data_7I2U
# 
_entry.id   7I2U 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   7I2U         pdb_00007i2u 10.2210/pdb7i2u/pdb 
WWPDB D_1001408245 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-02 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.entry_id                        7I2U 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.recvd_initial_deposition_date   2025-03-06 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.SG_entry                        ? 
_pdbx_database_status.pdb_format_compatible           Y 
_pdbx_database_status.methods_development_category    ? 
# 
_pdbx_contact_author.id                 1 
_pdbx_contact_author.email              fr193@cabm.rutgers.edu 
_pdbx_contact_author.name_first         'Francesc Xavier' 
_pdbx_contact_author.name_last          Ruiz 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0457-0030 
_pdbx_contact_author.name_mi            ? 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Aschenbrenner, J.C.' 1  ? 
'Saini, M.'           2  ? 
'Chopra, A.'          3  ? 
'Marples, P.G.'       4  ? 
'Balcomb, B.H.'       5  ? 
'Lithgo, R.M.'        6  ? 
'Fearon, D.'          7  ? 
'von Delft, F.'       8  ? 
'Ruiz, F.X.'          9  ? 
'Arnold, E.'          10 ? 
# 
_citation.id                        primary 
_citation.title                     
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_volume            ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.year                      ? 
_citation.journal_id_ASTM           ? 
_citation.country                   ? 
_citation.journal_id_ISSN           ? 
_citation.journal_id_CSD            0353 
_citation.book_publisher            ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_DOI      ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.identifier_ORCID 
_citation_author.ordinal 
primary 'Aschenbrenner, J.C.' ? 1  
primary 'Saini, M.'           ? 2  
primary 'Chopra, A.'          ? 3  
primary 'Marples, P.G.'       ? 4  
primary 'Balcomb, B.H.'       ? 5  
primary 'Lithgo, R.M.'        ? 6  
primary 'Fearon, D.'          ? 7  
primary 'von Delft, F.'       ? 8  
primary 'Ruiz, F.X.'          ? 9  
primary 'Arnold, E.'          ? 10 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'NS5 RNA-dependent RNA polymerase'                     73890.008 1   ? ? ? ? 
2 non-polymer syn 'ZINC ION'                                             65.409    2   ? ? ? ? 
3 non-polymer syn '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                 195.237   1   ? ? ? ? 
4 non-polymer syn 'DIMETHYL SULFOXIDE'                                   78.133    2   ? ? ? ? 
5 non-polymer syn 'PHOSPHATE ION'                                        94.971    2   ? ? ? ? 
6 non-polymer syn 'DI(HYDROXYETHYL)ETHER'                                106.120   1   ? ? ? ? 
7 non-polymer syn 'CHLORIDE ION'                                         35.453    1   ? ? ? ? 
8 non-polymer syn '(1-benzofuran-2-yl)(4-methylpiperidin-1-yl)methanone' 243.301   1   ? ? ? ? 
9 water       nat water                                                  18.015    292 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION'                                             ZN  
3 '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                 MES 
4 'DIMETHYL SULFOXIDE'                                   DMS 
5 'PHOSPHATE ION'                                        PO4 
6 'DI(HYDROXYETHYL)ETHER'                                PEG 
7 'CHLORIDE ION'                                         CL  
8 '(1-benzofuran-2-yl)(4-methylpiperidin-1-yl)methanone' LQI 
9 water                                                  HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PRO n 
1 3   GLY n 
1 4   ILE n 
1 5   GLU n 
1 6   SER n 
1 7   GLU n 
1 8   THR n 
1 9   PRO n 
1 10  ASN n 
1 11  LEU n 
1 12  ASP n 
1 13  ILE n 
1 14  ILE n 
1 15  GLY n 
1 16  LYS n 
1 17  ARG n 
1 18  ILE n 
1 19  GLU n 
1 20  LYS n 
1 21  ILE n 
1 22  LYS n 
1 23  GLN n 
1 24  GLU n 
1 25  HIS n 
1 26  GLU n 
1 27  THR n 
1 28  SER n 
1 29  TRP n 
1 30  HIS n 
1 31  TYR n 
1 32  ASP n 
1 33  GLN n 
1 34  ASP n 
1 35  HIS n 
1 36  PRO n 
1 37  TYR n 
1 38  LYS n 
1 39  THR n 
1 40  TRP n 
1 41  ALA n 
1 42  TYR n 
1 43  HIS n 
1 44  GLY n 
1 45  SER n 
1 46  TYR n 
1 47  GLU n 
1 48  THR n 
1 49  LYS n 
1 50  GLN n 
1 51  THR n 
1 52  GLY n 
1 53  SER n 
1 54  ALA n 
1 55  SER n 
1 56  SER n 
1 57  MET n 
1 58  VAL n 
1 59  ASN n 
1 60  GLY n 
1 61  VAL n 
1 62  VAL n 
1 63  ARG n 
1 64  LEU n 
1 65  LEU n 
1 66  THR n 
1 67  LYS n 
1 68  PRO n 
1 69  TRP n 
1 70  ASP n 
1 71  ILE n 
1 72  ILE n 
1 73  PRO n 
1 74  MET n 
1 75  VAL n 
1 76  THR n 
1 77  GLN n 
1 78  MET n 
1 79  ALA n 
1 80  MET n 
1 81  THR n 
1 82  ASP n 
1 83  THR n 
1 84  THR n 
1 85  PRO n 
1 86  PHE n 
1 87  GLY n 
1 88  GLN n 
1 89  GLN n 
1 90  ARG n 
1 91  VAL n 
1 92  PHE n 
1 93  LYS n 
1 94  GLU n 
1 95  LYS n 
1 96  VAL n 
1 97  ASP n 
1 98  THR n 
1 99  ARG n 
1 100 THR n 
1 101 GLN n 
1 102 GLU n 
1 103 PRO n 
1 104 LYS n 
1 105 GLU n 
1 106 GLY n 
1 107 THR n 
1 108 LYS n 
1 109 LYS n 
1 110 LEU n 
1 111 MET n 
1 112 LYS n 
1 113 ILE n 
1 114 THR n 
1 115 ALA n 
1 116 GLU n 
1 117 TRP n 
1 118 LEU n 
1 119 TRP n 
1 120 LYS n 
1 121 GLU n 
1 122 LEU n 
1 123 GLY n 
1 124 LYS n 
1 125 LYS n 
1 126 LYS n 
1 127 THR n 
1 128 PRO n 
1 129 ARG n 
1 130 MET n 
1 131 CYS n 
1 132 THR n 
1 133 ARG n 
1 134 GLU n 
1 135 GLU n 
1 136 PHE n 
1 137 THR n 
1 138 ARG n 
1 139 LYS n 
1 140 VAL n 
1 141 ARG n 
1 142 SER n 
1 143 ASN n 
1 144 ALA n 
1 145 ALA n 
1 146 LEU n 
1 147 GLY n 
1 148 ALA n 
1 149 ILE n 
1 150 PHE n 
1 151 THR n 
1 152 ASP n 
1 153 GLU n 
1 154 ASN n 
1 155 LYS n 
1 156 TRP n 
1 157 LYS n 
1 158 SER n 
1 159 ALA n 
1 160 ARG n 
1 161 GLU n 
1 162 ALA n 
1 163 VAL n 
1 164 GLU n 
1 165 ASP n 
1 166 SER n 
1 167 GLY n 
1 168 PHE n 
1 169 TRP n 
1 170 GLU n 
1 171 LEU n 
1 172 VAL n 
1 173 ASP n 
1 174 LYS n 
1 175 GLU n 
1 176 ARG n 
1 177 ASN n 
1 178 LEU n 
1 179 HIS n 
1 180 LEU n 
1 181 GLU n 
1 182 GLY n 
1 183 LYS n 
1 184 CYS n 
1 185 GLU n 
1 186 THR n 
1 187 CYS n 
1 188 VAL n 
1 189 TYR n 
1 190 ASN n 
1 191 MET n 
1 192 MET n 
1 193 GLY n 
1 194 LYS n 
1 195 ARG n 
1 196 GLU n 
1 197 LYS n 
1 198 LYS n 
1 199 LEU n 
1 200 GLY n 
1 201 GLU n 
1 202 PHE n 
1 203 GLY n 
1 204 LYS n 
1 205 ALA n 
1 206 LYS n 
1 207 GLY n 
1 208 SER n 
1 209 ARG n 
1 210 ALA n 
1 211 ILE n 
1 212 TRP n 
1 213 TYR n 
1 214 MET n 
1 215 TRP n 
1 216 LEU n 
1 217 GLY n 
1 218 ALA n 
1 219 ARG n 
1 220 PHE n 
1 221 LEU n 
1 222 GLU n 
1 223 PHE n 
1 224 GLU n 
1 225 ALA n 
1 226 LEU n 
1 227 GLY n 
1 228 PHE n 
1 229 LEU n 
1 230 ASN n 
1 231 GLU n 
1 232 ASP n 
1 233 HIS n 
1 234 TRP n 
1 235 PHE n 
1 236 SER n 
1 237 ARG n 
1 238 GLU n 
1 239 ASN n 
1 240 SER n 
1 241 LEU n 
1 242 SER n 
1 243 GLY n 
1 244 VAL n 
1 245 GLU n 
1 246 GLY n 
1 247 GLU n 
1 248 GLY n 
1 249 LEU n 
1 250 HIS n 
1 251 LYS n 
1 252 LEU n 
1 253 GLY n 
1 254 TYR n 
1 255 ILE n 
1 256 LEU n 
1 257 ARG n 
1 258 ASP n 
1 259 VAL n 
1 260 SER n 
1 261 LYS n 
1 262 LYS n 
1 263 GLU n 
1 264 GLY n 
1 265 GLY n 
1 266 ALA n 
1 267 MET n 
1 268 TYR n 
1 269 ALA n 
1 270 ASP n 
1 271 ASP n 
1 272 THR n 
1 273 ALA n 
1 274 GLY n 
1 275 TRP n 
1 276 ASP n 
1 277 THR n 
1 278 ARG n 
1 279 ILE n 
1 280 THR n 
1 281 LEU n 
1 282 GLU n 
1 283 ASP n 
1 284 LEU n 
1 285 LYS n 
1 286 ASN n 
1 287 GLU n 
1 288 GLU n 
1 289 MET n 
1 290 VAL n 
1 291 THR n 
1 292 ASN n 
1 293 HIS n 
1 294 MET n 
1 295 GLU n 
1 296 GLY n 
1 297 GLU n 
1 298 HIS n 
1 299 LYS n 
1 300 LYS n 
1 301 LEU n 
1 302 ALA n 
1 303 GLU n 
1 304 ALA n 
1 305 ILE n 
1 306 PHE n 
1 307 LYS n 
1 308 LEU n 
1 309 THR n 
1 310 TYR n 
1 311 GLN n 
1 312 ASN n 
1 313 LYS n 
1 314 VAL n 
1 315 VAL n 
1 316 ARG n 
1 317 VAL n 
1 318 GLN n 
1 319 ARG n 
1 320 PRO n 
1 321 THR n 
1 322 PRO n 
1 323 ARG n 
1 324 GLY n 
1 325 THR n 
1 326 VAL n 
1 327 MET n 
1 328 ASP n 
1 329 ILE n 
1 330 ILE n 
1 331 SER n 
1 332 ARG n 
1 333 ARG n 
1 334 ASP n 
1 335 GLN n 
1 336 ARG n 
1 337 GLY n 
1 338 SER n 
1 339 GLY n 
1 340 GLN n 
1 341 VAL n 
1 342 VAL n 
1 343 THR n 
1 344 TYR n 
1 345 GLY n 
1 346 LEU n 
1 347 ASN n 
1 348 THR n 
1 349 PHE n 
1 350 THR n 
1 351 ASN n 
1 352 MET n 
1 353 GLU n 
1 354 ALA n 
1 355 GLN n 
1 356 LEU n 
1 357 ILE n 
1 358 ARG n 
1 359 GLN n 
1 360 MET n 
1 361 GLU n 
1 362 GLY n 
1 363 GLU n 
1 364 GLY n 
1 365 VAL n 
1 366 PHE n 
1 367 LYS n 
1 368 SER n 
1 369 ILE n 
1 370 GLN n 
1 371 HIS n 
1 372 LEU n 
1 373 THR n 
1 374 VAL n 
1 375 THR n 
1 376 GLU n 
1 377 GLU n 
1 378 ILE n 
1 379 ALA n 
1 380 VAL n 
1 381 LYS n 
1 382 ASN n 
1 383 TRP n 
1 384 LEU n 
1 385 VAL n 
1 386 ARG n 
1 387 VAL n 
1 388 GLY n 
1 389 ARG n 
1 390 GLU n 
1 391 ARG n 
1 392 LEU n 
1 393 SER n 
1 394 ARG n 
1 395 MET n 
1 396 ALA n 
1 397 ILE n 
1 398 SER n 
1 399 GLY n 
1 400 ASP n 
1 401 ASP n 
1 402 CYS n 
1 403 VAL n 
1 404 VAL n 
1 405 LYS n 
1 406 PRO n 
1 407 LEU n 
1 408 ASP n 
1 409 ASP n 
1 410 ARG n 
1 411 PHE n 
1 412 ALA n 
1 413 SER n 
1 414 ALA n 
1 415 LEU n 
1 416 THR n 
1 417 ALA n 
1 418 LEU n 
1 419 ASN n 
1 420 ASP n 
1 421 MET n 
1 422 GLY n 
1 423 LYS n 
1 424 VAL n 
1 425 ARG n 
1 426 LYS n 
1 427 ASP n 
1 428 ILE n 
1 429 GLN n 
1 430 GLN n 
1 431 TRP n 
1 432 GLU n 
1 433 PRO n 
1 434 SER n 
1 435 ARG n 
1 436 GLY n 
1 437 TRP n 
1 438 ASN n 
1 439 ASP n 
1 440 TRP n 
1 441 THR n 
1 442 GLN n 
1 443 VAL n 
1 444 PRO n 
1 445 PHE n 
1 446 CYS n 
1 447 SER n 
1 448 HIS n 
1 449 HIS n 
1 450 PHE n 
1 451 HIS n 
1 452 GLU n 
1 453 LEU n 
1 454 ILE n 
1 455 MET n 
1 456 LYS n 
1 457 ASP n 
1 458 GLY n 
1 459 ARG n 
1 460 VAL n 
1 461 LEU n 
1 462 VAL n 
1 463 VAL n 
1 464 PRO n 
1 465 CYS n 
1 466 ARG n 
1 467 ASN n 
1 468 GLN n 
1 469 ASP n 
1 470 GLU n 
1 471 LEU n 
1 472 ILE n 
1 473 GLY n 
1 474 ARG n 
1 475 ALA n 
1 476 ARG n 
1 477 ILE n 
1 478 SER n 
1 479 GLN n 
1 480 GLY n 
1 481 ALA n 
1 482 GLY n 
1 483 TRP n 
1 484 SER n 
1 485 LEU n 
1 486 ARG n 
1 487 GLU n 
1 488 THR n 
1 489 ALA n 
1 490 CYS n 
1 491 LEU n 
1 492 GLY n 
1 493 LYS n 
1 494 SER n 
1 495 TYR n 
1 496 ALA n 
1 497 GLN n 
1 498 MET n 
1 499 TRP n 
1 500 SER n 
1 501 LEU n 
1 502 MET n 
1 503 TYR n 
1 504 PHE n 
1 505 HIS n 
1 506 ARG n 
1 507 ARG n 
1 508 ASP n 
1 509 LEU n 
1 510 ARG n 
1 511 LEU n 
1 512 ALA n 
1 513 ALA n 
1 514 ASN n 
1 515 ALA n 
1 516 ILE n 
1 517 CYS n 
1 518 SER n 
1 519 ALA n 
1 520 VAL n 
1 521 PRO n 
1 522 SER n 
1 523 HIS n 
1 524 TRP n 
1 525 VAL n 
1 526 PRO n 
1 527 THR n 
1 528 SER n 
1 529 ARG n 
1 530 THR n 
1 531 THR n 
1 532 TRP n 
1 533 SER n 
1 534 ILE n 
1 535 HIS n 
1 536 ALA n 
1 537 THR n 
1 538 HIS n 
1 539 GLU n 
1 540 TRP n 
1 541 MET n 
1 542 THR n 
1 543 THR n 
1 544 GLU n 
1 545 ASP n 
1 546 MET n 
1 547 LEU n 
1 548 THR n 
1 549 VAL n 
1 550 TRP n 
1 551 ASN n 
1 552 ARG n 
1 553 VAL n 
1 554 TRP n 
1 555 ILE n 
1 556 GLN n 
1 557 GLU n 
1 558 ASN n 
1 559 PRO n 
1 560 TRP n 
1 561 MET n 
1 562 GLU n 
1 563 ASP n 
1 564 LYS n 
1 565 THR n 
1 566 PRO n 
1 567 VAL n 
1 568 GLU n 
1 569 SER n 
1 570 TRP n 
1 571 GLU n 
1 572 GLU n 
1 573 ILE n 
1 574 PRO n 
1 575 TYR n 
1 576 LEU n 
1 577 GLY n 
1 578 LYS n 
1 579 ARG n 
1 580 GLU n 
1 581 ASP n 
1 582 GLN n 
1 583 TRP n 
1 584 CYS n 
1 585 GLY n 
1 586 SER n 
1 587 LEU n 
1 588 ILE n 
1 589 GLY n 
1 590 LEU n 
1 591 THR n 
1 592 SER n 
1 593 ARG n 
1 594 ALA n 
1 595 THR n 
1 596 TRP n 
1 597 ALA n 
1 598 LYS n 
1 599 ASN n 
1 600 ILE n 
1 601 GLN n 
1 602 THR n 
1 603 ALA n 
1 604 ILE n 
1 605 ASN n 
1 606 GLN n 
1 607 VAL n 
1 608 ARG n 
1 609 SER n 
1 610 LEU n 
1 611 ILE n 
1 612 GLY n 
1 613 ASN n 
1 614 GLU n 
1 615 GLU n 
1 616 TYR n 
1 617 THR n 
1 618 ASP n 
1 619 TYR n 
1 620 MET n 
1 621 PRO n 
1 622 SER n 
1 623 MET n 
1 624 LYS n 
1 625 ARG n 
1 626 PHE n 
1 627 ARG n 
1 628 ARG n 
1 629 GLU n 
1 630 GLU n 
1 631 GLU n 
1 632 GLU n 
1 633 ALA n 
1 634 GLY n 
1 635 VAL n 
1 636 LEU n 
1 637 TRP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   637 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'dengue virus type 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     11060 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                                ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                               ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                             ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                        ? 'C4 H7 N O4'     133.103 
CL  non-polymer         . 'CHLORIDE ION'                                         ? 'Cl -1'          35.453  
CYS 'L-peptide linking' y CYSTEINE                                               ? 'C3 H7 N O2 S'   121.158 
DMS non-polymer         . 'DIMETHYL SULFOXIDE'                                   ? 'C2 H6 O S'      78.133  
GLN 'L-peptide linking' y GLUTAMINE                                              ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                        ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                                ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                              ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                                  ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                             ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                                ? 'C6 H13 N O2'    131.173 
LQI non-polymer         . '(1-benzofuran-2-yl)(4-methylpiperidin-1-yl)methanone' ? 'C15 H17 N O2'   243.301 
LYS 'L-peptide linking' y LYSINE                                                 ? 'C6 H15 N2 O2 1' 147.195 
MES non-polymer         . '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                 ? 'C6 H13 N O4 S'  195.237 
MET 'L-peptide linking' y METHIONINE                                             ? 'C5 H11 N O2 S'  149.211 
PEG non-polymer         . 'DI(HYDROXYETHYL)ETHER'                                ? 'C4 H10 O3'      106.120 
PHE 'L-peptide linking' y PHENYLALANINE                                          ? 'C9 H11 N O2'    165.189 
PO4 non-polymer         . 'PHOSPHATE ION'                                        ? 'O4 P -3'        94.971  
PRO 'L-peptide linking' y PROLINE                                                ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                                 ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                              ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                             ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                               ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                                                 ? 'C5 H11 N O2'    117.146 
ZN  non-polymer         . 'ZINC ION'                                             ? 'Zn 2'           65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   264 ?   ?   ?   A . n 
A 1 2   PRO 2   265 ?   ?   ?   A . n 
A 1 3   GLY 3   266 ?   ?   ?   A . n 
A 1 4   ILE 4   267 ?   ?   ?   A . n 
A 1 5   GLU 5   268 ?   ?   ?   A . n 
A 1 6   SER 6   269 ?   ?   ?   A . n 
A 1 7   GLU 7   270 ?   ?   ?   A . n 
A 1 8   THR 8   271 ?   ?   ?   A . n 
A 1 9   PRO 9   272 ?   ?   ?   A . n 
A 1 10  ASN 10  273 273 ASN ASN A . n 
A 1 11  LEU 11  274 274 LEU LEU A . n 
A 1 12  ASP 12  275 275 ASP ASP A . n 
A 1 13  ILE 13  276 276 ILE ILE A . n 
A 1 14  ILE 14  277 277 ILE ILE A . n 
A 1 15  GLY 15  278 278 GLY GLY A . n 
A 1 16  LYS 16  279 279 LYS LYS A . n 
A 1 17  ARG 17  280 280 ARG ARG A . n 
A 1 18  ILE 18  281 281 ILE ILE A . n 
A 1 19  GLU 19  282 282 GLU GLU A . n 
A 1 20  LYS 20  283 283 LYS LYS A . n 
A 1 21  ILE 21  284 284 ILE ILE A . n 
A 1 22  LYS 22  285 285 LYS LYS A . n 
A 1 23  GLN 23  286 286 GLN GLN A . n 
A 1 24  GLU 24  287 287 GLU GLU A . n 
A 1 25  HIS 25  288 288 HIS HIS A . n 
A 1 26  GLU 26  289 289 GLU GLU A . n 
A 1 27  THR 27  290 290 THR THR A . n 
A 1 28  SER 28  291 291 SER SER A . n 
A 1 29  TRP 29  292 292 TRP TRP A . n 
A 1 30  HIS 30  293 293 HIS HIS A . n 
A 1 31  TYR 31  294 294 TYR TYR A . n 
A 1 32  ASP 32  295 295 ASP ASP A . n 
A 1 33  GLN 33  296 296 GLN GLN A . n 
A 1 34  ASP 34  297 297 ASP ASP A . n 
A 1 35  HIS 35  298 298 HIS HIS A . n 
A 1 36  PRO 36  299 299 PRO PRO A . n 
A 1 37  TYR 37  300 300 TYR TYR A . n 
A 1 38  LYS 38  301 301 LYS LYS A . n 
A 1 39  THR 39  302 302 THR THR A . n 
A 1 40  TRP 40  303 303 TRP TRP A . n 
A 1 41  ALA 41  304 304 ALA ALA A . n 
A 1 42  TYR 42  305 305 TYR TYR A . n 
A 1 43  HIS 43  306 306 HIS HIS A . n 
A 1 44  GLY 44  307 307 GLY GLY A . n 
A 1 45  SER 45  308 308 SER SER A . n 
A 1 46  TYR 46  309 309 TYR TYR A . n 
A 1 47  GLU 47  310 310 GLU GLU A . n 
A 1 48  THR 48  311 311 THR THR A . n 
A 1 49  LYS 49  312 312 LYS LYS A . n 
A 1 50  GLN 50  313 313 GLN GLN A . n 
A 1 51  THR 51  314 314 THR THR A . n 
A 1 52  GLY 52  315 ?   ?   ?   A . n 
A 1 53  SER 53  316 ?   ?   ?   A . n 
A 1 54  ALA 54  317 317 ALA ALA A . n 
A 1 55  SER 55  318 318 SER SER A . n 
A 1 56  SER 56  319 319 SER SER A . n 
A 1 57  MET 57  320 320 MET MET A . n 
A 1 58  VAL 58  321 321 VAL VAL A . n 
A 1 59  ASN 59  322 322 ASN ASN A . n 
A 1 60  GLY 60  323 323 GLY GLY A . n 
A 1 61  VAL 61  324 324 VAL VAL A . n 
A 1 62  VAL 62  325 325 VAL VAL A . n 
A 1 63  ARG 63  326 326 ARG ARG A . n 
A 1 64  LEU 64  327 327 LEU LEU A . n 
A 1 65  LEU 65  328 328 LEU LEU A . n 
A 1 66  THR 66  329 329 THR THR A . n 
A 1 67  LYS 67  330 330 LYS LYS A . n 
A 1 68  PRO 68  331 331 PRO PRO A . n 
A 1 69  TRP 69  332 332 TRP TRP A . n 
A 1 70  ASP 70  333 333 ASP ASP A . n 
A 1 71  ILE 71  334 334 ILE ILE A . n 
A 1 72  ILE 72  335 335 ILE ILE A . n 
A 1 73  PRO 73  336 336 PRO PRO A . n 
A 1 74  MET 74  337 337 MET MET A . n 
A 1 75  VAL 75  338 338 VAL VAL A . n 
A 1 76  THR 76  339 339 THR THR A . n 
A 1 77  GLN 77  340 340 GLN GLN A . n 
A 1 78  MET 78  341 341 MET MET A . n 
A 1 79  ALA 79  342 342 ALA ALA A . n 
A 1 80  MET 80  343 343 MET MET A . n 
A 1 81  THR 81  344 344 THR GLY A . n 
A 1 82  ASP 82  345 ?   ?   ?   A . n 
A 1 83  THR 83  346 ?   ?   ?   A . n 
A 1 84  THR 84  347 ?   ?   ?   A . n 
A 1 85  PRO 85  348 ?   ?   ?   A . n 
A 1 86  PHE 86  349 ?   ?   ?   A . n 
A 1 87  GLY 87  350 ?   ?   ?   A . n 
A 1 88  GLN 88  351 ?   ?   ?   A . n 
A 1 89  GLN 89  352 ?   ?   ?   A . n 
A 1 90  ARG 90  353 ?   ?   ?   A . n 
A 1 91  VAL 91  354 ?   ?   ?   A . n 
A 1 92  PHE 92  355 ?   ?   ?   A . n 
A 1 93  LYS 93  356 356 LYS LYS A . n 
A 1 94  GLU 94  357 357 GLU GLU A . n 
A 1 95  LYS 95  358 358 LYS LYS A . n 
A 1 96  VAL 96  359 359 VAL VAL A . n 
A 1 97  ASP 97  360 360 ASP ASP A . n 
A 1 98  THR 98  361 361 THR THR A . n 
A 1 99  ARG 99  362 362 ARG ARG A . n 
A 1 100 THR 100 363 363 THR THR A . n 
A 1 101 GLN 101 364 364 GLN GLN A . n 
A 1 102 GLU 102 365 365 GLU GLU A . n 
A 1 103 PRO 103 366 366 PRO PRO A . n 
A 1 104 LYS 104 367 367 LYS LYS A . n 
A 1 105 GLU 105 368 368 GLU GLU A . n 
A 1 106 GLY 106 369 369 GLY GLY A . n 
A 1 107 THR 107 370 370 THR THR A . n 
A 1 108 LYS 108 371 371 LYS LYS A . n 
A 1 109 LYS 109 372 372 LYS LYS A . n 
A 1 110 LEU 110 373 373 LEU LEU A . n 
A 1 111 MET 111 374 374 MET MET A . n 
A 1 112 LYS 112 375 375 LYS LYS A . n 
A 1 113 ILE 113 376 376 ILE ILE A . n 
A 1 114 THR 114 377 377 THR THR A . n 
A 1 115 ALA 115 378 378 ALA ALA A . n 
A 1 116 GLU 116 379 379 GLU GLU A . n 
A 1 117 TRP 117 380 380 TRP TRP A . n 
A 1 118 LEU 118 381 381 LEU LEU A . n 
A 1 119 TRP 119 382 382 TRP TRP A . n 
A 1 120 LYS 120 383 383 LYS LYS A . n 
A 1 121 GLU 121 384 384 GLU GLU A . n 
A 1 122 LEU 122 385 385 LEU LEU A . n 
A 1 123 GLY 123 386 386 GLY GLY A . n 
A 1 124 LYS 124 387 387 LYS LYS A . n 
A 1 125 LYS 125 388 388 LYS LYS A . n 
A 1 126 LYS 126 389 389 LYS LYS A . n 
A 1 127 THR 127 390 390 THR THR A . n 
A 1 128 PRO 128 391 391 PRO PRO A . n 
A 1 129 ARG 129 392 392 ARG ARG A . n 
A 1 130 MET 130 393 393 MET MET A . n 
A 1 131 CYS 131 394 394 CYS CYS A . n 
A 1 132 THR 132 395 395 THR THR A . n 
A 1 133 ARG 133 396 396 ARG ARG A . n 
A 1 134 GLU 134 397 397 GLU GLU A . n 
A 1 135 GLU 135 398 398 GLU GLU A . n 
A 1 136 PHE 136 399 399 PHE PHE A . n 
A 1 137 THR 137 400 400 THR THR A . n 
A 1 138 ARG 138 401 401 ARG ARG A . n 
A 1 139 LYS 139 402 402 LYS LYS A . n 
A 1 140 VAL 140 403 403 VAL VAL A . n 
A 1 141 ARG 141 404 404 ARG ARG A . n 
A 1 142 SER 142 405 405 SER SER A . n 
A 1 143 ASN 143 406 406 ASN ASN A . n 
A 1 144 ALA 144 407 407 ALA ALA A . n 
A 1 145 ALA 145 408 408 ALA ALA A . n 
A 1 146 LEU 146 409 409 LEU LEU A . n 
A 1 147 GLY 147 410 410 GLY GLY A . n 
A 1 148 ALA 148 411 411 ALA ALA A . n 
A 1 149 ILE 149 412 412 ILE ILE A . n 
A 1 150 PHE 150 413 ?   ?   ?   A . n 
A 1 151 THR 151 414 ?   ?   ?   A . n 
A 1 152 ASP 152 415 ?   ?   ?   A . n 
A 1 153 GLU 153 416 ?   ?   ?   A . n 
A 1 154 ASN 154 417 ?   ?   ?   A . n 
A 1 155 LYS 155 418 418 LYS LYS A . n 
A 1 156 TRP 156 419 419 TRP TRP A . n 
A 1 157 LYS 157 420 420 LYS LYS A . n 
A 1 158 SER 158 421 421 SER SER A . n 
A 1 159 ALA 159 422 422 ALA ALA A . n 
A 1 160 ARG 160 423 423 ARG ARG A . n 
A 1 161 GLU 161 424 424 GLU GLU A . n 
A 1 162 ALA 162 425 425 ALA ALA A . n 
A 1 163 VAL 163 426 426 VAL VAL A . n 
A 1 164 GLU 164 427 427 GLU GLU A . n 
A 1 165 ASP 165 428 428 ASP ASP A . n 
A 1 166 SER 166 429 429 SER SER A . n 
A 1 167 GLY 167 430 430 GLY GLY A . n 
A 1 168 PHE 168 431 431 PHE PHE A . n 
A 1 169 TRP 169 432 432 TRP TRP A . n 
A 1 170 GLU 170 433 433 GLU GLU A . n 
A 1 171 LEU 171 434 434 LEU LEU A . n 
A 1 172 VAL 172 435 435 VAL VAL A . n 
A 1 173 ASP 173 436 436 ASP ASP A . n 
A 1 174 LYS 174 437 437 LYS LYS A . n 
A 1 175 GLU 175 438 438 GLU GLU A . n 
A 1 176 ARG 176 439 439 ARG ARG A . n 
A 1 177 ASN 177 440 440 ASN ASN A . n 
A 1 178 LEU 178 441 441 LEU LEU A . n 
A 1 179 HIS 179 442 442 HIS HIS A . n 
A 1 180 LEU 180 443 443 LEU LEU A . n 
A 1 181 GLU 181 444 444 GLU GLU A . n 
A 1 182 GLY 182 445 445 GLY GLY A . n 
A 1 183 LYS 183 446 446 LYS LYS A . n 
A 1 184 CYS 184 447 447 CYS CYS A . n 
A 1 185 GLU 185 448 448 GLU GLU A . n 
A 1 186 THR 186 449 449 THR THR A . n 
A 1 187 CYS 187 450 450 CYS CYS A . n 
A 1 188 VAL 188 451 451 VAL VAL A . n 
A 1 189 TYR 189 452 452 TYR TYR A . n 
A 1 190 ASN 190 453 453 ASN ASN A . n 
A 1 191 MET 191 454 454 MET MET A . n 
A 1 192 MET 192 455 455 MET MET A . n 
A 1 193 GLY 193 456 ?   ?   ?   A . n 
A 1 194 LYS 194 457 ?   ?   ?   A . n 
A 1 195 ARG 195 458 ?   ?   ?   A . n 
A 1 196 GLU 196 459 ?   ?   ?   A . n 
A 1 197 LYS 197 460 ?   ?   ?   A . n 
A 1 198 LYS 198 461 ?   ?   ?   A . n 
A 1 199 LEU 199 462 ?   ?   ?   A . n 
A 1 200 GLY 200 463 ?   ?   ?   A . n 
A 1 201 GLU 201 464 ?   ?   ?   A . n 
A 1 202 PHE 202 465 ?   ?   ?   A . n 
A 1 203 GLY 203 466 ?   ?   ?   A . n 
A 1 204 LYS 204 467 ?   ?   ?   A . n 
A 1 205 ALA 205 468 ?   ?   ?   A . n 
A 1 206 LYS 206 469 ?   ?   ?   A . n 
A 1 207 GLY 207 470 ?   ?   ?   A . n 
A 1 208 SER 208 471 471 SER SER A . n 
A 1 209 ARG 209 472 472 ARG ARG A . n 
A 1 210 ALA 210 473 473 ALA ALA A . n 
A 1 211 ILE 211 474 474 ILE ILE A . n 
A 1 212 TRP 212 475 475 TRP TRP A . n 
A 1 213 TYR 213 476 476 TYR TYR A . n 
A 1 214 MET 214 477 477 MET MET A . n 
A 1 215 TRP 215 478 478 TRP TRP A . n 
A 1 216 LEU 216 479 479 LEU LEU A . n 
A 1 217 GLY 217 480 480 GLY GLY A . n 
A 1 218 ALA 218 481 481 ALA ALA A . n 
A 1 219 ARG 219 482 482 ARG ARG A . n 
A 1 220 PHE 220 483 483 PHE PHE A . n 
A 1 221 LEU 221 484 484 LEU LEU A . n 
A 1 222 GLU 222 485 485 GLU GLU A . n 
A 1 223 PHE 223 486 486 PHE PHE A . n 
A 1 224 GLU 224 487 487 GLU GLU A . n 
A 1 225 ALA 225 488 488 ALA ALA A . n 
A 1 226 LEU 226 489 489 LEU LEU A . n 
A 1 227 GLY 227 490 490 GLY GLY A . n 
A 1 228 PHE 228 491 491 PHE PHE A . n 
A 1 229 LEU 229 492 492 LEU LEU A . n 
A 1 230 ASN 230 493 493 ASN ASN A . n 
A 1 231 GLU 231 494 494 GLU GLU A . n 
A 1 232 ASP 232 495 495 ASP ASP A . n 
A 1 233 HIS 233 496 496 HIS HIS A . n 
A 1 234 TRP 234 497 497 TRP TRP A . n 
A 1 235 PHE 235 498 498 PHE PHE A . n 
A 1 236 SER 236 499 499 SER SER A . n 
A 1 237 ARG 237 500 500 ARG ARG A . n 
A 1 238 GLU 238 501 501 GLU GLU A . n 
A 1 239 ASN 239 502 502 ASN ASN A . n 
A 1 240 SER 240 503 503 SER SER A . n 
A 1 241 LEU 241 504 504 LEU LEU A . n 
A 1 242 SER 242 505 505 SER SER A . n 
A 1 243 GLY 243 506 506 GLY GLY A . n 
A 1 244 VAL 244 507 507 VAL VAL A . n 
A 1 245 GLU 245 508 508 GLU GLU A . n 
A 1 246 GLY 246 509 509 GLY GLY A . n 
A 1 247 GLU 247 510 510 GLU GLU A . n 
A 1 248 GLY 248 511 511 GLY GLY A . n 
A 1 249 LEU 249 512 512 LEU LEU A . n 
A 1 250 HIS 250 513 513 HIS HIS A . n 
A 1 251 LYS 251 514 514 LYS LYS A . n 
A 1 252 LEU 252 515 515 LEU LEU A . n 
A 1 253 GLY 253 516 516 GLY GLY A . n 
A 1 254 TYR 254 517 517 TYR TYR A . n 
A 1 255 ILE 255 518 518 ILE ILE A . n 
A 1 256 LEU 256 519 519 LEU LEU A . n 
A 1 257 ARG 257 520 520 ARG ARG A . n 
A 1 258 ASP 258 521 521 ASP ASP A . n 
A 1 259 VAL 259 522 522 VAL VAL A . n 
A 1 260 SER 260 523 523 SER SER A . n 
A 1 261 LYS 261 524 524 LYS LYS A . n 
A 1 262 LYS 262 525 525 LYS LYS A . n 
A 1 263 GLU 263 526 526 GLU GLU A . n 
A 1 264 GLY 264 527 527 GLY GLY A . n 
A 1 265 GLY 265 528 528 GLY GLY A . n 
A 1 266 ALA 266 529 529 ALA ALA A . n 
A 1 267 MET 267 530 530 MET MET A . n 
A 1 268 TYR 268 531 531 TYR TYR A . n 
A 1 269 ALA 269 532 532 ALA ALA A . n 
A 1 270 ASP 270 533 533 ASP ASP A . n 
A 1 271 ASP 271 534 534 ASP ASP A . n 
A 1 272 THR 272 535 535 THR THR A . n 
A 1 273 ALA 273 536 536 ALA ALA A . n 
A 1 274 GLY 274 537 537 GLY GLY A . n 
A 1 275 TRP 275 538 538 TRP TRP A . n 
A 1 276 ASP 276 539 539 ASP ASP A . n 
A 1 277 THR 277 540 540 THR THR A . n 
A 1 278 ARG 278 541 541 ARG ARG A . n 
A 1 279 ILE 279 542 542 ILE ILE A . n 
A 1 280 THR 280 543 543 THR THR A . n 
A 1 281 LEU 281 544 544 LEU LEU A . n 
A 1 282 GLU 282 545 545 GLU GLU A . n 
A 1 283 ASP 283 546 546 ASP ASP A . n 
A 1 284 LEU 284 547 547 LEU LEU A . n 
A 1 285 LYS 285 548 548 LYS LYS A . n 
A 1 286 ASN 286 549 549 ASN ASN A . n 
A 1 287 GLU 287 550 550 GLU GLU A . n 
A 1 288 GLU 288 551 551 GLU GLU A . n 
A 1 289 MET 289 552 552 MET MET A . n 
A 1 290 VAL 290 553 553 VAL VAL A . n 
A 1 291 THR 291 554 554 THR THR A . n 
A 1 292 ASN 292 555 555 ASN ASN A . n 
A 1 293 HIS 293 556 556 HIS HIS A . n 
A 1 294 MET 294 557 557 MET MET A . n 
A 1 295 GLU 295 558 558 GLU GLU A . n 
A 1 296 GLY 296 559 559 GLY GLY A . n 
A 1 297 GLU 297 560 560 GLU GLU A . n 
A 1 298 HIS 298 561 561 HIS HIS A . n 
A 1 299 LYS 299 562 562 LYS LYS A . n 
A 1 300 LYS 300 563 563 LYS LYS A . n 
A 1 301 LEU 301 564 564 LEU LEU A . n 
A 1 302 ALA 302 565 565 ALA ALA A . n 
A 1 303 GLU 303 566 566 GLU GLU A . n 
A 1 304 ALA 304 567 567 ALA ALA A . n 
A 1 305 ILE 305 568 568 ILE ILE A . n 
A 1 306 PHE 306 569 569 PHE PHE A . n 
A 1 307 LYS 307 570 570 LYS LYS A . n 
A 1 308 LEU 308 571 571 LEU LEU A . n 
A 1 309 THR 309 572 572 THR THR A . n 
A 1 310 TYR 310 573 573 TYR TYR A . n 
A 1 311 GLN 311 574 574 GLN GLN A . n 
A 1 312 ASN 312 575 575 ASN ASN A . n 
A 1 313 LYS 313 576 576 LYS LYS A . n 
A 1 314 VAL 314 577 577 VAL VAL A . n 
A 1 315 VAL 315 578 578 VAL VAL A . n 
A 1 316 ARG 316 579 579 ARG ARG A . n 
A 1 317 VAL 317 580 580 VAL VAL A . n 
A 1 318 GLN 318 581 581 GLN GLN A . n 
A 1 319 ARG 319 582 582 ARG ARG A . n 
A 1 320 PRO 320 583 583 PRO PRO A . n 
A 1 321 THR 321 584 584 THR THR A . n 
A 1 322 PRO 322 585 ?   ?   ?   A . n 
A 1 323 ARG 323 586 ?   ?   ?   A . n 
A 1 324 GLY 324 587 ?   ?   ?   A . n 
A 1 325 THR 325 588 588 THR THR A . n 
A 1 326 VAL 326 589 589 VAL VAL A . n 
A 1 327 MET 327 590 590 MET MET A . n 
A 1 328 ASP 328 591 591 ASP ASP A . n 
A 1 329 ILE 329 592 592 ILE ILE A . n 
A 1 330 ILE 330 593 593 ILE ILE A . n 
A 1 331 SER 331 594 594 SER SER A . n 
A 1 332 ARG 332 595 595 ARG ARG A . n 
A 1 333 ARG 333 596 596 ARG ARG A . n 
A 1 334 ASP 334 597 597 ASP ASP A . n 
A 1 335 GLN 335 598 598 GLN GLN A . n 
A 1 336 ARG 336 599 599 ARG ARG A . n 
A 1 337 GLY 337 600 600 GLY GLY A . n 
A 1 338 SER 338 601 601 SER SER A . n 
A 1 339 GLY 339 602 602 GLY GLY A . n 
A 1 340 GLN 340 603 603 GLN GLN A . n 
A 1 341 VAL 341 604 604 VAL VAL A . n 
A 1 342 VAL 342 605 605 VAL VAL A . n 
A 1 343 THR 343 606 606 THR THR A . n 
A 1 344 TYR 344 607 607 TYR TYR A . n 
A 1 345 GLY 345 608 608 GLY GLY A . n 
A 1 346 LEU 346 609 609 LEU LEU A . n 
A 1 347 ASN 347 610 610 ASN ASN A . n 
A 1 348 THR 348 611 611 THR THR A . n 
A 1 349 PHE 349 612 612 PHE PHE A . n 
A 1 350 THR 350 613 613 THR THR A . n 
A 1 351 ASN 351 614 614 ASN ASN A . n 
A 1 352 MET 352 615 615 MET MET A . n 
A 1 353 GLU 353 616 616 GLU GLU A . n 
A 1 354 ALA 354 617 617 ALA ALA A . n 
A 1 355 GLN 355 618 618 GLN GLN A . n 
A 1 356 LEU 356 619 619 LEU LEU A . n 
A 1 357 ILE 357 620 620 ILE ILE A . n 
A 1 358 ARG 358 621 621 ARG ARG A . n 
A 1 359 GLN 359 622 622 GLN GLN A . n 
A 1 360 MET 360 623 623 MET MET A . n 
A 1 361 GLU 361 624 624 GLU GLU A . n 
A 1 362 GLY 362 625 625 GLY GLY A . n 
A 1 363 GLU 363 626 626 GLU GLU A . n 
A 1 364 GLY 364 627 627 GLY GLY A . n 
A 1 365 VAL 365 628 628 VAL VAL A . n 
A 1 366 PHE 366 629 629 PHE PHE A . n 
A 1 367 LYS 367 630 630 LYS LYS A . n 
A 1 368 SER 368 631 631 SER SER A . n 
A 1 369 ILE 369 632 632 ILE ILE A . n 
A 1 370 GLN 370 633 633 GLN GLN A . n 
A 1 371 HIS 371 634 634 HIS HIS A . n 
A 1 372 LEU 372 635 635 LEU LEU A . n 
A 1 373 THR 373 636 636 THR THR A . n 
A 1 374 VAL 374 637 637 VAL VAL A . n 
A 1 375 THR 375 638 638 THR THR A . n 
A 1 376 GLU 376 639 639 GLU GLU A . n 
A 1 377 GLU 377 640 640 GLU GLU A . n 
A 1 378 ILE 378 641 641 ILE ILE A . n 
A 1 379 ALA 379 642 642 ALA ALA A . n 
A 1 380 VAL 380 643 643 VAL VAL A . n 
A 1 381 LYS 381 644 644 LYS LYS A . n 
A 1 382 ASN 382 645 645 ASN ASN A . n 
A 1 383 TRP 383 646 646 TRP TRP A . n 
A 1 384 LEU 384 647 647 LEU LEU A . n 
A 1 385 VAL 385 648 648 VAL VAL A . n 
A 1 386 ARG 386 649 649 ARG ARG A . n 
A 1 387 VAL 387 650 650 VAL VAL A . n 
A 1 388 GLY 388 651 651 GLY GLY A . n 
A 1 389 ARG 389 652 652 ARG ARG A . n 
A 1 390 GLU 390 653 653 GLU GLU A . n 
A 1 391 ARG 391 654 654 ARG ARG A . n 
A 1 392 LEU 392 655 655 LEU LEU A . n 
A 1 393 SER 393 656 656 SER SER A . n 
A 1 394 ARG 394 657 657 ARG ARG A . n 
A 1 395 MET 395 658 658 MET MET A . n 
A 1 396 ALA 396 659 659 ALA ALA A . n 
A 1 397 ILE 397 660 660 ILE ILE A . n 
A 1 398 SER 398 661 661 SER SER A . n 
A 1 399 GLY 399 662 662 GLY GLY A . n 
A 1 400 ASP 400 663 663 ASP ASP A . n 
A 1 401 ASP 401 664 664 ASP ASP A . n 
A 1 402 CYS 402 665 665 CYS CYS A . n 
A 1 403 VAL 403 666 666 VAL VAL A . n 
A 1 404 VAL 404 667 667 VAL VAL A . n 
A 1 405 LYS 405 668 668 LYS LYS A . n 
A 1 406 PRO 406 669 669 PRO PRO A . n 
A 1 407 LEU 407 670 670 LEU LEU A . n 
A 1 408 ASP 408 671 671 ASP ASP A . n 
A 1 409 ASP 409 672 672 ASP ASP A . n 
A 1 410 ARG 410 673 673 ARG ARG A . n 
A 1 411 PHE 411 674 674 PHE PHE A . n 
A 1 412 ALA 412 675 675 ALA ALA A . n 
A 1 413 SER 413 676 676 SER SER A . n 
A 1 414 ALA 414 677 677 ALA ALA A . n 
A 1 415 LEU 415 678 678 LEU LEU A . n 
A 1 416 THR 416 679 679 THR THR A . n 
A 1 417 ALA 417 680 680 ALA ALA A . n 
A 1 418 LEU 418 681 681 LEU LEU A . n 
A 1 419 ASN 419 682 682 ASN ASN A . n 
A 1 420 ASP 420 683 683 ASP ASP A . n 
A 1 421 MET 421 684 684 MET MET A . n 
A 1 422 GLY 422 685 685 GLY GLY A . n 
A 1 423 LYS 423 686 686 LYS LYS A . n 
A 1 424 VAL 424 687 687 VAL VAL A . n 
A 1 425 ARG 425 688 688 ARG ARG A . n 
A 1 426 LYS 426 689 689 LYS LYS A . n 
A 1 427 ASP 427 690 690 ASP ASP A . n 
A 1 428 ILE 428 691 691 ILE ILE A . n 
A 1 429 GLN 429 692 692 GLN GLN A . n 
A 1 430 GLN 430 693 693 GLN GLN A . n 
A 1 431 TRP 431 694 694 TRP TRP A . n 
A 1 432 GLU 432 695 695 GLU GLU A . n 
A 1 433 PRO 433 696 696 PRO PRO A . n 
A 1 434 SER 434 697 697 SER SER A . n 
A 1 435 ARG 435 698 698 ARG ARG A . n 
A 1 436 GLY 436 699 699 GLY GLY A . n 
A 1 437 TRP 437 700 700 TRP TRP A . n 
A 1 438 ASN 438 701 701 ASN ASN A . n 
A 1 439 ASP 439 702 702 ASP ASP A . n 
A 1 440 TRP 440 703 703 TRP TRP A . n 
A 1 441 THR 441 704 704 THR THR A . n 
A 1 442 GLN 442 705 705 GLN GLN A . n 
A 1 443 VAL 443 706 706 VAL VAL A . n 
A 1 444 PRO 444 707 707 PRO PRO A . n 
A 1 445 PHE 445 708 708 PHE PHE A . n 
A 1 446 CYS 446 709 709 CYS CYS A . n 
A 1 447 SER 447 710 710 SER SER A . n 
A 1 448 HIS 448 711 711 HIS HIS A . n 
A 1 449 HIS 449 712 712 HIS HIS A . n 
A 1 450 PHE 450 713 713 PHE PHE A . n 
A 1 451 HIS 451 714 714 HIS HIS A . n 
A 1 452 GLU 452 715 715 GLU GLU A . n 
A 1 453 LEU 453 716 716 LEU LEU A . n 
A 1 454 ILE 454 717 717 ILE ILE A . n 
A 1 455 MET 455 718 718 MET MET A . n 
A 1 456 LYS 456 719 719 LYS LYS A . n 
A 1 457 ASP 457 720 720 ASP ASP A . n 
A 1 458 GLY 458 721 721 GLY GLY A . n 
A 1 459 ARG 459 722 722 ARG ARG A . n 
A 1 460 VAL 460 723 723 VAL VAL A . n 
A 1 461 LEU 461 724 724 LEU LEU A . n 
A 1 462 VAL 462 725 725 VAL VAL A . n 
A 1 463 VAL 463 726 726 VAL VAL A . n 
A 1 464 PRO 464 727 727 PRO PRO A . n 
A 1 465 CYS 465 728 728 CYS CYS A . n 
A 1 466 ARG 466 729 729 ARG ARG A . n 
A 1 467 ASN 467 730 730 ASN ASN A . n 
A 1 468 GLN 468 731 731 GLN GLN A . n 
A 1 469 ASP 469 732 732 ASP ASP A . n 
A 1 470 GLU 470 733 733 GLU GLU A . n 
A 1 471 LEU 471 734 734 LEU LEU A . n 
A 1 472 ILE 472 735 735 ILE ILE A . n 
A 1 473 GLY 473 736 736 GLY GLY A . n 
A 1 474 ARG 474 737 737 ARG ARG A . n 
A 1 475 ALA 475 738 738 ALA ALA A . n 
A 1 476 ARG 476 739 739 ARG ARG A . n 
A 1 477 ILE 477 740 740 ILE ILE A . n 
A 1 478 SER 478 741 741 SER SER A . n 
A 1 479 GLN 479 742 742 GLN GLN A . n 
A 1 480 GLY 480 743 743 GLY GLY A . n 
A 1 481 ALA 481 744 744 ALA ALA A . n 
A 1 482 GLY 482 745 745 GLY GLY A . n 
A 1 483 TRP 483 746 746 TRP TRP A . n 
A 1 484 SER 484 747 747 SER SER A . n 
A 1 485 LEU 485 748 748 LEU LEU A . n 
A 1 486 ARG 486 749 749 ARG ARG A . n 
A 1 487 GLU 487 750 750 GLU GLU A . n 
A 1 488 THR 488 751 751 THR THR A . n 
A 1 489 ALA 489 752 752 ALA ALA A . n 
A 1 490 CYS 490 753 753 CYS CYS A . n 
A 1 491 LEU 491 754 754 LEU LEU A . n 
A 1 492 GLY 492 755 755 GLY GLY A . n 
A 1 493 LYS 493 756 756 LYS LYS A . n 
A 1 494 SER 494 757 757 SER SER A . n 
A 1 495 TYR 495 758 758 TYR TYR A . n 
A 1 496 ALA 496 759 759 ALA ALA A . n 
A 1 497 GLN 497 760 760 GLN GLN A . n 
A 1 498 MET 498 761 761 MET MET A . n 
A 1 499 TRP 499 762 762 TRP TRP A . n 
A 1 500 SER 500 763 763 SER SER A . n 
A 1 501 LEU 501 764 764 LEU LEU A . n 
A 1 502 MET 502 765 765 MET MET A . n 
A 1 503 TYR 503 766 766 TYR TYR A . n 
A 1 504 PHE 504 767 767 PHE PHE A . n 
A 1 505 HIS 505 768 768 HIS HIS A . n 
A 1 506 ARG 506 769 769 ARG ARG A . n 
A 1 507 ARG 507 770 770 ARG ARG A . n 
A 1 508 ASP 508 771 771 ASP ASP A . n 
A 1 509 LEU 509 772 772 LEU LEU A . n 
A 1 510 ARG 510 773 773 ARG ARG A . n 
A 1 511 LEU 511 774 774 LEU LEU A . n 
A 1 512 ALA 512 775 775 ALA ALA A . n 
A 1 513 ALA 513 776 776 ALA ALA A . n 
A 1 514 ASN 514 777 777 ASN ASN A . n 
A 1 515 ALA 515 778 778 ALA ALA A . n 
A 1 516 ILE 516 779 779 ILE ILE A . n 
A 1 517 CYS 517 780 780 CYS CYS A . n 
A 1 518 SER 518 781 781 SER SER A . n 
A 1 519 ALA 519 782 782 ALA ALA A . n 
A 1 520 VAL 520 783 783 VAL VAL A . n 
A 1 521 PRO 521 784 784 PRO PRO A . n 
A 1 522 SER 522 785 785 SER SER A . n 
A 1 523 HIS 523 786 786 HIS HIS A . n 
A 1 524 TRP 524 787 787 TRP TRP A . n 
A 1 525 VAL 525 788 788 VAL VAL A . n 
A 1 526 PRO 526 789 789 PRO PRO A . n 
A 1 527 THR 527 790 790 THR THR A . n 
A 1 528 SER 528 791 791 SER SER A . n 
A 1 529 ARG 529 792 792 ARG ARG A . n 
A 1 530 THR 530 793 793 THR THR A . n 
A 1 531 THR 531 794 794 THR THR A . n 
A 1 532 TRP 532 795 795 TRP TRP A . n 
A 1 533 SER 533 796 796 SER SER A . n 
A 1 534 ILE 534 797 797 ILE ILE A . n 
A 1 535 HIS 535 798 798 HIS HIS A . n 
A 1 536 ALA 536 799 799 ALA ALA A . n 
A 1 537 THR 537 800 800 THR THR A . n 
A 1 538 HIS 538 801 801 HIS HIS A . n 
A 1 539 GLU 539 802 802 GLU GLU A . n 
A 1 540 TRP 540 803 803 TRP TRP A . n 
A 1 541 MET 541 804 804 MET MET A . n 
A 1 542 THR 542 805 805 THR THR A . n 
A 1 543 THR 543 806 806 THR THR A . n 
A 1 544 GLU 544 807 807 GLU GLU A . n 
A 1 545 ASP 545 808 808 ASP ASP A . n 
A 1 546 MET 546 809 809 MET MET A . n 
A 1 547 LEU 547 810 810 LEU LEU A . n 
A 1 548 THR 548 811 811 THR THR A . n 
A 1 549 VAL 549 812 812 VAL VAL A . n 
A 1 550 TRP 550 813 813 TRP TRP A . n 
A 1 551 ASN 551 814 814 ASN ASN A . n 
A 1 552 ARG 552 815 815 ARG ARG A . n 
A 1 553 VAL 553 816 816 VAL VAL A . n 
A 1 554 TRP 554 817 817 TRP TRP A . n 
A 1 555 ILE 555 818 818 ILE ILE A . n 
A 1 556 GLN 556 819 819 GLN GLN A . n 
A 1 557 GLU 557 820 820 GLU GLU A . n 
A 1 558 ASN 558 821 821 ASN ASN A . n 
A 1 559 PRO 559 822 822 PRO PRO A . n 
A 1 560 TRP 560 823 823 TRP TRP A . n 
A 1 561 MET 561 824 824 MET MET A . n 
A 1 562 GLU 562 825 825 GLU GLU A . n 
A 1 563 ASP 563 826 826 ASP ASP A . n 
A 1 564 LYS 564 827 827 LYS LYS A . n 
A 1 565 THR 565 828 828 THR THR A . n 
A 1 566 PRO 566 829 829 PRO PRO A . n 
A 1 567 VAL 567 830 830 VAL VAL A . n 
A 1 568 GLU 568 831 831 GLU GLU A . n 
A 1 569 SER 569 832 832 SER SER A . n 
A 1 570 TRP 570 833 833 TRP TRP A . n 
A 1 571 GLU 571 834 834 GLU GLU A . n 
A 1 572 GLU 572 835 835 GLU GLU A . n 
A 1 573 ILE 573 836 836 ILE ILE A . n 
A 1 574 PRO 574 837 837 PRO PRO A . n 
A 1 575 TYR 575 838 838 TYR TYR A . n 
A 1 576 LEU 576 839 839 LEU LEU A . n 
A 1 577 GLY 577 840 840 GLY GLY A . n 
A 1 578 LYS 578 841 841 LYS LYS A . n 
A 1 579 ARG 579 842 842 ARG ARG A . n 
A 1 580 GLU 580 843 843 GLU GLU A . n 
A 1 581 ASP 581 844 844 ASP ASP A . n 
A 1 582 GLN 582 845 845 GLN GLN A . n 
A 1 583 TRP 583 846 846 TRP TRP A . n 
A 1 584 CYS 584 847 847 CYS CYS A . n 
A 1 585 GLY 585 848 848 GLY GLY A . n 
A 1 586 SER 586 849 849 SER SER A . n 
A 1 587 LEU 587 850 850 LEU LEU A . n 
A 1 588 ILE 588 851 851 ILE ILE A . n 
A 1 589 GLY 589 852 852 GLY GLY A . n 
A 1 590 LEU 590 853 853 LEU LEU A . n 
A 1 591 THR 591 854 854 THR THR A . n 
A 1 592 SER 592 855 855 SER SER A . n 
A 1 593 ARG 593 856 856 ARG ARG A . n 
A 1 594 ALA 594 857 857 ALA ALA A . n 
A 1 595 THR 595 858 858 THR THR A . n 
A 1 596 TRP 596 859 859 TRP TRP A . n 
A 1 597 ALA 597 860 860 ALA ALA A . n 
A 1 598 LYS 598 861 861 LYS LYS A . n 
A 1 599 ASN 599 862 862 ASN ASN A . n 
A 1 600 ILE 600 863 863 ILE ILE A . n 
A 1 601 GLN 601 864 864 GLN GLN A . n 
A 1 602 THR 602 865 865 THR THR A . n 
A 1 603 ALA 603 866 866 ALA ALA A . n 
A 1 604 ILE 604 867 867 ILE ILE A . n 
A 1 605 ASN 605 868 868 ASN ASN A . n 
A 1 606 GLN 606 869 869 GLN GLN A . n 
A 1 607 VAL 607 870 870 VAL VAL A . n 
A 1 608 ARG 608 871 871 ARG ARG A . n 
A 1 609 SER 609 872 872 SER SER A . n 
A 1 610 LEU 610 873 873 LEU LEU A . n 
A 1 611 ILE 611 874 874 ILE ILE A . n 
A 1 612 GLY 612 875 875 GLY GLY A . n 
A 1 613 ASN 613 876 876 ASN ASN A . n 
A 1 614 GLU 614 877 877 GLU GLU A . n 
A 1 615 GLU 615 878 878 GLU GLU A . n 
A 1 616 TYR 616 879 879 TYR TYR A . n 
A 1 617 THR 617 880 880 THR THR A . n 
A 1 618 ASP 618 881 881 ASP ASP A . n 
A 1 619 TYR 619 882 882 TYR TYR A . n 
A 1 620 MET 620 883 883 MET MET A . n 
A 1 621 PRO 621 884 884 PRO PRO A . n 
A 1 622 SER 622 885 885 SER SER A . n 
A 1 623 MET 623 886 886 MET MET A . n 
A 1 624 LYS 624 887 887 LYS LYS A . n 
A 1 625 ARG 625 888 888 ARG ARG A . n 
A 1 626 PHE 626 889 889 PHE PHE A . n 
A 1 627 ARG 627 890 890 ARG ARG A . n 
A 1 628 ARG 628 891 891 ARG ARG A . n 
A 1 629 GLU 629 892 ?   ?   ?   A . n 
A 1 630 GLU 630 893 ?   ?   ?   A . n 
A 1 631 GLU 631 894 ?   ?   ?   A . n 
A 1 632 GLU 632 895 ?   ?   ?   A . n 
A 1 633 ALA 633 896 ?   ?   ?   A . n 
A 1 634 GLY 634 897 ?   ?   ?   A . n 
A 1 635 VAL 635 898 ?   ?   ?   A . n 
A 1 636 LEU 636 899 ?   ?   ?   A . n 
A 1 637 TRP 637 900 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        LQI 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   LQI 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 ZN  1   1001 1001 ZN  ZN  A . 
C 2 ZN  1   1002 1002 ZN  ZN  A . 
D 3 MES 1   1003 1004 MES MES A . 
E 4 DMS 1   1004 1530 DMS DMS A . 
F 4 DMS 1   1005 1601 DMS DMS A . 
G 5 PO4 1   1006 1604 PO4 PO4 A . 
H 5 PO4 1   1007 1606 PO4 PO4 A . 
I 6 PEG 1   1008 1607 PEG PEG A . 
J 7 CL  1   1009 2001 CL  CL  A . 
K 8 LQI 1   1010 2101 LQI LIG A . 
L 9 HOH 1   1101 276  HOH HOH A . 
L 9 HOH 2   1102 341  HOH HOH A . 
L 9 HOH 3   1103 11   HOH HOH A . 
L 9 HOH 4   1104 195  HOH HOH A . 
L 9 HOH 5   1105 230  HOH HOH A . 
L 9 HOH 6   1106 174  HOH HOH A . 
L 9 HOH 7   1107 133  HOH HOH A . 
L 9 HOH 8   1108 70   HOH HOH A . 
L 9 HOH 9   1109 189  HOH HOH A . 
L 9 HOH 10  1110 209  HOH HOH A . 
L 9 HOH 11  1111 91   HOH HOH A . 
L 9 HOH 12  1112 178  HOH HOH A . 
L 9 HOH 13  1113 176  HOH HOH A . 
L 9 HOH 14  1114 90   HOH HOH A . 
L 9 HOH 15  1115 187  HOH HOH A . 
L 9 HOH 16  1116 52   HOH HOH A . 
L 9 HOH 17  1117 152  HOH HOH A . 
L 9 HOH 18  1118 227  HOH HOH A . 
L 9 HOH 19  1119 248  HOH HOH A . 
L 9 HOH 20  1120 311  HOH HOH A . 
L 9 HOH 21  1121 223  HOH HOH A . 
L 9 HOH 22  1122 206  HOH HOH A . 
L 9 HOH 23  1123 191  HOH HOH A . 
L 9 HOH 24  1124 37   HOH HOH A . 
L 9 HOH 25  1125 250  HOH HOH A . 
L 9 HOH 26  1126 460  HOH HOH A . 
L 9 HOH 27  1127 256  HOH HOH A . 
L 9 HOH 28  1128 92   HOH HOH A . 
L 9 HOH 29  1129 58   HOH HOH A . 
L 9 HOH 30  1130 336  HOH HOH A . 
L 9 HOH 31  1131 151  HOH HOH A . 
L 9 HOH 32  1132 220  HOH HOH A . 
L 9 HOH 33  1133 180  HOH HOH A . 
L 9 HOH 34  1134 251  HOH HOH A . 
L 9 HOH 35  1135 273  HOH HOH A . 
L 9 HOH 36  1136 281  HOH HOH A . 
L 9 HOH 37  1137 197  HOH HOH A . 
L 9 HOH 38  1138 112  HOH HOH A . 
L 9 HOH 39  1139 186  HOH HOH A . 
L 9 HOH 40  1140 205  HOH HOH A . 
L 9 HOH 41  1141 217  HOH HOH A . 
L 9 HOH 42  1142 348  HOH HOH A . 
L 9 HOH 43  1143 211  HOH HOH A . 
L 9 HOH 44  1144 325  HOH HOH A . 
L 9 HOH 45  1145 179  HOH HOH A . 
L 9 HOH 46  1146 303  HOH HOH A . 
L 9 HOH 47  1147 226  HOH HOH A . 
L 9 HOH 48  1148 392  HOH HOH A . 
L 9 HOH 49  1149 472  HOH HOH A . 
L 9 HOH 50  1150 190  HOH HOH A . 
L 9 HOH 51  1151 222  HOH HOH A . 
L 9 HOH 52  1152 395  HOH HOH A . 
L 9 HOH 53  1153 252  HOH HOH A . 
L 9 HOH 54  1154 294  HOH HOH A . 
L 9 HOH 55  1155 289  HOH HOH A . 
L 9 HOH 56  1156 262  HOH HOH A . 
L 9 HOH 57  1157 378  HOH HOH A . 
L 9 HOH 58  1158 258  HOH HOH A . 
L 9 HOH 59  1159 109  HOH HOH A . 
L 9 HOH 60  1160 306  HOH HOH A . 
L 9 HOH 61  1161 265  HOH HOH A . 
L 9 HOH 62  1162 363  HOH HOH A . 
L 9 HOH 63  1163 300  HOH HOH A . 
L 9 HOH 64  1164 184  HOH HOH A . 
L 9 HOH 65  1165 257  HOH HOH A . 
L 9 HOH 66  1166 215  HOH HOH A . 
L 9 HOH 67  1167 10   HOH HOH A . 
L 9 HOH 68  1168 185  HOH HOH A . 
L 9 HOH 69  1169 346  HOH HOH A . 
L 9 HOH 70  1170 89   HOH HOH A . 
L 9 HOH 71  1171 194  HOH HOH A . 
L 9 HOH 72  1172 331  HOH HOH A . 
L 9 HOH 73  1173 318  HOH HOH A . 
L 9 HOH 74  1174 188  HOH HOH A . 
L 9 HOH 75  1175 274  HOH HOH A . 
L 9 HOH 76  1176 2    HOH HOH A . 
L 9 HOH 77  1177 238  HOH HOH A . 
L 9 HOH 78  1178 333  HOH HOH A . 
L 9 HOH 79  1179 198  HOH HOH A . 
L 9 HOH 80  1180 278  HOH HOH A . 
L 9 HOH 81  1181 5    HOH HOH A . 
L 9 HOH 82  1182 309  HOH HOH A . 
L 9 HOH 83  1183 277  HOH HOH A . 
L 9 HOH 84  1184 210  HOH HOH A . 
L 9 HOH 85  1185 106  HOH HOH A . 
L 9 HOH 86  1186 269  HOH HOH A . 
L 9 HOH 87  1187 401  HOH HOH A . 
L 9 HOH 88  1188 196  HOH HOH A . 
L 9 HOH 89  1189 270  HOH HOH A . 
L 9 HOH 90  1190 308  HOH HOH A . 
L 9 HOH 91  1191 292  HOH HOH A . 
L 9 HOH 92  1192 207  HOH HOH A . 
L 9 HOH 93  1193 391  HOH HOH A . 
L 9 HOH 94  1194 312  HOH HOH A . 
L 9 HOH 95  1195 236  HOH HOH A . 
L 9 HOH 96  1196 201  HOH HOH A . 
L 9 HOH 97  1197 288  HOH HOH A . 
L 9 HOH 98  1198 244  HOH HOH A . 
L 9 HOH 99  1199 313  HOH HOH A . 
L 9 HOH 100 1200 290  HOH HOH A . 
L 9 HOH 101 1201 245  HOH HOH A . 
L 9 HOH 102 1202 255  HOH HOH A . 
L 9 HOH 103 1203 367  HOH HOH A . 
L 9 HOH 104 1204 264  HOH HOH A . 
L 9 HOH 105 1205 20   HOH HOH A . 
L 9 HOH 106 1206 372  HOH HOH A . 
L 9 HOH 107 1207 389  HOH HOH A . 
L 9 HOH 108 1208 199  HOH HOH A . 
L 9 HOH 109 1209 246  HOH HOH A . 
L 9 HOH 110 1210 423  HOH HOH A . 
L 9 HOH 111 1211 284  HOH HOH A . 
L 9 HOH 112 1212 345  HOH HOH A . 
L 9 HOH 113 1213 33   HOH HOH A . 
L 9 HOH 114 1214 234  HOH HOH A . 
L 9 HOH 115 1215 27   HOH HOH A . 
L 9 HOH 116 1216 144  HOH HOH A . 
L 9 HOH 117 1217 39   HOH HOH A . 
L 9 HOH 118 1218 86   HOH HOH A . 
L 9 HOH 119 1219 240  HOH HOH A . 
L 9 HOH 120 1220 4    HOH HOH A . 
L 9 HOH 121 1221 241  HOH HOH A . 
L 9 HOH 122 1222 365  HOH HOH A . 
L 9 HOH 123 1223 287  HOH HOH A . 
L 9 HOH 124 1224 350  HOH HOH A . 
L 9 HOH 125 1225 182  HOH HOH A . 
L 9 HOH 126 1226 285  HOH HOH A . 
L 9 HOH 127 1227 272  HOH HOH A . 
L 9 HOH 128 1228 298  HOH HOH A . 
L 9 HOH 129 1229 243  HOH HOH A . 
L 9 HOH 130 1230 314  HOH HOH A . 
L 9 HOH 131 1231 279  HOH HOH A . 
L 9 HOH 132 1232 213  HOH HOH A . 
L 9 HOH 133 1233 193  HOH HOH A . 
L 9 HOH 134 1234 233  HOH HOH A . 
L 9 HOH 135 1235 177  HOH HOH A . 
L 9 HOH 136 1236 326  HOH HOH A . 
L 9 HOH 137 1237 254  HOH HOH A . 
L 9 HOH 138 1238 295  HOH HOH A . 
L 9 HOH 139 1239 323  HOH HOH A . 
L 9 HOH 140 1240 355  HOH HOH A . 
L 9 HOH 141 1241 328  HOH HOH A . 
L 9 HOH 142 1242 3    HOH HOH A . 
L 9 HOH 143 1243 231  HOH HOH A . 
L 9 HOH 144 1244 140  HOH HOH A . 
L 9 HOH 145 1245 7    HOH HOH A . 
L 9 HOH 146 1246 45   HOH HOH A . 
L 9 HOH 147 1247 136  HOH HOH A . 
L 9 HOH 148 1248 316  HOH HOH A . 
L 9 HOH 149 1249 304  HOH HOH A . 
L 9 HOH 150 1250 282  HOH HOH A . 
L 9 HOH 151 1251 400  HOH HOH A . 
L 9 HOH 152 1252 321  HOH HOH A . 
L 9 HOH 153 1253 271  HOH HOH A . 
L 9 HOH 154 1254 335  HOH HOH A . 
L 9 HOH 155 1255 368  HOH HOH A . 
L 9 HOH 156 1256 260  HOH HOH A . 
L 9 HOH 157 1257 364  HOH HOH A . 
L 9 HOH 158 1258 404  HOH HOH A . 
L 9 HOH 159 1259 330  HOH HOH A . 
L 9 HOH 160 1260 127  HOH HOH A . 
L 9 HOH 161 1261 339  HOH HOH A . 
L 9 HOH 162 1262 369  HOH HOH A . 
L 9 HOH 163 1263 342  HOH HOH A . 
L 9 HOH 164 1264 357  HOH HOH A . 
L 9 HOH 165 1265 394  HOH HOH A . 
L 9 HOH 166 1266 30   HOH HOH A . 
L 9 HOH 167 1267 384  HOH HOH A . 
L 9 HOH 168 1268 322  HOH HOH A . 
L 9 HOH 169 1269 42   HOH HOH A . 
L 9 HOH 170 1270 388  HOH HOH A . 
L 9 HOH 171 1271 299  HOH HOH A . 
L 9 HOH 172 1272 344  HOH HOH A . 
L 9 HOH 173 1273 383  HOH HOH A . 
L 9 HOH 174 1274 18   HOH HOH A . 
L 9 HOH 175 1275 15   HOH HOH A . 
L 9 HOH 176 1276 228  HOH HOH A . 
L 9 HOH 177 1277 463  HOH HOH A . 
L 9 HOH 178 1278 114  HOH HOH A . 
L 9 HOH 179 1279 413  HOH HOH A . 
L 9 HOH 180 1280 366  HOH HOH A . 
L 9 HOH 181 1281 390  HOH HOH A . 
L 9 HOH 182 1282 297  HOH HOH A . 
L 9 HOH 183 1283 347  HOH HOH A . 
L 9 HOH 184 1284 203  HOH HOH A . 
L 9 HOH 185 1285 381  HOH HOH A . 
L 9 HOH 186 1286 380  HOH HOH A . 
L 9 HOH 187 1287 374  HOH HOH A . 
L 9 HOH 188 1288 354  HOH HOH A . 
L 9 HOH 189 1289 305  HOH HOH A . 
L 9 HOH 190 1290 352  HOH HOH A . 
L 9 HOH 191 1291 359  HOH HOH A . 
L 9 HOH 192 1292 261  HOH HOH A . 
L 9 HOH 193 1293 338  HOH HOH A . 
L 9 HOH 194 1294 62   HOH HOH A . 
L 9 HOH 195 1295 379  HOH HOH A . 
L 9 HOH 196 1296 361  HOH HOH A . 
L 9 HOH 197 1297 399  HOH HOH A . 
L 9 HOH 198 1298 67   HOH HOH A . 
L 9 HOH 199 1299 398  HOH HOH A . 
L 9 HOH 200 1300 387  HOH HOH A . 
L 9 HOH 201 1301 403  HOH HOH A . 
L 9 HOH 202 1302 416  HOH HOH A . 
L 9 HOH 203 1303 124  HOH HOH A . 
L 9 HOH 204 1304 465  HOH HOH A . 
L 9 HOH 205 1305 351  HOH HOH A . 
L 9 HOH 206 1306 14   HOH HOH A . 
L 9 HOH 207 1307 1    HOH HOH A . 
L 9 HOH 208 1308 411  HOH HOH A . 
L 9 HOH 209 1309 360  HOH HOH A . 
L 9 HOH 210 1310 332  HOH HOH A . 
L 9 HOH 211 1311 393  HOH HOH A . 
L 9 HOH 212 1312 410  HOH HOH A . 
L 9 HOH 213 1313 28   HOH HOH A . 
L 9 HOH 214 1314 406  HOH HOH A . 
L 9 HOH 215 1315 46   HOH HOH A . 
L 9 HOH 216 1316 340  HOH HOH A . 
L 9 HOH 217 1317 468  HOH HOH A . 
L 9 HOH 218 1318 56   HOH HOH A . 
L 9 HOH 219 1319 32   HOH HOH A . 
L 9 HOH 220 1320 329  HOH HOH A . 
L 9 HOH 221 1321 412  HOH HOH A . 
L 9 HOH 222 1322 334  HOH HOH A . 
L 9 HOH 223 1323 466  HOH HOH A . 
L 9 HOH 224 1324 38   HOH HOH A . 
L 9 HOH 225 1325 415  HOH HOH A . 
L 9 HOH 226 1326 200  HOH HOH A . 
L 9 HOH 227 1327 376  HOH HOH A . 
L 9 HOH 228 1328 373  HOH HOH A . 
L 9 HOH 229 1329 444  HOH HOH A . 
L 9 HOH 230 1330 424  HOH HOH A . 
L 9 HOH 231 1331 48   HOH HOH A . 
L 9 HOH 232 1332 422  HOH HOH A . 
L 9 HOH 233 1333 420  HOH HOH A . 
L 9 HOH 234 1334 132  HOH HOH A . 
L 9 HOH 235 1335 429  HOH HOH A . 
L 9 HOH 236 1336 68   HOH HOH A . 
L 9 HOH 237 1337 470  HOH HOH A . 
L 9 HOH 238 1338 439  HOH HOH A . 
L 9 HOH 239 1339 431  HOH HOH A . 
L 9 HOH 240 1340 40   HOH HOH A . 
L 9 HOH 241 1341 426  HOH HOH A . 
L 9 HOH 242 1342 239  HOH HOH A . 
L 9 HOH 243 1343 208  HOH HOH A . 
L 9 HOH 244 1344 409  HOH HOH A . 
L 9 HOH 245 1345 436  HOH HOH A . 
L 9 HOH 246 1346 75   HOH HOH A . 
L 9 HOH 247 1347 72   HOH HOH A . 
L 9 HOH 248 1348 428  HOH HOH A . 
L 9 HOH 249 1349 120  HOH HOH A . 
L 9 HOH 250 1350 301  HOH HOH A . 
L 9 HOH 251 1351 434  HOH HOH A . 
L 9 HOH 252 1352 473  HOH HOH A . 
L 9 HOH 253 1353 337  HOH HOH A . 
L 9 HOH 254 1354 438  HOH HOH A . 
L 9 HOH 255 1355 128  HOH HOH A . 
L 9 HOH 256 1356 471  HOH HOH A . 
L 9 HOH 257 1357 414  HOH HOH A . 
L 9 HOH 258 1358 97   HOH HOH A . 
L 9 HOH 259 1359 59   HOH HOH A . 
L 9 HOH 260 1360 442  HOH HOH A . 
L 9 HOH 261 1361 397  HOH HOH A . 
L 9 HOH 262 1362 437  HOH HOH A . 
L 9 HOH 263 1363 53   HOH HOH A . 
L 9 HOH 264 1364 430  HOH HOH A . 
L 9 HOH 265 1365 459  HOH HOH A . 
L 9 HOH 266 1366 435  HOH HOH A . 
L 9 HOH 267 1367 51   HOH HOH A . 
L 9 HOH 268 1368 425  HOH HOH A . 
L 9 HOH 269 1369 78   HOH HOH A . 
L 9 HOH 270 1370 407  HOH HOH A . 
L 9 HOH 271 1371 433  HOH HOH A . 
L 9 HOH 272 1372 443  HOH HOH A . 
L 9 HOH 273 1373 130  HOH HOH A . 
L 9 HOH 274 1374 61   HOH HOH A . 
L 9 HOH 275 1375 121  HOH HOH A . 
L 9 HOH 276 1376 47   HOH HOH A . 
L 9 HOH 277 1377 445  HOH HOH A . 
L 9 HOH 278 1378 74   HOH HOH A . 
L 9 HOH 279 1379 427  HOH HOH A . 
L 9 HOH 280 1380 467  HOH HOH A . 
L 9 HOH 281 1381 441  HOH HOH A . 
L 9 HOH 282 1382 8    HOH HOH A . 
L 9 HOH 283 1383 449  HOH HOH A . 
L 9 HOH 284 1384 64   HOH HOH A . 
L 9 HOH 285 1385 447  HOH HOH A . 
L 9 HOH 286 1386 440  HOH HOH A . 
L 9 HOH 287 1387 448  HOH HOH A . 
L 9 HOH 288 1388 9    HOH HOH A . 
L 9 HOH 289 1389 49   HOH HOH A . 
L 9 HOH 290 1390 95   HOH HOH A . 
L 9 HOH 291 1391 450  HOH HOH A . 
L 9 HOH 292 1392 73   HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A THR 344 ? CB  ? A THR 81 CB  
2 1 Y 1 A THR 344 ? OG1 ? A THR 81 OG1 
3 1 Y 1 A THR 344 ? CG2 ? A THR 81 CG2 
# 
loop_
_software.classification 
_software.name 
_software.version 
_software.citation_id 
_software.pdbx_ordinal 
_software.date 
_software.type 
_software.location 
_software.language 
refinement       REFMAC  5.8.0267 ? 1 ? ? ? ? 
'data scaling'   Aimless .        ? 2 ? ? ? ? 
phasing          PHASER  .        ? 3 ? ? ? ? 
'data reduction' XDS     .        ? 4 ? ? ? ? 
# 
_cell.entry_id           7I2U 
_cell.length_a           82.625 
_cell.length_b           115.814 
_cell.length_c           145.894 
_cell.angle_alpha        90.00 
_cell.angle_beta         90.00 
_cell.angle_gamma        90.00 
_cell.Z_PDB              8 
_cell.pdbx_unique_axis   ? 
# 
_symmetry.entry_id                         7I2U 
_symmetry.space_group_name_H-M             'I 2 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                23 
# 
_exptl.entry_id          7I2U 
_exptl.method            'X-RAY DIFFRACTION' 
_exptl.crystals_number   1 
# 
_exptl_crystal.id                    1 
_exptl_crystal.density_meas          ? 
_exptl_crystal.density_Matthews      2.36 
_exptl_crystal.density_percent_sol   47.92 
_exptl_crystal.description           ? 
_exptl_crystal.preparation           ? 
# 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.temp            293.15 
_exptl_crystal_grow.pdbx_details    '350 mM Magnesium chloride, 10% PEG 4000, 100 mM MES, pH 6.5' 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.pdbx_pH_range   ? 
# 
_diffrn.id                               1 
_diffrn.ambient_temp                     100 
_diffrn.crystal_id                       1 
_diffrn.ambient_temp_details             ? 
_diffrn.pdbx_serial_crystal_experiment   ? 
# 
_diffrn_detector.detector               PIXEL 
_diffrn_detector.type                   'DECTRIS EIGER2 XE 9M' 
_diffrn_detector.pdbx_collection_date   2023-12-05 
_diffrn_detector.diffrn_id              1 
_diffrn_detector.details                ? 
# 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.92124 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.diffrn_id                   1 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.type                        'DIAMOND BEAMLINE I04-1' 
_diffrn_source.pdbx_wavelength_list        0.92124 
_diffrn_source.pdbx_synchrotron_site       Diamond 
_diffrn_source.pdbx_synchrotron_beamline   I04-1 
_diffrn_source.pdbx_wavelength             ? 
# 
_reflns.entry_id                     7I2U 
_reflns.pdbx_diffrn_id               1 
_reflns.pdbx_ordinal                 1 
_reflns.d_resolution_low             49.45 
_reflns.d_resolution_high            1.96 
_reflns.number_obs                   50558 
_reflns.percent_possible_obs         100.0 
_reflns.pdbx_Rmerge_I_obs            0.232 
_reflns.pdbx_netI_over_sigmaI        7.3 
_reflns.pdbx_redundancy              13.7 
_reflns.pdbx_Rrim_I_all              0.241 
_reflns.pdbx_Rpim_I_all              0.065 
_reflns.pdbx_CC_half                 0.996 
_reflns.pdbx_number_measured_all     692445 
_reflns.pdbx_chi_squared             0.54 
_reflns.observed_criterion_sigma_I   ? 
_reflns.observed_criterion_sigma_F   ? 
_reflns.number_all                   ? 
_reflns.pdbx_Rsym_value              ? 
_reflns.B_iso_Wilson_estimate        ? 
_reflns.pdbx_CC_star                 ? 
# 
_reflns_shell.pdbx_diffrn_id              1 
_reflns_shell.pdbx_ordinal                1 
_reflns_shell.d_res_high                  1.96 
_reflns_shell.d_res_low                   2.01 
_reflns_shell.number_measured_all         45298 
_reflns_shell.number_unique_obs           3508 
_reflns_shell.Rmerge_I_obs                4.627 
_reflns_shell.pdbx_chi_squared            0.34 
_reflns_shell.pdbx_redundancy             12.9 
_reflns_shell.percent_possible_obs        99.5 
_reflns_shell.pdbx_netI_over_sigmaI_obs   0.4 
_reflns_shell.pdbx_Rrim_I_all             4.818 
_reflns_shell.pdbx_Rpim_I_all             1.332 
_reflns_shell.pdbx_CC_half                0.305 
_reflns_shell.percent_possible_all        ? 
_reflns_shell.pdbx_Rsym_value             ? 
_reflns_shell.meanI_over_sigI_obs         ? 
_reflns_shell.number_measured_obs         ? 
_reflns_shell.number_unique_all           ? 
_reflns_shell.pdbx_CC_star                ? 
# 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.entry_id                                 7I2U 
_refine.pdbx_diffrn_id                           1 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     47779 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             49.50 
_refine.ls_d_res_high                            1.96 
_refine.ls_percent_reflns_obs                    99.43 
_refine.ls_R_factor_obs                          0.19625 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       0.19379 
_refine.ls_R_factor_R_free                       0.24010 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 5.1 
_refine.ls_number_reflns_R_free                  2568 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               0.963 
_refine.correlation_coeff_Fo_to_Fc_free          0.943 
_refine.B_iso_mean                               64.102 
_refine.aniso_B[1][1]                            -2.98 
_refine.aniso_B[2][2]                            0.16 
_refine.aniso_B[3][3]                            2.82 
_refine.aniso_B[1][2]                            -0.00 
_refine.aniso_B[1][3]                            0.00 
_refine.aniso_B[2][3]                            -0.00 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_overall_ESU_R                       0.308 
_refine.pdbx_overall_ESU_R_Free                  0.203 
_refine.overall_SU_ML                            0.252 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             10.385 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.pdbx_number_atoms_protein        4767 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         58 
_refine_hist.number_atoms_solvent             292 
_refine_hist.number_atoms_total               5117 
_refine_hist.d_res_high                       1.96 
_refine_hist.d_res_low                        49.50 
# 
loop_
_refine_ls_restr.type 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.weight 
_refine_ls_restr.number 
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.pdbx_restraint_function 
r_bond_refined_d             0.007  0.014  ? 10584 'X-RAY DIFFRACTION' ? 
r_bond_other_d               0.001  0.015  ? 7648  'X-RAY DIFFRACTION' ? 
r_angle_refined_deg          1.418  1.644  ? 11187 'X-RAY DIFFRACTION' ? 
r_angle_other_deg            1.201  1.594  ? 17727 'X-RAY DIFFRACTION' ? 
r_dihedral_angle_1_deg       6.337  5.000  ? 1040  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_2_deg       30.589 21.355 ? 465   'X-RAY DIFFRACTION' ? 
r_dihedral_angle_3_deg       16.936 15.000 ? 1506  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_4_deg       16.882 15.000 ? 73    'X-RAY DIFFRACTION' ? 
r_chiral_restr               0.060  0.200  ? 1040  'X-RAY DIFFRACTION' ? 
r_gen_planes_refined         0.007  0.020  ? 9689  'X-RAY DIFFRACTION' ? 
r_gen_planes_other           0.001  0.020  ? 2013  'X-RAY DIFFRACTION' ? 
r_nbd_refined                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbd_other                  ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_refined              ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_other                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_refined        ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_other          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_refined          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_other            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_refined       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_other         ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_refined     ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_other       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_refined ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_other   ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_mcbond_it                  3.360  6.509  ? 5140  'X-RAY DIFFRACTION' ? 
r_mcbond_other               3.421  6.538  ? 4960  'X-RAY DIFFRACTION' ? 
r_mcangle_it                 6.009  9.387  ? 5034  'X-RAY DIFFRACTION' ? 
r_mcangle_other              6.010  9.389  ? 5033  'X-RAY DIFFRACTION' ? 
r_scbond_it                  3.810  7.330  ? 5444  'X-RAY DIFFRACTION' ? 
r_scbond_other               3.809  7.329  ? 5445  'X-RAY DIFFRACTION' ? 
r_scangle_it                 ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_scangle_other              6.354  10.432 ? 6154  'X-RAY DIFFRACTION' ? 
r_long_range_B_refined       10.107 56.236 ? 8124  'X-RAY DIFFRACTION' ? 
r_long_range_B_other         9.896  55.857 ? 7969  'X-RAY DIFFRACTION' ? 
r_rigid_bond_restr           ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_free            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_bonded          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.d_res_high                       1.959 
_refine_ls_shell.d_res_low                        2.009 
_refine_ls_shell.number_reflns_R_work             3226 
_refine_ls_shell.R_factor_R_work                  0.418 
_refine_ls_shell.percent_reflns_obs               93.02 
_refine_ls_shell.R_factor_R_free                  0.418 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.number_reflns_R_free             197 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.number_reflns_obs                ? 
# 
_struct.entry_id                  7I2U 
_struct.title                     
;Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z32665176 (DNV2_NS5A-x0787)
;
_struct.pdbx_model_details        ? 
_struct.pdbx_CASP_flag            ? 
_struct.pdbx_model_type_details   ? 
# 
_struct_keywords.entry_id        7I2U 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
_struct_keywords.text            
;Diamond Light Source, I04-1, READDI, Dengue Virus, crystallographic fragment screening, PanDDA, XChemExplorer, cluster4x, VIRAL PROTEIN
;
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 5 ? 
H N N 5 ? 
I N N 6 ? 
J N N 7 ? 
K N N 8 ? 
L N N 9 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q91H74_9FLAV 
_struct_ref.pdbx_db_accession          Q91H74 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;GIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAMTD
TTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAREA
VEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLS
GVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRPTP
RGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGDDC
VVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQGAG
WSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPWME
DKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_struct_ref.pdbx_align_begin           2757 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              7I2U 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 3 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 637 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q91H74 
_struct_ref_seq.db_align_beg                  2757 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3391 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       266 
_struct_ref_seq.pdbx_auth_seq_align_end       900 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 7I2U GLY A 1 ? UNP Q91H74 ? ? 'expression tag' 264 1 
1 7I2U PRO A 2 ? UNP Q91H74 ? ? 'expression tag' 265 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 10  ? HIS A 25  ? ASN A 273 HIS A 288 1 ? 16 
HELX_P HELX_P2  AA2 ASN A 59  ? LEU A 65  ? ASN A 322 LEU A 328 1 ? 7  
HELX_P HELX_P3  AA3 THR A 66  ? ILE A 71  ? THR A 329 ILE A 334 5 ? 6  
HELX_P HELX_P4  AA4 ILE A 72  ? GLN A 77  ? ILE A 335 GLN A 340 1 ? 6  
HELX_P HELX_P5  AA5 MET A 78  ? MET A 80  ? MET A 341 MET A 343 5 ? 3  
HELX_P HELX_P6  AA6 LYS A 104 ? LYS A 124 ? LYS A 367 LYS A 387 1 ? 21 
HELX_P HELX_P7  AA7 THR A 132 ? SER A 142 ? THR A 395 SER A 405 1 ? 11 
HELX_P HELX_P8  AA8 SER A 158 ? VAL A 163 ? SER A 421 VAL A 426 1 ? 6  
HELX_P HELX_P9  AA9 ASP A 165 ? GLU A 181 ? ASP A 428 GLU A 444 1 ? 17 
HELX_P HELX_P10 AB1 TRP A 215 ? GLY A 227 ? TRP A 478 GLY A 490 1 ? 13 
HELX_P HELX_P11 AB2 GLY A 227 ? ASP A 232 ? GLY A 490 ASP A 495 1 ? 6  
HELX_P HELX_P12 AB3 SER A 236 ? LEU A 241 ? SER A 499 LEU A 504 1 ? 6  
HELX_P HELX_P13 AB4 GLY A 248 ? LYS A 261 ? GLY A 511 LYS A 524 1 ? 14 
HELX_P HELX_P14 AB5 GLY A 274 ? ILE A 279 ? GLY A 537 ILE A 542 5 ? 6  
HELX_P HELX_P15 AB6 THR A 280 ? GLU A 288 ? THR A 543 GLU A 551 1 ? 9  
HELX_P HELX_P16 AB7 MET A 289 ? MET A 294 ? MET A 552 MET A 557 5 ? 6  
HELX_P HELX_P17 AB8 GLU A 295 ? THR A 309 ? GLU A 558 THR A 572 1 ? 15 
HELX_P HELX_P18 AB9 GLY A 339 ? GLU A 363 ? GLY A 602 GLU A 626 1 ? 25 
HELX_P HELX_P19 AC1 THR A 373 ? SER A 393 ? THR A 636 SER A 656 1 ? 21 
HELX_P HELX_P20 AC2 ASP A 408 ? ALA A 414 ? ASP A 671 ALA A 677 5 ? 7  
HELX_P HELX_P21 AC3 LEU A 415 ? MET A 421 ? LEU A 678 MET A 684 1 ? 7  
HELX_P HELX_P22 AC4 ASP A 439 ? VAL A 443 ? ASP A 702 VAL A 706 5 ? 5  
HELX_P HELX_P23 AC5 ASN A 467 ? ARG A 476 ? ASN A 730 ARG A 739 1 ? 10 
HELX_P HELX_P24 AC6 SER A 484 ? TYR A 503 ? SER A 747 TYR A 766 1 ? 20 
HELX_P HELX_P25 AC7 ARG A 506 ? VAL A 520 ? ARG A 769 VAL A 783 1 ? 15 
HELX_P HELX_P26 AC8 ASP A 545 ? ILE A 555 ? ASP A 808 ILE A 818 1 ? 11 
HELX_P HELX_P27 AC9 SER A 569 ? ILE A 573 ? SER A 832 ILE A 836 5 ? 5  
HELX_P HELX_P28 AD1 GLY A 577 ? CYS A 584 ? GLY A 840 CYS A 847 1 ? 8  
HELX_P HELX_P29 AD2 LEU A 590 ? ASN A 599 ? LEU A 853 ASN A 862 1 ? 10 
HELX_P HELX_P30 AD3 ASN A 599 ? GLY A 612 ? ASN A 862 GLY A 875 1 ? 14 
HELX_P HELX_P31 AD4 TYR A 619 ? ARG A 627 ? TYR A 882 ARG A 890 5 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A GLU 175 OE1 ? ? ? 1_555 C ZN . ZN ? ? A GLU 438 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.127 ? ? 
metalc2 metalc ? ? A HIS 179 NE2 ? ? ? 1_555 C ZN . ZN ? ? A HIS 442 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.212 ? ? 
metalc3 metalc ? ? A CYS 184 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 447 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.032 ? ? 
metalc4 metalc ? ? A CYS 187 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 450 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.290 ? ? 
metalc5 metalc ? ? A HIS 449 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 712 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.117 ? ? 
metalc6 metalc ? ? A HIS 451 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 714 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.018 ? ? 
metalc7 metalc ? ? A CYS 465 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 728 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.301 ? ? 
metalc8 metalc ? ? A CYS 584 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 847 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.314 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 NE2 ? A HIS 179 ? A HIS 442 ? 1_555 110.4 ? 
2  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 113.5 ? 
3  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 123.3 ? 
4  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 81.9  ? 
5  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 108.3 ? 
6  SG  ? A CYS 184 ? A CYS 447 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 111.6 ? 
7  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 101.2 ? 
8  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 106.7 ? 
9  NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 105.1 ? 
10 NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 103.5 ? 
11 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 119.9 ? 
12 SG  ? A CYS 465 ? A CYS 728 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 118.3 ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 41  ? GLU A 47  ? ALA A 304 GLU A 310 
AA1 2 VAL A 326 ? ARG A 332 ? VAL A 589 ARG A 595 
AA1 3 LYS A 313 ? ARG A 319 ? LYS A 576 ARG A 582 
AA1 4 TYR A 189 ? MET A 192 ? TYR A 452 MET A 455 
AA1 5 ILE A 211 ? TYR A 213 ? ILE A 474 TYR A 476 
AA2 1 MET A 57  ? VAL A 58  ? MET A 320 VAL A 321 
AA2 2 ILE A 477 ? SER A 478 ? ILE A 740 SER A 741 
AA3 1 MET A 395 ? SER A 398 ? MET A 658 SER A 661 
AA3 2 ASP A 401 ? VAL A 404 ? ASP A 664 VAL A 667 
AA4 1 HIS A 449 ? ILE A 454 ? HIS A 712 ILE A 717 
AA4 2 VAL A 460 ? CYS A 465 ? VAL A 723 CYS A 728 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N GLY A 44  ? N GLY A 307 O ILE A 329 ? O ILE A 592 
AA1 2 3 O VAL A 326 ? O VAL A 589 N ARG A 319 ? N ARG A 582 
AA1 3 4 O VAL A 314 ? O VAL A 577 N TYR A 189 ? N TYR A 452 
AA1 4 5 N ASN A 190 ? N ASN A 453 O TYR A 213 ? O TYR A 476 
AA2 1 2 N MET A 57  ? N MET A 320 O SER A 478 ? O SER A 741 
AA3 1 2 N SER A 398 ? N SER A 661 O ASP A 401 ? O ASP A 664 
AA4 1 2 N LEU A 453 ? N LEU A 716 O LEU A 461 ? O LEU A 724 
# 
_pdbx_entry_details.entry_id                   7I2U 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 OD1 A ASP 664 ? ? O4 A PO4 1006 ? ? 2.12 
2 1 OE1 A GLN 340 ? ? O  A HOH 1102 ? ? 2.18 
3 1 OD1 A ASP 534 ? ? O4 A PO4 1006 ? ? 2.19 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    HOH 
_pdbx_validate_symm_contact.auth_seq_id_1     1133 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    A 
_pdbx_validate_symm_contact.auth_comp_id_2    HOH 
_pdbx_validate_symm_contact.auth_seq_id_2     1133 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   2_445 
_pdbx_validate_symm_contact.dist              1.05 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASP A 297 ? ? -102.80 57.15   
2  1 PRO A 299 ? ? -74.24  25.09   
3  1 LYS A 358 ? ? -132.09 -43.85  
4  1 ASP A 360 ? ? -101.17 47.24   
5  1 PRO A 366 ? ? -46.81  154.92  
6  1 ASN A 406 ? ? 69.07   110.03  
7  1 ALA A 411 ? ? -104.92 -167.40 
8  1 LEU A 504 ? ? 74.39   -40.21  
9  1 VAL A 507 ? ? -140.40 18.09   
10 1 GLN A 598 ? ? 80.79   154.15  
11 1 ILE A 691 ? ? -174.23 145.50  
12 1 SER A 791 ? ? 64.87   -151.49 
13 1 ILE A 818 ? ? -120.34 -69.30  
14 1 ARG A 890 ? ? -69.51  66.45   
# 
loop_
_pdbx_validate_main_chain_plane.id 
_pdbx_validate_main_chain_plane.PDB_model_num 
_pdbx_validate_main_chain_plane.auth_comp_id 
_pdbx_validate_main_chain_plane.auth_asym_id 
_pdbx_validate_main_chain_plane.auth_seq_id 
_pdbx_validate_main_chain_plane.PDB_ins_code 
_pdbx_validate_main_chain_plane.label_alt_id 
_pdbx_validate_main_chain_plane.improper_torsion_angle 
1 1 PRO A 784 ? ? -10.44 
2 1 PRO A 784 ? ? -10.54 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A MES 1003 ? D MES . 
2 1 A HOH 1143 ? L HOH . 
3 1 A HOH 1243 ? L HOH . 
4 1 A HOH 1310 ? L HOH . 
5 1 A HOH 1354 ? L HOH . 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 1391 ? 6.24 . 
