data_9IAC
# 
_entry.id   9IAC 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   9IAC         pdb_00009iac 10.2210/pdb9iac/pdb 
WWPDB D_1292145387 ?            ?                   
# 
loop_
_pdbx_audit_revision_history.ordinal 
_pdbx_audit_revision_history.data_content_type 
_pdbx_audit_revision_history.major_revision 
_pdbx_audit_revision_history.minor_revision 
_pdbx_audit_revision_history.revision_date 
_pdbx_audit_revision_history.part_number 
1 'Structure model' 1 0 2025-04-23 ? 
2 'Structure model' 1 1 2025-05-07 ? 
3 'Structure model' 1 2 2025-05-28 ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
loop_
_pdbx_audit_revision_group.ordinal 
_pdbx_audit_revision_group.revision_ordinal 
_pdbx_audit_revision_group.data_content_type 
_pdbx_audit_revision_group.group 
1 2 'Structure model' 'Database references' 
2 3 'Structure model' 'Database references' 
# 
loop_
_pdbx_audit_revision_category.ordinal 
_pdbx_audit_revision_category.revision_ordinal 
_pdbx_audit_revision_category.data_content_type 
_pdbx_audit_revision_category.category 
1 2 'Structure model' citation        
2 2 'Structure model' citation_author 
3 3 'Structure model' citation        
# 
loop_
_pdbx_audit_revision_item.ordinal 
_pdbx_audit_revision_item.revision_ordinal 
_pdbx_audit_revision_item.data_content_type 
_pdbx_audit_revision_item.item 
1  2 'Structure model' '_citation.country'                 
2  2 'Structure model' '_citation.journal_abbrev'          
3  2 'Structure model' '_citation.journal_id_ASTM'         
4  2 'Structure model' '_citation.journal_id_CSD'          
5  2 'Structure model' '_citation.journal_id_ISSN'         
6  2 'Structure model' '_citation.pdbx_database_id_DOI'    
7  2 'Structure model' '_citation.pdbx_database_id_PubMed' 
8  2 'Structure model' '_citation.title'                   
9  2 'Structure model' '_citation.year'                    
10 2 'Structure model' '_citation_author.identifier_ORCID' 
11 3 'Structure model' '_citation.journal_volume'          
12 3 'Structure model' '_citation.page_first'              
# 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.entry_id                        9IAC 
_pdbx_database_status.recvd_initial_deposition_date   2025-02-09 
_pdbx_database_status.SG_entry                        N 
_pdbx_database_status.deposit_site                    PDBE 
_pdbx_database_status.process_site                    PDBE 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.methods_development_category    ? 
_pdbx_database_status.pdb_format_compatible           Y 
# 
_pdbx_database_related.db_name        PDB 
_pdbx_database_related.details        'Structure of protein homolog determined in same study' 
_pdbx_database_related.db_id          9IAB 
_pdbx_database_related.content_type   unspecified 
# 
_pdbx_contact_author.id                 2 
_pdbx_contact_author.email              daan.swarts@wur.nl 
_pdbx_contact_author.name_first         Daan 
_pdbx_contact_author.name_last          Swarts 
_pdbx_contact_author.name_mi            C. 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0003-4412-9191 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Bobadilla Ugarte, P.' 1 0000-0003-4147-167X 
'Halter, S.'           2 ?                   
'Jinek, M.'            3 0000-0002-7601-210X 
'Swarts, D.C.'         4 0000-0003-4412-9191 
# 
_citation.abstract                  ? 
_citation.abstract_id_CAS           ? 
_citation.book_id_ISBN              ? 
_citation.book_publisher            ? 
_citation.book_publisher_city       ? 
_citation.book_title                ? 
_citation.coordinate_linkage        ? 
_citation.country                   US 
_citation.database_id_Medline       ? 
_citation.details                   ? 
_citation.id                        primary 
_citation.journal_abbrev            Mol.Cell 
_citation.journal_id_ASTM           MOCEFL 
_citation.journal_id_CSD            2168 
_citation.journal_id_ISSN           1097-2765 
_citation.journal_full              ? 
_citation.journal_issue             ? 
_citation.journal_volume            85 
_citation.language                  ? 
_citation.page_first                1920 
_citation.page_last                 ? 
_citation.title                     'Cyanobacterial Argonautes and Cas4 family nucleases cooperate to interfere with invading DNA.' 
_citation.year                      2025 
_citation.database_id_CSD           ? 
_citation.pdbx_database_id_DOI      10.1016/j.molcel.2025.03.025 
_citation.pdbx_database_id_PubMed   40288374 
_citation.pdbx_database_id_patent   ? 
_citation.unpublished_flag          ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.ordinal 
_citation_author.identifier_ORCID 
primary 'Bobadilla Ugarte, P.' 1  ? 
primary 'Halter, S.'           2  ? 
primary 'Mutte, S.K.'          3  ? 
primary 'Heijstek, C.'         4  ? 
primary 'Niault, T.'           5  ? 
primary 'Terenin, I.'          6  ? 
primary 'Barendse, P.'         7  ? 
primary 'Koopal, B.'           8  ? 
primary 'Roosjen, M.'          9  ? 
primary 'Boeren, S.'           10 ? 
primary 'Hauryliuk, V.'        11 ? 
primary 'Jinek, M.'            12 ? 
primary 'Westphal, A.H.'       13 ? 
primary 'Swarts, D.C.'         14 ? 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'Similar to tr|Q3MCC8|Q3MCC8_ANAVT Hypothetical protein' 32064.199 2  ? ? ? 
'Expression constructed contained His-MBP-TEV site, hence altered amino acids on positions 1-2.' 
2 non-polymer syn 'IRON/SULFUR CLUSTER'                                    351.640   2  ? ? ? ? 
3 non-polymer syn 'MAGNESIUM ION'                                          24.305    2  ? ? ? ? 
4 non-polymer syn 1,2-ETHANEDIOL                                           62.068    6  ? ? ? ? 
5 water       nat water                                                    18.015    50 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;SASCQSPKKPWYPPMSYSLWRSLKPAIGYENWHCQTKRGFEKARNKEPEVQRLLSEDNQPQKIGKLAQRGVFEFHQELVR
LSGSHGVEQVAEILQLNQESPEIQARVLVILNNYYQQPILLNKEIINLSRGDEGYPEPIVIEQGNYKFNLSAAFDCIFRE
ADDTIHILDLKTGQSNFDRRQAHVYLLAASYRYPQEKIVASFYNLETQTSSEKISLSSEAIEAVKIELASLAKKHQQQLQ
KYKDHPKDFYHIFPPQSGYVCRYCPFTSICDYANKEV
;
_entity_poly.pdbx_seq_one_letter_code_can   
;SASCQSPKKPWYPPMSYSLWRSLKPAIGYENWHCQTKRGFEKARNKEPEVQRLLSEDNQPQKIGKLAQRGVFEFHQELVR
LSGSHGVEQVAEILQLNQESPEIQARVLVILNNYYQQPILLNKEIINLSRGDEGYPEPIVIEQGNYKFNLSAAFDCIFRE
ADDTIHILDLKTGQSNFDRRQAHVYLLAASYRYPQEKIVASFYNLETQTSSEKISLSSEAIEAVKIELASLAKKHQQQLQ
KYKDHPKDFYHIFPPQSGYVCRYCPFTSICDYANKEV
;
_entity_poly.pdbx_strand_id                 A,B 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'IRON/SULFUR CLUSTER' SF4 
3 'MAGNESIUM ION'       MG  
4 1,2-ETHANEDIOL        EDO 
5 water                 HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   SER n 
1 2   ALA n 
1 3   SER n 
1 4   CYS n 
1 5   GLN n 
1 6   SER n 
1 7   PRO n 
1 8   LYS n 
1 9   LYS n 
1 10  PRO n 
1 11  TRP n 
1 12  TYR n 
1 13  PRO n 
1 14  PRO n 
1 15  MET n 
1 16  SER n 
1 17  TYR n 
1 18  SER n 
1 19  LEU n 
1 20  TRP n 
1 21  ARG n 
1 22  SER n 
1 23  LEU n 
1 24  LYS n 
1 25  PRO n 
1 26  ALA n 
1 27  ILE n 
1 28  GLY n 
1 29  TYR n 
1 30  GLU n 
1 31  ASN n 
1 32  TRP n 
1 33  HIS n 
1 34  CYS n 
1 35  GLN n 
1 36  THR n 
1 37  LYS n 
1 38  ARG n 
1 39  GLY n 
1 40  PHE n 
1 41  GLU n 
1 42  LYS n 
1 43  ALA n 
1 44  ARG n 
1 45  ASN n 
1 46  LYS n 
1 47  GLU n 
1 48  PRO n 
1 49  GLU n 
1 50  VAL n 
1 51  GLN n 
1 52  ARG n 
1 53  LEU n 
1 54  LEU n 
1 55  SER n 
1 56  GLU n 
1 57  ASP n 
1 58  ASN n 
1 59  GLN n 
1 60  PRO n 
1 61  GLN n 
1 62  LYS n 
1 63  ILE n 
1 64  GLY n 
1 65  LYS n 
1 66  LEU n 
1 67  ALA n 
1 68  GLN n 
1 69  ARG n 
1 70  GLY n 
1 71  VAL n 
1 72  PHE n 
1 73  GLU n 
1 74  PHE n 
1 75  HIS n 
1 76  GLN n 
1 77  GLU n 
1 78  LEU n 
1 79  VAL n 
1 80  ARG n 
1 81  LEU n 
1 82  SER n 
1 83  GLY n 
1 84  SER n 
1 85  HIS n 
1 86  GLY n 
1 87  VAL n 
1 88  GLU n 
1 89  GLN n 
1 90  VAL n 
1 91  ALA n 
1 92  GLU n 
1 93  ILE n 
1 94  LEU n 
1 95  GLN n 
1 96  LEU n 
1 97  ASN n 
1 98  GLN n 
1 99  GLU n 
1 100 SER n 
1 101 PRO n 
1 102 GLU n 
1 103 ILE n 
1 104 GLN n 
1 105 ALA n 
1 106 ARG n 
1 107 VAL n 
1 108 LEU n 
1 109 VAL n 
1 110 ILE n 
1 111 LEU n 
1 112 ASN n 
1 113 ASN n 
1 114 TYR n 
1 115 TYR n 
1 116 GLN n 
1 117 GLN n 
1 118 PRO n 
1 119 ILE n 
1 120 LEU n 
1 121 LEU n 
1 122 ASN n 
1 123 LYS n 
1 124 GLU n 
1 125 ILE n 
1 126 ILE n 
1 127 ASN n 
1 128 LEU n 
1 129 SER n 
1 130 ARG n 
1 131 GLY n 
1 132 ASP n 
1 133 GLU n 
1 134 GLY n 
1 135 TYR n 
1 136 PRO n 
1 137 GLU n 
1 138 PRO n 
1 139 ILE n 
1 140 VAL n 
1 141 ILE n 
1 142 GLU n 
1 143 GLN n 
1 144 GLY n 
1 145 ASN n 
1 146 TYR n 
1 147 LYS n 
1 148 PHE n 
1 149 ASN n 
1 150 LEU n 
1 151 SER n 
1 152 ALA n 
1 153 ALA n 
1 154 PHE n 
1 155 ASP n 
1 156 CYS n 
1 157 ILE n 
1 158 PHE n 
1 159 ARG n 
1 160 GLU n 
1 161 ALA n 
1 162 ASP n 
1 163 ASP n 
1 164 THR n 
1 165 ILE n 
1 166 HIS n 
1 167 ILE n 
1 168 LEU n 
1 169 ASP n 
1 170 LEU n 
1 171 LYS n 
1 172 THR n 
1 173 GLY n 
1 174 GLN n 
1 175 SER n 
1 176 ASN n 
1 177 PHE n 
1 178 ASP n 
1 179 ARG n 
1 180 ARG n 
1 181 GLN n 
1 182 ALA n 
1 183 HIS n 
1 184 VAL n 
1 185 TYR n 
1 186 LEU n 
1 187 LEU n 
1 188 ALA n 
1 189 ALA n 
1 190 SER n 
1 191 TYR n 
1 192 ARG n 
1 193 TYR n 
1 194 PRO n 
1 195 GLN n 
1 196 GLU n 
1 197 LYS n 
1 198 ILE n 
1 199 VAL n 
1 200 ALA n 
1 201 SER n 
1 202 PHE n 
1 203 TYR n 
1 204 ASN n 
1 205 LEU n 
1 206 GLU n 
1 207 THR n 
1 208 GLN n 
1 209 THR n 
1 210 SER n 
1 211 SER n 
1 212 GLU n 
1 213 LYS n 
1 214 ILE n 
1 215 SER n 
1 216 LEU n 
1 217 SER n 
1 218 SER n 
1 219 GLU n 
1 220 ALA n 
1 221 ILE n 
1 222 GLU n 
1 223 ALA n 
1 224 VAL n 
1 225 LYS n 
1 226 ILE n 
1 227 GLU n 
1 228 LEU n 
1 229 ALA n 
1 230 SER n 
1 231 LEU n 
1 232 ALA n 
1 233 LYS n 
1 234 LYS n 
1 235 HIS n 
1 236 GLN n 
1 237 GLN n 
1 238 GLN n 
1 239 LEU n 
1 240 GLN n 
1 241 LYS n 
1 242 TYR n 
1 243 LYS n 
1 244 ASP n 
1 245 HIS n 
1 246 PRO n 
1 247 LYS n 
1 248 ASP n 
1 249 PHE n 
1 250 TYR n 
1 251 HIS n 
1 252 ILE n 
1 253 PHE n 
1 254 PRO n 
1 255 PRO n 
1 256 GLN n 
1 257 SER n 
1 258 GLY n 
1 259 TYR n 
1 260 VAL n 
1 261 CYS n 
1 262 ARG n 
1 263 TYR n 
1 264 CYS n 
1 265 PRO n 
1 266 PHE n 
1 267 THR n 
1 268 SER n 
1 269 ILE n 
1 270 CYS n 
1 271 ASP n 
1 272 TYR n 
1 273 ALA n 
1 274 ASN n 
1 275 LYS n 
1 276 GLU n 
1 277 VAL n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   277 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 IPF_560 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'Microcystis aeruginosa' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     1126 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE               ?                 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE              ?                 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE            ?                 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'       ?                 'C4 H7 N O4'     133.103 
CYS 'L-peptide linking' y CYSTEINE              ?                 'C3 H7 N O2 S'   121.158 
EDO non-polymer         . 1,2-ETHANEDIOL        'ETHYLENE GLYCOL' 'C2 H6 O2'       62.068  
GLN 'L-peptide linking' y GLUTAMINE             ?                 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'       ?                 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE               ?                 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE             ?                 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                 ?                 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE            ?                 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE               ?                 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                ?                 'C6 H15 N2 O2 1' 147.195 
MET 'L-peptide linking' y METHIONINE            ?                 'C5 H11 N O2 S'  149.211 
MG  non-polymer         . 'MAGNESIUM ION'       ?                 'Mg 2'           24.305  
PHE 'L-peptide linking' y PHENYLALANINE         ?                 'C9 H11 N O2'    165.189 
PRO 'L-peptide linking' y PROLINE               ?                 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                ?                 'C3 H7 N O3'     105.093 
SF4 non-polymer         . 'IRON/SULFUR CLUSTER' ?                 'Fe4 S4'         351.640 
THR 'L-peptide linking' y THREONINE             ?                 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN            ?                 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE              ?                 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                ?                 'C5 H11 N O2'    117.146 
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   SER 1   0   ?   ?   ?   A . n 
A 1 2   ALA 2   1   ?   ?   ?   A . n 
A 1 3   SER 3   2   ?   ?   ?   A . n 
A 1 4   CYS 4   3   ?   ?   ?   A . n 
A 1 5   GLN 5   4   ?   ?   ?   A . n 
A 1 6   SER 6   5   ?   ?   ?   A . n 
A 1 7   PRO 7   6   ?   ?   ?   A . n 
A 1 8   LYS 8   7   ?   ?   ?   A . n 
A 1 9   LYS 9   8   8   LYS LYS A . n 
A 1 10  PRO 10  9   9   PRO PRO A . n 
A 1 11  TRP 11  10  10  TRP TRP A . n 
A 1 12  TYR 12  11  11  TYR TYR A . n 
A 1 13  PRO 13  12  12  PRO PRO A . n 
A 1 14  PRO 14  13  13  PRO PRO A . n 
A 1 15  MET 15  14  14  MET MET A . n 
A 1 16  SER 16  15  15  SER SER A . n 
A 1 17  TYR 17  16  16  TYR TYR A . n 
A 1 18  SER 18  17  17  SER SER A . n 
A 1 19  LEU 19  18  18  LEU LEU A . n 
A 1 20  TRP 20  19  19  TRP TRP A . n 
A 1 21  ARG 21  20  20  ARG ARG A . n 
A 1 22  SER 22  21  21  SER SER A . n 
A 1 23  LEU 23  22  22  LEU LEU A . n 
A 1 24  LYS 24  23  23  LYS LYS A . n 
A 1 25  PRO 25  24  24  PRO PRO A . n 
A 1 26  ALA 26  25  25  ALA ALA A . n 
A 1 27  ILE 27  26  26  ILE ILE A . n 
A 1 28  GLY 28  27  27  GLY GLY A . n 
A 1 29  TYR 29  28  28  TYR TYR A . n 
A 1 30  GLU 30  29  29  GLU GLU A . n 
A 1 31  ASN 31  30  30  ASN ASN A . n 
A 1 32  TRP 32  31  31  TRP TRP A . n 
A 1 33  HIS 33  32  32  HIS HIS A . n 
A 1 34  CYS 34  33  33  CYS CYS A . n 
A 1 35  GLN 35  34  34  GLN GLN A . n 
A 1 36  THR 36  35  35  THR THR A . n 
A 1 37  LYS 37  36  36  LYS LYS A . n 
A 1 38  ARG 38  37  37  ARG ARG A . n 
A 1 39  GLY 39  38  38  GLY GLY A . n 
A 1 40  PHE 40  39  39  PHE PHE A . n 
A 1 41  GLU 41  40  40  GLU GLU A . n 
A 1 42  LYS 42  41  41  LYS LYS A . n 
A 1 43  ALA 43  42  42  ALA ALA A . n 
A 1 44  ARG 44  43  43  ARG ARG A . n 
A 1 45  ASN 45  44  44  ASN ASN A . n 
A 1 46  LYS 46  45  45  LYS LYS A . n 
A 1 47  GLU 47  46  46  GLU GLU A . n 
A 1 48  PRO 48  47  47  PRO PRO A . n 
A 1 49  GLU 49  48  48  GLU GLU A . n 
A 1 50  VAL 50  49  49  VAL VAL A . n 
A 1 51  GLN 51  50  50  GLN GLN A . n 
A 1 52  ARG 52  51  51  ARG ARG A . n 
A 1 53  LEU 53  52  52  LEU LEU A . n 
A 1 54  LEU 54  53  53  LEU LEU A . n 
A 1 55  SER 55  54  54  SER SER A . n 
A 1 56  GLU 56  55  55  GLU GLU A . n 
A 1 57  ASP 57  56  56  ASP ASP A . n 
A 1 58  ASN 58  57  57  ASN ASN A . n 
A 1 59  GLN 59  58  58  GLN GLN A . n 
A 1 60  PRO 60  59  59  PRO PRO A . n 
A 1 61  GLN 61  60  60  GLN GLN A . n 
A 1 62  LYS 62  61  61  LYS LYS A . n 
A 1 63  ILE 63  62  62  ILE ILE A . n 
A 1 64  GLY 64  63  63  GLY GLY A . n 
A 1 65  LYS 65  64  64  LYS LYS A . n 
A 1 66  LEU 66  65  65  LEU LEU A . n 
A 1 67  ALA 67  66  66  ALA ALA A . n 
A 1 68  GLN 68  67  67  GLN GLN A . n 
A 1 69  ARG 69  68  68  ARG ARG A . n 
A 1 70  GLY 70  69  69  GLY GLY A . n 
A 1 71  VAL 71  70  70  VAL VAL A . n 
A 1 72  PHE 72  71  71  PHE PHE A . n 
A 1 73  GLU 73  72  72  GLU GLU A . n 
A 1 74  PHE 74  73  73  PHE PHE A . n 
A 1 75  HIS 75  74  74  HIS HIS A . n 
A 1 76  GLN 76  75  75  GLN GLN A . n 
A 1 77  GLU 77  76  76  GLU GLU A . n 
A 1 78  LEU 78  77  77  LEU LEU A . n 
A 1 79  VAL 79  78  78  VAL VAL A . n 
A 1 80  ARG 80  79  79  ARG ARG A . n 
A 1 81  LEU 81  80  80  LEU LEU A . n 
A 1 82  SER 82  81  81  SER SER A . n 
A 1 83  GLY 83  82  82  GLY GLY A . n 
A 1 84  SER 84  83  83  SER SER A . n 
A 1 85  HIS 85  84  84  HIS HIS A . n 
A 1 86  GLY 86  85  85  GLY GLY A . n 
A 1 87  VAL 87  86  86  VAL VAL A . n 
A 1 88  GLU 88  87  87  GLU GLU A . n 
A 1 89  GLN 89  88  88  GLN GLN A . n 
A 1 90  VAL 90  89  89  VAL VAL A . n 
A 1 91  ALA 91  90  90  ALA ALA A . n 
A 1 92  GLU 92  91  91  GLU GLU A . n 
A 1 93  ILE 93  92  92  ILE ILE A . n 
A 1 94  LEU 94  93  93  LEU LEU A . n 
A 1 95  GLN 95  94  94  GLN GLN A . n 
A 1 96  LEU 96  95  95  LEU LEU A . n 
A 1 97  ASN 97  96  96  ASN ASN A . n 
A 1 98  GLN 98  97  97  GLN GLN A . n 
A 1 99  GLU 99  98  98  GLU GLU A . n 
A 1 100 SER 100 99  99  SER SER A . n 
A 1 101 PRO 101 100 100 PRO PRO A . n 
A 1 102 GLU 102 101 101 GLU GLU A . n 
A 1 103 ILE 103 102 102 ILE ILE A . n 
A 1 104 GLN 104 103 103 GLN GLN A . n 
A 1 105 ALA 105 104 104 ALA ALA A . n 
A 1 106 ARG 106 105 105 ARG ARG A . n 
A 1 107 VAL 107 106 106 VAL VAL A . n 
A 1 108 LEU 108 107 107 LEU LEU A . n 
A 1 109 VAL 109 108 108 VAL VAL A . n 
A 1 110 ILE 110 109 109 ILE ILE A . n 
A 1 111 LEU 111 110 110 LEU LEU A . n 
A 1 112 ASN 112 111 111 ASN ASN A . n 
A 1 113 ASN 113 112 112 ASN ASN A . n 
A 1 114 TYR 114 113 113 TYR TYR A . n 
A 1 115 TYR 115 114 114 TYR TYR A . n 
A 1 116 GLN 116 115 115 GLN GLN A . n 
A 1 117 GLN 117 116 116 GLN GLN A . n 
A 1 118 PRO 118 117 117 PRO PRO A . n 
A 1 119 ILE 119 118 118 ILE ILE A . n 
A 1 120 LEU 120 119 119 LEU LEU A . n 
A 1 121 LEU 121 120 120 LEU LEU A . n 
A 1 122 ASN 122 121 121 ASN ASN A . n 
A 1 123 LYS 123 122 122 LYS LYS A . n 
A 1 124 GLU 124 123 123 GLU GLU A . n 
A 1 125 ILE 125 124 124 ILE ILE A . n 
A 1 126 ILE 126 125 125 ILE ILE A . n 
A 1 127 ASN 127 126 126 ASN ASN A . n 
A 1 128 LEU 128 127 127 LEU LEU A . n 
A 1 129 SER 129 128 128 SER SER A . n 
A 1 130 ARG 130 129 129 ARG ARG A . n 
A 1 131 GLY 131 130 130 GLY GLY A . n 
A 1 132 ASP 132 131 131 ASP ASP A . n 
A 1 133 GLU 133 132 132 GLU GLU A . n 
A 1 134 GLY 134 133 133 GLY GLY A . n 
A 1 135 TYR 135 134 134 TYR TYR A . n 
A 1 136 PRO 136 135 135 PRO PRO A . n 
A 1 137 GLU 137 136 136 GLU GLU A . n 
A 1 138 PRO 138 137 137 PRO PRO A . n 
A 1 139 ILE 139 138 138 ILE ILE A . n 
A 1 140 VAL 140 139 139 VAL VAL A . n 
A 1 141 ILE 141 140 140 ILE ILE A . n 
A 1 142 GLU 142 141 141 GLU GLU A . n 
A 1 143 GLN 143 142 142 GLN GLN A . n 
A 1 144 GLY 144 143 143 GLY GLY A . n 
A 1 145 ASN 145 144 144 ASN ASN A . n 
A 1 146 TYR 146 145 145 TYR TYR A . n 
A 1 147 LYS 147 146 146 LYS LYS A . n 
A 1 148 PHE 148 147 147 PHE PHE A . n 
A 1 149 ASN 149 148 148 ASN ASN A . n 
A 1 150 LEU 150 149 149 LEU LEU A . n 
A 1 151 SER 151 150 150 SER SER A . n 
A 1 152 ALA 152 151 151 ALA ALA A . n 
A 1 153 ALA 153 152 152 ALA ALA A . n 
A 1 154 PHE 154 153 153 PHE PHE A . n 
A 1 155 ASP 155 154 154 ASP ASP A . n 
A 1 156 CYS 156 155 155 CYS CYS A . n 
A 1 157 ILE 157 156 156 ILE ILE A . n 
A 1 158 PHE 158 157 157 PHE PHE A . n 
A 1 159 ARG 159 158 158 ARG ARG A . n 
A 1 160 GLU 160 159 159 GLU GLU A . n 
A 1 161 ALA 161 160 160 ALA ALA A . n 
A 1 162 ASP 162 161 161 ASP ASP A . n 
A 1 163 ASP 163 162 162 ASP ASP A . n 
A 1 164 THR 164 163 163 THR THR A . n 
A 1 165 ILE 165 164 164 ILE ILE A . n 
A 1 166 HIS 166 165 165 HIS HIS A . n 
A 1 167 ILE 167 166 166 ILE ILE A . n 
A 1 168 LEU 168 167 167 LEU LEU A . n 
A 1 169 ASP 169 168 168 ASP ASP A . n 
A 1 170 LEU 170 169 169 LEU LEU A . n 
A 1 171 LYS 171 170 170 LYS LYS A . n 
A 1 172 THR 172 171 171 THR THR A . n 
A 1 173 GLY 173 172 172 GLY GLY A . n 
A 1 174 GLN 174 173 173 GLN GLN A . n 
A 1 175 SER 175 174 174 SER SER A . n 
A 1 176 ASN 176 175 175 ASN ASN A . n 
A 1 177 PHE 177 176 176 PHE PHE A . n 
A 1 178 ASP 178 177 177 ASP ASP A . n 
A 1 179 ARG 179 178 178 ARG ARG A . n 
A 1 180 ARG 180 179 179 ARG ARG A . n 
A 1 181 GLN 181 180 180 GLN GLN A . n 
A 1 182 ALA 182 181 181 ALA ALA A . n 
A 1 183 HIS 183 182 182 HIS HIS A . n 
A 1 184 VAL 184 183 183 VAL VAL A . n 
A 1 185 TYR 185 184 184 TYR TYR A . n 
A 1 186 LEU 186 185 185 LEU LEU A . n 
A 1 187 LEU 187 186 186 LEU LEU A . n 
A 1 188 ALA 188 187 187 ALA ALA A . n 
A 1 189 ALA 189 188 188 ALA ALA A . n 
A 1 190 SER 190 189 189 SER SER A . n 
A 1 191 TYR 191 190 190 TYR TYR A . n 
A 1 192 ARG 192 191 191 ARG ARG A . n 
A 1 193 TYR 193 192 192 TYR TYR A . n 
A 1 194 PRO 194 193 193 PRO PRO A . n 
A 1 195 GLN 195 194 194 GLN GLN A . n 
A 1 196 GLU 196 195 195 GLU GLU A . n 
A 1 197 LYS 197 196 196 LYS LYS A . n 
A 1 198 ILE 198 197 197 ILE ILE A . n 
A 1 199 VAL 199 198 198 VAL VAL A . n 
A 1 200 ALA 200 199 199 ALA ALA A . n 
A 1 201 SER 201 200 200 SER SER A . n 
A 1 202 PHE 202 201 201 PHE PHE A . n 
A 1 203 TYR 203 202 202 TYR TYR A . n 
A 1 204 ASN 204 203 203 ASN ASN A . n 
A 1 205 LEU 205 204 204 LEU LEU A . n 
A 1 206 GLU 206 205 205 GLU GLU A . n 
A 1 207 THR 207 206 206 THR THR A . n 
A 1 208 GLN 208 207 207 GLN GLN A . n 
A 1 209 THR 209 208 208 THR THR A . n 
A 1 210 SER 210 209 209 SER SER A . n 
A 1 211 SER 211 210 210 SER SER A . n 
A 1 212 GLU 212 211 211 GLU GLU A . n 
A 1 213 LYS 213 212 212 LYS LYS A . n 
A 1 214 ILE 214 213 213 ILE ILE A . n 
A 1 215 SER 215 214 214 SER SER A . n 
A 1 216 LEU 216 215 215 LEU LEU A . n 
A 1 217 SER 217 216 216 SER SER A . n 
A 1 218 SER 218 217 217 SER SER A . n 
A 1 219 GLU 219 218 218 GLU GLU A . n 
A 1 220 ALA 220 219 219 ALA ALA A . n 
A 1 221 ILE 221 220 220 ILE ILE A . n 
A 1 222 GLU 222 221 221 GLU GLU A . n 
A 1 223 ALA 223 222 222 ALA ALA A . n 
A 1 224 VAL 224 223 223 VAL VAL A . n 
A 1 225 LYS 225 224 224 LYS LYS A . n 
A 1 226 ILE 226 225 225 ILE ILE A . n 
A 1 227 GLU 227 226 226 GLU GLU A . n 
A 1 228 LEU 228 227 227 LEU LEU A . n 
A 1 229 ALA 229 228 228 ALA ALA A . n 
A 1 230 SER 230 229 229 SER SER A . n 
A 1 231 LEU 231 230 230 LEU LEU A . n 
A 1 232 ALA 232 231 231 ALA ALA A . n 
A 1 233 LYS 233 232 232 LYS LYS A . n 
A 1 234 LYS 234 233 233 LYS LYS A . n 
A 1 235 HIS 235 234 234 HIS HIS A . n 
A 1 236 GLN 236 235 235 GLN GLN A . n 
A 1 237 GLN 237 236 236 GLN GLN A . n 
A 1 238 GLN 238 237 237 GLN GLN A . n 
A 1 239 LEU 239 238 238 LEU LEU A . n 
A 1 240 GLN 240 239 239 GLN GLN A . n 
A 1 241 LYS 241 240 240 LYS LYS A . n 
A 1 242 TYR 242 241 241 TYR TYR A . n 
A 1 243 LYS 243 242 242 LYS LYS A . n 
A 1 244 ASP 244 243 243 ASP ASP A . n 
A 1 245 HIS 245 244 244 HIS HIS A . n 
A 1 246 PRO 246 245 245 PRO PRO A . n 
A 1 247 LYS 247 246 246 LYS LYS A . n 
A 1 248 ASP 248 247 247 ASP ASP A . n 
A 1 249 PHE 249 248 248 PHE PHE A . n 
A 1 250 TYR 250 249 249 TYR TYR A . n 
A 1 251 HIS 251 250 250 HIS HIS A . n 
A 1 252 ILE 252 251 251 ILE ILE A . n 
A 1 253 PHE 253 252 252 PHE PHE A . n 
A 1 254 PRO 254 253 253 PRO PRO A . n 
A 1 255 PRO 255 254 254 PRO PRO A . n 
A 1 256 GLN 256 255 255 GLN GLN A . n 
A 1 257 SER 257 256 256 SER SER A . n 
A 1 258 GLY 258 257 257 GLY GLY A . n 
A 1 259 TYR 259 258 258 TYR TYR A . n 
A 1 260 VAL 260 259 259 VAL VAL A . n 
A 1 261 CYS 261 260 260 CYS CYS A . n 
A 1 262 ARG 262 261 261 ARG ARG A . n 
A 1 263 TYR 263 262 262 TYR TYR A . n 
A 1 264 CYS 264 263 263 CYS CYS A . n 
A 1 265 PRO 265 264 264 PRO PRO A . n 
A 1 266 PHE 266 265 265 PHE PHE A . n 
A 1 267 THR 267 266 266 THR THR A . n 
A 1 268 SER 268 267 267 SER SER A . n 
A 1 269 ILE 269 268 268 ILE ILE A . n 
A 1 270 CYS 270 269 269 CYS CYS A . n 
A 1 271 ASP 271 270 270 ASP ASP A . n 
A 1 272 TYR 272 271 271 TYR TYR A . n 
A 1 273 ALA 273 272 272 ALA ALA A . n 
A 1 274 ASN 274 273 273 ASN ASN A . n 
A 1 275 LYS 275 274 274 LYS LYS A . n 
A 1 276 GLU 276 275 275 GLU GLU A . n 
A 1 277 VAL 277 276 ?   ?   ?   A . n 
B 1 1   SER 1   0   ?   ?   ?   B . n 
B 1 2   ALA 2   1   ?   ?   ?   B . n 
B 1 3   SER 3   2   ?   ?   ?   B . n 
B 1 4   CYS 4   3   ?   ?   ?   B . n 
B 1 5   GLN 5   4   ?   ?   ?   B . n 
B 1 6   SER 6   5   ?   ?   ?   B . n 
B 1 7   PRO 7   6   ?   ?   ?   B . n 
B 1 8   LYS 8   7   7   LYS LYS B . n 
B 1 9   LYS 9   8   8   LYS LYS B . n 
B 1 10  PRO 10  9   9   PRO PRO B . n 
B 1 11  TRP 11  10  10  TRP TRP B . n 
B 1 12  TYR 12  11  11  TYR TYR B . n 
B 1 13  PRO 13  12  12  PRO PRO B . n 
B 1 14  PRO 14  13  13  PRO PRO B . n 
B 1 15  MET 15  14  14  MET MET B . n 
B 1 16  SER 16  15  15  SER SER B . n 
B 1 17  TYR 17  16  16  TYR TYR B . n 
B 1 18  SER 18  17  17  SER SER B . n 
B 1 19  LEU 19  18  18  LEU LEU B . n 
B 1 20  TRP 20  19  19  TRP TRP B . n 
B 1 21  ARG 21  20  20  ARG ARG B . n 
B 1 22  SER 22  21  21  SER SER B . n 
B 1 23  LEU 23  22  22  LEU LEU B . n 
B 1 24  LYS 24  23  23  LYS LYS B . n 
B 1 25  PRO 25  24  24  PRO PRO B . n 
B 1 26  ALA 26  25  25  ALA ALA B . n 
B 1 27  ILE 27  26  26  ILE ILE B . n 
B 1 28  GLY 28  27  27  GLY GLY B . n 
B 1 29  TYR 29  28  28  TYR TYR B . n 
B 1 30  GLU 30  29  29  GLU GLU B . n 
B 1 31  ASN 31  30  30  ASN ASN B . n 
B 1 32  TRP 32  31  31  TRP TRP B . n 
B 1 33  HIS 33  32  32  HIS HIS B . n 
B 1 34  CYS 34  33  33  CYS CYS B . n 
B 1 35  GLN 35  34  34  GLN GLN B . n 
B 1 36  THR 36  35  35  THR THR B . n 
B 1 37  LYS 37  36  36  LYS LYS B . n 
B 1 38  ARG 38  37  37  ARG ARG B . n 
B 1 39  GLY 39  38  38  GLY GLY B . n 
B 1 40  PHE 40  39  39  PHE PHE B . n 
B 1 41  GLU 41  40  40  GLU GLU B . n 
B 1 42  LYS 42  41  41  LYS LYS B . n 
B 1 43  ALA 43  42  42  ALA ALA B . n 
B 1 44  ARG 44  43  43  ARG ARG B . n 
B 1 45  ASN 45  44  44  ASN ASN B . n 
B 1 46  LYS 46  45  45  LYS LYS B . n 
B 1 47  GLU 47  46  46  GLU GLU B . n 
B 1 48  PRO 48  47  47  PRO PRO B . n 
B 1 49  GLU 49  48  48  GLU GLU B . n 
B 1 50  VAL 50  49  49  VAL VAL B . n 
B 1 51  GLN 51  50  50  GLN GLN B . n 
B 1 52  ARG 52  51  51  ARG ARG B . n 
B 1 53  LEU 53  52  52  LEU LEU B . n 
B 1 54  LEU 54  53  53  LEU LEU B . n 
B 1 55  SER 55  54  54  SER SER B . n 
B 1 56  GLU 56  55  55  GLU GLU B . n 
B 1 57  ASP 57  56  56  ASP ASP B . n 
B 1 58  ASN 58  57  57  ASN ASN B . n 
B 1 59  GLN 59  58  58  GLN GLN B . n 
B 1 60  PRO 60  59  59  PRO PRO B . n 
B 1 61  GLN 61  60  60  GLN GLN B . n 
B 1 62  LYS 62  61  61  LYS LYS B . n 
B 1 63  ILE 63  62  62  ILE ILE B . n 
B 1 64  GLY 64  63  63  GLY GLY B . n 
B 1 65  LYS 65  64  64  LYS LYS B . n 
B 1 66  LEU 66  65  65  LEU LEU B . n 
B 1 67  ALA 67  66  66  ALA ALA B . n 
B 1 68  GLN 68  67  67  GLN GLN B . n 
B 1 69  ARG 69  68  68  ARG ARG B . n 
B 1 70  GLY 70  69  69  GLY GLY B . n 
B 1 71  VAL 71  70  70  VAL VAL B . n 
B 1 72  PHE 72  71  71  PHE PHE B . n 
B 1 73  GLU 73  72  72  GLU GLU B . n 
B 1 74  PHE 74  73  73  PHE PHE B . n 
B 1 75  HIS 75  74  74  HIS HIS B . n 
B 1 76  GLN 76  75  75  GLN GLN B . n 
B 1 77  GLU 77  76  76  GLU GLU B . n 
B 1 78  LEU 78  77  77  LEU LEU B . n 
B 1 79  VAL 79  78  78  VAL VAL B . n 
B 1 80  ARG 80  79  79  ARG ARG B . n 
B 1 81  LEU 81  80  80  LEU LEU B . n 
B 1 82  SER 82  81  81  SER SER B . n 
B 1 83  GLY 83  82  82  GLY GLY B . n 
B 1 84  SER 84  83  83  SER SER B . n 
B 1 85  HIS 85  84  84  HIS HIS B . n 
B 1 86  GLY 86  85  85  GLY GLY B . n 
B 1 87  VAL 87  86  86  VAL VAL B . n 
B 1 88  GLU 88  87  87  GLU GLU B . n 
B 1 89  GLN 89  88  88  GLN GLN B . n 
B 1 90  VAL 90  89  89  VAL VAL B . n 
B 1 91  ALA 91  90  90  ALA ALA B . n 
B 1 92  GLU 92  91  91  GLU GLU B . n 
B 1 93  ILE 93  92  92  ILE ILE B . n 
B 1 94  LEU 94  93  93  LEU LEU B . n 
B 1 95  GLN 95  94  94  GLN GLN B . n 
B 1 96  LEU 96  95  95  LEU LEU B . n 
B 1 97  ASN 97  96  96  ASN ASN B . n 
B 1 98  GLN 98  97  97  GLN GLN B . n 
B 1 99  GLU 99  98  98  GLU GLU B . n 
B 1 100 SER 100 99  99  SER SER B . n 
B 1 101 PRO 101 100 100 PRO PRO B . n 
B 1 102 GLU 102 101 101 GLU GLU B . n 
B 1 103 ILE 103 102 102 ILE ILE B . n 
B 1 104 GLN 104 103 103 GLN GLN B . n 
B 1 105 ALA 105 104 104 ALA ALA B . n 
B 1 106 ARG 106 105 105 ARG ARG B . n 
B 1 107 VAL 107 106 106 VAL VAL B . n 
B 1 108 LEU 108 107 107 LEU LEU B . n 
B 1 109 VAL 109 108 108 VAL VAL B . n 
B 1 110 ILE 110 109 109 ILE ILE B . n 
B 1 111 LEU 111 110 110 LEU LEU B . n 
B 1 112 ASN 112 111 111 ASN ASN B . n 
B 1 113 ASN 113 112 112 ASN ASN B . n 
B 1 114 TYR 114 113 113 TYR TYR B . n 
B 1 115 TYR 115 114 114 TYR TYR B . n 
B 1 116 GLN 116 115 115 GLN GLN B . n 
B 1 117 GLN 117 116 116 GLN GLN B . n 
B 1 118 PRO 118 117 117 PRO PRO B . n 
B 1 119 ILE 119 118 118 ILE ILE B . n 
B 1 120 LEU 120 119 119 LEU LEU B . n 
B 1 121 LEU 121 120 120 LEU LEU B . n 
B 1 122 ASN 122 121 121 ASN ASN B . n 
B 1 123 LYS 123 122 122 LYS LYS B . n 
B 1 124 GLU 124 123 123 GLU GLU B . n 
B 1 125 ILE 125 124 124 ILE ILE B . n 
B 1 126 ILE 126 125 125 ILE ILE B . n 
B 1 127 ASN 127 126 126 ASN ASN B . n 
B 1 128 LEU 128 127 127 LEU LEU B . n 
B 1 129 SER 129 128 128 SER SER B . n 
B 1 130 ARG 130 129 129 ARG ARG B . n 
B 1 131 GLY 131 130 130 GLY GLY B . n 
B 1 132 ASP 132 131 131 ASP ASP B . n 
B 1 133 GLU 133 132 132 GLU GLU B . n 
B 1 134 GLY 134 133 133 GLY GLY B . n 
B 1 135 TYR 135 134 134 TYR TYR B . n 
B 1 136 PRO 136 135 135 PRO PRO B . n 
B 1 137 GLU 137 136 136 GLU GLU B . n 
B 1 138 PRO 138 137 137 PRO PRO B . n 
B 1 139 ILE 139 138 138 ILE ILE B . n 
B 1 140 VAL 140 139 139 VAL VAL B . n 
B 1 141 ILE 141 140 140 ILE ILE B . n 
B 1 142 GLU 142 141 141 GLU GLU B . n 
B 1 143 GLN 143 142 142 GLN GLN B . n 
B 1 144 GLY 144 143 143 GLY GLY B . n 
B 1 145 ASN 145 144 144 ASN ASN B . n 
B 1 146 TYR 146 145 145 TYR TYR B . n 
B 1 147 LYS 147 146 146 LYS LYS B . n 
B 1 148 PHE 148 147 147 PHE PHE B . n 
B 1 149 ASN 149 148 148 ASN ASN B . n 
B 1 150 LEU 150 149 149 LEU LEU B . n 
B 1 151 SER 151 150 150 SER SER B . n 
B 1 152 ALA 152 151 151 ALA ALA B . n 
B 1 153 ALA 153 152 152 ALA ALA B . n 
B 1 154 PHE 154 153 153 PHE PHE B . n 
B 1 155 ASP 155 154 154 ASP ASP B . n 
B 1 156 CYS 156 155 155 CYS CYS B . n 
B 1 157 ILE 157 156 156 ILE ILE B . n 
B 1 158 PHE 158 157 157 PHE PHE B . n 
B 1 159 ARG 159 158 158 ARG ARG B . n 
B 1 160 GLU 160 159 159 GLU GLU B . n 
B 1 161 ALA 161 160 160 ALA ALA B . n 
B 1 162 ASP 162 161 161 ASP ASP B . n 
B 1 163 ASP 163 162 162 ASP ASP B . n 
B 1 164 THR 164 163 163 THR THR B . n 
B 1 165 ILE 165 164 164 ILE ILE B . n 
B 1 166 HIS 166 165 165 HIS HIS B . n 
B 1 167 ILE 167 166 166 ILE ILE B . n 
B 1 168 LEU 168 167 167 LEU LEU B . n 
B 1 169 ASP 169 168 168 ASP ASP B . n 
B 1 170 LEU 170 169 169 LEU LEU B . n 
B 1 171 LYS 171 170 170 LYS LYS B . n 
B 1 172 THR 172 171 171 THR THR B . n 
B 1 173 GLY 173 172 172 GLY GLY B . n 
B 1 174 GLN 174 173 173 GLN GLN B . n 
B 1 175 SER 175 174 174 SER SER B . n 
B 1 176 ASN 176 175 175 ASN ASN B . n 
B 1 177 PHE 177 176 176 PHE PHE B . n 
B 1 178 ASP 178 177 177 ASP ASP B . n 
B 1 179 ARG 179 178 178 ARG ARG B . n 
B 1 180 ARG 180 179 179 ARG ARG B . n 
B 1 181 GLN 181 180 180 GLN GLN B . n 
B 1 182 ALA 182 181 181 ALA ALA B . n 
B 1 183 HIS 183 182 182 HIS HIS B . n 
B 1 184 VAL 184 183 183 VAL VAL B . n 
B 1 185 TYR 185 184 184 TYR TYR B . n 
B 1 186 LEU 186 185 185 LEU LEU B . n 
B 1 187 LEU 187 186 186 LEU LEU B . n 
B 1 188 ALA 188 187 187 ALA ALA B . n 
B 1 189 ALA 189 188 188 ALA ALA B . n 
B 1 190 SER 190 189 189 SER SER B . n 
B 1 191 TYR 191 190 190 TYR TYR B . n 
B 1 192 ARG 192 191 191 ARG ARG B . n 
B 1 193 TYR 193 192 192 TYR TYR B . n 
B 1 194 PRO 194 193 193 PRO PRO B . n 
B 1 195 GLN 195 194 194 GLN GLN B . n 
B 1 196 GLU 196 195 195 GLU GLU B . n 
B 1 197 LYS 197 196 196 LYS LYS B . n 
B 1 198 ILE 198 197 197 ILE ILE B . n 
B 1 199 VAL 199 198 198 VAL VAL B . n 
B 1 200 ALA 200 199 199 ALA ALA B . n 
B 1 201 SER 201 200 200 SER SER B . n 
B 1 202 PHE 202 201 201 PHE PHE B . n 
B 1 203 TYR 203 202 202 TYR TYR B . n 
B 1 204 ASN 204 203 203 ASN ASN B . n 
B 1 205 LEU 205 204 204 LEU LEU B . n 
B 1 206 GLU 206 205 205 GLU GLU B . n 
B 1 207 THR 207 206 206 THR THR B . n 
B 1 208 GLN 208 207 207 GLN GLN B . n 
B 1 209 THR 209 208 208 THR THR B . n 
B 1 210 SER 210 209 209 SER SER B . n 
B 1 211 SER 211 210 210 SER SER B . n 
B 1 212 GLU 212 211 211 GLU GLU B . n 
B 1 213 LYS 213 212 212 LYS LYS B . n 
B 1 214 ILE 214 213 213 ILE ILE B . n 
B 1 215 SER 215 214 214 SER SER B . n 
B 1 216 LEU 216 215 215 LEU LEU B . n 
B 1 217 SER 217 216 216 SER SER B . n 
B 1 218 SER 218 217 217 SER SER B . n 
B 1 219 GLU 219 218 218 GLU GLU B . n 
B 1 220 ALA 220 219 219 ALA ALA B . n 
B 1 221 ILE 221 220 220 ILE ILE B . n 
B 1 222 GLU 222 221 221 GLU GLU B . n 
B 1 223 ALA 223 222 222 ALA ALA B . n 
B 1 224 VAL 224 223 223 VAL VAL B . n 
B 1 225 LYS 225 224 224 LYS LYS B . n 
B 1 226 ILE 226 225 225 ILE ILE B . n 
B 1 227 GLU 227 226 226 GLU GLU B . n 
B 1 228 LEU 228 227 227 LEU LEU B . n 
B 1 229 ALA 229 228 228 ALA ALA B . n 
B 1 230 SER 230 229 229 SER SER B . n 
B 1 231 LEU 231 230 230 LEU LEU B . n 
B 1 232 ALA 232 231 231 ALA ALA B . n 
B 1 233 LYS 233 232 232 LYS LYS B . n 
B 1 234 LYS 234 233 233 LYS LYS B . n 
B 1 235 HIS 235 234 234 HIS HIS B . n 
B 1 236 GLN 236 235 235 GLN GLN B . n 
B 1 237 GLN 237 236 236 GLN GLN B . n 
B 1 238 GLN 238 237 237 GLN GLN B . n 
B 1 239 LEU 239 238 238 LEU LEU B . n 
B 1 240 GLN 240 239 239 GLN GLN B . n 
B 1 241 LYS 241 240 240 LYS LYS B . n 
B 1 242 TYR 242 241 241 TYR TYR B . n 
B 1 243 LYS 243 242 242 LYS LYS B . n 
B 1 244 ASP 244 243 243 ASP ASP B . n 
B 1 245 HIS 245 244 244 HIS HIS B . n 
B 1 246 PRO 246 245 245 PRO PRO B . n 
B 1 247 LYS 247 246 246 LYS LYS B . n 
B 1 248 ASP 248 247 247 ASP ASP B . n 
B 1 249 PHE 249 248 248 PHE PHE B . n 
B 1 250 TYR 250 249 249 TYR TYR B . n 
B 1 251 HIS 251 250 250 HIS HIS B . n 
B 1 252 ILE 252 251 251 ILE ILE B . n 
B 1 253 PHE 253 252 252 PHE PHE B . n 
B 1 254 PRO 254 253 253 PRO PRO B . n 
B 1 255 PRO 255 254 254 PRO PRO B . n 
B 1 256 GLN 256 255 255 GLN GLN B . n 
B 1 257 SER 257 256 256 SER SER B . n 
B 1 258 GLY 258 257 257 GLY GLY B . n 
B 1 259 TYR 259 258 258 TYR TYR B . n 
B 1 260 VAL 260 259 259 VAL VAL B . n 
B 1 261 CYS 261 260 260 CYS CYS B . n 
B 1 262 ARG 262 261 261 ARG ARG B . n 
B 1 263 TYR 263 262 262 TYR TYR B . n 
B 1 264 CYS 264 263 263 CYS CYS B . n 
B 1 265 PRO 265 264 264 PRO PRO B . n 
B 1 266 PHE 266 265 265 PHE PHE B . n 
B 1 267 THR 267 266 266 THR THR B . n 
B 1 268 SER 268 267 267 SER SER B . n 
B 1 269 ILE 269 268 268 ILE ILE B . n 
B 1 270 CYS 270 269 269 CYS CYS B . n 
B 1 271 ASP 271 270 270 ASP ASP B . n 
B 1 272 TYR 272 271 271 TYR TYR B . n 
B 1 273 ALA 273 272 272 ALA ALA B . n 
B 1 274 ASN 274 273 273 ASN ASN B . n 
B 1 275 LYS 275 274 274 LYS LYS B . n 
B 1 276 GLU 276 275 275 GLU GLU B . n 
B 1 277 VAL 277 276 ?   ?   ?   B . n 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
C 2 SF4 1  301 300 SF4 SF4 A . 
D 3 MG  1  302 1   MG  MG  A . 
E 4 EDO 1  303 3   EDO EDO A . 
F 4 EDO 1  304 4   EDO EDO A . 
G 4 EDO 1  305 5   EDO EDO A . 
H 2 SF4 1  301 300 SF4 SF4 B . 
I 4 EDO 1  302 136 EDO EDO B . 
J 3 MG  1  303 2   MG  MG  B . 
K 4 EDO 1  304 1   EDO EDO B . 
L 4 EDO 1  305 2   EDO EDO B . 
M 5 HOH 1  401 204 HOH HOH A . 
M 5 HOH 2  402 65  HOH HOH A . 
M 5 HOH 3  403 17  HOH HOH A . 
M 5 HOH 4  404 96  HOH HOH A . 
M 5 HOH 5  405 14  HOH HOH A . 
M 5 HOH 6  406 79  HOH HOH A . 
M 5 HOH 7  407 117 HOH HOH A . 
M 5 HOH 8  408 205 HOH HOH A . 
M 5 HOH 9  409 207 HOH HOH A . 
M 5 HOH 10 410 2   HOH HOH A . 
M 5 HOH 11 411 3   HOH HOH A . 
M 5 HOH 12 412 19  HOH HOH A . 
M 5 HOH 13 413 120 HOH HOH A . 
M 5 HOH 14 414 209 HOH HOH A . 
M 5 HOH 15 415 62  HOH HOH A . 
M 5 HOH 16 416 115 HOH HOH A . 
M 5 HOH 17 417 93  HOH HOH A . 
M 5 HOH 18 418 67  HOH HOH A . 
M 5 HOH 19 419 86  HOH HOH A . 
M 5 HOH 20 420 47  HOH HOH A . 
M 5 HOH 21 421 37  HOH HOH A . 
M 5 HOH 22 422 203 HOH HOH A . 
M 5 HOH 23 423 202 HOH HOH A . 
M 5 HOH 24 424 118 HOH HOH A . 
M 5 HOH 25 425 85  HOH HOH A . 
M 5 HOH 26 426 87  HOH HOH A . 
M 5 HOH 27 427 97  HOH HOH A . 
M 5 HOH 28 428 208 HOH HOH A . 
N 5 HOH 1  401 29  HOH HOH B . 
N 5 HOH 2  402 7   HOH HOH B . 
N 5 HOH 3  403 102 HOH HOH B . 
N 5 HOH 4  404 124 HOH HOH B . 
N 5 HOH 5  405 9   HOH HOH B . 
N 5 HOH 6  406 43  HOH HOH B . 
N 5 HOH 7  407 5   HOH HOH B . 
N 5 HOH 8  408 28  HOH HOH B . 
N 5 HOH 9  409 1   HOH HOH B . 
N 5 HOH 10 410 44  HOH HOH B . 
N 5 HOH 11 411 38  HOH HOH B . 
N 5 HOH 12 412 113 HOH HOH B . 
N 5 HOH 13 413 63  HOH HOH B . 
N 5 HOH 14 414 109 HOH HOH B . 
N 5 HOH 15 415 22  HOH HOH B . 
N 5 HOH 16 416 101 HOH HOH B . 
N 5 HOH 17 417 107 HOH HOH B . 
N 5 HOH 18 418 127 HOH HOH B . 
N 5 HOH 19 419 201 HOH HOH B . 
N 5 HOH 20 420 131 HOH HOH B . 
N 5 HOH 21 421 114 HOH HOH B . 
N 5 HOH 22 422 116 HOH HOH B . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1  1 Y 1 A LYS 8   ? CG  ? A LYS 9   CG  
2  1 Y 1 A LYS 8   ? CD  ? A LYS 9   CD  
3  1 Y 1 A LYS 8   ? CE  ? A LYS 9   CE  
4  1 Y 1 A LYS 8   ? NZ  ? A LYS 9   NZ  
5  1 Y 1 B LYS 7   ? CG  ? B LYS 8   CG  
6  1 Y 1 B LYS 7   ? CD  ? B LYS 8   CD  
7  1 Y 1 B LYS 7   ? CE  ? B LYS 8   CE  
8  1 Y 1 B LYS 7   ? NZ  ? B LYS 8   NZ  
9  1 Y 1 B LYS 8   ? CG  ? B LYS 9   CG  
10 1 Y 1 B LYS 8   ? CD  ? B LYS 9   CD  
11 1 Y 1 B LYS 8   ? CE  ? B LYS 9   CE  
12 1 Y 1 B LYS 8   ? NZ  ? B LYS 9   NZ  
13 1 Y 1 B TYR 262 ? CG  ? B TYR 263 CG  
14 1 Y 1 B TYR 262 ? CD1 ? B TYR 263 CD1 
15 1 Y 1 B TYR 262 ? CD2 ? B TYR 263 CD2 
16 1 Y 1 B TYR 262 ? CE1 ? B TYR 263 CE1 
17 1 Y 1 B TYR 262 ? CE2 ? B TYR 263 CE2 
18 1 Y 1 B TYR 262 ? CZ  ? B TYR 263 CZ  
19 1 Y 1 B TYR 262 ? OH  ? B TYR 263 OH  
# 
loop_
_software.citation_id 
_software.classification 
_software.compiler_name 
_software.compiler_version 
_software.contact_author 
_software.contact_author_email 
_software.date 
_software.description 
_software.dependencies 
_software.hardware 
_software.language 
_software.location 
_software.mods 
_software.name 
_software.os 
_software.os_version 
_software.type 
_software.version 
_software.pdbx_ordinal 
? 'data reduction' ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           1 
? 'data scaling'   ? ? ? ? ? ? ? ? ? ? ? XDS    ? ? ? .           2 
? refinement       ? ? ? ? ? ? ? ? ? ? ? PHENIX ? ? ? 1.20.1_4487 3 
? phasing          ? ? ? ? ? ? ? ? ? ? ? PHASER ? ? ? .           4 
? 'model building' ? ? ? ? ? ? ? ? ? ? ? Coot   ? ? ? .           5 
# 
_cell.angle_alpha                  90.000 
_cell.angle_alpha_esd              ? 
_cell.angle_beta                   90.000 
_cell.angle_beta_esd               ? 
_cell.angle_gamma                  90.000 
_cell.angle_gamma_esd              ? 
_cell.entry_id                     9IAC 
_cell.details                      ? 
_cell.formula_units_Z              ? 
_cell.length_a                     77.858 
_cell.length_a_esd                 ? 
_cell.length_b                     77.872 
_cell.length_b_esd                 ? 
_cell.length_c                     110.453 
_cell.length_c_esd                 ? 
_cell.volume                       669671.919 
_cell.volume_esd                   ? 
_cell.Z_PDB                        8 
_cell.reciprocal_angle_alpha       ? 
_cell.reciprocal_angle_beta        ? 
_cell.reciprocal_angle_gamma       ? 
_cell.reciprocal_angle_alpha_esd   ? 
_cell.reciprocal_angle_beta_esd    ? 
_cell.reciprocal_angle_gamma_esd   ? 
_cell.reciprocal_length_a          ? 
_cell.reciprocal_length_b          ? 
_cell.reciprocal_length_c          ? 
_cell.reciprocal_length_a_esd      ? 
_cell.reciprocal_length_b_esd      ? 
_cell.reciprocal_length_c_esd      ? 
_cell.pdbx_unique_axis             ? 
_cell.pdbx_esd_method              ? 
# 
_symmetry.entry_id                         9IAC 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                19 
_symmetry.space_group_name_Hall            'P 2ac 2ab' 
_symmetry.space_group_name_H-M             'P 21 21 21' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
# 
_exptl.absorpt_coefficient_mu     ? 
_exptl.absorpt_correction_T_max   ? 
_exptl.absorpt_correction_T_min   ? 
_exptl.absorpt_correction_type    ? 
_exptl.absorpt_process_details    ? 
_exptl.entry_id                   9IAC 
_exptl.crystals_number            1 
_exptl.details                    ? 
_exptl.method                     'X-RAY DIFFRACTION' 
_exptl.method_details             ? 
# 
_exptl_crystal.colour                       ? 
_exptl_crystal.density_diffrn               ? 
_exptl_crystal.density_Matthews             2.61 
_exptl_crystal.density_method               ? 
_exptl_crystal.density_percent_sol          52.89 
_exptl_crystal.description                  ? 
_exptl_crystal.F_000                        ? 
_exptl_crystal.id                           1 
_exptl_crystal.preparation                  ? 
_exptl_crystal.size_max                     ? 
_exptl_crystal.size_mid                     ? 
_exptl_crystal.size_min                     ? 
_exptl_crystal.size_rad                     ? 
_exptl_crystal.colour_lustre                ? 
_exptl_crystal.colour_modifier              ? 
_exptl_crystal.colour_primary               ? 
_exptl_crystal.density_meas                 ? 
_exptl_crystal.density_meas_esd             ? 
_exptl_crystal.density_meas_gt              ? 
_exptl_crystal.density_meas_lt              ? 
_exptl_crystal.density_meas_temp            ? 
_exptl_crystal.density_meas_temp_esd        ? 
_exptl_crystal.density_meas_temp_gt         ? 
_exptl_crystal.density_meas_temp_lt         ? 
_exptl_crystal.pdbx_crystal_image_url       ? 
_exptl_crystal.pdbx_crystal_image_format    ? 
_exptl_crystal.pdbx_mosaicity               ? 
_exptl_crystal.pdbx_mosaicity_esd           ? 
_exptl_crystal.pdbx_mosaic_method           ? 
_exptl_crystal.pdbx_mosaic_block_size       ? 
_exptl_crystal.pdbx_mosaic_block_size_esd   ? 
# 
_exptl_crystal_grow.apparatus       ? 
_exptl_crystal_grow.atmosphere      ? 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.details         ? 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, HANGING DROP' 
_exptl_crystal_grow.method_ref      ? 
_exptl_crystal_grow.pH              5.5 
_exptl_crystal_grow.pressure        ? 
_exptl_crystal_grow.pressure_esd    ? 
_exptl_crystal_grow.seeding         ? 
_exptl_crystal_grow.seeding_ref     ? 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.temp_esd        ? 
_exptl_crystal_grow.time            ? 
_exptl_crystal_grow.pdbx_details    
;Protein solution:
-10 mM HEPES-KOH pH 7.5
-250 mM KCl
-1 mM DTT

Reservoir solution:
-0.1 M Bis-Tris pH 5.5
-0.2 M MgCl2
-23% PEG3350
;
_exptl_crystal_grow.pdbx_pH_range   ? 
_exptl_crystal_grow.temp            293 
# 
_diffrn.ambient_environment              ? 
_diffrn.ambient_temp                     100 
_diffrn.ambient_temp_details             ? 
_diffrn.ambient_temp_esd                 ? 
_diffrn.crystal_id                       1 
_diffrn.crystal_support                  ? 
_diffrn.crystal_treatment                ? 
_diffrn.details                          ? 
_diffrn.id                               1 
_diffrn.ambient_pressure                 ? 
_diffrn.ambient_pressure_esd             ? 
_diffrn.ambient_pressure_gt              ? 
_diffrn.ambient_pressure_lt              ? 
_diffrn.ambient_temp_gt                  ? 
_diffrn.ambient_temp_lt                  ? 
_diffrn.pdbx_serial_crystal_experiment   N 
# 
_diffrn_detector.details                      ? 
_diffrn_detector.detector                     PIXEL 
_diffrn_detector.diffrn_id                    1 
_diffrn_detector.type                         'DECTRIS PILATUS 2M-F' 
_diffrn_detector.area_resol_mean              ? 
_diffrn_detector.dtime                        ? 
_diffrn_detector.pdbx_frames_total            ? 
_diffrn_detector.pdbx_collection_time_total   ? 
_diffrn_detector.pdbx_collection_date         2017-05-21 
_diffrn_detector.pdbx_frequency               ? 
_diffrn_detector.id                           ? 
_diffrn_detector.number_of_axes               ? 
# 
_diffrn_radiation.collimation                      ? 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.filter_edge                      ? 
_diffrn_radiation.inhomogeneity                    ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.polarisn_norm                    ? 
_diffrn_radiation.polarisn_ratio                   ? 
_diffrn_radiation.probe                            ? 
_diffrn_radiation.type                             ? 
_diffrn_radiation.xray_symbol                      ? 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   M 
_diffrn_radiation.pdbx_wavelength_list             ? 
_diffrn_radiation.pdbx_wavelength                  ? 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_analyzer                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   1.00003 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.current                     ? 
_diffrn_source.details                     ? 
_diffrn_source.diffrn_id                   1 
_diffrn_source.power                       ? 
_diffrn_source.size                        ? 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.target                      ? 
_diffrn_source.type                        'SLS BEAMLINE X06DA' 
_diffrn_source.voltage                     ? 
_diffrn_source.take-off_angle              ? 
_diffrn_source.pdbx_wavelength_list        1.00003 
_diffrn_source.pdbx_wavelength             ? 
_diffrn_source.pdbx_synchrotron_beamline   X06DA 
_diffrn_source.pdbx_synchrotron_site       SLS 
# 
_reflns.B_iso_Wilson_estimate                          53.39 
_reflns.entry_id                                       9IAC 
_reflns.data_reduction_details                         ? 
_reflns.data_reduction_method                          ? 
_reflns.d_resolution_high                              2.52 
_reflns.d_resolution_low                               55.23 
_reflns.details                                        ? 
_reflns.limit_h_max                                    ? 
_reflns.limit_h_min                                    ? 
_reflns.limit_k_max                                    ? 
_reflns.limit_k_min                                    ? 
_reflns.limit_l_max                                    ? 
_reflns.limit_l_min                                    ? 
_reflns.number_all                                     ? 
_reflns.number_obs                                     23331 
_reflns.observed_criterion                             ? 
_reflns.observed_criterion_F_max                       ? 
_reflns.observed_criterion_F_min                       ? 
_reflns.observed_criterion_I_max                       ? 
_reflns.observed_criterion_I_min                       ? 
_reflns.observed_criterion_sigma_F                     ? 
_reflns.observed_criterion_sigma_I                     ? 
_reflns.percent_possible_obs                           99.29 
_reflns.R_free_details                                 ? 
_reflns.Rmerge_F_all                                   ? 
_reflns.Rmerge_F_obs                                   ? 
_reflns.Friedel_coverage                               ? 
_reflns.number_gt                                      ? 
_reflns.threshold_expression                           ? 
_reflns.pdbx_redundancy                                2.0 
_reflns.pdbx_netI_over_av_sigmaI                       ? 
_reflns.pdbx_netI_over_sigmaI                          17.52 
_reflns.pdbx_res_netI_over_av_sigmaI_2                 ? 
_reflns.pdbx_res_netI_over_sigmaI_2                    ? 
_reflns.pdbx_chi_squared                               ? 
_reflns.pdbx_scaling_rejects                           ? 
_reflns.pdbx_d_res_high_opt                            ? 
_reflns.pdbx_d_res_low_opt                             ? 
_reflns.pdbx_d_res_opt_method                          ? 
_reflns.phase_calculation_details                      ? 
_reflns.pdbx_Rrim_I_all                                0.036 
_reflns.pdbx_Rpim_I_all                                ? 
_reflns.pdbx_d_opt                                     ? 
_reflns.pdbx_number_measured_all                       ? 
_reflns.pdbx_diffrn_id                                 1 
_reflns.pdbx_ordinal                                   1 
_reflns.pdbx_CC_half                                   1 
_reflns.pdbx_CC_star                                   ? 
_reflns.pdbx_R_split                                   ? 
_reflns.pdbx_Rmerge_I_obs                              ? 
_reflns.pdbx_Rmerge_I_all                              ? 
_reflns.pdbx_Rsym_value                                ? 
_reflns.pdbx_CC_split_method                           ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_1_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_2_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[1]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[2]   ? 
_reflns.pdbx_aniso_diffraction_limit_axis_3_ortho[3]   ? 
_reflns.pdbx_aniso_diffraction_limit_1                 ? 
_reflns.pdbx_aniso_diffraction_limit_2                 ? 
_reflns.pdbx_aniso_diffraction_limit_3                 ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_1_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_2_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[1]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[2]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvector_3_ortho[3]     ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_1               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_2               ? 
_reflns.pdbx_aniso_B_tensor_eigenvalue_3               ? 
_reflns.pdbx_orthogonalization_convention              ? 
_reflns.pdbx_percent_possible_ellipsoidal              ? 
_reflns.pdbx_percent_possible_spherical                ? 
_reflns.pdbx_percent_possible_ellipsoidal_anomalous    ? 
_reflns.pdbx_percent_possible_spherical_anomalous      ? 
_reflns.pdbx_redundancy_anomalous                      ? 
_reflns.pdbx_CC_half_anomalous                         ? 
_reflns.pdbx_absDiff_over_sigma_anomalous              ? 
_reflns.pdbx_percent_possible_anomalous                ? 
_reflns.pdbx_observed_signal_threshold                 ? 
_reflns.pdbx_signal_type                               ? 
_reflns.pdbx_signal_details                            ? 
_reflns.pdbx_signal_software_id                        ? 
# 
_reflns_shell.d_res_high                                    2.52 
_reflns_shell.d_res_low                                     2.61 
_reflns_shell.meanI_over_sigI_all                           ? 
_reflns_shell.meanI_over_sigI_obs                           2.42 
_reflns_shell.number_measured_all                           ? 
_reflns_shell.number_measured_obs                           ? 
_reflns_shell.number_possible                               ? 
_reflns_shell.number_unique_all                             ? 
_reflns_shell.number_unique_obs                             2276 
_reflns_shell.percent_possible_obs                          ? 
_reflns_shell.Rmerge_F_all                                  ? 
_reflns_shell.Rmerge_F_obs                                  ? 
_reflns_shell.meanI_over_sigI_gt                            ? 
_reflns_shell.meanI_over_uI_all                             ? 
_reflns_shell.meanI_over_uI_gt                              ? 
_reflns_shell.number_measured_gt                            ? 
_reflns_shell.number_unique_gt                              ? 
_reflns_shell.percent_possible_gt                           ? 
_reflns_shell.Rmerge_F_gt                                   ? 
_reflns_shell.Rmerge_I_gt                                   ? 
_reflns_shell.pdbx_redundancy                               ? 
_reflns_shell.pdbx_chi_squared                              ? 
_reflns_shell.pdbx_netI_over_sigmaI_all                     ? 
_reflns_shell.pdbx_netI_over_sigmaI_obs                     ? 
_reflns_shell.pdbx_Rrim_I_all                               0.405 
_reflns_shell.pdbx_Rpim_I_all                               ? 
_reflns_shell.pdbx_rejects                                  ? 
_reflns_shell.pdbx_ordinal                                  1 
_reflns_shell.pdbx_diffrn_id                                1 
_reflns_shell.pdbx_CC_half                                  0.938 
_reflns_shell.pdbx_CC_star                                  ? 
_reflns_shell.pdbx_R_split                                  ? 
_reflns_shell.percent_possible_all                          ? 
_reflns_shell.Rmerge_I_all                                  ? 
_reflns_shell.Rmerge_I_obs                                  ? 
_reflns_shell.pdbx_Rsym_value                               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal             ? 
_reflns_shell.pdbx_percent_possible_spherical               ? 
_reflns_shell.pdbx_percent_possible_ellipsoidal_anomalous   ? 
_reflns_shell.pdbx_percent_possible_spherical_anomalous     ? 
_reflns_shell.pdbx_redundancy_anomalous                     ? 
_reflns_shell.pdbx_CC_half_anomalous                        ? 
_reflns_shell.pdbx_absDiff_over_sigma_anomalous             ? 
_reflns_shell.pdbx_percent_possible_anomalous               ? 
# 
_refine.aniso_B[1][1]                            ? 
_refine.aniso_B[1][2]                            ? 
_refine.aniso_B[1][3]                            ? 
_refine.aniso_B[2][2]                            ? 
_refine.aniso_B[2][3]                            ? 
_refine.aniso_B[3][3]                            ? 
_refine.B_iso_max                                ? 
_refine.B_iso_mean                               68.30 
_refine.B_iso_min                                ? 
_refine.correlation_coeff_Fo_to_Fc               ? 
_refine.correlation_coeff_Fo_to_Fc_free          ? 
_refine.details                                  ? 
_refine.diff_density_max                         ? 
_refine.diff_density_max_esd                     ? 
_refine.diff_density_min                         ? 
_refine.diff_density_min_esd                     ? 
_refine.diff_density_rms                         ? 
_refine.diff_density_rms_esd                     ? 
_refine.entry_id                                 9IAC 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.ls_abs_structure_details                 ? 
_refine.ls_abs_structure_Flack                   ? 
_refine.ls_abs_structure_Flack_esd               ? 
_refine.ls_abs_structure_Rogers                  ? 
_refine.ls_abs_structure_Rogers_esd              ? 
_refine.ls_d_res_high                            2.52 
_refine.ls_d_res_low                             55.23 
_refine.ls_extinction_coef                       ? 
_refine.ls_extinction_coef_esd                   ? 
_refine.ls_extinction_expression                 ? 
_refine.ls_extinction_method                     ? 
_refine.ls_goodness_of_fit_all                   ? 
_refine.ls_goodness_of_fit_all_esd               ? 
_refine.ls_goodness_of_fit_obs                   ? 
_refine.ls_goodness_of_fit_obs_esd               ? 
_refine.ls_hydrogen_treatment                    ? 
_refine.ls_matrix_type                           ? 
_refine.ls_number_constraints                    ? 
_refine.ls_number_parameters                     ? 
_refine.ls_number_reflns_all                     ? 
_refine.ls_number_reflns_obs                     23188 
_refine.ls_number_reflns_R_free                  1153 
_refine.ls_number_reflns_R_work                  22035 
_refine.ls_number_restraints                     ? 
_refine.ls_percent_reflns_obs                    99.29 
_refine.ls_percent_reflns_R_free                 4.97 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_obs                          0.2628 
_refine.ls_R_factor_R_free                       0.2952 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_R_factor_R_work                       0.2611 
_refine.ls_R_Fsqd_factor_obs                     ? 
_refine.ls_R_I_factor_obs                        ? 
_refine.ls_redundancy_reflns_all                 ? 
_refine.ls_redundancy_reflns_obs                 ? 
_refine.ls_restrained_S_all                      ? 
_refine.ls_restrained_S_obs                      ? 
_refine.ls_shift_over_esd_max                    ? 
_refine.ls_shift_over_esd_mean                   ? 
_refine.ls_structure_factor_coef                 ? 
_refine.ls_weighting_details                     ? 
_refine.ls_weighting_scheme                      ? 
_refine.ls_wR_factor_all                         ? 
_refine.ls_wR_factor_obs                         ? 
_refine.ls_wR_factor_R_free                      ? 
_refine.ls_wR_factor_R_work                      ? 
_refine.occupancy_max                            ? 
_refine.occupancy_min                            ? 
_refine.solvent_model_details                    'FLAT BULK SOLVENT MODEL' 
_refine.solvent_model_param_bsol                 ? 
_refine.solvent_model_param_ksol                 ? 
_refine.pdbx_R_complete                          ? 
_refine.ls_R_factor_gt                           ? 
_refine.ls_goodness_of_fit_gt                    ? 
_refine.ls_goodness_of_fit_ref                   ? 
_refine.ls_shift_over_su_max                     ? 
_refine.ls_shift_over_su_max_lt                  ? 
_refine.ls_shift_over_su_mean                    ? 
_refine.ls_shift_over_su_mean_lt                 ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          1.34 
_refine.pdbx_ls_sigma_Fsqd                       ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_ls_cross_valid_method               'FREE R-VALUE' 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_stereochemistry_target_values       'GeoStd + Monomer Library + CDL v1.2' 
_refine.pdbx_R_Free_selection_details            ? 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_overall_ESU_R                       ? 
_refine.pdbx_overall_ESU_R_Free                  ? 
_refine.pdbx_solvent_vdw_probe_radii             1.1000 
_refine.pdbx_solvent_ion_probe_radii             ? 
_refine.pdbx_solvent_shrinkage_radii             0.9000 
_refine.pdbx_real_space_R                        ? 
_refine.pdbx_density_correlation                 ? 
_refine.pdbx_pd_number_of_powder_patterns        ? 
_refine.pdbx_pd_number_of_points                 ? 
_refine.pdbx_pd_meas_number_of_points            ? 
_refine.pdbx_pd_proc_ls_prof_R_factor            ? 
_refine.pdbx_pd_proc_ls_prof_wR_factor           ? 
_refine.pdbx_pd_Marquardt_correlation_coeff      ? 
_refine.pdbx_pd_Fsqrd_R_factor                   ? 
_refine.pdbx_pd_ls_matrix_band_width             ? 
_refine.pdbx_overall_phase_error                 39.8900 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.pdbx_diffrn_id                           1 
_refine.overall_SU_B                             ? 
_refine.overall_SU_ML                            0.4644 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.overall_SU_R_free                        ? 
_refine.overall_FOM_free_R_set                   ? 
_refine.overall_FOM_work_R_set                   ? 
_refine.pdbx_average_fsc_overall                 ? 
_refine.pdbx_average_fsc_work                    ? 
_refine.pdbx_average_fsc_free                    ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         LAST 
_refine_hist.details                          ? 
_refine_hist.d_res_high                       2.52 
_refine_hist.d_res_low                        55.23 
_refine_hist.number_atoms_solvent             50 
_refine_hist.number_atoms_total               4482 
_refine_hist.number_reflns_all                ? 
_refine_hist.number_reflns_obs                ? 
_refine_hist.number_reflns_R_free             ? 
_refine_hist.number_reflns_R_work             ? 
_refine_hist.R_factor_all                     ? 
_refine_hist.R_factor_obs                     ? 
_refine_hist.R_factor_R_free                  ? 
_refine_hist.R_factor_R_work                  ? 
_refine_hist.pdbx_number_residues_total       ? 
_refine_hist.pdbx_B_iso_mean_ligand           ? 
_refine_hist.pdbx_B_iso_mean_solvent          ? 
_refine_hist.pdbx_number_atoms_protein        4390 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         42 
_refine_hist.pdbx_number_atoms_lipid          ? 
_refine_hist.pdbx_number_atoms_carb           ? 
_refine_hist.pdbx_pseudo_atom_details         ? 
# 
loop_
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.criterion 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.number 
_refine_ls_restr.rejects 
_refine_ls_restr.type 
_refine_ls_restr.weight 
_refine_ls_restr.pdbx_restraint_function 
'X-RAY DIFFRACTION' ? 0.0033  ? 4541 ? f_bond_d           ? ? 
'X-RAY DIFFRACTION' ? 0.5862  ? 6150 ? f_angle_d          ? ? 
'X-RAY DIFFRACTION' ? 0.0415  ? 637  ? f_chiral_restr     ? ? 
'X-RAY DIFFRACTION' ? 0.0047  ? 802  ? f_plane_restr      ? ? 
'X-RAY DIFFRACTION' ? 15.0617 ? 1712 ? f_dihedral_angle_d ? ? 
# 
loop_
_refine_ls_shell.pdbx_refine_id 
_refine_ls_shell.d_res_high 
_refine_ls_shell.d_res_low 
_refine_ls_shell.number_reflns_all 
_refine_ls_shell.number_reflns_obs 
_refine_ls_shell.number_reflns_R_free 
_refine_ls_shell.number_reflns_R_work 
_refine_ls_shell.percent_reflns_obs 
_refine_ls_shell.percent_reflns_R_free 
_refine_ls_shell.R_factor_all 
_refine_ls_shell.R_factor_obs 
_refine_ls_shell.R_factor_R_free_error 
_refine_ls_shell.R_factor_R_work 
_refine_ls_shell.redundancy_reflns_all 
_refine_ls_shell.redundancy_reflns_obs 
_refine_ls_shell.wR_factor_all 
_refine_ls_shell.wR_factor_obs 
_refine_ls_shell.wR_factor_R_free 
_refine_ls_shell.wR_factor_R_work 
_refine_ls_shell.pdbx_R_complete 
_refine_ls_shell.pdbx_total_number_of_bins_used 
_refine_ls_shell.pdbx_phase_error 
_refine_ls_shell.pdbx_fsc_work 
_refine_ls_shell.pdbx_fsc_free 
_refine_ls_shell.R_factor_R_free 
'X-RAY DIFFRACTION' 2.52 2.63  . . 189 2625 99.29 . . . . 0.4122 . . . . . . . . . . . 0.5232 
'X-RAY DIFFRACTION' 2.63 2.77  . . 134 2759 99.72 . . . . 0.3793 . . . . . . . . . . . 0.3937 
'X-RAY DIFFRACTION' 2.77 2.95  . . 127 2715 99.47 . . . . 0.3662 . . . . . . . . . . . 0.4230 
'X-RAY DIFFRACTION' 2.95 3.17  . . 129 2733 98.62 . . . . 0.3221 . . . . . . . . . . . 0.3770 
'X-RAY DIFFRACTION' 3.17 3.49  . . 146 2715 98.83 . . . . 0.2993 . . . . . . . . . . . 0.3357 
'X-RAY DIFFRACTION' 3.49 4.00  . . 144 2734 99.14 . . . . 0.2614 . . . . . . . . . . . 0.2628 
'X-RAY DIFFRACTION' 4.00 5.03  . . 145 2824 99.73 . . . . 0.2159 . . . . . . . . . . . 0.2388 
'X-RAY DIFFRACTION' 5.04 55.23 . . 139 2930 99.51 . . . . 0.1984 . . . . . . . . . . . 0.2386 
# 
_struct.entry_id                     9IAC 
_struct.title                        
'Structure of the Argonaute-associated Cas4 family protein 1 (ACE1) from Microcystis aeruginosa (MaACE1)' 
_struct.pdbx_model_details           ? 
_struct.pdbx_formula_weight          ? 
_struct.pdbx_formula_weight_method   ? 
_struct.pdbx_model_type_details      ? 
_struct.pdbx_CASP_flag               N 
# 
_struct_keywords.entry_id        9IAC 
_struct_keywords.text            'Cas4 family protein, IMMUNE SYSTEM, deoxyribonuclease, hydrolase' 
_struct_keywords.pdbx_keywords   'IMMUNE SYSTEM' 
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 1 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 4 ? 
H N N 2 ? 
I N N 4 ? 
J N N 3 ? 
K N N 4 ? 
L N N 4 ? 
M N N 5 ? 
N N N 5 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    A8YDH4_MICA7 
_struct_ref.pdbx_db_accession          A8YDH4 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;SCQSPKKPWYPPMSYSLWRSLKPAIGYENWHCQTKRGFEKARNKEPEVQRLLSEDNQPQKIGKLAQRGVFEFHQELVRLS
GSHGVEQVAEILQLNQESPEIQARVLVILNNYYQQPILLNKEIINLSRGDEGYPEPIVIEQGNYKFNLSAAFDCIFREAD
DTIHILDLKTGQSNFDRRQAHVYLLAASYRYPQEKIVASFYNLETQTSSEKISLSSEAIEAVKIELASLAKKHQQQLQKY
KDHPKDFYHIFPPQSGYVCRYCPFTSICDYANKEV
;
_struct_ref.pdbx_align_begin           2 
# 
loop_
_struct_ref_seq.align_id 
_struct_ref_seq.ref_id 
_struct_ref_seq.pdbx_PDB_id_code 
_struct_ref_seq.pdbx_strand_id 
_struct_ref_seq.seq_align_beg 
_struct_ref_seq.pdbx_seq_align_beg_ins_code 
_struct_ref_seq.seq_align_end 
_struct_ref_seq.pdbx_seq_align_end_ins_code 
_struct_ref_seq.pdbx_db_accession 
_struct_ref_seq.db_align_beg 
_struct_ref_seq.pdbx_db_align_beg_ins_code 
_struct_ref_seq.db_align_end 
_struct_ref_seq.pdbx_db_align_end_ins_code 
_struct_ref_seq.pdbx_auth_seq_align_beg 
_struct_ref_seq.pdbx_auth_seq_align_end 
1 1 9IAC A 3 ? 277 ? A8YDH4 2 ? 276 ? 2 276 
2 1 9IAC B 3 ? 277 ? A8YDH4 2 ? 276 ? 2 276 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 9IAC SER A 1 ? UNP A8YDH4 ? ? 'expression tag' 0 1 
1 9IAC ALA A 2 ? UNP A8YDH4 ? ? 'expression tag' 1 2 
2 9IAC SER B 1 ? UNP A8YDH4 ? ? 'expression tag' 0 3 
2 9IAC ALA B 2 ? UNP A8YDH4 ? ? 'expression tag' 1 4 
# 
loop_
_pdbx_struct_assembly.id 
_pdbx_struct_assembly.details 
_pdbx_struct_assembly.method_details 
_pdbx_struct_assembly.oligomeric_details 
_pdbx_struct_assembly.oligomeric_count 
1 author_defined_assembly ? monomeric 1 
2 author_defined_assembly ? monomeric 1 
# 
loop_
_pdbx_struct_assembly_gen.assembly_id 
_pdbx_struct_assembly_gen.oper_expression 
_pdbx_struct_assembly_gen.asym_id_list 
1 1 A,C,D,E,F,G,M 
2 1 B,H,I,J,K,L,N 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 SER A 16  ? LYS A 24  ? SER A 15  LYS A 23  1 ? 9  
HELX_P HELX_P2  AA2 TYR A 29  ? HIS A 33  ? TYR A 28  HIS A 32  5 ? 5  
HELX_P HELX_P3  AA3 CYS A 34  ? LYS A 42  ? CYS A 33  LYS A 41  1 ? 9  
HELX_P HELX_P4  AA4 GLU A 47  ? LEU A 54  ? GLU A 46  LEU A 53  1 ? 8  
HELX_P HELX_P5  AA5 ASN A 58  ? GLU A 77  ? ASN A 57  GLU A 76  1 ? 20 
HELX_P HELX_P6  AA6 LEU A 78  ? GLY A 83  ? LEU A 77  GLY A 82  1 ? 6  
HELX_P HELX_P7  AA7 HIS A 85  ? LEU A 94  ? HIS A 84  LEU A 93  1 ? 10 
HELX_P HELX_P8  AA8 GLN A 95  ? GLU A 99  ? GLN A 94  GLU A 98  5 ? 5  
HELX_P HELX_P9  AA9 SER A 100 ? GLN A 117 ? SER A 99  GLN A 116 1 ? 18 
HELX_P HELX_P10 AB1 ASP A 178 ? TYR A 191 ? ASP A 177 TYR A 190 1 ? 14 
HELX_P HELX_P11 AB2 SER A 217 ? HIS A 245 ? SER A 216 HIS A 244 1 ? 29 
HELX_P HELX_P12 AB3 ASP A 248 ? PHE A 253 ? ASP A 247 PHE A 252 1 ? 6  
HELX_P HELX_P13 AB4 GLY A 258 ? TYR A 263 ? GLY A 257 TYR A 262 5 ? 6  
HELX_P HELX_P14 AB5 SER B 16  ? LYS B 24  ? SER B 15  LYS B 23  1 ? 9  
HELX_P HELX_P15 AB6 TYR B 29  ? HIS B 33  ? TYR B 28  HIS B 32  5 ? 5  
HELX_P HELX_P16 AB7 CYS B 34  ? ALA B 43  ? CYS B 33  ALA B 42  1 ? 10 
HELX_P HELX_P17 AB8 GLU B 47  ? GLU B 56  ? GLU B 46  GLU B 55  1 ? 10 
HELX_P HELX_P18 AB9 ASN B 58  ? GLU B 77  ? ASN B 57  GLU B 76  1 ? 20 
HELX_P HELX_P19 AC1 LEU B 78  ? GLY B 83  ? LEU B 77  GLY B 82  1 ? 6  
HELX_P HELX_P20 AC2 HIS B 85  ? LEU B 94  ? HIS B 84  LEU B 93  1 ? 10 
HELX_P HELX_P21 AC3 GLN B 95  ? GLU B 99  ? GLN B 94  GLU B 98  5 ? 5  
HELX_P HELX_P22 AC4 SER B 100 ? GLN B 117 ? SER B 99  GLN B 116 1 ? 18 
HELX_P HELX_P23 AC5 ASP B 178 ? SER B 190 ? ASP B 177 SER B 189 1 ? 13 
HELX_P HELX_P24 AC6 SER B 217 ? HIS B 245 ? SER B 216 HIS B 244 1 ? 29 
HELX_P HELX_P25 AC7 ASP B 248 ? PHE B 253 ? ASP B 247 PHE B 252 1 ? 6  
HELX_P HELX_P26 AC8 TYR B 259 ? CYS B 264 ? TYR B 258 CYS B 263 1 ? 6  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1  metalc ? ? A CYS 34  SG  ? ? ? 1_555 C SF4 . FE2 ? ? A CYS 33  A SF4 301 1_555 ? ? ? ? ? ? ? 2.207 ? ? 
metalc2  metalc ? ? A ASP 155 OD2 ? ? ? 1_555 D MG  . MG  ? ? A ASP 154 A MG  302 1_555 ? ? ? ? ? ? ? 2.120 ? ? 
metalc3  metalc ? ? A LEU 170 O   ? ? ? 1_555 D MG  . MG  ? ? A LEU 169 A MG  302 1_555 ? ? ? ? ? ? ? 2.198 ? ? 
metalc4  metalc ? ? A CYS 261 SG  ? ? ? 1_555 C SF4 . FE3 ? ? A CYS 260 A SF4 301 1_555 ? ? ? ? ? ? ? 2.171 ? ? 
metalc5  metalc ? ? A CYS 264 SG  ? ? ? 1_555 C SF4 . FE4 ? ? A CYS 263 A SF4 301 1_555 ? ? ? ? ? ? ? 2.309 ? ? 
metalc6  metalc ? ? A CYS 270 SG  ? ? ? 1_555 C SF4 . FE1 ? ? A CYS 269 A SF4 301 1_555 ? ? ? ? ? ? ? 2.205 ? ? 
metalc7  metalc ? ? D MG  .   MG  ? ? ? 1_555 M HOH . O   ? ? A MG  302 A HOH 404 1_555 ? ? ? ? ? ? ? 2.185 ? ? 
metalc8  metalc ? ? D MG  .   MG  ? ? ? 1_555 M HOH . O   ? ? A MG  302 A HOH 426 1_555 ? ? ? ? ? ? ? 2.881 ? ? 
metalc9  metalc ? ? B CYS 34  SG  ? ? ? 1_555 H SF4 . FE4 ? ? B CYS 33  B SF4 301 1_555 ? ? ? ? ? ? ? 2.269 ? ? 
metalc10 metalc ? ? B ASP 155 OD2 ? ? ? 1_555 J MG  . MG  ? ? B ASP 154 B MG  303 1_555 ? ? ? ? ? ? ? 2.522 ? ? 
metalc11 metalc ? ? B ASP 169 OD1 ? ? ? 1_555 J MG  . MG  ? ? B ASP 168 B MG  303 1_555 ? ? ? ? ? ? ? 2.961 ? ? 
metalc12 metalc ? ? B LEU 170 O   ? ? ? 1_555 J MG  . MG  ? ? B LEU 169 B MG  303 1_555 ? ? ? ? ? ? ? 2.764 ? ? 
metalc13 metalc ? ? B CYS 261 SG  ? ? ? 1_555 H SF4 . FE1 ? ? B CYS 260 B SF4 301 1_555 ? ? ? ? ? ? ? 2.239 ? ? 
metalc14 metalc ? ? B CYS 264 SG  ? ? ? 1_555 H SF4 . FE3 ? ? B CYS 263 B SF4 301 1_555 ? ? ? ? ? ? ? 2.159 ? ? 
metalc15 metalc ? ? B CYS 270 SG  ? ? ? 1_555 H SF4 . FE2 ? ? B CYS 269 B SF4 301 1_555 ? ? ? ? ? ? ? 2.252 ? ? 
metalc16 metalc ? ? J MG  .   MG  ? ? ? 1_555 N HOH . O   ? ? B MG  303 B HOH 401 1_555 ? ? ? ? ? ? ? 2.244 ? ? 
metalc17 metalc ? ? J MG  .   MG  ? ? ? 1_555 N HOH . O   ? ? B MG  303 B HOH 408 1_555 ? ? ? ? ? ? ? 2.583 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  SG  ? A CYS 34  ? A CYS 33  ? 1_555 FE2 ? C SF4 . ? A SF4 301 ? 1_555 S1  ? C SF4 .   ? A SF4 301 ? 1_555 118.8 ? 
2  SG  ? A CYS 34  ? A CYS 33  ? 1_555 FE2 ? C SF4 . ? A SF4 301 ? 1_555 S3  ? C SF4 .   ? A SF4 301 ? 1_555 118.7 ? 
3  S1  ? C SF4 .   ? A SF4 301 ? 1_555 FE2 ? C SF4 . ? A SF4 301 ? 1_555 S3  ? C SF4 .   ? A SF4 301 ? 1_555 104.4 ? 
4  SG  ? A CYS 34  ? A CYS 33  ? 1_555 FE2 ? C SF4 . ? A SF4 301 ? 1_555 S4  ? C SF4 .   ? A SF4 301 ? 1_555 104.3 ? 
5  S1  ? C SF4 .   ? A SF4 301 ? 1_555 FE2 ? C SF4 . ? A SF4 301 ? 1_555 S4  ? C SF4 .   ? A SF4 301 ? 1_555 104.4 ? 
6  S3  ? C SF4 .   ? A SF4 301 ? 1_555 FE2 ? C SF4 . ? A SF4 301 ? 1_555 S4  ? C SF4 .   ? A SF4 301 ? 1_555 104.4 ? 
7  OD2 ? A ASP 155 ? A ASP 154 ? 1_555 MG  ? D MG  . ? A MG  302 ? 1_555 O   ? A LEU 170 ? A LEU 169 ? 1_555 101.5 ? 
8  OD2 ? A ASP 155 ? A ASP 154 ? 1_555 MG  ? D MG  . ? A MG  302 ? 1_555 O   ? M HOH .   ? A HOH 404 ? 1_555 88.0  ? 
9  O   ? A LEU 170 ? A LEU 169 ? 1_555 MG  ? D MG  . ? A MG  302 ? 1_555 O   ? M HOH .   ? A HOH 404 ? 1_555 92.4  ? 
10 OD2 ? A ASP 155 ? A ASP 154 ? 1_555 MG  ? D MG  . ? A MG  302 ? 1_555 O   ? M HOH .   ? A HOH 426 ? 1_555 94.3  ? 
11 O   ? A LEU 170 ? A LEU 169 ? 1_555 MG  ? D MG  . ? A MG  302 ? 1_555 O   ? M HOH .   ? A HOH 426 ? 1_555 139.5 ? 
12 O   ? M HOH .   ? A HOH 404 ? 1_555 MG  ? D MG  . ? A MG  302 ? 1_555 O   ? M HOH .   ? A HOH 426 ? 1_555 125.5 ? 
13 SG  ? A CYS 261 ? A CYS 260 ? 1_555 FE3 ? C SF4 . ? A SF4 301 ? 1_555 S1  ? C SF4 .   ? A SF4 301 ? 1_555 113.4 ? 
14 SG  ? A CYS 261 ? A CYS 260 ? 1_555 FE3 ? C SF4 . ? A SF4 301 ? 1_555 S2  ? C SF4 .   ? A SF4 301 ? 1_555 126.2 ? 
15 S1  ? C SF4 .   ? A SF4 301 ? 1_555 FE3 ? C SF4 . ? A SF4 301 ? 1_555 S2  ? C SF4 .   ? A SF4 301 ? 1_555 104.5 ? 
16 SG  ? A CYS 261 ? A CYS 260 ? 1_555 FE3 ? C SF4 . ? A SF4 301 ? 1_555 S4  ? C SF4 .   ? A SF4 301 ? 1_555 101.9 ? 
17 S1  ? C SF4 .   ? A SF4 301 ? 1_555 FE3 ? C SF4 . ? A SF4 301 ? 1_555 S4  ? C SF4 .   ? A SF4 301 ? 1_555 104.2 ? 
18 S2  ? C SF4 .   ? A SF4 301 ? 1_555 FE3 ? C SF4 . ? A SF4 301 ? 1_555 S4  ? C SF4 .   ? A SF4 301 ? 1_555 104.2 ? 
19 SG  ? A CYS 264 ? A CYS 263 ? 1_555 FE4 ? C SF4 . ? A SF4 301 ? 1_555 S1  ? C SF4 .   ? A SF4 301 ? 1_555 115.0 ? 
20 SG  ? A CYS 264 ? A CYS 263 ? 1_555 FE4 ? C SF4 . ? A SF4 301 ? 1_555 S2  ? C SF4 .   ? A SF4 301 ? 1_555 119.6 ? 
21 S1  ? C SF4 .   ? A SF4 301 ? 1_555 FE4 ? C SF4 . ? A SF4 301 ? 1_555 S2  ? C SF4 .   ? A SF4 301 ? 1_555 104.6 ? 
22 SG  ? A CYS 264 ? A CYS 263 ? 1_555 FE4 ? C SF4 . ? A SF4 301 ? 1_555 S3  ? C SF4 .   ? A SF4 301 ? 1_555 107.4 ? 
23 S1  ? C SF4 .   ? A SF4 301 ? 1_555 FE4 ? C SF4 . ? A SF4 301 ? 1_555 S3  ? C SF4 .   ? A SF4 301 ? 1_555 104.2 ? 
24 S2  ? C SF4 .   ? A SF4 301 ? 1_555 FE4 ? C SF4 . ? A SF4 301 ? 1_555 S3  ? C SF4 .   ? A SF4 301 ? 1_555 104.4 ? 
25 SG  ? A CYS 270 ? A CYS 269 ? 1_555 FE1 ? C SF4 . ? A SF4 301 ? 1_555 S2  ? C SF4 .   ? A SF4 301 ? 1_555 122.9 ? 
26 SG  ? A CYS 270 ? A CYS 269 ? 1_555 FE1 ? C SF4 . ? A SF4 301 ? 1_555 S3  ? C SF4 .   ? A SF4 301 ? 1_555 108.4 ? 
27 S2  ? C SF4 .   ? A SF4 301 ? 1_555 FE1 ? C SF4 . ? A SF4 301 ? 1_555 S3  ? C SF4 .   ? A SF4 301 ? 1_555 104.4 ? 
28 SG  ? A CYS 270 ? A CYS 269 ? 1_555 FE1 ? C SF4 . ? A SF4 301 ? 1_555 S4  ? C SF4 .   ? A SF4 301 ? 1_555 110.7 ? 
29 S2  ? C SF4 .   ? A SF4 301 ? 1_555 FE1 ? C SF4 . ? A SF4 301 ? 1_555 S4  ? C SF4 .   ? A SF4 301 ? 1_555 104.4 ? 
30 S3  ? C SF4 .   ? A SF4 301 ? 1_555 FE1 ? C SF4 . ? A SF4 301 ? 1_555 S4  ? C SF4 .   ? A SF4 301 ? 1_555 104.5 ? 
31 SG  ? B CYS 34  ? B CYS 33  ? 1_555 FE4 ? H SF4 . ? B SF4 301 ? 1_555 S1  ? H SF4 .   ? B SF4 301 ? 1_555 113.5 ? 
32 SG  ? B CYS 34  ? B CYS 33  ? 1_555 FE4 ? H SF4 . ? B SF4 301 ? 1_555 S2  ? H SF4 .   ? B SF4 301 ? 1_555 117.6 ? 
33 S1  ? H SF4 .   ? B SF4 301 ? 1_555 FE4 ? H SF4 . ? B SF4 301 ? 1_555 S2  ? H SF4 .   ? B SF4 301 ? 1_555 104.5 ? 
34 SG  ? B CYS 34  ? B CYS 33  ? 1_555 FE4 ? H SF4 . ? B SF4 301 ? 1_555 S3  ? H SF4 .   ? B SF4 301 ? 1_555 111.1 ? 
35 S1  ? H SF4 .   ? B SF4 301 ? 1_555 FE4 ? H SF4 . ? B SF4 301 ? 1_555 S3  ? H SF4 .   ? B SF4 301 ? 1_555 104.4 ? 
36 S2  ? H SF4 .   ? B SF4 301 ? 1_555 FE4 ? H SF4 . ? B SF4 301 ? 1_555 S3  ? H SF4 .   ? B SF4 301 ? 1_555 104.6 ? 
37 OD2 ? B ASP 155 ? B ASP 154 ? 1_555 MG  ? J MG  . ? B MG  303 ? 1_555 OD1 ? B ASP 169 ? B ASP 168 ? 1_555 69.9  ? 
38 OD2 ? B ASP 155 ? B ASP 154 ? 1_555 MG  ? J MG  . ? B MG  303 ? 1_555 O   ? B LEU 170 ? B LEU 169 ? 1_555 71.0  ? 
39 OD1 ? B ASP 169 ? B ASP 168 ? 1_555 MG  ? J MG  . ? B MG  303 ? 1_555 O   ? B LEU 170 ? B LEU 169 ? 1_555 95.4  ? 
40 OD2 ? B ASP 155 ? B ASP 154 ? 1_555 MG  ? J MG  . ? B MG  303 ? 1_555 O   ? N HOH .   ? B HOH 401 ? 1_555 55.4  ? 
41 OD1 ? B ASP 169 ? B ASP 168 ? 1_555 MG  ? J MG  . ? B MG  303 ? 1_555 O   ? N HOH .   ? B HOH 401 ? 1_555 122.6 ? 
42 O   ? B LEU 170 ? B LEU 169 ? 1_555 MG  ? J MG  . ? B MG  303 ? 1_555 O   ? N HOH .   ? B HOH 401 ? 1_555 53.7  ? 
43 OD2 ? B ASP 155 ? B ASP 154 ? 1_555 MG  ? J MG  . ? B MG  303 ? 1_555 O   ? N HOH .   ? B HOH 408 ? 1_555 68.9  ? 
44 OD1 ? B ASP 169 ? B ASP 168 ? 1_555 MG  ? J MG  . ? B MG  303 ? 1_555 O   ? N HOH .   ? B HOH 408 ? 1_555 108.2 ? 
45 O   ? B LEU 170 ? B LEU 169 ? 1_555 MG  ? J MG  . ? B MG  303 ? 1_555 O   ? N HOH .   ? B HOH 408 ? 1_555 121.6 ? 
46 O   ? N HOH .   ? B HOH 401 ? 1_555 MG  ? J MG  . ? B MG  303 ? 1_555 O   ? N HOH .   ? B HOH 408 ? 1_555 68.9  ? 
47 SG  ? B CYS 261 ? B CYS 260 ? 1_555 FE1 ? H SF4 . ? B SF4 301 ? 1_555 S2  ? H SF4 .   ? B SF4 301 ? 1_555 117.0 ? 
48 SG  ? B CYS 261 ? B CYS 260 ? 1_555 FE1 ? H SF4 . ? B SF4 301 ? 1_555 S3  ? H SF4 .   ? B SF4 301 ? 1_555 120.2 ? 
49 S2  ? H SF4 .   ? B SF4 301 ? 1_555 FE1 ? H SF4 . ? B SF4 301 ? 1_555 S3  ? H SF4 .   ? B SF4 301 ? 1_555 104.6 ? 
50 SG  ? B CYS 261 ? B CYS 260 ? 1_555 FE1 ? H SF4 . ? B SF4 301 ? 1_555 S4  ? H SF4 .   ? B SF4 301 ? 1_555 104.6 ? 
51 S2  ? H SF4 .   ? B SF4 301 ? 1_555 FE1 ? H SF4 . ? B SF4 301 ? 1_555 S4  ? H SF4 .   ? B SF4 301 ? 1_555 104.3 ? 
52 S3  ? H SF4 .   ? B SF4 301 ? 1_555 FE1 ? H SF4 . ? B SF4 301 ? 1_555 S4  ? H SF4 .   ? B SF4 301 ? 1_555 104.3 ? 
53 SG  ? B CYS 264 ? B CYS 263 ? 1_555 FE3 ? H SF4 . ? B SF4 301 ? 1_555 S1  ? H SF4 .   ? B SF4 301 ? 1_555 118.2 ? 
54 SG  ? B CYS 264 ? B CYS 263 ? 1_555 FE3 ? H SF4 . ? B SF4 301 ? 1_555 S2  ? H SF4 .   ? B SF4 301 ? 1_555 104.1 ? 
55 S1  ? H SF4 .   ? B SF4 301 ? 1_555 FE3 ? H SF4 . ? B SF4 301 ? 1_555 S2  ? H SF4 .   ? B SF4 301 ? 1_555 104.5 ? 
56 SG  ? B CYS 264 ? B CYS 263 ? 1_555 FE3 ? H SF4 . ? B SF4 301 ? 1_555 S4  ? H SF4 .   ? B SF4 301 ? 1_555 119.4 ? 
57 S1  ? H SF4 .   ? B SF4 301 ? 1_555 FE3 ? H SF4 . ? B SF4 301 ? 1_555 S4  ? H SF4 .   ? B SF4 301 ? 1_555 104.6 ? 
58 S2  ? H SF4 .   ? B SF4 301 ? 1_555 FE3 ? H SF4 . ? B SF4 301 ? 1_555 S4  ? H SF4 .   ? B SF4 301 ? 1_555 104.3 ? 
59 SG  ? B CYS 270 ? B CYS 269 ? 1_555 FE2 ? H SF4 . ? B SF4 301 ? 1_555 S1  ? H SF4 .   ? B SF4 301 ? 1_555 108.6 ? 
60 SG  ? B CYS 270 ? B CYS 269 ? 1_555 FE2 ? H SF4 . ? B SF4 301 ? 1_555 S3  ? H SF4 .   ? B SF4 301 ? 1_555 110.9 ? 
61 S1  ? H SF4 .   ? B SF4 301 ? 1_555 FE2 ? H SF4 . ? B SF4 301 ? 1_555 S3  ? H SF4 .   ? B SF4 301 ? 1_555 104.2 ? 
62 SG  ? B CYS 270 ? B CYS 269 ? 1_555 FE2 ? H SF4 . ? B SF4 301 ? 1_555 S4  ? H SF4 .   ? B SF4 301 ? 1_555 122.9 ? 
63 S1  ? H SF4 .   ? B SF4 301 ? 1_555 FE2 ? H SF4 . ? B SF4 301 ? 1_555 S4  ? H SF4 .   ? B SF4 301 ? 1_555 104.3 ? 
64 S3  ? H SF4 .   ? B SF4 301 ? 1_555 FE2 ? H SF4 . ? B SF4 301 ? 1_555 S4  ? H SF4 .   ? B SF4 301 ? 1_555 104.3 ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 3 ? 
