data_9ILS
# 
_entry.id   9ILS 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9ILS         pdb_00009ils 10.2210/pdb9ils/pdb 
WWPDB D_1300049010 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-03-05 ? 
2 'Structure model' 1 1 2025-05-28 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_audit_revision_group.ordinal             1 
_pdbx_audit_revision_group.revision_ordinal    2 
_pdbx_audit_revision_group.data_content_type   'Structure model' 
_pdbx_audit_revision_group.group               'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1 2 'Structure model' '_citation.journal_volume'          
2 2 'Structure model' '_citation.page_first'              
3 2 'Structure model' '_citation.page_last'               
4 2 'Structure model' '_citation_author.identifier_ORCID' 
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9ILS 
_pdbx_database_status.recvd_initial_deposition_date   2024-07-01 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBJ 
_pdbx_database_status.process_site                    PDBJ 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              xiewei6@mail.sysu.edu.cn 
_pdbx_contact_author.name_first         Wei 
_pdbx_contact_author.name_last          Xie 
_pdbx_contact_author.name_mi            ? 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-2410-2135 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Xie, W.'  1 ? 
'Chen, R.' 2 ? 
'Zhao, H.' 3 ? 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   NE 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            'Febs Lett.' 
_citation.journal_id_ASTM           FEBLAL 
_citation.journal_id_CSD            0165 
_citation.journal_id_ISSN           0014-5793 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            599 
_citation.language                  ? 
_citation.page_first                1246 
_citation.page_last                 1259 
_citation.title                     'Structural insights into the Shigella flexneri GmvAT toxin-antitoxin system.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1002/1873-3468.70015 
_citation.pdbx_database_id_PubMed   39973444 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Chen, R.'  1  ? 
primary 'Zhao, H.'  2  ? 
primary 'Zhou, J.'  3  ? 
primary 'Liu, A.'   4  ? 
primary 'Guo, Y.'   5  ? 
primary 'Wu, K.'    6  ? 
primary 'Xiang, Y.' 7  ? 
primary 'Lei, J.'   8  ? 
primary 'Jiang, S.' 9  ? 
primary 'Xie, W.'   10 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man N-acetyltransferase                 18870.719 1 ? Q100R ? ?                     
2 polymer     man 'DUF1778 domain-containing protein' 4973.642  1 ? ?     ? 'GenBank: UUR52005.1' 
3 non-polymer syn 'PHOSPHATE ION'                     94.971    1 ? ?     ? ?                     
4 water       nat water                               18.015    2 ? ?     ? ?                     
# 
_entity_name_com.entity_id   1 
_entity_name_com.name        GmvT 
# 
loop_
_entity_poly.entity_id 
_entity_poly.type 
_entity_poly.nstd_linkage 
_entity_poly.nstd_monomer 
_entity_poly.pdbx_seq_one_letter_code 
_entity_poly.pdbx_seq_one_letter_code_can 
_entity_poly.pdbx_strand_id 
_entity_poly.pdbx_target_identifier 
1 'polypeptide(L)' no no 
;MEINVTAPALLTDEHILQPFDCGNEVLSNWLRGRAMKNQMLNASRTFVICLEDTLRIVGYYSLATGSVTHAELGRSLRHN
MPNPVPVVLLGRLAVDVCTRGHGFGKWLLSDAIHRVVNLADQVGIKAVMVHAIDDDARAFYERFGFVQSVVAPNTLFYKV
LEHHHHHH
;
;MEINVTAPALLTDEHILQPFDCGNEVLSNWLRGRAMKNQMLNASRTFVICLEDTLRIVGYYSLATGSVTHAELGRSLRHN
MPNPVPVVLLGRLAVDVCTRGHGFGKWLLSDAIHRVVNLADQVGIKAVMVHAIDDDARAFYERFGFVQSVVAPNTLFYKV
LEHHHHHH
;
A ? 
2 'polypeptide(L)' no no MASQRLFVLDNERYDSFITQLEAPVQNAEGRERLMAVKPEWK MASQRLFVLDNERYDSFITQLEAPVQNAEGRERLMAVKPEWK B ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
3 'PHOSPHATE ION' PO4 
4 water           HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   MET n 
1 2   GLU n 
1 3   ILE n 
1 4   ASN n 
1 5   VAL n 
1 6   THR n 
1 7   ALA n 
1 8   PRO n 
1 9   ALA n 
1 10  LEU n 
1 11  LEU n 
1 12  THR n 
1 13  ASP n 
1 14  GLU n 
1 15  HIS n 
1 16  ILE n 
1 17  LEU n 
1 18  GLN n 
1 19  PRO n 
1 20  PHE n 
1 21  ASP n 
1 22  CYS n 
1 23  GLY n 
1 24  ASN n 
1 25  GLU n 
1 26  VAL n 
1 27  LEU n 
1 28  SER n 
1 29  ASN n 
1 30  TRP n 
1 31  LEU n 
1 32  ARG n 
1 33  GLY n 
1 34  ARG n 
1 35  ALA n 
1 36  MET n 
1 37  LYS n 
1 38  ASN n 
1 39  GLN n 
1 40  MET n 
1 41  LEU n 
1 42  ASN n 
1 43  ALA n 
1 44  SER n 
1 45  ARG n 
1 46  THR n 
1 47  PHE n 
1 48  VAL n 
1 49  ILE n 
1 50  CYS n 
1 51  LEU n 
1 52  GLU n 
1 53  ASP n 
1 54  THR n 
1 55  LEU n 
1 56  ARG n 
1 57  ILE n 
1 58  VAL n 
1 59  GLY n 
1 60  TYR n 
1 61  TYR n 
1 62  SER n 
1 63  LEU n 
1 64  ALA n 
1 65  THR n 
1 66  GLY n 
1 67  SER n 
1 68  VAL n 
1 69  THR n 
1 70  HIS n 
1 71  ALA n 
1 72  GLU n 
1 73  LEU n 
1 74  GLY n 
1 75  ARG n 
1 76  SER n 
1 77  LEU n 
1 78  ARG n 
1 79  HIS n 
1 80  ASN n 
1 81  MET n 
1 82  PRO n 
1 83  ASN n 
1 84  PRO n 
1 85  VAL n 
1 86  PRO n 
1 87  VAL n 
1 88  VAL n 
1 89  LEU n 
1 90  LEU n 
1 91  GLY n 
1 92  ARG n 
1 93  LEU n 
1 94  ALA n 
1 95  VAL n 
1 96  ASP n 
1 97  VAL n 
1 98  CYS n 
1 99  THR n 
1 100 ARG n 
1 101 GLY n 
1 102 HIS n 
1 103 GLY n 
1 104 PHE n 
1 105 GLY n 
1 106 LYS n 
1 107 TRP n 
1 108 LEU n 
1 109 LEU n 
1 110 SER n 
1 111 ASP n 
1 112 ALA n 
1 113 ILE n 
1 114 HIS n 
1 115 ARG n 
1 116 VAL n 
1 117 VAL n 
1 118 ASN n 
1 119 LEU n 
1 120 ALA n 
1 121 ASP n 
1 122 GLN n 
1 123 VAL n 
1 124 GLY n 
1 125 ILE n 
1 126 LYS n 
1 127 ALA n 
1 128 VAL n 
1 129 MET n 
1 130 VAL n 
1 131 HIS n 
1 132 ALA n 
1 133 ILE n 
1 134 ASP n 
1 135 ASP n 
1 136 ASP n 
1 137 ALA n 
1 138 ARG n 
1 139 ALA n 
1 140 PHE n 
1 141 TYR n 
1 142 GLU n 
1 143 ARG n 
1 144 PHE n 
1 145 GLY n 
1 146 PHE n 
1 147 VAL n 
1 148 GLN n 
1 149 SER n 
1 150 VAL n 
1 151 VAL n 
1 152 ALA n 
1 153 PRO n 
1 154 ASN n 
1 155 THR n 
1 156 LEU n 
1 157 PHE n 
1 158 TYR n 
1 159 LYS n 
1 160 VAL n 
1 161 LEU n 
1 162 GLU n 
1 163 HIS n 
1 164 HIS n 
1 165 HIS n 
1 166 HIS n 
1 167 HIS n 
1 168 HIS n 
2 1   MET n 
2 2   ALA n 
2 3   SER n 
2 4   GLN n 
2 5   ARG n 
2 6   LEU n 
2 7   PHE n 
2 8   VAL n 
2 9   LEU n 
2 10  ASP n 
2 11  ASN n 
2 12  GLU n 
2 13  ARG n 
2 14  TYR n 
2 15  ASP n 
2 16  SER n 
2 17  PHE n 
2 18  ILE n 
2 19  THR n 
2 20  GLN n 
2 21  LEU n 
2 22  GLU n 
2 23  ALA n 
2 24  PRO n 
2 25  VAL n 
2 26  GLN n 
2 27  ASN n 
2 28  ALA n 
2 29  GLU n 
2 30  GLY n 
2 31  ARG n 
2 32  GLU n 
2 33  ARG n 
2 34  LEU n 
2 35  MET n 
2 36  ALA n 
2 37  VAL n 
2 38  LYS n 
2 39  PRO n 
2 40  GLU n 
2 41  TRP n 
2 42  LYS n 
# 
loop_
_entity_src_gen.entity_id 
_entity_src_gen.pdbx_src_id 
_entity_src_gen.pdbx_alt_source_flag 
_entity_src_gen.pdbx_seq_type 
_entity_src_gen.pdbx_beg_seq_num 
_entity_src_gen.pdbx_end_seq_num 
_entity_src_gen.gene_src_common_name 
_entity_src_gen.gene_src_genus 
_entity_src_gen.pdbx_gene_src_gene 
_entity_src_gen.gene_src_species 
_entity_src_gen.gene_src_strain 
_entity_src_gen.gene_src_tissue 
_entity_src_gen.gene_src_tissue_fraction 
_entity_src_gen.gene_src_details 
_entity_src_gen.pdbx_gene_src_fragment 
_entity_src_gen.pdbx_gene_src_scientific_name 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id 
_entity_src_gen.pdbx_gene_src_variant 
_entity_src_gen.pdbx_gene_src_cell_line 
_entity_src_gen.pdbx_gene_src_atcc 
_entity_src_gen.pdbx_gene_src_organ 
_entity_src_gen.pdbx_gene_src_organelle 
_entity_src_gen.pdbx_gene_src_cell 
_entity_src_gen.pdbx_gene_src_cellular_location 
_entity_src_gen.host_org_common_name 
_entity_src_gen.pdbx_host_org_scientific_name 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id 
_entity_src_gen.host_org_genus 
_entity_src_gen.pdbx_host_org_gene 
_entity_src_gen.pdbx_host_org_organ 
_entity_src_gen.host_org_species 
_entity_src_gen.pdbx_host_org_tissue 
_entity_src_gen.pdbx_host_org_tissue_fraction 
_entity_src_gen.pdbx_host_org_strain 
_entity_src_gen.pdbx_host_org_variant 
_entity_src_gen.pdbx_host_org_cell_line 
_entity_src_gen.pdbx_host_org_atcc 
_entity_src_gen.pdbx_host_org_culture_collection 
_entity_src_gen.pdbx_host_org_cell 
_entity_src_gen.pdbx_host_org_organelle 
_entity_src_gen.pdbx_host_org_cellular_location 
_entity_src_gen.pdbx_host_org_vector_type 
_entity_src_gen.pdbx_host_org_vector 
_entity_src_gen.host_org_details 
_entity_src_gen.expression_system_id 
_entity_src_gen.plasmid_name 
_entity_src_gen.plasmid_details 
_entity_src_gen.pdbx_description 
1 1 sample 'Biological sequence' 1 168 ? ? CBL27_26410 ? ? ? ? ? ? 'Shigella sonnei' 624 ? ? ? ? ? ? ? ? 'Escherichia coli' 562 ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
2 1 sample 'Biological sequence' 1 42  ? ? ?           ? ? ? ? ? ? 'Shigella sonnei' 624 ? ? ? ? ? ? ? ? 'Escherichia coli' 562 ? 
? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID' ? 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE        ? 'C3 H7 N O2 S'   121.158 
GLN 'L-peptide linking' y GLUTAMINE       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID' ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE      ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE          ? 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE      ? 'C5 H11 N O2 S'  149.211 
PHE 'L-peptide linking' y PHENYLALANINE   ? 'C9 H11 N O2'    165.189 
PO4 non-polymer         . 'PHOSPHATE ION' ? 'O4 P -3'        94.971  
PRO 'L-peptide linking' y PROLINE         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE          ? 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   MET 1   1   ?   ?   ?   A . n 
A 1 2   GLU 2   2   2   GLU GLU A . n 
A 1 3   ILE 3   3   3   ILE ILE A . n 
A 1 4   ASN 4   4   4   ASN ASN A . n 
A 1 5   VAL 5   5   5   VAL VAL A . n 
A 1 6   THR 6   6   6   THR THR A . n 
A 1 7   ALA 7   7   7   ALA ALA A . n 
A 1 8   PRO 8   8   8   PRO PRO A . n 
A 1 9   ALA 9   9   9   ALA ALA A . n 
A 1 10  LEU 10  10  10  LEU LEU A . n 
A 1 11  LEU 11  11  11  LEU LEU A . n 
A 1 12  THR 12  12  12  THR THR A . n 
A 1 13  ASP 13  13  13  ASP ASP A . n 
A 1 14  GLU 14  14  14  GLU GLU A . n 
A 1 15  HIS 15  15  15  HIS HIS A . n 
A 1 16  ILE 16  16  16  ILE ILE A . n 
A 1 17  LEU 17  17  17  LEU LEU A . n 
A 1 18  GLN 18  18  18  GLN GLN A . n 
A 1 19  PRO 19  19  19  PRO PRO A . n 
A 1 20  PHE 20  20  20  PHE PHE A . n 
A 1 21  ASP 21  21  21  ASP ASP A . n 
A 1 22  CYS 22  22  22  CYS CYS A . n 
A 1 23  GLY 23  23  23  GLY GLY A . n 
A 1 24  ASN 24  24  24  ASN ASN A . n 
A 1 25  GLU 25  25  25  GLU GLU A . n 
A 1 26  VAL 26  26  26  VAL VAL A . n 
A 1 27  LEU 27  27  27  LEU LEU A . n 
A 1 28  SER 28  28  28  SER SER A . n 
A 1 29  ASN 29  29  29  ASN ASN A . n 
A 1 30  TRP 30  30  30  TRP TRP A . n 
A 1 31  LEU 31  31  31  LEU LEU A . n 
A 1 32  ARG 32  32  32  ARG ARG A . n 
A 1 33  GLY 33  33  33  GLY GLY A . n 
A 1 34  ARG 34  34  34  ARG ARG A . n 
A 1 35  ALA 35  35  35  ALA ALA A . n 
A 1 36  MET 36  36  36  MET MET A . n 
A 1 37  LYS 37  37  37  LYS LYS A . n 
A 1 38  ASN 38  38  38  ASN ASN A . n 
A 1 39  GLN 39  39  39  GLN GLN A . n 
A 1 40  MET 40  40  40  MET MET A . n 
A 1 41  LEU 41  41  41  LEU LEU A . n 
A 1 42  ASN 42  42  42  ASN ASN A . n 
A 1 43  ALA 43  43  43  ALA ALA A . n 
A 1 44  SER 44  44  44  SER SER A . n 
A 1 45  ARG 45  45  45  ARG ARG A . n 
A 1 46  THR 46  46  46  THR THR A . n 
A 1 47  PHE 47  47  47  PHE PHE A . n 
A 1 48  VAL 48  48  48  VAL VAL A . n 
A 1 49  ILE 49  49  49  ILE ILE A . n 
A 1 50  CYS 50  50  50  CYS CYS A . n 
A 1 51  LEU 51  51  51  LEU LEU A . n 
A 1 52  GLU 52  52  52  GLU GLU A . n 
A 1 53  ASP 53  53  53  ASP ASP A . n 
A 1 54  THR 54  54  54  THR THR A . n 
A 1 55  LEU 55  55  55  LEU LEU A . n 
A 1 56  ARG 56  56  56  ARG ARG A . n 
A 1 57  ILE 57  57  57  ILE ILE A . n 
A 1 58  VAL 58  58  58  VAL VAL A . n 
A 1 59  GLY 59  59  59  GLY GLY A . n 
A 1 60  TYR 60  60  60  TYR TYR A . n 
A 1 61  TYR 61  61  61  TYR TYR A . n 
A 1 62  SER 62  62  62  SER SER A . n 
A 1 63  LEU 63  63  63  LEU LEU A . n 
A 1 64  ALA 64  64  64  ALA ALA A . n 
A 1 65  THR 65  65  65  THR THR A . n 
A 1 66  GLY 66  66  66  GLY GLY A . n 
A 1 67  SER 67  67  67  SER SER A . n 
A 1 68  VAL 68  68  68  VAL VAL A . n 
A 1 69  THR 69  69  69  THR THR A . n 
A 1 70  HIS 70  70  70  HIS HIS A . n 
A 1 71  ALA 71  71  71  ALA ALA A . n 
A 1 72  GLU 72  72  72  GLU GLU A . n 
A 1 73  LEU 73  73  ?   ?   ?   A . n 
A 1 74  GLY 74  74  ?   ?   ?   A . n 
A 1 75  ARG 75  75  ?   ?   ?   A . n 
A 1 76  SER 76  76  ?   ?   ?   A . n 
A 1 77  LEU 77  77  ?   ?   ?   A . n 
A 1 78  ARG 78  78  ?   ?   ?   A . n 
A 1 79  HIS 79  79  ?   ?   ?   A . n 
A 1 80  ASN 80  80  ?   ?   ?   A . n 
A 1 81  MET 81  81  ?   ?   ?   A . n 
A 1 82  PRO 82  82  82  PRO PRO A . n 
A 1 83  ASN 83  83  83  ASN ASN A . n 
A 1 84  PRO 84  84  84  PRO PRO A . n 
A 1 85  VAL 85  85  85  VAL VAL A . n 
A 1 86  PRO 86  86  86  PRO PRO A . n 
A 1 87  VAL 87  87  87  VAL VAL A . n 
A 1 88  VAL 88  88  88  VAL VAL A . n 
A 1 89  LEU 89  89  89  LEU LEU A . n 
A 1 90  LEU 90  90  90  LEU LEU A . n 
A 1 91  GLY 91  91  91  GLY GLY A . n 
A 1 92  ARG 92  92  92  ARG ARG A . n 
A 1 93  LEU 93  93  93  LEU LEU A . n 
A 1 94  ALA 94  94  94  ALA ALA A . n 
A 1 95  VAL 95  95  95  VAL VAL A . n 
A 1 96  ASP 96  96  96  ASP ASP A . n 
A 1 97  VAL 97  97  97  VAL VAL A . n 
A 1 98  CYS 98  98  98  CYS CYS A . n 
A 1 99  THR 99  99  99  THR THR A . n 
A 1 100 ARG 100 100 100 ARG ARG A . n 
A 1 101 GLY 101 101 101 GLY GLY A . n 
A 1 102 HIS 102 102 102 HIS HIS A . n 
A 1 103 GLY 103 103 103 GLY GLY A . n 
A 1 104 PHE 104 104 104 PHE PHE A . n 
A 1 105 GLY 105 105 105 GLY GLY A . n 
A 1 106 LYS 106 106 106 LYS LYS A . n 
A 1 107 TRP 107 107 107 TRP TRP A . n 
A 1 108 LEU 108 108 108 LEU LEU A . n 
A 1 109 LEU 109 109 109 LEU LEU A . n 
A 1 110 SER 110 110 110 SER SER A . n 
A 1 111 ASP 111 111 111 ASP ASP A . n 
A 1 112 ALA 112 112 112 ALA ALA A . n 
A 1 113 ILE 113 113 113 ILE ILE A . n 
A 1 114 HIS 114 114 114 HIS HIS A . n 
A 1 115 ARG 115 115 115 ARG ARG A . n 
A 1 116 VAL 116 116 116 VAL VAL A . n 
A 1 117 VAL 117 117 117 VAL VAL A . n 
A 1 118 ASN 118 118 118 ASN ASN A . n 
A 1 119 LEU 119 119 119 LEU LEU A . n 
A 1 120 ALA 120 120 120 ALA ALA A . n 
A 1 121 ASP 121 121 121 ASP ASP A . n 
A 1 122 GLN 122 122 122 GLN GLN A . n 
A 1 123 VAL 123 123 123 VAL VAL A . n 
A 1 124 GLY 124 124 124 GLY GLY A . n 
A 1 125 ILE 125 125 125 ILE ILE A . n 
A 1 126 LYS 126 126 126 LYS LYS A . n 
A 1 127 ALA 127 127 127 ALA ALA A . n 
A 1 128 VAL 128 128 128 VAL VAL A . n 
A 1 129 MET 129 129 129 MET MET A . n 
A 1 130 VAL 130 130 130 VAL VAL A . n 
A 1 131 HIS 131 131 131 HIS HIS A . n 
A 1 132 ALA 132 132 132 ALA ALA A . n 
A 1 133 ILE 133 133 133 ILE ILE A . n 
A 1 134 ASP 134 134 134 ASP ASP A . n 
A 1 135 ASP 135 135 135 ASP ASP A . n 
A 1 136 ASP 136 136 136 ASP ASP A . n 
A 1 137 ALA 137 137 137 ALA ALA A . n 
A 1 138 ARG 138 138 138 ARG ARG A . n 
A 1 139 ALA 139 139 139 ALA ALA A . n 
A 1 140 PHE 140 140 140 PHE PHE A . n 
A 1 141 TYR 141 141 141 TYR TYR A . n 
A 1 142 GLU 142 142 142 GLU GLU A . n 
A 1 143 ARG 143 143 143 ARG ARG A . n 
A 1 144 PHE 144 144 144 PHE PHE A . n 
A 1 145 GLY 145 145 145 GLY GLY A . n 
A 1 146 PHE 146 146 146 PHE PHE A . n 
A 1 147 VAL 147 147 147 VAL VAL A . n 
A 1 148 GLN 148 148 148 GLN GLN A . n 
A 1 149 SER 149 149 149 SER SER A . n 
A 1 150 VAL 150 150 150 VAL VAL A . n 
A 1 151 VAL 151 151 151 VAL VAL A . n 
A 1 152 ALA 152 152 152 ALA ALA A . n 
A 1 153 PRO 153 153 153 PRO PRO A . n 
A 1 154 ASN 154 154 154 ASN ASN A . n 
A 1 155 THR 155 155 155 THR THR A . n 
A 1 156 LEU 156 156 156 LEU LEU A . n 
A 1 157 PHE 157 157 157 PHE PHE A . n 
A 1 158 TYR 158 158 158 TYR TYR A . n 
A 1 159 LYS 159 159 159 LYS LYS A . n 
A 1 160 VAL 160 160 160 VAL VAL A . n 
A 1 161 LEU 161 161 161 LEU LEU A . n 
A 1 162 GLU 162 162 162 GLU GLU A . n 
A 1 163 HIS 163 163 163 HIS HIS A . n 
A 1 164 HIS 164 164 164 HIS HIS A . n 
A 1 165 HIS 165 165 ?   ?   ?   A . n 
A 1 166 HIS 166 166 ?   ?   ?   A . n 
A 1 167 HIS 167 167 ?   ?   ?   A . n 
A 1 168 HIS 168 168 ?   ?   ?   A . n 
B 2 1   MET 1   59  ?   ?   ?   B . n 
B 2 2   ALA 2   60  ?   ?   ?   B . n 
B 2 3   SER 3   61  ?   ?   ?   B . n 
B 2 4   GLN 4   62  62  GLN GLN B . n 
B 2 5   ARG 5   63  63  ARG ARG B . n 
B 2 6   LEU 6   64  64  LEU LEU B . n 
B 2 7   PHE 7   65  65  PHE PHE B . n 
B 2 8   VAL 8   66  66  VAL VAL B . n 
B 2 9   LEU 9   67  67  LEU LEU B . n 
B 2 10  ASP 10  68  68  ASP ASP B . n 
B 2 11  ASN 11  69  69  ASN ASN B . n 
B 2 12  GLU 12  70  70  GLU GLU B . n 
B 2 13  ARG 13  71  71  ARG ARG B . n 
B 2 14  TYR 14  72  72  TYR TYR B . n 
B 2 15  ASP 15  73  73  ASP ASP B . n 
B 2 16  SER 16  74  74  SER SER B . n 
B 2 17  PHE 17  75  75  PHE PHE B . n 
B 2 18  ILE 18  76  76  ILE ILE B . n 
B 2 19  THR 19  77  77  THR THR B . n 
B 2 20  GLN 20  78  78  GLN GLN B . n 
B 2 21  LEU 21  79  79  LEU LEU B . n 
B 2 22  GLU 22  80  80  GLU GLU B . n 
B 2 23  ALA 23  81  81  ALA ALA B . n 
B 2 24  PRO 24  82  82  PRO PRO B . n 
B 2 25  VAL 25  83  83  VAL VAL B . n 
B 2 26  GLN 26  84  84  GLN GLN B . n 
B 2 27  ASN 27  85  85  ASN ASN B . n 
B 2 28  ALA 28  86  86  ALA ALA B . n 
B 2 29  GLU 29  87  87  GLU GLU B . n 
B 2 30  GLY 30  88  88  GLY GLY B . n 
B 2 31  ARG 31  89  89  ARG ARG B . n 
B 2 32  GLU 32  90  90  GLU GLU B . n 
B 2 33  ARG 33  91  91  ARG ARG B . n 
B 2 34  LEU 34  92  92  LEU LEU B . n 
B 2 35  MET 35  93  93  MET MET B . n 
B 2 36  ALA 36  94  94  ALA ALA B . n 
B 2 37  VAL 37  95  95  VAL VAL B . n 
B 2 38  LYS 38  96  96  LYS LYS B . n 
B 2 39  PRO 39  97  97  PRO PRO B . n 
B 2 40  GLU 40  98  98  GLU GLU B . n 
B 2 41  TRP 41  99  99  TRP TRP B . n 
B 2 42  LYS 42  100 100 LYS LYS B . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        PO4 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   PO4 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 3 PO4 1 201 1 PO4 PO4 A . 
D 4 HOH 1 301 2 HOH HOH A . 
D 4 HOH 2 302 1 HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A GLN 18  ? CG  ? A GLN 18  CG  
2  1 Y 1 A GLN 18  ? CD  ? A GLN 18  CD  
3  1 Y 1 A GLN 18  ? OE1 ? A GLN 18  OE1 
4  1 Y 1 A GLN 18  ? NE2 ? A GLN 18  NE2 
5  1 Y 1 A LEU 27  ? CG  ? A LEU 27  CG  
6  1 Y 1 A LEU 27  ? CD1 ? A LEU 27  CD1 
7  1 Y 1 A LEU 27  ? CD2 ? A LEU 27  CD2 
8  1 Y 1 A ARG 32  ? CG  ? A ARG 32  CG  
9  1 Y 1 A ARG 32  ? CD  ? A ARG 32  CD  
10 1 Y 1 A ARG 32  ? NE  ? A ARG 32  NE  
11 1 Y 1 A ARG 32  ? CZ  ? A ARG 32  CZ  
12 1 Y 1 A ARG 32  ? NH1 ? A ARG 32  NH1 
13 1 Y 1 A ARG 32  ? NH2 ? A ARG 32  NH2 
14 1 Y 1 A ARG 34  ? CG  ? A ARG 34  CG  
15 1 Y 1 A ARG 34  ? CD  ? A ARG 34  CD  
16 1 Y 1 A ARG 34  ? NE  ? A ARG 34  NE  
17 1 Y 1 A ARG 34  ? CZ  ? A ARG 34  CZ  
18 1 Y 1 A ARG 34  ? NH1 ? A ARG 34  NH1 
19 1 Y 1 A ARG 34  ? NH2 ? A ARG 34  NH2 
20 1 Y 1 A MET 36  ? CG  ? A MET 36  CG  
21 1 Y 1 A MET 36  ? SD  ? A MET 36  SD  
22 1 Y 1 A MET 36  ? CE  ? A MET 36  CE  
23 1 Y 1 A LEU 51  ? CG  ? A LEU 51  CG  
24 1 Y 1 A LEU 51  ? CD1 ? A LEU 51  CD1 
25 1 Y 1 A LEU 51  ? CD2 ? A LEU 51  CD2 
26 1 Y 1 A ARG 100 ? CG  ? A ARG 100 CG  
27 1 Y 1 A ARG 100 ? CD  ? A ARG 100 CD  
28 1 Y 1 A ARG 100 ? NE  ? A ARG 100 NE  
29 1 Y 1 A ARG 100 ? CZ  ? A ARG 100 CZ  
30 1 Y 1 A ARG 100 ? NH1 ? A ARG 100 NH1 
31 1 Y 1 A ARG 100 ? NH2 ? A ARG 100 NH2 
32 1 Y 1 A LYS 106 ? CG  ? A LYS 106 CG  
33 1 Y 1 A LYS 106 ? CD  ? A LYS 106 CD  
34 1 Y 1 A LYS 106 ? CE  ? A LYS 106 CE  
35 1 Y 1 A LYS 106 ? NZ  ? A LYS 106 NZ  
36 1 Y 1 A HIS 131 ? CG  ? A HIS 131 CG  
37 1 Y 1 A HIS 131 ? ND1 ? A HIS 131 ND1 
38 1 Y 1 A HIS 131 ? CD2 ? A HIS 131 CD2 
39 1 Y 1 A HIS 131 ? CE1 ? A HIS 131 CE1 
40 1 Y 1 A HIS 131 ? NE2 ? A HIS 131 NE2 
41 1 Y 1 A ILE 133 ? CG1 ? A ILE 133 CG1 
42 1 Y 1 A ILE 133 ? CG2 ? A ILE 133 CG2 
43 1 Y 1 A ILE 133 ? CD1 ? A ILE 133 CD1 
44 1 Y 1 A TYR 141 ? OH  ? A TYR 141 OH  
45 1 Y 1 B LYS 96  ? CG  ? B LYS 38  CG  
46 1 Y 1 B LYS 96  ? CD  ? B LYS 38  CD  
47 1 Y 1 B LYS 96  ? CE  ? B LYS 38  CE  
48 1 Y 1 B LYS 96  ? NZ  ? B LYS 38  NZ  
49 1 Y 1 B GLU 98  ? CG  ? B GLU 40  CG  
50 1 Y 1 B GLU 98  ? CD  ? B GLU 40  CD  
51 1 Y 1 B GLU 98  ? OE1 ? B GLU 40  OE1 
52 1 Y 1 B GLU 98  ? OE2 ? B GLU 40  OE2 
53 1 Y 1 B LYS 100 ? CG  ? B LYS 42  CG  
54 1 Y 1 B LYS 100 ? CD  ? B LYS 42  CD  
55 1 Y 1 B LYS 100 ? CE  ? B LYS 42  CE  
56 1 Y 1 B LYS 100 ? NZ  ? B LYS 42  NZ  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX  ? ? ? 1.20.1_4487 1 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS     ? ? ? .           2 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? Aimless ? ? ? .           3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER  ? ? ? .           4 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  120.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9ILS 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     78.572 
_cell.length_a_esd                 ? 
_cell.length_b                     78.572 
_cell.length_b_esd                 ? 
_cell.length_c                     131.937 
_cell.length_c_esd                 ? 
_cell.volume                       705395.772 
_cell.volume_esd                   ? 
_cell.Z_PDB                        12 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9ILS 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                179 
_symmetry.space_group_name_Hall            'P 65 2 (x,y,z+1/12)' 
_symmetry.space_group_name_H-M             'P 65 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9ILS 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.47 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          50.11 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              ? 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    '1.4-1.9 M KH2PO4 and 0.1 M HEPES pH 7.0.' 
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            298 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS3 6M' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2020-03-27 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.979 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SSRF BEAMLINE BL19U1' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        0.979 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   BL19U1 
_diffrn_source.pdbx_synchrotron_site       SSRF 
# 
_reflns.B_iso_Wilson_estimate                          80.80 
_reflns.entry_id                                       9ILS 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.75 
_reflns.d_resolution_low                               50 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     6761 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           100 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                36.5 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          43.5 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                ? 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   1.00 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              0.132 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.75 
_reflns_shell.d_res_low                                     2.85 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           3 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             658 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               ? 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.87 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  1.41 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               79.50 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9ILS 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.75 
_refine.ls_d_res_low                             29.68 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     6362 
_refine.ls_number_reflns_R_free                  308 
_refine.ls_number_reflns_R_work                  6054 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    94.74 
_refine.ls_percent_reflns_R_free                 4.84 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2501 
_refine.ls_R_factor_R_free                       0.2770 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2487 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.38 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      7AK8 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 33.6084 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.3331 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.75 
_refine_hist.d_res_low                        29.68 
_refine_hist.number_atoms_solvent             2 
_refine_hist.number_atoms_total               1484 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        1477 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         5 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0096 ? 1512 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 1.1621 ? 2062 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0636 ? 239  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0106 ? 268  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 6.1705 ? 204  ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.75 3.47  . . 151 2829 91.52 . . . . 0.2758 . . . . . . . . . . . 0.3552 
'X-RAY DIFFRACTION' 3.47 29.68 . . 157 3225 97.77 . . . . 0.2420 . . . . . . . . . . . 0.2575 
# 
_struct.entry_id                     9ILS 
_struct.title                        'The GmvT toxin in complex with the C-terminal fragment of its antitoxin' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9ILS 
_struct_keywords.text            'toxin-antitoxin system, GNAT, acetylation, AcCoA, GmvAT, TOXIN' 
_struct_keywords.pdbx_keywords   TOXIN 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 3 ? 
D N N 4 ? 
# 
loop_
_struct_ref.id 
_struct_ref.db_name 
_struct_ref.db_code 
_struct_ref.pdbx_db_accession 
_struct_ref.pdbx_db_isoform 
_struct_ref.entity_id 
_struct_ref.pdbx_seq_one_letter_code 
_struct_ref.pdbx_align_begin 
1 UNP A0A200L144_SHISO A0A200L144 ? 1 
;MEINVTAPALLTDEHILQPFDCGNEVLSNWLRGRAMKNQMLNASRTFVICLEDTLRIVGYYSLATGSVTHAELGRSLRHN
MPNPVPVVLLGRLAVDVCTQGHGFGKWLLSDAIHRVVNLADQVGIKAVMVHAIDDDARAFYERFGFVQSVVAPNTLFYKV

;
1 
2 PDB 9ILS             9ILS       ? 2 ? 1 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9ILS A 1 ? 160 ? A0A200L144 1  ? 160 ? 1  160 
2 2 9ILS B 1 ? 42  ? 9ILS       59 ? 100 ? 59 100 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9ILS ARG A 100 ? UNP A0A200L144 GLN 100 'engineered mutation' 100 1 
1 9ILS LEU A 161 ? UNP A0A200L144 ?   ?   'expression tag'      161 2 
1 9ILS GLU A 162 ? UNP A0A200L144 ?   ?   'expression tag'      162 3 
1 9ILS HIS A 163 ? UNP A0A200L144 ?   ?   'expression tag'      163 4 
1 9ILS HIS A 164 ? UNP A0A200L144 ?   ?   'expression tag'      164 5 
1 9ILS HIS A 165 ? UNP A0A200L144 ?   ?   'expression tag'      165 6 
1 9ILS HIS A 166 ? UNP A0A200L144 ?   ?   'expression tag'      166 7 
1 9ILS HIS A 167 ? UNP A0A200L144 ?   ?   'expression tag'      167 8 
1 9ILS HIS A 168 ? UNP A0A200L144 ?   ?   'expression tag'      168 9 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_and_software_defined_assembly 
_pdbx_struct_assembly.method_details       PISA 
_pdbx_struct_assembly.oligomeric_details   dimeric 
_pdbx_struct_assembly.oligomeric_count     2 
# 
loop_
_pdbx_struct_assembly_prop.biol_id 
_pdbx_struct_assembly_prop.type 
_pdbx_struct_assembly_prop.value 
_pdbx_struct_assembly_prop.details 
1 'ABSA (A^2)' 3510  ? 
1 MORE         -30   ? 
1 'SSA (A^2)'  10050 ? 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D 
# 
_pdbx_struct_assembly_auth_evidence.id                     1 
_pdbx_struct_assembly_auth_evidence.assembly_id            1 
_pdbx_struct_assembly_auth_evidence.experimental_support   'gel filtration' 
_pdbx_struct_assembly_auth_evidence.details                ? 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1 AA1 ASN A 24  ? GLY A 33  ? ASN A 24  GLY A 33  1 ? 10 
HELX_P HELX_P2 AA2 GLY A 33  ? ASN A 42  ? GLY A 33  ASN A 42  1 ? 10 
HELX_P HELX_P3 AA3 GLY A 103 ? ALA A 120 ? GLY A 103 ALA A 120 1 ? 18 
HELX_P HELX_P4 AA4 ASP A 134 ? ARG A 143 ? ASP A 134 ARG A 143 1 ? 10 
HELX_P HELX_P5 AA5 ASP B 10  ? ALA B 23  ? ASP B 68  ALA B 81  1 ? 14 
HELX_P HELX_P6 AA6 ASN B 27  ? VAL B 37  ? ASN B 85  VAL B 95  1 ? 11 
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 7 ? 