2 1 O ? A HOH 1392 ? 6.43 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 264 ? A GLY 1   
2  1 Y 1 A PRO 265 ? A PRO 2   
3  1 Y 1 A GLY 266 ? A GLY 3   
4  1 Y 1 A ILE 267 ? A ILE 4   
5  1 Y 1 A GLU 268 ? A GLU 5   
6  1 Y 1 A SER 269 ? A SER 6   
7  1 Y 1 A GLU 270 ? A GLU 7   
8  1 Y 1 A THR 271 ? A THR 8   
9  1 Y 1 A PRO 272 ? A PRO 9   
10 1 Y 1 A GLY 315 ? A GLY 52  
11 1 Y 1 A SER 316 ? A SER 53  
12 1 Y 1 A ASP 345 ? A ASP 82  
13 1 Y 1 A THR 346 ? A THR 83  
14 1 Y 1 A THR 347 ? A THR 84  
15 1 Y 1 A PRO 348 ? A PRO 85  
16 1 Y 1 A PHE 349 ? A PHE 86  
17 1 Y 1 A GLY 350 ? A GLY 87  
18 1 Y 1 A GLN 351 ? A GLN 88  
19 1 Y 1 A GLN 352 ? A GLN 89  
20 1 Y 1 A ARG 353 ? A ARG 90  
21 1 Y 1 A VAL 354 ? A VAL 91  
22 1 Y 1 A PHE 355 ? A PHE 92  
23 1 Y 1 A PHE 413 ? A PHE 150 
24 1 Y 1 A THR 414 ? A THR 151 
25 1 Y 1 A ASP 415 ? A ASP 152 
26 1 Y 1 A GLU 416 ? A GLU 153 
27 1 Y 1 A ASN 417 ? A ASN 154 
28 1 Y 1 A GLY 456 ? A GLY 193 
29 1 Y 1 A LYS 457 ? A LYS 194 
30 1 Y 1 A ARG 458 ? A ARG 195 
31 1 Y 1 A GLU 459 ? A GLU 196 
32 1 Y 1 A LYS 460 ? A LYS 197 
33 1 Y 1 A LYS 461 ? A LYS 198 
34 1 Y 1 A LEU 462 ? A LEU 199 
35 1 Y 1 A GLY 463 ? A GLY 200 
36 1 Y 1 A GLU 464 ? A GLU 201 
37 1 Y 1 A PHE 465 ? A PHE 202 
38 1 Y 1 A GLY 466 ? A GLY 203 
39 1 Y 1 A LYS 467 ? A LYS 204 
40 1 Y 1 A ALA 468 ? A ALA 205 
41 1 Y 1 A LYS 469 ? A LYS 206 
42 1 Y 1 A GLY 470 ? A GLY 207 
43 1 Y 1 A PRO 585 ? A PRO 322 
44 1 Y 1 A ARG 586 ? A ARG 323 
45 1 Y 1 A GLY 587 ? A GLY 324 
46 1 Y 1 A GLU 892 ? A GLU 629 
47 1 Y 1 A GLU 893 ? A GLU 630 
48 1 Y 1 A GLU 894 ? A GLU 631 
49 1 Y 1 A GLU 895 ? A GLU 632 
50 1 Y 1 A ALA 896 ? A ALA 633 
51 1 Y 1 A GLY 897 ? A GLY 634 
52 1 Y 1 A VAL 898 ? A VAL 635 
53 1 Y 1 A LEU 899 ? A LEU 636 
54 1 Y 1 A TRP 900 ? A TRP 637 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CL  CL   CL N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
DMS S    S  N N 89  
DMS O    O  N N 90  
DMS C1   C  N N 91  
DMS C2   C  N N 92  
DMS H11  H  N N 93  
DMS H12  H  N N 94  
DMS H13  H  N N 95  
DMS H21  H  N N 96  
DMS H22  H  N N 97  
DMS H23  H  N N 98  
GLN N    N  N N 99  
GLN CA   C  N S 100 
GLN C    C  N N 101 
GLN O    O  N N 102 
GLN CB   C  N N 103 
GLN CG   C  N N 104 
GLN CD   C  N N 105 
GLN OE1  O  N N 106 
GLN NE2  N  N N 107 
GLN OXT  O  N N 108 
GLN H    H  N N 109 
GLN H2   H  N N 110 
GLN HA   H  N N 111 
GLN HB2  H  N N 112 
GLN HB3  H  N N 113 
GLN HG2  H  N N 114 
GLN HG3  H  N N 115 
GLN HE21 H  N N 116 
GLN HE22 H  N N 117 
GLN HXT  H  N N 118 
GLU N    N  N N 119 
GLU CA   C  N S 120 
GLU C    C  N N 121 
GLU O    O  N N 122 
GLU CB   C  N N 123 
GLU CG   C  N N 124 
GLU CD   C  N N 125 
GLU OE1  O  N N 126 
GLU OE2  O  N N 127 
GLU OXT  O  N N 128 
GLU H    H  N N 129 
GLU H2   H  N N 130 
GLU HA   H  N N 131 
GLU HB2  H  N N 132 
GLU HB3  H  N N 133 
GLU HG2  H  N N 134 
GLU HG3  H  N N 135 
GLU HE2  H  N N 136 
GLU HXT  H  N N 137 
GLY N    N  N N 138 
GLY CA   C  N N 139 
GLY C    C  N N 140 
GLY O    O  N N 141 
GLY OXT  O  N N 142 
GLY H    H  N N 143 
GLY H2   H  N N 144 
GLY HA2  H  N N 145 
GLY HA3  H  N N 146 
GLY HXT  H  N N 147 
HIS N    N  N N 148 
HIS CA   C  N S 149 
HIS C    C  N N 150 
HIS O    O  N N 151 
HIS CB   C  N N 152 
HIS CG   C  Y N 153 
HIS ND1  N  Y N 154 
HIS CD2  C  Y N 155 
HIS CE1  C  Y N 156 
HIS NE2  N  Y N 157 
HIS OXT  O  N N 158 
HIS H    H  N N 159 
HIS H2   H  N N 160 
HIS HA   H  N N 161 
HIS HB2  H  N N 162 
HIS HB3  H  N N 163 
HIS HD1  H  N N 164 
HIS HD2  H  N N 165 
HIS HE1  H  N N 166 
HIS HE2  H  N N 167 
HIS HXT  H  N N 168 
HOH O    O  N N 169 
HOH H1   H  N N 170 
HOH H2   H  N N 171 
ILE N    N  N N 172 
ILE CA   C  N S 173 
ILE C    C  N N 174 
ILE O    O  N N 175 
ILE CB   C  N S 176 
ILE CG1  C  N N 177 
ILE CG2  C  N N 178 
ILE CD1  C  N N 179 
ILE OXT  O  N N 180 
ILE H    H  N N 181 
ILE H2   H  N N 182 
ILE HA   H  N N 183 
ILE HB   H  N N 184 
ILE HG12 H  N N 185 
ILE HG13 H  N N 186 
ILE HG21 H  N N 187 
ILE HG22 H  N N 188 
ILE HG23 H  N N 189 
ILE HD11 H  N N 190 
ILE HD12 H  N N 191 
ILE HD13 H  N N 192 
ILE HXT  H  N N 193 
LEU N    N  N N 194 
LEU CA   C  N S 195 
LEU C    C  N N 196 
LEU O    O  N N 197 
LEU CB   C  N N 198 
LEU CG   C  N N 199 
LEU CD1  C  N N 200 
LEU CD2  C  N N 201 
LEU OXT  O  N N 202 
LEU H    H  N N 203 
LEU H2   H  N N 204 
LEU HA   H  N N 205 
LEU HB2  H  N N 206 
LEU HB3  H  N N 207 
LEU HG   H  N N 208 
LEU HD11 H  N N 209 
LEU HD12 H  N N 210 
LEU HD13 H  N N 211 
LEU HD21 H  N N 212 
LEU HD22 H  N N 213 
LEU HD23 H  N N 214 
LEU HXT  H  N N 215 
LQI N1   N  N N 216 
LQI C4   C  N N 217 
LQI C5   C  N N 218 
LQI C6   C  N N 219 
LQI C7   C  N N 220 
LQI C8   C  Y N 221 
LQI C10  C  Y N 222 
LQI C13  C  Y N 223 
LQI C15  C  Y N 224 
LQI C1   C  N N 225 
LQI C2   C  N N 226 
LQI C3   C  N N 227 
LQI O1   O  N N 228 
LQI C9   C  Y N 229 
LQI C11  C  Y N 230 
LQI C12  C  Y N 231 
LQI C14  C  Y N 232 
LQI O2   O  Y N 233 
LQI H1   H  N N 234 
LQI H2   H  N N 235 
LQI H3   H  N N 236 
LQI H4   H  N N 237 
LQI H5   H  N N 238 
LQI H6   H  N N 239 
LQI H7   H  N N 240 
LQI H8   H  N N 241 
LQI H9   H  N N 242 
LQI H10  H  N N 243 
LQI H11  H  N N 244 
LQI H12  H  N N 245 
LQI H13  H  N N 246 
LQI H14  H  N N 247 
LQI H15  H  N N 248 
LQI H16  H  N N 249 
LQI H17  H  N N 250 
LYS N    N  N N 251 
LYS CA   C  N S 252 
LYS C    C  N N 253 
LYS O    O  N N 254 
LYS CB   C  N N 255 
LYS CG   C  N N 256 
LYS CD   C  N N 257 
LYS CE   C  N N 258 
LYS NZ   N  N N 259 
LYS OXT  O  N N 260 
LYS H    H  N N 261 
LYS H2   H  N N 262 
LYS HA   H  N N 263 
LYS HB2  H  N N 264 
LYS HB3  H  N N 265 
LYS HG2  H  N N 266 
LYS HG3  H  N N 267 
LYS HD2  H  N N 268 
LYS HD3  H  N N 269 
LYS HE2  H  N N 270 
LYS HE3  H  N N 271 
LYS HZ1  H  N N 272 
LYS HZ2  H  N N 273 
LYS HZ3  H  N N 274 
LYS HXT  H  N N 275 
MES O1   O  N N 276 
MES C2   C  N N 277 
MES C3   C  N N 278 
MES N4   N  N N 279 
MES C5   C  N N 280 
MES C6   C  N N 281 
MES C7   C  N N 282 
MES C8   C  N N 283 
MES S    S  N N 284 
MES O1S  O  N N 285 
MES O2S  O  N N 286 
MES O3S  O  N N 287 
MES H21  H  N N 288 
MES H22  H  N N 289 
MES H31  H  N N 290 
MES H32  H  N N 291 
MES HN4  H  N N 292 
MES H51  H  N N 293 
MES H52  H  N N 294 
MES H61  H  N N 295 
MES H62  H  N N 296 
MES H71  H  N N 297 
MES H72  H  N N 298 
MES H81  H  N N 299 
MES H82  H  N N 300 
MET N    N  N N 301 
MET CA   C  N S 302 
MET C    C  N N 303 
MET O    O  N N 304 
MET CB   C  N N 305 
MET CG   C  N N 306 
MET SD   S  N N 307 
MET CE   C  N N 308 
MET OXT  O  N N 309 
MET H    H  N N 310 
MET H2   H  N N 311 
MET HA   H  N N 312 
MET HB2  H  N N 313 
MET HB3  H  N N 314 
MET HG2  H  N N 315 
MET HG3  H  N N 316 
MET HE1  H  N N 317 
MET HE2  H  N N 318 
MET HE3  H  N N 319 
MET HXT  H  N N 320 
PEG C1   C  N N 321 
PEG O1   O  N N 322 
PEG C2   C  N N 323 
PEG O2   O  N N 324 
PEG C3   C  N N 325 
PEG C4   C  N N 326 
PEG O4   O  N N 327 
PEG H11  H  N N 328 
PEG H12  H  N N 329 
PEG HO1  H  N N 330 
PEG H21  H  N N 331 
PEG H22  H  N N 332 
PEG H31  H  N N 333 
PEG H32  H  N N 334 
PEG H41  H  N N 335 
PEG H42  H  N N 336 
PEG HO4  H  N N 337 
PHE N    N  N N 338 
PHE CA   C  N S 339 
PHE C    C  N N 340 
PHE O    O  N N 341 
PHE CB   C  N N 342 
PHE CG   C  Y N 343 
PHE CD1  C  Y N 344 
PHE CD2  C  Y N 345 
PHE CE1  C  Y N 346 
PHE CE2  C  Y N 347 
PHE CZ   C  Y N 348 
PHE OXT  O  N N 349 
PHE H    H  N N 350 
PHE H2   H  N N 351 
PHE HA   H  N N 352 
PHE HB2  H  N N 353 
PHE HB3  H  N N 354 
PHE HD1  H  N N 355 
PHE HD2  H  N N 356 
PHE HE1  H  N N 357 
PHE HE2  H  N N 358 
PHE HZ   H  N N 359 
PHE HXT  H  N N 360 
PO4 P    P  N N 361 
PO4 O1   O  N N 362 
PO4 O2   O  N N 363 
PO4 O3   O  N N 364 
PO4 O4   O  N N 365 
PRO N    N  N N 366 
PRO CA   C  N S 367 
PRO C    C  N N 368 
PRO O    O  N N 369 
PRO CB   C  N N 370 
PRO CG   C  N N 371 
PRO CD   C  N N 372 
PRO OXT  O  N N 373 
PRO H    H  N N 374 
PRO HA   H  N N 375 
PRO HB2  H  N N 376 
PRO HB3  H  N N 377 
PRO HG2  H  N N 378 
PRO HG3  H  N N 379 
PRO HD2  H  N N 380 
PRO HD3  H  N N 381 
PRO HXT  H  N N 382 
SER N    N  N N 383 
SER CA   C  N S 384 
SER C    C  N N 385 
SER O    O  N N 386 
SER CB   C  N N 387 
SER OG   O  N N 388 
SER OXT  O  N N 389 
SER H    H  N N 390 
SER H2   H  N N 391 
SER HA   H  N N 392 
SER HB2  H  N N 393 
SER HB3  H  N N 394 
SER HG   H  N N 395 
SER HXT  H  N N 396 
THR N    N  N N 397 
THR CA   C  N S 398 
THR C    C  N N 399 
THR O    O  N N 400 
THR CB   C  N R 401 
THR OG1  O  N N 402 
THR CG2  C  N N 403 
THR OXT  O  N N 404 
THR H    H  N N 405 
THR H2   H  N N 406 
THR HA   H  N N 407 
THR HB   H  N N 408 
THR HG1  H  N N 409 
THR HG21 H  N N 410 
THR HG22 H  N N 411 
THR HG23 H  N N 412 
THR HXT  H  N N 413 
TRP N    N  N N 414 
TRP CA   C  N S 415 
TRP C    C  N N 416 
TRP O    O  N N 417 
TRP CB   C  N N 418 
TRP CG   C  Y N 419 
TRP CD1  C  Y N 420 
TRP CD2  C  Y N 421 
TRP NE1  N  Y N 422 
TRP CE2  C  Y N 423 
TRP CE3  C  Y N 424 
TRP CZ2  C  Y N 425 
TRP CZ3  C  Y N 426 
TRP CH2  C  Y N 427 
TRP OXT  O  N N 428 
TRP H    H  N N 429 
TRP H2   H  N N 430 
TRP HA   H  N N 431 
TRP HB2  H  N N 432 
TRP HB3  H  N N 433 
TRP HD1  H  N N 434 
TRP HE1  H  N N 435 
TRP HE3  H  N N 436 
TRP HZ2  H  N N 437 
TRP HZ3  H  N N 438 
TRP HH2  H  N N 439 
TRP HXT  H  N N 440 
TYR N    N  N N 441 
TYR CA   C  N S 442 
TYR C    C  N N 443 
TYR O    O  N N 444 
TYR CB   C  N N 445 
TYR CG   C  Y N 446 
TYR CD1  C  Y N 447 
TYR CD2  C  Y N 448 
TYR CE1  C  Y N 449 
TYR CE2  C  Y N 450 
TYR CZ   C  Y N 451 
TYR OH   O  N N 452 
TYR OXT  O  N N 453 
TYR H    H  N N 454 
TYR H2   H  N N 455 
TYR HA   H  N N 456 
TYR HB2  H  N N 457 
TYR HB3  H  N N 458 
TYR HD1  H  N N 459 
TYR HD2  H  N N 460 
TYR HE1  H  N N 461 
TYR HE2  H  N N 462 
TYR HH   H  N N 463 
TYR HXT  H  N N 464 
VAL N    N  N N 465 
VAL CA   C  N S 466 
VAL C    C  N N 467 
VAL O    O  N N 468 
VAL CB   C  N N 469 
VAL CG1  C  N N 470 
VAL CG2  C  N N 471 
VAL OXT  O  N N 472 
VAL H    H  N N 473 
VAL H2   H  N N 474 
VAL HA   H  N N 475 
VAL HB   H  N N 476 
VAL HG11 H  N N 477 
VAL HG12 H  N N 478 
VAL HG13 H  N N 479 
VAL HG21 H  N N 480 
VAL HG22 H  N N 481 
VAL HG23 H  N N 482 
VAL HXT  H  N N 483 
ZN  ZN   ZN N N 484 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
DMS S   O    doub N N 83  
DMS S   C1   sing N N 84  
DMS S   C2   sing N N 85  
DMS C1  H11  sing N N 86  
DMS C1  H12  sing N N 87  
DMS C1  H13  sing N N 88  
DMS C2  H21  sing N N 89  
DMS C2  H22  sing N N 90  
DMS C2  H23  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
HIS N   CA   sing N N 138 
HIS N   H    sing N N 139 
HIS N   H2   sing N N 140 
HIS CA  C    sing N N 141 
HIS CA  CB   sing N N 142 
HIS CA  HA   sing N N 143 
HIS C   O    doub N N 144 
HIS C   OXT  sing N N 145 
HIS CB  CG   sing N N 146 
HIS CB  HB2  sing N N 147 
HIS CB  HB3  sing N N 148 
HIS CG  ND1  sing Y N 149 
HIS CG  CD2  doub Y N 150 
HIS ND1 CE1  doub Y N 151 
HIS ND1 HD1  sing N N 152 
HIS CD2 NE2  sing Y N 153 
HIS CD2 HD2  sing N N 154 
HIS CE1 NE2  sing Y N 155 
HIS CE1 HE1  sing N N 156 
HIS NE2 HE2  sing N N 157 
HIS OXT HXT  sing N N 158 
HOH O   H1   sing N N 159 
HOH O   H2   sing N N 160 
ILE N   CA   sing N N 161 
ILE N   H    sing N N 162 
ILE N   H2   sing N N 163 
ILE CA  C    sing N N 164 
ILE CA  CB   sing N N 165 
ILE CA  HA   sing N N 166 
ILE C   O    doub N N 167 
ILE C   OXT  sing N N 168 
ILE CB  CG1  sing N N 169 
ILE CB  CG2  sing N N 170 
ILE CB  HB   sing N N 171 
ILE CG1 CD1  sing N N 172 
ILE CG1 HG12 sing N N 173 
ILE CG1 HG13 sing N N 174 
ILE CG2 HG21 sing N N 175 
ILE CG2 HG22 sing N N 176 
ILE CG2 HG23 sing N N 177 
ILE CD1 HD11 sing N N 178 
ILE CD1 HD12 sing N N 179 
ILE CD1 HD13 sing N N 180 
ILE OXT HXT  sing N N 181 
LEU N   CA   sing N N 182 
LEU N   H    sing N N 183 
LEU N   H2   sing N N 184 
LEU CA  C    sing N N 185 
LEU CA  CB   sing N N 186 
LEU CA  HA   sing N N 187 
LEU C   O    doub N N 188 
LEU C   OXT  sing N N 189 
LEU CB  CG   sing N N 190 
LEU CB  HB2  sing N N 191 
LEU CB  HB3  sing N N 192 
LEU CG  CD1  sing N N 193 
LEU CG  CD2  sing N N 194 
LEU CG  HG   sing N N 195 
LEU CD1 HD11 sing N N 196 
LEU CD1 HD12 sing N N 197 
LEU CD1 HD13 sing N N 198 
LEU CD2 HD21 sing N N 199 
LEU CD2 HD22 sing N N 200 
LEU CD2 HD23 sing N N 201 
LEU OXT HXT  sing N N 202 
LQI C5  C6   sing N N 203 
LQI C5  N1   sing N N 204 
LQI C6  C2   sing N N 205 
LQI O1  C7   doub N N 206 
LQI C2  C1   sing N N 207 
LQI C2  C3   sing N N 208 
LQI C7  N1   sing N N 209 
LQI C7  C8   sing N N 210 
LQI N1  C4   sing N N 211 
LQI O2  C8   sing Y N 212 
LQI O2  C15  sing Y N 213 
LQI C3  C4   sing N N 214 
LQI C8  C9   doub Y N 215 
LQI C15 C14  doub Y N 216 
LQI C15 C10  sing Y N 217 
LQI C9  C10  sing Y N 218 
LQI C14 C13  sing Y N 219 
LQI C10 C11  doub Y N 220 
LQI C13 C12  doub Y N 221 
LQI C11 C12  sing Y N 222 
LQI C4  H1   sing N N 223 
LQI C4  H2   sing N N 224 
LQI C5  H3   sing N N 225 
LQI C5  H4   sing N N 226 
LQI C6  H5   sing N N 227 
LQI C6  H6   sing N N 228 
LQI C13 H7   sing N N 229 
LQI C1  H8   sing N N 230 
LQI C1  H9   sing N N 231 
LQI C1  H10  sing N N 232 
LQI C2  H11  sing N N 233 
LQI C3  H12  sing N N 234 
LQI C3  H13  sing N N 235 
LQI C9  H14  sing N N 236 
LQI C11 H15  sing N N 237 
LQI C12 H16  sing N N 238 
LQI C14 H17  sing N N 239 
LYS N   CA   sing N N 240 
LYS N   H    sing N N 241 
LYS N   H2   sing N N 242 
LYS CA  C    sing N N 243 
LYS CA  CB   sing N N 244 
LYS CA  HA   sing N N 245 
LYS C   O    doub N N 246 
LYS C   OXT  sing N N 247 
LYS CB  CG   sing N N 248 
LYS CB  HB2  sing N N 249 
LYS CB  HB3  sing N N 250 
LYS CG  CD   sing N N 251 
LYS CG  HG2  sing N N 252 
LYS CG  HG3  sing N N 253 
LYS CD  CE   sing N N 254 
LYS CD  HD2  sing N N 255 
LYS CD  HD3  sing N N 256 
LYS CE  NZ   sing N N 257 
LYS CE  HE2  sing N N 258 
LYS CE  HE3  sing N N 259 
LYS NZ  HZ1  sing N N 260 
LYS NZ  HZ2  sing N N 261 
LYS NZ  HZ3  sing N N 262 
LYS OXT HXT  sing N N 263 
MES O1  C2   sing N N 264 
MES O1  C6   sing N N 265 
MES C2  C3   sing N N 266 
MES C2  H21  sing N N 267 
MES C2  H22  sing N N 268 
MES C3  N4   sing N N 269 
MES C3  H31  sing N N 270 
MES C3  H32  sing N N 271 
MES N4  C5   sing N N 272 
MES N4  C7   sing N N 273 
MES N4  HN4  sing N N 274 
MES C5  C6   sing N N 275 
MES C5  H51  sing N N 276 
MES C5  H52  sing N N 277 
MES C6  H61  sing N N 278 
MES C6  H62  sing N N 279 
MES C7  C8   sing N N 280 
MES C7  H71  sing N N 281 
MES C7  H72  sing N N 282 
MES C8  S    sing N N 283 
MES C8  H81  sing N N 284 
MES C8  H82  sing N N 285 
MES S   O1S  doub N N 286 
MES S   O2S  doub N N 287 
MES S   O3S  sing N N 288 
MET N   CA   sing N N 289 
MET N   H    sing N N 290 
MET N   H2   sing N N 291 
MET CA  C    sing N N 292 
MET CA  CB   sing N N 293 
MET CA  HA   sing N N 294 
MET C   O    doub N N 295 
MET C   OXT  sing N N 296 
MET CB  CG   sing N N 297 
MET CB  HB2  sing N N 298 
MET CB  HB3  sing N N 299 
MET CG  SD   sing N N 300 
MET CG  HG2  sing N N 301 
MET CG  HG3  sing N N 302 
MET SD  CE   sing N N 303 
MET CE  HE1  sing N N 304 
MET CE  HE2  sing N N 305 
MET CE  HE3  sing N N 306 
MET OXT HXT  sing N N 307 
PEG C1  O1   sing N N 308 
PEG C1  C2   sing N N 309 
PEG C1  H11  sing N N 310 
PEG C1  H12  sing N N 311 
PEG O1  HO1  sing N N 312 
PEG C2  O2   sing N N 313 
PEG C2  H21  sing N N 314 
PEG C2  H22  sing N N 315 
PEG O2  C3   sing N N 316 
PEG C3  C4   sing N N 317 
PEG C3  H31  sing N N 318 
PEG C3  H32  sing N N 319 
PEG C4  O4   sing N N 320 
PEG C4  H41  sing N N 321 
PEG C4  H42  sing N N 322 
PEG O4  HO4  sing N N 323 
PHE N   CA   sing N N 324 
PHE N   H    sing N N 325 
PHE N   H2   sing N N 326 
PHE CA  C    sing N N 327 
PHE CA  CB   sing N N 328 
PHE CA  HA   sing N N 329 
PHE C   O    doub N N 330 
PHE C   OXT  sing N N 331 
PHE CB  CG   sing N N 332 
PHE CB  HB2  sing N N 333 
PHE CB  HB3  sing N N 334 
PHE CG  CD1  doub Y N 335 
PHE CG  CD2  sing Y N 336 
PHE CD1 CE1  sing Y N 337 
PHE CD1 HD1  sing N N 338 
PHE CD2 CE2  doub Y N 339 
PHE CD2 HD2  sing N N 340 
PHE CE1 CZ   doub Y N 341 
PHE CE1 HE1  sing N N 342 
PHE CE2 CZ   sing Y N 343 
PHE CE2 HE2  sing N N 344 
PHE CZ  HZ   sing N N 345 
PHE OXT HXT  sing N N 346 
PO4 P   O1   doub N N 347 
PO4 P   O2   sing N N 348 
PO4 P   O3   sing N N 349 
PO4 P   O4   sing N N 350 
PRO N   CA   sing N N 351 
PRO N   CD   sing N N 352 
PRO N   H    sing N N 353 
PRO CA  C    sing N N 354 
PRO CA  CB   sing N N 355 
PRO CA  HA   sing N N 356 
PRO C   O    doub N N 357 
PRO C   OXT  sing N N 358 
PRO CB  CG   sing N N 359 
PRO CB  HB2  sing N N 360 
PRO CB  HB3  sing N N 361 
PRO CG  CD   sing N N 362 
PRO CG  HG2  sing N N 363 
PRO CG  HG3  sing N N 364 
PRO CD  HD2  sing N N 365 
PRO CD  HD3  sing N N 366 
PRO OXT HXT  sing N N 367 
SER N   CA   sing N N 368 
SER N   H    sing N N 369 
SER N   H2   sing N N 370 
SER CA  C    sing N N 371 
SER CA  CB   sing N N 372 
SER CA  HA   sing N N 373 
SER C   O    doub N N 374 
SER C   OXT  sing N N 375 
SER CB  OG   sing N N 376 
SER CB  HB2  sing N N 377 
SER CB  HB3  sing N N 378 
SER OG  HG   sing N N 379 
SER OXT HXT  sing N N 380 
THR N   CA   sing N N 381 
THR N   H    sing N N 382 
THR N   H2   sing N N 383 
THR CA  C    sing N N 384 
THR CA  CB   sing N N 385 
THR CA  HA   sing N N 386 
THR C   O    doub N N 387 
THR C   OXT  sing N N 388 
THR CB  OG1  sing N N 389 
THR CB  CG2  sing N N 390 
THR CB  HB   sing N N 391 
THR OG1 HG1  sing N N 392 
THR CG2 HG21 sing N N 393 
THR CG2 HG22 sing N N 394 
THR CG2 HG23 sing N N 395 
THR OXT HXT  sing N N 396 
TRP N   CA   sing N N 397 
TRP N   H    sing N N 398 
TRP N   H2   sing N N 399 
TRP CA  C    sing N N 400 
TRP CA  CB   sing N N 401 
TRP CA  HA   sing N N 402 
TRP C   O    doub N N 403 
TRP C   OXT  sing N N 404 
TRP CB  CG   sing N N 405 
TRP CB  HB2  sing N N 406 
TRP CB  HB3  sing N N 407 
TRP CG  CD1  doub Y N 408 
TRP CG  CD2  sing Y N 409 
TRP CD1 NE1  sing Y N 410 
TRP CD1 HD1  sing N N 411 
TRP CD2 CE2  doub Y N 412 
TRP CD2 CE3  sing Y N 413 
TRP NE1 CE2  sing Y N 414 
TRP NE1 HE1  sing N N 415 
TRP CE2 CZ2  sing Y N 416 
TRP CE3 CZ3  doub Y N 417 
TRP CE3 HE3  sing N N 418 
TRP CZ2 CH2  doub Y N 419 
TRP CZ2 HZ2  sing N N 420 
TRP CZ3 CH2  sing Y N 421 
TRP CZ3 HZ3  sing N N 422 
TRP CH2 HH2  sing N N 423 
TRP OXT HXT  sing N N 424 
TYR N   CA   sing N N 425 
TYR N   H    sing N N 426 
TYR N   H2   sing N N 427 
TYR CA  C    sing N N 428 
TYR CA  CB   sing N N 429 
TYR CA  HA   sing N N 430 
TYR C   O    doub N N 431 
TYR C   OXT  sing N N 432 
TYR CB  CG   sing N N 433 
TYR CB  HB2  sing N N 434 
TYR CB  HB3  sing N N 435 
TYR CG  CD1  doub Y N 436 
TYR CG  CD2  sing Y N 437 
TYR CD1 CE1  sing Y N 438 
TYR CD1 HD1  sing N N 439 
TYR CD2 CE2  doub Y N 440 
TYR CD2 HD2  sing N N 441 
TYR CE1 CZ   doub Y N 442 
TYR CE1 HE1  sing N N 443 
TYR CE2 CZ   sing Y N 444 
TYR CE2 HE2  sing N N 445 
TYR CZ  OH   sing N N 446 
TYR OH  HH   sing N N 447 
TYR OXT HXT  sing N N 448 
VAL N   CA   sing N N 449 
VAL N   H    sing N N 450 
VAL N   H2   sing N N 451 
VAL CA  C    sing N N 452 
VAL CA  CB   sing N N 453 
VAL CA  HA   sing N N 454 
VAL C   O    doub N N 455 
VAL C   OXT  sing N N 456 
VAL CB  CG1  sing N N 457 
VAL CB  CG2  sing N N 458 
VAL CB  HB   sing N N 459 
VAL CG1 HG11 sing N N 460 
VAL CG1 HG12 sing N N 461 
VAL CG1 HG13 sing N N 462 
VAL CG2 HG21 sing N N 463 
VAL CG2 HG22 sing N N 464 
VAL CG2 HG23 sing N N 465 
VAL OXT HXT  sing N N 466 
# 
_pdbx_audit_support.ordinal                1 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)' 
_pdbx_audit_support.grant_number           U19AI171292 
_pdbx_audit_support.country                'United States' 
# 
_pdbx_deposit_group.group_id            G_1002341 
_pdbx_deposit_group.group_description   
'Crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_title         
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_type          'changed state' 
# 
_atom_sites.entry_id                    7I2U 
_atom_sites.fract_transf_matrix[1][1]   0.012103 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.008635 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006854 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
# 
loop_
_atom_type.symbol 
C  
CL 
N  
O  
P  
S  
ZN 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ASN A 1 10  ? -14.105 -5.764  -11.313 0.50 107.26 ? 273  ASN A N   1 
ATOM   2    C  CA  . ASN A 1 10  ? -13.846 -6.580  -10.091 0.50 107.13 ? 273  ASN A CA  1 
ATOM   3    C  C   . ASN A 1 10  ? -15.138 -6.653  -9.268  0.50 108.18 ? 273  ASN A C   1 
ATOM   4    O  O   . ASN A 1 10  ? -16.098 -7.303  -9.736  0.50 105.86 ? 273  ASN A O   1 
ATOM   5    C  CB  . ASN A 1 10  ? -12.675 -6.022  -9.275  0.50 109.07 ? 273  ASN A CB  1 
ATOM   6    C  CG  . ASN A 1 10  ? -12.122 -7.009  -8.266  0.50 109.44 ? 273  ASN A CG  1 
ATOM   7    O  OD1 . ASN A 1 10  ? -12.789 -7.975  -7.904  0.50 109.86 ? 273  ASN A OD1 1 
ATOM   8    N  ND2 . ASN A 1 10  ? -10.902 -6.779  -7.806  0.50 107.56 ? 273  ASN A ND2 1 
ATOM   9    N  N   . LEU A 1 11  ? -15.162 -6.000  -8.100  0.50 105.78 ? 274  LEU A N   1 
ATOM   10   C  CA  . LEU A 1 11  ? -16.289 -6.064  -7.129  0.50 101.61 ? 274  LEU A CA  1 
ATOM   11   C  C   . LEU A 1 11  ? -17.537 -5.434  -7.753  0.50 98.28  ? 274  LEU A C   1 
ATOM   12   O  O   . LEU A 1 11  ? -18.632 -5.609  -7.188  0.50 96.33  ? 274  LEU A O   1 
ATOM   13   C  CB  . LEU A 1 11  ? -15.900 -5.349  -5.831  0.50 101.40 ? 274  LEU A CB  1 
ATOM   14   C  CG  . LEU A 1 11  ? -14.963 -6.128  -4.910  0.50 102.15 ? 274  LEU A CG  1 
ATOM   15   C  CD1 . LEU A 1 11  ? -13.513 -5.716  -5.135  0.50 100.21 ? 274  LEU A CD1 1 
ATOM   16   C  CD2 . LEU A 1 11  ? -15.354 -5.938  -3.451  0.50 100.79 ? 274  LEU A CD2 1 
ATOM   17   N  N   . ASP A 1 12  ? -17.373 -4.728  -8.874  0.50 94.93  ? 275  ASP A N   1 
ATOM   18   C  CA  . ASP A 1 12  ? -18.496 -4.141  -9.650  0.50 97.77  ? 275  ASP A CA  1 
ATOM   19   C  C   . ASP A 1 12  ? -19.316 -5.282  -10.259 0.50 95.05  ? 275  ASP A C   1 
ATOM   20   O  O   . ASP A 1 12  ? -20.540 -5.105  -10.426 0.50 98.22  ? 275  ASP A O   1 
ATOM   21   C  CB  . ASP A 1 12  ? -17.983 -3.181  -10.725 0.50 102.35 ? 275  ASP A CB  1 
ATOM   22   C  CG  . ASP A 1 12  ? -16.862 -3.763  -11.568 0.50 106.82 ? 275  ASP A CG  1 
ATOM   23   O  OD1 . ASP A 1 12  ? -16.237 -4.748  -11.117 0.50 103.63 ? 275  ASP A OD1 1 
ATOM   24   O  OD2 . ASP A 1 12  ? -16.628 -3.231  -12.673 0.50 111.54 ? 275  ASP A OD2 1 
ATOM   25   N  N   . ILE A 1 13  ? -18.662 -6.410  -10.562 0.50 88.10  ? 276  ILE A N   1 
ATOM   26   C  CA  . ILE A 1 13  ? -19.273 -7.591  -11.243 0.50 78.92  ? 276  ILE A CA  1 
ATOM   27   C  C   . ILE A 1 13  ? -19.617 -8.662  -10.201 0.50 74.79  ? 276  ILE A C   1 
ATOM   28   O  O   . ILE A 1 13  ? -20.645 -9.338  -10.372 0.50 72.67  ? 276  ILE A O   1 
ATOM   29   C  CB  . ILE A 1 13  ? -18.334 -8.131  -12.339 0.50 75.96  ? 276  ILE A CB  1 
ATOM   30   C  CG1 . ILE A 1 13  ? -18.139 -7.105  -13.459 0.50 71.92  ? 276  ILE A CG1 1 
ATOM   31   C  CG2 . ILE A 1 13  ? -18.839 -9.463  -12.868 0.50 76.03  ? 276  ILE A CG2 1 
ATOM   32   C  CD1 . ILE A 1 13  ? -17.291 -7.593  -14.605 0.50 70.84  ? 276  ILE A CD1 1 
ATOM   33   N  N   . ILE A 1 14  ? -18.800 -8.798  -9.155  0.50 73.98  ? 277  ILE A N   1 
ATOM   34   C  CA  . ILE A 1 14  ? -18.940 -9.870  -8.124  0.50 75.16  ? 277  ILE A CA  1 
ATOM   35   C  C   . ILE A 1 14  ? -19.594 -9.285  -6.867  0.50 74.35  ? 277  ILE A C   1 
ATOM   36   O  O   . ILE A 1 14  ? -20.202 -10.062 -6.105  0.50 73.10  ? 277  ILE A O   1 
ATOM   37   C  CB  . ILE A 1 14  ? -17.567 -10.499 -7.821  0.50 76.41  ? 277  ILE A CB  1 
ATOM   38   C  CG1 . ILE A 1 14  ? -16.575 -9.457  -7.300  0.50 77.84  ? 277  ILE A CG1 1 
ATOM   39   C  CG2 . ILE A 1 14  ? -17.029 -11.223 -9.046  0.50 75.78  ? 277  ILE A CG2 1 
ATOM   40   C  CD1 . ILE A 1 14  ? -15.187 -9.999  -7.063  0.50 79.40  ? 277  ILE A CD1 1 
ATOM   41   N  N   . GLY A 1 15  ? -19.477 -7.966  -6.679  0.50 78.43  ? 278  GLY A N   1 
ATOM   42   C  CA  . GLY A 1 15  ? -19.983 -7.223  -5.506  0.50 74.55  ? 278  GLY A CA  1 
ATOM   43   C  C   . GLY A 1 15  ? -21.379 -7.664  -5.103  0.50 73.15  ? 278  GLY A C   1 
ATOM   44   O  O   . GLY A 1 15  ? -21.544 -8.129  -3.960  0.50 76.87  ? 278  GLY A O   1 
ATOM   45   N  N   . LYS A 1 16  ? -22.353 -7.526  -6.006  0.50 71.45  ? 279  LYS A N   1 
ATOM   46   C  CA  . LYS A 1 16  ? -23.781 -7.849  -5.745  0.50 73.85  ? 279  LYS A CA  1 
ATOM   47   C  C   . LYS A 1 16  ? -23.868 -9.247  -5.123  0.50 72.62  ? 279  LYS A C   1 
ATOM   48   O  O   . LYS A 1 16  ? -24.504 -9.377  -4.059  0.50 72.63  ? 279  LYS A O   1 
ATOM   49   C  CB  . LYS A 1 16  ? -24.592 -7.741  -7.041  0.50 77.49  ? 279  LYS A CB  1 
ATOM   50   C  CG  . LYS A 1 16  ? -26.103 -7.863  -6.890  0.50 79.98  ? 279  LYS A CG  1 
ATOM   51   C  CD  . LYS A 1 16  ? -26.856 -7.526  -8.164  0.50 83.56  ? 279  LYS A CD  1 
ATOM   52   C  CE  . LYS A 1 16  ? -28.359 -7.657  -8.030  0.50 87.37  ? 279  LYS A CE  1 
ATOM   53   N  NZ  . LYS A 1 16  ? -28.913 -6.698  -7.046  0.50 89.07  ? 279  LYS A NZ  1 
ATOM   54   N  N   . ARG A 1 17  ? -23.241 -10.244 -5.757  0.50 73.02  ? 280  ARG A N   1 
ATOM   55   C  CA  . ARG A 1 17  ? -23.241 -11.660 -5.296  0.50 73.67  ? 280  ARG A CA  1 
ATOM   56   C  C   . ARG A 1 17  ? -22.669 -11.727 -3.877  0.50 74.04  ? 280  ARG A C   1 
ATOM   57   O  O   . ARG A 1 17  ? -23.320 -12.341 -3.003  0.50 67.05  ? 280  ARG A O   1 
ATOM   58   C  CB  . ARG A 1 17  ? -22.426 -12.546 -6.244  0.50 73.25  ? 280  ARG A CB  1 
ATOM   59   C  CG  . ARG A 1 17  ? -23.243 -13.174 -7.364  0.50 70.48  ? 280  ARG A CG  1 
ATOM   60   C  CD  . ARG A 1 17  ? -22.380 -13.874 -8.395  0.50 65.87  ? 280  ARG A CD  1 
ATOM   61   N  NE  . ARG A 1 17  ? -21.673 -12.927 -9.240  0.50 63.93  ? 280  ARG A NE  1 
ATOM   62   C  CZ  . ARG A 1 17  ? -20.836 -13.265 -10.213 0.50 64.36  ? 280  ARG A CZ  1 
ATOM   63   N  NH1 . ARG A 1 17  ? -20.588 -14.540 -10.461 0.50 61.44  ? 280  ARG A NH1 1 
ATOM   64   N  NH2 . ARG A 1 17  ? -20.246 -12.326 -10.931 0.50 64.57  ? 280  ARG A NH2 1 
ATOM   65   N  N   . ILE A 1 18  ? -21.500 -11.108 -3.676  0.50 78.20  ? 281  ILE A N   1 
ATOM   66   C  CA  . ILE A 1 18  ? -20.738 -11.083 -2.392  0.50 80.96  ? 281  ILE A CA  1 
ATOM   67   C  C   . ILE A 1 18  ? -21.613 -10.443 -1.309  0.50 86.48  ? 281  ILE A C   1 
ATOM   68   O  O   . ILE A 1 18  ? -21.793 -11.075 -0.245  0.50 91.84  ? 281  ILE A O   1 
ATOM   69   C  CB  . ILE A 1 18  ? -19.400 -10.335 -2.570  0.50 81.40  ? 281  ILE A CB  1 
ATOM   70   C  CG1 . ILE A 1 18  ? -18.520 -10.995 -3.634  0.50 80.28  ? 281  ILE A CG1 1 
ATOM   71   C  CG2 . ILE A 1 18  ? -18.668 -10.207 -1.244  0.50 82.04  ? 281  ILE A CG2 1 
ATOM   72   C  CD1 . ILE A 1 18  ? -17.196 -10.305 -3.845  0.50 81.30  ? 281  ILE A CD1 1 
ATOM   73   N  N   . GLU A 1 19  ? -22.146 -9.247  -1.584  0.50 89.45  ? 282  GLU A N   1 
ATOM   74   C  CA  . GLU A 1 19  ? -22.954 -8.440  -0.628  0.50 89.60  ? 282  GLU A CA  1 
ATOM   75   C  C   . GLU A 1 19  ? -24.245 -9.190  -0.275  0.50 86.20  ? 282  GLU A C   1 
ATOM   76   O  O   . GLU A 1 19  ? -24.660 -9.110  0.895   0.50 86.86  ? 282  GLU A O   1 
ATOM   77   C  CB  . GLU A 1 19  ? -23.257 -7.058  -1.211  0.50 92.87  ? 282  GLU A CB  1 
ATOM   78   C  CG  . GLU A 1 19  ? -22.030 -6.349  -1.759  0.50 99.05  ? 282  GLU A CG  1 
ATOM   79   C  CD  . GLU A 1 19  ? -20.737 -6.596  -0.994  0.50 103.64 ? 282  GLU A CD  1 
ATOM   80   O  OE1 . GLU A 1 19  ? -20.792 -6.688  0.254   0.50 106.54 ? 282  GLU A OE1 1 
ATOM   81   O  OE2 . GLU A 1 19  ? -19.674 -6.699  -1.648  0.50 103.02 ? 282  GLU A OE2 1 
ATOM   82   N  N   . LYS A 1 20  ? -24.851 -9.887  -1.244  1.00 84.71  ? 283  LYS A N   1 
ATOM   83   C  CA  . LYS A 1 20  ? -26.105 -10.664 -1.015  1.00 78.41  ? 283  LYS A CA  1 
ATOM   84   C  C   . LYS A 1 20  ? -25.844 -11.813 -0.046  1.00 81.57  ? 283  LYS A C   1 
ATOM   85   O  O   . LYS A 1 20  ? -26.746 -12.111 0.773   1.00 80.34  ? 283  LYS A O   1 
ATOM   86   C  CB  . LYS A 1 20  ? -26.666 -11.275 -2.297  1.00 76.93  ? 283  LYS A CB  1 
ATOM   87   C  CG  . LYS A 1 20  ? -27.705 -12.360 -2.044  1.00 75.31  ? 283  LYS A CG  1 
ATOM   88   C  CD  . LYS A 1 20  ? -28.733 -12.489 -3.142  1.00 84.56  ? 283  LYS A CD  1 
ATOM   89   C  CE  . LYS A 1 20  ? -29.963 -13.281 -2.740  1.00 80.79  ? 283  LYS A CE  1 
ATOM   90   N  NZ  . LYS A 1 20  ? -29.737 -14.744 -2.832  1.00 80.87  ? 283  LYS A NZ  1 
ATOM   91   N  N   . ILE A 1 21  ? -24.680 -12.453 -0.176  1.00 75.19  ? 284  ILE A N   1 
ATOM   92   C  CA  . ILE A 1 21  ? -24.268 -13.582 0.702   1.00 85.94  ? 284  ILE A CA  1 
ATOM   93   C  C   . ILE A 1 21  ? -23.974 -13.032 2.111   1.00 90.56  ? 284  ILE A C   1 
ATOM   94   O  O   . ILE A 1 21  ? -24.469 -13.626 3.098   1.00 77.86  ? 284  ILE A O   1 
ATOM   95   C  CB  . ILE A 1 21  ? -23.074 -14.337 0.084   1.00 92.82  ? 284  ILE A CB  1 
ATOM   96   C  CG1 . ILE A 1 21  ? -23.484 -15.041 -1.214  1.00 92.71  ? 284  ILE A CG1 1 
ATOM   97   C  CG2 . ILE A 1 21  ? -22.462 -15.309 1.086   1.00 90.57  ? 284  ILE A CG2 1 
ATOM   98   C  CD1 . ILE A 1 21  ? -22.327 -15.428 -2.127  1.00 83.69  ? 284  ILE A CD1 1 
ATOM   99   N  N   . LYS A 1 22  ? -23.212 -11.937 2.211   1.00 85.40  ? 285  LYS A N   1 
ATOM   100  C  CA  . LYS A 1 22  ? -22.885 -11.269 3.503   1.00 84.47  ? 285  LYS A CA  1 
ATOM   101  C  C   . LYS A 1 22  ? -24.182 -11.017 4.290   1.00 90.46  ? 285  LYS A C   1 
ATOM   102  O  O   . LYS A 1 22  ? -24.185 -11.270 5.501   1.00 93.02  ? 285  LYS A O   1 
ATOM   103  C  CB  . LYS A 1 22  ? -22.094 -9.986  3.239   1.00 84.50  ? 285  LYS A CB  1 
ATOM   104  C  CG  . LYS A 1 22  ? -21.794 -9.135  4.464   1.00 94.52  ? 285  LYS A CG  1 
ATOM   105  C  CD  . LYS A 1 22  ? -20.919 -7.927  4.166   1.00 100.10 ? 285  LYS A CD  1 
ATOM   106  C  CE  . LYS A 1 22  ? -20.888 -6.917  5.298   1.00 100.43 ? 285  LYS A CE  1 
ATOM   107  N  NZ  . LYS A 1 22  ? -20.218 -5.656  4.889   1.00 103.35 ? 285  LYS A NZ  1 
ATOM   108  N  N   . GLN A 1 23  ? -25.253 -10.578 3.617   1.00 102.96 ? 286  GLN A N   1 
ATOM   109  C  CA  . GLN A 1 23  ? -26.556 -10.178 4.229   1.00 104.64 ? 286  GLN A CA  1 
ATOM   110  C  C   . GLN A 1 23  ? -27.353 -11.366 4.800   1.00 101.03 ? 286  GLN A C   1 
ATOM   111  O  O   . GLN A 1 23  ? -28.104 -11.166 5.769   1.00 110.63 ? 286  GLN A O   1 
ATOM   112  C  CB  . GLN A 1 23  ? -27.431 -9.443  3.212   1.00 111.90 ? 286  GLN A CB  1 
ATOM   113  C  CG  . GLN A 1 23  ? -27.028 -7.992  3.002   1.00 115.52 ? 286  GLN A CG  1 
ATOM   114  C  CD  . GLN A 1 23  ? -27.693 -7.392  1.786   1.00 120.53 ? 286  GLN A CD  1 
ATOM   115  O  OE1 . GLN A 1 23  ? -28.692 -7.900  1.278   1.00 120.25 ? 286  GLN A OE1 1 
ATOM   116  N  NE2 . GLN A 1 23  ? -27.130 -6.299  1.299   1.00 122.82 ? 286  GLN A NE2 1 
ATOM   117  N  N   . GLU A 1 24  ? -27.205 -12.558 4.211   0.50 100.24 ? 287  GLU A N   1 
ATOM   118  C  CA  . GLU A 1 24  ? -27.909 -13.798 4.641   0.50 100.29 ? 287  GLU A CA  1 
ATOM   119  C  C   . GLU A 1 24  ? -27.124 -14.467 5.778   0.50 100.08 ? 287  GLU A C   1 
ATOM   120  O  O   . GLU A 1 24  ? -27.641 -15.438 6.360   0.50 96.20  ? 287  GLU A O   1 
ATOM   121  C  CB  . GLU A 1 24  ? -28.089 -14.750 3.458   0.50 101.57 ? 287  GLU A CB  1 
ATOM   122  C  CG  . GLU A 1 24  ? -29.073 -14.245 2.418   0.50 103.78 ? 287  GLU A CG  1 
ATOM   123  C  CD  . GLU A 1 24  ? -29.478 -15.269 1.371   0.50 103.22 ? 287  GLU A CD  1 
ATOM   124  O  OE1 . GLU A 1 24  ? -30.409 -14.978 0.591   0.50 101.69 ? 287  GLU A OE1 1 
ATOM   125  O  OE2 . GLU A 1 24  ? -28.864 -16.356 1.339   0.50 100.73 ? 287  GLU A OE2 1 
ATOM   126  N  N   . HIS A 1 25  ? -25.922 -13.964 6.073   0.50 105.57 ? 288  HIS A N   1 
ATOM   127  C  CA  . HIS A 1 25  ? -25.036 -14.445 7.167   0.50 108.12 ? 288  HIS A CA  1 
ATOM   128  C  C   . HIS A 1 25  ? -24.414 -13.240 7.889   0.50 113.47 ? 288  HIS A C   1 
ATOM   129  O  O   . HIS A 1 25  ? -23.193 -13.276 8.154   0.50 114.44 ? 288  HIS A O   1 
ATOM   130  C  CB  . HIS A 1 25  ? -23.972 -15.401 6.604   0.50 103.22 ? 288  HIS A CB  1 
ATOM   131  C  CG  . HIS A 1 25  ? -24.528 -16.519 5.785   0.50 97.82  ? 288  HIS A CG  1 
ATOM   132  N  ND1 . HIS A 1 25  ? -25.184 -17.597 6.350   0.50 97.21  ? 288  HIS A ND1 1 
ATOM   133  C  CD2 . HIS A 1 25  ? -24.517 -16.741 4.453   0.50 94.82  ? 288  HIS A CD2 1 
ATOM   134  C  CE1 . HIS A 1 25  ? -25.557 -18.432 5.401   0.50 93.24  ? 288  HIS A CE1 1 
ATOM   135  N  NE2 . HIS A 1 25  ? -25.161 -17.929 4.228   0.50 92.05  ? 288  HIS A NE2 1 
ATOM   136  N  N   . GLU A 1 26  ? -25.228 -12.219 8.189   1.00 119.77 ? 289  GLU A N   1 
ATOM   137  C  CA  . GLU A 1 26  ? -24.765 -10.931 8.804   1.00 120.44 ? 289  GLU A CA  1 
ATOM   138  C  C   . GLU A 1 26  ? -24.312 -11.155 10.256  1.00 115.65 ? 289  GLU A C   1 
ATOM   139  O  O   . GLU A 1 26  ? -23.401 -10.442 10.739  1.00 94.11  ? 289  GLU A O   1 
ATOM   140  C  CB  . GLU A 1 26  ? -25.879 -9.875  8.744   1.00 120.79 ? 289  GLU A CB  1 
ATOM   141  C  CG  . GLU A 1 26  ? -25.402 -8.436  8.928   1.00 120.65 ? 289  GLU A CG  1 
ATOM   142  C  CD  . GLU A 1 26  ? -24.624 -7.820  7.767   1.00 122.75 ? 289  GLU A CD  1 
ATOM   143  O  OE1 . GLU A 1 26  ? -23.404 -7.598  7.932   1.00 127.83 ? 289  GLU A OE1 1 
ATOM   144  O  OE2 . GLU A 1 26  ? -25.236 -7.533  6.707   1.00 108.18 ? 289  GLU A OE2 1 
ATOM   145  N  N   . THR A 1 27  ? -24.948 -12.117 10.932  0.50 114.90 ? 290  THR A N   1 
ATOM   146  C  CA  . THR A 1 27  ? -24.648 -12.541 12.325  0.50 117.98 ? 290  THR A CA  1 
ATOM   147  C  C   . THR A 1 27  ? -23.204 -13.059 12.412  0.50 116.73 ? 290  THR A C   1 
ATOM   148  O  O   . THR A 1 27  ? -22.502 -12.674 13.371  0.50 114.95 ? 290  THR A O   1 
ATOM   149  C  CB  . THR A 1 27  ? -25.672 -13.583 12.797  0.50 120.34 ? 290  THR A CB  1 
ATOM   150  O  OG1 . THR A 1 27  ? -25.977 -14.441 11.697  0.50 124.07 ? 290  THR A OG1 1 
ATOM   151  C  CG2 . THR A 1 27  ? -26.954 -12.962 13.307  0.50 119.42 ? 290  THR A CG2 1 
ATOM   152  N  N   . SER A 1 28  ? -22.777 -13.871 11.434  1.00 114.97 ? 291  SER A N   1 
ATOM   153  C  CA  . SER A 1 28  ? -21.455 -14.573 11.428  1.00 96.32  ? 291  SER A CA  1 
ATOM   154  C  C   . SER A 1 28  ? -20.329 -13.820 10.700  1.00 88.63  ? 291  SER A C   1 
ATOM   155  O  O   . SER A 1 28  ? -19.166 -14.151 10.962  1.00 92.22  ? 291  SER A O   1 
ATOM   156  C  CB  . SER A 1 28  ? -21.583 -15.924 10.814  1.00 87.60  ? 291  SER A CB  1 
ATOM   157  O  OG  . SER A 1 28  ? -22.753 -16.584 11.260  1.00 88.18  ? 291  SER A OG  1 
ATOM   158  N  N   . TRP A 1 29  ? -20.623 -12.907 9.776   1.00 82.11  ? 292  TRP A N   1 
ATOM   159  C  CA  . TRP A 1 29  ? -19.601 -12.339 8.853   1.00 91.94  ? 292  TRP A CA  1 
ATOM   160  C  C   . TRP A 1 29  ? -18.337 -11.946 9.626   1.00 98.71  ? 292  TRP A C   1 
ATOM   161  O  O   . TRP A 1 29  ? -18.479 -11.298 10.683  1.00 105.03 ? 292  TRP A O   1 
ATOM   162  C  CB  . TRP A 1 29  ? -20.157 -11.141 8.075   1.00 91.74  ? 292  TRP A CB  1 
ATOM   163  C  CG  . TRP A 1 29  ? -19.359 -10.774 6.862   1.00 80.57  ? 292  TRP A CG  1 
ATOM   164  C  CD1 . TRP A 1 29  ? -18.603 -9.651  6.672   1.00 82.54  ? 292  TRP A CD1 1 
ATOM   165  C  CD2 . TRP A 1 29  ? -19.266 -11.533 5.643   1.00 78.71  ? 292  TRP A CD2 1 
ATOM   166  N  NE1 . TRP A 1 29  ? -18.047 -9.655  5.419   1.00 82.40  ? 292  TRP A NE1 1 
ATOM   167  C  CE2 . TRP A 1 29  ? -18.440 -10.797 4.763   1.00 88.39  ? 292  TRP A CE2 1 
ATOM   168  C  CE3 . TRP A 1 29  ? -19.814 -12.746 5.208   1.00 79.79  ? 292  TRP A CE3 1 
ATOM   169  C  CZ2 . TRP A 1 29  ? -18.139 -11.253 3.478   1.00 89.99  ? 292  TRP A CZ2 1 
ATOM   170  C  CZ3 . TRP A 1 29  ? -19.517 -13.191 3.939   1.00 79.01  ? 292  TRP A CZ3 1 
ATOM   171  C  CH2 . TRP A 1 29  ? -18.690 -12.453 3.089   1.00 84.32  ? 292  TRP A CH2 1 
ATOM   172  N  N   . HIS A 1 30  ? -17.156 -12.302 9.103   1.00 98.72  ? 293  HIS A N   1 
ATOM   173  C  CA  . HIS A 1 30  ? -15.835 -11.889 9.650   1.00 102.84 ? 293  HIS A CA  1 
ATOM   174  C  C   . HIS A 1 30  ? -14.745 -11.939 8.581   1.00 103.70 ? 293  HIS A C   1 
ATOM   175  O  O   . HIS A 1 30  ? -14.628 -12.985 7.933   1.00 114.36 ? 293  HIS A O   1 
ATOM   176  C  CB  . HIS A 1 30  ? -15.441 -12.768 10.838  1.00 99.00  ? 293  HIS A CB  1 
ATOM   177  C  CG  . HIS A 1 30  ? -15.362 -14.233 10.568  1.00 87.51  ? 293  HIS A CG  1 
ATOM   178  N  ND1 . HIS A 1 30  ? -16.468 -15.065 10.671  1.00 89.94  ? 293  HIS A ND1 1 
ATOM   179  C  CD2 . HIS A 1 30  ? -14.308 -15.033 10.304  1.00 86.00  ? 293  HIS A CD2 1 
ATOM   180  C  CE1 . HIS A 1 30  ? -16.102 -16.315 10.454  1.00 85.72  ? 293  HIS A CE1 1 
ATOM   181  N  NE2 . HIS A 1 30  ? -14.776 -16.323 10.231  1.00 87.27  ? 293  HIS A NE2 1 
ATOM   182  N  N   . TYR A 1 31  ? -13.963 -10.864 8.449   1.00 97.97  ? 294  TYR A N   1 
ATOM   183  C  CA  . TYR A 1 31  ? -12.762 -10.787 7.576   1.00 107.14 ? 294  TYR A CA  1 
ATOM   184  C  C   . TYR A 1 31  ? -11.564 -11.428 8.282   1.00 111.30 ? 294  TYR A C   1 
ATOM   185  O  O   . TYR A 1 31  ? -10.772 -10.698 8.908   1.00 131.20 ? 294  TYR A O   1 
ATOM   186  C  CB  . TYR A 1 31  ? -12.425 -9.341  7.203   1.00 110.03 ? 294  TYR A CB  1 
ATOM   187  C  CG  . TYR A 1 31  ? -11.237 -9.217  6.283   1.00 121.66 ? 294  TYR A CG  1 
ATOM   188  C  CD1 . TYR A 1 31  ? -10.136 -8.439  6.617   1.00 127.71 ? 294  TYR A CD1 1 
ATOM   189  C  CD2 . TYR A 1 31  ? -11.202 -9.911  5.082   1.00 128.95 ? 294  TYR A CD2 1 
ATOM   190  C  CE1 . TYR A 1 31  ? -9.045  -8.333  5.766   1.00 124.29 ? 294  TYR A CE1 1 
ATOM   191  C  CE2 . TYR A 1 31  ? -10.120 -9.821  4.223   1.00 125.85 ? 294  TYR A CE2 1 
ATOM   192  C  CZ  . TYR A 1 31  ? -9.041  -9.027  4.566   1.00 117.46 ? 294  TYR A CZ  1 
ATOM   193  O  OH  . TYR A 1 31  ? -7.987  -8.947  3.712   1.00 101.84 ? 294  TYR A OH  1 
ATOM   194  N  N   . ASP A 1 32  ? -11.432 -12.751 8.156   1.00 115.56 ? 295  ASP A N   1 
ATOM   195  C  CA  . ASP A 1 32  ? -10.331 -13.569 8.739   1.00 119.38 ? 295  ASP A CA  1 
ATOM   196  C  C   . ASP A 1 32  ? -8.975  -13.070 8.203   1.00 118.44 ? 295  ASP A C   1 
ATOM   197  O  O   . ASP A 1 32  ? -8.937  -12.435 7.117   1.00 112.96 ? 295  ASP A O   1 
ATOM   198  C  CB  . ASP A 1 32  ? -10.569 -15.055 8.450   1.00 113.71 ? 295  ASP A CB  1 
ATOM   199  C  CG  . ASP A 1 32  ? -9.894  -16.008 9.418   1.00 111.52 ? 295  ASP A CG  1 
ATOM   200  O  OD1 . ASP A 1 32  ? -8.664  -15.895 9.588   1.00 107.96 ? 295  ASP A OD1 1 
ATOM   201  O  OD2 . ASP A 1 32  ? -10.608 -16.856 9.990   1.00 95.96  ? 295  ASP A OD2 1 
ATOM   202  N  N   . GLN A 1 33  ? -7.903  -13.350 8.955   0.50 119.61 ? 296  GLN A N   1 
ATOM   203  C  CA  . GLN A 1 33  ? -6.497  -12.976 8.632   0.50 121.77 ? 296  GLN A CA  1 
ATOM   204  C  C   . GLN A 1 33  ? -5.682  -14.254 8.404   0.50 121.14 ? 296  GLN A C   1 
ATOM   205  O  O   . GLN A 1 33  ? -4.543  -14.151 7.903   0.50 111.92 ? 296  GLN A O   1 
ATOM   206  C  CB  . GLN A 1 33  ? -5.900  -12.133 9.761   0.50 123.07 ? 296  GLN A CB  1 
ATOM   207  C  CG  . GLN A 1 33  ? -6.594  -10.791 9.959   0.50 124.16 ? 296  GLN A CG  1 
ATOM   208  C  CD  . GLN A 1 33  ? -6.389  -9.861  8.787   0.50 126.67 ? 296  GLN A CD  1 
ATOM   209  O  OE1 . GLN A 1 33  ? -5.836  -10.241 7.757   0.50 124.97 ? 296  GLN A OE1 1 
ATOM   210  N  NE2 . GLN A 1 33  ? -6.835  -8.624  8.937   0.50 127.40 ? 296  GLN A NE2 1 
ATOM   211  N  N   . ASP A 1 34  ? -6.255  -15.408 8.766   0.50 124.60 ? 297  ASP A N   1 
ATOM   212  C  CA  . ASP A 1 34  ? -5.670  -16.759 8.548   0.50 126.04 ? 297  ASP A CA  1 
ATOM   213  C  C   . ASP A 1 34  ? -6.374  -17.421 7.356   0.50 127.23 ? 297  ASP A C   1 
ATOM   214  O  O   . ASP A 1 34  ? -6.937  -18.520 7.539   0.50 125.36 ? 297  ASP A O   1 
ATOM   215  C  CB  . ASP A 1 34  ? -5.786  -17.630 9.803   0.50 124.69 ? 297  ASP A CB  1 
ATOM   216  C  CG  . ASP A 1 34  ? -4.958  -17.140 10.980  0.50 125.88 ? 297  ASP A CG  1 
ATOM   217  O  OD1 . ASP A 1 34  ? -4.987  -15.923 11.251  0.50 125.76 ? 297  ASP A OD1 1 
ATOM   218  O  OD2 . ASP A 1 34  ? -4.289  -17.981 11.615  0.50 125.16 ? 297  ASP A OD2 1 
ATOM   219  N  N   . HIS A 1 35  ? -6.345  -16.765 6.189   1.00 127.78 ? 298  HIS A N   1 
ATOM   220  C  CA  . HIS A 1 35  ? -6.940  -17.286 4.925   1.00 113.59 ? 298  HIS A CA  1 
ATOM   221  C  C   . HIS A 1 35  ? -5.815  -17.875 4.075   1.00 107.21 ? 298  HIS A C   1 
ATOM   222  O  O   . HIS A 1 35  ? -4.865  -17.173 3.715   1.00 91.25  ? 298  HIS A O   1 
ATOM   223  C  CB  . HIS A 1 35  ? -7.789  -16.215 4.219   1.00 102.33 ? 298  HIS A CB  1 
ATOM   224  C  CG  . HIS A 1 35  ? -7.045  -15.060 3.626   1.00 97.45  ? 298  HIS A CG  1 
ATOM   225  N  ND1 . HIS A 1 35  ? -7.076  -13.798 4.189   1.00 104.59 ? 298  HIS A ND1 1 
ATOM   226  C  CD2 . HIS A 1 35  ? -6.315  -14.945 2.494   1.00 95.38  ? 298  HIS A CD2 1 
ATOM   227  C  CE1 . HIS A 1 35  ? -6.375  -12.963 3.443   1.00 102.37 ? 298  HIS A CE1 1 
ATOM   228  N  NE2 . HIS A 1 35  ? -5.895  -13.641 2.398   1.00 96.21  ? 298  HIS A NE2 1 
ATOM   229  N  N   . PRO A 1 36  ? -5.868  -19.195 3.772   1.00 91.21  ? 299  PRO A N   1 
ATOM   230  C  CA  . PRO A 1 36  ? -4.819  -19.864 3.003   1.00 88.08  ? 299  PRO A CA  1 
ATOM   231  C  C   . PRO A 1 36  ? -4.802  -19.557 1.498   1.00 99.00  ? 299  PRO A C   1 
ATOM   232  O  O   . PRO A 1 36  ? -4.281  -20.361 0.750   1.00 116.05 ? 299  PRO A O   1 
ATOM   233  C  CB  . PRO A 1 36  ? -5.150  -21.348 3.225   1.00 90.37  ? 299  PRO A CB  1 
ATOM   234  C  CG  . PRO A 1 36  ? -6.646  -21.366 3.391   1.00 92.24  ? 299  PRO A CG  1 
ATOM   235  C  CD  . PRO A 1 36  ? -6.917  -20.125 4.206   1.00 89.44  ? 299  PRO A CD  1 
ATOM   236  N  N   . TYR A 1 37  ? -5.329  -18.406 1.082   1.00 95.22  ? 300  TYR A N   1 
ATOM   237  C  CA  . TYR A 1 37  ? -5.451  -18.028 -0.347  1.00 89.05  ? 300  TYR A CA  1 
ATOM   238  C  C   . TYR A 1 37  ? -4.361  -17.014 -0.682  1.00 94.55  ? 300  TYR A C   1 
ATOM   239  O  O   . TYR A 1 37  ? -4.314  -15.929 -0.042  1.00 89.50  ? 300  TYR A O   1 
ATOM   240  C  CB  . TYR A 1 37  ? -6.869  -17.530 -0.634  1.00 80.88  ? 300  TYR A CB  1 
ATOM   241  C  CG  . TYR A 1 37  ? -7.919  -18.450 -0.073  1.00 68.42  ? 300  TYR A CG  1 
ATOM   242  C  CD1 . TYR A 1 37  ? -8.184  -19.675 -0.650  1.00 68.84  ? 300  TYR A CD1 1 
ATOM   243  C  CD2 . TYR A 1 37  ? -8.609  -18.121 1.076   1.00 67.95  ? 300  TYR A CD2 1 
ATOM   244  C  CE1 . TYR A 1 37  ? -9.132  -20.537 -0.117  1.00 66.07  ? 300  TYR A CE1 1 
ATOM   245  C  CE2 . TYR A 1 37  ? -9.550  -18.972 1.626   1.00 57.12  ? 300  TYR A CE2 1 
ATOM   246  C  CZ  . TYR A 1 37  ? -9.817  -20.185 1.031   1.00 57.63  ? 300  TYR A CZ  1 
ATOM   247  O  OH  . TYR A 1 37  ? -10.744 -21.022 1.590   1.00 65.60  ? 300  TYR A OH  1 
ATOM   248  N  N   . LYS A 1 38  ? -3.498  -17.382 -1.636  1.00 93.03  ? 301  LYS A N   1 
ATOM   249  C  CA  . LYS A 1 38  ? -2.600  -16.430 -2.343  1.00 100.17 ? 301  LYS A CA  1 
ATOM   250  C  C   . LYS A 1 38  ? -3.261  -16.048 -3.676  1.00 98.39  ? 301  LYS A C   1 
ATOM   251  O  O   . LYS A 1 38  ? -3.569  -14.856 -3.859  1.00 100.33 ? 301  LYS A O   1 
ATOM   252  C  CB  . LYS A 1 38  ? -1.200  -17.031 -2.527  1.00 102.52 ? 301  LYS A CB  1 
ATOM   253  C  CG  . LYS A 1 38  ? -0.124  -16.076 -3.042  1.00 102.83 ? 301  LYS A CG  1 
ATOM   254  C  CD  . LYS A 1 38  ? 0.101   -14.849 -2.175  1.00 103.59 ? 301  LYS A CD  1 
ATOM   255  C  CE  . LYS A 1 38  ? 1.343   -14.062 -2.553  1.00 110.75 ? 301  LYS A CE  1 
ATOM   256  N  NZ  . LYS A 1 38  ? 2.415   -14.176 -1.531  1.00 111.75 ? 301  LYS A NZ  1 
ATOM   257  N  N   . THR A 1 39  ? -3.540  -17.031 -4.540  1.00 94.77  ? 302  THR A N   1 
ATOM   258  C  CA  . THR A 1 39  ? -3.949  -16.815 -5.958  1.00 90.58  ? 302  THR A CA  1 
ATOM   259  C  C   . THR A 1 39  ? -5.443  -16.483 -6.044  1.00 88.21  ? 302  THR A C   1 
ATOM   260  O  O   . THR A 1 39  ? -5.792  -15.657 -6.896  1.00 87.76  ? 302  THR A O   1 
ATOM   261  C  CB  . THR A 1 39  ? -3.601  -18.024 -6.831  1.00 79.92  ? 302  THR A CB  1 
ATOM   262  O  OG1 . THR A 1 39  ? -4.469  -19.069 -6.398  1.00 74.98  ? 302  THR A OG1 1 
ATOM   263  C  CG2 . THR A 1 39  ? -2.142  -18.417 -6.719  1.00 81.83  ? 302  THR A CG2 1 
ATOM   264  N  N   . TRP A 1 40  ? -6.283  -17.126 -5.227  1.00 77.86  ? 303  TRP A N   1 
ATOM   265  C  CA  . TRP A 1 40  ? -7.706  -16.750 -5.048  1.00 78.03  ? 303  TRP A CA  1 
ATOM   266  C  C   . TRP A 1 40  ? -7.767  -15.458 -4.225  1.00 83.06  ? 303  TRP A C   1 
ATOM   267  O  O   . TRP A 1 40  ? -7.139  -15.445 -3.155  1.00 96.97  ? 303  TRP A O   1 
ATOM   268  C  CB  . TRP A 1 40  ? -8.491  -17.864 -4.351  1.00 76.45  ? 303  TRP A CB  1 
ATOM   269  C  CG  . TRP A 1 40  ? -8.726  -19.100 -5.164  1.00 75.64  ? 303  TRP A CG  1 
ATOM   270  C  CD1 . TRP A 1 40  ? -7.885  -20.164 -5.279  1.00 80.47  ? 303  TRP A CD1 1 
ATOM   271  C  CD2 . TRP A 1 40  ? -9.898  -19.439 -5.924  1.00 72.81  ? 303  TRP A CD2 1 
ATOM   272  N  NE1 . TRP A 1 40  ? -8.442  -21.127 -6.070  1.00 84.39  ? 303  TRP A NE1 1 
ATOM   273  C  CE2 . TRP A 1 40  ? -9.682  -20.717 -6.477  1.00 80.17  ? 303  TRP A CE2 1 
ATOM   274  C  CE3 . TRP A 1 40  ? -11.100 -18.789 -6.207  1.00 69.56  ? 303  TRP A CE3 1 
ATOM   275  C  CZ2 . TRP A 1 40  ? -10.625 -21.360 -7.279  1.00 76.56  ? 303  TRP A CZ2 1 
ATOM   276  C  CZ3 . TRP A 1 40  ? -12.035 -19.424 -6.993  1.00 70.08  ? 303  TRP A CZ3 1 
ATOM   277  C  CH2 . TRP A 1 40  ? -11.805 -20.693 -7.518  1.00 72.07  ? 303  TRP A CH2 1 
ATOM   278  N  N   . ALA A 1 41  ? -8.644  -14.532 -4.614  1.00 77.75  ? 304  ALA A N   1 
ATOM   279  C  CA  . ALA A 1 41  ? -8.906  -13.341 -3.783  1.00 74.17  ? 304  ALA A CA  1 
ATOM   280  C  C   . ALA A 1 41  ? -9.924  -13.757 -2.720  1.00 73.78  ? 304  ALA A C   1 
ATOM   281  O  O   . ALA A 1 41  ? -10.960 -14.316 -3.099  1.00 68.61  ? 304  ALA A O   1 
ATOM   282  C  CB  . ALA A 1 41  ? -9.450  -12.234 -4.637  1.00 70.88  ? 304  ALA A CB  1 
ATOM   283  N  N   . TYR A 1 42  ? -9.613  -13.531 -1.442  1.00 80.86  ? 305  TYR A N   1 
ATOM   284  C  CA  . TYR A 1 42  ? -10.528 -13.894 -0.329  1.00 79.17  ? 305  TYR A CA  1 
ATOM   285  C  C   . TYR A 1 42  ? -11.372 -12.674 0.011   1.00 82.92  ? 305  TYR A C   1 
ATOM   286  O  O   . TYR A 1 42  ? -10.853 -11.550 -0.059  1.00 89.12  ? 305  TYR A O   1 
ATOM   287  C  CB  . TYR A 1 42  ? -9.736  -14.378 0.884   1.00 81.45  ? 305  TYR A CB  1 
ATOM   288  C  CG  . TYR A 1 42  ? -10.463 -14.375 2.203   1.00 73.56  ? 305  TYR A CG  1 
ATOM   289  C  CD1 . TYR A 1 42  ? -11.182 -15.480 2.622   1.00 67.76  ? 305  TYR A CD1 1 
ATOM   290  C  CD2 . TYR A 1 42  ? -10.397 -13.282 3.049   1.00 72.54  ? 305  TYR A CD2 1 
ATOM   291  C  CE1 . TYR A 1 42  ? -11.839 -15.490 3.840   1.00 74.10  ? 305  TYR A CE1 1 
ATOM   292  C  CE2 . TYR A 1 42  ? -11.050 -13.275 4.269   1.00 73.21  ? 305  TYR A CE2 1 
ATOM   293  C  CZ  . TYR A 1 42  ? -11.772 -14.384 4.667   1.00 76.64  ? 305  TYR A CZ  1 
ATOM   294  O  OH  . TYR A 1 42  ? -12.419 -14.386 5.866   1.00 74.16  ? 305  TYR A OH  1 
ATOM   295  N  N   . HIS A 1 43  ? -12.633 -12.895 0.367   1.00 83.71  ? 306  HIS A N   1 
ATOM   296  C  CA  . HIS A 1 43  ? -13.532 -11.739 0.595   1.00 86.16  ? 306  HIS A CA  1 
ATOM   297  C  C   . HIS A 1 43  ? -14.070 -11.757 2.026   1.00 82.17  ? 306  HIS A C   1 
ATOM   298  O  O   . HIS A 1 43  ? -14.232 -10.670 2.596   1.00 90.04  ? 306  HIS A O   1 
ATOM   299  C  CB  . HIS A 1 43  ? -14.637 -11.744 -0.470  1.00 83.77  ? 306  HIS A CB  1 
ATOM   300  C  CG  . HIS A 1 43  ? -14.148 -11.446 -1.847  1.00 77.60  ? 306  HIS A CG  1 
ATOM   301  N  ND1 . HIS A 1 43  ? -13.915 -10.158 -2.283  1.00 73.16  ? 306  HIS A ND1 1 
ATOM   302  C  CD2 . HIS A 1 43  ? -13.852 -12.255 -2.885  1.00 76.48  ? 306  HIS A CD2 1 
ATOM   303  C  CE1 . HIS A 1 43  ? -13.493 -10.187 -3.529  1.00 72.68  ? 306  HIS A CE1 1 
ATOM   304  N  NE2 . HIS A 1 43  ? -13.445 -11.461 -3.920  1.00 72.79  ? 306  HIS A NE2 1 
ATOM   305  N  N   . GLY A 1 44  ? -14.345 -12.941 2.571   1.00 74.87  ? 307  GLY A N   1 
ATOM   306  C  CA  . GLY A 1 44  ? -14.921 -13.027 3.922   1.00 70.43  ? 307  GLY A CA  1 
ATOM   307  C  C   . GLY A 1 44  ? -15.289 -14.444 4.299   1.00 77.28  ? 307  GLY A C   1 
ATOM   308  O  O   . GLY A 1 44  ? -15.056 -15.343 3.478   1.00 79.86  ? 307  GLY A O   1 
ATOM   309  N  N   . SER A 1 45  ? -15.859 -14.634 5.492   1.00 82.13  ? 308  SER A N   1 
ATOM   310  C  CA  . SER A 1 45  ? -16.175 -15.999 5.979   1.00 82.61  ? 308  SER A CA  1 
ATOM   311  C  C   . SER A 1 45  ? -17.375 -15.973 6.925   1.00 89.23  ? 308  SER A C   1 
ATOM   312  O  O   . SER A 1 45  ? -17.575 -14.943 7.584   1.00 90.88  ? 308  SER A O   1 
ATOM   313  C  CB  . SER A 1 45  ? -14.981 -16.599 6.658   1.00 83.26  ? 308  SER A CB  1 
ATOM   314  O  OG  . SER A 1 45  ? -13.814 -16.449 5.867   1.00 73.33  ? 308  SER A OG  1 
ATOM   315  N  N   . TYR A 1 46  ? -18.127 -17.072 6.988   0.50 88.87  ? 309  TYR A N   1 
ATOM   316  C  CA  . TYR A 1 46  ? -19.316 -17.194 7.874   0.50 89.83  ? 309  TYR A CA  1 
ATOM   317  C  C   . TYR A 1 46  ? -19.449 -18.644 8.360   0.50 92.77  ? 309  TYR A C   1 
ATOM   318  O  O   . TYR A 1 46  ? -18.869 -19.551 7.738   0.50 93.30  ? 309  TYR A O   1 
ATOM   319  C  CB  . TYR A 1 46  ? -20.573 -16.686 7.160   0.50 88.82  ? 309  TYR A CB  1 
ATOM   320  C  CG  . TYR A 1 46  ? -20.993 -17.450 5.927   0.50 86.14  ? 309  TYR A CG  1 
ATOM   321  C  CD1 . TYR A 1 46  ? -21.816 -18.561 6.018   0.50 82.36  ? 309  TYR A CD1 1 
ATOM   322  C  CD2 . TYR A 1 46  ? -20.603 -17.039 4.662   0.50 83.81  ? 309  TYR A CD2 1 
ATOM   323  C  CE1 . TYR A 1 46  ? -22.219 -19.259 4.891   0.50 83.27  ? 309  TYR A CE1 1 
ATOM   324  C  CE2 . TYR A 1 46  ? -20.998 -17.724 3.524   0.50 83.43  ? 309  TYR A CE2 1 
ATOM   325  C  CZ  . TYR A 1 46  ? -21.809 -18.838 3.638   0.50 83.87  ? 309  TYR A CZ  1 
ATOM   326  O  OH  . TYR A 1 46  ? -22.200 -19.515 2.519   0.50 83.17  ? 309  TYR A OH  1 
ATOM   327  N  N   . GLU A 1 47  ? -20.204 -18.838 9.446   0.50 98.83  ? 310  GLU A N   1 
ATOM   328  C  CA  . GLU A 1 47  ? -20.343 -20.117 10.193  0.50 104.69 ? 310  GLU A CA  1 
ATOM   329  C  C   . GLU A 1 47  ? -21.110 -21.132 9.337   0.50 106.44 ? 310  GLU A C   1 
ATOM   330  O  O   . GLU A 1 47  ? -22.087 -20.731 8.676   0.50 110.92 ? 310  GLU A O   1 
ATOM   331  C  CB  . GLU A 1 47  ? -21.060 -19.858 11.521  0.50 107.66 ? 310  GLU A CB  1 
ATOM   332  C  CG  . GLU A 1 47  ? -20.791 -20.903 12.591  0.50 108.29 ? 310  GLU A CG  1 
ATOM   333  C  CD  . GLU A 1 47  ? -21.499 -20.650 13.914  0.50 109.18 ? 310  GLU A CD  1 
ATOM   334  O  OE1 . GLU A 1 47  ? -22.744 -20.538 13.909  0.50 104.20 ? 310  GLU A OE1 1 
ATOM   335  O  OE2 . GLU A 1 47  ? -20.806 -20.558 14.948  0.50 110.81 ? 310  GLU A OE2 1 
ATOM   336  N  N   . THR A 1 48  ? -20.676 -22.396 9.355   0.50 111.72 ? 311  THR A N   1 
ATOM   337  C  CA  . THR A 1 48  ? -21.329 -23.538 8.660   0.50 115.10 ? 311  THR A CA  1 
ATOM   338  C  C   . THR A 1 48  ? -21.077 -24.823 9.457   0.50 119.02 ? 311  THR A C   1 
ATOM   339  O  O   . THR A 1 48  ? -20.099 -24.851 10.231  0.50 119.36 ? 311  THR A O   1 
ATOM   340  C  CB  . THR A 1 48  ? -20.840 -23.667 7.211   0.50 113.79 ? 311  THR A CB  1 
ATOM   341  O  OG1 . THR A 1 48  ? -19.440 -23.387 7.179   0.50 110.48 ? 311  THR A OG1 1 
ATOM   342  C  CG2 . THR A 1 48  ? -21.563 -22.737 6.263   0.50 115.48 ? 311  THR A CG2 1 
ATOM   343  N  N   . LYS A 1 49  ? -21.938 -25.830 9.278   0.50 122.41 ? 312  LYS A N   1 
ATOM   344  C  CA  . LYS A 1 49  ? -21.824 -27.173 9.909   0.50 122.04 ? 312  LYS A CA  1 
ATOM   345  C  C   . LYS A 1 49  ? -22.475 -28.209 8.984   0.50 121.67 ? 312  LYS A C   1 
ATOM   346  O  O   . LYS A 1 49  ? -23.713 -28.357 9.029   0.50 117.04 ? 312  LYS A O   1 
ATOM   347  C  CB  . LYS A 1 49  ? -22.452 -27.169 11.307  0.50 121.20 ? 312  LYS A CB  1 
ATOM   348  C  CG  . LYS A 1 49  ? -21.479 -26.888 12.446  0.50 119.33 ? 312  LYS A CG  1 
ATOM   349  C  CD  . LYS A 1 49  ? -22.151 -26.621 13.773  0.50 115.98 ? 312  LYS A CD  1 
ATOM   350  C  CE  . LYS A 1 49  ? -22.864 -25.287 13.810  0.50 114.16 ? 312  LYS A CE  1 
ATOM   351  N  NZ  . LYS A 1 49  ? -23.451 -25.022 15.144  0.50 113.79 ? 312  LYS A NZ  1 
ATOM   352  N  N   . GLN A 1 50  ? -21.654 -28.889 8.178   0.50 122.12 ? 313  GLN A N   1 
ATOM   353  C  CA  . GLN A 1 50  ? -22.090 -29.843 7.124   0.50 121.71 ? 313  GLN A CA  1 
ATOM   354  C  C   . GLN A 1 50  ? -20.855 -30.527 6.524   0.50 124.08 ? 313  GLN A C   1 
ATOM   355  O  O   . GLN A 1 50  ? -19.727 -30.086 6.832   0.50 121.18 ? 313  GLN A O   1 
ATOM   356  C  CB  . GLN A 1 50  ? -22.896 -29.104 6.054   0.50 120.51 ? 313  GLN A CB  1 
ATOM   357  C  CG  . GLN A 1 50  ? -24.388 -29.044 6.347   0.50 118.50 ? 313  GLN A CG  1 
ATOM   358  C  CD  . GLN A 1 50  ? -25.113 -30.260 5.822   0.50 116.20 ? 313  GLN A CD  1 
ATOM   359  O  OE1 . GLN A 1 50  ? -25.046 -30.579 4.637   0.50 112.42 ? 313  GLN A OE1 1 
ATOM   360  N  NE2 . GLN A 1 50  ? -25.816 -30.948 6.707   0.50 113.35 ? 313  GLN A NE2 1 
ATOM   361  N  N   . THR A 1 51  ? -21.070 -31.558 5.699   0.50 126.13 ? 314  THR A N   1 
ATOM   362  C  CA  . THR A 1 51  ? -20.006 -32.388 5.071   0.50 125.26 ? 314  THR A CA  1 
ATOM   363  C  C   . THR A 1 51  ? -18.793 -31.504 4.762   0.50 126.00 ? 314  THR A C   1 
ATOM   364  O  O   . THR A 1 51  ? -18.074 -31.846 3.803   0.50 127.89 ? 314  THR A O   1 
ATOM   365  C  CB  . THR A 1 51  ? -20.518 -33.092 3.807   0.50 122.18 ? 314  THR A CB  1 
ATOM   366  O  OG1 . THR A 1 51  ? -21.838 -33.572 4.058   0.50 120.58 ? 314  THR A OG1 1 
ATOM   367  C  CG2 . THR A 1 51  ? -19.630 -34.239 3.374   0.50 119.83 ? 314  THR A CG2 1 
ATOM   368  N  N   . ALA A 1 54  ? -20.784 -37.872 1.355   1.00 128.78 ? 317  ALA A N   1 
ATOM   369  C  CA  . ALA A 1 54  ? -21.226 -39.010 0.509   1.00 128.78 ? 317  ALA A CA  1 
ATOM   370  C  C   . ALA A 1 54  ? -20.006 -39.733 -0.088  1.00 128.72 ? 317  ALA A C   1 
ATOM   371  O  O   . ALA A 1 54  ? -19.507 -39.280 -1.140  1.00 124.14 ? 317  ALA A O   1 
ATOM   372  C  CB  . ALA A 1 54  ? -22.167 -38.524 -0.573  1.00 122.76 ? 317  ALA A CB  1 
ATOM   373  N  N   . SER A 1 55  ? -19.544 -40.812 0.563   1.00 123.14 ? 318  SER A N   1 
ATOM   374  C  CA  . SER A 1 55  ? -18.443 -41.702 0.094   1.00 106.55 ? 318  SER A CA  1 
ATOM   375  C  C   . SER A 1 55  ? -19.022 -42.808 -0.809  1.00 94.39  ? 318  SER A C   1 
ATOM   376  O  O   . SER A 1 55  ? -20.260 -42.858 -0.985  1.00 83.46  ? 318  SER A O   1 
ATOM   377  C  CB  . SER A 1 55  ? -17.627 -42.259 1.262   1.00 100.01 ? 318  SER A CB  1 
ATOM   378  O  OG  . SER A 1 55  ? -18.287 -43.331 1.929   1.00 89.42  ? 318  SER A OG  1 
ATOM   379  N  N   . SER A 1 56  ? -18.154 -43.639 -1.389  1.00 79.24  ? 319  SER A N   1 
ATOM   380  C  CA  . SER A 1 56  ? -18.513 -44.719 -2.339  1.00 74.31  ? 319  SER A CA  1 
ATOM   381  C  C   . SER A 1 56  ? -19.079 -45.904 -1.552  1.00 71.05  ? 319  SER A C   1 
ATOM   382  O  O   . SER A 1 56  ? -18.397 -46.367 -0.639  1.00 68.61  ? 319  SER A O   1 
ATOM   383  C  CB  . SER A 1 56  ? -17.317 -45.143 -3.147  1.00 79.69  ? 319  SER A CB  1 
ATOM   384  O  OG  . SER A 1 56  ? -16.455 -45.973 -2.373  1.00 67.87  ? 319  SER A OG  1 
ATOM   385  N  N   . MET A 1 57  ? -20.251 -46.410 -1.946  1.00 62.01  ? 320  MET A N   1 
ATOM   386  C  CA  . MET A 1 57  ? -20.912 -47.607 -1.352  1.00 53.11  ? 320  MET A CA  1 
ATOM   387  C  C   . MET A 1 57  ? -20.654 -48.836 -2.248  1.00 41.81  ? 320  MET A C   1 
ATOM   388  O  O   . MET A 1 57  ? -20.561 -48.690 -3.483  1.00 44.14  ? 320  MET A O   1 
ATOM   389  C  CB  . MET A 1 57  ? -22.408 -47.301 -1.236  1.00 58.99  ? 320  MET A CB  1 
ATOM   390  C  CG  . MET A 1 57  ? -22.702 -45.900 -0.626  1.00 63.40  ? 320  MET A CG  1 
ATOM   391  S  SD  . MET A 1 57  ? -22.117 -45.705 1.120   1.00 69.22  ? 320  MET A SD  1 
ATOM   392  C  CE  . MET A 1 57  ? -23.035 -47.004 1.949   1.00 58.82  ? 320  MET A CE  1 
ATOM   393  N  N   . VAL A 1 58  ? -20.502 -50.023 -1.685  1.00 35.36  ? 321  VAL A N   1 
ATOM   394  C  CA  . VAL A 1 58  ? -20.357 -51.252 -2.517  1.00 35.21  ? 321  VAL A CA  1 
ATOM   395  C  C   . VAL A 1 58  ? -21.731 -51.778 -2.973  1.00 36.56  ? 321  VAL A C   1 
ATOM   396  O  O   . VAL A 1 58  ? -22.640 -51.890 -2.141  1.00 34.55  ? 321  VAL A O   1 
ATOM   397  C  CB  . VAL A 1 58  ? -19.594 -52.362 -1.790  1.00 38.55  ? 321  VAL A CB  1 
ATOM   398  C  CG1 . VAL A 1 58  ? -19.434 -53.605 -2.669  1.00 38.30  ? 321  VAL A CG1 1 
ATOM   399  C  CG2 . VAL A 1 58  ? -18.244 -51.877 -1.313  1.00 42.22  ? 321  VAL A CG2 1 
ATOM   400  N  N   . ASN A 1 59  ? -21.819 -52.148 -4.251  1.00 29.90  ? 322  ASN A N   1 
ATOM   401  C  CA  . ASN A 1 59  ? -22.923 -52.903 -4.863  1.00 29.99  ? 322  ASN A CA  1 
ATOM   402  C  C   . ASN A 1 59  ? -22.787 -54.394 -4.525  1.00 31.90  ? 322  ASN A C   1 
ATOM   403  O  O   . ASN A 1 59  ? -21.989 -55.095 -5.160  1.00 32.51  ? 322  ASN A O   1 
ATOM   404  C  CB  . ASN A 1 59  ? -22.919 -52.621 -6.364  1.00 32.43  ? 322  ASN A CB  1 
ATOM   405  C  CG  . ASN A 1 59  ? -24.069 -53.301 -7.075  1.00 32.92  ? 322  ASN A CG  1 
ATOM   406  O  OD1 . ASN A 1 59  ? -24.472 -54.425 -6.714  1.00 33.94  ? 322  ASN A OD1 1 
ATOM   407  N  ND2 . ASN A 1 59  ? -24.595 -52.615 -8.068  1.00 32.32  ? 322  ASN A ND2 1 
ATOM   408  N  N   . GLY A 1 60  ? -23.635 -54.894 -3.639  1.00 30.95  ? 323  GLY A N   1 
ATOM   409  C  CA  . GLY A 1 60  ? -23.638 -56.286 -3.169  1.00 29.65  ? 323  GLY A CA  1 
ATOM   410  C  C   . GLY A 1 60  ? -24.005 -57.303 -4.260  1.00 33.68  ? 323  GLY A C   1 
ATOM   411  O  O   . GLY A 1 60  ? -23.455 -58.433 -4.281  1.00 35.48  ? 323  GLY A O   1 
ATOM   412  N  N   . VAL A 1 61  ? -24.857 -56.951 -5.207  1.00 31.44  ? 324  VAL A N   1 
ATOM   413  C  CA  . VAL A 1 61  ? -25.171 -57.912 -6.294  1.00 31.48  ? 324  VAL A CA  1 
ATOM   414  C  C   . VAL A 1 61  ? -23.889 -58.207 -7.097  1.00 29.38  ? 324  VAL A C   1 
ATOM   415  O  O   . VAL A 1 61  ? -23.599 -59.384 -7.307  1.00 30.04  ? 324  VAL A O   1 
ATOM   416  C  CB  . VAL A 1 61  ? -26.363 -57.411 -7.128  1.00 30.52  ? 324  VAL A CB  1 
ATOM   417  C  CG1 . VAL A 1 61  ? -26.696 -58.306 -8.286  1.00 30.13  ? 324  VAL A CG1 1 
ATOM   418  C  CG2 . VAL A 1 61  ? -27.572 -57.248 -6.234  1.00 29.76  ? 324  VAL A CG2 1 
ATOM   419  N  N   . VAL A 1 62  ? -23.156 -57.200 -7.570  1.00 32.18  ? 325  VAL A N   1 
ATOM   420  C  CA  . VAL A 1 62  ? -21.912 -57.411 -8.376  1.00 30.86  ? 325  VAL A CA  1 
ATOM   421  C  C   . VAL A 1 62  ? -20.841 -58.087 -7.490  1.00 31.32  ? 325  VAL A C   1 
ATOM   422  O  O   . VAL A 1 62  ? -20.263 -59.093 -7.894  1.00 27.70  ? 325  VAL A O   1 
ATOM   423  C  CB  . VAL A 1 62  ? -21.408 -56.102 -8.994  1.00 30.82  ? 325  VAL A CB  1 
ATOM   424  C  CG1 . VAL A 1 62  ? -20.113 -56.338 -9.720  1.00 31.55  ? 325  VAL A CG1 1 
ATOM   425  C  CG2 . VAL A 1 62  ? -22.430 -55.495 -9.944  1.00 29.71  ? 325  VAL A CG2 1 
ATOM   426  N  N   . ARG A 1 63  ? -20.671 -57.645 -6.251  1.00 28.41  ? 326  ARG A N   1 
ATOM   427  C  CA  . ARG A 1 63  ? -19.638 -58.249 -5.390  1.00 30.29  ? 326  ARG A CA  1 
ATOM   428  C  C   . ARG A 1 63  ? -19.891 -59.759 -5.195  1.00 31.49  ? 326  ARG A C   1 
ATOM   429  O  O   . ARG A 1 63  ? -18.934 -60.552 -5.378  1.00 32.28  ? 326  ARG A O   1 
ATOM   430  C  CB  . ARG A 1 63  ? -19.477 -57.503 -4.073  1.00 29.65  ? 326  ARG A CB  1 
ATOM   431  C  CG  . ARG A 1 63  ? -18.418 -58.166 -3.196  1.00 30.90  ? 326  ARG A CG  1 
ATOM   432  C  CD  . ARG A 1 63  ? -17.676 -57.215 -2.300  1.00 30.37  ? 326  ARG A CD  1 
ATOM   433  N  NE  . ARG A 1 63  ? -18.555 -56.732 -1.258  1.00 31.42  ? 326  ARG A NE  1 
ATOM   434  C  CZ  . ARG A 1 63  ? -18.188 -55.911 -0.288  1.00 35.08  ? 326  ARG A CZ  1 
ATOM   435  N  NH1 . ARG A 1 63  ? -16.916 -55.542 -0.177  1.00 34.18  ? 326  ARG A NH1 1 
ATOM   436  N  NH2 . ARG A 1 63  ? -19.097 -55.453 0.568   1.00 33.88  ? 326  ARG A NH2 1 
ATOM   437  N  N   . LEU A 1 64  ? -21.095 -60.187 -4.822  1.00 32.81  ? 327  LEU A N   1 
ATOM   438  C  CA  . LEU A 1 64  ? -21.381 -61.629 -4.555  1.00 29.30  ? 327  LEU A CA  1 
ATOM   439  C  C   . LEU A 1 64  ? -21.115 -62.445 -5.824  1.00 27.45  ? 327  LEU A C   1 
ATOM   440  O  O   . LEU A 1 64  ? -20.763 -63.626 -5.718  1.00 28.82  ? 327  LEU A O   1 
ATOM   441  C  CB  . LEU A 1 64  ? -22.830 -61.782 -4.090  1.00 29.28  ? 327  LEU A CB  1 
ATOM   442  C  CG  . LEU A 1 64  ? -23.048 -61.432 -2.630  1.00 31.91  ? 327  LEU A CG  1 
ATOM   443  C  CD1 . LEU A 1 64  ? -24.492 -61.630 -2.245  1.00 33.32  ? 327  LEU A CD1 1 
ATOM   444  C  CD2 . LEU A 1 64  ? -22.176 -62.272 -1.710  1.00 33.15  ? 327  LEU A CD2 1 
ATOM   445  N  N   . LEU A 1 65  ? -21.225 -61.841 -7.002  1.00 27.72  ? 328  LEU A N   1 
ATOM   446  C  CA  . LEU A 1 65  ? -21.047 -62.590 -8.277  1.00 27.95  ? 328  LEU A CA  1 
ATOM   447  C  C   . LEU A 1 65  ? -19.634 -62.418 -8.854  1.00 27.68  ? 328  LEU A C   1 
ATOM   448  O  O   . LEU A 1 65  ? -19.417 -62.955 -9.955  1.00 26.56  ? 328  LEU A O   1 
ATOM   449  C  CB  . LEU A 1 65  ? -22.149 -62.138 -9.245  1.00 28.26  ? 328  LEU A CB  1 
ATOM   450  C  CG  . LEU A 1 65  ? -23.536 -62.557 -8.770  1.00 31.65  ? 328  LEU A CG  1 
ATOM   451  C  CD1 . LEU A 1 65  ? -24.649 -61.938 -9.592  1.00 31.13  ? 328  LEU A CD1 1 
ATOM   452  C  CD2 . LEU A 1 65  ? -23.639 -64.065 -8.785  1.00 35.12  ? 328  LEU A CD2 1 
ATOM   453  N  N   . THR A 1 66  ? -18.709 -61.763 -8.128  1.00 26.67  ? 329  THR A N   1 
ATOM   454  C  CA  . THR A 1 66  ? -17.292 -61.613 -8.527  1.00 26.07  ? 329  THR A CA  1 
ATOM   455  C  C   . THR A 1 66  ? -16.376 -61.986 -7.338  1.00 29.66  ? 329  THR A C   1 
ATOM   456  O  O   . THR A 1 66  ? -15.409 -61.271 -7.065  1.00 31.12  ? 329  THR A O   1 
ATOM   457  C  CB  . THR A 1 66  ? -17.049 -60.192 -9.075  1.00 27.46  ? 329  THR A CB  1 
ATOM   458  O  OG1 . THR A 1 66  ? -17.465 -59.218 -8.103  1.00 23.54  ? 329  THR A OG1 1 
ATOM   459  C  CG2 . THR A 1 66  ? -17.765 -60.005 -10.400 1.00 28.70  ? 329  THR A CG2 1 
ATOM   460  N  N   . LYS A 1 67  ? -16.595 -63.126 -6.712  1.00 26.91  ? 330  LYS A N   1 
ATOM   461  C  CA  . LYS A 1 67  ? -15.912 -63.526 -5.472  1.00 28.63  ? 330  LYS A CA  1 
ATOM   462  C  C   . LYS A 1 67  ? -14.397 -63.637 -5.635  1.00 29.07  ? 330  LYS A C   1 
ATOM   463  O  O   . LYS A 1 67  ? -13.701 -63.339 -4.685  1.00 30.18  ? 330  LYS A O   1 
ATOM   464  C  CB  . LYS A 1 67  ? -16.454 -64.857 -4.980  1.00 31.49  ? 330  LYS A CB  1 
ATOM   465  C  CG  . LYS A 1 67  ? -16.107 -65.140 -3.535  1.00 33.07  ? 330  LYS A CG  1 
ATOM   466  C  CD  . LYS A 1 67  ? -16.520 -66.507 -3.091  1.00 34.47  ? 330  LYS A CD  1 
ATOM   467  C  CE  . LYS A 1 67  ? -16.537 -66.547 -1.582  1.00 38.37  ? 330  LYS A CE  1 
ATOM   468  N  NZ  . LYS A 1 67  ? -16.309 -67.926 -1.138  1.00 44.84  ? 330  LYS A NZ  1 
ATOM   469  N  N   . PRO A 1 68  ? -13.826 -64.141 -6.745  1.00 27.27  ? 331  PRO A N   1 
ATOM   470  C  CA  . PRO A 1 68  ? -12.372 -64.208 -6.892  1.00 30.96  ? 331  PRO A CA  1 
ATOM   471  C  C   . PRO A 1 68  ? -11.687 -62.844 -6.676  1.00 32.94  ? 331  PRO A C   1 
ATOM   472  O  O   . PRO A 1 68  ? -10.534 -62.762 -6.203  1.00 26.38  ? 331  PRO A O   1 
ATOM   473  C  CB  . PRO A 1 68  ? -12.170 -64.730 -8.328  1.00 31.27  ? 331  PRO A CB  1 
ATOM   474  C  CG  . PRO A 1 68  ? -13.387 -65.606 -8.510  1.00 32.49  ? 331  PRO A CG  1 
ATOM   475  C  CD  . PRO A 1 68  ? -14.523 -64.848 -7.824  1.00 30.28  ? 331  PRO A CD  1 
ATOM   476  N  N   . TRP A 1 69  ? -12.400 -61.770 -6.974  1.00 26.71  ? 332  TRP A N   1 
ATOM   477  C  CA  . TRP A 1 69  ? -11.800 -60.430 -6.904  1.00 27.99  ? 332  TRP A CA  1 
ATOM   478  C  C   . TRP A 1 69  ? -11.824 -59.892 -5.474  1.00 28.09  ? 332  TRP A C   1 
ATOM   479  O  O   . TRP A 1 69  ? -11.231 -58.837 -5.235  1.00 30.90  ? 332  TRP A O   1 
ATOM   480  C  CB  . TRP A 1 69  ? -12.450 -59.541 -7.965  1.00 30.00  ? 332  TRP A CB  1 
ATOM   481  C  CG  . TRP A 1 69  ? -12.035 -59.968 -9.339  1.00 27.78  ? 332  TRP A CG  1 
ATOM   482  C  CD1 . TRP A 1 69  ? -10.938 -59.539 -10.016 1.00 31.03  ? 332  TRP A CD1 1 
ATOM   483  C  CD2 . TRP A 1 69  ? -12.620 -61.002 -10.155 1.00 29.02  ? 332  TRP A CD2 1 
ATOM   484  N  NE1 . TRP A 1 69  ? -10.833 -60.195 -11.219 1.00 32.03  ? 332  TRP A NE1 1 
ATOM   485  C  CE2 . TRP A 1 69  ? -11.865 -61.070 -11.347 1.00 29.78  ? 332  TRP A CE2 1 
ATOM   486  C  CE3 . TRP A 1 69  ? -13.738 -61.832 -10.030 1.00 29.51  ? 332  TRP A CE3 1 
ATOM   487  C  CZ2 . TRP A 1 69  ? -12.166 -61.945 -12.385 1.00 31.68  ? 332  TRP A CZ2 1 
ATOM   488  C  CZ3 . TRP A 1 69  ? -14.051 -62.681 -11.067 1.00 29.33  ? 332  TRP A CZ3 1 
ATOM   489  C  CH2 . TRP A 1 69  ? -13.251 -62.767 -12.206 1.00 30.34  ? 332  TRP A CH2 1 
ATOM   490  N  N   . ASP A 1 70  ? -12.464 -60.583 -4.544  1.00 27.77  ? 333  ASP A N   1 
ATOM   491  C  CA  . ASP A 1 70  ? -12.529 -60.118 -3.131  1.00 29.10  ? 333  ASP A CA  1 
ATOM   492  C  C   . ASP A 1 70  ? -11.128 -60.106 -2.499  1.00 29.68  ? 333  ASP A C   1 
ATOM   493  O  O   . ASP A 1 70  ? -11.007 -59.566 -1.376  1.00 36.98  ? 333  ASP A O   1 
ATOM   494  C  CB  . ASP A 1 70  ? -13.428 -61.049 -2.302  1.00 31.20  ? 333  ASP A CB  1 
ATOM   495  C  CG  . ASP A 1 70  ? -14.904 -60.916 -2.609  1.00 30.90  ? 333  ASP A CG  1 
ATOM   496  O  OD1 . ASP A 1 70  ? -15.256 -60.030 -3.424  1.00 31.15  ? 333  ASP A OD1 1 
ATOM   497  O  OD2 . ASP A 1 70  ? -15.678 -61.725 -2.062  1.00 30.93  ? 333  ASP A OD2 1 
ATOM   498  N  N   . ILE A 1 71  ? -10.130 -60.766 -3.102  1.00 33.15  ? 334  ILE A N   1 
ATOM   499  C  CA  . ILE A 1 71  ? -8.750  -60.906 -2.541  1.00 30.95  ? 334  ILE A CA  1 
ATOM   500  C  C   . ILE A 1 71  ? -7.732  -60.173 -3.440  1.00 37.54  ? 334  ILE A C   1 
ATOM   501  O  O   . ILE A 1 71  ? -6.523  -60.322 -3.151  1.00 39.72  ? 334  ILE A O   1 
ATOM   502  C  CB  . ILE A 1 71  ? -8.366  -62.383 -2.282  1.00 31.49  ? 334  ILE A CB  1 
ATOM   503  C  CG1 . ILE A 1 71  ? -8.318  -63.232 -3.546  1.00 31.42  ? 334  ILE A CG1 1 
ATOM   504  C  CG2 . ILE A 1 71  ? -9.244  -63.029 -1.233  1.00 31.47  ? 334  ILE A CG2 1 
ATOM   505  C  CD1 . ILE A 1 71  ? -7.728  -64.572 -3.316  1.00 37.30  ? 334  ILE A CD1 1 
ATOM   506  N  N   . ILE A 1 72  ? -8.171  -59.416 -4.471  1.00 33.79  ? 335  ILE A N   1 
ATOM   507  C  CA  . ILE A 1 72  ? -7.309  -58.613 -5.383  1.00 32.34  ? 335  ILE A CA  1 
ATOM   508  C  C   . ILE A 1 72  ? -7.310  -57.163 -4.905  1.00 35.14  ? 335  ILE A C   1 
ATOM   509  O  O   . ILE A 1 72  ? -8.307  -56.443 -5.040  1.00 34.46  ? 335  ILE A O   1 
ATOM   510  C  CB  . ILE A 1 72  ? -7.808  -58.725 -6.840  1.00 37.83  ? 335  ILE A CB  1 
ATOM   511  C  CG1 . ILE A 1 72  ? -7.869  -60.177 -7.316  1.00 39.53  ? 335  ILE A CG1 1 
ATOM   512  C  CG2 . ILE A 1 72  ? -7.006  -57.821 -7.794  1.00 35.17  ? 335  ILE A CG2 1 
ATOM   513  C  CD1 . ILE A 1 72  ? -6.532  -60.790 -7.518  1.00 43.21  ? 335  ILE A CD1 1 
ATOM   514  N  N   . PRO A 1 73  ? -6.215  -56.667 -4.289  1.00 36.17  ? 336  PRO A N   1 
ATOM   515  C  CA  . PRO A 1 73  ? -6.226  -55.313 -3.736  1.00 34.50  ? 336  PRO A CA  1 
ATOM   516  C  C   . PRO A 1 73  ? -6.536  -54.203 -4.753  1.00 37.28  ? 336  PRO A C   1 
ATOM   517  O  O   . PRO A 1 73  ? -7.124  -53.206 -4.387  1.00 33.40  ? 336  PRO A O   1 
ATOM   518  C  CB  . PRO A 1 73  ? -4.799  -55.191 -3.193  1.00 36.93  ? 336  PRO A CB  1 
ATOM   519  C  CG  . PRO A 1 73  ? -4.509  -56.602 -2.769  1.00 38.51  ? 336  PRO A CG  1 
ATOM   520  C  CD  . PRO A 1 73  ? -4.996  -57.415 -3.955  1.00 35.97  ? 336  PRO A CD  1 
ATOM   521  N  N   . MET A 1 74  ? -6.144  -54.370 -6.013  1.00 38.02  ? 337  MET A N   1 
ATOM   522  C  CA  . MET A 1 74  ? -6.431  -53.344 -7.036  1.00 41.91  ? 337  MET A CA  1 
ATOM   523  C  C   . MET A 1 74  ? -7.950  -53.171 -7.133  1.00 41.24  ? 337  MET A C   1 
ATOM   524  O  O   . MET A 1 74  ? -8.400  -52.015 -7.245  1.00 40.56  ? 337  MET A O   1 
ATOM   525  C  CB  . MET A 1 74  ? -5.806  -53.729 -8.378  1.00 48.34  ? 337  MET A CB  1 
ATOM   526  C  CG  . MET A 1 74  ? -4.267  -53.654 -8.342  1.00 55.27  ? 337  MET A CG  1 
ATOM   527  S  SD  . MET A 1 74  ? -3.605  -51.966 -7.977  1.00 67.97  ? 337  MET A SD  1 
ATOM   528  C  CE  . MET A 1 74  ? -4.533  -50.960 -9.145  1.00 58.94  ? 337  MET A CE  1 
ATOM   529  N  N   . VAL A 1 75  ? -8.715  -54.264 -7.002  1.00 35.55  ? 338  VAL A N   1 
ATOM   530  C  CA  . VAL A 1 75  ? -10.203 -54.189 -7.033  1.00 31.19  ? 338  VAL A CA  1 
ATOM   531  C  C   . VAL A 1 75  ? -10.698 -53.590 -5.719  1.00 28.98  ? 338  VAL A C   1 
ATOM   532  O  O   . VAL A 1 75  ? -11.461 -52.623 -5.758  1.00 31.13  ? 338  VAL A O   1 
ATOM   533  C  CB  . VAL A 1 75  ? -10.838 -55.548 -7.372  1.00 31.36  ? 338  VAL A CB  1 
ATOM   534  C  CG1 . VAL A 1 75  ? -12.343 -55.598 -7.072  1.00 31.54  ? 338  VAL A CG1 1 
ATOM   535  C  CG2 . VAL A 1 75  ? -10.594 -55.910 -8.828  1.00 30.00  ? 338  VAL A CG2 1 
ATOM   536  N  N   . THR A 1 76  ? -10.275 -54.130 -4.585  1.00 34.46  ? 339  THR A N   1 
ATOM   537  C  CA  . THR A 1 76  ? -10.910 -53.876 -3.268  1.00 36.00  ? 339  THR A CA  1 
ATOM   538  C  C   . THR A 1 76  ? -10.570 -52.483 -2.760  1.00 35.49  ? 339  THR A C   1 
ATOM   539  O  O   . THR A 1 76  ? -11.441 -51.888 -2.093  1.00 37.00  ? 339  THR A O   1 
ATOM   540  C  CB  . THR A 1 76  ? -10.535 -54.947 -2.244  1.00 39.24  ? 339  THR A CB  1 
ATOM   541  O  OG1 . THR A 1 76  ? -9.146  -54.988 -1.944  1.00 36.69  ? 339  THR A OG1 1 
ATOM   542  C  CG2 . THR A 1 76  ? -10.949 -56.305 -2.743  1.00 45.01  ? 339  THR A CG2 1 
ATOM   543  N  N   . GLN A 1 77  ? -9.390  -51.968 -3.078  1.00 35.71  ? 340  GLN A N   1 
ATOM   544  C  CA  . GLN A 1 77  ? -8.976  -50.611 -2.620  1.00 40.75  ? 340  GLN A CA  1 
ATOM   545  C  C   . GLN A 1 77  ? -9.764  -49.560 -3.394  1.00 34.32  ? 340  GLN A C   1 
ATOM   546  O  O   . GLN A 1 77  ? -9.893  -48.470 -2.869  1.00 36.26  ? 340  GLN A O   1 
ATOM   547  C  CB  . GLN A 1 77  ? -7.484  -50.316 -2.752  1.00 40.80  ? 340  GLN A CB  1 
ATOM   548  C  CG  . GLN A 1 77  ? -6.587  -51.467 -2.340  1.00 54.11  ? 340  GLN A CG  1 