AA2 ? 5 ? 
AA3 ? 3 ? 
AA4 ? 5 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? parallel      
AA1 2 3 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA2 2 3 ? anti-parallel 
AA2 3 4 ? parallel      
AA2 4 5 ? anti-parallel 
AA3 1 2 ? parallel      
AA3 2 3 ? anti-parallel 
AA4 1 2 ? anti-parallel 
AA4 2 3 ? anti-parallel 
AA4 3 4 ? parallel      
AA4 4 5 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 PRO A 14  ? MET A 15  ? PRO A 13  MET A 14  
AA1 2 TYR A 146 ? LEU A 150 ? TYR A 145 LEU A 149 
AA1 3 ILE A 139 ? GLN A 143 ? ILE A 138 GLN A 142 
AA2 1 GLU A 124 ? LEU A 128 ? GLU A 123 LEU A 127 
AA2 2 CYS A 156 ? ARG A 159 ? CYS A 155 ARG A 158 
AA2 3 ILE A 165 ? LYS A 171 ? ILE A 164 LYS A 170 
AA2 4 ILE A 198 ? ASN A 204 ? ILE A 197 ASN A 203 
AA2 5 THR A 209 ? SER A 210 ? THR A 208 SER A 209 
AA3 1 PRO B 14  ? MET B 15  ? PRO B 13  MET B 14  
AA3 2 TYR B 146 ? LEU B 150 ? TYR B 145 LEU B 149 
AA3 3 ILE B 139 ? GLN B 143 ? ILE B 138 GLN B 142 
AA4 1 GLU B 124 ? LEU B 128 ? GLU B 123 LEU B 127 
AA4 2 CYS B 156 ? ARG B 159 ? CYS B 155 ARG B 158 
AA4 3 ILE B 165 ? LYS B 171 ? ILE B 164 LYS B 170 
AA4 4 ILE B 198 ? ASN B 204 ? ILE B 197 ASN B 203 
AA4 5 THR B 209 ? SER B 210 ? THR B 208 SER B 209 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N MET A 15  ? N MET A 14  O ASN A 149 ? O ASN A 148 
AA1 2 3 O LEU A 150 ? O LEU A 149 N ILE A 139 ? N ILE A 138 
AA2 1 2 N ASN A 127 ? N ASN A 126 O ILE A 157 ? O ILE A 156 
AA2 2 3 N PHE A 158 ? N PHE A 157 O HIS A 166 ? O HIS A 165 
AA2 3 4 N ILE A 165 ? N ILE A 164 O VAL A 199 ? O VAL A 198 
AA2 4 5 N ASN A 204 ? N ASN A 203 O THR A 209 ? O THR A 208 
AA3 1 2 N MET B 15  ? N MET B 14  O ASN B 149 ? O ASN B 148 
AA3 2 3 O LEU B 150 ? O LEU B 149 N ILE B 139 ? N ILE B 138 
AA4 1 2 N ASN B 127 ? N ASN B 126 O ILE B 157 ? O ILE B 156 
AA4 2 3 N PHE B 158 ? N PHE B 157 O HIS B 166 ? O HIS B 165 
AA4 3 4 N ILE B 165 ? N ILE B 164 O VAL B 199 ? O VAL B 198 
AA4 4 5 N ASN B 204 ? N ASN B 203 O THR B 209 ? O THR B 208 
# 
_pdbx_entry_details.entry_id                   9IAC 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.has_ligand_of_interest     N 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ALA A 42  ? ? 72.40  -12.96  
2 1 PRO A 135 ? ? -69.97 -176.33 
# 
loop_
_space_group_symop.id 
_space_group_symop.operation_xyz 
1 x,y,z           
2 x+1/2,-y+1/2,-z 
3 -x,y+1/2,-z+1/2 
4 -x+1/2,-y,z+1/2 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A SER 0   ? A SER 1   
2  1 Y 1 A ALA 1   ? A ALA 2   
3  1 Y 1 A SER 2   ? A SER 3   
4  1 Y 1 A CYS 3   ? A CYS 4   
5  1 Y 1 A GLN 4   ? A GLN 5   
6  1 Y 1 A SER 5   ? A SER 6   
7  1 Y 1 A PRO 6   ? A PRO 7   
8  1 Y 1 A LYS 7   ? A LYS 8   
9  1 Y 1 A VAL 276 ? A VAL 277 
10 1 Y 1 B SER 0   ? B SER 1   
11 1 Y 1 B ALA 1   ? B ALA 2   
12 1 Y 1 B SER 2   ? B SER 3   
13 1 Y 1 B CYS 3   ? B CYS 4   
14 1 Y 1 B GLN 4   ? B GLN 5   
15 1 Y 1 B SER 5   ? B SER 6   
16 1 Y 1 B PRO 6   ? B PRO 7   
17 1 Y 1 B VAL 276 ? B VAL 277 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
EDO C1   C  N N 88  
EDO O1   O  N N 89  
EDO C2   C  N N 90  
EDO O2   O  N N 91  
EDO H11  H  N N 92  
EDO H12  H  N N 93  
EDO HO1  H  N N 94  
EDO H21  H  N N 95  
EDO H22  H  N N 96  
EDO HO2  H  N N 97  
GLN N    N  N N 98  
GLN CA   C  N S 99  
GLN C    C  N N 100 
GLN O    O  N N 101 
GLN CB   C  N N 102 
GLN CG   C  N N 103 
GLN CD   C  N N 104 
GLN OE1  O  N N 105 
GLN NE2  N  N N 106 
GLN OXT  O  N N 107 
GLN H    H  N N 108 
GLN H2   H  N N 109 
GLN HA   H  N N 110 
GLN HB2  H  N N 111 
GLN HB3  H  N N 112 
GLN HG2  H  N N 113 
GLN HG3  H  N N 114 
GLN HE21 H  N N 115 
GLN HE22 H  N N 116 
GLN HXT  H  N N 117 
GLU N    N  N N 118 
GLU CA   C  N S 119 
GLU C    C  N N 120 
GLU O    O  N N 121 
GLU CB   C  N N 122 
GLU CG   C  N N 123 
GLU CD   C  N N 124 
GLU OE1  O  N N 125 
GLU OE2  O  N N 126 
GLU OXT  O  N N 127 
GLU H    H  N N 128 
GLU H2   H  N N 129 
GLU HA   H  N N 130 
GLU HB2  H  N N 131 
GLU HB3  H  N N 132 
GLU HG2  H  N N 133 
GLU HG3  H  N N 134 
GLU HE2  H  N N 135 
GLU HXT  H  N N 136 
GLY N    N  N N 137 
GLY CA   C  N N 138 
GLY C    C  N N 139 
GLY O    O  N N 140 
GLY OXT  O  N N 141 
GLY H    H  N N 142 
GLY H2   H  N N 143 
GLY HA2  H  N N 144 
GLY HA3  H  N N 145 
GLY HXT  H  N N 146 
HIS N    N  N N 147 
HIS CA   C  N S 148 
HIS C    C  N N 149 
HIS O    O  N N 150 
HIS CB   C  N N 151 
HIS CG   C  Y N 152 
HIS ND1  N  Y N 153 
HIS CD2  C  Y N 154 
HIS CE1  C  Y N 155 
HIS NE2  N  Y N 156 
HIS OXT  O  N N 157 
HIS H    H  N N 158 
HIS H2   H  N N 159 
HIS HA   H  N N 160 
HIS HB2  H  N N 161 
HIS HB3  H  N N 162 
HIS HD1  H  N N 163 
HIS HD2  H  N N 164 
HIS HE1  H  N N 165 
HIS HE2  H  N N 166 
HIS HXT  H  N N 167 
HOH O    O  N N 168 
HOH H1   H  N N 169 
HOH H2   H  N N 170 
ILE N    N  N N 171 
ILE CA   C  N S 172 
ILE C    C  N N 173 
ILE O    O  N N 174 
ILE CB   C  N S 175 
ILE CG1  C  N N 176 
ILE CG2  C  N N 177 
ILE CD1  C  N N 178 
ILE OXT  O  N N 179 
ILE H    H  N N 180 
ILE H2   H  N N 181 
ILE HA   H  N N 182 
ILE HB   H  N N 183 
ILE HG12 H  N N 184 
ILE HG13 H  N N 185 
ILE HG21 H  N N 186 
ILE HG22 H  N N 187 
ILE HG23 H  N N 188 
ILE HD11 H  N N 189 
ILE HD12 H  N N 190 
ILE HD13 H  N N 191 
ILE HXT  H  N N 192 
LEU N    N  N N 193 
LEU CA   C  N S 194 
LEU C    C  N N 195 
LEU O    O  N N 196 
LEU CB   C  N N 197 
LEU CG   C  N N 198 
LEU CD1  C  N N 199 
LEU CD2  C  N N 200 
LEU OXT  O  N N 201 
LEU H    H  N N 202 
LEU H2   H  N N 203 
LEU HA   H  N N 204 
LEU HB2  H  N N 205 
LEU HB3  H  N N 206 
LEU HG   H  N N 207 
LEU HD11 H  N N 208 
LEU HD12 H  N N 209 
LEU HD13 H  N N 210 
LEU HD21 H  N N 211 
LEU HD22 H  N N 212 
LEU HD23 H  N N 213 
LEU HXT  H  N N 214 
LYS N    N  N N 215 
LYS CA   C  N S 216 
LYS C    C  N N 217 
LYS O    O  N N 218 
LYS CB   C  N N 219 
LYS CG   C  N N 220 
LYS CD   C  N N 221 
LYS CE   C  N N 222 
LYS NZ   N  N N 223 
LYS OXT  O  N N 224 
LYS H    H  N N 225 
LYS H2   H  N N 226 
LYS HA   H  N N 227 
LYS HB2  H  N N 228 
LYS HB3  H  N N 229 
LYS HG2  H  N N 230 
LYS HG3  H  N N 231 
LYS HD2  H  N N 232 
LYS HD3  H  N N 233 
LYS HE2  H  N N 234 
LYS HE3  H  N N 235 
LYS HZ1  H  N N 236 
LYS HZ2  H  N N 237 
LYS HZ3  H  N N 238 
LYS HXT  H  N N 239 
MET N    N  N N 240 
MET CA   C  N S 241 
MET C    C  N N 242 
MET O    O  N N 243 
MET CB   C  N N 244 
MET CG   C  N N 245 
MET SD   S  N N 246 
MET CE   C  N N 247 
MET OXT  O  N N 248 
MET H    H  N N 249 
MET H2   H  N N 250 
MET HA   H  N N 251 
MET HB2  H  N N 252 
MET HB3  H  N N 253 
MET HG2  H  N N 254 
MET HG3  H  N N 255 
MET HE1  H  N N 256 
MET HE2  H  N N 257 
MET HE3  H  N N 258 
MET HXT  H  N N 259 
MG  MG   MG N N 260 
PHE N    N  N N 261 
PHE CA   C  N S 262 
PHE C    C  N N 263 
PHE O    O  N N 264 
PHE CB   C  N N 265 
PHE CG   C  Y N 266 
PHE CD1  C  Y N 267 
PHE CD2  C  Y N 268 
PHE CE1  C  Y N 269 
PHE CE2  C  Y N 270 
PHE CZ   C  Y N 271 
PHE OXT  O  N N 272 
PHE H    H  N N 273 
PHE H2   H  N N 274 
PHE HA   H  N N 275 
PHE HB2  H  N N 276 
PHE HB3  H  N N 277 
PHE HD1  H  N N 278 
PHE HD2  H  N N 279 
PHE HE1  H  N N 280 
PHE HE2  H  N N 281 
PHE HZ   H  N N 282 
PHE HXT  H  N N 283 
PRO N    N  N N 284 
PRO CA   C  N S 285 
PRO C    C  N N 286 
PRO O    O  N N 287 
PRO CB   C  N N 288 
PRO CG   C  N N 289 
PRO CD   C  N N 290 
PRO OXT  O  N N 291 
PRO H    H  N N 292 
PRO HA   H  N N 293 
PRO HB2  H  N N 294 
PRO HB3  H  N N 295 
PRO HG2  H  N N 296 
PRO HG3  H  N N 297 
PRO HD2  H  N N 298 
PRO HD3  H  N N 299 
PRO HXT  H  N N 300 
SER N    N  N N 301 
SER CA   C  N S 302 
SER C    C  N N 303 
SER O    O  N N 304 
SER CB   C  N N 305 
SER OG   O  N N 306 
SER OXT  O  N N 307 
SER H    H  N N 308 
SER H2   H  N N 309 
SER HA   H  N N 310 
SER HB2  H  N N 311 
SER HB3  H  N N 312 
SER HG   H  N N 313 
SER HXT  H  N N 314 
SF4 FE1  FE N N 315 
SF4 FE2  FE N N 316 
SF4 FE3  FE N N 317 
SF4 FE4  FE N N 318 
SF4 S1   S  N N 319 
SF4 S2   S  N N 320 
SF4 S3   S  N N 321 
SF4 S4   S  N N 322 
THR N    N  N N 323 
THR CA   C  N S 324 
THR C    C  N N 325 
THR O    O  N N 326 
THR CB   C  N R 327 
THR OG1  O  N N 328 
THR CG2  C  N N 329 
THR OXT  O  N N 330 
THR H    H  N N 331 
THR H2   H  N N 332 
THR HA   H  N N 333 
THR HB   H  N N 334 
THR HG1  H  N N 335 
THR HG21 H  N N 336 
THR HG22 H  N N 337 
THR HG23 H  N N 338 
THR HXT  H  N N 339 
TRP N    N  N N 340 
TRP CA   C  N S 341 
TRP C    C  N N 342 
TRP O    O  N N 343 
TRP CB   C  N N 344 
TRP CG   C  Y N 345 
TRP CD1  C  Y N 346 
TRP CD2  C  Y N 347 
TRP NE1  N  Y N 348 
TRP CE2  C  Y N 349 
TRP CE3  C  Y N 350 
TRP CZ2  C  Y N 351 
TRP CZ3  C  Y N 352 
TRP CH2  C  Y N 353 
TRP OXT  O  N N 354 
TRP H    H  N N 355 
TRP H2   H  N N 356 
TRP HA   H  N N 357 
TRP HB2  H  N N 358 
TRP HB3  H  N N 359 
TRP HD1  H  N N 360 
TRP HE1  H  N N 361 
TRP HE3  H  N N 362 
TRP HZ2  H  N N 363 
TRP HZ3  H  N N 364 
TRP HH2  H  N N 365 
TRP HXT  H  N N 366 
TYR N    N  N N 367 
TYR CA   C  N S 368 
TYR C    C  N N 369 
TYR O    O  N N 370 
TYR CB   C  N N 371 
TYR CG   C  Y N 372 
TYR CD1  C  Y N 373 
TYR CD2  C  Y N 374 
TYR CE1  C  Y N 375 
TYR CE2  C  Y N 376 
TYR CZ   C  Y N 377 
TYR OH   O  N N 378 
TYR OXT  O  N N 379 
TYR H    H  N N 380 
TYR H2   H  N N 381 
TYR HA   H  N N 382 
TYR HB2  H  N N 383 
TYR HB3  H  N N 384 
TYR HD1  H  N N 385 
TYR HD2  H  N N 386 
TYR HE1  H  N N 387 
TYR HE2  H  N N 388 
TYR HH   H  N N 389 
TYR HXT  H  N N 390 
VAL N    N  N N 391 
VAL CA   C  N S 392 
VAL C    C  N N 393 
VAL O    O  N N 394 
VAL CB   C  N N 395 
VAL CG1  C  N N 396 
VAL CG2  C  N N 397 
VAL OXT  O  N N 398 
VAL H    H  N N 399 
VAL H2   H  N N 400 
VAL HA   H  N N 401 
VAL HB   H  N N 402 
VAL HG11 H  N N 403 
VAL HG12 H  N N 404 
VAL HG13 H  N N 405 
VAL HG21 H  N N 406 
VAL HG22 H  N N 407 
VAL HG23 H  N N 408 
VAL HXT  H  N N 409 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
EDO C1  O1   sing N N 83  
EDO C1  C2   sing N N 84  
EDO C1  H11  sing N N 85  
EDO C1  H12  sing N N 86  
EDO O1  HO1  sing N N 87  
EDO C2  O2   sing N N 88  
EDO C2  H21  sing N N 89  
EDO C2  H22  sing N N 90  
EDO O2  HO2  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
HIS N   CA   sing N N 138 
HIS N   H    sing N N 139 
HIS N   H2   sing N N 140 
HIS CA  C    sing N N 141 
HIS CA  CB   sing N N 142 
HIS CA  HA   sing N N 143 
HIS C   O    doub N N 144 
HIS C   OXT  sing N N 145 
HIS CB  CG   sing N N 146 
HIS CB  HB2  sing N N 147 
HIS CB  HB3  sing N N 148 
HIS CG  ND1  sing Y N 149 
HIS CG  CD2  doub Y N 150 
HIS ND1 CE1  doub Y N 151 
HIS ND1 HD1  sing N N 152 
HIS CD2 NE2  sing Y N 153 
HIS CD2 HD2  sing N N 154 
HIS CE1 NE2  sing Y N 155 
HIS CE1 HE1  sing N N 156 
HIS NE2 HE2  sing N N 157 
HIS OXT HXT  sing N N 158 
HOH O   H1   sing N N 159 
HOH O   H2   sing N N 160 
ILE N   CA   sing N N 161 
ILE N   H    sing N N 162 
ILE N   H2   sing N N 163 
ILE CA  C    sing N N 164 
ILE CA  CB   sing N N 165 
ILE CA  HA   sing N N 166 
ILE C   O    doub N N 167 
ILE C   OXT  sing N N 168 
ILE CB  CG1  sing N N 169 
ILE CB  CG2  sing N N 170 
ILE CB  HB   sing N N 171 
ILE CG1 CD1  sing N N 172 
ILE CG1 HG12 sing N N 173 
ILE CG1 HG13 sing N N 174 
ILE CG2 HG21 sing N N 175 
ILE CG2 HG22 sing N N 176 
ILE CG2 HG23 sing N N 177 
ILE CD1 HD11 sing N N 178 
ILE CD1 HD12 sing N N 179 
ILE CD1 HD13 sing N N 180 
ILE OXT HXT  sing N N 181 
LEU N   CA   sing N N 182 
LEU N   H    sing N N 183 
LEU N   H2   sing N N 184 
LEU CA  C    sing N N 185 
LEU CA  CB   sing N N 186 
LEU CA  HA   sing N N 187 
LEU C   O    doub N N 188 
LEU C   OXT  sing N N 189 
LEU CB  CG   sing N N 190 
LEU CB  HB2  sing N N 191 
LEU CB  HB3  sing N N 192 
LEU CG  CD1  sing N N 193 
LEU CG  CD2  sing N N 194 
LEU CG  HG   sing N N 195 
LEU CD1 HD11 sing N N 196 
LEU CD1 HD12 sing N N 197 
LEU CD1 HD13 sing N N 198 
LEU CD2 HD21 sing N N 199 
LEU CD2 HD22 sing N N 200 
LEU CD2 HD23 sing N N 201 
LEU OXT HXT  sing N N 202 
LYS N   CA   sing N N 203 
LYS N   H    sing N N 204 
LYS N   H2   sing N N 205 
LYS CA  C    sing N N 206 
LYS CA  CB   sing N N 207 
LYS CA  HA   sing N N 208 
LYS C   O    doub N N 209 
LYS C   OXT  sing N N 210 
LYS CB  CG   sing N N 211 
LYS CB  HB2  sing N N 212 
LYS CB  HB3  sing N N 213 
LYS CG  CD   sing N N 214 
LYS CG  HG2  sing N N 215 
LYS CG  HG3  sing N N 216 
LYS CD  CE   sing N N 217 
LYS CD  HD2  sing N N 218 
LYS CD  HD3  sing N N 219 
LYS CE  NZ   sing N N 220 
LYS CE  HE2  sing N N 221 
LYS CE  HE3  sing N N 222 
LYS NZ  HZ1  sing N N 223 
LYS NZ  HZ2  sing N N 224 
LYS NZ  HZ3  sing N N 225 
LYS OXT HXT  sing N N 226 
MET N   CA   sing N N 227 
MET N   H    sing N N 228 
MET N   H2   sing N N 229 
MET CA  C    sing N N 230 
MET CA  CB   sing N N 231 
MET CA  HA   sing N N 232 
MET C   O    doub N N 233 
MET C   OXT  sing N N 234 
MET CB  CG   sing N N 235 
MET CB  HB2  sing N N 236 
MET CB  HB3  sing N N 237 
MET CG  SD   sing N N 238 
MET CG  HG2  sing N N 239 
MET CG  HG3  sing N N 240 
MET SD  CE   sing N N 241 
MET CE  HE1  sing N N 242 
MET CE  HE2  sing N N 243 
MET CE  HE3  sing N N 244 
MET OXT HXT  sing N N 245 
PHE N   CA   sing N N 246 
PHE N   H    sing N N 247 
PHE N   H2   sing N N 248 
PHE CA  C    sing N N 249 
PHE CA  CB   sing N N 250 
PHE CA  HA   sing N N 251 
PHE C   O    doub N N 252 
PHE C   OXT  sing N N 253 
PHE CB  CG   sing N N 254 
PHE CB  HB2  sing N N 255 
PHE CB  HB3  sing N N 256 
PHE CG  CD1  doub Y N 257 
PHE CG  CD2  sing Y N 258 
PHE CD1 CE1  sing Y N 259 
PHE CD1 HD1  sing N N 260 
PHE CD2 CE2  doub Y N 261 
PHE CD2 HD2  sing N N 262 
PHE CE1 CZ   doub Y N 263 
PHE CE1 HE1  sing N N 264 
PHE CE2 CZ   sing Y N 265 
PHE CE2 HE2  sing N N 266 
PHE CZ  HZ   sing N N 267 
PHE OXT HXT  sing N N 268 
PRO N   CA   sing N N 269 
PRO N   CD   sing N N 270 
PRO N   H    sing N N 271 
PRO CA  C    sing N N 272 
PRO CA  CB   sing N N 273 
PRO CA  HA   sing N N 274 
PRO C   O    doub N N 275 
PRO C   OXT  sing N N 276 
PRO CB  CG   sing N N 277 
PRO CB  HB2  sing N N 278 
PRO CB  HB3  sing N N 279 
PRO CG  CD   sing N N 280 
PRO CG  HG2  sing N N 281 
PRO CG  HG3  sing N N 282 
PRO CD  HD2  sing N N 283 
PRO CD  HD3  sing N N 284 
PRO OXT HXT  sing N N 285 
SER N   CA   sing N N 286 
SER N   H    sing N N 287 
SER N   H2   sing N N 288 
SER CA  C    sing N N 289 
SER CA  CB   sing N N 290 
SER CA  HA   sing N N 291 
SER C   O    doub N N 292 
SER C   OXT  sing N N 293 
SER CB  OG   sing N N 294 
SER CB  HB2  sing N N 295 
SER CB  HB3  sing N N 296 
SER OG  HG   sing N N 297 
SER OXT HXT  sing N N 298 
SF4 FE1 S2   sing N N 299 
SF4 FE1 S3   sing N N 300 
SF4 FE1 S4   sing N N 301 
SF4 FE2 S1   sing N N 302 
SF4 FE2 S3   sing N N 303 
SF4 FE2 S4   sing N N 304 
SF4 FE3 S1   sing N N 305 
SF4 FE3 S2   sing N N 306 
SF4 FE3 S4   sing N N 307 
SF4 FE4 S1   sing N N 308 
SF4 FE4 S2   sing N N 309 
SF4 FE4 S3   sing N N 310 
THR N   CA   sing N N 311 
THR N   H    sing N N 312 
THR N   H2   sing N N 313 
THR CA  C    sing N N 314 
THR CA  CB   sing N N 315 
THR CA  HA   sing N N 316 
THR C   O    doub N N 317 
THR C   OXT  sing N N 318 
THR CB  OG1  sing N N 319 
THR CB  CG2  sing N N 320 
THR CB  HB   sing N N 321 
THR OG1 HG1  sing N N 322 
THR CG2 HG21 sing N N 323 
THR CG2 HG22 sing N N 324 
THR CG2 HG23 sing N N 325 
THR OXT HXT  sing N N 326 
TRP N   CA   sing N N 327 
TRP N   H    sing N N 328 
TRP N   H2   sing N N 329 
TRP CA  C    sing N N 330 
TRP CA  CB   sing N N 331 
TRP CA  HA   sing N N 332 
TRP C   O    doub N N 333 
TRP C   OXT  sing N N 334 
TRP CB  CG   sing N N 335 
TRP CB  HB2  sing N N 336 
TRP CB  HB3  sing N N 337 
TRP CG  CD1  doub Y N 338 
TRP CG  CD2  sing Y N 339 
TRP CD1 NE1  sing Y N 340 
TRP CD1 HD1  sing N N 341 
TRP CD2 CE2  doub Y N 342 
TRP CD2 CE3  sing Y N 343 
TRP NE1 CE2  sing Y N 344 
TRP NE1 HE1  sing N N 345 
TRP CE2 CZ2  sing Y N 346 
TRP CE3 CZ3  doub Y N 347 
TRP CE3 HE3  sing N N 348 
TRP CZ2 CH2  doub Y N 349 
TRP CZ2 HZ2  sing N N 350 
TRP CZ3 CH2  sing Y N 351 
TRP CZ3 HZ3  sing N N 352 
TRP CH2 HH2  sing N N 353 
TRP OXT HXT  sing N N 354 
TYR N   CA   sing N N 355 
TYR N   H    sing N N 356 
TYR N   H2   sing N N 357 
TYR CA  C    sing N N 358 
TYR CA  CB   sing N N 359 
TYR CA  HA   sing N N 360 
TYR C   O    doub N N 361 
TYR C   OXT  sing N N 362 
TYR CB  CG   sing N N 363 
TYR CB  HB2  sing N N 364 
TYR CB  HB3  sing N N 365 
TYR CG  CD1  doub Y N 366 
TYR CG  CD2  sing Y N 367 
TYR CD1 CE1  sing Y N 368 
TYR CD1 HD1  sing N N 369 
TYR CD2 CE2  doub Y N 370 
TYR CD2 HD2  sing N N 371 
TYR CE1 CZ   doub Y N 372 
TYR CE1 HE1  sing N N 373 
TYR CE2 CZ   sing Y N 374 
TYR CE2 HE2  sing N N 375 
TYR CZ  OH   sing N N 376 
TYR OH  HH   sing N N 377 
TYR OXT HXT  sing N N 378 
VAL N   CA   sing N N 379 
VAL N   H    sing N N 380 
VAL N   H2   sing N N 381 
VAL CA  C    sing N N 382 
VAL CA  CB   sing N N 383 
VAL CA  HA   sing N N 384 
VAL C   O    doub N N 385 
VAL C   OXT  sing N N 386 
VAL CB  CG1  sing N N 387 
VAL CB  CG2  sing N N 388 
VAL CB  HB   sing N N 389 
VAL CG1 HG11 sing N N 390 
VAL CG1 HG12 sing N N 391 
VAL CG1 HG13 sing N N 392 
VAL CG2 HG21 sing N N 393 
VAL CG2 HG22 sing N N 394 
VAL CG2 HG23 sing N N 395 
VAL OXT HXT  sing N N 396 
# 
loop_
_pdbx_audit_support.funding_organization 
_pdbx_audit_support.country 
_pdbx_audit_support.grant_number 
_pdbx_audit_support.ordinal 
'European Research Council (ERC)'                        'European Union' 'ERC-2020-STG 948783' 1 
'Netherlands Organisation for Scientific Research (NWO)' Netherlands      016.Veni.192.072      2 
'Consejo Nacional de Ciencia y Tecnologia (CONACYT)'     Mexico           682509                3 
'European Molecular Biology Organization (EMBO)'         'European Union' 'ALTF 179-2015'       4 
'European Molecular Biology Organization (EMBO)'         'European Union' 'aALTF 509-2017'      5 
# 
_pdbx_initial_refinement_model.id               1 
_pdbx_initial_refinement_model.entity_id_list   ? 
_pdbx_initial_refinement_model.type             'experimental model' 
_pdbx_initial_refinement_model.source_name      Other 
_pdbx_initial_refinement_model.accession_code   ? 
_pdbx_initial_refinement_model.details          'Use of CtACE1 structure determined in same study' 
# 
_space_group.name_H-M_alt     'P 21 21 21' 
_space_group.name_Hall        'P 2ac 2ab' 
_space_group.IT_number        19 
_space_group.crystal_system   orthorhombic 
_space_group.id               1 
# 
_atom_sites.entry_id                    9IAC 
_atom_sites.Cartn_transf_matrix[1][1]   ? 
_atom_sites.Cartn_transf_matrix[1][2]   ? 
_atom_sites.Cartn_transf_matrix[1][3]   ? 
_atom_sites.Cartn_transf_matrix[2][1]   ? 
_atom_sites.Cartn_transf_matrix[2][2]   ? 
_atom_sites.Cartn_transf_matrix[2][3]   ? 
_atom_sites.Cartn_transf_matrix[3][1]   ? 
_atom_sites.Cartn_transf_matrix[3][2]   ? 
_atom_sites.Cartn_transf_matrix[3][3]   ? 
_atom_sites.Cartn_transf_vector[1]      ? 
_atom_sites.Cartn_transf_vector[2]      ? 
_atom_sites.Cartn_transf_vector[3]      ? 
_atom_sites.Cartn_transform_axes        ? 
_atom_sites.fract_transf_matrix[1][1]   0.012844 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.012842 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.009054 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
_atom_sites.solution_primary            ? 
_atom_sites.solution_secondary          ? 
_atom_sites.solution_hydrogens          ? 
_atom_sites.special_details             ? 
# 
loop_
_atom_type.symbol 
_atom_type.scat_dispersion_real 
_atom_type.scat_dispersion_imag 
_atom_type.scat_Cromer_Mann_a1 
_atom_type.scat_Cromer_Mann_a2 
_atom_type.scat_Cromer_Mann_a3 
_atom_type.scat_Cromer_Mann_a4 
_atom_type.scat_Cromer_Mann_b1 
_atom_type.scat_Cromer_Mann_b2 
_atom_type.scat_Cromer_Mann_b3 
_atom_type.scat_Cromer_Mann_b4 
_atom_type.scat_Cromer_Mann_c 
_atom_type.scat_source 
_atom_type.scat_dispersion_source 
C  ? ? 3.54356  2.42580 ? ? 25.62398 1.50364  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
FE ? ? 20.90327 4.99816 ? ? 2.55100  38.46870 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
MG ? ? 9.41153  2.53737 ? ? 2.59044  63.03566 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
N  ? ? 4.01032  2.96436 ? ? 19.97189 1.75589  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
O  ? ? 4.49882  3.47563 ? ? 15.80542 1.70748  ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
S  ? ? 9.55732  6.39887 ? ? 1.23737  29.19336 ? ? 0.0 
;2-Gaussian fit: Grosse-Kunstleve RW, Sauter NK, Adams PD: Newsletter of the IUCr Commission on Crystallographic Computing 2004, 3, 22-31.
;
? 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . LYS A 1 9   ? 2.10605   16.07049  -7.92518  1.000 87.32901  ? 8   LYS A N   1 
ATOM   2    C  CA  . LYS A 1 9   ? 2.29861   14.84401  -7.15925  1.000 98.22914  ? 8   LYS A CA  1 
ATOM   3    C  C   . LYS A 1 9   ? 2.96633   13.74419  -7.99398  1.000 101.39855 ? 8   LYS A C   1 
ATOM   4    O  O   . LYS A 1 9   ? 2.32649   12.74509  -8.32932  1.000 94.76148  ? 8   LYS A O   1 
ATOM   5    C  CB  . LYS A 1 9   ? 0.95176   14.35224  -6.61622  1.000 92.07225  ? 8   LYS A CB  1 
ATOM   6    N  N   . PRO A 1 10  ? 4.24378   13.92893  -8.34017  1.000 104.79580 ? 9   PRO A N   1 
ATOM   7    C  CA  . PRO A 1 10  ? 4.96964   12.88642  -9.08766  1.000 91.35943  ? 9   PRO A CA  1 
ATOM   8    C  C   . PRO A 1 10  ? 5.35604   11.72797  -8.17614  1.000 82.79935  ? 9   PRO A C   1 
ATOM   9    O  O   . PRO A 1 10  ? 6.04551   11.91559  -7.17356  1.000 79.24862  ? 9   PRO A O   1 
ATOM   10   C  CB  . PRO A 1 10  ? 6.20256   13.62485  -9.62177  1.000 78.93765  ? 9   PRO A CB  1 
ATOM   11   C  CG  . PRO A 1 10  ? 6.43246   14.71849  -8.63207  1.000 88.56920  ? 9   PRO A CG  1 
ATOM   12   C  CD  . PRO A 1 10  ? 5.06639   15.13909  -8.14742  1.000 93.06939  ? 9   PRO A CD  1 
ATOM   13   N  N   . TRP A 1 11  ? 4.90745   10.52773  -8.53294  1.000 79.44052  ? 10  TRP A N   1 
ATOM   14   C  CA  . TRP A 1 11  ? 5.12993   9.35075   -7.70293  1.000 76.11902  ? 10  TRP A CA  1 
ATOM   15   C  C   . TRP A 1 11  ? 6.48504   8.73007   -8.01384  1.000 70.25895  ? 10  TRP A C   1 
ATOM   16   O  O   . TRP A 1 11  ? 6.83293   8.52976   -9.18140  1.000 65.00655  ? 10  TRP A O   1 
ATOM   17   C  CB  . TRP A 1 11  ? 4.01556   8.32699   -7.92330  1.000 72.80964  ? 10  TRP A CB  1 
ATOM   18   C  CG  . TRP A 1 11  ? 4.07927   7.15848   -6.99170  1.000 72.90730  ? 10  TRP A CG  1 
ATOM   19   C  CD1 . TRP A 1 11  ? 3.42681   7.02440   -5.80098  1.000 70.01860  ? 10  TRP A CD1 1 
ATOM   20   C  CD2 . TRP A 1 11  ? 4.83860   5.95686   -7.17165  1.000 76.12779  ? 10  TRP A CD2 1 
ATOM   21   N  NE1 . TRP A 1 11  ? 3.73142   5.81451   -5.22781  1.000 63.11686  ? 10  TRP A NE1 1 
ATOM   22   C  CE2 . TRP A 1 11  ? 4.59715   5.13951   -6.04872  1.000 67.91009  ? 10  TRP A CE2 1 
ATOM   23   C  CE3 . TRP A 1 11  ? 5.69953   5.49191   -8.17341  1.000 75.75866  ? 10  TRP A CE3 1 
ATOM   24   C  CZ2 . TRP A 1 11  ? 5.18544   3.88281   -5.89967  1.000 58.54693  ? 10  TRP A CZ2 1 
ATOM   25   C  CZ3 . TRP A 1 11  ? 6.28175   4.24577   -8.02198  1.000 68.00991  ? 10  TRP A CZ3 1 
ATOM   26   C  CH2 . TRP A 1 11  ? 6.02204   3.45675   -6.89541  1.000 62.74922  ? 10  TRP A CH2 1 
ATOM   27   N  N   . TYR A 1 12  ? 7.24762   8.42929   -6.96696  1.000 60.00908  ? 11  TYR A N   1 
ATOM   28   C  CA  . TYR A 1 12  ? 8.53105   7.75662   -7.07730  1.000 68.10809  ? 11  TYR A CA  1 
ATOM   29   C  C   . TYR A 1 12  ? 8.60372   6.63233   -6.05334  1.000 64.03378  ? 11  TYR A C   1 
ATOM   30   O  O   . TYR A 1 12  ? 7.95090   6.70368   -5.00787  1.000 57.17965  ? 11  TYR A O   1 
ATOM   31   C  CB  . TYR A 1 12  ? 9.69584   8.73798   -6.86499  1.000 63.23511  ? 11  TYR A CB  1 
ATOM   32   C  CG  . TYR A 1 12  ? 9.79611   9.81959   -7.92172  1.000 73.96391  ? 11  TYR A CG  1 
ATOM   33   C  CD1 . TYR A 1 12  ? 10.21840  9.52296   -9.20932  1.000 69.42671  ? 11  TYR A CD1 1 
ATOM   34   C  CD2 . TYR A 1 12  ? 9.48272   11.13786  -7.62680  1.000 67.75495  ? 11  TYR A CD2 1 
ATOM   35   C  CE1 . TYR A 1 12  ? 10.31492  10.50697  -10.17459 1.000 68.98668  ? 11  TYR A CE1 1 
ATOM   36   C  CE2 . TYR A 1 12  ? 9.57834   12.12686  -8.58627  1.000 68.29337  ? 11  TYR A CE2 1 
ATOM   37   C  CZ  . TYR A 1 12  ? 9.99457   11.80657  -9.85719  1.000 75.76766  ? 11  TYR A CZ  1 
ATOM   38   O  OH  . TYR A 1 12  ? 10.09016  12.79013  -10.81258 1.000 73.85261  ? 11  TYR A OH  1 
ATOM   39   N  N   . PRO A 1 13  ? 9.36455   5.57524   -6.33798  1.000 66.82270  ? 12  PRO A N   1 
ATOM   40   C  CA  . PRO A 1 13  ? 9.43944   4.42775   -5.41436  1.000 58.78034  ? 12  PRO A CA  1 
ATOM   41   C  C   . PRO A 1 13  ? 9.95211   4.84471   -4.04888  1.000 51.52248  ? 12  PRO A C   1 
ATOM   42   O  O   . PRO A 1 13  ? 10.89945  5.63671   -3.94922  1.000 57.35543  ? 12  PRO A O   1 
ATOM   43   C  CB  . PRO A 1 13  ? 10.42640  3.48333   -6.11852  1.000 51.19533  ? 12  PRO A CB  1 
ATOM   44   C  CG  . PRO A 1 13  ? 10.32270  3.85698   -7.56017  1.000 58.40517  ? 12  PRO A CG  1 
ATOM   45   C  CD  . PRO A 1 13  ? 10.16280  5.34316   -7.55427  1.000 57.26779  ? 12  PRO A CD  1 
ATOM   46   N  N   . PRO A 1 14  ? 9.37568   4.31311   -2.97454  1.000 54.60356  ? 13  PRO A N   1 
ATOM   47   C  CA  . PRO A 1 14  ? 9.74825   4.75373   -1.62634  1.000 55.01818  ? 13  PRO A CA  1 
ATOM   48   C  C   . PRO A 1 14  ? 10.99515  4.05210   -1.10955  1.000 48.93002  ? 13  PRO A C   1 
ATOM   49   O  O   . PRO A 1 14  ? 11.34314  2.94951   -1.52846  1.000 49.20170  ? 13  PRO A O   1 
ATOM   50   C  CB  . PRO A 1 14  ? 8.52739   4.37134   -0.77586  1.000 51.52963  ? 13  PRO A CB  1 
ATOM   51   C  CG  . PRO A 1 14  ? 7.49528   3.83844   -1.74870  1.000 63.38969  ? 13  PRO A CG  1 
ATOM   52   C  CD  . PRO A 1 14  ? 8.24585   3.37652   -2.94555  1.000 58.69761  ? 13  PRO A CD  1 
ATOM   53   N  N   . MET A 1 15  ? 11.66361  4.71999   -0.17053  1.000 49.44112  ? 14  MET A N   1 
ATOM   54   C  CA  . MET A 1 15  ? 12.75832  4.10445   0.56743   1.000 47.08684  ? 14  MET A CA  1 
ATOM   55   C  C   . MET A 1 15  ? 12.88294  4.77928   1.92540   1.000 54.10901  ? 14  MET A C   1 
ATOM   56   O  O   . MET A 1 15  ? 12.60731  5.97298   2.07066   1.000 49.09946  ? 14  MET A O   1 
ATOM   57   C  CB  . MET A 1 15  ? 14.08892  4.18523   -0.19633  1.000 44.33152  ? 14  MET A CB  1 
ATOM   58   C  CG  . MET A 1 15  ? 15.24923  3.44280   0.47084   1.000 50.33637  ? 14  MET A CG  1 
ATOM   59   S  SD  . MET A 1 15  ? 14.83429  1.75513   0.97779   1.000 58.32097  ? 14  MET A SD  1 
ATOM   60   C  CE  . MET A 1 15  ? 14.34226  1.02581   -0.58225  1.000 45.18713  ? 14  MET A CE  1 
ATOM   61   N  N   . SER A 1 16  ? 13.29670  3.99430   2.91712   1.000 53.26234  ? 15  SER A N   1 
ATOM   62   C  CA  . SER A 1 16  ? 13.46579  4.46106   4.28601   1.000 51.25604  ? 15  SER A CA  1 
ATOM   63   C  C   . SER A 1 16  ? 14.41344  3.50434   4.98879   1.000 49.27398  ? 15  SER A C   1 
ATOM   64   O  O   . SER A 1 16  ? 14.68349  2.40736   4.49231   1.000 47.16560  ? 15  SER A O   1 
ATOM   65   C  CB  . SER A 1 16  ? 12.12552  4.53781   5.02512   1.000 49.81862  ? 15  SER A CB  1 
ATOM   66   O  OG  . SER A 1 16  ? 11.47573  3.27702   5.04461   1.000 47.22816  ? 15  SER A OG  1 
ATOM   67   N  N   . TYR A 1 17  ? 14.93348  3.93345   6.14441   1.000 46.20868  ? 16  TYR A N   1 
ATOM   68   C  CA  . TYR A 1 17  ? 15.70092  2.99987   6.96282   1.000 53.58958  ? 16  TYR A CA  1 
ATOM   69   C  C   . TYR A 1 17  ? 14.83245  1.82424   7.38660   1.000 45.39499  ? 16  TYR A C   1 
ATOM   70   O  O   . TYR A 1 17  ? 15.30733  0.68714   7.47500   1.000 50.00483  ? 16  TYR A O   1 
ATOM   71   C  CB  . TYR A 1 17  ? 16.28585  3.68150   8.19938   1.000 53.10740  ? 16  TYR A CB  1 
ATOM   72   C  CG  . TYR A 1 17  ? 16.77014  2.64828   9.18596   1.000 54.61185  ? 16  TYR A CG  1 
ATOM   73   C  CD1 . TYR A 1 17  ? 17.84963  1.83235   8.87681   1.000 50.94755  ? 16  TYR A CD1 1 
ATOM   74   C  CD2 . TYR A 1 17  ? 16.12309  2.44996   10.39779  1.000 58.74128  ? 16  TYR A CD2 1 
ATOM   75   C  CE1 . TYR A 1 17  ? 18.28873  0.86570   9.75305   1.000 59.43327  ? 16  TYR A CE1 1 
ATOM   76   C  CE2 . TYR A 1 17  ? 16.55810  1.48291   11.28552  1.000 53.00283  ? 16  TYR A CE2 1 
ATOM   77   C  CZ  . TYR A 1 17  ? 17.64142  0.69417   10.95723  1.000 58.76500  ? 16  TYR A CZ  1 
ATOM   78   O  OH  . TYR A 1 17  ? 18.07292  -0.26900  11.83605  1.000 54.01744  ? 16  TYR A OH  1 
ATOM   79   N  N   . SER A 1 18  ? 13.55341  2.08756   7.66264   1.000 46.39460  ? 17  SER A N   1 
ATOM   80   C  CA  . SER A 1 18  ? 12.62407  1.01571   7.99380   1.000 53.44187  ? 17  SER A CA  1 
ATOM   81   C  C   . SER A 1 18  ? 12.49037  0.03317   6.83959   1.000 52.33801  ? 17  SER A C   1 
ATOM   82   O  O   . SER A 1 18  ? 12.50144  -1.18397  7.04868   1.000 46.80992  ? 17  SER A O   1 
ATOM   83   C  CB  . SER A 1 18  ? 11.26658  1.61150   8.36204   1.000 50.26827  ? 17  SER A CB  1 
ATOM   84   O  OG  . SER A 1 18  ? 10.34378  0.61219   8.75557   1.000 59.55889  ? 17  SER A OG  1 
ATOM   85   N  N   . LEU A 1 19  ? 12.39412  0.54135   5.60836   1.000 49.34725  ? 18  LEU A N   1 
ATOM   86   C  CA  . LEU A 1 19  ? 12.27718  -0.34465  4.45300   1.000 51.11419  ? 18  LEU A CA  1 
ATOM   87   C  C   . LEU A 1 19  ? 13.57388  -1.11146  4.21815   1.000 49.50818  ? 18  LEU A C   1 
ATOM   88   O  O   . LEU A 1 19  ? 13.55822  -2.32434  3.97335   1.000 50.13974  ? 18  LEU A O   1 
ATOM   89   C  CB  . LEU A 1 19  ? 11.89499  0.45487   3.20656   1.000 53.37737  ? 18  LEU A CB  1 
ATOM   90   C  CG  . LEU A 1 19  ? 11.32844  -0.41822  2.08492   1.000 52.08330  ? 18  LEU A CG  1 
ATOM   91   C  CD1 . LEU A 1 19  ? 10.08465  -1.13645  2.56692   1.000 57.73978  ? 18  LEU A CD1 1 
ATOM   92   C  CD2 . LEU A 1 19  ? 11.02148  0.39813   0.84457   1.000 58.56464  ? 18  LEU A CD2 1 
ATOM   93   N  N   . TRP A 1 20  ? 14.70768  -0.40929  4.28110   1.000 45.17340  ? 19  TRP A N   1 
ATOM   94   C  CA  . TRP A 1 20  ? 16.01539  -1.04676  4.15132   1.000 47.00180  ? 19  TRP A CA  1 
ATOM   95   C  C   . TRP A 1 20  ? 16.16720  -2.18538  5.15533   1.000 50.43054  ? 19  TRP A C   1 
ATOM   96   O  O   . TRP A 1 20  ? 16.58041  -3.29593  4.80143   1.000 45.92503  ? 19  TRP A O   1 
ATOM   97   C  CB  . TRP A 1 20  ? 17.11072  0.01022   4.34398   1.000 48.04061  ? 19  TRP A CB  1 
ATOM   98   C  CG  . TRP A 1 20  ? 18.51891  -0.43292  4.02951   1.000 46.04673  ? 19  TRP A CG  1 
ATOM   99   C  CD1 . TRP A 1 20  ? 18.92332  -1.67725  3.65247   1.000 55.32042  ? 19  TRP A CD1 1 
ATOM   100  C  CD2 . TRP A 1 20  ? 19.70664  0.37910   4.06912   1.000 52.87474  ? 19  TRP A CD2 1 
ATOM   101  N  NE1 . TRP A 1 20  ? 20.28341  -1.69348  3.45282   1.000 60.36202  ? 19  TRP A NE1 1 
ATOM   102  C  CE2 . TRP A 1 20  ? 20.78789  -0.44510  3.70242   1.000 50.00910  ? 19  TRP A CE2 1 
ATOM   103  C  CE3 . TRP A 1 20  ? 19.95670  1.72083   4.37979   1.000 44.10978  ? 19  TRP A CE3 1 
ATOM   104  C  CZ2 . TRP A 1 20  ? 22.09788  0.02467   3.63559   1.000 54.94237  ? 19  TRP A CZ2 1 
ATOM   105  C  CZ3 . TRP A 1 20  ? 21.25777  2.18730   4.31315   1.000 45.62235  ? 19  TRP A CZ3 1 
ATOM   106  C  CH2 . TRP A 1 20  ? 22.31259  1.34016   3.94459   1.000 56.23105  ? 19  TRP A CH2 1 
ATOM   107  N  N   . ARG A 1 21  ? 15.81738  -1.92216  6.41792   1.000 50.45014  ? 20  ARG A N   1 
ATOM   108  C  CA  . ARG A 1 21  ? 15.85220  -2.95669  7.44789   1.000 54.75633  ? 20  ARG A CA  1 
ATOM   109  C  C   . ARG A 1 21  ? 14.88673  -4.09458  7.12374   1.000 45.90728  ? 20  ARG A C   1 
ATOM   110  O  O   . ARG A 1 21  ? 15.20995  -5.26983  7.32231   1.000 48.12353  ? 20  ARG A O   1 
ATOM   111  C  CB  . ARG A 1 21  ? 15.53180  -2.33210  8.81057   1.000 57.16772  ? 20  ARG A CB  1 
ATOM   112  C  CG  . ARG A 1 21  ? 15.43243  -3.30450  9.97678   1.000 60.36494  ? 20  ARG A CG  1 
ATOM   113  C  CD  . ARG A 1 21  ? 15.37686  -2.55656  11.30186  1.000 64.72504  ? 20  ARG A CD  1 
ATOM   114  N  NE  . ARG A 1 21  ? 14.36607  -1.50779  11.28158  1.000 69.69588  ? 20  ARG A NE  1 
ATOM   115  C  CZ  . ARG A 1 21  ? 13.97384  -0.83367  12.35446  1.000 77.59778  ? 20  ARG A CZ  1 
ATOM   116  N  NH1 . ARG A 1 21  ? 14.48121  -1.07920  13.55297  1.000 72.05916  ? 20  ARG A NH1 1 
ATOM   117  N  NH2 . ARG A 1 21  ? 13.04575  0.10763   12.22575  1.000 68.75745  ? 20  ARG A NH2 1 
ATOM   118  N  N   . SER A 1 22  ? 13.69150  -3.76543  6.63103   1.000 45.71703  ? 21  SER A N   1 
ATOM   119  C  CA  . SER A 1 22  ? 12.72297  -4.78771  6.25305   1.000 50.92458  ? 21  SER A CA  1 
ATOM   120  C  C   . SER A 1 22  ? 13.21516  -5.65428  5.09707   1.000 50.10097  ? 21  SER A C   1 
ATOM   121  O  O   . SER A 1 22  ? 12.79780  -6.81112  4.98469   1.000 54.40357  ? 21  SER A O   1 
ATOM   122  C  CB  . SER A 1 22  ? 11.38855  -4.12456  5.88853   1.000 52.44988  ? 21  SER A CB  1 
ATOM   123  O  OG  . SER A 1 22  ? 10.80357  -3.49477  7.01629   1.000 58.06236  ? 21  SER A OG  1 
ATOM   124  N  N   . LEU A 1 23  ? 14.12753  -5.14614  4.26936   1.000 52.92106  ? 22  LEU A N   1 
ATOM   125  C  CA  . LEU A 1 23  ? 14.57868  -5.84695  3.07063   1.000 56.61245  ? 22  LEU A CA  1 
ATOM   126  C  C   . LEU A 1 23  ? 15.88778  -6.59543  3.25173   1.000 49.96011  ? 22  LEU A C   1 
ATOM   127  O  O   . LEU A 1 23  ? 16.03793  -7.69736  2.71753   1.000 51.98203  ? 22  LEU A O   1 
ATOM   128  C  CB  . LEU A 1 23  ? 14.72016  -4.85667  1.91109   1.000 48.49209  ? 22  LEU A CB  1 
ATOM   129  C  CG  . LEU A 1 23  ? 13.38736  -4.44022  1.29295   1.000 43.63290  ? 22  LEU A CG  1 
ATOM   130  C  CD1 . LEU A 1 23  ? 13.49844  -3.07309  0.66649   1.000 59.67290  ? 22  LEU A CD1 1 
ATOM   131  C  CD2 . LEU A 1 23  ? 12.96331  -5.45514  0.25583   1.000 52.33921  ? 22  LEU A CD2 1 
ATOM   132  N  N   . LYS A 1 24  ? 16.84929  -6.02191  3.96868   1.000 41.29489  ? 23  LYS A N   1 
ATOM   133  C  CA  . LYS A 1 24  ? 18.09916  -6.69702  4.24955   1.000 46.84622  ? 23  LYS A CA  1 
ATOM   134  C  C   . LYS A 1 24  ? 18.28435  -6.81068  5.75492   1.000 53.16831  ? 23  LYS A C   1 
ATOM   135  O  O   . LYS A 1 24  ? 18.19553  -5.79747  6.46417   1.000 51.76734  ? 23  LYS A O   1 
ATOM   136  C  CB  . LYS A 1 24  ? 19.29971  -5.95845  3.63334   1.000 40.21693  ? 23  LYS A CB  1 
ATOM   137  C  CG  . LYS A 1 24  ? 19.78656  -6.53489  2.31392   1.000 53.88971  ? 23  LYS A CG  1 
ATOM   138  C  CD  . LYS A 1 24  ? 21.23043  -6.13537  2.04206   1.000 57.36967  ? 23  LYS A CD  1 
ATOM   139  C  CE  . LYS A 1 24  ? 21.70732  -6.64709  0.69296   1.000 68.37488  ? 23  LYS A CE  1 
ATOM   140  N  NZ  . LYS A 1 24  ? 23.14640  -6.34164  0.45828   1.000 76.84696  ? 23  LYS A NZ  1 
ATOM   141  N  N   . PRO A 1 25  ? 18.51618  -8.00795  6.28537   1.000 59.03291  ? 24  PRO A N   1 
ATOM   142  C  CA  . PRO A 1 25  ? 18.89215  -8.11201  7.69529   1.000 51.14770  ? 24  PRO A CA  1 
ATOM   143  C  C   . PRO A 1 25  ? 20.25714  -7.48663  7.91060   1.000 56.92774  ? 24  PRO A C   1 
ATOM   144  O  O   . PRO A 1 25  ? 21.13893  -7.56296  7.04942   1.000 58.98925  ? 24  PRO A O   1 
ATOM   145  C  CB  . PRO A 1 25  ? 18.91919  -9.62294  7.94550   1.000 57.66531  ? 24  PRO A CB  1 
ATOM   146  C  CG  . PRO A 1 25  ? 19.25288  -10.20022 6.61069   1.000 53.52156  ? 24  PRO A CG  1 
ATOM   147  C  CD  . PRO A 1 25  ? 18.57522  -9.31208  5.60196   1.000 54.54064  ? 24  PRO A CD  1 
ATOM   148  N  N   . ALA A 1 26  ? 20.42230  -6.85077  9.06332   1.000 58.94895  ? 25  ALA A N   1 
ATOM   149  C  CA  . ALA A 1 26  ? 21.73977  -6.37093  9.44200   1.000 59.10157  ? 25  ALA A CA  1 
ATOM   150  C  C   . ALA A 1 26  ? 22.65830  -7.56448  9.66495   1.000 65.89697  ? 25  ALA A C   1 
ATOM   151  O  O   . ALA A 1 26  ? 22.22361  -8.61109  10.15277  1.000 71.42058  ? 25  ALA A O   1 
ATOM   152  C  CB  . ALA A 1 26  ? 21.65450  -5.51163  10.70229  1.000 62.30486  ? 25  ALA A CB  1 
ATOM   153  N  N   . ILE A 1 27  ? 23.92431  -7.42377  9.26980   1.000 65.32964  ? 26  ILE A N   1 
ATOM   154  C  CA  . ILE A 1 27  ? 24.89811  -8.49521  9.46091   1.000 72.48132  ? 26  ILE A CA  1 
ATOM   155  C  C   . ILE A 1 27  ? 24.93272  -8.86529  10.93877  1.000 74.96010  ? 26  ILE A C   1 
ATOM   156  O  O   . ILE A 1 27  ? 25.13167  -8.00222  11.80076  1.000 71.24826  ? 26  ILE A O   1 
ATOM   157  C  CB  . ILE A 1 27  ? 26.29682  -8.08604  8.96486   1.000 72.82877  ? 26  ILE A CB  1 
ATOM   158  C  CG1 . ILE A 1 27  ? 26.21188  -7.41468  7.59347   1.000 66.22404  ? 26  ILE A CG1 1 
ATOM   159  C  CG2 . ILE A 1 27  ? 27.20998  -9.29697  8.90313   1.000 73.45259  ? 26  ILE A CG2 1 
ATOM   160  C  CD1 . ILE A 1 27  ? 27.52575  -6.81191  7.12373   1.000 66.01483  ? 26  ILE A CD1 1 
ATOM   161  N  N   . GLY A 1 28  ? 24.72311  -10.14476 11.24366  1.000 76.24034  ? 27  GLY A N   1 
ATOM   162  C  CA  . GLY A 1 28  ? 24.67375  -10.61635 12.61067  1.000 68.95167  ? 27  GLY A CA  1 
ATOM   163  C  C   . GLY A 1 28  ? 23.27889  -10.84541 13.15426  1.000 67.55617  ? 27  GLY A C   1 
ATOM   164  O  O   . GLY A 1 28  ? 23.14336  -11.36965 14.26658  1.000 70.79382  ? 27  GLY A O   1 
ATOM   165  N  N   . TYR A 1 29  ? 22.24185  -10.44777 12.41711  1.000 65.12169  ? 28  TYR A N   1 
ATOM   166  C  CA  . TYR A 1 29  ? 20.85669  -10.64817 12.82793  1.000 60.93509  ? 28  TYR A CA  1 
ATOM   167  C  C   . TYR A 1 29  ? 20.06359  -11.39418 11.75878  1.000 60.81701  ? 28  TYR A C   1 
ATOM   168  O  O   . TYR A 1 29  ? 18.83335  -11.28496 11.71104  1.000 65.04918  ? 28  TYR A O   1 
ATOM   169  C  CB  . TYR A 1 29  ? 20.19305  -9.30461  13.15227  1.000 60.31493  ? 28  TYR A CB  1 
ATOM   170  C  CG  . TYR A 1 29  ? 20.82015  -8.54027  14.31238  1.000 67.26609  ? 28  TYR A CG  1 
ATOM   171  C  CD1 . TYR A 1 29  ? 22.09480  -7.99109  14.21056  1.000 73.66012  ? 28  TYR A CD1 1 
ATOM   172  C  CD2 . TYR A 1 29  ? 20.12731  -8.35141  15.50156  1.000 70.10517  ? 28  TYR A CD2 1 
ATOM   173  C  CE1 . TYR A 1 29  ? 22.66495  -7.29346  15.26364  1.000 77.21047  ? 28  TYR A CE1 1 
ATOM   174  C  CE2 . TYR A 1 29  ? 20.69112  -7.65115  16.55920  1.000 77.41422  ? 28  TYR A CE2 1 
ATOM   175  C  CZ  . TYR A 1 29  ? 21.95921  -7.12501  16.43268  1.000 78.79523  ? 28  TYR A CZ  1 
ATOM   176  O  OH  . TYR A 1 29  ? 22.53072  -6.43049  17.47518  1.000 88.60419  ? 28  TYR A OH  1 
ATOM   177  N  N   . GLU A 1 30  ? 20.75195  -12.15894 10.90391  1.000 59.56549  ? 29  GLU A N   1 
ATOM   178  C  CA  . GLU A 1 30  ? 20.10855  -12.76710 9.74284   1.000 64.92223  ? 29  GLU A CA  1 
ATOM   179  C  C   . GLU A 1 30  ? 19.00494  -13.74040 10.13706  1.000 66.92476  ? 29  GLU A C   1 
ATOM   180  O  O   . GLU A 1 30  ? 18.00865  -13.87094 9.41522   1.000 63.42504  ? 29  GLU A O   1 
ATOM   181  C  CB  . GLU A 1 30  ? 21.15360  -13.47955 8.87869   1.000 57.31610  ? 29  GLU A CB  1 
ATOM   182  C  CG  . GLU A 1 30  ? 22.21553  -12.57025 8.26374   1.000 62.23272  ? 29  GLU A CG  1 
ATOM   183  C  CD  . GLU A 1 30  ? 23.50795  -12.54188 9.05896   1.000 73.64544  ? 29  GLU A CD  1 
ATOM   184  O  OE1 . GLU A 1 30  ? 23.44493  -12.44698 10.30155  1.000 70.85857  ? 29  GLU A OE1 1 
ATOM   185  O  OE2 . GLU A 1 30  ? 24.58941  -12.63667 8.43822   1.000 77.34376  ? 29  GLU A OE2 1 
ATOM   186  N  N   . ASN A 1 31  ? 19.15558  -14.42651 11.26906  1.000 62.75068  ? 30  ASN A N   1 
ATOM   187  C  CA  . ASN A 1 31  ? 18.17925  -15.43210 11.66149  1.000 63.02337  ? 30  ASN A CA  1 
ATOM   188  C  C   . ASN A 1 31  ? 16.93999  -14.82258 12.30373  1.000 62.05759  ? 30  ASN A C   1 
ATOM   189  O  O   . ASN A 1 31  ? 15.96559  -15.54382 12.54641  1.000 65.52789  ? 30  ASN A O   1 
ATOM   190  C  CB  . ASN A 1 31  ? 18.83349  -16.44601 12.60682  1.000 69.57820  ? 30  ASN A CB  1 
ATOM   191  C  CG  . ASN A 1 31  ? 18.08904  -17.76569 12.65274  1.000 64.25916  ? 30  ASN A CG  1 
ATOM   192  O  OD1 . ASN A 1 31  ? 17.93044  -18.43470 11.63041  1.000 65.45672  ? 30  ASN A OD1 1 
ATOM   193  N  ND2 . ASN A 1 31  ? 17.64004  -18.15496 13.84266  1.000 67.76351  ? 30  ASN A ND2 1 
ATOM   194  N  N   . TRP A 1 32  ? 16.94409  -13.51245 12.54724  1.000 67.30144  ? 31  TRP A N   1 
ATOM   195  C  CA  . TRP A 1 32  ? 15.79767  -12.81324 13.11226  1.000 66.42530  ? 31  TRP A CA  1 
ATOM   196  C  C   . TRP A 1 32  ? 15.19706  -11.86876 12.08190  1.000 67.55539  ? 31  TRP A C   1 
ATOM   197  O  O   . TRP A 1 32  ? 14.85327  -10.72823 12.40833  1.000 66.59741  ? 31  TRP A O   1 
ATOM   198  C  CB  . TRP A 1 32  ? 16.19893  -12.01331 14.35061  1.000 62.95395  ? 31  TRP A CB  1 
ATOM   199  C  CG  . TRP A 1 32  ? 16.61242  -12.83002 15.52171  1.000 72.39895  ? 31  TRP A CG  1 
ATOM   200  C  CD1 . TRP A 1 32  ? 16.60103  -14.18789 15.62135  1.000 69.03480  ? 31  TRP A CD1 1 
ATOM   201  C  CD2 . TRP A 1 32  ? 17.09644  -12.33645 16.77826  1.000 66.39623  ? 31  TRP A CD2 1 
ATOM   202  N  NE1 . TRP A 1 32  ? 17.04687  -14.57261 16.86325  1.000 67.34892  ? 31  TRP A NE1 1 
ATOM   203  C  CE2 . TRP A 1 32  ? 17.35852  -13.45505 17.59157  1.000 70.26835  ? 31  TRP A CE2 1 
ATOM   204  C  CE3 . TRP A 1 32  ? 17.33761  -11.05785 17.29104  1.000 65.55451  ? 31  TRP A CE3 1 
ATOM   205  C  CZ2 . TRP A 1 32  ? 17.84851  -13.33711 18.88927  1.000 66.46446  ? 31  TRP A CZ2 1 
ATOM   206  C  CZ3 . TRP A 1 32  ? 17.82430  -10.94241 18.58381  1.000 62.06366  ? 31  TRP A CZ3 1 
ATOM   207  C  CH2 . TRP A 1 32  ? 18.07356  -12.07629 19.36664  1.000 65.19218  ? 31  TRP A CH2 1 
ATOM   208  N  N   . HIS A 1 33  ? 15.07603  -12.32853 10.83736  1.000 62.59021  ? 32  HIS A N   1 
ATOM   209  C  CA  . HIS A 1 33  ? 14.59280  -11.49950 9.73527   1.000 58.48257  ? 32  HIS A CA  1 
ATOM   210  C  C   . HIS A 1 33  ? 13.61599  -12.33175 8.91818   1.000 55.77870  ? 32  HIS A C   1 
ATOM   211  O  O   . HIS A 1 33  ? 14.01143  -13.32909 8.30784   1.000 56.78510  ? 32  HIS A O   1 
ATOM   212  C  CB  . HIS A 1 33  ? 15.74933  -11.00173 8.86575   1.000 55.40956  ? 32  HIS A CB  1 
ATOM   213  C  CG  . HIS A 1 33  ? 15.36035  -9.91565  7.91170   1.000 59.05604  ? 32  HIS A CG  1 
ATOM   214  N  ND1 . HIS A 1 33  ? 15.51702  -10.02778 6.54650   1.000 57.37178  ? 32  HIS A ND1 1 
ATOM   215  C  CD2 . HIS A 1 33  ? 14.80946  -8.69788  8.12727   1.000 55.77719  ? 32  HIS A CD2 1 
ATOM   216  C  CE1 . HIS A 1 33  ? 15.08543  -8.92410  5.96274   1.000 54.28510  ? 32  HIS A CE1 1 
ATOM   217  N  NE2 . HIS A 1 33  ? 14.64957  -8.10154  6.89990   1.000 54.00005  ? 32  HIS A NE2 1 
ATOM   218  N  N   . CYS A 1 34  ? 12.34509  -11.93415 8.90921   1.000 49.14652  ? 33  CYS A N   1 
ATOM   219  C  CA  . CYS A 1 34  ? 11.30036  -12.66995 8.20082   1.000 55.47466  ? 33  CYS A CA  1 
ATOM   220  C  C   . CYS A 1 34  ? 10.70245  -11.78035 7.11603   1.000 55.78993  ? 33  CYS A C   1 
ATOM   221  O  O   . CYS A 1 34  ? 10.06212  -10.76712 7.41920   1.000 49.53294  ? 33  CYS A O   1 
ATOM   222  C  CB  . CYS A 1 34  ? 10.21818  -13.16028 9.16200   1.000 50.04511  ? 33  CYS A CB  1 
ATOM   223  S  SG  . CYS A 1 34  ? 8.87198   -14.03938 8.33248   1.000 54.58742  ? 33  CYS A SG  1 
ATOM   224  N  N   . GLN A 1 35  ? 10.90239  -12.17350 5.85297   1.000 52.22068  ? 34  GLN A N   1 
ATOM   225  C  CA  . GLN A 1 35  ? 10.38557  -11.39853 4.72817   1.000 48.87022  ? 34  GLN A CA  1 
ATOM   226  C  C   . GLN A 1 35  ? 8.86492   -11.28777 4.75769   1.000 45.52080  ? 34  GLN A C   1 
ATOM   227  O  O   . GLN A 1 35  ? 8.30428   -10.29503 4.27421   1.000 45.79226  ? 34  GLN A O   1 
ATOM   228  C  CB  . GLN A 1 35  ? 10.84711  -12.02980 3.41496   1.000 51.15214  ? 34  GLN A CB  1 
ATOM   229  C  CG  . GLN A 1 35  ? 12.35557  -12.04152 3.22262   1.000 54.14905  ? 34  GLN A CG  1 
ATOM   230  C  CD  . GLN A 1 35  ? 12.75760  -12.39872 1.80754   1.000 67.10969  ? 34  GLN A CD  1 
ATOM   231  O  OE1 . GLN A 1 35  ? 12.21119  -11.87252 0.83815   1.000 66.15747  ? 34  GLN A OE1 1 
ATOM   232  N  NE2 . GLN A 1 35  ? 13.71901  -13.30006 1.68173   1.000 64.08386  ? 34  GLN A NE2 1 
ATOM   233  N  N   . THR A 1 36  ? 8.18229   -12.29198 5.31329   1.000 46.84578  ? 35  THR A N   1 
ATOM   234  C  CA  . THR A 1 36  ? 6.72890   -12.23170 5.41833   1.000 49.83326  ? 35  THR A CA  1 
ATOM   235  C  C   . THR A 1 36  ? 6.28752   -11.08870 6.32046   1.000 55.18821  ? 35  THR A C   1 
ATOM   236  O  O   . THR A 1 36  ? 5.19534   -10.53482 6.14394   1.000 52.66671  ? 35  THR A O   1 
ATOM   237  C  CB  . THR A 1 36  ? 6.18980   -13.55886 5.94064   1.000 45.51663  ? 35  THR A CB  1 
ATOM   238  O  OG1 . THR A 1 36  ? 6.88998   -14.62495 5.30078   1.000 55.98619  ? 35  THR A OG1 1 
ATOM   239  C  CG2 . THR A 1 36  ? 4.70598   -13.69328 5.62864   1.000 43.96363  ? 35  THR A CG2 1 
ATOM   240  N  N   . LYS A 1 37  ? 7.11579   -10.72169 7.29695   1.000 52.12266  ? 36  LYS A N   1 
ATOM   241  C  CA  . LYS A 1 37  ? 6.79483   -9.55577  8.10807   1.000 57.72013  ? 36  LYS A CA  1 
ATOM   242  C  C   . LYS A 1 37  ? 6.76550   -8.29424  7.25359   1.000 52.96483  ? 36  LYS A C   1 
ATOM   243  O  O   . LYS A 1 37  ? 5.87666   -7.44779  7.41075   1.000 55.56977  ? 36  LYS A O   1 
ATOM   244  C  CB  . LYS A 1 37  ? 7.79889   -9.42898  9.24824   1.000 57.36775  ? 36  LYS A CB  1 
ATOM   245  C  CG  . LYS A 1 37  ? 7.52287   -8.29410  10.20193  1.000 63.41288  ? 36  LYS A CG  1 
ATOM   246  C  CD  . LYS A 1 37  ? 8.57883   -8.25990  11.28974  1.000 65.13740  ? 36  LYS A CD  1 
ATOM   247  C  CE  . LYS A 1 37  ? 8.46525   -7.01763  12.15083  1.000 71.99359  ? 36  LYS A CE  1 
ATOM   248  N  NZ  . LYS A 1 37  ? 9.56487   -6.95943  13.15072  1.000 72.43362  ? 36  LYS A NZ  1 
ATOM   249  N  N   . ARG A 1 38  ? 7.72878   -8.15503  6.33792   1.000 52.52747  ? 37  ARG A N   1 
ATOM   250  C  CA  . ARG A 1 38  ? 7.68701   -7.05343  5.38165   1.000 53.64742  ? 37  ARG A CA  1 
ATOM   251  C  C   . ARG A 1 38  ? 6.48074   -7.17058  4.45545   1.000 51.51299  ? 37  ARG A C   1 
ATOM   252  O  O   . ARG A 1 38  ? 5.89530   -6.16199  4.05384   1.000 48.11611  ? 37  ARG A O   1 
ATOM   253  C  CB  . ARG A 1 38  ? 8.98988   -7.00686  4.58528   1.000 51.38987  ? 37  ARG A CB  1 
ATOM   254  C  CG  . ARG A 1 38  ? 9.04715   -5.91065  3.53058   1.000 49.32446  ? 37  ARG A CG  1 
ATOM   255  C  CD  . ARG A 1 38  ? 10.42462  -5.84250  2.88486   1.000 57.30386  ? 37  ARG A CD  1 
ATOM   256  N  NE  . ARG A 1 38  ? 10.90567  -7.16043  2.48940   1.000 52.91305  ? 37  ARG A NE  1 
ATOM   257  C  CZ  . ARG A 1 38  ? 10.65862  -7.72308  1.31310   1.000 60.84490  ? 37  ARG A CZ  1 
ATOM   258  N  NH1 . ARG A 1 38  ? 9.96651   -7.09662  0.37393   1.000 57.85169  ? 37  ARG A NH1 1 
ATOM   259  N  NH2 . ARG A 1 38  ? 11.11284  -8.94707  1.07137   1.000 57.49529  ? 37  ARG A NH2 1 
ATOM   260  N  N   . GLY A 1 39  ? 6.09303   -8.39439  4.10357   1.000 45.04779  ? 38  GLY A N   1 
ATOM   261  C  CA  . GLY A 1 39  ? 4.91281   -8.59133  3.27639   1.000 51.37869  ? 38  GLY A CA  1 
ATOM   262  C  C   . GLY A 1 39  ? 3.61141   -8.27942  3.98735   1.000 54.21971  ? 38  GLY A C   1 
ATOM   263  O  O   . GLY A 1 39  ? 2.56522   -8.15965  3.33965   1.000 61.78516  ? 38  GLY A O   1 
ATOM   264  N  N   . PHE A 1 40  ? 3.64250   -8.21868  5.31385   1.000 54.85796  ? 39  PHE A N   1 
ATOM   265  C  CA  . PHE A 1 40  ? 2.49468   -7.71322  6.06219   1.000 56.19099  ? 39  PHE A CA  1 
ATOM   266  C  C   . PHE A 1 40  ? 2.56410   -6.20343  6.25922   1.000 54.03786  ? 39  PHE A C   1 
ATOM   267  O  O   . PHE A 1 40  ? 1.53547   -5.51945  6.18051   1.000 60.10409  ? 39  PHE A O   1 
ATOM   268  C  CB  . PHE A 1 40  ? 2.38990   -8.40110  7.42267   1.000 62.16647  ? 39  PHE A CB  1 
ATOM   269  C  CG  . PHE A 1 40  ? 1.67010   -9.71744  7.38538   1.000 54.67305  ? 39  PHE A CG  1 
ATOM   270  C  CD1 . PHE A 1 40  ? 0.33968   -9.79045  6.99405   1.000 58.78056  ? 39  PHE A CD1 1 
ATOM   271  C  CD2 . PHE A 1 40  ? 2.31660   -10.87868 7.76752   1.000 55.92673  ? 39  PHE A CD2 1 
ATOM   272  C  CE1 . PHE A 1 40  ? -0.32294  -11.00107 6.96899   1.000 42.56739  ? 39  PHE A CE1 1 
ATOM   273  C  CE2 . PHE A 1 40  ? 1.65900   -12.09117 7.74643   1.000 56.79860  ? 39  PHE A CE2 1 
ATOM   274  C  CZ  . PHE A 1 40  ? 0.33609   -12.15242 7.34583   1.000 49.71644  ? 39  PHE A CZ  1 
ATOM   275  N  N   . GLU A 1 41  ? 3.75924   -5.67354  6.54071   1.000 53.23161  ? 40  GLU A N   1 
ATOM   276  C  CA  . GLU A 1 41  ? 3.89317   -4.24235  6.80265   1.000 55.57149  ? 40  GLU A CA  1 
ATOM   277  C  C   . GLU A 1 41  ? 3.65016   -3.42948  5.53769   1.000 61.38888  ? 40  GLU A C   1 
ATOM   278  O  O   . GLU A 1 41  ? 2.94388   -2.41529  5.56032   1.000 58.69754  ? 40  GLU A O   1 
ATOM   279  C  CB  . GLU A 1 41  ? 5.27058   -3.94090  7.38200   1.000 55.76866  ? 40  GLU A CB  1 
ATOM   280  C  CG  . GLU A 1 41  ? 5.38478   -4.28741  8.84392   1.000 60.96025  ? 40  GLU A CG  1 
ATOM   281  C  CD  . GLU A 1 41  ? 6.80351   -4.59651  9.25052   1.000 70.09241  ? 40  GLU A CD  1 
ATOM   282  O  OE1 . GLU A 1 41  ? 7.68132   -4.69816  8.36502   1.000 67.27101  ? 40  GLU A OE1 1 
ATOM   283  O  OE2 . GLU A 1 41  ? 7.04589   -4.74582  10.46260  1.000 73.52792  ? 40  GLU A OE2 1 
ATOM   284  N  N   . LYS A 1 42  ? 4.24681   -3.84580  4.43165   1.000 52.97518  ? 41  LYS A N   1 
ATOM   285  C  CA  . LYS A 1 42  ? 3.83346   -3.42204  3.10548   1.000 56.57621  ? 41  LYS A CA  1 
ATOM   286  C  C   . LYS A 1 42  ? 2.97942   -4.52824  2.49199   1.000 65.02251  ? 41  LYS A C   1 
ATOM   287  O  O   . LYS A 1 42  ? 2.92060   -5.64622  3.00611   1.000 76.69953  ? 41  LYS A O   1 
ATOM   288  C  CB  . LYS A 1 42  ? 5.04697   -3.13049  2.21784   1.000 51.17888  ? 41  LYS A CB  1 
ATOM   289  C  CG  . LYS A 1 42  ? 6.14894   -2.34329  2.91421   1.000 61.27049  ? 41  LYS A CG  1 
ATOM   290  C  CD  . LYS A 1 42  ? 5.65495   -0.95943  3.32302   1.000 64.57390  ? 41  LYS A CD  1 
ATOM   291  C  CE  . LYS A 1 42  ? 6.52467   -0.35864  4.41690   1.000 60.52205  ? 41  LYS A CE  1 
ATOM   292  N  NZ  . LYS A 1 42  ? 6.00755   0.97572   4.85111   1.000 51.50267  ? 41  LYS A NZ  1 
ATOM   293  N  N   . ALA A 1 43  ? 2.26116   -4.17750  1.42310   1.000 54.76339  ? 42  ALA A N   1 
ATOM   294  C  CA  . ALA A 1 43  ? 1.61009   -5.12159  0.50979   1.000 60.21503  ? 42  ALA A CA  1 
ATOM   295  C  C   . ALA A 1 43  ? 0.37937   -5.83446  1.05641   1.000 56.94351  ? 42  ALA A C   1 
ATOM   296  O  O   . ALA A 1 43  ? -0.36863  -6.44547  0.29118   1.000 77.23231  ? 42  ALA A O   1 
ATOM   297  C  CB  . ALA A 1 43  ? 2.60202   -6.20059  0.07092   1.000 49.20157  ? 42  ALA A CB  1 
ATOM   298  N  N   . ARG A 1 44  ? 0.14681   -5.76017  2.35941   1.000 65.61129  ? 43  ARG A N   1 
ATOM   299  C  CA  . ARG A 1 44  ? -1.06519  -6.29417  2.96839   1.000 62.35703  ? 43  ARG A CA  1 
ATOM   300  C  C   . ARG A 1 44  ? -1.53023  -5.40743  4.10905   1.000 58.94368  ? 43  ARG A C   1 
ATOM   301  O  O   . ARG A 1 44  ? -2.53505  -5.72263  4.75824   1.000 61.66562  ? 43  ARG A O   1 
ATOM   302  C  CB  . ARG A 1 44  ? -0.86332  -7.74022  3.46925   1.000 55.83440  ? 43  ARG A CB  1 
ATOM   303  C  CG  . ARG A 1 44  ? -1.00139  -8.81584  2.39038   1.000 61.14372  ? 43  ARG A CG  1 
ATOM   304  C  CD  . ARG A 1 44  ? -0.99184  -10.24239 2.97841   1.000 54.32207  ? 43  ARG A CD  1 
ATOM   305  N  NE  . ARG A 1 44  ? -2.29019  -10.64595 3.51041   1.000 58.65566  ? 43  ARG A NE  1 
ATOM   306  C  CZ  . ARG A 1 44  ? -2.54327  -11.82990 4.05652   1.000 56.42420  ? 43  ARG A CZ  1 
ATOM   307  N  NH1 . ARG A 1 44  ? -1.60166  -12.75287 4.18098   1.000 48.63323  ? 43  ARG A NH1 1 
ATOM   308  N  NH2 . ARG A 1 44  ? -3.77250  -12.09673 4.48760   1.000 57.32306  ? 43  ARG A NH2 1 
ATOM   309  N  N   . ASN A 1 45  ? -0.83613  -4.29152  4.33822   1.000 58.52105  ? 44  ASN A N   1 
ATOM   310  C  CA  . ASN A 1 45  ? -1.16121  -3.36479  5.41438   1.000 64.15309  ? 44  ASN A CA  1 
ATOM   311  C  C   . ASN A 1 45  ? -2.58796  -2.83841  5.32410   1.000 65.75488  ? 44  ASN A C   1 
ATOM   312  O  O   . ASN A 1 45  ? -3.20715  -2.55309  6.35614   1.000 66.10359  ? 44  ASN A O   1 
ATOM   313  C  CB  . ASN A 1 45  ? -0.16814  -2.20792  5.37691   1.000 59.88567  ? 44  ASN A CB  1 
ATOM   314  C  CG  . ASN A 1 45  ? 0.19300   -1.80314  3.95110   1.000 68.11473  ? 44  ASN A CG  1 
ATOM   315  O  OD1 . ASN A 1 45  ? -0.20016  -2.46787  2.98802   1.000 63.36517  ? 44  ASN A OD1 1 
ATOM   316  N  ND2 . ASN A 1 45  ? 0.94984   -0.71969  3.81163   1.000 68.06936  ? 44  ASN A ND2 1 
ATOM   317  N  N   . LYS A 1 46  ? -3.12731  -2.70294  4.11576   1.000 67.58272  ? 45  LYS A N   1 
ATOM   318  C  CA  . LYS A 1 46  ? -4.45135  -2.12382  3.94066   1.000 68.71872  ? 45  LYS A CA  1 
ATOM   319  C  C   . LYS A 1 46  ? -5.57411  -3.13718  4.13433   1.000 68.70147  ? 45  LYS A C   1 
ATOM   320  O  O   . LYS A 1 46  ? -6.73909  -2.80321  3.89405   1.000 69.43935  ? 45  LYS A O   1 
ATOM   321  C  CB  . LYS A 1 46  ? -4.55044  -1.45682  2.56680   1.000 72.66163  ? 45  LYS A CB  1 
ATOM   322  C  CG  . LYS A 1 46  ? -3.76358  -0.15737  2.49899   1.000 78.72020  ? 45  LYS A CG  1 
ATOM   323  C  CD  . LYS A 1 46  ? -4.07450  0.63128   1.24279   1.000 85.88420  ? 45  LYS A CD  1 
ATOM   324  C  CE  . LYS A 1 46  ? -3.46574  2.02526   1.31148   1.000 83.71693  ? 45  LYS A CE  1 
ATOM   325  N  NZ  . LYS A 1 46  ? -3.76625  2.84440   0.10295   1.000 94.36711  ? 45  LYS A NZ  1 
ATOM   326  N  N   . GLU A 1 47  ? -5.25239  -4.36407  4.54718   1.000 69.63322  ? 46  GLU A N   1 
ATOM   327  C  CA  . GLU A 1 47  ? -6.28409  -5.26341  5.04158   1.000 65.37489  ? 46  GLU A CA  1 
ATOM   328  C  C   . GLU A 1 47  ? -6.59158  -4.92219  6.49990   1.000 69.06371  ? 46  GLU A C   1 
ATOM   329  O  O   . GLU A 1 47  ? -5.68108  -4.57172  7.25706   1.000 74.27277  ? 46  GLU A O   1 
ATOM   330  C  CB  . GLU A 1 47  ? -5.83649  -6.71833  4.92639   1.000 68.30108  ? 46  GLU A CB  1 
ATOM   331  C  CG  . GLU A 1 47  ? -5.49998  -7.15062  3.50445   1.000 63.10531  ? 46  GLU A CG  1 
ATOM   332  C  CD  . GLU A 1 47  ? -4.91798  -8.54938  3.43747   1.000 65.20995  ? 46  GLU A CD  1 
ATOM   333  O  OE1 . GLU A 1 47  ? -5.00740  -9.28129  4.44666   1.000 61.07030  ? 46  GLU A OE1 1 
ATOM   334  O  OE2 . GLU A 1 47  ? -4.36744  -8.91783  2.37781   1.000 68.31533  ? 46  GLU A OE2 1 
ATOM   335  N  N   . PRO A 1 48  ? -7.86208  -4.99499  6.91229   1.000 68.71506  ? 47  PRO A N   1 
ATOM   336  C  CA  . PRO A 1 48  ? -8.22909  -4.48571  8.24941   1.000 73.87332  ? 47  PRO A CA  1 
ATOM   337  C  C   . PRO A 1 48  ? -7.47611  -5.13207  9.39803   1.000 79.97846  ? 47  PRO A C   1 
ATOM   338  O  O   . PRO A 1 48  ? -7.08990  -4.42872  10.34445  1.000 81.96796  ? 47  PRO A O   1 
ATOM   339  C  CB  . PRO A 1 48  ? -9.73490  -4.77301  8.32534   1.000 70.45453  ? 47  PRO A CB  1 
ATOM   340  C  CG  . PRO A 1 48  ? -10.17370 -4.83462  6.90351   1.000 60.87054  ? 47  PRO A CG  1 
ATOM   341  C  CD  . PRO A 1 48  ? -9.03637  -5.43462  6.14297   1.000 67.02880  ? 47  PRO A CD  1 
ATOM   342  N  N   . GLU A 1 49  ? -7.24931  -6.44799  9.34203   1.000 76.11585  ? 48  GLU A N   1 
ATOM   343  C  CA  . GLU A 1 49  ? -6.52593  -7.11695  10.42028  1.000 76.72684  ? 48  GLU A CA  1 
ATOM   344  C  C   . GLU A 1 49  ? -5.10350  -6.57837  10.54645  1.000 77.20184  ? 48  GLU A C   1 
ATOM   345  O  O   . GLU A 1 49  ? -4.64050  -6.25519  11.65122  1.000 76.67021  ? 48  GLU A O   1 
ATOM   346  C  CB  . GLU A 1 49  ? -6.50661  -8.63081  10.18970  1.000 71.71030  ? 48  GLU A CB  1 
ATOM   347  C  CG  . GLU A 1 49  ? -7.80842  -9.35758  10.52191  1.000 83.31561  ? 48  GLU A CG  1 
ATOM   348  C  CD  . GLU A 1 49  ? -8.74253  -9.48821  9.33206   1.000 95.26895  ? 48  GLU A CD  1 
ATOM   349  O  OE1 . GLU A 1 49  ? -8.53396  -8.78035  8.32198   1.000 90.73400  ? 48  GLU A OE1 1 
ATOM   350  O  OE2 . GLU A 1 49  ? -9.68654  -10.30489 9.40682   1.000 105.76066 ? 48  GLU A OE2 1 
ATOM   351  N  N   . VAL A 1 50  ? -4.39710  -6.46654  9.41738   1.000 63.55642  ? 49  VAL A N   1 
ATOM   352  C  CA  . VAL A 1 50  ? -3.01190  -6.00964  9.44961   1.000 64.26300  ? 49  VAL A CA  1 
ATOM   353  C  C   . VAL A 1 50  ? -2.93916  -4.56754  9.93595   1.000 80.52154  ? 49  VAL A C   1 
ATOM   354  O  O   . VAL A 1 50  ? -2.05578  -4.20938  10.72568  1.000 81.25074  ? 49  VAL A O   1 
ATOM   355  C  CB  . VAL A 1 50  ? -2.35800  -6.18384  8.06638   1.000 71.03637  ? 49  VAL A CB  1 
ATOM   356  C  CG1 . VAL A 1 50  ? -0.84116  -6.13989  8.18615   1.000 65.65480  ? 49  VAL A CG1 1 
ATOM   357  C  CG2 . VAL A 1 50  ? -2.80591  -7.49216  7.43272   1.000 66.48212  ? 49  VAL A CG2 1 
ATOM   358  N  N   . GLN A 1 51  ? -3.87543  -3.72250  9.49045   1.000 75.22036  ? 50  GLN A N   1 
ATOM   359  C  CA  . GLN A 1 51  ? -3.87413  -2.32847  9.92256   1.000 78.57758  ? 50  GLN A CA  1 
ATOM   360  C  C   . GLN A 1 51  ? -4.14790  -2.20899  11.41640  1.000 80.61322  ? 50  GLN A C   1 
ATOM   361  O  O   . GLN A 1 51  ? -3.57311  -1.34715  12.09372  1.000 84.81907  ? 50  GLN A O   1 
ATOM   362  C  CB  . GLN A 1 51  ? -4.89619  -1.52324  9.12071   1.000 80.25414  ? 50  GLN A CB  1 
ATOM   363  C  CG  . GLN A 1 51  ? -4.92819  -0.03877  9.46591   1.000 82.63653  ? 50  GLN A CG  1 
ATOM   364  C  CD  . GLN A 1 51  ? -3.56935  0.62460   9.34430   1.000 81.88033  ? 50  GLN A CD  1 
ATOM   365  O  OE1 . GLN A 1 51  ? -2.69120  0.15607   8.61724   1.000 82.44898  ? 50  GLN A OE1 1 
ATOM   366  N  NE2 . GLN A 1 51  ? -3.39034  1.72483   10.05947  1.000 74.09622  ? 50  GLN A NE2 1 
ATOM   367  N  N   . ARG A 1 52  ? -5.03062  -3.05642  11.94919  1.000 74.45917  ? 51  ARG A N   1 
ATOM   368  C  CA  . ARG A 1 52  ? -5.28562  -3.02969  13.38570  1.000 83.80231  ? 51  ARG A CA  1 
ATOM   369  C  C   . ARG A 1 52  ? -4.04976  -3.45888  14.17186  1.000 81.90545  ? 51  ARG A C   1 
ATOM   370  O  O   . ARG A 1 52  ? -3.63806  -2.78379  15.12380  1.000 87.89170  ? 51  ARG A O   1 
ATOM   371  C  CB  . ARG A 1 52  ? -6.48962  -3.91002  13.72246  1.000 81.46335  ? 51  ARG A CB  1 
ATOM   372  C  CG  . ARG A 1 52  ? -7.00976  -3.72453  15.13804  1.000 90.25528  ? 51  ARG A CG  1 
ATOM   373  C  CD  . ARG A 1 52  ? -6.90120  -2.26932  15.60302  1.000 101.82671 ? 51  ARG A CD  1 
ATOM   374  N  NE  . ARG A 1 52  ? -7.59681  -1.33763  14.72207  1.000 107.30745 ? 51  ARG A NE  1 
ATOM   375  C  CZ  . ARG A 1 52  ? -7.59665  -0.01983  14.87786  1.000 99.71913  ? 51  ARG A CZ  1 
ATOM   376  N  NH1 . ARG A 1 52  ? -6.95008  0.56035   15.87760  1.000 98.17753  ? 51  ARG A NH1 1 
ATOM   377  N  NH2 . ARG A 1 52  ? -8.26292  0.73637   14.01042  1.000 93.52239  ? 51  ARG A NH2 1 
ATOM   378  N  N   . LEU A 1 53  ? -3.43747  -4.58047  13.78100  1.000 81.27873  ? 52  LEU A N   1 
ATOM   379  C  CA  . LEU A 1 53  ? -2.23635  -5.04438  14.47009  1.000 81.86533  ? 52  LEU A CA  1 
ATOM   380  C  C   . LEU A 1 53  ? -1.07160  -4.06818  14.32933  1.000 79.51914  ? 52  LEU A C   1 
ATOM   381  O  O   . LEU A 1 53  ? -0.16458  -4.07917  15.16944  1.000 79.51329  ? 52  LEU A O   1 
ATOM   382  C  CB  . LEU A 1 53  ? -1.84255  -6.43358  13.95228  1.000 72.63530  ? 52  LEU A CB  1 
ATOM   383  C  CG  . LEU A 1 53  ? -2.90997  -7.52643  14.07753  1.000 72.14159  ? 52  LEU A CG  1 
ATOM   384  C  CD1 . LEU A 1 53  ? -2.39239  -8.87662  13.60615  1.000 73.66178  ? 52  LEU A CD1 1 
ATOM   385  C  CD2 . LEU A 1 53  ? -3.42055  -7.62932  15.50275  1.000 79.38970  ? 52  LEU A CD2 1 
ATOM   386  N  N   . LEU A 1 54  ? -1.08182  -3.22217  13.29904  1.000 82.62080  ? 53  LEU A N   1 
ATOM   387  C  CA  . LEU A 1 54  ? -0.04237  -2.22329  13.08224  1.000 82.61533  ? 53  LEU A CA  1 
ATOM   388  C  C   . LEU A 1 54  ? -0.35715  -0.88520  13.73761  1.000 87.77235  ? 53  LEU A C   1 
ATOM   389  O  O   . LEU A 1 54  ? 0.48795   0.01592   13.70983  1.000 90.97451  ? 53  LEU A O   1 
ATOM   390  C  CB  . LEU A 1 54  ? 0.18883   -2.01196  11.58126  1.000 80.35916  ? 53  LEU A CB  1 
ATOM   391  C  CG  . LEU A 1 54  ? 0.94456   -3.12458  10.85350  1.000 69.97193  ? 53  LEU A CG  1 
ATOM   392  C  CD1 . LEU A 1 54  ? 1.07724   -2.83563  9.36361   1.000 69.37850  ? 53  LEU A CD1 1 
ATOM   393  C  CD2 . LEU A 1 54  ? 2.30697   -3.32252  11.49044  1.000 76.48884  ? 53  LEU A CD2 1 
ATOM   394  N  N   . SER A 1 55  ? -1.54665  -0.73266  14.32233  1.000 90.35882  ? 54  SER A N   1 
ATOM   395  C  CA  . SER A 1 55  ? -1.89042  0.50794   15.00869  1.000 94.11898  ? 54  SER A CA  1 
ATOM   396  C  C   . SER A 1 55  ? -1.34023  0.53108   16.42822  1.000 99.71413  ? 54  SER A C   1 
ATOM   397  O  O   . SER A 1 55  ? -0.98883  1.59762   16.94646  1.000 97.43615  ? 54  SER A O   1 
ATOM   398  C  CB  . SER A 1 55  ? -3.40801  0.69371   15.02893  1.000 93.62826  ? 54  SER A CB  1 
ATOM   399  O  OG  . SER A 1 55  ? -3.79858  1.51541   16.11633  1.000 96.20454  ? 54  SER A OG  1 
ATOM   400  N  N   . GLU A 1 56  ? -1.26482  -0.63267  17.06591  1.000 95.18569  ? 55  GLU A N   1 
ATOM   401  C  CA  . GLU A 1 56  ? -0.85521  -0.72894  18.45922  1.000 95.37501  ? 55  GLU A CA  1 
ATOM   402  C  C   . GLU A 1 56  ? 0.66598   -0.69226  18.55472  1.000 94.64986  ? 55  GLU A C   1 
ATOM   403  O  O   . GLU A 1 56  ? 1.34769   -1.59170  18.05312  1.000 93.84803  ? 55  GLU A O   1 
ATOM   404  C  CB  . GLU A 1 56  ? -1.40871  -2.01357  19.07112  1.000 94.59849  ? 55  GLU A CB  1 
ATOM   405  C  CG  . GLU A 1 56  ? -2.83967  -2.32686  18.64770  1.000 94.20623  ? 55  GLU A CG  1 
ATOM   406  C  CD  . GLU A 1 56  ? -3.17471  -3.80101  18.75982  1.000 105.06253 ? 55  GLU A CD  1 
ATOM   407  O  OE1 . GLU A 1 56  ? -2.30475  -4.57397  19.21417  1.000 103.75319 ? 55  GLU A OE1 1 
ATOM   408  O  OE2 . GLU A 1 56  ? -4.30305  -4.19069  18.38983  1.000 107.34973 ? 55  GLU A OE2 1 
ATOM   409  N  N   . ASP A 1 57  ? 1.19856   0.34285   19.19546  1.000 93.35097  ? 56  ASP A N   1 
ATOM   410  C  CA  . ASP A 1 57  ? 2.62895   0.41032   19.45578  1.000 89.61696  ? 56  ASP A CA  1 
ATOM   411  C  C   . ASP A 1 57  ? 2.96502   -0.41048  20.69485  1.000 91.04353  ? 56  ASP A C   1 
ATOM   412  O  O   . ASP A 1 57  ? 2.21302   -0.42139  21.67333  1.000 85.23019  ? 56  ASP A O   1 
ATOM   413  C  CB  . ASP A 1 57  ? 3.07511   1.86379   19.64249  1.000 89.27627  ? 56  ASP A CB  1 
ATOM   414  C  CG  . ASP A 1 57  ? 2.69748   2.74861   18.46565  1.000 94.84427  ? 56  ASP A CG  1 
ATOM   415  O  OD1 . ASP A 1 57  ? 3.12802   2.45239   17.33143  1.000 94.70065  ? 56  ASP A OD1 1 
ATOM   416  O  OD2 . ASP A 1 57  ? 1.95640   3.73478   18.67093  1.000 100.35327 ? 56  ASP A OD2 1 
ATOM   417  N  N   . ASN A 1 58  ? 4.08930   -1.11848  20.64201  1.000 90.87347  ? 57  ASN A N   1 
ATOM   418  C  CA  . ASN A 1 58  ? 4.54412   -1.85639  21.80784  1.000 86.96177  ? 57  ASN A CA  1 
ATOM   419  C  C   . ASN A 1 58  ? 5.09519   -0.88953  22.85482  1.000 83.71317  ? 57  ASN A C   1 
ATOM   420  O  O   . ASN A 1 58  ? 5.26651   0.30769   22.60768  1.000 88.38836  ? 57  ASN A O   1 
ATOM   421  C  CB  . ASN A 1 58  ? 5.60502   -2.88625  21.41635  1.000 86.83732  ? 57  ASN A CB  1 
ATOM   422  C  CG  . ASN A 1 58  ? 6.74197   -2.27880  20.62505  1.000 93.11652  ? 57  ASN A CG  1 
ATOM   423  O  OD1 . ASN A 1 58  ? 7.43331   -1.37897  21.10023  1.000 97.76171  ? 57  ASN A OD1 1 
ATOM   424  N  ND2 . ASN A 1 58  ? 6.95098   -2.77876  19.41189  1.000 95.73792  ? 57  ASN A ND2 1 
ATOM   425  N  N   . GLN A 1 59  ? 5.35554   -1.42610  24.04770  1.000 90.04566  ? 58  GLN A N   1 
ATOM   426  C  CA  . GLN A 1 59  ? 5.98520   -0.63331  25.10338  1.000 83.46253  ? 58  GLN A CA  1 
ATOM   427  C  C   . GLN A 1 59  ? 7.33204   -0.06006  24.67853  1.000 83.39676  ? 58  GLN A C   1 
ATOM   428  O  O   . GLN A 1 59  ? 7.59361   1.12064   24.97229  1.000 81.97831  ? 58  GLN A O   1 
ATOM   429  C  CB  . GLN A 1 59  ? 6.10699   -1.47973  26.37775  1.000 79.34430  ? 58  GLN A CB  1 
ATOM   430  C  CG  . GLN A 1 59  ? 7.30513   -1.12109  27.24984  1.000 79.44415  ? 58  GLN A CG  1 
ATOM   431  C  CD  . GLN A 1 59  ? 7.64595   -2.18801  28.27516  1.000 82.05144  ? 58  GLN A CD  1 
ATOM   432  O  OE1 . GLN A 1 59  ? 6.85912   -2.47135  29.17810  1.000 82.46392  ? 58  GLN A OE1 1 
ATOM   433  N  NE2 . GLN A 1 59  ? 8.82920   -2.78519  28.13955  1.000 80.59964  ? 58  GLN A NE2 1 
ATOM   434  N  N   . PRO A 1 60  ? 8.22545   -0.80607  24.01531  1.000 86.40025  ? 59  PRO A N   1 
ATOM   435  C  CA  . PRO A 1 60  ? 9.47721   -0.18795  23.54594  1.000 84.51053  ? 59  PRO A CA  1 
ATOM   436  C  C   . PRO A 1 60  ? 9.27733   1.01764   22.64452  1.000 81.96644  ? 59  PRO A C   1 
ATOM   437  O  O   . PRO A 1 60  ? 10.14078  1.90235   22.61984  1.000 73.23130  ? 59  PRO A O   1 
ATOM   438  C  CB  . PRO A 1 60  ? 10.16735  -1.34043  22.80654  1.000 77.52221  ? 59  PRO A CB  1 
ATOM   439  C  CG  . PRO A 1 60  ? 9.71546   -2.54592  23.53378  1.000 79.21158  ? 59  PRO A CG  1 
ATOM   440  C  CD  . PRO A 1 60  ? 8.28357   -2.27832  23.91072  1.000 83.67635  ? 59  PRO A CD  1 
ATOM   441  N  N   . GLN A 1 61  ? 8.17372   1.08233   21.89774  1.000 84.86351  ? 60  GLN A N   1 
ATOM   442  C  CA  . GLN A 1 61  ? 7.91789   2.24361   21.05109  1.000 82.39758  ? 60  GLN A CA  1 
ATOM   443  C  C   . GLN A 1 61  ? 7.42574   3.43354   21.86367  1.000 83.14809  ? 60  GLN A C   1 
ATOM   444  O  O   . GLN A 1 61  ? 7.91859   4.55884   21.69268  1.000 79.61703  ? 60  GLN A O   1 
ATOM   445  C  CB  . GLN A 1 61  ? 6.88159   1.90082   19.98174  1.000 85.76373  ? 60  GLN A CB  1 
ATOM   446  C  CG  . GLN A 1 61  ? 7.31098   0.83016   19.00191  1.000 88.94619  ? 60  GLN A CG  1 
ATOM   447  C  CD  . GLN A 1 61  ? 6.17761   0.40290   18.09389  1.000 89.55217  ? 60  GLN A CD  1 
ATOM   448  O  OE1 . GLN A 1 61  ? 5.74539   -0.75089  18.11645  1.000 86.05363  ? 60  GLN A OE1 1 
ATOM   449  N  NE2 . GLN A 1 61  ? 5.68291   1.33820   17.29068  1.000 85.11927  ? 60  GLN A NE2 1 
ATOM   450  N  N   . LYS A 1 62  ? 6.44241   3.20304   22.73720  1.000 81.39481  ? 61  LYS A N   1 
ATOM   451  C  CA  . LYS A 1 62  ? 5.87566   4.30010   23.50701  1.000 78.04319  ? 61  LYS A CA  1 
ATOM   452  C  C   . LYS A 1 62  ? 6.90455   4.88239   24.46458  1.000 72.69875  ? 61  LYS A C   1 
ATOM   453  O  O   . LYS A 1 62  ? 6.90251   6.09252   24.70793  1.000 72.88667  ? 61  LYS A O   1 
ATOM   454  C  CB  . LYS A 1 62  ? 4.62780   3.82102   24.25027  1.000 82.06835  ? 61  LYS A CB  1 
ATOM   455  C  CG  . LYS A 1 62  ? 3.49411   3.39757   23.31617  1.000 86.37915  ? 61  LYS A CG  1 
ATOM   456  C  CD  . LYS A 1 62  ? 2.30950   2.79313   24.06010  1.000 86.35561  ? 61  LYS A CD  1 
ATOM   457  C  CE  . LYS A 1 62  ? 2.67549   1.45987   24.68727  1.000 80.48192  ? 61  LYS A CE  1 
ATOM   458  N  NZ  . LYS A 1 62  ? 1.48185   0.78648   25.26459  1.000 80.93061  ? 61  LYS A NZ  1 
ATOM   459  N  N   . ILE A 1 63  ? 7.81082   4.04704   24.98147  1.000 73.78911  ? 62  ILE A N   1 
ATOM   460  C  CA  . ILE A 1 63  ? 8.89313   4.54236   25.82872  1.000 68.99278  ? 62  ILE A CA  1 
ATOM   461  C  C   . ILE A 1 63  ? 9.72868   5.56612   25.06849  1.000 72.17916  ? 62  ILE A C   1 
ATOM   462  O  O   . ILE A 1 63  ? 9.97011   6.68130   25.54913  1.000 69.37525  ? 62  ILE A O   1 
ATOM   463  C  CB  . ILE A 1 63  ? 9.75550   3.36737   26.33062  1.000 74.11825  ? 62  ILE A CB  1 
ATOM   464  C  CG1 . ILE A 1 63  ? 9.01619   2.56480   27.40610  1.000 70.65828  ? 62  ILE A CG1 1 