AA2 ? 4 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? anti-parallel 
AA1 4 5 ? parallel      
AA1 5 6 ? anti-parallel 
AA1 6 7 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? parallel      
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 9   ? LEU A 10  ? ALA A 9   LEU A 10  
AA1 2 ARG A 45  ? CYS A 50  ? ARG A 45  CYS A 50  
AA1 3 ILE A 57  ? HIS A 70  ? ILE A 57  HIS A 70  
AA1 4 VAL A 85  ? VAL A 95  ? VAL A 85  VAL A 95  
AA1 5 ALA A 127 ? HIS A 131 ? ALA A 127 HIS A 131 
AA1 6 THR A 155 ? LYS A 159 ? THR A 155 LYS A 159 
AA1 7 VAL A 147 ? GLN A 148 ? VAL A 147 GLN A 148 
AA2 1 ALA A 9   ? LEU A 10  ? ALA A 9   LEU A 10  
AA2 2 ARG A 45  ? CYS A 50  ? ARG A 45  CYS A 50  
AA2 3 ILE A 57  ? HIS A 70  ? ILE A 57  HIS A 70  
AA2 4 LEU B 6   ? LEU B 9   ? LEU B 64  LEU B 67  
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ALA A 9   ? N ALA A 9   O VAL A 48  ? O VAL A 48  
AA1 2 3 N PHE A 47  ? N PHE A 47  O TYR A 61  ? O TYR A 61  
AA1 3 4 N ALA A 64  ? N ALA A 64  O LEU A 89  ? O LEU A 89  
AA1 4 5 N LEU A 90  ? N LEU A 90  O MET A 129 ? O MET A 129 
AA1 5 6 N VAL A 130 ? N VAL A 130 O LEU A 156 ? O LEU A 156 
AA1 6 7 O PHE A 157 ? O PHE A 157 N VAL A 147 ? N VAL A 147 
AA2 1 2 N ALA A 9   ? N ALA A 9   O VAL A 48  ? O VAL A 48  
AA2 2 3 N PHE A 47  ? N PHE A 47  O TYR A 61  ? O TYR A 61  
AA2 3 4 N SER A 67  ? N SER A 67  O PHE B 7   ? O PHE B 65  
# 
_pdbx_entry_details.entry_id                   9ILS 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   NH2 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   ARG 
_pdbx_validate_close_contact.auth_seq_id_1    138 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   OE1 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   GLN 
_pdbx_validate_close_contact.auth_seq_id_2    148 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.19 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    PRO 
_pdbx_validate_symm_contact.auth_seq_id_1     84 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    NH2 
_pdbx_validate_symm_contact.auth_asym_id_2    B 
_pdbx_validate_symm_contact.auth_comp_id_2    ARG 
_pdbx_validate_symm_contact.auth_seq_id_2     63 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   9_555 
_pdbx_validate_symm_contact.dist              2.19 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 THR A 12  ? ? -104.28 -163.13 
2 1 ASN A 42  ? ? 68.81   63.85   
3 1 ARG A 100 ? ? -115.36 -85.49  
4 1 ILE A 133 ? ? -57.48  -84.00  
5 1 VAL B 95  ? ? -46.27  95.48   
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1  x,y,z          
2  x-y,x,z+5/6    
3  y,-x+y,z+1/6   
4  -y,x-y,z+2/3   
5  -x+y,-x,z+1/3  
6  x-y,-y,-z      
7  -x,-x+y,-z+1/3 
8  -x,-y,z+1/2    
9  y,x,-z+2/3     
10 -y,-x,-z+1/6   
11 -x+y,y,-z+1/2  
12 x,x-y,-z+5/6   
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A MET 1   ? A MET 1   
2  1 Y 1 A LEU 73  ? A LEU 73  
3  1 Y 1 A GLY 74  ? A GLY 74  
4  1 Y 1 A ARG 75  ? A ARG 75  
5  1 Y 1 A SER 76  ? A SER 76  
6  1 Y 1 A LEU 77  ? A LEU 77  
7  1 Y 1 A ARG 78  ? A ARG 78  
8  1 Y 1 A HIS 79  ? A HIS 79  
9  1 Y 1 A ASN 80  ? A ASN 80  
10 1 Y 1 A MET 81  ? A MET 81  
11 1 Y 1 A HIS 165 ? A HIS 165 
12 1 Y 1 A HIS 166 ? A HIS 166 
13 1 Y 1 A HIS 167 ? A HIS 167 
14 1 Y 1 A HIS 168 ? A HIS 168 
15 1 Y 1 B MET 59  ? B MET 1   
16 1 Y 1 B ALA 60  ? B ALA 2   
17 1 Y 1 B SER 61  ? B SER 3   
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N N N 1   
ALA CA   C N S 2   
ALA C    C N N 3   
ALA O    O N N 4   
ALA CB   C N N 5   
ALA OXT  O N N 6   
ALA H    H N N 7   
ALA H2   H N N 8   
ALA HA   H N N 9   
ALA HB1  H N N 10  
ALA HB2  H N N 11  
ALA HB3  H N N 12  
ALA HXT  H N N 13  
ARG N    N N N 14  
ARG CA   C N S 15  
ARG C    C N N 16  
ARG O    O N N 17  
ARG CB   C N N 18  
ARG CG   C N N 19  
ARG CD   C N N 20  
ARG NE   N N N 21  
ARG CZ   C N N 22  
ARG NH1  N N N 23  
ARG NH2  N N N 24  
ARG OXT  O N N 25  
ARG H    H N N 26  
ARG H2   H N N 27  
ARG HA   H N N 28  
ARG HB2  H N N 29  
ARG HB3  H N N 30  
ARG HG2  H N N 31  
ARG HG3  H N N 32  
ARG HD2  H N N 33  
ARG HD3  H N N 34  
ARG HE   H N N 35  
ARG HH11 H N N 36  
ARG HH12 H N N 37  
ARG HH21 H N N 38  
ARG HH22 H N N 39  
ARG HXT  H N N 40  
ASN N    N N N 41  
ASN CA   C N S 42  
ASN C    C N N 43  
ASN O    O N N 44  
ASN CB   C N N 45  
ASN CG   C N N 46  
ASN OD1  O N N 47  
ASN ND2  N N N 48  
ASN OXT  O N N 49  
ASN H    H N N 50  
ASN H2   H N N 51  
ASN HA   H N N 52  
ASN HB2  H N N 53  
ASN HB3  H N N 54  
ASN HD21 H N N 55  
ASN HD22 H N N 56  
ASN HXT  H N N 57  
ASP N    N N N 58  
ASP CA   C N S 59  
ASP C    C N N 60  
ASP O    O N N 61  
ASP CB   C N N 62  
ASP CG   C N N 63  
ASP OD1  O N N 64  
ASP OD2  O N N 65  
ASP OXT  O N N 66  
ASP H    H N N 67  
ASP H2   H N N 68  
ASP HA   H N N 69  
ASP HB2  H N N 70  
ASP HB3  H N N 71  
ASP HD2  H N N 72  
ASP HXT  H N N 73  
CYS N    N N N 74  
CYS CA   C N R 75  
CYS C    C N N 76  
CYS O    O N N 77  
CYS CB   C N N 78  
CYS SG   S N N 79  
CYS OXT  O N N 80  
CYS H    H N N 81  
CYS H2   H N N 82  
CYS HA   H N N 83  
CYS HB2  H N N 84  
CYS HB3  H N N 85  
CYS HG   H N N 86  
CYS HXT  H N N 87  
GLN N    N N N 88  
GLN CA   C N S 89  
GLN C    C N N 90  
GLN O    O N N 91  
GLN CB   C N N 92  
GLN CG   C N N 93  
GLN CD   C N N 94  
GLN OE1  O N N 95  
GLN NE2  N N N 96  
GLN OXT  O N N 97  
GLN H    H N N 98  
GLN H2   H N N 99  
GLN HA   H N N 100 
GLN HB2  H N N 101 
GLN HB3  H N N 102 
GLN HG2  H N N 103 
GLN HG3  H N N 104 
GLN HE21 H N N 105 
GLN HE22 H N N 106 
GLN HXT  H N N 107 
GLU N    N N N 108 
GLU CA   C N S 109 
GLU C    C N N 110 
GLU O    O N N 111 
GLU CB   C N N 112 
GLU CG   C N N 113 
GLU CD   C N N 114 
GLU OE1  O N N 115 
GLU OE2  O N N 116 
GLU OXT  O N N 117 
GLU H    H N N 118 
GLU H2   H N N 119 
GLU HA   H N N 120 
GLU HB2  H N N 121 
GLU HB3  H N N 122 
GLU HG2  H N N 123 
GLU HG3  H N N 124 
GLU HE2  H N N 125 
GLU HXT  H N N 126 
GLY N    N N N 127 
GLY CA   C N N 128 
GLY C    C N N 129 
GLY O    O N N 130 
GLY OXT  O N N 131 
GLY H    H N N 132 
GLY H2   H N N 133 
GLY HA2  H N N 134 
GLY HA3  H N N 135 
GLY HXT  H N N 136 
HIS N    N N N 137 
HIS CA   C N S 138 
HIS C    C N N 139 
HIS O    O N N 140 
HIS CB   C N N 141 
HIS CG   C Y N 142 
HIS ND1  N Y N 143 
HIS CD2  C Y N 144 
HIS CE1  C Y N 145 
HIS NE2  N Y N 146 
HIS OXT  O N N 147 
HIS H    H N N 148 
HIS H2   H N N 149 
HIS HA   H N N 150 
HIS HB2  H N N 151 
HIS HB3  H N N 152 
HIS HD1  H N N 153 
HIS HD2  H N N 154 
HIS HE1  H N N 155 
HIS HE2  H N N 156 
HIS HXT  H N N 157 
HOH O    O N N 158 
HOH H1   H N N 159 
HOH H2   H N N 160 
ILE N    N N N 161 
ILE CA   C N S 162 
ILE C    C N N 163 
ILE O    O N N 164 
ILE CB   C N S 165 
ILE CG1  C N N 166 
ILE CG2  C N N 167 
ILE CD1  C N N 168 
ILE OXT  O N N 169 
ILE H    H N N 170 
ILE H2   H N N 171 
ILE HA   H N N 172 
ILE HB   H N N 173 
ILE HG12 H N N 174 
ILE HG13 H N N 175 
ILE HG21 H N N 176 
ILE HG22 H N N 177 
ILE HG23 H N N 178 
ILE HD11 H N N 179 
ILE HD12 H N N 180 
ILE HD13 H N N 181 
ILE HXT  H N N 182 
LEU N    N N N 183 
LEU CA   C N S 184 
LEU C    C N N 185 
LEU O    O N N 186 
LEU CB   C N N 187 
LEU CG   C N N 188 
LEU CD1  C N N 189 
LEU CD2  C N N 190 
LEU OXT  O N N 191 
LEU H    H N N 192 
LEU H2   H N N 193 
LEU HA   H N N 194 
LEU HB2  H N N 195 
LEU HB3  H N N 196 
LEU HG   H N N 197 
LEU HD11 H N N 198 
LEU HD12 H N N 199 
LEU HD13 H N N 200 
LEU HD21 H N N 201 
LEU HD22 H N N 202 
LEU HD23 H N N 203 
LEU HXT  H N N 204 
LYS N    N N N 205 
LYS CA   C N S 206 
LYS C    C N N 207 
LYS O    O N N 208 
LYS CB   C N N 209 
LYS CG   C N N 210 
LYS CD   C N N 211 
LYS CE   C N N 212 
LYS NZ   N N N 213 
LYS OXT  O N N 214 
LYS H    H N N 215 
LYS H2   H N N 216 
LYS HA   H N N 217 
LYS HB2  H N N 218 
LYS HB3  H N N 219 
LYS HG2  H N N 220 
LYS HG3  H N N 221 
LYS HD2  H N N 222 
LYS HD3  H N N 223 
LYS HE2  H N N 224 
LYS HE3  H N N 225 
LYS HZ1  H N N 226 
LYS HZ2  H N N 227 
LYS HZ3  H N N 228 
LYS HXT  H N N 229 
MET N    N N N 230 
MET CA   C N S 231 
MET C    C N N 232 
MET O    O N N 233 
MET CB   C N N 234 
MET CG   C N N 235 
MET SD   S N N 236 
MET CE   C N N 237 
MET OXT  O N N 238 
MET H    H N N 239 
MET H2   H N N 240 
MET HA   H N N 241 
MET HB2  H N N 242 
MET HB3  H N N 243 
MET HG2  H N N 244 
MET HG3  H N N 245 
MET HE1  H N N 246 
MET HE2  H N N 247 
MET HE3  H N N 248 
MET HXT  H N N 249 
PHE N    N N N 250 
PHE CA   C N S 251 
PHE C    C N N 252 
PHE O    O N N 253 
PHE CB   C N N 254 
PHE CG   C Y N 255 
PHE CD1  C Y N 256 
PHE CD2  C Y N 257 
PHE CE1  C Y N 258 
PHE CE2  C Y N 259 
PHE CZ   C Y N 260 
PHE OXT  O N N 261 
PHE H    H N N 262 
PHE H2   H N N 263 
PHE HA   H N N 264 
PHE HB2  H N N 265 
PHE HB3  H N N 266 
PHE HD1  H N N 267 
PHE HD2  H N N 268 
PHE HE1  H N N 269 
PHE HE2  H N N 270 
PHE HZ   H N N 271 
PHE HXT  H N N 272 
PO4 P    P N N 273 
PO4 O1   O N N 274 
PO4 O2   O N N 275 
PO4 O3   O N N 276 
PO4 O4   O N N 277 
PRO N    N N N 278 
PRO CA   C N S 279 
PRO C    C N N 280 
PRO O    O N N 281 
PRO CB   C N N 282 
PRO CG   C N N 283 
PRO CD   C N N 284 
PRO OXT  O N N 285 
PRO H    H N N 286 
PRO HA   H N N 287 
PRO HB2  H N N 288 
PRO HB3  H N N 289 
PRO HG2  H N N 290 
PRO HG3  H N N 291 
PRO HD2  H N N 292 
PRO HD3  H N N 293 
PRO HXT  H N N 294 
SER N    N N N 295 
SER CA   C N S 296 
SER C    C N N 297 
SER O    O N N 298 
SER CB   C N N 299 
SER OG   O N N 300 
SER OXT  O N N 301 
SER H    H N N 302 
SER H2   H N N 303 
SER HA   H N N 304 
SER HB2  H N N 305 
SER HB3  H N N 306 
SER HG   H N N 307 
SER HXT  H N N 308 
THR N    N N N 309 
THR CA   C N S 310 
THR C    C N N 311 
THR O    O N N 312 
THR CB   C N R 313 
THR OG1  O N N 314 
THR CG2  C N N 315 
THR OXT  O N N 316 
THR H    H N N 317 
THR H2   H N N 318 
THR HA   H N N 319 
THR HB   H N N 320 
THR HG1  H N N 321 
THR HG21 H N N 322 
THR HG22 H N N 323 
THR HG23 H N N 324 
THR HXT  H N N 325 
TRP N    N N N 326 
TRP CA   C N S 327 
TRP C    C N N 328 
TRP O    O N N 329 
TRP CB   C N N 330 
TRP CG   C Y N 331 
TRP CD1  C Y N 332 
TRP CD2  C Y N 333 
TRP NE1  N Y N 334 
TRP CE2  C Y N 335 
TRP CE3  C Y N 336 
TRP CZ2  C Y N 337 
TRP CZ3  C Y N 338 
TRP CH2  C Y N 339 
TRP OXT  O N N 340 
TRP H    H N N 341 
TRP H2   H N N 342 
TRP HA   H N N 343 
TRP HB2  H N N 344 
TRP HB3  H N N 345 
TRP HD1  H N N 346 
TRP HE1  H N N 347 
TRP HE3  H N N 348 
TRP HZ2  H N N 349 
TRP HZ3  H N N 350 
TRP HH2  H N N 351 
TRP HXT  H N N 352 
TYR N    N N N 353 
TYR CA   C N S 354 
TYR C    C N N 355 
TYR O    O N N 356 
TYR CB   C N N 357 
TYR CG   C Y N 358 
TYR CD1  C Y N 359 
TYR CD2  C Y N 360 
TYR CE1  C Y N 361 
TYR CE2  C Y N 362 
TYR CZ   C Y N 363 
TYR OH   O N N 364 
TYR OXT  O N N 365 
TYR H    H N N 366 
TYR H2   H N N 367 
TYR HA   H N N 368 
TYR HB2  H N N 369 
TYR HB3  H N N 370 
TYR HD1  H N N 371 
TYR HD2  H N N 372 
TYR HE1  H N N 373 
TYR HE2  H N N 374 
TYR HH   H N N 375 
TYR HXT  H N N 376 
VAL N    N N N 377 
VAL CA   C N S 378 
VAL C    C N N 379 
VAL O    O N N 380 
VAL CB   C N N 381 
VAL CG1  C N N 382 
VAL CG2  C N N 383 
VAL OXT  O N N 384 
VAL H    H N N 385 
VAL H2   H N N 386 
VAL HA   H N N 387 
VAL HB   H N N 388 
VAL HG11 H N N 389 
VAL HG12 H N N 390 
VAL HG13 H N N 391 
VAL HG21 H N N 392 
VAL HG22 H N N 393 
VAL HG23 H N N 394 
VAL HXT  H N N 395 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
GLN N   CA   sing N N 83  
GLN N   H    sing N N 84  
GLN N   H2   sing N N 85  
GLN CA  C    sing N N 86  
GLN CA  CB   sing N N 87  
GLN CA  HA   sing N N 88  
GLN C   O    doub N N 89  
GLN C   OXT  sing N N 90  
GLN CB  CG   sing N N 91  
GLN CB  HB2  sing N N 92  
GLN CB  HB3  sing N N 93  
GLN CG  CD   sing N N 94  
GLN CG  HG2  sing N N 95  
GLN CG  HG3  sing N N 96  
GLN CD  OE1  doub N N 97  
GLN CD  NE2  sing N N 98  
GLN NE2 HE21 sing N N 99  
GLN NE2 HE22 sing N N 100 
GLN OXT HXT  sing N N 101 
GLU N   CA   sing N N 102 
GLU N   H    sing N N 103 
GLU N   H2   sing N N 104 
GLU CA  C    sing N N 105 
GLU CA  CB   sing N N 106 
GLU CA  HA   sing N N 107 
GLU C   O    doub N N 108 
GLU C   OXT  sing N N 109 
GLU CB  CG   sing N N 110 
GLU CB  HB2  sing N N 111 
GLU CB  HB3  sing N N 112 
GLU CG  CD   sing N N 113 
GLU CG  HG2  sing N N 114 
GLU CG  HG3  sing N N 115 
GLU CD  OE1  doub N N 116 
GLU CD  OE2  sing N N 117 
GLU OE2 HE2  sing N N 118 
GLU OXT HXT  sing N N 119 
GLY N   CA   sing N N 120 
GLY N   H    sing N N 121 
GLY N   H2   sing N N 122 
GLY CA  C    sing N N 123 
GLY CA  HA2  sing N N 124 
GLY CA  HA3  sing N N 125 
GLY C   O    doub N N 126 
GLY C   OXT  sing N N 127 
GLY OXT HXT  sing N N 128 
HIS N   CA   sing N N 129 
HIS N   H    sing N N 130 
HIS N   H2   sing N N 131 
HIS CA  C    sing N N 132 
HIS CA  CB   sing N N 133 
HIS CA  HA   sing N N 134 
HIS C   O    doub N N 135 
HIS C   OXT  sing N N 136 
HIS CB  CG   sing N N 137 
HIS CB  HB2  sing N N 138 
HIS CB  HB3  sing N N 139 
HIS CG  ND1  sing Y N 140 
HIS CG  CD2  doub Y N 141 
HIS ND1 CE1  doub Y N 142 
HIS ND1 HD1  sing N N 143 
HIS CD2 NE2  sing Y N 144 
HIS CD2 HD2  sing N N 145 
HIS CE1 NE2  sing Y N 146 
HIS CE1 HE1  sing N N 147 
HIS NE2 HE2  sing N N 148 
HIS OXT HXT  sing N N 149 
HOH O   H1   sing N N 150 
HOH O   H2   sing N N 151 
ILE N   CA   sing N N 152 
ILE N   H    sing N N 153 
ILE N   H2   sing N N 154 
ILE CA  C    sing N N 155 
ILE CA  CB   sing N N 156 
ILE CA  HA   sing N N 157 
ILE C   O    doub N N 158 
ILE C   OXT  sing N N 159 
ILE CB  CG1  sing N N 160 
ILE CB  CG2  sing N N 161 
ILE CB  HB   sing N N 162 
ILE CG1 CD1  sing N N 163 
ILE CG1 HG12 sing N N 164 
ILE CG1 HG13 sing N N 165 
ILE CG2 HG21 sing N N 166 
ILE CG2 HG22 sing N N 167 
ILE CG2 HG23 sing N N 168 
ILE CD1 HD11 sing N N 169 
ILE CD1 HD12 sing N N 170 
ILE CD1 HD13 sing N N 171 
ILE OXT HXT  sing N N 172 
LEU N   CA   sing N N 173 
LEU N   H    sing N N 174 
LEU N   H2   sing N N 175 
LEU CA  C    sing N N 176 
LEU CA  CB   sing N N 177 
LEU CA  HA   sing N N 178 
LEU C   O    doub N N 179 
LEU C   OXT  sing N N 180 
LEU CB  CG   sing N N 181 
LEU CB  HB2  sing N N 182 
LEU CB  HB3  sing N N 183 
LEU CG  CD1  sing N N 184 
LEU CG  CD2  sing N N 185 
LEU CG  HG   sing N N 186 
LEU CD1 HD11 sing N N 187 
LEU CD1 HD12 sing N N 188 
LEU CD1 HD13 sing N N 189 
LEU CD2 HD21 sing N N 190 
LEU CD2 HD22 sing N N 191 
LEU CD2 HD23 sing N N 192 
LEU OXT HXT  sing N N 193 
LYS N   CA   sing N N 194 
LYS N   H    sing N N 195 
LYS N   H2   sing N N 196 
LYS CA  C    sing N N 197 
LYS CA  CB   sing N N 198 
LYS CA  HA   sing N N 199 
LYS C   O    doub N N 200 
LYS C   OXT  sing N N 201 
LYS CB  CG   sing N N 202 
LYS CB  HB2  sing N N 203 
LYS CB  HB3  sing N N 204 
LYS CG  CD   sing N N 205 
LYS CG  HG2  sing N N 206 
LYS CG  HG3  sing N N 207 
LYS CD  CE   sing N N 208 
LYS CD  HD2  sing N N 209 
LYS CD  HD3  sing N N 210 
LYS CE  NZ   sing N N 211 
LYS CE  HE2  sing N N 212 
LYS CE  HE3  sing N N 213 
LYS NZ  HZ1  sing N N 214 
LYS NZ  HZ2  sing N N 215 
LYS NZ  HZ3  sing N N 216 
LYS OXT HXT  sing N N 217 
MET N   CA   sing N N 218 
MET N   H    sing N N 219 
MET N   H2   sing N N 220 
MET CA  C    sing N N 221 
MET CA  CB   sing N N 222 
MET CA  HA   sing N N 223 
MET C   O    doub N N 224 
MET C   OXT  sing N N 225 
MET CB  CG   sing N N 226 
MET CB  HB2  sing N N 227 
MET CB  HB3  sing N N 228 
MET CG  SD   sing N N 229 
MET CG  HG2  sing N N 230 
MET CG  HG3  sing N N 231 
MET SD  CE   sing N N 232 
MET CE  HE1  sing N N 233 
MET CE  HE2  sing N N 234 
MET CE  HE3  sing N N 235 
MET OXT HXT  sing N N 236 
PHE N   CA   sing N N 237 
PHE N   H    sing N N 238 
PHE N   H2   sing N N 239 
PHE CA  C    sing N N 240 
PHE CA  CB   sing N N 241 
PHE CA  HA   sing N N 242 
PHE C   O    doub N N 243 
PHE C   OXT  sing N N 244 
PHE CB  CG   sing N N 245 
PHE CB  HB2  sing N N 246 
PHE CB  HB3  sing N N 247 
PHE CG  CD1  doub Y N 248 
PHE CG  CD2  sing Y N 249 
PHE CD1 CE1  sing Y N 250 
PHE CD1 HD1  sing N N 251 
PHE CD2 CE2  doub Y N 252 
PHE CD2 HD2  sing N N 253 
PHE CE1 CZ   doub Y N 254 
PHE CE1 HE1  sing N N 255 
PHE CE2 CZ   sing Y N 256 
PHE CE2 HE2  sing N N 257 
PHE CZ  HZ   sing N N 258 
PHE OXT HXT  sing N N 259 
PO4 P   O1   doub N N 260 
PO4 P   O2   sing N N 261 
PO4 P   O3   sing N N 262 
PO4 P   O4   sing N N 263 
PRO N   CA   sing N N 264 
PRO N   CD   sing N N 265 
PRO N   H    sing N N 266 
PRO CA  C    sing N N 267 
PRO CA  CB   sing N N 268 
PRO CA  HA   sing N N 269 
PRO C   O    doub N N 270 
PRO C   OXT  sing N N 271 
PRO CB  CG   sing N N 272 
PRO CB  HB2  sing N N 273 
PRO CB  HB3  sing N N 274 
PRO CG  CD   sing N N 275 
PRO CG  HG2  sing N N 276 
PRO CG  HG3  sing N N 277 
PRO CD  HD2  sing N N 278 
PRO CD  HD3  sing N N 279 
PRO OXT HXT  sing N N 280 
SER N   CA   sing N N 281 
SER N   H    sing N N 282 
SER N   H2   sing N N 283 
SER CA  C    sing N N 284 
SER CA  CB   sing N N 285 
SER CA  HA   sing N N 286 
SER C   O    doub N N 287 
SER C   OXT  sing N N 288 
SER CB  OG   sing N N 289 
SER CB  HB2  sing N N 290 
SER CB  HB3  sing N N 291 
SER OG  HG   sing N N 292 
SER OXT HXT  sing N N 293 
THR N   CA   sing N N 294 
THR N   H    sing N N 295 
THR N   H2   sing N N 296 
THR CA  C    sing N N 297 
THR CA  CB   sing N N 298 
THR CA  HA   sing N N 299 
THR C   O    doub N N 300 
THR C   OXT  sing N N 301 
THR CB  OG1  sing N N 302 
THR CB  CG2  sing N N 303 
THR CB  HB   sing N N 304 
THR OG1 HG1  sing N N 305 
THR CG2 HG21 sing N N 306 
THR CG2 HG22 sing N N 307 
THR CG2 HG23 sing N N 308 
THR OXT HXT  sing N N 309 
TRP N   CA   sing N N 310 
TRP N   H    sing N N 311 
TRP N   H2   sing N N 312 
TRP CA  C    sing N N 313 
TRP CA  CB   sing N N 314 
TRP CA  HA   sing N N 315 
TRP C   O    doub N N 316 
TRP C   OXT  sing N N 317 
TRP CB  CG   sing N N 318 
TRP CB  HB2  sing N N 319 
TRP CB  HB3  sing N N 320 
TRP CG  CD1  doub Y N 321 
TRP CG  CD2  sing Y N 322 
TRP CD1 NE1  sing Y N 323 
TRP CD1 HD1  sing N N 324 
TRP CD2 CE2  doub Y N 325 
TRP CD2 CE3  sing Y N 326 
TRP NE1 CE2  sing Y N 327 
TRP NE1 HE1  sing N N 328 
TRP CE2 CZ2  sing Y N 329 
TRP CE3 CZ3  doub Y N 330 
TRP CE3 HE3  sing N N 331 
TRP CZ2 CH2  doub Y N 332 
TRP CZ2 HZ2  sing N N 333 
TRP CZ3 CH2  sing Y N 334 
TRP CZ3 HZ3  sing N N 335 
TRP CH2 HH2  sing N N 336 
TRP OXT HXT  sing N N 337 
TYR N   CA   sing N N 338 
TYR N   H    sing N N 339 
TYR N   H2   sing N N 340 
TYR CA  C    sing N N 341 
TYR CA  CB   sing N N 342 
TYR CA  HA   sing N N 343 
TYR C   O    doub N N 344 
TYR C   OXT  sing N N 345 
TYR CB  CG   sing N N 346 
TYR CB  HB2  sing N N 347 
TYR CB  HB3  sing N N 348 
TYR CG  CD1  doub Y N 349 
TYR CG  CD2  sing Y N 350 
TYR CD1 CE1  sing Y N 351 
TYR CD1 HD1  sing N N 352 
TYR CD2 CE2  doub Y N 353 
TYR CD2 HD2  sing N N 354 
TYR CE1 CZ   doub Y N 355 
TYR CE1 HE1  sing N N 356 
TYR CE2 CZ   sing Y N 357 
TYR CE2 HE2  sing N N 358 
TYR CZ  OH   sing N N 359 
TYR OH  HH   sing N N 360 
TYR OXT HXT  sing N N 361 
VAL N   CA   sing N N 362 
VAL N   H    sing N N 363 
VAL N   H2   sing N N 364 
VAL CA  C    sing N N 365 
VAL CA  CB   sing N N 366 
VAL CA  HA   sing N N 367 
VAL C   O    doub N N 368 
VAL C   OXT  sing N N 369 
VAL CB  CG1  sing N N 370 
VAL CB  CG2  sing N N 371 
VAL CB  HB   sing N N 372 
VAL CG1 HG11 sing N N 373 
VAL CG1 HG12 sing N N 374 
VAL CG1 HG13 sing N N 375 
VAL CG2 HG21 sing N N 376 
VAL CG2 HG22 sing N N 377 
VAL CG2 HG23 sing N N 378 
VAL OXT HXT  sing N N 379 
# 
_pdbx_audit_support.funding_organization   'National Natural Science Foundation of China (NSFC)' 
_pdbx_audit_support.country                China 
_pdbx_audit_support.grant_number           ? 
_pdbx_audit_support.ordinal                1 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      PDB 
_pdbx_initial_refinement_model.accession_code   7AK8 
_pdbx_initial_refinement_model.details          ? 