ATOM   549  C  CD  . GLN A 1 77  ? -5.953  -51.364 -0.976  1.00 63.88  ? 340  GLN A CD  1 
ATOM   550  O  OE1 . GLN A 1 77  ? -6.430  -50.632 -0.106  1.00 68.49  ? 340  GLN A OE1 1 
ATOM   551  N  NE2 . GLN A 1 77  ? -4.880  -52.135 -0.784  1.00 63.67  ? 340  GLN A NE2 1 
ATOM   552  N  N   . MET A 1 78  ? -10.294 -49.860 -4.577  1.00 31.91  ? 341  MET A N   1 
ATOM   553  C  CA  . MET A 1 78  ? -11.041 -48.821 -5.318  1.00 33.82  ? 341  MET A CA  1 
ATOM   554  C  C   . MET A 1 78  ? -12.223 -48.355 -4.480  1.00 37.87  ? 341  MET A C   1 
ATOM   555  O  O   . MET A 1 78  ? -12.644 -47.214 -4.676  1.00 40.23  ? 341  MET A O   1 
ATOM   556  C  CB  . MET A 1 78  ? -11.543 -49.262 -6.689  1.00 36.21  ? 341  MET A CB  1 
ATOM   557  C  CG  . MET A 1 78  ? -10.422 -49.498 -7.698  1.00 42.90  ? 341  MET A CG  1 
ATOM   558  S  SD  . MET A 1 78  ? -11.077 -49.686 -9.392  1.00 50.33  ? 341  MET A SD  1 
ATOM   559  C  CE  . MET A 1 78  ? -12.256 -48.340 -9.356  1.00 43.49  ? 341  MET A CE  1 
ATOM   560  N  N   . ALA A 1 79  ? -12.736 -49.179 -3.566  1.00 40.76  ? 342  ALA A N   1 
ATOM   561  C  CA  . ALA A 1 79  ? -13.987 -48.860 -2.840  1.00 41.77  ? 342  ALA A CA  1 
ATOM   562  C  C   . ALA A 1 79  ? -13.699 -48.086 -1.550  1.00 41.52  ? 342  ALA A C   1 
ATOM   563  O  O   . ALA A 1 79  ? -14.654 -47.647 -0.922  1.00 42.34  ? 342  ALA A O   1 
ATOM   564  C  CB  . ALA A 1 79  ? -14.747 -50.136 -2.562  1.00 42.14  ? 342  ALA A CB  1 
ATOM   565  N  N   . MET A 1 80  ? -12.447 -47.920 -1.139  1.00 45.31  ? 343  MET A N   1 
ATOM   566  C  CA  . MET A 1 80  ? -12.159 -47.227 0.152   1.00 56.31  ? 343  MET A CA  1 
ATOM   567  C  C   . MET A 1 80  ? -12.059 -45.713 -0.105  1.00 60.32  ? 343  MET A C   1 
ATOM   568  O  O   . MET A 1 80  ? -12.069 -45.341 -1.272  1.00 64.86  ? 343  MET A O   1 
ATOM   569  C  CB  . MET A 1 80  ? -10.882 -47.794 0.780   1.00 48.31  ? 343  MET A CB  1 
ATOM   570  C  CG  . MET A 1 80  ? -10.887 -49.326 0.856   1.00 54.42  ? 343  MET A CG  1 
ATOM   571  S  SD  . MET A 1 80  ? -12.243 -50.116 1.873   1.00 55.38  ? 343  MET A SD  1 
ATOM   572  C  CE  . MET A 1 80  ? -11.755 -49.545 3.508   1.00 53.55  ? 343  MET A CE  1 
ATOM   573  N  N   . THR A 1 81  ? -12.046 -44.869 0.937   1.00 80.45  ? 344  THR A N   1 
ATOM   574  C  CA  . THR A 1 81  ? -11.815 -43.405 0.836   1.00 75.47  ? 344  THR A CA  1 
ATOM   575  C  C   . THR A 1 81  ? -12.630 -42.620 1.848   1.00 73.86  ? 344  THR A C   1 
ATOM   576  O  O   . THR A 1 81  ? -13.856 -42.913 1.930   1.00 80.88  ? 344  THR A O   1 
ATOM   577  N  N   . LYS A 1 93  ? -6.621  -28.950 -4.328  0.50 106.86 ? 356  LYS A N   1 
ATOM   578  C  CA  . LYS A 1 93  ? -5.679  -29.032 -3.178  0.50 108.71 ? 356  LYS A CA  1 
ATOM   579  C  C   . LYS A 1 93  ? -4.492  -28.092 -3.425  0.50 114.29 ? 356  LYS A C   1 
ATOM   580  O  O   . LYS A 1 93  ? -4.612  -26.888 -3.113  0.50 116.18 ? 356  LYS A O   1 
ATOM   581  C  CB  . LYS A 1 93  ? -5.200  -30.475 -2.984  0.50 103.34 ? 356  LYS A CB  1 
ATOM   582  C  CG  . LYS A 1 93  ? -4.284  -30.699 -1.788  0.50 100.09 ? 356  LYS A CG  1 
ATOM   583  C  CD  . LYS A 1 93  ? -3.572  -32.036 -1.806  0.50 95.32  ? 356  LYS A CD  1 
ATOM   584  C  CE  . LYS A 1 93  ? -2.763  -32.296 -0.553  0.50 94.16  ? 356  LYS A CE  1 
ATOM   585  N  NZ  . LYS A 1 93  ? -1.618  -31.364 -0.424  0.50 93.72  ? 356  LYS A NZ  1 
ATOM   586  N  N   . GLU A 1 94  ? -3.398  -28.634 -3.973  0.50 115.37 ? 357  GLU A N   1 
ATOM   587  C  CA  . GLU A 1 94  ? -2.137  -27.904 -4.284  0.50 115.14 ? 357  GLU A CA  1 
ATOM   588  C  C   . GLU A 1 94  ? -2.122  -27.477 -5.758  0.50 118.05 ? 357  GLU A C   1 
ATOM   589  O  O   . GLU A 1 94  ? -1.020  -27.183 -6.267  0.50 117.22 ? 357  GLU A O   1 
ATOM   590  C  CB  . GLU A 1 94  ? -0.933  -28.802 -3.993  0.50 111.95 ? 357  GLU A CB  1 
ATOM   591  C  CG  . GLU A 1 94  ? -1.070  -30.204 -4.568  0.50 108.09 ? 357  GLU A CG  1 
ATOM   592  C  CD  . GLU A 1 94  ? 0.117   -31.121 -4.324  0.50 105.38 ? 357  GLU A CD  1 
ATOM   593  O  OE1 . GLU A 1 94  ? -0.094  -32.243 -3.822  0.50 99.11  ? 357  GLU A OE1 1 
ATOM   594  O  OE2 . GLU A 1 94  ? 1.250   -30.714 -4.643  0.50 106.29 ? 357  GLU A OE2 1 
ATOM   595  N  N   . LYS A 1 95  ? -3.293  -27.427 -6.406  1.00 122.56 ? 358  LYS A N   1 
ATOM   596  C  CA  . LYS A 1 95  ? -3.415  -27.305 -7.886  1.00 115.24 ? 358  LYS A CA  1 
ATOM   597  C  C   . LYS A 1 95  ? -4.428  -26.201 -8.204  1.00 107.45 ? 358  LYS A C   1 
ATOM   598  O  O   . LYS A 1 95  ? -4.150  -25.389 -9.114  1.00 96.01  ? 358  LYS A O   1 
ATOM   599  C  CB  . LYS A 1 95  ? -3.891  -28.636 -8.478  1.00 113.70 ? 358  LYS A CB  1 
ATOM   600  C  CG  . LYS A 1 95  ? -3.644  -28.808 -9.968  1.00 105.10 ? 358  LYS A CG  1 
ATOM   601  C  CD  . LYS A 1 95  ? -2.181  -28.877 -10.299 1.00 106.40 ? 358  LYS A CD  1 
ATOM   602  C  CE  . LYS A 1 95  ? -1.934  -29.317 -11.722 1.00 106.77 ? 358  LYS A CE  1 
ATOM   603  N  NZ  . LYS A 1 95  ? -0.638  -30.018 -11.850 1.00 99.31  ? 358  LYS A NZ  1 
ATOM   604  N  N   . VAL A 1 96  ? -5.559  -26.183 -7.486  1.00 104.77 ? 359  VAL A N   1 
ATOM   605  C  CA  . VAL A 1 96  ? -6.603  -25.121 -7.600  1.00 103.81 ? 359  VAL A CA  1 
ATOM   606  C  C   . VAL A 1 96  ? -6.030  -23.777 -7.112  1.00 101.52 ? 359  VAL A C   1 
ATOM   607  O  O   . VAL A 1 96  ? -6.435  -22.754 -7.692  1.00 101.83 ? 359  VAL A O   1 
ATOM   608  C  CB  . VAL A 1 96  ? -7.901  -25.500 -6.863  1.00 98.59  ? 359  VAL A CB  1 
ATOM   609  C  CG1 . VAL A 1 96  ? -7.730  -25.498 -5.350  1.00 104.24 ? 359  VAL A CG1 1 
ATOM   610  C  CG2 . VAL A 1 96  ? -9.049  -24.593 -7.277  1.00 94.67  ? 359  VAL A CG2 1 
ATOM   611  N  N   . ASP A 1 97  ? -5.101  -23.760 -6.139  1.00 102.72 ? 360  ASP A N   1 
ATOM   612  C  CA  . ASP A 1 97  ? -4.520  -22.499 -5.582  1.00 101.53 ? 360  ASP A CA  1 
ATOM   613  C  C   . ASP A 1 97  ? -3.125  -22.224 -6.178  1.00 101.16 ? 360  ASP A C   1 
ATOM   614  O  O   . ASP A 1 97  ? -2.184  -21.900 -5.416  1.00 108.77 ? 360  ASP A O   1 
ATOM   615  C  CB  . ASP A 1 97  ? -4.523  -22.479 -4.043  1.00 100.65 ? 360  ASP A CB  1 
ATOM   616  C  CG  . ASP A 1 97  ? -4.593  -21.086 -3.410  1.00 98.56  ? 360  ASP A CG  1 
ATOM   617  O  OD1 . ASP A 1 97  ? -4.167  -20.098 -4.059  1.00 84.18  ? 360  ASP A OD1 1 
ATOM   618  O  OD2 . ASP A 1 97  ? -5.080  -20.991 -2.260  1.00 95.05  ? 360  ASP A OD2 1 
ATOM   619  N  N   . THR A 1 98  ? -3.005  -22.336 -7.506  0.50 98.15  ? 361  THR A N   1 
ATOM   620  C  CA  . THR A 1 98  ? -1.827  -21.911 -8.310  0.50 95.39  ? 361  THR A CA  1 
ATOM   621  C  C   . THR A 1 98  ? -2.313  -20.896 -9.350  0.50 93.20  ? 361  THR A C   1 
ATOM   622  O  O   . THR A 1 98  ? -3.540  -20.749 -9.477  0.50 89.29  ? 361  THR A O   1 
ATOM   623  C  CB  . THR A 1 98  ? -1.125  -23.115 -8.953  0.50 95.06  ? 361  THR A CB  1 
ATOM   624  O  OG1 . THR A 1 98  ? -1.900  -23.551 -10.071 0.50 93.36  ? 361  THR A OG1 1 
ATOM   625  C  CG2 . THR A 1 98  ? -0.925  -24.263 -7.987  0.50 93.78  ? 361  THR A CG2 1 
ATOM   626  N  N   . ARG A 1 99  ? -1.395  -20.214 -10.042 0.50 98.47  ? 362  ARG A N   1 
ATOM   627  C  CA  . ARG A 1 99  ? -1.721  -19.251 -11.131 0.50 102.48 ? 362  ARG A CA  1 
ATOM   628  C  C   . ARG A 1 99  ? -0.851  -19.556 -12.355 0.50 101.69 ? 362  ARG A C   1 
ATOM   629  O  O   . ARG A 1 99  ? 0.346   -19.851 -12.165 0.50 105.03 ? 362  ARG A O   1 
ATOM   630  C  CB  . ARG A 1 99  ? -1.504  -17.804 -10.676 0.50 106.13 ? 362  ARG A CB  1 
ATOM   631  C  CG  . ARG A 1 99  ? -2.424  -16.801 -11.361 0.50 110.59 ? 362  ARG A CG  1 
ATOM   632  C  CD  . ARG A 1 99  ? -1.874  -15.386 -11.391 0.50 113.90 ? 362  ARG A CD  1 
ATOM   633  N  NE  . ARG A 1 99  ? -0.785  -15.236 -12.348 0.50 118.83 ? 362  ARG A NE  1 
ATOM   634  C  CZ  . ARG A 1 99  ? -0.191  -14.084 -12.642 0.50 118.97 ? 362  ARG A CZ  1 
ATOM   635  N  NH1 . ARG A 1 99  ? -0.584  -12.965 -12.056 0.50 118.96 ? 362  ARG A NH1 1 
ATOM   636  N  NH2 . ARG A 1 99  ? 0.794   -14.055 -13.522 0.50 115.81 ? 362  ARG A NH2 1 
ATOM   637  N  N   . THR A 1 100 ? -1.437  -19.490 -13.555 1.00 98.52  ? 363  THR A N   1 
ATOM   638  C  CA  . THR A 1 100 ? -0.702  -19.616 -14.841 1.00 98.87  ? 363  THR A CA  1 
ATOM   639  C  C   . THR A 1 100 ? -0.261  -18.205 -15.243 1.00 90.65  ? 363  THR A C   1 
ATOM   640  O  O   . THR A 1 100 ? -1.062  -17.274 -15.048 1.00 85.40  ? 363  THR A O   1 
ATOM   641  C  CB  . THR A 1 100 ? -1.544  -20.320 -15.914 1.00 103.91 ? 363  THR A CB  1 
ATOM   642  O  OG1 . THR A 1 100 ? -1.969  -21.575 -15.379 1.00 108.15 ? 363  THR A OG1 1 
ATOM   643  C  CG2 . THR A 1 100 ? -0.794  -20.545 -17.212 1.00 96.23  ? 363  THR A CG2 1 
ATOM   644  N  N   . GLN A 1 101 ? 0.982   -18.060 -15.716 1.00 95.60  ? 364  GLN A N   1 
ATOM   645  C  CA  . GLN A 1 101 ? 1.522   -16.816 -16.335 1.00 97.29  ? 364  GLN A CA  1 
ATOM   646  C  C   . GLN A 1 101 ? 0.612   -16.452 -17.524 1.00 92.17  ? 364  GLN A C   1 
ATOM   647  O  O   . GLN A 1 101 ? -0.167  -17.323 -17.977 1.00 82.01  ? 364  GLN A O   1 
ATOM   648  C  CB  . GLN A 1 101 ? 3.002   -17.015 -16.709 1.00 99.24  ? 364  GLN A CB  1 
ATOM   649  C  CG  . GLN A 1 101 ? 3.700   -15.754 -17.227 1.00 111.04 ? 364  GLN A CG  1 
ATOM   650  C  CD  . GLN A 1 101 ? 5.182   -15.898 -17.505 1.00 114.15 ? 364  GLN A CD  1 
ATOM   651  O  OE1 . GLN A 1 101 ? 5.754   -16.984 -17.445 1.00 110.52 ? 364  GLN A OE1 1 
ATOM   652  N  NE2 . GLN A 1 101 ? 5.828   -14.785 -17.825 1.00 113.33 ? 364  GLN A NE2 1 
ATOM   653  N  N   . GLU A 1 102 ? 0.652   -15.201 -17.985 1.00 84.56  ? 365  GLU A N   1 
ATOM   654  C  CA  . GLU A 1 102 ? -0.053  -14.795 -19.226 1.00 80.47  ? 365  GLU A CA  1 
ATOM   655  C  C   . GLU A 1 102 ? 0.872   -15.119 -20.397 1.00 68.76  ? 365  GLU A C   1 
ATOM   656  O  O   . GLU A 1 102 ? 2.036   -14.735 -20.417 1.00 67.47  ? 365  GLU A O   1 
ATOM   657  C  CB  . GLU A 1 102 ? -0.489  -13.323 -19.172 1.00 91.75  ? 365  GLU A CB  1 
ATOM   658  C  CG  . GLU A 1 102 ? -1.034  -12.802 -20.503 1.00 104.26 ? 365  GLU A CG  1 
ATOM   659  C  CD  . GLU A 1 102 ? -1.989  -11.617 -20.464 1.00 106.24 ? 365  GLU A CD  1 
ATOM   660  O  OE1 . GLU A 1 102 ? -1.675  -10.611 -19.787 1.00 110.29 ? 365  GLU A OE1 1 
ATOM   661  O  OE2 . GLU A 1 102 ? -3.044  -11.696 -21.138 1.00 102.40 ? 365  GLU A OE2 1 
ATOM   662  N  N   . PRO A 1 103 ? 0.387   -15.830 -21.431 1.00 58.68  ? 366  PRO A N   1 
ATOM   663  C  CA  . PRO A 1 103 ? 1.191   -16.112 -22.615 1.00 56.87  ? 366  PRO A CA  1 
ATOM   664  C  C   . PRO A 1 103 ? 1.929   -14.887 -23.165 1.00 53.03  ? 366  PRO A C   1 
ATOM   665  O  O   . PRO A 1 103 ? 1.463   -13.806 -22.966 1.00 53.17  ? 366  PRO A O   1 
ATOM   666  C  CB  . PRO A 1 103 ? 0.141   -16.541 -23.652 1.00 54.29  ? 366  PRO A CB  1 
ATOM   667  C  CG  . PRO A 1 103 ? -0.932  -17.166 -22.821 1.00 56.44  ? 366  PRO A CG  1 
ATOM   668  C  CD  . PRO A 1 103 ? -0.973  -16.366 -21.538 1.00 57.93  ? 366  PRO A CD  1 
ATOM   669  N  N   . LYS A 1 104 ? 3.033   -15.119 -23.871 1.00 60.48  ? 367  LYS A N   1 
ATOM   670  C  CA  . LYS A 1 104 ? 3.718   -14.106 -24.717 1.00 62.72  ? 367  LYS A CA  1 
ATOM   671  C  C   . LYS A 1 104 ? 2.757   -13.650 -25.833 1.00 61.15  ? 367  LYS A C   1 
ATOM   672  O  O   . LYS A 1 104 ? 1.741   -14.322 -26.086 1.00 57.07  ? 367  LYS A O   1 
ATOM   673  C  CB  . LYS A 1 104 ? 5.022   -14.656 -25.324 1.00 67.46  ? 367  LYS A CB  1 
ATOM   674  C  CG  . LYS A 1 104 ? 6.018   -15.338 -24.384 1.00 64.42  ? 367  LYS A CG  1 
ATOM   675  C  CD  . LYS A 1 104 ? 6.251   -14.603 -23.103 1.00 75.67  ? 367  LYS A CD  1 
ATOM   676  C  CE  . LYS A 1 104 ? 7.298   -15.243 -22.215 1.00 79.27  ? 367  LYS A CE  1 
ATOM   677  N  NZ  . LYS A 1 104 ? 7.144   -14.785 -20.811 1.00 76.95  ? 367  LYS A NZ  1 
ATOM   678  N  N   . GLU A 1 105 ? 3.118   -12.565 -26.513 1.00 59.85  ? 368  GLU A N   1 
ATOM   679  C  CA  . GLU A 1 105 ? 2.286   -11.832 -27.495 1.00 62.26  ? 368  GLU A CA  1 
ATOM   680  C  C   . GLU A 1 105 ? 2.084   -12.682 -28.743 1.00 56.86  ? 368  GLU A C   1 
ATOM   681  O  O   . GLU A 1 105 ? 0.992   -12.595 -29.345 1.00 58.36  ? 368  GLU A O   1 
ATOM   682  C  CB  . GLU A 1 105 ? 2.962   -10.509 -27.879 1.00 73.40  ? 368  GLU A CB  1 
ATOM   683  C  CG  . GLU A 1 105 ? 2.884   -9.441  -26.793 1.00 83.34  ? 368  GLU A CG  1 
ATOM   684  C  CD  . GLU A 1 105 ? 1.514   -9.240  -26.158 1.00 93.61  ? 368  GLU A CD  1 
ATOM   685  O  OE1 . GLU A 1 105 ? 0.508   -9.208  -26.903 1.00 105.14 ? 368  GLU A OE1 1 
ATOM   686  O  OE2 . GLU A 1 105 ? 1.450   -9.127  -24.915 1.00 93.78  ? 368  GLU A OE2 1 
ATOM   687  N  N   . GLY A 1 106 ? 3.124   -13.399 -29.162 1.00 54.82  ? 369  GLY A N   1 
ATOM   688  C  CA  . GLY A 1 106 ? 3.073   -14.271 -30.352 1.00 55.18  ? 369  GLY A CA  1 
ATOM   689  C  C   . GLY A 1 106 ? 2.125   -15.435 -30.104 1.00 54.90  ? 369  GLY A C   1 
ATOM   690  O  O   . GLY A 1 106 ? 1.389   -15.806 -31.028 1.00 58.19  ? 369  GLY A O   1 
ATOM   691  N  N   . THR A 1 107 ? 2.162   -15.986 -28.890 1.00 52.12  ? 370  THR A N   1 
ATOM   692  C  CA  . THR A 1 107 ? 1.236   -17.031 -28.392 1.00 56.52  ? 370  THR A CA  1 
ATOM   693  C  C   . THR A 1 107 ? -0.205  -16.514 -28.476 1.00 54.51  ? 370  THR A C   1 
ATOM   694  O  O   . THR A 1 107 ? -0.983  -17.135 -29.213 1.00 55.94  ? 370  THR A O   1 
ATOM   695  C  CB  . THR A 1 107 ? 1.651   -17.480 -26.990 1.00 60.29  ? 370  THR A CB  1 
ATOM   696  O  OG1 . THR A 1 107 ? 3.053   -17.733 -27.055 1.00 59.75  ? 370  THR A OG1 1 
ATOM   697  C  CG2 . THR A 1 107 ? 0.943   -18.736 -26.533 1.00 62.97  ? 370  THR A CG2 1 
ATOM   698  N  N   . LYS A 1 108 ? -0.521  -15.393 -27.813 1.00 54.25  ? 371  LYS A N   1 
ATOM   699  C  CA  . LYS A 1 108 ? -1.846  -14.702 -27.895 1.00 50.04  ? 371  LYS A CA  1 
ATOM   700  C  C   . LYS A 1 108 ? -2.302  -14.551 -29.351 1.00 49.25  ? 371  LYS A C   1 
ATOM   701  O  O   . LYS A 1 108 ? -3.486  -14.818 -29.612 1.00 45.92  ? 371  LYS A O   1 
ATOM   702  C  CB  . LYS A 1 108 ? -1.852  -13.365 -27.145 1.00 49.55  ? 371  LYS A CB  1 
ATOM   703  C  CG  . LYS A 1 108 ? -1.635  -13.506 -25.640 1.00 55.12  ? 371  LYS A CG  1 
ATOM   704  C  CD  . LYS A 1 108 ? -2.033  -12.317 -24.819 1.00 61.42  ? 371  LYS A CD  1 
ATOM   705  C  CE  . LYS A 1 108 ? -1.009  -11.205 -24.796 1.00 75.02  ? 371  LYS A CE  1 
ATOM   706  N  NZ  . LYS A 1 108 ? -1.044  -10.458 -23.510 1.00 87.34  ? 371  LYS A NZ  1 
ATOM   707  N  N   . LYS A 1 109 ? -1.422  -14.183 -30.274 1.00 46.48  ? 372  LYS A N   1 
ATOM   708  C  CA  . LYS A 1 109 ? -1.818  -13.941 -31.687 1.00 52.40  ? 372  LYS A CA  1 
ATOM   709  C  C   . LYS A 1 109 ? -2.241  -15.247 -32.374 1.00 54.02  ? 372  LYS A C   1 
ATOM   710  O  O   . LYS A 1 109 ? -3.218  -15.220 -33.190 1.00 48.39  ? 372  LYS A O   1 
ATOM   711  C  CB  . LYS A 1 109 ? -0.679  -13.280 -32.468 1.00 61.93  ? 372  LYS A CB  1 
ATOM   712  C  CG  . LYS A 1 109 ? -1.093  -12.667 -33.806 1.00 77.49  ? 372  LYS A CG  1 
ATOM   713  C  CD  . LYS A 1 109 ? -2.147  -11.568 -33.691 1.00 80.75  ? 372  LYS A CD  1 
ATOM   714  C  CE  . LYS A 1 109 ? -1.726  -10.471 -32.736 1.00 87.30  ? 372  LYS A CE  1 
ATOM   715  N  NZ  . LYS A 1 109 ? -2.472  -9.221  -33.002 1.00 93.38  ? 372  LYS A NZ  1 
ATOM   716  N  N   . LEU A 1 110 ? -1.490  -16.322 -32.101 1.00 51.81  ? 373  LEU A N   1 
ATOM   717  C  CA  . LEU A 1 110 ? -1.664  -17.668 -32.700 1.00 51.41  ? 373  LEU A CA  1 
ATOM   718  C  C   . LEU A 1 110 ? -3.030  -18.185 -32.248 1.00 44.95  ? 373  LEU A C   1 
ATOM   719  O  O   . LEU A 1 110 ? -3.786  -18.644 -33.113 1.00 44.73  ? 373  LEU A O   1 
ATOM   720  C  CB  . LEU A 1 110 ? -0.519  -18.599 -32.257 1.00 53.19  ? 373  LEU A CB  1 
ATOM   721  C  CG  . LEU A 1 110 ? 0.823   -18.407 -32.979 1.00 54.75  ? 373  LEU A CG  1 
ATOM   722  C  CD1 . LEU A 1 110 ? 1.984   -18.933 -32.150 1.00 47.06  ? 373  LEU A CD1 1 
ATOM   723  C  CD2 . LEU A 1 110 ? 0.794   -19.070 -34.351 1.00 55.40  ? 373  LEU A CD2 1 
ATOM   724  N  N   . MET A 1 111 ? -3.281  -18.059 -30.945 1.00 39.16  ? 374  MET A N   1 
ATOM   725  C  CA  . MET A 1 111 ? -4.478  -18.499 -30.212 1.00 42.56  ? 374  MET A CA  1 
ATOM   726  C  C   . MET A 1 111 ? -5.711  -17.735 -30.715 1.00 50.19  ? 374  MET A C   1 
ATOM   727  O  O   . MET A 1 111 ? -6.735  -18.407 -30.934 1.00 50.21  ? 374  MET A O   1 
ATOM   728  C  CB  . MET A 1 111 ? -4.311  -18.313 -28.694 1.00 40.79  ? 374  MET A CB  1 
ATOM   729  C  CG  . MET A 1 111 ? -3.328  -19.308 -28.077 1.00 43.88  ? 374  MET A CG  1 
ATOM   730  S  SD  . MET A 1 111 ? -3.439  -19.581 -26.275 1.00 51.38  ? 374  MET A SD  1 
ATOM   731  C  CE  . MET A 1 111 ? -3.339  -17.924 -25.609 1.00 49.48  ? 374  MET A CE  1 
ATOM   732  N  N   . LYS A 1 112 ? -5.635  -16.414 -30.917 1.00 48.38  ? 375  LYS A N   1 
ATOM   733  C  CA  . LYS A 1 112 ? -6.791  -15.607 -31.402 1.00 49.19  ? 375  LYS A CA  1 
ATOM   734  C  C   . LYS A 1 112 ? -7.084  -16.015 -32.843 1.00 44.74  ? 375  LYS A C   1 
ATOM   735  O  O   . LYS A 1 112 ? -8.233  -16.125 -33.180 1.00 41.07  ? 375  LYS A O   1 
ATOM   736  C  CB  . LYS A 1 112 ? -6.539  -14.095 -31.377 1.00 58.48  ? 375  LYS A CB  1 
ATOM   737  C  CG  . LYS A 1 112 ? -7.623  -13.243 -30.725 1.00 68.34  ? 375  LYS A CG  1 
ATOM   738  C  CD  . LYS A 1 112 ? -7.407  -13.103 -29.216 1.00 79.15  ? 375  LYS A CD  1 
ATOM   739  C  CE  . LYS A 1 112 ? -8.610  -12.619 -28.429 1.00 81.02  ? 375  LYS A CE  1 
ATOM   740  N  NZ  . LYS A 1 112 ? -8.496  -12.986 -26.993 1.00 78.78  ? 375  LYS A NZ  1 
ATOM   741  N  N   . ILE A 1 113 ? -6.067  -16.225 -33.667 1.00 41.70  ? 376  ILE A N   1 
ATOM   742  C  CA  . ILE A 1 113 ? -6.284  -16.463 -35.122 1.00 43.61  ? 376  ILE A CA  1 
ATOM   743  C  C   . ILE A 1 113 ? -6.886  -17.857 -35.313 1.00 47.36  ? 376  ILE A C   1 
ATOM   744  O  O   . ILE A 1 113 ? -7.817  -18.001 -36.156 1.00 45.35  ? 376  ILE A O   1 
ATOM   745  C  CB  . ILE A 1 113 ? -4.967  -16.340 -35.912 1.00 43.57  ? 376  ILE A CB  1 
ATOM   746  C  CG1 . ILE A 1 113 ? -4.510  -14.890 -36.063 1.00 50.93  ? 376  ILE A CG1 1 
ATOM   747  C  CG2 . ILE A 1 113 ? -5.092  -17.013 -37.272 1.00 43.70  ? 376  ILE A CG2 1 
ATOM   748  C  CD1 . ILE A 1 113 ? -3.062  -14.765 -36.496 1.00 53.11  ? 376  ILE A CD1 1 
ATOM   749  N  N   . THR A 1 114 ? -6.302  -18.853 -34.633 1.00 42.83  ? 377  THR A N   1 
ATOM   750  C  CA  . THR A 1 114 ? -6.753  -20.274 -34.651 1.00 43.11  ? 377  THR A CA  1 
ATOM   751  C  C   . THR A 1 114 ? -8.171  -20.383 -34.079 1.00 38.21  ? 377  THR A C   1 
ATOM   752  O  O   . THR A 1 114 ? -8.964  -21.109 -34.681 1.00 36.74  ? 377  THR A O   1 
ATOM   753  C  CB  . THR A 1 114 ? -5.795  -21.189 -33.879 1.00 39.44  ? 377  THR A CB  1 
ATOM   754  O  OG1 . THR A 1 114 ? -4.482  -20.874 -34.320 1.00 40.99  ? 377  THR A OG1 1 
ATOM   755  C  CG2 . THR A 1 114 ? -6.039  -22.651 -34.122 1.00 37.48  ? 377  THR A CG2 1 
ATOM   756  N  N   . ALA A 1 115 ? -8.472  -19.701 -32.968 1.00 41.05  ? 378  ALA A N   1 
ATOM   757  C  CA  . ALA A 1 115 ? -9.805  -19.733 -32.312 1.00 41.04  ? 378  ALA A CA  1 
ATOM   758  C  C   . ALA A 1 115 ? -10.849 -19.134 -33.264 1.00 44.29  ? 378  ALA A C   1 
ATOM   759  O  O   . ALA A 1 115 ? -11.896 -19.816 -33.535 1.00 42.85  ? 378  ALA A O   1 
ATOM   760  C  CB  . ALA A 1 115 ? -9.799  -19.008 -30.994 1.00 39.20  ? 378  ALA A CB  1 
ATOM   761  N  N   . GLU A 1 116 ? -10.559 -17.943 -33.801 1.00 44.12  ? 379  GLU A N   1 
ATOM   762  C  CA  . GLU A 1 116 ? -11.418 -17.271 -34.812 1.00 50.57  ? 379  GLU A CA  1 
ATOM   763  C  C   . GLU A 1 116 ? -11.757 -18.280 -35.914 1.00 46.53  ? 379  GLU A C   1 
ATOM   764  O  O   . GLU A 1 116 ? -12.946 -18.472 -36.185 1.00 44.47  ? 379  GLU A O   1 
ATOM   765  C  CB  . GLU A 1 116 ? -10.764 -16.003 -35.358 1.00 54.76  ? 379  GLU A CB  1 
ATOM   766  C  CG  . GLU A 1 116 ? -11.516 -15.380 -36.531 1.00 68.47  ? 379  GLU A CG  1 
ATOM   767  C  CD  . GLU A 1 116 ? -11.146 -13.941 -36.884 1.00 76.53  ? 379  GLU A CD  1 
ATOM   768  O  OE1 . GLU A 1 116 ? -10.359 -13.330 -36.126 1.00 75.94  ? 379  GLU A OE1 1 
ATOM   769  O  OE2 . GLU A 1 116 ? -11.660 -13.429 -37.910 1.00 76.72  ? 379  GLU A OE2 1 
ATOM   770  N  N   . TRP A 1 117 ? -10.748 -18.916 -36.497 1.00 42.05  ? 380  TRP A N   1 
ATOM   771  C  CA  . TRP A 1 117 ? -10.904 -19.861 -37.627 1.00 38.44  ? 380  TRP A CA  1 
ATOM   772  C  C   . TRP A 1 117 ? -11.671 -21.114 -37.168 1.00 43.39  ? 380  TRP A C   1 
ATOM   773  O  O   . TRP A 1 117 ? -12.450 -21.684 -37.975 1.00 41.50  ? 380  TRP A O   1 
ATOM   774  C  CB  . TRP A 1 117 ? -9.528  -20.214 -38.172 1.00 38.56  ? 380  TRP A CB  1 
ATOM   775  C  CG  . TRP A 1 117 ? -9.574  -21.267 -39.217 1.00 34.55  ? 380  TRP A CG  1 
ATOM   776  C  CD1 . TRP A 1 117 ? -9.733  -21.070 -40.544 1.00 37.75  ? 380  TRP A CD1 1 
ATOM   777  C  CD2 . TRP A 1 117 ? -9.503  -22.682 -39.026 1.00 36.33  ? 380  TRP A CD2 1 
ATOM   778  N  NE1 . TRP A 1 117 ? -9.705  -22.258 -41.208 1.00 43.48  ? 380  TRP A NE1 1 
ATOM   779  C  CE2 . TRP A 1 117 ? -9.585  -23.271 -40.295 1.00 40.41  ? 380  TRP A CE2 1 
ATOM   780  C  CE3 . TRP A 1 117 ? -9.351  -23.510 -37.917 1.00 39.54  ? 380  TRP A CE3 1 
ATOM   781  C  CZ2 . TRP A 1 117 ? -9.574  -24.650 -40.478 1.00 39.26  ? 380  TRP A CZ2 1 
ATOM   782  C  CZ3 . TRP A 1 117 ? -9.293  -24.869 -38.098 1.00 34.85  ? 380  TRP A CZ3 1 
ATOM   783  C  CH2 . TRP A 1 117 ? -9.422  -25.431 -39.357 1.00 37.68  ? 380  TRP A CH2 1 
ATOM   784  N  N   . LEU A 1 118 ? -11.453 -21.573 -35.934 1.00 41.05  ? 381  LEU A N   1 
ATOM   785  C  CA  . LEU A 1 118 ? -12.032 -22.868 -35.487 1.00 41.00  ? 381  LEU A CA  1 
ATOM   786  C  C   . LEU A 1 118 ? -13.537 -22.678 -35.250 1.00 34.98  ? 381  LEU A C   1 
ATOM   787  O  O   . LEU A 1 118 ? -14.294 -23.469 -35.792 1.00 33.95  ? 381  LEU A O   1 
ATOM   788  C  CB  . LEU A 1 118 ? -11.299 -23.409 -34.252 1.00 41.38  ? 381  LEU A CB  1 
ATOM   789  C  CG  . LEU A 1 118 ? -11.693 -24.839 -33.871 1.00 43.80  ? 381  LEU A CG  1 
ATOM   790  C  CD1 . LEU A 1 118 ? -11.404 -25.801 -35.014 1.00 43.52  ? 381  LEU A CD1 1 
ATOM   791  C  CD2 . LEU A 1 118 ? -10.993 -25.280 -32.587 1.00 42.33  ? 381  LEU A CD2 1 
ATOM   792  N  N   . TRP A 1 119 ? -13.951 -21.629 -34.534 1.00 35.03  ? 382  TRP A N   1 
ATOM   793  C  CA  . TRP A 1 119 ? -15.390 -21.257 -34.382 1.00 37.70  ? 382  TRP A CA  1 
ATOM   794  C  C   . TRP A 1 119 ? -16.080 -21.063 -35.742 1.00 40.67  ? 382  TRP A C   1 
ATOM   795  O  O   . TRP A 1 119 ? -17.230 -21.552 -35.874 1.00 45.54  ? 382  TRP A O   1 
ATOM   796  C  CB  . TRP A 1 119 ? -15.543 -20.019 -33.531 1.00 35.16  ? 382  TRP A CB  1 
ATOM   797  C  CG  . TRP A 1 119 ? -15.378 -20.255 -32.072 1.00 31.88  ? 382  TRP A CG  1 
ATOM   798  C  CD1 . TRP A 1 119 ? -14.644 -19.507 -31.206 1.00 34.82  ? 382  TRP A CD1 1 
ATOM   799  C  CD2 . TRP A 1 119 ? -16.065 -21.237 -31.282 1.00 33.89  ? 382  TRP A CD2 1 
ATOM   800  N  NE1 . TRP A 1 119 ? -14.820 -19.962 -29.926 1.00 37.12  ? 382  TRP A NE1 1 
ATOM   801  C  CE2 . TRP A 1 119 ? -15.686 -21.022 -29.946 1.00 34.05  ? 382  TRP A CE2 1 
ATOM   802  C  CE3 . TRP A 1 119 ? -16.977 -22.253 -31.567 1.00 33.49  ? 382  TRP A CE3 1 
ATOM   803  C  CZ2 . TRP A 1 119 ? -16.138 -21.828 -28.913 1.00 35.42  ? 382  TRP A CZ2 1 
ATOM   804  C  CZ3 . TRP A 1 119 ? -17.457 -23.025 -30.535 1.00 34.02  ? 382  TRP A CZ3 1 
ATOM   805  C  CH2 . TRP A 1 119 ? -17.025 -22.826 -29.233 1.00 32.71  ? 382  TRP A CH2 1 
ATOM   806  N  N   . LYS A 1 120 ? -15.417 -20.475 -36.747 1.00 40.19  ? 383  LYS A N   1 
ATOM   807  C  CA  . LYS A 1 120 ? -15.992 -20.385 -38.124 1.00 43.82  ? 383  LYS A CA  1 
ATOM   808  C  C   . LYS A 1 120 ? -16.184 -21.784 -38.696 1.00 44.19  ? 383  LYS A C   1 
ATOM   809  O  O   . LYS A 1 120 ? -17.266 -22.025 -39.206 1.00 49.86  ? 383  LYS A O   1 
ATOM   810  C  CB  . LYS A 1 120 ? -15.151 -19.581 -39.122 1.00 53.38  ? 383  LYS A CB  1 
ATOM   811  C  CG  . LYS A 1 120 ? -15.299 -18.066 -39.046 1.00 62.52  ? 383  LYS A CG  1 
ATOM   812  C  CD  . LYS A 1 120 ? -15.019 -17.370 -40.370 1.00 69.22  ? 383  LYS A CD  1 
ATOM   813  C  CE  . LYS A 1 120 ? -14.722 -15.890 -40.230 1.00 79.30  ? 383  LYS A CE  1 
ATOM   814  N  NZ  . LYS A 1 120 ? -13.632 -15.626 -39.255 1.00 81.95  ? 383  LYS A NZ  1 
ATOM   815  N  N   . GLU A 1 121 ? -15.189 -22.681 -38.618 1.00 45.46  ? 384  GLU A N   1 
ATOM   816  C  CA  . GLU A 1 121 ? -15.325 -24.066 -39.160 1.00 42.21  ? 384  GLU A CA  1 
ATOM   817  C  C   . GLU A 1 121 ? -16.454 -24.815 -38.455 1.00 37.44  ? 384  GLU A C   1 
ATOM   818  O  O   . GLU A 1 121 ? -17.233 -25.512 -39.151 1.00 41.41  ? 384  GLU A O   1 
ATOM   819  C  CB  . GLU A 1 121 ? -14.084 -24.919 -38.936 1.00 44.00  ? 384  GLU A CB  1 
ATOM   820  C  CG  . GLU A 1 121 ? -12.981 -24.610 -39.900 1.00 51.25  ? 384  GLU A CG  1 
ATOM   821  C  CD  . GLU A 1 121 ? -13.345 -24.722 -41.362 1.00 49.06  ? 384  GLU A CD  1 
ATOM   822  O  OE1 . GLU A 1 121 ? -13.719 -25.828 -41.820 1.00 51.05  ? 384  GLU A OE1 1 
ATOM   823  O  OE2 . GLU A 1 121 ? -13.223 -23.701 -42.020 1.00 49.34  ? 384  GLU A OE2 1 
ATOM   824  N  N   . LEU A 1 122 ? -16.509 -24.741 -37.125 1.00 35.99  ? 385  LEU A N   1 
ATOM   825  C  CA  . LEU A 1 122 ? -17.530 -25.488 -36.330 1.00 37.57  ? 385  LEU A CA  1 
ATOM   826  C  C   . LEU A 1 122 ? -18.934 -24.952 -36.666 1.00 35.57  ? 385  LEU A C   1 
ATOM   827  O  O   . LEU A 1 122 ? -19.894 -25.759 -36.668 1.00 39.86  ? 385  LEU A O   1 
ATOM   828  C  CB  . LEU A 1 122 ? -17.217 -25.356 -34.836 1.00 35.07  ? 385  LEU A CB  1 
ATOM   829  C  CG  . LEU A 1 122 ? -15.928 -26.058 -34.395 1.00 36.86  ? 385  LEU A CG  1 
ATOM   830  C  CD1 . LEU A 1 122 ? -15.654 -25.887 -32.912 1.00 31.75  ? 385  LEU A CD1 1 
ATOM   831  C  CD2 . LEU A 1 122 ? -15.991 -27.530 -34.752 1.00 37.01  ? 385  LEU A CD2 1 
ATOM   832  N  N   . GLY A 1 123 ? -19.026 -23.665 -36.997 1.00 35.98  ? 386  GLY A N   1 
ATOM   833  C  CA  . GLY A 1 123 ? -20.286 -22.976 -37.342 1.00 41.92  ? 386  GLY A CA  1 
ATOM   834  C  C   . GLY A 1 123 ? -20.759 -23.186 -38.778 1.00 42.71  ? 386  GLY A C   1 
ATOM   835  O  O   . GLY A 1 123 ? -21.904 -22.872 -39.025 1.00 42.95  ? 386  GLY A O   1 
ATOM   836  N  N   . LYS A 1 124 ? -19.958 -23.705 -39.711 1.00 42.95  ? 387  LYS A N   1 
ATOM   837  C  CA  . LYS A 1 124 ? -20.358 -23.681 -41.148 1.00 47.26  ? 387  LYS A CA  1 
ATOM   838  C  C   . LYS A 1 124 ? -21.684 -24.413 -41.366 1.00 50.51  ? 387  LYS A C   1 
ATOM   839  O  O   . LYS A 1 124 ? -22.424 -23.984 -42.228 1.00 55.79  ? 387  LYS A O   1 
ATOM   840  C  CB  . LYS A 1 124 ? -19.297 -24.262 -42.078 1.00 45.32  ? 387  LYS A CB  1 
ATOM   841  C  CG  . LYS A 1 124 ? -18.183 -23.277 -42.433 1.00 52.62  ? 387  LYS A CG  1 
ATOM   842  C  CD  . LYS A 1 124 ? -17.133 -23.866 -43.385 1.00 58.15  ? 387  LYS A CD  1 
ATOM   843  C  CE  . LYS A 1 124 ? -15.893 -23.008 -43.572 1.00 59.57  ? 387  LYS A CE  1 
ATOM   844  N  NZ  . LYS A 1 124 ? -14.891 -23.711 -44.421 1.00 64.88  ? 387  LYS A NZ  1 
ATOM   845  N  N   . LYS A 1 125 ? -21.956 -25.484 -40.633 1.00 49.33  ? 388  LYS A N   1 
ATOM   846  C  CA  . LYS A 1 125 ? -23.136 -26.345 -40.848 1.00 45.26  ? 388  LYS A CA  1 
ATOM   847  C  C   . LYS A 1 125 ? -23.983 -26.463 -39.570 1.00 40.49  ? 388  LYS A C   1 
ATOM   848  O  O   . LYS A 1 125 ? -24.671 -27.435 -39.447 1.00 44.56  ? 388  LYS A O   1 
ATOM   849  C  CB  . LYS A 1 125 ? -22.671 -27.728 -41.272 1.00 46.22  ? 388  LYS A CB  1 
ATOM   850  C  CG  . LYS A 1 125 ? -22.021 -27.811 -42.643 1.00 59.54  ? 388  LYS A CG  1 
ATOM   851  C  CD  . LYS A 1 125 ? -21.596 -29.247 -42.990 1.00 66.64  ? 388  LYS A CD  1 
ATOM   852  C  CE  . LYS A 1 125 ? -20.388 -29.725 -42.193 1.00 75.11  ? 388  LYS A CE  1 
ATOM   853  N  NZ  . LYS A 1 125 ? -20.513 -31.137 -41.741 1.00 78.43  ? 388  LYS A NZ  1 
ATOM   854  N  N   . LYS A 1 126 ? -23.904 -25.520 -38.645 1.00 39.91  ? 389  LYS A N   1 
ATOM   855  C  CA  . LYS A 1 126 ? -24.639 -25.553 -37.351 1.00 45.12  ? 389  LYS A CA  1 
ATOM   856  C  C   . LYS A 1 126 ? -25.120 -24.133 -37.051 1.00 48.04  ? 389  LYS A C   1 
ATOM   857  O  O   . LYS A 1 126 ? -24.353 -23.183 -37.335 1.00 49.26  ? 389  LYS A O   1 
ATOM   858  C  CB  . LYS A 1 126 ? -23.781 -25.894 -36.121 1.00 43.70  ? 389  LYS A CB  1 
ATOM   859  C  CG  . LYS A 1 126 ? -23.150 -27.268 -36.077 1.00 43.65  ? 389  LYS A CG  1 
ATOM   860  C  CD  . LYS A 1 126 ? -24.141 -28.377 -35.858 1.00 44.53  ? 389  LYS A CD  1 
ATOM   861  C  CE  . LYS A 1 126 ? -23.474 -29.725 -35.941 1.00 43.67  ? 389  LYS A CE  1 
ATOM   862  N  NZ  . LYS A 1 126 ? -24.440 -30.820 -35.935 1.00 43.08  ? 389  LYS A NZ  1 
ATOM   863  N  N   . THR A 1 127 ? -26.273 -24.016 -36.379 1.00 46.57  ? 390  THR A N   1 
ATOM   864  C  CA  . THR A 1 127 ? -26.907 -22.725 -36.011 1.00 48.22  ? 390  THR A CA  1 
ATOM   865  C  C   . THR A 1 127 ? -26.922 -22.606 -34.492 1.00 39.45  ? 390  THR A C   1 
ATOM   866  O  O   . THR A 1 127 ? -27.695 -23.294 -33.831 1.00 43.05  ? 390  THR A O   1 
ATOM   867  C  CB  . THR A 1 127 ? -28.327 -22.662 -36.610 1.00 59.28  ? 390  THR A CB  1 
ATOM   868  O  OG1 . THR A 1 127 ? -28.243 -22.848 -38.027 1.00 57.57  ? 390  THR A OG1 1 
ATOM   869  C  CG2 . THR A 1 127 ? -29.054 -21.373 -36.289 1.00 56.44  ? 390  THR A CG2 1 
ATOM   870  N  N   . PRO A 1 128 ? -26.127 -21.708 -33.873 1.00 39.97  ? 391  PRO A N   1 
ATOM   871  C  CA  . PRO A 1 128 ? -26.247 -21.489 -32.428 1.00 38.84  ? 391  PRO A CA  1 
ATOM   872  C  C   . PRO A 1 128 ? -27.720 -21.165 -32.085 1.00 46.28  ? 391  PRO A C   1 
ATOM   873  O  O   . PRO A 1 128 ? -28.421 -20.576 -32.905 1.00 47.76  ? 391  PRO A O   1 
ATOM   874  C  CB  . PRO A 1 128 ? -25.285 -20.337 -32.092 1.00 37.55  ? 391  PRO A CB  1 
ATOM   875  C  CG  . PRO A 1 128 ? -24.591 -19.966 -33.406 1.00 38.55  ? 391  PRO A CG  1 
ATOM   876  C  CD  . PRO A 1 128 ? -25.125 -20.847 -34.519 1.00 37.30  ? 391  PRO A CD  1 
ATOM   877  N  N   . ARG A 1 129 ? -28.201 -21.606 -30.924 1.00 45.54  ? 392  ARG A N   1 
ATOM   878  C  CA  . ARG A 1 129 ? -29.625 -21.441 -30.546 1.00 45.19  ? 392  ARG A CA  1 
ATOM   879  C  C   . ARG A 1 129 ? -29.809 -21.715 -29.057 1.00 50.96  ? 392  ARG A C   1 
ATOM   880  O  O   . ARG A 1 129 ? -28.986 -22.461 -28.508 1.00 46.87  ? 392  ARG A O   1 
ATOM   881  C  CB  . ARG A 1 129 ? -30.522 -22.302 -31.444 1.00 45.10  ? 392  ARG A CB  1 
ATOM   882  C  CG  . ARG A 1 129 ? -30.231 -23.788 -31.448 1.00 42.48  ? 392  ARG A CG  1 
ATOM   883  C  CD  . ARG A 1 129 ? -31.127 -24.437 -30.471 1.00 42.53  ? 392  ARG A CD  1 
ATOM   884  N  NE  . ARG A 1 129 ? -30.906 -25.860 -30.319 1.00 44.47  ? 392  ARG A NE  1 
ATOM   885  C  CZ  . ARG A 1 129 ? -31.440 -26.553 -29.328 1.00 44.27  ? 392  ARG A CZ  1 
ATOM   886  N  NH1 . ARG A 1 129 ? -32.270 -25.956 -28.486 1.00 44.95  ? 392  ARG A NH1 1 
ATOM   887  N  NH2 . ARG A 1 129 ? -31.200 -27.839 -29.221 1.00 40.96  ? 392  ARG A NH2 1 
ATOM   888  N  N   . MET A 1 130 ? -30.802 -21.061 -28.426 1.00 51.79  ? 393  MET A N   1 
ATOM   889  C  CA  . MET A 1 130 ? -31.089 -21.218 -26.981 1.00 47.61  ? 393  MET A CA  1 
ATOM   890  C  C   . MET A 1 130 ? -31.698 -22.590 -26.767 1.00 50.23  ? 393  MET A C   1 
ATOM   891  O  O   . MET A 1 130 ? -32.535 -23.047 -27.589 1.00 48.98  ? 393  MET A O   1 
ATOM   892  C  CB  . MET A 1 130 ? -32.058 -20.175 -26.423 1.00 58.13  ? 393  MET A CB  1 
ATOM   893  C  CG  . MET A 1 130 ? -31.509 -18.769 -26.466 1.00 68.18  ? 393  MET A CG  1 
ATOM   894  S  SD  . MET A 1 130 ? -32.566 -17.497 -25.688 1.00 75.92  ? 393  MET A SD  1 
ATOM   895  C  CE  . MET A 1 130 ? -34.187 -17.943 -26.318 1.00 78.66  ? 393  MET A CE  1 
ATOM   896  N  N   . CYS A 1 131 ? -31.282 -23.246 -25.697 1.00 50.34  ? 394  CYS A N   1 
ATOM   897  C  CA  . CYS A 1 131 ? -31.991 -24.444 -25.209 1.00 50.90  ? 394  CYS A CA  1 
ATOM   898  C  C   . CYS A 1 131 ? -33.162 -23.970 -24.304 1.00 56.65  ? 394  CYS A C   1 
ATOM   899  O  O   . CYS A 1 131 ? -33.169 -22.787 -23.867 1.00 55.48  ? 394  CYS A O   1 
ATOM   900  C  CB  . CYS A 1 131 ? -30.990 -25.413 -24.583 1.00 52.37  ? 394  CYS A CB  1 
ATOM   901  S  SG  . CYS A 1 131 ? -29.844 -26.124 -25.799 1.00 50.96  ? 394  CYS A SG  1 
ATOM   902  N  N   . THR A 1 132 ? -34.148 -24.832 -24.059 1.00 56.20  ? 395  THR A N   1 
ATOM   903  C  CA  . THR A 1 132 ? -35.487 -24.447 -23.521 1.00 60.07  ? 395  THR A CA  1 
ATOM   904  C  C   . THR A 1 132 ? -35.724 -25.052 -22.127 1.00 57.88  ? 395  THR A C   1 
ATOM   905  O  O   . THR A 1 132 ? -35.184 -26.159 -21.822 1.00 54.72  ? 395  THR A O   1 
ATOM   906  C  CB  . THR A 1 132 ? -36.579 -24.885 -24.514 1.00 56.08  ? 395  THR A CB  1 
ATOM   907  O  OG1 . THR A 1 132 ? -36.562 -26.312 -24.612 1.00 57.67  ? 395  THR A OG1 1 
ATOM   908  C  CG2 . THR A 1 132 ? -36.406 -24.295 -25.901 1.00 58.52  ? 395  THR A CG2 1 
ATOM   909  N  N   . ARG A 1 133 ? -36.562 -24.388 -21.327 1.00 62.64  ? 396  ARG A N   1 
ATOM   910  C  CA  . ARG A 1 133 ? -37.115 -24.960 -20.064 1.00 69.24  ? 396  ARG A CA  1 
ATOM   911  C  C   . ARG A 1 133 ? -37.513 -26.415 -20.341 1.00 70.08  ? 396  ARG A C   1 
ATOM   912  O  O   . ARG A 1 133 ? -37.133 -27.314 -19.560 1.00 68.54  ? 396  ARG A O   1 
ATOM   913  C  CB  . ARG A 1 133 ? -38.292 -24.131 -19.532 1.00 76.87  ? 396  ARG A CB  1 
ATOM   914  C  CG  . ARG A 1 133 ? -38.083 -22.629 -19.670 1.00 82.67  ? 396  ARG A CG  1 
ATOM   915  C  CD  . ARG A 1 133 ? -38.589 -21.729 -18.556 1.00 83.27  ? 396  ARG A CD  1 
ATOM   916  N  NE  . ARG A 1 133 ? -37.861 -20.455 -18.606 1.00 87.55  ? 396  ARG A NE  1 
ATOM   917  C  CZ  . ARG A 1 133 ? -37.904 -19.492 -17.682 1.00 88.59  ? 396  ARG A CZ  1 
ATOM   918  N  NH1 . ARG A 1 133 ? -38.676 -19.628 -16.617 1.00 83.98  ? 396  ARG A NH1 1 
ATOM   919  N  NH2 . ARG A 1 133 ? -37.174 -18.392 -17.829 1.00 82.40  ? 396  ARG A NH2 1 
ATOM   920  N  N   . GLU A 1 134 ? -38.224 -26.634 -21.440 1.00 66.13  ? 397  GLU A N   1 
ATOM   921  C  CA  . GLU A 1 134 ? -38.742 -27.989 -21.727 1.00 70.50  ? 397  GLU A CA  1 
ATOM   922  C  C   . GLU A 1 134 ? -37.577 -28.976 -21.804 1.00 76.44  ? 397  GLU A C   1 
ATOM   923  O  O   . GLU A 1 134 ? -37.659 -30.023 -21.146 1.00 89.45  ? 397  GLU A O   1 
ATOM   924  C  CB  . GLU A 1 134 ? -39.603 -27.931 -22.988 1.00 73.29  ? 397  GLU A CB  1 
ATOM   925  C  CG  . GLU A 1 134 ? -40.871 -27.114 -22.816 1.00 79.15  ? 397  GLU A CG  1 
ATOM   926  C  CD  . GLU A 1 134 ? -40.677 -25.628 -22.563 1.00 89.36  ? 397  GLU A CD  1 
ATOM   927  O  OE1 . GLU A 1 134 ? -39.640 -25.087 -22.987 1.00 93.16  ? 397  GLU A OE1 1 
ATOM   928  O  OE2 . GLU A 1 134 ? -41.562 -25.017 -21.934 1.00 98.20  ? 397  GLU A OE2 1 
ATOM   929  N  N   . GLU A 1 135 ? -36.534 -28.648 -22.567 0.50 80.47  ? 398  GLU A N   1 
ATOM   930  C  CA  . GLU A 1 135 ? -35.372 -29.562 -22.719 0.50 80.07  ? 398  GLU A CA  1 
ATOM   931  C  C   . GLU A 1 135 ? -34.743 -29.803 -21.346 0.50 76.72  ? 398  GLU A C   1 
ATOM   932  O  O   . GLU A 1 135 ? -34.449 -30.968 -21.029 0.50 73.59  ? 398  GLU A O   1 
ATOM   933  C  CB  . GLU A 1 135 ? -34.338 -28.960 -23.672 0.50 80.11  ? 398  GLU A CB  1 
ATOM   934  C  CG  . GLU A 1 135 ? -34.789 -28.908 -25.118 0.50 79.58  ? 398  GLU A CG  1 
ATOM   935  C  CD  . GLU A 1 135 ? -33.812 -28.206 -26.045 0.50 77.01  ? 398  GLU A CD  1 
ATOM   936  O  OE1 . GLU A 1 135 ? -33.598 -26.994 -25.865 0.50 70.64  ? 398  GLU A OE1 1 
ATOM   937  O  OE2 . GLU A 1 135 ? -33.260 -28.878 -26.935 0.50 75.49  ? 398  GLU A OE2 1 
ATOM   938  N  N   . PHE A 1 136 ? -34.552 -28.734 -20.571 0.50 75.30  ? 399  PHE A N   1 
ATOM   939  C  CA  . PHE A 1 136 ? -33.934 -28.847 -19.226 0.50 77.20  ? 399  PHE A CA  1 
ATOM   940  C  C   . PHE A 1 136 ? -34.859 -29.663 -18.318 0.50 78.90  ? 399  PHE A C   1 
ATOM   941  O  O   . PHE A 1 136 ? -34.361 -30.527 -17.574 0.50 74.87  ? 399  PHE A O   1 
ATOM   942  C  CB  . PHE A 1 136 ? -33.663 -27.443 -18.680 0.50 76.35  ? 399  PHE A CB  1 
ATOM   943  C  CG  . PHE A 1 136 ? -32.884 -27.374 -17.392 0.50 74.54  ? 399  PHE A CG  1 
ATOM   944  C  CD1 . PHE A 1 136 ? -31.505 -27.494 -17.389 0.50 73.67  ? 399  PHE A CD1 1 
ATOM   945  C  CD2 . PHE A 1 136 ? -33.528 -27.160 -16.184 0.50 73.95  ? 399  PHE A CD2 1 
ATOM   946  C  CE1 . PHE A 1 136 ? -30.788 -27.418 -16.206 0.50 73.32  ? 399  PHE A CE1 1 
ATOM   947  C  CE2 . PHE A 1 136 ? -32.810 -27.084 -15.002 0.50 73.66  ? 399  PHE A CE2 1 
ATOM   948  C  CZ  . PHE A 1 136 ? -31.442 -27.213 -15.015 0.50 73.19  ? 399  PHE A CZ  1 
ATOM   949  N  N   . THR A 1 137 ? -36.166 -29.404 -18.399 0.50 83.08  ? 400  THR A N   1 
ATOM   950  C  CA  . THR A 1 137 ? -37.153 -30.141 -17.567 0.50 85.76  ? 400  THR A CA  1 
ATOM   951  C  C   . THR A 1 137 ? -37.051 -31.635 -17.872 0.50 85.24  ? 400  THR A C   1 
ATOM   952  O  O   . THR A 1 137 ? -37.014 -32.427 -16.921 0.50 88.33  ? 400  THR A O   1 
ATOM   953  C  CB  . THR A 1 137 ? -38.577 -29.642 -17.833 0.50 87.04  ? 400  THR A CB  1 
ATOM   954  O  OG1 . THR A 1 137 ? -38.628 -28.247 -17.534 0.50 89.88  ? 400  THR A OG1 1 
ATOM   955  C  CG2 . THR A 1 137 ? -39.622 -30.384 -17.029 0.50 87.74  ? 400  THR A CG2 1 
ATOM   956  N  N   . ARG A 1 138 ? -37.001 -31.991 -19.154 0.50 87.92  ? 401  ARG A N   1 
ATOM   957  C  CA  . ARG A 1 138 ? -36.946 -33.421 -19.549 0.50 93.52  ? 401  ARG A CA  1 
ATOM   958  C  C   . ARG A 1 138 ? -35.634 -34.022 -19.046 0.50 91.79  ? 401  ARG A C   1 
ATOM   959  O  O   . ARG A 1 138 ? -35.643 -35.183 -18.612 0.50 93.71  ? 401  ARG A O   1 
ATOM   960  C  CB  . ARG A 1 138 ? -37.069 -33.536 -21.069 0.50 100.56 ? 401  ARG A CB  1 
ATOM   961  C  CG  . ARG A 1 138 ? -37.334 -34.944 -21.581 0.50 105.03 ? 401  ARG A CG  1 
ATOM   962  C  CD  . ARG A 1 138 ? -38.241 -34.887 -22.796 0.50 106.72 ? 401  ARG A CD  1 
ATOM   963  N  NE  . ARG A 1 138 ? -37.884 -33.790 -23.683 0.50 107.83 ? 401  ARG A NE  1 
ATOM   964  C  CZ  . ARG A 1 138 ? -37.071 -33.898 -24.727 0.50 106.59 ? 401  ARG A CZ  1 
ATOM   965  N  NH1 . ARG A 1 138 ? -36.532 -35.067 -25.028 0.50 107.41 ? 401  ARG A NH1 1 
ATOM   966  N  NH2 . ARG A 1 138 ? -36.804 -32.839 -25.470 0.50 103.62 ? 401  ARG A NH2 1 
ATOM   967  N  N   . LYS A 1 139 ? -34.554 -33.246 -19.096 0.50 92.08  ? 402  LYS A N   1 
ATOM   968  C  CA  . LYS A 1 139 ? -33.231 -33.748 -18.650 0.50 94.01  ? 402  LYS A CA  1 
ATOM   969  C  C   . LYS A 1 139 ? -33.320 -34.139 -17.174 0.50 100.14 ? 402  LYS A C   1 
ATOM   970  O  O   . LYS A 1 139 ? -32.879 -35.251 -16.833 0.50 102.41 ? 402  LYS A O   1 
ATOM   971  C  CB  . LYS A 1 139 ? -32.165 -32.671 -18.864 0.50 91.65  ? 402  LYS A CB  1 
ATOM   972  C  CG  . LYS A 1 139 ? -30.872 -33.155 -19.504 0.50 90.91  ? 402  LYS A CG  1 
ATOM   973  C  CD  . LYS A 1 139 ? -29.960 -32.026 -19.927 0.50 90.44  ? 402  LYS A CD  1 
ATOM   974  C  CE  . LYS A 1 139 ? -28.787 -32.495 -20.762 0.50 89.93  ? 402  LYS A CE  1 
ATOM   975  N  NZ  . LYS A 1 139 ? -29.236 -33.152 -22.012 0.50 87.60  ? 402  LYS A NZ  1 
ATOM   976  N  N   . VAL A 1 140 ? -33.875 -33.258 -16.338 0.50 104.79 ? 403  VAL A N   1 
ATOM   977  C  CA  . VAL A 1 140 ? -33.942 -33.530 -14.871 0.50 107.85 ? 403  VAL A CA  1 
ATOM   978  C  C   . VAL A 1 140 ? -34.977 -34.630 -14.621 0.50 110.36 ? 403  VAL A C   1 
ATOM   979  O  O   . VAL A 1 140 ? -34.776 -35.424 -13.683 0.50 109.69 ? 403  VAL A O   1 
ATOM   980  C  CB  . VAL A 1 140 ? -34.270 -32.254 -14.075 0.50 109.35 ? 403  VAL A CB  1 
ATOM   981  C  CG1 . VAL A 1 140 ? -33.274 -31.141 -14.359 0.50 108.59 ? 403  VAL A CG1 1 
ATOM   982  C  CG2 . VAL A 1 140 ? -35.690 -31.777 -14.333 0.50 109.86 ? 403  VAL A CG2 1 
ATOM   983  N  N   . ARG A 1 141 ? -36.043 -34.663 -15.424 0.50 111.66 ? 404  ARG A N   1 
ATOM   984  C  CA  . ARG A 1 141 ? -37.088 -35.710 -15.282 0.50 112.01 ? 404  ARG A CA  1 
ATOM   985  C  C   . ARG A 1 141 ? -36.489 -37.047 -15.715 0.50 112.75 ? 404  ARG A C   1 
ATOM   986  O  O   . ARG A 1 141 ? -36.801 -38.070 -15.083 0.50 118.42 ? 404  ARG A O   1 
ATOM   987  C  CB  . ARG A 1 141 ? -38.314 -35.342 -16.119 0.50 110.04 ? 404  ARG A CB  1 
ATOM   988  C  CG  . ARG A 1 141 ? -39.617 -35.944 -15.616 0.50 110.89 ? 404  ARG A CG  1 
ATOM   989  C  CD  . ARG A 1 141 ? -40.776 -35.003 -15.882 0.50 112.25 ? 404  ARG A CD  1 
ATOM   990  N  NE  . ARG A 1 141 ? -40.665 -33.773 -15.110 0.50 111.94 ? 404  ARG A NE  1 
ATOM   991  C  CZ  . ARG A 1 141 ? -41.489 -32.738 -15.223 0.50 110.30 ? 404  ARG A CZ  1 
ATOM   992  N  NH1 . ARG A 1 141 ? -42.486 -32.778 -16.089 0.50 111.03 ? 404  ARG A NH1 1 
ATOM   993  N  NH2 . ARG A 1 141 ? -41.309 -31.664 -14.476 0.50 108.25 ? 404  ARG A NH2 1 
ATOM   994  N  N   . SER A 1 142 ? -35.652 -37.025 -16.751 0.50 113.39 ? 405  SER A N   1 
ATOM   995  C  CA  . SER A 1 142 ? -34.981 -38.263 -17.216 0.50 115.23 ? 405  SER A CA  1 
ATOM   996  C  C   . SER A 1 142 ? -33.811 -38.568 -16.281 0.50 115.63 ? 405  SER A C   1 
ATOM   997  O  O   . SER A 1 142 ? -33.168 -39.618 -16.469 0.50 114.80 ? 405  SER A O   1 
ATOM   998  C  CB  . SER A 1 142 ? -34.516 -38.112 -18.633 0.50 116.41 ? 405  SER A CB  1 
ATOM   999  O  OG  . SER A 1 142 ? -33.673 -36.977 -18.762 0.50 118.49 ? 405  SER A OG  1 
ATOM   1000 N  N   . ASN A 1 143 ? -33.548 -37.672 -15.328 0.50 114.26 ? 406  ASN A N   1 
ATOM   1001 C  CA  . ASN A 1 143 ? -32.426 -37.858 -14.367 0.50 114.41 ? 406  ASN A CA  1 
ATOM   1002 C  C   . ASN A 1 143 ? -31.085 -37.720 -15.091 0.50 111.62 ? 406  ASN A C   1 
ATOM   1003 O  O   . ASN A 1 143 ? -30.745 -38.618 -15.882 0.50 112.85 ? 406  ASN A O   1 
ATOM   1004 C  CB  . ASN A 1 143 ? -32.530 -39.175 -13.593 0.50 115.56 ? 406  ASN A CB  1 
ATOM   1005 C  CG  . ASN A 1 143 ? -33.319 -39.037 -12.308 0.50 116.42 ? 406  ASN A CG  1 
ATOM   1006 O  OD1 . ASN A 1 143 ? -33.919 -37.995 -12.052 0.50 116.81 ? 406  ASN A OD1 1 
ATOM   1007 N  ND2 . ASN A 1 143 ? -33.320 -40.078 -11.493 0.50 116.21 ? 406  ASN A ND2 1 
ATOM   1008 N  N   . ALA A 1 144 ? -30.357 -36.639 -14.818 0.50 108.98 ? 407  ALA A N   1 
ATOM   1009 C  CA  . ALA A 1 144 ? -29.019 -36.416 -15.412 0.50 109.69 ? 407  ALA A CA  1 
ATOM   1010 C  C   . ALA A 1 144 ? -28.143 -35.653 -14.411 0.50 110.49 ? 407  ALA A C   1 
ATOM   1011 O  O   . ALA A 1 144 ? -28.707 -34.940 -13.557 0.50 106.72 ? 407  ALA A O   1 
ATOM   1012 C  CB  . ALA A 1 144 ? -29.151 -35.671 -16.718 0.50 108.60 ? 407  ALA A CB  1 
ATOM   1013 N  N   . ALA A 1 145 ? -26.818 -35.807 -14.520 0.50 110.25 ? 408  ALA A N   1 
ATOM   1014 C  CA  . ALA A 1 145 ? -25.801 -35.191 -13.635 0.50 109.85 ? 408  ALA A CA  1 
ATOM   1015 C  C   . ALA A 1 145 ? -25.515 -33.753 -14.087 0.50 109.23 ? 408  ALA A C   1 
ATOM   1016 O  O   . ALA A 1 145 ? -24.648 -33.567 -14.964 0.50 107.31 ? 408  ALA A O   1 
ATOM   1017 C  CB  . ALA A 1 145 ? -24.548 -36.032 -13.642 0.50 109.15 ? 408  ALA A CB  1 
ATOM   1018 N  N   . LEU A 1 146 ? -26.208 -32.777 -13.491 0.50 109.46 ? 409  LEU A N   1 
ATOM   1019 C  CA  . LEU A 1 146 ? -26.147 -31.340 -13.874 0.50 109.67 ? 409  LEU A CA  1 
ATOM   1020 C  C   . LEU A 1 146 ? -25.228 -30.584 -12.908 0.50 108.54 ? 409  LEU A C   1 
ATOM   1021 O  O   . LEU A 1 146 ? -24.815 -29.457 -13.245 0.50 105.93 ? 409  LEU A O   1 
ATOM   1022 C  CB  . LEU A 1 146 ? -27.569 -30.768 -13.859 0.50 109.88 ? 409  LEU A CB  1 
ATOM   1023 C  CG  . LEU A 1 146 ? -28.598 -31.567 -14.658 0.50 110.53 ? 409  LEU A CG  1 
ATOM   1024 C  CD1 . LEU A 1 146 ? -29.900 -30.795 -14.796 0.50 111.36 ? 409  LEU A CD1 1 
ATOM   1025 C  CD2 . LEU A 1 146 ? -28.052 -31.937 -16.029 0.50 111.80 ? 409  LEU A CD2 1 
ATOM   1026 N  N   . GLY A 1 147 ? -24.915 -31.195 -11.760 0.50 109.22 ? 410  GLY A N   1 
ATOM   1027 C  CA  . GLY A 1 147 ? -24.072 -30.603 -10.702 0.50 108.74 ? 410  GLY A CA  1 
ATOM   1028 C  C   . GLY A 1 147 ? -24.795 -29.485 -9.969  0.50 107.97 ? 410  GLY A C   1 
ATOM   1029 O  O   . GLY A 1 147 ? -24.295 -28.343 -9.997  0.50 104.20 ? 410  GLY A O   1 
ATOM   1030 N  N   . ALA A 1 148 ? -25.922 -29.809 -9.324  1.00 108.63 ? 411  ALA A N   1 
ATOM   1031 C  CA  . ALA A 1 148 ? -26.787 -28.837 -8.609  1.00 109.49 ? 411  ALA A CA  1 
ATOM   1032 C  C   . ALA A 1 148 ? -26.615 -28.956 -7.080  1.00 120.26 ? 411  ALA A C   1 
ATOM   1033 O  O   . ALA A 1 148 ? -25.629 -29.578 -6.623  1.00 108.95 ? 411  ALA A O   1 
ATOM   1034 C  CB  . ALA A 1 148 ? -28.218 -29.055 -9.042  1.00 101.98 ? 411  ALA A CB  1 
ATOM   1035 N  N   . ILE A 1 149 ? -27.519 -28.325 -6.317  1.00 130.12 ? 412  ILE A N   1 
ATOM   1036 C  CA  . ILE A 1 149 ? -27.593 -28.368 -4.824  1.00 131.47 ? 412  ILE A CA  1 
ATOM   1037 C  C   . ILE A 1 149 ? -29.075 -28.320 -4.405  1.00 143.89 ? 412  ILE A C   1 
ATOM   1038 O  O   . ILE A 1 149 ? -29.858 -27.598 -5.066  1.00 138.20 ? 412  ILE A O   1 
ATOM   1039 C  CB  . ILE A 1 149 ? -26.755 -27.224 -4.213  1.00 129.62 ? 412  ILE A CB  1 
ATOM   1040 C  CG1 . ILE A 1 149 ? -27.152 -25.854 -4.773  1.00 131.90 ? 412  ILE A CG1 1 
ATOM   1041 C  CG2 . ILE A 1 149 ? -25.269 -27.487 -4.403  1.00 128.66 ? 412  ILE A CG2 1 
ATOM   1042 C  CD1 . ILE A 1 149 ? -26.582 -24.678 -4.014  1.00 127.94 ? 412  ILE A CD1 1 
ATOM   1043 N  N   . LYS A 1 155 ? -35.480 -24.121 -0.680  0.50 93.23  ? 418  LYS A N   1 
ATOM   1044 C  CA  . LYS A 1 155 ? -36.959 -24.282 -0.662  0.50 89.93  ? 418  LYS A CA  1 
ATOM   1045 C  C   . LYS A 1 155 ? -37.314 -25.707 -1.090  0.50 89.48  ? 418  LYS A C   1 
ATOM   1046 O  O   . LYS A 1 155 ? -37.981 -26.403 -0.305  0.50 86.20  ? 418  LYS A O   1 
ATOM   1047 C  CB  . LYS A 1 155 ? -37.614 -23.247 -1.582  0.50 91.14  ? 418  LYS A CB  1 
ATOM   1048 C  CG  . LYS A 1 155 ? -39.135 -23.181 -1.534  0.50 90.73  ? 418  LYS A CG  1 
ATOM   1049 C  CD  . LYS A 1 155 ? -39.821 -24.338 -2.227  0.50 89.50  ? 418  LYS A CD  1 
ATOM   1050 C  CE  . LYS A 1 155 ? -41.330 -24.224 -2.226  0.50 88.69  ? 418  LYS A CE  1 
ATOM   1051 N  NZ  . LYS A 1 155 ? -41.966 -25.373 -2.915  0.50 85.15  ? 418  LYS A NZ  1 
ATOM   1052 N  N   . TRP A 1 156 ? -36.892 -26.112 -2.292  0.50 93.20  ? 419  TRP A N   1 
ATOM   1053 C  CA  . TRP A 1 156 ? -37.174 -27.480 -2.804  0.50 92.05  ? 419  TRP A CA  1 
ATOM   1054 C  C   . TRP A 1 156 ? -36.014 -28.410 -2.438  0.50 96.10  ? 419  TRP A C   1 
ATOM   1055 O  O   . TRP A 1 156 ? -34.897 -27.902 -2.233  0.50 97.68  ? 419  TRP A O   1 
ATOM   1056 C  CB  . TRP A 1 156 ? -37.399 -27.457 -4.319  0.50 87.73  ? 419  TRP A CB  1 
ATOM   1057 C  CG  . TRP A 1 156 ? -38.093 -26.228 -4.815  0.50 85.02  ? 419  TRP A CG  1 
ATOM   1058 C  CD1 . TRP A 1 156 ? -39.411 -26.103 -5.140  0.50 83.55  ? 419  TRP A CD1 1 
ATOM   1059 C  CD2 . TRP A 1 156 ? -37.498 -24.939 -5.045  0.50 81.50  ? 419  TRP A CD2 1 
ATOM   1060 N  NE1 . TRP A 1 156 ? -39.676 -24.827 -5.556  0.50 82.54  ? 419  TRP A NE1 1 
ATOM   1061 C  CE2 . TRP A 1 156 ? -38.524 -24.090 -5.507  0.50 79.30  ? 419  TRP A CE2 1 
ATOM   1062 C  CE3 . TRP A 1 156 ? -36.206 -24.421 -4.907  0.50 79.94  ? 419  TRP A CE3 1 
ATOM   1063 C  CZ2 . TRP A 1 156 ? -38.296 -22.754 -5.830  0.50 78.44  ? 419  TRP A CZ2 1 
ATOM   1064 C  CZ3 . TRP A 1 156 ? -35.982 -23.101 -5.225  0.50 79.76  ? 419  TRP A CZ3 1 
ATOM   1065 C  CH2 . TRP A 1 156 ? -37.013 -22.281 -5.680  0.50 77.76  ? 419  TRP A CH2 1 
ATOM   1066 N  N   . LYS A 1 157 ? -36.274 -29.717 -2.374  0.50 98.15  ? 420  LYS A N   1 
ATOM   1067 C  CA  . LYS A 1 157 ? -35.216 -30.702 -2.032  0.50 100.40 ? 420  LYS A CA  1 
ATOM   1068 C  C   . LYS A 1 157 ? -34.732 -31.388 -3.310  0.50 100.12 ? 420  LYS A C   1 
ATOM   1069 O  O   . LYS A 1 157 ? -33.507 -31.518 -3.480  0.50 103.76 ? 420  LYS A O   1 
ATOM   1070 C  CB  . LYS A 1 157 ? -35.762 -31.724 -1.031  0.50 105.54 ? 420  LYS A CB  1 
ATOM   1071 C  CG  . LYS A 1 157 ? -35.360 -33.175 -1.266  0.50 105.91 ? 420  LYS A CG  1 
ATOM   1072 C  CD  . LYS A 1 157 ? -36.345 -33.938 -2.126  0.50 107.71 ? 420  LYS A CD  1 
ATOM   1073 C  CE  . LYS A 1 157 ? -37.781 -33.769 -1.676  0.50 107.11 ? 420  LYS A CE  1 
ATOM   1074 N  NZ  . LYS A 1 157 ? -38.723 -34.504 -2.552  0.50 105.48 ? 420  LYS A NZ  1 
ATOM   1075 N  N   . SER A 1 158 ? -35.664 -31.808 -4.167  0.50 97.68  ? 421  SER A N   1 
ATOM   1076 C  CA  . SER A 1 158 ? -35.295 -32.519 -5.416  0.50 94.31  ? 421  SER A CA  1 
ATOM   1077 C  C   . SER A 1 158 ? -35.331 -31.541 -6.590  0.50 95.11  ? 421  SER A C   1 
ATOM   1078 O  O   . SER A 1 158 ? -36.202 -30.651 -6.591  0.50 90.11  ? 421  SER A O   1 
ATOM   1079 C  CB  . SER A 1 158 ? -36.206 -33.688 -5.657  0.50 91.94  ? 421  SER A CB  1 
ATOM   1080 O  OG  . SER A 1 158 ? -37.526 -33.249 -5.935  0.50 91.49  ? 421  SER A OG  1 
ATOM   1081 N  N   . ALA A 1 159 ? -34.422 -31.713 -7.551  0.50 96.58  ? 422  ALA A N   1 
ATOM   1082 C  CA  . ALA A 1 159 ? -34.411 -30.846 -8.750  0.50 98.21  ? 422  ALA A CA  1 
ATOM   1083 C  C   . ALA A 1 159 ? -35.728 -31.025 -9.505  0.50 98.05  ? 422  ALA A C   1 
ATOM   1084 O  O   . ALA A 1 159 ? -36.271 -30.017 -9.997  0.50 94.62  ? 422  ALA A O   1 
ATOM   1085 C  CB  . ALA A 1 159 ? -33.227 -31.200 -9.612  0.50 98.26  ? 422  ALA A CB  1 
ATOM   1086 N  N   . ARG A 1 160 ? -36.236 -32.257 -9.550  0.50 100.17 ? 423  ARG A N   1 
ATOM   1087 C  CA  . ARG A 1 160 ? -37.488 -32.548 -10.293 0.50 102.00 ? 423  ARG A CA  1 
ATOM   1088 C  C   . ARG A 1 160 ? -38.612 -31.632 -9.796  0.50 105.38 ? 423  ARG A C   1 
ATOM   1089 O  O   . ARG A 1 160 ? -39.338 -31.090 -10.646 0.50 104.74 ? 423  ARG A O   1 
ATOM   1090 C  CB  . ARG A 1 160 ? -37.848 -34.023 -10.105 0.50 102.65 ? 423  ARG A CB  1 
ATOM   1091 C  CG  . ARG A 1 160 ? -38.935 -34.533 -11.038 0.50 106.26 ? 423  ARG A CG  1 
ATOM   1092 C  CD  . ARG A 1 160 ? -39.210 -36.003 -10.780 0.50 108.35 ? 423  ARG A CD  1 
ATOM   1093 N  NE  . ARG A 1 160 ? -38.046 -36.841 -11.036 0.50 108.63 ? 423  ARG A NE  1 
ATOM   1094 C  CZ  . ARG A 1 160 ? -37.870 -37.566 -12.133 0.50 108.06 ? 423  ARG A CZ  1 
ATOM   1095 N  NH1 . ARG A 1 160 ? -36.778 -38.296 -12.278 0.50 105.63 ? 423  ARG A NH1 1 
ATOM   1096 N  NH2 . ARG A 1 160 ? -38.793 -37.569 -13.077 0.50 109.01 ? 423  ARG A NH2 1 
ATOM   1097 N  N   . GLU A 1 161 ? -38.735 -31.452 -8.480  0.50 109.51 ? 424  GLU A N   1 
ATOM   1098 C  CA  . GLU A 1 161 ? -39.850 -30.645 -7.914  0.50 113.47 ? 424  GLU A CA  1 
ATOM   1099 C  C   . GLU A 1 161 ? -39.710 -29.174 -8.309  0.50 113.21 ? 424  GLU A C   1 
ATOM   1100 O  O   . GLU A 1 161 ? -40.739 -28.561 -8.652  0.50 108.64 ? 424  GLU A O   1 
ATOM   1101 C  CB  . GLU A 1 161 ? -39.871 -30.760 -6.390  0.50 118.03 ? 424  GLU A CB  1 
ATOM   1102 C  CG  . GLU A 1 161 ? -40.338 -32.113 -5.886  0.50 118.11 ? 424  GLU A CG  1 
ATOM   1103 C  CD  . GLU A 1 161 ? -40.414 -32.222 -4.373  0.50 116.42 ? 424  GLU A CD  1 
ATOM   1104 O  OE1 . GLU A 1 161 ? -40.017 -31.255 -3.692  0.50 116.56 ? 424  GLU A OE1 1 
ATOM   1105 O  OE2 . GLU A 1 161 ? -40.873 -33.272 -3.880  0.50 106.05 ? 424  GLU A OE2 1 
ATOM   1106 N  N   . ALA A 1 162 ? -38.491 -28.631 -8.263  1.00 113.91 ? 425  ALA A N   1 
ATOM   1107 C  CA  . ALA A 1 162 ? -38.287 -27.190 -8.539  1.00 106.85 ? 425  ALA A CA  1 
ATOM   1108 C  C   . ALA A 1 162 ? -38.723 -26.852 -9.963  1.00 104.81 ? 425  ALA A C   1 
ATOM   1109 O  O   . ALA A 1 162 ? -39.106 -25.695 -10.195 1.00 98.35  ? 425  ALA A O   1 
ATOM   1110 C  CB  . ALA A 1 162 ? -36.845 -26.827 -8.312  1.00 105.05 ? 425  ALA A CB  1 
ATOM   1111 N  N   . VAL A 1 163 ? -38.680 -27.828 -10.869 0.50 104.10 ? 426  VAL A N   1 
ATOM   1112 C  CA  . VAL A 1 163 ? -38.998 -27.546 -12.300 0.50 105.41 ? 426  VAL A CA  1 
ATOM   1113 C  C   . VAL A 1 163 ? -40.497 -27.261 -12.461 0.50 106.39 ? 426  VAL A C   1 
ATOM   1114 O  O   . VAL A 1 163 ? -40.890 -26.794 -13.546 0.50 104.64 ? 426  VAL A O   1 
ATOM   1115 C  CB  . VAL A 1 163 ? -38.543 -28.706 -13.204 0.50 104.93 ? 426  VAL A CB  1 
ATOM   1116 C  CG1 . VAL A 1 163 ? -38.351 -28.241 -14.635 0.50 105.54 ? 426  VAL A CG1 1 
ATOM   1117 C  CG2 . VAL A 1 163 ? -37.265 -29.342 -12.687 0.50 105.29 ? 426  VAL A CG2 1 
ATOM   1118 N  N   . GLU A 1 164 ? -41.300 -27.532 -11.429 0.50 108.75 ? 427  GLU A N   1 
ATOM   1119 C  CA  . GLU A 1 164 ? -42.772 -27.338 -11.537 0.50 108.38 ? 427  GLU A CA  1 
ATOM   1120 C  C   . GLU A 1 164 ? -43.194 -26.098 -10.741 0.50 104.22 ? 427  GLU A C   1 
ATOM   1121 O  O   . GLU A 1 164 ? -44.173 -25.445 -11.146 0.50 98.99  ? 427  GLU A O   1 
ATOM   1122 C  CB  . GLU A 1 164 ? -43.497 -28.594 -11.055 0.50 110.04 ? 427  GLU A CB  1 
ATOM   1123 C  CG  . GLU A 1 164 ? -43.185 -29.823 -11.888 0.50 111.65 ? 427  GLU A CG  1 
ATOM   1124 C  CD  . GLU A 1 164 ? -42.312 -30.848 -11.188 0.50 115.93 ? 427  GLU A CD  1 
ATOM   1125 O  OE1 . GLU A 1 164 ? -42.065 -30.680 -9.980  0.50 119.25 ? 427  GLU A OE1 1 
ATOM   1126 O  OE2 . GLU A 1 164 ? -41.884 -31.812 -11.852 0.50 117.23 ? 427  GLU A OE2 1 
ATOM   1127 N  N   . ASP A 1 165 ? -42.480 -25.786 -9.663  0.50 103.59 ? 428  ASP A N   1 
ATOM   1128 C  CA  . ASP A 1 165 ? -42.795 -24.616 -8.801  0.50 103.44 ? 428  ASP A CA  1 
ATOM   1129 C  C   . ASP A 1 165 ? -42.437 -23.324 -9.548  0.50 101.99 ? 428  ASP A C   1 
ATOM   1130 O  O   . ASP A 1 165 ? -41.247 -22.960 -9.573  0.50 98.53  ? 428  ASP A O   1 
ATOM   1131 C  CB  . ASP A 1 165 ? -42.069 -24.730 -7.457  0.50 104.06 ? 428  ASP A CB  1 
ATOM   1132 C  CG  . ASP A 1 165 ? -42.228 -23.512 -6.564  0.50 104.76 ? 428  ASP A CG  1 
ATOM   1133 O  OD1 . ASP A 1 165 ? -42.549 -22.435 -7.103  0.50 104.36 ? 428  ASP A OD1 1 
ATOM   1134 O  OD2 . ASP A 1 165 ? -42.026 -23.651 -5.336  0.50 102.55 ? 428  ASP A OD2 1 
ATOM   1135 N  N   . SER A 1 166 ? -43.441 -22.676 -10.142 0.50 100.24 ? 429  SER A N   1 
ATOM   1136 C  CA  . SER A 1 166 ? -43.218 -21.462 -10.971 0.50 100.16 ? 429  SER A CA  1 
ATOM   1137 C  C   . SER A 1 166 ? -42.365 -20.424 -10.244 0.50 98.12  ? 429  SER A C   1 
ATOM   1138 O  O   . SER A 1 166 ? -41.743 -19.596 -10.927 0.50 101.07 ? 429  SER A O   1 
ATOM   1139 C  CB  . SER A 1 166 ? -44.537 -20.875 -11.372 0.50 105.11 ? 429  SER A CB  1 
ATOM   1140 O  OG  . SER A 1 166 ? -45.351 -21.854 -12.002 0.50 107.84 ? 429  SER A OG  1 
ATOM   1141 N  N   . GLY A 1 167 ? -42.359 -20.453 -8.914  1.00 97.80  ? 430  GLY A N   1 
ATOM   1142 C  CA  . GLY A 1 167 ? -41.518 -19.512 -8.155  1.00 88.00  ? 430  GLY A CA  1 
ATOM   1143 C  C   . GLY A 1 167 ? -40.074 -19.698 -8.557  1.00 87.27  ? 430  GLY A C   1 
ATOM   1144 O  O   . GLY A 1 167 ? -39.359 -18.700 -8.690  1.00 78.04  ? 430  GLY A O   1 
ATOM   1145 N  N   . PHE A 1 168 ? -39.669 -20.950 -8.750  1.00 88.09  ? 431  PHE A N   1 
ATOM   1146 C  CA  . PHE A 1 168 ? -38.296 -21.223 -9.228  1.00 91.60  ? 431  PHE A CA  1 
ATOM   1147 C  C   . PHE A 1 168 ? -38.105 -20.487 -10.550 1.00 80.21  ? 431  PHE A C   1 
ATOM   1148 O  O   . PHE A 1 168 ? -37.133 -19.738 -10.682 1.00 78.41  ? 431  PHE A O   1 
ATOM   1149 C  CB  . PHE A 1 168 ? -38.104 -22.732 -9.382  1.00 95.42  ? 431  PHE A CB  1 
ATOM   1150 C  CG  . PHE A 1 168 ? -36.825 -23.168 -10.051 1.00 94.77  ? 431  PHE A CG  1 
ATOM   1151 C  CD1 . PHE A 1 168 ? -35.702 -23.477 -9.302  1.00 94.88  ? 431  PHE A CD1 1 
ATOM   1152 C  CD2 . PHE A 1 168 ? -36.750 -23.293 -11.428 1.00 95.67  ? 431  PHE A CD2 1 
ATOM   1153 C  CE1 . PHE A 1 168 ? -34.530 -23.889 -9.915  1.00 85.08  ? 431  PHE A CE1 1 
ATOM   1154 C  CE2 . PHE A 1 168 ? -35.577 -23.702 -12.040 1.00 94.27  ? 431  PHE A CE2 1 
ATOM   1155 C  CZ  . PHE A 1 168 ? -34.469 -23.999 -11.283 1.00 87.98  ? 431  PHE A CZ  1 
ATOM   1156 N  N   . TRP A 1 169 ? -39.043 -20.664 -11.476 1.00 70.44  ? 432  TRP A N   1 
ATOM   1157 C  CA  . TRP A 1 169 ? -38.900 -20.047 -12.816 1.00 70.09  ? 432  TRP A CA  1 
ATOM   1158 C  C   . TRP A 1 169 ? -38.991 -18.527 -12.695 1.00 78.03  ? 432  TRP A C   1 
ATOM   1159 O  O   . TRP A 1 169 ? -38.483 -17.836 -13.591 1.00 88.25  ? 432  TRP A O   1 
ATOM   1160 C  CB  . TRP A 1 169 ? -39.915 -20.645 -13.792 1.00 64.68  ? 432  TRP A CB  1 
ATOM   1161 C  CG  . TRP A 1 169 ? -39.645 -22.088 -14.082 1.00 69.88  ? 432  TRP A CG  1 
ATOM   1162 C  CD1 . TRP A 1 169 ? -40.426 -23.156 -13.753 1.00 78.38  ? 432  TRP A CD1 1 
ATOM   1163 C  CD2 . TRP A 1 169 ? -38.485 -22.628 -14.738 1.00 68.63  ? 432  TRP A CD2 1 
ATOM   1164 N  NE1 . TRP A 1 169 ? -39.841 -24.319 -14.172 1.00 79.28  ? 432  TRP A NE1 1 
ATOM   1165 C  CE2 . TRP A 1 169 ? -38.649 -24.028 -14.779 1.00 73.87  ? 432  TRP A CE2 1 
ATOM   1166 C  CE3 . TRP A 1 169 ? -37.331 -22.070 -15.297 1.00 67.95  ? 432  TRP A CE3 1 
ATOM   1167 C  CZ2 . TRP A 1 169 ? -37.704 -24.870 -15.358 1.00 65.82  ? 432  TRP A CZ2 1 
ATOM   1168 C  CZ3 . TRP A 1 169 ? -36.398 -22.903 -15.870 1.00 65.53  ? 432  TRP A CZ3 1 
ATOM   1169 C  CH2 . TRP A 1 169 ? -36.584 -24.284 -15.899 1.00 58.83  ? 432  TRP A CH2 1 
ATOM   1170 N  N   . GLU A 1 170 ? -39.588 -18.023 -11.619 1.00 78.23  ? 433  GLU A N   1 
ATOM   1171 C  CA  . GLU A 1 170 ? -39.591 -16.552 -11.419 1.00 84.92  ? 433  GLU A CA  1 
ATOM   1172 C  C   . GLU A 1 170 ? -38.205 -16.155 -10.910 1.00 79.51  ? 433  GLU A C   1 
ATOM   1173 O  O   . GLU A 1 170 ? -37.735 -15.063 -11.264 1.00 67.88  ? 433  GLU A O   1 
ATOM   1174 C  CB  . GLU A 1 170 ? -40.729 -16.156 -10.481 1.00 100.36 ? 433  GLU A CB  1 
ATOM   1175 C  CG  . GLU A 1 170 ? -42.084 -16.647 -10.957 1.00 116.11 ? 433  GLU A CG  1 
ATOM   1176 C  CD  . GLU A 1 170 ? -43.191 -16.619 -9.917  1.00 127.22 ? 433  GLU A CD  1 
ATOM   1177 O  OE1 . GLU A 1 170 ? -42.991 -15.988 -8.860  1.00 129.34 ? 433  GLU A OE1 1 
ATOM   1178 O  OE2 . GLU A 1 170 ? -44.247 -17.236 -10.162 1.00 115.27 ? 433  GLU A OE2 1 
ATOM   1179 N  N   . LEU A 1 171 ? -37.582 -17.022 -10.111 1.00 86.22  ? 434  LEU A N   1 
ATOM   1180 C  CA  . LEU A 1 171 ? -36.200 -16.763 -9.640  1.00 88.78  ? 434  LEU A CA  1 
ATOM   1181 C  C   . LEU A 1 171 ? -35.288 -16.747 -10.863 1.00 81.09  ? 434  LEU A C   1 
ATOM   1182 O  O   . LEU A 1 171 ? -34.435 -15.852 -10.948 1.00 72.34  ? 434  LEU A O   1 
ATOM   1183 C  CB  . LEU A 1 171 ? -35.794 -17.877 -8.677  1.00 94.03  ? 434  LEU A CB  1 
ATOM   1184 C  CG  . LEU A 1 171 ? -36.619 -17.975 -7.396  1.00 97.83  ? 434  LEU A CG  1 
ATOM   1185 C  CD1 . LEU A 1 171 ? -36.089 -19.081 -6.498  1.00 90.20  ? 434  LEU A CD1 1 
ATOM   1186 C  CD2 . LEU A 1 171 ? -36.625 -16.649 -6.654  1.00 96.08  ? 434  LEU A CD2 1 
ATOM   1187 N  N   . VAL A 1 172 ? -35.496 -17.695 -11.778 1.00 74.40  ? 435  VAL A N   1 
ATOM   1188 C  CA  . VAL A 1 172 ? -34.698 -17.742 -13.034 1.00 72.12  ? 435  VAL A CA  1 
ATOM   1189 C  C   . VAL A 1 172 ? -34.987 -16.472 -13.829 1.00 70.44  ? 435  VAL A C   1 
ATOM   1190 O  O   . VAL A 1 172 ? -34.029 -15.840 -14.294 1.00 66.86  ? 435  VAL A O   1 
ATOM   1191 C  CB  . VAL A 1 172 ? -35.019 -19.007 -13.847 1.00 75.20  ? 435  VAL A CB  1 
ATOM   1192 C  CG1 . VAL A 1 172 ? -34.260 -19.043 -15.162 1.00 72.46  ? 435  VAL A CG1 1 
ATOM   1193 C  CG2 . VAL A 1 172 ? -34.758 -20.270 -13.042 1.00 73.60  ? 435  VAL A CG2 1 
ATOM   1194 N  N   . ASP A 1 173 ? -36.266 -16.105 -13.943 1.00 79.51  ? 436  ASP A N   1 
ATOM   1195 C  CA  . ASP A 1 173 ? -36.645 -14.879 -14.689 1.00 74.16  ? 436  ASP A CA  1 
ATOM   1196 C  C   . ASP A 1 173 ? -35.935 -13.693 -14.050 1.00 66.75  ? 436  ASP A C   1 
ATOM   1197 O  O   . ASP A 1 173 ? -35.344 -12.890 -14.786 1.00 66.57  ? 436  ASP A O   1 
ATOM   1198 C  CB  . ASP A 1 173 ? -38.158 -14.674 -14.709 1.00 90.97  ? 436  ASP A CB  1 
ATOM   1199 C  CG  . ASP A 1 173 ? -38.902 -15.709 -15.533 1.00 104.83 ? 436  ASP A CG  1 
ATOM   1200 O  OD1 . ASP A 1 173 ? -38.270 -16.317 -16.417 1.00 105.73 ? 436  ASP A OD1 1 
ATOM   1201 O  OD2 . ASP A 1 173 ? -40.107 -15.901 -15.279 1.00 114.82 ? 436  ASP A OD2 1 
ATOM   1202 N  N   . LYS A 1 174 ? -35.998 -13.601 -12.722 1.00 68.79  ? 437  LYS A N   1 
ATOM   1203 C  CA  . LYS A 1 174 ? -35.378 -12.431 -12.028 1.00 67.74  ? 437  LYS A CA  1 
ATOM   1204 C  C   . LYS A 1 174 ? -33.915 -12.349 -12.470 1.00 66.39  ? 437  LYS A C   1 
ATOM   1205 O  O   . LYS A 1 174 ? -33.518 -11.310 -13.029 1.00 61.92  ? 437  LYS A O   1 
ATOM   1206 C  CB  . LYS A 1 174 ? -35.520 -12.539 -10.505 1.00 71.22  ? 437  LYS A CB  1 
ATOM   1207 C  CG  . LYS A 1 174 ? -35.267 -11.239 -9.752  1.00 76.52  ? 437  LYS A CG  1 
ATOM   1208 C  CD  . LYS A 1 174 ? -35.103 -11.387 -8.244  1.00 78.93  ? 437  LYS A CD  1 
ATOM   1209 C  CE  . LYS A 1 174 ? -34.321 -10.228 -7.656  1.00 83.74  ? 437  LYS A CE  1 
ATOM   1210 N  NZ  . LYS A 1 174 ? -34.312 -10.252 -6.176  1.00 86.98  ? 437  LYS A NZ  1 
ATOM   1211 N  N   . GLU A 1 175 ? -33.171 -13.448 -12.275 1.00 72.33  ? 438  GLU A N   1 
ATOM   1212 C  CA  . GLU A 1 175 ? -31.734 -13.560 -12.627 1.00 62.54  ? 438  GLU A CA  1 
ATOM   1213 C  C   . GLU A 1 175 ? -31.557 -13.230 -14.109 1.00 60.17  ? 438  GLU A C   1 
ATOM   1214 O  O   . GLU A 1 175 ? -30.717 -12.328 -14.452 1.00 49.05  ? 438  GLU A O   1 
ATOM   1215 C  CB  . GLU A 1 175 ? -31.195 -14.956 -12.318 1.00 70.87  ? 438  GLU A CB  1 
ATOM   1216 C  CG  . GLU A 1 175 ? -30.256 -15.011 -11.118 1.00 78.84  ? 438  GLU A CG  1 
ATOM   1217 C  CD  . GLU A 1 175 ? -28.996 -14.158 -11.168 1.00 72.93  ? 438  GLU A CD  1 
ATOM   1218 O  OE1 . GLU A 1 175 ? -27.894 -14.714 -11.364 1.00 81.03  ? 438  GLU A OE1 1 
ATOM   1219 O  OE2 . GLU A 1 175 ? -29.108 -12.948 -10.948 1.00 84.02  ? 438  GLU A OE2 1 
ATOM   1220 N  N   . ARG A 1 176 ? -32.319 -13.930 -14.950 1.00 54.25  ? 439  ARG A N   1 
ATOM   1221 C  CA  . ARG A 1 176 ? -32.235 -13.801 -16.425 1.00 56.50  ? 439  ARG A CA  1 
ATOM   1222 C  C   . ARG A 1 176 ? -32.259 -12.323 -16.839 1.00 62.40  ? 439  ARG A C   1 
ATOM   1223 O  O   . ARG A 1 176 ? -31.438 -11.958 -17.710 1.00 61.15  ? 439  ARG A O   1 
ATOM   1224 C  CB  . ARG A 1 176 ? -33.381 -14.564 -17.078 1.00 54.85  ? 439  ARG A CB  1 
ATOM   1225 C  CG  . ARG A 1 176 ? -33.367 -14.461 -18.589 1.00 52.10  ? 439  ARG A CG  1 
ATOM   1226 C  CD  . ARG A 1 176 ? -34.036 -15.689 -19.131 1.00 54.54  ? 439  ARG A CD  1 
ATOM   1227 N  NE  . ARG A 1 176 ? -34.271 -15.520 -20.542 1.00 72.47  ? 439  ARG A NE  1 
ATOM   1228 C  CZ  . ARG A 1 176 ? -34.876 -16.420 -21.293 1.00 89.29  ? 439  ARG A CZ  1 
ATOM   1229 N  NH1 . ARG A 1 176 ? -35.289 -17.550 -20.734 1.00 88.73  ? 439  ARG A NH1 1 
ATOM   1230 N  NH2 . ARG A 1 176 ? -35.059 -16.186 -22.586 1.00 91.00  ? 439  ARG A NH2 1 
ATOM   1231 N  N   . ASN A 1 177 ? -33.145 -11.504 -16.244 1.00 67.23  ? 440  ASN A N   1 
ATOM   1232 C  CA  . ASN A 1 177 ? -33.313 -10.064 -16.605 1.00 63.60  ? 440  ASN A CA  1 
ATOM   1233 C  C   . ASN A 1 177 ? -32.102 -9.260  -16.114 1.00 67.96  ? 440  ASN A C   1 
ATOM   1234 O  O   . ASN A 1 177 ? -31.672 -8.303  -16.836 1.00 61.28  ? 440  ASN A O   1 
ATOM   1235 C  CB  . ASN A 1 177 ? -34.645 -9.507  -16.098 1.00 71.45  ? 440  ASN A CB  1 
ATOM   1236 C  CG  . ASN A 1 177 ? -35.804 -9.942  -16.974 1.00 83.60  ? 440  ASN A CG  1 
ATOM   1237 O  OD1 . ASN A 1 177 ? -35.876 -9.570  -18.150 1.00 86.51  ? 440  ASN A OD1 1 
ATOM   1238 N  ND2 . ASN A 1 177 ? -36.710 -10.737 -16.424 1.00 79.58  ? 440  ASN A ND2 1 
ATOM   1239 N  N   . LEU A 1 178 ? -31.558 -9.638  -14.949 1.00 64.49  ? 441  LEU A N   1 
ATOM   1240 C  CA  . LEU A 1 178 ? -30.264 -9.119  -14.436 1.00 61.13  ? 441  LEU A CA  1 
ATOM   1241 C  C   . LEU A 1 178 ? -29.152 -9.424  -15.448 1.00 60.32  ? 441  LEU A C   1 
ATOM   1242 O  O   . LEU A 1 178 ? -28.333 -8.509  -15.710 1.00 60.93  ? 441  LEU A O   1 
ATOM   1243 C  CB  . LEU A 1 178 ? -29.969 -9.745  -13.071 1.00 69.85  ? 441  LEU A CB  1 
ATOM   1244 C  CG  . LEU A 1 178 ? -30.852 -9.243  -11.927 1.00 77.07  ? 441  LEU A CG  1 
ATOM   1245 C  CD1 . LEU A 1 178 ? -30.632 -10.060 -10.658 1.00 80.57  ? 441  LEU A CD1 1 
ATOM   1246 C  CD2 . LEU A 1 178 ? -30.597 -7.764  -11.658 1.00 76.47  ? 441  LEU A CD2 1 
ATOM   1247 N  N   . HIS A 1 179 ? -29.131 -10.624 -16.038 1.00 58.79  ? 442  HIS A N   1 
ATOM   1248 C  CA  . HIS A 1 179 ? -28.096 -10.988 -17.048 1.00 67.11  ? 442  HIS A CA  1 
ATOM   1249 C  C   . HIS A 1 179 ? -28.200 -10.058 -18.267 1.00 65.71  ? 442  HIS A C   1 
ATOM   1250 O  O   . HIS A 1 179 ? -27.147 -9.510  -18.665 1.00 61.75  ? 442  HIS A O   1 
ATOM   1251 C  CB  . HIS A 1 179 ? -28.149 -12.477 -17.422 1.00 74.18  ? 442  HIS A CB  1 
ATOM   1252 C  CG  . HIS A 1 179 ? -27.580 -13.391 -16.386 1.00 76.46  ? 442  HIS A CG  1 
ATOM   1253 N  ND1 . HIS A 1 179 ? -27.775 -14.753 -16.429 1.00 69.94  ? 442  HIS A ND1 1 
ATOM   1254 C  CD2 . HIS A 1 179 ? -26.854 -13.139 -15.272 1.00 69.09  ? 442  HIS A CD2 1 
ATOM   1255 C  CE1 . HIS A 1 179 ? -27.189 -15.299 -15.384 1.00 77.34  ? 442  HIS A CE1 1 
ATOM   1256 N  NE2 . HIS A 1 179 ? -26.606 -14.327 -14.664 1.00 71.23  ? 442  HIS A NE2 1 
ATOM   1257 N  N   . LEU A 1 180 ? -29.416 -9.835  -18.796 1.00 68.94  ? 443  LEU A N   1 
ATOM   1258 C  CA  . LEU A 1 180 ? -29.661 -8.918  -19.955 1.00 64.84  ? 443  LEU A CA  1 
ATOM   1259 C  C   . LEU A 1 180 ? -29.219 -7.498  -19.559 1.00 65.54  ? 443  LEU A C   1 
ATOM   1260 O  O   . LEU A 1 180 ? -28.677 -6.792  -20.413 1.00 68.26  ? 443  LEU A O   1 
ATOM   1261 C  CB  . LEU A 1 180 ? -31.127 -8.993  -20.404 1.00 57.79  ? 443  LEU A CB  1 
ATOM   1262 C  CG  . LEU A 1 180 ? -31.631 -10.386 -20.811 1.00 55.37  ? 443  LEU A CG  1 
ATOM   1263 C  CD1 . LEU A 1 180 ? -33.142 -10.498 -20.658 1.00 53.77  ? 443  LEU A CD1 1 
ATOM   1264 C  CD2 . LEU A 1 180 ? -31.225 -10.765 -22.230 1.00 54.75  ? 443  LEU A CD2 1 
ATOM   1265 N  N   . GLU A 1 181 ? -29.292 -7.154  -18.275 1.00 73.94  ? 444  GLU A N   1 
ATOM   1266 C  CA  . GLU A 1 181 ? -28.800 -5.864  -17.722 1.00 84.20  ? 444  GLU A CA  1 
ATOM   1267 C  C   . GLU A 1 181 ? -27.284 -5.918  -17.434 1.00 92.74  ? 444  GLU A C   1 
ATOM   1268 O  O   . GLU A 1 181 ? -26.761 -4.915  -16.868 1.00 85.48  ? 444  GLU A O   1 
ATOM   1269 C  CB  . GLU A 1 181 ? -29.595 -5.550  -16.454 1.00 91.85  ? 444  GLU A CB  1 
ATOM   1270 C  CG  . GLU A 1 181 ? -30.038 -4.106  -16.333 1.00 101.57 ? 444  GLU A CG  1 
ATOM   1271 C  CD  . GLU A 1 181 ? -30.680 -3.792  -14.989 1.00 111.74 ? 444  GLU A CD  1 
ATOM   1272 O  OE1 . GLU A 1 181 ? -30.314 -2.753  -14.398 1.00 107.64 ? 444  GLU A OE1 1 
ATOM   1273 O  OE2 . GLU A 1 181 ? -31.537 -4.596  -14.525 1.00 105.74 ? 444  GLU A OE2 1 
ATOM   1274 N  N   . GLY A 1 182 ? -26.599 -7.023  -17.788 1.00 90.19  ? 445  GLY A N   1 
ATOM   1275 C  CA  . GLY A 1 182 ? -25.146 -7.232  -17.588 1.00 74.29  ? 445  GLY A CA  1 
ATOM   1276 C  C   . GLY A 1 182 ? -24.749 -7.273  -16.116 1.00 62.82  ? 445  GLY A C   1 
ATOM   1277 O  O   . GLY A 1 182 ? -23.664 -6.818  -15.779 1.00 63.95  ? 445  GLY A O   1 
ATOM   1278 N  N   . LYS A 1 183 ? -25.603 -7.819  -15.264 1.00 65.06  ? 446  LYS A N   1 
ATOM   1279 C  CA  . LYS A 1 183 ? -25.396 -7.936  -13.795 1.00 73.74  ? 446  LYS A CA  1 
ATOM   1280 C  C   . LYS A 1 183 ? -25.748 -9.363  -13.359 1.00 65.36  ? 446  LYS A C   1 
ATOM   1281 O  O   . LYS A 1 183 ? -26.465 -10.051 -14.105 1.00 57.56  ? 446  LYS A O   1 
ATOM   1282 C  CB  . LYS A 1 183 ? -26.282 -6.933  -13.053 1.00 79.51  ? 446  LYS A CB  1 
ATOM   1283 C  CG  . LYS A 1 183 ? -25.970 -5.476  -13.359 1.00 88.39  ? 446  LYS A CG  1 
ATOM   1284 C  CD  . LYS A 1 183 ? -26.921 -4.525  -12.690 1.00 92.98  ? 446  LYS A CD  1 
ATOM   1285 C  CE  . LYS A 1 183 ? -26.866 -3.145  -13.301 1.00 103.91 ? 446  LYS A CE  1 
ATOM   1286 N  NZ  . LYS A 1 183 ? -28.018 -2.324  -12.860 1.00 114.84 ? 446  LYS A NZ  1 
ATOM   1287 N  N   . CYS A 1 184 ? -25.283 -9.784  -12.182 1.00 70.63  ? 447  CYS A N   1 
ATOM   1288 C  CA  . CYS A 1 184 ? -25.480 -11.160 -11.647 1.00 71.82  ? 447  CYS A CA  1 
ATOM   1289 C  C   . CYS A 1 184 ? -25.671 -11.108 -10.122 1.00 70.52  ? 447  CYS A C   1 
ATOM   1290 O  O   . CYS A 1 184 ? -24.932 -10.330 -9.450  1.00 62.93  ? 447  CYS A O   1 
ATOM   1291 C  CB  . CYS A 1 184 ? -24.294 -12.048 -12.031 1.00 70.59  ? 447  CYS A CB  1 
ATOM   1292 S  SG  . CYS A 1 184 ? -24.548 -13.787 -11.592 1.00 56.60  ? 447  CYS A SG  1 
ATOM   1293 N  N   . GLU A 1 185 ? -26.586 -11.924 -9.589  1.00 68.81  ? 448  GLU A N   1 
ATOM   1294 C  CA  . GLU A 1 185 ? -26.967 -11.891 -8.147  1.00 77.93  ? 448  GLU A CA  1 
ATOM   1295 C  C   . GLU A 1 185 ? -26.685 -13.250 -7.488  1.00 71.13  ? 448  GLU A C   1 
ATOM   1296 O  O   . GLU A 1 185 ? -26.138 -13.246 -6.378  1.00 69.83  ? 448  GLU A O   1 
ATOM   1297 C  CB  . GLU A 1 185 ? -28.438 -11.472 -7.996  1.00 85.48  ? 448  GLU A CB  1 
ATOM   1298 C  CG  . GLU A 1 185 ? -28.868 -11.100 -6.575  1.00 88.91  ? 448  GLU A CG  1 
ATOM   1299 C  CD  . GLU A 1 185 ? -30.350 -10.761 -6.406  1.00 101.19 ? 448  GLU A CD  1 
ATOM   1300 O  OE1 . GLU A 1 185 ? -30.748 -9.646  -6.816  1.00 115.08 ? 448  GLU A OE1 1 
ATOM   1301 O  OE2 . GLU A 1 185 ? -31.117 -11.610 -5.868  1.00 92.65  ? 448  GLU A OE2 1 
ATOM   1302 N  N   . THR A 1 186 ? -27.061 -14.365 -8.117  1.00 66.56  ? 449  THR A N   1 
ATOM   1303 C  CA  . THR A 1 186 ? -27.109 -15.688 -7.446  1.00 73.69  ? 449  THR A CA  1 
ATOM   1304 C  C   . THR A 1 186 ? -26.199 -16.733 -8.117  1.00 72.36  ? 449  THR A C   1 
ATOM   1305 O  O   . THR A 1 186 ? -26.159 -17.858 -7.591  1.00 85.63  ? 449  THR A O   1 
ATOM   1306 C  CB  . THR A 1 186 ? -28.555 -16.185 -7.373  1.00 83.41  ? 449  THR A CB  1 
ATOM   1307 O  OG1 . THR A 1 186 ? -29.014 -16.396 -8.709  1.00 82.29  ? 449  THR A OG1 1 
ATOM   1308 C  CG2 . THR A 1 186 ? -29.460 -15.224 -6.631  1.00 87.11  ? 449  THR A CG2 1 
ATOM   1309 N  N   . CYS A 1 187 ? -25.473 -16.404 -9.190  1.00 65.15  ? 450  CYS A N   1 
ATOM   1310 C  CA  . CYS A 1 187 ? -24.624 -17.381 -9.932  1.00 60.50  ? 450  CYS A CA  1 
ATOM   1311 C  C   . CYS A 1 187 ? -23.274 -17.550 -9.220  1.00 62.25  ? 450  CYS A C   1 
ATOM   1312 O  O   . CYS A 1 187 ? -22.223 -16.978 -9.662  1.00 51.50  ? 450  CYS A O   1 
ATOM   1313 C  CB  . CYS A 1 187 ? -24.527 -17.002 -11.399 1.00 54.88  ? 450  CYS A CB  1 
ATOM   1314 S  SG  . CYS A 1 187 ? -26.184 -16.923 -12.134 1.00 59.17  ? 450  CYS A SG  1 
ATOM   1315 N  N   . VAL A 1 188 ? -23.315 -18.358 -8.159  1.00 65.61  ? 451  VAL A N   1 
ATOM   1316 C  CA  . VAL A 1 188 ? -22.167 -18.628 -7.248  1.00 72.56  ? 451  VAL A CA  1 
ATOM   1317 C  C   . VAL A 1 188 ? -21.834 -20.123 -7.282  1.00 63.91  ? 451  VAL A C   1 
ATOM   1318 O  O   . VAL A 1 188 ? -22.754 -20.953 -7.359  1.00 58.64  ? 451  VAL A O   1 
ATOM   1319 C  CB  . VAL A 1 188 ? -22.489 -18.141 -5.823  1.00 77.96  ? 451  VAL A CB  1 