ATOM   465  C  CG2 . ILE A 1 63  ? 11.09112  3.86438   26.86263  1.000 72.50603  ? 62  ILE A CG2 1 
ATOM   466  C  CD1 . ILE A 1 63  ? 9.80054   1.37493   27.93305  1.000 72.91239  ? 62  ILE A CD1 1 
ATOM   467  N  N   . GLY A 1 64  ? 10.15806  5.20776   23.85439  1.000 74.39983  ? 63  GLY A N   1 
ATOM   468  C  CA  . GLY A 1 64  ? 10.99595  6.10514   23.07387  1.000 69.46255  ? 63  GLY A CA  1 
ATOM   469  C  C   . GLY A 1 64  ? 10.27643  7.37318   22.65873  1.000 67.27892  ? 63  GLY A C   1 
ATOM   470  O  O   . GLY A 1 64  ? 10.85700  8.46328   22.67567  1.000 82.63345  ? 63  GLY A O   1 
ATOM   471  N  N   . LYS A 1 65  ? 9.00400   7.25028   22.27085  1.000 68.46290  ? 64  LYS A N   1 
ATOM   472  C  CA  . LYS A 1 65  ? 8.25988   8.43406   21.84524  1.000 71.34820  ? 64  LYS A CA  1 
ATOM   473  C  C   . LYS A 1 65  ? 8.02943   9.38775   23.01531  1.000 68.04782  ? 64  LYS A C   1 
ATOM   474  O  O   . LYS A 1 65  ? 8.16315   10.61637  22.87129  1.000 74.43045  ? 64  LYS A O   1 
ATOM   475  C  CB  . LYS A 1 65  ? 6.94029   8.01196   21.19687  1.000 70.55883  ? 64  LYS A CB  1 
ATOM   476  C  CG  . LYS A 1 65  ? 7.14313   7.14024   19.96121  1.000 78.08248  ? 64  LYS A CG  1 
ATOM   477  C  CD  . LYS A 1 65  ? 5.84544   6.83906   19.22308  1.000 79.41541  ? 64  LYS A CD  1 
ATOM   478  C  CE  . LYS A 1 65  ? 6.13854   6.19481   17.87213  1.000 84.25688  ? 64  LYS A CE  1 
ATOM   479  N  NZ  . LYS A 1 65  ? 4.93243   6.11208   17.00203  1.000 86.41469  ? 64  LYS A NZ  1 
ATOM   480  N  N   . LEU A 1 66  ? 7.71677   8.83551   24.19161  1.000 69.41947  ? 65  LEU A N   1 
ATOM   481  C  CA  . LEU A 1 66  ? 7.59226   9.65617   25.38862  1.000 68.33786  ? 65  LEU A CA  1 
ATOM   482  C  C   . LEU A 1 66  ? 8.90961   10.33622  25.72592  1.000 64.27066  ? 65  LEU A C   1 
ATOM   483  O  O   . LEU A 1 66  ? 8.92465   11.49394  26.15018  1.000 65.55188  ? 65  LEU A O   1 
ATOM   484  C  CB  . LEU A 1 66  ? 7.12172   8.80284   26.56335  1.000 68.55912  ? 65  LEU A CB  1 
ATOM   485  C  CG  . LEU A 1 66  ? 5.66390   8.34337   26.58191  1.000 69.86135  ? 65  LEU A CG  1 
ATOM   486  C  CD1 . LEU A 1 66  ? 5.44267   7.34002   27.69784  1.000 66.44966  ? 65  LEU A CD1 1 
ATOM   487  C  CD2 . LEU A 1 66  ? 4.72769   9.52883   26.73974  1.000 64.47653  ? 65  LEU A CD2 1 
ATOM   488  N  N   . ALA A 1 67  ? 10.03085  9.63365   25.54220  1.000 61.73778  ? 66  ALA A N   1 
ATOM   489  C  CA  . ALA A 1 67  ? 11.32759  10.24553  25.82268  1.000 61.25989  ? 66  ALA A CA  1 
ATOM   490  C  C   . ALA A 1 67  ? 11.65407  11.37539  24.84976  1.000 65.04517  ? 66  ALA A C   1 
ATOM   491  O  O   . ALA A 1 67  ? 12.26506  12.38121  25.24563  1.000 66.08783  ? 66  ALA A O   1 
ATOM   492  C  CB  . ALA A 1 67  ? 12.42454  9.18481   25.78583  1.000 63.51138  ? 66  ALA A CB  1 
ATOM   493  N  N   . GLN A 1 68  ? 11.28817  11.21828  23.57446  1.000 68.85765  ? 67  GLN A N   1 
ATOM   494  C  CA  . GLN A 1 68  ? 11.50066  12.29960  22.61656  1.000 66.54618  ? 67  GLN A CA  1 
ATOM   495  C  C   . GLN A 1 68  ? 10.69711  13.52978  23.01122  1.000 60.82242  ? 67  GLN A C   1 
ATOM   496  O  O   . GLN A 1 68  ? 11.22808  14.65355  23.04959  1.000 66.15862  ? 67  GLN A O   1 
ATOM   497  C  CB  . GLN A 1 68  ? 11.11770  11.84222  21.20946  1.000 64.78142  ? 67  GLN A CB  1 
ATOM   498  C  CG  . GLN A 1 68  ? 11.43525  12.84640  20.11740  1.000 59.86193  ? 67  GLN A CG  1 
ATOM   499  C  CD  . GLN A 1 68  ? 12.92684  12.97924  19.86683  1.000 55.87178  ? 67  GLN A CD  1 
ATOM   500  O  OE1 . GLN A 1 68  ? 13.70427  12.08645  20.19832  1.000 62.11373  ? 67  GLN A OE1 1 
ATOM   501  N  NE2 . GLN A 1 68  ? 13.33223  14.09675  19.27746  1.000 56.05828  ? 67  GLN A NE2 1 
ATOM   502  N  N   . ARG A 1 69  ? 9.41743   13.32916  23.34737  1.000 59.47575  ? 68  ARG A N   1 
ATOM   503  C  CA  . ARG A 1 69  ? 8.63645   14.45072  23.85329  1.000 68.37470  ? 68  ARG A CA  1 
ATOM   504  C  C   . ARG A 1 69  ? 9.23845   14.99817  25.14353  1.000 65.62299  ? 68  ARG A C   1 
ATOM   505  O  O   . ARG A 1 69  ? 9.13584   16.19604  25.41485  1.000 66.23705  ? 68  ARG A O   1 
ATOM   506  C  CB  . ARG A 1 69  ? 7.18334   14.03225  24.06937  1.000 71.26951  ? 68  ARG A CB  1 
ATOM   507  C  CG  . ARG A 1 69  ? 6.29227   15.14567  24.60652  1.000 71.75347  ? 68  ARG A CG  1 
ATOM   508  C  CD  . ARG A 1 69  ? 5.76860   16.05597  23.52206  1.000 77.12006  ? 68  ARG A CD  1 
ATOM   509  N  NE  . ARG A 1 69  ? 4.82156   17.04341  24.02917  1.000 84.64704  ? 68  ARG A NE  1 
ATOM   510  C  CZ  . ARG A 1 69  ? 3.58273   16.76650  24.41779  1.000 90.89381  ? 68  ARG A CZ  1 
ATOM   511  N  NH1 . ARG A 1 69  ? 3.10994   15.52917  24.40181  1.000 91.91027  ? 68  ARG A NH1 1 
ATOM   512  N  NH2 . ARG A 1 69  ? 2.80081   17.75380  24.84518  1.000 92.12683  ? 68  ARG A NH2 1 
ATOM   513  N  N   . GLY A 1 70  ? 9.87306   14.14486  25.94079  1.000 66.96818  ? 69  GLY A N   1 
ATOM   514  C  CA  . GLY A 1 70  ? 10.52361  14.56724  27.16313  1.000 62.91585  ? 69  GLY A CA  1 
ATOM   515  C  C   . GLY A 1 70  ? 11.64144  15.56258  26.94955  1.000 67.05209  ? 69  GLY A C   1 
ATOM   516  O  O   . GLY A 1 70  ? 11.67541  16.61215  27.59848  1.000 70.19878  ? 69  GLY A O   1 
ATOM   517  N  N   . VAL A 1 71  ? 12.57406  15.23778  26.05102  1.000 61.15520  ? 70  VAL A N   1 
ATOM   518  C  CA  . VAL A 1 71  ? 13.65167  16.18736  25.76233  1.000 69.02811  ? 70  VAL A CA  1 
ATOM   519  C  C   . VAL A 1 71  ? 13.07621  17.45069  25.12844  1.000 67.97035  ? 70  VAL A C   1 
ATOM   520  O  O   . VAL A 1 71  ? 13.49475  18.57790  25.44821  1.000 67.09377  ? 70  VAL A O   1 
ATOM   521  C  CB  . VAL A 1 71  ? 14.75645  15.54473  24.89439  1.000 63.61360  ? 70  VAL A CB  1 
ATOM   522  C  CG1 . VAL A 1 71  ? 15.36951  14.35124  25.61884  1.000 60.04485  ? 70  VAL A CG1 1 
ATOM   523  C  CG2 . VAL A 1 71  ? 14.23384  15.14551  23.52523  1.000 78.63636  ? 70  VAL A CG2 1 
ATOM   524  N  N   . PHE A 1 72  ? 12.06533  17.28714  24.26575  1.000 67.94256  ? 71  PHE A N   1 
ATOM   525  C  CA  . PHE A 1 72  ? 11.43631  18.44290  23.63419  1.000 68.03932  ? 71  PHE A CA  1 
ATOM   526  C  C   . PHE A 1 72  ? 10.85816  19.38955  24.68102  1.000 66.15379  ? 71  PHE A C   1 
ATOM   527  O  O   . PHE A 1 72  ? 11.06674  20.60693  24.61888  1.000 71.31532  ? 71  PHE A O   1 
ATOM   528  C  CB  . PHE A 1 72  ? 10.35450  17.97113  22.65794  1.000 67.32488  ? 71  PHE A CB  1 
ATOM   529  C  CG  . PHE A 1 72  ? 9.61614   19.09059  21.97449  1.000 65.61478  ? 71  PHE A CG  1 
ATOM   530  C  CD1 . PHE A 1 72  ? 10.14166  19.70057  20.84761  1.000 64.27334  ? 71  PHE A CD1 1 
ATOM   531  C  CD2 . PHE A 1 72  ? 8.39053   19.52541  22.45395  1.000 69.19553  ? 71  PHE A CD2 1 
ATOM   532  C  CE1 . PHE A 1 72  ? 9.45917   20.73145  20.21479  1.000 70.39909  ? 71  PHE A CE1 1 
ATOM   533  C  CE2 . PHE A 1 72  ? 7.70382   20.55285  21.82701  1.000 71.82990  ? 71  PHE A CE2 1 
ATOM   534  C  CZ  . PHE A 1 72  ? 8.23856   21.15719  20.70669  1.000 71.12517  ? 71  PHE A CZ  1 
ATOM   535  N  N   . GLU A 1 73  ? 10.15555  18.83701  25.67323  1.000 66.49139  ? 72  GLU A N   1 
ATOM   536  C  CA  . GLU A 1 73  ? 9.56096   19.65105  26.72901  1.000 72.59619  ? 72  GLU A CA  1 
ATOM   537  C  C   . GLU A 1 73  ? 10.62897  20.28643  27.60516  1.000 69.22617  ? 72  GLU A C   1 
ATOM   538  O  O   . GLU A 1 73  ? 10.54794  21.47519  27.93333  1.000 71.13838  ? 72  GLU A O   1 
ATOM   539  C  CB  . GLU A 1 73  ? 8.61470   18.80594  27.57970  1.000 74.45876  ? 72  GLU A CB  1 
ATOM   540  C  CG  . GLU A 1 73  ? 7.38686   18.32796  26.83900  1.000 71.15383  ? 72  GLU A CG  1 
ATOM   541  C  CD  . GLU A 1 73  ? 6.66481   19.44513  26.10651  1.000 75.72822  ? 72  GLU A CD  1 
ATOM   542  O  OE1 . GLU A 1 73  ? 6.57903   20.56999  26.64909  1.000 75.42478  ? 72  GLU A OE1 1 
ATOM   543  O  OE2 . GLU A 1 73  ? 6.16878   19.19026  24.98903  1.000 78.56653  ? 72  GLU A OE2 1 
ATOM   544  N  N   . PHE A 1 74  ? 11.63753  19.50277  28.00008  1.000 67.66268  ? 73  PHE A N   1 
ATOM   545  C  CA  . PHE A 1 74  ? 12.73250  20.03710  28.80148  1.000 62.00681  ? 73  PHE A CA  1 
ATOM   546  C  C   . PHE A 1 74  ? 13.36104  21.24418  28.13099  1.000 64.37153  ? 73  PHE A C   1 
ATOM   547  O  O   . PHE A 1 74  ? 13.88529  22.13543  28.81062  1.000 77.23644  ? 73  PHE A O   1 
ATOM   548  C  CB  . PHE A 1 74  ? 13.79730  18.96021  29.02878  1.000 60.40322  ? 73  PHE A CB  1 
ATOM   549  C  CG  . PHE A 1 74  ? 13.58576  18.13841  30.26890  1.000 65.56299  ? 73  PHE A CG  1 
ATOM   550  C  CD1 . PHE A 1 74  ? 13.23801  18.73756  31.47140  1.000 65.86904  ? 73  PHE A CD1 1 
ATOM   551  C  CD2 . PHE A 1 74  ? 13.75646  16.76481  30.23373  1.000 60.20420  ? 73  PHE A CD2 1 
ATOM   552  C  CE1 . PHE A 1 74  ? 13.05867  17.97550  32.61157  1.000 63.15557  ? 73  PHE A CE1 1 
ATOM   553  C  CE2 . PHE A 1 74  ? 13.57805  15.99795  31.36738  1.000 63.91537  ? 73  PHE A CE2 1 
ATOM   554  C  CZ  . PHE A 1 74  ? 13.22661  16.60538  32.56050  1.000 67.20274  ? 73  PHE A CZ  1 
ATOM   555  N  N   . HIS A 1 75  ? 13.32014  21.29158  26.80020  1.000 66.97184  ? 74  HIS A N   1 
ATOM   556  C  CA  . HIS A 1 75  ? 13.88625  22.42970  26.09174  1.000 66.31966  ? 74  HIS A CA  1 
ATOM   557  C  C   . HIS A 1 75  ? 12.86135  23.48062  25.66866  1.000 64.46112  ? 74  HIS A C   1 
ATOM   558  O  O   . HIS A 1 75  ? 13.26516  24.55063  25.20022  1.000 61.30044  ? 74  HIS A O   1 
ATOM   559  C  CB  . HIS A 1 75  ? 14.67583  21.93669  24.87667  1.000 61.22317  ? 74  HIS A CB  1 
ATOM   560  C  CG  . HIS A 1 75  ? 15.96239  21.26740  25.24448  1.000 52.83728  ? 74  HIS A CG  1 
ATOM   561  N  ND1 . HIS A 1 75  ? 17.17691  21.91679  25.19844  1.000 57.19595  ? 74  HIS A ND1 1 
ATOM   562  C  CD2 . HIS A 1 75  ? 16.22063  20.01932  25.70089  1.000 54.22789  ? 74  HIS A CD2 1 
ATOM   563  C  CE1 . HIS A 1 75  ? 18.13083  21.09282  25.59261  1.000 53.75203  ? 74  HIS A CE1 1 
ATOM   564  N  NE2 . HIS A 1 75  ? 17.57703  19.93490  25.90418  1.000 54.08917  ? 74  HIS A NE2 1 
ATOM   565  N  N   . GLN A 1 76  ? 11.55817  23.22192  25.82225  1.000 65.03865  ? 75  GLN A N   1 
ATOM   566  C  CA  . GLN A 1 76  ? 10.58240  24.27675  25.54768  1.000 68.51174  ? 75  GLN A CA  1 
ATOM   567  C  C   . GLN A 1 76  ? 10.56133  25.32279  26.65809  1.000 71.50021  ? 75  GLN A C   1 
ATOM   568  O  O   . GLN A 1 76  ? 10.54935  26.52819  26.38218  1.000 81.62724  ? 75  GLN A O   1 
ATOM   569  C  CB  . GLN A 1 76  ? 9.18389   23.68702  25.36142  1.000 70.89514  ? 75  GLN A CB  1 
ATOM   570  C  CG  . GLN A 1 76  ? 9.02045   22.81422  24.13289  1.000 73.03308  ? 75  GLN A CG  1 
ATOM   571  C  CD  . GLN A 1 76  ? 9.61744   23.42973  22.88542  1.000 69.18629  ? 75  GLN A CD  1 
ATOM   572  O  OE1 . GLN A 1 76  ? 10.67761  23.00900  22.41828  1.000 79.24113  ? 75  GLN A OE1 1 
ATOM   573  N  NE2 . GLN A 1 76  ? 8.93304   24.42141  22.32935  1.000 59.79143  ? 75  GLN A NE2 1 
ATOM   574  N  N   . GLU A 1 77  ? 10.56515  24.88426  27.91443  1.000 80.95141  ? 76  GLU A N   1 
ATOM   575  C  CA  . GLU A 1 77  ? 10.67304  25.77173  29.07121  1.000 77.30077  ? 76  GLU A CA  1 
ATOM   576  C  C   . GLU A 1 77  ? 11.95056  25.37656  29.80341  1.000 66.56473  ? 76  GLU A C   1 
ATOM   577  O  O   . GLU A 1 77  ? 11.95277  24.44466  30.61030  1.000 65.17200  ? 76  GLU A O   1 
ATOM   578  C  CB  . GLU A 1 77  ? 9.44624   25.67729  29.97651  1.000 75.76777  ? 76  GLU A CB  1 
ATOM   579  C  CG  . GLU A 1 77  ? 8.14039   26.07728  29.30902  1.000 78.32961  ? 76  GLU A CG  1 
ATOM   580  C  CD  . GLU A 1 77  ? 8.14503   27.51191  28.82069  1.000 85.18797  ? 76  GLU A CD  1 
ATOM   581  O  OE1 . GLU A 1 77  ? 8.72310   28.37519  29.51227  1.000 79.79313  ? 76  GLU A OE1 1 
ATOM   582  O  OE2 . GLU A 1 77  ? 7.57297   27.77778  27.74208  1.000 83.61568  ? 76  GLU A OE2 1 
ATOM   583  N  N   . LEU A 1 78  ? 13.03900  26.09718  29.52108  1.000 61.52317  ? 77  LEU A N   1 
ATOM   584  C  CA  . LEU A 1 78  ? 14.34912  25.70229  30.02495  1.000 59.83954  ? 77  LEU A CA  1 
ATOM   585  C  C   . LEU A 1 78  ? 14.39942  25.69245  31.54429  1.000 69.67621  ? 77  LEU A C   1 
ATOM   586  O  O   . LEU A 1 78  ? 15.27743  25.04110  32.12097  1.000 67.91544  ? 77  LEU A O   1 
ATOM   587  C  CB  . LEU A 1 78  ? 15.43022  26.63115  29.46523  1.000 56.62178  ? 77  LEU A CB  1 
ATOM   588  C  CG  . LEU A 1 78  ? 16.60810  25.93122  28.77832  1.000 62.21787  ? 77  LEU A CG  1 
ATOM   589  C  CD1 . LEU A 1 78  ? 16.12365  25.10289  27.59966  1.000 64.46608  ? 77  LEU A CD1 1 
ATOM   590  C  CD2 . LEU A 1 78  ? 17.67045  26.92772  28.33195  1.000 67.57990  ? 77  LEU A CD2 1 
ATOM   591  N  N   . VAL A 1 79  ? 13.45447  26.36762  32.20399  1.000 68.86516  ? 78  VAL A N   1 
ATOM   592  C  CA  . VAL A 1 79  ? 13.39782  26.33852  33.66170  1.000 67.66246  ? 78  VAL A CA  1 
ATOM   593  C  C   . VAL A 1 79  ? 13.33597  24.90382  34.16324  1.000 67.46972  ? 78  VAL A C   1 
ATOM   594  O  O   . VAL A 1 79  ? 13.82802  24.59445  35.25739  1.000 70.03158  ? 78  VAL A O   1 
ATOM   595  C  CB  . VAL A 1 79  ? 12.19729  27.16984  34.16639  1.000 73.92277  ? 78  VAL A CB  1 
ATOM   596  C  CG1 . VAL A 1 79  ? 11.94153  28.36037  33.23277  1.000 76.72344  ? 78  VAL A CG1 1 
ATOM   597  C  CG2 . VAL A 1 79  ? 10.94084  26.30500  34.32814  1.000 70.96989  ? 78  VAL A CG2 1 
ATOM   598  N  N   . ARG A 1 80  ? 12.77906  23.99618  33.35706  1.000 60.80575  ? 79  ARG A N   1 
ATOM   599  C  CA  . ARG A 1 80  ? 12.59182  22.61484  33.77164  1.000 61.94802  ? 79  ARG A CA  1 
ATOM   600  C  C   . ARG A 1 80  ? 13.90476  21.85213  33.87284  1.000 58.58870  ? 79  ARG A C   1 
ATOM   601  O  O   . ARG A 1 80  ? 13.89881  20.70217  34.32312  1.000 62.72465  ? 79  ARG A O   1 
ATOM   602  C  CB  . ARG A 1 80  ? 11.62796  21.91572  32.81206  1.000 71.63100  ? 79  ARG A CB  1 
ATOM   603  C  CG  . ARG A 1 80  ? 10.27812  22.62515  32.69532  1.000 73.93173  ? 79  ARG A CG  1 
ATOM   604  C  CD  . ARG A 1 80  ? 9.22567   21.75499  32.04092  1.000 76.13905  ? 79  ARG A CD  1 
ATOM   605  N  NE  . ARG A 1 80  ? 9.02148   22.07175  30.63307  1.000 89.29535  ? 79  ARG A NE  1 
ATOM   606  C  CZ  . ARG A 1 80  ? 7.92943   22.64889  30.14915  1.000 80.54151  ? 79  ARG A CZ  1 
ATOM   607  N  NH1 . ARG A 1 80  ? 6.93223   23.01745  30.93922  1.000 80.60118  ? 79  ARG A NH1 1 
ATOM   608  N  NH2 . ARG A 1 80  ? 7.82780   22.84841  28.83828  1.000 80.03543  ? 79  ARG A NH2 1 
ATOM   609  N  N   . LEU A 1 81  ? 15.02194  22.45716  33.46381  1.000 63.22373  ? 80  LEU A N   1 
ATOM   610  C  CA  . LEU A 1 81  ? 16.33985  21.93571  33.78791  1.000 66.30703  ? 80  LEU A CA  1 
ATOM   611  C  C   . LEU A 1 81  ? 17.05526  22.75841  34.85014  1.000 71.65721  ? 80  LEU A C   1 
ATOM   612  O  O   . LEU A 1 81  ? 17.90341  22.21099  35.56288  1.000 71.31779  ? 80  LEU A O   1 
ATOM   613  C  CB  . LEU A 1 81  ? 17.21661  21.87124  32.52800  1.000 62.23136  ? 80  LEU A CB  1 
ATOM   614  C  CG  . LEU A 1 81  ? 16.68423  20.99885  31.38414  1.000 63.03494  ? 80  LEU A CG  1 
ATOM   615  C  CD1 . LEU A 1 81  ? 17.41033  21.28419  30.07259  1.000 58.84814  ? 80  LEU A CD1 1 
ATOM   616  C  CD2 . LEU A 1 81  ? 16.77986  19.51768  31.74030  1.000 61.16702  ? 80  LEU A CD2 1 
ATOM   617  N  N   . SER A 1 82  ? 16.71750  24.04669  34.98982  1.000 67.24308  ? 81  SER A N   1 
ATOM   618  C  CA  . SER A 1 82  ? 17.35517  24.90571  35.98161  1.000 71.14325  ? 81  SER A CA  1 
ATOM   619  C  C   . SER A 1 82  ? 16.64980  24.86693  37.32714  1.000 66.99641  ? 81  SER A C   1 
ATOM   620  O  O   . SER A 1 82  ? 17.29353  25.07637  38.35912  1.000 63.62172  ? 81  SER A O   1 
ATOM   621  C  CB  . SER A 1 82  ? 17.40652  26.35148  35.48306  1.000 68.14769  ? 81  SER A CB  1 
ATOM   622  O  OG  . SER A 1 82  ? 16.10498  26.87930  35.32277  1.000 69.54552  ? 81  SER A OG  1 
ATOM   623  N  N   . GLY A 1 83  ? 15.34057  24.60833  37.34076  1.000 71.04946  ? 82  GLY A N   1 
ATOM   624  C  CA  . GLY A 1 83  ? 14.60161  24.47164  38.57634  1.000 66.14743  ? 82  GLY A CA  1 
ATOM   625  C  C   . GLY A 1 83  ? 14.72380  23.07627  39.15795  1.000 71.39777  ? 82  GLY A C   1 
ATOM   626  O  O   . GLY A 1 83  ? 15.34672  22.18152  38.58770  1.000 75.61248  ? 82  GLY A O   1 
ATOM   627  N  N   . SER A 1 84  ? 14.09290  22.89491  40.31644  1.000 72.48753  ? 83  SER A N   1 
ATOM   628  C  CA  . SER A 1 84  ? 14.20928  21.66400  41.08628  1.000 72.86467  ? 83  SER A CA  1 
ATOM   629  C  C   . SER A 1 84  ? 13.04872  20.70058  40.87382  1.000 70.69033  ? 83  SER A C   1 
ATOM   630  O  O   . SER A 1 84  ? 13.05607  19.61039  41.45455  1.000 73.98886  ? 83  SER A O   1 
ATOM   631  C  CB  . SER A 1 84  ? 14.32831  21.98594  42.57799  1.000 69.56730  ? 83  SER A CB  1 
ATOM   632  O  OG  . SER A 1 84  ? 15.64118  22.40350  42.91290  1.000 64.45059  ? 83  SER A OG  1 
ATOM   633  N  N   . HIS A 1 85  ? 12.05586  21.06471  40.06259  1.000 67.85726  ? 84  HIS A N   1 
ATOM   634  C  CA  . HIS A 1 85  ? 10.86758  20.24089  39.88346  1.000 77.21073  ? 84  HIS A CA  1 
ATOM   635  C  C   . HIS A 1 85  ? 10.63116  19.83269  38.43670  1.000 79.22162  ? 84  HIS A C   1 
ATOM   636  O  O   . HIS A 1 85  ? 9.60966   19.19747  38.14759  1.000 79.25910  ? 84  HIS A O   1 
ATOM   637  C  CB  . HIS A 1 85  ? 9.63510   20.97593  40.42167  1.000 76.65075  ? 84  HIS A CB  1 
ATOM   638  C  CG  . HIS A 1 85  ? 9.85756   21.60833  41.75972  1.000 80.97573  ? 84  HIS A CG  1 
ATOM   639  N  ND1 . HIS A 1 85  ? 10.13635  20.87409  42.89258  1.000 78.22959  ? 84  HIS A ND1 1 
ATOM   640  C  CD2 . HIS A 1 85  ? 9.86087   22.90668  42.14344  1.000 74.47319  ? 84  HIS A CD2 1 
ATOM   641  C  CE1 . HIS A 1 85  ? 10.29458  21.69188  43.91792  1.000 74.93599  ? 84  HIS A CE1 1 
ATOM   642  N  NE2 . HIS A 1 85  ? 10.13203  22.93094  43.49033  1.000 78.20909  ? 84  HIS A NE2 1 
ATOM   643  N  N   . GLY A 1 86  ? 11.54388  20.18069  37.52950  1.000 83.00579  ? 85  GLY A N   1 
ATOM   644  C  CA  . GLY A 1 86  ? 11.44465  19.92022  36.10455  1.000 76.59113  ? 85  GLY A CA  1 
ATOM   645  C  C   . GLY A 1 86  ? 11.00762  18.53281  35.68622  1.000 76.30278  ? 85  GLY A C   1 
ATOM   646  O  O   . GLY A 1 86  ? 10.07770  18.39565  34.88879  1.000 79.50513  ? 85  GLY A O   1 
ATOM   647  N  N   . VAL A 1 87  ? 11.70393  17.50133  36.17397  1.000 74.20139  ? 86  VAL A N   1 
ATOM   648  C  CA  . VAL A 1 87  ? 11.35894  16.12417  35.82069  1.000 75.29295  ? 86  VAL A CA  1 
ATOM   649  C  C   . VAL A 1 87  ? 9.89913   15.84339  36.13759  1.000 80.99181  ? 86  VAL A C   1 
ATOM   650  O  O   . VAL A 1 87  ? 9.17732   15.23509  35.33627  1.000 86.98719  ? 86  VAL A O   1 
ATOM   651  C  CB  . VAL A 1 87  ? 12.29288  15.13507  36.54567  1.000 74.93130  ? 86  VAL A CB  1 
ATOM   652  C  CG1 . VAL A 1 87  ? 11.64959  13.75722  36.66350  1.000 73.07549  ? 86  VAL A CG1 1 
ATOM   653  C  CG2 . VAL A 1 87  ? 13.61081  15.02987  35.81216  1.000 72.86236  ? 86  VAL A CG2 1 
ATOM   654  N  N   . GLU A 1 88  ? 9.43413   16.31001  37.29840  1.000 82.43475  ? 87  GLU A N   1 
ATOM   655  C  CA  . GLU A 1 88  ? 8.06193   16.03876  37.71144  1.000 84.32722  ? 87  GLU A CA  1 
ATOM   656  C  C   . GLU A 1 88  ? 7.05048   16.70846  36.78034  1.000 86.27287  ? 87  GLU A C   1 
ATOM   657  O  O   . GLU A 1 88  ? 6.10238   16.06288  36.30630  1.000 94.33924  ? 87  GLU A O   1 
ATOM   658  C  CB  . GLU A 1 88  ? 7.86690   16.49667  39.15869  1.000 88.07609  ? 87  GLU A CB  1 
ATOM   659  C  CG  . GLU A 1 88  ? 8.60161   15.65378  40.20648  1.000 85.41114  ? 87  GLU A CG  1 
ATOM   660  C  CD  . GLU A 1 88  ? 10.09409  15.95506  40.30672  1.000 87.04600  ? 87  GLU A CD  1 
ATOM   661  O  OE1 . GLU A 1 88  ? 10.56226  16.94554  39.69990  1.000 85.62480  ? 87  GLU A OE1 1 
ATOM   662  O  OE2 . GLU A 1 88  ? 10.80021  15.19727  41.00695  1.000 89.61575  ? 87  GLU A OE2 1 
ATOM   663  N  N   . GLN A 1 89  ? 7.24562   17.99409  36.47822  1.000 82.44209  ? 88  GLN A N   1 
ATOM   664  C  CA  . GLN A 1 89  ? 6.27749   18.68688  35.63311  1.000 83.20552  ? 88  GLN A CA  1 
ATOM   665  C  C   . GLN A 1 89  ? 6.33377   18.18783  34.19377  1.000 85.76049  ? 88  GLN A C   1 
ATOM   666  O  O   . GLN A 1 89  ? 5.30590   18.15396  33.51065  1.000 88.28530  ? 88  GLN A O   1 
ATOM   667  C  CB  . GLN A 1 89  ? 6.48893   20.19999  35.69797  1.000 83.02490  ? 88  GLN A CB  1 
ATOM   668  C  CG  . GLN A 1 89  ? 7.92070   20.65966  35.49159  1.000 83.35531  ? 88  GLN A CG  1 
ATOM   669  C  CD  . GLN A 1 89  ? 8.19513   21.99907  36.14525  1.000 80.90751  ? 88  GLN A CD  1 
ATOM   670  O  OE1 . GLN A 1 89  ? 8.94150   22.08328  37.12147  1.000 77.43323  ? 88  GLN A OE1 1 
ATOM   671  N  NE2 . GLN A 1 89  ? 7.59632   23.05662  35.60646  1.000 79.19064  ? 88  GLN A NE2 1 
ATOM   672  N  N   . VAL A 1 90  ? 7.51977   17.80002  33.71273  1.000 83.92935  ? 89  VAL A N   1 
ATOM   673  C  CA  . VAL A 1 90  ? 7.61868   17.18724  32.38883  1.000 86.26991  ? 89  VAL A CA  1 
ATOM   674  C  C   . VAL A 1 90  ? 6.86344   15.86850  32.36387  1.000 86.55405  ? 89  VAL A C   1 
ATOM   675  O  O   . VAL A 1 90  ? 6.14204   15.56721  31.40659  1.000 86.28693  ? 89  VAL A O   1 
ATOM   676  C  CB  . VAL A 1 90  ? 9.09193   17.00106  31.97792  1.000 79.36944  ? 89  VAL A CB  1 
ATOM   677  C  CG1 . VAL A 1 90  ? 9.19822   16.05140  30.79910  1.000 77.22998  ? 89  VAL A CG1 1 
ATOM   678  C  CG2 . VAL A 1 90  ? 9.70941   18.32899  31.60849  1.000 74.57661  ? 89  VAL A CG2 1 
ATOM   679  N  N   . ALA A 1 91  ? 7.01512   15.06116  33.41563  1.000 87.00991  ? 90  ALA A N   1 
ATOM   680  C  CA  . ALA A 1 91  ? 6.20548   13.85670  33.54196  1.000 88.27386  ? 90  ALA A CA  1 
ATOM   681  C  C   . ALA A 1 91  ? 4.72015   14.18442  33.49976  1.000 90.58390  ? 90  ALA A C   1 
ATOM   682  O  O   . ALA A 1 91  ? 3.91935   13.37756  33.01182  1.000 89.10305  ? 90  ALA A O   1 
ATOM   683  C  CB  . ALA A 1 91  ? 6.55552   13.12563  34.83918  1.000 81.55997  ? 90  ALA A CB  1 
ATOM   684  N  N   . GLU A 1 92  ? 4.33558   15.35765  34.01182  1.000 93.13352  ? 91  GLU A N   1 
ATOM   685  C  CA  . GLU A 1 92  ? 2.93563   15.76995  33.91820  1.000 93.12549  ? 91  GLU A CA  1 
ATOM   686  C  C   . GLU A 1 92  ? 2.55419   16.14655  32.48810  1.000 87.68151  ? 91  GLU A C   1 
ATOM   687  O  O   . GLU A 1 92  ? 1.45608   15.80923  32.02466  1.000 87.96948  ? 91  GLU A O   1 
ATOM   688  C  CB  . GLU A 1 92  ? 2.65569   16.92737  34.87342  1.000 92.74055  ? 91  GLU A CB  1 
ATOM   689  C  CG  . GLU A 1 92  ? 2.94438   16.60121  36.32591  1.000 96.94533  ? 91  GLU A CG  1 
ATOM   690  C  CD  . GLU A 1 92  ? 2.62738   15.15816  36.67726  1.000 105.17369 ? 91  GLU A CD  1 
ATOM   691  O  OE1 . GLU A 1 92  ? 1.45828   14.74764  36.51687  1.000 105.77271 ? 91  GLU A OE1 1 
ATOM   692  O  OE2 . GLU A 1 92  ? 3.54821   14.43171  37.10922  1.000 109.34698 ? 91  GLU A OE2 1 
ATOM   693  N  N   . ILE A 1 93  ? 3.44051   16.84960  31.77409  1.000 84.94501  ? 92  ILE A N   1 
ATOM   694  C  CA  . ILE A 1 93  ? 3.16636   17.15996  30.37231  1.000 85.64639  ? 92  ILE A CA  1 
ATOM   695  C  C   . ILE A 1 93  ? 3.08577   15.87637  29.55961  1.000 87.47431  ? 92  ILE A C   1 
ATOM   696  O  O   . ILE A 1 93  ? 2.25598   15.75505  28.64945  1.000 88.63195  ? 92  ILE A O   1 
ATOM   697  C  CB  . ILE A 1 93  ? 4.22733   18.11318  29.78510  1.000 83.95900  ? 92  ILE A CB  1 
ATOM   698  C  CG1 . ILE A 1 93  ? 4.56569   19.24743  30.75403  1.000 80.49026  ? 92  ILE A CG1 1 
ATOM   699  C  CG2 . ILE A 1 93  ? 3.73552   18.69390  28.46720  1.000 81.89918  ? 92  ILE A CG2 1 
ATOM   700  C  CD1 . ILE A 1 93  ? 5.90736   19.88947  30.47195  1.000 81.98417  ? 92  ILE A CD1 1 
ATOM   701  N  N   . LEU A 1 94  ? 3.92449   14.89252  29.88524  1.000 85.93541  ? 93  LEU A N   1 
ATOM   702  C  CA  . LEU A 1 94  ? 3.88590   13.59117  29.23259  1.000 91.01451  ? 93  LEU A CA  1 
ATOM   703  C  C   . LEU A 1 94  ? 2.67826   12.77049  29.64983  1.000 91.88856  ? 93  LEU A C   1 
ATOM   704  O  O   . LEU A 1 94  ? 2.50203   11.65664  29.14170  1.000 93.49732  ? 93  LEU A O   1 
ATOM   705  C  CB  . LEU A 1 94  ? 5.16071   12.80183  29.54115  1.000 86.83641  ? 93  LEU A CB  1 
ATOM   706  C  CG  . LEU A 1 94  ? 6.47262   13.47054  29.13308  1.000 86.10525  ? 93  LEU A CG  1 
ATOM   707  C  CD1 . LEU A 1 94  ? 7.63974   12.50157  29.19839  1.000 76.50829  ? 93  LEU A CD1 1 
ATOM   708  C  CD2 . LEU A 1 94  ? 6.33565   14.04190  27.75574  1.000 83.24642  ? 93  LEU A CD2 1 
ATOM   709  N  N   . GLN A 1 95  ? 1.85163   13.29843  30.55619  1.000 92.12531  ? 94  GLN A N   1 
ATOM   710  C  CA  . GLN A 1 95  ? 0.70651   12.58452  31.10535  1.000 92.37788  ? 94  GLN A CA  1 
ATOM   711  C  C   . GLN A 1 95  ? 1.11582   11.18161  31.52977  1.000 93.49749  ? 94  GLN A C   1 
ATOM   712  O  O   . GLN A 1 95  ? 0.33694   10.23458  31.39167  1.000 96.27089  ? 94  GLN A O   1 
ATOM   713  C  CB  . GLN A 1 95  ? -0.43972  12.54006  30.09183  1.000 92.61823  ? 94  GLN A CB  1 
ATOM   714  C  CG  . GLN A 1 95  ? -1.08234  13.89607  29.83089  1.000 89.36239  ? 94  GLN A CG  1 
ATOM   715  C  CD  . GLN A 1 95  ? -2.22404  13.82281  28.84015  1.000 95.64035  ? 94  GLN A CD  1 
ATOM   716  O  OE1 . GLN A 1 95  ? -3.39538  13.91205  29.21295  1.000 96.66039  ? 94  GLN A OE1 1 
ATOM   717  N  NE2 . GLN A 1 95  ? -1.88828  13.66121  27.56680  1.000 94.69968  ? 94  GLN A NE2 1 
ATOM   718  N  N   . LEU A 1 96  ? 2.33955   11.04580  32.05105  1.000 91.19070  ? 95  LEU A N   1 
ATOM   719  C  CA  . LEU A 1 96  ? 2.87167   9.73590   32.40612  1.000 88.72034  ? 95  LEU A CA  1 
ATOM   720  C  C   . LEU A 1 96  ? 2.03231   9.04707   33.47253  1.000 91.52307  ? 95  LEU A C   1 
ATOM   721  O  O   . LEU A 1 96  ? 2.10928   7.82122   33.61229  1.000 90.22081  ? 95  LEU A O   1 
ATOM   722  C  CB  . LEU A 1 96  ? 4.32200   9.87841   32.87187  1.000 83.70288  ? 95  LEU A CB  1 
ATOM   723  C  CG  . LEU A 1 96  ? 5.12869   8.59783   33.08814  1.000 84.20863  ? 95  LEU A CG  1 
ATOM   724  C  CD1 . LEU A 1 96  ? 5.37847   7.87532   31.77113  1.000 87.97375  ? 95  LEU A CD1 1 
ATOM   725  C  CD2 . LEU A 1 96  ? 6.43667   8.90273   33.79748  1.000 79.89569  ? 95  LEU A CD2 1 
ATOM   726  N  N   . ASN A 1 97  ? 1.20947   9.80151   34.20517  1.000 96.09481  ? 96  ASN A N   1 
ATOM   727  C  CA  . ASN A 1 97  ? 0.29175   9.18890   35.15555  1.000 100.11673 ? 96  ASN A CA  1 
ATOM   728  C  C   . ASN A 1 97  ? -0.76851  8.34013   34.46562  1.000 102.41066 ? 96  ASN A C   1 
ATOM   729  O  O   . ASN A 1 97  ? -1.45406  7.56368   35.13758  1.000 102.67387 ? 96  ASN A O   1 
ATOM   730  C  CB  . ASN A 1 97  ? -0.38275  10.26316  36.01598  1.000 101.80073 ? 96  ASN A CB  1 
ATOM   731  C  CG  . ASN A 1 97  ? -1.33823  11.13678  35.22449  1.000 105.54703 ? 96  ASN A CG  1 
ATOM   732  O  OD1 . ASN A 1 97  ? -2.47900  10.75186  34.95940  1.000 113.74150 ? 96  ASN A OD1 1 
ATOM   733  N  ND2 . ASN A 1 97  ? -0.88236  12.33062  34.86138  1.000 101.81235 ? 96  ASN A ND2 1 
ATOM   734  N  N   . GLN A 1 98  ? -0.93024  8.47352   33.14974  1.000 102.21025 ? 97  GLN A N   1 
ATOM   735  C  CA  . GLN A 1 98  ? -1.90979  7.67536   32.42513  1.000 101.48742 ? 97  GLN A CA  1 
ATOM   736  C  C   . GLN A 1 98  ? -1.33144  6.40026   31.82850  1.000 98.22412  ? 97  GLN A C   1 
ATOM   737  O  O   . GLN A 1 98  ? -2.09846  5.57471   31.32103  1.000 100.33061 ? 97  GLN A O   1 
ATOM   738  C  CB  . GLN A 1 98  ? -2.55507  8.49760   31.30554  1.000 98.39193  ? 97  GLN A CB  1 
ATOM   739  C  CG  . GLN A 1 98  ? -3.88144  9.12708   31.68657  1.000 102.86190 ? 97  GLN A CG  1 
ATOM   740  C  CD  . GLN A 1 98  ? -3.72569  10.54736  32.17712  1.000 108.66374 ? 97  GLN A CD  1 
ATOM   741  O  OE1 . GLN A 1 98  ? -2.62029  11.08759  32.19917  1.000 113.90170 ? 97  GLN A OE1 1 
ATOM   742  N  NE2 . GLN A 1 98  ? -4.83499  11.16664  32.56606  1.000 107.00890 ? 97  GLN A NE2 1 
ATOM   743  N  N   . GLU A 1 99  ? -0.01310  6.21933   31.86885  1.000 94.41840  ? 98  GLU A N   1 
ATOM   744  C  CA  . GLU A 1 99  ? 0.61493   5.03716   31.30152  1.000 89.19855  ? 98  GLU A CA  1 
ATOM   745  C  C   . GLU A 1 99  ? 0.66768   3.91946   32.34285  1.000 93.47692  ? 98  GLU A C   1 
ATOM   746  O  O   . GLU A 1 99  ? 0.29146   4.09638   33.50332  1.000 97.55958  ? 98  GLU A O   1 
ATOM   747  C  CB  . GLU A 1 99  ? 2.01655   5.36369   30.78088  1.000 89.14162  ? 98  GLU A CB  1 
ATOM   748  C  CG  . GLU A 1 99  ? 2.08645   6.46046   29.71530  1.000 84.69595  ? 98  GLU A CG  1 
ATOM   749  C  CD  . GLU A 1 99  ? 1.72974   5.97667   28.31662  1.000 88.60463  ? 98  GLU A CD  1 
ATOM   750  O  OE1 . GLU A 1 99  ? 1.50242   4.75976   28.13560  1.000 92.11806  ? 98  GLU A OE1 1 
ATOM   751  O  OE2 . GLU A 1 99  ? 1.68305   6.81914   27.39332  1.000 81.93662  ? 98  GLU A OE2 1 
ATOM   752  N  N   . SER A 1 100 ? 1.14365   2.74761   31.91860  1.000 96.21400  ? 99  SER A N   1 
ATOM   753  C  CA  . SER A 1 100 ? 1.27535   1.59646   32.79887  1.000 92.84450  ? 99  SER A CA  1 
ATOM   754  C  C   . SER A 1 100 ? 2.45924   1.80426   33.74542  1.000 96.71219  ? 99  SER A C   1 
ATOM   755  O  O   . SER A 1 100 ? 3.29290   2.68575   33.52527  1.000 98.66576  ? 99  SER A O   1 
ATOM   756  C  CB  . SER A 1 100 ? 1.43812   0.32032   31.97118  1.000 96.39181  ? 99  SER A CB  1 
ATOM   757  O  OG  . SER A 1 100 ? 2.79707   -0.06654  31.87333  1.000 97.57636  ? 99  SER A OG  1 
ATOM   758  N  N   . PRO A 1 101 ? 2.54197   1.02786   34.83540  1.000 102.07587 ? 100 PRO A N   1 
ATOM   759  C  CA  . PRO A 1 101 ? 3.63740   1.25657   35.80125  1.000 100.47150 ? 100 PRO A CA  1 
ATOM   760  C  C   . PRO A 1 101 ? 5.03214   1.11300   35.21224  1.000 98.35788  ? 100 PRO A C   1 
ATOM   761  O  O   . PRO A 1 101 ? 5.88887   1.97533   35.45294  1.000 98.70492  ? 100 PRO A O   1 
ATOM   762  C  CB  . PRO A 1 101 ? 3.36737   0.20268   36.88431  1.000 97.68760  ? 100 PRO A CB  1 
ATOM   763  C  CG  . PRO A 1 101 ? 1.91336   -0.06561  36.79041  1.000 100.57095 ? 100 PRO A CG  1 
ATOM   764  C  CD  . PRO A 1 101 ? 1.57333   0.03641   35.33672  1.000 104.88777 ? 100 PRO A CD  1 
ATOM   765  N  N   . GLU A 1 102 ? 5.29556   0.03870   34.46155  1.000 97.22766  ? 101 GLU A N   1 
ATOM   766  C  CA  . GLU A 1 102 ? 6.64335   -0.17383  33.93866  1.000 96.44454  ? 101 GLU A CA  1 
ATOM   767  C  C   . GLU A 1 102 ? 7.04885   0.94346   32.98526  1.000 91.26559  ? 101 GLU A C   1 
ATOM   768  O  O   . GLU A 1 102 ? 8.20651   1.39005   32.99248  1.000 89.38998  ? 101 GLU A O   1 
ATOM   769  C  CB  . GLU A 1 102 ? 6.73700   -1.53760  33.25562  1.000 96.40598  ? 101 GLU A CB  1 
ATOM   770  C  CG  . GLU A 1 102 ? 6.97447   -2.68238  34.22922  1.000 97.78961  ? 101 GLU A CG  1 
ATOM   771  C  CD  . GLU A 1 102 ? 8.28721   -2.53876  34.98224  1.000 105.25694 ? 101 GLU A CD  1 
ATOM   772  O  OE1 . GLU A 1 102 ? 9.35270   -2.56008  34.33212  1.000 104.02190 ? 101 GLU A OE1 1 
ATOM   773  O  OE2 . GLU A 1 102 ? 8.25726   -2.39234  36.22343  1.000 112.01024 ? 101 GLU A OE2 1 
ATOM   774  N  N   . ILE A 1 103 ? 6.10617   1.41296   32.16355  1.000 92.71396  ? 102 ILE A N   1 
ATOM   775  C  CA  . ILE A 1 103 ? 6.36447   2.58152   31.32842  1.000 89.96915  ? 102 ILE A CA  1 
ATOM   776  C  C   . ILE A 1 103 ? 6.78929   3.75488   32.19645  1.000 88.55585  ? 102 ILE A C   1 
ATOM   777  O  O   . ILE A 1 103 ? 7.77697   4.43821   31.90643  1.000 85.05898  ? 102 ILE A O   1 
ATOM   778  C  CB  . ILE A 1 103 ? 5.12475   2.93672   30.48791  1.000 87.07286  ? 102 ILE A CB  1 
ATOM   779  C  CG1 . ILE A 1 103 ? 4.64982   1.73540   29.67033  1.000 89.68168  ? 102 ILE A CG1 1 
ATOM   780  C  CG2 . ILE A 1 103 ? 5.42590   4.13005   29.58246  1.000 80.78939  ? 102 ILE A CG2 1 
ATOM   781  C  CD1 . ILE A 1 103 ? 3.45644   2.04026   28.79179  1.000 88.20372  ? 102 ILE A CD1 1 
ATOM   782  N  N   . GLN A 1 104 ? 6.04759   3.99995   33.27930  1.000 92.48857  ? 103 GLN A N   1 
ATOM   783  C  CA  . GLN A 1 104 ? 6.36850   5.11324   34.16476  1.000 88.31479  ? 103 GLN A CA  1 
ATOM   784  C  C   . GLN A 1 104 ? 7.77730   4.98375   34.72601  1.000 83.80213  ? 103 GLN A C   1 
ATOM   785  O  O   . GLN A 1 104 ? 8.53915   5.95487   34.74234  1.000 87.28263  ? 103 GLN A O   1 
ATOM   786  C  CB  . GLN A 1 104 ? 5.34983   5.19429   35.29896  1.000 86.84382  ? 103 GLN A CB  1 
ATOM   787  C  CG  . GLN A 1 104 ? 3.94739   5.54016   34.84868  1.000 91.12383  ? 103 GLN A CG  1 
ATOM   788  C  CD  . GLN A 1 104 ? 3.01544   5.80271   36.01144  1.000 92.74301  ? 103 GLN A CD  1 
ATOM   789  O  OE1 . GLN A 1 104 ? 3.40434   5.69044   37.17399  1.000 85.25679  ? 103 GLN A OE1 1 
ATOM   790  N  NE2 . GLN A 1 104 ? 1.77587   6.15942   35.70323  1.000 92.90213  ? 103 GLN A NE2 1 
ATOM   791  N  N   . ALA A 1 105 ? 8.14318   3.78718   35.19003  1.000 80.72726  ? 104 ALA A N   1 
ATOM   792  C  CA  . ALA A 1 105 ? 9.45612   3.61119   35.80466  1.000 82.57432  ? 104 ALA A CA  1 
ATOM   793  C  C   . ALA A 1 105 ? 10.57181  3.85665   34.79464  1.000 83.47896  ? 104 ALA A C   1 
ATOM   794  O  O   . ALA A 1 105 ? 11.51849  4.61369   35.06146  1.000 82.35194  ? 104 ALA A O   1 
ATOM   795  C  CB  . ALA A 1 105 ? 9.57314   2.21148   36.40689  1.000 82.32681  ? 104 ALA A CB  1 
ATOM   796  N  N   . ARG A 1 106 ? 10.47175  3.22564   33.61939  1.000 90.23754  ? 105 ARG A N   1 
ATOM   797  C  CA  . ARG A 1 106 ? 11.49198  3.41708   32.59131  1.000 81.54576  ? 105 ARG A CA  1 
ATOM   798  C  C   . ARG A 1 106 ? 11.58987  4.88222   32.18371  1.000 74.48284  ? 105 ARG A C   1 
ATOM   799  O  O   . ARG A 1 106 ? 12.69338  5.44628   32.07845  1.000 73.36155  ? 105 ARG A O   1 
ATOM   800  C  CB  . ARG A 1 106 ? 11.17044  2.55154   31.37342  1.000 79.72451  ? 105 ARG A CB  1 
ATOM   801  C  CG  . ARG A 1 106 ? 11.08839  1.05621   31.64815  1.000 80.78666  ? 105 ARG A CG  1 
ATOM   802  C  CD  . ARG A 1 106 ? 12.45495  0.41383   31.54490  1.000 84.93173  ? 105 ARG A CD  1 
ATOM   803  N  NE  . ARG A 1 106 ? 13.03262  0.60748   30.22115  1.000 83.23396  ? 105 ARG A NE  1 
ATOM   804  C  CZ  . ARG A 1 106 ? 13.01646  -0.30340  29.25793  1.000 80.28891  ? 105 ARG A CZ  1 
ATOM   805  N  NH1 . ARG A 1 106 ? 12.45534  -1.48859  29.43554  1.000 83.20061  ? 105 ARG A NH1 1 
ATOM   806  N  NH2 . ARG A 1 106 ? 13.58990  -0.02407  28.09163  1.000 84.77046  ? 105 ARG A NH2 1 
ATOM   807  N  N   . VAL A 1 107 ? 10.43913  5.52359   31.97401  1.000 71.54766  ? 106 VAL A N   1 
ATOM   808  C  CA  . VAL A 1 107 ? 10.43599  6.91643   31.55283  1.000 73.86031  ? 106 VAL A CA  1 
ATOM   809  C  C   . VAL A 1 107 ? 11.08227  7.78769   32.61364  1.000 74.31655  ? 106 VAL A C   1 
ATOM   810  O  O   . VAL A 1 107 ? 11.91605  8.63427   32.29864  1.000 70.22513  ? 106 VAL A O   1 
ATOM   811  C  CB  . VAL A 1 107 ? 9.00811   7.39250   31.23642  1.000 76.74877  ? 106 VAL A CB  1 
ATOM   812  C  CG1 . VAL A 1 107 ? 8.98722   8.90939   31.10590  1.000 71.43525  ? 106 VAL A CG1 1 
ATOM   813  C  CG2 . VAL A 1 107 ? 8.50613   6.75660   29.95683  1.000 75.80221  ? 106 VAL A CG2 1 
ATOM   814  N  N   . LEU A 1 108 ? 10.69634  7.60582   33.87981  1.000 77.33567  ? 107 LEU A N   1 
ATOM   815  C  CA  . LEU A 1 108 ? 11.25781  8.42284   34.94995  1.000 73.33293  ? 107 LEU A CA  1 
ATOM   816  C  C   . LEU A 1 108 ? 12.76828  8.25258   35.03051  1.000 71.52448  ? 107 LEU A C   1 
ATOM   817  O  O   . LEU A 1 108 ? 13.49689  9.23011   35.24177  1.000 68.50570  ? 107 LEU A O   1 
ATOM   818  C  CB  . LEU A 1 108 ? 10.59638  8.07141   36.28340  1.000 71.22947  ? 107 LEU A CB  1 
ATOM   819  C  CG  . LEU A 1 108 ? 9.12962   8.49935   36.42218  1.000 69.29444  ? 107 LEU A CG  1 
ATOM   820  C  CD1 . LEU A 1 108 ? 8.44534   7.76091   37.56389  1.000 64.63722  ? 107 LEU A CD1 1 
ATOM   821  C  CD2 . LEU A 1 108 ? 8.99668   10.00849  36.60275  1.000 68.98100  ? 107 LEU A CD2 1 
ATOM   822  N  N   . VAL A 1 109 ? 13.25994  7.02243   34.83711  1.000 68.76034  ? 108 VAL A N   1 
ATOM   823  C  CA  . VAL A 1 109 ? 14.70616  6.81088   34.75799  1.000 67.58391  ? 108 VAL A CA  1 
ATOM   824  C  C   . VAL A 1 109 ? 15.30416  7.70288   33.67809  1.000 70.18012  ? 108 VAL A C   1 
ATOM   825  O  O   . VAL A 1 109 ? 16.29770  8.40182   33.90020  1.000 68.21034  ? 108 VAL A O   1 
ATOM   826  C  CB  . VAL A 1 109 ? 15.02752  5.32657   34.49906  1.000 69.92725  ? 108 VAL A CB  1 
ATOM   827  C  CG1 . VAL A 1 109 ? 16.50817  5.15391   34.16411  1.000 66.20833  ? 108 VAL A CG1 1 
ATOM   828  C  CG2 . VAL A 1 109 ? 14.65975  4.48151   35.70821  1.000 72.44288  ? 108 VAL A CG2 1 
ATOM   829  N  N   . ILE A 1 110 ? 14.67980  7.71531   32.49959  1.000 69.85540  ? 109 ILE A N   1 
ATOM   830  C  CA  . ILE A 1 110 ? 15.23058  8.46696   31.36918  1.000 69.57084  ? 109 ILE A CA  1 
ATOM   831  C  C   . ILE A 1 110 ? 15.12235  9.97782   31.59342  1.000 65.89105  ? 109 ILE A C   1 
ATOM   832  O  O   . ILE A 1 110 ? 16.04056  10.74189  31.25944  1.000 67.98948  ? 109 ILE A O   1 
ATOM   833  C  CB  . ILE A 1 110 ? 14.52698  8.02244   30.07607  1.000 71.15159  ? 109 ILE A CB  1 
ATOM   834  C  CG1 . ILE A 1 110 ? 14.82878  6.54683   29.82401  1.000 74.68648  ? 109 ILE A CG1 1 
ATOM   835  C  CG2 . ILE A 1 110 ? 14.95062  8.88273   28.90256  1.000 62.97067  ? 109 ILE A CG2 1 
ATOM   836  C  CD1 . ILE A 1 110 ? 13.83506  5.85027   28.93237  1.000 73.38672  ? 109 ILE A CD1 1 
ATOM   837  N  N   . LEU A 1 111 ? 13.98913  10.43325  32.12787  1.000 65.81496  ? 110 LEU A N   1 
ATOM   838  C  CA  . LEU A 1 111 ? 13.78699  11.85569  32.37768  1.000 62.68726  ? 110 LEU A CA  1 
ATOM   839  C  C   . LEU A 1 111 ? 14.78611  12.37097  33.40035  1.000 64.90641  ? 110 LEU A C   1 
ATOM   840  O  O   . LEU A 1 111 ? 15.38334  13.43996  33.21767  1.000 67.19989  ? 110 LEU A O   1 
ATOM   841  C  CB  . LEU A 1 111 ? 12.35636  12.11029  32.85187  1.000 62.72165  ? 110 LEU A CB  1 
ATOM   842  C  CG  . LEU A 1 111 ? 11.22474  12.14895  31.82029  1.000 64.55203  ? 110 LEU A CG  1 
ATOM   843  C  CD1 . LEU A 1 111 ? 9.88334   12.39197  32.50088  1.000 72.36040  ? 110 LEU A CD1 1 
ATOM   844  C  CD2 . LEU A 1 111 ? 11.48751  13.21819  30.77174  1.000 72.88213  ? 110 LEU A CD2 1 
ATOM   845  N  N   . ASN A 1 112 ? 14.99591  11.61054  34.47754  1.000 66.80024  ? 111 ASN A N   1 
ATOM   846  C  CA  . ASN A 1 112 ? 16.02628  11.96607  35.44299  1.000 70.33462  ? 111 ASN A CA  1 
ATOM   847  C  C   . ASN A 1 112 ? 17.40513  11.91216  34.81006  1.000 67.65363  ? 111 ASN A C   1 
ATOM   848  O  O   . ASN A 1 112 ? 18.27679  12.71870  35.14154  1.000 67.84178  ? 111 ASN A O   1 
ATOM   849  C  CB  . ASN A 1 112 ? 15.96494  11.03836  36.65415  1.000 70.42415  ? 111 ASN A CB  1 
ATOM   850  C  CG  . ASN A 1 112 ? 14.72134  11.24810  37.48401  1.000 71.03107  ? 111 ASN A CG  1 
ATOM   851  O  OD1 . ASN A 1 112 ? 14.52925  12.31172  38.07221  1.000 74.89281  ? 111 ASN A OD1 1 
ATOM   852  N  ND2 . ASN A 1 112 ? 13.87343  10.22909  37.55003  1.000 66.23293  ? 111 ASN A ND2 1 
ATOM   853  N  N   . ASN A 1 113 ? 17.62834  10.95882  33.90528  1.000 68.55349  ? 112 ASN A N   1 
ATOM   854  C  CA  . ASN A 1 113 ? 18.91581  10.89019  33.23176  1.000 65.03796  ? 112 ASN A CA  1 
ATOM   855  C  C   . ASN A 1 113 ? 19.18491  12.14733  32.41686  1.000 66.50771  ? 112 ASN A C   1 
ATOM   856  O  O   . ASN A 1 113 ? 20.32474  12.62349  32.37393  1.000 64.17337  ? 112 ASN A O   1 
ATOM   857  C  CB  . ASN A 1 113 ? 18.97320  9.64105   32.35423  1.000 64.56747  ? 112 ASN A CB  1 
ATOM   858  C  CG  . ASN A 1 113 ? 19.26224  8.38335   33.15534  1.000 68.90062  ? 112 ASN A CG  1 
ATOM   859  O  OD1 . ASN A 1 113 ? 19.26372  8.40419   34.38667  1.000 74.03552  ? 112 ASN A OD1 1 
ATOM   860  N  ND2 . ASN A 1 113 ? 19.50970  7.28248   32.45981  1.000 72.53118  ? 112 ASN A ND2 1 
ATOM   861  N  N   . TYR A 1 114 ? 18.15830  12.70343  31.77024  1.000 60.73560  ? 113 TYR A N   1 
ATOM   862  C  CA  . TYR A 1 114 ? 18.39148  13.92517  31.00681  1.000 66.08874  ? 113 TYR A CA  1 
ATOM   863  C  C   . TYR A 1 114 ? 18.48032  15.14920  31.91103  1.000 66.27712  ? 113 TYR A C   1 
ATOM   864  O  O   . TYR A 1 114 ? 19.20633  16.09732  31.59245  1.000 63.18248  ? 113 TYR A O   1 
ATOM   865  C  CB  . TYR A 1 114 ? 17.31640  14.12974  29.94015  1.000 61.26492  ? 113 TYR A CB  1 
ATOM   866  C  CG  . TYR A 1 114 ? 17.79720  15.05291  28.84520  1.000 70.37228  ? 113 TYR A CG  1 
ATOM   867  C  CD1 . TYR A 1 114 ? 18.74105  14.62557  27.92114  1.000 61.20530  ? 113 TYR A CD1 1 
ATOM   868  C  CD2 . TYR A 1 114 ? 17.33434  16.35667  28.75107  1.000 61.90095  ? 113 TYR A CD2 1 
ATOM   869  C  CE1 . TYR A 1 114 ? 19.19996  15.46778  26.92341  1.000 56.42559  ? 113 TYR A CE1 1 
ATOM   870  C  CE2 . TYR A 1 114 ? 17.78730  17.20754  27.75469  1.000 58.98126  ? 113 TYR A CE2 1 
ATOM   871  C  CZ  . TYR A 1 114 ? 18.72089  16.75960  26.84347  1.000 57.71773  ? 113 TYR A CZ  1 
ATOM   872  O  OH  . TYR A 1 114 ? 19.17102  17.60675  25.85726  1.000 53.43348  ? 113 TYR A OH  1 
ATOM   873  N  N   . TYR A 1 115 ? 17.76424  15.14571  33.03810  1.000 66.07257  ? 114 TYR A N   1 
ATOM   874  C  CA  . TYR A 1 115 ? 17.89423  16.24154  33.99312  1.000 61.23105  ? 114 TYR A CA  1 
ATOM   875  C  C   . TYR A 1 115 ? 19.28212  16.27098  34.61735  1.000 60.87178  ? 114 TYR A C   1 
ATOM   876  O  O   . TYR A 1 115 ? 19.83273  17.35261  34.86119  1.000 68.96901  ? 114 TYR A O   1 
ATOM   877  C  CB  . TYR A 1 115 ? 16.82354  16.10856  35.07172  1.000 66.93269  ? 114 TYR A CB  1 
ATOM   878  C  CG  . TYR A 1 115 ? 16.79857  17.22212  36.09116  1.000 71.53358  ? 114 TYR A CG  1 
ATOM   879  C  CD1 . TYR A 1 115 ? 16.20137  18.44148  35.80159  1.000 67.61175  ? 114 TYR A CD1 1 
ATOM   880  C  CD2 . TYR A 1 115 ? 17.35189  17.04973  37.34955  1.000 68.21302  ? 114 TYR A CD2 1 
ATOM   881  C  CE1 . TYR A 1 115 ? 16.16862  19.46764  36.73460  1.000 83.60610  ? 114 TYR A CE1 1 
ATOM   882  C  CE2 . TYR A 1 115 ? 17.32338  18.06909  38.28850  1.000 71.54161  ? 114 TYR A CE2 1 
ATOM   883  C  CZ  . TYR A 1 115 ? 16.72914  19.27590  37.97697  1.000 69.44095  ? 114 TYR A CZ  1 
ATOM   884  O  OH  . TYR A 1 115 ? 16.70169  20.28844  38.90814  1.000 70.02891  ? 114 TYR A OH  1 
ATOM   885  N  N   . GLN A 1 116 ? 19.85689  15.09435  34.87984  1.000 62.73315  ? 115 GLN A N   1 
ATOM   886  C  CA  . GLN A 1 116 ? 21.20567  15.02328  35.42318  1.000 67.56623  ? 115 GLN A CA  1 
ATOM   887  C  C   . GLN A 1 116 ? 22.23557  15.49050  34.40796  1.000 66.92721  ? 115 GLN A C   1 
ATOM   888  O  O   . GLN A 1 116 ? 23.24712  16.08836  34.78587  1.000 69.87661  ? 115 GLN A O   1 
ATOM   889  C  CB  . GLN A 1 116 ? 21.52381  13.59552  35.87245  1.000 66.03721  ? 115 GLN A CB  1 
ATOM   890  C  CG  . GLN A 1 116 ? 20.61456  13.05379  36.95851  1.000 72.88702  ? 115 GLN A CG  1 
ATOM   891  C  CD  . GLN A 1 116 ? 20.63132  13.90521  38.20377  1.000 77.57038  ? 115 GLN A CD  1 
ATOM   892  O  OE1 . GLN A 1 116 ? 21.69485  14.20941  38.74302  1.000 82.30257  ? 115 GLN A OE1 1 
ATOM   893  N  NE2 . GLN A 1 116 ? 19.45066  14.29866  38.67067  1.000 77.80793  ? 115 GLN A NE2 1 
ATOM   894  N  N   . GLN A 1 117 ? 21.99842  15.23390  33.12786  1.000 68.81904  ? 116 GLN A N   1 
ATOM   895  C  CA  . GLN A 1 117 ? 22.92073  15.64266  32.06767  1.000 72.01198  ? 116 GLN A CA  1 
ATOM   896  C  C   . GLN A 1 117 ? 22.10689  15.92776  30.81465  1.000 58.21819  ? 116 GLN A C   1 
ATOM   897  O  O   . GLN A 1 117 ? 21.84701  15.02036  30.00502  1.000 61.99675  ? 116 GLN A O   1 
ATOM   898  C  CB  . GLN A 1 117 ? 23.98284  14.57765  31.80409  1.000 70.88270  ? 116 GLN A CB  1 
ATOM   899  C  CG  . GLN A 1 117 ? 25.13763  14.55730  32.81205  1.000 73.19442  ? 116 GLN A CG  1 
ATOM   900  C  CD  . GLN A 1 117 ? 25.90845  13.24554  32.80808  1.000 88.08019  ? 116 GLN A CD  1 
ATOM   901  O  OE1 . GLN A 1 117 ? 25.50125  12.26922  32.17627  1.000 90.24268  ? 116 GLN A OE1 1 
ATOM   902  N  NE2 . GLN A 1 117 ? 27.02701  13.21787  33.52438  1.000 91.90045  ? 116 GLN A NE2 1 
ATOM   903  N  N   . PRO A 1 118 ? 21.67321  17.17786  30.61035  1.000 63.98707  ? 117 PRO A N   1 
ATOM   904  C  CA  . PRO A 1 118 ? 21.01687  17.52647  29.34351  1.000 58.77436  ? 117 PRO A CA  1 
ATOM   905  C  C   . PRO A 1 118 ? 22.03861  17.69117  28.23054  1.000 56.54767  ? 117 PRO A C   1 
ATOM   906  O  O   . PRO A 1 118 ? 22.75273  18.70013  28.18001  1.000 59.46735  ? 117 PRO A O   1 
ATOM   907  C  CB  . PRO A 1 118 ? 20.31074  18.85522  29.65265  1.000 63.35765  ? 117 PRO A CB  1 
ATOM   908  C  CG  . PRO A 1 118 ? 20.43621  19.05328  31.15071  1.000 55.49859  ? 117 PRO A CG  1 
ATOM   909  C  CD  . PRO A 1 118 ? 21.65602  18.29999  31.56543  1.000 55.44365  ? 117 PRO A CD  1 
ATOM   910  N  N   . ILE A 1 119 ? 22.09679  16.71487  27.32054  1.000 58.27738  ? 118 ILE A N   1 
ATOM   911  C  CA  . ILE A 1 119 ? 23.19496  16.65276  26.35877  1.000 58.13022  ? 118 ILE A CA  1 
ATOM   912  C  C   . ILE A 1 119 ? 23.10927  17.77153  25.32630  1.000 56.08765  ? 118 ILE A C   1 
ATOM   913  O  O   . ILE A 1 119 ? 24.13519  18.19876  24.78194  1.000 56.08142  ? 118 ILE A O   1 
ATOM   914  C  CB  . ILE A 1 119 ? 23.23588  15.27268  25.67830  1.000 57.80374  ? 118 ILE A CB  1 
ATOM   915  C  CG1 . ILE A 1 119 ? 21.97988  15.04882  24.83418  1.000 56.22224  ? 118 ILE A CG1 1 
ATOM   916  C  CG2 . ILE A 1 119 ? 23.40622  14.17597  26.71419  1.000 60.58297  ? 118 ILE A CG2 1 
ATOM   917  C  CD1 . ILE A 1 119 ? 22.01160  13.77829  24.02214  1.000 59.31042  ? 118 ILE A CD1 1 
ATOM   918  N  N   . LEU A 1 120 ? 21.90398  18.24663  25.01868  1.000 55.24570  ? 119 LEU A N   1 
ATOM   919  C  CA  . LEU A 1 120 ? 21.70135  19.26574  23.99525  1.000 63.72210  ? 119 LEU A CA  1 
ATOM   920  C  C   . LEU A 1 120 ? 21.69785  20.68886  24.54642  1.000 57.39292  ? 119 LEU A C   1 
ATOM   921  O  O   . LEU A 1 120 ? 21.62545  21.63710  23.75721  1.000 64.75083  ? 119 LEU A O   1 
ATOM   922  C  CB  . LEU A 1 120 ? 20.38636  19.00349  23.24814  1.000 56.94252  ? 119 LEU A CB  1 
ATOM   923  C  CG  . LEU A 1 120 ? 20.27819  17.71243  22.43333  1.000 56.17123  ? 119 LEU A CG  1 
ATOM   924  C  CD1 . LEU A 1 120 ? 18.84035  17.45041  21.99874  1.000 58.37362  ? 119 LEU A CD1 1 
ATOM   925  C  CD2 . LEU A 1 120 ? 21.19554  17.77351  21.22538  1.000 62.43026  ? 119 LEU A CD2 1 
ATOM   926  N  N   . LEU A 1 121 ? 21.77480  20.86447  25.87029  1.000 57.52196  ? 120 LEU A N   1 
ATOM   927  C  CA  . LEU A 1 121 ? 21.79486  22.21127  26.43745  1.000 65.11852  ? 120 LEU A CA  1 
ATOM   928  C  C   . LEU A 1 121 ? 23.04442  22.96923  26.00630  1.000 61.61117  ? 120 LEU A C   1 
ATOM   929  O  O   . LEU A 1 121 ? 22.97725  24.16151  25.68446  1.000 63.76162  ? 120 LEU A O   1 
ATOM   930  C  CB  . LEU A 1 121 ? 21.70233  22.13674  27.96308  1.000 65.19417  ? 120 LEU A CB  1 
ATOM   931  C  CG  . LEU A 1 121 ? 21.07284  23.31952  28.71124  1.000 71.93579  ? 120 LEU A CG  1 
ATOM   932  C  CD1 . LEU A 1 121 ? 20.72104  22.91775  30.13242  1.000 64.13455  ? 120 LEU A CD1 1 
ATOM   933  C  CD2 . LEU A 1 121 ? 21.98176  24.54070  28.71456  1.000 69.40053  ? 120 LEU A CD2 1 
ATOM   934  N  N   . ASN A 1 122 ? 24.18944  22.28945  25.98541  1.000 66.33866  ? 121 ASN A N   1 
ATOM   935  C  CA  . ASN A 1 122 ? 25.44665  22.89211  25.56458  1.000 66.36412  ? 121 ASN A CA  1 
ATOM   936  C  C   . ASN A 1 122 ? 25.50593  23.14920  24.06172  1.000 70.48277  ? 121 ASN A C   1 
ATOM   937  O  O   . ASN A 1 122 ? 26.40934  23.86058  23.60838  1.000 67.25993  ? 121 ASN A O   1 
ATOM   938  C  CB  . ASN A 1 122 ? 26.60121  21.98082  26.00144  1.000 76.40535  ? 121 ASN A CB  1 
ATOM   939  C  CG  . ASN A 1 122 ? 27.96534  22.55539  25.68438  1.000 81.05312  ? 121 ASN A CG  1 
ATOM   940  O  OD1 . ASN A 1 122 ? 28.42637  23.48940  26.34016  1.000 76.20941  ? 121 ASN A OD1 1 
ATOM   941  N  ND2 . ASN A 1 122 ? 28.62761  21.98625  24.68504  1.000 82.55019  ? 121 ASN A ND2 1 
ATOM   942  N  N   . LYS A 1 123 ? 24.56101  22.62021  23.28630  1.000 69.16133  ? 122 LYS A N   1 
ATOM   943  C  CA  . LYS A 1 123 ? 24.63507  22.63545  21.83227  1.000 62.10921  ? 122 LYS A CA  1 
ATOM   944  C  C   . LYS A 1 123 ? 23.68846  23.67368  21.23718  1.000 67.42308  ? 122 LYS A C   1 
ATOM   945  O  O   . LYS A 1 123 ? 22.65964  24.01599  21.82715  1.000 69.80009  ? 122 LYS A O   1 
ATOM   946  C  CB  . LYS A 1 123 ? 24.30152  21.25803  21.25562  1.000 64.68204  ? 122 LYS A CB  1 
ATOM   947  C  CG  . LYS A 1 123 ? 24.84819  20.09050  22.05210  1.000 66.06359  ? 122 LYS A CG  1 
ATOM   948  C  CD  . LYS A 1 123 ? 26.32444  19.86236  21.77594  1.000 65.08751  ? 122 LYS A CD  1 
ATOM   949  C  CE  . LYS A 1 123 ? 26.81253  18.59851  22.46812  1.000 63.32481  ? 122 LYS A CE  1 
ATOM   950  N  NZ  . LYS A 1 123 ? 26.56318  18.65111  23.93631  1.000 60.01739  ? 122 LYS A NZ  1 
ATOM   951  N  N   . GLU A 1 124 ? 24.05595  24.17762  20.05787  1.000 63.10099  ? 123 GLU A N   1 
ATOM   952  C  CA  . GLU A 1 124 ? 23.21846  25.10334  19.29280  1.000 63.41151  ? 123 GLU A CA  1 
ATOM   953  C  C   . GLU A 1 124 ? 22.21813  24.27752  18.49379  1.000 63.17484  ? 123 GLU A C   1 
ATOM   954  O  O   . GLU A 1 124 ? 22.54900  23.72747  17.44193  1.000 60.80347  ? 123 GLU A O   1 
ATOM   955  C  CB  . GLU A 1 124 ? 24.07527  25.97804  18.38224  1.000 63.62996  ? 123 GLU A CB  1 
ATOM   956  C  CG  . GLU A 1 124 ? 23.29143  26.83434  17.40446  1.000 66.34473  ? 123 GLU A CG  1 
ATOM   957  C  CD  . GLU A 1 124 ? 24.18757  27.49202  16.37431  1.000 69.74159  ? 123 GLU A CD  1 
ATOM   958  O  OE1 . GLU A 1 124 ? 25.41602  27.54005  16.59237  1.000 68.70938  ? 123 GLU A OE1 1 
ATOM   959  O  OE2 . GLU A 1 124 ? 23.67034  27.95590  15.34019  1.000 68.15766  ? 123 GLU A OE2 1 
ATOM   960  N  N   . ILE A 1 125 ? 20.98808  24.18968  18.99125  1.000 64.87079  ? 124 ILE A N   1 
ATOM   961  C  CA  . ILE A 1 125 ? 19.99008  23.28779  18.42492  1.000 59.25120  ? 124 ILE A CA  1 
ATOM   962  C  C   . ILE A 1 125 ? 19.37752  23.92485  17.18154  1.000 60.24973  ? 124 ILE A C   1 
ATOM   963  O  O   . ILE A 1 125 ? 18.81293  25.02221  17.24516  1.000 75.08501  ? 124 ILE A O   1 
ATOM   964  C  CB  . ILE A 1 125 ? 18.91042  22.95151  19.46269  1.000 59.59260  ? 124 ILE A CB  1 
ATOM   965  C  CG1 . ILE A 1 125 ? 19.55192  22.40355  20.74134  1.000 52.17767  ? 124 ILE A CG1 1 
ATOM   966  C  CG2 . ILE A 1 125 ? 17.91426  21.96321  18.89657  1.000 60.66822  ? 124 ILE A CG2 1 
ATOM   967  C  CD1 . ILE A 1 125 ? 18.55026  22.02760  21.81514  1.000 51.27319  ? 124 ILE A CD1 1 
ATOM   968  N  N   . ILE A 1 126 ? 19.49070  23.23548  16.04416  1.000 63.25835  ? 125 ILE A N   1 
ATOM   969  C  CA  . ILE A 1 126 ? 18.82647  23.69062  14.82674  1.000 62.01732  ? 125 ILE A CA  1 
ATOM   970  C  C   . ILE A 1 126 ? 17.36660  23.25417  14.82287  1.000 60.86608  ? 125 ILE A C   1 
ATOM   971  O  O   . ILE A 1 126 ? 16.47275  24.03973  14.48717  1.000 60.36695  ? 125 ILE A O   1 
ATOM   972  C  CB  . ILE A 1 126 ? 19.58024  23.17579  13.58589  1.000 59.67448  ? 125 ILE A CB  1 
ATOM   973  C  CG1 . ILE A 1 126 ? 21.03750  23.64496  13.60744  1.000 58.36501  ? 125 ILE A CG1 1 
ATOM   974  C  CG2 . ILE A 1 126 ? 18.88611  23.62042  12.30403  1.000 63.10310  ? 125 ILE A CG2 1 
ATOM   975  C  CD1 . ILE A 1 126 ? 21.80428  23.30236  12.35015  1.000 60.29102  ? 125 ILE A CD1 1 
ATOM   976  N  N   . ASN A 1 127 ? 17.09966  22.00590  15.20682  1.000 59.39488  ? 126 ASN A N   1 
ATOM   977  C  CA  . ASN A 1 127 ? 15.72659  21.53772  15.34730  1.000 58.04699  ? 126 ASN A CA  1 
ATOM   978  C  C   . ASN A 1 127 ? 15.67380  20.38297  16.33797  1.000 62.19301  ? 126 ASN A C   1 
ATOM   979  O  O   . ASN A 1 127 ? 16.53169  19.49833  16.31415  1.000 62.71313  ? 126 ASN A O   1 
ATOM   980  C  CB  . ASN A 1 127 ? 15.13263  21.09419  14.00525  1.000 60.40555  ? 126 ASN A CB  1 
ATOM   981  C  CG  . ASN A 1 127 ? 13.71077  20.57694  14.14531  1.000 58.44106  ? 126 ASN A CG  1 
ATOM   982  O  OD1 . ASN A 1 127 ? 12.82288  21.29037  14.61321  1.000 63.36601  ? 126 ASN A OD1 1 
ATOM   983  N  ND2 . ASN A 1 127 ? 13.48918  19.32894  13.74079  1.000 64.72080  ? 126 ASN A ND2 1 
ATOM   984  N  N   . LEU A 1 128 ? 14.65739  20.39733  17.20019  1.000 57.31616  ? 127 LEU A N   1 
ATOM   985  C  CA  . LEU A 1 128 ? 14.38466  19.29810  18.12192  1.000 57.87798  ? 127 LEU A CA  1 
ATOM   986  C  C   . LEU A 1 128 ? 12.93390  18.88513  17.92901  1.000 59.02672  ? 127 LEU A C   1 
ATOM   987  O  O   . LEU A 1 128 ? 12.02004  19.66611  18.21417  1.000 62.20979  ? 127 LEU A O   1 
ATOM   988  C  CB  . LEU A 1 128 ? 14.65413  19.69471  19.57485  1.000 57.20970  ? 127 LEU A CB  1 
ATOM   989  C  CG  . LEU A 1 128 ? 14.36013  18.58009  20.58037  1.000 59.34268  ? 127 LEU A CG  1 
ATOM   990  C  CD1 . LEU A 1 128 ? 15.22255  17.36424  20.27512  1.000 53.14268  ? 127 LEU A CD1 1 
ATOM   991  C  CD2 . LEU A 1 128 ? 14.57754  19.05249  22.00788  1.000 60.31226  ? 127 LEU A CD2 1 
ATOM   992  N  N   . SER A 1 129 ? 12.72321  17.66654  17.44577  1.000 62.23629  ? 128 SER A N   1 
ATOM   993  C  CA  . SER A 1 129 ? 11.37929  17.21728  17.13046  1.000 64.82822  ? 128 SER A CA  1 
ATOM   994  C  C   . SER A 1 129 ? 10.68254  16.65677  18.36448  1.000 67.77762  ? 128 SER A C   1 
ATOM   995  O  O   . SER A 1 129 ? 11.30990  16.18545  19.31613  1.000 61.79222  ? 128 SER A O   1 
ATOM   996  C  CB  . SER A 1 129 ? 11.40148  16.17273  16.01060  1.000 62.80606  ? 128 SER A CB  1 
ATOM   997  O  OG  . SER A 1 129 ? 12.36770  15.16446  16.25492  1.000 60.80652  ? 128 SER A OG  1 
ATOM   998  N  N   . ARG A 1 130 ? 9.35652   16.72510  18.32267  1.000 73.55870  ? 129 ARG A N   1 
ATOM   999  C  CA  . ARG A 1 130 ? 8.45812   16.28440  19.37755  1.000 71.86349  ? 129 ARG A CA  1 
ATOM   1000 C  C   . ARG A 1 130 ? 8.18724   14.78458  19.33489  1.000 78.48383  ? 129 ARG A C   1 
ATOM   1001 O  O   . ARG A 1 130 ? 7.60039   14.24233  20.28032  1.000 77.10072  ? 129 ARG A O   1 
ATOM   1002 C  CB  . ARG A 1 130 ? 7.15413   17.07909  19.24209  1.000 77.39663  ? 129 ARG A CB  1 
ATOM   1003 C  CG  . ARG A 1 130 ? 6.05799   16.84459  20.24512  1.000 80.53747  ? 129 ARG A CG  1 
ATOM   1004 C  CD  . ARG A 1 130 ? 5.05968   17.97917  20.10653  1.000 85.83968  ? 129 ARG A CD  1 
ATOM   1005 N  NE  . ARG A 1 130 ? 3.77717   17.71982  20.74452  1.000 92.26978  ? 129 ARG A NE  1 
ATOM   1006 C  CZ  . ARG A 1 130 ? 2.71728   18.50564  20.61108  1.000 94.20064  ? 129 ARG A CZ  1 
ATOM   1007 N  NH1 . ARG A 1 130 ? 2.75545   19.59789  19.86325  1.000 92.46000  ? 129 ARG A NH1 1 
ATOM   1008 N  NH2 . ARG A 1 130 ? 1.59059   18.18853  21.24048  1.000 94.04959  ? 129 ARG A NH2 1 
ATOM   1009 N  N   . GLY A 1 131 ? 8.61958   14.10573  18.27382  1.000 75.83068  ? 130 GLY A N   1 
ATOM   1010 C  CA  . GLY A 1 131 ? 8.39410   12.68983  18.10162  1.000 76.09203  ? 130 GLY A CA  1 
ATOM   1011 C  C   . GLY A 1 131 ? 7.04933   12.32404  17.51990  1.000 83.60409  ? 130 GLY A C   1 
ATOM   1012 O  O   . GLY A 1 131 ? 6.81292   11.13984  17.24438  1.000 80.73049  ? 130 GLY A O   1 
ATOM   1013 N  N   . ASP A 1 132 ? 6.16442   13.29796  17.30882  1.000 86.73001  ? 131 ASP A N   1 
ATOM   1014 C  CA  . ASP A 1 132 ? 4.82534   13.03359  16.79812  1.000 92.55700  ? 131 ASP A CA  1 
ATOM   1015 C  C   . ASP A 1 132 ? 4.57053   13.72879  15.46443  1.000 91.16228  ? 131 ASP A C   1 
ATOM   1016 O  O   . ASP A 1 132 ? 3.41336   13.96336  15.10484  1.000 97.09498  ? 131 ASP A O   1 
ATOM   1017 C  CB  . ASP A 1 132 ? 3.76925   13.44732  17.82843  1.000 87.68118  ? 131 ASP A CB  1 
ATOM   1018 C  CG  . ASP A 1 132 ? 3.83461   14.92672  18.18551  1.000 92.19197  ? 131 ASP A CG  1 
ATOM   1019 O  OD1 . ASP A 1 132 ? 4.65661   15.66461  17.60086  1.000 94.07887  ? 131 ASP A OD1 1 
ATOM   1020 O  OD2 . ASP A 1 132 ? 3.05330   15.35542  19.06325  1.000 97.88424  ? 131 ASP A OD2 1 
ATOM   1021 N  N   . GLU A 1 133 ? 5.62458   14.06578  14.72072  1.000 88.60524  ? 132 GLU A N   1 
ATOM   1022 C  CA  . GLU A 1 133 ? 5.47617   14.81888  13.48197  1.000 91.39506  ? 132 GLU A CA  1 
ATOM   1023 C  C   . GLU A 1 133 ? 5.41655   13.94309  12.23852  1.000 87.42837  ? 132 GLU A C   1 
ATOM   1024 O  O   . GLU A 1 133 ? 5.10283   14.45287  11.15682  1.000 88.63480  ? 132 GLU A O   1 
ATOM   1025 C  CB  . GLU A 1 133 ? 6.62351   15.82457  13.33156  1.000 88.03364  ? 132 GLU A CB  1 
ATOM   1026 C  CG  . GLU A 1 133 ? 6.64090   16.90631  14.39039  1.000 88.58101  ? 132 GLU A CG  1 
ATOM   1027 C  CD  . GLU A 1 133 ? 7.58963   16.59978  15.52808  1.000 91.97604  ? 132 GLU A CD  1 
ATOM   1028 O  OE1 . GLU A 1 133 ? 7.63607   15.43530  15.97943  1.000 92.72320  ? 132 GLU A OE1 1 
ATOM   1029 O  OE2 . GLU A 1 133 ? 8.29726   17.52946  15.96811  1.000 93.52278  ? 132 GLU A OE2 1 
ATOM   1030 N  N   . GLY A 1 134 ? 5.70013   12.65401  12.36263  1.000 84.77795  ? 133 GLY A N   1 
ATOM   1031 C  CA  . GLY A 1 134 ? 5.70943   11.77006  11.21571  1.000 82.71392  ? 133 GLY A CA  1 
ATOM   1032 C  C   . GLY A 1 134 ? 6.86792   12.05730  10.27101  1.000 79.88675  ? 133 GLY A C   1 
ATOM   1033 O  O   . GLY A 1 134 ? 7.74975   12.87512  10.53374  1.000 80.60873  ? 133 GLY A O   1 
ATOM   1034 N  N   . TYR A 1 135 ? 6.83660   11.36267  9.13484   1.000 77.62097  ? 134 TYR A N   1 
ATOM   1035 C  CA  . TYR A 1 135 ? 7.88731   11.50319  8.13536   1.000 75.08460  ? 134 TYR A CA  1 
ATOM   1036 C  C   . TYR A 1 135 ? 7.79644   12.86803  7.45625   1.000 74.37393  ? 134 TYR A C   1 
ATOM   1037 O  O   . TYR A 1 135 ? 6.69945   13.31971  7.11603   1.000 69.61768  ? 134 TYR A O   1 
ATOM   1038 C  CB  . TYR A 1 135 ? 7.77534   10.40449  7.08299   1.000 72.06920  ? 134 TYR A CB  1 
ATOM   1039 C  CG  . TYR A 1 135 ? 8.65841   9.20924   7.34454   1.000 78.00408  ? 134 TYR A CG  1 
ATOM   1040 C  CD1 . TYR A 1 135 ? 9.97906   9.36839   7.73740   1.000 77.73188  ? 134 TYR A CD1 1 
ATOM   1041 C  CD2 . TYR A 1 135 ? 8.17142   7.92099   7.19835   1.000 72.96327  ? 134 TYR A CD2 1 
ATOM   1042 C  CE1 . TYR A 1 135 ? 10.79041  8.27374   7.97482   1.000 80.39151  ? 134 TYR A CE1 1 
ATOM   1043 C  CE2 . TYR A 1 135 ? 8.97065   6.82346   7.43386   1.000 75.10338  ? 134 TYR A CE2 1 
ATOM   1044 C  CZ  . TYR A 1 135 ? 10.28179  7.00306   7.82229   1.000 74.86053  ? 134 TYR A CZ  1 
ATOM   1045 O  OH  . TYR A 1 135 ? 11.09100  5.91388   8.06230   1.000 74.06600  ? 134 TYR A OH  1 
ATOM   1046 N  N   . PRO A 1 136 ? 8.93224   13.54109  7.23938   1.000 73.11208  ? 135 PRO A N   1 
ATOM   1047 C  CA  . PRO A 1 136 ? 8.91357   14.78720  6.46039   1.000 76.06368  ? 135 PRO A CA  1 
ATOM   1048 C  C   . PRO A 1 136 ? 8.62615   14.51770  4.99431   1.000 71.95009  ? 135 PRO A C   1 
ATOM   1049 O  O   . PRO A 1 136 ? 8.36517   13.37217  4.61566   1.000 77.14037  ? 135 PRO A O   1 
ATOM   1050 C  CB  . PRO A 1 136 ? 10.32300  15.36352  6.66821   1.000 76.76269  ? 135 PRO A CB  1 
ATOM   1051 C  CG  . PRO A 1 136 ? 10.89599  14.61441  7.82897   1.000 79.55175  ? 135 PRO A CG  1 
ATOM   1052 C  CD  . PRO A 1 136 ? 10.26412  13.25578  7.79156   1.000 75.02865  ? 135 PRO A CD  1 
ATOM   1053 N  N   . GLU A 1 137 ? 8.65491   15.55205  4.16505   1.000 70.57807  ? 136 GLU A N   1 
ATOM   1054 C  CA  . GLU A 1 137 ? 8.44482   15.33771  2.74407   1.000 77.09021  ? 136 GLU A CA  1 
ATOM   1055 C  C   . GLU A 1 137 ? 9.63483   14.58380  2.15700   1.000 67.19863  ? 136 GLU A C   1 
ATOM   1056 O  O   . GLU A 1 137 ? 10.78255  14.85702  2.51841   1.000 74.03579  ? 136 GLU A O   1 
ATOM   1057 C  CB  . GLU A 1 137 ? 8.24640   16.66490  2.02128   1.000 72.96747  ? 136 GLU A CB  1 
ATOM   1058 C  CG  . GLU A 1 137 ? 6.95584   17.33410  2.42031   1.000 80.37622  ? 136 GLU A CG  1 
ATOM   1059 C  CD  . GLU A 1 137 ? 6.84637   18.77296  1.96516   1.000 98.51755  ? 136 GLU A CD  1 
ATOM   1060 O  OE1 . GLU A 1 137 ? 7.77487   19.27965  1.30043   1.000 111.26754 ? 136 GLU A OE1 1 
ATOM   1061 O  OE2 . GLU A 1 137 ? 5.81663   19.40332  2.28174   1.000 98.06219  ? 136 GLU A OE2 1 
ATOM   1062 N  N   . PRO A 1 138 ? 9.39642   13.61819  1.27293   1.000 64.52176  ? 137 PRO A N   1 
ATOM   1063 C  CA  . PRO A 1 138 ? 10.51081  12.81456  0.76053   1.000 64.47339  ? 137 PRO A CA  1 
ATOM   1064 C  C   . PRO A 1 138 ? 11.40936  13.62781  -0.15450  1.000 60.13978  ? 137 PRO A C   1 
ATOM   1065 O  O   . PRO A 1 138 ? 10.95498  14.52372  -0.87143  1.000 60.08226  ? 137 PRO A O   1 
ATOM   1066 C  CB  . PRO A 1 138 ? 9.81064   11.68322  0.00083   1.000 57.65270  ? 137 PRO A CB  1 
ATOM   1067 C  CG  . PRO A 1 138 ? 8.51018   12.27317  -0.41741  1.000 64.44266  ? 137 PRO A CG  1 
ATOM   1068 C  CD  . PRO A 1 138 ? 8.10805   13.21850  0.67992   1.000 63.96411  ? 137 PRO A CD  1 
ATOM   1069 N  N   . ILE A 1 139 ? 12.69514  13.30892  -0.12293  1.000 56.09767  ? 138 ILE A N   1 
ATOM   1070 C  CA  . ILE A 1 139 ? 13.63920  13.91117  -1.05464  1.000 55.91832  ? 138 ILE A CA  1 
ATOM   1071 C  C   . ILE A 1 139 ? 13.81835  12.96614  -2.23601  1.000 61.07677  ? 138 ILE A C   1 
ATOM   1072 O  O   . ILE A 1 139 ? 13.92729  11.74488  -2.06433  1.000 53.28317  ? 138 ILE A O   1 
ATOM   1073 C  CB  . ILE A 1 139 ? 14.97632  14.23821  -0.35832  1.000 59.20849  ? 138 ILE A CB  1 
ATOM   1074 C  CG1 . ILE A 1 139 ? 15.77164  12.97711  -0.02440  1.000 60.27188  ? 138 ILE A CG1 1 
ATOM   1075 C  CG2 . ILE A 1 139 ? 14.72949  15.03825  0.91620   1.000 59.16799  ? 138 ILE A CG2 1 
ATOM   1076 C  CD1 . ILE A 1 139 ? 17.11995  13.28304  0.57483   1.000 74.69478  ? 138 ILE A CD1 1 
ATOM   1077 N  N   . VAL A 1 140 ? 13.79371  13.51859  -3.44554  1.000 57.57888  ? 139 VAL A N   1 
ATOM   1078 C  CA  . VAL A 1 140 ? 13.97593  12.70715  -4.64326  1.000 53.73055  ? 139 VAL A CA  1 
ATOM   1079 C  C   . VAL A 1 140 ? 15.46972  12.48657  -4.85099  1.000 53.66986  ? 139 VAL A C   1 
ATOM   1080 O  O   . VAL A 1 140 ? 16.24318  13.44422  -4.94609  1.000 55.90084  ? 139 VAL A O   1 
ATOM   1081 C  CB  . VAL A 1 140 ? 13.33911  13.37537  -5.86794  1.000 52.28929  ? 139 VAL A CB  1 
ATOM   1082 C  CG1 . VAL A 1 140 ? 13.43081  12.45691  -7.08090  1.000 59.81260  ? 139 VAL A CG1 1 
ATOM   1083 C  CG2 . VAL A 1 140 ? 11.89578  13.73404  -5.58842  1.000 48.14058  ? 139 VAL A CG2 1 
ATOM   1084 N  N   . ILE A 1 141 ? 15.88034  11.22450  -4.91351  1.000 54.79459  ? 140 ILE A N   1 
ATOM   1085 C  CA  . ILE A 1 141 ? 17.27332  10.84041  -5.10014  1.000 59.06020  ? 140 ILE A CA  1 
ATOM   1086 C  C   . ILE A 1 141 ? 17.42723  10.29862  -6.51168  1.000 70.99202  ? 140 ILE A C   1 
ATOM   1087 O  O   . ILE A 1 141 ? 16.60712  9.48991   -6.96827  1.000 64.44026  ? 140 ILE A O   1 
ATOM   1088 C  CB  . ILE A 1 141 ? 17.72250  9.78673   -4.06900  1.000 60.79240  ? 140 ILE A CB  1 
ATOM   1089 C  CG1 . ILE A 1 141 ? 17.43972  10.27117  -2.64888  1.000 60.54065  ? 140 ILE A CG1 1 
ATOM   1090 C  CG2 . ILE A 1 141 ? 19.20084  9.47206   -4.24506  1.000 62.41967  ? 140 ILE A CG2 1 
ATOM   1091 C  CD1 . ILE A 1 141 ? 18.32264  11.40015  -2.20806  1.000 53.59816  ? 140 ILE A CD1 1 
ATOM   1092 N  N   . GLU A 1 142 ? 18.48434  10.73527  -7.19603  1.000 64.25884  ? 141 GLU A N   1 
ATOM   1093 C  CA  . GLU A 1 142 ? 18.73626  10.36745  -8.58454  1.000 67.06606  ? 141 GLU A CA  1 
ATOM   1094 C  C   . GLU A 1 142 ? 20.01119  9.53864   -8.64831  1.000 66.83532  ? 141 GLU A C   1 
ATOM   1095 O  O   . GLU A 1 142 ? 21.10568  10.05619  -8.40418  1.000 67.37137  ? 141 GLU A O   1 
ATOM   1096 C  CB  . GLU A 1 142 ? 18.85018  11.61252  -9.46047  1.000 70.09167  ? 141 GLU A CB  1 
ATOM   1097 C  CG  . GLU A 1 142 ? 17.75434  12.62624  -9.21225  1.000 77.15029  ? 141 GLU A CG  1 
ATOM   1098 C  CD  . GLU A 1 142 ? 17.75905  13.74840  -10.22292 1.000 78.97622  ? 141 GLU A CD  1 
ATOM   1099 O  OE1 . GLU A 1 142 ? 18.52220  13.66250  -11.20882 1.000 79.62303  ? 141 GLU A OE1 1 
ATOM   1100 O  OE2 . GLU A 1 142 ? 16.99521  14.71735  -10.03449 1.000 72.53487  ? 141 GLU A OE2 1 
ATOM   1101 N  N   . GLN A 1 143 ? 19.86992  8.25435   -8.96167  1.000 68.24080  ? 142 GLN A N   1 
ATOM   1102 C  CA  . GLN A 1 143 ? 20.99984  7.38849   -9.26331  1.000 74.65387  ? 142 GLN A CA  1 
ATOM   1103 C  C   . GLN A 1 143 ? 20.80600  6.84035   -10.66817 1.000 72.98052  ? 142 GLN A C   1 
ATOM   1104 O  O   . GLN A 1 143 ? 19.78059  6.21308   -10.95626 1.000 68.91106  ? 142 GLN A O   1 
ATOM   1105 C  CB  . GLN A 1 143 ? 21.12805  6.24815   -8.24877  1.000 70.93263  ? 142 GLN A CB  1 
ATOM   1106 C  CG  . GLN A 1 143 ? 22.35268  5.37260   -8.46788  1.000 57.63070  ? 142 GLN A CG  1 
ATOM   1107 C  CD  . GLN A 1 143 ? 23.63804  6.17770   -8.52798  1.000 71.14486  ? 142 GLN A CD  1 
ATOM   1108 O  OE1 . GLN A 1 143 ? 24.44355  6.01513   -9.44477  1.000 71.06385  ? 142 GLN A OE1 1 
ATOM   1109 N  NE2 . GLN A 1 143 ? 23.83579  7.05273   -7.54800  1.000 68.57796  ? 142 GLN A NE2 1 
ATOM   1110 N  N   . GLY A 1 144 ? 21.79257  7.06528   -11.53226 1.000 79.25167  ? 143 GLY A N   1 
ATOM   1111 C  CA  . GLY A 1 144 ? 21.58579  6.78245   -12.94348 1.000 81.43555  ? 143 GLY A CA  1 
ATOM   1112 C  C   . GLY A 1 144 ? 20.42639  7.61707   -13.44871 1.000 80.86711  ? 143 GLY A C   1 
ATOM   1113 O  O   . GLY A 1 144 ? 20.39598  8.84180   -13.28366 1.000 83.72315  ? 143 GLY A O   1 
ATOM   1114 N  N   . ASN A 1 145 ? 19.45056  6.95751   -14.06665 1.000 87.44570  ? 144 ASN A N   1 
ATOM   1115 C  CA  . ASN A 1 145 ? 18.19216  7.59962   -14.41829 1.000 89.69251  ? 144 ASN A CA  1 
ATOM   1116 C  C   . ASN A 1 145 ? 17.06131  7.19796   -13.48353 1.000 90.56450  ? 144 ASN A C   1 
ATOM   1117 O  O   . ASN A 1 145 ? 15.92812  7.65205   -13.66557 1.000 86.35586  ? 144 ASN A O   1 
ATOM   1118 C  CB  . ASN A 1 145 ? 17.81235  7.27771   -15.86439 1.000 95.37635  ? 144 ASN A CB  1 
ATOM   1119 C  CG  . ASN A 1 145 ? 18.87198  7.72104   -16.85129 1.000 96.89417  ? 144 ASN A CG  1 
ATOM   1120 O  OD1 . ASN A 1 145 ? 20.00284  8.02683   -16.46737 1.000 98.79565  ? 144 ASN A OD1 1 
ATOM   1121 N  ND2 . ASN A 1 145 ? 18.51878  7.74934   -18.12779 1.000 95.29756  ? 144 ASN A ND2 1 
ATOM   1122 N  N   . TYR A 1 146 ? 17.34654  6.36147   -12.49063 1.000 84.91186  ? 145 TYR A N   1 
ATOM   1123 C  CA  . TYR A 1 146 ? 16.36004  5.95785   -11.50217 1.000 76.49260  ? 145 TYR A CA  1 
ATOM   1124 C  C   . TYR A 1 146 ? 16.24502  7.03784   -10.43401 1.000 71.35775  ? 145 TYR A C   1 
ATOM   1125 O  O   . TYR A 1 146 ? 17.25276  7.60515   -10.00377 1.000 71.11963  ? 145 TYR A O   1 
ATOM   1126 C  CB  . TYR A 1 146 ? 16.77307  4.62007   -10.89117 1.000 75.57735  ? 145 TYR A CB  1 
ATOM   1127 C  CG  . TYR A 1 146 ? 15.68928  3.89940   -10.13121 1.000 69.54119  ? 145 TYR A CG  1 
ATOM   1128 C  CD1 . TYR A 1 146 ? 14.64002  3.28240   -10.79506 1.000 65.61154  ? 145 TYR A CD1 1 
ATOM   1129 C  CD2 . TYR A 1 146 ? 15.73340  3.80739   -8.74951  1.000 68.19528  ? 145 TYR A CD2 1 
ATOM   1130 C  CE1 . TYR A 1 146 ? 13.65282  2.61124   -10.10008 1.000 72.62533  ? 145 TYR A CE1 1 
ATOM   1131 C  CE2 . TYR A 1 146 ? 14.75463  3.13919   -8.04803  1.000 64.49039  ? 145 TYR A CE2 1 
ATOM   1132 C  CZ  . TYR A 1 146 ? 13.71466  2.54386   -8.72588  1.000 66.32585  ? 145 TYR A CZ  1 
ATOM   1133 O  OH  . TYR A 1 146 ? 12.73988  1.87330   -8.02576  1.000 65.22084  ? 145 TYR A OH  1 
ATOM   1134 N  N   . LYS A 1 147 ? 15.01710  7.34907   -10.03197 1.000 69.51419  ? 146 LYS A N   1 
