data_7I2T
# 
_entry.id   7I2T 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   7I2T         pdb_00007i2t 10.2210/pdb7i2t/pdb 
WWPDB D_1001408244 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-02 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.entry_id                        7I2T 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.recvd_initial_deposition_date   2025-03-06 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.SG_entry                        ? 
_pdbx_database_status.pdb_format_compatible           Y 
_pdbx_database_status.methods_development_category    ? 
# 
_pdbx_contact_author.id                 1 
_pdbx_contact_author.email              fr193@cabm.rutgers.edu 
_pdbx_contact_author.name_first         'Francesc Xavier' 
_pdbx_contact_author.name_last          Ruiz 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0457-0030 
_pdbx_contact_author.name_mi            ? 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Aschenbrenner, J.C.' 1  ? 
'Saini, M.'           2  ? 
'Chopra, A.'          3  ? 
'Marples, P.G.'       4  ? 
'Balcomb, B.H.'       5  ? 
'Lithgo, R.M.'        6  ? 
'Fearon, D.'          7  ? 
'von Delft, F.'       8  ? 
'Ruiz, F.X.'          9  ? 
'Arnold, E.'          10 ? 
# 
_citation.id                        primary 
_citation.title                     
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_volume            ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.year                      ? 
_citation.journal_id_ASTM           ? 
_citation.country                   ? 
_citation.journal_id_ISSN           ? 
_citation.journal_id_CSD            0353 
_citation.book_publisher            ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_DOI      ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.identifier_ORCID 
_citation_author.ordinal 
primary 'Aschenbrenner, J.C.' ? 1  
primary 'Saini, M.'           ? 2  
primary 'Chopra, A.'          ? 3  
primary 'Marples, P.G.'       ? 4  
primary 'Balcomb, B.H.'       ? 5  
primary 'Lithgo, R.M.'        ? 6  
primary 'Fearon, D.'          ? 7  
primary 'von Delft, F.'       ? 8  
primary 'Ruiz, F.X.'          ? 9  
primary 'Arnold, E.'          ? 10 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'NS5 RNA-dependent RNA polymerase'                              73890.008 1   ? ? ? ? 
2 non-polymer syn 'ZINC ION'                                                      65.409    2   ? ? ? ? 
3 non-polymer syn '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                          195.237   1   ? ? ? ? 
4 non-polymer syn 'DIMETHYL SULFOXIDE'                                            78.133    2   ? ? ? ? 
5 non-polymer syn 'PHOSPHATE ION'                                                 94.971    2   ? ? ? ? 
6 non-polymer syn 'DI(HYDROXYETHYL)ETHER'                                         106.120   1   ? ? ? ? 
7 non-polymer syn 'CHLORIDE ION'                                                  35.453    1   ? ? ? ? 
8 non-polymer syn '[4-(cyclopropanecarbonyl)piperazin-1-yl](furan-2-yl)methanone' 248.278   1   ? ? ? ? 
9 water       nat water                                                           18.015    410 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION'                                                      ZN  
3 '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                          MES 
4 'DIMETHYL SULFOXIDE'                                            DMS 
5 'PHOSPHATE ION'                                                 PO4 
6 'DI(HYDROXYETHYL)ETHER'                                         PEG 
7 'CHLORIDE ION'                                                  CL  
8 '[4-(cyclopropanecarbonyl)piperazin-1-yl](furan-2-yl)methanone' JMM 
9 water                                                           HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PRO n 
1 3   GLY n 
1 4   ILE n 
1 5   GLU n 
1 6   SER n 
1 7   GLU n 
1 8   THR n 
1 9   PRO n 
1 10  ASN n 
1 11  LEU n 
1 12  ASP n 
1 13  ILE n 
1 14  ILE n 
1 15  GLY n 
1 16  LYS n 
1 17  ARG n 
1 18  ILE n 
1 19  GLU n 
1 20  LYS n 
1 21  ILE n 
1 22  LYS n 
1 23  GLN n 
1 24  GLU n 
1 25  HIS n 
1 26  GLU n 
1 27  THR n 
1 28  SER n 
1 29  TRP n 
1 30  HIS n 
1 31  TYR n 
1 32  ASP n 
1 33  GLN n 
1 34  ASP n 
1 35  HIS n 
1 36  PRO n 
1 37  TYR n 
1 38  LYS n 
1 39  THR n 
1 40  TRP n 
1 41  ALA n 
1 42  TYR n 
1 43  HIS n 
1 44  GLY n 
1 45  SER n 
1 46  TYR n 
1 47  GLU n 
1 48  THR n 
1 49  LYS n 
1 50  GLN n 
1 51  THR n 
1 52  GLY n 
1 53  SER n 
1 54  ALA n 
1 55  SER n 
1 56  SER n 
1 57  MET n 
1 58  VAL n 
1 59  ASN n 
1 60  GLY n 
1 61  VAL n 
1 62  VAL n 
1 63  ARG n 
1 64  LEU n 
1 65  LEU n 
1 66  THR n 
1 67  LYS n 
1 68  PRO n 
1 69  TRP n 
1 70  ASP n 
1 71  ILE n 
1 72  ILE n 
1 73  PRO n 
1 74  MET n 
1 75  VAL n 
1 76  THR n 
1 77  GLN n 
1 78  MET n 
1 79  ALA n 
1 80  MET n 
1 81  THR n 
1 82  ASP n 
1 83  THR n 
1 84  THR n 
1 85  PRO n 
1 86  PHE n 
1 87  GLY n 
1 88  GLN n 
1 89  GLN n 
1 90  ARG n 
1 91  VAL n 
1 92  PHE n 
1 93  LYS n 
1 94  GLU n 
1 95  LYS n 
1 96  VAL n 
1 97  ASP n 
1 98  THR n 
1 99  ARG n 
1 100 THR n 
1 101 GLN n 
1 102 GLU n 
1 103 PRO n 
1 104 LYS n 
1 105 GLU n 
1 106 GLY n 
1 107 THR n 
1 108 LYS n 
1 109 LYS n 
1 110 LEU n 
1 111 MET n 
1 112 LYS n 
1 113 ILE n 
1 114 THR n 
1 115 ALA n 
1 116 GLU n 
1 117 TRP n 
1 118 LEU n 
1 119 TRP n 
1 120 LYS n 
1 121 GLU n 
1 122 LEU n 
1 123 GLY n 
1 124 LYS n 
1 125 LYS n 
1 126 LYS n 
1 127 THR n 
1 128 PRO n 
1 129 ARG n 
1 130 MET n 
1 131 CYS n 
1 132 THR n 
1 133 ARG n 
1 134 GLU n 
1 135 GLU n 
1 136 PHE n 
1 137 THR n 
1 138 ARG n 
1 139 LYS n 
1 140 VAL n 
1 141 ARG n 
1 142 SER n 
1 143 ASN n 
1 144 ALA n 
1 145 ALA n 
1 146 LEU n 
1 147 GLY n 
1 148 ALA n 
1 149 ILE n 
1 150 PHE n 
1 151 THR n 
1 152 ASP n 
1 153 GLU n 
1 154 ASN n 
1 155 LYS n 
1 156 TRP n 
1 157 LYS n 
1 158 SER n 
1 159 ALA n 
1 160 ARG n 
1 161 GLU n 
1 162 ALA n 
1 163 VAL n 
1 164 GLU n 
1 165 ASP n 
1 166 SER n 
1 167 GLY n 
1 168 PHE n 
1 169 TRP n 
1 170 GLU n 
1 171 LEU n 
1 172 VAL n 
1 173 ASP n 
1 174 LYS n 
1 175 GLU n 
1 176 ARG n 
1 177 ASN n 
1 178 LEU n 
1 179 HIS n 
1 180 LEU n 
1 181 GLU n 
1 182 GLY n 
1 183 LYS n 
1 184 CYS n 
1 185 GLU n 
1 186 THR n 
1 187 CYS n 
1 188 VAL n 
1 189 TYR n 
1 190 ASN n 
1 191 MET n 
1 192 MET n 
1 193 GLY n 
1 194 LYS n 
1 195 ARG n 
1 196 GLU n 
1 197 LYS n 
1 198 LYS n 
1 199 LEU n 
1 200 GLY n 
1 201 GLU n 
1 202 PHE n 
1 203 GLY n 
1 204 LYS n 
1 205 ALA n 
1 206 LYS n 
1 207 GLY n 
1 208 SER n 
1 209 ARG n 
1 210 ALA n 
1 211 ILE n 
1 212 TRP n 
1 213 TYR n 
1 214 MET n 
1 215 TRP n 
1 216 LEU n 
1 217 GLY n 
1 218 ALA n 
1 219 ARG n 
1 220 PHE n 
1 221 LEU n 
1 222 GLU n 
1 223 PHE n 
1 224 GLU n 
1 225 ALA n 
1 226 LEU n 
1 227 GLY n 
1 228 PHE n 
1 229 LEU n 
1 230 ASN n 
1 231 GLU n 
1 232 ASP n 
1 233 HIS n 
1 234 TRP n 
1 235 PHE n 
1 236 SER n 
1 237 ARG n 
1 238 GLU n 
1 239 ASN n 
1 240 SER n 
1 241 LEU n 
1 242 SER n 
1 243 GLY n 
1 244 VAL n 
1 245 GLU n 
1 246 GLY n 
1 247 GLU n 
1 248 GLY n 
1 249 LEU n 
1 250 HIS n 
1 251 LYS n 
1 252 LEU n 
1 253 GLY n 
1 254 TYR n 
1 255 ILE n 
1 256 LEU n 
1 257 ARG n 
1 258 ASP n 
1 259 VAL n 
1 260 SER n 
1 261 LYS n 
1 262 LYS n 
1 263 GLU n 
1 264 GLY n 
1 265 GLY n 
1 266 ALA n 
1 267 MET n 
1 268 TYR n 
1 269 ALA n 
1 270 ASP n 
1 271 ASP n 
1 272 THR n 
1 273 ALA n 
1 274 GLY n 
1 275 TRP n 
1 276 ASP n 
1 277 THR n 
1 278 ARG n 
1 279 ILE n 
1 280 THR n 
1 281 LEU n 
1 282 GLU n 
1 283 ASP n 
1 284 LEU n 
1 285 LYS n 
1 286 ASN n 
1 287 GLU n 
1 288 GLU n 
1 289 MET n 
1 290 VAL n 
1 291 THR n 
1 292 ASN n 
1 293 HIS n 
1 294 MET n 
1 295 GLU n 
1 296 GLY n 
1 297 GLU n 
1 298 HIS n 
1 299 LYS n 
1 300 LYS n 
1 301 LEU n 
1 302 ALA n 
1 303 GLU n 
1 304 ALA n 
1 305 ILE n 
1 306 PHE n 
1 307 LYS n 
1 308 LEU n 
1 309 THR n 
1 310 TYR n 
1 311 GLN n 
1 312 ASN n 
1 313 LYS n 
1 314 VAL n 
1 315 VAL n 
1 316 ARG n 
1 317 VAL n 
1 318 GLN n 
1 319 ARG n 
1 320 PRO n 
1 321 THR n 
1 322 PRO n 
1 323 ARG n 
1 324 GLY n 
1 325 THR n 
1 326 VAL n 
1 327 MET n 
1 328 ASP n 
1 329 ILE n 
1 330 ILE n 
1 331 SER n 
1 332 ARG n 
1 333 ARG n 
1 334 ASP n 
1 335 GLN n 
1 336 ARG n 
1 337 GLY n 
1 338 SER n 
1 339 GLY n 
1 340 GLN n 
1 341 VAL n 
1 342 VAL n 
1 343 THR n 
1 344 TYR n 
1 345 GLY n 
1 346 LEU n 
1 347 ASN n 
1 348 THR n 
1 349 PHE n 
1 350 THR n 
1 351 ASN n 
1 352 MET n 
1 353 GLU n 
1 354 ALA n 
1 355 GLN n 
1 356 LEU n 
1 357 ILE n 
1 358 ARG n 
1 359 GLN n 
1 360 MET n 
1 361 GLU n 
1 362 GLY n 
1 363 GLU n 
1 364 GLY n 
1 365 VAL n 
1 366 PHE n 
1 367 LYS n 
1 368 SER n 
1 369 ILE n 
1 370 GLN n 
1 371 HIS n 
1 372 LEU n 
1 373 THR n 
1 374 VAL n 
1 375 THR n 
1 376 GLU n 
1 377 GLU n 
1 378 ILE n 
1 379 ALA n 
1 380 VAL n 
1 381 LYS n 
1 382 ASN n 
1 383 TRP n 
1 384 LEU n 
1 385 VAL n 
1 386 ARG n 
1 387 VAL n 
1 388 GLY n 
1 389 ARG n 
1 390 GLU n 
1 391 ARG n 
1 392 LEU n 
1 393 SER n 
1 394 ARG n 
1 395 MET n 
1 396 ALA n 
1 397 ILE n 
1 398 SER n 
1 399 GLY n 
1 400 ASP n 
1 401 ASP n 
1 402 CYS n 
1 403 VAL n 
1 404 VAL n 
1 405 LYS n 
1 406 PRO n 
1 407 LEU n 
1 408 ASP n 
1 409 ASP n 
1 410 ARG n 
1 411 PHE n 
1 412 ALA n 
1 413 SER n 
1 414 ALA n 
1 415 LEU n 
1 416 THR n 
1 417 ALA n 
1 418 LEU n 
1 419 ASN n 
1 420 ASP n 
1 421 MET n 
1 422 GLY n 
1 423 LYS n 
1 424 VAL n 
1 425 ARG n 
1 426 LYS n 
1 427 ASP n 
1 428 ILE n 
1 429 GLN n 
1 430 GLN n 
1 431 TRP n 
1 432 GLU n 
1 433 PRO n 
1 434 SER n 
1 435 ARG n 
1 436 GLY n 
1 437 TRP n 
1 438 ASN n 
1 439 ASP n 
1 440 TRP n 
1 441 THR n 
1 442 GLN n 
1 443 VAL n 
1 444 PRO n 
1 445 PHE n 
1 446 CYS n 
1 447 SER n 
1 448 HIS n 
1 449 HIS n 
1 450 PHE n 
1 451 HIS n 
1 452 GLU n 
1 453 LEU n 
1 454 ILE n 
1 455 MET n 
1 456 LYS n 
1 457 ASP n 
1 458 GLY n 
1 459 ARG n 
1 460 VAL n 
1 461 LEU n 
1 462 VAL n 
1 463 VAL n 
1 464 PRO n 
1 465 CYS n 
1 466 ARG n 
1 467 ASN n 
1 468 GLN n 
1 469 ASP n 
1 470 GLU n 
1 471 LEU n 
1 472 ILE n 
1 473 GLY n 
1 474 ARG n 
1 475 ALA n 
1 476 ARG n 
1 477 ILE n 
1 478 SER n 
1 479 GLN n 
1 480 GLY n 
1 481 ALA n 
1 482 GLY n 
1 483 TRP n 
1 484 SER n 
1 485 LEU n 
1 486 ARG n 
1 487 GLU n 
1 488 THR n 
1 489 ALA n 
1 490 CYS n 
1 491 LEU n 
1 492 GLY n 
1 493 LYS n 
1 494 SER n 
1 495 TYR n 
1 496 ALA n 
1 497 GLN n 
1 498 MET n 
1 499 TRP n 
1 500 SER n 
1 501 LEU n 
1 502 MET n 
1 503 TYR n 
1 504 PHE n 
1 505 HIS n 
1 506 ARG n 
1 507 ARG n 
1 508 ASP n 
1 509 LEU n 
1 510 ARG n 
1 511 LEU n 
1 512 ALA n 
1 513 ALA n 
1 514 ASN n 
1 515 ALA n 
1 516 ILE n 
1 517 CYS n 
1 518 SER n 
1 519 ALA n 
1 520 VAL n 
1 521 PRO n 
1 522 SER n 
1 523 HIS n 
1 524 TRP n 
1 525 VAL n 
1 526 PRO n 
1 527 THR n 
1 528 SER n 
1 529 ARG n 
1 530 THR n 
1 531 THR n 
1 532 TRP n 
1 533 SER n 
1 534 ILE n 
1 535 HIS n 
1 536 ALA n 
1 537 THR n 
1 538 HIS n 
1 539 GLU n 
1 540 TRP n 
1 541 MET n 
1 542 THR n 
1 543 THR n 
1 544 GLU n 
1 545 ASP n 
1 546 MET n 
1 547 LEU n 
1 548 THR n 
1 549 VAL n 
1 550 TRP n 
1 551 ASN n 
1 552 ARG n 
1 553 VAL n 
1 554 TRP n 
1 555 ILE n 
1 556 GLN n 
1 557 GLU n 
1 558 ASN n 
1 559 PRO n 
1 560 TRP n 
1 561 MET n 
1 562 GLU n 
1 563 ASP n 
1 564 LYS n 
1 565 THR n 
1 566 PRO n 
1 567 VAL n 
1 568 GLU n 
1 569 SER n 
1 570 TRP n 
1 571 GLU n 
1 572 GLU n 
1 573 ILE n 
1 574 PRO n 
1 575 TYR n 
1 576 LEU n 
1 577 GLY n 
1 578 LYS n 
1 579 ARG n 
1 580 GLU n 
1 581 ASP n 
1 582 GLN n 
1 583 TRP n 
1 584 CYS n 
1 585 GLY n 
1 586 SER n 
1 587 LEU n 
1 588 ILE n 
1 589 GLY n 
1 590 LEU n 
1 591 THR n 
1 592 SER n 
1 593 ARG n 
1 594 ALA n 
1 595 THR n 
1 596 TRP n 
1 597 ALA n 
1 598 LYS n 
1 599 ASN n 
1 600 ILE n 
1 601 GLN n 
1 602 THR n 
1 603 ALA n 
1 604 ILE n 
1 605 ASN n 
1 606 GLN n 
1 607 VAL n 
1 608 ARG n 
1 609 SER n 
1 610 LEU n 
1 611 ILE n 
1 612 GLY n 
1 613 ASN n 
1 614 GLU n 
1 615 GLU n 
1 616 TYR n 
1 617 THR n 
1 618 ASP n 
1 619 TYR n 
1 620 MET n 
1 621 PRO n 
1 622 SER n 
1 623 MET n 
1 624 LYS n 
1 625 ARG n 
1 626 PHE n 
1 627 ARG n 
1 628 ARG n 
1 629 GLU n 
1 630 GLU n 
1 631 GLU n 
1 632 GLU n 
1 633 ALA n 
1 634 GLY n 
1 635 VAL n 
1 636 LEU n 
1 637 TRP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   637 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'dengue virus type 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     11060 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                                         ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                                        ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                                      ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                                 ? 'C4 H7 N O4'     133.103 
CL  non-polymer         . 'CHLORIDE ION'                                                  ? 'Cl -1'          35.453  
CYS 'L-peptide linking' y CYSTEINE                                                        ? 'C3 H7 N O2 S'   121.158 
DMS non-polymer         . 'DIMETHYL SULFOXIDE'                                            ? 'C2 H6 O S'      78.133  
GLN 'L-peptide linking' y GLUTAMINE                                                       ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                                 ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                                         ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                                       ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                                           ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                                      ? 'C6 H13 N O2'    131.173 
JMM non-polymer         . '[4-(cyclopropanecarbonyl)piperazin-1-yl](furan-2-yl)methanone' ? 'C13 H16 N2 O3'  248.278 
LEU 'L-peptide linking' y LEUCINE                                                         ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                                          ? 'C6 H15 N2 O2 1' 147.195 
MES non-polymer         . '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                          ? 'C6 H13 N O4 S'  195.237 
MET 'L-peptide linking' y METHIONINE                                                      ? 'C5 H11 N O2 S'  149.211 
PEG non-polymer         . 'DI(HYDROXYETHYL)ETHER'                                         ? 'C4 H10 O3'      106.120 
PHE 'L-peptide linking' y PHENYLALANINE                                                   ? 'C9 H11 N O2'    165.189 
PO4 non-polymer         . 'PHOSPHATE ION'                                                 ? 'O4 P -3'        94.971  
PRO 'L-peptide linking' y PROLINE                                                         ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                                          ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                                       ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                                      ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                                        ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                                                          ? 'C5 H11 N O2'    117.146 
ZN  non-polymer         . 'ZINC ION'                                                      ? 'Zn 2'           65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   264 ?   ?   ?   A . n 
A 1 2   PRO 2   265 ?   ?   ?   A . n 
A 1 3   GLY 3   266 ?   ?   ?   A . n 
A 1 4   ILE 4   267 ?   ?   ?   A . n 
A 1 5   GLU 5   268 ?   ?   ?   A . n 
A 1 6   SER 6   269 ?   ?   ?   A . n 
A 1 7   GLU 7   270 ?   ?   ?   A . n 
A 1 8   THR 8   271 ?   ?   ?   A . n 
A 1 9   PRO 9   272 ?   ?   ?   A . n 
A 1 10  ASN 10  273 273 ASN ASN A . n 
A 1 11  LEU 11  274 274 LEU LEU A . n 
A 1 12  ASP 12  275 275 ASP ASP A . n 
A 1 13  ILE 13  276 276 ILE ILE A . n 
A 1 14  ILE 14  277 277 ILE ILE A . n 
A 1 15  GLY 15  278 278 GLY GLY A . n 
A 1 16  LYS 16  279 279 LYS LYS A . n 
A 1 17  ARG 17  280 280 ARG ARG A . n 
A 1 18  ILE 18  281 281 ILE ILE A . n 
A 1 19  GLU 19  282 282 GLU GLU A . n 
A 1 20  LYS 20  283 283 LYS LYS A . n 
A 1 21  ILE 21  284 284 ILE ILE A . n 
A 1 22  LYS 22  285 285 LYS LYS A . n 
A 1 23  GLN 23  286 286 GLN GLN A . n 
A 1 24  GLU 24  287 287 GLU GLU A . n 
A 1 25  HIS 25  288 288 HIS HIS A . n 
A 1 26  GLU 26  289 289 GLU GLU A . n 
A 1 27  THR 27  290 290 THR THR A . n 
A 1 28  SER 28  291 291 SER SER A . n 
A 1 29  TRP 29  292 292 TRP TRP A . n 
A 1 30  HIS 30  293 293 HIS HIS A . n 
A 1 31  TYR 31  294 294 TYR TYR A . n 
A 1 32  ASP 32  295 295 ASP ASP A . n 
A 1 33  GLN 33  296 296 GLN GLN A . n 
A 1 34  ASP 34  297 297 ASP ASP A . n 
A 1 35  HIS 35  298 298 HIS HIS A . n 
A 1 36  PRO 36  299 299 PRO PRO A . n 
A 1 37  TYR 37  300 300 TYR TYR A . n 
A 1 38  LYS 38  301 301 LYS LYS A . n 
A 1 39  THR 39  302 302 THR THR A . n 
A 1 40  TRP 40  303 303 TRP TRP A . n 
A 1 41  ALA 41  304 304 ALA ALA A . n 
A 1 42  TYR 42  305 305 TYR TYR A . n 
A 1 43  HIS 43  306 306 HIS HIS A . n 
A 1 44  GLY 44  307 307 GLY GLY A . n 
A 1 45  SER 45  308 308 SER SER A . n 
A 1 46  TYR 46  309 309 TYR TYR A . n 
A 1 47  GLU 47  310 310 GLU GLU A . n 
A 1 48  THR 48  311 311 THR THR A . n 
A 1 49  LYS 49  312 ?   ?   ?   A . n 
A 1 50  GLN 50  313 ?   ?   ?   A . n 
A 1 51  THR 51  314 ?   ?   ?   A . n 
A 1 52  GLY 52  315 ?   ?   ?   A . n 
A 1 53  SER 53  316 ?   ?   ?   A . n 
A 1 54  ALA 54  317 317 ALA ALA A . n 
A 1 55  SER 55  318 318 SER SER A . n 
A 1 56  SER 56  319 319 SER SER A . n 
A 1 57  MET 57  320 320 MET MET A . n 
A 1 58  VAL 58  321 321 VAL VAL A . n 
A 1 59  ASN 59  322 322 ASN ASN A . n 
A 1 60  GLY 60  323 323 GLY GLY A . n 
A 1 61  VAL 61  324 324 VAL VAL A . n 
A 1 62  VAL 62  325 325 VAL VAL A . n 
A 1 63  ARG 63  326 326 ARG ARG A . n 
A 1 64  LEU 64  327 327 LEU LEU A . n 
A 1 65  LEU 65  328 328 LEU LEU A . n 
A 1 66  THR 66  329 329 THR THR A . n 
A 1 67  LYS 67  330 330 LYS LYS A . n 
A 1 68  PRO 68  331 331 PRO PRO A . n 
A 1 69  TRP 69  332 332 TRP TRP A . n 
A 1 70  ASP 70  333 333 ASP ASP A . n 
A 1 71  ILE 71  334 334 ILE ILE A . n 
A 1 72  ILE 72  335 335 ILE ILE A . n 
A 1 73  PRO 73  336 336 PRO PRO A . n 
A 1 74  MET 74  337 337 MET MET A . n 
A 1 75  VAL 75  338 338 VAL VAL A . n 
A 1 76  THR 76  339 339 THR THR A . n 
A 1 77  GLN 77  340 340 GLN GLN A . n 
A 1 78  MET 78  341 341 MET MET A . n 
A 1 79  ALA 79  342 342 ALA ALA A . n 
A 1 80  MET 80  343 343 MET MET A . n 
A 1 81  THR 81  344 344 THR GLY A . n 
A 1 82  ASP 82  345 ?   ?   ?   A . n 
A 1 83  THR 83  346 ?   ?   ?   A . n 
A 1 84  THR 84  347 ?   ?   ?   A . n 
A 1 85  PRO 85  348 ?   ?   ?   A . n 
A 1 86  PHE 86  349 ?   ?   ?   A . n 
A 1 87  GLY 87  350 ?   ?   ?   A . n 
A 1 88  GLN 88  351 ?   ?   ?   A . n 
A 1 89  GLN 89  352 ?   ?   ?   A . n 
A 1 90  ARG 90  353 ?   ?   ?   A . n 
A 1 91  VAL 91  354 ?   ?   ?   A . n 
A 1 92  PHE 92  355 ?   ?   ?   A . n 
A 1 93  LYS 93  356 356 LYS LYS A . n 
A 1 94  GLU 94  357 357 GLU GLU A . n 
A 1 95  LYS 95  358 358 LYS LYS A . n 
A 1 96  VAL 96  359 359 VAL VAL A . n 
A 1 97  ASP 97  360 360 ASP ASP A . n 
A 1 98  THR 98  361 361 THR THR A . n 
A 1 99  ARG 99  362 362 ARG ARG A . n 
A 1 100 THR 100 363 363 THR THR A . n 
A 1 101 GLN 101 364 364 GLN GLN A . n 
A 1 102 GLU 102 365 365 GLU GLU A . n 
A 1 103 PRO 103 366 366 PRO PRO A . n 
A 1 104 LYS 104 367 367 LYS LYS A . n 
A 1 105 GLU 105 368 368 GLU GLU A . n 
A 1 106 GLY 106 369 369 GLY GLY A . n 
A 1 107 THR 107 370 370 THR THR A . n 
A 1 108 LYS 108 371 371 LYS LYS A . n 
A 1 109 LYS 109 372 372 LYS LYS A . n 
A 1 110 LEU 110 373 373 LEU LEU A . n 
A 1 111 MET 111 374 374 MET MET A . n 
A 1 112 LYS 112 375 375 LYS LYS A . n 
A 1 113 ILE 113 376 376 ILE ILE A . n 
A 1 114 THR 114 377 377 THR THR A . n 
A 1 115 ALA 115 378 378 ALA ALA A . n 
A 1 116 GLU 116 379 379 GLU GLU A . n 
A 1 117 TRP 117 380 380 TRP TRP A . n 
A 1 118 LEU 118 381 381 LEU LEU A . n 
A 1 119 TRP 119 382 382 TRP TRP A . n 
A 1 120 LYS 120 383 383 LYS LYS A . n 
A 1 121 GLU 121 384 384 GLU GLU A . n 
A 1 122 LEU 122 385 385 LEU LEU A . n 
A 1 123 GLY 123 386 386 GLY GLY A . n 
A 1 124 LYS 124 387 387 LYS LYS A . n 
A 1 125 LYS 125 388 388 LYS LYS A . n 
A 1 126 LYS 126 389 389 LYS LYS A . n 
A 1 127 THR 127 390 390 THR THR A . n 
A 1 128 PRO 128 391 391 PRO PRO A . n 
A 1 129 ARG 129 392 392 ARG ARG A . n 
A 1 130 MET 130 393 393 MET MET A . n 
A 1 131 CYS 131 394 394 CYS CYS A . n 
A 1 132 THR 132 395 395 THR THR A . n 
A 1 133 ARG 133 396 396 ARG ARG A . n 
A 1 134 GLU 134 397 397 GLU GLU A . n 
A 1 135 GLU 135 398 398 GLU GLU A . n 
A 1 136 PHE 136 399 399 PHE PHE A . n 
A 1 137 THR 137 400 400 THR THR A . n 
A 1 138 ARG 138 401 401 ARG ARG A . n 
A 1 139 LYS 139 402 402 LYS LYS A . n 
A 1 140 VAL 140 403 403 VAL VAL A . n 
A 1 141 ARG 141 404 404 ARG ARG A . n 
A 1 142 SER 142 405 405 SER SER A . n 
A 1 143 ASN 143 406 406 ASN ASN A . n 
A 1 144 ALA 144 407 ?   ?   ?   A . n 
A 1 145 ALA 145 408 ?   ?   ?   A . n 
A 1 146 LEU 146 409 ?   ?   ?   A . n 
A 1 147 GLY 147 410 ?   ?   ?   A . n 
A 1 148 ALA 148 411 ?   ?   ?   A . n 
A 1 149 ILE 149 412 ?   ?   ?   A . n 
A 1 150 PHE 150 413 ?   ?   ?   A . n 
A 1 151 THR 151 414 ?   ?   ?   A . n 
A 1 152 ASP 152 415 ?   ?   ?   A . n 
A 1 153 GLU 153 416 ?   ?   ?   A . n 
A 1 154 ASN 154 417 ?   ?   ?   A . n 
A 1 155 LYS 155 418 418 LYS LYS A . n 
A 1 156 TRP 156 419 419 TRP TRP A . n 
A 1 157 LYS 157 420 420 LYS LYS A . n 
A 1 158 SER 158 421 421 SER SER A . n 
A 1 159 ALA 159 422 422 ALA ALA A . n 
A 1 160 ARG 160 423 423 ARG ARG A . n 
A 1 161 GLU 161 424 424 GLU GLU A . n 
A 1 162 ALA 162 425 425 ALA ALA A . n 
A 1 163 VAL 163 426 426 VAL VAL A . n 
A 1 164 GLU 164 427 427 GLU GLU A . n 
A 1 165 ASP 165 428 428 ASP ASP A . n 
A 1 166 SER 166 429 429 SER SER A . n 
A 1 167 GLY 167 430 430 GLY GLY A . n 
A 1 168 PHE 168 431 431 PHE PHE A . n 
A 1 169 TRP 169 432 432 TRP TRP A . n 
A 1 170 GLU 170 433 433 GLU GLU A . n 
A 1 171 LEU 171 434 434 LEU LEU A . n 
A 1 172 VAL 172 435 435 VAL VAL A . n 
A 1 173 ASP 173 436 436 ASP ASP A . n 
A 1 174 LYS 174 437 437 LYS LYS A . n 
A 1 175 GLU 175 438 438 GLU GLU A . n 
A 1 176 ARG 176 439 439 ARG ARG A . n 
A 1 177 ASN 177 440 440 ASN ASN A . n 
A 1 178 LEU 178 441 441 LEU LEU A . n 
A 1 179 HIS 179 442 442 HIS HIS A . n 
A 1 180 LEU 180 443 443 LEU LEU A . n 
A 1 181 GLU 181 444 444 GLU GLU A . n 
A 1 182 GLY 182 445 445 GLY GLY A . n 
A 1 183 LYS 183 446 446 LYS LYS A . n 
A 1 184 CYS 184 447 447 CYS CYS A . n 
A 1 185 GLU 185 448 448 GLU GLU A . n 
A 1 186 THR 186 449 449 THR THR A . n 
A 1 187 CYS 187 450 450 CYS CYS A . n 
A 1 188 VAL 188 451 451 VAL VAL A . n 
A 1 189 TYR 189 452 452 TYR TYR A . n 
A 1 190 ASN 190 453 453 ASN ASN A . n 
A 1 191 MET 191 454 454 MET MET A . n 
A 1 192 MET 192 455 455 MET MET A . n 
A 1 193 GLY 193 456 ?   ?   ?   A . n 
A 1 194 LYS 194 457 ?   ?   ?   A . n 
A 1 195 ARG 195 458 ?   ?   ?   A . n 
A 1 196 GLU 196 459 ?   ?   ?   A . n 
A 1 197 LYS 197 460 ?   ?   ?   A . n 
A 1 198 LYS 198 461 ?   ?   ?   A . n 
A 1 199 LEU 199 462 ?   ?   ?   A . n 
A 1 200 GLY 200 463 ?   ?   ?   A . n 
A 1 201 GLU 201 464 ?   ?   ?   A . n 
A 1 202 PHE 202 465 ?   ?   ?   A . n 
A 1 203 GLY 203 466 ?   ?   ?   A . n 
A 1 204 LYS 204 467 ?   ?   ?   A . n 
A 1 205 ALA 205 468 ?   ?   ?   A . n 
A 1 206 LYS 206 469 ?   ?   ?   A . n 
A 1 207 GLY 207 470 ?   ?   ?   A . n 
A 1 208 SER 208 471 471 SER SER A . n 
A 1 209 ARG 209 472 472 ARG ARG A . n 
A 1 210 ALA 210 473 473 ALA ALA A . n 
A 1 211 ILE 211 474 474 ILE ILE A . n 
A 1 212 TRP 212 475 475 TRP TRP A . n 
A 1 213 TYR 213 476 476 TYR TYR A . n 
A 1 214 MET 214 477 477 MET MET A . n 
A 1 215 TRP 215 478 478 TRP TRP A . n 
A 1 216 LEU 216 479 479 LEU LEU A . n 
A 1 217 GLY 217 480 480 GLY GLY A . n 
A 1 218 ALA 218 481 481 ALA ALA A . n 
A 1 219 ARG 219 482 482 ARG ARG A . n 
A 1 220 PHE 220 483 483 PHE PHE A . n 
A 1 221 LEU 221 484 484 LEU LEU A . n 
A 1 222 GLU 222 485 485 GLU GLU A . n 
A 1 223 PHE 223 486 486 PHE PHE A . n 
A 1 224 GLU 224 487 487 GLU GLU A . n 
A 1 225 ALA 225 488 488 ALA ALA A . n 
A 1 226 LEU 226 489 489 LEU LEU A . n 
A 1 227 GLY 227 490 490 GLY GLY A . n 
A 1 228 PHE 228 491 491 PHE PHE A . n 
A 1 229 LEU 229 492 492 LEU LEU A . n 
A 1 230 ASN 230 493 493 ASN ASN A . n 
A 1 231 GLU 231 494 494 GLU GLU A . n 
A 1 232 ASP 232 495 495 ASP ASP A . n 
A 1 233 HIS 233 496 496 HIS HIS A . n 
A 1 234 TRP 234 497 497 TRP TRP A . n 
A 1 235 PHE 235 498 498 PHE PHE A . n 
A 1 236 SER 236 499 499 SER SER A . n 
A 1 237 ARG 237 500 500 ARG ARG A . n 
A 1 238 GLU 238 501 501 GLU GLU A . n 
A 1 239 ASN 239 502 502 ASN ASN A . n 
A 1 240 SER 240 503 503 SER SER A . n 
A 1 241 LEU 241 504 504 LEU LEU A . n 
A 1 242 SER 242 505 505 SER SER A . n 
A 1 243 GLY 243 506 506 GLY GLY A . n 
A 1 244 VAL 244 507 507 VAL VAL A . n 
A 1 245 GLU 245 508 508 GLU GLU A . n 
A 1 246 GLY 246 509 509 GLY GLY A . n 
A 1 247 GLU 247 510 510 GLU GLU A . n 
A 1 248 GLY 248 511 511 GLY GLY A . n 
A 1 249 LEU 249 512 512 LEU LEU A . n 
A 1 250 HIS 250 513 513 HIS HIS A . n 
A 1 251 LYS 251 514 514 LYS LYS A . n 
A 1 252 LEU 252 515 515 LEU LEU A . n 
A 1 253 GLY 253 516 516 GLY GLY A . n 
A 1 254 TYR 254 517 517 TYR TYR A . n 
A 1 255 ILE 255 518 518 ILE ILE A . n 
A 1 256 LEU 256 519 519 LEU LEU A . n 
A 1 257 ARG 257 520 520 ARG ARG A . n 
A 1 258 ASP 258 521 521 ASP ASP A . n 
A 1 259 VAL 259 522 522 VAL VAL A . n 
A 1 260 SER 260 523 523 SER SER A . n 
A 1 261 LYS 261 524 524 LYS LYS A . n 
A 1 262 LYS 262 525 525 LYS LYS A . n 
A 1 263 GLU 263 526 526 GLU GLU A . n 
A 1 264 GLY 264 527 527 GLY GLY A . n 
A 1 265 GLY 265 528 528 GLY GLY A . n 
A 1 266 ALA 266 529 529 ALA ALA A . n 
A 1 267 MET 267 530 530 MET MET A . n 
A 1 268 TYR 268 531 531 TYR TYR A . n 
A 1 269 ALA 269 532 532 ALA ALA A . n 
A 1 270 ASP 270 533 533 ASP ASP A . n 
A 1 271 ASP 271 534 534 ASP ASP A . n 
A 1 272 THR 272 535 535 THR THR A . n 
A 1 273 ALA 273 536 536 ALA ALA A . n 
A 1 274 GLY 274 537 537 GLY GLY A . n 
A 1 275 TRP 275 538 538 TRP TRP A . n 
A 1 276 ASP 276 539 539 ASP ASP A . n 
A 1 277 THR 277 540 540 THR THR A . n 
A 1 278 ARG 278 541 541 ARG ARG A . n 
A 1 279 ILE 279 542 542 ILE ILE A . n 
A 1 280 THR 280 543 543 THR THR A . n 
A 1 281 LEU 281 544 544 LEU LEU A . n 
A 1 282 GLU 282 545 545 GLU GLU A . n 
A 1 283 ASP 283 546 546 ASP ASP A . n 
A 1 284 LEU 284 547 547 LEU LEU A . n 
A 1 285 LYS 285 548 548 LYS LYS A . n 
A 1 286 ASN 286 549 549 ASN ASN A . n 
A 1 287 GLU 287 550 550 GLU GLU A . n 
A 1 288 GLU 288 551 551 GLU GLU A . n 
A 1 289 MET 289 552 552 MET MET A . n 
A 1 290 VAL 290 553 553 VAL VAL A . n 
A 1 291 THR 291 554 554 THR THR A . n 
A 1 292 ASN 292 555 555 ASN ASN A . n 
A 1 293 HIS 293 556 556 HIS HIS A . n 
A 1 294 MET 294 557 557 MET MET A . n 
A 1 295 GLU 295 558 558 GLU GLU A . n 
A 1 296 GLY 296 559 559 GLY GLY A . n 
A 1 297 GLU 297 560 560 GLU GLU A . n 
A 1 298 HIS 298 561 561 HIS HIS A . n 
A 1 299 LYS 299 562 562 LYS LYS A . n 
A 1 300 LYS 300 563 563 LYS LYS A . n 
A 1 301 LEU 301 564 564 LEU LEU A . n 
A 1 302 ALA 302 565 565 ALA ALA A . n 
A 1 303 GLU 303 566 566 GLU GLU A . n 
A 1 304 ALA 304 567 567 ALA ALA A . n 
A 1 305 ILE 305 568 568 ILE ILE A . n 
A 1 306 PHE 306 569 569 PHE PHE A . n 
A 1 307 LYS 307 570 570 LYS LYS A . n 
A 1 308 LEU 308 571 571 LEU LEU A . n 
A 1 309 THR 309 572 572 THR THR A . n 
A 1 310 TYR 310 573 573 TYR TYR A . n 
A 1 311 GLN 311 574 574 GLN GLN A . n 
A 1 312 ASN 312 575 575 ASN ASN A . n 
A 1 313 LYS 313 576 576 LYS LYS A . n 
A 1 314 VAL 314 577 577 VAL VAL A . n 
A 1 315 VAL 315 578 578 VAL VAL A . n 
A 1 316 ARG 316 579 579 ARG ARG A . n 
A 1 317 VAL 317 580 580 VAL VAL A . n 
A 1 318 GLN 318 581 581 GLN GLN A . n 
A 1 319 ARG 319 582 582 ARG ARG A . n 
A 1 320 PRO 320 583 583 PRO PRO A . n 
A 1 321 THR 321 584 584 THR THR A . n 
A 1 322 PRO 322 585 ?   ?   ?   A . n 
A 1 323 ARG 323 586 ?   ?   ?   A . n 
A 1 324 GLY 324 587 ?   ?   ?   A . n 
A 1 325 THR 325 588 588 THR THR A . n 
A 1 326 VAL 326 589 589 VAL VAL A . n 
A 1 327 MET 327 590 590 MET MET A . n 
A 1 328 ASP 328 591 591 ASP ASP A . n 
A 1 329 ILE 329 592 592 ILE ILE A . n 
A 1 330 ILE 330 593 593 ILE ILE A . n 
A 1 331 SER 331 594 594 SER SER A . n 
A 1 332 ARG 332 595 595 ARG ARG A . n 
A 1 333 ARG 333 596 596 ARG ARG A . n 
A 1 334 ASP 334 597 597 ASP ASP A . n 
A 1 335 GLN 335 598 598 GLN GLN A . n 
A 1 336 ARG 336 599 599 ARG ARG A . n 
A 1 337 GLY 337 600 600 GLY GLY A . n 
A 1 338 SER 338 601 601 SER SER A . n 
A 1 339 GLY 339 602 602 GLY GLY A . n 
A 1 340 GLN 340 603 603 GLN GLN A . n 
A 1 341 VAL 341 604 604 VAL VAL A . n 
A 1 342 VAL 342 605 605 VAL VAL A . n 
A 1 343 THR 343 606 606 THR THR A . n 
A 1 344 TYR 344 607 607 TYR TYR A . n 
A 1 345 GLY 345 608 608 GLY GLY A . n 
A 1 346 LEU 346 609 609 LEU LEU A . n 
A 1 347 ASN 347 610 610 ASN ASN A . n 
A 1 348 THR 348 611 611 THR THR A . n 
A 1 349 PHE 349 612 612 PHE PHE A . n 
A 1 350 THR 350 613 613 THR THR A . n 
A 1 351 ASN 351 614 614 ASN ASN A . n 
A 1 352 MET 352 615 615 MET MET A . n 
A 1 353 GLU 353 616 616 GLU GLU A . n 
A 1 354 ALA 354 617 617 ALA ALA A . n 
A 1 355 GLN 355 618 618 GLN GLN A . n 
A 1 356 LEU 356 619 619 LEU LEU A . n 
A 1 357 ILE 357 620 620 ILE ILE A . n 
A 1 358 ARG 358 621 621 ARG ARG A . n 
A 1 359 GLN 359 622 622 GLN GLN A . n 
A 1 360 MET 360 623 623 MET MET A . n 
A 1 361 GLU 361 624 624 GLU GLU A . n 
A 1 362 GLY 362 625 625 GLY GLY A . n 
A 1 363 GLU 363 626 626 GLU GLU A . n 
A 1 364 GLY 364 627 627 GLY GLY A . n 
A 1 365 VAL 365 628 628 VAL VAL A . n 
A 1 366 PHE 366 629 629 PHE PHE A . n 
A 1 367 LYS 367 630 630 LYS LYS A . n 
A 1 368 SER 368 631 631 SER SER A . n 
A 1 369 ILE 369 632 632 ILE ILE A . n 
A 1 370 GLN 370 633 633 GLN GLN A . n 
A 1 371 HIS 371 634 634 HIS HIS A . n 
A 1 372 LEU 372 635 635 LEU LEU A . n 
A 1 373 THR 373 636 636 THR THR A . n 
A 1 374 VAL 374 637 637 VAL VAL A . n 
A 1 375 THR 375 638 638 THR THR A . n 
A 1 376 GLU 376 639 639 GLU GLU A . n 
A 1 377 GLU 377 640 640 GLU GLU A . n 
A 1 378 ILE 378 641 641 ILE ILE A . n 
A 1 379 ALA 379 642 642 ALA ALA A . n 
A 1 380 VAL 380 643 643 VAL VAL A . n 
A 1 381 LYS 381 644 644 LYS LYS A . n 
A 1 382 ASN 382 645 645 ASN ASN A . n 
A 1 383 TRP 383 646 646 TRP TRP A . n 
A 1 384 LEU 384 647 647 LEU LEU A . n 
A 1 385 VAL 385 648 648 VAL VAL A . n 
A 1 386 ARG 386 649 649 ARG ARG A . n 
A 1 387 VAL 387 650 650 VAL VAL A . n 
A 1 388 GLY 388 651 651 GLY GLY A . n 
A 1 389 ARG 389 652 652 ARG ARG A . n 
A 1 390 GLU 390 653 653 GLU GLU A . n 
A 1 391 ARG 391 654 654 ARG ARG A . n 
A 1 392 LEU 392 655 655 LEU LEU A . n 
A 1 393 SER 393 656 656 SER SER A . n 
A 1 394 ARG 394 657 657 ARG ARG A . n 
A 1 395 MET 395 658 658 MET MET A . n 
A 1 396 ALA 396 659 659 ALA ALA A . n 
A 1 397 ILE 397 660 660 ILE ILE A . n 
A 1 398 SER 398 661 661 SER SER A . n 
A 1 399 GLY 399 662 662 GLY GLY A . n 
A 1 400 ASP 400 663 663 ASP ASP A . n 
A 1 401 ASP 401 664 664 ASP ASP A . n 
A 1 402 CYS 402 665 665 CYS CYS A . n 
A 1 403 VAL 403 666 666 VAL VAL A . n 
A 1 404 VAL 404 667 667 VAL VAL A . n 
A 1 405 LYS 405 668 668 LYS LYS A . n 
A 1 406 PRO 406 669 669 PRO PRO A . n 
A 1 407 LEU 407 670 670 LEU LEU A . n 
A 1 408 ASP 408 671 671 ASP ASP A . n 
A 1 409 ASP 409 672 672 ASP ASP A . n 
A 1 410 ARG 410 673 673 ARG ARG A . n 
A 1 411 PHE 411 674 674 PHE PHE A . n 
A 1 412 ALA 412 675 675 ALA ALA A . n 
A 1 413 SER 413 676 676 SER SER A . n 
A 1 414 ALA 414 677 677 ALA ALA A . n 
A 1 415 LEU 415 678 678 LEU LEU A . n 
A 1 416 THR 416 679 679 THR THR A . n 
A 1 417 ALA 417 680 680 ALA ALA A . n 
A 1 418 LEU 418 681 681 LEU LEU A . n 
A 1 419 ASN 419 682 682 ASN ASN A . n 
A 1 420 ASP 420 683 683 ASP ASP A . n 
A 1 421 MET 421 684 684 MET MET A . n 
A 1 422 GLY 422 685 685 GLY GLY A . n 
A 1 423 LYS 423 686 686 LYS LYS A . n 
A 1 424 VAL 424 687 687 VAL VAL A . n 
A 1 425 ARG 425 688 688 ARG ARG A . n 
A 1 426 LYS 426 689 689 LYS LYS A . n 
A 1 427 ASP 427 690 690 ASP ASP A . n 
A 1 428 ILE 428 691 691 ILE ILE A . n 
A 1 429 GLN 429 692 692 GLN GLN A . n 
A 1 430 GLN 430 693 693 GLN GLN A . n 
A 1 431 TRP 431 694 694 TRP TRP A . n 
A 1 432 GLU 432 695 695 GLU GLU A . n 
A 1 433 PRO 433 696 696 PRO PRO A . n 
A 1 434 SER 434 697 697 SER SER A . n 
A 1 435 ARG 435 698 698 ARG ARG A . n 
A 1 436 GLY 436 699 699 GLY GLY A . n 
A 1 437 TRP 437 700 700 TRP TRP A . n 
A 1 438 ASN 438 701 701 ASN ASN A . n 
A 1 439 ASP 439 702 702 ASP ASP A . n 
A 1 440 TRP 440 703 703 TRP TRP A . n 
A 1 441 THR 441 704 704 THR THR A . n 
A 1 442 GLN 442 705 705 GLN GLN A . n 
A 1 443 VAL 443 706 706 VAL VAL A . n 
A 1 444 PRO 444 707 707 PRO PRO A . n 
A 1 445 PHE 445 708 708 PHE PHE A . n 
A 1 446 CYS 446 709 709 CYS CYS A . n 
A 1 447 SER 447 710 710 SER SER A . n 
A 1 448 HIS 448 711 711 HIS HIS A . n 
A 1 449 HIS 449 712 712 HIS HIS A . n 
A 1 450 PHE 450 713 713 PHE PHE A . n 
A 1 451 HIS 451 714 714 HIS HIS A . n 
A 1 452 GLU 452 715 715 GLU GLU A . n 
A 1 453 LEU 453 716 716 LEU LEU A . n 
A 1 454 ILE 454 717 717 ILE ILE A . n 
A 1 455 MET 455 718 718 MET MET A . n 
A 1 456 LYS 456 719 719 LYS LYS A . n 
A 1 457 ASP 457 720 720 ASP ASP A . n 
A 1 458 GLY 458 721 721 GLY GLY A . n 
A 1 459 ARG 459 722 722 ARG ARG A . n 
A 1 460 VAL 460 723 723 VAL VAL A . n 
A 1 461 LEU 461 724 724 LEU LEU A . n 
A 1 462 VAL 462 725 725 VAL VAL A . n 
A 1 463 VAL 463 726 726 VAL VAL A . n 
A 1 464 PRO 464 727 727 PRO PRO A . n 
A 1 465 CYS 465 728 728 CYS CYS A . n 
A 1 466 ARG 466 729 729 ARG ARG A . n 
A 1 467 ASN 467 730 730 ASN ASN A . n 
A 1 468 GLN 468 731 731 GLN GLN A . n 
A 1 469 ASP 469 732 732 ASP ASP A . n 
A 1 470 GLU 470 733 733 GLU GLU A . n 
A 1 471 LEU 471 734 734 LEU LEU A . n 
A 1 472 ILE 472 735 735 ILE ILE A . n 
A 1 473 GLY 473 736 736 GLY GLY A . n 
A 1 474 ARG 474 737 737 ARG ARG A . n 
A 1 475 ALA 475 738 738 ALA ALA A . n 
A 1 476 ARG 476 739 739 ARG ARG A . n 
A 1 477 ILE 477 740 740 ILE ILE A . n 
A 1 478 SER 478 741 741 SER SER A . n 
A 1 479 GLN 479 742 742 GLN GLN A . n 
A 1 480 GLY 480 743 743 GLY GLY A . n 
A 1 481 ALA 481 744 744 ALA ALA A . n 
A 1 482 GLY 482 745 745 GLY GLY A . n 
A 1 483 TRP 483 746 746 TRP TRP A . n 
A 1 484 SER 484 747 747 SER SER A . n 
A 1 485 LEU 485 748 748 LEU LEU A . n 
A 1 486 ARG 486 749 749 ARG ARG A . n 
A 1 487 GLU 487 750 750 GLU GLU A . n 
A 1 488 THR 488 751 751 THR THR A . n 
A 1 489 ALA 489 752 752 ALA ALA A . n 
A 1 490 CYS 490 753 753 CYS CYS A . n 
A 1 491 LEU 491 754 754 LEU LEU A . n 
A 1 492 GLY 492 755 755 GLY GLY A . n 
A 1 493 LYS 493 756 756 LYS LYS A . n 
A 1 494 SER 494 757 757 SER SER A . n 
A 1 495 TYR 495 758 758 TYR TYR A . n 
A 1 496 ALA 496 759 759 ALA ALA A . n 
A 1 497 GLN 497 760 760 GLN GLN A . n 
A 1 498 MET 498 761 761 MET MET A . n 
A 1 499 TRP 499 762 762 TRP TRP A . n 
A 1 500 SER 500 763 763 SER SER A . n 
A 1 501 LEU 501 764 764 LEU LEU A . n 
A 1 502 MET 502 765 765 MET MET A . n 
A 1 503 TYR 503 766 766 TYR TYR A . n 
A 1 504 PHE 504 767 767 PHE PHE A . n 
A 1 505 HIS 505 768 768 HIS HIS A . n 
A 1 506 ARG 506 769 769 ARG ARG A . n 
A 1 507 ARG 507 770 770 ARG ARG A . n 
A 1 508 ASP 508 771 771 ASP ASP A . n 
A 1 509 LEU 509 772 772 LEU LEU A . n 
A 1 510 ARG 510 773 773 ARG ARG A . n 
A 1 511 LEU 511 774 774 LEU LEU A . n 
A 1 512 ALA 512 775 775 ALA ALA A . n 
A 1 513 ALA 513 776 776 ALA ALA A . n 
A 1 514 ASN 514 777 777 ASN ASN A . n 
A 1 515 ALA 515 778 778 ALA ALA A . n 
A 1 516 ILE 516 779 779 ILE ILE A . n 
A 1 517 CYS 517 780 780 CYS CYS A . n 
A 1 518 SER 518 781 781 SER SER A . n 
A 1 519 ALA 519 782 782 ALA ALA A . n 
A 1 520 VAL 520 783 783 VAL VAL A . n 
A 1 521 PRO 521 784 784 PRO PRO A . n 
A 1 522 SER 522 785 785 SER SER A . n 
A 1 523 HIS 523 786 786 HIS HIS A . n 
A 1 524 TRP 524 787 787 TRP TRP A . n 
A 1 525 VAL 525 788 788 VAL VAL A . n 
A 1 526 PRO 526 789 789 PRO PRO A . n 
A 1 527 THR 527 790 790 THR THR A . n 
A 1 528 SER 528 791 791 SER SER A . n 
A 1 529 ARG 529 792 ?   ?   ?   A . n 
A 1 530 THR 530 793 ?   ?   ?   A . n 
A 1 531 THR 531 794 ?   ?   ?   A . n 
A 1 532 TRP 532 795 ?   ?   ?   A . n 
A 1 533 SER 533 796 ?   ?   ?   A . n 
A 1 534 ILE 534 797 ?   ?   ?   A . n 
A 1 535 HIS 535 798 ?   ?   ?   A . n 
A 1 536 ALA 536 799 799 ALA ALA A . n 
A 1 537 THR 537 800 800 THR THR A . n 
A 1 538 HIS 538 801 801 HIS HIS A . n 
A 1 539 GLU 539 802 802 GLU GLU A . n 
A 1 540 TRP 540 803 803 TRP TRP A . n 
A 1 541 MET 541 804 804 MET MET A . n 
A 1 542 THR 542 805 805 THR THR A . n 
A 1 543 THR 543 806 806 THR THR A . n 
A 1 544 GLU 544 807 807 GLU GLU A . n 
A 1 545 ASP 545 808 808 ASP ASP A . n 
A 1 546 MET 546 809 809 MET MET A . n 
A 1 547 LEU 547 810 810 LEU LEU A . n 
A 1 548 THR 548 811 811 THR THR A . n 
A 1 549 VAL 549 812 812 VAL VAL A . n 
A 1 550 TRP 550 813 813 TRP TRP A . n 
A 1 551 ASN 551 814 814 ASN ASN A . n 
A 1 552 ARG 552 815 815 ARG ARG A . n 
A 1 553 VAL 553 816 816 VAL VAL A . n 
A 1 554 TRP 554 817 817 TRP TRP A . n 
A 1 555 ILE 555 818 818 ILE ILE A . n 
A 1 556 GLN 556 819 819 GLN GLN A . n 
A 1 557 GLU 557 820 820 GLU GLU A . n 
A 1 558 ASN 558 821 821 ASN ASN A . n 
A 1 559 PRO 559 822 822 PRO PRO A . n 
A 1 560 TRP 560 823 823 TRP TRP A . n 
A 1 561 MET 561 824 824 MET MET A . n 
A 1 562 GLU 562 825 825 GLU GLU A . n 
A 1 563 ASP 563 826 826 ASP ASP A . n 
A 1 564 LYS 564 827 827 LYS LYS A . n 
A 1 565 THR 565 828 828 THR THR A . n 
A 1 566 PRO 566 829 829 PRO PRO A . n 
A 1 567 VAL 567 830 830 VAL VAL A . n 
A 1 568 GLU 568 831 831 GLU GLU A . n 
A 1 569 SER 569 832 832 SER SER A . n 
A 1 570 TRP 570 833 833 TRP TRP A . n 
A 1 571 GLU 571 834 834 GLU GLU A . n 
A 1 572 GLU 572 835 835 GLU GLU A . n 
A 1 573 ILE 573 836 836 ILE ILE A . n 
A 1 574 PRO 574 837 837 PRO PRO A . n 
A 1 575 TYR 575 838 838 TYR TYR A . n 
A 1 576 LEU 576 839 839 LEU LEU A . n 
A 1 577 GLY 577 840 840 GLY GLY A . n 
A 1 578 LYS 578 841 841 LYS LYS A . n 
A 1 579 ARG 579 842 842 ARG ARG A . n 
A 1 580 GLU 580 843 843 GLU GLU A . n 
A 1 581 ASP 581 844 844 ASP ASP A . n 
A 1 582 GLN 582 845 845 GLN GLN A . n 
A 1 583 TRP 583 846 846 TRP TRP A . n 
A 1 584 CYS 584 847 847 CYS CYS A . n 
A 1 585 GLY 585 848 848 GLY GLY A . n 
A 1 586 SER 586 849 849 SER SER A . n 
A 1 587 LEU 587 850 850 LEU LEU A . n 
A 1 588 ILE 588 851 851 ILE ILE A . n 
A 1 589 GLY 589 852 852 GLY GLY A . n 
A 1 590 LEU 590 853 853 LEU LEU A . n 
A 1 591 THR 591 854 854 THR THR A . n 
A 1 592 SER 592 855 855 SER SER A . n 
A 1 593 ARG 593 856 856 ARG ARG A . n 
A 1 594 ALA 594 857 857 ALA ALA A . n 
A 1 595 THR 595 858 858 THR THR A . n 
A 1 596 TRP 596 859 859 TRP TRP A . n 
A 1 597 ALA 597 860 860 ALA ALA A . n 
A 1 598 LYS 598 861 861 LYS LYS A . n 
A 1 599 ASN 599 862 862 ASN ASN A . n 
A 1 600 ILE 600 863 863 ILE ILE A . n 
A 1 601 GLN 601 864 864 GLN GLN A . n 
A 1 602 THR 602 865 865 THR THR A . n 
A 1 603 ALA 603 866 866 ALA ALA A . n 
A 1 604 ILE 604 867 867 ILE ILE A . n 
A 1 605 ASN 605 868 868 ASN ASN A . n 
A 1 606 GLN 606 869 869 GLN GLN A . n 
A 1 607 VAL 607 870 870 VAL VAL A . n 
A 1 608 ARG 608 871 871 ARG ARG A . n 
A 1 609 SER 609 872 872 SER SER A . n 
A 1 610 LEU 610 873 873 LEU LEU A . n 
A 1 611 ILE 611 874 874 ILE ILE A . n 
A 1 612 GLY 612 875 875 GLY GLY A . n 
A 1 613 ASN 613 876 876 ASN ASN A . n 
A 1 614 GLU 614 877 877 GLU GLU A . n 
A 1 615 GLU 615 878 878 GLU GLU A . n 
A 1 616 TYR 616 879 879 TYR TYR A . n 
A 1 617 THR 617 880 880 THR THR A . n 
A 1 618 ASP 618 881 881 ASP ASP A . n 
A 1 619 TYR 619 882 882 TYR TYR A . n 
A 1 620 MET 620 883 883 MET MET A . n 
A 1 621 PRO 621 884 884 PRO PRO A . n 
A 1 622 SER 622 885 885 SER SER A . n 
A 1 623 MET 623 886 886 MET MET A . n 
A 1 624 LYS 624 887 887 LYS LYS A . n 
A 1 625 ARG 625 888 888 ARG ARG A . n 
A 1 626 PHE 626 889 889 PHE PHE A . n 
A 1 627 ARG 627 890 890 ARG ARG A . n 
A 1 628 ARG 628 891 891 ARG ARG A . n 
A 1 629 GLU 629 892 ?   ?   ?   A . n 
A 1 630 GLU 630 893 ?   ?   ?   A . n 
A 1 631 GLU 631 894 ?   ?   ?   A . n 
A 1 632 GLU 632 895 ?   ?   ?   A . n 
A 1 633 ALA 633 896 ?   ?   ?   A . n 
A 1 634 GLY 634 897 ?   ?   ?   A . n 
A 1 635 VAL 635 898 ?   ?   ?   A . n 
A 1 636 LEU 636 899 ?   ?   ?   A . n 
A 1 637 TRP 637 900 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        JMM 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   JMM 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 ZN  1   1001 1001 ZN  ZN  A . 
C 2 ZN  1   1002 1002 ZN  ZN  A . 
D 3 MES 1   1003 1004 MES MES A . 
E 4 DMS 1   1004 1530 DMS DMS A . 
F 4 DMS 1   1005 1601 DMS DMS A . 
G 5 PO4 1   1006 1604 PO4 PO4 A . 
H 5 PO4 1   1007 1606 PO4 PO4 A . 
I 6 PEG 1   1008 1607 PEG PEG A . 
