HIS B C   1 
ATOM   5635 O O   . HIS D 4 92  ? 130.990 116.048 118.374 1.00 47.49  ? 161 HIS B O   1 
ATOM   5636 C CB  . HIS D 4 92  ? 130.329 113.707 120.279 1.00 47.49  ? 161 HIS B CB  1 
ATOM   5637 C CG  . HIS D 4 92  ? 130.304 112.468 119.450 1.00 47.49  ? 161 HIS B CG  1 
ATOM   5638 N ND1 . HIS D 4 92  ? 129.619 112.383 118.262 1.00 47.49  ? 161 HIS B ND1 1 
ATOM   5639 C CD2 . HIS D 4 92  ? 130.925 111.279 119.614 1.00 47.49  ? 161 HIS B CD2 1 
ATOM   5640 C CE1 . HIS D 4 92  ? 129.781 111.176 117.753 1.00 47.49  ? 161 HIS B CE1 1 
ATOM   5641 N NE2 . HIS D 4 92  ? 130.575 110.490 118.549 1.00 47.49  ? 161 HIS B NE2 1 
ATOM   5642 N N   . PRO D 4 93  ? 132.518 114.475 117.838 1.00 49.51  ? 162 PRO B N   1 
ATOM   5643 C CA  . PRO D 4 93  ? 132.801 115.098 116.534 1.00 49.51  ? 162 PRO B CA  1 
ATOM   5644 C C   . PRO D 4 93  ? 131.643 115.124 115.549 1.00 49.51  ? 162 PRO B C   1 
ATOM   5645 O O   . PRO D 4 93  ? 131.351 116.197 115.017 1.00 49.51  ? 162 PRO B O   1 
ATOM   5646 C CB  . PRO D 4 93  ? 133.973 114.263 116.012 1.00 49.51  ? 162 PRO B CB  1 
ATOM   5647 C CG  . PRO D 4 93  ? 134.626 113.754 117.230 1.00 49.51  ? 162 PRO B CG  1 
ATOM   5648 C CD  . PRO D 4 93  ? 133.520 113.456 118.177 1.00 49.51  ? 162 PRO B CD  1 
ATOM   5649 N N   . GLU D 4 94  ? 130.968 114.010 115.274 1.00 51.54  ? 163 GLU B N   1 
ATOM   5650 C CA  . GLU D 4 94  ? 129.961 114.056 114.216 1.00 51.54  ? 163 GLU B CA  1 
ATOM   5651 C C   . GLU D 4 94  ? 128.620 114.556 114.734 1.00 51.54  ? 163 GLU B C   1 
ATOM   5652 O O   . GLU D 4 94  ? 127.676 114.726 113.958 1.00 51.54  ? 163 GLU B O   1 
ATOM   5653 C CB  . GLU D 4 94  ? 129.818 112.694 113.530 1.00 51.54  ? 163 GLU B CB  1 
ATOM   5654 N N   . ARG D 4 95  ? 128.506 114.789 116.039 1.00 50.38  ? 164 ARG B N   1 
ATOM   5655 C CA  . ARG D 4 95  ? 127.333 115.496 116.536 1.00 50.38  ? 164 ARG B CA  1 
ATOM   5656 C C   . ARG D 4 95  ? 127.418 116.975 116.207 1.00 50.38  ? 164 ARG B C   1 
ATOM   5657 O O   . ARG D 4 95  ? 126.390 117.648 116.091 1.00 50.38  ? 164 ARG B O   1 
ATOM   5658 C CB  . ARG D 4 95  ? 127.186 115.295 118.042 1.00 50.38  ? 164 ARG B CB  1 
ATOM   5659 N N   . ILE D 4 96  ? 128.637 117.493 116.067 1.00 50.44  ? 165 ILE B N   1 
ATOM   5660 C CA  . ILE D 4 96  ? 128.837 118.864 115.623 1.00 50.44  ? 165 ILE B CA  1 
ATOM   5661 C C   . ILE D 4 96  ? 128.396 119.024 114.178 1.00 50.44  ? 165 ILE B C   1 
ATOM   5662 O O   . ILE D 4 96  ? 127.702 119.986 113.826 1.00 50.44  ? 165 ILE B O   1 
ATOM   5663 C CB  . ILE D 4 96  ? 130.312 119.252 115.809 1.00 50.44  ? 165 ILE B CB  1 
ATOM   5664 C CG1 . ILE D 4 96  ? 130.673 119.190 117.285 1.00 50.44  ? 165 ILE B CG1 1 
ATOM   5665 C CG2 . ILE D 4 96  ? 130.598 120.622 115.229 1.00 50.44  ? 165 ILE B CG2 1 
ATOM   5666 C CD1 . ILE D 4 96  ? 129.875 120.156 118.128 1.00 50.44  ? 165 ILE B CD1 1 
ATOM   5667 N N   . HIS D 4 97  ? 128.769 118.068 113.324 1.00 50.65  ? 166 HIS B N   1 
ATOM   5668 C CA  . HIS D 4 97  ? 128.506 118.192 111.897 1.00 50.65  ? 166 HIS B CA  1 
ATOM   5669 C C   . HIS D 4 97  ? 127.037 117.985 111.586 1.00 50.65  ? 166 HIS B C   1 
ATOM   5670 O O   . HIS D 4 97  ? 126.523 118.530 110.608 1.00 50.65  ? 166 HIS B O   1 
ATOM   5671 C CB  . HIS D 4 97  ? 129.368 117.199 111.131 1.00 50.65  ? 166 HIS B CB  1 
ATOM   5672 C CG  . HIS D 4 97  ? 130.834 117.427 111.311 1.00 50.65  ? 166 HIS B CG  1 
ATOM   5673 N ND1 . HIS D 4 97  ? 131.495 118.495 110.745 1.00 50.65  ? 166 HIS B ND1 1 
ATOM   5674 C CD2 . HIS D 4 97  ? 131.768 116.728 111.996 1.00 50.65  ? 166 HIS B CD2 1 
ATOM   5675 C CE1 . HIS D 4 97  ? 132.773 118.443 111.073 1.00 50.65  ? 166 HIS B CE1 1 
ATOM   5676 N NE2 . HIS D 4 97  ? 132.965 117.380 111.832 1.00 50.65  ? 166 HIS B NE2 1 
ATOM   5677 N N   . ASN D 4 98  ? 126.344 117.205 112.405 1.00 51.22  ? 167 ASN B N   1 
ATOM   5678 C CA  . ASN D 4 98  ? 124.905 117.077 112.239 1.00 51.22  ? 167 ASN B CA  1 
ATOM   5679 C C   . ASN D 4 98  ? 124.191 118.333 112.711 1.00 51.22  ? 167 ASN B C   1 
ATOM   5680 O O   . ASN D 4 98  ? 123.139 118.695 112.176 1.00 51.22  ? 167 ASN B O   1 
ATOM   5681 C CB  . ASN D 4 98  ? 124.404 115.855 113.002 1.00 51.22  ? 167 ASN B CB  1 
ATOM   5682 C CG  . ASN D 4 98  ? 124.889 114.558 112.401 1.00 51.22  ? 167 ASN B CG  1 
ATOM   5683 O OD1 . ASN D 4 98  ? 124.901 114.391 111.184 1.00 51.22  ? 167 ASN B OD1 1 
ATOM   5684 N ND2 . ASN D 4 98  ? 125.297 113.629 113.253 1.00 51.22  ? 167 ASN B ND2 1 
ATOM   5685 N N   . GLN D 4 99  ? 124.903 118.794 113.754 1.00 52.51  ? 168 GLN B N   1 
ATOM   5686 C CA  . GLN D 4 99  ? 124.291 120.013 114.270 1.00 52.51  ? 168 GLN B CA  1 
ATOM   5687 C C   . GLN D 4 99  ? 124.525 121.180 113.323 1.00 52.51  ? 168 GLN B C   1 
ATOM   5688 O O   . GLN D 4 99  ? 123.646 122.031 113.149 1.00 52.51  ? 168 GLN B O   1 
ATOM   5689 C CB  . GLN D 4 99  ? 124.846 120.322 115.658 1.00 52.51  ? 168 GLN B CB  1 
ATOM   5690 N N   . CYS D 4 100 ? 125.552 121.443 112.676 1.00 51.12  ? 169 CYS B N   1 
ATOM   5691 C CA  . CYS D 4 100 ? 125.813 122.416 111.626 1.00 51.12  ? 169 CYS B CA  1 
ATOM   5692 C C   . CYS D 4 100 ? 124.948 122.187 110.401 1.00 51.12  ? 169 CYS B C   1 
ATOM   5693 O O   . CYS D 4 100 ? 124.453 123.144 109.808 1.00 51.12  ? 169 CYS B O   1 
ATOM   5694 C CB  . CYS D 4 100 ? 127.278 122.377 111.219 1.00 51.12  ? 169 CYS B CB  1 
ATOM   5695 S SG  . CYS D 4 100 ? 128.359 123.421 112.153 1.00 51.12  ? 169 CYS B SG  1 
ATOM   5696 N N   . SER D 4 101 ? 124.785 120.939 109.980 1.00 50.25  ? 170 SER B N   1 
ATOM   5697 C CA  . SER D 4 101 ? 124.098 120.694 108.720 1.00 50.25  ? 170 SER B CA  1 
ATOM   5698 C C   . SER D 4 101 ? 122.593 120.842 108.872 1.00 50.25  ? 170 SER B C   1 
ATOM   5699 O O   . SER D 4 101 ? 121.881 121.028 107.878 1.00 50.25  ? 170 SER B O   1 
ATOM   5700 C CB  . SER D 4 101 ? 124.450 119.310 108.189 1.00 50.25  ? 170 SER B CB  1 
ATOM   5701 O OG  . SER D 4 101 ? 123.771 119.042 106.977 1.00 50.25  ? 170 SER B OG  1 
ATOM   5702 N N   . ASP D 4 102 ? 122.099 120.844 110.095 1.00 51.31  ? 171 ASP B N   1 
ATOM   5703 C CA  . ASP D 4 102 ? 120.683 121.039 110.309 1.00 51.31  ? 171 ASP B CA  1 
ATOM   5704 C C   . ASP D 4 102 ? 120.332 122.437 109.913 1.00 51.31  ? 171 ASP B C   1 
ATOM   5705 O O   . ASP D 4 102 ? 119.486 122.638 109.062 1.00 51.31  ? 171 ASP B O   1 
ATOM   5706 C CB  . ASP D 4 102 ? 120.370 120.835 111.761 1.00 51.31  ? 171 ASP B CB  1 
ATOM   5707 N N   . TYR D 4 103 ? 120.964 123.417 110.531 1.00 50.46  ? 172 TYR B N   1 
ATOM   5708 C CA  . TYR D 4 103 ? 120.750 124.780 110.147 1.00 50.46  ? 172 TYR B CA  1 
ATOM   5709 C C   . TYR D 4 103 ? 121.262 124.835 108.745 1.00 50.46  ? 172 TYR B C   1 
ATOM   5710 O O   . TYR D 4 103 ? 122.343 124.344 108.457 1.00 50.46  ? 172 TYR B O   1 
ATOM   5711 C CB  . TYR D 4 103 ? 121.649 125.692 110.941 1.00 50.46  ? 172 TYR B CB  1 
ATOM   5712 C CG  . TYR D 4 103 ? 121.799 125.390 112.407 1.00 50.46  ? 172 TYR B CG  1 
ATOM   5713 C CD1 . TYR D 4 103 ? 120.696 125.243 113.230 1.00 50.46  ? 172 TYR B CD1 1 
ATOM   5714 C CD2 . TYR D 4 103 ? 123.054 125.303 112.977 1.00 50.46  ? 172 TYR B CD2 1 
ATOM   5715 C CE1 . TYR D 4 103 ? 120.842 124.979 114.573 1.00 50.46  ? 172 TYR B CE1 1 
ATOM   5716 C CE2 . TYR D 4 103 ? 123.211 125.046 114.318 1.00 50.46  ? 172 TYR B CE2 1 
ATOM   5717 C CZ  . TYR D 4 103 ? 122.102 124.885 115.110 1.00 50.46  ? 172 TYR B CZ  1 
ATOM   5718 O OH  . TYR D 4 103 ? 122.259 124.628 116.451 1.00 50.46  ? 172 TYR B OH  1 
ATOM   5719 N N   . ASN D 4 104 ? 120.533 125.464 107.852 1.00 46.51  ? 173 ASN B N   1 
ATOM   5720 C CA  . ASN D 4 104 ? 120.983 125.551 106.534 1.00 46.51  ? 173 ASN B CA  1 
ATOM   5721 C C   . ASN D 4 104 ? 121.649 126.894 106.476 1.00 46.51  ? 173 ASN B C   1 
ATOM   5722 O O   . ASN D 4 104 ? 121.204 127.761 105.748 1.00 46.51  ? 173 ASN B O   1 
ATOM   5723 C CB  . ASN D 4 104 ? 119.805 125.367 105.644 1.00 46.51  ? 173 ASN B CB  1 
ATOM   5724 C CG  . ASN D 4 104 ? 119.221 123.984 105.757 1.00 46.51  ? 173 ASN B CG  1 
ATOM   5725 O OD1 . ASN D 4 104 ? 118.011 123.807 105.738 1.00 46.51  ? 173 ASN B OD1 1 
ATOM   5726 N ND2 . ASN D 4 104 ? 120.085 122.992 105.892 1.00 46.51  ? 173 ASN B ND2 1 
ATOM   5727 N N   . LEU D 4 105 ? 122.741 127.065 107.189 1.00 43.18  ? 174 LEU B N   1 
ATOM   5728 C CA  . LEU D 4 105 ? 123.494 128.297 107.300 1.00 43.18  ? 174 LEU B CA  1 
ATOM   5729 C C   . LEU D 4 105 ? 124.960 127.933 107.424 1.00 43.18  ? 174 LEU B C   1 
ATOM   5730 O O   . LEU D 4 105 ? 125.300 126.837 107.861 1.00 43.18  ? 174 LEU B O   1 
ATOM   5731 C CB  . LEU D 4 105 ? 123.045 129.112 108.517 1.00 43.18  ? 174 LEU B CB  1 
ATOM   5732 C CG  . LEU D 4 105 ? 121.608 129.640 108.598 1.00 43.18  ? 174 LEU B CG  1 
ATOM   5733 C CD1 . LEU D 4 105 ? 121.328 130.223 109.961 1.00 43.18  ? 174 LEU B CD1 1 
ATOM   5734 C CD2 . LEU D 4 105 ? 121.343 130.661 107.511 1.00 43.18  ? 174 LEU B CD2 1 
ATOM   5735 N N   . ASP D 4 106 ? 125.830 128.855 107.033 1.00 42.07  ? 175 ASP B N   1 
ATOM   5736 C CA  . ASP D 4 106 ? 127.260 128.619 107.155 1.00 42.07  ? 175 ASP B CA  1 
ATOM   5737 C C   . ASP D 4 106 ? 127.671 128.637 108.617 1.00 42.07  ? 175 ASP B C   1 
ATOM   5738 O O   . ASP D 4 106 ? 127.386 129.590 109.339 1.00 42.07  ? 175 ASP B O   1 
ATOM   5739 C CB  . ASP D 4 106 ? 128.050 129.681 106.399 1.00 42.07  ? 175 ASP B CB  1 
ATOM   5740 C CG  . ASP D 4 106 ? 127.870 129.596 104.911 1.00 42.07  ? 175 ASP B CG  1 
ATOM   5741 O OD1 . ASP D 4 106 ? 127.610 128.497 104.391 1.00 42.07  ? 175 ASP B OD1 1 
ATOM   5742 O OD2 . ASP D 4 106 ? 128.008 130.637 104.247 1.00 42.07  ? 175 ASP B OD2 1 
ATOM   5743 N N   . CYS D 4 107 ? 128.354 127.584 109.057 1.00 43.61  ? 176 CYS B N   1 
ATOM   5744 C CA  . CYS D 4 107 ? 128.717 127.478 110.456 1.00 43.61  ? 176 CYS B CA  1 
ATOM   5745 C C   . CYS D 4 107 ? 130.223 127.409 110.603 1.00 43.61  ? 176 CYS B C   1 
ATOM   5746 O O   . CYS D 4 107 ? 130.947 127.097 109.660 1.00 43.61  ? 176 CYS B O   1 
ATOM   5747 C CB  . CYS D 4 107 ? 128.103 126.258 111.132 1.00 43.61  ? 176 CYS B CB  1 
ATOM   5748 S SG  . CYS D 4 107 ? 128.918 124.727 110.703 1.00 43.61  ? 176 CYS B SG  1 
ATOM   5749 N N   . MET D 4 108 ? 130.680 127.680 111.814 1.00 41.11  ? 177 MET B N   1 
ATOM   5750 C CA  . MET D 4 108 ? 132.084 127.682 112.187 1.00 41.11  ? 177 MET B CA  1 
ATOM   5751 C C   . MET D 4 108 ? 132.179 127.067 113.576 1.00 41.11  ? 177 MET B C   1 
ATOM   5752 O O   . MET D 4 108 ? 131.145 126.835 114.210 1.00 41.11  ? 177 MET B O   1 
ATOM   5753 C CB  . MET D 4 108 ? 132.649 129.110 112.138 1.00 41.11  ? 177 MET B CB  1 
ATOM   5754 C CG  . MET D 4 108 ? 132.157 130.056 113.171 1.00 41.11  ? 177 MET B CG  1 
ATOM   5755 S SD  . MET D 4 108 ? 133.025 131.599 112.958 1.00 41.11  ? 177 MET B SD  1 
ATOM   5756 C CE  . MET D 4 108 ? 132.342 132.501 114.307 1.00 41.11  ? 177 MET B CE  1 
ATOM   5757 N N   . PRO D 4 109 ? 133.384 126.715 114.046 1.00 41.54  ? 178 PRO B N   1 
ATOM   5758 C CA  . PRO D 4 109 ? 133.513 126.179 115.408 1.00 41.54  ? 178 PRO B CA  1 
ATOM   5759 C C   . PRO D 4 109 ? 133.058 127.171 116.461 1.00 41.54  ? 178 PRO B C   1 
ATOM   5760 O O   . PRO D 4 109 ? 133.245 128.387 116.303 1.00 41.54  ? 178 PRO B O   1 
ATOM   5761 C CB  . PRO D 4 109 ? 135.014 125.904 115.535 1.00 41.54  ? 178 PRO B CB  1 
ATOM   5762 C CG  . PRO D 4 109 ? 135.422 125.594 114.208 1.00 41.54  ? 178 PRO B CG  1 
ATOM   5763 C CD  . PRO D 4 109 ? 134.635 126.468 113.300 1.00 41.54  ? 178 PRO B CD  1 
ATOM   5764 N N   . PRO D 4 110 ? 132.436 126.690 117.535 1.00 38.13  ? 179 PRO B N   1 
ATOM   5765 C CA  . PRO D 4 110 ? 132.060 127.585 118.622 1.00 38.13  ? 179 PRO B CA  1 
ATOM   5766 C C   . PRO D 4 110 ? 133.289 128.055 119.354 1.00 38.13  ? 179 PRO B C   1 
ATOM   5767 O O   . PRO D 4 110 ? 134.350 127.437 119.296 1.00 38.13  ? 179 PRO B O   1 
ATOM   5768 C CB  . PRO D 4 110 ? 131.179 126.712 119.514 1.00 38.13  ? 179 PRO B CB  1 
ATOM   5769 C CG  . PRO D 4 110 ? 131.636 125.363 119.260 1.00 38.13  ? 179 PRO B CG  1 
ATOM   5770 C CD  . PRO D 4 110 ? 132.029 125.308 117.816 1.00 38.13  ? 179 PRO B CD  1 
ATOM   5771 N N   . HIS D 4 111 ? 133.136 129.170 120.043 1.00 35.94  ? 180 HIS B N   1 
ATOM   5772 C CA  . HIS D 4 111 ? 134.282 129.888 120.550 1.00 35.94  ? 180 HIS B CA  1 
ATOM   5773 C C   . HIS D 4 111 ? 133.861 130.679 121.769 1.00 35.94  ? 180 HIS B C   1 
ATOM   5774 O O   . HIS D 4 111 ? 132.689 131.012 121.936 1.00 35.94  ? 180 HIS B O   1 
ATOM   5775 C CB  . HIS D 4 111 ? 134.856 130.794 119.467 1.00 35.94  ? 180 HIS B CB  1 
ATOM   5776 C CG  . HIS D 4 111 ? 133.873 131.788 118.941 1.00 35.94  ? 180 HIS B CG  1 
ATOM   5777 N ND1 . HIS D 4 111 ? 132.883 131.450 118.049 1.00 35.94  ? 180 HIS B ND1 1 
ATOM   5778 C CD2 . HIS D 4 111 ? 133.736 133.110 119.171 1.00 35.94  ? 180 HIS B CD2 1 
ATOM   5779 C CE1 . HIS D 4 111 ? 132.163 132.517 117.770 1.00 35.94  ? 180 HIS B CE1 1 
ATOM   5780 N NE2 . HIS D 4 111 ? 132.666 133.539 118.430 1.00 35.94  ? 180 HIS B NE2 1 
ATOM   5781 N N   . GLY D 4 112 ? 134.823 130.953 122.630 1.00 34.82  ? 181 GLY B N   1 
ATOM   5782 C CA  . GLY D 4 112 ? 134.552 131.775 123.778 1.00 34.82  ? 181 GLY B CA  1 
ATOM   5783 C C   . GLY D 4 112 ? 134.325 133.199 123.353 1.00 34.82  ? 181 GLY B C   1 
ATOM   5784 O O   . GLY D 4 112 ? 133.235 133.732 123.530 1.00 34.82  ? 181 GLY B O   1 
ATOM   5785 N N   . TYR D 4 113 ? 135.344 133.808 122.762 1.00 35.03  ? 182 TYR B N   1 
ATOM   5786 C CA  . TYR D 4 113 ? 135.295 135.212 122.373 1.00 35.03  ? 182 TYR B CA  1 
ATOM   5787 C C   . TYR D 4 113 ? 136.365 135.477 121.330 1.00 35.03  ? 182 TYR B C   1 
ATOM   5788 O O   . TYR D 4 113 ? 137.548 135.269 121.595 1.00 35.03  ? 182 TYR B O   1 
ATOM   5789 C CB  . TYR D 4 113 ? 135.475 136.115 123.591 1.00 35.03  ? 182 TYR B CB  1 
ATOM   5790 C CG  . TYR D 4 113 ? 135.733 137.556 123.253 1.00 35.03  ? 182 TYR B CG  1 
ATOM   5791 C CD1 . TYR D 4 113 ? 134.794 138.310 122.577 1.00 35.03  ? 182 TYR B CD1 1 
ATOM   5792 C CD2 . TYR D 4 113 ? 136.904 138.167 123.642 1.00 35.03  ? 182 TYR B CD2 1 
ATOM   5793 C CE1 . TYR D 4 113 ? 135.036 139.611 122.272 1.00 35.03  ? 182 TYR B CE1 1 
ATOM   5794 C CE2 . TYR D 4 113 ? 137.141 139.470 123.350 1.00 35.03  ? 182 TYR B CE2 1 
ATOM   5795 C CZ  . TYR D 4 113 ? 136.207 140.184 122.669 1.00 35.03  ? 182 TYR B CZ  1 
ATOM   5796 O OH  . TYR D 4 113 ? 136.447 141.487 122.373 1.00 35.03  ? 182 TYR B OH  1 
ATOM   5797 N N   . ILE D 4 114 ? 135.950 135.943 120.157 1.00 34.06  ? 183 ILE B N   1 
ATOM   5798 C CA  . ILE D 4 114 ? 136.850 136.311 119.072 1.00 34.06  ? 183 ILE B CA  1 
ATOM   5799 C C   . ILE D 4 114 ? 136.631 137.780 118.757 1.00 34.06  ? 183 ILE B C   1 
ATOM   5800 O O   . ILE D 4 114 ? 135.519 138.185 118.409 1.00 34.06  ? 183 ILE B O   1 
ATOM   5801 C CB  . ILE D 4 114 ? 136.622 135.453 117.820 1.00 34.06  ? 183 ILE B CB  1 
ATOM   5802 C CG1 . ILE D 4 114 ? 136.994 134.005 118.083 1.00 34.06  ? 183 ILE B CG1 1 
ATOM   5803 C CG2 . ILE D 4 114 ? 137.433 135.971 116.665 1.00 34.06  ? 183 ILE B CG2 1 
ATOM   5804 C CD1 . ILE D 4 114 ? 136.595 133.085 116.969 1.00 34.06  ? 183 ILE B CD1 1 
ATOM   5805 N N   . HIS D 4 115 ? 137.681 138.574 118.881 1.00 34.58  ? 184 HIS B N   1 
ATOM   5806 C CA  . HIS D 4 115 ? 137.625 139.973 118.495 1.00 34.58  ? 184 HIS B CA  1 
ATOM   5807 C C   . HIS D 4 115 ? 137.889 140.101 117.006 1.00 34.58  ? 184 HIS B C   1 
ATOM   5808 O O   . HIS D 4 115 ? 138.966 139.741 116.528 1.00 34.58  ? 184 HIS B O   1 
ATOM   5809 C CB  . HIS D 4 115 ? 138.629 140.774 119.304 1.00 34.58  ? 184 HIS B CB  1 
ATOM   5810 C CG  . HIS D 4 115 ? 138.830 142.163 118.807 1.00 34.58  ? 184 HIS B CG  1 
ATOM   5811 N ND1 . HIS D 4 115 ? 137.820 143.091 118.763 1.00 34.58  ? 184 HIS B ND1 1 
ATOM   5812 C CD2 . HIS D 4 115 ? 139.947 142.803 118.396 1.00 34.58  ? 184 HIS B CD2 1 
ATOM   5813 C CE1 . HIS D 4 115 ? 138.297 144.234 118.314 1.00 34.58  ? 184 HIS B CE1 1 
ATOM   5814 N NE2 . HIS D 4 115 ? 139.585 144.085 118.079 1.00 34.58  ? 184 HIS B NE2 1 
ATOM   5815 N N   . VAL D 4 116 ? 136.907 140.620 116.275 1.00 33.78  ? 185 VAL B N   1 
ATOM   5816 C CA  . VAL D 4 116 ? 136.912 140.587 114.820 1.00 33.78  ? 185 VAL B CA  1 
ATOM   5817 C C   . VAL D 4 116 ? 137.457 141.883 114.253 1.00 33.78  ? 185 VAL B C   1 
ATOM   5818 O O   . VAL D 4 116 ? 138.468 141.887 113.547 1.00 33.78  ? 185 VAL B O   1 
ATOM   5819 C CB  . VAL D 4 116 ? 135.502 140.328 114.290 1.00 33.78  ? 185 VAL B CB  1 
ATOM   5820 C CG1 . VAL D 4 116 ? 135.498 140.381 112.797 1.00 33.78  ? 185 VAL B CG1 1 
ATOM   5821 C CG2 . VAL D 4 116 ? 135.004 139.005 114.779 1.00 33.78  ? 185 VAL B CG2 1 
ATOM   5822 N N   . LEU D 4 117 ? 136.790 142.991 114.558 1.00 34.65  ? 186 LEU B N   1 
ATOM   5823 C CA  . LEU D 4 117 ? 137.077 144.290 113.967 1.00 34.65  ? 186 LEU B CA  1 
ATOM   5824 C C   . LEU D 4 117 ? 137.358 145.270 115.085 1.00 34.65  ? 186 LEU B C   1 
ATOM   5825 O O   . LEU D 4 117 ? 136.556 145.391 116.010 1.00 34.65  ? 186 LEU B O   1 
ATOM   5826 C CB  . LEU D 4 117 ? 135.891 144.768 113.130 1.00 34.65  ? 186 LEU B CB  1 
ATOM   5827 C CG  . LEU D 4 117 ? 135.925 146.111 112.409 1.00 34.65  ? 186 LEU B CG  1 
ATOM   5828 C CD1 . LEU D 4 117 ? 136.966 146.127 111.319 1.00 34.65  ? 186 LEU B CD1 1 
ATOM   5829 C CD2 . LEU D 4 117 ? 134.568 146.398 111.850 1.00 34.65  ? 186 LEU B CD2 1 
ATOM   5830 N N   . SER D 4 118 ? 138.479 145.974 114.999 1.00 36.83  ? 187 SER B N   1 
ATOM   5831 C CA  . SER D 4 118 ? 138.736 147.039 115.949 1.00 36.83  ? 187 SER B CA  1 
ATOM   5832 C C   . SER D 4 118 ? 137.882 148.256 115.617 1.00 36.83  ? 187 SER B C   1 
ATOM   5833 O O   . SER D 4 118 ? 137.173 148.301 114.610 1.00 36.83  ? 187 SER B O   1 
ATOM   5834 C CB  . SER D 4 118 ? 140.212 147.420 115.961 1.00 36.83  ? 187 SER B CB  1 
ATOM   5835 O OG  . SER D 4 118 ? 141.006 146.384 116.497 1.00 36.83  ? 187 SER B OG  1 
ATOM   5836 N N   . LEU D 4 119 ? 137.956 149.260 116.483 1.00 37.29  ? 188 LEU B N   1 
ATOM   5837 C CA  . LEU D 4 119 ? 137.128 150.445 116.323 1.00 37.29  ? 188 LEU B CA  1 
ATOM   5838 C C   . LEU D 4 119 ? 137.648 151.293 115.176 1.00 37.29  ? 188 LEU B C   1 
ATOM   5839 O O   . LEU D 4 119 ? 138.800 151.733 115.193 1.00 37.29  ? 188 LEU B O   1 
ATOM   5840 C CB  . LEU D 4 119 ? 137.097 151.231 117.624 1.00 37.29  ? 188 LEU B CB  1 
ATOM   5841 C CG  . LEU D 4 119 ? 136.298 150.534 118.722 1.00 37.29  ? 188 LEU B CG  1 
ATOM   5842 C CD1 . LEU D 4 119 ? 136.549 151.202 120.020 1.00 37.29  ? 188 LEU B CD1 1 
ATOM   5843 C CD2 . LEU D 4 119 ? 134.824 150.588 118.419 1.00 37.29  ? 188 LEU B CD2 1 
ATOM   5844 N N   . THR D 4 120 ? 136.805 151.510 114.170 1.00 39.08  ? 189 THR B N   1 
ATOM   5845 C CA  . THR D 4 120 ? 137.222 152.217 112.971 1.00 39.08  ? 189 THR B CA  1 
ATOM   5846 C C   . THR D 4 120 ? 136.038 152.969 112.387 1.00 39.08  ? 189 THR B C   1 
ATOM   5847 O O   . THR D 4 120 ? 134.879 152.604 112.588 1.00 39.08  ? 189 THR B O   1 
ATOM   5848 C CB  . THR D 4 120 ? 137.827 151.255 111.938 1.00 39.08  ? 189 THR B CB  1 
ATOM   5849 O OG1 . THR D 4 120 ? 138.328 151.998 110.823 1.00 39.08  ? 189 THR B OG1 1 
ATOM   5850 C CG2 . THR D 4 120 ? 136.802 150.245 111.453 1.00 39.08  ? 189 THR B CG2 1 
ATOM   5851 N N   . GLU D 4 121 ? 136.346 154.040 111.663 1.00 40.52  ? 190 GLU B N   1 
ATOM   5852 C CA  . GLU D 4 121 ? 135.331 154.893 111.068 1.00 40.52  ? 190 GLU B CA  1 
ATOM   5853 C C   . GLU D 4 121 ? 135.006 154.497 109.638 1.00 40.52  ? 190 GLU B C   1 
ATOM   5854 O O   . GLU D 4 121 ? 134.322 155.248 108.938 1.00 40.52  ? 190 GLU B O   1 
ATOM   5855 C CB  . GLU D 4 121 ? 135.773 156.352 111.122 1.00 40.52  ? 190 GLU B CB  1 
ATOM   5856 N N   . ASN D 4 122 ? 135.481 153.341 109.189 1.00 40.72  ? 191 ASN B N   1 
ATOM   5857 C CA  . ASN D 4 122 ? 135.137 152.797 107.885 1.00 40.72  ? 191 ASN B CA  1 
ATOM   5858 C C   . ASN D 4 122 ? 133.937 151.883 108.062 1.00 40.72  ? 191 ASN B C   1 
ATOM   5859 O O   . ASN D 4 122 ? 134.033 150.850 108.723 1.00 40.72  ? 191 ASN B O   1 
ATOM   5860 C CB  . ASN D 4 122 ? 136.306 152.028 107.288 1.00 40.72  ? 191 ASN B CB  1 
ATOM   5861 C CG  . ASN D 4 122 ? 137.467 152.913 106.955 1.00 40.72  ? 191 ASN B CG  1 
ATOM   5862 O OD1 . ASN D 4 122 ? 137.292 154.021 106.463 1.00 40.72  ? 191 ASN B OD1 1 
ATOM   5863 N ND2 . ASN D 4 122 ? 138.669 152.430 107.216 1.00 40.72  ? 191 ASN B ND2 1 
ATOM   5864 N N   . ILE D 4 123 ? 132.805 152.259 107.475 1.00 42.03  ? 192 ILE B N   1 
ATOM   5865 C CA  . ILE D 4 123 ? 131.644 151.396 107.557 1.00 42.03  ? 192 ILE B CA  1 
ATOM   5866 C C   . ILE D 4 123 ? 131.730 150.266 106.552 1.00 42.03  ? 192 ILE B C   1 
ATOM   5867 O O   . ILE D 4 123 ? 130.929 149.328 106.606 1.00 42.03  ? 192 ILE B O   1 
ATOM   5868 C CB  . ILE D 4 123 ? 130.354 152.200 107.350 1.00 42.03  ? 192 ILE B CB  1 
ATOM   5869 C CG1 . ILE D 4 123 ? 130.328 152.799 105.951 1.00 42.03  ? 192 ILE B CG1 1 
ATOM   5870 C CG2 . ILE D 4 123 ? 130.248 153.294 108.383 1.00 42.03  ? 192 ILE B CG2 1 
ATOM   5871 C CD1 . ILE D 4 123 ? 129.002 153.420 105.583 1.00 42.03  ? 192 ILE B CD1 1 
ATOM   5872 N N   . THR D 4 124 ? 132.672 150.345 105.611 1.00 43.11  ? 193 THR B N   1 
ATOM   5873 C CA  . THR D 4 124 ? 132.890 149.249 104.680 1.00 43.11  ? 193 THR B CA  1 
ATOM   5874 C C   . THR D 4 124 ? 133.705 148.141 105.315 1.00 43.11  ? 193 THR B C   1 
ATOM   5875 O O   . THR D 4 124 ? 133.717 147.018 104.807 1.00 43.11  ? 193 THR B O   1 
ATOM   5876 C CB  . THR D 4 124 ? 133.587 149.756 103.428 1.00 43.11  ? 193 THR B CB  1 
ATOM   5877 O OG1 . THR D 4 124 ? 134.865 150.289 103.786 1.00 43.11  ? 193 THR B OG1 1 
ATOM   5878 C CG2 . THR D 4 124 ? 132.760 150.844 102.775 1.00 43.11  ? 193 THR B CG2 1 
ATOM   5879 N N   . GLU D 4 125 ? 134.416 148.441 106.402 1.00 41.36  ? 194 GLU B N   1 
ATOM   5880 C CA  . GLU D 4 125 ? 135.048 147.379 107.169 1.00 41.36  ? 194 GLU B CA  1 
ATOM   5881 C C   . GLU D 4 125 ? 134.059 146.736 108.120 1.00 41.36  ? 194 GLU B C   1 
ATOM   5882 O O   . GLU D 4 125 ? 134.261 145.601 108.557 1.00 41.36  ? 194 GLU B O   1 
ATOM   5883 C CB  . GLU D 4 125 ? 136.255 147.915 107.919 1.00 41.36  ? 194 GLU B CB  1 
ATOM   5884 C CG  . GLU D 4 125 ? 137.356 148.296 106.985 1.00 41.36  ? 194 GLU B CG  1 
ATOM   5885 C CD  . GLU D 4 125 ? 138.589 148.772 107.698 1.00 41.36  ? 194 GLU B CD  1 