# 
_space_group.name_H-M_alt     'P 65 2 2' 
_space_group.name_Hall        'P 65 2 (x,y,z+1/12)' 
_space_group.IT_number        179 
_space_group.crystal_system   hexagonal 
_space_group.id               1 
# 
_atom_sites.entry_id                    9ILS 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.012727 
_atom_sites.fract_transf_matrix[1][2]   0.007348 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.014696 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.007579 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C ? ? 3.54356 2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N ? ? 4.01032 2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O ? ? 7.96527 ?       ? ? 9.05267  ?        ? ? 0.0 
;1-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
P ? ? 9.51135 5.44231 ? ? 1.42069  35.72801 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S ? ? 9.55732 6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N N   . GLU A 1 2   ? -9.47462  17.64013 -9.47803  1.000 115.71690 ? 2   GLU A N   1 
ATOM   2    C CA  . GLU A 1 2   ? -10.12266 18.01164 -8.22178  1.000 110.02070 ? 2   GLU A CA  1 
ATOM   3    C C   . GLU A 1 2   ? -9.27023  18.99817 -7.39815  1.000 125.01900 ? 2   GLU A C   1 
ATOM   4    O O   . GLU A 1 2   ? -8.06252  19.15921 -7.63392  1.000 119.03891 ? 2   GLU A O   1 
ATOM   5    C CB  . GLU A 1 2   ? -10.42844 16.75078 -7.40203  1.000 101.26612 ? 2   GLU A CB  1 
ATOM   6    C CG  . GLU A 1 2   ? -9.48962  16.51072 -6.22106  1.000 113.50737 ? 2   GLU A CG  1 
ATOM   7    C CD  . GLU A 1 2   ? -8.08007  16.08365 -6.64262  1.000 122.27656 ? 2   GLU A CD  1 
ATOM   8    O OE1 . GLU A 1 2   ? -7.90854  15.55223 -7.76202  1.000 128.56849 ? 2   GLU A OE1 1 
ATOM   9    O OE2 . GLU A 1 2   ? -7.13899  16.27650 -5.84321  1.000 111.53136 ? 2   GLU A OE2 1 
ATOM   10   N N   . ILE A 1 3   ? -9.91404  19.67017 -6.44485  1.000 112.21595 ? 3   ILE A N   1 
ATOM   11   C CA  . ILE A 1 3   ? -9.24317  20.51147 -5.46218  1.000 93.76633  ? 3   ILE A CA  1 
ATOM   12   C C   . ILE A 1 3   ? -9.48160  19.89889 -4.08539  1.000 93.33139  ? 3   ILE A C   1 
ATOM   13   O O   . ILE A 1 3   ? -10.60359 19.48480 -3.77380  1.000 96.07640  ? 3   ILE A O   1 
ATOM   14   C CB  . ILE A 1 3   ? -9.75113  21.96415 -5.52430  1.000 101.53970 ? 3   ILE A CB  1 
ATOM   15   C CG1 . ILE A 1 3   ? -9.41911  22.58841 -6.88081  1.000 95.38363  ? 3   ILE A CG1 1 
ATOM   16   C CG2 . ILE A 1 3   ? -9.12483  22.79874 -4.40800  1.000 98.42473  ? 3   ILE A CG2 1 
ATOM   17   C CD1 . ILE A 1 3   ? -10.62634 23.04116 -7.66343  1.000 94.80817  ? 3   ILE A CD1 1 
ATOM   18   N N   . ASN A 1 4   ? -8.42497  19.81761 -3.27878  1.000 92.66768  ? 4   ASN A N   1 
ATOM   19   C CA  . ASN A 1 4   ? -8.48232  19.28923 -1.91931  1.000 92.35158  ? 4   ASN A CA  1 
ATOM   20   C C   . ASN A 1 4   ? -8.12655  20.39201 -0.93306  1.000 93.40669  ? 4   ASN A C   1 
ATOM   21   O O   . ASN A 1 4   ? -7.08363  21.03518 -1.08182  1.000 98.37639  ? 4   ASN A O   1 
ATOM   22   C CB  . ASN A 1 4   ? -7.50582  18.12874 -1.73399  1.000 116.21667 ? 4   ASN A CB  1 
ATOM   23   C CG  . ASN A 1 4   ? -8.09915  16.79652 -2.11523  1.000 117.24189 ? 4   ASN A CG  1 
ATOM   24   O OD1 . ASN A 1 4   ? -7.46121  15.75777 -1.93468  1.000 107.34673 ? 4   ASN A OD1 1 
ATOM   25   N ND2 . ASN A 1 4   ? -9.32278  16.81369 -2.65457  1.000 103.49802 ? 4   ASN A ND2 1 
ATOM   26   N N   . VAL A 1 5   ? -8.96096  20.58547 0.09446   1.000 93.36548  ? 5   VAL A N   1 
ATOM   27   C CA  . VAL A 1 5   ? -8.81925  21.73690 0.98153   1.000 99.72822  ? 5   VAL A CA  1 
ATOM   28   C C   . VAL A 1 5   ? -8.69646  21.28858 2.43698   1.000 90.73978  ? 5   VAL A C   1 
ATOM   29   O O   . VAL A 1 5   ? -9.11515  20.19670 2.82788   1.000 85.37770  ? 5   VAL A O   1 
ATOM   30   C CB  . VAL A 1 5   ? -9.97837  22.74621 0.82591   1.000 89.28093  ? 5   VAL A CB  1 
ATOM   31   C CG1 . VAL A 1 5   ? -9.81428  23.54887 -0.46403  1.000 89.34994  ? 5   VAL A CG1 1 
ATOM   32   C CG2 . VAL A 1 5   ? -11.32241 22.05097 0.88619   1.000 90.52989  ? 5   VAL A CG2 1 
ATOM   33   N N   . THR A 1 6   ? -8.10455  22.16622 3.24099   1.000 104.40369 ? 6   THR A N   1 
ATOM   34   C CA  . THR A 1 6   ? -7.88707  21.94121 4.66195   1.000 99.98860  ? 6   THR A CA  1 
ATOM   35   C C   . THR A 1 6   ? -9.02942  22.53096 5.48440   1.000 105.66473 ? 6   THR A C   1 
ATOM   36   O O   . THR A 1 6   ? -9.84574  23.31890 4.99711   1.000 106.10031 ? 6   THR A O   1 
ATOM   37   C CB  . THR A 1 6   ? -6.56063  22.55564 5.12061   1.000 102.65031 ? 6   THR A CB  1 
ATOM   38   O OG1 . THR A 1 6   ? -6.76224  23.93462 5.46140   1.000 113.31031 ? 6   THR A OG1 1 
ATOM   39   C CG2 . THR A 1 6   ? -5.53203  22.46859 4.01220   1.000 112.24031 ? 6   THR A CG2 1 
ATOM   40   N N   . ALA A 1 7   ? -9.04987  22.15881 6.76223   1.000 104.99192 ? 7   ALA A N   1 
ATOM   41   C CA  . ALA A 1 7   ? -10.14969 22.52347 7.63955   1.000 84.70695  ? 7   ALA A CA  1 
ATOM   42   C C   . ALA A 1 7   ? -10.13938 24.02325 7.94071   1.000 79.11945  ? 7   ALA A C   1 
ATOM   43   O O   . ALA A 1 7   ? -9.07340  24.61420 8.14925   1.000 72.90559  ? 7   ALA A O   1 
ATOM   44   C CB  . ALA A 1 7   ? -10.07031 21.72778 8.94198   1.000 83.39890  ? 7   ALA A CB  1 
ATOM   45   N N   . PRO A 1 8   ? -11.32602 24.64418 8.00147   1.000 90.61811  ? 8   PRO A N   1 
ATOM   46   C CA  . PRO A 1 8   ? -11.41522 26.09554 8.24906   1.000 73.81088  ? 8   PRO A CA  1 
ATOM   47   C C   . PRO A 1 8   ? -10.73645 26.50164 9.55057   1.000 83.13589  ? 8   PRO A C   1 
ATOM   48   O O   . PRO A 1 8   ? -10.95742 25.90031 10.60629  1.000 71.97674  ? 8   PRO A O   1 
ATOM   49   C CB  . PRO A 1 8   ? -12.93024 26.34962 8.30426   1.000 69.28608  ? 8   PRO A CB  1 
ATOM   50   C CG  . PRO A 1 8   ? -13.55493 25.20504 7.58459   1.000 72.47196  ? 8   PRO A CG  1 
ATOM   51   C CD  . PRO A 1 8   ? -12.66256 24.02449 7.88249   1.000 84.54393  ? 8   PRO A CD  1 
ATOM   52   N N   . ALA A 1 9   ? -9.91719  27.55162 9.46832   1.000 79.91983  ? 9   ALA A N   1 
ATOM   53   C CA  . ALA A 1 9   ? -9.06321  27.95561 10.57009  1.000 62.77293  ? 9   ALA A CA  1 
ATOM   54   C C   . ALA A 1 9   ? -8.89125  29.46390 10.54348  1.000 66.40799  ? 9   ALA A C   1 
ATOM   55   O O   . ALA A 1 9   ? -8.91881  30.09344 9.48445   1.000 61.41710  ? 9   ALA A O   1 
ATOM   56   C CB  . ALA A 1 9   ? -7.70231  27.25603 10.50853  1.000 60.97359  ? 9   ALA A CB  1 
ATOM   57   N N   . LEU A 1 10  ? -8.72910  30.02768 11.74206  1.000 75.76692  ? 10  LEU A N   1 
ATOM   58   C CA  . LEU A 1 10  ? -8.64160  31.46846 11.91839  1.000 68.09069  ? 10  LEU A CA  1 
ATOM   59   C C   . LEU A 1 10  ? -7.53207  32.04482 11.05014  1.000 89.58236  ? 10  LEU A C   1 
ATOM   60   O O   . LEU A 1 10  ? -6.48808  31.42325 10.83994  1.000 86.67006  ? 10  LEU A O   1 
ATOM   61   C CB  . LEU A 1 10  ? -8.39371  31.81402 13.39567  1.000 63.03101  ? 10  LEU A CB  1 
ATOM   62   C CG  . LEU A 1 10  ? -9.53810  32.52035 14.15342  1.000 83.87510  ? 10  LEU A CG  1 
ATOM   63   C CD1 . LEU A 1 10  ? -9.23456  32.83027 15.61814  1.000 62.47773  ? 10  LEU A CD1 1 
ATOM   64   C CD2 . LEU A 1 10  ? -10.01353 33.77782 13.44492  1.000 92.71292  ? 10  LEU A CD2 1 
ATOM   65   N N   . LEU A 1 11  ? -7.77334  33.24307 10.53150  1.000 87.50096  ? 11  LEU A N   1 
ATOM   66   C CA  . LEU A 1 11  ? -6.79382  33.87943 9.67221   1.000 76.24811  ? 11  LEU A CA  1 
ATOM   67   C C   . LEU A 1 11  ? -5.55074  34.22729 10.47950  1.000 94.16246  ? 11  LEU A C   1 
ATOM   68   O O   . LEU A 1 11  ? -5.65395  34.76196 11.58977  1.000 96.48541  ? 11  LEU A O   1 
ATOM   69   C CB  . LEU A 1 11  ? -7.40449  35.12031 9.02924   1.000 69.61340  ? 11  LEU A CB  1 
ATOM   70   C CG  . LEU A 1 11  ? -6.46815  35.93291 8.15277   1.000 70.99561  ? 11  LEU A CG  1 
ATOM   71   C CD1 . LEU A 1 11  ? -5.88334  35.05371 7.03894   1.000 71.45215  ? 11  LEU A CD1 1 
ATOM   72   C CD2 . LEU A 1 11  ? -7.23382  37.10109 7.58581   1.000 71.62668  ? 11  LEU A CD2 1 
ATOM   73   N N   . THR A 1 12  ? -4.37548  33.89281 9.93377   1.000 96.93547  ? 12  THR A N   1 
ATOM   74   C CA  . THR A 1 12  ? -3.09935  34.27603 10.51852  1.000 97.65393  ? 12  THR A CA  1 
ATOM   75   C C   . THR A 1 12  ? -2.51174  35.42313 9.69784   1.000 96.65728  ? 12  THR A C   1 
ATOM   76   O O   . THR A 1 12  ? -3.20635  36.06780 8.90201   1.000 97.08440  ? 12  THR A O   1 
ATOM   77   C CB  . THR A 1 12  ? -2.12395  33.08939 10.55553  1.000 95.64739  ? 12  THR A CB  1 
ATOM   78   O OG1 . THR A 1 12  ? -2.83890  31.87483 10.79213  1.000 97.50676  ? 12  THR A OG1 1 
ATOM   79   C CG2 . THR A 1 12  ? -1.10776  33.27564 11.69616  1.000 95.32585  ? 12  THR A CG2 1 
ATOM   80   N N   . ASP A 1 13  ? -1.21973  35.67029 9.86284   1.000 115.47539 ? 13  ASP A N   1 
ATOM   81   C CA  . ASP A 1 13  ? -0.53881  36.65322 9.04582   1.000 113.07646 ? 13  ASP A CA  1 
ATOM   82   C C   . ASP A 1 13  ? 0.36606   36.01440 7.99694   1.000 101.21081 ? 13  ASP A C   1 
ATOM   83   O O   . ASP A 1 13  ? 0.68676   36.67140 7.00300   1.000 112.18795 ? 13  ASP A O   1 
ATOM   84   C CB  . ASP A 1 13  ? 0.24510   37.62105 9.95086   1.000 102.30355 ? 13  ASP A CB  1 
ATOM   85   C CG  . ASP A 1 13  ? -0.63353  38.21480 11.08151  1.000 112.52316 ? 13  ASP A CG  1 
ATOM   86   O OD1 . ASP A 1 13  ? -1.21841  37.44530 11.88269  1.000 108.87159 ? 13  ASP A OD1 1 
ATOM   87   O OD2 . ASP A 1 13  ? -0.76531  39.45689 11.15001  1.000 104.06139 ? 13  ASP A OD2 1 
ATOM   88   N N   . GLU A 1 14  ? 0.72992   34.73564 8.16031   1.000 92.51089  ? 14  GLU A N   1 
ATOM   89   C CA  . GLU A 1 14  ? 1.45804   33.98823 7.13887   1.000 107.28672 ? 14  GLU A CA  1 
ATOM   90   C C   . GLU A 1 14  ? 0.53722   33.32695 6.11524   1.000 104.93503 ? 14  GLU A C   1 
ATOM   91   O O   . GLU A 1 14  ? 1.02541   32.61114 5.23260   1.000 107.80473 ? 14  GLU A O   1 
ATOM   92   C CB  . GLU A 1 14  ? 2.34627   32.92123 7.79162   1.000 110.34456 ? 14  GLU A CB  1 
ATOM   93   C CG  . GLU A 1 14  ? 1.58430   31.90995 8.64138   1.000 114.98820 ? 14  GLU A CG  1 
ATOM   94   C CD  . GLU A 1 14  ? 1.62201   32.22029 10.12959  1.000 118.53005 ? 14  GLU A CD  1 
ATOM   95   O OE1 . GLU A 1 14  ? 1.67681   33.41840 10.48234  1.000 117.10095 ? 14  GLU A OE1 1 
ATOM   96   O OE2 . GLU A 1 14  ? 1.56064   31.26963 10.94492  1.000 128.39481 ? 14  GLU A OE2 1 
ATOM   97   N N   . HIS A 1 15  ? -0.77102  33.54537 6.19868   1.000 101.03058 ? 15  HIS A N   1 
ATOM   98   C CA  . HIS A 1 15  ? -1.67972  32.95461 5.22950   1.000 86.69492  ? 15  HIS A CA  1 
ATOM   99   C C   . HIS A 1 15  ? -1.56748  33.67448 3.89638   1.000 83.04006  ? 15  HIS A C   1 
ATOM   100  O O   . HIS A 1 15  ? -1.35228  34.88821 3.83869   1.000 90.62593  ? 15  HIS A O   1 
ATOM   101  C CB  . HIS A 1 15  ? -3.11485  33.00206 5.75000   1.000 93.80178  ? 15  HIS A CB  1 
ATOM   102  C CG  . HIS A 1 15  ? -3.52974  31.74697 6.44252   1.000 80.46570  ? 15  HIS A CG  1 
ATOM   103  N ND1 . HIS A 1 15  ? -3.90920  31.71886 7.76519   1.000 87.73747  ? 15  HIS A ND1 1 
ATOM   104  C CD2 . HIS A 1 15  ? -3.58861  30.46690 6.00543   1.000 78.18447  ? 15  HIS A CD2 1 
ATOM   105  C CE1 . HIS A 1 15  ? -4.19998  30.47663 8.11081   1.000 92.49028  ? 15  HIS A CE1 1 
ATOM   106  N NE2 . HIS A 1 15  ? -4.01284  29.69659 7.06069   1.000 79.59477  ? 15  HIS A NE2 1 
ATOM   107  N N   . ILE A 1 16  ? -1.70151  32.90924 2.81619   1.000 88.68648  ? 16  ILE A N   1 
ATOM   108  C CA  . ILE A 1 16  ? -1.54198  33.43770 1.46510   1.000 85.22549  ? 16  ILE A CA  1 
ATOM   109  C C   . ILE A 1 16  ? -2.90329  33.98502 1.02189   1.000 80.47276  ? 16  ILE A C   1 
ATOM   110  O O   . ILE A 1 16  ? -3.82855  33.21738 0.74031   1.000 76.03203  ? 16  ILE A O   1 
ATOM   111  C CB  . ILE A 1 16  ? -1.00935  32.35941 0.50960   1.000 74.48966  ? 16  ILE A CB  1 
ATOM   112  C CG1 . ILE A 1 16  ? 0.36592   31.86715 0.95637   1.000 71.41077  ? 16  ILE A CG1 1 
ATOM   113  C CG2 . ILE A 1 16  ? -0.82531  32.89754 -0.88540  1.000 87.28150  ? 16  ILE A CG2 1 
ATOM   114  C CD1 . ILE A 1 16  ? 0.95517   30.83562 0.01685   1.000 73.30366  ? 16  ILE A CD1 1 
ATOM   115  N N   . LEU A 1 17  ? -3.02783  35.32049 0.97139   1.000 82.09836  ? 17  LEU A N   1 
ATOM   116  C CA  . LEU A 1 17  ? -4.28781  36.00863 0.69808   1.000 88.17676  ? 17  LEU A CA  1 
ATOM   117  C C   . LEU A 1 17  ? -4.35683  36.64895 -0.68673  1.000 92.28059  ? 17  LEU A C   1 
ATOM   118  O O   . LEU A 1 17  ? -5.41954  37.16628 -1.07881  1.000 94.96303  ? 17  LEU A O   1 
ATOM   119  C CB  . LEU A 1 17  ? -4.53597  37.08695 1.76368   1.000 82.83191  ? 17  LEU A CB  1 
ATOM   120  C CG  . LEU A 1 17  ? -3.87497  38.46508 1.73112   1.000 86.10526  ? 17  LEU A CG  1 
ATOM   121  C CD1 . LEU A 1 17  ? -4.63008  39.46138 0.82030   1.000 84.94097  ? 17  LEU A CD1 1 
ATOM   122  C CD2 . LEU A 1 17  ? -3.72638  39.00777 3.15753   1.000 88.78746  ? 17  LEU A CD2 1 
ATOM   123  N N   . GLN A 1 18  ? -3.26631  36.65763 -1.42491  1.000 88.59036  ? 18  GLN A N   1 
ATOM   124  C CA  . GLN A 1 18  ? -3.25541  37.37791 -2.68868  1.000 81.84460  ? 18  GLN A CA  1 
ATOM   125  C C   . GLN A 1 18  ? -3.96221  36.58552 -3.79176  1.000 92.37846  ? 18  GLN A C   1 
ATOM   126  O O   . GLN A 1 18  ? -4.89510  37.12473 -4.40628  1.000 89.56024  ? 18  GLN A O   1 
ATOM   127  C CB  . GLN A 1 18  ? -1.81846  37.73693 -3.08450  1.000 84.98544  ? 18  GLN A CB  1 
ATOM   128  N N   . PRO A 1 19  ? -3.59992  35.31716 -4.05870  1.000 97.75070  ? 19  PRO A N   1 
ATOM   129  C CA  . PRO A 1 19  ? -4.24056  34.59038 -5.17556  1.000 102.06930 ? 19  PRO A CA  1 
ATOM   130  C C   . PRO A 1 19  ? -5.75638  34.39060 -5.03317  1.000 101.26362 ? 19  PRO A C   1 
ATOM   131  O O   . PRO A 1 19  ? -6.36856  33.87458 -5.97709  1.000 99.86859  ? 19  PRO A O   1 
ATOM   132  C CB  . PRO A 1 19  ? -3.50884  33.23753 -5.18092  1.000 87.08136  ? 19  PRO A CB  1 
ATOM   133  C CG  . PRO A 1 19  ? -2.20903  33.48997 -4.50192  1.000 89.07978  ? 19  PRO A CG  1 
ATOM   134  C CD  . PRO A 1 19  ? -2.55367  34.48649 -3.42649  1.000 82.74086  ? 19  PRO A CD  1 
ATOM   135  N N   . PHE A 1 20  ? -6.37513  34.79359 -3.91794  1.000 100.78156 ? 20  PHE A N   1 
ATOM   136  C CA  . PHE A 1 20  ? -7.80338  34.57114 -3.72028  1.000 87.55336  ? 20  PHE A CA  1 
ATOM   137  C C   . PHE A 1 20  ? -8.63722  35.48693 -4.61894  1.000 102.90499 ? 20  PHE A C   1 
ATOM   138  O O   . PHE A 1 20  ? -8.49446  36.71320 -4.57022  1.000 94.98982  ? 20  PHE A O   1 
ATOM   139  C CB  . PHE A 1 20  ? -8.16165  34.77584 -2.24721  1.000 85.35733  ? 20  PHE A CB  1 
ATOM   140  C CG  . PHE A 1 20  ? -9.57612  34.41871 -1.92194  1.000 78.06062  ? 20  PHE A CG  1 
ATOM   141  C CD1 . PHE A 1 20  ? -10.55571 35.38962 -1.86320  1.000 85.74561  ? 20  PHE A CD1 1 
ATOM   142  C CD2 . PHE A 1 20  ? -9.93722  33.10667 -1.71013  1.000 77.21080  ? 20  PHE A CD2 1 
ATOM   143  C CE1 . PHE A 1 20  ? -11.86910 35.05055 -1.58291  1.000 94.80302  ? 20  PHE A CE1 1 
ATOM   144  C CE2 . PHE A 1 20  ? -11.24403 32.76986 -1.42920  1.000 79.16460  ? 20  PHE A CE2 1 
ATOM   145  C CZ  . PHE A 1 20  ? -12.21009 33.73575 -1.36441  1.000 75.56876  ? 20  PHE A CZ  1 
ATOM   146  N N   . ASP A 1 21  ? -9.50747  34.87891 -5.44165  1.000 86.40152  ? 21  ASP A N   1 
ATOM   147  C CA  . ASP A 1 21  ? -10.37270 35.58429 -6.39376  1.000 89.05403  ? 21  ASP A CA  1 
ATOM   148  C C   . ASP A 1 21  ? -11.75307 34.93188 -6.34980  1.000 100.58546 ? 21  ASP A C   1 
ATOM   149  O O   . ASP A 1 21  ? -11.91836 33.81641 -6.85038  1.000 101.51496 ? 21  ASP A O   1 
ATOM   150  C CB  . ASP A 1 21  ? -9.77740  35.53575 -7.81125  1.000 101.21768 ? 21  ASP A CB  1 
ATOM   151  C CG  . ASP A 1 21  ? -10.00682 36.82393 -8.61907  1.000 111.67191 ? 21  ASP A CG  1 
ATOM   152  O OD1 . ASP A 1 21  ? -9.21868  37.07460 -9.56792  1.000 106.64443 ? 21  ASP A OD1 1 
ATOM   153  O OD2 . ASP A 1 21  ? -10.95758 37.57942 -8.31950  1.000 127.74010 ? 21  ASP A OD2 1 
ATOM   154  N N   . CYS A 1 22  ? -12.74640 35.62127 -5.77418  1.000 107.82872 ? 22  CYS A N   1 
ATOM   155  C CA  . CYS A 1 22  ? -14.06760 35.02790 -5.57624  1.000 103.91900 ? 22  CYS A CA  1 
ATOM   156  C C   . CYS A 1 22  ? -15.12007 35.50866 -6.57859  1.000 103.97843 ? 22  CYS A C   1 
ATOM   157  O O   . CYS A 1 22  ? -16.07278 34.76915 -6.85852  1.000 102.93031 ? 22  CYS A O   1 
ATOM   158  C CB  . CYS A 1 22  ? -14.55106 35.28525 -4.13710  1.000 95.08334  ? 22  CYS A CB  1 
ATOM   159  S SG  . CYS A 1 22  ? -15.50017 36.81387 -3.80931  1.000 148.47158 ? 22  CYS A SG  1 
ATOM   160  N N   . GLY A 1 23  ? -14.96294 36.70861 -7.15364  1.000 107.95186 ? 23  GLY A N   1 
ATOM   161  C CA  . GLY A 1 23  ? -15.89907 37.26604 -8.11863  1.000 97.94940  ? 23  GLY A CA  1 
ATOM   162  C C   . GLY A 1 23  ? -16.47106 38.61487 -7.67808  1.000 109.06763 ? 23  GLY A C   1 
ATOM   163  O O   . GLY A 1 23  ? -16.83594 39.43383 -8.52696  1.000 96.19988  ? 23  GLY A O   1 
ATOM   164  N N   . ASN A 1 24  ? -16.53781 38.82700 -6.36822  1.000 115.52252 ? 24  ASN A N   1 
ATOM   165  C CA  . ASN A 1 24  ? -16.91780 40.10724 -5.77401  1.000 111.69116 ? 24  ASN A CA  1 
ATOM   166  C C   . ASN A 1 24  ? -15.65717 40.71956 -5.17025  1.000 98.20653  ? 24  ASN A C   1 
ATOM   167  O O   . ASN A 1 24  ? -15.12037 40.21686 -4.17793  1.000 91.28031  ? 24  ASN A O   1 
ATOM   168  C CB  . ASN A 1 24  ? -18.01410 39.89887 -4.73968  1.000 98.85980  ? 24  ASN A CB  1 
ATOM   169  C CG  . ASN A 1 24  ? -18.55139 41.19232 -4.19954  1.000 103.15554 ? 24  ASN A CG  1 
ATOM   170  O OD1 . ASN A 1 24  ? -18.43377 42.24715 -4.83539  1.000 113.87201 ? 24  ASN A OD1 1 
ATOM   171  N ND2 . ASN A 1 24  ? -19.15142 41.12684 -3.02557  1.000 99.59100  ? 24  ASN A ND2 1 
ATOM   172  N N   . GLU A 1 25  ? -15.17690 41.79831 -5.79322  1.000 94.67273  ? 25  GLU A N   1 
ATOM   173  C CA  . GLU A 1 25  ? -13.98889 42.48405 -5.29390  1.000 90.31563  ? 25  GLU A CA  1 
ATOM   174  C C   . GLU A 1 25  ? -14.18562 42.97343 -3.86590  1.000 91.94110  ? 25  GLU A C   1 
ATOM   175  O O   . GLU A 1 25  ? -13.21087 43.11986 -3.11974  1.000 96.85530  ? 25  GLU A O   1 
ATOM   176  C CB  . GLU A 1 25  ? -13.62938 43.66108 -6.21955  1.000 87.14124  ? 25  GLU A CB  1 
ATOM   177  C CG  . GLU A 1 25  ? -12.11887 43.91962 -6.46273  1.000 88.08224  ? 25  GLU A CG  1 
ATOM   178  C CD  . GLU A 1 25  ? -11.47941 43.08069 -7.57376  1.000 98.97267  ? 25  GLU A CD  1 
ATOM   179  O OE1 . GLU A 1 25  ? -11.71051 43.38820 -8.76681  1.000 102.39031 ? 25  GLU A OE1 1 
ATOM   180  O OE2 . GLU A 1 25  ? -10.71171 42.14460 -7.26326  1.000 114.79639 ? 25  GLU A OE2 1 
ATOM   181  N N   . VAL A 1 26  ? -15.43781 43.22335 -3.46063  1.000 97.80453  ? 26  VAL A N   1 
ATOM   182  C CA  . VAL A 1 26  ? -15.69026 43.68881 -2.09499  1.000 104.27600 ? 26  VAL A CA  1 
ATOM   183  C C   . VAL A 1 26  ? -15.23884 42.62659 -1.09508  1.000 103.44285 ? 26  VAL A C   1 
ATOM   184  O O   . VAL A 1 26  ? -14.50895 42.91470 -0.13484  1.000 103.70391 ? 26  VAL A O   1 
ATOM   185  C CB  . VAL A 1 26  ? -17.17442 44.05867 -1.90296  1.000 86.99670  ? 26  VAL A CB  1 
ATOM   186  C CG1 . VAL A 1 26  ? -17.42616 44.67213 -0.51460  1.000 82.24751  ? 26  VAL A CG1 1 
ATOM   187  C CG2 . VAL A 1 26  ? -17.64775 45.00402 -3.00948  1.000 77.78999  ? 26  VAL A CG2 1 
ATOM   188  N N   . LEU A 1 27  ? -15.60301 41.36339 -1.36419  1.000 107.94469 ? 27  LEU A N   1 
ATOM   189  C CA  . LEU A 1 27  ? -15.32376 40.26521 -0.43694  1.000 111.25858 ? 27  LEU A CA  1 
ATOM   190  C C   . LEU A 1 27  ? -13.87719 39.77612 -0.51581  1.000 106.73917 ? 27  LEU A C   1 
ATOM   191  O O   . LEU A 1 27  ? -13.36716 39.21956 0.46444   1.000 100.64413 ? 27  LEU A O   1 
ATOM   192  C CB  . LEU A 1 27  ? -16.29120 39.10420 -0.69474  1.000 101.57224 ? 27  LEU A CB  1 
ATOM   193  N N   . SER A 1 28  ? -13.20711 39.95650 -1.66033  1.000 104.33109 ? 28  SER A N   1 
ATOM   194  C CA  . SER A 1 28  ? -11.76536 39.72042 -1.71854  1.000 95.19056  ? 28  SER A CA  1 
ATOM   195  C C   . SER A 1 28  ? -10.98022 40.86614 -1.07871  1.000 88.72580  ? 28  SER A C   1 
ATOM   196  O O   . SER A 1 28  ? -9.89275  40.64517 -0.52842  1.000 90.01466  ? 28  SER A O   1 
ATOM   197  C CB  . SER A 1 28  ? -11.33236 39.49205 -3.17397  1.000 100.83058 ? 28  SER A CB  1 
ATOM   198  O OG  . SER A 1 28  ? -11.13804 40.70700 -3.87938  1.000 90.25750  ? 28  SER A OG  1 
ATOM   199  N N   . ASN A 1 29  ? -11.51762 42.09027 -1.12343  1.000 99.84998  ? 29  ASN A N   1 
ATOM   200  C CA  . ASN A 1 29  ? -10.84090 43.21606 -0.48164  1.000 101.75763 ? 29  ASN A CA  1 
ATOM   201  C C   . ASN A 1 29  ? -10.92590 43.12243 1.03908   1.000 104.76471 ? 29  ASN A C   1 
ATOM   202  O O   . ASN A 1 29  ? -9.93304  43.38618 1.73220   1.000 107.43288 ? 29  ASN A O   1 
ATOM   203  C CB  . ASN A 1 29  ? -11.41165 44.55429 -0.96577  1.000 82.46745  ? 29  ASN A CB  1 
ATOM   204  C CG  . ASN A 1 29  ? -10.85428 44.98690 -2.31777  1.000 78.75397  ? 29  ASN A CG  1 
ATOM   205  O OD1 . ASN A 1 29  ? -9.91663  44.39138 -2.84385  1.000 77.89972  ? 29  ASN A OD1 1 
ATOM   206  N ND2 . ASN A 1 29  ? -11.41247 46.06055 -2.86279  1.000 74.13977  ? 29  ASN A ND2 1 
ATOM   207  N N   . TRP A 1 30  ? -12.09768 42.75015 1.57692   1.000 94.04609  ? 30  TRP A N   1 
ATOM   208  C CA  . TRP A 1 30  ? -12.22682 42.58528 3.02345   1.000 86.12549  ? 30  TRP A CA  1 
ATOM   209  C C   . TRP A 1 30  ? -11.16125 41.63229 3.55645   1.000 79.91245  ? 30  TRP A C   1 
ATOM   210  O O   . TRP A 1 30  ? -10.49625 41.93246 4.55241   1.000 81.10578  ? 30  TRP A O   1 
ATOM   211  C CB  . TRP A 1 30  ? -13.63672 42.09652 3.38021   1.000 79.62115  ? 30  TRP A CB  1 
ATOM   212  C CG  . TRP A 1 30  ? -13.96830 42.23958 4.84560   1.000 79.64973  ? 30  TRP A CG  1 
ATOM   213  C CD1 . TRP A 1 30  ? -14.50390 43.33899 5.45597   1.000 80.60933  ? 30  TRP A CD1 1 
ATOM   214  C CD2 . TRP A 1 30  ? -13.81348 41.24677 5.87299   1.000 83.01675  ? 30  TRP A CD2 1 
ATOM   215  N NE1 . TRP A 1 30  ? -14.67063 43.10203 6.80324   1.000 80.67597  ? 30  TRP A NE1 1 
ATOM   216  C CE2 . TRP A 1 30  ? -14.26031 41.82393 7.08480   1.000 83.18887  ? 30  TRP A CE2 1 
ATOM   217  C CE3 . TRP A 1 30  ? -13.32583 39.93471 5.89021   1.000 75.17566  ? 30  TRP A CE3 1 
ATOM   218  C CZ2 . TRP A 1 30  ? -14.23669 41.12718 8.30443   1.000 77.00684  ? 30  TRP A CZ2 1 
ATOM   219  C CZ3 . TRP A 1 30  ? -13.30442 39.24426 7.09918   1.000 71.93216  ? 30  TRP A CZ3 1 
ATOM   220  C CH2 . TRP A 1 30  ? -13.75615 39.84389 8.28892   1.000 71.76935  ? 30  TRP A CH2 1 
ATOM   221  N N   . LEU A 1 31  ? -10.94842 40.50486 2.86573   1.000 80.20454  ? 31  LEU A N   1 
ATOM   222  C CA  . LEU A 1 31  ? -9.93375  39.53474 3.27357   1.000 77.61186  ? 31  LEU A CA  1 
ATOM   223  C C   . LEU A 1 31  ? -8.53363  40.13732 3.23060   1.000 95.90113  ? 31  LEU A C   1 
ATOM   224  O O   . LEU A 1 31  ? -7.70098  39.85576 4.10121   1.000 86.32267  ? 31  LEU A O   1 
ATOM   225  C CB  . LEU A 1 31  ? -10.00662 38.29340 2.38108   1.000 72.46542  ? 31  LEU A CB  1 
ATOM   226  C CG  . LEU A 1 31  ? -9.11034  37.09753 2.75126   1.000 80.59934  ? 31  LEU A CG  1 
ATOM   227  C CD1 . LEU A 1 31  ? -9.62002  36.44757 4.03122   1.000 69.32353  ? 31  LEU A CD1 1 
ATOM   228  C CD2 . LEU A 1 31  ? -8.95430  36.05220 1.62293   1.000 66.13795  ? 31  LEU A CD2 1 
ATOM   229  N N   . ARG A 1 32  ? -8.24962  40.95722 2.21586   1.000 101.08648 ? 32  ARG A N   1 
ATOM   230  C CA  . ARG A 1 32  ? -6.94491  41.59981 2.12449   1.000 86.63281  ? 32  ARG A CA  1 
ATOM   231  C C   . ARG A 1 32  ? -6.77751  42.68854 3.18294   1.000 81.00948  ? 32  ARG A C   1 
ATOM   232  O O   . ARG A 1 32  ? -5.70732  42.79720 3.79335   1.000 80.51902  ? 32  ARG A O   1 
ATOM   233  C CB  . ARG A 1 32  ? -6.74076  42.16782 0.71966   1.000 87.11594  ? 32  ARG A CB  1 
ATOM   234  N N   . GLY A 1 33  ? -7.83206  43.46609 3.44517   1.000 79.16350  ? 33  GLY A N   1 
ATOM   235  C CA  . GLY A 1 33  ? -7.75184  44.64963 4.28440   1.000 84.42404  ? 33  GLY A CA  1 
ATOM   236  C C   . GLY A 1 33  ? -8.38929  44.62692 5.66570   1.000 102.23728 ? 33  GLY A C   1 
ATOM   237  O O   . GLY A 1 33  ? -7.68767  44.83259 6.66298   1.000 100.32031 ? 33  GLY A O   1 
ATOM   238  N N   . ARG A 1 34  ? -9.71425  44.41346 5.74583   1.000 122.21212 ? 34  ARG A N   1 
ATOM   239  C CA  . ARG A 1 34  ? -10.48981 44.59526 6.97839   1.000 109.65537 ? 34  ARG A CA  1 