ATOM   1320 C  CG1 . VAL A 1 188 ? -21.402 -18.546 -4.833  1.00 83.38  ? 451  VAL A CG1 1 
ATOM   1321 C  CG2 . VAL A 1 188 ? -22.713 -16.635 -5.809  1.00 75.51  ? 451  VAL A CG2 1 
ATOM   1322 N  N   . TYR A 1 189 ? -20.549 -20.439 -7.215  1.00 65.51  ? 452  TYR A N   1 
ATOM   1323 C  CA  . TYR A 1 189 ? -20.032 -21.830 -7.208  1.00 70.09  ? 452  TYR A CA  1 
ATOM   1324 C  C   . TYR A 1 189 ? -19.875 -22.334 -5.771  1.00 68.82  ? 452  TYR A C   1 
ATOM   1325 O  O   . TYR A 1 189 ? -19.359 -21.579 -4.920  1.00 63.79  ? 452  TYR A O   1 
ATOM   1326 C  CB  . TYR A 1 189 ? -18.708 -21.887 -7.962  1.00 66.74  ? 452  TYR A CB  1 
ATOM   1327 C  CG  . TYR A 1 189 ? -18.865 -21.727 -9.452  1.00 68.70  ? 452  TYR A CG  1 
ATOM   1328 C  CD1 . TYR A 1 189 ? -19.545 -22.673 -10.205 1.00 64.43  ? 452  TYR A CD1 1 
ATOM   1329 C  CD2 . TYR A 1 189 ? -18.359 -20.614 -10.102 1.00 69.67  ? 452  TYR A CD2 1 
ATOM   1330 C  CE1 . TYR A 1 189 ? -19.692 -22.527 -11.573 1.00 67.40  ? 452  TYR A CE1 1 
ATOM   1331 C  CE2 . TYR A 1 189 ? -18.482 -20.460 -11.473 1.00 67.16  ? 452  TYR A CE2 1 
ATOM   1332 C  CZ  . TYR A 1 189 ? -19.156 -21.418 -12.205 1.00 68.01  ? 452  TYR A CZ  1 
ATOM   1333 O  OH  . TYR A 1 189 ? -19.282 -21.254 -13.551 1.00 75.87  ? 452  TYR A OH  1 
ATOM   1334 N  N   . ASN A 1 190 ? -20.326 -23.570 -5.529  1.00 68.97  ? 453  ASN A N   1 
ATOM   1335 C  CA  . ASN A 1 190 ? -19.989 -24.388 -4.330  1.00 78.21  ? 453  ASN A CA  1 
ATOM   1336 C  C   . ASN A 1 190 ? -18.893 -25.414 -4.672  1.00 73.17  ? 453  ASN A C   1 
ATOM   1337 O  O   . ASN A 1 190 ? -19.220 -26.409 -5.308  1.00 68.00  ? 453  ASN A O   1 
ATOM   1338 C  CB  . ASN A 1 190 ? -21.256 -25.038 -3.783  1.00 82.09  ? 453  ASN A CB  1 
ATOM   1339 C  CG  . ASN A 1 190 ? -22.278 -23.985 -3.422  1.00 81.09  ? 453  ASN A CG  1 
ATOM   1340 O  OD1 . ASN A 1 190 ? -22.204 -22.861 -3.908  1.00 91.16  ? 453  ASN A OD1 1 
ATOM   1341 N  ND2 . ASN A 1 190 ? -23.203 -24.320 -2.546  1.00 82.31  ? 453  ASN A ND2 1 
ATOM   1342 N  N   . MET A 1 191 ? -17.638 -25.170 -4.272  1.00 84.13  ? 454  MET A N   1 
ATOM   1343 C  CA  . MET A 1 191 ? -16.481 -26.084 -4.520  1.00 91.91  ? 454  MET A CA  1 
ATOM   1344 C  C   . MET A 1 191 ? -16.532 -27.254 -3.524  1.00 96.89  ? 454  MET A C   1 
ATOM   1345 O  O   . MET A 1 191 ? -16.802 -26.995 -2.327  1.00 94.50  ? 454  MET A O   1 
ATOM   1346 C  CB  . MET A 1 191 ? -15.151 -25.339 -4.370  1.00 89.55  ? 454  MET A CB  1 
ATOM   1347 C  CG  . MET A 1 191 ? -13.951 -26.148 -4.823  1.00 101.05 ? 454  MET A CG  1 
ATOM   1348 S  SD  . MET A 1 191 ? -12.432 -25.163 -4.986  1.00 111.88 ? 454  MET A SD  1 
ATOM   1349 C  CE  . MET A 1 191 ? -12.615 -24.556 -6.661  1.00 113.81 ? 454  MET A CE  1 
ATOM   1350 N  N   . MET A 1 192 ? -16.300 -28.487 -4.004  1.00 104.39 ? 455  MET A N   1 
ATOM   1351 C  CA  . MET A 1 192 ? -16.314 -29.748 -3.198  1.00 110.59 ? 455  MET A CA  1 
ATOM   1352 C  C   . MET A 1 192 ? -15.332 -30.775 -3.793  1.00 112.56 ? 455  MET A C   1 
ATOM   1353 O  O   . MET A 1 192 ? -15.676 -31.400 -4.828  1.00 105.80 ? 455  MET A O   1 
ATOM   1354 C  CB  . MET A 1 192 ? -17.724 -30.351 -3.148  1.00 111.52 ? 455  MET A CB  1 
ATOM   1355 C  CG  . MET A 1 192 ? -18.554 -29.871 -1.973  1.00 106.94 ? 455  MET A CG  1 
ATOM   1356 S  SD  . MET A 1 192 ? -20.337 -29.876 -2.307  1.00 112.30 ? 455  MET A SD  1 
ATOM   1357 C  CE  . MET A 1 192 ? -20.658 -31.608 -2.645  1.00 103.04 ? 455  MET A CE  1 
ATOM   1358 N  N   . SER A 1 208 ? -6.880  -35.472 -8.938  1.00 149.80 ? 471  SER A N   1 
ATOM   1359 C  CA  . SER A 1 208 ? -6.995  -34.250 -9.781  1.00 149.22 ? 471  SER A CA  1 
ATOM   1360 C  C   . SER A 1 208 ? -8.469  -33.981 -10.125 1.00 146.32 ? 471  SER A C   1 
ATOM   1361 O  O   . SER A 1 208 ? -8.788  -33.907 -11.330 1.00 148.44 ? 471  SER A O   1 
ATOM   1362 C  CB  . SER A 1 208 ? -6.136  -34.356 -11.036 1.00 139.46 ? 471  SER A CB  1 
ATOM   1363 O  OG  . SER A 1 208 ? -4.829  -33.839 -10.824 1.00 124.15 ? 471  SER A OG  1 
ATOM   1364 N  N   . ARG A 1 209 ? -9.339  -33.844 -9.115  1.00 137.93 ? 472  ARG A N   1 
ATOM   1365 C  CA  . ARG A 1 209 ? -10.768 -33.466 -9.305  1.00 150.43 ? 472  ARG A CA  1 
ATOM   1366 C  C   . ARG A 1 209 ? -11.227 -32.522 -8.186  1.00 145.43 ? 472  ARG A C   1 
ATOM   1367 O  O   . ARG A 1 209 ? -10.689 -32.606 -7.066  1.00 147.44 ? 472  ARG A O   1 
ATOM   1368 C  CB  . ARG A 1 209 ? -11.691 -34.690 -9.324  1.00 158.39 ? 472  ARG A CB  1 
ATOM   1369 C  CG  . ARG A 1 209 ? -11.389 -35.721 -10.404 1.00 164.22 ? 472  ARG A CG  1 
ATOM   1370 C  CD  . ARG A 1 209 ? -12.405 -36.853 -10.424 1.00 164.34 ? 472  ARG A CD  1 
ATOM   1371 N  NE  . ARG A 1 209 ? -13.003 -37.092 -9.112  1.00 170.64 ? 472  ARG A NE  1 
ATOM   1372 C  CZ  . ARG A 1 209 ? -12.436 -37.765 -8.111  1.00 167.92 ? 472  ARG A CZ  1 
ATOM   1373 N  NH1 . ARG A 1 209 ? -13.082 -37.904 -6.965  1.00 162.97 ? 472  ARG A NH1 1 
ATOM   1374 N  NH2 . ARG A 1 209 ? -11.230 -38.295 -8.246  1.00 168.82 ? 472  ARG A NH2 1 
ATOM   1375 N  N   . ALA A 1 210 ? -12.173 -31.642 -8.524  1.00 140.01 ? 473  ALA A N   1 
ATOM   1376 C  CA  . ALA A 1 210 ? -13.100 -30.920 -7.620  1.00 132.88 ? 473  ALA A CA  1 
ATOM   1377 C  C   . ALA A 1 210 ? -14.276 -30.443 -8.487  1.00 123.74 ? 473  ALA A C   1 
ATOM   1378 O  O   . ALA A 1 210 ? -14.008 -29.972 -9.611  1.00 112.52 ? 473  ALA A O   1 
ATOM   1379 C  CB  . ALA A 1 210 ? -12.391 -29.785 -6.913  1.00 122.44 ? 473  ALA A CB  1 
ATOM   1380 N  N   . ILE A 1 211 ? -15.523 -30.630 -8.040  1.00 118.62 ? 474  ILE A N   1 
ATOM   1381 C  CA  . ILE A 1 211 ? -16.736 -30.352 -8.871  1.00 115.10 ? 474  ILE A CA  1 
ATOM   1382 C  C   . ILE A 1 211 ? -17.406 -29.085 -8.340  1.00 110.61 ? 474  ILE A C   1 
ATOM   1383 O  O   . ILE A 1 211 ? -17.666 -29.027 -7.124  1.00 121.28 ? 474  ILE A O   1 
ATOM   1384 C  CB  . ILE A 1 211 ? -17.713 -31.541 -8.899  1.00 116.65 ? 474  ILE A CB  1 
ATOM   1385 C  CG1 . ILE A 1 211 ? -16.983 -32.867 -9.136  1.00 125.18 ? 474  ILE A CG1 1 
ATOM   1386 C  CG2 . ILE A 1 211 ? -18.812 -31.302 -9.929  1.00 111.87 ? 474  ILE A CG2 1 
ATOM   1387 C  CD1 . ILE A 1 211 ? -16.471 -33.542 -7.877  1.00 133.42 ? 474  ILE A CD1 1 
ATOM   1388 N  N   . TRP A 1 212 ? -17.655 -28.121 -9.229  1.00 94.91  ? 475  TRP A N   1 
ATOM   1389 C  CA  . TRP A 1 212 ? -18.158 -26.765 -8.895  1.00 89.86  ? 475  TRP A CA  1 
ATOM   1390 C  C   . TRP A 1 212 ? -19.675 -26.778 -9.065  1.00 87.57  ? 475  TRP A C   1 
ATOM   1391 O  O   . TRP A 1 212 ? -20.152 -26.358 -10.141 1.00 94.17  ? 475  TRP A O   1 
ATOM   1392 C  CB  . TRP A 1 212 ? -17.484 -25.697 -9.770  1.00 94.14  ? 475  TRP A CB  1 
ATOM   1393 C  CG  . TRP A 1 212 ? -15.988 -25.666 -9.681  1.00 95.09  ? 475  TRP A CG  1 
ATOM   1394 C  CD1 . TRP A 1 212 ? -15.153 -26.721 -9.457  1.00 102.56 ? 475  TRP A CD1 1 
ATOM   1395 C  CD2 . TRP A 1 212 ? -15.131 -24.523 -9.850  1.00 91.04  ? 475  TRP A CD2 1 
ATOM   1396 N  NE1 . TRP A 1 212 ? -13.848 -26.312 -9.452  1.00 98.99  ? 475  TRP A NE1 1 
ATOM   1397 C  CE2 . TRP A 1 212 ? -13.800 -24.970 -9.693  1.00 84.59  ? 475  TRP A CE2 1 
ATOM   1398 C  CE3 . TRP A 1 212 ? -15.353 -23.168 -10.104 1.00 85.93  ? 475  TRP A CE3 1 
ATOM   1399 C  CZ2 . TRP A 1 212 ? -12.701 -24.124 -9.797  1.00 82.15  ? 475  TRP A CZ2 1 
ATOM   1400 C  CZ3 . TRP A 1 212 ? -14.264 -22.329 -10.208 1.00 91.67  ? 475  TRP A CZ3 1 
ATOM   1401 C  CH2 . TRP A 1 212 ? -12.957 -22.800 -10.055 1.00 87.06  ? 475  TRP A CH2 1 
ATOM   1402 N  N   . TYR A 1 213 ? -20.393 -27.278 -8.052  1.00 78.83  ? 476  TYR A N   1 
ATOM   1403 C  CA  . TYR A 1 213 ? -21.878 -27.300 -8.000  1.00 79.42  ? 476  TYR A CA  1 
ATOM   1404 C  C   . TYR A 1 213 ? -22.401 -25.858 -8.039  1.00 68.73  ? 476  TYR A C   1 
ATOM   1405 O  O   . TYR A 1 213 ? -21.734 -24.929 -7.549  1.00 60.22  ? 476  TYR A O   1 
ATOM   1406 C  CB  . TYR A 1 213 ? -22.402 -28.046 -6.767  1.00 82.09  ? 476  TYR A CB  1 
ATOM   1407 C  CG  . TYR A 1 213 ? -22.094 -29.524 -6.719  1.00 92.91  ? 476  TYR A CG  1 
ATOM   1408 C  CD1 . TYR A 1 213 ? -22.941 -30.456 -7.296  1.00 99.57  ? 476  TYR A CD1 1 
ATOM   1409 C  CD2 . TYR A 1 213 ? -20.967 -30.005 -6.072  1.00 96.67  ? 476  TYR A CD2 1 
ATOM   1410 C  CE1 . TYR A 1 213 ? -22.674 -31.816 -7.252  1.00 105.19 ? 476  TYR A CE1 1 
ATOM   1411 C  CE2 . TYR A 1 213 ? -20.682 -31.361 -6.015  1.00 100.56 ? 476  TYR A CE2 1 
ATOM   1412 C  CZ  . TYR A 1 213 ? -21.538 -32.272 -6.606  1.00 106.70 ? 476  TYR A CZ  1 
ATOM   1413 O  OH  . TYR A 1 213 ? -21.264 -33.609 -6.549  1.00 113.31 ? 476  TYR A OH  1 
ATOM   1414 N  N   . MET A 1 214 ? -23.563 -25.671 -8.654  1.00 68.57  ? 477  MET A N   1 
ATOM   1415 C  CA  . MET A 1 214 ? -24.304 -24.388 -8.646  1.00 72.84  ? 477  MET A CA  1 
ATOM   1416 C  C   . MET A 1 214 ? -25.759 -24.694 -8.322  1.00 65.23  ? 477  MET A C   1 
ATOM   1417 O  O   . MET A 1 214 ? -26.131 -25.859 -8.450  1.00 72.90  ? 477  MET A O   1 
ATOM   1418 C  CB  . MET A 1 214 ? -24.240 -23.702 -10.010 1.00 78.76  ? 477  MET A CB  1 
ATOM   1419 C  CG  . MET A 1 214 ? -22.951 -22.981 -10.265 1.00 78.68  ? 477  MET A CG  1 
ATOM   1420 S  SD  . MET A 1 214 ? -23.050 -22.108 -11.836 1.00 84.84  ? 477  MET A SD  1 
ATOM   1421 C  CE  . MET A 1 214 ? -22.466 -20.486 -11.342 1.00 74.60  ? 477  MET A CE  1 
ATOM   1422 N  N   . TRP A 1 215 ? -26.554 -23.688 -7.966  1.00 63.30  ? 478  TRP A N   1 
ATOM   1423 C  CA  . TRP A 1 215 ? -28.014 -23.880 -7.755  1.00 64.41  ? 478  TRP A CA  1 
ATOM   1424 C  C   . TRP A 1 215 ? -28.701 -24.060 -9.117  1.00 61.39  ? 478  TRP A C   1 
ATOM   1425 O  O   . TRP A 1 215 ? -28.187 -23.554 -10.119 1.00 60.26  ? 478  TRP A O   1 
ATOM   1426 C  CB  . TRP A 1 215 ? -28.603 -22.765 -6.880  1.00 65.13  ? 478  TRP A CB  1 
ATOM   1427 C  CG  . TRP A 1 215 ? -29.172 -21.574 -7.583  1.00 62.27  ? 478  TRP A CG  1 
ATOM   1428 C  CD1 . TRP A 1 215 ? -28.504 -20.459 -8.006  1.00 69.07  ? 478  TRP A CD1 1 
ATOM   1429 C  CD2 . TRP A 1 215 ? -30.564 -21.334 -7.846  1.00 62.79  ? 478  TRP A CD2 1 
ATOM   1430 N  NE1 . TRP A 1 215 ? -29.381 -19.561 -8.561  1.00 73.02  ? 478  TRP A NE1 1 
ATOM   1431 C  CE2 . TRP A 1 215 ? -30.653 -20.068 -8.472  1.00 69.00  ? 478  TRP A CE2 1 
ATOM   1432 C  CE3 . TRP A 1 215 ? -31.731 -22.073 -7.628  1.00 64.83  ? 478  TRP A CE3 1 
ATOM   1433 C  CZ2 . TRP A 1 215 ? -31.865 -19.532 -8.906  1.00 67.17  ? 478  TRP A CZ2 1 
ATOM   1434 C  CZ3 . TRP A 1 215 ? -32.927 -21.542 -8.061  1.00 66.26  ? 478  TRP A CZ3 1 
ATOM   1435 C  CH2 . TRP A 1 215 ? -32.989 -20.292 -8.685  1.00 65.31  ? 478  TRP A CH2 1 
ATOM   1436 N  N   . LEU A 1 216 ? -29.768 -24.851 -9.149  1.00 63.46  ? 479  LEU A N   1 
ATOM   1437 C  CA  . LEU A 1 216 ? -30.344 -25.409 -10.394 1.00 69.60  ? 479  LEU A CA  1 
ATOM   1438 C  C   . LEU A 1 216 ? -30.595 -24.269 -11.388 1.00 70.49  ? 479  LEU A C   1 
ATOM   1439 O  O   . LEU A 1 216 ? -30.286 -24.452 -12.565 1.00 70.96  ? 479  LEU A O   1 
ATOM   1440 C  CB  . LEU A 1 216 ? -31.634 -26.153 -10.057 1.00 65.32  ? 479  LEU A CB  1 
ATOM   1441 C  CG  . LEU A 1 216 ? -32.101 -27.125 -11.128 1.00 65.49  ? 479  LEU A CG  1 
ATOM   1442 C  CD1 . LEU A 1 216 ? -31.118 -28.272 -11.270 1.00 69.93  ? 479  LEU A CD1 1 
ATOM   1443 C  CD2 . LEU A 1 216 ? -33.491 -27.639 -10.808 1.00 69.75  ? 479  LEU A CD2 1 
ATOM   1444 N  N   . GLY A 1 217 ? -31.098 -23.130 -10.910 1.00 66.18  ? 480  GLY A N   1 
ATOM   1445 C  CA  . GLY A 1 217 ? -31.379 -21.942 -11.737 1.00 66.25  ? 480  GLY A CA  1 
ATOM   1446 C  C   . GLY A 1 217 ? -30.146 -21.408 -12.454 1.00 61.38  ? 480  GLY A C   1 
ATOM   1447 O  O   . GLY A 1 217 ? -30.265 -21.034 -13.627 1.00 58.46  ? 480  GLY A O   1 
ATOM   1448 N  N   . ALA A 1 218 ? -29.006 -21.328 -11.767 1.00 64.46  ? 481  ALA A N   1 
ATOM   1449 C  CA  . ALA A 1 218 ? -27.700 -20.928 -12.353 1.00 62.68  ? 481  ALA A CA  1 
ATOM   1450 C  C   . ALA A 1 218 ? -27.330 -21.890 -13.502 1.00 59.36  ? 481  ALA A C   1 
ATOM   1451 O  O   . ALA A 1 218 ? -26.899 -21.388 -14.562 1.00 53.03  ? 481  ALA A O   1 
ATOM   1452 C  CB  . ALA A 1 218 ? -26.666 -20.880 -11.269 1.00 55.21  ? 481  ALA A CB  1 
ATOM   1453 N  N   . ARG A 1 219 ? -27.583 -23.193 -13.319 1.00 55.50  ? 482  ARG A N   1 
ATOM   1454 C  CA  . ARG A 1 219 ? -27.357 -24.282 -14.306 1.00 57.88  ? 482  ARG A CA  1 
ATOM   1455 C  C   . ARG A 1 219 ? -28.323 -24.163 -15.470 1.00 55.06  ? 482  ARG A C   1 
ATOM   1456 O  O   . ARG A 1 219 ? -27.888 -24.454 -16.586 1.00 54.62  ? 482  ARG A O   1 
ATOM   1457 C  CB  . ARG A 1 219 ? -27.571 -25.687 -13.733 1.00 64.45  ? 482  ARG A CB  1 
ATOM   1458 C  CG  . ARG A 1 219 ? -26.288 -26.506 -13.641 1.00 80.06  ? 482  ARG A CG  1 
ATOM   1459 C  CD  . ARG A 1 219 ? -25.377 -25.911 -12.580 1.00 86.64  ? 482  ARG A CD  1 
ATOM   1460 N  NE  . ARG A 1 219 ? -23.997 -26.383 -12.522 1.00 81.26  ? 482  ARG A NE  1 
ATOM   1461 C  CZ  . ARG A 1 219 ? -22.947 -25.777 -13.072 1.00 84.75  ? 482  ARG A CZ  1 
ATOM   1462 N  NH1 . ARG A 1 219 ? -23.081 -24.683 -13.804 1.00 88.72  ? 482  ARG A NH1 1 
ATOM   1463 N  NH2 . ARG A 1 219 ? -21.742 -26.284 -12.892 1.00 99.14  ? 482  ARG A NH2 1 
ATOM   1464 N  N   . PHE A 1 220 ? -29.587 -23.811 -15.225 1.00 53.90  ? 483  PHE A N   1 
ATOM   1465 C  CA  . PHE A 1 220 ? -30.565 -23.579 -16.311 1.00 49.04  ? 483  PHE A CA  1 
ATOM   1466 C  C   . PHE A 1 220 ? -30.002 -22.529 -17.272 1.00 45.93  ? 483  PHE A C   1 
ATOM   1467 O  O   . PHE A 1 220 ? -30.001 -22.742 -18.499 1.00 51.06  ? 483  PHE A O   1 
ATOM   1468 C  CB  . PHE A 1 220 ? -31.932 -23.091 -15.824 1.00 54.99  ? 483  PHE A CB  1 
ATOM   1469 C  CG  . PHE A 1 220 ? -32.797 -22.713 -16.997 1.00 46.43  ? 483  PHE A CG  1 
ATOM   1470 C  CD1 . PHE A 1 220 ? -33.346 -23.697 -17.800 1.00 51.43  ? 483  PHE A CD1 1 
ATOM   1471 C  CD2 . PHE A 1 220 ? -32.889 -21.394 -17.406 1.00 47.67  ? 483  PHE A CD2 1 
ATOM   1472 C  CE1 . PHE A 1 220 ? -34.066 -23.364 -18.935 1.00 55.96  ? 483  PHE A CE1 1 
ATOM   1473 C  CE2 . PHE A 1 220 ? -33.615 -21.053 -18.538 1.00 48.47  ? 483  PHE A CE2 1 
ATOM   1474 C  CZ  . PHE A 1 220 ? -34.215 -22.038 -19.286 1.00 53.73  ? 483  PHE A CZ  1 
ATOM   1475 N  N   . LEU A 1 221 ? -29.535 -21.414 -16.726 1.00 48.95  ? 484  LEU A N   1 
ATOM   1476 C  CA  . LEU A 1 221 ? -29.141 -20.234 -17.538 1.00 55.05  ? 484  LEU A CA  1 
ATOM   1477 C  C   . LEU A 1 221 ? -27.869 -20.550 -18.325 1.00 54.00  ? 484  LEU A C   1 
ATOM   1478 O  O   . LEU A 1 221 ? -27.763 -20.101 -19.503 1.00 51.03  ? 484  LEU A O   1 
ATOM   1479 C  CB  . LEU A 1 221 ? -28.973 -19.023 -16.615 1.00 61.84  ? 484  LEU A CB  1 
ATOM   1480 C  CG  . LEU A 1 221 ? -30.288 -18.430 -16.085 1.00 64.23  ? 484  LEU A CG  1 
ATOM   1481 C  CD1 . LEU A 1 221 ? -30.032 -17.420 -14.972 1.00 62.44  ? 484  LEU A CD1 1 
ATOM   1482 C  CD2 . LEU A 1 221 ? -31.092 -17.780 -17.195 1.00 63.37  ? 484  LEU A CD2 1 
ATOM   1483 N  N   . GLU A 1 222 ? -26.942 -21.302 -17.722 1.00 46.91  ? 485  GLU A N   1 
ATOM   1484 C  CA  . GLU A 1 222 ? -25.763 -21.809 -18.460 1.00 48.45  ? 485  GLU A CA  1 
ATOM   1485 C  C   . GLU A 1 222 ? -26.257 -22.704 -19.615 1.00 44.58  ? 485  GLU A C   1 
ATOM   1486 O  O   . GLU A 1 222 ? -25.773 -22.531 -20.746 1.00 43.23  ? 485  GLU A O   1 
ATOM   1487 C  CB  . GLU A 1 222 ? -24.791 -22.489 -17.487 1.00 47.69  ? 485  GLU A CB  1 
ATOM   1488 C  CG  . GLU A 1 222 ? -23.659 -23.221 -18.182 1.00 52.65  ? 485  GLU A CG  1 
ATOM   1489 C  CD  . GLU A 1 222 ? -22.728 -23.951 -17.231 1.00 54.74  ? 485  GLU A CD  1 
ATOM   1490 O  OE1 . GLU A 1 222 ? -21.606 -23.458 -17.009 1.00 56.48  ? 485  GLU A OE1 1 
ATOM   1491 O  OE2 . GLU A 1 222 ? -23.127 -25.007 -16.738 1.00 56.36  ? 485  GLU A OE2 1 
ATOM   1492 N  N   . PHE A 1 223 ? -27.157 -23.647 -19.337 1.00 46.17  ? 486  PHE A N   1 
ATOM   1493 C  CA  . PHE A 1 223 ? -27.712 -24.621 -20.314 1.00 52.04  ? 486  PHE A CA  1 
ATOM   1494 C  C   . PHE A 1 223 ? -28.449 -23.903 -21.454 1.00 52.48  ? 486  PHE A C   1 
ATOM   1495 O  O   . PHE A 1 223 ? -28.323 -24.294 -22.633 1.00 50.04  ? 486  PHE A O   1 
ATOM   1496 C  CB  . PHE A 1 223 ? -28.639 -25.617 -19.614 1.00 49.17  ? 486  PHE A CB  1 
ATOM   1497 C  CG  . PHE A 1 223 ? -29.384 -26.521 -20.560 1.00 52.27  ? 486  PHE A CG  1 
ATOM   1498 C  CD1 . PHE A 1 223 ? -28.731 -27.548 -21.214 1.00 47.36  ? 486  PHE A CD1 1 
ATOM   1499 C  CD2 . PHE A 1 223 ? -30.737 -26.319 -20.818 1.00 54.16  ? 486  PHE A CD2 1 
ATOM   1500 C  CE1 . PHE A 1 223 ? -29.415 -28.367 -22.101 1.00 51.30  ? 486  PHE A CE1 1 
ATOM   1501 C  CE2 . PHE A 1 223 ? -31.421 -27.141 -21.702 1.00 50.34  ? 486  PHE A CE2 1 
ATOM   1502 C  CZ  . PHE A 1 223 ? -30.754 -28.160 -22.345 1.00 54.42  ? 486  PHE A CZ  1 
ATOM   1503 N  N   . GLU A 1 224 ? -29.215 -22.870 -21.103 0.50 51.96  ? 487  GLU A N   1 
ATOM   1504 C  CA  . GLU A 1 224 ? -29.999 -22.039 -22.054 0.50 54.16  ? 487  GLU A CA  1 
ATOM   1505 C  C   . GLU A 1 224 ? -29.055 -21.377 -23.068 0.50 52.31  ? 487  GLU A C   1 
ATOM   1506 O  O   . GLU A 1 224 ? -29.376 -21.380 -24.276 0.50 50.93  ? 487  GLU A O   1 
ATOM   1507 C  CB  . GLU A 1 224 ? -30.798 -20.995 -21.275 0.50 57.70  ? 487  GLU A CB  1 
ATOM   1508 C  CG  . GLU A 1 224 ? -31.448 -19.939 -22.150 0.50 59.04  ? 487  GLU A CG  1 
ATOM   1509 C  CD  . GLU A 1 224 ? -32.416 -19.039 -21.402 0.50 59.16  ? 487  GLU A CD  1 
ATOM   1510 O  OE1 . GLU A 1 224 ? -33.631 -19.310 -21.472 0.50 60.11  ? 487  GLU A OE1 1 
ATOM   1511 O  OE2 . GLU A 1 224 ? -31.952 -18.081 -20.743 0.50 55.07  ? 487  GLU A OE2 1 
ATOM   1512 N  N   . ALA A 1 225 ? -27.912 -20.873 -22.593 0.50 48.92  ? 488  ALA A N   1 
ATOM   1513 C  CA  . ALA A 1 225 ? -26.975 -20.019 -23.359 0.50 46.38  ? 488  ALA A CA  1 
ATOM   1514 C  C   . ALA A 1 225 ? -25.962 -20.856 -24.150 0.50 46.00  ? 488  ALA A C   1 
ATOM   1515 O  O   . ALA A 1 225 ? -25.575 -20.391 -25.249 0.50 44.51  ? 488  ALA A O   1 
ATOM   1516 C  CB  . ALA A 1 225 ? -26.272 -19.074 -22.422 0.50 45.92  ? 488  ALA A CB  1 
ATOM   1517 N  N   . LEU A 1 226 ? -25.498 -21.987 -23.595 1.00 45.04  ? 489  LEU A N   1 
ATOM   1518 C  CA  . LEU A 1 226 ? -24.375 -22.779 -24.196 1.00 40.90  ? 489  LEU A CA  1 
ATOM   1519 C  C   . LEU A 1 226 ? -24.689 -24.264 -24.409 1.00 38.29  ? 489  LEU A C   1 
ATOM   1520 O  O   . LEU A 1 226 ? -23.799 -24.952 -24.993 1.00 38.28  ? 489  LEU A O   1 
ATOM   1521 C  CB  . LEU A 1 226 ? -23.146 -22.600 -23.304 1.00 37.75  ? 489  LEU A CB  1 
ATOM   1522 C  CG  . LEU A 1 226 ? -22.655 -21.158 -23.170 1.00 41.84  ? 489  LEU A CG  1 
ATOM   1523 C  CD1 . LEU A 1 226 ? -21.518 -21.042 -22.144 1.00 40.09  ? 489  LEU A CD1 1 
ATOM   1524 C  CD2 . LEU A 1 226 ? -22.218 -20.625 -24.526 1.00 41.42  ? 489  LEU A CD2 1 
ATOM   1525 N  N   . GLY A 1 227 ? -25.861 -24.743 -23.973 1.00 34.68  ? 490  GLY A N   1 
ATOM   1526 C  CA  . GLY A 1 227 ? -26.321 -26.136 -24.126 1.00 34.74  ? 490  GLY A CA  1 
ATOM   1527 C  C   . GLY A 1 227 ? -26.294 -26.607 -25.572 1.00 35.56  ? 490  GLY A C   1 
ATOM   1528 O  O   . GLY A 1 227 ? -26.107 -27.823 -25.821 1.00 38.36  ? 490  GLY A O   1 
ATOM   1529 N  N   . PHE A 1 228 ? -26.483 -25.702 -26.529 1.00 36.69  ? 491  PHE A N   1 
ATOM   1530 C  CA  . PHE A 1 228 ? -26.509 -26.071 -27.970 1.00 36.59  ? 491  PHE A CA  1 
ATOM   1531 C  C   . PHE A 1 228 ? -25.209 -26.809 -28.360 1.00 32.75  ? 491  PHE A C   1 
ATOM   1532 O  O   . PHE A 1 228 ? -25.285 -27.679 -29.203 1.00 36.82  ? 491  PHE A O   1 
ATOM   1533 C  CB  . PHE A 1 228 ? -26.770 -24.845 -28.853 1.00 35.13  ? 491  PHE A CB  1 
ATOM   1534 C  CG  . PHE A 1 228 ? -25.626 -23.879 -28.952 1.00 32.75  ? 491  PHE A CG  1 
ATOM   1535 C  CD1 . PHE A 1 228 ? -25.448 -22.885 -28.008 1.00 36.15  ? 491  PHE A CD1 1 
ATOM   1536 C  CD2 . PHE A 1 228 ? -24.702 -23.974 -29.976 1.00 37.89  ? 491  PHE A CD2 1 
ATOM   1537 C  CE1 . PHE A 1 228 ? -24.393 -21.990 -28.091 1.00 34.08  ? 491  PHE A CE1 1 
ATOM   1538 C  CE2 . PHE A 1 228 ? -23.606 -23.121 -30.028 1.00 33.87  ? 491  PHE A CE2 1 
ATOM   1539 C  CZ  . PHE A 1 228 ? -23.439 -22.143 -29.077 1.00 35.56  ? 491  PHE A CZ  1 
ATOM   1540 N  N   . LEU A 1 229 ? -24.061 -26.478 -27.769 1.00 35.99  ? 492  LEU A N   1 
ATOM   1541 C  CA  . LEU A 1 229 ? -22.735 -27.079 -28.114 1.00 37.27  ? 492  LEU A CA  1 
ATOM   1542 C  C   . LEU A 1 229 ? -22.817 -28.606 -28.012 1.00 34.33  ? 492  LEU A C   1 
ATOM   1543 O  O   . LEU A 1 229 ? -22.387 -29.304 -28.944 1.00 34.20  ? 492  LEU A O   1 
ATOM   1544 C  CB  . LEU A 1 229 ? -21.699 -26.481 -27.162 1.00 40.00  ? 492  LEU A CB  1 
ATOM   1545 C  CG  . LEU A 1 229 ? -21.301 -25.028 -27.428 1.00 39.71  ? 492  LEU A CG  1 
ATOM   1546 C  CD1 . LEU A 1 229 ? -20.354 -24.546 -26.358 1.00 38.83  ? 492  LEU A CD1 1 
ATOM   1547 C  CD2 . LEU A 1 229 ? -20.662 -24.878 -28.803 1.00 41.14  ? 492  LEU A CD2 1 
ATOM   1548 N  N   . ASN A 1 230 ? -23.456 -29.099 -26.956 1.00 38.33  ? 493  ASN A N   1 
ATOM   1549 C  CA  . ASN A 1 230 ? -23.685 -30.547 -26.690 1.00 40.69  ? 493  ASN A CA  1 
ATOM   1550 C  C   . ASN A 1 230 ? -24.997 -31.024 -27.332 1.00 39.67  ? 493  ASN A C   1 
ATOM   1551 O  O   . ASN A 1 230 ? -24.989 -32.104 -27.983 1.00 43.33  ? 493  ASN A O   1 
ATOM   1552 C  CB  . ASN A 1 230 ? -23.702 -30.835 -25.174 1.00 43.86  ? 493  ASN A CB  1 
ATOM   1553 C  CG  . ASN A 1 230 ? -23.809 -32.320 -24.878 1.00 53.11  ? 493  ASN A CG  1 
ATOM   1554 O  OD1 . ASN A 1 230 ? -24.816 -32.800 -24.338 1.00 50.02  ? 493  ASN A OD1 1 
ATOM   1555 N  ND2 . ASN A 1 230 ? -22.774 -33.065 -25.250 1.00 52.84  ? 493  ASN A ND2 1 
ATOM   1556 N  N   . GLU A 1 231 ? -26.109 -30.313 -27.095 1.00 41.86  ? 494  GLU A N   1 
ATOM   1557 C  CA  . GLU A 1 231 ? -27.463 -30.721 -27.586 1.00 38.55  ? 494  GLU A CA  1 
ATOM   1558 C  C   . GLU A 1 231 ? -27.436 -30.898 -29.117 1.00 38.53  ? 494  GLU A C   1 
ATOM   1559 O  O   . GLU A 1 231 ? -28.057 -31.870 -29.582 1.00 35.77  ? 494  GLU A O   1 
ATOM   1560 C  CB  . GLU A 1 231 ? -28.544 -29.725 -27.159 1.00 41.41  ? 494  GLU A CB  1 
ATOM   1561 C  CG  . GLU A 1 231 ? -28.989 -29.851 -25.703 1.00 46.58  ? 494  GLU A CG  1 
ATOM   1562 C  CD  . GLU A 1 231 ? -29.267 -31.260 -25.201 1.00 54.98  ? 494  GLU A CD  1 
ATOM   1563 O  OE1 . GLU A 1 231 ? -30.151 -31.946 -25.792 1.00 57.38  ? 494  GLU A OE1 1 
ATOM   1564 O  OE2 . GLU A 1 231 ? -28.557 -31.691 -24.252 1.00 64.53  ? 494  GLU A OE2 1 
ATOM   1565 N  N   . ASP A 1 232 ? -26.695 -30.071 -29.870 1.00 33.87  ? 495  ASP A N   1 
ATOM   1566 C  CA  . ASP A 1 232 ? -26.654 -30.177 -31.353 1.00 35.13  ? 495  ASP A CA  1 
ATOM   1567 C  C   . ASP A 1 232 ? -25.299 -30.718 -31.849 1.00 38.64  ? 495  ASP A C   1 
ATOM   1568 O  O   . ASP A 1 232 ? -25.024 -30.579 -33.029 1.00 38.03  ? 495  ASP A O   1 
ATOM   1569 C  CB  . ASP A 1 232 ? -27.016 -28.816 -31.945 1.00 40.61  ? 495  ASP A CB  1 
ATOM   1570 C  CG  . ASP A 1 232 ? -28.373 -28.350 -31.437 1.00 40.94  ? 495  ASP A CG  1 
ATOM   1571 O  OD1 . ASP A 1 232 ? -29.168 -29.235 -31.072 1.00 41.18  ? 495  ASP A OD1 1 
ATOM   1572 O  OD2 . ASP A 1 232 ? -28.598 -27.132 -31.356 1.00 39.22  ? 495  ASP A OD2 1 
ATOM   1573 N  N   . HIS A 1 233 ? -24.467 -31.320 -30.999 1.00 40.65  ? 496  HIS A N   1 
ATOM   1574 C  CA  . HIS A 1 233 ? -23.336 -32.163 -31.448 1.00 38.87  ? 496  HIS A CA  1 
ATOM   1575 C  C   . HIS A 1 233 ? -22.305 -31.339 -32.227 1.00 33.22  ? 496  HIS A C   1 
ATOM   1576 O  O   . HIS A 1 233 ? -21.932 -31.750 -33.294 1.00 34.80  ? 496  HIS A O   1 
ATOM   1577 C  CB  . HIS A 1 233 ? -23.911 -33.285 -32.301 1.00 44.15  ? 496  HIS A CB  1 
ATOM   1578 C  CG  . HIS A 1 233 ? -24.993 -34.026 -31.608 1.00 51.89  ? 496  HIS A CG  1 
ATOM   1579 N  ND1 . HIS A 1 233 ? -24.818 -34.596 -30.368 1.00 60.64  ? 496  HIS A ND1 1 
ATOM   1580 C  CD2 . HIS A 1 233 ? -26.270 -34.280 -31.960 1.00 57.81  ? 496  HIS A CD2 1 
ATOM   1581 C  CE1 . HIS A 1 233 ? -25.930 -35.202 -29.999 1.00 55.77  ? 496  HIS A CE1 1 
ATOM   1582 N  NE2 . HIS A 1 233 ? -26.829 -35.021 -30.957 1.00 50.32  ? 496  HIS A NE2 1 
ATOM   1583 N  N   . TRP A 1 234 ? -21.911 -30.190 -31.701 1.00 29.94  ? 497  TRP A N   1 
ATOM   1584 C  CA  . TRP A 1 234 ? -20.930 -29.314 -32.387 1.00 33.47  ? 497  TRP A CA  1 
ATOM   1585 C  C   . TRP A 1 234 ? -19.567 -30.010 -32.429 1.00 38.01  ? 497  TRP A C   1 
ATOM   1586 O  O   . TRP A 1 234 ? -18.789 -29.716 -33.340 1.00 35.64  ? 497  TRP A O   1 
ATOM   1587 C  CB  . TRP A 1 234 ? -20.866 -27.954 -31.686 1.00 33.13  ? 497  TRP A CB  1 
ATOM   1588 C  CG  . TRP A 1 234 ? -21.924 -26.995 -32.130 1.00 39.34  ? 497  TRP A CG  1 
ATOM   1589 C  CD1 . TRP A 1 234 ? -23.271 -27.202 -32.136 1.00 40.85  ? 497  TRP A CD1 1 
ATOM   1590 C  CD2 . TRP A 1 234 ? -21.720 -25.666 -32.640 1.00 41.99  ? 497  TRP A CD2 1 
ATOM   1591 N  NE1 . TRP A 1 234 ? -23.917 -26.098 -32.618 1.00 44.74  ? 497  TRP A NE1 1 
ATOM   1592 C  CE2 . TRP A 1 234 ? -22.993 -25.139 -32.935 1.00 44.22  ? 497  TRP A CE2 1 
ATOM   1593 C  CE3 . TRP A 1 234 ? -20.591 -24.876 -32.878 1.00 44.48  ? 497  TRP A CE3 1 
ATOM   1594 C  CZ2 . TRP A 1 234 ? -23.165 -23.857 -33.451 1.00 42.66  ? 497  TRP A CZ2 1 
ATOM   1595 C  CZ3 . TRP A 1 234 ? -20.762 -23.611 -33.391 1.00 46.56  ? 497  TRP A CZ3 1 
ATOM   1596 C  CH2 . TRP A 1 234 ? -22.032 -23.110 -33.672 1.00 44.66  ? 497  TRP A CH2 1 
ATOM   1597 N  N   . PHE A 1 235 ? -19.328 -30.934 -31.500 1.00 36.22  ? 498  PHE A N   1 
ATOM   1598 C  CA  . PHE A 1 235 ? -18.017 -31.624 -31.410 1.00 34.19  ? 498  PHE A CA  1 
ATOM   1599 C  C   . PHE A 1 235 ? -18.137 -33.063 -31.926 1.00 34.82  ? 498  PHE A C   1 
ATOM   1600 O  O   . PHE A 1 235 ? -17.326 -33.900 -31.520 1.00 40.16  ? 498  PHE A O   1 
ATOM   1601 C  CB  . PHE A 1 235 ? -17.459 -31.423 -30.001 1.00 33.40  ? 498  PHE A CB  1 
ATOM   1602 C  CG  . PHE A 1 235 ? -17.107 -29.986 -29.723 1.00 32.39  ? 498  PHE A CG  1 
ATOM   1603 C  CD1 . PHE A 1 235 ? -15.997 -29.406 -30.311 1.00 34.33  ? 498  PHE A CD1 1 
ATOM   1604 C  CD2 . PHE A 1 235 ? -17.906 -29.203 -28.908 1.00 35.33  ? 498  PHE A CD2 1 
ATOM   1605 C  CE1 . PHE A 1 235 ? -15.679 -28.079 -30.072 1.00 38.18  ? 498  PHE A CE1 1 
ATOM   1606 C  CE2 . PHE A 1 235 ? -17.587 -27.877 -28.670 1.00 36.90  ? 498  PHE A CE2 1 
ATOM   1607 C  CZ  . PHE A 1 235 ? -16.475 -27.318 -29.252 1.00 35.04  ? 498  PHE A CZ  1 
ATOM   1608 N  N   . SER A 1 236 ? -19.108 -33.326 -32.800 0.50 32.90  ? 499  SER A N   1 
ATOM   1609 C  CA  . SER A 1 236 ? -19.188 -34.651 -33.461 0.50 33.69  ? 499  SER A CA  1 
ATOM   1610 C  C   . SER A 1 236 ? -17.988 -34.756 -34.407 0.50 33.63  ? 499  SER A C   1 
ATOM   1611 O  O   . SER A 1 236 ? -17.482 -33.707 -34.820 0.50 33.66  ? 499  SER A O   1 
ATOM   1612 C  CB  . SER A 1 236 ? -20.473 -34.799 -34.225 0.50 33.59  ? 499  SER A CB  1 
ATOM   1613 O  OG  . SER A 1 236 ? -20.476 -33.963 -35.370 0.50 30.82  ? 499  SER A OG  1 
ATOM   1614 N  N   . ARG A 1 237 ? -17.572 -35.972 -34.756 0.50 33.77  ? 500  ARG A N   1 
ATOM   1615 C  CA  . ARG A 1 237 ? -16.447 -36.131 -35.713 0.50 34.75  ? 500  ARG A CA  1 
ATOM   1616 C  C   . ARG A 1 237 ? -16.856 -35.544 -37.068 0.50 35.93  ? 500  ARG A C   1 
ATOM   1617 O  O   . ARG A 1 237 ? -16.012 -34.909 -37.708 0.50 35.14  ? 500  ARG A O   1 
ATOM   1618 C  CB  . ARG A 1 237 ? -16.013 -37.595 -35.824 0.50 34.65  ? 500  ARG A CB  1 
ATOM   1619 C  CG  . ARG A 1 237 ? -14.661 -37.775 -36.498 0.50 33.95  ? 500  ARG A CG  1 
ATOM   1620 C  CD  . ARG A 1 237 ? -13.899 -38.973 -35.974 0.50 33.20  ? 500  ARG A CD  1 
ATOM   1621 N  NE  . ARG A 1 237 ? -12.511 -38.926 -36.403 0.50 32.60  ? 500  ARG A NE  1 
ATOM   1622 C  CZ  . ARG A 1 237 ? -11.548 -38.288 -35.752 0.50 31.91  ? 500  ARG A CZ  1 
ATOM   1623 N  NH1 . ARG A 1 237 ? -11.824 -37.640 -34.633 0.50 31.57  ? 500  ARG A NH1 1 
ATOM   1624 N  NH2 . ARG A 1 237 ? -10.315 -38.298 -36.221 0.50 30.75  ? 500  ARG A NH2 1 
ATOM   1625 N  N   . GLU A 1 238 ? -18.113 -35.739 -37.465 0.50 38.05  ? 501  GLU A N   1 
ATOM   1626 C  CA  . GLU A 1 238 ? -18.598 -35.235 -38.777 0.50 38.55  ? 501  GLU A CA  1 
ATOM   1627 C  C   . GLU A 1 238 ? -18.472 -33.710 -38.826 0.50 36.26  ? 501  GLU A C   1 
ATOM   1628 O  O   . GLU A 1 238 ? -18.052 -33.195 -39.869 0.50 36.63  ? 501  GLU A O   1 
ATOM   1629 C  CB  . GLU A 1 238 ? -20.042 -35.681 -39.011 0.50 41.26  ? 501  GLU A CB  1 
ATOM   1630 C  CG  . GLU A 1 238 ? -20.519 -35.463 -40.435 0.50 44.38  ? 501  GLU A CG  1 
ATOM   1631 C  CD  . GLU A 1 238 ? -21.831 -36.148 -40.775 0.50 47.94  ? 501  GLU A CD  1 
ATOM   1632 O  OE1 . GLU A 1 238 ? -22.079 -36.381 -41.974 0.50 50.46  ? 501  GLU A OE1 1 
ATOM   1633 O  OE2 . GLU A 1 238 ? -22.602 -36.445 -39.843 0.50 52.42  ? 501  GLU A OE2 1 
ATOM   1634 N  N   . ASN A 1 239 ? -18.804 -33.023 -37.733 0.50 34.70  ? 502  ASN A N   1 
ATOM   1635 C  CA  . ASN A 1 239 ? -18.792 -31.537 -37.732 0.50 34.63  ? 502  ASN A CA  1 
ATOM   1636 C  C   . ASN A 1 239 ? -17.429 -30.976 -37.309 0.50 34.28  ? 502  ASN A C   1 
ATOM   1637 O  O   . ASN A 1 239 ? -17.066 -29.917 -37.839 0.50 33.64  ? 502  ASN A O   1 
ATOM   1638 C  CB  . ASN A 1 239 ? -19.883 -30.974 -36.818 0.50 34.36  ? 502  ASN A CB  1 
ATOM   1639 C  CG  . ASN A 1 239 ? -20.070 -29.479 -36.954 0.50 35.08  ? 502  ASN A CG  1 
ATOM   1640 O  OD1 . ASN A 1 239 ? -20.522 -28.999 -37.990 0.50 35.08  ? 502  ASN A OD1 1 
ATOM   1641 N  ND2 . ASN A 1 239 ? -19.740 -28.737 -35.911 0.50 34.94  ? 502  ASN A ND2 1 
ATOM   1642 N  N   . SER A 1 240 ? -16.711 -31.642 -36.399 0.50 32.83  ? 503  SER A N   1 
ATOM   1643 C  CA  . SER A 1 240 ? -15.449 -31.076 -35.844 0.50 32.73  ? 503  SER A CA  1 
ATOM   1644 C  C   . SER A 1 240 ? -14.203 -31.752 -36.428 0.50 32.61  ? 503  SER A C   1 
ATOM   1645 O  O   . SER A 1 240 ? -13.124 -31.157 -36.298 0.50 32.75  ? 503  SER A O   1 
ATOM   1646 C  CB  . SER A 1 240 ? -15.453 -31.168 -34.341 0.50 33.22  ? 503  SER A CB  1 
ATOM   1647 O  OG  . SER A 1 240 ? -15.458 -32.519 -33.913 0.50 33.56  ? 503  SER A OG  1 
ATOM   1648 N  N   . LEU A 1 241 ? -14.344 -32.953 -36.995 0.50 32.99  ? 504  LEU A N   1 
ATOM   1649 C  CA  . LEU A 1 241 ? -13.212 -33.689 -37.630 0.50 34.26  ? 504  LEU A CA  1 
ATOM   1650 C  C   . LEU A 1 241 ? -12.270 -34.275 -36.567 0.50 34.23  ? 504  LEU A C   1 
ATOM   1651 O  O   . LEU A 1 241 ? -11.818 -35.409 -36.759 0.50 32.85  ? 504  LEU A O   1 
ATOM   1652 C  CB  . LEU A 1 241 ? -12.474 -32.752 -38.592 0.50 35.25  ? 504  LEU A CB  1 
ATOM   1653 C  CG  . LEU A 1 241 ? -13.320 -32.175 -39.725 0.50 36.20  ? 504  LEU A CG  1 
ATOM   1654 C  CD1 . LEU A 1 241 ? -12.454 -31.392 -40.697 0.50 36.88  ? 504  LEU A CD1 1 
ATOM   1655 C  CD2 . LEU A 1 241 ? -14.066 -33.279 -40.455 0.50 35.34  ? 504  LEU A CD2 1 
ATOM   1656 N  N   . SER A 1 242 ? -11.996 -33.529 -35.496 0.50 33.21  ? 505  SER A N   1 
ATOM   1657 C  CA  . SER A 1 242 ? -11.111 -34.011 -34.405 0.50 33.59  ? 505  SER A CA  1 
ATOM   1658 C  C   . SER A 1 242 ? -11.946 -34.589 -33.260 0.50 31.79  ? 505  SER A C   1 
ATOM   1659 O  O   . SER A 1 242 ? -11.427 -35.454 -32.545 0.50 29.93  ? 505  SER A O   1 
ATOM   1660 C  CB  . SER A 1 242 ? -10.224 -32.895 -33.908 0.50 33.96  ? 505  SER A CB  1 
ATOM   1661 O  OG  . SER A 1 242 ? -9.498  -32.299 -34.966 0.50 34.75  ? 505  SER A OG  1 
ATOM   1662 N  N   . GLY A 1 243 ? -13.187 -34.123 -33.097 1.00 32.36  ? 506  GLY A N   1 
ATOM   1663 C  CA  . GLY A 1 243 ? -14.023 -34.553 -31.953 1.00 31.71  ? 506  GLY A CA  1 
ATOM   1664 C  C   . GLY A 1 243 ? -14.547 -35.973 -32.064 1.00 32.15  ? 506  GLY A C   1 
ATOM   1665 O  O   . GLY A 1 243 ? -14.460 -36.569 -33.155 1.00 30.79  ? 506  GLY A O   1 
ATOM   1666 N  N   . VAL A 1 244 ? -15.069 -36.469 -30.937 1.00 29.51  ? 507  VAL A N   1 
ATOM   1667 C  CA  . VAL A 1 244 ? -15.582 -37.859 -30.827 1.00 32.79  ? 507  VAL A CA  1 
ATOM   1668 C  C   . VAL A 1 244 ? -16.869 -37.858 -29.979 1.00 35.79  ? 507  VAL A C   1 
ATOM   1669 O  O   . VAL A 1 244 ? -17.246 -38.920 -29.479 1.00 34.82  ? 507  VAL A O   1 
ATOM   1670 C  CB  . VAL A 1 244 ? -14.501 -38.745 -30.184 1.00 32.70  ? 507  VAL A CB  1 
ATOM   1671 C  CG1 . VAL A 1 244 ? -13.266 -38.871 -31.059 1.00 32.63  ? 507  VAL A CG1 1 
ATOM   1672 C  CG2 . VAL A 1 244 ? -14.128 -38.262 -28.792 1.00 33.23  ? 507  VAL A CG2 1 
ATOM   1673 N  N   . GLU A 1 245 ? -17.506 -36.700 -29.811 1.00 36.81  ? 508  GLU A N   1 
ATOM   1674 C  CA  . GLU A 1 245 ? -18.726 -36.593 -28.966 1.00 39.20  ? 508  GLU A CA  1 
ATOM   1675 C  C   . GLU A 1 245 ? -19.862 -37.423 -29.570 1.00 35.18  ? 508  GLU A C   1 
ATOM   1676 O  O   . GLU A 1 245 ? -20.143 -37.258 -30.760 1.00 34.57  ? 508  GLU A O   1 
ATOM   1677 C  CB  . GLU A 1 245 ? -19.140 -35.134 -28.783 1.00 41.93  ? 508  GLU A CB  1 
ATOM   1678 C  CG  . GLU A 1 245 ? -20.236 -34.935 -27.752 1.00 45.76  ? 508  GLU A CG  1 
ATOM   1679 C  CD  . GLU A 1 245 ? -21.649 -35.173 -28.255 1.00 49.88  ? 508  GLU A CD  1 
ATOM   1680 O  OE1 . GLU A 1 245 ? -21.934 -34.799 -29.404 1.00 49.67  ? 508  GLU A OE1 1 
ATOM   1681 O  OE2 . GLU A 1 245 ? -22.457 -35.737 -27.498 1.00 55.76  ? 508  GLU A OE2 1 
ATOM   1682 N  N   . GLY A 1 246 ? -20.466 -38.289 -28.759 1.00 36.77  ? 509  GLY A N   1 
ATOM   1683 C  CA  . GLY A 1 246 ? -21.573 -39.141 -29.227 1.00 39.68  ? 509  GLY A CA  1 
ATOM   1684 C  C   . GLY A 1 246 ? -21.130 -40.237 -30.174 1.00 38.90  ? 509  GLY A C   1 
ATOM   1685 O  O   . GLY A 1 246 ? -21.999 -40.844 -30.801 1.00 41.56  ? 509  GLY A O   1 
ATOM   1686 N  N   . GLU A 1 247 ? -19.828 -40.494 -30.263 1.00 35.95  ? 510  GLU A N   1 
ATOM   1687 C  CA  . GLU A 1 247 ? -19.344 -41.602 -31.126 1.00 41.50  ? 510  GLU A CA  1 
ATOM   1688 C  C   . GLU A 1 247 ? -19.604 -42.953 -30.440 1.00 38.68  ? 510  GLU A C   1 
ATOM   1689 O  O   . GLU A 1 247 ? -20.139 -43.838 -31.104 1.00 42.94  ? 510  GLU A O   1 
ATOM   1690 C  CB  . GLU A 1 247 ? -17.887 -41.380 -31.539 1.00 36.62  ? 510  GLU A CB  1 
ATOM   1691 C  CG  . GLU A 1 247 ? -17.678 -40.110 -32.340 1.00 41.44  ? 510  GLU A CG  1 
ATOM   1692 C  CD  . GLU A 1 247 ? -18.488 -40.015 -33.620 1.00 46.60  ? 510  GLU A CD  1 
ATOM   1693 O  OE1 . GLU A 1 247 ? -18.609 -41.036 -34.312 1.00 46.04  ? 510  GLU A OE1 1 
ATOM   1694 O  OE2 . GLU A 1 247 ? -19.001 -38.919 -33.913 1.00 43.60  ? 510  GLU A OE2 1 
ATOM   1695 N  N   . GLY A 1 248 ? -19.257 -43.094 -29.164 1.00 36.33  ? 511  GLY A N   1 
ATOM   1696 C  CA  . GLY A 1 248 ? -19.416 -44.387 -28.473 1.00 38.86  ? 511  GLY A CA  1 
ATOM   1697 C  C   . GLY A 1 248 ? -18.127 -45.190 -28.416 1.00 39.25  ? 511  GLY A C   1 
ATOM   1698 O  O   . GLY A 1 248 ? -17.359 -45.090 -29.379 1.00 40.00  ? 511  GLY A O   1 
ATOM   1699 N  N   A LEU A 1 249 ? -17.997 -45.975 -27.464 0.20 38.18  ? 512  LEU A N   1 
ATOM   1700 N  N   B LEU A 1 249 ? -17.953 -45.933 -27.434 0.20 39.05  ? 512  LEU A N   1 
ATOM   1701 C  CA  A LEU A 1 249 ? -16.724 -46.670 -27.151 0.20 37.18  ? 512  LEU A CA  1 
ATOM   1702 C  CA  B LEU A 1 249 ? -16.683 -46.671 -27.192 0.20 38.44  ? 512  LEU A CA  1 
ATOM   1703 C  C   A LEU A 1 249 ? -16.451 -47.770 -28.185 0.20 37.66  ? 512  LEU A C   1 
ATOM   1704 C  C   B LEU A 1 249 ? -16.412 -47.639 -28.345 0.20 38.33  ? 512  LEU A C   1 
ATOM   1705 O  O   A LEU A 1 249 ? -15.297 -48.216 -28.265 0.20 36.04  ? 512  LEU A O   1 
ATOM   1706 O  O   B LEU A 1 249 ? -15.237 -47.867 -28.650 0.20 36.10  ? 512  LEU A O   1 
ATOM   1707 C  CB  A LEU A 1 249 ? -16.846 -47.246 -25.743 0.20 36.38  ? 512  LEU A CB  1 
ATOM   1708 C  CB  B LEU A 1 249 ? -16.781 -47.436 -25.874 0.20 38.49  ? 512  LEU A CB  1 
ATOM   1709 C  CG  A LEU A 1 249 ? -15.561 -47.813 -25.159 0.20 34.57  ? 512  LEU A CG  1 
ATOM   1710 C  CG  B LEU A 1 249 ? -15.932 -46.879 -24.739 0.20 37.71  ? 512  LEU A CG  1 
ATOM   1711 C  CD1 A LEU A 1 249 ? -14.527 -46.714 -24.973 0.20 35.72  ? 512  LEU A CD1 1 
ATOM   1712 C  CD1 B LEU A 1 249 ? -16.058 -47.750 -23.501 0.20 37.22  ? 512  LEU A CD1 1 
ATOM   1713 C  CD2 A LEU A 1 249 ? -15.849 -48.517 -23.845 0.20 34.40  ? 512  LEU A CD2 1 
ATOM   1714 C  CD2 B LEU A 1 249 ? -14.481 -46.756 -25.173 0.20 38.41  ? 512  LEU A CD2 1 
ATOM   1715 N  N   . HIS A 1 250 ? -17.474 -48.178 -28.943 0.40 36.52  ? 513  HIS A N   1 
ATOM   1716 C  CA  . HIS A 1 250 ? -17.388 -49.186 -30.033 0.40 37.59  ? 513  HIS A CA  1 
ATOM   1717 C  C   . HIS A 1 250 ? -16.798 -48.559 -31.308 0.40 37.46  ? 513  HIS A C   1 
ATOM   1718 O  O   . HIS A 1 250 ? -16.427 -49.326 -32.220 0.40 37.76  ? 513  HIS A O   1 
ATOM   1719 C  CB  . HIS A 1 250 ? -18.773 -49.807 -30.280 0.40 38.71  ? 513  HIS A CB  1 
ATOM   1720 C  CG  . HIS A 1 250 ? -19.830 -48.793 -30.557 0.40 37.85  ? 513  HIS A CG  1 
ATOM   1721 N  ND1 . HIS A 1 250 ? -20.347 -47.982 -29.565 0.40 38.88  ? 513  HIS A ND1 1 
ATOM   1722 C  CD2 . HIS A 1 250 ? -20.444 -48.434 -31.703 0.40 38.52  ? 513  HIS A CD2 1 
ATOM   1723 C  CE1 . HIS A 1 250 ? -21.243 -47.172 -30.090 0.40 38.50  ? 513  HIS A CE1 1 
ATOM   1724 N  NE2 . HIS A 1 250 ? -21.318 -47.427 -31.400 0.40 38.91  ? 513  HIS A NE2 1 
ATOM   1725 N  N   . LYS A 1 251 ? -16.709 -47.226 -31.378 0.40 37.35  ? 514  LYS A N   1 
ATOM   1726 C  CA  . LYS A 1 251 ? -16.249 -46.499 -32.595 0.40 38.22  ? 514  LYS A CA  1 
ATOM   1727 C  C   . LYS A 1 251 ? -14.857 -45.891 -32.381 0.40 37.30  ? 514  LYS A C   1 
ATOM   1728 O  O   . LYS A 1 251 ? -14.146 -45.718 -33.388 0.40 37.30  ? 514  LYS A O   1 
ATOM   1729 C  CB  . LYS A 1 251 ? -17.256 -45.411 -32.974 0.40 40.21  ? 514  LYS A CB  1 
ATOM   1730 C  CG  . LYS A 1 251 ? -18.707 -45.862 -32.912 0.40 42.96  ? 514  LYS A CG  1 
ATOM   1731 C  CD  . LYS A 1 251 ? -19.446 -45.772 -34.216 0.40 45.48  ? 514  LYS A CD  1 
ATOM   1732 C  CE  . LYS A 1 251 ? -19.928 -44.368 -34.506 0.40 46.31  ? 514  LYS A CE  1 
ATOM   1733 N  NZ  . LYS A 1 251 ? -21.093 -44.378 -35.420 0.40 46.61  ? 514  LYS A NZ  1 
ATOM   1734 N  N   . LEU A 1 252 ? -14.497 -45.552 -31.138 1.00 35.07  ? 515  LEU A N   1 
ATOM   1735 C  CA  . LEU A 1 252 ? -13.222 -44.860 -30.827 1.00 34.20  ? 515  LEU A CA  1 
ATOM   1736 C  C   . LEU A 1 252 ? -12.055 -45.653 -31.410 1.00 32.09  ? 515  LEU A C   1 
ATOM   1737 O  O   . LEU A 1 252 ? -11.205 -45.036 -32.053 1.00 31.33  ? 515  LEU A O   1 
ATOM   1738 C  CB  . LEU A 1 252 ? -13.071 -44.706 -29.311 1.00 32.66  ? 515  LEU A CB  1 
ATOM   1739 C  CG  . LEU A 1 252 ? -14.115 -43.849 -28.631 1.00 32.21  ? 515  LEU A CG  1 
ATOM   1740 C  CD1 . LEU A 1 252 ? -13.695 -43.561 -27.220 1.00 34.40  ? 515  LEU A CD1 1 
ATOM   1741 C  CD2 . LEU A 1 252 ? -14.373 -42.555 -29.389 1.00 32.88  ? 515  LEU A CD2 1 
ATOM   1742 N  N   . GLY A 1 253 ? -12.048 -46.979 -31.247 1.00 32.14  ? 516  GLY A N   1 
ATOM   1743 C  CA  . GLY A 1 253 ? -10.973 -47.841 -31.780 1.00 34.36  ? 516  GLY A CA  1 
ATOM   1744 C  C   . GLY A 1 253 ? -10.881 -47.766 -33.298 1.00 33.63  ? 516  GLY A C   1 
ATOM   1745 O  O   . GLY A 1 253 ? -9.748  -47.663 -33.820 1.00 33.62  ? 516  GLY A O   1 
ATOM   1746 N  N   . TYR A 1 254 ? -12.022 -47.816 -33.993 1.00 30.05  ? 517  TYR A N   1 
ATOM   1747 C  CA  . TYR A 1 254 ? -12.053 -47.679 -35.468 1.00 32.61  ? 517  TYR A CA  1 
ATOM   1748 C  C   . TYR A 1 254 ? -11.545 -46.297 -35.850 1.00 32.90  ? 517  TYR A C   1 
ATOM   1749 O  O   . TYR A 1 254 ? -10.801 -46.207 -36.861 1.00 34.12  ? 517  TYR A O   1 
ATOM   1750 C  CB  . TYR A 1 254 ? -13.431 -47.894 -36.080 1.00 31.91  ? 517  TYR A CB  1 
ATOM   1751 C  CG  . TYR A 1 254 ? -13.915 -49.316 -36.081 1.00 30.62  ? 517  TYR A CG  1 
ATOM   1752 C  CD1 . TYR A 1 254 ? -13.384 -50.251 -36.966 1.00 31.86  ? 517  TYR A CD1 1 
ATOM   1753 C  CD2 . TYR A 1 254 ? -14.882 -49.739 -35.173 1.00 32.28  ? 517  TYR A CD2 1 
ATOM   1754 C  CE1 . TYR A 1 254 ? -13.831 -51.566 -36.991 1.00 29.80  ? 517  TYR A CE1 1 
ATOM   1755 C  CE2 . TYR A 1 254 ? -15.328 -51.056 -35.171 1.00 30.93  ? 517  TYR A CE2 1 
ATOM   1756 C  CZ  . TYR A 1 254 ? -14.809 -51.967 -36.089 1.00 33.57  ? 517  TYR A CZ  1 
ATOM   1757 O  OH  . TYR A 1 254 ? -15.286 -53.252 -36.142 1.00 39.33  ? 517  TYR A OH  1 
ATOM   1758 N  N   . ILE A 1 255 ? -11.867 -45.287 -35.048 1.00 28.94  ? 518  ILE A N   1 
ATOM   1759 C  CA  . ILE A 1 255 ? -11.437 -43.895 -35.323 1.00 32.97  ? 518  ILE A CA  1 
ATOM   1760 C  C   . ILE A 1 255 ? -9.912  -43.788 -35.175 1.00 35.35  ? 518  ILE A C   1 
ATOM   1761 O  O   . ILE A 1 255 ? -9.294  -43.237 -36.097 1.00 35.39  ? 518  ILE A O   1 
ATOM   1762 C  CB  . ILE A 1 255 ? -12.214 -42.893 -34.440 1.00 33.73  ? 518  ILE A CB  1 
ATOM   1763 C  CG1 . ILE A 1 255 ? -13.673 -42.778 -34.915 1.00 31.40  ? 518  ILE A CG1 1 
ATOM   1764 C  CG2 . ILE A 1 255 ? -11.510 -41.524 -34.374 1.00 29.80  ? 518  ILE A CG2 1 
ATOM   1765 C  CD1 . ILE A 1 255 ? -14.585 -42.074 -33.932 1.00 33.42  ? 518  ILE A CD1 1 
ATOM   1766 N  N   . LEU A 1 256 ? -9.328  -44.289 -34.078 1.00 36.40  ? 519  LEU A N   1 
ATOM   1767 C  CA  . LEU A 1 256 ? -7.855  -44.309 -33.893 1.00 37.17  ? 519  LEU A CA  1 
ATOM   1768 C  C   . LEU A 1 256 ? -7.186  -45.074 -35.037 1.00 35.84  ? 519  LEU A C   1 
ATOM   1769 O  O   . LEU A 1 256 ? -6.092  -44.626 -35.499 1.00 36.60  ? 519  LEU A O   1 
ATOM   1770 C  CB  . LEU A 1 256 ? -7.459  -44.945 -32.563 1.00 36.98  ? 519  LEU A CB  1 
ATOM   1771 C  CG  . LEU A 1 256 ? -7.850  -44.175 -31.306 1.00 38.56  ? 519  LEU A CG  1 
ATOM   1772 C  CD1 . LEU A 1 256 ? -7.120  -44.783 -30.123 1.00 40.71  ? 519  LEU A CD1 1 
ATOM   1773 C  CD2 . LEU A 1 256 ? -7.534  -42.689 -31.416 1.00 37.46  ? 519  LEU A CD2 1 
ATOM   1774 N  N   . ARG A 1 257 ? -7.766  -46.196 -35.461 1.00 35.82  ? 520  ARG A N   1 
ATOM   1775 C  CA  . ARG A 1 257 ? -7.205  -46.963 -36.603 1.00 36.11  ? 520  ARG A CA  1 
ATOM   1776 C  C   . ARG A 1 257 ? -7.269  -46.128 -37.885 1.00 35.37  ? 520  ARG A C   1 
ATOM   1777 O  O   . ARG A 1 257 ? -6.337  -46.281 -38.686 1.00 36.91  ? 520  ARG A O   1 
ATOM   1778 C  CB  . ARG A 1 257 ? -7.886  -48.308 -36.823 1.00 37.49  ? 520  ARG A CB  1 
ATOM   1779 C  CG  . ARG A 1 257 ? -7.241  -49.146 -37.928 1.00 39.12  ? 520  ARG A CG  1 
ATOM   1780 C  CD  . ARG A 1 257 ? -7.883  -50.508 -38.055 1.00 37.47  ? 520  ARG A CD  1 
ATOM   1781 N  NE  . ARG A 1 257 ? -9.199  -50.406 -38.695 1.00 40.15  ? 520  ARG A NE  1 
ATOM   1782 C  CZ  . ARG A 1 257 ? -9.973  -51.442 -39.014 1.00 38.36  ? 520  ARG A CZ  1 
ATOM   1783 N  NH1 . ARG A 1 257 ? -9.611  -52.683 -38.733 1.00 42.97  ? 520  ARG A NH1 1 
ATOM   1784 N  NH2 . ARG A 1 257 ? -11.108 -51.231 -39.629 1.00 37.46  ? 520  ARG A NH2 1 
ATOM   1785 N  N   . ASP A 1 258 ? -8.301  -45.301 -38.095 1.00 37.27  ? 521  ASP A N   1 
ATOM   1786 C  CA  . ASP A 1 258 ? -8.381  -44.451 -39.332 1.00 41.79  ? 521  ASP A CA  1 
ATOM   1787 C  C   . ASP A 1 258 ? -7.327  -43.329 -39.270 1.00 37.98  ? 521  ASP A C   1 
ATOM   1788 O  O   . ASP A 1 258 ? -6.759  -43.013 -40.303 1.00 45.25  ? 521  ASP A O   1 
ATOM   1789 C  CB  . ASP A 1 258 ? -9.768  -43.863 -39.620 1.00 43.48  ? 521  ASP A CB  1 
ATOM   1790 C  CG  . ASP A 1 258 ? -10.795 -44.783 -40.298 1.00 42.39  ? 521  ASP A CG  1 
ATOM   1791 O  OD1 . ASP A 1 258 ? -10.414 -45.831 -40.836 1.00 41.13  ? 521  ASP A OD1 1 
ATOM   1792 O  OD2 . ASP A 1 258 ? -11.998 -44.448 -40.242 1.00 42.69  ? 521  ASP A OD2 1 
ATOM   1793 N  N   . VAL A 1 259 ? -7.050  -42.754 -38.105 1.00 35.12  ? 522  VAL A N   1 
ATOM   1794 C  CA  . VAL A 1 259 ? -5.916  -41.806 -37.921 1.00 35.50  ? 522  VAL A CA  1 
ATOM   1795 C  C   . VAL A 1 259 ? -4.616  -42.529 -38.291 1.00 39.33  ? 522  VAL A C   1 
ATOM   1796 O  O   . VAL A 1 259 ? -3.827  -41.959 -39.009 1.00 40.68  ? 522  VAL A O   1 
ATOM   1797 C  CB  . VAL A 1 259 ? -5.861  -41.273 -36.487 1.00 37.36  ? 522  VAL A CB  1 
ATOM   1798 C  CG1 . VAL A 1 259 ? -4.606  -40.448 -36.255 1.00 41.41  ? 522  VAL A CG1 1 
ATOM   1799 C  CG2 . VAL A 1 259 ? -7.112  -40.454 -36.168 1.00 39.85  ? 522  VAL A CG2 1 
ATOM   1800 N  N   . SER A 1 260 ? -4.416  -43.763 -37.840 1.00 38.71  ? 523  SER A N   1 
ATOM   1801 C  CA  . SER A 1 260 ? -3.173  -44.532 -38.106 1.00 43.20  ? 523  SER A CA  1 
ATOM   1802 C  C   . SER A 1 260 ? -2.954  -44.667 -39.624 1.00 43.31  ? 523  SER A C   1 
ATOM   1803 O  O   . SER A 1 260 ? -1.844  -44.779 -40.023 1.00 40.18  ? 523  SER A O   1 
ATOM   1804 C  CB  . SER A 1 260 ? -3.203  -45.883 -37.441 1.00 40.67  ? 523  SER A CB  1 
ATOM   1805 O  OG  . SER A 1 260 ? -3.881  -46.817 -38.276 1.00 42.44  ? 523  SER A OG  1 
ATOM   1806 N  N   . LYS A 1 261 ? -3.990  -44.644 -40.450 1.00 45.63  ? 524  LYS A N   1 
ATOM   1807 C  CA  . LYS A 1 261 ? -3.869  -44.961 -41.900 1.00 47.58  ? 524  LYS A CA  1 
ATOM   1808 C  C   . LYS A 1 261 ? -3.209  -43.802 -42.652 1.00 44.15  ? 524  LYS A C   1 
ATOM   1809 O  O   . LYS A 1 261 ? -2.745  -44.027 -43.771 1.00 48.94  ? 524  LYS A O   1 
ATOM   1810 C  CB  . LYS A 1 261 ? -5.235  -45.319 -42.480 1.00 48.84  ? 524  LYS A CB  1 
ATOM   1811 C  CG  . LYS A 1 261 ? -5.514  -46.813 -42.421 1.00 60.93  ? 524  LYS A CG  1 
ATOM   1812 C  CD  . LYS A 1 261 ? -6.975  -47.230 -42.626 1.00 63.38  ? 524  LYS A CD  1 
ATOM   1813 C  CE  . LYS A 1 261 ? -7.227  -48.558 -41.938 1.00 68.41  ? 524  LYS A CE  1 
ATOM   1814 N  NZ  . LYS A 1 261 ? -8.215  -49.400 -42.649 1.00 81.95  ? 524  LYS A NZ  1 
ATOM   1815 N  N   . LYS A 1 262 ? -3.200  -42.622 -42.049 1.00 45.45  ? 525  LYS A N   1 
ATOM   1816 C  CA  . LYS A 1 262 ? -2.636  -41.378 -42.615 1.00 46.62  ? 525  LYS A CA  1 
ATOM   1817 C  C   . LYS A 1 262 ? -1.134  -41.517 -42.647 1.00 50.35  ? 525  LYS A C   1 
ATOM   1818 O  O   . LYS A 1 262 ? -0.611  -42.224 -41.799 1.00 54.89  ? 525  LYS A O   1 
ATOM   1819 C  CB  . LYS A 1 262 ? -3.013  -40.175 -41.751 1.00 47.54  ? 525  LYS A CB  1 
ATOM   1820 C  CG  . LYS A 1 262 ? -4.519  -39.955 -41.692 1.00 50.01  ? 525  LYS A CG  1 
ATOM   1821 C  CD  . LYS A 1 262 ? -4.900  -38.525 -41.646 1.00 55.91  ? 525  LYS A CD  1 
ATOM   1822 C  CE  . LYS A 1 262 ? -6.360  -38.264 -41.923 1.00 61.48  ? 525  LYS A CE  1 
ATOM   1823 N  NZ  . LYS A 1 262 ? -6.477  -37.131 -42.874 1.00 67.76  ? 525  LYS A NZ  1 
ATOM   1824 N  N   . GLU A 1 263 ? -0.494  -40.849 -43.595 1.00 51.80  ? 526  GLU A N   1 
ATOM   1825 C  CA  . GLU A 1 263 ? 0.978   -40.795 -43.662 1.00 49.24  ? 526  GLU A CA  1 
ATOM   1826 C  C   . GLU A 1 263 ? 1.390   -39.859 -42.546 1.00 45.77  ? 526  GLU A C   1 
ATOM   1827 O  O   . GLU A 1 263 ? 0.723   -38.818 -42.409 1.00 47.64  ? 526  GLU A O   1 
ATOM   1828 C  CB  . GLU A 1 263 ? 1.451   -40.294 -45.028 1.00 60.33  ? 526  GLU A CB  1 
ATOM   1829 C  CG  . GLU A 1 263 ? 1.001   -41.184 -46.193 1.00 73.53  ? 526  GLU A CG  1 
ATOM   1830 C  CD  . GLU A 1 263 ? 1.416   -42.651 -46.096 1.00 76.37  ? 526  GLU A CD  1 
ATOM   1831 O  OE1 . GLU A 1 263 ? 2.621   -42.914 -45.901 1.00 77.96  ? 526  GLU A OE1 1 
ATOM   1832 O  OE2 . GLU A 1 263 ? 0.533   -43.533 -46.206 1.00 77.98  ? 526  GLU A OE2 1 
ATOM   1833 N  N   . GLY A 1 264 ? 2.408   -40.229 -41.772 1.00 43.40  ? 527  GLY A N   1 
ATOM   1834 C  CA  . GLY A 1 264 ? 3.109   -39.305 -40.859 1.00 47.17  ? 527  GLY A CA  1 
ATOM   1835 C  C   . GLY A 1 264 ? 3.955   -40.032 -39.836 1.00 47.23  ? 527  GLY A C   1 
ATOM   1836 O  O   . GLY A 1 264 ? 4.372   -41.183 -40.086 1.00 47.40  ? 527  GLY A O   1 
ATOM   1837 N  N   . GLY A 1 265 ? 4.220   -39.389 -38.703 1.00 51.34  ? 528  GLY A N   1 
ATOM   1838 C  CA  . GLY A 1 265 ? 5.124   -39.962 -37.690 1.00 49.94  ? 528  GLY A CA  1 
ATOM   1839 C  C   . GLY A 1 265 ? 4.377   -40.824 -36.676 1.00 51.86  ? 528  GLY A C   1 
ATOM   1840 O  O   . GLY A 1 265 ? 3.338   -41.460 -37.020 1.00 44.30  ? 528  GLY A O   1 
ATOM   1841 N  N   . ALA A 1 266 ? 4.898   -40.857 -35.456 1.00 38.39  ? 529  ALA A N   1 
ATOM   1842 C  CA  . ALA A 1 266 ? 4.320   -41.614 -34.340 1.00 39.21  ? 529  ALA A CA  1 
ATOM   1843 C  C   . ALA A 1 266 ? 2.947   -41.010 -34.020 1.00 37.79  ? 529  ALA A C   1 
ATOM   1844 O  O   . ALA A 1 266 ? 2.662   -39.892 -34.459 1.00 39.54  ? 529  ALA A O   1 
ATOM   1845 C  CB  . ALA A 1 266 ? 5.271   -41.548 -33.153 1.00 36.62  ? 529  ALA A CB  1 
ATOM   1846 N  N   . MET A 1 267 ? 2.143   -41.716 -33.244 1.00 34.85  ? 530  MET A N   1 
ATOM   1847 C  CA  . MET A 1 267 ? 0.914   -41.179 -32.643 1.00 34.85  ? 530  MET A CA  1 
ATOM   1848 C  C   . MET A 1 267 ? 1.281   -40.675 -31.242 1.00 32.43  ? 530  MET A C   1 
ATOM   1849 O  O   . MET A 1 267 ? 1.960   -41.391 -30.521 1.00 38.99  ? 530  MET A O   1 
ATOM   1850 C  CB  . MET A 1 267 ? -0.158  -42.272 -32.618 1.00 38.16  ? 530  MET A CB  1 
ATOM   1851 C  CG  . MET A 1 267 ? -0.590  -42.715 -34.022 1.00 39.98  ? 530  MET A CG  1 
ATOM   1852 S  SD  . MET A 1 267 ? -1.953  -43.928 -34.054 1.00 46.53  ? 530  MET A SD  1 
ATOM   1853 C  CE  . MET A 1 267 ? -3.382  -42.914 -33.704 1.00 49.14  ? 530  MET A CE  1 
ATOM   1854 N  N   . TYR A 1 268 ? 0.914   -39.448 -30.906 1.00 32.11  ? 531  TYR A N   1 
ATOM   1855 C  CA  . TYR A 1 268 ? 1.274   -38.791 -29.635 1.00 32.28  ? 531  TYR A CA  1 
ATOM   1856 C  C   . TYR A 1 268 ? 0.001   -38.666 -28.819 1.00 34.67  ? 531  TYR A C   1 
ATOM   1857 O  O   . TYR A 1 268 ? -1.022  -38.273 -29.374 1.00 35.25  ? 531  TYR A O   1 
ATOM   1858 C  CB  . TYR A 1 268 ? 1.965   -37.444 -29.869 1.00 34.09  ? 531  TYR A CB  1 
ATOM   1859 C  CG  . TYR A 1 268 ? 3.285   -37.571 -30.576 1.00 35.15  ? 531  TYR A CG  1 
ATOM   1860 C  CD1 . TYR A 1 268 ? 3.343   -37.725 -31.952 1.00 33.06  ? 531  TYR A CD1 1 
ATOM   1861 C  CD2 . TYR A 1 268 ? 4.471   -37.634 -29.859 1.00 35.10  ? 531  TYR A CD2 1 
ATOM   1862 C  CE1 . TYR A 1 268 ? 4.557   -37.904 -32.597 1.00 36.81  ? 531  TYR A CE1 1 
ATOM   1863 C  CE2 . TYR A 1 268 ? 5.688   -37.821 -30.491 1.00 35.57  ? 531  TYR A CE2 1 
ATOM   1864 C  CZ  . TYR A 1 268 ? 5.732   -37.947 -31.865 1.00 35.94  ? 531  TYR A CZ  1 
ATOM   1865 O  OH  . TYR A 1 268 ? 6.923   -38.163 -32.492 1.00 34.48  ? 531  TYR A OH  1 
ATOM   1866 N  N   . ALA A 1 269 ? 0.100   -38.985 -27.534 1.00 34.20  ? 532  ALA A N   1 
ATOM   1867 C  CA  . ALA A 1 269 ? -1.003  -38.903 -26.586 1.00 32.74  ? 532  ALA A CA  1 
ATOM   1868 C  C   . ALA A 1 269 ? -0.458  -38.337 -25.295 1.00 36.73  ? 532  ALA A C   1 
ATOM   1869 O  O   . ALA A 1 269 ? -0.522  -39.034 -24.319 1.00 40.37  ? 532  ALA A O   1 
ATOM   1870 C  CB  . ALA A 1 269 ? -1.612  -40.254 -26.421 1.00 34.88  ? 532  ALA A CB  1 
ATOM   1871 N  N   . ASP A 1 270 ? -0.027  -37.078 -25.298 1.00 35.69  ? 533  ASP A N   1 
ATOM   1872 C  CA  . ASP A 1 270 ? 0.445   -36.386 -24.077 1.00 35.71  ? 533  ASP A CA  1 
ATOM   1873 C  C   . ASP A 1 270 ? -0.770  -35.935 -23.289 1.00 41.63  ? 533  ASP A C   1 
ATOM   1874 O  O   . ASP A 1 270 ? -1.561  -35.194 -23.859 1.00 47.08  ? 533  ASP A O   1 
ATOM   1875 C  CB  . ASP A 1 270 ? 1.373   -35.214 -24.413 1.00 39.25  ? 533  ASP A CB  1 
ATOM   1876 C  CG  . ASP A 1 270 ? 2.621   -35.650 -25.175 1.00 43.43  ? 533  ASP A CG  1 
ATOM   1877 O  OD1 . ASP A 1 270 ? 3.016   -36.845 -25.025 1.00 48.10  ? 533  ASP A OD1 1 
ATOM   1878 O  OD2 . ASP A 1 270 ? 3.131   -34.852 -25.989 1.00 41.83  ? 533  ASP A OD2 1 
ATOM   1879 N  N   . ASP A 1 271 ? -0.899  -36.395 -22.042 1.00 43.64  ? 534  ASP A N   1 
ATOM   1880 C  CA  . ASP A 1 271 ? -1.868  -35.882 -21.038 1.00 45.92  ? 534  ASP A CA  1 
ATOM   1881 C  C   . ASP A 1 271 ? -1.337  -34.560 -20.477 1.00 46.68  ? 534  ASP A C   1 
ATOM   1882 O  O   . ASP A 1 271 ? -0.139  -34.469 -20.288 1.00 43.92  ? 534  ASP A O   1 
ATOM   1883 C  CB  . ASP A 1 271 ? -2.087  -36.866 -19.885 1.00 49.53  ? 534  ASP A CB  1 
ATOM   1884 C  CG  . ASP A 1 271 ? -3.054  -37.997 -20.174 1.00 59.83  ? 534  ASP A CG  1 
ATOM   1885 O  OD1 . ASP A 1 271 ? -3.666  -37.994 -21.280 1.00 60.44  ? 534  ASP A OD1 1 
ATOM   1886 O  OD2 . ASP A 1 271 ? -3.236  -38.848 -19.267 1.00 70.20  ? 534  ASP A OD2 1 
ATOM   1887 N  N   . THR A 1 272 ? -2.220  -33.604 -20.161 1.00 44.37  ? 535  THR A N   1 
ATOM   1888 C  CA  . THR A 1 272 ? -1.862  -32.327 -19.508 1.00 39.30  ? 535  THR A CA  1 
ATOM   1889 C  C   . THR A 1 272 ? -1.982  -32.492 -18.004 1.00 43.44  ? 535  THR A C   1 
ATOM   1890 O  O   . THR A 1 272 ? -2.944  -33.149 -17.567 1.00 50.91  ? 535  THR A O   1 
ATOM   1891 C  CB  . THR A 1 272 ? -2.746  -31.174 -19.976 1.00 40.36  ? 535  THR A CB  1 
ATOM   1892 O  OG1 . THR A 1 272 ? -2.435  -30.945 -21.343 1.00 43.22  ? 535  THR A OG1 1 
ATOM   1893 C  CG2 . THR A 1 272 ? -2.491  -29.875 -19.235 1.00 41.61  ? 535  THR A CG2 1 
ATOM   1894 N  N   . ALA A 1 273 ? -1.086  -31.848 -17.256 1.00 48.70  ? 536  ALA A N   1 
ATOM   1895 C  CA  . ALA A 1 273 ? -1.086  -31.808 -15.770 1.00 55.12  ? 536  ALA A CA  1 
ATOM   1896 C  C   . ALA A 1 273 ? -2.167  -30.833 -15.248 1.00 51.07  ? 536  ALA A C   1 
ATOM   1897 O  O   . ALA A 1 273 ? -1.933  -29.618 -15.299 1.00 55.11  ? 536  ALA A O   1 
ATOM   1898 C  CB  . ALA A 1 273 ? 0.307   -31.431 -15.305 1.00 51.97  ? 536  ALA A CB  1 
ATOM   1899 N  N   . GLY A 1 274 ? -3.302  -31.358 -14.776 1.00 48.55  ? 537  GLY A N   1 
ATOM   1900 C  CA  . GLY A 1 274 ? -4.436  -30.586 -14.226 1.00 51.12  ? 537  GLY A CA  1 
ATOM   1901 C  C   . GLY A 1 274 ? -4.977  -29.541 -15.197 1.00 50.70  ? 537  GLY A C   1 
ATOM   1902 O  O   . GLY A 1 274 ? -4.976  -28.348 -14.839 1.00 46.58  ? 537  GLY A O   1 
ATOM   1903 N  N   . TRP A 1 275 ? -5.457  -29.992 -16.362 1.00 45.40  ? 538  TRP A N   1 
ATOM   1904 C  CA  . TRP A 1 275 ? -5.987  -29.165 -17.478 1.00 42.94  ? 538  TRP A CA  1 
ATOM   1905 C  C   . TRP A 1 275 ? -6.916  -28.028 -17.010 1.00 37.30  ? 538  TRP A C   1 
ATOM   1906 O  O   . TRP A 1 275 ? -6.702  -26.900 -17.438 1.00 36.97  ? 538  TRP A O   1 
ATOM   1907 C  CB  . TRP A 1 275 ? -6.712  -30.042 -18.494 1.00 39.16  ? 538  TRP A CB  1 
ATOM   1908 C  CG  . TRP A 1 275 ? -7.340  -29.209 -19.568 1.00 39.02  ? 538  TRP A CG  1 
ATOM   1909 C  CD1 . TRP A 1 275 ? -8.558  -28.598 -19.532 1.00 39.93  ? 538  TRP A CD1 1 
ATOM   1910 C  CD2 . TRP A 1 275 ? -6.789  -28.909 -20.853 1.00 37.27  ? 538  TRP A CD2 1 
ATOM   1911 N  NE1 . TRP A 1 275 ? -8.801  -27.940 -20.705 1.00 42.27  ? 538  TRP A NE1 1 
ATOM   1912 C  CE2 . TRP A 1 275 ? -7.720  -28.084 -21.519 1.00 38.31  ? 538  TRP A CE2 1 
ATOM   1913 C  CE3 . TRP A 1 275 ? -5.616  -29.256 -21.508 1.00 36.57  ? 538  TRP A CE3 1 
ATOM   1914 C  CZ2 . TRP A 1 275 ? -7.501  -27.598 -22.797 1.00 35.99  ? 538  TRP A CZ2 1 
ATOM   1915 C  CZ3 . TRP A 1 275 ? -5.398  -28.761 -22.771 1.00 37.74  ? 538  TRP A CZ3 1 
ATOM   1916 C  CH2 . TRP A 1 275 ? -6.347  -27.983 -23.420 1.00 36.80  ? 538  TRP A CH2 1 
ATOM   1917 N  N   . ASP A 1 276 ? -7.928  -28.300 -16.205 1.00 38.59  ? 539  ASP A N   1 
ATOM   1918 C  CA  . ASP A 1 276 ? -8.939  -27.276 -15.793 1.00 45.33  ? 539  ASP A CA  1 
ATOM   1919 C  C   . ASP A 1 276 ? -8.253  -26.125 -15.047 1.00 51.30  ? 539  ASP A C   1 
ATOM   1920 O  O   . ASP A 1 276 ? -8.678  -24.952 -15.262 1.00 46.08  ? 539  ASP A O   1 
ATOM   1921 C  CB  . ASP A 1 276 ? -10.069 -27.879 -14.964 1.00 47.75  ? 539  ASP A CB  1 
ATOM   1922 C  CG  . ASP A 1 276 ? -11.088 -28.640 -15.803 1.00 49.05  ? 539  ASP A CG  1 
ATOM   1923 O  OD1 . ASP A 1 276 ? -10.873 -28.727 -17.000 1.00 51.40  ? 539  ASP A OD1 1 
ATOM   1924 O  OD2 . ASP A 1 276 ? -12.102 -29.124 -15.249 1.00 59.74  ? 539  ASP A OD2 1 
ATOM   1925 N  N   . THR A 1 277 ? -7.188  -26.411 -14.282 1.00 47.18  ? 540  THR A N   1 
ATOM   1926 C  CA  . THR A 1 277 ? -6.478  -25.373 -13.490 1.00 48.01  ? 540  THR A CA  1 
ATOM   1927 C  C   . THR A 1 277 ? -5.524  -24.581 -14.385 1.00 46.18  ? 540  THR A C   1 
ATOM   1928 O  O   . THR A 1 277 ? -5.021  -23.593 -13.888 1.00 47.49  ? 540  THR A O   1 
ATOM   1929 C  CB  . THR A 1 277 ? -5.739  -25.929 -12.261 1.00 48.36  ? 540  THR A CB  1 
ATOM   1930 O  OG1 . THR A 1 277 ? -4.687  -26.804 -12.658 1.00 49.37  ? 540  THR A OG1 1 
ATOM   1931 C  CG2 . THR A 1 277 ? -6.671  -26.635 -11.305 1.00 50.95  ? 540  THR A CG2 1 
ATOM   1932 N  N   . ARG A 1 278 ? -5.298  -24.982 -15.642 1.00 43.98  ? 541  ARG A N   1 
ATOM   1933 C  CA  . ARG A 1 278 ? -4.355  -24.310 -16.583 1.00 41.24  ? 541  ARG A CA  1 
ATOM   1934 C  C   . ARG A 1 278 ? -5.091  -23.502 -17.639 1.00 38.38  ? 541  ARG A C   1 
ATOM   1935 O  O   . ARG A 1 278 ? -4.405  -23.108 -18.576 1.00 40.91  ? 541  ARG A O   1 
ATOM   1936 C  CB  . ARG A 1 278 ? -3.506  -25.316 -17.371 1.00 49.19  ? 541  ARG A CB  1 
ATOM   1937 C  CG  . ARG A 1 278 ? -2.874  -26.404 -16.517 1.00 56.28  ? 541  ARG A CG  1 
ATOM   1938 C  CD  . ARG A 1 278 ? -1.507  -26.000 -16.040 1.00 61.17  ? 541  ARG A CD  1 
ATOM   1939 N  NE  . ARG A 1 278 ? -0.894  -26.978 -15.139 1.00 72.55  ? 541  ARG A NE  1 
ATOM   1940 C  CZ  . ARG A 1 278 ? 0.382   -26.951 -14.750 1.00 71.47  ? 541  ARG A CZ  1 
ATOM   1941 N  NH1 . ARG A 1 278 ? 1.209   -26.036 -15.226 1.00 70.84  ? 541  ARG A NH1 1 
ATOM   1942 N  NH2 . ARG A 1 278 ? 0.835   -27.852 -13.902 1.00 71.89  ? 541  ARG A NH2 1 
ATOM   1943 N  N   . ILE A 1 279 ? -6.426  -23.401 -17.578 1.00 39.62  ? 542  ILE A N   1 
ATOM   1944 C  CA  . ILE A 1 279 ? -7.226  -22.571 -18.538 1.00 41.66  ? 542  ILE A CA  1 
ATOM   1945 C  C   . ILE A 1 279 ? -6.990  -21.094 -18.172 1.00 36.81  ? 542  ILE A C   1 
ATOM   1946 O  O   . ILE A 1 279 ? -7.282  -20.676 -17.039 1.00 37.22  ? 542  ILE A O   1 
ATOM   1947 C  CB  . ILE A 1 279 ? -8.714  -22.994 -18.528 1.00 41.22  ? 542  ILE A CB  1 
ATOM   1948 C  CG1 . ILE A 1 279 ? -8.958  -24.299 -19.285 1.00 42.84  ? 542  ILE A CG1 1 
ATOM   1949 C  CG2 . ILE A 1 279 ? -9.614  -21.901 -19.066 1.00 39.51  ? 542  ILE A CG2 1 
ATOM   1950 C  CD1 . ILE A 1 279 ? -8.764  -24.160 -20.773 1.00 47.44  ? 542  ILE A CD1 1 
ATOM   1951 N  N   . THR A 1 280 ? -6.397  -20.347 -19.079 1.00 41.15  ? 543  THR A N   1 
ATOM   1952 C  CA  . THR A 1 280 ? -5.989  -18.935 -18.874 1.00 43.82  ? 543  THR A CA  1 
ATOM   1953 C  C   . THR A 1 280 ? -7.177  -18.051 -19.237 1.00 48.73  ? 543  THR A C   1 
ATOM   1954 O  O   . THR A 1 280 ? -8.071  -18.539 -19.982 1.00 53.40  ? 543  THR A O   1 
ATOM   1955 C  CB  . THR A 1 280 ? -4.722  -18.625 -19.674 1.00 42.51  ? 543  THR A CB  1 
ATOM   1956 O  OG1 . THR A 1 280 ? -4.989  -18.635 -21.080 1.00 47.42  ? 543  THR A OG1 1 
ATOM   1957 C  CG2 . THR A 1 280 ? -3.626  -19.626 -19.382 1.00 44.65  ? 543  THR A CG2 1 
ATOM   1958 N  N   . LEU A 1 281 ? -7.230  -16.835 -18.687 1.00 51.53  ? 544  LEU A N   1 
ATOM   1959 C  CA  . LEU A 1 281 ? -8.242  -15.823 -19.088 1.00 55.66  ? 544  LEU A CA  1 
ATOM   1960 C  C   . LEU A 1 281 ? -8.172  -15.625 -20.613 1.00 48.33  ? 544  LEU A C   1 
ATOM   1961 O  O   . LEU A 1 281 ? -9.214  -15.455 -21.217 1.00 51.31  ? 544  LEU A O   1 
ATOM   1962 C  CB  . LEU A 1 281 ? -8.013  -14.519 -18.318 1.00 67.19  ? 544  LEU A CB  1 
ATOM   1963 C  CG  . LEU A 1 281 ? -8.911  -13.355 -18.740 1.00 71.58  ? 544  LEU A CG  1 
ATOM   1964 C  CD1 . LEU A 1 281 ? -10.387 -13.755 -18.720 1.00 61.79  ? 544  LEU A CD1 1 
ATOM   1965 C  CD2 . LEU A 1 281 ? -8.661  -12.139 -17.857 1.00 74.07  ? 544  LEU A CD2 1 
ATOM   1966 N  N   . GLU A 1 282 ? -7.005  -15.771 -21.237 1.00 54.59  ? 545  GLU A N   1 
ATOM   1967 C  CA  . GLU A 1 282 ? -6.866  -15.679 -22.723 1.00 56.91  ? 545  GLU A CA  1 
ATOM   1968 C  C   . GLU A 1 282 ? -7.644  -16.831 -23.394 1.00 53.53  ? 545  GLU A C   1 
ATOM   1969 O  O   . GLU A 1 282 ? -8.300  -16.608 -24.472 1.00 48.20  ? 545  GLU A O   1 
ATOM   1970 C  CB  . GLU A 1 282 ? -5.377  -15.634 -23.093 1.00 64.66  ? 545  GLU A CB  1 
ATOM   1971 C  CG  . GLU A 1 282 ? -5.075  -14.758 -24.295 1.00 71.55  ? 545  GLU A CG  1 
ATOM   1972 C  CD  . GLU A 1 282 ? -5.464  -13.291 -24.162 1.00 77.38  ? 545  GLU A CD  1 
ATOM   1973 O  OE1 . GLU A 1 282 ? -5.440  -12.752 -23.021 1.00 79.66  ? 545  GLU A OE1 1 
ATOM   1974 O  OE2 . GLU A 1 282 ? -5.805  -12.695 -25.198 1.00 74.21  ? 545  GLU A OE2 1 
ATOM   1975 N  N   . ASP A 1 283 ? -7.605  -18.016 -22.782 1.00 49.30  ? 546  ASP A N   1 
ATOM   1976 C  CA  . ASP A 1 283 ? -8.398  -19.193 -23.227 1.00 51.40  ? 546  ASP A CA  1 
ATOM   1977 C  C   . ASP A 1 283 ? -9.892  -18.845 -23.093 1.00 48.80  ? 546  ASP A C   1 
ATOM   1978 O  O   . ASP A 1 283 ? -10.634 -19.022 -24.078 1.00 43.54  ? 546  ASP A O   1 
ATOM   1979 C  CB  . ASP A 1 283 ? -8.027  -20.479 -22.470 1.00 45.31  ? 546  ASP A CB  1 
ATOM   1980 C  CG  . ASP A 1 283 ? -6.609  -20.998 -22.705 1.00 46.37  ? 546  ASP A CG  1 
ATOM   1981 O  OD1 . ASP A 1 283 ? -6.140  -20.988 -23.863 1.00 42.64  ? 546  ASP A OD1 1 
ATOM   1982 O  OD2 . ASP A 1 283 ? -5.985  -21.445 -21.712 1.00 50.98  ? 546  ASP A OD2 1 
ATOM   1983 N  N   . LEU A 1 284 ? -10.309 -18.374 -21.916 1.00 44.00  ? 547  LEU A N   1 
ATOM   1984 C  CA  . LEU A 1 284 ? -11.715 -17.969 -21.635 1.00 44.04  ? 547  LEU A CA  1 
ATOM   1985 C  C   . LEU A 1 284 ? -12.190 -16.918 -22.655 1.00 44.12  ? 547  LEU A C   1 
ATOM   1986 O  O   . LEU A 1 284 ? -13.338 -17.016 -23.109 1.00 45.87  ? 547  LEU A O   1 
ATOM   1987 C  CB  . LEU A 1 284 ? -11.795 -17.481 -20.187 1.00 41.74  ? 547  LEU A CB  1 
ATOM   1988 C  CG  . LEU A 1 284 ? -11.635 -18.589 -19.145 1.00 45.29  ? 547  LEU A CG  1 
ATOM   1989 C  CD1 . LEU A 1 284 ? -11.699 -18.077 -17.702 1.00 50.94  ? 547  LEU A CD1 1 
ATOM   1990 C  CD2 . LEU A 1 284 ? -12.675 -19.676 -19.335 1.00 41.26  ? 547  LEU A CD2 1 
ATOM   1991 N  N   . LYS A 1 285 ? -11.318 -16.006 -23.088 1.00 48.21  ? 548  LYS A N   1 
ATOM   1992 C  CA  . LYS A 1 285 ? -11.653 -14.943 -24.068 1.00 51.16  ? 548  LYS A CA  1 
ATOM   1993 C  C   . LYS A 1 285 ? -11.770 -15.541 -25.472 1.00 49.80  ? 548  LYS A C   1 
ATOM   1994 O  O   . LYS A 1 285 ? -12.665 -15.105 -26.204 1.00 50.48  ? 548  LYS A O   1 
ATOM   1995 C  CB  . LYS A 1 285 ? -10.632 -13.802 -24.018 1.00 51.59  ? 548  LYS A CB  1 
ATOM   1996 C  CG  . LYS A 1 285 ? -10.789 -12.884 -22.815 1.00 62.48  ? 548  LYS A CG  1 
ATOM   1997 C  CD  . LYS A 1 285 ? -10.038 -11.562 -22.933 1.00 71.86  ? 548  LYS A CD  1 
ATOM   1998 C  CE  . LYS A 1 285 ? -10.451 -10.573 -21.861 1.00 74.55  ? 548  LYS A CE  1 
ATOM   1999 N  NZ  . LYS A 1 285 ? -9.387  -9.571  -21.617 1.00 85.32  ? 548  LYS A NZ  1 
ATOM   2000 N  N   . ASN A 1 286 ? -10.914 -16.479 -25.857 1.00 41.39  ? 549  ASN A N   1 
ATOM   2001 C  CA  . ASN A 1 286 ? -11.039 -17.135 -27.186 1.00 45.96  ? 549  ASN A CA  1 
ATOM   2002 C  C   . ASN A 1 286 ? -12.280 -18.037 -27.251 1.00 41.01  ? 549  ASN A C   1 
ATOM   2003 O  O   . ASN A 1 286 ? -12.858 -18.168 -28.358 1.00 38.73  ? 549  ASN A O   1 
ATOM   2004 C  CB  . ASN A 1 286 ? -9.782  -17.924 -27.527 1.00 51.77  ? 549  ASN A CB  1 
ATOM   2005 C  CG  . ASN A 1 286 ? -8.610  -17.002 -27.773 1.00 55.11  ? 549  ASN A CG  1 
ATOM   2006 O  OD1 . ASN A 1 286 ? -8.769  -15.930 -28.353 1.00 45.74  ? 549  ASN A OD1 1 
ATOM   2007 N  ND2 . ASN A 1 286 ? -7.431  -17.434 -27.373 1.00 62.04  ? 549  ASN A ND2 1 
ATOM   2008 N  N   . GLU A 1 287 ? -12.661 -18.660 -26.131 1.00 40.17  ? 550  GLU A N   1 
ATOM   2009 C  CA  . GLU A 1 287 ? -13.905 -19.483 -26.014 1.00 40.87  ? 550  GLU A CA  1 
ATOM   2010 C  C   . GLU A 1 287 ? -15.148 -18.592 -26.229 1.00 38.25  ? 550  GLU A C   1 
ATOM   2011 O  O   . GLU A 1 287 ? -16.075 -19.035 -26.927 1.00 41.70  ? 550  GLU A O   1 
ATOM   2012 C  CB  . GLU A 1 287 ? -13.913 -20.230 -24.671 1.00 41.42  ? 550  GLU A CB  1 
ATOM   2013 C  CG  . GLU A 1 287 ? -12.879 -21.349 -24.622 1.00 46.11  ? 550  GLU A CG  1 
ATOM   2014 C  CD  . GLU A 1 287 ? -12.581 -21.982 -23.271 1.00 47.47  ? 550  GLU A CD  1 
ATOM   2015 O  OE1 . GLU A 1 287 ? -13.299 -21.685 -22.278 1.00 43.63  ? 550  GLU A OE1 1 
ATOM   2016 O  OE2 . GLU A 1 287 ? -11.654 -22.829 -23.229 1.00 44.65  ? 550  GLU A OE2 1 
ATOM   2017 N  N   . GLU A 1 288 ? -15.154 -17.398 -25.638 1.00 35.85  ? 551  GLU A N   1 
ATOM   2018 C  CA  . GLU A 1 288 ? -16.245 -16.390 -25.693 1.00 39.88  ? 551  GLU A CA  1 
ATOM   2019 C  C   . GLU A 1 288 ? -16.507 -15.965 -27.134 1.00 37.23  ? 551  GLU A C   1 
ATOM   2020 O  O   . GLU A 1 288 ? -17.595 -15.499 -27.366 1.00 42.85  ? 551  GLU A O   1 
ATOM   2021 C  CB  . GLU A 1 288 ? -15.902 -15.148 -24.864 1.00 47.84  ? 551  GLU A CB  1 
ATOM   2022 C  CG  . GLU A 1 288 ? -17.066 -14.216 -24.561 1.00 51.66  ? 551  GLU A CG  1 
ATOM   2023 C  CD  . GLU A 1 288 ? -17.296 -12.991 -25.452 1.00 62.04  ? 551  GLU A CD  1 
ATOM   2024 O  OE1 . GLU A 1 288 ? -16.555 -12.797 -26.450 1.00 57.17  ? 551  GLU A OE1 1 
ATOM   2025 O  OE2 . GLU A 1 288 ? -18.236 -12.215 -25.139 1.00 67.84  ? 551  GLU A OE2 1 
ATOM   2026 N  N   . MET A 1 289 ? -15.605 -16.195 -28.085 1.00 37.79  ? 552  MET A N   1 
ATOM   2027 C  CA  . MET A 1 289 ? -15.795 -15.701 -29.469 1.00 39.75  ? 552  MET A CA  1 
ATOM   2028 C  C   . MET A 1 289 ? -16.868 -16.518 -30.165 1.00 44.26  ? 552  MET A C   1 
ATOM   2029 O  O   . MET A 1 289 ? -17.263 -16.117 -31.283 1.00 50.13  ? 552  MET A O   1 
ATOM   2030 C  CB  . MET A 1 289 ? -14.498 -15.731 -30.280 1.00 44.35  ? 552  MET A CB  1 
ATOM   2031 C  CG  . MET A 1 289 ? -13.475 -14.757 -29.717 1.00 48.37  ? 552  MET A CG  1 
ATOM   2032 S  SD  . MET A 1 289 ? -12.089 -14.447 -30.826 1.00 59.92  ? 552  MET A SD  1 
ATOM   2033 C  CE  . MET A 1 289 ? -12.109 -15.850 -31.933 1.00 58.07  ? 552  MET A CE  1 
ATOM   2034 N  N   . VAL A 1 290 ? -17.366 -17.596 -29.541 1.00 46.10  ? 553  VAL A N   1 
ATOM   2035 C  CA  . VAL A 1 290 ? -18.596 -18.292 -30.045 1.00 41.35  ? 553  VAL A CA  1 
ATOM   2036 C  C   . VAL A 1 290 ? -19.790 -17.302 -30.068 1.00 42.04  ? 553  VAL A C   1 
ATOM   2037 O  O   . VAL A 1 290 ? -20.668 -17.480 -30.935 1.00 47.69  ? 553  VAL A O   1 
ATOM   2038 C  CB  . VAL A 1 290 ? -18.899 -19.572 -29.244 1.00 36.38  ? 553  VAL A CB  1 
ATOM   2039 C  CG1 . VAL A 1 290 ? -19.271 -19.319 -27.788 1.00 35.55  ? 553  VAL A CG1 1 
ATOM   2040 C  CG2 . VAL A 1 290 ? -19.968 -20.395 -29.924 1.00 38.35  ? 553  VAL A CG2 1 
ATOM   2041 N  N   . THR A 1 291 ? -19.853 -16.296 -29.179 1.00 41.06  ? 554  THR A N   1 
ATOM   2042 C  CA  . THR A 1 291 ? -20.974 -15.307 -29.128 1.00 43.79  ? 554  THR A CA  1 
ATOM   2043 C  C   . THR A 1 291 ? -21.005 -14.488 -30.428 1.00 47.28  ? 554  THR A C   1 
ATOM   2044 O  O   . THR A 1 291 ? -22.107 -13.997 -30.809 1.00 45.09  ? 554  THR A O   1 
ATOM   2045 C  CB  . THR A 1 291 ? -20.884 -14.372 -27.921 1.00 42.00  ? 554  THR A CB  1 
ATOM   2046 O  OG1 . THR A 1 291 ? -19.598 -13.738 -27.945 1.00 45.44  ? 554  THR A OG1 1 
ATOM   2047 C  CG2 . THR A 1 291 ? -21.096 -15.088 -26.606 1.00 38.90  ? 554  THR A CG2 1 
ATOM   2048 N  N   . ASN A 1 292 ? -19.874 -14.394 -31.128 1.00 46.08  ? 555  ASN A N   1 
ATOM   2049 C  CA  . ASN A 1 292 ? -19.788 -13.653 -32.418 1.00 48.34  ? 555  ASN A CA  1 
ATOM   2050 C  C   . ASN A 1 292 ? -20.674 -14.297 -33.481 1.00 52.53  ? 555  ASN A C   1 
ATOM   2051 O  O   . ASN A 1 292 ? -20.916 -13.645 -34.528 1.00 58.13  ? 555  ASN A O   1 
ATOM   2052 C  CB  . ASN A 1 292 ? -18.387 -13.580 -33.014 1.00 43.99  ? 555  ASN A CB  1 
ATOM   2053 C  CG  . ASN A 1 292 ? -17.429 -12.820 -32.140 1.00 45.52  ? 555  ASN A CG  1 
ATOM   2054 O  OD1 . ASN A 1 292 ? -17.835 -12.197 -31.177 1.00 57.81  ? 555  ASN A OD1 1 
ATOM   2055 N  ND2 . ASN A 1 292 ? -16.148 -12.915 -32.442 1.00 52.93  ? 555  ASN A ND2 1 
ATOM   2056 N  N   . HIS A 1 293 ? -21.111 -15.529 -33.260 1.00 49.04  ? 556  HIS A N   1 
ATOM   2057 C  CA  . HIS A 1 293 ? -21.926 -16.298 -34.239 1.00 48.77  ? 556  HIS A CA  1 
ATOM   2058 C  C   . HIS A 1 293 ? -23.401 -16.272 -33.838 1.00 41.38  ? 556  HIS A C   1 
ATOM   2059 O  O   . HIS A 1 293 ? -24.197 -16.874 -34.548 1.00 47.11  ? 556  HIS A O   1 
ATOM   2060 C  CB  . HIS A 1 293 ? -21.329 -17.706 -34.370 1.00 50.76  ? 556  HIS A CB  1 
ATOM   2061 C  CG  . HIS A 1 293 ? -19.954 -17.635 -34.923 1.00 56.83  ? 556  HIS A CG  1 
ATOM   2062 N  ND1 . HIS A 1 293 ? -19.695 -17.853 -36.262 1.00 54.42  ? 556  HIS A ND1 1 
ATOM   2063 C  CD2 . HIS A 1 293 ? -18.780 -17.292 -34.340 1.00 58.93  ? 556  HIS A CD2 1 
ATOM   2064 C  CE1 . HIS A 1 293 ? -18.413 -17.663 -36.482 1.00 54.42  ? 556  HIS A CE1 1 
ATOM   2065 N  NE2 . HIS A 1 293 ? -17.832 -17.302 -35.321 1.00 60.09  ? 556  HIS A NE2 1 
ATOM   2066 N  N   . MET A 1 294 ? -23.726 -15.625 -32.719 1.00 44.04  ? 557  MET A N   1 
ATOM   2067 C  CA  . MET A 1 294 ? -25.074 -15.588 -32.099 1.00 45.66  ? 557  MET A CA  1 
ATOM   2068 C  C   . MET A 1 294 ? -25.775 -14.265 -32.445 1.00 47.46  ? 557  MET A C   1 
ATOM   2069 O  O   . MET A 1 294 ? -25.148 -13.400 -33.066 1.00 51.94  ? 557  MET A O   1 
ATOM   2070 C  CB  . MET A 1 294 ? -24.971 -15.708 -30.579 1.00 44.01  ? 557  MET A CB  1 
ATOM   2071 C  CG  . MET A 1 294 ? -24.560 -17.087 -30.098 1.00 44.51  ? 557  MET A CG  1 
ATOM   2072 S  SD  . MET A 1 294 ? -24.323 -17.056 -28.312 1.00 46.09  ? 557  MET A SD  1 
ATOM   2073 C  CE  . MET A 1 294 ? -23.251 -18.484 -28.131 1.00 50.21  ? 557  MET A CE  1 
ATOM   2074 N  N   . GLU A 1 295 ? -27.055 -14.145 -32.091 1.00 55.42  ? 558  GLU A N   1 
ATOM   2075 C  CA  . GLU A 1 295 ? -27.870 -12.916 -32.308 1.00 56.45  ? 558  GLU A CA  1 
ATOM   2076 C  C   . GLU A 1 295 ? -28.935 -12.765 -31.219 1.00 52.68  ? 558  GLU A C   1 
ATOM   2077 O  O   . GLU A 1 295 ? -29.284 -13.765 -30.545 1.00 57.89  ? 558  GLU A O   1 
ATOM   2078 C  CB  . GLU A 1 295 ? -28.519 -12.956 -33.686 1.00 54.56  ? 558  GLU A CB  1 
ATOM   2079 C  CG  . GLU A 1 295 ? -29.570 -14.026 -33.850 1.00 61.09  ? 558  GLU A CG  1 
ATOM   2080 C  CD  . GLU A 1 295 ? -30.194 -14.073 -35.244 1.00 69.53  ? 558  GLU A CD  1 
ATOM   2081 O  OE1 . GLU A 1 295 ? -29.515 -14.482 -36.230 1.00 68.94  ? 558  GLU A OE1 1 
ATOM   2082 O  OE2 . GLU A 1 295 ? -31.359 -13.673 -35.347 1.00 78.26  ? 558  GLU A OE2 1 
ATOM   2083 N  N   . GLY A 1 296 ? -29.395 -11.530 -31.046 1.00 55.77  ? 559  GLY A N   1 
ATOM   2084 C  CA  . GLY A 1 296 ? -30.594 -11.196 -30.261 1.00 55.19  ? 559  GLY A CA  1 
ATOM   2085 C  C   . GLY A 1 296 ? -30.361 -11.370 -28.776 1.00 55.61  ? 559  GLY A C   1 
ATOM   2086 O  O   . GLY A 1 296 ? -29.289 -10.931 -28.275 1.00 55.19  ? 559  GLY A O   1 
ATOM   2087 N  N   . GLU A 1 297 ? -31.355 -11.956 -28.110 1.00 54.93  ? 560  GLU A N   1 
ATOM   2088 C  CA  . GLU A 1 297 ? -31.353 -12.306 -26.666 1.00 60.06  ? 560  GLU A CA  1 
ATOM   2089 C  C   . GLU A 1 297 ? -30.223 -13.317 -26.394 1.00 59.11  ? 560  GLU A C   1 
ATOM   2090 O  O   . GLU A 1 297 ? -29.368 -13.050 -25.527 1.00 62.36  ? 560  GLU A O   1 