J 7 CL  1   1009 2001 CL  CL  A . 
K 8 JMM 1   1010 2101 JMM LIG A . 
L 9 HOH 1   1101 90   HOH HOH A . 
L 9 HOH 2   1102 107  HOH HOH A . 
L 9 HOH 3   1103 291  HOH HOH A . 
L 9 HOH 4   1104 76   HOH HOH A . 
L 9 HOH 5   1105 259  HOH HOH A . 
L 9 HOH 6   1106 288  HOH HOH A . 
L 9 HOH 7   1107 341  HOH HOH A . 
L 9 HOH 8   1108 267  HOH HOH A . 
L 9 HOH 9   1109 348  HOH HOH A . 
L 9 HOH 10  1110 175  HOH HOH A . 
L 9 HOH 11  1111 11   HOH HOH A . 
L 9 HOH 12  1112 189  HOH HOH A . 
L 9 HOH 13  1113 35   HOH HOH A . 
L 9 HOH 14  1114 58   HOH HOH A . 
L 9 HOH 15  1115 230  HOH HOH A . 
L 9 HOH 16  1116 136  HOH HOH A . 
L 9 HOH 17  1117 170  HOH HOH A . 
L 9 HOH 18  1118 60   HOH HOH A . 
L 9 HOH 19  1119 254  HOH HOH A . 
L 9 HOH 20  1120 166  HOH HOH A . 
L 9 HOH 21  1121 112  HOH HOH A . 
L 9 HOH 22  1122 108  HOH HOH A . 
L 9 HOH 23  1123 195  HOH HOH A . 
L 9 HOH 24  1124 151  HOH HOH A . 
L 9 HOH 25  1125 460  HOH HOH A . 
L 9 HOH 26  1126 206  HOH HOH A . 
L 9 HOH 27  1127 202  HOH HOH A . 
L 9 HOH 28  1128 209  HOH HOH A . 
L 9 HOH 29  1129 149  HOH HOH A . 
L 9 HOH 30  1130 10   HOH HOH A . 
L 9 HOH 31  1131 16   HOH HOH A . 
L 9 HOH 32  1132 273  HOH HOH A . 
L 9 HOH 33  1133 52   HOH HOH A . 
L 9 HOH 34  1134 180  HOH HOH A . 
L 9 HOH 35  1135 191  HOH HOH A . 
L 9 HOH 36  1136 226  HOH HOH A . 
L 9 HOH 37  1137 152  HOH HOH A . 
L 9 HOH 38  1138 185  HOH HOH A . 
L 9 HOH 39  1139 204  HOH HOH A . 
L 9 HOH 40  1140 197  HOH HOH A . 
L 9 HOH 41  1141 392  HOH HOH A . 
L 9 HOH 42  1142 243  HOH HOH A . 
L 9 HOH 43  1143 187  HOH HOH A . 
L 9 HOH 44  1144 176  HOH HOH A . 
L 9 HOH 45  1145 258  HOH HOH A . 
L 9 HOH 46  1146 178  HOH HOH A . 
L 9 HOH 47  1147 272  HOH HOH A . 
L 9 HOH 48  1148 227  HOH HOH A . 
L 9 HOH 49  1149 280  HOH HOH A . 
L 9 HOH 50  1150 125  HOH HOH A . 
L 9 HOH 51  1151 465  HOH HOH A . 
L 9 HOH 52  1152 25   HOH HOH A . 
L 9 HOH 53  1153 247  HOH HOH A . 
L 9 HOH 54  1154 217  HOH HOH A . 
L 9 HOH 55  1155 215  HOH HOH A . 
L 9 HOH 56  1156 150  HOH HOH A . 
L 9 HOH 57  1157 213  HOH HOH A . 
L 9 HOH 58  1158 251  HOH HOH A . 
L 9 HOH 59  1159 34   HOH HOH A . 
L 9 HOH 60  1160 220  HOH HOH A . 
L 9 HOH 61  1161 292  HOH HOH A . 
L 9 HOH 62  1162 174  HOH HOH A . 
L 9 HOH 63  1163 104  HOH HOH A . 
L 9 HOH 64  1164 408  HOH HOH A . 
L 9 HOH 65  1165 199  HOH HOH A . 
L 9 HOH 66  1166 96   HOH HOH A . 
L 9 HOH 67  1167 177  HOH HOH A . 
L 9 HOH 68  1168 190  HOH HOH A . 
L 9 HOH 69  1169 239  HOH HOH A . 
L 9 HOH 70  1170 222  HOH HOH A . 
L 9 HOH 71  1171 242  HOH HOH A . 
L 9 HOH 72  1172 266  HOH HOH A . 
L 9 HOH 73  1173 216  HOH HOH A . 
L 9 HOH 74  1174 303  HOH HOH A . 
L 9 HOH 75  1175 7    HOH HOH A . 
L 9 HOH 76  1176 201  HOH HOH A . 
L 9 HOH 77  1177 183  HOH HOH A . 
L 9 HOH 78  1178 186  HOH HOH A . 
L 9 HOH 79  1179 466  HOH HOH A . 
L 9 HOH 80  1180 327  HOH HOH A . 
L 9 HOH 81  1181 234  HOH HOH A . 
L 9 HOH 82  1182 192  HOH HOH A . 
L 9 HOH 83  1183 196  HOH HOH A . 
L 9 HOH 84  1184 277  HOH HOH A . 
L 9 HOH 85  1185 249  HOH HOH A . 
L 9 HOH 86  1186 317  HOH HOH A . 
L 9 HOH 87  1187 312  HOH HOH A . 
L 9 HOH 88  1188 240  HOH HOH A . 
L 9 HOH 89  1189 260  HOH HOH A . 
L 9 HOH 90  1190 214  HOH HOH A . 
L 9 HOH 91  1191 19   HOH HOH A . 
L 9 HOH 92  1192 205  HOH HOH A . 
L 9 HOH 93  1193 179  HOH HOH A . 
L 9 HOH 94  1194 245  HOH HOH A . 
L 9 HOH 95  1195 307  HOH HOH A . 
L 9 HOH 96  1196 3    HOH HOH A . 
L 9 HOH 97  1197 293  HOH HOH A . 
L 9 HOH 98  1198 92   HOH HOH A . 
L 9 HOH 99  1199 184  HOH HOH A . 
L 9 HOH 100 1200 5    HOH HOH A . 
L 9 HOH 101 1201 194  HOH HOH A . 
L 9 HOH 102 1202 336  HOH HOH A . 
L 9 HOH 103 1203 210  HOH HOH A . 
L 9 HOH 104 1204 119  HOH HOH A . 
L 9 HOH 105 1205 89   HOH HOH A . 
L 9 HOH 106 1206 244  HOH HOH A . 
L 9 HOH 107 1207 129  HOH HOH A . 
L 9 HOH 108 1208 250  HOH HOH A . 
L 9 HOH 109 1209 188  HOH HOH A . 
L 9 HOH 110 1210 319  HOH HOH A . 
L 9 HOH 111 1211 218  HOH HOH A . 
L 9 HOH 112 1212 2    HOH HOH A . 
L 9 HOH 113 1213 268  HOH HOH A . 
L 9 HOH 114 1214 308  HOH HOH A . 
L 9 HOH 115 1215 323  HOH HOH A . 
L 9 HOH 116 1216 265  HOH HOH A . 
L 9 HOH 117 1217 203  HOH HOH A . 
L 9 HOH 118 1218 252  HOH HOH A . 
L 9 HOH 119 1219 300  HOH HOH A . 
L 9 HOH 120 1220 257  HOH HOH A . 
L 9 HOH 121 1221 256  HOH HOH A . 
L 9 HOH 122 1222 333  HOH HOH A . 
L 9 HOH 123 1223 238  HOH HOH A . 
L 9 HOH 124 1224 69   HOH HOH A . 
L 9 HOH 125 1225 458  HOH HOH A . 
L 9 HOH 126 1226 274  HOH HOH A . 
L 9 HOH 127 1227 346  HOH HOH A . 
L 9 HOH 128 1228 26   HOH HOH A . 
L 9 HOH 129 1229 224  HOH HOH A . 
L 9 HOH 130 1230 345  HOH HOH A . 
L 9 HOH 131 1231 261  HOH HOH A . 
L 9 HOH 132 1232 356  HOH HOH A . 
L 9 HOH 133 1233 289  HOH HOH A . 
L 9 HOH 134 1234 290  HOH HOH A . 
L 9 HOH 135 1235 143  HOH HOH A . 
L 9 HOH 136 1236 264  HOH HOH A . 
L 9 HOH 137 1237 318  HOH HOH A . 
L 9 HOH 138 1238 311  HOH HOH A . 
L 9 HOH 139 1239 6    HOH HOH A . 
L 9 HOH 140 1240 262  HOH HOH A . 
L 9 HOH 141 1241 120  HOH HOH A . 
L 9 HOH 142 1242 45   HOH HOH A . 
L 9 HOH 143 1243 232  HOH HOH A . 
L 9 HOH 144 1244 331  HOH HOH A . 
L 9 HOH 145 1245 281  HOH HOH A . 
L 9 HOH 146 1246 211  HOH HOH A . 
L 9 HOH 147 1247 270  HOH HOH A . 
L 9 HOH 148 1248 66   HOH HOH A . 
L 9 HOH 149 1249 127  HOH HOH A . 
L 9 HOH 150 1250 294  HOH HOH A . 
L 9 HOH 151 1251 145  HOH HOH A . 
L 9 HOH 152 1252 231  HOH HOH A . 
L 9 HOH 153 1253 47   HOH HOH A . 
L 9 HOH 154 1254 225  HOH HOH A . 
L 9 HOH 155 1255 233  HOH HOH A . 
L 9 HOH 156 1256 198  HOH HOH A . 
L 9 HOH 157 1257 296  HOH HOH A . 
L 9 HOH 158 1258 276  HOH HOH A . 
L 9 HOH 159 1259 342  HOH HOH A . 
L 9 HOH 160 1260 287  HOH HOH A . 
L 9 HOH 161 1261 236  HOH HOH A . 
L 9 HOH 162 1262 39   HOH HOH A . 
L 9 HOH 163 1263 315  HOH HOH A . 
L 9 HOH 164 1264 207  HOH HOH A . 
L 9 HOH 165 1265 309  HOH HOH A . 
L 9 HOH 166 1266 321  HOH HOH A . 
L 9 HOH 167 1267 212  HOH HOH A . 
L 9 HOH 168 1268 295  HOH HOH A . 
L 9 HOH 169 1269 29   HOH HOH A . 
L 9 HOH 170 1270 30   HOH HOH A . 
L 9 HOH 171 1271 313  HOH HOH A . 
L 9 HOH 172 1272 182  HOH HOH A . 
L 9 HOH 173 1273 285  HOH HOH A . 
L 9 HOH 174 1274 329  HOH HOH A . 
L 9 HOH 175 1275 4    HOH HOH A . 
L 9 HOH 176 1276 223  HOH HOH A . 
L 9 HOH 177 1277 306  HOH HOH A . 
L 9 HOH 178 1278 320  HOH HOH A . 
L 9 HOH 179 1279 279  HOH HOH A . 
L 9 HOH 180 1280 221  HOH HOH A . 
L 9 HOH 181 1281 304  HOH HOH A . 
L 9 HOH 182 1282 367  HOH HOH A . 
L 9 HOH 183 1283 27   HOH HOH A . 
L 9 HOH 184 1284 322  HOH HOH A . 
L 9 HOH 185 1285 278  HOH HOH A . 
L 9 HOH 186 1286 325  HOH HOH A . 
L 9 HOH 187 1287 219  HOH HOH A . 
L 9 HOH 188 1288 148  HOH HOH A . 
L 9 HOH 189 1289 160  HOH HOH A . 
L 9 HOH 190 1290 235  HOH HOH A . 
L 9 HOH 191 1291 15   HOH HOH A . 
L 9 HOH 192 1292 241  HOH HOH A . 
L 9 HOH 193 1293 368  HOH HOH A . 
L 9 HOH 194 1294 40   HOH HOH A . 
L 9 HOH 195 1295 23   HOH HOH A . 
L 9 HOH 196 1296 298  HOH HOH A . 
L 9 HOH 197 1297 371  HOH HOH A . 
L 9 HOH 198 1298 31   HOH HOH A . 
L 9 HOH 199 1299 355  HOH HOH A . 
L 9 HOH 200 1300 358  HOH HOH A . 
L 9 HOH 201 1301 302  HOH HOH A . 
L 9 HOH 202 1302 328  HOH HOH A . 
L 9 HOH 203 1303 326  HOH HOH A . 
L 9 HOH 204 1304 286  HOH HOH A . 
L 9 HOH 205 1305 193  HOH HOH A . 
L 9 HOH 206 1306 83   HOH HOH A . 
L 9 HOH 207 1307 339  HOH HOH A . 
L 9 HOH 208 1308 255  HOH HOH A . 
L 9 HOH 209 1309 314  HOH HOH A . 
L 9 HOH 210 1310 366  HOH HOH A . 
L 9 HOH 211 1311 48   HOH HOH A . 
L 9 HOH 212 1312 282  HOH HOH A . 
L 9 HOH 213 1313 395  HOH HOH A . 
L 9 HOH 214 1314 70   HOH HOH A . 
L 9 HOH 215 1315 389  HOH HOH A . 
L 9 HOH 216 1316 142  HOH HOH A . 
L 9 HOH 217 1317 330  HOH HOH A . 
L 9 HOH 218 1318 284  HOH HOH A . 
L 9 HOH 219 1319 33   HOH HOH A . 
L 9 HOH 220 1320 396  HOH HOH A . 
L 9 HOH 221 1321 275  HOH HOH A . 
L 9 HOH 222 1322 357  HOH HOH A . 
L 9 HOH 223 1323 360  HOH HOH A . 
L 9 HOH 224 1324 364  HOH HOH A . 
L 9 HOH 225 1325 350  HOH HOH A . 
L 9 HOH 226 1326 334  HOH HOH A . 
L 9 HOH 227 1327 380  HOH HOH A . 
L 9 HOH 228 1328 110  HOH HOH A . 
L 9 HOH 229 1329 316  HOH HOH A . 
L 9 HOH 230 1330 369  HOH HOH A . 
L 9 HOH 231 1331 67   HOH HOH A . 
L 9 HOH 232 1332 361  HOH HOH A . 
L 9 HOH 233 1333 335  HOH HOH A . 
L 9 HOH 234 1334 405  HOH HOH A . 
L 9 HOH 235 1335 391  HOH HOH A . 
L 9 HOH 236 1336 228  HOH HOH A . 
L 9 HOH 237 1337 378  HOH HOH A . 
L 9 HOH 238 1338 347  HOH HOH A . 
L 9 HOH 239 1339 91   HOH HOH A . 
L 9 HOH 240 1340 354  HOH HOH A . 
L 9 HOH 241 1341 32   HOH HOH A . 
L 9 HOH 242 1342 388  HOH HOH A . 
L 9 HOH 243 1343 271  HOH HOH A . 
L 9 HOH 244 1344 263  HOH HOH A . 
L 9 HOH 245 1345 140  HOH HOH A . 
L 9 HOH 246 1346 381  HOH HOH A . 
L 9 HOH 247 1347 310  HOH HOH A . 
L 9 HOH 248 1348 299  HOH HOH A . 
L 9 HOH 249 1349 377  HOH HOH A . 
L 9 HOH 250 1350 305  HOH HOH A . 
L 9 HOH 251 1351 365  HOH HOH A . 
L 9 HOH 252 1352 38   HOH HOH A . 
L 9 HOH 253 1353 400  HOH HOH A . 
L 9 HOH 254 1354 386  HOH HOH A . 
L 9 HOH 255 1355 106  HOH HOH A . 
L 9 HOH 256 1356 208  HOH HOH A . 
L 9 HOH 257 1357 297  HOH HOH A . 
L 9 HOH 258 1358 22   HOH HOH A . 
L 9 HOH 259 1359 14   HOH HOH A . 
L 9 HOH 260 1360 56   HOH HOH A . 
L 9 HOH 261 1361 374  HOH HOH A . 
L 9 HOH 262 1362 353  HOH HOH A . 
L 9 HOH 263 1363 399  HOH HOH A . 
L 9 HOH 264 1364 349  HOH HOH A . 
L 9 HOH 265 1365 114  HOH HOH A . 
L 9 HOH 266 1366 351  HOH HOH A . 
L 9 HOH 267 1367 352  HOH HOH A . 
L 9 HOH 268 1368 340  HOH HOH A . 
L 9 HOH 269 1369 376  HOH HOH A . 
L 9 HOH 270 1370 373  HOH HOH A . 
L 9 HOH 271 1371 384  HOH HOH A . 
L 9 HOH 272 1372 117  HOH HOH A . 
L 9 HOH 273 1373 394  HOH HOH A . 
L 9 HOH 274 1374 459  HOH HOH A . 
L 9 HOH 275 1375 248  HOH HOH A . 
L 9 HOH 276 1376 463  HOH HOH A . 
L 9 HOH 277 1377 375  HOH HOH A . 
L 9 HOH 278 1378 338  HOH HOH A . 
L 9 HOH 279 1379 24   HOH HOH A . 
L 9 HOH 280 1380 344  HOH HOH A . 
L 9 HOH 281 1381 462  HOH HOH A . 
L 9 HOH 282 1382 403  HOH HOH A . 
L 9 HOH 283 1383 383  HOH HOH A . 
L 9 HOH 284 1384 246  HOH HOH A . 
L 9 HOH 285 1385 118  HOH HOH A . 
L 9 HOH 286 1386 402  HOH HOH A . 
L 9 HOH 287 1387 46   HOH HOH A . 
L 9 HOH 288 1388 134  HOH HOH A . 
L 9 HOH 289 1389 398  HOH HOH A . 
L 9 HOH 290 1390 109  HOH HOH A . 
L 9 HOH 291 1391 68   HOH HOH A . 
L 9 HOH 292 1392 387  HOH HOH A . 
L 9 HOH 293 1393 393  HOH HOH A . 
L 9 HOH 294 1394 82   HOH HOH A . 
L 9 HOH 295 1395 379  HOH HOH A . 
L 9 HOH 296 1396 237  HOH HOH A . 
L 9 HOH 297 1397 372  HOH HOH A . 
L 9 HOH 298 1398 406  HOH HOH A . 
L 9 HOH 299 1399 390  HOH HOH A . 
L 9 HOH 300 1400 411  HOH HOH A . 
L 9 HOH 301 1401 18   HOH HOH A . 
L 9 HOH 302 1402 421  HOH HOH A . 
L 9 HOH 303 1403 42   HOH HOH A . 
L 9 HOH 304 1404 138  HOH HOH A . 
L 9 HOH 305 1405 404  HOH HOH A . 
L 9 HOH 306 1406 359  HOH HOH A . 
L 9 HOH 307 1407 418  HOH HOH A . 
L 9 HOH 308 1408 269  HOH HOH A . 
L 9 HOH 309 1409 416  HOH HOH A . 
L 9 HOH 310 1410 1    HOH HOH A . 
L 9 HOH 311 1411 116  HOH HOH A . 
L 9 HOH 312 1412 144  HOH HOH A . 
L 9 HOH 313 1413 100  HOH HOH A . 
L 9 HOH 314 1414 62   HOH HOH A . 
L 9 HOH 315 1415 98   HOH HOH A . 
L 9 HOH 316 1416 80   HOH HOH A . 
L 9 HOH 317 1417 423  HOH HOH A . 
L 9 HOH 318 1418 410  HOH HOH A . 
L 9 HOH 319 1419 99   HOH HOH A . 
L 9 HOH 320 1420 412  HOH HOH A . 
L 9 HOH 321 1421 415  HOH HOH A . 
L 9 HOH 322 1422 417  HOH HOH A . 
L 9 HOH 323 1423 332  HOH HOH A . 
L 9 HOH 324 1424 137  HOH HOH A . 
L 9 HOH 325 1425 422  HOH HOH A . 
L 9 HOH 326 1426 13   HOH HOH A . 
L 9 HOH 327 1427 324  HOH HOH A . 
L 9 HOH 328 1428 20   HOH HOH A . 
L 9 HOH 329 1429 363  HOH HOH A . 
L 9 HOH 330 1430 28   HOH HOH A . 
L 9 HOH 331 1431 467  HOH HOH A . 
L 9 HOH 332 1432 253  HOH HOH A . 
L 9 HOH 333 1433 63   HOH HOH A . 
L 9 HOH 334 1434 132  HOH HOH A . 
L 9 HOH 335 1435 385  HOH HOH A . 
L 9 HOH 336 1436 382  HOH HOH A . 
L 9 HOH 337 1437 159  HOH HOH A . 
L 9 HOH 338 1438 41   HOH HOH A . 
L 9 HOH 339 1439 419  HOH HOH A . 
L 9 HOH 340 1440 97   HOH HOH A . 
L 9 HOH 341 1441 454  HOH HOH A . 
L 9 HOH 342 1442 163  HOH HOH A . 
L 9 HOH 343 1443 424  HOH HOH A . 
L 9 HOH 344 1444 409  HOH HOH A . 
L 9 HOH 345 1445 111  HOH HOH A . 
L 9 HOH 346 1446 12   HOH HOH A . 
L 9 HOH 347 1447 75   HOH HOH A . 
L 9 HOH 348 1448 397  HOH HOH A . 
L 9 HOH 349 1449 431  HOH HOH A . 
L 9 HOH 350 1450 429  HOH HOH A . 
L 9 HOH 351 1451 43   HOH HOH A . 
L 9 HOH 352 1452 54   HOH HOH A . 
L 9 HOH 353 1453 414  HOH HOH A . 
L 9 HOH 354 1454 444  HOH HOH A . 
L 9 HOH 355 1455 430  HOH HOH A . 
L 9 HOH 356 1456 439  HOH HOH A . 
L 9 HOH 357 1457 428  HOH HOH A . 
L 9 HOH 358 1458 464  HOH HOH A . 
L 9 HOH 359 1459 425  HOH HOH A . 
L 9 HOH 360 1460 59   HOH HOH A . 
L 9 HOH 361 1461 72   HOH HOH A . 
L 9 HOH 362 1462 434  HOH HOH A . 
L 9 HOH 363 1463 61   HOH HOH A . 
L 9 HOH 364 1464 157  HOH HOH A . 
L 9 HOH 365 1465 407  HOH HOH A . 
L 9 HOH 366 1466 94   HOH HOH A . 
L 9 HOH 367 1467 426  HOH HOH A . 
L 9 HOH 368 1468 427  HOH HOH A . 
L 9 HOH 369 1469 124  HOH HOH A . 
L 9 HOH 370 1470 51   HOH HOH A . 
L 9 HOH 371 1471 437  HOH HOH A . 
L 9 HOH 372 1472 53   HOH HOH A . 
L 9 HOH 373 1473 123  HOH HOH A . 
L 9 HOH 374 1474 461  HOH HOH A . 
L 9 HOH 375 1475 432  HOH HOH A . 
L 9 HOH 376 1476 435  HOH HOH A . 
L 9 HOH 377 1477 456  HOH HOH A . 
L 9 HOH 378 1478 438  HOH HOH A . 
L 9 HOH 379 1479 436  HOH HOH A . 
L 9 HOH 380 1480 88   HOH HOH A . 
L 9 HOH 381 1481 122  HOH HOH A . 
L 9 HOH 382 1482 126  HOH HOH A . 
L 9 HOH 383 1483 451  HOH HOH A . 
L 9 HOH 384 1484 141  HOH HOH A . 
L 9 HOH 385 1485 446  HOH HOH A . 
L 9 HOH 386 1486 121  HOH HOH A . 
L 9 HOH 387 1487 442  HOH HOH A . 
L 9 HOH 388 1488 115  HOH HOH A . 
L 9 HOH 389 1489 301  HOH HOH A . 
L 9 HOH 390 1490 200  HOH HOH A . 
L 9 HOH 391 1491 445  HOH HOH A . 
L 9 HOH 392 1492 433  HOH HOH A . 
L 9 HOH 393 1493 8    HOH HOH A . 
L 9 HOH 394 1494 64   HOH HOH A . 
L 9 HOH 395 1495 78   HOH HOH A . 
L 9 HOH 396 1496 74   HOH HOH A . 
L 9 HOH 397 1497 449  HOH HOH A . 
L 9 HOH 398 1498 441  HOH HOH A . 
L 9 HOH 399 1499 420  HOH HOH A . 
L 9 HOH 400 1500 135  HOH HOH A . 
L 9 HOH 401 1501 447  HOH HOH A . 
L 9 HOH 402 1502 448  HOH HOH A . 
L 9 HOH 403 1503 9    HOH HOH A . 
L 9 HOH 404 1504 49   HOH HOH A . 
L 9 HOH 405 1505 171  HOH HOH A . 
L 9 HOH 406 1506 95   HOH HOH A . 
L 9 HOH 407 1507 17   HOH HOH A . 
L 9 HOH 408 1508 443  HOH HOH A . 
L 9 HOH 409 1509 450  HOH HOH A . 
L 9 HOH 410 1510 73   HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A THR 344 ? CB  ? A THR 81 CB  
2 1 Y 1 A THR 344 ? OG1 ? A THR 81 OG1 
3 1 Y 1 A THR 344 ? CG2 ? A THR 81 CG2 
# 
loop_
_software.classification 
_software.name 
_software.version 
_software.citation_id 
_software.pdbx_ordinal 
_software.date 
_software.type 
_software.location 
_software.language 
refinement       REFMAC  5.8.0267 ? 1 ? ? ? ? 
'data scaling'   Aimless .        ? 2 ? ? ? ? 
phasing          PHASER  .        ? 3 ? ? ? ? 
'data reduction' XDS     .        ? 4 ? ? ? ? 
# 
_cell.entry_id           7I2T 
_cell.length_a           82.338 
_cell.length_b           116.214 
_cell.length_c           148.020 
_cell.angle_alpha        90.00 
_cell.angle_beta         90.00 
_cell.angle_gamma        90.00 
_cell.Z_PDB              8 
_cell.pdbx_unique_axis   ? 
# 
_symmetry.entry_id                         7I2T 
_symmetry.space_group_name_H-M             'I 2 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                23 
# 
_exptl.entry_id          7I2T 
_exptl.method            'X-RAY DIFFRACTION' 
_exptl.crystals_number   1 
# 
_exptl_crystal.id                    1 
_exptl_crystal.density_meas          ? 
_exptl_crystal.density_Matthews      2.40 
_exptl_crystal.density_percent_sol   48.67 
_exptl_crystal.description           ? 
_exptl_crystal.preparation           ? 
# 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.temp            293.15 
_exptl_crystal_grow.pdbx_details    '350 mM Magnesium chloride, 10% PEG 4000, 100 mM MES, pH 6.5' 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.pdbx_pH_range   ? 
# 
_diffrn.id                               1 
_diffrn.ambient_temp                     100 
_diffrn.crystal_id                       1 
_diffrn.ambient_temp_details             ? 
_diffrn.pdbx_serial_crystal_experiment   ? 
# 
_diffrn_detector.detector               PIXEL 
_diffrn_detector.type                   'DECTRIS EIGER2 XE 9M' 
_diffrn_detector.pdbx_collection_date   2023-12-05 
_diffrn_detector.diffrn_id              1 
_diffrn_detector.details                ? 
# 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.92124 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.diffrn_id                   1 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.type                        'DIAMOND BEAMLINE I04-1' 
_diffrn_source.pdbx_wavelength_list        0.92124 
_diffrn_source.pdbx_synchrotron_site       Diamond 
_diffrn_source.pdbx_synchrotron_beamline   I04-1 
_diffrn_source.pdbx_wavelength             ? 
# 
_reflns.entry_id                     7I2T 
_reflns.pdbx_diffrn_id               1 
_reflns.pdbx_ordinal                 1 
_reflns.d_resolution_low             58.11 
_reflns.d_resolution_high            1.59 
_reflns.number_obs                   95224 
_reflns.percent_possible_obs         100.0 
_reflns.pdbx_Rmerge_I_obs            0.123 
_reflns.pdbx_netI_over_sigmaI        10.5 
_reflns.pdbx_redundancy              12.9 
_reflns.pdbx_Rrim_I_all              0.128 
_reflns.pdbx_Rpim_I_all              0.035 
_reflns.pdbx_CC_half                 0.999 
_reflns.pdbx_number_measured_all     1228663 
_reflns.pdbx_chi_squared             0.43 
_reflns.observed_criterion_sigma_I   ? 
_reflns.observed_criterion_sigma_F   ? 
_reflns.number_all                   ? 
_reflns.pdbx_Rsym_value              ? 
_reflns.B_iso_Wilson_estimate        ? 
_reflns.pdbx_CC_star                 ? 
# 
_reflns_shell.pdbx_diffrn_id              1 
_reflns_shell.pdbx_ordinal                1 
_reflns_shell.d_res_high                  1.59 
_reflns_shell.d_res_low                   1.62 
_reflns_shell.number_measured_all         45208 
_reflns_shell.number_unique_obs           4692 
_reflns_shell.Rmerge_I_obs                3.512 
_reflns_shell.pdbx_chi_squared            0.18 
_reflns_shell.pdbx_redundancy             9.6 
_reflns_shell.percent_possible_obs        99.8 
_reflns_shell.pdbx_netI_over_sigmaI_obs   0.3 
_reflns_shell.pdbx_Rrim_I_all             3.710 
_reflns_shell.pdbx_Rpim_I_all             1.184 
_reflns_shell.pdbx_CC_half                0.370 
_reflns_shell.percent_possible_all        ? 
_reflns_shell.pdbx_Rsym_value             ? 
_reflns_shell.meanI_over_sigI_obs         ? 
_reflns_shell.number_measured_obs         ? 
_reflns_shell.number_unique_all           ? 
_reflns_shell.pdbx_CC_star                ? 
# 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.entry_id                                 7I2T 
_refine.pdbx_diffrn_id                           1 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     89372 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             58.11 
_refine.ls_d_res_high                            1.59 
_refine.ls_percent_reflns_obs                    98.81 
_refine.ls_R_factor_obs                          0.20251 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       0.20112 
_refine.ls_R_factor_R_free                       0.22761 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 5.1 
_refine.ls_number_reflns_R_free                  4790 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               0.966 
_refine.correlation_coeff_Fo_to_Fc_free          0.959 
_refine.B_iso_mean                               50.831 
_refine.aniso_B[1][1]                            -2.18 
_refine.aniso_B[2][2]                            0.23 
_refine.aniso_B[3][3]                            1.95 
_refine.aniso_B[1][2]                            -0.00 
_refine.aniso_B[1][3]                            0.00 
_refine.aniso_B[2][3]                            -0.00 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_overall_ESU_R                       0.113 
_refine.pdbx_overall_ESU_R_Free                  0.105 
_refine.overall_SU_ML                            0.139 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             4.803 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.pdbx_number_atoms_protein        4644 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         58 
_refine_hist.number_atoms_solvent             410 
_refine_hist.number_atoms_total               5112 
_refine_hist.d_res_high                       1.59 
_refine_hist.d_res_low                        58.11 
# 
loop_
_refine_ls_restr.type 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.weight 
_refine_ls_restr.number 
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.pdbx_restraint_function 
r_bond_refined_d             0.008  0.014  ? 8577  'X-RAY DIFFRACTION' ? 
r_bond_other_d               0.001  0.015  ? 6527  'X-RAY DIFFRACTION' ? 
r_angle_refined_deg          1.497  1.647  ? 9443  'X-RAY DIFFRACTION' ? 
r_angle_other_deg            1.270  1.599  ? 15106 'X-RAY DIFFRACTION' ? 
r_dihedral_angle_1_deg       6.135  5.000  ? 884   'X-RAY DIFFRACTION' ? 
r_dihedral_angle_2_deg       30.627 20.693 ? 404   'X-RAY DIFFRACTION' ? 
r_dihedral_angle_3_deg       15.831 15.000 ? 1285  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_4_deg       16.957 15.000 ? 72    'X-RAY DIFFRACTION' ? 
r_chiral_restr               0.071  0.200  ? 850   'X-RAY DIFFRACTION' ? 
r_gen_planes_refined         0.008  0.020  ? 8195  'X-RAY DIFFRACTION' ? 
r_gen_planes_other           0.001  0.020  ? 1741  'X-RAY DIFFRACTION' ? 
r_nbd_refined                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbd_other                  ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_refined              ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_other                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_refined        ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_other          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_refined          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_other            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_refined       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_other         ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_refined     ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_other       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_refined ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_other   ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_mcbond_it                  2.924  5.055  ? 4155  'X-RAY DIFFRACTION' ? 
r_mcbond_other               2.942  5.060  ? 4073  'X-RAY DIFFRACTION' ? 
r_mcangle_it                 4.873  7.226  ? 4274  'X-RAY DIFFRACTION' ? 
r_mcangle_other              4.872  7.226  ? 4275  'X-RAY DIFFRACTION' ? 
r_scbond_it                  3.498  5.893  ? 4422  'X-RAY DIFFRACTION' ? 
r_scbond_other               3.498  5.893  ? 4423  'X-RAY DIFFRACTION' ? 
r_scangle_it                 ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_scangle_other              5.808  8.278  ? 5164  'X-RAY DIFFRACTION' ? 
r_long_range_B_refined       12.495 46.390 ? 7324  'X-RAY DIFFRACTION' ? 
r_long_range_B_other         12.475 46.090 ? 7223  'X-RAY DIFFRACTION' ? 
r_rigid_bond_restr           ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_free            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_bonded          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.d_res_high                       1.590 
_refine_ls_shell.d_res_low                        1.632 
_refine_ls_shell.number_reflns_R_work             5794 
_refine_ls_shell.R_factor_R_work                  0.464 
_refine_ls_shell.percent_reflns_obs               87.07 
_refine_ls_shell.R_factor_R_free                  0.466 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.number_reflns_R_free             301 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.number_reflns_obs                ? 
# 
_struct.entry_id                  7I2T 
_struct.title                     
;Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z32327641 (DNV2_NS5A-x0781)
;
_struct.pdbx_model_details        ? 
_struct.pdbx_CASP_flag            ? 
_struct.pdbx_model_type_details   ? 
# 
_struct_keywords.entry_id        7I2T 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
_struct_keywords.text            
;Diamond Light Source, I04-1, READDI, Dengue Virus, crystallographic fragment screening, PanDDA, XChemExplorer, cluster4x, VIRAL PROTEIN
;
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 5 ? 
H N N 5 ? 
I N N 6 ? 
J N N 7 ? 
K N N 8 ? 
L N N 9 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q91H74_9FLAV 
_struct_ref.pdbx_db_accession          Q91H74 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;GIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAMTD
TTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAREA
VEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLS
GVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRPTP
RGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGDDC
VVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQGAG
WSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPWME
DKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_struct_ref.pdbx_align_begin           2757 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              7I2T 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 3 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 637 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q91H74 
_struct_ref_seq.db_align_beg                  2757 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3391 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       266 
_struct_ref_seq.pdbx_auth_seq_align_end       900 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 7I2T GLY A 1 ? UNP Q91H74 ? ? 'expression tag' 264 1 
1 7I2T PRO A 2 ? UNP Q91H74 ? ? 'expression tag' 265 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 10  ? HIS A 25  ? ASN A 273 HIS A 288 1 ? 16 
HELX_P HELX_P2  AA2 ASN A 59  ? LEU A 65  ? ASN A 322 LEU A 328 1 ? 7  
HELX_P HELX_P3  AA3 THR A 66  ? ILE A 71  ? THR A 329 ILE A 334 5 ? 6  
HELX_P HELX_P4  AA4 ILE A 72  ? GLN A 77  ? ILE A 335 GLN A 340 1 ? 6  
HELX_P HELX_P5  AA5 MET A 78  ? MET A 80  ? MET A 341 MET A 343 5 ? 3  
HELX_P HELX_P6  AA6 LYS A 104 ? LYS A 124 ? LYS A 367 LYS A 387 1 ? 21 
HELX_P HELX_P7  AA7 THR A 132 ? ARG A 141 ? THR A 395 ARG A 404 1 ? 10 
HELX_P HELX_P8  AA8 SER A 158 ? ASP A 165 ? SER A 421 ASP A 428 1 ? 8  
HELX_P HELX_P9  AA9 ASP A 165 ? GLU A 181 ? ASP A 428 GLU A 444 1 ? 17 
HELX_P HELX_P10 AB1 TRP A 215 ? GLY A 227 ? TRP A 478 GLY A 490 1 ? 13 
HELX_P HELX_P11 AB2 GLY A 227 ? ASP A 232 ? GLY A 490 ASP A 495 1 ? 6  
HELX_P HELX_P12 AB3 SER A 236 ? LEU A 241 ? SER A 499 LEU A 504 1 ? 6  
HELX_P HELX_P13 AB4 GLY A 248 ? LYS A 261 ? GLY A 511 LYS A 524 1 ? 14 
HELX_P HELX_P14 AB5 GLY A 274 ? ILE A 279 ? GLY A 537 ILE A 542 5 ? 6  
HELX_P HELX_P15 AB6 THR A 280 ? MET A 289 ? THR A 543 MET A 552 1 ? 10 
HELX_P HELX_P16 AB7 VAL A 290 ? MET A 294 ? VAL A 553 MET A 557 5 ? 5  
HELX_P HELX_P17 AB8 GLU A 295 ? TYR A 310 ? GLU A 558 TYR A 573 1 ? 16 
HELX_P HELX_P18 AB9 GLY A 339 ? GLU A 363 ? GLY A 602 GLU A 626 1 ? 25 
HELX_P HELX_P19 AC1 THR A 373 ? SER A 393 ? THR A 636 SER A 656 1 ? 21 
HELX_P HELX_P20 AC2 ASP A 408 ? ALA A 414 ? ASP A 671 ALA A 677 5 ? 7  
HELX_P HELX_P21 AC3 LEU A 415 ? MET A 421 ? LEU A 678 MET A 684 1 ? 7  
HELX_P HELX_P22 AC4 ASP A 439 ? VAL A 443 ? ASP A 702 VAL A 706 5 ? 5  
HELX_P HELX_P23 AC5 ASN A 467 ? ARG A 476 ? ASN A 730 ARG A 739 1 ? 10 
HELX_P HELX_P24 AC6 SER A 484 ? TYR A 503 ? SER A 747 TYR A 766 1 ? 20 
HELX_P HELX_P25 AC7 ARG A 506 ? VAL A 520 ? ARG A 769 VAL A 783 1 ? 15 
HELX_P HELX_P26 AC8 ASP A 545 ? ILE A 555 ? ASP A 808 ILE A 818 1 ? 11 
HELX_P HELX_P27 AC9 SER A 569 ? ILE A 573 ? SER A 832 ILE A 836 5 ? 5  
HELX_P HELX_P28 AD1 GLY A 577 ? CYS A 584 ? GLY A 840 CYS A 847 1 ? 8  
HELX_P HELX_P29 AD2 LEU A 590 ? ASN A 599 ? LEU A 853 ASN A 862 1 ? 10 
HELX_P HELX_P30 AD3 ASN A 599 ? GLY A 612 ? ASN A 862 GLY A 875 1 ? 14 
HELX_P HELX_P31 AD4 TYR A 619 ? ARG A 627 ? TYR A 882 ARG A 890 5 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A GLU 175 OE1 ? ? ? 1_555 C ZN . ZN ? ? A GLU 438 A ZN 1002 1_555 ? ? ? ? ? ? ? 1.970 ? ? 
metalc2 metalc ? ? A HIS 179 NE2 ? ? ? 1_555 C ZN . ZN ? ? A HIS 442 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.052 ? ? 
metalc3 metalc ? ? A CYS 184 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 447 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.196 ? ? 
metalc4 metalc ? ? A CYS 187 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 450 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.201 ? ? 
metalc5 metalc ? ? A HIS 449 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 712 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.151 ? ? 
metalc6 metalc ? ? A HIS 451 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 714 A ZN 1001 1_555 ? ? ? ? ? ? ? 1.971 ? ? 
metalc7 metalc ? ? A CYS 465 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 728 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.337 ? ? 
metalc8 metalc ? ? A CYS 584 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 847 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.319 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 NE2 ? A HIS 179 ? A HIS 442 ? 1_555 98.1  ? 
2  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 122.5 ? 
3  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 115.2 ? 
4  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 92.2  ? 
5  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 113.6 ? 
6  SG  ? A CYS 184 ? A CYS 447 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 112.8 ? 
7  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 102.8 ? 
8  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 106.2 ? 
9  NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 106.8 ? 
10 NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 104.2 ? 
11 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 115.8 ? 
12 SG  ? A CYS 465 ? A CYS 728 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 119.3 ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 41  ? GLY A 44  ? ALA A 304 GLY A 307 
AA1 2 VAL A 326 ? ARG A 332 ? VAL A 589 ARG A 595 
AA1 3 LYS A 313 ? ARG A 319 ? LYS A 576 ARG A 582 
AA1 4 TYR A 189 ? ASN A 190 ? TYR A 452 ASN A 453 
AA2 1 SER A 56  ? VAL A 58  ? SER A 319 VAL A 321 
AA2 2 ILE A 477 ? GLN A 479 ? ILE A 740 GLN A 742 
AA3 1 MET A 395 ? SER A 398 ? MET A 658 SER A 661 
AA3 2 ASP A 401 ? VAL A 404 ? ASP A 664 VAL A 667 
AA4 1 HIS A 449 ? ILE A 454 ? HIS A 712 ILE A 717 
AA4 2 VAL A 460 ? CYS A 465 ? VAL A 723 CYS A 728 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ALA A 41  ? N ALA A 304 O SER A 331 ? O SER A 594 
AA1 2 3 O ASP A 328 ? O ASP A 591 N VAL A 317 ? N VAL A 580 
AA1 3 4 O VAL A 314 ? O VAL A 577 N TYR A 189 ? N TYR A 452 
AA2 1 2 N MET A 57  ? N MET A 320 O SER A 478 ? O SER A 741 
AA3 1 2 N SER A 398 ? N SER A 661 O ASP A 401 ? O ASP A 664 
AA4 1 2 N LEU A 453 ? N LEU A 716 O LEU A 461 ? O LEU A 724 
# 
_pdbx_entry_details.entry_id                   7I2T 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 OD1 A ASP 664 ? ? O4 A PO4 1006 ? ? 2.01 
2 1 OD1 A ASP 534 ? ? O4 A PO4 1006 ? ? 2.01 
# 
loop_
_pdbx_validate_symm_contact.id 
_pdbx_validate_symm_contact.PDB_model_num 
_pdbx_validate_symm_contact.auth_atom_id_1 
_pdbx_validate_symm_contact.auth_asym_id_1 
_pdbx_validate_symm_contact.auth_comp_id_1 
_pdbx_validate_symm_contact.auth_seq_id_1 
_pdbx_validate_symm_contact.PDB_ins_code_1 
_pdbx_validate_symm_contact.label_alt_id_1 
_pdbx_validate_symm_contact.site_symmetry_1 
_pdbx_validate_symm_contact.auth_atom_id_2 
_pdbx_validate_symm_contact.auth_asym_id_2 
_pdbx_validate_symm_contact.auth_comp_id_2 
_pdbx_validate_symm_contact.auth_seq_id_2 
_pdbx_validate_symm_contact.PDB_ins_code_2 
_pdbx_validate_symm_contact.label_alt_id_2 
_pdbx_validate_symm_contact.site_symmetry_2 
_pdbx_validate_symm_contact.dist 
1 1 O A HOH 1134 ? ? 1_555 O A HOH 1134 ? ? 2_445 1.69 
2 1 O A HOH 1318 ? ? 1_555 O A HOH 1418 ? ? 2_545 2.10 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 HIS A 288 ? ? -140.35 46.13  
2 1 THR A 290 ? ? -93.29  46.29  
3 1 SER A 291 ? ? -169.63 -25.21 
4 1 GLU A 357 ? ? 78.39   -14.63 
5 1 LEU A 504 ? ? 72.69   -44.45 
6 1 GLN A 598 ? ? 74.65   164.36 
7 1 HIS A 801 ? ? -105.83 70.26  
8 1 ILE A 818 ? ? -119.66 -71.70 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A MES 1003 ? D MES . 
2 1 A HOH 1246 ? L HOH . 
3 1 A HOH 1252 ? L HOH . 
4 1 A HOH 1423 ? L HOH . 
5 1 A HOH 1478 ? L HOH . 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 1508 ? 5.86 . 
2 1 O ? A HOH 1509 ? 5.94 . 