ATOM   240  C C   . ARG A 1 34  ? -10.69639 43.29865 7.75937   1.000 102.04547 ? 34  ARG A C   1 
ATOM   241  O O   . ARG A 1 34  ? -11.50280 43.26661 8.69649   1.000 91.76934  ? 34  ARG A O   1 
ATOM   242  C CB  . ARG A 1 34  ? -11.83508 45.24875 6.66187   1.000 88.83182  ? 34  ARG A CB  1 
ATOM   243  N N   . ALA A 1 35  ? -9.96669  42.24004 7.39710   1.000 108.54651 ? 35  ALA A N   1 
ATOM   244  C CA  . ALA A 1 35  ? -9.96898  40.97440 8.13417   1.000 87.17391  ? 35  ALA A CA  1 
ATOM   245  C C   . ALA A 1 35  ? -9.01646  41.00077 9.32282   1.000 109.55848 ? 35  ALA A C   1 
ATOM   246  O O   . ALA A 1 35  ? -9.44977  40.89603 10.47432  1.000 114.35004 ? 35  ALA A O   1 
ATOM   247  C CB  . ALA A 1 35  ? -9.60094  39.82026 7.19766   1.000 81.10241  ? 35  ALA A CB  1 
ATOM   248  N N   . MET A 1 36  ? -7.70743  41.10283 9.05374   1.000 118.42982 ? 36  MET A N   1 
ATOM   249  C CA  . MET A 1 36  ? -6.72516  41.10538 10.13894  1.000 114.95053 ? 36  MET A CA  1 
ATOM   250  C C   . MET A 1 36  ? -7.03828  42.20455 11.14971  1.000 125.45184 ? 36  MET A C   1 
ATOM   251  O O   . MET A 1 36  ? -7.03776  41.96773 12.36535  1.000 136.67151 ? 36  MET A O   1 
ATOM   252  C CB  . MET A 1 36  ? -5.29681  41.26005 9.59110   1.000 86.39936  ? 36  MET A CB  1 
ATOM   253  N N   . LYS A 1 37  ? -7.37605  43.39864 10.65226  1.000 127.28490 ? 37  LYS A N   1 
ATOM   254  C CA  . LYS A 1 37  ? -7.68158  44.57946 11.46102  1.000 122.66242 ? 37  LYS A CA  1 
ATOM   255  C C   . LYS A 1 37  ? -8.82441  44.40325 12.46086  1.000 121.85189 ? 37  LYS A C   1 
ATOM   256  O O   . LYS A 1 37  ? -8.68190  44.81617 13.61914  1.000 128.71003 ? 37  LYS A O   1 
ATOM   257  C CB  . LYS A 1 37  ? -8.01202  45.75943 10.54729  1.000 113.16538 ? 37  LYS A CB  1 
ATOM   258  C CG  . LYS A 1 37  ? -6.80802  46.41316 9.89743   1.000 105.18913 ? 37  LYS A CG  1 
ATOM   259  C CD  . LYS A 1 37  ? -5.51726  46.19432 10.66823  1.000 99.85790  ? 37  LYS A CD  1 
ATOM   260  C CE  . LYS A 1 37  ? -4.37115  46.47217 9.73780   1.000 95.46644  ? 37  LYS A CE  1 
ATOM   261  N NZ  . LYS A 1 37  ? -4.57685  45.59723 8.55302   1.000 88.75530  ? 37  LYS A NZ  1 
ATOM   262  N N   . ASN A 1 38  ? -9.96851  43.83702 12.02444  1.000 116.15695 ? 38  ASN A N   1 
ATOM   263  C CA  . ASN A 1 38  ? -11.10587 43.63025 12.93183  1.000 109.78995 ? 38  ASN A CA  1 
ATOM   264  C C   . ASN A 1 38  ? -10.76392 42.61363 14.01154  1.000 104.40998 ? 38  ASN A C   1 
ATOM   265  O O   . ASN A 1 38  ? -11.38352 42.61598 15.07981  1.000 90.16360  ? 38  ASN A O   1 
ATOM   266  C CB  . ASN A 1 38  ? -12.37645 43.17550 12.17448  1.000 108.09509 ? 38  ASN A CB  1 
ATOM   267  C CG  . ASN A 1 38  ? -13.48767 44.24313 12.15844  1.000 107.22475 ? 38  ASN A CG  1 
ATOM   268  O OD1 . ASN A 1 38  ? -13.20513 45.44146 12.08797  1.000 121.50839 ? 38  ASN A OD1 1 
ATOM   269  N ND2 . ASN A 1 38  ? -14.75095 43.80254 12.23484  1.000 83.04031  ? 38  ASN A ND2 1 
ATOM   270  N N   . GLN A 1 39  ? -9.78304  41.73941 13.74499  1.000 99.07243  ? 39  GLN A N   1 
ATOM   271  C CA  . GLN A 1 39  ? -9.44948  40.65702 14.66631  1.000 90.22172  ? 39  GLN A CA  1 
ATOM   272  C C   . GLN A 1 39  ? -8.52806  41.12600 15.77323  1.000 114.65816 ? 39  GLN A C   1 
ATOM   273  O O   . GLN A 1 39  ? -8.66009  40.69240 16.92465  1.000 124.71723 ? 39  GLN A O   1 
ATOM   274  C CB  . GLN A 1 39  ? -8.79018  39.49814 13.93383  1.000 106.47064 ? 39  GLN A CB  1 
ATOM   275  C CG  . GLN A 1 39  ? -9.69844  38.65361 13.09672  1.000 98.62078  ? 39  GLN A CG  1 
ATOM   276  C CD  . GLN A 1 39  ? -8.92766  37.56987 12.39196  1.000 100.77312 ? 39  GLN A CD  1 
ATOM   277  O OE1 . GLN A 1 39  ? -9.47866  36.52537 12.04895  1.000 94.39636  ? 39  GLN A OE1 1 
ATOM   278  N NE2 . GLN A 1 39  ? -7.63499  37.80896 12.17439  1.000 117.83987 ? 39  GLN A NE2 1 
ATOM   279  N N   . MET A 1 40  ? -7.53779  41.95327 15.43861  1.000 113.18535 ? 40  MET A N   1 
ATOM   280  C CA  . MET A 1 40  ? -6.73332  42.53061 16.50027  1.000 102.64846 ? 40  MET A CA  1 
ATOM   281  C C   . MET A 1 40  ? -7.59793  43.47979 17.31909  1.000 97.04608  ? 40  MET A C   1 
ATOM   282  O O   . MET A 1 40  ? -7.50619  43.50724 18.54982  1.000 104.66641 ? 40  MET A O   1 
ATOM   283  C CB  . MET A 1 40  ? -5.49513  43.23863 15.93632  1.000 117.73705 ? 40  MET A CB  1 
ATOM   284  C CG  . MET A 1 40  ? -5.67628  43.84792 14.55744  1.000 101.68529 ? 40  MET A CG  1 
ATOM   285  S SD  . MET A 1 40  ? -4.18361  43.99373 13.51999  1.000 124.21035 ? 40  MET A SD  1 
ATOM   286  C CE  . MET A 1 40  ? -3.75612  42.29462 13.10061  1.000 91.81380  ? 40  MET A CE  1 
ATOM   287  N N   . LEU A 1 41  ? -8.50485  44.21766 16.64892  1.000 103.80005 ? 41  LEU A N   1 
ATOM   288  C CA  . LEU A 1 41  ? -9.49578  45.03674 17.35738  1.000 117.89614 ? 41  LEU A CA  1 
ATOM   289  C C   . LEU A 1 41  ? -10.42297 44.17841 18.21452  1.000 125.98640 ? 41  LEU A C   1 
ATOM   290  O O   . LEU A 1 41  ? -10.93994 44.65979 19.23034  1.000 121.58984 ? 41  LEU A O   1 
ATOM   291  C CB  . LEU A 1 41  ? -10.31336 45.89379 16.36388  1.000 96.46316  ? 41  LEU A CB  1 
ATOM   292  C CG  . LEU A 1 41  ? -11.86975 46.01599 16.41741  1.000 103.57314 ? 41  LEU A CG  1 
ATOM   293  C CD1 . LEU A 1 41  ? -12.46586 47.13126 17.33478  1.000 102.83115 ? 41  LEU A CD1 1 
ATOM   294  C CD2 . LEU A 1 41  ? -12.46330 46.15415 15.02171  1.000 90.57156  ? 41  LEU A CD2 1 
ATOM   295  N N   . ASN A 1 42  ? -10.62056 42.90617 17.83493  1.000 122.35776 ? 42  ASN A N   1 
ATOM   296  C CA  . ASN A 1 42  ? -11.50523 41.95023 18.50689  1.000 100.32523 ? 42  ASN A CA  1 
ATOM   297  C C   . ASN A 1 42  ? -12.97193 42.35198 18.32148  1.000 103.52464 ? 42  ASN A C   1 
ATOM   298  O O   . ASN A 1 42  ? -13.65460 42.68371 19.30189  1.000 97.61167  ? 42  ASN A O   1 
ATOM   299  C CB  . ASN A 1 42  ? -11.14787 41.80847 20.00671  1.000 84.86175  ? 42  ASN A CB  1 
ATOM   300  C CG  . ASN A 1 42  ? -10.13652 40.68323 20.28410  1.000 86.98905  ? 42  ASN A CG  1 
ATOM   301  O OD1 . ASN A 1 42  ? -10.46961 39.49137 20.27702  1.000 81.21951  ? 42  ASN A OD1 1 
ATOM   302  N ND2 . ASN A 1 42  ? -8.88980  41.07139 20.53337  1.000 95.81726  ? 42  ASN A ND2 1 
ATOM   303  N N   . ALA A 1 43  ? -13.44193 42.33927 17.05465  1.000 108.44523 ? 43  ALA A N   1 
ATOM   304  C CA  . ALA A 1 43  ? -14.85111 42.46639 16.65454  1.000 87.38089  ? 43  ALA A CA  1 
ATOM   305  C C   . ALA A 1 43  ? -15.32602 41.21149 15.93187  1.000 69.01723  ? 43  ALA A C   1 
ATOM   306  O O   . ALA A 1 43  ? -16.20655 40.48970 16.41305  1.000 84.16599  ? 43  ALA A O   1 
ATOM   307  C CB  . ALA A 1 43  ? -15.07030 43.66190 15.72934  1.000 78.64314  ? 43  ALA A CB  1 
ATOM   308  N N   . SER A 1 44  ? -14.76301 40.95534 14.76382  1.000 67.05948  ? 44  SER A N   1 
ATOM   309  C CA  . SER A 1 44  ? -15.09945 39.77031 14.01222  1.000 58.37519  ? 44  SER A CA  1 
ATOM   310  C C   . SER A 1 44  ? -13.87624 38.87383 13.91014  1.000 64.26489  ? 44  SER A C   1 
ATOM   311  O O   . SER A 1 44  ? -12.73487 39.31347 14.05630  1.000 65.32836  ? 44  SER A O   1 
ATOM   312  C CB  . SER A 1 44  ? -15.65113 40.12495 12.61933  1.000 61.28817  ? 44  SER A CB  1 
ATOM   313  O OG  . SER A 1 44  ? -15.04402 41.29049 12.07536  1.000 86.06663  ? 44  SER A OG  1 
ATOM   314  N N   . ARG A 1 45  ? -14.15248 37.59411 13.71389  1.000 65.08361  ? 45  ARG A N   1 
ATOM   315  C CA  . ARG A 1 45  ? -13.15681 36.55073 13.57357  1.000 62.36689  ? 45  ARG A CA  1 
ATOM   316  C C   . ARG A 1 45  ? -13.34750 35.91549 12.20813  1.000 65.64281  ? 45  ARG A C   1 
ATOM   317  O O   . ARG A 1 45  ? -14.46417 35.55156 11.84468  1.000 75.44987  ? 45  ARG A O   1 
ATOM   318  C CB  . ARG A 1 45  ? -13.29905 35.50030 14.66809  1.000 59.64066  ? 45  ARG A CB  1 
ATOM   319  C CG  . ARG A 1 45  ? -12.78475 35.89972 16.04380  1.000 70.59755  ? 45  ARG A CG  1 
ATOM   320  C CD  . ARG A 1 45  ? -11.26161 35.77894 16.12126  1.000 76.60147  ? 45  ARG A CD  1 
ATOM   321  N NE  . ARG A 1 45  ? -10.68105 37.08133 16.39697  1.000 95.99216  ? 45  ARG A NE  1 
ATOM   322  C CZ  . ARG A 1 45  ? -10.26436 37.48595 17.58917  1.000 102.28727 ? 45  ARG A CZ  1 
ATOM   323  N NH1 . ARG A 1 45  ? -10.11418 36.63369 18.59596  1.000 82.54025  ? 45  ARG A NH1 1 
ATOM   324  N NH2 . ARG A 1 45  ? -9.98182  38.77789 17.77222  1.000 103.64390 ? 45  ARG A NH2 1 
ATOM   325  N N   . THR A 1 46  ? -12.26330 35.76968 11.46746  1.000 68.39544  ? 46  THR A N   1 
ATOM   326  C CA  . THR A 1 46  ? -12.30433 35.34480 10.08294  1.000 61.98338  ? 46  THR A CA  1 
ATOM   327  C C   . THR A 1 46  ? -11.70810 33.94991 9.98701   1.000 75.51847  ? 46  THR A C   1 
ATOM   328  O O   . THR A 1 46  ? -10.61785 33.70071 10.50536  1.000 76.89845  ? 46  THR A O   1 
ATOM   329  C CB  . THR A 1 46  ? -11.54908 36.34392 9.22008   1.000 57.58412  ? 46  THR A CB  1 
ATOM   330  O OG1 . THR A 1 46  ? -11.94211 37.67035 9.60425   1.000 59.77498  ? 46  THR A OG1 1 
ATOM   331  C CG2 . THR A 1 46  ? -11.85266 36.12074 7.78135   1.000 73.35099  ? 46  THR A CG2 1 
ATOM   332  N N   . PHE A 1 47  ? -12.43589 33.03226 9.36427   1.000 62.73562  ? 47  PHE A N   1 
ATOM   333  C CA  . PHE A 1 47  ? -11.98094 31.65993 9.21157   1.000 73.77724  ? 47  PHE A CA  1 
ATOM   334  C C   . PHE A 1 47  ? -11.73819 31.39244 7.73561   1.000 69.34796  ? 47  PHE A C   1 
ATOM   335  O O   . PHE A 1 47  ? -12.56524 31.75376 6.89523   1.000 73.33400  ? 47  PHE A O   1 
ATOM   336  C CB  . PHE A 1 47  ? -13.00242 30.67887 9.79777   1.000 61.72643  ? 47  PHE A CB  1 
ATOM   337  C CG  . PHE A 1 47  ? -13.24398 30.88208 11.25969  1.000 54.41995  ? 47  PHE A CG  1 
ATOM   338  C CD1 . PHE A 1 47  ? -14.21104 31.78408 11.70067  1.000 53.80329  ? 47  PHE A CD1 1 
ATOM   339  C CD2 . PHE A 1 47  ? -12.49726 30.18497 12.19790  1.000 53.81677  ? 47  PHE A CD2 1 
ATOM   340  C CE1 . PHE A 1 47  ? -14.42940 31.98920 13.05858  1.000 52.83966  ? 47  PHE A CE1 1 
ATOM   341  C CE2 . PHE A 1 47  ? -12.69801 30.38054 13.54843  1.000 56.32379  ? 47  PHE A CE2 1 
ATOM   342  C CZ  . PHE A 1 47  ? -13.66850 31.28947 13.98488  1.000 59.06973  ? 47  PHE A CZ  1 
ATOM   343  N N   . VAL A 1 48  ? -10.59728 30.78598 7.41961   1.000 66.07474  ? 48  VAL A N   1 
ATOM   344  C CA  . VAL A 1 48  ? -10.17346 30.62659 6.03545   1.000 66.96261  ? 48  VAL A CA  1 
ATOM   345  C C   . VAL A 1 48  ? -9.85170  29.15907 5.78320   1.000 78.66220  ? 48  VAL A C   1 
ATOM   346  O O   . VAL A 1 48  ? -9.51880  28.39945 6.69970   1.000 82.51883  ? 48  VAL A O   1 
ATOM   347  C CB  . VAL A 1 48  ? -8.95299  31.51808 5.69765   1.000 67.23636  ? 48  VAL A CB  1 
ATOM   348  C CG1 . VAL A 1 48  ? -9.21215  32.95678 6.07143   1.000 61.47729  ? 48  VAL A CG1 1 
ATOM   349  C CG2 . VAL A 1 48  ? -7.70922  31.01187 6.40291   1.000 66.04930  ? 48  VAL A CG2 1 
ATOM   350  N N   . ILE A 1 49  ? -9.96924  28.75508 4.52012   1.000 83.53672  ? 49  ILE A N   1 
ATOM   351  C CA  . ILE A 1 49  ? -9.53384  27.42349 4.10947   1.000 96.55733  ? 49  ILE A CA  1 
ATOM   352  C C   . ILE A 1 49  ? -8.47690  27.58211 3.02798   1.000 90.27654  ? 49  ILE A C   1 
ATOM   353  O O   . ILE A 1 49  ? -8.43232  28.58302 2.30283   1.000 85.89108  ? 49  ILE A O   1 
ATOM   354  C CB  . ILE A 1 49  ? -10.68055 26.51393 3.60326   1.000 87.76679  ? 49  ILE A CB  1 
ATOM   355  C CG1 . ILE A 1 49  ? -11.62849 27.26188 2.66609   1.000 81.15025  ? 49  ILE A CG1 1 
ATOM   356  C CG2 . ILE A 1 49  ? -11.46185 25.98400 4.77097   1.000 78.85664  ? 49  ILE A CG2 1 
ATOM   357  C CD1 . ILE A 1 49  ? -12.32269 26.34317 1.68372   1.000 74.61953  ? 49  ILE A CD1 1 
ATOM   358  N N   . CYS A 1 50  ? -7.61505  26.58637 2.92128   1.000 83.56146  ? 50  CYS A N   1 
ATOM   359  C CA  . CYS A 1 50  ? -6.48530  26.68990 2.01413   1.000 99.91689  ? 50  CYS A CA  1 
ATOM   360  C C   . CYS A 1 50  ? -6.48025  25.50070 1.06440   1.000 115.75618 ? 50  CYS A C   1 
ATOM   361  O O   . CYS A 1 50  ? -7.32422  24.60233 1.15815   1.000 102.19319 ? 50  CYS A O   1 
ATOM   362  C CB  . CYS A 1 50  ? -5.17824  26.80490 2.80771   1.000 81.63668  ? 50  CYS A CB  1 
ATOM   363  S SG  . CYS A 1 50  ? -5.16876  28.27632 3.84652   1.000 84.29948  ? 50  CYS A SG  1 
ATOM   364  N N   . LEU A 1 51  ? -5.55427  25.53605 0.10661   1.000 100.46576 ? 51  LEU A N   1 
ATOM   365  C CA  . LEU A 1 51  ? -5.28133  24.36252 -0.70871  1.000 92.30746  ? 51  LEU A CA  1 
ATOM   366  C C   . LEU A 1 51  ? -4.33435  23.43064 0.03910   1.000 93.60173  ? 51  LEU A C   1 
ATOM   367  O O   . LEU A 1 51  ? -3.40468  23.88462 0.70954   1.000 97.53613  ? 51  LEU A O   1 
ATOM   368  C CB  . LEU A 1 51  ? -4.68462  24.77319 -2.05673  1.000 89.72495  ? 51  LEU A CB  1 
ATOM   369  N N   . GLU A 1 52  ? -4.59450  22.11844 -0.07226  1.000 101.70116 ? 52  GLU A N   1 
ATOM   370  C CA  . GLU A 1 52  ? -3.85789  21.09538 0.68017   1.000 99.64533  ? 52  GLU A CA  1 
ATOM   371  C C   . GLU A 1 52  ? -2.35109  21.24922 0.48452   1.000 96.85381  ? 52  GLU A C   1 
ATOM   372  O O   . GLU A 1 52  ? -1.87958  21.49946 -0.62623  1.000 107.29850 ? 52  GLU A O   1 
ATOM   373  C CB  . GLU A 1 52  ? -4.29958  19.68701 0.24636   1.000 96.08851  ? 52  GLU A CB  1 
ATOM   374  C CG  . GLU A 1 52  ? -3.64370  18.51263 1.01361   1.000 99.45134  ? 52  GLU A CG  1 
ATOM   375  C CD  . GLU A 1 52  ? -3.77348  17.15333 0.30075   1.000 115.69011 ? 52  GLU A CD  1 
ATOM   376  O OE1 . GLU A 1 52  ? -3.35845  17.05395 -0.87579  1.000 116.34278 ? 52  GLU A OE1 1 
ATOM   377  O OE2 . GLU A 1 52  ? -4.25730  16.17484 0.91902   1.000 96.91639  ? 52  GLU A OE2 1 
ATOM   378  N N   . ASP A 1 53  ? -1.59400  21.10213 1.57600   1.000 100.58907 ? 53  ASP A N   1 
ATOM   379  C CA  . ASP A 1 53  ? -0.13574  21.21711 1.65011   1.000 105.73547 ? 53  ASP A CA  1 
ATOM   380  C C   . ASP A 1 53  ? 0.35988   22.63019 1.31371   1.000 99.07587  ? 53  ASP A C   1 
ATOM   381  O O   . ASP A 1 53  ? 1.57597   22.84713 1.28330   1.000 101.87893 ? 53  ASP A O   1 
ATOM   382  C CB  . ASP A 1 53  ? 0.58408   20.18505 0.75323   1.000 116.66708 ? 53  ASP A CB  1 
ATOM   383  C CG  . ASP A 1 53  ? 0.58753   18.74362 1.35173   1.000 123.93117 ? 53  ASP A CG  1 
ATOM   384  O OD1 . ASP A 1 53  ? 1.35456   18.47854 2.30929   1.000 130.66350 ? 53  ASP A OD1 1 
ATOM   385  O OD2 . ASP A 1 53  ? -0.18739  17.87410 0.86251   1.000 103.34871 ? 53  ASP A OD2 1 
ATOM   386  N N   . THR A 1 54  ? -0.53306  23.59302 1.07281   1.000 94.87218  ? 54  THR A N   1 
ATOM   387  C CA  . THR A 1 54  ? -0.20770  24.99513 0.84431   1.000 95.39815  ? 54  THR A CA  1 
ATOM   388  C C   . THR A 1 54  ? -0.86228  25.86704 1.92001   1.000 104.67329 ? 54  THR A C   1 
ATOM   389  O O   . THR A 1 54  ? -1.51888  25.37012 2.83688   1.000 94.85153  ? 54  THR A O   1 
ATOM   390  C CB  . THR A 1 54  ? -0.64111  25.44320 -0.56137  1.000 92.83299  ? 54  THR A CB  1 
ATOM   391  O OG1 . THR A 1 54  ? -1.99437  25.91614 -0.52647  1.000 90.27323  ? 54  THR A OG1 1 
ATOM   392  C CG2 . THR A 1 54  ? -0.54621  24.29487 -1.55092  1.000 85.35818  ? 54  THR A CG2 1 
ATOM   393  N N   . LEU A 1 55  ? -0.65259  27.18688 1.80831   1.000 111.55606 ? 55  LEU A N   1 
ATOM   394  C CA  . LEU A 1 55  ? -1.35375  28.17555 2.62345   1.000 89.78707  ? 55  LEU A CA  1 
ATOM   395  C C   . LEU A 1 55  ? -2.14112  29.13972 1.75668   1.000 77.14404  ? 55  LEU A C   1 
ATOM   396  O O   . LEU A 1 55  ? -2.55244  30.20215 2.23777   1.000 84.54352  ? 55  LEU A O   1 
ATOM   397  C CB  . LEU A 1 55  ? -0.37865  28.96135 3.50378   1.000 87.95528  ? 55  LEU A CB  1 
ATOM   398  C CG  . LEU A 1 55  ? -0.33129  28.59241 4.98167   1.000 73.69263  ? 55  LEU A CG  1 
ATOM   399  C CD1 . LEU A 1 55  ? 0.39223   27.27184 5.15196   1.000 90.75107  ? 55  LEU A CD1 1 
ATOM   400  C CD2 . LEU A 1 55  ? 0.35914   29.66929 5.76758   1.000 77.84042  ? 55  LEU A CD2 1 
ATOM   401  N N   . ARG A 1 56  ? -2.33605  28.80537 0.48696   1.000 76.52144  ? 56  ARG A N   1 
ATOM   402  C CA  . ARG A 1 56  ? -3.08035  29.66266 -0.42207  1.000 91.56810  ? 56  ARG A CA  1 
ATOM   403  C C   . ARG A 1 56  ? -4.57128  29.58597 -0.10042  1.000 93.47345  ? 56  ARG A C   1 
ATOM   404  O O   . ARG A 1 56  ? -5.21491  28.55208 -0.31643  1.000 89.25645  ? 56  ARG A O   1 
ATOM   405  C CB  . ARG A 1 56  ? -2.79586  29.25697 -1.86174  1.000 74.34321  ? 56  ARG A CB  1 
ATOM   406  C CG  . ARG A 1 56  ? -3.58665  30.06994 -2.83753  1.000 79.15134  ? 56  ARG A CG  1 
ATOM   407  C CD  . ARG A 1 56  ? -4.28502  29.16236 -3.82781  1.000 92.84801  ? 56  ARG A CD  1 
ATOM   408  N NE  . ARG A 1 56  ? -4.92756  29.91408 -4.89925  1.000 91.49523  ? 56  ARG A NE  1 
ATOM   409  C CZ  . ARG A 1 56  ? -6.06791  30.58236 -4.78137  1.000 101.14372 ? 56  ARG A CZ  1 
ATOM   410  N NH1 . ARG A 1 56  ? -6.77981  30.54745 -3.66403  1.000 99.05522  ? 56  ARG A NH1 1 
ATOM   411  N NH2 . ARG A 1 56  ? -6.52062  31.28132 -5.82225  1.000 104.81310 ? 56  ARG A NH2 1 
ATOM   412  N N   . ILE A 1 57  ? -5.11429  30.68758 0.41996   1.000 78.63545  ? 57  ILE A N   1 
ATOM   413  C CA  . ILE A 1 57  ? -6.51941  30.73502 0.79355   1.000 75.73224  ? 57  ILE A CA  1 
ATOM   414  C C   . ILE A 1 57  ? -7.38679  30.48884 -0.43341  1.000 79.46499  ? 57  ILE A C   1 
ATOM   415  O O   . ILE A 1 57  ? -7.13244  31.02673 -1.51563  1.000 77.10199  ? 57  ILE A O   1 
ATOM   416  C CB  . ILE A 1 57  ? -6.84942  32.08497 1.45751   1.000 82.89836  ? 57  ILE A CB  1 
ATOM   417  C CG1 . ILE A 1 57  ? -6.64749  31.99357 2.95937   1.000 71.47658  ? 57  ILE A CG1 1 
ATOM   418  C CG2 . ILE A 1 57  ? -8.28007  32.53628 1.14066   1.000 73.44761  ? 57  ILE A CG2 1 
ATOM   419  C CD1 . ILE A 1 57  ? -5.25373  31.84191 3.35425   1.000 84.78182  ? 57  ILE A CD1 1 
ATOM   420  N N   . VAL A 1 58  ? -8.41924  29.66386 -0.26729  1.000 87.89901  ? 58  VAL A N   1 
ATOM   421  C CA  . VAL A 1 58  ? -9.37452  29.39340 -1.33734  1.000 85.02525  ? 58  VAL A CA  1 
ATOM   422  C C   . VAL A 1 58  ? -10.82169 29.69455 -0.94096  1.000 79.60822  ? 58  VAL A C   1 
ATOM   423  O O   . VAL A 1 58  ? -11.69258 29.71322 -1.82310  1.000 71.22534  ? 58  VAL A O   1 
ATOM   424  C CB  . VAL A 1 58  ? -9.23226  27.94020 -1.84310  1.000 86.13077  ? 58  VAL A CB  1 
ATOM   425  C CG1 . VAL A 1 58  ? -8.06563  27.83526 -2.82436  1.000 90.30870  ? 58  VAL A CG1 1 
ATOM   426  C CG2 . VAL A 1 58  ? -8.96892  27.00771 -0.68688  1.000 77.90291  ? 58  VAL A CG2 1 
ATOM   427  N N   . GLY A 1 59  ? -11.09655 29.97634 0.33872   1.000 82.86840  ? 59  GLY A N   1 
ATOM   428  C CA  . GLY A 1 59  ? -12.42275 30.35040 0.81511   1.000 67.82958  ? 59  GLY A CA  1 
ATOM   429  C C   . GLY A 1 59  ? -12.35309 30.83501 2.24857   1.000 74.51827  ? 59  GLY A C   1 
ATOM   430  O O   . GLY A 1 59  ? -11.39306 30.53760 2.97044   1.000 71.64974  ? 59  GLY A O   1 
ATOM   431  N N   . TYR A 1 60  ? -13.37934 31.59794 2.66021   1.000 65.45086  ? 60  TYR A N   1 
ATOM   432  C CA  . TYR A 1 60  ? -13.38355 32.17161 4.00980   1.000 62.12465  ? 60  TYR A CA  1 
ATOM   433  C C   . TYR A 1 60  ? -14.77813 32.65383 4.43354   1.000 63.57229  ? 60  TYR A C   1 
ATOM   434  O O   . TYR A 1 60  ? -15.65778 32.90165 3.59946   1.000 58.06651  ? 60  TYR A O   1 
ATOM   435  C CB  . TYR A 1 60  ? -12.36839 33.31899 4.11971   1.000 61.14793  ? 60  TYR A CB  1 
ATOM   436  C CG  . TYR A 1 60  ? -12.92254 34.66697 3.71623   1.000 69.85284  ? 60  TYR A CG  1 
ATOM   437  C CD1 . TYR A 1 60  ? -12.90091 35.07501 2.38641   1.000 62.58769  ? 60  TYR A CD1 1 
ATOM   438  C CD2 . TYR A 1 60  ? -13.48449 35.52786 4.67076   1.000 60.74228  ? 60  TYR A CD2 1 
ATOM   439  C CE1 . TYR A 1 60  ? -13.42627 36.29770 2.01697   1.000 71.12120  ? 60  TYR A CE1 1 
ATOM   440  C CE2 . TYR A 1 60  ? -14.00855 36.74669 4.31417   1.000 64.02617  ? 60  TYR A CE2 1 
ATOM   441  C CZ  . TYR A 1 60  ? -13.97660 37.13583 2.98619   1.000 78.05092  ? 60  TYR A CZ  1 
ATOM   442  O OH  . TYR A 1 60  ? -14.49071 38.36322 2.60969   1.000 81.94173  ? 60  TYR A OH  1 
ATOM   443  N N   . TYR A 1 61  ? -14.94827 32.81526 5.76110   1.000 69.28246  ? 61  TYR A N   1 
ATOM   444  C CA  . TYR A 1 61  ? -16.15689 33.37253 6.38154   1.000 57.11632  ? 61  TYR A CA  1 
ATOM   445  C C   . TYR A 1 61  ? -15.79943 34.13845 7.65316   1.000 57.79076  ? 61  TYR A C   1 
ATOM   446  O O   . TYR A 1 61  ? -14.71405 33.97195 8.21553   1.000 58.94251  ? 61  TYR A O   1 
ATOM   447  C CB  . TYR A 1 61  ? -17.21003 32.28222 6.67778   1.000 55.90878  ? 61  TYR A CB  1 
ATOM   448  C CG  . TYR A 1 61  ? -16.98297 31.30664 7.82340   1.000 49.35594  ? 61  TYR A CG  1 
ATOM   449  C CD1 . TYR A 1 61  ? -17.32382 31.62825 9.13643   1.000 45.82629  ? 61  TYR A CD1 1 
ATOM   450  C CD2 . TYR A 1 61  ? -16.49451 30.02760 7.57290   1.000 57.03578  ? 61  TYR A CD2 1 
ATOM   451  C CE1 . TYR A 1 61  ? -17.15050 30.71239 10.17841  1.000 47.07441  ? 61  TYR A CE1 1 
ATOM   452  C CE2 . TYR A 1 61  ? -16.31679 29.10033 8.60146   1.000 59.38873  ? 61  TYR A CE2 1 
ATOM   453  C CZ  . TYR A 1 61  ? -16.64038 29.44337 9.91214   1.000 56.67498  ? 61  TYR A CZ  1 
ATOM   454  O OH  . TYR A 1 61  ? -16.45083 28.51138 10.92365  1.000 52.99987  ? 61  TYR A OH  1 
ATOM   455  N N   . SER A 1 62  ? -16.73663 34.98374 8.11592   1.000 57.69793  ? 62  SER A N   1 
ATOM   456  C CA  . SER A 1 62  ? -16.50539 35.80915 9.29889   1.000 58.79267  ? 62  SER A CA  1 
ATOM   457  C C   . SER A 1 62  ? -17.66554 35.71236 10.29504  1.000 52.54461  ? 62  SER A C   1 
ATOM   458  O O   . SER A 1 62  ? -18.80331 35.42397 9.92147   1.000 65.18081  ? 62  SER A O   1 
ATOM   459  C CB  . SER A 1 62  ? -16.25303 37.26929 8.89701   1.000 57.75331  ? 62  SER A CB  1 
ATOM   460  O OG  . SER A 1 62  ? -17.40777 38.07684 9.04672   1.000 88.79142  ? 62  SER A OG  1 
ATOM   461  N N   . LEU A 1 63  ? -17.36933 36.01298 11.56612  1.000 48.68447  ? 63  LEU A N   1 
ATOM   462  C CA  . LEU A 1 63  ? -18.25284 35.78536 12.70843  1.000 50.97382  ? 63  LEU A CA  1 
ATOM   463  C C   . LEU A 1 63  ? -18.07444 36.86289 13.77602  1.000 55.73465  ? 63  LEU A C   1 
ATOM   464  O O   . LEU A 1 63  ? -17.00506 36.97722 14.38502  1.000 49.83721  ? 63  LEU A O   1 
ATOM   465  C CB  . LEU A 1 63  ? -17.97980 34.41122 13.34895  1.000 44.32532  ? 63  LEU A CB  1 
ATOM   466  C CG  . LEU A 1 63  ? -18.66969 33.21533 12.70831  1.000 51.56640  ? 63  LEU A CG  1 
ATOM   467  C CD1 . LEU A 1 63  ? -18.45300 31.93728 13.48487  1.000 40.12629  ? 63  LEU A CD1 1 
ATOM   468  C CD2 . LEU A 1 63  ? -20.15286 33.52895 12.57552  1.000 56.53030  ? 63  LEU A CD2 1 
ATOM   469  N N   . ALA A 1 64  ? -19.13328 37.61452 14.04480  1.000 48.81344  ? 64  ALA A N   1 
ATOM   470  C CA  . ALA A 1 64  ? -19.12884 38.53470 15.16347  1.000 47.53009  ? 64  ALA A CA  1 
ATOM   471  C C   . ALA A 1 64  ? -20.44800 38.40275 15.90187  1.000 44.17705  ? 64  ALA A C   1 
ATOM   472  O O   . ALA A 1 64  ? -21.46079 38.01618 15.31716  1.000 59.03330  ? 64  ALA A O   1 
ATOM   473  C CB  . ALA A 1 64  ? -18.93816 39.97359 14.70952  1.000 48.70984  ? 64  ALA A CB  1 
ATOM   474  N N   . THR A 1 65  ? -20.43836 38.72865 17.18637  1.000 47.59329  ? 65  THR A N   1 
ATOM   475  C CA  . THR A 1 65  ? -21.67876 38.76884 17.92885  1.000 50.96848  ? 65  THR A CA  1 
ATOM   476  C C   . THR A 1 65  ? -22.45500 40.05196 17.62559  1.000 68.45395  ? 65  THR A C   1 
ATOM   477  O O   . THR A 1 65  ? -21.96509 40.97491 16.96241  1.000 75.20638  ? 65  THR A O   1 
ATOM   478  C CB  . THR A 1 65  ? -21.40997 38.68242 19.41706  1.000 44.30949  ? 65  THR A CB  1 
ATOM   479  O OG1 . THR A 1 65  ? -21.05639 39.98208 19.89576  1.000 44.41949  ? 65  THR A OG1 1 
ATOM   480  C CG2 . THR A 1 65  ? -20.28446 37.77764 19.65187  1.000 46.08594  ? 65  THR A CG2 1 
ATOM   481  N N   . GLY A 1 66  ? -23.68801 40.08902 18.12335  1.000 56.19602  ? 66  GLY A N   1 
ATOM   482  C CA  . GLY A 1 66  ? -24.60835 41.15818 17.82972  1.000 55.55353  ? 66  GLY A CA  1 
ATOM   483  C C   . GLY A 1 66  ? -25.74750 41.14199 18.81835  1.000 53.81405  ? 66  GLY A C   1 
ATOM   484  O O   . GLY A 1 66  ? -25.76567 40.33800 19.74945  1.000 71.06668  ? 66  GLY A O   1 
ATOM   485  N N   . SER A 1 67  ? -26.70483 42.04388 18.62274  1.000 53.46966  ? 67  SER A N   1 
ATOM   486  C CA  . SER A 1 67  ? -27.83046 42.06747 19.54655  1.000 59.34735  ? 67  SER A CA  1 
ATOM   487  C C   . SER A 1 67  ? -29.01728 42.72134 18.84882  1.000 64.24312  ? 67  SER A C   1 
ATOM   488  O O   . SER A 1 67  ? -28.86714 43.38800 17.82058  1.000 63.44626  ? 67  SER A O   1 