ATOM   5886 O OE1 . GLU D 4 125 ? 138.542 148.912 108.936 1.00 41.36  ? 194 GLU B OE1 1 
ATOM   5887 O OE2 . GLU D 4 125 ? 139.613 149.007 107.021 1.00 41.36  ? 194 GLU B OE2 1 
ATOM   5888 N N   . PHE D 4 126 ? 132.982 147.439 108.452 1.00 38.30  ? 195 PHE B N   1 
ATOM   5889 C CA  . PHE D 4 126 ? 131.948 146.824 109.269 1.00 38.30  ? 195 PHE B CA  1 
ATOM   5890 C C   . PHE D 4 126 ? 131.105 145.893 108.425 1.00 38.30  ? 195 PHE B C   1 
ATOM   5891 O O   . PHE D 4 126 ? 130.585 144.894 108.918 1.00 38.30  ? 195 PHE B O   1 
ATOM   5892 C CB  . PHE D 4 126 ? 131.090 147.900 109.930 1.00 38.30  ? 195 PHE B CB  1 
ATOM   5893 C CG  . PHE D 4 126 ? 130.211 147.387 111.032 1.00 38.30  ? 195 PHE B CG  1 
ATOM   5894 C CD1 . PHE D 4 126 ? 130.746 147.068 112.258 1.00 38.30  ? 195 PHE B CD1 1 
ATOM   5895 C CD2 . PHE D 4 126 ? 128.856 147.241 110.850 1.00 38.30  ? 195 PHE B CD2 1 
ATOM   5896 C CE1 . PHE D 4 126 ? 129.950 146.609 113.269 1.00 38.30  ? 195 PHE B CE1 1 
ATOM   5897 C CE2 . PHE D 4 126 ? 128.064 146.782 111.869 1.00 38.30  ? 195 PHE B CE2 1 
ATOM   5898 C CZ  . PHE D 4 126 ? 128.615 146.466 113.072 1.00 38.30  ? 195 PHE B CZ  1 
ATOM   5899 N N   . GLU D 4 127 ? 130.974 146.200 107.141 1.00 40.39  ? 196 GLU B N   1 
ATOM   5900 C CA  . GLU D 4 127 ? 130.211 145.336 106.255 1.00 40.39  ? 196 GLU B CA  1 
ATOM   5901 C C   . GLU D 4 127 ? 131.030 144.129 105.821 1.00 40.39  ? 196 GLU B C   1 
ATOM   5902 O O   . GLU D 4 127 ? 130.468 143.094 105.452 1.00 40.39  ? 196 GLU B O   1 
ATOM   5903 C CB  . GLU D 4 127 ? 129.726 146.135 105.049 1.00 40.39  ? 196 GLU B CB  1 
ATOM   5904 N N   . LYS D 4 128 ? 132.359 144.244 105.844 1.00 41.79  ? 197 LYS B N   1 
ATOM   5905 C CA  . LYS D 4 128 ? 133.203 143.065 105.694 1.00 41.79  ? 197 LYS B CA  1 
ATOM   5906 C C   . LYS D 4 128 ? 133.052 142.140 106.884 1.00 41.79  ? 197 LYS B C   1 
ATOM   5907 O O   . LYS D 4 128 ? 133.038 140.917 106.733 1.00 41.79  ? 197 LYS B O   1 
ATOM   5908 C CB  . LYS D 4 128 ? 134.669 143.461 105.557 1.00 41.79  ? 197 LYS B CB  1 
ATOM   5909 C CG  . LYS D 4 128 ? 135.101 144.018 104.234 1.00 41.79  ? 197 LYS B CG  1 
ATOM   5910 C CD  . LYS D 4 128 ? 136.565 144.388 104.324 1.00 41.79  ? 197 LYS B CD  1 
ATOM   5911 C CE  . LYS D 4 128 ? 137.418 143.144 104.483 1.00 41.79  ? 197 LYS B CE  1 
ATOM   5912 N NZ  . LYS D 4 128 ? 138.870 143.459 104.524 1.00 41.79  ? 197 LYS B NZ  1 
ATOM   5913 N N   . ALA D 4 129 ? 132.956 142.713 108.084 1.00 38.60  ? 198 ALA B N   1 
ATOM   5914 C CA  . ALA D 4 129 ? 132.925 141.914 109.299 1.00 38.60  ? 198 ALA B CA  1 
ATOM   5915 C C   . ALA D 4 129 ? 131.604 141.186 109.466 1.00 38.60  ? 198 ALA B C   1 
ATOM   5916 O O   . ALA D 4 129 ? 131.537 140.177 110.171 1.00 38.60  ? 198 ALA B O   1 
ATOM   5917 C CB  . ALA D 4 129 ? 133.190 142.807 110.500 1.00 38.60  ? 198 ALA B CB  1 
ATOM   5918 N N   . VAL D 4 130 ? 130.546 141.673 108.831 1.00 40.29  ? 199 VAL B N   1 
ATOM   5919 C CA  . VAL D 4 130 ? 129.237 141.058 108.985 1.00 40.29  ? 199 VAL B CA  1 
ATOM   5920 C C   . VAL D 4 130 ? 129.053 139.931 107.987 1.00 40.29  ? 199 VAL B C   1 
ATOM   5921 O O   . VAL D 4 130 ? 128.582 138.847 108.341 1.00 40.29  ? 199 VAL B O   1 
ATOM   5922 C CB  . VAL D 4 130 ? 128.140 142.132 108.865 1.00 40.29  ? 199 VAL B CB  1 
ATOM   5923 C CG1 . VAL D 4 130 ? 126.770 141.509 108.759 1.00 40.29  ? 199 VAL B CG1 1 
ATOM   5924 C CG2 . VAL D 4 130 ? 128.169 143.028 110.083 1.00 40.29  ? 199 VAL B CG2 1 
ATOM   5925 N N   . HIS D 4 131 ? 129.438 140.148 106.734 1.00 40.88  ? 200 HIS B N   1 
ATOM   5926 C CA  . HIS D 4 131 ? 129.276 139.109 105.728 1.00 40.88  ? 200 HIS B CA  1 
ATOM   5927 C C   . HIS D 4 131 ? 130.303 138.004 105.857 1.00 40.88  ? 200 HIS B C   1 
ATOM   5928 O O   . HIS D 4 131 ? 130.086 136.909 105.336 1.00 40.88  ? 200 HIS B O   1 
ATOM   5929 C CB  . HIS D 4 131 ? 129.334 139.713 104.336 1.00 40.88  ? 200 HIS B CB  1 
ATOM   5930 C CG  . HIS D 4 131 ? 128.056 140.349 103.912 1.00 40.88  ? 200 HIS B CG  1 
ATOM   5931 N ND1 . HIS D 4 131 ? 127.018 139.627 103.375 1.00 40.88  ? 200 HIS B ND1 1 
ATOM   5932 C CD2 . HIS D 4 131 ? 127.628 141.626 103.984 1.00 40.88  ? 200 HIS B CD2 1 
ATOM   5933 C CE1 . HIS D 4 131 ? 126.016 140.438 103.103 1.00 40.88  ? 200 HIS B CE1 1 
ATOM   5934 N NE2 . HIS D 4 131 ? 126.359 141.657 103.467 1.00 40.88  ? 200 HIS B NE2 1 
ATOM   5935 N N   . ARG D 4 132 ? 131.419 138.258 106.531 1.00 41.93  ? 201 ARG B N   1 
ATOM   5936 C CA  . ARG D 4 132 ? 132.341 137.174 106.822 1.00 41.93  ? 201 ARG B CA  1 
ATOM   5937 C C   . ARG D 4 132 ? 131.794 136.293 107.936 1.00 41.93  ? 201 ARG B C   1 
ATOM   5938 O O   . ARG D 4 132 ? 132.072 135.091 107.979 1.00 41.93  ? 201 ARG B O   1 
ATOM   5939 C CB  . ARG D 4 132 ? 133.709 137.744 107.187 1.00 41.93  ? 201 ARG B CB  1 
ATOM   5940 C CG  . ARG D 4 132 ? 134.791 136.704 107.379 1.00 41.93  ? 201 ARG B CG  1 
ATOM   5941 C CD  . ARG D 4 132 ? 136.151 137.306 107.644 1.00 41.93  ? 201 ARG B CD  1 
ATOM   5942 N NE  . ARG D 4 132 ? 136.710 137.950 106.463 1.00 41.93  ? 201 ARG B NE  1 
ATOM   5943 C CZ  . ARG D 4 132 ? 137.851 138.630 106.458 1.00 41.93  ? 201 ARG B CZ  1 
ATOM   5944 N NH1 . ARG D 4 132 ? 138.558 138.746 107.574 1.00 41.93  ? 201 ARG B NH1 1 
ATOM   5945 N NH2 . ARG D 4 132 ? 138.291 139.188 105.338 1.00 41.93  ? 201 ARG B NH2 1 
ATOM   5946 N N   . GLN D 4 133 ? 130.960 136.861 108.803 1.00 41.13  ? 202 GLN B N   1 
ATOM   5947 C CA  . GLN D 4 133 ? 130.558 136.221 110.049 1.00 41.13  ? 202 GLN B CA  1 
ATOM   5948 C C   . GLN D 4 133 ? 129.622 135.051 109.800 1.00 41.13  ? 202 GLN B C   1 
ATOM   5949 O O   . GLN D 4 133 ? 128.722 135.125 108.964 1.00 41.13  ? 202 GLN B O   1 
ATOM   5950 C CB  . GLN D 4 133 ? 129.880 137.250 110.957 1.00 41.13  ? 202 GLN B CB  1 
ATOM   5951 C CG  . GLN D 4 133 ? 129.611 136.774 112.359 1.00 41.13  ? 202 GLN B CG  1 
ATOM   5952 C CD  . GLN D 4 133 ? 130.885 136.515 113.110 1.00 41.13  ? 202 GLN B CD  1 
ATOM   5953 O OE1 . GLN D 4 133 ? 131.858 137.241 112.965 1.00 41.13  ? 202 GLN B OE1 1 
ATOM   5954 N NE2 . GLN D 4 133 ? 130.887 135.487 113.924 1.00 41.13  ? 202 GLN B NE2 1 
ATOM   5955 N N   . LYS D 4 134 ? 129.842 133.974 110.540 1.00 41.44  ? 203 LYS B N   1 
ATOM   5956 C CA  . LYS D 4 134 ? 129.107 132.730 110.409 1.00 41.44  ? 203 LYS B CA  1 
ATOM   5957 C C   . LYS D 4 134 ? 128.373 132.414 111.706 1.00 41.44  ? 203 LYS B C   1 
ATOM   5958 O O   . LYS D 4 134 ? 128.183 133.272 112.561 1.00 41.44  ? 203 LYS B O   1 
ATOM   5959 C CB  . LYS D 4 134 ? 130.036 131.591 109.996 1.00 41.44  ? 203 LYS B CB  1 
ATOM   5960 C CG  . LYS D 4 134 ? 130.469 131.691 108.557 1.00 41.44  ? 203 LYS B CG  1 
ATOM   5961 C CD  . LYS D 4 134 ? 131.285 130.498 108.141 1.00 41.44  ? 203 LYS B CD  1 
ATOM   5962 C CE  . LYS D 4 134 ? 132.654 130.580 108.749 1.00 41.44  ? 203 LYS B CE  1 
ATOM   5963 N NZ  . LYS D 4 134 ? 133.517 129.506 108.255 1.00 41.44  ? 203 LYS B NZ  1 
ATOM   5964 N N   . ILE D 4 135 ? 127.896 131.184 111.795 1.00 41.07  ? 204 ILE B N   1 
ATOM   5965 C CA  . ILE D 4 135 ? 127.037 130.693 112.866 1.00 41.07  ? 204 ILE B CA  1 
ATOM   5966 C C   . ILE D 4 135 ? 127.835 129.721 113.732 1.00 41.07  ? 204 ILE B C   1 
ATOM   5967 O O   . ILE D 4 135 ? 128.752 129.056 113.246 1.00 41.07  ? 204 ILE B O   1 
ATOM   5968 C CB  . ILE D 4 135 ? 125.788 130.047 112.226 1.00 41.07  ? 204 ILE B CB  1 
ATOM   5969 C CG1 . ILE D 4 135 ? 124.941 131.119 111.565 1.00 41.07  ? 204 ILE B CG1 1 
ATOM   5970 C CG2 . ILE D 4 135 ? 124.944 129.261 113.170 1.00 41.07  ? 204 ILE B CG2 1 
ATOM   5971 C CD1 . ILE D 4 135 ? 124.439 132.140 112.531 1.00 41.07  ? 204 ILE B CD1 1 
ATOM   5972 N N   . SER D 4 136 ? 127.548 129.684 115.032 1.00 40.87  ? 205 SER B N   1 
ATOM   5973 C CA  . SER D 4 136 ? 128.071 128.617 115.870 1.00 40.87  ? 205 SER B CA  1 
ATOM   5974 C C   . SER D 4 136 ? 126.986 128.159 116.824 1.00 40.87  ? 205 SER B C   1 
ATOM   5975 O O   . SER D 4 136 ? 125.800 128.351 116.546 1.00 40.87  ? 205 SER B O   1 
ATOM   5976 C CB  . SER D 4 136 ? 129.284 129.080 116.646 1.00 40.87  ? 205 SER B CB  1 
ATOM   5977 O OG  . SER D 4 136 ? 130.316 129.500 115.790 1.00 40.87  ? 205 SER B OG  1 
ATOM   5978 N N   . GLY D 4 137 ? 127.363 127.527 117.928 1.00 44.75  ? 206 GLY B N   1 
ATOM   5979 C CA  . GLY D 4 137 ? 126.384 127.214 118.953 1.00 44.75  ? 206 GLY B CA  1 
ATOM   5980 C C   . GLY D 4 137 ? 126.951 126.344 120.049 1.00 44.75  ? 206 GLY B C   1 
ATOM   5981 O O   . GLY D 4 137 ? 127.976 125.675 119.878 1.00 44.75  ? 206 GLY B O   1 
ATOM   5982 N N   . ASN D 4 138 ? 126.265 126.369 121.189 1.00 45.78  ? 207 ASN B N   1 
ATOM   5983 C CA  . ASN D 4 138 ? 126.478 125.424 122.271 1.00 45.78  ? 207 ASN B CA  1 
ATOM   5984 C C   . ASN D 4 138 ? 125.250 124.524 122.376 1.00 45.78  ? 207 ASN B C   1 
ATOM   5985 O O   . ASN D 4 138 ? 124.334 124.591 121.550 1.00 45.78  ? 207 ASN B O   1 
ATOM   5986 C CB  . ASN D 4 138 ? 126.789 126.137 123.598 1.00 45.78  ? 207 ASN B CB  1 
ATOM   5987 C CG  . ASN D 4 138 ? 125.713 127.132 124.024 1.00 45.78  ? 207 ASN B CG  1 
ATOM   5988 O OD1 . ASN D 4 138 ? 124.735 127.366 123.316 1.00 45.78  ? 207 ASN B OD1 1 
ATOM   5989 N ND2 . ASN D 4 138 ? 125.883 127.699 125.218 1.00 45.78  ? 207 ASN B ND2 1 
ATOM   5990 N N   . ILE D 4 139 ? 125.228 123.672 123.395 1.00 45.56  ? 208 ILE B N   1 
ATOM   5991 C CA  . ILE D 4 139 ? 124.120 122.736 123.561 1.00 45.56  ? 208 ILE B CA  1 
ATOM   5992 C C   . ILE D 4 139 ? 123.085 123.267 124.539 1.00 45.56  ? 208 ILE B C   1 
ATOM   5993 O O   . ILE D 4 139 ? 121.884 123.241 124.262 1.00 45.56  ? 208 ILE B O   1 
ATOM   5994 C CB  . ILE D 4 139 ? 124.646 121.359 124.002 1.00 45.56  ? 208 ILE B CB  1 
ATOM   5995 C CG1 . ILE D 4 139 ? 125.713 120.857 123.030 1.00 45.56  ? 208 ILE B CG1 1 
ATOM   5996 C CG2 . ILE D 4 139 ? 123.501 120.378 124.047 1.00 45.56  ? 208 ILE B CG2 1 
ATOM   5997 C CD1 . ILE D 4 139 ? 125.222 120.656 121.617 1.00 45.56  ? 208 ILE B CD1 1 
ATOM   5998 N N   . ASP D 4 140 ? 123.526 123.746 125.699 1.00 43.02  ? 209 ASP B N   1 
ATOM   5999 C CA  . ASP D 4 140 ? 122.622 124.368 126.650 1.00 43.02  ? 209 ASP B CA  1 
ATOM   6000 C C   . ASP D 4 140 ? 122.230 125.763 126.181 1.00 43.02  ? 209 ASP B C   1 
ATOM   6001 O O   . ASP D 4 140 ? 122.871 126.362 125.319 1.00 43.02  ? 209 ASP B O   1 
ATOM   6002 C CB  . ASP D 4 140 ? 123.237 124.400 128.053 1.00 43.02  ? 209 ASP B CB  1 
ATOM   6003 C CG  . ASP D 4 140 ? 124.569 125.111 128.113 1.00 43.02  ? 209 ASP B CG  1 
ATOM   6004 O OD1 . ASP D 4 140 ? 125.110 125.541 127.079 1.00 43.02  ? 209 ASP B OD1 1 
ATOM   6005 O OD2 . ASP D 4 140 ? 125.087 125.240 129.230 1.00 43.02  ? 209 ASP B OD2 1 
ATOM   6006 N N   . THR D 4 141 ? 121.169 126.278 126.762 1.00 39.66  ? 210 THR B N   1 
ATOM   6007 C CA  . THR D 4 141 ? 120.654 127.572 126.343 1.00 39.66  ? 210 THR B CA  1 
ATOM   6008 C C   . THR D 4 141 ? 121.423 128.826 126.784 1.00 39.66  ? 210 THR B C   1 
ATOM   6009 O O   . THR D 4 141 ? 121.481 129.755 125.975 1.00 39.66  ? 210 THR B O   1 
ATOM   6010 C CB  . THR D 4 141 ? 119.180 127.681 126.743 1.00 39.66  ? 210 THR B CB  1 
ATOM   6011 O OG1 . THR D 4 141 ? 119.012 127.406 128.136 1.00 39.66  ? 210 THR B OG1 1 
ATOM   6012 C CG2 . THR D 4 141 ? 118.357 126.698 125.944 1.00 39.66  ? 210 THR B CG2 1 
ATOM   6013 N N   . PRO D 4 142 ? 122.011 128.955 127.983 1.00 38.04  ? 211 PRO B N   1 
ATOM   6014 C CA  . PRO D 4 142 ? 122.718 130.203 128.287 1.00 38.04  ? 211 PRO B CA  1 
ATOM   6015 C C   . PRO D 4 142 ? 124.026 130.310 127.534 1.00 38.04  ? 211 PRO B C   1 
ATOM   6016 O O   . PRO D 4 142 ? 124.558 129.335 127.008 1.00 38.04  ? 211 PRO B O   1 
ATOM   6017 C CB  . PRO D 4 142 ? 122.972 130.119 129.789 1.00 38.04  ? 211 PRO B CB  1 
ATOM   6018 C CG  . PRO D 4 142 ? 122.063 129.172 130.256 1.00 38.04  ? 211 PRO B CG  1 
ATOM   6019 C CD  . PRO D 4 142 ? 121.934 128.158 129.215 1.00 38.04  ? 211 PRO B CD  1 
ATOM   6020 N N   . GLU D 4 143 ? 124.552 131.522 127.494 1.00 37.17  ? 212 GLU B N   1 
ATOM   6021 C CA  . GLU D 4 143 ? 125.677 131.817 126.637 1.00 37.17  ? 212 GLU B CA  1 
ATOM   6022 C C   . GLU D 4 143 ? 126.802 132.398 127.469 1.00 37.17  ? 212 GLU B C   1 
ATOM   6023 O O   . GLU D 4 143 ? 126.633 132.721 128.639 1.00 37.17  ? 212 GLU B O   1 
ATOM   6024 C CB  . GLU D 4 143 ? 125.277 132.790 125.527 1.00 37.17  ? 212 GLU B CB  1 
ATOM   6025 C CG  . GLU D 4 143 ? 124.129 132.315 124.643 1.00 37.17  ? 212 GLU B CG  1 
ATOM   6026 C CD  . GLU D 4 143 ? 124.464 131.111 123.799 1.00 37.17  ? 212 GLU B CD  1 
ATOM   6027 O OE1 . GLU D 4 143 ? 125.626 130.975 123.386 1.00 37.17  ? 212 GLU B OE1 1 
ATOM   6028 O OE2 . GLU D 4 143 ? 123.556 130.301 123.535 1.00 37.17  ? 212 GLU B OE2 1 
ATOM   6029 N N   . GLY D 4 144 ? 127.962 132.534 126.852 1.00 36.54  ? 213 GLY B N   1 
ATOM   6030 C CA  . GLY D 4 144 ? 129.093 133.116 127.535 1.00 36.54  ? 213 GLY B CA  1 
ATOM   6031 C C   . GLY D 4 144 ? 129.148 134.615 127.354 1.00 36.54  ? 213 GLY B C   1 
ATOM   6032 O O   . GLY D 4 144 ? 130.146 135.155 126.878 1.00 36.54  ? 213 GLY B O   1 
ATOM   6033 N N   . GLY D 4 145 ? 128.079 135.296 127.744 1.00 35.59  ? 214 GLY B N   1 
ATOM   6034 C CA  . GLY D 4 145 ? 127.953 136.715 127.517 1.00 35.59  ? 214 GLY B CA  1 
ATOM   6035 C C   . GLY D 4 145 ? 128.832 137.550 128.405 1.00 35.59  ? 214 GLY B C   1 
ATOM   6036 O O   . GLY D 4 145 ? 129.631 138.341 127.912 1.00 35.59  ? 214 GLY B O   1 
ATOM   6037 N N   . PHE D 4 146 ? 128.709 137.360 129.717 1.00 35.40  ? 215 PHE B N   1 
ATOM   6038 C CA  . PHE D 4 146 ? 129.412 138.199 130.679 1.00 35.40  ? 215 PHE B CA  1 
ATOM   6039 C C   . PHE D 4 146 ? 130.899 137.927 130.657 1.00 35.40  ? 215 PHE B C   1 
ATOM   6040 O O   . PHE D 4 146 ? 131.690 138.771 131.079 1.00 35.40  ? 215 PHE B O   1 
ATOM   6041 C CB  . PHE D 4 146 ? 128.874 137.942 132.083 1.00 35.40  ? 215 PHE B CB  1 
ATOM   6042 C CG  . PHE D 4 146 ? 127.423 138.294 132.263 1.00 35.40  ? 215 PHE B CG  1 
ATOM   6043 C CD1 . PHE D 4 146 ? 126.822 139.264 131.502 1.00 35.40  ? 215 PHE B CD1 1 
ATOM   6044 C CD2 . PHE D 4 146 ? 126.652 137.593 133.159 1.00 35.40  ? 215 PHE B CD2 1 
ATOM   6045 C CE1 . PHE D 4 146 ? 125.500 139.555 131.659 1.00 35.40  ? 215 PHE B CE1 1 
ATOM   6046 C CE2 . PHE D 4 146 ? 125.331 137.882 133.317 1.00 35.40  ? 215 PHE B CE2 1 
ATOM   6047 C CZ  . PHE D 4 146 ? 124.756 138.862 132.565 1.00 35.40  ? 215 PHE B CZ  1 
ATOM   6048 N N   . ASP D 4 147 ? 131.285 136.745 130.185 1.00 37.94  ? 216 ASP B N   1 
ATOM   6049 C CA  . ASP D 4 147 ? 132.692 136.395 130.070 1.00 37.94  ? 216 ASP B CA  1 
ATOM   6050 C C   . ASP D 4 147 ? 133.338 137.156 128.923 1.00 37.94  ? 216 ASP B C   1 
ATOM   6051 O O   . ASP D 4 147 ? 134.515 137.522 128.988 1.00 37.94  ? 216 ASP B O   1 
ATOM   6052 C CB  . ASP D 4 147 ? 132.814 134.884 129.875 1.00 37.94  ? 216 ASP B CB  1 
ATOM   6053 C CG  . ASP D 4 147 ? 134.166 134.357 130.251 1.00 37.94  ? 216 ASP B CG  1 
ATOM   6054 O OD1 . ASP D 4 147 ? 135.015 135.162 130.676 1.00 37.94  ? 216 ASP B OD1 1 
ATOM   6055 O OD2 . ASP D 4 147 ? 134.380 133.135 130.129 1.00 37.94  ? 216 ASP B OD2 1 
ATOM   6056 N N   . ALA D 4 148 ? 132.571 137.407 127.860 1.00 36.26  ? 217 ALA B N   1 
ATOM   6057 C CA  . ALA D 4 148 ? 133.089 138.153 126.723 1.00 36.26  ? 217 ALA B CA  1 
ATOM   6058 C C   . ALA D 4 148 ? 132.961 139.649 126.931 1.00 36.26  ? 217 ALA B C   1 
ATOM   6059 O O   . ALA D 4 148 ? 133.691 140.425 126.307 1.00 36.26  ? 217 ALA B O   1 
ATOM   6060 C CB  . ALA D 4 148 ? 132.364 137.739 125.452 1.00 36.26  ? 217 ALA B CB  1 
ATOM   6061 N N   . MET D 4 149 ? 132.031 140.069 127.791 1.00 35.02  ? 218 MET B N   1 
ATOM   6062 C CA  . MET D 4 149 ? 131.866 141.479 128.114 1.00 35.02  ? 218 MET B CA  1 
ATOM   6063 C C   . MET D 4 149 ? 133.045 142.002 128.907 1.00 35.02  ? 218 MET B C   1 
ATOM   6064 O O   . MET D 4 149 ? 133.393 143.179 128.808 1.00 35.02  ? 218 MET B O   1 
ATOM   6065 C CB  . MET D 4 149 ? 130.575 141.687 128.891 1.00 35.02  ? 218 MET B CB  1 
ATOM   6066 C CG  . MET D 4 149 ? 129.343 141.597 128.049 1.00 35.02  ? 218 MET B CG  1 
ATOM   6067 S SD  . MET D 4 149 ? 127.830 141.556 129.008 1.00 35.02  ? 218 MET B SD  1 
ATOM   6068 C CE  . MET D 4 149 ? 127.902 143.159 129.770 1.00 35.02  ? 218 MET B CE  1 
ATOM   6069 N N   . LEU D 4 150 ? 133.674 141.147 129.703 1.00 35.97  ? 219 LEU B N   1 
ATOM   6070 C CA  . LEU D 4 150 ? 134.827 141.597 130.467 1.00 35.97  ? 219 LEU B CA  1 
ATOM   6071 C C   . LEU D 4 150 ? 136.069 141.621 129.594 1.00 35.97  ? 219 LEU B C   1 
ATOM   6072 O O   . LEU D 4 150 ? 136.989 142.408 129.828 1.00 35.97  ? 219 LEU B O   1 
ATOM   6073 C CB  . LEU D 4 150 ? 135.023 140.707 131.695 1.00 35.97  ? 219 LEU B CB  1 
ATOM   6074 C CG  . LEU D 4 150 ? 135.936 141.194 132.823 1.00 35.97  ? 219 LEU B CG  1 
ATOM   6075 C CD1 . LEU D 4 150 ? 135.368 140.736 134.135 1.00 35.97  ? 219 LEU B CD1 1 
ATOM   6076 C CD2 . LEU D 4 150 ? 137.344 140.667 132.683 1.00 35.97  ? 219 LEU B CD2 1 
ATOM   6077 N N   . GLN D 4 151 ? 136.117 140.763 128.581 1.00 36.45  ? 220 GLN B N   1 
ATOM   6078 C CA  . GLN D 4 151 ? 137.261 140.771 127.683 1.00 36.45  ? 220 GLN B CA  1 
ATOM   6079 C C   . GLN D 4 151 ? 137.158 141.895 126.672 1.00 36.45  ? 220 GLN B C   1 
ATOM   6080 O O   . GLN D 4 151 ? 138.177 142.415 126.209 1.00 36.45  ? 220 GLN B O   1 
ATOM   6081 C CB  . GLN D 4 151 ? 137.387 139.422 126.997 1.00 36.45  ? 220 GLN B CB  1 
ATOM   6082 C CG  . GLN D 4 151 ? 137.838 138.366 127.956 1.00 36.45  ? 220 GLN B CG  1 
ATOM   6083 C CD  . GLN D 4 151 ? 139.248 138.616 128.407 1.00 36.45  ? 220 GLN B CD  1 
ATOM   6084 O OE1 . GLN D 4 151 ? 140.113 138.936 127.607 1.00 36.45  ? 220 GLN B OE1 1 
ATOM   6085 N NE2 . GLN D 4 151 ? 139.485 138.496 129.697 1.00 36.45  ? 220 GLN B NE2 1 
ATOM   6086 N N   . ALA D 4 152 ? 135.938 142.303 126.337 1.00 35.52  ? 221 ALA B N   1 
ATOM   6087 C CA  . ALA D 4 152 ? 135.760 143.497 125.530 1.00 35.52  ? 221 ALA B CA  1 
ATOM   6088 C C   . ALA D 4 152 ? 135.899 144.761 126.352 1.00 35.52  ? 221 ALA B C   1 
ATOM   6089 O O   . ALA D 4 152 ? 135.875 145.855 125.788 1.00 35.52  ? 221 ALA B O   1 
ATOM   6090 C CB  . ALA D 4 152 ? 134.401 143.474 124.848 1.00 35.52  ? 221 ALA B CB  1 
ATOM   6091 N N   . ALA D 4 153 ? 136.040 144.640 127.669 1.00 37.33  ? 222 ALA B N   1 
ATOM   6092 C CA  . ALA D 4 153 ? 136.176 145.814 128.513 1.00 37.33  ? 222 ALA B CA  1 
ATOM   6093 C C   . ALA D 4 153 ? 137.627 146.095 128.866 1.00 37.33  ? 222 ALA B C   1 
ATOM   6094 O O   . ALA D 4 153 ? 138.105 147.216 128.691 1.00 37.33  ? 222 ALA B O   1 
ATOM   6095 C CB  . ALA D 4 153 ? 135.347 145.651 129.782 1.00 37.33  ? 222 ALA B CB  1 
ATOM   6096 N N   . VAL D 4 154 ? 138.343 145.094 129.369 1.00 39.89  ? 223 VAL B N   1 
ATOM   6097 C CA  . VAL D 4 154 ? 139.657 145.362 129.937 1.00 39.89  ? 223 VAL B CA  1 
ATOM   6098 C C   . VAL D 4 154 ? 140.722 145.429 128.849 1.00 39.89  ? 223 VAL B C   1 
ATOM   6099 O O   . VAL D 4 154 ? 141.807 145.977 129.066 1.00 39.89  ? 223 VAL B O   1 
ATOM   6100 C CB  . VAL D 4 154 ? 139.973 144.301 131.009 1.00 39.89  ? 223 VAL B CB  1 
ATOM   6101 C CG1 . VAL D 4 154 ? 140.278 142.949 130.383 1.00 39.89  ? 223 VAL B CG1 1 
ATOM   6102 C CG2 . VAL D 4 154 ? 141.075 144.756 131.958 1.00 39.89  ? 223 VAL B CG2 1 
ATOM   6103 N N   . CYS D 4 155 ? 140.437 144.911 127.663 1.00 41.61  ? 224 CYS B N   1 
ATOM   6104 C CA  . CYS D 4 155 ? 141.427 144.854 126.594 1.00 41.61  ? 224 CYS B CA  1 
ATOM   6105 C C   . CYS D 4 155 ? 141.338 146.147 125.800 1.00 41.61  ? 224 CYS B C   1 
ATOM   6106 O O   . CYS D 4 155 ? 140.585 146.262 124.841 1.00 41.61  ? 224 CYS B O   1 
ATOM   6107 C CB  . CYS D 4 155 ? 141.190 143.628 125.726 1.00 41.61  ? 224 CYS B CB  1 
ATOM   6108 S SG  . CYS D 4 155 ? 141.414 142.073 126.622 1.00 41.61  ? 224 CYS B SG  1 
ATOM   6109 N N   . GLU D 4 156 ? 142.116 147.144 126.208 1.00 42.54  ? 225 GLU B N   1 
ATOM   6110 C CA  . GLU D 4 156 ? 141.948 148.477 125.648 1.00 42.54  ? 225 GLU B CA  1 
ATOM   6111 C C   . GLU D 4 156 ? 142.727 148.665 124.354 1.00 42.54  ? 225 GLU B C   1 
ATOM   6112 O O   . GLU D 4 156 ? 142.203 149.229 123.393 1.00 42.54  ? 225 GLU B O   1 
ATOM   6113 C CB  . GLU D 4 156 ? 142.360 149.533 126.675 1.00 42.54  ? 225 GLU B CB  1 
ATOM   6114 C CG  . GLU D 4 156 ? 142.083 150.950 126.228 1.00 42.54  ? 225 GLU B CG  1 
ATOM   6115 C CD  . GLU D 4 156 ? 142.448 151.976 127.278 1.00 42.54  ? 225 GLU B CD  1 
ATOM   6116 O OE1 . GLU D 4 156 ? 142.944 151.576 128.351 1.00 42.54  ? 225 GLU B OE1 1 
ATOM   6117 O OE2 . GLU D 4 156 ? 142.236 153.184 127.031 1.00 42.54  ? 225 GLU B OE2 1 
ATOM   6118 N N   . SER D 4 157 ? 143.971 148.195 124.304 1.00 41.61  ? 226 SER B N   1 
ATOM   6119 C CA  . SER D 4 157 ? 144.759 148.338 123.090 1.00 41.61  ? 226 SER B CA  1 
ATOM   6120 C C   . SER D 4 157 ? 144.409 147.308 122.030 1.00 41.61  ? 226 SER B C   1 
ATOM   6121 O O   . SER D 4 157 ? 144.975 147.359 120.938 1.00 41.61  ? 226 SER B O   1 
ATOM   6122 C CB  . SER D 4 157 ? 146.244 148.250 123.418 1.00 41.61  ? 226 SER B CB  1 
ATOM   6123 O OG  . SER D 4 157 ? 146.579 146.963 123.893 1.00 41.61  ? 226 SER B OG  1 
ATOM   6124 N N   . HIS D 4 158 ? 143.509 146.378 122.320 1.00 40.96  ? 227 HIS B N   1 
ATOM   6125 C CA  . HIS D 4 158 ? 143.058 145.392 121.355 1.00 40.96  ? 227 HIS B CA  1 
ATOM   6126 C C   . HIS D 4 158 ? 141.710 145.751 120.756 1.00 40.96  ? 227 HIS B C   1 
ATOM   6127 O O   . HIS D 4 158 ? 141.523 145.631 119.546 1.00 40.96  ? 227 HIS B O   1 
ATOM   6128 C CB  . HIS D 4 158 ? 142.988 144.015 122.015 1.00 40.96  ? 227 HIS B CB  1 
ATOM   6129 C CG  . HIS D 4 158 ? 144.318 143.491 122.456 1.00 40.96  ? 227 HIS B CG  1 
ATOM   6130 N ND1 . HIS D 4 158 ? 145.243 142.980 121.575 1.00 40.96  ? 227 HIS B ND1 1 
ATOM   6131 C CD2 . HIS D 4 158 ? 144.881 143.408 123.681 1.00 40.96  ? 227 HIS B CD2 1 
ATOM   6132 C CE1 . HIS D 4 158 ? 146.318 142.602 122.238 1.00 40.96  ? 227 HIS B CE1 1 
ATOM   6133 N NE2 . HIS D 4 158 ? 146.124 142.849 123.519 1.00 40.96  ? 227 HIS B NE2 1 
ATOM   6134 N N   . ILE D 4 159 ? 140.757 146.175 121.585 1.00 38.10  ? 228 ILE B N   1 
ATOM   6135 C CA  . ILE D 4 159 ? 139.507 146.704 121.059 1.00 38.10  ? 228 ILE B CA  1 
ATOM   6136 C C   . ILE D 4 159 ? 139.755 148.061 120.435 1.00 38.10  ? 228 ILE B C   1 