3 1 O ? A HOH 1510 ? 6.01 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 264 ? A GLY 1   
2  1 Y 1 A PRO 265 ? A PRO 2   
3  1 Y 1 A GLY 266 ? A GLY 3   
4  1 Y 1 A ILE 267 ? A ILE 4   
5  1 Y 1 A GLU 268 ? A GLU 5   
6  1 Y 1 A SER 269 ? A SER 6   
7  1 Y 1 A GLU 270 ? A GLU 7   
8  1 Y 1 A THR 271 ? A THR 8   
9  1 Y 1 A PRO 272 ? A PRO 9   
10 1 Y 1 A LYS 312 ? A LYS 49  
11 1 Y 1 A GLN 313 ? A GLN 50  
12 1 Y 1 A THR 314 ? A THR 51  
13 1 Y 1 A GLY 315 ? A GLY 52  
14 1 Y 1 A SER 316 ? A SER 53  
15 1 Y 1 A ASP 345 ? A ASP 82  
16 1 Y 1 A THR 346 ? A THR 83  
17 1 Y 1 A THR 347 ? A THR 84  
18 1 Y 1 A PRO 348 ? A PRO 85  
19 1 Y 1 A PHE 349 ? A PHE 86  
20 1 Y 1 A GLY 350 ? A GLY 87  
21 1 Y 1 A GLN 351 ? A GLN 88  
22 1 Y 1 A GLN 352 ? A GLN 89  
23 1 Y 1 A ARG 353 ? A ARG 90  
24 1 Y 1 A VAL 354 ? A VAL 91  
25 1 Y 1 A PHE 355 ? A PHE 92  
26 1 Y 1 A ALA 407 ? A ALA 144 
27 1 Y 1 A ALA 408 ? A ALA 145 
28 1 Y 1 A LEU 409 ? A LEU 146 
29 1 Y 1 A GLY 410 ? A GLY 147 
30 1 Y 1 A ALA 411 ? A ALA 148 
31 1 Y 1 A ILE 412 ? A ILE 149 
32 1 Y 1 A PHE 413 ? A PHE 150 
33 1 Y 1 A THR 414 ? A THR 151 
34 1 Y 1 A ASP 415 ? A ASP 152 
35 1 Y 1 A GLU 416 ? A GLU 153 
36 1 Y 1 A ASN 417 ? A ASN 154 
37 1 Y 1 A GLY 456 ? A GLY 193 
38 1 Y 1 A LYS 457 ? A LYS 194 
39 1 Y 1 A ARG 458 ? A ARG 195 
40 1 Y 1 A GLU 459 ? A GLU 196 
41 1 Y 1 A LYS 460 ? A LYS 197 
42 1 Y 1 A LYS 461 ? A LYS 198 
43 1 Y 1 A LEU 462 ? A LEU 199 
44 1 Y 1 A GLY 463 ? A GLY 200 
45 1 Y 1 A GLU 464 ? A GLU 201 
46 1 Y 1 A PHE 465 ? A PHE 202 
47 1 Y 1 A GLY 466 ? A GLY 203 
48 1 Y 1 A LYS 467 ? A LYS 204 
49 1 Y 1 A ALA 468 ? A ALA 205 
50 1 Y 1 A LYS 469 ? A LYS 206 
51 1 Y 1 A GLY 470 ? A GLY 207 
52 1 Y 1 A PRO 585 ? A PRO 322 
53 1 Y 1 A ARG 586 ? A ARG 323 
54 1 Y 1 A GLY 587 ? A GLY 324 
55 1 Y 1 A ARG 792 ? A ARG 529 
56 1 Y 1 A THR 793 ? A THR 530 
57 1 Y 1 A THR 794 ? A THR 531 
58 1 Y 1 A TRP 795 ? A TRP 532 
59 1 Y 1 A SER 796 ? A SER 533 
60 1 Y 1 A ILE 797 ? A ILE 534 
61 1 Y 1 A HIS 798 ? A HIS 535 
62 1 Y 1 A GLU 892 ? A GLU 629 
63 1 Y 1 A GLU 893 ? A GLU 630 
64 1 Y 1 A GLU 894 ? A GLU 631 
65 1 Y 1 A GLU 895 ? A GLU 632 
66 1 Y 1 A ALA 896 ? A ALA 633 
67 1 Y 1 A GLY 897 ? A GLY 634 
68 1 Y 1 A VAL 898 ? A VAL 635 
69 1 Y 1 A LEU 899 ? A LEU 636 
70 1 Y 1 A TRP 900 ? A TRP 637 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CL  CL   CL N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
DMS S    S  N N 89  
DMS O    O  N N 90  
DMS C1   C  N N 91  
DMS C2   C  N N 92  
DMS H11  H  N N 93  
DMS H12  H  N N 94  
DMS H13  H  N N 95  
DMS H21  H  N N 96  
DMS H22  H  N N 97  
DMS H23  H  N N 98  
GLN N    N  N N 99  
GLN CA   C  N S 100 
GLN C    C  N N 101 
GLN O    O  N N 102 
GLN CB   C  N N 103 
GLN CG   C  N N 104 
GLN CD   C  N N 105 
GLN OE1  O  N N 106 
GLN NE2  N  N N 107 
GLN OXT  O  N N 108 
GLN H    H  N N 109 
GLN H2   H  N N 110 
GLN HA   H  N N 111 
GLN HB2  H  N N 112 
GLN HB3  H  N N 113 
GLN HG2  H  N N 114 
GLN HG3  H  N N 115 
GLN HE21 H  N N 116 
GLN HE22 H  N N 117 
GLN HXT  H  N N 118 
GLU N    N  N N 119 
GLU CA   C  N S 120 
GLU C    C  N N 121 
GLU O    O  N N 122 
GLU CB   C  N N 123 
GLU CG   C  N N 124 
GLU CD   C  N N 125 
GLU OE1  O  N N 126 
GLU OE2  O  N N 127 
GLU OXT  O  N N 128 
GLU H    H  N N 129 
GLU H2   H  N N 130 
GLU HA   H  N N 131 
GLU HB2  H  N N 132 
GLU HB3  H  N N 133 
GLU HG2  H  N N 134 
GLU HG3  H  N N 135 
GLU HE2  H  N N 136 
GLU HXT  H  N N 137 
GLY N    N  N N 138 
GLY CA   C  N N 139 
GLY C    C  N N 140 
GLY O    O  N N 141 
GLY OXT  O  N N 142 
GLY H    H  N N 143 
GLY H2   H  N N 144 
GLY HA2  H  N N 145 
GLY HA3  H  N N 146 
GLY HXT  H  N N 147 
HIS N    N  N N 148 
HIS CA   C  N S 149 
HIS C    C  N N 150 
HIS O    O  N N 151 
HIS CB   C  N N 152 
HIS CG   C  Y N 153 
HIS ND1  N  Y N 154 
HIS CD2  C  Y N 155 
HIS CE1  C  Y N 156 
HIS NE2  N  Y N 157 
HIS OXT  O  N N 158 
HIS H    H  N N 159 
HIS H2   H  N N 160 
HIS HA   H  N N 161 
HIS HB2  H  N N 162 
HIS HB3  H  N N 163 
HIS HD1  H  N N 164 
HIS HD2  H  N N 165 
HIS HE1  H  N N 166 
HIS HE2  H  N N 167 
HIS HXT  H  N N 168 
HOH O    O  N N 169 
HOH H1   H  N N 170 
HOH H2   H  N N 171 
ILE N    N  N N 172 
ILE CA   C  N S 173 
ILE C    C  N N 174 
ILE O    O  N N 175 
ILE CB   C  N S 176 
ILE CG1  C  N N 177 
ILE CG2  C  N N 178 
ILE CD1  C  N N 179 
ILE OXT  O  N N 180 
ILE H    H  N N 181 
ILE H2   H  N N 182 
ILE HA   H  N N 183 
ILE HB   H  N N 184 
ILE HG12 H  N N 185 
ILE HG13 H  N N 186 
ILE HG21 H  N N 187 
ILE HG22 H  N N 188 
ILE HG23 H  N N 189 
ILE HD11 H  N N 190 
ILE HD12 H  N N 191 
ILE HD13 H  N N 192 
ILE HXT  H  N N 193 
JMM C10  C  N N 194 
JMM C13  C  N N 195 
JMM C17  C  N N 196 
JMM C01  C  Y N 197 
JMM C02  C  Y N 198 
JMM C03  C  Y N 199 
JMM O04  O  Y N 200 
JMM C05  C  Y N 201 
JMM C06  C  N N 202 
JMM O07  O  N N 203 
JMM N08  N  N N 204 
JMM C09  C  N N 205 
JMM N11  N  N N 206 
JMM C12  C  N N 207 
JMM C14  C  N N 208 
JMM O15  O  N N 209 
JMM C16  C  N N 210 
JMM C18  C  N N 211 
JMM H101 H  N N 212 
JMM H102 H  N N 213 
JMM H131 H  N N 214 
JMM H132 H  N N 215 
JMM H171 H  N N 216 
JMM H172 H  N N 217 
JMM H011 H  N N 218 
JMM H021 H  N N 219 
JMM H051 H  N N 220 
JMM H092 H  N N 221 
JMM H091 H  N N 222 
JMM H122 H  N N 223 
JMM H121 H  N N 224 
JMM H161 H  N N 225 
JMM H181 H  N N 226 
JMM H182 H  N N 227 
LEU N    N  N N 228 
LEU CA   C  N S 229 
LEU C    C  N N 230 
LEU O    O  N N 231 
LEU CB   C  N N 232 
LEU CG   C  N N 233 
LEU CD1  C  N N 234 
LEU CD2  C  N N 235 
LEU OXT  O  N N 236 
LEU H    H  N N 237 
LEU H2   H  N N 238 
LEU HA   H  N N 239 
LEU HB2  H  N N 240 
LEU HB3  H  N N 241 
LEU HG   H  N N 242 
LEU HD11 H  N N 243 
LEU HD12 H  N N 244 
LEU HD13 H  N N 245 
LEU HD21 H  N N 246 
LEU HD22 H  N N 247 
LEU HD23 H  N N 248 
LEU HXT  H  N N 249 
LYS N    N  N N 250 
LYS CA   C  N S 251 
LYS C    C  N N 252 
LYS O    O  N N 253 
LYS CB   C  N N 254 
LYS CG   C  N N 255 
LYS CD   C  N N 256 
LYS CE   C  N N 257 
LYS NZ   N  N N 258 
LYS OXT  O  N N 259 
LYS H    H  N N 260 
LYS H2   H  N N 261 
LYS HA   H  N N 262 
LYS HB2  H  N N 263 
LYS HB3  H  N N 264 
LYS HG2  H  N N 265 
LYS HG3  H  N N 266 
LYS HD2  H  N N 267 
LYS HD3  H  N N 268 
LYS HE2  H  N N 269 
LYS HE3  H  N N 270 
LYS HZ1  H  N N 271 
LYS HZ2  H  N N 272 
LYS HZ3  H  N N 273 
LYS HXT  H  N N 274 
MES O1   O  N N 275 
MES C2   C  N N 276 
MES C3   C  N N 277 
MES N4   N  N N 278 
MES C5   C  N N 279 
MES C6   C  N N 280 
MES C7   C  N N 281 
MES C8   C  N N 282 
MES S    S  N N 283 
MES O1S  O  N N 284 
MES O2S  O  N N 285 
MES O3S  O  N N 286 
MES H21  H  N N 287 
MES H22  H  N N 288 
MES H31  H  N N 289 
MES H32  H  N N 290 
MES HN4  H  N N 291 
MES H51  H  N N 292 
MES H52  H  N N 293 
MES H61  H  N N 294 
MES H62  H  N N 295 
MES H71  H  N N 296 
MES H72  H  N N 297 
MES H81  H  N N 298 
MES H82  H  N N 299 
MET N    N  N N 300 
MET CA   C  N S 301 
MET C    C  N N 302 
MET O    O  N N 303 
MET CB   C  N N 304 
MET CG   C  N N 305 
MET SD   S  N N 306 
MET CE   C  N N 307 
MET OXT  O  N N 308 
MET H    H  N N 309 
MET H2   H  N N 310 
MET HA   H  N N 311 
MET HB2  H  N N 312 
MET HB3  H  N N 313 
MET HG2  H  N N 314 
MET HG3  H  N N 315 
MET HE1  H  N N 316 
MET HE2  H  N N 317 
MET HE3  H  N N 318 
MET HXT  H  N N 319 
PEG C1   C  N N 320 
PEG O1   O  N N 321 
PEG C2   C  N N 322 
PEG O2   O  N N 323 
PEG C3   C  N N 324 
PEG C4   C  N N 325 
PEG O4   O  N N 326 
PEG H11  H  N N 327 
PEG H12  H  N N 328 
PEG HO1  H  N N 329 
PEG H21  H  N N 330 
PEG H22  H  N N 331 
PEG H31  H  N N 332 
PEG H32  H  N N 333 
PEG H41  H  N N 334 
PEG H42  H  N N 335 
PEG HO4  H  N N 336 
PHE N    N  N N 337 
PHE CA   C  N S 338 
PHE C    C  N N 339 
PHE O    O  N N 340 
PHE CB   C  N N 341 
PHE CG   C  Y N 342 
PHE CD1  C  Y N 343 
PHE CD2  C  Y N 344 
PHE CE1  C  Y N 345 
PHE CE2  C  Y N 346 
PHE CZ   C  Y N 347 
PHE OXT  O  N N 348 
PHE H    H  N N 349 
PHE H2   H  N N 350 
PHE HA   H  N N 351 
PHE HB2  H  N N 352 
PHE HB3  H  N N 353 
PHE HD1  H  N N 354 
PHE HD2  H  N N 355 
PHE HE1  H  N N 356 
PHE HE2  H  N N 357 
PHE HZ   H  N N 358 
PHE HXT  H  N N 359 
PO4 P    P  N N 360 
PO4 O1   O  N N 361 
PO4 O2   O  N N 362 
PO4 O3   O  N N 363 
PO4 O4   O  N N 364 
PRO N    N  N N 365 
PRO CA   C  N S 366 
PRO C    C  N N 367 
PRO O    O  N N 368 
PRO CB   C  N N 369 
PRO CG   C  N N 370 
PRO CD   C  N N 371 
PRO OXT  O  N N 372 
PRO H    H  N N 373 
PRO HA   H  N N 374 
PRO HB2  H  N N 375 
PRO HB3  H  N N 376 
PRO HG2  H  N N 377 
PRO HG3  H  N N 378 
PRO HD2  H  N N 379 
PRO HD3  H  N N 380 
PRO HXT  H  N N 381 
SER N    N  N N 382 
SER CA   C  N S 383 
SER C    C  N N 384 
SER O    O  N N 385 
SER CB   C  N N 386 
SER OG   O  N N 387 
SER OXT  O  N N 388 
SER H    H  N N 389 
SER H2   H  N N 390 
SER HA   H  N N 391 
SER HB2  H  N N 392 
SER HB3  H  N N 393 
SER HG   H  N N 394 
SER HXT  H  N N 395 
THR N    N  N N 396 
THR CA   C  N S 397 
THR C    C  N N 398 
THR O    O  N N 399 
THR CB   C  N R 400 
THR OG1  O  N N 401 
THR CG2  C  N N 402 
THR OXT  O  N N 403 
THR H    H  N N 404 
THR H2   H  N N 405 
THR HA   H  N N 406 
THR HB   H  N N 407 
THR HG1  H  N N 408 
THR HG21 H  N N 409 
THR HG22 H  N N 410 
THR HG23 H  N N 411 
THR HXT  H  N N 412 
TRP N    N  N N 413 
TRP CA   C  N S 414 
TRP C    C  N N 415 
TRP O    O  N N 416 
TRP CB   C  N N 417 
TRP CG   C  Y N 418 
TRP CD1  C  Y N 419 
TRP CD2  C  Y N 420 
TRP NE1  N  Y N 421 
TRP CE2  C  Y N 422 
TRP CE3  C  Y N 423 
TRP CZ2  C  Y N 424 
TRP CZ3  C  Y N 425 
TRP CH2  C  Y N 426 
TRP OXT  O  N N 427 
TRP H    H  N N 428 
TRP H2   H  N N 429 
TRP HA   H  N N 430 
TRP HB2  H  N N 431 
TRP HB3  H  N N 432 
TRP HD1  H  N N 433 
TRP HE1  H  N N 434 
TRP HE3  H  N N 435 
TRP HZ2  H  N N 436 
TRP HZ3  H  N N 437 
TRP HH2  H  N N 438 
TRP HXT  H  N N 439 
TYR N    N  N N 440 
TYR CA   C  N S 441 
TYR C    C  N N 442 
TYR O    O  N N 443 
TYR CB   C  N N 444 
TYR CG   C  Y N 445 
TYR CD1  C  Y N 446 
TYR CD2  C  Y N 447 
TYR CE1  C  Y N 448 
TYR CE2  C  Y N 449 
TYR CZ   C  Y N 450 
TYR OH   O  N N 451 
TYR OXT  O  N N 452 
TYR H    H  N N 453 
TYR H2   H  N N 454 
TYR HA   H  N N 455 
TYR HB2  H  N N 456 
TYR HB3  H  N N 457 
TYR HD1  H  N N 458 
TYR HD2  H  N N 459 
TYR HE1  H  N N 460 
TYR HE2  H  N N 461 
TYR HH   H  N N 462 
TYR HXT  H  N N 463 
VAL N    N  N N 464 
VAL CA   C  N S 465 
VAL C    C  N N 466 
VAL O    O  N N 467 
VAL CB   C  N N 468 
VAL CG1  C  N N 469 
VAL CG2  C  N N 470 
VAL OXT  O  N N 471 
VAL H    H  N N 472 
VAL H2   H  N N 473 
VAL HA   H  N N 474 
VAL HB   H  N N 475 
VAL HG11 H  N N 476 
VAL HG12 H  N N 477 
VAL HG13 H  N N 478 
VAL HG21 H  N N 479 
VAL HG22 H  N N 480 
VAL HG23 H  N N 481 
VAL HXT  H  N N 482 
ZN  ZN   ZN N N 483 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
DMS S   O    doub N N 83  
DMS S   C1   sing N N 84  
DMS S   C2   sing N N 85  
DMS C1  H11  sing N N 86  
DMS C1  H12  sing N N 87  
DMS C1  H13  sing N N 88  
DMS C2  H21  sing N N 89  
DMS C2  H22  sing N N 90  
DMS C2  H23  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
HIS N   CA   sing N N 138 
HIS N   H    sing N N 139 
HIS N   H2   sing N N 140 
HIS CA  C    sing N N 141 
HIS CA  CB   sing N N 142 
HIS CA  HA   sing N N 143 
HIS C   O    doub N N 144 
HIS C   OXT  sing N N 145 
HIS CB  CG   sing N N 146 
HIS CB  HB2  sing N N 147 
HIS CB  HB3  sing N N 148 
HIS CG  ND1  sing Y N 149 
HIS CG  CD2  doub Y N 150 
HIS ND1 CE1  doub Y N 151 
HIS ND1 HD1  sing N N 152 
HIS CD2 NE2  sing Y N 153 
HIS CD2 HD2  sing N N 154 
HIS CE1 NE2  sing Y N 155 
HIS CE1 HE1  sing N N 156 
HIS NE2 HE2  sing N N 157 
HIS OXT HXT  sing N N 158 
HOH O   H1   sing N N 159 
HOH O   H2   sing N N 160 
ILE N   CA   sing N N 161 
ILE N   H    sing N N 162 
ILE N   H2   sing N N 163 
ILE CA  C    sing N N 164 
ILE CA  CB   sing N N 165 
ILE CA  HA   sing N N 166 
ILE C   O    doub N N 167 
ILE C   OXT  sing N N 168 
ILE CB  CG1  sing N N 169 
ILE CB  CG2  sing N N 170 
ILE CB  HB   sing N N 171 
ILE CG1 CD1  sing N N 172 
ILE CG1 HG12 sing N N 173 
ILE CG1 HG13 sing N N 174 
ILE CG2 HG21 sing N N 175 
ILE CG2 HG22 sing N N 176 
ILE CG2 HG23 sing N N 177 
ILE CD1 HD11 sing N N 178 
ILE CD1 HD12 sing N N 179 
ILE CD1 HD13 sing N N 180 
ILE OXT HXT  sing N N 181 
JMM C01 C02  sing Y N 182 
JMM C01 C05  doub Y N 183 
JMM C02 C03  doub Y N 184 
JMM C05 O04  sing Y N 185 
JMM O07 C06  doub N N 186 
JMM C03 C06  sing N N 187 
JMM C03 O04  sing Y N 188 
JMM C06 N08  sing N N 189 
JMM N08 C09  sing N N 190 
JMM N08 C13  sing N N 191 
JMM C09 C10  sing N N 192 
JMM C13 C12  sing N N 193 
JMM C10 N11  sing N N 194 
JMM C12 N11  sing N N 195 
JMM N11 C14  sing N N 196 
JMM C14 O15  doub N N 197 
JMM C14 C16  sing N N 198 
JMM C18 C16  sing N N 199 
JMM C18 C17  sing N N 200 
JMM C16 C17  sing N N 201 
JMM C10 H101 sing N N 202 
JMM C10 H102 sing N N 203 
JMM C13 H131 sing N N 204 
JMM C13 H132 sing N N 205 
JMM C17 H171 sing N N 206 
JMM C17 H172 sing N N 207 
JMM C01 H011 sing N N 208 
JMM C02 H021 sing N N 209 
JMM C05 H051 sing N N 210 
JMM C09 H092 sing N N 211 
JMM C09 H091 sing N N 212 
JMM C12 H122 sing N N 213 
JMM C12 H121 sing N N 214 
JMM C16 H161 sing N N 215 
JMM C18 H181 sing N N 216 
JMM C18 H182 sing N N 217 
LEU N   CA   sing N N 218 
LEU N   H    sing N N 219 
LEU N   H2   sing N N 220 
LEU CA  C    sing N N 221 
LEU CA  CB   sing N N 222 
LEU CA  HA   sing N N 223 
LEU C   O    doub N N 224 
LEU C   OXT  sing N N 225 
LEU CB  CG   sing N N 226 
LEU CB  HB2  sing N N 227 
LEU CB  HB3  sing N N 228 
LEU CG  CD1  sing N N 229 
LEU CG  CD2  sing N N 230 
LEU CG  HG   sing N N 231 
LEU CD1 HD11 sing N N 232 
LEU CD1 HD12 sing N N 233 
LEU CD1 HD13 sing N N 234 
LEU CD2 HD21 sing N N 235 
LEU CD2 HD22 sing N N 236 
LEU CD2 HD23 sing N N 237 
LEU OXT HXT  sing N N 238 
LYS N   CA   sing N N 239 
LYS N   H    sing N N 240 
LYS N   H2   sing N N 241 
LYS CA  C    sing N N 242 
LYS CA  CB   sing N N 243 
LYS CA  HA   sing N N 244 
LYS C   O    doub N N 245 
LYS C   OXT  sing N N 246 
LYS CB  CG   sing N N 247 
LYS CB  HB2  sing N N 248 
LYS CB  HB3  sing N N 249 
LYS CG  CD   sing N N 250 
LYS CG  HG2  sing N N 251 
LYS CG  HG3  sing N N 252 
LYS CD  CE   sing N N 253 
LYS CD  HD2  sing N N 254 
LYS CD  HD3  sing N N 255 
LYS CE  NZ   sing N N 256 
LYS CE  HE2  sing N N 257 
LYS CE  HE3  sing N N 258 
LYS NZ  HZ1  sing N N 259 
LYS NZ  HZ2  sing N N 260 
LYS NZ  HZ3  sing N N 261 
LYS OXT HXT  sing N N 262 
MES O1  C2   sing N N 263 
MES O1  C6   sing N N 264 
MES C2  C3   sing N N 265 
MES C2  H21  sing N N 266 
MES C2  H22  sing N N 267 
MES C3  N4   sing N N 268 
MES C3  H31  sing N N 269 
MES C3  H32  sing N N 270 
MES N4  C5   sing N N 271 
MES N4  C7   sing N N 272 
MES N4  HN4  sing N N 273 
MES C5  C6   sing N N 274 
MES C5  H51  sing N N 275 
MES C5  H52  sing N N 276 
MES C6  H61  sing N N 277 
MES C6  H62  sing N N 278 
MES C7  C8   sing N N 279 
MES C7  H71  sing N N 280 
MES C7  H72  sing N N 281 
MES C8  S    sing N N 282 
MES C8  H81  sing N N 283 
MES C8  H82  sing N N 284 
MES S   O1S  doub N N 285 
MES S   O2S  doub N N 286 
MES S   O3S  sing N N 287 
MET N   CA   sing N N 288 
MET N   H    sing N N 289 
MET N   H2   sing N N 290 
MET CA  C    sing N N 291 
MET CA  CB   sing N N 292 
MET CA  HA   sing N N 293 
MET C   O    doub N N 294 
MET C   OXT  sing N N 295 
MET CB  CG   sing N N 296 
MET CB  HB2  sing N N 297 
MET CB  HB3  sing N N 298 
MET CG  SD   sing N N 299 
MET CG  HG2  sing N N 300 
MET CG  HG3  sing N N 301 
MET SD  CE   sing N N 302 
MET CE  HE1  sing N N 303 
MET CE  HE2  sing N N 304 
MET CE  HE3  sing N N 305 
MET OXT HXT  sing N N 306 
PEG C1  O1   sing N N 307 
PEG C1  C2   sing N N 308 
PEG C1  H11  sing N N 309 
PEG C1  H12  sing N N 310 
PEG O1  HO1  sing N N 311 
PEG C2  O2   sing N N 312 
PEG C2  H21  sing N N 313 
PEG C2  H22  sing N N 314 
PEG O2  C3   sing N N 315 
PEG C3  C4   sing N N 316 
PEG C3  H31  sing N N 317 
PEG C3  H32  sing N N 318 
PEG C4  O4   sing N N 319 
PEG C4  H41  sing N N 320 
PEG C4  H42  sing N N 321 
PEG O4  HO4  sing N N 322 
PHE N   CA   sing N N 323 
PHE N   H    sing N N 324 
PHE N   H2   sing N N 325 
PHE CA  C    sing N N 326 
PHE CA  CB   sing N N 327 
PHE CA  HA   sing N N 328 
PHE C   O    doub N N 329 
PHE C   OXT  sing N N 330 
PHE CB  CG   sing N N 331 
PHE CB  HB2  sing N N 332 
PHE CB  HB3  sing N N 333 
PHE CG  CD1  doub Y N 334 
PHE CG  CD2  sing Y N 335 
PHE CD1 CE1  sing Y N 336 
PHE CD1 HD1  sing N N 337 
PHE CD2 CE2  doub Y N 338 
PHE CD2 HD2  sing N N 339 
PHE CE1 CZ   doub Y N 340 
PHE CE1 HE1  sing N N 341 
PHE CE2 CZ   sing Y N 342 
PHE CE2 HE2  sing N N 343 
PHE CZ  HZ   sing N N 344 
PHE OXT HXT  sing N N 345 
PO4 P   O1   doub N N 346 
PO4 P   O2   sing N N 347 
PO4 P   O3   sing N N 348 
PO4 P   O4   sing N N 349 
PRO N   CA   sing N N 350 
PRO N   CD   sing N N 351 
PRO N   H    sing N N 352 
PRO CA  C    sing N N 353 
PRO CA  CB   sing N N 354 
PRO CA  HA   sing N N 355 
PRO C   O    doub N N 356 
PRO C   OXT  sing N N 357 
PRO CB  CG   sing N N 358 
PRO CB  HB2  sing N N 359 
PRO CB  HB3  sing N N 360 
PRO CG  CD   sing N N 361 
PRO CG  HG2  sing N N 362 
PRO CG  HG3  sing N N 363 
PRO CD  HD2  sing N N 364 
PRO CD  HD3  sing N N 365 
PRO OXT HXT  sing N N 366 
SER N   CA   sing N N 367 
SER N   H    sing N N 368 
SER N   H2   sing N N 369 
SER CA  C    sing N N 370 
SER CA  CB   sing N N 371 
SER CA  HA   sing N N 372 
SER C   O    doub N N 373 
SER C   OXT  sing N N 374 
SER CB  OG   sing N N 375 
SER CB  HB2  sing N N 376 
SER CB  HB3  sing N N 377 
SER OG  HG   sing N N 378 
SER OXT HXT  sing N N 379 
THR N   CA   sing N N 380 
THR N   H    sing N N 381 
THR N   H2   sing N N 382 
THR CA  C    sing N N 383 
THR CA  CB   sing N N 384 
THR CA  HA   sing N N 385 
THR C   O    doub N N 386 
THR C   OXT  sing N N 387 
THR CB  OG1  sing N N 388 
THR CB  CG2  sing N N 389 
THR CB  HB   sing N N 390 
THR OG1 HG1  sing N N 391 
THR CG2 HG21 sing N N 392 
THR CG2 HG22 sing N N 393 
THR CG2 HG23 sing N N 394 
THR OXT HXT  sing N N 395 
TRP N   CA   sing N N 396 
TRP N   H    sing N N 397 
TRP N   H2   sing N N 398 
TRP CA  C    sing N N 399 
TRP CA  CB   sing N N 400 
TRP CA  HA   sing N N 401 
TRP C   O    doub N N 402 
TRP C   OXT  sing N N 403 
TRP CB  CG   sing N N 404 
TRP CB  HB2  sing N N 405 
TRP CB  HB3  sing N N 406 
TRP CG  CD1  doub Y N 407 
TRP CG  CD2  sing Y N 408 
TRP CD1 NE1  sing Y N 409 
TRP CD1 HD1  sing N N 410 
TRP CD2 CE2  doub Y N 411 
TRP CD2 CE3  sing Y N 412 
TRP NE1 CE2  sing Y N 413 
TRP NE1 HE1  sing N N 414 
TRP CE2 CZ2  sing Y N 415 
TRP CE3 CZ3  doub Y N 416 
TRP CE3 HE3  sing N N 417 
TRP CZ2 CH2  doub Y N 418 
TRP CZ2 HZ2  sing N N 419 
TRP CZ3 CH2  sing Y N 420 
TRP CZ3 HZ3  sing N N 421 
TRP CH2 HH2  sing N N 422 
TRP OXT HXT  sing N N 423 
TYR N   CA   sing N N 424 
TYR N   H    sing N N 425 
TYR N   H2   sing N N 426 
TYR CA  C    sing N N 427 
TYR CA  CB   sing N N 428 
TYR CA  HA   sing N N 429 
TYR C   O    doub N N 430 
TYR C   OXT  sing N N 431 
TYR CB  CG   sing N N 432 
TYR CB  HB2  sing N N 433 
TYR CB  HB3  sing N N 434 
TYR CG  CD1  doub Y N 435 
TYR CG  CD2  sing Y N 436 
TYR CD1 CE1  sing Y N 437 
TYR CD1 HD1  sing N N 438 
TYR CD2 CE2  doub Y N 439 
TYR CD2 HD2  sing N N 440 
TYR CE1 CZ   doub Y N 441 
TYR CE1 HE1  sing N N 442 
TYR CE2 CZ   sing Y N 443 
TYR CE2 HE2  sing N N 444 
TYR CZ  OH   sing N N 445 
TYR OH  HH   sing N N 446 
TYR OXT HXT  sing N N 447 
VAL N   CA   sing N N 448 
VAL N   H    sing N N 449 
VAL N   H2   sing N N 450 
VAL CA  C    sing N N 451 
VAL CA  CB   sing N N 452 
VAL CA  HA   sing N N 453 
VAL C   O    doub N N 454 
VAL C   OXT  sing N N 455 
VAL CB  CG1  sing N N 456 
VAL CB  CG2  sing N N 457 
VAL CB  HB   sing N N 458 
VAL CG1 HG11 sing N N 459 
VAL CG1 HG12 sing N N 460 
VAL CG1 HG13 sing N N 461 
VAL CG2 HG21 sing N N 462 
VAL CG2 HG22 sing N N 463 
VAL CG2 HG23 sing N N 464 
VAL OXT HXT  sing N N 465 
# 
_pdbx_audit_support.ordinal                1 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)' 
_pdbx_audit_support.grant_number           U19AI171292 
_pdbx_audit_support.country                'United States' 
# 
_pdbx_deposit_group.group_id            G_1002341 
_pdbx_deposit_group.group_description   
'Crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_title         
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_type          'changed state' 
# 
_atom_sites.entry_id                    7I2T 
_atom_sites.fract_transf_matrix[1][1]   0.012145 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.008605 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006756 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
# 
loop_
_atom_type.symbol 
C  
CL 
N  
O  
P  
S  
ZN 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ASN A 1 10  ? -13.484 -5.356  -12.199 1.00 98.52  ? 273  ASN A N   1 
ATOM   2    C  CA  . ASN A 1 10  ? -13.466 -6.613  -11.410 1.00 96.10  ? 273  ASN A CA  1 
ATOM   3    C  C   . ASN A 1 10  ? -14.612 -6.602  -10.402 1.00 96.18  ? 273  ASN A C   1 
ATOM   4    O  O   . ASN A 1 10  ? -15.621 -7.274  -10.668 1.00 84.79  ? 273  ASN A O   1 
ATOM   5    C  CB  . ASN A 1 10  ? -12.127 -6.818  -10.700 1.00 100.97 ? 273  ASN A CB  1 
ATOM   6    C  CG  . ASN A 1 10  ? -12.057 -8.108  -9.912  1.00 99.54  ? 273  ASN A CG  1 
ATOM   7    O  OD1 . ASN A 1 10  ? -12.563 -9.137  -10.353 1.00 106.34 ? 273  ASN A OD1 1 
ATOM   8    N  ND2 . ASN A 1 10  ? -11.417 -8.064  -8.754  1.00 92.51  ? 273  ASN A ND2 1 
ATOM   9    N  N   . LEU A 1 11  ? -14.467 -5.857  -9.298  1.00 92.76  ? 274  LEU A N   1 
ATOM   10   C  CA  . LEU A 1 11  ? -15.494 -5.910  -8.226  1.00 80.45  ? 274  LEU A CA  1 
ATOM   11   C  C   . LEU A 1 11  ? -16.805 -5.328  -8.744  1.00 73.63  ? 274  LEU A C   1 
ATOM   12   O  O   . LEU A 1 11  ? -17.843 -5.580  -8.124  1.00 71.80  ? 274  LEU A O   1 
ATOM   13   C  CB  . LEU A 1 11  ? -14.971 -5.169  -6.995  1.00 89.32  ? 274  LEU A CB  1 
ATOM   14   C  CG  . LEU A 1 11  ? -14.262 -6.054  -5.971  1.00 96.20  ? 274  LEU A CG  1 
ATOM   15   C  CD1 . LEU A 1 11  ? -13.443 -5.220  -5.002  1.00 96.35  ? 274  LEU A CD1 1 
ATOM   16   C  CD2 . LEU A 1 11  ? -15.262 -6.920  -5.222  1.00 95.51  ? 274  LEU A CD2 1 
ATOM   17   N  N   . ASP A 1 12  ? -16.748 -4.596  -9.848  1.00 64.44  ? 275  ASP A N   1 
ATOM   18   C  CA  . ASP A 1 12  ? -18.003 -4.097  -10.455 1.00 77.57  ? 275  ASP A CA  1 
ATOM   19   C  C   . ASP A 1 12  ? -18.803 -5.287  -10.989 1.00 79.06  ? 275  ASP A C   1 
ATOM   20   O  O   . ASP A 1 12  ? -20.030 -5.161  -11.086 1.00 81.62  ? 275  ASP A O   1 
ATOM   21   C  CB  . ASP A 1 12  ? -17.715 -3.076  -11.556 1.00 82.54  ? 275  ASP A CB  1 
ATOM   22   C  CG  . ASP A 1 12  ? -16.599 -3.492  -12.492 1.00 87.69  ? 275  ASP A CG  1 
ATOM   23   O  OD1 . ASP A 1 12  ? -15.591 -4.026  -11.997 1.00 93.08  ? 275  ASP A OD1 1 
ATOM   24   O  OD2 . ASP A 1 12  ? -16.751 -3.278  -13.708 1.00 97.08  ? 275  ASP A OD2 1 
ATOM   25   N  N   . ILE A 1 13  ? -18.128 -6.394  -11.318 1.00 71.87  ? 276  ILE A N   1 
ATOM   26   C  CA  . ILE A 1 13  ? -18.818 -7.570  -11.925 1.00 56.74  ? 276  ILE A CA  1 
ATOM   27   C  C   . ILE A 1 13  ? -19.114 -8.611  -10.844 1.00 51.13  ? 276  ILE A C   1 
ATOM   28   O  O   . ILE A 1 13  ? -20.135 -9.293  -10.960 1.00 49.79  ? 276  ILE A O   1 
ATOM   29   C  CB  . ILE A 1 13  ? -17.954 -8.128  -13.070 1.00 58.55  ? 276  ILE A CB  1 
ATOM   30   C  CG1 . ILE A 1 13  ? -17.812 -7.102  -14.197 1.00 53.84  ? 276  ILE A CG1 1 
ATOM   31   C  CG2 . ILE A 1 13  ? -18.494 -9.457  -13.574 1.00 53.60  ? 276  ILE A CG2 1 
ATOM   32   C  CD1 . ILE A 1 13  ? -16.925 -7.546  -15.331 1.00 51.13  ? 276  ILE A CD1 1 
ATOM   33   N  N   . ILE A 1 14  ? -18.272 -8.686  -9.817  1.00 52.13  ? 277  ILE A N   1 
ATOM   34   C  CA  . ILE A 1 14  ? -18.433 -9.726  -8.762  1.00 61.79  ? 277  ILE A CA  1 
ATOM   35   C  C   . ILE A 1 14  ? -19.003 -9.132  -7.468  1.00 61.50  ? 277  ILE A C   1 
ATOM   36   O  O   . ILE A 1 14  ? -19.479 -9.918  -6.639  1.00 62.03  ? 277  ILE A O   1 
ATOM   37   C  CB  . ILE A 1 14  ? -17.073 -10.409 -8.515  1.00 65.52  ? 277  ILE A CB  1 
ATOM   38   C  CG1 . ILE A 1 14  ? -16.009 -9.410  -8.055  1.00 61.22  ? 277  ILE A CG1 1 
ATOM   39   C  CG2 . ILE A 1 14  ? -16.627 -11.175 -9.750  1.00 62.68  ? 277  ILE A CG2 1 
ATOM   40   C  CD1 . ILE A 1 14  ? -14.679 -10.044 -7.742  1.00 65.52  ? 277  ILE A CD1 1 
ATOM   41   N  N   . GLY A 1 15  ? -18.973 -7.809  -7.298  1.00 74.46  ? 278  GLY A N   1 
ATOM   42   C  CA  . GLY A 1 15  ? -19.404 -7.181  -6.026  1.00 70.10  ? 278  GLY A CA  1 
ATOM   43   C  C   . GLY A 1 15  ? -20.822 -7.522  -5.603  1.00 66.92  ? 278  GLY A C   1 
ATOM   44   O  O   . GLY A 1 15  ? -20.997 -7.945  -4.457  1.00 70.84  ? 278  GLY A O   1 
ATOM   45   N  N   . LYS A 1 16  ? -21.798 -7.367  -6.497  1.00 66.50  ? 279  LYS A N   1 
ATOM   46   C  CA  . LYS A 1 16  ? -23.222 -7.623  -6.170  1.00 61.88  ? 279  LYS A CA  1 
ATOM   47   C  C   . LYS A 1 16  ? -23.387 -9.028  -5.597  1.00 63.98  ? 279  LYS A C   1 
ATOM   48   O  O   . LYS A 1 16  ? -24.075 -9.173  -4.583  1.00 58.74  ? 279  LYS A O   1 
ATOM   49   C  CB  . LYS A 1 16  ? -24.059 -7.427  -7.435  1.00 68.72  ? 279  LYS A CB  1 
ATOM   50   C  CG  . LYS A 1 16  ? -25.560 -7.639  -7.314  1.00 75.16  ? 279  LYS A CG  1 
ATOM   51   C  CD  . LYS A 1 16  ? -26.278 -7.254  -8.591  1.00 78.00  ? 279  LYS A CD  1 
ATOM   52   C  CE  . LYS A 1 16  ? -27.779 -7.428  -8.522  1.00 84.75  ? 279  LYS A CE  1 
ATOM   53   N  NZ  . LYS A 1 16  ? -28.374 -6.634  -7.422  1.00 88.37  ? 279  LYS A NZ  1 
ATOM   54   N  N   . ARG A 1 17  ? -22.778 -10.024 -6.242  1.00 64.19  ? 280  ARG A N   1 
ATOM   55   C  CA  . ARG A 1 17  ? -22.862 -11.418 -5.744  1.00 63.95  ? 280  ARG A CA  1 
ATOM   56   C  C   . ARG A 1 17  ? -22.244 -11.468 -4.351  1.00 61.79  ? 280  ARG A C   1 
ATOM   57   O  O   . ARG A 1 17  ? -22.834 -12.110 -3.472  1.00 62.97  ? 280  ARG A O   1 
ATOM   58   C  CB  . ARG A 1 17  ? -22.127 -12.372 -6.689  1.00 64.11  ? 280  ARG A CB  1 
ATOM   59   C  CG  . ARG A 1 17  ? -22.959 -12.878 -7.858  1.00 62.39  ? 280  ARG A CG  1 
ATOM   60   C  CD  . ARG A 1 17  ? -22.137 -13.633 -8.884  1.00 53.34  ? 280  ARG A CD  1 
ATOM   61   N  NE  . ARG A 1 17  ? -21.472 -12.723 -9.802  1.00 52.86  ? 280  ARG A NE  1 
ATOM   62   C  CZ  . ARG A 1 17  ? -20.701 -13.096 -10.814 1.00 52.52  ? 280  ARG A CZ  1 
ATOM   63   N  NH1 . ARG A 1 17  ? -20.483 -14.378 -11.048 1.00 51.29  ? 280  ARG A NH1 1 
ATOM   64   N  NH2 . ARG A 1 17  ? -20.149 -12.183 -11.591 1.00 48.91  ? 280  ARG A NH2 1 
ATOM   65   N  N   . ILE A 1 18  ? -21.103 -10.803 -4.174  0.50 64.52  ? 281  ILE A N   1 
ATOM   66   C  CA  . ILE A 1 18  ? -20.401 -10.807 -2.859  0.50 65.89  ? 281  ILE A CA  1 
ATOM   67   C  C   . ILE A 1 18  ? -21.293 -10.104 -1.830  0.50 67.31  ? 281  ILE A C   1 
ATOM   68   O  O   . ILE A 1 18  ? -21.452 -10.647 -0.721  0.50 68.58  ? 281  ILE A O   1 
ATOM   69   C  CB  . ILE A 1 18  ? -19.019 -10.141 -2.993  0.50 67.20  ? 281  ILE A CB  1 
ATOM   70   C  CG1 . ILE A 1 18  ? -18.150 -10.861 -4.027  0.50 67.63  ? 281  ILE A CG1 1 
ATOM   71   C  CG2 . ILE A 1 18  ? -18.326 -10.051 -1.643  0.50 66.56  ? 281  ILE A CG2 1 
ATOM   72   C  CD1 . ILE A 1 18  ? -16.846 -10.165 -4.326  0.50 68.22  ? 281  ILE A CD1 1 
ATOM   73   N  N   . GLU A 1 19  ? -21.876 -8.961  -2.201  0.50 67.40  ? 282  GLU A N   1 
ATOM   74   C  CA  . GLU A 1 19  ? -22.726 -8.189  -1.254  0.50 67.64  ? 282  GLU A CA  1 
ATOM   75   C  C   . GLU A 1 19  ? -23.924 -9.042  -0.842  0.50 67.33  ? 282  GLU A C   1 
ATOM   76   O  O   . GLU A 1 19  ? -24.206 -9.112  0.367   0.50 67.24  ? 282  GLU A O   1 
ATOM   77   C  CB  . GLU A 1 19  ? -23.210 -6.891  -1.896  0.50 68.22  ? 282  GLU A CB  1 
ATOM   78   C  CG  . GLU A 1 19  ? -22.089 -5.952  -2.299  0.50 67.23  ? 282  GLU A CG  1 
ATOM   79   C  CD  . GLU A 1 19  ? -22.559 -4.705  -3.028  0.50 67.07  ? 282  GLU A CD  1 
ATOM   80   O  OE1 . GLU A 1 19  ? -23.765 -4.618  -3.331  0.50 67.09  ? 282  GLU A OE1 1 
ATOM   81   O  OE2 . GLU A 1 19  ? -21.719 -3.822  -3.290  0.50 61.13  ? 282  GLU A OE2 1 
ATOM   82   N  N   . LYS A 1 20  ? -24.579 -9.687  -1.810  1.00 68.56  ? 283  LYS A N   1 
ATOM   83   C  CA  . LYS A 1 20  ? -25.801 -10.471 -1.500  1.00 66.00  ? 283  LYS A CA  1 
ATOM   84   C  C   . LYS A 1 20  ? -25.461 -11.558 -0.487  1.00 72.69  ? 283  LYS A C   1 
ATOM   85   O  O   . LYS A 1 20  ? -26.271 -11.776 0.427   1.00 69.46  ? 283  LYS A O   1 
ATOM   86   C  CB  . LYS A 1 20  ? -26.386 -11.113 -2.758  1.00 66.61  ? 283  LYS A CB  1 
ATOM   87   C  CG  . LYS A 1 20  ? -27.607 -11.991 -2.539  1.00 64.91  ? 283  LYS A CG  1 
ATOM   88   C  CD  . LYS A 1 20  ? -28.269 -12.426 -3.826  1.00 71.35  ? 283  LYS A CD  1 
ATOM   89   C  CE  . LYS A 1 20  ? -29.522 -13.246 -3.608  1.00 67.73  ? 283  LYS A CE  1 
ATOM   90   N  NZ  . LYS A 1 20  ? -29.224 -14.559 -2.992  1.00 66.74  ? 283  LYS A NZ  1 
ATOM   91   N  N   . ILE A 1 21  ? -24.314 -12.214 -0.652  1.00 66.45  ? 284  ILE A N   1 
ATOM   92   C  CA  . ILE A 1 21  ? -23.975 -13.354 0.247   1.00 74.32  ? 284  ILE A CA  1 
ATOM   93   C  C   . ILE A 1 21  ? -23.653 -12.821 1.650   1.00 75.43  ? 284  ILE A C   1 
ATOM   94   O  O   . ILE A 1 21  ? -24.094 -13.438 2.631   1.00 69.06  ? 284  ILE A O   1 
ATOM   95   C  CB  . ILE A 1 21  ? -22.818 -14.182 -0.348  1.00 76.71  ? 284  ILE A CB  1 
ATOM   96   C  CG1 . ILE A 1 21  ? -23.181 -14.766 -1.715  1.00 72.63  ? 284  ILE A CG1 1 
ATOM   97   C  CG2 . ILE A 1 21  ? -22.364 -15.259 0.626   1.00 75.25  ? 284  ILE A CG2 1 
ATOM   98   C  CD1 . ILE A 1 21  ? -22.001 -15.321 -2.476  1.00 72.70  ? 284  ILE A CD1 1 
ATOM   99   N  N   . LYS A 1 22  ? -22.933 -11.704 1.730   1.00 76.16  ? 285  LYS A N   1 
ATOM   100  C  CA  . LYS A 1 22  ? -22.550 -11.131 3.045   1.00 84.76  ? 285  LYS A CA  1 
ATOM   101  C  C   . LYS A 1 22  ? -23.815 -10.924 3.874   1.00 81.16  ? 285  LYS A C   1 
ATOM   102  O  O   . LYS A 1 22  ? -23.792 -11.237 5.068   1.00 83.68  ? 285  LYS A O   1 
ATOM   103  C  CB  . LYS A 1 22  ? -21.793 -9.816  2.850   1.00 91.25  ? 285  LYS A CB  1 
ATOM   104  C  CG  . LYS A 1 22  ? -21.605 -8.980  4.107   1.00 95.66  ? 285  LYS A CG  1 
ATOM   105  C  CD  . LYS A 1 22  ? -20.933 -7.649  3.848   1.00 97.04  ? 285  LYS A CD  1 
ATOM   106  C  CE  . LYS A 1 22  ? -20.992 -6.718  5.041   1.00 102.23 ? 285  LYS A CE  1 
ATOM   107  N  NZ  . LYS A 1 22  ? -20.434 -5.382  4.728   1.00 103.46 ? 285  LYS A NZ  1 
ATOM   108  N  N   . GLN A 1 23  ? -24.891 -10.471 3.236   1.00 85.54  ? 286  GLN A N   1 
ATOM   109  C  CA  . GLN A 1 23  ? -26.149 -10.172 3.972   1.00 84.06  ? 286  GLN A CA  1 
ATOM   110  C  C   . GLN A 1 23  ? -26.806 -11.450 4.518   1.00 84.76  ? 286  GLN A C   1 
ATOM   111  O  O   . GLN A 1 23  ? -27.289 -11.396 5.657   1.00 100.25 ? 286  GLN A O   1 
ATOM   112  C  CB  . GLN A 1 23  ? -27.066 -9.349  3.066   1.00 82.54  ? 286  GLN A CB  1 
ATOM   113  C  CG  . GLN A 1 23  ? -26.337 -8.163  2.453   1.00 84.29  ? 286  GLN A CG  1 
ATOM   114  C  CD  . GLN A 1 23  ? -27.241 -7.223  1.697   1.00 85.18  ? 286  GLN A CD  1 
ATOM   115  O  OE1 . GLN A 1 23  ? -28.443 -7.443  1.583   1.00 91.56  ? 286  GLN A OE1 1 
ATOM   116  N  NE2 . GLN A 1 23  ? -26.658 -6.158  1.173   1.00 87.76  ? 286  GLN A NE2 1 
ATOM   117  N  N   . GLU A 1 24  ? -26.848 -12.543 3.758   1.00 78.21  ? 287  GLU A N   1 
ATOM   118  C  CA  . GLU A 1 24  ? -27.562 -13.757 4.240   1.00 85.26  ? 287  GLU A CA  1 
ATOM   119  C  C   . GLU A 1 24  ? -26.767 -14.363 5.400   1.00 91.22  ? 287  GLU A C   1 
ATOM   120  O  O   . GLU A 1 24  ? -27.245 -15.345 5.997   1.00 90.82  ? 287  GLU A O   1 
ATOM   121  C  CB  . GLU A 1 24  ? -27.781 -14.727 3.081   1.00 83.62  ? 287  GLU A CB  1 
ATOM   122  C  CG  . GLU A 1 24  ? -28.498 -14.084 1.911   1.00 90.56  ? 287  GLU A CG  1 
ATOM   123  C  CD  . GLU A 1 24  ? -28.098 -14.608 0.544   1.00 95.81  ? 287  GLU A CD  1 
ATOM   124  O  OE1 . GLU A 1 24  ? -28.305 -13.880 -0.440  1.00 88.57  ? 287  GLU A OE1 1 
ATOM   125  O  OE2 . GLU A 1 24  ? -27.581 -15.739 0.470   1.00 99.36  ? 287  GLU A OE2 1 
ATOM   126  N  N   . HIS A 1 25  ? -25.601 -13.803 5.694   1.00 99.09  ? 288  HIS A N   1 
ATOM   127  C  CA  . HIS A 1 25  ? -24.734 -14.237 6.823   1.00 103.49 ? 288  HIS A CA  1 
ATOM   128  C  C   . HIS A 1 25  ? -24.115 -13.001 7.506   1.00 110.31 ? 288  HIS A C   1 
ATOM   129  O  O   . HIS A 1 25  ? -22.900 -13.035 7.804   1.00 110.79 ? 288  HIS A O   1 
ATOM   130  C  CB  . HIS A 1 25  ? -23.714 -15.263 6.297   1.00 99.12  ? 288  HIS A CB  1 
ATOM   131  C  CG  . HIS A 1 25  ? -24.325 -16.319 5.433   1.00 92.63  ? 288  HIS A CG  1 
ATOM   132  N  ND1 . HIS A 1 25  ? -25.036 -17.388 5.952   1.00 93.83  ? 288  HIS A ND1 1 
ATOM   133  C  CD2 . HIS A 1 25  ? -24.361 -16.467 4.090   1.00 86.44  ? 288  HIS A CD2 1 
ATOM   134  C  CE1 . HIS A 1 25  ? -25.469 -18.153 4.969   1.00 85.80  ? 288  HIS A CE1 1 
ATOM   135  N  NE2 . HIS A 1 25  ? -25.069 -17.610 3.820   1.00 81.57  ? 288  HIS A NE2 1 
ATOM   136  N  N   . GLU A 1 26  ? -24.910 -11.964 7.786   1.00 112.85 ? 289  GLU A N   1 
ATOM   137  C  CA  . GLU A 1 26  ? -24.364 -10.705 8.375   1.00 112.60 ? 289  GLU A CA  1 
ATOM   138  C  C   . GLU A 1 26  ? -23.944 -10.936 9.836   1.00 113.83 ? 289  GLU A C   1 
ATOM   139  O  O   . GLU A 1 26  ? -23.122 -10.152 10.340  1.00 97.67  ? 289  GLU A O   1 
ATOM   140  C  CB  . GLU A 1 26  ? -25.379 -9.563  8.271   1.00 107.05 ? 289  GLU A CB  1 
ATOM   141  C  CG  . GLU A 1 26  ? -24.792 -8.195  8.569   1.00 103.66 ? 289  GLU A CG  1 
ATOM   142  C  CD  . GLU A 1 26  ? -24.176 -7.478  7.380   1.00 99.70  ? 289  GLU A CD  1 
ATOM   143  O  OE1 . GLU A 1 26  ? -23.285 -6.637  7.596   1.00 105.55 ? 289  GLU A OE1 1 
ATOM   144  O  OE2 . GLU A 1 26  ? -24.600 -7.748  6.242   1.00 93.54  ? 289  GLU A OE2 1 
ATOM   145  N  N   . THR A 1 27  ? -24.481 -11.970 10.490  1.00 114.90 ? 290  THR A N   1 
ATOM   146  C  CA  . THR A 1 27  ? -24.041 -12.292 11.873  1.00 116.91 ? 290  THR A CA  1 
ATOM   147  C  C   . THR A 1 27  ? -22.917 -13.333 11.827  1.00 111.69 ? 290  THR A C   1 
ATOM   148  O  O   . THR A 1 27  ? -22.998 -14.304 12.598  1.00 119.42 ? 290  THR A O   1 
ATOM   149  C  CB  . THR A 1 27  ? -25.208 -12.789 12.735  1.00 117.64 ? 290  THR A CB  1 
ATOM   150  O  OG1 . THR A 1 27  ? -25.546 -14.113 12.322  1.00 132.23 ? 290  THR A OG1 1 
ATOM   151  C  CG2 . THR A 1 27  ? -26.424 -11.893 12.645  1.00 111.57 ? 290  THR A CG2 1 
ATOM   152  N  N   . SER A 1 28  ? -21.924 -13.140 10.955  1.00 100.72 ? 291  SER A N   1 
ATOM   153  C  CA  . SER A 1 28  ? -20.769 -14.071 10.871  1.00 86.34  ? 291  SER A CA  1 
ATOM   154  C  C   . SER A 1 28  ? -19.677 -13.476 9.984   1.00 79.16  ? 291  SER A C   1 
ATOM   155  O  O   . SER A 1 28  ? -18.517 -13.855 10.156  1.00 76.86  ? 291  SER A O   1 
ATOM   156  C  CB  . SER A 1 28  ? -21.203 -15.409 10.357  1.00 85.61  ? 291  SER A CB  1 
ATOM   157  O  OG  . SER A 1 28  ? -21.925 -16.129 11.343  1.00 87.26  ? 291  SER A OG  1 
ATOM   158  N  N   . TRP A 1 29  ? -20.041 -12.590 9.059   1.00 83.18  ? 292  TRP A N   1 
ATOM   159  C  CA  . TRP A 1 29  ? -19.031 -12.082 8.090   1.00 84.82  ? 292  TRP A CA  1 
ATOM   160  C  C   . TRP A 1 29  ? -17.730 -11.744 8.819   1.00 84.80  ? 292  TRP A C   1 
ATOM   161  O  O   . TRP A 1 29  ? -17.766 -10.887 9.713   1.00 93.75  ? 292  TRP A O   1 
ATOM   162  C  CB  . TRP A 1 29  ? -19.564 -10.885 7.299   1.00 76.82  ? 292  TRP A CB  1 
ATOM   163  C  CG  . TRP A 1 29  ? -18.783 -10.595 6.054   1.00 79.57  ? 292  TRP A CG  1 
ATOM   164  C  CD1 . TRP A 1 29  ? -17.973 -9.523  5.819   1.00 81.11  ? 292  TRP A CD1 1 
ATOM   165  C  CD2 . TRP A 1 29  ? -18.732 -11.401 4.865   1.00 76.35  ? 292  TRP A CD2 1 
ATOM   166  N  NE1 . TRP A 1 29  ? -17.426 -9.603  4.567   1.00 75.98  ? 292  TRP A NE1 1 
ATOM   167  C  CE2 . TRP A 1 29  ? -17.872 -10.746 3.959   1.00 80.14  ? 292  TRP A CE2 1 
ATOM   168  C  CE3 . TRP A 1 29  ? -19.326 -12.606 4.477   1.00 73.53  ? 292  TRP A CE3 1 
ATOM   169  C  CZ2 . TRP A 1 29  ? -17.596 -11.259 2.693   1.00 76.90  ? 292  TRP A CZ2 1 
ATOM   170  C  CZ3 . TRP A 1 29  ? -19.054 -13.111 3.226   1.00 72.93  ? 292  TRP A CZ3 1 
ATOM   171  C  CH2 . TRP A 1 29  ? -18.200 -12.445 2.349   1.00 73.97  ? 292  TRP A CH2 1 
ATOM   172  N  N   . HIS A 1 30  ? -16.629 -12.385 8.423   1.00 87.90  ? 293  HIS A N   1 
ATOM   173  C  CA  . HIS A 1 30  ? -15.315 -12.139 9.076   1.00 86.33  ? 293  HIS A CA  1 
ATOM   174  C  C   . HIS A 1 30  ? -14.173 -12.195 8.055   1.00 87.77  ? 293  HIS A C   1 
ATOM   175  O  O   . HIS A 1 30  ? -13.980 -13.257 7.450   1.00 86.31  ? 293  HIS A O   1 
ATOM   176  C  CB  . HIS A 1 30  ? -15.128 -13.102 10.258  1.00 82.75  ? 293  HIS A CB  1 
ATOM   177  C  CG  . HIS A 1 30  ? -14.880 -14.535 9.945   1.00 73.94  ? 293  HIS A CG  1 
ATOM   178  N  ND1 . HIS A 1 30  ? -15.880 -15.480 10.014  1.00 72.59  ? 293  HIS A ND1 1 
ATOM   179  C  CD2 . HIS A 1 30  ? -13.742 -15.200 9.655   1.00 79.23  ? 293  HIS A CD2 1 
ATOM   180  C  CE1 . HIS A 1 30  ? -15.379 -16.664 9.736   1.00 74.97  ? 293  HIS A CE1 1 
ATOM   181  N  NE2 . HIS A 1 30  ? -14.067 -16.519 9.513   1.00 82.31  ? 293  HIS A NE2 1 
ATOM   182  N  N   . TYR A 1 31  ? -13.427 -11.098 7.908   1.00 86.97  ? 294  TYR A N   1 
ATOM   183  C  CA  . TYR A 1 31  ? -12.273 -11.069 6.974   1.00 91.61  ? 294  TYR A CA  1 
ATOM   184  C  C   . TYR A 1 31  ? -11.062 -11.762 7.600   1.00 92.54  ? 294  TYR A C   1 
ATOM   185  O  O   . TYR A 1 31  ? -10.102 -11.072 7.973   1.00 94.77  ? 294  TYR A O   1 
ATOM   186  C  CB  . TYR A 1 31  ? -11.910 -9.631  6.606   1.00 94.86  ? 294  TYR A CB  1 
ATOM   187  C  CG  . TYR A 1 31  ? -10.876 -9.516  5.515   1.00 112.54 ? 294  TYR A CG  1 
ATOM   188  C  CD1 . TYR A 1 31  ? -9.580  -9.113  5.793   1.00 117.51 ? 294  TYR A CD1 1 
ATOM   189  C  CD2 . TYR A 1 31  ? -11.188 -9.826  4.203   1.00 119.85 ? 294  TYR A CD2 1 
ATOM   190  C  CE1 . TYR A 1 31  ? -8.625  -9.011  4.796   1.00 116.48 ? 294  TYR A CE1 1 
ATOM   191  C  CE2 . TYR A 1 31  ? -10.247 -9.727  3.193   1.00 115.89 ? 294  TYR A CE2 1 
ATOM   192  C  CZ  . TYR A 1 31  ? -8.960  -9.320  3.491   1.00 116.18 ? 294  TYR A CZ  1 
ATOM   193  O  OH  . TYR A 1 31  ? -8.028  -9.224  2.500   1.00 126.84 ? 294  TYR A OH  1 
ATOM   194  N  N   . ASP A 1 32  ? -11.093 -13.093 7.673   1.00 94.43  ? 295  ASP A N   1 
ATOM   195  C  CA  . ASP A 1 32  ? -9.944  -13.849 8.233   1.00 93.36  ? 295  ASP A CA  1 
ATOM   196  C  C   . ASP A 1 32  ? -8.650  -13.280 7.648   1.00 100.38 ? 295  ASP A C   1 
ATOM   197  O  O   . ASP A 1 32  ? -8.669  -12.842 6.480   1.00 94.87  ? 295  ASP A O   1 
ATOM   198  C  CB  . ASP A 1 32  ? -10.067 -15.352 7.973   1.00 88.40  ? 295  ASP A CB  1 
ATOM   199  C  CG  . ASP A 1 32  ? -9.063  -16.196 8.734   1.00 82.77  ? 295  ASP A CG  1 
ATOM   200  O  OD1 . ASP A 1 32  ? -8.104  -15.621 9.279   1.00 75.72  ? 295  ASP A OD1 1 
ATOM   201  O  OD2 . ASP A 1 32  ? -9.260  -17.421 8.785   1.00 75.74  ? 295  ASP A OD2 1 
ATOM   202  N  N   . GLN A 1 33  ? -7.582  -13.259 8.446   1.00 97.70  ? 296  GLN A N   1 
ATOM   203  C  CA  . GLN A 1 33  ? -6.270  -12.767 7.955   1.00 97.35  ? 296  GLN A CA  1 
ATOM   204  C  C   . GLN A 1 33  ? -5.327  -13.965 7.885   1.00 95.55  ? 296  GLN A C   1 
ATOM   205  O  O   . GLN A 1 33  ? -4.162  -13.777 7.497   1.00 100.13 ? 296  GLN A O   1 