ATOM   2091 C  CB  . GLU A 1 297 ? -32.717 -12.893 -26.307 1.00 60.82  ? 560  GLU A CB  1 
ATOM   2092 C  CG  . GLU A 1 297 ? -33.103 -12.691 -24.864 1.00 69.83  ? 560  GLU A CG  1 
ATOM   2093 C  CD  . GLU A 1 297 ? -34.556 -13.035 -24.618 1.00 78.75  ? 560  GLU A CD  1 
ATOM   2094 O  OE1 . GLU A 1 297 ? -34.895 -14.239 -24.700 1.00 74.39  ? 560  GLU A OE1 1 
ATOM   2095 O  OE2 . GLU A 1 297 ? -35.344 -12.092 -24.376 1.00 94.16  ? 560  GLU A OE2 1 
ATOM   2096 N  N   . HIS A 1 298 ? -30.215 -14.426 -27.134 1.00 58.76  ? 561  HIS A N   1 
ATOM   2097 C  CA  . HIS A 1 298 ? -29.182 -15.491 -27.055 1.00 57.95  ? 561  HIS A CA  1 
ATOM   2098 C  C   . HIS A 1 298 ? -27.800 -14.854 -26.902 1.00 56.58  ? 561  HIS A C   1 
ATOM   2099 O  O   . HIS A 1 298 ? -27.119 -15.118 -25.872 1.00 55.98  ? 561  HIS A O   1 
ATOM   2100 C  CB  . HIS A 1 298 ? -29.236 -16.408 -28.273 1.00 52.99  ? 561  HIS A CB  1 
ATOM   2101 C  CG  . HIS A 1 298 ? -28.362 -17.600 -28.118 1.00 55.82  ? 561  HIS A CG  1 
ATOM   2102 N  ND1 . HIS A 1 298 ? -27.965 -18.366 -29.201 1.00 56.14  ? 561  HIS A ND1 1 
ATOM   2103 C  CD2 . HIS A 1 298 ? -27.810 -18.156 -27.011 1.00 50.52  ? 561  HIS A CD2 1 
ATOM   2104 C  CE1 . HIS A 1 298 ? -27.197 -19.344 -28.767 1.00 58.82  ? 561  HIS A CE1 1 
ATOM   2105 N  NE2 . HIS A 1 298 ? -27.087 -19.235 -27.423 1.00 55.17  ? 561  HIS A NE2 1 
ATOM   2106 N  N   . LYS A 1 299 ? -27.418 -13.999 -27.847 1.00 52.12  ? 562  LYS A N   1 
ATOM   2107 C  CA  . LYS A 1 299 ? -26.095 -13.344 -27.806 1.00 49.86  ? 562  LYS A CA  1 
ATOM   2108 C  C   . LYS A 1 299 ? -25.895 -12.670 -26.439 1.00 57.74  ? 562  LYS A C   1 
ATOM   2109 O  O   . LYS A 1 299 ? -24.793 -12.812 -25.860 1.00 62.83  ? 562  LYS A O   1 
ATOM   2110 C  CB  . LYS A 1 299 ? -25.938 -12.363 -28.958 1.00 47.35  ? 562  LYS A CB  1 
ATOM   2111 C  CG  . LYS A 1 299 ? -24.607 -11.628 -28.929 1.00 50.32  ? 562  LYS A CG  1 
ATOM   2112 C  CD  . LYS A 1 299 ? -24.176 -11.121 -30.279 1.00 51.08  ? 562  LYS A CD  1 
ATOM   2113 C  CE  . LYS A 1 299 ? -23.027 -10.149 -30.186 1.00 55.42  ? 562  LYS A CE  1 
ATOM   2114 N  NZ  . LYS A 1 299 ? -21.953 -10.512 -31.132 1.00 68.90  ? 562  LYS A NZ  1 
ATOM   2115 N  N   . LYS A 1 300 ? -26.906 -11.972 -25.921 1.00 62.07  ? 563  LYS A N   1 
ATOM   2116 C  CA  . LYS A 1 300 ? -26.772 -11.199 -24.656 1.00 62.25  ? 563  LYS A CA  1 
ATOM   2117 C  C   . LYS A 1 300 ? -26.641 -12.196 -23.512 1.00 52.45  ? 563  LYS A C   1 
ATOM   2118 O  O   . LYS A 1 300 ? -25.814 -11.971 -22.641 1.00 54.05  ? 563  LYS A O   1 
ATOM   2119 C  CB  . LYS A 1 300 ? -27.967 -10.274 -24.371 1.00 72.53  ? 563  LYS A CB  1 
ATOM   2120 C  CG  . LYS A 1 300 ? -28.034 -8.971  -25.164 1.00 81.21  ? 563  LYS A CG  1 
ATOM   2121 C  CD  . LYS A 1 300 ? -26.908 -7.997  -24.873 1.00 94.64  ? 563  LYS A CD  1 
ATOM   2122 C  CE  . LYS A 1 300 ? -26.269 -7.436  -26.130 1.00 105.10 ? 563  LYS A CE  1 
ATOM   2123 N  NZ  . LYS A 1 300 ? -25.209 -6.444  -25.824 1.00 110.52 ? 563  LYS A NZ  1 
ATOM   2124 N  N   . LEU A 1 301 ? -27.456 -13.246 -23.511 1.00 50.11  ? 564  LEU A N   1 
ATOM   2125 C  CA  . LEU A 1 301 ? -27.433 -14.258 -22.423 1.00 54.58  ? 564  LEU A CA  1 
ATOM   2126 C  C   . LEU A 1 301 ? -26.057 -14.970 -22.405 1.00 60.74  ? 564  LEU A C   1 
ATOM   2127 O  O   . LEU A 1 301 ? -25.398 -14.914 -21.338 1.00 56.65  ? 564  LEU A O   1 
ATOM   2128 C  CB  . LEU A 1 301 ? -28.626 -15.204 -22.592 1.00 52.39  ? 564  LEU A CB  1 
ATOM   2129 C  CG  . LEU A 1 301 ? -30.006 -14.569 -22.384 1.00 49.95  ? 564  LEU A CG  1 
ATOM   2130 C  CD1 . LEU A 1 301 ? -31.110 -15.555 -22.694 1.00 49.30  ? 564  LEU A CD1 1 
ATOM   2131 C  CD2 . LEU A 1 301 ? -30.168 -14.055 -20.969 1.00 50.65  ? 564  LEU A CD2 1 
ATOM   2132 N  N   . ALA A 1 302 ? -25.574 -15.520 -23.538 1.00 55.57  ? 565  ALA A N   1 
ATOM   2133 C  CA  . ALA A 1 302 ? -24.245 -16.177 -23.640 1.00 49.40  ? 565  ALA A CA  1 
ATOM   2134 C  C   . ALA A 1 302 ? -23.119 -15.208 -23.244 1.00 53.82  ? 565  ALA A C   1 
ATOM   2135 O  O   . ALA A 1 302 ? -22.146 -15.655 -22.616 1.00 48.86  ? 565  ALA A O   1 
ATOM   2136 C  CB  . ALA A 1 302 ? -24.014 -16.725 -25.023 1.00 48.58  ? 565  ALA A CB  1 
ATOM   2137 N  N   . GLU A 1 303 ? -23.207 -13.935 -23.618 1.00 51.14  ? 566  GLU A N   1 
ATOM   2138 C  CA  . GLU A 1 303 ? -22.120 -12.969 -23.334 1.00 50.19  ? 566  GLU A CA  1 
ATOM   2139 C  C   . GLU A 1 303 ? -21.999 -12.772 -21.827 1.00 47.32  ? 566  GLU A C   1 
ATOM   2140 O  O   . GLU A 1 303 ? -20.861 -12.583 -21.343 1.00 45.47  ? 566  GLU A O   1 
ATOM   2141 C  CB  . GLU A 1 303 ? -22.351 -11.662 -24.071 1.00 55.21  ? 566  GLU A CB  1 
ATOM   2142 C  CG  . GLU A 1 303 ? -21.961 -11.786 -25.532 1.00 66.34  ? 566  GLU A CG  1 
ATOM   2143 C  CD  . GLU A 1 303 ? -22.114 -10.536 -26.377 1.00 67.22  ? 566  GLU A CD  1 
ATOM   2144 O  OE1 . GLU A 1 303 ? -22.956 -9.707  -26.029 1.00 64.78  ? 566  GLU A OE1 1 
ATOM   2145 O  OE2 . GLU A 1 303 ? -21.378 -10.404 -27.383 1.00 81.36  ? 566  GLU A OE2 1 
ATOM   2146 N  N   . ALA A 1 304 ? -23.116 -12.868 -21.120 1.00 44.68  ? 567  ALA A N   1 
ATOM   2147 C  CA  . ALA A 1 304 ? -23.175 -12.666 -19.656 1.00 52.41  ? 567  ALA A CA  1 
ATOM   2148 C  C   . ALA A 1 304 ? -22.705 -13.932 -18.916 1.00 49.30  ? 567  ALA A C   1 
ATOM   2149 O  O   . ALA A 1 304 ? -22.074 -13.776 -17.873 1.00 55.79  ? 567  ALA A O   1 
ATOM   2150 C  CB  . ALA A 1 304 ? -24.567 -12.242 -19.229 1.00 49.56  ? 567  ALA A CB  1 
ATOM   2151 N  N   . ILE A 1 305 ? -23.025 -15.139 -19.394 1.00 48.95  ? 568  ILE A N   1 
ATOM   2152 C  CA  . ILE A 1 305 ? -22.466 -16.375 -18.784 1.00 47.17  ? 568  ILE A CA  1 
ATOM   2153 C  C   . ILE A 1 305 ? -20.944 -16.225 -18.867 1.00 48.56  ? 568  ILE A C   1 
ATOM   2154 O  O   . ILE A 1 305 ? -20.263 -16.297 -17.807 1.00 46.74  ? 568  ILE A O   1 
ATOM   2155 C  CB  . ILE A 1 305 ? -22.963 -17.661 -19.468 1.00 55.14  ? 568  ILE A CB  1 
ATOM   2156 C  CG1 . ILE A 1 305 ? -24.459 -17.908 -19.222 1.00 48.29  ? 568  ILE A CG1 1 
ATOM   2157 C  CG2 . ILE A 1 305 ? -22.087 -18.870 -19.078 1.00 47.92  ? 568  ILE A CG2 1 
ATOM   2158 C  CD1 . ILE A 1 305 ? -24.908 -17.662 -17.809 1.00 46.89  ? 568  ILE A CD1 1 
ATOM   2159 N  N   . PHE A 1 306 ? -20.419 -15.909 -20.050 1.00 43.65  ? 569  PHE A N   1 
ATOM   2160 C  CA  . PHE A 1 306 ? -18.946 -15.831 -20.241 1.00 48.72  ? 569  PHE A CA  1 
ATOM   2161 C  C   . PHE A 1 306 ? -18.384 -14.756 -19.305 1.00 59.79  ? 569  PHE A C   1 
ATOM   2162 O  O   . PHE A 1 306 ? -17.426 -15.067 -18.581 1.00 67.26  ? 569  PHE A O   1 
ATOM   2163 C  CB  . PHE A 1 306 ? -18.543 -15.601 -21.699 1.00 43.39  ? 569  PHE A CB  1 
ATOM   2164 C  CG  . PHE A 1 306 ? -18.451 -16.863 -22.517 1.00 45.64  ? 569  PHE A CG  1 
ATOM   2165 C  CD1 . PHE A 1 306 ? -17.427 -17.766 -22.300 1.00 51.13  ? 569  PHE A CD1 1 
ATOM   2166 C  CD2 . PHE A 1 306 ? -19.361 -17.137 -23.521 1.00 47.21  ? 569  PHE A CD2 1 
ATOM   2167 C  CE1 . PHE A 1 306 ? -17.346 -18.933 -23.040 1.00 52.09  ? 569  PHE A CE1 1 
ATOM   2168 C  CE2 . PHE A 1 306 ? -19.277 -18.301 -24.272 1.00 51.56  ? 569  PHE A CE2 1 
ATOM   2169 C  CZ  . PHE A 1 306 ? -18.280 -19.212 -24.013 1.00 51.01  ? 569  PHE A CZ  1 
ATOM   2170 N  N   . LYS A 1 307 ? -18.987 -13.558 -19.310 1.00 67.89  ? 570  LYS A N   1 
ATOM   2171 C  CA  . LYS A 1 307 ? -18.482 -12.325 -18.649 1.00 60.17  ? 570  LYS A CA  1 
ATOM   2172 C  C   . LYS A 1 307 ? -18.581 -12.503 -17.127 1.00 57.07  ? 570  LYS A C   1 
ATOM   2173 O  O   . LYS A 1 307 ? -17.590 -12.244 -16.443 1.00 51.18  ? 570  LYS A O   1 
ATOM   2174 C  CB  . LYS A 1 307 ? -19.290 -11.117 -19.146 1.00 75.81  ? 570  LYS A CB  1 
ATOM   2175 C  CG  . LYS A 1 307 ? -18.546 -9.792  -19.248 1.00 85.09  ? 570  LYS A CG  1 
ATOM   2176 C  CD  . LYS A 1 307 ? -19.426 -8.582  -18.925 1.00 97.08  ? 570  LYS A CD  1 
ATOM   2177 C  CE  . LYS A 1 307 ? -18.843 -7.258  -19.381 1.00 103.07 ? 570  LYS A CE  1 
ATOM   2178 N  NZ  . LYS A 1 307 ? -19.044 -7.043  -20.836 1.00 116.08 ? 570  LYS A NZ  1 
ATOM   2179 N  N   . LEU A 1 308 ? -19.717 -12.997 -16.627 1.00 53.12  ? 571  LEU A N   1 
ATOM   2180 C  CA  . LEU A 1 308 ? -20.127 -12.837 -15.204 1.00 57.72  ? 571  LEU A CA  1 
ATOM   2181 C  C   . LEU A 1 308 ? -19.937 -14.115 -14.375 1.00 60.76  ? 571  LEU A C   1 
ATOM   2182 O  O   . LEU A 1 308 ? -19.894 -13.995 -13.140 1.00 58.58  ? 571  LEU A O   1 
ATOM   2183 C  CB  . LEU A 1 308 ? -21.600 -12.419 -15.183 1.00 57.03  ? 571  LEU A CB  1 
ATOM   2184 C  CG  . LEU A 1 308 ? -21.943 -11.240 -16.098 1.00 57.99  ? 571  LEU A CG  1 
ATOM   2185 C  CD1 . LEU A 1 308 ? -23.413 -10.927 -16.006 1.00 57.54  ? 571  LEU A CD1 1 
ATOM   2186 C  CD2 . LEU A 1 308 ? -21.115 -10.006 -15.761 1.00 58.50  ? 571  LEU A CD2 1 
ATOM   2187 N  N   . THR A 1 309 ? -19.932 -15.294 -14.990 1.00 57.46  ? 572  THR A N   1 
ATOM   2188 C  CA  . THR A 1 309 ? -19.776 -16.583 -14.265 1.00 58.94  ? 572  THR A CA  1 
ATOM   2189 C  C   . THR A 1 309 ? -18.388 -17.162 -14.573 1.00 52.02  ? 572  THR A C   1 
ATOM   2190 O  O   . THR A 1 309 ? -17.717 -17.490 -13.622 1.00 67.44  ? 572  THR A O   1 
ATOM   2191 C  CB  . THR A 1 309 ? -20.996 -17.483 -14.498 1.00 62.89  ? 572  THR A CB  1 
ATOM   2192 O  OG1 . THR A 1 309 ? -21.019 -17.926 -15.852 1.00 60.04  ? 572  THR A OG1 1 
ATOM   2193 C  CG2 . THR A 1 309 ? -22.294 -16.764 -14.206 1.00 70.40  ? 572  THR A CG2 1 
ATOM   2194 N  N   . TYR A 1 310 ? -17.916 -17.148 -15.822 1.00 53.71  ? 573  TYR A N   1 
ATOM   2195 C  CA  . TYR A 1 310 ? -16.635 -17.789 -16.240 1.00 52.72  ? 573  TYR A CA  1 
ATOM   2196 C  C   . TYR A 1 310 ? -15.431 -16.856 -16.039 1.00 57.01  ? 573  TYR A C   1 
ATOM   2197 O  O   . TYR A 1 310 ? -14.441 -17.341 -15.440 1.00 61.18  ? 573  TYR A O   1 
ATOM   2198 C  CB  . TYR A 1 310 ? -16.681 -18.265 -17.701 1.00 47.22  ? 573  TYR A CB  1 
ATOM   2199 C  CG  . TYR A 1 310 ? -17.721 -19.314 -17.997 1.00 43.25  ? 573  TYR A CG  1 
ATOM   2200 C  CD1 . TYR A 1 310 ? -18.487 -19.906 -16.997 1.00 39.05  ? 573  TYR A CD1 1 
ATOM   2201 C  CD2 . TYR A 1 310 ? -17.951 -19.718 -19.296 1.00 41.20  ? 573  TYR A CD2 1 
ATOM   2202 C  CE1 . TYR A 1 310 ? -19.442 -20.864 -17.296 1.00 38.03  ? 573  TYR A CE1 1 
ATOM   2203 C  CE2 . TYR A 1 310 ? -18.904 -20.676 -19.603 1.00 38.56  ? 573  TYR A CE2 1 
ATOM   2204 C  CZ  . TYR A 1 310 ? -19.645 -21.257 -18.607 1.00 36.83  ? 573  TYR A CZ  1 
ATOM   2205 O  OH  . TYR A 1 310 ? -20.591 -22.190 -18.938 1.00 44.70  ? 573  TYR A OH  1 
ATOM   2206 N  N   . GLN A 1 311 ? -15.466 -15.615 -16.557 1.00 51.50  ? 574  GLN A N   1 
ATOM   2207 C  CA  . GLN A 1 311 ? -14.303 -14.687 -16.541 1.00 48.39  ? 574  GLN A CA  1 
ATOM   2208 C  C   . GLN A 1 311 ? -14.241 -13.920 -15.216 1.00 48.83  ? 574  GLN A C   1 
ATOM   2209 O  O   . GLN A 1 311 ? -13.270 -13.150 -15.040 1.00 50.05  ? 574  GLN A O   1 
ATOM   2210 C  CB  . GLN A 1 311 ? -14.335 -13.759 -17.745 1.00 47.91  ? 574  GLN A CB  1 
ATOM   2211 C  CG  . GLN A 1 311 ? -14.303 -14.545 -19.039 1.00 49.79  ? 574  GLN A CG  1 
ATOM   2212 C  CD  . GLN A 1 311 ? -14.289 -13.666 -20.255 1.00 50.62  ? 574  GLN A CD  1 
ATOM   2213 O  OE1 . GLN A 1 311 ? -14.204 -12.462 -20.154 1.00 59.86  ? 574  GLN A OE1 1 
ATOM   2214 N  NE2 . GLN A 1 311 ? -14.335 -14.276 -21.422 1.00 58.63  ? 574  GLN A NE2 1 
ATOM   2215 N  N   . ASN A 1 312 ? -15.232 -14.133 -14.346 1.00 48.12  ? 575  ASN A N   1 
ATOM   2216 C  CA  . ASN A 1 312 ? -15.335 -13.606 -12.957 1.00 51.94  ? 575  ASN A CA  1 
ATOM   2217 C  C   . ASN A 1 312 ? -16.181 -14.612 -12.189 1.00 55.27  ? 575  ASN A C   1 
ATOM   2218 O  O   . ASN A 1 312 ? -17.330 -14.814 -12.567 1.00 85.62  ? 575  ASN A O   1 
ATOM   2219 C  CB  . ASN A 1 312 ? -16.017 -12.233 -12.862 1.00 50.49  ? 575  ASN A CB  1 
ATOM   2220 C  CG  . ASN A 1 312 ? -15.233 -11.124 -13.528 1.00 52.23  ? 575  ASN A CG  1 
ATOM   2221 O  OD1 . ASN A 1 312 ? -14.332 -10.563 -12.927 1.00 61.09  ? 575  ASN A OD1 1 
ATOM   2222 N  ND2 . ASN A 1 312 ? -15.548 -10.810 -14.773 1.00 57.58  ? 575  ASN A ND2 1 
ATOM   2223 N  N   . LYS A 1 313 ? -15.613 -15.294 -11.214 1.00 60.23  ? 576  LYS A N   1 
ATOM   2224 C  CA  . LYS A 1 313 ? -16.327 -16.368 -10.493 1.00 62.53  ? 576  LYS A CA  1 
ATOM   2225 C  C   . LYS A 1 313 ? -16.428 -15.939 -9.039  1.00 58.65  ? 576  LYS A C   1 
ATOM   2226 O  O   . LYS A 1 313 ? -15.616 -15.125 -8.606  1.00 60.78  ? 576  LYS A O   1 
ATOM   2227 C  CB  . LYS A 1 313 ? -15.587 -17.710 -10.582 1.00 67.56  ? 576  LYS A CB  1 
ATOM   2228 C  CG  . LYS A 1 313 ? -14.886 -18.010 -11.897 1.00 69.30  ? 576  LYS A CG  1 
ATOM   2229 C  CD  . LYS A 1 313 ? -14.262 -19.401 -11.911 1.00 68.86  ? 576  LYS A CD  1 
ATOM   2230 C  CE  . LYS A 1 313 ? -13.506 -19.727 -13.186 1.00 63.18  ? 576  LYS A CE  1 
ATOM   2231 N  NZ  . LYS A 1 313 ? -12.513 -18.688 -13.532 1.00 62.14  ? 576  LYS A NZ  1 
ATOM   2232 N  N   . VAL A 1 314 ? -17.380 -16.505 -8.322  1.00 58.53  ? 577  VAL A N   1 
ATOM   2233 C  CA  . VAL A 1 314 ? -17.493 -16.353 -6.855  1.00 54.77  ? 577  VAL A CA  1 
ATOM   2234 C  C   . VAL A 1 314 ? -17.750 -17.761 -6.385  1.00 59.17  ? 577  VAL A C   1 
ATOM   2235 O  O   . VAL A 1 314 ? -18.543 -18.454 -7.066  1.00 55.76  ? 577  VAL A O   1 
ATOM   2236 C  CB  . VAL A 1 314 ? -18.621 -15.391 -6.444  1.00 59.00  ? 577  VAL A CB  1 
ATOM   2237 C  CG1 . VAL A 1 314 ? -19.044 -15.590 -4.988  1.00 61.74  ? 577  VAL A CG1 1 
ATOM   2238 C  CG2 . VAL A 1 314 ? -18.230 -13.946 -6.715  1.00 55.66  ? 577  VAL A CG2 1 
ATOM   2239 N  N   . VAL A 1 315 ? -17.035 -18.173 -5.341  1.00 57.10  ? 578  VAL A N   1 
ATOM   2240 C  CA  . VAL A 1 315 ? -17.008 -19.596 -4.928  1.00 59.13  ? 578  VAL A CA  1 
ATOM   2241 C  C   . VAL A 1 315 ? -17.069 -19.623 -3.405  1.00 61.40  ? 578  VAL A C   1 
ATOM   2242 O  O   . VAL A 1 315 ? -16.365 -18.830 -2.771  1.00 60.10  ? 578  VAL A O   1 
ATOM   2243 C  CB  . VAL A 1 315 ? -15.750 -20.291 -5.487  1.00 58.46  ? 578  VAL A CB  1 
ATOM   2244 C  CG1 . VAL A 1 315 ? -15.821 -21.801 -5.340  1.00 63.06  ? 578  VAL A CG1 1 
ATOM   2245 C  CG2 . VAL A 1 315 ? -15.491 -19.915 -6.936  1.00 55.55  ? 578  VAL A CG2 1 
ATOM   2246 N  N   . ARG A 1 316 ? -17.871 -20.522 -2.863  1.00 64.36  ? 579  ARG A N   1 
ATOM   2247 C  CA  . ARG A 1 316 ? -17.912 -20.795 -1.412  1.00 83.17  ? 579  ARG A CA  1 
ATOM   2248 C  C   . ARG A 1 316 ? -17.217 -22.140 -1.139  1.00 91.76  ? 579  ARG A C   1 
ATOM   2249 O  O   . ARG A 1 316 ? -17.780 -23.200 -1.493  1.00 87.31  ? 579  ARG A O   1 
ATOM   2250 C  CB  . ARG A 1 316 ? -19.365 -20.741 -0.948  1.00 77.60  ? 579  ARG A CB  1 
ATOM   2251 C  CG  . ARG A 1 316 ? -20.309 -21.587 -1.779  1.00 78.80  ? 579  ARG A CG  1 
ATOM   2252 C  CD  . ARG A 1 316 ? -21.690 -21.470 -1.210  1.00 86.58  ? 579  ARG A CD  1 
ATOM   2253 N  NE  . ARG A 1 316 ? -22.064 -20.075 -1.149  1.00 88.30  ? 579  ARG A NE  1 
ATOM   2254 C  CZ  . ARG A 1 316 ? -23.271 -19.648 -0.843  1.00 85.04  ? 579  ARG A CZ  1 
ATOM   2255 N  NH1 . ARG A 1 316 ? -23.503 -18.348 -0.810  1.00 87.25  ? 579  ARG A NH1 1 
ATOM   2256 N  NH2 . ARG A 1 316 ? -24.230 -20.513 -0.561  1.00 88.20  ? 579  ARG A NH2 1 
ATOM   2257 N  N   . VAL A 1 317 ? -16.041 -22.092 -0.499  0.50 93.82  ? 580  VAL A N   1 
ATOM   2258 C  CA  . VAL A 1 317 ? -15.243 -23.277 -0.058  0.50 97.01  ? 580  VAL A CA  1 
ATOM   2259 C  C   . VAL A 1 317 ? -15.463 -23.486 1.446   0.50 101.60 ? 580  VAL A C   1 
ATOM   2260 O  O   . VAL A 1 317 ? -15.475 -22.480 2.180   0.50 99.78  ? 580  VAL A O   1 
ATOM   2261 C  CB  . VAL A 1 317 ? -13.748 -23.094 -0.379  0.50 97.03  ? 580  VAL A CB  1 
ATOM   2262 C  CG1 . VAL A 1 317 ? -12.963 -24.370 -0.126  0.50 98.21  ? 580  VAL A CG1 1 
ATOM   2263 C  CG2 . VAL A 1 317 ? -13.528 -22.606 -1.802  0.50 98.39  ? 580  VAL A CG2 1 
ATOM   2264 N  N   . GLN A 1 318 ? -15.612 -24.743 1.881   0.50 108.35 ? 581  GLN A N   1 
ATOM   2265 C  CA  . GLN A 1 318 ? -15.912 -25.121 3.291   0.50 111.27 ? 581  GLN A CA  1 
ATOM   2266 C  C   . GLN A 1 318 ? -14.619 -25.530 4.008   0.50 114.61 ? 581  GLN A C   1 
ATOM   2267 O  O   . GLN A 1 318 ? -14.317 -26.739 4.026   0.50 115.74 ? 581  GLN A O   1 
ATOM   2268 C  CB  . GLN A 1 318 ? -16.922 -26.270 3.334   0.50 110.99 ? 581  GLN A CB  1 
ATOM   2269 C  CG  . GLN A 1 318 ? -17.679 -26.356 4.652   0.50 113.90 ? 581  GLN A CG  1 
ATOM   2270 C  CD  . GLN A 1 318 ? -18.459 -27.640 4.802   0.50 115.82 ? 581  GLN A CD  1 
ATOM   2271 O  OE1 . GLN A 1 318 ? -17.952 -28.730 4.547   0.50 120.53 ? 581  GLN A OE1 1 
ATOM   2272 N  NE2 . GLN A 1 318 ? -19.711 -27.520 5.212   0.50 115.26 ? 581  GLN A NE2 1 
ATOM   2273 N  N   . ARG A 1 319 ? -13.909 -24.560 4.595   0.50 117.32 ? 582  ARG A N   1 
ATOM   2274 C  CA  . ARG A 1 319 ? -12.602 -24.753 5.285   0.50 123.65 ? 582  ARG A CA  1 
ATOM   2275 C  C   . ARG A 1 319 ? -12.837 -25.281 6.698   0.50 132.92 ? 582  ARG A C   1 
ATOM   2276 O  O   . ARG A 1 319 ? -13.515 -24.638 7.497   0.50 134.02 ? 582  ARG A O   1 
ATOM   2277 C  CB  . ARG A 1 319 ? -11.822 -23.434 5.305   0.50 122.46 ? 582  ARG A CB  1 
ATOM   2278 C  CG  . ARG A 1 319 ? -10.475 -23.511 6.010   0.50 121.18 ? 582  ARG A CG  1 
ATOM   2279 C  CD  . ARG A 1 319 ? -9.461  -22.542 5.428   0.50 122.50 ? 582  ARG A CD  1 
ATOM   2280 N  NE  . ARG A 1 319 ? -9.887  -21.152 5.515   0.50 124.93 ? 582  ARG A NE  1 
ATOM   2281 C  CZ  . ARG A 1 319 ? -9.417  -20.270 6.391   0.50 128.62 ? 582  ARG A CZ  1 
ATOM   2282 N  NH1 . ARG A 1 319 ? -8.494  -20.633 7.266   0.50 131.99 ? 582  ARG A NH1 1 
ATOM   2283 N  NH2 . ARG A 1 319 ? -9.863  -19.026 6.386   0.50 129.49 ? 582  ARG A NH2 1 
ATOM   2284 N  N   . PRO A 1 320 ? -12.281 -26.466 7.046   0.50 145.45 ? 583  PRO A N   1 
ATOM   2285 C  CA  . PRO A 1 320 ? -12.473 -27.069 8.369   0.50 145.90 ? 583  PRO A CA  1 
ATOM   2286 C  C   . PRO A 1 320 ? -11.979 -26.203 9.541   0.50 142.31 ? 583  PRO A C   1 
ATOM   2287 O  O   . PRO A 1 320 ? -12.542 -26.307 10.618  0.50 140.30 ? 583  PRO A O   1 
ATOM   2288 C  CB  . PRO A 1 320 ? -11.647 -28.366 8.308   0.50 147.64 ? 583  PRO A CB  1 
ATOM   2289 C  CG  . PRO A 1 320 ? -11.517 -28.667 6.828   0.50 147.87 ? 583  PRO A CG  1 
ATOM   2290 C  CD  . PRO A 1 320 ? -11.460 -27.308 6.162   0.50 147.24 ? 583  PRO A CD  1 
ATOM   2291 N  N   . THR A 1 321 ? -10.944 -25.388 9.309   0.50 137.99 ? 584  THR A N   1 
ATOM   2292 C  CA  . THR A 1 321 ? -10.322 -24.487 10.318  0.50 136.50 ? 584  THR A CA  1 
ATOM   2293 C  C   . THR A 1 321 ? -11.398 -23.581 10.931  0.50 134.12 ? 584  THR A C   1 
ATOM   2294 O  O   . THR A 1 321 ? -11.824 -23.883 12.066  0.50 130.00 ? 584  THR A O   1 
ATOM   2295 C  CB  . THR A 1 321 ? -9.193  -23.658 9.691   0.50 135.69 ? 584  THR A CB  1 
ATOM   2296 O  OG1 . THR A 1 321 ? -9.791  -22.672 8.849   0.50 139.73 ? 584  THR A OG1 1 
ATOM   2297 C  CG2 . THR A 1 321 ? -8.219  -24.493 8.889   0.50 135.28 ? 584  THR A CG2 1 
ATOM   2298 N  N   . THR A 1 325 ? -15.483 -25.251 11.492  1.00 126.27 ? 588  THR A N   1 
ATOM   2299 C  CA  . THR A 1 325 ? -15.304 -25.000 10.036  1.00 130.14 ? 588  THR A CA  1 
ATOM   2300 C  C   . THR A 1 325 ? -15.892 -23.639 9.661   1.00 128.80 ? 588  THR A C   1 
ATOM   2301 O  O   . THR A 1 325 ? -16.732 -23.124 10.419  1.00 125.95 ? 588  THR A O   1 
ATOM   2302 C  CB  . THR A 1 325 ? -15.950 -26.097 9.183   1.00 135.21 ? 588  THR A CB  1 
ATOM   2303 O  OG1 . THR A 1 325 ? -15.521 -25.925 7.833   1.00 135.32 ? 588  THR A OG1 1 
ATOM   2304 C  CG2 . THR A 1 325 ? -17.462 -26.078 9.240   1.00 129.48 ? 588  THR A CG2 1 
ATOM   2305 N  N   . VAL A 1 326 ? -15.466 -23.092 8.524   1.00 123.25 ? 589  VAL A N   1 
ATOM   2306 C  CA  . VAL A 1 326 ? -15.991 -21.779 8.055   1.00 121.60 ? 589  VAL A CA  1 
ATOM   2307 C  C   . VAL A 1 326 ? -16.353 -21.889 6.574   1.00 121.14 ? 589  VAL A C   1 
ATOM   2308 O  O   . VAL A 1 326 ? -16.063 -22.939 5.973   1.00 120.72 ? 589  VAL A O   1 
ATOM   2309 C  CB  . VAL A 1 326 ? -14.972 -20.650 8.282   1.00 115.05 ? 589  VAL A CB  1 
ATOM   2310 C  CG1 . VAL A 1 326 ? -14.636 -20.478 9.753   1.00 116.24 ? 589  VAL A CG1 1 
ATOM   2311 C  CG2 . VAL A 1 326 ? -13.712 -20.850 7.457   1.00 111.10 ? 589  VAL A CG2 1 
ATOM   2312 N  N   . MET A 1 327 ? -16.985 -20.851 6.024   1.00 110.17 ? 590  MET A N   1 
ATOM   2313 C  CA  . MET A 1 327 ? -17.306 -20.829 4.579   1.00 98.07  ? 590  MET A CA  1 
ATOM   2314 C  C   . MET A 1 327 ? -16.620 -19.609 3.969   1.00 91.40  ? 590  MET A C   1 
ATOM   2315 O  O   . MET A 1 327 ? -17.098 -18.494 4.189   1.00 89.46  ? 590  MET A O   1 
ATOM   2316 C  CB  . MET A 1 327 ? -18.813 -20.722 4.359   1.00 98.55  ? 590  MET A CB  1 
ATOM   2317 C  CG  . MET A 1 327 ? -19.209 -20.798 2.899   1.00 103.26 ? 590  MET A CG  1 
ATOM   2318 S  SD  . MET A 1 327 ? -18.820 -22.403 2.163   1.00 106.52 ? 590  MET A SD  1 
ATOM   2319 C  CE  . MET A 1 327 ? -20.021 -23.446 2.985   1.00 98.87  ? 590  MET A CE  1 
ATOM   2320 N  N   . ASP A 1 328 ? -15.520 -19.828 3.257   1.00 90.91  ? 591  ASP A N   1 
ATOM   2321 C  CA  . ASP A 1 328 ? -14.783 -18.701 2.638   1.00 98.72  ? 591  ASP A CA  1 
ATOM   2322 C  C   . ASP A 1 328 ? -15.484 -18.284 1.347   1.00 95.24  ? 591  ASP A C   1 
ATOM   2323 O  O   . ASP A 1 328 ? -15.922 -19.174 0.602   1.00 84.92  ? 591  ASP A O   1 
ATOM   2324 C  CB  . ASP A 1 328 ? -13.322 -19.059 2.365   1.00 105.56 ? 591  ASP A CB  1 
ATOM   2325 C  CG  . ASP A 1 328 ? -12.501 -19.260 3.627   1.00 114.25 ? 591  ASP A CG  1 
ATOM   2326 O  OD1 . ASP A 1 328 ? -12.449 -18.323 4.445   1.00 103.13 ? 591  ASP A OD1 1 
ATOM   2327 O  OD2 . ASP A 1 328 ? -11.927 -20.355 3.782   1.00 101.01 ? 591  ASP A OD2 1 
ATOM   2328 N  N   . ILE A 1 329 ? -15.614 -16.980 1.123   1.00 82.39  ? 592  ILE A N   1 
ATOM   2329 C  CA  . ILE A 1 329 ? -16.176 -16.499 -0.167  1.00 71.70  ? 592  ILE A CA  1 
ATOM   2330 C  C   . ILE A 1 329 ? -14.977 -15.982 -0.947  1.00 68.94  ? 592  ILE A C   1 
ATOM   2331 O  O   . ILE A 1 329 ? -14.474 -14.901 -0.618  1.00 72.04  ? 592  ILE A O   1 
ATOM   2332 C  CB  . ILE A 1 329 ? -17.295 -15.459 0.022   1.00 72.83  ? 592  ILE A CB  1 
ATOM   2333 C  CG1 . ILE A 1 329 ? -18.472 -16.047 0.803   1.00 64.54  ? 592  ILE A CG1 1 
ATOM   2334 C  CG2 . ILE A 1 329 ? -17.736 -14.894 -1.317  1.00 65.71  ? 592  ILE A CG2 1 
ATOM   2335 C  CD1 . ILE A 1 329 ? -19.010 -17.328 0.217   1.00 62.35  ? 592  ILE A CD1 1 
ATOM   2336 N  N   . ILE A 1 330 ? -14.538 -16.754 -1.924  0.50 70.74  ? 593  ILE A N   1 
ATOM   2337 C  CA  . ILE A 1 330 ? -13.312 -16.437 -2.712  0.50 71.26  ? 593  ILE A CA  1 
ATOM   2338 C  C   . ILE A 1 330 ? -13.727 -16.184 -4.165  0.50 67.81  ? 593  ILE A C   1 
ATOM   2339 O  O   . ILE A 1 330 ? -14.822 -16.641 -4.552  0.50 69.00  ? 593  ILE A O   1 
ATOM   2340 C  CB  . ILE A 1 330 ? -12.294 -17.587 -2.579  0.50 72.02  ? 593  ILE A CB  1 
ATOM   2341 C  CG1 . ILE A 1 330 ? -12.800 -18.869 -3.245  0.50 72.30  ? 593  ILE A CG1 1 
ATOM   2342 C  CG2 . ILE A 1 330 ? -11.947 -17.817 -1.116  0.50 71.70  ? 593  ILE A CG2 1 
ATOM   2343 C  CD1 . ILE A 1 330 ? -11.848 -20.039 -3.137  0.50 72.42  ? 593  ILE A CD1 1 
ATOM   2344 N  N   . SER A 1 331 ? -12.886 -15.477 -4.923  0.50 63.27  ? 594  SER A N   1 
ATOM   2345 C  CA  . SER A 1 331 ? -13.119 -15.109 -6.342  0.50 63.42  ? 594  SER A CA  1 
ATOM   2346 C  C   . SER A 1 331 ? -11.823 -15.287 -7.137  0.50 63.55  ? 594  SER A C   1 
ATOM   2347 O  O   . SER A 1 331 ? -10.754 -15.374 -6.506  0.50 65.10  ? 594  SER A O   1 
ATOM   2348 C  CB  . SER A 1 331 ? -13.625 -13.696 -6.451  0.50 62.22  ? 594  SER A CB  1 
ATOM   2349 O  OG  . SER A 1 331 ? -12.544 -12.776 -6.413  0.50 61.68  ? 594  SER A OG  1 
ATOM   2350 N  N   . ARG A 1 332 ? -11.929 -15.323 -8.469  0.50 61.84  ? 595  ARG A N   1 
ATOM   2351 C  CA  . ARG A 1 332 ? -10.782 -15.349 -9.413  0.50 62.91  ? 595  ARG A CA  1 
ATOM   2352 C  C   . ARG A 1 332 ? -11.320 -15.245 -10.842 0.50 63.81  ? 595  ARG A C   1 
ATOM   2353 O  O   . ARG A 1 332 ? -12.523 -15.525 -11.034 0.50 66.09  ? 595  ARG A O   1 
ATOM   2354 C  CB  . ARG A 1 332 ? -9.965  -16.633 -9.246  0.50 67.00  ? 595  ARG A CB  1 
ATOM   2355 C  CG  . ARG A 1 332 ? -10.463 -17.800 -10.085 0.50 67.49  ? 595  ARG A CG  1 
ATOM   2356 C  CD  . ARG A 1 332 ? -9.523  -18.990 -10.030 0.50 69.98  ? 595  ARG A CD  1 
ATOM   2357 N  NE  . ARG A 1 332 ? -8.167  -18.682 -10.475 0.50 69.06  ? 595  ARG A NE  1 
ATOM   2358 C  CZ  . ARG A 1 332 ? -7.072  -18.843 -9.734  0.50 69.28  ? 595  ARG A CZ  1 
ATOM   2359 N  NH1 . ARG A 1 332 ? -7.166  -19.313 -8.501  0.50 70.87  ? 595  ARG A NH1 1 
ATOM   2360 N  NH2 . ARG A 1 332 ? -5.886  -18.545 -10.233 0.50 65.90  ? 595  ARG A NH2 1 
ATOM   2361 N  N   . ARG A 1 333 ? -10.455 -14.885 -11.796 1.00 59.38  ? 596  ARG A N   1 
ATOM   2362 C  CA  . ARG A 1 333 ? -10.849 -14.612 -13.200 1.00 63.76  ? 596  ARG A CA  1 
ATOM   2363 C  C   . ARG A 1 333 ? -10.597 -15.808 -14.131 1.00 65.47  ? 596  ARG A C   1 
ATOM   2364 O  O   . ARG A 1 333 ? -11.348 -15.946 -15.102 1.00 71.67  ? 596  ARG A O   1 
ATOM   2365 C  CB  . ARG A 1 333 ? -10.097 -13.355 -13.630 1.00 64.21  ? 596  ARG A CB  1 
ATOM   2366 C  CG  . ARG A 1 333 ? -10.424 -12.160 -12.732 1.00 69.88  ? 596  ARG A CG  1 
ATOM   2367 C  CD  . ARG A 1 333 ? -10.427 -10.834 -13.485 1.00 78.82  ? 596  ARG A CD  1 
ATOM   2368 N  NE  . ARG A 1 333 ? -11.186 -10.956 -14.735 1.00 84.95  ? 596  ARG A NE  1 
ATOM   2369 C  CZ  . ARG A 1 333 ? -10.861 -10.405 -15.908 1.00 90.73  ? 596  ARG A CZ  1 
ATOM   2370 N  NH1 . ARG A 1 333 ? -9.779  -9.647  -16.029 1.00 93.82  ? 596  ARG A NH1 1 
ATOM   2371 N  NH2 . ARG A 1 333 ? -11.621 -10.633 -16.968 1.00 86.84  ? 596  ARG A NH2 1 
ATOM   2372 N  N   . ASP A 1 334 ? -9.614  -16.654 -13.840 1.00 60.75  ? 597  ASP A N   1 
ATOM   2373 C  CA  . ASP A 1 334 ? -9.108  -17.695 -14.772 1.00 54.55  ? 597  ASP A CA  1 
ATOM   2374 C  C   . ASP A 1 334 ? -9.458  -19.077 -14.218 1.00 55.87  ? 597  ASP A C   1 
ATOM   2375 O  O   . ASP A 1 334 ? -10.210 -19.130 -13.212 1.00 49.84  ? 597  ASP A O   1 
ATOM   2376 C  CB  . ASP A 1 334 ? -7.606  -17.514 -14.994 1.00 58.06  ? 597  ASP A CB  1 
ATOM   2377 C  CG  . ASP A 1 334 ? -6.842  -17.427 -13.685 1.00 63.00  ? 597  ASP A CG  1 
ATOM   2378 O  OD1 . ASP A 1 334 ? -7.011  -18.331 -12.856 1.00 64.58  ? 597  ASP A OD1 1 
ATOM   2379 O  OD2 . ASP A 1 334 ? -6.138  -16.422 -13.473 1.00 90.21  ? 597  ASP A OD2 1 
ATOM   2380 N  N   . GLN A 1 335 ? -8.985  -20.138 -14.884 1.00 53.73  ? 598  GLN A N   1 
ATOM   2381 C  CA  . GLN A 1 335 ? -9.280  -21.547 -14.503 1.00 52.55  ? 598  GLN A CA  1 
ATOM   2382 C  C   . GLN A 1 335 ? -10.660 -21.946 -15.033 1.00 54.30  ? 598  GLN A C   1 
ATOM   2383 O  O   . GLN A 1 335 ? -11.491 -21.057 -15.240 1.00 63.22  ? 598  GLN A O   1 
ATOM   2384 C  CB  . GLN A 1 335 ? -9.139  -21.785 -12.998 1.00 54.99  ? 598  GLN A CB  1 
ATOM   2385 C  CG  . GLN A 1 335 ? -7.702  -21.713 -12.504 1.00 59.01  ? 598  GLN A CG  1 
ATOM   2386 C  CD  . GLN A 1 335 ? -7.544  -22.270 -11.112 1.00 59.96  ? 598  GLN A CD  1 
ATOM   2387 O  OE1 . GLN A 1 335 ? -8.515  -22.618 -10.448 1.00 69.03  ? 598  GLN A OE1 1 
ATOM   2388 N  NE2 . GLN A 1 335 ? -6.306  -22.364 -10.657 1.00 55.75  ? 598  GLN A NE2 1 
ATOM   2389 N  N   . ARG A 1 336 ? -10.872 -23.240 -15.261 1.00 49.72  ? 599  ARG A N   1 
ATOM   2390 C  CA  . ARG A 1 336 ? -12.193 -23.727 -15.716 1.00 51.39  ? 599  ARG A CA  1 
ATOM   2391 C  C   . ARG A 1 336 ? -13.101 -23.950 -14.517 1.00 58.27  ? 599  ARG A C   1 
ATOM   2392 O  O   . ARG A 1 336 ? -12.640 -24.519 -13.521 1.00 55.59  ? 599  ARG A O   1 
ATOM   2393 C  CB  . ARG A 1 336 ? -12.110 -25.055 -16.465 1.00 51.25  ? 599  ARG A CB  1 
ATOM   2394 C  CG  . ARG A 1 336 ? -13.462 -25.615 -16.879 1.00 46.78  ? 599  ARG A CG  1 
ATOM   2395 C  CD  . ARG A 1 336 ? -13.991 -24.889 -18.095 1.00 45.87  ? 599  ARG A CD  1 
ATOM   2396 N  NE  . ARG A 1 336 ? -13.187 -25.198 -19.266 1.00 40.95  ? 599  ARG A NE  1 
ATOM   2397 C  CZ  . ARG A 1 336 ? -12.919 -24.339 -20.236 1.00 42.42  ? 599  ARG A CZ  1 
ATOM   2398 N  NH1 . ARG A 1 336 ? -13.384 -23.105 -20.170 1.00 42.04  ? 599  ARG A NH1 1 
ATOM   2399 N  NH2 . ARG A 1 336 ? -12.182 -24.712 -21.265 1.00 39.95  ? 599  ARG A NH2 1 
ATOM   2400 N  N   . GLY A 1 337 ? -14.350 -23.521 -14.643 1.00 62.20  ? 600  GLY A N   1 
ATOM   2401 C  CA  . GLY A 1 337 ? -15.350 -23.710 -13.584 1.00 70.21  ? 600  GLY A CA  1 
ATOM   2402 C  C   . GLY A 1 337 ? -16.718 -23.520 -14.201 1.00 79.19  ? 600  GLY A C   1 
ATOM   2403 O  O   . GLY A 1 337 ? -17.163 -22.366 -14.297 1.00 88.55  ? 600  GLY A O   1 
ATOM   2404 N  N   . SER A 1 338 ? -17.334 -24.604 -14.656 1.00 74.22  ? 601  SER A N   1 
ATOM   2405 C  CA  . SER A 1 338 ? -18.640 -24.512 -15.342 1.00 67.50  ? 601  SER A CA  1 
ATOM   2406 C  C   . SER A 1 338 ? -19.342 -25.853 -15.200 1.00 69.31  ? 601  SER A C   1 
ATOM   2407 O  O   . SER A 1 338 ? -18.832 -26.706 -14.463 1.00 63.60  ? 601  SER A O   1 
ATOM   2408 C  CB  . SER A 1 338 ? -18.445 -24.179 -16.789 1.00 76.66  ? 601  SER A CB  1 
ATOM   2409 O  OG  . SER A 1 338 ? -17.217 -23.505 -17.005 1.00 72.25  ? 601  SER A OG  1 
ATOM   2410 N  N   . GLY A 1 339 ? -20.472 -26.018 -15.882 1.00 78.57  ? 602  GLY A N   1 
ATOM   2411 C  CA  . GLY A 1 339 ? -21.146 -27.325 -15.889 1.00 76.22  ? 602  GLY A CA  1 
ATOM   2412 C  C   . GLY A 1 339 ? -20.268 -28.353 -16.564 1.00 68.84  ? 602  GLY A C   1 
ATOM   2413 O  O   . GLY A 1 339 ? -19.506 -27.971 -17.460 1.00 59.82  ? 602  GLY A O   1 
ATOM   2414 N  N   . GLN A 1 340 ? -20.378 -29.609 -16.146 1.00 62.95  ? 603  GLN A N   1 
ATOM   2415 C  CA  . GLN A 1 340 ? -19.501 -30.666 -16.700 1.00 70.34  ? 603  GLN A CA  1 
ATOM   2416 C  C   . GLN A 1 340 ? -19.666 -30.740 -18.216 1.00 60.90  ? 603  GLN A C   1 
ATOM   2417 O  O   . GLN A 1 340 ? -18.654 -30.910 -18.893 1.00 56.73  ? 603  GLN A O   1 
ATOM   2418 C  CB  . GLN A 1 340 ? -19.820 -32.015 -16.053 1.00 81.43  ? 603  GLN A CB  1 
ATOM   2419 C  CG  . GLN A 1 340 ? -21.225 -32.529 -16.325 1.00 96.29  ? 603  GLN A CG  1 
ATOM   2420 C  CD  . GLN A 1 340 ? -21.297 -34.031 -16.191 1.00 114.43 ? 603  GLN A CD  1 
ATOM   2421 O  OE1 . GLN A 1 340 ? -20.286 -34.728 -16.247 1.00 111.95 ? 603  GLN A OE1 1 
ATOM   2422 N  NE2 . GLN A 1 340 ? -22.504 -34.545 -16.023 1.00 121.07 ? 603  GLN A NE2 1 
ATOM   2423 N  N   . VAL A 1 341 ? -20.892 -30.615 -18.721 1.00 55.03  ? 604  VAL A N   1 
ATOM   2424 C  CA  . VAL A 1 341 ? -21.112 -30.808 -20.184 1.00 50.35  ? 604  VAL A CA  1 
ATOM   2425 C  C   . VAL A 1 341 ? -20.587 -29.596 -20.953 1.00 49.82  ? 604  VAL A C   1 
ATOM   2426 O  O   . VAL A 1 341 ? -19.994 -29.803 -22.011 1.00 46.93  ? 604  VAL A O   1 
ATOM   2427 C  CB  . VAL A 1 341 ? -22.588 -31.091 -20.502 1.00 50.07  ? 604  VAL A CB  1 
ATOM   2428 C  CG1 . VAL A 1 341 ? -22.820 -31.191 -21.998 1.00 49.98  ? 604  VAL A CG1 1 
ATOM   2429 C  CG2 . VAL A 1 341 ? -23.084 -32.341 -19.795 1.00 51.60  ? 604  VAL A CG2 1 
ATOM   2430 N  N   . VAL A 1 342 ? -20.767 -28.388 -20.427 1.00 44.81  ? 605  VAL A N   1 
ATOM   2431 C  CA  . VAL A 1 342 ? -20.185 -27.231 -21.161 1.00 44.60  ? 605  VAL A CA  1 
ATOM   2432 C  C   . VAL A 1 342 ? -18.658 -27.272 -21.019 1.00 40.73  ? 605  VAL A C   1 
ATOM   2433 O  O   . VAL A 1 342 ? -17.957 -26.916 -21.967 1.00 41.43  ? 605  VAL A O   1 
ATOM   2434 C  CB  . VAL A 1 342 ? -20.824 -25.922 -20.675 1.00 47.47  ? 605  VAL A CB  1 
ATOM   2435 C  CG1 . VAL A 1 342 ? -20.051 -24.691 -21.102 1.00 48.66  ? 605  VAL A CG1 1 
ATOM   2436 C  CG2 . VAL A 1 342 ? -22.269 -25.846 -21.139 1.00 52.20  ? 605  VAL A CG2 1 
ATOM   2437 N  N   . THR A 1 343 ? -18.141 -27.644 -19.852 1.00 41.24  ? 606  THR A N   1 
ATOM   2438 C  CA  . THR A 1 343 ? -16.682 -27.856 -19.623 1.00 42.76  ? 606  THR A CA  1 
ATOM   2439 C  C   . THR A 1 343 ? -16.110 -28.833 -20.670 1.00 34.30  ? 606  THR A C   1 
ATOM   2440 O  O   . THR A 1 343 ? -15.105 -28.522 -21.274 1.00 37.93  ? 606  THR A O   1 
ATOM   2441 C  CB  . THR A 1 343 ? -16.455 -28.308 -18.178 1.00 44.70  ? 606  THR A CB  1 
ATOM   2442 O  OG1 . THR A 1 343 ? -16.832 -27.208 -17.350 1.00 44.88  ? 606  THR A OG1 1 
ATOM   2443 C  CG2 . THR A 1 343 ? -15.019 -28.682 -17.909 1.00 43.11  ? 606  THR A CG2 1 
ATOM   2444 N  N   . TYR A 1 344 ? -16.779 -29.953 -20.938 1.00 33.16  ? 607  TYR A N   1 
ATOM   2445 C  CA  . TYR A 1 344 ? -16.336 -30.917 -21.953 1.00 33.65  ? 607  TYR A CA  1 
ATOM   2446 C  C   . TYR A 1 344 ? -16.151 -30.171 -23.288 1.00 33.76  ? 607  TYR A C   1 
ATOM   2447 O  O   . TYR A 1 344 ? -15.137 -30.386 -23.990 1.00 31.44  ? 607  TYR A O   1 
ATOM   2448 C  CB  . TYR A 1 344 ? -17.292 -32.106 -22.035 1.00 34.47  ? 607  TYR A CB  1 
ATOM   2449 C  CG  . TYR A 1 344 ? -16.906 -33.104 -23.106 1.00 36.25  ? 607  TYR A CG  1 
ATOM   2450 C  CD1 . TYR A 1 344 ? -16.021 -34.133 -22.848 1.00 37.49  ? 607  TYR A CD1 1 
ATOM   2451 C  CD2 . TYR A 1 344 ? -17.392 -32.996 -24.400 1.00 38.01  ? 607  TYR A CD2 1 
ATOM   2452 C  CE1 . TYR A 1 344 ? -15.656 -35.042 -23.827 1.00 36.79  ? 607  TYR A CE1 1 
ATOM   2453 C  CE2 . TYR A 1 344 ? -17.026 -33.885 -25.396 1.00 38.32  ? 607  TYR A CE2 1 
ATOM   2454 C  CZ  . TYR A 1 344 ? -16.156 -34.923 -25.114 1.00 38.65  ? 607  TYR A CZ  1 
ATOM   2455 O  OH  . TYR A 1 344 ? -15.792 -35.806 -26.103 1.00 39.71  ? 607  TYR A OH  1 
ATOM   2456 N  N   . GLY A 1 345 ? -17.159 -29.396 -23.689 1.00 33.49  ? 608  GLY A N   1 
ATOM   2457 C  CA  . GLY A 1 345 ? -17.204 -28.781 -25.031 1.00 34.12  ? 608  GLY A CA  1 
ATOM   2458 C  C   . GLY A 1 345 ? -16.125 -27.731 -25.201 1.00 31.14  ? 608  GLY A C   1 
ATOM   2459 O  O   . GLY A 1 345 ? -15.470 -27.731 -26.216 1.00 36.93  ? 608  GLY A O   1 
ATOM   2460 N  N   . LEU A 1 346 ? -15.929 -26.897 -24.200 1.00 30.00  ? 609  LEU A N   1 
ATOM   2461 C  CA  . LEU A 1 346 ? -14.921 -25.821 -24.237 1.00 35.90  ? 609  LEU A CA  1 
ATOM   2462 C  C   . LEU A 1 346 ? -13.506 -26.401 -24.074 1.00 35.06  ? 609  LEU A C   1 
ATOM   2463 O  O   . LEU A 1 346 ? -12.574 -25.925 -24.803 1.00 36.31  ? 609  LEU A O   1 
ATOM   2464 C  CB  . LEU A 1 346 ? -15.283 -24.801 -23.154 1.00 35.45  ? 609  LEU A CB  1 
ATOM   2465 C  CG  . LEU A 1 346 ? -16.643 -24.124 -23.350 1.00 35.44  ? 609  LEU A CG  1 
ATOM   2466 C  CD1 . LEU A 1 346 ? -16.844 -23.070 -22.285 1.00 37.42  ? 609  LEU A CD1 1 
ATOM   2467 C  CD2 . LEU A 1 346 ? -16.766 -23.472 -24.723 1.00 36.00  ? 609  LEU A CD2 1 
ATOM   2468 N  N   . ASN A 1 347 ? -13.344 -27.433 -23.248 1.00 32.34  ? 610  ASN A N   1 
ATOM   2469 C  CA  . ASN A 1 347 ? -12.085 -28.224 -23.194 1.00 30.26  ? 610  ASN A CA  1 
ATOM   2470 C  C   . ASN A 1 347 ? -11.739 -28.766 -24.583 1.00 29.41  ? 610  ASN A C   1 
ATOM   2471 O  O   . ASN A 1 347 ? -10.618 -28.551 -25.057 1.00 32.61  ? 610  ASN A O   1 
ATOM   2472 C  CB  . ASN A 1 347 ? -12.178 -29.318 -22.144 1.00 28.66  ? 610  ASN A CB  1 
ATOM   2473 C  CG  . ASN A 1 347 ? -12.050 -28.735 -20.748 1.00 35.12  ? 610  ASN A CG  1 
ATOM   2474 O  OD1 . ASN A 1 347 ? -11.705 -27.574 -20.572 1.00 32.16  ? 610  ASN A OD1 1 
ATOM   2475 N  ND2 . ASN A 1 347 ? -12.243 -29.561 -19.736 1.00 40.63  ? 610  ASN A ND2 1 
ATOM   2476 N  N   . THR A 1 348 ? -12.650 -29.457 -25.243 1.00 30.77  ? 611  THR A N   1 
ATOM   2477 C  CA  . THR A 1 348 ? -12.402 -30.004 -26.595 1.00 29.37  ? 611  THR A CA  1 
ATOM   2478 C  C   . THR A 1 348 ? -11.970 -28.858 -27.502 1.00 32.85  ? 611  THR A C   1 
ATOM   2479 O  O   . THR A 1 348 ? -11.008 -29.042 -28.289 1.00 36.14  ? 611  THR A O   1 
ATOM   2480 C  CB  . THR A 1 348 ? -13.627 -30.728 -27.141 1.00 30.17  ? 611  THR A CB  1 
ATOM   2481 O  OG1 . THR A 1 348 ? -14.046 -31.658 -26.136 1.00 31.24  ? 611  THR A OG1 1 
ATOM   2482 C  CG2 . THR A 1 348 ? -13.361 -31.393 -28.473 1.00 26.94  ? 611  THR A CG2 1 
ATOM   2483 N  N   . PHE A 1 349 ? -12.674 -27.728 -27.431 1.00 35.32  ? 612  PHE A N   1 
ATOM   2484 C  CA  . PHE A 1 349 ? -12.431 -26.572 -28.331 1.00 35.08  ? 612  PHE A CA  1 
ATOM   2485 C  C   . PHE A 1 349 ? -10.995 -26.055 -28.153 1.00 35.76  ? 612  PHE A C   1 
ATOM   2486 O  O   . PHE A 1 349 ? -10.256 -25.925 -29.138 1.00 32.64  ? 612  PHE A O   1 
ATOM   2487 C  CB  . PHE A 1 349 ? -13.406 -25.442 -28.039 1.00 33.63  ? 612  PHE A CB  1 
ATOM   2488 C  CG  . PHE A 1 349 ? -13.140 -24.273 -28.939 1.00 32.07  ? 612  PHE A CG  1 
ATOM   2489 C  CD1 . PHE A 1 349 ? -13.661 -24.253 -30.220 1.00 32.82  ? 612  PHE A CD1 1 
ATOM   2490 C  CD2 . PHE A 1 349 ? -12.346 -23.220 -28.514 1.00 30.86  ? 612  PHE A CD2 1 
ATOM   2491 C  CE1 . PHE A 1 349 ? -13.389 -23.188 -31.064 1.00 33.69  ? 612  PHE A CE1 1 
ATOM   2492 C  CE2 . PHE A 1 349 ? -12.076 -22.163 -29.364 1.00 31.02  ? 612  PHE A CE2 1 
ATOM   2493 C  CZ  . PHE A 1 349 ? -12.594 -22.151 -30.633 1.00 32.08  ? 612  PHE A CZ  1 
ATOM   2494 N  N   . THR A 1 350 ? -10.613 -25.793 -26.905 1.00 32.00  ? 613  THR A N   1 
ATOM   2495 C  CA  . THR A 1 350 ? -9.338  -25.148 -26.544 1.00 35.83  ? 613  THR A CA  1 
ATOM   2496 C  C   . THR A 1 350 ? -8.186  -26.132 -26.816 1.00 35.48  ? 613  THR A C   1 
ATOM   2497 O  O   . THR A 1 350 ? -7.136  -25.687 -27.305 1.00 36.34  ? 613  THR A O   1 
ATOM   2498 C  CB  . THR A 1 350 ? -9.409  -24.618 -25.112 1.00 36.02  ? 613  THR A CB  1 
ATOM   2499 O  OG1 . THR A 1 350 ? -10.414 -23.603 -25.152 1.00 37.32  ? 613  THR A OG1 1 
ATOM   2500 C  CG2 . THR A 1 350 ? -8.091  -24.057 -24.607 1.00 37.02  ? 613  THR A CG2 1 
ATOM   2501 N  N   . ASN A 1 351 ? -8.405  -27.421 -26.564 1.00 36.69  ? 614  ASN A N   1 
ATOM   2502 C  CA  . ASN A 1 351 ? -7.428  -28.501 -26.842 1.00 33.09  ? 614  ASN A CA  1 
ATOM   2503 C  C   . ASN A 1 351 ? -7.262  -28.626 -28.360 1.00 33.80  ? 614  ASN A C   1 
ATOM   2504 O  O   . ASN A 1 351 ? -6.142  -28.744 -28.786 1.00 29.56  ? 614  ASN A O   1 
ATOM   2505 C  CB  . ASN A 1 351 ? -7.854  -29.842 -26.240 1.00 34.62  ? 614  ASN A CB  1 
ATOM   2506 C  CG  . ASN A 1 351 ? -6.689  -30.781 -25.972 1.00 34.57  ? 614  ASN A CG  1 
ATOM   2507 O  OD1 . ASN A 1 351 ? -5.531  -30.427 -26.184 1.00 33.10  ? 614  ASN A OD1 1 
ATOM   2508 N  ND2 . ASN A 1 351 ? -6.980  -31.972 -25.474 1.00 34.24  ? 614  ASN A ND2 1 
ATOM   2509 N  N   . MET A 1 352 ? -8.341  -28.577 -29.142 1.00 31.52  ? 615  MET A N   1 
ATOM   2510 C  CA  . MET A 1 352 ? -8.217  -28.662 -30.615 1.00 36.00  ? 615  MET A CA  1 
ATOM   2511 C  C   . MET A 1 352 ? -7.309  -27.522 -31.086 1.00 33.23  ? 615  MET A C   1 
ATOM   2512 O  O   . MET A 1 352 ? -6.479  -27.764 -31.970 1.00 37.56  ? 615  MET A O   1 
ATOM   2513 C  CB  . MET A 1 352 ? -9.564  -28.539 -31.333 1.00 34.26  ? 615  MET A CB  1 
ATOM   2514 C  CG  . MET A 1 352 ? -10.410 -29.779 -31.301 1.00 39.28  ? 615  MET A CG  1 
ATOM   2515 S  SD  . MET A 1 352 ? -12.133 -29.483 -31.940 1.00 37.40  ? 615  MET A SD  1 
ATOM   2516 C  CE  . MET A 1 352 ? -11.844 -29.151 -33.667 1.00 32.39  ? 615  MET A CE  1 
ATOM   2517 N  N   . GLU A 1 353 ? -7.466  -26.345 -30.486 1.00 34.42  ? 616  GLU A N   1 
ATOM   2518 C  CA  . GLU A 1 353 ? -6.722  -25.097 -30.828 1.00 38.88  ? 616  GLU A CA  1 
ATOM   2519 C  C   . GLU A 1 353 ? -5.248  -25.293 -30.442 1.00 35.17  ? 616  GLU A C   1 
ATOM   2520 O  O   . GLU A 1 353 ? -4.380  -25.091 -31.291 1.00 33.12  ? 616  GLU A O   1 
ATOM   2521 C  CB  . GLU A 1 353 ? -7.419  -23.932 -30.119 1.00 39.49  ? 616  GLU A CB  1 
ATOM   2522 C  CG  . GLU A 1 353 ? -6.744  -22.564 -30.198 1.00 46.52  ? 616  GLU A CG  1 
ATOM   2523 C  CD  . GLU A 1 353 ? -7.104  -21.630 -29.031 1.00 49.65  ? 616  GLU A CD  1 
ATOM   2524 O  OE1 . GLU A 1 353 ? -8.303  -21.207 -28.906 1.00 45.75  ? 616  GLU A OE1 1 
ATOM   2525 O  OE2 . GLU A 1 353 ? -6.203  -21.392 -28.187 1.00 49.96  ? 616  GLU A OE2 1 
ATOM   2526 N  N   . ALA A 1 354 ? -4.992  -25.709 -29.200 1.00 32.73  ? 617  ALA A N   1 
ATOM   2527 C  CA  . ALA A 1 354 ? -3.638  -25.961 -28.679 1.00 31.27  ? 617  ALA A CA  1 
ATOM   2528 C  C   . ALA A 1 354 ? -2.919  -26.975 -29.572 1.00 34.70  ? 617  ALA A C   1 
ATOM   2529 O  O   . ALA A 1 354 ? -1.756  -26.710 -29.891 1.00 33.36  ? 617  ALA A O   1 
ATOM   2530 C  CB  . ALA A 1 354 ? -3.696  -26.420 -27.259 1.00 32.79  ? 617  ALA A CB  1 
ATOM   2531 N  N   . GLN A 1 355 ? -3.578  -28.063 -29.989 1.00 33.22  ? 618  GLN A N   1 
ATOM   2532 C  CA  . GLN A 1 355 ? -2.907  -29.130 -30.751 1.00 31.34  ? 618  GLN A CA  1 
ATOM   2533 C  C   . GLN A 1 355 ? -2.672  -28.676 -32.189 1.00 33.01  ? 618  GLN A C   1 
ATOM   2534 O  O   . GLN A 1 355 ? -1.714  -29.183 -32.763 1.00 36.89  ? 618  GLN A O   1 
ATOM   2535 C  CB  . GLN A 1 355 ? -3.631  -30.482 -30.719 1.00 30.47  ? 618  GLN A CB  1 
ATOM   2536 C  CG  . GLN A 1 355 ? -3.876  -31.042 -29.337 1.00 32.44  ? 618  GLN A CG  1 
ATOM   2537 C  CD  . GLN A 1 355 ? -2.593  -31.167 -28.554 1.00 37.36  ? 618  GLN A CD  1 
ATOM   2538 O  OE1 . GLN A 1 355 ? -1.579  -31.627 -29.058 1.00 33.77  ? 618  GLN A OE1 1 
ATOM   2539 N  NE2 . GLN A 1 355 ? -2.647  -30.761 -27.305 1.00 36.89  ? 618  GLN A NE2 1 
ATOM   2540 N  N   . LEU A 1 356 ? -3.535  -27.881 -32.817 1.00 38.51  ? 619  LEU A N   1 
ATOM   2541 C  CA  . LEU A 1 356 ? -3.269  -27.358 -34.199 1.00 34.99  ? 619  LEU A CA  1 
ATOM   2542 C  C   . LEU A 1 356 ? -2.049  -26.430 -34.124 1.00 38.11  ? 619  LEU A C   1 
ATOM   2543 O  O   . LEU A 1 356 ? -1.237  -26.417 -35.072 1.00 35.53  ? 619  LEU A O   1 
ATOM   2544 C  CB  . LEU A 1 356 ? -4.443  -26.527 -34.713 1.00 37.99  ? 619  LEU A CB  1 
ATOM   2545 C  CG  . LEU A 1 356 ? -5.516  -27.235 -35.517 1.00 43.05  ? 619  LEU A CG  1 
ATOM   2546 C  CD1 . LEU A 1 356 ? -6.612  -26.233 -35.847 1.00 45.22  ? 619  LEU A CD1 1 
ATOM   2547 C  CD2 . LEU A 1 356 ? -4.959  -27.836 -36.783 1.00 44.19  ? 619  LEU A CD2 1 
ATOM   2548 N  N   . ILE A 1 357 ? -1.925  -25.656 -33.043 1.00 35.97  ? 620  ILE A N   1 
ATOM   2549 C  CA  . ILE A 1 357 ? -0.795  -24.693 -32.902 1.00 39.68  ? 620  ILE A CA  1 
ATOM   2550 C  C   . ILE A 1 357 ? 0.506   -25.474 -32.663 1.00 47.41  ? 620  ILE A C   1 
ATOM   2551 O  O   . ILE A 1 357 ? 1.529   -25.114 -33.265 1.00 49.01  ? 620  ILE A O   1 
ATOM   2552 C  CB  . ILE A 1 357 ? -1.057  -23.675 -31.789 1.00 41.94  ? 620  ILE A CB  1 
ATOM   2553 C  CG1 . ILE A 1 357 ? -2.203  -22.724 -32.152 1.00 42.22  ? 620  ILE A CG1 1 
ATOM   2554 C  CG2 . ILE A 1 357 ? 0.230   -22.932 -31.480 1.00 44.80  ? 620  ILE A CG2 1 
ATOM   2555 C  CD1 . ILE A 1 357 ? -2.718  -21.923 -30.992 1.00 42.85  ? 620  ILE A CD1 1 
ATOM   2556 N  N   . ARG A 1 358 ? 0.482   -26.533 -31.855 1.00 42.07  ? 621  ARG A N   1 
ATOM   2557 C  CA  . ARG A 1 358 ? 1.658   -27.417 -31.703 1.00 36.70  ? 621  ARG A CA  1 
ATOM   2558 C  C   . ARG A 1 358 ? 1.999   -28.053 -33.056 1.00 37.91  ? 621  ARG A C   1 
ATOM   2559 O  O   . ARG A 1 358 ? 3.207   -28.155 -33.383 1.00 40.13  ? 621  ARG A O   1 
ATOM   2560 C  CB  . ARG A 1 358 ? 1.438   -28.466 -30.621 1.00 35.59  ? 621  ARG A CB  1 
ATOM   2561 C  CG  . ARG A 1 358 ? 2.609   -29.430 -30.511 1.00 35.92  ? 621  ARG A CG  1 
ATOM   2562 C  CD  . ARG A 1 358 ? 2.537   -30.343 -29.303 1.00 35.57  ? 621  ARG A CD  1 
ATOM   2563 N  NE  . ARG A 1 358 ? 3.751   -31.120 -29.204 1.00 36.09  ? 621  ARG A NE  1 
ATOM   2564 C  CZ  . ARG A 1 358 ? 3.993   -32.068 -28.316 1.00 36.09  ? 621  ARG A CZ  1 
ATOM   2565 N  NH1 . ARG A 1 358 ? 3.081   -32.465 -27.457 1.00 35.14  ? 621  ARG A NH1 1 
ATOM   2566 N  NH2 . ARG A 1 358 ? 5.170   -32.643 -28.304 1.00 41.40  ? 621  ARG A NH2 1 
ATOM   2567 N  N   . GLN A 1 359 ? 1.006   -28.455 -33.845 1.00 37.71  ? 622  GLN A N   1 
ATOM   2568 C  CA  . GLN A 1 359 ? 1.262   -28.970 -35.217 1.00 39.85  ? 622  GLN A CA  1 
ATOM   2569 C  C   . GLN A 1 359 ? 1.931   -27.861 -36.078 1.00 40.81  ? 622  GLN A C   1 
ATOM   2570 O  O   . GLN A 1 359 ? 2.812   -28.176 -36.889 1.00 46.70  ? 622  GLN A O   1 
ATOM   2571 C  CB  . GLN A 1 359 ? -0.023  -29.481 -35.878 1.00 37.25  ? 622  GLN A CB  1 
ATOM   2572 C  CG  . GLN A 1 359 ? -0.476  -30.867 -35.458 1.00 39.23  ? 622  GLN A CG  1 
ATOM   2573 C  CD  . GLN A 1 359 ? -1.526  -31.456 -36.381 1.00 39.72  ? 622  GLN A CD  1 
ATOM   2574 O  OE1 . GLN A 1 359 ? -1.234  -31.986 -37.449 1.00 37.35  ? 622  GLN A OE1 1 
ATOM   2575 N  NE2 . GLN A 1 359 ? -2.774  -31.400 -35.960 1.00 39.28  ? 622  GLN A NE2 1 
ATOM   2576 N  N   . MET A 1 360 ? 1.509   -26.608 -35.973 1.00 42.77  ? 623  MET A N   1 
ATOM   2577 C  CA  . MET A 1 360 ? 2.058   -25.497 -36.805 1.00 45.26  ? 623  MET A CA  1 
ATOM   2578 C  C   . MET A 1 360 ? 3.550   -25.349 -36.479 1.00 43.68  ? 623  MET A C   1 
ATOM   2579 O  O   . MET A 1 360 ? 4.362   -25.198 -37.429 1.00 42.87  ? 623  MET A O   1 
ATOM   2580 C  CB  . MET A 1 360 ? 1.372   -24.158 -36.502 1.00 46.04  ? 623  MET A CB  1 
ATOM   2581 C  CG  . MET A 1 360 ? 0.036   -23.914 -37.206 1.00 43.97  ? 623  MET A CG  1 
ATOM   2582 S  SD  . MET A 1 360 ? -0.689  -22.437 -36.448 1.00 49.97  ? 623  MET A SD  1 
ATOM   2583 C  CE  . MET A 1 360 ? -2.413  -22.770 -36.798 1.00 56.10  ? 623  MET A CE  1 
ATOM   2584 N  N   . GLU A 1 361 ? 3.860   -25.402 -35.184 1.00 37.78  ? 624  GLU A N   1 
ATOM   2585 C  CA  . GLU A 1 361 ? 5.211   -25.228 -34.612 1.00 37.96  ? 624  GLU A CA  1 
ATOM   2586 C  C   . GLU A 1 361 ? 6.099   -26.338 -35.128 1.00 41.27  ? 624  GLU A C   1 
ATOM   2587 O  O   . GLU A 1 361 ? 7.227   -26.021 -35.534 1.00 44.89  ? 624  GLU A O   1 
ATOM   2588 C  CB  . GLU A 1 361 ? 5.187   -25.210 -33.089 1.00 39.43  ? 624  GLU A CB  1 
ATOM   2589 C  CG  . GLU A 1 361 ? 6.555   -24.956 -32.486 1.00 46.15  ? 624  GLU A CG  1 
ATOM   2590 C  CD  . GLU A 1 361 ? 6.561   -24.656 -30.994 1.00 50.75  ? 624  GLU A CD  1 
ATOM   2591 O  OE1 . GLU A 1 361 ? 7.632   -24.772 -30.368 1.00 53.16  ? 624  GLU A OE1 1 
ATOM   2592 O  OE2 . GLU A 1 361 ? 5.490   -24.301 -30.449 1.00 57.18  ? 624  GLU A OE2 1 
ATOM   2593 N  N   . GLY A 1 362 ? 5.620   -27.578 -35.140 1.00 39.86  ? 625  GLY A N   1 
ATOM   2594 C  CA  . GLY A 1 362 ? 6.407   -28.696 -35.685 1.00 45.46  ? 625  GLY A CA  1 
ATOM   2595 C  C   . GLY A 1 362 ? 6.623   -28.584 -37.205 1.00 49.38  ? 625  GLY A C   1 
ATOM   2596 O  O   . GLY A 1 362 ? 7.580   -29.205 -37.710 1.00 46.35  ? 625  GLY A O   1 
ATOM   2597 N  N   . GLU A 1 363 ? 5.731   -27.915 -37.936 1.00 42.00  ? 626  GLU A N   1 
ATOM   2598 C  CA  . GLU A 1 363 ? 5.843   -27.742 -39.412 1.00 46.60  ? 626  GLU A CA  1 
ATOM   2599 C  C   . GLU A 1 363 ? 6.638   -26.466 -39.725 1.00 46.86  ? 626  GLU A C   1 
ATOM   2600 O  O   . GLU A 1 363 ? 6.829   -26.187 -40.921 1.00 48.56  ? 626  GLU A O   1 
ATOM   2601 C  CB  . GLU A 1 363 ? 4.456   -27.704 -40.068 1.00 45.35  ? 626  GLU A CB  1 
ATOM   2602 C  CG  . GLU A 1 363 ? 3.791   -29.079 -40.062 1.00 47.67  ? 626  GLU A CG  1 
ATOM   2603 C  CD  . GLU A 1 363 ? 2.431   -29.187 -40.720 1.00 50.80  ? 626  GLU A CD  1 
ATOM   2604 O  OE1 . GLU A 1 363 ? 2.227   -28.523 -41.781 1.00 46.98  ? 626  GLU A OE1 1 
ATOM   2605 O  OE2 . GLU A 1 363 ? 1.568   -29.938 -40.168 1.00 45.84  ? 626  GLU A OE2 1 
ATOM   2606 N  N   . GLY A 1 364 ? 7.093   -25.731 -38.703 1.00 47.12  ? 627  GLY A N   1 
ATOM   2607 C  CA  . GLY A 1 364 ? 7.816   -24.459 -38.885 1.00 51.82  ? 627  GLY A CA  1 
ATOM   2608 C  C   . GLY A 1 364 ? 6.968   -23.415 -39.617 1.00 64.42  ? 627  GLY A C   1 
ATOM   2609 O  O   . GLY A 1 364 ? 7.535   -22.662 -40.441 1.00 70.74  ? 627  GLY A O   1 
ATOM   2610 N  N   . VAL A 1 365 ? 5.666   -23.324 -39.316 1.00 54.83  ? 628  VAL A N   1 
ATOM   2611 C  CA  . VAL A 1 365 ? 4.768   -22.248 -39.835 1.00 52.47  ? 628  VAL A CA  1 
ATOM   2612 C  C   . VAL A 1 365 ? 5.183   -20.903 -39.239 1.00 52.83  ? 628  VAL A C   1 
ATOM   2613 O  O   . VAL A 1 365 ? 4.910   -19.876 -39.870 1.00 60.32  ? 628  VAL A O   1 
ATOM   2614 C  CB  . VAL A 1 365 ? 3.286   -22.563 -39.542 1.00 51.33  ? 628  VAL A CB  1 
ATOM   2615 C  CG1 . VAL A 1 365 ? 2.383   -21.377 -39.821 1.00 51.79  ? 628  VAL A CG1 1 
ATOM   2616 C  CG2 . VAL A 1 365 ? 2.821   -23.773 -40.337 1.00 50.16  ? 628  VAL A CG2 1 
ATOM   2617 N  N   . PHE A 1 366 ? 5.751   -20.919 -38.037 1.00 52.67  ? 629  PHE A N   1 
ATOM   2618 C  CA  . PHE A 1 366 ? 6.176   -19.728 -37.268 1.00 55.59  ? 629  PHE A CA  1 
ATOM   2619 C  C   . PHE A 1 366 ? 7.469   -20.061 -36.510 1.00 64.69  ? 629  PHE A C   1 
ATOM   2620 O  O   . PHE A 1 366 ? 7.645   -21.226 -36.104 1.00 65.30  ? 629  PHE A O   1 
ATOM   2621 C  CB  . PHE A 1 366 ? 5.047   -19.295 -36.338 1.00 55.48  ? 629  PHE A CB  1 
ATOM   2622 C  CG  . PHE A 1 366 ? 4.838   -20.141 -35.105 1.00 48.73  ? 629  PHE A CG  1 
ATOM   2623 C  CD1 . PHE A 1 366 ? 5.553   -19.901 -33.943 1.00 52.84  ? 629  PHE A CD1 1 
ATOM   2624 C  CD2 . PHE A 1 366 ? 3.887   -21.142 -35.093 1.00 48.22  ? 629  PHE A CD2 1 
ATOM   2625 C  CE1 . PHE A 1 366 ? 5.326   -20.654 -32.800 1.00 54.55  ? 629  PHE A CE1 1 
ATOM   2626 C  CE2 . PHE A 1 366 ? 3.668   -21.904 -33.961 1.00 47.13  ? 629  PHE A CE2 1 
ATOM   2627 C  CZ  . PHE A 1 366 ? 4.375   -21.652 -32.814 1.00 51.76  ? 629  PHE A CZ  1 
ATOM   2628 N  N   . LYS A 1 367 ? 8.328   -19.061 -36.296 1.00 68.16  ? 630  LYS A N   1 
ATOM   2629 C  CA  . LYS A 1 367 ? 9.722   -19.263 -35.830 1.00 67.69  ? 630  LYS A CA  1 
ATOM   2630 C  C   . LYS A 1 367 ? 9.764   -19.192 -34.304 1.00 63.68  ? 630  LYS A C   1 
ATOM   2631 O  O   . LYS A 1 367 ? 10.396  -20.060 -33.692 1.00 68.09  ? 630  LYS A O   1 
ATOM   2632 C  CB  . LYS A 1 367 ? 10.654  -18.232 -36.472 1.00 80.70  ? 630  LYS A CB  1 
ATOM   2633 C  CG  . LYS A 1 367 ? 12.084  -18.727 -36.677 1.00 101.53 ? 630  LYS A CG  1 
ATOM   2634 C  CD  . LYS A 1 367 ? 13.125  -17.639 -36.937 1.00 105.66 ? 630  LYS A CD  1 
ATOM   2635 C  CE  . LYS A 1 367 ? 14.547  -18.156 -36.857 1.00 108.01 ? 630  LYS A CE  1 
ATOM   2636 N  NZ  . LYS A 1 367 ? 14.869  -18.672 -35.504 1.00 112.38 ? 630  LYS A NZ  1 
ATOM   2637 N  N   . SER A 1 368 ? 9.115   -18.197 -33.707 1.00 58.91  ? 631  SER A N   1 
ATOM   2638 C  CA  . SER A 1 368 ? 9.176   -17.940 -32.250 1.00 55.33  ? 631  SER A CA  1 
ATOM   2639 C  C   . SER A 1 368 ? 7.847   -17.388 -31.746 1.00 55.88  ? 631  SER A C   1 
ATOM   2640 O  O   . SER A 1 368 ? 7.193   -16.589 -32.469 1.00 53.26  ? 631  SER A O   1 
ATOM   2641 C  CB  . SER A 1 368 ? 10.289  -16.986 -31.925 1.00 71.49  ? 631  SER A CB  1 
ATOM   2642 O  OG  . SER A 1 368 ? 9.953   -16.161 -30.808 1.00 81.00  ? 631  SER A OG  1 
ATOM   2643 N  N   . ILE A 1 369 ? 7.536   -17.715 -30.493 1.00 54.28  ? 632  ILE A N   1 
ATOM   2644 C  CA  . ILE A 1 369 ? 6.270   -17.334 -29.807 1.00 58.74  ? 632  ILE A CA  1 
ATOM   2645 C  C   . ILE A 1 369 ? 6.368   -15.909 -29.272 1.00 63.29  ? 632  ILE A C   1 
ATOM   2646 O  O   . ILE A 1 369 ? 5.311   -15.354 -28.888 1.00 51.67  ? 632  ILE A O   1 
ATOM   2647 C  CB  . ILE A 1 369 ? 5.975   -18.333 -28.682 1.00 57.49  ? 632  ILE A CB  1 
ATOM   2648 C  CG1 . ILE A 1 369 ? 7.056   -18.304 -27.600 1.00 55.91  ? 632  ILE A CG1 1 
ATOM   2649 C  CG2 . ILE A 1 369 ? 5.790   -19.720 -29.281 1.00 61.08  ? 632  ILE A CG2 1 
ATOM   2650 C  CD1 . ILE A 1 369 ? 6.690   -19.066 -26.367 1.00 54.21  ? 632  ILE A CD1 1 
ATOM   2651 N  N   . GLN A 1 370 ? 7.592   -15.374 -29.188 1.00 74.06  ? 633  GLN A N   1 
ATOM   2652 C  CA  . GLN A 1 370 ? 7.885   -14.062 -28.547 1.00 75.96  ? 633  GLN A CA  1 
ATOM   2653 C  C   . GLN A 1 370 ? 7.016   -12.980 -29.204 1.00 78.65  ? 633  GLN A C   1 
ATOM   2654 O  O   . GLN A 1 370 ? 6.337   -12.222 -28.465 1.00 73.77  ? 633  GLN A O   1 
ATOM   2655 C  CB  . GLN A 1 370 ? 9.379   -13.748 -28.664 1.00 76.13  ? 633  GLN A CB  1 
ATOM   2656 C  CG  . GLN A 1 370 ? 10.016  -13.365 -27.336 1.00 81.74  ? 633  GLN A CG  1 
ATOM   2657 C  CD  . GLN A 1 370 ? 9.927   -14.477 -26.318 1.00 86.61  ? 633  GLN A CD  1 
ATOM   2658 O  OE1 . GLN A 1 370 ? 10.085  -15.654 -26.641 1.00 92.22  ? 633  GLN A OE1 1 
ATOM   2659 N  NE2 . GLN A 1 370 ? 9.665   -14.110 -25.073 1.00 87.05  ? 633  GLN A NE2 1 
ATOM   2660 N  N   . HIS A 1 371 ? 7.032   -12.950 -30.540 1.00 75.13  ? 634  HIS A N   1 
ATOM   2661 C  CA  . HIS A 1 371 ? 6.359   -11.957 -31.416 1.00 79.89  ? 634  HIS A CA  1 
ATOM   2662 C  C   . HIS A 1 371 ? 6.100   -12.624 -32.771 1.00 76.74  ? 634  HIS A C   1 
ATOM   2663 O  O   . HIS A 1 371 ? 7.014   -13.291 -33.277 1.00 73.10  ? 634  HIS A O   1 
ATOM   2664 C  CB  . HIS A 1 371 ? 7.206   -10.672 -31.560 1.00 90.99  ? 634  HIS A CB  1 
ATOM   2665 C  CG  . HIS A 1 371 ? 6.675   -9.675  -32.548 1.00 101.01 ? 634  HIS A CG  1 
ATOM   2666 N  ND1 . HIS A 1 371 ? 5.780   -8.666  -32.193 1.00 110.21 ? 634  HIS A ND1 1 
ATOM   2667 C  CD2 . HIS A 1 371 ? 6.902   -9.522  -33.873 1.00 104.41 ? 634  HIS A CD2 1 
ATOM   2668 C  CE1 . HIS A 1 371 ? 5.482   -7.944  -33.257 1.00 100.67 ? 634  HIS A CE1 1 
ATOM   2669 N  NE2 . HIS A 1 371 ? 6.154   -8.451  -34.301 1.00 106.43 ? 634  HIS A NE2 1 
ATOM   2670 N  N   . LEU A 1 372 ? 4.932   -12.361 -33.361 1.00 73.66  ? 635  LEU A N   1 
ATOM   2671 C  CA  . LEU A 1 372 ? 4.615   -12.902 -34.703 1.00 71.25  ? 635  LEU A CA  1 
ATOM   2672 C  C   . LEU A 1 372 ? 4.737   -11.786 -35.740 1.00 70.76  ? 635  LEU A C   1 
ATOM   2673 O  O   . LEU A 1 372 ? 4.099   -10.741 -35.553 1.00 71.19  ? 635  LEU A O   1 
ATOM   2674 C  CB  . LEU A 1 372 ? 3.194   -13.471 -34.686 1.00 78.70  ? 635  LEU A CB  1 
ATOM   2675 C  CG  . LEU A 1 372 ? 2.935   -14.635 -35.639 1.00 74.04  ? 635  LEU A CG  1 
ATOM   2676 C  CD1 . LEU A 1 372 ? 3.809   -15.824 -35.279 1.00 77.32  ? 635  LEU A CD1 1 
ATOM   2677 C  CD2 . LEU A 1 372 ? 1.470   -15.032 -35.612 1.00 76.25  ? 635  LEU A CD2 1 
ATOM   2678 N  N   . THR A 1 373 ? 5.514   -12.021 -36.796 1.00 64.51  ? 636  THR A N   1 
ATOM   2679 C  CA  . THR A 1 373 ? 5.654   -11.035 -37.889 1.00 67.86  ? 636  THR A CA  1 
ATOM   2680 C  C   . THR A 1 373 ? 4.307   -10.894 -38.589 1.00 69.56  ? 636  THR A C   1 
ATOM   2681 O  O   . THR A 1 373 ? 3.455   -11.767 -38.392 1.00 82.22  ? 636  THR A O   1 
ATOM   2682 C  CB  . THR A 1 373 ? 6.736   -11.485 -38.874 1.00 70.95  ? 636  THR A CB  1 
ATOM   2683 O  OG1 . THR A 1 373 ? 6.184   -12.480 -39.734 1.00 69.91  ? 636  THR A OG1 1 
ATOM   2684 C  CG2 . THR A 1 373 ? 7.963   -12.028 -38.177 1.00 71.33  ? 636  THR A CG2 1 
ATOM   2685 N  N   . VAL A 1 374 ? 4.136   -9.843  -39.381 1.00 62.11  ? 637  VAL A N   1 
ATOM   2686 C  CA  . VAL A 1 374 ? 2.867   -9.655  -40.136 1.00 74.86  ? 637  VAL A CA  1 
ATOM   2687 C  C   . VAL A 1 374 ? 2.744   -10.750 -41.198 1.00 82.38  ? 637  VAL A C   1 
ATOM   2688 O  O   . VAL A 1 374 ? 1.616   -11.204 -41.450 1.00 73.78  ? 637  VAL A O   1 
ATOM   2689 C  CB  . VAL A 1 374 ? 2.795   -8.255  -40.768 1.00 81.84  ? 637  VAL A CB  1 
ATOM   2690 C  CG1 . VAL A 1 374 ? 2.128   -7.252  -39.842 1.00 81.51  ? 637  VAL A CG1 1 
ATOM   2691 C  CG2 . VAL A 1 374 ? 4.165   -7.765  -41.207 1.00 79.95  ? 637  VAL A CG2 1 
ATOM   2692 N  N   . THR A 1 375 ? 3.862   -11.133 -41.808 1.00 73.83  ? 638  THR A N   1 
ATOM   2693 C  CA  . THR A 1 375 ? 3.829   -12.162 -42.875 1.00 84.65  ? 638  THR A CA  1 
ATOM   2694 C  C   . THR A 1 375 ? 3.597   -13.540 -42.245 1.00 80.72  ? 638  THR A C   1 
ATOM   2695 O  O   . THR A 1 375 ? 3.047   -14.408 -42.933 1.00 74.24  ? 638  THR A O   1 
ATOM   2696 C  CB  . THR A 1 375 ? 5.110   -12.113 -43.712 1.00 84.89  ? 638  THR A CB  1 
ATOM   2697 O  OG1 . THR A 1 375 ? 6.220   -12.220 -42.823 1.00 84.82  ? 638  THR A OG1 1 
ATOM   2698 C  CG2 . THR A 1 375 ? 5.227   -10.842 -44.524 1.00 84.10  ? 638  THR A CG2 1 
ATOM   2699 N  N   . GLU A 1 376 ? 4.034   -13.724 -40.998 1.00 75.75  ? 639  GLU A N   1 
ATOM   2700 C  CA  . GLU A 1 376 ? 3.844   -15.016 -40.292 1.00 74.81  ? 639  GLU A CA  1 
ATOM   2701 C  C   . GLU A 1 376 ? 2.362   -15.150 -39.955 1.00 70.33  ? 639  GLU A C   1 
ATOM   2702 O  O   . GLU A 1 376 ? 1.845   -16.268 -40.051 1.00 66.40  ? 639  GLU A O   1 
ATOM   2703 C  CB  . GLU A 1 376 ? 4.758   -15.103 -39.070 1.00 72.39  ? 639  GLU A CB  1 
ATOM   2704 C  CG  . GLU A 1 376 ? 6.089   -15.768 -39.372 1.00 63.42  ? 639  GLU A CG  1 
ATOM   2705 C  CD  . GLU A 1 376 ? 7.034   -15.927 -38.193 1.00 65.63  ? 639  GLU A CD  1 
ATOM   2706 O  OE1 . GLU A 1 376 ? 7.952   -16.759 -38.287 1.00 69.81  ? 639  GLU A OE1 1 
ATOM   2707 O  OE2 . GLU A 1 376 ? 6.857   -15.213 -37.192 1.00 65.16  ? 639  GLU A OE2 1 
ATOM   2708 N  N   . GLU A 1 377 ? 1.712   -14.044 -39.602 1.00 67.26  ? 640  GLU A N   1 
ATOM   2709 C  CA  . GLU A 1 377 ? 0.248   -14.093 -39.379 1.00 66.06  ? 640  GLU A CA  1 
ATOM   2710 C  C   . GLU A 1 377 ? -0.405  -14.520 -40.693 1.00 68.79  ? 640  GLU A C   1 
ATOM   2711 O  O   . GLU A 1 377 ? -1.246  -15.424 -40.663 1.00 81.25  ? 640  GLU A O   1 
ATOM   2712 C  CB  . GLU A 1 377 ? -0.278  -12.745 -38.898 1.00 64.66  ? 640  GLU A CB  1 
ATOM   2713 C  CG  . GLU A 1 377 ? 0.346   -12.279 -37.598 1.00 74.96  ? 640  GLU A CG  1 
ATOM   2714 C  CD  . GLU A 1 377 ? -0.282  -11.019 -37.032 1.00 82.13  ? 640  GLU A CD  1 
ATOM   2715 O  OE1 . GLU A 1 377 ? -1.481  -10.801 -37.278 1.00 84.07  ? 640  GLU A OE1 1 
ATOM   2716 O  OE2 . GLU A 1 377 ? 0.432   -10.255 -36.355 1.00 78.65  ? 640  GLU A OE2 1 
ATOM   2717 N  N   . ILE A 1 378 ? 0.015   -13.927 -41.808 0.50 67.95  ? 641  ILE A N   1 
ATOM   2718 C  CA  . ILE A 1 378 ? -0.545  -14.326 -43.130 0.50 70.42  ? 641  ILE A CA  1 
ATOM   2719 C  C   . ILE A 1 378 ? -0.331  -15.828 -43.303 0.50 68.32  ? 641  ILE A C   1 
ATOM   2720 O  O   . ILE A 1 378 ? -1.285  -16.518 -43.701 0.50 71.19  ? 641  ILE A O   1 
ATOM   2721 C  CB  . ILE A 1 378 ? 0.116   -13.533 -44.276 0.50 69.23  ? 641  ILE A CB  1 
ATOM   2722 C  CG1 . ILE A 1 378 ? 0.016   -12.023 -44.049 0.50 72.69  ? 641  ILE A CG1 1 
ATOM   2723 C  CG2 . ILE A 1 378 ? -0.463  -13.943 -45.620 0.50 64.85  ? 641  ILE A CG2 1 
ATOM   2724 C  CD1 . ILE A 1 378 ? -1.395  -11.523 -43.851 0.50 70.82  ? 641  ILE A CD1 1 
ATOM   2725 N  N   . ALA A 1 379 ? 0.868   -16.312 -42.988 1.00 64.65  ? 642  ALA A N   1 
ATOM   2726 C  CA  . ALA A 1 379 ? 1.196   -17.738 -43.211 1.00 63.35  ? 642  ALA A CA  1 
ATOM   2727 C  C   . ALA A 1 379 ? 0.324   -18.652 -42.347 1.00 52.90  ? 642  ALA A C   1 
ATOM   2728 O  O   . ALA A 1 379 ? -0.155  -19.661 -42.871 1.00 52.52  ? 642  ALA A O   1 
ATOM   2729 C  CB  . ALA A 1 379 ? 2.658   -17.956 -42.938 1.00 61.17  ? 642  ALA A CB  1 
ATOM   2730 N  N   . VAL A 1 380 ? 0.139   -18.301 -41.078 1.00 45.76  ? 643  VAL A N   1 
ATOM   2731 C  CA  . VAL A 1 380 ? -0.683  -19.136 -40.161 1.00 52.29  ? 643  VAL A CA  1 
ATOM   2732 C  C   . VAL A 1 380 ? -2.080  -19.274 -40.770 1.00 57.04  ? 643  VAL A C   1 
ATOM   2733 O  O   . VAL A 1 380 ? -2.580  -20.400 -40.839 1.00 49.63  ? 643  VAL A O   1 
ATOM   2734 C  CB  . VAL A 1 380 ? -0.728  -18.541 -38.742 1.00 48.59  ? 643  VAL A CB  1 
ATOM   2735 C  CG1 . VAL A 1 380 ? -1.787  -19.208 -37.881 1.00 45.21  ? 643  VAL A CG1 1 
ATOM   2736 C  CG2 . VAL A 1 380 ? 0.630   -18.595 -38.064 1.00 46.75  ? 643  VAL A CG2 1 
ATOM   2737 N  N   . LYS A 1 381 ? -2.649  -18.167 -41.246 1.00 59.69  ? 644  LYS A N   1 
ATOM   2738 C  CA  . LYS A 1 381 ? -4.021  -18.176 -41.819 1.00 60.39  ? 644  LYS A CA  1 
ATOM   2739 C  C   . LYS A 1 381 ? -4.074  -19.033 -43.086 1.00 57.11  ? 644  LYS A C   1 
ATOM   2740 O  O   . LYS A 1 381 ? -5.001  -19.846 -43.198 1.00 50.89  ? 644  LYS A O   1 
ATOM   2741 C  CB  . LYS A 1 381 ? -4.463  -16.738 -42.101 1.00 65.90  ? 644  LYS A CB  1 
ATOM   2742 C  CG  . LYS A 1 381 ? -4.432  -15.799 -40.904 1.00 75.01  ? 644  LYS A CG  1 
ATOM   2743 C  CD  . LYS A 1 381 ? -4.987  -14.426 -41.213 1.00 82.40  ? 644  LYS A CD  1 
ATOM   2744 C  CE  . LYS A 1 381 ? -4.912  -13.472 -40.042 1.00 81.85  ? 644  LYS A CE  1 
ATOM   2745 N  NZ  . LYS A 1 381 ? -3.512  -13.204 -39.643 1.00 74.48  ? 644  LYS A NZ  1 
ATOM   2746 N  N   . ASN A 1 382 ? -3.120  -18.845 -43.998 1.00 53.90  ? 645  ASN A N   1 
ATOM   2747 C  CA  . ASN A 1 382 ? -3.078  -19.625 -45.261 1.00 57.30  ? 645  ASN A CA  1 
ATOM   2748 C  C   . ASN A 1 382 ? -2.899  -21.102 -44.914 1.00 55.35  ? 645  ASN A C   1 
ATOM   2749 O  O   . ASN A 1 382 ? -3.461  -21.944 -45.620 1.00 47.02  ? 645  ASN A O   1 
ATOM   2750 C  CB  . ASN A 1 382 ? -1.962  -19.121 -46.175 1.00 72.66  ? 645  ASN A CB  1 
ATOM   2751 C  CG  . ASN A 1 382 ? -2.075  -17.646 -46.500 1.00 86.48  ? 645  ASN A CG  1 
ATOM   2752 O  OD1 . ASN A 1 382 ? -3.071  -17.005 -46.173 1.00 87.60  ? 645  ASN A OD1 1 
ATOM   2753 N  ND2 . ASN A 1 382 ? -1.058  -17.100 -47.144 1.00 92.98  ? 645  ASN A ND2 1 
ATOM   2754 N  N   . TRP A 1 383 ? -2.127  -21.385 -43.868 1.00 52.13  ? 646  TRP A N   1 
ATOM   2755 C  CA  . TRP A 1 383 ? -1.933  -22.775 -43.380 1.00 46.36  ? 646  TRP A CA  1 
ATOM   2756 C  C   . TRP A 1 383 ? -3.313  -23.334 -42.981 1.00 43.64  ? 646  TRP A C   1 
ATOM   2757 O  O   . TRP A 1 383 ? -3.735  -24.389 -43.574 1.00 36.96  ? 646  TRP A O   1 
ATOM   2758 C  CB  . TRP A 1 383 ? -0.911  -22.776 -42.246 1.00 44.58  ? 646  TRP A CB  1 
ATOM   2759 C  CG  . TRP A 1 383 ? -0.500  -24.132 -41.787 1.00 45.33  ? 646  TRP A CG  1 
ATOM   2760 C  CD1 . TRP A 1 383 ? 0.474   -24.921 -42.304 1.00 46.81  ? 646  TRP A CD1 1 
ATOM   2761 C  CD2 . TRP A 1 383 ? -1.108  -24.885 -40.726 1.00 51.34  ? 646  TRP A CD2 1 
ATOM   2762 N  NE1 . TRP A 1 383 ? 0.550   -26.100 -41.607 1.00 50.03  ? 646  TRP A NE1 1 
ATOM   2763 C  CE2 . TRP A 1 383 ? -0.413  -26.108 -40.636 1.00 51.92  ? 646  TRP A CE2 1 
ATOM   2764 C  CE3 . TRP A 1 383 ? -2.136  -24.628 -39.815 1.00 43.92  ? 646  TRP A CE3 1 
ATOM   2765 C  CZ2 . TRP A 1 383 ? -0.729  -27.072 -39.678 1.00 45.79  ? 646  TRP A CZ2 1 
ATOM   2766 C  CZ3 . TRP A 1 383 ? -2.437  -25.577 -38.863 1.00 43.72  ? 646  TRP A CZ3 1 
ATOM   2767 C  CH2 . TRP A 1 383 ? -1.729  -26.773 -38.782 1.00 41.23  ? 646  TRP A CH2 1 
ATOM   2768 N  N   . LEU A 1 384 ? -4.046  -22.571 -42.154 1.00 37.27  ? 647  LEU A N   1 
ATOM   2769 C  CA  . LEU A 1 384 ? -5.391  -22.957 -41.655 1.00 43.76  ? 647  LEU A CA  1 
ATOM   2770 C  C   . LEU A 1 384 ? -6.351  -23.160 -42.839 1.00 46.43  ? 647  LEU A C   1 
ATOM   2771 O  O   . LEU A 1 384 ? -7.057  -24.184 -42.884 1.00 46.95  ? 647  LEU A O   1 
ATOM   2772 C  CB  . LEU A 1 384 ? -5.903  -21.890 -40.688 1.00 40.16  ? 647  LEU A CB  1 
ATOM   2773 C  CG  . LEU A 1 384 ? -5.283  -21.915 -39.293 1.00 44.97  ? 647  LEU A CG  1 
ATOM   2774 C  CD1 . LEU A 1 384 ? -5.650  -20.658 -38.515 1.00 46.41  ? 647  LEU A CD1 1 
ATOM   2775 C  CD2 . LEU A 1 384 ? -5.684  -23.153 -38.505 1.00 42.66  ? 647  LEU A CD2 1 
ATOM   2776 N  N   . VAL A 1 385 ? -6.348  -22.242 -43.799 1.00 54.35  ? 648  VAL A N   1 
ATOM   2777 C  CA  . VAL A 1 385 ? -7.252  -22.313 -44.977 1.00 48.22  ? 648  VAL A CA  1 
ATOM   2778 C  C   . VAL A 1 385 ? -6.820  -23.511 -45.809 1.00 47.60  ? 648  VAL A C   1 
ATOM   2779 O  O   . VAL A 1 385 ? -7.706  -24.278 -46.257 1.00 45.86  ? 648  VAL A O   1 
ATOM   2780 C  CB  . VAL A 1 385 ? -7.249  -20.985 -45.765 1.00 54.02  ? 648  VAL A CB  1 
ATOM   2781 C  CG1 . VAL A 1 385 ? -7.811  -21.135 -47.170 1.00 54.42  ? 648  VAL A CG1 1 
ATOM   2782 C  CG2 . VAL A 1 385 ? -8.013  -19.910 -45.005 1.00 53.82  ? 648  VAL A CG2 1 
ATOM   2783 N  N   . ARG A 1 386 ? -5.514  -23.698 -45.986 1.00 46.62  ? 649  ARG A N   1 
ATOM   2784 C  CA  . ARG A 1 386 ? -5.001  -24.692 -46.963 1.00 49.24  ? 649  ARG A CA  1 
ATOM   2785 C  C   . ARG A 1 386 ? -5.147  -26.104 -46.353 1.00 51.15  ? 649  ARG A C   1 
ATOM   2786 O  O   . ARG A 1 386 ? -5.561  -27.031 -47.106 1.00 50.02  ? 649  ARG A O   1 
ATOM   2787 C  CB  . ARG A 1 386 ? -3.581  -24.278 -47.385 1.00 59.25  ? 649  ARG A CB  1 
ATOM   2788 C  CG  . ARG A 1 386 ? -2.915  -25.152 -48.446 1.00 67.05  ? 649  ARG A CG  1 
ATOM   2789 C  CD  . ARG A 1 386 ? -1.454  -24.789 -48.782 1.00 70.37  ? 649  ARG A CD  1 
ATOM   2790 N  NE  . ARG A 1 386 ? -0.391  -25.132 -47.813 1.00 63.79  ? 649  ARG A NE  1 
ATOM   2791 C  CZ  . ARG A 1 386 ? 0.177   -24.283 -46.936 1.00 62.80  ? 649  ARG A CZ  1 
ATOM   2792 N  NH1 . ARG A 1 386 ? -0.213  -23.022 -46.838 1.00 67.69  ? 649  ARG A NH1 1 
ATOM   2793 N  NH2 . ARG A 1 386 ? 1.122   -24.705 -46.119 1.00 65.35  ? 649  ARG A NH2 1 
ATOM   2794 N  N   . VAL A 1 387 ? -4.828  -26.307 -45.059 1.00 46.27  ? 650  VAL A N   1 
ATOM   2795 C  CA  . VAL A 1 387 ? -4.701  -27.693 -44.501 1.00 49.79  ? 650  VAL A CA  1 
ATOM   2796 C  C   . VAL A 1 387 ? -5.310  -27.863 -43.090 1.00 44.39  ? 650  VAL A C   1 
ATOM   2797 O  O   . VAL A 1 387 ? -5.198  -29.002 -42.544 1.00 44.71  ? 650  VAL A O   1 
ATOM   2798 C  CB  . VAL A 1 387 ? -3.229  -28.155 -44.495 1.00 46.59  ? 650  VAL A CB  1 
ATOM   2799 C  CG1 . VAL A 1 387 ? -2.703  -28.386 -45.890 1.00 45.57  ? 650  VAL A CG1 1 
ATOM   2800 C  CG2 . VAL A 1 387 ? -2.345  -27.204 -43.701 1.00 47.61  ? 650  VAL A CG2 1 
ATOM   2801 N  N   . GLY A 1 388 ? -5.892  -26.817 -42.515 1.00 38.16  ? 651  GLY A N   1 
ATOM   2802 C  CA  . GLY A 1 388 ? -6.609  -26.853 -41.227 1.00 41.13  ? 651  GLY A CA  1 
ATOM   2803 C  C   . GLY A 1 388 ? -7.475  -28.097 -41.109 1.00 40.78  ? 651  GLY A C   1 
ATOM   2804 O  O   . GLY A 1 388 ? -7.314  -28.841 -40.143 1.00 40.89  ? 651  GLY A O   1 
ATOM   2805 N  N   . ARG A 1 389 ? -8.367  -28.321 -42.066 1.00 40.75  ? 652  ARG A N   1 
ATOM   2806 C  CA  . ARG A 1 389 ? -9.333  -29.445 -41.997 1.00 45.05  ? 652  ARG A CA  1 
ATOM   2807 C  C   . ARG A 1 389 ? -8.529  -30.749 -42.060 1.00 38.89  ? 652  ARG A C   1 
ATOM   2808 O  O   . ARG A 1 389 ? -8.905  -31.684 -41.361 1.00 43.05  ? 652  ARG A O   1 
ATOM   2809 C  CB  . ARG A 1 389 ? -10.411 -29.339 -43.095 1.00 38.25  ? 652  ARG A CB  1 
ATOM   2810 C  CG  . ARG A 1 389 ? -11.347 -28.161 -42.881 1.00 41.30  ? 652  ARG A CG  1 
ATOM   2811 C  CD  . ARG A 1 389 ? -12.465 -28.011 -43.908 1.00 42.55  ? 652  ARG A CD  1 
ATOM   2812 N  NE  . ARG A 1 389 ? -13.293 -29.195 -43.958 1.00 46.43  ? 652  ARG A NE  1 
ATOM   2813 C  CZ  . ARG A 1 389 ? -14.376 -29.398 -43.217 1.00 44.25  ? 652  ARG A CZ  1 
ATOM   2814 N  NH1 . ARG A 1 389 ? -14.804 -28.482 -42.359 1.00 43.34  ? 652  ARG A NH1 1 
ATOM   2815 N  NH2 . ARG A 1 389 ? -14.971 -30.574 -43.290 1.00 47.28  ? 652  ARG A NH2 1 
ATOM   2816 N  N   . GLU A 1 390 ? -7.500  -30.844 -42.901 1.00 34.96  ? 653  GLU A N   1 
ATOM   2817 C  CA  . GLU A 1 390 ? -6.708  -32.106 -42.997 1.00 38.06  ? 653  GLU A CA  1 
ATOM   2818 C  C   . GLU A 1 390 ? -6.021  -32.357 -41.639 1.00 34.78  ? 653  GLU A C   1 
ATOM   2819 O  O   . GLU A 1 390 ? -5.981  -33.506 -41.241 1.00 36.25  ? 653  GLU A O   1 
ATOM   2820 C  CB  . GLU A 1 390 ? -5.676  -32.088 -44.136 1.00 37.76  ? 653  GLU A CB  1 
ATOM   2821 C  CG  . GLU A 1 390 ? -5.108  -33.467 -44.437 1.00 37.97  ? 653  GLU A CG  1 
ATOM   2822 C  CD  . GLU A 1 390 ? -3.955  -34.008 -43.568 1.00 41.82  ? 653  GLU A CD  1 
ATOM   2823 O  OE1 . GLU A 1 390 ? -3.362  -33.264 -42.724 1.00 38.26  ? 653  GLU A OE1 1 
ATOM   2824 O  OE2 . GLU A 1 390 ? -3.649  -35.193 -43.710 1.00 46.33  ? 653  GLU A OE2 1 
ATOM   2825 N  N   . ARG A 1 391 ? -5.561  -31.319 -40.935 1.00 33.24  ? 654  ARG A N   1 
ATOM   2826 C  CA  . ARG A 1 391 ? -4.773  -31.477 -39.687 1.00 36.02  ? 654  ARG A CA  1 
ATOM   2827 C  C   . ARG A 1 391 ? -5.707  -31.776 -38.499 1.00 34.36  ? 654  ARG A C   1 
ATOM   2828 O  O   . ARG A 1 391 ? -5.235  -32.398 -37.518 1.00 32.91  ? 654  ARG A O   1 
ATOM   2829 C  CB  . ARG A 1 391 ? -3.959  -30.212 -39.409 1.00 36.09  ? 654  ARG A CB  1 
ATOM   2830 C  CG  . ARG A 1 391 ? -2.937  -29.868 -40.486 1.00 39.20  ? 654  ARG A CG  1 
ATOM   2831 C  CD  . ARG A 1 391 ? -1.833  -30.897 -40.633 1.00 42.54  ? 654  ARG A CD  1 
ATOM   2832 N  NE  . ARG A 1 391 ? -0.755  -30.453 -41.516 1.00 41.92  ? 654  ARG A NE  1 
ATOM   2833 C  CZ  . ARG A 1 391 ? -0.663  -30.666 -42.829 1.00 40.43  ? 654  ARG A CZ  1 
ATOM   2834 N  NH1 . ARG A 1 391 ? -1.569  -31.346 -43.494 1.00 42.66  ? 654  ARG A NH1 1 
ATOM   2835 N  NH2 . ARG A 1 391 ? 0.378   -30.209 -43.494 1.00 48.85  ? 654  ARG A NH2 1 
ATOM   2836 N  N   . LEU A 1 392 ? -6.954  -31.286 -38.534 1.00 31.80  ? 655  LEU A N   1 
ATOM   2837 C  CA  . LEU A 1 392 ? -8.006  -31.642 -37.519 1.00 33.06  ? 655  LEU A CA  1 
ATOM   2838 C  C   . LEU A 1 392 ? -8.294  -33.151 -37.625 1.00 33.16  ? 655  LEU A C   1 
ATOM   2839 O  O   . LEU A 1 392 ? -8.446  -33.805 -36.571 1.00 31.07  ? 655  LEU A O   1 
ATOM   2840 C  CB  . LEU A 1 392 ? -9.289  -30.815 -37.705 1.00 36.10  ? 655  LEU A CB  1 
ATOM   2841 C  CG  . LEU A 1 392 ? -9.244  -29.325 -37.340 1.00 33.53  ? 655  LEU A CG  1 
ATOM   2842 C  CD1 . LEU A 1 392 ? -10.559 -28.635 -37.724 1.00 36.56  ? 655  LEU A CD1 1 
ATOM   2843 C  CD2 . LEU A 1 392 ? -8.932  -29.105 -35.866 1.00 32.87  ? 655  LEU A CD2 1 
ATOM   2844 N  N   . SER A 1 393 ? -8.317  -33.707 -38.837 1.00 32.61  ? 656  SER A N   1 
ATOM   2845 C  CA  . SER A 1 393 ? -8.648  -35.130 -39.082 1.00 34.92  ? 656  SER A CA  1 
ATOM   2846 C  C   . SER A 1 393 ? -7.501  -36.034 -38.637 1.00 36.26  ? 656  SER A C   1 
ATOM   2847 O  O   . SER A 1 393 ? -7.725  -37.247 -38.627 1.00 34.65  ? 656  SER A O   1 
ATOM   2848 C  CB  . SER A 1 393 ? -8.984  -35.381 -40.540 1.00 39.14  ? 656  SER A CB  1 
ATOM   2849 O  OG  . SER A 1 393 ? -7.822  -35.227 -41.359 1.00 45.49  ? 656  SER A OG  1 
ATOM   2850 N  N   . ARG A 1 394 ? -6.332  -35.472 -38.296 1.00 35.38  ? 657  ARG A N   1 
ATOM   2851 C  CA  . ARG A 1 394 ? -5.152  -36.224 -37.789 1.00 34.34  ? 657  ARG A CA  1 
ATOM   2852 C  C   . ARG A 1 394 ? -5.252  -36.381 -36.275 1.00 33.68  ? 657  ARG A C   1 
ATOM   2853 O  O   . ARG A 1 394 ? -4.297  -36.919 -35.652 1.00 29.93  ? 657  ARG A O   1 
ATOM   2854 C  CB  . ARG A 1 394 ? -3.850  -35.457 -38.058 1.00 36.53  ? 657  ARG A CB  1 
ATOM   2855 C  CG  . ARG A 1 394 ? -3.432  -35.562 -39.509 1.00 36.26  ? 657  ARG A CG  1 
ATOM   2856 C  CD  . ARG A 1 394 ? -2.284  -34.655 -39.856 1.00 36.11  ? 657  ARG A CD  1 
ATOM   2857 N  NE  . ARG A 1 394 ? -1.880  -35.162 -41.144 1.00 37.54  ? 657  ARG A NE  1 
ATOM   2858 C  CZ  . ARG A 1 394 ? -1.094  -36.205 -41.315 1.00 40.69  ? 657  ARG A CZ  1 
ATOM   2859 N  NH1 . ARG A 1 394 ? -0.554  -36.820 -40.281 1.00 41.51  ? 657  ARG A NH1 1 
ATOM   2860 N  NH2 . ARG A 1 394 ? -0.827  -36.645 -42.526 1.00 45.67  ? 657  ARG A NH2 1 
ATOM   2861 N  N   . MET A 1 395 ? -6.329  -35.874 -35.691 1.00 29.84  ? 658  MET A N   1 