ATOM   6137 O O   . ILE D 4 159 ? 139.155 148.405 119.414 1.00 38.10  ? 228 ILE B O   1 
ATOM   6138 C CB  . ILE D 4 159 ? 138.442 146.774 122.168 1.00 38.10  ? 228 ILE B CB  1 
ATOM   6139 C CG1 . ILE D 4 159 ? 138.232 145.408 122.801 1.00 38.10  ? 228 ILE B CG1 1 
ATOM   6140 C CG2 . ILE D 4 159 ? 137.122 147.250 121.631 1.00 38.10  ? 228 ILE B CG2 1 
ATOM   6141 C CD1 . ILE D 4 159 ? 137.785 144.394 121.861 1.00 38.10  ? 228 ILE B CD1 1 
ATOM   6142 N N   . GLY D 4 160 ? 140.662 148.838 121.005 1.00 38.35  ? 229 GLY B N   1 
ATOM   6143 C CA  . GLY D 4 160 ? 141.032 150.098 120.407 1.00 38.35  ? 229 GLY B CA  1 
ATOM   6144 C C   . GLY D 4 160 ? 140.127 151.219 120.848 1.00 38.35  ? 229 GLY B C   1 
ATOM   6145 O O   . GLY D 4 160 ? 139.776 152.086 120.046 1.00 38.35  ? 229 GLY B O   1 
ATOM   6146 N N   . TRP D 4 161 ? 139.739 151.208 122.118 1.00 35.98  ? 230 TRP B N   1 
ATOM   6147 C CA  . TRP D 4 161 ? 138.922 152.276 122.661 1.00 35.98  ? 230 TRP B CA  1 
ATOM   6148 C C   . TRP D 4 161 ? 139.743 153.553 122.743 1.00 35.98  ? 230 TRP B C   1 
ATOM   6149 O O   . TRP D 4 161 ? 140.971 153.518 122.822 1.00 35.98  ? 230 TRP B O   1 
ATOM   6150 C CB  . TRP D 4 161 ? 138.419 151.936 124.056 1.00 35.98  ? 230 TRP B CB  1 
ATOM   6151 C CG  . TRP D 4 161 ? 137.616 150.691 124.238 1.00 35.98  ? 230 TRP B CG  1 
ATOM   6152 C CD1 . TRP D 4 161 ? 138.058 149.532 124.755 1.00 35.98  ? 230 TRP B CD1 1 
ATOM   6153 C CD2 . TRP D 4 161 ? 136.226 150.509 123.978 1.00 35.98  ? 230 TRP B CD2 1 
ATOM   6154 N NE1 . TRP D 4 161 ? 137.048 148.627 124.822 1.00 35.98  ? 230 TRP B NE1 1 
ATOM   6155 C CE2 . TRP D 4 161 ? 135.906 149.206 124.344 1.00 35.98  ? 230 TRP B CE2 1 
ATOM   6156 C CE3 . TRP D 4 161 ? 135.226 151.319 123.457 1.00 35.98  ? 230 TRP B CE3 1 
ATOM   6157 C CZ2 . TRP D 4 161 ? 134.628 148.689 124.209 1.00 35.98  ? 230 TRP B CZ2 1 
ATOM   6158 C CZ3 . TRP D 4 161 ? 133.957 150.802 123.330 1.00 35.98  ? 230 TRP B CZ3 1 
ATOM   6159 C CH2 . TRP D 4 161 ? 133.672 149.508 123.703 1.00 35.98  ? 230 TRP B CH2 1 
ATOM   6160 N N   . ARG D 4 162 ? 139.054 154.685 122.723 1.00 37.96  ? 231 ARG B N   1 
ATOM   6161 C CA  . ARG D 4 162 ? 139.676 155.989 122.885 1.00 37.96  ? 231 ARG B CA  1 
ATOM   6162 C C   . ARG D 4 162 ? 139.373 156.512 124.279 1.00 37.96  ? 231 ARG B C   1 
ATOM   6163 O O   . ARG D 4 162 ? 138.276 156.301 124.797 1.00 37.96  ? 231 ARG B O   1 
ATOM   6164 C CB  . ARG D 4 162 ? 139.161 156.979 121.837 1.00 37.96  ? 231 ARG B CB  1 
ATOM   6165 C CG  . ARG D 4 162 ? 139.551 156.661 120.407 1.00 37.96  ? 231 ARG B CG  1 
ATOM   6166 C CD  . ARG D 4 162 ? 138.932 157.639 119.424 1.00 37.96  ? 231 ARG B CD  1 
ATOM   6167 N NE  . ARG D 4 162 ? 137.491 157.469 119.319 1.00 37.96  ? 231 ARG B NE  1 
ATOM   6168 C CZ  . ARG D 4 162 ? 136.697 158.274 118.632 1.00 37.96  ? 231 ARG B CZ  1 
ATOM   6169 N NH1 . ARG D 4 162 ? 137.202 159.305 117.987 1.00 37.96  ? 231 ARG B NH1 1 
ATOM   6170 N NH2 . ARG D 4 162 ? 135.401 158.046 118.583 1.00 37.96  ? 231 ARG B NH2 1 
ATOM   6171 N N   . LYS D 4 163 ? 140.353 157.174 124.893 1.00 41.18  ? 232 LYS B N   1 
ATOM   6172 C CA  . LYS D 4 163 ? 140.105 157.821 126.177 1.00 41.18  ? 232 LYS B CA  1 
ATOM   6173 C C   . LYS D 4 163 ? 139.092 158.939 126.036 1.00 41.18  ? 232 LYS B C   1 
ATOM   6174 O O   . LYS D 4 163 ? 138.220 159.112 126.892 1.00 41.18  ? 232 LYS B O   1 
ATOM   6175 C CB  . LYS D 4 163 ? 141.400 158.379 126.759 1.00 41.18  ? 232 LYS B CB  1 
ATOM   6176 C CG  . LYS D 4 163 ? 142.384 157.368 127.262 1.00 41.18  ? 232 LYS B CG  1 
ATOM   6177 C CD  . LYS D 4 163 ? 141.904 156.765 128.549 1.00 41.18  ? 232 LYS B CD  1 
ATOM   6178 C CE  . LYS D 4 163 ? 142.953 155.853 129.134 1.00 41.18  ? 232 LYS B CE  1 
ATOM   6179 N NZ  . LYS D 4 163 ? 142.479 155.209 130.385 1.00 41.18  ? 232 LYS B NZ  1 
ATOM   6180 N N   . GLU D 4 164 ? 139.184 159.699 124.952 1.00 42.78  ? 233 GLU B N   1 
ATOM   6181 C CA  . GLU D 4 164 ? 138.401 160.915 124.778 1.00 42.78  ? 233 GLU B CA  1 
ATOM   6182 C C   . GLU D 4 164 ? 137.121 160.623 123.990 1.00 42.78  ? 233 GLU B C   1 
ATOM   6183 O O   . GLU D 4 164 ? 136.704 161.358 123.098 1.00 42.78  ? 233 GLU B O   1 
ATOM   6184 C CB  . GLU D 4 164 ? 139.272 161.979 124.118 1.00 42.78  ? 233 GLU B CB  1 
ATOM   6185 C CG  . GLU D 4 164 ? 139.819 161.639 122.712 1.00 42.78  ? 233 GLU B CG  1 
ATOM   6186 C CD  . GLU D 4 164 ? 141.120 160.864 122.721 1.00 42.78  ? 233 GLU B CD  1 
ATOM   6187 O OE1 . GLU D 4 164 ? 141.519 160.358 123.785 1.00 42.78  ? 233 GLU B OE1 1 
ATOM   6188 O OE2 . GLU D 4 164 ? 141.737 160.749 121.646 1.00 42.78  ? 233 GLU B OE2 1 
ATOM   6189 N N   . ALA D 4 165 ? 136.431 159.572 124.398 1.00 37.82  ? 234 ALA B N   1 
ATOM   6190 C CA  . ALA D 4 165 ? 135.276 159.173 123.621 1.00 37.82  ? 234 ALA B CA  1 
ATOM   6191 C C   . ALA D 4 165 ? 134.240 158.552 124.534 1.00 37.82  ? 234 ALA B C   1 
ATOM   6192 O O   . ALA D 4 165 ? 134.550 158.066 125.618 1.00 37.82  ? 234 ALA B O   1 
ATOM   6193 C CB  . ALA D 4 165 ? 135.666 158.198 122.515 1.00 37.82  ? 234 ALA B CB  1 
ATOM   6194 N N   . LYS D 4 166 ? 133.004 158.577 124.073 1.00 38.34  ? 235 LYS B N   1 
ATOM   6195 C CA  . LYS D 4 166 ? 131.903 157.940 124.770 1.00 38.34  ? 235 LYS B CA  1 
ATOM   6196 C C   . LYS D 4 166 ? 131.847 156.481 124.349 1.00 38.34  ? 235 LYS B C   1 
ATOM   6197 O O   . LYS D 4 166 ? 131.422 156.167 123.235 1.00 38.34  ? 235 LYS B O   1 
ATOM   6198 C CB  . LYS D 4 166 ? 130.591 158.643 124.445 1.00 38.34  ? 235 LYS B CB  1 
ATOM   6199 C CG  . LYS D 4 166 ? 129.421 158.115 125.212 1.00 38.34  ? 235 LYS B CG  1 
ATOM   6200 C CD  . LYS D 4 166 ? 129.586 158.427 126.666 1.00 38.34  ? 235 LYS B CD  1 
ATOM   6201 C CE  . LYS D 4 166 ? 129.472 159.903 126.888 1.00 38.34  ? 235 LYS B CE  1 
ATOM   6202 N NZ  . LYS D 4 166 ? 129.579 160.210 128.322 1.00 38.34  ? 235 LYS B NZ  1 
ATOM   6203 N N   . ARG D 4 167 ? 132.259 155.594 125.241 1.00 36.25  ? 236 ARG B N   1 
ATOM   6204 C CA  . ARG D 4 167 ? 132.451 154.189 124.920 1.00 36.25  ? 236 ARG B CA  1 
ATOM   6205 C C   . ARG D 4 167 ? 131.156 153.427 125.139 1.00 36.25  ? 236 ARG B C   1 
ATOM   6206 O O   . ARG D 4 167 ? 130.706 153.288 126.276 1.00 36.25  ? 236 ARG B O   1 
ATOM   6207 C CB  . ARG D 4 167 ? 133.549 153.616 125.798 1.00 36.25  ? 236 ARG B CB  1 
ATOM   6208 C CG  . ARG D 4 167 ? 134.875 154.228 125.570 1.00 36.25  ? 236 ARG B CG  1 
ATOM   6209 C CD  . ARG D 4 167 ? 135.836 153.649 126.542 1.00 36.25  ? 236 ARG B CD  1 
ATOM   6210 N NE  . ARG D 4 167 ? 137.168 154.176 126.347 1.00 36.25  ? 236 ARG B NE  1 
ATOM   6211 C CZ  . ARG D 4 167 ? 138.209 153.808 127.070 1.00 36.25  ? 236 ARG B CZ  1 
ATOM   6212 N NH1 . ARG D 4 167 ? 138.056 152.906 128.017 1.00 36.25  ? 236 ARG B NH1 1 
ATOM   6213 N NH2 . ARG D 4 167 ? 139.399 154.323 126.838 1.00 36.25  ? 236 ARG B NH2 1 
ATOM   6214 N N   . LEU D 4 168 ? 130.565 152.927 124.064 1.00 36.21  ? 237 LEU B N   1 
ATOM   6215 C CA  . LEU D 4 168 ? 129.345 152.143 124.138 1.00 36.21  ? 237 LEU B CA  1 
ATOM   6216 C C   . LEU D 4 168 ? 129.675 150.694 123.831 1.00 36.21  ? 237 LEU B C   1 
ATOM   6217 O O   . LEU D 4 168 ? 130.552 150.418 123.009 1.00 36.21  ? 237 LEU B O   1 
ATOM   6218 C CB  . LEU D 4 168 ? 128.297 152.640 123.149 1.00 36.21  ? 237 LEU B CB  1 
ATOM   6219 C CG  . LEU D 4 168 ? 127.780 154.068 123.205 1.00 36.21  ? 237 LEU B CG  1 
ATOM   6220 C CD1 . LEU D 4 168 ? 126.747 154.264 122.120 1.00 36.21  ? 237 LEU B CD1 1 
ATOM   6221 C CD2 . LEU D 4 168 ? 127.212 154.383 124.551 1.00 36.21  ? 237 LEU B CD2 1 
ATOM   6222 N N   . LEU D 4 169 ? 128.970 149.774 124.480 1.00 33.85  ? 238 LEU B N   1 
ATOM   6223 C CA  . LEU D 4 169 ? 129.146 148.342 124.265 1.00 33.85  ? 238 LEU B CA  1 
ATOM   6224 C C   . LEU D 4 169 ? 127.772 147.730 124.090 1.00 33.85  ? 238 LEU B C   1 
ATOM   6225 O O   . LEU D 4 169 ? 127.091 147.430 125.068 1.00 33.85  ? 238 LEU B O   1 
ATOM   6226 C CB  . LEU D 4 169 ? 129.902 147.700 125.418 1.00 33.85  ? 238 LEU B CB  1 
ATOM   6227 C CG  . LEU D 4 169 ? 130.177 146.201 125.328 1.00 33.85  ? 238 LEU B CG  1 
ATOM   6228 C CD1 . LEU D 4 169 ? 130.883 145.878 124.041 1.00 33.85  ? 238 LEU B CD1 1 
ATOM   6229 C CD2 . LEU D 4 169 ? 131.031 145.761 126.499 1.00 33.85  ? 238 LEU B CD2 1 
ATOM   6230 N N   . LEU D 4 170 ? 127.360 147.551 122.849 1.00 33.19  ? 239 LEU B N   1 
ATOM   6231 C CA  . LEU D 4 170 ? 126.075 146.943 122.563 1.00 33.19  ? 239 LEU B CA  1 
ATOM   6232 C C   . LEU D 4 170 ? 126.240 145.437 122.635 1.00 33.19  ? 239 LEU B C   1 
ATOM   6233 O O   . LEU D 4 170 ? 126.904 144.838 121.789 1.00 33.19  ? 239 LEU B O   1 
ATOM   6234 C CB  . LEU D 4 170 ? 125.546 147.364 121.199 1.00 33.19  ? 239 LEU B CB  1 
ATOM   6235 C CG  . LEU D 4 170 ? 124.175 146.732 120.990 1.00 33.19  ? 239 LEU B CG  1 
ATOM   6236 C CD1 . LEU D 4 170 ? 123.179 147.273 121.981 1.00 33.19  ? 239 LEU B CD1 1 
ATOM   6237 C CD2 . LEU D 4 170 ? 123.659 146.910 119.596 1.00 33.19  ? 239 LEU B CD2 1 
ATOM   6238 N N   . VAL D 4 171 ? 125.649 144.828 123.651 1.00 33.94  ? 240 VAL B N   1 
ATOM   6239 C CA  . VAL D 4 171 ? 125.598 143.381 123.774 1.00 33.94  ? 240 VAL B CA  1 
ATOM   6240 C C   . VAL D 4 171 ? 124.307 142.937 123.117 1.00 33.94  ? 240 VAL B C   1 
ATOM   6241 O O   . VAL D 4 171 ? 123.247 143.504 123.380 1.00 33.94  ? 240 VAL B O   1 
ATOM   6242 C CB  . VAL D 4 171 ? 125.665 142.942 125.242 1.00 33.94  ? 240 VAL B CB  1 
ATOM   6243 C CG1 . VAL D 4 171 ? 125.587 141.441 125.364 1.00 33.94  ? 240 VAL B CG1 1 
ATOM   6244 C CG2 . VAL D 4 171 ? 126.934 143.458 125.875 1.00 33.94  ? 240 VAL B CG2 1 
ATOM   6245 N N   . MET D 4 172 ? 124.396 141.948 122.251 1.00 37.31  ? 241 MET B N   1 
ATOM   6246 C CA  . MET D 4 172 ? 123.316 141.601 121.352 1.00 37.31  ? 241 MET B CA  1 
ATOM   6247 C C   . MET D 4 172 ? 123.075 140.104 121.426 1.00 37.31  ? 241 MET B C   1 
ATOM   6248 O O   . MET D 4 172 ? 123.906 139.322 120.961 1.00 37.31  ? 241 MET B O   1 
ATOM   6249 C CB  . MET D 4 172 ? 123.684 142.033 119.941 1.00 37.31  ? 241 MET B CB  1 
ATOM   6250 C CG  . MET D 4 172 ? 122.578 141.939 118.945 1.00 37.31  ? 241 MET B CG  1 
ATOM   6251 S SD  . MET D 4 172 ? 123.127 142.598 117.375 1.00 37.31  ? 241 MET B SD  1 
ATOM   6252 C CE  . MET D 4 172 ? 121.635 142.369 116.457 1.00 37.31  ? 241 MET B CE  1 
ATOM   6253 N N   . THR D 4 173 ? 121.943 139.705 121.997 1.00 37.45  ? 242 THR B N   1 
ATOM   6254 C CA  . THR D 4 173 ? 121.688 138.299 122.276 1.00 37.45  ? 242 THR B CA  1 
ATOM   6255 C C   . THR D 4 173 ? 120.193 138.064 122.366 1.00 37.45  ? 242 THR B C   1 
ATOM   6256 O O   . THR D 4 173 ? 119.391 138.965 122.139 1.00 37.45  ? 242 THR B O   1 
ATOM   6257 C CB  . THR D 4 173 ? 122.366 137.862 123.564 1.00 37.45  ? 242 THR B CB  1 
ATOM   6258 O OG1 . THR D 4 173 ? 122.113 136.472 123.774 1.00 37.45  ? 242 THR B OG1 1 
ATOM   6259 C CG2 . THR D 4 173 ? 121.830 138.651 124.728 1.00 37.45  ? 242 THR B CG2 1 
ATOM   6260 N N   . ASP D 4 174 ? 119.824 136.824 122.654 1.00 39.52  ? 243 ASP B N   1 
ATOM   6261 C CA  . ASP D 4 174 ? 118.434 136.492 122.926 1.00 39.52  ? 243 ASP B CA  1 
ATOM   6262 C C   . ASP D 4 174 ? 118.244 135.542 124.090 1.00 39.52  ? 243 ASP B C   1 
ATOM   6263 O O   . ASP D 4 174 ? 117.114 135.415 124.567 1.00 39.52  ? 243 ASP B O   1 
ATOM   6264 C CB  . ASP D 4 174 ? 117.754 135.899 121.686 1.00 39.52  ? 243 ASP B CB  1 
ATOM   6265 C CG  . ASP D 4 174 ? 118.468 134.681 121.143 1.00 39.52  ? 243 ASP B CG  1 
ATOM   6266 O OD1 . ASP D 4 174 ? 119.559 134.333 121.632 1.00 39.52  ? 243 ASP B OD1 1 
ATOM   6267 O OD2 . ASP D 4 174 ? 117.931 134.063 120.203 1.00 39.52  ? 243 ASP B OD2 1 
ATOM   6268 N N   . GLN D 4 175 ? 119.286 134.865 124.552 1.00 38.84  ? 244 GLN B N   1 
ATOM   6269 C CA  . GLN D 4 175 ? 119.238 134.022 125.732 1.00 38.84  ? 244 GLN B CA  1 
ATOM   6270 C C   . GLN D 4 175 ? 119.840 134.768 126.907 1.00 38.84  ? 244 GLN B C   1 
ATOM   6271 O O   . GLN D 4 175 ? 120.240 135.926 126.798 1.00 38.84  ? 244 GLN B O   1 
ATOM   6272 C CB  . GLN D 4 175 ? 119.986 132.707 125.500 1.00 38.84  ? 244 GLN B CB  1 
ATOM   6273 C CG  . GLN D 4 175 ? 119.349 131.810 124.479 1.00 38.84  ? 244 GLN B CG  1 
ATOM   6274 C CD  . GLN D 4 175 ? 118.007 131.298 124.931 1.00 38.84  ? 244 GLN B CD  1 
ATOM   6275 O OE1 . GLN D 4 175 ? 117.809 131.000 126.105 1.00 38.84  ? 244 GLN B OE1 1 
ATOM   6276 N NE2 . GLN D 4 175 ? 117.073 131.186 124.002 1.00 38.84  ? 244 GLN B NE2 1 
ATOM   6277 N N   . THR D 4 176 ? 119.902 134.086 128.042 1.00 36.96  ? 245 THR B N   1 
ATOM   6278 C CA  . THR D 4 176 ? 120.557 134.633 129.219 1.00 36.96  ? 245 THR B CA  1 
ATOM   6279 C C   . THR D 4 176 ? 122.042 134.327 129.141 1.00 36.96  ? 245 THR B C   1 
ATOM   6280 O O   . THR D 4 176 ? 122.560 133.908 128.106 1.00 36.96  ? 245 THR B O   1 
ATOM   6281 C CB  . THR D 4 176 ? 119.930 134.080 130.483 1.00 36.96  ? 245 THR B CB  1 
ATOM   6282 O OG1 . THR D 4 176 ? 120.019 132.657 130.469 1.00 36.96  ? 245 THR B OG1 1 
ATOM   6283 C CG2 . THR D 4 176 ? 118.509 134.463 130.535 1.00 36.96  ? 245 THR B CG2 1 
ATOM   6284 N N   . SER D 4 177 ? 122.750 134.529 130.236 1.00 36.45  ? 246 SER B N   1 
ATOM   6285 C CA  . SER D 4 177 ? 124.172 134.269 130.275 1.00 36.45  ? 246 SER B CA  1 
ATOM   6286 C C   . SER D 4 177 ? 124.508 133.433 131.493 1.00 36.45  ? 246 SER B C   1 
ATOM   6287 O O   . SER D 4 177 ? 123.828 133.505 132.516 1.00 36.45  ? 246 SER B O   1 
ATOM   6288 C CB  . SER D 4 177 ? 124.962 135.556 130.307 1.00 36.45  ? 246 SER B CB  1 
ATOM   6289 O OG  . SER D 4 177 ? 124.744 136.303 129.130 1.00 36.45  ? 246 SER B OG  1 
ATOM   6290 N N   . HIS D 4 178 ? 125.564 132.638 131.371 1.00 36.61  ? 247 HIS B N   1 
ATOM   6291 C CA  . HIS D 4 178 ? 126.060 131.877 132.501 1.00 36.61  ? 247 HIS B CA  1 
ATOM   6292 C C   . HIS D 4 178 ? 126.645 132.804 133.544 1.00 36.61  ? 247 HIS B C   1 
ATOM   6293 O O   . HIS D 4 178 ? 127.071 133.919 133.246 1.00 36.61  ? 247 HIS B O   1 
ATOM   6294 C CB  . HIS D 4 178 ? 127.129 130.880 132.075 1.00 36.61  ? 247 HIS B CB  1 
ATOM   6295 C CG  . HIS D 4 178 ? 126.617 129.744 131.254 1.00 36.61  ? 247 HIS B CG  1 
ATOM   6296 N ND1 . HIS D 4 178 ? 125.800 128.769 131.775 1.00 36.61  ? 247 HIS B ND1 1 
ATOM   6297 C CD2 . HIS D 4 178 ? 126.856 129.391 129.974 1.00 36.61  ? 247 HIS B CD2 1 
ATOM   6298 C CE1 . HIS D 4 178 ? 125.525 127.884 130.838 1.00 36.61  ? 247 HIS B CE1 1 
ATOM   6299 N NE2 . HIS D 4 178 ? 126.157 128.237 129.735 1.00 36.61  ? 247 HIS B NE2 1 
ATOM   6300 N N   . LEU D 4 179 ? 126.666 132.330 134.776 1.00 36.01  ? 248 LEU B N   1 
ATOM   6301 C CA  . LEU D 4 179 ? 127.171 133.094 135.895 1.00 36.01  ? 248 LEU B CA  1 
ATOM   6302 C C   . LEU D 4 179 ? 128.502 132.509 136.321 1.00 36.01  ? 248 LEU B C   1 
ATOM   6303 O O   . LEU D 4 179 ? 128.984 131.539 135.739 1.00 36.01  ? 248 LEU B O   1 
ATOM   6304 C CB  . LEU D 4 179 ? 126.171 133.078 137.037 1.00 36.01  ? 248 LEU B CB  1 
ATOM   6305 C CG  . LEU D 4 179 ? 124.761 133.546 136.723 1.00 36.01  ? 248 LEU B CG  1 
ATOM   6306 C CD1 . LEU D 4 179 ? 123.937 133.282 137.925 1.00 36.01  ? 248 LEU B CD1 1 
ATOM   6307 C CD2 . LEU D 4 179 ? 124.710 135.003 136.364 1.00 36.01  ? 248 LEU B CD2 1 
ATOM   6308 N N   . ALA D 4 180 ? 129.082 133.088 137.373 1.00 36.81  ? 249 ALA B N   1 
ATOM   6309 C CA  . ALA D 4 180 ? 130.450 132.761 137.759 1.00 36.81  ? 249 ALA B CA  1 
ATOM   6310 C C   . ALA D 4 180 ? 130.588 131.338 138.265 1.00 36.81  ? 249 ALA B C   1 
ATOM   6311 O O   . ALA D 4 180 ? 131.661 130.743 138.142 1.00 36.81  ? 249 ALA B O   1 
ATOM   6312 C CB  . ALA D 4 180 ? 130.939 133.730 138.829 1.00 36.81  ? 249 ALA B CB  1 
ATOM   6313 N N   . LEU D 4 181 ? 129.525 130.774 138.827 1.00 35.83  ? 250 LEU B N   1 
ATOM   6314 C CA  . LEU D 4 181 ? 129.596 129.450 139.412 1.00 35.83  ? 250 LEU B CA  1 
ATOM   6315 C C   . LEU D 4 181 ? 128.837 128.404 138.618 1.00 35.83  ? 250 LEU B C   1 
ATOM   6316 O O   . LEU D 4 181 ? 128.601 127.314 139.139 1.00 35.83  ? 250 LEU B O   1 
ATOM   6317 C CB  . LEU D 4 181 ? 129.088 129.488 140.851 1.00 35.83  ? 250 LEU B CB  1 
ATOM   6318 C CG  . LEU D 4 181 ? 129.968 130.308 141.785 1.00 35.83  ? 250 LEU B CG  1 
ATOM   6319 C CD1 . LEU D 4 181 ? 129.337 130.428 143.132 1.00 35.83  ? 250 LEU B CD1 1 
ATOM   6320 C CD2 . LEU D 4 181 ? 131.309 129.664 141.908 1.00 35.83  ? 250 LEU B CD2 1 
ATOM   6321 N N   . ASP D 4 182 ? 128.445 128.705 137.376 1.00 36.95  ? 251 ASP B N   1 
ATOM   6322 C CA  . ASP D 4 182 ? 128.018 127.655 136.456 1.00 36.95  ? 251 ASP B CA  1 
ATOM   6323 C C   . ASP D 4 182 ? 129.196 126.831 135.979 1.00 36.95  ? 251 ASP B C   1 
ATOM   6324 O O   . ASP D 4 182 ? 129.014 125.744 135.429 1.00 36.95  ? 251 ASP B O   1 
ATOM   6325 C CB  . ASP D 4 182 ? 127.320 128.235 135.226 1.00 36.95  ? 251 ASP B CB  1 
ATOM   6326 C CG  . ASP D 4 182 ? 125.969 128.797 135.532 1.00 36.95  ? 251 ASP B CG  1 
ATOM   6327 O OD1 . ASP D 4 182 ? 125.423 128.464 136.592 1.00 36.95  ? 251 ASP B OD1 1 
ATOM   6328 O OD2 . ASP D 4 182 ? 125.421 129.539 134.704 1.00 36.95  ? 251 ASP B OD2 1 
ATOM   6329 N N   . SER D 4 183 ? 130.406 127.347 136.155 1.00 37.72  ? 252 SER B N   1 
ATOM   6330 C CA  . SER D 4 183 ? 131.605 126.742 135.608 1.00 37.72  ? 252 SER B CA  1 
ATOM   6331 C C   . SER D 4 183 ? 131.985 125.443 136.293 1.00 37.72  ? 252 SER B C   1 
ATOM   6332 O O   . SER D 4 183 ? 132.843 124.717 135.786 1.00 37.72  ? 252 SER B O   1 
ATOM   6333 C CB  . SER D 4 183 ? 132.751 127.730 135.740 1.00 37.72  ? 252 SER B CB  1 
ATOM   6334 O OG  . SER D 4 183 ? 132.464 128.934 135.069 1.00 37.72  ? 252 SER B OG  1 
ATOM   6335 N N   . LYS D 4 184 ? 131.379 125.135 137.436 1.00 37.72  ? 253 LYS B N   1 
ATOM   6336 C CA  . LYS D 4 184 ? 131.745 123.951 138.195 1.00 37.72  ? 253 LYS B CA  1 
ATOM   6337 C C   . LYS D 4 184 ? 131.258 122.680 137.518 1.00 37.72  ? 253 LYS B C   1 
ATOM   6338 O O   . LYS D 4 184 ? 131.777 121.597 137.802 1.00 37.72  ? 253 LYS B O   1 
ATOM   6339 C CB  . LYS D 4 184 ? 131.187 124.091 139.614 1.00 37.72  ? 253 LYS B CB  1 
ATOM   6340 C CG  . LYS D 4 184 ? 131.733 123.128 140.651 1.00 37.72  ? 253 LYS B CG  1 
ATOM   6341 C CD  . LYS D 4 184 ? 131.165 123.445 142.008 1.00 37.72  ? 253 LYS B CD  1 
ATOM   6342 C CE  . LYS D 4 184 ? 131.638 122.460 143.040 1.00 37.72  ? 253 LYS B CE  1 
ATOM   6343 N NZ  . LYS D 4 184 ? 131.092 122.790 144.381 1.00 37.72  ? 253 LYS B NZ  1 
ATOM   6344 N N   . LEU D 4 185 ? 130.300 122.791 136.602 1.00 36.97  ? 254 LEU B N   1 
ATOM   6345 C CA  . LEU D 4 185 ? 129.893 121.653 135.799 1.00 36.97  ? 254 LEU B CA  1 
ATOM   6346 C C   . LEU D 4 185 ? 130.955 121.239 134.800 1.00 36.97  ? 254 LEU B C   1 
ATOM   6347 O O   . LEU D 4 185 ? 130.902 120.121 134.288 1.00 36.97  ? 254 LEU B O   1 
ATOM   6348 C CB  . LEU D 4 185 ? 128.626 121.979 135.044 1.00 36.97  ? 254 LEU B CB  1 
ATOM   6349 C CG  . LEU D 4 185 ? 127.458 122.396 135.899 1.00 36.97  ? 254 LEU B CG  1 
ATOM   6350 C CD1 . LEU D 4 185 ? 126.310 122.623 134.983 1.00 36.97  ? 254 LEU B CD1 1 
ATOM   6351 C CD2 . LEU D 4 185 ? 127.148 121.332 136.868 1.00 36.97  ? 254 LEU B CD2 1 
ATOM   6352 N N   . ALA D 4 186 ? 131.900 122.118 134.488 1.00 37.34  ? 255 ALA B N   1 
ATOM   6353 C CA  . ALA D 4 186 ? 133.001 121.804 133.596 1.00 37.34  ? 255 ALA B CA  1 
ATOM   6354 C C   . ALA D 4 186 ? 134.301 121.579 134.348 1.00 37.34  ? 255 ALA B C   1 
ATOM   6355 O O   . ALA D 4 186 ? 135.344 121.379 133.729 1.00 37.34  ? 255 ALA B O   1 
ATOM   6356 C CB  . ALA D 4 186 ? 133.174 122.916 132.568 1.00 37.34  ? 255 ALA B CB  1 
ATOM   6357 N N   . GLY D 4 187 ? 134.260 121.607 135.666 1.00 36.56  ? 256 GLY B N   1 
ATOM   6358 C CA  . GLY D 4 187 ? 135.466 121.480 136.437 1.00 36.56  ? 256 GLY B CA  1 
ATOM   6359 C C   . GLY D 4 187 ? 136.327 122.716 136.339 1.00 36.56  ? 256 GLY B C   1 
ATOM   6360 O O   . GLY D 4 187 ? 137.539 122.668 136.557 1.00 36.56  ? 256 GLY B O   1 
ATOM   6361 N N   . ILE D 4 188 ? 135.707 123.840 136.006 1.00 37.01  ? 257 ILE B N   1 
ATOM   6362 C CA  . ILE D 4 188 ? 136.400 125.113 135.913 1.00 37.01  ? 257 ILE B CA  1 
ATOM   6363 C C   . ILE D 4 188 ? 136.196 125.808 137.252 1.00 37.01  ? 257 ILE B C   1 
ATOM   6364 O O   . ILE D 4 188 ? 135.119 126.318 137.541 1.00 37.01  ? 257 ILE B O   1 
ATOM   6365 C CB  . ILE D 4 188 ? 135.878 125.946 134.748 1.00 37.01  ? 257 ILE B CB  1 
ATOM   6366 C CG1 . ILE D 4 188 ? 136.150 125.247 133.422 1.00 37.01  ? 257 ILE B CG1 1 
ATOM   6367 C CG2 . ILE D 4 188 ? 136.532 127.262 134.737 1.00 37.01  ? 257 ILE B CG2 1 
ATOM   6368 C CD1 . ILE D 4 188 ? 135.463 125.893 132.265 1.00 37.01  ? 257 ILE B CD1 1 
ATOM   6369 N N   . VAL D 4 189 ? 137.224 125.796 138.094 1.00 36.92  ? 258 VAL B N   1 
ATOM   6370 C CA  . VAL D 4 189 ? 137.055 126.223 139.476 1.00 36.92  ? 258 VAL B CA  1 
ATOM   6371 C C   . VAL D 4 189 ? 138.044 127.309 139.874 1.00 36.92  ? 258 VAL B C   1 
ATOM   6372 O O   . VAL D 4 189 ? 137.978 127.827 140.990 1.00 36.92  ? 258 VAL B O   1 
ATOM   6373 C CB  . VAL D 4 189 ? 137.160 125.026 140.434 1.00 36.92  ? 258 VAL B CB  1 
ATOM   6374 C CG1 . VAL D 4 189 ? 135.977 124.102 140.276 1.00 36.92  ? 258 VAL B CG1 1 
ATOM   6375 C CG2 . VAL D 4 189 ? 138.422 124.271 140.166 1.00 36.92  ? 258 VAL B CG2 1 
ATOM   6376 N N   . VAL D 4 190 ? 138.960 127.675 138.987 1.00 37.04  ? 259 VAL B N   1 
ATOM   6377 C CA  . VAL D 4 190 ? 139.846 128.792 139.302 1.00 37.04  ? 259 VAL B CA  1 
ATOM   6378 C C   . VAL D 4 190 ? 139.127 130.076 138.904 1.00 37.04  ? 259 VAL B C   1 
ATOM   6379 O O   . VAL D 4 190 ? 138.540 130.148 137.817 1.00 37.04  ? 259 VAL B O   1 
ATOM   6380 C CB  . VAL D 4 190 ? 141.232 128.613 138.653 1.00 37.04  ? 259 VAL B CB  1 
ATOM   6381 C CG1 . VAL D 4 190 ? 141.136 128.382 137.186 1.00 37.04  ? 259 VAL B CG1 1 
ATOM   6382 C CG2 . VAL D 4 190 ? 142.129 129.811 138.916 1.00 37.04  ? 259 VAL B CG2 1 
ATOM   6383 N N   . PRO D 4 191 ? 139.065 131.079 139.783 1.00 38.60  ? 260 PRO B N   1 
ATOM   6384 C CA  . PRO D 4 191 ? 138.215 132.237 139.510 1.00 38.60  ? 260 PRO B CA  1 
ATOM   6385 C C   . PRO D 4 191 ? 138.790 133.158 138.454 1.00 38.60  ? 260 PRO B C   1 
ATOM   6386 O O   . PRO D 4 191 ? 139.992 133.167 138.184 1.00 38.60  ? 260 PRO B O   1 
ATOM   6387 C CB  . PRO D 4 191 ? 138.124 132.935 140.868 1.00 38.60  ? 260 PRO B CB  1 
ATOM   6388 C CG  . PRO D 4 191 ? 139.308 132.512 141.578 1.00 38.60  ? 260 PRO B CG  1 