ATOM   489  C CB  . SER A 1 67  ? -27.44679 42.78428 20.84861  1.000 54.76891  ? 67  SER A CB  1 
ATOM   490  O OG  . SER A 1 67  ? -28.56264 42.98484 21.68888  1.000 73.57030  ? 67  SER A OG  1 
ATOM   491  N N   . VAL A 1 68  ? -30.20914 42.46384 19.38547  1.000 68.23478  ? 68  VAL A N   1 
ATOM   492  C CA  . VAL A 1 68  ? -31.44545 43.07773 18.91036  1.000 66.58532  ? 68  VAL A CA  1 
ATOM   493  C C   . VAL A 1 68  ? -32.18716 43.58044 20.13303  1.000 67.76647  ? 68  VAL A C   1 
ATOM   494  O O   . VAL A 1 68  ? -32.37597 42.82930 21.09736  1.000 66.50329  ? 68  VAL A O   1 
ATOM   495  C CB  . VAL A 1 68  ? -32.33245 42.09964 18.10707  1.000 75.31522  ? 68  VAL A CB  1 
ATOM   496  C CG1 . VAL A 1 68  ? -33.49654 42.84041 17.43673  1.000 65.50219  ? 68  VAL A CG1 1 
ATOM   497  C CG2 . VAL A 1 68  ? -31.51504 41.32206 17.07313  1.000 59.98267  ? 68  VAL A CG2 1 
ATOM   498  N N   . THR A 1 69  ? -32.58212 44.85210 20.11173  1.000 72.42924  ? 69  THR A N   1 
ATOM   499  C CA  . THR A 1 69  ? -33.29693 45.43496 21.23991  1.000 88.18785  ? 69  THR A CA  1 
ATOM   500  C C   . THR A 1 69  ? -34.35281 46.38780 20.68915  1.000 88.93568  ? 69  THR A C   1 
ATOM   501  O O   . THR A 1 69  ? -34.43002 46.62339 19.47752  1.000 84.46985  ? 69  THR A O   1 
ATOM   502  C CB  . THR A 1 69  ? -32.31589 46.11445 22.20752  1.000 80.48412  ? 69  THR A CB  1 
ATOM   503  O OG1 . THR A 1 69  ? -32.98524 46.43993 23.43397  1.000 78.47988  ? 69  THR A OG1 1 
ATOM   504  C CG2 . THR A 1 69  ? -31.72815 47.38188 21.59158  1.000 75.05316  ? 69  THR A CG2 1 
ATOM   505  N N   . HIS A 1 70  ? -35.19390 46.91020 21.57599  1.000 86.34224  ? 70  HIS A N   1 
ATOM   506  C CA  . HIS A 1 70  ? -36.17512 47.91884 21.20846  1.000 88.43781  ? 70  HIS A CA  1 
ATOM   507  C C   . HIS A 1 70  ? -35.64772 49.30225 21.55341  1.000 95.68944  ? 70  HIS A C   1 
ATOM   508  O O   . HIS A 1 70  ? -34.60116 49.46521 22.18599  1.000 92.17379  ? 70  HIS A O   1 
ATOM   509  C CB  . HIS A 1 70  ? -37.48816 47.67553 21.93469  1.000 84.15534  ? 70  HIS A CB  1 
ATOM   510  C CG  . HIS A 1 70  ? -37.28964 47.19754 23.33304  1.000 101.76452 ? 70  HIS A CG  1 
ATOM   511  N ND1 . HIS A 1 70  ? -36.44053 47.83293 24.21789  1.000 113.69935 ? 70  HIS A ND1 1 
ATOM   512  C CD2 . HIS A 1 70  ? -37.78409 46.12084 23.99016  1.000 105.29787 ? 70  HIS A CD2 1 
ATOM   513  C CE1 . HIS A 1 70  ? -36.44688 47.18444 25.37006  1.000 113.02764 ? 70  HIS A CE1 1 
ATOM   514  N NE2 . HIS A 1 70  ? -37.24870 46.13829 25.25663  1.000 115.61427 ? 70  HIS A NE2 1 
ATOM   515  N N   . ALA A 1 71  ? -36.40859 50.30648 21.15581  1.000 96.95522  ? 71  ALA A N   1 
ATOM   516  C CA  . ALA A 1 71  ? -36.10841 51.68830 21.50230  1.000 100.63791 ? 71  ALA A CA  1 
ATOM   517  C C   . ALA A 1 71  ? -36.93163 52.02023 22.73829  1.000 111.39124 ? 71  ALA A C   1 
ATOM   518  O O   . ALA A 1 71  ? -38.12941 52.30439 22.63100  1.000 111.80655 ? 71  ALA A O   1 
ATOM   519  C CB  . ALA A 1 71  ? -36.42929 52.61557 20.33887  1.000 85.20467  ? 71  ALA A CB  1 
ATOM   520  N N   . GLU A 1 72  ? -36.28645 51.95321 23.90780  1.000 107.12908 ? 72  GLU A N   1 
ATOM   521  C CA  . GLU A 1 72  ? -36.91263 52.25019 25.19504  1.000 104.64393 ? 72  GLU A CA  1 
ATOM   522  C C   . GLU A 1 72  ? -38.40545 51.87067 25.26908  1.000 98.56424  ? 72  GLU A C   1 
ATOM   523  O O   . GLU A 1 72  ? -38.80812 50.98801 26.02067  1.000 95.48001  ? 72  GLU A O   1 
ATOM   524  C CB  . GLU A 1 72  ? -36.74257 53.73154 25.49975  1.000 113.19548 ? 72  GLU A CB  1 
ATOM   525  C CG  . GLU A 1 72  ? -37.75962 54.29128 26.47634  1.000 111.54557 ? 72  GLU A CG  1 
ATOM   526  C CD  . GLU A 1 72  ? -38.20300 55.70870 26.12492  1.000 118.66789 ? 72  GLU A CD  1 
ATOM   527  O OE1 . GLU A 1 72  ? -39.38928 55.88501 25.75726  1.000 115.96846 ? 72  GLU A OE1 1 
ATOM   528  O OE2 . GLU A 1 72  ? -37.34593 56.64096 26.21061  1.000 125.88105 ? 72  GLU A OE2 1 
ATOM   529  N N   . PRO A 1 82  ? -33.26294 37.69734 26.44946  1.000 73.67053  ? 82  PRO A N   1 
ATOM   530  C CA  . PRO A 1 82  ? -34.48065 38.46262 26.69524  1.000 76.48109  ? 82  PRO A CA  1 
ATOM   531  C C   . PRO A 1 82  ? -34.37008 39.86749 26.12701  1.000 92.96632  ? 82  PRO A C   1 
ATOM   532  O O   . PRO A 1 82  ? -34.44510 39.98616 24.90537  1.000 105.51521 ? 82  PRO A O   1 
ATOM   533  C CB  . PRO A 1 82  ? -34.58107 38.49667 28.22299  1.000 89.43143  ? 82  PRO A CB  1 
ATOM   534  C CG  . PRO A 1 82  ? -33.84277 37.29365 28.67425  1.000 96.34206  ? 82  PRO A CG  1 
ATOM   535  C CD  . PRO A 1 82  ? -32.71579 37.13443 27.69349  1.000 92.90305  ? 82  PRO A CD  1 
ATOM   536  N N   . ASN A 1 83  ? -34.15675 40.88477 26.98139  1.000 112.82049 ? 83  ASN A N   1 
ATOM   537  C CA  . ASN A 1 83  ? -34.27168 42.29356 26.57758  1.000 111.67155 ? 83  ASN A CA  1 
ATOM   538  C C   . ASN A 1 83  ? -33.36464 42.66371 25.40530  1.000 96.39772  ? 83  ASN A C   1 
ATOM   539  O O   . ASN A 1 83  ? -33.87295 43.19055 24.39977  1.000 95.12103  ? 83  ASN A O   1 
ATOM   540  C CB  . ASN A 1 83  ? -34.02747 43.20686 27.79721  1.000 106.93426 ? 83  ASN A CB  1 
ATOM   541  C CG  . ASN A 1 83  ? -33.97461 44.71009 27.43032  1.000 113.08150 ? 83  ASN A CG  1 
ATOM   542  O OD1 . ASN A 1 83  ? -35.01348 45.35278 27.27874  1.000 116.07704 ? 83  ASN A OD1 1 
ATOM   543  N ND2 . ASN A 1 83  ? -32.76303 45.26713 27.30451  1.000 96.91536  ? 83  ASN A ND2 1 
ATOM   544  N N   . PRO A 1 84  ? -32.05842 42.45990 25.46011  1.000 80.57752  ? 84  PRO A N   1 
ATOM   545  C CA  . PRO A 1 84  ? -31.31753 42.36877 24.19934  1.000 82.99598  ? 84  PRO A CA  1 
ATOM   546  C C   . PRO A 1 84  ? -31.25386 40.90970 23.79042  1.000 63.96288  ? 84  PRO A C   1 
ATOM   547  O O   . PRO A 1 84  ? -31.04263 40.01495 24.61075  1.000 63.72323  ? 84  PRO A O   1 
ATOM   548  C CB  . PRO A 1 84  ? -29.94486 42.96616 24.54144  1.000 68.34994  ? 84  PRO A CB  1 
ATOM   549  C CG  . PRO A 1 84  ? -29.99048 43.28423 26.02981  1.000 71.90520  ? 84  PRO A CG  1 
ATOM   550  C CD  . PRO A 1 84  ? -31.14355 42.54959 26.60695  1.000 70.84976  ? 84  PRO A CD  1 
ATOM   551  N N   . VAL A 1 85  ? -31.50736 40.63115 22.52040  1.000 61.52600  ? 85  VAL A N   1 
ATOM   552  C CA  . VAL A 1 85  ? -31.56395 39.25578 22.04028  1.000 57.56223  ? 85  VAL A CA  1 
ATOM   553  C C   . VAL A 1 85  ? -30.17044 38.89111 21.51946  1.000 53.65062  ? 85  VAL A C   1 
ATOM   554  O O   . VAL A 1 85  ? -29.69015 39.53232 20.57900  1.000 59.71651  ? 85  VAL A O   1 
ATOM   555  C CB  . VAL A 1 85  ? -32.63607 39.09524 20.96319  1.000 66.95444  ? 85  VAL A CB  1 
ATOM   556  C CG1 . VAL A 1 85  ? -32.91247 37.64982 20.73408  1.000 69.62452  ? 85  VAL A CG1 1 
ATOM   557  C CG2 . VAL A 1 85  ? -33.92152 39.78985 21.40666  1.000 75.56433  ? 85  VAL A CG2 1 
ATOM   558  N N   . PRO A 1 86  ? -29.50257 37.91044 22.11965  1.000 57.57276  ? 86  PRO A N   1 
ATOM   559  C CA  . PRO A 1 86  ? -28.10305 37.64233 21.76492  1.000 48.47169  ? 86  PRO A CA  1 
ATOM   560  C C   . PRO A 1 86  ? -28.01277 36.79634 20.50519  1.000 47.36575  ? 86  PRO A C   1 
ATOM   561  O O   . PRO A 1 86  ? -28.57834 35.70783 20.43251  1.000 51.73689  ? 86  PRO A O   1 
ATOM   562  C CB  . PRO A 1 86  ? -27.58234 36.89314 22.99514  1.000 49.57245  ? 86  PRO A CB  1 
ATOM   563  C CG  . PRO A 1 86  ? -28.78152 36.20386 23.53701  1.000 53.56329  ? 86  PRO A CG  1 
ATOM   564  C CD  . PRO A 1 86  ? -29.95273 37.10594 23.26932  1.000 59.98204  ? 86  PRO A CD  1 
ATOM   565  N N   . VAL A 1 87  ? -27.29038 37.30068 19.50627  1.000 57.06814  ? 87  VAL A N   1 
ATOM   566  C CA  . VAL A 1 87  ? -27.18690 36.66042 18.19255  1.000 53.02776  ? 87  VAL A CA  1 
ATOM   567  C C   . VAL A 1 87  ? -25.73475 36.64526 17.72177  1.000 54.31160  ? 87  VAL A C   1 
ATOM   568  O O   . VAL A 1 87  ? -24.82168 37.14120 18.39127  1.000 53.74374  ? 87  VAL A O   1 
ATOM   569  C CB  . VAL A 1 87  ? -28.04113 37.37091 17.13409  1.000 52.25761  ? 87  VAL A CB  1 
ATOM   570  C CG1 . VAL A 1 87  ? -29.42264 37.64306 17.66988  1.000 69.14478  ? 87  VAL A CG1 1 
ATOM   571  C CG2 . VAL A 1 87  ? -27.37658 38.67482 16.77951  1.000 55.76907  ? 87  VAL A CG2 1 
ATOM   572  N N   . VAL A 1 88  ? -25.54381 36.11599 16.51913  1.000 50.81613  ? 88  VAL A N   1 
ATOM   573  C CA  . VAL A 1 88  ? -24.22872 36.02983 15.90331  1.000 52.72391  ? 88  VAL A CA  1 
ATOM   574  C C   . VAL A 1 88  ? -24.36899 36.31278 14.41446  1.000 59.36443  ? 88  VAL A C   1 
ATOM   575  O O   . VAL A 1 88  ? -25.11649 35.62383 13.71269  1.000 55.35191  ? 88  VAL A O   1 
ATOM   576  C CB  . VAL A 1 88  ? -23.59040 34.64978 16.12460  1.000 51.64312  ? 88  VAL A CB  1 
ATOM   577  C CG1 . VAL A 1 88  ? -22.60417 34.34631 15.01433  1.000 54.95362  ? 88  VAL A CG1 1 
ATOM   578  C CG2 . VAL A 1 88  ? -22.92416 34.60074 17.48923  1.000 50.37313  ? 88  VAL A CG2 1 
ATOM   579  N N   . LEU A 1 89  ? -23.63517 37.30811 13.92549  1.000 59.50975  ? 89  LEU A N   1 
ATOM   580  C CA  . LEU A 1 89  ? -23.70541 37.69908 12.52979  1.000 60.64936  ? 89  LEU A CA  1 
ATOM   581  C C   . LEU A 1 89  ? -22.68900 36.92008 11.72475  1.000 59.29959  ? 89  LEU A C   1 
ATOM   582  O O   . LEU A 1 89  ? -21.52833 36.80967 12.12386  1.000 66.69211  ? 89  LEU A O   1 
ATOM   583  C CB  . LEU A 1 89  ? -23.47759 39.19528 12.36187  1.000 68.76270  ? 89  LEU A CB  1 
ATOM   584  C CG  . LEU A 1 89  ? -24.71880 39.86431 12.96520  1.000 78.74909  ? 89  LEU A CG  1 
ATOM   585  C CD1 . LEU A 1 89  ? -24.48638 40.31100 14.40963  1.000 66.38965  ? 89  LEU A CD1 1 
ATOM   586  C CD2 . LEU A 1 89  ? -25.23401 40.98658 12.07420  1.000 89.79739  ? 89  LEU A CD2 1 
ATOM   587  N N   . LEU A 1 90  ? -23.14394 36.34699 10.61582  1.000 56.10140  ? 90  LEU A N   1 
ATOM   588  C CA  . LEU A 1 90  ? -22.26648 35.73780 9.61679   1.000 61.26015  ? 90  LEU A CA  1 
ATOM   589  C C   . LEU A 1 90  ? -22.03939 36.80877 8.56526   1.000 72.64293  ? 90  LEU A C   1 
ATOM   590  O O   . LEU A 1 90  ? -22.88820 37.03416 7.70519   1.000 95.33061  ? 90  LEU A O   1 
ATOM   591  C CB  . LEU A 1 90  ? -22.90322 34.48400 9.02414   1.000 65.88964  ? 90  LEU A CB  1 
ATOM   592  C CG  . LEU A 1 90  ? -22.16534 33.84673 7.83256   1.000 62.41460  ? 90  LEU A CG  1 
ATOM   593  C CD1 . LEU A 1 90  ? -20.86420 33.14852 8.24757   1.000 48.43689  ? 90  LEU A CD1 1 
ATOM   594  C CD2 . LEU A 1 90  ? -23.07208 32.88027 7.06290   1.000 57.14720  ? 90  LEU A CD2 1 
ATOM   595  N N   . GLY A 1 91  ? -20.89766 37.49495 8.63764   1.000 62.39535  ? 91  GLY A N   1 
ATOM   596  C CA  . GLY A 1 91  ? -20.79316 38.76108 7.93841   1.000 60.55275  ? 91  GLY A CA  1 
ATOM   597  C C   . GLY A 1 91  ? -20.38343 38.66449 6.48934   1.000 61.41587  ? 91  GLY A C   1 
ATOM   598  O O   . GLY A 1 91  ? -20.71864 39.52539 5.66819   1.000 63.43905  ? 91  GLY A O   1 
ATOM   599  N N   . ARG A 1 92  ? -19.64107 37.61087 6.17900   1.000 57.33790  ? 92  ARG A N   1 
ATOM   600  C CA  . ARG A 1 92  ? -19.03844 37.38833 4.87732   1.000 62.02426  ? 92  ARG A CA  1 
ATOM   601  C C   . ARG A 1 92  ? -18.88940 35.89436 4.68452   1.000 71.55048  ? 92  ARG A C   1 
ATOM   602  O O   . ARG A 1 92  ? -18.39886 35.19759 5.57501   1.000 59.67095  ? 92  ARG A O   1 
ATOM   603  C CB  . ARG A 1 92  ? -17.64699 38.04411 4.74495   1.000 63.14446  ? 92  ARG A CB  1 
ATOM   604  C CG  . ARG A 1 92  ? -17.63873 39.54460 4.61602   1.000 61.88718  ? 92  ARG A CG  1 
ATOM   605  C CD  . ARG A 1 92  ? -17.34635 40.22852 5.91734   1.000 66.62420  ? 92  ARG A CD  1 
ATOM   606  N NE  . ARG A 1 92  ? -17.57777 41.65889 5.76640   1.000 76.59405  ? 92  ARG A NE  1 
ATOM   607  C CZ  . ARG A 1 92  ? -18.05934 42.44917 6.71523   1.000 90.02849  ? 92  ARG A CZ  1 
ATOM   608  N NH1 . ARG A 1 92  ? -18.27955 41.99776 7.94285   1.000 98.67557  ? 92  ARG A NH1 1 
ATOM   609  N NH2 . ARG A 1 92  ? -18.30433 43.72802 6.43140   1.000 90.37112  ? 92  ARG A NH2 1 
ATOM   610  N N   . LEU A 1 93  ? -19.30634 35.41508 3.51632   1.000 75.87705  ? 93  LEU A N   1 
ATOM   611  C CA  . LEU A 1 93  ? -19.04388 34.04017 3.10241   1.000 60.20133  ? 93  LEU A CA  1 
ATOM   612  C C   . LEU A 1 93  ? -18.71189 34.07159 1.62019   1.000 65.46776  ? 93  LEU A C   1 
ATOM   613  O O   . LEU A 1 93  ? -19.56171 34.46089 0.81809   1.000 78.66629  ? 93  LEU A O   1 
ATOM   614  C CB  . LEU A 1 93  ? -20.25209 33.16463 3.38726   1.000 75.99431  ? 93  LEU A CB  1 
ATOM   615  C CG  . LEU A 1 93  ? -20.13413 31.66241 3.17401   1.000 72.15823  ? 93  LEU A CG  1 
ATOM   616  C CD1 . LEU A 1 93  ? -19.11250 31.09815 4.12458   1.000 64.89271  ? 93  LEU A CD1 1 
ATOM   617  C CD2 . LEU A 1 93  ? -21.49128 31.03490 3.44628   1.000 87.28594  ? 93  LEU A CD2 1 
ATOM   618  N N   . ALA A 1 94  ? -17.48970 33.68458 1.26065   1.000 61.23513  ? 94  ALA A N   1 
ATOM   619  C CA  . ALA A 1 94  ? -17.07388 33.74266 -0.12970  1.000 62.16004  ? 94  ALA A CA  1 
ATOM   620  C C   . ALA A 1 94  ? -16.10475 32.60931 -0.43298  1.000 70.50925  ? 94  ALA A C   1 
ATOM   621  O O   . ALA A 1 94  ? -15.44045 32.07635 0.45884   1.000 64.71637  ? 94  ALA A O   1 
ATOM   622  C CB  . ALA A 1 94  ? -16.43256 35.09334 -0.46245  1.000 80.00666  ? 94  ALA A CB  1 
ATOM   623  N N   . VAL A 1 95  ? -16.01191 32.26571 -1.72021  1.000 78.61946  ? 95  VAL A N   1 
ATOM   624  C CA  . VAL A 1 95  ? -15.19544 31.14572 -2.18913  1.000 80.97884  ? 95  VAL A CA  1 
ATOM   625  C C   . VAL A 1 95  ? -14.51135 31.52122 -3.49751  1.000 89.89480  ? 95  VAL A C   1 
ATOM   626  O O   . VAL A 1 95  ? -15.11390 32.16207 -4.36639  1.000 103.57291 ? 95  VAL A O   1 
ATOM   627  C CB  . VAL A 1 95  ? -16.04543 29.86922 -2.36478  1.000 96.63755  ? 95  VAL A CB  1 
ATOM   628  C CG1 . VAL A 1 95  ? -15.49672 28.99458 -3.47845  1.000 88.46761  ? 95  VAL A CG1 1 
ATOM   629  C CG2 . VAL A 1 95  ? -16.07550 29.08330 -1.06808  1.000 95.38081  ? 95  VAL A CG2 1 
ATOM   630  N N   . ASP A 1 96  ? -13.26281 31.08532 -3.65004  1.000 85.12821  ? 96  ASP A N   1 
ATOM   631  C CA  . ASP A 1 96  ? -12.47513 31.47514 -4.80788  1.000 94.04483  ? 96  ASP A CA  1 
ATOM   632  C C   . ASP A 1 96  ? -13.07751 30.89972 -6.08915  1.000 90.98462  ? 96  ASP A C   1 
ATOM   633  O O   . ASP A 1 96  ? -13.62317 29.79354 -6.10989  1.000 101.08997 ? 96  ASP A O   1 
ATOM   634  C CB  . ASP A 1 96  ? -11.02770 31.00621 -4.64466  1.000 94.48724  ? 96  ASP A CB  1 
ATOM   635  C CG  . ASP A 1 96  ? -10.20897 31.18304 -5.91412  1.000 103.20458 ? 96  ASP A CG  1 
ATOM   636  O OD1 . ASP A 1 96  ? -10.47871 30.52624 -6.93573  1.000 114.53605 ? 96  ASP A OD1 1 
ATOM   637  O OD2 . ASP A 1 96  ? -9.27530  32.01075 -5.88942  1.000 102.05434 ? 96  ASP A OD2 1 
ATOM   638  N N   . VAL A 1 97  ? -12.95082 31.66313 -7.17863  1.000 94.07217  ? 97  VAL A N   1 
ATOM   639  C CA  . VAL A 1 97  ? -13.55826 31.29439 -8.45286  1.000 91.79839  ? 97  VAL A CA  1 
ATOM   640  C C   . VAL A 1 97  ? -12.92966 30.05964 -9.09339  1.000 92.50364  ? 97  VAL A C   1 
ATOM   641  O O   . VAL A 1 97  ? -13.50812 29.51278 -10.03907 1.000 90.77626  ? 97  VAL A O   1 
ATOM   642  C CB  . VAL A 1 97  ? -13.49181 32.49313 -9.42006  1.000 79.42057  ? 97  VAL A CB  1 
ATOM   643  C CG1 . VAL A 1 97  ? -12.17321 32.49278 -10.18831 1.000 80.06772  ? 97  VAL A CG1 1 
ATOM   644  C CG2 . VAL A 1 97  ? -14.69385 32.49743 -10.34966 1.000 78.33081  ? 97  VAL A CG2 1 
ATOM   645  N N   . CYS A 1 98  ? -11.77143 29.59560 -8.60464  1.000 85.63699  ? 98  CYS A N   1 
ATOM   646  C CA  . CYS A 1 98  ? -11.11862 28.39940 -9.13753  1.000 96.58576  ? 98  CYS A CA  1 
ATOM   647  C C   . CYS A 1 98  ? -11.58713 27.11898 -8.46120  1.000 112.51878 ? 98  CYS A C   1 
ATOM   648  O O   . CYS A 1 98  ? -11.04216 26.04395 -8.75355  1.000 91.99289  ? 98  CYS A O   1 
ATOM   649  C CB  . CYS A 1 98  ? -9.59233  28.49775 -9.00596  1.000 105.04689 ? 98  CYS A CB  1 
ATOM   650  S SG  . CYS A 1 98  ? -8.90328  27.91658 -7.41129  1.000 95.31031  ? 98  CYS A SG  1 
ATOM   651  N N   . THR A 1 99  ? -12.54291 27.22569 -7.53638  1.000 130.53756 ? 99  THR A N   1 
ATOM   652  C CA  . THR A 1 99  ? -13.30809 26.10332 -6.99578  1.000 121.13158 ? 99  THR A CA  1 
ATOM   653  C C   . THR A 1 99  ? -14.77850 26.41133 -7.23726  1.000 110.42117 ? 99  THR A C   1 
ATOM   654  O O   . THR A 1 99  ? -15.32089 27.35820 -6.65441  1.000 112.13556 ? 99  THR A O   1 
ATOM   655  C CB  . THR A 1 99  ? -13.04592 25.89455 -5.50024  1.000 113.94050 ? 99  THR A CB  1 
ATOM   656  O OG1 . THR A 1 99  ? -14.01773 26.62365 -4.74581  1.000 105.97119 ? 99  THR A OG1 1 
ATOM   657  C CG2 . THR A 1 99  ? -11.65112 26.36667 -5.10935  1.000 96.69293  ? 99  THR A CG2 1 
ATOM   658  N N   . ARG A 1 100 ? -15.41498 25.63778 -8.11018  1.000 93.39639  ? 100 ARG A N   1 
ATOM   659  C CA  . ARG A 1 100 ? -16.74774 26.01784 -8.55462  1.000 109.18645 ? 100 ARG A CA  1 
ATOM   660  C C   . ARG A 1 100 ? -17.78836 25.00178 -8.11143  1.000 104.27476 ? 100 ARG A C   1 
ATOM   661  O O   . ARG A 1 100 ? -18.44716 25.17176 -7.07544  1.000 101.90460 ? 100 ARG A O   1 
ATOM   662  C CB  . ARG A 1 100 ? -16.76378 26.17606 -10.07696 1.000 103.75484 ? 100 ARG A CB  1 
ATOM   663  N N   . GLY A 1 101 ? -17.94866 23.95522 -8.91938  1.000 109.19261 ? 101 GLY A N   1 
ATOM   664  C CA  . GLY A 1 101 ? -18.81425 22.84080 -8.60618  1.000 104.75107 ? 101 GLY A CA  1 
ATOM   665  C C   . GLY A 1 101 ? -18.31107 21.96307 -7.48895  1.000 109.54871 ? 101 GLY A C   1 
ATOM   666  O O   . GLY A 1 101 ? -19.02672 21.04232 -7.07951  1.000 119.67819 ? 101 GLY A O   1 
ATOM   667  N N   . HIS A 1 102 ? -17.09767 22.21475 -6.99206  1.000 112.58949 ? 102 HIS A N   1 
ATOM   668  C CA  . HIS A 1 102 ? -16.65994 21.54199 -5.77629  1.000 102.92101 ? 102 HIS A CA  1 
ATOM   669  C C   . HIS A 1 102 ? -17.59062 21.84817 -4.60534  1.000 113.91640 ? 102 HIS A C   1 
ATOM   670  O O   . HIS A 1 102 ? -17.67906 21.03936 -3.67079  1.000 106.69961 ? 102 HIS A O   1 
ATOM   671  C CB  . HIS A 1 102 ? -15.21343 21.93098 -5.44963  1.000 91.55908  ? 102 HIS A CB  1 
ATOM   672  C CG  . HIS A 1 102 ? -14.20911 21.40604 -6.43158  1.000 97.88066  ? 102 HIS A CG  1 
ATOM   673  N ND1 . HIS A 1 102 ? -14.25689 21.69431 -7.77959  1.000 100.62530 ? 102 HIS A ND1 1 
ATOM   674  C CD2 . HIS A 1 102 ? -13.14190 20.58799 -6.26131  1.000 98.97933  ? 102 HIS A CD2 1 
ATOM   675  C CE1 . HIS A 1 102 ? -13.25391 21.09059 -8.39472  1.000 104.13063 ? 102 HIS A CE1 1 
ATOM   676  N NE2 . HIS A 1 102 ? -12.56214 20.41276 -7.49548  1.000 109.04642 ? 102 HIS A NE2 1 
ATOM   677  N N   . GLY A 1 103 ? -18.31140 22.98006 -4.65781  1.000 114.13229 ? 103 GLY A N   1 
ATOM   678  C CA  . GLY A 1 103 ? -19.28415 23.34116 -3.64286  1.000 103.64185 ? 103 GLY A CA  1 
ATOM   679  C C   . GLY A 1 103 ? -18.69397 23.54106 -2.26119  1.000 109.85864 ? 103 GLY A C   1 
ATOM   680  O O   . GLY A 1 103 ? -19.13548 22.91537 -1.28753  1.000 87.58194  ? 103 GLY A O   1 
ATOM   681  N N   . PHE A 1 104 ? -17.68348 24.40780 -2.16268  1.000 104.03037 ? 104 PHE A N   1 
ATOM   682  C CA  . PHE A 1 104 ? -17.06236 24.66815 -0.87322  1.000 80.86057  ? 104 PHE A CA  1 
ATOM   683  C C   . PHE A 1 104 ? -17.81694 25.70323 -0.06203  1.000 75.41058  ? 104 PHE A C   1 
ATOM   684  O O   . PHE A 1 104 ? -17.47265 25.91758 1.10533   1.000 79.65799  ? 104 PHE A O   1 
ATOM   685  C CB  . PHE A 1 104 ? -15.61662 25.11512 -1.07321  1.000 98.32401  ? 104 PHE A CB  1 
ATOM   686  C CG  . PHE A 1 104 ? -14.70241 24.01518 -1.51560  1.000 91.24001  ? 104 PHE A CG  1 
ATOM   687  C CD1 . PHE A 1 104 ? -15.04787 22.68729 -1.32053  1.000 84.85977  ? 104 PHE A CD1 1 
ATOM   688  C CD2 . PHE A 1 104 ? -13.52162 24.31315 -2.17826  1.000 87.22246  ? 104 PHE A CD2 1 
ATOM   689  C CE1 . PHE A 1 104 ? -14.21500 21.67632 -1.74074  1.000 87.98517  ? 104 PHE A CE1 1 
ATOM   690  C CE2 . PHE A 1 104 ? -12.68466 23.31181 -2.61060  1.000 88.42381  ? 104 PHE A CE2 1 
ATOM   691  C CZ  . PHE A 1 104 ? -13.02984 21.98842 -2.39311  1.000 94.35973  ? 104 PHE A CZ  1 
ATOM   692  N N   . GLY A 1 105 ? -18.83112 26.34494 -0.64662  1.000 77.49433  ? 105 GLY A N   1 
ATOM   693  C CA  . GLY A 1 105 ? -19.66511 27.25371 0.13288   1.000 92.02013  ? 105 GLY A CA  1 
ATOM   694  C C   . GLY A 1 105 ? -20.44552 26.52953 1.21450   1.000 78.77299  ? 105 GLY A C   1 
ATOM   695  O O   . GLY A 1 105 ? -20.38084 26.89116 2.39330   1.000 72.68246  ? 105 GLY A O   1 
ATOM   696  N N   . LYS A 1 106 ? -21.18338 25.47904 0.82005   1.000 89.51324  ? 106 LYS A N   1 
ATOM   697  C CA  . LYS A 1 106 ? -21.91922 24.64783 1.77078   1.000 71.22596  ? 106 LYS A CA  1 
ATOM   698  C C   . LYS A 1 106 ? -20.99309 24.05953 2.82429   1.000 76.15895  ? 106 LYS A C   1 
ATOM   699  O O   . LYS A 1 106 ? -21.38587 23.91201 3.99047   1.000 83.10475  ? 106 LYS A O   1 
ATOM   700  C CB  . LYS A 1 106 ? -22.66314 23.53025 1.02301   1.000 68.06156  ? 106 LYS A CB  1 
ATOM   701  N N   . TRP A 1 107 ? -19.76181 23.72948 2.43346   1.000 70.67567  ? 107 TRP A N   1 
ATOM   702  C CA  . TRP A 1 107 ? -18.75968 23.27787 3.39205   1.000 65.01405  ? 107 TRP A CA  1 
ATOM   703  C C   . TRP A 1 107 ? -18.42465 24.35700 4.40662   1.000 69.38337  ? 107 TRP A C   1 
ATOM   704  O O   . TRP A 1 107 ? -18.18656 24.05408 5.58453   1.000 68.98480  ? 107 TRP A O   1 
ATOM   705  C CB  . TRP A 1 107 ? -17.48678 22.85671 2.66223   1.000 77.25932  ? 107 TRP A CB  1 
ATOM   706  C CG  . TRP A 1 107 ? -17.56283 21.53084 2.04794   1.000 76.58614  ? 107 TRP A CG  1 
ATOM   707  C CD1 . TRP A 1 107 ? -18.68456 20.90274 1.59466   1.000 92.53709  ? 107 TRP A CD1 1 
ATOM   708  C CD2 . TRP A 1 107 ? -16.47408 20.63925 1.80857   1.000 85.73487  ? 107 TRP A CD2 1 
ATOM   709  N NE1 . TRP A 1 107 ? -18.36212 19.66781 1.09319   1.000 88.09101  ? 107 TRP A NE1 1 
ATOM   710  C CE2 . TRP A 1 107 ? -17.00894 19.48259 1.20817   1.000 93.10643  ? 107 TRP A CE2 1 
ATOM   711  C CE3 . TRP A 1 107 ? -15.09628 20.70182 2.04608   1.000 94.51325  ? 107 TRP A CE3 1 
ATOM   712  C CZ2 . TRP A 1 107 ? -16.21344 18.39690 0.83304   1.000 82.50797  ? 107 TRP A CZ2 1 
ATOM   713  C CZ3 . TRP A 1 107 ? -14.30701 19.61847 1.67880   1.000 89.43037  ? 107 TRP A CZ3 1 
ATOM   714  C CH2 . TRP A 1 107 ? -14.86958 18.48511 1.07780   1.000 83.07980  ? 107 TRP A CH2 1 
ATOM   715  N N   . LEU A 1 108 ? -18.35267 25.62088 3.96451   1.000 67.86369  ? 108 LEU A N   1 
ATOM   716  C CA  . LEU A 1 108 ? -18.01899 26.68865 4.90379   1.000 69.21320  ? 108 LEU A CA  1 
ATOM   717  C C   . LEU A 1 108 ? -19.20398 27.01464 5.79688   1.000 64.74907  ? 108 LEU A C   1 
ATOM   718  O O   . LEU A 1 108 ? -19.02751 27.28091 6.99222   1.000 72.07291  ? 108 LEU A O   1 
ATOM   719  C CB  . LEU A 1 108 ? -17.54708 27.95929 4.18816   1.000 62.49478  ? 108 LEU A CB  1 
ATOM   720  C CG  . LEU A 1 108 ? -16.13557 28.13910 3.62983   1.000 64.05164  ? 108 LEU A CG  1 
ATOM   721  C CD1 . LEU A 1 108 ? -16.15485 29.33098 2.69162   1.000 62.04191  ? 108 LEU A CD1 1 
ATOM   722  C CD2 . LEU A 1 108 ? -15.07491 28.31410 4.71172   1.000 54.73037  ? 108 LEU A CD2 1 
ATOM   723  N N   . LEU A 1 109 ? -20.41963 26.99223 5.24401   1.000 58.34500  ? 109 LEU A N   1 
ATOM   724  C CA  . LEU A 1 109 ? -21.58834 27.30694 6.05728   1.000 56.18894  ? 109 LEU A CA  1 
ATOM   725  C C   . LEU A 1 109 ? -21.86650 26.20989 7.07499   1.000 56.03142  ? 109 LEU A C   1 
ATOM   726  O O   . LEU A 1 109 ? -22.35341 26.49114 8.18071   1.000 50.42058  ? 109 LEU A O   1 
ATOM   727  C CB  . LEU A 1 109 ? -22.79643 27.52610 5.16829   1.000 53.50885  ? 109 LEU A CB  1 
ATOM   728  C CG  . LEU A 1 109 ? -24.04862 27.97070 5.89364   1.000 53.00662  ? 109 LEU A CG  1 
ATOM   729  C CD1 . LEU A 1 109 ? -23.82253 29.18070 6.78789   1.000 42.95109  ? 109 LEU A CD1 1 
ATOM   730  C CD2 . LEU A 1 109 ? -25.14468 28.20095 4.87056   1.000 47.54078  ? 109 LEU A CD2 1 
ATOM   731  N N   . SER A 1 110 ? -21.55993 24.95582 6.73052   1.000 55.75979  ? 110 SER A N   1 
ATOM   732  C CA  . SER A 1 110 ? -21.59601 23.90485 7.74062   1.000 59.06698  ? 110 SER A CA  1 
ATOM   733  C C   . SER A 1 110 ? -20.66696 24.25913 8.89325   1.000 65.32567  ? 110 SER A C   1 
ATOM   734  O O   . SER A 1 110 ? -21.10513 24.38606 10.04341  1.000 63.92450  ? 110 SER A O   1 
ATOM   735  C CB  . SER A 1 110 ? -21.20898 22.55530 7.13117   1.000 54.91059  ? 110 SER A CB  1 
ATOM   736  O OG  . SER A 1 110 ? -21.82581 21.47585 7.82275   1.000 73.46476  ? 110 SER A OG  1 
ATOM   737  N N   . ASP A 1 111 ? -19.38763 24.48042 8.58833   1.000 54.11816  ? 111 ASP A N   1 