ATOM   2862 C  CA  . MET A 1 395 ? -6.526  -35.872 -34.216 1.00 29.78  ? 658  MET A CA  1 
ATOM   2863 C  C   . MET A 1 395 ? -7.835  -36.570 -33.796 1.00 31.10  ? 658  MET A C   1 
ATOM   2864 O  O   . MET A 1 395 ? -8.804  -36.584 -34.554 1.00 28.99  ? 658  MET A O   1 
ATOM   2865 C  CB  . MET A 1 395 ? -6.510  -34.424 -33.753 1.00 30.85  ? 658  MET A CB  1 
ATOM   2866 C  CG  . MET A 1 395 ? -5.318  -33.652 -34.332 1.00 33.92  ? 658  MET A CG  1 
ATOM   2867 S  SD  . MET A 1 395 ? -4.917  -32.181 -33.372 1.00 35.11  ? 658  MET A SD  1 
ATOM   2868 C  CE  . MET A 1 395 ? -6.131  -31.035 -33.999 1.00 35.58  ? 658  MET A CE  1 
ATOM   2869 N  N   . ALA A 1 396 ? -7.833  -37.135 -32.604 1.00 30.73  ? 659  ALA A N   1 
ATOM   2870 C  CA  . ALA A 1 396 ? -9.029  -37.579 -31.876 1.00 33.68  ? 659  ALA A CA  1 
ATOM   2871 C  C   . ALA A 1 396 ? -8.984  -36.875 -30.516 1.00 30.22  ? 659  ALA A C   1 
ATOM   2872 O  O   . ALA A 1 396 ? -8.003  -37.072 -29.829 1.00 27.56  ? 659  ALA A O   1 
ATOM   2873 C  CB  . ALA A 1 396 ? -9.037  -39.088 -31.780 1.00 34.51  ? 659  ALA A CB  1 
ATOM   2874 N  N   . ILE A 1 397 ? -9.969  -36.025 -30.197 1.00 28.25  ? 660  ILE A N   1 
ATOM   2875 C  CA  . ILE A 1 397 ? -9.912  -35.123 -29.021 1.00 26.66  ? 660  ILE A CA  1 
ATOM   2876 C  C   . ILE A 1 397 ? -11.219 -35.220 -28.245 1.00 31.72  ? 660  ILE A C   1 
ATOM   2877 O  O   . ILE A 1 397 ? -12.289 -35.098 -28.843 1.00 32.64  ? 660  ILE A O   1 
ATOM   2878 C  CB  . ILE A 1 397 ? -9.588  -33.699 -29.467 1.00 30.12  ? 660  ILE A CB  1 
ATOM   2879 C  CG1 . ILE A 1 397 ? -8.280  -33.710 -30.267 1.00 35.32  ? 660  ILE A CG1 1 
ATOM   2880 C  CG2 . ILE A 1 397 ? -9.590  -32.779 -28.281 1.00 32.85  ? 660  ILE A CG2 1 
ATOM   2881 C  CD1 . ILE A 1 397 ? -7.580  -32.395 -30.468 1.00 38.24  ? 660  ILE A CD1 1 
ATOM   2882 N  N   . SER A 1 398 ? -11.098 -35.471 -26.942 1.00 29.76  ? 661  SER A N   1 
ATOM   2883 C  CA  . SER A 1 398 ? -12.213 -35.661 -26.013 1.00 31.88  ? 661  SER A CA  1 
ATOM   2884 C  C   . SER A 1 398 ? -11.867 -34.846 -24.781 1.00 32.72  ? 661  SER A C   1 
ATOM   2885 O  O   . SER A 1 398 ? -11.117 -35.343 -23.917 1.00 32.21  ? 661  SER A O   1 
ATOM   2886 C  CB  . SER A 1 398 ? -12.484 -37.136 -25.707 1.00 32.54  ? 661  SER A CB  1 
ATOM   2887 O  OG  . SER A 1 398 ? -13.806 -37.330 -25.196 1.00 32.72  ? 661  SER A OG  1 
ATOM   2888 N  N   . GLY A 1 399 ? -12.384 -33.628 -24.707 1.00 30.75  ? 662  GLY A N   1 
ATOM   2889 C  CA  . GLY A 1 399 ? -12.044 -32.781 -23.556 1.00 32.35  ? 662  GLY A CA  1 
ATOM   2890 C  C   . GLY A 1 399 ? -10.544 -32.593 -23.496 1.00 32.56  ? 662  GLY A C   1 
ATOM   2891 O  O   . GLY A 1 399 ? -9.913  -32.300 -24.549 1.00 30.54  ? 662  GLY A O   1 
ATOM   2892 N  N   . ASP A 1 400 ? -9.963  -32.771 -22.319 1.00 34.50  ? 663  ASP A N   1 
ATOM   2893 C  CA  . ASP A 1 400 ? -8.510  -32.560 -22.089 1.00 37.21  ? 663  ASP A CA  1 
ATOM   2894 C  C   . ASP A 1 400 ? -7.682  -33.712 -22.684 1.00 36.11  ? 663  ASP A C   1 
ATOM   2895 O  O   . ASP A 1 400 ? -6.460  -33.637 -22.669 1.00 37.47  ? 663  ASP A O   1 
ATOM   2896 C  CB  . ASP A 1 400 ? -8.255  -32.313 -20.604 1.00 41.78  ? 663  ASP A CB  1 
ATOM   2897 C  CG  . ASP A 1 400 ? -8.416  -33.535 -19.745 1.00 41.47  ? 663  ASP A CG  1 
ATOM   2898 O  OD1 . ASP A 1 400 ? -9.175  -34.433 -20.120 1.00 45.65  ? 663  ASP A OD1 1 
ATOM   2899 O  OD2 . ASP A 1 400 ? -7.776  -33.566 -18.705 1.00 62.14  ? 663  ASP A OD2 1 
ATOM   2900 N  N   . ASP A 1 401 ? -8.301  -34.713 -23.282 1.00 33.31  ? 664  ASP A N   1 
ATOM   2901 C  CA  . ASP A 1 401 ? -7.586  -35.918 -23.764 1.00 32.29  ? 664  ASP A CA  1 
ATOM   2902 C  C   . ASP A 1 401 ? -7.441  -35.875 -25.282 1.00 32.88  ? 664  ASP A C   1 
ATOM   2903 O  O   . ASP A 1 401 ? -8.416  -35.496 -25.962 1.00 33.11  ? 664  ASP A O   1 
ATOM   2904 C  CB  . ASP A 1 401 ? -8.367  -37.169 -23.376 1.00 34.26  ? 664  ASP A CB  1 
ATOM   2905 C  CG  . ASP A 1 401 ? -7.457  -38.364 -23.351 1.00 34.91  ? 664  ASP A CG  1 
ATOM   2906 O  OD1 . ASP A 1 401 ? -6.290  -38.128 -23.402 1.00 42.96  ? 664  ASP A OD1 1 
ATOM   2907 O  OD2 . ASP A 1 401 ? -7.926  -39.484 -23.277 1.00 38.42  ? 664  ASP A OD2 1 
ATOM   2908 N  N   . CYS A 1 402 ? -6.296  -36.280 -25.809 1.00 31.64  ? 665  CYS A N   1 
ATOM   2909 C  CA  . CYS A 1 402 ? -5.980  -36.166 -27.246 1.00 33.20  ? 665  CYS A CA  1 
ATOM   2910 C  C   . CYS A 1 402 ? -5.029  -37.267 -27.708 1.00 35.26  ? 665  CYS A C   1 
ATOM   2911 O  O   . CYS A 1 402 ? -4.214  -37.785 -26.897 1.00 33.51  ? 665  CYS A O   1 
ATOM   2912 C  CB  . CYS A 1 402 ? -5.378  -34.807 -27.584 1.00 38.36  ? 665  CYS A CB  1 
ATOM   2913 S  SG  . CYS A 1 402 ? -3.722  -34.524 -26.903 1.00 42.72  ? 665  CYS A SG  1 
ATOM   2914 N  N   . VAL A 1 403 ? -5.145  -37.560 -28.999 1.00 32.69  ? 666  VAL A N   1 
ATOM   2915 C  CA  . VAL A 1 403 ? -4.226  -38.419 -29.793 1.00 33.15  ? 666  VAL A CA  1 
ATOM   2916 C  C   . VAL A 1 403 ? -3.958  -37.657 -31.089 1.00 32.81  ? 666  VAL A C   1 
ATOM   2917 O  O   . VAL A 1 403 ? -4.937  -37.215 -31.741 1.00 34.08  ? 666  VAL A O   1 
ATOM   2918 C  CB  . VAL A 1 403 ? -4.840  -39.801 -30.044 1.00 33.45  ? 666  VAL A CB  1 
ATOM   2919 C  CG1 . VAL A 1 403 ? -3.958  -40.610 -30.955 1.00 33.76  ? 666  VAL A CG1 1 
ATOM   2920 C  CG2 . VAL A 1 403 ? -5.108  -40.524 -28.714 1.00 35.24  ? 666  VAL A CG2 1 
ATOM   2921 N  N   . VAL A 1 404 ? -2.695  -37.394 -31.385 1.00 31.35  ? 667  VAL A N   1 
ATOM   2922 C  CA  . VAL A 1 404 ? -2.296  -36.651 -32.611 1.00 32.48  ? 667  VAL A CA  1 
ATOM   2923 C  C   . VAL A 1 404 ? -1.367  -37.541 -33.419 1.00 31.45  ? 667  VAL A C   1 
ATOM   2924 O  O   . VAL A 1 404 ? -0.413  -38.112 -32.844 1.00 32.36  ? 667  VAL A O   1 
ATOM   2925 C  CB  . VAL A 1 404 ? -1.662  -35.293 -32.270 1.00 33.18  ? 667  VAL A CB  1 
ATOM   2926 C  CG1 . VAL A 1 404 ? -1.465  -34.455 -33.513 1.00 32.03  ? 667  VAL A CG1 1 
ATOM   2927 C  CG2 . VAL A 1 404 ? -2.493  -34.518 -31.254 1.00 34.20  ? 667  VAL A CG2 1 
ATOM   2928 N  N   . LYS A 1 405 ? -1.679  -37.692 -34.691 1.00 29.36  ? 668  LYS A N   1 
ATOM   2929 C  CA  . LYS A 1 405 ? -0.741  -38.219 -35.697 1.00 32.32  ? 668  LYS A CA  1 
ATOM   2930 C  C   . LYS A 1 405 ? -0.304  -37.080 -36.614 1.00 35.79  ? 668  LYS A C   1 
ATOM   2931 O  O   . LYS A 1 405 ? -0.898  -36.867 -37.680 1.00 31.51  ? 668  LYS A O   1 
ATOM   2932 C  CB  . LYS A 1 405 ? -1.311  -39.333 -36.556 1.00 34.12  ? 668  LYS A CB  1 
ATOM   2933 C  CG  . LYS A 1 405 ? -0.215  -39.948 -37.391 1.00 35.90  ? 668  LYS A CG  1 
ATOM   2934 C  CD  . LYS A 1 405 ? -0.542  -41.249 -38.014 1.00 40.14  ? 668  LYS A CD  1 
ATOM   2935 C  CE  . LYS A 1 405 ? 0.536   -41.554 -39.032 1.00 45.23  ? 668  LYS A CE  1 
ATOM   2936 N  NZ  . LYS A 1 405 ? 0.700   -42.999 -39.211 1.00 46.94  ? 668  LYS A NZ  1 
ATOM   2937 N  N   . PRO A 1 406 ? 0.777   -36.363 -36.224 1.00 33.48  ? 669  PRO A N   1 
ATOM   2938 C  CA  . PRO A 1 406 ? 1.281   -35.222 -36.981 1.00 35.48  ? 669  PRO A CA  1 
ATOM   2939 C  C   . PRO A 1 406 ? 1.941   -35.671 -38.289 1.00 31.92  ? 669  PRO A C   1 
ATOM   2940 O  O   . PRO A 1 406 ? 2.163   -36.859 -38.510 1.00 34.42  ? 669  PRO A O   1 
ATOM   2941 C  CB  . PRO A 1 406 ? 2.280   -34.565 -36.020 1.00 33.49  ? 669  PRO A CB  1 
ATOM   2942 C  CG  . PRO A 1 406 ? 2.800   -35.744 -35.247 1.00 37.69  ? 669  PRO A CG  1 
ATOM   2943 C  CD  . PRO A 1 406 ? 1.609   -36.654 -35.053 1.00 34.85  ? 669  PRO A CD  1 
ATOM   2944 N  N   . LEU A 1 407 ? 2.236   -34.706 -39.134 1.00 33.82  ? 670  LEU A N   1 
ATOM   2945 C  CA  . LEU A 1 407 ? 2.899   -34.927 -40.449 1.00 38.58  ? 670  LEU A CA  1 
ATOM   2946 C  C   . LEU A 1 407 ? 4.238   -35.692 -40.285 1.00 41.00  ? 670  LEU A C   1 
ATOM   2947 O  O   . LEU A 1 407 ? 4.616   -36.497 -41.176 1.00 38.39  ? 670  LEU A O   1 
ATOM   2948 C  CB  . LEU A 1 407 ? 3.086   -33.531 -41.026 1.00 40.80  ? 670  LEU A CB  1 
ATOM   2949 C  CG  . LEU A 1 407 ? 3.254   -33.477 -42.528 1.00 52.43  ? 670  LEU A CG  1 
ATOM   2950 C  CD1 . LEU A 1 407 ? 1.972   -33.956 -43.203 1.00 52.60  ? 670  LEU A CD1 1 
ATOM   2951 C  CD2 . LEU A 1 407 ? 3.648   -32.055 -42.943 1.00 53.15  ? 670  LEU A CD2 1 
ATOM   2952 N  N   . ASP A 1 408 ? 4.934   -35.489 -39.168 1.00 37.54  ? 671  ASP A N   1 
ATOM   2953 C  CA  . ASP A 1 408 ? 6.251   -36.133 -38.915 1.00 47.10  ? 671  ASP A CA  1 
ATOM   2954 C  C   . ASP A 1 408 ? 6.633   -35.892 -37.456 1.00 45.30  ? 671  ASP A C   1 
ATOM   2955 O  O   . ASP A 1 408 ? 5.881   -35.208 -36.753 1.00 43.54  ? 671  ASP A O   1 
ATOM   2956 C  CB  . ASP A 1 408 ? 7.313   -35.604 -39.894 1.00 45.78  ? 671  ASP A CB  1 
ATOM   2957 C  CG  . ASP A 1 408 ? 7.369   -34.093 -39.893 1.00 44.47  ? 671  ASP A CG  1 
ATOM   2958 O  OD1 . ASP A 1 408 ? 7.737   -33.536 -38.822 1.00 43.22  ? 671  ASP A OD1 1 
ATOM   2959 O  OD2 . ASP A 1 408 ? 6.978   -33.484 -40.934 1.00 41.83  ? 671  ASP A OD2 1 
ATOM   2960 N  N   . ASP A 1 409 ? 7.781   -36.403 -37.029 1.00 48.58  ? 672  ASP A N   1 
ATOM   2961 C  CA  . ASP A 1 409 ? 8.110   -36.495 -35.583 1.00 44.88  ? 672  ASP A CA  1 
ATOM   2962 C  C   . ASP A 1 409 ? 8.771   -35.215 -35.063 1.00 39.80  ? 672  ASP A C   1 
ATOM   2963 O  O   . ASP A 1 409 ? 9.068   -35.214 -33.865 1.00 41.12  ? 672  ASP A O   1 
ATOM   2964 C  CB  . ASP A 1 409 ? 8.906   -37.764 -35.310 1.00 45.70  ? 672  ASP A CB  1 
ATOM   2965 C  CG  . ASP A 1 409 ? 8.050   -39.003 -35.488 1.00 47.21  ? 672  ASP A CG  1 
ATOM   2966 O  OD1 . ASP A 1 409 ? 6.923   -38.998 -34.965 1.00 43.26  ? 672  ASP A OD1 1 
ATOM   2967 O  OD2 . ASP A 1 409 ? 8.507   -39.952 -36.179 1.00 49.31  ? 672  ASP A OD2 1 
ATOM   2968 N  N   . ARG A 1 410 ? 8.867   -34.138 -35.861 1.00 36.37  ? 673  ARG A N   1 
ATOM   2969 C  CA  . ARG A 1 410 ? 9.294   -32.798 -35.358 1.00 38.45  ? 673  ARG A CA  1 
ATOM   2970 C  C   . ARG A 1 410 ? 8.292   -32.318 -34.299 1.00 36.36  ? 673  ARG A C   1 
ATOM   2971 O  O   . ARG A 1 410 ? 8.650   -31.480 -33.443 1.00 38.52  ? 673  ARG A O   1 
ATOM   2972 C  CB  . ARG A 1 410 ? 9.332   -31.716 -36.459 1.00 43.81  ? 673  ARG A CB  1 
ATOM   2973 C  CG  . ARG A 1 410 ? 10.297  -31.974 -37.613 1.00 43.65  ? 673  ARG A CG  1 
ATOM   2974 C  CD  . ARG A 1 410 ? 10.141  -30.923 -38.698 1.00 43.97  ? 673  ARG A CD  1 
ATOM   2975 N  NE  . ARG A 1 410 ? 8.987   -31.223 -39.530 1.00 46.32  ? 673  ARG A NE  1 
ATOM   2976 C  CZ  . ARG A 1 410 ? 8.507   -30.444 -40.494 1.00 48.73  ? 673  ARG A CZ  1 
ATOM   2977 N  NH1 . ARG A 1 410 ? 9.078   -29.284 -40.746 1.00 45.07  ? 673  ARG A NH1 1 
ATOM   2978 N  NH2 . ARG A 1 410 ? 7.435   -30.813 -41.186 1.00 48.28  ? 673  ARG A NH2 1 
ATOM   2979 N  N   . PHE A 1 411 ? 7.028   -32.735 -34.412 1.00 36.56  ? 674  PHE A N   1 
ATOM   2980 C  CA  . PHE A 1 411 ? 5.967   -32.431 -33.419 1.00 31.66  ? 674  PHE A CA  1 
ATOM   2981 C  C   . PHE A 1 411 ? 6.483   -32.720 -31.994 1.00 32.36  ? 674  PHE A C   1 
ATOM   2982 O  O   . PHE A 1 411 ? 6.172   -31.954 -31.090 1.00 34.73  ? 674  PHE A O   1 
ATOM   2983 C  CB  . PHE A 1 411 ? 4.753   -33.295 -33.756 1.00 36.15  ? 674  PHE A CB  1 
ATOM   2984 C  CG  . PHE A 1 411 ? 3.578   -33.158 -32.832 1.00 32.77  ? 674  PHE A CG  1 
ATOM   2985 C  CD1 . PHE A 1 411 ? 3.484   -33.935 -31.689 1.00 34.04  ? 674  PHE A CD1 1 
ATOM   2986 C  CD2 . PHE A 1 411 ? 2.558   -32.269 -33.123 1.00 39.20  ? 674  PHE A CD2 1 
ATOM   2987 C  CE1 . PHE A 1 411 ? 2.366   -33.842 -30.870 1.00 33.98  ? 674  PHE A CE1 1 
ATOM   2988 C  CE2 . PHE A 1 411 ? 1.441   -32.165 -32.299 1.00 36.18  ? 674  PHE A CE2 1 
ATOM   2989 C  CZ  . PHE A 1 411 ? 1.356   -32.940 -31.162 1.00 34.76  ? 674  PHE A CZ  1 
ATOM   2990 N  N   . ALA A 1 412 ? 7.257   -33.799 -31.822 1.00 32.67  ? 675  ALA A N   1 
ATOM   2991 C  CA  . ALA A 1 412 ? 7.724   -34.367 -30.534 1.00 32.82  ? 675  ALA A CA  1 
ATOM   2992 C  C   . ALA A 1 412 ? 8.502   -33.331 -29.703 1.00 35.58  ? 675  ALA A C   1 
ATOM   2993 O  O   . ALA A 1 412 ? 8.279   -33.252 -28.474 1.00 36.21  ? 675  ALA A O   1 
ATOM   2994 C  CB  . ALA A 1 412 ? 8.527   -35.622 -30.823 1.00 32.44  ? 675  ALA A CB  1 
ATOM   2995 N  N   . SER A 1 413 ? 9.341   -32.510 -30.343 1.00 41.58  ? 676  SER A N   1 
ATOM   2996 C  CA  . SER A 1 413 ? 10.131  -31.435 -29.686 1.00 41.63  ? 676  SER A CA  1 
ATOM   2997 C  C   . SER A 1 413 ? 9.534   -30.040 -29.916 1.00 44.53  ? 676  SER A C   1 
ATOM   2998 O  O   . SER A 1 413 ? 10.119  -29.101 -29.398 1.00 51.45  ? 676  SER A O   1 
ATOM   2999 C  CB  . SER A 1 413 ? 11.601  -31.509 -30.088 1.00 46.13  ? 676  SER A CB  1 
ATOM   3000 O  OG  . SER A 1 413 ? 11.735  -31.969 -31.415 1.00 49.89  ? 676  SER A OG  1 
ATOM   3001 N  N   . ALA A 1 414 ? 8.358   -29.880 -30.541 1.00 45.61  ? 677  ALA A N   1 
ATOM   3002 C  CA  . ALA A 1 414 ? 7.692   -28.556 -30.666 1.00 41.34  ? 677  ALA A CA  1 
ATOM   3003 C  C   . ALA A 1 414 ? 6.933   -28.245 -29.374 1.00 46.33  ? 677  ALA A C   1 
ATOM   3004 O  O   . ALA A 1 414 ? 5.741   -28.628 -29.270 1.00 48.34  ? 677  ALA A O   1 
ATOM   3005 C  CB  . ALA A 1 414 ? 6.773   -28.541 -31.858 1.00 45.12  ? 677  ALA A CB  1 
ATOM   3006 N  N   . LEU A 1 415 ? 7.583   -27.576 -28.425 1.00 41.17  ? 678  LEU A N   1 
ATOM   3007 C  CA  . LEU A 1 415 ? 7.103   -27.477 -27.024 1.00 42.08  ? 678  LEU A CA  1 
ATOM   3008 C  C   . LEU A 1 415 ? 6.917   -26.021 -26.589 1.00 42.36  ? 678  LEU A C   1 
ATOM   3009 O  O   . LEU A 1 415 ? 6.278   -25.822 -25.529 1.00 44.70  ? 678  LEU A O   1 
ATOM   3010 C  CB  . LEU A 1 415 ? 8.094   -28.200 -26.106 1.00 42.83  ? 678  LEU A CB  1 
ATOM   3011 C  CG  . LEU A 1 415 ? 8.213   -29.720 -26.311 1.00 49.39  ? 678  LEU A CG  1 
ATOM   3012 C  CD1 . LEU A 1 415 ? 9.283   -30.350 -25.412 1.00 47.02  ? 678  LEU A CD1 1 
ATOM   3013 C  CD2 . LEU A 1 415 ? 6.886   -30.412 -26.062 1.00 50.66  ? 678  LEU A CD2 1 
ATOM   3014 N  N   . THR A 1 416 ? 7.418   -25.030 -27.337 1.00 40.98  ? 679  THR A N   1 
ATOM   3015 C  CA  . THR A 1 416 ? 7.472   -23.639 -26.810 1.00 41.41  ? 679  THR A CA  1 
ATOM   3016 C  C   . THR A 1 416 ? 6.039   -23.120 -26.680 1.00 44.43  ? 679  THR A C   1 
ATOM   3017 O  O   . THR A 1 416 ? 5.661   -22.680 -25.585 1.00 45.96  ? 679  THR A O   1 
ATOM   3018 C  CB  . THR A 1 416 ? 8.356   -22.724 -27.665 1.00 46.69  ? 679  THR A CB  1 
ATOM   3019 O  OG1 . THR A 1 416 ? 7.791   -22.539 -28.965 1.00 44.31  ? 679  THR A OG1 1 
ATOM   3020 C  CG2 . THR A 1 416 ? 9.762   -23.265 -27.819 1.00 48.43  ? 679  THR A CG2 1 
ATOM   3021 N  N   . ALA A 1 417 ? 5.246   -23.203 -27.752 1.00 44.53  ? 680  ALA A N   1 
ATOM   3022 C  CA  . ALA A 1 417 ? 3.843   -22.714 -27.754 1.00 40.46  ? 680  ALA A CA  1 
ATOM   3023 C  C   . ALA A 1 417 ? 3.027   -23.487 -26.711 1.00 39.84  ? 680  ALA A C   1 
ATOM   3024 O  O   . ALA A 1 417 ? 2.288   -22.838 -25.917 1.00 36.99  ? 680  ALA A O   1 
ATOM   3025 C  CB  . ALA A 1 417 ? 3.256   -22.808 -29.141 1.00 44.06  ? 680  ALA A CB  1 
ATOM   3026 N  N   . LEU A 1 418 ? 3.187   -24.820 -26.651 1.00 40.89  ? 681  LEU A N   1 
ATOM   3027 C  CA  . LEU A 1 418 ? 2.383   -25.653 -25.727 1.00 36.51  ? 681  LEU A CA  1 
ATOM   3028 C  C   . LEU A 1 418 ? 2.674   -25.286 -24.266 1.00 43.55  ? 681  LEU A C   1 
ATOM   3029 O  O   . LEU A 1 418 ? 1.707   -25.127 -23.501 1.00 44.62  ? 681  LEU A O   1 
ATOM   3030 C  CB  . LEU A 1 418 ? 2.695   -27.110 -25.998 1.00 38.80  ? 681  LEU A CB  1 
ATOM   3031 C  CG  . LEU A 1 418 ? 1.894   -28.092 -25.153 1.00 41.65  ? 681  LEU A CG  1 
ATOM   3032 C  CD1 . LEU A 1 418 ? 0.443   -28.167 -25.635 1.00 38.86  ? 681  LEU A CD1 1 
ATOM   3033 C  CD2 . LEU A 1 418 ? 2.559   -29.453 -25.199 1.00 38.66  ? 681  LEU A CD2 1 
ATOM   3034 N  N   . ASN A 1 419 ? 3.954   -25.166 -23.879 1.00 45.29  ? 682  ASN A N   1 
ATOM   3035 C  CA  . ASN A 1 419 ? 4.327   -24.792 -22.493 1.00 43.56  ? 682  ASN A CA  1 
ATOM   3036 C  C   . ASN A 1 419 ? 3.907   -23.335 -22.244 1.00 43.23  ? 682  ASN A C   1 
ATOM   3037 O  O   . ASN A 1 419 ? 3.311   -23.070 -21.186 1.00 45.54  ? 682  ASN A O   1 
ATOM   3038 C  CB  . ASN A 1 419 ? 5.813   -24.999 -22.230 1.00 45.41  ? 682  ASN A CB  1 
ATOM   3039 C  CG  . ASN A 1 419 ? 6.198   -26.456 -22.080 1.00 47.14  ? 682  ASN A CG  1 
ATOM   3040 O  OD1 . ASN A 1 419 ? 5.486   -27.225 -21.431 1.00 51.84  ? 682  ASN A OD1 1 
ATOM   3041 N  ND2 . ASN A 1 419 ? 7.342   -26.834 -22.634 1.00 43.71  ? 682  ASN A ND2 1 
ATOM   3042 N  N   . ASP A 1 420 ? 4.134   -22.431 -23.197 1.00 39.85  ? 683  ASP A N   1 
ATOM   3043 C  CA  . ASP A 1 420 ? 3.777   -20.994 -23.035 1.00 45.62  ? 683  ASP A CA  1 
ATOM   3044 C  C   . ASP A 1 420 ? 2.242   -20.805 -23.000 1.00 49.45  ? 683  ASP A C   1 
ATOM   3045 O  O   . ASP A 1 420 ? 1.824   -19.787 -22.400 1.00 47.26  ? 683  ASP A O   1 
ATOM   3046 C  CB  . ASP A 1 420 ? 4.417   -20.087 -24.100 1.00 44.68  ? 683  ASP A CB  1 
ATOM   3047 C  CG  . ASP A 1 420 ? 4.191   -18.601 -23.824 1.00 52.70  ? 683  ASP A CG  1 
ATOM   3048 O  OD1 . ASP A 1 420 ? 4.411   -18.174 -22.650 1.00 47.15  ? 683  ASP A OD1 1 
ATOM   3049 O  OD2 . ASP A 1 420 ? 3.755   -17.871 -24.771 1.00 51.49  ? 683  ASP A OD2 1 
ATOM   3050 N  N   . MET A 1 421 ? 1.414   -21.718 -23.556 1.00 46.50  ? 684  MET A N   1 
ATOM   3051 C  CA  . MET A 1 421 ? -0.076  -21.638 -23.377 1.00 41.24  ? 684  MET A CA  1 
ATOM   3052 C  C   . MET A 1 421 ? -0.451  -22.141 -21.974 1.00 40.85  ? 684  MET A C   1 
ATOM   3053 O  O   . MET A 1 421 ? -1.620  -22.011 -21.583 1.00 44.99  ? 684  MET A O   1 
ATOM   3054 C  CB  . MET A 1 421 ? -0.830  -22.441 -24.438 1.00 46.72  ? 684  MET A CB  1 
ATOM   3055 C  CG  . MET A 1 421 ? -0.657  -21.882 -25.857 1.00 47.19  ? 684  MET A CG  1 
ATOM   3056 S  SD  . MET A 1 421 ? -1.574  -22.787 -27.162 1.00 51.79  ? 684  MET A SD  1 
ATOM   3057 C  CE  . MET A 1 421 ? -0.604  -24.273 -27.384 1.00 55.91  ? 684  MET A CE  1 
ATOM   3058 N  N   . GLY A 1 422 ? 0.510   -22.715 -21.236 1.00 42.34  ? 685  GLY A N   1 
ATOM   3059 C  CA  . GLY A 1 422 ? 0.303   -23.237 -19.868 1.00 38.76  ? 685  GLY A CA  1 
ATOM   3060 C  C   . GLY A 1 422 ? -0.165  -24.677 -19.856 1.00 38.73  ? 685  GLY A C   1 
ATOM   3061 O  O   . GLY A 1 422 ? -0.451  -25.153 -18.756 1.00 40.36  ? 685  GLY A O   1 
ATOM   3062 N  N   . LYS A 1 423 ? -0.239  -25.333 -21.029 1.00 38.64  ? 686  LYS A N   1 
ATOM   3063 C  CA  . LYS A 1 423 ? -0.687  -26.751 -21.203 1.00 44.89  ? 686  LYS A CA  1 
ATOM   3064 C  C   . LYS A 1 423 ? 0.512   -27.706 -21.040 1.00 44.59  ? 686  LYS A C   1 
ATOM   3065 O  O   . LYS A 1 423 ? 0.847   -28.467 -21.962 1.00 42.03  ? 686  LYS A O   1 
ATOM   3066 C  CB  . LYS A 1 423 ? -1.448  -26.889 -22.527 1.00 42.75  ? 686  LYS A CB  1 
ATOM   3067 C  CG  . LYS A 1 423 ? -2.612  -25.911 -22.642 1.00 42.84  ? 686  LYS A CG  1 
ATOM   3068 C  CD  . LYS A 1 423 ? -3.546  -25.995 -21.451 1.00 44.03  ? 686  LYS A CD  1 
ATOM   3069 C  CE  . LYS A 1 423 ? -4.739  -25.077 -21.564 1.00 47.40  ? 686  LYS A CE  1 
ATOM   3070 N  NZ  . LYS A 1 423 ? -4.363  -23.655 -21.421 1.00 50.16  ? 686  LYS A NZ  1 
ATOM   3071 N  N   . VAL A 1 424 ? 1.080   -27.692 -19.839 1.00 45.53  ? 687  VAL A N   1 
ATOM   3072 C  CA  . VAL A 1 424 ? 2.338   -28.394 -19.483 1.00 47.33  ? 687  VAL A CA  1 
ATOM   3073 C  C   . VAL A 1 424 ? 2.031   -29.889 -19.439 1.00 41.97  ? 687  VAL A C   1 
ATOM   3074 O  O   . VAL A 1 424 ? 1.030   -30.249 -18.799 1.00 42.38  ? 687  VAL A O   1 
ATOM   3075 C  CB  . VAL A 1 424 ? 2.866   -27.848 -18.139 1.00 50.35  ? 687  VAL A CB  1 
ATOM   3076 C  CG1 . VAL A 1 424 ? 3.834   -28.802 -17.449 1.00 50.15  ? 687  VAL A CG1 1 
ATOM   3077 C  CG2 . VAL A 1 424 ? 3.504   -26.481 -18.351 1.00 50.19  ? 687  VAL A CG2 1 
ATOM   3078 N  N   . ARG A 1 425 ? 2.866   -30.720 -20.069 1.00 39.45  ? 688  ARG A N   1 
ATOM   3079 C  CA  . ARG A 1 425 ? 2.595   -32.176 -20.151 1.00 40.53  ? 688  ARG A CA  1 
ATOM   3080 C  C   . ARG A 1 425 ? 2.820   -32.804 -18.764 1.00 46.73  ? 688  ARG A C   1 
ATOM   3081 O  O   . ARG A 1 425 ? 3.696   -32.313 -18.002 1.00 48.53  ? 688  ARG A O   1 
ATOM   3082 C  CB  . ARG A 1 425 ? 3.438   -32.814 -21.249 1.00 38.92  ? 688  ARG A CB  1 
ATOM   3083 C  CG  . ARG A 1 425 ? 3.197   -32.242 -22.634 1.00 38.84  ? 688  ARG A CG  1 
ATOM   3084 C  CD  . ARG A 1 425 ? 4.356   -32.571 -23.538 1.00 42.30  ? 688  ARG A CD  1 
ATOM   3085 N  NE  . ARG A 1 425 ? 5.617   -32.005 -23.022 1.00 46.40  ? 688  ARG A NE  1 
ATOM   3086 C  CZ  . ARG A 1 425 ? 6.855   -32.455 -23.321 1.00 47.99  ? 688  ARG A CZ  1 
ATOM   3087 N  NH1 . ARG A 1 425 ? 7.052   -33.470 -24.167 1.00 40.61  ? 688  ARG A NH1 1 
ATOM   3088 N  NH2 . ARG A 1 425 ? 7.904   -31.867 -22.762 1.00 47.06  ? 688  ARG A NH2 1 
ATOM   3089 N  N   . LYS A 1 426 ? 2.044   -33.847 -18.451 0.46 45.71  ? 689  LYS A N   1 
ATOM   3090 C  CA  . LYS A 1 426 ? 2.127   -34.631 -17.192 0.46 47.58  ? 689  LYS A CA  1 
ATOM   3091 C  C   . LYS A 1 426 ? 3.296   -35.625 -17.284 0.46 51.94  ? 689  LYS A C   1 
ATOM   3092 O  O   . LYS A 1 426 ? 3.538   -36.149 -18.396 0.46 53.58  ? 689  LYS A O   1 
ATOM   3093 C  CB  . LYS A 1 426 ? 0.806   -35.370 -16.965 0.46 48.83  ? 689  LYS A CB  1 
ATOM   3094 C  CG  . LYS A 1 426 ? 0.643   -36.001 -15.590 0.46 50.35  ? 689  LYS A CG  1 
ATOM   3095 C  CD  . LYS A 1 426 ? -0.622  -36.823 -15.462 0.46 50.66  ? 689  LYS A CD  1 
ATOM   3096 C  CE  . LYS A 1 426 ? -1.090  -37.369 -16.795 0.46 51.57  ? 689  LYS A CE  1 
ATOM   3097 N  NZ  . LYS A 1 426 ? -1.436  -38.811 -16.731 0.46 51.15  ? 689  LYS A NZ  1 
ATOM   3098 N  N   . ASP A 1 427 ? 3.993   -35.863 -16.164 1.00 50.79  ? 690  ASP A N   1 
ATOM   3099 C  CA  . ASP A 1 427 ? 5.032   -36.930 -16.045 1.00 53.71  ? 690  ASP A CA  1 
ATOM   3100 C  C   . ASP A 1 427 ? 6.066   -36.928 -17.188 1.00 56.73  ? 690  ASP A C   1 
ATOM   3101 O  O   . ASP A 1 427 ? 6.164   -37.963 -17.906 1.00 56.94  ? 690  ASP A O   1 
ATOM   3102 C  CB  . ASP A 1 427 ? 4.352   -38.297 -16.009 1.00 57.47  ? 690  ASP A CB  1 
ATOM   3103 C  CG  . ASP A 1 427 ? 3.482   -38.479 -14.787 1.00 69.37  ? 690  ASP A CG  1 
ATOM   3104 O  OD1 . ASP A 1 427 ? 3.671   -37.686 -13.817 1.00 68.85  ? 690  ASP A OD1 1 
ATOM   3105 O  OD2 . ASP A 1 427 ? 2.619   -39.401 -14.822 1.00 72.36  ? 690  ASP A OD2 1 
ATOM   3106 N  N   . ILE A 1 428 ? 6.762   -35.807 -17.386 1.00 51.04  ? 691  ILE A N   1 
ATOM   3107 C  CA  . ILE A 1 428 ? 7.915   -35.654 -18.329 1.00 54.40  ? 691  ILE A CA  1 
ATOM   3108 C  C   . ILE A 1 428 ? 8.480   -34.253 -18.111 1.00 52.93  ? 691  ILE A C   1 
ATOM   3109 O  O   . ILE A 1 428 ? 7.705   -33.346 -17.833 1.00 58.85  ? 691  ILE A O   1 
ATOM   3110 C  CB  . ILE A 1 428 ? 7.511   -35.907 -19.798 1.00 55.32  ? 691  ILE A CB  1 
ATOM   3111 C  CG1 . ILE A 1 428 ? 8.716   -35.765 -20.728 1.00 57.86  ? 691  ILE A CG1 1 
ATOM   3112 C  CG2 . ILE A 1 428 ? 6.374   -34.999 -20.237 1.00 61.31  ? 691  ILE A CG2 1 
ATOM   3113 C  CD1 . ILE A 1 428 ? 8.583   -36.520 -22.023 1.00 62.13  ? 691  ILE A CD1 1 
ATOM   3114 N  N   . GLN A 1 429 ? 9.801   -34.101 -18.240 0.50 56.36  ? 692  GLN A N   1 
ATOM   3115 C  CA  . GLN A 1 429 ? 10.537  -32.820 -18.051 0.50 59.45  ? 692  GLN A CA  1 
ATOM   3116 C  C   . GLN A 1 429 ? 10.048  -31.802 -19.089 0.50 57.54  ? 692  GLN A C   1 
ATOM   3117 O  O   . GLN A 1 429 ? 9.972   -32.155 -20.284 0.50 52.36  ? 692  GLN A O   1 
ATOM   3118 C  CB  . GLN A 1 429 ? 12.047  -33.052 -18.162 0.50 64.92  ? 692  GLN A CB  1 
ATOM   3119 C  CG  . GLN A 1 429 ? 12.900  -31.911 -17.610 0.50 71.08  ? 692  GLN A CG  1 
ATOM   3120 C  CD  . GLN A 1 429 ? 13.419  -30.955 -18.662 0.50 75.72  ? 692  GLN A CD  1 
ATOM   3121 O  OE1 . GLN A 1 429 ? 14.015  -31.349 -19.666 0.50 80.50  ? 692  GLN A OE1 1 
ATOM   3122 N  NE2 . GLN A 1 429 ? 13.223  -29.668 -18.423 0.50 77.22  ? 692  GLN A NE2 1 
ATOM   3123 N  N   . GLN A 1 430 ? 9.762   -30.579 -18.637 0.50 58.80  ? 693  GLN A N   1 
ATOM   3124 C  CA  . GLN A 1 430 ? 9.115   -29.496 -19.428 0.50 62.68  ? 693  GLN A CA  1 
ATOM   3125 C  C   . GLN A 1 430 ? 9.675   -29.454 -20.859 0.50 59.57  ? 693  GLN A C   1 
ATOM   3126 O  O   . GLN A 1 430 ? 8.864   -29.296 -21.797 0.50 56.44  ? 693  GLN A O   1 
ATOM   3127 C  CB  . GLN A 1 430 ? 9.278   -28.149 -18.715 0.50 64.89  ? 693  GLN A CB  1 
ATOM   3128 C  CG  . GLN A 1 430 ? 8.656   -26.994 -19.484 0.50 67.97  ? 693  GLN A CG  1 
ATOM   3129 C  CD  . GLN A 1 430 ? 7.974   -25.970 -18.609 0.50 71.14  ? 693  GLN A CD  1 
ATOM   3130 O  OE1 . GLN A 1 430 ? 7.540   -26.258 -17.493 0.50 72.36  ? 693  GLN A OE1 1 
ATOM   3131 N  NE2 . GLN A 1 430 ? 7.847   -24.761 -19.134 0.50 69.23  ? 693  GLN A NE2 1 
ATOM   3132 N  N   . TRP A 1 431 ? 10.996  -29.584 -21.028 1.00 59.33  ? 694  TRP A N   1 
ATOM   3133 C  CA  . TRP A 1 431 ? 11.668  -29.434 -22.355 1.00 52.71  ? 694  TRP A CA  1 
ATOM   3134 C  C   . TRP A 1 431 ? 12.117  -30.749 -22.997 1.00 48.52  ? 694  TRP A C   1 
ATOM   3135 O  O   . TRP A 1 431 ? 12.785  -30.696 -24.035 1.00 49.69  ? 694  TRP A O   1 
ATOM   3136 C  CB  . TRP A 1 431 ? 12.785  -28.393 -22.236 1.00 60.54  ? 694  TRP A CB  1 
ATOM   3137 C  CG  . TRP A 1 431 ? 12.193  -27.084 -21.799 1.00 66.04  ? 694  TRP A CG  1 
ATOM   3138 C  CD1 . TRP A 1 431 ? 12.237  -26.548 -20.547 1.00 62.36  ? 694  TRP A CD1 1 
ATOM   3139 C  CD2 . TRP A 1 431 ? 11.335  -26.215 -22.575 1.00 69.99  ? 694  TRP A CD2 1 
ATOM   3140 N  NE1 . TRP A 1 431 ? 11.515  -25.383 -20.506 1.00 70.77  ? 694  TRP A NE1 1 
ATOM   3141 C  CE2 . TRP A 1 431 ? 10.944  -25.152 -21.728 1.00 64.87  ? 694  TRP A CE2 1 
ATOM   3142 C  CE3 . TRP A 1 431 ? 10.873  -26.216 -23.903 1.00 70.73  ? 694  TRP A CE3 1 
ATOM   3143 C  CZ2 . TRP A 1 431 ? 10.102  -24.121 -22.152 1.00 63.65  ? 694  TRP A CZ2 1 
ATOM   3144 C  CZ3 . TRP A 1 431 ? 10.056  -25.184 -24.331 1.00 68.45  ? 694  TRP A CZ3 1 
ATOM   3145 C  CH2 . TRP A 1 431 ? 9.674   -24.154 -23.464 1.00 64.67  ? 694  TRP A CH2 1 
ATOM   3146 N  N   . GLU A 1 432 ? 11.733  -31.888 -22.411 0.50 48.54  ? 695  GLU A N   1 
ATOM   3147 C  CA  . GLU A 1 432 ? 12.070  -33.252 -22.900 0.50 51.36  ? 695  GLU A CA  1 
ATOM   3148 C  C   . GLU A 1 432 ? 11.082  -33.642 -23.999 0.50 51.76  ? 695  GLU A C   1 
ATOM   3149 O  O   . GLU A 1 432 ? 9.873   -33.479 -23.844 0.50 51.01  ? 695  GLU A O   1 
ATOM   3150 C  CB  . GLU A 1 432 ? 12.058  -34.240 -21.728 0.50 55.10  ? 695  GLU A CB  1 
ATOM   3151 C  CG  . GLU A 1 432 ? 12.293  -35.691 -22.125 0.50 59.75  ? 695  GLU A CG  1 
ATOM   3152 C  CD  . GLU A 1 432 ? 13.726  -36.062 -22.486 0.50 64.71  ? 695  GLU A CD  1 
ATOM   3153 O  OE1 . GLU A 1 432 ? 13.930  -37.180 -23.019 0.50 63.47  ? 695  GLU A OE1 1 
ATOM   3154 O  OE2 . GLU A 1 432 ? 14.640  -35.237 -22.235 0.50 69.57  ? 695  GLU A OE2 1 
ATOM   3155 N  N   . PRO A 1 433 ? 11.565  -34.166 -25.147 0.50 48.43  ? 696  PRO A N   1 
ATOM   3156 C  CA  . PRO A 1 433 ? 10.691  -34.504 -26.269 0.50 46.61  ? 696  PRO A CA  1 
ATOM   3157 C  C   . PRO A 1 433 ? 9.636   -35.547 -25.879 0.50 46.35  ? 696  PRO A C   1 
ATOM   3158 O  O   . PRO A 1 433 ? 9.919   -36.375 -25.044 0.50 46.02  ? 696  PRO A O   1 
ATOM   3159 C  CB  . PRO A 1 433 ? 11.641  -35.068 -27.338 0.50 48.42  ? 696  PRO A CB  1 
ATOM   3160 C  CG  . PRO A 1 433 ? 13.020  -34.556 -26.938 0.50 48.11  ? 696  PRO A CG  1 
ATOM   3161 C  CD  . PRO A 1 433 ? 12.978  -34.461 -25.426 0.50 48.47  ? 696  PRO A CD  1 
ATOM   3162 N  N   . SER A 1 434 ? 8.438   -35.449 -26.465 1.00 47.16  ? 697  SER A N   1 
ATOM   3163 C  CA  . SER A 1 434 ? 7.334   -36.405 -26.234 1.00 40.15  ? 697  SER A CA  1 
ATOM   3164 C  C   . SER A 1 434 ? 7.757   -37.783 -26.749 1.00 40.73  ? 697  SER A C   1 
ATOM   3165 O  O   . SER A 1 434 ? 8.345   -37.871 -27.817 1.00 41.90  ? 697  SER A O   1 
ATOM   3166 C  CB  . SER A 1 434 ? 6.099   -35.932 -26.962 1.00 35.29  ? 697  SER A CB  1 
ATOM   3167 O  OG  . SER A 1 434 ? 5.468   -34.882 -26.270 1.00 35.41  ? 697  SER A OG  1 
ATOM   3168 N  N   . ARG A 1 435 ? 7.475   -38.827 -25.970 0.50 42.21  ? 698  ARG A N   1 
ATOM   3169 C  CA  . ARG A 1 435 ? 7.559   -40.246 -26.405 0.50 47.37  ? 698  ARG A CA  1 
ATOM   3170 C  C   . ARG A 1 435 ? 6.296   -40.557 -27.216 0.50 48.30  ? 698  ARG A C   1 
ATOM   3171 O  O   . ARG A 1 435 ? 5.202   -40.454 -26.641 0.50 48.61  ? 698  ARG A O   1 
ATOM   3172 C  CB  . ARG A 1 435 ? 7.669   -41.186 -25.197 0.50 48.92  ? 698  ARG A CB  1 
ATOM   3173 C  CG  . ARG A 1 435 ? 8.785   -40.837 -24.222 0.50 52.82  ? 698  ARG A CG  1 
ATOM   3174 C  CD  . ARG A 1 435 ? 8.968   -41.881 -23.127 0.50 55.92  ? 698  ARG A CD  1 
ATOM   3175 N  NE  . ARG A 1 435 ? 8.050   -41.718 -22.002 0.50 58.11  ? 698  ARG A NE  1 
ATOM   3176 C  CZ  . ARG A 1 435 ? 8.304   -40.998 -20.909 0.50 58.29  ? 698  ARG A CZ  1 
ATOM   3177 N  NH1 . ARG A 1 435 ? 9.454   -40.359 -20.779 0.50 58.30  ? 698  ARG A NH1 1 
ATOM   3178 N  NH2 . ARG A 1 435 ? 7.402   -40.910 -19.949 0.50 58.34  ? 698  ARG A NH2 1 
ATOM   3179 N  N   . GLY A 1 436 ? 6.438   -40.876 -28.505 1.00 46.83  ? 699  GLY A N   1 
ATOM   3180 C  CA  . GLY A 1 436 ? 5.300   -41.287 -29.346 1.00 51.00  ? 699  GLY A CA  1 
ATOM   3181 C  C   . GLY A 1 436 ? 5.046   -42.790 -29.269 1.00 50.25  ? 699  GLY A C   1 
ATOM   3182 O  O   . GLY A 1 436 ? 5.869   -43.482 -28.690 1.00 51.47  ? 699  GLY A O   1 
ATOM   3183 N  N   . TRP A 1 437 ? 3.976   -43.270 -29.905 1.00 42.58  ? 700  TRP A N   1 
ATOM   3184 C  CA  . TRP A 1 437 ? 3.581   -44.692 -30.016 1.00 37.76  ? 700  TRP A CA  1 
ATOM   3185 C  C   . TRP A 1 437 ? 3.626   -45.071 -31.477 1.00 37.61  ? 700  TRP A C   1 
ATOM   3186 O  O   . TRP A 1 437 ? 3.178   -44.248 -32.295 1.00 37.12  ? 700  TRP A O   1 
ATOM   3187 C  CB  . TRP A 1 437 ? 2.152   -44.875 -29.518 1.00 37.95  ? 700  TRP A CB  1 
ATOM   3188 C  CG  . TRP A 1 437 ? 1.938   -44.413 -28.125 1.00 35.00  ? 700  TRP A CG  1 
ATOM   3189 C  CD1 . TRP A 1 437 ? 1.594   -43.167 -27.712 1.00 39.89  ? 700  TRP A CD1 1 
ATOM   3190 C  CD2 . TRP A 1 437 ? 2.021   -45.230 -26.953 1.00 35.36  ? 700  TRP A CD2 1 
ATOM   3191 N  NE1 . TRP A 1 437 ? 1.487   -43.145 -26.351 1.00 38.81  ? 700  TRP A NE1 1 
ATOM   3192 C  CE2 . TRP A 1 437 ? 1.728   -44.398 -25.859 1.00 33.38  ? 700  TRP A CE2 1 
ATOM   3193 C  CE3 . TRP A 1 437 ? 2.284   -46.581 -26.739 1.00 37.65  ? 700  TRP A CE3 1 
ATOM   3194 C  CZ2 . TRP A 1 437 ? 1.712   -44.869 -24.557 1.00 33.56  ? 700  TRP A CZ2 1 
ATOM   3195 C  CZ3 . TRP A 1 437 ? 2.263   -47.050 -25.452 1.00 37.75  ? 700  TRP A CZ3 1 
ATOM   3196 C  CH2 . TRP A 1 437 ? 1.978   -46.203 -24.383 1.00 35.27  ? 700  TRP A CH2 1 
ATOM   3197 N  N   . ASN A 1 438 ? 4.046   -46.284 -31.789 1.00 38.62  ? 701  ASN A N   1 
ATOM   3198 C  CA  . ASN A 1 438 ? 4.238   -46.718 -33.203 1.00 45.65  ? 701  ASN A CA  1 
ATOM   3199 C  C   . ASN A 1 438 ? 3.100   -47.603 -33.694 1.00 44.86  ? 701  ASN A C   1 
ATOM   3200 O  O   . ASN A 1 438 ? 3.114   -47.934 -34.887 1.00 44.00  ? 701  ASN A O   1 
ATOM   3201 C  CB  . ASN A 1 438 ? 5.518   -47.545 -33.376 1.00 48.98  ? 701  ASN A CB  1 
ATOM   3202 C  CG  . ASN A 1 438 ? 6.743   -46.664 -33.338 1.00 52.88  ? 701  ASN A CG  1 
ATOM   3203 O  OD1 . ASN A 1 438 ? 7.728   -47.018 -32.684 1.00 74.38  ? 701  ASN A OD1 1 
ATOM   3204 N  ND2 . ASN A 1 438 ? 6.661   -45.516 -34.003 1.00 45.32  ? 701  ASN A ND2 1 
ATOM   3205 N  N   . ASP A 1 439 ? 2.238   -48.044 -32.788 1.00 43.55  ? 702  ASP A N   1 
ATOM   3206 C  CA  . ASP A 1 439 ? 1.140   -49.007 -33.076 1.00 48.29  ? 702  ASP A CA  1 
ATOM   3207 C  C   . ASP A 1 439 ? -0.142  -48.407 -32.489 1.00 42.36  ? 702  ASP A C   1 
ATOM   3208 O  O   . ASP A 1 439 ? -0.176  -48.132 -31.259 1.00 40.36  ? 702  ASP A O   1 
ATOM   3209 C  CB  . ASP A 1 439 ? 1.605   -50.357 -32.510 1.00 51.13  ? 702  ASP A CB  1 
ATOM   3210 C  CG  . ASP A 1 439 ? 0.588   -51.483 -32.433 1.00 62.16  ? 702  ASP A CG  1 
ATOM   3211 O  OD1 . ASP A 1 439 ? -0.483  -51.380 -33.118 1.00 56.40  ? 702  ASP A OD1 1 
ATOM   3212 O  OD2 . ASP A 1 439 ? 0.904   -52.485 -31.701 1.00 57.93  ? 702  ASP A OD2 1 
ATOM   3213 N  N   . TRP A 1 440 ? -1.171  -48.190 -33.297 1.00 41.54  ? 703  TRP A N   1 
ATOM   3214 C  CA  . TRP A 1 440 ? -2.439  -47.606 -32.785 1.00 37.28  ? 703  TRP A CA  1 
ATOM   3215 C  C   . TRP A 1 440 ? -3.070  -48.480 -31.679 1.00 35.08  ? 703  TRP A C   1 
ATOM   3216 O  O   . TRP A 1 440 ? -3.852  -47.946 -30.846 1.00 32.75  ? 703  TRP A O   1 
ATOM   3217 C  CB  . TRP A 1 440 ? -3.407  -47.326 -33.929 1.00 39.90  ? 703  TRP A CB  1 
ATOM   3218 C  CG  . TRP A 1 440 ? -3.866  -48.568 -34.633 1.00 43.22  ? 703  TRP A CG  1 
ATOM   3219 C  CD1 . TRP A 1 440 ? -3.283  -49.181 -35.706 1.00 42.22  ? 703  TRP A CD1 1 
ATOM   3220 C  CD2 . TRP A 1 440 ? -5.008  -49.361 -34.293 1.00 39.13  ? 703  TRP A CD2 1 
ATOM   3221 N  NE1 . TRP A 1 440 ? -4.000  -50.290 -36.063 1.00 41.88  ? 703  TRP A NE1 1 
ATOM   3222 C  CE2 . TRP A 1 440 ? -5.052  -50.440 -35.205 1.00 39.91  ? 703  TRP A CE2 1 
ATOM   3223 C  CE3 . TRP A 1 440 ? -6.018  -49.241 -33.342 1.00 40.74  ? 703  TRP A CE3 1 
ATOM   3224 C  CZ2 . TRP A 1 440 ? -6.046  -51.417 -35.166 1.00 39.98  ? 703  TRP A CZ2 1 
ATOM   3225 C  CZ3 . TRP A 1 440 ? -7.012  -50.199 -33.313 1.00 40.03  ? 703  TRP A CZ3 1 
ATOM   3226 C  CH2 . TRP A 1 440 ? -7.013  -51.276 -34.201 1.00 41.82  ? 703  TRP A CH2 1 
ATOM   3227 N  N   . THR A 1 441 ? -2.719  -49.757 -31.588 1.00 32.88  ? 704  THR A N   1 
ATOM   3228 C  CA  . THR A 1 441 ? -3.304  -50.688 -30.580 1.00 36.44  ? 704  THR A CA  1 
ATOM   3229 C  C   . THR A 1 441 ? -2.640  -50.565 -29.193 1.00 38.30  ? 704  THR A C   1 
ATOM   3230 O  O   . THR A 1 441 ? -3.055  -51.302 -28.237 1.00 39.35  ? 704  THR A O   1 
ATOM   3231 C  CB  . THR A 1 441 ? -3.293  -52.135 -31.096 1.00 35.02  ? 704  THR A CB  1 
ATOM   3232 O  OG1 . THR A 1 441 ? -1.963  -52.602 -31.158 1.00 39.05  ? 704  THR A OG1 1 
ATOM   3233 C  CG2 . THR A 1 441 ? -3.874  -52.322 -32.480 1.00 35.60  ? 704  THR A CG2 1 
ATOM   3234 N  N   . GLN A 1 442 ? -1.655  -49.669 -29.059 0.50 38.29  ? 705  GLN A N   1 
ATOM   3235 C  CA  . GLN A 1 442 ? -0.960  -49.374 -27.776 0.50 39.36  ? 705  GLN A CA  1 
ATOM   3236 C  C   . GLN A 1 442 ? -1.299  -47.961 -27.272 0.50 35.27  ? 705  GLN A C   1 
ATOM   3237 O  O   . GLN A 1 442 ? -1.017  -47.685 -26.084 0.50 35.25  ? 705  GLN A O   1 
ATOM   3238 C  CB  . GLN A 1 442 ? 0.549   -49.523 -27.973 0.50 41.71  ? 705  GLN A CB  1 
ATOM   3239 C  CG  . GLN A 1 442 ? 0.922   -50.769 -28.754 0.50 42.83  ? 705  GLN A CG  1 
ATOM   3240 C  CD  . GLN A 1 442 ? 0.575   -52.018 -27.988 0.50 45.71  ? 705  GLN A CD  1 
ATOM   3241 O  OE1 . GLN A 1 442 ? 1.019   -52.200 -26.855 0.50 43.02  ? 705  GLN A OE1 1 
ATOM   3242 N  NE2 . GLN A 1 442 ? -0.216  -52.892 -28.608 0.50 46.36  ? 705  GLN A NE2 1 
ATOM   3243 N  N   . VAL A 1 443 ? -1.845  -47.095 -28.132 1.00 33.24  ? 706  VAL A N   1 
ATOM   3244 C  CA  . VAL A 1 443 ? -2.164  -45.675 -27.779 1.00 36.75  ? 706  VAL A CA  1 
ATOM   3245 C  C   . VAL A 1 443 ? -3.255  -45.657 -26.719 1.00 30.20  ? 706  VAL A C   1 
ATOM   3246 O  O   . VAL A 1 443 ? -4.290  -46.271 -26.905 1.00 31.85  ? 706  VAL A O   1 
ATOM   3247 C  CB  . VAL A 1 443 ? -2.631  -44.882 -29.017 1.00 40.39  ? 706  VAL A CB  1 
ATOM   3248 C  CG1 . VAL A 1 443 ? -3.065  -43.472 -28.664 1.00 45.15  ? 706  VAL A CG1 1 
ATOM   3249 C  CG2 . VAL A 1 443 ? -1.557  -44.836 -30.075 1.00 44.79  ? 706  VAL A CG2 1 
ATOM   3250 N  N   . PRO A 1 444 ? -3.080  -44.940 -25.602 1.00 29.44  ? 707  PRO A N   1 
ATOM   3251 C  CA  . PRO A 1 444 ? -4.170  -44.740 -24.649 1.00 31.82  ? 707  PRO A CA  1 
ATOM   3252 C  C   . PRO A 1 444 ? -5.087  -43.604 -25.124 1.00 29.96  ? 707  PRO A C   1 
ATOM   3253 O  O   . PRO A 1 444 ? -4.588  -42.619 -25.583 1.00 31.75  ? 707  PRO A O   1 
ATOM   3254 C  CB  . PRO A 1 444 ? -3.442  -44.359 -23.351 1.00 31.21  ? 707  PRO A CB  1 
ATOM   3255 C  CG  . PRO A 1 444 ? -2.182  -43.639 -23.854 1.00 33.22  ? 707  PRO A CG  1 
ATOM   3256 C  CD  . PRO A 1 444 ? -1.852  -44.231 -25.216 1.00 30.60  ? 707  PRO A CD  1 
ATOM   3257 N  N   . PHE A 1 445 ? -6.399  -43.751 -24.939 1.00 29.43  ? 708  PHE A N   1 
ATOM   3258 C  CA  . PHE A 1 445 ? -7.434  -42.732 -25.241 1.00 27.80  ? 708  PHE A CA  1 
ATOM   3259 C  C   . PHE A 1 445 ? -8.677  -43.067 -24.420 1.00 29.19  ? 708  PHE A C   1 
ATOM   3260 O  O   . PHE A 1 445 ? -9.105  -44.237 -24.494 1.00 27.37  ? 708  PHE A O   1 
ATOM   3261 C  CB  . PHE A 1 445 ? -7.756  -42.715 -26.742 1.00 30.88  ? 708  PHE A CB  1 
ATOM   3262 C  CG  . PHE A 1 445 ? -8.592  -41.547 -27.223 1.00 32.13  ? 708  PHE A CG  1 
ATOM   3263 C  CD1 . PHE A 1 445 ? -8.310  -40.248 -26.833 1.00 35.77  ? 708  PHE A CD1 1 
ATOM   3264 C  CD2 . PHE A 1 445 ? -9.668  -41.744 -28.077 1.00 36.87  ? 708  PHE A CD2 1 
ATOM   3265 C  CE1 . PHE A 1 445 ? -9.083  -39.175 -27.272 1.00 39.24  ? 708  PHE A CE1 1 
ATOM   3266 C  CE2 . PHE A 1 445 ? -10.437 -40.673 -28.533 1.00 39.50  ? 708  PHE A CE2 1 
ATOM   3267 C  CZ  . PHE A 1 445 ? -10.148 -39.386 -28.122 1.00 39.00  ? 708  PHE A CZ  1 
ATOM   3268 N  N   . CYS A 1 446 ? -9.238  -42.064 -23.735 1.00 29.90  ? 709  CYS A N   1 
ATOM   3269 C  CA  . CYS A 1 446 ? -10.445 -42.105 -22.847 1.00 30.39  ? 709  CYS A CA  1 
ATOM   3270 C  C   . CYS A 1 446 ? -10.378 -43.301 -21.894 1.00 29.60  ? 709  CYS A C   1 
ATOM   3271 O  O   . CYS A 1 446 ? -11.355 -44.042 -21.831 1.00 30.99  ? 709  CYS A O   1 
ATOM   3272 C  CB  . CYS A 1 446 ? -11.724 -42.108 -23.661 1.00 33.39  ? 709  CYS A CB  1 
ATOM   3273 S  SG  . CYS A 1 446 ? -11.843 -40.721 -24.824 1.00 36.39  ? 709  CYS A SG  1 
ATOM   3274 N  N   . SER A 1 447 ? -9.199  -43.557 -21.323 1.00 29.74  ? 710  SER A N   1 
ATOM   3275 C  CA  . SER A 1 447 ? -8.955  -44.604 -20.309 1.00 33.96  ? 710  SER A CA  1 
ATOM   3276 C  C   . SER A 1 447 ? -8.953  -45.997 -20.950 1.00 35.27  ? 710  SER A C   1 
ATOM   3277 O  O   . SER A 1 447 ? -8.981  -46.975 -20.201 1.00 34.61  ? 710  SER A O   1 
ATOM   3278 C  CB  . SER A 1 447 ? -10.003 -44.528 -19.218 1.00 39.72  ? 710  SER A CB  1 
ATOM   3279 O  OG  . SER A 1 447 ? -10.051 -43.237 -18.637 1.00 43.22  ? 710  SER A OG  1 
ATOM   3280 N  N   . HIS A 1 448 ? -8.950  -46.098 -22.274 1.00 33.58  ? 711  HIS A N   1 
ATOM   3281 C  CA  . HIS A 1 448 ? -8.938  -47.399 -22.984 1.00 29.79  ? 711  HIS A CA  1 
ATOM   3282 C  C   . HIS A 1 448 ? -7.711  -47.565 -23.878 1.00 31.03  ? 711  HIS A C   1 
ATOM   3283 O  O   . HIS A 1 448 ? -7.022  -46.559 -24.184 1.00 25.67  ? 711  HIS A O   1 
ATOM   3284 C  CB  . HIS A 1 448 ? -10.201 -47.558 -23.824 1.00 29.58  ? 711  HIS A CB  1 
ATOM   3285 C  CG  . HIS A 1 448 ? -11.410 -47.763 -22.970 1.00 30.52  ? 711  HIS A CG  1 
ATOM   3286 N  ND1 . HIS A 1 448 ? -11.962 -46.734 -22.228 1.00 31.55  ? 711  HIS A ND1 1 
ATOM   3287 C  CD2 . HIS A 1 448 ? -12.130 -48.867 -22.692 1.00 32.12  ? 711  HIS A CD2 1 
ATOM   3288 C  CE1 . HIS A 1 448 ? -12.952 -47.207 -21.503 1.00 31.50  ? 711  HIS A CE1 1 
ATOM   3289 N  NE2 . HIS A 1 448 ? -13.110 -48.515 -21.782 1.00 31.16  ? 711  HIS A NE2 1 
ATOM   3290 N  N   . HIS A 1 449 ? -7.449  -48.826 -24.263 1.00 29.82  ? 712  HIS A N   1 
ATOM   3291 C  CA  . HIS A 1 449 ? -6.705  -49.178 -25.494 1.00 28.08  ? 712  HIS A CA  1 
ATOM   3292 C  C   . HIS A 1 449 ? -7.642  -50.039 -26.335 1.00 27.69  ? 712  HIS A C   1 
ATOM   3293 O  O   . HIS A 1 449 ? -8.703  -50.448 -25.844 1.00 27.02  ? 712  HIS A O   1 
ATOM   3294 C  CB  . HIS A 1 449 ? -5.363  -49.833 -25.157 1.00 26.47  ? 712  HIS A CB  1 
ATOM   3295 C  CG  . HIS A 1 449 ? -5.517  -51.060 -24.353 1.00 25.37  ? 712  HIS A CG  1 
ATOM   3296 N  ND1 . HIS A 1 449 ? -5.750  -50.998 -22.994 1.00 27.68  ? 712  HIS A ND1 1 
ATOM   3297 C  CD2 . HIS A 1 449 ? -5.563  -52.359 -24.715 1.00 26.40  ? 712  HIS A CD2 1 
ATOM   3298 C  CE1 . HIS A 1 449 ? -5.894  -52.237 -22.532 1.00 26.96  ? 712  HIS A CE1 1 
ATOM   3299 N  NE2 . HIS A 1 449 ? -5.815  -53.095 -23.589 1.00 26.31  ? 712  HIS A NE2 1 
ATOM   3300 N  N   . PHE A 1 450 ? -7.255  -50.305 -27.582 0.40 28.38  ? 713  PHE A N   1 
ATOM   3301 C  CA  . PHE A 1 450 ? -8.100  -50.997 -28.585 0.40 29.96  ? 713  PHE A CA  1 
ATOM   3302 C  C   . PHE A 1 450 ? -7.331  -52.166 -29.207 0.40 30.53  ? 713  PHE A C   1 
ATOM   3303 O  O   . PHE A 1 450 ? -6.128  -52.011 -29.529 0.40 29.94  ? 713  PHE A O   1 
ATOM   3304 C  CB  . PHE A 1 450 ? -8.619  -49.965 -29.586 0.40 31.30  ? 713  PHE A CB  1 
ATOM   3305 C  CG  . PHE A 1 450 ? -9.388  -48.870 -28.893 0.40 32.36  ? 713  PHE A CG  1 
ATOM   3306 C  CD1 . PHE A 1 450 ? -8.722  -47.844 -28.244 0.40 32.50  ? 713  PHE A CD1 1 
ATOM   3307 C  CD2 . PHE A 1 450 ? -10.767 -48.916 -28.806 0.40 32.53  ? 713  PHE A CD2 1 
ATOM   3308 C  CE1 . PHE A 1 450 ? -9.422  -46.864 -27.563 0.40 32.29  ? 713  PHE A CE1 1 
ATOM   3309 C  CE2 . PHE A 1 450 ? -11.465 -47.923 -28.139 0.40 33.42  ? 713  PHE A CE2 1 
ATOM   3310 C  CZ  . PHE A 1 450 ? -10.790 -46.908 -27.510 0.40 32.69  ? 713  PHE A CZ  1 
ATOM   3311 N  N   . HIS A 1 451 ? -8.011  -53.315 -29.332 1.00 30.11  ? 714  HIS A N   1 
ATOM   3312 C  CA  . HIS A 1 451 ? -7.457  -54.534 -29.955 1.00 33.07  ? 714  HIS A CA  1 
ATOM   3313 C  C   . HIS A 1 451 ? -8.144  -54.748 -31.290 1.00 33.73  ? 714  HIS A C   1 
ATOM   3314 O  O   . HIS A 1 451 ? -9.365  -54.495 -31.376 1.00 38.71  ? 714  HIS A O   1 
ATOM   3315 C  CB  . HIS A 1 451 ? -7.635  -55.750 -29.073 1.00 32.59  ? 714  HIS A CB  1 
ATOM   3316 C  CG  . HIS A 1 451 ? -7.013  -55.689 -27.719 1.00 31.03  ? 714  HIS A CG  1 
ATOM   3317 N  ND1 . HIS A 1 451 ? -5.931  -56.427 -27.415 1.00 32.03  ? 714  HIS A ND1 1 
ATOM   3318 C  CD2 . HIS A 1 451 ? -7.442  -55.161 -26.542 1.00 35.40  ? 714  HIS A CD2 1 
ATOM   3319 C  CE1 . HIS A 1 451 ? -5.658  -56.300 -26.117 1.00 34.42  ? 714  HIS A CE1 1 
ATOM   3320 N  NE2 . HIS A 1 451 ? -6.569  -55.503 -25.552 1.00 26.52  ? 714  HIS A NE2 1 
ATOM   3321 N  N   . GLU A 1 452 ? -7.388  -55.230 -32.269 1.00 36.47  ? 715  GLU A N   1 
ATOM   3322 C  CA  . GLU A 1 452 ? -7.948  -55.818 -33.511 1.00 40.35  ? 715  GLU A CA  1 
ATOM   3323 C  C   . GLU A 1 452 ? -8.271  -57.280 -33.205 1.00 42.45  ? 715  GLU A C   1 
ATOM   3324 O  O   . GLU A 1 452 ? -7.406  -58.016 -32.736 1.00 47.48  ? 715  GLU A O   1 
ATOM   3325 C  CB  . GLU A 1 452 ? -6.984  -55.652 -34.668 1.00 45.40  ? 715  GLU A CB  1 
ATOM   3326 C  CG  . GLU A 1 452 ? -7.691  -55.160 -35.913 1.00 54.98  ? 715  GLU A CG  1 
ATOM   3327 C  CD  . GLU A 1 452 ? -6.801  -55.002 -37.129 1.00 58.96  ? 715  GLU A CD  1 
ATOM   3328 O  OE1 . GLU A 1 452 ? -7.112  -54.100 -37.968 1.00 56.19  ? 715  GLU A OE1 1 
ATOM   3329 O  OE2 . GLU A 1 452 ? -5.804  -55.786 -37.235 1.00 68.16  ? 715  GLU A OE2 1 
ATOM   3330 N  N   . LEU A 1 453 ? -9.526  -57.665 -33.422 0.48 41.67  ? 716  LEU A N   1 
ATOM   3331 C  CA  . LEU A 1 453 ? -10.050 -59.015 -33.104 0.48 43.72  ? 716  LEU A CA  1 
ATOM   3332 C  C   . LEU A 1 453 ? -10.714 -59.582 -34.359 0.48 43.63  ? 716  LEU A C   1 
ATOM   3333 O  O   . LEU A 1 453 ? -11.655 -58.946 -34.868 0.48 43.16  ? 716  LEU A O   1 
ATOM   3334 C  CB  . LEU A 1 453 ? -11.032 -58.877 -31.940 0.48 45.34  ? 716  LEU A CB  1 
ATOM   3335 C  CG  . LEU A 1 453 ? -11.759 -60.144 -31.510 0.48 47.10  ? 716  LEU A CG  1 
ATOM   3336 C  CD1 . LEU A 1 453 ? -10.796 -61.311 -31.374 0.48 49.67  ? 716  LEU A CD1 1 
ATOM   3337 C  CD2 . LEU A 1 453 ? -12.497 -59.899 -30.202 0.48 49.99  ? 716  LEU A CD2 1 
ATOM   3338 N  N   . ILE A 1 454 ? -10.213 -60.715 -34.850 0.48 44.59  ? 717  ILE A N   1 
ATOM   3339 C  CA  . ILE A 1 454 ? -10.693 -61.361 -36.106 0.48 46.62  ? 717  ILE A CA  1 
ATOM   3340 C  C   . ILE A 1 454 ? -11.741 -62.420 -35.747 0.48 45.69  ? 717  ILE A C   1 
ATOM   3341 O  O   . ILE A 1 454 ? -11.409 -63.361 -34.996 0.48 45.40  ? 717  ILE A O   1 
ATOM   3342 C  CB  . ILE A 1 454 ? -9.504  -61.939 -36.898 0.48 51.86  ? 717  ILE A CB  1 
ATOM   3343 C  CG1 . ILE A 1 454 ? -8.517  -60.840 -37.303 0.48 53.53  ? 717  ILE A CG1 1 
ATOM   3344 C  CG2 . ILE A 1 454 ? -9.987  -62.726 -38.107 0.48 53.47  ? 717  ILE A CG2 1 
ATOM   3345 C  CD1 . ILE A 1 454 ? -7.124  -61.345 -37.599 0.48 55.74  ? 717  ILE A CD1 1 
ATOM   3346 N  N   . MET A 1 455 ? -12.964 -62.263 -36.263 1.00 44.41  ? 718  MET A N   1 
ATOM   3347 C  CA  . MET A 1 455 ? -14.065 -63.255 -36.055 1.00 49.05  ? 718  MET A CA  1 
ATOM   3348 C  C   . MET A 1 455 ? -13.766 -64.537 -36.844 1.00 46.71  ? 718  MET A C   1 
ATOM   3349 O  O   . MET A 1 455 ? -13.067 -64.475 -37.852 1.00 44.99  ? 718  MET A O   1 
ATOM   3350 C  CB  . MET A 1 455 ? -15.408 -62.689 -36.524 1.00 46.55  ? 718  MET A CB  1 
ATOM   3351 C  CG  . MET A 1 455 ? -15.776 -61.406 -35.830 1.00 50.42  ? 718  MET A CG  1 
ATOM   3352 S  SD  . MET A 1 455 ? -17.354 -60.746 -36.359 1.00 54.25  ? 718  MET A SD  1 
ATOM   3353 C  CE  . MET A 1 455 ? -18.374 -62.013 -35.612 1.00 47.21  ? 718  MET A CE  1 
ATOM   3354 N  N   A LYS A 1 456 ? -14.294 -65.671 -36.377 0.24 48.63  ? 719  LYS A N   1 
ATOM   3355 N  N   B LYS A 1 456 ? -14.319 -65.664 -36.396 0.24 48.33  ? 719  LYS A N   1 
ATOM   3356 C  CA  A LYS A 1 456 ? -14.133 -67.002 -37.029 0.24 51.45  ? 719  LYS A CA  1 
ATOM   3357 C  CA  B LYS A 1 456 ? -14.112 -66.995 -37.027 0.24 50.96  ? 719  LYS A CA  1 
ATOM   3358 C  C   A LYS A 1 456 ? -14.431 -66.885 -38.533 0.24 51.62  ? 719  LYS A C   1 
ATOM   3359 C  C   B LYS A 1 456 ? -14.494 -66.934 -38.518 0.24 51.56  ? 719  LYS A C   1 
ATOM   3360 O  O   A LYS A 1 456 ? -13.831 -67.657 -39.303 0.24 53.91  ? 719  LYS A O   1 
ATOM   3361 O  O   B LYS A 1 456 ? -14.034 -67.815 -39.263 0.24 55.26  ? 719  LYS A O   1 
ATOM   3362 C  CB  A LYS A 1 456 ? -15.019 -68.048 -36.343 0.24 53.06  ? 719  LYS A CB  1 
ATOM   3363 C  CB  B LYS A 1 456 ? -14.887 -68.072 -36.262 0.24 51.74  ? 719  LYS A CB  1 
ATOM   3364 C  CG  A LYS A 1 456 ? -14.445 -68.626 -35.056 0.24 57.14  ? 719  LYS A CG  1 
ATOM   3365 C  CG  B LYS A 1 456 ? -14.487 -69.502 -36.598 0.24 55.23  ? 719  LYS A CG  1 
ATOM   3366 C  CD  A LYS A 1 456 ? -15.329 -69.666 -34.384 0.24 59.91  ? 719  LYS A CD  1 
ATOM   3367 C  CD  B LYS A 1 456 ? -14.973 -70.547 -35.609 0.24 57.77  ? 719  LYS A CD  1 
ATOM   3368 C  CE  A LYS A 1 456 ? -16.460 -69.064 -33.573 0.24 59.96  ? 719  LYS A CE  1 
ATOM   3369 C  CE  B LYS A 1 456 ? -15.059 -71.931 -36.221 0.24 59.82  ? 719  LYS A CE  1 
ATOM   3370 N  NZ  A LYS A 1 456 ? -17.398 -70.103 -33.084 0.24 58.86  ? 719  LYS A NZ  1 
ATOM   3371 N  NZ  B LYS A 1 456 ? -15.369 -72.967 -35.208 0.24 62.32  ? 719  LYS A NZ  1 
ATOM   3372 N  N   . ASP A 1 457 ? -15.275 -65.928 -38.939 1.00 49.32  ? 720  ASP A N   1 
ATOM   3373 C  CA  . ASP A 1 457 ? -15.645 -65.700 -40.375 1.00 48.77  ? 720  ASP A CA  1 
ATOM   3374 C  C   . ASP A 1 457 ? -14.823 -64.591 -41.064 1.00 51.22  ? 720  ASP A C   1 
ATOM   3375 O  O   . ASP A 1 457 ? -15.328 -64.056 -42.069 1.00 53.50  ? 720  ASP A O   1 
ATOM   3376 C  CB  . ASP A 1 457 ? -17.129 -65.309 -40.492 1.00 56.76  ? 720  ASP A CB  1 
ATOM   3377 C  CG  . ASP A 1 457 ? -17.498 -64.037 -39.743 1.00 62.78  ? 720  ASP A CG  1 
ATOM   3378 O  OD1 . ASP A 1 457 ? -16.814 -63.006 -39.976 1.00 56.39  ? 720  ASP A OD1 1 
ATOM   3379 O  OD2 . ASP A 1 457 ? -18.433 -64.097 -38.899 1.00 65.07  ? 720  ASP A OD2 1 
ATOM   3380 N  N   . GLY A 1 458 ? -13.667 -64.178 -40.521 1.00 54.87  ? 721  GLY A N   1 
ATOM   3381 C  CA  . GLY A 1 458 ? -12.690 -63.275 -41.175 1.00 50.40  ? 721  GLY A CA  1 
ATOM   3382 C  C   . GLY A 1 458 ? -13.003 -61.785 -41.035 1.00 51.83  ? 721  GLY A C   1 
ATOM   3383 O  O   . GLY A 1 458 ? -12.090 -60.971 -41.273 1.00 62.93  ? 721  GLY A O   1 
ATOM   3384 N  N   . ARG A 1 459 ? -14.220 -61.415 -40.627 1.00 50.30  ? 722  ARG A N   1 
ATOM   3385 C  CA  . ARG A 1 459 ? -14.592 -60.003 -40.363 1.00 46.96  ? 722  ARG A CA  1 
ATOM   3386 C  C   . ARG A 1 459 ? -13.847 -59.494 -39.125 1.00 51.15  ? 722  ARG A C   1 
ATOM   3387 O  O   . ARG A 1 459 ? -13.622 -60.277 -38.161 1.00 50.51  ? 722  ARG A O   1 
ATOM   3388 C  CB  . ARG A 1 459 ? -16.101 -59.889 -40.169 1.00 49.77  ? 722  ARG A CB  1 
ATOM   3389 C  CG  . ARG A 1 459 ? -16.883 -60.266 -41.416 1.00 50.22  ? 722  ARG A CG  1 
ATOM   3390 C  CD  . ARG A 1 459 ? -18.350 -59.977 -41.280 1.00 50.73  ? 722  ARG A CD  1 
ATOM   3391 N  NE  . ARG A 1 459 ? -19.009 -60.805 -40.302 1.00 47.55  ? 722  ARG A NE  1 
ATOM   3392 C  CZ  . ARG A 1 459 ? -20.305 -60.743 -40.055 1.00 50.20  ? 722  ARG A CZ  1 
ATOM   3393 N  NH1 . ARG A 1 459 ? -21.055 -59.878 -40.720 1.00 55.03  ? 722  ARG A NH1 1 
ATOM   3394 N  NH2 . ARG A 1 459 ? -20.850 -61.554 -39.163 1.00 50.61  ? 722  ARG A NH2 1 
ATOM   3395 N  N   . VAL A 1 460 ? -13.541 -58.201 -39.131 1.00 49.19  ? 723  VAL A N   1 
ATOM   3396 C  CA  . VAL A 1 460 ? -12.612 -57.565 -38.166 1.00 46.45  ? 723  VAL A CA  1 
ATOM   3397 C  C   . VAL A 1 460 ? -13.376 -56.590 -37.272 1.00 42.83  ? 723  VAL A C   1 
ATOM   3398 O  O   . VAL A 1 460 ? -13.951 -55.605 -37.772 1.00 52.27  ? 723  VAL A O   1 
ATOM   3399 C  CB  . VAL A 1 460 ? -11.428 -56.927 -38.905 1.00 55.04  ? 723  VAL A CB  1 
ATOM   3400 C  CG1 . VAL A 1 460 ? -10.233 -56.749 -37.975 1.00 59.44  ? 723  VAL A CG1 1 
ATOM   3401 C  CG2 . VAL A 1 460 ? -11.014 -57.776 -40.097 1.00 57.03  ? 723  VAL A CG2 1 
ATOM   3402 N  N   . LEU A 1 461 ? -13.392 -56.902 -35.977 1.00 36.62  ? 724  LEU A N   1 
ATOM   3403 C  CA  . LEU A 1 461 ? -13.891 -56.038 -34.892 1.00 32.59  ? 724  LEU A CA  1 
ATOM   3404 C  C   . LEU A 1 461 ? -12.706 -55.255 -34.328 1.00 36.70  ? 724  LEU A C   1 
ATOM   3405 O  O   . LEU A 1 461 ? -11.617 -55.834 -34.160 1.00 37.99  ? 724  LEU A O   1 
ATOM   3406 C  CB  . LEU A 1 461 ? -14.476 -56.918 -33.797 1.00 36.25  ? 724  LEU A CB  1 
ATOM   3407 C  CG  . LEU A 1 461 ? -15.657 -57.797 -34.211 1.00 34.84  ? 724  LEU A CG  1 
ATOM   3408 C  CD1 . LEU A 1 461 ? -15.959 -58.748 -33.085 1.00 36.68  ? 724  LEU A CD1 1 
ATOM   3409 C  CD2 . LEU A 1 461 ? -16.881 -56.976 -34.557 1.00 33.82  ? 724  LEU A CD2 1 
ATOM   3410 N  N   . VAL A 1 462 ? -12.899 -53.979 -34.052 1.00 33.07  ? 725  VAL A N   1 
ATOM   3411 C  CA  . VAL A 1 462 ? -11.960 -53.190 -33.226 1.00 32.76  ? 725  VAL A CA  1 
ATOM   3412 C  C   . VAL A 1 462 ? -12.664 -52.900 -31.901 1.00 32.23  ? 725  VAL A C   1 
ATOM   3413 O  O   . VAL A 1 462 ? -13.673 -52.197 -31.906 1.00 34.56  ? 725  VAL A O   1 
ATOM   3414 C  CB  . VAL A 1 462 ? -11.499 -51.927 -33.952 1.00 32.17  ? 725  VAL A CB  1 
ATOM   3415 C  CG1 . VAL A 1 462 ? -10.599 -51.107 -33.029 1.00 36.67  ? 725  VAL A CG1 1 
ATOM   3416 C  CG2 . VAL A 1 462 ? -10.771 -52.299 -35.222 1.00 33.52  ? 725  VAL A CG2 1 
ATOM   3417 N  N   . VAL A 1 463 ? -12.136 -53.435 -30.814 1.00 30.95  ? 726  VAL A N   1 
ATOM   3418 C  CA  . VAL A 1 463 ? -12.863 -53.519 -29.522 1.00 32.22  ? 726  VAL A CA  1 
ATOM   3419 C  C   . VAL A 1 463 ? -12.130 -52.694 -28.470 1.00 31.62  ? 726  VAL A C   1 
ATOM   3420 O  O   . VAL A 1 463 ? -10.904 -52.599 -28.469 1.00 32.15  ? 726  VAL A O   1 
ATOM   3421 C  CB  . VAL A 1 463 ? -13.000 -54.982 -29.090 1.00 32.53  ? 726  VAL A CB  1 
ATOM   3422 C  CG1 . VAL A 1 463 ? -13.855 -55.733 -30.074 1.00 33.69  ? 726  VAL A CG1 1 
ATOM   3423 C  CG2 . VAL A 1 463 ? -11.647 -55.675 -28.917 1.00 31.55  ? 726  VAL A CG2 1 
ATOM   3424 N  N   . PRO A 1 464 ? -12.857 -52.053 -27.551 1.00 29.49  ? 727  PRO A N   1 
ATOM   3425 C  CA  . PRO A 1 464 ? -12.219 -51.314 -26.476 1.00 27.63  ? 727  PRO A CA  1 
ATOM   3426 C  C   . PRO A 1 464 ? -11.858 -52.265 -25.338 1.00 29.55  ? 727  PRO A C   1 
ATOM   3427 O  O   . PRO A 1 464 ? -12.516 -53.306 -25.166 1.00 25.90  ? 727  PRO A O   1 
ATOM   3428 C  CB  . PRO A 1 464 ? -13.365 -50.372 -26.062 1.00 27.90  ? 727  PRO A CB  1 
ATOM   3429 C  CG  . PRO A 1 464 ? -14.585 -51.282 -26.145 1.00 26.19  ? 727  PRO A CG  1 
ATOM   3430 C  CD  . PRO A 1 464 ? -14.335 -52.066 -27.422 1.00 29.96  ? 727  PRO A CD  1 
ATOM   3431 N  N   . CYS A 1 465 ? -10.882 -51.845 -24.521 1.00 30.70  ? 728  CYS A N   1 
ATOM   3432 C  CA  . CYS A 1 465 ? -10.316 -52.693 -23.451 1.00 27.32  ? 728  CYS A CA  1 
ATOM   3433 C  C   . CYS A 1 465 ? -9.641  -51.805 -22.420 1.00 29.28  ? 728  CYS A C   1 
ATOM   3434 O  O   . CYS A 1 465 ? -9.166  -50.741 -22.783 1.00 26.66  ? 728  CYS A O   1 
ATOM   3435 C  CB  . CYS A 1 465 ? -9.316  -53.666 -24.074 1.00 30.80  ? 728  CYS A CB  1 
ATOM   3436 S  SG  . CYS A 1 465 ? -8.753  -54.977 -22.955 1.00 29.75  ? 728  CYS A SG  1 
ATOM   3437 N  N   . ARG A 1 466 ? -9.619  -52.243 -21.175 1.00 31.84  ? 729  ARG A N   1 
ATOM   3438 C  CA  . ARG A 1 466 ? -8.759  -51.668 -20.133 1.00 27.91  ? 729  ARG A CA  1 
ATOM   3439 C  C   . ARG A 1 466 ? -8.499  -52.723 -19.066 1.00 27.26  ? 729  ARG A C   1 
ATOM   3440 O  O   . ARG A 1 466 ? -9.093  -53.817 -19.107 1.00 28.69  ? 729  ARG A O   1 
ATOM   3441 C  CB  . ARG A 1 466 ? -9.358  -50.402 -19.559 1.00 32.40  ? 729  ARG A CB  1 
ATOM   3442 C  CG  . ARG A 1 466 ? -10.712 -50.591 -18.915 1.00 38.84  ? 729  ARG A CG  1 
ATOM   3443 C  CD  . ARG A 1 466 ? -11.404 -49.244 -18.668 1.00 36.85  ? 729  ARG A CD  1 
ATOM   3444 N  NE  . ARG A 1 466 ? -10.804 -48.493 -17.595 1.00 36.55  ? 729  ARG A NE  1 
ATOM   3445 C  CZ  . ARG A 1 466 ? -11.323 -47.403 -17.058 1.00 39.54  ? 729  ARG A CZ  1 
ATOM   3446 N  NH1 . ARG A 1 466 ? -12.488 -46.906 -17.464 1.00 39.05  ? 729  ARG A NH1 1 
ATOM   3447 N  NH2 . ARG A 1 466 ? -10.641 -46.790 -16.125 1.00 38.86  ? 729  ARG A NH2 1 
ATOM   3448 N  N   . ASN A 1 467 ? -7.557  -52.447 -18.181 1.00 30.25  ? 730  ASN A N   1 
ATOM   3449 C  CA  . ASN A 1 467 ? -7.177  -53.448 -17.154 1.00 31.68  ? 730  ASN A CA  1 
ATOM   3450 C  C   . ASN A 1 467 ? -8.467  -53.925 -16.481 1.00 27.85  ? 730  ASN A C   1 
ATOM   3451 O  O   . ASN A 1 467 ? -9.230  -53.110 -16.010 1.00 28.15  ? 730  ASN A O   1 
ATOM   3452 C  CB  . ASN A 1 467 ? -6.164  -52.916 -16.137 1.00 32.03  ? 730  ASN A CB  1 
ATOM   3453 C  CG  . ASN A 1 467 ? -5.897  -53.943 -15.063 1.00 35.84  ? 730  ASN A CG  1 
ATOM   3454 O  OD1 . ASN A 1 467 ? -6.632  -54.019 -14.097 1.00 34.47  ? 730  ASN A OD1 1 
ATOM   3455 N  ND2 . ASN A 1 467 ? -4.924  -54.815 -15.283 1.00 47.24  ? 730  ASN A ND2 1 
ATOM   3456 N  N   . GLN A 1 468 ? -8.639  -55.226 -16.366 1.00 28.60  ? 731  GLN A N   1 
ATOM   3457 C  CA  . GLN A 1 468 ? -9.944  -55.788 -15.953 1.00 27.70  ? 731  GLN A CA  1 
ATOM   3458 C  C   . GLN A 1 468 ? -10.167 -55.463 -14.481 1.00 30.25  ? 731  GLN A C   1 
ATOM   3459 O  O   . GLN A 1 468 ? -11.329 -55.380 -14.099 1.00 29.56  ? 731  GLN A O   1 
ATOM   3460 C  CB  . GLN A 1 468 ? -9.995  -57.273 -16.292 1.00 29.60  ? 731  GLN A CB  1 
ATOM   3461 C  CG  . GLN A 1 468 ? -11.364 -57.892 -16.097 1.00 29.49  ? 731  GLN A CG  1 
ATOM   3462 C  CD  . GLN A 1 468 ? -11.308 -59.373 -16.368 1.00 29.32  ? 731  GLN A CD  1 
ATOM   3463 O  OE1 . GLN A 1 468 ? -11.562 -59.831 -17.479 1.00 28.02  ? 731  GLN A OE1 1 
ATOM   3464 N  NE2 . GLN A 1 468 ? -10.982 -60.135 -15.344 1.00 28.19  ? 731  GLN A NE2 1 
ATOM   3465 N  N   . ASP A 1 469 ? -9.115  -55.276 -13.679 1.00 31.35  ? 732  ASP A N   1 
ATOM   3466 C  CA  . ASP A 1 469 ? -9.282  -54.867 -12.254 1.00 34.18  ? 732  ASP A CA  1 
ATOM   3467 C  C   . ASP A 1 469 ? -10.059 -53.543 -12.207 1.00 33.28  ? 732  ASP A C   1 
ATOM   3468 O  O   . ASP A 1 469 ? -10.873 -53.382 -11.301 1.00 32.57  ? 732  ASP A O   1 
ATOM   3469 C  CB  . ASP A 1 469 ? -7.958  -54.800 -11.487 1.00 33.24  ? 732  ASP A CB  1 
ATOM   3470 C  CG  . ASP A 1 469 ? -7.295  -56.174 -11.314 1.00 41.15  ? 732  ASP A CG  1 
ATOM   3471 O  OD1 . ASP A 1 469 ? -7.989  -57.231 -11.473 1.00 40.15  ? 732  ASP A OD1 1 
ATOM   3472 O  OD2 . ASP A 1 469 ? -6.079  -56.192 -11.029 1.00 45.47  ? 732  ASP A OD2 1 
ATOM   3473 N  N   . GLU A 1 470 ? -9.809  -52.625 -13.132 1.00 30.05  ? 733  GLU A N   1 
ATOM   3474 C  CA  . GLU A 1 470 ? -10.502 -51.313 -13.174 1.00 32.51  ? 733  GLU A CA  1 
ATOM   3475 C  C   . GLU A 1 470 ? -11.999 -51.554 -13.483 1.00 31.40  ? 733  GLU A C   1 
ATOM   3476 O  O   . GLU A 1 470 ? -12.858 -50.920 -12.855 1.00 34.22  ? 733  GLU A O   1 
ATOM   3477 C  CB  . GLU A 1 470 ? -9.893  -50.386 -14.229 1.00 32.34  ? 733  GLU A CB  1 
ATOM   3478 C  CG  . GLU A 1 470 ? -8.366  -50.242 -14.142 1.00 39.80  ? 733  GLU A CG  1 
ATOM   3479 C  CD  . GLU A 1 470 ? -7.689  -49.296 -15.142 1.00 40.99  ? 733  GLU A CD  1 
ATOM   3480 O  OE1 . GLU A 1 470 ? -6.481  -49.117 -15.025 1.00 50.26  ? 733  GLU A OE1 1 
ATOM   3481 O  OE2 . GLU A 1 470 ? -8.362  -48.751 -16.056 1.00 47.03  ? 733  GLU A OE2 1 
ATOM   3482 N  N   . LEU A 1 471 ? -12.323 -52.418 -14.428 1.00 28.72  ? 734  LEU A N   1 
ATOM   3483 C  CA  . LEU A 1 471 ? -13.724 -52.651 -14.833 1.00 28.24  ? 734  LEU A CA  1 
ATOM   3484 C  C   . LEU A 1 471 ? -14.502 -53.309 -13.688 1.00 28.81  ? 734  LEU A C   1 
ATOM   3485 O  O   . LEU A 1 471 ? -15.613 -52.851 -13.371 1.00 26.49  ? 734  LEU A O   1 
ATOM   3486 C  CB  . LEU A 1 471 ? -13.736 -53.469 -16.116 1.00 28.11  ? 734  LEU A CB  1 
ATOM   3487 C  CG  . LEU A 1 471 ? -13.131 -52.724 -17.307 1.00 30.50  ? 734  LEU A CG  1 
ATOM   3488 C  CD1 . LEU A 1 471 ? -13.051 -53.632 -18.529 1.00 29.81  ? 734  LEU A CD1 1 
ATOM   3489 C  CD2 . LEU A 1 471 ? -13.927 -51.472 -17.627 1.00 31.14  ? 734  LEU A CD2 1 
ATOM   3490 N  N   . ILE A 1 472 ? -13.923 -54.290 -13.027 1.00 27.95  ? 735  ILE A N   1 
ATOM   3491 C  CA  . ILE A 1 472 ? -14.621 -54.985 -11.916 1.00 28.00  ? 735  ILE A CA  1 
ATOM   3492 C  C   . ILE A 1 472 ? -14.726 -54.092 -10.669 1.00 29.83  ? 735  ILE A C   1 
ATOM   3493 O  O   . ILE A 1 472 ? -15.803 -54.057 -10.075 1.00 28.77  ? 735  ILE A O   1 
ATOM   3494 C  CB  . ILE A 1 472 ? -13.928 -56.320 -11.664 1.00 27.39  ? 735  ILE A CB  1 
ATOM   3495 C  CG1 . ILE A 1 472 ? -14.119 -57.190 -12.905 1.00 27.53  ? 735  ILE A CG1 1 
ATOM   3496 C  CG2 . ILE A 1 472 ? -14.483 -56.935 -10.375 1.00 29.01  ? 735  ILE A CG2 1 
ATOM   3497 C  CD1 . ILE A 1 472 ? -13.498 -58.539 -12.808 1.00 31.63  ? 735  ILE A CD1 1 
ATOM   3498 N  N   . GLY A 1 473 ? -13.676 -53.342 -10.328 1.00 27.49  ? 736  GLY A N   1 
ATOM   3499 C  CA  . GLY A 1 473 ? -13.670 -52.398 -9.194  1.00 28.99  ? 736  GLY A CA  1 
ATOM   3500 C  C   . GLY A 1 473 ? -14.710 -51.289 -9.357  1.00 32.63  ? 736  GLY A C   1 
ATOM   3501 O  O   . GLY A 1 473 ? -15.416 -51.009 -8.354  1.00 31.15  ? 736  GLY A O   1 
ATOM   3502 N  N   . ARG A 1 474 ? -14.908 -50.760 -10.571 1.00 29.63  ? 737  ARG A N   1 
ATOM   3503 C  CA  . ARG A 1 474 ? -15.949 -49.709 -10.837 1.00 32.66  ? 737  ARG A CA  1 
ATOM   3504 C  C   . ARG A 1 474 ? -17.357 -50.303 -10.729 1.00 32.02  ? 737  ARG A C   1 
ATOM   3505 O  O   . ARG A 1 474 ? -18.217 -49.629 -10.140 1.00 36.60  ? 737  ARG A O   1 
ATOM   3506 C  CB  . ARG A 1 474 ? -15.798 -49.066 -12.224 1.00 37.91  ? 737  ARG A CB  1 
ATOM   3507 C  CG  . ARG A 1 474 ? -14.388 -48.565 -12.517 1.00 52.61  ? 737  ARG A CG  1 
ATOM   3508 C  CD  . ARG A 1 474 ? -13.985 -48.383 -13.995 1.00 58.27  ? 737  ARG A CD  1 
ATOM   3509 N  NE  . ARG A 1 474 ? -14.401 -47.036 -14.364 1.00 72.69  ? 737  ARG A NE  1 
ATOM   3510 C  CZ  . ARG A 1 474 ? -13.862 -45.908 -13.886 1.00 70.49  ? 737  ARG A CZ  1 
ATOM   3511 N  NH1 . ARG A 1 474 ? -14.377 -44.742 -14.241 1.00 73.84  ? 737  ARG A NH1 1 
ATOM   3512 N  NH2 . ARG A 1 474 ? -12.811 -45.944 -13.080 1.00 58.78  ? 737  ARG A NH2 1 
ATOM   3513 N  N   . ALA A 1 475 ? -17.613 -51.505 -11.260 1.00 29.16  ? 738  ALA A N   1 
ATOM   3514 C  CA  . ALA A 1 475 ? -18.960 -52.134 -11.218 1.00 27.88  ? 738  ALA A CA  1 
ATOM   3515 C  C   . ALA A 1 475 ? -19.329 -52.487 -9.779  1.00 27.55  ? 738  ALA A C   1 
ATOM   3516 O  O   . ALA A 1 475 ? -20.547 -52.645 -9.508  1.00 28.43  ? 738  ALA A O   1 
ATOM   3517 C  CB  . ALA A 1 475 ? -19.046 -53.369 -12.061 1.00 26.41  ? 738  ALA A CB  1 
ATOM   3518 N  N   . ARG A 1 476 ? -18.356 -52.585 -8.878  1.00 27.95  ? 739  ARG A N   1 
ATOM   3519 C  CA  . ARG A 1 476 ? -18.625 -52.938 -7.452  1.00 30.18  ? 739  ARG A CA  1 
ATOM   3520 C  C   . ARG A 1 476 ? -18.997 -51.711 -6.625  1.00 28.95  ? 739  ARG A C   1 
ATOM   3521 O  O   . ARG A 1 476 ? -19.306 -51.860 -5.430  1.00 31.43  ? 739  ARG A O   1 
ATOM   3522 C  CB  . ARG A 1 476 ? -17.469 -53.753 -6.862  1.00 28.73  ? 739  ARG A CB  1 
ATOM   3523 C  CG  . ARG A 1 476 ? -17.490 -55.193 -7.327  1.00 27.40  ? 739  ARG A CG  1 
ATOM   3524 C  CD  . ARG A 1 476 ? -16.147 -55.875 -7.167  1.00 30.02  ? 739  ARG A CD  1 
ATOM   3525 N  NE  . ARG A 1 476 ? -15.746 -56.146 -5.810  1.00 28.12  ? 739  ARG A NE  1 
ATOM   3526 C  CZ  . ARG A 1 476 ? -15.434 -57.343 -5.325  1.00 27.52  ? 739  ARG A CZ  1 
ATOM   3527 N  NH1 . ARG A 1 476 ? -15.574 -58.430 -6.037  1.00 28.36  ? 739  ARG A NH1 1 
ATOM   3528 N  NH2 . ARG A 1 476 ? -15.041 -57.461 -4.075  1.00 31.46  ? 739  ARG A NH2 1 
ATOM   3529 N  N   . ILE A 1 477 ? -19.043 -50.548 -7.237  1.00 31.25  ? 740  ILE A N   1 
ATOM   3530 C  CA  . ILE A 1 477 ? -19.295 -49.284 -6.505  1.00 42.82  ? 740  ILE A CA  1 
ATOM   3531 C  C   . ILE A 1 477 ? -20.623 -48.689 -6.979  1.00 48.03  ? 740  ILE A C   1 
ATOM   3532 O  O   . ILE A 1 477 ? -20.885 -48.693 -8.196  1.00 40.93  ? 740  ILE A O   1 
ATOM   3533 C  CB  . ILE A 1 477 ? -18.122 -48.299 -6.706  1.00 44.99  ? 740  ILE A CB  1 
ATOM   3534 C  CG1 . ILE A 1 477 ? -16.852 -48.754 -5.979  1.00 43.16  ? 740  ILE A CG1 1 
ATOM   3535 C  CG2 . ILE A 1 477 ? -18.540 -46.905 -6.270  1.00 45.68  ? 740  ILE A CG2 1 
ATOM   3536 C  CD1 . ILE A 1 477 ? -15.641 -47.910 -6.318  1.00 48.55  ? 740  ILE A CD1 1 
ATOM   3537 N  N   A SER A 1 478 ? -21.420 -48.202 -6.020  0.25 53.07  ? 741  SER A N   1 
ATOM   3538 N  N   B SER A 1 478 ? -21.446 -48.207 -6.038  0.25 51.50  ? 741  SER A N   1 
ATOM   3539 C  CA  A SER A 1 478 ? -22.657 -47.394 -6.214  0.25 59.60  ? 741  SER A CA  1 
ATOM   3540 C  CA  B SER A 1 478 ? -22.656 -47.375 -6.304  0.25 56.67  ? 741  SER A CA  1 
ATOM   3541 C  C   A SER A 1 478 ? -22.466 -45.996 -5.603  0.25 64.36  ? 741  SER A C   1 
ATOM   3542 C  C   B SER A 1 478 ? -22.548 -46.022 -5.583  0.25 62.68  ? 741  SER A C   1 
ATOM   3543 O  O   A SER A 1 478 ? -21.774 -45.891 -4.564  0.25 65.09  ? 741  SER A O   1 
ATOM   3544 O  O   B SER A 1 478 ? -22.021 -45.982 -4.448  0.25 64.01  ? 741  SER A O   1 
ATOM   3545 C  CB  A SER A 1 478 ? -23.846 -48.098 -5.609  0.25 58.91  ? 741  SER A CB  1 
ATOM   3546 C  CB  B SER A 1 478 ? -23.930 -48.100 -5.936  0.25 54.73  ? 741  SER A CB  1 
ATOM   3547 O  OG  A SER A 1 478 ? -25.009 -47.289 -5.682  0.25 61.36  ? 741  SER A OG  1 
ATOM   3548 O  OG  B SER A 1 478 ? -23.830 -48.726 -4.669  0.25 50.97  ? 741  SER A OG  1 
ATOM   3549 N  N   . GLN A 1 479 ? -23.038 -44.958 -6.227  1.00 70.81  ? 742  GLN A N   1 
ATOM   3550 C  CA  . GLN A 1 479 ? -23.034 -43.572 -5.664  1.00 77.92  ? 742  GLN A CA  1 
ATOM   3551 C  C   . GLN A 1 479 ? -24.315 -43.338 -4.840  1.00 77.55  ? 742  GLN A C   1 
ATOM   3552 O  O   . GLN A 1 479 ? -25.394 -43.837 -5.223  1.00 61.22  ? 742  GLN A O   1 
ATOM   3553 C  CB  . GLN A 1 479 ? -22.877 -42.519 -6.771  1.00 85.83  ? 742  GLN A CB  1 
ATOM   3554 C  CG  . GLN A 1 479 ? -21.458 -42.394 -7.330  1.00 98.08  ? 742  GLN A CG  1 
ATOM   3555 C  CD  . GLN A 1 479 ? -20.386 -42.206 -6.276  1.00 110.24 ? 742  GLN A CD  1 
ATOM   3556 O  OE1 . GLN A 1 479 ? -20.537 -41.411 -5.351  1.00 123.08 ? 742  GLN A OE1 1 
ATOM   3557 N  NE2 . GLN A 1 479 ? -19.276 -42.924 -6.407  1.00 113.60 ? 742  GLN A NE2 1 
ATOM   3558 N  N   . GLY A 1 480 ? -24.188 -42.614 -3.725  1.00 80.33  ? 743  GLY A N   1 
ATOM   3559 C  CA  . GLY A 1 480 ? -25.330 -42.038 -2.992  1.00 77.79  ? 743  GLY A CA  1 
ATOM   3560 C  C   . GLY A 1 480 ? -26.025 -43.046 -2.089  1.00 82.48  ? 743  GLY A C   1 
ATOM   3561 O  O   . GLY A 1 480 ? -25.690 -44.248 -2.123  1.00 78.97  ? 743  GLY A O   1 
ATOM   3562 N  N   . ALA A 1 481 ? -26.983 -42.547 -1.309  1.00 82.78  ? 744  ALA A N   1 
ATOM   3563 C  CA  . ALA A 1 481 ? -27.641 -43.253 -0.191  1.00 81.34  ? 744  ALA A CA  1 
ATOM   3564 C  C   . ALA A 1 481 ? -29.041 -43.685 -0.617  1.00 71.88  ? 744  ALA A C   1 
ATOM   3565 O  O   . ALA A 1 481 ? -29.539 -43.191 -1.641  1.00 61.17  ? 744  ALA A O   1 
ATOM   3566 C  CB  . ALA A 1 481 ? -27.708 -42.351 1.022   1.00 81.24  ? 744  ALA A CB  1 
ATOM   3567 N  N   . GLY A 1 482 ? -29.612 -44.598 0.162   1.00 63.88  ? 745  GLY A N   1 
ATOM   3568 C  CA  . GLY A 1 482 ? -31.036 -44.959 0.140   1.00 60.68  ? 745  GLY A CA  1 
ATOM   3569 C  C   . GLY A 1 482 ? -31.369 -45.976 -0.925  1.00 56.65  ? 745  GLY A C   1 
ATOM   3570 O  O   . GLY A 1 482 ? -32.534 -45.990 -1.298  1.00 57.83  ? 745  GLY A O   1 
ATOM   3571 N  N   . TRP A 1 483 ? -30.413 -46.764 -1.447  1.00 48.74  ? 746  TRP A N   1 
ATOM   3572 C  CA  . TRP A 1 483 ? -30.732 -47.691 -2.569  1.00 48.15  ? 746  TRP A CA  1 
ATOM   3573 C  C   . TRP A 1 483 ? -31.489 -48.908 -2.016  1.00 42.87  ? 746  TRP A C   1 
ATOM   3574 O  O   . TRP A 1 483 ? -31.019 -49.581 -1.092  1.00 41.44  ? 746  TRP A O   1 
ATOM   3575 C  CB  . TRP A 1 483 ? -29.510 -48.138 -3.366  1.00 53.18  ? 746  TRP A CB  1 
ATOM   3576 C  CG  . TRP A 1 483 ? -28.832 -47.053 -4.129  1.00 65.44  ? 746  TRP A CG  1 
ATOM   3577 C  CD1 . TRP A 1 483 ? -28.284 -45.912 -3.619  1.00 85.99  ? 746  TRP A CD1 1 
ATOM   3578 C  CD2 . TRP A 1 483 ? -28.547 -47.041 -5.533  1.00 60.89  ? 746  TRP A CD2 1 
ATOM   3579 N  NE1 . TRP A 1 483 ? -27.727 -45.164 -4.619  1.00 87.69  ? 746  TRP A NE1 1 
ATOM   3580 C  CE2 . TRP A 1 483 ? -27.877 -45.831 -5.805  1.00 76.04  ? 746  TRP A CE2 1 
ATOM   3581 C  CE3 . TRP A 1 483 ? -28.821 -47.912 -6.585  1.00 57.22  ? 746  TRP A CE3 1 
ATOM   3582 C  CZ2 . TRP A 1 483 ? -27.473 -45.479 -7.089  1.00 72.26  ? 746  TRP A CZ2 1 
ATOM   3583 C  CZ3 . TRP A 1 483 ? -28.442 -47.555 -7.857  1.00 62.85  ? 746  TRP A CZ3 1 
ATOM   3584 C  CH2 . TRP A 1 483 ? -27.781 -46.352 -8.104  1.00 67.37  ? 746  TRP A CH2 1 
ATOM   3585 N  N   . SER A 1 484 ? -32.605 -49.240 -2.631  1.00 37.56  ? 747  SER A N   1 
ATOM   3586 C  CA  . SER A 1 484 ? -33.270 -50.539 -2.390  1.00 38.88  ? 747  SER A CA  1 
ATOM   3587 C  C   . SER A 1 484 ? -32.402 -51.679 -2.979  1.00 33.20  ? 747  SER A C   1 
ATOM   3588 O  O   . SER A 1 484 ? -31.498 -51.396 -3.783  1.00 33.43  ? 747  SER A O   1 
ATOM   3589 C  CB  . SER A 1 484 ? -34.663 -50.472 -2.954  1.00 34.73  ? 747  SER A CB  1 
ATOM   3590 O  OG  . SER A 1 484 ? -34.611 -50.500 -4.373  1.00 34.55  ? 747  SER A OG  1 
ATOM   3591 N  N   . LEU A 1 485 ? -32.693 -52.939 -2.641  1.00 32.88  ? 748  LEU A N   1 
ATOM   3592 C  CA  . LEU A 1 485 ? -32.073 -54.143 -3.275  1.00 35.75  ? 748  LEU A CA  1 
ATOM   3593 C  C   . LEU A 1 485 ? -32.393 -54.168 -4.781  1.00 37.62  ? 748  LEU A C   1 
ATOM   3594 O  O   . LEU A 1 485 ? -31.517 -54.522 -5.612  1.00 35.59  ? 748  LEU A O   1 
ATOM   3595 C  CB  . LEU A 1 485 ? -32.627 -55.391 -2.592  1.00 36.53  ? 748  LEU A CB  1 
ATOM   3596 C  CG  . LEU A 1 485 ? -32.096 -56.718 -3.112  1.00 39.00  ? 748  LEU A CG  1 
ATOM   3597 C  CD1 . LEU A 1 485 ? -30.589 -56.656 -3.253  1.00 39.95  ? 748  LEU A CD1 1 
ATOM   3598 C  CD2 . LEU A 1 485 ? -32.509 -57.853 -2.184  1.00 37.06  ? 748  LEU A CD2 1 
ATOM   3599 N  N   . ARG A 1 486 ? -33.608 -53.766 -5.124  1.00 32.90  ? 749  ARG A N   1 
ATOM   3600 C  CA  . ARG A 1 486 ? -34.085 -53.729 -6.516  1.00 35.73  ? 749  ARG A CA  1 
ATOM   3601 C  C   . ARG A 1 486 ? -33.217 -52.745 -7.320  1.00 36.81  ? 749  ARG A C   1 
ATOM   3602 O  O   . ARG A 1 486 ? -32.724 -53.137 -8.407  1.00 36.71  ? 749  ARG A O   1 
ATOM   3603 C  CB  . ARG A 1 486 ? -35.574 -53.364 -6.544  1.00 33.45  ? 749  ARG A CB  1 
ATOM   3604 C  CG  . ARG A 1 486 ? -36.068 -53.203 -7.966  1.00 33.24  ? 749  ARG A CG  1 
ATOM   3605 C  CD  . ARG A 1 486 ? -37.538 -53.471 -8.031  1.00 37.29  ? 749  ARG A CD  1 
ATOM   3606 N  NE  . ARG A 1 486 ? -38.019 -53.329 -9.401  1.00 38.20  ? 749  ARG A NE  1 
ATOM   3607 C  CZ  . ARG A 1 486 ? -39.161 -53.831 -9.829  1.00 33.80  ? 749  ARG A CZ  1 
ATOM   3608 N  NH1 . ARG A 1 486 ? -39.909 -54.523 -9.007  1.00 35.66  ? 749  ARG A NH1 1 
ATOM   3609 N  NH2 . ARG A 1 486 ? -39.527 -53.702 -11.085 1.00 35.90  ? 749  ARG A NH2 1 
ATOM   3610 N  N   . GLU A 1 487 ? -33.054 -51.512 -6.838  1.00 34.23  ? 750  GLU A N   1 
ATOM   3611 C  CA  . GLU A 1 487 ? -32.243 -50.460 -7.521  1.00 41.42  ? 750  GLU A CA  1 
ATOM   3612 C  C   . GLU A 1 487 ? -30.766 -50.945 -7.669  1.00 39.73  ? 750  GLU A C   1 
ATOM   3613 O  O   . GLU A 1 487 ? -30.158 -50.842 -8.798  1.00 34.85  ? 750  GLU A O   1 
ATOM   3614 C  CB  . GLU A 1 487 ? -32.376 -49.134 -6.753  1.00 49.10  ? 750  GLU A CB  1 
ATOM   3615 C  CG  . GLU A 1 487 ? -32.717 -47.916 -7.613  1.00 72.96  ? 750  GLU A CG  1 
ATOM   3616 C  CD  . GLU A 1 487 ? -32.170 -46.540 -7.182  1.00 85.02  ? 750  GLU A CD  1 
ATOM   3617 O  OE1 . GLU A 1 487 ? -32.122 -46.266 -5.951  1.00 92.73  ? 750  GLU A OE1 1 
ATOM   3618 O  OE2 . GLU A 1 487 ? -31.796 -45.712 -8.088  1.00 71.40  ? 750  GLU A OE2 1 
ATOM   3619 N  N   . THR A 1 488 ? -30.190 -51.487 -6.600  1.00 36.18  ? 751  THR A N   1 
ATOM   3620 C  CA  . THR A 1 488 ? -28.829 -52.078 -6.592  1.00 32.17  ? 751  THR A CA  1 
ATOM   3621 C  C   . THR A 1 488 ? -28.725 -53.134 -7.702  1.00 33.49  ? 751  THR A C   1 
ATOM   3622 O  O   . THR A 1 488 ? -27.772 -53.053 -8.524  1.00 40.85  ? 751  THR A O   1 
ATOM   3623 C  CB  . THR A 1 488 ? -28.513 -52.659 -5.210  1.00 33.85  ? 751  THR A CB  1 
ATOM   3624 O  OG1 . THR A 1 488 ? -28.741 -51.625 -4.243  1.00 36.56  ? 751  THR A OG1 1 
ATOM   3625 C  CG2 . THR A 1 488 ? -27.093 -53.182 -5.119  1.00 32.77  ? 751  THR A CG2 1 
ATOM   3626 N  N   . ALA A 1 489 ? -29.641 -54.102 -7.743  1.00 32.60  ? 752  ALA A N   1 
ATOM   3627 C  CA  . ALA A 1 489 ? -29.666 -55.174 -8.772  1.00 31.97  ? 752  ALA A CA  1 
ATOM   3628 C  C   . ALA A 1 489 ? -29.702 -54.569 -10.191 1.00 32.24  ? 752  ALA A C   1 
ATOM   3629 O  O   . ALA A 1 489 ? -28.966 -55.071 -11.045 1.00 29.96  ? 752  ALA A O   1 
ATOM   3630 C  CB  . ALA A 1 489 ? -30.839 -56.092 -8.536  1.00 30.06  ? 752  ALA A CB  1 
ATOM   3631 N  N   . CYS A 1 490 ? -30.534 -53.546 -10.411 1.00 30.12  ? 753  CYS A N   1 