ATOM   1135 C  CA  . LYS A 1 147 ? 14.76792  8.33151   -8.98628  1.000 70.41985  ? 146 LYS A CA  1 
ATOM   1136 C  C   . LYS A 1 147 ? 13.83322  7.71509   -7.95996  1.000 70.77153  ? 146 LYS A C   1 
ATOM   1137 O  O   . LYS A 1 147 ? 12.84814  7.06473   -8.32542  1.000 66.02607  ? 146 LYS A O   1 
ATOM   1138 C  CB  . LYS A 1 147 ? 14.16613  9.62438   -9.55042  1.000 68.86598  ? 146 LYS A CB  1 
ATOM   1139 C  CG  . LYS A 1 147 ? 15.10977  10.40174  -10.45647 1.000 72.03420  ? 146 LYS A CG  1 
ATOM   1140 C  CD  . LYS A 1 147 ? 14.56342  11.78642  -10.78000 1.000 73.98548  ? 146 LYS A CD  1 
ATOM   1141 C  CE  . LYS A 1 147 ? 13.36248  11.72715  -11.70711 1.000 76.11676  ? 146 LYS A CE  1 
ATOM   1142 N  NZ  . LYS A 1 147 ? 13.74589  11.35732  -13.09604 1.000 78.75362  ? 146 LYS A NZ  1 
ATOM   1143 N  N   . PHE A 1 148 ? 14.14965  7.90382   -6.68125  1.000 65.83140  ? 147 PHE A N   1 
ATOM   1144 C  CA  . PHE A 1 148 ? 13.31970  7.34165   -5.62344  1.000 60.53109  ? 147 PHE A CA  1 
ATOM   1145 C  C   . PHE A 1 148 ? 13.17387  8.33294   -4.47647  1.000 55.56514  ? 147 PHE A C   1 
ATOM   1146 O  O   . PHE A 1 148 ? 14.04591  9.16568   -4.23577  1.000 58.91174  ? 147 PHE A O   1 
ATOM   1147 C  CB  . PHE A 1 148 ? 13.87149  5.99245   -5.12460  1.000 53.87173  ? 147 PHE A CB  1 
ATOM   1148 C  CG  . PHE A 1 148 ? 15.26780  6.05584   -4.56587  1.000 52.92632  ? 147 PHE A CG  1 
ATOM   1149 C  CD1 . PHE A 1 148 ? 16.36998  6.13361   -5.40465  1.000 55.58488  ? 147 PHE A CD1 1 
ATOM   1150 C  CD2 . PHE A 1 148 ? 15.47768  5.98104   -3.19819  1.000 51.66227  ? 147 PHE A CD2 1 
ATOM   1151 C  CE1 . PHE A 1 148 ? 17.64833  6.16860   -4.88540  1.000 57.13946  ? 147 PHE A CE1 1 
ATOM   1152 C  CE2 . PHE A 1 148 ? 16.75079  6.01359   -2.67271  1.000 51.28197  ? 147 PHE A CE2 1 
ATOM   1153 C  CZ  . PHE A 1 148 ? 17.83839  6.10708   -3.51494  1.000 48.70660  ? 147 PHE A CZ  1 
ATOM   1154 N  N   . ASN A 1 149 ? 12.05242  8.23223   -3.77060  1.000 53.35341  ? 148 ASN A N   1 
ATOM   1155 C  CA  . ASN A 1 149 ? 11.72142  9.14323   -2.68039  1.000 56.41852  ? 148 ASN A CA  1 
ATOM   1156 C  C   . ASN A 1 149 ? 12.26406  8.57891   -1.37051  1.000 51.77193  ? 148 ASN A C   1 
ATOM   1157 O  O   . ASN A 1 149 ? 11.77165  7.56270   -0.86814  1.000 57.55531  ? 148 ASN A O   1 
ATOM   1158 C  CB  . ASN A 1 149 ? 10.21216  9.36810   -2.61052  1.000 61.78879  ? 148 ASN A CB  1 
ATOM   1159 C  CG  . ASN A 1 149 ? 9.73008   10.37380  -3.63861  1.000 56.74107  ? 148 ASN A CG  1 
ATOM   1160 O  OD1 . ASN A 1 149 ? 10.53622  11.01989  -4.30740  1.000 65.91319  ? 148 ASN A OD1 1 
ATOM   1161 N  ND2 . ASN A 1 149 ? 8.41399   10.52550  -3.75753  1.000 53.45419  ? 148 ASN A ND2 1 
ATOM   1162 N  N   . LEU A 1 150 ? 13.29457  9.22764   -0.83252  1.000 50.56033  ? 149 LEU A N   1 
ATOM   1163 C  CA  . LEU A 1 150 ? 13.83444  8.87744   0.47284   1.000 49.86945  ? 149 LEU A CA  1 
ATOM   1164 C  C   . LEU A 1 150 ? 13.05881  9.60949   1.55860   1.000 57.20271  ? 149 LEU A C   1 
ATOM   1165 O  O   . LEU A 1 150 ? 12.84030  10.82380  1.46965   1.000 63.22328  ? 149 LEU A O   1 
ATOM   1166 C  CB  . LEU A 1 150 ? 15.32160  9.22965   0.55220   1.000 44.94647  ? 149 LEU A CB  1 
ATOM   1167 C  CG  . LEU A 1 150 ? 16.04989  8.96835   1.87282   1.000 58.56947  ? 149 LEU A CG  1 
ATOM   1168 C  CD1 . LEU A 1 150 ? 15.93243  7.50591   2.28884   1.000 49.07842  ? 149 LEU A CD1 1 
ATOM   1169 C  CD2 . LEU A 1 150 ? 17.51649  9.38550   1.78449   1.000 51.90027  ? 149 LEU A CD2 1 
ATOM   1170 N  N   . SER A 1 151 ? 12.62553  8.86169   2.56759   1.000 56.08908  ? 150 SER A N   1 
ATOM   1171 C  CA  . SER A 1 151 ? 11.95276  9.40495   3.73771   1.000 50.91908  ? 150 SER A CA  1 
ATOM   1172 C  C   . SER A 1 151 ? 12.83487  9.18695   4.95779   1.000 59.08935  ? 150 SER A C   1 
ATOM   1173 O  O   . SER A 1 151 ? 13.28261  8.06263   5.21174   1.000 67.06855  ? 150 SER A O   1 
ATOM   1174 C  CB  . SER A 1 151 ? 10.58581  8.74762   3.94443   1.000 48.34799  ? 150 SER A CB  1 
ATOM   1175 O  OG  . SER A 1 151 ? 9.67848   9.13393   2.92572   1.000 65.57084  ? 150 SER A OG  1 
ATOM   1176 N  N   . ALA A 1 152 ? 13.08754  10.26269  5.70147   1.000 50.78459  ? 151 ALA A N   1 
ATOM   1177 C  CA  . ALA A 1 152 ? 13.92327  10.20332  6.89111   1.000 53.99713  ? 151 ALA A CA  1 
ATOM   1178 C  C   . ALA A 1 152 ? 13.50286  11.29816  7.85943   1.000 62.21697  ? 151 ALA A C   1 
ATOM   1179 O  O   . ALA A 1 152 ? 13.32170  12.45016  7.45972   1.000 59.62117  ? 151 ALA A O   1 
ATOM   1180 C  CB  . ALA A 1 152 ? 15.40686  10.35560  6.54140   1.000 45.47534  ? 151 ALA A CB  1 
ATOM   1181 N  N   . ALA A 1 153 ? 13.37440  10.93467  9.13438   1.000 62.56171  ? 152 ALA A N   1 
ATOM   1182 C  CA  . ALA A 1 153 ? 13.01719  11.86492  10.20124  1.000 62.17533  ? 152 ALA A CA  1 
ATOM   1183 C  C   . ALA A 1 153 ? 14.20335  12.01094  11.14302  1.000 52.71191  ? 152 ALA A C   1 
ATOM   1184 O  O   . ALA A 1 153 ? 14.71834  11.01146  11.65777  1.000 47.96553  ? 152 ALA A O   1 
ATOM   1185 C  CB  . ALA A 1 153 ? 11.78064  11.38675  10.96803  1.000 50.33376  ? 152 ALA A CB  1 
ATOM   1186 N  N   . PHE A 1 154 ? 14.63983  13.25008  11.35584  1.000 58.18387  ? 153 PHE A N   1 
ATOM   1187 C  CA  . PHE A 1 154 ? 15.75497  13.53840  12.24656  1.000 54.23836  ? 153 PHE A CA  1 
ATOM   1188 C  C   . PHE A 1 154 ? 15.20777  13.82402  13.63895  1.000 53.98201  ? 153 PHE A C   1 
ATOM   1189 O  O   . PHE A 1 154 ? 14.41006  14.74949  13.81913  1.000 60.83892  ? 153 PHE A O   1 
ATOM   1190 C  CB  . PHE A 1 154 ? 16.57064  14.72572  11.73582  1.000 55.39625  ? 153 PHE A CB  1 
ATOM   1191 C  CG  . PHE A 1 154 ? 17.16208  14.52231  10.36547  1.000 61.98396  ? 153 PHE A CG  1 
ATOM   1192 C  CD1 . PHE A 1 154 ? 17.43975  13.25182  9.89180   1.000 59.77043  ? 153 PHE A CD1 1 
ATOM   1193 C  CD2 . PHE A 1 154 ? 17.44445  15.61003  9.55423   1.000 63.48769  ? 153 PHE A CD2 1 
ATOM   1194 C  CE1 . PHE A 1 154 ? 17.98230  13.06724  8.63685   1.000 57.34412  ? 153 PHE A CE1 1 
ATOM   1195 C  CE2 . PHE A 1 154 ? 17.98758  15.43189  8.29603   1.000 67.90560  ? 153 PHE A CE2 1 
ATOM   1196 C  CZ  . PHE A 1 154 ? 18.25657  14.15798  7.83829   1.000 65.68082  ? 153 PHE A CZ  1 
ATOM   1197 N  N   . ASP A 1 155 ? 15.61965  13.01877  14.61880  1.000 61.26351  ? 154 ASP A N   1 
ATOM   1198 C  CA  . ASP A 1 155 ? 15.19701  13.27432  15.99217  1.000 55.78413  ? 154 ASP A CA  1 
ATOM   1199 C  C   . ASP A 1 155 ? 15.77757  14.58144  16.51281  1.000 60.53293  ? 154 ASP A C   1 
ATOM   1200 O  O   . ASP A 1 155 ? 15.10531  15.31419  17.24813  1.000 63.79150  ? 154 ASP A O   1 
ATOM   1201 C  CB  . ASP A 1 155 ? 15.57267  12.10220  16.89855  1.000 55.81221  ? 154 ASP A CB  1 
ATOM   1202 C  CG  . ASP A 1 155 ? 14.53624  10.99409  16.85774  1.000 69.24985  ? 154 ASP A CG  1 
ATOM   1203 O  OD1 . ASP A 1 155 ? 13.50243  11.17811  16.17864  1.000 72.10384  ? 154 ASP A OD1 1 
ATOM   1204 O  OD2 . ASP A 1 155 ? 14.74272  9.93999   17.49405  1.000 68.07024  ? 154 ASP A OD2 1 
ATOM   1205 N  N   . CYS A 1 156 ? 17.01687  14.89854  16.14116  1.000 57.18155  ? 155 CYS A N   1 
ATOM   1206 C  CA  . CYS A 1 156 ? 17.55737  16.20097  16.50000  1.000 56.76260  ? 155 CYS A CA  1 
ATOM   1207 C  C   . CYS A 1 156 ? 18.63882  16.60375  15.51207  1.000 56.78768  ? 155 CYS A C   1 
ATOM   1208 O  O   . CYS A 1 156 ? 19.40648  15.76644  15.03280  1.000 60.96671  ? 155 CYS A O   1 
ATOM   1209 C  CB  . CYS A 1 156 ? 18.12467  16.20540  17.92106  1.000 60.63136  ? 155 CYS A CB  1 
ATOM   1210 S  SG  . CYS A 1 156 ? 18.80744  17.80601  18.42683  1.000 80.28641  ? 155 CYS A SG  1 
ATOM   1211 N  N   . ILE A 1 157 ? 18.68947  17.90308  15.22665  1.000 49.41301  ? 156 ILE A N   1 
ATOM   1212 C  CA  . ILE A 1 157 ? 19.73407  18.51482  14.41666  1.000 58.36314  ? 156 ILE A CA  1 
ATOM   1213 C  C   . ILE A 1 157 ? 20.33095  19.65597  15.22499  1.000 66.79499  ? 156 ILE A C   1 
ATOM   1214 O  O   . ILE A 1 157 ? 19.59420  20.53845  15.68468  1.000 64.83305  ? 156 ILE A O   1 
ATOM   1215 C  CB  . ILE A 1 157 ? 19.19188  19.05591  13.07774  1.000 62.80892  ? 156 ILE A CB  1 
ATOM   1216 C  CG1 . ILE A 1 157 ? 18.02470  18.21031  12.55583  1.000 60.23295  ? 156 ILE A CG1 1 
ATOM   1217 C  CG2 . ILE A 1 157 ? 20.31048  19.14864  12.04359  1.000 60.42120  ? 156 ILE A CG2 1 
ATOM   1218 C  CD1 . ILE A 1 157 ? 17.18831  18.92594  11.50069  1.000 70.77025  ? 156 ILE A CD1 1 
ATOM   1219 N  N   . PHE A 1 158 ? 21.65478  19.64694  15.39501  1.000 66.37521  ? 157 PHE A N   1 
ATOM   1220 C  CA  . PHE A 1 158 ? 22.33766  20.79175  15.98757  1.000 59.61986  ? 157 PHE A CA  1 
ATOM   1221 C  C   . PHE A 1 158 ? 23.58062  21.12305  15.17132  1.000 66.82164  ? 157 PHE A C   1 
ATOM   1222 O  O   . PHE A 1 158 ? 23.95628  20.39848  14.24685  1.000 71.65431  ? 157 PHE A O   1 
ATOM   1223 C  CB  . PHE A 1 158 ? 22.67410  20.57190  17.48074  1.000 59.36198  ? 157 PHE A CB  1 
ATOM   1224 C  CG  . PHE A 1 158 ? 23.76435  19.55830  17.75682  1.000 63.50335  ? 157 PHE A CG  1 
ATOM   1225 C  CD1 . PHE A 1 158 ? 25.10743  19.92063  17.73598  1.000 61.58265  ? 157 PHE A CD1 1 
ATOM   1226 C  CD2 . PHE A 1 158 ? 23.43645  18.26183  18.12306  1.000 64.20644  ? 157 PHE A CD2 1 
ATOM   1227 C  CE1 . PHE A 1 158 ? 26.09841  18.99147  18.02113  1.000 61.84620  ? 157 PHE A CE1 1 
ATOM   1228 C  CE2 . PHE A 1 158 ? 24.41966  17.33313  18.41032  1.000 56.85537  ? 157 PHE A CE2 1 
ATOM   1229 C  CZ  . PHE A 1 158 ? 25.75102  17.69808  18.36374  1.000 62.95788  ? 157 PHE A CZ  1 
ATOM   1230 N  N   . ARG A 1 159 ? 24.18541  22.26812  15.48099  1.000 67.35224  ? 158 ARG A N   1 
ATOM   1231 C  CA  . ARG A 1 159 ? 25.38373  22.73687  14.79679  1.000 71.16277  ? 158 ARG A CA  1 
ATOM   1232 C  C   . ARG A 1 159 ? 26.52615  22.80524  15.79788  1.000 71.55971  ? 158 ARG A C   1 
ATOM   1233 O  O   . ARG A 1 159 ? 26.42226  23.49556  16.81677  1.000 73.53608  ? 158 ARG A O   1 
ATOM   1234 C  CB  . ARG A 1 159 ? 25.15554  24.10290  14.14803  1.000 67.67824  ? 158 ARG A CB  1 
ATOM   1235 C  CG  . ARG A 1 159 ? 26.28201  24.53287  13.21560  1.000 70.41038  ? 158 ARG A CG  1 
ATOM   1236 C  CD  . ARG A 1 159 ? 26.00149  25.86599  12.53485  1.000 70.21205  ? 158 ARG A CD  1 
ATOM   1237 N  NE  . ARG A 1 159 ? 24.88717  25.78634  11.59840  1.000 72.46395  ? 158 ARG A NE  1 
ATOM   1238 C  CZ  . ARG A 1 159 ? 23.74371  26.44360  11.73594  1.000 69.61423  ? 158 ARG A CZ  1 
ATOM   1239 N  NH1 . ARG A 1 159 ? 23.53285  27.26109  12.75476  1.000 72.91568  ? 158 ARG A NH1 1 
ATOM   1240 N  NH2 . ARG A 1 159 ? 22.79215  26.28694  10.82137  1.000 71.28615  ? 158 ARG A NH2 1 
ATOM   1241 N  N   . GLU A 1 160 ? 27.60974  22.09441  15.50461  1.000 77.31806  ? 159 GLU A N   1 
ATOM   1242 C  CA  . GLU A 1 160 ? 28.78999  22.15470  16.34664  1.000 77.36932  ? 159 GLU A CA  1 
ATOM   1243 C  C   . GLU A 1 160 ? 29.48674  23.50350  16.17425  1.000 79.51107  ? 159 GLU A C   1 
ATOM   1244 O  O   . GLU A 1 160 ? 29.17088  24.28952  15.27595  1.000 74.97551  ? 159 GLU A O   1 
ATOM   1245 C  CB  . GLU A 1 160 ? 29.75446  21.02061  16.00872  1.000 78.23297  ? 159 GLU A CB  1 
ATOM   1246 C  CG  . GLU A 1 160 ? 29.25284  19.62100  16.29058  1.000 80.04695  ? 159 GLU A CG  1 
ATOM   1247 C  CD  . GLU A 1 160 ? 30.24577  18.57517  15.82608  1.000 93.18536  ? 159 GLU A CD  1 
ATOM   1248 O  OE1 . GLU A 1 160 ? 31.16355  18.93806  15.05798  1.000 89.77033  ? 159 GLU A OE1 1 
ATOM   1249 O  OE2 . GLU A 1 160 ? 30.12069  17.39886  16.22699  1.000 94.24751  ? 159 GLU A OE2 1 
ATOM   1250 N  N   . ALA A 1 161 ? 30.44868  23.76927  17.06163  1.000 88.40017  ? 160 ALA A N   1 
ATOM   1251 C  CA  . ALA A 1 161 ? 31.17192  25.03680  17.01749  1.000 85.33147  ? 160 ALA A CA  1 
ATOM   1252 C  C   . ALA A 1 161 ? 31.89904  25.21880  15.69202  1.000 83.91069  ? 160 ALA A C   1 
ATOM   1253 O  O   . ALA A 1 161 ? 31.97747  26.33624  15.16726  1.000 83.38863  ? 160 ALA A O   1 
ATOM   1254 C  CB  . ALA A 1 161 ? 32.15213  25.11946  18.18513  1.000 77.60780  ? 160 ALA A CB  1 
ATOM   1255 N  N   . ASP A 1 162 ? 32.43742  24.13372  15.13741  1.000 83.03971  ? 161 ASP A N   1 
ATOM   1256 C  CA  . ASP A 1 162 ? 33.14987  24.13673  13.85977  1.000 84.92502  ? 161 ASP A CA  1 
ATOM   1257 C  C   . ASP A 1 162 ? 32.23142  24.32722  12.65237  1.000 88.42343  ? 161 ASP A C   1 
ATOM   1258 O  O   . ASP A 1 162 ? 32.73315  24.21294  11.52137  1.000 90.93634  ? 161 ASP A O   1 
ATOM   1259 C  CB  . ASP A 1 162 ? 33.95154  22.84073  13.71268  1.000 85.71554  ? 161 ASP A CB  1 
ATOM   1260 C  CG  . ASP A 1 162 ? 33.10392  21.60191  13.92059  1.000 85.43414  ? 161 ASP A CG  1 
ATOM   1261 O  OD1 . ASP A 1 162 ? 31.86611  21.73254  13.96862  1.000 86.59474  ? 161 ASP A OD1 1 
ATOM   1262 O  OD2 . ASP A 1 162 ? 33.67094  20.49667  14.04515  1.000 89.23788  ? 161 ASP A OD2 1 
ATOM   1263 N  N   . ASP A 1 163 ? 30.94587  24.60377  12.88609  1.000 80.49534  ? 162 ASP A N   1 
ATOM   1264 C  CA  . ASP A 1 163 ? 29.94017  24.73921  11.82937  1.000 83.79097  ? 162 ASP A CA  1 
ATOM   1265 C  C   . ASP A 1 163 ? 29.70317  23.42318  11.09264  1.000 84.27410  ? 162 ASP A C   1 
ATOM   1266 O  O   . ASP A 1 163 ? 29.40921  23.41409  9.89513   1.000 88.10734  ? 162 ASP A O   1 
ATOM   1267 C  CB  . ASP A 1 163 ? 30.30277  25.85103  10.83833  1.000 86.22059  ? 162 ASP A CB  1 
ATOM   1268 C  CG  . ASP A 1 163 ? 29.90552  27.22405  11.33599  1.000 84.24158  ? 162 ASP A CG  1 
ATOM   1269 O  OD1 . ASP A 1 163 ? 29.53809  27.34892  12.52451  1.000 96.06915  ? 162 ASP A OD1 1 
ATOM   1270 O  OD2 . ASP A 1 163 ? 29.94797  28.18141  10.53648  1.000 84.53265  ? 162 ASP A OD2 1 
ATOM   1271 N  N   . THR A 1 164 ? 29.82996  22.30495  11.80143  1.000 83.39016  ? 163 THR A N   1 
ATOM   1272 C  CA  . THR A 1 164 ? 29.46373  21.00225  11.26663  1.000 79.39993  ? 163 THR A CA  1 
ATOM   1273 C  C   . THR A 1 164 ? 28.03118  20.67699  11.66742  1.000 74.17389  ? 163 THR A C   1 
ATOM   1274 O  O   . THR A 1 164 ? 27.63346  20.89151  12.81552  1.000 73.47238  ? 163 THR A O   1 
ATOM   1275 C  CB  . THR A 1 164 ? 30.41211  19.91701  11.78123  1.000 81.87160  ? 163 THR A CB  1 
ATOM   1276 O  OG1 . THR A 1 164 ? 31.72268  20.13114  11.24480  1.000 94.74594  ? 163 THR A OG1 1 
ATOM   1277 C  CG2 . THR A 1 164 ? 29.91727  18.53166  11.38209  1.000 77.84720  ? 163 THR A CG2 1 
ATOM   1278 N  N   . ILE A 1 165 ? 27.25454  20.16914  10.71582  1.000 73.60162  ? 164 ILE A N   1 
ATOM   1279 C  CA  . ILE A 1 165 ? 25.87694  19.77742  10.99357  1.000 69.54479  ? 164 ILE A CA  1 
ATOM   1280 C  C   . ILE A 1 165 ? 25.89576  18.39749  11.64072  1.000 64.69550  ? 164 ILE A C   1 
ATOM   1281 O  O   . ILE A 1 165 ? 26.42849  17.44027  11.06813  1.000 67.30271  ? 164 ILE A O   1 
ATOM   1282 C  CB  . ILE A 1 165 ? 25.03084  19.77437  9.71331   1.000 65.04280  ? 164 ILE A CB  1 
ATOM   1283 C  CG1 . ILE A 1 165 ? 25.31197  21.02225  8.86961   1.000 64.36371  ? 164 ILE A CG1 1 
ATOM   1284 C  CG2 . ILE A 1 165 ? 23.54981  19.66531  10.05975  1.000 60.81752  ? 164 ILE A CG2 1 
ATOM   1285 C  CD1 . ILE A 1 165 ? 24.95967  22.33125  9.53952   1.000 72.26745  ? 164 ILE A CD1 1 
ATOM   1286 N  N   . HIS A 1 166 ? 25.32503  18.29113  12.83935  1.000 61.97119  ? 165 HIS A N   1 
ATOM   1287 C  CA  . HIS A 1 166 ? 25.30363  17.04863  13.59543  1.000 62.37432  ? 165 HIS A CA  1 
ATOM   1288 C  C   . HIS A 1 166 ? 23.86782  16.55104  13.68513  1.000 62.03056  ? 165 HIS A C   1 
ATOM   1289 O  O   . HIS A 1 166 ? 23.00110  17.22970  14.25616  1.000 64.84640  ? 165 HIS A O   1 
ATOM   1290 C  CB  . HIS A 1 166 ? 25.89829  17.25874  14.98552  1.000 63.09451  ? 165 HIS A CB  1 
ATOM   1291 C  CG  . HIS A 1 166 ? 26.36857  15.99999  15.64495  1.000 61.78940  ? 165 HIS A CG  1 
ATOM   1292 N  ND1 . HIS A 1 166 ? 27.66565  15.83031  16.07988  1.000 66.53366  ? 165 HIS A ND1 1 
ATOM   1293 C  CD2 . HIS A 1 166 ? 25.71412  14.85885  15.96313  1.000 63.03158  ? 165 HIS A CD2 1 
ATOM   1294 C  CE1 . HIS A 1 166 ? 27.79407  14.63512  16.62672  1.000 57.87454  ? 165 HIS A CE1 1 
ATOM   1295 N  NE2 . HIS A 1 166 ? 26.62397  14.02542  16.56897  1.000 68.45175  ? 165 HIS A NE2 1 
ATOM   1296 N  N   . ILE A 1 167 ? 23.62211  15.38239  13.10254  1.000 58.37959  ? 166 ILE A N   1 
ATOM   1297 C  CA  . ILE A 1 167 ? 22.34100  14.69843  13.21351  1.000 57.84589  ? 166 ILE A CA  1 
ATOM   1298 C  C   . ILE A 1 167 ? 22.44730  13.72314  14.37801  1.000 57.96690  ? 166 ILE A C   1 
ATOM   1299 O  O   . ILE A 1 167 ? 23.35071  12.88081  14.41137  1.000 53.24414  ? 166 ILE A O   1 
ATOM   1300 C  CB  . ILE A 1 167 ? 21.98525  13.96371  11.91164  1.000 51.75740  ? 166 ILE A CB  1 
ATOM   1301 C  CG1 . ILE A 1 167 ? 22.42770  14.77543  10.68632  1.000 53.98537  ? 166 ILE A CG1 1 
ATOM   1302 C  CG2 . ILE A 1 167 ? 20.49032  13.64471  11.86626  1.000 54.38281  ? 166 ILE A CG2 1 
ATOM   1303 C  CD1 . ILE A 1 167 ? 21.42276  15.79698  10.21296  1.000 54.76780  ? 166 ILE A CD1 1 
ATOM   1304 N  N   . LEU A 1 168 ? 21.54289  13.84603  15.34386  1.000 59.83107  ? 167 LEU A N   1 
ATOM   1305 C  CA  . LEU A 1 168 ? 21.51815  12.98287  16.51547  1.000 58.32074  ? 167 LEU A CA  1 
ATOM   1306 C  C   . LEU A 1 168 ? 20.19683  12.23307  16.53268  1.000 57.97408  ? 167 LEU A C   1 
ATOM   1307 O  O   . LEU A 1 168 ? 19.12614  12.85366  16.50205  1.000 53.65177  ? 167 LEU A O   1 
ATOM   1308 C  CB  . LEU A 1 168 ? 21.69343  13.79833  17.79666  1.000 56.46106  ? 167 LEU A CB  1 
ATOM   1309 C  CG  . LEU A 1 168 ? 21.62086  13.06837  19.13708  1.000 56.50321  ? 167 LEU A CG  1 
ATOM   1310 C  CD1 . LEU A 1 168 ? 22.80957  12.13734  19.32614  1.000 55.46670  ? 167 LEU A CD1 1 
ATOM   1311 C  CD2 . LEU A 1 168 ? 21.52357  14.06756  20.27870  1.000 62.24209  ? 167 LEU A CD2 1 
ATOM   1312 N  N   . ASP A 1 169 ? 20.27545  10.90708  16.57233  1.000 50.87670  ? 168 ASP A N   1 
ATOM   1313 C  CA  . ASP A 1 169 ? 19.11049  10.05574  16.74849  1.000 58.70175  ? 168 ASP A CA  1 
ATOM   1314 C  C   . ASP A 1 169 ? 19.04826  9.62960   18.20676  1.000 61.28794  ? 168 ASP A C   1 
ATOM   1315 O  O   . ASP A 1 169 ? 20.05627  9.20045   18.77606  1.000 53.76371  ? 168 ASP A O   1 
ATOM   1316 C  CB  . ASP A 1 169 ? 19.16954  8.83427   15.83090  1.000 59.51903  ? 168 ASP A CB  1 
ATOM   1317 C  CG  . ASP A 1 169 ? 17.95908  7.94461   15.98076  1.000 64.50048  ? 168 ASP A CG  1 
ATOM   1318 O  OD1 . ASP A 1 169 ? 16.82821  8.45362   15.84735  1.000 64.93763  ? 168 ASP A OD1 1 
ATOM   1319 O  OD2 . ASP A 1 169 ? 18.13177  6.73843   16.24248  1.000 68.39111  ? 168 ASP A OD2 1 
ATOM   1320 N  N   . LEU A 1 170 ? 17.87593  9.76648   18.81038  1.000 65.01567  ? 169 LEU A N   1 
ATOM   1321 C  CA  . LEU A 1 170 ? 17.69641  9.50815   20.23096  1.000 68.05102  ? 169 LEU A CA  1 
ATOM   1322 C  C   . LEU A 1 170 ? 17.02978  8.15311   20.40589  1.000 67.72763  ? 169 LEU A C   1 
ATOM   1323 O  O   . LEU A 1 170 ? 15.94014  7.91691   19.87340  1.000 67.17570  ? 169 LEU A O   1 
ATOM   1324 C  CB  . LEU A 1 170 ? 16.87471  10.61875  20.88145  1.000 61.81570  ? 169 LEU A CB  1 
ATOM   1325 C  CG  . LEU A 1 170 ? 17.65381  11.93111  20.86355  1.000 65.86879  ? 169 LEU A CG  1 
ATOM   1326 C  CD1 . LEU A 1 170 ? 16.87504  13.05559  21.53187  1.000 67.68173  ? 169 LEU A CD1 1 
ATOM   1327 C  CD2 . LEU A 1 170 ? 19.00660  11.71595  21.53161  1.000 67.30181  ? 169 LEU A CD2 1 
ATOM   1328 N  N   . LYS A 1 171 ? 17.68566  7.27023   21.14936  1.000 69.40932  ? 170 LYS A N   1 
ATOM   1329 C  CA  . LYS A 1 171 ? 17.23998  5.89745   21.30354  1.000 69.46188  ? 170 LYS A CA  1 
ATOM   1330 C  C   . LYS A 1 171 ? 17.02072  5.57548   22.77290  1.000 70.35840  ? 170 LYS A C   1 
ATOM   1331 O  O   . LYS A 1 171 ? 17.45166  6.31063   23.66464  1.000 68.99817  ? 170 LYS A O   1 
ATOM   1332 C  CB  . LYS A 1 171 ? 18.25113  4.90947   20.70394  1.000 59.86298  ? 170 LYS A CB  1 
ATOM   1333 C  CG  . LYS A 1 171 ? 18.38407  4.98217   19.19766  1.000 67.60663  ? 170 LYS A CG  1 
ATOM   1334 C  CD  . LYS A 1 171 ? 18.77339  3.62765   18.63403  1.000 72.85791  ? 170 LYS A CD  1 
ATOM   1335 C  CE  . LYS A 1 171 ? 18.69601  3.63031   17.12438  1.000 74.85613  ? 170 LYS A CE  1 
ATOM   1336 N  NZ  . LYS A 1 171 ? 17.49201  4.35059   16.63001  1.000 68.80464  ? 170 LYS A NZ  1 
ATOM   1337 N  N   . THR A 1 172 ? 16.32814  4.46319   23.00852  1.000 68.80486  ? 171 THR A N   1 
ATOM   1338 C  CA  . THR A 1 172 ? 16.07055  3.96415   24.34994  1.000 73.07038  ? 171 THR A CA  1 
ATOM   1339 C  C   . THR A 1 172 ? 16.17748  2.44465   24.32511  1.000 74.53010  ? 171 THR A C   1 
ATOM   1340 O  O   . THR A 1 172 ? 16.34103  1.82998   23.26607  1.000 71.04903  ? 171 THR A O   1 
ATOM   1341 C  CB  . THR A 1 172 ? 14.69775  4.42226   24.86690  1.000 67.24381  ? 171 THR A CB  1 
ATOM   1342 O  OG1 . THR A 1 172 ? 13.70606  4.21792   23.85328  1.000 69.26861  ? 171 THR A OG1 1 
ATOM   1343 C  CG2 . THR A 1 172 ? 14.72121  5.89384   25.24485  1.000 67.98136  ? 171 THR A CG2 1 
ATOM   1344 N  N   . GLY A 1 173 ? 16.09443  1.83886   25.50837  1.000 75.65248  ? 172 GLY A N   1 
ATOM   1345 C  CA  . GLY A 1 173 ? 16.10999  0.39713   25.62676  1.000 73.02198  ? 172 GLY A CA  1 
ATOM   1346 C  C   . GLY A 1 173 ? 17.45829  -0.20662  25.26041  1.000 77.83173  ? 172 GLY A C   1 
ATOM   1347 O  O   . GLY A 1 173 ? 18.49711  0.46133   25.22747  1.000 70.33371  ? 172 GLY A O   1 
ATOM   1348 N  N   . GLN A 1 174 ? 17.41886  -1.50726  24.97108  1.000 81.37232  ? 173 GLN A N   1 
ATOM   1349 C  CA  . GLN A 1 174 ? 18.60133  -2.26278  24.58062  1.000 82.91445  ? 173 GLN A CA  1 
ATOM   1350 C  C   . GLN A 1 174 ? 18.97067  -2.05158  23.11892  1.000 85.61144  ? 173 GLN A C   1 
ATOM   1351 O  O   . GLN A 1 174 ? 20.01028  -2.55751  22.68019  1.000 89.54037  ? 173 GLN A O   1 
ATOM   1352 C  CB  . GLN A 1 174 ? 18.37687  -3.75592  24.84588  1.000 89.62634  ? 173 GLN A CB  1 
ATOM   1353 C  CG  . GLN A 1 174 ? 19.64445  -4.59980  24.84579  1.000 96.08198  ? 173 GLN A CG  1 
ATOM   1354 C  CD  . GLN A 1 174 ? 19.36914  -6.07784  25.00837  1.000 113.10572 ? 173 GLN A CD  1 
ATOM   1355 O  OE1 . GLN A 1 174 ? 18.28482  -6.48209  25.43063  1.000 120.05528 ? 173 GLN A OE1 1 
ATOM   1356 N  NE2 . GLN A 1 174 ? 20.35536  -6.89658  24.67201  1.000 114.96786 ? 173 GLN A NE2 1 
ATOM   1357 N  N   . SER A 1 175 ? 18.14817  -1.32108  22.36693  1.000 86.53364  ? 174 SER A N   1 
ATOM   1358 C  CA  . SER A 1 175 ? 18.33764  -1.10919  20.93741  1.000 91.23019  ? 174 SER A CA  1 
ATOM   1359 C  C   . SER A 1 175 ? 19.78381  -0.76930  20.60785  1.000 89.99103  ? 174 SER A C   1 
ATOM   1360 O  O   . SER A 1 175 ? 20.35052  0.18206   21.15546  1.000 94.06175  ? 174 SER A O   1 
ATOM   1361 C  CB  . SER A 1 175 ? 17.41676  0.01859   20.46681  1.000 84.14324  ? 174 SER A CB  1 
ATOM   1362 O  OG  . SER A 1 175 ? 16.07966  -0.21106  20.87416  1.000 80.79867  ? 174 SER A OG  1 
ATOM   1363 N  N   . ASN A 1 176 ? 20.38712  -1.55326  19.71756  1.000 92.30491  ? 175 ASN A N   1 
ATOM   1364 C  CA  . ASN A 1 176 ? 21.74264  -1.27870  19.25990  1.000 89.72204  ? 175 ASN A CA  1 
ATOM   1365 C  C   . ASN A 1 176 ? 21.67850  -0.17613  18.20291  1.000 84.75537  ? 175 ASN A C   1 
ATOM   1366 O  O   . ASN A 1 176 ? 20.61569  0.38292   17.92004  1.000 84.82746  ? 175 ASN A O   1 
ATOM   1367 C  CB  . ASN A 1 176 ? 22.39898  -2.55550  18.73731  1.000 94.68770  ? 175 ASN A CB  1 
ATOM   1368 C  CG  . ASN A 1 176 ? 23.91939  -2.48652  18.75562  1.000 100.25448 ? 175 ASN A CG  1 
ATOM   1369 O  OD1 . ASN A 1 176 ? 24.50443  -1.40979  18.88095  1.000 95.78319  ? 175 ASN A OD1 1 
ATOM   1370 N  ND2 . ASN A 1 176 ? 24.56512  -3.64080  18.62148  1.000 87.29900  ? 175 ASN A ND2 1 
ATOM   1371 N  N   . PHE A 1 177 ? 22.81592  0.15902   17.60327  1.000 79.04698  ? 176 PHE A N   1 
ATOM   1372 C  CA  . PHE A 1 177 ? 22.89930  1.24084   16.62828  1.000 74.09374  ? 176 PHE A CA  1 
ATOM   1373 C  C   . PHE A 1 177 ? 23.18176  0.63761   15.25869  1.000 75.09081  ? 176 PHE A C   1 
ATOM   1374 O  O   . PHE A 1 177 ? 24.25993  0.07992   15.02777  1.000 68.01347  ? 176 PHE A O   1 
ATOM   1375 C  CB  . PHE A 1 177 ? 23.98012  2.24557   17.01891  1.000 68.56851  ? 176 PHE A CB  1 
ATOM   1376 C  CG  . PHE A 1 177 ? 23.77617  2.85838   18.37534  1.000 76.02837  ? 176 PHE A CG  1 
ATOM   1377 C  CD1 . PHE A 1 177 ? 22.50320  2.97929   18.90810  1.000 73.72237  ? 176 PHE A CD1 1 
ATOM   1378 C  CD2 . PHE A 1 177 ? 24.85445  3.31046   19.12148  1.000 67.14533  ? 176 PHE A CD2 1 
ATOM   1379 C  CE1 . PHE A 1 177 ? 22.30639  3.53609   20.15528  1.000 69.12456  ? 176 PHE A CE1 1 
ATOM   1380 C  CE2 . PHE A 1 177 ? 24.65805  3.87210   20.37397  1.000 67.55701  ? 176 PHE A CE2 1 
ATOM   1381 C  CZ  . PHE A 1 177 ? 23.38536  3.98367   20.88681  1.000 69.95208  ? 176 PHE A CZ  1 
ATOM   1382 N  N   . ASP A 1 178 ? 22.21421  0.74965   14.35517  1.000 70.73846  ? 177 ASP A N   1 
ATOM   1383 C  CA  . ASP A 1 178 ? 22.38503  0.32200   12.97176  1.000 57.98780  ? 177 ASP A CA  1 
ATOM   1384 C  C   . ASP A 1 178 ? 22.92338  1.50887   12.17900  1.000 53.98039  ? 177 ASP A C   1 
ATOM   1385 O  O   . ASP A 1 178 ? 22.19331  2.46908   11.90873  1.000 57.73684  ? 177 ASP A O   1 
ATOM   1386 C  CB  . ASP A 1 178 ? 21.06373  -0.18896  12.40271  1.000 51.89626  ? 177 ASP A CB  1 
ATOM   1387 C  CG  . ASP A 1 178 ? 21.23102  -0.92872  11.08856  1.000 55.99490  ? 177 ASP A CG  1 
ATOM   1388 O  OD1 . ASP A 1 178 ? 22.36700  -1.00882  10.57623  1.000 61.20507  ? 177 ASP A OD1 1 
ATOM   1389 O  OD2 . ASP A 1 178 ? 20.21660  -1.43702  10.56307  1.000 55.66503  ? 177 ASP A OD2 1 
ATOM   1390 N  N   . ARG A 1 179 ? 24.20090  1.43728   11.79744  1.000 56.05667  ? 178 ARG A N   1 
ATOM   1391 C  CA  . ARG A 1 179 ? 24.84685  2.53736   11.09212  1.000 59.49853  ? 178 ARG A CA  1 
ATOM   1392 C  C   . ARG A 1 179 ? 24.20225  2.81898   9.74207   1.000 59.30389  ? 178 ARG A C   1 
ATOM   1393 O  O   . ARG A 1 179 ? 24.44229  3.88592   9.16557   1.000 49.94007  ? 178 ARG A O   1 
ATOM   1394 C  CB  . ARG A 1 179 ? 26.33527  2.23041   10.91917  1.000 60.08273  ? 178 ARG A CB  1 
ATOM   1395 C  CG  . ARG A 1 179 ? 27.01015  1.69376   12.18481  1.000 64.39001  ? 178 ARG A CG  1 
ATOM   1396 C  CD  . ARG A 1 179 ? 26.99314  2.70950   13.32713  1.000 75.98273  ? 178 ARG A CD  1 
ATOM   1397 N  NE  . ARG A 1 179 ? 28.13888  2.54823   14.21704  1.000 76.95437  ? 178 ARG A NE  1 
ATOM   1398 C  CZ  . ARG A 1 179 ? 28.08224  2.05099   15.44632  1.000 88.61572  ? 178 ARG A CZ  1 
ATOM   1399 N  NH1 . ARG A 1 179 ? 26.93654  1.67990   15.99231  1.000 83.94367  ? 178 ARG A NH1 1 
ATOM   1400 N  NH2 . ARG A 1 179 ? 29.20498  1.92713   16.14837  1.000 91.62459  ? 178 ARG A NH2 1 
ATOM   1401 N  N   . ARG A 1 180 ? 23.38765  1.89544   9.23042   1.000 55.03075  ? 179 ARG A N   1 
ATOM   1402 C  CA  . ARG A 1 180 ? 22.64291  2.16636   8.00881   1.000 60.13907  ? 179 ARG A CA  1 
ATOM   1403 C  C   . ARG A 1 180 ? 21.62015  3.28189   8.21559   1.000 56.73581  ? 179 ARG A C   1 
ATOM   1404 O  O   . ARG A 1 180 ? 21.34416  4.04905   7.28199   1.000 50.61269  ? 179 ARG A O   1 
ATOM   1405 C  CB  . ARG A 1 180 ? 21.96710  0.88248   7.52642   1.000 54.52740  ? 179 ARG A CB  1 
ATOM   1406 C  CG  . ARG A 1 180 ? 22.94686  -0.25524  7.23461   1.000 56.35702  ? 179 ARG A CG  1 
ATOM   1407 C  CD  . ARG A 1 180 ? 22.20601  -1.50274  6.79133   1.000 52.82746  ? 179 ARG A CD  1 
ATOM   1408 N  NE  . ARG A 1 180 ? 21.12113  -1.81924  7.71110   1.000 61.68114  ? 179 ARG A NE  1 
ATOM   1409 C  CZ  . ARG A 1 180 ? 20.36549  -2.90650  7.64229   1.000 56.40676  ? 179 ARG A CZ  1 
ATOM   1410 N  NH1 . ARG A 1 180 ? 20.54712  -3.81893  6.70035   1.000 51.93241  ? 179 ARG A NH1 1 
ATOM   1411 N  NH2 . ARG A 1 180 ? 19.40224  -3.08303  8.54155   1.000 53.20861  ? 179 ARG A NH2 1 
ATOM   1412 N  N   . GLN A 1 181 ? 21.05911  3.39933   9.42781   1.000 52.30663  ? 180 GLN A N   1 
ATOM   1413 C  CA  . GLN A 1 181 ? 20.18619  4.53317   9.72652   1.000 53.92941  ? 180 GLN A CA  1 
ATOM   1414 C  C   . GLN A 1 181 ? 20.96319  5.84301   9.64045   1.000 52.20780  ? 180 GLN A C   1 
ATOM   1415 O  O   . GLN A 1 181 ? 20.47603  6.83597   9.08371   1.000 51.66260  ? 180 GLN A O   1 
ATOM   1416 C  CB  . GLN A 1 181 ? 19.55191  4.36208   11.11105  1.000 50.06256  ? 180 GLN A CB  1 
ATOM   1417 C  CG  . GLN A 1 181 ? 18.28589  5.19376   11.36094  1.000 50.49141  ? 180 GLN A CG  1 
ATOM   1418 C  CD  . GLN A 1 181 ? 17.69401  4.98995   12.75513  1.000 53.99327  ? 180 GLN A CD  1 
ATOM   1419 O  OE1 . GLN A 1 181 ? 18.25665  4.27964   13.58738  1.000 65.06155  ? 180 GLN A OE1 1 
ATOM   1420 N  NE2 . GLN A 1 181 ? 16.55180  5.62046   13.01017  1.000 63.24685  ? 180 GLN A NE2 1 
ATOM   1421 N  N   . ALA A 1 182 ? 22.19262  5.85179   10.16053  1.000 53.02301  ? 181 ALA A N   1 
ATOM   1422 C  CA  . ALA A 1 182 ? 23.03817  7.03491   10.05392  1.000 49.72539  ? 181 ALA A CA  1 
ATOM   1423 C  C   . ALA A 1 182 ? 23.39783  7.32479   8.60463   1.000 48.75951  ? 181 ALA A C   1 
ATOM   1424 O  O   . ALA A 1 182 ? 23.52648  8.48831   8.21649   1.000 54.81420  ? 181 ALA A O   1 
ATOM   1425 C  CB  . ALA A 1 182 ? 24.30017  6.85678   10.89554  1.000 50.70594  ? 181 ALA A CB  1 
ATOM   1426 N  N   . HIS A 1 183 ? 23.57456  6.27853   7.79480   1.000 52.35304  ? 182 HIS A N   1 
ATOM   1427 C  CA  . HIS A 1 183 ? 23.84625  6.47046   6.37297   1.000 49.72653  ? 182 HIS A CA  1 
ATOM   1428 C  C   . HIS A 1 183 ? 22.65860  7.12650   5.67292   1.000 46.59392  ? 182 HIS A C   1 
ATOM   1429 O  O   . HIS A 1 183 ? 22.82937  8.06686   4.88275   1.000 48.28507  ? 182 HIS A O   1 
ATOM   1430 C  CB  . HIS A 1 183 ? 24.19499  5.12483   5.72933   1.000 55.52911  ? 182 HIS A CB  1 
ATOM   1431 C  CG  . HIS A 1 183 ? 25.44605  4.50240   6.27303   1.000 58.28585  ? 182 HIS A CG  1 
ATOM   1432 N  ND1 . HIS A 1 183 ? 26.42642  5.23558   6.90693   1.000 62.58944  ? 182 HIS A ND1 1 
ATOM   1433 C  CD2 . HIS A 1 183 ? 25.87506  3.21797   6.28168   1.000 63.44753  ? 182 HIS A CD2 1 
ATOM   1434 C  CE1 . HIS A 1 183 ? 27.40635  4.43200   7.27996   1.000 59.21017  ? 182 HIS A CE1 1 
ATOM   1435 N  NE2 . HIS A 1 183 ? 27.09619  3.20179   6.91300   1.000 64.48384  ? 182 HIS A NE2 1 
ATOM   1436 N  N   . VAL A 1 184 ? 21.44411  6.65462   5.97293   1.000 43.64208  ? 183 VAL A N   1 
ATOM   1437 C  CA  . VAL A 1 184 ? 20.23407  7.27891   5.43676   1.000 42.63509  ? 183 VAL A CA  1 
ATOM   1438 C  C   . VAL A 1 184 ? 20.18070  8.74517   5.84080   1.000 48.75502  ? 183 VAL A C   1 
ATOM   1439 O  O   . VAL A 1 184 ? 19.86742  9.62740   5.03241   1.000 49.41524  ? 183 VAL A O   1 
ATOM   1440 C  CB  . VAL A 1 184 ? 18.97752  6.52566   5.91609   1.000 48.21138  ? 183 VAL A CB  1 
ATOM   1441 C  CG1 . VAL A 1 184 ? 17.71133  7.26047   5.48304   1.000 46.77970  ? 183 VAL A CG1 1 
ATOM   1442 C  CG2 . VAL A 1 184 ? 18.96787  5.09286   5.39765   1.000 46.09061  ? 183 VAL A CG2 1 
ATOM   1443 N  N   . TYR A 1 185 ? 20.47715  9.02057   7.11038   1.000 47.05101  ? 184 TYR A N   1 
ATOM   1444 C  CA  . TYR A 1 185 ? 20.37915  10.38240  7.62300   1.000 48.18816  ? 184 TYR A CA  1 
ATOM   1445 C  C   . TYR A 1 185 ? 21.42466  11.29868  6.99976   1.000 52.83209  ? 184 TYR A C   1 
ATOM   1446 O  O   . TYR A 1 185 ? 21.12877  12.45486  6.69205   1.000 52.25082  ? 184 TYR A O   1 
ATOM   1447 C  CB  . TYR A 1 185 ? 20.49554  10.37329  9.14718   1.000 57.60790  ? 184 TYR A CB  1 
ATOM   1448 C  CG  . TYR A 1 185 ? 19.26311  9.82637   9.82136   1.000 54.19588  ? 184 TYR A CG  1 
ATOM   1449 C  CD1 . TYR A 1 185 ? 18.07744  9.66991   9.11226   1.000 55.19444  ? 184 TYR A CD1 1 
ATOM   1450 C  CD2 . TYR A 1 185 ? 19.27918  9.47197   11.16291  1.000 47.08195  ? 184 TYR A CD2 1 
ATOM   1451 C  CE1 . TYR A 1 185 ? 16.94782  9.17637   9.72045   1.000 56.94549  ? 184 TYR A CE1 1 
ATOM   1452 C  CE2 . TYR A 1 185 ? 18.14711  8.97393   11.78398  1.000 55.00715  ? 184 TYR A CE2 1 
ATOM   1453 C  CZ  . TYR A 1 185 ? 16.98384  8.82873   11.05523  1.000 56.95432  ? 184 TYR A CZ  1 
ATOM   1454 O  OH  . TYR A 1 185 ? 15.84592  8.33457   11.65428  1.000 62.82451  ? 184 TYR A OH  1 
ATOM   1455 N  N   . LEU A 1 186 ? 22.65124  10.80784  6.80950   1.000 52.73058  ? 185 LEU A N   1 
ATOM   1456 C  CA  . LEU A 1 186 ? 23.68482  11.62766  6.18160   1.000 46.98778  ? 185 LEU A CA  1 
ATOM   1457 C  C   . LEU A 1 186 ? 23.34921  11.91291  4.72177   1.000 54.80314  ? 185 LEU A C   1 
ATOM   1458 O  O   . LEU A 1 186 ? 23.52815  13.04368  4.23674   1.000 58.30338  ? 185 LEU A O   1 
ATOM   1459 C  CB  . LEU A 1 186 ? 25.04761  10.94210  6.30496   1.000 46.30546  ? 185 LEU A CB  1 
ATOM   1460 C  CG  . LEU A 1 186 ? 25.63013  10.83129  7.72114   1.000 61.56367  ? 185 LEU A CG  1 
ATOM   1461 C  CD1 . LEU A 1 186 ? 26.99086  10.14837  7.73560   1.000 59.52646  ? 185 LEU A CD1 1 
ATOM   1462 C  CD2 . LEU A 1 186 ? 25.72376  12.19773  8.37426   1.000 43.84906  ? 185 LEU A CD2 1 
ATOM   1463 N  N   . LEU A 1 187 ? 22.83894  10.90348  4.00928   1.000 47.96357  ? 186 LEU A N   1 
ATOM   1464 C  CA  . LEU A 1 187 ? 22.42950  11.12037  2.62736   1.000 58.46347  ? 186 LEU A CA  1 
ATOM   1465 C  C   . LEU A 1 187 ? 21.31509  12.15586  2.54914   1.000 49.45353  ? 186 LEU A C   1 
ATOM   1466 O  O   . LEU A 1 187 ? 21.37558  13.09648  1.74971   1.000 52.08541  ? 186 LEU A O   1 
ATOM   1467 C  CB  . LEU A 1 187 ? 21.97454  9.80417   2.00339   1.000 46.15014  ? 186 LEU A CB  1 
ATOM   1468 C  CG  . LEU A 1 187 ? 21.37846  9.95499   0.60607   1.000 59.71676  ? 186 LEU A CG  1 
ATOM   1469 C  CD1 . LEU A 1 187 ? 22.43450  10.49702  -0.34105  1.000 58.04465  ? 186 LEU A CD1 1 
ATOM   1470 C  CD2 . LEU A 1 187 ? 20.82140  8.63039   0.10389   1.000 65.56796  ? 186 LEU A CD2 1 
ATOM   1471 N  N   . ALA A 1 188 ? 20.29190  12.00827  3.39426   1.000 53.71123  ? 187 ALA A N   1 
ATOM   1472 C  CA  . ALA A 1 188 ? 19.18169  12.95253  3.38068   1.000 52.95148  ? 187 ALA A CA  1 
ATOM   1473 C  C   . ALA A 1 188 ? 19.62019  14.33852  3.82514   1.000 58.89949  ? 187 ALA A C   1 
ATOM   1474 O  O   . ALA A 1 188 ? 19.08673  15.34133  3.33944   1.000 56.03515  ? 187 ALA A O   1 
ATOM   1475 C  CB  . ALA A 1 188 ? 18.05131  12.44603  4.27283   1.000 46.93831  ? 187 ALA A CB  1 
ATOM   1476 N  N   . ALA A 1 189 ? 20.58552  14.41140  4.74276   1.000 53.45492  ? 188 ALA A N   1 
ATOM   1477 C  CA  . ALA A 1 189 ? 21.05474  15.69591  5.23990   1.000 56.26786  ? 188 ALA A CA  1 
ATOM   1478 C  C   . ALA A 1 189 ? 21.81402  16.45279  4.16496   1.000 56.25582  ? 188 ALA A C   1 
ATOM   1479 O  O   . ALA A 1 189 ? 21.74519  17.68610  4.09870   1.000 59.90322  ? 188 ALA A O   1 
ATOM   1480 C  CB  . ALA A 1 189 ? 21.93108  15.48732  6.47318   1.000 46.80454  ? 188 ALA A CB  1 
ATOM   1481 N  N   . SER A 1 190 ? 22.55356  15.72801  3.31719   1.000 54.82413  ? 189 SER A N   1 
ATOM   1482 C  CA  . SER A 1 190 ? 23.31432  16.38821  2.25920   1.000 61.27252  ? 189 SER A CA  1 
ATOM   1483 C  C   . SER A 1 190 ? 22.42505  17.22042  1.34085   1.000 61.67275  ? 189 SER A C   1 
ATOM   1484 O  O   . SER A 1 190 ? 22.89902  18.18729  0.73388   1.000 58.50438  ? 189 SER A O   1 
ATOM   1485 C  CB  . SER A 1 190 ? 24.08111  15.35531  1.44136   1.000 46.93319  ? 189 SER A CB  1 
ATOM   1486 O  OG  . SER A 1 190 ? 23.19605  14.38638  0.91097   1.000 63.13520  ? 189 SER A OG  1 
ATOM   1487 N  N   . TYR A 1 191 ? 21.14451  16.86423  1.21761   1.000 64.23423  ? 190 TYR A N   1 
ATOM   1488 C  CA  . TYR A 1 191 ? 20.23816  17.60134  0.34489   1.000 59.13358  ? 190 TYR A CA  1 
ATOM   1489 C  C   . TYR A 1 191 ? 19.58390  18.78929  1.03319   1.000 64.31764  ? 190 TYR A C   1 
ATOM   1490 O  O   . TYR A 1 191 ? 18.88145  19.55598  0.36568   1.000 68.39290  ? 190 TYR A O   1 
ATOM   1491 C  CB  . TYR A 1 191 ? 19.14824  16.67469  -0.20897  1.000 55.90698  ? 190 TYR A CB  1 
ATOM   1492 C  CG  . TYR A 1 191 ? 19.63973  15.68019  -1.23250  1.000 62.47209  ? 190 TYR A CG  1 
ATOM   1493 C  CD1 . TYR A 1 191 ? 20.59951  14.73694  -0.90141  1.000 65.13043  ? 190 TYR A CD1 1 
ATOM   1494 C  CD2 . TYR A 1 191 ? 19.13364  15.67138  -2.52321  1.000 72.62993  ? 190 TYR A CD2 1 
ATOM   1495 C  CE1 . TYR A 1 191 ? 21.05564  13.82071  -1.82817  1.000 59.78798  ? 190 TYR A CE1 1 
ATOM   1496 C  CE2 . TYR A 1 191 ? 19.58329  14.75413  -3.46052  1.000 63.06833  ? 190 TYR A CE2 1 
ATOM   1497 C  CZ  . TYR A 1 191 ? 20.54496  13.83301  -3.10811  1.000 59.31062  ? 190 TYR A CZ  1 
ATOM   1498 O  OH  . TYR A 1 191 ? 20.99118  12.92346  -4.03762  1.000 56.08511  ? 190 TYR A OH  1 
ATOM   1499 N  N   . ARG A 1 192 ? 19.78376  18.95545  2.33908   1.000 62.40742  ? 191 ARG A N   1 
ATOM   1500 C  CA  . ARG A 1 192 ? 19.26168  20.10620  3.06217   1.000 68.05339  ? 191 ARG A CA  1 
ATOM   1501 C  C   . ARG A 1 192 ? 20.34003  21.08582  3.48614   1.000 63.90198  ? 191 ARG A C   1 
ATOM   1502 O  O   . ARG A 1 192 ? 20.04162  22.26682  3.67749   1.000 64.32814  ? 191 ARG A O   1 
ATOM   1503 C  CB  . ARG A 1 192 ? 18.48659  19.65415  4.30501   1.000 64.89801  ? 191 ARG A CB  1 
ATOM   1504 C  CG  . ARG A 1 192 ? 17.20430  18.90283  3.99921   1.000 78.51369  ? 191 ARG A CG  1 
ATOM   1505 C  CD  . ARG A 1 192 ? 16.65312  18.24936  5.25337   1.000 90.64342  ? 191 ARG A CD  1 
ATOM   1506 N  NE  . ARG A 1 192 ? 16.08281  19.21652  6.18348   1.000 93.12204  ? 191 ARG A NE  1 
ATOM   1507 C  CZ  . ARG A 1 192 ? 15.58261  18.90224  7.37158   1.000 91.81881  ? 191 ARG A CZ  1 
ATOM   1508 N  NH1 . ARG A 1 192 ? 15.59300  17.65699  7.82035   1.000 94.32017  ? 191 ARG A NH1 1 
ATOM   1509 N  NH2 . ARG A 1 192 ? 15.05554  19.85978  8.12847   1.000 87.02550  ? 191 ARG A NH2 1 
ATOM   1510 N  N   . TYR A 1 193 ? 21.58030  20.62436  3.63708   1.000 58.26134  ? 192 TYR A N   1 
ATOM   1511 C  CA  . TYR A 1 193 ? 22.73647  21.49023  3.87143   1.000 61.36769  ? 192 TYR A CA  1 
ATOM   1512 C  C   . TYR A 1 193 ? 23.83479  21.09533  2.89509   1.000 57.76652  ? 192 TYR A C   1 
ATOM   1513 O  O   . TYR A 1 193 ? 24.85272  20.50901  3.28195   1.000 58.67982  ? 192 TYR A O   1 
ATOM   1514 C  CB  . TYR A 1 193 ? 23.22185  21.39850  5.31785   1.000 60.50117  ? 192 TYR A CB  1 
ATOM   1515 C  CG  . TYR A 1 193 ? 22.12879  21.62186  6.33132   1.000 66.56695  ? 192 TYR A CG  1 
ATOM   1516 C  CD1 . TYR A 1 193 ? 21.86006  22.88924  6.82259   1.000 69.72840  ? 192 TYR A CD1 1 
ATOM   1517 C  CD2 . TYR A 1 193 ? 21.36433  20.56096  6.79909   1.000 66.94302  ? 192 TYR A CD2 1 
ATOM   1518 C  CE1 . TYR A 1 193 ? 20.85715  23.09408  7.75043   1.000 71.38936  ? 192 TYR A CE1 1 
ATOM   1519 C  CE2 . TYR A 1 193 ? 20.35836  20.75670  7.72384   1.000 70.40785  ? 192 TYR A CE2 1 
ATOM   1520 C  CZ  . TYR A 1 193 ? 20.10885  22.02426  8.19758   1.000 69.43138  ? 192 TYR A CZ  1 
ATOM   1521 O  OH  . TYR A 1 193 ? 19.10697  22.22058  9.11663   1.000 67.92950  ? 192 TYR A OH  1 
ATOM   1522 N  N   . PRO A 1 194 ? 23.65434  21.40419  1.60984   1.000 59.99078  ? 193 PRO A N   1 
ATOM   1523 C  CA  . PRO A 1 194 ? 24.57656  20.88659  0.58452   1.000 58.60520  ? 193 PRO A CA  1 
ATOM   1524 C  C   . PRO A 1 194 ? 26.01453  21.34927  0.73778   1.000 62.05358  ? 193 PRO A C   1 
ATOM   1525 O  O   . PRO A 1 194 ? 26.93171  20.63703  0.30853   1.000 60.14484  ? 193 PRO A O   1 
ATOM   1526 C  CB  . PRO A 1 194 ? 23.96517  21.40751  -0.72234  1.000 60.50125  ? 193 PRO A CB  1 
ATOM   1527 C  CG  . PRO A 1 194 ? 22.53862  21.74685  -0.38502  1.000 60.50294  ? 193 PRO A CG  1 
ATOM   1528 C  CD  . PRO A 1 194 ? 22.57247  22.21508  1.02883   1.000 60.50832  ? 193 PRO A CD  1 
ATOM   1529 N  N   . GLN A 1 195 ? 26.24250  22.52428  1.31799   1.000 67.06562  ? 194 GLN A N   1 
ATOM   1530 C  CA  . GLN A 1 195 ? 27.57236  23.11026  1.38626   1.000 65.80044  ? 194 GLN A CA  1 
ATOM   1531 C  C   . GLN A 1 195 ? 28.29947  22.80520  2.68893   1.000 70.73834  ? 194 GLN A C   1 
ATOM   1532 O  O   . GLN A 1 195 ? 29.45249  23.21782  2.84636   1.000 71.69789  ? 194 GLN A O   1 
ATOM   1533 C  CB  . GLN A 1 195 ? 27.48731  24.62867  1.19961   1.000 63.07236  ? 194 GLN A CB  1 
ATOM   1534 C  CG  . GLN A 1 195 ? 27.52424  25.10684  -0.24871  1.000 64.15494  ? 194 GLN A CG  1 
ATOM   1535 C  CD  . GLN A 1 195 ? 26.22984  24.85481  -0.99452  1.000 66.48464  ? 194 GLN A CD  1 
ATOM   1536 O  OE1 . GLN A 1 195 ? 25.14694  25.21068  -0.52679  1.000 71.61441  ? 194 GLN A OE1 1 
ATOM   1537 N  NE2 . GLN A 1 195 ? 26.33654  24.23701  -2.16526  1.000 61.66721  ? 194 GLN A NE2 1 
ATOM   1538 N  N   . GLU A 1 196 ? 27.67345  22.09061  3.61800   1.000 69.56486  ? 195 GLU A N   1 
ATOM   1539 C  CA  . GLU A 1 196 ? 28.21294  21.94902  4.96041   1.000 68.16674  ? 195 GLU A CA  1 
ATOM   1540 C  C   . GLU A 1 196 ? 28.70530  20.52997  5.21157   1.000 71.70225  ? 195 GLU A C   1 
ATOM   1541 O  O   . GLU A 1 196 ? 28.27122  19.57090  4.57032   1.000 70.13026  ? 195 GLU A O   1 
ATOM   1542 C  CB  . GLU A 1 196 ? 27.15996  22.33035  6.00448   1.000 69.57159  ? 195 GLU A CB  1 
ATOM   1543 C  CG  . GLU A 1 196 ? 26.56113  23.71253  5.80602   1.000 72.86987  ? 195 GLU A CG  1 
ATOM   1544 C  CD  . GLU A 1 196 ? 26.80419  24.63714  6.98329   1.000 84.47838  ? 195 GLU A CD  1 
ATOM   1545 O  OE1 . GLU A 1 196 ? 27.98235  24.87953  7.32298   1.000 90.51405  ? 195 GLU A OE1 1 
ATOM   1546 O  OE2 . GLU A 1 196 ? 25.81243  25.11848  7.57291   1.000 88.71595  ? 195 GLU A OE2 1 
ATOM   1547 N  N   . LYS A 1 197 ? 29.63195  20.41675  6.16013   1.000 73.53373  ? 196 LYS A N   1 
ATOM   1548 C  CA  . LYS A 1 197 ? 30.11383  19.12106  6.61675   1.000 69.76562  ? 196 LYS A CA  1 
ATOM   1549 C  C   . LYS A 1 197 ? 29.11298  18.53914  7.60566   1.000 71.30451  ? 196 LYS A C   1 
ATOM   1550 O  O   . LYS A 1 197 ? 28.63650  19.24104  8.50156   1.000 72.79336  ? 196 LYS A O   1 
ATOM   1551 C  CB  . LYS A 1 197 ? 31.49283  19.25676  7.26300   1.000 69.54724  ? 196 LYS A CB  1 
ATOM   1552 C  CG  . LYS A 1 197 ? 32.47675  20.10783  6.46493   1.000 82.58225  ? 196 LYS A CG  1 
ATOM   1553 C  CD  . LYS A 1 197 ? 32.59140  19.65999  5.00630   1.000 84.43857  ? 196 LYS A CD  1 
ATOM   1554 C  CE  . LYS A 1 197 ? 33.18507  18.26351  4.87437   1.000 89.55977  ? 196 LYS A CE  1 
ATOM   1555 N  NZ  . LYS A 1 197 ? 33.34504  17.87604  3.44347   1.000 87.43084  ? 196 LYS A NZ  1 
ATOM   1556 N  N   . ILE A 1 198 ? 28.78006  17.26241  7.43617   1.000 68.62573  ? 197 ILE A N   1 
ATOM   1557 C  CA  . ILE A 1 198 ? 27.67259  16.64192  8.15437   1.000 61.07624  ? 197 ILE A CA  1 
ATOM   1558 C  C   . ILE A 1 198 ? 28.16114  15.36819  8.83477   1.000 62.73992  ? 197 ILE A C   1 
ATOM   1559 O  O   . ILE A 1 198 ? 28.87239  14.56340  8.22341   1.000 64.63134  ? 197 ILE A O   1 
ATOM   1560 C  CB  . ILE A 1 198 ? 26.49181  16.34132  7.21021   1.000 61.39958  ? 197 ILE A CB  1 
ATOM   1561 C  CG1 . ILE A 1 198 ? 26.08118  17.61385  6.45448   1.000 63.03751  ? 197 ILE A CG1 1 
ATOM   1562 C  CG2 . ILE A 1 198 ? 25.31374  15.78930  7.98363   1.000 55.78796  ? 197 ILE A CG2 1 
ATOM   1563 C  CD1 . ILE A 1 198 ? 24.88656  17.42772  5.54666   1.000 58.64831  ? 197 ILE A CD1 1 
ATOM   1564 N  N   . VAL A 1 199 ? 27.78416  15.18946  10.10213  1.000 63.19094  ? 198 VAL A N   1 
ATOM   1565 C  CA  . VAL A 1 199 ? 28.10343  13.98574  10.85582  1.000 58.18866  ? 198 VAL A CA  1 
ATOM   1566 C  C   . VAL A 1 199 ? 26.83646  13.50312  11.54901  1.000 57.78127  ? 198 VAL A C   1 
ATOM   1567 O  O   . VAL A 1 199 ? 25.86666  14.24640  11.71418  1.000 53.55574  ? 198 VAL A O   1 
ATOM   1568 C  CB  . VAL A 1 199 ? 29.23159  14.21420  11.88818  1.000 58.53885  ? 198 VAL A CB  1 
ATOM   1569 C  CG1 . VAL A 1 199 ? 30.53934  14.55498  11.19336  1.000 48.02125  ? 198 VAL A CG1 1 
ATOM   1570 C  CG2 . VAL A 1 199 ? 28.84769  15.32070  12.85923  1.000 64.10260  ? 198 VAL A CG2 1 
ATOM   1571 N  N   . ALA A 1 200 ? 26.85285  12.23565  11.95323  1.000 47.15351  ? 199 ALA A N   1 
ATOM   1572 C  CA  . ALA A 1 200 ? 25.72114  11.64202  12.64639  1.000 54.69840  ? 199 ALA A CA  1 
ATOM   1573 C  C   . ALA A 1 200 ? 26.22206  10.83455  13.83186  1.000 54.98941  ? 199 ALA A C   1 
ATOM   1574 O  O   . ALA A 1 200 ? 27.34661  10.32914  13.83117  1.000 54.51263  ? 199 ALA A O   1 
ATOM   1575 C  CB  . ALA A 1 200 ? 24.88164  10.74941  11.71853  1.000 58.71332  ? 199 ALA A CB  1 
ATOM   1576 N  N   . SER A 1 201 ? 25.37341  10.72735  14.84881  1.000 52.55262  ? 200 SER A N   1 
ATOM   1577 C  CA  . SER A 1 201 ? 25.69786  9.95232   16.03378  1.000 57.93232  ? 200 SER A CA  1 
ATOM   1578 C  C   . SER A 1 201 ? 24.40647  9.45653   16.66191  1.000 58.72008  ? 200 SER A C   1 
ATOM   1579 O  O   . SER A 1 201 ? 23.32065  9.98430   16.40419  1.000 60.38465  ? 200 SER A O   1 
ATOM   1580 C  CB  . SER A 1 201 ? 26.50278  10.77007  17.05272  1.000 52.02842  ? 200 SER A CB  1 
ATOM   1581 O  OG  . SER A 1 201 ? 25.64968  11.56246  17.86301  1.000 45.88319  ? 200 SER A OG  1 
ATOM   1582 N  N   . PHE A 1 202 ? 24.53990  8.42392   17.48349  1.000 54.35563  ? 201 PHE A N   1 
ATOM   1583 C  CA  . PHE A 1 202 ? 23.44260  7.90074   18.27692  1.000 57.93767  ? 201 PHE A CA  1 
ATOM   1584 C  C   . PHE A 1 202 ? 23.64033  8.27555   19.73825  1.000 59.52343  ? 201 PHE A C   1 
ATOM   1585 O  O   . PHE A 1 202 ? 24.76341  8.49754   20.19873  1.000 61.89740  ? 201 PHE A O   1 
ATOM   1586 C  CB  . PHE A 1 202 ? 23.34313  6.37992   18.14220  1.000 58.71870  ? 201 PHE A CB  1 
ATOM   1587 C  CG  . PHE A 1 202 ? 22.98824  5.91606   16.76425  1.000 61.28421  ? 201 PHE A CG  1 
ATOM   1588 C  CD1 . PHE A 1 202 ? 23.97417  5.64542   15.83234  1.000 55.47267  ? 201 PHE A CD1 1 
ATOM   1589 C  CD2 . PHE A 1 202 ? 21.66597  5.74458   16.40130  1.000 62.71507  ? 201 PHE A CD2 1 
ATOM   1590 C  CE1 . PHE A 1 202 ? 23.64339  5.21489   14.56143  1.000 57.12416  ? 201 PHE A CE1 1 
ATOM   1591 C  CE2 . PHE A 1 202 ? 21.33266  5.31529   15.13541  1.000 50.32024  ? 201 PHE A CE2 1 
ATOM   1592 C  CZ  . PHE A 1 202 ? 22.32131  5.04970   14.21486  1.000 60.09657  ? 201 PHE A CZ  1 
ATOM   1593 N  N   . TYR A 1 203 ? 22.52902  8.35321   20.46511  1.000 60.99347  ? 202 TYR A N   1 
ATOM   1594 C  CA  . TYR A 1 203 ? 22.58152  8.52829   21.91138  1.000 60.67298  ? 202 TYR A CA  1 
ATOM   1595 C  C   . TYR A 1 203 ? 21.38476  7.81736   22.51675  1.000 62.73472  ? 202 TYR A C   1 
ATOM   1596 O  O   . TYR A 1 203 ? 20.24235  8.12313   22.16655  1.000 58.81842  ? 202 TYR A O   1 
ATOM   1597 C  CB  . TYR A 1 203 ? 22.58537  10.00608  22.30840  1.000 66.04059  ? 202 TYR A CB  1 
ATOM   1598 C  CG  . TYR A 1 203 ? 22.86648  10.20941  23.77562  1.000 62.81544  ? 202 TYR A CG  1 
ATOM   1599 C  CD1 . TYR A 1 203 ? 24.16537  10.18452  24.25670  1.000 59.37378  ? 202 TYR A CD1 1 
ATOM   1600 C  CD2 . TYR A 1 203 ? 21.83628  10.40792  24.68139  1.000 64.07606  ? 202 TYR A CD2 1 
ATOM   1601 C  CE1 . TYR A 1 203 ? 24.43435  10.35757  25.59706  1.000 67.05731  ? 202 TYR A CE1 1 
ATOM   1602 C  CE2 . TYR A 1 203 ? 22.09598  10.58717  26.02748  1.000 67.40521  ? 202 TYR A CE2 1 
ATOM   1603 C  CZ  . TYR A 1 203 ? 23.39776  10.55942  26.47989  1.000 64.78315  ? 202 TYR A CZ  1 
ATOM   1604 O  OH  . TYR A 1 203 ? 23.66382  10.73385  27.81558  1.000 59.74108  ? 202 TYR A OH  1 
ATOM   1605 N  N   . ASN A 1 204 ? 21.64493  6.86292   23.40310  1.000 65.07107  ? 203 ASN A N   1 
ATOM   1606 C  CA  . ASN A 1 204 ? 20.57802  6.21255   24.14925  1.000 67.26741  ? 203 ASN A CA  1 
ATOM   1607 C  C   . ASN A 1 204 ? 20.29784  7.02763   25.40657  1.000 68.66140  ? 203 ASN A C   1 
ATOM   1608 O  O   . ASN A 1 204 ? 21.20166  7.25968   26.21756  1.000 68.54447  ? 203 ASN A O   1 
ATOM   1609 C  CB  . ASN A 1 204 ? 20.96583  4.77757   24.49781  1.000 67.18052  ? 203 ASN A CB  1 
ATOM   1610 C  CG  . ASN A 1 204 ? 19.79400  3.96424   25.02489  1.000 69.35751  ? 203 ASN A CG  1 
ATOM   1611 O  OD1 . ASN A 1 204 ? 19.25192  4.25618   26.09538  1.000 64.94501  ? 203 ASN A OD1 1 
ATOM   1612 N  ND2 . ASN A 1 204 ? 19.41106  2.92406   24.28487  1.000 74.90924  ? 203 ASN A ND2 1 
ATOM   1613 N  N   . LEU A 1 205 ? 19.05105  7.47622   25.56265  1.000 67.48760  ? 204 LEU A N   1 
ATOM   1614 C  CA  . LEU A 1 205 ? 18.70242  8.29208   26.71904  1.000 66.30540  ? 204 LEU A CA  1 
ATOM   1615 C  C   . LEU A 1 205 ? 18.53815  7.46321   27.98834  1.000 71.16312  ? 204 LEU A C   1 
ATOM   1616 O  O   . LEU A 1 205 ? 18.59460  8.02200   29.09087  1.000 72.20858  ? 204 LEU A O   1 
ATOM   1617 C  CB  . LEU A 1 205 ? 17.42336  9.07396   26.43707  1.000 61.09066  ? 204 LEU A CB  1 
ATOM   1618 C  CG  . LEU A 1 205 ? 17.47055  10.11801  25.32150  1.000 66.26254  ? 204 LEU A CG  1 
ATOM   1619 C  CD1 . LEU A 1 205 ? 16.08665  10.70127  25.10874  1.000 65.58278  ? 204 LEU A CD1 1 
ATOM   1620 C  CD2 . LEU A 1 205 ? 18.47536  11.21874  25.64030  1.000 67.01473  ? 204 LEU A CD2 1 
ATOM   1621 N  N   . GLU A 1 206 ? 18.35462  6.14570   27.85861  1.000 76.70416  ? 205 GLU A N   1 
ATOM   1622 C  CA  . GLU A 1 206 ? 18.16871  5.26640   29.00407  1.000 68.37545  ? 205 GLU A CA  1 
ATOM   1623 C  C   . GLU A 1 206 ? 19.46939  4.64692   29.49278  1.000 68.37890  ? 205 GLU A C   1 
ATOM   1624 O  O   . GLU A 1 206 ? 19.57848  4.33166   30.68235  1.000 75.28712  ? 205 GLU A O   1 
ATOM   1625 C  CB  . GLU A 1 206 ? 17.17694  4.14972   28.65280  1.000 76.12176  ? 205 GLU A CB  1 
ATOM   1626 C  CG  . GLU A 1 206 ? 16.73883  3.30408   29.83827  1.000 77.05091  ? 205 GLU A CG  1 
ATOM   1627 C  CD  . GLU A 1 206 ? 16.00797  2.04437   29.42347  1.000 81.60737  ? 205 GLU A CD  1 
ATOM   1628 O  OE1 . GLU A 1 206 ? 15.03964  2.14117   28.63866  1.000 81.42153  ? 205 GLU A OE1 1 
ATOM   1629 O  OE2 . GLU A 1 206 ? 16.40859  0.95182   29.87750  1.000 83.16510  ? 205 GLU A OE2 1 
ATOM   1630 N  N   . THR A 1 207 ? 20.45202  4.46483   28.61167  1.000 67.76417  ? 206 THR A N   1 
ATOM   1631 C  CA  . THR A 1 207 ? 21.77340  4.01436   29.01771  1.000 64.35130  ? 206 THR A CA  1 
ATOM   1632 C  C   . THR A 1 207 ? 22.76190  5.16196   29.15718  1.000 64.66008  ? 206 THR A C   1 
ATOM   1633 O  O   . THR A 1 207 ? 23.86760  4.94758   29.66337  1.000 62.92118  ? 206 THR A O   1 
ATOM   1634 C  CB  . THR A 1 207 ? 22.31955  2.99075   28.01500  1.000 64.90380  ? 206 THR A CB  1 
ATOM   1635 O  OG1 . THR A 1 207 ? 22.69757  3.65728   26.80523  1.000 65.02153  ? 206 THR A OG1 1 
ATOM   1636 C  CG2 . THR A 1 207 ? 21.26300  1.94359   27.69227  1.000 62.51808  ? 206 THR A CG2 1 
ATOM   1637 N  N   . GLN A 1 208 ? 22.38043  6.37029   28.74006  1.000 71.22082  ? 207 GLN A N   1 
ATOM   1638 C  CA  . GLN A 1 208 ? 23.27919  7.52373   28.72299  1.000 68.46393  ? 207 GLN A CA  1 
ATOM   1639 C  C   . GLN A 1 208 ? 24.57694  7.18587   27.98844  1.000 66.66678  ? 207 GLN A C   1 
ATOM   1640 O  O   . GLN A 1 208 ? 25.66759  7.62357   28.36132  1.000 71.31631  ? 207 GLN A O   1 
ATOM   1641 C  CB  . GLN A 1 208 ? 23.54002  8.03533   30.14438  1.000 62.00210  ? 207 GLN A CB  1 
ATOM   1642 C  CG  . GLN A 1 208 ? 22.27934  8.54906   30.84193  1.000 66.34595  ? 207 GLN A CG  1 
ATOM   1643 C  CD  . GLN A 1 208 ? 22.55114  9.13153   32.21422  1.000 68.29562  ? 207 GLN A CD  1 
ATOM   1644 O  OE1 . GLN A 1 208 ? 22.35470  10.32543  32.44172  1.000 72.09361  ? 207 GLN A OE1 1 
ATOM   1645 N  NE2 . GLN A 1 208 ? 22.99519  8.28860   33.14057  1.000 67.88400  ? 207 GLN A NE2 1 
ATOM   1646 N  N   . THR A 1 209 ? 24.44369  6.40924   26.91571  1.000 64.81469  ? 208 THR A N   1 
ATOM   1647 C  CA  . THR A 1 209 ? 25.55653  5.97997   26.08251  1.000 69.39774  ? 208 THR A CA  1 
ATOM   1648 C  C   . THR A 1 209 ? 25.42344  6.60954   24.70077  1.000 63.62579  ? 208 THR A C   1 
ATOM   1649 O  O   . THR A 1 209 ? 24.31614  6.72352   24.16403  1.000 70.31668  ? 208 THR A O   1 
ATOM   1650 C  CB  . THR A 1 209 ? 25.59013  4.45120   25.96955  1.000 59.39461  ? 208 THR A CB  1 
ATOM   1651 O  OG1 . THR A 1 209 ? 25.64893  3.87957   27.28169  1.000 67.41118  ? 208 THR A OG1 1 
ATOM   1652 C  CG2 . THR A 1 209 ? 26.79215  3.98330   25.16100  1.000 62.90920  ? 208 THR A CG2 1 
ATOM   1653 N  N   . SER A 1 210 ? 26.55206  7.02487   24.13038  1.000 69.56607  ? 209 SER A N   1 
ATOM   1654 C  CA  . SER A 1 210 ? 26.58278  7.66044   22.82216  1.000 63.01509  ? 209 SER A CA  1 
ATOM   1655 C  C   . SER A 1 210 ? 27.42755  6.83367   21.86127  1.000 66.51274  ? 209 SER A C   1 
ATOM   1656 O  O   . SER A 1 210 ? 28.34126  6.11209   22.27418  1.000 66.95976  ? 209 SER A O   1 
ATOM   1657 C  CB  . SER A 1 210 ? 27.14793  9.08491   22.90612  1.000 64.69549  ? 209 SER A CB  1 
ATOM   1658 O  OG  . SER A 1 210 ? 28.56104  9.06836   23.03920  1.000 67.45226  ? 209 SER A OG  1 
ATOM   1659 N  N   . SER A 1 211 ? 27.10844  6.93979   20.57346  1.000 67.61538  ? 210 SER A N   1 
ATOM   1660 C  CA  . SER A 1 211 ? 27.92607  6.34147   19.53188  1.000 61.08021  ? 210 SER A CA  1 
ATOM   1661 C  C   . SER A 1 211 ? 29.07139  7.28033   19.16188  1.000 64.54396  ? 210 SER A C   1 
ATOM   1662 O  O   . SER A 1 211 ? 29.11555  8.44511   19.56593  1.000 70.89473  ? 210 SER A O   1 
ATOM   1663 C  CB  . SER A 1 211 ? 27.08640  6.03255   18.29294  1.000 59.89562  ? 210 SER A CB  1 
ATOM   1664 O  OG  . SER A 1 211 ? 26.87731  7.20858   17.52793  1.000 60.70010  ? 210 SER A OG  1 
ATOM   1665 N  N   . GLU A 1 212 ? 30.01505  6.75752   18.38580  1.000 65.17385  ? 211 GLU A N   1 
ATOM   1666 C  CA  . GLU A 1 212 ? 31.03818  7.60409   17.79606  1.000 68.07184  ? 211 GLU A CA  1 
ATOM   1667 C  C   . GLU A 1 212 ? 30.42424  8.43646   16.67495  1.000 69.94369  ? 211 GLU A C   1 
ATOM   1668 O  O   . GLU A 1 212 ? 29.23468  8.33711   16.36471  1.000 66.48315  ? 211 GLU A O   1 
ATOM   1669 C  CB  . GLU A 1 212 ? 32.20430  6.76451   17.27836  1.000 77.02405  ? 211 GLU A CB  1 
ATOM   1670 C  CG  . GLU A 1 212 ? 31.87869  5.92344   16.05396  1.000 81.54965  ? 211 GLU A CG  1 
ATOM   1671 C  CD  . GLU A 1 212 ? 30.99740  4.72837   16.37125  1.000 92.08852  ? 211 GLU A CD  1 
ATOM   1672 O  OE1 . GLU A 1 212 ? 31.27047  4.03726   17.37355  1.000 80.79199  ? 211 GLU A OE1 1 
ATOM   1673 O  OE2 . GLU A 1 212 ? 30.02978  4.47675   15.62194  1.000 87.53606  ? 211 GLU A OE2 1 
ATOM   1674 N  N   . LYS A 1 213 ? 31.24940  9.26451   16.04954  1.000 67.74774  ? 212 LYS A N   1 
ATOM   1675 C  CA  . LYS A 1 213 ? 30.77391  10.16365  15.01064  1.000 66.55499  ? 212 LYS A CA  1 
ATOM   1676 C  C   . LYS A 1 213 ? 30.93194  9.50856   13.64769  1.000 66.34716  ? 212 LYS A C   1 
ATOM   1677 O  O   . LYS A 1 213 ? 32.01146  9.01630   13.30870  1.000 66.53238  ? 212 LYS A O   1 
ATOM   1678 C  CB  . LYS A 1 213 ? 31.52386  11.49413  15.06770  1.000 77.75226  ? 212 LYS A CB  1 
ATOM   1679 C  CG  . LYS A 1 213 ? 30.95895  12.47261  16.08743  1.000 76.98234  ? 212 LYS A CG  1 
ATOM   1680 C  CD  . LYS A 1 213 ? 32.07137  13.25415  16.76210  1.000 84.60678  ? 212 LYS A CD  1 
ATOM   1681 C  CE  . LYS A 1 213 ? 32.73686  12.43948  17.85566  1.000 77.41061  ? 212 LYS A CE  1 
ATOM   1682 N  NZ  . LYS A 1 213 ? 31.82071  12.24166  19.00222  1.000 67.48696  ? 212 LYS A NZ  1 
ATOM   1683 N  N   . ILE A 1 214 ? 29.85246  9.51087   12.87191  1.000 63.15980  ? 213 ILE A N   1 
ATOM   1684 C  CA  . ILE A 1 214 ? 29.79503  8.83212   11.58483  1.000 60.91972  ? 213 ILE A CA  1 
ATOM   1685 C  C   . ILE A 1 214 ? 29.72382  9.87769   10.48272  1.000 62.41573  ? 213 ILE A C   1 
ATOM   1686 O  O   . ILE A 1 214 ? 28.84517  10.74712  10.49955  1.000 70.35196  ? 213 ILE A O   1 
ATOM   1687 C  CB  . ILE A 1 214 ? 28.59003  7.88063   11.51030  1.000 63.64453  ? 213 ILE A CB  1 
ATOM   1688 C  CG1 . ILE A 1 214 ? 28.45941  7.08883   12.81065  1.000 65.33657  ? 213 ILE A CG1 1 
ATOM   1689 C  CG2 . ILE A 1 214 ? 28.73642  6.93565   10.33325  1.000 57.50342  ? 213 ILE A CG2 1 
ATOM   1690 C  CD1 . ILE A 1 214 ? 27.20995  6.25609   12.88357  1.000 62.81863  ? 213 ILE A CD1 1 
ATOM   1691 N  N   . SER A 1 215 ? 30.64232  9.78956   9.52511   1.000 64.81917  ? 214 SER A N   1 
ATOM   1692 C  CA  . SER A 1 215 ? 30.63433  10.62402  8.33301   1.000 61.54622  ? 214 SER A CA  1 
ATOM   1693 C  C   . SER A 1 215 ? 30.74311  9.72741   7.10799   1.000 63.96798  ? 214 SER A C   1 
ATOM   1694 O  O   . SER A 1 215 ? 31.06235  8.54109   7.20988   1.000 64.93727  ? 214 SER A O   1 
ATOM   1695 C  CB  . SER A 1 215 ? 31.77611  11.64850  8.36054   1.000 65.90376  ? 214 SER A CB  1 
ATOM   1696 O  OG  . SER A 1 215 ? 33.02741  11.00669  8.52408   1.000 85.71844  ? 214 SER A OG  1 
ATOM   1697 N  N   . LEU A 1 216 ? 30.47251  10.30238  5.93781   1.000 62.32231  ? 215 LEU A N   1 
ATOM   1698 C  CA  . LEU A 1 216 ? 30.50998  9.55621   4.68461   1.000 62.07461  ? 215 LEU A CA  1 
ATOM   1699 C  C   . LEU A 1 216 ? 31.26206  10.36896  3.64573   1.000 63.08342  ? 215 LEU A C   1 
ATOM   1700 O  O   . LEU A 1 216 ? 30.90938  11.52361  3.38737   1.000 70.21988  ? 215 LEU A O   1 
ATOM   1701 C  CB  . LEU A 1 216 ? 29.09904  9.23383   4.17821   1.000 60.89715  ? 215 LEU A CB  1 
ATOM   1702 C  CG  . LEU A 1 216 ? 28.25708  8.21756   4.95112   1.000 61.50512  ? 215 LEU A CG  1 
ATOM   1703 C  CD1 . LEU A 1 216 ? 26.89831  8.03938   4.28319   1.000 51.22268  ? 215 LEU A CD1 1 
ATOM   1704 C  CD2 . LEU A 1 216 ? 28.98794  6.88994   5.06914   1.000 65.44586  ? 215 LEU A CD2 1 
ATOM   1705 N  N   . SER A 1 217 ? 32.29173  9.76913   3.05410   1.000 65.88060  ? 216 SER A N   1 
ATOM   1706 C  CA  . SER A 1 217 ? 32.90494  10.35077  1.87383   1.000 68.90094  ? 216 SER A CA  1 
ATOM   1707 C  C   . SER A 1 217 ? 31.93036  10.28010  0.70045   1.000 67.16793  ? 216 SER A C   1 
ATOM   1708 O  O   . SER A 1 217 ? 30.90255  9.60008   0.75056   1.000 62.37384  ? 216 SER A O   1 
ATOM   1709 C  CB  . SER A 1 217 ? 34.20883  9.63142   1.53275   1.000 66.82488  ? 216 SER A CB  1 
ATOM   1710 O  OG  . SER A 1 217 ? 34.00137  8.23795   1.37666   1.000 77.99076  ? 216 SER A OG  1 
ATOM   1711 N  N   . SER A 1 218 ? 32.26015  11.00499  -0.36978  1.000 71.50858  ? 217 SER A N   1 
ATOM   1712 C  CA  . SER A 1 218 ? 31.38154  11.03218  -1.53611  1.000 71.74177  ? 217 SER A CA  1 
ATOM   1713 C  C   . SER A 1 218 ? 31.23749  9.64295   -2.14761  1.000 73.10076  ? 217 SER A C   1 
ATOM   1714 O  O   . SER A 1 218 ? 30.15024  9.26502   -2.61249  1.000 73.08735  ? 217 SER A O   1 
ATOM   1715 C  CB  . SER A 1 218 ? 31.90962  12.03149  -2.56696  1.000 77.04129  ? 217 SER A CB  1 
ATOM   1716 O  OG  . SER A 1 218 ? 33.30210  11.87151  -2.76491  1.000 79.96566  ? 217 SER A OG  1 
ATOM   1717 N  N   . GLU A 1 219 ? 32.32310  8.86343   -2.14398  1.000 76.21234  ? 218 GLU A N   1 
ATOM   1718 C  CA  . GLU A 1 219 ? 32.26266  7.49912   -2.66060  1.000 73.80857  ? 218 GLU A CA  1 
ATOM   1719 C  C   . GLU A 1 219 ? 31.24609  6.66484   -1.88915  1.000 75.26933  ? 218 GLU A C   1 
ATOM   1720 O  O   . GLU A 1 219 ? 30.40984  5.96931   -2.48366  1.000 75.70965  ? 218 GLU A O   1 
ATOM   1721 C  CB  . GLU A 1 219 ? 33.64461  6.84930   -2.59377  1.000 75.38427  ? 218 GLU A CB  1 
ATOM   1722 C  CG  . GLU A 1 219 ? 34.76743  7.70677   -3.15010  1.000 82.41554  ? 218 GLU A CG  1 
ATOM   1723 C  CD  . GLU A 1 219 ? 35.53959  8.42143   -2.06171  1.000 88.26351  ? 218 GLU A CD  1 
ATOM   1724 O  OE1 . GLU A 1 219 ? 36.19342  7.73502   -1.24948  1.000 81.27980  ? 218 GLU A OE1 1 
ATOM   1725 O  OE2 . GLU A 1 219 ? 35.48728  9.66899   -2.00998  1.000 85.35989  ? 218 GLU A OE2 1 
ATOM   1726 N  N   . ALA A 1 220 ? 31.30068  6.72658   -0.55510  1.000 70.09554  ? 219 ALA A N   1 
ATOM   1727 C  CA  . ALA A 1 220 ? 30.34457  5.97716   0.24988   1.000 67.62069  ? 219 ALA A CA  1 
ATOM   1728 C  C   . ALA A 1 220 ? 28.92586  6.48539   0.04302   1.000 65.32289  ? 219 ALA A C   1 
ATOM   1729 O  O   . ALA A 1 220 ? 27.97194  5.70511   0.12296   1.000 63.16798  ? 219 ALA A O   1 
ATOM   1730 C  CB  . ALA A 1 220 ? 30.72555  6.04779   1.72644   1.000 63.03067  ? 219 ALA A CB  1 
ATOM   1731 N  N   . ILE A 1 221 ? 28.76609  7.78369   -0.22628  1.000 63.54131  ? 220 ILE A N   1 
ATOM   1732 C  CA  . ILE A 1 221 ? 27.43726  8.33579   -0.48101  1.000 65.32366  ? 220 ILE A CA  1 
ATOM   1733 C  C   . ILE A 1 221 ? 26.84455  7.71559   -1.73796  1.000 64.38638  ? 220 ILE A C   1 
ATOM   1734 O  O   . ILE A 1 221 ? 25.69110  7.26419   -1.74862  1.000 64.85901  ? 220 ILE A O   1 
ATOM   1735 C  CB  . ILE A 1 221 ? 27.50373  9.87007   -0.59207  1.000 70.89573  ? 220 ILE A CB  1 
ATOM   1736 C  CG1 . ILE A 1 221 ? 27.86326  10.50032  0.75427   1.000 73.68157  ? 220 ILE A CG1 1 
ATOM   1737 C  CG2 . ILE A 1 221 ? 26.18450  10.42460  -1.11172  1.000 66.78287  ? 220 ILE A CG2 1 
ATOM   1738 C  CD1 . ILE A 1 221 ? 26.66830  10.78576  1.65209   1.000 69.45230  ? 220 ILE A CD1 1 
ATOM   1739 N  N   . GLU A 1 222 ? 27.63203  7.68063   -2.81785  1.000 71.02305  ? 221 GLU A N   1 
ATOM   1740 C  CA  . GLU A 1 222 ? 27.15789  7.05821   -4.05031  1.000 67.04196  ? 221 GLU A CA  1 
ATOM   1741 C  C   . GLU A 1 222 ? 26.90342  5.56915   -3.85044  1.000 63.60944  ? 221 GLU A C   1 
ATOM   1742 O  O   . GLU A 1 222 ? 25.96718  5.00788   -4.43313  1.000 66.93711  ? 221 GLU A O   1 
ATOM   1743 C  CB  . GLU A 1 222 ? 28.16292  7.29129   -5.17597  1.000 75.24907  ? 221 GLU A CB  1 
ATOM   1744 C  CG  . GLU A 1 222 ? 28.15607  8.71048   -5.71031  1.000 81.71507  ? 221 GLU A CG  1 
ATOM   1745 C  CD  . GLU A 1 222 ? 27.06028  8.93751   -6.73500  1.000 85.08312  ? 221 GLU A CD  1 
ATOM   1746 O  OE1 . GLU A 1 222 ? 26.50300  7.94046   -7.24287  1.000 76.12319  ? 221 GLU A OE1 1 
ATOM   1747 O  OE2 . GLU A 1 222 ? 26.75761  10.11035  -7.04017  1.000 88.57136  ? 221 GLU A OE2 1 
ATOM   1748 N  N   . ALA A 1 223 ? 27.72500  4.91314   -3.02435  1.000 60.86514  ? 222 ALA A N   1 
ATOM   1749 C  CA  . ALA A 1 223 ? 27.50501  3.49954   -2.72739  1.000 61.99668  ? 222 ALA A CA  1 
ATOM   1750 C  C   . ALA A 1 223 ? 26.15922  3.28274   -2.03991  1.000 60.98274  ? 222 ALA A C   1 
ATOM   1751 O  O   . ALA A 1 223 ? 25.39313  2.37603   -2.40658  1.000 69.31277  ? 222 ALA A O   1 
ATOM   1752 C  CB  . ALA A 1 223 ? 28.64943  2.96558   -1.86599  1.000 55.68627  ? 222 ALA A CB  1 
ATOM   1753 N  N   . VAL A 1 224 ? 25.85898  4.10313   -1.02867  1.000 52.31447  ? 223 VAL A N   1 
ATOM   1754 C  CA  . VAL A 1 224 ? 24.57581  3.98468   -0.34155  1.000 52.99051  ? 223 VAL A CA  1 
ATOM   1755 C  C   . VAL A 1 224 ? 23.43856  4.26007   -1.31369  1.000 49.78678  ? 223 VAL A C   1 
ATOM   1756 O  O   . VAL A 1 224 ? 22.39888  3.58436   -1.28655  1.000 48.68647  ? 223 VAL A O   1 
ATOM   1757 C  CB  . VAL A 1 224 ? 24.52183  4.91537   0.88695   1.000 48.78295  ? 223 VAL A CB  1 
ATOM   1758 C  CG1 . VAL A 1 224 ? 23.14556  4.86368   1.53529   1.000 41.12024  ? 223 VAL A CG1 1 
ATOM   1759 C  CG2 . VAL A 1 224 ? 25.58841  4.52134   1.89082   1.000 51.96548  ? 223 VAL A CG2 1 
ATOM   1760 N  N   . LYS A 1 225 ? 23.62752  5.23950   -2.20453  1.000 53.91434  ? 224 LYS A N   1 
ATOM   1761 C  CA  . LYS A 1 225 ? 22.60707  5.52837   -3.20713  1.000 55.43452  ? 224 LYS A CA  1 
ATOM   1762 C  C   . LYS A 1 225 ? 22.34337  4.31240   -4.09170  1.000 55.09532  ? 224 LYS A C   1 
ATOM   1763 O  O   . LYS A 1 225 ? 21.18702  3.95811   -4.35548  1.000 53.19064  ? 224 LYS A O   1 
ATOM   1764 C  CB  . LYS A 1 225 ? 23.02669  6.72986   -4.05326  1.000 60.65390  ? 224 LYS A CB  1 
ATOM   1765 C  CG  . LYS A 1 225 ? 22.92071  8.07102   -3.34056  1.000 65.86709  ? 224 LYS A CG  1 
ATOM   1766 C  CD  . LYS A 1 225 ? 22.72505  9.21235   -4.32519  1.000 63.19416  ? 224 LYS A CD  1 
ATOM   1767 C  CE  . LYS A 1 225 ? 23.99156  9.51806   -5.09347  1.000 75.32574  ? 224 LYS A CE  1 
ATOM   1768 N  NZ  . LYS A 1 225 ? 24.97898  10.22965  -4.24292  1.000 77.04490  ? 224 LYS A NZ  1 
ATOM   1769 N  N   . ILE A 1 226 ? 23.40863  3.64976   -4.54389  1.000 48.87952  ? 225 ILE A N   1 
ATOM   1770 C  CA  . ILE A 1 226 ? 23.25289  2.49636   -5.42832  1.000 60.53456  ? 225 ILE A CA  1 
ATOM   1771 C  C   . ILE A 1 226 ? 22.49674  1.37610   -4.71998  1.000 60.24626  ? 225 ILE A C   1 
ATOM   1772 O  O   . ILE A 1 226 ? 21.55883  0.78250   -5.27740  1.000 52.52550  ? 225 ILE A O   1 
ATOM   1773 C  CB  . ILE A 1 226 ? 24.62711  2.01844   -5.92950  1.000 62.34290  ? 225 ILE A CB  1 
ATOM   1774 C  CG1 . ILE A 1 226 ? 25.30609  3.11044   -6.75394  1.000 57.51765  ? 225 ILE A CG1 1 
ATOM   1775 C  CG2 . ILE A 1 226 ? 24.47950  0.74912   -6.74999  1.000 56.40626  ? 225 ILE A CG2 1 
ATOM   1776 C  CD1 . ILE A 1 226 ? 26.78499  2.88238   -6.96863  1.000 61.90322  ? 225 ILE A CD1 1 
ATOM   1777 N  N   . GLU A 1 227 ? 22.88952  1.07098   -3.47657  1.000 46.93528  ? 226 GLU A N   1 
ATOM   1778 C  CA  . GLU A 1 227 ? 22.22002  -0.01293  -2.75766  1.000 55.31043  ? 226 GLU A CA  1 
ATOM   1779 C  C   . GLU A 1 227 ? 20.75015  0.31423   -2.50781  1.000 55.78417  ? 226 GLU A C   1 
ATOM   1780 O  O   . GLU A 1 227 ? 19.87334  -0.55011  -2.65686  1.000 55.72485  ? 226 GLU A O   1 
ATOM   1781 C  CB  . GLU A 1 227 ? 22.92655  -0.32040  -1.43804  1.000 65.34241  ? 226 GLU A CB  1 
ATOM   1782 C  CG  . GLU A 1 227 ? 22.33981  -1.54586  -0.75856  1.000 65.07556  ? 226 GLU A CG  1 
ATOM   1783 C  CD  . GLU A 1 227 ? 23.00769  -1.88319  0.55206   1.000 88.69619  ? 226 GLU A CD  1 
ATOM   1784 O  OE1 . GLU A 1 227 ? 23.90445  -1.13544  0.99745   1.000 94.67009  ? 226 GLU A OE1 1 
ATOM   1785 O  OE2 . GLU A 1 227 ? 22.63091  -2.91047  1.14972   1.000 81.14600  ? 226 GLU A OE2 1 
ATOM   1786 N  N   . LEU A 1 228 ? 20.46063  1.55875   -2.11070  1.000 58.22839  ? 227 LEU A N   1 
ATOM   1787 C  CA  . LEU A 1 228 ? 19.07803  1.93535   -1.83223  1.000 56.10524  ? 227 LEU A CA  1 
ATOM   1788 C  C   . LEU A 1 228 ? 18.22469  1.88772   -3.09497  1.000 54.99555  ? 227 LEU A C   1 
ATOM   1789 O  O   . LEU A 1 228 ? 17.05820  1.47434   -3.04901  1.000 54.71360  ? 227 LEU A O   1 
ATOM   1790 C  CB  . LEU A 1 228 ? 19.02748  3.31838   -1.18415  1.000 44.81564  ? 227 LEU A CB  1 
ATOM   1791 C  CG  . LEU A 1 228 ? 19.49431  3.38946   0.27253   1.000 57.69707  ? 227 LEU A CG  1 
ATOM   1792 C  CD1 . LEU A 1 228 ? 19.31833  4.79220   0.84432   1.000 49.81732  ? 227 LEU A CD1 1 
ATOM   1793 C  CD2 . LEU A 1 228 ? 18.74817  2.36220   1.11429   1.000 60.39819  ? 227 LEU A CD2 1 
ATOM   1794 N  N   . ALA A 1 229 ? 18.79223  2.28866   -4.23805  1.000 55.49257  ? 228 ALA A N   1 
ATOM   1795 C  CA  . ALA A 1 229 ? 18.05388  2.18344   -5.49358  1.000 62.23896  ? 228 ALA A CA  1 
ATOM   1796 C  C   . ALA A 1 229 ? 17.75889  0.72869   -5.83537  1.000 58.19976  ? 228 ALA A C   1 
ATOM   1797 O  O   . ALA A 1 229 ? 16.64128  0.39421   -6.25926  1.000 59.45615  ? 228 ALA A O   1 
ATOM   1798 C  CB  . ALA A 1 229 ? 18.83786  2.84510   -6.62578  1.000 51.40664  ? 228 ALA A CB  1 
ATOM   1799 N  N   . SER A 1 230 ? 18.74856  -0.15044  -5.64863  1.000 60.30436  ? 229 SER A N   1 
ATOM   1800 C  CA  . SER A 1 230 ? 18.53639  -1.56862  -5.92069  1.000 50.94641  ? 229 SER A CA  1 
ATOM   1801 C  C   . SER A 1 230 ? 17.40729  -2.12118  -5.05841  1.000 62.87642  ? 229 SER A C   1 
ATOM   1802 O  O   . SER A 1 230 ? 16.51994  -2.83557  -5.54711  1.000 74.01401  ? 229 SER A O   1 
ATOM   1803 C  CB  . SER A 1 230 ? 19.82919  -2.34666  -5.67206  1.000 53.78819  ? 229 SER A CB  1 
ATOM   1804 O  OG  . SER A 1 230 ? 20.93576  -1.72960  -6.30551  1.000 57.64028  ? 229 SER A OG  1 