ATOM   206  C  CB  . GLN A 1 33  ? -5.740  -11.638 8.840   1.00 89.96  ? 296  GLN A CB  1 
ATOM   207  C  CG  . GLN A 1 33  ? -6.554  -10.356 8.740   1.00 92.51  ? 296  GLN A CG  1 
ATOM   208  C  CD  . GLN A 1 33  ? -5.754  -9.214  8.163   1.00 97.68  ? 296  GLN A CD  1 
ATOM   209  O  OE1 . GLN A 1 33  ? -4.529  -9.264  8.088   1.00 102.05 ? 296  GLN A OE1 1 
ATOM   210  N  NE2 . GLN A 1 33  ? -6.446  -8.165  7.750   1.00 98.46  ? 296  GLN A NE2 1 
ATOM   211  N  N   . ASP A 1 34  ? -5.825  -15.145 8.249   1.00 95.67  ? 297  ASP A N   1 
ATOM   212  C  CA  . ASP A 1 34  ? -5.007  -16.378 8.144   1.00 102.24 ? 297  ASP A CA  1 
ATOM   213  C  C   . ASP A 1 34  ? -5.505  -17.192 6.949   1.00 110.54 ? 297  ASP A C   1 
ATOM   214  O  O   . ASP A 1 34  ? -5.405  -18.429 7.013   1.00 118.91 ? 297  ASP A O   1 
ATOM   215  C  CB  . ASP A 1 34  ? -5.074  -17.199 9.431   1.00 102.46 ? 297  ASP A CB  1 
ATOM   216  C  CG  . ASP A 1 34  ? -4.404  -16.538 10.623  1.00 102.08 ? 297  ASP A CG  1 
ATOM   217  O  OD1 . ASP A 1 34  ? -3.671  -15.552 10.414  1.00 104.05 ? 297  ASP A OD1 1 
ATOM   218  O  OD2 . ASP A 1 34  ? -4.629  -17.012 11.751  1.00 98.21  ? 297  ASP A OD2 1 
ATOM   219  N  N   . HIS A 1 35  ? -6.032  -16.527 5.912   1.00 107.00 ? 298  HIS A N   1 
ATOM   220  C  CA  . HIS A 1 35  ? -6.632  -17.252 4.754   1.00 91.44  ? 298  HIS A CA  1 
ATOM   221  C  C   . HIS A 1 35  ? -5.543  -17.978 3.953   1.00 88.56  ? 298  HIS A C   1 
ATOM   222  O  O   . HIS A 1 35  ? -4.448  -17.415 3.806   1.00 79.66  ? 298  HIS A O   1 
ATOM   223  C  CB  . HIS A 1 35  ? -7.506  -16.305 3.916   1.00 83.19  ? 298  HIS A CB  1 
ATOM   224  C  CG  . HIS A 1 35  ? -6.763  -15.321 3.080   1.00 76.19  ? 298  HIS A CG  1 
ATOM   225  N  ND1 . HIS A 1 35  ? -6.818  -13.966 3.322   1.00 84.00  ? 298  HIS A ND1 1 
ATOM   226  C  CD2 . HIS A 1 35  ? -5.980  -15.483 1.994   1.00 70.89  ? 298  HIS A CD2 1 
ATOM   227  C  CE1 . HIS A 1 35  ? -6.085  -13.333 2.432   1.00 80.43  ? 298  HIS A CE1 1 
ATOM   228  N  NE2 . HIS A 1 35  ? -5.557  -14.242 1.608   1.00 79.43  ? 298  HIS A NE2 1 
ATOM   229  N  N   . PRO A 1 36  ? -5.804  -19.203 3.442   1.00 80.64  ? 299  PRO A N   1 
ATOM   230  C  CA  . PRO A 1 36  ? -4.793  -19.986 2.726   1.00 75.34  ? 299  PRO A CA  1 
ATOM   231  C  C   . PRO A 1 36  ? -4.712  -19.749 1.215   1.00 86.21  ? 299  PRO A C   1 
ATOM   232  O  O   . PRO A 1 36  ? -4.146  -20.590 0.546   1.00 91.23  ? 299  PRO A O   1 
ATOM   233  C  CB  . PRO A 1 36  ? -5.375  -21.384 2.884   1.00 75.91  ? 299  PRO A CB  1 
ATOM   234  C  CG  . PRO A 1 36  ? -6.860  -21.170 2.769   1.00 75.92  ? 299  PRO A CG  1 
ATOM   235  C  CD  . PRO A 1 36  ? -7.093  -19.890 3.537   1.00 79.84  ? 299  PRO A CD  1 
ATOM   236  N  N   . TYR A 1 37  ? -5.249  -18.635 0.721   1.00 84.95  ? 300  TYR A N   1 
ATOM   237  C  CA  . TYR A 1 37  ? -5.326  -18.359 -0.738  1.00 77.34  ? 300  TYR A CA  1 
ATOM   238  C  C   . TYR A 1 37  ? -4.186  -17.414 -1.116  1.00 81.68  ? 300  TYR A C   1 
ATOM   239  O  O   . TYR A 1 37  ? -4.019  -16.380 -0.427  1.00 84.43  ? 300  TYR A O   1 
ATOM   240  C  CB  . TYR A 1 37  ? -6.714  -17.806 -1.100  1.00 73.81  ? 300  TYR A CB  1 
ATOM   241  C  CG  . TYR A 1 37  ? -7.838  -18.677 -0.600  1.00 62.06  ? 300  TYR A CG  1 
ATOM   242  C  CD1 . TYR A 1 37  ? -8.132  -19.881 -1.208  1.00 61.71  ? 300  TYR A CD1 1 
ATOM   243  C  CD2 . TYR A 1 37  ? -8.546  -18.352 0.542   1.00 62.99  ? 300  TYR A CD2 1 
ATOM   244  C  CE1 . TYR A 1 37  ? -9.117  -20.724 -0.721  1.00 59.99  ? 300  TYR A CE1 1 
ATOM   245  C  CE2 . TYR A 1 37  ? -9.532  -19.184 1.044   1.00 56.95  ? 300  TYR A CE2 1 
ATOM   246  C  CZ  . TYR A 1 37  ? -9.822  -20.371 0.408   1.00 53.98  ? 300  TYR A CZ  1 
ATOM   247  O  OH  . TYR A 1 37  ? -10.785 -21.198 0.889   1.00 62.12  ? 300  TYR A OH  1 
ATOM   248  N  N   . LYS A 1 38  ? -3.430  -17.765 -2.164  1.00 82.43  ? 301  LYS A N   1 
ATOM   249  C  CA  . LYS A 1 38  ? -2.476  -16.840 -2.840  1.00 86.38  ? 301  LYS A CA  1 
ATOM   250  C  C   . LYS A 1 38  ? -3.010  -16.409 -4.214  1.00 86.35  ? 301  LYS A C   1 
ATOM   251  O  O   . LYS A 1 38  ? -3.012  -15.191 -4.472  1.00 88.56  ? 301  LYS A O   1 
ATOM   252  C  CB  . LYS A 1 38  ? -1.084  -17.460 -2.996  1.00 86.88  ? 301  LYS A CB  1 
ATOM   253  C  CG  . LYS A 1 38  ? 0.022   -16.460 -3.333  1.00 91.38  ? 301  LYS A CG  1 
ATOM   254  C  CD  . LYS A 1 38  ? 0.271   -15.409 -2.257  1.00 92.95  ? 301  LYS A CD  1 
ATOM   255  C  CE  . LYS A 1 38  ? 1.114   -14.239 -2.729  1.00 102.38 ? 301  LYS A CE  1 
ATOM   256  N  NZ  . LYS A 1 38  ? 2.569   -14.514 -2.629  1.00 102.91 ? 301  LYS A NZ  1 
ATOM   257  N  N   . THR A 1 39  ? -3.433  -17.357 -5.064  1.00 84.13  ? 302  THR A N   1 
ATOM   258  C  CA  . THR A 1 39  ? -3.823  -17.115 -6.488  1.00 75.72  ? 302  THR A CA  1 
ATOM   259  C  C   . THR A 1 39  ? -5.307  -16.726 -6.601  1.00 69.51  ? 302  THR A C   1 
ATOM   260  O  O   . THR A 1 39  ? -5.659  -15.974 -7.520  1.00 68.45  ? 302  THR A O   1 
ATOM   261  C  CB  . THR A 1 39  ? -3.484  -18.330 -7.350  1.00 70.59  ? 302  THR A CB  1 
ATOM   262  O  OG1 . THR A 1 39  ? -4.399  -19.347 -6.946  1.00 68.86  ? 302  THR A OG1 1 
ATOM   263  C  CG2 . THR A 1 39  ? -2.047  -18.777 -7.187  1.00 70.42  ? 302  THR A CG2 1 
ATOM   264  N  N   . TRP A 1 40  ? -6.139  -17.260 -5.699  0.50 69.57  ? 303  TRP A N   1 
ATOM   265  C  CA  . TRP A 1 40  ? -7.565  -16.884 -5.510  0.50 68.92  ? 303  TRP A CA  1 
ATOM   266  C  C   . TRP A 1 40  ? -7.644  -15.600 -4.683  0.50 70.99  ? 303  TRP A C   1 
ATOM   267  O  O   . TRP A 1 40  ? -7.019  -15.567 -3.608  0.50 74.07  ? 303  TRP A O   1 
ATOM   268  C  CB  . TRP A 1 40  ? -8.328  -18.007 -4.803  0.50 68.79  ? 303  TRP A CB  1 
ATOM   269  C  CG  . TRP A 1 40  ? -8.562  -19.226 -5.636  0.50 67.62  ? 303  TRP A CG  1 
ATOM   270  C  CD1 . TRP A 1 40  ? -7.729  -20.294 -5.789  0.50 69.30  ? 303  TRP A CD1 1 
ATOM   271  C  CD2 . TRP A 1 40  ? -9.734  -19.517 -6.415  0.50 67.12  ? 303  TRP A CD2 1 
ATOM   272  N  NE1 . TRP A 1 40  ? -8.296  -21.224 -6.617  0.50 69.83  ? 303  TRP A NE1 1 
ATOM   273  C  CE2 . TRP A 1 40  ? -9.528  -20.777 -7.014  0.50 68.15  ? 303  TRP A CE2 1 
ATOM   274  C  CE3 . TRP A 1 40  ? -10.929 -18.836 -6.663  0.50 65.02  ? 303  TRP A CE3 1 
ATOM   275  C  CZ2 . TRP A 1 40  ? -10.476 -21.364 -7.850  0.50 67.38  ? 303  TRP A CZ2 1 
ATOM   276  C  CZ3 . TRP A 1 40  ? -11.865 -19.418 -7.487  0.50 67.16  ? 303  TRP A CZ3 1 
ATOM   277  C  CH2 . TRP A 1 40  ? -11.640 -20.665 -8.069  0.50 66.22  ? 303  TRP A CH2 1 
ATOM   278  N  N   . ALA A 1 41  ? -8.501  -14.662 -5.095  0.50 69.41  ? 304  ALA A N   1 
ATOM   279  C  CA  . ALA A 1 41  ? -8.742  -13.453 -4.277  0.50 68.86  ? 304  ALA A CA  1 
ATOM   280  C  C   . ALA A 1 41  ? -9.751  -13.806 -3.182  0.50 68.76  ? 304  ALA A C   1 
ATOM   281  O  O   . ALA A 1 41  ? -10.839 -14.292 -3.525  0.50 66.16  ? 304  ALA A O   1 
ATOM   282  C  CB  . ALA A 1 41  ? -9.251  -12.330 -5.141  0.50 66.36  ? 304  ALA A CB  1 
ATOM   283  N  N   . TYR A 1 42  ? -9.384  -13.589 -1.916  0.50 70.64  ? 305  TYR A N   1 
ATOM   284  C  CA  . TYR A 1 42  ? -10.281 -13.896 -0.772  0.50 69.95  ? 305  TYR A CA  1 
ATOM   285  C  C   . TYR A 1 42  ? -11.133 -12.664 -0.472  0.50 69.15  ? 305  TYR A C   1 
ATOM   286  O  O   . TYR A 1 42  ? -10.623 -11.536 -0.599  0.50 71.83  ? 305  TYR A O   1 
ATOM   287  C  CB  . TYR A 1 42  ? -9.455  -14.319 0.444   0.50 70.25  ? 305  TYR A CB  1 
ATOM   288  C  CG  . TYR A 1 42  ? -10.202 -14.390 1.750   0.50 69.56  ? 305  TYR A CG  1 
ATOM   289  C  CD1 . TYR A 1 42  ? -10.961 -15.499 2.081   0.50 67.97  ? 305  TYR A CD1 1 
ATOM   290  C  CD2 . TYR A 1 42  ? -10.128 -13.357 2.668   0.50 69.13  ? 305  TYR A CD2 1 
ATOM   291  C  CE1 . TYR A 1 42  ? -11.640 -15.574 3.285   0.50 68.48  ? 305  TYR A CE1 1 
ATOM   292  C  CE2 . TYR A 1 42  ? -10.801 -13.414 3.876   0.50 67.75  ? 305  TYR A CE2 1 
ATOM   293  C  CZ  . TYR A 1 42  ? -11.560 -14.527 4.186   0.50 68.66  ? 305  TYR A CZ  1 
ATOM   294  O  OH  . TYR A 1 42  ? -12.225 -14.589 5.374   0.50 69.67  ? 305  TYR A OH  1 
ATOM   295  N  N   . HIS A 1 43  ? -12.392 -12.875 -0.098  0.50 68.72  ? 306  HIS A N   1 
ATOM   296  C  CA  . HIS A 1 43  ? -13.300 -11.722 0.130   0.50 67.11  ? 306  HIS A CA  1 
ATOM   297  C  C   . HIS A 1 43  ? -13.828 -11.747 1.568   0.50 68.29  ? 306  HIS A C   1 
ATOM   298  O  O   . HIS A 1 43  ? -13.952 -10.664 2.163   0.50 72.01  ? 306  HIS A O   1 
ATOM   299  C  CB  . HIS A 1 43  ? -14.413 -11.711 -0.926  0.50 63.46  ? 306  HIS A CB  1 
ATOM   300  C  CG  . HIS A 1 43  ? -13.921 -11.479 -2.314  0.50 59.46  ? 306  HIS A CG  1 
ATOM   301  N  ND1 . HIS A 1 43  ? -13.687 -10.213 -2.811  0.50 56.50  ? 306  HIS A ND1 1 
ATOM   302  C  CD2 . HIS A 1 43  ? -13.622 -12.338 -3.311  0.50 58.25  ? 306  HIS A CD2 1 
ATOM   303  C  CE1 . HIS A 1 43  ? -13.264 -10.301 -4.054  0.50 55.63  ? 306  HIS A CE1 1 
ATOM   304  N  NE2 . HIS A 1 43  ? -13.216 -11.594 -4.384  0.50 56.31  ? 306  HIS A NE2 1 
ATOM   305  N  N   . GLY A 1 44  ? -14.134 -12.932 2.094   0.50 68.88  ? 307  GLY A N   1 
ATOM   306  C  CA  . GLY A 1 44  ? -14.694 -13.022 3.454   0.50 69.24  ? 307  GLY A CA  1 
ATOM   307  C  C   . GLY A 1 44  ? -15.050 -14.440 3.843   0.50 71.32  ? 307  GLY A C   1 
ATOM   308  O  O   . GLY A 1 44  ? -14.882 -15.342 3.005   0.50 71.19  ? 307  GLY A O   1 
ATOM   309  N  N   . SER A 1 45  ? -15.539 -14.625 5.072   0.50 72.56  ? 308  SER A N   1 
ATOM   310  C  CA  . SER A 1 45  ? -15.905 -15.974 5.568   0.50 73.30  ? 308  SER A CA  1 
ATOM   311  C  C   . SER A 1 45  ? -17.225 -15.901 6.336   0.50 74.83  ? 308  SER A C   1 
ATOM   312  O  O   . SER A 1 45  ? -17.646 -14.780 6.657   0.50 77.97  ? 308  SER A O   1 
ATOM   313  C  CB  . SER A 1 45  ? -14.810 -16.541 6.426   0.50 73.74  ? 308  SER A CB  1 
ATOM   314  O  OG  . SER A 1 45  ? -13.593 -16.630 5.702   0.50 72.37  ? 308  SER A OG  1 
ATOM   315  N  N   . TYR A 1 46  ? -17.845 -17.051 6.607   1.00 76.25  ? 309  TYR A N   1 
ATOM   316  C  CA  . TYR A 1 46  ? -19.123 -17.104 7.384   1.00 81.87  ? 309  TYR A CA  1 
ATOM   317  C  C   . TYR A 1 46  ? -19.329 -18.543 7.906   1.00 88.77  ? 309  TYR A C   1 
ATOM   318  O  O   . TYR A 1 46  ? -18.736 -19.489 7.359   1.00 95.15  ? 309  TYR A O   1 
ATOM   319  C  CB  . TYR A 1 46  ? -20.300 -16.534 6.570   1.00 81.42  ? 309  TYR A CB  1 
ATOM   320  C  CG  . TYR A 1 46  ? -20.851 -17.407 5.466   1.00 81.42  ? 309  TYR A CG  1 
ATOM   321  C  CD1 . TYR A 1 46  ? -21.709 -18.452 5.762   1.00 77.26  ? 309  TYR A CD1 1 
ATOM   322  C  CD2 . TYR A 1 46  ? -20.569 -17.167 4.124   1.00 82.12  ? 309  TYR A CD2 1 
ATOM   323  C  CE1 . TYR A 1 46  ? -22.236 -19.263 4.769   1.00 84.33  ? 309  TYR A CE1 1 
ATOM   324  C  CE2 . TYR A 1 46  ? -21.096 -17.968 3.116   1.00 77.73  ? 309  TYR A CE2 1 
ATOM   325  C  CZ  . TYR A 1 46  ? -21.932 -19.025 3.441   1.00 79.52  ? 309  TYR A CZ  1 
ATOM   326  O  OH  . TYR A 1 46  ? -22.478 -19.858 2.500   1.00 72.26  ? 309  TYR A OH  1 
ATOM   327  N  N   . GLU A 1 47  ? -20.162 -18.693 8.943   0.50 89.51  ? 310  GLU A N   1 
ATOM   328  C  CA  . GLU A 1 47  ? -20.352 -19.954 9.714   0.50 93.00  ? 310  GLU A CA  1 
ATOM   329  C  C   . GLU A 1 47  ? -21.193 -20.952 8.909   0.50 91.43  ? 310  GLU A C   1 
ATOM   330  O  O   . GLU A 1 47  ? -22.227 -20.542 8.345   0.50 93.72  ? 310  GLU A O   1 
ATOM   331  C  CB  . GLU A 1 47  ? -21.018 -19.660 11.062  0.50 97.08  ? 310  GLU A CB  1 
ATOM   332  C  CG  . GLU A 1 47  ? -21.470 -20.908 11.805  0.50 98.57  ? 310  GLU A CG  1 
ATOM   333  C  CD  . GLU A 1 47  ? -21.795 -20.685 13.273  0.50 100.04 ? 310  GLU A CD  1 
ATOM   334  O  OE1 . GLU A 1 47  ? -22.958 -20.923 13.665  0.50 101.25 ? 310  GLU A OE1 1 
ATOM   335  O  OE2 . GLU A 1 47  ? -20.883 -20.280 14.023  0.50 99.79  ? 310  GLU A OE2 1 
ATOM   336  N  N   . THR A 1 48  ? -20.771 -22.220 8.893   0.50 89.66  ? 311  THR A N   1 
ATOM   337  C  CA  . THR A 1 48  ? -21.434 -23.339 8.171   0.50 88.39  ? 311  THR A CA  1 
ATOM   338  C  C   . THR A 1 48  ? -21.028 -24.667 8.820   0.50 87.06  ? 311  THR A C   1 
ATOM   339  O  O   . THR A 1 48  ? -20.109 -24.624 9.663   0.50 86.90  ? 311  THR A O   1 
ATOM   340  C  CB  . THR A 1 48  ? -21.084 -23.311 6.678   0.50 88.64  ? 311  THR A CB  1 
ATOM   341  O  OG1 . THR A 1 48  ? -21.692 -24.449 6.065   0.50 88.58  ? 311  THR A OG1 1 
ATOM   342  C  CG2 . THR A 1 48  ? -19.593 -23.320 6.422   0.50 89.03  ? 311  THR A CG2 1 
ATOM   343  N  N   . ALA A 1 54  ? -19.824 -38.248 1.356   0.50 89.50  ? 317  ALA A N   1 
ATOM   344  C  CA  . ALA A 1 54  ? -20.288 -38.804 0.062   0.50 88.67  ? 317  ALA A CA  1 
ATOM   345  C  C   . ALA A 1 54  ? -19.293 -39.864 -0.430  0.50 87.33  ? 317  ALA A C   1 
ATOM   346  O  O   . ALA A 1 54  ? -18.847 -39.766 -1.592  0.50 87.47  ? 317  ALA A O   1 
ATOM   347  C  CB  . ALA A 1 54  ? -20.456 -37.691 -0.945  0.50 86.39  ? 317  ALA A CB  1 
ATOM   348  N  N   . SER A 1 55  ? -18.964 -40.837 0.429   0.50 83.15  ? 318  SER A N   1 
ATOM   349  C  CA  . SER A 1 55  ? -18.028 -41.956 0.138   0.50 76.15  ? 318  SER A CA  1 
ATOM   350  C  C   . SER A 1 55  ? -18.696 -42.962 -0.811  0.50 69.80  ? 318  SER A C   1 
ATOM   351  O  O   . SER A 1 55  ? -19.938 -42.930 -0.953  0.50 65.65  ? 318  SER A O   1 
ATOM   352  C  CB  . SER A 1 55  ? -17.555 -42.625 1.408   0.50 76.01  ? 318  SER A CB  1 
ATOM   353  O  OG  . SER A 1 55  ? -18.515 -43.557 1.886   0.50 76.01  ? 318  SER A OG  1 
ATOM   354  N  N   . SER A 1 56  ? -17.884 -43.812 -1.444  0.50 63.41  ? 319  SER A N   1 
ATOM   355  C  CA  . SER A 1 56  ? -18.316 -44.886 -2.372  0.50 60.85  ? 319  SER A CA  1 
ATOM   356  C  C   . SER A 1 56  ? -18.837 -46.076 -1.557  0.50 57.35  ? 319  SER A C   1 
ATOM   357  O  O   . SER A 1 56  ? -18.183 -46.433 -0.556  0.50 54.36  ? 319  SER A O   1 
ATOM   358  C  CB  . SER A 1 56  ? -17.184 -45.288 -3.285  0.50 64.54  ? 319  SER A CB  1 
ATOM   359  O  OG  . SER A 1 56  ? -16.163 -45.974 -2.570  0.50 63.09  ? 319  SER A OG  1 
ATOM   360  N  N   . MET A 1 57  ? -19.980 -46.643 -1.958  1.00 51.43  ? 320  MET A N   1 
ATOM   361  C  CA  . MET A 1 57  ? -20.600 -47.827 -1.295  1.00 41.24  ? 320  MET A CA  1 
ATOM   362  C  C   . MET A 1 57  ? -20.405 -49.080 -2.176  1.00 28.54  ? 320  MET A C   1 
ATOM   363  O  O   . MET A 1 57  ? -20.308 -48.913 -3.395  1.00 31.32  ? 320  MET A O   1 
ATOM   364  C  CB  . MET A 1 57  ? -22.086 -47.523 -1.163  1.00 41.45  ? 320  MET A CB  1 
ATOM   365  C  CG  . MET A 1 57  ? -22.354 -46.087 -0.632  1.00 45.43  ? 320  MET A CG  1 
ATOM   366  S  SD  . MET A 1 57  ? -21.697 -45.922 1.047   1.00 47.14  ? 320  MET A SD  1 
ATOM   367  C  CE  . MET A 1 57  ? -22.853 -46.981 1.919   1.00 43.21  ? 320  MET A CE  1 
ATOM   368  N  N   . VAL A 1 58  ? -20.396 -50.277 -1.618  1.00 25.65  ? 321  VAL A N   1 
ATOM   369  C  CA  . VAL A 1 58  ? -20.192 -51.512 -2.433  1.00 25.42  ? 321  VAL A CA  1 
ATOM   370  C  C   . VAL A 1 58  ? -21.527 -52.010 -2.976  1.00 27.51  ? 321  VAL A C   1 
ATOM   371  O  O   . VAL A 1 58  ? -22.478 -52.028 -2.171  1.00 28.25  ? 321  VAL A O   1 
ATOM   372  C  CB  . VAL A 1 58  ? -19.445 -52.609 -1.672  1.00 27.50  ? 321  VAL A CB  1 
ATOM   373  C  CG1 . VAL A 1 58  ? -19.346 -53.885 -2.513  1.00 25.56  ? 321  VAL A CG1 1 
ATOM   374  C  CG2 . VAL A 1 58  ? -18.078 -52.092 -1.300  1.00 32.85  ? 321  VAL A CG2 1 
ATOM   375  N  N   . ASN A 1 59  ? -21.566 -52.375 -4.280  1.00 21.62  ? 322  ASN A N   1 
ATOM   376  C  CA  . ASN A 1 59  ? -22.667 -53.106 -4.930  1.00 21.15  ? 322  ASN A CA  1 
ATOM   377  C  C   . ASN A 1 59  ? -22.583 -54.595 -4.584  1.00 23.72  ? 322  ASN A C   1 
ATOM   378  O  O   . ASN A 1 59  ? -21.724 -55.308 -5.131  1.00 22.75  ? 322  ASN A O   1 
ATOM   379  C  CB  . ASN A 1 59  ? -22.691 -52.887 -6.438  1.00 21.79  ? 322  ASN A CB  1 
ATOM   380  C  CG  . ASN A 1 59  ? -23.937 -53.480 -7.073  1.00 21.12  ? 322  ASN A CG  1 
ATOM   381  O  OD1 . ASN A 1 59  ? -24.345 -54.597 -6.748  1.00 22.41  ? 322  ASN A OD1 1 
ATOM   382  N  ND2 . ASN A 1 59  ? -24.507 -52.756 -8.036  1.00 23.74  ? 322  ASN A ND2 1 
ATOM   383  N  N   . GLY A 1 60  ? -23.434 -55.040 -3.674  1.00 23.15  ? 323  GLY A N   1 
ATOM   384  C  CA  . GLY A 1 60  ? -23.480 -56.425 -3.182  1.00 22.46  ? 323  GLY A CA  1 
ATOM   385  C  C   . GLY A 1 60  ? -23.794 -57.479 -4.229  1.00 25.80  ? 323  GLY A C   1 
ATOM   386  O  O   . GLY A 1 60  ? -23.275 -58.637 -4.145  1.00 25.25  ? 323  GLY A O   1 
ATOM   387  N  N   . VAL A 1 61  ? -24.661 -57.157 -5.186  1.00 23.14  ? 324  VAL A N   1 
ATOM   388  C  CA  . VAL A 1 61  ? -24.979 -58.099 -6.280  1.00 23.44  ? 324  VAL A CA  1 
ATOM   389  C  C   . VAL A 1 61  ? -23.720 -58.386 -7.100  1.00 22.53  ? 324  VAL A C   1 
ATOM   390  O  O   . VAL A 1 61  ? -23.404 -59.578 -7.303  1.00 21.61  ? 324  VAL A O   1 
ATOM   391  C  CB  . VAL A 1 61  ? -26.161 -57.569 -7.111  1.00 23.39  ? 324  VAL A CB  1 
ATOM   392  C  CG1 . VAL A 1 61  ? -26.353 -58.339 -8.367  1.00 23.84  ? 324  VAL A CG1 1 
ATOM   393  C  CG2 . VAL A 1 61  ? -27.428 -57.522 -6.253  1.00 25.49  ? 324  VAL A CG2 1 
ATOM   394  N  N   . VAL A 1 62  ? -23.000 -57.349 -7.534  1.00 20.68  ? 325  VAL A N   1 
ATOM   395  C  CA  . VAL A 1 62  ? -21.772 -57.542 -8.363  1.00 20.65  ? 325  VAL A CA  1 
ATOM   396  C  C   . VAL A 1 62  ? -20.701 -58.249 -7.499  1.00 19.57  ? 325  VAL A C   1 
ATOM   397  O  O   . VAL A 1 62  ? -20.054 -59.229 -7.969  1.00 20.28  ? 325  VAL A O   1 
ATOM   398  C  CB  . VAL A 1 62  ? -21.297 -56.211 -8.978  1.00 20.90  ? 325  VAL A CB  1 
ATOM   399  C  CG1 . VAL A 1 62  ? -19.991 -56.397 -9.729  1.00 20.02  ? 325  VAL A CG1 1 
ATOM   400  C  CG2 . VAL A 1 62  ? -22.353 -55.616 -9.878  1.00 22.74  ? 325  VAL A CG2 1 
ATOM   401  N  N   . ARG A 1 63  ? -20.524 -57.844 -6.247  1.00 19.75  ? 326  ARG A N   1 
ATOM   402  C  CA  . ARG A 1 63  ? -19.428 -58.416 -5.436  1.00 20.09  ? 326  ARG A CA  1 
ATOM   403  C  C   . ARG A 1 63  ? -19.705 -59.892 -5.180  1.00 20.07  ? 326  ARG A C   1 
ATOM   404  O  O   . ARG A 1 63  ? -18.781 -60.706 -5.326  1.00 20.04  ? 326  ARG A O   1 
ATOM   405  C  CB  . ARG A 1 63  ? -19.202 -57.676 -4.131  1.00 18.62  ? 326  ARG A CB  1 
ATOM   406  C  CG  . ARG A 1 63  ? -18.118 -58.350 -3.296  1.00 19.57  ? 326  ARG A CG  1 
ATOM   407  C  CD  . ARG A 1 63  ? -17.439 -57.412 -2.316  1.00 18.61  ? 326  ARG A CD  1 
ATOM   408  N  NE  . ARG A 1 63  ? -18.337 -56.918 -1.294  1.00 20.65  ? 326  ARG A NE  1 
ATOM   409  C  CZ  . ARG A 1 63  ? -17.996 -56.115 -0.286  1.00 21.29  ? 326  ARG A CZ  1 
ATOM   410  N  NH1 . ARG A 1 63  ? -16.728 -55.760 -0.111  1.00 21.47  ? 326  ARG A NH1 1 
ATOM   411  N  NH2 . ARG A 1 63  ? -18.903 -55.668 0.566   1.00 21.87  ? 326  ARG A NH2 1 
ATOM   412  N  N   . LEU A 1 64  ? -20.938 -60.289 -4.869  1.00 20.67  ? 327  LEU A N   1 
ATOM   413  C  CA  . LEU A 1 64  ? -21.229 -61.732 -4.630  1.00 20.91  ? 327  LEU A CA  1 
ATOM   414  C  C   . LEU A 1 64  ? -20.964 -62.563 -5.876  1.00 19.62  ? 327  LEU A C   1 
ATOM   415  O  O   . LEU A 1 64  ? -20.701 -63.763 -5.732  1.00 23.21  ? 327  LEU A O   1 
ATOM   416  C  CB  . LEU A 1 64  ? -22.671 -61.960 -4.128  1.00 21.02  ? 327  LEU A CB  1 
ATOM   417  C  CG  . LEU A 1 64  ? -22.915 -61.596 -2.670  1.00 21.76  ? 327  LEU A CG  1 
ATOM   418  C  CD1 . LEU A 1 64  ? -24.409 -61.735 -2.294  1.00 24.52  ? 327  LEU A CD1 1 
ATOM   419  C  CD2 . LEU A 1 64  ? -22.076 -62.424 -1.732  1.00 22.53  ? 327  LEU A CD2 1 
ATOM   420  N  N   . LEU A 1 65  ? -21.046 -61.995 -7.069  1.00 21.43  ? 328  LEU A N   1 
ATOM   421  C  CA  . LEU A 1 65  ? -20.869 -62.770 -8.329  1.00 20.74  ? 328  LEU A CA  1 
ATOM   422  C  C   . LEU A 1 65  ? -19.447 -62.634 -8.907  1.00 19.36  ? 328  LEU A C   1 
ATOM   423  O  O   . LEU A 1 65  ? -19.207 -63.151 -9.984  1.00 20.22  ? 328  LEU A O   1 
ATOM   424  C  CB  . LEU A 1 65  ? -21.955 -62.310 -9.288  1.00 22.01  ? 328  LEU A CB  1 
ATOM   425  C  CG  . LEU A 1 65  ? -23.361 -62.744 -8.819  1.00 22.90  ? 328  LEU A CG  1 
ATOM   426  C  CD1 . LEU A 1 65  ? -24.443 -62.155 -9.661  1.00 22.81  ? 328  LEU A CD1 1 
ATOM   427  C  CD2 . LEU A 1 65  ? -23.476 -64.242 -8.824  1.00 25.05  ? 328  LEU A CD2 1 
ATOM   428  N  N   . THR A 1 66  ? -18.551 -61.998 -8.176  1.00 19.34  ? 329  THR A N   1 
ATOM   429  C  CA  . THR A 1 66  ? -17.133 -61.800 -8.562  1.00 20.59  ? 329  THR A CA  1 
ATOM   430  C  C   . THR A 1 66  ? -16.223 -62.178 -7.369  1.00 19.74  ? 329  THR A C   1 
ATOM   431  O  O   . THR A 1 66  ? -15.167 -61.525 -7.091  1.00 18.88  ? 329  THR A O   1 
ATOM   432  C  CB  . THR A 1 66  ? -16.925 -60.367 -9.116  1.00 20.20  ? 329  THR A CB  1 
ATOM   433  O  OG1 . THR A 1 66  ? -17.322 -59.352 -8.179  1.00 18.28  ? 329  THR A OG1 1 
ATOM   434  C  CG2 . THR A 1 66  ? -17.640 -60.148 -10.423 1.00 21.40  ? 329  THR A CG2 1 
ATOM   435  N  N   . LYS A 1 67  ? -16.482 -63.292 -6.723  1.00 19.25  ? 330  LYS A N   1 
ATOM   436  C  CA  . LYS A 1 67  ? -15.767 -63.706 -5.492  1.00 20.20  ? 330  LYS A CA  1 
ATOM   437  C  C   . LYS A 1 67  ? -14.236 -63.786 -5.673  1.00 20.10  ? 330  LYS A C   1 
ATOM   438  O  O   . LYS A 1 67  ? -13.532 -63.373 -4.769  1.00 18.96  ? 330  LYS A O   1 
ATOM   439  C  CB  . LYS A 1 67  ? -16.296 -65.048 -4.986  1.00 24.47  ? 330  LYS A CB  1 
ATOM   440  C  CG  . LYS A 1 67  ? -15.787 -65.464 -3.611  1.00 23.92  ? 330  LYS A CG  1 
ATOM   441  C  CD  . LYS A 1 67  ? -16.343 -66.820 -3.175  1.00 25.86  ? 330  LYS A CD  1 
ATOM   442  C  CE  . LYS A 1 67  ? -16.224 -66.949 -1.662  1.00 32.66  ? 330  LYS A CE  1 
ATOM   443  N  NZ  . LYS A 1 67  ? -16.286 -68.360 -1.257  1.00 34.61  ? 330  LYS A NZ  1 
ATOM   444  N  N   . PRO A 1 68  ? -13.653 -64.274 -6.773  1.00 18.98  ? 331  PRO A N   1 
ATOM   445  C  CA  . PRO A 1 68  ? -12.184 -64.394 -6.865  1.00 19.12  ? 331  PRO A CA  1 
ATOM   446  C  C   . PRO A 1 68  ? -11.484 -63.036 -6.669  1.00 22.90  ? 331  PRO A C   1 
ATOM   447  O  O   . PRO A 1 68  ? -10.309 -63.010 -6.250  1.00 21.59  ? 331  PRO A O   1 
ATOM   448  C  CB  . PRO A 1 68  ? -11.981 -64.815 -8.332  1.00 21.76  ? 331  PRO A CB  1 
ATOM   449  C  CG  . PRO A 1 68  ? -13.199 -65.687 -8.601  1.00 22.53  ? 331  PRO A CG  1 
ATOM   450  C  CD  . PRO A 1 68  ? -14.327 -64.917 -7.925  1.00 22.06  ? 331  PRO A CD  1 
ATOM   451  N  N   . TRP A 1 69  ? -12.193 -61.924 -6.983  1.00 20.00  ? 332  TRP A N   1 
ATOM   452  C  CA  . TRP A 1 69  ? -11.616 -60.552 -6.924  1.00 19.63  ? 332  TRP A CA  1 
ATOM   453  C  C   . TRP A 1 69  ? -11.652 -60.034 -5.488  1.00 20.37  ? 332  TRP A C   1 
ATOM   454  O  O   . TRP A 1 69  ? -11.055 -58.948 -5.242  1.00 22.95  ? 332  TRP A O   1 
ATOM   455  C  CB  . TRP A 1 69  ? -12.247 -59.645 -7.991  1.00 18.17  ? 332  TRP A CB  1 
ATOM   456  C  CG  . TRP A 1 69  ? -11.903 -60.074 -9.387  1.00 19.24  ? 332  TRP A CG  1 
ATOM   457  C  CD1 . TRP A 1 69  ? -10.803 -59.652 -10.077 1.00 19.04  ? 332  TRP A CD1 1 
ATOM   458  C  CD2 . TRP A 1 69  ? -12.512 -61.106 -10.201 1.00 20.73  ? 332  TRP A CD2 1 
ATOM   459  N  NE1 . TRP A 1 69  ? -10.699 -60.326 -11.265 1.00 20.63  ? 332  TRP A NE1 1 
ATOM   460  C  CE2 . TRP A 1 69  ? -11.720 -61.230 -11.362 1.00 21.36  ? 332  TRP A CE2 1 
ATOM   461  C  CE3 . TRP A 1 69  ? -13.624 -61.949 -10.079 1.00 20.98  ? 332  TRP A CE3 1 
ATOM   462  C  CZ2 . TRP A 1 69  ? -12.038 -62.100 -12.401 1.00 24.65  ? 332  TRP A CZ2 1 
ATOM   463  C  CZ3 . TRP A 1 69  ? -13.936 -62.818 -11.102 1.00 21.25  ? 332  TRP A CZ3 1 
ATOM   464  C  CH2 . TRP A 1 69  ? -13.143 -62.898 -12.250 1.00 23.27  ? 332  TRP A CH2 1 
ATOM   465  N  N   . ASP A 1 70  ? -12.269 -60.772 -4.556  1.00 19.89  ? 333  ASP A N   1 
ATOM   466  C  CA  . ASP A 1 70  ? -12.319 -60.349 -3.126  1.00 18.89  ? 333  ASP A CA  1 
ATOM   467  C  C   . ASP A 1 70  ? -10.895 -60.299 -2.520  1.00 20.42  ? 333  ASP A C   1 
ATOM   468  O  O   . ASP A 1 70  ? -10.733 -59.696 -1.436  1.00 21.66  ? 333  ASP A O   1 
ATOM   469  C  CB  . ASP A 1 70  ? -13.228 -61.233 -2.261  1.00 20.31  ? 333  ASP A CB  1 
ATOM   470  C  CG  . ASP A 1 70  ? -14.706 -61.133 -2.602  1.00 21.71  ? 333  ASP A CG  1 
ATOM   471  O  OD1 . ASP A 1 70  ? -15.063 -60.222 -3.375  1.00 22.19  ? 333  ASP A OD1 1 
ATOM   472  O  OD2 . ASP A 1 70  ? -15.481 -61.952 -2.053  1.00 21.21  ? 333  ASP A OD2 1 
ATOM   473  N  N   . ILE A 1 71  ? -9.922  -60.966 -3.125  1.00 22.12  ? 334  ILE A N   1 
ATOM   474  C  CA  . ILE A 1 71  ? -8.528  -61.042 -2.606  1.00 22.98  ? 334  ILE A CA  1 
ATOM   475  C  C   . ILE A 1 71  ? -7.527  -60.328 -3.527  1.00 27.21  ? 334  ILE A C   1 
ATOM   476  O  O   . ILE A 1 71  ? -6.278  -60.522 -3.320  1.00 26.73  ? 334  ILE A O   1 
ATOM   477  C  CB  . ILE A 1 71  ? -8.126  -62.513 -2.350  1.00 25.56  ? 334  ILE A CB  1 
ATOM   478  C  CG1 . ILE A 1 71  ? -8.155  -63.374 -3.616  1.00 26.27  ? 334  ILE A CG1 1 
ATOM   479  C  CG2 . ILE A 1 71  ? -8.966  -63.116 -1.248  1.00 27.22  ? 334  ILE A CG2 1 
ATOM   480  C  CD1 . ILE A 1 71  ? -7.409  -64.699 -3.478  1.00 29.99  ? 334  ILE A CD1 1 
ATOM   481  N  N   . ILE A 1 72  ? -8.012  -59.541 -4.496  0.46 25.56  ? 335  ILE A N   1 
ATOM   482  C  CA  . ILE A 1 72  ? -7.174  -58.747 -5.442  0.46 25.35  ? 335  ILE A CA  1 
ATOM   483  C  C   . ILE A 1 72  ? -7.174  -57.297 -4.971  0.46 26.19  ? 335  ILE A C   1 
ATOM   484  O  O   . ILE A 1 72  ? -8.150  -56.571 -5.181  0.46 23.99  ? 335  ILE A O   1 
ATOM   485  C  CB  . ILE A 1 72  ? -7.701  -58.873 -6.887  0.46 28.24  ? 335  ILE A CB  1 
ATOM   486  C  CG1 . ILE A 1 72  ? -7.791  -60.329 -7.358  0.46 30.24  ? 335  ILE A CG1 1 
ATOM   487  C  CG2 . ILE A 1 72  ? -6.884  -58.006 -7.839  0.46 27.11  ? 335  ILE A CG2 1 
ATOM   488  C  CD1 . ILE A 1 72  ? -6.468  -61.000 -7.589  0.46 33.24  ? 335  ILE A CD1 1 
ATOM   489  N  N   . PRO A 1 73  ? -6.085  -56.814 -4.327  1.00 26.71  ? 336  PRO A N   1 
ATOM   490  C  CA  . PRO A 1 73  ? -6.064  -55.445 -3.799  1.00 28.24  ? 336  PRO A CA  1 
ATOM   491  C  C   . PRO A 1 73  ? -6.335  -54.352 -4.829  1.00 26.47  ? 336  PRO A C   1 
ATOM   492  O  O   . PRO A 1 73  ? -7.025  -53.391 -4.470  1.00 27.32  ? 336  PRO A O   1 
ATOM   493  C  CB  . PRO A 1 73  ? -4.637  -55.283 -3.242  1.00 32.81  ? 336  PRO A CB  1 
ATOM   494  C  CG  . PRO A 1 73  ? -4.235  -56.719 -2.947  1.00 35.54  ? 336  PRO A CG  1 
ATOM   495  C  CD  . PRO A 1 73  ? -4.857  -57.567 -4.057  1.00 28.11  ? 336  PRO A CD  1 
ATOM   496  N  N   . MET A 1 74  ? -5.966  -54.547 -6.095  1.00 26.58  ? 337  MET A N   1 
ATOM   497  C  CA  . MET A 1 74  ? -6.249  -53.498 -7.109  1.00 29.56  ? 337  MET A CA  1 
ATOM   498  C  C   . MET A 1 74  ? -7.770  -53.326 -7.244  1.00 31.86  ? 337  MET A C   1 
ATOM   499  O  O   . MET A 1 74  ? -8.203  -52.203 -7.449  1.00 31.26  ? 337  MET A O   1 
ATOM   500  C  CB  . MET A 1 74  ? -5.624  -53.804 -8.471  1.00 33.31  ? 337  MET A CB  1 
ATOM   501  C  CG  . MET A 1 74  ? -4.086  -53.769 -8.441  1.00 43.09  ? 337  MET A CG  1 
ATOM   502  S  SD  . MET A 1 74  ? -3.467  -52.055 -8.051  1.00 52.66  ? 337  MET A SD  1 
ATOM   503  C  CE  . MET A 1 74  ? -4.575  -51.069 -9.060  1.00 48.32  ? 337  MET A CE  1 
ATOM   504  N  N   . VAL A 1 75  ? -8.554  -54.383 -7.038  1.00 23.17  ? 338  VAL A N   1 
ATOM   505  C  CA  . VAL A 1 75  ? -10.049 -54.278 -7.019  1.00 21.26  ? 338  VAL A CA  1 
ATOM   506  C  C   . VAL A 1 75  ? -10.526 -53.731 -5.688  1.00 23.56  ? 338  VAL A C   1 
ATOM   507  O  O   . VAL A 1 75  ? -11.335 -52.823 -5.703  1.00 27.03  ? 338  VAL A O   1 
ATOM   508  C  CB  . VAL A 1 75  ? -10.704 -55.642 -7.302  1.00 20.57  ? 338  VAL A CB  1 
ATOM   509  C  CG1 . VAL A 1 75  ? -12.197 -55.600 -7.000  1.00 21.86  ? 338  VAL A CG1 1 
ATOM   510  C  CG2 . VAL A 1 75  ? -10.422 -56.061 -8.737  1.00 21.59  ? 338  VAL A CG2 1 
ATOM   511  N  N   . THR A 1 76  ? -10.143 -54.365 -4.593  1.00 23.61  ? 339  THR A N   1 
ATOM   512  C  CA  . THR A 1 76  ? -10.730 -54.098 -3.258  1.00 24.19  ? 339  THR A CA  1 
ATOM   513  C  C   . THR A 1 76  ? -10.370 -52.724 -2.726  1.00 25.28  ? 339  THR A C   1 
ATOM   514  O  O   . THR A 1 76  ? -11.252 -52.085 -2.107  1.00 25.93  ? 339  THR A O   1 
ATOM   515  C  CB  . THR A 1 76  ? -10.337 -55.165 -2.234  1.00 25.35  ? 339  THR A CB  1 
ATOM   516  O  OG1 . THR A 1 76  ? -8.916  -55.152 -2.075  1.00 26.00  ? 339  THR A OG1 1 
ATOM   517  C  CG2 . THR A 1 76  ? -10.832 -56.530 -2.682  1.00 25.77  ? 339  THR A CG2 1 
ATOM   518  N  N   . GLN A 1 77  ? -9.198  -52.209 -3.087  1.00 25.17  ? 340  GLN A N   1 
ATOM   519  C  CA  . GLN A 1 77  ? -8.760  -50.864 -2.625  1.00 30.90  ? 340  GLN A CA  1 
ATOM   520  C  C   . GLN A 1 77  ? -9.545  -49.770 -3.331  1.00 28.81  ? 340  GLN A C   1 
ATOM   521  O  O   . GLN A 1 77  ? -9.642  -48.705 -2.747  1.00 28.24  ? 340  GLN A O   1 
ATOM   522  C  CB  . GLN A 1 77  ? -7.270  -50.608 -2.824  1.00 30.02  ? 340  GLN A CB  1 
ATOM   523  C  CG  . GLN A 1 77  ? -6.402  -51.733 -2.335  1.00 45.03  ? 340  GLN A CG  1 
ATOM   524  C  CD  . GLN A 1 77  ? -5.959  -51.615 -0.906  1.00 57.12  ? 340  GLN A CD  1 
ATOM   525  O  OE1 . GLN A 1 77  ? -6.603  -50.939 -0.102  1.00 65.10  ? 340  GLN A OE1 1 
ATOM   526  N  NE2 . GLN A 1 77  ? -4.855  -52.291 -0.600  1.00 60.59  ? 340  GLN A NE2 1 
ATOM   527  N  N   . MET A 1 78  ? -10.081 -50.024 -4.521  1.00 26.60  ? 341  MET A N   1 
ATOM   528  C  CA  . MET A 1 78  ? -10.849 -49.001 -5.272  1.00 28.81  ? 341  MET A CA  1 
ATOM   529  C  C   . MET A 1 78  ? -12.091 -48.554 -4.499  1.00 27.93  ? 341  MET A C   1 
ATOM   530  O  O   . MET A 1 78  ? -12.492 -47.398 -4.701  1.00 25.57  ? 341  MET A O   1 
ATOM   531  C  CB  . MET A 1 78  ? -11.302 -49.454 -6.662  1.00 29.94  ? 341  MET A CB  1 
ATOM   532  C  CG  . MET A 1 78  ? -10.173 -49.731 -7.610  1.00 40.88  ? 341  MET A CG  1 
ATOM   533  S  SD  . MET A 1 78  ? -10.779 -50.054 -9.329  1.00 40.96  ? 341  MET A SD  1 
ATOM   534  C  CE  . MET A 1 78  ? -12.105 -48.856 -9.328  1.00 31.89  ? 341  MET A CE  1 
ATOM   535  N  N   . ALA A 1 79  ? -12.684 -49.394 -3.629  1.00 26.42  ? 342  ALA A N   1 
ATOM   536  C  CA  . ALA A 1 79  ? -13.919 -49.043 -2.880  1.00 29.30  ? 342  ALA A CA  1 
ATOM   537  C  C   . ALA A 1 79  ? -13.599 -48.311 -1.565  1.00 31.15  ? 342  ALA A C   1 
ATOM   538  O  O   . ALA A 1 79  ? -14.540 -47.855 -0.937  1.00 31.75  ? 342  ALA A O   1 
ATOM   539  C  CB  . ALA A 1 79  ? -14.737 -50.301 -2.632  1.00 32.53  ? 342  ALA A CB  1 
ATOM   540  N  N   . MET A 1 80  ? -12.338 -48.191 -1.142  1.00 32.39  ? 343  MET A N   1 
ATOM   541  C  CA  . MET A 1 80  ? -11.988 -47.605 0.192   1.00 38.59  ? 343  MET A CA  1 
ATOM   542  C  C   . MET A 1 80  ? -11.905 -46.066 0.122   1.00 50.33  ? 343  MET A C   1 
ATOM   543  O  O   . MET A 1 80  ? -11.679 -45.550 -0.968  1.00 50.92  ? 343  MET A O   1 
ATOM   544  C  CB  . MET A 1 80  ? -10.645 -48.162 0.696   1.00 35.59  ? 343  MET A CB  1 
ATOM   545  C  CG  . MET A 1 80  ? -10.633 -49.693 0.837   1.00 38.54  ? 343  MET A CG  1 
ATOM   546  S  SD  . MET A 1 80  ? -12.073 -50.411 1.788   1.00 44.35  ? 343  MET A SD  1 
ATOM   547  C  CE  . MET A 1 80  ? -11.579 -50.058 3.475   1.00 42.46  ? 343  MET A CE  1 
ATOM   548  N  N   . THR A 1 81  ? -12.062 -45.367 1.261   1.00 69.47  ? 344  THR A N   1 
ATOM   549  C  CA  . THR A 1 81  ? -11.542 -43.994 1.499   1.00 69.36  ? 344  THR A CA  1 
ATOM   550  C  C   . THR A 1 81  ? -12.624 -42.928 1.543   1.00 61.63  ? 344  THR A C   1 
ATOM   551  O  O   . THR A 1 81  ? -13.815 -43.309 1.517   1.00 66.50  ? 344  THR A O   1 
ATOM   552  N  N   . LYS A 1 93  ? -6.982  -27.701 -3.698  0.50 133.72 ? 356  LYS A N   1 
ATOM   553  C  CA  . LYS A 1 93  ? -6.443  -29.059 -3.978  0.50 133.92 ? 356  LYS A CA  1 
ATOM   554  C  C   . LYS A 1 93  ? -4.959  -28.949 -4.340  0.50 133.08 ? 356  LYS A C   1 
ATOM   555  O  O   . LYS A 1 93  ? -4.406  -29.956 -4.822  0.50 130.77 ? 356  LYS A O   1 
ATOM   556  C  CB  . LYS A 1 93  ? -7.240  -29.728 -5.100  0.50 134.62 ? 356  LYS A CB  1 
ATOM   557  C  CG  . LYS A 1 93  ? -7.270  -28.960 -6.415  0.50 136.29 ? 356  LYS A CG  1 
ATOM   558  C  CD  . LYS A 1 93  ? -8.101  -29.636 -7.483  0.50 135.99 ? 356  LYS A CD  1 
ATOM   559  C  CE  . LYS A 1 93  ? -7.596  -31.017 -7.841  0.50 134.41 ? 356  LYS A CE  1 
ATOM   560  N  NZ  . LYS A 1 93  ? -8.406  -31.631 -8.918  0.50 132.46 ? 356  LYS A NZ  1 
ATOM   561  N  N   . GLU A 1 94  ? -4.358  -27.772 -4.139  0.50 131.70 ? 357  GLU A N   1 
ATOM   562  C  CA  . GLU A 1 94  ? -2.902  -27.575 -4.393  0.50 128.20 ? 357  GLU A CA  1 
ATOM   563  C  C   . GLU A 1 94  ? -2.640  -27.410 -5.895  0.50 121.97 ? 357  GLU A C   1 
ATOM   564  O  O   . GLU A 1 94  ? -1.530  -26.969 -6.244  0.50 116.41 ? 357  GLU A O   1 
ATOM   565  C  CB  . GLU A 1 94  ? -2.087  -28.714 -3.777  0.50 131.68 ? 357  GLU A CB  1 
ATOM   566  C  CG  . GLU A 1 94  ? -2.037  -28.662 -2.261  0.50 136.27 ? 357  GLU A CG  1 
ATOM   567  C  CD  . GLU A 1 94  ? -3.371  -28.879 -1.567  0.50 141.07 ? 357  GLU A CD  1 
ATOM   568  O  OE1 . GLU A 1 94  ? -3.782  -27.996 -0.788  0.50 141.29 ? 357  GLU A OE1 1 
ATOM   569  O  OE2 . GLU A 1 94  ? -3.991  -29.936 -1.800  0.50 147.56 ? 357  GLU A OE2 1 
ATOM   570  N  N   . LYS A 1 95  ? -3.613  -27.752 -6.746  1.00 119.85 ? 358  LYS A N   1 
ATOM   571  C  CA  . LYS A 1 95  ? -3.460  -27.517 -8.209  1.00 114.34 ? 358  LYS A CA  1 
ATOM   572  C  C   . LYS A 1 95  ? -4.352  -26.344 -8.601  1.00 105.61 ? 358  LYS A C   1 
ATOM   573  O  O   . LYS A 1 95  ? -3.961  -25.564 -9.481  1.00 85.19  ? 358  LYS A O   1 
ATOM   574  C  CB  . LYS A 1 95  ? -3.872  -28.750 -9.012  1.00 114.95 ? 358  LYS A CB  1 
ATOM   575  C  CG  . LYS A 1 95  ? -3.532  -28.712 -10.495 1.00 110.52 ? 358  LYS A CG  1 
ATOM   576  C  CD  . LYS A 1 95  ? -2.067  -28.959 -10.767 1.00 104.70 ? 358  LYS A CD  1 
ATOM   577  C  CE  . LYS A 1 95  ? -1.706  -28.885 -12.234 1.00 102.61 ? 358  LYS A CE  1 
ATOM   578  N  NZ  . LYS A 1 95  ? -0.300  -29.287 -12.464 1.00 100.95 ? 358  LYS A NZ  1 
ATOM   579  N  N   . VAL A 1 96  ? -5.509  -26.230 -7.947  1.00 105.73 ? 359  VAL A N   1 
ATOM   580  C  CA  . VAL A 1 96  ? -6.430  -25.093 -8.236  1.00 105.54 ? 359  VAL A CA  1 
ATOM   581  C  C   . VAL A 1 96  ? -5.753  -23.782 -7.813  1.00 104.22 ? 359  VAL A C   1 
ATOM   582  O  O   . VAL A 1 96  ? -5.961  -22.774 -8.501  1.00 102.02 ? 359  VAL A O   1 
ATOM   583  C  CB  . VAL A 1 96  ? -7.799  -25.282 -7.556  1.00 102.89 ? 359  VAL A CB  1 
ATOM   584  C  CG1 . VAL A 1 96  ? -7.695  -25.182 -6.043  1.00 106.98 ? 359  VAL A CG1 1 
ATOM   585  C  CG2 . VAL A 1 96  ? -8.831  -24.301 -8.087  1.00 96.04  ? 359  VAL A CG2 1 
ATOM   586  N  N   . ASP A 1 97  ? -4.989  -23.797 -6.718  1.00 96.48  ? 360  ASP A N   1 
ATOM   587  C  CA  . ASP A 1 97  ? -4.357  -22.551 -6.217  1.00 90.52  ? 360  ASP A CA  1 
ATOM   588  C  C   . ASP A 1 97  ? -3.033  -22.344 -6.962  1.00 95.19  ? 360  ASP A C   1 
ATOM   589  O  O   . ASP A 1 97  ? -2.003  -22.159 -6.288  1.00 99.85  ? 360  ASP A O   1 
ATOM   590  C  CB  . ASP A 1 97  ? -4.235  -22.572 -4.686  1.00 82.91  ? 360  ASP A CB  1 
ATOM   591  C  CG  . ASP A 1 97  ? -4.404  -21.216 -4.021  1.00 81.66  ? 360  ASP A CG  1 
ATOM   592  O  OD1 . ASP A 1 97  ? -4.239  -20.196 -4.712  1.00 72.37  ? 360  ASP A OD1 1 
ATOM   593  O  OD2 . ASP A 1 97  ? -4.706  -21.196 -2.814  1.00 82.90  ? 360  ASP A OD2 1 
ATOM   594  N  N   . THR A 1 98  ? -3.064  -22.359 -8.298  1.00 92.31  ? 361  THR A N   1 
ATOM   595  C  CA  . THR A 1 98  ? -1.840  -22.139 -9.113  1.00 94.59  ? 361  THR A CA  1 
ATOM   596  C  C   . THR A 1 98  ? -2.074  -20.970 -10.072 1.00 93.12  ? 361  THR A C   1 
ATOM   597  O  O   . THR A 1 98  ? -3.232  -20.560 -10.208 1.00 87.43  ? 361  THR A O   1 
ATOM   598  C  CB  . THR A 1 98  ? -1.436  -23.415 -9.864  1.00 94.74  ? 361  THR A CB  1 
ATOM   599  O  OG1 . THR A 1 98  ? -2.555  -23.847 -10.639 1.00 91.51  ? 361  THR A OG1 1 
ATOM   600  C  CG2 . THR A 1 98  ? -0.996  -24.527 -8.938  1.00 93.11  ? 361  THR A CG2 1 
ATOM   601  N  N   . ARG A 1 99  ? -1.012  -20.463 -10.708 0.50 95.71  ? 362  ARG A N   1 
ATOM   602  C  CA  . ARG A 1 99  ? -1.145  -19.301 -11.629 0.50 99.88  ? 362  ARG A CA  1 
ATOM   603  C  C   . ARG A 1 99  ? -0.368  -19.548 -12.928 0.50 100.30 ? 362  ARG A C   1 
ATOM   604  O  O   . ARG A 1 99  ? 0.872   -19.634 -12.865 0.50 104.13 ? 362  ARG A O   1 
ATOM   605  C  CB  . ARG A 1 99  ? -0.654  -18.016 -10.958 0.50 103.27 ? 362  ARG A CB  1 
ATOM   606  C  CG  . ARG A 1 99  ? -1.377  -16.763 -11.430 0.50 106.87 ? 362  ARG A CG  1 
ATOM   607  C  CD  . ARG A 1 99  ? -0.493  -15.531 -11.459 0.50 109.97 ? 362  ARG A CD  1 
ATOM   608  N  NE  . ARG A 1 99  ? 0.415   -15.535 -12.598 0.50 112.34 ? 362  ARG A NE  1 
ATOM   609  C  CZ  . ARG A 1 99  ? 1.233   -14.538 -12.913 0.50 109.16 ? 362  ARG A CZ  1 
ATOM   610  N  NH1 . ARG A 1 99  ? 1.262   -13.446 -12.169 0.50 108.69 ? 362  ARG A NH1 1 
ATOM   611  N  NH2 . ARG A 1 99  ? 2.019   -14.637 -13.970 0.50 107.29 ? 362  ARG A NH2 1 
ATOM   612  N  N   . THR A 1 100 ? -1.071  -19.644 -14.058 1.00 98.36  ? 363  THR A N   1 
ATOM   613  C  CA  . THR A 1 100 ? -0.418  -19.825 -15.390 1.00 94.52  ? 363  THR A CA  1 
ATOM   614  C  C   . THR A 1 100 ? -0.001  -18.449 -15.912 1.00 85.98  ? 363  THR A C   1 
ATOM   615  O  O   . THR A 1 100 ? -0.796  -17.515 -15.756 1.00 90.44  ? 363  THR A O   1 
ATOM   616  C  CB  . THR A 1 100 ? -1.332  -20.525 -16.407 1.00 98.99  ? 363  THR A CB  1 
ATOM   617  O  OG1 . THR A 1 100 ? -1.545  -21.874 -15.985 1.00 99.14  ? 363  THR A OG1 1 
ATOM   618  C  CG2 . THR A 1 100 ? -0.763  -20.543 -17.811 1.00 98.81  ? 363  THR A CG2 1 
ATOM   619  N  N   . GLN A 1 101 ? 1.187   -18.344 -16.517 1.00 86.04  ? 364  GLN A N   1 
ATOM   620  C  CA  . GLN A 1 101 ? 1.760   -17.066 -17.024 1.00 83.25  ? 364  GLN A CA  1 
ATOM   621  C  C   . GLN A 1 101 ? 1.018   -16.636 -18.300 1.00 78.44  ? 364  GLN A C   1 
ATOM   622  O  O   . GLN A 1 101 ? 0.403   -17.487 -18.955 1.00 76.32  ? 364  GLN A O   1 
ATOM   623  C  CB  . GLN A 1 101 ? 3.269   -17.204 -17.264 1.00 80.86  ? 364  GLN A CB  1 
ATOM   624  C  CG  . GLN A 1 101 ? 3.878   -15.999 -17.973 1.00 86.73  ? 364  GLN A CG  1 
ATOM   625  C  CD  . GLN A 1 101 ? 5.382   -15.903 -17.885 1.00 91.66  ? 364  GLN A CD  1 
ATOM   626  O  OE1 . GLN A 1 101 ? 6.096   -16.904 -17.932 1.00 93.53  ? 364  GLN A OE1 1 
ATOM   627  N  NE2 . GLN A 1 101 ? 5.877   -14.679 -17.778 1.00 88.43  ? 364  GLN A NE2 1 
ATOM   628  N  N   . GLU A 1 102 ? 1.075   -15.344 -18.618 1.00 74.02  ? 365  GLU A N   1 
ATOM   629  C  CA  . GLU A 1 102 ? 0.582   -14.729 -19.878 1.00 71.05  ? 365  GLU A CA  1 
ATOM   630  C  C   . GLU A 1 102 ? 1.381   -15.271 -21.069 1.00 61.80  ? 365  GLU A C   1 
ATOM   631  O  O   . GLU A 1 102 ? 2.606   -15.187 -21.108 1.00 55.87  ? 365  GLU A O   1 
ATOM   632  C  CB  . GLU A 1 102 ? 0.691   -13.205 -19.727 1.00 76.23  ? 365  GLU A CB  1 
ATOM   633  C  CG  . GLU A 1 102 ? 0.268   -12.399 -20.948 1.00 87.95  ? 365  GLU A CG  1 
ATOM   634  C  CD  . GLU A 1 102 ? -1.204  -12.029 -21.030 1.00 93.97  ? 365  GLU A CD  1 
ATOM   635  O  OE1 . GLU A 1 102 ? -1.494  -10.834 -21.255 1.00 101.32 ? 365  GLU A OE1 1 
ATOM   636  O  OE2 . GLU A 1 102 ? -2.054  -12.937 -20.900 1.00 90.61  ? 365  GLU A OE2 1 
ATOM   637  N  N   . PRO A 1 103 ? 0.735   -15.846 -22.107 1.00 57.06  ? 366  PRO A N   1 