ATOM   3632 C  CA  . CYS A 1 490 ? -30.751 -52.869 -11.720 1.00 33.27  ? 753  CYS A CA  1 
ATOM   3633 C  C   . CYS A 1 490 ? -29.465 -52.118 -12.133 1.00 31.62  ? 753  CYS A C   1 
ATOM   3634 O  O   . CYS A 1 490 ? -29.127 -52.115 -13.316 1.00 28.21  ? 753  CYS A O   1 
ATOM   3635 C  CB  . CYS A 1 490 ? -31.974 -51.945 -11.678 1.00 34.20  ? 753  CYS A CB  1 
ATOM   3636 S  SG  . CYS A 1 490 ? -33.562 -52.862 -11.604 1.00 35.81  ? 753  CYS A SG  1 
ATOM   3637 N  N   . LEU A 1 491 ? -28.722 -51.554 -11.191 1.00 28.56  ? 754  LEU A N   1 
ATOM   3638 C  CA  . LEU A 1 491 ? -27.398 -50.969 -11.519 1.00 28.58  ? 754  LEU A CA  1 
ATOM   3639 C  C   . LEU A 1 491 ? -26.380 -52.073 -11.857 1.00 29.45  ? 754  LEU A C   1 
ATOM   3640 O  O   . LEU A 1 491 ? -25.649 -51.963 -12.882 1.00 33.97  ? 754  LEU A O   1 
ATOM   3641 C  CB  . LEU A 1 491 ? -26.959 -50.094 -10.336 1.00 32.47  ? 754  LEU A CB  1 
ATOM   3642 C  CG  . LEU A 1 491 ? -25.597 -49.425 -10.509 1.00 32.66  ? 754  LEU A CG  1 
ATOM   3643 C  CD1 . LEU A 1 491 ? -25.530 -48.519 -11.734 1.00 30.42  ? 754  LEU A CD1 1 
ATOM   3644 C  CD2 . LEU A 1 491 ? -25.166 -48.703 -9.239  1.00 33.77  ? 754  LEU A CD2 1 
ATOM   3645 N  N   . GLY A 1 492 ? -26.342 -53.159 -11.094 1.00 30.56  ? 755  GLY A N   1 
ATOM   3646 C  CA  . GLY A 1 492 ? -25.513 -54.323 -11.455 1.00 27.86  ? 755  GLY A CA  1 
ATOM   3647 C  C   . GLY A 1 492 ? -25.803 -54.793 -12.866 1.00 30.14  ? 755  GLY A C   1 
ATOM   3648 O  O   . GLY A 1 492 ? -24.853 -55.075 -13.657 1.00 27.59  ? 755  GLY A O   1 
ATOM   3649 N  N   . LYS A 1 493 ? -27.077 -54.806 -13.232 1.00 28.80  ? 756  LYS A N   1 
ATOM   3650 C  CA  . LYS A 1 493 ? -27.528 -55.242 -14.584 1.00 30.77  ? 756  LYS A CA  1 
ATOM   3651 C  C   . LYS A 1 493 ? -27.045 -54.248 -15.641 1.00 28.51  ? 756  LYS A C   1 
ATOM   3652 O  O   . LYS A 1 493 ? -26.707 -54.684 -16.747 1.00 30.82  ? 756  LYS A O   1 
ATOM   3653 C  CB  . LYS A 1 493 ? -29.054 -55.404 -14.588 1.00 29.46  ? 756  LYS A CB  1 
ATOM   3654 C  CG  . LYS A 1 493 ? -29.607 -55.927 -15.900 1.00 32.08  ? 756  LYS A CG  1 
ATOM   3655 C  CD  . LYS A 1 493 ? -31.035 -56.320 -15.788 1.00 33.68  ? 756  LYS A CD  1 
ATOM   3656 C  CE  . LYS A 1 493 ? -31.691 -56.651 -17.108 1.00 37.12  ? 756  LYS A CE  1 
ATOM   3657 N  NZ  . LYS A 1 493 ? -33.007 -57.291 -16.855 1.00 37.42  ? 756  LYS A NZ  1 
ATOM   3658 N  N   . SER A 1 494 ? -27.028 -52.947 -15.348 1.00 30.57  ? 757  SER A N   1 
ATOM   3659 C  CA  . SER A 1 494 ? -26.512 -51.940 -16.307 1.00 33.08  ? 757  SER A CA  1 
ATOM   3660 C  C   . SER A 1 494 ? -25.054 -52.274 -16.617 1.00 32.18  ? 757  SER A C   1 
ATOM   3661 O  O   . SER A 1 494 ? -24.714 -52.243 -17.788 1.00 30.18  ? 757  SER A O   1 
ATOM   3662 C  CB  . SER A 1 494 ? -26.600 -50.517 -15.821 1.00 36.37  ? 757  SER A CB  1 
ATOM   3663 O  OG  . SER A 1 494 ? -27.903 -50.227 -15.331 1.00 46.57  ? 757  SER A OG  1 
ATOM   3664 N  N   . TYR A 1 495 ? -24.231 -52.564 -15.605 1.00 29.13  ? 758  TYR A N   1 
ATOM   3665 C  CA  . TYR A 1 495 ? -22.783 -52.899 -15.818 1.00 33.79  ? 758  TYR A CA  1 
ATOM   3666 C  C   . TYR A 1 495 ? -22.646 -54.187 -16.654 1.00 31.37  ? 758  TYR A C   1 
ATOM   3667 O  O   . TYR A 1 495 ? -21.842 -54.242 -17.614 1.00 30.16  ? 758  TYR A O   1 
ATOM   3668 C  CB  . TYR A 1 495 ? -22.042 -52.998 -14.476 1.00 32.97  ? 758  TYR A CB  1 
ATOM   3669 C  CG  . TYR A 1 495 ? -21.582 -51.669 -13.951 1.00 33.99  ? 758  TYR A CG  1 
ATOM   3670 C  CD1 . TYR A 1 495 ? -20.478 -51.039 -14.526 1.00 32.16  ? 758  TYR A CD1 1 
ATOM   3671 C  CD2 . TYR A 1 495 ? -22.246 -51.034 -12.906 1.00 33.48  ? 758  TYR A CD2 1 
ATOM   3672 C  CE1 . TYR A 1 495 ? -20.072 -49.786 -14.110 1.00 29.05  ? 758  TYR A CE1 1 
ATOM   3673 C  CE2 . TYR A 1 495 ? -21.842 -49.779 -12.479 1.00 32.37  ? 758  TYR A CE2 1 
ATOM   3674 C  CZ  . TYR A 1 495 ? -20.737 -49.170 -13.065 1.00 36.40  ? 758  TYR A CZ  1 
ATOM   3675 O  OH  . TYR A 1 495 ? -20.338 -47.925 -12.661 1.00 33.84  ? 758  TYR A OH  1 
ATOM   3676 N  N   . ALA A 1 496 ? -23.434 -55.201 -16.297 1.00 31.61  ? 759  ALA A N   1 
ATOM   3677 C  CA  . ALA A 1 496 ? -23.430 -56.531 -16.933 1.00 29.53  ? 759  ALA A CA  1 
ATOM   3678 C  C   . ALA A 1 496 ? -23.746 -56.358 -18.424 1.00 31.96  ? 759  ALA A C   1 
ATOM   3679 O  O   . ALA A 1 496 ? -23.009 -56.908 -19.269 1.00 28.55  ? 759  ALA A O   1 
ATOM   3680 C  CB  . ALA A 1 496 ? -24.440 -57.404 -16.235 1.00 32.55  ? 759  ALA A CB  1 
ATOM   3681 N  N   . GLN A 1 497 ? -24.761 -55.560 -18.770 1.00 29.31  ? 760  GLN A N   1 
ATOM   3682 C  CA  . GLN A 1 497 ? -25.121 -55.386 -20.222 1.00 32.03  ? 760  GLN A CA  1 
ATOM   3683 C  C   . GLN A 1 497 ? -24.014 -54.562 -20.915 1.00 29.71  ? 760  GLN A C   1 
ATOM   3684 O  O   . GLN A 1 497 ? -23.708 -54.843 -22.102 1.00 30.16  ? 760  GLN A O   1 
ATOM   3685 C  CB  . GLN A 1 497 ? -26.542 -54.815 -20.405 1.00 33.63  ? 760  GLN A CB  1 
ATOM   3686 C  CG  . GLN A 1 497 ? -27.604 -55.669 -19.704 1.00 33.55  ? 760  GLN A CG  1 
ATOM   3687 C  CD  . GLN A 1 497 ? -29.042 -55.522 -20.159 1.00 35.64  ? 760  GLN A CD  1 
ATOM   3688 O  OE1 . GLN A 1 497 ? -29.765 -56.511 -20.212 1.00 38.42  ? 760  GLN A OE1 1 
ATOM   3689 N  NE2 . GLN A 1 497 ? -29.489 -54.309 -20.443 1.00 33.62  ? 760  GLN A NE2 1 
ATOM   3690 N  N   . MET A 1 498 ? -23.376 -53.616 -20.221 1.00 26.89  ? 761  MET A N   1 
ATOM   3691 C  CA  . MET A 1 498 ? -22.268 -52.852 -20.831 1.00 26.15  ? 761  MET A CA  1 
ATOM   3692 C  C   . MET A 1 498 ? -21.133 -53.830 -21.124 1.00 25.17  ? 761  MET A C   1 
ATOM   3693 O  O   . MET A 1 498 ? -20.547 -53.798 -22.225 1.00 27.37  ? 761  MET A O   1 
ATOM   3694 C  CB  . MET A 1 498 ? -21.769 -51.733 -19.932 1.00 30.41  ? 761  MET A CB  1 
ATOM   3695 C  CG  . MET A 1 498 ? -20.523 -51.038 -20.534 1.00 34.65  ? 761  MET A CG  1 
ATOM   3696 S  SD  . MET A 1 498 ? -19.921 -49.834 -19.401 1.00 42.02  ? 761  MET A SD  1 
ATOM   3697 C  CE  . MET A 1 498 ? -19.127 -50.866 -18.174 1.00 44.68  ? 761  MET A CE  1 
ATOM   3698 N  N   . TRP A 1 499 ? -20.844 -54.725 -20.201 1.00 26.53  ? 762  TRP A N   1 
ATOM   3699 C  CA  . TRP A 1 499 ? -19.730 -55.695 -20.406 1.00 27.08  ? 762  TRP A CA  1 
ATOM   3700 C  C   . TRP A 1 499 ? -20.055 -56.591 -21.615 1.00 31.02  ? 762  TRP A C   1 
ATOM   3701 O  O   . TRP A 1 499 ? -19.159 -56.831 -22.437 1.00 33.24  ? 762  TRP A O   1 
ATOM   3702 C  CB  . TRP A 1 499 ? -19.478 -56.525 -19.146 1.00 27.46  ? 762  TRP A CB  1 
ATOM   3703 C  CG  . TRP A 1 499 ? -18.933 -55.782 -17.972 1.00 25.83  ? 762  TRP A CG  1 
ATOM   3704 C  CD1 . TRP A 1 499 ? -18.388 -54.538 -17.962 1.00 26.37  ? 762  TRP A CD1 1 
ATOM   3705 C  CD2 . TRP A 1 499 ? -18.768 -56.300 -16.646 1.00 27.24  ? 762  TRP A CD2 1 
ATOM   3706 N  NE1 . TRP A 1 499 ? -17.998 -54.208 -16.700 1.00 28.53  ? 762  TRP A NE1 1 
ATOM   3707 C  CE2 . TRP A 1 499 ? -18.156 -55.289 -15.885 1.00 25.71  ? 762  TRP A CE2 1 
ATOM   3708 C  CE3 . TRP A 1 499 ? -19.078 -57.517 -16.026 1.00 28.16  ? 762  TRP A CE3 1 
ATOM   3709 C  CZ2 . TRP A 1 499 ? -17.842 -55.447 -14.538 1.00 27.15  ? 762  TRP A CZ2 1 
ATOM   3710 C  CZ3 . TRP A 1 499 ? -18.815 -57.657 -14.676 1.00 27.51  ? 762  TRP A CZ3 1 
ATOM   3711 C  CH2 . TRP A 1 499 ? -18.182 -56.647 -13.955 1.00 28.50  ? 762  TRP A CH2 1 
ATOM   3712 N  N   A SER A 1 500 ? -21.292 -57.087 -21.718 0.25 28.67  ? 763  SER A N   1 
ATOM   3713 N  N   B SER A 1 500 ? -21.303 -57.066 -21.719 0.23 30.45  ? 763  SER A N   1 
ATOM   3714 C  CA  A SER A 1 500 ? -21.719 -57.964 -22.838 0.25 28.60  ? 763  SER A CA  1 
ATOM   3715 C  CA  B SER A 1 500 ? -21.761 -57.960 -22.814 0.23 31.45  ? 763  SER A CA  1 
ATOM   3716 C  C   A SER A 1 500 ? -21.543 -57.221 -24.169 0.25 29.26  ? 763  SER A C   1 
ATOM   3717 C  C   B SER A 1 500 ? -21.631 -57.240 -24.167 0.23 30.94  ? 763  SER A C   1 
ATOM   3718 O  O   A SER A 1 500 ? -21.082 -57.848 -25.142 0.25 28.41  ? 763  SER A O   1 
ATOM   3719 O  O   B SER A 1 500 ? -21.306 -57.913 -25.168 0.23 30.39  ? 763  SER A O   1 
ATOM   3720 C  CB  A SER A 1 500 ? -23.124 -58.465 -22.651 0.25 28.04  ? 763  SER A CB  1 
ATOM   3721 C  CB  B SER A 1 500 ? -23.163 -58.483 -22.567 0.23 32.68  ? 763  SER A CB  1 
ATOM   3722 O  OG  A SER A 1 500 ? -23.264 -59.052 -21.373 0.25 27.24  ? 763  SER A OG  1 
ATOM   3723 O  OG  B SER A 1 500 ? -24.132 -57.446 -22.661 0.23 36.38  ? 763  SER A OG  1 
ATOM   3724 N  N   . LEU A 1 501 ? -21.836 -55.920 -24.195 1.00 31.06  ? 764  LEU A N   1 
ATOM   3725 C  CA  . LEU A 1 501 ? -21.748 -55.125 -25.448 1.00 32.91  ? 764  LEU A CA  1 
ATOM   3726 C  C   . LEU A 1 501 ? -20.313 -54.678 -25.782 1.00 31.77  ? 764  LEU A C   1 
ATOM   3727 O  O   . LEU A 1 501 ? -19.971 -54.625 -26.996 1.00 31.58  ? 764  LEU A O   1 
ATOM   3728 C  CB  . LEU A 1 501 ? -22.689 -53.934 -25.264 1.00 38.71  ? 764  LEU A CB  1 
ATOM   3729 C  CG  . LEU A 1 501 ? -23.262 -53.331 -26.537 1.00 50.14  ? 764  LEU A CG  1 
ATOM   3730 C  CD1 . LEU A 1 501 ? -23.594 -54.404 -27.571 1.00 54.95  ? 764  LEU A CD1 1 
ATOM   3731 C  CD2 . LEU A 1 501 ? -24.524 -52.540 -26.174 1.00 60.05  ? 764  LEU A CD2 1 
ATOM   3732 N  N   . MET A 1 502 ? -19.510 -54.272 -24.795 1.00 29.17  ? 765  MET A N   1 
ATOM   3733 C  CA  . MET A 1 502 ? -18.212 -53.586 -25.040 1.00 29.79  ? 765  MET A CA  1 
ATOM   3734 C  C   . MET A 1 502 ? -17.032 -54.537 -24.763 1.00 29.57  ? 765  MET A C   1 
ATOM   3735 O  O   . MET A 1 502 ? -16.064 -54.467 -25.489 1.00 29.40  ? 765  MET A O   1 
ATOM   3736 C  CB  . MET A 1 502 ? -18.087 -52.333 -24.161 1.00 34.09  ? 765  MET A CB  1 
ATOM   3737 C  CG  . MET A 1 502 ? -19.123 -51.230 -24.478 1.00 35.98  ? 765  MET A CG  1 
ATOM   3738 S  SD  . MET A 1 502 ? -18.975 -50.634 -26.200 1.00 42.39  ? 765  MET A SD  1 
ATOM   3739 C  CE  . MET A 1 502 ? -20.469 -51.229 -26.961 1.00 49.03  ? 765  MET A CE  1 
ATOM   3740 N  N   . TYR A 1 503 ? -17.131 -55.384 -23.748 1.00 26.87  ? 766  TYR A N   1 
ATOM   3741 C  CA  . TYR A 1 503 ? -16.014 -56.168 -23.183 1.00 29.03  ? 766  TYR A CA  1 
ATOM   3742 C  C   . TYR A 1 503 ? -16.324 -57.679 -23.278 1.00 29.99  ? 766  TYR A C   1 
ATOM   3743 O  O   . TYR A 1 503 ? -15.757 -58.436 -22.480 1.00 28.37  ? 766  TYR A O   1 
ATOM   3744 C  CB  . TYR A 1 503 ? -15.747 -55.683 -21.756 1.00 31.07  ? 766  TYR A CB  1 
ATOM   3745 C  CG  . TYR A 1 503 ? -15.552 -54.189 -21.602 1.00 31.15  ? 766  TYR A CG  1 
ATOM   3746 C  CD1 . TYR A 1 503 ? -14.487 -53.514 -22.182 1.00 30.16  ? 766  TYR A CD1 1 
ATOM   3747 C  CD2 . TYR A 1 503 ? -16.411 -53.437 -20.806 1.00 32.93  ? 766  TYR A CD2 1 
ATOM   3748 C  CE1 . TYR A 1 503 ? -14.322 -52.141 -22.008 1.00 29.41  ? 766  TYR A CE1 1 
ATOM   3749 C  CE2 . TYR A 1 503 ? -16.280 -52.063 -20.656 1.00 29.88  ? 766  TYR A CE2 1 
ATOM   3750 C  CZ  . TYR A 1 503 ? -15.220 -51.416 -21.246 1.00 30.48  ? 766  TYR A CZ  1 
ATOM   3751 O  OH  . TYR A 1 503 ? -15.103 -50.077 -21.039 1.00 32.13  ? 766  TYR A OH  1 
ATOM   3752 N  N   . PHE A 1 504 ? -17.130 -58.104 -24.273 1.00 28.31  ? 767  PHE A N   1 
ATOM   3753 C  CA  . PHE A 1 504 ? -17.530 -59.510 -24.541 1.00 29.82  ? 767  PHE A CA  1 
ATOM   3754 C  C   . PHE A 1 504 ? -16.305 -60.388 -24.805 1.00 31.91  ? 767  PHE A C   1 
ATOM   3755 O  O   . PHE A 1 504 ? -16.348 -61.619 -24.576 1.00 30.55  ? 767  PHE A O   1 
ATOM   3756 C  CB  . PHE A 1 504 ? -18.419 -59.645 -25.789 1.00 26.72  ? 767  PHE A CB  1 
ATOM   3757 C  CG  . PHE A 1 504 ? -17.919 -58.870 -26.984 1.00 25.37  ? 767  PHE A CG  1 
ATOM   3758 C  CD1 . PHE A 1 504 ? -18.319 -57.561 -27.206 1.00 27.24  ? 767  PHE A CD1 1 
ATOM   3759 C  CD2 . PHE A 1 504 ? -17.074 -59.444 -27.889 1.00 24.30  ? 767  PHE A CD2 1 
ATOM   3760 C  CE1 . PHE A 1 504 ? -17.810 -56.842 -28.274 1.00 26.35  ? 767  PHE A CE1 1 
ATOM   3761 C  CE2 . PHE A 1 504 ? -16.570 -58.735 -28.968 1.00 23.18  ? 767  PHE A CE2 1 
ATOM   3762 C  CZ  . PHE A 1 504 ? -16.957 -57.447 -29.166 1.00 28.82  ? 767  PHE A CZ  1 
ATOM   3763 N  N   . HIS A 1 505 ? -15.234 -59.773 -25.303 1.00 34.52  ? 768  HIS A N   1 
ATOM   3764 C  CA  . HIS A 1 505 ? -13.974 -60.472 -25.694 1.00 28.84  ? 768  HIS A CA  1 
ATOM   3765 C  C   . HIS A 1 505 ? -13.127 -60.825 -24.455 1.00 31.54  ? 768  HIS A C   1 
ATOM   3766 O  O   . HIS A 1 505 ? -12.069 -61.447 -24.638 1.00 32.00  ? 768  HIS A O   1 
ATOM   3767 C  CB  . HIS A 1 505 ? -13.220 -59.592 -26.679 1.00 25.40  ? 768  HIS A CB  1 
ATOM   3768 C  CG  . HIS A 1 505 ? -13.068 -58.196 -26.183 1.00 28.24  ? 768  HIS A CG  1 
ATOM   3769 N  ND1 . HIS A 1 505 ? -11.992 -57.801 -25.380 1.00 26.52  ? 768  HIS A ND1 1 
ATOM   3770 C  CD2 . HIS A 1 505 ? -13.871 -57.105 -26.333 1.00 31.68  ? 768  HIS A CD2 1 
ATOM   3771 C  CE1 . HIS A 1 505 ? -12.152 -56.526 -25.060 1.00 31.24  ? 768  HIS A CE1 1 
ATOM   3772 N  NE2 . HIS A 1 505 ? -13.296 -56.053 -25.658 1.00 30.65  ? 768  HIS A NE2 1 
ATOM   3773 N  N   . ARG A 1 506 ? -13.515 -60.394 -23.244 1.00 27.29  ? 769  ARG A N   1 
ATOM   3774 C  CA  . ARG A 1 506 ? -12.749 -60.695 -22.013 1.00 25.18  ? 769  ARG A CA  1 
ATOM   3775 C  C   . ARG A 1 506 ? -13.486 -61.879 -21.382 1.00 31.80  ? 769  ARG A C   1 
ATOM   3776 O  O   . ARG A 1 506 ? -14.686 -61.721 -21.123 1.00 29.87  ? 769  ARG A O   1 
ATOM   3777 C  CB  . ARG A 1 506 ? -12.701 -59.486 -21.062 1.00 27.34  ? 769  ARG A CB  1 
ATOM   3778 C  CG  . ARG A 1 506 ? -12.226 -58.172 -21.683 1.00 27.16  ? 769  ARG A CG  1 
ATOM   3779 C  CD  . ARG A 1 506 ? -10.891 -58.213 -22.408 1.00 27.89  ? 769  ARG A CD  1 
ATOM   3780 N  NE  . ARG A 1 506 ? -9.968  -58.728 -21.424 1.00 30.78  ? 769  ARG A NE  1 
ATOM   3781 C  CZ  . ARG A 1 506 ? -9.461  -58.068 -20.389 1.00 30.39  ? 769  ARG A CZ  1 
ATOM   3782 N  NH1 . ARG A 1 506 ? -8.788  -58.744 -19.474 1.00 29.13  ? 769  ARG A NH1 1 
ATOM   3783 N  NH2 . ARG A 1 506 ? -9.596  -56.764 -20.257 1.00 31.77  ? 769  ARG A NH2 1 
ATOM   3784 N  N   . ARG A 1 507 ? -12.838 -63.047 -21.263 1.00 30.08  ? 770  ARG A N   1 
ATOM   3785 C  CA  . ARG A 1 507 ? -13.463 -64.298 -20.795 1.00 28.64  ? 770  ARG A CA  1 
ATOM   3786 C  C   . ARG A 1 507 ? -14.190 -64.041 -19.486 1.00 28.31  ? 770  ARG A C   1 
ATOM   3787 O  O   . ARG A 1 507 ? -15.320 -64.519 -19.342 1.00 27.54  ? 770  ARG A O   1 
ATOM   3788 C  CB  . ARG A 1 507 ? -12.398 -65.378 -20.631 1.00 29.54  ? 770  ARG A CB  1 
ATOM   3789 C  CG  . ARG A 1 507 ? -11.944 -65.996 -21.950 1.00 32.78  ? 770  ARG A CG  1 
ATOM   3790 C  CD  . ARG A 1 507 ? -10.641 -66.792 -21.827 1.00 33.15  ? 770  ARG A CD  1 
ATOM   3791 N  NE  . ARG A 1 507 ? -10.258 -67.210 -23.159 1.00 30.75  ? 770  ARG A NE  1 
ATOM   3792 C  CZ  . ARG A 1 507 ? -9.702  -66.431 -24.072 1.00 34.17  ? 770  ARG A CZ  1 
ATOM   3793 N  NH1 . ARG A 1 507 ? -9.410  -65.177 -23.796 1.00 33.54  ? 770  ARG A NH1 1 
ATOM   3794 N  NH2 . ARG A 1 507 ? -9.422  -66.908 -25.272 1.00 36.53  ? 770  ARG A NH2 1 
ATOM   3795 N  N   . ASP A 1 508 ? -13.554 -63.349 -18.549 1.00 28.42  ? 771  ASP A N   1 
ATOM   3796 C  CA  . ASP A 1 508 ? -14.107 -63.228 -17.177 1.00 31.86  ? 771  ASP A CA  1 
ATOM   3797 C  C   . ASP A 1 508 ? -15.364 -62.323 -17.209 1.00 32.07  ? 771  ASP A C   1 
ATOM   3798 O  O   . ASP A 1 508 ? -16.300 -62.541 -16.410 1.00 29.91  ? 771  ASP A O   1 
ATOM   3799 C  CB  . ASP A 1 508 ? -13.061 -62.659 -16.222 1.00 31.60  ? 771  ASP A CB  1 
ATOM   3800 C  CG  . ASP A 1 508 ? -11.914 -63.589 -15.909 1.00 30.84  ? 771  ASP A CG  1 
ATOM   3801 O  OD1 . ASP A 1 508 ? -12.012 -64.793 -16.201 1.00 29.43  ? 771  ASP A OD1 1 
ATOM   3802 O  OD2 . ASP A 1 508 ? -10.929 -63.087 -15.357 1.00 32.20  ? 771  ASP A OD2 1 
ATOM   3803 N  N   . LEU A 1 509 ? -15.381 -61.300 -18.064 1.00 30.11  ? 772  LEU A N   1 
ATOM   3804 C  CA  . LEU A 1 509 ? -16.507 -60.334 -18.051 1.00 29.88  ? 772  LEU A CA  1 
ATOM   3805 C  C   . LEU A 1 509 ? -17.696 -60.944 -18.799 1.00 31.02  ? 772  LEU A C   1 
ATOM   3806 O  O   . LEU A 1 509 ? -18.833 -60.613 -18.448 1.00 33.23  ? 772  LEU A O   1 
ATOM   3807 C  CB  . LEU A 1 509 ? -16.049 -58.989 -18.622 1.00 27.67  ? 772  LEU A CB  1 
ATOM   3808 C  CG  . LEU A 1 509 ? -14.920 -58.296 -17.838 1.00 30.56  ? 772  LEU A CG  1 
ATOM   3809 C  CD1 . LEU A 1 509 ? -14.673 -56.890 -18.364 1.00 27.69  ? 772  LEU A CD1 1 
ATOM   3810 C  CD2 . LEU A 1 509 ? -15.180 -58.287 -16.322 1.00 28.73  ? 772  LEU A CD2 1 
ATOM   3811 N  N   . ARG A 1 510 ? -17.491 -61.806 -19.796 1.00 31.50  ? 773  ARG A N   1 
ATOM   3812 C  CA  . ARG A 1 510 ? -18.661 -62.406 -20.485 1.00 30.33  ? 773  ARG A CA  1 
ATOM   3813 C  C   . ARG A 1 510 ? -19.350 -63.339 -19.481 1.00 30.95  ? 773  ARG A C   1 
ATOM   3814 O  O   . ARG A 1 510 ? -20.580 -63.321 -19.364 1.00 30.59  ? 773  ARG A O   1 
ATOM   3815 C  CB  . ARG A 1 510 ? -18.270 -63.074 -21.796 1.00 31.52  ? 773  ARG A CB  1 
ATOM   3816 C  CG  . ARG A 1 510 ? -19.485 -63.338 -22.685 1.00 33.00  ? 773  ARG A CG  1 
ATOM   3817 C  CD  . ARG A 1 510 ? -19.209 -64.330 -23.798 1.00 32.01  ? 773  ARG A CD  1 
ATOM   3818 N  NE  . ARG A 1 510 ? -18.279 -63.784 -24.774 1.00 29.84  ? 773  ARG A NE  1 
ATOM   3819 C  CZ  . ARG A 1 510 ? -18.138 -64.214 -26.040 1.00 30.99  ? 773  ARG A CZ  1 
ATOM   3820 N  NH1 . ARG A 1 510 ? -18.888 -65.182 -26.514 1.00 34.91  ? 773  ARG A NH1 1 
ATOM   3821 N  NH2 . ARG A 1 510 ? -17.256 -63.668 -26.842 1.00 29.43  ? 773  ARG A NH2 1 
ATOM   3822 N  N   . LEU A 1 511 ? -18.578 -64.065 -18.694 1.00 30.87  ? 774  LEU A N   1 
ATOM   3823 C  CA  . LEU A 1 511 ? -19.127 -65.047 -17.740 1.00 30.56  ? 774  LEU A CA  1 
ATOM   3824 C  C   . LEU A 1 511 ? -19.828 -64.283 -16.623 1.00 30.73  ? 774  LEU A C   1 
ATOM   3825 O  O   . LEU A 1 511 ? -20.909 -64.715 -16.243 1.00 30.79  ? 774  LEU A O   1 
ATOM   3826 C  CB  . LEU A 1 511 ? -18.018 -65.953 -17.193 1.00 31.94  ? 774  LEU A CB  1 
ATOM   3827 C  CG  . LEU A 1 511 ? -18.480 -67.253 -16.531 1.00 32.98  ? 774  LEU A CG  1 
ATOM   3828 C  CD1 . LEU A 1 511 ? -17.369 -68.274 -16.517 1.00 34.85  ? 774  LEU A CD1 1 
ATOM   3829 C  CD2 . LEU A 1 511 ? -18.951 -67.010 -15.106 1.00 35.33  ? 774  LEU A CD2 1 
ATOM   3830 N  N   . ALA A 1 512 ? -19.224 -63.237 -16.077 1.00 27.98  ? 775  ALA A N   1 
ATOM   3831 C  CA  . ALA A 1 512 ? -19.803 -62.530 -14.924 1.00 28.38  ? 775  ALA A CA  1 
ATOM   3832 C  C   . ALA A 1 512 ? -21.070 -61.776 -15.397 1.00 30.69  ? 775  ALA A C   1 
ATOM   3833 O  O   . ALA A 1 512 ? -22.057 -61.766 -14.647 1.00 31.84  ? 775  ALA A O   1 
ATOM   3834 C  CB  . ALA A 1 512 ? -18.786 -61.610 -14.307 1.00 25.37  ? 775  ALA A CB  1 
ATOM   3835 N  N   . ALA A 1 513 ? -21.065 -61.207 -16.606 1.00 29.38  ? 776  ALA A N   1 
ATOM   3836 C  CA  . ALA A 1 513 ? -22.223 -60.485 -17.186 1.00 32.66  ? 776  ALA A CA  1 
ATOM   3837 C  C   . ALA A 1 513 ? -23.389 -61.480 -17.328 1.00 35.30  ? 776  ALA A C   1 
ATOM   3838 O  O   . ALA A 1 513 ? -24.534 -61.104 -16.958 1.00 33.26  ? 776  ALA A O   1 
ATOM   3839 C  CB  . ALA A 1 513 ? -21.871 -59.825 -18.509 1.00 28.62  ? 776  ALA A CB  1 
ATOM   3840 N  N   . ASN A 1 514 ? -23.109 -62.715 -17.771 1.00 31.00  ? 777  ASN A N   1 
ATOM   3841 C  CA  . ASN A 1 514 ? -24.153 -63.773 -17.903 1.00 33.66  ? 777  ASN A CA  1 
ATOM   3842 C  C   . ASN A 1 514 ? -24.688 -64.149 -16.524 1.00 32.80  ? 777  ASN A C   1 
ATOM   3843 O  O   . ASN A 1 514 ? -25.927 -64.228 -16.352 1.00 35.01  ? 777  ASN A O   1 
ATOM   3844 C  CB  . ASN A 1 514 ? -23.636 -64.990 -18.656 1.00 34.99  ? 777  ASN A CB  1 
ATOM   3845 C  CG  . ASN A 1 514 ? -23.575 -64.697 -20.142 1.00 38.35  ? 777  ASN A CG  1 
ATOM   3846 O  OD1 . ASN A 1 514 ? -24.382 -63.929 -20.654 1.00 35.34  ? 777  ASN A OD1 1 
ATOM   3847 N  ND2 . ASN A 1 514 ? -22.617 -65.286 -20.834 1.00 34.90  ? 777  ASN A ND2 1 
ATOM   3848 N  N   . ALA A 1 515 ? -23.805 -64.307 -15.555 1.00 29.96  ? 778  ALA A N   1 
ATOM   3849 C  CA  . ALA A 1 515 ? -24.194 -64.615 -14.164 1.00 28.08  ? 778  ALA A CA  1 
ATOM   3850 C  C   . ALA A 1 515 ? -25.077 -63.502 -13.605 1.00 28.92  ? 778  ALA A C   1 
ATOM   3851 O  O   . ALA A 1 515 ? -26.065 -63.808 -12.979 1.00 31.73  ? 778  ALA A O   1 
ATOM   3852 C  CB  . ALA A 1 515 ? -22.960 -64.793 -13.321 1.00 26.37  ? 778  ALA A CB  1 
ATOM   3853 N  N   . ILE A 1 516 ? -24.691 -62.233 -13.746 1.00 32.64  ? 779  ILE A N   1 
ATOM   3854 C  CA  . ILE A 1 516 ? -25.470 -61.096 -13.172 1.00 31.61  ? 779  ILE A CA  1 
ATOM   3855 C  C   . ILE A 1 516 ? -26.841 -61.040 -13.872 1.00 33.51  ? 779  ILE A C   1 
ATOM   3856 O  O   . ILE A 1 516 ? -27.818 -60.846 -13.182 1.00 27.43  ? 779  ILE A O   1 
ATOM   3857 C  CB  . ILE A 1 516 ? -24.733 -59.752 -13.307 1.00 30.86  ? 779  ILE A CB  1 
ATOM   3858 C  CG1 . ILE A 1 516 ? -23.453 -59.718 -12.475 1.00 32.26  ? 779  ILE A CG1 1 
ATOM   3859 C  CG2 . ILE A 1 516 ? -25.650 -58.566 -12.967 1.00 27.81  ? 779  ILE A CG2 1 
ATOM   3860 C  CD1 . ILE A 1 516 ? -22.496 -58.624 -12.924 1.00 32.42  ? 779  ILE A CD1 1 
ATOM   3861 N  N   . CYS A 1 517 ? -26.901 -61.165 -15.197 1.00 31.25  ? 780  CYS A N   1 
ATOM   3862 C  CA  . CYS A 1 517 ? -28.188 -61.134 -15.933 1.00 36.52  ? 780  CYS A CA  1 
ATOM   3863 C  C   . CYS A 1 517 ? -29.046 -62.364 -15.579 1.00 38.98  ? 780  CYS A C   1 
ATOM   3864 O  O   . CYS A 1 517 ? -30.238 -62.254 -15.672 1.00 35.11  ? 780  CYS A O   1 
ATOM   3865 C  CB  . CYS A 1 517 ? -27.972 -60.988 -17.430 1.00 32.72  ? 780  CYS A CB  1 
ATOM   3866 S  SG  . CYS A 1 517 ? -27.328 -59.345 -17.792 1.00 37.15  ? 780  CYS A SG  1 
ATOM   3867 N  N   . SER A 1 518 ? -28.457 -63.461 -15.113 1.00 36.93  ? 781  SER A N   1 
ATOM   3868 C  CA  . SER A 1 518 ? -29.200 -64.658 -14.669 1.00 34.65  ? 781  SER A CA  1 
ATOM   3869 C  C   . SER A 1 518 ? -29.724 -64.416 -13.254 1.00 33.96  ? 781  SER A C   1 
ATOM   3870 O  O   . SER A 1 518 ? -30.671 -65.098 -12.860 1.00 32.27  ? 781  SER A O   1 
ATOM   3871 C  CB  . SER A 1 518 ? -28.337 -65.917 -14.714 1.00 31.96  ? 781  SER A CB  1 
ATOM   3872 O  OG  . SER A 1 518 ? -27.959 -66.237 -16.043 1.00 34.58  ? 781  SER A OG  1 
ATOM   3873 N  N   . ALA A 1 519 ? -29.116 -63.504 -12.503 1.00 31.92  ? 782  ALA A N   1 
ATOM   3874 C  CA  . ALA A 1 519 ? -29.345 -63.386 -11.044 1.00 35.03  ? 782  ALA A CA  1 
ATOM   3875 C  C   . ALA A 1 519 ? -30.332 -62.251 -10.766 1.00 31.32  ? 782  ALA A C   1 
ATOM   3876 O  O   . ALA A 1 519 ? -30.864 -62.216 -9.699  1.00 36.12  ? 782  ALA A O   1 
ATOM   3877 C  CB  . ALA A 1 519 ? -28.033 -63.213 -10.286 1.00 38.72  ? 782  ALA A CB  1 
ATOM   3878 N  N   . VAL A 1 520 ? -30.532 -61.385 -11.748 1.00 31.73  ? 783  VAL A N   1 
ATOM   3879 C  CA  . VAL A 1 520 ? -31.489 -60.256 -11.627 1.00 33.20  ? 783  VAL A CA  1 
ATOM   3880 C  C   . VAL A 1 520 ? -32.742 -60.599 -12.444 1.00 34.13  ? 783  VAL A C   1 
ATOM   3881 O  O   . VAL A 1 520 ? -32.601 -61.105 -13.558 1.00 31.37  ? 783  VAL A O   1 
ATOM   3882 C  CB  . VAL A 1 520 ? -30.838 -58.948 -12.109 1.00 34.75  ? 783  VAL A CB  1 
ATOM   3883 C  CG1 . VAL A 1 520 ? -31.812 -57.782 -12.090 1.00 33.97  ? 783  VAL A CG1 1 
ATOM   3884 C  CG2 . VAL A 1 520 ? -29.577 -58.617 -11.327 1.00 30.42  ? 783  VAL A CG2 1 
ATOM   3885 N  N   . PRO A 1 521 ? -33.962 -60.367 -11.911 1.00 33.42  ? 784  PRO A N   1 
ATOM   3886 C  CA  . PRO A 1 521 ? -35.190 -60.652 -12.651 1.00 33.54  ? 784  PRO A CA  1 
ATOM   3887 C  C   . PRO A 1 521 ? -35.025 -60.239 -14.118 1.00 33.53  ? 784  PRO A C   1 
ATOM   3888 O  O   . PRO A 1 521 ? -34.808 -59.075 -14.326 1.00 34.38  ? 784  PRO A O   1 
ATOM   3889 C  CB  . PRO A 1 521 ? -36.246 -59.916 -11.822 1.00 34.60  ? 784  PRO A CB  1 
ATOM   3890 C  CG  . PRO A 1 521 ? -35.739 -60.059 -10.414 1.00 34.43  ? 784  PRO A CG  1 
ATOM   3891 C  CD  . PRO A 1 521 ? -34.245 -59.874 -10.557 1.00 35.38  ? 784  PRO A CD  1 
ATOM   3892 N  N   A SER A 1 522 ? -35.505 -61.074 -15.043 0.25 34.18  ? 785  SER A N   1 
ATOM   3893 N  N   B SER A 1 522 ? -35.509 -61.073 -15.042 0.25 33.74  ? 785  SER A N   1 
ATOM   3894 C  CA  A SER A 1 522 ? -35.326 -60.792 -16.494 0.25 36.73  ? 785  SER A CA  1 
ATOM   3895 C  CA  B SER A 1 522 ? -35.329 -60.793 -16.493 0.25 35.95  ? 785  SER A CA  1 
ATOM   3896 C  C   A SER A 1 522 ? -35.944 -59.461 -16.930 0.25 37.15  ? 785  SER A C   1 
ATOM   3897 C  C   B SER A 1 522 ? -35.943 -59.460 -16.927 0.25 36.51  ? 785  SER A C   1 
ATOM   3898 O  O   A SER A 1 522 ? -35.444 -58.897 -17.917 0.25 36.37  ? 785  SER A O   1 
ATOM   3899 O  O   B SER A 1 522 ? -35.442 -58.898 -17.915 0.25 36.02  ? 785  SER A O   1 
ATOM   3900 C  CB  A SER A 1 522 ? -35.889 -61.930 -17.303 0.25 39.94  ? 785  SER A CB  1 
ATOM   3901 C  CB  B SER A 1 522 ? -35.917 -61.922 -17.293 0.25 38.50  ? 785  SER A CB  1 
ATOM   3902 O  OG  A SER A 1 522 ? -37.262 -62.126 -17.006 0.25 43.26  ? 785  SER A OG  1 
ATOM   3903 O  OG  B SER A 1 522 ? -35.636 -63.170 -16.678 0.25 39.98  ? 785  SER A OG  1 
ATOM   3904 N  N   . HIS A 1 523 ? -37.126 -59.124 -16.408 0.50 37.11  ? 786  HIS A N   1 
ATOM   3905 C  CA  . HIS A 1 523 ? -37.824 -57.885 -16.864 0.50 38.39  ? 786  HIS A CA  1 
ATOM   3906 C  C   . HIS A 1 523 ? -37.448 -56.615 -16.086 0.50 37.33  ? 786  HIS A C   1 
ATOM   3907 O  O   . HIS A 1 523 ? -37.915 -55.542 -16.495 0.50 38.81  ? 786  HIS A O   1 
ATOM   3908 C  CB  . HIS A 1 523 ? -39.337 -58.144 -16.874 0.50 40.89  ? 786  HIS A CB  1 
ATOM   3909 C  CG  . HIS A 1 523 ? -39.737 -59.222 -17.821 0.50 42.49  ? 786  HIS A CG  1 
ATOM   3910 N  ND1 . HIS A 1 523 ? -39.887 -60.534 -17.424 0.50 43.89  ? 786  HIS A ND1 1 
ATOM   3911 C  CD2 . HIS A 1 523 ? -40.002 -59.194 -19.144 0.50 44.91  ? 786  HIS A CD2 1 
ATOM   3912 C  CE1 . HIS A 1 523 ? -40.236 -61.268 -18.460 0.50 45.39  ? 786  HIS A CE1 1 
ATOM   3913 N  NE2 . HIS A 1 523 ? -40.313 -60.469 -19.527 0.50 44.47  ? 786  HIS A NE2 1 
ATOM   3914 N  N   . TRP A 1 524 ? -36.627 -56.716 -15.041 1.00 35.70  ? 787  TRP A N   1 
ATOM   3915 C  CA  . TRP A 1 524 ? -36.193 -55.498 -14.307 1.00 35.03  ? 787  TRP A CA  1 
ATOM   3916 C  C   . TRP A 1 524 ? -35.331 -54.618 -15.218 1.00 35.36  ? 787  TRP A C   1 
ATOM   3917 O  O   . TRP A 1 524 ? -34.438 -55.150 -15.872 1.00 36.40  ? 787  TRP A O   1 
ATOM   3918 C  CB  . TRP A 1 524 ? -35.536 -55.846 -12.969 1.00 38.56  ? 787  TRP A CB  1 
ATOM   3919 C  CG  . TRP A 1 524 ? -36.521 -56.327 -11.948 1.00 39.52  ? 787  TRP A CG  1 
ATOM   3920 C  CD1 . TRP A 1 524 ? -37.837 -56.615 -12.157 1.00 38.82  ? 787  TRP A CD1 1 
ATOM   3921 C  CD2 . TRP A 1 524 ? -36.277 -56.576 -10.553 1.00 36.18  ? 787  TRP A CD2 1 
ATOM   3922 N  NE1 . TRP A 1 524 ? -38.426 -57.026 -10.994 1.00 37.39  ? 787  TRP A NE1 1 
ATOM   3923 C  CE2 . TRP A 1 524 ? -37.496 -57.010 -9.992  1.00 34.89  ? 787  TRP A CE2 1 
ATOM   3924 C  CE3 . TRP A 1 524 ? -35.154 -56.476 -9.726  1.00 35.81  ? 787  TRP A CE3 1 
ATOM   3925 C  CZ2 . TRP A 1 524 ? -37.619 -57.346 -8.646  1.00 35.42  ? 787  TRP A CZ2 1 
ATOM   3926 C  CZ3 . TRP A 1 524 ? -35.278 -56.806 -8.396  1.00 39.30  ? 787  TRP A CZ3 1 
ATOM   3927 C  CH2 . TRP A 1 524 ? -36.493 -57.234 -7.866  1.00 38.06  ? 787  TRP A CH2 1 
ATOM   3928 N  N   . VAL A 1 525 ? -35.611 -53.318 -15.249 0.50 36.37  ? 788  VAL A N   1 
ATOM   3929 C  CA  . VAL A 1 525 ? -34.923 -52.419 -16.220 0.50 39.57  ? 788  VAL A CA  1 
ATOM   3930 C  C   . VAL A 1 525 ? -33.597 -51.896 -15.665 0.50 40.96  ? 788  VAL A C   1 
ATOM   3931 O  O   . VAL A 1 525 ? -33.565 -51.467 -14.502 0.50 39.29  ? 788  VAL A O   1 
ATOM   3932 C  CB  . VAL A 1 525 ? -35.851 -51.259 -16.634 0.50 39.88  ? 788  VAL A CB  1 
ATOM   3933 C  CG1 . VAL A 1 525 ? -35.159 -50.279 -17.567 0.50 39.93  ? 788  VAL A CG1 1 
ATOM   3934 C  CG2 . VAL A 1 525 ? -37.146 -51.764 -17.248 0.50 39.15  ? 788  VAL A CG2 1 
ATOM   3935 N  N   . PRO A 1 526 ? -32.507 -51.919 -16.460 0.50 43.52  ? 789  PRO A N   1 
ATOM   3936 C  CA  . PRO A 1 526 ? -31.233 -51.323 -16.055 0.50 43.14  ? 789  PRO A CA  1 
ATOM   3937 C  C   . PRO A 1 526 ? -31.376 -49.832 -15.721 0.50 44.67  ? 789  PRO A C   1 
ATOM   3938 O  O   . PRO A 1 526 ? -32.074 -49.149 -16.464 0.50 43.87  ? 789  PRO A O   1 
ATOM   3939 C  CB  . PRO A 1 526 ? -30.345 -51.480 -17.296 0.50 44.57  ? 789  PRO A CB  1 
ATOM   3940 C  CG  . PRO A 1 526 ? -30.969 -52.612 -18.083 0.50 43.54  ? 789  PRO A CG  1 
ATOM   3941 C  CD  . PRO A 1 526 ? -32.450 -52.531 -17.795 0.50 43.92  ? 789  PRO A CD  1 
ATOM   3942 N  N   . THR A 1 527 ? -30.714 -49.371 -14.652 0.40 47.70  ? 790  THR A N   1 
ATOM   3943 C  CA  . THR A 1 527 ? -30.851 -47.995 -14.103 0.40 54.86  ? 790  THR A CA  1 
ATOM   3944 C  C   . THR A 1 527 ? -29.491 -47.334 -13.871 0.40 57.23  ? 790  THR A C   1 
ATOM   3945 O  O   . THR A 1 527 ? -28.469 -48.032 -13.955 0.40 56.88  ? 790  THR A O   1 
ATOM   3946 C  CB  . THR A 1 527 ? -31.595 -47.989 -12.765 0.40 58.14  ? 790  THR A CB  1 
ATOM   3947 O  OG1 . THR A 1 527 ? -30.822 -48.746 -11.830 0.40 61.33  ? 790  THR A OG1 1 
ATOM   3948 C  CG2 . THR A 1 527 ? -32.997 -48.541 -12.884 0.40 60.50  ? 790  THR A CG2 1 
ATOM   3949 N  N   . SER A 1 528 ? -29.526 -46.033 -13.558 0.40 65.15  ? 791  SER A N   1 
ATOM   3950 C  CA  . SER A 1 528 ? -28.371 -45.148 -13.256 0.40 71.59  ? 791  SER A CA  1 
ATOM   3951 C  C   . SER A 1 528 ? -27.489 -45.001 -14.498 0.40 76.60  ? 791  SER A C   1 
ATOM   3952 O  O   . SER A 1 528 ? -28.021 -45.090 -15.619 0.40 80.06  ? 791  SER A O   1 
ATOM   3953 C  CB  . SER A 1 528 ? -27.589 -45.664 -12.081 0.40 75.40  ? 791  SER A CB  1 
ATOM   3954 O  OG  . SER A 1 528 ? -26.440 -44.862 -11.831 0.40 77.92  ? 791  SER A OG  1 
ATOM   3955 N  N   . ARG A 1 529 ? -26.192 -44.769 -14.293 0.40 83.64  ? 792  ARG A N   1 
ATOM   3956 C  CA  . ARG A 1 529 ? -25.178 -44.649 -15.372 0.40 91.04  ? 792  ARG A CA  1 
ATOM   3957 C  C   . ARG A 1 529 ? -23.961 -45.505 -15.004 0.40 93.61  ? 792  ARG A C   1 
ATOM   3958 O  O   . ARG A 1 529 ? -23.422 -45.324 -13.887 0.40 93.60  ? 792  ARG A O   1 
ATOM   3959 C  CB  . ARG A 1 529 ? -24.783 -43.183 -15.578 0.40 94.59  ? 792  ARG A CB  1 
ATOM   3960 C  CG  . ARG A 1 529 ? -25.491 -42.495 -16.737 0.40 96.93  ? 792  ARG A CG  1 
ATOM   3961 C  CD  . ARG A 1 529 ? -25.086 -41.037 -16.856 0.40 99.41  ? 792  ARG A CD  1 
ATOM   3962 N  NE  . ARG A 1 529 ? -25.587 -40.422 -18.077 0.40 101.85 ? 792  ARG A NE  1 
ATOM   3963 C  CZ  . ARG A 1 529 ? -24.889 -40.304 -19.202 0.40 104.92 ? 792  ARG A CZ  1 
ATOM   3964 N  NH1 . ARG A 1 529 ? -25.432 -39.731 -20.262 0.40 107.17 ? 792  ARG A NH1 1 
ATOM   3965 N  NH2 . ARG A 1 529 ? -23.650 -40.756 -19.263 0.40 105.79 ? 792  ARG A NH2 1 
ATOM   3966 N  N   . THR A 1 530 ? -23.567 -46.414 -15.903 0.40 90.36  ? 793  THR A N   1 
ATOM   3967 C  CA  . THR A 1 530 ? -22.304 -47.190 -15.829 0.40 88.31  ? 793  THR A CA  1 
ATOM   3968 C  C   . THR A 1 530 ? -21.126 -46.227 -16.022 0.40 94.21  ? 793  THR A C   1 
ATOM   3969 O  O   . THR A 1 530 ? -20.049 -46.478 -15.441 0.40 99.85  ? 793  THR A O   1 
ATOM   3970 C  CB  . THR A 1 530 ? -22.290 -48.309 -16.875 0.40 84.23  ? 793  THR A CB  1 
ATOM   3971 O  OG1 . THR A 1 530 ? -22.337 -47.684 -18.156 0.40 87.70  ? 793  THR A OG1 1 
ATOM   3972 C  CG2 . THR A 1 530 ? -23.446 -49.273 -16.729 0.40 83.46  ? 793  THR A CG2 1 
ATOM   3973 N  N   . THR A 1 531 ? -21.339 -45.162 -16.802 0.40 97.34  ? 794  THR A N   1 
ATOM   3974 C  CA  . THR A 1 531 ? -20.331 -44.116 -17.131 0.40 99.08  ? 794  THR A CA  1 
ATOM   3975 C  C   . THR A 1 531 ? -21.064 -42.810 -17.471 0.40 98.76  ? 794  THR A C   1 
ATOM   3976 O  O   . THR A 1 531 ? -22.289 -42.867 -17.697 0.40 96.92  ? 794  THR A O   1 
ATOM   3977 C  CB  . THR A 1 531 ? -19.402 -44.603 -18.254 0.40 98.28  ? 794  THR A CB  1 
ATOM   3978 O  OG1 . THR A 1 531 ? -18.401 -43.615 -18.496 0.40 100.69 ? 794  THR A OG1 1 
ATOM   3979 C  CG2 . THR A 1 531 ? -20.137 -44.902 -19.543 0.40 96.87  ? 794  THR A CG2 1 
ATOM   3980 N  N   . TRP A 1 532 ? -20.343 -41.682 -17.483 0.40 103.81 ? 795  TRP A N   1 
ATOM   3981 C  CA  . TRP A 1 532 ? -20.873 -40.326 -17.803 0.40 105.50 ? 795  TRP A CA  1 
ATOM   3982 C  C   . TRP A 1 532 ? -20.095 -39.730 -18.984 0.40 102.64 ? 795  TRP A C   1 
ATOM   3983 O  O   . TRP A 1 532 ? -20.442 -38.609 -19.410 0.40 103.91 ? 795  TRP A O   1 
ATOM   3984 C  CB  . TRP A 1 532 ? -20.816 -39.411 -16.570 0.40 106.41 ? 795  TRP A CB  1 
ATOM   3985 C  CG  . TRP A 1 532 ? -21.804 -39.765 -15.501 0.40 109.09 ? 795  TRP A CG  1 
ATOM   3986 C  CD1 . TRP A 1 532 ? -22.989 -39.141 -15.236 0.40 108.18 ? 795  TRP A CD1 1 
ATOM   3987 C  CD2 . TRP A 1 532 ? -21.697 -40.839 -14.550 0.40 112.80 ? 795  TRP A CD2 1 
ATOM   3988 N  NE1 . TRP A 1 532 ? -23.623 -39.749 -14.186 0.40 108.82 ? 795  TRP A NE1 1 
ATOM   3989 C  CE2 . TRP A 1 532 ? -22.855 -40.795 -13.745 0.40 112.50 ? 795  TRP A CE2 1 
ATOM   3990 C  CE3 . TRP A 1 532 ? -20.739 -41.830 -14.301 0.40 114.47 ? 795  TRP A CE3 1 
ATOM   3991 C  CZ2 . TRP A 1 532 ? -23.077 -41.704 -12.711 0.40 115.31 ? 795  TRP A CZ2 1 
ATOM   3992 C  CZ3 . TRP A 1 532 ? -20.959 -42.727 -13.279 0.40 116.18 ? 795  TRP A CZ3 1 
ATOM   3993 C  CH2 . TRP A 1 532 ? -22.113 -42.663 -12.496 0.40 118.00 ? 795  TRP A CH2 1 
ATOM   3994 N  N   . SER A 1 533 ? -19.088 -40.456 -19.485 0.40 98.49  ? 796  SER A N   1 
ATOM   3995 C  CA  . SER A 1 533 ? -18.231 -40.061 -20.636 0.40 92.45  ? 796  SER A CA  1 
ATOM   3996 C  C   . SER A 1 533 ? -19.115 -39.572 -21.790 0.40 86.77  ? 796  SER A C   1 
ATOM   3997 O  O   . SER A 1 533 ? -20.005 -40.338 -22.216 0.40 88.89  ? 796  SER A O   1 
ATOM   3998 C  CB  . SER A 1 533 ? -17.342 -41.202 -21.067 0.40 90.35  ? 796  SER A CB  1 
ATOM   3999 O  OG  . SER A 1 533 ? -16.422 -41.544 -20.040 0.40 88.48  ? 796  SER A OG  1 
ATOM   4000 N  N   . ILE A 1 534 ? -18.864 -38.350 -22.275 0.40 78.17  ? 797  ILE A N   1 
ATOM   4001 C  CA  . ILE A 1 534 ? -19.704 -37.641 -23.288 0.40 74.31  ? 797  ILE A CA  1 
ATOM   4002 C  C   . ILE A 1 534 ? -19.535 -38.314 -24.657 0.40 71.12  ? 797  ILE A C   1 
ATOM   4003 O  O   . ILE A 1 534 ? -20.399 -38.100 -25.533 0.40 70.95  ? 797  ILE A O   1 
ATOM   4004 C  CB  . ILE A 1 534 ? -19.357 -36.140 -23.337 0.40 74.56  ? 797  ILE A CB  1 
ATOM   4005 C  CG1 . ILE A 1 534 ? -19.223 -35.535 -21.935 0.40 76.77  ? 797  ILE A CG1 1 
ATOM   4006 C  CG2 . ILE A 1 534 ? -20.372 -35.385 -24.179 0.40 73.96  ? 797  ILE A CG2 1 
ATOM   4007 C  CD1 . ILE A 1 534 ? -20.522 -35.442 -21.164 0.40 75.34  ? 797  ILE A CD1 1 
ATOM   4008 N  N   . HIS A 1 535 ? -18.472 -39.105 -24.838 0.40 68.22  ? 798  HIS A N   1 
ATOM   4009 C  CA  . HIS A 1 535 ? -18.251 -39.937 -26.053 0.40 64.02  ? 798  HIS A CA  1 
ATOM   4010 C  C   . HIS A 1 535 ? -19.245 -41.110 -26.054 0.40 63.57  ? 798  HIS A C   1 
ATOM   4011 O  O   . HIS A 1 535 ? -19.536 -41.626 -27.153 0.40 62.20  ? 798  HIS A O   1 
ATOM   4012 C  CB  . HIS A 1 535 ? -16.780 -40.381 -26.163 0.40 59.58  ? 798  HIS A CB  1 
ATOM   4013 C  CG  . HIS A 1 535 ? -16.299 -41.247 -25.045 0.40 56.20  ? 798  HIS A CG  1 
ATOM   4014 N  ND1 . HIS A 1 535 ? -16.701 -42.566 -24.898 0.40 53.37  ? 798  HIS A ND1 1 
ATOM   4015 C  CD2 . HIS A 1 535 ? -15.440 -41.001 -24.032 0.40 53.94  ? 798  HIS A CD2 1 
ATOM   4016 C  CE1 . HIS A 1 535 ? -16.122 -43.087 -23.836 0.40 52.23  ? 798  HIS A CE1 1 
ATOM   4017 N  NE2 . HIS A 1 535 ? -15.341 -42.148 -23.287 0.40 54.14  ? 798  HIS A NE2 1 
ATOM   4018 N  N   . ALA A 1 536 ? -19.771 -41.475 -24.874 0.40 62.88  ? 799  ALA A N   1 
ATOM   4019 C  CA  . ALA A 1 536 ? -20.611 -42.674 -24.615 0.40 61.07  ? 799  ALA A CA  1 
ATOM   4020 C  C   . ALA A 1 536 ? -22.004 -42.516 -25.250 0.40 58.01  ? 799  ALA A C   1 
ATOM   4021 O  O   . ALA A 1 536 ? -22.452 -41.361 -25.409 0.40 58.23  ? 799  ALA A O   1 
ATOM   4022 C  CB  . ALA A 1 536 ? -20.704 -42.904 -23.122 0.40 60.65  ? 799  ALA A CB  1 
ATOM   4023 N  N   . THR A 1 537 ? -22.666 -43.636 -25.584 0.40 53.49  ? 800  THR A N   1 
ATOM   4024 C  CA  . THR A 1 537 ? -24.005 -43.674 -26.238 0.40 50.69  ? 800  THR A CA  1 
ATOM   4025 C  C   . THR A 1 537 ? -24.941 -44.656 -25.514 0.40 48.66  ? 800  THR A C   1 
ATOM   4026 O  O   . THR A 1 537 ? -26.127 -44.692 -25.865 0.40 44.04  ? 800  THR A O   1 
ATOM   4027 C  CB  . THR A 1 537 ? -23.905 -44.038 -27.725 0.40 50.55  ? 800  THR A CB  1 
ATOM   4028 O  OG1 . THR A 1 537 ? -23.235 -45.293 -27.830 0.40 51.74  ? 800  THR A OG1 1 
ATOM   4029 C  CG2 . THR A 1 537 ? -23.188 -42.994 -28.551 0.40 50.03  ? 800  THR A CG2 1 
ATOM   4030 N  N   . HIS A 1 538 ? -24.428 -45.441 -24.564 0.40 50.06  ? 801  HIS A N   1 
ATOM   4031 C  CA  . HIS A 1 538 ? -25.237 -46.241 -23.603 0.40 48.25  ? 801  HIS A CA  1 
ATOM   4032 C  C   . HIS A 1 538 ? -26.278 -47.125 -24.308 0.40 43.57  ? 801  HIS A C   1 
ATOM   4033 O  O   . HIS A 1 538 ? -27.440 -47.119 -23.853 0.40 40.37  ? 801  HIS A O   1 
ATOM   4034 C  CB  . HIS A 1 538 ? -25.958 -45.304 -22.627 0.40 49.57  ? 801  HIS A CB  1 
ATOM   4035 C  CG  . HIS A 1 538 ? -25.044 -44.558 -21.721 0.40 52.68  ? 801  HIS A CG  1 
ATOM   4036 N  ND1 . HIS A 1 538 ? -24.801 -44.966 -20.425 0.40 55.21  ? 801  HIS A ND1 1 
ATOM   4037 C  CD2 . HIS A 1 538 ? -24.324 -43.431 -21.912 0.40 55.81  ? 801  HIS A CD2 1 
ATOM   4038 C  CE1 . HIS A 1 538 ? -23.962 -44.124 -19.853 0.40 57.40  ? 801  HIS A CE1 1 
ATOM   4039 N  NE2 . HIS A 1 538 ? -23.653 -43.172 -20.748 0.40 56.64  ? 801  HIS A NE2 1 
ATOM   4040 N  N   . GLU A 1 539 ? -25.887 -47.894 -25.328 0.40 41.11  ? 802  GLU A N   1 
ATOM   4041 C  CA  . GLU A 1 539 ? -26.797 -48.836 -26.036 0.40 43.58  ? 802  GLU A CA  1 
ATOM   4042 C  C   . GLU A 1 539 ? -27.160 -50.021 -25.127 0.40 42.57  ? 802  GLU A C   1 
ATOM   4043 O  O   . GLU A 1 539 ? -28.065 -50.799 -25.504 0.40 41.53  ? 802  GLU A O   1 
ATOM   4044 C  CB  . GLU A 1 539 ? -26.166 -49.349 -27.328 0.40 47.01  ? 802  GLU A CB  1 
ATOM   4045 C  CG  . GLU A 1 539 ? -26.495 -48.499 -28.541 0.40 50.42  ? 802  GLU A CG  1 
ATOM   4046 C  CD  . GLU A 1 539 ? -25.487 -47.400 -28.797 0.40 55.01  ? 802  GLU A CD  1 
ATOM   4047 O  OE1 . GLU A 1 539 ? -25.483 -46.860 -29.928 0.40 57.34  ? 802  GLU A OE1 1 
ATOM   4048 O  OE2 . GLU A 1 539 ? -24.707 -47.098 -27.863 0.40 62.17  ? 802  GLU A OE2 1 
ATOM   4049 N  N   . TRP A 1 540 ? -26.491 -50.152 -23.979 0.50 39.93  ? 803  TRP A N   1 
ATOM   4050 C  CA  . TRP A 1 540 ? -26.702 -51.258 -23.007 0.50 39.84  ? 803  TRP A CA  1 
ATOM   4051 C  C   . TRP A 1 540 ? -27.835 -50.905 -22.039 0.50 39.84  ? 803  TRP A C   1 
ATOM   4052 O  O   . TRP A 1 540 ? -28.242 -51.786 -21.265 0.50 36.58  ? 803  TRP A O   1 
ATOM   4053 C  CB  . TRP A 1 540 ? -25.403 -51.574 -22.258 0.50 37.73  ? 803  TRP A CB  1 
ATOM   4054 C  CG  . TRP A 1 540 ? -24.817 -50.424 -21.502 0.50 35.36  ? 803  TRP A CG  1 
ATOM   4055 C  CD1 . TRP A 1 540 ? -25.120 -50.038 -20.230 0.50 35.58  ? 803  TRP A CD1 1 
ATOM   4056 C  CD2 . TRP A 1 540 ? -23.789 -49.525 -21.959 0.50 34.59  ? 803  TRP A CD2 1 
ATOM   4057 N  NE1 . TRP A 1 540 ? -24.360 -48.956 -19.867 0.50 36.15  ? 803  TRP A NE1 1 
ATOM   4058 C  CE2 . TRP A 1 540 ? -23.537 -48.617 -20.909 0.50 34.20  ? 803  TRP A CE2 1 
ATOM   4059 C  CE3 . TRP A 1 540 ? -23.075 -49.386 -23.155 0.50 35.29  ? 803  TRP A CE3 1 
ATOM   4060 C  CZ2 . TRP A 1 540 ? -22.596 -47.592 -21.017 0.50 34.75  ? 803  TRP A CZ2 1 
ATOM   4061 C  CZ3 . TRP A 1 540 ? -22.138 -48.379 -23.259 0.50 36.44  ? 803  TRP A CZ3 1 
ATOM   4062 C  CH2 . TRP A 1 540 ? -21.897 -47.500 -22.201 0.50 36.06  ? 803  TRP A CH2 1 
ATOM   4063 N  N   . MET A 1 541 ? -28.303 -49.654 -22.066 0.50 42.19  ? 804  MET A N   1 
ATOM   4064 C  CA  . MET A 1 541 ? -29.427 -49.177 -21.215 0.50 43.64  ? 804  MET A CA  1 
ATOM   4065 C  C   . MET A 1 541 ? -30.740 -49.510 -21.930 0.50 43.88  ? 804  MET A C   1 
ATOM   4066 O  O   . MET A 1 541 ? -31.280 -48.607 -22.589 0.50 47.12  ? 804  MET A O   1 
ATOM   4067 C  CB  . MET A 1 541 ? -29.344 -47.666 -20.973 0.50 44.12  ? 804  MET A CB  1 
ATOM   4068 C  CG  . MET A 1 541 ? -28.142 -47.251 -20.154 0.50 44.24  ? 804  MET A CG  1 
ATOM   4069 S  SD  . MET A 1 541 ? -27.944 -48.260 -18.661 0.50 46.97  ? 804  MET A SD  1 
ATOM   4070 C  CE  . MET A 1 541 ? -29.169 -47.526 -17.577 0.50 46.42  ? 804  MET A CE  1 
ATOM   4071 N  N   . THR A 1 542 ? -31.204 -50.760 -21.817 0.50 44.26  ? 805  THR A N   1 
ATOM   4072 C  CA  . THR A 1 542 ? -32.346 -51.334 -22.580 0.50 46.12  ? 805  THR A CA  1 
ATOM   4073 C  C   . THR A 1 542 ? -32.753 -52.679 -21.972 0.50 45.60  ? 805  THR A C   1 
ATOM   4074 O  O   . THR A 1 542 ? -31.953 -53.252 -21.200 0.50 46.30  ? 805  THR A O   1 
ATOM   4075 C  CB  . THR A 1 542 ? -31.995 -51.532 -24.063 0.50 48.74  ? 805  THR A CB  1 
ATOM   4076 O  OG1 . THR A 1 542 ? -33.081 -52.161 -24.744 0.50 47.00  ? 805  THR A OG1 1 
ATOM   4077 C  CG2 . THR A 1 542 ? -30.772 -52.398 -24.267 0.50 49.04  ? 805  THR A CG2 1 
ATOM   4078 N  N   . THR A 1 543 ? -33.953 -53.154 -22.314 1.00 45.89  ? 806  THR A N   1 
ATOM   4079 C  CA  . THR A 1 543 ? -34.461 -54.502 -21.923 1.00 47.26  ? 806  THR A CA  1 
ATOM   4080 C  C   . THR A 1 543 ? -34.504 -55.372 -23.182 1.00 40.23  ? 806  THR A C   1 
ATOM   4081 O  O   . THR A 1 543 ? -34.786 -56.538 -23.051 1.00 41.48  ? 806  THR A O   1 
ATOM   4082 C  CB  . THR A 1 543 ? -35.785 -54.423 -21.141 1.00 56.74  ? 806  THR A CB  1 
ATOM   4083 O  OG1 . THR A 1 543 ? -36.627 -53.376 -21.631 1.00 49.16  ? 806  THR A OG1 1 
ATOM   4084 C  CG2 . THR A 1 543 ? -35.559 -54.187 -19.661 1.00 65.00  ? 806  THR A CG2 1 
ATOM   4085 N  N   . GLU A 1 544 ? -34.139 -54.848 -24.346 1.00 40.56  ? 807  GLU A N   1 
ATOM   4086 C  CA  . GLU A 1 544 ? -33.971 -55.655 -25.583 1.00 37.86  ? 807  GLU A CA  1 
ATOM   4087 C  C   . GLU A 1 544 ? -32.992 -56.785 -25.300 1.00 39.43  ? 807  GLU A C   1 
ATOM   4088 O  O   . GLU A 1 544 ? -32.197 -56.688 -24.331 1.00 36.27  ? 807  GLU A O   1 
ATOM   4089 C  CB  . GLU A 1 544 ? -33.466 -54.743 -26.692 1.00 44.88  ? 807  GLU A CB  1 
ATOM   4090 C  CG  . GLU A 1 544 ? -33.634 -55.306 -28.075 1.00 56.74  ? 807  GLU A CG  1 
ATOM   4091 C  CD  . GLU A 1 544 ? -33.631 -54.236 -29.164 1.00 63.80  ? 807  GLU A CD  1 
ATOM   4092 O  OE1 . GLU A 1 544 ? -34.329 -54.426 -30.204 1.00 62.61  ? 807  GLU A OE1 1 
ATOM   4093 O  OE2 . GLU A 1 544 ? -32.924 -53.214 -28.987 1.00 59.90  ? 807  GLU A OE2 1 
ATOM   4094 N  N   . ASP A 1 545 ? -33.075 -57.854 -26.077 1.00 41.81  ? 808  ASP A N   1 
ATOM   4095 C  CA  . ASP A 1 545 ? -32.181 -59.028 -25.976 1.00 45.32  ? 808  ASP A CA  1 
ATOM   4096 C  C   . ASP A 1 545 ? -30.760 -58.571 -26.359 1.00 43.72  ? 808  ASP A C   1 
ATOM   4097 O  O   . ASP A 1 545 ? -30.635 -57.914 -27.391 1.00 38.81  ? 808  ASP A O   1 
ATOM   4098 C  CB  . ASP A 1 545 ? -32.704 -60.148 -26.877 1.00 50.75  ? 808  ASP A CB  1 
ATOM   4099 C  CG  . ASP A 1 545 ? -31.632 -61.118 -27.306 1.00 62.33  ? 808  ASP A CG  1 
ATOM   4100 O  OD1 . ASP A 1 545 ? -31.499 -61.331 -28.520 1.00 84.08  ? 808  ASP A OD1 1 
ATOM   4101 O  OD2 . ASP A 1 545 ? -30.934 -61.650 -26.421 1.00 85.87  ? 808  ASP A OD2 1 
ATOM   4102 N  N   . MET A 1 546 ? -29.723 -58.924 -25.589 1.00 38.62  ? 809  MET A N   1 
ATOM   4103 C  CA  . MET A 1 546 ? -28.375 -58.308 -25.764 1.00 37.91  ? 809  MET A CA  1 
ATOM   4104 C  C   . MET A 1 546 ? -27.739 -58.806 -27.062 1.00 35.15  ? 809  MET A C   1 
ATOM   4105 O  O   . MET A 1 546 ? -26.927 -58.043 -27.634 1.00 36.71  ? 809  MET A O   1 
ATOM   4106 C  CB  . MET A 1 546 ? -27.461 -58.538 -24.551 1.00 43.94  ? 809  MET A CB  1 
ATOM   4107 C  CG  . MET A 1 546 ? -27.741 -57.577 -23.372 1.00 44.35  ? 809  MET A CG  1 
ATOM   4108 S  SD  . MET A 1 546 ? -27.559 -55.804 -23.824 1.00 52.97  ? 809  MET A SD  1 
ATOM   4109 C  CE  . MET A 1 546 ? -29.243 -55.382 -24.218 1.00 64.82  ? 809  MET A CE  1 
ATOM   4110 N  N   . LEU A 1 547 ? -28.073 -60.002 -27.542 1.00 31.73  ? 810  LEU A N   1 
ATOM   4111 C  CA  . LEU A 1 547 ? -27.481 -60.470 -28.827 1.00 38.09  ? 810  LEU A CA  1 
ATOM   4112 C  C   . LEU A 1 547 ? -28.058 -59.626 -29.962 1.00 42.04  ? 810  LEU A C   1 
ATOM   4113 O  O   . LEU A 1 547 ? -27.332 -59.414 -30.956 1.00 42.61  ? 810  LEU A O   1 
ATOM   4114 C  CB  . LEU A 1 547 ? -27.758 -61.950 -29.081 1.00 40.63  ? 810  LEU A CB  1 
ATOM   4115 C  CG  . LEU A 1 547 ? -27.181 -62.505 -30.383 1.00 41.05  ? 810  LEU A CG  1 
ATOM   4116 C  CD1 . LEU A 1 547 ? -25.664 -62.442 -30.383 1.00 41.31  ? 810  LEU A CD1 1 
ATOM   4117 C  CD2 . LEU A 1 547 ? -27.621 -63.940 -30.578 1.00 42.81  ? 810  LEU A CD2 1 
ATOM   4118 N  N   . THR A 1 548 ? -29.302 -59.157 -29.828 1.00 38.77  ? 811  THR A N   1 
ATOM   4119 C  CA  . THR A 1 548 ? -29.939 -58.291 -30.857 1.00 41.10  ? 811  THR A CA  1 
ATOM   4120 C  C   . THR A 1 548 ? -29.227 -56.940 -30.878 1.00 36.10  ? 811  THR A C   1 
ATOM   4121 O  O   . THR A 1 548 ? -28.907 -56.471 -31.975 1.00 37.89  ? 811  THR A O   1 
ATOM   4122 C  CB  . THR A 1 548 ? -31.449 -58.155 -30.634 1.00 40.82  ? 811  THR A CB  1 
ATOM   4123 O  OG1 . THR A 1 548 ? -31.918 -59.488 -30.800 1.00 39.23  ? 811  THR A OG1 1 
ATOM   4124 C  CG2 . THR A 1 548 ? -32.132 -57.203 -31.591 1.00 40.38  ? 811  THR A CG2 1 
ATOM   4125 N  N   . VAL A 1 549 ? -28.973 -56.366 -29.714 1.00 30.92  ? 812  VAL A N   1 
ATOM   4126 C  CA  . VAL A 1 549 ? -28.215 -55.091 -29.605 1.00 40.41  ? 812  VAL A CA  1 
ATOM   4127 C  C   . VAL A 1 549 ? -26.799 -55.303 -30.166 1.00 37.27  ? 812  VAL A C   1 
ATOM   4128 O  O   . VAL A 1 549 ? -26.314 -54.421 -30.910 1.00 34.78  ? 812  VAL A O   1 
ATOM   4129 C  CB  . VAL A 1 549 ? -28.147 -54.561 -28.158 1.00 44.46  ? 812  VAL A CB  1 
ATOM   4130 C  CG1 . VAL A 1 549 ? -27.419 -53.217 -28.105 1.00 36.63  ? 812  VAL A CG1 1 
ATOM   4131 C  CG2 . VAL A 1 549 ? -29.542 -54.457 -27.562 1.00 47.63  ? 812  VAL A CG2 1 
ATOM   4132 N  N   . TRP A 1 550 ? -26.146 -56.416 -29.821 1.00 35.81  ? 813  TRP A N   1 
ATOM   4133 C  CA  . TRP A 1 550 ? -24.750 -56.652 -30.265 1.00 35.19  ? 813  TRP A CA  1 
ATOM   4134 C  C   . TRP A 1 550 ? -24.763 -56.570 -31.784 1.00 37.76  ? 813  TRP A C   1 
ATOM   4135 O  O   . TRP A 1 550 ? -23.963 -55.805 -32.344 1.00 35.78  ? 813  TRP A O   1 
ATOM   4136 C  CB  . TRP A 1 550 ? -24.184 -57.968 -29.722 1.00 34.23  ? 813  TRP A CB  1 
ATOM   4137 C  CG  . TRP A 1 550 ? -22.716 -58.129 -29.944 1.00 34.46  ? 813  TRP A CG  1 
ATOM   4138 C  CD1 . TRP A 1 550 ? -21.725 -57.958 -29.011 1.00 37.90  ? 813  TRP A CD1 1 
ATOM   4139 C  CD2 . TRP A 1 550 ? -22.057 -58.501 -31.165 1.00 34.32  ? 813  TRP A CD2 1 
ATOM   4140 N  NE1 . TRP A 1 550 ? -20.498 -58.199 -29.577 1.00 38.26  ? 813  TRP A NE1 1 
ATOM   4141 C  CE2 . TRP A 1 550 ? -20.671 -58.493 -30.904 1.00 34.57  ? 813  TRP A CE2 1 
ATOM   4142 C  CE3 . TRP A 1 550 ? -22.492 -58.858 -32.438 1.00 36.02  ? 813  TRP A CE3 1 
ATOM   4143 C  CZ2 . TRP A 1 550 ? -19.732 -58.833 -31.862 1.00 32.89  ? 813  TRP A CZ2 1 
ATOM   4144 C  CZ3 . TRP A 1 550 ? -21.555 -59.152 -33.401 1.00 33.15  ? 813  TRP A CZ3 1 
ATOM   4145 C  CH2 . TRP A 1 550 ? -20.196 -59.148 -33.113 1.00 35.08  ? 813  TRP A CH2 1 
ATOM   4146 N  N   . ASN A 1 551 ? -25.688 -57.286 -32.425 1.00 37.87  ? 814  ASN A N   1 
ATOM   4147 C  CA  . ASN A 1 551 ? -25.787 -57.347 -33.910 1.00 39.54  ? 814  ASN A CA  1 
ATOM   4148 C  C   . ASN A 1 551 ? -26.012 -55.939 -34.473 1.00 39.02  ? 814  ASN A C   1 
ATOM   4149 O  O   . ASN A 1 551 ? -25.436 -55.608 -35.520 1.00 41.74  ? 814  ASN A O   1 
ATOM   4150 C  CB  . ASN A 1 551 ? -26.872 -58.328 -34.366 1.00 41.71  ? 814  ASN A CB  1 
ATOM   4151 C  CG  . ASN A 1 551 ? -26.376 -59.755 -34.534 1.00 44.08  ? 814  ASN A CG  1 
ATOM   4152 O  OD1 . ASN A 1 551 ? -25.505 -60.034 -35.354 1.00 42.92  ? 814  ASN A OD1 1 
ATOM   4153 N  ND2 . ASN A 1 551 ? -26.949 -60.689 -33.788 1.00 47.48  ? 814  ASN A ND2 1 
ATOM   4154 N  N   . ARG A 1 552 ? -26.880 -55.146 -33.851 1.00 40.34  ? 815  ARG A N   1 
ATOM   4155 C  CA  . ARG A 1 552 ? -27.183 -53.793 -34.382 1.00 39.56  ? 815  ARG A CA  1 
ATOM   4156 C  C   . ARG A 1 552 ? -25.895 -52.947 -34.322 1.00 41.49  ? 815  ARG A C   1 
ATOM   4157 O  O   . ARG A 1 552 ? -25.561 -52.246 -35.334 1.00 36.29  ? 815  ARG A O   1 
ATOM   4158 C  CB  . ARG A 1 552 ? -28.360 -53.207 -33.583 1.00 39.89  ? 815  ARG A CB  1 
ATOM   4159 C  CG  . ARG A 1 552 ? -28.791 -51.802 -33.997 1.00 43.89  ? 815  ARG A CG  1 
ATOM   4160 C  CD  . ARG A 1 552 ? -29.755 -51.171 -33.003 1.00 46.83  ? 815  ARG A CD  1 
ATOM   4161 N  NE  . ARG A 1 552 ? -30.867 -52.092 -32.889 1.00 59.33  ? 815  ARG A NE  1 
ATOM   4162 C  CZ  . ARG A 1 552 ? -31.452 -52.521 -31.760 1.00 62.96  ? 815  ARG A CZ  1 
ATOM   4163 N  NH1 . ARG A 1 552 ? -31.100 -52.057 -30.566 1.00 58.62  ? 815  ARG A NH1 1 
ATOM   4164 N  NH2 . ARG A 1 552 ? -32.432 -53.404 -31.865 1.00 63.97  ? 815  ARG A NH2 1 
ATOM   4165 N  N   . VAL A 1 553 ? -25.214 -52.981 -33.158 1.00 38.47  ? 816  VAL A N   1 
ATOM   4166 C  CA  . VAL A 1 553 ? -24.088 -52.068 -32.804 1.00 35.21  ? 816  VAL A CA  1 
ATOM   4167 C  C   . VAL A 1 553 ? -22.837 -52.483 -33.587 1.00 36.90  ? 816  VAL A C   1 
ATOM   4168 O  O   . VAL A 1 553 ? -22.203 -51.591 -34.170 1.00 40.54  ? 816  VAL A O   1 
ATOM   4169 C  CB  . VAL A 1 553 ? -23.840 -52.026 -31.288 1.00 37.78  ? 816  VAL A CB  1 
ATOM   4170 C  CG1 . VAL A 1 553 ? -22.488 -51.435 -30.997 1.00 38.21  ? 816  VAL A CG1 1 
ATOM   4171 C  CG2 . VAL A 1 553 ? -24.920 -51.240 -30.560 1.00 36.75  ? 816  VAL A CG2 1 
ATOM   4172 N  N   . TRP A 1 554 ? -22.503 -53.776 -33.609 1.00 35.31  ? 817  TRP A N   1 
ATOM   4173 C  CA  . TRP A 1 554 ? -21.224 -54.279 -34.167 1.00 33.82  ? 817  TRP A CA  1 
ATOM   4174 C  C   . TRP A 1 554 ? -21.346 -54.626 -35.664 1.00 37.10  ? 817  TRP A C   1 
ATOM   4175 O  O   . TRP A 1 554 ? -20.297 -54.643 -36.342 1.00 36.57  ? 817  TRP A O   1 
ATOM   4176 C  CB  . TRP A 1 554 ? -20.681 -55.417 -33.295 1.00 31.43  ? 817  TRP A CB  1 
ATOM   4177 C  CG  . TRP A 1 554 ? -20.175 -54.936 -31.970 1.00 30.70  ? 817  TRP A CG  1 
ATOM   4178 C  CD1 . TRP A 1 554 ? -20.765 -55.054 -30.740 1.00 30.43  ? 817  TRP A CD1 1 
ATOM   4179 C  CD2 . TRP A 1 554 ? -18.938 -54.222 -31.744 1.00 26.63  ? 817  TRP A CD2 1 
ATOM   4180 N  NE1 . TRP A 1 554 ? -19.963 -54.489 -29.765 1.00 29.26  ? 817  TRP A NE1 1 
ATOM   4181 C  CE2 . TRP A 1 554 ? -18.854 -53.944 -30.361 1.00 26.68  ? 817  TRP A CE2 1 
ATOM   4182 C  CE3 . TRP A 1 554 ? -17.894 -53.819 -32.560 1.00 27.90  ? 817  TRP A CE3 1 
ATOM   4183 C  CZ2 . TRP A 1 554 ? -17.784 -53.244 -29.807 1.00 29.01  ? 817  TRP A CZ2 1 
ATOM   4184 C  CZ3 . TRP A 1 554 ? -16.808 -53.148 -32.007 1.00 27.27  ? 817  TRP A CZ3 1 
ATOM   4185 C  CH2 . TRP A 1 554 ? -16.752 -52.869 -30.648 1.00 25.80  ? 817  TRP A CH2 1 
ATOM   4186 N  N   . ILE A 1 555 ? -22.555 -54.854 -36.195 1.00 39.38  ? 818  ILE A N   1 
ATOM   4187 C  CA  . ILE A 1 555 ? -22.727 -55.338 -37.602 1.00 42.37  ? 818  ILE A CA  1 
ATOM   4188 C  C   . ILE A 1 555 ? -23.555 -54.325 -38.394 1.00 40.10  ? 818  ILE A C   1 
ATOM   4189 O  O   . ILE A 1 555 ? -23.000 -53.627 -39.238 1.00 37.75  ? 818  ILE A O   1 
ATOM   4190 C  CB  . ILE A 1 555 ? -23.368 -56.737 -37.670 1.00 46.79  ? 818  ILE A CB  1 
ATOM   4191 C  CG1 . ILE A 1 555 ? -22.723 -57.764 -36.731 1.00 46.51  ? 818  ILE A CG1 1 
ATOM   4192 C  CG2 . ILE A 1 555 ? -23.349 -57.220 -39.112 1.00 51.10  ? 818  ILE A CG2 1 
ATOM   4193 C  CD1 . ILE A 1 555 ? -21.303 -58.102 -37.066 1.00 49.22  ? 818  ILE A CD1 1 
ATOM   4194 N  N   . GLN A 1 556 ? -24.834 -54.213 -38.071 1.00 46.35  ? 819  GLN A N   1 
ATOM   4195 C  CA  . GLN A 1 556 ? -25.825 -53.428 -38.854 1.00 49.37  ? 819  GLN A CA  1 
ATOM   4196 C  C   . GLN A 1 556 ? -25.408 -51.959 -38.910 1.00 42.60  ? 819  GLN A C   1 
ATOM   4197 O  O   . GLN A 1 556 ? -25.321 -51.443 -40.015 1.00 47.57  ? 819  GLN A O   1 
ATOM   4198 C  CB  . GLN A 1 556 ? -27.216 -53.624 -38.259 1.00 54.83  ? 819  GLN A CB  1 
ATOM   4199 C  CG  . GLN A 1 556 ? -28.348 -53.046 -39.103 1.00 64.38  ? 819  GLN A CG  1 
ATOM   4200 C  CD  . GLN A 1 556 ? -29.543 -52.674 -38.251 1.00 65.50  ? 819  GLN A CD  1 
ATOM   4201 O  OE1 . GLN A 1 556 ? -29.981 -51.526 -38.241 1.00 71.83  ? 819  GLN A OE1 1 
ATOM   4202 N  NE2 . GLN A 1 556 ? -30.049 -53.634 -37.484 1.00 64.14  ? 819  GLN A NE2 1 
ATOM   4203 N  N   . GLU A 1 557 ? -25.116 -51.321 -37.779 1.00 40.07  ? 820  GLU A N   1 
ATOM   4204 C  CA  . GLU A 1 557 ? -24.948 -49.845 -37.700 1.00 44.31  ? 820  GLU A CA  1 
ATOM   4205 C  C   . GLU A 1 557 ? -23.460 -49.460 -37.809 1.00 45.37  ? 820  GLU A C   1 
ATOM   4206 O  O   . GLU A 1 557 ? -23.147 -48.248 -37.759 1.00 43.01  ? 820  GLU A O   1 
ATOM   4207 C  CB  . GLU A 1 557 ? -25.631 -49.330 -36.429 1.00 48.49  ? 820  GLU A CB  1 
ATOM   4208 C  CG  . GLU A 1 557 ? -27.150 -49.440 -36.503 1.00 58.84  ? 820  GLU A CG  1 
ATOM   4209 C  CD  . GLU A 1 557 ? -27.938 -48.803 -35.360 1.00 71.06  ? 820  GLU A CD  1 
ATOM   4210 O  OE1 . GLU A 1 557 ? -27.319 -48.412 -34.326 1.00 77.87  ? 820  GLU A OE1 1 
ATOM   4211 O  OE2 . GLU A 1 557 ? -29.188 -48.710 -35.492 1.00 87.01  ? 820  GLU A OE2 1 
ATOM   4212 N  N   . ASN A 1 558 ? -22.576 -50.436 -38.045 1.00 42.07  ? 821  ASN A N   1 
ATOM   4213 C  CA  . ASN A 1 558 ? -21.103 -50.261 -37.951 1.00 40.64  ? 821  ASN A CA  1 
ATOM   4214 C  C   . ASN A 1 558 ? -20.582 -49.929 -39.344 1.00 38.51  ? 821  ASN A C   1 
ATOM   4215 O  O   . ASN A 1 558 ? -20.425 -50.828 -40.145 1.00 38.29  ? 821  ASN A O   1 
ATOM   4216 C  CB  . ASN A 1 558 ? -20.471 -51.526 -37.326 1.00 39.41  ? 821  ASN A CB  1 
ATOM   4217 C  CG  . ASN A 1 558 ? -18.951 -51.575 -37.342 1.00 37.33  ? 821  ASN A CG  1 
ATOM   4218 O  OD1 . ASN A 1 558 ? -18.284 -50.645 -37.800 1.00 35.49  ? 821  ASN A OD1 1 
ATOM   4219 N  ND2 . ASN A 1 558 ? -18.396 -52.670 -36.837 1.00 35.74  ? 821  ASN A ND2 1 
ATOM   4220 N  N   . PRO A 1 559 ? -20.232 -48.663 -39.668 1.00 41.25  ? 822  PRO A N   1 
ATOM   4221 C  CA  . PRO A 1 559 ? -19.782 -48.323 -41.019 1.00 41.03  ? 822  PRO A CA  1 
ATOM   4222 C  C   . PRO A 1 559 ? -18.460 -48.986 -41.440 1.00 43.35  ? 822  PRO A C   1 
ATOM   4223 O  O   . PRO A 1 559 ? -18.146 -48.901 -42.594 1.00 46.49  ? 822  PRO A O   1 
ATOM   4224 C  CB  . PRO A 1 559 ? -19.619 -46.784 -40.989 1.00 41.07  ? 822  PRO A CB  1 
ATOM   4225 C  CG  . PRO A 1 559 ? -19.443 -46.471 -39.500 1.00 41.62  ? 822  PRO A CG  1 
ATOM   4226 C  CD  . PRO A 1 559 ? -20.310 -47.481 -38.793 1.00 39.15  ? 822  PRO A CD  1 
ATOM   4227 N  N   . TRP A 1 560 ? -17.694 -49.587 -40.521 1.00 43.95  ? 823  TRP A N   1 
ATOM   4228 C  CA  . TRP A 1 560 ? -16.424 -50.286 -40.871 1.00 40.95  ? 823  TRP A CA  1 
ATOM   4229 C  C   . TRP A 1 560 ? -16.658 -51.775 -41.183 1.00 41.71  ? 823  TRP A C   1 
ATOM   4230 O  O   . TRP A 1 560 ? -15.720 -52.408 -41.564 1.00 44.84  ? 823  TRP A O   1 
ATOM   4231 C  CB  . TRP A 1 560 ? -15.391 -50.072 -39.762 1.00 42.85  ? 823  TRP A CB  1 
ATOM   4232 C  CG  . TRP A 1 560 ? -14.943 -48.646 -39.643 1.00 37.09  ? 823  TRP A CG  1 
ATOM   4233 C  CD1 . TRP A 1 560 ? -13.993 -48.005 -40.387 1.00 31.34  ? 823  TRP A CD1 1 
ATOM   4234 C  CD2 . TRP A 1 560 ? -15.474 -47.663 -38.733 1.00 33.76  ? 823  TRP A CD2 1 
ATOM   4235 N  NE1 . TRP A 1 560 ? -13.890 -46.693 -39.989 1.00 36.07  ? 823  TRP A NE1 1 
ATOM   4236 C  CE2 . TRP A 1 560 ? -14.799 -46.451 -38.983 1.00 33.26  ? 823  TRP A CE2 1 
ATOM   4237 C  CE3 . TRP A 1 560 ? -16.403 -47.705 -37.698 1.00 34.24  ? 823  TRP A CE3 1 
ATOM   4238 C  CZ2 . TRP A 1 560 ? -15.020 -45.308 -38.214 1.00 34.18  ? 823  TRP A CZ2 1 
ATOM   4239 C  CZ3 . TRP A 1 560 ? -16.648 -46.563 -36.969 1.00 35.65  ? 823  TRP A CZ3 1 
ATOM   4240 C  CH2 . TRP A 1 560 ? -15.955 -45.377 -37.214 1.00 33.22  ? 823  TRP A CH2 1 
ATOM   4241 N  N   . MET A 1 561 ? -17.886 -52.301 -41.069 1.00 49.81  ? 824  MET A N   1 
ATOM   4242 C  CA  . MET A 1 561 ? -18.254 -53.703 -41.438 1.00 45.75  ? 824  MET A CA  1 
ATOM   4243 C  C   . MET A 1 561 ? -19.066 -53.680 -42.755 1.00 45.80  ? 824  MET A C   1 
ATOM   4244 O  O   . MET A 1 561 ? -20.161 -53.113 -42.765 1.00 42.76  ? 824  MET A O   1 
ATOM   4245 C  CB  . MET A 1 561 ? -19.062 -54.313 -40.294 1.00 46.86  ? 824  MET A CB  1 
ATOM   4246 C  CG  . MET A 1 561 ? -19.224 -55.811 -40.344 1.00 53.48  ? 824  MET A CG  1 
ATOM   4247 S  SD  . MET A 1 561 ? -17.745 -56.622 -39.739 1.00 67.87  ? 824  MET A SD  1 
ATOM   4248 C  CE  . MET A 1 561 ? -17.924 -56.399 -37.968 1.00 66.12  ? 824  MET A CE  1 
ATOM   4249 N  N   . GLU A 1 562 ? -18.518 -54.203 -43.856 1.00 49.99  ? 825  GLU A N   1 
ATOM   4250 C  CA  . GLU A 1 562 ? -19.165 -54.210 -45.208 1.00 54.30  ? 825  GLU A CA  1 
ATOM   4251 C  C   . GLU A 1 562 ? -20.244 -55.307 -45.287 1.00 50.13  ? 825  GLU A C   1 
ATOM   4252 O  O   . GLU A 1 562 ? -21.360 -55.023 -45.745 1.00 50.74  ? 825  GLU A O   1 
ATOM   4253 C  CB  . GLU A 1 562 ? -18.108 -54.411 -46.294 1.00 62.10  ? 825  GLU A CB  1 
ATOM   4254 C  CG  . GLU A 1 562 ? -18.550 -54.038 -47.694 1.00 68.58  ? 825  GLU A CG  1 
ATOM   4255 C  CD  . GLU A 1 562 ? -17.448 -54.144 -48.752 1.00 89.71  ? 825  GLU A CD  1 
ATOM   4256 O  OE1 . GLU A 1 562 ? -17.795 -54.391 -49.934 1.00 103.62 ? 825  GLU A OE1 1 
ATOM   4257 O  OE2 . GLU A 1 562 ? -16.239 -53.980 -48.410 1.00 76.04  ? 825  GLU A OE2 1 
ATOM   4258 N  N   . ASP A 1 563 ? -19.903 -56.522 -44.848 0.48 47.50  ? 826  ASP A N   1 
ATOM   4259 C  CA  . ASP A 1 563 ? -20.809 -57.700 -44.844 0.48 47.82  ? 826  ASP A CA  1 
ATOM   4260 C  C   . ASP A 1 563 ? -21.685 -57.646 -43.588 0.48 47.09  ? 826  ASP A C   1 
ATOM   4261 O  O   . ASP A 1 563 ? -21.128 -57.691 -42.470 0.48 47.86  ? 826  ASP A O   1 
ATOM   4262 C  CB  . ASP A 1 563 ? -20.013 -59.003 -44.920 0.48 48.63  ? 826  ASP A CB  1 
ATOM   4263 C  CG  . ASP A 1 563 ? -20.784 -60.201 -44.402 0.48 48.15  ? 826  ASP A CG  1 
ATOM   4264 O  OD1 . ASP A 1 563 ? -22.004 -60.052 -44.177 0.48 48.35  ? 826  ASP A OD1 1 
ATOM   4265 O  OD2 . ASP A 1 563 ? -20.151 -61.260 -44.201 0.48 51.37  ? 826  ASP A OD2 1 
ATOM   4266 N  N   . LYS A 1 564 ? -23.005 -57.569 -43.773 0.48 45.26  ? 827  LYS A N   1 
ATOM   4267 C  CA  . LYS A 1 564 ? -23.979 -57.273 -42.692 0.48 44.33  ? 827  LYS A CA  1 
ATOM   4268 C  C   . LYS A 1 564 ? -24.680 -58.557 -42.244 0.48 43.32  ? 827  LYS A C   1 
ATOM   4269 O  O   . LYS A 1 564 ? -25.779 -58.446 -41.668 0.48 42.76  ? 827  LYS A O   1 
ATOM   4270 C  CB  . LYS A 1 564 ? -24.993 -56.228 -43.162 0.48 45.32  ? 827  LYS A CB  1 
ATOM   4271 C  CG  . LYS A 1 564 ? -24.386 -54.899 -43.592 0.48 46.21  ? 827  LYS A CG  1 
ATOM   4272 C  CD  . LYS A 1 564 ? -23.691 -54.157 -42.477 0.48 45.91  ? 827  LYS A CD  1 
ATOM   4273 C  CE  . LYS A 1 564 ? -23.291 -52.751 -42.873 0.48 48.82  ? 827  LYS A CE  1 
ATOM   4274 N  NZ  . LYS A 1 564 ? -22.528 -52.065 -41.802 0.48 49.76  ? 827  LYS A NZ  1 
ATOM   4275 N  N   . THR A 1 565 ? -24.051 -59.717 -42.458 0.48 43.53  ? 828  THR A N   1 
ATOM   4276 C  CA  . THR A 1 565 ? -24.587 -61.045 -42.055 0.48 45.55  ? 828  THR A CA  1 
ATOM   4277 C  C   . THR A 1 565 ? -24.739 -61.094 -40.537 0.48 46.75  ? 828  THR A C   1 
ATOM   4278 O  O   . THR A 1 565 ? -23.755 -61.062 -39.799 0.48 47.27  ? 828  THR A O   1 
ATOM   4279 C  CB  . THR A 1 565 ? -23.689 -62.190 -42.539 0.48 47.64  ? 828  THR A CB  1 
ATOM   4280 O  OG1 . THR A 1 565 ? -23.634 -62.173 -43.965 0.48 51.73  ? 828  THR A OG1 1 
ATOM   4281 C  CG2 . THR A 1 565 ? -24.179 -63.544 -42.077 0.48 47.86  ? 828  THR A CG2 1 
ATOM   4282 N  N   . PRO A 1 566 ? -25.979 -61.185 -40.014 0.48 49.01  ? 829  PRO A N   1 
ATOM   4283 C  CA  . PRO A 1 566 ? -26.192 -61.285 -38.572 0.48 49.04  ? 829  PRO A CA  1 
ATOM   4284 C  C   . PRO A 1 566 ? -25.437 -62.469 -37.948 0.48 48.71  ? 829  PRO A C   1 
ATOM   4285 O  O   . PRO A 1 566 ? -25.314 -63.499 -38.575 0.48 51.64  ? 829  PRO A O   1 
ATOM   4286 C  CB  . PRO A 1 566 ? -27.708 -61.491 -38.443 0.48 49.80  ? 829  PRO A CB  1 
ATOM   4287 C  CG  . PRO A 1 566 ? -28.280 -60.912 -39.717 0.48 49.30  ? 829  PRO A CG  1 
ATOM   4288 C  CD  . PRO A 1 566 ? -27.235 -61.194 -40.775 0.48 49.18  ? 829  PRO A CD  1 
ATOM   4289 N  N   . VAL A 1 567 ? -24.936 -62.281 -36.731 0.48 47.70  ? 830  VAL A N   1 
ATOM   4290 C  CA  . VAL A 1 567 ? -24.420 -63.375 -35.862 0.48 46.80  ? 830  VAL A CA  1 
ATOM   4291 C  C   . VAL A 1 567 ? -25.629 -64.020 -35.170 0.48 48.58  ? 830  VAL A C   1 
ATOM   4292 O  O   . VAL A 1 567 ? -26.543 -63.271 -34.760 0.48 47.68  ? 830  VAL A O   1 
ATOM   4293 C  CB  . VAL A 1 567 ? -23.393 -62.823 -34.860 0.48 47.45  ? 830  VAL A CB  1 
ATOM   4294 C  CG1 . VAL A 1 567 ? -23.242 -63.734 -33.659 0.48 48.19  ? 830  VAL A CG1 1 
ATOM   4295 C  CG2 . VAL A 1 567 ? -22.045 -62.567 -35.518 0.48 46.24  ? 830  VAL A CG2 1 
ATOM   4296 N  N   . GLU A 1 568 ? -25.650 -65.352 -35.059 0.48 48.49  ? 831  GLU A N   1 
ATOM   4297 C  CA  . GLU A 1 568 ? -26.863 -66.122 -34.661 0.48 49.76  ? 831  GLU A CA  1 
ATOM   4298 C  C   . GLU A 1 568 ? -26.726 -66.629 -33.220 0.48 49.17  ? 831  GLU A C   1 
ATOM   4299 O  O   . GLU A 1 568 ? -27.748 -67.071 -32.660 0.48 48.55  ? 831  GLU A O   1 
ATOM   4300 C  CB  . GLU A 1 568 ? -27.103 -67.288 -35.627 0.48 52.21  ? 831  GLU A CB  1 
ATOM   4301 C  CG  . GLU A 1 568 ? -27.532 -66.848 -37.024 0.48 52.86  ? 831  GLU A CG  1 
ATOM   4302 C  CD  . GLU A 1 568 ? -28.808 -66.018 -37.059 0.48 53.54  ? 831  GLU A CD  1 
ATOM   4303 O  OE1 . GLU A 1 568 ? -29.563 -66.063 -36.067 0.48 52.51  ? 831  GLU A OE1 1 
ATOM   4304 O  OE2 . GLU A 1 568 ? -29.051 -65.332 -38.079 0.48 53.81  ? 831  GLU A OE2 1 
ATOM   4305 N  N   . SER A 1 569 ? -25.523 -66.569 -32.640 0.48 45.94  ? 832  SER A N   1 
ATOM   4306 C  CA  . SER A 1 569 ? -25.235 -67.075 -31.272 0.48 44.60  ? 832  SER A CA  1 
ATOM   4307 C  C   . SER A 1 569 ? -24.047 -66.327 -30.657 0.48 43.52  ? 832  SER A C   1 
ATOM   4308 O  O   . SER A 1 569 ? -23.178 -65.852 -31.415 0.48 41.48  ? 832  SER A O   1 
ATOM   4309 C  CB  . SER A 1 569 ? -24.971 -68.553 -31.301 0.48 44.06  ? 832  SER A CB  1 
ATOM   4310 O  OG  . SER A 1 569 ? -23.800 -68.832 -32.060 0.48 43.50  ? 832  SER A OG  1 
ATOM   4311 N  N   . TRP A 1 570 ? -23.999 -66.263 -29.324 1.00 41.11  ? 833  TRP A N   1 
ATOM   4312 C  CA  . TRP A 1 570 ? -22.830 -65.722 -28.598 1.00 46.05  ? 833  TRP A CA  1 
ATOM   4313 C  C   . TRP A 1 570 ? -21.553 -66.547 -28.909 1.00 45.22  ? 833  TRP A C   1 
ATOM   4314 O  O   . TRP A 1 570 ? -20.464 -65.958 -28.965 1.00 42.74  ? 833  TRP A O   1 
ATOM   4315 C  CB  . TRP A 1 570 ? -23.179 -65.653 -27.114 1.00 41.68  ? 833  TRP A CB  1 
ATOM   4316 C  CG  . TRP A 1 570 ? -24.039 -64.479 -26.782 1.00 42.58  ? 833  TRP A CG  1 
ATOM   4317 C  CD1 . TRP A 1 570 ? -25.369 -64.485 -26.471 1.00 39.39  ? 833  TRP A CD1 1 
ATOM   4318 C  CD2 . TRP A 1 570 ? -23.613 -63.102 -26.732 1.00 40.87  ? 833  TRP A CD2 1 
ATOM   4319 N  NE1 . TRP A 1 570 ? -25.793 -63.212 -26.215 1.00 40.85  ? 833  TRP A NE1 1 
ATOM   4320 C  CE2 . TRP A 1 570 ? -24.735 -62.345 -26.345 1.00 38.18  ? 833  TRP A CE2 1 
ATOM   4321 C  CE3 . TRP A 1 570 ? -22.384 -62.449 -26.904 1.00 38.90  ? 833  TRP A CE3 1 
ATOM   4322 C  CZ2 . TRP A 1 570 ? -24.666 -60.964 -26.163 1.00 41.12  ? 833  TRP A CZ2 1 
ATOM   4323 C  CZ3 . TRP A 1 570 ? -22.322 -61.089 -26.730 1.00 37.68  ? 833  TRP A CZ3 1 
ATOM   4324 C  CH2 . TRP A 1 570 ? -23.458 -60.351 -26.386 1.00 39.45  ? 833  TRP A CH2 1 
ATOM   4325 N  N   . GLU A 1 571 ? -21.652 -67.830 -29.237 1.00 47.20  ? 834  GLU A N   1 
ATOM   4326 C  CA  . GLU A 1 571 ? -20.440 -68.636 -29.575 1.00 56.14  ? 834  GLU A CA  1 
ATOM   4327 C  C   . GLU A 1 571 ? -19.749 -68.195 -30.880 1.00 45.45  ? 834  GLU A C   1 
ATOM   4328 O  O   . GLU A 1 571 ? -18.569 -68.484 -31.009 1.00 48.05  ? 834  GLU A O   1 
ATOM   4329 C  CB  . GLU A 1 571 ? -20.792 -70.120 -29.632 1.00 63.11  ? 834  GLU A CB  1 
ATOM   4330 C  CG  . GLU A 1 571 ? -20.966 -70.690 -28.240 1.00 82.02  ? 834  GLU A CG  1 
ATOM   4331 C  CD  . GLU A 1 571 ? -21.153 -72.195 -28.160 1.00 100.80 ? 834  GLU A CD  1 
ATOM   4332 O  OE1 . GLU A 1 571 ? -20.704 -72.917 -29.106 1.00 110.96 ? 834  GLU A OE1 1 
ATOM   4333 O  OE2 . GLU A 1 571 ? -21.740 -72.646 -27.142 1.00 95.01  ? 834  GLU A OE2 1 
ATOM   4334 N  N   . GLU A 1 572 ? -20.437 -67.586 -31.840 1.00 45.16  ? 835  GLU A N   1 
ATOM   4335 C  CA  . GLU A 1 572 ? -19.802 -66.984 -33.058 1.00 49.36  ? 835  GLU A CA  1 
ATOM   4336 C  C   . GLU A 1 572 ? -18.917 -65.764 -32.701 1.00 43.31  ? 835  GLU A C   1 
ATOM   4337 O  O   . GLU A 1 572 ? -18.180 -65.260 -33.569 1.00 42.82  ? 835  GLU A O   1 
ATOM   4338 C  CB  . GLU A 1 572 ? -20.871 -66.468 -34.018 1.00 50.22  ? 835  GLU A CB  1 
ATOM   4339 C  CG  . GLU A 1 572 ? -21.128 -67.323 -35.240 1.00 61.33  ? 835  GLU A CG  1 
ATOM   4340 C  CD  . GLU A 1 572 ? -22.148 -66.699 -36.200 1.00 70.35  ? 835  GLU A CD  1 
ATOM   4341 O  OE1 . GLU A 1 572 ? -21.719 -66.191 -37.268 1.00 74.03  ? 835  GLU A OE1 1 
ATOM   4342 O  OE2 . GLU A 1 572 ? -23.374 -66.695 -35.883 1.00 57.19  ? 835  GLU A OE2 1 
ATOM   4343 N  N   . ILE A 1 573 ? -19.090 -65.209 -31.505 1.00 39.75  ? 836  ILE A N   1 
ATOM   4344 C  CA  . ILE A 1 573 ? -18.469 -63.921 -31.097 1.00 38.89  ? 836  ILE A CA  1 
ATOM   4345 C  C   . ILE A 1 573 ? -17.199 -64.262 -30.327 1.00 36.59  ? 836  ILE A C   1 
ATOM   4346 O  O   . ILE A 1 573 ? -17.240 -64.897 -29.280 1.00 35.03  ? 836  ILE A O   1 
ATOM   4347 C  CB  . ILE A 1 573 ? -19.453 -63.078 -30.283 1.00 36.12  ? 836  ILE A CB  1 
ATOM   4348 C  CG1 . ILE A 1 573 ? -20.596 -62.553 -31.164 1.00 36.65  ? 836  ILE A CG1 1 
ATOM   4349 C  CG2 . ILE A 1 573 ? -18.703 -61.980 -29.585 1.00 37.60  ? 836  ILE A CG2 1 
ATOM   4350 C  CD1 . ILE A 1 573 ? -21.820 -62.051 -30.392 1.00 33.66  ? 836  ILE A CD1 1 
ATOM   4351 N  N   . PRO A 1 574 ? -16.032 -63.847 -30.833 1.00 33.36  ? 837  PRO A N   1 
ATOM   4352 C  CA  . PRO A 1 574 ? -14.747 -64.336 -30.330 1.00 37.47  ? 837  PRO A CA  1 
ATOM   4353 C  C   . PRO A 1 574 ? -14.246 -63.639 -29.072 1.00 32.90  ? 837  PRO A C   1 
ATOM   4354 O  O   . PRO A 1 574 ? -14.769 -62.609 -28.717 1.00 34.05  ? 837  PRO A O   1 
ATOM   4355 C  CB  . PRO A 1 574 ? -13.758 -63.916 -31.420 1.00 39.03  ? 837  PRO A CB  1 
ATOM   4356 C  CG  . PRO A 1 574 ? -14.364 -62.633 -31.969 1.00 42.88  ? 837  PRO A CG  1 
ATOM   4357 C  CD  . PRO A 1 574 ? -15.876 -62.791 -31.837 1.00 41.34  ? 837  PRO A CD  1 
ATOM   4358 N  N   . TYR A 1 575 ? -13.228 -64.223 -28.437 0.48 34.11  ? 838  TYR A N   1 
ATOM   4359 C  CA  . TYR A 1 575 ? -12.459 -63.627 -27.313 0.48 34.79  ? 838  TYR A CA  1 
ATOM   4360 C  C   . TYR A 1 575 ? -11.079 -63.174 -27.819 0.48 35.33  ? 838  TYR A C   1 
ATOM   4361 O  O   . TYR A 1 575 ? -10.624 -63.681 -28.877 0.48 34.43  ? 838  TYR A O   1 
ATOM   4362 C  CB  . TYR A 1 575 ? -12.295 -64.646 -26.186 0.48 35.00  ? 838  TYR A CB  1 
ATOM   4363 C  CG  . TYR A 1 575 ? -13.576 -65.172 -25.595 0.48 35.36  ? 838  TYR A CG  1 
ATOM   4364 C  CD1 . TYR A 1 575 ? -14.197 -64.520 -24.543 0.48 35.52  ? 838  TYR A CD1 1 
ATOM   4365 C  CD2 . TYR A 1 575 ? -14.160 -66.336 -26.069 0.48 36.27  ? 838  TYR A CD2 1 
ATOM   4366 C  CE1 . TYR A 1 575 ? -15.366 -65.006 -23.979 0.48 36.38  ? 838  TYR A CE1 1 
ATOM   4367 C  CE2 . TYR A 1 575 ? -15.332 -66.833 -25.520 0.48 35.93  ? 838  TYR A CE2 1 
ATOM   4368 C  CZ  . TYR A 1 575 ? -15.937 -66.168 -24.469 0.48 36.75  ? 838  TYR A CZ  1 
ATOM   4369 O  OH  . TYR A 1 575 ? -17.093 -66.647 -23.926 0.48 37.36  ? 838  TYR A OH  1 
ATOM   4370 N  N   . LEU A 1 576 ? -10.426 -62.263 -27.085 0.48 33.30  ? 839  LEU A N   1 
ATOM   4371 C  CA  . LEU A 1 576 ? -8.970  -61.998 -27.220 0.48 33.42  ? 839  LEU A CA  1 
ATOM   4372 C  C   . LEU A 1 576 ? -8.250  -63.343 -27.061 0.48 33.97  ? 839  LEU A C   1 
ATOM   4373 O  O   . LEU A 1 576 ? -8.843  -64.272 -26.415 0.48 35.38  ? 839  LEU A O   1 
ATOM   4374 C  CB  . LEU A 1 576 ? -8.495  -61.029 -26.131 0.48 32.78  ? 839  LEU A CB  1 
ATOM   4375 C  CG  . LEU A 1 576 ? -9.140  -59.647 -26.105 0.48 32.30  ? 839  LEU A CG  1 
ATOM   4376 C  CD1 . LEU A 1 576 ? -8.622  -58.846 -24.922 0.48 31.87  ? 839  LEU A CD1 1 
ATOM   4377 C  CD2 . LEU A 1 576 ? -8.902  -58.900 -27.409 0.48 32.32  ? 839  LEU A CD2 1 
ATOM   4378 N  N   . GLY A 1 577 ? -7.033  -63.458 -27.607 0.48 33.69  ? 840  GLY A N   1 
ATOM   4379 C  CA  . GLY A 1 577 ? -6.124  -64.565 -27.257 0.48 33.37  ? 840  GLY A CA  1 
ATOM   4380 C  C   . GLY A 1 577 ? -6.104  -64.749 -25.716 0.48 33.05  ? 840  GLY A C   1 
ATOM   4381 O  O   . GLY A 1 577 ? -6.077  -63.733 -24.954 0.48 33.79  ? 840  GLY A O   1 
ATOM   4382 N  N   . LYS A 1 578 ? -5.838  -66.033 -25.319 0.48 34.22  ? 841  LYS A N   1 
ATOM   4383 C  CA  . LYS A 1 578 ? -5.726  -66.460 -23.898 0.48 35.65  ? 841  LYS A CA  1 
ATOM   4384 C  C   . LYS A 1 578 ? -4.668  -65.599 -23.189 0.48 33.49  ? 841  LYS A C   1 
ATOM   4385 O  O   . LYS A 1 578 ? -4.947  -65.130 -22.067 0.48 33.78  ? 841  LYS A O   1 
ATOM   4386 C  CB  . LYS A 1 578 ? -5.355  -67.943 -23.820 0.48 38.37  ? 841  LYS A CB  1 
ATOM   4387 C  CG  . LYS A 1 578 ? -6.435  -68.937 -24.232 0.48 40.71  ? 841  LYS A CG  1 
ATOM   4388 C  CD  . LYS A 1 578 ? -5.948  -70.384 -24.136 0.48 42.74  ? 841  LYS A CD  1 
ATOM   4389 C  CE  . LYS A 1 578 ? -7.064  -71.408 -24.140 0.48 45.83  ? 841  LYS A CE  1 
ATOM   4390 N  NZ  . LYS A 1 578 ? -6.684  -72.665 -23.450 0.48 48.28  ? 841  LYS A NZ  1 
ATOM   4391 N  N   . ARG A 1 579 ? -3.518  -65.391 -23.844 1.00 30.45  ? 842  ARG A N   1 
ATOM   4392 C  CA  . ARG A 1 579 ? -2.360  -64.636 -23.287 1.00 32.49  ? 842  ARG A CA  1 
ATOM   4393 C  C   . ARG A 1 579 ? -2.670  -63.131 -23.264 1.00 30.10  ? 842  ARG A C   1 
ATOM   4394 O  O   . ARG A 1 579 ? -2.364  -62.462 -22.249 1.00 29.39  ? 842  ARG A O   1 
ATOM   4395 C  CB  . ARG A 1 579 ? -1.033  -64.991 -23.984 1.00 28.89  ? 842  ARG A CB  1 
ATOM   4396 C  CG  . ARG A 1 579 ? 0.200   -64.471 -23.265 1.00 29.87  ? 842  ARG A CG  1 
ATOM   4397 C  CD  . ARG A 1 579 ? 1.574   -64.867 -23.870 1.00 33.99  ? 842  ARG A CD  1 
ATOM   4398 N  NE  . ARG A 1 579 ? 1.613   -66.296 -24.071 1.00 33.35  ? 842  ARG A NE  1 
ATOM   4399 C  CZ  . ARG A 1 579 ? 1.765   -67.156 -23.091 1.00 40.61  ? 842  ARG A CZ  1 
ATOM   4400 N  NH1 . ARG A 1 579 ? 1.583   -68.454 -23.308 1.00 45.29  ? 842  ARG A NH1 1 
ATOM   4401 N  NH2 . ARG A 1 579 ? 2.053   -66.703 -21.886 1.00 39.77  ? 842  ARG A NH2 1 
ATOM   4402 N  N   . GLU A 1 580 ? -3.256  -62.612 -24.348 0.48 31.73  ? 843  GLU A N   1 