ATOM   6389 C CD  . PRO D 4 191 ? 139.568 131.112 141.164 1.00 38.60  ? 260 PRO B CD  1 
ATOM   6390 N N   . ASN D 4 192 ? 137.894 133.931 137.850 1.00 39.06  ? 261 ASN B N   1 
ATOM   6391 C CA  . ASN D 4 192 ? 138.249 134.846 136.779 1.00 39.06  ? 261 ASN B CA  1 
ATOM   6392 C C   . ASN D 4 192 ? 139.096 135.971 137.337 1.00 39.06  ? 261 ASN B C   1 
ATOM   6393 O O   . ASN D 4 192 ? 138.655 136.702 138.224 1.00 39.06  ? 261 ASN B O   1 
ATOM   6394 C CB  . ASN D 4 192 ? 136.977 135.395 136.148 1.00 39.06  ? 261 ASN B CB  1 
ATOM   6395 C CG  . ASN D 4 192 ? 137.224 136.057 134.836 1.00 39.06  ? 261 ASN B CG  1 
ATOM   6396 O OD1 . ASN D 4 192 ? 138.341 136.087 134.343 1.00 39.06  ? 261 ASN B OD1 1 
ATOM   6397 N ND2 . ASN D 4 192 ? 136.182 136.604 134.255 1.00 39.06  ? 261 ASN B ND2 1 
ATOM   6398 N N   . ASP D 4 193 ? 140.314 136.112 136.831 1.00 40.64  ? 262 ASP B N   1 
ATOM   6399 C CA  . ASP D 4 193 ? 141.216 137.061 137.460 1.00 40.64  ? 262 ASP B CA  1 
ATOM   6400 C C   . ASP D 4 193 ? 140.918 138.500 137.071 1.00 40.64  ? 262 ASP B C   1 
ATOM   6401 O O   . ASP D 4 193 ? 141.133 139.408 137.878 1.00 40.64  ? 262 ASP B O   1 
ATOM   6402 C CB  . ASP D 4 193 ? 142.670 136.705 137.152 1.00 40.64  ? 262 ASP B CB  1 
ATOM   6403 C CG  . ASP D 4 193 ? 142.974 136.657 135.675 1.00 40.64  ? 262 ASP B CG  1 
ATOM   6404 O OD1 . ASP D 4 193 ? 142.048 136.758 134.848 1.00 40.64  ? 262 ASP B OD1 1 
ATOM   6405 O OD2 . ASP D 4 193 ? 144.166 136.525 135.336 1.00 40.64  ? 262 ASP B OD2 1 
ATOM   6406 N N   . GLY D 4 194 ? 140.427 138.733 135.861 1.00 41.47  ? 263 GLY B N   1 
ATOM   6407 C CA  . GLY D 4 194 ? 140.107 140.076 135.432 1.00 41.47  ? 263 GLY B CA  1 
ATOM   6408 C C   . GLY D 4 194 ? 141.204 140.800 134.693 1.00 41.47  ? 263 GLY B C   1 
ATOM   6409 O O   . GLY D 4 194 ? 141.247 142.032 134.733 1.00 41.47  ? 263 GLY B O   1 
ATOM   6410 N N   . ASN D 4 195 ? 142.095 140.083 134.026 1.00 41.53  ? 264 ASN B N   1 
ATOM   6411 C CA  . ASN D 4 195 ? 143.110 140.675 133.176 1.00 41.53  ? 264 ASN B CA  1 
ATOM   6412 C C   . ASN D 4 195 ? 142.824 140.315 131.726 1.00 41.53  ? 264 ASN B C   1 
ATOM   6413 O O   . ASN D 4 195 ? 141.991 139.461 131.428 1.00 41.53  ? 264 ASN B O   1 
ATOM   6414 C CB  . ASN D 4 195 ? 144.498 140.198 133.594 1.00 41.53  ? 264 ASN B CB  1 
ATOM   6415 C CG  . ASN D 4 195 ? 144.899 140.721 134.938 1.00 41.53  ? 264 ASN B CG  1 
ATOM   6416 O OD1 . ASN D 4 195 ? 144.673 141.879 135.253 1.00 41.53  ? 264 ASN B OD1 1 
ATOM   6417 N ND2 . ASN D 4 195 ? 145.497 139.869 135.747 1.00 41.53  ? 264 ASN B ND2 1 
ATOM   6418 N N   . CYS D 4 196 ? 143.525 140.981 130.816 1.00 43.48  ? 265 CYS B N   1 
ATOM   6419 C CA  . CYS D 4 196 ? 143.280 140.791 129.394 1.00 43.48  ? 265 CYS B CA  1 
ATOM   6420 C C   . CYS D 4 196 ? 143.996 139.545 128.905 1.00 43.48  ? 265 CYS B C   1 
ATOM   6421 O O   . CYS D 4 196 ? 145.196 139.382 129.130 1.00 43.48  ? 265 CYS B O   1 
ATOM   6422 C CB  . CYS D 4 196 ? 143.742 142.010 128.601 1.00 43.48  ? 265 CYS B CB  1 
ATOM   6423 S SG  . CYS D 4 196 ? 143.428 141.902 126.818 1.00 43.48  ? 265 CYS B SG  1 
ATOM   6424 N N   . HIS D 4 197 ? 143.262 138.670 128.228 1.00 39.61  ? 266 HIS B N   1 
ATOM   6425 C CA  . HIS D 4 197 ? 143.799 137.396 127.780 1.00 39.61  ? 266 HIS B CA  1 
ATOM   6426 C C   . HIS D 4 197 ? 143.413 137.122 126.341 1.00 39.61  ? 266 HIS B C   1 
ATOM   6427 O O   . HIS D 4 197 ? 142.902 136.054 126.006 1.00 39.61  ? 266 HIS B O   1 
ATOM   6428 C CB  . HIS D 4 197 ? 143.341 136.260 128.678 1.00 39.61  ? 266 HIS B CB  1 
ATOM   6429 C CG  . HIS D 4 197 ? 143.870 136.349 130.071 1.00 39.61  ? 266 HIS B CG  1 
ATOM   6430 N ND1 . HIS D 4 197 ? 145.197 136.155 130.375 1.00 39.61  ? 266 HIS B ND1 1 
ATOM   6431 C CD2 . HIS D 4 197 ? 143.245 136.575 131.247 1.00 39.61  ? 266 HIS B CD2 1 
ATOM   6432 C CE1 . HIS D 4 197 ? 145.373 136.288 131.675 1.00 39.61  ? 266 HIS B CE1 1 
ATOM   6433 N NE2 . HIS D 4 197 ? 144.202 136.538 132.228 1.00 39.61  ? 266 HIS B NE2 1 
ATOM   6434 N N   . LEU D 4 198 ? 143.643 138.091 125.463 1.00 39.03  ? 267 LEU B N   1 
ATOM   6435 C CA  . LEU D 4 198 ? 143.537 137.886 124.026 1.00 39.03  ? 267 LEU B CA  1 
ATOM   6436 C C   . LEU D 4 198 ? 144.931 137.616 123.487 1.00 39.03  ? 267 LEU B C   1 
ATOM   6437 O O   . LEU D 4 198 ? 145.791 138.499 123.525 1.00 39.03  ? 267 LEU B O   1 
ATOM   6438 C CB  . LEU D 4 198 ? 142.939 139.100 123.325 1.00 39.03  ? 267 LEU B CB  1 
ATOM   6439 C CG  . LEU D 4 198 ? 141.514 139.510 123.635 1.00 39.03  ? 267 LEU B CG  1 
ATOM   6440 C CD1 . LEU D 4 198 ? 141.193 140.751 122.847 1.00 39.03  ? 267 LEU B CD1 1 
ATOM   6441 C CD2 . LEU D 4 198 ? 140.571 138.408 123.293 1.00 39.03  ? 267 LEU B CD2 1 
ATOM   6442 N N   . LYS D 4 199 ? 145.160 136.405 122.991 1.00 39.27  ? 268 LYS B N   1 
ATOM   6443 C CA  . LYS D 4 199 ? 146.473 136.091 122.449 1.00 39.27  ? 268 LYS B CA  1 
ATOM   6444 C C   . LYS D 4 199 ? 146.575 136.539 120.999 1.00 39.27  ? 268 LYS B C   1 
ATOM   6445 O O   . LYS D 4 199 ? 147.472 137.307 120.643 1.00 39.27  ? 268 LYS B O   1 
ATOM   6446 C CB  . LYS D 4 199 ? 146.770 134.599 122.577 1.00 39.27  ? 268 LYS B CB  1 
ATOM   6447 N N   . ASN D 4 200 ? 145.670 136.072 120.154 1.00 39.54  ? 269 ASN B N   1 
ATOM   6448 C CA  . ASN D 4 200 ? 145.642 136.471 118.755 1.00 39.54  ? 269 ASN B CA  1 
ATOM   6449 C C   . ASN D 4 200 ? 144.237 136.842 118.352 1.00 39.54  ? 269 ASN B C   1 
ATOM   6450 O O   . ASN D 4 200 ? 143.674 136.287 117.409 1.00 39.54  ? 269 ASN B O   1 
ATOM   6451 C CB  . ASN D 4 200 ? 146.192 135.378 117.858 1.00 39.54  ? 269 ASN B CB  1 
ATOM   6452 C CG  . ASN D 4 200 ? 147.686 135.229 117.984 1.00 39.54  ? 269 ASN B CG  1 
ATOM   6453 O OD1 . ASN D 4 200 ? 148.413 136.216 118.050 1.00 39.54  ? 269 ASN B OD1 1 
ATOM   6454 N ND2 . ASN D 4 200 ? 148.156 133.990 118.018 1.00 39.54  ? 269 ASN B ND2 1 
ATOM   6455 N N   . ASN D 4 201 ? 143.649 137.765 119.120 1.00 37.98  ? 270 ASN B N   1 
ATOM   6456 C CA  . ASN D 4 201 ? 142.241 138.161 119.059 1.00 37.98  ? 270 ASN B CA  1 
ATOM   6457 C C   . ASN D 4 201 ? 141.309 136.993 119.317 1.00 37.98  ? 270 ASN B C   1 
ATOM   6458 O O   . ASN D 4 201 ? 140.210 136.938 118.775 1.00 37.98  ? 270 ASN B O   1 
ATOM   6459 C CB  . ASN D 4 201 ? 141.873 138.847 117.740 1.00 37.98  ? 270 ASN B CB  1 
ATOM   6460 C CG  . ASN D 4 201 ? 142.467 140.221 117.615 1.00 37.98  ? 270 ASN B CG  1 
ATOM   6461 O OD1 . ASN D 4 201 ? 142.522 140.975 118.582 1.00 37.98  ? 270 ASN B OD1 1 
ATOM   6462 N ND2 . ASN D 4 201 ? 142.904 140.565 116.415 1.00 37.98  ? 270 ASN B ND2 1 
ATOM   6463 N N   . VAL D 4 202 ? 141.754 136.042 120.128 1.00 37.34  ? 271 VAL B N   1 
ATOM   6464 C CA  . VAL D 4 202 ? 140.935 134.955 120.641 1.00 37.34  ? 271 VAL B CA  1 
ATOM   6465 C C   . VAL D 4 202 ? 141.222 134.859 122.128 1.00 37.34  ? 271 VAL B C   1 
ATOM   6466 O O   . VAL D 4 202 ? 142.384 134.850 122.538 1.00 37.34  ? 271 VAL B O   1 
ATOM   6467 C CB  . VAL D 4 202 ? 141.234 133.617 119.938 1.00 37.34  ? 271 VAL B CB  1 
ATOM   6468 C CG1 . VAL D 4 202 ? 140.503 132.491 120.601 1.00 37.34  ? 271 VAL B CG1 1 
ATOM   6469 C CG2 . VAL D 4 202 ? 140.822 133.662 118.494 1.00 37.34  ? 271 VAL B CG2 1 
ATOM   6470 N N   . TYR D 4 203 ? 140.170 134.834 122.931 1.00 38.63  ? 272 TYR B N   1 
ATOM   6471 C CA  . TYR D 4 203 ? 140.308 134.720 124.374 1.00 38.63  ? 272 TYR B CA  1 
ATOM   6472 C C   . TYR D 4 203 ? 140.785 133.329 124.760 1.00 38.63  ? 272 TYR B C   1 
ATOM   6473 O O   . TYR D 4 203 ? 140.066 132.345 124.586 1.00 38.63  ? 272 TYR B O   1 
ATOM   6474 C CB  . TYR D 4 203 ? 138.970 135.079 125.015 1.00 38.63  ? 272 TYR B CB  1 
ATOM   6475 C CG  . TYR D 4 203 ? 138.819 134.839 126.490 1.00 38.63  ? 272 TYR B CG  1 
ATOM   6476 C CD1 . TYR D 4 203 ? 139.740 135.328 127.395 1.00 38.63  ? 272 TYR B CD1 1 
ATOM   6477 C CD2 . TYR D 4 203 ? 137.667 134.262 126.984 1.00 38.63  ? 272 TYR B CD2 1 
ATOM   6478 C CE1 . TYR D 4 203 ? 139.573 135.137 128.742 1.00 38.63  ? 272 TYR B CE1 1 
ATOM   6479 C CE2 . TYR D 4 203 ? 137.486 134.080 128.322 1.00 38.63  ? 272 TYR B CE2 1 
ATOM   6480 C CZ  . TYR D 4 203 ? 138.440 134.516 129.200 1.00 38.63  ? 272 TYR B CZ  1 
ATOM   6481 O OH  . TYR D 4 203 ? 138.254 134.338 130.545 1.00 38.63  ? 272 TYR B OH  1 
ATOM   6482 N N   . VAL D 4 204 ? 142.017 133.258 125.274 1.00 39.63  ? 273 VAL B N   1 
ATOM   6483 C CA  . VAL D 4 204 ? 142.720 131.998 125.490 1.00 39.63  ? 273 VAL B CA  1 
ATOM   6484 C C   . VAL D 4 204 ? 142.746 131.567 126.945 1.00 39.63  ? 273 VAL B C   1 
ATOM   6485 O O   . VAL D 4 204 ? 143.577 130.731 127.313 1.00 39.63  ? 273 VAL B O   1 
ATOM   6486 C CB  . VAL D 4 204 ? 144.157 132.070 124.947 1.00 39.63  ? 273 VAL B CB  1 
ATOM   6487 C CG1 . VAL D 4 204 ? 144.133 132.185 123.451 1.00 39.63  ? 273 VAL B CG1 1 
ATOM   6488 C CG2 . VAL D 4 204 ? 144.878 133.247 125.544 1.00 39.63  ? 273 VAL B CG2 1 
ATOM   6489 N N   . LYS D 4 205 ? 141.886 132.122 127.791 1.00 38.61  ? 274 LYS B N   1 
ATOM   6490 C CA  . LYS D 4 205 ? 141.581 131.523 129.080 1.00 38.61  ? 274 LYS B CA  1 
ATOM   6491 C C   . LYS D 4 205 ? 140.136 131.066 129.148 1.00 38.61  ? 274 LYS B C   1 
ATOM   6492 O O   . LYS D 4 205 ? 139.580 130.939 130.238 1.00 38.61  ? 274 LYS B O   1 
ATOM   6493 C CB  . LYS D 4 205 ? 141.871 132.492 130.215 1.00 38.61  ? 274 LYS B CB  1 
ATOM   6494 C CG  . LYS D 4 205 ? 143.296 132.897 130.310 1.00 38.61  ? 274 LYS B CG  1 
ATOM   6495 C CD  . LYS D 4 205 ? 144.171 131.775 130.779 1.00 38.61  ? 274 LYS B CD  1 
ATOM   6496 C CE  . LYS D 4 205 ? 145.582 132.270 130.978 1.00 38.61  ? 274 LYS B CE  1 
ATOM   6497 N NZ  . LYS D 4 205 ? 146.486 131.174 131.385 1.00 38.61  ? 274 LYS B NZ  1 
ATOM   6498 N N   . SER D 4 206 ? 139.513 130.823 128.000 1.00 38.43  ? 275 SER B N   1 
ATOM   6499 C CA  . SER D 4 206 ? 138.095 130.515 127.966 1.00 38.43  ? 275 SER B CA  1 
ATOM   6500 C C   . SER D 4 206 ? 137.781 129.109 128.437 1.00 38.43  ? 275 SER B C   1 
ATOM   6501 O O   . SER D 4 206 ? 136.610 128.785 128.616 1.00 38.43  ? 275 SER B O   1 
ATOM   6502 C CB  . SER D 4 206 ? 137.557 130.708 126.554 1.00 38.43  ? 275 SER B CB  1 
ATOM   6503 O OG  . SER D 4 206 ? 136.179 130.413 126.495 1.00 38.43  ? 275 SER B OG  1 
ATOM   6504 N N   . THR D 4 207 ? 138.777 128.258 128.609 1.00 39.71  ? 276 THR B N   1 
ATOM   6505 C CA  . THR D 4 207 ? 138.552 126.912 129.094 1.00 39.71  ? 276 THR B CA  1 
ATOM   6506 C C   . THR D 4 207 ? 139.227 126.661 130.427 1.00 39.71  ? 276 THR B C   1 
ATOM   6507 O O   . THR D 4 207 ? 139.088 125.568 130.981 1.00 39.71  ? 276 THR B O   1 
ATOM   6508 C CB  . THR D 4 207 ? 139.044 125.887 128.066 1.00 39.71  ? 276 THR B CB  1 
ATOM   6509 O OG1 . THR D 4 207 ? 140.436 126.092 127.821 1.00 39.71  ? 276 THR B OG1 1 
ATOM   6510 C CG2 . THR D 4 207 ? 138.300 126.040 126.771 1.00 39.71  ? 276 THR B CG2 1 
ATOM   6511 N N   . THR D 4 208 ? 139.952 127.635 130.959 1.00 39.64  ? 277 THR B N   1 
ATOM   6512 C CA  . THR D 4 208 ? 140.666 127.475 132.211 1.00 39.64  ? 277 THR B CA  1 
ATOM   6513 C C   . THR D 4 208 ? 140.055 128.288 133.337 1.00 39.64  ? 277 THR B C   1 
ATOM   6514 O O   . THR D 4 208 ? 139.711 127.724 134.371 1.00 39.64  ? 277 THR B O   1 
ATOM   6515 C CB  . THR D 4 208 ? 142.135 127.863 132.032 1.00 39.64  ? 277 THR B CB  1 
ATOM   6516 O OG1 . THR D 4 208 ? 142.221 129.249 131.698 1.00 39.64  ? 277 THR B OG1 1 
ATOM   6517 C CG2 . THR D 4 208 ? 142.761 127.058 130.920 1.00 39.64  ? 277 THR B CG2 1 
ATOM   6518 N N   . MET D 4 209 ? 139.906 129.597 133.168 1.00 39.94  ? 278 MET B N   1 
ATOM   6519 C CA  . MET D 4 209 ? 139.284 130.432 134.183 1.00 39.94  ? 278 MET B CA  1 
ATOM   6520 C C   . MET D 4 209 ? 137.782 130.454 133.984 1.00 39.94  ? 278 MET B C   1 
ATOM   6521 O O   . MET D 4 209 ? 137.263 129.998 132.965 1.00 39.94  ? 278 MET B O   1 
ATOM   6522 C CB  . MET D 4 209 ? 139.838 131.846 134.137 1.00 39.94  ? 278 MET B CB  1 
ATOM   6523 C CG  . MET D 4 209 ? 141.275 131.901 134.533 1.00 39.94  ? 278 MET B CG  1 
ATOM   6524 S SD  . MET D 4 209 ? 141.970 133.536 134.391 1.00 39.94  ? 278 MET B SD  1 
ATOM   6525 C CE  . MET D 4 209 ? 143.664 133.191 134.839 1.00 39.94  ? 278 MET B CE  1 
ATOM   6526 N N   . GLU D 4 210 ? 137.078 130.980 134.972 1.00 38.88  ? 279 GLU B N   1 
ATOM   6527 C CA  . GLU D 4 210 ? 135.635 130.832 134.969 1.00 38.88  ? 279 GLU B CA  1 
ATOM   6528 C C   . GLU D 4 210 ? 134.952 132.121 134.542 1.00 38.88  ? 279 GLU B C   1 
ATOM   6529 O O   . GLU D 4 210 ? 135.597 133.104 134.181 1.00 38.88  ? 279 GLU B O   1 
ATOM   6530 C CB  . GLU D 4 210 ? 135.159 130.366 136.338 1.00 38.88  ? 279 GLU B CB  1 
ATOM   6531 C CG  . GLU D 4 210 ? 135.303 131.339 137.472 1.00 38.88  ? 279 GLU B CG  1 
ATOM   6532 C CD  . GLU D 4 210 ? 135.031 130.679 138.813 1.00 38.88  ? 279 GLU B CD  1 
ATOM   6533 O OE1 . GLU D 4 210 ? 134.834 129.451 138.840 1.00 38.88  ? 279 GLU B OE1 1 
ATOM   6534 O OE2 . GLU D 4 210 ? 134.999 131.382 139.839 1.00 38.88  ? 279 GLU B OE2 1 
ATOM   6535 N N   . HIS D 4 211 ? 133.621 132.090 134.537 1.00 37.26  ? 280 HIS B N   1 
ATOM   6536 C CA  . HIS D 4 211 ? 132.854 133.274 134.219 1.00 37.26  ? 280 HIS B CA  1 
ATOM   6537 C C   . HIS D 4 211 ? 133.033 134.299 135.331 1.00 37.26  ? 280 HIS B C   1 
ATOM   6538 O O   . HIS D 4 211 ? 133.315 133.938 136.474 1.00 37.26  ? 280 HIS B O   1 
ATOM   6539 C CB  . HIS D 4 211 ? 131.377 132.939 134.075 1.00 37.26  ? 280 HIS B CB  1 
ATOM   6540 C CG  . HIS D 4 211 ? 131.059 131.996 132.962 1.00 37.26  ? 280 HIS B CG  1 
ATOM   6541 N ND1 . HIS D 4 211 ? 131.052 132.378 131.641 1.00 37.26  ? 280 HIS B ND1 1 
ATOM   6542 C CD2 . HIS D 4 211 ? 130.684 130.698 132.979 1.00 37.26  ? 280 HIS B CD2 1 
ATOM   6543 C CE1 . HIS D 4 211 ? 130.712 131.349 130.889 1.00 37.26  ? 280 HIS B CE1 1 
ATOM   6544 N NE2 . HIS D 4 211 ? 130.482 130.317 131.677 1.00 37.26  ? 280 HIS B NE2 1 
ATOM   6545 N N   . PRO D 4 212 ? 132.902 135.581 135.028 1.00 35.86  ? 281 PRO B N   1 
ATOM   6546 C CA  . PRO D 4 212 ? 132.958 136.584 136.082 1.00 35.86  ? 281 PRO B CA  1 
ATOM   6547 C C   . PRO D 4 212 ? 131.649 136.650 136.843 1.00 35.86  ? 281 PRO B C   1 
ATOM   6548 O O   . PRO D 4 212 ? 130.593 136.252 136.358 1.00 35.86  ? 281 PRO B O   1 
ATOM   6549 C CB  . PRO D 4 212 ? 133.207 137.880 135.316 1.00 35.86  ? 281 PRO B CB  1 
ATOM   6550 C CG  . PRO D 4 212 ? 132.647 137.633 134.022 1.00 35.86  ? 281 PRO B CG  1 
ATOM   6551 C CD  . PRO D 4 212 ? 132.886 136.212 133.707 1.00 35.86  ? 281 PRO B CD  1 
ATOM   6552 N N   . SER D 4 213 ? 131.742 137.151 138.065 1.00 37.17  ? 282 SER B N   1 
ATOM   6553 C CA  . SER D 4 213 ? 130.548 137.488 138.809 1.00 37.17  ? 282 SER B CA  1 
ATOM   6554 C C   . SER D 4 213 ? 130.037 138.845 138.354 1.00 37.17  ? 282 SER B C   1 
ATOM   6555 O O   . SER D 4 213 ? 130.685 139.547 137.579 1.00 37.17  ? 282 SER B O   1 
ATOM   6556 C CB  . SER D 4 213 ? 130.842 137.494 140.301 1.00 37.17  ? 282 SER B CB  1 
ATOM   6557 O OG  . SER D 4 213 ? 131.778 138.502 140.616 1.00 37.17  ? 282 SER B OG  1 
ATOM   6558 N N   . LEU D 4 214 ? 128.855 139.222 138.837 1.00 35.67  ? 283 LEU B N   1 
ATOM   6559 C CA  . LEU D 4 214 ? 128.333 140.531 138.476 1.00 35.67  ? 283 LEU B CA  1 
ATOM   6560 C C   . LEU D 4 214 ? 129.099 141.644 139.161 1.00 35.67  ? 283 LEU B C   1 
ATOM   6561 O O   . LEU D 4 214 ? 129.147 142.759 138.647 1.00 35.67  ? 283 LEU B O   1 
ATOM   6562 C CB  . LEU D 4 214 ? 126.853 140.640 138.806 1.00 35.67  ? 283 LEU B CB  1 
ATOM   6563 C CG  . LEU D 4 214 ? 125.920 139.790 137.967 1.00 35.67  ? 283 LEU B CG  1 
ATOM   6564 C CD1 . LEU D 4 214 ? 124.523 140.009 138.446 1.00 35.67  ? 283 LEU B CD1 1 
ATOM   6565 C CD2 . LEU D 4 214 ? 126.046 140.145 136.517 1.00 35.67  ? 283 LEU B CD2 1 
ATOM   6566 N N   . GLY D 4 215 ? 129.702 141.370 140.312 1.00 37.18  ? 284 GLY B N   1 
ATOM   6567 C CA  . GLY D 4 215 ? 130.564 142.361 140.924 1.00 37.18  ? 284 GLY B CA  1 
ATOM   6568 C C   . GLY D 4 215 ? 131.907 142.461 140.231 1.00 37.18  ? 284 GLY B C   1 
ATOM   6569 O O   . GLY D 4 215 ? 132.503 143.537 140.170 1.00 37.18  ? 284 GLY B O   1 
ATOM   6570 N N   . GLN D 4 216 ? 132.412 141.335 139.729 1.00 39.12  ? 285 GLN B N   1 
ATOM   6571 C CA  . GLN D 4 216 ? 133.643 141.336 138.947 1.00 39.12  ? 285 GLN B CA  1 
ATOM   6572 C C   . GLN D 4 216 ? 133.435 142.056 137.626 1.00 39.12  ? 285 GLN B C   1 
ATOM   6573 O O   . GLN D 4 216 ? 134.317 142.777 137.151 1.00 39.12  ? 285 GLN B O   1 
ATOM   6574 C CB  . GLN D 4 216 ? 134.095 139.893 138.707 1.00 39.12  ? 285 GLN B CB  1 
ATOM   6575 C CG  . GLN D 4 216 ? 135.393 139.697 137.928 1.00 39.12  ? 285 GLN B CG  1 
ATOM   6576 C CD  . GLN D 4 216 ? 136.632 140.056 138.721 1.00 39.12  ? 285 GLN B CD  1 
ATOM   6577 O OE1 . GLN D 4 216 ? 136.719 139.780 139.913 1.00 39.12  ? 285 GLN B OE1 1 
ATOM   6578 N NE2 . GLN D 4 216 ? 137.606 140.655 138.055 1.00 39.12  ? 285 GLN B NE2 1 
ATOM   6579 N N   . LEU D 4 217 ? 132.258 141.880 137.026 1.00 36.95  ? 286 LEU B N   1 
ATOM   6580 C CA  . LEU D 4 217 ? 131.967 142.509 135.747 1.00 36.95  ? 286 LEU B CA  1 
ATOM   6581 C C   . LEU D 4 217 ? 131.760 144.001 135.904 1.00 36.95  ? 286 LEU B C   1 
ATOM   6582 O O   . LEU D 4 217 ? 132.298 144.787 135.124 1.00 36.95  ? 286 LEU B O   1 
ATOM   6583 C CB  . LEU D 4 217 ? 130.734 141.868 135.119 1.00 36.95  ? 286 LEU B CB  1 
ATOM   6584 C CG  . LEU D 4 217 ? 130.331 142.363 133.735 1.00 36.95  ? 286 LEU B CG  1 
ATOM   6585 C CD1 . LEU D 4 217 ? 131.367 141.972 132.725 1.00 36.95  ? 286 LEU B CD1 1 
ATOM   6586 C CD2 . LEU D 4 217 ? 128.979 141.845 133.338 1.00 36.95  ? 286 LEU B CD2 1 
ATOM   6587 N N   . SER D 4 218 ? 131.003 144.412 136.922 1.00 36.88  ? 287 SER B N   1 
ATOM   6588 C CA  . SER D 4 218 ? 130.602 145.810 137.050 1.00 36.88  ? 287 SER B CA  1 
ATOM   6589 C C   . SER D 4 218 ? 131.761 146.690 137.483 1.00 36.88  ? 287 SER B C   1 
ATOM   6590 O O   . SER D 4 218 ? 131.795 147.880 137.170 1.00 36.88  ? 287 SER B O   1 
ATOM   6591 C CB  . SER D 4 218 ? 129.447 145.939 138.036 1.00 36.88  ? 287 SER B CB  1 
ATOM   6592 O OG  . SER D 4 218 ? 129.065 147.288 138.190 1.00 36.88  ? 287 SER B OG  1 
ATOM   6593 N N   . GLU D 4 219 ? 132.720 146.129 138.208 1.00 36.53  ? 288 GLU B N   1 
ATOM   6594 C CA  . GLU D 4 219 ? 133.876 146.918 138.601 1.00 36.53  ? 288 GLU B CA  1 
ATOM   6595 C C   . GLU D 4 219 ? 134.802 147.156 137.429 1.00 36.53  ? 288 GLU B C   1 
ATOM   6596 O O   . GLU D 4 219 ? 135.602 148.093 137.457 1.00 36.53  ? 288 GLU B O   1 
ATOM   6597 C CB  . GLU D 4 219 ? 134.634 146.226 139.727 1.00 36.53  ? 288 GLU B CB  1 
ATOM   6598 N N   . LYS D 4 220 ? 134.718 146.318 136.398 1.00 37.90  ? 289 LYS B N   1 
ATOM   6599 C CA  . LYS D 4 220 ? 135.567 146.495 135.230 1.00 37.90  ? 289 LYS B CA  1 
ATOM   6600 C C   . LYS D 4 220 ? 134.884 147.350 134.178 1.00 37.90  ? 289 LYS B C   1 
ATOM   6601 O O   . LYS D 4 220 ? 135.553 147.979 133.358 1.00 37.90  ? 289 LYS B O   1 
ATOM   6602 C CB  . LYS D 4 220 ? 135.954 145.140 134.656 1.00 37.90  ? 289 LYS B CB  1 
ATOM   6603 C CG  . LYS D 4 220 ? 136.771 144.315 135.610 1.00 37.90  ? 289 LYS B CG  1 
ATOM   6604 C CD  . LYS D 4 220 ? 138.088 144.981 135.877 1.00 37.90  ? 289 LYS B CD  1 
ATOM   6605 C CE  . LYS D 4 220 ? 138.937 144.149 136.781 1.00 37.90  ? 289 LYS B CE  1 
ATOM   6606 N NZ  . LYS D 4 220 ? 140.199 144.858 137.081 1.00 37.90  ? 289 LYS B NZ  1 
ATOM   6607 N N   . LEU D 4 221 ? 133.556 147.377 134.174 1.00 36.49  ? 290 LEU B N   1 
ATOM   6608 C CA  . LEU D 4 221 ? 132.848 148.275 133.278 1.00 36.49  ? 290 LEU B CA  1 
ATOM   6609 C C   . LEU D 4 221 ? 132.941 149.716 133.743 1.00 36.49  ? 290 LEU B C   1 
ATOM   6610 O O   . LEU D 4 221 ? 132.903 150.634 132.922 1.00 36.49  ? 290 LEU B O   1 
ATOM   6611 C CB  . LEU D 4 221 ? 131.395 147.858 133.178 1.00 36.49  ? 290 LEU B CB  1 
ATOM   6612 C CG  . LEU D 4 221 ? 131.221 146.504 132.535 1.00 36.49  ? 290 LEU B CG  1 
ATOM   6613 C CD1 . LEU D 4 221 ? 129.783 146.076 132.632 1.00 36.49  ? 290 LEU B CD1 1 
ATOM   6614 C CD2 . LEU D 4 221 ? 131.666 146.580 131.106 1.00 36.49  ? 290 LEU B CD2 1 
ATOM   6615 N N   . ILE D 4 222 ? 133.052 149.936 135.050 1.00 37.02  ? 291 ILE B N   1 
ATOM   6616 C CA  . ILE D 4 222 ? 133.090 151.294 135.566 1.00 37.02  ? 291 ILE B CA  1 
ATOM   6617 C C   . ILE D 4 222 ? 134.515 151.827 135.588 1.00 37.02  ? 291 ILE B C   1 
ATOM   6618 O O   . ILE D 4 222 ? 134.743 153.010 135.320 1.00 37.02  ? 291 ILE B O   1 
ATOM   6619 C CB  . ILE D 4 222 ? 132.409 151.330 136.944 1.00 37.02  ? 291 ILE B CB  1 
ATOM   6620 C CG1 . ILE D 4 222 ? 130.932 151.006 136.789 1.00 37.02  ? 291 ILE B CG1 1 
ATOM   6621 C CG2 . ILE D 4 222 ? 132.502 152.689 137.584 1.00 37.02  ? 291 ILE B CG2 1 
ATOM   6622 C CD1 . ILE D 4 222 ? 130.221 150.809 138.085 1.00 37.02  ? 291 ILE B CD1 1 
ATOM   6623 N N   . ASP D 4 223 ? 135.499 150.972 135.845 1.00 36.90  ? 292 ASP B N   1 
ATOM   6624 C CA  . ASP D 4 223 ? 136.886 151.412 135.791 1.00 36.90  ? 292 ASP B CA  1 
ATOM   6625 C C   . ASP D 4 223 ? 137.326 151.724 134.369 1.00 36.90  ? 292 ASP B C   1 
ATOM   6626 O O   . ASP D 4 223 ? 138.210 152.558 134.163 1.00 36.90  ? 292 ASP B O   1 
ATOM   6627 C CB  . ASP D 4 223 ? 137.795 150.347 136.397 1.00 36.90  ? 292 ASP B CB  1 
ATOM   6628 N N   . ASN D 4 224 ? 136.717 151.079 133.381 1.00 37.54  ? 293 ASN B N   1 
ATOM   6629 C CA  . ASN D 4 224 ? 137.061 151.270 131.981 1.00 37.54  ? 293 ASN B CA  1 
ATOM   6630 C C   . ASN D 4 224 ? 136.112 152.219 131.267 1.00 37.54  ? 293 ASN B C   1 
ATOM   6631 O O   . ASN D 4 224 ? 136.218 152.367 130.048 1.00 37.54  ? 293 ASN B O   1 
ATOM   6632 C CB  . ASN D 4 224 ? 137.090 149.923 131.270 1.00 37.54  ? 293 ASN B CB  1 
ATOM   6633 C CG  . ASN D 4 224 ? 138.238 149.058 131.726 1.00 37.54  ? 293 ASN B CG  1 
ATOM   6634 O OD1 . ASN D 4 224 ? 139.378 149.506 131.787 1.00 37.54  ? 293 ASN B OD1 1 
ATOM   6635 N ND2 . ASN D 4 224 ? 137.937 147.825 132.095 1.00 37.54  ? 293 ASN B ND2 1 
ATOM   6636 N N   . ASN D 4 225 ? 135.182 152.834 132.004 1.00 38.42  ? 294 ASN B N   1 
ATOM   6637 C CA  . ASN D 4 225 ? 134.299 153.905 131.533 1.00 38.42  ? 294 ASN B CA  1 
ATOM   6638 C C   . ASN D 4 225 ? 133.404 153.436 130.400 1.00 38.42  ? 294 ASN B C   1 
ATOM   6639 O O   . ASN D 4 225 ? 133.078 154.196 129.494 1.00 38.42  ? 294 ASN B O   1 