ATOM   738  C CA  . ASP A 1 111 ? -18.41497 24.77102 9.63031   1.000 55.22859  ? 111 ASP A CA  1 
ATOM   739  C C   . ASP A 1 111 ? -18.86477 25.93984 10.49379  1.000 50.51565  ? 111 ASP A C   1 
ATOM   740  O O   . ASP A 1 111 ? -18.85802 25.85079 11.72743  1.000 52.80844  ? 111 ASP A O   1 
ATOM   741  C CB  . ASP A 1 111 ? -17.05291 25.05897 8.98911   1.000 65.20081  ? 111 ASP A CB  1 
ATOM   742  C CG  . ASP A 1 111 ? -15.99479 25.37226 10.00838  1.000 66.61449  ? 111 ASP A CG  1 
ATOM   743  O OD1 . ASP A 1 111 ? -15.58372 24.42870 10.72156  1.000 54.21240  ? 111 ASP A OD1 1 
ATOM   744  O OD2 . ASP A 1 111 ? -15.61288 26.56934 10.11085  1.000 57.02556  ? 111 ASP A OD2 1 
ATOM   745  N N   . ALA A 1 112 ? -19.29956 27.02603 9.85895   1.000 50.43970  ? 112 ALA A N   1 
ATOM   746  C CA  . ALA A 1 112 ? -19.78557 28.19643 10.58680  1.000 53.99136  ? 112 ALA A CA  1 
ATOM   747  C C   . ALA A 1 112 ? -20.94594 27.85266 11.51566  1.000 53.41870  ? 112 ALA A C   1 
ATOM   748  O O   . ALA A 1 112 ? -20.93216 28.22010 12.69844  1.000 54.73592  ? 112 ALA A O   1 
ATOM   749  C CB  . ALA A 1 112 ? -20.20095 29.27767 9.59389   1.000 49.31171  ? 112 ALA A CB  1 
ATOM   750  N N   . ILE A 1 113 ? -21.98219 27.18026 10.99913  1.000 50.66940  ? 113 ILE A N   1 
ATOM   751  C CA  . ILE A 1 113 ? -23.13781 26.90995 11.84982  1.000 43.03246  ? 113 ILE A CA  1 
ATOM   752  C C   . ILE A 1 113 ? -22.73025 26.01537 13.00410  1.000 46.12362  ? 113 ILE A C   1 
ATOM   753  O O   . ILE A 1 113 ? -22.93432 26.36233 14.17071  1.000 60.42490  ? 113 ILE A O   1 
ATOM   754  C CB  . ILE A 1 113 ? -24.30840 26.31201 11.05146  1.000 58.46477  ? 113 ILE A CB  1 
ATOM   755  C CG1 . ILE A 1 113 ? -25.00304 27.40168 10.22292  1.000 46.75883  ? 113 ILE A CG1 1 
ATOM   756  C CG2 . ILE A 1 113 ? -25.30667 25.62952 12.00695  1.000 50.58672  ? 113 ILE A CG2 1 
ATOM   757  C CD1 . ILE A 1 113 ? -25.41900 28.64275 10.99426  1.000 40.98507  ? 113 ILE A CD1 1 
ATOM   758  N N   . HIS A 1 114 ? -22.11559 24.86906 12.70697  1.000 46.43868  ? 114 HIS A N   1 
ATOM   759  C CA  . HIS A 1 114 ? -21.56144 24.03921 13.77662  1.000 46.09457  ? 114 HIS A CA  1 
ATOM   760  C C   . HIS A 1 114 ? -20.77472 24.87213 14.77228  1.000 55.86063  ? 114 HIS A C   1 
ATOM   761  O O   . HIS A 1 114 ? -20.98648 24.76030 15.98002  1.000 54.64138  ? 114 HIS A O   1 
ATOM   762  C CB  . HIS A 1 114 ? -20.70313 22.92037 13.19356  1.000 49.69351  ? 114 HIS A CB  1 
ATOM   763  C CG  . HIS A 1 114 ? -21.53575 21.88438 12.53052  1.000 73.60104  ? 114 HIS A CG  1 
ATOM   764  N ND1 . HIS A 1 114 ? -22.20856 22.12908 11.35050  1.000 81.99416  ? 114 HIS A ND1 1 
ATOM   765  C CD2 . HIS A 1 114 ? -21.96168 20.67408 12.96533  1.000 73.97246  ? 114 HIS A CD2 1 
ATOM   766  C CE1 . HIS A 1 114 ? -22.95105 21.07820 11.04494  1.000 88.97451  ? 114 HIS A CE1 1 
ATOM   767  N NE2 . HIS A 1 114 ? -22.82277 20.18358 12.01156  1.000 76.48982  ? 114 HIS A NE2 1 
ATOM   768  N N   . ARG A 1 115 ? -19.91217 25.76379 14.27679  1.000 61.57647  ? 115 ARG A N   1 
ATOM   769  C CA  . ARG A 1 115 ? -19.12997 26.62683 15.15392  1.000 52.91611  ? 115 ARG A CA  1 
ATOM   770  C C   . ARG A 1 115 ? -20.03903 27.38555 16.10846  1.000 51.57879  ? 115 ARG A C   1 
ATOM   771  O O   . ARG A 1 115 ? -19.87955 27.31168 17.33230  1.000 65.41777  ? 115 ARG A O   1 
ATOM   772  C CB  . ARG A 1 115 ? -18.27500 27.57187 14.31711  1.000 46.48333  ? 115 ARG A CB  1 
ATOM   773  C CG  . ARG A 1 115 ? -17.24397 28.39611 15.09635  1.000 60.13571  ? 115 ARG A CG  1 
ATOM   774  C CD  . ARG A 1 115 ? -16.12553 28.88181 14.15379  1.000 51.71155  ? 115 ARG A CD  1 
ATOM   775  N NE  . ARG A 1 115 ? -14.90743 28.12599 14.39771  1.000 49.73674  ? 115 ARG A NE  1 
ATOM   776  C CZ  . ARG A 1 115 ? -14.39795 27.23667 13.55434  1.000 63.13951  ? 115 ARG A CZ  1 
ATOM   777  N NH1 . ARG A 1 115 ? -14.95544 27.00271 12.37370  1.000 53.32340  ? 115 ARG A NH1 1 
ATOM   778  N NH2 . ARG A 1 115 ? -13.32093 26.53677 13.91993  1.000 69.72766  ? 115 ARG A NH2 1 
ATOM   779  N N   . VAL A 1 116 ? -21.04037 28.08056 15.57224  1.000 60.96115  ? 116 VAL A N   1 
ATOM   780  C CA  . VAL A 1 116 ? -21.90745 28.90106 16.42343  1.000 50.14682  ? 116 VAL A CA  1 
ATOM   781  C C   . VAL A 1 116 ? -22.70341 28.03793 17.37954  1.000 46.44117  ? 116 VAL A C   1 
ATOM   782  O O   . VAL A 1 116 ? -23.10447 28.49477 18.45662  1.000 48.26967  ? 116 VAL A O   1 
ATOM   783  C CB  . VAL A 1 116 ? -22.82025 29.76542 15.54268  1.000 58.49162  ? 116 VAL A CB  1 
ATOM   784  C CG1 . VAL A 1 116 ? -23.68984 30.68804 16.40084  1.000 53.57219  ? 116 VAL A CG1 1 
ATOM   785  C CG2 . VAL A 1 116 ? -21.95121 30.55767 14.58571  1.000 48.69900  ? 116 VAL A CG2 1 
ATOM   786  N N   . VAL A 1 117 ? -22.93957 26.77586 17.01958  1.000 58.78719  ? 117 VAL A N   1 
ATOM   787  C CA  . VAL A 1 117 ? -23.71041 25.93222 17.92499  1.000 64.46850  ? 117 VAL A CA  1 
ATOM   788  C C   . VAL A 1 117 ? -22.86137 25.55395 19.13340  1.000 55.82778  ? 117 VAL A C   1 
ATOM   789  O O   . VAL A 1 117 ? -23.32211 25.61978 20.28024  1.000 62.47789  ? 117 VAL A O   1 
ATOM   790  C CB  . VAL A 1 117 ? -24.26694 24.71587 17.16837  1.000 46.66585  ? 117 VAL A CB  1 
ATOM   791  C CG1 . VAL A 1 117 ? -24.82476 23.71012 18.11672  1.000 60.05472  ? 117 VAL A CG1 1 
ATOM   792  C CG2 . VAL A 1 117 ? -25.35384 25.18816 16.23451  1.000 44.69409  ? 117 VAL A CG2 1 
ATOM   793  N N   . ASN A 1 118 ? -21.59512 25.21199 18.90241  1.000 57.64998  ? 118 ASN A N   1 
ATOM   794  C CA  . ASN A 1 118 ? -20.65030 25.04824 20.00547  1.000 58.14314  ? 118 ASN A CA  1 
ATOM   795  C C   . ASN A 1 118 ? -20.54085 26.32180 20.81242  1.000 57.14307  ? 118 ASN A C   1 
ATOM   796  O O   . ASN A 1 118 ? -20.51696 26.29556 22.05181  1.000 62.26087  ? 118 ASN A O   1 
ATOM   797  C CB  . ASN A 1 118 ? -19.27938 24.68036 19.45771  1.000 53.73887  ? 118 ASN A CB  1 
ATOM   798  C CG  . ASN A 1 118 ? -19.27914 23.33189 18.83582  1.000 61.06547  ? 118 ASN A CG  1 
ATOM   799  O OD1 . ASN A 1 118 ? -20.24091 22.57770 18.98373  1.000 77.39839  ? 118 ASN A OD1 1 
ATOM   800  N ND2 . ASN A 1 118 ? -18.20381 22.99446 18.13268  1.000 81.15559  ? 118 ASN A ND2 1 
ATOM   801  N N   . LEU A 1 119 ? -20.40398 27.44215 20.11372  1.000 58.19548  ? 119 LEU A N   1 
ATOM   802  C CA  . LEU A 1 119 ? -20.44819 28.73510 20.76604  1.000 48.38897  ? 119 LEU A CA  1 
ATOM   803  C C   . LEU A 1 119 ? -21.58847 28.79395 21.76033  1.000 48.79871  ? 119 LEU A C   1 
ATOM   804  O O   . LEU A 1 119 ? -21.37233 29.02995 22.94766  1.000 56.53058  ? 119 LEU A O   1 
ATOM   805  C CB  . LEU A 1 119 ? -20.61431 29.80035 19.69920  1.000 57.39193  ? 119 LEU A CB  1 
ATOM   806  C CG  . LEU A 1 119 ? -20.69116 31.25695 20.06734  1.000 57.32711  ? 119 LEU A CG  1 
ATOM   807  C CD1 . LEU A 1 119 ? -19.46644 31.55736 20.82458  1.000 66.36552  ? 119 LEU A CD1 1 
ATOM   808  C CD2 . LEU A 1 119 ? -20.69448 32.01250 18.79075  1.000 72.88699  ? 119 LEU A CD2 1 
ATOM   809  N N   . ALA A 1 120 ? -22.80896 28.51071 21.30132  1.000 57.50455  ? 120 ALA A N   1 
ATOM   810  C CA  . ALA A 1 120 ? -23.99541 28.60199 22.14996  1.000 57.03318  ? 120 ALA A CA  1 
ATOM   811  C C   . ALA A 1 120 ? -23.97345 27.63206 23.32786  1.000 54.81895  ? 120 ALA A C   1 
ATOM   812  O O   . ALA A 1 120 ? -24.82814 27.73589 24.21013  1.000 64.00752  ? 120 ALA A O   1 
ATOM   813  C CB  . ALA A 1 120 ? -25.25326 28.36934 21.32326  1.000 55.05234  ? 120 ALA A CB  1 
ATOM   814  N N   . ASP A 1 121 ? -23.03132 26.70110 23.37754  1.000 58.96183  ? 121 ASP A N   1 
ATOM   815  C CA  . ASP A 1 121 ? -22.86375 25.88397 24.56380  1.000 57.46461  ? 121 ASP A CA  1 
ATOM   816  C C   . ASP A 1 121 ? -21.85938 26.47208 25.51145  1.000 59.17771  ? 121 ASP A C   1 
ATOM   817  O O   . ASP A 1 121 ? -21.38477 25.78367 26.42288  1.000 78.46971  ? 121 ASP A O   1 
ATOM   818  C CB  . ASP A 1 121 ? -22.48196 24.46952 24.17070  1.000 60.11887  ? 121 ASP A CB  1 
ATOM   819  C CG  . ASP A 1 121 ? -23.69711 23.66363 23.85572  1.000 97.41578  ? 121 ASP A CG  1 
ATOM   820  O OD1 . ASP A 1 121 ? -24.06605 22.79571 24.68282  1.000 107.74183 ? 121 ASP A OD1 1 
ATOM   821  O OD2 . ASP A 1 121 ? -24.34521 23.98241 22.82534  1.000 103.80354 ? 121 ASP A OD2 1 
ATOM   822  N N   . GLN A 1 122 ? -21.51167 27.71530 25.29919  1.000 54.60158  ? 122 GLN A N   1 
ATOM   823  C CA  . GLN A 1 122 ? -20.67867 28.47096 26.20261  1.000 51.19269  ? 122 GLN A CA  1 
ATOM   824  C C   . GLN A 1 122 ? -21.37522 29.71789 26.68367  1.000 52.85634  ? 122 GLN A C   1 
ATOM   825  O O   . GLN A 1 122 ? -21.12900 30.15429 27.80254  1.000 66.92334  ? 122 GLN A O   1 
ATOM   826  C CB  . GLN A 1 122 ? -19.36994 28.85065 25.51668  1.000 51.97552  ? 122 GLN A CB  1 
ATOM   827  C CG  . GLN A 1 122 ? -18.73358 27.70166 24.76485  1.000 51.40000  ? 122 GLN A CG  1 
ATOM   828  C CD  . GLN A 1 122 ? -18.14746 26.70195 25.70927  1.000 54.03713  ? 122 GLN A CD  1 
ATOM   829  O OE1 . GLN A 1 122 ? -17.78299 27.04657 26.83035  1.000 64.73492  ? 122 GLN A OE1 1 
ATOM   830  N NE2 . GLN A 1 122 ? -18.02379 25.45509 25.27053  1.000 84.49869  ? 122 GLN A NE2 1 
ATOM   831  N N   . VAL A 1 123 ? -22.31195 30.24791 25.89805  1.000 71.47659  ? 123 VAL A N   1 
ATOM   832  C CA  . VAL A 1 123 ? -22.90908 31.55853 26.12907  1.000 72.89043  ? 123 VAL A CA  1 
ATOM   833  C C   . VAL A 1 123 ? -24.26861 31.51889 25.44256  1.000 52.86432  ? 123 VAL A C   1 
ATOM   834  O O   . VAL A 1 123 ? -24.49641 30.72606 24.53657  1.000 55.86686  ? 123 VAL A O   1 
ATOM   835  C CB  . VAL A 1 123 ? -21.96911 32.67158 25.55001  1.000 70.00696  ? 123 VAL A CB  1 
ATOM   836  C CG1 . VAL A 1 123 ? -22.43833 33.14746 24.17597  1.000 49.04852  ? 123 VAL A CG1 1 
ATOM   837  C CG2 . VAL A 1 123 ? -21.70206 33.80828 26.54608  1.000 56.62194  ? 123 VAL A CG2 1 
ATOM   838  N N   . GLY A 1 124 ? -25.18885 32.35406 25.88112  1.000 57.20528  ? 124 GLY A N   1 
ATOM   839  C CA  . GLY A 1 124 ? -26.52252 32.27860 25.28686  1.000 60.76594  ? 124 GLY A CA  1 
ATOM   840  C C   . GLY A 1 124 ? -26.60751 32.86687 23.88924  1.000 58.81890  ? 124 GLY A C   1 
ATOM   841  O O   . GLY A 1 124 ? -26.33422 34.06113 23.70806  1.000 57.87859  ? 124 GLY A O   1 
ATOM   842  N N   . ILE A 1 125 ? -26.96158 32.06158 22.88713  1.000 54.06540  ? 125 ILE A N   1 
ATOM   843  C CA  . ILE A 1 125 ? -27.05574 32.56255 21.51652  1.000 57.14279  ? 125 ILE A CA  1 
ATOM   844  C C   . ILE A 1 125 ? -28.34307 32.04743 20.89110  1.000 57.88408  ? 125 ILE A C   1 
ATOM   845  O O   . ILE A 1 125 ? -28.56226 30.83455 20.81945  1.000 58.98741  ? 125 ILE A O   1 
ATOM   846  C CB  . ILE A 1 125 ? -25.84538 32.16932 20.64717  1.000 54.70808  ? 125 ILE A CB  1 
ATOM   847  C CG1 . ILE A 1 125 ? -24.59417 32.80464 21.23319  1.000 54.63254  ? 125 ILE A CG1 1 
ATOM   848  C CG2 . ILE A 1 125 ? -26.00727 32.72791 19.21983  1.000 50.96347  ? 125 ILE A CG2 1 
ATOM   849  C CD1 . ILE A 1 125 ? -24.49397 34.27016 20.95435  1.000 65.21932  ? 125 ILE A CD1 1 
ATOM   850  N N   . LYS A 1 126 ? -29.17817 32.96866 20.40978  1.000 55.63187  ? 126 LYS A N   1 
ATOM   851  C CA  . LYS A 1 126 ? -30.54147 32.66153 20.01504  1.000 54.59110  ? 126 LYS A CA  1 
ATOM   852  C C   . LYS A 1 126 ? -30.72384 32.46862 18.51589  1.000 49.82167  ? 126 LYS A C   1 
ATOM   853  O O   . LYS A 1 126 ? -31.65649 31.76891 18.11110  1.000 54.46814  ? 126 LYS A O   1 
ATOM   854  C CB  . LYS A 1 126 ? -31.49255 33.75043 20.51160  1.000 56.01876  ? 126 LYS A CB  1 
ATOM   855  C CG  . LYS A 1 126 ? -32.02108 33.50561 21.92285  1.000 68.81480  ? 126 LYS A CG  1 
ATOM   856  C CD  . LYS A 1 126 ? -32.97496 34.64612 22.37320  1.000 95.43173  ? 126 LYS A CD  1 
ATOM   857  C CE  . LYS A 1 126 ? -34.33514 34.13796 22.91928  1.000 96.76974  ? 126 LYS A CE  1 
ATOM   858  N NZ  . LYS A 1 126 ? -35.28207 35.18290 23.44686  1.000 73.75700  ? 126 LYS A NZ  1 
ATOM   859  N N   . ALA A 1 127 ? -29.86138 33.04217 17.68894  1.000 51.23416  ? 127 ALA A N   1 
ATOM   860  C CA  . ALA A 1 127 ? -29.90258 32.82493 16.25368  1.000 45.39448  ? 127 ALA A CA  1 
ATOM   861  C C   . ALA A 1 127 ? -28.62443 33.36414 15.62230  1.000 45.74630  ? 127 ALA A C   1 
ATOM   862  O O   . ALA A 1 127 ? -27.89292 34.15056 16.22694  1.000 51.07684  ? 127 ALA A O   1 
ATOM   863  C CB  . ALA A 1 127 ? -31.11924 33.49726 15.62323  1.000 47.08719  ? 127 ALA A CB  1 
ATOM   864  N N   . VAL A 1 128 ? -28.37070 32.91310 14.39398  1.000 48.52916  ? 128 VAL A N   1 
ATOM   865  C CA  . VAL A 1 128 ? -27.41606 33.51686 13.47686  1.000 46.07871  ? 128 VAL A CA  1 
ATOM   866  C C   . VAL A 1 128 ? -28.17473 34.36734 12.46321  1.000 52.93681  ? 128 VAL A C   1 
ATOM   867  O O   . VAL A 1 128 ? -29.24616 33.96486 11.99977  1.000 59.93095  ? 128 VAL A O   1 
ATOM   868  C CB  . VAL A 1 128 ? -26.59343 32.43700 12.76501  1.000 37.62991  ? 128 VAL A CB  1 
ATOM   869  C CG1 . VAL A 1 128 ? -25.63319 33.06828 11.79571  1.000 39.89500  ? 128 VAL A CG1 1 
ATOM   870  C CG2 . VAL A 1 128 ? -25.87136 31.55017 13.78905  1.000 42.33096  ? 128 VAL A CG2 1 
ATOM   871  N N   . MET A 1 129 ? -27.61573 35.54454 12.11395  1.000 72.43417  ? 129 MET A N   1 
ATOM   872  C CA  . MET A 1 129 ? -28.16929 36.45624 11.11335  1.000 56.13028  ? 129 MET A CA  1 
ATOM   873  C C   . MET A 1 129 ? -27.24345 36.57873 9.91280   1.000 49.26118  ? 129 MET A C   1 
ATOM   874  O O   . MET A 1 129 ? -26.02567 36.41154 10.02639  1.000 62.71134  ? 129 MET A O   1 
ATOM   875  C CB  . MET A 1 129 ? -28.36901 37.84440 11.68345  1.000 54.08961  ? 129 MET A CB  1 
ATOM   876  C CG  . MET A 1 129 ? -28.72002 37.78997 13.11150  1.000 69.54969  ? 129 MET A CG  1 
ATOM   877  S SD  . MET A 1 129 ? -30.48909 37.81834 13.12980  1.000 89.86898  ? 129 MET A SD  1 
ATOM   878  C CE  . MET A 1 129 ? -30.75652 39.54192 13.52107  1.000 78.70660  ? 129 MET A CE  1 
ATOM   879  N N   . VAL A 1 130 ? -27.82752 36.89245 8.75657   1.000 50.76612  ? 130 VAL A N   1 
ATOM   880  C CA  . VAL A 1 130 ? -27.04094 37.16608 7.55833   1.000 54.56824  ? 130 VAL A CA  1 
ATOM   881  C C   . VAL A 1 130 ? -27.84779 38.05216 6.62695   1.000 60.47096  ? 130 VAL A C   1 
ATOM   882  O O   . VAL A 1 130 ? -29.07796 37.95472 6.55379   1.000 62.64527  ? 130 VAL A O   1 
ATOM   883  C CB  . VAL A 1 130 ? -26.59884 35.86391 6.84715   1.000 52.70150  ? 130 VAL A CB  1 
ATOM   884  C CG1 . VAL A 1 130 ? -27.76028 35.20811 6.18318   1.000 62.69371  ? 130 VAL A CG1 1 
ATOM   885  C CG2 . VAL A 1 130 ? -25.54819 36.17312 5.79318   1.000 63.57567  ? 130 VAL A CG2 1 
ATOM   886  N N   . HIS A 1 131 ? -27.14394 38.92094 5.90451   1.000 78.84581  ? 131 HIS A N   1 
ATOM   887  C CA  . HIS A 1 131 ? -27.73258 39.84241 4.94396   1.000 59.52269  ? 131 HIS A CA  1 
ATOM   888  C C   . HIS A 1 131 ? -27.41220 39.32404 3.55180   1.000 60.91709  ? 131 HIS A C   1 
ATOM   889  O O   . HIS A 1 131 ? -26.24404 39.12833 3.20733   1.000 60.97100  ? 131 HIS A O   1 
ATOM   890  C CB  . HIS A 1 131 ? -27.19876 41.25940 5.13470   1.000 61.32154  ? 131 HIS A CB  1 
ATOM   891  N N   . ALA A 1 132 ? -28.44391 39.06524 2.76189   1.000 88.01029  ? 132 ALA A N   1 
ATOM   892  C CA  . ALA A 1 132 ? -28.21527 38.51718 1.43288   1.000 95.39040  ? 132 ALA A CA  1 
ATOM   893  C C   . ALA A 1 132 ? -27.93963 39.66957 0.47193   1.000 88.57520  ? 132 ALA A C   1 
ATOM   894  O O   . ALA A 1 132 ? -28.76843 40.57828 0.32183   1.000 80.57366  ? 132 ALA A O   1 
ATOM   895  C CB  . ALA A 1 132 ? -29.40341 37.67422 0.97546   1.000 74.63255  ? 132 ALA A CB  1 
ATOM   896  N N   . ILE A 1 133 ? -26.75188 39.63840 -0.13282  1.000 74.27391  ? 133 ILE A N   1 
ATOM   897  C CA  . ILE A 1 133 ? -26.30053 40.58742 -1.14024  1.000 85.18498  ? 133 ILE A CA  1 
ATOM   898  C C   . ILE A 1 133 ? -27.27853 40.58480 -2.30259  1.000 94.02377  ? 133 ILE A C   1 
ATOM   899  O O   . ILE A 1 133 ? -28.18280 41.42726 -2.39198  1.000 91.52415  ? 133 ILE A O   1 
ATOM   900  C CB  . ILE A 1 133 ? -24.88090 40.22904 -1.62621  1.000 77.09521  ? 133 ILE A CB  1 
ATOM   901  N N   . ASP A 1 134 ? -27.07889 39.63604 -3.20327  1.000 97.51626  ? 134 ASP A N   1 
ATOM   902  C CA  . ASP A 1 134 ? -28.00479 39.31473 -4.27184  1.000 99.99004  ? 134 ASP A CA  1 
ATOM   903  C C   . ASP A 1 134 ? -28.98530 38.23901 -3.80569  1.000 102.96456 ? 134 ASP A C   1 
ATOM   904  O O   . ASP A 1 134 ? -28.88283 37.69640 -2.70230  1.000 107.93698 ? 134 ASP A O   1 
ATOM   905  C CB  . ASP A 1 134 ? -27.21480 38.85790 -5.50020  1.000 97.64107  ? 134 ASP A CB  1 
ATOM   906  C CG  . ASP A 1 134 ? -25.97920 38.05183 -5.12648  1.000 98.56276  ? 134 ASP A CG  1 
ATOM   907  O OD1 . ASP A 1 134 ? -24.85380 38.59452 -5.22130  1.000 106.25540 ? 134 ASP A OD1 1 
ATOM   908  O OD2 . ASP A 1 134 ? -26.13338 36.87952 -4.71613  1.000 98.26866  ? 134 ASP A OD2 1 
ATOM   909  N N   . ASP A 1 135 ? -29.95866 37.93838 -4.66147  1.000 104.97197 ? 135 ASP A N   1 
ATOM   910  C CA  . ASP A 1 135 ? -30.85836 36.83141 -4.36281  1.000 106.49180 ? 135 ASP A CA  1 
ATOM   911  C C   . ASP A 1 135 ? -30.12244 35.49244 -4.36276  1.000 98.01693  ? 135 ASP A C   1 
ATOM   912  O O   . ASP A 1 135 ? -30.55778 34.55100 -3.68653  1.000 98.68660  ? 135 ASP A O   1 
ATOM   913  C CB  . ASP A 1 135 ? -32.02721 36.82458 -5.35384  1.000 102.38574 ? 135 ASP A CB  1 
ATOM   914  C CG  . ASP A 1 135 ? -31.58295 37.08232 -6.78394  1.000 114.04974 ? 135 ASP A CG  1 
ATOM   915  O OD1 . ASP A 1 135 ? -30.51632 36.56349 -7.17993  1.000 122.38948 ? 135 ASP A OD1 1 
ATOM   916  O OD2 . ASP A 1 135 ? -32.29658 37.81570 -7.50707  1.000 107.46008 ? 135 ASP A OD2 1 
ATOM   917  N N   . ASP A 1 136 ? -29.00047 35.39022 -5.09197  1.000 101.38630 ? 136 ASP A N   1 
ATOM   918  C CA  . ASP A 1 136 ? -28.23166 34.13910 -5.11058  1.000 110.65838 ? 136 ASP A CA  1 
ATOM   919  C C   . ASP A 1 136 ? -27.63678 33.83348 -3.74334  1.000 102.38751 ? 136 ASP A C   1 
ATOM   920  O O   . ASP A 1 136 ? -27.51940 32.66561 -3.35161  1.000 92.85248  ? 136 ASP A O   1 
ATOM   921  C CB  . ASP A 1 136 ? -27.10340 34.19278 -6.14450  1.000 103.10052 ? 136 ASP A CB  1 
ATOM   922  C CG  . ASP A 1 136 ? -27.52437 34.83353 -7.44559  1.000 129.98914 ? 136 ASP A CG  1 
ATOM   923  O OD1 . ASP A 1 136 ? -27.51227 36.09487 -7.49901  1.000 130.05048 ? 136 ASP A OD1 1 
ATOM   924  O OD2 . ASP A 1 136 ? -27.83286 34.07439 -8.40463  1.000 120.68300 ? 136 ASP A OD2 1 
ATOM   925  N N   . ALA A 1 137 ? -27.19308 34.86947 -3.03120  1.000 99.87985  ? 137 ALA A N   1 
ATOM   926  C CA  . ALA A 1 137 ? -26.91674 34.71046 -1.61297  1.000 86.08882  ? 137 ALA A CA  1 
ATOM   927  C C   . ALA A 1 137 ? -28.15954 34.20277 -0.89718  1.000 93.75550  ? 137 ALA A C   1 
ATOM   928  O O   . ALA A 1 137 ? -28.14070 33.12823 -0.28256  1.000 85.23510  ? 137 ALA A O   1 
ATOM   929  C CB  . ALA A 1 137 ? -26.43076 36.03309 -1.01863  1.000 76.55324  ? 137 ALA A CB  1 
ATOM   930  N N   . ARG A 1 138 ? -29.26717 34.94333 -1.01888  1.000 88.27122  ? 138 ARG A N   1 
ATOM   931  C CA  . ARG A 1 138 ? -30.52567 34.55142 -0.38643  1.000 75.94546  ? 138 ARG A CA  1 
ATOM   932  C C   . ARG A 1 138 ? -30.93596 33.14005 -0.77185  1.000 75.72190  ? 138 ARG A C   1 
ATOM   933  O O   . ARG A 1 138 ? -31.40358 32.37354 0.07548   1.000 79.81578  ? 138 ARG A O   1 
ATOM   934  C CB  . ARG A 1 138 ? -31.63130 35.53924 -0.75449  1.000 74.41578  ? 138 ARG A CB  1 
ATOM   935  C CG  . ARG A 1 138 ? -33.02355 34.94850 -0.70579  1.000 81.07762  ? 138 ARG A CG  1 
ATOM   936  C CD  . ARG A 1 138 ? -34.05532 35.99989 -1.08503  1.000 88.97499  ? 138 ARG A CD  1 
ATOM   937  N NE  . ARG A 1 138 ? -34.27198 36.99435 -0.03832  1.000 80.51121  ? 138 ARG A NE  1 
ATOM   938  C CZ  . ARG A 1 138 ? -35.07212 36.83212 1.00899   1.000 86.92011  ? 138 ARG A CZ  1 
ATOM   939  N NH1 . ARG A 1 138 ? -35.81271 35.74359 1.15554   1.000 71.71556  ? 138 ARG A NH1 1 
ATOM   940  N NH2 . ARG A 1 138 ? -35.14319 37.79545 1.92483   1.000 98.12336  ? 138 ARG A NH2 1 
ATOM   941  N N   . ALA A 1 139 ? -30.76945 32.76883 -2.04048  1.000 79.16842  ? 139 ALA A N   1 
ATOM   942  C CA  . ALA A 1 139 ? -31.17335 31.42269 -2.43493  1.000 78.02404  ? 139 ALA A CA  1 
ATOM   943  C C   . ALA A 1 139 ? -30.26244 30.37619 -1.81309  1.000 63.57493  ? 139 ALA A C   1 
ATOM   944  O O   . ALA A 1 139 ? -30.73263 29.32395 -1.36881  1.000 73.49429  ? 139 ALA A O   1 
ATOM   945  C CB  . ALA A 1 139 ? -31.19451 31.28393 -3.95598  1.000 88.32098  ? 139 ALA A CB  1 
ATOM   946  N N   . PHE A 1 140 ? -28.95578 30.64590 -1.78437  1.000 84.71646  ? 140 PHE A N   1 
ATOM   947  C CA  . PHE A 1 140 ? -28.01035 29.77623 -1.08658  1.000 67.59477  ? 140 PHE A CA  1 
ATOM   948  C C   . PHE A 1 140 ? -28.37692 29.65914 0.38541   1.000 67.87341  ? 140 PHE A C   1 
ATOM   949  O O   . PHE A 1 140 ? -28.41629 28.55988 0.95123   1.000 58.62623  ? 140 PHE A O   1 
ATOM   950  C CB  . PHE A 1 140 ? -26.60449 30.34694 -1.26280  1.000 58.88538  ? 140 PHE A CB  1 
ATOM   951  C CG  . PHE A 1 140 ? -25.56494 29.76692 -0.34349  1.000 55.68407  ? 140 PHE A CG  1 
ATOM   952  C CD1 . PHE A 1 140 ? -24.84485 28.64170 -0.70870  1.000 55.36720  ? 140 PHE A CD1 1 
ATOM   953  C CD2 . PHE A 1 140 ? -25.28374 30.36829 0.87375   1.000 56.94297  ? 140 PHE A CD2 1 
ATOM   954  C CE1 . PHE A 1 140 ? -23.86888 28.11330 0.13149   1.000 55.19391  ? 140 PHE A CE1 1 
ATOM   955  C CE2 . PHE A 1 140 ? -24.31734 29.85326 1.71245   1.000 55.66030  ? 140 PHE A CE2 1 
ATOM   956  C CZ  . PHE A 1 140 ? -23.61125 28.72232 1.34500   1.000 64.01216  ? 140 PHE A CZ  1 
ATOM   957  N N   . TYR A 1 141 ? -28.67023 30.79698 1.01564   1.000 75.58835  ? 141 TYR A N   1 
ATOM   958  C CA  . TYR A 1 141 ? -28.93685 30.82816 2.44623   1.000 61.80623  ? 141 TYR A CA  1 
ATOM   959  C C   . TYR A 1 141 ? -30.33433 30.29728 2.76915   1.000 56.72478  ? 141 TYR A C   1 
ATOM   960  O O   . TYR A 1 141 ? -30.54141 29.71524 3.83490   1.000 61.13798  ? 141 TYR A O   1 
ATOM   961  C CB  . TYR A 1 141 ? -28.70611 32.25971 2.97709   1.000 61.67099  ? 141 TYR A CB  1 
ATOM   962  C CG  . TYR A 1 141 ? -27.21049 32.67321 3.07488   1.000 78.75180  ? 141 TYR A CG  1 
ATOM   963  C CD1 . TYR A 1 141 ? -26.31003 31.95317 3.85508   1.000 53.33097  ? 141 TYR A CD1 1 
ATOM   964  C CD2 . TYR A 1 141 ? -26.71563 33.80299 2.38905   1.000 75.01643  ? 141 TYR A CD2 1 
ATOM   965  C CE1 . TYR A 1 141 ? -24.96320 32.35022 3.94031   1.000 67.64755  ? 141 TYR A CE1 1 
ATOM   966  C CE2 . TYR A 1 141 ? -25.37207 34.19304 2.47730   1.000 57.48460  ? 141 TYR A CE2 1 
ATOM   967  C CZ  . TYR A 1 141 ? -24.50482 33.46682 3.25156   1.000 52.87465  ? 141 TYR A CZ  1 
ATOM   968  N N   . GLU A 1 142 ? -31.29314 30.42087 1.85490   1.000 73.99911  ? 142 GLU A N   1 
ATOM   969  C CA  . GLU A 1 142 ? -32.59772 29.81535 2.09952   1.000 63.31826  ? 142 GLU A CA  1 
ATOM   970  C C   . GLU A 1 142 ? -32.58676 28.30886 1.80270   1.000 63.56891  ? 142 GLU A C   1 
ATOM   971  O O   . GLU A 1 142 ? -33.32733 27.55556 2.44036   1.000 72.80062  ? 142 GLU A O   1 
ATOM   972  C CB  . GLU A 1 142 ? -33.66645 30.56019 1.29663   1.000 61.21919  ? 142 GLU A CB  1 
ATOM   973  C CG  . GLU A 1 142 ? -34.36440 31.68375 2.10189   1.000 77.91527  ? 142 GLU A CG  1 
ATOM   974  C CD  . GLU A 1 142 ? -35.37470 32.50428 1.28035   1.000 88.34096  ? 142 GLU A CD  1 
ATOM   975  O OE1 . GLU A 1 142 ? -35.29168 32.44618 0.02935   1.000 90.06819  ? 142 GLU A OE1 1 
ATOM   976  O OE2 . GLU A 1 142 ? -36.25749 33.17918 1.88185   1.000 82.20531  ? 142 GLU A OE2 1 
ATOM   977  N N   . ARG A 1 143 ? -31.72224 27.83509 0.89702   1.000 59.13662  ? 143 ARG A N   1 
ATOM   978  C CA  . ARG A 1 143 ? -31.57271 26.40292 0.65332   1.000 57.91291  ? 143 ARG A CA  1 
ATOM   979  C C   . ARG A 1 143 ? -30.98556 25.64663 1.84232   1.000 59.27313  ? 143 ARG A C   1 
ATOM   980  O O   . ARG A 1 143 ? -30.86714 24.41372 1.77607   1.000 67.54221  ? 143 ARG A O   1 
ATOM   981  C CB  . ARG A 1 143 ? -30.69031 26.15493 -0.58830  1.000 63.71147  ? 143 ARG A CB  1 
ATOM   982  C CG  . ARG A 1 143 ? -31.06705 24.90235 -1.44483  1.000 87.07133  ? 143 ARG A CG  1 
ATOM   983  C CD  . ARG A 1 143 ? -32.49385 25.00116 -2.06473  1.000 83.00765  ? 143 ARG A CD  1 
ATOM   984  N NE  . ARG A 1 143 ? -32.52456 24.59965 -3.46906  1.000 95.71082  ? 143 ARG A NE  1 
ATOM   985  C CZ  . ARG A 1 143 ? -33.61730 24.27967 -4.15408  1.000 109.65269 ? 143 ARG A CZ  1 
ATOM   986  N NH1 . ARG A 1 143 ? -34.81969 24.29739 -3.59539  1.000 110.25326 ? 143 ARG A NH1 1 