ATOM   1805 N  N   . LEU A 1 231 ? 17.42087  -1.78496  -3.76479  1.000 49.83509  ? 230 LEU A N   1 
ATOM   1806 C  CA  . LEU A 1 231 ? 16.40449  -2.30228  -2.85468  1.000 50.85024  ? 230 LEU A CA  1 
ATOM   1807 C  C   . LEU A 1 231 ? 15.02399  -1.72897  -3.16063  1.000 49.76609  ? 230 LEU A C   1 
ATOM   1808 O  O   . LEU A 1 231 ? 14.01766  -2.43597  -3.02426  1.000 55.45060  ? 230 LEU A O   1 
ATOM   1809 C  CB  . LEU A 1 231 ? 16.81170  -2.00790  -1.41068  1.000 49.26662  ? 230 LEU A CB  1 
ATOM   1810 C  CG  . LEU A 1 231 ? 18.12507  -2.66518  -0.96842  1.000 48.89672  ? 230 LEU A CG  1 
ATOM   1811 C  CD1 . LEU A 1 231 ? 18.66081  -2.05417  0.31164   1.000 55.36250  ? 230 LEU A CD1 1 
ATOM   1812 C  CD2 . LEU A 1 231 ? 17.94016  -4.16409  -0.80686  1.000 49.83203  ? 230 LEU A CD2 1 
ATOM   1813 N  N   . ALA A 1 232 ? 14.95108  -0.46003  -3.57404  1.000 49.03470  ? 231 ALA A N   1 
ATOM   1814 C  CA  . ALA A 1 232 ? 13.66563  0.10923   -3.96652  1.000 52.94177  ? 231 ALA A CA  1 
ATOM   1815 C  C   . ALA A 1 232 ? 13.09906  -0.61018  -5.18355  1.000 53.15987  ? 231 ALA A C   1 
ATOM   1816 O  O   . ALA A 1 232 ? 11.89868  -0.92215  -5.23374  1.000 51.61870  ? 231 ALA A O   1 
ATOM   1817 C  CB  . ALA A 1 232 ? 13.81817  1.60346   -4.24480  1.000 55.10169  ? 231 ALA A CB  1 
ATOM   1818 N  N   . LYS A 1 233 ? 13.95218  -0.89120  -6.17296  1.000 60.71004  ? 232 LYS A N   1 
ATOM   1819 C  CA  . LYS A 1 233 ? 13.49838  -1.64187  -7.33944  1.000 59.49730  ? 232 LYS A CA  1 
ATOM   1820 C  C   . LYS A 1 233 ? 12.98062  -3.01339  -6.93184  1.000 55.63815  ? 232 LYS A C   1 
ATOM   1821 O  O   . LYS A 1 233 ? 11.92568  -3.45620  -7.39948  1.000 54.09319  ? 232 LYS A O   1 
ATOM   1822 C  CB  . LYS A 1 233 ? 14.63400  -1.79243  -8.34980  1.000 61.85327  ? 232 LYS A CB  1 
ATOM   1823 C  CG  . LYS A 1 233 ? 15.16019  -0.49234  -8.92540  1.000 65.19048  ? 232 LYS A CG  1 
ATOM   1824 C  CD  . LYS A 1 233 ? 16.31443  -0.78030  -9.87118  1.000 65.85029  ? 232 LYS A CD  1 
ATOM   1825 C  CE  . LYS A 1 233 ? 17.06935  0.47306   -10.26824 1.000 70.62881  ? 232 LYS A CE  1 
ATOM   1826 N  NZ  . LYS A 1 233 ? 18.19238  0.12958   -11.18527 1.000 86.31022  ? 232 LYS A NZ  1 
ATOM   1827 N  N   . LYS A 1 234 ? 13.72689  -3.70778  -6.06710  1.000 60.60152  ? 233 LYS A N   1 
ATOM   1828 C  CA  . LYS A 1 234 ? 13.31676  -5.04424  -5.64169  1.000 53.49988  ? 233 LYS A CA  1 
ATOM   1829 C  C   . LYS A 1 234 ? 11.98801  -5.00726  -4.89522  1.000 50.88268  ? 233 LYS A C   1 
ATOM   1830 O  O   . LYS A 1 234 ? 11.13304  -5.88370  -5.08209  1.000 51.09295  ? 233 LYS A O   1 
ATOM   1831 C  CB  . LYS A 1 234 ? 14.40141  -5.67249  -4.76983  1.000 52.90622  ? 233 LYS A CB  1 
ATOM   1832 C  CG  . LYS A 1 234 ? 13.95177  -6.93717  -4.05241  1.000 63.20262  ? 233 LYS A CG  1 
ATOM   1833 C  CD  . LYS A 1 234 ? 13.82116  -8.10965  -5.00483  1.000 62.10079  ? 233 LYS A CD  1 
ATOM   1834 C  CE  . LYS A 1 234 ? 15.13260  -8.84885  -5.10989  1.000 70.60620  ? 233 LYS A CE  1 
ATOM   1835 N  NZ  . LYS A 1 234 ? 15.58118  -9.33548  -3.77751  1.000 67.95716  ? 233 LYS A NZ  1 
ATOM   1836 N  N   . HIS A 1 235 ? 11.80854  -4.00995  -4.02820  1.000 46.98711  ? 234 HIS A N   1 
ATOM   1837 C  CA  . HIS A 1 235 ? 10.54863  -3.85387  -3.31250  1.000 53.64711  ? 234 HIS A CA  1 
ATOM   1838 C  C   . HIS A 1 235 ? 9.39172   -3.67596  -4.28290  1.000 50.27909  ? 234 HIS A C   1 
ATOM   1839 O  O   . HIS A 1 235 ? 8.34245   -4.32211  -4.14341  1.000 44.46892  ? 234 HIS A O   1 
ATOM   1840 C  CB  . HIS A 1 235 ? 10.65587  -2.65602  -2.37013  1.000 54.14425  ? 234 HIS A CB  1 
ATOM   1841 C  CG  . HIS A 1 235 ? 9.44936   -2.43817  -1.51298  1.000 52.71083  ? 234 HIS A CG  1 
ATOM   1842 N  ND1 . HIS A 1 235 ? 8.87053   -3.44596  -0.77306  1.000 53.62942  ? 234 HIS A ND1 1 
ATOM   1843 C  CD2 . HIS A 1 235 ? 8.72707   -1.32154  -1.25759  1.000 50.46048  ? 234 HIS A CD2 1 
ATOM   1844 C  CE1 . HIS A 1 235 ? 7.83783   -2.96306  -0.10539  1.000 50.52151  ? 234 HIS A CE1 1 
ATOM   1845 N  NE2 . HIS A 1 235 ? 7.72868   -1.67642  -0.38242  1.000 54.75328  ? 234 HIS A NE2 1 
ATOM   1846 N  N   . GLN A 1 236 ? 9.57863   -2.82456  -5.29554  1.000 55.38990  ? 235 GLN A N   1 
ATOM   1847 C  CA  . GLN A 1 236 ? 8.51178   -2.61938  -6.26815  1.000 55.70204  ? 235 GLN A CA  1 
ATOM   1848 C  C   . GLN A 1 236 ? 8.24081   -3.87976  -7.08073  1.000 47.91828  ? 235 GLN A C   1 
ATOM   1849 O  O   . GLN A 1 236 ? 7.07682   -4.19695  -7.35376  1.000 47.23008  ? 235 GLN A O   1 
ATOM   1850 C  CB  . GLN A 1 236 ? 8.85265   -1.44490  -7.18215  1.000 52.15414  ? 235 GLN A CB  1 
ATOM   1851 C  CG  . GLN A 1 236 ? 8.85339   -0.10809  -6.46488  1.000 50.45077  ? 235 GLN A CG  1 
ATOM   1852 C  CD  . GLN A 1 236 ? 7.54861   0.15397   -5.73735  1.000 54.42434  ? 235 GLN A CD  1 
ATOM   1853 O  OE1 . GLN A 1 236 ? 7.54012   0.54721   -4.56922  1.000 46.51816  ? 235 GLN A OE1 1 
ATOM   1854 N  NE2 . GLN A 1 236 ? 6.43516   -0.05881  -6.42912  1.000 54.31431  ? 235 GLN A NE2 1 
ATOM   1855 N  N   . GLN A 1 237 ? 9.28921   -4.62387  -7.44638  1.000 49.55322  ? 236 GLN A N   1 
ATOM   1856 C  CA  . GLN A 1 237 ? 9.08724   -5.86479  -8.19069  1.000 59.72611  ? 236 GLN A CA  1 
ATOM   1857 C  C   . GLN A 1 237 ? 8.28053   -6.86498  -7.37722  1.000 57.63153  ? 236 GLN A C   1 
ATOM   1858 O  O   . GLN A 1 237 ? 7.37604   -7.51935  -7.90730  1.000 56.13826  ? 236 GLN A O   1 
ATOM   1859 C  CB  . GLN A 1 237 ? 10.42231  -6.50614  -8.56592  1.000 54.24609  ? 236 GLN A CB  1 
ATOM   1860 C  CG  . GLN A 1 237 ? 11.36798  -5.69644  -9.41561  1.000 53.84617  ? 236 GLN A CG  1 
ATOM   1861 C  CD  . GLN A 1 237 ? 12.70355  -6.40151  -9.56192  1.000 69.97476  ? 236 GLN A CD  1 
ATOM   1862 O  OE1 . GLN A 1 237 ? 12.75738  -7.61789  -9.75603  1.000 77.36008  ? 236 GLN A OE1 1 
ATOM   1863 N  NE2 . GLN A 1 237 ? 13.78833  -5.64794  -9.44246  1.000 64.22787  ? 236 GLN A NE2 1 
ATOM   1864 N  N   . GLN A 1 238 ? 8.61308   -7.01589  -6.09180  1.000 49.14258  ? 237 GLN A N   1 
ATOM   1865 C  CA  . GLN A 1 238 ? 7.89438   -7.97310  -5.25586  1.000 49.93402  ? 237 GLN A CA  1 
ATOM   1866 C  C   . GLN A 1 238 ? 6.44268   -7.55493  -5.05442  1.000 47.74866  ? 237 GLN A C   1 
ATOM   1867 O  O   . GLN A 1 238 ? 5.53558   -8.40204  -5.07205  1.000 51.87731  ? 237 GLN A O   1 
ATOM   1868 C  CB  . GLN A 1 238 ? 8.60563   -8.13430  -3.91387  1.000 51.88542  ? 237 GLN A CB  1 
ATOM   1869 C  CG  . GLN A 1 238 ? 9.97857   -8.79194  -4.00920  1.000 51.87233  ? 237 GLN A CG  1 
ATOM   1870 C  CD  . GLN A 1 238 ? 10.69273  -8.85637  -2.66661  1.000 56.19209  ? 237 GLN A CD  1 
ATOM   1871 O  OE1 . GLN A 1 238 ? 10.14862  -8.45080  -1.64066  1.000 51.21264  ? 237 GLN A OE1 1 
ATOM   1872 N  NE2 . GLN A 1 238 ? 11.91980  -9.36898  -2.67128  1.000 58.98815  ? 237 GLN A NE2 1 
ATOM   1873 N  N   . LEU A 1 239 ? 6.20073   -6.25515  -4.85527  1.000 50.55922  ? 238 LEU A N   1 
ATOM   1874 C  CA  . LEU A 1 239 ? 4.82124   -5.78777  -4.74578  1.000 51.72834  ? 238 LEU A CA  1 
ATOM   1875 C  C   . LEU A 1 239 ? 4.04271   -6.07226  -6.02657  1.000 53.22078  ? 238 LEU A C   1 
ATOM   1876 O  O   . LEU A 1 239 ? 2.88070   -6.51090  -5.98380  1.000 59.48969  ? 238 LEU A O   1 
ATOM   1877 C  CB  . LEU A 1 239 ? 4.79891   -4.29507  -4.42553  1.000 44.73300  ? 238 LEU A CB  1 
ATOM   1878 C  CG  . LEU A 1 239 ? 5.46704   -3.91493  -3.10237  1.000 52.55348  ? 238 LEU A CG  1 
ATOM   1879 C  CD1 . LEU A 1 239 ? 5.34709   -2.43517  -2.78620  1.000 48.13779  ? 238 LEU A CD1 1 
ATOM   1880 C  CD2 . LEU A 1 239 ? 4.87721   -4.73165  -1.99651  1.000 41.29756  ? 238 LEU A CD2 1 
ATOM   1881 N  N   . GLN A 1 240 ? 4.68171   -5.85398  -7.18038  1.000 54.71488  ? 239 GLN A N   1 
ATOM   1882 C  CA  . GLN A 1 240 ? 4.02829   -6.13880  -8.45300  1.000 57.92589  ? 239 GLN A CA  1 
ATOM   1883 C  C   . GLN A 1 240 ? 3.75268   -7.62645  -8.61077  1.000 55.15045  ? 239 GLN A C   1 
ATOM   1884 O  O   . GLN A 1 240 ? 2.71095   -8.01651  -9.14832  1.000 53.17466  ? 239 GLN A O   1 
ATOM   1885 C  CB  . GLN A 1 240 ? 4.88403   -5.63262  -9.61231  1.000 63.50640  ? 239 GLN A CB  1 
ATOM   1886 C  CG  . GLN A 1 240 ? 4.21519   -5.74551  -10.96925 1.000 62.63445  ? 239 GLN A CG  1 
ATOM   1887 C  CD  . GLN A 1 240 ? 2.98929   -4.86629  -11.07493 1.000 67.30454  ? 239 GLN A CD  1 
ATOM   1888 O  OE1 . GLN A 1 240 ? 1.88592   -5.34208  -11.34828 1.000 77.99746  ? 239 GLN A OE1 1 
ATOM   1889 N  NE2 . GLN A 1 240 ? 3.17630   -3.57050  -10.85603 1.000 76.37601  ? 239 GLN A NE2 1 
ATOM   1890 N  N   . LYS A 1 241 ? 4.68481   -8.46812  -8.16338  1.000 50.78815  ? 240 LYS A N   1 
ATOM   1891 C  CA  . LYS A 1 241 ? 4.48630   -9.90920  -8.25395  1.000 57.88163  ? 240 LYS A CA  1 
ATOM   1892 C  C   . LYS A 1 241 ? 3.30530   -10.35296 -7.39749  1.000 57.59580  ? 240 LYS A C   1 
ATOM   1893 O  O   . LYS A 1 241 ? 2.49074   -11.17982 -7.82871  1.000 55.19251  ? 240 LYS A O   1 
ATOM   1894 C  CB  . LYS A 1 241 ? 5.76462   -10.63850 -7.84156  1.000 54.63263  ? 240 LYS A CB  1 
ATOM   1895 C  CG  . LYS A 1 241 ? 6.04826   -11.89010 -8.65042  1.000 68.41155  ? 240 LYS A CG  1 
ATOM   1896 C  CD  . LYS A 1 241 ? 7.30920   -12.58767 -8.16935  1.000 71.26479  ? 240 LYS A CD  1 
ATOM   1897 C  CE  . LYS A 1 241 ? 7.62067   -13.80192 -9.02791  1.000 63.86603  ? 240 LYS A CE  1 
ATOM   1898 N  NZ  . LYS A 1 241 ? 8.80887   -14.53701 -8.51375  1.000 67.45654  ? 240 LYS A NZ  1 
ATOM   1899 N  N   . TYR A 1 242 ? 3.19334   -9.80791  -6.17915  1.000 52.53582  ? 241 TYR A N   1 
ATOM   1900 C  CA  . TYR A 1 242 ? 2.04050   -10.11913 -5.33483  1.000 51.55761  ? 241 TYR A CA  1 
ATOM   1901 C  C   . TYR A 1 242 ? 0.74517   -9.60742  -5.94611  1.000 54.85219  ? 241 TYR A C   1 
ATOM   1902 O  O   . TYR A 1 242 ? -0.31873  -10.20315 -5.73337  1.000 55.55300  ? 241 TYR A O   1 
ATOM   1903 C  CB  . TYR A 1 242 ? 2.22907   -9.54007  -3.92963  1.000 50.17331  ? 241 TYR A CB  1 
ATOM   1904 C  CG  . TYR A 1 242 ? 1.05951   -9.77436  -2.98211  1.000 46.05404  ? 241 TYR A CG  1 
ATOM   1905 C  CD1 . TYR A 1 242 ? 0.57768   -11.05720 -2.73742  1.000 53.42564  ? 241 TYR A CD1 1 
ATOM   1906 C  CD2 . TYR A 1 242 ? 0.45555   -8.71534  -2.31250  1.000 54.86720  ? 241 TYR A CD2 1 
ATOM   1907 C  CE1 . TYR A 1 242 ? -0.48755  -11.27625 -1.86795  1.000 55.12319  ? 241 TYR A CE1 1 
ATOM   1908 C  CE2 . TYR A 1 242 ? -0.60685  -8.92710  -1.43926  1.000 56.89195  ? 241 TYR A CE2 1 
ATOM   1909 C  CZ  . TYR A 1 242 ? -1.07298  -10.20562 -1.22142  1.000 56.90345  ? 241 TYR A CZ  1 
ATOM   1910 O  OH  . TYR A 1 242 ? -2.12456  -10.41269 -0.35823  1.000 58.97067  ? 241 TYR A OH  1 
ATOM   1911 N  N   . LYS A 1 243 ? 0.80550   -8.49715  -6.68406  1.000 55.63348  ? 242 LYS A N   1 
ATOM   1912 C  CA  . LYS A 1 243 ? -0.38023  -8.05756  -7.41328  1.000 66.35676  ? 242 LYS A CA  1 
ATOM   1913 C  C   . LYS A 1 243 ? -0.70750  -9.01187  -8.56052  1.000 58.34171  ? 242 LYS A C   1 
ATOM   1914 O  O   . LYS A 1 243 ? -1.88243  -9.28467  -8.83778  1.000 55.86150  ? 242 LYS A O   1 
ATOM   1915 C  CB  . LYS A 1 243 ? -0.18464  -6.63505  -7.93154  1.000 64.78394  ? 242 LYS A CB  1 
ATOM   1916 C  CG  . LYS A 1 243 ? -1.34324  -6.12644  -8.77006  1.000 73.09183  ? 242 LYS A CG  1 
ATOM   1917 C  CD  . LYS A 1 243 ? -1.03950  -4.75489  -9.34137  1.000 80.90751  ? 242 LYS A CD  1 
ATOM   1918 C  CE  . LYS A 1 243 ? -1.75026  -4.53352  -10.66793 1.000 83.74302  ? 242 LYS A CE  1 
ATOM   1919 N  NZ  . LYS A 1 243 ? -1.26992  -3.28243  -11.31922 1.000 82.40805  ? 242 LYS A NZ  1 
ATOM   1920 N  N   . ASP A 1 244 ? 0.32132   -9.53253  -9.23311  1.000 55.76477  ? 243 ASP A N   1 
ATOM   1921 C  CA  . ASP A 1 244 ? 0.13056   -10.45803 -10.34420 1.000 62.51118  ? 243 ASP A CA  1 
ATOM   1922 C  C   . ASP A 1 244 ? -0.24630  -11.85115 -9.86693  1.000 63.65877  ? 243 ASP A C   1 
ATOM   1923 O  O   . ASP A 1 244 ? -0.94704  -12.57992 -10.57922 1.000 66.70293  ? 243 ASP A O   1 
ATOM   1924 C  CB  . ASP A 1 244 ? 1.40188   -10.53577 -11.19069 1.000 57.43111  ? 243 ASP A CB  1 
ATOM   1925 C  CG  . ASP A 1 244 ? 1.72495   -9.22503  -11.88172 1.000 57.68909  ? 243 ASP A CG  1 
ATOM   1926 O  OD1 . ASP A 1 244 ? 0.80661   -8.38806  -12.03621 1.000 60.96115  ? 243 ASP A OD1 1 
ATOM   1927 O  OD2 . ASP A 1 244 ? 2.89378   -9.03776  -12.28248 1.000 60.68371  ? 243 ASP A OD2 1 
ATOM   1928 N  N   . HIS A 1 245 ? 0.20399   -12.23384 -8.67607  1.000 57.90846  ? 244 HIS A N   1 
ATOM   1929 C  CA  . HIS A 1 245 ? -0.02854  -13.56554 -8.12366  1.000 57.90473  ? 244 HIS A CA  1 
ATOM   1930 C  C   . HIS A 1 245 ? -0.63029  -13.39774 -6.73260  1.000 61.35928  ? 244 HIS A C   1 
ATOM   1931 O  O   . HIS A 1 245 ? 0.03287   -13.64043 -5.71600  1.000 54.24812  ? 244 HIS A O   1 
ATOM   1932 C  CB  . HIS A 1 245 ? 1.27210   -14.37024 -8.08048  1.000 62.03800  ? 244 HIS A CB  1 
ATOM   1933 C  CG  . HIS A 1 245 ? 1.93396   -14.55559 -9.41669  1.000 63.00203  ? 244 HIS A CG  1 
ATOM   1934 N  ND1 . HIS A 1 245 ? 1.84517   -15.72938 -10.13562 1.000 65.57443  ? 244 HIS A ND1 1 
ATOM   1935 C  CD2 . HIS A 1 245 ? 2.72750   -13.73212 -10.14344 1.000 63.46974  ? 244 HIS A CD2 1 
ATOM   1936 C  CE1 . HIS A 1 245 ? 2.54145   -15.61634 -11.25313 1.000 64.92301  ? 244 HIS A CE1 1 
ATOM   1937 N  NE2 . HIS A 1 245 ? 3.08618   -14.41360 -11.28245 1.000 67.81776  ? 244 HIS A NE2 1 
ATOM   1938 N  N   . PRO A 1 246 ? -1.89584  -12.97128 -6.65485  1.000 61.68251  ? 245 PRO A N   1 
ATOM   1939 C  CA  . PRO A 1 246 ? -2.47076  -12.57826 -5.35542  1.000 57.75592  ? 245 PRO A CA  1 
ATOM   1940 C  C   . PRO A 1 246 ? -2.58393  -13.70765 -4.34067  1.000 53.72290  ? 245 PRO A C   1 
ATOM   1941 O  O   . PRO A 1 246 ? -2.75789  -13.41975 -3.14763  1.000 57.08853  ? 245 PRO A O   1 
ATOM   1942 C  CB  . PRO A 1 246 ? -3.85867  -12.04085 -5.73357  1.000 53.15291  ? 245 PRO A CB  1 
ATOM   1943 C  CG  . PRO A 1 246 ? -4.16592  -12.67110 -7.05644  1.000 55.43276  ? 245 PRO A CG  1 
ATOM   1944 C  CD  . PRO A 1 246 ? -2.84946  -12.77357 -7.75940  1.000 56.44340  ? 245 PRO A CD  1 
ATOM   1945 N  N   . LYS A 1 247 ? -2.50763  -14.96736 -4.76946  1.000 62.50282  ? 246 LYS A N   1 
ATOM   1946 C  CA  . LYS A 1 247 ? -2.66661  -16.12208 -3.89391  1.000 55.57579  ? 246 LYS A CA  1 
ATOM   1947 C  C   . LYS A 1 247 ? -1.33783  -16.69368 -3.40989  1.000 55.25625  ? 246 LYS A C   1 
ATOM   1948 O  O   . LYS A 1 247 ? -1.33646  -17.64931 -2.62404  1.000 55.17325  ? 246 LYS A O   1 
ATOM   1949 C  CB  . LYS A 1 247 ? -3.46343  -17.21467 -4.61388  1.000 61.19172  ? 246 LYS A CB  1 
ATOM   1950 C  CG  . LYS A 1 247 ? -4.71181  -16.71511 -5.33280  1.000 60.78646  ? 246 LYS A CG  1 
ATOM   1951 C  CD  . LYS A 1 247 ? -5.77755  -17.79930 -5.43041  1.000 72.22377  ? 246 LYS A CD  1 
ATOM   1952 C  CE  . LYS A 1 247 ? -5.32786  -18.97566 -6.27218  1.000 66.71012  ? 246 LYS A CE  1 
ATOM   1953 N  NZ  . LYS A 1 247 ? -5.00735  -18.57482 -7.66332  1.000 85.91781  ? 246 LYS A NZ  1 
ATOM   1954 N  N   . ASP A 1 248 ? -0.21284  -16.12412 -3.84503  1.000 54.46972  ? 247 ASP A N   1 
ATOM   1955 C  CA  . ASP A 1 248 ? 1.10375   -16.68540 -3.56682  1.000 54.44699  ? 247 ASP A CA  1 
ATOM   1956 C  C   . ASP A 1 248 ? 1.87976   -15.79382 -2.60629  1.000 47.25491  ? 247 ASP A C   1 
ATOM   1957 O  O   . ASP A 1 248 ? 3.08881   -15.59822 -2.77023  1.000 44.68808  ? 247 ASP A O   1 
ATOM   1958 C  CB  . ASP A 1 248 ? 1.87611   -16.88571 -4.87125  1.000 56.47407  ? 247 ASP A CB  1 
ATOM   1959 C  CG  . ASP A 1 248 ? 1.14673   -17.79110 -5.84489  1.000 56.85206  ? 247 ASP A CG  1 
ATOM   1960 O  OD1 . ASP A 1 248 ? 0.64941   -18.85543 -5.42236  1.000 56.74014  ? 247 ASP A OD1 1 
ATOM   1961 O  OD2 . ASP A 1 248 ? 1.05976   -17.43010 -7.03715  1.000 61.79566  ? 247 ASP A OD2 1 
ATOM   1962 N  N   . PHE A 1 249 ? 1.18502   -15.25704 -1.59938  1.000 50.52087  ? 248 PHE A N   1 
ATOM   1963 C  CA  . PHE A 1 249 ? 1.79565   -14.29235 -0.69043  1.000 47.76967  ? 248 PHE A CA  1 
ATOM   1964 C  C   . PHE A 1 249 ? 3.01196   -14.87403 0.02227   1.000 42.88933  ? 248 PHE A C   1 
ATOM   1965 O  O   . PHE A 1 249 ? 4.04746   -14.20848 0.13921   1.000 44.17993  ? 248 PHE A O   1 
ATOM   1966 C  CB  . PHE A 1 249 ? 0.75349   -13.82126 0.32158   1.000 50.94631  ? 248 PHE A CB  1 
ATOM   1967 C  CG  . PHE A 1 249 ? 1.32235   -13.02847 1.46221   1.000 46.67419  ? 248 PHE A CG  1 
ATOM   1968 C  CD1 . PHE A 1 249 ? 1.83037   -11.75533 1.25706   1.000 49.92130  ? 248 PHE A CD1 1 
ATOM   1969 C  CD2 . PHE A 1 249 ? 1.32655   -13.54921 2.74602   1.000 49.06749  ? 248 PHE A CD2 1 
ATOM   1970 C  CE1 . PHE A 1 249 ? 2.34829   -11.01893 2.30888   1.000 41.66189  ? 248 PHE A CE1 1 
ATOM   1971 C  CE2 . PHE A 1 249 ? 1.83921   -12.81784 3.80392   1.000 53.06579  ? 248 PHE A CE2 1 
ATOM   1972 C  CZ  . PHE A 1 249 ? 2.35204   -11.54883 3.58412   1.000 48.31542  ? 248 PHE A CZ  1 
ATOM   1973 N  N   . TYR A 1 250 ? 2.91822   -16.11543 0.49595   1.000 50.07289  ? 249 TYR A N   1 
ATOM   1974 C  CA  . TYR A 1 250 ? 4.02409   -16.68508 1.25479   1.000 49.59747  ? 249 TYR A CA  1 
ATOM   1975 C  C   . TYR A 1 250 ? 5.16115   -17.18085 0.36990   1.000 47.77400  ? 249 TYR A C   1 
ATOM   1976 O  O   . TYR A 1 250 ? 6.23608   -17.49184 0.89080   1.000 44.46200  ? 249 TYR A O   1 
ATOM   1977 C  CB  . TYR A 1 250 ? 3.51233   -17.81287 2.15253   1.000 54.59458  ? 249 TYR A CB  1 
ATOM   1978 C  CG  . TYR A 1 250 ? 2.51340   -17.33902 3.18047   1.000 51.25309  ? 249 TYR A CG  1 
ATOM   1979 C  CD1 . TYR A 1 250 ? 2.93383   -16.74721 4.36260   1.000 47.07158  ? 249 TYR A CD1 1 
ATOM   1980 C  CD2 . TYR A 1 250 ? 1.14803   -17.47470 2.96429   1.000 48.61891  ? 249 TYR A CD2 1 
ATOM   1981 C  CE1 . TYR A 1 250 ? 2.01764   -16.30847 5.30450   1.000 46.18860  ? 249 TYR A CE1 1 
ATOM   1982 C  CE2 . TYR A 1 250 ? 0.22846   -17.04010 3.89993   1.000 49.98601  ? 249 TYR A CE2 1 
ATOM   1983 C  CZ  . TYR A 1 250 ? 0.66736   -16.45872 5.06528   1.000 46.70580  ? 249 TYR A CZ  1 
ATOM   1984 O  OH  . TYR A 1 250 ? -0.25247  -16.02831 5.99206   1.000 47.92673  ? 249 TYR A OH  1 
ATOM   1985 N  N   . HIS A 1 251 ? 4.95700   -17.25423 -0.94571  1.000 49.35481  ? 250 HIS A N   1 
ATOM   1986 C  CA  . HIS A 1 251 ? 6.05957   -17.50177 -1.87047  1.000 50.78544  ? 250 HIS A CA  1 
ATOM   1987 C  C   . HIS A 1 251 ? 6.86830   -16.23343 -2.11450  1.000 51.85819  ? 250 HIS A C   1 
ATOM   1988 O  O   . HIS A 1 251 ? 8.10182   -16.24176 -2.02165  1.000 47.76163  ? 250 HIS A O   1 
ATOM   1989 C  CB  . HIS A 1 251 ? 5.51460   -18.05523 -3.19219  1.000 46.68347  ? 250 HIS A CB  1 
ATOM   1990 C  CG  . HIS A 1 251 ? 6.49783   -18.02112 -4.32289  1.000 45.18238  ? 250 HIS A CG  1 
ATOM   1991 N  ND1 . HIS A 1 251 ? 7.76774   -18.54905 -4.22550  1.000 41.73241  ? 250 HIS A ND1 1 
ATOM   1992 C  CD2 . HIS A 1 251 ? 6.39146   -17.52743 -5.58018  1.000 56.78389  ? 250 HIS A CD2 1 
ATOM   1993 C  CE1 . HIS A 1 251 ? 8.40238   -18.37714 -5.37159  1.000 47.51841  ? 250 HIS A CE1 1 
ATOM   1994 N  NE2 . HIS A 1 251 ? 7.58903   -17.76135 -6.21102  1.000 57.02863  ? 250 HIS A NE2 1 
ATOM   1995 N  N   . ILE A 1 252 ? 6.17647   -15.13481 -2.42341  1.000 45.76102  ? 251 ILE A N   1 
ATOM   1996 C  CA  . ILE A 1 252 ? 6.83798   -13.87635 -2.74885  1.000 49.70339  ? 251 ILE A CA  1 
ATOM   1997 C  C   . ILE A 1 252 ? 7.51872   -13.28447 -1.52011  1.000 48.61797  ? 251 ILE A C   1 
ATOM   1998 O  O   . ILE A 1 252 ? 8.62763   -12.74087 -1.60856  1.000 50.26349  ? 251 ILE A O   1 
ATOM   1999 C  CB  . ILE A 1 252 ? 5.81301   -12.91132 -3.37109  1.000 47.58246  ? 251 ILE A CB  1 
ATOM   2000 C  CG1 . ILE A 1 252 ? 5.40221   -13.41074 -4.76162  1.000 50.91804  ? 251 ILE A CG1 1 
ATOM   2001 C  CG2 . ILE A 1 252 ? 6.36280   -11.49085 -3.43415  1.000 50.50711  ? 251 ILE A CG2 1 
ATOM   2002 C  CD1 . ILE A 1 252 ? 3.90814   -13.32550 -5.05508  1.000 54.16053  ? 251 ILE A CD1 1 
ATOM   2003 N  N   . PHE A 1 253 ? 6.88327   -13.39124 -0.35299  1.000 49.01178  ? 252 PHE A N   1 
ATOM   2004 C  CA  . PHE A 1 253 ? 7.47722   -12.94869 0.90383   1.000 49.70856  ? 252 PHE A CA  1 
ATOM   2005 C  C   . PHE A 1 253 ? 7.69243   -14.18732 1.76895   1.000 50.76791  ? 252 PHE A C   1 
ATOM   2006 O  O   . PHE A 1 253 ? 6.88373   -14.48953 2.65736   1.000 53.93700  ? 252 PHE A O   1 
ATOM   2007 C  CB  . PHE A 1 253 ? 6.59934   -11.91686 1.60383   1.000 43.03128  ? 252 PHE A CB  1 
ATOM   2008 C  CG  . PHE A 1 253 ? 6.25817   -10.72807 0.74821   1.000 48.67246  ? 252 PHE A CG  1 
ATOM   2009 C  CD1 . PHE A 1 253 ? 7.21000   -9.76136  0.46336   1.000 49.06713  ? 252 PHE A CD1 1 
ATOM   2010 C  CD2 . PHE A 1 253 ? 4.97950   -10.57469 0.23763   1.000 46.16690  ? 252 PHE A CD2 1 
ATOM   2011 C  CE1 . PHE A 1 253 ? 6.89485   -8.67324  -0.31990  1.000 52.92851  ? 252 PHE A CE1 1 
ATOM   2012 C  CE2 . PHE A 1 253 ? 4.65733   -9.48670  -0.54282  1.000 43.99027  ? 252 PHE A CE2 1 
ATOM   2013 C  CZ  . PHE A 1 253 ? 5.61492   -8.53592  -0.82355  1.000 47.89274  ? 252 PHE A CZ  1 
ATOM   2014 N  N   . PRO A 1 254 ? 8.78998   -14.90532 1.54795   1.000 57.12752  ? 253 PRO A N   1 
ATOM   2015 C  CA  . PRO A 1 254 ? 8.95343   -16.24348 2.14097   1.000 50.75692  ? 253 PRO A CA  1 
ATOM   2016 C  C   . PRO A 1 254 ? 9.17992   -16.18175 3.63802   1.000 48.78109  ? 253 PRO A C   1 
ATOM   2017 O  O   . PRO A 1 254 ? 9.97519   -15.36320 4.12817   1.000 48.54014  ? 253 PRO A O   1 
ATOM   2018 C  CB  . PRO A 1 254 ? 10.19211  -16.79179 1.41554   1.000 47.74926  ? 253 PRO A CB  1 
ATOM   2019 C  CG  . PRO A 1 254 ? 10.98657  -15.56453 1.08715   1.000 48.77798  ? 253 PRO A CG  1 
ATOM   2020 C  CD  . PRO A 1 254 ? 9.96013   -14.50367 0.75183   1.000 49.23077  ? 253 PRO A CD  1 
ATOM   2021 N  N   . PRO A 1 255 ? 8.53400   -17.06495 4.39789   1.000 57.13709  ? 254 PRO A N   1 
ATOM   2022 C  CA  . PRO A 1 255 ? 8.64353   -17.03218 5.86058   1.000 54.16883  ? 254 PRO A CA  1 
ATOM   2023 C  C   . PRO A 1 255 ? 9.90367   -17.69538 6.39071   1.000 54.42410  ? 254 PRO A C   1 
ATOM   2024 O  O   . PRO A 1 255 ? 10.43507  -18.64248 5.81056   1.000 54.86919  ? 254 PRO A O   1 
ATOM   2025 C  CB  . PRO A 1 255 ? 7.39331   -17.79427 6.31959   1.000 52.32317  ? 254 PRO A CB  1 
ATOM   2026 C  CG  . PRO A 1 255 ? 7.10612   -18.73843 5.19164   1.000 52.01101  ? 254 PRO A CG  1 
ATOM   2027 C  CD  . PRO A 1 255 ? 7.53254   -18.03817 3.92805   1.000 54.70548  ? 254 PRO A CD  1 
ATOM   2028 N  N   . GLN A 1 256 ? 10.38102  -17.16906 7.51458   1.000 49.83423  ? 255 GLN A N   1 
ATOM   2029 C  CA  . GLN A 1 256 ? 11.38845  -17.82923 8.33882   1.000 61.76405  ? 255 GLN A CA  1 
ATOM   2030 C  C   . GLN A 1 256 ? 10.79334  -17.93840 9.73649   1.000 62.24137  ? 255 GLN A C   1 
ATOM   2031 O  O   . GLN A 1 256 ? 10.69093  -16.93549 10.45221  1.000 64.61884  ? 255 GLN A O   1 
ATOM   2032 C  CB  . GLN A 1 256 ? 12.71028  -17.05770 8.34283   1.000 56.60781  ? 255 GLN A CB  1 
ATOM   2033 C  CG  . GLN A 1 256 ? 13.90880  -17.84566 8.85211   1.000 62.55799  ? 255 GLN A CG  1 
ATOM   2034 C  CD  . GLN A 1 256 ? 15.12763  -16.96557 9.01843   1.000 63.41577  ? 255 GLN A CD  1 
ATOM   2035 O  OE1 . GLN A 1 256 ? 15.00684  -15.76004 9.22999   1.000 64.37043  ? 255 GLN A OE1 1 
ATOM   2036 N  NE2 . GLN A 1 256 ? 16.31046  -17.55957 8.91406   1.000 60.90075  ? 255 GLN A NE2 1 
ATOM   2037 N  N   . SER A 1 257 ? 10.39101  -19.14800 10.11237  1.000 64.33651  ? 256 SER A N   1 
ATOM   2038 C  CA  . SER A 1 257 ? 9.59861   -19.38823 11.30802  1.000 61.42977  ? 256 SER A CA  1 
ATOM   2039 C  C   . SER A 1 257 ? 10.48479  -19.75812 12.49474  1.000 71.51023  ? 256 SER A C   1 
ATOM   2040 O  O   . SER A 1 257 ? 11.68959  -19.98304 12.36487  1.000 76.30112  ? 256 SER A O   1 
ATOM   2041 C  CB  . SER A 1 257 ? 8.57025   -20.49150 11.04054  1.000 67.33202  ? 256 SER A CB  1 
ATOM   2042 O  OG  . SER A 1 257 ? 7.82857   -20.19998 9.86733   1.000 71.92137  ? 256 SER A OG  1 
ATOM   2043 N  N   . GLY A 1 258 ? 9.86331   -19.81134 13.67185  1.000 76.75511  ? 257 GLY A N   1 
ATOM   2044 C  CA  . GLY A 1 258 ? 10.56658  -20.18316 14.88581  1.000 79.63640  ? 257 GLY A CA  1 
ATOM   2045 C  C   . GLY A 1 258 ? 10.13159  -19.40877 16.11505  1.000 82.99444  ? 257 GLY A C   1 
ATOM   2046 O  O   . GLY A 1 258 ? 9.03472   -18.84615 16.15068  1.000 81.70779  ? 257 GLY A O   1 
ATOM   2047 N  N   . TYR A 1 259 ? 10.99556  -19.36990 17.13089  1.000 84.58889  ? 258 TYR A N   1 
ATOM   2048 C  CA  . TYR A 1 259 ? 10.66165  -18.70929 18.39015  1.000 86.13521  ? 258 TYR A CA  1 
ATOM   2049 C  C   . TYR A 1 259 ? 10.51540  -17.20036 18.21702  1.000 85.40293  ? 258 TYR A C   1 
ATOM   2050 O  O   . TYR A 1 259 ? 9.71481   -16.56745 18.92115  1.000 85.50988  ? 258 TYR A O   1 
ATOM   2051 C  CB  . TYR A 1 259 ? 11.73258  -19.03342 19.43488  1.000 84.44319  ? 258 TYR A CB  1 
ATOM   2052 C  CG  . TYR A 1 259 ? 13.13356  -18.68373 18.97871  1.000 86.64514  ? 258 TYR A CG  1 
ATOM   2053 C  CD1 . TYR A 1 259 ? 13.82606  -19.50204 18.09235  1.000 82.65489  ? 258 TYR A CD1 1 
ATOM   2054 C  CD2 . TYR A 1 259 ? 13.75847  -17.52812 19.42267  1.000 85.82146  ? 258 TYR A CD2 1 
ATOM   2055 C  CE1 . TYR A 1 259 ? 15.09964  -19.17572 17.66190  1.000 80.82902  ? 258 TYR A CE1 1 
ATOM   2056 C  CE2 . TYR A 1 259 ? 15.03787  -17.19879 19.00273  1.000 80.38898  ? 258 TYR A CE2 1 
ATOM   2057 C  CZ  . TYR A 1 259 ? 15.70352  -18.02715 18.12355  1.000 80.14159  ? 258 TYR A CZ  1 
ATOM   2058 O  OH  . TYR A 1 259 ? 16.97567  -17.71118 17.69881  1.000 71.37764  ? 258 TYR A OH  1 
ATOM   2059 N  N   . VAL A 1 260 ? 11.26523  -16.61323 17.28011  1.000 76.27594  ? 259 VAL A N   1 
ATOM   2060 C  CA  . VAL A 1 260 ? 11.15521  -15.19436 16.97723  1.000 80.43751  ? 259 VAL A CA  1 
ATOM   2061 C  C   . VAL A 1 260 ? 9.77966   -14.83726 16.43835  1.000 78.46757  ? 259 VAL A C   1 
ATOM   2062 O  O   . VAL A 1 260 ? 9.43782   -13.65381 16.34305  1.000 72.38670  ? 259 VAL A O   1 
ATOM   2063 C  CB  . VAL A 1 260 ? 12.27357  -14.79350 15.98827  1.000 79.19119  ? 259 VAL A CB  1 
ATOM   2064 C  CG1 . VAL A 1 260 ? 12.38057  -13.27443 15.85057  1.000 74.89502  ? 259 VAL A CG1 1 
ATOM   2065 C  CG2 . VAL A 1 260 ? 13.60036  -15.37609 16.44005  1.000 79.56864  ? 259 VAL A CG2 1 
ATOM   2066 N  N   . CYS A 1 261 ? 8.96674   -15.83717 16.11394  1.000 74.69875  ? 260 CYS A N   1 
ATOM   2067 C  CA  . CYS A 1 261 ? 7.60178   -15.58537 15.68771  1.000 73.25459  ? 260 CYS A CA  1 
ATOM   2068 C  C   . CYS A 1 261 ? 6.65341   -15.38423 16.85911  1.000 83.16691  ? 260 CYS A C   1 
ATOM   2069 O  O   . CYS A 1 261 ? 5.46085   -15.15838 16.63199  1.000 88.25707  ? 260 CYS A O   1 
ATOM   2070 C  CB  . CYS A 1 261 ? 7.10283   -16.72993 14.80848  1.000 77.55255  ? 260 CYS A CB  1 
ATOM   2071 S  SG  . CYS A 1 261 ? 8.11112   -17.00616 13.33179  1.000 104.66319 ? 260 CYS A SG  1 
ATOM   2072 N  N   . ARG A 1 262 ? 7.14202   -15.47357 18.09647  1.000 83.56629  ? 261 ARG A N   1 
ATOM   2073 C  CA  . ARG A 1 262 ? 6.36819   -15.05949 19.25706  1.000 83.50237  ? 261 ARG A CA  1 
ATOM   2074 C  C   . ARG A 1 262 ? 6.45857   -13.56179 19.48872  1.000 85.22546  ? 261 ARG A C   1 
ATOM   2075 O  O   . ARG A 1 262 ? 5.79425   -13.04552 20.39229  1.000 86.86267  ? 261 ARG A O   1 
ATOM   2076 C  CB  . ARG A 1 262 ? 6.84233   -15.78974 20.51563  1.000 83.27097  ? 261 ARG A CB  1 
ATOM   2077 C  CG  . ARG A 1 262 ? 6.81781   -17.31123 20.43424  1.000 91.83265  ? 261 ARG A CG  1 
ATOM   2078 C  CD  . ARG A 1 262 ? 7.29527   -17.92051 21.74876  1.000 91.80347  ? 261 ARG A CD  1 
ATOM   2079 N  NE  . ARG A 1 262 ? 7.44754   -19.36932 21.68542  1.000 102.44319 ? 261 ARG A NE  1 
ATOM   2080 C  CZ  . ARG A 1 262 ? 7.87926   -20.11566 22.69316  1.000 102.16319 ? 261 ARG A CZ  1 
ATOM   2081 N  NH1 . ARG A 1 262 ? 8.20266   -19.58147 23.85950  1.000 102.41010 ? 261 ARG A NH1 1 
ATOM   2082 N  NH2 . ARG A 1 262 ? 7.99258   -21.42975 22.52642  1.000 105.23318 ? 261 ARG A NH2 1 
ATOM   2083 N  N   . TYR A 1 263 ? 7.27242   -12.86002 18.70029  1.000 80.99442  ? 262 TYR A N   1 
ATOM   2084 C  CA  . TYR A 1 263 ? 7.44075   -11.42342 18.82898  1.000 80.04380  ? 262 TYR A CA  1 
ATOM   2085 C  C   . TYR A 1 263 ? 6.91985   -10.66961 17.62142  1.000 74.23218  ? 262 TYR A C   1 
ATOM   2086 O  O   . TYR A 1 263 ? 6.90292   -9.43338  17.64070  1.000 75.07051  ? 262 TYR A O   1 
ATOM   2087 C  CB  . TYR A 1 263 ? 8.91783   -11.07819 19.05248  1.000 79.70024  ? 262 TYR A CB  1 
ATOM   2088 C  CG  . TYR A 1 263 ? 9.47505   -11.64685 20.33537  1.000 86.44815  ? 262 TYR A CG  1 
ATOM   2089 C  CD1 . TYR A 1 263 ? 9.58535   -10.86301 21.47475  1.000 91.95290  ? 262 TYR A CD1 1 
ATOM   2090 C  CD2 . TYR A 1 263 ? 9.87595   -12.97325 20.41337  1.000 85.42360  ? 262 TYR A CD2 1 
ATOM   2091 C  CE1 . TYR A 1 263 ? 10.09267  -11.38226 22.65624  1.000 92.64983  ? 262 TYR A CE1 1 
ATOM   2092 C  CE2 . TYR A 1 263 ? 10.38093  -13.50412 21.59197  1.000 85.26640  ? 262 TYR A CE2 1 
ATOM   2093 C  CZ  . TYR A 1 263 ? 10.48730  -12.70206 22.71021  1.000 90.52693  ? 262 TYR A CZ  1 
ATOM   2094 O  OH  . TYR A 1 263 ? 10.98662  -13.21357 23.88727  1.000 89.91889  ? 262 TYR A OH  1 
ATOM   2095 N  N   . CYS A 1 264 ? 6.49991   -11.37392 16.57956  1.000 72.07937  ? 263 CYS A N   1 
ATOM   2096 C  CA  . CYS A 1 264 ? 5.95253   -10.71070 15.41441  1.000 69.76694  ? 263 CYS A CA  1 
ATOM   2097 C  C   . CYS A 1 264 ? 4.62947   -10.03939 15.77161  1.000 65.58917  ? 263 CYS A C   1 
ATOM   2098 O  O   . CYS A 1 264 ? 3.81578   -10.61368 16.50728  1.000 57.88612  ? 263 CYS A O   1 
ATOM   2099 C  CB  . CYS A 1 264 ? 5.73239   -11.70797 14.28273  1.000 66.68680  ? 263 CYS A CB  1 
ATOM   2100 S  SG  . CYS A 1 264 ? 5.26305   -10.91889 12.73823  1.000 69.55281  ? 263 CYS A SG  1 
ATOM   2101 N  N   . PRO A 1 265 ? 4.38328   -8.82741  15.26925  1.000 60.78050  ? 264 PRO A N   1 
ATOM   2102 C  CA  . PRO A 1 265 ? 3.05399   -8.22384  15.42964  1.000 56.57640  ? 264 PRO A CA  1 
ATOM   2103 C  C   . PRO A 1 265 ? 1.95870   -9.01168  14.73413  1.000 60.96762  ? 264 PRO A C   1 
ATOM   2104 O  O   . PRO A 1 265 ? 0.77495   -8.73693  14.97849  1.000 59.21249  ? 264 PRO A O   1 
ATOM   2105 C  CB  . PRO A 1 265 ? 3.21812   -6.83521  14.79768  1.000 60.03788  ? 264 PRO A CB  1 
ATOM   2106 C  CG  . PRO A 1 265 ? 4.69238   -6.57665  14.81163  1.000 55.34968  ? 264 PRO A CG  1 
ATOM   2107 C  CD  . PRO A 1 265 ? 5.33061   -7.91312  14.61298  1.000 63.30930  ? 264 PRO A CD  1 
ATOM   2108 N  N   . PHE A 1 266 ? 2.31521   -9.98699  13.89222  1.000 60.12992  ? 265 PHE A N   1 
ATOM   2109 C  CA  . PHE A 1 266 ? 1.35847   -10.69293 13.05127  1.000 58.53840  ? 265 PHE A CA  1 
ATOM   2110 C  C   . PHE A 1 266 ? 1.19866   -12.16382 13.41522  1.000 60.89961  ? 265 PHE A C   1 
ATOM   2111 O  O   . PHE A 1 266 ? 0.59584   -12.91072 12.63747  1.000 60.05729  ? 265 PHE A O   1 
ATOM   2112 C  CB  . PHE A 1 266 ? 1.76652   -10.56946 11.58085  1.000 63.17736  ? 265 PHE A CB  1 
ATOM   2113 C  CG  . PHE A 1 266 ? 2.18084   -9.18439  11.18737  1.000 59.23889  ? 265 PHE A CG  1 
ATOM   2114 C  CD1 . PHE A 1 266 ? 1.25763   -8.15742  11.15267  1.000 61.40373  ? 265 PHE A CD1 1 
ATOM   2115 C  CD2 . PHE A 1 266 ? 3.49719   -8.90670  10.86325  1.000 54.20537  ? 265 PHE A CD2 1 
ATOM   2116 C  CE1 . PHE A 1 266 ? 1.63763   -6.87979  10.80066  1.000 58.28228  ? 265 PHE A CE1 1 
ATOM   2117 C  CE2 . PHE A 1 266 ? 3.88365   -7.62974  10.51437  1.000 61.14633  ? 265 PHE A CE2 1 
ATOM   2118 C  CZ  . PHE A 1 266 ? 2.95208   -6.61610  10.47883  1.000 56.04212  ? 265 PHE A CZ  1 
ATOM   2119 N  N   . THR A 1 267 ? 1.69247   -12.59627 14.57995  1.000 60.57555  ? 266 THR A N   1 
ATOM   2120 C  CA  . THR A 1 267 ? 1.62153   -14.01148 14.94002  1.000 61.33808  ? 266 THR A CA  1 
ATOM   2121 C  C   . THR A 1 267 ? 0.19847   -14.54955 14.84939  1.000 58.24118  ? 266 THR A C   1 
ATOM   2122 O  O   . THR A 1 267 ? -0.00747  -15.71843 14.50065  1.000 61.61903  ? 266 THR A O   1 
ATOM   2123 C  CB  . THR A 1 267 ? 2.17783   -14.21656 16.35241  1.000 71.24335  ? 266 THR A CB  1 
ATOM   2124 O  OG1 . THR A 1 267 ? 3.52120   -13.72718 16.41241  1.000 80.96068  ? 266 THR A OG1 1 
ATOM   2125 C  CG2 . THR A 1 267 ? 2.18451   -15.68723 16.72944  1.000 69.93613  ? 266 THR A CG2 1 
ATOM   2126 N  N   . SER A 1 268 ? -0.79481  -13.70761 15.13951  1.000 65.80702  ? 267 SER A N   1 
ATOM   2127 C  CA  . SER A 1 268 ? -2.18767  -14.13748 15.12683  1.000 64.79273  ? 267 SER A CA  1 
ATOM   2128 C  C   . SER A 1 268 ? -2.71092  -14.41876 13.72147  1.000 64.25720  ? 267 SER A C   1 
ATOM   2129 O  O   . SER A 1 268 ? -3.71121  -15.13186 13.58136  1.000 61.71361  ? 267 SER A O   1 
ATOM   2130 C  CB  . SER A 1 268 ? -3.06658  -13.07551 15.79540  1.000 68.78303  ? 267 SER A CB  1 
ATOM   2131 O  OG  . SER A 1 268 ? -4.41963  -13.21484 15.40553  1.000 74.89588  ? 267 SER A OG  1 
ATOM   2132 N  N   . ILE A 1 269 ? -2.05954  -13.89386 12.68143  1.000 70.47361  ? 268 ILE A N   1 
ATOM   2133 C  CA  . ILE A 1 269 ? -2.57767  -13.98201 11.32062  1.000 62.93234  ? 268 ILE A CA  1 
ATOM   2134 C  C   . ILE A 1 269 ? -1.57893  -14.61480 10.35815  1.000 54.61844  ? 268 ILE A C   1 
ATOM   2135 O  O   . ILE A 1 269 ? -1.87070  -14.72307 9.16746   1.000 55.99349  ? 268 ILE A O   1 
ATOM   2136 C  CB  . ILE A 1 269 ? -3.01876  -12.60007 10.80702  1.000 60.34638  ? 268 ILE A CB  1 
ATOM   2137 C  CG1 . ILE A 1 269 ? -1.81661  -11.65540 10.74030  1.000 55.91544  ? 268 ILE A CG1 1 
ATOM   2138 C  CG2 . ILE A 1 269 ? -4.09445  -12.01644 11.70147  1.000 57.55565  ? 268 ILE A CG2 1 
ATOM   2139 C  CD1 . ILE A 1 269 ? -2.08589  -10.35121 10.04368  1.000 62.66966  ? 268 ILE A CD1 1 
ATOM   2140 N  N   . CYS A 1 270 ? -0.41679  -15.05082 10.83663  1.000 55.25698  ? 269 CYS A N   1 
ATOM   2141 C  CA  . CYS A 1 270 ? 0.58909   -15.65406 9.96745   1.000 56.04995  ? 269 CYS A CA  1 
ATOM   2142 C  C   . CYS A 1 270 ? 0.44512   -17.16982 9.99398   1.000 60.82730  ? 269 CYS A C   1 
ATOM   2143 O  O   . CYS A 1 270 ? 0.56360   -17.79340 11.05371  1.000 59.51738  ? 269 CYS A O   1 
ATOM   2144 C  CB  . CYS A 1 270 ? 2.00758   -15.24714 10.36650  1.000 53.86085  ? 269 CYS A CB  1 
ATOM   2145 S  SG  . CYS A 1 270 ? 3.29306   -15.98067 9.30056   1.000 55.13256  ? 269 CYS A SG  1 
ATOM   2146 N  N   . ASP A 1 271 ? 0.20999   -17.75332 8.81736   1.000 53.24810  ? 270 ASP A N   1 
ATOM   2147 C  CA  . ASP A 1 271 ? -0.00944  -19.18800 8.69684   1.000 52.01259  ? 270 ASP A CA  1 
ATOM   2148 C  C   . ASP A 1 271 ? 1.23202   -20.01083 9.01740   1.000 55.64456  ? 270 ASP A C   1 
ATOM   2149 O  O   . ASP A 1 271 ? 1.10575   -21.21001 9.28976   1.000 59.60977  ? 270 ASP A O   1 
ATOM   2150 C  CB  . ASP A 1 271 ? -0.50110  -19.51470 7.28830   1.000 51.98699  ? 270 ASP A CB  1 
ATOM   2151 C  CG  . ASP A 1 271 ? -1.95543  -19.14023 7.08170   1.000 55.24751  ? 270 ASP A CG  1 
ATOM   2152 O  OD1 . ASP A 1 271 ? -2.57065  -18.57461 8.01395   1.000 62.88928  ? 270 ASP A OD1 1 
ATOM   2153 O  OD2 . ASP A 1 271 ? -2.49427  -19.41812 5.99150   1.000 55.09712  ? 270 ASP A OD2 1 
ATOM   2154 N  N   . TYR A 1 272 ? 2.42033   -19.40778 8.99768   1.000 55.54222  ? 271 TYR A N   1 
ATOM   2155 C  CA  . TYR A 1 272 ? 3.65155   -20.11951 9.31632   1.000 57.36620  ? 271 TYR A CA  1 
ATOM   2156 C  C   . TYR A 1 272 ? 4.17729   -19.76688 10.69815  1.000 54.00117  ? 271 TYR A C   1 
ATOM   2157 O  O   . TYR A 1 272 ? 5.33047   -20.07986 11.01090  1.000 55.59667  ? 271 TYR A O   1 
ATOM   2158 C  CB  . TYR A 1 272 ? 4.72830   -19.83831 8.26568   1.000 58.85756  ? 271 TYR A CB  1 
ATOM   2159 C  CG  . TYR A 1 272 ? 4.41218   -20.41186 6.90447   1.000 60.48452  ? 271 TYR A CG  1 
ATOM   2160 C  CD1 . TYR A 1 272 ? 3.52905   -19.76894 6.05293   1.000 50.77169  ? 271 TYR A CD1 1 
ATOM   2161 C  CD2 . TYR A 1 272 ? 4.98922   -21.59917 6.47199   1.000 56.24797  ? 271 TYR A CD2 1 
ATOM   2162 C  CE1 . TYR A 1 272 ? 3.22701   -20.28859 4.81092   1.000 61.09885  ? 271 TYR A CE1 1 
ATOM   2163 C  CE2 . TYR A 1 272 ? 4.69257   -22.12513 5.22702   1.000 58.39050  ? 271 TYR A CE2 1 
ATOM   2164 C  CZ  . TYR A 1 272 ? 3.81275   -21.46548 4.40295   1.000 60.84498  ? 271 TYR A CZ  1 
ATOM   2165 O  OH  . TYR A 1 272 ? 3.51697   -21.98984 3.16854   1.000 59.32540  ? 271 TYR A OH  1 
ATOM   2166 N  N   . ALA A 1 273 ? 3.36981   -19.10605 11.52287  1.000 56.93350  ? 272 ALA A N   1 
ATOM   2167 C  CA  . ALA A 1 273 ? 3.80017   -18.75600 12.86846  1.000 68.93192  ? 272 ALA A CA  1 
ATOM   2168 C  C   . ALA A 1 273 ? 4.12330   -20.01261 13.66300  1.000 63.47537  ? 272 ALA A C   1 
ATOM   2169 O  O   . ALA A 1 273 ? 3.34854   -20.97279 13.67063  1.000 65.64310  ? 272 ALA A O   1 
ATOM   2170 C  CB  . ALA A 1 273 ? 2.71044   -17.94930 13.57446  1.000 60.03162  ? 272 ALA A CB  1 
ATOM   2171 N  N   . ASN A 1 274 ? 5.27948   -20.01179 14.31879  1.000 66.91262  ? 273 ASN A N   1 
ATOM   2172 C  CA  . ASN A 1 274 ? 5.62238   -21.08775 15.23836  1.000 87.09590  ? 273 ASN A CA  1 
ATOM   2173 C  C   . ASN A 1 274 ? 4.89385   -20.83975 16.55299  1.000 89.17717  ? 273 ASN A C   1 
ATOM   2174 O  O   . ASN A 1 274 ? 5.08052   -19.79529 17.18880  1.000 78.19126  ? 273 ASN A O   1 
ATOM   2175 C  CB  . ASN A 1 274 ? 7.13422   -21.16672 15.45036  1.000 82.89893  ? 273 ASN A CB  1 
ATOM   2176 C  CG  . ASN A 1 274 ? 7.57930   -22.49239 16.06519  1.000 89.40292  ? 273 ASN A CG  1 
ATOM   2177 O  OD1 . ASN A 1 274 ? 6.77472   -23.40498 16.25547  1.000 93.39319  ? 273 ASN A OD1 1 
ATOM   2178 N  ND2 . ASN A 1 274 ? 8.87217   -22.60427 16.36281  1.000 91.47104  ? 273 ASN A ND2 1 
ATOM   2179 N  N   . LYS A 1 275 ? 4.04982   -21.78719 16.94764  1.000 91.63986  ? 274 LYS A N   1 
ATOM   2180 C  CA  . LYS A 1 275 ? 3.22699   -21.65361 18.13915  1.000 94.68548  ? 274 LYS A CA  1 
ATOM   2181 C  C   . LYS A 1 275 ? 3.78764   -22.42153 19.32635  1.000 101.21549 ? 274 LYS A C   1 
ATOM   2182 O  O   . LYS A 1 275 ? 3.16853   -22.41992 20.39554  1.000 110.47272 ? 274 LYS A O   1 
ATOM   2183 C  CB  . LYS A 1 275 ? 1.79879   -22.11981 17.83889  1.000 93.04231  ? 274 LYS A CB  1 
ATOM   2184 C  CG  . LYS A 1 275 ? 1.09224   -21.31246 16.76266  1.000 81.56903  ? 274 LYS A CG  1 
ATOM   2185 C  CD  . LYS A 1 275 ? 0.58070   -19.98862 17.30370  1.000 77.46183  ? 274 LYS A CD  1 
ATOM   2186 C  CE  . LYS A 1 275 ? -0.24047  -19.25812 16.25472  1.000 70.82957  ? 274 LYS A CE  1 
ATOM   2187 N  NZ  . LYS A 1 275 ? -0.86896  -18.02084 16.79391  1.000 56.13681  ? 274 LYS A NZ  1 
ATOM   2188 N  N   . GLU A 1 276 ? 4.93396   -23.07715 19.15598  1.000 100.38206 ? 275 GLU A N   1 
ATOM   2189 C  CA  . GLU A 1 276 ? 5.55205   -23.90573 20.18769  1.000 103.60485 ? 275 GLU A CA  1 
ATOM   2190 C  C   . GLU A 1 276 ? 5.61755   -23.21586 21.54591  1.000 104.68030 ? 275 GLU A C   1 
ATOM   2191 O  O   . GLU A 1 276 ? 6.41603   -23.58710 22.40651  1.000 107.72927 ? 275 GLU A O   1 
ATOM   2192 C  CB  . GLU A 1 276 ? 6.96236   -24.31061 19.75356  1.000 105.13476 ? 275 GLU A CB  1 
ATOM   2193 C  CG  . GLU A 1 276 ? 7.91892   -23.13669 19.61236  1.000 106.29290 ? 275 GLU A CG  1 
ATOM   2194 C  CD  . GLU A 1 276 ? 9.36090   -23.56903 19.44211  1.000 107.41039 ? 275 GLU A CD  1 
ATOM   2195 O  OE1 . GLU A 1 276 ? 9.62463   -24.44443 18.59162  1.000 107.69616 ? 275 GLU A OE1 1 
ATOM   2196 O  OE2 . GLU A 1 276 ? 10.23469  -23.03146 20.15351  1.000 102.18498 ? 275 GLU A OE2 1 
ATOM   2197 N  N   . LYS B 1 8   ? -37.31545 19.19156  -6.88191  1.000 74.40490  ? 7   LYS B N   1 
ATOM   2198 C  CA  . LYS B 1 8   ? -37.31905 17.75193  -7.06556  1.000 91.86464  ? 7   LYS B CA  1 
ATOM   2199 C  C   . LYS B 1 8   ? -36.12270 17.14575  -6.35095  1.000 95.18164  ? 7   LYS B C   1 
ATOM   2200 O  O   . LYS B 1 8   ? -34.97696 17.29385  -6.78616  1.000 83.55589  ? 7   LYS B O   1 
ATOM   2201 C  CB  . LYS B 1 8   ? -37.29849 17.41836  -8.54855  1.000 84.13536  ? 7   LYS B CB  1 
ATOM   2202 N  N   . LYS B 1 9   ? -36.39849 16.47322  -5.23340  1.000 89.84255  ? 8   LYS B N   1 
ATOM   2203 C  CA  . LYS B 1 9   ? -35.34902 15.87815  -4.41633  1.000 86.50543  ? 8   LYS B CA  1 
ATOM   2204 C  C   . LYS B 1 9   ? -35.19286 14.41678  -4.80267  1.000 82.75804  ? 8   LYS B C   1 
ATOM   2205 O  O   . LYS B 1 9   ? -36.10263 13.61352  -4.54038  1.000 79.08812  ? 8   LYS B O   1 
ATOM   2206 C  CB  . LYS B 1 9   ? -35.68160 16.00540  -2.93832  1.000 75.65202  ? 8   LYS B CB  1 
ATOM   2207 N  N   . PRO B 1 10  ? -34.08800 14.02619  -5.43932  1.000 73.43290  ? 9   PRO B N   1 
ATOM   2208 C  CA  . PRO B 1 10  ? -33.94806 12.64868  -5.91945  1.000 79.89520  ? 9   PRO B CA  1 
ATOM   2209 C  C   . PRO B 1 10  ? -33.76279 11.67377  -4.76805  1.000 80.91849  ? 9   PRO B C   1 
ATOM   2210 O  O   . PRO B 1 10  ? -33.30933 12.04055  -3.68076  1.000 75.24056  ? 9   PRO B O   1 
ATOM   2211 C  CB  . PRO B 1 10  ? -32.69149 12.70629  -6.80109  1.000 78.49318  ? 9   PRO B CB  1 
ATOM   2212 C  CG  . PRO B 1 10  ? -32.39594 14.18156  -6.99887  1.000 79.91205  ? 9   PRO B CG  1 
ATOM   2213 C  CD  . PRO B 1 10  ? -32.90519 14.84196  -5.75776  1.000 79.05295  ? 9   PRO B CD  1 
ATOM   2214 N  N   . TRP B 1 11  ? -34.11794 10.41583  -5.01929  1.000 83.60791  ? 10  TRP B N   1 
ATOM   2215 C  CA  . TRP B 1 11  ? -33.86922 9.34592   -4.06514  1.000 73.79949  ? 10  TRP B CA  1 
ATOM   2216 C  C   . TRP B 1 11  ? -32.53286 8.68688   -4.37624  1.000 70.35793  ? 10  TRP B C   1 
ATOM   2217 O  O   . TRP B 1 11  ? -32.17165 8.51218   -5.54279  1.000 67.89681  ? 10  TRP B O   1 
ATOM   2218 C  CB  . TRP B 1 11  ? -34.98661 8.30075   -4.09920  1.000 70.05989  ? 10  TRP B CB  1 
ATOM   2219 C  CG  . TRP B 1 11  ? -34.76886 7.18686   -3.11875  1.000 70.97638  ? 10  TRP B CG  1 
ATOM   2220 C  CD1 . TRP B 1 11  ? -35.17255 7.15234   -1.81752  1.000 69.10906  ? 10  TRP B CD1 1 
ATOM   2221 C  CD2 . TRP B 1 11  ? -34.07656 5.95359   -3.35702  1.000 65.96751  ? 10  TRP B CD2 1 
ATOM   2222 N  NE1 . TRP B 1 11  ? -34.77991 5.97295   -1.23051  1.000 59.99576  ? 10  TRP B NE1 1 
ATOM   2223 C  CE2 . TRP B 1 11  ? -34.10444 5.21963   -2.15423  1.000 63.97564  ? 10  TRP B CE2 1 
ATOM   2224 C  CE3 . TRP B 1 11  ? -33.43810 5.39922   -4.47087  1.000 62.69809  ? 10  TRP B CE3 1 
ATOM   2225 C  CZ2 . TRP B 1 11  ? -33.51962 3.95891   -2.03429  1.000 62.89585  ? 10  TRP B CZ2 1 
ATOM   2226 C  CZ3 . TRP B 1 11  ? -32.85839 4.14939   -4.35055  1.000 60.81749  ? 10  TRP B CZ3 1 
ATOM   2227 C  CH2 . TRP B 1 11  ? -32.90336 3.44269   -3.14151  1.000 60.73723  ? 10  TRP B CH2 1 
ATOM   2228 N  N   . TYR B 1 12  ? -31.79997 8.32831   -3.32711  1.000 66.04503  ? 11  TYR B N   1 
ATOM   2229 C  CA  . TYR B 1 12  ? -30.52122 7.64004   -3.44403  1.000 68.28474  ? 11  TYR B CA  1 
ATOM   2230 C  C   . TYR B 1 12  ? -30.45724 6.52319   -2.42248  1.000 67.34926  ? 11  TYR B C   1 
ATOM   2231 O  O   . TYR B 1 12  ? -31.07310 6.61884   -1.34941  1.000 61.73328  ? 11  TYR B O   1 
ATOM   2232 C  CB  . TYR B 1 12  ? -29.34085 8.60973   -3.25265  1.000 65.16082  ? 11  TYR B CB  1 
ATOM   2233 C  CG  . TYR B 1 12  ? -29.24802 9.67265   -4.32944  1.000 71.00152  ? 11  TYR B CG  1 
ATOM   2234 C  CD1 . TYR B 1 12  ? -28.68949 9.38638   -5.56930  1.000 71.32736  ? 11  TYR B CD1 1 
ATOM   2235 C  CD2 . TYR B 1 12  ? -29.71773 10.95966  -4.10530  1.000 69.08034  ? 11  TYR B CD2 1 
ATOM   2236 C  CE1 . TYR B 1 12  ? -28.60319 10.35302  -6.55675  1.000 70.47455  ? 11  TYR B CE1 1 
ATOM   2237 C  CE2 . TYR B 1 12  ? -29.63615 11.92835  -5.08293  1.000 70.23443  ? 11  TYR B CE2 1 
ATOM   2238 C  CZ  . TYR B 1 12  ? -29.07787 11.62156  -6.30764  1.000 68.87015  ? 11  TYR B CZ  1 
ATOM   2239 O  OH  . TYR B 1 12  ? -28.99598 12.58617  -7.28199  1.000 67.44397  ? 11  TYR B OH  1 
ATOM   2240 N  N   . PRO B 1 13  ? -29.75572 5.42960   -2.72176  1.000 64.37942  ? 12  PRO B N   1 
ATOM   2241 C  CA  . PRO B 1 13  ? -29.68362 4.28927   -1.79342  1.000 56.62765  ? 12  PRO B CA  1 
ATOM   2242 C  C   . PRO B 1 13  ? -29.11436 4.70139   -0.44511  1.000 59.67007  ? 12  PRO B C   1 
ATOM   2243 O  O   . PRO B 1 13  ? -28.06239 5.35680   -0.37270  1.000 56.85894  ? 12  PRO B O   1 
ATOM   2244 C  CB  . PRO B 1 13  ? -28.75931 3.30286   -2.52227  1.000 53.08974  ? 12  PRO B CB  1 
ATOM   2245 C  CG  . PRO B 1 13  ? -28.90235 3.66766   -3.96723  1.000 63.47373  ? 12  PRO B CG  1 
ATOM   2246 C  CD  . PRO B 1 13  ? -29.04470 5.15600   -3.98542  1.000 57.09468  ? 12  PRO B CD  1 
ATOM   2247 N  N   . PRO B 1 14  ? -29.78208 4.33755   0.64877   1.000 61.04374  ? 13  PRO B N   1 
ATOM   2248 C  CA  . PRO B 1 14  ? -29.34176 4.77383   1.97987   1.000 61.13611  ? 13  PRO B CA  1 
ATOM   2249 C  C   . PRO B 1 14  ? -28.10421 4.03523   2.46451   1.000 56.11386  ? 13  PRO B C   1 
ATOM   2250 O  O   . PRO B 1 14  ? -27.84750 2.88679   2.09643   1.000 55.26124  ? 13  PRO B O   1 
ATOM   2251 C  CB  . PRO B 1 14  ? -30.54410 4.44606   2.87865   1.000 56.53063  ? 13  PRO B CB  1 
ATOM   2252 C  CG  . PRO B 1 14  ? -31.68287 4.16457   1.94854   1.000 63.55937  ? 13  PRO B CG  1 
ATOM   2253 C  CD  . PRO B 1 14  ? -31.06895 3.62737   0.70094   1.000 62.75382  ? 13  PRO B CD  1 
ATOM   2254 N  N   . MET B 1 15  ? -27.33789 4.71693   3.31587   1.000 51.03167  ? 14  MET B N   1 
ATOM   2255 C  CA  . MET B 1 15  ? -26.19981 4.09896   3.98172   1.000 46.79758  ? 14  MET B CA  1 
ATOM   2256 C  C   . MET B 1 15  ? -25.94911 4.79930   5.30896   1.000 54.10472  ? 14  MET B C   1 
ATOM   2257 O  O   . MET B 1 15  ? -26.01939 6.02887   5.39492   1.000 49.72453  ? 14  MET B O   1 
ATOM   2258 C  CB  . MET B 1 15  ? -24.93669 4.14764   3.11763   1.000 47.09720  ? 14  MET B CB  1 
ATOM   2259 C  CG  . MET B 1 15  ? -23.69390 3.62571   3.82771   1.000 50.35642  ? 14  MET B CG  1 
ATOM   2260 S  SD  . MET B 1 15  ? -23.90296 1.97353   4.54542   1.000 50.78629  ? 14  MET B SD  1 
ATOM   2261 C  CE  . MET B 1 15  ? -24.05122 0.98447   3.06304   1.000 49.04903  ? 14  MET B CE  1 
ATOM   2262 N  N   . SER B 1 16  ? -25.65965 4.00346   6.33736   1.000 51.43621  ? 15  SER B N   1 
ATOM   2263 C  CA  . SER B 1 16  ? -25.36361 4.49864   7.67402   1.000 49.09974  ? 15  SER B CA  1 
ATOM   2264 C  C   . SER B 1 16  ? -24.38970 3.53605   8.34148   1.000 51.92800  ? 15  SER B C   1 
ATOM   2265 O  O   . SER B 1 16  ? -24.14865 2.42969   7.84714   1.000 50.49088  ? 15  SER B O   1 
ATOM   2266 C  CB  . SER B 1 16  ? -26.63868 4.64018   8.51249   1.000 51.79696  ? 15  SER B CB  1 
ATOM   2267 O  OG  . SER B 1 16  ? -27.17618 3.36915   8.84519   1.000 49.83391  ? 15  SER B OG  1 
ATOM   2268 N  N   . TYR B 1 17  ? -23.80758 3.96651   9.46923   1.000 45.82110  ? 16  TYR B N   1 
ATOM   2269 C  CA  . TYR B 1 17  ? -22.97143 3.05176   10.24214  1.000 53.21069  ? 16  TYR B CA  1 
ATOM   2270 C  C   . TYR B 1 17  ? -23.78585 1.86844   10.74634  1.000 47.66528  ? 16  TYR B C   1 
ATOM   2271 O  O   . TYR B 1 17  ? -23.29686 0.73233   10.77186  1.000 52.84751  ? 16  TYR B O   1 
ATOM   2272 C  CB  . TYR B 1 17  ? -22.31164 3.76869   11.41748  1.000 50.92408  ? 16  TYR B CB  1 
ATOM   2273 C  CG  . TYR B 1 17  ? -21.76841 2.78921   12.42884  1.000 54.82608  ? 16  TYR B CG  1 
ATOM   2274 C  CD1 . TYR B 1 17  ? -20.70626 1.95847   12.10794  1.000 52.76498  ? 16  TYR B CD1 1 
ATOM   2275 C  CD2 . TYR B 1 17  ? -22.33851 2.66567   13.68594  1.000 50.98988  ? 16  TYR B CD2 1 
ATOM   2276 C  CE1 . TYR B 1 17  ? -20.21485 1.04465   13.01235  1.000 58.02713  ? 16  TYR B CE1 1 
ATOM   2277 C  CE2 . TYR B 1 17  ? -21.85048 1.75326   14.60244  1.000 56.64018  ? 16  TYR B CE2 1 
ATOM   2278 C  CZ  . TYR B 1 17  ? -20.78818 0.94449   14.26079  1.000 62.09805  ? 16  TYR B CZ  1 
ATOM   2279 O  OH  . TYR B 1 17  ? -20.29955 0.03530   15.16995  1.000 53.43035  ? 16  TYR B OH  1 
ATOM   2280 N  N   . SER B 1 18  ? -25.03185 2.11821   11.15899  1.000 48.85718  ? 17  SER B N   1 
ATOM   2281 C  CA  . SER B 1 18  ? -25.90237 1.02290   11.56803  1.000 53.20768  ? 17  SER B CA  1 
ATOM   2282 C  C   . SER B 1 18  ? -26.09767 0.03188   10.42695  1.000 55.05746  ? 17  SER B C   1 
ATOM   2283 O  O   . SER B 1 18  ? -26.06572 -1.18716  10.63888  1.000 52.50831  ? 17  SER B O   1 
ATOM   2284 C  CB  . SER B 1 18  ? -27.24267 1.57651   12.04540  1.000 48.45117  ? 17  SER B CB  1 
ATOM   2285 O  OG  . SER B 1 18  ? -27.06287 2.45840   13.13677  1.000 73.38507  ? 17  SER B OG  1 
ATOM   2286 N  N   . LEU B 1 19  ? -26.27857 0.53908   9.20278   1.000 52.48595  ? 18  LEU B N   1 
ATOM   2287 C  CA  . LEU B 1 19  ? -26.39876 -0.34056  8.04216   1.000 54.62070  ? 18  LEU B CA  1 
ATOM   2288 C  C   . LEU B 1 19  ? -25.09202 -1.07601  7.76960   1.000 52.52920  ? 18  LEU B C   1 
ATOM   2289 O  O   . LEU B 1 19  ? -25.09267 -2.27973  7.47207   1.000 54.83743  ? 18  LEU B O   1 
ATOM   2290 C  CB  . LEU B 1 19  ? -26.82866 0.46598   6.81581   1.000 51.57632  ? 18  LEU B CB  1 
ATOM   2291 C  CG  . LEU B 1 19  ? -27.49731 -0.30945  5.67439   1.000 51.41476  ? 18  LEU B CG  1 
ATOM   2292 C  CD1 . LEU B 1 19  ? -28.76746 -0.96143  6.17295   1.000 58.59816  ? 18  LEU B CD1 1 
ATOM   2293 C  CD2 . LEU B 1 19  ? -27.79472 0.57248   4.46945   1.000 51.66549  ? 18  LEU B CD2 1 
ATOM   2294 N  N   . TRP B 1 20  ? -23.96637 -0.36376  7.87797   1.000 50.30646  ? 19  TRP B N   1 
ATOM   2295 C  CA  . TRP B 1 20  ? -22.66094 -0.97335  7.64907   1.000 51.50803  ? 19  TRP B CA  1 
ATOM   2296 C  C   . TRP B 1 20  ? -22.42538 -2.13784  8.60406   1.000 56.08818  ? 19  TRP B C   1 
ATOM   2297 O  O   . TRP B 1 20  ? -21.95780 -3.20726  8.19091   1.000 55.56707  ? 19  TRP B O   1 
ATOM   2298 C  CB  . TRP B 1 20  ? -21.57101 0.09104   7.80266   1.000 53.58960  ? 19  TRP B CB  1 
ATOM   2299 C  CG  . TRP B 1 20  ? -20.17806 -0.32807  7.41233   1.000 49.47669  ? 19  TRP B CG  1 
ATOM   2300 C  CD1 . TRP B 1 20  ? -19.77055 -1.56179  7.00327   1.000 58.93471  ? 19  TRP B CD1 1 
ATOM   2301 C  CD2 . TRP B 1 20  ? -19.00705 0.50141   7.40128   1.000 56.02648  ? 19  TRP B CD2 1 
ATOM   2302 N  NE1 . TRP B 1 20  ? -18.42608 -1.55236  6.72874   1.000 61.10962  ? 19  TRP B NE1 1 
ATOM   2303 C  CE2 . TRP B 1 20  ? -17.93208 -0.29873  6.96911   1.000 56.83363  ? 19  TRP B CE2 1 
ATOM   2304 C  CE3 . TRP B 1 20  ? -18.76468 1.84138   7.71635   1.000 45.61375  ? 19  TRP B CE3 1 
ATOM   2305 C  CZ2 . TRP B 1 20  ? -16.63626 0.19521   6.84252   1.000 57.27943  ? 19  TRP B CZ2 1 
ATOM   2306 C  CZ3 . TRP B 1 20  ? -17.47759 2.33086   7.58889   1.000 41.82829  ? 19  TRP B CZ3 1 
ATOM   2307 C  CH2 . TRP B 1 20  ? -16.43048 1.51099   7.15628   1.000 51.10754  ? 19  TRP B CH2 1 
ATOM   2308 N  N   . ARG B 1 21  ? -22.76142 -1.95483  9.88375   1.000 53.60341  ? 20  ARG B N   1 
ATOM   2309 C  CA  . ARG B 1 21  ? -22.54969 -3.01231  10.86321  1.000 55.11797  ? 20  ARG B CA  1 
ATOM   2310 C  C   . ARG B 1 21  ? -23.57831 -4.13090  10.71949  1.000 56.42461  ? 20  ARG B C   1 
ATOM   2311 O  O   . ARG B 1 21  ? -23.24327 -5.30191  10.93593  1.000 55.99110  ? 20  ARG B O   1 
ATOM   2312 C  CB  . ARG B 1 21  ? -22.56782 -2.43432  12.28308  1.000 61.19464  ? 20  ARG B CB  1 
ATOM   2313 C  CG  . ARG B 1 21  ? -23.93793 -2.02669  12.81026  1.000 60.34673  ? 20  ARG B CG  1 
ATOM   2314 C  CD  . ARG B 1 21  ? -23.85504 -1.52445  14.23965  1.000 67.86115  ? 20  ARG B CD  1 
ATOM   2315 N  NE  . ARG B 1 21  ? -23.27247 -2.52062  15.13068  1.000 66.95850  ? 20  ARG B NE  1 
ATOM   2316 C  CZ  . ARG B 1 21  ? -23.02761 -2.32007  16.41898  1.000 80.73560  ? 20  ARG B CZ  1 
ATOM   2317 N  NH1 . ARG B 1 21  ? -23.29536 -1.16211  17.00349  1.000 85.57805  ? 20  ARG B NH1 1 
ATOM   2318 N  NH2 . ARG B 1 21  ? -22.50164 -3.30558  17.14073  1.000 81.70319  ? 20  ARG B NH2 1 
ATOM   2319 N  N   . SER B 1 22  ? -24.82165 -3.80453  10.33943  1.000 50.45740  ? 21  SER B N   1 
ATOM   2320 C  CA  . SER B 1 22  ? -25.81964 -4.83843  10.09895  1.000 54.53180  ? 21  SER B CA  1 
ATOM   2321 C  C   . SER B 1 22  ? -25.49705 -5.65859  8.85887   1.000 55.71418  ? 21  SER B C   1 
ATOM   2322 O  O   . SER B 1 22  ? -25.98941 -6.78417  8.72791   1.000 61.06084  ? 21  SER B O   1 
ATOM   2323 C  CB  . SER B 1 22  ? -27.20401 -4.20829  9.96422   1.000 50.56841  ? 21  SER B CB  1 
ATOM   2324 O  OG  . SER B 1 22  ? -27.26387 -3.35545  8.83556   1.000 64.23197  ? 21  SER B OG  1 
ATOM   2325 N  N   . LEU B 1 23  ? -24.67649 -5.12374  7.95468   1.000 56.16035  ? 22  LEU B N   1 
ATOM   2326 C  CA  . LEU B 1 23  ? -24.27728 -5.83027  6.74460   1.000 60.96479  ? 22  LEU B CA  1 
ATOM   2327 C  C   . LEU B 1 23  ? -22.98114 -6.61133  6.90873   1.000 58.11669  ? 22  LEU B C   1 
ATOM   2328 O  O   . LEU B 1 23  ? -22.86528 -7.71972  6.37619   1.000 59.40334  ? 22  LEU B O   1 
ATOM   2329 C  CB  . LEU B 1 23  ? -24.13317 -4.84341  5.58394   1.000 52.25882  ? 22  LEU B CB  1 
ATOM   2330 C  CG  . LEU B 1 23  ? -25.43362 -4.42640  4.89791   1.000 47.82073  ? 22  LEU B CG  1 
ATOM   2331 C  CD1 . LEU B 1 23  ? -25.28856 -3.05019  4.26737   1.000 59.59356  ? 22  LEU B CD1 1 
ATOM   2332 C  CD2 . LEU B 1 23  ? -25.81492 -5.45401  3.84832   1.000 56.94930  ? 22  LEU B CD2 1 
ATOM   2333 N  N   . LYS B 1 24  ? -21.99830 -6.06371  7.62328   1.000 51.38292  ? 23  LYS B N   1 
ATOM   2334 C  CA  . LYS B 1 24  ? -20.74839 -6.76915  7.83616   1.000 54.43312  ? 23  LYS B CA  1 
ATOM   2335 C  C   . LYS B 1 24  ? -20.35453 -6.70043  9.30434   1.000 61.79980  ? 23  LYS B C   1 
ATOM   2336 O  O   . LYS B 1 24  ? -20.47096 -5.64294  9.93604   1.000 60.91366  ? 23  LYS B O   1 
ATOM   2337 C  CB  . LYS B 1 24  ? -19.61928 -6.19142  6.97247   1.000 59.21248  ? 23  LYS B CB  1 
ATOM   2338 C  CG  . LYS B 1 24  ? -19.66466 -6.63619  5.52243   1.000 64.04080  ? 23  LYS B CG  1 
ATOM   2339 C  CD  . LYS B 1 24  ? -18.46347 -6.12128  4.74061   1.000 58.44446  ? 23  LYS B CD  1 
ATOM   2340 C  CE  . LYS B 1 24  ? -17.15627 -6.66786  5.29805   1.000 64.12414  ? 23  LYS B CE  1 
ATOM   2341 N  NZ  . LYS B 1 24  ? -15.97194 -6.23031  4.49965   1.000 62.83115  ? 23  LYS B NZ  1 
ATOM   2342 N  N   . PRO B 1 25  ? -19.89720 -7.81043  9.87275   1.000 60.32672  ? 24  PRO B N   1 
ATOM   2343 C  CA  . PRO B 1 25  ? -19.45783 -7.80090  11.26834  1.000 59.96650  ? 24  PRO B CA  1 
ATOM   2344 C  C   . PRO B 1 25  ? -18.10050 -7.13922  11.42366  1.000 61.77507  ? 24  PRO B C   1 
ATOM   2345 O  O   . PRO B 1 25  ? -17.25681 -7.16668  10.52397  1.000 68.46344  ? 24  PRO B O   1 
ATOM   2346 C  CB  . PRO B 1 25  ? -19.38103 -9.29222  11.61680  1.000 63.99211  ? 24  PRO B CB  1 
ATOM   2347 C  CG  . PRO B 1 25  ? -19.02066 -9.93707  10.31326  1.000 62.76773  ? 24  PRO B CG  1 
ATOM   2348 C  CD  . PRO B 1 25  ? -19.71751 -9.13207  9.24547   1.000 54.83602  ? 24  PRO B CD  1 
ATOM   2349 N  N   . ALA B 1 26  ? -17.89568 -6.54693  12.59599  1.000 63.23505  ? 25  ALA B N   1 
ATOM   2350 C  CA  . ALA B 1 26  ? -16.56970 -6.07656  12.95343  1.000 64.55012  ? 25  ALA B CA  1 
ATOM   2351 C  C   . ALA B 1 26  ? -15.62528 -7.26527  13.09878  1.000 66.81645  ? 25  ALA B C   1 
ATOM   2352 O  O   . ALA B 1 26  ? -16.05028 -8.41220  13.25985  1.000 65.80166  ? 25  ALA B O   1 
ATOM   2353 C  CB  . ALA B 1 26  ? -16.61762 -5.27923  14.25439  1.000 63.45219  ? 25  ALA B CB  1 
ATOM   2354 N  N   . ILE B 1 27  ? -14.32585 -6.98660  13.03153  1.000 73.38800  ? 26  ILE B N   1 
ATOM   2355 C  CA  . ILE B 1 27  ? -13.33950 -8.05129  13.16696  1.000 73.40674  ? 26  ILE B CA  1 
ATOM   2356 C  C   . ILE B 1 27  ? -13.34195 -8.52577  14.61456  1.000 71.57785  ? 26  ILE B C   1 
ATOM   2357 O  O   . ILE B 1 27  ? -13.14576 -7.73221  15.54107  1.000 68.51280  ? 26  ILE B O   1 
ATOM   2358 C  CB  . ILE B 1 27  ? -11.94867 -7.57046  12.73427  1.000 77.10192  ? 26  ILE B CB  1 
ATOM   2359 C  CG1 . ILE B 1 27  ? -11.95708 -7.15438  11.25920  1.000 74.12606  ? 26  ILE B CG1 1 
ATOM   2360 C  CG2 . ILE B 1 27  ? -10.91218 -8.65379  12.97254  1.000 80.14683  ? 26  ILE B CG2 1 
ATOM   2361 C  CD1 . ILE B 1 27  ? -12.09645 -5.65711  11.03641  1.000 77.86848  ? 26  ILE B CD1 1 
ATOM   2362 N  N   . GLY B 1 28  ? -13.57793 -9.82099  14.81636  1.000 65.92521  ? 27  GLY B N   1 
ATOM   2363 C  CA  . GLY B 1 28  ? -13.64226 -10.40202 16.14029  1.000 72.01695  ? 27  GLY B CA  1 
ATOM   2364 C  C   . GLY B 1 28  ? -15.04139 -10.67724 16.64801  1.000 69.44765  ? 27  GLY B C   1 
ATOM   2365 O  O   . GLY B 1 28  ? -15.18656 -11.30138 17.70748  1.000 73.27225  ? 27  GLY B O   1 
ATOM   2366 N  N   . TYR B 1 29  ? -16.07031 -10.21630 15.93566  1.000 62.74696  ? 28  TYR B N   1 
ATOM   2367 C  CA  . TYR B 1 29  ? -17.45956 -10.41661 16.32813  1.000 62.94642  ? 28  TYR B CA  1 
ATOM   2368 C  C   . TYR B 1 29  ? -18.23662 -11.17383 15.25633  1.000 59.23036  ? 28  TYR B C   1 
ATOM   2369 O  O   . TYR B 1 29  ? -19.46555 -11.06156 15.18501  1.000 54.84287  ? 28  TYR B O   1 
ATOM   2370 C  CB  . TYR B 1 29  ? -18.11668 -9.06826  16.63543  1.000 58.95620  ? 28  TYR B CB  1 
ATOM   2371 C  CG  . TYR B 1 29  ? -17.45430 -8.31244  17.77564  1.000 66.03752  ? 28  TYR B CG  1 
ATOM   2372 C  CD1 . TYR B 1 29  ? -16.26434 -7.61758  17.58232  1.000 68.69572  ? 28  TYR B CD1 1 
ATOM   2373 C  CD2 . TYR B 1 29  ? -18.02501 -8.28997  19.04265  1.000 70.37355  ? 28  TYR B CD2 1 
ATOM   2374 C  CE1 . TYR B 1 29  ? -15.65985 -6.93330  18.61928  1.000 70.78770  ? 28  TYR B CE1 1 
ATOM   2375 C  CE2 . TYR B 1 29  ? -17.43047 -7.60733  20.08321  1.000 70.68308  ? 28  TYR B CE2 1 
ATOM   2376 C  CZ  . TYR B 1 29  ? -16.24783 -6.93003  19.86822  1.000 76.54078  ? 28  TYR B CZ  1 
ATOM   2377 O  OH  . TYR B 1 29  ? -15.64853 -6.24651  20.90461  1.000 90.97774  ? 28  TYR B OH  1 
ATOM   2378 N  N   . GLU B 1 30  ? -17.53232 -11.95476 14.42960  1.000 58.39473  ? 29  GLU B N   1 
ATOM   2379 C  CA  . GLU B 1 30  ? -18.15588 -12.60672 13.28197  1.000 61.85811  ? 29  GLU B CA  1 
ATOM   2380 C  C   . GLU B 1 30  ? -19.23652 -13.59378 13.71007  1.000 62.49972  ? 29  GLU B C   1 
ATOM   2381 O  O   . GLU B 1 30  ? -20.30491 -13.66280 13.09077  1.000 62.79204  ? 29  GLU B O   1 
ATOM   2382 C  CB  . GLU B 1 30  ? -17.08646 -13.31001 12.44314  1.000 63.16020  ? 29  GLU B CB  1 
ATOM   2383 C  CG  . GLU B 1 30  ? -16.02979 -12.37779 11.84661  1.000 63.92200  ? 29  GLU B CG  1 
ATOM   2384 C  CD  . GLU B 1 30  ? -14.79060 -12.24385 12.71405  1.000 68.16917  ? 29  GLU B CD  1 
ATOM   2385 O  OE1 . GLU B 1 30  ? -14.84214 -12.65399 13.89181  1.000 66.71566  ? 29  GLU B OE1 1 
ATOM   2386 O  OE2 . GLU B 1 30  ? -13.76038 -11.74152 12.21334  1.000 65.34677  ? 29  GLU B OE2 1 
ATOM   2387 N  N   . ASN B 1 31  ? -18.98315 -14.36476 14.76872  1.000 62.76410  ? 30  ASN B N   1 
ATOM   2388 C  CA  . ASN B 1 31  ? -19.93976 -15.38368 15.18656  1.000 63.66208  ? 30  ASN B CA  1 
ATOM   2389 C  C   . ASN B 1 31  ? -21.20395 -14.78998 15.79423  1.000 60.27973  ? 30  ASN B C   1 
ATOM   2390 O  O   . ASN B 1 31  ? -22.16503 -15.52934 16.03048  1.000 65.22307  ? 30  ASN B O   1 
ATOM   2391 C  CB  . ASN B 1 31  ? -19.27789 -16.34350 16.17970  1.000 67.55454  ? 30  ASN B CB  1 
ATOM   2392 C  CG  . ASN B 1 31  ? -19.86985 -17.74278 16.12850  1.000 67.77987  ? 30  ASN B CG  1 
ATOM   2393 O  OD1 . ASN B 1 31  ? -20.54444 -18.10563 15.16928  1.000 54.93181  ? 30  ASN B OD1 1 
ATOM   2394 N  ND2 . ASN B 1 31  ? -19.60902 -18.53836 17.16219  1.000 72.34474  ? 30  ASN B ND2 1 
ATOM   2395 N  N   . TRP B 1 32  ? -21.23209 -13.48162 16.03543  1.000 67.98198  ? 31  TRP B N   1 
ATOM   2396 C  CA  . TRP B 1 32  ? -22.38751 -12.82989 16.63739  1.000 68.26774  ? 31  TRP B CA  1 
ATOM   2397 C  C   . TRP B 1 32  ? -23.02046 -11.84728 15.65805  1.000 66.64339  ? 31  TRP B C   1 
ATOM   2398 O  O   . TRP B 1 32  ? -23.33717 -10.71290 16.03051  1.000 68.39885  ? 31  TRP B O   1 
ATOM   2399 C  CB  . TRP B 1 32  ? -21.99051 -12.08669 17.91447  1.000 65.84084  ? 31  TRP B CB  1 
ATOM   2400 C  CG  . TRP B 1 32  ? -21.50618 -12.94879 19.03209  1.000 75.62425  ? 31  TRP B CG  1 
ATOM   2401 C  CD1 . TRP B 1 32  ? -21.59918 -14.30199 19.12444  1.000 71.76875  ? 31  TRP B CD1 1 
ATOM   2402 C  CD2 . TRP B 1 32  ? -20.85377 -12.50621 20.22943  1.000 72.00537  ? 31  TRP B CD2 1 
ATOM   2403 N  NE1 . TRP B 1 32  ? -21.04419 -14.73361 20.30548  1.000 67.77187  ? 31  TRP B NE1 1 
ATOM   2404 C  CE2 . TRP B 1 32  ? -20.57751 -13.64987 21.00149  1.000 71.87575  ? 31  TRP B CE2 1 
ATOM   2405 C  CE3 . TRP B 1 32  ? -20.47602 -11.25313 20.72004  1.000 68.82509  ? 31  TRP B CE3 1 
ATOM   2406 C  CZ2 . TRP B 1 32  ? -19.94166 -13.57885 22.24054  1.000 70.33230  ? 31  TRP B CZ2 1 
ATOM   2407 C  CZ3 . TRP B 1 32  ? -19.84402 -11.18214 21.94708  1.000 68.94177  ? 31  TRP B CZ3 1 
ATOM   2408 C  CH2 . TRP B 1 32  ? -19.58292 -12.33692 22.69441  1.000 68.93158  ? 31  TRP B CH2 1 
ATOM   2409 N  N   . HIS B 1 33  ? -23.20756 -12.26554 14.40621  1.000 63.65283  ? 32  HIS B N   1 
ATOM   2410 C  CA  . HIS B 1 33  ? -23.72414 -11.39016 13.35636  1.000 57.88560  ? 32  HIS B CA  1 
ATOM   2411 C  C   . HIS B 1 33  ? -24.74490 -12.16946 12.53784  1.000 66.07214  ? 32  HIS B C   1 
ATOM   2412 O  O   . HIS B 1 33  ? -24.37346 -13.07893 11.79079  1.000 69.95994  ? 32  HIS B O   1 
ATOM   2413 C  CB  . HIS B 1 33  ? -22.59169 -10.87719 12.46826  1.000 59.00979  ? 32  HIS B CB  1 
ATOM   2414 C  CG  . HIS B 1 33  ? -23.02923 -9.84574  11.47860  1.000 64.45154  ? 32  HIS B CG  1 
ATOM   2415 N  ND1 . HIS B 1 33  ? -23.78275 -10.15237 10.36564  1.000 76.48163  ? 32  HIS B ND1 1 
ATOM   2416 C  CD2 . HIS B 1 33  ? -22.83276 -8.50760  11.44143  1.000 64.99440  ? 32  HIS B CD2 1 
ATOM   2417 C  CE1 . HIS B 1 33  ? -24.02518 -9.04935  9.68100   1.000 60.03472  ? 32  HIS B CE1 1 
ATOM   2418 N  NE2 . HIS B 1 33  ? -23.45832 -8.03703  10.31186  1.000 66.20270  ? 32  HIS B NE2 1 
ATOM   2419 N  N   . CYS B 1 34  ? -26.02370 -11.82139 12.66904  1.000 64.56517  ? 33  CYS B N   1 
ATOM   2420 C  CA  . CYS B 1 34  ? -27.09844 -12.51176 11.96107  1.000 64.18092  ? 33  CYS B CA  1 
ATOM   2421 C  C   . CYS B 1 34  ? -27.71465 -11.60008 10.90118  1.000 60.79391  ? 33  CYS B C   1 
ATOM   2422 O  O   . CYS B 1 34  ? -28.23225 -10.52363 11.22351  1.000 58.42873  ? 33  CYS B O   1 
ATOM   2423 C  CB  . CYS B 1 34  ? -28.16926 -12.99661 12.93847  1.000 56.63054  ? 33  CYS B CB  1 
ATOM   2424 S  SG  . CYS B 1 34  ? -29.67539 -13.58294 12.13950  1.000 62.82319  ? 33  CYS B SG  1 
ATOM   2425 N  N   . GLN B 1 35  ? -27.68295 -12.05206 9.64153   1.000 59.75629  ? 34  GLN B N   1 
ATOM   2426 C  CA  . GLN B 1 35  ? -28.28096 -11.29981 8.54115   1.000 53.51533  ? 34  GLN B CA  1 
ATOM   2427 C  C   . GLN B 1 35  ? -29.80554 -11.27084 8.60397   1.000 49.70389  ? 34  GLN B C   1 
ATOM   2428 O  O   . GLN B 1 35  ? -30.41835 -10.32620 8.09071   1.000 41.73980  ? 34  GLN B O   1 
ATOM   2429 C  CB  . GLN B 1 35  ? -27.82791 -11.88922 7.20541   1.000 50.33505  ? 34  GLN B CB  1 
ATOM   2430 C  CG  . GLN B 1 35  ? -26.32314 -11.97674 7.05860   1.000 52.85064  ? 34  GLN B CG  1 
ATOM   2431 C  CD  . GLN B 1 35  ? -25.90131 -12.36095 5.66344   1.000 68.99318  ? 34  GLN B CD  1 
ATOM   2432 O  OE1 . GLN B 1 35  ? -26.38014 -11.80036 4.67620   1.000 72.63710  ? 34  GLN B OE1 1 
ATOM   2433 N  NE2 . GLN B 1 35  ? -25.00105 -13.32878 5.57048   1.000 67.06667  ? 34  GLN B NE2 1 
ATOM   2434 N  N   . THR B 1 36  ? -30.43201 -12.28025 9.21493   1.000 54.49395  ? 35  THR B N   1 
ATOM   2435 C  CA  . THR B 1 36  ? -31.87924 -12.24303 9.40094   1.000 55.64442  ? 35  THR B CA  1 
ATOM   2436 C  C   . THR B 1 36  ? -32.28735 -11.08140 10.29595  1.000 56.75014  ? 35  THR B C   1 
ATOM   2437 O  O   . THR B 1 36  ? -33.40314 -10.56291 10.17420  1.000 57.12238  ? 35  THR B O   1 
ATOM   2438 C  CB  . THR B 1 36  ? -32.36865 -13.56946 9.98614   1.000 52.42680  ? 35  THR B CB  1 
ATOM   2439 O  OG1 . THR B 1 36  ? -31.77638 -14.65020 9.26140   1.000 59.39288  ? 35  THR B OG1 1 
ATOM   2440 C  CG2 . THR B 1 36  ? -33.88692 -13.68877 9.90231   1.000 55.77675  ? 35  THR B CG2 1 
ATOM   2441 N  N   . LYS B 1 37  ? -31.39245 -10.64139 11.18428  1.000 52.02500  ? 36  LYS B N   1 
ATOM   2442 C  CA  . LYS B 1 37  ? -31.70271 -9.47493  12.00223  1.000 65.17235  ? 36  LYS B CA  1 
ATOM   2443 C  C   . LYS B 1 37  ? -31.75072 -8.20883  11.15617  1.000 57.92521  ? 36  LYS B C   1 
ATOM   2444 O  O   . LYS B 1 37  ? -32.64947 -7.37742  11.33046  1.000 57.91111  ? 36  LYS B O   1 
ATOM   2445 C  CB  . LYS B 1 37  ? -30.69127 -9.32847  13.13577  1.000 66.79612  ? 36  LYS B CB  1 
ATOM   2446 C  CG  . LYS B 1 37  ? -31.25772 -8.58553  14.33755  1.000 68.85513  ? 36  LYS B CG  1 
ATOM   2447 C  CD  . LYS B 1 37  ? -30.30243 -8.59976  15.50778  1.000 65.86413  ? 36  LYS B CD  1 
ATOM   2448 C  CE  . LYS B 1 37  ? -29.35335 -7.42836  15.44139  1.000 68.43941  ? 36  LYS B CE  1 
ATOM   2449 N  NZ  . LYS B 1 37  ? -28.26029 -7.57783  16.42987  1.000 61.67844  ? 36  LYS B NZ  1 
ATOM   2450 N  N   . ARG B 1 38  ? -30.79831 -8.04439  10.23058  1.000 57.76456  ? 37  ARG B N   1 
ATOM   2451 C  CA  . ARG B 1 38  ? -30.89074 -6.93708  9.28413   1.000 59.28362  ? 37  ARG B CA  1 
ATOM   2452 C  C   . ARG B 1 38  ? -32.13667 -7.06665  8.41711   1.000 62.22977  ? 37  ARG B C   1 
ATOM   2453 O  O   . ARG B 1 38  ? -32.76243 -6.06290  8.06307   1.000 70.32218  ? 37  ARG B O   1 
ATOM   2454 C  CB  . ARG B 1 38  ? -29.63889 -6.86151  8.41120   1.000 58.39509  ? 37  ARG B CB  1 
ATOM   2455 C  CG  . ARG B 1 38  ? -29.77347 -5.88434  7.24214   1.000 55.13612  ? 37  ARG B CG  1 
ATOM   2456 C  CD  . ARG B 1 38  ? -28.47325 -5.74849  6.47362   1.000 59.83454  ? 37  ARG B CD  1 
ATOM   2457 N  NE  . ARG B 1 38  ? -27.87226 -7.04592  6.18835   1.000 55.65770  ? 37  ARG B NE  1 
ATOM   2458 C  CZ  . ARG B 1 38  ? -28.02155 -7.71165  5.04971   1.000 69.04088  ? 37  ARG B CZ  1 
ATOM   2459 N  NH1 . ARG B 1 38  ? -28.72479 -7.21875  4.04191   1.000 66.33176  ? 37  ARG B NH1 1 
ATOM   2460 N  NH2 . ARG B 1 38  ? -27.44595 -8.90093  4.91414   1.000 65.05670  ? 37  ARG B NH2 1 
ATOM   2461 N  N   . GLY B 1 39  ? -32.50848 -8.29541  8.05530   1.000 50.91232  ? 38  GLY B N   1 
ATOM   2462 C  CA  . GLY B 1 39  ? -33.73055 -8.48343  7.28785   1.000 57.46345  ? 38  GLY B CA  1 
ATOM   2463 C  C   . GLY B 1 39  ? -34.95701 -8.00122  8.03652   1.000 59.55902  ? 38  GLY B C   1 
ATOM   2464 O  O   . GLY B 1 39  ? -35.81660 -7.31771  7.47676   1.000 69.62892  ? 38  GLY B O   1 
ATOM   2465 N  N   . PHE B 1 40  ? -35.04708 -8.34812  9.32083   1.000 59.27701  ? 39  PHE B N   1 
ATOM   2466 C  CA  . PHE B 1 40  ? -36.15223 -7.86877  10.14521  1.000 66.99667  ? 39  PHE B CA  1 
ATOM   2467 C  C   . PHE B 1 40  ? -36.10203 -6.35542  10.31750  1.000 66.41457  ? 39  PHE B C   1 
ATOM   2468 O  O   . PHE B 1 40  ? -37.14258 -5.68746  10.31419  1.000 64.78990  ? 39  PHE B O   1 
ATOM   2469 C  CB  . PHE B 1 40  ? -36.13934 -8.56225  11.50947  1.000 63.05163  ? 39  PHE B CB  1 
ATOM   2470 C  CG  . PHE B 1 40  ? -36.89525 -9.86482  11.53728  1.000 63.55112  ? 39  PHE B CG  1 
ATOM   2471 C  CD1 . PHE B 1 40  ? -38.26608 -9.89101  11.32389  1.000 65.97034  ? 39  PHE B CD1 1 
ATOM   2472 C  CD2 . PHE B 1 40  ? -36.24023 -11.05913 11.79751  1.000 66.98369  ? 39  PHE B CD2 1 
ATOM   2473 C  CE1 . PHE B 1 40  ? -38.96545 -11.08568 11.35213  1.000 59.65196  ? 39  PHE B CE1 1 