ATOM   6640 C CB  . ASN D 4 225 ? 135.090 155.144 131.110 1.00 38.42  ? 294 ASN B CB  1 
ATOM   6641 C CG  . ASN D 4 225 ? 135.848 155.764 132.250 1.00 38.42  ? 294 ASN B CG  1 
ATOM   6642 O OD1 . ASN D 4 225 ? 135.340 155.868 133.360 1.00 38.42  ? 294 ASN B OD1 1 
ATOM   6643 N ND2 . ASN D 4 225 ? 137.079 156.171 131.987 1.00 38.42  ? 294 ASN B ND2 1 
ATOM   6644 N N   . ILE D 4 226 ? 132.995 152.182 130.452 1.00 36.33  ? 295 ILE B N   1 
ATOM   6645 C CA  . ILE D 4 226 ? 132.302 151.541 129.347 1.00 36.33  ? 295 ILE B CA  1 
ATOM   6646 C C   . ILE D 4 226 ? 130.827 151.439 129.670 1.00 36.33  ? 295 ILE B C   1 
ATOM   6647 O O   . ILE D 4 226 ? 130.443 150.967 130.744 1.00 36.33  ? 295 ILE B O   1 
ATOM   6648 C CB  . ILE D 4 226 ? 132.923 150.172 129.028 1.00 36.33  ? 295 ILE B CB  1 
ATOM   6649 C CG1 . ILE D 4 226 ? 134.233 150.415 128.299 1.00 36.33  ? 295 ILE B CG1 1 
ATOM   6650 C CG2 . ILE D 4 226 ? 132.017 149.308 128.191 1.00 36.33  ? 295 ILE B CG2 1 
ATOM   6651 C CD1 . ILE D 4 226 ? 135.063 149.247 128.159 1.00 36.33  ? 295 ILE B CD1 1 
ATOM   6652 N N   . ASN D 4 227 ? 130.008 151.905 128.740 1.00 35.45  ? 296 ASN B N   1 
ATOM   6653 C CA  . ASN D 4 227 ? 128.568 151.969 128.880 1.00 35.45  ? 296 ASN B CA  1 
ATOM   6654 C C   . ASN D 4 227 ? 127.967 150.798 128.130 1.00 35.45  ? 296 ASN B C   1 
ATOM   6655 O O   . ASN D 4 227 ? 128.202 150.644 126.931 1.00 35.45  ? 296 ASN B O   1 
ATOM   6656 C CB  . ASN D 4 227 ? 128.070 153.281 128.303 1.00 35.45  ? 296 ASN B CB  1 
ATOM   6657 C CG  . ASN D 4 227 ? 128.630 154.467 129.018 1.00 35.45  ? 296 ASN B CG  1 
ATOM   6658 O OD1 . ASN D 4 227 ? 128.653 154.504 130.238 1.00 35.45  ? 296 ASN B OD1 1 
ATOM   6659 N ND2 . ASN D 4 227 ? 129.125 155.429 128.267 1.00 35.45  ? 296 ASN B ND2 1 
ATOM   6660 N N   . VAL D 4 228 ? 127.191 149.989 128.818 1.00 33.10  ? 297 VAL B N   1 
ATOM   6661 C CA  . VAL D 4 228 ? 126.685 148.742 128.266 1.00 33.10  ? 297 VAL B CA  1 
ATOM   6662 C C   . VAL D 4 228 ? 125.218 148.898 127.929 1.00 33.10  ? 297 VAL B C   1 
ATOM   6663 O O   . VAL D 4 228 ? 124.423 149.348 128.752 1.00 33.10  ? 297 VAL B O   1 
ATOM   6664 C CB  . VAL D 4 228 ? 126.914 147.578 129.243 1.00 33.10  ? 297 VAL B CB  1 
ATOM   6665 C CG1 . VAL D 4 228 ? 126.216 146.340 128.776 1.00 33.10  ? 297 VAL B CG1 1 
ATOM   6666 C CG2 . VAL D 4 228 ? 128.388 147.304 129.362 1.00 33.10  ? 297 VAL B CG2 1 
ATOM   6667 N N   . ILE D 4 229 ? 124.865 148.545 126.702 1.00 33.42  ? 298 ILE B N   1 
ATOM   6668 C CA  . ILE D 4 229 ? 123.485 148.473 126.257 1.00 33.42  ? 298 ILE B CA  1 
ATOM   6669 C C   . ILE D 4 229 ? 123.203 147.023 125.905 1.00 33.42  ? 298 ILE B C   1 
ATOM   6670 O O   . ILE D 4 229 ? 123.981 146.405 125.176 1.00 33.42  ? 298 ILE B O   1 
ATOM   6671 C CB  . ILE D 4 229 ? 123.244 149.389 125.051 1.00 33.42  ? 298 ILE B CB  1 
ATOM   6672 C CG1 . ILE D 4 229 ? 123.710 150.803 125.374 1.00 33.42  ? 298 ILE B CG1 1 
ATOM   6673 C CG2 . ILE D 4 229 ? 121.774 149.416 124.712 1.00 33.42  ? 298 ILE B CG2 1 
ATOM   6674 C CD1 . ILE D 4 229 ? 123.829 151.690 124.182 1.00 33.42  ? 298 ILE B CD1 1 
ATOM   6675 N N   . PHE D 4 230 ? 122.121 146.470 126.441 1.00 33.39  ? 299 PHE B N   1 
ATOM   6676 C CA  . PHE D 4 230 ? 121.713 145.108 126.125 1.00 33.39  ? 299 PHE B CA  1 
ATOM   6677 C C   . PHE D 4 230 ? 120.606 145.164 125.087 1.00 33.39  ? 299 PHE B C   1 
ATOM   6678 O O   . PHE D 4 230 ? 119.617 145.872 125.273 1.00 33.39  ? 299 PHE B O   1 
ATOM   6679 C CB  . PHE D 4 230 ? 121.229 144.349 127.359 1.00 33.39  ? 299 PHE B CB  1 
ATOM   6680 C CG  . PHE D 4 230 ? 122.301 144.075 128.373 1.00 33.39  ? 299 PHE B CG  1 
ATOM   6681 C CD1 . PHE D 4 230 ? 123.286 143.148 128.120 1.00 33.39  ? 299 PHE B CD1 1 
ATOM   6682 C CD2 . PHE D 4 230 ? 122.289 144.702 129.598 1.00 33.39  ? 299 PHE B CD2 1 
ATOM   6683 C CE1 . PHE D 4 230 ? 124.254 142.893 129.045 1.00 33.39  ? 299 PHE B CE1 1 
ATOM   6684 C CE2 . PHE D 4 230 ? 123.257 144.435 130.520 1.00 33.39  ? 299 PHE B CE2 1 
ATOM   6685 C CZ  . PHE D 4 230 ? 124.233 143.533 130.242 1.00 33.39  ? 299 PHE B CZ  1 
ATOM   6686 N N   . ALA D 4 231 ? 120.771 144.427 124.004 1.00 35.10  ? 300 ALA B N   1 
ATOM   6687 C CA  . ALA D 4 231 ? 119.786 144.364 122.939 1.00 35.10  ? 300 ALA B CA  1 
ATOM   6688 C C   . ALA D 4 231 ? 119.306 142.924 122.876 1.00 35.10  ? 300 ALA B C   1 
ATOM   6689 O O   . ALA D 4 231 ? 119.911 142.085 122.214 1.00 35.10  ? 300 ALA B O   1 
ATOM   6690 C CB  . ALA D 4 231 ? 120.378 144.817 121.628 1.00 35.10  ? 300 ALA B CB  1 
ATOM   6691 N N   . VAL D 4 232 ? 118.213 142.639 123.571 1.00 37.02  ? 301 VAL B N   1 
ATOM   6692 C CA  . VAL D 4 232 ? 117.763 141.274 123.794 1.00 37.02  ? 301 VAL B CA  1 
ATOM   6693 C C   . VAL D 4 232 ? 116.438 141.089 123.080 1.00 37.02  ? 301 VAL B C   1 
ATOM   6694 O O   . VAL D 4 232 ? 115.548 141.934 123.180 1.00 37.02  ? 301 VAL B O   1 
ATOM   6695 C CB  . VAL D 4 232 ? 117.634 140.964 125.295 1.00 37.02  ? 301 VAL B CB  1 
ATOM   6696 C CG1 . VAL D 4 232 ? 117.344 139.504 125.513 1.00 37.02  ? 301 VAL B CG1 1 
ATOM   6697 C CG2 . VAL D 4 232 ? 118.878 141.365 126.010 1.00 37.02  ? 301 VAL B CG2 1 
ATOM   6698 N N   . GLN D 4 233 ? 116.301 139.975 122.373 1.00 39.30  ? 302 GLN B N   1 
ATOM   6699 C CA  . GLN D 4 233 ? 115.251 139.875 121.378 1.00 39.30  ? 302 GLN B CA  1 
ATOM   6700 C C   . GLN D 4 233 ? 114.018 139.166 121.917 1.00 39.30  ? 302 GLN B C   1 
ATOM   6701 O O   . GLN D 4 233 ? 112.902 139.676 121.792 1.00 39.30  ? 302 GLN B O   1 
ATOM   6702 C CB  . GLN D 4 233 ? 115.790 139.166 120.135 1.00 39.30  ? 302 GLN B CB  1 
ATOM   6703 C CG  . GLN D 4 233 ? 114.967 139.388 118.876 1.00 39.30  ? 302 GLN B CG  1 
ATOM   6704 C CD  . GLN D 4 233 ? 113.880 138.377 118.691 1.00 39.30  ? 302 GLN B CD  1 
ATOM   6705 O OE1 . GLN D 4 233 ? 114.029 137.217 119.058 1.00 39.30  ? 302 GLN B OE1 1 
ATOM   6706 N NE2 . GLN D 4 233 ? 112.762 138.812 118.137 1.00 39.30  ? 302 GLN B NE2 1 
ATOM   6707 N N   . GLY D 4 234 ? 114.196 137.985 122.496 1.00 39.67  ? 303 GLY B N   1 
ATOM   6708 C CA  . GLY D 4 234 ? 113.057 137.149 122.830 1.00 39.67  ? 303 GLY B CA  1 
ATOM   6709 C C   . GLY D 4 234 ? 112.351 137.512 124.116 1.00 39.67  ? 303 GLY B C   1 
ATOM   6710 O O   . GLY D 4 234 ? 112.146 138.690 124.408 1.00 39.67  ? 303 GLY B O   1 
ATOM   6711 N N   . LYS D 4 235 ? 111.964 136.497 124.891 1.00 38.48  ? 304 LYS B N   1 
ATOM   6712 C CA  . LYS D 4 235 ? 111.367 136.725 126.197 1.00 38.48  ? 304 LYS B CA  1 
ATOM   6713 C C   . LYS D 4 235 ? 112.396 136.988 127.278 1.00 38.48  ? 304 LYS B C   1 
ATOM   6714 O O   . LYS D 4 235 ? 112.018 137.335 128.395 1.00 38.48  ? 304 LYS B O   1 
ATOM   6715 C CB  . LYS D 4 235 ? 110.514 135.529 126.609 1.00 38.48  ? 304 LYS B CB  1 
ATOM   6716 N N   . GLN D 4 236 ? 113.682 136.831 126.984 1.00 39.24  ? 305 GLN B N   1 
ATOM   6717 C CA  . GLN D 4 236 ? 114.670 137.065 128.023 1.00 39.24  ? 305 GLN B CA  1 
ATOM   6718 C C   . GLN D 4 236 ? 115.126 138.504 128.086 1.00 39.24  ? 305 GLN B C   1 
ATOM   6719 O O   . GLN D 4 236 ? 116.194 138.761 128.645 1.00 39.24  ? 305 GLN B O   1 
ATOM   6720 C CB  . GLN D 4 236 ? 115.892 136.166 127.838 1.00 39.24  ? 305 GLN B CB  1 
ATOM   6721 C CG  . GLN D 4 236 ? 115.597 134.685 127.844 1.00 39.24  ? 305 GLN B CG  1 
ATOM   6722 C CD  . GLN D 4 236 ? 114.729 134.261 129.004 1.00 39.24  ? 305 GLN B CD  1 
ATOM   6723 O OE1 . GLN D 4 236 ? 113.611 133.806 128.812 1.00 39.24  ? 305 GLN B OE1 1 
ATOM   6724 N NE2 . GLN D 4 236 ? 115.216 134.450 130.211 1.00 39.24  ? 305 GLN B NE2 1 
ATOM   6725 N N   . PHE D 4 237 ? 114.382 139.438 127.497 1.00 37.25  ? 306 PHE B N   1 
ATOM   6726 C CA  . PHE D 4 237 ? 114.624 140.850 127.762 1.00 37.25  ? 306 PHE B CA  1 
ATOM   6727 C C   . PHE D 4 237 ? 114.366 141.179 129.219 1.00 37.25  ? 306 PHE B C   1 
ATOM   6728 O O   . PHE D 4 237 ? 115.078 141.986 129.822 1.00 37.25  ? 306 PHE B O   1 
ATOM   6729 C CB  . PHE D 4 237 ? 113.747 141.716 126.864 1.00 37.25  ? 306 PHE B CB  1 
ATOM   6730 C CG  . PHE D 4 237 ? 113.684 143.153 127.293 1.00 37.25  ? 306 PHE B CG  1 
ATOM   6731 C CD1 . PHE D 4 237 ? 114.779 143.978 127.161 1.00 37.25  ? 306 PHE B CD1 1 
ATOM   6732 C CD2 . PHE D 4 237 ? 112.516 143.673 127.821 1.00 37.25  ? 306 PHE B CD2 1 
ATOM   6733 C CE1 . PHE D 4 237 ? 114.711 145.278 127.558 1.00 37.25  ? 306 PHE B CE1 1 
ATOM   6734 C CE2 . PHE D 4 237 ? 112.447 144.968 128.216 1.00 37.25  ? 306 PHE B CE2 1 
ATOM   6735 C CZ  . PHE D 4 237 ? 113.550 145.775 128.082 1.00 37.25  ? 306 PHE B CZ  1 
ATOM   6736 N N   . HIS D 4 238 ? 113.362 140.533 129.807 1.00 36.61  ? 307 HIS B N   1 
ATOM   6737 C CA  . HIS D 4 238 ? 112.983 140.783 131.186 1.00 36.61  ? 307 HIS B CA  1 
ATOM   6738 C C   . HIS D 4 238 ? 114.021 140.279 132.174 1.00 36.61  ? 307 HIS B C   1 
ATOM   6739 O O   . HIS D 4 238 ? 114.027 140.722 133.320 1.00 36.61  ? 307 HIS B O   1 
ATOM   6740 C CB  . HIS D 4 238 ? 111.644 140.118 131.449 1.00 36.61  ? 307 HIS B CB  1 
ATOM   6741 C CG  . HIS D 4 238 ? 110.570 140.545 130.504 1.00 36.61  ? 307 HIS B CG  1 
ATOM   6742 N ND1 . HIS D 4 238 ? 109.905 141.742 130.619 1.00 36.61  ? 307 HIS B ND1 1 
ATOM   6743 C CD2 . HIS D 4 238 ? 110.061 139.937 129.412 1.00 36.61  ? 307 HIS B CD2 1 
ATOM   6744 C CE1 . HIS D 4 238 ? 109.022 141.848 129.646 1.00 36.61  ? 307 HIS B CE1 1 
ATOM   6745 N NE2 . HIS D 4 238 ? 109.098 140.766 128.898 1.00 36.61  ? 307 HIS B NE2 1 
ATOM   6746 N N   . TRP D 4 239 ? 114.891 139.361 131.764 1.00 36.11  ? 308 TRP B N   1 
ATOM   6747 C CA  . TRP D 4 239 ? 115.955 138.913 132.648 1.00 36.11  ? 308 TRP B CA  1 
ATOM   6748 C C   . TRP D 4 239 ? 117.008 139.994 132.806 1.00 36.11  ? 308 TRP B C   1 
ATOM   6749 O O   . TRP D 4 239 ? 117.394 140.342 133.925 1.00 36.11  ? 308 TRP B O   1 
ATOM   6750 C CB  . TRP D 4 239 ? 116.597 137.643 132.102 1.00 36.11  ? 308 TRP B CB  1 
ATOM   6751 C CG  . TRP D 4 239 ? 117.558 136.995 133.053 1.00 36.11  ? 308 TRP B CG  1 
ATOM   6752 C CD1 . TRP D 4 239 ? 117.244 136.310 134.175 1.00 36.11  ? 308 TRP B CD1 1 
ATOM   6753 C CD2 . TRP D 4 239 ? 118.987 137.010 132.982 1.00 36.11  ? 308 TRP B CD2 1 
ATOM   6754 N NE1 . TRP D 4 239 ? 118.378 135.873 134.795 1.00 36.11  ? 308 TRP B NE1 1 
ATOM   6755 C CE2 . TRP D 4 239 ? 119.463 136.293 134.080 1.00 36.11  ? 308 TRP B CE2 1 
ATOM   6756 C CE3 . TRP D 4 239 ? 119.905 137.543 132.086 1.00 36.11  ? 308 TRP B CE3 1 
ATOM   6757 C CZ2 . TRP D 4 239 ? 120.810 136.097 134.308 1.00 36.11  ? 308 TRP B CZ2 1 
ATOM   6758 C CZ3 . TRP D 4 239 ? 121.241 137.350 132.320 1.00 36.11  ? 308 TRP B CZ3 1 
ATOM   6759 C CH2 . TRP D 4 239 ? 121.681 136.633 133.417 1.00 36.11  ? 308 TRP B CH2 1 
ATOM   6760 N N   . TYR D 4 240 ? 117.503 140.515 131.686 1.00 37.68  ? 309 TYR B N   1 
ATOM   6761 C CA  . TYR D 4 240 ? 118.484 141.585 131.705 1.00 37.68  ? 309 TYR B CA  1 
ATOM   6762 C C   . TYR D 4 240 ? 117.901 142.883 132.223 1.00 37.68  ? 309 TYR B C   1 
ATOM   6763 O O   . TYR D 4 240 ? 118.645 143.709 132.757 1.00 37.68  ? 309 TYR B O   1 
ATOM   6764 C CB  . TYR D 4 240 ? 119.028 141.812 130.303 1.00 37.68  ? 309 TYR B CB  1 
ATOM   6765 C CG  . TYR D 4 240 ? 119.921 140.724 129.788 1.00 37.68  ? 309 TYR B CG  1 
ATOM   6766 C CD1 . TYR D 4 240 ? 121.278 140.748 130.039 1.00 37.68  ? 309 TYR B CD1 1 
ATOM   6767 C CD2 . TYR D 4 240 ? 119.404 139.661 129.073 1.00 37.68  ? 309 TYR B CD2 1 
ATOM   6768 C CE1 . TYR D 4 240 ? 122.104 139.767 129.566 1.00 37.68  ? 309 TYR B CE1 1 
ATOM   6769 C CE2 . TYR D 4 240 ? 120.221 138.670 128.595 1.00 37.68  ? 309 TYR B CE2 1 
ATOM   6770 C CZ  . TYR D 4 240 ? 121.571 138.730 128.849 1.00 37.68  ? 309 TYR B CZ  1 
ATOM   6771 O OH  . TYR D 4 240 ? 122.397 137.740 128.383 1.00 37.68  ? 309 TYR B OH  1 
ATOM   6772 N N   . LYS D 4 241 ? 116.591 143.084 132.051 1.00 38.16  ? 310 LYS B N   1 
ATOM   6773 C CA  . LYS D 4 241 ? 115.899 144.241 132.598 1.00 38.16  ? 310 LYS B CA  1 
ATOM   6774 C C   . LYS D 4 241 ? 115.909 144.242 134.117 1.00 38.16  ? 310 LYS B C   1 
ATOM   6775 O O   . LYS D 4 241 ? 115.958 145.312 134.727 1.00 38.16  ? 310 LYS B O   1 
ATOM   6776 C CB  . LYS D 4 241 ? 114.468 144.261 132.073 1.00 38.16  ? 310 LYS B CB  1 
ATOM   6777 C CG  . LYS D 4 241 ? 113.639 145.439 132.486 1.00 38.16  ? 310 LYS B CG  1 
ATOM   6778 C CD  . LYS D 4 241 ? 112.256 145.339 131.907 1.00 38.16  ? 310 LYS B CD  1 
ATOM   6779 C CE  . LYS D 4 241 ? 111.424 146.516 132.331 1.00 38.16  ? 310 LYS B CE  1 
ATOM   6780 N NZ  . LYS D 4 241 ? 111.159 146.456 133.789 1.00 38.16  ? 310 LYS B NZ  1 
ATOM   6781 N N   . ASP D 4 242 ? 115.914 143.075 134.739 1.00 37.39  ? 311 ASP B N   1 
ATOM   6782 C CA  . ASP D 4 242 ? 115.904 142.992 136.183 1.00 37.39  ? 311 ASP B CA  1 
ATOM   6783 C C   . ASP D 4 242 ? 117.294 142.939 136.793 1.00 37.39  ? 311 ASP B C   1 
ATOM   6784 O O   . ASP D 4 242 ? 117.409 143.001 138.016 1.00 37.39  ? 311 ASP B O   1 
ATOM   6785 C CB  . ASP D 4 242 ? 115.106 141.772 136.618 1.00 37.39  ? 311 ASP B CB  1 
ATOM   6786 C CG  . ASP D 4 242 ? 113.659 141.846 136.187 1.00 37.39  ? 311 ASP B CG  1 
ATOM   6787 O OD1 . ASP D 4 242 ? 113.146 142.963 136.000 1.00 37.39  ? 311 ASP B OD1 1 
ATOM   6788 O OD2 . ASP D 4 242 ? 113.027 140.783 136.040 1.00 37.39  ? 311 ASP B OD2 1 
ATOM   6789 N N   . LEU D 4 243 ? 118.347 142.815 135.993 1.00 37.90  ? 312 LEU B N   1 
ATOM   6790 C CA  . LEU D 4 243 ? 119.705 142.887 136.513 1.00 37.90  ? 312 LEU B CA  1 
ATOM   6791 C C   . LEU D 4 243 ? 120.276 144.286 136.469 1.00 37.90  ? 312 LEU B C   1 
ATOM   6792 O O   . LEU D 4 243 ? 121.364 144.507 137.006 1.00 37.90  ? 312 LEU B O   1 
ATOM   6793 C CB  . LEU D 4 243 ? 120.660 141.995 135.724 1.00 37.90  ? 312 LEU B CB  1 
ATOM   6794 C CG  . LEU D 4 243 ? 120.600 140.476 135.677 1.00 37.90  ? 312 LEU B CG  1 
ATOM   6795 C CD1 . LEU D 4 243 ? 121.702 140.028 134.748 1.00 37.90  ? 312 LEU B CD1 1 
ATOM   6796 C CD2 . LEU D 4 243 ? 120.772 139.863 137.051 1.00 37.90  ? 312 LEU B CD2 1 
ATOM   6797 N N   . LEU D 4 244 ? 119.597 145.203 135.791 1.00 37.30  ? 313 LEU B N   1 
ATOM   6798 C CA  . LEU D 4 244 ? 120.025 146.597 135.728 1.00 37.30  ? 313 LEU B CA  1 
ATOM   6799 C C   . LEU D 4 244 ? 120.216 147.281 137.082 1.00 37.30  ? 313 LEU B C   1 
ATOM   6800 O O   . LEU D 4 244 ? 121.106 148.142 137.166 1.00 37.30  ? 313 LEU B O   1 
ATOM   6801 C CB  . LEU D 4 244 ? 119.024 147.394 134.878 1.00 37.30  ? 313 LEU B CB  1 
ATOM   6802 C CG  . LEU D 4 244 ? 118.723 146.946 133.451 1.00 37.30  ? 313 LEU B CG  1 
ATOM   6803 C CD1 . LEU D 4 244 ? 117.658 147.823 132.844 1.00 37.30  ? 313 LEU B CD1 1 
ATOM   6804 C CD2 . LEU D 4 244 ? 119.953 146.937 132.591 1.00 37.30  ? 313 LEU B CD2 1 
ATOM   6805 N N   . PRO D 4 245 ? 119.449 147.003 138.153 1.00 36.85  ? 314 PRO B N   1 
ATOM   6806 C CA  . PRO D 4 245 ? 119.837 147.583 139.443 1.00 36.85  ? 314 PRO B CA  1 
ATOM   6807 C C   . PRO D 4 245 ? 121.112 147.016 140.021 1.00 36.85  ? 314 PRO B C   1 
ATOM   6808 O O   . PRO D 4 245 ? 121.737 147.675 140.856 1.00 36.85  ? 314 PRO B O   1 
ATOM   6809 C CB  . PRO D 4 245 ? 118.638 147.271 140.335 1.00 36.85  ? 314 PRO B CB  1 
ATOM   6810 C CG  . PRO D 4 245 ? 117.538 147.168 139.437 1.00 36.85  ? 314 PRO B CG  1 
ATOM   6811 C CD  . PRO D 4 245 ? 118.056 146.520 138.238 1.00 36.85  ? 314 PRO B CD  1 
ATOM   6812 N N   . LEU D 4 246 ? 121.520 145.818 139.614 1.00 37.16  ? 315 LEU B N   1 
ATOM   6813 C CA  . LEU D 4 246 ? 122.758 145.242 140.125 1.00 37.16  ? 315 LEU B CA  1 
ATOM   6814 C C   . LEU D 4 246 ? 123.967 145.701 139.330 1.00 37.16  ? 315 LEU B C   1 
ATOM   6815 O O   . LEU D 4 246 ? 125.095 145.630 139.825 1.00 37.16  ? 315 LEU B O   1 
ATOM   6816 C CB  . LEU D 4 246 ? 122.669 143.720 140.112 1.00 37.16  ? 315 LEU B CB  1 
ATOM   6817 C CG  . LEU D 4 246 ? 121.609 143.142 141.044 1.00 37.16  ? 315 LEU B CG  1 
ATOM   6818 C CD1 . LEU D 4 246 ? 121.515 141.643 140.894 1.00 37.16  ? 315 LEU B CD1 1 
ATOM   6819 C CD2 . LEU D 4 246 ? 121.903 143.518 142.477 1.00 37.16  ? 315 LEU B CD2 1 
ATOM   6820 N N   . LEU D 4 247 ? 123.745 146.171 138.106 1.00 36.35  ? 316 LEU B N   1 
ATOM   6821 C CA  . LEU D 4 247 ? 124.777 146.632 137.184 1.00 36.35  ? 316 LEU B CA  1 
ATOM   6822 C C   . LEU D 4 247 ? 124.544 148.113 136.946 1.00 36.35  ? 316 LEU B C   1 
ATOM   6823 O O   . LEU D 4 247 ? 123.763 148.482 136.060 1.00 36.35  ? 316 LEU B O   1 
ATOM   6824 C CB  . LEU D 4 247 ? 124.701 145.857 135.866 1.00 36.35  ? 316 LEU B CB  1 
ATOM   6825 C CG  . LEU D 4 247 ? 124.968 144.357 135.865 1.00 36.35  ? 316 LEU B CG  1 
ATOM   6826 C CD1 . LEU D 4 247 ? 124.556 143.768 134.553 1.00 36.35  ? 316 LEU B CD1 1 
ATOM   6827 C CD2 . LEU D 4 247 ? 126.434 144.118 136.091 1.00 36.35  ? 316 LEU B CD2 1 
ATOM   6828 N N   . PRO D 4 248 ? 125.166 148.998 137.716 1.00 36.93  ? 317 PRO B N   1 
ATOM   6829 C CA  . PRO D 4 248 ? 124.938 150.433 137.524 1.00 36.93  ? 317 PRO B CA  1 
ATOM   6830 C C   . PRO D 4 248 ? 125.573 150.945 136.244 1.00 36.93  ? 317 PRO B C   1 
ATOM   6831 O O   . PRO D 4 248 ? 126.734 150.661 135.949 1.00 36.93  ? 317 PRO B O   1 
ATOM   6832 C CB  . PRO D 4 248 ? 125.600 151.059 138.751 1.00 36.93  ? 317 PRO B CB  1 
ATOM   6833 C CG  . PRO D 4 248 ? 125.652 149.971 139.739 1.00 36.93  ? 317 PRO B CG  1 
ATOM   6834 C CD  . PRO D 4 248 ? 125.890 148.730 138.961 1.00 36.93  ? 317 PRO B CD  1 
ATOM   6835 N N   . GLY D 4 249 ? 124.797 151.706 135.482 1.00 34.44  ? 318 GLY B N   1 
ATOM   6836 C CA  . GLY D 4 249 ? 125.275 152.252 134.233 1.00 34.44  ? 318 GLY B CA  1 
ATOM   6837 C C   . GLY D 4 249 ? 124.950 151.433 133.011 1.00 34.44  ? 318 GLY B C   1 
ATOM   6838 O O   . GLY D 4 249 ? 125.577 151.633 131.967 1.00 34.44  ? 318 GLY B O   1 
ATOM   6839 N N   . THR D 4 250 ? 123.996 150.516 133.102 1.00 33.68  ? 319 THR B N   1 
ATOM   6840 C CA  . THR D 4 250 ? 123.609 149.665 131.993 1.00 33.68  ? 319 THR B CA  1 
ATOM   6841 C C   . THR D 4 250 ? 122.183 149.970 131.587 1.00 33.68  ? 319 THR B C   1 
ATOM   6842 O O   . THR D 4 250 ? 121.321 150.204 132.433 1.00 33.68  ? 319 THR B O   1 
ATOM   6843 C CB  . THR D 4 250 ? 123.732 148.199 132.353 1.00 33.68  ? 319 THR B CB  1 
ATOM   6844 O OG1 . THR D 4 250 ? 122.947 147.939 133.514 1.00 33.68  ? 319 THR B OG1 1 
ATOM   6845 C CG2 . THR D 4 250 ? 125.166 147.839 132.635 1.00 33.68  ? 319 THR B CG2 1 
ATOM   6846 N N   . ILE D 4 251 ? 121.954 149.980 130.288 1.00 34.29  ? 320 ILE B N   1 
ATOM   6847 C CA  . ILE D 4 251 ? 120.653 150.230 129.696 1.00 34.29  ? 320 ILE B CA  1 
ATOM   6848 C C   . ILE D 4 251 ? 120.252 148.951 128.983 1.00 34.29  ? 320 ILE B C   1 
ATOM   6849 O O   . ILE D 4 251 ? 121.105 148.222 128.481 1.00 34.29  ? 320 ILE B O   1 
ATOM   6850 C CB  . ILE D 4 251 ? 120.739 151.434 128.736 1.00 34.29  ? 320 ILE B CB  1 
ATOM   6851 C CG1 . ILE D 4 251 ? 121.333 152.629 129.466 1.00 34.29  ? 320 ILE B CG1 1 
ATOM   6852 C CG2 . ILE D 4 251 ? 119.377 151.847 128.222 1.00 34.29  ? 320 ILE B CG2 1 
ATOM   6853 C CD1 . ILE D 4 251 ? 121.770 153.719 128.570 1.00 34.29  ? 320 ILE B CD1 1 
ATOM   6854 N N   . ALA D 4 252 ? 118.968 148.642 128.980 1.00 33.64  ? 321 ALA B N   1 
ATOM   6855 C CA  . ALA D 4 252 ? 118.498 147.433 128.332 1.00 33.64  ? 321 ALA B CA  1 
ATOM   6856 C C   . ALA D 4 252 ? 117.411 147.778 127.339 1.00 33.64  ? 321 ALA B C   1 
ATOM   6857 O O   . ALA D 4 252 ? 116.450 148.468 127.675 1.00 33.64  ? 321 ALA B O   1 
ATOM   6858 C CB  . ALA D 4 252 ? 117.967 146.428 129.340 1.00 33.64  ? 321 ALA B CB  1 
ATOM   6859 N N   . GLY D 4 253 ? 117.562 147.293 126.121 1.00 36.65  ? 322 GLY B N   1 
ATOM   6860 C CA  . GLY D 4 253 ? 116.595 147.563 125.078 1.00 36.65  ? 322 GLY B CA  1 
ATOM   6861 C C   . GLY D 4 253 ? 116.124 146.273 124.452 1.00 36.65  ? 322 GLY B C   1 
ATOM   6862 O O   . GLY D 4 253 ? 116.887 145.324 124.289 1.00 36.65  ? 322 GLY B O   1 
ATOM   6863 N N   . GLU D 4 254 ? 114.851 146.243 124.107 1.00 37.49  ? 323 GLU B N   1 
ATOM   6864 C CA  . GLU D 4 254 ? 114.241 145.043 123.574 1.00 37.49  ? 323 GLU B CA  1 
ATOM   6865 C C   . GLU D 4 254 ? 114.200 145.126 122.064 1.00 37.49  ? 323 GLU B C   1 
ATOM   6866 O O   . GLU D 4 254 ? 113.567 146.027 121.509 1.00 37.49  ? 323 GLU B O   1 
ATOM   6867 C CB  . GLU D 4 254 ? 112.836 144.850 124.119 1.00 37.49  ? 323 GLU B CB  1 
ATOM   6868 C CG  . GLU D 4 254 ? 112.181 143.603 123.593 1.00 37.49  ? 323 GLU B CG  1 
ATOM   6869 C CD  . GLU D 4 254 ? 110.857 143.332 124.246 1.00 37.49  ? 323 GLU B CD  1 
ATOM   6870 O OE1 . GLU D 4 254 ? 110.464 144.111 125.135 1.00 37.49  ? 323 GLU B OE1 1 
ATOM   6871 O OE2 . GLU D 4 254 ? 110.204 142.341 123.869 1.00 37.49  ? 323 GLU B OE2 1 
ATOM   6872 N N   . ILE D 4 255 ? 114.869 144.192 121.407 1.00 38.83  ? 324 ILE B N   1 
ATOM   6873 C CA  . ILE D 4 255 ? 114.729 144.026 119.971 1.00 38.83  ? 324 ILE B CA  1 
ATOM   6874 C C   . ILE D 4 255 ? 113.335 143.496 119.707 1.00 38.83  ? 324 ILE B C   1 
ATOM   6875 O O   . ILE D 4 255 ? 112.878 142.573 120.384 1.00 38.83  ? 324 ILE B O   1 
ATOM   6876 C CB  . ILE D 4 255 ? 115.800 143.073 119.429 1.00 38.83  ? 324 ILE B CB  1 
ATOM   6877 C CG1 . ILE D 4 255 ? 117.189 143.612 119.716 1.00 38.83  ? 324 ILE B CG1 1 
ATOM   6878 C CG2 . ILE D 4 255 ? 115.674 142.910 117.955 1.00 38.83  ? 324 ILE B CG2 1 
ATOM   6879 C CD1 . ILE D 4 255 ? 118.280 142.646 119.351 1.00 38.83  ? 324 ILE B CD1 1 
ATOM   6880 N N   . GLU D 4 256 ? 112.653 144.068 118.722 1.00 42.66  ? 325 GLU B N   1 
ATOM   6881 C CA  . GLU D 4 256 ? 111.294 143.670 118.403 1.00 42.66  ? 325 GLU B CA  1 
ATOM   6882 C C   . GLU D 4 256 ? 111.291 142.348 117.642 1.00 42.66  ? 325 GLU B C   1 
ATOM   6883 O O   . GLU D 4 256 ? 112.291 141.631 117.581 1.00 42.66  ? 325 GLU B O   1 
ATOM   6884 C CB  . GLU D 4 256 ? 110.596 144.760 117.602 1.00 42.66  ? 325 GLU B CB  1 
ATOM   6885 N N   . SER D 4 257 ? 110.139 142.011 117.064 1.00 46.94  ? 326 SER B N   1 
ATOM   6886 C CA  . SER D 4 257 ? 109.968 140.700 116.446 1.00 46.94  ? 326 SER B CA  1 
ATOM   6887 C C   . SER D 4 257 ? 110.806 140.569 115.183 1.00 46.94  ? 326 SER B C   1 
ATOM   6888 O O   . SER D 4 257 ? 111.611 139.642 115.049 1.00 46.94  ? 326 SER B O   1 
ATOM   6889 C CB  . SER D 4 257 ? 108.495 140.461 116.130 1.00 46.94  ? 326 SER B CB  1 
ATOM   6890 O OG  . SER D 4 257 ? 108.052 141.351 115.123 1.00 46.94  ? 326 SER B OG  1 