ATOM   987  N NH2 . ARG A 1 143 ? -33.50319 23.95574 -5.44202  1.000 104.02331 ? 143 ARG A NH2 1 
ATOM   988  N N   . PHE A 1 144 ? -30.61913 26.33510 2.92792   1.000 73.54934  ? 144 PHE A N   1 
ATOM   989  C CA  . PHE A 1 144 ? -29.82736 25.73810 4.00559   1.000 66.66475  ? 144 PHE A CA  1 
ATOM   990  C C   . PHE A 1 144 ? -30.30900 26.18837 5.38432   1.000 53.88946  ? 144 PHE A C   1 
ATOM   991  O O   . PHE A 1 144 ? -29.59440 26.04216 6.37459   1.000 46.77425  ? 144 PHE A O   1 
ATOM   992  C CB  . PHE A 1 144 ? -28.34863 26.04472 3.80012   1.000 49.12403  ? 144 PHE A CB  1 
ATOM   993  C CG  . PHE A 1 144 ? -27.69677 25.22556 2.71333   1.000 55.77042  ? 144 PHE A CG  1 
ATOM   994  C CD1 . PHE A 1 144 ? -27.49733 23.86675 2.87267   1.000 62.42235  ? 144 PHE A CD1 1 
ATOM   995  C CD2 . PHE A 1 144 ? -27.28410 25.81938 1.54013   1.000 50.38077  ? 144 PHE A CD2 1 
ATOM   996  C CE1 . PHE A 1 144 ? -26.87944 23.11564 1.86982   1.000 63.68676  ? 144 PHE A CE1 1 
ATOM   997  C CE2 . PHE A 1 144 ? -26.67063 25.08167 0.54127   1.000 51.35009  ? 144 PHE A CE2 1 
ATOM   998  C CZ  . PHE A 1 144 ? -26.47137 23.72987 0.70459   1.000 63.79997  ? 144 PHE A CZ  1 
ATOM   999  N N   . GLY A 1 145 ? -31.53963 26.69843 5.45469   1.000 51.89286  ? 145 GLY A N   1 
ATOM   1000 C CA  . GLY A 1 145 ? -32.26745 26.79585 6.69260   1.000 60.25871  ? 145 GLY A CA  1 
ATOM   1001 C C   . GLY A 1 145 ? -32.69136 28.19861 7.03774   1.000 57.19396  ? 145 GLY A C   1 
ATOM   1002 O O   . GLY A 1 145 ? -33.70158 28.38428 7.72878   1.000 61.14597  ? 145 GLY A O   1 
ATOM   1003 N N   . PHE A 1 146 ? -31.95148 29.17907 6.55787   1.000 63.81070  ? 146 PHE A N   1 
ATOM   1004 C CA  . PHE A 1 146 ? -32.20800 30.55774 6.86660   1.000 53.37110  ? 146 PHE A CA  1 
ATOM   1005 C C   . PHE A 1 146 ? -33.64004 30.90338 6.48557   1.000 64.53051  ? 146 PHE A C   1 
ATOM   1006 O O   . PHE A 1 146 ? -34.24725 30.26846 5.61547   1.000 62.93521  ? 146 PHE A O   1 
ATOM   1007 C CB  . PHE A 1 146 ? -31.15887 31.41665 6.15246   1.000 57.53831  ? 146 PHE A CB  1 
ATOM   1008 C CG  . PHE A 1 146 ? -29.83448 31.45163 6.88134   1.000 67.23108  ? 146 PHE A CG  1 
ATOM   1009 C CD1 . PHE A 1 146 ? -28.99397 30.33382 6.89708   1.000 54.69681  ? 146 PHE A CD1 1 
ATOM   1010 C CD2 . PHE A 1 146 ? -29.44860 32.58256 7.59577   1.000 55.90059  ? 146 PHE A CD2 1 
ATOM   1011 C CE1 . PHE A 1 146 ? -27.79134 30.36109 7.60451   1.000 61.76772  ? 146 PHE A CE1 1 
ATOM   1012 C CE2 . PHE A 1 146 ? -28.24141 32.61192 8.30144   1.000 59.33919  ? 146 PHE A CE2 1 
ATOM   1013 C CZ  . PHE A 1 146 ? -27.41330 31.50741 8.31646   1.000 48.91391  ? 146 PHE A CZ  1 
ATOM   1014 N N   . VAL A 1 147 ? -34.20188 31.87856 7.20349   1.000 56.34794  ? 147 VAL A N   1 
ATOM   1015 C CA  . VAL A 1 147 ? -35.59412 32.26831 7.06604   1.000 51.05199  ? 147 VAL A CA  1 
ATOM   1016 C C   . VAL A 1 147 ? -35.60709 33.77765 7.01400   1.000 64.45024  ? 147 VAL A C   1 
ATOM   1017 O O   . VAL A 1 147 ? -34.76234 34.41509 7.64889   1.000 69.35309  ? 147 VAL A O   1 
ATOM   1018 C CB  . VAL A 1 147 ? -36.44132 31.74241 8.23991   1.000 54.05515  ? 147 VAL A CB  1 
ATOM   1019 C CG1 . VAL A 1 147 ? -37.85178 32.30568 8.20068   1.000 54.29113  ? 147 VAL A CG1 1 
ATOM   1020 C CG2 . VAL A 1 147 ? -36.47449 30.23086 8.22229   1.000 59.06069  ? 147 VAL A CG2 1 
ATOM   1021 N N   . GLN A 1 148 ? -36.52288 34.34208 6.22841   1.000 54.77840  ? 148 GLN A N   1 
ATOM   1022 C CA  . GLN A 1 148 ? -36.68971 35.78092 6.17328   1.000 58.42031  ? 148 GLN A CA  1 
ATOM   1023 C C   . GLN A 1 148 ? -37.14918 36.30645 7.52776   1.000 57.22668  ? 148 GLN A C   1 
ATOM   1024 O O   . GLN A 1 148 ? -38.11411 35.79700 8.10729   1.000 63.53167  ? 148 GLN A O   1 
ATOM   1025 C CB  . GLN A 1 148 ? -37.71317 36.12692 5.09491   1.000 74.38683  ? 148 GLN A CB  1 
ATOM   1026 C CG  . GLN A 1 148 ? -38.20202 37.55211 5.14709   1.000 67.06613  ? 148 GLN A CG  1 
ATOM   1027 C CD  . GLN A 1 148 ? -37.16617 38.50887 4.58765   1.000 86.37772  ? 148 GLN A CD  1 
ATOM   1028 O OE1 . GLN A 1 148 ? -36.51294 38.20060 3.58982   1.000 76.41332  ? 148 GLN A OE1 1 
ATOM   1029 N NE2 . GLN A 1 148 ? -36.98502 39.65924 5.24215   1.000 77.99825  ? 148 GLN A NE2 1 
ATOM   1030 N N   . SER A 1 149 ? -36.46423 37.33681 8.02492   1.000 62.84311  ? 149 SER A N   1 
ATOM   1031 C CA  . SER A 1 149 ? -36.76863 37.97939 9.29782   1.000 77.53862  ? 149 SER A CA  1 
ATOM   1032 C C   . SER A 1 149 ? -37.47741 39.31711 9.07952   1.000 81.26940  ? 149 SER A C   1 
ATOM   1033 O O   . SER A 1 149 ? -37.74370 39.73953 7.94869   1.000 67.16796  ? 149 SER A O   1 
ATOM   1034 C CB  . SER A 1 149 ? -35.50099 38.23951 10.09617  1.000 65.90925  ? 149 SER A CB  1 
ATOM   1035 O OG  . SER A 1 149 ? -34.62478 38.96342 9.26624   1.000 72.51956  ? 149 SER A OG  1 
ATOM   1036 N N   . VAL A 1 150 ? -37.74802 39.99676 10.20071  1.000 81.20616  ? 150 VAL A N   1 
ATOM   1037 C CA  . VAL A 1 150 ? -38.31765 41.33768 10.19062  1.000 70.64967  ? 150 VAL A CA  1 
ATOM   1038 C C   . VAL A 1 150 ? -37.27141 42.43084 10.40339  1.000 85.94388  ? 150 VAL A C   1 
ATOM   1039 O O   . VAL A 1 150 ? -37.58826 43.61211 10.19785  1.000 105.15512 ? 150 VAL A O   1 
ATOM   1040 C CB  . VAL A 1 150 ? -39.42306 41.47138 11.25895  1.000 88.20811  ? 150 VAL A CB  1 
ATOM   1041 C CG1 . VAL A 1 150 ? -40.30872 42.69430 10.97151  1.000 97.43855  ? 150 VAL A CG1 1 
ATOM   1042 C CG2 . VAL A 1 150 ? -40.25679 40.20449 11.34984  1.000 72.52440  ? 150 VAL A CG2 1 
ATOM   1043 N N   . VAL A 1 151 ? -36.04471 42.07945 10.81797  1.000 88.95654  ? 151 VAL A N   1 
ATOM   1044 C CA  . VAL A 1 151 ? -35.03026 43.09842 11.09969  1.000 95.93318  ? 151 VAL A CA  1 
ATOM   1045 C C   . VAL A 1 151 ? -34.76775 43.94720 9.85253   1.000 98.00098  ? 151 VAL A C   1 
ATOM   1046 O O   . VAL A 1 151 ? -34.81153 45.18414 9.90113   1.000 103.60190 ? 151 VAL A O   1 
ATOM   1047 C CB  . VAL A 1 151 ? -33.73762 42.45171 11.64925  1.000 75.83011  ? 151 VAL A CB  1 
ATOM   1048 C CG1 . VAL A 1 151 ? -33.55526 42.77639 13.12538  1.000 68.67279  ? 151 VAL A CG1 1 
ATOM   1049 C CG2 . VAL A 1 151 ? -33.76846 40.95726 11.47871  1.000 82.46991  ? 151 VAL A CG2 1 
ATOM   1050 N N   . ALA A 1 152 ? -34.52264 43.29951 8.71316   1.000 83.09689  ? 152 ALA A N   1 
ATOM   1051 C CA  . ALA A 1 152 ? -34.31447 43.98536 7.43865   1.000 90.64568  ? 152 ALA A CA  1 
ATOM   1052 C C   . ALA A 1 152 ? -34.72276 43.04837 6.30154   1.000 83.74989  ? 152 ALA A C   1 
ATOM   1053 O O   . ALA A 1 152 ? -34.64122 41.82911 6.45912   1.000 81.07423  ? 152 ALA A O   1 
ATOM   1054 C CB  . ALA A 1 152 ? -32.85418 44.42651 7.25767   1.000 74.67407  ? 152 ALA A CB  1 
ATOM   1055 N N   . PRO A 1 153 ? -35.16039 43.58942 5.16210   1.000 82.05514  ? 153 PRO A N   1 
ATOM   1056 C CA  . PRO A 1 153 ? -35.69173 42.70216 4.10898   1.000 78.69292  ? 153 PRO A CA  1 
ATOM   1057 C C   . PRO A 1 153 ? -34.67203 41.73970 3.52197   1.000 82.74692  ? 153 PRO A C   1 
ATOM   1058 O O   . PRO A 1 153 ? -35.07756 40.67801 3.02639   1.000 89.50367  ? 153 PRO A O   1 
ATOM   1059 C CB  . PRO A 1 153 ? -36.22046 43.68745 3.05419   1.000 86.50402  ? 153 PRO A CB  1 
ATOM   1060 C CG  . PRO A 1 153 ? -35.52812 44.97741 3.35014   1.000 83.42791  ? 153 PRO A CG  1 
ATOM   1061 C CD  . PRO A 1 153 ? -35.35856 45.00802 4.83237   1.000 85.66094  ? 153 PRO A CD  1 
ATOM   1062 N N   . ASN A 1 154 ? -33.37267 42.06683 3.55244   1.000 78.56409  ? 154 ASN A N   1 
ATOM   1063 C CA  . ASN A 1 154 ? -32.31258 41.13691 3.15750   1.000 74.91931  ? 154 ASN A CA  1 
ATOM   1064 C C   . ASN A 1 154 ? -31.70302 40.38043 4.33686   1.000 72.75702  ? 154 ASN A C   1 
ATOM   1065 O O   . ASN A 1 154 ? -30.82762 39.54084 4.11531   1.000 76.54794  ? 154 ASN A O   1 
ATOM   1066 C CB  . ASN A 1 154 ? -31.18298 41.87972 2.40962   1.000 85.24126  ? 154 ASN A CB  1 
ATOM   1067 C CG  . ASN A 1 154 ? -31.65953 42.56356 1.11653   1.000 93.30348  ? 154 ASN A CG  1 
ATOM   1068 O OD1 . ASN A 1 154 ? -31.86753 41.92301 0.07950   1.000 89.10394  ? 154 ASN A OD1 1 
ATOM   1069 N ND2 . ASN A 1 154 ? -31.85365 43.87979 1.19654   1.000 80.55031  ? 154 ASN A ND2 1 
ATOM   1070 N N   . THR A 1 155 ? -32.11800 40.67483 5.57473   1.000 70.18527  ? 155 THR A N   1 
ATOM   1071 C CA  . THR A 1 155 ? -31.65254 39.95256 6.75732   1.000 65.93849  ? 155 THR A CA  1 
ATOM   1072 C C   . THR A 1 155 ? -32.48091 38.68340 6.97025   1.000 73.93601  ? 155 THR A C   1 
ATOM   1073 O O   . THR A 1 155 ? -33.69160 38.74592 7.21234   1.000 64.28987  ? 155 THR A O   1 
ATOM   1074 C CB  . THR A 1 155 ? -31.70769 40.83419 8.00903   1.000 62.83489  ? 155 THR A CB  1 
ATOM   1075 O OG1 . THR A 1 155 ? -30.95084 42.04359 7.80415   1.000 72.70747  ? 155 THR A OG1 1 
ATOM   1076 C CG2 . THR A 1 155 ? -31.16175 40.08065 9.22225   1.000 68.39504  ? 155 THR A CG2 1 
ATOM   1077 N N   . LEU A 1 156 ? -31.81355 37.53391 6.87888   1.000 74.71449  ? 156 LEU A N   1 
ATOM   1078 C CA  . LEU A 1 156 ? -32.36152 36.22109 7.17764   1.000 63.45947  ? 156 LEU A CA  1 
ATOM   1079 C C   . LEU A 1 156 ? -31.79585 35.71022 8.49646   1.000 64.39702  ? 156 LEU A C   1 
ATOM   1080 O O   . LEU A 1 156 ? -30.65536 36.01047 8.84767   1.000 69.79980  ? 156 LEU A O   1 
ATOM   1081 C CB  . LEU A 1 156 ? -32.01640 35.24090 6.04696   1.000 65.00269  ? 156 LEU A CB  1 
ATOM   1082 C CG  . LEU A 1 156 ? -32.43327 35.76404 4.65310   1.000 83.46683  ? 156 LEU A CG  1 
ATOM   1083 C CD1 . LEU A 1 156 ? -31.26871 35.87098 3.67489   1.000 64.32453  ? 156 LEU A CD1 1 
ATOM   1084 C CD2 . LEU A 1 156 ? -33.54494 34.90547 4.04828   1.000 80.71361  ? 156 LEU A CD2 1 
ATOM   1085 N N   . PHE A 1 157 ? -32.57983 34.92243 9.23001   1.000 71.09306  ? 157 PHE A N   1 
ATOM   1086 C CA  . PHE A 1 157 ? -32.07845 34.34748 10.47336  1.000 55.88131  ? 157 PHE A CA  1 
ATOM   1087 C C   . PHE A 1 157 ? -32.21798 32.82701 10.46375  1.000 57.86883  ? 157 PHE A C   1 
ATOM   1088 O O   . PHE A 1 157 ? -33.14009 32.27970 9.85279   1.000 61.85372  ? 157 PHE A O   1 
ATOM   1089 C CB  . PHE A 1 157 ? -32.80641 34.91929 11.66555  1.000 45.88137  ? 157 PHE A CB  1 
ATOM   1090 C CG  . PHE A 1 157 ? -34.11521 34.29916 11.88979  1.000 51.31927  ? 157 PHE A CG  1 
ATOM   1091 C CD1 . PHE A 1 157 ? -35.15057 34.61076 11.05621  1.000 57.32502  ? 157 PHE A CD1 1 
ATOM   1092 C CD2 . PHE A 1 157 ? -34.34190 33.43846 12.95527  1.000 68.54618  ? 157 PHE A CD2 1 
ATOM   1093 C CE1 . PHE A 1 157 ? -36.40071 34.04974 11.23818  1.000 59.60214  ? 157 PHE A CE1 1 
ATOM   1094 C CE2 . PHE A 1 157 ? -35.61332 32.86635 13.15862  1.000 47.76525  ? 157 PHE A CE2 1 
ATOM   1095 C CZ  . PHE A 1 157 ? -36.63800 33.18271 12.29281  1.000 54.01079  ? 157 PHE A CZ  1 
ATOM   1096 N N   . TYR A 1 158 ? -31.26354 32.17155 11.12246  1.000 49.63797  ? 158 TYR A N   1 
ATOM   1097 C CA  . TYR A 1 158 ? -31.20765 30.74180 11.40378  1.000 45.70943  ? 158 TYR A CA  1 
ATOM   1098 C C   . TYR A 1 158 ? -31.23406 30.56890 12.92064  1.000 50.30960  ? 158 TYR A C   1 
ATOM   1099 O O   . TYR A 1 158 ? -30.21754 30.79917 13.58359  1.000 44.57966  ? 158 TYR A O   1 
ATOM   1100 C CB  . TYR A 1 158 ? -29.91098 30.15644 10.83755  1.000 53.38950  ? 158 TYR A CB  1 
ATOM   1101 C CG  . TYR A 1 158 ? -29.73689 28.64617 10.90729  1.000 50.41705  ? 158 TYR A CG  1 
ATOM   1102 C CD1 . TYR A 1 158 ? -29.32058 28.01611 12.07588  1.000 52.35608  ? 158 TYR A CD1 1 
ATOM   1103 C CD2 . TYR A 1 158 ? -29.90689 27.87202 9.77350   1.000 46.28239  ? 158 TYR A CD2 1 
ATOM   1104 C CE1 . TYR A 1 158 ? -29.12446 26.63813 12.12544  1.000 46.80680  ? 158 TYR A CE1 1 
ATOM   1105 C CE2 . TYR A 1 158 ? -29.71092 26.50997 9.80391   1.000 54.64652  ? 158 TYR A CE2 1 
ATOM   1106 C CZ  . TYR A 1 158 ? -29.32635 25.88627 10.98432  1.000 54.57269  ? 158 TYR A CZ  1 
ATOM   1107 O OH  . TYR A 1 158 ? -29.14502 24.51482 10.97639  1.000 48.67955  ? 158 TYR A OH  1 
ATOM   1108 N N   . LYS A 1 159 ? -32.37355 30.14176 13.47237  1.000 49.76484  ? 159 LYS A N   1 
ATOM   1109 C CA  . LYS A 1 159 ? -32.50180 29.99169 14.92593  1.000 48.64711  ? 159 LYS A CA  1 
ATOM   1110 C C   . LYS A 1 159 ? -31.58775 28.88998 15.47133  1.000 50.61750  ? 159 LYS A C   1 
ATOM   1111 O O   . LYS A 1 159 ? -31.33950 27.88143 14.81079  1.000 55.05711  ? 159 LYS A O   1 
ATOM   1112 C CB  . LYS A 1 159 ? -33.95954 29.70554 15.28920  1.000 47.00280  ? 159 LYS A CB  1 
ATOM   1113 C CG  . LYS A 1 159 ? -34.29422 29.65489 16.76680  1.000 49.72492  ? 159 LYS A CG  1 
ATOM   1114 C CD  . LYS A 1 159 ? -35.81568 29.55836 16.96573  1.000 48.57889  ? 159 LYS A CD  1 
ATOM   1115 C CE  . LYS A 1 159 ? -36.13056 28.97090 18.32609  1.000 58.50165  ? 159 LYS A CE  1 
ATOM   1116 N NZ  . LYS A 1 159 ? -37.38190 29.46840 18.94025  1.000 52.96506  ? 159 LYS A NZ  1 
ATOM   1117 N N   . VAL A 1 160 ? -31.07779 29.08608 16.68539  1.000 59.35919  ? 160 VAL A N   1 
ATOM   1118 C CA  . VAL A 1 160 ? -30.12304 28.17316 17.30631  1.000 54.31726  ? 160 VAL A CA  1 
ATOM   1119 C C   . VAL A 1 160 ? -30.83761 27.42493 18.42266  1.000 63.09691  ? 160 VAL A C   1 
ATOM   1120 O O   . VAL A 1 160 ? -31.43725 28.04178 19.31158  1.000 73.00255  ? 160 VAL A O   1 
ATOM   1121 C CB  . VAL A 1 160 ? -28.89109 28.93271 17.85610  1.000 57.98392  ? 160 VAL A CB  1 
ATOM   1122 C CG1 . VAL A 1 160 ? -28.02501 28.04626 18.75581  1.000 53.50892  ? 160 VAL A CG1 1 
ATOM   1123 C CG2 . VAL A 1 160 ? -28.05270 29.55095 16.74383  1.000 49.23571  ? 160 VAL A CG2 1 
ATOM   1124 N N   . LEU A 1 161 ? -30.74306 26.10429 18.40580  1.000 79.03018  ? 161 LEU A N   1 
ATOM   1125 C CA  . LEU A 1 161 ? -31.23089 25.26842 19.49389  1.000 68.89625  ? 161 LEU A CA  1 
ATOM   1126 C C   . LEU A 1 161 ? -30.05042 24.64912 20.23162  1.000 87.77214  ? 161 LEU A C   1 
ATOM   1127 O O   . LEU A 1 161 ? -29.01136 24.35194 19.62596  1.000 82.73589  ? 161 LEU A O   1 
ATOM   1128 C CB  . LEU A 1 161 ? -32.13775 24.17446 18.94514  1.000 69.50609  ? 161 LEU A CB  1 
ATOM   1129 C CG  . LEU A 1 161 ? -33.07516 24.83451 17.92641  1.000 79.53314  ? 161 LEU A CG  1 
ATOM   1130 C CD1 . LEU A 1 161 ? -33.41640 23.84965 16.83052  1.000 81.45449  ? 161 LEU A CD1 1 
ATOM   1131 C CD2 . LEU A 1 161 ? -34.34505 25.46286 18.53564  1.000 80.54047  ? 161 LEU A CD2 1 
ATOM   1132 N N   . GLU A 1 162 ? -30.22239 24.45364 21.54428  1.000 102.63424 ? 162 GLU A N   1 
ATOM   1133 C CA  . GLU A 1 162 ? -29.16572 23.90176 22.39606  1.000 116.35683 ? 162 GLU A CA  1 
ATOM   1134 C C   . GLU A 1 162 ? -28.66806 22.54281 21.87833  1.000 113.20663 ? 162 GLU A C   1 
ATOM   1135 O O   . GLU A 1 162 ? -29.43679 21.73766 21.34684  1.000 112.69779 ? 162 GLU A O   1 
ATOM   1136 C CB  . GLU A 1 162 ? -29.66962 23.76832 23.84802  1.000 104.57856 ? 162 GLU A CB  1 
ATOM   1137 C CG  . GLU A 1 162 ? -30.52019 22.51298 24.18781  1.000 116.48234 ? 162 GLU A CG  1 
ATOM   1138 C CD  . GLU A 1 162 ? -31.89949 22.45953 23.51683  1.000 124.52219 ? 162 GLU A CD  1 
ATOM   1139 O OE1 . GLU A 1 162 ? -32.50059 23.53327 23.27770  1.000 125.07108 ? 162 GLU A OE1 1 
ATOM   1140 O OE2 . GLU A 1 162 ? -32.38775 21.33293 23.24715  1.000 130.10451 ? 162 GLU A OE2 1 
ATOM   1141 N N   . HIS A 1 163 ? -27.35771 22.29827 22.02759  1.000 117.33624 ? 163 HIS A N   1 
ATOM   1142 C CA  . HIS A 1 163 ? -26.75311 21.00861 21.67549  1.000 114.49116 ? 163 HIS A CA  1 
ATOM   1143 C C   . HIS A 1 163 ? -27.14699 19.95187 22.71554  1.000 127.83367 ? 163 HIS A C   1 
ATOM   1144 O O   . HIS A 1 163 ? -27.19713 20.23147 23.91878  1.000 126.04316 ? 163 HIS A O   1 
ATOM   1145 C CB  . HIS A 1 163 ? -25.21345 21.16278 21.57130  1.000 113.95000 ? 163 HIS A CB  1 
ATOM   1146 C CG  . HIS A 1 163 ? -24.50950 20.13484 20.71707  1.000 122.39819 ? 163 HIS A CG  1 
ATOM   1147 N ND1 . HIS A 1 163 ? -23.14452 19.93338 20.78319  1.000 105.37757 ? 163 HIS A ND1 1 
ATOM   1148 C CD2 . HIS A 1 163 ? -24.96580 19.27024 19.77731  1.000 124.39684 ? 163 HIS A CD2 1 
ATOM   1149 C CE1 . HIS A 1 163 ? -22.79314 18.98480 19.93317  1.000 115.08267 ? 163 HIS A CE1 1 
ATOM   1150 N NE2 . HIS A 1 163 ? -23.87935 18.56607 19.30855  1.000 113.16315 ? 163 HIS A NE2 1 
ATOM   1151 N N   . HIS A 1 164 ? -27.45905 18.74143 22.23696  1.000 130.39956 ? 164 HIS A N   1 
ATOM   1152 C CA  . HIS A 1 164 ? -27.95194 17.62264 23.06595  1.000 119.27783 ? 164 HIS A CA  1 
ATOM   1153 C C   . HIS A 1 164 ? -29.25243 17.97843 23.80519  1.000 117.16028 ? 164 HIS A C   1 
ATOM   1154 O O   . HIS A 1 164 ? -30.30656 18.19424 23.19183  1.000 101.54552 ? 164 HIS A O   1 
ATOM   1155 C CB  . HIS A 1 164 ? -26.88221 17.18237 24.07808  1.000 111.86188 ? 164 HIS A CB  1 
ATOM   1156 C CG  . HIS A 1 164 ? -26.16804 15.91664 23.70610  1.000 113.76392 ? 164 HIS A CG  1 
ATOM   1157 N ND1 . HIS A 1 164 ? -26.81305 14.71099 23.53265  1.000 120.21274 ? 164 HIS A ND1 1 
ATOM   1158 C CD2 . HIS A 1 164 ? -24.85810 15.67947 23.45163  1.000 127.92536 ? 164 HIS A CD2 1 
ATOM   1159 C CE1 . HIS A 1 164 ? -25.93031 13.78266 23.20398  1.000 128.94204 ? 164 HIS A CE1 1 
ATOM   1160 N NE2 . HIS A 1 164 ? -24.73637 14.34523 23.14573  1.000 133.23516 ? 164 HIS A NE2 1 
ATOM   1161 N N   . GLN B 2 4   ? -23.29476 46.24623 10.04553  1.000 83.49944  ? 62  GLN B N   1 
ATOM   1162 C CA  . GLN B 2 4   ? -24.25713 46.39951 11.13737  1.000 81.30609  ? 62  GLN B CA  1 
ATOM   1163 C C   . GLN B 2 4   ? -24.27056 45.23354 12.13954  1.000 103.25955 ? 62  GLN B C   1 
ATOM   1164 O O   . GLN B 2 4   ? -24.34782 44.06576 11.73437  1.000 92.26029  ? 62  GLN B O   1 
ATOM   1165 C CB  . GLN B 2 4   ? -25.65756 46.54274 10.57231  1.000 84.69851  ? 62  GLN B CB  1 
ATOM   1166 C CG  . GLN B 2 4   ? -26.72424 46.79457 11.62235  1.000 87.33028  ? 62  GLN B CG  1 
ATOM   1167 C CD  . GLN B 2 4   ? -28.12932 46.70575 11.03403  1.000 113.08248 ? 62  GLN B CD  1 
ATOM   1168 O OE1 . GLN B 2 4   ? -29.12873 46.99332 11.71124  1.000 110.70850 ? 62  GLN B OE1 1 
ATOM   1169 N NE2 . GLN B 2 4   ? -28.21539 46.25346 9.77730   1.000 118.31650 ? 62  GLN B NE2 1 
ATOM   1170 N N   . ARG B 2 5   ? -24.25415 45.57575 13.44884  1.000 102.44745 ? 63  ARG B N   1 
ATOM   1171 C CA  . ARG B 2 5   ? -24.19864 44.58777 14.52652  1.000 81.51312  ? 63  ARG B CA  1 
ATOM   1172 C C   . ARG B 2 5   ? -25.18965 44.79362 15.67372  1.000 80.59461  ? 63  ARG B C   1 
ATOM   1173 O O   . ARG B 2 5   ? -25.22173 43.94927 16.57326  1.000 85.25853  ? 63  ARG B O   1 
ATOM   1174 C CB  . ARG B 2 5   ? -22.76899 44.52566 15.11476  1.000 71.65914  ? 63  ARG B CB  1 
ATOM   1175 C CG  . ARG B 2 5   ? -21.80331 43.77537 14.20442  1.000 73.53080  ? 63  ARG B CG  1 
ATOM   1176 C CD  . ARG B 2 5   ? -20.33668 43.74879 14.62609  1.000 89.02810  ? 63  ARG B CD  1 
ATOM   1177 N NE  . ARG B 2 5   ? -19.91127 44.86654 15.45983  1.000 77.31863  ? 63  ARG B NE  1 
ATOM   1178 C CZ  . ARG B 2 5   ? -19.95788 44.85509 16.78030  1.000 78.73275  ? 63  ARG B CZ  1 
ATOM   1179 N NH1 . ARG B 2 5   ? -20.48359 43.83181 17.44057  1.000 80.66905  ? 63  ARG B NH1 1 
ATOM   1180 N NH2 . ARG B 2 5   ? -19.44610 45.88000 17.45134  1.000 77.08774  ? 63  ARG B NH2 1 
ATOM   1181 N N   . LEU B 2 6   ? -25.98585 45.87120 15.69808  1.000 78.16251  ? 64  LEU B N   1 
ATOM   1182 C CA  . LEU B 2 6   ? -26.97368 46.08297 16.77093  1.000 75.05992  ? 64  LEU B CA  1 
ATOM   1183 C C   . LEU B 2 6   ? -28.26154 46.57078 16.12159  1.000 90.27467  ? 64  LEU B C   1 
ATOM   1184 O O   . LEU B 2 6   ? -28.36001 47.73066 15.71992  1.000 95.10311  ? 64  LEU B O   1 
ATOM   1185 C CB  . LEU B 2 6   ? -26.48769 47.05897 17.84430  1.000 68.24589  ? 64  LEU B CB  1 
ATOM   1186 C CG  . LEU B 2 6   ? -27.47590 47.63368 18.88145  1.000 76.06270  ? 64  LEU B CG  1 
ATOM   1187 C CD1 . LEU B 2 6   ? -27.68136 46.73876 20.09951  1.000 76.08901  ? 64  LEU B CD1 1 
ATOM   1188 C CD2 . LEU B 2 6   ? -27.05152 49.03852 19.33744  1.000 73.97193  ? 64  LEU B CD2 1 
ATOM   1189 N N   . PHE B 2 7   ? -29.24363 45.68394 16.01674  1.000 99.92186  ? 65  PHE B N   1 
ATOM   1190 C CA  . PHE B 2 7   ? -30.49900 46.01778 15.36378  1.000 91.19529  ? 65  PHE B CA  1 
ATOM   1191 C C   . PHE B 2 7   ? -31.41786 46.63267 16.41310  1.000 98.01583  ? 65  PHE B C   1 
ATOM   1192 O O   . PHE B 2 7   ? -31.81953 45.96492 17.37442  1.000 98.79997  ? 65  PHE B O   1 
ATOM   1193 C CB  . PHE B 2 7   ? -31.10394 44.78263 14.71005  1.000 71.56739  ? 65  PHE B CB  1 
ATOM   1194 C CG  . PHE B 2 7   ? -30.22214 44.16518 13.65752  1.000 75.88477  ? 65  PHE B CG  1 
ATOM   1195 C CD1 . PHE B 2 7   ? -29.13421 43.39998 14.00948  1.000 74.41545  ? 65  PHE B CD1 1 
ATOM   1196 C CD2 . PHE B 2 7   ? -30.47548 44.36392 12.31338  1.000 104.07943 ? 65  PHE B CD2 1 
ATOM   1197 C CE1 . PHE B 2 7   ? -28.31745 42.82850 13.03084  1.000 99.00902  ? 65  PHE B CE1 1 
ATOM   1198 C CE2 . PHE B 2 7   ? -29.65767 43.79461 11.32712  1.000 97.28956  ? 65  PHE B CE2 1 
ATOM   1199 C CZ  . PHE B 2 7   ? -28.58086 43.02961 11.69018  1.000 95.66013  ? 65  PHE B CZ  1 
ATOM   1200 N N   . VAL B 2 8   ? -31.70258 47.92027 16.26345  1.000 81.86942  ? 66  VAL B N   1 
ATOM   1201 C CA  . VAL B 2 8   ? -32.61370 48.62004 17.15460  1.000 77.62421  ? 66  VAL B CA  1 
ATOM   1202 C C   . VAL B 2 8   ? -33.92676 48.77368 16.41204  1.000 92.05938  ? 66  VAL B C   1 
ATOM   1203 O O   . VAL B 2 8   ? -33.95606 49.26007 15.27393  1.000 106.36080 ? 66  VAL B O   1 
ATOM   1204 C CB  . VAL B 2 8   ? -32.04687 49.97278 17.59819  1.000 85.69219  ? 66  VAL B CB  1 
ATOM   1205 C CG1 . VAL B 2 8   ? -32.72069 50.40855 18.89051  1.000 97.98864  ? 66  VAL B CG1 1 
ATOM   1206 C CG2 . VAL B 2 8   ? -30.55330 49.85765 17.78120  1.000 82.64031  ? 66  VAL B CG2 1 
ATOM   1207 N N   . LEU B 2 9   ? -35.00421 48.32136 17.03484  1.000 85.69211  ? 67  LEU B N   1 
ATOM   1208 C CA  . LEU B 2 9   ? -36.28079 48.20347 16.36110  1.000 87.77537  ? 67  LEU B CA  1 
ATOM   1209 C C   . LEU B 2 9   ? -37.34829 48.90091 17.18587  1.000 88.14962  ? 67  LEU B C   1 
ATOM   1210 O O   . LEU B 2 9   ? -37.29934 48.90202 18.42061  1.000 81.87855  ? 67  LEU B O   1 
ATOM   1211 C CB  . LEU B 2 9   ? -36.64782 46.72920 16.14313  1.000 76.90761  ? 67  LEU B CB  1 
ATOM   1212 C CG  . LEU B 2 9   ? -35.76437 45.98158 15.14441  1.000 76.58275  ? 67  LEU B CG  1 
ATOM   1213 C CD1 . LEU B 2 9   ? -36.45939 44.71819 14.69362  1.000 85.00321  ? 67  LEU B CD1 1 
ATOM   1214 C CD2 . LEU B 2 9   ? -35.37928 46.83572 13.93810  1.000 84.08643  ? 67  LEU B CD2 1 
ATOM   1215 N N   . ASP B 2 10  ? -38.30350 49.51219 16.48331  1.000 83.15525  ? 68  ASP B N   1 
ATOM   1216 C CA  . ASP B 2 10  ? -39.51182 50.01981 17.11718  1.000 81.52463  ? 68  ASP B CA  1 
ATOM   1217 C C   . ASP B 2 10  ? -40.22595 48.88088 17.85217  1.000 95.64802  ? 68  ASP B C   1 
ATOM   1218 O O   . ASP B 2 10  ? -39.91483 47.69514 17.67249  1.000 117.94375 ? 68  ASP B O   1 
ATOM   1219 C CB  . ASP B 2 10  ? -40.40119 50.70201 16.07086  1.000 79.30785  ? 68  ASP B CB  1 
ATOM   1220 C CG  . ASP B 2 10  ? -41.11661 49.71349 15.12810  1.000 102.57536 ? 68  ASP B CG  1 
ATOM   1221 O OD1 . ASP B 2 10  ? -41.04605 49.92940 13.89439  1.000 107.46786 ? 68  ASP B OD1 1 
ATOM   1222 O OD2 . ASP B 2 10  ? -41.78472 48.75664 15.59494  1.000 96.67885  ? 68  ASP B OD2 1 
ATOM   1223 N N   . ASN B 2 11  ? -41.20723 49.24514 18.68078  1.000 81.03483  ? 69  ASN B N   1 
ATOM   1224 C CA  . ASN B 2 11  ? -41.84000 48.25572 19.55351  1.000 83.31916  ? 69  ASN B CA  1 
ATOM   1225 C C   . ASN B 2 11  ? -42.51861 47.14985 18.76219  1.000 84.11304  ? 69  ASN B C   1 
ATOM   1226 O O   . ASN B 2 11  ? -42.49469 45.97781 19.16392  1.000 85.55150  ? 69  ASN B O   1 
ATOM   1227 C CB  . ASN B 2 11  ? -42.85174 48.93991 20.45949  1.000 92.97007  ? 69  ASN B CB  1 
ATOM   1228 C CG  . ASN B 2 11  ? -42.27806 49.26718 21.80697  1.000 105.10063 ? 69  ASN B CG  1 
ATOM   1229 O OD1 . ASN B 2 11  ? -41.17100 49.79934 21.91088  1.000 92.77498  ? 69  ASN B OD1 1 
ATOM   1230 N ND2 . ASN B 2 11  ? -43.03605 48.95401 22.86263  1.000 98.72368  ? 69  ASN B ND2 1 
ATOM   1231 N N   . GLU B 2 12  ? -43.13445 47.50644 17.63547  1.000 96.48588  ? 70  GLU B N   1 
ATOM   1232 C CA  . GLU B 2 12  ? -43.91763 46.54457 16.86696  1.000 90.87376  ? 70  GLU B CA  1 
ATOM   1233 C C   . GLU B 2 12  ? -43.03143 45.62044 16.04065  1.000 87.64756  ? 70  GLU B C   1 
ATOM   1234 O O   . GLU B 2 12  ? -43.29386 44.41608 15.98311  1.000 72.83347  ? 70  GLU B O   1 
ATOM   1235 C CB  . GLU B 2 12  ? -44.93457 47.26146 15.96448  1.000 80.22211  ? 70  GLU B CB  1 