ATOM   2474 C  CE2 . PHE B 1 40  ? -36.93756 -12.25745 11.82967  1.000 65.98924  ? 39  PHE B CE2 1 
ATOM   2475 C  CZ  . PHE B 1 40  ? -38.30002 -12.26810 11.60722  1.000 59.34580  ? 39  PHE B CZ  1 
ATOM   2476 N  N   . GLU B 1 41  ? -34.90254 -5.79700  10.47482  1.000 63.61837  ? 40  GLU B N   1 
ATOM   2477 C  CA  . GLU B 1 41  ? -34.75519 -4.37478  10.74901  1.000 63.57684  ? 40  GLU B CA  1 
ATOM   2478 C  C   . GLU B 1 41  ? -34.91389 -3.49956  9.51416   1.000 71.65815  ? 40  GLU B C   1 
ATOM   2479 O  O   . GLU B 1 41  ? -35.13440 -2.29255  9.66478   1.000 69.80544  ? 40  GLU B O   1 
ATOM   2480 C  CB  . GLU B 1 41  ? -33.38942 -4.10467  11.38646  1.000 58.40686  ? 40  GLU B CB  1 
ATOM   2481 C  CG  . GLU B 1 41  ? -33.29252 -4.46809  12.85631  1.000 67.85642  ? 40  GLU B CG  1 
ATOM   2482 C  CD  . GLU B 1 41  ? -31.85691 -4.63336  13.31255  1.000 70.32124  ? 40  GLU B CD  1 
ATOM   2483 O  OE1 . GLU B 1 41  ? -30.94918 -4.57684  12.45490  1.000 72.35156  ? 40  GLU B OE1 1 
ATOM   2484 O  OE2 . GLU B 1 41  ? -31.63191 -4.82661  14.52538  1.000 78.00339  ? 40  GLU B OE2 1 
ATOM   2485 N  N   . LYS B 1 42  ? -34.80676 -4.06527  8.31006   1.000 65.15802  ? 41  LYS B N   1 
ATOM   2486 C  CA  . LYS B 1 42  ? -34.82204 -3.25536  7.09459   1.000 65.62106  ? 41  LYS B CA  1 
ATOM   2487 C  C   . LYS B 1 42  ? -35.70003 -3.78682  5.97196   1.000 69.13024  ? 41  LYS B C   1 
ATOM   2488 O  O   . LYS B 1 42  ? -35.97281 -3.02791  5.03588   1.000 72.64657  ? 41  LYS B O   1 
ATOM   2489 C  CB  . LYS B 1 42  ? -33.39693 -3.07822  6.55578   1.000 68.94980  ? 41  LYS B CB  1 
ATOM   2490 C  CG  . LYS B 1 42  ? -32.53968 -2.13744  7.38119   1.000 71.56831  ? 41  LYS B CG  1 
ATOM   2491 C  CD  . LYS B 1 42  ? -33.08195 -0.72526  7.30495   1.000 71.52936  ? 41  LYS B CD  1 
ATOM   2492 C  CE  . LYS B 1 42  ? -32.48695 0.14384   8.38792   1.000 72.20731  ? 41  LYS B CE  1 
ATOM   2493 N  NZ  . LYS B 1 42  ? -33.09325 1.49969   8.34220   1.000 74.87956  ? 41  LYS B NZ  1 
ATOM   2494 N  N   . ALA B 1 43  ? -36.16300 -5.03731  6.00772   1.000 67.32439  ? 42  ALA B N   1 
ATOM   2495 C  CA  . ALA B 1 43  ? -37.00217 -5.56269  4.94056   1.000 66.17698  ? 42  ALA B CA  1 
ATOM   2496 C  C   . ALA B 1 43  ? -38.38299 -5.98868  5.40891   1.000 67.49103  ? 42  ALA B C   1 
ATOM   2497 O  O   . ALA B 1 43  ? -39.30132 -6.06463  4.58412   1.000 67.94313  ? 42  ALA B O   1 
ATOM   2498 C  CB  . ALA B 1 43  ? -36.32220 -6.75827  4.25410   1.000 61.95304  ? 42  ALA B CB  1 
ATOM   2499 N  N   . ARG B 1 44  ? -38.55328 -6.27847  6.69801   1.000 66.22377  ? 43  ARG B N   1 
ATOM   2500 C  CA  . ARG B 1 44  ? -39.86257 -6.51489  7.29161   1.000 71.01836  ? 43  ARG B CA  1 
ATOM   2501 C  C   . ARG B 1 44  ? -40.20371 -5.43195  8.30406   1.000 75.60899  ? 43  ARG B C   1 
ATOM   2502 O  O   . ARG B 1 44  ? -41.10386 -5.61542  9.12681   1.000 79.59013  ? 43  ARG B O   1 
ATOM   2503 C  CB  . ARG B 1 44  ? -39.91885 -7.89686  7.94268   1.000 69.76836  ? 43  ARG B CB  1 
ATOM   2504 C  CG  . ARG B 1 44  ? -39.57952 -9.02898  6.98764   1.000 77.29109  ? 43  ARG B CG  1 
ATOM   2505 C  CD  . ARG B 1 44  ? -39.65648 -10.37874 7.68022   1.000 67.26296  ? 43  ARG B CD  1 
ATOM   2506 N  NE  . ARG B 1 44  ? -40.99971 -10.68625 8.15533   1.000 65.33746  ? 43  ARG B NE  1 
ATOM   2507 C  CZ  . ARG B 1 44  ? -41.34730 -11.84151 8.70624   1.000 58.84095  ? 43  ARG B CZ  1 
ATOM   2508 N  NH1 . ARG B 1 44  ? -40.47515 -12.82530 8.85801   1.000 56.87794  ? 43  ARG B NH1 1 
ATOM   2509 N  NH2 . ARG B 1 44  ? -42.60054 -12.01494 9.11552   1.000 59.42163  ? 43  ARG B NH2 1 
ATOM   2510 N  N   . ASN B 1 45  ? -39.49877 -4.29943  8.24120   1.000 72.17059  ? 44  ASN B N   1 
ATOM   2511 C  CA  . ASN B 1 45  ? -39.65922 -3.24188  9.23431   1.000 76.42513  ? 44  ASN B CA  1 
ATOM   2512 C  C   . ASN B 1 45  ? -41.09168 -2.72579  9.29440   1.000 77.97217  ? 44  ASN B C   1 
ATOM   2513 O  O   . ASN B 1 45  ? -41.63258 -2.49740  10.38205  1.000 76.02317  ? 44  ASN B O   1 
ATOM   2514 C  CB  . ASN B 1 45  ? -38.69364 -2.10087  8.92187   1.000 77.21872  ? 44  ASN B CB  1 
ATOM   2515 C  CG  . ASN B 1 45  ? -38.73196 -1.69546  7.46015   1.000 81.18711  ? 44  ASN B CG  1 
ATOM   2516 O  OD1 . ASN B 1 45  ? -39.73527 -1.89102  6.77866   1.000 80.36462  ? 44  ASN B OD1 1 
ATOM   2517 N  ND2 . ASN B 1 45  ? -37.63222 -1.13685  6.96883   1.000 83.21191  ? 44  ASN B ND2 1 
ATOM   2518 N  N   . LYS B 1 46  ? -41.72640 -2.54195  8.14022   1.000 84.02301  ? 45  LYS B N   1 
ATOM   2519 C  CA  . LYS B 1 46  ? -43.07084 -1.98688  8.09528   1.000 82.06662  ? 45  LYS B CA  1 
ATOM   2520 C  C   . LYS B 1 46  ? -44.15224 -3.02759  8.36455   1.000 78.43640  ? 45  LYS B C   1 
ATOM   2521 O  O   . LYS B 1 46  ? -45.31420 -2.80734  8.00565   1.000 84.34114  ? 45  LYS B O   1 
ATOM   2522 C  CB  . LYS B 1 46  ? -43.30738 -1.30190  6.74769   1.000 81.26903  ? 45  LYS B CB  1 
ATOM   2523 C  CG  . LYS B 1 46  ? -42.33777 -0.16538  6.48482   1.000 84.18182  ? 45  LYS B CG  1 
ATOM   2524 C  CD  . LYS B 1 46  ? -42.35062 0.81456   7.64917   1.000 85.76952  ? 45  LYS B CD  1 
ATOM   2525 C  CE  . LYS B 1 46  ? -41.11937 1.69983   7.65024   1.000 87.32860  ? 45  LYS B CE  1 
ATOM   2526 N  NZ  . LYS B 1 46  ? -41.10711 2.63015   6.49256   1.000 80.14436  ? 45  LYS B NZ  1 
ATOM   2527 N  N   . GLU B 1 47  ? -43.79715 -4.16189  8.97691   1.000 76.88243  ? 46  GLU B N   1 
ATOM   2528 C  CA  . GLU B 1 47  ? -44.82790 -5.09009  9.40739   1.000 78.95190  ? 46  GLU B CA  1 
ATOM   2529 C  C   . GLU B 1 47  ? -45.23359 -4.78460  10.84832  1.000 80.49283  ? 46  GLU B C   1 
ATOM   2530 O  O   . GLU B 1 47  ? -44.41806 -4.29409  11.63606  1.000 77.79979  ? 46  GLU B O   1 
ATOM   2531 C  CB  . GLU B 1 47  ? -44.32771 -6.52913  9.29261   1.000 77.53938  ? 46  GLU B CB  1 
ATOM   2532 C  CG  . GLU B 1 47  ? -43.83010 -6.89905  7.90037   1.000 80.10005  ? 46  GLU B CG  1 
ATOM   2533 C  CD  . GLU B 1 47  ? -43.52840 -8.37979  7.75066   1.000 79.72962  ? 46  GLU B CD  1 
ATOM   2534 O  OE1 . GLU B 1 47  ? -43.79380 -9.14481  8.69858   1.000 73.71902  ? 46  GLU B OE1 1 
ATOM   2535 O  OE2 . GLU B 1 47  ? -43.02573 -8.78229  6.67911   1.000 83.09225  ? 46  GLU B OE2 1 
ATOM   2536 N  N   . PRO B 1 48  ? -46.49564 -5.04449  11.21271  1.000 80.65214  ? 47  PRO B N   1 
ATOM   2537 C  CA  . PRO B 1 48  ? -46.97310 -4.63374  12.55056  1.000 79.99224  ? 47  PRO B CA  1 
ATOM   2538 C  C   . PRO B 1 48  ? -46.13969 -5.14945  13.71357  1.000 86.14421  ? 47  PRO B C   1 
ATOM   2539 O  O   . PRO B 1 48  ? -45.70141 -4.35473  14.55708  1.000 89.15001  ? 47  PRO B O   1 
ATOM   2540 C  CB  . PRO B 1 48  ? -48.39953 -5.19614  12.59207  1.000 77.91246  ? 47  PRO B CB  1 
ATOM   2541 C  CG  . PRO B 1 48  ? -48.80711 -5.28577  11.15806  1.000 74.20661  ? 47  PRO B CG  1 
ATOM   2542 C  CD  . PRO B 1 48  ? -47.56823 -5.63987  10.39783  1.000 76.86530  ? 47  PRO B CD  1 
ATOM   2543 N  N   . GLU B 1 49  ? -45.92049 -6.46416  13.79461  1.000 86.56091  ? 48  GLU B N   1 
ATOM   2544 C  CA  . GLU B 1 49  ? -45.19352 -7.01440  14.93372  1.000 81.92755  ? 48  GLU B CA  1 
ATOM   2545 C  C   . GLU B 1 49  ? -43.74093 -6.56299  14.94514  1.000 80.19105  ? 48  GLU B C   1 
ATOM   2546 O  O   . GLU B 1 49  ? -43.17753 -6.31923  16.01838  1.000 83.49970  ? 48  GLU B O   1 
ATOM   2547 C  CB  . GLU B 1 49  ? -45.26471 -8.53875  14.91848  1.000 84.64880  ? 48  GLU B CB  1 
ATOM   2548 C  CG  . GLU B 1 49  ? -46.65236 -9.08879  14.68718  1.000 95.07414  ? 48  GLU B CG  1 
ATOM   2549 C  CD  . GLU B 1 49  ? -46.81576 -9.66586  13.30169  1.000 104.68845 ? 48  GLU B CD  1 
ATOM   2550 O  OE1 . GLU B 1 49  ? -46.64159 -8.92010  12.31514  1.000 96.44501  ? 48  GLU B OE1 1 
ATOM   2551 O  OE2 . GLU B 1 49  ? -47.10769 -10.87398 13.19779  1.000 104.20048 ? 48  GLU B OE2 1 
ATOM   2552 N  N   . VAL B 1 50  ? -43.11943 -6.45911  13.76985  1.000 75.40760  ? 49  VAL B N   1 
ATOM   2553 C  CA  . VAL B 1 50  ? -41.74465 -5.97908  13.69600  1.000 75.67059  ? 49  VAL B CA  1 
ATOM   2554 C  C   . VAL B 1 50  ? -41.67068 -4.54447  14.19718  1.000 82.46755  ? 49  VAL B C   1 
ATOM   2555 O  O   . VAL B 1 50  ? -40.78324 -4.18587  14.98043  1.000 81.10399  ? 49  VAL B O   1 
ATOM   2556 C  CB  . VAL B 1 50  ? -41.20980 -6.10980  12.25886  1.000 74.04470  ? 49  VAL B CB  1 
ATOM   2557 C  CG1 . VAL B 1 50  ? -39.71596 -5.84333  12.22527  1.000 71.97003  ? 49  VAL B CG1 1 
ATOM   2558 C  CG2 . VAL B 1 50  ? -41.52893 -7.48712  11.69979  1.000 74.27777  ? 49  VAL B CG2 1 
ATOM   2559 N  N   . GLN B 1 51  ? -42.62072 -3.70720  13.76543  1.000 83.83789  ? 50  GLN B N   1 
ATOM   2560 C  CA  . GLN B 1 51  ? -42.65879 -2.32124  14.22275  1.000 82.46432  ? 50  GLN B CA  1 
ATOM   2561 C  C   . GLN B 1 51  ? -42.84736 -2.24634  15.73335  1.000 84.15713  ? 50  GLN B C   1 
ATOM   2562 O  O   . GLN B 1 51  ? -42.24201 -1.39908  16.39947  1.000 83.64379  ? 50  GLN B O   1 
ATOM   2563 C  CB  . GLN B 1 51  ? -43.77524 -1.55986  13.50372  1.000 80.88305  ? 50  GLN B CB  1 
ATOM   2564 C  CG  . GLN B 1 51  ? -43.78903 -0.04764  13.73842  1.000 89.50147  ? 50  GLN B CG  1 
ATOM   2565 C  CD  . GLN B 1 51  ? -44.91209 0.65683   12.99536  1.000 95.93867  ? 50  GLN B CD  1 
ATOM   2566 O  OE1 . GLN B 1 51  ? -44.68703 1.30546   11.97010  1.000 104.66632 ? 50  GLN B OE1 1 
ATOM   2567 N  NE2 . GLN B 1 51  ? -46.12875 0.53782   13.51493  1.000 89.95003  ? 50  GLN B NE2 1 
ATOM   2568 N  N   . ARG B 1 52  ? -43.69141 -3.11876  16.29289  1.000 84.79626  ? 51  ARG B N   1 
ATOM   2569 C  CA  . ARG B 1 52  ? -43.89576 -3.11854  17.73979  1.000 84.40766  ? 51  ARG B CA  1 
ATOM   2570 C  C   . ARG B 1 52  ? -42.62396 -3.51617  18.48031  1.000 86.75209  ? 51  ARG B C   1 
ATOM   2571 O  O   . ARG B 1 52  ? -42.15306 -2.78861  19.36288  1.000 98.00717  ? 51  ARG B O   1 
ATOM   2572 C  CB  . ARG B 1 52  ? -45.03857 -4.06289  18.10452  1.000 83.32749  ? 51  ARG B CB  1 
ATOM   2573 C  CG  . ARG B 1 52  ? -45.07007 -4.48042  19.56735  1.000 86.65472  ? 51  ARG B CG  1 
ATOM   2574 C  CD  . ARG B 1 52  ? -46.35844 -5.22239  19.88026  1.000 98.53125  ? 51  ARG B CD  1 
ATOM   2575 N  NE  . ARG B 1 52  ? -46.34515 -5.85968  21.19151  1.000 111.13187 ? 51  ARG B NE  1 
ATOM   2576 C  CZ  . ARG B 1 52  ? -46.13075 -7.15278  21.39427  1.000 92.71907  ? 51  ARG B CZ  1 
ATOM   2577 N  NH1 . ARG B 1 52  ? -45.89381 -7.98027  20.38988  1.000 90.03766  ? 51  ARG B NH1 1 
ATOM   2578 N  NH2 . ARG B 1 52  ? -46.16428 -7.62957  22.63549  1.000 90.86278  ? 51  ARG B NH2 1 
ATOM   2579 N  N   . LEU B 1 53  ? -42.03654 -4.65974  18.11537  1.000 82.07575  ? 52  LEU B N   1 
ATOM   2580 C  CA  . LEU B 1 53  ? -40.82109 -5.11216  18.78303  1.000 80.20234  ? 52  LEU B CA  1 
ATOM   2581 C  C   . LEU B 1 53  ? -39.66187 -4.15147  18.55817  1.000 80.49778  ? 52  LEU B C   1 
ATOM   2582 O  O   . LEU B 1 53  ? -38.69173 -4.18064  19.32245  1.000 78.16970  ? 52  LEU B O   1 
ATOM   2583 C  CB  . LEU B 1 53  ? -40.43906 -6.52052  18.30989  1.000 68.33064  ? 52  LEU B CB  1 
ATOM   2584 C  CG  . LEU B 1 53  ? -41.40772 -7.67232  18.60175  1.000 70.24337  ? 52  LEU B CG  1 
ATOM   2585 C  CD1 . LEU B 1 53  ? -40.78025 -9.02166  18.25742  1.000 74.61088  ? 52  LEU B CD1 1 
ATOM   2586 C  CD2 . LEU B 1 53  ? -41.86485 -7.64585  20.05039  1.000 72.41122  ? 52  LEU B CD2 1 
ATOM   2587 N  N   . LEU B 1 54  ? -39.74358 -3.30056  17.53195  1.000 84.34301  ? 53  LEU B N   1 
ATOM   2588 C  CA  . LEU B 1 54  ? -38.73491 -2.28712  17.27235  1.000 83.12420  ? 53  LEU B CA  1 
ATOM   2589 C  C   . LEU B 1 54  ? -39.08029 -0.93364  17.87974  1.000 87.88223  ? 53  LEU B C   1 
ATOM   2590 O  O   . LEU B 1 54  ? -38.23360 -0.03443  17.86215  1.000 92.57686  ? 53  LEU B O   1 
ATOM   2591 C  CB  . LEU B 1 54  ? -38.53589 -2.13383  15.75985  1.000 84.95092  ? 53  LEU B CB  1 
ATOM   2592 C  CG  . LEU B 1 54  ? -37.11189 -1.94457  15.23628  1.000 81.28423  ? 53  LEU B CG  1 
ATOM   2593 C  CD1 . LEU B 1 54  ? -36.15580 -2.86149  15.97634  1.000 79.60643  ? 53  LEU B CD1 1 
ATOM   2594 C  CD2 . LEU B 1 54  ? -37.08512 -2.23132  13.74598  1.000 72.40381  ? 53  LEU B CD2 1 
ATOM   2595 N  N   . SER B 1 55  ? -40.29752 -0.76054  18.40769  1.000 91.31710  ? 54  SER B N   1 
ATOM   2596 C  CA  . SER B 1 55  ? -40.65548 0.51016   19.03142  1.000 98.72205  ? 54  SER B CA  1 
ATOM   2597 C  C   . SER B 1 55  ? -40.07463 0.61886   20.43543  1.000 102.77367 ? 54  SER B C   1 
ATOM   2598 O  O   . SER B 1 55  ? -39.59688 1.68832   20.83047  1.000 99.11349  ? 54  SER B O   1 
ATOM   2599 C  CB  . SER B 1 55  ? -42.17577 0.68025   19.07298  1.000 95.70893  ? 54  SER B CB  1 
ATOM   2600 O  OG  . SER B 1 55  ? -42.75357 -0.09998  20.10441  1.000 97.39314  ? 54  SER B OG  1 
ATOM   2601 N  N   . GLU B 1 56  ? -40.11715 -0.46858  21.20291  1.000 97.87244  ? 55  GLU B N   1 
ATOM   2602 C  CA  . GLU B 1 56  ? -39.50186 -0.47756  22.52072  1.000 99.98356  ? 55  GLU B CA  1 
ATOM   2603 C  C   . GLU B 1 56  ? -37.98379 -0.52954  22.39073  1.000 98.35801  ? 55  GLU B C   1 
ATOM   2604 O  O   . GLU B 1 56  ? -37.43689 -1.11554  21.45272  1.000 94.61441  ? 55  GLU B O   1 
ATOM   2605 C  CB  . GLU B 1 56  ? -40.00509 -1.66654  23.34039  1.000 98.85655  ? 55  GLU B CB  1 
ATOM   2606 C  CG  . GLU B 1 56  ? -41.51813 -1.74245  23.47493  1.000 107.06546 ? 55  GLU B CG  1 
ATOM   2607 C  CD  . GLU B 1 56  ? -41.98107 -3.02988  24.12600  1.000 119.31708 ? 55  GLU B CD  1 
ATOM   2608 O  OE1 . GLU B 1 56  ? -41.18318 -3.99052  24.17267  1.000 118.93167 ? 55  GLU B OE1 1 
ATOM   2609 O  OE2 . GLU B 1 56  ? -43.13835 -3.08313  24.59344  1.000 123.11044 ? 55  GLU B OE2 1 
ATOM   2610 N  N   . ASP B 1 57  ? -37.30392 0.10654   23.33818  1.000 97.96848  ? 56  ASP B N   1 
ATOM   2611 C  CA  . ASP B 1 57  ? -35.85131 0.12431   23.39732  1.000 92.91168  ? 56  ASP B CA  1 
ATOM   2612 C  C   . ASP B 1 57  ? -35.38551 -0.66643  24.61216  1.000 92.85001  ? 56  ASP B C   1 
ATOM   2613 O  O   . ASP B 1 57  ? -36.05984 -0.69213  25.64645  1.000 89.08219  ? 56  ASP B O   1 
ATOM   2614 C  CB  . ASP B 1 57  ? -35.31497 1.55808   23.48209  1.000 93.19852  ? 56  ASP B CB  1 
ATOM   2615 C  CG  . ASP B 1 57  ? -35.80601 2.43565   22.34863  1.000 101.76380 ? 56  ASP B CG  1 
ATOM   2616 O  OD1 . ASP B 1 57  ? -36.52941 1.92540   21.46751  1.000 103.88615 ? 56  ASP B OD1 1 
ATOM   2617 O  OD2 . ASP B 1 57  ? -35.46934 3.63771   22.33554  1.000 101.95793 ? 56  ASP B OD2 1 
ATOM   2618 N  N   . ASN B 1 58  ? -34.22960 -1.31714  24.48406  1.000 86.77788  ? 57  ASN B N   1 
ATOM   2619 C  CA  . ASN B 1 58  ? -33.69462 -2.04986  25.62010  1.000 79.50242  ? 57  ASN B CA  1 
ATOM   2620 C  C   . ASN B 1 58  ? -33.08699 -1.08328  26.63736  1.000 85.03736  ? 57  ASN B C   1 
ATOM   2621 O  O   . ASN B 1 58  ? -32.96847 0.12338   26.40210  1.000 85.07825  ? 57  ASN B O   1 
ATOM   2622 C  CB  . ASN B 1 58  ? -32.67538 -3.10504  25.16559  1.000 83.39175  ? 57  ASN B CB  1 
ATOM   2623 C  CG  . ASN B 1 58  ? -31.42023 -2.50741  24.52818  1.000 84.82377  ? 57  ASN B CG  1 
ATOM   2624 O  OD1 . ASN B 1 58  ? -31.11948 -1.32621  24.68520  1.000 92.33960  ? 57  ASN B OD1 1 
ATOM   2625 N  ND2 . ASN B 1 58  ? -30.66874 -3.34520  23.81965  1.000 82.93899  ? 57  ASN B ND2 1 
ATOM   2626 N  N   . GLN B 1 59  ? -32.72394 -1.63170  27.79433  1.000 80.16493  ? 58  GLN B N   1 
ATOM   2627 C  CA  . GLN B 1 59  ? -32.10213 -0.82009  28.83553  1.000 75.68764  ? 58  GLN B CA  1 
ATOM   2628 C  C   . GLN B 1 59  ? -30.77804 -0.19689  28.40582  1.000 77.66208  ? 58  GLN B C   1 
ATOM   2629 O  O   . GLN B 1 59  ? -30.55500 0.98160   28.73307  1.000 76.39470  ? 58  GLN B O   1 
ATOM   2630 C  CB  . GLN B 1 59  ? -31.94026 -1.67016  30.10111  1.000 74.86083  ? 58  GLN B CB  1 
ATOM   2631 C  CG  . GLN B 1 59  ? -30.75193 -1.32194  30.97638  1.000 73.79886  ? 58  GLN B CG  1 
ATOM   2632 C  CD  . GLN B 1 59  ? -30.56164 -2.31414  32.10758  1.000 81.07930  ? 58  GLN B CD  1 
ATOM   2633 O  OE1 . GLN B 1 59  ? -31.45286 -2.50679  32.93428  1.000 81.79178  ? 58  GLN B OE1 1 
ATOM   2634 N  NE2 . GLN B 1 59  ? -29.39862 -2.96079  32.14150  1.000 75.57197  ? 58  GLN B NE2 1 
ATOM   2635 N  N   . PRO B 1 60  ? -29.86961 -0.89514  27.70945  1.000 80.00920  ? 59  PRO B N   1 
ATOM   2636 C  CA  . PRO B 1 60  ? -28.66244 -0.20824  27.21361  1.000 80.44471  ? 59  PRO B CA  1 
ATOM   2637 C  C   . PRO B 1 60  ? -28.96399 1.03485   26.39632  1.000 76.67916  ? 59  PRO B C   1 
ATOM   2638 O  O   . PRO B 1 60  ? -28.29800 2.06902   26.56301  1.000 77.04705  ? 59  PRO B O   1 
ATOM   2639 C  CB  . PRO B 1 60  ? -27.97887 -1.28670  26.36327  1.000 67.62340  ? 59  PRO B CB  1 
ATOM   2640 C  CG  . PRO B 1 60  ? -28.39860 -2.56138  26.97371  1.000 71.82990  ? 59  PRO B CG  1 
ATOM   2641 C  CD  . PRO B 1 60  ? -29.78808 -2.35496  27.50832  1.000 76.32788  ? 59  PRO B CD  1 
ATOM   2642 N  N   . GLN B 1 61  ? -29.97662 0.96684   25.53141  1.000 75.86789  ? 60  GLN B N   1 
ATOM   2643 C  CA  . GLN B 1 61  ? -30.30983 2.11195   24.69311  1.000 80.33574  ? 60  GLN B CA  1 
ATOM   2644 C  C   . GLN B 1 61  ? -30.83586 3.27846   25.52159  1.000 78.33807  ? 60  GLN B C   1 
ATOM   2645 O  O   . GLN B 1 61  ? -30.42755 4.42744   25.30774  1.000 75.09244  ? 60  GLN B O   1 
ATOM   2646 C  CB  . GLN B 1 61  ? -31.32219 1.69640   23.62520  1.000 84.47005  ? 60  GLN B CB  1 
ATOM   2647 C  CG  . GLN B 1 61  ? -30.71089 0.85277   22.51275  1.000 84.66286  ? 60  GLN B CG  1 
ATOM   2648 C  CD  . GLN B 1 61  ? -31.70155 -0.11061  21.89293  1.000 86.63581  ? 60  GLN B CD  1 
ATOM   2649 O  OE1 . GLN B 1 61  ? -32.83599 -0.23049  22.35111  1.000 85.38004  ? 60  GLN B OE1 1 
ATOM   2650 N  NE2 . GLN B 1 61  ? -31.27414 -0.80882  20.84775  1.000 81.72976  ? 60  GLN B NE2 1 
ATOM   2651 N  N   . LYS B 1 62  ? -31.73226 3.00721   26.47735  1.000 79.16966  ? 61  LYS B N   1 
ATOM   2652 C  CA  . LYS B 1 62  ? -32.25620 4.08662   27.30917  1.000 83.61704  ? 61  LYS B CA  1 
ATOM   2653 C  C   . LYS B 1 62  ? -31.16651 4.68360   28.19233  1.000 76.26602  ? 61  LYS B C   1 
ATOM   2654 O  O   . LYS B 1 62  ? -31.16510 5.89501   28.44000  1.000 71.62144  ? 61  LYS B O   1 
ATOM   2655 C  CB  . LYS B 1 62  ? -33.41934 3.58197   28.16511  1.000 80.78186  ? 61  LYS B CB  1 
ATOM   2656 C  CG  . LYS B 1 62  ? -34.28587 4.67863   28.78317  1.000 81.71638  ? 61  LYS B CG  1 
ATOM   2657 C  CD  . LYS B 1 62  ? -35.43754 5.07896   27.86997  1.000 87.24177  ? 61  LYS B CD  1 
ATOM   2658 C  CE  . LYS B 1 62  ? -36.59291 5.66431   28.67302  1.000 88.64319  ? 61  LYS B CE  1 
ATOM   2659 N  NZ  . LYS B 1 62  ? -37.85102 5.72049   27.87822  1.000 93.61794  ? 61  LYS B NZ  1 
ATOM   2660 N  N   . ILE B 1 63  ? -30.22858 3.85904   28.66367  1.000 69.69001  ? 62  ILE B N   1 
ATOM   2661 C  CA  . ILE B 1 63  ? -29.09320 4.38256   29.41617  1.000 66.42892  ? 62  ILE B CA  1 
ATOM   2662 C  C   . ILE B 1 63  ? -28.30784 5.36329   28.55555  1.000 72.31505  ? 62  ILE B C   1 
ATOM   2663 O  O   . ILE B 1 63  ? -27.97520 6.47051   28.99442  1.000 62.86831  ? 62  ILE B O   1 
ATOM   2664 C  CB  . ILE B 1 63  ? -28.20286 3.23163   29.92222  1.000 69.22328  ? 62  ILE B CB  1 
ATOM   2665 C  CG1 . ILE B 1 63  ? -28.90756 2.44775   31.03208  1.000 68.47319  ? 62  ILE B CG1 1 
ATOM   2666 C  CG2 . ILE B 1 63  ? -26.86770 3.77001   30.42275  1.000 68.41580  ? 62  ILE B CG2 1 
ATOM   2667 C  CD1 . ILE B 1 63  ? -28.13779 1.22879   31.52309  1.000 72.98319  ? 62  ILE B CD1 1 
ATOM   2668 N  N   . GLY B 1 64  ? -28.01360 4.97454   27.30871  1.000 67.11197  ? 63  GLY B N   1 
ATOM   2669 C  CA  . GLY B 1 64  ? -27.29251 5.87340   26.41482  1.000 61.05229  ? 63  GLY B CA  1 
ATOM   2670 C  C   . GLY B 1 64  ? -28.03026 7.17343   26.15353  1.000 61.39949  ? 63  GLY B C   1 
ATOM   2671 O  O   . GLY B 1 64  ? -27.43653 8.25649   26.19454  1.000 64.36273  ? 63  GLY B O   1 
ATOM   2672 N  N   . LYS B 1 65  ? -29.33569 7.08484   25.88996  1.000 61.72366  ? 64  LYS B N   1 
ATOM   2673 C  CA  . LYS B 1 65  ? -30.12713 8.28430   25.61495  1.000 65.22965  ? 64  LYS B CA  1 
ATOM   2674 C  C   . LYS B 1 65  ? -30.12371 9.23019   26.81256  1.000 63.64846  ? 64  LYS B C   1 
ATOM   2675 O  O   . LYS B 1 65  ? -29.89811 10.44439  26.67075  1.000 63.26772  ? 64  LYS B O   1 
ATOM   2676 C  CB  . LYS B 1 65  ? -31.56725 7.90197   25.25013  1.000 70.46533  ? 64  LYS B CB  1 
ATOM   2677 C  CG  . LYS B 1 65  ? -31.68364 6.89358   24.12564  1.000 78.28955  ? 64  LYS B CG  1 
ATOM   2678 C  CD  . LYS B 1 65  ? -31.02409 7.39339   22.85610  1.000 76.27756  ? 64  LYS B CD  1 
ATOM   2679 C  CE  . LYS B 1 65  ? -30.48615 6.23890   22.03084  1.000 78.25066  ? 64  LYS B CE  1 
ATOM   2680 N  NZ  . LYS B 1 65  ? -29.33462 5.57887   22.69900  1.000 72.00848  ? 64  LYS B NZ  1 
ATOM   2681 N  N   . LEU B 1 66  ? -30.37142 8.68338   28.00804  1.000 66.16707  ? 65  LEU B N   1 
ATOM   2682 C  CA  . LEU B 1 66  ? -30.42333 9.50923   29.20755  1.000 66.96096  ? 65  LEU B CA  1 
ATOM   2683 C  C   . LEU B 1 66  ? -29.06473 10.12866  29.50915  1.000 61.26245  ? 65  LEU B C   1 
ATOM   2684 O  O   . LEU B 1 66  ? -28.98839 11.28372  29.94309  1.000 59.09915  ? 65  LEU B O   1 
ATOM   2685 C  CB  . LEU B 1 66  ? -30.92755 8.67697   30.38570  1.000 67.26256  ? 65  LEU B CB  1 
ATOM   2686 C  CG  . LEU B 1 66  ? -32.37785 8.19033   30.26911  1.000 64.37105  ? 65  LEU B CG  1 
ATOM   2687 C  CD1 . LEU B 1 66  ? -32.71205 7.18020   31.35068  1.000 68.77761  ? 65  LEU B CD1 1 
ATOM   2688 C  CD2 . LEU B 1 66  ? -33.34714 9.36005   30.31847  1.000 70.23097  ? 65  LEU B CD2 1 
ATOM   2689 N  N   . ALA B 1 67  ? -27.97732 9.38584   29.26769  1.000 57.25607  ? 66  ALA B N   1 
ATOM   2690 C  CA  . ALA B 1 67  ? -26.64538 9.95401   29.46065  1.000 60.22743  ? 66  ALA B CA  1 
ATOM   2691 C  C   . ALA B 1 67  ? -26.39325 11.12027  28.51041  1.000 61.93676  ? 66  ALA B C   1 
ATOM   2692 O  O   . ALA B 1 67  ? -25.83860 12.15572  28.91180  1.000 57.44622  ? 66  ALA B O   1 
ATOM   2693 C  CB  . ALA B 1 67  ? -25.58296 8.87340   29.27314  1.000 53.15938  ? 66  ALA B CB  1 
ATOM   2694 N  N   . GLN B 1 68  ? -26.78130 10.96655  27.24216  1.000 57.22387  ? 67  GLN B N   1 
ATOM   2695 C  CA  . GLN B 1 68  ? -26.58902 12.04802  26.28068  1.000 66.51139  ? 67  GLN B CA  1 
ATOM   2696 C  C   . GLN B 1 68  ? -27.34988 13.29883  26.70683  1.000 58.05768  ? 67  GLN B C   1 
ATOM   2697 O  O   . GLN B 1 68  ? -26.80147 14.41291  26.69559  1.000 62.44910  ? 67  GLN B O   1 
ATOM   2698 C  CB  . GLN B 1 68  ? -27.03169 11.59673  24.88667  1.000 60.76998  ? 67  GLN B CB  1 
ATOM   2699 C  CG  . GLN B 1 68  ? -26.62954 12.54529  23.77817  1.000 51.70139  ? 67  GLN B CG  1 
ATOM   2700 C  CD  . GLN B 1 68  ? -25.12811 12.59321  23.59523  1.000 52.85349  ? 67  GLN B CD  1 
ATOM   2701 O  OE1 . GLN B 1 68  ? -24.46742 11.55805  23.53665  1.000 62.35202  ? 67  GLN B OE1 1 
ATOM   2702 N  NE2 . GLN B 1 68  ? -24.57856 13.79549  23.51945  1.000 50.78974  ? 67  GLN B NE2 1 
ATOM   2703 N  N   . ARG B 1 69  ? -28.61828 13.13572  27.10573  1.000 57.01783  ? 68  ARG B N   1 
ATOM   2704 C  CA  . ARG B 1 69  ? -29.36597 14.32440  27.50855  1.000 59.04968  ? 68  ARG B CA  1 
ATOM   2705 C  C   . ARG B 1 69  ? -28.82688 14.90287  28.81408  1.000 62.63264  ? 68  ARG B C   1 
ATOM   2706 O  O   . ARG B 1 69  ? -28.90939 16.11576  29.03053  1.000 61.97853  ? 68  ARG B O   1 
ATOM   2707 C  CB  . ARG B 1 69  ? -30.86450 14.03877  27.62539  1.000 57.49765  ? 68  ARG B CB  1 
ATOM   2708 C  CG  . ARG B 1 69  ? -31.65859 15.33013  27.83693  1.000 62.91801  ? 68  ARG B CG  1 
ATOM   2709 C  CD  . ARG B 1 69  ? -33.15022 15.22206  27.59281  1.000 65.50755  ? 68  ARG B CD  1 
ATOM   2710 N  NE  . ARG B 1 69  ? -33.75722 16.54537  27.68856  1.000 76.87439  ? 68  ARG B NE  1 
ATOM   2711 C  CZ  . ARG B 1 69  ? -34.62219 16.91230  28.62566  1.000 80.51169  ? 68  ARG B CZ  1 
ATOM   2712 N  NH1 . ARG B 1 69  ? -35.08678 16.04989  29.51769  1.000 87.53093  ? 68  ARG B NH1 1 
ATOM   2713 N  NH2 . ARG B 1 69  ? -35.03680 18.17560  28.66671  1.000 75.39783  ? 68  ARG B NH2 1 
ATOM   2714 N  N   . GLY B 1 70  ? -28.26562 14.05905  29.68533  1.000 61.04415  ? 69  GLY B N   1 
ATOM   2715 C  CA  . GLY B 1 70  ? -27.64154 14.56130  30.90038  1.000 56.86589  ? 69  GLY B CA  1 
ATOM   2716 C  C   . GLY B 1 70  ? -26.45681 15.46485  30.61867  1.000 67.09272  ? 69  GLY B C   1 
ATOM   2717 O  O   . GLY B 1 70  ? -26.31855 16.53402  31.21883  1.000 65.61497  ? 69  GLY B O   1 
ATOM   2718 N  N   . VAL B 1 71  ? -25.57767 15.04156  29.70712  1.000 62.24800  ? 70  VAL B N   1 
ATOM   2719 C  CA  . VAL B 1 71  ? -24.47093 15.91158  29.30414  1.000 66.72708  ? 70  VAL B CA  1 
ATOM   2720 C  C   . VAL B 1 71  ? -25.00752 17.20573  28.69519  1.000 66.18842  ? 70  VAL B C   1 
ATOM   2721 O  O   . VAL B 1 71  ? -24.53400 18.31577  29.01270  1.000 72.01775  ? 70  VAL B O   1 
ATOM   2722 C  CB  . VAL B 1 71  ? -23.53564 15.16484  28.33507  1.000 57.73521  ? 70  VAL B CB  1 
ATOM   2723 C  CG1 . VAL B 1 71  ? -22.49881 16.11465  27.74667  1.000 60.53398  ? 70  VAL B CG1 1 
ATOM   2724 C  CG2 . VAL B 1 71  ? -22.86761 13.99953  29.05193  1.000 53.22352  ? 70  VAL B CG2 1 
ATOM   2725 N  N   . PHE B 1 72  ? -26.01839 17.08213  27.82430  1.000 64.47792  ? 71  PHE B N   1 
ATOM   2726 C  CA  . PHE B 1 72  ? -26.61352 18.25640  27.19010  1.000 67.14475  ? 71  PHE B CA  1 
ATOM   2727 C  C   . PHE B 1 72  ? -27.11708 19.24893  28.23130  1.000 68.48294  ? 71  PHE B C   1 
ATOM   2728 O  O   . PHE B 1 72  ? -26.88010 20.45799  28.12300  1.000 70.64144  ? 71  PHE B O   1 
ATOM   2729 C  CB  . PHE B 1 72  ? -27.75610 17.82364  26.27046  1.000 65.58718  ? 71  PHE B CB  1 
ATOM   2730 C  CG  . PHE B 1 72  ? -28.47810 18.96786  25.60942  1.000 65.70672  ? 71  PHE B CG  1 
ATOM   2731 C  CD1 . PHE B 1 72  ? -27.90090 19.64195  24.54687  1.000 69.01225  ? 71  PHE B CD1 1 
ATOM   2732 C  CD2 . PHE B 1 72  ? -29.74139 19.35503  26.03522  1.000 63.69407  ? 71  PHE B CD2 1 
ATOM   2733 C  CE1 . PHE B 1 72  ? -28.56402 20.69006  23.92629  1.000 67.18887  ? 71  PHE B CE1 1 
ATOM   2734 C  CE2 . PHE B 1 72  ? -30.40965 20.39920  25.41845  1.000 72.23511  ? 71  PHE B CE2 1 
ATOM   2735 C  CZ  . PHE B 1 72  ? -29.81970 21.06726  24.36313  1.000 71.55749  ? 71  PHE B CZ  1 
ATOM   2736 N  N   . GLU B 1 73  ? -27.81688 18.75113  29.25299  1.000 64.44387  ? 72  GLU B N   1 
ATOM   2737 C  CA  . GLU B 1 73  ? -28.35585 19.63232  30.28250  1.000 69.61523  ? 72  GLU B CA  1 
ATOM   2738 C  C   . GLU B 1 73  ? -27.24278 20.24529  31.12186  1.000 69.98049  ? 72  GLU B C   1 
ATOM   2739 O  O   . GLU B 1 73  ? -27.28037 21.44138  31.43635  1.000 70.35625  ? 72  GLU B O   1 
ATOM   2740 C  CB  . GLU B 1 73  ? -29.33914 18.87050  31.16856  1.000 73.09055  ? 72  GLU B CB  1 
ATOM   2741 C  CG  . GLU B 1 73  ? -30.53135 18.28459  30.43188  1.000 66.86254  ? 72  GLU B CG  1 
ATOM   2742 C  CD  . GLU B 1 73  ? -31.46984 19.33909  29.88003  1.000 69.71957  ? 72  GLU B CD  1 
ATOM   2743 O  OE1 . GLU B 1 73  ? -31.32601 20.53035  30.23263  1.000 68.66848  ? 72  GLU B OE1 1 
ATOM   2744 O  OE2 . GLU B 1 73  ? -32.36476 18.97244  29.09228  1.000 75.82285  ? 72  GLU B OE2 1 
ATOM   2745 N  N   . PHE B 1 74  ? -26.24664 19.43755  31.50644  1.000 68.44890  ? 73  PHE B N   1 
ATOM   2746 C  CA  . PHE B 1 74  ? -25.12782 19.96619  32.27861  1.000 60.19516  ? 73  PHE B CA  1 
ATOM   2747 C  C   . PHE B 1 74  ? -24.47136 21.13893  31.57260  1.000 65.23043  ? 73  PHE B C   1 
ATOM   2748 O  O   . PHE B 1 74  ? -23.94111 22.04268  32.22980  1.000 68.12962  ? 73  PHE B O   1 
ATOM   2749 C  CB  . PHE B 1 74  ? -24.09336 18.87169  32.53997  1.000 62.60121  ? 73  PHE B CB  1 
ATOM   2750 C  CG  . PHE B 1 74  ? -24.39813 18.01475  33.74162  1.000 72.51732  ? 73  PHE B CG  1 
ATOM   2751 C  CD1 . PHE B 1 74  ? -24.69008 18.58622  34.97315  1.000 66.33513  ? 73  PHE B CD1 1 
ATOM   2752 C  CD2 . PHE B 1 74  ? -24.38560 16.63322  33.64066  1.000 63.62313  ? 73  PHE B CD2 1 
ATOM   2753 C  CE1 . PHE B 1 74  ? -24.96442 17.78917  36.07773  1.000 63.23487  ? 73  PHE B CE1 1 
ATOM   2754 C  CE2 . PHE B 1 74  ? -24.66220 15.83748  34.73875  1.000 60.51585  ? 73  PHE B CE2 1 
ATOM   2755 C  CZ  . PHE B 1 74  ? -24.95205 16.41566  35.95694  1.000 66.26210  ? 73  PHE B CZ  1 
ATOM   2756 N  N   . HIS B 1 75  ? -24.49657 21.14994  30.24055  1.000 68.00756  ? 74  HIS B N   1 
ATOM   2757 C  CA  . HIS B 1 75  ? -23.92391 22.28603  29.52983  1.000 66.88535  ? 74  HIS B CA  1 
ATOM   2758 C  C   . HIS B 1 75  ? -24.95087 23.33574  29.11209  1.000 67.68804  ? 74  HIS B C   1 
ATOM   2759 O  O   . HIS B 1 75  ? -24.55550 24.42819  28.68500  1.000 60.13160  ? 74  HIS B O   1 
ATOM   2760 C  CB  . HIS B 1 75  ? -23.13432 21.79080  28.32061  1.000 55.39493  ? 74  HIS B CB  1 
ATOM   2761 C  CG  . HIS B 1 75  ? -21.85434 21.11916  28.70048  1.000 57.46663  ? 74  HIS B CG  1 
ATOM   2762 N  ND1 . HIS B 1 75  ? -20.62492 21.73185  28.58398  1.000 59.49818  ? 74  HIS B ND1 1 
ATOM   2763 C  CD2 . HIS B 1 75  ? -21.61841 19.90763  29.25366  1.000 58.73284  ? 74  HIS B CD2 1 
ATOM   2764 C  CE1 . HIS B 1 75  ? -19.68327 20.91602  29.02230  1.000 56.89835  ? 74  HIS B CE1 1 
ATOM   2765 N  NE2 . HIS B 1 75  ? -20.26024 19.80182  29.43366  1.000 62.53625  ? 74  HIS B NE2 1 
ATOM   2766 N  N   . GLN B 1 76  ? -26.24883 23.04588  29.23741  1.000 61.95458  ? 75  GLN B N   1 
ATOM   2767 C  CA  . GLN B 1 76  ? -27.25751 24.07238  28.99562  1.000 62.03721  ? 75  GLN B CA  1 
ATOM   2768 C  C   . GLN B 1 76  ? -27.14207 25.19084  30.01891  1.000 66.79760  ? 75  GLN B C   1 
ATOM   2769 O  O   . GLN B 1 76  ? -27.18241 26.37521  29.67226  1.000 72.84353  ? 75  GLN B O   1 
ATOM   2770 C  CB  . GLN B 1 76  ? -28.65699 23.46076  29.03523  1.000 64.27083  ? 75  GLN B CB  1 
ATOM   2771 C  CG  . GLN B 1 76  ? -29.05841 22.71867  27.77490  1.000 70.91187  ? 75  GLN B CG  1 
ATOM   2772 C  CD  . GLN B 1 76  ? -29.31772 23.63648  26.59174  1.000 68.71472  ? 75  GLN B CD  1 
ATOM   2773 O  OE1 . GLN B 1 76  ? -28.38786 24.10648  25.93404  1.000 68.83923  ? 75  GLN B OE1 1 
ATOM   2774 N  NE2 . GLN B 1 76  ? -30.59190 23.87802  26.30327  1.000 68.42342  ? 75  GLN B NE2 1 
ATOM   2775 N  N   . GLU B 1 77  ? -27.00072 24.83079  31.29111  1.000 74.56204  ? 76  GLU B N   1 
ATOM   2776 C  CA  . GLU B 1 77  ? -26.86763 25.79522  32.38070  1.000 71.80385  ? 76  GLU B CA  1 
ATOM   2777 C  C   . GLU B 1 77  ? -25.66507 25.36791  33.21653  1.000 61.81028  ? 76  GLU B C   1 
ATOM   2778 O  O   . GLU B 1 77  ? -25.77023 24.46130  34.04833  1.000 58.15923  ? 76  GLU B O   1 
ATOM   2779 C  CB  . GLU B 1 77  ? -28.14915 25.86494  33.21061  1.000 69.52165  ? 76  GLU B CB  1 
ATOM   2780 C  CG  . GLU B 1 77  ? -28.26566 27.09253  34.11488  1.000 92.36091  ? 76  GLU B CG  1 
ATOM   2781 C  CD  . GLU B 1 77  ? -28.32881 28.41363  33.34961  1.000 86.51914  ? 76  GLU B CD  1 
ATOM   2782 O  OE1 . GLU B 1 77  ? -28.57097 28.40500  32.12377  1.000 81.08319  ? 76  GLU B OE1 1 
ATOM   2783 O  OE2 . GLU B 1 77  ? -28.13632 29.47325  33.98347  1.000 95.01784  ? 76  GLU B OE2 1 
ATOM   2784 N  N   . LEU B 1 78  ? -24.52514 26.02983  32.99815  1.000 55.56563  ? 77  LEU B N   1 
ATOM   2785 C  CA  . LEU B 1 78  ? -23.28156 25.65047  33.66023  1.000 60.13946  ? 77  LEU B CA  1 
ATOM   2786 C  C   . LEU B 1 78  ? -23.38892 25.67010  35.18244  1.000 67.27467  ? 77  LEU B C   1 
ATOM   2787 O  O   . LEU B 1 78  ? -22.48702 25.15167  35.85610  1.000 60.35660  ? 77  LEU B O   1 
ATOM   2788 C  CB  . LEU B 1 78  ? -22.14638 26.56700  33.19435  1.000 54.76626  ? 77  LEU B CB  1 
ATOM   2789 C  CG  . LEU B 1 78  ? -21.79423 26.47885  31.70490  1.000 65.52179  ? 77  LEU B CG  1 
ATOM   2790 C  CD1 . LEU B 1 78  ? -20.62498 27.39406  31.36092  1.000 68.67535  ? 77  LEU B CD1 1 
ATOM   2791 C  CD2 . LEU B 1 78  ? -21.49247 25.03708  31.30358  1.000 68.84636  ? 77  LEU B CD2 1 
ATOM   2792 N  N   . VAL B 1 79  ? -24.47914 26.21576  35.73347  1.000 65.00306  ? 78  VAL B N   1 
ATOM   2793 C  CA  . VAL B 1 79  ? -24.70353 26.15068  37.17516  1.000 64.98304  ? 78  VAL B CA  1 
ATOM   2794 C  C   . VAL B 1 79  ? -24.63234 24.70388  37.64165  1.000 66.20940  ? 78  VAL B C   1 
ATOM   2795 O  O   . VAL B 1 79  ? -24.01090 24.38448  38.66021  1.000 61.03003  ? 78  VAL B O   1 
ATOM   2796 C  CB  . VAL B 1 79  ? -26.05641 26.78859  37.53877  1.000 71.25326  ? 78  VAL B CB  1 
ATOM   2797 C  CG1 . VAL B 1 79  ? -26.35968 26.58441  39.01904  1.000 68.83248  ? 78  VAL B CG1 1 
ATOM   2798 C  CG2 . VAL B 1 79  ? -26.07619 28.26633  37.16815  1.000 72.95400  ? 78  VAL B CG2 1 
ATOM   2799 N  N   . ARG B 1 80  ? -25.23294 23.79914  36.86809  1.000 65.47464  ? 79  ARG B N   1 
ATOM   2800 C  CA  . ARG B 1 80  ? -25.30142 22.38859  37.22989  1.000 65.68490  ? 79  ARG B CA  1 
ATOM   2801 C  C   . ARG B 1 80  ? -23.92528 21.73380  37.28402  1.000 57.32623  ? 79  ARG B C   1 
ATOM   2802 O  O   . ARG B 1 80  ? -23.81018 20.61069  37.79027  1.000 66.35789  ? 79  ARG B O   1 
ATOM   2803 C  CB  . ARG B 1 80  ? -26.20267 21.65577  36.22879  1.000 68.18953  ? 79  ARG B CB  1 
ATOM   2804 C  CG  . ARG B 1 80  ? -27.59891 22.24890  36.12392  1.000 73.17868  ? 79  ARG B CG  1 
ATOM   2805 C  CD  . ARG B 1 80  ? -28.20196 22.03452  34.74682  1.000 67.75833  ? 79  ARG B CD  1 
ATOM   2806 N  NE  . ARG B 1 80  ? -29.55525 22.57190  34.67817  1.000 75.77066  ? 79  ARG B NE  1 
ATOM   2807 C  CZ  . ARG B 1 80  ? -30.34678 22.48780  33.61676  1.000 79.52675  ? 79  ARG B CZ  1 
ATOM   2808 N  NH1 . ARG B 1 80  ? -29.94848 21.90151  32.49839  1.000 73.56439  ? 79  ARG B NH1 1 
ATOM   2809 N  NH2 . ARG B 1 80  ? -31.57221 23.00026  33.67971  1.000 79.03937  ? 79  ARG B NH2 1 
ATOM   2810 N  N   . LEU B 1 81  ? -22.88686 22.39604  36.76780  1.000 55.53128  ? 80  LEU B N   1 
ATOM   2811 C  CA  . LEU B 1 81  ? -21.51087 21.96458  36.97730  1.000 62.34028  ? 80  LEU B CA  1 
ATOM   2812 C  C   . LEU B 1 81  ? -20.80847 22.76632  38.06518  1.000 71.42125  ? 80  LEU B C   1 
ATOM   2813 O  O   . LEU B 1 81  ? -19.97801 22.21616  38.79607  1.000 70.48333  ? 80  LEU B O   1 
ATOM   2814 C  CB  . LEU B 1 81  ? -20.72029 22.06571  35.67120  1.000 56.36100  ? 80  LEU B CB  1 
ATOM   2815 C  CG  . LEU B 1 81  ? -21.19103 21.14752  34.54034  1.000 62.87645  ? 80  LEU B CG  1 
ATOM   2816 C  CD1 . LEU B 1 81  ? -20.36293 21.35611  33.27551  1.000 53.59919  ? 80  LEU B CD1 1 
ATOM   2817 C  CD2 . LEU B 1 81  ? -21.15392 19.68711  34.98249  1.000 61.41546  ? 80  LEU B CD2 1 
ATOM   2818 N  N   . SER B 1 82  ? -21.12827 24.05621  38.19181  1.000 66.46522  ? 81  SER B N   1 
ATOM   2819 C  CA  . SER B 1 82  ? -20.51545 24.90086  39.20773  1.000 69.90339  ? 81  SER B CA  1 
ATOM   2820 C  C   . SER B 1 82  ? -21.26676 24.85384  40.53033  1.000 69.27815  ? 81  SER B C   1 
ATOM   2821 O  O   . SER B 1 82  ? -20.65335 25.04740  41.58846  1.000 69.89567  ? 81  SER B O   1 
ATOM   2822 C  CB  . SER B 1 82  ? -20.44422 26.35022  38.72198  1.000 68.41681  ? 81  SER B CB  1 
ATOM   2823 O  OG  . SER B 1 82  ? -21.71643 26.96795  38.74752  1.000 60.34251  ? 81  SER B OG  1 
ATOM   2824 N  N   . GLY B 1 83  ? -22.57278 24.60169  40.49864  1.000 72.70459  ? 82  GLY B N   1 
ATOM   2825 C  CA  . GLY B 1 83  ? -23.34016 24.46835  41.71818  1.000 67.11938  ? 82  GLY B CA  1 
ATOM   2826 C  C   . GLY B 1 83  ? -22.99810 23.17823  42.43739  1.000 77.50984  ? 82  GLY B C   1 
ATOM   2827 O  O   . GLY B 1 83  ? -22.11594 22.41354  42.04346  1.000 88.29918  ? 82  GLY B O   1 
ATOM   2828 N  N   . SER B 1 84  ? -23.73426 22.92814  43.51774  1.000 78.21561  ? 83  SER B N   1 
ATOM   2829 C  CA  . SER B 1 84  ? -23.48926 21.75531  44.34730  1.000 78.35982  ? 83  SER B CA  1 
ATOM   2830 C  C   . SER B 1 84  ? -24.47492 20.62257  44.10016  1.000 70.54077  ? 83  SER B C   1 
ATOM   2831 O  O   . SER B 1 84  ? -24.10963 19.45094  44.25505  1.000 76.06125  ? 83  SER B O   1 
ATOM   2832 C  CB  . SER B 1 84  ? -23.53147 22.13667  45.83135  1.000 72.47155  ? 83  SER B CB  1 
ATOM   2833 O  OG  . SER B 1 84  ? -24.83992 22.51706  46.21547  1.000 84.14319  ? 83  SER B OG  1 
ATOM   2834 N  N   . HIS B 1 85  ? -25.70809 20.93917  43.70697  1.000 68.41027  ? 84  HIS B N   1 
ATOM   2835 C  CA  . HIS B 1 85  ? -26.75521 19.94054  43.54488  1.000 77.09372  ? 84  HIS B CA  1 
ATOM   2836 C  C   . HIS B 1 85  ? -27.09723 19.68325  42.07876  1.000 80.43401  ? 84  HIS B C   1 
ATOM   2837 O  O   . HIS B 1 85  ? -28.20663 19.23739  41.77729  1.000 77.50813  ? 84  HIS B O   1 
ATOM   2838 C  CB  . HIS B 1 85  ? -28.00037 20.36557  44.32395  1.000 74.64696  ? 84  HIS B CB  1 
ATOM   2839 C  CG  . HIS B 1 85  ? -27.71892 20.75215  45.74490  1.000 83.71211  ? 84  HIS B CG  1 
ATOM   2840 N  ND1 . HIS B 1 85  ? -27.24362 19.85863  46.68129  1.000 89.02631  ? 84  HIS B ND1 1 
ATOM   2841 C  CD2 . HIS B 1 85  ? -27.84177 21.93769  46.38800  1.000 76.47028  ? 84  HIS B CD2 1 
ATOM   2842 C  CE1 . HIS B 1 85  ? -27.08587 20.47578  47.83888  1.000 81.36247  ? 84  HIS B CE1 1 
ATOM   2843 N  NE2 . HIS B 1 85  ? -27.44179 21.73868  47.68797  1.000 78.82863  ? 84  HIS B NE2 1 
ATOM   2844 N  N   . GLY B 1 86  ? -26.15217 19.92849  41.16638  1.000 79.13714  ? 85  GLY B N   1 
ATOM   2845 C  CA  . GLY B 1 86  ? -26.45260 19.84615  39.74206  1.000 75.59996  ? 85  GLY B CA  1 
ATOM   2846 C  C   . GLY B 1 86  ? -26.86537 18.46033  39.27881  1.000 72.03444  ? 85  GLY B C   1 
ATOM   2847 O  O   . GLY B 1 86  ? -27.73683 18.32103  38.41819  1.000 77.60751  ? 85  GLY B O   1 
ATOM   2848 N  N   . VAL B 1 87  ? -26.22658 17.41921  39.81805  1.000 69.49738  ? 86  VAL B N   1 
ATOM   2849 C  CA  . VAL B 1 87  ? -26.58059 16.05207  39.44373  1.000 72.72892  ? 86  VAL B CA  1 
ATOM   2850 C  C   . VAL B 1 87  ? -28.03638 15.77229  39.78313  1.000 76.02719  ? 86  VAL B C   1 
ATOM   2851 O  O   . VAL B 1 87  ? -28.76264 15.15115  38.99955  1.000 81.40373  ? 86  VAL B O   1 
ATOM   2852 C  CB  . VAL B 1 87  ? -25.63358 15.04628  40.12596  1.000 67.55771  ? 86  VAL B CB  1 
ATOM   2853 C  CG1 . VAL B 1 87  ? -26.20980 13.63562  40.06369  1.000 61.30445  ? 86  VAL B CG1 1 
ATOM   2854 C  CG2 . VAL B 1 87  ? -24.26705 15.08965  39.46796  1.000 68.28325  ? 86  VAL B CG2 1 
ATOM   2855 N  N   . GLU B 1 88  ? -28.48613 16.22558  40.95471  1.000 70.73861  ? 87  GLU B N   1 
ATOM   2856 C  CA  . GLU B 1 88  ? -29.88122 16.03035  41.33495  1.000 73.75994  ? 87  GLU B CA  1 
ATOM   2857 C  C   . GLU B 1 88  ? -30.81724 16.78494  40.39819  1.000 75.99049  ? 87  GLU B C   1 
ATOM   2858 O  O   . GLU B 1 88  ? -31.86334 16.25617  39.99497  1.000 79.62833  ? 87  GLU B O   1 
ATOM   2859 C  CB  . GLU B 1 88  ? -30.09777 16.46895  42.78423  1.000 79.50071  ? 87  GLU B CB  1 
ATOM   2860 C  CG  . GLU B 1 88  ? -29.46432 15.55536  43.82931  1.000 84.98314  ? 87  GLU B CG  1 
ATOM   2861 C  CD  . GLU B 1 88  ? -27.95319 15.68690  43.90586  1.000 90.02595  ? 87  GLU B CD  1 
ATOM   2862 O  OE1 . GLU B 1 88  ? -27.44978 16.82638  43.82067  1.000 86.30937  ? 87  GLU B OE1 1 
ATOM   2863 O  OE2 . GLU B 1 88  ? -27.26884 14.65121  44.04692  1.000 83.40161  ? 87  GLU B OE2 1 
ATOM   2864 N  N   . GLN B 1 89  ? -30.44482 18.01348  40.02266  1.000 74.36897  ? 88  GLN B N   1 
ATOM   2865 C  CA  . GLN B 1 89  ? -31.26664 18.78719  39.09746  1.000 78.03674  ? 88  GLN B CA  1 
ATOM   2866 C  C   . GLN B 1 89  ? -31.39531 18.07570  37.75690  1.000 82.55903  ? 88  GLN B C   1 
ATOM   2867 O  O   . GLN B 1 89  ? -32.49428 17.96069  37.20238  1.000 85.26032  ? 88  GLN B O   1 
ATOM   2868 C  CB  . GLN B 1 89  ? -30.66548 20.17520  38.88594  1.000 79.87757  ? 88  GLN B CB  1 
ATOM   2869 C  CG  . GLN B 1 89  ? -30.22019 20.89738  40.13995  1.000 75.89311  ? 88  GLN B CG  1 
ATOM   2870 C  CD  . GLN B 1 89  ? -29.33059 22.08973  39.82777  1.000 72.58205  ? 88  GLN B CD  1 
ATOM   2871 O  OE1 . GLN B 1 89  ? -28.34221 22.33851  40.51616  1.000 65.93289  ? 88  GLN B OE1 1 
ATOM   2872 N  NE2 . GLN B 1 89  ? -29.67830 22.83093  38.78176  1.000 84.64466  ? 88  GLN B NE2 1 
ATOM   2873 N  N   . VAL B 1 90  ? -30.27152 17.59592  37.21749  1.000 81.40237  ? 89  VAL B N   1 
ATOM   2874 C  CA  . VAL B 1 90  ? -30.28685 16.93941  35.91385  1.000 80.03960  ? 89  VAL B CA  1 
ATOM   2875 C  C   . VAL B 1 90  ? -31.06569 15.63497  35.98865  1.000 82.75727  ? 89  VAL B C   1 
ATOM   2876 O  O   . VAL B 1 90  ? -31.82536 15.29515  35.07250  1.000 88.02157  ? 89  VAL B O   1 
ATOM   2877 C  CB  . VAL B 1 90  ? -28.84737 16.72391  35.40823  1.000 74.27818  ? 89  VAL B CB  1 
ATOM   2878 C  CG1 . VAL B 1 90  ? -28.80807 15.69598  34.28293  1.000 69.94302  ? 89  VAL B CG1 1 
ATOM   2879 C  CG2 . VAL B 1 90  ? -28.25441 18.04285  34.93106  1.000 70.20372  ? 89  VAL B CG2 1 
ATOM   2880 N  N   . ALA B 1 91  ? -30.91344 14.89648  37.09178  1.000 78.56885  ? 90  ALA B N   1 
ATOM   2881 C  CA  . ALA B 1 91  ? -31.67499 13.66866  37.26490  1.000 77.48596  ? 90  ALA B CA  1 
ATOM   2882 C  C   . ALA B 1 91  ? -33.16389 13.95431  37.36305  1.000 77.97737  ? 90  ALA B C   1 
ATOM   2883 O  O   . ALA B 1 91  ? -33.98361 13.11159  36.98139  1.000 79.20058  ? 90  ALA B O   1 
ATOM   2884 C  CB  . ALA B 1 91  ? -31.19053 12.92927  38.50834  1.000 73.49213  ? 90  ALA B CB  1 
ATOM   2885 N  N   . GLU B 1 92  ? -33.53030 15.12962  37.87506  1.000 80.77795  ? 91  GLU B N   1 
ATOM   2886 C  CA  . GLU B 1 92  ? -34.93394 15.51639  37.88436  1.000 83.50268  ? 91  GLU B CA  1 
ATOM   2887 C  C   . GLU B 1 92  ? -35.40913 15.93129  36.50006  1.000 85.54900  ? 91  GLU B C   1 
ATOM   2888 O  O   . GLU B 1 92  ? -36.58085 15.72120  36.16047  1.000 91.07372  ? 91  GLU B O   1 
ATOM   2889 C  CB  . GLU B 1 92  ? -35.16361 16.65317  38.87833  1.000 85.51313  ? 91  GLU B CB  1 
ATOM   2890 C  CG  . GLU B 1 92  ? -36.62788 17.02099  39.05688  1.000 89.94397  ? 91  GLU B CG  1 
ATOM   2891 C  CD  . GLU B 1 92  ? -36.81963 18.22849  39.94970  1.000 89.02558  ? 91  GLU B CD  1 
ATOM   2892 O  OE1 . GLU B 1 92  ? -36.38998 18.17643  41.12066  1.000 95.78700  ? 91  GLU B OE1 1 
ATOM   2893 O  OE2 . GLU B 1 92  ? -37.39134 19.23699  39.48230  1.000 83.74751  ? 91  GLU B OE2 1 
ATOM   2894 N  N   . ILE B 1 93  ? -34.52172 16.52868  35.70103  1.000 84.66922  ? 92  ILE B N   1 
ATOM   2895 C  CA  . ILE B 1 93  ? -34.86313 16.85234  34.32034  1.000 82.33359  ? 92  ILE B CA  1 
ATOM   2896 C  C   . ILE B 1 93  ? -34.98697 15.58027  33.49225  1.000 80.42754  ? 92  ILE B C   1 
ATOM   2897 O  O   . ILE B 1 93  ? -35.91470 15.43417  32.68738  1.000 78.25286  ? 92  ILE B O   1 
ATOM   2898 C  CB  . ILE B 1 93  ? -33.82298 17.81979  33.72628  1.000 83.32648  ? 92  ILE B CB  1 
ATOM   2899 C  CG1 . ILE B 1 93  ? -33.71421 19.08954  34.57890  1.000 76.30640  ? 92  ILE B CG1 1 
ATOM   2900 C  CG2 . ILE B 1 93  ? -34.16568 18.17254  32.28054  1.000 85.58059  ? 92  ILE B CG2 1 
ATOM   2901 C  CD1 . ILE B 1 93  ? -35.02968 19.80202  34.78592  1.000 81.37955  ? 92  ILE B CD1 1 
ATOM   2902 N  N   . LEU B 1 94  ? -34.06836 14.63229  33.68848  1.000 79.59491  ? 93  LEU B N   1 
ATOM   2903 C  CA  . LEU B 1 94  ? -34.12234 13.36048  32.97834  1.000 81.49946  ? 93  LEU B CA  1 
ATOM   2904 C  C   . LEU B 1 94  ? -35.25820 12.46790  33.45437  1.000 79.90379  ? 93  LEU B C   1 
ATOM   2905 O  O   . LEU B 1 94  ? -35.42066 11.36565  32.91488  1.000 87.55218  ? 93  LEU B O   1 
ATOM   2906 C  CB  . LEU B 1 94  ? -32.79377 12.61793  33.12663  1.000 75.27241  ? 93  LEU B CB  1 
ATOM   2907 C  CG  . LEU B 1 94  ? -31.52394 13.30915  32.62705  1.000 74.57903  ? 93  LEU B CG  1 
ATOM   2908 C  CD1 . LEU B 1 94  ? -30.33414 12.37417  32.75915  1.000 64.58393  ? 93  LEU B CD1 1 
ATOM   2909 C  CD2 . LEU B 1 94  ? -31.68439 13.79083  31.19258  1.000 69.10099  ? 93  LEU B CD2 1 
ATOM   2910 N  N   . GLN B 1 95  ? -36.04100 12.92266  34.43428  1.000 81.96934  ? 94  GLN B N   1 
ATOM   2911 C  CA  . GLN B 1 95  ? -37.13940 12.15254  35.00226  1.000 84.34089  ? 94  GLN B CA  1 
ATOM   2912 C  C   . GLN B 1 95  ? -36.69550 10.74101  35.35182  1.000 85.97303  ? 94  GLN B C   1 
ATOM   2913 O  O   . GLN B 1 95  ? -37.39287 9.77157   35.03954  1.000 89.80281  ? 94  GLN B O   1 
ATOM   2914 C  CB  . GLN B 1 95  ? -38.32097 12.11103  34.03628  1.000 83.63144  ? 94  GLN B CB  1 
ATOM   2915 C  CG  . GLN B 1 95  ? -38.93338 13.46236  33.76240  1.000 81.66088  ? 94  GLN B CG  1 
ATOM   2916 C  CD  . GLN B 1 95  ? -40.12066 13.36480  32.84210  1.000 95.47335  ? 94  GLN B CD  1 
ATOM   2917 O  OE1 . GLN B 1 95  ? -41.26129 13.55972  33.25839  1.000 95.36298  ? 94  GLN B OE1 1 
ATOM   2918 N  NE2 . GLN B 1 95  ? -39.86349 13.05126  31.58229  1.000 92.29987  ? 94  GLN B NE2 1 
ATOM   2919 N  N   . LEU B 1 96  ? -35.53325 10.61470  35.99523  1.000 80.68196  ? 95  LEU B N   1 
ATOM   2920 C  CA  . LEU B 1 96  ? -35.04008 9.29478   36.36764  1.000 83.64604  ? 95  LEU B CA  1 
ATOM   2921 C  C   . LEU B 1 96  ? -35.98171 8.58022   37.32717  1.000 88.77651  ? 95  LEU B C   1 
ATOM   2922 O  O   . LEU B 1 96  ? -35.91077 7.35254   37.44207  1.000 87.03647  ? 95  LEU B O   1 
ATOM   2923 C  CB  . LEU B 1 96  ? -33.64723 9.40131   36.98759  1.000 83.07703  ? 95  LEU B CB  1 
ATOM   2924 C  CG  . LEU B 1 96  ? -32.48601 9.80309   36.07774  1.000 78.50307  ? 95  LEU B CG  1 
ATOM   2925 C  CD1 . LEU B 1 96  ? -31.19061 9.74181   36.86714  1.000 77.13127  ? 95  LEU B CD1 1 
ATOM   2926 C  CD2 . LEU B 1 96  ? -32.42014 8.91142   34.84291  1.000 80.02086  ? 95  LEU B CD2 1 
ATOM   2927 N  N   . ASN B 1 97  ? -36.87301 9.31800   37.99848  1.000 93.58945  ? 96  ASN B N   1 
ATOM   2928 C  CA  . ASN B 1 97  ? -37.88797 8.69066   38.84088  1.000 93.85604  ? 96  ASN B CA  1 
ATOM   2929 C  C   . ASN B 1 97  ? -38.72958 7.69768   38.04920  1.000 92.43972  ? 96  ASN B C   1 
ATOM   2930 O  O   . ASN B 1 97  ? -39.15408 6.66913   38.58624  1.000 94.28700  ? 96  ASN B O   1 
ATOM   2931 C  CB  . ASN B 1 97  ? -38.78399 9.75886   39.46736  1.000 90.49777  ? 96  ASN B CB  1 
ATOM   2932 C  CG  . ASN B 1 97  ? -39.59627 10.51135  38.43515  1.000 102.88441 ? 96  ASN B CG  1 
ATOM   2933 O  OD1 . ASN B 1 97  ? -39.04615 11.23776  37.60743  1.000 96.21604  ? 96  ASN B OD1 1 
ATOM   2934 N  ND2 . ASN B 1 97  ? -40.91433 10.34618  38.48137  1.000 106.38450 ? 96  ASN B ND2 1 
ATOM   2935 N  N   . GLN B 1 98  ? -38.96776 7.97834   36.76857  1.000 93.31986  ? 97  GLN B N   1 
ATOM   2936 C  CA  . GLN B 1 98  ? -39.77894 7.12395   35.91079  1.000 96.47325  ? 97  GLN B CA  1 
ATOM   2937 C  C   . GLN B 1 98  ? -38.97041 6.02333   35.23982  1.000 94.95584  ? 97  GLN B C   1 
ATOM   2938 O  O   . GLN B 1 98  ? -39.48613 5.35588   34.33681  1.000 104.63051 ? 97  GLN B O   1 
ATOM   2939 C  CB  . GLN B 1 98  ? -40.48360 7.96001   34.84046  1.000 96.23036  ? 97  GLN B CB  1 
ATOM   2940 C  CG  . GLN B 1 98  ? -41.51292 8.92643   35.39330  1.000 103.51204 ? 97  GLN B CG  1 
ATOM   2941 C  CD  . GLN B 1 98  ? -41.62252 10.18185  34.56606  1.000 108.42295 ? 97  GLN B CD  1 
ATOM   2942 O  OE1 . GLN B 1 98  ? -41.58010 11.29080  35.09620  1.000 108.28719 ? 97  GLN B OE1 1 
ATOM   2943 N  NE2 . GLN B 1 98  ? -41.77206 10.01732  33.25695  1.000 104.80473 ? 97  GLN B NE2 1 
ATOM   2944 N  N   . GLU B 1 99  ? -37.72180 5.82473   35.64841  1.000 95.12021  ? 98  GLU B N   1 
ATOM   2945 C  CA  . GLU B 1 99  ? -36.86413 4.79768   35.08139  1.000 93.29309  ? 98  GLU B CA  1 
ATOM   2946 C  C   . GLU B 1 99  ? -36.74596 3.63484   36.05527  1.000 92.29522  ? 98  GLU B C   1 
ATOM   2947 O  O   . GLU B 1 99  ? -36.97851 3.78062   37.25722  1.000 96.83692  ? 98  GLU B O   1 
ATOM   2948 C  CB  . GLU B 1 99  ? -35.47527 5.35717   34.75704  1.000 98.84064  ? 98  GLU B CB  1 
ATOM   2949 C  CG  . GLU B 1 99  ? -35.48900 6.52874   33.79730  1.000 91.36721  ? 98  GLU B CG  1 
ATOM   2950 C  CD  . GLU B 1 99  ? -36.07031 6.15899   32.45389  1.000 93.98163  ? 98  GLU B CD  1 
ATOM   2951 O  OE1 . GLU B 1 99  ? -35.75576 5.06042   31.95316  1.000 97.14401  ? 98  GLU B OE1 1 
ATOM   2952 O  OE2 . GLU B 1 99  ? -36.85671 6.95622   31.90383  1.000 97.99570  ? 98  GLU B OE2 1 
ATOM   2953 N  N   . SER B 1 100 ? -36.38355 2.47140   35.51998  1.000 93.33927  ? 99  SER B N   1 
ATOM   2954 C  CA  . SER B 1 100 ? -36.23077 1.29206   36.35600  1.000 93.29116  ? 99  SER B CA  1 
ATOM   2955 C  C   . SER B 1 100 ? -35.08754 1.50367   37.34951  1.000 94.54491  ? 99  SER B C   1 
ATOM   2956 O  O   . SER B 1 100 ? -34.13601 2.23690   37.06522  1.000 93.78384  ? 99  SER B O   1 
ATOM   2957 C  CB  . SER B 1 100 ? -35.96588 0.05162   35.50279  1.000 96.15923  ? 99  SER B CB  1 
ATOM   2958 O  OG  . SER B 1 100 ? -34.57845 -0.20453  35.38369  1.000 97.21199  ? 99  SER B OG  1 
ATOM   2959 N  N   . PRO B 1 101 ? -35.17635 0.89825   38.54129  1.000 96.49108  ? 100 PRO B N   1 
ATOM   2960 C  CA  . PRO B 1 101 ? -34.13670 1.08984   39.56517  1.000 94.30926  ? 100 PRO B CA  1 
ATOM   2961 C  C   . PRO B 1 101 ? -32.71105 0.92831   39.05178  1.000 91.47445  ? 100 PRO B C   1 
ATOM   2962 O  O   . PRO B 1 101 ? -31.84295 1.75996   39.34930  1.000 94.40928  ? 100 PRO B O   1 
ATOM   2963 C  CB  . PRO B 1 101 ? -34.48320 0.01218   40.59824  1.000 95.07826  ? 100 PRO B CB  1 
ATOM   2964 C  CG  . PRO B 1 101 ? -35.97076 -0.10671  40.50653  1.000 95.78337  ? 100 PRO B CG  1 
ATOM   2965 C  CD  . PRO B 1 101 ? -36.32746 0.13289   39.05487  1.000 94.97853  ? 100 PRO B CD  1 
ATOM   2966 N  N   . GLU B 1 102 ? -32.45664 -0.12820  38.27436  1.000 89.89305  ? 101 GLU B N   1 
ATOM   2967 C  CA  . GLU B 1 102 ? -31.11725 -0.31771  37.72572  1.000 88.74321  ? 101 GLU B CA  1 
ATOM   2968 C  C   . GLU B 1 102 ? -30.75994 0.79801   36.75044  1.000 85.69364  ? 101 GLU B C   1 
ATOM   2969 O  O   . GLU B 1 102 ? -29.60894 1.25575   36.71669  1.000 81.73984  ? 101 GLU B O   1 
ATOM   2970 C  CB  . GLU B 1 102 ? -31.00274 -1.68155  37.04393  1.000 79.04095  ? 101 GLU B CB  1 
ATOM   2971 C  CG  . GLU B 1 102 ? -29.58582 -2.00930  36.58311  1.000 81.86405  ? 101 GLU B CG  1 
ATOM   2972 C  CD  . GLU B 1 102 ? -29.47063 -3.36376  35.90561  1.000 90.21038  ? 101 GLU B CD  1 
ATOM   2973 O  OE1 . GLU B 1 102 ? -30.48296 -4.09489  35.84869  1.000 89.65454  ? 101 GLU B OE1 1 
ATOM   2974 O  OE2 . GLU B 1 102 ? -28.36333 -3.69786  35.42857  1.000 90.05160  ? 101 GLU B OE2 1 
ATOM   2975 N  N   . ILE B 1 103 ? -31.72826 1.24337   35.94344  1.000 90.66208  ? 102 ILE B N   1 
ATOM   2976 C  CA  . ILE B 1 103 ? -31.48731 2.38614   35.06687  1.000 84.48096  ? 102 ILE B CA  1 
ATOM   2977 C  C   . ILE B 1 103 ? -31.07741 3.59378   35.89592  1.000 84.97565  ? 102 ILE B C   1 
ATOM   2978 O  O   . ILE B 1 103 ? -30.12383 4.30464   35.56001  1.000 80.14418  ? 102 ILE B O   1 
ATOM   2979 C  CB  . ILE B 1 103 ? -32.72765 2.69674   34.20710  1.000 86.46059  ? 102 ILE B CB  1 
ATOM   2980 C  CG1 . ILE B 1 103 ? -33.06044 1.54517   33.25949  1.000 88.30761  ? 102 ILE B CG1 1 
ATOM   2981 C  CG2 . ILE B 1 103 ? -32.50773 3.98537   33.41067  1.000 86.49922  ? 102 ILE B CG2 1 
ATOM   2982 C  CD1 . ILE B 1 103 ? -34.22679 1.84641   32.34068  1.000 87.07867  ? 102 ILE B CD1 1 
ATOM   2983 N  N   . GLN B 1 104 ? -31.79318 3.83937   36.99652  1.000 91.40939  ? 103 GLN B N   1 
ATOM   2984 C  CA  . GLN B 1 104 ? -31.46140 4.96689   37.85948  1.000 86.94506  ? 103 GLN B CA  1 
ATOM   2985 C  C   . GLN B 1 104 ? -30.03178 4.86390   38.36852  1.000 75.30146  ? 103 GLN B C   1 
ATOM   2986 O  O   . GLN B 1 104 ? -29.26923 5.83599   38.30690  1.000 72.87902  ? 103 GLN B O   1 
ATOM   2987 C  CB  . GLN B 1 104 ? -32.43107 5.03052   39.03469  1.000 84.38627  ? 103 GLN B CB  1 
ATOM   2988 C  CG  . GLN B 1 104 ? -33.87518 5.22554   38.64861  1.000 88.89464  ? 103 GLN B CG  1 
ATOM   2989 C  CD  . GLN B 1 104 ? -34.77764 5.27537   39.85887  1.000 93.91576  ? 103 GLN B CD  1 
ATOM   2990 O  OE1 . GLN B 1 104 ? -34.67253 6.17497   40.69335  1.000 83.48965  ? 103 GLN B OE1 1 
ATOM   2991 N  NE2 . GLN B 1 104 ? -35.66174 4.29349   39.97244  1.000 101.32546 ? 103 GLN B NE2 1 
ATOM   2992 N  N   . ALA B 1 105 ? -29.64796 3.68489   38.87129  1.000 73.44684  ? 104 ALA B N   1 
ATOM   2993 C  CA  . ALA B 1 105 ? -28.30256 3.53399   39.41788  1.000 77.75780  ? 104 ALA B CA  1 
ATOM   2994 C  C   . ALA B 1 105 ? -27.24176 3.79501   38.35409  1.000 69.31578  ? 104 ALA B C   1 
ATOM   2995 O  O   . ALA B 1 105 ? -26.29336 4.56109   38.58156  1.000 67.13013  ? 104 ALA B O   1 
ATOM   2996 C  CB  . ALA B 1 105 ? -28.12872 2.13818   40.01090  1.000 73.29279  ? 104 ALA B CB  1 
ATOM   2997 N  N   . ARG B 1 106 ? -27.39909 3.18864   37.17438  1.000 78.80139  ? 105 ARG B N   1 
ATOM   2998 C  CA  . ARG B 1 106 ? -26.41118 3.37575   36.11439  1.000 72.96153  ? 105 ARG B CA  1 
ATOM   2999 C  C   . ARG B 1 106 ? -26.31542 4.84138   35.70360  1.000 66.13911  ? 105 ARG B C   1 
ATOM   3000 O  O   . ARG B 1 106 ? -25.20938 5.40263   35.60541  1.000 68.85521  ? 105 ARG B O   1 
ATOM   3001 C  CB  . ARG B 1 106 ? -26.77058 2.49843   34.91303  1.000 71.99753  ? 105 ARG B CB  1 
ATOM   3002 C  CG  . ARG B 1 106 ? -26.82248 1.00927   35.22492  1.000 74.64335  ? 105 ARG B CG  1 
ATOM   3003 C  CD  . ARG B 1 106 ? -25.43255 0.39363   35.23786  1.000 75.06150  ? 105 ARG B CD  1 
ATOM   3004 N  NE  . ARG B 1 106 ? -24.78779 0.55524   33.94131  1.000 78.71326  ? 105 ARG B NE  1 
ATOM   3005 C  CZ  . ARG B 1 106 ? -24.99750 -0.23615  32.89775  1.000 79.41586  ? 105 ARG B CZ  1 
ATOM   3006 N  NH1 . ARG B 1 106 ? -25.78825 -1.29565  32.97973  1.000 82.94617  ? 105 ARG B NH1 1 
ATOM   3007 N  NH2 . ARG B 1 106 ? -24.40599 0.04685   31.74032  1.000 74.40027  ? 105 ARG B NH2 1 
ATOM   3008 N  N   . VAL B 1 107 ? -27.46672 5.49004   35.50395  1.000 68.65668  ? 106 VAL B N   1 
ATOM   3009 C  CA  . VAL B 1 107 ? -27.46851 6.88544   35.07886  1.000 67.67917  ? 106 VAL B CA  1 
ATOM   3010 C  C   . VAL B 1 107 ? -26.79405 7.75801   36.12358  1.000 64.88793  ? 106 VAL B C   1 
ATOM   3011 O  O   . VAL B 1 107 ? -26.04750 8.67937   35.78703  1.000 65.26751  ? 106 VAL B O   1 
ATOM   3012 C  CB  . VAL B 1 107 ? -28.89740 7.37908   34.79540  1.000 67.73563  ? 106 VAL B CB  1 
ATOM   3013 C  CG1 . VAL B 1 107 ? -28.85449 8.85519   34.44743  1.000 68.36976  ? 106 VAL B CG1 1 
ATOM   3014 C  CG2 . VAL B 1 107 ? -29.52314 6.60923   33.65635  1.000 71.53916  ? 106 VAL B CG2 1 
ATOM   3015 N  N   . LEU B 1 108 ? -27.09845 7.52531   37.40412  1.000 63.19538  ? 107 LEU B N   1 
ATOM   3016 C  CA  . LEU B 1 108 ? -26.50888 8.34715   38.45684  1.000 61.55949  ? 107 LEU B CA  1 
ATOM   3017 C  C   . LEU B 1 108 ? -24.99600 8.18598   38.49922  1.000 59.38818  ? 107 LEU B C   1 
ATOM   3018 O  O   . LEU B 1 108 ? -24.26612 9.16692   38.69414  1.000 60.17501  ? 107 LEU B O   1 
ATOM   3019 C  CB  . LEU B 1 108 ? -27.12242 7.99769   39.81092  1.000 62.76330  ? 107 LEU B CB  1 
ATOM   3020 C  CG  . LEU B 1 108 ? -28.59826 8.36414   39.98513  1.000 60.49640  ? 107 LEU B CG  1 
ATOM   3021 C  CD1 . LEU B 1 108 ? -29.15051 7.78445   41.27842  1.000 56.35274  ? 107 LEU B CD1 1 
ATOM   3022 C  CD2 . LEU B 1 108 ? -28.80987 9.87263   39.93066  1.000 55.08794  ? 107 LEU B CD2 1 
ATOM   3023 N  N   . VAL B 1 109 ? -24.50417 6.95793   38.30917  1.000 56.19699  ? 108 VAL B N   1 
ATOM   3024 C  CA  . VAL B 1 109 ? -23.05863 6.75551   38.22575  1.000 57.67162  ? 108 VAL B CA  1 
ATOM   3025 C  C   . VAL B 1 109 ? -22.47046 7.62534   37.11863  1.000 62.38347  ? 108 VAL B C   1 
ATOM   3026 O  O   . VAL B 1 109 ? -21.48612 8.34798   37.32530  1.000 63.19343  ? 108 VAL B O   1 
ATOM   3027 C  CB  . VAL B 1 109 ? -22.73353 5.26508   38.01091  1.000 56.15986  ? 108 VAL B CB  1 
ATOM   3028 C  CG1 . VAL B 1 109 ? -21.23732 5.07345   37.80146  1.000 61.35312  ? 108 VAL B CG1 1 
ATOM   3029 C  CG2 . VAL B 1 109 ? -23.21908 4.43256   39.19444  1.000 55.84656  ? 108 VAL B CG2 1 
ATOM   3030 N  N   . ILE B 1 110 ? -23.09640 7.59977   35.93848  1.000 56.16445  ? 109 ILE B N   1 
ATOM   3031 C  CA  . ILE B 1 110 ? -22.56047 8.33473   34.78667  1.000 62.75508  ? 109 ILE B CA  1 
ATOM   3032 C  C   . ILE B 1 110 ? -22.65027 9.84825   35.00516  1.000 59.16647  ? 109 ILE B C   1 
ATOM   3033 O  O   . ILE B 1 110 ? -21.73716 10.61124  34.64359  1.000 61.03228  ? 109 ILE B O   1 
ATOM   3034 C  CB  . ILE B 1 110 ? -23.28978 7.90333   33.50173  1.000 61.80252  ? 109 ILE B CB  1 
ATOM   3035 C  CG1 . ILE B 1 110 ? -22.93151 6.46007   33.14611  1.000 64.16664  ? 109 ILE B CG1 1 
ATOM   3036 C  CG2 . ILE B 1 110 ? -22.96852 8.84483   32.35633  1.000 45.82651  ? 109 ILE B CG2 1 
ATOM   3037 C  CD1 . ILE B 1 110 ? -24.04800 5.71511   32.45170  1.000 64.27871  ? 109 ILE B CD1 1 
ATOM   3038 N  N   . LEU B 1 111 ? -23.77758 10.30743  35.55198  1.000 58.50388  ? 110 LEU B N   1 
ATOM   3039 C  CA  . LEU B 1 111 ? -23.97016 11.72659  35.82811  1.000 61.91512  ? 110 LEU B CA  1 
ATOM   3040 C  C   . LEU B 1 111 ? -22.91878 12.23785  36.79999  1.000 64.42696  ? 110 LEU B C   1 
ATOM   3041 O  O   . LEU B 1 111 ? -22.33741 13.31251  36.60533  1.000 66.43988  ? 110 LEU B O   1 
ATOM   3042 C  CB  . LEU B 1 111 ? -25.36897 11.96979  36.39342  1.000 58.24261  ? 110 LEU B CB  1 
ATOM   3043 C  CG  . LEU B 1 111 ? -26.58649 11.92200  35.47050  1.000 62.55696  ? 110 LEU B CG  1 
ATOM   3044 C  CD1 . LEU B 1 111 ? -27.83279 12.28726  36.25763  1.000 59.76582  ? 110 LEU B CD1 1 
ATOM   3045 C  CD2 . LEU B 1 111 ? -26.40645 12.86256  34.29324  1.000 62.39840  ? 110 LEU B CD2 1 
ATOM   3046 N  N   . ASN B 1 112 ? -22.66901 11.47730  37.86713  1.000 59.02243  ? 111 ASN B N   1 
ATOM   3047 C  CA  . ASN B 1 112 ? -21.61981 11.85540  38.80278  1.000 67.13429  ? 111 ASN B CA  1 
ATOM   3048 C  C   . ASN B 1 112 ? -20.25900 11.84548  38.12533  1.000 65.16510  ? 111 ASN B C   1 
ATOM   3049 O  O   . ASN B 1 112 ? -19.43071 12.72211  38.38296  1.000 65.35558  ? 111 ASN B O   1 
ATOM   3050 C  CB  . ASN B 1 112 ? -21.63919 10.92994  40.01869  1.000 59.93056  ? 111 ASN B CB  1 
ATOM   3051 C  CG  . ASN B 1 112 ? -22.78701 11.23298  40.95398  1.000 62.79737  ? 111 ASN B CG  1 
ATOM   3052 O  OD1 . ASN B 1 112 ? -22.79849 12.27211  41.61468  1.000 72.01672  ? 111 ASN B OD1 1 
ATOM   3053 N  ND2 . ASN B 1 112 ? -23.75472 10.32512  41.02624  1.000 49.51244  ? 111 ASN B ND2 1 
ATOM   3054 N  N   . ASN B 1 113 ? -20.02136 10.87967  37.23264  1.000 55.88755  ? 112 ASN B N   1 
ATOM   3055 C  CA  . ASN B 1 113 ? -18.75427 10.84835  36.50920  1.000 64.17095  ? 112 ASN B CA  1 
ATOM   3056 C  C   . ASN B 1 113 ? -18.52782 12.13912  35.73587  1.000 65.73839  ? 112 ASN B C   1 
ATOM   3057 O  O   . ASN B 1 113 ? -17.41379 12.67942  35.72919  1.000 64.37164  ? 112 ASN B O   1 
ATOM   3058 C  CB  . ASN B 1 113 ? -18.71536 9.64810   35.56532  1.000 60.74122  ? 112 ASN B CB  1 
ATOM   3059 C  CG  . ASN B 1 113 ? -18.40622 8.35455   36.28742  1.000 67.91971  ? 112 ASN B CG  1 
ATOM   3060 O  OD1 . ASN B 1 113 ? -17.44864 8.26839   37.06047  1.000 68.26395  ? 112 ASN B OD1 1 
ATOM   3061 N  ND2 . ASN B 1 113 ? -19.22479 7.34119   36.04877  1.000 71.69240  ? 112 ASN B ND2 1 
ATOM   3062 N  N   . TYR B 1 114 ? -19.57159 12.65233  35.07960  1.000 59.78333  ? 113 TYR B N   1 
ATOM   3063 C  CA  . TYR B 1 114 ? -19.37296 13.88729  34.32720  1.000 66.81739  ? 113 TYR B CA  1 
ATOM   3064 C  C   . TYR B 1 114 ? -19.29634 15.10483  35.24024  1.000 65.44061  ? 113 TYR B C   1 
ATOM   3065 O  O   . TYR B 1 114 ? -18.59944 16.07065  34.91112  1.000 62.54452  ? 113 TYR B O   1 
ATOM   3066 C  CB  . TYR B 1 114 ? -20.46263 14.08232  33.27439  1.000 61.49380  ? 113 TYR B CB  1 
ATOM   3067 C  CG  . TYR B 1 114 ? -20.01549 15.01793  32.17246  1.000 63.82946  ? 113 TYR B CG  1 
ATOM   3068 C  CD1 . TYR B 1 114 ? -19.03463 14.63030  31.27074  1.000 56.54069  ? 113 TYR B CD1 1 
ATOM   3069 C  CD2 . TYR B 1 114 ? -20.54893 16.29367  32.04943  1.000 62.85022  ? 113 TYR B CD2 1 
ATOM   3070 C  CE1 . TYR B 1 114 ? -18.60909 15.47789  30.26642  1.000 57.31886  ? 113 TYR B CE1 1 
ATOM   3071 C  CE2 . TYR B 1 114 ? -20.12887 17.15044  31.04479  1.000 57.04520  ? 113 TYR B CE2 1 
ATOM   3072 C  CZ  . TYR B 1 114 ? -19.15984 16.73872  30.15698  1.000 58.70835  ? 113 TYR B CZ  1 
ATOM   3073 O  OH  . TYR B 1 114 ? -18.74251 17.59043  29.16079  1.000 50.91814  ? 113 TYR B OH  1 
ATOM   3074 N  N   . TYR B 1 115 ? -19.99380 15.07977  36.38076  1.000 67.05832  ? 114 TYR B N   1 
ATOM   3075 C  CA  . TYR B 1 115 ? -19.85043 16.15966  37.35535  1.000 63.47894  ? 114 TYR B CA  1 
ATOM   3076 C  C   . TYR B 1 115 ? -18.43783 16.21044  37.92561  1.000 65.70880  ? 114 TYR B C   1 
ATOM   3077 O  O   . TYR B 1 115 ? -17.93348 17.29468  38.24185  1.000 79.27598  ? 114 TYR B O   1 
ATOM   3078 C  CB  . TYR B 1 115 ? -20.88110 15.99339  38.47445  1.000 67.98834  ? 114 TYR B CB  1 
ATOM   3079 C  CG  . TYR B 1 115 ? -20.93955 17.12154  39.48985  1.000 68.98815  ? 114 TYR B CG  1 
ATOM   3080 C  CD1 . TYR B 1 115 ? -21.25718 18.42012  39.10795  1.000 70.61870  ? 114 TYR B CD1 1 
ATOM   3081 C  CD2 . TYR B 1 115 ? -20.71880 16.87621  40.83784  1.000 72.99593  ? 114 TYR B CD2 1 
ATOM   3082 C  CE1 . TYR B 1 115 ? -21.32683 19.44794  40.04315  1.000 73.45028  ? 114 TYR B CE1 1 
ATOM   3083 C  CE2 . TYR B 1 115 ? -20.78813 17.89536  41.77756  1.000 74.35795  ? 114 TYR B CE2 1 
ATOM   3084 C  CZ  . TYR B 1 115 ? -21.09219 19.17861  41.37608  1.000 74.87097  ? 114 TYR B CZ  1 
ATOM   3085 O  OH  . TYR B 1 115 ? -21.16126 20.19038  42.30962  1.000 70.69009  ? 114 TYR B OH  1 
ATOM   3086 N  N   . GLN B 1 116 ? -17.78957 15.05165  38.07396  1.000 65.17431  ? 115 GLN B N   1 
ATOM   3087 C  CA  . GLN B 1 116 ? -16.40934 15.03097  38.54340  1.000 70.53557  ? 115 GLN B CA  1 
ATOM   3088 C  C   . GLN B 1 116 ? -15.44708 15.48968  37.45713  1.000 69.94370  ? 115 GLN B C   1 
ATOM   3089 O  O   . GLN B 1 116 ? -14.42756 16.11817  37.76168  1.000 75.43995  ? 115 GLN B O   1 
ATOM   3090 C  CB  . GLN B 1 116 ? -16.01905 13.62718  39.01830  1.000 68.91006  ? 115 GLN B CB  1 
ATOM   3091 C  CG  . GLN B 1 116 ? -16.98874 12.96329  39.98954  1.000 72.28885  ? 115 GLN B CG  1 
ATOM   3092 C  CD  . GLN B 1 116 ? -17.17430 13.73549  41.27777  1.000 78.05798  ? 115 GLN B CD  1 
ATOM   3093 O  OE1 . GLN B 1 116 ? -18.30008 14.02063  41.69168  1.000 76.88919  ? 115 GLN B OE1 1 
ATOM   3094 N  NE2 . GLN B 1 116 ? -16.06696 14.06278  41.93147  1.000 78.71840  ? 115 GLN B NE2 1 
ATOM   3095 N  N   . GLN B 1 117 ? -15.74565 15.18252  36.19503  1.000 68.56638  ? 116 GLN B N   1 
ATOM   3096 C  CA  . GLN B 1 117 ? -14.85572 15.48581  35.07348  1.000 75.24349  ? 116 GLN B CA  1 
ATOM   3097 C  C   . GLN B 1 117 ? -15.68496 15.85502  33.85262  1.000 64.75172  ? 116 GLN B C   1 
ATOM   3098 O  O   . GLN B 1 117 ? -15.95587 15.01495  32.98608  1.000 64.53413  ? 116 GLN B O   1 
ATOM   3099 C  CB  . GLN B 1 117 ? -13.94016 14.29793  34.76601  1.000 74.86725  ? 116 GLN B CB  1 
ATOM   3100 C  CG  . GLN B 1 117 ? -12.87606 14.02867  35.81425  1.000 79.64009  ? 116 GLN B CG  1 
ATOM   3101 C  CD  . GLN B 1 117 ? -12.13779 12.72573  35.57606  1.000 92.61239  ? 116 GLN B CD  1 
ATOM   3102 O  OE1 . GLN B 1 117 ? -12.64474 11.82119  34.91392  1.000 92.92015  ? 116 GLN B OE1 1 
ATOM   3103 N  NE2 . GLN B 1 117 ? -10.93174 12.62367  36.11965  1.000 102.48316 ? 116 GLN B NE2 1 
ATOM   3104 N  N   . PRO B 1 118 ? -16.12160 17.11528  33.75450  1.000 69.92657  ? 117 PRO B N   1 
ATOM   3105 C  CA  . PRO B 1 118 ? -16.77975 17.56361  32.51939  1.000 63.05415  ? 117 PRO B CA  1 
ATOM   3106 C  C   . PRO B 1 118 ? -15.75571 17.77378  31.41865  1.000 62.81372  ? 117 PRO B C   1 
ATOM   3107 O  O   . PRO B 1 118 ? -15.01512 18.76316  31.42996  1.000 63.25579  ? 117 PRO B O   1 
ATOM   3108 C  CB  . PRO B 1 118 ? -17.45063 18.88680  32.92450  1.000 63.75090  ? 117 PRO B CB  1 
ATOM   3109 C  CG  . PRO B 1 118 ? -17.36294 18.93741  34.43562  1.000 65.40017  ? 117 PRO B CG  1 
ATOM   3110 C  CD  . PRO B 1 118 ? -16.14279 18.15646  34.78924  1.000 68.43304  ? 117 PRO B CD  1 
ATOM   3111 N  N   . ILE B 1 119 ? -15.71353 16.84952  30.45572  1.000 60.51754  ? 118 ILE B N   1 
ATOM   3112 C  CA  . ILE B 1 119 ? -14.64681 16.85663  29.46356  1.000 62.01041  ? 118 ILE B CA  1 
ATOM   3113 C  C   . ILE B 1 119 ? -14.84550 17.93777  28.41235  1.000 55.73242  ? 118 ILE B C   1 
ATOM   3114 O  O   . ILE B 1 119 ? -13.87251 18.37001  27.78533  1.000 60.72451  ? 118 ILE B O   1 
ATOM   3115 C  CB  . ILE B 1 119 ? -14.52527 15.47307  28.79836  1.000 61.92759  ? 118 ILE B CB  1 
ATOM   3116 C  CG1 . ILE B 1 119 ? -15.80046 15.14489  28.01446  1.000 58.91003  ? 118 ILE B CG1 1 
ATOM   3117 C  CG2 . ILE B 1 119 ? -14.24311 14.40527  29.85254  1.000 55.33325  ? 118 ILE B CG2 1 
ATOM   3118 C  CD1 . ILE B 1 119 ? -15.65775 13.97847  27.06005  1.000 66.94948  ? 118 ILE B CD1 1 
ATOM   3119 N  N   . LEU B 1 120 ? -16.07741 18.39564  28.20314  1.000 51.45031  ? 119 LEU B N   1 
ATOM   3120 C  CA  . LEU B 1 120 ? -16.35914 19.40368  27.19200  1.000 62.30767  ? 119 LEU B CA  1 
ATOM   3121 C  C   . LEU B 1 120 ? -16.32535 20.82759  27.73379  1.000 63.06406  ? 119 LEU B C   1 
ATOM   3122 O  O   . LEU B 1 120 ? -16.38995 21.77315  26.94194  1.000 60.82816  ? 119 LEU B O   1 
ATOM   3123 C  CB  . LEU B 1 120 ? -17.72400 19.12992  26.54500  1.000 57.65079  ? 119 LEU B CB  1 
ATOM   3124 C  CG  . LEU B 1 120 ? -17.84350 17.81279  25.77415  1.000 64.33006  ? 119 LEU B CG  1 
ATOM   3125 C  CD1 . LEU B 1 120 ? -19.26141 17.60631  25.25539  1.000 55.75697  ? 119 LEU B CD1 1 
ATOM   3126 C  CD2 . LEU B 1 120 ? -16.84484 17.77827  24.62873  1.000 58.61447  ? 119 LEU B CD2 1 
ATOM   3127 N  N   . LEU B 1 121 ? -16.21833 21.00456  29.05347  1.000 54.76506  ? 120 LEU B N   1 
ATOM   3128 C  CA  . LEU B 1 121 ? -16.12779 22.34861  29.61542  1.000 62.52885  ? 120 LEU B CA  1 
ATOM   3129 C  C   . LEU B 1 121 ? -14.85543 23.05361  29.16000  1.000 58.94509  ? 120 LEU B C   1 
ATOM   3130 O  O   . LEU B 1 121 ? -14.86940 24.26613  28.91916  1.000 60.82884  ? 120 LEU B O   1 
ATOM   3131 C  CB  . LEU B 1 121 ? -16.19598 22.28026  31.14547  1.000 59.66480  ? 120 LEU B CB  1 
ATOM   3132 C  CG  . LEU B 1 121 ? -16.16430 23.59865  31.92537  1.000 67.63984  ? 120 LEU B CG  1 
ATOM   3133 C  CD1 . LEU B 1 121 ? -17.26785 24.52757  31.45112  1.000 66.42242  ? 120 LEU B CD1 1 
ATOM   3134 C  CD2 . LEU B 1 121 ? -16.27763 23.34972  33.42225  1.000 59.48553  ? 120 LEU B CD2 1 
ATOM   3135 N  N   . ASN B 1 122 ? -13.75465 22.30963  29.02924  1.000 64.86744  ? 121 ASN B N   1 
ATOM   3136 C  CA  . ASN B 1 122 ? -12.50290 22.87050  28.53826  1.000 68.91878  ? 121 ASN B CA  1 
ATOM   3137 C  C   . ASN B 1 122 ? -12.59026 23.27468  27.07488  1.000 76.55571  ? 121 ASN B C   1 
ATOM   3138 O  O   . ASN B 1 122 ? -11.79943 24.11115  26.62746  1.000 80.38703  ? 121 ASN B O   1 
ATOM   3139 C  CB  . ASN B 1 122 ? -11.37413 21.85155  28.72172  1.000 73.49014  ? 121 ASN B CB  1 
ATOM   3140 C  CG  . ASN B 1 122 ? -9.99603  22.47690  28.63773  1.000 86.64586  ? 121 ASN B CG  1 
ATOM   3141 O  OD1 . ASN B 1 122 ? -9.51897  22.81851  27.55373  1.000 101.80232 ? 121 ASN B OD1 1 
ATOM   3142 N  ND2 . ASN B 1 122 ? -9.33764  22.60640  29.78055  1.000 87.34764  ? 121 ASN B ND2 1 
ATOM   3143 N  N   . LYS B 1 123 ? -13.53882 22.71592  26.33115  1.000 78.22462  ? 122 LYS B N   1 