ATOM   6891 N N   . LYS D 4 258 ? 110.640 141.495 114.250 1.00 47.76  ? 327 LYS B N   1 
ATOM   6892 C CA  . LYS D 4 258 ? 111.372 141.458 112.996 1.00 47.76  ? 327 LYS B CA  1 
ATOM   6893 C C   . LYS D 4 258 ? 112.676 142.226 113.059 1.00 47.76  ? 327 LYS B C   1 
ATOM   6894 O O   . LYS D 4 258 ? 113.256 142.500 112.005 1.00 47.76  ? 327 LYS B O   1 
ATOM   6895 C CB  . LYS D 4 258 ? 110.505 142.007 111.866 1.00 47.76  ? 327 LYS B CB  1 
ATOM   6896 N N   . ALA D 4 259 ? 113.133 142.571 114.268 1.00 46.50  ? 328 ALA B N   1 
ATOM   6897 C CA  . ALA D 4 259 ? 114.341 143.367 114.525 1.00 46.50  ? 328 ALA B CA  1 
ATOM   6898 C C   . ALA D 4 259 ? 114.306 144.703 113.798 1.00 46.50  ? 328 ALA B C   1 
ATOM   6899 O O   . ALA D 4 259 ? 115.331 145.195 113.322 1.00 46.50  ? 328 ALA B O   1 
ATOM   6900 C CB  . ALA D 4 259 ? 115.619 142.597 114.177 1.00 46.50  ? 328 ALA B CB  1 
ATOM   6901 N N   . ALA D 4 260 ? 113.121 145.307 113.720 1.00 46.25  ? 329 ALA B N   1 
ATOM   6902 C CA  . ALA D 4 260 ? 112.968 146.539 112.965 1.00 46.25  ? 329 ALA B CA  1 
ATOM   6903 C C   . ALA D 4 260 ? 113.482 147.750 113.723 1.00 46.25  ? 329 ALA B C   1 
ATOM   6904 O O   . ALA D 4 260 ? 113.598 148.827 113.135 1.00 46.25  ? 329 ALA B O   1 
ATOM   6905 C CB  . ALA D 4 260 ? 111.504 146.742 112.590 1.00 46.25  ? 329 ALA B CB  1 
ATOM   6906 N N   . ASN D 4 261 ? 113.794 147.605 115.001 1.00 44.64  ? 330 ASN B N   1 
ATOM   6907 C CA  . ASN D 4 261 ? 114.200 148.722 115.839 1.00 44.64  ? 330 ASN B CA  1 
ATOM   6908 C C   . ASN D 4 261 ? 115.606 148.554 116.402 1.00 44.64  ? 330 ASN B C   1 
ATOM   6909 O O   . ASN D 4 261 ? 115.861 148.886 117.555 1.00 44.64  ? 330 ASN B O   1 
ATOM   6910 C CB  . ASN D 4 261 ? 113.195 148.929 116.965 1.00 44.64  ? 330 ASN B CB  1 
ATOM   6911 C CG  . ASN D 4 261 ? 112.940 147.670 117.765 1.00 44.64  ? 330 ASN B CG  1 
ATOM   6912 O OD1 . ASN D 4 261 ? 113.545 146.630 117.529 1.00 44.64  ? 330 ASN B OD1 1 
ATOM   6913 N ND2 . ASN D 4 261 ? 112.031 147.761 118.722 1.00 44.64  ? 330 ASN B ND2 1 
ATOM   6914 N N   . LEU D 4 262 ? 116.533 148.031 115.606 1.00 43.91  ? 331 LEU B N   1 
ATOM   6915 C CA  . LEU D 4 262 ? 117.914 147.981 116.065 1.00 43.91  ? 331 LEU B CA  1 
ATOM   6916 C C   . LEU D 4 262 ? 118.587 149.334 115.972 1.00 43.91  ? 331 LEU B C   1 
ATOM   6917 O O   . LEU D 4 262 ? 119.397 149.689 116.832 1.00 43.91  ? 331 LEU B O   1 
ATOM   6918 C CB  . LEU D 4 262 ? 118.717 146.959 115.273 1.00 43.91  ? 331 LEU B CB  1 
ATOM   6919 C CG  . LEU D 4 262 ? 118.616 145.528 115.753 1.00 43.91  ? 331 LEU B CG  1 
ATOM   6920 C CD1 . LEU D 4 262 ? 119.275 144.639 114.749 1.00 43.91  ? 331 LEU B CD1 1 
ATOM   6921 C CD2 . LEU D 4 262 ? 119.337 145.448 117.074 1.00 43.91  ? 331 LEU B CD2 1 
ATOM   6922 N N   . ASN D 4 263 ? 118.294 150.087 114.925 1.00 44.96  ? 332 ASN B N   1 
ATOM   6923 C CA  . ASN D 4 263 ? 118.918 151.390 114.800 1.00 44.96  ? 332 ASN B CA  1 
ATOM   6924 C C   . ASN D 4 263 ? 118.275 152.386 115.744 1.00 44.96  ? 332 ASN B C   1 
ATOM   6925 O O   . ASN D 4 263 ? 118.937 153.322 116.194 1.00 44.96  ? 332 ASN B O   1 
ATOM   6926 C CB  . ASN D 4 263 ? 118.838 151.852 113.348 1.00 44.96  ? 332 ASN B CB  1 
ATOM   6927 C CG  . ASN D 4 263 ? 119.611 150.945 112.420 1.00 44.96  ? 332 ASN B CG  1 
ATOM   6928 O OD1 . ASN D 4 263 ? 120.719 150.529 112.730 1.00 44.96  ? 332 ASN B OD1 1 
ATOM   6929 N ND2 . ASN D 4 263 ? 119.012 150.603 111.293 1.00 44.96  ? 332 ASN B ND2 1 
ATOM   6930 N N   . ASN D 4 264 ? 117.002 152.173 116.077 1.00 43.89  ? 333 ASN B N   1 
ATOM   6931 C CA  . ASN D 4 264 ? 116.335 152.993 117.076 1.00 43.89  ? 333 ASN B CA  1 
ATOM   6932 C C   . ASN D 4 264 ? 116.806 152.655 118.476 1.00 43.89  ? 333 ASN B C   1 
ATOM   6933 O O   . ASN D 4 264 ? 116.701 153.487 119.376 1.00 43.89  ? 333 ASN B O   1 
ATOM   6934 C CB  . ASN D 4 264 ? 114.829 152.793 117.001 1.00 43.89  ? 333 ASN B CB  1 
ATOM   6935 C CG  . ASN D 4 264 ? 114.253 153.257 115.703 1.00 43.89  ? 333 ASN B CG  1 
ATOM   6936 O OD1 . ASN D 4 264 ? 114.650 154.286 115.169 1.00 43.89  ? 333 ASN B OD1 1 
ATOM   6937 N ND2 . ASN D 4 264 ? 113.303 152.501 115.180 1.00 43.89  ? 333 ASN B ND2 1 
ATOM   6938 N N   . LEU D 4 265 ? 117.310 151.442 118.685 1.00 40.89  ? 334 LEU B N   1 
ATOM   6939 C CA  . LEU D 4 265 ? 117.698 151.029 120.025 1.00 40.89  ? 334 LEU B CA  1 
ATOM   6940 C C   . LEU D 4 265 ? 118.988 151.708 120.438 1.00 40.89  ? 334 LEU B C   1 
ATOM   6941 O O   . LEU D 4 265 ? 119.184 152.025 121.610 1.00 40.89  ? 334 LEU B O   1 
ATOM   6942 C CB  . LEU D 4 265 ? 117.834 149.506 120.079 1.00 40.89  ? 334 LEU B CB  1 
ATOM   6943 C CG  . LEU D 4 265 ? 117.824 148.743 121.405 1.00 40.89  ? 334 LEU B CG  1 
ATOM   6944 C CD1 . LEU D 4 265 ? 117.221 147.384 121.162 1.00 40.89  ? 334 LEU B CD1 1 
ATOM   6945 C CD2 . LEU D 4 265 ? 119.206 148.582 122.005 1.00 40.89  ? 334 LEU B CD2 1 
ATOM   6946 N N   . VAL D 4 266 ? 119.885 151.934 119.487 1.00 41.95  ? 335 VAL B N   1 
ATOM   6947 C CA  . VAL D 4 266 ? 121.143 152.584 119.816 1.00 41.95  ? 335 VAL B CA  1 
ATOM   6948 C C   . VAL D 4 266 ? 120.931 154.082 119.972 1.00 41.95  ? 335 VAL B C   1 
ATOM   6949 O O   . VAL D 4 266 ? 121.566 154.732 120.810 1.00 41.95  ? 335 VAL B O   1 
ATOM   6950 C CB  . VAL D 4 266 ? 122.197 152.249 118.745 1.00 41.95  ? 335 VAL B CB  1 
ATOM   6951 C CG1 . VAL D 4 266 ? 123.526 152.921 119.032 1.00 41.95  ? 335 VAL B CG1 1 
ATOM   6952 C CG2 . VAL D 4 266 ? 122.388 150.758 118.665 1.00 41.95  ? 335 VAL B CG2 1 
ATOM   6953 N N   . VAL D 4 267 ? 120.006 154.644 119.196 1.00 41.59  ? 336 VAL B N   1 
ATOM   6954 C CA  . VAL D 4 267 ? 119.725 156.074 119.269 1.00 41.59  ? 336 VAL B CA  1 
ATOM   6955 C C   . VAL D 4 267 ? 119.048 156.418 120.587 1.00 41.59  ? 336 VAL B C   1 
ATOM   6956 O O   . VAL D 4 267 ? 119.437 157.367 121.273 1.00 41.59  ? 336 VAL B O   1 
ATOM   6957 C CB  . VAL D 4 267 ? 118.877 156.505 118.060 1.00 41.59  ? 336 VAL B CB  1 
ATOM   6958 C CG1 . VAL D 4 267 ? 118.371 157.912 118.229 1.00 41.59  ? 336 VAL B CG1 1 
ATOM   6959 C CG2 . VAL D 4 267 ? 119.712 156.431 116.811 1.00 41.59  ? 336 VAL B CG2 1 
ATOM   6960 N N   . GLU D 4 268 ? 118.050 155.627 120.978 1.00 42.17  ? 337 GLU B N   1 
ATOM   6961 C CA  . GLU D 4 268 ? 117.280 155.938 122.175 1.00 42.17  ? 337 GLU B CA  1 
ATOM   6962 C C   . GLU D 4 268 ? 118.060 155.645 123.445 1.00 42.17  ? 337 GLU B C   1 
ATOM   6963 O O   . GLU D 4 268 ? 117.865 156.313 124.463 1.00 42.17  ? 337 GLU B O   1 
ATOM   6964 C CB  . GLU D 4 268 ? 115.977 155.158 122.162 1.00 42.17  ? 337 GLU B CB  1 
ATOM   6965 C CG  . GLU D 4 268 ? 115.017 155.634 121.112 1.00 42.17  ? 337 GLU B CG  1 
ATOM   6966 C CD  . GLU D 4 268 ? 113.791 154.774 121.031 1.00 42.17  ? 337 GLU B CD  1 
ATOM   6967 O OE1 . GLU D 4 268 ? 113.751 153.735 121.717 1.00 42.17  ? 337 GLU B OE1 1 
ATOM   6968 O OE2 . GLU D 4 268 ? 112.866 155.130 120.275 1.00 42.17  ? 337 GLU B OE2 1 
ATOM   6969 N N   . ALA D 4 269 ? 118.942 154.651 123.414 1.00 38.86  ? 338 ALA B N   1 
ATOM   6970 C CA  . ALA D 4 269 ? 119.726 154.349 124.601 1.00 38.86  ? 338 ALA B CA  1 
ATOM   6971 C C   . ALA D 4 269 ? 120.881 155.312 124.753 1.00 38.86  ? 338 ALA B C   1 
ATOM   6972 O O   . ALA D 4 269 ? 121.367 155.525 125.862 1.00 38.86  ? 338 ALA B O   1 
ATOM   6973 C CB  . ALA D 4 269 ? 120.237 152.918 124.552 1.00 38.86  ? 338 ALA B CB  1 
ATOM   6974 N N   . TYR D 4 270 ? 121.357 155.890 123.657 1.00 39.40  ? 339 TYR B N   1 
ATOM   6975 C CA  . TYR D 4 270 ? 122.384 156.913 123.782 1.00 39.40  ? 339 TYR B CA  1 
ATOM   6976 C C   . TYR D 4 270 ? 121.780 158.226 124.252 1.00 39.40  ? 339 TYR B C   1 
ATOM   6977 O O   . TYR D 4 270 ? 122.459 159.044 124.880 1.00 39.40  ? 339 TYR B O   1 
ATOM   6978 C CB  . TYR D 4 270 ? 123.116 157.099 122.459 1.00 39.40  ? 339 TYR B CB  1 
ATOM   6979 C CG  . TYR D 4 270 ? 124.239 158.087 122.546 1.00 39.40  ? 339 TYR B CG  1 
ATOM   6980 C CD1 . TYR D 4 270 ? 125.394 157.778 123.225 1.00 39.40  ? 339 TYR B CD1 1 
ATOM   6981 C CD2 . TYR D 4 270 ? 124.143 159.323 121.955 1.00 39.40  ? 339 TYR B CD2 1 
ATOM   6982 C CE1 . TYR D 4 270 ? 126.410 158.665 123.317 1.00 39.40  ? 339 TYR B CE1 1 
ATOM   6983 C CE2 . TYR D 4 270 ? 125.165 160.217 122.040 1.00 39.40  ? 339 TYR B CE2 1 
ATOM   6984 C CZ  . TYR D 4 270 ? 126.295 159.879 122.724 1.00 39.40  ? 339 TYR B CZ  1 
ATOM   6985 O OH  . TYR D 4 270 ? 127.328 160.771 122.815 1.00 39.40  ? 339 TYR B OH  1 
ATOM   6986 N N   . GLN D 4 271 ? 120.499 158.444 123.961 1.00 42.64  ? 340 GLN B N   1 
ATOM   6987 C CA  . GLN D 4 271 ? 119.807 159.604 124.508 1.00 42.64  ? 340 GLN B CA  1 
ATOM   6988 C C   . GLN D 4 271 ? 119.603 159.467 126.008 1.00 42.64  ? 340 GLN B C   1 
ATOM   6989 O O   . GLN D 4 271 ? 119.740 160.444 126.750 1.00 42.64  ? 340 GLN B O   1 
ATOM   6990 C CB  . GLN D 4 271 ? 118.468 159.799 123.805 1.00 42.64  ? 340 GLN B CB  1 
ATOM   6991 C CG  . GLN D 4 271 ? 118.574 160.332 122.402 1.00 42.64  ? 340 GLN B CG  1 
ATOM   6992 C CD  . GLN D 4 271 ? 117.227 160.437 121.739 1.00 42.64  ? 340 GLN B CD  1 
ATOM   6993 O OE1 . GLN D 4 271 ? 116.222 159.997 122.286 1.00 42.64  ? 340 GLN B OE1 1 
ATOM   6994 N NE2 . GLN D 4 271 ? 117.192 161.036 120.565 1.00 42.64  ? 340 GLN B NE2 1 
ATOM   6995 N N   . LYS D 4 272 ? 119.297 158.256 126.477 1.00 41.17  ? 341 LYS B N   1 
ATOM   6996 C CA  . LYS D 4 272 ? 119.066 158.049 127.902 1.00 41.17  ? 341 LYS B CA  1 
ATOM   6997 C C   . LYS D 4 272 ? 120.369 158.030 128.676 1.00 41.17  ? 341 LYS B C   1 
ATOM   6998 O O   . LYS D 4 272 ? 120.368 158.065 129.908 1.00 41.17  ? 341 LYS B O   1 
ATOM   6999 C CB  . LYS D 4 272 ? 118.304 156.746 128.128 1.00 41.17  ? 341 LYS B CB  1 
ATOM   7000 N N   . LEU D 4 273 ? 121.490 157.966 127.977 1.00 40.84  ? 342 LEU B N   1 
ATOM   7001 C CA  . LEU D 4 273 ? 122.762 157.771 128.647 1.00 40.84  ? 342 LEU B CA  1 
ATOM   7002 C C   . LEU D 4 273 ? 123.364 159.100 129.059 1.00 40.84  ? 342 LEU B C   1 
ATOM   7003 O O   . LEU D 4 273 ? 123.935 159.230 130.145 1.00 40.84  ? 342 LEU B O   1 
ATOM   7004 C CB  . LEU D 4 273 ? 123.691 157.003 127.720 1.00 40.84  ? 342 LEU B CB  1 
ATOM   7005 C CG  . LEU D 4 273 ? 124.931 156.339 128.272 1.00 40.84  ? 342 LEU B CG  1 
ATOM   7006 C CD1 . LEU D 4 273 ? 125.052 155.105 127.459 1.00 40.84  ? 342 LEU B CD1 1 
ATOM   7007 C CD2 . LEU D 4 273 ? 126.158 157.210 128.101 1.00 40.84  ? 342 LEU B CD2 1 
ATOM   7008 N N   . ILE D 4 274 ? 123.264 160.098 128.187 1.00 44.14  ? 343 ILE B N   1 
ATOM   7009 C CA  . ILE D 4 274 ? 123.721 161.436 128.527 1.00 44.14  ? 343 ILE B CA  1 
ATOM   7010 C C   . ILE D 4 274 ? 122.654 162.193 129.305 1.00 44.14  ? 343 ILE B C   1 
ATOM   7011 O O   . ILE D 4 274 ? 122.923 163.263 129.858 1.00 44.14  ? 343 ILE B O   1 
ATOM   7012 C CB  . ILE D 4 274 ? 124.134 162.167 127.242 1.00 44.14  ? 343 ILE B CB  1 
ATOM   7013 C CG1 . ILE D 4 274 ? 122.965 162.188 126.257 1.00 44.14  ? 343 ILE B CG1 1 
ATOM   7014 C CG2 . ILE D 4 274 ? 125.333 161.487 126.621 1.00 44.14  ? 343 ILE B CG2 1 
ATOM   7015 C CD1 . ILE D 4 274 ? 123.205 163.029 125.029 1.00 44.14  ? 343 ILE B CD1 1 
ATOM   7016 N N   . SER D 4 275 ? 121.434 161.656 129.369 1.00 46.09  ? 344 SER B N   1 
ATOM   7017 C CA  . SER D 4 275 ? 120.386 162.297 130.150 1.00 46.09  ? 344 SER B CA  1 
ATOM   7018 C C   . SER D 4 275 ? 120.498 161.967 131.625 1.00 46.09  ? 344 SER B C   1 
ATOM   7019 O O   . SER D 4 275 ? 119.984 162.709 132.465 1.00 46.09  ? 344 SER B O   1 
ATOM   7020 C CB  . SER D 4 275 ? 119.013 161.882 129.639 1.00 46.09  ? 344 SER B CB  1 
ATOM   7021 O OG  . SER D 4 275 ? 118.810 162.334 128.319 1.00 46.09  ? 344 SER B OG  1 
ATOM   7022 N N   . GLU D 4 276 ? 121.133 160.856 131.964 1.00 47.66  ? 345 GLU B N   1 
ATOM   7023 C CA  . GLU D 4 276 ? 121.252 160.414 133.342 1.00 47.66  ? 345 GLU B CA  1 
ATOM   7024 C C   . GLU D 4 276 ? 122.675 160.644 133.816 1.00 47.66  ? 345 GLU B C   1 
ATOM   7025 O O   . GLU D 4 276 ? 123.623 160.165 133.192 1.00 47.66  ? 345 GLU B O   1 
ATOM   7026 C CB  . GLU D 4 276 ? 120.871 158.941 133.472 1.00 47.66  ? 345 GLU B CB  1 
ATOM   7027 N N   . VAL D 4 277 ? 122.826 161.393 134.902 1.00 51.51  ? 346 VAL B N   1 
ATOM   7028 C CA  . VAL D 4 277 ? 124.127 161.644 135.502 1.00 51.51  ? 346 VAL B CA  1 
ATOM   7029 C C   . VAL D 4 277 ? 124.058 161.232 136.960 1.00 51.51  ? 346 VAL B C   1 
ATOM   7030 O O   . VAL D 4 277 ? 123.385 161.889 137.758 1.00 51.51  ? 346 VAL B O   1 
ATOM   7031 C CB  . VAL D 4 277 ? 124.554 163.115 135.391 1.00 51.51  ? 346 VAL B CB  1 
ATOM   7032 C CG1 . VAL D 4 277 ? 125.862 163.326 136.124 1.00 51.51  ? 346 VAL B CG1 1 
ATOM   7033 C CG2 . VAL D 4 277 ? 124.690 163.532 133.941 1.00 51.51  ? 346 VAL B CG2 1 
ATOM   7034 N N   . LYS D 4 278 ? 124.757 160.158 137.308 1.00 52.79  ? 347 LYS B N   1 
ATOM   7035 C CA  . LYS D 4 278 ? 124.862 159.703 138.683 1.00 52.79  ? 347 LYS B CA  1 
ATOM   7036 C C   . LYS D 4 278 ? 126.325 159.476 138.999 1.00 52.79  ? 347 LYS B C   1 
ATOM   7037 O O   . LYS D 4 278 ? 127.158 159.394 138.103 1.00 52.79  ? 347 LYS B O   1 
ATOM   7038 C CB  . LYS D 4 278 ? 124.056 158.436 138.912 1.00 52.79  ? 347 LYS B CB  1 
ATOM   7039 C CG  . LYS D 4 278 ? 124.504 157.276 138.083 1.00 52.79  ? 347 LYS B CG  1 
ATOM   7040 C CD  . LYS D 4 278 ? 123.595 156.102 138.333 1.00 52.79  ? 347 LYS B CD  1 
ATOM   7041 C CE  . LYS D 4 278 ? 122.227 156.368 137.741 1.00 52.79  ? 347 LYS B CE  1 
ATOM   7042 N NZ  . LYS D 4 278 ? 121.336 155.190 137.872 1.00 52.79  ? 347 LYS B NZ  1 
ATOM   7043 N N   . VAL D 4 279 ? 126.637 159.379 140.281 1.00 53.74  ? 348 VAL B N   1 
ATOM   7044 C CA  . VAL D 4 279 ? 128.022 159.358 140.723 1.00 53.74  ? 348 VAL B CA  1 
ATOM   7045 C C   . VAL D 4 279 ? 128.223 158.146 141.615 1.00 53.74  ? 348 VAL B C   1 
ATOM   7046 O O   . VAL D 4 279 ? 127.259 157.555 142.105 1.00 53.74  ? 348 VAL B O   1 
ATOM   7047 C CB  . VAL D 4 279 ? 128.378 160.667 141.468 1.00 53.74  ? 348 VAL B CB  1 
ATOM   7048 C CG1 . VAL D 4 279 ? 127.948 160.635 142.928 1.00 53.74  ? 348 VAL B CG1 1 
ATOM   7049 C CG2 . VAL D 4 279 ? 129.818 161.042 141.300 1.00 53.74  ? 348 VAL B CG2 1 
ATOM   7050 N N   . GLN D 4 280 ? 129.478 157.746 141.790 1.00 54.57  ? 349 GLN B N   1 
ATOM   7051 C CA  . GLN D 4 280 ? 129.823 156.871 142.895 1.00 54.57  ? 349 GLN B CA  1 
ATOM   7052 C C   . GLN D 4 280 ? 131.250 157.158 143.315 1.00 54.57  ? 349 GLN B C   1 
ATOM   7053 O O   . GLN D 4 280 ? 132.061 157.649 142.532 1.00 54.57  ? 349 GLN B O   1 
ATOM   7054 C CB  . GLN D 4 280 ? 129.676 155.386 142.576 1.00 54.57  ? 349 GLN B CB  1 
ATOM   7055 C CG  . GLN D 4 280 ? 130.717 154.816 141.659 1.00 54.57  ? 349 GLN B CG  1 
ATOM   7056 C CD  . GLN D 4 280 ? 130.593 153.317 141.541 1.00 54.57  ? 349 GLN B CD  1 
ATOM   7057 O OE1 . GLN D 4 280 ? 129.718 152.708 142.148 1.00 54.57  ? 349 GLN B OE1 1 
ATOM   7058 N NE2 . GLN D 4 280 ? 131.493 152.708 140.794 1.00 54.57  ? 349 GLN B NE2 1 
ATOM   7059 N N   . VAL D 4 281 ? 131.543 156.843 144.565 1.00 59.37  ? 350 VAL B N   1 
ATOM   7060 C CA  . VAL D 4 281 ? 132.814 157.158 145.188 1.00 59.37  ? 350 VAL B CA  1 
ATOM   7061 C C   . VAL D 4 281 ? 133.589 155.864 145.376 1.00 59.37  ? 350 VAL B C   1 
ATOM   7062 O O   . VAL D 4 281 ? 133.026 154.844 145.789 1.00 59.37  ? 350 VAL B O   1 
ATOM   7063 C CB  . VAL D 4 281 ? 132.598 157.915 146.512 1.00 59.37  ? 350 VAL B CB  1 
ATOM   7064 C CG1 . VAL D 4 281 ? 131.575 157.215 147.385 1.00 59.37  ? 350 VAL B CG1 1 
ATOM   7065 C CG2 . VAL D 4 281 ? 133.896 158.070 147.278 1.00 59.37  ? 350 VAL B CG2 1 
ATOM   7066 N N   . GLU D 4 282 ? 134.858 155.880 144.996 1.00 63.86  ? 351 GLU B N   1 
ATOM   7067 C CA  . GLU D 4 282 ? 135.772 154.805 145.334 1.00 63.86  ? 351 GLU B CA  1 
ATOM   7068 C C   . GLU D 4 282 ? 136.533 155.246 146.570 1.00 63.86  ? 351 GLU B C   1 
ATOM   7069 O O   . GLU D 4 282 ? 137.342 156.174 146.509 1.00 63.86  ? 351 GLU B O   1 
ATOM   7070 C CB  . GLU D 4 282 ? 136.715 154.507 144.175 1.00 63.86  ? 351 GLU B CB  1 
ATOM   7071 N N   . ASN D 4 283 ? 136.268 154.594 147.694 1.00 72.40  ? 352 ASN B N   1 
ATOM   7072 C CA  . ASN D 4 283 ? 136.873 154.955 148.969 1.00 72.40  ? 352 ASN B CA  1 
ATOM   7073 C C   . ASN D 4 283 ? 137.830 153.842 149.364 1.00 72.40  ? 352 ASN B C   1 
ATOM   7074 O O   . ASN D 4 283 ? 137.397 152.738 149.706 1.00 72.40  ? 352 ASN B O   1 
ATOM   7075 C CB  . ASN D 4 283 ? 135.803 155.169 150.035 1.00 72.40  ? 352 ASN B CB  1 
ATOM   7076 C CG  . ASN D 4 283 ? 136.339 155.859 151.268 1.00 72.40  ? 352 ASN B CG  1 
ATOM   7077 O OD1 . ASN D 4 283 ? 137.523 156.174 151.355 1.00 72.40  ? 352 ASN B OD1 1 
ATOM   7078 N ND2 . ASN D 4 283 ? 135.461 156.109 152.231 1.00 72.40  ? 352 ASN B ND2 1 
ATOM   7079 N N   . GLN D 4 284 ? 139.129 154.133 149.314 1.00 76.22  ? 353 GLN B N   1 
ATOM   7080 C CA  . GLN D 4 284 ? 140.164 153.188 149.710 1.00 76.22  ? 353 GLN B CA  1 
ATOM   7081 C C   . GLN D 4 284 ? 140.928 153.625 150.949 1.00 76.22  ? 353 GLN B C   1 
ATOM   7082 O O   . GLN D 4 284 ? 141.941 153.005 151.281 1.00 76.22  ? 353 GLN B O   1 
ATOM   7083 C CB  . GLN D 4 284 ? 141.147 152.962 148.558 1.00 76.22  ? 353 GLN B CB  1 
ATOM   7084 N N   . VAL D 4 285 ? 140.490 154.679 151.627 1.00 77.91  ? 354 VAL B N   1 
ATOM   7085 C CA  . VAL D 4 285 ? 141.093 155.100 152.885 1.00 77.91  ? 354 VAL B CA  1 
ATOM   7086 C C   . VAL D 4 285 ? 140.140 154.735 154.017 1.00 77.91  ? 354 VAL B C   1 
ATOM   7087 O O   . VAL D 4 285 ? 138.917 154.687 153.831 1.00 77.91  ? 354 VAL B O   1 
ATOM   7088 C CB  . VAL D 4 285 ? 141.432 156.607 152.853 1.00 77.91  ? 354 VAL B CB  1 
ATOM   7089 C CG1 . VAL D 4 285 ? 140.187 157.476 152.843 1.00 77.91  ? 354 VAL B CG1 1 
ATOM   7090 C CG2 . VAL D 4 285 ? 142.385 157.000 153.984 1.00 77.91  ? 354 VAL B CG2 1 
ATOM   7091 N N   . GLN D 4 286 ? 140.702 154.412 155.182 1.00 79.94  ? 355 GLN B N   1 
ATOM   7092 C CA  . GLN D 4 286 ? 139.941 153.952 156.333 1.00 79.94  ? 355 GLN B CA  1 
ATOM   7093 C C   . GLN D 4 286 ? 139.632 155.104 157.282 1.00 79.94  ? 355 GLN B C   1 
ATOM   7094 O O   . GLN D 4 286 ? 140.409 156.052 157.416 1.00 79.94  ? 355 GLN B O   1 
ATOM   7095 C CB  . GLN D 4 286 ? 140.705 152.859 157.080 1.00 79.94  ? 355 GLN B CB  1 
ATOM   7096 N N   . GLY D 4 287 ? 138.485 155.003 157.947 1.00 81.99  ? 356 GLY B N   1 
ATOM   7097 C CA  . GLY D 4 287 ? 138.051 156.014 158.887 1.00 81.99  ? 356 GLY B CA  1 
ATOM   7098 C C   . GLY D 4 287 ? 137.401 157.232 158.272 1.00 81.99  ? 356 GLY B C   1 
ATOM   7099 O O   . GLY D 4 287 ? 137.255 158.248 158.960 1.00 81.99  ? 356 GLY B O   1 
ATOM   7100 N N   . ILE D 4 288 ? 137.010 157.163 157.001 1.00 76.66  ? 357 ILE B N   1 
ATOM   7101 C CA  . ILE D 4 288 ? 136.477 158.291 156.250 1.00 76.66  ? 357 ILE B CA  1 
ATOM   7102 C C   . ILE D 4 288 ? 135.153 157.874 155.639 1.00 76.66  ? 357 ILE B C   1 
ATOM   7103 O O   . ILE D 4 288 ? 135.090 156.872 154.922 1.00 76.66  ? 357 ILE B O   1 
ATOM   7104 C CB  . ILE D 4 288 ? 137.457 158.738 155.156 1.00 76.66  ? 357 ILE B CB  1 
ATOM   7105 C CG1 . ILE D 4 288 ? 138.728 159.321 155.770 1.00 76.66  ? 357 ILE B CG1 1 
ATOM   7106 C CG2 . ILE D 4 288 ? 136.797 159.693 154.205 1.00 76.66  ? 357 ILE B CG2 1 
ATOM   7107 C CD1 . ILE D 4 288 ? 138.489 160.556 156.590 1.00 76.66  ? 357 ILE B CD1 1 
ATOM   7108 N N   . TYR D 4 289 ? 134.101 158.629 155.920 1.00 74.38  ? 358 TYR B N   1 
ATOM   7109 C CA  . TYR D 4 289 ? 132.792 158.374 155.339 1.00 74.38  ? 358 TYR B CA  1 
ATOM   7110 C C   . TYR D 4 289 ? 132.399 159.531 154.437 1.00 74.38  ? 358 TYR B C   1 
ATOM   7111 O O   . TYR D 4 289 ? 132.535 160.696 154.816 1.00 74.38  ? 358 TYR B O   1 
ATOM   7112 C CB  . TYR D 4 289 ? 131.732 158.182 156.416 1.00 74.38  ? 358 TYR B CB  1 
ATOM   7113 C CG  . TYR D 4 289 ? 131.854 156.893 157.190 1.00 74.38  ? 358 TYR B CG  1 
ATOM   7114 C CD1 . TYR D 4 289 ? 132.589 155.826 156.693 1.00 74.38  ? 358 TYR B CD1 1 
ATOM   7115 C CD2 . TYR D 4 289 ? 131.243 156.748 158.428 1.00 74.38  ? 358 TYR B CD2 1 
ATOM   7116 C CE1 . TYR D 4 289 ? 132.707 154.646 157.405 1.00 74.38  ? 358 TYR B CE1 1 
ATOM   7117 C CE2 . TYR D 4 289 ? 131.354 155.572 159.150 1.00 74.38  ? 358 TYR B CE2 1 
ATOM   7118 C CZ  . TYR D 4 289 ? 132.087 154.525 158.632 1.00 74.38  ? 358 TYR B CZ  1 
ATOM   7119 O OH  . TYR D 4 289 ? 132.202 153.354 159.344 1.00 74.38  ? 358 TYR B OH  1 
ATOM   7120 N N   . PHE D 4 290 ? 131.912 159.206 153.245 1.00 67.99  ? 359 PHE B N   1 
ATOM   7121 C CA  . PHE D 4 290 ? 131.413 160.191 152.302 1.00 67.99  ? 359 PHE B CA  1 
ATOM   7122 C C   . PHE D 4 290 ? 129.896 160.188 152.298 1.00 67.99  ? 359 PHE B C   1 
ATOM   7123 O O   . PHE D 4 290 ? 129.259 159.160 152.529 1.00 67.99  ? 359 PHE B O   1 
ATOM   7124 C CB  . PHE D 4 290 ? 131.924 159.928 150.890 1.00 67.99  ? 359 PHE B CB  1 
ATOM   7125 C CG  . PHE D 4 290 ? 133.351 160.304 150.689 1.00 67.99  ? 359 PHE B CG  1 
ATOM   7126 C CD1 . PHE D 4 290 ? 133.700 161.619 150.479 1.00 67.99  ? 359 PHE B CD1 1 
ATOM   7127 C CD2 . PHE D 4 290 ? 134.337 159.351 150.698 1.00 67.99  ? 359 PHE B CD2 1 
ATOM   7128 C CE1 . PHE D 4 290 ? 135.003 161.976 150.289 1.00 67.99  ? 359 PHE B CE1 1 
ATOM   7129 C CE2 . PHE D 4 290 ? 135.648 159.707 150.507 1.00 67.99  ? 359 PHE B CE2 1 
ATOM   7130 C CZ  . PHE D 4 290 ? 135.978 161.022 150.303 1.00 67.99  ? 359 PHE B CZ  1 
ATOM   7131 N N   . ASN D 4 291 ? 129.325 161.356 152.026 1.00 64.89  ? 360 ASN B N   1 
ATOM   7132 C CA  . ASN D 4 291 ? 127.877 161.524 152.048 1.00 64.89  ? 360 ASN B CA  1 
ATOM   7133 C C   . ASN D 4 291 ? 127.539 162.521 150.946 1.00 64.89  ? 360 ASN B C   1 
ATOM   7134 O O   . ASN D 4 291 ? 127.638 163.731 151.153 1.00 64.89  ? 360 ASN B O   1 
ATOM   7135 C CB  . ASN D 4 291 ? 127.418 162.008 153.411 1.00 64.89  ? 360 ASN B CB  1 
ATOM   7136 C CG  . ASN D 4 291 ? 125.931 161.881 153.602 1.00 64.89  ? 360 ASN B CG  1 
ATOM   7137 O OD1 . ASN D 4 291 ? 125.211 161.447 152.705 1.00 64.89  ? 360 ASN B OD1 1 
ATOM   7138 N ND2 . ASN D 4 291 ? 125.457 162.251 154.784 1.00 64.89  ? 360 ASN B ND2 1 
ATOM   7139 N N   . ILE D 4 292 ? 127.138 162.010 149.787 1.00 61.32  ? 361 ILE B N   1 
ATOM   7140 C CA  . ILE D 4 292 ? 126.974 162.812 148.584 1.00 61.32  ? 361 ILE B CA  1 
ATOM   7141 C C   . ILE D 4 292 ? 125.488 162.967 148.304 1.00 61.32  ? 361 ILE B C   1 