ATOM   1236 C CG  . GLU B 2 12  ? -45.93787 48.22127 16.64232  1.000 92.82641  ? 70  GLU B CG  1 
ATOM   1237 C CD  . GLU B 2 12  ? -45.32533 49.35280 17.47638  1.000 115.24153 ? 70  GLU B CD  1 
ATOM   1238 O OE1 . GLU B 2 12  ? -46.00339 49.87001 18.39418  1.000 107.11248 ? 70  GLU B OE1 1 
ATOM   1239 O OE2 . GLU B 2 12  ? -44.16818 49.74754 17.18170  1.000 113.86819 ? 70  GLU B OE2 1 
ATOM   1240 N N   . ARG B 2 13  ? -41.99646 46.15846 15.38312  1.000 82.95823  ? 71  ARG B N   1 
ATOM   1241 C CA  . ARG B 2 13  ? -41.01718 45.28233 14.75075  1.000 82.34085  ? 71  ARG B CA  1 
ATOM   1242 C C   . ARG B 2 13  ? -40.37002 44.36257 15.78287  1.000 92.84310  ? 71  ARG B C   1 
ATOM   1243 O O   . ARG B 2 13  ? -40.11768 43.18355 15.49454  1.000 80.90959  ? 71  ARG B O   1 
ATOM   1244 C CB  . ARG B 2 13  ? -39.95019 46.09824 14.00161  1.000 73.27894  ? 71  ARG B CB  1 
ATOM   1245 C CG  . ARG B 2 13  ? -40.24784 46.38615 12.51662  1.000 72.03081  ? 71  ARG B CG  1 
ATOM   1246 C CD  . ARG B 2 13  ? -39.08320 47.13095 11.84273  1.000 76.93107  ? 71  ARG B CD  1 
ATOM   1247 N NE  . ARG B 2 13  ? -39.53975 48.36387 11.20482  1.000 109.96602 ? 71  ARG B NE  1 
ATOM   1248 C CZ  . ARG B 2 13  ? -39.26563 49.58584 11.65086  1.000 101.49309 ? 71  ARG B CZ  1 
ATOM   1249 N NH1 . ARG B 2 13  ? -38.47459 49.77658 12.69792  1.000 89.75782  ? 71  ARG B NH1 1 
ATOM   1250 N NH2 . ARG B 2 13  ? -39.82407 50.63802 11.05242  1.000 86.48031  ? 71  ARG B NH2 1 
ATOM   1251 N N   . TYR B 2 14  ? -40.14273 44.85935 17.00452  1.000 89.06534  ? 72  TYR B N   1 
ATOM   1252 C CA  . TYR B 2 14  ? -39.48955 44.02327 18.00845  1.000 86.93931  ? 72  TYR B CA  1 
ATOM   1253 C C   . TYR B 2 14  ? -40.36853 42.83786 18.40477  1.000 82.43435  ? 72  TYR B C   1 
ATOM   1254 O O   . TYR B 2 14  ? -39.88002 41.70467 18.48849  1.000 86.84719  ? 72  TYR B O   1 
ATOM   1255 C CB  . TYR B 2 14  ? -39.10530 44.85023 19.24147  1.000 74.35482  ? 72  TYR B CB  1 
ATOM   1256 C CG  . TYR B 2 14  ? -38.28299 44.07041 20.25982  1.000 84.59286  ? 72  TYR B CG  1 
ATOM   1257 C CD1 . TYR B 2 14  ? -36.94002 43.75930 20.03200  1.000 73.97864  ? 72  TYR B CD1 1 
ATOM   1258 C CD2 . TYR B 2 14  ? -38.86220 43.62016 21.44054  1.000 82.74619  ? 72  TYR B CD2 1 
ATOM   1259 C CE1 . TYR B 2 14  ? -36.20180 43.03608 20.97739  1.000 70.80487  ? 72  TYR B CE1 1 
ATOM   1260 C CE2 . TYR B 2 14  ? -38.13081 42.91628 22.37977  1.000 73.03604  ? 72  TYR B CE2 1 
ATOM   1261 C CZ  . TYR B 2 14  ? -36.81252 42.62770 22.14678  1.000 70.05210  ? 72  TYR B CZ  1 
ATOM   1262 O OH  . TYR B 2 14  ? -36.12564 41.91575 23.09845  1.000 79.22310  ? 72  TYR B OH  1 
ATOM   1263 N N   . ASP B 2 15  ? -41.66955 43.06508 18.62480  1.000 89.55248  ? 73  ASP B N   1 
ATOM   1264 C CA  . ASP B 2 15  ? -42.56709 41.95201 18.94340  1.000 84.31305  ? 73  ASP B CA  1 
ATOM   1265 C C   . ASP B 2 15  ? -42.67958 40.96599 17.78208  1.000 74.55487  ? 73  ASP B C   1 
ATOM   1266 O O   . ASP B 2 15  ? -42.74534 39.75150 18.00473  1.000 83.45276  ? 73  ASP B O   1 
ATOM   1267 C CB  . ASP B 2 15  ? -43.94241 42.48551 19.34206  1.000 78.09920  ? 73  ASP B CB  1 
ATOM   1268 C CG  . ASP B 2 15  ? -43.86052 43.49661 20.46397  1.000 76.82486  ? 73  ASP B CG  1 
ATOM   1269 O OD1 . ASP B 2 15  ? -42.89760 43.42943 21.24725  1.000 90.10699  ? 73  ASP B OD1 1 
ATOM   1270 O OD2 . ASP B 2 15  ? -44.71759 44.39510 20.53781  1.000 83.20852  ? 73  ASP B OD2 1 
ATOM   1271 N N   . SER B 2 16  ? -42.68250 41.46147 16.53856  1.000 73.69544  ? 74  SER B N   1 
ATOM   1272 C CA  . SER B 2 16  ? -42.77986 40.57160 15.37996  1.000 71.44846  ? 74  SER B CA  1 
ATOM   1273 C C   . SER B 2 16  ? -41.53390 39.71650 15.23605  1.000 77.80565  ? 74  SER B C   1 
ATOM   1274 O O   . SER B 2 16  ? -41.61633 38.51877 14.93734  1.000 85.86780  ? 74  SER B O   1 
ATOM   1275 C CB  . SER B 2 16  ? -42.99755 41.37450 14.09764  1.000 79.24297  ? 74  SER B CB  1 
ATOM   1276 O OG  . SER B 2 16  ? -43.78705 42.52383 14.33477  1.000 83.70020  ? 74  SER B OG  1 
ATOM   1277 N N   . PHE B 2 17  ? -40.36900 40.32881 15.40617  1.000 80.94091  ? 75  PHE B N   1 
ATOM   1278 C CA  . PHE B 2 17  ? -39.12919 39.57643 15.47854  1.000 73.08607  ? 75  PHE B CA  1 
ATOM   1279 C C   . PHE B 2 17  ? -39.15567 38.58729 16.64123  1.000 70.70417  ? 75  PHE B C   1 
ATOM   1280 O O   . PHE B 2 17  ? -38.77673 37.41795 16.47999  1.000 69.17436  ? 75  PHE B O   1 
ATOM   1281 C CB  . PHE B 2 17  ? -37.97803 40.56881 15.59818  1.000 77.93798  ? 75  PHE B CB  1 
ATOM   1282 C CG  . PHE B 2 17  ? -36.67243 39.94519 15.86904  1.000 62.95567  ? 75  PHE B CG  1 
ATOM   1283 C CD1 . PHE B 2 17  ? -36.26115 39.74327 17.17376  1.000 64.58320  ? 75  PHE B CD1 1 
ATOM   1284 C CD2 . PHE B 2 17  ? -35.81752 39.64226 14.83650  1.000 60.63741  ? 75  PHE B CD2 1 
ATOM   1285 C CE1 . PHE B 2 17  ? -35.04674 39.18767 17.45042  1.000 61.33582  ? 75  PHE B CE1 1 
ATOM   1286 C CE2 . PHE B 2 17  ? -34.59973 39.08161 15.09549  1.000 64.79046  ? 75  PHE B CE2 1 
ATOM   1287 C CZ  . PHE B 2 17  ? -34.20790 38.85820 16.40953  1.000 76.11154  ? 75  PHE B CZ  1 
ATOM   1288 N N   . ILE B 2 18  ? -39.60859 39.02893 17.82049  1.000 70.63270  ? 76  ILE B N   1 
ATOM   1289 C CA  . ILE B 2 18  ? -39.59915 38.13604 18.97816  1.000 71.89795  ? 76  ILE B CA  1 
ATOM   1290 C C   . ILE B 2 18  ? -40.50560 36.93384 18.73041  1.000 69.42025  ? 76  ILE B C   1 
ATOM   1291 O O   . ILE B 2 18  ? -40.04920 35.78310 18.76806  1.000 75.31552  ? 76  ILE B O   1 
ATOM   1292 C CB  . ILE B 2 18  ? -39.97835 38.88375 20.26644  1.000 68.95849  ? 76  ILE B CB  1 
ATOM   1293 C CG1 . ILE B 2 18  ? -38.75174 39.58369 20.85122  1.000 61.12291  ? 76  ILE B CG1 1 
ATOM   1294 C CG2 . ILE B 2 18  ? -40.44860 37.87831 21.30972  1.000 74.69022  ? 76  ILE B CG2 1 
ATOM   1295 C CD1 . ILE B 2 18  ? -37.88474 38.68694 21.70149  1.000 61.11279  ? 76  ILE B CD1 1 
ATOM   1296 N N   . THR B 2 19  ? -41.78547 37.18349 18.41807  1.000 70.79237  ? 77  THR B N   1 
ATOM   1297 C CA  . THR B 2 19  ? -42.69532 36.07501 18.13327  1.000 79.70905  ? 77  THR B CA  1 
ATOM   1298 C C   . THR B 2 19  ? -42.14198 35.15152 17.05603  1.000 63.76844  ? 77  THR B C   1 
ATOM   1299 O O   . THR B 2 19  ? -42.21720 33.92591 17.19259  1.000 64.11712  ? 77  THR B O   1 
ATOM   1300 C CB  . THR B 2 19  ? -44.06146 36.57852 17.68867  1.000 67.04922  ? 77  THR B CB  1 
ATOM   1301 O OG1 . THR B 2 19  ? -43.89509 37.73760 16.86935  1.000 77.10717  ? 77  THR B OG1 1 
ATOM   1302 C CG2 . THR B 2 19  ? -44.94111 36.92662 18.88347  1.000 62.32860  ? 77  THR B CG2 1 
ATOM   1303 N N   . GLN B 2 20  ? -41.59957 35.70614 15.96628  1.000 59.15381  ? 78  GLN B N   1 
ATOM   1304 C CA  . GLN B 2 20  ? -41.13803 34.79999 14.93146  1.000 57.18686  ? 78  GLN B CA  1 
ATOM   1305 C C   . GLN B 2 20  ? -39.90342 34.02266 15.37582  1.000 69.98416  ? 78  GLN B C   1 
ATOM   1306 O O   . GLN B 2 20  ? -39.63694 32.95287 14.81398  1.000 79.48602  ? 78  GLN B O   1 
ATOM   1307 C CB  . GLN B 2 20  ? -40.91645 35.53640 13.60056  1.000 52.48472  ? 78  GLN B CB  1 
ATOM   1308 C CG  . GLN B 2 20  ? -39.63203 36.28041 13.49438  1.000 68.93747  ? 78  GLN B CG  1 
ATOM   1309 C CD  . GLN B 2 20  ? -39.27265 36.75682 12.06588  1.000 77.58083  ? 78  GLN B CD  1 
ATOM   1310 O OE1 . GLN B 2 20  ? -39.77786 36.25109 11.04470  1.000 55.45831  ? 78  GLN B OE1 1 
ATOM   1311 N NE2 . GLN B 2 20  ? -38.35824 37.72931 12.00834  1.000 69.84266  ? 78  GLN B NE2 1 
ATOM   1312 N N   . LEU B 2 21  ? -39.20304 34.48080 16.42589  1.000 75.23998  ? 79  LEU B N   1 
ATOM   1313 C CA  . LEU B 2 21  ? -38.04553 33.79812 17.00352  1.000 56.71186  ? 79  LEU B CA  1 
ATOM   1314 C C   . LEU B 2 21  ? -38.41514 32.77647 18.07787  1.000 56.81514  ? 79  LEU B C   1 
ATOM   1315 O O   . LEU B 2 21  ? -37.76876 31.72858 18.17902  1.000 66.38686  ? 79  LEU B O   1 
ATOM   1316 C CB  . LEU B 2 21  ? -37.07072 34.83050 17.58812  1.000 71.07829  ? 79  LEU B CB  1 
ATOM   1317 C CG  . LEU B 2 21  ? -35.59357 34.41048 17.74542  1.000 69.64028  ? 79  LEU B CG  1 
ATOM   1318 C CD1 . LEU B 2 21  ? -34.89257 34.51105 16.41047  1.000 75.73902  ? 79  LEU B CD1 1 
ATOM   1319 C CD2 . LEU B 2 21  ? -34.86966 35.26368 18.76683  1.000 53.28641  ? 79  LEU B CD2 1 
ATOM   1320 N N   . GLU B 2 22  ? -39.41919 33.05643 18.90904  1.000 67.14641  ? 80  GLU B N   1 
ATOM   1321 C CA  . GLU B 2 22  ? -39.88571 32.04385 19.85052  1.000 64.77224  ? 80  GLU B CA  1 
ATOM   1322 C C   . GLU B 2 22  ? -40.78552 31.02019 19.17234  1.000 66.23850  ? 80  GLU B C   1 
ATOM   1323 O O   . GLU B 2 22  ? -41.16712 30.02581 19.80308  1.000 78.19806  ? 80  GLU B O   1 
ATOM   1324 C CB  . GLU B 2 22  ? -40.67534 32.67222 20.98644  1.000 75.44533  ? 80  GLU B CB  1 
ATOM   1325 C CG  . GLU B 2 22  ? -41.38755 33.96361 20.57693  1.000 95.70118  ? 80  GLU B CG  1 
ATOM   1326 C CD  . GLU B 2 22  ? -42.33846 34.49348 21.64942  1.000 109.78792 ? 80  GLU B CD  1 
ATOM   1327 O OE1 . GLU B 2 22  ? -41.92353 34.47122 22.83075  1.000 107.53949 ? 80  GLU B OE1 1 
ATOM   1328 O OE2 . GLU B 2 22  ? -43.50795 34.87064 21.30701  1.000 87.24336  ? 80  GLU B OE2 1 
ATOM   1329 N N   . ALA B 2 23  ? -41.15116 31.25630 17.91306  1.000 60.44959  ? 81  ALA B N   1 
ATOM   1330 C CA  . ALA B 2 23  ? -41.89862 30.29363 17.14191  1.000 65.53483  ? 81  ALA B CA  1 
ATOM   1331 C C   . ALA B 2 23  ? -41.04870 29.06961 16.85456  1.000 63.55768  ? 81  ALA B C   1 
ATOM   1332 O O   . ALA B 2 23  ? -39.81850 29.14335 16.82814  1.000 61.33319  ? 81  ALA B O   1 
ATOM   1333 C CB  . ALA B 2 23  ? -42.37648 30.93004 15.84121  1.000 75.67755  ? 81  ALA B CB  1 
ATOM   1334 N N   . PRO B 2 24  ? -41.68941 27.92377 16.65263  1.000 76.73695  ? 82  PRO B N   1 
ATOM   1335 C CA  . PRO B 2 24  ? -40.94832 26.71952 16.27135  1.000 63.07671  ? 82  PRO B CA  1 
ATOM   1336 C C   . PRO B 2 24  ? -40.14958 26.94163 15.00340  1.000 49.26456  ? 82  PRO B C   1 
ATOM   1337 O O   . PRO B 2 24  ? -40.52503 27.70707 14.10920  1.000 47.09736  ? 82  PRO B O   1 
ATOM   1338 C CB  . PRO B 2 24  ? -42.03713 25.66035 16.05192  1.000 51.74520  ? 82  PRO B CB  1 
ATOM   1339 C CG  . PRO B 2 24  ? -43.27135 26.21710 16.56229  1.000 56.82848  ? 82  PRO B CG  1 
ATOM   1340 C CD  . PRO B 2 24  ? -43.10398 27.65366 16.91170  1.000 72.80269  ? 82  PRO B CD  1 
ATOM   1341 N N   . VAL B 2 25  ? -39.03067 26.23475 14.93714  1.000 45.44363  ? 83  VAL B N   1 
ATOM   1342 C CA  . VAL B 2 25  ? -38.13779 26.41107 13.81808  1.000 49.76238  ? 83  VAL B CA  1 
ATOM   1343 C C   . VAL B 2 25  ? -38.86914 26.12367 12.52428  1.000 47.57136  ? 83  VAL B C   1 
ATOM   1344 O O   . VAL B 2 25  ? -39.81124 25.32563 12.46774  1.000 42.35761  ? 83  VAL B O   1 
ATOM   1345 C CB  . VAL B 2 25  ? -36.90141 25.52864 13.99905  1.000 48.82852  ? 83  VAL B CB  1 
ATOM   1346 C CG1 . VAL B 2 25  ? -35.82254 25.99989 13.04656  1.000 57.72024  ? 83  VAL B CG1 1 
ATOM   1347 C CG2 . VAL B 2 25  ? -36.42195 25.68631 15.39776  1.000 55.07264  ? 83  VAL B CG2 1 
ATOM   1348 N N   . GLN B 2 26  ? -38.45621 26.83553 11.49477  1.000 53.72240  ? 84  GLN B N   1 
ATOM   1349 C CA  . GLN B 2 26  ? -38.99081 26.81104 10.15107  1.000 48.80729  ? 84  GLN B CA  1 
ATOM   1350 C C   . GLN B 2 26  ? -37.85498 26.46014 9.21075   1.000 57.94607  ? 84  GLN B C   1 
ATOM   1351 O O   . GLN B 2 26  ? -36.71984 26.23390 9.65004   1.000 56.83357  ? 84  GLN B O   1 
ATOM   1352 C CB  . GLN B 2 26  ? -39.61823 28.15708 9.79767   1.000 53.91756  ? 84  GLN B CB  1 
ATOM   1353 C CG  . GLN B 2 26  ? -40.12437 28.94497 11.00244  1.000 69.36971  ? 84  GLN B CG  1 
ATOM   1354 C CD  . GLN B 2 26  ? -40.58059 30.34966 10.60824  1.000 89.26663  ? 84  GLN B CD  1 
ATOM   1355 O OE1 . GLN B 2 26  ? -41.15917 30.52135 9.52731   1.000 98.75407  ? 84  GLN B OE1 1 
ATOM   1356 N NE2 . GLN B 2 26  ? -40.35346 31.35308 11.48081  1.000 67.50987  ? 84  GLN B NE2 1 
ATOM   1357 N N   . ASN B 2 27  ? -38.16478 26.43426 7.91016   1.000 50.38654  ? 85  ASN B N   1 
ATOM   1358 C CA  . ASN B 2 27  ? -37.22138 25.95645 6.89179   1.000 45.47969  ? 85  ASN B CA  1 
ATOM   1359 C C   . ASN B 2 27  ? -36.48338 24.70511 7.35871   1.000 58.26736  ? 85  ASN B C   1 
ATOM   1360 O O   . ASN B 2 27  ? -35.28329 24.52600 7.11009   1.000 57.18804  ? 85  ASN B O   1 
ATOM   1361 C CB  . ASN B 2 27  ? -36.24123 27.04716 6.49534   1.000 54.48994  ? 85  ASN B CB  1 
ATOM   1362 C CG  . ASN B 2 27  ? -35.42834 26.68131 5.26748   1.000 66.89446  ? 85  ASN B CG  1 
ATOM   1363 O OD1 . ASN B 2 27  ? -35.54664 25.56496 4.74921   1.000 67.50590  ? 85  ASN B OD1 1 
ATOM   1364 N ND2 . ASN B 2 27  ? -34.60033 27.60365 4.79924   1.000 63.01656  ? 85  ASN B ND2 1 
ATOM   1365 N N   . ALA B 2 28  ? -37.21449 23.82427 8.04817   1.000 49.54375  ? 86  ALA B N   1 
ATOM   1366 C CA  . ALA B 2 28  ? -36.62199 22.57974 8.50881   1.000 45.84461  ? 86  ALA B CA  1 
ATOM   1367 C C   . ALA B 2 28  ? -35.95232 21.81236 7.36576   1.000 51.29660  ? 86  ALA B C   1 
ATOM   1368 O O   . ALA B 2 28  ? -34.93657 21.12735 7.56530   1.000 48.79655  ? 86  ALA B O   1 
ATOM   1369 C CB  . ALA B 2 28  ? -37.71562 21.75307 9.17551   1.000 52.36390  ? 86  ALA B CB  1 
ATOM   1370 N N   . GLU B 2 29  ? -36.47179 21.96859 6.15022   1.000 58.05044  ? 87  GLU B N   1 
ATOM   1371 C CA  . GLU B 2 29  ? -35.95307 21.22551 5.00525   1.000 53.62882  ? 87  GLU B CA  1 
ATOM   1372 C C   . GLU B 2 29  ? -34.49391 21.56241 4.72430   1.000 61.61376  ? 87  GLU B C   1 
ATOM   1373 O O   . GLU B 2 29  ? -33.66301 20.65842 4.57828   1.000 61.92563  ? 87  GLU B O   1 
ATOM   1374 C CB  . GLU B 2 29  ? -36.84023 21.51399 3.79530   1.000 62.33525  ? 87  GLU B CB  1 
ATOM   1375 C CG  . GLU B 2 29  ? -38.24068 20.93868 3.96369   1.000 57.14629  ? 87  GLU B CG  1 
ATOM   1376 C CD  . GLU B 2 29  ? -39.17912 21.77268 4.84422   1.000 62.58465  ? 87  GLU B CD  1 
ATOM   1377 O OE1 . GLU B 2 29  ? -38.78864 22.87122 5.32845   1.000 46.21761  ? 87  GLU B OE1 1 
ATOM   1378 O OE2 . GLU B 2 29  ? -40.30103 21.26805 5.09864   1.000 73.30160  ? 87  GLU B OE2 1 
ATOM   1379 N N   . GLY B 2 30  ? -34.16214 22.85622 4.64594   1.000 54.65807  ? 88  GLY B N   1 
ATOM   1380 C CA  . GLY B 2 30  ? -32.77734 23.24756 4.41400   1.000 52.23306  ? 88  GLY B CA  1 
ATOM   1381 C C   . GLY B 2 30  ? -31.85637 22.81797 5.54042   1.000 51.41475  ? 88  GLY B C   1 
ATOM   1382 O O   . GLY B 2 30  ? -30.84173 22.16343 5.30636   1.000 52.37526  ? 88  GLY B O   1 
ATOM   1383 N N   . ARG B 2 31  ? -32.21571 23.15340 6.78230   1.000 48.29099  ? 89  ARG B N   1 
ATOM   1384 C CA  . ARG B 2 31  ? -31.45184 22.70489 7.94363   1.000 44.24590  ? 89  ARG B CA  1 
ATOM   1385 C C   . ARG B 2 31  ? -31.08847 21.23300 7.85625   1.000 57.17932  ? 89  ARG B C   1 
ATOM   1386 O O   . ARG B 2 31  ? -29.98535 20.83006 8.24456   1.000 67.69101  ? 89  ARG B O   1 
ATOM   1387 C CB  . ARG B 2 31  ? -32.22231 22.97109 9.22333   1.000 43.73510  ? 89  ARG B CB  1 
ATOM   1388 C CG  . ARG B 2 31  ? -32.57772 24.41922 9.41747   1.000 48.55187  ? 89  ARG B CG  1 
ATOM   1389 C CD  . ARG B 2 31  ? -33.45783 24.66928 10.64964  1.000 68.69000  ? 89  ARG B CD  1 
ATOM   1390 N NE  . ARG B 2 31  ? -32.82539 24.33152 11.92747  1.000 71.88460  ? 89  ARG B NE  1 
ATOM   1391 C CZ  . ARG B 2 31  ? -32.45431 25.22475 12.84070  1.000 68.07248  ? 89  ARG B CZ  1 
ATOM   1392 N NH1 . ARG B 2 31  ? -32.65354 26.52273 12.66199  1.000 55.65044  ? 89  ARG B NH1 1 
ATOM   1393 N NH2 . ARG B 2 31  ? -31.88390 24.80240 13.96356  1.000 54.05946  ? 89  ARG B NH2 1 
ATOM   1394 N N   . GLU B 2 32  ? -31.99805 20.39972 7.36857   1.000 56.75111  ? 90  GLU B N   1 
ATOM   1395 C CA  . GLU B 2 32  ? -31.59495 19.02451 7.13215   1.000 48.39201  ? 90  GLU B CA  1 
ATOM   1396 C C   . GLU B 2 32  ? -30.55919 18.94095 6.04702   1.000 53.78704  ? 90  GLU B C   1 
ATOM   1397 O O   . GLU B 2 32  ? -29.61346 18.15692 6.14343   1.000 59.11290  ? 90  GLU B O   1 
ATOM   1398 C CB  . GLU B 2 32  ? -32.78529 18.18767 6.75544   1.000 70.49791  ? 90  GLU B CB  1 
ATOM   1399 C CG  . GLU B 2 32  ? -33.29536 17.47462 7.91052   1.000 84.35596  ? 90  GLU B CG  1 
ATOM   1400 C CD  . GLU B 2 32  ? -34.17241 16.38121 7.45640   1.000 93.65371  ? 90  GLU B CD  1 
ATOM   1401 O OE1 . GLU B 2 32  ? -35.18605 16.12437 8.15190   1.000 88.09003  ? 90  GLU B OE1 1 
ATOM   1402 O OE2 . GLU B 2 32  ? -33.86159 15.82873 6.37108   1.000 83.85645  ? 90  GLU B OE2 1 
ATOM   1403 N N   . ARG B 2 33  ? -30.75117 19.70511 4.97832   1.000 52.25410  ? 91  ARG B N   1 
ATOM   1404 C CA  . ARG B 2 33  ? -29.77621 19.69790 3.90611   1.000 53.35050  ? 91  ARG B CA  1 
ATOM   1405 C C   . ARG B 2 33  ? -28.43668 20.19533 4.41269   1.000 61.69207  ? 91  ARG B C   1 
ATOM   1406 O O   . ARG B 2 33  ? -27.40357 19.55766 4.17897   1.000 71.83536  ? 91  ARG B O   1 
ATOM   1407 C CB  . ARG B 2 33  ? -30.27702 20.54046 2.74576   1.000 61.67386  ? 91  ARG B CB  1 
ATOM   1408 C CG  . ARG B 2 33  ? -29.49809 20.31924 1.49428   1.000 63.58782  ? 91  ARG B CG  1 
ATOM   1409 C CD  . ARG B 2 33  ? -30.41988 20.25145 0.30701   1.000 68.34077  ? 91  ARG B CD  1 
ATOM   1410 N NE  . ARG B 2 33  ? -31.38980 21.33719 0.32006   1.000 75.14773  ? 91  ARG B NE  1 
ATOM   1411 C CZ  . ARG B 2 33  ? -32.69828 21.18052 0.16780   1.000 84.62281  ? 91  ARG B CZ  1 
ATOM   1412 N NH1 . ARG B 2 33  ? -33.22929 19.98484 -0.04449  1.000 90.67456  ? 91  ARG B NH1 1 
ATOM   1413 N NH2 . ARG B 2 33  ? -33.49276 22.25070 0.22802   1.000 65.49389  ? 91  ARG B NH2 1 
ATOM   1414 N N   . LEU B 2 34  ? -28.42877 21.30598 5.15381   1.000 60.71885  ? 92  LEU B N   1 
ATOM   1415 C CA  . LEU B 2 34  ? -27.15963 21.79909 5.69167   1.000 65.17256  ? 92  LEU B CA  1 
ATOM   1416 C C   . LEU B 2 34  ? -26.55194 20.81319 6.67705   1.000 59.39117  ? 92  LEU B C   1 
ATOM   1417 O O   . LEU B 2 34  ? -25.34422 20.54877 6.63836   1.000 58.31149  ? 92  LEU B O   1 
ATOM   1418 C CB  . LEU B 2 34  ? -27.32966 23.17472 6.33239   1.000 58.65610  ? 92  LEU B CB  1 
ATOM   1419 C CG  . LEU B 2 34  ? -25.98955 23.85021 6.65824   1.000 56.76081  ? 92  LEU B CG  1 
ATOM   1420 C CD1 . LEU B 2 34  ? -25.51772 23.49510 8.05010   1.000 75.39342  ? 92  LEU B CD1 1 
ATOM   1421 C CD2 . LEU B 2 34  ? -24.91433 23.44358 5.65394   1.000 50.73023  ? 92  LEU B CD2 1 
ATOM   1422 N N   . MET B 2 35  ? -27.37334 20.25948 7.56752   1.000 72.47296  ? 93  MET B N   1 
ATOM   1423 C CA  . MET B 2 35  ? -26.86358 19.33020 8.57003   1.000 61.80324  ? 93  MET B CA  1 
ATOM   1424 C C   . MET B 2 35  ? -26.34962 18.05524 7.93825   1.000 69.92202  ? 93  MET B C   1 
ATOM   1425 O O   . MET B 2 35  ? -25.65310 17.28132 8.60586   1.000 75.12178  ? 93  MET B O   1 
ATOM   1426 C CB  . MET B 2 35  ? -27.95987 19.03245 9.59156   1.000 66.22901  ? 93  MET B CB  1 
ATOM   1427 C CG  . MET B 2 35  ? -28.05071 20.07725 10.70480  1.000 75.35480  ? 93  MET B CG  1 
ATOM   1428 S SD  . MET B 2 35  ? -26.41928 20.66621 11.22809  1.000 83.09963  ? 93  MET B SD  1 
ATOM   1429 C CE  . MET B 2 35  ? -26.63074 22.44413 11.18470  1.000 79.14242  ? 93  MET B CE  1 
ATOM   1430 N N   . ALA B 2 36  ? -26.67183 17.82789 6.66222   1.000 70.67464  ? 94  ALA B N   1 
ATOM   1431 C CA  . ALA B 2 36  ? -26.19006 16.65809 5.93852   1.000 64.28279  ? 94  ALA B CA  1 
ATOM   1432 C C   . ALA B 2 36  ? -24.86327 16.91451 5.23633   1.000 90.92118  ? 94  ALA B C   1 
ATOM   1433 O O   . ALA B 2 36  ? -24.04051 15.99582 5.14215   1.000 90.96737  ? 94  ALA B O   1 
ATOM   1434 C CB  . ALA B 2 36  ? -27.23826 16.20074 4.91717   1.000 59.93903  ? 94  ALA B CB  1 
ATOM   1435 N N   . VAL B 2 37  ? -24.64259 18.13192 4.72883   1.000 76.85991  ? 95  VAL B N   1 
ATOM   1436 C CA  . VAL B 2 37  ? -23.34466 18.49431 4.18341   1.000 61.31193  ? 95  VAL B CA  1 
ATOM   1437 C C   . VAL B 2 37  ? -22.29858 18.02513 5.18566   1.000 71.74244  ? 95  VAL B C   1 
ATOM   1438 O O   . VAL B 2 37  ? -22.06875 18.68689 6.20392   1.000 91.14376  ? 95  VAL B O   1 
ATOM   1439 C CB  . VAL B 2 37  ? -23.23703 20.01184 3.93374   1.000 65.65546  ? 95  VAL B CB  1 
ATOM   1440 C CG1 . VAL B 2 37  ? -21.82928 20.39122 3.50104   1.000 60.40811  ? 95  VAL B CG1 1 
ATOM   1441 C CG2 . VAL B 2 37  ? -24.30649 20.48769 2.95187   1.000 61.51459  ? 95  VAL B CG2 1 
ATOM   1442 N N   . LYS B 2 38  ? -21.74001 16.82776 4.96094   1.000 72.34685  ? 96  LYS B N   1 
ATOM   1443 C CA  . LYS B 2 38  ? -20.55968 16.36131 5.67994   1.000 75.51913  ? 96  LYS B CA  1 
ATOM   1444 C C   . LYS B 2 38  ? -19.34841 16.74130 4.84937   1.000 72.86500  ? 96  LYS B C   1 
ATOM   1445 O O   . LYS B 2 38  ? -19.11564 16.13784 3.79033   1.000 82.39490  ? 96  LYS B O   1 
ATOM   1446 C CB  . LYS B 2 38  ? -20.59311 14.84694 5.89952   1.000 71.86005  ? 96  LYS B CB  1 
ATOM   1447 N N   . PRO B 2 39  ? -18.57331 17.74255 5.25053   1.000 82.64809  ? 97  PRO B N   1 
ATOM   1448 C CA  . PRO B 2 39  ? -17.38157 18.12353 4.48305   1.000 82.45189  ? 97  PRO B CA  1 
ATOM   1449 C C   . PRO B 2 39  ? -16.20535 17.19078 4.74814   1.000 82.98085  ? 97  PRO B C   1 
ATOM   1450 O O   . PRO B 2 39  ? -16.14086 16.50373 5.76636   1.000 92.71947  ? 97  PRO B O   1 
ATOM   1451 C CB  . PRO B 2 39  ? -17.08800 19.55100 4.97584   1.000 88.82680  ? 97  PRO B CB  1 
ATOM   1452 C CG  . PRO B 2 39  ? -18.09637 19.83663 6.09199   1.000 77.38527  ? 97  PRO B CG  1 
ATOM   1453 C CD  . PRO B 2 39  ? -18.75580 18.56269 6.45832   1.000 70.49973  ? 97  PRO B CD  1 
ATOM   1454 N N   . GLU B 2 40  ? -15.26527 17.17099 3.80016   1.000 97.91767  ? 98  GLU B N   1 
ATOM   1455 C CA  . GLU B 2 40  ? -14.03441 16.36563 3.89264   1.000 99.79138  ? 98  GLU B CA  1 
ATOM   1456 C C   . GLU B 2 40  ? -12.84158 17.32051 3.96570   1.000 103.51487 ? 98  GLU B C   1 
ATOM   1457 O O   . GLU B 2 40  ? -12.21062 17.63296 2.95366   1.000 109.31455 ? 98  GLU B O   1 
ATOM   1458 C CB  . GLU B 2 40  ? -13.89633 15.37367 2.68367   1.000 74.61934  ? 98  GLU B CB  1 
ATOM   1459 N N   . TRP B 2 41  ? -12.53683 17.79425 5.16862   1.000 100.17996 ? 99  TRP B N   1 
ATOM   1460 C CA  . TRP B 2 41  ? -11.41609 18.70538 5.33638   1.000 93.58031  ? 99  TRP B CA  1 
ATOM   1461 C C   . TRP B 2 41  ? -10.10414 17.93615 5.50209   1.000 105.28969 ? 99  TRP B C   1 
ATOM   1462 O O   . TRP B 2 41  ? -10.08117 16.77431 5.91843   1.000 101.89507 ? 99  TRP B O   1 
ATOM   1463 C CB  . TRP B 2 41  ? -11.64478 19.60310 6.54867   1.000 89.44227  ? 99  TRP B CB  1 
ATOM   1464 C CG  . TRP B 2 41  ? -12.92774 20.38894 6.53841   1.000 88.65617  ? 99  TRP B CG  1 
ATOM   1465 C CD1 . TRP B 2 41  ? -14.00210 20.20719 7.35841   1.000 78.53825  ? 99  TRP B CD1 1 
ATOM   1466 C CD2 . TRP B 2 41  ? -13.25617 21.49392 5.68978   1.000 78.67639  ? 99  TRP B CD2 1 
ATOM   1467 N NE1 . TRP B 2 41  ? -14.98028 21.11471 7.06276   1.000 80.11214  ? 99  TRP B NE1 1 
ATOM   1468 C CE2 . TRP B 2 41  ? -14.54424 21.92183 6.04497   1.000 72.71588  ? 99  TRP B CE2 1 
ATOM   1469 C CE3 . TRP B 2 41  ? -12.58967 22.15532 4.66112   1.000 78.88438  ? 99  TRP B CE3 1 
ATOM   1470 C CZ2 . TRP B 2 41  ? -15.17444 22.98417 5.41434   1.000 73.35183  ? 99  TRP B CZ2 1 
ATOM   1471 C CZ3 . TRP B 2 41  ? -13.22172 23.20114 4.03052   1.000 82.15719  ? 99  TRP B CZ3 1 
ATOM   1472 C CH2 . TRP B 2 41  ? -14.49467 23.61348 4.41427   1.000 76.82151  ? 99  TRP B CH2 1 
ATOM   1473 N N   . LYS B 2 42  ? -8.99791  18.60170 5.18827   1.000 93.91192  ? 100 LYS B N   1 
ATOM   1474 C CA  . LYS B 2 42  ? -7.70723  17.94836 5.36280   1.000 78.72462  ? 100 LYS B CA  1 
ATOM   1475 C C   . LYS B 2 42  ? -6.76690  18.76083 6.23792   1.000 81.10162  ? 100 LYS B C   1 
ATOM   1476 O O   . LYS B 2 42  ? -5.78479  18.23412 6.75147   1.000 76.40709  ? 100 LYS B O   1 
ATOM   1477 C CB  . LYS B 2 42  ? -7.06192  17.67533 4.00976   1.000 76.70711  ? 100 LYS B CB  1 
HETATM 1478 P P   . PO4 C 3 .   ? -16.52191 45.31970 9.12503   1.000 123.44643 ? 201 PO4 A P   1 
HETATM 1479 O O1  . PO4 C 3 .   ? -16.17600 45.51102 7.66030   1.000 106.92215 ? 201 PO4 A O1  1 
HETATM 1480 O O2  . PO4 C 3 .   ? -18.02618 45.19175 9.25455   1.000 95.18359  ? 201 PO4 A O2  1 
HETATM 1481 O O3  . PO4 C 3 .   ? -15.80693 44.07749 9.64110   1.000 107.56549 ? 201 PO4 A O3  1 
HETATM 1482 O O4  . PO4 C 3 .   ? -16.06028 46.51174 9.94817   1.000 133.36318 ? 201 PO4 A O4  1 
HETATM 1483 O O   . HOH D 4 .   ? -28.84011 23.33161 13.57588  1.000 56.79346  ? 301 HOH A O   1 
HETATM 1484 O O   . HOH D 4 .   ? -16.41589 23.34387 13.93169  1.000 54.78313  ? 302 HOH A O   1 
# 