ATOM   638  C  CA  . PRO A 1 103 ? 1.467   -16.254 -23.303 1.00 54.01  ? 366  PRO A CA  1 
ATOM   639  C  C   . PRO A 1 103 ? 2.156   -15.054 -23.968 1.00 55.29  ? 366  PRO A C   1 
ATOM   640  O  O   . PRO A 1 103 ? 1.636   -13.979 -23.835 1.00 49.82  ? 366  PRO A O   1 
ATOM   641  C  CB  . PRO A 1 103 ? 0.369   -16.834 -24.212 1.00 56.49  ? 366  PRO A CB  1 
ATOM   642  C  CG  . PRO A 1 103 ? -0.717  -17.260 -23.245 1.00 53.70  ? 366  PRO A CG  1 
ATOM   643  C  CD  . PRO A 1 103 ? -0.698  -16.180 -22.184 1.00 55.71  ? 366  PRO A CD  1 
ATOM   644  N  N   . LYS A 1 104 ? 3.263   -15.289 -24.680 1.00 51.52  ? 367  LYS A N   1 
ATOM   645  C  CA  . LYS A 1 104 ? 3.947   -14.303 -25.569 1.00 55.53  ? 367  LYS A CA  1 
ATOM   646  C  C   . LYS A 1 104 ? 2.986   -13.806 -26.660 1.00 53.01  ? 367  LYS A C   1 
ATOM   647  O  O   . LYS A 1 104 ? 1.956   -14.459 -26.923 1.00 43.72  ? 367  LYS A O   1 
ATOM   648  C  CB  . LYS A 1 104 ? 5.155   -14.916 -26.302 1.00 61.82  ? 367  LYS A CB  1 
ATOM   649  C  CG  . LYS A 1 104 ? 6.255   -15.559 -25.458 1.00 64.15  ? 367  LYS A CG  1 
ATOM   650  C  CD  . LYS A 1 104 ? 6.386   -14.952 -24.097 1.00 67.00  ? 367  LYS A CD  1 
ATOM   651  C  CE  . LYS A 1 104 ? 7.629   -15.376 -23.351 1.00 67.36  ? 367  LYS A CE  1 
ATOM   652  N  NZ  . LYS A 1 104 ? 7.459   -15.047 -21.916 1.00 71.44  ? 367  LYS A NZ  1 
ATOM   653  N  N   . GLU A 1 105 ? 3.379   -12.744 -27.360 1.00 46.94  ? 368  GLU A N   1 
ATOM   654  C  CA  . GLU A 1 105 ? 2.542   -12.046 -28.362 1.00 50.64  ? 368  GLU A CA  1 
ATOM   655  C  C   . GLU A 1 105 ? 2.384   -12.912 -29.614 1.00 46.72  ? 368  GLU A C   1 
ATOM   656  O  O   . GLU A 1 105 ? 1.270   -12.930 -30.162 1.00 48.60  ? 368  GLU A O   1 
ATOM   657  C  CB  . GLU A 1 105 ? 3.153   -10.676 -28.695 1.00 59.60  ? 368  GLU A CB  1 
ATOM   658  C  CG  . GLU A 1 105 ? 3.156   -9.710  -27.514 1.00 60.54  ? 368  GLU A CG  1 
ATOM   659  C  CD  . GLU A 1 105 ? 1.793   -9.379  -26.922 1.00 60.77  ? 368  GLU A CD  1 
ATOM   660  O  OE1 . GLU A 1 105 ? 0.863   -9.091  -27.704 1.00 78.59  ? 368  GLU A OE1 1 
ATOM   661  O  OE2 . GLU A 1 105 ? 1.655   -9.415  -25.687 1.00 60.24  ? 368  GLU A OE2 1 
ATOM   662  N  N   . GLY A 1 106 ? 3.436   -13.613 -30.054 1.00 42.93  ? 369  GLY A N   1 
ATOM   663  C  CA  . GLY A 1 106 ? 3.336   -14.540 -31.197 1.00 38.50  ? 369  GLY A CA  1 
ATOM   664  C  C   . GLY A 1 106 ? 2.379   -15.704 -30.868 1.00 38.60  ? 369  GLY A C   1 
ATOM   665  O  O   . GLY A 1 106 ? 1.613   -16.088 -31.781 1.00 41.26  ? 369  GLY A O   1 
ATOM   666  N  N   . THR A 1 107 ? 2.421   -16.229 -29.630 1.00 37.47  ? 370  THR A N   1 
ATOM   667  C  CA  . THR A 1 107 ? 1.518   -17.312 -29.127 1.00 39.75  ? 370  THR A CA  1 
ATOM   668  C  C   . THR A 1 107 ? 0.055   -16.839 -29.134 1.00 43.43  ? 370  THR A C   1 
ATOM   669  O  O   . THR A 1 107 ? -0.793  -17.527 -29.745 1.00 41.42  ? 370  THR A O   1 
ATOM   670  C  CB  . THR A 1 107 ? 1.919   -17.812 -27.739 1.00 41.52  ? 370  THR A CB  1 
ATOM   671  O  OG1 . THR A 1 107 ? 3.336   -18.013 -27.730 1.00 43.60  ? 370  THR A OG1 1 
ATOM   672  C  CG2 . THR A 1 107 ? 1.225   -19.116 -27.389 1.00 40.27  ? 370  THR A CG2 1 
ATOM   673  N  N   . LYS A 1 108 ? -0.240  -15.682 -28.533 1.00 42.31  ? 371  LYS A N   1 
ATOM   674  C  CA  . LYS A 1 108 ? -1.583  -15.016 -28.580 1.00 42.25  ? 371  LYS A CA  1 
ATOM   675  C  C   . LYS A 1 108 ? -2.097  -14.809 -30.015 1.00 41.66  ? 371  LYS A C   1 
ATOM   676  O  O   . LYS A 1 108 ? -3.298  -15.062 -30.256 1.00 39.78  ? 371  LYS A O   1 
ATOM   677  C  CB  . LYS A 1 108 ? -1.506  -13.701 -27.796 1.00 46.59  ? 371  LYS A CB  1 
ATOM   678  C  CG  . LYS A 1 108 ? -1.275  -13.894 -26.307 1.00 48.58  ? 371  LYS A CG  1 
ATOM   679  C  CD  . LYS A 1 108 ? -1.706  -12.724 -25.448 1.00 54.99  ? 371  LYS A CD  1 
ATOM   680  C  CE  . LYS A 1 108 ? -0.687  -11.608 -25.398 1.00 63.38  ? 371  LYS A CE  1 
ATOM   681  N  NZ  . LYS A 1 108 ? -0.761  -10.878 -24.107 1.00 69.50  ? 371  LYS A NZ  1 
ATOM   682  N  N   . LYS A 1 109 ? -1.248  -14.370 -30.950 1.00 39.12  ? 372  LYS A N   1 
ATOM   683  C  CA  . LYS A 1 109 ? -1.631  -14.214 -32.375 1.00 39.91  ? 372  LYS A CA  1 
ATOM   684  C  C   . LYS A 1 109 ? -2.020  -15.569 -32.989 1.00 42.01  ? 372  LYS A C   1 
ATOM   685  O  O   . LYS A 1 109 ? -3.023  -15.601 -33.741 1.00 41.02  ? 372  LYS A O   1 
ATOM   686  C  CB  . LYS A 1 109 ? -0.481  -13.623 -33.189 1.00 47.20  ? 372  LYS A CB  1 
ATOM   687  C  CG  . LYS A 1 109 ? -0.834  -13.144 -34.589 1.00 58.72  ? 372  LYS A CG  1 
ATOM   688  C  CD  . LYS A 1 109 ? -1.997  -12.141 -34.645 1.00 64.75  ? 372  LYS A CD  1 
ATOM   689  C  CE  . LYS A 1 109 ? -1.777  -10.906 -33.802 1.00 65.92  ? 372  LYS A CE  1 
ATOM   690  N  NZ  . LYS A 1 109 ? -2.847  -9.906  -34.034 1.00 71.00  ? 372  LYS A NZ  1 
ATOM   691  N  N   . LEU A 1 110 ? -1.195  -16.614 -32.790 1.00 40.69  ? 373  LEU A N   1 
ATOM   692  C  CA  . LEU A 1 110 ? -1.451  -17.990 -33.323 1.00 39.84  ? 373  LEU A CA  1 
ATOM   693  C  C   . LEU A 1 110 ? -2.811  -18.475 -32.801 1.00 31.02  ? 373  LEU A C   1 
ATOM   694  O  O   . LEU A 1 110 ? -3.591  -18.982 -33.607 1.00 33.47  ? 373  LEU A O   1 
ATOM   695  C  CB  . LEU A 1 110 ? -0.334  -18.953 -32.895 1.00 39.54  ? 373  LEU A CB  1 
ATOM   696  C  CG  . LEU A 1 110 ? 1.006   -18.736 -33.604 1.00 38.95  ? 373  LEU A CG  1 
ATOM   697  C  CD1 . LEU A 1 110 ? 2.176   -19.341 -32.830 1.00 37.07  ? 373  LEU A CD1 1 
ATOM   698  C  CD2 . LEU A 1 110 ? 0.942   -19.274 -35.039 1.00 41.99  ? 373  LEU A CD2 1 
ATOM   699  N  N   . MET A 1 111 ? -3.075  -18.296 -31.519 1.00 30.70  ? 374  MET A N   1 
ATOM   700  C  CA  . MET A 1 111 ? -4.333  -18.768 -30.877 1.00 30.56  ? 374  MET A CA  1 
ATOM   701  C  C   . MET A 1 111 ? -5.544  -17.998 -31.433 1.00 36.01  ? 374  MET A C   1 
ATOM   702  O  O   . MET A 1 111 ? -6.561  -18.658 -31.704 1.00 30.03  ? 374  MET A O   1 
ATOM   703  C  CB  . MET A 1 111 ? -4.260  -18.611 -29.356 1.00 31.37  ? 374  MET A CB  1 
ATOM   704  C  CG  . MET A 1 111 ? -3.242  -19.579 -28.739 1.00 32.66  ? 374  MET A CG  1 
ATOM   705  S  SD  . MET A 1 111 ? -3.348  -19.773 -26.963 1.00 38.98  ? 374  MET A SD  1 
ATOM   706  C  CE  . MET A 1 111 ? -2.880  -18.136 -26.410 1.00 37.97  ? 374  MET A CE  1 
ATOM   707  N  N   . LYS A 1 112 ? -5.445  -16.670 -31.635 1.00 34.89  ? 375  LYS A N   1 
ATOM   708  C  CA  . LYS A 1 112 ? -6.591  -15.841 -32.102 1.00 37.58  ? 375  LYS A CA  1 
ATOM   709  C  C   . LYS A 1 112 ? -6.887  -16.200 -33.555 1.00 34.83  ? 375  LYS A C   1 
ATOM   710  O  O   . LYS A 1 112 ? -8.075  -16.405 -33.881 1.00 37.07  ? 375  LYS A O   1 
ATOM   711  C  CB  . LYS A 1 112 ? -6.304  -14.334 -31.978 1.00 47.26  ? 375  LYS A CB  1 
ATOM   712  C  CG  . LYS A 1 112 ? -7.426  -13.471 -31.397 1.00 57.76  ? 375  LYS A CG  1 
ATOM   713  C  CD  . LYS A 1 112 ? -7.267  -13.235 -29.884 1.00 65.19  ? 375  LYS A CD  1 
ATOM   714  C  CE  . LYS A 1 112 ? -8.528  -12.837 -29.138 1.00 69.93  ? 375  LYS A CE  1 
ATOM   715  N  NZ  . LYS A 1 112 ? -8.384  -13.084 -27.679 1.00 69.35  ? 375  LYS A NZ  1 
ATOM   716  N  N   . ILE A 1 113 ? -5.859  -16.287 -34.406 1.00 33.38  ? 376  ILE A N   1 
ATOM   717  C  CA  . ILE A 1 113 ? -6.051  -16.679 -35.839 1.00 36.21  ? 376  ILE A CA  1 
ATOM   718  C  C   . ILE A 1 113 ? -6.660  -18.082 -35.899 1.00 35.90  ? 376  ILE A C   1 
ATOM   719  O  O   . ILE A 1 113 ? -7.609  -18.294 -36.739 1.00 35.89  ? 376  ILE A O   1 
ATOM   720  C  CB  . ILE A 1 113 ? -4.753  -16.640 -36.668 1.00 35.82  ? 376  ILE A CB  1 
ATOM   721  C  CG1 . ILE A 1 113 ? -4.198  -15.223 -36.841 1.00 44.88  ? 376  ILE A CG1 1 
ATOM   722  C  CG2 . ILE A 1 113 ? -4.918  -17.304 -38.024 1.00 36.12  ? 376  ILE A CG2 1 
ATOM   723  C  CD1 . ILE A 1 113 ? -2.747  -15.229 -37.249 1.00 46.98  ? 376  ILE A CD1 1 
ATOM   724  N  N   . THR A 1 114 ? -6.115  -19.035 -35.119 1.00 34.99  ? 377  THR A N   1 
ATOM   725  C  CA  . THR A 1 114 ? -6.601  -20.454 -35.178 1.00 30.27  ? 377  THR A CA  1 
ATOM   726  C  C   . THR A 1 114 ? -8.036  -20.556 -34.649 1.00 26.31  ? 377  THR A C   1 
ATOM   727  O  O   . THR A 1 114 ? -8.867  -21.254 -35.283 1.00 29.42  ? 377  THR A O   1 
ATOM   728  C  CB  . THR A 1 114 ? -5.679  -21.416 -34.429 1.00 31.13  ? 377  THR A CB  1 
ATOM   729  O  OG1 . THR A 1 114 ? -4.387  -21.199 -34.973 1.00 28.24  ? 377  THR A OG1 1 
ATOM   730  C  CG2 . THR A 1 114 ? -6.041  -22.867 -34.656 1.00 31.06  ? 377  THR A CG2 1 
ATOM   731  N  N   . ALA A 1 115 ? -8.343  -19.905 -33.531 1.00 30.90  ? 378  ALA A N   1 
ATOM   732  C  CA  . ALA A 1 115 ? -9.697  -19.934 -32.928 1.00 31.12  ? 378  ALA A CA  1 
ATOM   733  C  C   . ALA A 1 115 ? -10.728 -19.326 -33.890 1.00 34.67  ? 378  ALA A C   1 
ATOM   734  O  O   . ALA A 1 115 ? -11.841 -19.908 -34.062 1.00 30.12  ? 378  ALA A O   1 
ATOM   735  C  CB  . ALA A 1 115 ? -9.707  -19.209 -31.626 1.00 32.94  ? 378  ALA A CB  1 
ATOM   736  N  N   . GLU A 1 116 ? -10.376 -18.209 -34.533 1.00 32.65  ? 379  GLU A N   1 
ATOM   737  C  CA  . GLU A 1 116 ? -11.287 -17.523 -35.490 1.00 36.17  ? 379  GLU A CA  1 
ATOM   738  C  C   . GLU A 1 116 ? -11.636 -18.512 -36.607 1.00 35.64  ? 379  GLU A C   1 
ATOM   739  O  O   . GLU A 1 116 ? -12.817 -18.727 -36.897 1.00 33.35  ? 379  GLU A O   1 
ATOM   740  C  CB  . GLU A 1 116 ? -10.650 -16.217 -35.986 1.00 38.43  ? 379  GLU A CB  1 
ATOM   741  C  CG  . GLU A 1 116 ? -11.441 -15.540 -37.089 1.00 50.77  ? 379  GLU A CG  1 
ATOM   742  C  CD  . GLU A 1 116 ? -10.815 -14.282 -37.687 1.00 55.11  ? 379  GLU A CD  1 
ATOM   743  O  OE1 . GLU A 1 116 ? -9.550  -14.187 -37.735 1.00 55.52  ? 379  GLU A OE1 1 
ATOM   744  O  OE2 . GLU A 1 116 ? -11.598 -13.418 -38.127 1.00 65.09  ? 379  GLU A OE2 1 
ATOM   745  N  N   . TRP A 1 117 ? -10.631 -19.149 -37.181 1.00 32.37  ? 380  TRP A N   1 
ATOM   746  C  CA  . TRP A 1 117 ? -10.806 -20.102 -38.280 1.00 30.21  ? 380  TRP A CA  1 
ATOM   747  C  C   . TRP A 1 117 ? -11.614 -21.321 -37.780 1.00 34.41  ? 380  TRP A C   1 
ATOM   748  O  O   . TRP A 1 117 ? -12.441 -21.866 -38.552 1.00 29.17  ? 380  TRP A O   1 
ATOM   749  C  CB  . TRP A 1 117 ? -9.429  -20.483 -38.773 1.00 33.65  ? 380  TRP A CB  1 
ATOM   750  C  CG  . TRP A 1 117 ? -9.506  -21.543 -39.799 1.00 28.04  ? 380  TRP A CG  1 
ATOM   751  C  CD1 . TRP A 1 117 ? -9.693  -21.354 -41.123 1.00 29.69  ? 380  TRP A CD1 1 
ATOM   752  C  CD2 . TRP A 1 117 ? -9.500  -22.956 -39.572 1.00 29.66  ? 380  TRP A CD2 1 
ATOM   753  N  NE1 . TRP A 1 117 ? -9.698  -22.553 -41.756 1.00 33.13  ? 380  TRP A NE1 1 
ATOM   754  C  CE2 . TRP A 1 117 ? -9.561  -23.560 -40.831 1.00 28.47  ? 380  TRP A CE2 1 
ATOM   755  C  CE3 . TRP A 1 117 ? -9.318  -23.769 -38.452 1.00 31.25  ? 380  TRP A CE3 1 
ATOM   756  C  CZ2 . TRP A 1 117 ? -9.543  -24.945 -41.001 1.00 31.52  ? 380  TRP A CZ2 1 
ATOM   757  C  CZ3 . TRP A 1 117 ? -9.259  -25.134 -38.619 1.00 27.14  ? 380  TRP A CZ3 1 
ATOM   758  C  CH2 . TRP A 1 117 ? -9.404  -25.717 -39.868 1.00 29.29  ? 380  TRP A CH2 1 
ATOM   759  N  N   . LEU A 1 118 ? -11.417 -21.748 -36.529 1.00 30.64  ? 381  LEU A N   1 
ATOM   760  C  CA  . LEU A 1 118 ? -12.034 -23.025 -36.062 1.00 29.46  ? 381  LEU A CA  1 
ATOM   761  C  C   . LEU A 1 118 ? -13.531 -22.798 -35.786 1.00 26.77  ? 381  LEU A C   1 
ATOM   762  O  O   . LEU A 1 118 ? -14.319 -23.612 -36.242 1.00 28.35  ? 381  LEU A O   1 
ATOM   763  C  CB  . LEU A 1 118 ? -11.293 -23.520 -34.822 1.00 30.96  ? 381  LEU A CB  1 
ATOM   764  C  CG  . LEU A 1 118 ? -11.699 -24.910 -34.325 1.00 31.78  ? 381  LEU A CG  1 
ATOM   765  C  CD1 . LEU A 1 118 ? -11.535 -25.972 -35.393 1.00 31.58  ? 381  LEU A CD1 1 
ATOM   766  C  CD2 . LEU A 1 118 ? -10.888 -25.255 -33.085 1.00 34.32  ? 381  LEU A CD2 1 
ATOM   767  N  N   . TRP A 1 119 ? -13.920 -21.699 -35.136 1.00 27.11  ? 382  TRP A N   1 
ATOM   768  C  CA  . TRP A 1 119 ? -15.375 -21.410 -34.938 1.00 32.47  ? 382  TRP A CA  1 
ATOM   769  C  C   . TRP A 1 119 ? -16.094 -21.280 -36.288 1.00 33.36  ? 382  TRP A C   1 
ATOM   770  O  O   . TRP A 1 119 ? -17.197 -21.867 -36.459 1.00 34.39  ? 382  TRP A O   1 
ATOM   771  C  CB  . TRP A 1 119 ? -15.566 -20.156 -34.116 1.00 32.11  ? 382  TRP A CB  1 
ATOM   772  C  CG  . TRP A 1 119 ? -15.328 -20.355 -32.667 1.00 28.03  ? 382  TRP A CG  1 
ATOM   773  C  CD1 . TRP A 1 119 ? -14.525 -19.606 -31.873 1.00 29.11  ? 382  TRP A CD1 1 
ATOM   774  C  CD2 . TRP A 1 119 ? -15.952 -21.324 -31.808 1.00 28.63  ? 382  TRP A CD2 1 
ATOM   775  N  NE1 . TRP A 1 119 ? -14.618 -20.014 -30.576 1.00 27.61  ? 382  TRP A NE1 1 
ATOM   776  C  CE2 . TRP A 1 119 ? -15.481 -21.072 -30.511 1.00 25.60  ? 382  TRP A CE2 1 
ATOM   777  C  CE3 . TRP A 1 119 ? -16.913 -22.322 -31.989 1.00 30.52  ? 382  TRP A CE3 1 
ATOM   778  C  CZ2 . TRP A 1 119 ? -15.851 -21.844 -29.419 1.00 27.41  ? 382  TRP A CZ2 1 
ATOM   779  C  CZ3 . TRP A 1 119 ? -17.295 -23.067 -30.900 1.00 27.29  ? 382  TRP A CZ3 1 
ATOM   780  C  CH2 . TRP A 1 119 ? -16.766 -22.831 -29.645 1.00 26.55  ? 382  TRP A CH2 1 
ATOM   781  N  N   . LYS A 1 120 ? -15.451 -20.656 -37.282 1.00 34.30  ? 383  LYS A N   1 
ATOM   782  C  CA  . LYS A 1 120 ? -16.028 -20.594 -38.648 1.00 35.25  ? 383  LYS A CA  1 
ATOM   783  C  C   . LYS A 1 120 ? -16.188 -21.983 -39.228 1.00 34.08  ? 383  LYS A C   1 
ATOM   784  O  O   . LYS A 1 120 ? -17.268 -22.270 -39.808 1.00 31.20  ? 383  LYS A O   1 
ATOM   785  C  CB  . LYS A 1 120 ? -15.205 -19.739 -39.617 1.00 44.70  ? 383  LYS A CB  1 
ATOM   786  C  CG  . LYS A 1 120 ? -15.291 -18.249 -39.336 1.00 54.68  ? 383  LYS A CG  1 
ATOM   787  C  CD  . LYS A 1 120 ? -14.709 -17.350 -40.397 1.00 61.41  ? 383  LYS A CD  1 
ATOM   788  C  CE  . LYS A 1 120 ? -14.614 -15.922 -39.898 1.00 63.43  ? 383  LYS A CE  1 
ATOM   789  N  NZ  . LYS A 1 120 ? -13.250 -15.386 -40.119 1.00 71.10  ? 383  LYS A NZ  1 
ATOM   790  N  N   . GLU A 1 121 ? -15.182 -22.853 -39.132 1.00 32.01  ? 384  GLU A N   1 
ATOM   791  C  CA  . GLU A 1 121 ? -15.349 -24.196 -39.706 1.00 31.27  ? 384  GLU A CA  1 
ATOM   792  C  C   . GLU A 1 121 ? -16.469 -24.916 -38.981 1.00 32.28  ? 384  GLU A C   1 
ATOM   793  O  O   . GLU A 1 121 ? -17.145 -25.687 -39.660 1.00 33.09  ? 384  GLU A O   1 
ATOM   794  C  CB  . GLU A 1 121 ? -14.153 -25.141 -39.538 1.00 36.57  ? 384  GLU A CB  1 
ATOM   795  C  CG  . GLU A 1 121 ? -13.005 -24.762 -40.377 1.00 41.22  ? 384  GLU A CG  1 
ATOM   796  C  CD  . GLU A 1 121 ? -13.264 -24.789 -41.867 1.00 42.53  ? 384  GLU A CD  1 
ATOM   797  O  OE1 . GLU A 1 121 ? -13.701 -25.845 -42.401 1.00 37.12  ? 384  GLU A OE1 1 
ATOM   798  O  OE2 . GLU A 1 121 ? -12.960 -23.751 -42.472 1.00 43.31  ? 384  GLU A OE2 1 
ATOM   799  N  N   . LEU A 1 122 ? -16.552 -24.787 -37.641 1.00 30.14  ? 385  LEU A N   1 
ATOM   800  C  CA  . LEU A 1 122 ? -17.501 -25.617 -36.850 1.00 27.70  ? 385  LEU A CA  1 
ATOM   801  C  C   . LEU A 1 122 ? -18.930 -25.123 -37.168 1.00 29.94  ? 385  LEU A C   1 
ATOM   802  O  O   . LEU A 1 122 ? -19.892 -25.916 -37.050 1.00 26.31  ? 385  LEU A O   1 
ATOM   803  C  CB  . LEU A 1 122 ? -17.214 -25.472 -35.358 1.00 28.65  ? 385  LEU A CB  1 
ATOM   804  C  CG  . LEU A 1 122 ? -15.932 -26.179 -34.892 1.00 29.15  ? 385  LEU A CG  1 
ATOM   805  C  CD1 . LEU A 1 122 ? -15.655 -25.908 -33.431 1.00 28.94  ? 385  LEU A CD1 1 
ATOM   806  C  CD2 . LEU A 1 122 ? -16.079 -27.671 -35.171 1.00 31.71  ? 385  LEU A CD2 1 
ATOM   807  N  N   . GLY A 1 123 ? -19.025 -23.847 -37.509 1.00 31.22  ? 386  GLY A N   1 
ATOM   808  C  CA  . GLY A 1 123 ? -20.292 -23.147 -37.787 1.00 35.41  ? 386  GLY A CA  1 
ATOM   809  C  C   . GLY A 1 123 ? -20.720 -23.244 -39.236 1.00 38.46  ? 386  GLY A C   1 
ATOM   810  O  O   . GLY A 1 123 ? -21.880 -22.906 -39.492 1.00 40.20  ? 386  GLY A O   1 
ATOM   811  N  N   . LYS A 1 124 ? -19.881 -23.719 -40.156 1.00 34.94  ? 387  LYS A N   1 
ATOM   812  C  CA  . LYS A 1 124 ? -20.269 -23.851 -41.589 1.00 41.53  ? 387  LYS A CA  1 
ATOM   813  C  C   . LYS A 1 124 ? -21.581 -24.633 -41.766 1.00 44.64  ? 387  LYS A C   1 
ATOM   814  O  O   . LYS A 1 124 ? -22.373 -24.223 -42.615 1.00 42.28  ? 387  LYS A O   1 
ATOM   815  C  CB  . LYS A 1 124 ? -19.185 -24.504 -42.445 1.00 42.13  ? 387  LYS A CB  1 
ATOM   816  C  CG  . LYS A 1 124 ? -18.152 -23.521 -42.983 1.00 48.29  ? 387  LYS A CG  1 
ATOM   817  C  CD  . LYS A 1 124 ? -17.153 -24.143 -43.947 1.00 51.84  ? 387  LYS A CD  1 
ATOM   818  C  CE  . LYS A 1 124 ? -15.842 -23.391 -44.037 1.00 51.12  ? 387  LYS A CE  1 
ATOM   819  N  NZ  . LYS A 1 124 ? -14.825 -24.237 -44.706 1.00 56.87  ? 387  LYS A NZ  1 
ATOM   820  N  N   . LYS A 1 125 ? -21.809 -25.731 -41.047 1.00 40.66  ? 388  LYS A N   1 
ATOM   821  C  CA  . LYS A 1 125 ? -23.019 -26.581 -41.234 1.00 39.25  ? 388  LYS A CA  1 
ATOM   822  C  C   . LYS A 1 125 ? -23.898 -26.614 -39.976 1.00 36.21  ? 388  LYS A C   1 
ATOM   823  O  O   . LYS A 1 125 ? -24.685 -27.536 -39.847 1.00 39.34  ? 388  LYS A O   1 
ATOM   824  C  CB  . LYS A 1 125 ? -22.567 -27.982 -41.621 1.00 42.80  ? 388  LYS A CB  1 
ATOM   825  C  CG  . LYS A 1 125 ? -21.897 -28.073 -42.986 1.00 51.36  ? 388  LYS A CG  1 
ATOM   826  C  CD  . LYS A 1 125 ? -21.451 -29.487 -43.317 1.00 57.32  ? 388  LYS A CD  1 
ATOM   827  C  CE  . LYS A 1 125 ? -20.222 -29.918 -42.540 1.00 65.34  ? 388  LYS A CE  1 
ATOM   828  N  NZ  . LYS A 1 125 ? -20.238 -31.368 -42.231 1.00 65.87  ? 388  LYS A NZ  1 
ATOM   829  N  N   . LYS A 1 126 ? -23.739 -25.679 -39.050 1.00 32.79  ? 389  LYS A N   1 
ATOM   830  C  CA  . LYS A 1 126 ? -24.528 -25.654 -37.806 1.00 37.29  ? 389  LYS A CA  1 
ATOM   831  C  C   . LYS A 1 126 ? -25.023 -24.231 -37.614 1.00 40.66  ? 389  LYS A C   1 
ATOM   832  O  O   . LYS A 1 126 ? -24.294 -23.344 -37.997 1.00 42.21  ? 389  LYS A O   1 
ATOM   833  C  CB  . LYS A 1 126 ? -23.702 -26.038 -36.575 1.00 34.89  ? 389  LYS A CB  1 
ATOM   834  C  CG  . LYS A 1 126 ? -23.105 -27.429 -36.633 1.00 34.44  ? 389  LYS A CG  1 
ATOM   835  C  CD  . LYS A 1 126 ? -24.097 -28.492 -36.246 1.00 34.89  ? 389  LYS A CD  1 
ATOM   836  C  CE  . LYS A 1 126 ? -23.424 -29.840 -36.210 1.00 34.66  ? 389  LYS A CE  1 
ATOM   837  N  NZ  . LYS A 1 126 ? -24.410 -30.919 -36.338 1.00 35.06  ? 389  LYS A NZ  1 
ATOM   838  N  N   . THR A 1 127 ? -26.152 -24.062 -36.914 1.00 35.67  ? 390  THR A N   1 
ATOM   839  C  CA  . THR A 1 127 ? -26.709 -22.732 -36.561 1.00 36.78  ? 390  THR A CA  1 
ATOM   840  C  C   . THR A 1 127 ? -26.775 -22.591 -35.055 1.00 29.24  ? 390  THR A C   1 
ATOM   841  O  O   . THR A 1 127 ? -27.538 -23.304 -34.439 1.00 35.21  ? 390  THR A O   1 
ATOM   842  C  CB  . THR A 1 127 ? -28.134 -22.584 -37.128 1.00 43.20  ? 390  THR A CB  1 
ATOM   843  O  OG1 . THR A 1 127 ? -28.030 -22.795 -38.540 1.00 40.42  ? 390  THR A OG1 1 
ATOM   844  C  CG2 . THR A 1 127 ? -28.746 -21.249 -36.765 1.00 40.27  ? 390  THR A CG2 1 
ATOM   845  N  N   . PRO A 1 128 ? -26.040 -21.663 -34.411 1.00 28.91  ? 391  PRO A N   1 
ATOM   846  C  CA  . PRO A 1 128 ? -26.178 -21.467 -32.974 1.00 31.08  ? 391  PRO A CA  1 
ATOM   847  C  C   . PRO A 1 128 ? -27.646 -21.110 -32.661 1.00 37.20  ? 391  PRO A C   1 
ATOM   848  O  O   . PRO A 1 128 ? -28.309 -20.487 -33.484 1.00 39.08  ? 391  PRO A O   1 
ATOM   849  C  CB  . PRO A 1 128 ? -25.253 -20.291 -32.664 1.00 30.18  ? 391  PRO A CB  1 
ATOM   850  C  CG  . PRO A 1 128 ? -24.317 -20.227 -33.837 1.00 32.75  ? 391  PRO A CG  1 
ATOM   851  C  CD  . PRO A 1 128 ? -25.082 -20.742 -35.021 1.00 30.86  ? 391  PRO A CD  1 
ATOM   852  N  N   . ARG A 1 129 ? -28.135 -21.503 -31.499 1.00 36.60  ? 392  ARG A N   1 
ATOM   853  C  CA  . ARG A 1 129 ? -29.560 -21.287 -31.135 1.00 36.42  ? 392  ARG A CA  1 
ATOM   854  C  C   . ARG A 1 129 ? -29.679 -21.436 -29.626 1.00 47.63  ? 392  ARG A C   1 
ATOM   855  O  O   . ARG A 1 129 ? -28.804 -22.103 -29.025 1.00 37.43  ? 392  ARG A O   1 
ATOM   856  C  CB  . ARG A 1 129 ? -30.480 -22.212 -31.934 1.00 36.31  ? 392  ARG A CB  1 
ATOM   857  C  CG  . ARG A 1 129 ? -30.200 -23.706 -31.849 1.00 36.88  ? 392  ARG A CG  1 
ATOM   858  C  CD  . ARG A 1 129 ? -31.125 -24.418 -30.948 1.00 36.66  ? 392  ARG A CD  1 
ATOM   859  N  NE  . ARG A 1 129 ? -30.801 -25.815 -30.670 1.00 34.85  ? 392  ARG A NE  1 
ATOM   860  C  CZ  . ARG A 1 129 ? -31.366 -26.488 -29.686 1.00 35.76  ? 392  ARG A CZ  1 
ATOM   861  N  NH1 . ARG A 1 129 ? -32.324 -25.919 -28.976 1.00 36.41  ? 392  ARG A NH1 1 
ATOM   862  N  NH2 . ARG A 1 129 ? -31.083 -27.754 -29.483 1.00 35.15  ? 392  ARG A NH2 1 
ATOM   863  N  N   . MET A 1 130 ? -30.687 -20.781 -29.038 1.00 44.79  ? 393  MET A N   1 
ATOM   864  C  CA  . MET A 1 130 ? -30.982 -20.903 -27.600 1.00 45.66  ? 393  MET A CA  1 
ATOM   865  C  C   . MET A 1 130 ? -31.620 -22.262 -27.342 1.00 40.34  ? 393  MET A C   1 
ATOM   866  O  O   . MET A 1 130 ? -32.367 -22.777 -28.178 1.00 43.08  ? 393  MET A O   1 
ATOM   867  C  CB  . MET A 1 130 ? -31.903 -19.789 -27.107 1.00 54.72  ? 393  MET A CB  1 
ATOM   868  C  CG  . MET A 1 130 ? -31.259 -18.421 -27.170 1.00 62.89  ? 393  MET A CG  1 
ATOM   869  S  SD  . MET A 1 130 ? -32.213 -17.119 -26.331 1.00 71.44  ? 393  MET A SD  1 
ATOM   870  C  CE  . MET A 1 130 ? -33.885 -17.592 -26.774 1.00 68.97  ? 393  MET A CE  1 
ATOM   871  N  N   . CYS A 1 131 ? -31.267 -22.861 -26.220 1.00 36.53  ? 394  CYS A N   1 
ATOM   872  C  CA  . CYS A 1 131 ? -31.935 -24.058 -25.694 1.00 38.29  ? 394  CYS A CA  1 
ATOM   873  C  C   . CYS A 1 131 ? -33.095 -23.590 -24.798 1.00 41.43  ? 394  CYS A C   1 
ATOM   874  O  O   . CYS A 1 131 ? -33.060 -22.419 -24.319 1.00 46.22  ? 394  CYS A O   1 
ATOM   875  C  CB  . CYS A 1 131 ? -30.922 -24.948 -24.999 1.00 40.73  ? 394  CYS A CB  1 
ATOM   876  S  SG  . CYS A 1 131 ? -29.811 -25.770 -26.169 1.00 41.45  ? 394  CYS A SG  1 
ATOM   877  N  N   . THR A 1 132 ? -34.135 -24.410 -24.666 1.00 44.43  ? 395  THR A N   1 
ATOM   878  C  CA  . THR A 1 132 ? -35.453 -23.959 -24.140 1.00 53.47  ? 395  THR A CA  1 
ATOM   879  C  C   . THR A 1 132 ? -35.734 -24.536 -22.751 1.00 52.48  ? 395  THR A C   1 
ATOM   880  O  O   . THR A 1 132 ? -35.221 -25.635 -22.422 1.00 45.69  ? 395  THR A O   1 
ATOM   881  C  CB  . THR A 1 132 ? -36.587 -24.420 -25.063 1.00 46.99  ? 395  THR A CB  1 
ATOM   882  O  OG1 . THR A 1 132 ? -36.548 -25.842 -25.054 1.00 52.28  ? 395  THR A OG1 1 
ATOM   883  C  CG2 . THR A 1 132 ? -36.444 -23.927 -26.484 1.00 56.97  ? 395  THR A CG2 1 
ATOM   884  N  N   . ARG A 1 133 ? -36.549 -23.827 -21.964 0.50 55.98  ? 396  ARG A N   1 
ATOM   885  C  CA  . ARG A 1 133 ? -37.088 -24.308 -20.661 0.50 58.62  ? 396  ARG A CA  1 
ATOM   886  C  C   . ARG A 1 133 ? -37.696 -25.701 -20.859 0.50 57.76  ? 396  ARG A C   1 
ATOM   887  O  O   . ARG A 1 133 ? -37.481 -26.571 -19.991 0.50 59.42  ? 396  ARG A O   1 
ATOM   888  C  CB  . ARG A 1 133 ? -38.113 -23.313 -20.111 0.50 60.72  ? 396  ARG A CB  1 
ATOM   889  C  CG  . ARG A 1 133 ? -37.537 -21.924 -19.886 0.50 65.65  ? 396  ARG A CG  1 
ATOM   890  C  CD  . ARG A 1 133 ? -38.466 -20.973 -19.159 0.50 68.72  ? 396  ARG A CD  1 
ATOM   891  N  NE  . ARG A 1 133 ? -37.776 -19.743 -18.796 0.50 70.84  ? 396  ARG A NE  1 
ATOM   892  C  CZ  . ARG A 1 133 ? -38.315 -18.760 -18.085 0.50 75.41  ? 396  ARG A CZ  1 
ATOM   893  N  NH1 . ARG A 1 133 ? -39.564 -18.859 -17.663 0.50 76.08  ? 396  ARG A NH1 1 
ATOM   894  N  NH2 . ARG A 1 133 ? -37.605 -17.680 -17.805 0.50 74.61  ? 396  ARG A NH2 1 
ATOM   895  N  N   . GLU A 1 134 ? -38.328 -25.918 -22.003 1.00 58.98  ? 397  GLU A N   1 
ATOM   896  C  CA  . GLU A 1 134 ? -38.926 -27.237 -22.287 1.00 59.90  ? 397  GLU A CA  1 
ATOM   897  C  C   . GLU A 1 134 ? -37.805 -28.273 -22.349 1.00 55.06  ? 397  GLU A C   1 
ATOM   898  O  O   . GLU A 1 134 ? -37.916 -29.288 -21.665 1.00 58.63  ? 397  GLU A O   1 
ATOM   899  C  CB  . GLU A 1 134 ? -39.762 -27.141 -23.562 1.00 69.76  ? 397  GLU A CB  1 
ATOM   900  C  CG  . GLU A 1 134 ? -40.987 -26.254 -23.425 1.00 76.02  ? 397  GLU A CG  1 
ATOM   901  C  CD  . GLU A 1 134 ? -40.764 -24.753 -23.504 1.00 78.83  ? 397  GLU A CD  1 
ATOM   902  O  OE1 . GLU A 1 134 ? -39.626 -24.331 -23.766 1.00 61.28  ? 397  GLU A OE1 1 
ATOM   903  O  OE2 . GLU A 1 134 ? -41.741 -24.007 -23.305 1.00 88.05  ? 397  GLU A OE2 1 
ATOM   904  N  N   . GLU A 1 135 ? -36.756 -28.003 -23.127 1.00 57.94  ? 398  GLU A N   1 
ATOM   905  C  CA  . GLU A 1 135 ? -35.617 -28.951 -23.250 1.00 57.60  ? 398  GLU A CA  1 
ATOM   906  C  C   . GLU A 1 135 ? -34.994 -29.185 -21.876 1.00 58.04  ? 398  GLU A C   1 
ATOM   907  O  O   . GLU A 1 135 ? -34.680 -30.340 -21.565 1.00 54.73  ? 398  GLU A O   1 
ATOM   908  C  CB  . GLU A 1 135 ? -34.518 -28.393 -24.154 1.00 56.34  ? 398  GLU A CB  1 
ATOM   909  C  CG  . GLU A 1 135 ? -34.848 -28.403 -25.630 1.00 58.83  ? 398  GLU A CG  1 
ATOM   910  C  CD  . GLU A 1 135 ? -33.767 -27.763 -26.482 1.00 47.54  ? 398  GLU A CD  1 
ATOM   911  O  OE1 . GLU A 1 135 ? -33.612 -26.537 -26.407 1.00 49.71  ? 398  GLU A OE1 1 
ATOM   912  O  OE2 . GLU A 1 135 ? -33.075 -28.499 -27.202 1.00 56.10  ? 398  GLU A OE2 1 
ATOM   913  N  N   . PHE A 1 136 ? -34.795 -28.111 -21.116 1.00 55.13  ? 399  PHE A N   1 
ATOM   914  C  CA  . PHE A 1 136 ? -34.152 -28.221 -19.785 1.00 56.23  ? 399  PHE A CA  1 
ATOM   915  C  C   . PHE A 1 136 ? -35.045 -29.051 -18.853 1.00 62.31  ? 399  PHE A C   1 
ATOM   916  O  O   . PHE A 1 136 ? -34.527 -29.943 -18.162 1.00 51.30  ? 399  PHE A O   1 
ATOM   917  C  CB  . PHE A 1 136 ? -33.869 -26.819 -19.250 1.00 57.01  ? 399  PHE A CB  1 
ATOM   918  C  CG  . PHE A 1 136 ? -33.086 -26.781 -17.963 1.00 60.04  ? 399  PHE A CG  1 
ATOM   919  C  CD1 . PHE A 1 136 ? -31.719 -26.992 -17.959 1.00 54.08  ? 399  PHE A CD1 1 
ATOM   920  C  CD2 . PHE A 1 136 ? -33.716 -26.529 -16.756 1.00 60.43  ? 399  PHE A CD2 1 
ATOM   921  C  CE1 . PHE A 1 136 ? -30.998 -26.954 -16.778 1.00 53.52  ? 399  PHE A CE1 1 
ATOM   922  C  CE2 . PHE A 1 136 ? -32.995 -26.492 -15.575 1.00 60.54  ? 399  PHE A CE2 1 
ATOM   923  C  CZ  . PHE A 1 136 ? -31.637 -26.705 -15.588 1.00 61.13  ? 399  PHE A CZ  1 
ATOM   924  N  N   . THR A 1 137 ? -36.349 -28.770 -18.864 1.00 57.89  ? 400  THR A N   1 
ATOM   925  C  CA  . THR A 1 137 ? -37.303 -29.526 -18.014 1.00 65.29  ? 400  THR A CA  1 
ATOM   926  C  C   . THR A 1 137 ? -37.228 -31.008 -18.376 1.00 66.98  ? 400  THR A C   1 
ATOM   927  O  O   . THR A 1 137 ? -37.158 -31.840 -17.470 1.00 56.26  ? 400  THR A O   1 
ATOM   928  C  CB  . THR A 1 137 ? -38.728 -29.007 -18.222 1.00 59.47  ? 400  THR A CB  1 
ATOM   929  O  OG1 . THR A 1 137 ? -38.790 -27.655 -17.770 1.00 63.13  ? 400  THR A OG1 1 
ATOM   930  C  CG2 . THR A 1 137 ? -39.768 -29.855 -17.524 1.00 62.93  ? 400  THR A CG2 1 
ATOM   931  N  N   . ARG A 1 138 ? -37.219 -31.310 -19.669 1.00 70.79  ? 401  ARG A N   1 
ATOM   932  C  CA  . ARG A 1 138 ? -37.244 -32.725 -20.103 1.00 74.56  ? 401  ARG A CA  1 
ATOM   933  C  C   . ARG A 1 138 ? -35.976 -33.423 -19.619 1.00 77.10  ? 401  ARG A C   1 
ATOM   934  O  O   . ARG A 1 138 ? -36.043 -34.615 -19.296 1.00 77.53  ? 401  ARG A O   1 
ATOM   935  C  CB  . ARG A 1 138 ? -37.373 -32.777 -21.625 1.00 85.97  ? 401  ARG A CB  1 
ATOM   936  C  CG  . ARG A 1 138 ? -37.698 -34.155 -22.181 1.00 91.89  ? 401  ARG A CG  1 
ATOM   937  C  CD  . ARG A 1 138 ? -38.430 -34.045 -23.504 1.00 88.56  ? 401  ARG A CD  1 
ATOM   938  N  NE  . ARG A 1 138 ? -37.659 -33.283 -24.471 1.00 94.90  ? 401  ARG A NE  1 
ATOM   939  C  CZ  . ARG A 1 138 ? -36.878 -33.815 -25.401 1.00 94.20  ? 401  ARG A CZ  1 
ATOM   940  N  NH1 . ARG A 1 138 ? -36.772 -35.129 -25.505 1.00 95.75  ? 401  ARG A NH1 1 
ATOM   941  N  NH2 . ARG A 1 138 ? -36.212 -33.031 -26.230 1.00 89.61  ? 401  ARG A NH2 1 
ATOM   942  N  N   . LYS A 1 139 ? -34.859 -32.701 -19.602 1.00 75.76  ? 402  LYS A N   1 
ATOM   943  C  CA  . LYS A 1 139 ? -33.577 -33.310 -19.176 1.00 79.32  ? 402  LYS A CA  1 
ATOM   944  C  C   . LYS A 1 139 ? -33.683 -33.680 -17.697 1.00 89.21  ? 402  LYS A C   1 
ATOM   945  O  O   . LYS A 1 139 ? -33.358 -34.830 -17.351 1.00 88.16  ? 402  LYS A O   1 
ATOM   946  C  CB  . LYS A 1 139 ? -32.419 -32.335 -19.394 1.00 75.10  ? 402  LYS A CB  1 
ATOM   947  C  CG  . LYS A 1 139 ? -32.184 -31.917 -20.839 1.00 80.61  ? 402  LYS A CG  1 
ATOM   948  C  CD  . LYS A 1 139 ? -30.952 -31.060 -21.030 1.00 79.98  ? 402  LYS A CD  1 
ATOM   949  C  CE  . LYS A 1 139 ? -29.660 -31.846 -20.970 1.00 81.61  ? 402  LYS A CE  1 
ATOM   950  N  NZ  . LYS A 1 139 ? -29.548 -32.812 -22.087 1.00 76.01  ? 402  LYS A NZ  1 
ATOM   951  N  N   . VAL A 1 140 ? -34.140 -32.740 -16.868 0.50 89.99  ? 403  VAL A N   1 
ATOM   952  C  CA  . VAL A 1 140 ? -34.204 -32.987 -15.400 0.50 93.30  ? 403  VAL A CA  1 
ATOM   953  C  C   . VAL A 1 140 ? -35.200 -34.117 -15.126 0.50 95.57  ? 403  VAL A C   1 
ATOM   954  O  O   . VAL A 1 140 ? -34.926 -34.928 -14.223 0.50 98.37  ? 403  VAL A O   1 
ATOM   955  C  CB  . VAL A 1 140 ? -34.579 -31.704 -14.636 0.50 93.51  ? 403  VAL A CB  1 
ATOM   956  C  CG1 . VAL A 1 140 ? -33.742 -30.516 -15.084 0.50 92.48  ? 403  VAL A CG1 1 
ATOM   957  C  CG2 . VAL A 1 140 ? -36.061 -31.387 -14.750 0.50 94.17  ? 403  VAL A CG2 1 
ATOM   958  N  N   . ARG A 1 141 ? -36.299 -34.174 -15.882 0.50 94.84  ? 404  ARG A N   1 
ATOM   959  C  CA  . ARG A 1 141 ? -37.354 -35.191 -15.622 0.50 93.39  ? 404  ARG A CA  1 
ATOM   960  C  C   . ARG A 1 141 ? -36.883 -36.547 -16.144 0.50 94.81  ? 404  ARG A C   1 
ATOM   961  O  O   . ARG A 1 141 ? -37.698 -37.484 -16.163 0.50 98.01  ? 404  ARG A O   1 
ATOM   962  C  CB  . ARG A 1 141 ? -38.684 -34.762 -16.245 0.50 91.39  ? 404  ARG A CB  1 
ATOM   963  C  CG  . ARG A 1 141 ? -39.353 -33.610 -15.509 0.50 92.49  ? 404  ARG A CG  1 
ATOM   964  C  CD  . ARG A 1 141 ? -40.858 -33.780 -15.439 0.50 94.05  ? 404  ARG A CD  1 
ATOM   965  N  NE  . ARG A 1 141 ? -41.555 -33.179 -16.565 0.50 94.70  ? 404  ARG A NE  1 
ATOM   966  C  CZ  . ARG A 1 141 ? -42.108 -31.973 -16.541 0.50 94.73  ? 404  ARG A CZ  1 
ATOM   967  N  NH1 . ARG A 1 141 ? -42.045 -31.240 -15.444 0.50 94.34  ? 404  ARG A NH1 1 
ATOM   968  N  NH2 . ARG A 1 141 ? -42.724 -31.506 -17.612 0.50 94.21  ? 404  ARG A NH2 1 
ATOM   969  N  N   . SER A 1 142 ? -35.618 -36.637 -16.552 0.50 96.76  ? 405  SER A N   1 
ATOM   970  C  CA  . SER A 1 142 ? -35.050 -37.930 -17.005 0.50 99.06  ? 405  SER A CA  1 
ATOM   971  C  C   . SER A 1 142 ? -33.625 -38.060 -16.462 0.50 97.70  ? 405  SER A C   1 
ATOM   972  O  O   . SER A 1 142 ? -32.830 -38.806 -17.061 0.50 96.94  ? 405  SER A O   1 
ATOM   973  C  CB  . SER A 1 142 ? -35.086 -38.034 -18.506 0.50 101.89 ? 405  SER A CB  1 
ATOM   974  O  OG  . SER A 1 142 ? -34.464 -36.905 -19.103 0.50 102.61 ? 405  SER A OG  1 
ATOM   975  N  N   . ASN A 1 143 ? -33.322 -37.350 -15.373 0.50 95.90  ? 406  ASN A N   1 
ATOM   976  C  CA  . ASN A 1 143 ? -31.957 -37.383 -14.786 0.50 95.08  ? 406  ASN A CA  1 
ATOM   977  C  C   . ASN A 1 143 ? -30.926 -37.425 -15.916 0.50 92.24  ? 406  ASN A C   1 
ATOM   978  O  O   . ASN A 1 143 ? -29.946 -36.664 -15.819 0.50 90.95  ? 406  ASN A O   1 
ATOM   979  C  CB  . ASN A 1 143 ? -31.772 -38.565 -13.830 0.50 95.82  ? 406  ASN A CB  1 
ATOM   980  C  CG  . ASN A 1 143 ? -32.857 -38.658 -12.779 0.50 94.89  ? 406  ASN A CG  1 
ATOM   981  O  OD1 . ASN A 1 143 ? -33.865 -37.960 -12.853 0.50 97.98  ? 406  ASN A OD1 1 
ATOM   982  N  ND2 . ASN A 1 143 ? -32.661 -39.525 -11.799 0.50 92.59  ? 406  ASN A ND2 1 
ATOM   983  N  N   . LYS A 1 155 ? -35.491 -24.200 -0.756  0.50 95.76  ? 418  LYS A N   1 
ATOM   984  C  CA  . LYS A 1 155 ? -36.975 -24.256 -0.805  0.50 95.09  ? 418  LYS A CA  1 
ATOM   985  C  C   . LYS A 1 155 ? -37.419 -25.554 -1.483  0.50 97.31  ? 418  LYS A C   1 
ATOM   986  O  O   . LYS A 1 155 ? -38.025 -26.398 -0.799  0.50 100.15 ? 418  LYS A O   1 
ATOM   987  C  CB  . LYS A 1 155 ? -37.525 -23.044 -1.561  0.50 92.55  ? 418  LYS A CB  1 
ATOM   988  C  CG  . LYS A 1 155 ? -39.028 -23.058 -1.803  0.50 90.56  ? 418  LYS A CG  1 
ATOM   989  C  CD  . LYS A 1 155 ? -39.523 -21.840 -2.550  0.50 86.66  ? 418  LYS A CD  1 
ATOM   990  C  CE  . LYS A 1 155 ? -41.025 -21.830 -2.732  0.50 84.38  ? 418  LYS A CE  1 
ATOM   991  N  NZ  . LYS A 1 155 ? -41.487 -20.599 -3.414  0.50 83.91  ? 418  LYS A NZ  1 
ATOM   992  N  N   . TRP A 1 156 ? -37.133 -25.698 -2.779  1.00 97.75  ? 419  TRP A N   1 
ATOM   993  C  CA  . TRP A 1 156 ? -37.528 -26.916 -3.535  1.00 96.11  ? 419  TRP A CA  1 
ATOM   994  C  C   . TRP A 1 156 ? -36.595 -28.062 -3.154  1.00 95.39  ? 419  TRP A C   1 
ATOM   995  O  O   . TRP A 1 156 ? -35.380 -27.827 -3.078  1.00 99.93  ? 419  TRP A O   1 
ATOM   996  C  CB  . TRP A 1 156 ? -37.507 -26.650 -5.051  1.00 96.67  ? 419  TRP A CB  1 
ATOM   997  C  CG  . TRP A 1 156 ? -38.091 -25.330 -5.448  1.00 88.52  ? 419  TRP A CG  1 
ATOM   998  C  CD1 . TRP A 1 156 ? -39.405 -25.045 -5.676  1.00 85.12  ? 419  TRP A CD1 1 
ATOM   999  C  CD2 . TRP A 1 156 ? -37.372 -24.105 -5.666  1.00 84.24  ? 419  TRP A CD2 1 
ATOM   1000 N  NE1 . TRP A 1 156 ? -39.551 -23.729 -6.018  1.00 82.43  ? 419  TRP A NE1 1 
ATOM   1001 C  CE2 . TRP A 1 156 ? -38.322 -23.127 -6.022  1.00 81.96  ? 419  TRP A CE2 1 
ATOM   1002 C  CE3 . TRP A 1 156 ? -36.024 -23.741 -5.599  1.00 82.92  ? 419  TRP A CE3 1 
ATOM   1003 C  CZ2 . TRP A 1 156 ? -37.966 -21.811 -6.304  1.00 85.18  ? 419  TRP A CZ2 1 
ATOM   1004 C  CZ3 . TRP A 1 156 ? -35.672 -22.441 -5.880  1.00 81.21  ? 419  TRP A CZ3 1 
ATOM   1005 C  CH2 . TRP A 1 156 ? -36.631 -21.491 -6.227  1.00 85.83  ? 419  TRP A CH2 1 
ATOM   1006 N  N   . LYS A 1 157 ? -37.148 -29.254 -2.934  1.00 102.32 ? 420  LYS A N   1 
ATOM   1007 C  CA  . LYS A 1 157 ? -36.329 -30.416 -2.504  1.00 105.09 ? 420  LYS A CA  1 
ATOM   1008 C  C   . LYS A 1 157 ? -35.402 -30.859 -3.627  1.00 108.04 ? 420  LYS A C   1 
ATOM   1009 O  O   . LYS A 1 157 ? -34.189 -30.980 -3.373  1.00 104.41 ? 420  LYS A O   1 
ATOM   1010 C  CB  . LYS A 1 157 ? -37.229 -31.610 -2.187  1.00 110.27 ? 420  LYS A CB  1 
ATOM   1011 C  CG  . LYS A 1 157 ? -36.505 -32.944 -2.070  1.00 111.27 ? 420  LYS A CG  1 
ATOM   1012 C  CD  . LYS A 1 157 ? -37.375 -34.133 -2.410  1.00 112.03 ? 420  LYS A CD  1 
ATOM   1013 C  CE  . LYS A 1 157 ? -38.563 -34.291 -1.486  1.00 107.13 ? 420  LYS A CE  1 
ATOM   1014 N  NZ  . LYS A 1 157 ? -39.339 -35.513 -1.803  1.00 110.32 ? 420  LYS A NZ  1 
ATOM   1015 N  N   . SER A 1 158 ? -35.953 -31.070 -4.823  1.00 106.90 ? 421  SER A N   1 
ATOM   1016 C  CA  . SER A 1 158 ? -35.138 -31.615 -5.936  1.00 96.22  ? 421  SER A CA  1 
ATOM   1017 C  C   . SER A 1 158 ? -35.260 -30.722 -7.172  1.00 96.44  ? 421  SER A C   1 
ATOM   1018 O  O   . SER A 1 158 ? -36.044 -29.758 -7.134  1.00 83.58  ? 421  SER A O   1 
ATOM   1019 C  CB  . SER A 1 158 ? -35.565 -33.026 -6.241  1.00 89.03  ? 421  SER A CB  1 
ATOM   1020 O  OG  . SER A 1 158 ? -36.954 -33.083 -6.521  1.00 86.01  ? 421  SER A OG  1 
ATOM   1021 N  N   . ALA A 1 159 ? -34.500 -31.041 -8.222  1.00 95.27  ? 422  ALA A N   1 
ATOM   1022 C  CA  . ALA A 1 159 ? -34.565 -30.267 -9.484  1.00 93.28  ? 422  ALA A CA  1 
ATOM   1023 C  C   . ALA A 1 159 ? -35.935 -30.449 -10.131 1.00 87.56  ? 422  ALA A C   1 
ATOM   1024 O  O   . ALA A 1 159 ? -36.513 -29.458 -10.589 1.00 74.15  ? 422  ALA A O   1 
ATOM   1025 C  CB  . ALA A 1 159 ? -33.474 -30.748 -10.389 1.00 98.53  ? 422  ALA A CB  1 
ATOM   1026 N  N   . ARG A 1 160 ? -36.439 -31.682 -10.127 0.50 88.40  ? 423  ARG A N   1 
ATOM   1027 C  CA  . ARG A 1 160 ? -37.765 -31.964 -10.727 0.50 90.09  ? 423  ARG A CA  1 
ATOM   1028 C  C   . ARG A 1 160 ? -38.802 -31.041 -10.078 0.50 91.68  ? 423  ARG A C   1 
ATOM   1029 O  O   . ARG A 1 160 ? -39.698 -30.567 -10.795 0.50 91.55  ? 423  ARG A O   1 
ATOM   1030 C  CB  . ARG A 1 160 ? -38.096 -33.444 -10.532 0.50 91.10  ? 423  ARG A CB  1 
ATOM   1031 C  CG  . ARG A 1 160 ? -39.315 -33.921 -11.305 0.50 94.54  ? 423  ARG A CG  1 
ATOM   1032 C  CD  . ARG A 1 160 ? -39.601 -35.380 -11.008 0.50 96.01  ? 423  ARG A CD  1 
ATOM   1033 N  NE  . ARG A 1 160 ? -38.426 -36.220 -11.191 0.50 95.91  ? 423  ARG A NE  1 
ATOM   1034 C  CZ  . ARG A 1 160 ? -38.147 -36.891 -12.302 0.50 97.04  ? 423  ARG A CZ  1 
ATOM   1035 N  NH1 . ARG A 1 160 ? -37.053 -37.629 -12.372 0.50 96.24  ? 423  ARG A NH1 1 
ATOM   1036 N  NH2 . ARG A 1 160 ? -38.966 -36.826 -13.336 0.50 97.40  ? 423  ARG A NH2 1 
ATOM   1037 N  N   . GLU A 1 161 ? -38.671 -30.789 -8.773  0.50 92.23  ? 424  GLU A N   1 
ATOM   1038 C  CA  . GLU A 1 161 ? -39.652 -29.936 -8.051  0.50 91.84  ? 424  GLU A CA  1 
ATOM   1039 C  C   . GLU A 1 161 ? -39.530 -28.488 -8.529  0.50 87.66  ? 424  GLU A C   1 
ATOM   1040 O  O   . GLU A 1 161 ? -40.572 -27.878 -8.827  0.50 85.69  ? 424  GLU A O   1 
ATOM   1041 C  CB  . GLU A 1 161 ? -39.416 -30.009 -6.542  0.50 95.89  ? 424  GLU A CB  1 
ATOM   1042 C  CG  . GLU A 1 161 ? -39.681 -31.381 -5.952  0.50 99.52  ? 424  GLU A CG  1 
ATOM   1043 C  CD  . GLU A 1 161 ? -39.770 -31.401 -4.435  0.50 102.34 ? 424  GLU A CD  1 
ATOM   1044 O  OE1 . GLU A 1 161 ? -39.471 -30.363 -3.814  0.50 102.64 ? 424  GLU A OE1 1 
ATOM   1045 O  OE2 . GLU A 1 161 ? -40.148 -32.452 -3.880  0.50 101.89 ? 424  GLU A OE2 1 
ATOM   1046 N  N   . ALA A 1 162 ? -38.304 -27.965 -8.597  0.50 83.90  ? 425  ALA A N   1 
ATOM   1047 C  CA  . ALA A 1 162 ? -38.102 -26.549 -8.979  0.50 83.45  ? 425  ALA A CA  1 
ATOM   1048 C  C   . ALA A 1 162 ? -38.595 -26.313 -10.407 0.50 82.47  ? 425  ALA A C   1 
ATOM   1049 O  O   . ALA A 1 162 ? -39.225 -25.268 -10.648 0.50 78.19  ? 425  ALA A O   1 
ATOM   1050 C  CB  . ALA A 1 162 ? -36.642 -26.201 -8.841  0.50 82.32  ? 425  ALA A CB  1 
ATOM   1051 N  N   . VAL A 1 163 ? -38.323 -27.254 -11.310 0.50 84.78  ? 426  VAL A N   1 
ATOM   1052 C  CA  . VAL A 1 163 ? -38.686 -27.077 -12.747 0.50 90.12  ? 426  VAL A CA  1 
ATOM   1053 C  C   . VAL A 1 163 ? -40.194 -26.858 -12.862 0.50 92.23  ? 426  VAL A C   1 
ATOM   1054 O  O   . VAL A 1 163 ? -40.625 -26.199 -13.827 0.50 90.38  ? 426  VAL A O   1 
ATOM   1055 C  CB  . VAL A 1 163 ? -38.235 -28.300 -13.567 0.50 90.86  ? 426  VAL A CB  1 
ATOM   1056 C  CG1 . VAL A 1 163 ? -38.859 -28.316 -14.950 0.50 92.12  ? 426  VAL A CG1 1 
ATOM   1057 C  CG2 . VAL A 1 163 ? -36.720 -28.384 -13.658 0.50 91.68  ? 426  VAL A CG2 1 
ATOM   1058 N  N   . GLU A 1 164 ? -40.959 -27.382 -11.907 1.00 96.26  ? 427  GLU A N   1 
ATOM   1059 C  CA  . GLU A 1 164 ? -42.444 -27.288 -11.987 1.00 101.82 ? 427  GLU A CA  1 
ATOM   1060 C  C   . GLU A 1 164 ? -42.939 -26.041 -11.240 1.00 96.33  ? 427  GLU A C   1 
ATOM   1061 O  O   . GLU A 1 164 ? -44.045 -25.562 -11.556 1.00 95.61  ? 427  GLU A O   1 
ATOM   1062 C  CB  . GLU A 1 164 ? -43.042 -28.597 -11.467 1.00 103.20 ? 427  GLU A CB  1 
ATOM   1063 C  CG  . GLU A 1 164 ? -42.533 -29.804 -12.233 1.00 106.95 ? 427  GLU A CG  1 
ATOM   1064 C  CD  . GLU A 1 164 ? -42.525 -31.115 -11.469 1.00 117.35 ? 427  GLU A CD  1 
ATOM   1065 O  OE1 . GLU A 1 164 ? -43.098 -31.158 -10.366 1.00 132.26 ? 427  GLU A OE1 1 
ATOM   1066 O  OE2 . GLU A 1 164 ? -41.934 -32.088 -11.978 1.00 122.01 ? 427  GLU A OE2 1 
ATOM   1067 N  N   . ASP A 1 165 ? -42.140 -25.520 -10.312 1.00 90.03  ? 428  ASP A N   1 
ATOM   1068 C  CA  . ASP A 1 165 ? -42.528 -24.304 -9.552  1.00 89.11  ? 428  ASP A CA  1 
ATOM   1069 C  C   . ASP A 1 165 ? -42.305 -23.061 -10.412 1.00 83.04  ? 428  ASP A C   1 
ATOM   1070 O  O   . ASP A 1 165 ? -41.141 -22.750 -10.707 1.00 77.44  ? 428  ASP A O   1 