ATOM   7142 O O   . ILE D 4 292 ? 124.740 161.985 148.317 1.00 61.32  ? 361 ILE B O   1 
ATOM   7143 C CB  . ILE D 4 292 ? 127.706 162.174 147.395 1.00 61.32  ? 361 ILE B CB  1 
ATOM   7144 C CG1 . ILE D 4 292 ? 129.180 162.001 147.733 1.00 61.32  ? 361 ILE B CG1 1 
ATOM   7145 C CG2 . ILE D 4 292 ? 127.602 163.049 146.175 1.00 61.32  ? 361 ILE B CG2 1 
ATOM   7146 C CD1 . ILE D 4 292 ? 129.928 161.158 146.751 1.00 61.32  ? 361 ILE B CD1 1 
ATOM   7147 N N   . THR D 4 293 ? 125.065 164.202 148.056 1.00 61.61  ? 362 THR B N   1 
ATOM   7148 C CA  . THR D 4 293 ? 123.673 164.556 147.826 1.00 61.61  ? 362 THR B CA  1 
ATOM   7149 C C   . THR D 4 293 ? 123.543 165.158 146.437 1.00 61.61  ? 362 THR B C   1 
ATOM   7150 O O   . THR D 4 293 ? 124.315 166.043 146.069 1.00 61.61  ? 362 THR B O   1 
ATOM   7151 C CB  . THR D 4 293 ? 123.202 165.567 148.874 1.00 61.61  ? 362 THR B CB  1 
ATOM   7152 O OG1 . THR D 4 293 ? 123.458 165.053 150.185 1.00 61.61  ? 362 THR B OG1 1 
ATOM   7153 C CG2 . THR D 4 293 ? 121.720 165.826 148.739 1.00 61.61  ? 362 THR B CG2 1 
ATOM   7154 N N   . ALA D 4 294 ? 122.574 164.697 145.665 1.00 60.37  ? 363 ALA B N   1 
ATOM   7155 C CA  . ALA D 4 294 ? 122.392 165.171 144.302 1.00 60.37  ? 363 ALA B CA  1 
ATOM   7156 C C   . ALA D 4 294 ? 121.349 166.275 144.276 1.00 60.37  ? 363 ALA B C   1 
ATOM   7157 O O   . ALA D 4 294 ? 120.222 166.078 144.737 1.00 60.37  ? 363 ALA B O   1 
ATOM   7158 C CB  . ALA D 4 294 ? 121.970 164.036 143.375 1.00 60.37  ? 363 ALA B CB  1 
ATOM   7159 N N   . ILE D 4 295 ? 121.722 167.427 143.733 1.00 59.88  ? 364 ILE B N   1 
ATOM   7160 C CA  . ILE D 4 295 ? 120.789 168.509 143.453 1.00 59.88  ? 364 ILE B CA  1 
ATOM   7161 C C   . ILE D 4 295 ? 120.543 168.512 141.957 1.00 59.88  ? 364 ILE B C   1 
ATOM   7162 O O   . ILE D 4 295 ? 121.462 168.762 141.172 1.00 59.88  ? 364 ILE B O   1 
ATOM   7163 C CB  . ILE D 4 295 ? 121.324 169.872 143.909 1.00 59.88  ? 364 ILE B CB  1 
ATOM   7164 C CG1 . ILE D 4 295 ? 121.523 169.920 145.416 1.00 59.88  ? 364 ILE B CG1 1 
ATOM   7165 C CG2 . ILE D 4 295 ? 120.370 170.958 143.502 1.00 59.88  ? 364 ILE B CG2 1 
ATOM   7166 C CD1 . ILE D 4 295 ? 122.929 169.676 145.847 1.00 59.88  ? 364 ILE B CD1 1 
ATOM   7167 N N   . CYS D 4 296 ? 119.344 168.237 141.568 1.00 63.10  ? 365 CYS B N   1 
ATOM   7168 C CA  . CYS D 4 296 ? 119.039 168.216 140.154 1.00 63.10  ? 365 CYS B CA  1 
ATOM   7169 C C   . CYS D 4 296 ? 118.861 169.632 139.636 1.00 63.10  ? 365 CYS B C   1 
ATOM   7170 O O   . CYS D 4 296 ? 118.590 170.554 140.409 1.00 63.10  ? 365 CYS B O   1 
ATOM   7171 C CB  . CYS D 4 296 ? 117.779 167.391 139.915 1.00 63.10  ? 365 CYS B CB  1 
ATOM   7172 S SG  . CYS D 4 296 ? 118.029 165.652 140.266 1.00 63.10  ? 365 CYS B SG  1 
ATOM   7173 N N   . PRO D 4 297 ? 119.036 169.853 138.328 1.00 63.78  ? 366 PRO B N   1 
ATOM   7174 C CA  . PRO D 4 297 ? 118.646 171.151 137.759 1.00 63.78  ? 366 PRO B CA  1 
ATOM   7175 C C   . PRO D 4 297 ? 117.153 171.396 137.792 1.00 63.78  ? 366 PRO B C   1 
ATOM   7176 O O   . PRO D 4 297 ? 116.721 172.550 137.695 1.00 63.78  ? 366 PRO B O   1 
ATOM   7177 C CB  . PRO D 4 297 ? 119.178 171.076 136.324 1.00 63.78  ? 366 PRO B CB  1 
ATOM   7178 C CG  . PRO D 4 297 ? 119.315 169.634 136.041 1.00 63.78  ? 366 PRO B CG  1 
ATOM   7179 C CD  . PRO D 4 297 ? 119.721 169.013 137.333 1.00 63.78  ? 366 PRO B CD  1 
ATOM   7180 N N   . ASP D 4 298 ? 116.347 170.344 137.922 1.00 66.04  ? 367 ASP B N   1 
ATOM   7181 C CA  . ASP D 4 298 ? 114.942 170.512 138.254 1.00 66.04  ? 367 ASP B CA  1 
ATOM   7182 C C   . ASP D 4 298 ? 114.763 171.093 139.651 1.00 66.04  ? 367 ASP B C   1 
ATOM   7183 O O   . ASP D 4 298 ? 113.762 171.766 139.910 1.00 66.04  ? 367 ASP B O   1 
ATOM   7184 C CB  . ASP D 4 298 ? 114.232 169.164 138.150 1.00 66.04  ? 367 ASP B CB  1 
ATOM   7185 C CG  . ASP D 4 298 ? 112.728 169.293 138.036 1.00 66.04  ? 367 ASP B CG  1 
ATOM   7186 O OD1 . ASP D 4 298 ? 112.215 170.427 137.955 1.00 66.04  ? 367 ASP B OD1 1 
ATOM   7187 O OD2 . ASP D 4 298 ? 112.049 168.245 138.028 1.00 66.04  ? 367 ASP B OD2 1 
ATOM   7188 N N   . GLY D 4 299 ? 115.720 170.867 140.547 1.00 66.48  ? 368 GLY B N   1 
ATOM   7189 C CA  . GLY D 4 299 ? 115.619 171.261 141.930 1.00 66.48  ? 368 GLY B CA  1 
ATOM   7190 C C   . GLY D 4 299 ? 115.295 170.121 142.867 1.00 66.48  ? 368 GLY B C   1 
ATOM   7191 O O   . GLY D 4 299 ? 115.376 170.296 144.086 1.00 66.48  ? 368 GLY B O   1 
ATOM   7192 N N   . SER D 4 300 ? 114.936 168.964 142.325 1.00 65.80  ? 369 SER B N   1 
ATOM   7193 C CA  . SER D 4 300 ? 114.599 167.811 143.142 1.00 65.80  ? 369 SER B CA  1 
ATOM   7194 C C   . SER D 4 300 ? 115.863 167.205 143.732 1.00 65.80  ? 369 SER B C   1 
ATOM   7195 O O   . SER D 4 300 ? 116.810 166.893 143.011 1.00 65.80  ? 369 SER B O   1 
ATOM   7196 C CB  . SER D 4 300 ? 113.853 166.783 142.301 1.00 65.80  ? 369 SER B CB  1 
ATOM   7197 O OG  . SER D 4 300 ? 112.638 167.325 141.817 1.00 65.80  ? 369 SER B OG  1 
ATOM   7198 N N   . ARG D 4 301 ? 115.877 167.038 145.045 1.00 65.56  ? 370 ARG B N   1 
ATOM   7199 C CA  . ARG D 4 301 ? 117.075 166.657 145.776 1.00 65.56  ? 370 ARG B CA  1 
ATOM   7200 C C   . ARG D 4 301 ? 117.087 165.146 145.962 1.00 65.56  ? 370 ARG B C   1 
ATOM   7201 O O   . ARG D 4 301 ? 116.278 164.605 146.722 1.00 65.56  ? 370 ARG B O   1 
ATOM   7202 C CB  . ARG D 4 301 ? 117.110 167.385 147.116 1.00 65.56  ? 370 ARG B CB  1 
ATOM   7203 C CG  . ARG D 4 301 ? 118.391 167.251 147.900 1.00 65.56  ? 370 ARG B CG  1 
ATOM   7204 C CD  . ARG D 4 301 ? 118.299 168.086 149.170 1.00 65.56  ? 370 ARG B CD  1 
ATOM   7205 N NE  . ARG D 4 301 ? 118.236 169.513 148.870 1.00 65.56  ? 370 ARG B NE  1 
ATOM   7206 C CZ  . ARG D 4 301 ? 119.300 170.298 148.759 1.00 65.56  ? 370 ARG B CZ  1 
ATOM   7207 N NH1 . ARG D 4 301 ? 120.513 169.805 148.949 1.00 65.56  ? 370 ARG B NH1 1 
ATOM   7208 N NH2 . ARG D 4 301 ? 119.150 171.581 148.476 1.00 65.56  ? 370 ARG B NH2 1 
ATOM   7209 N N   . LYS D 4 302 ? 118.006 164.475 145.276 1.00 62.51  ? 371 LYS B N   1 
ATOM   7210 C CA  . LYS D 4 302 ? 118.076 163.020 145.211 1.00 62.51  ? 371 LYS B CA  1 
ATOM   7211 C C   . LYS D 4 302 ? 119.351 162.554 145.904 1.00 62.51  ? 371 LYS B C   1 
ATOM   7212 O O   . LYS D 4 302 ? 120.221 163.385 146.186 1.00 62.51  ? 371 LYS B O   1 
ATOM   7213 C CB  . LYS D 4 302 ? 118.034 162.575 143.748 1.00 62.51  ? 371 LYS B CB  1 
ATOM   7214 C CG  . LYS D 4 302 ? 116.780 162.996 143.029 1.00 62.51  ? 371 LYS B CG  1 
ATOM   7215 C CD  . LYS D 4 302 ? 115.562 162.370 143.655 1.00 62.51  ? 371 LYS B CD  1 
ATOM   7216 C CE  . LYS D 4 302 ? 115.497 160.888 143.366 1.00 62.51  ? 371 LYS B CE  1 
ATOM   7217 N NZ  . LYS D 4 302 ? 114.260 160.270 143.921 1.00 62.51  ? 371 LYS B NZ  1 
ATOM   7218 N N   . PRO D 4 303 ? 119.503 161.272 146.233 1.00 60.46  ? 372 PRO B N   1 
ATOM   7219 C CA  . PRO D 4 303 ? 120.796 160.797 146.736 1.00 60.46  ? 372 PRO B CA  1 
ATOM   7220 C C   . PRO D 4 303 ? 121.859 160.844 145.654 1.00 60.46  ? 372 PRO B C   1 
ATOM   7221 O O   . PRO D 4 303 ? 121.569 160.969 144.466 1.00 60.46  ? 372 PRO B O   1 
ATOM   7222 C CB  . PRO D 4 303 ? 120.509 159.360 147.163 1.00 60.46  ? 372 PRO B CB  1 
ATOM   7223 C CG  . PRO D 4 303 ? 119.065 159.338 147.428 1.00 60.46  ? 372 PRO B CG  1 
ATOM   7224 C CD  . PRO D 4 303 ? 118.453 160.261 146.434 1.00 60.46  ? 372 PRO B CD  1 
ATOM   7225 N N   . GLY D 4 304 ? 123.114 160.718 146.086 1.00 59.89  ? 373 GLY B N   1 
ATOM   7226 C CA  . GLY D 4 304 ? 124.230 160.935 145.175 1.00 59.89  ? 373 GLY B CA  1 
ATOM   7227 C C   . GLY D 4 304 ? 124.351 159.862 144.110 1.00 59.89  ? 373 GLY B C   1 
ATOM   7228 O O   . GLY D 4 304 ? 124.612 160.157 142.942 1.00 59.89  ? 373 GLY B O   1 
ATOM   7229 N N   . MET D 4 305 ? 124.156 158.605 144.494 1.00 60.51  ? 374 MET B N   1 
ATOM   7230 C CA  . MET D 4 305 ? 124.220 157.518 143.531 1.00 60.51  ? 374 MET B CA  1 
ATOM   7231 C C   . MET D 4 305 ? 122.924 157.340 142.771 1.00 60.51  ? 374 MET B C   1 
ATOM   7232 O O   . MET D 4 305 ? 122.900 156.586 141.798 1.00 60.51  ? 374 MET B O   1 
ATOM   7233 C CB  . MET D 4 305 ? 124.594 156.214 144.231 1.00 60.51  ? 374 MET B CB  1 
ATOM   7234 C CG  . MET D 4 305 ? 125.984 156.262 144.826 1.00 60.51  ? 374 MET B CG  1 
ATOM   7235 S SD  . MET D 4 305 ? 126.543 154.768 145.653 1.00 60.51  ? 374 MET B SD  1 
ATOM   7236 C CE  . MET D 4 305 ? 128.124 155.345 146.268 1.00 60.51  ? 374 MET B CE  1 
ATOM   7237 N N   . GLU D 4 306 ? 121.850 158.001 143.192 1.00 59.82  ? 375 GLU B N   1 
ATOM   7238 C CA  . GLU D 4 306 ? 120.625 157.960 142.409 1.00 59.82  ? 375 GLU B CA  1 
ATOM   7239 C C   . GLU D 4 306 ? 120.755 158.839 141.184 1.00 59.82  ? 375 GLU B C   1 
ATOM   7240 O O   . GLU D 4 306 ? 120.413 158.430 140.071 1.00 59.82  ? 375 GLU B O   1 
ATOM   7241 C CB  . GLU D 4 306 ? 119.437 158.399 143.258 1.00 59.82  ? 375 GLU B CB  1 
ATOM   7242 C CG  . GLU D 4 306 ? 118.115 158.345 142.524 1.00 59.82  ? 375 GLU B CG  1 
ATOM   7243 C CD  . GLU D 4 306 ? 117.671 156.930 142.204 1.00 59.82  ? 375 GLU B CD  1 
ATOM   7244 O OE1 . GLU D 4 306 ? 118.018 156.001 142.964 1.00 59.82  ? 375 GLU B OE1 1 
ATOM   7245 O OE2 . GLU D 4 306 ? 116.976 156.743 141.183 1.00 59.82  ? 375 GLU B OE2 1 
ATOM   7246 N N   . GLY D 4 307 ? 121.256 160.049 141.369 1.00 58.03  ? 376 GLY B N   1 
ATOM   7247 C CA  . GLY D 4 307 ? 121.543 160.918 140.255 1.00 58.03  ? 376 GLY B CA  1 
ATOM   7248 C C   . GLY D 4 307 ? 120.317 161.608 139.705 1.00 58.03  ? 376 GLY B C   1 
ATOM   7249 O O   . GLY D 4 307 ? 119.190 161.438 140.166 1.00 58.03  ? 376 GLY B O   1 
ATOM   7250 N N   . CYS D 4 308 ? 120.556 162.403 138.673 1.00 56.70  ? 377 CYS B N   1 
ATOM   7251 C CA  . CYS D 4 308 ? 119.536 163.254 138.089 1.00 56.70  ? 377 CYS B CA  1 
ATOM   7252 C C   . CYS D 4 308 ? 119.272 162.854 136.651 1.00 56.70  ? 377 CYS B C   1 
ATOM   7253 O O   . CYS D 4 308 ? 120.199 162.731 135.852 1.00 56.70  ? 377 CYS B O   1 
ATOM   7254 C CB  . CYS D 4 308 ? 119.962 164.718 138.156 1.00 56.70  ? 377 CYS B CB  1 
ATOM   7255 S SG  . CYS D 4 308 ? 119.994 165.371 139.837 1.00 56.70  ? 377 CYS B SG  1 
ATOM   7256 N N   . ARG D 4 309 ? 118.005 162.655 136.329 1.00 51.75  ? 378 ARG B N   1 
ATOM   7257 C CA  . ARG D 4 309 ? 117.586 162.325 134.981 1.00 51.75  ? 378 ARG B CA  1 
ATOM   7258 C C   . ARG D 4 309 ? 117.207 163.596 134.241 1.00 51.75  ? 378 ARG B C   1 
ATOM   7259 O O   . ARG D 4 309 ? 117.206 164.689 134.806 1.00 51.75  ? 378 ARG B O   1 
ATOM   7260 C CB  . ARG D 4 309 ? 116.411 161.349 135.005 1.00 51.75  ? 378 ARG B CB  1 
ATOM   7261 N N   . ASN D 4 310 ? 116.899 163.431 132.952 1.00 49.61  ? 379 ASN B N   1 
ATOM   7262 C CA  . ASN D 4 310 ? 116.515 164.495 132.022 1.00 49.61  ? 379 ASN B CA  1 
ATOM   7263 C C   . ASN D 4 310 ? 117.562 165.596 131.914 1.00 49.61  ? 379 ASN B C   1 
ATOM   7264 O O   . ASN D 4 310 ? 117.227 166.749 131.651 1.00 49.61  ? 379 ASN B O   1 
ATOM   7265 C CB  . ASN D 4 310 ? 115.157 165.097 132.387 1.00 49.61  ? 379 ASN B CB  1 
ATOM   7266 C CG  . ASN D 4 310 ? 114.025 164.127 132.188 1.00 49.61  ? 379 ASN B CG  1 
ATOM   7267 O OD1 . ASN D 4 310 ? 113.997 163.390 131.211 1.00 49.61  ? 379 ASN B OD1 1 
ATOM   7268 N ND2 . ASN D 4 310 ? 113.077 164.123 133.114 1.00 49.61  ? 379 ASN B ND2 1 
ATOM   7269 N N   . VAL D 4 311 ? 118.833 165.261 132.118 1.00 49.50  ? 380 VAL B N   1 
ATOM   7270 C CA  . VAL D 4 311 ? 119.885 166.254 132.035 1.00 49.50  ? 380 VAL B CA  1 
ATOM   7271 C C   . VAL D 4 311 ? 120.241 166.482 130.580 1.00 49.50  ? 380 VAL B C   1 
ATOM   7272 O O   . VAL D 4 311 ? 120.491 165.542 129.823 1.00 49.50  ? 380 VAL B O   1 
ATOM   7273 C CB  . VAL D 4 311 ? 121.114 165.793 132.835 1.00 49.50  ? 380 VAL B CB  1 
ATOM   7274 C CG1 . VAL D 4 311 ? 122.229 166.788 132.720 1.00 49.50  ? 380 VAL B CG1 1 
ATOM   7275 C CG2 . VAL D 4 311 ? 120.740 165.592 134.265 1.00 49.50  ? 380 VAL B CG2 1 
ATOM   7276 N N   . THR D 4 312 ? 120.270 167.741 130.176 1.00 52.17  ? 381 THR B N   1 
ATOM   7277 C CA  . THR D 4 312 ? 120.770 168.047 128.850 1.00 52.17  ? 381 THR B CA  1 
ATOM   7278 C C   . THR D 4 312 ? 122.149 168.652 129.006 1.00 52.17  ? 381 THR B C   1 
ATOM   7279 O O   . THR D 4 312 ? 122.658 168.759 130.119 1.00 52.17  ? 381 THR B O   1 
ATOM   7280 C CB  . THR D 4 312 ? 119.840 169.002 128.120 1.00 52.17  ? 381 THR B CB  1 
ATOM   7281 O OG1 . THR D 4 312 ? 119.791 170.241 128.826 1.00 52.17  ? 381 THR B OG1 1 
ATOM   7282 C CG2 . THR D 4 312 ? 118.447 168.423 128.057 1.00 52.17  ? 381 THR B CG2 1 
ATOM   7283 N N   . SER D 4 313 ? 122.766 169.061 127.917 1.00 53.52  ? 382 SER B N   1 
ATOM   7284 C CA  . SER D 4 313 ? 123.921 169.931 128.027 1.00 53.52  ? 382 SER B CA  1 
ATOM   7285 C C   . SER D 4 313 ? 123.423 171.327 128.361 1.00 53.52  ? 382 SER B C   1 
ATOM   7286 O O   . SER D 4 313 ? 122.224 171.577 128.348 1.00 53.52  ? 382 SER B O   1 
ATOM   7287 C CB  . SER D 4 313 ? 124.748 169.898 126.754 1.00 53.52  ? 382 SER B CB  1 
ATOM   7288 O OG  . SER D 4 313 ? 125.833 170.797 126.857 1.00 53.52  ? 382 SER B OG  1 
ATOM   7289 N N   . ASN D 4 314 ? 124.347 172.241 128.648 1.00 55.89  ? 383 ASN B N   1 
ATOM   7290 C CA  . ASN D 4 314 ? 124.157 173.547 129.298 1.00 55.89  ? 383 ASN B CA  1 
ATOM   7291 C C   . ASN D 4 314 ? 123.408 173.445 130.634 1.00 55.89  ? 383 ASN B C   1 
ATOM   7292 O O   . ASN D 4 314 ? 122.818 174.426 131.099 1.00 55.89  ? 383 ASN B O   1 
ATOM   7293 C CB  . ASN D 4 314 ? 123.558 174.620 128.337 1.00 55.89  ? 383 ASN B CB  1 
ATOM   7294 C CG  . ASN D 4 314 ? 122.018 174.528 128.034 1.00 55.89  ? 383 ASN B CG  1 
ATOM   7295 O OD1 . ASN D 4 314 ? 121.181 174.054 128.806 1.00 55.89  ? 383 ASN B OD1 1 
ATOM   7296 N ND2 . ASN D 4 314 ? 121.674 174.991 126.834 1.00 55.89  ? 383 ASN B ND2 1 
ATOM   7297 N N   . ASP D 4 315 ? 123.462 172.282 131.285 1.00 54.73  ? 384 ASP B N   1 
ATOM   7298 C CA  . ASP D 4 315 ? 123.000 172.083 132.647 1.00 54.73  ? 384 ASP B CA  1 
ATOM   7299 C C   . ASP D 4 315 ? 124.217 171.693 133.462 1.00 54.73  ? 384 ASP B C   1 
ATOM   7300 O O   . ASP D 4 315 ? 125.089 170.982 132.964 1.00 54.73  ? 384 ASP B O   1 
ATOM   7301 C CB  . ASP D 4 315 ? 121.949 170.978 132.753 1.00 54.73  ? 384 ASP B CB  1 
ATOM   7302 C CG  . ASP D 4 315 ? 120.686 171.306 132.016 1.00 54.73  ? 384 ASP B CG  1 
ATOM   7303 O OD1 . ASP D 4 315 ? 120.423 172.498 131.787 1.00 54.73  ? 384 ASP B OD1 1 
ATOM   7304 O OD2 . ASP D 4 315 ? 119.932 170.375 131.691 1.00 54.73  ? 384 ASP B OD2 1 
ATOM   7305 N N   . GLU D 4 316 ? 124.283 172.151 134.705 1.00 53.97  ? 385 GLU B N   1 
ATOM   7306 C CA  . GLU D 4 316 ? 125.407 171.838 135.581 1.00 53.97  ? 385 GLU B CA  1 
ATOM   7307 C C   . GLU D 4 316 ? 124.846 171.126 136.801 1.00 53.97  ? 385 GLU B C   1 
ATOM   7308 O O   . GLU D 4 316 ? 124.371 171.779 137.731 1.00 53.97  ? 385 GLU B O   1 
ATOM   7309 C CB  . GLU D 4 316 ? 126.171 173.094 135.970 1.00 53.97  ? 385 GLU B CB  1 
ATOM   7310 N N   . VAL D 4 317 ? 124.896 169.795 136.792 1.00 55.33  ? 386 VAL B N   1 
ATOM   7311 C CA  . VAL D 4 317 ? 124.357 169.010 137.894 1.00 55.33  ? 386 VAL B CA  1 
ATOM   7312 C C   . VAL D 4 317 ? 125.289 169.129 139.086 1.00 55.33  ? 386 VAL B C   1 
ATOM   7313 O O   . VAL D 4 317 ? 126.502 168.930 138.964 1.00 55.33  ? 386 VAL B O   1 
ATOM   7314 C CB  . VAL D 4 317 ? 124.180 167.544 137.476 1.00 55.33  ? 386 VAL B CB  1 
ATOM   7315 C CG1 . VAL D 4 317 ? 123.615 166.724 138.616 1.00 55.33  ? 386 VAL B CG1 1 
ATOM   7316 C CG2 . VAL D 4 317 ? 123.285 167.453 136.270 1.00 55.33  ? 386 VAL B CG2 1 
ATOM   7317 N N   . LEU D 4 318 ? 124.729 169.457 140.243 1.00 55.80  ? 387 LEU B N   1 
ATOM   7318 C CA  . LEU D 4 318 ? 125.517 169.684 141.440 1.00 55.80  ? 387 LEU B CA  1 
ATOM   7319 C C   . LEU D 4 318 ? 125.395 168.521 142.411 1.00 55.80  ? 387 LEU B C   1 
ATOM   7320 O O   . LEU D 4 318 ? 124.305 168.016 142.674 1.00 55.80  ? 387 LEU B O   1 
ATOM   7321 C CB  . LEU D 4 318 ? 125.089 170.975 142.122 1.00 55.80  ? 387 LEU B CB  1 
ATOM   7322 C CG  . LEU D 4 318 ? 125.480 172.255 141.401 1.00 55.80  ? 387 LEU B CG  1 
ATOM   7323 C CD1 . LEU D 4 318 ? 124.875 173.444 142.094 1.00 55.80  ? 387 LEU B CD1 1 
ATOM   7324 C CD2 . LEU D 4 318 ? 126.971 172.379 141.382 1.00 55.80  ? 387 LEU B CD2 1 
ATOM   7325 N N   . PHE D 4 319 ? 126.538 168.104 142.945 1.00 58.63  ? 388 PHE B N   1 
ATOM   7326 C CA  . PHE D 4 319 ? 126.629 167.012 143.905 1.00 58.63  ? 388 PHE B CA  1 
ATOM   7327 C C   . PHE D 4 319 ? 127.239 167.566 145.180 1.00 58.63  ? 388 PHE B C   1 
ATOM   7328 O O   . PHE D 4 319 ? 128.451 167.780 145.247 1.00 58.63  ? 388 PHE B O   1 
ATOM   7329 C CB  . PHE D 4 319 ? 127.468 165.864 143.351 1.00 58.63  ? 388 PHE B CB  1 
ATOM   7330 C CG  . PHE D 4 319 ? 126.787 165.081 142.269 1.00 58.63  ? 388 PHE B CG  1 
ATOM   7331 C CD1 . PHE D 4 319 ? 125.413 165.039 142.181 1.00 58.63  ? 388 PHE B CD1 1 
ATOM   7332 C CD2 . PHE D 4 319 ? 127.526 164.422 141.313 1.00 58.63  ? 388 PHE B CD2 1 
ATOM   7333 C CE1 . PHE D 4 319 ? 124.792 164.330 141.177 1.00 58.63  ? 388 PHE B CE1 1 
ATOM   7334 C CE2 . PHE D 4 319 ? 126.903 163.717 140.305 1.00 58.63  ? 388 PHE B CE2 1 
ATOM   7335 C CZ  . PHE D 4 319 ? 125.536 163.669 140.245 1.00 58.63  ? 388 PHE B CZ  1 
ATOM   7336 N N   . ASN D 4 320 ? 126.409 167.797 146.186 1.00 61.90  ? 389 ASN B N   1 
ATOM   7337 C CA  . ASN D 4 320 ? 126.860 168.378 147.440 1.00 61.90  ? 389 ASN B CA  1 
ATOM   7338 C C   . ASN D 4 320 ? 127.497 167.270 148.260 1.00 61.90  ? 389 ASN B C   1 
ATOM   7339 O O   . ASN D 4 320 ? 126.795 166.444 148.844 1.00 61.90  ? 389 ASN B O   1 
ATOM   7340 C CB  . ASN D 4 320 ? 125.676 169.004 148.163 1.00 61.90  ? 389 ASN B CB  1 
ATOM   7341 C CG  . ASN D 4 320 ? 126.078 169.990 149.230 1.00 61.90  ? 389 ASN B CG  1 
ATOM   7342 O OD1 . ASN D 4 320 ? 127.252 170.214 149.490 1.00 61.90  ? 389 ASN B OD1 1 
ATOM   7343 N ND2 . ASN D 4 320 ? 125.075 170.600 149.850 1.00 61.90  ? 389 ASN B ND2 1 
ATOM   7344 N N   . VAL D 4 321 ? 128.822 167.238 148.296 1.00 63.86  ? 390 VAL B N   1 
ATOM   7345 C CA  . VAL D 4 321 ? 129.567 166.149 148.910 1.00 63.86  ? 390 VAL B CA  1 
ATOM   7346 C C   . VAL D 4 321 ? 129.936 166.544 150.327 1.00 63.86  ? 390 VAL B C   1 
ATOM   7347 O O   . VAL D 4 321 ? 130.500 167.620 150.549 1.00 63.86  ? 390 VAL B O   1 
ATOM   7348 C CB  . VAL D 4 321 ? 130.827 165.817 148.100 1.00 63.86  ? 390 VAL B CB  1 
ATOM   7349 C CG1 . VAL D 4 321 ? 131.589 164.685 148.748 1.00 63.86  ? 390 VAL B CG1 1 
ATOM   7350 C CG2 . VAL D 4 321 ? 130.464 165.476 146.679 1.00 63.86  ? 390 VAL B CG2 1 
ATOM   7351 N N   . THR D 4 322 ? 129.637 165.671 151.286 1.00 67.78  ? 391 THR B N   1 
ATOM   7352 C CA  . THR D 4 322 ? 129.988 165.878 152.684 1.00 67.78  ? 391 THR B CA  1 
ATOM   7353 C C   . THR D 4 322 ? 130.824 164.697 153.144 1.00 67.78  ? 391 THR B C   1 
ATOM   7354 O O   . THR D 4 322 ? 130.430 163.546 152.948 1.00 67.78  ? 391 THR B O   1 
ATOM   7355 C CB  . THR D 4 322 ? 128.736 166.016 153.542 1.00 67.78  ? 391 THR B CB  1 
ATOM   7356 O OG1 . THR D 4 322 ? 127.939 167.092 153.041 1.00 67.78  ? 391 THR B OG1 1 
ATOM   7357 C CG2 . THR D 4 322 ? 129.108 166.314 154.973 1.00 67.78  ? 391 THR B CG2 1 
ATOM   7358 N N   . VAL D 4 323 ? 131.973 164.974 153.744 1.00 73.35  ? 392 VAL B N   1 
ATOM   7359 C CA  . VAL D 4 323 ? 132.899 163.942 154.189 1.00 73.35  ? 392 VAL B CA  1 
ATOM   7360 C C   . VAL D 4 323 ? 133.196 164.142 155.672 1.00 73.35  ? 392 VAL B C   1 
ATOM   7361 O O   . VAL D 4 323 ? 133.364 165.275 156.137 1.00 73.35  ? 392 VAL B O   1 
ATOM   7362 C CB  . VAL D 4 323 ? 134.169 163.949 153.310 1.00 73.35  ? 392 VAL B CB  1 
ATOM   7363 C CG1 . VAL D 4 323 ? 134.801 165.311 153.244 1.00 73.35  ? 392 VAL B CG1 1 
ATOM   7364 C CG2 . VAL D 4 323 ? 135.183 162.957 153.796 1.00 73.35  ? 392 VAL B CG2 1 
ATOM   7365 N N   . THR D 4 324 ? 133.200 163.041 156.428 1.00 78.34  ? 393 THR B N   1 
ATOM   7366 C CA  . THR D 4 324 ? 133.489 163.057 157.855 1.00 78.34  ? 393 THR B CA  1 
ATOM   7367 C C   . THR D 4 324 ? 134.686 162.166 158.153 1.00 78.34  ? 393 THR B C   1 
ATOM   7368 O O   . THR D 4 324 ? 135.278 161.568 157.255 1.00 78.34  ? 393 THR B O   1 
ATOM   7369 C CB  . THR D 4 324 ? 132.291 162.588 158.684 1.00 78.34  ? 393 THR B CB  1 
ATOM   7370 O OG1 . THR D 4 324 ? 131.957 161.245 158.318 1.00 78.34  ? 393 THR B OG1 1 
ATOM   7371 C CG2 . THR D 4 324 ? 131.091 163.485 158.450 1.00 78.34  ? 393 THR B CG2 1 
ATOM   7372 N N   . MET D 4 325 ? 135.042 162.089 159.433 1.00 86.19  ? 394 MET B N   1 
ATOM   7373 C CA  . MET D 4 325 ? 136.160 161.277 159.894 1.00 86.19  ? 394 MET B CA  1 
ATOM   7374 C C   . MET D 4 325 ? 135.830 160.683 161.256 1.00 86.19  ? 394 MET B C   1 
ATOM   7375 O O   . MET D 4 325 ? 135.203 161.331 162.095 1.00 86.19  ? 394 MET B O   1 
ATOM   7376 C CB  . MET D 4 325 ? 137.454 162.104 159.967 1.00 86.19  ? 394 MET B CB  1 
ATOM   7377 C CG  . MET D 4 325 ? 138.711 161.301 160.224 1.00 86.19  ? 394 MET B CG  1 
ATOM   7378 S SD  . MET D 4 325 ? 140.198 162.289 160.034 1.00 86.19  ? 394 MET B SD  1 
ATOM   7379 C CE  . MET D 4 325 ? 141.455 161.070 160.385 1.00 86.19  ? 394 MET B CE  1 
ATOM   7380 N N   . LYS D 4 326 ? 136.253 159.439 161.471 1.00 89.69  ? 395 LYS B N   1 
ATOM   7381 C CA  . LYS D 4 326 ? 135.932 158.740 162.708 1.00 89.69  ? 395 LYS B CA  1 
ATOM   7382 C C   . LYS D 4 326 ? 137.168 158.486 163.565 1.00 89.69  ? 395 LYS B C   1 
ATOM   7383 O O   . LYS D 4 326 ? 137.111 158.626 164.790 1.00 89.69  ? 395 LYS B O   1 
ATOM   7384 C CB  . LYS D 4 326 ? 135.224 157.421 162.400 1.00 89.69  ? 395 LYS B CB  1 
ATOM   7385 N N   . LYS D 4 327 ? 138.286 158.115 162.943 1.00 92.54  ? 396 LYS B N   1 
ATOM   7386 C CA  . LYS D 4 327 ? 139.514 157.858 163.682 1.00 92.54  ? 396 LYS B CA  1 
ATOM   7387 C C   . LYS D 4 327 ? 140.708 158.063 162.764 1.00 92.54  ? 396 LYS B C   1 
ATOM   7388 O O   . LYS D 4 327 ? 140.591 157.996 161.539 1.00 92.54  ? 396 LYS B O   1 
ATOM   7389 C CB  . LYS D 4 327 ? 139.536 156.442 164.267 1.00 92.54  ? 396 LYS B CB  1 
ATOM   7390 N N   . CYS D 4 328 ? 141.864 158.307 163.373 1.00 97.77  ? 397 CYS B N   1 
ATOM   7391 C CA  . CYS D 4 328 ? 143.098 158.507 162.629 1.00 97.77  ? 397 CYS B CA  1 
ATOM   7392 C C   . CYS D 4 328 ? 143.791 157.177 162.361 1.00 97.77  ? 397 CYS B C   1 
ATOM   7393 O O   . CYS D 4 328 ? 143.420 156.132 162.900 1.00 97.77  ? 397 CYS B O   1 