ATOM   3144 C  CA  . LYS B 1 123 ? -13.52337 22.74936  24.87776  1.000 70.38726  ? 122 LYS B CA  1 
ATOM   3145 C  C   . LYS B 1 123 ? -14.54312 23.73984  24.32557  1.000 72.04659  ? 122 LYS B C   1 
ATOM   3146 O  O   . LYS B 1 123 ? -15.51819 24.10353  24.98640  1.000 71.93479  ? 122 LYS B O   1 
ATOM   3147 C  CB  . LYS B 1 123 ? -13.79669 21.35317  24.31550  1.000 69.84843  ? 122 LYS B CB  1 
ATOM   3148 C  CG  . LYS B 1 123 ? -13.16403 20.21538  25.10311  1.000 71.23870  ? 122 LYS B CG  1 
ATOM   3149 C  CD  . LYS B 1 123 ? -11.64852 20.22661  24.98079  1.000 70.97950  ? 122 LYS B CD  1 
ATOM   3150 C  CE  . LYS B 1 123 ? -11.04662 18.87181  25.34137  1.000 71.90875  ? 122 LYS B CE  1 
ATOM   3151 N  NZ  . LYS B 1 123 ? -11.17773 18.55201  26.78877  1.000 64.81209  ? 122 LYS B NZ  1 
ATOM   3152 N  N   . GLU B 1 124 ? -14.29679 24.17212  23.08850  1.000 64.21671  ? 123 GLU B N   1 
ATOM   3153 C  CA  . GLU B 1 124 ? -15.16884 25.10760  22.37535  1.000 66.15415  ? 123 GLU B CA  1 
ATOM   3154 C  C   . GLU B 1 124 ? -16.19676 24.29653  21.59177  1.000 64.21657  ? 123 GLU B C   1 
ATOM   3155 O  O   . GLU B 1 124 ? -15.87400 23.69311  20.56636  1.000 60.93649  ? 123 GLU B O   1 
ATOM   3156 C  CB  . GLU B 1 124 ? -14.34305 26.00758  21.46025  1.000 65.66319  ? 123 GLU B CB  1 
ATOM   3157 C  CG  . GLU B 1 124 ? -15.14562 26.83419  20.46724  1.000 66.43197  ? 123 GLU B CG  1 
ATOM   3158 C  CD  . GLU B 1 124 ? -14.25908 27.55316  19.46336  1.000 78.36204  ? 123 GLU B CD  1 
ATOM   3159 O  OE1 . GLU B 1 124 ? -13.02393 27.56878  19.65455  1.000 72.28025  ? 123 GLU B OE1 1 
ATOM   3160 O  OE2 . GLU B 1 124 ? -14.79232 28.09985  18.47639  1.000 80.21691  ? 123 GLU B OE2 1 
ATOM   3161 N  N   . ILE B 1 125 ? -17.44094 24.29184  22.06478  1.000 63.98558  ? 124 ILE B N   1 
ATOM   3162 C  CA  . ILE B 1 125 ? -18.46727 23.39338  21.54236  1.000 55.63777  ? 124 ILE B CA  1 
ATOM   3163 C  C   . ILE B 1 125 ? -19.09414 24.01816  20.29806  1.000 53.13925  ? 124 ILE B C   1 
ATOM   3164 O  O   . ILE B 1 125 ? -19.73783 25.06826  20.37477  1.000 62.70710  ? 124 ILE B O   1 
ATOM   3165 C  CB  . ILE B 1 125 ? -19.52995 23.09038  22.60372  1.000 56.52248  ? 124 ILE B CB  1 
ATOM   3166 C  CG1 . ILE B 1 125 ? -18.86769 22.63194  23.90387  1.000 58.85476  ? 124 ILE B CG1 1 
ATOM   3167 C  CG2 . ILE B 1 125 ? -20.48565 22.02886  22.10775  1.000 63.87897  ? 124 ILE B CG2 1 
ATOM   3168 C  CD1 . ILE B 1 125 ? -19.85498 22.28064  25.00101  1.000 55.41838  ? 124 ILE B CD1 1 
ATOM   3169 N  N   . ILE B 1 126 ? -18.90300 23.37339  19.14374  1.000 60.30453  ? 125 ILE B N   1 
ATOM   3170 C  CA  . ILE B 1 126 ? -19.66260 23.75940  17.95918  1.000 52.52444  ? 125 ILE B CA  1 
ATOM   3171 C  C   . ILE B 1 126 ? -21.10146 23.27018  18.07093  1.000 53.45697  ? 125 ILE B C   1 
ATOM   3172 O  O   . ILE B 1 126 ? -22.04002 23.98870  17.71122  1.000 50.53373  ? 125 ILE B O   1 
ATOM   3173 C  CB  . ILE B 1 126 ? -18.97878 23.24091  16.67992  1.000 55.42551  ? 125 ILE B CB  1 
ATOM   3174 C  CG1 . ILE B 1 126 ? -17.52198 23.71101  16.61817  1.000 51.12580  ? 125 ILE B CG1 1 
ATOM   3175 C  CG2 . ILE B 1 126 ? -19.72851 23.70345  15.43358  1.000 51.86680  ? 125 ILE B CG2 1 
ATOM   3176 C  CD1 . ILE B 1 126 ? -16.86551 23.48073  15.27204  1.000 50.72743  ? 125 ILE B CD1 1 
ATOM   3177 N  N   . ASN B 1 127 ? -21.30517 22.05917  18.59522  1.000 53.05603  ? 126 ASN B N   1 
ATOM   3178 C  CA  . ASN B 1 127 ? -22.65809 21.55348  18.80254  1.000 56.31456  ? 126 ASN B CA  1 
ATOM   3179 C  C   . ASN B 1 127 ? -22.65104 20.39270  19.78925  1.000 58.77484  ? 126 ASN B C   1 
ATOM   3180 O  O   . ASN B 1 127 ? -21.74538 19.55682  19.76494  1.000 66.65233  ? 126 ASN B O   1 
ATOM   3181 C  CB  . ASN B 1 127 ? -23.29807 21.10034  17.48428  1.000 60.44060  ? 126 ASN B CB  1 
ATOM   3182 C  CG  . ASN B 1 127 ? -24.70124 20.56760  17.67632  1.000 72.62498  ? 126 ASN B CG  1 
ATOM   3183 O  OD1 . ASN B 1 127 ? -25.60112 21.28917  18.11273  1.000 69.49108  ? 126 ASN B OD1 1 
ATOM   3184 N  ND2 . ASN B 1 127 ? -24.89593 19.29507  17.35469  1.000 71.97240  ? 126 ASN B ND2 1 
ATOM   3185 N  N   . LEU B 1 128 ? -23.67713 20.34204  20.64127  1.000 51.09881  ? 127 LEU B N   1 
ATOM   3186 C  CA  . LEU B 1 128 ? -23.92826 19.20242  21.51416  1.000 51.09796  ? 127 LEU B CA  1 
ATOM   3187 C  C   . LEU B 1 128 ? -25.38315 18.78961  21.35635  1.000 54.85100  ? 127 LEU B C   1 
ATOM   3188 O  O   . LEU B 1 128 ? -26.28202 19.63329  21.41972  1.000 59.05756  ? 127 LEU B O   1 
ATOM   3189 C  CB  . LEU B 1 128 ? -23.62185 19.52361  22.98253  1.000 59.13238  ? 127 LEU B CB  1 
ATOM   3190 C  CG  . LEU B 1 128 ? -23.74354 18.33120  23.94045  1.000 53.57805  ? 127 LEU B CG  1 
ATOM   3191 C  CD1 . LEU B 1 128 ? -22.76102 17.23875  23.54953  1.000 53.45618  ? 127 LEU B CD1 1 
ATOM   3192 C  CD2 . LEU B 1 128 ? -23.52790 18.74388  25.38543  1.000 61.92508  ? 127 LEU B CD2 1 
ATOM   3193 N  N   . SER B 1 129 ? -25.61058 17.49879  21.14978  1.000 57.58060  ? 128 SER B N   1 
ATOM   3194 C  CA  . SER B 1 129 ? -26.94734 16.97277  20.91992  1.000 62.53747  ? 128 SER B CA  1 
ATOM   3195 C  C   . SER B 1 129 ? -27.57656 16.48239  22.21699  1.000 61.23058  ? 128 SER B C   1 
ATOM   3196 O  O   . SER B 1 129 ? -26.88446 16.03556  23.13489  1.000 55.44440  ? 128 SER B O   1 
ATOM   3197 C  CB  . SER B 1 129 ? -26.90311 15.82605  19.90832  1.000 59.67439  ? 128 SER B CB  1 
ATOM   3198 O  OG  . SER B 1 129 ? -28.03518 14.99009  20.05207  1.000 70.42799  ? 128 SER B OG  1 
ATOM   3199 N  N   . ARG B 1 130 ? -28.90553 16.57088  22.28375  1.000 62.12468  ? 129 ARG B N   1 
ATOM   3200 C  CA  . ARG B 1 130 ? -29.64529 15.97918  23.38925  1.000 66.75566  ? 129 ARG B CA  1 
ATOM   3201 C  C   . ARG B 1 130 ? -30.00378 14.51760  23.14915  1.000 74.25717  ? 129 ARG B C   1 
ATOM   3202 O  O   . ARG B 1 130 ? -30.49585 13.85701  24.07233  1.000 67.64245  ? 129 ARG B O   1 
ATOM   3203 C  CB  . ARG B 1 130 ? -30.91859 16.78365  23.68054  1.000 74.10753  ? 129 ARG B CB  1 
ATOM   3204 C  CG  . ARG B 1 130 ? -31.54810 17.45369  22.47902  1.000 78.04459  ? 129 ARG B CG  1 
ATOM   3205 C  CD  . ARG B 1 130 ? -32.70262 18.33636  22.91973  1.000 84.58084  ? 129 ARG B CD  1 
ATOM   3206 N  NE  . ARG B 1 130 ? -33.67336 17.57820  23.69932  1.000 81.23482  ? 129 ARG B NE  1 
ATOM   3207 C  CZ  . ARG B 1 130 ? -34.68352 18.11435  24.37169  1.000 78.22145  ? 129 ARG B CZ  1 
ATOM   3208 N  NH1 . ARG B 1 130 ? -34.87391 19.42339  24.41049  1.000 78.13428  ? 129 ARG B NH1 1 
ATOM   3209 N  NH2 . ARG B 1 130 ? -35.52716 17.31679  25.01965  1.000 76.47483  ? 129 ARG B NH2 1 
ATOM   3210 N  N   . GLY B 1 131 ? -29.76017 13.99719  21.94721  1.000 76.95459  ? 130 GLY B N   1 
ATOM   3211 C  CA  . GLY B 1 131 ? -29.99538 12.59810  21.66213  1.000 68.82621  ? 130 GLY B CA  1 
ATOM   3212 C  C   . GLY B 1 131 ? -31.39455 12.23711  21.22265  1.000 73.73021  ? 130 GLY B C   1 
ATOM   3213 O  O   . GLY B 1 131 ? -31.70533 11.04407  21.13359  1.000 75.79779  ? 130 GLY B O   1 
ATOM   3214 N  N   . ASP B 1 132 ? -32.25416 13.21499  20.95083  1.000 77.66788  ? 131 ASP B N   1 
ATOM   3215 C  CA  . ASP B 1 132 ? -33.58813 12.93353  20.44176  1.000 82.71165  ? 131 ASP B CA  1 
ATOM   3216 C  C   . ASP B 1 132 ? -33.80138 13.45669  19.02866  1.000 83.63125  ? 131 ASP B C   1 
ATOM   3217 O  O   . ASP B 1 132 ? -34.89137 13.27829  18.47283  1.000 84.25645  ? 131 ASP B O   1 
ATOM   3218 C  CB  . ASP B 1 132 ? -34.65688 13.50874  21.38190  1.000 81.92593  ? 131 ASP B CB  1 
ATOM   3219 C  CG  . ASP B 1 132 ? -34.48073 14.99258  21.63419  1.000 89.86940  ? 131 ASP B CG  1 
ATOM   3220 O  OD1 . ASP B 1 132 ? -33.59063 15.60287  21.01267  1.000 94.34113  ? 131 ASP B OD1 1 
ATOM   3221 O  OD2 . ASP B 1 132 ? -35.23329 15.55588  22.45972  1.000 89.99185  ? 131 ASP B OD2 1 
ATOM   3222 N  N   . GLU B 1 133 ? -32.79774 14.10473  18.43343  1.000 82.63573  ? 132 GLU B N   1 
ATOM   3223 C  CA  . GLU B 1 133 ? -32.96999 14.63021  17.08359  1.000 87.22280  ? 132 GLU B CA  1 
ATOM   3224 C  C   . GLU B 1 133 ? -32.92347 13.52332  16.03462  1.000 88.95665  ? 132 GLU B C   1 
ATOM   3225 O  O   . GLU B 1 133 ? -33.72295 13.52674  15.09147  1.000 88.75932  ? 132 GLU B O   1 
ATOM   3226 C  CB  . GLU B 1 133 ? -31.90929 15.69287  16.79190  1.000 85.60930  ? 132 GLU B CB  1 
ATOM   3227 C  CG  . GLU B 1 133 ? -31.86841 16.83312  17.79320  1.000 87.98130  ? 132 GLU B CG  1 
ATOM   3228 C  CD  . GLU B 1 133 ? -30.84709 16.61151  18.89226  1.000 88.93617  ? 132 GLU B CD  1 
ATOM   3229 O  OE1 . GLU B 1 133 ? -30.80607 15.50060  19.46454  1.000 87.92875  ? 132 GLU B OE1 1 
ATOM   3230 O  OE2 . GLU B 1 133 ? -30.08086 17.55318  19.18587  1.000 91.31750  ? 132 GLU B OE2 1 
ATOM   3231 N  N   . GLY B 1 134 ? -32.01105 12.56637  16.18719  1.000 91.68098  ? 133 GLY B N   1 
ATOM   3232 C  CA  . GLY B 1 134 ? -31.88640 11.48891  15.22451  1.000 91.90503  ? 133 GLY B CA  1 
ATOM   3233 C  C   . GLY B 1 134 ? -31.07442 11.88597  14.00280  1.000 91.91046  ? 133 GLY B C   1 
ATOM   3234 O  O   . GLY B 1 134 ? -30.38019 12.90752  13.98050  1.000 87.86154  ? 133 GLY B O   1 
ATOM   3235 N  N   . TYR B 1 135 ? -31.18502 11.06181  12.96395  1.000 77.85033  ? 134 TYR B N   1 
ATOM   3236 C  CA  . TYR B 1 135 ? -30.37672 11.24910  11.75966  1.000 76.98456  ? 134 TYR B CA  1 
ATOM   3237 C  C   . TYR B 1 135 ? -30.69963 12.58298  11.09230  1.000 74.05172  ? 134 TYR B C   1 
ATOM   3238 O  O   . TYR B 1 135 ? -31.87499 12.88069  10.84918  1.000 71.96484  ? 134 TYR B O   1 
ATOM   3239 C  CB  . TYR B 1 135 ? -30.61655 10.11240  10.76507  1.000 69.32780  ? 134 TYR B CB  1 
ATOM   3240 C  CG  . TYR B 1 135 ? -29.88385 8.83167   11.09609  1.000 68.46873  ? 134 TYR B CG  1 
ATOM   3241 C  CD1 . TYR B 1 135 ? -28.50420 8.81973   11.24091  1.000 66.51289  ? 134 TYR B CD1 1 
ATOM   3242 C  CD2 . TYR B 1 135 ? -30.56654 7.63251   11.24685  1.000 67.96315  ? 134 TYR B CD2 1 
ATOM   3243 C  CE1 . TYR B 1 135 ? -27.82437 7.65440   11.54197  1.000 66.25612  ? 134 TYR B CE1 1 
ATOM   3244 C  CE2 . TYR B 1 135 ? -29.89334 6.45981   11.54550  1.000 77.38112  ? 134 TYR B CE2 1 
ATOM   3245 C  CZ  . TYR B 1 135 ? -28.52256 6.47814   11.69210  1.000 76.13119  ? 134 TYR B CZ  1 
ATOM   3246 O  OH  . TYR B 1 135 ? -27.84907 5.31492   11.98796  1.000 70.50460  ? 134 TYR B OH  1 
ATOM   3247 N  N   . PRO B 1 136 ? -29.69274 13.39504  10.75134  1.000 74.09390  ? 135 PRO B N   1 
ATOM   3248 C  CA  . PRO B 1 136 ? -29.96754 14.67143  10.08131  1.000 71.26909  ? 135 PRO B CA  1 
ATOM   3249 C  C   . PRO B 1 136 ? -30.14793 14.51317  8.58064   1.000 71.45895  ? 135 PRO B C   1 
ATOM   3250 O  O   . PRO B 1 136 ? -30.32266 13.39779  8.07736   1.000 69.21147  ? 135 PRO B O   1 
ATOM   3251 C  CB  . PRO B 1 136 ? -28.72320 15.49965  10.40776  1.000 74.43675  ? 135 PRO B CB  1 
ATOM   3252 C  CG  . PRO B 1 136 ? -27.63208 14.47532  10.41088  1.000 82.82575  ? 135 PRO B CG  1 
ATOM   3253 C  CD  . PRO B 1 136 ? -28.24939 13.20437  10.98040  1.000 77.07612  ? 135 PRO B CD  1 
ATOM   3254 N  N   . GLU B 1 137 ? -30.14308 15.64188  7.86895   1.000 73.43667  ? 136 GLU B N   1 
ATOM   3255 C  CA  . GLU B 1 137 ? -30.14405 15.70116  6.41033   1.000 75.11275  ? 136 GLU B CA  1 
ATOM   3256 C  C   . GLU B 1 137 ? -29.16119 14.68932  5.83053   1.000 68.64654  ? 136 GLU B C   1 
ATOM   3257 O  O   . GLU B 1 137 ? -27.96513 14.73958  6.15038   1.000 69.09790  ? 136 GLU B O   1 
ATOM   3258 C  CB  . GLU B 1 137 ? -29.77304 17.11146  5.93557   1.000 68.95808  ? 136 GLU B CB  1 
ATOM   3259 C  CG  . GLU B 1 137 ? -29.69869 17.26665  4.43284   1.000 80.59101  ? 136 GLU B CG  1 
ATOM   3260 C  CD  . GLU B 1 137 ? -31.04602 17.08657  3.76682   1.000 97.32036  ? 136 GLU B CD  1 
ATOM   3261 O  OE1 . GLU B 1 137 ? -32.04697 17.60332  4.30329   1.000 96.04730  ? 136 GLU B OE1 1 
ATOM   3262 O  OE2 . GLU B 1 137 ? -31.11375 16.42111  2.71175   1.000 100.81786 ? 136 GLU B OE2 1 
ATOM   3263 N  N   . PRO B 1 138 ? -29.61302 13.74906  5.00142   1.000 61.60905  ? 137 PRO B N   1 
ATOM   3264 C  CA  . PRO B 1 138 ? -28.65876 12.87721  4.31188   1.000 62.77768  ? 137 PRO B CA  1 
ATOM   3265 C  C   . PRO B 1 138 ? -27.76876 13.70698  3.40247   1.000 62.53201  ? 137 PRO B C   1 
ATOM   3266 O  O   . PRO B 1 138 ? -28.20032 14.70981  2.83332   1.000 63.37910  ? 137 PRO B O   1 
ATOM   3267 C  CB  . PRO B 1 138 ? -29.55655 11.92105  3.51734   1.000 65.00452  ? 137 PRO B CB  1 
ATOM   3268 C  CG  . PRO B 1 138 ? -30.89526 12.00535  4.17560   1.000 67.96458  ? 137 PRO B CG  1 
ATOM   3269 C  CD  . PRO B 1 138 ? -31.00396 13.43140  4.63845   1.000 68.02176  ? 137 PRO B CD  1 
ATOM   3270 N  N   . ILE B 1 139 ? -26.51221 13.29904  3.28315   1.000 59.06268  ? 138 ILE B N   1 
ATOM   3271 C  CA  . ILE B 1 139 ? -25.57240 13.94216  2.37359   1.000 59.25458  ? 138 ILE B CA  1 
ATOM   3272 C  C   . ILE B 1 139 ? -25.28919 12.98105  1.22652   1.000 58.80754  ? 138 ILE B C   1 
ATOM   3273 O  O   . ILE B 1 139 ? -25.13281 11.77137  1.43572   1.000 45.60485  ? 138 ILE B O   1 
ATOM   3274 C  CB  . ILE B 1 139 ? -24.27710 14.38424  3.08687   1.000 57.76513  ? 138 ILE B CB  1 
ATOM   3275 C  CG1 . ILE B 1 139 ? -23.42844 13.19188  3.52424   1.000 61.12420  ? 138 ILE B CG1 1 
ATOM   3276 C  CG2 . ILE B 1 139 ? -24.61706 15.23558  4.29549   1.000 54.13255  ? 138 ILE B CG2 1 
ATOM   3277 C  CD1 . ILE B 1 139 ? -22.17998 13.60172  4.27335   1.000 65.94923  ? 138 ILE B CD1 1 
ATOM   3278 N  N   . VAL B 1 140 ? -25.26933 13.51143  0.00835   1.000 55.72585  ? 139 VAL B N   1 
ATOM   3279 C  CA  . VAL B 1 140 ? -25.11462 12.68959  -1.18633  1.000 50.09213  ? 139 VAL B CA  1 
ATOM   3280 C  C   . VAL B 1 140 ? -23.63005 12.42881  -1.40456  1.000 55.26649  ? 139 VAL B C   1 
ATOM   3281 O  O   . VAL B 1 140 ? -22.84560 13.37020  -1.56743  1.000 53.13635  ? 139 VAL B O   1 
ATOM   3282 C  CB  . VAL B 1 140 ? -25.74657 13.36821  -2.41114  1.000 56.85819  ? 139 VAL B CB  1 
ATOM   3283 C  CG1 . VAL B 1 140 ? -25.29581 12.68165  -3.69614  1.000 47.58045  ? 139 VAL B CG1 1 
ATOM   3284 C  CG2 . VAL B 1 140 ? -27.26420 13.35015  -2.30739  1.000 52.67221  ? 139 VAL B CG2 1 
ATOM   3285 N  N   . ILE B 1 141 ? -23.23913 11.15450  -1.39832  1.000 50.68627  ? 140 ILE B N   1 
ATOM   3286 C  CA  . ILE B 1 141 ? -21.85600 10.75830  -1.61770  1.000 54.05322  ? 140 ILE B CA  1 
ATOM   3287 C  C   . ILE B 1 141 ? -21.73146 10.21818  -3.03246  1.000 57.68778  ? 140 ILE B C   1 
ATOM   3288 O  O   . ILE B 1 141 ? -22.53948 9.38058   -3.45885  1.000 58.74647  ? 140 ILE B O   1 
ATOM   3289 C  CB  . ILE B 1 141 ? -21.40203 9.70826   -0.59251  1.000 52.59035  ? 140 ILE B CB  1 
ATOM   3290 C  CG1 . ILE B 1 141 ? -21.71932 10.16118  0.83498   1.000 59.69653  ? 140 ILE B CG1 1 
ATOM   3291 C  CG2 . ILE B 1 141 ? -19.91006 9.43145   -0.75908  1.000 54.82218  ? 140 ILE B CG2 1 
ATOM   3292 C  CD1 . ILE B 1 141 ? -20.96800 11.39878  1.27387   1.000 50.73538  ? 140 ILE B CD1 1 
ATOM   3293 N  N   . GLU B 1 142 ? -20.71906 10.69231  -3.75616  1.000 61.38982  ? 141 GLU B N   1 
ATOM   3294 C  CA  . GLU B 1 142 ? -20.49534 10.32876  -5.15082  1.000 63.32976  ? 141 GLU B CA  1 
ATOM   3295 C  C   . GLU B 1 142 ? -19.19843 9.54004   -5.24085  1.000 65.02891  ? 141 GLU B C   1 
ATOM   3296 O  O   . GLU B 1 142 ? -18.11681 10.09323  -5.01833  1.000 61.93741  ? 141 GLU B O   1 
ATOM   3297 C  CB  . GLU B 1 142 ? -20.41877 11.56711  -6.04213  1.000 62.60258  ? 141 GLU B CB  1 
ATOM   3298 C  CG  . GLU B 1 142 ? -21.59315 12.51835  -5.94928  1.000 70.38470  ? 141 GLU B CG  1 
ATOM   3299 C  CD  . GLU B 1 142 ? -21.43322 13.72115  -6.86470  1.000 75.68272  ? 141 GLU B CD  1 
ATOM   3300 O  OE1 . GLU B 1 142 ? -20.92169 13.55680  -7.99496  1.000 69.75837  ? 141 GLU B OE1 1 
ATOM   3301 O  OE2 . GLU B 1 142 ? -21.81129 14.83593  -6.45092  1.000 66.42818  ? 141 GLU B OE2 1 
ATOM   3302 N  N   . GLN B 1 143 ? -19.30078 8.25418   -5.56061  1.000 67.65297  ? 142 GLN B N   1 
ATOM   3303 C  CA  . GLN B 1 143 ? -18.13732 7.44510   -5.91014  1.000 68.80653  ? 142 GLN B CA  1 
ATOM   3304 C  C   . GLN B 1 143 ? -18.32207 6.98019   -7.34837  1.000 70.90837  ? 142 GLN B C   1 
ATOM   3305 O  O   . GLN B 1 143 ? -19.24599 6.21126   -7.64244  1.000 62.37630  ? 142 GLN B O   1 
ATOM   3306 C  CB  . GLN B 1 143 ? -17.96560 6.26113   -4.95801  1.000 54.21663  ? 142 GLN B CB  1 
ATOM   3307 C  CG  . GLN B 1 143 ? -16.67873 5.47251   -5.18047  1.000 55.33642  ? 142 GLN B CG  1 
ATOM   3308 C  CD  . GLN B 1 143 ? -15.43747 6.34521   -5.11393  1.000 65.78281  ? 142 GLN B CD  1 
ATOM   3309 O  OE1 . GLN B 1 143 ? -15.32038 7.21268   -4.24930  1.000 67.19165  ? 142 GLN B OE1 1 
ATOM   3310 N  NE2 . GLN B 1 143 ? -14.50863 6.12669   -6.03915  1.000 65.98014  ? 142 GLN B NE2 1 
ATOM   3311 N  N   . GLY B 1 144 ? -17.45325 7.45562   -8.24091  1.000 75.59006  ? 143 GLY B N   1 
ATOM   3312 C  CA  . GLY B 1 144 ? -17.57045 7.13565   -9.64914  1.000 77.81628  ? 143 GLY B CA  1 
ATOM   3313 C  C   . GLY B 1 144 ? -18.86165 7.67553   -10.22602 1.000 78.03239  ? 143 GLY B C   1 
ATOM   3314 O  O   . GLY B 1 144 ? -19.01367 8.88602   -10.41399 1.000 88.50232  ? 143 GLY B O   1 
ATOM   3315 N  N   . ASN B 1 145 ? -19.80365 6.77675   -10.51338 1.000 77.88234  ? 144 ASN B N   1 
ATOM   3316 C  CA  . ASN B 1 145 ? -21.14755 7.15880   -10.91854 1.000 87.55752  ? 144 ASN B CA  1 
ATOM   3317 C  C   . ASN B 1 145 ? -22.17826 6.95405   -9.82116  1.000 79.21914  ? 144 ASN B C   1 
ATOM   3318 O  O   . ASN B 1 145 ? -23.23106 7.59787   -9.85341  1.000 76.31612  ? 144 ASN B O   1 
ATOM   3319 C  CB  . ASN B 1 145 ? -21.58201 6.36311   -12.15932 1.000 93.11032  ? 144 ASN B CB  1 
ATOM   3320 C  CG  . ASN B 1 145 ? -20.78941 6.73199   -13.39935 1.000 92.02902  ? 144 ASN B CG  1 
ATOM   3321 O  OD1 . ASN B 1 145 ? -19.58421 6.48292   -13.48189 1.000 92.65734  ? 144 ASN B OD1 1 
ATOM   3322 N  ND2 . ASN B 1 145 ? -21.46840 7.31299   -14.37983 1.000 95.33759  ? 144 ASN B ND2 1 
ATOM   3323 N  N   . TYR B 1 146 ? -21.89700 6.08772   -8.85441  1.000 74.16777  ? 145 TYR B N   1 
ATOM   3324 C  CA  . TYR B 1 146 ? -22.86338 5.78695   -7.80981  1.000 66.85477  ? 145 TYR B CA  1 
ATOM   3325 C  C   . TYR B 1 146 ? -22.99042 6.95503   -6.84111  1.000 63.55439  ? 145 TYR B C   1 
ATOM   3326 O  O   . TYR B 1 146 ? -21.99921 7.59094   -6.47011  1.000 66.71425  ? 145 TYR B O   1 
ATOM   3327 C  CB  . TYR B 1 146 ? -22.44183 4.52196   -7.06376  1.000 64.41953  ? 145 TYR B CB  1 
ATOM   3328 C  CG  . TYR B 1 146 ? -23.55380 3.78572   -6.35054  1.000 60.42532  ? 145 TYR B CG  1 
ATOM   3329 C  CD1 . TYR B 1 146 ? -24.63976 3.27514   -7.04966  1.000 58.29216  ? 145 TYR B CD1 1 
ATOM   3330 C  CD2 . TYR B 1 146 ? -23.49863 3.56976   -4.98061  1.000 63.10526  ? 145 TYR B CD2 1 
ATOM   3331 C  CE1 . TYR B 1 146 ? -25.65260 2.58582   -6.39744  1.000 68.07341  ? 145 TYR B CE1 1 
ATOM   3332 C  CE2 . TYR B 1 146 ? -24.50411 2.88121   -4.32206  1.000 61.77846  ? 145 TYR B CE2 1 
ATOM   3333 C  CZ  . TYR B 1 146 ? -25.57918 2.39450   -5.03516  1.000 68.72504  ? 145 TYR B CZ  1 
ATOM   3334 O  OH  . TYR B 1 146 ? -26.57504 1.70454   -4.38438  1.000 69.22951  ? 145 TYR B OH  1 
ATOM   3335 N  N   . LYS B 1 147 ? -24.22629 7.24354   -6.44250  1.000 61.35707  ? 146 LYS B N   1 
ATOM   3336 C  CA  . LYS B 1 147 ? -24.51768 8.25375   -5.43337  1.000 68.22901  ? 146 LYS B CA  1 
ATOM   3337 C  C   . LYS B 1 147 ? -25.36884 7.60484   -4.35654  1.000 65.50022  ? 146 LYS B C   1 
ATOM   3338 O  O   . LYS B 1 147 ? -26.41721 7.02554   -4.65872  1.000 62.64738  ? 146 LYS B O   1 
ATOM   3339 C  CB  . LYS B 1 147 ? -25.24566 9.46016   -6.03320  1.000 62.86319  ? 146 LYS B CB  1 
ATOM   3340 C  CG  . LYS B 1 147 ? -24.38190 10.37674  -6.87661  1.000 63.73796  ? 146 LYS B CG  1 
ATOM   3341 C  CD  . LYS B 1 147 ? -25.22815 11.43966  -7.55872  1.000 71.80313  ? 146 LYS B CD  1 
ATOM   3342 C  CE  . LYS B 1 147 ? -24.36802 12.48402  -8.24252  1.000 78.10140  ? 146 LYS B CE  1 
ATOM   3343 N  NZ  . LYS B 1 147 ? -23.24071 11.87952  -9.00137  1.000 81.97322  ? 146 LYS B NZ  1 
ATOM   3344 N  N   . PHE B 1 148 ? -24.92017 7.68844   -3.11048  1.000 59.13776  ? 147 PHE B N   1 
ATOM   3345 C  CA  . PHE B 1 148 ? -25.68578 7.13139   -2.00523  1.000 58.60413  ? 147 PHE B CA  1 
ATOM   3346 C  C   . PHE B 1 148 ? -25.90393 8.17631   -0.91836  1.000 54.18320  ? 147 PHE B C   1 
ATOM   3347 O  O   . PHE B 1 148 ? -25.06527 9.05234   -0.68924  1.000 50.99272  ? 147 PHE B O   1 
ATOM   3348 C  CB  . PHE B 1 148 ? -25.02944 5.85898   -1.42526  1.000 49.36374  ? 147 PHE B CB  1 
ATOM   3349 C  CG  . PHE B 1 148 ? -23.57262 6.00223   -1.07496  1.000 52.18491  ? 147 PHE B CG  1 
ATOM   3350 C  CD1 . PHE B 1 148 ? -22.59653 5.93427   -2.05746  1.000 51.44959  ? 147 PHE B CD1 1 
ATOM   3351 C  CD2 . PHE B 1 148 ? -23.17764 6.15376   0.24717   1.000 47.72897  ? 147 PHE B CD2 1 
ATOM   3352 C  CE1 . PHE B 1 148 ? -21.26101 6.04853   -1.73377  1.000 55.49202  ? 147 PHE B CE1 1 
ATOM   3353 C  CE2 . PHE B 1 148 ? -21.84541 6.26574   0.57655   1.000 57.76876  ? 147 PHE B CE2 1 
ATOM   3354 C  CZ  . PHE B 1 148 ? -20.88572 6.20891   -0.41271  1.000 62.67428  ? 147 PHE B CZ  1 
ATOM   3355 N  N   . ASN B 1 149 ? -27.05756 8.07537   -0.26124  1.000 51.97467  ? 148 ASN B N   1 
ATOM   3356 C  CA  . ASN B 1 149 ? -27.46734 9.02134   0.77365   1.000 51.27956  ? 148 ASN B CA  1 
ATOM   3357 C  C   . ASN B 1 149 ? -26.90147 8.54728   2.10770   1.000 54.59062  ? 148 ASN B C   1 
ATOM   3358 O  O   . ASN B 1 149 ? -27.38096 7.57095   2.69246   1.000 54.31104  ? 148 ASN B O   1 
ATOM   3359 C  CB  . ASN B 1 149 ? -28.98642 9.14391   0.81078   1.000 58.18634  ? 148 ASN B CB  1 
ATOM   3360 C  CG  . ASN B 1 149 ? -29.49138 10.33629  0.02663   1.000 60.00278  ? 148 ASN B CG  1 
ATOM   3361 O  OD1 . ASN B 1 149 ? -28.71045 11.04991  -0.59656  1.000 62.79502  ? 148 ASN B OD1 1 
ATOM   3362 N  ND2 . ASN B 1 149 ? -30.80311 10.55997  0.05416   1.000 65.28319  ? 148 ASN B ND2 1 
ATOM   3363 N  N   . LEU B 1 150 ? -25.84729 9.21556   2.56933   1.000 48.24632  ? 149 LEU B N   1 
ATOM   3364 C  CA  . LEU B 1 150 ? -25.23135 8.89258   3.84673   1.000 52.11884  ? 149 LEU B CA  1 
ATOM   3365 C  C   . LEU B 1 150 ? -25.90388 9.68174   4.96272   1.000 49.90673  ? 149 LEU B C   1 
ATOM   3366 O  O   . LEU B 1 150 ? -26.11580 10.89224  4.84050   1.000 53.73007  ? 149 LEU B O   1 
ATOM   3367 C  CB  . LEU B 1 150 ? -23.73409 9.19850   3.80402   1.000 54.03706  ? 149 LEU B CB  1 
ATOM   3368 C  CG  . LEU B 1 150 ? -22.90703 8.75016   5.00884   1.000 58.67874  ? 149 LEU B CG  1 
ATOM   3369 C  CD1 . LEU B 1 150 ? -22.90808 7.23574   5.11662   1.000 47.12905  ? 149 LEU B CD1 1 
ATOM   3370 C  CD2 . LEU B 1 150 ? -21.48523 9.27507   4.91432   1.000 51.70708  ? 149 LEU B CD2 1 
ATOM   3371 N  N   . SER B 1 151 ? -26.24871 8.98962   6.04444   1.000 48.33528  ? 150 SER B N   1 
ATOM   3372 C  CA  . SER B 1 151 ? -26.84990 9.59622   7.22374   1.000 52.58844  ? 150 SER B CA  1 
ATOM   3373 C  C   . SER B 1 151 ? -25.94923 9.33184   8.42044   1.000 56.02225  ? 150 SER B C   1 
ATOM   3374 O  O   . SER B 1 151 ? -25.53903 8.18751   8.65185   1.000 59.18635  ? 150 SER B O   1 
ATOM   3375 C  CB  . SER B 1 151 ? -28.25377 9.04361   7.48125   1.000 49.02192  ? 150 SER B CB  1 
ATOM   3376 O  OG  . SER B 1 151 ? -29.12421 9.36634   6.41133   1.000 63.02993  ? 150 SER B OG  1 
ATOM   3377 N  N   . ALA B 1 152 ? -25.63636 10.39050  9.16887   1.000 54.97249  ? 151 ALA B N   1 
ATOM   3378 C  CA  . ALA B 1 152 ? -24.73924 10.29048  10.31258  1.000 56.46327  ? 151 ALA B CA  1 
ATOM   3379 C  C   . ALA B 1 152 ? -25.06969 11.38801  11.30881  1.000 69.59672  ? 151 ALA B C   1 
ATOM   3380 O  O   . ALA B 1 152 ? -25.13155 12.56042  10.93318  1.000 72.83443  ? 151 ALA B O   1 
ATOM   3381 C  CB  . ALA B 1 152 ? -23.27637 10.41092  9.87925   1.000 47.43365  ? 151 ALA B CB  1 
ATOM   3382 N  N   . ALA B 1 153 ? -25.24253 11.01198  12.57307  1.000 66.21945  ? 152 ALA B N   1 
ATOM   3383 C  CA  . ALA B 1 153 ? -25.54832 11.94632  13.64989  1.000 63.93566  ? 152 ALA B CA  1 
ATOM   3384 C  C   . ALA B 1 153 ? -24.36965 12.02175  14.61183  1.000 64.25947  ? 152 ALA B C   1 
ATOM   3385 O  O   . ALA B 1 153 ? -23.87206 10.98743  15.07424  1.000 62.78020  ? 152 ALA B O   1 
ATOM   3386 C  CB  . ALA B 1 153 ? -26.81415 11.52637  14.40069  1.000 61.70352  ? 152 ALA B CB  1 
ATOM   3387 N  N   . PHE B 1 154 ? -23.92781 13.24282  14.91096  1.000 62.61371  ? 153 PHE B N   1 
ATOM   3388 C  CA  . PHE B 1 154 ? -22.74632 13.46694  15.73336  1.000 65.75351  ? 153 PHE B CA  1 
ATOM   3389 C  C   . PHE B 1 154 ? -23.19217 13.76169  17.16121  1.000 56.13195  ? 153 PHE B C   1 
ATOM   3390 O  O   . PHE B 1 154 ? -23.94598 14.71204  17.39465  1.000 63.45916  ? 153 PHE B O   1 
ATOM   3391 C  CB  . PHE B 1 154 ? -21.89775 14.61574  15.18281  1.000 53.54172  ? 153 PHE B CB  1 
ATOM   3392 C  CG  . PHE B 1 154 ? -21.37995 14.39546  13.77820  1.000 60.75037  ? 153 PHE B CG  1 
ATOM   3393 C  CD1 . PHE B 1 154 ? -21.54158 13.17974  13.12564  1.000 55.80712  ? 153 PHE B CD1 1 
ATOM   3394 C  CD2 . PHE B 1 154 ? -20.71644 15.41966  13.11705  1.000 63.68278  ? 153 PHE B CD2 1 
ATOM   3395 C  CE1 . PHE B 1 154 ? -21.06670 12.99492  11.84217  1.000 59.91726  ? 153 PHE B CE1 1 
ATOM   3396 C  CE2 . PHE B 1 154 ? -20.23475 15.24010  11.83592  1.000 56.23571  ? 153 PHE B CE2 1 
ATOM   3397 C  CZ  . PHE B 1 154 ? -20.40963 14.02640  11.19744  1.000 55.31000  ? 153 PHE B CZ  1 
ATOM   3398 N  N   . ASP B 1 155 ? -22.74038 12.93635  18.10905  1.000 60.56832  ? 154 ASP B N   1 
ATOM   3399 C  CA  . ASP B 1 155 ? -23.06640 13.17341  19.51282  1.000 58.86961  ? 154 ASP B CA  1 
ATOM   3400 C  C   . ASP B 1 155 ? -22.52889 14.51933  19.97696  1.000 55.17452  ? 154 ASP B C   1 
ATOM   3401 O  O   . ASP B 1 155 ? -23.23791 15.28530  20.63876  1.000 57.38405  ? 154 ASP B O   1 
ATOM   3402 C  CB  . ASP B 1 155 ? -22.52699 12.03855  20.38787  1.000 60.30894  ? 154 ASP B CB  1 
ATOM   3403 C  CG  . ASP B 1 155 ? -23.47437 10.85825  20.45598  1.000 62.88228  ? 154 ASP B CG  1 
ATOM   3404 O  OD1 . ASP B 1 155 ? -24.59791 10.95824  19.91716  1.000 63.94662  ? 154 ASP B OD1 1 
ATOM   3405 O  OD2 . ASP B 1 155 ? -23.09728 9.82449   21.04698  1.000 63.91398  ? 154 ASP B OD2 1 
ATOM   3406 N  N   . CYS B 1 156 ? -21.28342 14.83487  19.62513  1.000 53.71045  ? 155 CYS B N   1 
ATOM   3407 C  CA  . CYS B 1 156 ? -20.73859 16.14621  19.93899  1.000 55.67742  ? 155 CYS B CA  1 
ATOM   3408 C  C   . CYS B 1 156 ? -19.74556 16.56369  18.86863  1.000 48.36784  ? 155 CYS B C   1 
ATOM   3409 O  O   . CYS B 1 156 ? -19.03425 15.73237  18.29992  1.000 52.44599  ? 155 CYS B O   1 
ATOM   3410 C  CB  . CYS B 1 156 ? -20.04536 16.16754  21.30328  1.000 56.85159  ? 155 CYS B CB  1 
ATOM   3411 S  SG  . CYS B 1 156 ? -19.17963 17.72288  21.64534  1.000 58.60993  ? 155 CYS B SG  1 
ATOM   3412 N  N   . ILE B 1 157 ? -19.69638 17.86691  18.61070  1.000 45.01683  ? 156 ILE B N   1 
ATOM   3413 C  CA  . ILE B 1 157 ? -18.69531 18.46652  17.74108  1.000 57.65522  ? 156 ILE B CA  1 
ATOM   3414 C  C   . ILE B 1 157 ? -18.08523 19.64209  18.48596  1.000 59.90890  ? 156 ILE B C   1 
ATOM   3415 O  O   . ILE B 1 157 ? -18.81504 20.53127  18.94280  1.000 59.08614  ? 156 ILE B O   1 
ATOM   3416 C  CB  . ILE B 1 157 ? -19.29182 18.94828  16.40376  1.000 50.54530  ? 156 ILE B CB  1 
ATOM   3417 C  CG1 . ILE B 1 157 ? -20.48962 18.09418  15.97071  1.000 52.87820  ? 156 ILE B CG1 1 
ATOM   3418 C  CG2 . ILE B 1 157 ? -18.22165 18.94926  15.33501  1.000 55.76578  ? 156 ILE B CG2 1 
ATOM   3419 C  CD1 . ILE B 1 157 ? -21.26797 18.70725  14.82473  1.000 65.76834  ? 156 ILE B CD1 1 
ATOM   3420 N  N   . PHE B 1 158 ? -16.75569 19.66123  18.59380  1.000 58.50355  ? 157 PHE B N   1 
ATOM   3421 C  CA  . PHE B 1 158 ? -16.07512 20.81588  19.16885  1.000 57.27895  ? 157 PHE B CA  1 
ATOM   3422 C  C   . PHE B 1 158 ? -14.86382 21.15881  18.30936  1.000 65.19680  ? 157 PHE B C   1 
ATOM   3423 O  O   . PHE B 1 158 ? -14.50648 20.42919  17.38196  1.000 64.59931  ? 157 PHE B O   1 
ATOM   3424 C  CB  . PHE B 1 158 ? -15.70366 20.59642  20.65413  1.000 56.07136  ? 157 PHE B CB  1 
ATOM   3425 C  CG  . PHE B 1 158 ? -14.58017 19.61394  20.89656  1.000 59.95617  ? 157 PHE B CG  1 
ATOM   3426 C  CD1 . PHE B 1 158 ? -13.25062 20.00528  20.79815  1.000 60.84712  ? 157 PHE B CD1 1 
ATOM   3427 C  CD2 . PHE B 1 158 ? -14.85843 18.31495  21.29377  1.000 56.91602  ? 157 PHE B CD2 1 
ATOM   3428 C  CE1 . PHE B 1 158 ? -12.22572 19.10612  21.04359  1.000 64.97300  ? 157 PHE B CE1 1 
ATOM   3429 C  CE2 . PHE B 1 158 ? -13.83869 17.41357  21.54296  1.000 55.27137  ? 157 PHE B CE2 1 
ATOM   3430 C  CZ  . PHE B 1 158 ? -12.52203 17.80955  21.41935  1.000 58.98368  ? 157 PHE B CZ  1 
ATOM   3431 N  N   . ARG B 1 159 ? -14.27039 22.32070  18.57619  1.000 63.23767  ? 158 ARG B N   1 
ATOM   3432 C  CA  . ARG B 1 159 ? -13.11876 22.79909  17.82228  1.000 67.22306  ? 158 ARG B CA  1 
ATOM   3433 C  C   . ARG B 1 159 ? -11.93283 22.95858  18.76341  1.000 68.39128  ? 158 ARG B C   1 
ATOM   3434 O  O   . ARG B 1 159 ? -12.04106 23.62138  19.79880  1.000 64.30074  ? 158 ARG B O   1 
ATOM   3435 C  CB  . ARG B 1 159 ? -13.43457 24.11772  17.10682  1.000 64.03578  ? 158 ARG B CB  1 
ATOM   3436 C  CG  . ARG B 1 159 ? -12.26619 24.69686  16.32719  1.000 68.00506  ? 158 ARG B CG  1 
ATOM   3437 C  CD  . ARG B 1 159 ? -12.71535 25.73832  15.30432  1.000 74.44478  ? 158 ARG B CD  1 
ATOM   3438 N  NE  . ARG B 1 159 ? -13.75171 26.62401  15.82131  1.000 69.40267  ? 158 ARG B NE  1 
ATOM   3439 C  CZ  . ARG B 1 159 ? -14.92373 26.82581  15.23289  1.000 71.90605  ? 158 ARG B CZ  1 
ATOM   3440 N  NH1 . ARG B 1 159 ? -15.22808 26.25302  14.07909  1.000 61.16887  ? 158 ARG B NH1 1 
ATOM   3441 N  NH2 . ARG B 1 159 ? -15.80927 27.63181  15.80958  1.000 75.38980  ? 158 ARG B NH2 1 
ATOM   3442 N  N   . GLU B 1 160 ? -10.80351 22.35795  18.39703  1.000 74.41579  ? 159 GLU B N   1 
ATOM   3443 C  CA  . GLU B 1 160 ? -9.62022  22.34423  19.24340  1.000 73.71874  ? 159 GLU B CA  1 
ATOM   3444 C  C   . GLU B 1 160 ? -8.91885  23.70127  19.21587  1.000 77.82679  ? 159 GLU B C   1 
ATOM   3445 O  O   . GLU B 1 160 ? -9.39198  24.67180  18.61573  1.000 83.80180  ? 159 GLU B O   1 
ATOM   3446 C  CB  . GLU B 1 160 ? -8.66218  21.23945  18.80205  1.000 75.81023  ? 159 GLU B CB  1 
ATOM   3447 C  CG  . GLU B 1 160 ? -9.20640  19.83394  18.96934  1.000 67.58381  ? 159 GLU B CG  1 
ATOM   3448 C  CD  . GLU B 1 160 ? -8.22078  18.77693  18.52044  1.000 74.60981  ? 159 GLU B CD  1 
ATOM   3449 O  OE1 . GLU B 1 160 ? -7.07874  19.14655  18.17198  1.000 71.78809  ? 159 GLU B OE1 1 
ATOM   3450 O  OE2 . GLU B 1 160 ? -8.58528  17.58138  18.51452  1.000 78.25234  ? 159 GLU B OE2 1 
ATOM   3451 N  N   . ALA B 1 161 ? -7.76622  23.76374  19.88952  1.000 81.76536  ? 160 ALA B N   1 
ATOM   3452 C  CA  . ALA B 1 161 ? -6.98307  24.99366  19.92972  1.000 81.16935  ? 160 ALA B CA  1 
ATOM   3453 C  C   . ALA B 1 161 ? -6.36680  25.31462  18.57574  1.000 84.88069  ? 160 ALA B C   1 
ATOM   3454 O  O   . ALA B 1 161 ? -6.24337  26.49047  18.21479  1.000 98.10535  ? 160 ALA B O   1 
ATOM   3455 C  CB  . ALA B 1 161 ? -5.89216  24.88280  20.99365  1.000 86.78528  ? 160 ALA B CB  1 
ATOM   3456 N  N   . ASP B 1 162 ? -5.97308  24.29291  17.81741  1.000 86.65547  ? 161 ASP B N   1 
ATOM   3457 C  CA  . ASP B 1 162 ? -5.43400  24.48038  16.47962  1.000 82.92722  ? 161 ASP B CA  1 
ATOM   3458 C  C   . ASP B 1 162 ? -6.52138  24.51507  15.41437  1.000 81.52153  ? 161 ASP B C   1 
ATOM   3459 O  O   . ASP B 1 162 ? -6.23114  24.26358  14.23897  1.000 84.45711  ? 161 ASP B O   1 
ATOM   3460 C  CB  . ASP B 1 162 ? -4.41040  23.38549  16.16338  1.000 88.24823  ? 161 ASP B CB  1 
ATOM   3461 C  CG  . ASP B 1 162 ? -4.91230  21.99720  16.50821  1.000 87.20015  ? 161 ASP B CG  1 
ATOM   3462 O  OD1 . ASP B 1 162 ? -6.05851  21.88716  16.98920  1.000 93.37225  ? 161 ASP B OD1 1 
ATOM   3463 O  OD2 . ASP B 1 162 ? -4.16222  21.01764  16.30371  1.000 86.19871  ? 161 ASP B OD2 1 
ATOM   3464 N  N   . ASP B 1 163 ? -7.76103  24.82099  15.80313  1.000 79.70107  ? 162 ASP B N   1 
ATOM   3465 C  CA  . ASP B 1 163 ? -8.88663  24.91053  14.87279  1.000 90.89503  ? 162 ASP B CA  1 
ATOM   3466 C  C   . ASP B 1 163 ? -9.08976  23.60231  14.10884  1.000 78.69193  ? 162 ASP B C   1 
ATOM   3467 O  O   . ASP B 1 163 ? -9.40010  23.60020  12.91650  1.000 81.50182  ? 162 ASP B O   1 
ATOM   3468 C  CB  . ASP B 1 163 ? -8.71108  26.08912  13.90968  1.000 85.56860  ? 162 ASP B CB  1 
ATOM   3469 C  CG  . ASP B 1 163 ? -8.82168  27.43279  14.60686  1.000 90.55911  ? 162 ASP B CG  1 
ATOM   3470 O  OD1 . ASP B 1 163 ? -8.00903  27.70951  15.51646  1.000 97.13485  ? 162 ASP B OD1 1 
ATOM   3471 O  OD2 . ASP B 1 163 ? -9.72288  28.21834  14.24185  1.000 99.55614  ? 162 ASP B OD2 1 
ATOM   3472 N  N   . THR B 1 164 ? -8.90747  22.48048  14.80117  1.000 78.17051  ? 163 THR B N   1 
ATOM   3473 C  CA  . THR B 1 164 ? -9.15189  21.15697  14.24362  1.000 74.75462  ? 163 THR B CA  1 
ATOM   3474 C  C   . THR B 1 164 ? -10.53608 20.69662  14.68647  1.000 70.54802  ? 163 THR B C   1 
ATOM   3475 O  O   . THR B 1 164 ? -10.81050 20.61004  15.88824  1.000 69.34163  ? 163 THR B O   1 
ATOM   3476 C  CB  . THR B 1 164 ? -8.08037  20.16471  14.69893  1.000 77.60172  ? 163 THR B CB  1 
ATOM   3477 O  OG1 . THR B 1 164 ? -6.79549  20.59003  14.23091  1.000 82.97067  ? 163 THR B OG1 1 
ATOM   3478 C  CG2 . THR B 1 164 ? -8.37122  18.76177  14.16460  1.000 75.42509  ? 163 THR B CG2 1 
ATOM   3479 N  N   . ILE B 1 165 ? -11.40919 20.41861  13.72098  1.000 68.54751  ? 164 ILE B N   1 
ATOM   3480 C  CA  . ILE B 1 165 ? -12.75837 19.96568  14.04486  1.000 66.59355  ? 164 ILE B CA  1 
ATOM   3481 C  C   . ILE B 1 165 ? -12.67465 18.56323  14.63448  1.000 66.06261  ? 164 ILE B C   1 
ATOM   3482 O  O   . ILE B 1 165 ? -12.11059 17.64888  14.02076  1.000 63.33700  ? 164 ILE B O   1 
ATOM   3483 C  CB  . ILE B 1 165 ? -13.66487 20.00143  12.80749  1.000 64.61939  ? 164 ILE B CB  1 
ATOM   3484 C  CG1 . ILE B 1 165 ? -13.58692 21.37062  12.12337  1.000 58.81271  ? 164 ILE B CG1 1 
ATOM   3485 C  CG2 . ILE B 1 165 ? -15.10536 19.68534  13.19413  1.000 61.77164  ? 164 ILE B CG2 1 
ATOM   3486 C  CD1 . ILE B 1 165 ? -14.10050 22.52272  12.97225  1.000 64.92271  ? 164 ILE B CD1 1 
ATOM   3487 N  N   . HIS B 1 166 ? -13.22005 18.39020  15.83806  1.000 62.34567  ? 165 HIS B N   1 
ATOM   3488 C  CA  . HIS B 1 166 ? -13.17309 17.12936  16.56335  1.000 59.55134  ? 165 HIS B CA  1 
ATOM   3489 C  C   . HIS B 1 166 ? -14.59431 16.61107  16.72726  1.000 58.68167  ? 165 HIS B C   1 
ATOM   3490 O  O   . HIS B 1 166 ? -15.44195 17.28539  17.33086  1.000 62.73396  ? 165 HIS B O   1 
ATOM   3491 C  CB  . HIS B 1 166 ? -12.49343 17.31540  17.92230  1.000 61.20236  ? 165 HIS B CB  1 
ATOM   3492 C  CG  . HIS B 1 166 ? -12.14730 16.03248  18.61568  1.000 57.40604  ? 165 HIS B CG  1 
ATOM   3493 N  ND1 . HIS B 1 166 ? -10.86816 15.73948  19.03912  1.000 55.66835  ? 165 HIS B ND1 1 
ATOM   3494 C  CD2 . HIS B 1 166 ? -12.91356 14.97766  18.98210  1.000 60.49701  ? 165 HIS B CD2 1 
ATOM   3495 C  CE1 . HIS B 1 166 ? -10.85758 14.55494  19.62383  1.000 62.15481  ? 165 HIS B CE1 1 
ATOM   3496 N  NE2 . HIS B 1 166 ? -12.08665 14.07163  19.60311  1.000 61.24098  ? 165 HIS B NE2 1 
ATOM   3497 N  N   . ILE B 1 167 ? -14.85202 15.43176  16.16327  1.000 50.76708  ? 166 ILE B N   1 
ATOM   3498 C  CA  . ILE B 1 167 ? -16.10832 14.71820  16.34687  1.000 54.18551  ? 166 ILE B CA  1 
ATOM   3499 C  C   . ILE B 1 167 ? -15.93742 13.78101  17.53241  1.000 54.38076  ? 166 ILE B C   1 
ATOM   3500 O  O   . ILE B 1 167 ? -14.98425 12.99378  17.58103  1.000 53.55655  ? 166 ILE B O   1 
ATOM   3501 C  CB  . ILE B 1 167 ? -16.49057 13.93235  15.08000  1.000 49.62410  ? 166 ILE B CB  1 
ATOM   3502 C  CG1 . ILE B 1 167 ? -16.08806 14.69135  13.80822  1.000 55.40569  ? 166 ILE B CG1 1 
ATOM   3503 C  CG2 . ILE B 1 167 ? -17.98367 13.60437  15.08237  1.000 43.18211  ? 166 ILE B CG2 1 
ATOM   3504 C  CD1 . ILE B 1 167 ? -16.96254 15.88222  13.47712  1.000 56.96059  ? 166 ILE B CD1 1 
ATOM   3505 N  N   . LEU B 1 168 ? -16.84214 13.87467  18.49882  1.000 51.96983  ? 167 LEU B N   1 
ATOM   3506 C  CA  . LEU B 1 168 ? -16.78457 13.06807  19.70900  1.000 56.60318  ? 167 LEU B CA  1 
ATOM   3507 C  C   . LEU B 1 168 ? -18.05864 12.24181  19.78670  1.000 57.60458  ? 167 LEU B C   1 
ATOM   3508 O  O   . LEU B 1 168 ? -19.15730 12.79645  19.91660  1.000 56.73264  ? 167 LEU B O   1 
ATOM   3509 C  CB  . LEU B 1 168 ? -16.62037 13.95571  20.94001  1.000 52.64926  ? 167 LEU B CB  1 
ATOM   3510 C  CG  . LEU B 1 168 ? -16.53044 13.26595  22.30426  1.000 57.47386  ? 167 LEU B CG  1 
ATOM   3511 C  CD1 . LEU B 1 168 ? -15.37516 12.27683  22.36030  1.000 54.31261  ? 167 LEU B CD1 1 
ATOM   3512 C  CD2 . LEU B 1 168 ? -16.39720 14.29847  23.40695  1.000 61.60143  ? 167 LEU B CD2 1 
ATOM   3513 N  N   . ASP B 1 169 ? -17.91185 10.92490  19.68826  1.000 45.09498  ? 168 ASP B N   1 
ATOM   3514 C  CA  . ASP B 1 169 ? -19.01442 10.00524  19.92013  1.000 56.34862  ? 168 ASP B CA  1 
ATOM   3515 C  C   . ASP B 1 169 ? -18.96685 9.55505   21.37363  1.000 58.04915  ? 168 ASP B C   1 
ATOM   3516 O  O   . ASP B 1 169 ? -17.94362 9.04369   21.83829  1.000 55.93143  ? 168 ASP B O   1 
ATOM   3517 C  CB  . ASP B 1 169 ? -18.94351 8.80637   18.97705  1.000 55.18719  ? 168 ASP B CB  1 
ATOM   3518 C  CG  . ASP B 1 169 ? -20.09219 7.85384   19.17773  1.000 55.08564  ? 168 ASP B CG  1 
ATOM   3519 O  OD1 . ASP B 1 169 ? -21.25101 8.27968   19.00043  1.000 61.76537  ? 168 ASP B OD1 1 
ATOM   3520 O  OD2 . ASP B 1 169 ? -19.84353 6.68314   19.52751  1.000 62.64905  ? 168 ASP B OD2 1 
ATOM   3521 N  N   . LEU B 1 170 ? -20.06321 9.75666   22.08986  1.000 58.69150  ? 169 LEU B N   1 
ATOM   3522 C  CA  . LEU B 1 170 ? -20.13772 9.43902   23.50687  1.000 56.82156  ? 169 LEU B CA  1 
ATOM   3523 C  C   . LEU B 1 170 ? -20.84655 8.10428   23.68292  1.000 62.96984  ? 169 LEU B C   1 
ATOM   3524 O  O   . LEU B 1 170 ? -21.94976 7.90946   23.16250  1.000 65.09001  ? 169 LEU B O   1 
ATOM   3525 C  CB  . LEU B 1 170 ? -20.86069 10.55485  24.26197  1.000 53.82255  ? 169 LEU B CB  1 
ATOM   3526 C  CG  . LEU B 1 170 ? -20.12631 11.88044  24.06426  1.000 56.66159  ? 169 LEU B CG  1 
ATOM   3527 C  CD1 . LEU B 1 170 ? -20.94798 13.05967  24.55237  1.000 57.49063  ? 169 LEU B CD1 1 
ATOM   3528 C  CD2 . LEU B 1 170 ? -18.78814 11.81245  24.77963  1.000 63.90124  ? 169 LEU B CD2 1 
ATOM   3529 N  N   . LYS B 1 171 ? -20.20945 7.18990   24.40811  1.000 66.46373  ? 170 LYS B N   1 
ATOM   3530 C  CA  . LYS B 1 171 ? -20.71240 5.83673   24.58176  1.000 63.21822  ? 170 LYS B CA  1 
ATOM   3531 C  C   . LYS B 1 171 ? -21.04392 5.57204   26.04404  1.000 67.72675  ? 170 LYS B C   1 
ATOM   3532 O  O   . LYS B 1 171 ? -20.72466 6.36002   26.93717  1.000 65.45143  ? 170 LYS B O   1 
ATOM   3533 C  CB  . LYS B 1 171 ? -19.69956 4.80281   24.07729  1.000 61.01850  ? 170 LYS B CB  1 
ATOM   3534 C  CG  . LYS B 1 171 ? -19.46845 4.86273   22.57685  1.000 63.83800  ? 170 LYS B CG  1 
ATOM   3535 C  CD  . LYS B 1 171 ? -19.43165 3.47243   21.96948  1.000 70.60132  ? 170 LYS B CD  1 
ATOM   3536 C  CE  . LYS B 1 171 ? -19.64600 3.53230   20.47099  1.000 70.60497  ? 170 LYS B CE  1 
ATOM   3537 N  NZ  . LYS B 1 171 ? -20.89719 4.25931   20.13247  1.000 71.33196  ? 170 LYS B NZ  1 
ATOM   3538 N  N   . THR B 1 172 ? -21.71149 4.44431   26.27609  1.000 63.26317  ? 171 THR B N   1 
ATOM   3539 C  CA  . THR B 1 172 ? -22.01711 3.97349   27.61926  1.000 66.95668  ? 171 THR B CA  1 
ATOM   3540 C  C   . THR B 1 172 ? -21.79820 2.46953   27.66748  1.000 69.51518  ? 171 THR B C   1 
ATOM   3541 O  O   . THR B 1 172 ? -21.56424 1.82182   26.64399  1.000 64.30182  ? 171 THR B O   1 
ATOM   3542 C  CB  . THR B 1 172 ? -23.45651 4.31045   28.04054  1.000 64.10378  ? 171 THR B CB  1 
ATOM   3543 O  OG1 . THR B 1 172 ? -24.37203 3.81914   27.05494  1.000 70.18544  ? 171 THR B OG1 1 
ATOM   3544 C  CG2 . THR B 1 172 ? -23.64641 5.80977   28.19303  1.000 61.93979  ? 171 THR B CG2 1 
ATOM   3545 N  N   . GLY B 1 173 ? -21.87116 1.92112   28.87697  1.000 75.58324  ? 172 GLY B N   1 
ATOM   3546 C  CA  . GLY B 1 173 ? -21.78997 0.49508   29.09423  1.000 66.63356  ? 172 GLY B CA  1 
ATOM   3547 C  C   . GLY B 1 173 ? -20.45028 -0.07917  28.67596  1.000 73.15594  ? 172 GLY B C   1 
ATOM   3548 O  O   . GLY B 1 173 ? -19.41505 0.59652   28.67752  1.000 76.96015  ? 172 GLY B O   1 
ATOM   3549 N  N   . GLN B 1 174 ? -20.48021 -1.35666  28.29199  1.000 77.56276  ? 173 GLN B N   1 
ATOM   3550 C  CA  . GLN B 1 174 ? -19.30982 -2.08275  27.82407  1.000 80.68874  ? 173 GLN B CA  1 
ATOM   3551 C  C   . GLN B 1 174 ? -19.07971 -1.89353  26.33027  1.000 83.25125  ? 173 GLN B C   1 
ATOM   3552 O  O   . GLN B 1 174 ? -18.35719 -2.68759  25.71457  1.000 85.07259  ? 173 GLN B O   1 
ATOM   3553 C  CB  . GLN B 1 174 ? -19.45308 -3.57501  28.14054  1.000 82.84960  ? 173 GLN B CB  1 
ATOM   3554 C  CG  . GLN B 1 174 ? -18.12955 -4.32732  28.26824  1.000 87.46319  ? 173 GLN B CG  1 
ATOM   3555 C  CD  . GLN B 1 174 ? -18.29993 -5.83197  28.33244  1.000 96.81325  ? 173 GLN B CD  1 
ATOM   3556 O  OE1 . GLN B 1 174 ? -17.57508 -6.57398  27.67196  1.000 100.59628 ? 173 GLN B OE1 1 
ATOM   3557 N  NE2 . GLN B 1 174 ? -19.25079 -6.29079  29.13764  1.000 96.53324  ? 173 GLN B NE2 1 
ATOM   3558 N  N   . SER B 1 175 ? -19.69233 -0.87338  25.73029  1.000 83.43356  ? 174 SER B N   1 
ATOM   3559 C  CA  . SER B 1 175 ? -19.60061 -0.69076  24.28839  1.000 85.35142  ? 174 SER B CA  1 
ATOM   3560 C  C   . SER B 1 175 ? -18.15371 -0.53000  23.84783  1.000 87.92774  ? 174 SER B C   1 
ATOM   3561 O  O   . SER B 1 175 ? -17.39599 0.26329   24.41619  1.000 90.52126  ? 174 SER B O   1 
ATOM   3562 C  CB  . SER B 1 175 ? -20.42057 0.52445   23.85905  1.000 80.78298  ? 174 SER B CB  1 
ATOM   3563 O  OG  . SER B 1 175 ? -21.79506 0.31451   24.11575  1.000 80.40989  ? 174 SER B OG  1 
ATOM   3564 N  N   . ASN B 1 176 ? -17.78024 -1.29833  22.83177  1.000 88.59350  ? 175 ASN B N   1 
ATOM   3565 C  CA  . ASN B 1 176 ? -16.48700 -1.16004  22.19335  1.000 87.11846  ? 175 ASN B CA  1 
ATOM   3566 C  C   . ASN B 1 176 ? -16.51902 0.02924   21.23559  1.000 80.11579  ? 175 ASN B C   1 
ATOM   3567 O  O   . ASN B 1 176 ? -17.57454 0.59693   20.94670  1.000 84.00557  ? 175 ASN B O   1 
ATOM   3568 C  CB  . ASN B 1 176 ? -16.12141 -2.45131  21.45986  1.000 89.70427  ? 175 ASN B CB  1 
ATOM   3569 C  CG  . ASN B 1 176 ? -14.62785 -2.66258  21.36174  1.000 93.37790  ? 175 ASN B CG  1 
ATOM   3570 O  OD1 . ASN B 1 176 ? -13.84584 -1.94920  21.99194  1.000 95.78414  ? 175 ASN B OD1 1 
ATOM   3571 N  ND2 . ASN B 1 176 ? -14.22149 -3.65310  20.57863  1.000 93.59946  ? 175 ASN B ND2 1 
ATOM   3572 N  N   . PHE B 1 177 ? -15.34757 0.41720   20.74280  1.000 75.93445  ? 176 PHE B N   1 
ATOM   3573 C  CA  . PHE B 1 177 ? -15.22725 1.54675   19.82125  1.000 71.01612  ? 176 PHE B CA  1 
ATOM   3574 C  C   . PHE B 1 177 ? -14.91383 1.00186   18.43255  1.000 72.46672  ? 176 PHE B C   1 
ATOM   3575 O  O   . PHE B 1 177 ? -13.77239 0.63137   18.14569  1.000 74.76278  ? 176 PHE B O   1 
ATOM   3576 C  CB  . PHE B 1 177 ? -14.14501 2.52228   20.26789  1.000 64.28651  ? 176 PHE B CB  1 
ATOM   3577 C  CG  . PHE B 1 177 ? -14.33420 3.06587   21.65429  1.000 73.47034  ? 176 PHE B CG  1 
ATOM   3578 C  CD1 . PHE B 1 177 ? -15.58473 3.08924   22.25134  1.000 77.68056  ? 176 PHE B CD1 1 
ATOM   3579 C  CD2 . PHE B 1 177 ? -13.25045 3.56722   22.35854  1.000 66.67785  ? 176 PHE B CD2 1 
ATOM   3580 C  CE1 . PHE B 1 177 ? -15.74608 3.59057   23.52966  1.000 69.23764  ? 176 PHE B CE1 1 
ATOM   3581 C  CE2 . PHE B 1 177 ? -13.40726 4.07164   23.63305  1.000 57.31882  ? 176 PHE B CE2 1 
ATOM   3582 C  CZ  . PHE B 1 177 ? -14.65290 4.08363   24.21823  1.000 60.30179  ? 176 PHE B CZ  1 
ATOM   3583 N  N   . ASP B 1 178 ? -15.92425 0.97858   17.56711  1.000 68.61138  ? 177 ASP B N   1 
ATOM   3584 C  CA  . ASP B 1 178 ? -15.76278 0.51342   16.19312  1.000 59.63604  ? 177 ASP B CA  1 
ATOM   3585 C  C   . ASP B 1 178 ? -15.25391 1.67139   15.34046  1.000 57.02670  ? 177 ASP B C   1 
ATOM   3586 O  O   . ASP B 1 178 ? -15.97819 2.64474   15.10483  1.000 57.72131  ? 177 ASP B O   1 
ATOM   3587 C  CB  . ASP B 1 178 ? -17.08362 -0.03634  15.66040  1.000 54.65770  ? 177 ASP B CB  1 
ATOM   3588 C  CG  . ASP B 1 178 ? -16.92425 -0.76032  14.33881  1.000 57.30784  ? 177 ASP B CG  1 
ATOM   3589 O  OD1 . ASP B 1 178 ? -15.78901 -0.83409  13.82045  1.000 57.64070  ? 177 ASP B OD1 1 
ATOM   3590 O  OD2 . ASP B 1 178 ? -17.93742 -1.26492  13.81192  1.000 58.32305  ? 177 ASP B OD2 1 
ATOM   3591 N  N   . ARG B 1 179 ? -14.00802 1.56428   14.86884  1.000 55.62325  ? 178 ARG B N   1 
ATOM   3592 C  CA  . ARG B 1 179 ? -13.39513 2.64030   14.09623  1.000 63.81647  ? 178 ARG B CA  1 
ATOM   3593 C  C   . ARG B 1 179 ? -14.12406 2.91388   12.78770  1.000 60.50283  ? 178 ARG B C   1 
ATOM   3594 O  O   . ARG B 1 179 ? -13.90425 3.97073   12.18430  1.000 60.60804  ? 178 ARG B O   1 
ATOM   3595 C  CB  . ARG B 1 179 ? -11.92455 2.32066   13.81249  1.000 66.72608  ? 178 ARG B CB  1 
ATOM   3596 C  CG  . ARG B 1 179 ? -10.97591 2.67752   14.95193  1.000 72.11427  ? 178 ARG B CG  1 
ATOM   3597 C  CD  . ARG B 1 179 ? -11.02184 1.64890   16.06881  1.000 78.84875  ? 178 ARG B CD  1 
ATOM   3598 N  NE  . ARG B 1 179 ? -9.98326  1.86397   17.07017  1.000 82.96188  ? 178 ARG B NE  1 
ATOM   3599 C  CZ  . ARG B 1 179 ? -10.21905 2.19398   18.33370  1.000 86.21899  ? 178 ARG B CZ  1 
ATOM   3600 N  NH1 . ARG B 1 179 ? -11.44973 2.36835   18.78590  1.000 80.06685  ? 178 ARG B NH1 1 
ATOM   3601 N  NH2 . ARG B 1 179 ? -9.19550  2.33680   19.17013  1.000 91.52202  ? 178 ARG B NH2 1 
ATOM   3602 N  N   . ARG B 1 180 ? -14.98727 1.99579   12.34434  1.000 52.98665  ? 179 ARG B N   1 
ATOM   3603 C  CA  . ARG B 1 180 ? -15.79842 2.23685   11.15653  1.000 62.14816  ? 179 ARG B CA  1 
ATOM   3604 C  C   . ARG B 1 180 ? -16.82984 3.33554   11.39996  1.000 56.17028  ? 179 ARG B C   1 
ATOM   3605 O  O   . ARG B 1 180 ? -17.17009 4.08523   10.47354  1.000 50.76548  ? 179 ARG B O   1 
ATOM   3606 C  CB  . ARG B 1 180 ? -16.47692 0.93310   10.72101  1.000 56.02398  ? 179 ARG B CB  1 
ATOM   3607 C  CG  . ARG B 1 180 ? -15.50809 -0.22699  10.48888  1.000 55.56858  ? 179 ARG B CG  1 
ATOM   3608 C  CD  . ARG B 1 180 ? -16.23347 -1.48631  10.04064  1.000 53.81453  ? 179 ARG B CD  1 
ATOM   3609 N  NE  . ARG B 1 180 ? -17.26070 -1.89032  10.99227  1.000 59.36756  ? 179 ARG B NE  1 
ATOM   3610 C  CZ  . ARG B 1 180 ? -17.93348 -3.03002  10.92760  1.000 57.79194  ? 179 ARG B CZ  1 
ATOM   3611 N  NH1 . ARG B 1 180 ? -17.69935 -3.91597  9.97431   1.000 62.01386  ? 179 ARG B NH1 1 
ATOM   3612 N  NH2 . ARG B 1 180 ? -18.86483 -3.28635  11.84152  1.000 51.03091  ? 179 ARG B NH2 1 
ATOM   3613 N  N   . GLN B 1 181 ? -17.33222 3.45263   12.63489  1.000 54.40005  ? 180 GLN B N   1 
ATOM   3614 C  CA  . GLN B 1 181 ? -18.23196 4.55565   12.96082  1.000 52.43400  ? 180 GLN B CA  1 
ATOM   3615 C  C   . GLN B 1 181 ? -17.50347 5.89034   12.86291  1.000 56.01096  ? 180 GLN B C   1 
ATOM   3616 O  O   . GLN B 1 181 ? -18.03831 6.86746   12.31666  1.000 58.29938  ? 180 GLN B O   1 
ATOM   3617 C  CB  . GLN B 1 181 ? -18.81655 4.35333   14.35898  1.000 56.63161  ? 180 GLN B CB  1 
ATOM   3618 C  CG  . GLN B 1 181 ? -20.02606 5.22314   14.70192  1.000 54.43488  ? 180 GLN B CG  1 
ATOM   3619 C  CD  . GLN B 1 181 ? -20.60726 4.89021   16.07020  1.000 52.33732  ? 180 GLN B CD  1 
ATOM   3620 O  OE1 . GLN B 1 181 ? -19.99208 4.17414   16.85556  1.000 57.31649  ? 180 GLN B OE1 1 
ATOM   3621 N  NE2 . GLN B 1 181 ? -21.79905 5.40369   16.35454  1.000 49.07969  ? 180 GLN B NE2 1 
ATOM   3622 N  N   . ALA B 1 182 ? -16.26793 5.93930   13.36806  1.000 56.10326  ? 181 ALA B N   1 
ATOM   3623 C  CA  . ALA B 1 182 ? -15.45694 7.14192   13.22886  1.000 56.32037  ? 181 ALA B CA  1 
ATOM   3624 C  C   . ALA B 1 182 ? -15.14443 7.42333   11.76583  1.000 56.72447  ? 181 ALA B C   1 
ATOM   3625 O  O   . ALA B 1 182 ? -15.06470 8.58553   11.35460  1.000 52.61186  ? 181 ALA B O   1 
ATOM   3626 C  CB  . ALA B 1 182 ? -14.17156 7.00397   14.04172  1.000 52.57287  ? 181 ALA B CB  1 
ATOM   3627 N  N   . HIS B 1 183 ? -14.95835 6.36932   10.96555  1.000 53.59016  ? 182 HIS B N   1 
ATOM   3628 C  CA  . HIS B 1 183 ? -14.74826 6.55550   9.53354   1.000 58.37823  ? 182 HIS B CA  1 
ATOM   3629 C  C   . HIS B 1 183 ? -15.96900 7.20017   8.87671   1.000 48.40572  ? 182 HIS B C   1 
ATOM   3630 O  O   . HIS B 1 183 ? -15.83625 8.13921   8.07892   1.000 49.34015  ? 182 HIS B O   1 
ATOM   3631 C  CB  . HIS B 1 183 ? -14.42426 5.20955   8.88281   1.000 60.15323  ? 182 HIS B CB  1 
ATOM   3632 C  CG  . HIS B 1 183 ? -13.10651 4.63035   9.30454   1.000 62.12809  ? 182 HIS B CG  1 
ATOM   3633 N  ND1 . HIS B 1 183 ? -12.16666 5.34852   10.01335  1.000 61.19578  ? 182 HIS B ND1 1 
ATOM   3634 C  CD2 . HIS B 1 183 ? -12.57068 3.40145   9.11196   1.000 63.55654  ? 182 HIS B CD2 1 
ATOM   3635 C  CE1 . HIS B 1 183 ? -11.10914 4.58880   10.23874  1.000 62.77098  ? 182 HIS B CE1 1 
ATOM   3636 N  NE2 . HIS B 1 183 ? -11.32892 3.40222   9.70189   1.000 68.91364  ? 182 HIS B NE2 1 
ATOM   3637 N  N   . VAL B 1 184 ? -17.16798 6.71725   9.21790   1.000 45.77621  ? 183 VAL B N   1 
ATOM   3638 C  CA  . VAL B 1 184 ? -18.40190 7.30832   8.69820   1.000 47.33012  ? 183 VAL B CA  1 
ATOM   3639 C  C   . VAL B 1 184 ? -18.47923 8.78211   9.07541   1.000 48.22066  ? 183 VAL B C   1 
ATOM   3640 O  O   . VAL B 1 184 ? -18.77279 9.64893   8.23698   1.000 50.57760  ? 183 VAL B O   1 
ATOM   3641 C  CB  . VAL B 1 184 ? -19.62880 6.53381   9.21823   1.000 53.51947  ? 183 VAL B CB  1 
ATOM   3642 C  CG1 . VAL B 1 184 ? -20.90420 7.33381   8.98416   1.000 47.69067  ? 183 VAL B CG1 1 
ATOM   3643 C  CG2 . VAL B 1 184 ? -19.72630 5.16604   8.55691   1.000 49.61385  ? 183 VAL B CG2 1 
ATOM   3644 N  N   . TYR B 1 185 ? -18.21827 9.08319   10.35234  1.000 53.09974  ? 184 TYR B N   1 
ATOM   3645 C  CA  . TYR B 1 185 ? -18.34077 10.45741  10.82838  1.000 49.41879  ? 184 TYR B CA  1 
ATOM   3646 C  C   . TYR B 1 185 ? -17.30665 11.37155  10.17857  1.000 52.18910  ? 184 TYR B C   1 
ATOM   3647 O  O   . TYR B 1 185 ? -17.61385 12.51774  9.84531   1.000 44.01279  ? 184 TYR B O   1 
ATOM   3648 C  CB  . TYR B 1 185 ? -18.23303 10.50277  12.35181  1.000 54.44479  ? 184 TYR B CB  1 
ATOM   3649 C  CG  . TYR B 1 185 ? -19.42503 9.88886   13.04875  1.000 58.22439  ? 184 TYR B CG  1 
ATOM   3650 C  CD1 . TYR B 1 185 ? -20.61574 9.67030   12.36215  1.000 55.88635  ? 184 TYR B CD1 1 
ATOM   3651 C  CD2 . TYR B 1 185 ? -19.36542 9.52910   14.38840  1.000 42.54014  ? 184 TYR B CD2 1 
ATOM   3652 C  CE1 . TYR B 1 185 ? -21.71128 9.10968   12.98838  1.000 55.47884  ? 184 TYR B CE1 1 
ATOM   3653 C  CE2 . TYR B 1 185 ? -20.45952 8.96688   15.02304  1.000 48.96233  ? 184 TYR B CE2 1 
ATOM   3654 C  CZ  . TYR B 1 185 ? -21.62861 8.76032   14.31869  1.000 49.57184  ? 184 TYR B CZ  1 
ATOM   3655 O  OH  . TYR B 1 185 ? -22.71870 8.20389   14.94318  1.000 55.35176  ? 184 TYR B OH  1 
ATOM   3656 N  N   . LEU B 1 186 ? -16.07632 10.88719  9.98729   1.000 54.38429  ? 185 LEU B N   1 
ATOM   3657 C  CA  . LEU B 1 186 ? -15.05062 11.70642  9.34401   1.000 48.86393  ? 185 LEU B CA  1 
ATOM   3658 C  C   . LEU B 1 186 ? -15.39866 11.98222  7.88587   1.000 58.34470  ? 185 LEU B C   1 
ATOM   3659 O  O   . LEU B 1 186 ? -15.24412 13.11671  7.40080   1.000 61.00615  ? 185 LEU B O   1 
ATOM   3660 C  CB  . LEU B 1 186 ? -13.68521 11.02242  9.45334   1.000 51.21379  ? 185 LEU B CB  1 
ATOM   3661 C  CG  . LEU B 1 186 ? -13.07639 10.93520  10.85475  1.000 56.62900  ? 185 LEU B CG  1 
ATOM   3662 C  CD1 . LEU B 1 186 ? -11.76401 10.15812  10.85416  1.000 55.71168  ? 185 LEU B CD1 1 
ATOM   3663 C  CD2 . LEU B 1 186 ? -12.88418 12.32671  11.43841  1.000 56.15149  ? 185 LEU B CD2 1 
ATOM   3664 N  N   . LEU B 1 187 ? -15.89672 10.96248  7.17634   1.000 51.32652  ? 186 LEU B N   1 
ATOM   3665 C  CA  . LEU B 1 187 ? -16.32068 11.17508  5.79753   1.000 61.14036  ? 186 LEU B CA  1 
ATOM   3666 C  C   . LEU B 1 187 ? -17.42064 12.22429  5.73073   1.000 52.70084  ? 186 LEU B C   1 
ATOM   3667 O  O   . LEU B 1 187 ? -17.35820 13.16116  4.92516   1.000 54.51473  ? 186 LEU B O   1 
ATOM   3668 C  CB  . LEU B 1 187 ? -16.80561 9.86435   5.18359   1.000 50.67102  ? 186 LEU B CB  1 
ATOM   3669 C  CG  . LEU B 1 187 ? -17.39165 10.01717  3.77651   1.000 52.85462  ? 186 LEU B CG  1 
ATOM   3670 C  CD1 . LEU B 1 187 ? -16.30007 10.47373  2.83215   1.000 52.21896  ? 186 LEU B CD1 1 
ATOM   3671 C  CD2 . LEU B 1 187 ? -18.03935 8.72652   3.28449   1.000 49.23911  ? 186 LEU B CD2 1 
ATOM   3672 N  N   . ALA B 1 188 ? -18.43635 12.08516  6.58855   1.000 52.20619  ? 187 ALA B N   1 
ATOM   3673 C  CA  . ALA B 1 188 ? -19.53865 13.04070  6.59158   1.000 46.52166  ? 187 ALA B CA  1 
ATOM   3674 C  C   . ALA B 1 188 ? -19.05792 14.43907  6.96327   1.000 57.85048  ? 187 ALA B C   1 
ATOM   3675 O  O   . ALA B 1 188 ? -19.50325 15.43312  6.37925   1.000 52.46302  ? 187 ALA B O   1 
ATOM   3676 C  CB  . ALA B 1 188 ? -20.63296 12.57309  7.54895   1.000 46.35912  ? 187 ALA B CB  1 
ATOM   3677 N  N   . ALA B 1 189 ? -18.14909 14.53167  7.93803   1.000 53.21547  ? 188 ALA B N   1 
ATOM   3678 C  CA  . ALA B 1 189 ? -17.61297 15.81468  8.37157   1.000 59.52738  ? 188 ALA B CA  1 
ATOM   3679 C  C   . ALA B 1 189 ? -16.84820 16.50989  7.25954   1.000 55.69470  ? 188 ALA B C   1 
ATOM   3680 O  O   . ALA B 1 189 ? -16.82724 17.74470  7.20279   1.000 61.69845  ? 188 ALA B O   1 
ATOM   3681 C  CB  . ALA B 1 189 ? -16.71006 15.60928  9.58551   1.000 53.30516  ? 188 ALA B CB  1 
ATOM   3682 N  N   . SER B 1 190 ? -16.21469 15.74006  6.36947   1.000 58.58898  ? 189 SER B N   1 
ATOM   3683 C  CA  . SER B 1 190 ? -15.49982 16.35453  5.25564   1.000 60.39950  ? 189 SER B CA  1 
ATOM   3684 C  C   . SER B 1 190 ? -16.41469 17.19668  4.36696   1.000 67.00481  ? 189 SER B C   1 
ATOM   3685 O  O   . SER B 1 190 ? -15.91132 17.99456  3.57017   1.000 59.70390  ? 189 SER B O   1 
ATOM   3686 C  CB  . SER B 1 190 ? -14.80596 15.28109  4.41331   1.000 53.88469  ? 189 SER B CB  1 
ATOM   3687 O  OG  . SER B 1 190 ? -15.73195 14.59393  3.59543   1.000 67.72319  ? 189 SER B OG  1 
ATOM   3688 N  N   . TYR B 1 191 ? -17.73884 17.06525  4.50059   1.000 63.49317  ? 190 TYR B N   1 
ATOM   3689 C  CA  . TYR B 1 191 ? -18.68844 17.81134  3.68447   1.000 62.24416  ? 190 TYR B CA  1 
ATOM   3690 C  C   . TYR B 1 191 ? -19.31223 19.00080  4.40861   1.000 65.62003  ? 190 TYR B C   1 
ATOM   3691 O  O   . TYR B 1 191 ? -19.91401 19.85328  3.74779   1.000 69.08238  ? 190 TYR B O   1 
ATOM   3692 C  CB  . TYR B 1 191 ? -19.80103 16.88103  3.18382   1.000 58.03899  ? 190 TYR B CB  1 
ATOM   3693 C  CG  . TYR B 1 191 ? -19.34578 15.84339  2.18112   1.000 60.95167  ? 190 TYR B CG  1 
ATOM   3694 C  CD1 . TYR B 1 191 ? -18.58859 14.75511  2.58236   1.000 61.15292  ? 190 TYR B CD1 1 
ATOM   3695 C  CD2 . TYR B 1 191 ? -19.69588 15.93894  0.83853   1.000 63.12468  ? 190 TYR B CD2 1 
ATOM   3696 C  CE1 . TYR B 1 191 ? -18.17161 13.80116  1.68071   1.000 51.88029  ? 190 TYR B CE1 1 
ATOM   3697 C  CE2 . TYR B 1 191 ? -19.28561 14.98491  -0.07561  1.000 56.96992  ? 190 TYR B CE2 1 
ATOM   3698 C  CZ  . TYR B 1 191 ? -18.52277 13.91787  0.35125   1.000 59.11694  ? 190 TYR B CZ  1 
ATOM   3699 O  OH  . TYR B 1 191 ? -18.10732 12.96287  -0.54729  1.000 51.45276  ? 190 TYR B OH  1 
ATOM   3700 N  N   . ARG B 1 192 ? -19.18291 19.09100  5.73515   1.000 64.32224  ? 191 ARG B N   1 
ATOM   3701 C  CA  . ARG B 1 192 ? -19.61758 20.27549  6.46752   1.000 63.45650  ? 191 ARG B CA  1 
ATOM   3702 C  C   . ARG B 1 192 ? -18.47095 21.21215  6.80659   1.000 63.22127  ? 191 ARG B C   1 
ATOM   3703 O  O   . ARG B 1 192 ? -18.69337 22.41598  6.95195   1.000 65.47243  ? 191 ARG B O   1 
ATOM   3704 C  CB  . ARG B 1 192 ? -20.34283 19.88467  7.76449   1.000 55.68990  ? 191 ARG B CB  1 
ATOM   3705 C  CG  . ARG B 1 192 ? -21.31420 20.95845  8.25889   1.000 71.82578  ? 191 ARG B CG  1 
ATOM   3706 C  CD  . ARG B 1 192 ? -21.31581 21.09237  9.77341   1.000 77.92600  ? 191 ARG B CD  1 
ATOM   3707 N  NE  . ARG B 1 192 ? -22.24376 20.18170  10.43152  1.000 79.57108  ? 191 ARG B NE  1 
ATOM   3708 C  CZ  . ARG B 1 192 ? -22.56538 20.25516  11.71595  1.000 79.59106  ? 191 ARG B CZ  1 
ATOM   3709 N  NH1 . ARG B 1 192 ? -22.04732 21.18217  12.50589  1.000 73.45138  ? 191 ARG B NH1 1 
ATOM   3710 N  NH2 . ARG B 1 192 ? -23.43196 19.38158  12.22011  1.000 76.53456  ? 191 ARG B NH2 1 
ATOM   3711 N  N   . TYR B 1 193 ? -17.25175 20.68763  6.91624   1.000 58.62498  ? 192 TYR B N   1 
ATOM   3712 C  CA  . TYR B 1 193 ? -16.04155 21.49009  7.09076   1.000 58.42868  ? 192 TYR B CA  1 
ATOM   3713 C  C   . TYR B 1 193 ? -15.02277 21.05646  6.04756   1.000 57.84840  ? 192 TYR B C   1 
ATOM   3714 O  O   . TYR B 1 193 ? -14.00710 20.42452  6.36540   1.000 56.54530  ? 192 TYR B O   1 
ATOM   3715 C  CB  . TYR B 1 193 ? -15.48941 21.35076  8.50782   1.000 55.17513  ? 192 TYR B CB  1 
ATOM   3716 C  CG  . TYR B 1 193 ? -16.52820 21.65419  9.55037   1.000 66.56589  ? 192 TYR B CG  1 
ATOM   3717 C  CD1 . TYR B 1 193 ? -16.83393 22.96496  9.88782   1.000 63.11735  ? 192 TYR B CD1 1 
ATOM   3718 C  CD2 . TYR B 1 193 ? -17.22253 20.63194  10.18175  1.000 67.11776  ? 192 TYR B CD2 1 
ATOM   3719 C  CE1 . TYR B 1 193 ? -17.79772 23.25120  10.83832  1.000 65.98074  ? 192 TYR B CE1 1 
ATOM   3720 C  CE2 . TYR B 1 193 ? -18.18617 20.90620  11.13568  1.000 71.18303  ? 192 TYR B CE2 1 
ATOM   3721 C  CZ  . TYR B 1 193 ? -18.47098 22.21730  11.45805  1.000 70.18180  ? 192 TYR B CZ  1 
ATOM   3722 O  OH  . TYR B 1 193 ? -19.43130 22.49062  12.40251  1.000 71.57369  ? 192 TYR B OH  1 
ATOM   3723 N  N   . PRO B 1 194 ? -15.26113 21.39897  4.77851   1.000 61.16356  ? 193 PRO B N   1 
ATOM   3724 C  CA  . PRO B 1 194 ? -14.42270 20.87608  3.69073   1.000 59.77448  ? 193 PRO B CA  1 
ATOM   3725 C  C   . PRO B 1 194 ? -13.03398 21.48496  3.62989   1.000 66.67808  ? 193 PRO B C   1 
ATOM   3726 O  O   . PRO B 1 194 ? -12.25379 21.11452  2.74395   1.000 69.62301  ? 193 PRO B O   1 
ATOM   3727 C  CB  . PRO B 1 194 ? -15.23092 21.22712  2.42711   1.000 65.72748  ? 193 PRO B CB  1 
ATOM   3728 C  CG  . PRO B 1 194 ? -16.58314 21.71443  2.93066   1.000 62.14660  ? 193 PRO B CG  1 
ATOM   3729 C  CD  . PRO B 1 194 ? -16.32124 22.28353  4.27498   1.000 66.10522  ? 193 PRO B CD  1 
ATOM   3730 N  N   . GLN B 1 195 ? -12.70049 22.39962  4.53706   1.000 74.14832  ? 194 GLN B N   1 
ATOM   3731 C  CA  . GLN B 1 195 ? -11.41664 23.08024  4.52242   1.000 72.95936  ? 194 GLN B CA  1 
ATOM   3732 C  C   . GLN B 1 195 ? -10.59412 22.82162  5.77574   1.000 76.90324  ? 194 GLN B C   1 
ATOM   3733 O  O   . GLN B 1 195 ? -9.42674  23.22712  5.82802   1.000 83.12118  ? 194 GLN B O   1 
ATOM   3734 C  CB  . GLN B 1 195 ? -11.62272 24.59179  4.36267   1.000 73.45079  ? 194 GLN B CB  1 
ATOM   3735 C  CG  . GLN B 1 195 ? -12.80043 24.97615  3.47641   1.000 76.94730  ? 194 GLN B CG  1 
ATOM   3736 C  CD  . GLN B 1 195 ? -12.49671 24.82357  2.00330   1.000 72.66111  ? 194 GLN B CD  1 
ATOM   3737 O  OE1 . GLN B 1 195 ? -11.36091 24.54206  1.61468   1.000 75.73290  ? 194 GLN B OE1 1 
ATOM   3738 N  NE2 . GLN B 1 195 ? -13.51287 25.01617  1.17018   1.000 73.01328  ? 194 GLN B NE2 1 
ATOM   3739 N  N   . GLU B 1 196 ? -11.15744 22.15025  6.77512   1.000 75.75201  ? 195 GLU B N   1 
ATOM   3740 C  CA  . GLU B 1 196 ? -10.52833 21.97998  8.07363   1.000 76.86743  ? 195 GLU B CA  1 
ATOM   3741 C  C   . GLU B 1 196 ? -10.01023 20.55781  8.23588   1.000 74.00876  ? 195 GLU B C   1 
ATOM   3742 O  O   . GLU B 1 196 ? -10.56472 19.60692  7.67816   1.000 80.89837  ? 195 GLU B O   1 
ATOM   3743 C  CB  . GLU B 1 196 ? -11.51951 22.30089  9.19464   1.000 72.62831  ? 195 GLU B CB  1 
ATOM   3744 C  CG  . GLU B 1 196 ? -12.13505 23.67989  9.09337   1.000 78.42449  ? 195 GLU B CG  1 
ATOM   3745 C  CD  . GLU B 1 196 ? -11.15075 24.78081  9.43178   1.000 99.07041  ? 195 GLU B CD  1 
ATOM   3746 O  OE1 . GLU B 1 196 ? -10.55666 24.73315  10.52780  1.000 87.53556  ? 195 GLU B OE1 1 
ATOM   3747 O  OE2 . GLU B 1 196 ? -10.96948 25.69968  8.60432   1.000 101.00463 ? 195 GLU B OE2 1 
ATOM   3748 N  N   . LYS B 1 197 ? -8.92535  20.42428  8.99204   1.000 71.71671  ? 196 LYS B N   1 
ATOM   3749 C  CA  . LYS B 1 197 ? -8.48528  19.10396  9.41296   1.000 73.23476  ? 196 LYS B CA  1 
ATOM   3750 C  C   . LYS B 1 197 ? -9.44871  18.59254  10.47276  1.000 69.07947  ? 196 LYS B C   1 
ATOM   3751 O  O   . LYS B 1 197 ? -9.82401  19.32663  11.39084  1.000 71.44220  ? 196 LYS B O   1 
ATOM   3752 C  CB  . LYS B 1 197 ? -7.05555  19.14714  9.95292   1.000 73.85851  ? 196 LYS B CB  1 
ATOM   3753 C  CG  . LYS B 1 197 ? -6.32718  17.81643  9.82185   1.000 81.54403  ? 196 LYS B CG  1 
ATOM   3754 C  CD  . LYS B 1 197 ? -5.04394  17.77594  10.63593  1.000 87.58899  ? 196 LYS B CD  1 
ATOM   3755 C  CE  . LYS B 1 197 ? -5.33147  17.75123  12.12779  1.000 91.99923  ? 196 LYS B CE  1 
ATOM   3756 N  NZ  . LYS B 1 197 ? -4.09752  17.46710  12.91132  1.000 93.53447  ? 196 LYS B NZ  1 
ATOM   3757 N  N   . ILE B 1 198 ? -9.87940  17.34604  10.32690  1.000 71.56382  ? 197 ILE B N   1 
ATOM   3758 C  CA  . ILE B 1 198 ? -10.96886 16.79794  11.12286  1.000 67.28850  ? 197 ILE B CA  1 
ATOM   3759 C  C   . ILE B 1 198 ? -10.50280 15.50661  11.77721  1.000 66.60220  ? 197 ILE B C   1 
ATOM   3760 O  O   . ILE B 1 198 ? -9.86760  14.66627  11.13191  1.000 69.55412  ? 197 ILE B O   1 
ATOM   3761 C  CB  . ILE B 1 198 ? -12.22434 16.55840  10.25829  1.000 66.27756  ? 197 ILE B CB  1 
ATOM   3762 C  CG1 . ILE B 1 198 ? -12.60923 17.85268  9.52880   1.000 67.39361  ? 197 ILE B CG1 1 
ATOM   3763 C  CG2 . ILE B 1 198 ? -13.37937 16.05267  11.10748  1.000 62.85318  ? 197 ILE B CG2 1 
ATOM   3764 C  CD1 . ILE B 1 198 ? -13.68434 17.67157  8.48580   1.000 60.11770  ? 197 ILE B CD1 1 
ATOM   3765 N  N   . VAL B 1 199 ? -10.81006 15.35307  13.06459  1.000 62.76922  ? 198 VAL B N   1 
ATOM   3766 C  CA  . VAL B 1 199 ? -10.43306 14.17086  13.82514  1.000 62.51321  ? 198 VAL B CA  1 
ATOM   3767 C  C   . VAL B 1 199 ? -11.66497 13.65049  14.55525  1.000 64.77244  ? 198 VAL B C   1 
ATOM   3768 O  O   . VAL B 1 199 ? -12.65392 14.36333  14.73890  1.000 56.94871  ? 198 VAL B O   1 
ATOM   3769 C  CB  . VAL B 1 199 ? -9.28707  14.45868  14.82068  1.000 60.06864  ? 198 VAL B CB  1 
ATOM   3770 C  CG1 . VAL B 1 199 ? -7.99237  14.73846  14.07627  1.000 60.45531  ? 198 VAL B CG1 1 
ATOM   3771 C  CG2 . VAL B 1 199 ? -9.64479  15.63038  15.71809  1.000 59.99350  ? 198 VAL B CG2 1 
ATOM   3772 N  N   . ALA B 1 200 ? -11.59865 12.38377  14.96695  1.000 59.77764  ? 199 ALA B N   1 
ATOM   3773 C  CA  . ALA B 1 200 ? -12.71154 11.73595  15.64759  1.000 60.45718  ? 199 ALA B CA  1 
ATOM   3774 C  C   . ALA B 1 200 ? -12.19838 10.96088  16.85450  1.000 54.16765  ? 199 ALA B C   1 
ATOM   3775 O  O   . ALA B 1 200 ? -11.02546 10.58547  16.91970  1.000 53.16418  ? 199 ALA B O   1 
ATOM   3776 C  CB  . ALA B 1 200 ? -13.48608 10.80176  14.70296  1.000 57.19385  ? 199 ALA B CB  1 
ATOM   3777 N  N   . SER B 1 201 ? -13.08599 10.73954  17.82043  1.000 47.26475  ? 200 SER B N   1 
ATOM   3778 C  CA  . SER B 1 201 ? -12.72610 9.99347   19.01813  1.000 57.54783  ? 200 SER B CA  1 
ATOM   3779 C  C   . SER B 1 201 ? -13.99298 9.55004   19.73106  1.000 57.87610  ? 200 SER B C   1 
ATOM   3780 O  O   . SER B 1 201 ? -15.08420 10.07527  19.49230  1.000 55.65702  ? 200 SER B O   1 
ATOM   3781 C  CB  . SER B 1 201 ? -11.85646 10.82431  19.96774  1.000 48.52730  ? 200 SER B CB  1 
ATOM   3782 O  OG  . SER B 1 201 ? -12.64317 11.79536  20.63288  1.000 49.17123  ? 200 SER B OG  1 
ATOM   3783 N  N   . PHE B 1 202 ? -13.82148 8.57612   20.61685  1.000 52.83120  ? 201 PHE B N   1 
ATOM   3784 C  CA  . PHE B 1 202 ? -14.87497 8.05800   21.47100  1.000 56.54066  ? 201 PHE B CA  1 
ATOM   3785 C  C   . PHE B 1 202 ? -14.59969 8.43346   22.92086  1.000 54.45798  ? 201 PHE B C   1 
ATOM   3786 O  O   . PHE B 1 202 ? -13.46807 8.74571   23.30435  1.000 57.15548  ? 201 PHE B O   1 
ATOM   3787 C  CB  . PHE B 1 202 ? -14.98402 6.53332   21.34834  1.000 56.44467  ? 201 PHE B CB  1 
ATOM   3788 C  CG  . PHE B 1 202 ? -15.36707 6.05433   19.97706  1.000 58.75750  ? 201 PHE B CG  1 
ATOM   3789 C  CD1 . PHE B 1 202 ? -14.39924 5.80536   19.02082  1.000 52.63236  ? 201 PHE B CD1 1 
ATOM   3790 C  CD2 . PHE B 1 202 ? -16.69571 5.84255   19.64892  1.000 53.09484  ? 201 PHE B CD2 1 
ATOM   3791 C  CE1 . PHE B 1 202 ? -14.75015 5.35858   17.76093  1.000 57.02224  ? 201 PHE B CE1 1 
ATOM   3792 C  CE2 . PHE B 1 202 ? -17.05028 5.39739   18.39224  1.000 45.57195  ? 201 PHE B CE2 1 
ATOM   3793 C  CZ  . PHE B 1 202 ? -16.07669 5.15530   17.44701  1.000 58.74355  ? 201 PHE B CZ  1 
ATOM   3794 N  N   . TYR B 1 203 ? -15.66088 8.40330   23.72313  1.000 54.89423  ? 202 TYR B N   1 
ATOM   3795 C  CA  . TYR B 1 203 ? -15.55295 8.58688   25.16661  1.000 59.90925  ? 202 TYR B CA  1 
ATOM   3796 C  C   . TYR B 1 203 ? -16.74193 7.89536   25.80924  1.000 51.91720  ? 202 TYR B C   1 
ATOM   3797 O  O   . TYR B 1 203 ? -17.88718 8.27865   25.56132  1.000 55.59594  ? 202 TYR B O   1 
ATOM   3798 C  CB  . TYR B 1 203 ? -15.52151 10.06869  25.54701  1.000 57.00186  ? 202 TYR B CB  1 
ATOM   3799 C  CG  . TYR B 1 203 ? -15.31536 10.31911  27.02544  1.000 54.65076  ? 202 TYR B CG  1 
ATOM   3800 C  CD1 . TYR B 1 203 ? -14.05470 10.21443  27.59562  1.000 57.18639  ? 202 TYR B CD1 1 
ATOM   3801 C  CD2 . TYR B 1 203 ? -16.37788 10.66944  27.84660  1.000 54.05683  ? 202 TYR B CD2 1 
ATOM   3802 C  CE1 . TYR B 1 203 ? -13.85786 10.44600  28.94151  1.000 59.22985  ? 202 TYR B CE1 1 
ATOM   3803 C  CE2 . TYR B 1 203 ? -16.19011 10.90611  29.19488  1.000 53.38804  ? 202 TYR B CE2 1 
ATOM   3804 C  CZ  . TYR B 1 203 ? -14.92819 10.79224  29.73712  1.000 56.08078  ? 202 TYR B CZ  1 
ATOM   3805 O  OH  . TYR B 1 203 ? -14.73577 11.02476  31.07992  1.000 55.92603  ? 202 TYR B OH  1 
ATOM   3806 N  N   . ASN B 1 204 ? -16.47853 6.87273   26.61186  1.000 54.14824  ? 203 ASN B N   1 
ATOM   3807 C  CA  . ASN B 1 204 ? -17.53246 6.15749   27.31709  1.000 55.27883  ? 203 ASN B CA  1 
ATOM   3808 C  C   . ASN B 1 204 ? -17.77846 6.86808   28.64033  1.000 58.28430  ? 203 ASN B C   1 
ATOM   3809 O  O   . ASN B 1 204 ? -16.89155 6.92220   29.49768  1.000 51.67363  ? 203 ASN B O   1 
ATOM   3810 C  CB  . ASN B 1 204 ? -17.14112 4.69234   27.51620  1.000 54.93898  ? 203 ASN B CB  1 
ATOM   3811 C  CG  . ASN B 1 204 ? -18.23415 3.85815   28.18190  1.000 63.25073  ? 203 ASN B CG  1 
ATOM   3812 O  OD1 . ASN B 1 204 ? -18.78096 4.23011   29.22285  1.000 54.87842  ? 203 ASN B OD1 1 