ATOM   1071 C  CB  . ASP A 1 165 ? -41.773 -24.186 -8.229  1.00 92.70  ? 428  ASP A CB  1 
ATOM   1072 C  CG  . ASP A 1 165 ? -42.298 -23.071 -7.342  1.00 94.90  ? 428  ASP A CG  1 
ATOM   1073 O  OD1 . ASP A 1 165 ? -42.874 -22.114 -7.886  1.00 86.48  ? 428  ASP A OD1 1 
ATOM   1074 O  OD2 . ASP A 1 165 ? -42.141 -23.177 -6.113  1.00 109.87 ? 428  ASP A OD2 1 
ATOM   1075 N  N   . SER A 1 166 ? -43.386 -22.355 -10.732 0.50 80.15  ? 429  SER A N   1 
ATOM   1076 C  CA  . SER A 1 166 ? -43.294 -21.139 -11.583 0.50 78.34  ? 429  SER A CA  1 
ATOM   1077 C  C   . SER A 1 166 ? -42.597 -20.001 -10.829 0.50 76.27  ? 429  SER A C   1 
ATOM   1078 O  O   . SER A 1 166 ? -42.262 -18.990 -11.478 0.50 75.89  ? 429  SER A O   1 
ATOM   1079 C  CB  . SER A 1 166 ? -44.656 -20.720 -12.064 0.50 82.00  ? 429  SER A CB  1 
ATOM   1080 O  OG  . SER A 1 166 ? -45.308 -21.794 -12.725 0.50 84.19  ? 429  SER A OG  1 
ATOM   1081 N  N   . GLY A 1 167 ? -42.407 -20.151 -9.514  0.50 75.84  ? 430  GLY A N   1 
ATOM   1082 C  CA  . GLY A 1 167 ? -41.633 -19.217 -8.673  0.50 72.96  ? 430  GLY A CA  1 
ATOM   1083 C  C   . GLY A 1 167 ? -40.166 -19.224 -9.063  0.50 73.04  ? 430  GLY A C   1 
ATOM   1084 O  O   . GLY A 1 167 ? -39.588 -18.133 -9.208  0.50 72.78  ? 430  GLY A O   1 
ATOM   1085 N  N   . PHE A 1 168 ? -39.596 -20.421 -9.231  0.50 74.27  ? 431  PHE A N   1 
ATOM   1086 C  CA  . PHE A 1 168 ? -38.222 -20.669 -9.742  0.50 75.22  ? 431  PHE A CA  1 
ATOM   1087 C  C   . PHE A 1 168 ? -37.994 -19.856 -11.022 0.50 73.37  ? 431  PHE A C   1 
ATOM   1088 O  O   . PHE A 1 168 ? -37.047 -19.044 -11.056 0.50 71.74  ? 431  PHE A O   1 
ATOM   1089 C  CB  . PHE A 1 168 ? -38.017 -22.165 -9.994  0.50 79.32  ? 431  PHE A CB  1 
ATOM   1090 C  CG  . PHE A 1 168 ? -36.753 -22.522 -10.734 0.50 80.70  ? 431  PHE A CG  1 
ATOM   1091 C  CD1 . PHE A 1 168 ? -35.565 -22.731 -10.052 0.50 81.51  ? 431  PHE A CD1 1 
ATOM   1092 C  CD2 . PHE A 1 168 ? -36.755 -22.662 -12.113 0.50 83.13  ? 431  PHE A CD2 1 
ATOM   1093 C  CE1 . PHE A 1 168 ? -34.406 -23.064 -10.733 0.50 83.51  ? 431  PHE A CE1 1 
ATOM   1094 C  CE2 . PHE A 1 168 ? -35.595 -22.995 -12.794 0.50 83.61  ? 431  PHE A CE2 1 
ATOM   1095 C  CZ  . PHE A 1 168 ? -34.423 -23.196 -12.102 0.50 85.36  ? 431  PHE A CZ  1 
ATOM   1096 N  N   . TRP A 1 169 ? -38.844 -20.066 -12.034 1.00 74.52  ? 432  TRP A N   1 
ATOM   1097 C  CA  . TRP A 1 169 ? -38.719 -19.400 -13.368 1.00 71.02  ? 432  TRP A CA  1 
ATOM   1098 C  C   . TRP A 1 169 ? -38.759 -17.863 -13.255 1.00 73.20  ? 432  TRP A C   1 
ATOM   1099 O  O   . TRP A 1 169 ? -38.110 -17.172 -14.068 1.00 70.91  ? 432  TRP A O   1 
ATOM   1100 C  CB  . TRP A 1 169 ? -39.755 -19.945 -14.359 1.00 61.49  ? 432  TRP A CB  1 
ATOM   1101 C  CG  . TRP A 1 169 ? -39.530 -21.389 -14.673 1.00 62.85  ? 432  TRP A CG  1 
ATOM   1102 C  CD1 . TRP A 1 169 ? -40.335 -22.416 -14.296 1.00 65.75  ? 432  TRP A CD1 1 
ATOM   1103 C  CD2 . TRP A 1 169 ? -38.403 -21.995 -15.346 1.00 63.80  ? 432  TRP A CD2 1 
ATOM   1104 N  NE1 . TRP A 1 169 ? -39.807 -23.608 -14.704 1.00 65.24  ? 432  TRP A NE1 1 
ATOM   1105 C  CE2 . TRP A 1 169 ? -38.625 -23.388 -15.354 1.00 60.88  ? 432  TRP A CE2 1 
ATOM   1106 C  CE3 . TRP A 1 169 ? -37.239 -21.512 -15.952 1.00 65.09  ? 432  TRP A CE3 1 
ATOM   1107 C  CZ2 . TRP A 1 169 ? -37.740 -24.298 -15.932 1.00 59.99  ? 432  TRP A CZ2 1 
ATOM   1108 C  CZ3 . TRP A 1 169 ? -36.370 -22.410 -16.540 1.00 66.37  ? 432  TRP A CZ3 1 
ATOM   1109 C  CH2 . TRP A 1 169 ? -36.617 -23.784 -16.533 1.00 63.06  ? 432  TRP A CH2 1 
ATOM   1110 N  N   . GLU A 1 170 ? -39.486 -17.345 -12.260 0.50 73.80  ? 433  GLU A N   1 
ATOM   1111 C  CA  . GLU A 1 170 ? -39.604 -15.888 -11.981 0.50 74.29  ? 433  GLU A CA  1 
ATOM   1112 C  C   . GLU A 1 170 ? -38.261 -15.390 -11.433 0.50 70.09  ? 433  GLU A C   1 
ATOM   1113 O  O   . GLU A 1 170 ? -37.904 -14.228 -11.704 0.50 70.88  ? 433  GLU A O   1 
ATOM   1114 C  CB  . GLU A 1 170 ? -40.780 -15.639 -11.034 0.50 76.12  ? 433  GLU A CB  1 
ATOM   1115 C  CG  . GLU A 1 170 ? -42.074 -16.267 -11.528 0.50 79.27  ? 433  GLU A CG  1 
ATOM   1116 C  CD  . GLU A 1 170 ? -43.248 -16.227 -10.562 0.50 83.32  ? 433  GLU A CD  1 
ATOM   1117 O  OE1 . GLU A 1 170 ? -43.571 -15.125 -10.068 0.50 84.60  ? 433  GLU A OE1 1 
ATOM   1118 O  OE2 . GLU A 1 170 ? -43.842 -17.300 -10.312 0.50 81.87  ? 433  GLU A OE2 1 
ATOM   1119 N  N   . LEU A 1 171 ? -37.542 -16.253 -10.710 0.50 70.01  ? 434  LEU A N   1 
ATOM   1120 C  CA  . LEU A 1 171 ? -36.156 -15.998 -10.230 0.50 69.70  ? 434  LEU A CA  1 
ATOM   1121 C  C   . LEU A 1 171 ? -35.215 -15.977 -11.441 0.50 67.45  ? 434  LEU A C   1 
ATOM   1122 O  O   . LEU A 1 171 ? -34.428 -15.016 -11.569 0.50 61.99  ? 434  LEU A O   1 
ATOM   1123 C  CB  . LEU A 1 171 ? -35.761 -17.090 -9.229  0.50 69.64  ? 434  LEU A CB  1 
ATOM   1124 C  CG  . LEU A 1 171 ? -36.583 -17.134 -7.940  0.50 71.02  ? 434  LEU A CG  1 
ATOM   1125 C  CD1 . LEU A 1 171 ? -35.990 -18.133 -6.958  0.50 71.58  ? 434  LEU A CD1 1 
ATOM   1126 C  CD2 . LEU A 1 171 ? -36.680 -15.755 -7.302  0.50 70.61  ? 434  LEU A CD2 1 
ATOM   1127 N  N   . VAL A 1 172 ? -35.317 -16.988 -12.309 0.50 67.46  ? 435  VAL A N   1 
ATOM   1128 C  CA  . VAL A 1 172 ? -34.540 -17.088 -13.580 0.50 64.13  ? 435  VAL A CA  1 
ATOM   1129 C  C   . VAL A 1 172 ? -34.706 -15.776 -14.352 0.50 63.43  ? 435  VAL A C   1 
ATOM   1130 O  O   . VAL A 1 172 ? -33.681 -15.187 -14.752 0.50 61.68  ? 435  VAL A O   1 
ATOM   1131 C  CB  . VAL A 1 172 ? -34.989 -18.303 -14.411 0.50 66.04  ? 435  VAL A CB  1 
ATOM   1132 C  CG1 . VAL A 1 172 ? -34.198 -18.423 -15.704 0.50 67.14  ? 435  VAL A CG1 1 
ATOM   1133 C  CG2 . VAL A 1 172 ? -34.908 -19.593 -13.606 0.50 66.41  ? 435  VAL A CG2 1 
ATOM   1134 N  N   . ASP A 1 173 ? -35.952 -15.320 -14.521 0.50 66.45  ? 436  ASP A N   1 
ATOM   1135 C  CA  . ASP A 1 173 ? -36.301 -14.096 -15.291 0.50 66.79  ? 436  ASP A CA  1 
ATOM   1136 C  C   . ASP A 1 173 ? -35.522 -12.900 -14.727 0.50 65.17  ? 436  ASP A C   1 
ATOM   1137 O  O   . ASP A 1 173 ? -34.946 -12.139 -15.528 0.50 63.14  ? 436  ASP A O   1 
ATOM   1138 C  CB  . ASP A 1 173 ? -37.813 -13.846 -15.286 0.50 70.90  ? 436  ASP A CB  1 
ATOM   1139 C  CG  . ASP A 1 173 ? -38.605 -14.833 -16.130 0.50 73.91  ? 436  ASP A CG  1 
ATOM   1140 O  OD1 . ASP A 1 173 ? -38.055 -15.315 -17.145 0.50 72.71  ? 436  ASP A OD1 1 
ATOM   1141 O  OD2 . ASP A 1 173 ? -39.767 -15.119 -15.762 0.50 76.77  ? 436  ASP A OD2 1 
ATOM   1142 N  N   . LYS A 1 174 ? -35.509 -12.732 -13.402 0.50 66.40  ? 437  LYS A N   1 
ATOM   1143 C  CA  . LYS A 1 174 ? -34.827 -11.590 -12.734 0.50 66.02  ? 437  LYS A CA  1 
ATOM   1144 C  C   . LYS A 1 174 ? -33.347 -11.604 -13.135 0.50 63.21  ? 437  LYS A C   1 
ATOM   1145 O  O   . LYS A 1 174 ? -32.873 -10.590 -13.694 0.50 59.11  ? 437  LYS A O   1 
ATOM   1146 C  CB  . LYS A 1 174 ? -35.003 -11.661 -11.215 0.50 69.45  ? 437  LYS A CB  1 
ATOM   1147 C  CG  . LYS A 1 174 ? -34.370 -10.512 -10.441 0.50 72.56  ? 437  LYS A CG  1 
ATOM   1148 C  CD  . LYS A 1 174 ? -34.622 -10.568 -8.946  0.50 73.98  ? 437  LYS A CD  1 
ATOM   1149 C  CE  . LYS A 1 174 ? -33.862 -9.508  -8.177  0.50 74.71  ? 437  LYS A CE  1 
ATOM   1150 N  NZ  . LYS A 1 174 ? -34.132 -9.593  -6.722  0.50 76.67  ? 437  LYS A NZ  1 
ATOM   1151 N  N   . GLU A 1 175 ? -32.658 -12.721 -12.876 0.50 61.50  ? 438  GLU A N   1 
ATOM   1152 C  CA  . GLU A 1 175 ? -31.232 -12.936 -13.246 0.50 60.69  ? 438  GLU A CA  1 
ATOM   1153 C  C   . GLU A 1 175 ? -31.054 -12.703 -14.749 0.50 56.17  ? 438  GLU A C   1 
ATOM   1154 O  O   . GLU A 1 175 ? -30.119 -11.967 -15.129 0.50 55.84  ? 438  GLU A O   1 
ATOM   1155 C  CB  . GLU A 1 175 ? -30.786 -14.347 -12.862 0.50 64.23  ? 438  GLU A CB  1 
ATOM   1156 C  CG  . GLU A 1 175 ? -29.930 -14.383 -11.612 0.50 67.54  ? 438  GLU A CG  1 
ATOM   1157 C  CD  . GLU A 1 175 ? -28.616 -13.641 -11.753 0.50 68.18  ? 438  GLU A CD  1 
ATOM   1158 O  OE1 . GLU A 1 175 ? -27.711 -14.171 -12.420 0.50 74.44  ? 438  GLU A OE1 1 
ATOM   1159 O  OE2 . GLU A 1 175 ? -28.510 -12.532 -11.209 0.50 71.59  ? 438  GLU A OE2 1 
ATOM   1160 N  N   . ARG A 1 176 ? -31.913 -13.320 -15.565 0.50 55.72  ? 439  ARG A N   1 
ATOM   1161 C  CA  . ARG A 1 176 ? -31.887 -13.208 -17.048 0.50 56.98  ? 439  ARG A CA  1 
ATOM   1162 C  C   . ARG A 1 176 ? -31.885 -11.724 -17.431 0.50 56.67  ? 439  ARG A C   1 
ATOM   1163 O  O   . ARG A 1 176 ? -30.931 -11.291 -18.110 0.50 55.61  ? 439  ARG A O   1 
ATOM   1164 C  CB  . ARG A 1 176 ? -33.074 -13.957 -17.657 0.50 58.25  ? 439  ARG A CB  1 
ATOM   1165 C  CG  . ARG A 1 176 ? -33.014 -14.077 -19.173 0.50 60.41  ? 439  ARG A CG  1 
ATOM   1166 C  CD  . ARG A 1 176 ? -33.876 -15.214 -19.679 0.50 60.77  ? 439  ARG A CD  1 
ATOM   1167 N  NE  . ARG A 1 176 ? -33.952 -15.205 -21.131 0.50 67.67  ? 439  ARG A NE  1 
ATOM   1168 C  CZ  . ARG A 1 176 ? -34.642 -16.078 -21.854 0.50 71.16  ? 439  ARG A CZ  1 
ATOM   1169 N  NH1 . ARG A 1 176 ? -35.311 -17.048 -21.250 0.50 73.19  ? 439  ARG A NH1 1 
ATOM   1170 N  NH2 . ARG A 1 176 ? -34.650 -15.986 -23.173 0.50 68.64  ? 439  ARG A NH2 1 
ATOM   1171 N  N   . ASN A 1 177 ? -32.898 -10.970 -16.987 1.00 57.64  ? 440  ASN A N   1 
ATOM   1172 C  CA  . ASN A 1 177 ? -32.995 -9.506  -17.255 1.00 56.79  ? 440  ASN A CA  1 
ATOM   1173 C  C   . ASN A 1 177 ? -31.740 -8.790  -16.731 1.00 51.52  ? 440  ASN A C   1 
ATOM   1174 O  O   . ASN A 1 177 ? -31.206 -7.935  -17.461 1.00 54.80  ? 440  ASN A O   1 
ATOM   1175 C  CB  . ASN A 1 177 ? -34.325 -8.931  -16.745 1.00 63.19  ? 440  ASN A CB  1 
ATOM   1176 C  CG  . ASN A 1 177 ? -35.468 -9.322  -17.660 1.00 67.42  ? 440  ASN A CG  1 
ATOM   1177 O  OD1 . ASN A 1 177 ? -35.535 -8.881  -18.811 1.00 72.18  ? 440  ASN A OD1 1 
ATOM   1178 N  ND2 . ASN A 1 177 ? -36.330 -10.209 -17.194 1.00 68.36  ? 440  ASN A ND2 1 
ATOM   1179 N  N   . LEU A 1 178 ? -31.200 -9.190  -15.577 1.00 56.44  ? 441  LEU A N   1 
ATOM   1180 C  CA  . LEU A 1 178 ? -29.914 -8.630  -15.071 1.00 61.44  ? 441  LEU A CA  1 
ATOM   1181 C  C   . LEU A 1 178 ? -28.762 -8.938  -16.044 1.00 60.74  ? 441  LEU A C   1 
ATOM   1182 O  O   . LEU A 1 178 ? -27.953 -8.005  -16.305 1.00 61.29  ? 441  LEU A O   1 
ATOM   1183 C  CB  . LEU A 1 178 ? -29.631 -9.155  -13.660 1.00 67.71  ? 441  LEU A CB  1 
ATOM   1184 C  CG  . LEU A 1 178 ? -30.507 -8.557  -12.560 1.00 70.77  ? 441  LEU A CG  1 
ATOM   1185 C  CD1 . LEU A 1 178 ? -30.456 -9.412  -11.296 1.00 76.26  ? 441  LEU A CD1 1 
ATOM   1186 C  CD2 . LEU A 1 178 ? -30.093 -7.118  -12.269 1.00 71.87  ? 441  LEU A CD2 1 
ATOM   1187 N  N   . HIS A 1 179 ? -28.672 -10.160 -16.586 1.00 58.76  ? 442  HIS A N   1 
ATOM   1188 C  CA  . HIS A 1 179 ? -27.601 -10.517 -17.570 1.00 61.35  ? 442  HIS A CA  1 
ATOM   1189 C  C   . HIS A 1 179 ? -27.718 -9.605  -18.812 1.00 59.67  ? 442  HIS A C   1 
ATOM   1190 O  O   . HIS A 1 179 ? -26.691 -8.975  -19.164 1.00 59.21  ? 442  HIS A O   1 
ATOM   1191 C  CB  . HIS A 1 179 ? -27.583 -12.024 -17.916 1.00 54.78  ? 442  HIS A CB  1 
ATOM   1192 C  CG  . HIS A 1 179 ? -27.051 -12.926 -16.839 1.00 55.64  ? 442  HIS A CG  1 
ATOM   1193 N  ND1 . HIS A 1 179 ? -27.129 -14.317 -16.921 1.00 51.50  ? 442  HIS A ND1 1 
ATOM   1194 C  CD2 . HIS A 1 179 ? -26.461 -12.651 -15.652 1.00 49.69  ? 442  HIS A CD2 1 
ATOM   1195 C  CE1 . HIS A 1 179 ? -26.635 -14.843 -15.820 1.00 56.50  ? 442  HIS A CE1 1 
ATOM   1196 N  NE2 . HIS A 1 179 ? -26.193 -13.839 -15.030 1.00 47.78  ? 442  HIS A NE2 1 
ATOM   1197 N  N   . LEU A 1 180 ? -28.925 -9.464  -19.394 1.00 63.92  ? 443  LEU A N   1 
ATOM   1198 C  CA  . LEU A 1 180 ? -29.230 -8.548  -20.544 1.00 59.65  ? 443  LEU A CA  1 
ATOM   1199 C  C   . LEU A 1 180 ? -28.764 -7.128  -20.200 1.00 56.76  ? 443  LEU A C   1 
ATOM   1200 O  O   . LEU A 1 180 ? -28.255 -6.449  -21.091 1.00 60.22  ? 443  LEU A O   1 
ATOM   1201 C  CB  . LEU A 1 180 ? -30.727 -8.577  -20.890 1.00 58.52  ? 443  LEU A CB  1 
ATOM   1202 C  CG  . LEU A 1 180 ? -31.291 -9.924  -21.365 1.00 61.26  ? 443  LEU A CG  1 
ATOM   1203 C  CD1 . LEU A 1 180 ? -32.812 -9.955  -21.283 1.00 62.75  ? 443  LEU A CD1 1 
ATOM   1204 C  CD2 . LEU A 1 180 ? -30.845 -10.264 -22.779 1.00 59.77  ? 443  LEU A CD2 1 
ATOM   1205 N  N   . GLU A 1 181 ? -28.857 -6.745  -18.931 1.00 66.05  ? 444  GLU A N   1 
ATOM   1206 C  CA  . GLU A 1 181 ? -28.427 -5.436  -18.366 1.00 76.48  ? 444  GLU A CA  1 
ATOM   1207 C  C   . GLU A 1 181 ? -26.910 -5.466  -18.049 1.00 77.99  ? 444  GLU A C   1 
ATOM   1208 O  O   . GLU A 1 181 ? -26.379 -4.424  -17.610 1.00 76.67  ? 444  GLU A O   1 
ATOM   1209 C  CB  . GLU A 1 181 ? -29.349 -5.187  -17.161 1.00 81.94  ? 444  GLU A CB  1 
ATOM   1210 C  CG  . GLU A 1 181 ? -29.479 -3.757  -16.666 1.00 78.04  ? 444  GLU A CG  1 
ATOM   1211 C  CD  . GLU A 1 181 ? -30.133 -3.685  -15.288 1.00 81.49  ? 444  GLU A CD  1 
ATOM   1212 O  OE1 . GLU A 1 181 ? -29.616 -2.951  -14.417 1.00 74.90  ? 444  GLU A OE1 1 
ATOM   1213 O  OE2 . GLU A 1 181 ? -31.137 -4.404  -15.067 1.00 73.45  ? 444  GLU A OE2 1 
ATOM   1214 N  N   . GLY A 1 182 ? -26.216 -6.597  -18.265 1.00 76.08  ? 445  GLY A N   1 
ATOM   1215 C  CA  . GLY A 1 182 ? -24.748 -6.725  -18.118 1.00 62.27  ? 445  GLY A CA  1 
ATOM   1216 C  C   . GLY A 1 182 ? -24.289 -6.935  -16.676 1.00 58.04  ? 445  GLY A C   1 
ATOM   1217 O  O   . GLY A 1 182 ? -23.145 -6.592  -16.374 1.00 66.51  ? 445  GLY A O   1 
ATOM   1218 N  N   . LYS A 1 183 ? -25.128 -7.490  -15.805 1.00 51.35  ? 446  LYS A N   1 
ATOM   1219 C  CA  . LYS A 1 183 ? -24.849 -7.620  -14.348 1.00 56.60  ? 446  LYS A CA  1 
ATOM   1220 C  C   . LYS A 1 183 ? -25.279 -9.010  -13.864 1.00 46.44  ? 446  LYS A C   1 
ATOM   1221 O  O   . LYS A 1 183 ? -26.118 -9.620  -14.517 1.00 45.25  ? 446  LYS A O   1 
ATOM   1222 C  CB  . LYS A 1 183 ? -25.622 -6.567  -13.543 1.00 68.08  ? 446  LYS A CB  1 
ATOM   1223 C  CG  . LYS A 1 183 ? -25.610 -5.162  -14.126 1.00 73.19  ? 446  LYS A CG  1 
ATOM   1224 C  CD  . LYS A 1 183 ? -26.617 -4.245  -13.476 1.00 80.17  ? 446  LYS A CD  1 
ATOM   1225 C  CE  . LYS A 1 183 ? -26.509 -2.827  -13.990 1.00 85.96  ? 446  LYS A CE  1 
ATOM   1226 N  NZ  . LYS A 1 183 ? -27.140 -1.871  -13.053 1.00 94.59  ? 446  LYS A NZ  1 
ATOM   1227 N  N   . CYS A 1 184 ? -24.784 -9.462  -12.710 1.00 52.62  ? 447  CYS A N   1 
ATOM   1228 C  CA  . CYS A 1 184 ? -25.027 -10.832 -12.180 1.00 51.06  ? 447  CYS A CA  1 
ATOM   1229 C  C   . CYS A 1 184 ? -25.249 -10.751 -10.664 1.00 50.87  ? 447  CYS A C   1 
ATOM   1230 O  O   . CYS A 1 184 ? -24.493 -10.009 -9.994  1.00 54.40  ? 447  CYS A O   1 
ATOM   1231 C  CB  . CYS A 1 184 ? -23.859 -11.762 -12.548 1.00 49.58  ? 447  CYS A CB  1 
ATOM   1232 S  SG  . CYS A 1 184 ? -24.130 -13.508 -12.114 1.00 48.06  ? 447  CYS A SG  1 
ATOM   1233 N  N   . GLU A 1 185 ? -26.186 -11.536 -10.129 1.00 51.17  ? 448  GLU A N   1 
ATOM   1234 C  CA  . GLU A 1 185 ? -26.495 -11.535 -8.672  1.00 57.95  ? 448  GLU A CA  1 
ATOM   1235 C  C   . GLU A 1 185 ? -26.372 -12.906 -7.984  1.00 57.37  ? 448  GLU A C   1 
ATOM   1236 O  O   . GLU A 1 185 ? -25.933 -12.929 -6.812  1.00 59.34  ? 448  GLU A O   1 
ATOM   1237 C  CB  . GLU A 1 185 ? -27.904 -10.973 -8.437  1.00 68.53  ? 448  GLU A CB  1 
ATOM   1238 C  CG  . GLU A 1 185 ? -28.197 -10.600 -6.992  1.00 71.10  ? 448  GLU A CG  1 
ATOM   1239 C  CD  . GLU A 1 185 ? -29.620 -10.111 -6.767  1.00 78.49  ? 448  GLU A CD  1 
ATOM   1240 O  OE1 . GLU A 1 185 ? -29.854 -8.902  -6.960  1.00 74.77  ? 448  GLU A OE1 1 
ATOM   1241 O  OE2 . GLU A 1 185 ? -30.500 -10.946 -6.432  1.00 84.26  ? 448  GLU A OE2 1 
ATOM   1242 N  N   . THR A 1 186 ? -26.748 -13.995 -8.668  0.50 55.80  ? 449  THR A N   1 
ATOM   1243 C  CA  . THR A 1 186 ? -26.952 -15.339 -8.057  0.50 56.75  ? 449  THR A CA  1 
ATOM   1244 C  C   . THR A 1 186 ? -26.141 -16.442 -8.756  0.50 53.97  ? 449  THR A C   1 
ATOM   1245 O  O   . THR A 1 186 ? -26.279 -17.598 -8.321  0.50 55.76  ? 449  THR A O   1 
ATOM   1246 C  CB  . THR A 1 186 ? -28.440 -15.708 -8.066  0.50 58.74  ? 449  THR A CB  1 
ATOM   1247 O  OG1 . THR A 1 186 ? -28.865 -15.839 -9.423  0.50 61.56  ? 449  THR A OG1 1 
ATOM   1248 C  CG2 . THR A 1 186 ? -29.300 -14.681 -7.363  0.50 60.38  ? 449  THR A CG2 1 
ATOM   1249 N  N   . CYS A 1 187 ? -25.348 -16.129 -9.787  1.00 53.60  ? 450  CYS A N   1 
ATOM   1250 C  CA  . CYS A 1 187 ? -24.506 -17.146 -10.508 1.00 49.13  ? 450  CYS A CA  1 
ATOM   1251 C  C   . CYS A 1 187 ? -23.155 -17.336 -9.784  1.00 47.06  ? 450  CYS A C   1 
ATOM   1252 O  O   . CYS A 1 187 ? -22.120 -16.769 -10.220 1.00 45.84  ? 450  CYS A O   1 
ATOM   1253 C  CB  . CYS A 1 187 ? -24.357 -16.786 -11.978 1.00 47.38  ? 450  CYS A CB  1 
ATOM   1254 S  SG  . CYS A 1 187 ? -25.972 -16.599 -12.793 1.00 50.07  ? 450  CYS A SG  1 
ATOM   1255 N  N   . VAL A 1 188 ? -23.178 -18.133 -8.715  1.00 47.78  ? 451  VAL A N   1 
ATOM   1256 C  CA  . VAL A 1 188 ? -22.049 -18.402 -7.770  1.00 51.54  ? 451  VAL A CA  1 
ATOM   1257 C  C   . VAL A 1 188 ? -21.682 -19.900 -7.799  1.00 48.75  ? 451  VAL A C   1 
ATOM   1258 O  O   . VAL A 1 188 ? -22.581 -20.749 -7.675  1.00 47.59  ? 451  VAL A O   1 
ATOM   1259 C  CB  . VAL A 1 188 ? -22.470 -17.971 -6.351  1.00 52.91  ? 451  VAL A CB  1 
ATOM   1260 C  CG1 . VAL A 1 188 ? -21.468 -18.412 -5.288  1.00 57.74  ? 451  VAL A CG1 1 
ATOM   1261 C  CG2 . VAL A 1 188 ? -22.725 -16.474 -6.290  1.00 55.03  ? 451  VAL A CG2 1 
ATOM   1262 N  N   . TYR A 1 189 ? -20.398 -20.228 -7.890  1.00 52.77  ? 452  TYR A N   1 
ATOM   1263 C  CA  . TYR A 1 189 ? -19.925 -21.640 -7.871  1.00 58.40  ? 452  TYR A CA  1 
ATOM   1264 C  C   . TYR A 1 189 ? -19.751 -22.142 -6.434  1.00 60.50  ? 452  TYR A C   1 
ATOM   1265 O  O   . TYR A 1 189 ? -19.537 -21.312 -5.541  1.00 61.31  ? 452  TYR A O   1 
ATOM   1266 C  CB  . TYR A 1 189 ? -18.634 -21.775 -8.674  1.00 56.80  ? 452  TYR A CB  1 
ATOM   1267 C  CG  . TYR A 1 189 ? -18.849 -21.605 -10.152 1.00 58.39  ? 452  TYR A CG  1 
ATOM   1268 C  CD1 . TYR A 1 189 ? -19.625 -22.509 -10.860 1.00 61.72  ? 452  TYR A CD1 1 
ATOM   1269 C  CD2 . TYR A 1 189 ? -18.305 -20.529 -10.834 1.00 59.21  ? 452  TYR A CD2 1 
ATOM   1270 C  CE1 . TYR A 1 189 ? -19.847 -22.354 -12.216 1.00 62.80  ? 452  TYR A CE1 1 
ATOM   1271 C  CE2 . TYR A 1 189 ? -18.500 -20.370 -12.196 1.00 59.92  ? 452  TYR A CE2 1 
ATOM   1272 C  CZ  . TYR A 1 189 ? -19.291 -21.277 -12.880 1.00 58.67  ? 452  TYR A CZ  1 
ATOM   1273 O  OH  . TYR A 1 189 ? -19.504 -21.113 -14.215 1.00 71.49  ? 452  TYR A OH  1 
ATOM   1274 N  N   . ASN A 1 190 ? -19.860 -23.467 -6.252  1.00 73.07  ? 453  ASN A N   1 
ATOM   1275 C  CA  . ASN A 1 190 ? -19.566 -24.243 -5.010  1.00 75.45  ? 453  ASN A CA  1 
ATOM   1276 C  C   . ASN A 1 190 ? -18.539 -25.347 -5.297  1.00 73.44  ? 453  ASN A C   1 
ATOM   1277 O  O   . ASN A 1 190 ? -18.834 -26.201 -6.153  1.00 73.54  ? 453  ASN A O   1 
ATOM   1278 C  CB  . ASN A 1 190 ? -20.831 -24.892 -4.459  1.00 72.40  ? 453  ASN A CB  1 
ATOM   1279 C  CG  . ASN A 1 190 ? -21.892 -23.858 -4.182  1.00 67.56  ? 453  ASN A CG  1 
ATOM   1280 O  OD1 . ASN A 1 190 ? -21.801 -22.734 -4.652  1.00 74.57  ? 453  ASN A OD1 1 
ATOM   1281 N  ND2 . ASN A 1 190 ? -22.891 -24.222 -3.405  1.00 74.59  ? 453  ASN A ND2 1 
ATOM   1282 N  N   . MET A 1 191 ? -17.393 -25.334 -4.606  1.00 82.20  ? 454  MET A N   1 
ATOM   1283 C  CA  . MET A 1 191 ? -16.250 -26.257 -4.857  1.00 93.23  ? 454  MET A CA  1 
ATOM   1284 C  C   . MET A 1 191 ? -16.507 -27.589 -4.140  1.00 97.34  ? 454  MET A C   1 
ATOM   1285 O  O   . MET A 1 191 ? -17.243 -27.566 -3.139  1.00 102.36 ? 454  MET A O   1 
ATOM   1286 C  CB  . MET A 1 191 ? -14.945 -25.636 -4.353  1.00 99.47  ? 454  MET A CB  1 
ATOM   1287 C  CG  . MET A 1 191 ? -13.699 -26.326 -4.863  1.00 111.83 ? 454  MET A CG  1 
ATOM   1288 S  SD  . MET A 1 191 ? -12.370 -25.154 -5.274  1.00 132.65 ? 454  MET A SD  1 
ATOM   1289 C  CE  . MET A 1 191 ? -12.739 -24.839 -7.000  1.00 130.41 ? 454  MET A CE  1 
ATOM   1290 N  N   . MET A 1 192 ? -15.953 -28.698 -4.654  1.00 103.87 ? 455  MET A N   1 
ATOM   1291 C  CA  . MET A 1 192 ? -16.082 -30.076 -4.086  1.00 104.57 ? 455  MET A CA  1 
ATOM   1292 C  C   . MET A 1 192 ? -15.266 -31.073 -4.926  1.00 107.63 ? 455  MET A C   1 
ATOM   1293 O  O   . MET A 1 192 ? -15.693 -31.377 -6.066  1.00 95.49  ? 455  MET A O   1 
ATOM   1294 C  CB  . MET A 1 192 ? -17.549 -30.527 -4.033  1.00 104.40 ? 455  MET A CB  1 
ATOM   1295 C  CG  . MET A 1 192 ? -18.192 -30.385 -2.660  1.00 97.92  ? 455  MET A CG  1 
ATOM   1296 S  SD  . MET A 1 192 ? -19.979 -30.092 -2.738  1.00 97.68  ? 455  MET A SD  1 
ATOM   1297 C  CE  . MET A 1 192 ? -20.621 -31.762 -2.602  1.00 97.06  ? 455  MET A CE  1 
ATOM   1298 N  N   . SER A 1 208 ? -7.156  -35.295 -8.947  1.00 136.02 ? 471  SER A N   1 
ATOM   1299 C  CA  . SER A 1 208 ? -7.174  -34.553 -10.238 1.00 134.14 ? 471  SER A CA  1 
ATOM   1300 C  C   . SER A 1 208 ? -8.621  -34.268 -10.679 1.00 138.67 ? 471  SER A C   1 
ATOM   1301 O  O   . SER A 1 208 ? -8.858  -34.228 -11.904 1.00 139.47 ? 471  SER A O   1 
ATOM   1302 C  CB  . SER A 1 208 ? -6.407  -35.307 -11.294 1.00 126.08 ? 471  SER A CB  1 
ATOM   1303 O  OG  . SER A 1 208 ? -5.164  -35.760 -10.778 1.00 123.22 ? 471  SER A OG  1 
ATOM   1304 N  N   . ARG A 1 209 ? -9.544  -34.079 -9.722  1.00 139.11 ? 472  ARG A N   1 
ATOM   1305 C  CA  . ARG A 1 209 ? -10.985 -33.765 -9.959  1.00 135.66 ? 472  ARG A CA  1 
ATOM   1306 C  C   . ARG A 1 209 ? -11.414 -32.652 -8.986  1.00 129.73 ? 472  ARG A C   1 
ATOM   1307 O  O   . ARG A 1 209 ? -10.942 -32.659 -7.825  1.00 122.91 ? 472  ARG A O   1 
ATOM   1308 C  CB  . ARG A 1 209 ? -11.859 -35.022 -9.813  1.00 132.99 ? 472  ARG A CB  1 
ATOM   1309 C  CG  . ARG A 1 209 ? -11.387 -36.229 -10.620 1.00 132.99 ? 472  ARG A CG  1 
ATOM   1310 C  CD  . ARG A 1 209 ? -12.222 -37.491 -10.445 1.00 129.96 ? 472  ARG A CD  1 
ATOM   1311 N  NE  . ARG A 1 209 ? -12.462 -37.838 -9.046  1.00 134.78 ? 472  ARG A NE  1 
ATOM   1312 C  CZ  . ARG A 1 209 ? -11.673 -38.591 -8.275  1.00 130.71 ? 472  ARG A CZ  1 
ATOM   1313 N  NH1 . ARG A 1 209 ? -12.017 -38.815 -7.017  1.00 132.28 ? 472  ARG A NH1 1 
ATOM   1314 N  NH2 . ARG A 1 209 ? -10.552 -39.116 -8.740  1.00 121.70 ? 472  ARG A NH2 1 
ATOM   1315 N  N   . ALA A 1 210 ? -12.244 -31.715 -9.462  1.00 123.23 ? 473  ALA A N   1 
ATOM   1316 C  CA  . ALA A 1 210 ? -12.802 -30.570 -8.697  1.00 119.55 ? 473  ALA A CA  1 
ATOM   1317 C  C   . ALA A 1 210 ? -14.078 -30.070 -9.393  1.00 112.96 ? 473  ALA A C   1 
ATOM   1318 O  O   . ALA A 1 210 ? -13.952 -29.464 -10.473 1.00 110.13 ? 473  ALA A O   1 
ATOM   1319 C  CB  . ALA A 1 210 ? -11.765 -29.477 -8.575  1.00 116.08 ? 473  ALA A CB  1 
ATOM   1320 N  N   . ILE A 1 211 ? -15.256 -30.315 -8.800  1.00 109.26 ? 474  ILE A N   1 
ATOM   1321 C  CA  . ILE A 1 211 ? -16.592 -30.123 -9.451  1.00 96.73  ? 474  ILE A CA  1 
ATOM   1322 C  C   . ILE A 1 211 ? -17.279 -28.894 -8.849  1.00 93.77  ? 474  ILE A C   1 
ATOM   1323 O  O   . ILE A 1 211 ? -17.464 -28.849 -7.619  1.00 93.09  ? 474  ILE A O   1 
ATOM   1324 C  CB  . ILE A 1 211 ? -17.480 -31.375 -9.319  1.00 91.41  ? 474  ILE A CB  1 
ATOM   1325 C  CG1 . ILE A 1 211 ? -16.737 -32.647 -9.746  1.00 94.87  ? 474  ILE A CG1 1 
ATOM   1326 C  CG2 . ILE A 1 211 ? -18.785 -31.184 -10.088 1.00 80.10  ? 474  ILE A CG2 1 
ATOM   1327 C  CD1 . ILE A 1 211 ? -15.884 -33.288 -8.660  1.00 95.49  ? 474  ILE A CD1 1 
ATOM   1328 N  N   . TRP A 1 212 ? -17.654 -27.947 -9.709  1.00 93.58  ? 475  TRP A N   1 
ATOM   1329 C  CA  . TRP A 1 212 ? -18.217 -26.630 -9.323  1.00 95.23  ? 475  TRP A CA  1 
ATOM   1330 C  C   . TRP A 1 212 ? -19.719 -26.656 -9.602  1.00 88.81  ? 475  TRP A C   1 
ATOM   1331 O  O   . TRP A 1 212 ? -20.097 -26.280 -10.727 1.00 99.39  ? 475  TRP A O   1 
ATOM   1332 C  CB  . TRP A 1 212 ? -17.523 -25.490 -10.084 1.00 96.46  ? 475  TRP A CB  1 
ATOM   1333 C  CG  . TRP A 1 212 ? -16.027 -25.529 -10.070 1.00 97.30  ? 475  TRP A CG  1 
ATOM   1334 C  CD1 . TRP A 1 212 ? -15.219 -26.619 -9.927  1.00 102.34 ? 475  TRP A CD1 1 
ATOM   1335 C  CD2 . TRP A 1 212 ? -15.145 -24.414 -10.265 1.00 94.21  ? 475  TRP A CD2 1 
ATOM   1336 N  NE1 . TRP A 1 212 ? -13.905 -26.256 -9.991  1.00 101.77 ? 475  TRP A NE1 1 
ATOM   1337 C  CE2 . TRP A 1 212 ? -13.826 -24.910 -10.205 1.00 96.20  ? 475  TRP A CE2 1 
ATOM   1338 C  CE3 . TRP A 1 212 ? -15.341 -23.048 -10.476 1.00 84.08  ? 475  TRP A CE3 1 
ATOM   1339 C  CZ2 . TRP A 1 212 ? -12.710 -24.092 -10.353 1.00 94.81  ? 475  TRP A CZ2 1 
ATOM   1340 C  CZ3 . TRP A 1 212 ? -14.238 -22.240 -10.628 1.00 91.75  ? 475  TRP A CZ3 1 
ATOM   1341 C  CH2 . TRP A 1 212 ? -12.942 -22.758 -10.577 1.00 93.49  ? 475  TRP A CH2 1 
ATOM   1342 N  N   . TYR A 1 213 ? -20.525 -27.110 -8.636  1.00 80.50  ? 476  TYR A N   1 
ATOM   1343 C  CA  . TYR A 1 213 ? -22.008 -27.014 -8.666  1.00 77.81  ? 476  TYR A CA  1 
ATOM   1344 C  C   . TYR A 1 213 ? -22.417 -25.539 -8.540  1.00 73.97  ? 476  TYR A C   1 
ATOM   1345 O  O   . TYR A 1 213 ? -21.759 -24.779 -7.805  1.00 71.82  ? 476  TYR A O   1 
ATOM   1346 C  CB  . TYR A 1 213 ? -22.659 -27.831 -7.545  1.00 86.32  ? 476  TYR A CB  1 
ATOM   1347 C  CG  . TYR A 1 213 ? -22.322 -29.302 -7.531  1.00 94.38  ? 476  TYR A CG  1 
ATOM   1348 C  CD1 . TYR A 1 213 ? -23.041 -30.218 -8.284  1.00 105.64 ? 476  TYR A CD1 1 
ATOM   1349 C  CD2 . TYR A 1 213 ? -21.288 -29.784 -6.744  1.00 106.14 ? 476  TYR A CD2 1 
ATOM   1350 C  CE1 . TYR A 1 213 ? -22.734 -31.571 -8.263  1.00 109.63 ? 476  TYR A CE1 1 
ATOM   1351 C  CE2 . TYR A 1 213 ? -20.970 -31.133 -6.706  1.00 107.35 ? 476  TYR A CE2 1 
ATOM   1352 C  CZ  . TYR A 1 213 ? -21.695 -32.030 -7.469  1.00 111.01 ? 476  TYR A CZ  1 
ATOM   1353 O  OH  . TYR A 1 213 ? -21.375 -33.356 -7.434  1.00 111.84 ? 476  TYR A OH  1 
ATOM   1354 N  N   . MET A 1 214 ? -23.449 -25.140 -9.287  1.00 68.52  ? 477  MET A N   1 
ATOM   1355 C  CA  . MET A 1 214 ? -24.219 -23.881 -9.096  1.00 65.97  ? 477  MET A CA  1 
ATOM   1356 C  C   . MET A 1 214 ? -25.649 -24.286 -8.826  1.00 54.27  ? 477  MET A C   1 
ATOM   1357 O  O   . MET A 1 214 ? -25.950 -25.441 -9.096  1.00 54.48  ? 477  MET A O   1 
ATOM   1358 C  CB  . MET A 1 214 ? -24.268 -22.994 -10.337 1.00 67.48  ? 477  MET A CB  1 
ATOM   1359 C  CG  . MET A 1 214 ? -22.964 -22.877 -11.071 1.00 73.40  ? 477  MET A CG  1 
ATOM   1360 S  SD  . MET A 1 214 ? -23.231 -21.860 -12.533 1.00 69.99  ? 477  MET A SD  1 
ATOM   1361 C  CE  . MET A 1 214 ? -22.587 -20.294 -11.937 1.00 57.01  ? 477  MET A CE  1 
ATOM   1362 N  N   . TRP A 1 215 ? -26.497 -23.346 -8.413  1.00 52.99  ? 478  TRP A N   1 
ATOM   1363 C  CA  . TRP A 1 215 ? -27.946 -23.623 -8.275  1.00 54.96  ? 478  TRP A CA  1 
ATOM   1364 C  C   . TRP A 1 215 ? -28.573 -23.805 -9.668  1.00 60.18  ? 478  TRP A C   1 
ATOM   1365 O  O   . TRP A 1 215 ? -27.980 -23.370 -10.683 1.00 49.65  ? 478  TRP A O   1 
ATOM   1366 C  CB  . TRP A 1 215 ? -28.634 -22.563 -7.420  1.00 54.10  ? 478  TRP A CB  1 
ATOM   1367 C  CG  . TRP A 1 215 ? -29.031 -21.299 -8.104  1.00 56.67  ? 478  TRP A CG  1 
ATOM   1368 C  CD1 . TRP A 1 215 ? -28.212 -20.282 -8.492  1.00 64.43  ? 478  TRP A CD1 1 
ATOM   1369 C  CD2 . TRP A 1 215 ? -30.371 -20.872 -8.400  1.00 56.42  ? 478  TRP A CD2 1 
ATOM   1370 N  NE1 . TRP A 1 215 ? -28.944 -19.266 -9.048  1.00 72.00  ? 478  TRP A NE1 1 
ATOM   1371 C  CE2 . TRP A 1 215 ? -30.275 -19.596 -9.001  1.00 64.32  ? 478  TRP A CE2 1 
ATOM   1372 C  CE3 . TRP A 1 215 ? -31.632 -21.448 -8.233  1.00 56.51  ? 478  TRP A CE3 1 
ATOM   1373 C  CZ2 . TRP A 1 215 ? -31.394 -18.880 -9.426  1.00 61.05  ? 478  TRP A CZ2 1 
ATOM   1374 C  CZ3 . TRP A 1 215 ? -32.738 -20.745 -8.656  1.00 59.58  ? 478  TRP A CZ3 1 
ATOM   1375 C  CH2 . TRP A 1 215 ? -32.619 -19.479 -9.238  1.00 62.95  ? 478  TRP A CH2 1 
ATOM   1376 N  N   . LEU A 1 216 ? -29.710 -24.493 -9.708  1.00 61.29  ? 479  LEU A N   1 
ATOM   1377 C  CA  . LEU A 1 216 ? -30.334 -24.993 -10.954 1.00 62.03  ? 479  LEU A CA  1 
ATOM   1378 C  C   . LEU A 1 216 ? -30.602 -23.824 -11.907 1.00 63.15  ? 479  LEU A C   1 
ATOM   1379 O  O   . LEU A 1 216 ? -30.458 -24.029 -13.117 1.00 58.72  ? 479  LEU A O   1 
ATOM   1380 C  CB  . LEU A 1 216 ? -31.626 -25.728 -10.598 1.00 64.40  ? 479  LEU A CB  1 
ATOM   1381 C  CG  . LEU A 1 216 ? -32.092 -26.721 -11.652 1.00 67.04  ? 479  LEU A CG  1 
ATOM   1382 C  CD1 . LEU A 1 216 ? -31.048 -27.804 -11.848 1.00 66.87  ? 479  LEU A CD1 1 
ATOM   1383 C  CD2 . LEU A 1 216 ? -33.431 -27.328 -11.271 1.00 72.73  ? 479  LEU A CD2 1 
ATOM   1384 N  N   . GLY A 1 217 ? -30.955 -22.651 -11.370 1.00 55.96  ? 480  GLY A N   1 
ATOM   1385 C  CA  . GLY A 1 217 ? -31.295 -21.443 -12.141 1.00 57.34  ? 480  GLY A CA  1 
ATOM   1386 C  C   . GLY A 1 217 ? -30.138 -20.964 -13.000 1.00 57.02  ? 480  GLY A C   1 
ATOM   1387 O  O   . GLY A 1 217 ? -30.355 -20.738 -14.225 1.00 49.50  ? 480  GLY A O   1 
ATOM   1388 N  N   . ALA A 1 218 ? -28.957 -20.818 -12.392 1.00 55.11  ? 481  ALA A N   1 
ATOM   1389 C  CA  . ALA A 1 218 ? -27.683 -20.476 -13.079 1.00 52.81  ? 481  ALA A CA  1 
ATOM   1390 C  C   . ALA A 1 218 ? -27.370 -21.526 -14.150 1.00 50.84  ? 481  ALA A C   1 
ATOM   1391 O  O   . ALA A 1 218 ? -26.967 -21.106 -15.244 1.00 45.16  ? 481  ALA A O   1 
ATOM   1392 C  CB  . ALA A 1 218 ? -26.563 -20.377 -12.089 1.00 47.53  ? 481  ALA A CB  1 
ATOM   1393 N  N   . ARG A 1 219 ? -27.548 -22.818 -13.835 1.00 50.03  ? 482  ARG A N   1 
ATOM   1394 C  CA  . ARG A 1 219 ? -27.323 -23.953 -14.773 1.00 52.59  ? 482  ARG A CA  1 
ATOM   1395 C  C   . ARG A 1 219 ? -28.230 -23.778 -15.980 1.00 54.36  ? 482  ARG A C   1 
ATOM   1396 O  O   . ARG A 1 219 ? -27.766 -24.087 -17.102 1.00 44.31  ? 482  ARG A O   1 
ATOM   1397 C  CB  . ARG A 1 219 ? -27.632 -25.328 -14.181 1.00 51.77  ? 482  ARG A CB  1 
ATOM   1398 C  CG  . ARG A 1 219 ? -26.396 -26.195 -14.001 1.00 62.58  ? 482  ARG A CG  1 
ATOM   1399 C  CD  . ARG A 1 219 ? -25.507 -25.496 -12.990 1.00 62.88  ? 482  ARG A CD  1 
ATOM   1400 N  NE  . ARG A 1 219 ? -24.166 -26.027 -12.774 1.00 65.80  ? 482  ARG A NE  1 
ATOM   1401 C  CZ  . ARG A 1 219 ? -23.081 -25.687 -13.462 1.00 62.66  ? 482  ARG A CZ  1 
ATOM   1402 N  NH1 . ARG A 1 219 ? -23.160 -24.868 -14.498 1.00 60.30  ? 482  ARG A NH1 1 
ATOM   1403 N  NH2 . ARG A 1 219 ? -21.911 -26.188 -13.114 1.00 72.54  ? 482  ARG A NH2 1 
ATOM   1404 N  N   . PHE A 1 220 ? -29.469 -23.334 -15.754 1.00 48.59  ? 483  PHE A N   1 
ATOM   1405 C  CA  . PHE A 1 220 ? -30.438 -23.111 -16.852 1.00 47.94  ? 483  PHE A CA  1 
ATOM   1406 C  C   . PHE A 1 220 ? -29.885 -22.051 -17.799 1.00 43.99  ? 483  PHE A C   1 
ATOM   1407 O  O   . PHE A 1 220 ? -29.875 -22.285 -19.034 1.00 47.68  ? 483  PHE A O   1 
ATOM   1408 C  CB  . PHE A 1 220 ? -31.819 -22.651 -16.381 1.00 44.36  ? 483  PHE A CB  1 
ATOM   1409 C  CG  . PHE A 1 220 ? -32.680 -22.325 -17.566 1.00 40.76  ? 483  PHE A CG  1 
ATOM   1410 C  CD1 . PHE A 1 220 ? -33.104 -23.331 -18.413 1.00 45.46  ? 483  PHE A CD1 1 
ATOM   1411 C  CD2 . PHE A 1 220 ? -32.945 -21.016 -17.911 1.00 42.94  ? 483  PHE A CD2 1 
ATOM   1412 C  CE1 . PHE A 1 220 ? -33.844 -23.036 -19.544 1.00 51.72  ? 483  PHE A CE1 1 
ATOM   1413 C  CE2 . PHE A 1 220 ? -33.681 -20.717 -19.048 1.00 47.77  ? 483  PHE A CE2 1 
ATOM   1414 C  CZ  . PHE A 1 220 ? -34.133 -21.730 -19.859 1.00 49.57  ? 483  PHE A CZ  1 
ATOM   1415 N  N   . LEU A 1 221 ? -29.501 -20.904 -17.238 1.00 45.53  ? 484  LEU A N   1 
ATOM   1416 C  CA  . LEU A 1 221 ? -29.021 -19.732 -18.008 1.00 48.60  ? 484  LEU A CA  1 
ATOM   1417 C  C   . LEU A 1 221 ? -27.774 -20.123 -18.810 1.00 48.01  ? 484  LEU A C   1 
ATOM   1418 O  O   . LEU A 1 221 ? -27.662 -19.704 -20.001 1.00 42.45  ? 484  LEU A O   1 
ATOM   1419 C  CB  . LEU A 1 221 ? -28.773 -18.564 -17.052 1.00 49.64  ? 484  LEU A CB  1 
ATOM   1420 C  CG  . LEU A 1 221 ? -30.033 -17.842 -16.563 1.00 54.38  ? 484  LEU A CG  1 
ATOM   1421 C  CD1 . LEU A 1 221 ? -29.664 -16.649 -15.688 1.00 57.83  ? 484  LEU A CD1 1 
ATOM   1422 C  CD2 . LEU A 1 221 ? -30.903 -17.376 -17.726 1.00 56.37  ? 484  LEU A CD2 1 
ATOM   1423 N  N   . GLU A 1 222 ? -26.900 -20.944 -18.225 1.00 43.70  ? 485  GLU A N   1 
ATOM   1424 C  CA  . GLU A 1 222 ? -25.733 -21.496 -18.956 1.00 42.85  ? 485  GLU A CA  1 
ATOM   1425 C  C   . GLU A 1 222 ? -26.267 -22.365 -20.110 1.00 37.76  ? 485  GLU A C   1 
ATOM   1426 O  O   . GLU A 1 222 ? -25.814 -22.149 -21.234 1.00 36.45  ? 485  GLU A O   1 
ATOM   1427 C  CB  . GLU A 1 222 ? -24.787 -22.238 -18.003 1.00 40.90  ? 485  GLU A CB  1 
ATOM   1428 C  CG  . GLU A 1 222 ? -23.630 -22.872 -18.727 1.00 44.96  ? 485  GLU A CG  1 
ATOM   1429 C  CD  . GLU A 1 222 ? -22.739 -23.755 -17.873 1.00 49.38  ? 485  GLU A CD  1 
ATOM   1430 O  OE1 . GLU A 1 222 ? -21.532 -23.469 -17.793 1.00 45.08  ? 485  GLU A OE1 1 
ATOM   1431 O  OE2 . GLU A 1 222 ? -23.242 -24.731 -17.340 1.00 44.12  ? 485  GLU A OE2 1 
ATOM   1432 N  N   . PHE A 1 223 ? -27.217 -23.283 -19.862 1.00 36.76  ? 486  PHE A N   1 
ATOM   1433 C  CA  . PHE A 1 223 ? -27.748 -24.248 -20.866 1.00 41.30  ? 486  PHE A CA  1 
ATOM   1434 C  C   . PHE A 1 223 ? -28.460 -23.508 -22.007 1.00 42.63  ? 486  PHE A C   1 
ATOM   1435 O  O   . PHE A 1 223 ? -28.307 -23.898 -23.195 1.00 37.66  ? 486  PHE A O   1 
ATOM   1436 C  CB  . PHE A 1 223 ? -28.681 -25.249 -20.198 1.00 40.25  ? 486  PHE A CB  1 
ATOM   1437 C  CG  . PHE A 1 223 ? -29.406 -26.180 -21.135 1.00 42.90  ? 486  PHE A CG  1 
ATOM   1438 C  CD1 . PHE A 1 223 ? -28.757 -27.258 -21.706 1.00 40.34  ? 486  PHE A CD1 1 
ATOM   1439 C  CD2 . PHE A 1 223 ? -30.754 -25.998 -21.404 1.00 42.48  ? 486  PHE A CD2 1 
ATOM   1440 C  CE1 . PHE A 1 223 ? -29.433 -28.109 -22.562 1.00 45.57  ? 486  PHE A CE1 1 
ATOM   1441 C  CE2 . PHE A 1 223 ? -31.433 -26.863 -22.240 1.00 39.81  ? 486  PHE A CE2 1 
ATOM   1442 C  CZ  . PHE A 1 223 ? -30.777 -27.923 -22.815 1.00 45.00  ? 486  PHE A CZ  1 
ATOM   1443 N  N   . GLU A 1 224 ? -29.171 -22.442 -21.657 1.00 40.94  ? 487  GLU A N   1 
ATOM   1444 C  CA  . GLU A 1 224 ? -29.976 -21.632 -22.611 1.00 45.08  ? 487  GLU A CA  1 
ATOM   1445 C  C   . GLU A 1 224 ? -29.028 -21.030 -23.652 1.00 45.40  ? 487  GLU A C   1 
ATOM   1446 O  O   . GLU A 1 224 ? -29.365 -21.023 -24.875 1.00 46.20  ? 487  GLU A O   1 
ATOM   1447 C  CB  . GLU A 1 224 ? -30.757 -20.553 -21.848 1.00 48.30  ? 487  GLU A CB  1 
ATOM   1448 C  CG  . GLU A 1 224 ? -31.146 -19.340 -22.674 1.00 52.01  ? 487  GLU A CG  1 
ATOM   1449 C  CD  . GLU A 1 224 ? -32.217 -18.459 -22.041 1.00 54.08  ? 487  GLU A CD  1 
ATOM   1450 O  OE1 . GLU A 1 224 ? -33.410 -18.795 -22.191 1.00 51.72  ? 487  GLU A OE1 1 
ATOM   1451 O  OE2 . GLU A 1 224 ? -31.851 -17.435 -21.405 1.00 47.33  ? 487  GLU A OE2 1 
ATOM   1452 N  N   . ALA A 1 225 ? -27.862 -20.567 -23.198 1.00 39.63  ? 488  ALA A N   1 
ATOM   1453 C  CA  . ALA A 1 225 ? -26.937 -19.767 -24.019 1.00 39.45  ? 488  ALA A CA  1 
ATOM   1454 C  C   . ALA A 1 225 ? -25.952 -20.674 -24.749 1.00 38.29  ? 488  ALA A C   1 
ATOM   1455 O  O   . ALA A 1 225 ? -25.528 -20.238 -25.857 1.00 35.94  ? 488  ALA A O   1 
ATOM   1456 C  CB  . ALA A 1 225 ? -26.217 -18.742 -23.193 1.00 37.01  ? 488  ALA A CB  1 
ATOM   1457 N  N   . LEU A 1 226 ? -25.579 -21.828 -24.167 1.00 36.77  ? 489  LEU A N   1 
ATOM   1458 C  CA  . LEU A 1 226 ? -24.389 -22.599 -24.647 1.00 33.06  ? 489  LEU A CA  1 
ATOM   1459 C  C   . LEU A 1 226 ? -24.675 -24.085 -24.801 1.00 31.35  ? 489  LEU A C   1 
ATOM   1460 O  O   . LEU A 1 226 ? -23.790 -24.797 -25.344 1.00 31.28  ? 489  LEU A O   1 
ATOM   1461 C  CB  . LEU A 1 226 ? -23.205 -22.357 -23.710 1.00 32.90  ? 489  LEU A CB  1 
ATOM   1462 C  CG  . LEU A 1 226 ? -22.705 -20.917 -23.645 1.00 35.12  ? 489  LEU A CG  1 
ATOM   1463 C  CD1 . LEU A 1 226 ? -21.542 -20.768 -22.652 1.00 38.67  ? 489  LEU A CD1 1 
ATOM   1464 C  CD2 . LEU A 1 226 ? -22.238 -20.465 -25.019 1.00 40.40  ? 489  LEU A CD2 1 
ATOM   1465 N  N   . GLY A 1 227 ? -25.886 -24.544 -24.452 1.00 29.54  ? 490  GLY A N   1 
ATOM   1466 C  CA  . GLY A 1 227 ? -26.309 -25.943 -24.600 1.00 30.31  ? 490  GLY A CA  1 
ATOM   1467 C  C   . GLY A 1 227 ? -26.263 -26.444 -26.022 1.00 29.01  ? 490  GLY A C   1 
ATOM   1468 O  O   . GLY A 1 227 ? -26.082 -27.671 -26.227 1.00 31.38  ? 490  GLY A O   1 
ATOM   1469 N  N   . PHE A 1 228 ? -26.429 -25.553 -26.997 1.00 29.89  ? 491  PHE A N   1 
ATOM   1470 C  CA  . PHE A 1 228 ? -26.467 -25.942 -28.430 1.00 30.20  ? 491  PHE A CA  1 
ATOM   1471 C  C   . PHE A 1 228 ? -25.174 -26.686 -28.786 1.00 26.51  ? 491  PHE A C   1 
ATOM   1472 O  O   . PHE A 1 228 ? -25.205 -27.533 -29.671 1.00 27.46  ? 491  PHE A O   1 
ATOM   1473 C  CB  . PHE A 1 228 ? -26.674 -24.743 -29.362 1.00 28.50  ? 491  PHE A CB  1 
ATOM   1474 C  CG  . PHE A 1 228 ? -25.541 -23.768 -29.449 1.00 27.80  ? 491  PHE A CG  1 
ATOM   1475 C  CD1 . PHE A 1 228 ? -25.407 -22.753 -28.526 1.00 31.41  ? 491  PHE A CD1 1 
ATOM   1476 C  CD2 . PHE A 1 228 ? -24.569 -23.899 -30.408 1.00 29.59  ? 491  PHE A CD2 1 
ATOM   1477 C  CE1 . PHE A 1 228 ? -24.351 -21.867 -28.576 1.00 30.83  ? 491  PHE A CE1 1 
ATOM   1478 C  CE2 . PHE A 1 228 ? -23.511 -23.003 -30.465 1.00 29.86  ? 491  PHE A CE2 1 
ATOM   1479 C  CZ  . PHE A 1 228 ? -23.382 -22.005 -29.538 1.00 30.06  ? 491  PHE A CZ  1 
ATOM   1480 N  N   . LEU A 1 229 ? -24.048 -26.318 -28.183 1.00 30.30  ? 492  LEU A N   1 
ATOM   1481 C  CA  . LEU A 1 229 ? -22.739 -26.967 -28.512 1.00 30.96  ? 492  LEU A CA  1 
ATOM   1482 C  C   . LEU A 1 229 ? -22.867 -28.486 -28.354 1.00 26.89  ? 492  LEU A C   1 
ATOM   1483 O  O   . LEU A 1 229 ? -22.493 -29.223 -29.276 1.00 31.60  ? 492  LEU A O   1 
ATOM   1484 C  CB  . LEU A 1 229 ? -21.657 -26.376 -27.599 1.00 31.75  ? 492  LEU A CB  1 
ATOM   1485 C  CG  . LEU A 1 229 ? -21.199 -24.962 -27.952 1.00 33.06  ? 492  LEU A CG  1 
ATOM   1486 C  CD1 . LEU A 1 229 ? -20.215 -24.464 -26.933 1.00 35.30  ? 492  LEU A CD1 1 
ATOM   1487 C  CD2 . LEU A 1 229 ? -20.601 -24.878 -29.364 1.00 33.12  ? 492  LEU A CD2 1 
ATOM   1488 N  N   . ASN A 1 230 ? -23.465 -28.941 -27.263 1.00 29.58  ? 493  ASN A N   1 
ATOM   1489 C  CA  . ASN A 1 230 ? -23.693 -30.392 -27.010 1.00 29.17  ? 493  ASN A CA  1 
ATOM   1490 C  C   . ASN A 1 230 ? -24.996 -30.872 -27.648 1.00 29.89  ? 493  ASN A C   1 
ATOM   1491 O  O   . ASN A 1 230 ? -24.989 -31.933 -28.324 1.00 28.25  ? 493  ASN A O   1 
ATOM   1492 C  CB  . ASN A 1 230 ? -23.774 -30.700 -25.505 1.00 34.97  ? 493  ASN A CB  1 
ATOM   1493 C  CG  . ASN A 1 230 ? -23.860 -32.195 -25.255 1.00 40.03  ? 493  ASN A CG  1 
ATOM   1494 O  OD1 . ASN A 1 230 ? -24.847 -32.703 -24.707 1.00 44.13  ? 493  ASN A OD1 1 
ATOM   1495 N  ND2 . ASN A 1 230 ? -22.852 -32.924 -25.712 1.00 36.16  ? 493  ASN A ND2 1 
ATOM   1496 N  N   . GLU A 1 231 ? -26.094 -30.148 -27.442 1.00 32.37  ? 494  GLU A N   1 
ATOM   1497 C  CA  . GLU A 1 231 ? -27.417 -30.612 -27.946 1.00 30.94  ? 494  GLU A CA  1 
ATOM   1498 C  C   . GLU A 1 231 ? -27.368 -30.780 -29.473 1.00 31.51  ? 494  GLU A C   1 
ATOM   1499 O  O   . GLU A 1 231 ? -28.080 -31.685 -29.977 1.00 29.17  ? 494  GLU A O   1 
ATOM   1500 C  CB  . GLU A 1 231 ? -28.508 -29.612 -27.548 1.00 34.03  ? 494  GLU A CB  1 
ATOM   1501 C  CG  . GLU A 1 231 ? -28.825 -29.555 -26.060 1.00 36.84  ? 494  GLU A CG  1 
ATOM   1502 C  CD  . GLU A 1 231 ? -29.258 -30.881 -25.447 1.00 44.00  ? 494  GLU A CD  1 