ATOM   7394 C CB  . CYS D 4 328 ? 144.053 159.436 163.380 1.00 97.77  ? 397 CYS B CB  1 
ATOM   7395 S SG  . CYS D 4 328 ? 143.522 161.155 163.504 1.00 97.77  ? 397 CYS B SG  1 
ATOM   7396 N N   . ASP D 4 329 ? 144.811 157.232 161.513 1.00 100.30 ? 398 ASP B N   1 
ATOM   7397 C CA  . ASP D 4 329 ? 145.632 156.067 161.219 1.00 100.30 ? 398 ASP B CA  1 
ATOM   7398 C C   . ASP D 4 329 ? 147.030 156.531 160.825 1.00 100.30 ? 398 ASP B C   1 
ATOM   7399 O O   . ASP D 4 329 ? 147.333 156.679 159.642 1.00 100.30 ? 398 ASP B O   1 
ATOM   7400 C CB  . ASP D 4 329 ? 145.006 155.228 160.101 1.00 100.30 ? 398 ASP B CB  1 
ATOM   7401 C CG  . ASP D 4 329 ? 145.617 153.840 159.988 1.00 100.30 ? 398 ASP B CG  1 
ATOM   7402 O OD1 . ASP D 4 329 ? 146.516 153.498 160.782 1.00 100.30 ? 398 ASP B OD1 1 
ATOM   7403 O OD2 . ASP D 4 329 ? 145.192 153.084 159.091 1.00 100.30 ? 398 ASP B OD2 1 
ATOM   7404 N N   . ASN D 4 335 ? 146.993 159.252 151.087 1.00 77.67  ? 404 ASN B N   1 
ATOM   7405 C CA  . ASN D 4 335 ? 146.042 158.391 150.402 1.00 77.67  ? 404 ASN B CA  1 
ATOM   7406 C C   . ASN D 4 335 ? 144.874 159.262 149.937 1.00 77.67  ? 404 ASN B C   1 
ATOM   7407 O O   . ASN D 4 335 ? 144.691 160.368 150.444 1.00 77.67  ? 404 ASN B O   1 
ATOM   7408 C CB  . ASN D 4 335 ? 145.581 157.261 151.324 1.00 77.67  ? 404 ASN B CB  1 
ATOM   7409 C CG  . ASN D 4 335 ? 144.979 156.093 150.568 1.00 77.67  ? 404 ASN B CG  1 
ATOM   7410 O OD1 . ASN D 4 335 ? 144.822 156.142 149.353 1.00 77.67  ? 404 ASN B OD1 1 
ATOM   7411 N ND2 . ASN D 4 335 ? 144.675 155.020 151.284 1.00 77.67  ? 404 ASN B ND2 1 
ATOM   7412 N N   . TYR D 4 336 ? 144.092 158.779 148.973 1.00 75.45  ? 405 TYR B N   1 
ATOM   7413 C CA  . TYR D 4 336 ? 143.104 159.623 148.313 1.00 75.45  ? 405 TYR B CA  1 
ATOM   7414 C C   . TYR D 4 336 ? 141.902 158.784 147.908 1.00 75.45  ? 405 TYR B C   1 
ATOM   7415 O O   . TYR D 4 336 ? 141.971 157.557 147.829 1.00 75.45  ? 405 TYR B O   1 
ATOM   7416 C CB  . TYR D 4 336 ? 143.709 160.331 147.099 1.00 75.45  ? 405 TYR B CB  1 
ATOM   7417 N N   . ALA D 4 337 ? 140.799 159.472 147.639 1.00 69.89  ? 406 ALA B N   1 
ATOM   7418 C CA  . ALA D 4 337 ? 139.583 158.862 147.132 1.00 69.89  ? 406 ALA B CA  1 
ATOM   7419 C C   . ALA D 4 337 ? 139.176 159.562 145.846 1.00 69.89  ? 406 ALA B C   1 
ATOM   7420 O O   . ALA D 4 337 ? 139.493 160.730 145.620 1.00 69.89  ? 406 ALA B O   1 
ATOM   7421 C CB  . ALA D 4 337 ? 138.452 158.936 148.161 1.00 69.89  ? 406 ALA B CB  1 
ATOM   7422 N N   . ILE D 4 338 ? 138.462 158.838 144.993 1.00 64.38  ? 407 ILE B N   1 
ATOM   7423 C CA  . ILE D 4 338 ? 138.109 159.332 143.671 1.00 64.38  ? 407 ILE B CA  1 
ATOM   7424 C C   . ILE D 4 338 ? 136.600 159.239 143.505 1.00 64.38  ? 407 ILE B C   1 
ATOM   7425 O O   . ILE D 4 338 ? 136.037 158.141 143.539 1.00 64.38  ? 407 ILE B O   1 
ATOM   7426 C CB  . ILE D 4 338 ? 138.817 158.558 142.557 1.00 64.38  ? 407 ILE B CB  1 
ATOM   7427 C CG1 . ILE D 4 338 ? 140.321 158.788 142.618 1.00 64.38  ? 407 ILE B CG1 1 
ATOM   7428 C CG2 . ILE D 4 338 ? 138.286 158.971 141.213 1.00 64.38  ? 407 ILE B CG2 1 
ATOM   7429 C CD1 . ILE D 4 338 ? 141.089 157.895 141.691 1.00 64.38  ? 407 ILE B CD1 1 
ATOM   7430 N N   . ILE D 4 339 ? 135.949 160.379 143.313 1.00 59.54  ? 408 ILE B N   1 
ATOM   7431 C CA  . ILE D 4 339 ? 134.508 160.452 143.119 1.00 59.54  ? 408 ILE B CA  1 
ATOM   7432 C C   . ILE D 4 339 ? 134.250 160.702 141.643 1.00 59.54  ? 408 ILE B C   1 
ATOM   7433 O O   . ILE D 4 339 ? 134.573 161.776 141.129 1.00 59.54  ? 408 ILE B O   1 
ATOM   7434 C CB  . ILE D 4 339 ? 133.890 161.558 143.986 1.00 59.54  ? 408 ILE B CB  1 
ATOM   7435 C CG1 . ILE D 4 339 ? 134.063 161.244 145.467 1.00 59.54  ? 408 ILE B CG1 1 
ATOM   7436 C CG2 . ILE D 4 339 ? 132.444 161.700 143.719 1.00 59.54  ? 408 ILE B CG2 1 
ATOM   7437 C CD1 . ILE D 4 339 ? 133.605 162.353 146.389 1.00 59.54  ? 408 ILE B CD1 1 
ATOM   7438 N N   . LYS D 4 340 ? 133.667 159.725 140.950 1.00 51.61  ? 409 LYS B N   1 
ATOM   7439 C CA  . LYS D 4 340 ? 133.522 159.846 139.513 1.00 51.61  ? 409 LYS B CA  1 
ATOM   7440 C C   . LYS D 4 340 ? 132.106 159.564 139.034 1.00 51.61  ? 409 LYS B C   1 
ATOM   7441 O O   . LYS D 4 340 ? 131.410 158.718 139.608 1.00 51.61  ? 409 LYS B O   1 
ATOM   7442 C CB  . LYS D 4 340 ? 134.497 158.911 138.789 1.00 51.61  ? 409 LYS B CB  1 
ATOM   7443 C CG  . LYS D 4 340 ? 134.296 157.440 139.051 1.00 51.61  ? 409 LYS B CG  1 
ATOM   7444 C CD  . LYS D 4 340 ? 135.294 156.601 138.292 1.00 51.61  ? 409 LYS B CD  1 
ATOM   7445 C CE  . LYS D 4 340 ? 134.967 156.565 136.818 1.00 51.61  ? 409 LYS B CE  1 
ATOM   7446 N NZ  . LYS D 4 340 ? 135.873 155.639 136.094 1.00 51.61  ? 409 LYS B NZ  1 
ATOM   7447 N N   . PRO D 4 341 ? 131.647 160.264 138.006 1.00 49.54  ? 410 PRO B N   1 
ATOM   7448 C CA  . PRO D 4 341 ? 130.339 159.960 137.437 1.00 49.54  ? 410 PRO B CA  1 
ATOM   7449 C C   . PRO D 4 341 ? 130.388 158.715 136.580 1.00 49.54  ? 410 PRO B C   1 
ATOM   7450 O O   . PRO D 4 341 ? 131.388 158.416 135.929 1.00 49.54  ? 410 PRO B O   1 
ATOM   7451 C CB  . PRO D 4 341 ? 130.034 161.189 136.582 1.00 49.54  ? 410 PRO B CB  1 
ATOM   7452 C CG  . PRO D 4 341 ? 130.898 162.226 137.107 1.00 49.54  ? 410 PRO B CG  1 
ATOM   7453 C CD  . PRO D 4 341 ? 132.148 161.548 137.511 1.00 49.54  ? 410 PRO B CD  1 
ATOM   7454 N N   . ILE D 4 342 ? 129.277 157.989 136.576 1.00 49.95  ? 411 ILE B N   1 
ATOM   7455 C CA  . ILE D 4 342 ? 129.218 156.694 135.911 1.00 49.95  ? 411 ILE B CA  1 
ATOM   7456 C C   . ILE D 4 342 ? 129.026 156.929 134.419 1.00 49.95  ? 411 ILE B C   1 
ATOM   7457 O O   . ILE D 4 342 ? 127.972 157.391 133.981 1.00 49.95  ? 411 ILE B O   1 
ATOM   7458 C CB  . ILE D 4 342 ? 128.107 155.815 136.490 1.00 49.95  ? 411 ILE B CB  1 
ATOM   7459 C CG1 . ILE D 4 342 ? 128.417 155.493 137.949 1.00 49.95  ? 411 ILE B CG1 1 
ATOM   7460 C CG2 . ILE D 4 342 ? 127.981 154.531 135.705 1.00 49.95  ? 411 ILE B CG2 1 
ATOM   7461 C CD1 . ILE D 4 342 ? 127.294 154.815 138.675 1.00 49.95  ? 411 ILE B CD1 1 
ATOM   7462 N N   . GLY D 4 343 ? 130.053 156.627 133.638 1.00 47.10  ? 412 GLY B N   1 
ATOM   7463 C CA  . GLY D 4 343 ? 129.988 156.759 132.205 1.00 47.10  ? 412 GLY B CA  1 
ATOM   7464 C C   . GLY D 4 343 ? 130.736 157.926 131.608 1.00 47.10  ? 412 GLY B C   1 
ATOM   7465 O O   . GLY D 4 343 ? 130.537 158.217 130.427 1.00 47.10  ? 412 GLY B O   1 
ATOM   7466 N N   . PHE D 4 344 ? 131.575 158.603 132.372 1.00 46.48  ? 413 PHE B N   1 
ATOM   7467 C CA  . PHE D 4 344 ? 132.338 159.727 131.863 1.00 46.48  ? 413 PHE B CA  1 
ATOM   7468 C C   . PHE D 4 344 ? 133.807 159.373 131.895 1.00 46.48  ? 413 PHE B C   1 
ATOM   7469 O O   . PHE D 4 344 ? 134.215 158.479 132.636 1.00 46.48  ? 413 PHE B O   1 
ATOM   7470 C CB  . PHE D 4 344 ? 132.091 160.998 132.677 1.00 46.48  ? 413 PHE B CB  1 
ATOM   7471 C CG  . PHE D 4 344 ? 130.756 161.633 132.427 1.00 46.48  ? 413 PHE B CG  1 
ATOM   7472 C CD1 . PHE D 4 344 ? 129.993 161.270 131.342 1.00 46.48  ? 413 PHE B CD1 1 
ATOM   7473 C CD2 . PHE D 4 344 ? 130.279 162.609 133.261 1.00 46.48  ? 413 PHE B CD2 1 
ATOM   7474 C CE1 . PHE D 4 344 ? 128.774 161.851 131.106 1.00 46.48  ? 413 PHE B CE1 1 
ATOM   7475 C CE2 . PHE D 4 344 ? 129.063 163.191 133.025 1.00 46.48  ? 413 PHE B CE2 1 
ATOM   7476 C CZ  . PHE D 4 344 ? 128.312 162.816 131.949 1.00 46.48  ? 413 PHE B CZ  1 
ATOM   7477 N N   . ASN D 4 345 ? 134.604 160.075 131.094 1.00 47.24  ? 414 ASN B N   1 
ATOM   7478 C CA  . ASN D 4 345 ? 136.016 159.737 131.022 1.00 47.24  ? 414 ASN B CA  1 
ATOM   7479 C C   . ASN D 4 345 ? 136.811 160.415 132.125 1.00 47.24  ? 414 ASN B C   1 
ATOM   7480 O O   . ASN D 4 345 ? 137.846 159.903 132.559 1.00 47.24  ? 414 ASN B O   1 
ATOM   7481 C CB  . ASN D 4 345 ? 136.581 160.085 129.648 1.00 47.24  ? 414 ASN B CB  1 
ATOM   7482 C CG  . ASN D 4 345 ? 136.486 161.555 129.311 1.00 47.24  ? 414 ASN B CG  1 
ATOM   7483 O OD1 . ASN D 4 345 ? 135.887 162.351 130.025 1.00 47.24  ? 414 ASN B OD1 1 
ATOM   7484 N ND2 . ASN D 4 345 ? 137.116 161.924 128.221 1.00 47.24  ? 414 ASN B ND2 1 
ATOM   7485 N N   . GLU D 4 346 ? 136.358 161.574 132.577 1.00 52.13  ? 415 GLU B N   1 
ATOM   7486 C CA  . GLU D 4 346 ? 137.064 162.330 133.597 1.00 52.13  ? 415 GLU B CA  1 
ATOM   7487 C C   . GLU D 4 346 ? 136.507 162.013 134.976 1.00 52.13  ? 415 GLU B C   1 
ATOM   7488 O O   . GLU D 4 346 ? 135.312 161.754 135.131 1.00 52.13  ? 415 GLU B O   1 
ATOM   7489 C CB  . GLU D 4 346 ? 136.952 163.826 133.319 1.00 52.13  ? 415 GLU B CB  1 
ATOM   7490 N N   . THR D 4 347 ? 137.383 162.025 135.973 1.00 57.41  ? 416 THR B N   1 
ATOM   7491 C CA  . THR D 4 347 ? 137.039 161.752 137.360 1.00 57.41  ? 416 THR B CA  1 
ATOM   7492 C C   . THR D 4 347 ? 137.345 162.982 138.201 1.00 57.41  ? 416 THR B C   1 
ATOM   7493 O O   . THR D 4 347 ? 137.687 164.044 137.684 1.00 57.41  ? 416 THR B O   1 
ATOM   7494 C CB  . THR D 4 347 ? 137.820 160.561 137.903 1.00 57.41  ? 416 THR B CB  1 
ATOM   7495 O OG1 . THR D 4 347 ? 139.201 160.914 137.994 1.00 57.41  ? 416 THR B OG1 1 
ATOM   7496 C CG2 . THR D 4 347 ? 137.692 159.367 136.989 1.00 57.41  ? 416 THR B CG2 1 
ATOM   7497 N N   . ALA D 4 348 ? 137.241 162.825 139.515 1.00 62.21  ? 417 ALA B N   1 
ATOM   7498 C CA  . ALA D 4 348 ? 137.611 163.866 140.464 1.00 62.21  ? 417 ALA B CA  1 
ATOM   7499 C C   . ALA D 4 348 ? 138.396 163.238 141.601 1.00 62.21  ? 417 ALA B C   1 
ATOM   7500 O O   . ALA D 4 348 ? 137.900 162.329 142.270 1.00 62.21  ? 417 ALA B O   1 
ATOM   7501 C CB  . ALA D 4 348 ? 136.381 164.584 140.997 1.00 62.21  ? 417 ALA B CB  1 
ATOM   7502 N N   . LYS D 4 349 ? 139.606 163.727 141.824 1.00 68.90  ? 418 LYS B N   1 
ATOM   7503 C CA  . LYS D 4 349 ? 140.533 163.130 142.773 1.00 68.90  ? 418 LYS B CA  1 
ATOM   7504 C C   . LYS D 4 349 ? 140.521 163.943 144.058 1.00 68.90  ? 418 LYS B C   1 
ATOM   7505 O O   . LYS D 4 349 ? 140.861 165.128 144.047 1.00 68.90  ? 418 LYS B O   1 
ATOM   7506 C CB  . LYS D 4 349 ? 141.938 163.082 142.180 1.00 68.90  ? 418 LYS B CB  1 
ATOM   7507 N N   . ILE D 4 350 ? 140.141 163.313 145.161 1.00 70.17  ? 419 ILE B N   1 
ATOM   7508 C CA  . ILE D 4 350 ? 139.994 163.992 146.440 1.00 70.17  ? 419 ILE B CA  1 
ATOM   7509 C C   . ILE D 4 350 ? 141.087 163.482 147.359 1.00 70.17  ? 419 ILE B C   1 
ATOM   7510 O O   . ILE D 4 350 ? 141.075 162.317 147.771 1.00 70.17  ? 419 ILE B O   1 
ATOM   7511 C CB  . ILE D 4 350 ? 138.607 163.774 147.054 1.00 70.17  ? 419 ILE B CB  1 
ATOM   7512 C CG1 . ILE D 4 350 ? 137.528 164.472 146.227 1.00 70.17  ? 419 ILE B CG1 1 
ATOM   7513 C CG2 . ILE D 4 350 ? 138.569 164.316 148.463 1.00 70.17  ? 419 ILE B CG2 1 
ATOM   7514 C CD1 . ILE D 4 350 ? 136.864 163.626 145.178 1.00 70.17  ? 419 ILE B CD1 1 
ATOM   7515 N N   . HIS D 4 351 ? 142.042 164.340 147.676 1.00 75.49  ? 420 HIS B N   1 
ATOM   7516 C CA  . HIS D 4 351 ? 143.093 163.963 148.601 1.00 75.49  ? 420 HIS B CA  1 
ATOM   7517 C C   . HIS D 4 351 ? 142.658 164.237 150.033 1.00 75.49  ? 420 HIS B C   1 
ATOM   7518 O O   . HIS D 4 351 ? 141.851 165.132 150.300 1.00 75.49  ? 420 HIS B O   1 
ATOM   7519 C CB  . HIS D 4 351 ? 144.377 164.727 148.295 1.00 75.49  ? 420 HIS B CB  1 
ATOM   7520 N N   . ILE D 4 352 ? 143.199 163.452 150.959 1.00 75.79  ? 421 ILE B N   1 
ATOM   7521 C CA  . ILE D 4 352 ? 142.892 163.622 152.371 1.00 75.79  ? 421 ILE B CA  1 
ATOM   7522 C C   . ILE D 4 352 ? 144.141 164.028 153.132 1.00 75.79  ? 421 ILE B C   1 
ATOM   7523 O O   . ILE D 4 352 ? 144.827 164.968 152.746 1.00 75.79  ? 421 ILE B O   1 
ATOM   7524 C CB  . ILE D 4 352 ? 142.276 162.357 152.963 1.00 75.79  ? 421 ILE B CB  1 
ATOM   7525 C CG1 . ILE D 4 352 ? 140.973 162.024 152.245 1.00 75.79  ? 421 ILE B CG1 1 
ATOM   7526 C CG2 . ILE D 4 352 ? 142.018 162.540 154.435 1.00 75.79  ? 421 ILE B CG2 1 
ATOM   7527 C CD1 . ILE D 4 352 ? 139.931 163.101 152.359 1.00 75.79  ? 421 ILE B CD1 1 
HETATM 7528 C C1  . NAG E 5 .   ? 108.011 123.854 145.437 1.00 40.10  ? 1   NAG C C1  1 
HETATM 7529 C C2  . NAG E 5 .   ? 106.532 123.495 145.355 1.00 40.10  ? 1   NAG C C2  1 
HETATM 7530 C C3  . NAG E 5 .   ? 106.262 122.589 144.155 1.00 40.10  ? 1   NAG C C3  1 
HETATM 7531 C C4  . NAG E 5 .   ? 106.868 123.140 142.871 1.00 40.10  ? 1   NAG C C4  1 
HETATM 7532 C C5  . NAG E 5 .   ? 108.328 123.503 143.097 1.00 40.10  ? 1   NAG C C5  1 
HETATM 7533 C C6  . NAG E 5 .   ? 108.950 124.208 141.920 1.00 40.10  ? 1   NAG C C6  1 
HETATM 7534 C C7  . NAG E 5 .   ? 105.568 123.497 147.609 1.00 40.10  ? 1   NAG C C7  1 
HETATM 7535 C C8  . NAG E 5 .   ? 105.191 122.662 148.791 1.00 40.10  ? 1   NAG C C8  1 
HETATM 7536 N N2  . NAG E 5 .   ? 106.103 122.842 146.577 1.00 40.10  ? 1   NAG C N2  1 
HETATM 7537 O O3  . NAG E 5 .   ? 104.856 122.451 143.999 1.00 40.10  ? 1   NAG C O3  1 
HETATM 7538 O O4  . NAG E 5 .   ? 106.847 122.115 141.886 1.00 40.10  ? 1   NAG C O4  1 
HETATM 7539 O O5  . NAG E 5 .   ? 108.436 124.396 144.209 1.00 40.10  ? 1   NAG C O5  1 
HETATM 7540 O O6  . NAG E 5 .   ? 107.989 125.001 141.240 1.00 40.10  ? 1   NAG C O6  1 
HETATM 7541 O O7  . NAG E 5 .   ? 105.397 124.707 147.590 1.00 40.10  ? 1   NAG C O7  1 
HETATM 7542 C C1  . NAG E 5 .   ? 105.979 122.316 140.771 1.00 47.27  ? 2   NAG C C1  1 
HETATM 7543 C C2  . NAG E 5 .   ? 106.426 121.285 139.750 1.00 47.27  ? 2   NAG C C2  1 
HETATM 7544 C C3  . NAG E 5 .   ? 105.493 121.280 138.549 1.00 47.27  ? 2   NAG C C3  1 
HETATM 7545 C C4  . NAG E 5 .   ? 104.051 121.085 138.992 1.00 47.27  ? 2   NAG C C4  1 
HETATM 7546 C C5  . NAG E 5 .   ? 103.699 122.161 140.018 1.00 47.27  ? 2   NAG C C5  1 
HETATM 7547 C C6  . NAG E 5 .   ? 102.327 122.009 140.631 1.00 47.27  ? 2   NAG C C6  1 
HETATM 7548 C C7  . NAG E 5 .   ? 108.813 120.735 139.638 1.00 47.27  ? 2   NAG C C7  1 
HETATM 7549 C C8  . NAG E 5 .   ? 110.154 121.158 139.130 1.00 47.27  ? 2   NAG C C8  1 
HETATM 7550 N N2  . NAG E 5 .   ? 107.792 121.537 139.328 1.00 47.27  ? 2   NAG C N2  1 
HETATM 7551 O O3  . NAG E 5 .   ? 105.877 120.235 137.666 1.00 47.27  ? 2   NAG C O3  1 
HETATM 7552 O O4  . NAG E 5 .   ? 103.214 121.155 137.844 1.00 47.27  ? 2   NAG C O4  1 
HETATM 7553 O O5  . NAG E 5 .   ? 104.632 122.103 141.107 1.00 47.27  ? 2   NAG C O5  1 
HETATM 7554 O O6  . NAG E 5 .   ? 102.237 122.690 141.874 1.00 47.27  ? 2   NAG C O6  1 
HETATM 7555 O O7  . NAG E 5 .   ? 108.661 119.717 140.300 1.00 47.27  ? 2   NAG C O7  1 
HETATM 7556 C C1  . BMA E 5 .   ? 102.438 119.945 137.695 1.00 57.21  ? 3   BMA C C1  1 
HETATM 7557 C C2  . BMA E 5 .   ? 101.100 120.426 137.156 1.00 57.21  ? 3   BMA C C2  1 
HETATM 7558 C C3  . BMA E 5 .   ? 100.149 119.248 137.051 1.00 57.21  ? 3   BMA C C3  1 
HETATM 7559 C C4  . BMA E 5 .   ? 100.760 118.102 136.252 1.00 57.21  ? 3   BMA C C4  1 
HETATM 7560 C C5  . BMA E 5 .   ? 102.180 117.760 136.778 1.00 57.21  ? 3   BMA C C5  1 
HETATM 7561 C C6  . BMA E 5 .   ? 102.875 116.674 135.966 1.00 57.21  ? 3   BMA C C6  1 
HETATM 7562 O O2  . BMA E 5 .   ? 101.256 120.919 135.850 1.00 57.21  ? 3   BMA C O2  1 
HETATM 7563 O O3  . BMA E 5 .   ? 98.952  119.634 136.426 1.00 57.21  ? 3   BMA C O3  1 
HETATM 7564 O O4  . BMA E 5 .   ? 99.925  116.965 136.347 1.00 57.21  ? 3   BMA C O4  1 
HETATM 7565 O O5  . BMA E 5 .   ? 102.978 118.973 136.804 1.00 57.21  ? 3   BMA C O5  1 
HETATM 7566 O O6  . BMA E 5 .   ? 103.732 117.250 134.967 1.00 57.21  ? 3   BMA C O6  1 
HETATM 7567 C C1  . MAN E 5 .   ? 97.847  119.591 137.345 1.00 65.64  ? 4   MAN C C1  1 
HETATM 7568 C C2  . MAN E 5 .   ? 96.692  120.320 136.639 1.00 65.64  ? 4   MAN C C2  1 
HETATM 7569 C C3  . MAN E 5 .   ? 96.182  121.465 137.502 1.00 65.64  ? 4   MAN C C3  1 
HETATM 7570 C C4  . MAN E 5 .   ? 95.831  120.962 138.904 1.00 65.64  ? 4   MAN C C4  1 
HETATM 7571 C C5  . MAN E 5 .   ? 97.107  120.413 139.580 1.00 65.64  ? 4   MAN C C5  1 
HETATM 7572 C C6  . MAN E 5 .   ? 96.886  119.128 140.364 1.00 65.64  ? 4   MAN C C6  1 
HETATM 7573 O O2  . MAN E 5 .   ? 95.576  119.454 136.460 1.00 65.64  ? 4   MAN C O2  1 
HETATM 7574 O O3  . MAN E 5 .   ? 95.055  122.104 136.913 1.00 65.64  ? 4   MAN C O3  1 
HETATM 7575 O O4  . MAN E 5 .   ? 95.302  122.021 139.685 1.00 65.64  ? 4   MAN C O4  1 
HETATM 7576 O O5  . MAN E 5 .   ? 98.178  120.182 138.600 1.00 65.64  ? 4   MAN C O5  1 
HETATM 7577 O O6  . MAN E 5 .   ? 96.420  119.476 141.665 1.00 65.64  ? 4   MAN C O6  1 
HETATM 7578 C C1  . MAN E 5 .   ? 103.188 117.108 133.625 1.00 57.97  ? 5   MAN C C1  1 
HETATM 7579 C C2  . MAN E 5 .   ? 102.941 115.598 133.286 1.00 57.97  ? 5   MAN C C2  1 
HETATM 7580 C C3  . MAN E 5 .   ? 104.252 114.892 132.998 1.00 57.97  ? 5   MAN C C3  1 
HETATM 7581 C C4  . MAN E 5 .   ? 105.039 115.636 131.915 1.00 57.97  ? 5   MAN C C4  1 
HETATM 7582 C C5  . MAN E 5 .   ? 105.324 117.060 132.408 1.00 57.97  ? 5   MAN C C5  1 
HETATM 7583 C C6  . MAN E 5 .   ? 106.062 117.885 131.396 1.00 57.97  ? 5   MAN C C6  1 
HETATM 7584 O O2  . MAN E 5 .   ? 102.182 115.470 132.090 1.00 57.97  ? 5   MAN C O2  1 
HETATM 7585 O O3  . MAN E 5 .   ? 104.053 113.542 132.613 1.00 57.97  ? 5   MAN C O3  1 
HETATM 7586 O O4  . MAN E 5 .   ? 106.264 114.967 131.652 1.00 57.97  ? 5   MAN C O4  1 
HETATM 7587 O O5  . MAN E 5 .   ? 104.062 117.715 132.661 1.00 57.97  ? 5   MAN C O5  1 
HETATM 7588 O O6  . MAN E 5 .   ? 105.125 118.754 130.774 1.00 57.97  ? 5   MAN C O6  1 
HETATM 7589 C C1  . NAG F 6 .   ? 149.135 113.890 134.326 1.00 43.72  ? 501 NAG A C1  1 
HETATM 7590 C C2  . NAG F 6 .   ? 149.548 115.305 134.665 1.00 43.72  ? 501 NAG A C2  1 
HETATM 7591 C C3  . NAG F 6 .   ? 149.350 116.211 133.452 1.00 43.72  ? 501 NAG A C3  1 
HETATM 7592 C C4  . NAG F 6 .   ? 150.062 115.650 132.226 1.00 43.72  ? 501 NAG A C4  1 
HETATM 7593 C C5  . NAG F 6 .   ? 149.666 114.196 131.998 1.00 43.72  ? 501 NAG A C5  1 
HETATM 7594 C C6  . NAG F 6 .   ? 150.468 113.530 130.907 1.00 43.72  ? 501 NAG A C6  1 
HETATM 7595 C C7  . NAG F 6 .   ? 149.307 115.946 137.022 1.00 43.72  ? 501 NAG A C7  1 
HETATM 7596 C C8  . NAG F 6 .   ? 148.373 116.459 138.069 1.00 43.72  ? 501 NAG A C8  1 
HETATM 7597 N N2  . NAG F 6 .   ? 148.790 115.799 135.800 1.00 43.72  ? 501 NAG A N2  1 
HETATM 7598 O O3  . NAG F 6 .   ? 149.840 117.514 133.750 1.00 43.72  ? 501 NAG A O3  1 
HETATM 7599 O O4  . NAG F 6 .   ? 149.711 116.396 131.066 1.00 43.72  ? 501 NAG A O4  1 
HETATM 7600 O O5  . NAG F 6 .   ? 149.879 113.432 133.195 1.00 43.72  ? 501 NAG A O5  1 
HETATM 7601 O O6  . NAG F 6 .   ? 151.567 112.810 131.446 1.00 43.72  ? 501 NAG A O6  1 
HETATM 7602 O O7  . NAG F 6 .   ? 150.473 115.682 137.269 1.00 43.72  ? 501 NAG A O7  1 
HETATM 7603 C C1  . NAG G 6 .   ? 103.814 110.349 149.533 1.00 54.15  ? 502 NAG A C1  1 
HETATM 7604 C C2  . NAG G 6 .   ? 102.492 110.233 148.783 1.00 54.15  ? 502 NAG A C2  1 
HETATM 7605 C C3  . NAG G 6 .   ? 101.489 111.248 149.323 1.00 54.15  ? 502 NAG A C3  1 
HETATM 7606 C C4  . NAG G 6 .   ? 101.347 111.114 150.833 1.00 54.15  ? 502 NAG A C4  1 
HETATM 7607 C C5  . NAG G 6 .   ? 102.717 111.194 151.496 1.00 54.15  ? 502 NAG A C5  1 
HETATM 7608 C C6  . NAG G 6 .   ? 102.666 110.943 152.982 1.00 54.15  ? 502 NAG A C6  1 
HETATM 7609 C C7  . NAG G 6 .   ? 102.657 109.419 146.475 1.00 54.15  ? 502 NAG A C7  1 
HETATM 7610 C C8  . NAG G 6 .   ? 102.883 109.795 145.042 1.00 54.15  ? 502 NAG A C8  1 
HETATM 7611 N N2  . NAG G 6 .   ? 102.689 110.423 147.356 1.00 54.15  ? 502 NAG A N2  1 
HETATM 7612 O O3  . NAG G 6 .   ? 100.228 111.045 148.697 1.00 54.15  ? 502 NAG A O3  1 
HETATM 7613 O O4  . NAG G 6 .   ? 100.524 112.157 151.341 1.00 54.15  ? 502 NAG A O4  1 
HETATM 7614 O O5  . NAG G 6 .   ? 103.584 110.197 150.936 1.00 54.15  ? 502 NAG A O5  1 
HETATM 7615 O O6  . NAG G 6 .   ? 101.775 111.847 153.621 1.00 54.15  ? 502 NAG A O6  1 
HETATM 7616 O O7  . NAG G 6 .   ? 102.454 108.260 146.819 1.00 54.15  ? 502 NAG A O7  1 
HETATM 7617 C C1  . NAG H 6 .   ? 125.159 171.577 150.900 1.00 65.16  ? 501 NAG B C1  1 
HETATM 7618 C C2  . NAG H 6 .   ? 123.971 172.518 150.754 1.00 65.16  ? 501 NAG B C2  1 
HETATM 7619 C C3  . NAG H 6 .   ? 123.903 173.475 151.935 1.00 65.16  ? 501 NAG B C3  1 
HETATM 7620 C C4  . NAG H 6 .   ? 123.856 172.699 153.243 1.00 65.16  ? 501 NAG B C4  1 
HETATM 7621 C C5  . NAG H 6 .   ? 125.062 171.776 153.323 1.00 65.16  ? 501 NAG B C5  1 
HETATM 7622 C C6  . NAG H 6 .   ? 125.048 170.883 154.539 1.00 65.16  ? 501 NAG B C6  1 
HETATM 7623 C C7  . NAG H 6 .   ? 122.983 173.363 148.688 1.00 65.16  ? 501 NAG B C7  1 
HETATM 7624 C C8  . NAG H 6 .   ? 123.202 174.159 147.442 1.00 65.16  ? 501 NAG B C8  1 
HETATM 7625 N N2  . NAG H 6 .   ? 124.031 173.253 149.505 1.00 65.16  ? 501 NAG B N2  1 
HETATM 7626 O O3  . NAG H 6 .   ? 122.749 174.299 151.814 1.00 65.16  ? 501 NAG B O3  1 
HETATM 7627 O O4  . NAG H 6 .   ? 123.880 173.597 154.346 1.00 65.16  ? 501 NAG B O4  1 
HETATM 7628 O O5  . NAG H 6 .   ? 125.095 170.913 152.177 1.00 65.16  ? 501 NAG B O5  1 
HETATM 7629 O O6  . NAG H 6 .   ? 123.857 170.110 154.593 1.00 65.16  ? 501 NAG B O6  1 
HETATM 7630 O O7  . NAG H 6 .   ? 121.908 172.842 148.945 1.00 65.16  ? 501 NAG B O7  1 
HETATM 7631 C C1  . NAG I 6 .   ? 137.153 163.287 127.801 1.00 46.67  ? 502 NAG B C1  1 
HETATM 7632 C C2  . NAG I 6 .   ? 138.623 163.657 127.648 1.00 46.67  ? 502 NAG B C2  1 
HETATM 7633 C C3  . NAG I 6 .   ? 138.758 165.066 127.088 1.00 46.67  ? 502 NAG B C3  1 
HETATM 7634 C C4  . NAG I 6 .   ? 137.958 165.210 125.802 1.00 46.67  ? 502 NAG B C4  1 
HETATM 7635 C C5  . NAG I 6 .   ? 136.513 164.801 126.050 1.00 46.67  ? 502 NAG B C5  1 
HETATM 7636 C C6  . NAG I 6 .   ? 135.682 164.790 124.798 1.00 46.67  ? 502 NAG B C6  1 
HETATM 7637 C C7  . NAG I 6 .   ? 140.080 162.500 129.247 1.00 46.67  ? 502 NAG B C7  1 
HETATM 7638 C C8  . NAG I 6 .   ? 140.724 162.557 130.595 1.00 46.67  ? 502 NAG B C8  1 
HETATM 7639 N N2  . NAG I 6 .   ? 139.320 163.547 128.918 1.00 46.67  ? 502 NAG B N2  1 
HETATM 7640 O O3  . NAG I 6 .   ? 140.131 165.339 126.841 1.00 46.67  ? 502 NAG B O3  1 
HETATM 7641 O O4  . NAG I 6 .   ? 138.004 166.558 125.348 1.00 46.67  ? 502 NAG B O4  1 
HETATM 7642 O O5  . NAG I 6 .   ? 136.482 163.463 126.560 1.00 46.67  ? 502 NAG B O5  1 
HETATM 7643 O O6  . NAG I 6 .   ? 134.931 163.589 124.722 1.00 46.67  ? 502 NAG B O6  1 
HETATM 7644 O O7  . NAG I 6 .   ? 140.233 161.549 128.496 1.00 46.67  ? 502 NAG B O7  1 
# 