ATOM   3813 N  ND2 . ASN B 1 204 ? -18.54530 2.71265   27.58114  1.000 64.81362  ? 203 ASN B ND2 1 
ATOM   3814 N  N   . LEU B 1 205 ? -18.97879 7.42406   28.79425  1.000 55.74337  ? 204 LEU B N   1 
ATOM   3815 C  CA  . LEU B 1 205 ? -19.27404 8.24741   29.95733  1.000 51.45307  ? 204 LEU B CA  1 
ATOM   3816 C  C   . LEU B 1 205 ? -19.32785 7.43859   31.24892  1.000 64.26385  ? 204 LEU B C   1 
ATOM   3817 O  O   . LEU B 1 205 ? -19.22780 8.02075   32.33506  1.000 64.13417  ? 204 LEU B O   1 
ATOM   3818 C  CB  . LEU B 1 205 ? -20.59085 8.98781   29.74194  1.000 49.29082  ? 204 LEU B CB  1 
ATOM   3819 C  CG  . LEU B 1 205 ? -20.62798 9.98815   28.58524  1.000 56.02289  ? 204 LEU B CG  1 
ATOM   3820 C  CD1 . LEU B 1 205 ? -22.05838 10.40488  28.29248  1.000 57.48460  ? 204 LEU B CD1 1 
ATOM   3821 C  CD2 . LEU B 1 205 ? -19.76593 11.21179  28.88407  1.000 53.43872  ? 204 LEU B CD2 1 
ATOM   3822 N  N   . GLU B 1 206 ? -19.46721 6.11550   31.15790  1.000 62.36492  ? 205 GLU B N   1 
ATOM   3823 C  CA  . GLU B 1 206 ? -19.54441 5.26059   32.33801  1.000 59.91240  ? 205 GLU B CA  1 
ATOM   3824 C  C   . GLU B 1 206 ? -18.15210 4.85527   32.81386  1.000 61.47646  ? 205 GLU B C   1 
ATOM   3825 O  O   . GLU B 1 206 ? -17.78969 5.08689   33.97134  1.000 65.63312  ? 205 GLU B O   1 
ATOM   3826 C  CB  . GLU B 1 206 ? -20.39635 4.02638   32.02549  1.000 71.33023  ? 205 GLU B CB  1 
ATOM   3827 C  CG  . GLU B 1 206 ? -21.00962 3.36354   33.24161  1.000 70.62410  ? 205 GLU B CG  1 
ATOM   3828 C  CD  . GLU B 1 206 ? -21.81105 2.13744   32.87437  1.000 78.67129  ? 205 GLU B CD  1 
ATOM   3829 O  OE1 . GLU B 1 206 ? -21.21676 1.18911   32.31767  1.000 82.22538  ? 205 GLU B OE1 1 
ATOM   3830 O  OE2 . GLU B 1 206 ? -23.03442 2.12746   33.12976  1.000 80.99687  ? 205 GLU B OE2 1 
ATOM   3831 N  N   . THR B 1 207 ? -17.36331 4.24821   31.92751  1.000 64.43662  ? 206 THR B N   1 
ATOM   3832 C  CA  . THR B 1 207 ? -16.00080 3.86776   32.27211  1.000 62.67551  ? 206 THR B CA  1 
ATOM   3833 C  C   . THR B 1 207 ? -15.04259 5.05082   32.26792  1.000 57.34628  ? 206 THR B C   1 
ATOM   3834 O  O   . THR B 1 207 ? -13.89944 4.89747   32.71267  1.000 55.15394  ? 206 THR B O   1 
ATOM   3835 C  CB  . THR B 1 207 ? -15.49358 2.79167   31.31071  1.000 60.20856  ? 206 THR B CB  1 
ATOM   3836 O  OG1 . THR B 1 207 ? -14.28148 2.22505   31.82403  1.000 70.53310  ? 206 THR B OG1 1 
ATOM   3837 C  CG2 . THR B 1 207 ? -15.22129 3.38968   29.95416  1.000 57.25394  ? 206 THR B CG2 1 
ATOM   3838 N  N   . GLN B 1 208 ? -15.47345 6.21035   31.76618  1.000 59.07715  ? 207 GLN B N   1 
ATOM   3839 C  CA  . GLN B 1 208 ? -14.64018 7.41100   31.69937  1.000 57.75220  ? 207 GLN B CA  1 
ATOM   3840 C  C   . GLN B 1 208 ? -13.36933 7.17966   30.88576  1.000 62.38108  ? 207 GLN B C   1 
ATOM   3841 O  O   . GLN B 1 208 ? -12.33210 7.79008   31.15175  1.000 63.15295  ? 207 GLN B O   1 
ATOM   3842 C  CB  . GLN B 1 208 ? -14.29537 7.93022   33.09877  1.000 65.00301  ? 207 GLN B CB  1 
ATOM   3843 C  CG  . GLN B 1 208 ? -15.47975 8.50316   33.85402  1.000 66.51948  ? 207 GLN B CG  1 
ATOM   3844 C  CD  . GLN B 1 208 ? -15.08372 9.08670   35.19315  1.000 69.57606  ? 207 GLN B CD  1 
ATOM   3845 O  OE1 . GLN B 1 208 ? -14.55001 8.38791   36.05588  1.000 80.12468  ? 207 GLN B OE1 1 
ATOM   3846 N  NE2 . GLN B 1 208 ? -15.33458 10.37929  35.37168  1.000 69.78229  ? 207 GLN B NE2 1 
ATOM   3847 N  N   . THR B 1 209 ? -13.44294 6.30805   29.88391  1.000 59.84913  ? 208 THR B N   1 
ATOM   3848 C  CA  . THR B 1 209 ? -12.31443 6.00537   29.01500  1.000 59.74234  ? 208 THR B CA  1 
ATOM   3849 C  C   . THR B 1 209 ? -12.50077 6.67361   27.65687  1.000 65.98345  ? 208 THR B C   1 
ATOM   3850 O  O   . THR B 1 209 ? -13.60725 6.69878   27.10757  1.000 60.48018  ? 208 THR B O   1 
ATOM   3851 C  CB  . THR B 1 209 ? -12.15887 4.49190   28.83738  1.000 61.76400  ? 208 THR B CB  1 
ATOM   3852 O  OG1 . THR B 1 209 ? -11.94982 3.88045   30.11555  1.000 63.73347  ? 208 THR B OG1 1 
ATOM   3853 C  CG2 . THR B 1 209 ? -10.98894 4.15402   27.92027  1.000 56.08748  ? 208 THR B CG2 1 
ATOM   3854 N  N   . SER B 1 210 ? -11.40924 7.20999   27.11967  1.000 64.69533  ? 209 SER B N   1 
ATOM   3855 C  CA  . SER B 1 210 ? -11.39389 7.84974   25.81458  1.000 65.02840  ? 209 SER B CA  1 
ATOM   3856 C  C   . SER B 1 210 ? -10.62096 6.98453   24.82755  1.000 67.80347  ? 209 SER B C   1 
ATOM   3857 O  O   . SER B 1 210 ? -9.69884  6.25579   25.20458  1.000 71.75144  ? 209 SER B O   1 
ATOM   3858 C  CB  . SER B 1 210 ? -10.75498 9.24151   25.88841  1.000 69.92169  ? 209 SER B CB  1 
ATOM   3859 O  OG  . SER B 1 210 ? -9.38179  9.14592   26.23347  1.000 75.40242  ? 209 SER B OG  1 
ATOM   3860 N  N   . SER B 1 211 ? -11.01395 7.05802   23.56000  1.000 67.13125  ? 210 SER B N   1 
ATOM   3861 C  CA  . SER B 1 211 ? -10.27681 6.39204   22.49617  1.000 59.96154  ? 210 SER B CA  1 
ATOM   3862 C  C   . SER B 1 211 ? -9.05807  7.23929   22.14140  1.000 65.22726  ? 210 SER B C   1 
ATOM   3863 O  O   . SER B 1 211 ? -8.75357  8.23996   22.79601  1.000 72.63642  ? 210 SER B O   1 
ATOM   3864 C  CB  . SER B 1 211 ? -11.17748 6.16818   21.28570  1.000 65.64715  ? 210 SER B CB  1 
ATOM   3865 O  OG  . SER B 1 211 ? -11.05435 7.24644   20.36963  1.000 66.96477  ? 210 SER B OG  1 
ATOM   3866 N  N   . GLU B 1 212 ? -8.34682  6.84695   21.09333  1.000 68.63155  ? 211 GLU B N   1 
ATOM   3867 C  CA  . GLU B 1 212 ? -7.31026  7.68460   20.51753  1.000 74.49674  ? 211 GLU B CA  1 
ATOM   3868 C  C   . GLU B 1 212 ? -7.91223  8.54510   19.41208  1.000 69.35958  ? 211 GLU B C   1 
ATOM   3869 O  O   . GLU B 1 212 ? -9.06669  8.37429   19.01684  1.000 65.31721  ? 211 GLU B O   1 
ATOM   3870 C  CB  . GLU B 1 212 ? -6.16083  6.82877   19.97952  1.000 75.51582  ? 211 GLU B CB  1 
ATOM   3871 C  CG  . GLU B 1 212 ? -6.47946  6.02868   18.71238  1.000 75.43644  ? 211 GLU B CG  1 
ATOM   3872 C  CD  . GLU B 1 212 ? -7.50133  4.92089   18.93301  1.000 86.53861  ? 211 GLU B CD  1 
ATOM   3873 O  OE1 . GLU B 1 212 ? -7.86532  4.64774   20.09675  1.000 78.58572  ? 211 GLU B OE1 1 
ATOM   3874 O  OE2 . GLU B 1 212 ? -7.94900  4.31483   17.93724  1.000 99.66153  ? 211 GLU B OE2 1 
ATOM   3875 N  N   . LYS B 1 213 ? -7.11389  9.47571   18.90180  1.000 72.23750  ? 212 LYS B N   1 
ATOM   3876 C  CA  . LYS B 1 213 ? -7.58505  10.36747  17.85129  1.000 69.10607  ? 212 LYS B CA  1 
ATOM   3877 C  C   . LYS B 1 213 ? -7.51097  9.65181   16.50935  1.000 67.24519  ? 212 LYS B C   1 
ATOM   3878 O  O   . LYS B 1 213 ? -6.44636  9.16558   16.11570  1.000 71.30488  ? 212 LYS B O   1 
ATOM   3879 C  CB  . LYS B 1 213 ? -6.76705  11.65575  17.83794  1.000 73.42652  ? 212 LYS B CB  1 
ATOM   3880 C  CG  . LYS B 1 213 ? -6.89873  12.45926  19.11751  1.000 73.97422  ? 212 LYS B CG  1 
ATOM   3881 C  CD  . LYS B 1 213 ? -6.95195  13.95251  18.83386  1.000 67.26319  ? 212 LYS B CD  1 
ATOM   3882 C  CE  . LYS B 1 213 ? -5.59780  14.48906  18.41319  1.000 70.26540  ? 212 LYS B CE  1 
ATOM   3883 N  NZ  . LYS B 1 213 ? -5.68238  15.93471  18.06831  1.000 78.59145  ? 212 LYS B NZ  1 
ATOM   3884 N  N   . ILE B 1 214 ? -8.64006  9.58840   15.81017  1.000 66.10841  ? 213 ILE B N   1 
ATOM   3885 C  CA  . ILE B 1 214 ? -8.75552  8.87698   14.54305  1.000 61.56077  ? 213 ILE B CA  1 
ATOM   3886 C  C   . ILE B 1 214 ? -8.87340  9.90200   13.42408  1.000 70.14508  ? 213 ILE B C   1 
ATOM   3887 O  O   . ILE B 1 214 ? -9.65692  10.85442  13.52650  1.000 66.57061  ? 213 ILE B O   1 
ATOM   3888 C  CB  . ILE B 1 214 ? -9.96163  7.92279   14.54409  1.000 62.67752  ? 213 ILE B CB  1 
ATOM   3889 C  CG1 . ILE B 1 214 ? -9.93990  7.04110   15.79367  1.000 61.98562  ? 213 ILE B CG1 1 
ATOM   3890 C  CG2 . ILE B 1 214 ? -9.96363  7.07342   13.28601  1.000 56.15581  ? 213 ILE B CG2 1 
ATOM   3891 C  CD1 . ILE B 1 214 ? -11.24283 6.31930   16.05323  1.000 56.50762  ? 213 ILE B CD1 1 
ATOM   3892 N  N   . SER B 1 215 ? -8.09556  9.70930   12.35965  1.000 66.80845  ? 214 SER B N   1 
ATOM   3893 C  CA  . SER B 1 215 ? -8.12869  10.60273  11.21111  1.000 58.97916  ? 214 SER B CA  1 
ATOM   3894 C  C   . SER B 1 215 ? -7.88837  9.79415   9.94583   1.000 64.56217  ? 214 SER B C   1 
ATOM   3895 O  O   . SER B 1 215 ? -7.08968  8.85449   9.94660   1.000 68.63701  ? 214 SER B O   1 
ATOM   3896 C  CB  . SER B 1 215 ? -7.08240  11.71465  11.33778  1.000 67.38605  ? 214 SER B CB  1 
ATOM   3897 O  OG  . SER B 1 215 ? -5.77224  11.17467  11.40410  1.000 72.87051  ? 214 SER B OG  1 
ATOM   3898 N  N   . LEU B 1 216 ? -8.58872  10.15921  8.87825   1.000 59.06480  ? 215 LEU B N   1 
ATOM   3899 C  CA  . LEU B 1 216 ? -8.48263  9.48746   7.59338   1.000 63.01698  ? 215 LEU B CA  1 
ATOM   3900 C  C   . LEU B 1 216 ? -7.68481  10.33313  6.60720   1.000 63.02409  ? 215 LEU B C   1 
ATOM   3901 O  O   . LEU B 1 216 ? -7.57380  11.55398  6.74200   1.000 70.06661  ? 215 LEU B O   1 
ATOM   3902 C  CB  . LEU B 1 216 ? -9.87558  9.18813   7.03087   1.000 64.15593  ? 215 LEU B CB  1 
ATOM   3903 C  CG  . LEU B 1 216 ? -10.73010 8.18690   7.81647   1.000 64.60876  ? 215 LEU B CG  1 
ATOM   3904 C  CD1 . LEU B 1 216 ? -12.18250 8.24162   7.36846   1.000 58.91038  ? 215 LEU B CD1 1 
ATOM   3905 C  CD2 . LEU B 1 216 ? -10.18114 6.77583   7.66373   1.000 63.12997  ? 215 LEU B CD2 1 
ATOM   3906 N  N   . SER B 1 217 ? -7.12065  9.65852   5.61261   1.000 61.99060  ? 216 SER B N   1 
ATOM   3907 C  CA  . SER B 1 217 ? -6.38043  10.28749  4.53020   1.000 71.95933  ? 216 SER B CA  1 
ATOM   3908 C  C   . SER B 1 217 ? -7.21681  10.24092  3.25948   1.000 67.50426  ? 216 SER B C   1 
ATOM   3909 O  O   . SER B 1 217 ? -8.23222  9.54428   3.19174   1.000 68.10621  ? 216 SER B O   1 
ATOM   3910 C  CB  . SER B 1 217 ? -5.03382  9.58718   4.31337   1.000 77.19164  ? 216 SER B CB  1 
ATOM   3911 O  OG  . SER B 1 217 ? -5.21191  8.22738   3.94852   1.000 75.12613  ? 216 SER B OG  1 
ATOM   3912 N  N   . SER B 1 218 ? -6.78280  10.99543  2.24364   1.000 71.86001  ? 217 SER B N   1 
ATOM   3913 C  CA  . SER B 1 218 ? -7.47843  10.96063  0.95969   1.000 74.61884  ? 217 SER B CA  1 
ATOM   3914 C  C   . SER B 1 218 ? -7.63164  9.52582   0.46529   1.000 71.09869  ? 217 SER B C   1 
ATOM   3915 O  O   . SER B 1 218 ? -8.71461  9.12374   0.01545   1.000 69.01805  ? 217 SER B O   1 
ATOM   3916 C  CB  . SER B 1 218 ? -6.72780  11.80891  -0.06860  1.000 73.00206  ? 217 SER B CB  1 
ATOM   3917 O  OG  . SER B 1 218 ? -5.45933  11.25037  -0.36729  1.000 78.25606  ? 217 SER B OG  1 
ATOM   3918 N  N   . GLU B 1 219 ? -6.56550  8.72629   0.58582   1.000 74.76895  ? 218 GLU B N   1 
ATOM   3919 C  CA  . GLU B 1 219 ? -6.64665  7.30882   0.24239   1.000 70.35086  ? 218 GLU B CA  1 
ATOM   3920 C  C   . GLU B 1 219 ? -7.68857  6.59573   1.09781   1.000 72.44208  ? 218 GLU B C   1 
ATOM   3921 O  O   . GLU B 1 219 ? -8.55236  5.87594   0.57964   1.000 71.14602  ? 218 GLU B O   1 
ATOM   3922 C  CB  . GLU B 1 219 ? -5.28158  6.64076   0.41956   1.000 73.08847  ? 218 GLU B CB  1 
ATOM   3923 C  CG  . GLU B 1 219 ? -4.15371  7.24753   -0.38417  1.000 79.03785  ? 218 GLU B CG  1 
ATOM   3924 C  CD  . GLU B 1 219 ? -3.37500  8.28375   0.39570   1.000 89.80752  ? 218 GLU B CD  1 
ATOM   3925 O  OE1 . GLU B 1 219 ? -3.98455  9.28121   0.83608   1.000 90.22747  ? 218 GLU B OE1 1 
ATOM   3926 O  OE2 . GLU B 1 219 ? -2.15196  8.10243   0.57286   1.000 89.45448  ? 218 GLU B OE2 1 
ATOM   3927 N  N   . ALA B 1 220 ? -7.61579  6.77786   2.41997   1.000 69.82315  ? 219 ALA B N   1 
ATOM   3928 C  CA  . ALA B 1 220 ? -8.55632  6.10653   3.30982   1.000 66.41153  ? 219 ALA B CA  1 
ATOM   3929 C  C   . ALA B 1 220 ? -9.98218  6.58708   3.08859   1.000 64.93496  ? 219 ALA B C   1 
ATOM   3930 O  O   . ALA B 1 220 ? -10.92125 5.78411   3.15336   1.000 62.76914  ? 219 ALA B O   1 
ATOM   3931 C  CB  . ALA B 1 220 ? -8.14170  6.31818   4.76311   1.000 66.10745  ? 219 ALA B CB  1 
ATOM   3932 N  N   . ILE B 1 221 ? -10.16365 7.88418   2.82940   1.000 58.33951  ? 220 ILE B N   1 
ATOM   3933 C  CA  . ILE B 1 221 ? -11.49959 8.41371   2.57688   1.000 60.79328  ? 220 ILE B CA  1 
ATOM   3934 C  C   . ILE B 1 221 ? -12.09371 7.77092   1.32973   1.000 66.73094  ? 220 ILE B C   1 
ATOM   3935 O  O   . ILE B 1 221 ? -13.25588 7.33724   1.32469   1.000 63.91101  ? 220 ILE B O   1 
ATOM   3936 C  CB  . ILE B 1 221 ? -11.45321 9.94917   2.46174   1.000 68.02173  ? 220 ILE B CB  1 
ATOM   3937 C  CG1 . ILE B 1 221 ? -11.04359 10.57002  3.79983   1.000 65.26744  ? 220 ILE B CG1 1 
ATOM   3938 C  CG2 . ILE B 1 221 ? -12.80822 10.49550  2.02740   1.000 64.69631  ? 220 ILE B CG2 1 
ATOM   3939 C  CD1 . ILE B 1 221 ? -10.50366 11.97840  3.68732   1.000 74.54061  ? 220 ILE B CD1 1 
ATOM   3940 N  N   . GLU B 1 222 ? -11.29994 7.68726   0.25581   1.000 59.38147  ? 221 GLU B N   1 
ATOM   3941 C  CA  . GLU B 1 222 ? -11.79835 7.06388   -0.96452  1.000 68.41183  ? 221 GLU B CA  1 
ATOM   3942 C  C   . GLU B 1 222 ? -12.09251 5.58330   -0.74613  1.000 64.58356  ? 221 GLU B C   1 
ATOM   3943 O  O   . GLU B 1 222 ? -13.06014 5.04671   -1.30664  1.000 60.94952  ? 221 GLU B O   1 
ATOM   3944 C  CB  . GLU B 1 222 ? -10.78701 7.24929   -2.09420  1.000 73.85780  ? 221 GLU B CB  1 
ATOM   3945 C  CG  . GLU B 1 222 ? -11.39990 7.41641   -3.47679  1.000 69.19214  ? 221 GLU B CG  1 
ATOM   3946 C  CD  . GLU B 1 222 ? -11.92744 8.81994   -3.71824  1.000 82.05601  ? 221 GLU B CD  1 
ATOM   3947 O  OE1 . GLU B 1 222 ? -11.75239 9.69553   -2.83890  1.000 88.34193  ? 221 GLU B OE1 1 
ATOM   3948 O  OE2 . GLU B 1 222 ? -12.51430 9.05304   -4.79504  1.000 83.85285  ? 221 GLU B OE2 1 
ATOM   3949 N  N   . ALA B 1 223 ? -11.28139 4.90908   0.07706   1.000 66.76537  ? 222 ALA B N   1 
ATOM   3950 C  CA  . ALA B 1 223 ? -11.53796 3.49958   0.35961   1.000 64.49123  ? 222 ALA B CA  1 
ATOM   3951 C  C   . ALA B 1 223 ? -12.85454 3.31263   1.11047   1.000 56.88935  ? 222 ALA B C   1 
ATOM   3952 O  O   . ALA B 1 223 ? -13.64555 2.41119   0.78594   1.000 66.68261  ? 222 ALA B O   1 
ATOM   3953 C  CB  . ALA B 1 223 ? -10.37283 2.90949   1.15025   1.000 52.38800  ? 222 ALA B CB  1 
ATOM   3954 N  N   . VAL B 1 224 ? -13.10643 4.15053   2.11849   1.000 47.95062  ? 223 VAL B N   1 
ATOM   3955 C  CA  . VAL B 1 224 ? -14.36191 4.05079   2.85757   1.000 57.26747  ? 223 VAL B CA  1 
ATOM   3956 C  C   . VAL B 1 224 ? -15.53492 4.31517   1.92813   1.000 50.34708  ? 223 VAL B C   1 
ATOM   3957 O  O   . VAL B 1 224 ? -16.56777 3.63316   1.99563   1.000 51.76217  ? 223 VAL B O   1 
ATOM   3958 C  CB  . VAL B 1 224 ? -14.36715 5.00863   4.06389   1.000 47.26490  ? 223 VAL B CB  1 
ATOM   3959 C  CG1 . VAL B 1 224 ? -15.72656 4.96581   4.76305   1.000 43.99245  ? 223 VAL B CG1 1 
ATOM   3960 C  CG2 . VAL B 1 224 ? -13.24971 4.64693   5.02406   1.000 49.09471  ? 223 VAL B CG2 1 
ATOM   3961 N  N   . LYS B 1 225 ? -15.38883 5.29913   1.03485   1.000 52.87535  ? 224 LYS B N   1 
ATOM   3962 C  CA  . LYS B 1 225 ? -16.44892 5.57598   0.07182   1.000 59.60889  ? 224 LYS B CA  1 
ATOM   3963 C  C   . LYS B 1 225 ? -16.72528 4.36259   -0.80822  1.000 57.07216  ? 224 LYS B C   1 
ATOM   3964 O  O   . LYS B 1 225 ? -17.88909 4.01591   -1.05441  1.000 56.87093  ? 224 LYS B O   1 
ATOM   3965 C  CB  . LYS B 1 225 ? -16.07810 6.78827   -0.78042  1.000 64.45858  ? 224 LYS B CB  1 
ATOM   3966 C  CG  . LYS B 1 225 ? -16.60078 8.10169   -0.22729  1.000 61.28235  ? 224 LYS B CG  1 
ATOM   3967 C  CD  . LYS B 1 225 ? -16.35092 9.25639   -1.18273  1.000 59.24343  ? 224 LYS B CD  1 
ATOM   3968 C  CE  . LYS B 1 225 ? -15.05474 9.97174   -0.85999  1.000 69.83411  ? 224 LYS B CE  1 
ATOM   3969 N  NZ  . LYS B 1 225 ? -15.00701 11.31030  -1.51304  1.000 74.12509  ? 224 LYS B NZ  1 
ATOM   3970 N  N   . ILE B 1 226 ? -15.66672 3.69229   -1.27140  1.000 51.13167  ? 225 ILE B N   1 
ATOM   3971 C  CA  . ILE B 1 226 ? -15.84000 2.51103   -2.11579  1.000 62.16439  ? 225 ILE B CA  1 
ATOM   3972 C  C   . ILE B 1 226 ? -16.63771 1.43725   -1.38144  1.000 60.40621  ? 225 ILE B C   1 
ATOM   3973 O  O   . ILE B 1 226 ? -17.62980 0.90593   -1.90514  1.000 63.24321  ? 225 ILE B O   1 
ATOM   3974 C  CB  . ILE B 1 226 ? -14.47279 1.97117   -2.57417  1.000 65.14005  ? 225 ILE B CB  1 
ATOM   3975 C  CG1 . ILE B 1 226 ? -13.81350 2.92349   -3.57522  1.000 62.62262  ? 225 ILE B CG1 1 
ATOM   3976 C  CG2 . ILE B 1 226 ? -14.63084 0.58177   -3.17776  1.000 55.02550  ? 225 ILE B CG2 1 
ATOM   3977 C  CD1 . ILE B 1 226 ? -12.49634 2.41523   -4.11074  1.000 56.88197  ? 225 ILE B CD1 1 
ATOM   3978 N  N   . GLU B 1 227 ? -16.22203 1.10462   -0.15235  1.000 56.79448  ? 226 GLU B N   1 
ATOM   3979 C  CA  . GLU B 1 227 ? -16.90370 0.02000   0.55624   1.000 58.07060  ? 226 GLU B CA  1 
ATOM   3980 C  C   . GLU B 1 227 ? -18.35359 0.38392   0.86165   1.000 57.08258  ? 226 GLU B C   1 
ATOM   3981 O  O   . GLU B 1 227 ? -19.24835 -0.46891  0.76778   1.000 53.61005  ? 226 GLU B O   1 
ATOM   3982 C  CB  . GLU B 1 227 ? -16.17274 -0.36458  1.84554   1.000 62.14887  ? 226 GLU B CB  1 
ATOM   3983 C  CG  . GLU B 1 227 ? -16.75131 -1.64558  2.45340   1.000 67.36284  ? 226 GLU B CG  1 
ATOM   3984 C  CD  . GLU B 1 227 ? -16.11224 -2.05998  3.76447   1.000 74.15159  ? 226 GLU B CD  1 
ATOM   3985 O  OE1 . GLU B 1 227 ? -15.22305 -1.34346  4.26895   1.000 85.46820  ? 226 GLU B OE1 1 
ATOM   3986 O  OE2 . GLU B 1 227 ? -16.50571 -3.11637  4.29910   1.000 79.26592  ? 226 GLU B OE2 1 
ATOM   3987 N  N   . LEU B 1 228 ? -18.61063 1.64532   1.22613   1.000 55.05805  ? 227 LEU B N   1 
ATOM   3988 C  CA  . LEU B 1 228 ? -19.98019 2.04463   1.53860   1.000 56.03455  ? 227 LEU B CA  1 
ATOM   3989 C  C   . LEU B 1 228 ? -20.87549 1.97836   0.30699   1.000 55.51253  ? 227 LEU B C   1 
ATOM   3990 O  O   . LEU B 1 228 ? -22.03899 1.55681   0.39719   1.000 58.17817  ? 227 LEU B O   1 
ATOM   3991 C  CB  . LEU B 1 228 ? -19.99039 3.44004   2.15325   1.000 52.61938  ? 227 LEU B CB  1 
ATOM   3992 C  CG  . LEU B 1 228 ? -19.32901 3.46867   3.53039   1.000 57.50666  ? 227 LEU B CG  1 
ATOM   3993 C  CD1 . LEU B 1 228 ? -19.58199 4.79764   4.20888   1.000 53.59997  ? 227 LEU B CD1 1 
ATOM   3994 C  CD2 . LEU B 1 228 ? -19.81558 2.30429   4.38934   1.000 56.33343  ? 227 LEU B CD2 1 
ATOM   3995 N  N   . ALA B 1 229 ? -20.34956 2.37932   -0.85625  1.000 56.23023  ? 228 ALA B N   1 
ATOM   3996 C  CA  . ALA B 1 229 ? -21.11142 2.22068   -2.09046  1.000 60.10248  ? 228 ALA B CA  1 
ATOM   3997 C  C   . ALA B 1 229 ? -21.41403 0.75038   -2.36457  1.000 55.91149  ? 228 ALA B C   1 
ATOM   3998 O  O   . ALA B 1 229 ? -22.54482 0.39800   -2.73490  1.000 57.01151  ? 228 ALA B O   1 
ATOM   3999 C  CB  . ALA B 1 229 ? -20.34884 2.84453   -3.25804  1.000 57.84272  ? 228 ALA B CB  1 
ATOM   4000 N  N   . SER B 1 230 ? -20.41791 -0.12320  -2.17676  1.000 57.44131  ? 229 SER B N   1 
ATOM   4001 C  CA  . SER B 1 230 ? -20.62890 -1.55117  -2.41023  1.000 57.85327  ? 229 SER B CA  1 
ATOM   4002 C  C   . SER B 1 230 ? -21.75100 -2.09118  -1.52916  1.000 61.74427  ? 229 SER B C   1 
ATOM   4003 O  O   . SER B 1 230 ? -22.65126 -2.79907  -2.00301  1.000 63.41943  ? 229 SER B O   1 
ATOM   4004 C  CB  . SER B 1 230 ? -19.33284 -2.31837  -2.15114  1.000 59.22748  ? 229 SER B CB  1 
ATOM   4005 O  OG  . SER B 1 230 ? -18.23876 -1.69880  -2.80144  1.000 82.63086  ? 229 SER B OG  1 
ATOM   4006 N  N   . LEU B 1 231 ? -21.71672 -1.75420  -0.23726  1.000 52.26281  ? 230 LEU B N   1 
ATOM   4007 C  CA  . LEU B 1 231 ? -22.72121 -2.27236  0.68715   1.000 56.06646  ? 230 LEU B CA  1 
ATOM   4008 C  C   . LEU B 1 231 ? -24.10466 -1.69774  0.40899   1.000 53.22247  ? 230 LEU B C   1 
ATOM   4009 O  O   . LEU B 1 231 ? -25.10637 -2.40183  0.57878   1.000 54.34351  ? 230 LEU B O   1 
ATOM   4010 C  CB  . LEU B 1 231 ? -22.31511 -1.97924  2.12862   1.000 54.89418  ? 230 LEU B CB  1 
ATOM   4011 C  CG  . LEU B 1 231 ? -20.92917 -2.45467  2.54669   1.000 50.35961  ? 230 LEU B CG  1 
ATOM   4012 C  CD1 . LEU B 1 231 ? -20.67595 -2.00705  3.95039   1.000 58.78199  ? 230 LEU B CD1 1 
ATOM   4013 C  CD2 . LEU B 1 231 ? -20.80780 -3.95793  2.42848   1.000 49.01357  ? 230 LEU B CD2 1 
ATOM   4014 N  N   . ALA B 1 232 ? -24.19345 -0.42515  0.00904   1.000 49.96208  ? 231 ALA B N   1 
ATOM   4015 C  CA  . ALA B 1 232 ? -25.50042 0.11325   -0.35214  1.000 52.72757  ? 231 ALA B CA  1 
ATOM   4016 C  C   . ALA B 1 232 ? -26.07648 -0.62098  -1.55654  1.000 51.91515  ? 231 ALA B C   1 
ATOM   4017 O  O   . ALA B 1 232 ? -27.27115 -0.96794  -1.57280  1.000 53.06505  ? 231 ALA B O   1 
ATOM   4018 C  CB  . ALA B 1 232 ? -25.39082 1.60666   -0.63487  1.000 53.03917  ? 231 ALA B CB  1 
ATOM   4019 N  N   . LYS B 1 233 ? -25.23497 -0.88506  -2.56489  1.000 56.22368  ? 232 LYS B N   1 
ATOM   4020 C  CA  . LYS B 1 233 ? -25.69577 -1.65047  -3.71896  1.000 63.34733  ? 232 LYS B CA  1 
ATOM   4021 C  C   . LYS B 1 233 ? -26.22561 -3.00795  -3.28248  1.000 65.43706  ? 232 LYS B C   1 
ATOM   4022 O  O   . LYS B 1 233 ? -27.32579 -3.41643  -3.67476  1.000 57.47500  ? 232 LYS B O   1 
ATOM   4023 C  CB  . LYS B 1 233 ? -24.56202 -1.83491  -4.72730  1.000 61.23421  ? 232 LYS B CB  1 
ATOM   4024 C  CG  . LYS B 1 233 ? -24.17229 -0.59377  -5.49476  1.000 66.37505  ? 232 LYS B CG  1 
ATOM   4025 C  CD  . LYS B 1 233 ? -22.96519 -0.88058  -6.36444  1.000 67.20119  ? 232 LYS B CD  1 
ATOM   4026 C  CE  . LYS B 1 233 ? -22.33632 0.39872   -6.87922  1.000 64.98284  ? 232 LYS B CE  1 
ATOM   4027 N  NZ  . LYS B 1 233 ? -20.98899 0.11911   -7.44632  1.000 66.85382  ? 232 LYS B NZ  1 
ATOM   4028 N  N   . LYS B 1 234 ? -25.45237 -3.71361  -2.45072  1.000 59.39536  ? 233 LYS B N   1 
ATOM   4029 C  CA  . LYS B 1 234 ? -25.84418 -5.05545  -2.03036  1.000 57.16432  ? 233 LYS B CA  1 
ATOM   4030 C  C   . LYS B 1 234 ? -27.13026 -5.03346  -1.20811  1.000 57.63773  ? 233 LYS B C   1 
ATOM   4031 O  O   . LYS B 1 234 ? -27.98307 -5.91690  -1.35150  1.000 53.83701  ? 233 LYS B O   1 
ATOM   4032 C  CB  . LYS B 1 234 ? -24.70326 -5.69857  -1.24982  1.000 62.34931  ? 233 LYS B CB  1 
ATOM   4033 C  CG  . LYS B 1 234 ? -24.74798 -7.21811  -1.21314  1.000 70.39588  ? 233 LYS B CG  1 
ATOM   4034 C  CD  . LYS B 1 234 ? -23.44479 -7.78971  -0.68953  1.000 79.83047  ? 233 LYS B CD  1 
ATOM   4035 C  CE  . LYS B 1 234 ? -22.27328 -7.28995  -1.51254  1.000 74.48437  ? 233 LYS B CE  1 
ATOM   4036 N  NZ  . LYS B 1 234 ? -20.99585 -7.88253  -1.04431  1.000 86.38721  ? 233 LYS B NZ  1 
ATOM   4037 N  N   . HIS B 1 235 ? -27.28808 -4.03243  -0.34082  1.000 55.82355  ? 234 HIS B N   1 
ATOM   4038 C  CA  . HIS B 1 235 ? -28.49954 -3.92806  0.46610   1.000 56.89853  ? 234 HIS B CA  1 
ATOM   4039 C  C   . HIS B 1 235 ? -29.73025 -3.72699  -0.40721  1.000 56.14144  ? 234 HIS B C   1 
ATOM   4040 O  O   . HIS B 1 235 ? -30.76282 -4.38040  -0.20056  1.000 56.57605  ? 234 HIS B O   1 
ATOM   4041 C  CB  . HIS B 1 235 ? -28.34711 -2.77946  1.46576   1.000 57.63994  ? 234 HIS B CB  1 
ATOM   4042 C  CG  . HIS B 1 235 ? -29.55334 -2.54721  2.32377   1.000 53.63675  ? 234 HIS B CG  1 
ATOM   4043 N  ND1 . HIS B 1 235 ? -30.10578 -3.53135  3.11535   1.000 51.53674  ? 234 HIS B ND1 1 
ATOM   4044 C  CD2 . HIS B 1 235 ? -30.30199 -1.43709  2.52708   1.000 52.30753  ? 234 HIS B CD2 1 
ATOM   4045 C  CE1 . HIS B 1 235 ? -31.14506 -3.04043  3.76690   1.000 55.75967  ? 234 HIS B CE1 1 
ATOM   4046 N  NE2 . HIS B 1 235 ? -31.28539 -1.77165  3.42758   1.000 58.07158  ? 234 HIS B NE2 1 
ATOM   4047 N  N   . GLN B 1 236 ? -29.63608 -2.84160  -1.40384  1.000 55.39464  ? 235 GLN B N   1 
ATOM   4048 C  CA  . GLN B 1 236 ? -30.78045 -2.64277  -2.29035  1.000 56.95936  ? 235 GLN B CA  1 
ATOM   4049 C  C   . GLN B 1 236 ? -31.03622 -3.87608  -3.14988  1.000 54.84325  ? 235 GLN B C   1 
ATOM   4050 O  O   . GLN B 1 236 ? -32.19928 -4.21776  -3.41421  1.000 58.12848  ? 235 GLN B O   1 
ATOM   4051 C  CB  . GLN B 1 236 ? -30.57316 -1.40348  -3.16639  1.000 58.96329  ? 235 GLN B CB  1 
ATOM   4052 C  CG  . GLN B 1 236 ? -30.58344 -0.08756  -2.39749  1.000 54.03426  ? 235 GLN B CG  1 
ATOM   4053 C  CD  . GLN B 1 236 ? -31.89576 0.15632   -1.67711  1.000 54.34373  ? 235 GLN B CD  1 
ATOM   4054 O  OE1 . GLN B 1 236 ? -31.91555 0.49445   -0.49445  1.000 55.05677  ? 235 GLN B OE1 1 
ATOM   4055 N  NE2 . GLN B 1 236 ? -33.00119 -0.00453  -2.39291  1.000 46.97627  ? 235 GLN B NE2 1 
ATOM   4056 N  N   . GLN B 1 237 ? -29.97007 -4.57504  -3.55686  1.000 57.16165  ? 236 GLN B N   1 
ATOM   4057 C  CA  . GLN B 1 237 ? -30.13828 -5.82505  -4.29050  1.000 64.80474  ? 236 GLN B CA  1 
ATOM   4058 C  C   . GLN B 1 237 ? -30.91294 -6.84186  -3.46383  1.000 62.87549  ? 236 GLN B C   1 
ATOM   4059 O  O   . GLN B 1 237 ? -31.82278 -7.50758  -3.97386  1.000 64.65106  ? 236 GLN B O   1 
ATOM   4060 C  CB  . GLN B 1 237 ? -28.77713 -6.40806  -4.67021  1.000 61.48880  ? 236 GLN B CB  1 
ATOM   4061 C  CG  . GLN B 1 237 ? -27.99504 -5.65643  -5.72792  1.000 65.83661  ? 236 GLN B CG  1 
ATOM   4062 C  CD  . GLN B 1 237 ? -26.68479 -6.34891  -6.05520  1.000 78.18918  ? 236 GLN B CD  1 
ATOM   4063 O  OE1 . GLN B 1 237 ? -26.66424 -7.53410  -6.38494  1.000 84.76867  ? 236 GLN B OE1 1 
ATOM   4064 N  NE2 . GLN B 1 237 ? -25.58203 -5.61780  -5.94539  1.000 74.41718  ? 236 GLN B NE2 1 
ATOM   4065 N  N   . GLN B 1 238 ? -30.57014 -6.96774  -2.17799  1.000 54.65368  ? 237 GLN B N   1 
ATOM   4066 C  CA  . GLN B 1 238 ? -31.23078 -7.95596  -1.33110  1.000 55.16488  ? 237 GLN B CA  1 
ATOM   4067 C  C   . GLN B 1 238 ? -32.68015 -7.57308  -1.05300  1.000 54.73651  ? 237 GLN B C   1 
ATOM   4068 O  O   . GLN B 1 238 ? -33.56285 -8.44070  -1.01785  1.000 57.01861  ? 237 GLN B O   1 
ATOM   4069 C  CB  . GLN B 1 238 ? -30.44865 -8.12814  -0.03241  1.000 57.59763  ? 237 GLN B CB  1 
ATOM   4070 C  CG  . GLN B 1 238 ? -29.04189 -8.67906  -0.24036  1.000 57.11644  ? 237 GLN B CG  1 
ATOM   4071 C  CD  . GLN B 1 238 ? -28.31990 -8.97577  1.05957   1.000 61.77862  ? 237 GLN B CD  1 
ATOM   4072 O  OE1 . GLN B 1 238 ? -28.90752 -8.92063  2.13868   1.000 65.59486  ? 237 GLN B OE1 1 
ATOM   4073 N  NE2 . GLN B 1 238 ? -27.03291 -9.29620  0.95957   1.000 58.31074  ? 237 GLN B NE2 1 
ATOM   4074 N  N   . LEU B 1 239 ? -32.94794 -6.28089  -0.85345  1.000 61.06255  ? 238 LEU B N   1 
ATOM   4075 C  CA  . LEU B 1 239 ? -34.33022 -5.84271  -0.67367  1.000 66.81937  ? 238 LEU B CA  1 
ATOM   4076 C  C   . LEU B 1 239 ? -35.16996 -6.14386  -1.91252  1.000 60.66578  ? 238 LEU B C   1 
ATOM   4077 O  O   . LEU B 1 239 ? -36.32012 -6.60294  -1.80507  1.000 59.95882  ? 238 LEU B O   1 
ATOM   4078 C  CB  . LEU B 1 239 ? -34.36647 -4.35076  -0.34016  1.000 54.94917  ? 238 LEU B CB  1 
ATOM   4079 C  CG  . LEU B 1 239 ? -33.69700 -3.93786  0.97038   1.000 57.18533  ? 238 LEU B CG  1 
ATOM   4080 C  CD1 . LEU B 1 239 ? -33.75318 -2.43839  1.14878   1.000 57.55282  ? 238 LEU B CD1 1 
ATOM   4081 C  CD2 . LEU B 1 239 ? -34.36302 -4.62588  2.13450   1.000 56.65447  ? 238 LEU B CD2 1 
ATOM   4082 N  N   . GLN B 1 240 ? -34.60984 -5.89518  -3.10259  1.000 56.51366  ? 239 GLN B N   1 
ATOM   4083 C  CA  . GLN B 1 240 ? -35.33592 -6.21201  -4.32841  1.000 63.75358  ? 239 GLN B CA  1 
ATOM   4084 C  C   . GLN B 1 240 ? -35.51960 -7.71691  -4.49323  1.000 59.10155  ? 239 GLN B C   1 
ATOM   4085 O  O   . GLN B 1 240 ? -36.54099 -8.16930  -5.02287  1.000 57.64888  ? 239 GLN B O   1 
ATOM   4086 C  CB  . GLN B 1 240 ? -34.61865 -5.62771  -5.54124  1.000 61.61039  ? 239 GLN B CB  1 
ATOM   4087 C  CG  . GLN B 1 240 ? -35.35742 -5.85641  -6.84633  1.000 63.88452  ? 239 GLN B CG  1 
ATOM   4088 C  CD  . GLN B 1 240 ? -36.65821 -5.08893  -6.91294  1.000 69.84256  ? 239 GLN B CD  1 
ATOM   4089 O  OE1 . GLN B 1 240 ? -37.71372 -5.65057  -7.20785  1.000 71.90035  ? 239 GLN B OE1 1 
ATOM   4090 N  NE2 . GLN B 1 240 ? -36.58729 -3.78982  -6.64962  1.000 75.64727  ? 239 GLN B NE2 1 
ATOM   4091 N  N   . LYS B 1 241 ? -34.52959 -8.50846  -4.07338  1.000 54.36660  ? 240 LYS B N   1 
ATOM   4092 C  CA  . LYS B 1 241 ? -34.67891 -9.96081  -4.11271  1.000 59.62883  ? 240 LYS B CA  1 
ATOM   4093 C  C   . LYS B 1 241 ? -35.83641 -10.41088 -3.22867  1.000 59.68958  ? 240 LYS B C   1 
ATOM   4094 O  O   . LYS B 1 241 ? -36.62276 -11.28844 -3.60524  1.000 59.37544  ? 240 LYS B O   1 
ATOM   4095 C  CB  . LYS B 1 241 ? -33.37574 -10.63908 -3.68632  1.000 53.16992  ? 240 LYS B CB  1 
ATOM   4096 C  CG  . LYS B 1 241 ? -33.02145 -11.88142 -4.49640  1.000 56.79333  ? 240 LYS B CG  1 
ATOM   4097 C  CD  . LYS B 1 241 ? -31.82537 -12.61304 -3.89551  1.000 66.20205  ? 240 LYS B CD  1 
ATOM   4098 C  CE  . LYS B 1 241 ? -31.38139 -13.79832 -4.74750  1.000 54.76085  ? 240 LYS B CE  1 
ATOM   4099 N  NZ  . LYS B 1 241 ? -30.60546 -13.37309 -5.94605  1.000 64.50859  ? 240 LYS B NZ  1 
ATOM   4100 N  N   . TYR B 1 242 ? -35.94825 -9.81924  -2.03666  1.000 59.52427  ? 241 TYR B N   1 
ATOM   4101 C  CA  . TYR B 1 242 ? -37.06976 -10.14815 -1.15953  1.000 60.38143  ? 241 TYR B CA  1 
ATOM   4102 C  C   . TYR B 1 242 ? -38.39976 -9.74266  -1.78479  1.000 62.19929  ? 241 TYR B C   1 
ATOM   4103 O  O   . TYR B 1 242 ? -39.40052 -10.45835 -1.65391  1.000 61.28508  ? 241 TYR B O   1 
ATOM   4104 C  CB  . TYR B 1 242 ? -36.89339 -9.49114  0.21298   1.000 65.59390  ? 241 TYR B CB  1 
ATOM   4105 C  CG  . TYR B 1 242 ? -37.97330 -9.87046  1.20811   1.000 56.64107  ? 241 TYR B CG  1 
ATOM   4106 C  CD1 . TYR B 1 242 ? -38.31569 -11.19954 1.41618   1.000 67.38314  ? 241 TYR B CD1 1 
ATOM   4107 C  CD2 . TYR B 1 242 ? -38.64315 -8.90222  1.94327   1.000 58.43866  ? 241 TYR B CD2 1 
ATOM   4108 C  CE1 . TYR B 1 242 ? -39.30050 -11.55376 2.32167   1.000 63.60073  ? 241 TYR B CE1 1 
ATOM   4109 C  CE2 . TYR B 1 242 ? -39.62944 -9.24891  2.85774   1.000 64.85554  ? 241 TYR B CE2 1 
ATOM   4110 C  CZ  . TYR B 1 242 ? -39.95230 -10.57570 3.04083   1.000 65.14472  ? 241 TYR B CZ  1 
ATOM   4111 O  OH  . TYR B 1 242 ? -40.92772 -10.93764 3.94305   1.000 62.66926  ? 241 TYR B OH  1 
ATOM   4112 N  N   . LYS B 1 243 ? -38.43705 -8.59011  -2.45669  1.000 61.79666  ? 242 LYS B N   1 
ATOM   4113 C  CA  . LYS B 1 243 ? -39.67645 -8.19713  -3.12424  1.000 68.74883  ? 242 LYS B CA  1 
ATOM   4114 C  C   . LYS B 1 243 ? -39.99313 -9.11111  -4.30689  1.000 67.17634  ? 242 LYS B C   1 
ATOM   4115 O  O   . LYS B 1 243 ? -41.16834 -9.30592  -4.64159  1.000 68.02163  ? 242 LYS B O   1 
ATOM   4116 C  CB  . LYS B 1 243 ? -39.60791 -6.73928  -3.58543  1.000 71.14713  ? 242 LYS B CB  1 
ATOM   4117 C  CG  . LYS B 1 243 ? -40.95011 -6.18746  -4.05069  1.000 79.48204  ? 242 LYS B CG  1 
ATOM   4118 C  CD  . LYS B 1 243 ? -40.90397 -4.69092  -4.31693  1.000 95.11348  ? 242 LYS B CD  1 
ATOM   4119 C  CE  . LYS B 1 243 ? -42.24396 -4.18299  -4.83787  1.000 97.71100  ? 242 LYS B CE  1 
ATOM   4120 N  NZ  . LYS B 1 243 ? -42.22896 -2.71493  -5.10031  1.000 93.96428  ? 242 LYS B NZ  1 
ATOM   4121 N  N   . ASP B 1 244 ? -38.96773 -9.68696  -4.94170  1.000 64.27504  ? 243 ASP B N   1 
ATOM   4122 C  CA  . ASP B 1 244 ? -39.17302 -10.62145 -6.04187  1.000 60.97936  ? 243 ASP B CA  1 
ATOM   4123 C  C   . ASP B 1 244 ? -39.46655 -12.03194 -5.55972  1.000 65.62128  ? 243 ASP B C   1 
ATOM   4124 O  O   . ASP B 1 244 ? -40.06389 -12.81638 -6.30426  1.000 64.91127  ? 243 ASP B O   1 
ATOM   4125 C  CB  . ASP B 1 244 ? -37.94475 -10.64299 -6.95268  1.000 53.88585  ? 243 ASP B CB  1 
ATOM   4126 C  CG  . ASP B 1 244 ? -37.77626 -9.35352  -7.72738  1.000 58.99407  ? 243 ASP B CG  1 
ATOM   4127 O  OD1 . ASP B 1 244 ? -38.72682 -8.54173  -7.73958  1.000 58.23067  ? 243 ASP B OD1 1 
ATOM   4128 O  OD2 . ASP B 1 244 ? -36.69719 -9.14942  -8.31894  1.000 58.49935  ? 243 ASP B OD2 1 
ATOM   4129 N  N   . HIS B 1 245 ? -39.05128 -12.37252 -4.34336  1.000 61.25069  ? 244 HIS B N   1 
ATOM   4130 C  CA  . HIS B 1 245 ? -39.24585 -13.70444 -3.77510  1.000 61.36237  ? 244 HIS B CA  1 
ATOM   4131 C  C   . HIS B 1 245 ? -39.81943 -13.54461 -2.37125  1.000 64.01746  ? 244 HIS B C   1 
ATOM   4132 O  O   . HIS B 1 245 ? -39.13188 -13.78428 -1.37053  1.000 52.40856  ? 244 HIS B O   1 
ATOM   4133 C  CB  . HIS B 1 245 ? -37.93296 -14.49016 -3.77160  1.000 56.86775  ? 244 HIS B CB  1 
ATOM   4134 C  CG  . HIS B 1 245 ? -37.43142 -14.84833 -5.13965  1.000 58.64716  ? 244 HIS B CG  1 
ATOM   4135 N  ND1 . HIS B 1 245 ? -36.68609 -13.98378 -5.91325  1.000 58.85042  ? 244 HIS B ND1 1 
ATOM   4136 C  CD2 . HIS B 1 245 ? -37.55888 -15.98409 -5.86614  1.000 58.69212  ? 244 HIS B CD2 1 
ATOM   4137 C  CE1 . HIS B 1 245 ? -36.37906 -14.56872 -7.05700  1.000 57.32676  ? 244 HIS B CE1 1 
ATOM   4138 N  NE2 . HIS B 1 245 ? -36.89609 -15.78410 -7.05325  1.000 59.46509  ? 244 HIS B NE2 1 
ATOM   4139 N  N   . PRO B 1 246 ? -41.08984 -13.13902 -2.26497  1.000 65.42467  ? 245 PRO B N   1 
ATOM   4140 C  CA  . PRO B 1 246 ? -41.63349 -12.72105 -0.95820  1.000 65.07546  ? 245 PRO B CA  1 
ATOM   4141 C  C   . PRO B 1 246 ? -41.66689 -13.80697 0.10641   1.000 63.05127  ? 245 PRO B C   1 
ATOM   4142 O  O   . PRO B 1 246 ? -41.76123 -13.47140 1.29400   1.000 62.86335  ? 245 PRO B O   1 
ATOM   4143 C  CB  . PRO B 1 246 ? -43.05266 -12.24846 -1.30522  1.000 67.25106  ? 245 PRO B CB  1 
ATOM   4144 C  CG  . PRO B 1 246 ? -43.37708 -12.91333 -2.59872  1.000 62.80155  ? 245 PRO B CG  1 
ATOM   4145 C  CD  . PRO B 1 246 ? -42.08320 -13.01063 -3.34552  1.000 64.25069  ? 245 PRO B CD  1 
ATOM   4146 N  N   . LYS B 1 247 ? -41.60873 -15.08524 -0.26445  1.000 65.08113  ? 246 LYS B N   1 
ATOM   4147 C  CA  . LYS B 1 247 ? -41.71518 -16.17623 0.69773   1.000 57.85257  ? 246 LYS B CA  1 
ATOM   4148 C  C   . LYS B 1 247 ? -40.36829 -16.78799 1.06901   1.000 56.36943  ? 246 LYS B C   1 
ATOM   4149 O  O   . LYS B 1 247 ? -40.32742 -17.70631 1.89520   1.000 52.97324  ? 246 LYS B O   1 
ATOM   4150 C  CB  . LYS B 1 247 ? -42.63454 -17.27425 0.15183   1.000 64.23175  ? 246 LYS B CB  1 
ATOM   4151 C  CG  . LYS B 1 247 ? -44.00077 -16.78793 -0.31152  1.000 68.37749  ? 246 LYS B CG  1 
ATOM   4152 C  CD  . LYS B 1 247 ? -44.85280 -17.93971 -0.83390  1.000 59.16815  ? 246 LYS B CD  1 
ATOM   4153 C  CE  . LYS B 1 247 ? -44.17656 -18.61454 -2.01374  1.000 57.86334  ? 246 LYS B CE  1 
ATOM   4154 N  NZ  . LYS B 1 247 ? -44.93993 -19.78977 -2.51715  1.000 64.89063  ? 246 LYS B NZ  1 
ATOM   4155 N  N   . ASP B 1 248 ? -39.26874 -16.30343 0.49053   1.000 54.45447  ? 247 ASP B N   1 
ATOM   4156 C  CA  . ASP B 1 248 ? -37.94130 -16.86099 0.72109   1.000 54.92501  ? 247 ASP B CA  1 
ATOM   4157 C  C   . ASP B 1 248 ? -37.11132 -15.97196 1.64261   1.000 45.93908  ? 247 ASP B C   1 
ATOM   4158 O  O   . ASP B 1 248 ? -35.90655 -15.80210 1.43846   1.000 43.77735  ? 247 ASP B O   1 
ATOM   4159 C  CB  . ASP B 1 248 ? -37.22433 -17.08349 -0.60896  1.000 47.09694  ? 247 ASP B CB  1 
ATOM   4160 C  CG  . ASP B 1 248 ? -38.12263 -17.71224 -1.65296  1.000 58.21689  ? 247 ASP B CG  1 
ATOM   4161 O  OD1 . ASP B 1 248 ? -39.10654 -18.37480 -1.26661  1.000 54.71890  ? 247 ASP B OD1 1 
ATOM   4162 O  OD2 . ASP B 1 248 ? -37.84961 -17.54291 -2.86227  1.000 61.53413  ? 247 ASP B OD2 1 
ATOM   4163 N  N   . PHE B 1 249 ? -37.75489 -15.41561 2.67138   1.000 50.58779  ? 248 PHE B N   1 
ATOM   4164 C  CA  . PHE B 1 249 ? -37.11836 -14.41229 3.51801   1.000 51.08749  ? 248 PHE B CA  1 
ATOM   4165 C  C   . PHE B 1 249 ? -35.85599 -14.94346 4.18627   1.000 47.63806  ? 248 PHE B C   1 
ATOM   4166 O  O   . PHE B 1 249 ? -34.83960 -14.24312 4.25299   1.000 45.53401  ? 248 PHE B O   1 
ATOM   4167 C  CB  . PHE B 1 249 ? -38.11314 -13.93505 4.57002   1.000 52.45751  ? 248 PHE B CB  1 
ATOM   4168 C  CG  . PHE B 1 249 ? -37.49143 -13.12430 5.66437   1.000 58.80791  ? 248 PHE B CG  1 
ATOM   4169 C  CD1 . PHE B 1 249 ? -37.04129 -11.83784 5.42038   1.000 56.07443  ? 248 PHE B CD1 1 
ATOM   4170 C  CD2 . PHE B 1 249 ? -37.35856 -13.64586 6.94073   1.000 55.72554  ? 248 PHE B CD2 1 
ATOM   4171 C  CE1 . PHE B 1 249 ? -36.46530 -11.08568 6.43174   1.000 48.21660  ? 248 PHE B CE1 1 
ATOM   4172 C  CE2 . PHE B 1 249 ? -36.78727 -12.89670 7.95328   1.000 62.07917  ? 248 PHE B CE2 1 
ATOM   4173 C  CZ  . PHE B 1 249 ? -36.34120 -11.61697 7.69891   1.000 57.98468  ? 248 PHE B CZ  1 
ATOM   4174 N  N   . TYR B 1 250 ? -35.89965 -16.17215 4.69896   1.000 53.26930  ? 249 TYR B N   1 
ATOM   4175 C  CA  . TYR B 1 250 ? -34.74697 -16.70970 5.40945   1.000 50.78621  ? 249 TYR B CA  1 
ATOM   4176 C  C   . TYR B 1 250 ? -33.62360 -17.13635 4.47400   1.000 48.97682  ? 249 TYR B C   1 
ATOM   4177 O  O   . TYR B 1 250 ? -32.52626 -17.44004 4.95035   1.000 46.02243  ? 249 TYR B O   1 
ATOM   4178 C  CB  . TYR B 1 250 ? -35.18879 -17.87343 6.29505   1.000 59.45418  ? 249 TYR B CB  1 
ATOM   4179 C  CG  . TYR B 1 250 ? -36.11375 -17.44086 7.41123   1.000 56.41829  ? 249 TYR B CG  1 
ATOM   4180 C  CD1 . TYR B 1 250 ? -35.62397 -16.75576 8.51235   1.000 54.28251  ? 249 TYR B CD1 1 
ATOM   4181 C  CD2 . TYR B 1 250 ? -37.47521 -17.70994 7.36127   1.000 54.29246  ? 249 TYR B CD2 1 
ATOM   4182 C  CE1 . TYR B 1 250 ? -36.46254 -16.35404 9.53694   1.000 56.60958  ? 249 TYR B CE1 1 
ATOM   4183 C  CE2 . TYR B 1 250 ? -38.32308 -17.31071 8.38213   1.000 57.90002  ? 249 TYR B CE2 1 
ATOM   4184 C  CZ  . TYR B 1 250 ? -37.81094 -16.63372 9.46744   1.000 59.00082  ? 249 TYR B CZ  1 
ATOM   4185 O  OH  . TYR B 1 250 ? -38.64969 -16.23418 10.48202  1.000 57.84991  ? 249 TYR B OH  1 
ATOM   4186 N  N   . HIS B 1 251 ? -33.87246 -17.16771 3.16410   1.000 46.87831  ? 250 HIS B N   1 
ATOM   4187 C  CA  . HIS B 1 251 ? -32.82400 -17.45182 2.19255   1.000 43.54342  ? 250 HIS B CA  1 
ATOM   4188 C  C   . HIS B 1 251 ? -32.07309 -16.18282 1.81435   1.000 44.10380  ? 250 HIS B C   1 
ATOM   4189 O  O   . HIS B 1 251 ? -30.83665 -16.16647 1.78538   1.000 41.81503  ? 250 HIS B O   1 
ATOM   4190 C  CB  . HIS B 1 251 ? -33.43279 -18.10497 0.95064   1.000 49.54555  ? 250 HIS B CB  1 
ATOM   4191 C  CG  . HIS B 1 251 ? -32.55146 -18.03914 -0.25671  1.000 45.07759  ? 250 HIS B CG  1 
ATOM   4192 N  ND1 . HIS B 1 251 ? -31.25483 -18.50697 -0.25756  1.000 44.33286  ? 250 HIS B ND1 1 
ATOM   4193 C  CD2 . HIS B 1 251 ? -32.77633 -17.55256 -1.49988  1.000 50.27806  ? 250 HIS B CD2 1 
ATOM   4194 C  CE1 . HIS B 1 251 ? -30.71889 -18.31331 -1.44913  1.000 46.32752  ? 250 HIS B CE1 1 
ATOM   4195 N  NE2 . HIS B 1 251 ? -31.62155 -17.73633 -2.22191  1.000 49.04314  ? 250 HIS B NE2 1 
ATOM   4196 N  N   . ILE B 1 252 ? -32.81376 -15.10911 1.52740   1.000 50.44447  ? 251 ILE B N   1 
ATOM   4197 C  CA  . ILE B 1 252 ? -32.19723 -13.83228 1.18976   1.000 46.12812  ? 251 ILE B CA  1 
ATOM   4198 C  C   . ILE B 1 252 ? -31.42457 -13.27350 2.37890   1.000 51.65384  ? 251 ILE B C   1 
ATOM   4199 O  O   . ILE B 1 252 ? -30.35149 -12.68152 2.20831   1.000 61.06425  ? 251 ILE B O   1 
ATOM   4200 C  CB  . ILE B 1 252 ? -33.28077 -12.85730 0.69358   1.000 51.25831  ? 251 ILE B CB  1 
ATOM   4201 C  CG1 . ILE B 1 252 ? -33.91629 -13.38334 -0.60181  1.000 56.85807  ? 251 ILE B CG1 1 
ATOM   4202 C  CG2 . ILE B 1 252 ? -32.70762 -11.46215 0.48617   1.000 57.79021  ? 251 ILE B CG2 1 
ATOM   4203 C  CD1 . ILE B 1 252 ? -35.42073 -13.39007 -0.60773  1.000 66.60551  ? 251 ILE B CD1 1 
ATOM   4204 N  N   . PHE B 1 253 ? -31.93324 -13.46564 3.59608   1.000 51.13753  ? 252 PHE B N   1 
ATOM   4205 C  CA  . PHE B 1 253 ? -31.26024 -13.02308 4.81795   1.000 53.47348  ? 252 PHE B CA  1 
ATOM   4206 C  C   . PHE B 1 253 ? -31.06425 -14.25240 5.70035   1.000 49.33070  ? 252 PHE B C   1 
ATOM   4207 O  O   . PHE B 1 253 ? -31.86432 -14.52093 6.60872   1.000 50.57714  ? 252 PHE B O   1 
ATOM   4208 C  CB  . PHE B 1 253 ? -32.05489 -11.91985 5.52659   1.000 51.20520  ? 252 PHE B CB  1 
ATOM   4209 C  CG  . PHE B 1 253 ? -32.47109 -10.78163 4.62058   1.000 49.57286  ? 252 PHE B CG  1 
ATOM   4210 C  CD1 . PHE B 1 253 ? -31.55613 -9.81956  4.21527   1.000 56.41288  ? 252 PHE B CD1 1 
ATOM   4211 C  CD2 . PHE B 1 253 ? -33.78073 -10.67829 4.17603   1.000 51.98961  ? 252 PHE B CD2 1 
ATOM   4212 C  CE1 . PHE B 1 253 ? -31.94008 -8.78003  3.37660   1.000 65.10314  ? 252 PHE B CE1 1 
ATOM   4213 C  CE2 . PHE B 1 253 ? -34.16932 -9.64227  3.34085   1.000 49.69433  ? 252 PHE B CE2 1 
ATOM   4214 C  CZ  . PHE B 1 253 ? -33.24865 -8.69274  2.94085   1.000 57.54160  ? 252 PHE B CZ  1 
ATOM   4215 N  N   . PRO B 1 254 ? -30.00046 -15.01867 5.45693   1.000 49.62853  ? 253 PRO B N   1 
ATOM   4216 C  CA  . PRO B 1 254 ? -29.84147 -16.32446 6.11451   1.000 42.97991  ? 253 PRO B CA  1 
ATOM   4217 C  C   . PRO B 1 254 ? -29.56516 -16.17934 7.59696   1.000 47.99583  ? 253 PRO B C   1 
ATOM   4218 O  O   . PRO B 1 254 ? -28.89366 -15.22912 8.03060   1.000 49.95874  ? 253 PRO B O   1 
ATOM   4219 C  CB  . PRO B 1 254 ? -28.64176 -16.94154 5.37962   1.000 40.42385  ? 253 PRO B CB  1 
ATOM   4220 C  CG  . PRO B 1 254 ? -27.85710 -15.76057 4.90600   1.000 46.22025  ? 253 PRO B CG  1 
ATOM   4221 C  CD  . PRO B 1 254 ? -28.88266 -14.71680 4.54572   1.000 42.10204  ? 253 PRO B CD  1 
ATOM   4222 N  N   . PRO B 1 255 ? -30.05344 -17.11304 8.40925   1.000 50.15542  ? 254 PRO B N   1 
ATOM   4223 C  CA  . PRO B 1 255 ? -29.90909 -17.00986 9.86221   1.000 55.16362  ? 254 PRO B CA  1 
ATOM   4224 C  C   . PRO B 1 255 ? -28.61496 -17.61837 10.38292  1.000 51.36830  ? 254 PRO B C   1 
ATOM   4225 O  O   . PRO B 1 255 ? -28.02332 -18.51005 9.77555   1.000 53.88985  ? 254 PRO B O   1 
ATOM   4226 C  CB  . PRO B 1 255 ? -31.12478 -17.79571 10.37520  1.000 50.97073  ? 254 PRO B CB  1 
ATOM   4227 C  CG  . PRO B 1 255 ? -31.32642 -18.85217 9.33359   1.000 54.06468  ? 254 PRO B CG  1 
ATOM   4228 C  CD  . PRO B 1 255 ? -30.93558 -18.22751 8.01562   1.000 52.87498  ? 254 PRO B CD  1 
ATOM   4229 N  N   . GLN B 1 256 ? -28.19359 -17.11186 11.54276  1.000 52.21991  ? 255 GLN B N   1 
ATOM   4230 C  CA  . GLN B 1 256 ? -27.06034 -17.66120 12.29012  1.000 70.16172  ? 255 GLN B CA  1 
ATOM   4231 C  C   . GLN B 1 256 ? -27.42235 -17.54335 13.76901  1.000 67.81033  ? 255 GLN B C   1 
ATOM   4232 O  O   . GLN B 1 256 ? -27.14164 -16.52565 14.40617  1.000 68.66472  ? 255 GLN B O   1 
ATOM   4233 C  CB  . GLN B 1 256 ? -25.77381 -16.92303 11.94814  1.000 57.27088  ? 255 GLN B CB  1 
ATOM   4234 C  CG  . GLN B 1 256 ? -24.53924 -17.43243 12.64615  1.000 78.20956  ? 255 GLN B CG  1 
ATOM   4235 C  CD  . GLN B 1 256 ? -23.34190 -16.56160 12.34886  1.000 79.19240  ? 255 GLN B CD  1 
ATOM   4236 O  OE1 . GLN B 1 256 ? -23.41669 -15.64228 11.53392  1.000 90.60139  ? 255 GLN B OE1 1 
ATOM   4237 N  NE2 . GLN B 1 256 ? -22.22982 -16.84106 13.00981  1.000 86.37199  ? 255 GLN B NE2 1 
ATOM   4238 N  N   . SER B 1 257 ? -28.04149 -18.58831 14.30887  1.000 70.15644  ? 256 SER B N   1 
ATOM   4239 C  CA  . SER B 1 257 ? -28.60657 -18.49981 15.64676  1.000 76.00229  ? 256 SER B CA  1 
ATOM   4240 C  C   . SER B 1 257 ? -27.54052 -18.74426 16.71625  1.000 81.37965  ? 256 SER B C   1 
ATOM   4241 O  O   . SER B 1 257 ? -26.51122 -19.38416 16.47864  1.000 79.11457  ? 256 SER B O   1 
ATOM   4242 C  CB  . SER B 1 257 ? -29.76035 -19.49053 15.80352  1.000 69.51139  ? 256 SER B CB  1 
ATOM   4243 O  OG  . SER B 1 257 ? -29.54256 -20.65525 15.02565  1.000 73.37314  ? 256 SER B OG  1 
ATOM   4244 N  N   . GLY B 1 258 ? -27.80246 -18.22062 17.91299  1.000 89.80205  ? 257 GLY B N   1 
ATOM   4245 C  CA  . GLY B 1 258 ? -26.85635 -18.34401 19.00146  1.000 87.65392  ? 257 GLY B CA  1 
ATOM   4246 C  C   . GLY B 1 258 ? -26.94642 -17.24984 20.04385  1.000 92.27597  ? 257 GLY B C   1 
ATOM   4247 O  O   . GLY B 1 258 ? -28.03511 -16.94263 20.53972  1.000 93.64423  ? 257 GLY B O   1 
ATOM   4248 N  N   . TYR B 1 259 ? -25.80072 -16.66921 20.40789  1.000 90.31337  ? 258 TYR B N   1 
ATOM   4249 C  CA  . TYR B 1 259 ? -25.78794 -15.72018 21.51581  1.000 92.31154  ? 258 TYR B CA  1 
ATOM   4250 C  C   . TYR B 1 259 ? -26.42230 -14.38516 21.14417  1.000 91.33703  ? 258 TYR B C   1 
ATOM   4251 O  O   . TYR B 1 259 ? -27.04484 -13.74251 21.99803  1.000 92.71850  ? 258 TYR B O   1 
ATOM   4252 C  CB  . TYR B 1 259 ? -24.36201 -15.50591 22.01923  1.000 89.87824  ? 258 TYR B CB  1 
ATOM   4253 C  CG  . TYR B 1 259 ? -24.24460 -14.33251 22.96554  1.000 87.01637  ? 258 TYR B CG  1 
ATOM   4254 C  CD1 . TYR B 1 259 ? -24.94541 -14.30477 24.16073  1.000 90.83623  ? 258 TYR B CD1 1 
ATOM   4255 C  CD2 . TYR B 1 259 ? -23.44371 -13.24762 22.65746  1.000 83.85720  ? 258 TYR B CD2 1 
ATOM   4256 C  CE1 . TYR B 1 259 ? -24.85132 -13.22214 25.02222  1.000 92.36111  ? 258 TYR B CE1 1 
ATOM   4257 C  CE2 . TYR B 1 259 ? -23.33644 -12.16672 23.51450  1.000 85.07320  ? 258 TYR B CE2 1 
ATOM   4258 C  CZ  . TYR B 1 259 ? -24.04010 -12.15832 24.69594  1.000 94.62761  ? 258 TYR B CZ  1 
ATOM   4259 O  OH  . TYR B 1 259 ? -23.93187 -11.08077 25.54849  1.000 98.26655  ? 258 TYR B OH  1 
ATOM   4260 N  N   . VAL B 1 260 ? -26.28692 -13.95222 19.88751  1.000 91.06551  ? 259 VAL B N   1 
ATOM   4261 C  CA  . VAL B 1 260 ? -26.84402 -12.66478 19.49119  1.000 93.24406  ? 259 VAL B CA  1 
ATOM   4262 C  C   . VAL B 1 260 ? -28.35825 -12.66651 19.65626  1.000 95.73209  ? 259 VAL B C   1 
ATOM   4263 O  O   . VAL B 1 260 ? -28.96057 -11.60970 19.89299  1.000 95.69553  ? 259 VAL B O   1 
ATOM   4264 C  CB  . VAL B 1 260 ? -26.42586 -12.31815 18.04157  1.000 92.47788  ? 259 VAL B CB  1 
ATOM   4265 C  CG1 . VAL B 1 260 ? -26.99266 -13.32282 17.05584  1.000 95.67110  ? 259 VAL B CG1 1 
ATOM   4266 C  CG2 . VAL B 1 260 ? -26.83302 -10.89229 17.68120  1.000 79.03822  ? 259 VAL B CG2 1 
ATOM   4267 N  N   . CYS B 1 261 ? -28.98468 -13.85059 19.60277  1.000 99.21100  ? 260 CYS B N   1 
ATOM   4268 C  CA  . CYS B 1 261 ? -30.41783 -13.98512 19.84243  1.000 100.06274 ? 260 CYS B CA  1 
ATOM   4269 C  C   . CYS B 1 261 ? -30.83271 -13.45190 21.20323  1.000 97.96772  ? 260 CYS B C   1 
ATOM   4270 O  O   . CYS B 1 261 ? -32.02395 -13.20403 21.41114  1.000 94.53152  ? 260 CYS B O   1 
ATOM   4271 C  CB  . CYS B 1 261 ? -30.84838 -15.45365 19.73620  1.000 101.91319 ? 260 CYS B CB  1 
ATOM   4272 S  SG  . CYS B 1 261 ? -30.49466 -16.25184 18.13524  1.000 176.22319 ? 260 CYS B SG  1 
ATOM   4273 N  N   . ARG B 1 262 ? -29.89454 -13.28027 22.13486  1.000 95.81451  ? 261 ARG B N   1 
ATOM   4274 C  CA  . ARG B 1 262 ? -30.25144 -12.70217 23.42169  1.000 97.06382  ? 261 ARG B CA  1 
ATOM   4275 C  C   . ARG B 1 262 ? -30.55002 -11.22045 23.28184  1.000 94.79035  ? 261 ARG B C   1 
ATOM   4276 O  O   . ARG B 1 262 ? -31.53074 -10.72684 23.84693  1.000 92.24492  ? 261 ARG B O   1 
ATOM   4277 C  CB  . ARG B 1 262 ? -29.13869 -12.92776 24.44470  1.000 98.64319  ? 261 ARG B CB  1 
ATOM   4278 C  CG  . ARG B 1 262 ? -29.28903 -14.18447 25.28259  1.000 100.77319 ? 261 ARG B CG  1 
ATOM   4279 C  CD  . ARG B 1 262 ? -28.87411 -15.41221 24.49579  1.000 99.82387  ? 261 ARG B CD  1 
ATOM   4280 N  NE  . ARG B 1 262 ? -28.00395 -16.28810 25.27085  1.000 98.28027  ? 261 ARG B NE  1 
ATOM   4281 C  CZ  . ARG B 1 262 ? -27.37307 -17.34034 24.76642  1.000 94.98407  ? 261 ARG B CZ  1 
ATOM   4282 N  NH1 . ARG B 1 262 ? -27.49661 -17.67446 23.49112  1.000 91.72042  ? 261 ARG B NH1 1 
ATOM   4283 N  NH2 . ARG B 1 262 ? -26.59315 -18.07231 25.55742  1.000 89.92802  ? 261 ARG B NH2 1 
ATOM   4284 N  N   . TYR B 1 263 ? -29.70527 -10.49459 22.54863  1.000 93.81919  ? 262 TYR B N   1 
ATOM   4285 C  CA  . TYR B 1 263 ? -29.95242 -9.07821  22.31924  1.000 93.76283  ? 262 TYR B CA  1 
ATOM   4286 C  C   . TYR B 1 263 ? -30.79366 -8.83401  21.08095  1.000 95.69879  ? 262 TYR B C   1 
ATOM   4287 O  O   . TYR B 1 263 ? -31.11028 -7.67787  20.78248  1.000 97.12643  ? 262 TYR B O   1 
ATOM   4288 C  CB  . TYR B 1 263 ? -28.63098 -8.31020  22.20405  1.000 91.30353  ? 262 TYR B CB  1 
ATOM   4289 N  N   . CYS B 1 264 ? -31.14874 -9.88169  20.36052  1.000 103.27251 ? 263 CYS B N   1 
ATOM   4290 C  CA  . CYS B 1 264 ? -31.97291 -9.72887  19.17709  1.000 90.73586  ? 263 CYS B CA  1 
ATOM   4291 C  C   . CYS B 1 264 ? -33.41574 -9.49856  19.59599  1.000 82.31492  ? 263 CYS B C   1 
ATOM   4292 O  O   . CYS B 1 264 ? -34.00126 -10.35790 20.26811  1.000 82.40145  ? 263 CYS B O   1 
ATOM   4293 C  CB  . CYS B 1 264 ? -31.86518 -10.95840 18.28534  1.000 92.49319  ? 263 CYS B CB  1 
ATOM   4294 S  SG  . CYS B 1 264 ? -32.86225 -10.83024 16.78906  1.000 163.78319 ? 263 CYS B SG  1 
ATOM   4295 N  N   . PRO B 1 265 ? -34.02810 -8.36940  19.22783  1.000 72.40174  ? 264 PRO B N   1 
ATOM   4296 C  CA  . PRO B 1 265 ? -35.41034 -8.10503  19.64718  1.000 70.46412  ? 264 PRO B CA  1 
ATOM   4297 C  C   . PRO B 1 265 ? -36.46058 -8.89190  18.88030  1.000 71.58061  ? 264 PRO B C   1 
ATOM   4298 O  O   . PRO B 1 265 ? -37.65381 -8.70137  19.14543  1.000 62.35162  ? 264 PRO B O   1 
ATOM   4299 C  CB  . PRO B 1 265 ? -35.56563 -6.60219  19.38616  1.000 72.86481  ? 264 PRO B CB  1 
ATOM   4300 C  CG  . PRO B 1 265 ? -34.62865 -6.32643  18.26693  1.000 67.88319  ? 264 PRO B CG  1 
ATOM   4301 C  CD  . PRO B 1 265 ? -33.45947 -7.25633  18.44579  1.000 72.97262  ? 264 PRO B CD  1 
ATOM   4302 N  N   . PHE B 1 266 ? -36.06949 -9.76351  17.94663  1.000 73.76336  ? 265 PHE B N   1 
ATOM   4303 C  CA  . PHE B 1 266 ? -37.01104 -10.47795 17.09242  1.000 72.06441  ? 265 PHE B CA  1 
ATOM   4304 C  C   . PHE B 1 266 ? -37.06156 -11.96875 17.40213  1.000 71.12541  ? 265 PHE B C   1 
ATOM   4305 O  O   . PHE B 1 266 ? -37.51468 -12.75498 16.56539  1.000 80.01319  ? 265 PHE B O   1 
ATOM   4306 C  CB  . PHE B 1 266 ? -36.65880 -10.26278 15.62086  1.000 72.36126  ? 265 PHE B CB  1 
ATOM   4307 C  CG  . PHE B 1 266 ? -36.43111 -8.82651  15.25859  1.000 67.14875  ? 265 PHE B CG  1 
ATOM   4308 C  CD1 . PHE B 1 266 ? -37.49581 -7.94951  15.14440  1.000 64.99444  ? 265 PHE B CD1 1 
ATOM   4309 C  CD2 . PHE B 1 266 ? -35.15060 -8.35060  15.03634  1.000 68.53841  ? 265 PHE B CD2 1 
ATOM   4310 C  CE1 . PHE B 1 266 ? -37.28739 -6.62336  14.81462  1.000 67.19184  ? 265 PHE B CE1 1 
ATOM   4311 C  CE2 . PHE B 1 266 ? -34.93585 -7.02700  14.70602  1.000 66.57496  ? 265 PHE B CE2 1 
ATOM   4312 C  CZ  . PHE B 1 266 ? -36.00556 -6.16233  14.59428  1.000 66.38933  ? 265 PHE B CZ  1 
ATOM   4313 N  N   . THR B 1 267 ? -36.61119 -12.36630 18.59482  1.000 75.82387  ? 266 THR B N   1 
ATOM   4314 C  CA  . THR B 1 267 ? -36.50791 -13.78348 18.93436  1.000 77.78280  ? 266 THR B CA  1 
ATOM   4315 C  C   . THR B 1 267 ? -37.85287 -14.49436 18.79906  1.000 73.10684  ? 266 THR B C   1 
ATOM   4316 O  O   . THR B 1 267 ? -37.90867 -15.65595 18.37807  1.000 75.46448  ? 266 THR B O   1 
ATOM   4317 C  CB  . THR B 1 267 ? -35.94536 -13.93307 20.35327  1.000 71.92817  ? 266 THR B CB  1 
ATOM   4318 O  OG1 . THR B 1 267 ? -34.62967 -13.36743 20.40516  1.000 79.96681  ? 266 THR B OG1 1 
ATOM   4319 C  CG2 . THR B 1 267 ? -35.86476 -15.39349 20.75809  1.000 77.16870  ? 266 THR B CG2 1 
ATOM   4320 N  N   . SER B 1 268 ? -38.95117 -13.80518 19.12301  1.000 76.46678  ? 267 SER B N   1 
ATOM   4321 C  CA  . SER B 1 268 ? -40.26467 -14.44520 19.08070  1.000 71.64867  ? 267 SER B CA  1 
ATOM   4322 C  C   . SER B 1 268 ? -40.73796 -14.66098 17.64797  1.000 67.18402  ? 267 SER B C   1 
ATOM   4323 O  O   . SER B 1 268 ? -41.36328 -15.68372 17.34564  1.000 82.47138  ? 267 SER B O   1 
ATOM   4324 C  CB  . SER B 1 268 ? -41.28486 -13.61625 19.86501  1.000 77.56463  ? 267 SER B CB  1 
ATOM   4325 O  OG  . SER B 1 268 ? -41.28385 -12.26764 19.43122  1.000 70.88319  ? 267 SER B OG  1 
ATOM   4326 N  N   . ILE B 1 269 ? -40.43899 -13.71692 16.74711  1.000 70.83488  ? 268 ILE B N   1 
ATOM   4327 C  CA  . ILE B 1 269 ? -40.92160 -13.79514 15.37043  1.000 69.48929  ? 268 ILE B CA  1 
ATOM   4328 C  C   . ILE B 1 269 ? -39.94050 -14.48792 14.43117  1.000 60.84237  ? 268 ILE B C   1 
ATOM   4329 O  O   . ILE B 1 269 ? -40.26998 -14.69824 13.25650  1.000 66.94851  ? 268 ILE B O   1 
ATOM   4330 C  CB  . ILE B 1 269 ? -41.25622 -12.39171 14.82111  1.000 60.92191  ? 268 ILE B CB  1 
ATOM   4331 C  CG1 . ILE B 1 269 ? -40.04098 -11.47123 14.93278  1.000 64.01383  ? 268 ILE B CG1 1 
ATOM   4332 C  CG2 . ILE B 1 269 ? -42.45327 -11.80084 15.55061  1.000 59.83319  ? 268 ILE B CG2 1 
ATOM   4333 C  CD1 . ILE B 1 269 ? -40.29421 -10.05405 14.45970  1.000 67.65161  ? 268 ILE B CD1 1 
ATOM   4334 N  N   . CYS B 1 270 ? -38.75095 -14.85178 14.90356  1.000 59.24449  ? 269 CYS B N   1 
ATOM   4335 C  CA  . CYS B 1 270 ? -37.78733 -15.58603 14.09087  1.000 64.09330  ? 269 CYS B CA  1 
ATOM   4336 C  C   . CYS B 1 270 ? -38.02182 -17.08477 14.24934  1.000 73.71555  ? 269 CYS B C   1 
ATOM   4337 O  O   . CYS B 1 270 ? -38.10494 -17.59430 15.37340  1.000 71.94288  ? 269 CYS B O   1 
ATOM   4338 C  CB  . CYS B 1 270 ? -36.35078 -15.23099 14.48658  1.000 61.01319  ? 269 CYS B CB  1 
ATOM   4339 S  SG  . CYS B 1 270 ? -35.05480 -16.14733 13.58329  1.000 98.00319  ? 269 CYS B SG  1 
ATOM   4340 N  N   . ASP B 1 271 ? -38.12065 -17.79004 13.12185  1.000 66.64524  ? 270 ASP B N   1 
ATOM   4341 C  CA  . ASP B 1 271 ? -38.36664 -19.22667 13.15724  1.000 67.94769  ? 270 ASP B CA  1 
ATOM   4342 C  C   . ASP B 1 271 ? -37.11871 -20.04271 13.46869  1.000 66.06343  ? 270 ASP B C   1 
ATOM   4343 O  O   . ASP B 1 271 ? -37.23501 -21.24481 13.73956  1.000 71.42855  ? 270 ASP B O   1 
ATOM   4344 C  CB  . ASP B 1 271 ? -38.95692 -19.69130 11.82499  1.000 66.65254  ? 270 ASP B CB  1 
ATOM   4345 C  CG  . ASP B 1 271 ? -40.29169 -19.04253 11.52384  1.000 67.54624  ? 270 ASP B CG  1 
ATOM   4346 O  OD1 . ASP B 1 271 ? -40.76325 -18.24065 12.35848  1.000 80.40408  ? 270 ASP B OD1 1 
ATOM   4347 O  OD2 . ASP B 1 271 ? -40.86997 -19.33169 10.45488  1.000 61.49415  ? 270 ASP B OD2 1 
ATOM   4348 N  N   . TYR B 1 272 ? -35.93921 -19.42582 13.44458  1.000 59.52116  ? 271 TYR B N   1 
ATOM   4349 C  CA  . TYR B 1 272 ? -34.68162 -20.12989 13.65111  1.000 62.41700  ? 271 TYR B CA  1 
ATOM   4350 C  C   . TYR B 1 272 ? -34.01175 -19.74422 14.96318  1.000 68.37390  ? 271 TYR B C   1 
ATOM   4351 O  O   . TYR B 1 272 ? -32.86108 -20.12774 15.19588  1.000 64.34614  ? 271 TYR B O   1 
ATOM   4352 C  CB  . TYR B 1 272 ? -33.72628 -19.86333 12.48487  1.000 53.32593  ? 271 TYR B CB  1 
ATOM   4353 C  CG  . TYR B 1 272 ? -34.15276 -20.45879 11.15491  1.000 67.13957  ? 271 TYR B CG  1 
ATOM   4354 C  CD1 . TYR B 1 272 ? -35.25513 -19.96534 10.46752  1.000 56.63480  ? 271 TYR B CD1 1 
ATOM   4355 C  CD2 . TYR B 1 272 ? -33.43203 -21.49274 10.57329  1.000 58.77991  ? 271 TYR B CD2 1 
ATOM   4356 C  CE1 . TYR B 1 272 ? -35.64192 -20.50054 9.25464   1.000 62.44934  ? 271 TYR B CE1 1 
ATOM   4357 C  CE2 . TYR B 1 272 ? -33.80842 -22.03054 9.35887   1.000 59.00420  ? 271 TYR B CE2 1 
ATOM   4358 C  CZ  . TYR B 1 272 ? -34.91225 -21.53376 8.70413   1.000 60.64363  ? 271 TYR B CZ  1 
ATOM   4359 O  OH  . TYR B 1 272 ? -35.27402 -22.07707 7.49437   1.000 54.68944  ? 271 TYR B OH  1 
ATOM   4360 N  N   . ALA B 1 273 ? -34.71021 -19.01669 15.83079  1.000 61.89741  ? 272 ALA B N   1 
ATOM   4361 C  CA  . ALA B 1 273 ? -34.09401 -18.41979 17.00725  1.000 78.27873  ? 272 ALA B CA  1 
ATOM   4362 C  C   . ALA B 1 273 ? -33.56848 -19.47988 17.96848  1.000 79.94714  ? 272 ALA B C   1 
ATOM   4363 O  O   . ALA B 1 273 ? -34.08134 -20.60003 18.03605  1.000 69.04927  ? 272 ALA B O   1 
ATOM   4364 C  CB  . ALA B 1 273 ? -35.10296 -17.53088 17.72928  1.000 72.47077  ? 272 ALA B CB  1 
ATOM   4365 N  N   . ASN B 1 274 ? -32.52812 -19.10919 18.71795  1.000 88.74933  ? 273 ASN B N   1 
ATOM   4366 C  CA  . ASN B 1 274 ? -31.97832 -19.97849 19.75494  1.000 92.94684  ? 273 ASN B CA  1 
ATOM   4367 C  C   . ASN B 1 274 ? -33.00941 -20.13352 20.86253  1.000 92.47341  ? 273 ASN B C   1 
ATOM   4368 O  O   . ASN B 1 274 ? -33.23570 -19.20454 21.64508  1.000 86.57788  ? 273 ASN B O   1 
ATOM   4369 C  CB  . ASN B 1 274 ? -30.67422 -19.41033 20.31027  1.000 89.83114  ? 273 ASN B CB  1 
ATOM   4370 C  CG  . ASN B 1 274 ? -30.07051 -20.28752 21.39018  1.000 92.23374  ? 273 ASN B CG  1 
ATOM   4371 O  OD1 . ASN B 1 274 ? -29.92943 -21.49964 21.21525  1.000 97.21254  ? 273 ASN B OD1 1 
ATOM   4372 N  ND2 . ASN B 1 274 ? -29.71984 -19.68011 22.51883  1.000 88.73587  ? 273 ASN B ND2 1 
ATOM   4373 N  N   . LYS B 1 275 ? -33.64170 -21.30331 20.92550  1.000 92.20960  ? 274 LYS B N   1 
ATOM   4374 C  CA  . LYS B 1 275 ? -34.64819 -21.58140 21.93792  1.000 94.91084  ? 274 LYS B CA  1 
ATOM   4375 C  C   . LYS B 1 275 ? -34.10071 -22.36191 23.12630  1.000 96.72697  ? 274 LYS B C   1 
ATOM   4376 O  O   . LYS B 1 275 ? -34.79761 -22.49059 24.13932  1.000 91.37968  ? 274 LYS B O   1 
ATOM   4377 C  CB  . LYS B 1 275 ? -35.82064 -22.33848 21.31324  1.000 95.44435  ? 274 LYS B CB  1 
ATOM   4378 C  CG  . LYS B 1 275 ? -35.47012 -23.02988 20.00742  1.000 94.77576  ? 274 LYS B CG  1 
ATOM   4379 C  CD  . LYS B 1 275 ? -36.70992 -23.55809 19.31432  1.000 97.71045  ? 274 LYS B CD  1 
ATOM   4380 C  CE  . LYS B 1 275 ? -36.35486 -24.50130 18.17981  1.000 97.06974  ? 274 LYS B CE  1 
ATOM   4381 N  NZ  . LYS B 1 275 ? -35.73841 -23.79449 17.02797  1.000 92.46759  ? 274 LYS B NZ  1 
ATOM   4382 N  N   . GLU B 1 276 ? -32.87575 -22.86639 23.03491  1.000 102.82434 ? 275 GLU B N   1 
ATOM   4383 C  CA  . GLU B 1 276 ? -32.22654 -23.53335 24.15203  1.000 94.56035  ? 275 GLU B CA  1 
ATOM   4384 C  C   . GLU B 1 276 ? -32.05832 -22.58520 25.34015  1.000 87.67150  ? 275 GLU B C   1 
ATOM   4385 O  O   . GLU B 1 276 ? -32.21699 -22.97975 26.49064  1.000 83.04156  ? 275 GLU B O   1 
ATOM   4386 C  CB  . GLU B 1 276 ? -30.86677 -24.08457 23.70799  1.000 90.75583  ? 275 GLU B CB  1 
ATOM   4387 C  CG  . GLU B 1 276 ? -30.89814 -25.51250 23.18207  1.000 94.61988  ? 275 GLU B CG  1 
ATOM   4388 C  CD  . GLU B 1 276 ? -31.39674 -25.61293 21.74467  1.000 95.64418  ? 275 GLU B CD  1 
ATOM   4389 O  OE1 . GLU B 1 276 ? -31.67966 -24.56044 21.12610  1.000 106.86103 ? 275 GLU B OE1 1 
ATOM   4390 O  OE2 . GLU B 1 276 ? -31.49937 -26.74234 21.21282  1.000 86.94003  ? 275 GLU B OE2 1 
HETATM 4391 FE FE1 . SF4 C 2 .   ? 4.93584   -15.13356 10.50225  1.000 76.20319  ? 301 SF4 A FE1 1 
HETATM 4392 FE FE2 . SF4 C 2 .   ? 7.40803   -14.09737 9.98354   1.000 81.01482  ? 301 SF4 A FE2 1 
HETATM 4393 FE FE3 . SF4 C 2 .   ? 6.96266   -15.47632 12.30424  1.000 80.00319  ? 301 SF4 A FE3 1 
HETATM 4394 FE FE4 . SF4 C 2 .   ? 5.85465   -13.00574 11.94699  1.000 58.54027  ? 301 SF4 A FE4 1 
HETATM 4395 S  S1  . SF4 C 2 .   ? 8.08621   -13.49352 12.07804  1.000 56.68607  ? 301 SF4 A S1  1 
HETATM 4396 S  S2  . SF4 C 2 .   ? 4.80770   -14.86562 12.76837  1.000 74.47319  ? 301 SF4 A S2  1 
HETATM 4397 S  S3  . SF4 C 2 .   ? 5.40373   -13.04040 9.70873   1.000 62.52387  ? 301 SF4 A S3  1 
HETATM 4398 S  S4  . SF4 C 2 .   ? 6.86310   -16.31089 10.17634  1.000 55.44319  ? 301 SF4 A S4  1 
HETATM 4399 MG MG  . MG  D 3 .   ? 14.18812  8.20459   18.57814  1.000 70.53224  ? 302 MG  A MG  1 
HETATM 4400 C  C1  . EDO E 4 .   ? 15.20681  25.58429  18.86701  1.000 67.56667  ? 303 EDO A C1  1 
HETATM 4401 O  O1  . EDO E 4 .   ? 15.20478  25.02873  17.54493  1.000 68.36223  ? 303 EDO A O1  1 
HETATM 4402 C  C2  . EDO E 4 .   ? 14.83451  24.49000  19.86292  1.000 64.86262  ? 303 EDO A C2  1 
HETATM 4403 O  O2  . EDO E 4 .   ? 14.45074  25.09174  21.10475  1.000 67.81308  ? 303 EDO A O2  1 
HETATM 4404 C  C1  . EDO F 4 .   ? 6.63895   -13.35254 24.37770  1.000 82.05778  ? 304 EDO A C1  1 
HETATM 4405 O  O1  . EDO F 4 .   ? 5.25182   -13.70662 24.40224  1.000 83.04938  ? 304 EDO A O1  1 
HETATM 4406 C  C2  . EDO F 4 .   ? 6.83931   -12.00974 23.68479  1.000 82.57767  ? 304 EDO A C2  1 
HETATM 4407 O  O2  . EDO F 4 .   ? 6.46221   -10.95962 24.58516  1.000 90.51120  ? 304 EDO A O2  1 
HETATM 4408 C  C1  . EDO G 4 .   ? 9.03785   4.85937   3.39791   1.000 74.67500  ? 305 EDO A C1  1 
HETATM 4409 O  O1  . EDO G 4 .   ? 9.34585   3.86310   2.41778   1.000 54.76135  ? 305 EDO A O1  1 
HETATM 4410 C  C2  . EDO G 4 .   ? 8.37335   6.04477   2.71471   1.000 82.85759  ? 305 EDO A C2  1 
HETATM 4411 O  O2  . EDO G 4 .   ? 6.96526   6.04769   2.98187   1.000 65.08263  ? 305 EDO A O2  1 
HETATM 4412 FE FE1 . SF4 H 2 .   ? -31.26194 -15.11113 16.36776  1.000 88.68319  ? 301 SF4 B FE1 1 
HETATM 4413 FE FE2 . SF4 H 2 .   ? -33.38939 -15.06637 14.64555  1.000 84.49319  ? 301 SF4 B FE2 1 
HETATM 4414 FE FE3 . SF4 H 2 .   ? -32.57076 -12.76666 15.87952  1.000 89.55319  ? 301 SF4 B FE3 1 
HETATM 4415 FE FE4 . SF4 H 2 .   ? -31.02597 -13.89606 13.93596  1.000 91.53319  ? 301 SF4 B FE4 1 
HETATM 4416 S  S1  . SF4 H 2 .   ? -33.11300 -13.01526 13.67124  1.000 67.12892  ? 301 SF4 B S1  1 
HETATM 4417 S  S2  . SF4 H 2 .   ? -30.31224 -13.07985 15.95318  1.000 81.61319  ? 301 SF4 B S2  1 
HETATM 4418 S  S3  . SF4 H 2 .   ? -31.39210 -16.11803 14.31233  1.000 61.16319  ? 301 SF4 B S3  1 
HETATM 4419 S  S4  . SF4 H 2 .   ? -33.42912 -14.62245 16.89387  1.000 80.77319  ? 301 SF4 B S4  1 
HETATM 4420 C  C1  . EDO I 4 .   ? -25.01335 26.42684  25.20744  1.000 81.14950  ? 302 EDO B C1  1 
HETATM 4421 O  O1  . EDO I 4 .   ? -25.77873 25.75508  26.21203  1.000 78.50802  ? 302 EDO B O1  1 
HETATM 4422 C  C2  . EDO I 4 .   ? -23.89171 25.50684  24.73827  1.000 83.10667  ? 302 EDO B C2  1 
HETATM 4423 O  O2  . EDO I 4 .   ? -24.44195 24.41325  23.99347  1.000 68.81602  ? 302 EDO B O2  1 
HETATM 4424 MG MG  . MG  J 3 .   ? -23.35289 7.32340   20.85392  1.000 76.86312  ? 303 MG  B MG  1 
HETATM 4425 C  C1  . EDO K 4 .   ? -17.54003 -2.90569  18.19183  1.000 75.83920  ? 304 EDO B C1  1 
HETATM 4426 O  O1  . EDO K 4 .   ? -16.31334 -3.45816  17.70065  1.000 71.98480  ? 304 EDO B O1  1 
HETATM 4427 C  C2  . EDO K 4 .   ? -18.69389 -3.28720  17.27067  1.000 68.89028  ? 304 EDO B C2  1 
HETATM 4428 O  O2  . EDO K 4 .   ? -19.12094 -4.62295  17.56098  1.000 86.56319  ? 304 EDO B O2  1 
HETATM 4429 C  C1  . EDO L 4 .   ? -12.36677 14.22999  24.99105  1.000 70.90851  ? 305 EDO B C1  1 
HETATM 4430 O  O1  . EDO L 4 .   ? -11.71700 13.13740  25.64969  1.000 68.37764  ? 305 EDO B O1  1 
HETATM 4431 C  C2  . EDO L 4 .   ? -11.58601 14.59472  23.73360  1.000 72.80232  ? 305 EDO B C2  1 
HETATM 4432 O  O2  . EDO L 4 .   ? -10.35391 15.23125  24.09190  1.000 74.55092  ? 305 EDO B O2  1 
HETATM 4433 O  O   . HOH M 5 .   ? 12.18111  24.84916  21.72612  1.000 61.71728  ? 401 HOH A O   1 
HETATM 4434 O  O   . HOH M 5 .   ? 12.96941  4.53298   8.64166   1.000 56.18146  ? 402 HOH A O   1 
HETATM 4435 O  O   . HOH M 5 .   ? 0.41412   -20.60629 -3.69198  1.000 49.38219  ? 403 HOH A O   1 
HETATM 4436 O  O   . HOH M 5 .   ? 15.06717  7.01411   16.97088  1.000 73.39760  ? 404 HOH A O   1 
HETATM 4437 O  O   . HOH M 5 .   ? 7.47071   2.02926   2.31449   1.000 50.57656  ? 405 HOH A O   1 
HETATM 4438 O  O   . HOH M 5 .   ? 20.37565  12.19945  -12.42071 1.000 73.01032  ? 406 HOH A O   1 
HETATM 4439 O  O   . HOH M 5 .   ? 8.581     -20.787   26.328    1.000 80.63942  ? 407 HOH A O   1 
HETATM 4440 O  O   . HOH M 5 .   ? 11.03893  25.26636  44.68307  1.000 69.22607  ? 408 HOH A O   1 
HETATM 4441 O  O   . HOH M 5 .   ? 25.60776  9.52218   32.68824  1.000 61.67148  ? 409 HOH A O   1 
HETATM 4442 O  O   . HOH M 5 .   ? 11.75581  12.95152  4.33234   1.000 65.94979  ? 410 HOH A O   1 
HETATM 4443 O  O   . HOH M 5 .   ? 13.86889  7.80943   9.73007   1.000 54.89052  ? 411 HOH A O   1 
HETATM 4444 O  O   . HOH M 5 .   ? 12.50110  -15.03874 5.37768   1.000 54.79264  ? 412 HOH A O   1 
HETATM 4445 O  O   . HOH M 5 .   ? 13.53799  -9.03455  2.97808   1.000 59.96139  ? 413 HOH A O   1 
HETATM 4446 O  O   . HOH M 5 .   ? 12.55689  19.27892  44.25180  1.000 66.60134  ? 414 HOH A O   1 
HETATM 4447 O  O   . HOH M 5 .   ? 9.357     -19.562   -2.020    1.000 36.07783  ? 415 HOH A O   1 
HETATM 4448 O  O   . HOH M 5 .   ? 5.28479   0.11617   0.03939   1.000 55.02123  ? 416 HOH A O   1 
HETATM 4449 O  O   . HOH M 5 .   ? 12.59909  22.66612  18.40583  1.000 66.39359  ? 417 HOH A O   1 
HETATM 4450 O  O   . HOH M 5 .   ? 14.12507  14.26245  5.05542   1.000 67.07339  ? 418 HOH A O   1 
HETATM 4451 O  O   . HOH M 5 .   ? 5.17294   1.12816   -2.58653  1.000 57.26970  ? 419 HOH A O   1 
HETATM 4452 O  O   . HOH M 5 .   ? 10.42828  -6.18686  9.17335   1.000 59.32631  ? 420 HOH A O   1 
HETATM 4453 O  O   . HOH M 5 .   ? 34.37194  8.19836   6.89286   1.000 59.04335  ? 421 HOH A O   1 
HETATM 4454 O  O   . HOH M 5 .   ? 6.01997   -24.07804 12.96423  1.000 63.18226  ? 422 HOH A O   1 
HETATM 4455 O  O   . HOH M 5 .   ? -0.13131  16.10941  25.73817  1.000 78.49617  ? 423 HOH A O   1 
HETATM 4456 O  O   . HOH M 5 .   ? 11.81570  -21.83168 6.18787   1.000 68.25658  ? 424 HOH A O   1 
HETATM 4457 O  O   . HOH M 5 .   ? 4.10051   4.19066   -1.99051  1.000 56.76078  ? 425 HOH A O   1 
HETATM 4458 O  O   . HOH M 5 .   ? 11.41350  8.95316   18.77946  1.000 70.21311  ? 426 HOH A O   1 
HETATM 4459 O  O   . HOH M 5 .   ? 23.72984  1.85972   23.27164  1.000 57.82151  ? 427 HOH A O   1 
HETATM 4460 O  O   . HOH M 5 .   ? 25.65233  13.90772  21.97678  1.000 57.08676  ? 428 HOH A O   1 
HETATM 4461 O  O   . HOH N 5 .   ? -24.08981 8.55001   22.58302  1.000 55.90458  ? 401 HOH B O   1 
HETATM 4462 O  O   . HOH N 5 .   ? -21.42741 10.99982  17.35778  1.000 61.88679  ? 402 HOH B O   1 
HETATM 4463 O  O   . HOH N 5 .   ? -25.59185 4.99082   12.94805  1.000 51.01509  ? 403 HOH B O   1 
HETATM 4464 O  O   . HOH N 5 .   ? -24.90600 -9.06266  6.77326   1.000 63.24494  ? 404 HOH B O   1 
HETATM 4465 O  O   . HOH N 5 .   ? -33.75257 1.24806   1.08554   1.000 60.39264  ? 405 HOH B O   1 
HETATM 4466 O  O   . HOH N 5 .   ? -24.36301 13.87509  8.88974   1.000 60.12510  ? 406 HOH B O   1 
HETATM 4467 O  O   . HOH N 5 .   ? -28.19708 -20.06524 7.74095   1.000 46.38469  ? 407 HOH B O   1 
HETATM 4468 O  O   . HOH N 5 .   ? -25.55888 8.53203   20.26614  1.000 54.37226  ? 408 HOH B O   1 
HETATM 4469 O  O   . HOH N 5 .   ? -24.95946 7.99919   13.43481  1.000 37.54341  ? 409 HOH B O   1 
HETATM 4470 O  O   . HOH N 5 .   ? -26.13858 22.57629  22.94582  1.000 67.03989  ? 410 HOH B O   1 
HETATM 4471 O  O   . HOH N 5 .   ? -26.19538 13.03884  7.46203   1.000 58.76213  ? 411 HOH B O   1 
HETATM 4472 O  O   . HOH N 5 .   ? -34.37580 -11.17694 23.82620  1.000 76.67638  ? 412 HOH B O   1 
HETATM 4473 O  O   . HOH N 5 .   ? -28.82678 0.79660   0.19229   1.000 54.53172  ? 413 HOH B O   1 
HETATM 4474 O  O   . HOH N 5 .   ? -29.28047 -21.33407 12.06368  1.000 70.65790  ? 414 HOH B O   1 
HETATM 4475 O  O   . HOH N 5 .   ? -41.18324 -16.24920 -3.05854  1.000 58.06777  ? 415 HOH B O   1 
HETATM 4476 O  O   . HOH N 5 .   ? -31.18130 2.53817   6.15066   1.000 41.20319  ? 416 HOH B O   1 
HETATM 4477 O  O   . HOH N 5 .   ? -14.76963 9.91527   -7.23294  1.000 64.48084  ? 417 HOH B O   1 
HETATM 4478 O  O   . HOH N 5 .   ? -29.21245 8.62090   14.75373  1.000 68.94476  ? 418 HOH B O   1 
HETATM 4479 O  O   . HOH N 5 .   ? -8.71757  12.42468  22.38401  1.000 56.48171  ? 419 HOH B O   1 
HETATM 4480 O  O   . HOH N 5 .   ? -22.42494 -8.47557  2.78138   1.000 70.98317  ? 420 HOH B O   1 
HETATM 4481 O  O   . HOH N 5 .   ? -9.14527  2.98674   6.19770   1.000 62.51163  ? 421 HOH B O   1 
HETATM 4482 O  O   . HOH N 5 .   ? -36.92695 3.25676   -4.05525  1.000 59.98003  ? 422 HOH B O   1 
# 