ATOM   1503 O  OE1 . GLU A 1 231 ? -30.184 -31.515 -25.981 1.00 47.22  ? 494  GLU A OE1 1 
ATOM   1504 O  OE2 . GLU A 1 231 ? -28.621 -31.298 -24.482 1.00 52.38  ? 494  GLU A OE2 1 
ATOM   1505 N  N   . ASP A 1 232 ? -26.619 -29.935 -30.216 1.00 28.05  ? 495  ASP A N   1 
ATOM   1506 C  CA  . ASP A 1 232 ? -26.588 -29.975 -31.706 1.00 27.84  ? 495  ASP A CA  1 
ATOM   1507 C  C   . ASP A 1 232 ? -25.241 -30.541 -32.241 1.00 31.19  ? 495  ASP A C   1 
ATOM   1508 O  O   . ASP A 1 232 ? -24.969 -30.491 -33.484 1.00 29.04  ? 495  ASP A O   1 
ATOM   1509 C  CB  . ASP A 1 232 ? -26.897 -28.580 -32.249 1.00 31.56  ? 495  ASP A CB  1 
ATOM   1510 C  CG  . ASP A 1 232 ? -28.284 -28.052 -31.878 1.00 28.87  ? 495  ASP A CG  1 
ATOM   1511 O  OD1 . ASP A 1 232 ? -29.117 -28.868 -31.556 1.00 34.25  ? 495  ASP A OD1 1 
ATOM   1512 O  OD2 . ASP A 1 232 ? -28.455 -26.840 -31.836 1.00 31.18  ? 495  ASP A OD2 1 
ATOM   1513 N  N   . HIS A 1 233 ? -24.474 -31.187 -31.378 1.00 31.01  ? 496  HIS A N   1 
ATOM   1514 C  CA  . HIS A 1 233 ? -23.350 -32.089 -31.764 1.00 31.12  ? 496  HIS A CA  1 
ATOM   1515 C  C   . HIS A 1 233 ? -22.283 -31.316 -32.560 1.00 26.69  ? 496  HIS A C   1 
ATOM   1516 O  O   . HIS A 1 233 ? -21.872 -31.766 -33.626 1.00 27.92  ? 496  HIS A O   1 
ATOM   1517 C  CB  . HIS A 1 233 ? -23.874 -33.271 -32.583 1.00 32.94  ? 496  HIS A CB  1 
ATOM   1518 C  CG  . HIS A 1 233 ? -25.015 -33.974 -31.954 1.00 38.96  ? 496  HIS A CG  1 
ATOM   1519 N  ND1 . HIS A 1 233 ? -24.893 -34.665 -30.763 1.00 44.70  ? 496  HIS A ND1 1 
ATOM   1520 C  CD2 . HIS A 1 233 ? -26.324 -34.038 -32.317 1.00 45.02  ? 496  HIS A CD2 1 
ATOM   1521 C  CE1 . HIS A 1 233 ? -26.077 -35.170 -30.433 1.00 45.20  ? 496  HIS A CE1 1 
ATOM   1522 N  NE2 . HIS A 1 233 ? -26.966 -34.808 -31.391 1.00 44.54  ? 496  HIS A NE2 1 
ATOM   1523 N  N   . TRP A 1 234 ? -21.883 -30.168 -32.060 1.00 25.04  ? 497  TRP A N   1 
ATOM   1524 C  CA  . TRP A 1 234 ? -20.859 -29.301 -32.713 1.00 27.34  ? 497  TRP A CA  1 
ATOM   1525 C  C   . TRP A 1 234 ? -19.507 -30.054 -32.744 1.00 27.35  ? 497  TRP A C   1 
ATOM   1526 O  O   . TRP A 1 234 ? -18.751 -29.901 -33.719 1.00 24.15  ? 497  TRP A O   1 
ATOM   1527 C  CB  . TRP A 1 234 ? -20.771 -27.948 -31.993 1.00 27.32  ? 497  TRP A CB  1 
ATOM   1528 C  CG  . TRP A 1 234 ? -21.780 -26.952 -32.494 1.00 31.56  ? 497  TRP A CG  1 
ATOM   1529 C  CD1 . TRP A 1 234 ? -23.136 -27.144 -32.566 1.00 31.08  ? 497  TRP A CD1 1 
ATOM   1530 C  CD2 . TRP A 1 234 ? -21.529 -25.649 -33.076 1.00 29.68  ? 497  TRP A CD2 1 
ATOM   1531 N  NE1 . TRP A 1 234 ? -23.738 -26.041 -33.128 1.00 29.41  ? 497  TRP A NE1 1 
ATOM   1532 C  CE2 . TRP A 1 234 ? -22.796 -25.100 -33.419 1.00 29.78  ? 497  TRP A CE2 1 
ATOM   1533 C  CE3 . TRP A 1 234 ? -20.390 -24.851 -33.277 1.00 29.85  ? 497  TRP A CE3 1 
ATOM   1534 C  CZ2 . TRP A 1 234 ? -22.933 -23.827 -33.991 1.00 31.35  ? 497  TRP A CZ2 1 
ATOM   1535 C  CZ3 . TRP A 1 234 ? -20.528 -23.599 -33.848 1.00 33.00  ? 497  TRP A CZ3 1 
ATOM   1536 C  CH2 . TRP A 1 234 ? -21.793 -23.088 -34.183 1.00 30.89  ? 497  TRP A CH2 1 
ATOM   1537 N  N   . PHE A 1 235 ? -19.287 -30.949 -31.791 1.00 25.29  ? 498  PHE A N   1 
ATOM   1538 C  CA  . PHE A 1 235 ? -18.021 -31.733 -31.698 1.00 26.69  ? 498  PHE A CA  1 
ATOM   1539 C  C   . PHE A 1 235 ? -18.214 -33.180 -32.138 1.00 28.49  ? 498  PHE A C   1 
ATOM   1540 O  O   . PHE A 1 235 ? -17.288 -34.021 -31.863 1.00 25.76  ? 498  PHE A O   1 
ATOM   1541 C  CB  . PHE A 1 235 ? -17.455 -31.541 -30.293 1.00 26.20  ? 498  PHE A CB  1 
ATOM   1542 C  CG  . PHE A 1 235 ? -17.128 -30.102 -30.037 1.00 26.77  ? 498  PHE A CG  1 
ATOM   1543 C  CD1 . PHE A 1 235 ? -16.034 -29.504 -30.649 1.00 29.31  ? 498  PHE A CD1 1 
ATOM   1544 C  CD2 . PHE A 1 235 ? -17.974 -29.302 -29.276 1.00 28.63  ? 498  PHE A CD2 1 
ATOM   1545 C  CE1 . PHE A 1 235 ? -15.768 -28.154 -30.477 1.00 29.97  ? 498  PHE A CE1 1 
ATOM   1546 C  CE2 . PHE A 1 235 ? -17.707 -27.942 -29.125 1.00 29.09  ? 498  PHE A CE2 1 
ATOM   1547 C  CZ  . PHE A 1 235 ? -16.620 -27.368 -29.723 1.00 29.00  ? 498  PHE A CZ  1 
ATOM   1548 N  N   . SER A 1 236 ? -19.276 -33.507 -32.890 1.00 27.13  ? 499  SER A N   1 
ATOM   1549 C  CA  . SER A 1 236 ? -19.357 -34.796 -33.627 1.00 27.18  ? 499  SER A CA  1 
ATOM   1550 C  C   . SER A 1 236 ? -18.131 -34.921 -34.536 1.00 27.29  ? 499  SER A C   1 
ATOM   1551 O  O   . SER A 1 236 ? -17.606 -33.894 -34.954 1.00 26.90  ? 499  SER A O   1 
ATOM   1552 C  CB  . SER A 1 236 ? -20.605 -34.898 -34.485 1.00 29.54  ? 499  SER A CB  1 
ATOM   1553 O  OG  . SER A 1 236 ? -20.530 -33.995 -35.605 1.00 27.47  ? 499  SER A OG  1 
ATOM   1554 N  N   . ARG A 1 237 ? -17.762 -36.127 -34.943 1.00 26.38  ? 500  ARG A N   1 
ATOM   1555 C  CA  . ARG A 1 237 ? -16.635 -36.275 -35.902 1.00 27.73  ? 500  ARG A CA  1 
ATOM   1556 C  C   . ARG A 1 237 ? -17.004 -35.697 -37.283 1.00 32.67  ? 500  ARG A C   1 
ATOM   1557 O  O   . ARG A 1 237 ? -16.147 -35.086 -37.907 1.00 26.80  ? 500  ARG A O   1 
ATOM   1558 C  CB  . ARG A 1 237 ? -16.180 -37.735 -35.994 1.00 27.47  ? 500  ARG A CB  1 
ATOM   1559 C  CG  . ARG A 1 237 ? -14.819 -37.910 -36.646 1.00 27.90  ? 500  ARG A CG  1 
ATOM   1560 C  CD  . ARG A 1 237 ? -14.086 -39.145 -36.168 1.00 26.70  ? 500  ARG A CD  1 
ATOM   1561 N  NE  . ARG A 1 237 ? -12.722 -39.125 -36.664 1.00 24.29  ? 500  ARG A NE  1 
ATOM   1562 C  CZ  . ARG A 1 237 ? -11.715 -38.504 -36.065 1.00 24.58  ? 500  ARG A CZ  1 
ATOM   1563 N  NH1 . ARG A 1 237 ? -11.916 -37.852 -34.934 1.00 23.70  ? 500  ARG A NH1 1 
ATOM   1564 N  NH2 . ARG A 1 237 ? -10.509 -38.543 -36.599 1.00 26.06  ? 500  ARG A NH2 1 
ATOM   1565 N  N   . GLU A 1 238 ? -18.253 -35.871 -37.715 1.00 29.24  ? 501  GLU A N   1 
ATOM   1566 C  CA  . GLU A 1 238 ? -18.681 -35.380 -39.053 1.00 32.84  ? 501  GLU A CA  1 
ATOM   1567 C  C   . GLU A 1 238 ? -18.528 -33.858 -39.116 1.00 25.71  ? 501  GLU A C   1 
ATOM   1568 O  O   . GLU A 1 238 ? -18.088 -33.362 -40.134 1.00 28.89  ? 501  GLU A O   1 
ATOM   1569 C  CB  . GLU A 1 238 ? -20.114 -35.833 -39.356 1.00 36.54  ? 501  GLU A CB  1 
ATOM   1570 C  CG  . GLU A 1 238 ? -20.732 -35.142 -40.556 1.00 45.10  ? 501  GLU A CG  1 
ATOM   1571 C  CD  . GLU A 1 238 ? -22.179 -35.512 -40.836 1.00 58.00  ? 501  GLU A CD  1 
ATOM   1572 O  OE1 . GLU A 1 238 ? -22.876 -34.708 -41.478 1.00 68.96  ? 501  GLU A OE1 1 
ATOM   1573 O  OE2 . GLU A 1 238 ? -22.603 -36.606 -40.418 1.00 64.50  ? 501  GLU A OE2 1 
ATOM   1574 N  N   . ASN A 1 239 ? -18.846 -33.164 -38.031 1.00 28.75  ? 502  ASN A N   1 
ATOM   1575 C  CA  . ASN A 1 239 ? -18.809 -31.681 -38.034 1.00 28.96  ? 502  ASN A CA  1 
ATOM   1576 C  C   . ASN A 1 239 ? -17.433 -31.102 -37.688 1.00 32.49  ? 502  ASN A C   1 
ATOM   1577 O  O   . ASN A 1 239 ? -17.106 -30.075 -38.266 1.00 28.00  ? 502  ASN A O   1 
ATOM   1578 C  CB  . ASN A 1 239 ? -19.808 -31.094 -37.041 1.00 30.79  ? 502  ASN A CB  1 
ATOM   1579 C  CG  . ASN A 1 239 ? -20.035 -29.616 -37.270 1.00 31.86  ? 502  ASN A CG  1 
ATOM   1580 O  OD1 . ASN A 1 239 ? -20.476 -29.218 -38.342 1.00 31.81  ? 502  ASN A OD1 1 
ATOM   1581 N  ND2 . ASN A 1 239 ? -19.730 -28.800 -36.277 1.00 29.06  ? 502  ASN A ND2 1 
ATOM   1582 N  N   . SER A 1 240 ? -16.696 -31.710 -36.750 1.00 28.69  ? 503  SER A N   1 
ATOM   1583 C  CA  . SER A 1 240 ? -15.417 -31.128 -36.248 1.00 25.71  ? 503  SER A CA  1 
ATOM   1584 C  C   . SER A 1 240 ? -14.174 -31.841 -36.804 1.00 26.41  ? 503  SER A C   1 
ATOM   1585 O  O   . SER A 1 240 ? -13.099 -31.274 -36.638 1.00 25.97  ? 503  SER A O   1 
ATOM   1586 C  CB  . SER A 1 240 ? -15.415 -31.154 -34.743 1.00 28.60  ? 503  SER A CB  1 
ATOM   1587 O  OG  . SER A 1 240 ? -15.393 -32.488 -34.264 1.00 26.11  ? 503  SER A OG  1 
ATOM   1588 N  N   . LEU A 1 241 ? -14.326 -33.029 -37.391 1.00 24.84  ? 504  LEU A N   1 
ATOM   1589 C  CA  . LEU A 1 241 ? -13.218 -33.826 -37.996 1.00 29.03  ? 504  LEU A CA  1 
ATOM   1590 C  C   . LEU A 1 241 ? -12.302 -34.450 -36.926 1.00 25.08  ? 504  LEU A C   1 
ATOM   1591 O  O   . LEU A 1 241 ? -11.952 -35.614 -37.081 1.00 27.26  ? 504  LEU A O   1 
ATOM   1592 C  CB  . LEU A 1 241 ? -12.434 -32.962 -38.990 1.00 31.08  ? 504  LEU A CB  1 
ATOM   1593 C  CG  . LEU A 1 241 ? -13.258 -32.238 -40.054 1.00 37.34  ? 504  LEU A CG  1 
ATOM   1594 C  CD1 . LEU A 1 241 ? -12.359 -31.712 -41.160 1.00 39.49  ? 504  LEU A CD1 1 
ATOM   1595 C  CD2 . LEU A 1 241 ? -14.321 -33.152 -40.635 1.00 43.50  ? 504  LEU A CD2 1 
ATOM   1596 N  N   . SER A 1 242 ? -11.925 -33.686 -35.904 1.00 24.42  ? 505  SER A N   1 
ATOM   1597 C  CA  . SER A 1 242 ? -11.051 -34.195 -34.814 1.00 24.53  ? 505  SER A CA  1 
ATOM   1598 C  C   . SER A 1 242 ? -11.898 -34.760 -33.672 1.00 24.60  ? 505  SER A C   1 
ATOM   1599 O  O   . SER A 1 242 ? -11.420 -35.629 -32.956 1.00 20.73  ? 505  SER A O   1 
ATOM   1600 C  CB  . SER A 1 242 ? -10.140 -33.099 -34.312 1.00 25.42  ? 505  SER A CB  1 
ATOM   1601 O  OG  . SER A 1 242 ? -9.395  -32.517 -35.359 1.00 25.36  ? 505  SER A OG  1 
ATOM   1602 N  N   . GLY A 1 243 ? -13.119 -34.263 -33.537 1.00 24.26  ? 506  GLY A N   1 
ATOM   1603 C  CA  . GLY A 1 243 ? -13.975 -34.659 -32.412 1.00 20.89  ? 506  GLY A CA  1 
ATOM   1604 C  C   . GLY A 1 243 ? -14.517 -36.069 -32.472 1.00 22.40  ? 506  GLY A C   1 
ATOM   1605 O  O   . GLY A 1 243 ? -14.432 -36.690 -33.520 1.00 23.33  ? 506  GLY A O   1 
ATOM   1606 N  N   . VAL A 1 244 ? -15.053 -36.530 -31.351 1.00 22.77  ? 507  VAL A N   1 
ATOM   1607 C  CA  . VAL A 1 244 ? -15.647 -37.879 -31.230 1.00 26.57  ? 507  VAL A CA  1 
ATOM   1608 C  C   . VAL A 1 244 ? -16.939 -37.774 -30.391 1.00 26.97  ? 507  VAL A C   1 
ATOM   1609 O  O   . VAL A 1 244 ? -17.373 -38.791 -29.830 1.00 23.89  ? 507  VAL A O   1 
ATOM   1610 C  CB  . VAL A 1 244 ? -14.656 -38.884 -30.603 1.00 25.24  ? 507  VAL A CB  1 
ATOM   1611 C  CG1 . VAL A 1 244 ? -13.468 -39.141 -31.489 1.00 26.17  ? 507  VAL A CG1 1 
ATOM   1612 C  CG2 . VAL A 1 244 ? -14.236 -38.449 -29.202 1.00 27.43  ? 507  VAL A CG2 1 
ATOM   1613 N  N   . GLU A 1 245 ? -17.537 -36.592 -30.270 1.00 25.61  ? 508  GLU A N   1 
ATOM   1614 C  CA  . GLU A 1 245 ? -18.746 -36.441 -29.391 1.00 30.00  ? 508  GLU A CA  1 
ATOM   1615 C  C   . GLU A 1 245 ? -19.873 -37.305 -29.962 1.00 25.05  ? 508  GLU A C   1 
ATOM   1616 O  O   . GLU A 1 245 ? -20.091 -37.298 -31.183 1.00 26.00  ? 508  GLU A O   1 
ATOM   1617 C  CB  . GLU A 1 245 ? -19.233 -35.000 -29.264 1.00 31.02  ? 508  GLU A CB  1 
ATOM   1618 C  CG  . GLU A 1 245 ? -20.330 -34.817 -28.194 1.00 37.12  ? 508  GLU A CG  1 
ATOM   1619 C  CD  . GLU A 1 245 ? -21.758 -35.127 -28.641 1.00 41.63  ? 508  GLU A CD  1 
ATOM   1620 O  OE1 . GLU A 1 245 ? -22.082 -34.848 -29.815 1.00 49.52  ? 508  GLU A OE1 1 
ATOM   1621 O  OE2 . GLU A 1 245 ? -22.555 -35.670 -27.825 1.00 50.88  ? 508  GLU A OE2 1 
ATOM   1622 N  N   . GLY A 1 246 ? -20.491 -38.109 -29.115 1.00 30.51  ? 509  GLY A N   1 
ATOM   1623 C  CA  . GLY A 1 246 ? -21.557 -39.053 -29.514 1.00 30.65  ? 509  GLY A CA  1 
ATOM   1624 C  C   . GLY A 1 246 ? -21.085 -40.346 -30.173 1.00 30.55  ? 509  GLY A C   1 
ATOM   1625 O  O   . GLY A 1 246 ? -21.932 -41.130 -30.573 1.00 28.53  ? 509  GLY A O   1 
ATOM   1626 N  N   . GLU A 1 247 ? -19.763 -40.595 -30.152 0.50 28.23  ? 510  GLU A N   1 
ATOM   1627 C  CA  . GLU A 1 247 ? -19.132 -41.870 -30.591 0.50 28.72  ? 510  GLU A CA  1 
ATOM   1628 C  C   . GLU A 1 247 ? -19.001 -42.807 -29.388 0.50 28.08  ? 510  GLU A C   1 
ATOM   1629 O  O   . GLU A 1 247 ? -18.242 -42.479 -28.445 0.50 26.73  ? 510  GLU A O   1 
ATOM   1630 C  CB  . GLU A 1 247 ? -17.744 -41.657 -31.200 0.50 28.48  ? 510  GLU A CB  1 
ATOM   1631 C  CG  . GLU A 1 247 ? -17.747 -40.844 -32.483 0.50 29.82  ? 510  GLU A CG  1 
ATOM   1632 C  CD  . GLU A 1 247 ? -18.638 -41.377 -33.590 0.50 30.04  ? 510  GLU A CD  1 
ATOM   1633 O  OE1 . GLU A 1 247 ? -18.481 -42.545 -33.969 0.50 32.80  ? 510  GLU A OE1 1 
ATOM   1634 O  OE2 . GLU A 1 247 ? -19.502 -40.620 -34.058 0.50 31.89  ? 510  GLU A OE2 1 
ATOM   1635 N  N   . GLY A 1 248 ? -19.696 -43.942 -29.443 0.50 27.46  ? 511  GLY A N   1 
ATOM   1636 C  CA  . GLY A 1 248 ? -19.574 -45.009 -28.438 0.50 28.21  ? 511  GLY A CA  1 
ATOM   1637 C  C   . GLY A 1 248 ? -18.198 -45.649 -28.453 0.50 27.83  ? 511  GLY A C   1 
ATOM   1638 O  O   . GLY A 1 248 ? -17.511 -45.635 -29.496 0.50 24.53  ? 511  GLY A O   1 
ATOM   1639 N  N   A LEU A 1 249 ? -17.838 -46.249 -27.329 0.25 30.30  ? 512  LEU A N   1 
ATOM   1640 N  N   B LEU A 1 249 ? -17.799 -46.269 -27.328 0.25 29.82  ? 512  LEU A N   1 
ATOM   1641 C  CA  A LEU A 1 249 ? -16.595 -47.024 -27.155 0.25 30.71  ? 512  LEU A CA  1 
ATOM   1642 C  CA  B LEU A 1 249 ? -16.534 -47.034 -27.200 0.25 30.05  ? 512  LEU A CA  1 
ATOM   1643 C  C   A LEU A 1 249 ? -16.437 -48.022 -28.304 0.25 30.08  ? 512  LEU A C   1 
ATOM   1644 C  C   B LEU A 1 249 ? -16.413 -48.000 -28.371 0.25 29.69  ? 512  LEU A C   1 
ATOM   1645 O  O   A LEU A 1 249 ? -15.296 -48.414 -28.568 0.25 32.58  ? 512  LEU A O   1 
ATOM   1646 O  O   B LEU A 1 249 ? -15.280 -48.361 -28.704 0.25 31.97  ? 512  LEU A O   1 
ATOM   1647 C  CB  A LEU A 1 249 ? -16.702 -47.718 -25.797 0.25 32.18  ? 512  LEU A CB  1 
ATOM   1648 C  CB  B LEU A 1 249 ? -16.509 -47.803 -25.876 0.25 30.99  ? 512  LEU A CB  1 
ATOM   1649 C  CG  A LEU A 1 249 ? -15.392 -47.975 -25.074 0.25 30.53  ? 512  LEU A CG  1 
ATOM   1650 C  CG  B LEU A 1 249 ? -16.005 -47.017 -24.674 0.25 29.73  ? 512  LEU A CG  1 
ATOM   1651 C  CD1 A LEU A 1 249 ? -14.484 -46.750 -25.113 0.25 29.80  ? 512  LEU A CD1 1 
ATOM   1652 C  CD1 B LEU A 1 249 ? -16.228 -47.810 -23.402 0.25 29.61  ? 512  LEU A CD1 1 
ATOM   1653 C  CD2 A LEU A 1 249 ? -15.682 -48.403 -23.650 0.25 31.29  ? 512  LEU A CD2 1 
ATOM   1654 C  CD2 B LEU A 1 249 ? -14.530 -46.664 -24.849 0.25 29.31  ? 512  LEU A CD2 1 
ATOM   1655 N  N   . HIS A 1 250 ? -17.530 -48.444 -28.954 1.00 28.11  ? 513  HIS A N   1 
ATOM   1656 C  CA  . HIS A 1 250 ? -17.457 -49.406 -30.084 1.00 27.99  ? 513  HIS A CA  1 
ATOM   1657 C  C   . HIS A 1 250 ? -17.037 -48.750 -31.405 1.00 26.62  ? 513  HIS A C   1 
ATOM   1658 O  O   . HIS A 1 250 ? -16.892 -49.461 -32.415 1.00 28.42  ? 513  HIS A O   1 
ATOM   1659 C  CB  . HIS A 1 250 ? -18.830 -50.081 -30.295 1.00 31.85  ? 513  HIS A CB  1 
ATOM   1660 C  CG  . HIS A 1 250 ? -19.952 -49.117 -30.488 1.00 28.73  ? 513  HIS A CG  1 
ATOM   1661 N  ND1 . HIS A 1 250 ? -20.422 -48.336 -29.468 1.00 31.47  ? 513  HIS A ND1 1 
ATOM   1662 C  CD2 . HIS A 1 250 ? -20.696 -48.835 -31.578 1.00 30.98  ? 513  HIS A CD2 1 
ATOM   1663 C  CE1 . HIS A 1 250 ? -21.404 -47.565 -29.938 1.00 29.32  ? 513  HIS A CE1 1 
ATOM   1664 N  NE2 . HIS A 1 250 ? -21.594 -47.880 -31.233 1.00 30.39  ? 513  HIS A NE2 1 
ATOM   1665 N  N   . LYS A 1 251 ? -16.904 -47.419 -31.399 0.50 26.48  ? 514  LYS A N   1 
ATOM   1666 C  CA  . LYS A 1 251 ? -16.519 -46.600 -32.577 0.50 26.82  ? 514  LYS A CA  1 
ATOM   1667 C  C   . LYS A 1 251 ? -15.071 -46.114 -32.430 0.50 24.90  ? 514  LYS A C   1 
ATOM   1668 O  O   . LYS A 1 251 ? -14.408 -45.952 -33.469 0.50 24.07  ? 514  LYS A O   1 
ATOM   1669 C  CB  . LYS A 1 251 ? -17.461 -45.403 -32.705 0.50 29.99  ? 514  LYS A CB  1 
ATOM   1670 C  CG  . LYS A 1 251 ? -18.934 -45.782 -32.736 0.50 32.33  ? 514  LYS A CG  1 
ATOM   1671 C  CD  . LYS A 1 251 ? -19.374 -46.195 -34.098 0.50 35.42  ? 514  LYS A CD  1 
ATOM   1672 C  CE  . LYS A 1 251 ? -19.657 -44.990 -34.966 0.50 37.78  ? 514  LYS A CE  1 
ATOM   1673 N  NZ  . LYS A 1 251 ? -20.893 -45.186 -35.756 0.50 40.34  ? 514  LYS A NZ  1 
ATOM   1674 N  N   . LEU A 1 252 ? -14.606 -45.898 -31.196 1.00 23.51  ? 515  LEU A N   1 
ATOM   1675 C  CA  . LEU A 1 252 ? -13.333 -45.158 -30.947 1.00 22.73  ? 515  LEU A CA  1 
ATOM   1676 C  C   . LEU A 1 252 ? -12.139 -45.914 -31.513 1.00 22.25  ? 515  LEU A C   1 
ATOM   1677 O  O   . LEU A 1 252 ? -11.230 -45.246 -32.095 1.00 22.67  ? 515  LEU A O   1 
ATOM   1678 C  CB  . LEU A 1 252 ? -13.177 -44.871 -29.458 1.00 22.38  ? 515  LEU A CB  1 
ATOM   1679 C  CG  . LEU A 1 252 ? -14.218 -43.960 -28.831 1.00 22.78  ? 515  LEU A CG  1 
ATOM   1680 C  CD1 . LEU A 1 252 ? -13.840 -43.669 -27.390 1.00 24.84  ? 515  LEU A CD1 1 
ATOM   1681 C  CD2 . LEU A 1 252 ? -14.380 -42.655 -29.595 1.00 25.74  ? 515  LEU A CD2 1 
ATOM   1682 N  N   . GLY A 1 253 ? -12.154 -47.251 -31.446 1.00 20.41  ? 516  GLY A N   1 
ATOM   1683 C  CA  . GLY A 1 253 ? -11.020 -48.024 -31.972 1.00 21.85  ? 516  GLY A CA  1 
ATOM   1684 C  C   . GLY A 1 253 ? -10.954 -47.940 -33.487 1.00 23.55  ? 516  GLY A C   1 
ATOM   1685 O  O   . GLY A 1 253 ? -9.845  -47.759 -34.035 1.00 22.11  ? 516  GLY A O   1 
ATOM   1686 N  N   . TYR A 1 254 ? -12.102 -48.067 -34.158 1.00 22.95  ? 517  TYR A N   1 
ATOM   1687 C  CA  . TYR A 1 254 ? -12.172 -47.895 -35.616 1.00 23.09  ? 517  TYR A CA  1 
ATOM   1688 C  C   . TYR A 1 254 ? -11.695 -46.479 -36.010 1.00 23.79  ? 517  TYR A C   1 
ATOM   1689 O  O   . TYR A 1 254 ? -10.996 -46.364 -37.014 1.00 24.37  ? 517  TYR A O   1 
ATOM   1690 C  CB  . TYR A 1 254 ? -13.581 -48.130 -36.148 1.00 25.44  ? 517  TYR A CB  1 
ATOM   1691 C  CG  . TYR A 1 254 ? -14.050 -49.557 -36.162 1.00 22.37  ? 517  TYR A CG  1 
ATOM   1692 C  CD1 . TYR A 1 254 ? -13.504 -50.497 -37.046 1.00 24.85  ? 517  TYR A CD1 1 
ATOM   1693 C  CD2 . TYR A 1 254 ? -15.006 -49.981 -35.262 1.00 22.82  ? 517  TYR A CD2 1 
ATOM   1694 C  CE1 . TYR A 1 254 ? -13.959 -51.811 -37.077 1.00 23.93  ? 517  TYR A CE1 1 
ATOM   1695 C  CE2 . TYR A 1 254 ? -15.485 -51.287 -35.282 1.00 23.14  ? 517  TYR A CE2 1 
ATOM   1696 C  CZ  . TYR A 1 254 ? -14.964 -52.204 -36.189 1.00 24.37  ? 517  TYR A CZ  1 
ATOM   1697 O  OH  . TYR A 1 254 ? -15.489 -53.470 -36.221 1.00 24.45  ? 517  TYR A OH  1 
ATOM   1698 N  N   . ILE A 1 255 ? -12.064 -45.442 -35.266 1.00 24.46  ? 518  ILE A N   1 
ATOM   1699 C  CA  . ILE A 1 255 ? -11.600 -44.066 -35.547 1.00 23.98  ? 518  ILE A CA  1 
ATOM   1700 C  C   . ILE A 1 255 ? -10.063 -44.004 -35.448 1.00 24.49  ? 518  ILE A C   1 
ATOM   1701 O  O   . ILE A 1 255 ? -9.443  -43.450 -36.374 1.00 26.10  ? 518  ILE A O   1 
ATOM   1702 C  CB  . ILE A 1 255 ? -12.315 -43.062 -34.632 1.00 25.99  ? 518  ILE A CB  1 
ATOM   1703 C  CG1 . ILE A 1 255 ? -13.785 -42.961 -35.055 1.00 24.92  ? 518  ILE A CG1 1 
ATOM   1704 C  CG2 . ILE A 1 255 ? -11.600 -41.716 -34.641 1.00 24.80  ? 518  ILE A CG2 1 
ATOM   1705 C  CD1 . ILE A 1 255 ? -14.688 -42.293 -34.022 1.00 26.67  ? 518  ILE A CD1 1 
ATOM   1706 N  N   . LEU A 1 256 ? -9.467  -44.551 -34.398 1.00 25.38  ? 519  LEU A N   1 
ATOM   1707 C  CA  . LEU A 1 256 ? -7.988  -44.544 -34.242 1.00 25.57  ? 519  LEU A CA  1 
ATOM   1708 C  C   . LEU A 1 256 ? -7.323  -45.326 -35.376 1.00 27.43  ? 519  LEU A C   1 
ATOM   1709 O  O   . LEU A 1 256 ? -6.243  -44.881 -35.797 1.00 25.73  ? 519  LEU A O   1 
ATOM   1710 C  CB  . LEU A 1 256 ? -7.571  -45.142 -32.902 1.00 25.90  ? 519  LEU A CB  1 
ATOM   1711 C  CG  . LEU A 1 256 ? -7.937  -44.358 -31.650 1.00 28.03  ? 519  LEU A CG  1 
ATOM   1712 C  CD1 . LEU A 1 256 ? -7.317  -45.049 -30.456 1.00 29.42  ? 519  LEU A CD1 1 
ATOM   1713 C  CD2 . LEU A 1 256 ? -7.484  -42.897 -31.716 1.00 30.76  ? 519  LEU A CD2 1 
ATOM   1714 N  N   . ARG A 1 257 ? -7.885  -46.477 -35.786 1.00 25.91  ? 520  ARG A N   1 
ATOM   1715 C  CA  . ARG A 1 257 ? -7.340  -47.265 -36.926 1.00 29.22  ? 520  ARG A CA  1 
ATOM   1716 C  C   . ARG A 1 257 ? -7.447  -46.425 -38.216 1.00 28.61  ? 520  ARG A C   1 
ATOM   1717 O  O   . ARG A 1 257 ? -6.483  -46.432 -39.007 1.00 26.21  ? 520  ARG A O   1 
ATOM   1718 C  CB  . ARG A 1 257 ? -8.016  -48.628 -37.029 1.00 26.73  ? 520  ARG A CB  1 
ATOM   1719 C  CG  . ARG A 1 257 ? -7.425  -49.498 -38.131 1.00 28.71  ? 520  ARG A CG  1 
ATOM   1720 C  CD  . ARG A 1 257 ? -8.175  -50.801 -38.287 1.00 28.82  ? 520  ARG A CD  1 
ATOM   1721 N  NE  . ARG A 1 257 ? -9.494  -50.636 -38.886 1.00 30.79  ? 520  ARG A NE  1 
ATOM   1722 C  CZ  . ARG A 1 257 ? -10.271 -51.640 -39.287 1.00 27.54  ? 520  ARG A CZ  1 
ATOM   1723 N  NH1 . ARG A 1 257 ? -9.894  -52.885 -39.106 1.00 30.92  ? 520  ARG A NH1 1 
ATOM   1724 N  NH2 . ARG A 1 257 ? -11.427 -51.375 -39.832 1.00 29.26  ? 520  ARG A NH2 1 
ATOM   1725 N  N   . ASP A 1 258 ? -8.494  -45.618 -38.389 1.00 26.49  ? 521  ASP A N   1 
ATOM   1726 C  CA  . ASP A 1 258 ? -8.591  -44.763 -39.622 1.00 27.18  ? 521  ASP A CA  1 
ATOM   1727 C  C   . ASP A 1 258 ? -7.470  -43.690 -39.577 1.00 26.86  ? 521  ASP A C   1 
ATOM   1728 O  O   . ASP A 1 258 ? -6.836  -43.455 -40.557 1.00 30.71  ? 521  ASP A O   1 
ATOM   1729 C  CB  . ASP A 1 258 ? -9.975  -44.144 -39.834 1.00 28.02  ? 521  ASP A CB  1 
ATOM   1730 C  CG  . ASP A 1 258 ? -11.006 -45.062 -40.479 1.00 30.43  ? 521  ASP A CG  1 
ATOM   1731 O  OD1 . ASP A 1 258 ? -10.623 -46.142 -40.925 1.00 30.39  ? 521  ASP A OD1 1 
ATOM   1732 O  OD2 . ASP A 1 258 ? -12.199 -44.700 -40.456 1.00 32.50  ? 521  ASP A OD2 1 
ATOM   1733 N  N   . VAL A 1 259 ? -7.214  -43.082 -38.448 1.00 23.94  ? 522  VAL A N   1 
ATOM   1734 C  CA  . VAL A 1 259 ? -6.126  -42.081 -38.297 1.00 26.98  ? 522  VAL A CA  1 
ATOM   1735 C  C   . VAL A 1 259 ? -4.788  -42.761 -38.607 1.00 28.86  ? 522  VAL A C   1 
ATOM   1736 O  O   . VAL A 1 259 ? -3.994  -42.159 -39.326 1.00 31.94  ? 522  VAL A O   1 
ATOM   1737 C  CB  . VAL A 1 259 ? -6.129  -41.530 -36.872 1.00 26.83  ? 522  VAL A CB  1 
ATOM   1738 C  CG1 . VAL A 1 259 ? -4.836  -40.767 -36.601 1.00 27.65  ? 522  VAL A CG1 1 
ATOM   1739 C  CG2 . VAL A 1 259 ? -7.364  -40.673 -36.606 1.00 27.46  ? 522  VAL A CG2 1 
ATOM   1740 N  N   . SER A 1 260 ? -4.584  -43.997 -38.146 1.00 28.40  ? 523  SER A N   1 
ATOM   1741 C  CA  . SER A 1 260 ? -3.351  -44.796 -38.373 1.00 29.82  ? 523  SER A CA  1 
ATOM   1742 C  C   . SER A 1 260 ? -3.098  -44.986 -39.871 1.00 29.14  ? 523  SER A C   1 
ATOM   1743 O  O   . SER A 1 260 ? -1.941  -45.112 -40.231 1.00 28.98  ? 523  SER A O   1 
ATOM   1744 C  CB  . SER A 1 260 ? -3.377  -46.129 -37.681 1.00 29.18  ? 523  SER A CB  1 
ATOM   1745 O  OG  . SER A 1 260 ? -4.020  -47.111 -38.497 1.00 30.08  ? 523  SER A OG  1 
ATOM   1746 N  N   . LYS A 1 261 ? -4.118  -44.955 -40.710 1.00 29.43  ? 524  LYS A N   1 
ATOM   1747 C  CA  . LYS A 1 261 ? -4.004  -45.218 -42.170 1.00 34.66  ? 524  LYS A CA  1 
ATOM   1748 C  C   . LYS A 1 261 ? -3.398  -44.025 -42.921 1.00 35.62  ? 524  LYS A C   1 
ATOM   1749 O  O   . LYS A 1 261 ? -2.984  -44.217 -44.080 1.00 38.73  ? 524  LYS A O   1 
ATOM   1750 C  CB  . LYS A 1 261 ? -5.386  -45.495 -42.757 1.00 38.63  ? 524  LYS A CB  1 
ATOM   1751 C  CG  . LYS A 1 261 ? -5.884  -46.893 -42.487 1.00 45.99  ? 524  LYS A CG  1 
ATOM   1752 C  CD  . LYS A 1 261 ? -7.311  -47.052 -42.927 1.00 54.14  ? 524  LYS A CD  1 
ATOM   1753 C  CE  . LYS A 1 261 ? -7.819  -48.440 -42.638 1.00 58.66  ? 524  LYS A CE  1 
ATOM   1754 N  NZ  . LYS A 1 261 ? -9.290  -48.436 -42.772 1.00 70.14  ? 524  LYS A NZ  1 
ATOM   1755 N  N   . LYS A 1 262 ? -3.406  -42.846 -42.311 1.00 34.14  ? 525  LYS A N   1 
ATOM   1756 C  CA  . LYS A 1 262 ? -2.798  -41.618 -42.865 1.00 36.94  ? 525  LYS A CA  1 
ATOM   1757 C  C   . LYS A 1 262 ? -1.293  -41.810 -42.944 1.00 40.12  ? 525  LYS A C   1 
ATOM   1758 O  O   . LYS A 1 262 ? -0.729  -42.376 -42.029 1.00 36.57  ? 525  LYS A O   1 
ATOM   1759 C  CB  . LYS A 1 262 ? -3.136  -40.423 -41.982 1.00 37.52  ? 525  LYS A CB  1 
ATOM   1760 C  CG  . LYS A 1 262 ? -4.634  -40.142 -42.003 1.00 40.85  ? 525  LYS A CG  1 
ATOM   1761 C  CD  . LYS A 1 262 ? -4.997  -38.705 -42.070 1.00 42.56  ? 525  LYS A CD  1 
ATOM   1762 C  CE  . LYS A 1 262 ? -6.452  -38.491 -42.411 1.00 47.18  ? 525  LYS A CE  1 
ATOM   1763 N  NZ  . LYS A 1 262 ? -6.577  -37.440 -43.454 1.00 49.94  ? 525  LYS A NZ  1 
ATOM   1764 N  N   . GLU A 1 263 ? -0.673  -41.326 -44.004 1.00 39.27  ? 526  GLU A N   1 
ATOM   1765 C  CA  . GLU A 1 263 ? 0.809   -41.249 -44.058 1.00 38.65  ? 526  GLU A CA  1 
ATOM   1766 C  C   . GLU A 1 263 ? 1.235   -40.280 -42.949 1.00 35.60  ? 526  GLU A C   1 
ATOM   1767 O  O   . GLU A 1 263 ? 0.573   -39.256 -42.775 1.00 38.16  ? 526  GLU A O   1 
ATOM   1768 C  CB  . GLU A 1 263 ? 1.265   -40.777 -45.444 1.00 46.52  ? 526  GLU A CB  1 
ATOM   1769 C  CG  . GLU A 1 263 ? 0.940   -41.756 -46.575 1.00 51.16  ? 526  GLU A CG  1 
ATOM   1770 C  CD  . GLU A 1 263 ? 1.636   -43.111 -46.498 1.00 61.27  ? 526  GLU A CD  1 
ATOM   1771 O  OE1 . GLU A 1 263 ? 2.810   -43.155 -46.047 1.00 60.10  ? 526  GLU A OE1 1 
ATOM   1772 O  OE2 . GLU A 1 263 ? 0.998   -44.134 -46.870 1.00 64.30  ? 526  GLU A OE2 1 
ATOM   1773 N  N   . GLY A 1 264 ? 2.268   -40.613 -42.195 1.00 33.78  ? 527  GLY A N   1 
ATOM   1774 C  CA  . GLY A 1 264 ? 2.922   -39.636 -41.314 1.00 35.74  ? 527  GLY A CA  1 
ATOM   1775 C  C   . GLY A 1 264 ? 3.779   -40.292 -40.265 1.00 34.37  ? 527  GLY A C   1 
ATOM   1776 O  O   . GLY A 1 264 ? 4.241   -41.403 -40.482 1.00 36.30  ? 527  GLY A O   1 
ATOM   1777 N  N   . GLY A 1 265 ? 3.983   -39.625 -39.141 1.00 34.90  ? 528  GLY A N   1 
ATOM   1778 C  CA  . GLY A 1 265 ? 4.921   -40.103 -38.114 1.00 39.43  ? 528  GLY A CA  1 
ATOM   1779 C  C   . GLY A 1 265 ? 4.249   -41.019 -37.102 1.00 39.96  ? 528  GLY A C   1 
ATOM   1780 O  O   . GLY A 1 265 ? 3.225   -41.677 -37.455 1.00 40.95  ? 528  GLY A O   1 
ATOM   1781 N  N   . ALA A 1 266 ? 4.791   -41.063 -35.894 1.00 32.10  ? 529  ALA A N   1 
ATOM   1782 C  CA  . ALA A 1 266 ? 4.236   -41.841 -34.763 1.00 31.35  ? 529  ALA A CA  1 
ATOM   1783 C  C   . ALA A 1 266 ? 2.869   -41.270 -34.392 1.00 28.37  ? 529  ALA A C   1 
ATOM   1784 O  O   . ALA A 1 266 ? 2.535   -40.154 -34.862 1.00 26.28  ? 529  ALA A O   1 
ATOM   1785 C  CB  . ALA A 1 266 ? 5.172   -41.796 -33.585 1.00 28.69  ? 529  ALA A CB  1 
ATOM   1786 N  N   . MET A 1 267 ? 2.095   -41.982 -33.564 1.00 25.40  ? 530  MET A N   1 
ATOM   1787 C  CA  . MET A 1 267 ? 0.864   -41.434 -32.961 1.00 25.24  ? 530  MET A CA  1 
ATOM   1788 C  C   . MET A 1 267 ? 1.211   -40.907 -31.561 1.00 24.40  ? 530  MET A C   1 
ATOM   1789 O  O   . MET A 1 267 ? 1.825   -41.634 -30.761 1.00 30.86  ? 530  MET A O   1 
ATOM   1790 C  CB  . MET A 1 267 ? -0.246  -42.507 -32.934 1.00 29.37  ? 530  MET A CB  1 
ATOM   1791 C  CG  . MET A 1 267 ? -0.645  -42.940 -34.329 1.00 29.88  ? 530  MET A CG  1 
ATOM   1792 S  SD  . MET A 1 267 ? -1.980  -44.201 -34.514 1.00 34.52  ? 530  MET A SD  1 
ATOM   1793 C  CE  . MET A 1 267 ? -3.350  -43.374 -33.746 1.00 35.84  ? 530  MET A CE  1 
ATOM   1794 N  N   . TYR A 1 268 ? 0.932   -39.642 -31.303 1.00 22.21  ? 531  TYR A N   1 
ATOM   1795 C  CA  . TYR A 1 268 ? 1.243   -38.970 -30.035 1.00 22.87  ? 531  TYR A CA  1 
ATOM   1796 C  C   . TYR A 1 268 ? -0.035  -38.841 -29.225 1.00 24.74  ? 531  TYR A C   1 
ATOM   1797 O  O   . TYR A 1 268 ? -1.100  -38.413 -29.793 1.00 27.26  ? 531  TYR A O   1 
ATOM   1798 C  CB  . TYR A 1 268 ? 1.932   -37.632 -30.300 1.00 22.84  ? 531  TYR A CB  1 
ATOM   1799 C  CG  . TYR A 1 268 ? 3.253   -37.786 -30.999 1.00 25.26  ? 531  TYR A CG  1 
ATOM   1800 C  CD1 . TYR A 1 268 ? 3.316   -37.908 -32.378 1.00 23.92  ? 531  TYR A CD1 1 
ATOM   1801 C  CD2 . TYR A 1 268 ? 4.434   -37.920 -30.282 1.00 29.50  ? 531  TYR A CD2 1 
ATOM   1802 C  CE1 . TYR A 1 268 ? 4.530   -38.106 -33.020 1.00 27.69  ? 531  TYR A CE1 1 
ATOM   1803 C  CE2 . TYR A 1 268 ? 5.648   -38.124 -30.918 1.00 26.39  ? 531  TYR A CE2 1 
ATOM   1804 C  CZ  . TYR A 1 268 ? 5.699   -38.235 -32.291 1.00 29.59  ? 531  TYR A CZ  1 
ATOM   1805 O  OH  . TYR A 1 268 ? 6.873   -38.446 -32.981 1.00 27.29  ? 531  TYR A OH  1 
ATOM   1806 N  N   . ALA A 1 269 ? 0.082   -39.132 -27.930 1.00 24.64  ? 532  ALA A N   1 
ATOM   1807 C  CA  . ALA A 1 269 ? -1.042  -39.116 -26.991 1.00 25.29  ? 532  ALA A CA  1 
ATOM   1808 C  C   . ALA A 1 269 ? -0.532  -38.530 -25.700 1.00 27.14  ? 532  ALA A C   1 
ATOM   1809 O  O   . ALA A 1 269 ? -0.516  -39.243 -24.690 1.00 28.42  ? 532  ALA A O   1 
ATOM   1810 C  CB  . ALA A 1 269 ? -1.650  -40.503 -26.835 1.00 25.59  ? 532  ALA A CB  1 
ATOM   1811 N  N   . ASP A 1 270 ? -0.114  -37.272 -25.725 1.00 24.91  ? 533  ASP A N   1 
ATOM   1812 C  CA  . ASP A 1 270 ? 0.446   -36.628 -24.520 1.00 26.63  ? 533  ASP A CA  1 
ATOM   1813 C  C   . ASP A 1 270 ? -0.713  -36.175 -23.649 1.00 31.08  ? 533  ASP A C   1 
ATOM   1814 O  O   . ASP A 1 270 ? -1.545  -35.453 -24.174 1.00 29.33  ? 533  ASP A O   1 
ATOM   1815 C  CB  . ASP A 1 270 ? 1.343   -35.440 -24.911 1.00 28.69  ? 533  ASP A CB  1 
ATOM   1816 C  CG  . ASP A 1 270 ? 2.640   -35.842 -25.597 1.00 30.22  ? 533  ASP A CG  1 
ATOM   1817 O  OD1 . ASP A 1 270 ? 3.019   -37.042 -25.485 1.00 30.85  ? 533  ASP A OD1 1 
ATOM   1818 O  OD2 . ASP A 1 270 ? 3.231   -34.985 -26.297 1.00 30.77  ? 533  ASP A OD2 1 
ATOM   1819 N  N   . ASP A 1 271 ? -0.726  -36.530 -22.361 1.00 32.31  ? 534  ASP A N   1 
ATOM   1820 C  CA  . ASP A 1 271 ? -1.686  -35.995 -21.358 1.00 35.33  ? 534  ASP A CA  1 
ATOM   1821 C  C   . ASP A 1 271 ? -1.182  -34.650 -20.838 1.00 34.86  ? 534  ASP A C   1 
ATOM   1822 O  O   . ASP A 1 271 ? 0.046   -34.471 -20.710 1.00 32.77  ? 534  ASP A O   1 
ATOM   1823 C  CB  . ASP A 1 271 ? -1.930  -36.969 -20.200 1.00 40.24  ? 534  ASP A CB  1 
ATOM   1824 C  CG  . ASP A 1 271 ? -2.946  -38.043 -20.556 1.00 49.94  ? 534  ASP A CG  1 
ATOM   1825 O  OD1 . ASP A 1 271 ? -3.646  -37.887 -21.605 1.00 47.18  ? 534  ASP A OD1 1 
ATOM   1826 O  OD2 . ASP A 1 271 ? -3.054  -39.024 -19.806 1.00 50.85  ? 534  ASP A OD2 1 
ATOM   1827 N  N   . THR A 1 272 ? -2.094  -33.711 -20.590 1.00 28.87  ? 535  THR A N   1 
ATOM   1828 C  CA  . THR A 1 272 ? -1.776  -32.408 -19.966 1.00 27.07  ? 535  THR A CA  1 
ATOM   1829 C  C   . THR A 1 272 ? -1.842  -32.618 -18.468 1.00 30.62  ? 535  THR A C   1 
ATOM   1830 O  O   . THR A 1 272 ? -2.740  -33.315 -18.046 1.00 31.74  ? 535  THR A O   1 
ATOM   1831 C  CB  . THR A 1 272 ? -2.697  -31.289 -20.438 1.00 31.26  ? 535  THR A CB  1 
ATOM   1832 O  OG1 . THR A 1 272 ? -2.498  -31.122 -21.839 1.00 30.03  ? 535  THR A OG1 1 
ATOM   1833 C  CG2 . THR A 1 272 ? -2.406  -29.956 -19.797 1.00 32.65  ? 535  THR A CG2 1 
ATOM   1834 N  N   . ALA A 1 273 ? -0.928  -32.018 -17.709 1.00 34.29  ? 536  ALA A N   1 
ATOM   1835 C  CA  . ALA A 1 273 ? -1.006  -31.979 -16.228 1.00 39.14  ? 536  ALA A CA  1 
ATOM   1836 C  C   . ALA A 1 273 ? -2.079  -30.943 -15.830 1.00 37.37  ? 536  ALA A C   1 
ATOM   1837 O  O   . ALA A 1 273 ? -1.899  -29.774 -16.152 1.00 40.65  ? 536  ALA A O   1 
ATOM   1838 C  CB  . ALA A 1 273 ? 0.373   -31.686 -15.680 1.00 37.39  ? 536  ALA A CB  1 
ATOM   1839 N  N   . GLY A 1 274 ? -3.214  -31.400 -15.302 1.00 38.24  ? 537  GLY A N   1 
ATOM   1840 C  CA  . GLY A 1 274 ? -4.327  -30.578 -14.774 1.00 37.32  ? 537  GLY A CA  1 
ATOM   1841 C  C   . GLY A 1 274 ? -4.862  -29.579 -15.792 1.00 37.98  ? 537  GLY A C   1 
ATOM   1842 O  O   . GLY A 1 274 ? -4.841  -28.352 -15.525 1.00 34.81  ? 537  GLY A O   1 
ATOM   1843 N  N   . TRP A 1 275 ? -5.394  -30.084 -16.903 1.00 34.21  ? 538  TRP A N   1 
ATOM   1844 C  CA  . TRP A 1 275 ? -5.879  -29.257 -18.036 1.00 32.86  ? 538  TRP A CA  1 
ATOM   1845 C  C   . TRP A 1 275 ? -6.728  -28.068 -17.548 1.00 30.13  ? 538  TRP A C   1 
ATOM   1846 O  O   . TRP A 1 275 ? -6.427  -26.935 -17.980 1.00 29.73  ? 538  TRP A O   1 
ATOM   1847 C  CB  . TRP A 1 275 ? -6.624  -30.106 -19.062 1.00 29.20  ? 538  TRP A CB  1 
ATOM   1848 C  CG  . TRP A 1 275 ? -7.220  -29.278 -20.154 1.00 29.84  ? 538  TRP A CG  1 
ATOM   1849 C  CD1 . TRP A 1 275 ? -8.424  -28.638 -20.094 1.00 31.03  ? 538  TRP A CD1 1 
ATOM   1850 C  CD2 . TRP A 1 275 ? -6.679  -28.992 -21.452 1.00 26.51  ? 538  TRP A CD2 1 
ATOM   1851 N  NE1 . TRP A 1 275 ? -8.673  -27.996 -21.270 1.00 31.65  ? 538  TRP A NE1 1 
ATOM   1852 C  CE2 . TRP A 1 275 ? -7.613  -28.165 -22.110 1.00 29.66  ? 538  TRP A CE2 1 
ATOM   1853 C  CE3 . TRP A 1 275 ? -5.517  -29.341 -22.137 1.00 29.79  ? 538  TRP A CE3 1 
ATOM   1854 C  CZ2 . TRP A 1 275 ? -7.440  -27.712 -23.411 1.00 29.58  ? 538  TRP A CZ2 1 
ATOM   1855 C  CZ3 . TRP A 1 275 ? -5.323  -28.856 -23.414 1.00 28.60  ? 538  TRP A CZ3 1 
ATOM   1856 C  CH2 . TRP A 1 275 ? -6.277  -28.066 -24.047 1.00 34.40  ? 538  TRP A CH2 1 
ATOM   1857 N  N   . ASP A 1 276 ? -7.733  -28.298 -16.723 1.00 31.74  ? 539  ASP A N   1 
ATOM   1858 C  CA  . ASP A 1 276 ? -8.728  -27.255 -16.310 1.00 36.54  ? 539  ASP A CA  1 
ATOM   1859 C  C   . ASP A 1 276 ? -7.996  -26.113 -15.578 1.00 41.01  ? 539  ASP A C   1 
ATOM   1860 O  O   . ASP A 1 276 ? -8.369  -24.925 -15.796 1.00 35.49  ? 539  ASP A O   1 
ATOM   1861 C  CB  . ASP A 1 276 ? -9.866  -27.872 -15.506 1.00 36.59  ? 539  ASP A CB  1 
ATOM   1862 C  CG  . ASP A 1 276 ? -10.862 -28.664 -16.358 1.00 39.93  ? 539  ASP A CG  1 
ATOM   1863 O  OD1 . ASP A 1 276 ? -10.755 -28.633 -17.587 1.00 42.96  ? 539  ASP A OD1 1 
ATOM   1864 O  OD2 . ASP A 1 276 ? -11.741 -29.300 -15.792 1.00 45.78  ? 539  ASP A OD2 1 
ATOM   1865 N  N   . THR A 1 277 ? -6.922  -26.418 -14.845 1.00 38.26  ? 540  THR A N   1 
ATOM   1866 C  CA  . THR A 1 277 ? -6.131  -25.387 -14.121 1.00 38.95  ? 540  THR A CA  1 
ATOM   1867 C  C   . THR A 1 277 ? -5.230  -24.600 -15.079 1.00 40.94  ? 540  THR A C   1 
ATOM   1868 O  O   . THR A 1 277 ? -4.762  -23.572 -14.642 1.00 43.92  ? 540  THR A O   1 
ATOM   1869 C  CB  . THR A 1 277 ? -5.344  -25.988 -12.947 1.00 40.42  ? 540  THR A CB  1 
ATOM   1870 O  OG1 . THR A 1 277 ? -4.286  -26.803 -13.437 1.00 44.52  ? 540  THR A OG1 1 
ATOM   1871 C  CG2 . THR A 1 277 ? -6.216  -26.805 -12.030 1.00 42.67  ? 540  THR A CG2 1 
ATOM   1872 N  N   . ARG A 1 278 ? -4.996  -25.035 -16.328 1.00 36.30  ? 541  ARG A N   1 
ATOM   1873 C  CA  . ARG A 1 278 ? -4.085  -24.361 -17.290 1.00 34.74  ? 541  ARG A CA  1 
ATOM   1874 C  C   . ARG A 1 278 ? -4.838  -23.569 -18.350 1.00 33.19  ? 541  ARG A C   1 
ATOM   1875 O  O   . ARG A 1 278 ? -4.194  -23.227 -19.327 1.00 33.34  ? 541  ARG A O   1 
ATOM   1876 C  CB  . ARG A 1 278 ? -3.277  -25.372 -18.104 1.00 38.47  ? 541  ARG A CB  1 
ATOM   1877 C  CG  . ARG A 1 278 ? -2.633  -26.464 -17.275 1.00 43.97  ? 541  ARG A CG  1 
ATOM   1878 C  CD  . ARG A 1 278 ? -1.493  -25.922 -16.461 1.00 48.42  ? 541  ARG A CD  1 
ATOM   1879 N  NE  . ARG A 1 278 ? -0.818  -27.026 -15.773 1.00 57.96  ? 541  ARG A NE  1 
ATOM   1880 C  CZ  . ARG A 1 278 ? 0.466   -27.034 -15.437 1.00 57.73  ? 541  ARG A CZ  1 
ATOM   1881 N  NH1 . ARG A 1 278 ? 1.250   -26.025 -15.780 1.00 60.80  ? 541  ARG A NH1 1 
ATOM   1882 N  NH2 . ARG A 1 278 ? 0.963   -28.053 -14.762 1.00 68.67  ? 541  ARG A NH2 1 
ATOM   1883 N  N   . ILE A 1 279 ? -6.166  -23.472 -18.269 1.00 31.09  ? 542  ILE A N   1 
ATOM   1884 C  CA  . ILE A 1 279 ? -6.990  -22.616 -19.162 1.00 33.65  ? 542  ILE A CA  1 
ATOM   1885 C  C   . ILE A 1 279 ? -6.714  -21.153 -18.788 1.00 33.34  ? 542  ILE A C   1 
ATOM   1886 O  O   . ILE A 1 279 ? -6.979  -20.784 -17.657 1.00 37.88  ? 542  ILE A O   1 
ATOM   1887 C  CB  . ILE A 1 279 ? -8.470  -23.021 -19.055 1.00 34.08  ? 542  ILE A CB  1 
ATOM   1888 C  CG1 . ILE A 1 279 ? -8.674  -24.367 -19.754 1.00 35.13  ? 542  ILE A CG1 1 
ATOM   1889 C  CG2 . ILE A 1 279 ? -9.429  -21.962 -19.612 1.00 34.97  ? 542  ILE A CG2 1 
ATOM   1890 C  CD1 . ILE A 1 279 ? -8.491  -24.281 -21.254 1.00 35.48  ? 542  ILE A CD1 1 
ATOM   1891 N  N   . THR A 1 280 ? -6.139  -20.392 -19.707 1.00 38.42  ? 543  THR A N   1 
ATOM   1892 C  CA  . THR A 1 280 ? -5.703  -18.989 -19.484 1.00 40.61  ? 543  THR A CA  1 
ATOM   1893 C  C   . THR A 1 280 ? -6.873  -18.050 -19.761 1.00 41.99  ? 543  THR A C   1 
ATOM   1894 O  O   . THR A 1 280 ? -7.856  -18.485 -20.399 1.00 37.38  ? 543  THR A O   1 
ATOM   1895 C  CB  . THR A 1 280 ? -4.514  -18.668 -20.374 1.00 36.66  ? 543  THR A CB  1 
ATOM   1896 O  OG1 . THR A 1 280 ? -4.936  -18.776 -21.737 1.00 37.27  ? 543  THR A OG1 1 
ATOM   1897 C  CG2 . THR A 1 280 ? -3.367  -19.605 -20.089 1.00 42.48  ? 543  THR A CG2 1 
ATOM   1898 N  N   . LEU A 1 281 ? -6.794  -16.803 -19.312 1.00 42.19  ? 544  LEU A N   1 
ATOM   1899 C  CA  . LEU A 1 281 ? -7.829  -15.802 -19.686 1.00 43.84  ? 544  LEU A CA  1 
ATOM   1900 C  C   . LEU A 1 281 ? -7.818  -15.652 -21.217 1.00 36.82  ? 544  LEU A C   1 
ATOM   1901 O  O   . LEU A 1 281 ? -8.877  -15.467 -21.779 1.00 37.06  ? 544  LEU A O   1 
ATOM   1902 C  CB  . LEU A 1 281 ? -7.547  -14.471 -18.968 1.00 54.27  ? 544  LEU A CB  1 
ATOM   1903 C  CG  . LEU A 1 281 ? -8.486  -13.307 -19.313 1.00 59.99  ? 544  LEU A CG  1 
ATOM   1904 C  CD1 . LEU A 1 281 ? -9.974  -13.711 -19.321 1.00 54.83  ? 544  LEU A CD1 1 
ATOM   1905 C  CD2 . LEU A 1 281 ? -8.249  -12.147 -18.352 1.00 61.54  ? 544  LEU A CD2 1 
ATOM   1906 N  N   . GLU A 1 282 ? -6.675  -15.838 -21.895 1.00 38.46  ? 545  GLU A N   1 
ATOM   1907 C  CA  . GLU A 1 282 ? -6.606  -15.755 -23.387 1.00 39.41  ? 545  GLU A CA  1 
ATOM   1908 C  C   . GLU A 1 282 ? -7.433  -16.889 -24.032 1.00 39.87  ? 545  GLU A C   1 
ATOM   1909 O  O   . GLU A 1 282 ? -8.197  -16.646 -25.024 1.00 34.15  ? 545  GLU A O   1 
ATOM   1910 C  CB  . GLU A 1 282 ? -5.142  -15.786 -23.809 1.00 46.55  ? 545  GLU A CB  1 
ATOM   1911 C  CG  . GLU A 1 282 ? -4.922  -15.192 -25.176 1.00 59.33  ? 545  GLU A CG  1 
ATOM   1912 C  CD  . GLU A 1 282 ? -5.207  -13.700 -25.252 1.00 57.71  ? 545  GLU A CD  1 
ATOM   1913 O  OE1 . GLU A 1 282 ? -5.149  -13.029 -24.200 1.00 55.65  ? 545  GLU A OE1 1 
ATOM   1914 O  OE2 . GLU A 1 282 ? -5.519  -13.238 -26.357 1.00 60.85  ? 545  GLU A OE2 1 
ATOM   1915 N  N   . ASP A 1 283 ? -7.296  -18.112 -23.516 1.00 35.17  ? 546  ASP A N   1 
ATOM   1916 C  CA  . ASP A 1 283 ? -8.157  -19.271 -23.911 1.00 32.43  ? 546  ASP A CA  1 
ATOM   1917 C  C   . ASP A 1 283 ? -9.658  -18.903 -23.753 1.00 33.65  ? 546  ASP A C   1 
ATOM   1918 O  O   . ASP A 1 283 ? -10.404 -19.073 -24.728 1.00 35.64  ? 546  ASP A O   1 
ATOM   1919 C  CB  . ASP A 1 283 ? -7.826  -20.498 -23.052 1.00 29.97  ? 546  ASP A CB  1 
ATOM   1920 C  CG  . ASP A 1 283 ? -6.455  -21.136 -23.311 1.00 29.08  ? 546  ASP A CG  1 
ATOM   1921 O  OD1 . ASP A 1 283 ? -5.952  -21.044 -24.432 1.00 29.36  ? 546  ASP A OD1 1 
ATOM   1922 O  OD2 . ASP A 1 283 ? -5.961  -21.792 -22.389 1.00 29.31  ? 546  ASP A OD2 1 
ATOM   1923 N  N   . LEU A 1 284 ? -10.092 -18.382 -22.595 1.00 33.65  ? 547  LEU A N   1 
ATOM   1924 C  CA  . LEU A 1 284 ? -11.523 -17.996 -22.342 1.00 34.52  ? 547  LEU A CA  1 
ATOM   1925 C  C   . LEU A 1 284 ? -12.029 -16.941 -23.351 1.00 33.51  ? 547  LEU A C   1 
ATOM   1926 O  O   . LEU A 1 284 ? -13.195 -17.058 -23.773 1.00 37.11  ? 547  LEU A O   1 
ATOM   1927 C  CB  . LEU A 1 284 ? -11.665 -17.520 -20.896 1.00 35.58  ? 547  LEU A CB  1 
ATOM   1928 C  CG  . LEU A 1 284 ? -11.388 -18.573 -19.822 1.00 37.82  ? 547  LEU A CG  1 
ATOM   1929 C  CD1 . LEU A 1 284 ? -11.298 -17.937 -18.449 1.00 45.98  ? 547  LEU A CD1 1 
ATOM   1930 C  CD2 . LEU A 1 284 ? -12.443 -19.669 -19.789 1.00 36.16  ? 547  LEU A CD2 1 
ATOM   1931 N  N   . LYS A 1 285 ? -11.169 -16.008 -23.797 1.00 38.83  ? 548  LYS A N   1 
ATOM   1932 C  CA  . LYS A 1 285 ? -11.483 -14.949 -24.801 1.00 38.29  ? 548  LYS A CA  1 
ATOM   1933 C  C   . LYS A 1 285 ? -11.585 -15.553 -26.200 1.00 37.96  ? 548  LYS A C   1 
ATOM   1934 O  O   . LYS A 1 285 ? -12.467 -15.138 -26.980 1.00 33.23  ? 548  LYS A O   1 
ATOM   1935 C  CB  . LYS A 1 285 ? -10.469 -13.803 -24.697 1.00 41.89  ? 548  LYS A CB  1 