ATOM   4403 C  CA  . GLU A 1 580 ? -3.744  -61.206 -24.432 0.48 32.83  ? 843  GLU A CA  1 
ATOM   4404 C  C   . GLU A 1 580 ? -4.751  -60.953 -23.295 0.48 30.30  ? 843  GLU A C   1 
ATOM   4405 O  O   . GLU A 1 580 ? -4.674  -59.893 -22.675 0.48 29.48  ? 843  GLU A O   1 
ATOM   4406 C  CB  . GLU A 1 580 ? -4.378  -60.929 -25.795 0.48 35.54  ? 843  GLU A CB  1 
ATOM   4407 C  CG  . GLU A 1 580 ? -3.417  -61.070 -26.966 0.48 39.07  ? 843  GLU A CG  1 
ATOM   4408 C  CD  . GLU A 1 580 ? -3.925  -60.484 -28.278 0.48 42.19  ? 843  GLU A CD  1 
ATOM   4409 O  OE1 . GLU A 1 580 ? -5.163  -60.397 -28.451 0.48 44.86  ? 843  GLU A OE1 1 
ATOM   4410 O  OE2 . GLU A 1 580 ? -3.082  -60.103 -29.123 0.48 43.14  ? 843  GLU A OE2 1 
ATOM   4411 N  N   . ASP A 1 581 ? -5.625  -61.920 -23.003 1.00 28.79  ? 844  ASP A N   1 
ATOM   4412 C  CA  . ASP A 1 581 ? -6.660  -61.794 -21.943 1.00 30.59  ? 844  ASP A CA  1 
ATOM   4413 C  C   . ASP A 1 581 ? -5.986  -61.666 -20.581 1.00 30.93  ? 844  ASP A C   1 
ATOM   4414 O  O   . ASP A 1 581 ? -6.387  -60.783 -19.771 1.00 30.06  ? 844  ASP A O   1 
ATOM   4415 C  CB  . ASP A 1 581 ? -7.690  -62.915 -22.005 1.00 32.38  ? 844  ASP A CB  1 
ATOM   4416 C  CG  . ASP A 1 581 ? -9.093  -62.578 -21.482 1.00 32.57  ? 844  ASP A CG  1 
ATOM   4417 O  OD1 . ASP A 1 581 ? -9.299  -61.490 -20.849 1.00 29.34  ? 844  ASP A OD1 1 
ATOM   4418 O  OD2 . ASP A 1 581 ? -9.983  -63.415 -21.724 1.00 32.55  ? 844  ASP A OD2 1 
ATOM   4419 N  N   . GLN A 1 582 ? -4.960  -62.486 -20.339 0.48 30.18  ? 845  GLN A N   1 
ATOM   4420 C  CA  . GLN A 1 582 ? -4.238  -62.488 -19.035 0.48 30.05  ? 845  GLN A CA  1 
ATOM   4421 C  C   . GLN A 1 582 ? -3.412  -61.203 -18.891 0.48 28.73  ? 845  GLN A C   1 
ATOM   4422 O  O   . GLN A 1 582 ? -3.387  -60.661 -17.777 0.48 29.05  ? 845  GLN A O   1 
ATOM   4423 C  CB  . GLN A 1 582 ? -3.367  -63.745 -18.972 0.48 30.33  ? 845  GLN A CB  1 
ATOM   4424 C  CG  . GLN A 1 582 ? -2.764  -64.035 -17.607 0.48 31.28  ? 845  GLN A CG  1 
ATOM   4425 C  CD  . GLN A 1 582 ? -1.865  -65.246 -17.670 0.48 32.60  ? 845  GLN A CD  1 
ATOM   4426 O  OE1 . GLN A 1 582 ? -0.814  -65.228 -18.308 0.48 31.29  ? 845  GLN A OE1 1 
ATOM   4427 N  NE2 . GLN A 1 582 ? -2.278  -66.317 -17.013 0.48 30.96  ? 845  GLN A NE2 1 
ATOM   4428 N  N   . TRP A 1 583 ? -2.758  -60.749 -19.967 1.00 27.66  ? 846  TRP A N   1 
ATOM   4429 C  CA  . TRP A 1 583 ? -2.008  -59.461 -19.953 1.00 27.10  ? 846  TRP A CA  1 
ATOM   4430 C  C   . TRP A 1 583 ? -2.918  -58.301 -19.531 1.00 31.54  ? 846  TRP A C   1 
ATOM   4431 O  O   . TRP A 1 583 ? -2.423  -57.380 -18.812 1.00 29.41  ? 846  TRP A O   1 
ATOM   4432 C  CB  . TRP A 1 583 ? -1.390  -59.143 -21.317 1.00 27.77  ? 846  TRP A CB  1 
ATOM   4433 C  CG  . TRP A 1 583 ? -0.197  -59.982 -21.668 1.00 28.80  ? 846  TRP A CG  1 
ATOM   4434 C  CD1 . TRP A 1 583 ? 0.616   -60.650 -20.805 1.00 30.12  ? 846  TRP A CD1 1 
ATOM   4435 C  CD2 . TRP A 1 583 ? 0.281   -60.302 -22.990 1.00 27.08  ? 846  TRP A CD2 1 
ATOM   4436 N  NE1 . TRP A 1 583 ? 1.587   -61.334 -21.495 1.00 31.20  ? 846  TRP A NE1 1 
ATOM   4437 C  CE2 . TRP A 1 583 ? 1.410   -61.132 -22.837 1.00 28.87  ? 846  TRP A CE2 1 
ATOM   4438 C  CE3 . TRP A 1 583 ? -0.095  -59.929 -24.282 1.00 30.09  ? 846  TRP A CE3 1 
ATOM   4439 C  CZ2 . TRP A 1 583 ? 2.144   -61.612 -23.927 1.00 33.67  ? 846  TRP A CZ2 1 
ATOM   4440 C  CZ3 . TRP A 1 583 ? 0.605   -60.422 -25.372 1.00 33.22  ? 846  TRP A CZ3 1 
ATOM   4441 C  CH2 . TRP A 1 583 ? 1.730   -61.237 -25.191 1.00 34.74  ? 846  TRP A CH2 1 
ATOM   4442 N  N   . CYS A 1 584 ? -4.185  -58.296 -19.980 1.00 27.62  ? 847  CYS A N   1 
ATOM   4443 C  CA  . CYS A 1 584 ? -5.118  -57.188 -19.651 1.00 28.36  ? 847  CYS A CA  1 
ATOM   4444 C  C   . CYS A 1 584 ? -5.878  -57.530 -18.381 1.00 25.90  ? 847  CYS A C   1 
ATOM   4445 O  O   . CYS A 1 584 ? -6.892  -56.904 -18.150 1.00 28.22  ? 847  CYS A O   1 
ATOM   4446 C  CB  . CYS A 1 584 ? -6.030  -56.847 -20.818 1.00 29.79  ? 847  CYS A CB  1 
ATOM   4447 S  SG  . CYS A 1 584 ? -5.062  -56.193 -22.186 1.00 31.31  ? 847  CYS A SG  1 
ATOM   4448 N  N   . GLY A 1 585 ? -5.404  -58.508 -17.605 1.00 29.36  ? 848  GLY A N   1 
ATOM   4449 C  CA  . GLY A 1 585 ? -5.817  -58.690 -16.195 1.00 28.02  ? 848  GLY A CA  1 
ATOM   4450 C  C   . GLY A 1 585 ? -6.713  -59.889 -15.890 1.00 28.16  ? 848  GLY A C   1 
ATOM   4451 O  O   . GLY A 1 585 ? -7.157  -60.021 -14.734 1.00 31.51  ? 848  GLY A O   1 
ATOM   4452 N  N   . SER A 1 586 ? -6.958  -60.766 -16.870 0.48 27.75  ? 849  SER A N   1 
ATOM   4453 C  CA  . SER A 1 586 ? -7.808  -61.974 -16.706 0.48 28.43  ? 849  SER A CA  1 
ATOM   4454 C  C   . SER A 1 586 ? -7.255  -62.881 -15.595 0.48 30.41  ? 849  SER A C   1 
ATOM   4455 O  O   . SER A 1 586 ? -6.010  -63.002 -15.479 0.48 30.06  ? 849  SER A O   1 
ATOM   4456 C  CB  . SER A 1 586 ? -7.928  -62.732 -17.989 0.48 28.33  ? 849  SER A CB  1 
ATOM   4457 O  OG  . SER A 1 586 ? -8.785  -63.849 -17.824 0.48 28.64  ? 849  SER A OG  1 
ATOM   4458 N  N   . LEU A 1 587 ? -8.160  -63.529 -14.851 0.48 30.42  ? 850  LEU A N   1 
ATOM   4459 C  CA  . LEU A 1 587 ? -7.856  -64.500 -13.763 0.48 29.99  ? 850  LEU A CA  1 
ATOM   4460 C  C   . LEU A 1 587 ? -7.940  -65.949 -14.293 0.48 30.34  ? 850  LEU A C   1 
ATOM   4461 O  O   . LEU A 1 587 ? -7.942  -66.899 -13.439 0.48 31.02  ? 850  LEU A O   1 
ATOM   4462 C  CB  . LEU A 1 587 ? -8.851  -64.297 -12.609 0.48 29.10  ? 850  LEU A CB  1 
ATOM   4463 C  CG  . LEU A 1 587 ? -8.801  -62.949 -11.898 0.48 30.64  ? 850  LEU A CG  1 
ATOM   4464 C  CD1 . LEU A 1 587 ? -9.512  -63.030 -10.551 0.48 32.02  ? 850  LEU A CD1 1 
ATOM   4465 C  CD2 . LEU A 1 587 ? -7.367  -62.473 -11.706 0.48 30.77  ? 850  LEU A CD2 1 
ATOM   4466 N  N   . ILE A 1 588 ? -8.058  -66.139 -15.621 0.48 29.49  ? 851  ILE A N   1 
ATOM   4467 C  CA  . ILE A 1 588 ? -8.068  -67.509 -16.228 0.48 31.39  ? 851  ILE A CA  1 
ATOM   4468 C  C   . ILE A 1 588 ? -6.753  -68.209 -15.831 0.48 33.26  ? 851  ILE A C   1 
ATOM   4469 O  O   . ILE A 1 588 ? -5.691  -67.528 -15.774 0.48 30.56  ? 851  ILE A O   1 
ATOM   4470 C  CB  . ILE A 1 588 ? -8.277  -67.510 -17.761 0.48 29.99  ? 851  ILE A CB  1 
ATOM   4471 C  CG1 . ILE A 1 588 ? -7.214  -66.683 -18.493 0.48 30.07  ? 851  ILE A CG1 1 
ATOM   4472 C  CG2 . ILE A 1 588 ? -9.688  -67.079 -18.117 0.48 29.39  ? 851  ILE A CG2 1 
ATOM   4473 C  CD1 . ILE A 1 588 ? -7.309  -66.731 -20.004 0.48 29.60  ? 851  ILE A CD1 1 
ATOM   4474 N  N   . GLY A 1 589 ? -6.828  -69.514 -15.537 0.48 35.92  ? 852  GLY A N   1 
ATOM   4475 C  CA  . GLY A 1 589 ? -5.667  -70.335 -15.139 0.48 37.05  ? 852  GLY A CA  1 
ATOM   4476 C  C   . GLY A 1 589 ? -5.367  -70.241 -13.650 0.48 38.14  ? 852  GLY A C   1 
ATOM   4477 O  O   . GLY A 1 589 ? -4.448  -70.942 -13.210 0.48 40.38  ? 852  GLY A O   1 
ATOM   4478 N  N   . LEU A 1 590 ? -6.087  -69.406 -12.891 0.48 38.25  ? 853  LEU A N   1 
ATOM   4479 C  CA  . LEU A 1 590 ? -6.039  -69.427 -11.404 0.48 38.64  ? 853  LEU A CA  1 
ATOM   4480 C  C   . LEU A 1 590 ? -7.117  -70.387 -10.891 0.48 40.24  ? 853  LEU A C   1 
ATOM   4481 O  O   . LEU A 1 590 ? -8.141  -70.582 -11.584 0.48 38.16  ? 853  LEU A O   1 
ATOM   4482 C  CB  . LEU A 1 590 ? -6.247  -68.026 -10.820 0.48 39.36  ? 853  LEU A CB  1 
ATOM   4483 C  CG  . LEU A 1 590 ? -5.217  -66.963 -11.202 0.48 41.32  ? 853  LEU A CG  1 
ATOM   4484 C  CD1 . LEU A 1 590 ? -5.514  -65.659 -10.479 0.48 42.75  ? 853  LEU A CD1 1 
ATOM   4485 C  CD2 . LEU A 1 590 ? -3.794  -67.417 -10.903 0.48 40.82  ? 853  LEU A CD2 1 
ATOM   4486 N  N   . THR A 1 591 ? -6.884  -70.946 -9.703  1.00 42.38  ? 854  THR A N   1 
ATOM   4487 C  CA  . THR A 1 591 ? -7.746  -71.968 -9.078  1.00 43.37  ? 854  THR A CA  1 
ATOM   4488 C  C   . THR A 1 591 ? -9.028  -71.285 -8.632  1.00 34.63  ? 854  THR A C   1 
ATOM   4489 O  O   . THR A 1 591 ? -10.090 -71.853 -8.875  1.00 41.63  ? 854  THR A O   1 
ATOM   4490 C  CB  . THR A 1 591 ? -6.943  -72.653 -7.957  1.00 39.29  ? 854  THR A CB  1 
ATOM   4491 O  OG1 . THR A 1 591 ? -5.891  -73.310 -8.644  1.00 50.79  ? 854  THR A OG1 1 
ATOM   4492 C  CG2 . THR A 1 591 ? -7.708  -73.682 -7.167  1.00 44.43  ? 854  THR A CG2 1 
ATOM   4493 N  N   . SER A 1 592 ? -8.909  -70.110 -8.023  1.00 36.58  ? 855  SER A N   1 
ATOM   4494 C  CA  . SER A 1 592 ? -10.059 -69.321 -7.505  1.00 35.30  ? 855  SER A CA  1 
ATOM   4495 C  C   . SER A 1 592 ? -11.040 -69.056 -8.658  1.00 36.99  ? 855  SER A C   1 
ATOM   4496 O  O   . SER A 1 592 ? -12.254 -69.182 -8.471  1.00 38.96  ? 855  SER A O   1 
ATOM   4497 C  CB  . SER A 1 592 ? -9.620  -68.056 -6.828  1.00 33.34  ? 855  SER A CB  1 
ATOM   4498 O  OG  . SER A 1 592 ? -8.880  -67.225 -7.710  1.00 38.09  ? 855  SER A OG  1 
ATOM   4499 N  N   . ARG A 1 593 ? -10.521 -68.752 -9.829  1.00 34.68  ? 856  ARG A N   1 
ATOM   4500 C  CA  . ARG A 1 593 ? -11.341 -68.431 -11.005 1.00 36.79  ? 856  ARG A CA  1 
ATOM   4501 C  C   . ARG A 1 593 ? -12.033 -69.704 -11.496 1.00 39.08  ? 856  ARG A C   1 
ATOM   4502 O  O   . ARG A 1 593 ? -13.198 -69.595 -11.865 1.00 33.58  ? 856  ARG A O   1 
ATOM   4503 C  CB  . ARG A 1 593 ? -10.480 -67.764 -12.076 1.00 33.63  ? 856  ARG A CB  1 
ATOM   4504 C  CG  . ARG A 1 593 ? -11.311 -67.138 -13.180 1.00 34.34  ? 856  ARG A CG  1 
ATOM   4505 C  CD  . ARG A 1 593 ? -11.642 -68.113 -14.281 1.00 35.59  ? 856  ARG A CD  1 
ATOM   4506 N  NE  . ARG A 1 593 ? -12.102 -67.388 -15.447 1.00 39.51  ? 856  ARG A NE  1 
ATOM   4507 C  CZ  . ARG A 1 593 ? -12.887 -67.895 -16.382 1.00 36.06  ? 856  ARG A CZ  1 
ATOM   4508 N  NH1 . ARG A 1 593 ? -13.189 -69.176 -16.334 1.00 36.86  ? 856  ARG A NH1 1 
ATOM   4509 N  NH2 . ARG A 1 593 ? -13.283 -67.144 -17.402 1.00 30.93  ? 856  ARG A NH2 1 
ATOM   4510 N  N   . ALA A 1 594 ? -11.339 -70.844 -11.553 1.00 34.85  ? 857  ALA A N   1 
ATOM   4511 C  CA  . ALA A 1 594 ? -11.909 -72.132 -12.027 1.00 38.27  ? 857  ALA A CA  1 
ATOM   4512 C  C   . ALA A 1 594 ? -13.018 -72.611 -11.070 1.00 36.25  ? 857  ALA A C   1 
ATOM   4513 O  O   . ALA A 1 594 ? -14.047 -73.103 -11.525 1.00 30.92  ? 857  ALA A O   1 
ATOM   4514 C  CB  . ALA A 1 594 ? -10.826 -73.170 -12.126 1.00 44.43  ? 857  ALA A CB  1 
ATOM   4515 N  N   . THR A 1 595 ? -12.841 -72.449 -9.774  1.00 32.42  ? 858  THR A N   1 
ATOM   4516 C  CA  . THR A 1 595 ? -13.896 -72.808 -8.804  1.00 37.73  ? 858  THR A CA  1 
ATOM   4517 C  C   . THR A 1 595 ? -15.110 -71.909 -9.035  1.00 38.58  ? 858  THR A C   1 
ATOM   4518 O  O   . THR A 1 595 ? -16.269 -72.400 -9.003  1.00 40.66  ? 858  THR A O   1 
ATOM   4519 C  CB  . THR A 1 595 ? -13.411 -72.636 -7.369  1.00 38.90  ? 858  THR A CB  1 
ATOM   4520 O  OG1 . THR A 1 595 ? -12.233 -73.434 -7.298  1.00 50.73  ? 858  THR A OG1 1 
ATOM   4521 C  CG2 . THR A 1 595 ? -14.419 -73.120 -6.364  1.00 39.68  ? 858  THR A CG2 1 
ATOM   4522 N  N   . TRP A 1 596 ? -14.847 -70.623 -9.212  1.00 37.23  ? 859  TRP A N   1 
ATOM   4523 C  CA  . TRP A 1 596 ? -15.907 -69.622 -9.431  1.00 34.53  ? 859  TRP A CA  1 
ATOM   4524 C  C   . TRP A 1 596 ? -16.711 -70.036 -10.670 1.00 34.13  ? 859  TRP A C   1 
ATOM   4525 O  O   . TRP A 1 596 ? -17.925 -70.084 -10.559 1.00 30.87  ? 859  TRP A O   1 
ATOM   4526 C  CB  . TRP A 1 596 ? -15.302 -68.230 -9.556  1.00 32.29  ? 859  TRP A CB  1 
ATOM   4527 C  CG  . TRP A 1 596 ? -16.191 -67.157 -10.096 1.00 28.07  ? 859  TRP A CG  1 
ATOM   4528 C  CD1 . TRP A 1 596 ? -17.223 -66.540 -9.460  1.00 30.72  ? 859  TRP A CD1 1 
ATOM   4529 C  CD2 . TRP A 1 596 ? -16.042 -66.499 -11.354 1.00 29.91  ? 859  TRP A CD2 1 
ATOM   4530 N  NE1 . TRP A 1 596 ? -17.723 -65.532 -10.233 1.00 30.96  ? 859  TRP A NE1 1 
ATOM   4531 C  CE2 . TRP A 1 596 ? -17.040 -65.500 -11.414 1.00 28.44  ? 859  TRP A CE2 1 
ATOM   4532 C  CE3 . TRP A 1 596 ? -15.147 -66.651 -12.421 1.00 30.12  ? 859  TRP A CE3 1 
ATOM   4533 C  CZ2 . TRP A 1 596 ? -17.167 -64.628 -12.486 1.00 28.09  ? 859  TRP A CZ2 1 
ATOM   4534 C  CZ3 . TRP A 1 596 ? -15.259 -65.778 -13.490 1.00 34.67  ? 859  TRP A CZ3 1 
ATOM   4535 C  CH2 . TRP A 1 596 ? -16.286 -64.804 -13.532 1.00 35.07  ? 859  TRP A CH2 1 
ATOM   4536 N  N   . ALA A 1 597 ? -16.055 -70.287 -11.797 1.00 34.06  ? 860  ALA A N   1 
ATOM   4537 C  CA  . ALA A 1 597 ? -16.731 -70.587 -13.082 1.00 39.36  ? 860  ALA A CA  1 
ATOM   4538 C  C   . ALA A 1 597 ? -17.546 -71.888 -12.970 1.00 37.85  ? 860  ALA A C   1 
ATOM   4539 O  O   . ALA A 1 597 ? -18.648 -71.959 -13.498 1.00 47.72  ? 860  ALA A O   1 
ATOM   4540 C  CB  . ALA A 1 597 ? -15.682 -70.666 -14.181 1.00 36.93  ? 860  ALA A CB  1 
ATOM   4541 N  N   . LYS A 1 598 ? -17.004 -72.897 -12.302 1.00 40.23  ? 861  LYS A N   1 
ATOM   4542 C  CA  . LYS A 1 598 ? -17.578 -74.260 -12.280 1.00 41.18  ? 861  LYS A CA  1 
ATOM   4543 C  C   . LYS A 1 598 ? -18.801 -74.227 -11.375 1.00 37.63  ? 861  LYS A C   1 
ATOM   4544 O  O   . LYS A 1 598 ? -19.766 -74.892 -11.718 1.00 39.61  ? 861  LYS A O   1 
ATOM   4545 C  CB  . LYS A 1 598 ? -16.518 -75.280 -11.830 1.00 49.54  ? 861  LYS A CB  1 
ATOM   4546 C  CG  . LYS A 1 598 ? -17.033 -76.537 -11.137 1.00 63.03  ? 861  LYS A CG  1 
ATOM   4547 C  CD  . LYS A 1 598 ? -15.965 -77.599 -10.883 1.00 70.66  ? 861  LYS A CD  1 
ATOM   4548 C  CE  . LYS A 1 598 ? -15.802 -78.570 -12.043 1.00 79.69  ? 861  LYS A CE  1 
ATOM   4549 N  NZ  . LYS A 1 598 ? -17.043 -79.346 -12.299 1.00 79.68  ? 861  LYS A NZ  1 
ATOM   4550 N  N   . ASN A 1 599 ? -18.748 -73.474 -10.280 1.00 34.06  ? 862  ASN A N   1 
ATOM   4551 C  CA  . ASN A 1 599 ? -19.852 -73.352 -9.282  1.00 36.98  ? 862  ASN A CA  1 
ATOM   4552 C  C   . ASN A 1 599 ? -20.655 -72.063 -9.470  1.00 33.26  ? 862  ASN A C   1 
ATOM   4553 O  O   . ASN A 1 599 ? -21.210 -71.598 -8.481  1.00 39.92  ? 862  ASN A O   1 
ATOM   4554 C  CB  . ASN A 1 599 ? -19.325 -73.384 -7.838  1.00 33.70  ? 862  ASN A CB  1 
ATOM   4555 C  CG  . ASN A 1 599 ? -18.631 -74.701 -7.584  1.00 36.47  ? 862  ASN A CG  1 
ATOM   4556 O  OD1 . ASN A 1 599 ? -19.211 -75.744 -7.805  1.00 45.66  ? 862  ASN A OD1 1 
ATOM   4557 N  ND2 . ASN A 1 599 ? -17.401 -74.669 -7.143  1.00 43.02  ? 862  ASN A ND2 1 
ATOM   4558 N  N   . ILE A 1 600 ? -20.713 -71.496 -10.672 1.00 35.18  ? 863  ILE A N   1 
ATOM   4559 C  CA  . ILE A 1 600 ? -21.391 -70.172 -10.900 1.00 33.96  ? 863  ILE A CA  1 
ATOM   4560 C  C   . ILE A 1 600 ? -22.890 -70.237 -10.546 1.00 34.09  ? 863  ILE A C   1 
ATOM   4561 O  O   . ILE A 1 600 ? -23.414 -69.247 -10.012 1.00 32.98  ? 863  ILE A O   1 
ATOM   4562 C  CB  . ILE A 1 600 ? -21.134 -69.640 -12.318 1.00 31.69  ? 863  ILE A CB  1 
ATOM   4563 C  CG1 . ILE A 1 600 ? -21.393 -68.135 -12.408 1.00 36.19  ? 863  ILE A CG1 1 
ATOM   4564 C  CG2 . ILE A 1 600 ? -21.927 -70.399 -13.359 1.00 32.65  ? 863  ILE A CG2 1 
ATOM   4565 C  CD1 . ILE A 1 600 ? -20.501 -67.269 -11.536 1.00 34.23  ? 863  ILE A CD1 1 
ATOM   4566 N  N   A GLN A 1 601 ? -23.550 -71.373 -10.804 0.25 33.73  ? 864  GLN A N   1 
ATOM   4567 N  N   B GLN A 1 601 ? -23.546 -71.375 -10.804 0.25 34.64  ? 864  GLN A N   1 
ATOM   4568 C  CA  A GLN A 1 601 ? -25.014 -71.550 -10.567 0.25 34.64  ? 864  GLN A CA  1 
ATOM   4569 C  CA  B GLN A 1 601 ? -25.008 -71.557 -10.564 0.25 36.18  ? 864  GLN A CA  1 
ATOM   4570 C  C   A GLN A 1 601 ? -25.336 -71.430 -9.066  0.25 34.22  ? 864  GLN A C   1 
ATOM   4571 C  C   B GLN A 1 601 ? -25.329 -71.417 -9.066  0.25 35.09  ? 864  GLN A C   1 
ATOM   4572 O  O   A GLN A 1 601 ? -26.438 -70.961 -8.744  0.25 32.84  ? 864  GLN A O   1 
ATOM   4573 O  O   B GLN A 1 601 ? -26.425 -70.930 -8.748  0.25 33.57  ? 864  GLN A O   1 
ATOM   4574 C  CB  A GLN A 1 601 ? -25.511 -72.871 -11.157 0.25 33.85  ? 864  GLN A CB  1 
ATOM   4575 C  CB  B GLN A 1 601 ? -25.501 -72.897 -11.111 0.25 36.57  ? 864  GLN A CB  1 
ATOM   4576 C  CG  A GLN A 1 601 ? -25.548 -72.876 -12.681 0.25 33.21  ? 864  GLN A CG  1 
ATOM   4577 C  CG  B GLN A 1 601 ? -27.014 -73.052 -11.028 0.25 36.78  ? 864  GLN A CG  1 
ATOM   4578 C  CD  A GLN A 1 601 ? -26.598 -71.967 -13.267 0.25 32.32  ? 864  GLN A CD  1 
ATOM   4579 C  CD  B GLN A 1 601 ? -27.762 -71.846 -11.539 0.25 38.41  ? 864  GLN A CD  1 
ATOM   4580 O  OE1 A GLN A 1 601 ? -27.596 -71.644 -12.631 0.25 35.06  ? 864  GLN A OE1 1 
ATOM   4581 O  OE1 B GLN A 1 601 ? -27.478 -71.324 -12.619 0.25 40.68  ? 864  GLN A OE1 1 
ATOM   4582 N  NE2 A GLN A 1 601 ? -26.391 -71.564 -14.508 0.25 32.14  ? 864  GLN A NE2 1 
ATOM   4583 N  NE2 B GLN A 1 601 ? -28.742 -71.403 -10.766 0.25 36.90  ? 864  GLN A NE2 1 
ATOM   4584 N  N   . THR A 1 602 ? -24.412 -71.816 -8.185  1.00 34.24  ? 865  THR A N   1 
ATOM   4585 C  CA  . THR A 1 602 ? -24.546 -71.602 -6.716  1.00 36.28  ? 865  THR A CA  1 
ATOM   4586 C  C   . THR A 1 602 ? -24.469 -70.110 -6.345  1.00 35.91  ? 865  THR A C   1 
ATOM   4587 O  O   . THR A 1 602 ? -25.115 -69.687 -5.342  1.00 37.43  ? 865  THR A O   1 
ATOM   4588 C  CB  . THR A 1 602 ? -23.403 -72.307 -5.981  1.00 36.52  ? 865  THR A CB  1 
ATOM   4589 O  OG1 . THR A 1 602 ? -23.561 -73.697 -6.254  1.00 40.59  ? 865  THR A OG1 1 
ATOM   4590 C  CG2 . THR A 1 602 ? -23.389 -72.036 -4.498  1.00 39.87  ? 865  THR A CG2 1 
ATOM   4591 N  N   . ALA A 1 603 ? -23.650 -69.318 -7.034  1.00 35.01  ? 866  ALA A N   1 
ATOM   4592 C  CA  . ALA A 1 603 ? -23.538 -67.880 -6.710  1.00 32.89  ? 866  ALA A CA  1 
ATOM   4593 C  C   . ALA A 1 603 ? -24.789 -67.208 -7.249  1.00 29.48  ? 866  ALA A C   1 
ATOM   4594 O  O   . ALA A 1 603 ? -25.416 -66.455 -6.539  1.00 31.13  ? 866  ALA A O   1 
ATOM   4595 C  CB  . ALA A 1 603 ? -22.286 -67.291 -7.290  1.00 32.60  ? 866  ALA A CB  1 
ATOM   4596 N  N   . ILE A 1 604 ? -25.168 -67.532 -8.476  1.00 30.88  ? 867  ILE A N   1 
ATOM   4597 C  CA  . ILE A 1 604 ? -26.430 -67.030 -9.083  1.00 32.65  ? 867  ILE A CA  1 
ATOM   4598 C  C   . ILE A 1 604 ? -27.581 -67.335 -8.116  1.00 33.02  ? 867  ILE A C   1 
ATOM   4599 O  O   . ILE A 1 604 ? -28.403 -66.437 -7.899  1.00 33.75  ? 867  ILE A O   1 
ATOM   4600 C  CB  . ILE A 1 604 ? -26.633 -67.669 -10.466 1.00 34.33  ? 867  ILE A CB  1 
ATOM   4601 C  CG1 . ILE A 1 604 ? -25.552 -67.178 -11.429 1.00 32.84  ? 867  ILE A CG1 1 
ATOM   4602 C  CG2 . ILE A 1 604 ? -28.026 -67.379 -10.984 1.00 33.41  ? 867  ILE A CG2 1 
ATOM   4603 C  CD1 . ILE A 1 604 ? -25.589 -67.801 -12.807 1.00 37.40  ? 867  ILE A CD1 1 
ATOM   4604 N  N   . ASN A 1 605 ? -27.628 -68.544 -7.531  1.00 33.71  ? 868  ASN A N   1 
ATOM   4605 C  CA  . ASN A 1 605 ? -28.750 -68.957 -6.649  1.00 34.81  ? 868  ASN A CA  1 
ATOM   4606 C  C   . ASN A 1 605 ? -28.685 -68.149 -5.342  1.00 39.05  ? 868  ASN A C   1 
ATOM   4607 O  O   . ASN A 1 605 ? -29.763 -67.800 -4.831  1.00 37.17  ? 868  ASN A O   1 
ATOM   4608 C  CB  . ASN A 1 605 ? -28.832 -70.466 -6.424  1.00 39.43  ? 868  ASN A CB  1 
ATOM   4609 C  CG  . ASN A 1 605 ? -29.378 -71.215 -7.628  1.00 48.70  ? 868  ASN A CG  1 
ATOM   4610 O  OD1 . ASN A 1 605 ? -30.154 -70.702 -8.428  1.00 54.08  ? 868  ASN A OD1 1 
ATOM   4611 N  ND2 . ASN A 1 605 ? -28.925 -72.440 -7.808  1.00 60.66  ? 868  ASN A ND2 1 
ATOM   4612 N  N   . GLN A 1 606 ? -27.495 -67.850 -4.802  1.00 37.57  ? 869  GLN A N   1 
ATOM   4613 C  CA  . GLN A 1 606 ? -27.408 -67.039 -3.560  1.00 36.64  ? 869  GLN A CA  1 
ATOM   4614 C  C   . GLN A 1 606 ? -28.127 -65.685 -3.771  1.00 36.34  ? 869  GLN A C   1 
ATOM   4615 O  O   . GLN A 1 606 ? -28.877 -65.253 -2.869  1.00 32.42  ? 869  GLN A O   1 
ATOM   4616 C  CB  . GLN A 1 606 ? -25.963 -66.823 -3.130  1.00 38.09  ? 869  GLN A CB  1 
ATOM   4617 C  CG  . GLN A 1 606 ? -25.872 -65.935 -1.889  1.00 44.69  ? 869  GLN A CG  1 
ATOM   4618 C  CD  . GLN A 1 606 ? -24.459 -65.667 -1.421  1.00 53.08  ? 869  GLN A CD  1 
ATOM   4619 O  OE1 . GLN A 1 606 ? -23.503 -65.735 -2.209  1.00 53.83  ? 869  GLN A OE1 1 
ATOM   4620 N  NE2 . GLN A 1 606 ? -24.325 -65.390 -0.125  1.00 47.13  ? 869  GLN A NE2 1 
ATOM   4621 N  N   . VAL A 1 607 ? -27.876 -65.017 -4.898  1.00 30.25  ? 870  VAL A N   1 
ATOM   4622 C  CA  . VAL A 1 607 ? -28.408 -63.660 -5.181  1.00 32.88  ? 870  VAL A CA  1 
ATOM   4623 C  C   . VAL A 1 607 ? -29.922 -63.785 -5.459  1.00 31.64  ? 870  VAL A C   1 
ATOM   4624 O  O   . VAL A 1 607 ? -30.691 -62.963 -4.915  1.00 30.82  ? 870  VAL A O   1 
ATOM   4625 C  CB  . VAL A 1 607 ? -27.641 -63.012 -6.348  1.00 33.98  ? 870  VAL A CB  1 
ATOM   4626 C  CG1 . VAL A 1 607 ? -28.384 -61.831 -6.928  1.00 32.33  ? 870  VAL A CG1 1 
ATOM   4627 C  CG2 . VAL A 1 607 ? -26.228 -62.636 -5.913  1.00 35.48  ? 870  VAL A CG2 1 
ATOM   4628 N  N   . ARG A 1 608 ? -30.342 -64.796 -6.216  1.00 30.34  ? 871  ARG A N   1 
ATOM   4629 C  CA  . ARG A 1 608 ? -31.792 -65.070 -6.473  1.00 31.80  ? 871  ARG A CA  1 
ATOM   4630 C  C   . ARG A 1 608 ? -32.534 -65.276 -5.143  1.00 33.19  ? 871  ARG A C   1 
ATOM   4631 O  O   . ARG A 1 608 ? -33.644 -64.743 -5.016  1.00 38.36  ? 871  ARG A O   1 
ATOM   4632 C  CB  . ARG A 1 608 ? -31.995 -66.287 -7.371  1.00 31.27  ? 871  ARG A CB  1 
ATOM   4633 C  CG  . ARG A 1 608 ? -31.619 -66.051 -8.820  1.00 34.13  ? 871  ARG A CG  1 
ATOM   4634 C  CD  . ARG A 1 608 ? -31.810 -67.315 -9.629  1.00 36.50  ? 871  ARG A CD  1 
ATOM   4635 N  NE  . ARG A 1 608 ? -31.741 -67.062 -11.056 1.00 36.23  ? 871  ARG A NE  1 
ATOM   4636 C  CZ  . ARG A 1 608 ? -31.616 -68.012 -11.969 1.00 41.12  ? 871  ARG A CZ  1 
ATOM   4637 N  NH1 . ARG A 1 608 ? -31.580 -69.274 -11.586 1.00 50.40  ? 871  ARG A NH1 1 
ATOM   4638 N  NH2 . ARG A 1 608 ? -31.548 -67.718 -13.257 1.00 38.42  ? 871  ARG A NH2 1 
ATOM   4639 N  N   . SER A 1 609 ? -31.951 -65.988 -4.186  1.00 30.66  ? 872  SER A N   1 
ATOM   4640 C  CA  . SER A 1 609 ? -32.575 -66.207 -2.856  1.00 33.61  ? 872  SER A CA  1 
ATOM   4641 C  C   . SER A 1 609 ? -32.707 -64.895 -2.092  1.00 31.61  ? 872  SER A C   1 
ATOM   4642 O  O   . SER A 1 609 ? -33.665 -64.750 -1.363  1.00 39.22  ? 872  SER A O   1 
ATOM   4643 C  CB  . SER A 1 609 ? -31.805 -67.220 -2.039  1.00 36.31  ? 872  SER A CB  1 
ATOM   4644 O  OG  . SER A 1 609 ? -31.645 -68.447 -2.770  1.00 36.51  ? 872  SER A OG  1 
ATOM   4645 N  N   . LEU A 1 610 ? -31.770 -63.971 -2.219  1.00 33.61  ? 873  LEU A N   1 
ATOM   4646 C  CA  . LEU A 1 610 ? -31.813 -62.675 -1.487  1.00 34.16  ? 873  LEU A CA  1 
ATOM   4647 C  C   . LEU A 1 610 ? -32.906 -61.783 -2.097  1.00 34.05  ? 873  LEU A C   1 
ATOM   4648 O  O   . LEU A 1 610 ? -33.635 -61.169 -1.338  1.00 32.40  ? 873  LEU A O   1 
ATOM   4649 C  CB  . LEU A 1 610 ? -30.436 -62.007 -1.550  1.00 36.62  ? 873  LEU A CB  1 
ATOM   4650 C  CG  . LEU A 1 610 ? -29.318 -62.690 -0.771  1.00 38.32  ? 873  LEU A CG  1 
ATOM   4651 C  CD1 . LEU A 1 610 ? -27.972 -62.126 -1.193  1.00 40.15  ? 873  LEU A CD1 1 
ATOM   4652 C  CD2 . LEU A 1 610 ? -29.509 -62.551 0.742   1.00 38.87  ? 873  LEU A CD2 1 
ATOM   4653 N  N   . ILE A 1 611 ? -32.976 -61.699 -3.427  1.00 31.38  ? 874  ILE A N   1 
ATOM   4654 C  CA  . ILE A 1 611 ? -33.958 -60.868 -4.166  1.00 34.48  ? 874  ILE A CA  1 
ATOM   4655 C  C   . ILE A 1 611 ? -35.366 -61.455 -3.970  1.00 38.99  ? 874  ILE A C   1 
ATOM   4656 O  O   . ILE A 1 611 ? -36.307 -60.667 -3.753  1.00 45.20  ? 874  ILE A O   1 
ATOM   4657 C  CB  . ILE A 1 611 ? -33.558 -60.751 -5.650  1.00 33.99  ? 874  ILE A CB  1 
ATOM   4658 C  CG1 . ILE A 1 611 ? -32.230 -59.985 -5.782  1.00 35.98  ? 874  ILE A CG1 1 
ATOM   4659 C  CG2 . ILE A 1 611 ? -34.678 -60.075 -6.415  1.00 34.48  ? 874  ILE A CG2 1 
ATOM   4660 C  CD1 . ILE A 1 611 ? -31.683 -59.820 -7.192  1.00 34.56  ? 874  ILE A CD1 1 
ATOM   4661 N  N   . GLY A 1 612 ? -35.491 -62.780 -3.995  1.00 33.40  ? 875  GLY A N   1 
ATOM   4662 C  CA  . GLY A 1 612 ? -36.750 -63.496 -3.725  1.00 40.70  ? 875  GLY A CA  1 
ATOM   4663 C  C   . GLY A 1 612 ? -37.364 -64.148 -4.959  1.00 40.60  ? 875  GLY A C   1 
ATOM   4664 O  O   . GLY A 1 612 ? -36.682 -64.408 -5.970  1.00 36.69  ? 875  GLY A O   1 
ATOM   4665 N  N   . ASN A 1 613 ? -38.659 -64.401 -4.876  1.00 49.40  ? 876  ASN A N   1 
ATOM   4666 C  CA  . ASN A 1 613 ? -39.396 -65.298 -5.797  1.00 48.95  ? 876  ASN A CA  1 
ATOM   4667 C  C   . ASN A 1 613 ? -39.900 -64.436 -6.961  1.00 44.47  ? 876  ASN A C   1 
ATOM   4668 O  O   . ASN A 1 613 ? -40.965 -63.849 -6.842  1.00 61.81  ? 876  ASN A O   1 
ATOM   4669 C  CB  . ASN A 1 613 ? -40.469 -66.062 -5.016  1.00 55.72  ? 876  ASN A CB  1 
ATOM   4670 C  CG  . ASN A 1 613 ? -41.160 -67.115 -5.856  1.00 63.39  ? 876  ASN A CG  1 
ATOM   4671 O  OD1 . ASN A 1 613 ? -40.677 -67.476 -6.924  1.00 72.07  ? 876  ASN A OD1 1 
ATOM   4672 N  ND2 . ASN A 1 613 ? -42.284 -67.626 -5.374  1.00 64.93  ? 876  ASN A ND2 1 
ATOM   4673 N  N   . GLU A 1 614 ? -39.121 -64.380 -8.033  1.00 37.96  ? 877  GLU A N   1 
ATOM   4674 C  CA  . GLU A 1 614 ? -39.249 -63.457 -9.171  1.00 34.95  ? 877  GLU A CA  1 
ATOM   4675 C  C   . GLU A 1 614 ? -39.067 -64.298 -10.431 1.00 34.15  ? 877  GLU A C   1 
ATOM   4676 O  O   . GLU A 1 614 ? -38.744 -65.478 -10.295 1.00 34.07  ? 877  GLU A O   1 
ATOM   4677 C  CB  . GLU A 1 614 ? -38.204 -62.351 -9.108  1.00 35.63  ? 877  GLU A CB  1 
ATOM   4678 C  CG  . GLU A 1 614 ? -38.314 -61.458 -7.902  1.00 37.14  ? 877  GLU A CG  1 
ATOM   4679 C  CD  . GLU A 1 614 ? -39.423 -60.413 -7.885  1.00 37.41  ? 877  GLU A CD  1 
ATOM   4680 O  OE1 . GLU A 1 614 ? -40.064 -60.176 -8.933  1.00 33.96  ? 877  GLU A OE1 1 
ATOM   4681 O  OE2 . GLU A 1 614 ? -39.603 -59.796 -6.808  1.00 35.00  ? 877  GLU A OE2 1 
ATOM   4682 N  N   . GLU A 1 615 ? -39.318 -63.719 -11.593 1.00 40.00  ? 878  GLU A N   1 
ATOM   4683 C  CA  . GLU A 1 615 ? -39.125 -64.418 -12.885 1.00 48.48  ? 878  GLU A CA  1 
ATOM   4684 C  C   . GLU A 1 615 ? -37.686 -64.114 -13.318 1.00 47.59  ? 878  GLU A C   1 
ATOM   4685 O  O   . GLU A 1 615 ? -37.400 -62.938 -13.602 1.00 44.40  ? 878  GLU A O   1 
ATOM   4686 C  CB  . GLU A 1 615 ? -40.150 -63.988 -13.950 1.00 53.26  ? 878  GLU A CB  1 
ATOM   4687 C  CG  . GLU A 1 615 ? -40.032 -64.821 -15.238 1.00 65.70  ? 878  GLU A CG  1 
ATOM   4688 C  CD  . GLU A 1 615 ? -40.757 -64.331 -16.495 1.00 76.67  ? 878  GLU A CD  1 
ATOM   4689 O  OE1 . GLU A 1 615 ? -41.651 -63.463 -16.388 1.00 74.42  ? 878  GLU A OE1 1 
ATOM   4690 O  OE2 . GLU A 1 615 ? -40.428 -64.825 -17.601 1.00 85.73  ? 878  GLU A OE2 1 
ATOM   4691 N  N   . TYR A 1 616 ? -36.852 -65.153 -13.330 1.00 44.78  ? 879  TYR A N   1 
ATOM   4692 C  CA  . TYR A 1 616 ? -35.427 -65.182 -13.747 1.00 46.20  ? 879  TYR A CA  1 
ATOM   4693 C  C   . TYR A 1 616 ? -35.273 -66.011 -15.033 1.00 47.26  ? 879  TYR A C   1 
ATOM   4694 O  O   . TYR A 1 616 ? -36.054 -66.937 -15.219 1.00 44.65  ? 879  TYR A O   1 
ATOM   4695 C  CB  . TYR A 1 616 ? -34.577 -65.814 -12.638 1.00 39.38  ? 879  TYR A CB  1 
ATOM   4696 C  CG  . TYR A 1 616 ? -34.670 -65.140 -11.292 1.00 36.54  ? 879  TYR A CG  1 
ATOM   4697 C  CD1 . TYR A 1 616 ? -33.901 -64.030 -11.008 1.00 35.85  ? 879  TYR A CD1 1 
ATOM   4698 C  CD2 . TYR A 1 616 ? -35.434 -65.671 -10.271 1.00 32.07  ? 879  TYR A CD2 1 
ATOM   4699 C  CE1 . TYR A 1 616 ? -33.929 -63.429 -9.763  1.00 37.21  ? 879  TYR A CE1 1 
ATOM   4700 C  CE2 . TYR A 1 616 ? -35.467 -65.091 -9.020  1.00 31.86  ? 879  TYR A CE2 1 
ATOM   4701 C  CZ  . TYR A 1 616 ? -34.733 -63.948 -8.767  1.00 35.42  ? 879  TYR A CZ  1 
ATOM   4702 O  OH  . TYR A 1 616 ? -34.748 -63.322 -7.541  1.00 39.36  ? 879  TYR A OH  1 
ATOM   4703 N  N   . THR A 1 617 ? -34.263 -65.699 -15.855 1.00 46.28  ? 880  THR A N   1 
ATOM   4704 C  CA  . THR A 1 617 ? -33.770 -66.501 -17.010 1.00 44.61  ? 880  THR A CA  1 
ATOM   4705 C  C   . THR A 1 617 ? -32.327 -67.003 -16.760 1.00 48.84  ? 880  THR A C   1 
ATOM   4706 O  O   . THR A 1 617 ? -31.498 -66.237 -16.210 1.00 41.82  ? 880  THR A O   1 
ATOM   4707 C  CB  . THR A 1 617 ? -33.748 -65.630 -18.266 1.00 53.76  ? 880  THR A CB  1 
ATOM   4708 O  OG1 . THR A 1 617 ? -35.003 -64.946 -18.277 1.00 50.48  ? 880  THR A OG1 1 
ATOM   4709 C  CG2 . THR A 1 617 ? -33.471 -66.416 -19.535 1.00 49.57  ? 880  THR A CG2 1 
ATOM   4710 N  N   . ASP A 1 618 ? -32.003 -68.228 -17.184 1.00 42.96  ? 881  ASP A N   1 
ATOM   4711 C  CA  . ASP A 1 618 ? -30.623 -68.756 -17.117 1.00 48.16  ? 881  ASP A CA  1 
ATOM   4712 C  C   . ASP A 1 618 ? -29.919 -68.410 -18.438 1.00 48.48  ? 881  ASP A C   1 
ATOM   4713 O  O   . ASP A 1 618 ? -30.309 -68.966 -19.454 1.00 39.44  ? 881  ASP A O   1 
ATOM   4714 C  CB  . ASP A 1 618 ? -30.645 -70.252 -16.827 1.00 51.81  ? 881  ASP A CB  1 
ATOM   4715 C  CG  . ASP A 1 618 ? -29.275 -70.916 -16.797 1.00 60.93  ? 881  ASP A CG  1 
ATOM   4716 O  OD1 . ASP A 1 618 ? -28.222 -70.201 -16.533 1.00 52.42  ? 881  ASP A OD1 1 
ATOM   4717 O  OD2 . ASP A 1 618 ? -29.271 -72.157 -17.026 1.00 60.81  ? 881  ASP A OD2 1 
ATOM   4718 N  N   . TYR A 1 619 ? -28.908 -67.529 -18.406 1.00 47.28  ? 882  TYR A N   1 
ATOM   4719 C  CA  . TYR A 1 619 ? -28.133 -67.086 -19.587 1.00 39.37  ? 882  TYR A CA  1 
ATOM   4720 C  C   . TYR A 1 619 ? -26.826 -67.880 -19.718 1.00 38.99  ? 882  TYR A C   1 
ATOM   4721 O  O   . TYR A 1 619 ? -26.176 -67.751 -20.769 1.00 42.77  ? 882  TYR A O   1 
ATOM   4722 C  CB  . TYR A 1 619 ? -27.883 -65.585 -19.482 1.00 39.27  ? 882  TYR A CB  1 
ATOM   4723 C  CG  . TYR A 1 619 ? -29.100 -64.725 -19.672 1.00 41.02  ? 882  TYR A CG  1 
ATOM   4724 C  CD1 . TYR A 1 619 ? -29.642 -64.531 -20.934 1.00 41.83  ? 882  TYR A CD1 1 
ATOM   4725 C  CD2 . TYR A 1 619 ? -29.715 -64.114 -18.588 1.00 41.04  ? 882  TYR A CD2 1 
ATOM   4726 C  CE1 . TYR A 1 619 ? -30.756 -63.720 -21.119 1.00 44.88  ? 882  TYR A CE1 1 
ATOM   4727 C  CE2 . TYR A 1 619 ? -30.832 -63.308 -18.750 1.00 43.94  ? 882  TYR A CE2 1 
ATOM   4728 C  CZ  . TYR A 1 619 ? -31.349 -63.101 -20.023 1.00 45.17  ? 882  TYR A CZ  1 
ATOM   4729 O  OH  . TYR A 1 619 ? -32.431 -62.281 -20.183 1.00 40.27  ? 882  TYR A OH  1 
ATOM   4730 N  N   . MET A 1 620 ? -26.460 -68.709 -18.739 1.00 39.20  ? 883  MET A N   1 
ATOM   4731 C  CA  . MET A 1 620 ? -25.166 -69.470 -18.748 1.00 41.34  ? 883  MET A CA  1 
ATOM   4732 C  C   . MET A 1 620 ? -25.054 -70.445 -19.937 1.00 42.40  ? 883  MET A C   1 
ATOM   4733 O  O   . MET A 1 620 ? -23.977 -70.533 -20.528 1.00 50.52  ? 883  MET A O   1 
ATOM   4734 C  CB  . MET A 1 620 ? -24.903 -70.181 -17.415 1.00 36.17  ? 883  MET A CB  1 
ATOM   4735 C  CG  . MET A 1 620 ? -25.018 -69.243 -16.158 1.00 39.09  ? 883  MET A CG  1 
ATOM   4736 S  SD  . MET A 1 620 ? -24.208 -67.605 -16.319 1.00 40.68  ? 883  MET A SD  1 
ATOM   4737 C  CE  . MET A 1 620 ? -22.520 -68.159 -16.576 1.00 38.69  ? 883  MET A CE  1 
ATOM   4738 N  N   . PRO A 1 621 ? -26.113 -71.168 -20.389 1.00 47.48  ? 884  PRO A N   1 
ATOM   4739 C  CA  . PRO A 1 621 ? -26.029 -71.985 -21.608 1.00 47.25  ? 884  PRO A CA  1 
ATOM   4740 C  C   . PRO A 1 621 ? -25.715 -71.309 -22.953 1.00 50.10  ? 884  PRO A C   1 
ATOM   4741 O  O   . PRO A 1 621 ? -25.474 -71.993 -23.914 1.00 58.33  ? 884  PRO A O   1 
ATOM   4742 C  CB  . PRO A 1 621 ? -27.406 -72.673 -21.678 1.00 51.73  ? 884  PRO A CB  1 
ATOM   4743 C  CG  . PRO A 1 621 ? -27.838 -72.757 -20.218 1.00 48.63  ? 884  PRO A CG  1 
ATOM   4744 C  CD  . PRO A 1 621 ? -27.357 -71.438 -19.645 1.00 49.57  ? 884  PRO A CD  1 
ATOM   4745 N  N   . SER A 1 622 ? -25.718 -69.975 -22.988 0.48 51.25  ? 885  SER A N   1 
ATOM   4746 C  CA  . SER A 1 622 ? -25.217 -69.168 -24.132 0.48 52.49  ? 885  SER A CA  1 
ATOM   4747 C  C   . SER A 1 622 ? -23.699 -69.368 -24.285 0.48 53.29  ? 885  SER A C   1 
ATOM   4748 O  O   . SER A 1 622 ? -23.174 -69.083 -25.387 0.48 51.72  ? 885  SER A O   1 
ATOM   4749 C  CB  . SER A 1 622 ? -25.580 -67.707 -23.979 0.48 52.10  ? 885  SER A CB  1 
ATOM   4750 O  OG  . SER A 1 622 ? -24.823 -67.091 -22.947 0.48 50.53  ? 885  SER A OG  1 
ATOM   4751 N  N   . MET A 1 623 ? -23.025 -69.846 -23.228 1.00 49.01  ? 886  MET A N   1 
ATOM   4752 C  CA  . MET A 1 623 ? -21.573 -70.177 -23.267 1.00 54.91  ? 886  MET A CA  1 
ATOM   4753 C  C   . MET A 1 623 ? -21.393 -71.680 -23.513 1.00 56.47  ? 886  MET A C   1 
ATOM   4754 O  O   . MET A 1 623 ? -22.132 -72.454 -22.896 1.00 61.58  ? 886  MET A O   1 
ATOM   4755 C  CB  . MET A 1 623 ? -20.901 -69.794 -21.945 1.00 57.57  ? 886  MET A CB  1 
ATOM   4756 C  CG  . MET A 1 623 ? -21.412 -68.495 -21.392 1.00 59.59  ? 886  MET A CG  1 
ATOM   4757 S  SD  . MET A 1 623 ? -20.453 -67.919 -19.994 1.00 55.69  ? 886  MET A SD  1 
ATOM   4758 C  CE  . MET A 1 623 ? -19.057 -67.251 -20.890 1.00 48.94  ? 886  MET A CE  1 
ATOM   4759 N  N   . LYS A 1 624 ? -20.409 -72.076 -24.327 1.00 62.68  ? 887  LYS A N   1 
ATOM   4760 C  CA  . LYS A 1 624 ? -20.142 -73.503 -24.662 1.00 70.26  ? 887  LYS A CA  1 
ATOM   4761 C  C   . LYS A 1 624 ? -20.012 -74.341 -23.379 1.00 67.31  ? 887  LYS A C   1 
ATOM   4762 O  O   . LYS A 1 624 ? -20.664 -75.410 -23.306 1.00 64.47  ? 887  LYS A O   1 
ATOM   4763 C  CB  . LYS A 1 624 ? -18.896 -73.649 -25.547 1.00 74.88  ? 887  LYS A CB  1 
ATOM   4764 C  CG  . LYS A 1 624 ? -18.529 -75.087 -25.905 1.00 83.21  ? 887  LYS A CG  1 
ATOM   4765 C  CD  . LYS A 1 624 ? -17.795 -75.259 -27.237 1.00 96.14  ? 887  LYS A CD  1 
ATOM   4766 C  CE  . LYS A 1 624 ? -16.288 -75.413 -27.121 1.00 100.71 ? 887  LYS A CE  1 
ATOM   4767 N  NZ  . LYS A 1 624 ? -15.605 -74.123 -26.855 1.00 104.88 ? 887  LYS A NZ  1 
ATOM   4768 N  N   . ARG A 1 625 ? -19.235 -73.887 -22.389 1.00 63.37  ? 888  ARG A N   1 
ATOM   4769 C  CA  . ARG A 1 625 ? -18.813 -74.744 -21.241 1.00 61.18  ? 888  ARG A CA  1 
ATOM   4770 C  C   . ARG A 1 625 ? -20.010 -75.093 -20.350 1.00 62.05  ? 888  ARG A C   1 
ATOM   4771 O  O   . ARG A 1 625 ? -19.905 -76.076 -19.595 1.00 54.90  ? 888  ARG A O   1 
ATOM   4772 C  CB  . ARG A 1 625 ? -17.706 -74.072 -20.424 1.00 62.08  ? 888  ARG A CB  1 
ATOM   4773 C  CG  . ARG A 1 625 ? -18.146 -72.878 -19.591 1.00 61.48  ? 888  ARG A CG  1 
ATOM   4774 C  CD  . ARG A 1 625 ? -17.078 -72.486 -18.589 1.00 61.39  ? 888  ARG A CD  1 
ATOM   4775 N  NE  . ARG A 1 625 ? -17.032 -73.359 -17.422 1.00 61.57  ? 888  ARG A NE  1 
ATOM   4776 C  CZ  . ARG A 1 625 ? -15.966 -73.549 -16.628 1.00 67.18  ? 888  ARG A CZ  1 
ATOM   4777 N  NH1 . ARG A 1 625 ? -14.787 -72.974 -16.882 1.00 66.92  ? 888  ARG A NH1 1 
ATOM   4778 N  NH2 . ARG A 1 625 ? -16.095 -74.356 -15.586 1.00 56.98  ? 888  ARG A NH2 1 
ATOM   4779 N  N   . PHE A 1 626 ? -21.083 -74.294 -20.409 1.00 62.34  ? 889  PHE A N   1 
ATOM   4780 C  CA  . PHE A 1 626 ? -22.334 -74.475 -19.628 1.00 64.45  ? 889  PHE A CA  1 
ATOM   4781 C  C   . PHE A 1 626 ? -23.430 -75.074 -20.514 1.00 77.51  ? 889  PHE A C   1 
ATOM   4782 O  O   . PHE A 1 626 ? -24.484 -75.514 -19.980 1.00 77.45  ? 889  PHE A O   1 
ATOM   4783 C  CB  . PHE A 1 626 ? -22.777 -73.137 -19.042 1.00 58.53  ? 889  PHE A CB  1 
ATOM   4784 C  CG  . PHE A 1 626 ? -21.762 -72.538 -18.111 1.00 56.12  ? 889  PHE A CG  1 
ATOM   4785 C  CD1 . PHE A 1 626 ? -21.386 -73.211 -16.955 1.00 57.42  ? 889  PHE A CD1 1 
ATOM   4786 C  CD2 . PHE A 1 626 ? -21.163 -71.319 -18.407 1.00 55.78  ? 889  PHE A CD2 1 
ATOM   4787 C  CE1 . PHE A 1 626 ? -20.434 -72.669 -16.098 1.00 62.62  ? 889  PHE A CE1 1 
ATOM   4788 C  CE2 . PHE A 1 626 ? -20.221 -70.772 -17.549 1.00 59.28  ? 889  PHE A CE2 1 
ATOM   4789 C  CZ  . PHE A 1 626 ? -19.860 -71.444 -16.390 1.00 62.38  ? 889  PHE A CZ  1 
ATOM   4790 N  N   . ARG A 1 627 ? -23.209 -75.068 -21.829 1.00 89.48  ? 890  ARG A N   1 
ATOM   4791 C  CA  . ARG A 1 627 ? -24.100 -75.735 -22.811 1.00 113.09 ? 890  ARG A CA  1 
ATOM   4792 C  C   . ARG A 1 627 ? -23.932 -77.250 -22.598 1.00 127.07 ? 890  ARG A C   1 
ATOM   4793 O  O   . ARG A 1 627 ? -23.371 -77.920 -23.494 1.00 153.04 ? 890  ARG A O   1 
ATOM   4794 C  CB  . ARG A 1 627 ? -23.771 -75.214 -24.219 1.00 109.66 ? 890  ARG A CB  1 
ATOM   4795 C  CG  . ARG A 1 627 ? -24.901 -75.346 -25.231 1.00 103.39 ? 890  ARG A CG  1 
ATOM   4796 C  CD  . ARG A 1 627 ? -24.620 -74.550 -26.493 1.00 97.78  ? 890  ARG A CD  1 
ATOM   4797 N  NE  . ARG A 1 627 ? -23.211 -74.611 -26.857 1.00 101.04 ? 890  ARG A NE  1 
ATOM   4798 C  CZ  . ARG A 1 627 ? -22.592 -75.640 -27.442 1.00 93.77  ? 890  ARG A CZ  1 
ATOM   4799 N  NH1 . ARG A 1 627 ? -23.249 -76.742 -27.771 1.00 88.82  ? 890  ARG A NH1 1 
ATOM   4800 N  NH2 . ARG A 1 627 ? -21.297 -75.557 -27.701 1.00 90.94  ? 890  ARG A NH2 1 
ATOM   4801 N  N   . ARG A 1 628 ? -24.369 -77.749 -21.429 1.00 117.66 ? 891  ARG A N   1 
ATOM   4802 C  CA  . ARG A 1 628 ? -24.166 -79.144 -20.948 1.00 113.64 ? 891  ARG A CA  1 
ATOM   4803 C  C   . ARG A 1 628 ? -22.669 -79.483 -20.985 1.00 113.47 ? 891  ARG A C   1 
ATOM   4804 O  O   . ARG A 1 628 ? -22.195 -80.316 -21.761 1.00 105.67 ? 891  ARG A O   1 
ATOM   4805 C  CB  . ARG A 1 628 ? -25.026 -80.104 -21.781 1.00 110.66 ? 891  ARG A CB  1 
ATOM   4806 C  CG  . ARG A 1 628 ? -26.517 -79.813 -21.681 1.00 116.10 ? 891  ARG A CG  1 
ATOM   4807 C  CD  . ARG A 1 628 ? -27.022 -79.918 -20.254 1.00 121.04 ? 891  ARG A CD  1 
ATOM   4808 N  NE  . ARG A 1 628 ? -26.710 -81.227 -19.691 1.00 128.29 ? 891  ARG A NE  1 
ATOM   4809 C  CZ  . ARG A 1 628 ? -26.583 -81.509 -18.394 1.00 126.88 ? 891  ARG A CZ  1 
ATOM   4810 N  NH1 . ARG A 1 628 ? -26.725 -80.569 -17.473 1.00 127.54 ? 891  ARG A NH1 1 
ATOM   4811 N  NH2 . ARG A 1 628 ? -26.296 -82.744 -18.020 1.00 126.85 ? 891  ARG A NH2 1 
HETATM 4812 ZN ZN  . ZN  B 2 .   ? -6.541  -55.084 -23.578 1.00 29.96  2 1001 ZN  A ZN  1 
HETATM 4813 ZN ZN  . ZN  C 2 .   ? -26.118 -14.669 -12.534 1.00 60.15  2 1002 ZN  A ZN  1 
HETATM 4814 O  O1  A MES D 3 .   ? -28.601 -57.319 0.678   0.25 764.72 ? 1003 MES A O1  1 
HETATM 4815 O  O1  B MES D 3 .   ? -28.328 -56.982 0.602   0.25 44.37  ? 1003 MES A O1  1 
HETATM 4816 C  C2  A MES D 3 .   ? -27.895 -57.615 1.872   0.25 765.90 ? 1003 MES A C2  1 
HETATM 4817 C  C2  B MES D 3 .   ? -27.581 -57.647 1.609   0.25 41.74  ? 1003 MES A C2  1 
HETATM 4818 C  C3  A MES D 3 .   ? -26.460 -57.161 1.788   0.25 766.94 ? 1003 MES A C3  1 
HETATM 4819 C  C3  B MES D 3 .   ? -26.110 -57.640 1.285   0.25 41.49  ? 1003 MES A C3  1 
HETATM 4820 N  N4  A MES D 3 .   ? -25.778 -57.809 0.625   0.25 768.96 ? 1003 MES A N4  1 
HETATM 4821 N  N4  B MES D 3 .   ? -25.886 -58.309 -0.034  0.25 39.73  ? 1003 MES A N4  1 
HETATM 4822 C  C5  A MES D 3 .   ? -26.574 -57.562 -0.617  0.25 764.73 ? 1003 MES A C5  1 
HETATM 4823 C  C5  B MES D 3 .   ? -26.680 -57.589 -1.075  0.25 41.14  ? 1003 MES A C5  1 
HETATM 4824 C  C6  A MES D 3 .   ? -28.003 -57.999 -0.415  0.25 762.05 ? 1003 MES A C6  1 
HETATM 4825 C  C6  B MES D 3 .   ? -28.132 -57.584 -0.672  0.25 41.75  ? 1003 MES A C6  1 
HETATM 4826 C  C7  A MES D 3 .   ? -24.365 -57.325 0.481   0.25 777.39 ? 1003 MES A C7  1 
HETATM 4827 C  C7  B MES D 3 .   ? -24.432 -58.396 -0.394  0.25 36.49  ? 1003 MES A C7  1 
HETATM 4828 C  C8  A MES D 3 .   ? -23.453 -58.335 -0.187  0.25 791.63 ? 1003 MES A C8  1 
HETATM 4829 C  C8  B MES D 3 .   ? -23.555 -57.468 0.423   0.25 34.93  ? 1003 MES A C8  1 
HETATM 4830 S  S   A MES D 3 .   ? -21.734 -57.908 -0.005  0.25 808.53 ? 1003 MES A S   1 
HETATM 4831 S  S   B MES D 3 .   ? -21.832 -57.915 0.315   0.25 32.73  ? 1003 MES A S   1 
HETATM 4832 O  O1S A MES D 3 .   ? -21.198 -58.794 0.976   0.25 813.31 ? 1003 MES A O1S 1 
HETATM 4833 O  O1S B MES D 3 .   ? -21.791 -59.349 0.381   0.25 31.59  ? 1003 MES A O1S 1 
HETATM 4834 O  O2S A MES D 3 .   ? -21.148 -58.120 -1.314  0.25 795.81 ? 1003 MES A O2S 1 
HETATM 4835 O  O2S B MES D 3 .   ? -21.382 -57.431 -0.958  0.25 31.48  ? 1003 MES A O2S 1 
HETATM 4836 O  O3S A MES D 3 .   ? -21.701 -56.533 0.384   0.25 813.25 ? 1003 MES A O3S 1 
HETATM 4837 O  O3S B MES D 3 .   ? -21.202 -57.274 1.429   0.25 30.71  ? 1003 MES A O3S 1 
HETATM 4838 S  S   . DMS E 4 .   ? -26.956 -61.758 -21.155 1.00 69.39  ? 1004 DMS A S   1 
HETATM 4839 O  O   . DMS E 4 .   ? -26.864 -62.207 -22.602 1.00 70.06  ? 1004 DMS A O   1 
HETATM 4840 C  C1  . DMS E 4 .   ? -28.299 -60.611 -21.075 1.00 71.41  ? 1004 DMS A C1  1 
HETATM 4841 C  C2  . DMS E 4 .   ? -25.660 -60.553 -20.944 1.00 66.30  ? 1004 DMS A C2  1 
HETATM 4842 S  S   . DMS F 4 .   ? -16.139 -69.177 -28.838 1.00 126.29 ? 1005 DMS A S   1 
HETATM 4843 O  O   . DMS F 4 .   ? -16.574 -67.728 -28.971 1.00 77.89  ? 1005 DMS A O   1 
HETATM 4844 C  C1  . DMS F 4 .   ? -16.992 -69.866 -27.426 1.00 106.93 ? 1005 DMS A C1  1 
HETATM 4845 C  C2  . DMS F 4 .   ? -14.472 -69.171 -28.196 1.00 105.94 ? 1005 DMS A C2  1 
HETATM 4846 P  P   . PO4 G 5 .   ? -4.058  -39.367 -23.548 1.00 79.60  ? 1006 PO4 A P   1 
HETATM 4847 O  O1  . PO4 G 5 .   ? -2.650  -39.989 -23.052 1.00 48.13  ? 1006 PO4 A O1  1 
HETATM 4848 O  O2  . PO4 G 5 .   ? -3.876  -37.865 -24.082 1.00 43.95  ? 1006 PO4 A O2  1 
HETATM 4849 O  O3  . PO4 G 5 .   ? -4.724  -40.234 -24.713 1.00 48.68  ? 1006 PO4 A O3  1 
HETATM 4850 O  O4  . PO4 G 5 .   ? -4.962  -39.394 -22.346 1.00 58.89  ? 1006 PO4 A O4  1 
HETATM 4851 P  P   . PO4 H 5 .   ? -17.880 -9.404  -27.914 1.00 110.50 ? 1007 PO4 A P   1 
HETATM 4852 O  O1  . PO4 H 5 .   ? -17.896 -10.105 -26.535 1.00 77.00  ? 1007 PO4 A O1  1 
HETATM 4853 O  O2  . PO4 H 5 .   ? -16.413 -9.151  -28.330 1.00 91.88  ? 1007 PO4 A O2  1 
HETATM 4854 O  O3  . PO4 H 5 .   ? -18.579 -10.273 -28.979 1.00 83.60  ? 1007 PO4 A O3  1 
HETATM 4855 O  O4  . PO4 H 5 .   ? -18.632 -8.066  -27.798 1.00 85.09  ? 1007 PO4 A O4  1 
HETATM 4856 C  C1  . PEG I 6 .   ? -16.718 -43.015 -40.847 1.00 77.77  ? 1008 PEG A C1  1 
HETATM 4857 O  O1  . PEG I 6 .   ? -17.987 -43.538 -40.509 1.00 67.78  ? 1008 PEG A O1  1 
HETATM 4858 C  C2  . PEG I 6 .   ? -16.275 -43.454 -42.209 1.00 81.37  ? 1008 PEG A C2  1 
HETATM 4859 O  O2  . PEG I 6 .   ? -16.117 -44.870 -42.216 1.00 79.30  ? 1008 PEG A O2  1 
HETATM 4860 C  C3  . PEG I 6 .   ? -16.074 -45.422 -43.526 1.00 81.49  ? 1008 PEG A C3  1 
HETATM 4861 C  C4  . PEG I 6 .   ? -14.856 -46.267 -43.657 1.00 91.45  ? 1008 PEG A C4  1 
HETATM 4862 O  O4  . PEG I 6 .   ? -15.150 -47.542 -44.179 1.00 94.83  ? 1008 PEG A O4  1 
HETATM 4863 CL CL  . CL  J 7 .   ? 4.159   -48.606 -29.742 0.50 51.22  ? 1009 CL  A CL  1 
HETATM 4864 N  N1  . LQI K 8 .   ? -4.471  -71.323 -20.031 0.48 61.81  ? 1010 LQI A N1  1 
HETATM 4865 C  C4  . LQI K 8 .   ? -3.028  -71.537 -19.916 0.48 61.26  ? 1010 LQI A C4  1 
HETATM 4866 C  C5  . LQI K 8 .   ? -4.759  -70.339 -21.073 0.48 63.27  ? 1010 LQI A C5  1 
HETATM 4867 C  C6  . LQI K 8 .   ? -4.146  -69.004 -20.703 0.48 63.88  ? 1010 LQI A C6  1 
HETATM 4868 C  C7  . LQI K 8 .   ? -5.407  -71.947 -19.301 0.48 57.72  ? 1010 LQI A C7  1 
HETATM 4869 C  C8  . LQI K 8 .   ? -6.839  -71.605 -19.544 0.48 52.46  ? 1010 LQI A C8  1 
HETATM 4870 C  C10 . LQI K 8 .   ? -8.887  -71.072 -20.253 0.48 51.84  ? 1010 LQI A C10 1 
HETATM 4871 C  C13 . LQI K 8 .   ? -11.253 -70.927 -18.782 0.48 53.96  ? 1010 LQI A C13 1 
HETATM 4872 C  C15 . LQI K 8 .   ? -8.928  -71.359 -18.897 0.48 53.16  ? 1010 LQI A C15 1 
HETATM 4873 C  C1  . LQI K 8 .   ? -2.036  -67.794 -20.067 0.48 63.10  ? 1010 LQI A C1  1 
HETATM 4874 C  C2  . LQI K 8 .   ? -2.646  -69.114 -20.501 0.48 63.12  ? 1010 LQI A C2  1 
HETATM 4875 C  C3  . LQI K 8 .   ? -2.340  -70.237 -19.521 0.48 61.80  ? 1010 LQI A C3  1 
HETATM 4876 O  O1  . LQI K 8 .   ? -5.124  -72.775 -18.445 0.48 58.56  ? 1010 LQI A O1  1 
HETATM 4877 C  C9  . LQI K 8 .   ? -7.522  -71.246 -20.647 0.48 51.54  ? 1010 LQI A C9  1 
HETATM 4878 C  C11 . LQI K 8 .   ? -10.077 -70.694 -20.877 0.48 52.65  ? 1010 LQI A C11 1 
HETATM 4879 C  C12 . LQI K 8 .   ? -11.251 -70.623 -20.138 0.48 54.00  ? 1010 LQI A C12 1 
HETATM 4880 C  C14 . LQI K 8 .   ? -10.081 -71.301 -18.141 0.48 54.29  ? 1010 LQI A C14 1 
HETATM 4881 O  O2  . LQI K 8 .   ? -7.669  -71.688 -18.442 0.48 49.91  ? 1010 LQI A O2  1 
HETATM 4882 O  O   . HOH L 9 .   ? -14.856 -49.865 -32.047 0.40 68.26  ? 1101 HOH A O   1 
HETATM 4883 O  O   . HOH L 9 .   ? -7.660  -48.925 0.471   1.00 60.87  ? 1102 HOH A O   1 
HETATM 4884 O  O   . HOH L 9 .   ? -33.738 -47.251 -4.707  1.00 45.99  ? 1103 HOH A O   1 
HETATM 4885 O  O   . HOH L 9 .   ? -22.142 -52.988 -46.604 1.00 63.17  ? 1104 HOH A O   1 
HETATM 4886 O  O   . HOH L 9 .   ? -34.540 -20.885 -22.959 1.00 61.22  ? 1105 HOH A O   1 
HETATM 4887 O  O   . HOH L 9 .   ? 3.023   -51.025 -26.478 1.00 42.51  ? 1106 HOH A O   1 
HETATM 4888 O  O   . HOH L 9 .   ? -22.305 -42.201 0.010   1.00 76.18  ? 1107 HOH A O   1 
HETATM 4889 O  O   . HOH L 9 .   ? -22.297 -43.865 -32.108 1.00 56.81  ? 1108 HOH A O   1 
HETATM 4890 O  O   . HOH L 9 .   ? -32.639 -51.738 -27.102 1.00 47.00  ? 1109 HOH A O   1 
HETATM 4891 O  O   . HOH L 9 .   ? -22.936 -64.779 -38.842 1.00 57.85  ? 1110 HOH A O   1 
HETATM 4892 O  O   . HOH L 9 .   ? -5.747  -58.222 -36.883 1.00 55.94  ? 1111 HOH A O   1 
HETATM 4893 O  O   . HOH L 9 .   ? -4.092  -57.207 -9.932  1.00 41.58  ? 1112 HOH A O   1 
HETATM 4894 O  O   . HOH L 9 .   ? -4.232  -53.442 -27.755 1.00 39.58  ? 1113 HOH A O   1 
HETATM 4895 O  O   . HOH L 9 .   ? -13.718 -49.228 -30.079 1.00 47.65  ? 1114 HOH A O   1 
HETATM 4896 O  O   . HOH L 9 .   ? -24.267 -69.025 -27.631 1.00 47.81  ? 1115 HOH A O   1 
HETATM 4897 O  O   . HOH L 9 .   ? -4.701  -54.246 -11.812 1.00 50.27  ? 1116 HOH A O   1 
HETATM 4898 O  O   . HOH L 9 .   ? -22.505 -10.174 -8.819  1.00 53.51  ? 1117 HOH A O   1 
HETATM 4899 O  O   . HOH L 9 .   ? 0.077   -32.380 -27.323 1.00 33.34  ? 1118 HOH A O   1 
HETATM 4900 O  O   . HOH L 9 .   ? -28.904 -62.508 -25.185 1.00 48.16  ? 1119 HOH A O   1 
HETATM 4901 O  O   . HOH L 9 .   ? -28.064 -46.596 0.270   1.00 54.48  ? 1120 HOH A O   1 
HETATM 4902 O  O   . HOH L 9 .   ? -4.520  -65.373 -15.144 1.00 43.31  ? 1121 HOH A O   1 
HETATM 4903 O  O   . HOH L 9 .   ? -7.475  -42.204 -42.601 1.00 47.38  ? 1122 HOH A O   1 
HETATM 4904 O  O   . HOH L 9 .   ? -32.349 -60.212 -18.708 1.00 49.36  ? 1123 HOH A O   1 
HETATM 4905 O  O   . HOH L 9 .   ? -28.549 -68.117 -30.481 1.00 65.59  ? 1124 HOH A O   1 
HETATM 4906 O  O   . HOH L 9 .   ? -19.547 -27.104 -39.408 1.00 35.83  ? 1125 HOH A O   1 
HETATM 4907 O  O   . HOH L 9 .   ? -23.932 -45.941 -36.957 1.00 59.82  ? 1126 HOH A O   1 
HETATM 4908 O  O   . HOH L 9 .   ? -3.306  -19.984 -22.476 1.00 47.52  ? 1127 HOH A O   1 
HETATM 4909 O  O   . HOH L 9 .   ? -9.594  -64.325 -31.141 0.48 42.32  ? 1128 HOH A O   1 
HETATM 4910 O  O   . HOH L 9 .   ? -32.602 -70.859 -9.210  1.00 57.56  ? 1129 HOH A O   1 
HETATM 4911 O  O   . HOH L 9 .   ? 4.675   -36.212 -23.153 1.00 49.75  ? 1130 HOH A O   1 
HETATM 4912 O  O   . HOH L 9 .   ? -25.063 -14.097 -4.178  1.00 56.34  ? 1131 HOH A O   1 
HETATM 4913 O  O   . HOH L 9 .   ? -32.920 -63.153 -15.124 1.00 34.35  ? 1132 HOH A O   1 
HETATM 4914 O  O   . HOH L 9 .   ? -40.909 -57.571 -6.504  1.00 77.13  ? 1133 HOH A O   1 
HETATM 4915 O  O   . HOH L 9 .   ? 11.278  -34.278 -32.515 1.00 45.38  ? 1134 HOH A O   1 
HETATM 4916 O  O   . HOH L 9 .   ? 5.793   -44.301 -36.139 1.00 56.18  ? 1135 HOH A O   1 
HETATM 4917 O  O   . HOH L 9 .   ? 2.927   -39.060 -26.402 1.00 38.41  ? 1136 HOH A O   1 
HETATM 4918 O  O   . HOH L 9 .   ? -40.321 -60.952 -11.412 1.00 34.02  ? 1137 HOH A O   1 
HETATM 4919 O  O   . HOH L 9 .   ? -17.155 -34.533 -41.930 1.00 62.93  ? 1138 HOH A O   1 
HETATM 4920 O  O   . HOH L 9 .   ? -0.052  -31.015 -22.421 1.00 32.64  ? 1139 HOH A O   1 
HETATM 4921 O  O   . HOH L 9 .   ? -7.431  -47.215 -17.961 1.00 40.62  ? 1140 HOH A O   1 
HETATM 4922 O  O   . HOH L 9 .   ? -31.946 -57.106 -21.756 1.00 39.51  ? 1141 HOH A O   1 
HETATM 4923 O  O   . HOH L 9 .   ? -15.624 -21.927 -18.365 1.00 41.76  ? 1142 HOH A O   1 
HETATM 4924 O  O   . HOH L 9 .   ? -12.505 -57.907 0.000   0.50 26.26  ? 1143 HOH A O   1 
HETATM 4925 O  O   . HOH L 9 .   ? -31.850 -59.891 -15.766 1.00 34.85  ? 1144 HOH A O   1 
HETATM 4926 O  O   . HOH L 9 .   ? -39.135 -60.536 -4.328  1.00 41.04  ? 1145 HOH A O   1 
HETATM 4927 O  O   . HOH L 9 .   ? -3.862  -61.428 -15.295 1.00 41.72  ? 1146 HOH A O   1 
HETATM 4928 O  O   . HOH L 9 .   ? -29.531 -50.108 -27.590 1.00 53.29  ? 1147 HOH A O   1 
HETATM 4929 O  O   . HOH L 9 .   ? -29.180 -63.322 -34.604 1.00 66.09  ? 1148 HOH A O   1 
HETATM 4930 O  O   . HOH L 9 .   ? -0.648  -52.512 -35.501 1.00 49.50  ? 1149 HOH A O   1 
HETATM 4931 O  O   . HOH L 9 .   ? -26.785 -25.590 -32.880 1.00 44.16  ? 1150 HOH A O   1 
HETATM 4932 O  O   . HOH L 9 .   ? 5.374   -29.858 -21.151 1.00 42.19  ? 1151 HOH A O   1 
HETATM 4933 O  O   . HOH L 9 .   ? -29.270 -50.163 -30.260 1.00 51.19  ? 1152 HOH A O   1 
HETATM 4934 O  O   . HOH L 9 .   ? -19.220 -20.418 -40.003 1.00 52.45  ? 1153 HOH A O   1 
HETATM 4935 O  O   . HOH L 9 .   ? -38.512 -60.690 -14.467 1.00 49.84  ? 1154 HOH A O   1 
HETATM 4936 O  O   . HOH L 9 .   ? -19.008 -65.033 -7.135  1.00 25.72  ? 1155 HOH A O   1 
HETATM 4937 O  O   . HOH L 9 .   ? 4.186   -28.234 -43.564 1.00 47.59  ? 1156 HOH A O   1 
HETATM 4938 O  O   . HOH L 9 .   ? -39.944 -64.227 -2.544  1.00 58.45  ? 1157 HOH A O   1 
HETATM 4939 O  O   . HOH L 9 .   ? 1.675   -31.985 -38.456 1.00 36.87  ? 1158 HOH A O   1 
HETATM 4940 O  O   . HOH L 9 .   ? -14.757 -45.327 2.633   0.50 65.54  ? 1159 HOH A O   1 
HETATM 4941 O  O   . HOH L 9 .   ? -12.261 -36.523 -39.148 1.00 37.79  ? 1160 HOH A O   1 
HETATM 4942 O  O   . HOH L 9 .   ? -9.481  -21.265 -26.499 1.00 48.01  ? 1161 HOH A O   1 
HETATM 4943 O  O   . HOH L 9 .   ? -17.541 -41.734 -36.674 1.00 38.09  ? 1162 HOH A O   1 
HETATM 4944 O  O   . HOH L 9 .   ? 5.739   -32.390 -37.439 1.00 43.20  ? 1163 HOH A O   1 
HETATM 4945 O  O   . HOH L 9 .   ? -8.631  -64.686 -6.867  1.00 37.52  ? 1164 HOH A O   1 
HETATM 4946 O  O   . HOH L 9 .   ? -34.795 -62.564 0.646   1.00 30.49  ? 1165 HOH A O   1 
HETATM 4947 O  O   . HOH L 9 .   ? -18.179 -61.874 -3.043  1.00 32.50  ? 1166 HOH A O   1 
HETATM 4948 O  O   . HOH L 9 .   ? -16.183 -66.685 -20.711 1.00 50.16  ? 1167 HOH A O   1 
HETATM 4949 O  O   . HOH L 9 .   ? -38.120 -67.101 -8.222  1.00 53.17  ? 1168 HOH A O   1 
HETATM 4950 O  O   . HOH L 9 .   ? -17.960 -65.304 -36.268 1.00 56.24  ? 1169 HOH A O   1 
HETATM 4951 O  O   . HOH L 9 .   ? -29.457 -33.885 -28.428 1.00 64.02  ? 1170 HOH A O   1 
HETATM 4952 O  O   . HOH L 9 .   ? -22.974 -27.404 -24.176 1.00 43.19  ? 1171 HOH A O   1 
HETATM 4953 O  O   . HOH L 9 .   ? -4.280  -22.803 -24.644 1.00 43.46  ? 1172 HOH A O   1 
HETATM 4954 O  O   . HOH L 9 .   ? -39.574 -55.009 -6.358  1.00 49.58  ? 1173 HOH A O   1 
HETATM 4955 O  O   . HOH L 9 .   ? -14.930 -63.811 -0.495  1.00 31.80  ? 1174 HOH A O   1 
HETATM 4956 O  O   . HOH L 9 .   ? -10.732 -47.961 -38.932 1.00 32.86  ? 1175 HOH A O   1 
HETATM 4957 O  O   . HOH L 9 .   ? -20.707 -29.429 -24.605 1.00 44.00  ? 1176 HOH A O   1 
HETATM 4958 O  O   . HOH L 9 .   ? -26.478 -71.056 -3.431  1.00 46.96  ? 1177 HOH A O   1 
HETATM 4959 O  O   . HOH L 9 .   ? -3.212  -54.942 -17.907 1.00 33.11  ? 1178 HOH A O   1 
HETATM 4960 O  O   . HOH L 9 .   ? -35.860 -66.196 -0.664  1.00 42.22  ? 1179 HOH A O   1 
HETATM 4961 O  O   . HOH L 9 .   ? -19.214 -69.522 -8.227  1.00 30.00  ? 1180 HOH A O   1 
HETATM 4962 O  O   . HOH L 9 .   ? 7.992   -42.610 -35.878 1.00 46.83  ? 1181 HOH A O   1 
HETATM 4963 O  O   . HOH L 9 .   ? -15.474 -65.569 -33.693 1.00 57.20  ? 1182 HOH A O   1 
HETATM 4964 O  O   . HOH L 9 .   ? -5.528  -59.992 -0.634  1.00 42.46  ? 1183 HOH A O   1 
HETATM 4965 O  O   . HOH L 9 .   ? -9.205  -58.935 -13.226 1.00 30.72  ? 1184 HOH A O   1 
HETATM 4966 O  O   . HOH L 9 .   ? -22.132 -29.873 -13.537 1.00 64.05  ? 1185 HOH A O   1 
HETATM 4967 O  O   . HOH L 9 .   ? 5.672   -38.354 -23.973 1.00 56.83  ? 1186 HOH A O   1 
HETATM 4968 O  O   . HOH L 9 .   ? -14.841 -70.626 -18.281 0.48 25.13  ? 1187 HOH A O   1 
HETATM 4969 O  O   . HOH L 9 .   ? -11.000 -62.171 -18.776 1.00 26.48  ? 1188 HOH A O   1 
HETATM 4970 O  O   . HOH L 9 .   ? -17.086 -51.715 -15.376 1.00 26.14  ? 1189 HOH A O   1 
HETATM 4971 O  O   . HOH L 9 .   ? -22.343 -73.991 -11.551 1.00 37.32  ? 1190 HOH A O   1 
HETATM 4972 O  O   . HOH L 9 .   ? -22.644 -65.662 -23.801 1.00 45.44  ? 1191 HOH A O   1 
HETATM 4973 O  O   . HOH L 9 .   ? -12.641 -42.227 -38.759 1.00 42.76  ? 1192 HOH A O   1 
HETATM 4974 O  O   . HOH L 9 .   ? -17.820 -71.535 -22.502 1.00 51.21  ? 1193 HOH A O   1 
HETATM 4975 O  O   . HOH L 9 .   ? 5.987   -31.129 -18.950 1.00 49.37  ? 1194 HOH A O   1 
HETATM 4976 O  O   . HOH L 9 .   ? -8.919  -25.909 -43.948 1.00 46.13  ? 1195 HOH A O   1 
HETATM 4977 O  O   . HOH L 9 .   ? -21.286 -46.693 -10.389 1.00 57.68  ? 1196 HOH A O   1 
HETATM 4978 O  O   . HOH L 9 .   ? -13.699 -74.163 -14.044 1.00 49.00  ? 1197 HOH A O   1 
HETATM 4979 O  O   . HOH L 9 .   ? -5.007  -48.491 -28.402 1.00 33.38  ? 1198 HOH A O   1 
HETATM 4980 O  O   . HOH L 9 .   ? -8.982  -70.809 -14.395 1.00 46.03  ? 1199 HOH A O   1 
HETATM 4981 O  O   . HOH L 9 .   ? 7.538   -21.883 -23.722 1.00 46.98  ? 1200 HOH A O   1 
HETATM 4982 O  O   . HOH L 9 .   ? 4.033   -26.259 -28.854 1.00 41.66  ? 1201 HOH A O   1 
HETATM 4983 O  O   . HOH L 9 .   ? -8.544  -16.631 -38.444 1.00 51.29  ? 1202 HOH A O   1 
HETATM 4984 O  O   . HOH L 9 .   ? -4.333  -56.772 -13.093 1.00 54.74  ? 1203 HOH A O   1 
HETATM 4985 O  O   . HOH L 9 .   ? -29.241 -17.813 -20.026 1.00 50.22  ? 1204 HOH A O   1 
HETATM 4986 O  O   . HOH L 9 .   ? -26.571 -20.673 -38.451 1.00 55.25  ? 1205 HOH A O   1 
HETATM 4987 O  O   . HOH L 9 .   ? -18.210 -69.081 -24.658 1.00 42.37  ? 1206 HOH A O   1 
HETATM 4988 O  O   . HOH L 9 .   ? -0.473  -35.528 -27.561 1.00 43.84  ? 1207 HOH A O   1 
HETATM 4989 O  O   . HOH L 9 .   ? -37.199 -50.251 -5.360  1.00 42.92  ? 1208 HOH A O   1 
HETATM 4990 O  O   . HOH L 9 .   ? -13.337 -68.258 -6.079  1.00 44.57  ? 1209 HOH A O   1 
HETATM 4991 O  O   . HOH L 9 .   ? -22.807 -37.204 -37.172 1.00 65.28  ? 1210 HOH A O   1 
HETATM 4992 O  O   . HOH L 9 .   ? -5.845  -48.941 -21.118 1.00 38.55  ? 1211 HOH A O   1 
HETATM 4993 O  O   . HOH L 9 .   ? -27.930 -18.231 -34.330 1.00 54.46  ? 1212 HOH A O   1 
HETATM 4994 O  O   . HOH L 9 .   ? -15.410 -54.630 -43.234 1.00 49.05  ? 1213 HOH A O   1 
HETATM 4995 O  O   . HOH L 9 .   ? -15.047 -34.657 -28.647 1.00 31.71  ? 1214 HOH A O   1 
HETATM 4996 O  O   . HOH L 9 .   ? -22.663 -27.680 -18.492 1.00 62.26  ? 1215 HOH A O   1 
HETATM 4997 O  O   . HOH L 9 .   ? -20.107 -75.756 -14.372 1.00 51.78  ? 1216 HOH A O   1 
HETATM 4998 O  O   . HOH L 9 .   ? -35.901 -58.957 -20.697 1.00 61.51  ? 1217 HOH A O   1 
HETATM 4999 O  O   . HOH L 9 .   ? 3.706   -36.893 -43.814 1.00 55.36  ? 1218 HOH A O   1 
HETATM 5000 O  O   . HOH L 9 .   ? -22.642 -50.798 -9.127  1.00 36.84  ? 1219 HOH A O   1 
HETATM 5001 O  O   . HOH L 9 .   ? 8.681   -40.063 -31.374 1.00 55.35  ? 1220 HOH A O   1 
HETATM 5002 O  O   . HOH L 9 .   ? -25.365 -53.370 -2.007  1.00 34.35  ? 1221 HOH A O   1 
HETATM 5003 O  O   . HOH L 9 .   ? -23.048 -20.687 -37.081 1.00 45.07  ? 1222 HOH A O   1 
HETATM 5004 O  O   . HOH L 9 .   ? -21.894 -31.370 -39.284 1.00 53.61  ? 1223 HOH A O   1 
HETATM 5005 O  O   . HOH L 9 .   ? -19.921 -37.929 -36.399 1.00 40.15  ? 1224 HOH A O   1 
HETATM 5006 O  O   . HOH L 9 .   ? -30.075 -56.687 -34.548 1.00 45.68  ? 1225 HOH A O   1 
HETATM 5007 O  O   . HOH L 9 .   ? -27.960 -23.185 -25.965 1.00 34.48  ? 1226 HOH A O   1 
HETATM 5008 O  O   . HOH L 9 .   ? -26.231 -30.730 -22.944 1.00 58.78  ? 1227 HOH A O   1 
HETATM 5009 O  O   . HOH L 9 .   ? -20.798 -31.655 -28.926 1.00 32.03  ? 1228 HOH A O   1 
HETATM 5010 O  O   . HOH L 9 .   ? -34.391 -22.316 -29.616 0.50 34.33  ? 1229 HOH A O   1 
HETATM 5011 O  O   . HOH L 9 .   ? -14.933 -53.948 -4.196  1.00 30.08  ? 1230 HOH A O   1 
HETATM 5012 O  O   . HOH L 9 .   ? -29.873 -59.303 -19.673 1.00 40.43  ? 1231 HOH A O   1 
HETATM 5013 O  O   . HOH L 9 .   ? -28.481 -49.571 0.205   1.00 44.09  ? 1232 HOH A O   1 
HETATM 5014 O  O   . HOH L 9 .   ? -6.826  -60.791 -30.734 1.00 57.70  ? 1233 HOH A O   1 
HETATM 5015 O  O   . HOH L 9 .   ? -23.055 -33.442 -36.471 1.00 36.63  ? 1234 HOH A O   1 
HETATM 5016 O  O   . HOH L 9 .   ? -5.171  -15.132 -27.327 1.00 49.65  ? 1235 HOH A O   1 
HETATM 5017 O  O   . HOH L 9 .   ? -12.572 -43.641 -16.165 1.00 57.52  ? 1236 HOH A O   1 
HETATM 5018 O  O   . HOH L 9 .   ? 1.112   -21.245 -44.887 1.00 52.27  ? 1237 HOH A O   1 
HETATM 5019 O  O   . HOH L 9 .   ? -11.564 -41.054 -19.698 1.00 56.32  ? 1238 HOH A O   1 
HETATM 5020 O  O   . HOH L 9 .   ? -38.859 -54.574 -19.017 1.00 45.34  ? 1239 HOH A O   1 
HETATM 5021 O  O   . HOH L 9 .   ? -14.439 -56.160 -1.472  1.00 28.76  ? 1240 HOH A O   1 
HETATM 5022 O  O   . HOH L 9 .   ? -4.701  -62.102 -4.461  1.00 41.88  ? 1241 HOH A O   1 
HETATM 5023 O  O   . HOH L 9 .   ? -2.772  -41.870 -20.895 1.00 61.37  ? 1242 HOH A O   1 
HETATM 5024 O  O   . HOH L 9 .   ? -41.312 -57.907 -10.164 0.50 34.80  ? 1243 HOH A O   1 
HETATM 5025 O  O   . HOH L 9 .   ? -15.334 -36.422 -40.048 1.00 61.66  ? 1244 HOH A O   1 
HETATM 5026 O  O   . HOH L 9 .   ? -35.470 -49.934 -12.996 1.00 49.79  ? 1245 HOH A O   1 
HETATM 5027 O  O   . HOH L 9 .   ? -19.486 -17.194 -10.507 1.00 53.61  ? 1246 HOH A O   1 
HETATM 5028 O  O   . HOH L 9 .   ? -21.206 -41.199 -35.545 1.00 54.16  ? 1247 HOH A O   1 
HETATM 5029 O  O   . HOH L 9 .   ? -28.062 -16.825 -31.776 1.00 44.25  ? 1248 HOH A O   1 
HETATM 5030 O  O   . HOH L 9 .   ? -5.936  -50.079 -18.631 1.00 35.99  ? 1249 HOH A O   1 
HETATM 5031 O  O   . HOH L 9 .   ? 3.521   -30.985 -36.560 1.00 35.32  ? 1250 HOH A O   1 
HETATM 5032 O  O   . HOH L 9 .   ? -8.474  -27.059 -45.835 1.00 58.72  ? 1251 HOH A O   1 
HETATM 5033 O  O   . HOH L 9 .   ? -14.298 -51.945 -5.813  1.00 31.74  ? 1252 HOH A O   1 
HETATM 5034 O  O   . HOH L 9 .   ? -27.475 -15.702 -19.172 1.00 51.27  ? 1253 HOH A O   1 
HETATM 5035 O  O   . HOH L 9 .   ? -15.180 -48.471 -18.600 1.00 41.00  ? 1254 HOH A O   1 
HETATM 5036 O  O   . HOH L 9 .   ? -30.162 -60.589 -23.225 1.00 39.94  ? 1255 HOH A O   1 
HETATM 5037 O  O   . HOH L 9 .   ? -5.748  -59.018 -12.086 1.00 50.43  ? 1256 HOH A O   1 
HETATM 5038 O  O   . HOH L 9 .   ? -12.394 -66.744 -29.681 1.00 37.67  ? 1257 HOH A O   1 
HETATM 5039 O  O   . HOH L 9 .   ? -19.654 -64.245 -3.071  1.00 47.79  ? 1258 HOH A O   1 
HETATM 5040 O  O   . HOH L 9 .   ? -4.714  -56.178 -31.487 1.00 33.81  ? 1259 HOH A O   1 
HETATM 5041 O  O   . HOH L 9 .   ? 0.020   -54.802 -33.293 1.00 64.61  ? 1260 HOH A O   1 
HETATM 5042 O  O   . HOH L 9 .   ? -20.662 -67.172 -25.243 1.00 34.88  ? 1261 HOH A O   1 
HETATM 5043 O  O   . HOH L 9 .   ? -34.154 -69.849 -18.412 1.00 40.61  ? 1262 HOH A O   1 
HETATM 5044 O  O   . HOH L 9 .   ? 2.836   -64.209 -20.478 1.00 23.97  ? 1263 HOH A O   1 
HETATM 5045 O  O   . HOH L 9 .   ? -36.046 -54.110 -3.464  1.00 39.09  ? 1264 HOH A O   1 
HETATM 5046 O  O   . HOH L 9 .   ? 0.013   -47.745 -35.986 1.00 41.16  ? 1265 HOH A O   1 
HETATM 5047 O  O   . HOH L 9 .   ? 8.861   -23.603 -34.795 1.00 59.01  ? 1266 HOH A O   1 
HETATM 5048 O  O   . HOH L 9 .   ? -7.606  -29.483 -45.546 1.00 46.66  ? 1267 HOH A O   1 
HETATM 5049 O  O   . HOH L 9 .   ? -13.998 -53.355 -1.671  1.00 31.56  ? 1268 HOH A O   1 
HETATM 5050 O  O   . HOH L 9 .   ? -33.867 -46.869 -15.779 1.00 60.12  ? 1269 HOH A O   1 
HETATM 5051 O  O   . HOH L 9 .   ? -29.779 -61.429 -33.204 1.00 59.13  ? 1270 HOH A O   1 
HETATM 5052 O  O   . HOH L 9 .   ? -8.592  -30.733 -14.606 1.00 56.42  ? 1271 HOH A O   1 
HETATM 5053 O  O   . HOH L 9 .   ? -23.086 -49.137 -42.070 1.00 45.56  ? 1272 HOH A O   1 
HETATM 5054 O  O   . HOH L 9 .   ? -11.875 -71.747 -15.540 1.00 30.16  ? 1273 HOH A O   1 
HETATM 5055 O  O   . HOH L 9 .   ? -15.735 -26.503 -45.119 1.00 57.65  ? 1274 HOH A O   1 
HETATM 5056 O  O   . HOH L 9 .   ? 1.298   -37.829 -20.581 1.00 56.38  ? 1275 HOH A O   1 
HETATM 5057 O  O   . HOH L 9 .   ? -31.122 -45.031 -15.905 1.00 53.87  ? 1276 HOH A O   1 
HETATM 5058 O  O   . HOH L 9 .   ? -11.947 -73.956 -17.103 0.48 46.29  ? 1277 HOH A O   1 
HETATM 5059 O  O   . HOH L 9 .   ? -14.165 -11.168 -30.966 1.00 54.07  ? 1278 HOH A O   1 
HETATM 5060 O  O   . HOH L 9 .   ? -29.623 -35.774 -30.054 1.00 64.80  ? 1279 HOH A O   1 
HETATM 5061 O  O   . HOH L 9 .   ? -35.474 -58.818 -0.780  1.00 51.07  ? 1280 HOH A O   1 
HETATM 5062 O  O   . HOH L 9 .   ? -0.086  -45.483 -42.407 1.00 60.91  ? 1281 HOH A O   1 
HETATM 5063 O  O   . HOH L 9 .   ? -37.554 -52.254 -12.898 1.00 31.41  ? 1282 HOH A O   1 
HETATM 5064 O  O   . HOH L 9 .   ? -23.230 -75.053 -8.966  1.00 55.78  ? 1283 HOH A O   1 
HETATM 5065 O  O   . HOH L 9 .   ? -2.517  -57.804 -27.189 1.00 38.44  ? 1284 HOH A O   1 
HETATM 5066 O  O   . HOH L 9 .   ? -2.266  -39.271 -45.532 1.00 48.78  ? 1285 HOH A O   1 
HETATM 5067 O  O   . HOH L 9 .   ? -3.931  -70.746 -8.913  1.00 41.65  ? 1286 HOH A O   1 
HETATM 5068 O  O   . HOH L 9 .   ? -7.615  -61.689 -33.549 1.00 48.09  ? 1287 HOH A O   1 
HETATM 5069 O  O   . HOH L 9 .   ? -37.807 -68.029 -12.745 1.00 48.20  ? 1288 HOH A O   1 
HETATM 5070 O  O   . HOH L 9 .   ? -26.909 -50.947 -1.835  1.00 45.53  ? 1289 HOH A O   1 
HETATM 5071 O  O   . HOH L 9 .   ? -27.245 -26.757 -35.274 1.00 44.18  ? 1290 HOH A O   1 
HETATM 5072 O  O   . HOH L 9 .   ? -13.067 -32.556 -20.124 1.00 37.39  ? 1291 HOH A O   1 
HETATM 5073 O  O   . HOH L 9 .   ? -33.761 -57.179 -19.929 1.00 46.75  ? 1292 HOH A O   1 
HETATM 5074 O  O   . HOH L 9 .   ? -7.452  -57.496 -1.075  1.00 46.03  ? 1293 HOH A O   1 
HETATM 5075 O  O   . HOH L 9 .   ? -11.738 -39.723 -39.356 1.00 51.03  ? 1294 HOH A O   1 
HETATM 5076 O  O   . HOH L 9 .   ? -2.923  -57.814 -24.284 1.00 25.53  ? 1295 HOH A O   1 
HETATM 5077 O  O   . HOH L 9 .   ? -5.511  -68.398 -27.391 0.46 29.33  ? 1296 HOH A O   1 
HETATM 5078 O  O   . HOH L 9 .   ? 9.924   -37.781 -38.909 0.50 31.75  ? 1297 HOH A O   1 
HETATM 5079 O  O   . HOH L 9 .   ? -20.232 -45.979 -25.198 1.00 33.98  ? 1298 HOH A O   1 
HETATM 5080 O  O   . HOH L 9 .   ? 1.052   -30.720 -46.570 1.00 51.36  ? 1299 HOH A O   1 
HETATM 5081 O  O   . HOH L 9 .   ? -23.757 -45.096 -10.088 1.00 74.01  ? 1300 HOH A O   1 
HETATM 5082 O  O   . HOH L 9 .   ? -26.377 -27.224 -42.165 1.00 58.27  ? 1301 HOH A O   1 
HETATM 5083 O  O   . HOH L 9 .   ? 1.077   -70.309 -20.730 0.48 27.61  ? 1302 HOH A O   1 
HETATM 5084 O  O   . HOH L 9 .   ? -11.891 -69.852 -24.042 0.48 38.50  ? 1303 HOH A O   1 
HETATM 5085 O  O   . HOH L 9 .   ? -1.305  -69.310 -16.281 0.48 43.77  ? 1304 HOH A O   1 
HETATM 5086 O  O   . HOH L 9 .   ? -16.972 -57.065 -43.593 1.00 44.02  ? 1305 HOH A O   1 
HETATM 5087 O  O   . HOH L 9 .   ? -3.868  -56.352 -7.189  1.00 38.37  ? 1306 HOH A O   1 
HETATM 5088 O  O   . HOH L 9 .   ? -20.265 -31.265 -26.231 1.00 35.08  ? 1307 HOH A O   1 
HETATM 5089 O  O   . HOH L 9 .   ? -26.709 -67.484 -28.025 1.00 33.01  ? 1308 HOH A O   1 
HETATM 5090 O  O   . HOH L 9 .   ? -23.805 -57.886 -46.902 1.00 59.29  ? 1309 HOH A O   1 
HETATM 5091 O  O   . HOH L 9 .   ? 0.000   -57.907 -16.710 0.50 51.19  ? 1310 HOH A O   1 
HETATM 5092 O  O   . HOH L 9 .   ? -0.906  -32.211 -24.973 1.00 34.93  ? 1311 HOH A O   1 
HETATM 5093 O  O   . HOH L 9 .   ? 4.165   -68.873 -20.697 0.50 39.39  ? 1312 HOH A O   1 
HETATM 5094 O  O   . HOH L 9 .   ? -7.341  -29.710 -13.061 1.00 58.71  ? 1313 HOH A O   1 
HETATM 5095 O  O   . HOH L 9 .   ? -14.688 -56.697 -41.786 1.00 46.56  ? 1314 HOH A O   1 
HETATM 5096 O  O   . HOH L 9 .   ? -14.710 -20.895 -16.544 1.00 56.63  ? 1315 HOH A O   1 
HETATM 5097 O  O   . HOH L 9 .   ? -35.426 -67.436 -5.538  1.00 57.40  ? 1316 HOH A O   1 
HETATM 5098 O  O   . HOH L 9 .   ? 1.526   -41.860 -12.929 1.00 68.83  ? 1317 HOH A O   1 
HETATM 5099 O  O   . HOH L 9 .   ? -11.080 -46.006 3.887   1.00 53.24  ? 1318 HOH A O   1 
HETATM 5100 O  O   . HOH L 9 .   ? -3.340  -52.691 -38.240 1.00 69.67  ? 1319 HOH A O   1 
HETATM 5101 O  O   . HOH L 9 .   ? -14.985 -68.678 -19.792 1.00 51.28  ? 1320 HOH A O   1 
HETATM 5102 O  O   . HOH L 9 .   ? 4.365   -62.197 -19.898 1.00 30.94  ? 1321 HOH A O   1 
HETATM 5103 O  O   . HOH L 9 .   ? -6.066  -43.169 -20.265 1.00 59.04  ? 1322 HOH A O   1 
HETATM 5104 O  O   . HOH L 9 .   ? -2.698  -68.158 -14.249 0.48 44.96  ? 1323 HOH A O   1 
HETATM 5105 O  O   . HOH L 9 .   ? -34.699 -58.982 -28.993 1.00 63.92  ? 1324 HOH A O   1 
HETATM 5106 O  O   . HOH L 9 .   ? -3.069  -55.301 -28.840 1.00 38.99  ? 1325 HOH A O   1 
HETATM 5107 O  O   . HOH L 9 .   ? -8.864  -62.051 -41.248 1.00 69.52  ? 1326 HOH A O   1 
HETATM 5108 O  O   . HOH L 9 .   ? -5.873  -68.727 -7.135  1.00 47.45  ? 1327 HOH A O   1 
HETATM 5109 O  O   . HOH L 9 .   ? 3.250   -33.839 -13.519 1.00 56.14  ? 1328 HOH A O   1 
HETATM 5110 O  O   . HOH L 9 .   ? -16.328 -49.104 -16.279 1.00 26.81  ? 1329 HOH A O   1 
HETATM 5111 O  O   . HOH L 9 .   ? -36.152 -57.250 -3.635  1.00 58.43  ? 1330 HOH A O   1 
HETATM 5112 O  O   . HOH L 9 .   ? -12.313 -74.883 -26.290 1.00 67.75  ? 1331 HOH A O   1 
HETATM 5113 O  O   . HOH L 9 .   ? 0.588   -45.163 -36.497 1.00 47.98  ? 1332 HOH A O   1 
HETATM 5114 O  O   . HOH L 9 .   ? -0.376  -42.006 -21.296 0.46 29.39  ? 1333 HOH A O   1 
HETATM 5115 O  O   . HOH L 9 .   ? -8.413  -67.639 -28.575 1.00 52.64  ? 1334 HOH A O   1 
HETATM 5116 O  O   . HOH L 9 .   ? -31.058 -16.757 -31.163 1.00 56.01  ? 1335 HOH A O   1 
HETATM 5117 O  O   . HOH L 9 .   ? -37.722 -55.188 -24.530 1.00 64.37  ? 1336 HOH A O   1 
HETATM 5118 O  O   . HOH L 9 .   ? -11.429 -69.639 -26.399 0.48 33.56  ? 1337 HOH A O   1 
HETATM 5119 O  O   . HOH L 9 .   ? -17.819 -27.690 -44.160 1.00 53.09  ? 1338 HOH A O   1 
HETATM 5120 O  O   . HOH L 9 .   ? -34.935 -70.310 -12.610 1.00 69.49  ? 1339 HOH A O   1 
HETATM 5121 O  O   . HOH L 9 .   ? -35.120 -49.341 -23.578 1.00 69.05  ? 1340 HOH A O   1 
HETATM 5122 O  O   . HOH L 9 .   ? 0.399   -61.869 -17.445 1.00 44.60  ? 1341 HOH A O   1 
HETATM 5123 O  O   . HOH L 9 .   ? -7.988  -62.930 -31.329 0.48 38.83  ? 1342 HOH A O   1 
HETATM 5124 O  O   . HOH L 9 .   ? -21.357 -70.504 -34.263 1.00 72.31  ? 1343 HOH A O   1 
HETATM 5125 O  O   . HOH L 9 .   ? -27.464 -73.266 -4.522  1.00 61.19  ? 1344 HOH A O   1 
HETATM 5126 O  O   . HOH L 9 .   ? -37.082 -64.435 0.046   1.00 43.35  ? 1345 HOH A O   1 
HETATM 5127 O  O   . HOH L 9 .   ? -3.455  -51.762 2.650   1.00 61.13  ? 1346 HOH A O   1 
HETATM 5128 O  O   . HOH L 9 .   ? -40.339 -61.890 -2.653  1.00 61.84  ? 1347 HOH A O   1 
HETATM 5129 O  O   . HOH L 9 .   ? -15.901 -68.994 -5.995  1.00 36.84  ? 1348 HOH A O   1 
HETATM 5130 O  O   . HOH L 9 .   ? -2.751  -53.948 -36.037 1.00 68.93  ? 1349 HOH A O   1 
HETATM 5131 O  O   . HOH L 9 .   ? -4.390  -49.577 2.891   1.00 72.57  ? 1350 HOH A O   1 
HETATM 5132 O  O   . HOH L 9 .   ? -3.557  -51.975 -4.622  1.00 68.99  ? 1351 HOH A O   1 
HETATM 5133 O  O   . HOH L 9 .   ? -7.335  -74.480 -11.952 0.48 44.05  ? 1352 HOH A O   1 
HETATM 5134 O  O   . HOH L 9 .   ? -41.960 -22.913 -17.032 1.00 71.25  ? 1353 HOH A O   1 
HETATM 5135 O  O   . HOH L 9 .   ? 0.000   -57.907 -28.348 0.50 37.90  ? 1354 HOH A O   1 
HETATM 5136 O  O   . HOH L 9 .   ? 9.160   -42.527 -33.372 1.00 65.72  ? 1355 HOH A O   1 
HETATM 5137 O  O   . HOH L 9 .   ? -9.229  -70.950 -25.808 0.48 36.63  ? 1356 HOH A O   1 
HETATM 5138 O  O   . HOH L 9 .   ? -42.524 -66.180 -10.823 1.00 66.03  ? 1357 HOH A O   1 
HETATM 5139 O  O   . HOH L 9 .   ? -15.107 -45.232 -10.027 1.00 72.28  ? 1358 HOH A O   1 
HETATM 5140 O  O   . HOH L 9 .   ? -34.788 -69.938 -9.469  1.00 56.22  ? 1359 HOH A O   1 
HETATM 5141 O  O   . HOH L 9 .   ? -5.267  -66.453 -6.291  1.00 57.82  ? 1360 HOH A O   1 
HETATM 5142 O  O   . HOH L 9 .   ? -24.966 -28.502 -22.089 1.00 53.52  ? 1361 HOH A O   1 
HETATM 5143 O  O   . HOH L 9 .   ? -15.379 -41.460 -38.364 1.00 48.28  ? 1362 HOH A O   1 
HETATM 5144 O  O   . HOH L 9 .   ? -1.189  -62.706 -15.075 1.00 52.97  ? 1363 HOH A O   1 
HETATM 5145 O  O   . HOH L 9 .   ? -38.346 -52.047 -4.064  1.00 57.00  ? 1364 HOH A O   1 
HETATM 5146 O  O   . HOH L 9 .   ? -10.053 -55.285 -41.825 1.00 72.16  ? 1365 HOH A O   1 
HETATM 5147 O  O   . HOH L 9 .   ? -41.370 -56.687 -13.786 1.00 32.90  ? 1366 HOH A O   1 
HETATM 5148 O  O   . HOH L 9 .   ? -6.438  -44.140 -16.979 1.00 71.00  ? 1367 HOH A O   1 
HETATM 5149 O  O   . HOH L 9 .   ? -18.530 -39.826 -38.217 1.00 67.60  ? 1368 HOH A O   1 
HETATM 5150 O  O   . HOH L 9 .   ? 16.687  -34.608 -25.802 1.00 56.63  ? 1369 HOH A O   1 
HETATM 5151 O  O   . HOH L 9 .   ? -19.822 -58.298 -48.626 1.00 65.67  ? 1370 HOH A O   1 
HETATM 5152 O  O   . HOH L 9 .   ? -24.874 -27.705 -19.781 1.00 54.35  ? 1371 HOH A O   1 
HETATM 5153 O  O   . HOH L 9 .   ? -3.044  -60.347 -5.579  1.00 59.12  ? 1372 HOH A O   1 
HETATM 5154 O  O   . HOH L 9 .   ? -31.927 -18.960 -5.191  1.00 75.85  ? 1373 HOH A O   1 
HETATM 5155 O  O   . HOH L 9 .   ? -16.558 -39.118 -39.614 1.00 57.70  ? 1374 HOH A O   1 
HETATM 5156 O  O   . HOH L 9 .   ? -2.338  -56.245 -33.427 1.00 60.47  ? 1375 HOH A O   1 
HETATM 5157 O  O   . HOH L 9 .   ? 10.461  -42.297 -27.903 1.00 76.77  ? 1376 HOH A O   1 
HETATM 5158 O  O   . HOH L 9 .   ? -18.389 -67.585 -6.454  1.00 29.16  ? 1377 HOH A O   1 
HETATM 5159 O  O   . HOH L 9 .   ? -1.837  -55.189 -6.150  1.00 55.81  ? 1378 HOH A O   1 
HETATM 5160 O  O   . HOH L 9 .   ? -38.386 -62.670 -0.448  1.00 55.63  ? 1379 HOH A O   1 
HETATM 5161 O  O   . HOH L 9 .   ? 13.395  -41.889 -21.990 0.48 52.04  ? 1380 HOH A O   1 
HETATM 5162 O  O   . HOH L 9 .   ? -20.107 -67.776 -4.277  1.00 38.11  ? 1381 HOH A O   1 
HETATM 5163 O  O   . HOH L 9 .   ? -35.932 -47.681 -14.186 1.00 57.27  ? 1382 HOH A O   1 
HETATM 5164 O  O   . HOH L 9 .   ? -2.892  -59.270 -0.633  1.00 53.24  ? 1383 HOH A O   1 
HETATM 5165 O  O   . HOH L 9 .   ? -12.216 -35.960 -42.296 1.00 63.21  ? 1384 HOH A O   1 
HETATM 5166 O  O   . HOH L 9 .   ? -5.744  -63.919 -6.706  1.00 45.41  ? 1385 HOH A O   1 
HETATM 5167 O  O   . HOH L 9 .   ? -4.325  -60.417 -9.964  1.00 57.82  ? 1386 HOH A O   1 
HETATM 5168 O  O   . HOH L 9 .   ? -1.914  -59.135 -3.464  1.00 52.34  ? 1387 HOH A O   1 
HETATM 5169 O  O   . HOH L 9 .   ? -44.309 -67.392 -15.455 1.00 66.53  ? 1388 HOH A O   1 
HETATM 5170 O  O   . HOH L 9 .   ? 10.355  -20.220 -24.906 1.00 65.70  ? 1389 HOH A O   1 
HETATM 5171 O  O   . HOH L 9 .   ? -28.031 -55.475 -44.909 1.00 58.94  ? 1390 HOH A O   1 
HETATM 5172 O  O   . HOH L 9 .   ? -4.175  -62.493 -8.509  1.00 55.13  ? 1391 HOH A O   1 
HETATM 5173 O  O   . HOH L 9 .   ? -39.420 -53.940 -1.844  0.50 56.03  ? 1392 HOH A O   1 
# 