ATOM   1936 C  CG  . LYS A 1 285 ? -10.752 -12.917 -23.497 1.00 48.83  ? 548  LYS A CG  1 
ATOM   1937 C  CD  . LYS A 1 285 ? -9.814  -11.751 -23.330 1.00 62.88  ? 548  LYS A CD  1 
ATOM   1938 C  CE  . LYS A 1 285 ? -10.345 -10.727 -22.342 1.00 68.23  ? 548  LYS A CE  1 
ATOM   1939 N  NZ  . LYS A 1 285 ? -9.487  -9.518  -22.301 1.00 82.29  ? 548  LYS A NZ  1 
ATOM   1940 N  N   . ASN A 1 286 ? -10.747 -16.517 -26.545 1.00 31.17  ? 549  ASN A N   1 
ATOM   1941 C  CA  . ASN A 1 286 ? -10.875 -17.195 -27.857 1.00 31.22  ? 549  ASN A CA  1 
ATOM   1942 C  C   . ASN A 1 286 ? -12.148 -18.075 -27.880 1.00 28.36  ? 549  ASN A C   1 
ATOM   1943 O  O   . ASN A 1 286 ? -12.749 -18.182 -28.936 1.00 32.11  ? 549  ASN A O   1 
ATOM   1944 C  CB  . ASN A 1 286 ? -9.591  -17.971 -28.144 1.00 35.28  ? 549  ASN A CB  1 
ATOM   1945 C  CG  . ASN A 1 286 ? -8.416  -17.037 -28.378 1.00 41.70  ? 549  ASN A CG  1 
ATOM   1946 O  OD1 . ASN A 1 286 ? -8.564  -15.953 -28.949 1.00 35.35  ? 549  ASN A OD1 1 
ATOM   1947 N  ND2 . ASN A 1 286 ? -7.231  -17.468 -27.996 1.00 39.04  ? 549  ASN A ND2 1 
ATOM   1948 N  N   . GLU A 1 287 ? -12.501 -18.727 -26.779 1.00 28.55  ? 550  GLU A N   1 
ATOM   1949 C  CA  . GLU A 1 287 ? -13.734 -19.562 -26.656 1.00 30.22  ? 550  GLU A CA  1 
ATOM   1950 C  C   . GLU A 1 287 ? -14.993 -18.665 -26.795 1.00 31.28  ? 550  GLU A C   1 
ATOM   1951 O  O   . GLU A 1 287 ? -15.903 -19.010 -27.598 1.00 31.66  ? 550  GLU A O   1 
ATOM   1952 C  CB  . GLU A 1 287 ? -13.685 -20.302 -25.324 1.00 30.30  ? 550  GLU A CB  1 
ATOM   1953 C  CG  . GLU A 1 287 ? -12.637 -21.409 -25.321 1.00 31.44  ? 550  GLU A CG  1 
ATOM   1954 C  CD  . GLU A 1 287 ? -12.399 -21.989 -23.947 1.00 34.39  ? 550  GLU A CD  1 
ATOM   1955 O  OE1 . GLU A 1 287 ? -13.150 -21.623 -23.010 1.00 37.42  ? 550  GLU A OE1 1 
ATOM   1956 O  OE2 . GLU A 1 287 ? -11.460 -22.818 -23.798 1.00 38.28  ? 550  GLU A OE2 1 
ATOM   1957 N  N   . GLU A 1 288 ? -14.964 -17.494 -26.165 1.00 33.40  ? 551  GLU A N   1 
ATOM   1958 C  CA  . GLU A 1 288 ? -16.022 -16.437 -26.259 1.00 34.56  ? 551  GLU A CA  1 
ATOM   1959 C  C   . GLU A 1 288 ? -16.331 -16.034 -27.713 1.00 35.30  ? 551  GLU A C   1 
ATOM   1960 O  O   . GLU A 1 288 ? -17.500 -15.661 -27.994 1.00 36.78  ? 551  GLU A O   1 
ATOM   1961 C  CB  . GLU A 1 288 ? -15.598 -15.248 -25.396 1.00 39.69  ? 551  GLU A CB  1 
ATOM   1962 C  CG  . GLU A 1 288 ? -16.734 -14.309 -24.993 1.00 44.92  ? 551  GLU A CG  1 
ATOM   1963 C  CD  . GLU A 1 288 ? -17.068 -13.177 -25.952 1.00 52.95  ? 551  GLU A CD  1 
ATOM   1964 O  OE1 . GLU A 1 288 ? -16.248 -12.907 -26.846 1.00 49.40  ? 551  GLU A OE1 1 
ATOM   1965 O  OE2 . GLU A 1 288 ? -18.157 -12.560 -25.792 1.00 57.15  ? 551  GLU A OE2 1 
ATOM   1966 N  N   . MET A 1 289 ? -15.392 -16.165 -28.644 1.00 33.90  ? 552  MET A N   1 
ATOM   1967 C  CA  . MET A 1 289 ? -15.614 -15.781 -30.057 1.00 35.08  ? 552  MET A CA  1 
ATOM   1968 C  C   . MET A 1 289 ? -16.716 -16.617 -30.697 1.00 37.47  ? 552  MET A C   1 
ATOM   1969 O  O   . MET A 1 289 ? -17.139 -16.253 -31.826 1.00 38.76  ? 552  MET A O   1 
ATOM   1970 C  CB  . MET A 1 289 ? -14.329 -15.856 -30.896 1.00 37.43  ? 552  MET A CB  1 
ATOM   1971 C  CG  . MET A 1 289 ? -13.293 -14.822 -30.478 1.00 42.48  ? 552  MET A CG  1 
ATOM   1972 S  SD  . MET A 1 289 ? -11.975 -14.494 -31.716 1.00 50.12  ? 552  MET A SD  1 
ATOM   1973 C  CE  . MET A 1 289 ? -11.473 -16.148 -32.165 1.00 45.02  ? 552  MET A CE  1 
ATOM   1974 N  N   . VAL A 1 290 ? -17.200 -17.688 -30.063 1.00 34.32  ? 553  VAL A N   1 
ATOM   1975 C  CA  . VAL A 1 290 ? -18.390 -18.384 -30.633 1.00 32.70  ? 553  VAL A CA  1 
ATOM   1976 C  C   . VAL A 1 290 ? -19.564 -17.385 -30.701 1.00 28.80  ? 553  VAL A C   1 
ATOM   1977 O  O   . VAL A 1 290 ? -20.356 -17.502 -31.642 1.00 38.31  ? 553  VAL A O   1 
ATOM   1978 C  CB  . VAL A 1 290 ? -18.785 -19.668 -29.884 1.00 28.66  ? 553  VAL A CB  1 
ATOM   1979 C  CG1 . VAL A 1 290 ? -19.204 -19.424 -28.450 1.00 29.39  ? 553  VAL A CG1 1 
ATOM   1980 C  CG2 . VAL A 1 290 ? -19.855 -20.431 -30.640 1.00 29.15  ? 553  VAL A CG2 1 
ATOM   1981 N  N   . THR A 1 291 ? -19.650 -16.429 -29.782 1.00 31.91  ? 554  THR A N   1 
ATOM   1982 C  CA  . THR A 1 291 ? -20.746 -15.401 -29.791 1.00 35.63  ? 554  THR A CA  1 
ATOM   1983 C  C   . THR A 1 291 ? -20.733 -14.559 -31.082 1.00 38.35  ? 554  THR A C   1 
ATOM   1984 O  O   . THR A 1 291 ? -21.836 -13.996 -31.417 1.00 41.82  ? 554  THR A O   1 
ATOM   1985 C  CB  . THR A 1 291 ? -20.677 -14.449 -28.602 1.00 32.99  ? 554  THR A CB  1 
ATOM   1986 O  OG1 . THR A 1 291 ? -19.425 -13.770 -28.678 1.00 33.94  ? 554  THR A OG1 1 
ATOM   1987 C  CG2 . THR A 1 291 ? -20.834 -15.135 -27.271 1.00 32.49  ? 554  THR A CG2 1 
ATOM   1988 N  N   . ASN A 1 292 ? -19.593 -14.464 -31.788 1.00 38.97  ? 555  ASN A N   1 
ATOM   1989 C  CA  . ASN A 1 292 ? -19.489 -13.743 -33.095 1.00 41.39  ? 555  ASN A CA  1 
ATOM   1990 C  C   . ASN A 1 292 ? -20.401 -14.366 -34.154 1.00 46.64  ? 555  ASN A C   1 
ATOM   1991 O  O   . ASN A 1 292 ? -20.591 -13.724 -35.223 1.00 46.38  ? 555  ASN A O   1 
ATOM   1992 C  CB  . ASN A 1 292 ? -18.095 -13.767 -33.725 1.00 39.06  ? 555  ASN A CB  1 
ATOM   1993 C  CG  . ASN A 1 292 ? -17.107 -12.975 -32.915 1.00 39.16  ? 555  ASN A CG  1 
ATOM   1994 O  OD1 . ASN A 1 292 ? -17.497 -12.241 -32.014 1.00 45.32  ? 555  ASN A OD1 1 
ATOM   1995 N  ND2 . ASN A 1 292 ? -15.834 -13.172 -33.183 1.00 41.67  ? 555  ASN A ND2 1 
ATOM   1996 N  N   . HIS A 1 293 ? -20.854 -15.602 -33.943 1.00 39.11  ? 556  HIS A N   1 
ATOM   1997 C  CA  . HIS A 1 293 ? -21.681 -16.366 -34.908 1.00 41.21  ? 556  HIS A CA  1 
ATOM   1998 C  C   . HIS A 1 293 ? -23.153 -16.285 -34.506 1.00 36.49  ? 556  HIS A C   1 
ATOM   1999 O  O   . HIS A 1 293 ? -23.981 -16.947 -35.120 1.00 36.44  ? 556  HIS A O   1 
ATOM   2000 C  CB  . HIS A 1 293 ? -21.126 -17.795 -35.013 1.00 41.51  ? 556  HIS A CB  1 
ATOM   2001 C  CG  . HIS A 1 293 ? -19.734 -17.786 -35.545 1.00 44.40  ? 556  HIS A CG  1 
ATOM   2002 N  ND1 . HIS A 1 293 ? -19.471 -17.912 -36.896 1.00 44.02  ? 556  HIS A ND1 1 
ATOM   2003 C  CD2 . HIS A 1 293 ? -18.537 -17.583 -34.937 1.00 44.70  ? 556  HIS A CD2 1 
ATOM   2004 C  CE1 . HIS A 1 293 ? -18.173 -17.839 -37.095 1.00 42.81  ? 556  HIS A CE1 1 
ATOM   2005 N  NE2 . HIS A 1 293 ? -17.578 -17.617 -35.917 1.00 43.87  ? 556  HIS A NE2 1 
ATOM   2006 N  N   . MET A 1 294 ? -23.439 -15.556 -33.443 1.00 35.06  ? 557  MET A N   1 
ATOM   2007 C  CA  . MET A 1 294 ? -24.787 -15.511 -32.842 1.00 35.36  ? 557  MET A CA  1 
ATOM   2008 C  C   . MET A 1 294 ? -25.460 -14.185 -33.216 1.00 41.27  ? 557  MET A C   1 
ATOM   2009 O  O   . MET A 1 294 ? -24.813 -13.366 -33.856 1.00 40.70  ? 557  MET A O   1 
ATOM   2010 C  CB  . MET A 1 294 ? -24.694 -15.602 -31.330 1.00 38.64  ? 557  MET A CB  1 
ATOM   2011 C  CG  . MET A 1 294 ? -24.181 -16.977 -30.843 1.00 36.27  ? 557  MET A CG  1 
ATOM   2012 S  SD  . MET A 1 294 ? -24.167 -16.945 -29.068 1.00 35.72  ? 557  MET A SD  1 
ATOM   2013 C  CE  . MET A 1 294 ? -23.151 -18.400 -28.760 1.00 40.28  ? 557  MET A CE  1 
ATOM   2014 N  N   . GLU A 1 295 ? -26.708 -14.004 -32.815 1.00 42.94  ? 558  GLU A N   1 
ATOM   2015 C  CA  . GLU A 1 295 ? -27.478 -12.777 -33.132 1.00 47.71  ? 558  GLU A CA  1 
ATOM   2016 C  C   . GLU A 1 295 ? -28.531 -12.492 -32.075 1.00 49.62  ? 558  GLU A C   1 
ATOM   2017 O  O   . GLU A 1 295 ? -28.954 -13.427 -31.353 1.00 44.89  ? 558  GLU A O   1 
ATOM   2018 C  CB  . GLU A 1 295 ? -28.152 -12.934 -34.480 1.00 46.88  ? 558  GLU A CB  1 
ATOM   2019 C  CG  . GLU A 1 295 ? -29.318 -13.880 -34.486 1.00 46.81  ? 558  GLU A CG  1 
ATOM   2020 C  CD  . GLU A 1 295 ? -29.888 -14.030 -35.885 1.00 59.21  ? 558  GLU A CD  1 
ATOM   2021 O  OE1 . GLU A 1 295 ? -29.095 -14.045 -36.882 1.00 65.65  ? 558  GLU A OE1 1 
ATOM   2022 O  OE2 . GLU A 1 295 ? -31.118 -14.096 -35.984 1.00 60.56  ? 558  GLU A OE2 1 
ATOM   2023 N  N   . GLY A 1 296 ? -28.964 -11.231 -32.058 1.00 56.68  ? 559  GLY A N   1 
ATOM   2024 C  CA  . GLY A 1 296 ? -30.066 -10.740 -31.223 1.00 50.14  ? 559  GLY A CA  1 
ATOM   2025 C  C   . GLY A 1 296 ? -29.795 -11.015 -29.763 1.00 50.34  ? 559  GLY A C   1 
ATOM   2026 O  O   . GLY A 1 296 ? -28.625 -10.844 -29.305 1.00 47.45  ? 559  GLY A O   1 
ATOM   2027 N  N   . GLU A 1 297 ? -30.835 -11.514 -29.107 1.00 45.98  ? 560  GLU A N   1 
ATOM   2028 C  CA  . GLU A 1 297 ? -30.877 -11.844 -27.671 1.00 50.99  ? 560  GLU A CA  1 
ATOM   2029 C  C   . GLU A 1 297 ? -29.796 -12.892 -27.342 1.00 53.41  ? 560  GLU A C   1 
ATOM   2030 O  O   . GLU A 1 297 ? -29.040 -12.687 -26.378 1.00 49.23  ? 560  GLU A O   1 
ATOM   2031 C  CB  . GLU A 1 297 ? -32.266 -12.385 -27.365 1.00 52.77  ? 560  GLU A CB  1 
ATOM   2032 C  CG  . GLU A 1 297 ? -32.563 -12.446 -25.885 1.00 61.72  ? 560  GLU A CG  1 
ATOM   2033 C  CD  . GLU A 1 297 ? -34.040 -12.400 -25.560 1.00 64.71  ? 560  GLU A CD  1 
ATOM   2034 O  OE1 . GLU A 1 297 ? -34.721 -13.398 -25.841 1.00 69.61  ? 560  GLU A OE1 1 
ATOM   2035 O  OE2 . GLU A 1 297 ? -34.495 -11.365 -25.023 1.00 77.21  ? 560  GLU A OE2 1 
ATOM   2036 N  N   . HIS A 1 298 ? -29.750 -13.981 -28.108 1.00 47.89  ? 561  HIS A N   1 
ATOM   2037 C  CA  . HIS A 1 298 ? -28.872 -15.147 -27.838 1.00 47.65  ? 561  HIS A CA  1 
ATOM   2038 C  C   . HIS A 1 298 ? -27.450 -14.608 -27.697 1.00 43.52  ? 561  HIS A C   1 
ATOM   2039 O  O   . HIS A 1 298 ? -26.841 -14.822 -26.632 1.00 49.03  ? 561  HIS A O   1 
ATOM   2040 C  CB  . HIS A 1 298 ? -29.047 -16.217 -28.911 1.00 44.33  ? 561  HIS A CB  1 
ATOM   2041 C  CG  . HIS A 1 298 ? -28.164 -17.407 -28.698 1.00 43.39  ? 561  HIS A CG  1 
ATOM   2042 N  ND1 . HIS A 1 298 ? -27.674 -18.159 -29.752 1.00 41.19  ? 561  HIS A ND1 1 
ATOM   2043 C  CD2 . HIS A 1 298 ? -27.696 -17.969 -27.561 1.00 40.01  ? 561  HIS A CD2 1 
ATOM   2044 C  CE1 . HIS A 1 298 ? -26.939 -19.146 -29.264 1.00 43.36  ? 561  HIS A CE1 1 
ATOM   2045 N  NE2 . HIS A 1 298 ? -26.948 -19.057 -27.913 1.00 41.03  ? 561  HIS A NE2 1 
ATOM   2046 N  N   . LYS A 1 299 ? -27.014 -13.805 -28.664 1.00 37.87  ? 562  LYS A N   1 
ATOM   2047 C  CA  . LYS A 1 299 ? -25.687 -13.172 -28.643 1.00 41.79  ? 562  LYS A CA  1 
ATOM   2048 C  C   . LYS A 1 299 ? -25.481 -12.497 -27.287 1.00 52.81  ? 562  LYS A C   1 
ATOM   2049 O  O   . LYS A 1 299 ? -24.395 -12.683 -26.701 1.00 48.08  ? 562  LYS A O   1 
ATOM   2050 C  CB  . LYS A 1 299 ? -25.511 -12.210 -29.804 1.00 41.97  ? 562  LYS A CB  1 
ATOM   2051 C  CG  . LYS A 1 299 ? -24.137 -11.578 -29.833 1.00 42.45  ? 562  LYS A CG  1 
ATOM   2052 C  CD  . LYS A 1 299 ? -23.983 -10.603 -30.950 1.00 45.75  ? 562  LYS A CD  1 
ATOM   2053 C  CE  . LYS A 1 299 ? -22.593 -10.036 -31.063 1.00 48.25  ? 562  LYS A CE  1 
ATOM   2054 N  NZ  . LYS A 1 299 ? -21.800 -10.811 -32.040 1.00 51.86  ? 562  LYS A NZ  1 
ATOM   2055 N  N   . LYS A 1 300 ? -26.476 -11.759 -26.782 1.00 51.34  ? 563  LYS A N   1 
ATOM   2056 C  CA  . LYS A 1 300 ? -26.303 -10.976 -25.526 1.00 50.91  ? 563  LYS A CA  1 
ATOM   2057 C  C   . LYS A 1 300 ? -26.252 -11.936 -24.344 1.00 36.26  ? 563  LYS A C   1 
ATOM   2058 O  O   . LYS A 1 300 ? -25.442 -11.710 -23.483 1.00 43.11  ? 563  LYS A O   1 
ATOM   2059 C  CB  . LYS A 1 300 ? -27.418 -9.941  -25.281 1.00 58.69  ? 563  LYS A CB  1 
ATOM   2060 C  CG  . LYS A 1 300 ? -27.498 -8.813  -26.303 1.00 63.63  ? 563  LYS A CG  1 
ATOM   2061 C  CD  . LYS A 1 300 ? -26.212 -8.033  -26.499 1.00 66.58  ? 563  LYS A CD  1 
ATOM   2062 C  CE  . LYS A 1 300 ? -26.058 -7.473  -27.901 1.00 74.69  ? 563  LYS A CE  1 
ATOM   2063 N  NZ  . LYS A 1 300 ? -25.207 -6.257  -27.919 1.00 79.72  ? 563  LYS A NZ  1 
ATOM   2064 N  N   . LEU A 1 301 ? -27.123 -12.936 -24.311 1.00 41.00  ? 564  LEU A N   1 
ATOM   2065 C  CA  . LEU A 1 301 ? -27.200 -13.904 -23.185 1.00 43.76  ? 564  LEU A CA  1 
ATOM   2066 C  C   . LEU A 1 301 ? -25.875 -14.715 -23.121 1.00 48.43  ? 564  LEU A C   1 
ATOM   2067 O  O   . LEU A 1 301 ? -25.335 -14.883 -22.021 1.00 41.39  ? 564  LEU A O   1 
ATOM   2068 C  CB  . LEU A 1 301 ? -28.420 -14.807 -23.397 1.00 46.44  ? 564  LEU A CB  1 
ATOM   2069 C  CG  . LEU A 1 301 ? -29.799 -14.175 -23.117 1.00 47.43  ? 564  LEU A CG  1 
ATOM   2070 C  CD1 . LEU A 1 301 ? -30.896 -15.080 -23.616 1.00 46.81  ? 564  LEU A CD1 1 
ATOM   2071 C  CD2 . LEU A 1 301 ? -30.001 -13.898 -21.629 1.00 47.82  ? 564  LEU A CD2 1 
ATOM   2072 N  N   . ALA A 1 302 ? -25.358 -15.179 -24.263 1.00 42.71  ? 565  ALA A N   1 
ATOM   2073 C  CA  . ALA A 1 302 ? -24.092 -15.953 -24.346 1.00 41.90  ? 565  ALA A CA  1 
ATOM   2074 C  C   . ALA A 1 302 ? -22.941 -15.063 -23.890 1.00 42.60  ? 565  ALA A C   1 
ATOM   2075 O  O   . ALA A 1 302 ? -22.080 -15.546 -23.145 1.00 39.92  ? 565  ALA A O   1 
ATOM   2076 C  CB  . ALA A 1 302 ? -23.854 -16.469 -25.747 1.00 39.00  ? 565  ALA A CB  1 
ATOM   2077 N  N   . GLU A 1 303 ? -22.909 -13.811 -24.350 1.00 43.71  ? 566  GLU A N   1 
ATOM   2078 C  CA  . GLU A 1 303 ? -21.842 -12.841 -23.984 1.00 44.18  ? 566  GLU A CA  1 
ATOM   2079 C  C   . GLU A 1 303 ? -21.802 -12.648 -22.469 1.00 40.61  ? 566  GLU A C   1 
ATOM   2080 O  O   . GLU A 1 303 ? -20.691 -12.480 -21.923 1.00 42.37  ? 566  GLU A O   1 
ATOM   2081 C  CB  . GLU A 1 303 ? -22.057 -11.490 -24.667 1.00 48.81  ? 566  GLU A CB  1 
ATOM   2082 C  CG  . GLU A 1 303 ? -21.605 -11.500 -26.104 1.00 52.44  ? 566  GLU A CG  1 
ATOM   2083 C  CD  . GLU A 1 303 ? -22.078 -10.310 -26.907 1.00 56.93  ? 566  GLU A CD  1 
ATOM   2084 O  OE1 . GLU A 1 303 ? -22.751 -9.462  -26.317 1.00 61.16  ? 566  GLU A OE1 1 
ATOM   2085 O  OE2 . GLU A 1 303 ? -21.780 -10.252 -28.129 1.00 55.61  ? 566  GLU A OE2 1 
ATOM   2086 N  N   . ALA A 1 304 ? -22.963 -12.649 -21.820 1.00 37.50  ? 567  ALA A N   1 
ATOM   2087 C  CA  . ALA A 1 304 ? -23.070 -12.456 -20.358 1.00 42.05  ? 567  ALA A CA  1 
ATOM   2088 C  C   . ALA A 1 304 ? -22.533 -13.703 -19.640 1.00 40.78  ? 567  ALA A C   1 
ATOM   2089 O  O   . ALA A 1 304 ? -21.834 -13.543 -18.613 1.00 39.97  ? 567  ALA A O   1 
ATOM   2090 C  CB  . ALA A 1 304 ? -24.498 -12.153 -19.949 1.00 41.62  ? 567  ALA A CB  1 
ATOM   2091 N  N   . ILE A 1 305 ? -22.857 -14.900 -20.131 1.00 41.77  ? 568  ILE A N   1 
ATOM   2092 C  CA  . ILE A 1 305 ? -22.335 -16.131 -19.483 1.00 41.15  ? 568  ILE A CA  1 
ATOM   2093 C  C   . ILE A 1 305 ? -20.802 -16.049 -19.525 1.00 35.81  ? 568  ILE A C   1 
ATOM   2094 O  O   . ILE A 1 305 ? -20.198 -16.148 -18.460 1.00 39.14  ? 568  ILE A O   1 
ATOM   2095 C  CB  . ILE A 1 305 ? -22.900 -17.416 -20.105 1.00 45.60  ? 568  ILE A CB  1 
ATOM   2096 C  CG1 . ILE A 1 305 ? -24.405 -17.554 -19.837 1.00 45.08  ? 568  ILE A CG1 1 
ATOM   2097 C  CG2 . ILE A 1 305 ? -22.104 -18.649 -19.634 1.00 42.30  ? 568  ILE A CG2 1 
ATOM   2098 C  CD1 . ILE A 1 305 ? -24.796 -17.692 -18.382 1.00 44.12  ? 568  ILE A CD1 1 
ATOM   2099 N  N   . PHE A 1 306 ? -20.194 -15.779 -20.675 1.00 35.77  ? 569  PHE A N   1 
ATOM   2100 C  CA  . PHE A 1 306 ? -18.714 -15.745 -20.810 1.00 39.76  ? 569  PHE A CA  1 
ATOM   2101 C  C   . PHE A 1 306 ? -18.122 -14.652 -19.909 1.00 48.77  ? 569  PHE A C   1 
ATOM   2102 O  O   . PHE A 1 306 ? -17.190 -14.975 -19.153 1.00 41.23  ? 569  PHE A O   1 
ATOM   2103 C  CB  . PHE A 1 306 ? -18.265 -15.546 -22.254 1.00 41.94  ? 569  PHE A CB  1 
ATOM   2104 C  CG  . PHE A 1 306 ? -18.290 -16.810 -23.073 1.00 41.11  ? 569  PHE A CG  1 
ATOM   2105 C  CD1 . PHE A 1 306 ? -17.322 -17.784 -22.887 1.00 42.43  ? 569  PHE A CD1 1 
ATOM   2106 C  CD2 . PHE A 1 306 ? -19.227 -16.991 -24.072 1.00 38.27  ? 569  PHE A CD2 1 
ATOM   2107 C  CE1 . PHE A 1 306 ? -17.336 -18.940 -23.650 1.00 41.86  ? 569  PHE A CE1 1 
ATOM   2108 C  CE2 . PHE A 1 306 ? -19.243 -18.147 -24.842 1.00 39.68  ? 569  PHE A CE2 1 
ATOM   2109 C  CZ  . PHE A 1 306 ? -18.314 -19.136 -24.601 1.00 39.05  ? 569  PHE A CZ  1 
ATOM   2110 N  N   . LYS A 1 307 ? -18.628 -13.412 -19.984 1.00 45.06  ? 570  LYS A N   1 
ATOM   2111 C  CA  . LYS A 1 307 ? -18.138 -12.246 -19.184 1.00 46.59  ? 570  LYS A CA  1 
ATOM   2112 C  C   . LYS A 1 307 ? -18.333 -12.464 -17.684 1.00 43.17  ? 570  LYS A C   1 
ATOM   2113 O  O   . LYS A 1 307 ? -17.379 -12.281 -16.942 1.00 45.86  ? 570  LYS A O   1 
ATOM   2114 C  CB  . LYS A 1 307 ? -18.877 -10.939 -19.518 1.00 54.29  ? 570  LYS A CB  1 
ATOM   2115 C  CG  . LYS A 1 307 ? -18.277 -10.111 -20.644 1.00 62.14  ? 570  LYS A CG  1 
ATOM   2116 C  CD  . LYS A 1 307 ? -18.822 -8.692  -20.687 1.00 70.40  ? 570  LYS A CD  1 
ATOM   2117 C  CE  . LYS A 1 307 ? -18.403 -7.929  -21.926 1.00 75.74  ? 570  LYS A CE  1 
ATOM   2118 N  NZ  . LYS A 1 307 ? -18.703 -8.686  -23.166 1.00 76.52  ? 570  LYS A NZ  1 
ATOM   2119 N  N   . LEU A 1 308 ? -19.541 -12.806 -17.249 1.00 41.12  ? 571  LEU A N   1 
ATOM   2120 C  CA  . LEU A 1 308 ? -19.928 -12.652 -15.824 1.00 44.14  ? 571  LEU A CA  1 
ATOM   2121 C  C   . LEU A 1 308 ? -19.619 -13.916 -15.028 1.00 45.06  ? 571  LEU A C   1 
ATOM   2122 O  O   . LEU A 1 308 ? -19.464 -13.804 -13.784 1.00 43.51  ? 571  LEU A O   1 
ATOM   2123 C  CB  . LEU A 1 308 ? -21.424 -12.297 -15.756 1.00 46.83  ? 571  LEU A CB  1 
ATOM   2124 C  CG  . LEU A 1 308 ? -21.803 -11.042 -16.558 1.00 48.25  ? 571  LEU A CG  1 
ATOM   2125 C  CD1 . LEU A 1 308 ? -23.309 -10.796 -16.534 1.00 52.84  ? 571  LEU A CD1 1 
ATOM   2126 C  CD2 . LEU A 1 308 ? -21.057 -9.821  -16.053 1.00 47.61  ? 571  LEU A CD2 1 
ATOM   2127 N  N   . THR A 1 309 ? -19.607 -15.084 -15.670 1.00 41.14  ? 572  THR A N   1 
ATOM   2128 C  CA  . THR A 1 309 ? -19.504 -16.378 -14.944 1.00 44.54  ? 572  THR A CA  1 
ATOM   2129 C  C   . THR A 1 309 ? -18.223 -17.165 -15.271 1.00 41.61  ? 572  THR A C   1 
ATOM   2130 O  O   . THR A 1 309 ? -17.769 -17.869 -14.421 1.00 42.76  ? 572  THR A O   1 
ATOM   2131 C  CB  . THR A 1 309 ? -20.774 -17.218 -15.112 1.00 46.38  ? 572  THR A CB  1 
ATOM   2132 O  OG1 . THR A 1 309 ? -20.876 -17.663 -16.461 1.00 42.54  ? 572  THR A OG1 1 
ATOM   2133 C  CG2 . THR A 1 309 ? -22.017 -16.424 -14.777 1.00 52.27  ? 572  THR A CG2 1 
ATOM   2134 N  N   . TYR A 1 310 ? -17.681 -17.027 -16.484 0.50 42.71  ? 573  TYR A N   1 
ATOM   2135 C  CA  . TYR A 1 310 ? -16.477 -17.770 -16.952 0.50 44.07  ? 573  TYR A CA  1 
ATOM   2136 C  C   . TYR A 1 310 ? -15.224 -16.910 -16.756 0.50 45.76  ? 573  TYR A C   1 
ATOM   2137 O  O   . TYR A 1 310 ? -14.251 -17.423 -16.171 0.50 48.89  ? 573  TYR A O   1 
ATOM   2138 C  CB  . TYR A 1 310 ? -16.621 -18.191 -18.420 0.50 41.51  ? 573  TYR A CB  1 
ATOM   2139 C  CG  . TYR A 1 310 ? -17.652 -19.259 -18.690 0.50 38.32  ? 573  TYR A CG  1 
ATOM   2140 C  CD1 . TYR A 1 310 ? -18.489 -19.729 -17.693 0.50 37.43  ? 573  TYR A CD1 1 
ATOM   2141 C  CD2 . TYR A 1 310 ? -17.826 -19.764 -19.966 0.50 37.63  ? 573  TYR A CD2 1 
ATOM   2142 C  CE1 . TYR A 1 310 ? -19.452 -20.690 -17.950 0.50 36.38  ? 573  TYR A CE1 1 
ATOM   2143 C  CE2 . TYR A 1 310 ? -18.781 -20.726 -20.239 0.50 36.06  ? 573  TYR A CE2 1 
ATOM   2144 C  CZ  . TYR A 1 310 ? -19.593 -21.195 -19.229 0.50 35.92  ? 573  TYR A CZ  1 
ATOM   2145 O  OH  . TYR A 1 310 ? -20.535 -22.138 -19.507 0.50 37.43  ? 573  TYR A OH  1 
ATOM   2146 N  N   . GLN A 1 311 ? -15.246 -15.659 -17.237 1.00 42.35  ? 574  GLN A N   1 
ATOM   2147 C  CA  . GLN A 1 311 ? -14.063 -14.756 -17.213 1.00 43.42  ? 574  GLN A CA  1 
ATOM   2148 C  C   . GLN A 1 311 ? -13.950 -13.963 -15.900 1.00 47.70  ? 574  GLN A C   1 
ATOM   2149 O  O   . GLN A 1 311 ? -12.904 -13.277 -15.725 1.00 45.44  ? 574  GLN A O   1 
ATOM   2150 C  CB  . GLN A 1 311 ? -14.091 -13.814 -18.404 1.00 42.88  ? 574  GLN A CB  1 
ATOM   2151 C  CG  . GLN A 1 311 ? -13.971 -14.556 -19.716 1.00 44.02  ? 574  GLN A CG  1 
ATOM   2152 C  CD  . GLN A 1 311 ? -14.268 -13.636 -20.863 1.00 44.07  ? 574  GLN A CD  1 
ATOM   2153 O  OE1 . GLN A 1 311 ? -14.707 -12.516 -20.667 1.00 59.79  ? 574  GLN A OE1 1 
ATOM   2154 N  NE2 . GLN A 1 311 ? -14.003 -14.086 -22.069 1.00 50.39  ? 574  GLN A NE2 1 
ATOM   2155 N  N   . ASN A 1 312 ? -14.990 -14.045 -15.062 1.00 51.00  ? 575  ASN A N   1 
ATOM   2156 C  CA  . ASN A 1 312 ? -15.062 -13.605 -13.643 1.00 51.47  ? 575  ASN A CA  1 
ATOM   2157 C  C   . ASN A 1 312 ? -15.857 -14.677 -12.910 1.00 52.00  ? 575  ASN A C   1 
ATOM   2158 O  O   . ASN A 1 312 ? -16.899 -15.074 -13.439 1.00 64.62  ? 575  ASN A O   1 
ATOM   2159 C  CB  . ASN A 1 312 ? -15.743 -12.240 -13.504 1.00 50.32  ? 575  ASN A CB  1 
ATOM   2160 C  CG  . ASN A 1 312 ? -14.903 -11.144 -14.104 1.00 49.16  ? 575  ASN A CG  1 
ATOM   2161 O  OD1 . ASN A 1 312 ? -13.995 -10.658 -13.452 1.00 63.48  ? 575  ASN A OD1 1 
ATOM   2162 N  ND2 . ASN A 1 312 ? -15.132 -10.814 -15.365 1.00 56.18  ? 575  ASN A ND2 1 
ATOM   2163 N  N   . LYS A 1 313 ? -15.343 -15.207 -11.809 1.00 51.02  ? 576  LYS A N   1 
ATOM   2164 C  CA  . LYS A 1 313 ? -15.971 -16.344 -11.094 1.00 54.43  ? 576  LYS A CA  1 
ATOM   2165 C  C   . LYS A 1 313 ? -16.062 -16.014 -9.607  1.00 55.58  ? 576  LYS A C   1 
ATOM   2166 O  O   . LYS A 1 313 ? -15.117 -15.419 -9.078  1.00 57.77  ? 576  LYS A O   1 
ATOM   2167 C  CB  . LYS A 1 313 ? -15.139 -17.621 -11.193 1.00 59.71  ? 576  LYS A CB  1 
ATOM   2168 C  CG  . LYS A 1 313 ? -14.696 -18.027 -12.586 1.00 62.66  ? 576  LYS A CG  1 
ATOM   2169 C  CD  . LYS A 1 313 ? -13.937 -19.327 -12.572 1.00 61.03  ? 576  LYS A CD  1 
ATOM   2170 C  CE  . LYS A 1 313 ? -13.305 -19.649 -13.904 1.00 59.25  ? 576  LYS A CE  1 
ATOM   2171 N  NZ  . LYS A 1 313 ? -12.490 -18.526 -14.412 1.00 64.86  ? 576  LYS A NZ  1 
ATOM   2172 N  N   . VAL A 1 314 ? -17.131 -16.462 -8.969  1.00 50.86  ? 577  VAL A N   1 
ATOM   2173 C  CA  . VAL A 1 314 ? -17.339 -16.347 -7.505  1.00 53.32  ? 577  VAL A CA  1 
ATOM   2174 C  C   . VAL A 1 314 ? -17.600 -17.753 -7.022  1.00 51.85  ? 577  VAL A C   1 
ATOM   2175 O  O   . VAL A 1 314 ? -18.482 -18.416 -7.591  1.00 46.22  ? 577  VAL A O   1 
ATOM   2176 C  CB  . VAL A 1 314 ? -18.513 -15.411 -7.140  1.00 58.12  ? 577  VAL A CB  1 
ATOM   2177 C  CG1 . VAL A 1 314 ? -18.865 -15.484 -5.651  1.00 59.13  ? 577  VAL A CG1 1 
ATOM   2178 C  CG2 . VAL A 1 314 ? -18.223 -13.978 -7.566  1.00 54.11  ? 577  VAL A CG2 1 
ATOM   2179 N  N   . VAL A 1 315 ? -16.868 -18.153 -5.994  1.00 52.68  ? 578  VAL A N   1 
ATOM   2180 C  CA  . VAL A 1 315 ? -16.855 -19.552 -5.509  1.00 56.91  ? 578  VAL A CA  1 
ATOM   2181 C  C   . VAL A 1 315 ? -16.921 -19.531 -3.992  1.00 57.55  ? 578  VAL A C   1 
ATOM   2182 O  O   . VAL A 1 315 ? -16.255 -18.702 -3.373  1.00 55.13  ? 578  VAL A O   1 
ATOM   2183 C  CB  . VAL A 1 315 ? -15.575 -20.258 -5.984  1.00 59.45  ? 578  VAL A CB  1 
ATOM   2184 C  CG1 . VAL A 1 315 ? -15.621 -21.743 -5.685  1.00 60.66  ? 578  VAL A CG1 1 
ATOM   2185 C  CG2 . VAL A 1 315 ? -15.309 -19.983 -7.457  1.00 63.19  ? 578  VAL A CG2 1 
ATOM   2186 N  N   . ARG A 1 316 ? -17.710 -20.443 -3.421  0.50 60.73  ? 579  ARG A N   1 
ATOM   2187 C  CA  . ARG A 1 316 ? -17.824 -20.662 -1.957  0.50 66.42  ? 579  ARG A CA  1 
ATOM   2188 C  C   . ARG A 1 316 ? -17.206 -22.023 -1.615  0.50 67.67  ? 579  ARG A C   1 
ATOM   2189 O  O   . ARG A 1 316 ? -17.785 -23.050 -2.012  0.50 67.62  ? 579  ARG A O   1 
ATOM   2190 C  CB  . ARG A 1 316 ? -19.291 -20.577 -1.530  0.50 69.37  ? 579  ARG A CB  1 
ATOM   2191 C  CG  . ARG A 1 316 ? -20.179 -21.637 -2.160  0.50 73.09  ? 579  ARG A CG  1 
ATOM   2192 C  CD  . ARG A 1 316 ? -21.570 -21.619 -1.560  0.50 77.11  ? 579  ARG A CD  1 
ATOM   2193 N  NE  . ARG A 1 316 ? -22.258 -20.361 -1.802  0.50 79.64  ? 579  ARG A NE  1 
ATOM   2194 C  CZ  . ARG A 1 316 ? -23.509 -20.113 -1.437  0.50 81.69  ? 579  ARG A CZ  1 
ATOM   2195 N  NH1 . ARG A 1 316 ? -24.055 -18.938 -1.697  0.50 82.99  ? 579  ARG A NH1 1 
ATOM   2196 N  NH2 . ARG A 1 316 ? -24.209 -21.044 -0.814  0.50 82.20  ? 579  ARG A NH2 1 
ATOM   2197 N  N   . VAL A 1 317 ? -16.070 -22.018 -0.909  0.50 69.29  ? 580  VAL A N   1 
ATOM   2198 C  CA  . VAL A 1 317 ? -15.300 -23.240 -0.528  0.50 70.89  ? 580  VAL A CA  1 
ATOM   2199 C  C   . VAL A 1 317 ? -15.330 -23.389 0.997   0.50 73.51  ? 580  VAL A C   1 
ATOM   2200 O  O   . VAL A 1 317 ? -15.073 -22.387 1.690   0.50 71.06  ? 580  VAL A O   1 
ATOM   2201 C  CB  . VAL A 1 317 ? -13.850 -23.172 -1.042  0.50 70.80  ? 580  VAL A CB  1 
ATOM   2202 C  CG1 . VAL A 1 317 ? -13.157 -24.522 -0.936  0.50 71.41  ? 580  VAL A CG1 1 
ATOM   2203 C  CG2 . VAL A 1 317 ? -13.775 -22.643 -2.465  0.50 70.70  ? 580  VAL A CG2 1 
ATOM   2204 N  N   . GLN A 1 318 ? -15.624 -24.598 1.486   0.50 79.60  ? 581  GLN A N   1 
ATOM   2205 C  CA  . GLN A 1 318 ? -15.611 -24.950 2.932   0.50 82.87  ? 581  GLN A CA  1 
ATOM   2206 C  C   . GLN A 1 318 ? -14.166 -25.179 3.383   0.50 86.57  ? 581  GLN A C   1 
ATOM   2207 O  O   . GLN A 1 318 ? -13.434 -25.901 2.674   0.50 86.35  ? 581  GLN A O   1 
ATOM   2208 C  CB  . GLN A 1 318 ? -16.449 -26.202 3.196   0.50 81.43  ? 581  GLN A CB  1 
ATOM   2209 C  CG  . GLN A 1 318 ? -17.944 -25.928 3.246   0.50 83.26  ? 581  GLN A CG  1 
ATOM   2210 C  CD  . GLN A 1 318 ? -18.670 -26.911 4.132   0.50 84.55  ? 581  GLN A CD  1 
ATOM   2211 O  OE1 . GLN A 1 318 ? -18.238 -28.047 4.317   0.50 86.41  ? 581  GLN A OE1 1 
ATOM   2212 N  NE2 . GLN A 1 318 ? -19.785 -26.474 4.694   0.50 84.26  ? 581  GLN A NE2 1 
ATOM   2213 N  N   . ARG A 1 319 ? -13.782 -24.584 4.517   0.50 90.84  ? 582  ARG A N   1 
ATOM   2214 C  CA  . ARG A 1 319 ? -12.446 -24.748 5.150   0.50 91.30  ? 582  ARG A CA  1 
ATOM   2215 C  C   . ARG A 1 319 ? -12.629 -25.336 6.545   0.50 93.98  ? 582  ARG A C   1 
ATOM   2216 O  O   . ARG A 1 319 ? -13.326 -24.757 7.375   0.50 93.55  ? 582  ARG A O   1 
ATOM   2217 C  CB  . ARG A 1 319 ? -11.715 -23.404 5.205   0.50 88.79  ? 582  ARG A CB  1 
ATOM   2218 C  CG  . ARG A 1 319 ? -10.229 -23.515 5.516   0.50 86.01  ? 582  ARG A CG  1 
ATOM   2219 C  CD  . ARG A 1 319 ? -9.449  -22.361 4.916   0.50 85.20  ? 582  ARG A CD  1 
ATOM   2220 N  NE  . ARG A 1 319 ? -10.129 -21.085 5.087   0.50 82.53  ? 582  ARG A NE  1 
ATOM   2221 C  CZ  . ARG A 1 319 ? -9.922  -20.253 6.099   0.50 83.26  ? 582  ARG A CZ  1 
ATOM   2222 N  NH1 . ARG A 1 319 ? -9.044  -20.563 7.038   0.50 84.23  ? 582  ARG A NH1 1 
ATOM   2223 N  NH2 . ARG A 1 319 ? -10.591 -19.116 6.171   0.50 81.78  ? 582  ARG A NH2 1 
ATOM   2224 N  N   . PRO A 1 320 ? -12.016 -26.506 6.839   0.50 100.30 ? 583  PRO A N   1 
ATOM   2225 C  CA  . PRO A 1 320 ? -12.166 -27.156 8.142   0.50 100.56 ? 583  PRO A CA  1 
ATOM   2226 C  C   . PRO A 1 320 ? -11.750 -26.235 9.301   0.50 100.00 ? 583  PRO A C   1 
ATOM   2227 O  O   . PRO A 1 320 ? -12.353 -26.312 10.359  0.50 99.52  ? 583  PRO A O   1 
ATOM   2228 C  CB  . PRO A 1 320 ? -11.239 -28.381 8.055   0.50 101.19 ? 583  PRO A CB  1 
ATOM   2229 C  CG  . PRO A 1 320 ? -11.083 -28.638 6.568   0.50 100.69 ? 583  PRO A CG  1 
ATOM   2230 C  CD  . PRO A 1 320 ? -11.148 -27.267 5.926   0.50 100.93 ? 583  PRO A CD  1 
ATOM   2231 N  N   . THR A 1 321 ? -10.740 -25.391 9.066   0.50 99.31  ? 584  THR A N   1 
ATOM   2232 C  CA  . THR A 1 321 ? -10.208 -24.392 10.032  0.50 98.51  ? 584  THR A CA  1 
ATOM   2233 C  C   . THR A 1 321 ? -11.362 -23.826 10.869  0.50 93.59  ? 584  THR A C   1 
ATOM   2234 O  O   . THR A 1 321 ? -11.336 -24.042 12.096  0.50 89.28  ? 584  THR A O   1 
ATOM   2235 C  CB  . THR A 1 321 ? -9.451  -23.276 9.301   0.50 100.95 ? 584  THR A CB  1 
ATOM   2236 O  OG1 . THR A 1 321 ? -10.393 -22.576 8.486   0.50 104.22 ? 584  THR A OG1 1 
ATOM   2237 C  CG2 . THR A 1 321 ? -8.314  -23.790 8.444   0.50 100.11 ? 584  THR A CG2 1 
ATOM   2238 N  N   . THR A 1 325 ? -15.535 -24.144 11.209  0.50 62.70  ? 588  THR A N   1 
ATOM   2239 C  CA  . THR A 1 325 ? -15.680 -24.201 9.729   0.50 66.29  ? 588  THR A CA  1 
ATOM   2240 C  C   . THR A 1 325 ? -16.214 -22.865 9.208   0.50 66.25  ? 588  THR A C   1 
ATOM   2241 O  O   . THR A 1 325 ? -17.275 -22.423 9.688   0.50 60.31  ? 588  THR A O   1 
ATOM   2242 C  CB  . THR A 1 325 ? -16.581 -25.361 9.290   0.50 67.89  ? 588  THR A CB  1 
ATOM   2243 O  OG1 . THR A 1 325 ? -15.961 -26.573 9.717   0.50 71.97  ? 588  THR A OG1 1 
ATOM   2244 C  CG2 . THR A 1 325 ? -16.800 -25.399 7.794   0.50 69.04  ? 588  THR A CG2 1 
ATOM   2245 N  N   . VAL A 1 326 ? -15.501 -22.259 8.258   0.50 67.31  ? 589  VAL A N   1 
ATOM   2246 C  CA  . VAL A 1 326 ? -15.958 -20.976 7.657   0.50 70.69  ? 589  VAL A CA  1 
ATOM   2247 C  C   . VAL A 1 326 ? -16.168 -21.192 6.156   0.50 71.15  ? 589  VAL A C   1 
ATOM   2248 O  O   . VAL A 1 326 ? -15.439 -22.014 5.574   0.50 70.02  ? 589  VAL A O   1 
ATOM   2249 C  CB  . VAL A 1 326 ? -14.946 -19.848 7.923   0.50 72.69  ? 589  VAL A CB  1 
ATOM   2250 C  CG1 . VAL A 1 326 ? -14.520 -19.819 9.382   0.50 74.78  ? 589  VAL A CG1 1 
ATOM   2251 C  CG2 . VAL A 1 326 ? -13.729 -19.958 7.018   0.50 73.92  ? 589  VAL A CG2 1 
ATOM   2252 N  N   . MET A 1 327 ? -17.146 -20.503 5.565   0.50 70.79  ? 590  MET A N   1 
ATOM   2253 C  CA  . MET A 1 327 ? -17.339 -20.589 4.096   0.50 70.34  ? 590  MET A CA  1 
ATOM   2254 C  C   . MET A 1 327 ? -16.471 -19.513 3.450   0.50 68.04  ? 590  MET A C   1 
ATOM   2255 O  O   . MET A 1 327 ? -16.653 -18.337 3.790   0.50 67.45  ? 590  MET A O   1 
ATOM   2256 C  CB  . MET A 1 327 ? -18.798 -20.357 3.705   0.50 71.66  ? 590  MET A CB  1 
ATOM   2257 C  CG  . MET A 1 327 ? -19.043 -20.510 2.217   0.50 71.95  ? 590  MET A CG  1 
ATOM   2258 S  SD  . MET A 1 327 ? -18.736 -22.195 1.637   0.50 71.03  ? 590  MET A SD  1 
ATOM   2259 C  CE  . MET A 1 327 ? -20.028 -23.081 2.505   0.50 71.47  ? 590  MET A CE  1 
ATOM   2260 N  N   . ASP A 1 328 ? -15.561 -19.914 2.565   0.50 68.73  ? 591  ASP A N   1 
ATOM   2261 C  CA  . ASP A 1 328 ? -14.632 -18.942 1.934   0.50 70.74  ? 591  ASP A CA  1 
ATOM   2262 C  C   . ASP A 1 328 ? -15.205 -18.471 0.594   0.50 69.49  ? 591  ASP A C   1 
ATOM   2263 O  O   . ASP A 1 328 ? -15.380 -19.314 -0.300  0.50 68.95  ? 591  ASP A O   1 
ATOM   2264 C  CB  . ASP A 1 328 ? -13.226 -19.529 1.806   0.50 72.74  ? 591  ASP A CB  1 
ATOM   2265 C  CG  . ASP A 1 328 ? -12.590 -19.861 3.144   0.50 75.26  ? 591  ASP A CG  1 
ATOM   2266 O  OD1 . ASP A 1 328 ? -12.698 -19.030 4.065   0.50 77.28  ? 591  ASP A OD1 1 
ATOM   2267 O  OD2 . ASP A 1 328 ? -12.003 -20.953 3.254   0.50 73.15  ? 591  ASP A OD2 1 
ATOM   2268 N  N   . ILE A 1 329 ? -15.494 -17.177 0.481   1.00 67.41  ? 592  ILE A N   1 
ATOM   2269 C  CA  . ILE A 1 329 ? -16.011 -16.575 -0.770  1.00 60.50  ? 592  ILE A CA  1 
ATOM   2270 C  C   . ILE A 1 329 ? -14.791 -16.027 -1.482  1.00 62.94  ? 592  ILE A C   1 
ATOM   2271 O  O   . ILE A 1 329 ? -14.247 -15.011 -1.029  1.00 62.23  ? 592  ILE A O   1 
ATOM   2272 C  CB  . ILE A 1 329 ? -17.055 -15.483 -0.469  1.00 60.30  ? 592  ILE A CB  1 
ATOM   2273 C  CG1 . ILE A 1 329 ? -18.270 -16.069 0.254   1.00 59.45  ? 592  ILE A CG1 1 
ATOM   2274 C  CG2 . ILE A 1 329 ? -17.443 -14.729 -1.733  1.00 57.97  ? 592  ILE A CG2 1 
ATOM   2275 C  CD1 . ILE A 1 329 ? -18.822 -17.327 -0.370  1.00 59.34  ? 592  ILE A CD1 1 
ATOM   2276 N  N   . ILE A 1 330 ? -14.388 -16.700 -2.557  1.00 69.83  ? 593  ILE A N   1 
ATOM   2277 C  CA  . ILE A 1 330 ? -13.144 -16.385 -3.313  1.00 65.36  ? 593  ILE A CA  1 
ATOM   2278 C  C   . ILE A 1 330 ? -13.524 -16.115 -4.767  1.00 59.18  ? 593  ILE A C   1 
ATOM   2279 O  O   . ILE A 1 330 ? -14.567 -16.601 -5.185  1.00 59.87  ? 593  ILE A O   1 
ATOM   2280 C  CB  . ILE A 1 330 ? -12.123 -17.533 -3.174  1.00 68.96  ? 593  ILE A CB  1 
ATOM   2281 C  CG1 . ILE A 1 330 ? -12.802 -18.911 -3.217  1.00 62.80  ? 593  ILE A CG1 1 
ATOM   2282 C  CG2 . ILE A 1 330 ? -11.296 -17.332 -1.912  1.00 68.82  ? 593  ILE A CG2 1 
ATOM   2283 C  CD1 . ILE A 1 330 ? -11.861 -20.072 -3.505  1.00 63.83  ? 593  ILE A CD1 1 
ATOM   2284 N  N   . SER A 1 331 ? -12.692 -15.380 -5.497  1.00 57.11  ? 594  SER A N   1 
ATOM   2285 C  CA  . SER A 1 331 ? -12.917 -15.058 -6.922  1.00 56.17  ? 594  SER A CA  1 
ATOM   2286 C  C   . SER A 1 331 ? -11.629 -15.283 -7.713  1.00 62.03  ? 594  SER A C   1 
ATOM   2287 O  O   . SER A 1 331 ? -10.550 -15.274 -7.088  1.00 61.97  ? 594  SER A O   1 
ATOM   2288 C  CB  . SER A 1 331 ? -13.415 -13.656 -7.058  1.00 57.19  ? 594  SER A CB  1 
ATOM   2289 O  OG  . SER A 1 331 ? -12.338 -12.733 -7.069  1.00 56.64  ? 594  SER A OG  1 
ATOM   2290 N  N   . ARG A 1 332 ? -11.742 -15.486 -9.032  1.00 55.31  ? 595  ARG A N   1 
ATOM   2291 C  CA  . ARG A 1 332 ? -10.603 -15.393 -9.978  1.00 52.03  ? 595  ARG A CA  1 
ATOM   2292 C  C   . ARG A 1 332 ? -11.137 -15.303 -11.395 1.00 52.14  ? 595  ARG A C   1 
ATOM   2293 O  O   . ARG A 1 332 ? -12.306 -15.649 -11.595 1.00 54.38  ? 595  ARG A O   1 
ATOM   2294 C  CB  . ARG A 1 332 ? -9.671  -16.609 -9.912  1.00 54.43  ? 595  ARG A CB  1 
ATOM   2295 C  CG  . ARG A 1 332 ? -10.235 -17.868 -10.552 1.00 51.61  ? 595  ARG A CG  1 
ATOM   2296 C  CD  . ARG A 1 332 ? -9.276  -19.017 -10.352 1.00 53.73  ? 595  ARG A CD  1 
ATOM   2297 N  NE  . ARG A 1 332 ? -7.956  -18.686 -10.874 1.00 52.24  ? 595  ARG A NE  1 
ATOM   2298 C  CZ  . ARG A 1 332 ? -6.803  -19.065 -10.337 1.00 50.64  ? 595  ARG A CZ  1 
ATOM   2299 N  NH1 . ARG A 1 332 ? -6.782  -19.820 -9.254  1.00 53.94  ? 595  ARG A NH1 1 
ATOM   2300 N  NH2 . ARG A 1 332 ? -5.667  -18.710 -10.904 1.00 50.64  ? 595  ARG A NH2 1 
ATOM   2301 N  N   . ARG A 1 333 ? -10.279 -14.895 -12.324 1.00 48.72  ? 596  ARG A N   1 
ATOM   2302 C  CA  . ARG A 1 333 ? -10.676 -14.615 -13.719 1.00 57.04  ? 596  ARG A CA  1 
ATOM   2303 C  C   . ARG A 1 333 ? -10.484 -15.876 -14.590 1.00 56.19  ? 596  ARG A C   1 
ATOM   2304 O  O   . ARG A 1 333 ? -11.353 -16.134 -15.452 1.00 59.15  ? 596  ARG A O   1 
ATOM   2305 C  CB  . ARG A 1 333 ? -9.915  -13.361 -14.149 1.00 58.48  ? 596  ARG A CB  1 
ATOM   2306 C  CG  . ARG A 1 333 ? -10.286 -12.135 -13.309 1.00 63.02  ? 596  ARG A CG  1 
ATOM   2307 C  CD  . ARG A 1 333 ? -10.269 -10.833 -14.107 1.00 68.87  ? 596  ARG A CD  1 
ATOM   2308 N  NE  . ARG A 1 333 ? -11.050 -10.939 -15.352 1.00 76.46  ? 596  ARG A NE  1 
ATOM   2309 C  CZ  . ARG A 1 333 ? -10.741 -10.368 -16.529 1.00 80.63  ? 596  ARG A CZ  1 
ATOM   2310 N  NH1 . ARG A 1 333 ? -9.655  -9.618  -16.657 1.00 81.20  ? 596  ARG A NH1 1 
ATOM   2311 N  NH2 . ARG A 1 333 ? -11.521 -10.561 -17.586 1.00 76.41  ? 596  ARG A NH2 1 
ATOM   2312 N  N   . ASP A 1 334 ? -9.432  -16.661 -14.342 1.00 48.95  ? 597  ASP A N   1 
ATOM   2313 C  CA  . ASP A 1 334 ? -8.955  -17.723 -15.270 1.00 48.70  ? 597  ASP A CA  1 
ATOM   2314 C  C   . ASP A 1 334 ? -9.308  -19.126 -14.746 1.00 43.80  ? 597  ASP A C   1 
ATOM   2315 O  O   . ASP A 1 334 ? -10.064 -19.254 -13.752 1.00 42.43  ? 597  ASP A O   1 
ATOM   2316 C  CB  . ASP A 1 334 ? -7.460  -17.536 -15.561 1.00 51.67  ? 597  ASP A CB  1 
ATOM   2317 C  CG  . ASP A 1 334 ? -6.526  -17.852 -14.403 1.00 53.05  ? 597  ASP A CG  1 
ATOM   2318 O  OD1 . ASP A 1 334 ? -7.015  -18.110 -13.274 1.00 53.17  ? 597  ASP A OD1 1 
ATOM   2319 O  OD2 . ASP A 1 334 ? -5.305  -17.886 -14.653 1.00 66.15  ? 597  ASP A OD2 1 
ATOM   2320 N  N   . GLN A 1 335 ? -8.805  -20.156 -15.443 1.00 42.61  ? 598  GLN A N   1 
ATOM   2321 C  CA  . GLN A 1 335 ? -9.088  -21.594 -15.214 1.00 40.31  ? 598  GLN A CA  1 
ATOM   2322 C  C   . GLN A 1 335 ? -10.481 -21.930 -15.721 1.00 41.18  ? 598  GLN A C   1 
ATOM   2323 O  O   . GLN A 1 335 ? -11.303 -21.002 -15.958 1.00 39.55  ? 598  GLN A O   1 
ATOM   2324 C  CB  . GLN A 1 335 ? -8.978  -22.002 -13.741 1.00 41.59  ? 598  GLN A CB  1 
ATOM   2325 C  CG  . GLN A 1 335 ? -7.594  -21.743 -13.170 1.00 44.63  ? 598  GLN A CG  1 
ATOM   2326 C  CD  . GLN A 1 335 ? -7.310  -22.421 -11.854 1.00 46.41  ? 598  GLN A CD  1 
ATOM   2327 O  OE1 . GLN A 1 335 ? -8.157  -23.082 -11.255 1.00 51.63  ? 598  GLN A OE1 1 
ATOM   2328 N  NE2 . GLN A 1 335 ? -6.077  -22.269 -11.419 1.00 45.92  ? 598  GLN A NE2 1 
ATOM   2329 N  N   . ARG A 1 336 ? -10.748 -23.229 -15.879 0.50 42.98  ? 599  ARG A N   1 
ATOM   2330 C  CA  . ARG A 1 336 ? -12.069 -23.769 -16.290 0.50 43.01  ? 599  ARG A CA  1 
ATOM   2331 C  C   . ARG A 1 336 ? -12.947 -23.981 -15.054 0.50 47.83  ? 599  ARG A C   1 
ATOM   2332 O  O   . ARG A 1 336 ? -12.501 -24.651 -14.101 0.50 47.08  ? 599  ARG A O   1 
ATOM   2333 C  CB  . ARG A 1 336 ? -11.938 -25.088 -17.050 0.50 41.56  ? 599  ARG A CB  1 
ATOM   2334 C  CG  . ARG A 1 336 ? -13.281 -25.681 -17.449 0.50 38.94  ? 599  ARG A CG  1 
ATOM   2335 C  CD  . ARG A 1 336 ? -13.847 -24.966 -18.657 0.50 37.91  ? 599  ARG A CD  1 
ATOM   2336 N  NE  . ARG A 1 336 ? -13.031 -25.253 -19.818 0.50 35.20  ? 599  ARG A NE  1 
ATOM   2337 C  CZ  . ARG A 1 336 ? -12.776 -24.394 -20.790 0.50 34.04  ? 599  ARG A CZ  1 
ATOM   2338 N  NH1 . ARG A 1 336 ? -13.280 -23.172 -20.741 0.50 34.22  ? 599  ARG A NH1 1 
ATOM   2339 N  NH2 . ARG A 1 336 ? -12.020 -24.766 -21.806 0.50 32.10  ? 599  ARG A NH2 1 
ATOM   2340 N  N   . GLY A 1 337 ? -14.162 -23.440 -15.102 0.50 53.02  ? 600  GLY A N   1 
ATOM   2341 C  CA  . GLY A 1 337 ? -15.186 -23.542 -14.047 0.50 58.75  ? 600  GLY A CA  1 
ATOM   2342 C  C   . GLY A 1 337 ? -16.545 -23.234 -14.638 0.50 62.65  ? 600  GLY A C   1 
ATOM   2343 O  O   . GLY A 1 337 ? -16.972 -22.063 -14.573 0.50 73.50  ? 600  GLY A O   1 
ATOM   2344 N  N   . SER A 1 338 ? -17.154 -24.243 -15.262 0.50 62.97  ? 601  SER A N   1 
ATOM   2345 C  CA  . SER A 1 338 ? -18.438 -24.171 -16.001 0.50 58.21  ? 601  SER A CA  1 
ATOM   2346 C  C   . SER A 1 338 ? -19.178 -25.487 -15.760 0.50 56.99  ? 601  SER A C   1 
ATOM   2347 O  O   . SER A 1 338 ? -18.649 -26.309 -14.993 0.50 53.67  ? 601  SER A O   1 
ATOM   2348 C  CB  . SER A 1 338 ? -18.200 -23.918 -17.469 0.50 59.59  ? 601  SER A CB  1 
ATOM   2349 O  OG  . SER A 1 338 ? -17.052 -23.102 -17.663 0.50 60.66  ? 601  SER A OG  1 
ATOM   2350 N  N   . GLY A 1 339 ? -20.343 -25.681 -16.384 1.00 59.08  ? 602  GLY A N   1 
ATOM   2351 C  CA  . GLY A 1 339 ? -21.050 -26.971 -16.308 1.00 57.87  ? 602  GLY A CA  1 
ATOM   2352 C  C   . GLY A 1 339 ? -20.147 -28.031 -16.912 1.00 51.41  ? 602  GLY A C   1 
ATOM   2353 O  O   . GLY A 1 339 ? -19.311 -27.656 -17.744 1.00 39.16  ? 602  GLY A O   1 
ATOM   2354 N  N   . GLN A 1 340 ? -20.258 -29.287 -16.481 1.00 51.05  ? 603  GLN A N   1 
ATOM   2355 C  CA  . GLN A 1 340 ? -19.372 -30.360 -16.996 1.00 53.62  ? 603  GLN A CA  1 
ATOM   2356 C  C   . GLN A 1 340 ? -19.614 -30.531 -18.506 1.00 51.66  ? 603  GLN A C   1 
ATOM   2357 O  O   . GLN A 1 340 ? -18.648 -30.814 -19.224 1.00 44.68  ? 603  GLN A O   1 
ATOM   2358 C  CB  . GLN A 1 340 ? -19.526 -31.639 -16.163 1.00 64.68  ? 603  GLN A CB  1 
ATOM   2359 C  CG  . GLN A 1 340 ? -20.963 -31.964 -15.770 1.00 78.64  ? 603  GLN A CG  1 
ATOM   2360 C  CD  . GLN A 1 340 ? -21.179 -33.424 -15.443 1.00 83.76  ? 603  GLN A CD  1 
ATOM   2361 O  OE1 . GLN A 1 340 ? -22.289 -33.958 -15.555 1.00 91.61  ? 603  GLN A OE1 1 
ATOM   2362 N  NE2 . GLN A 1 340 ? -20.108 -34.086 -15.039 1.00 83.53  ? 603  GLN A NE2 1 
ATOM   2363 N  N   . VAL A 1 341 ? -20.835 -30.341 -19.018 1.00 49.11  ? 604  VAL A N   1 
ATOM   2364 C  CA  . VAL A 1 341 ? -21.110 -30.587 -20.469 1.00 44.53  ? 604  VAL A CA  1 
ATOM   2365 C  C   . VAL A 1 341 ? -20.538 -29.447 -21.317 1.00 43.03  ? 604  VAL A C   1 
ATOM   2366 O  O   . VAL A 1 341 ? -19.900 -29.753 -22.394 1.00 34.05  ? 604  VAL A O   1 
ATOM   2367 C  CB  . VAL A 1 341 ? -22.608 -30.797 -20.746 1.00 44.07  ? 604  VAL A CB  1 
ATOM   2368 C  CG1 . VAL A 1 341 ? -22.855 -30.826 -22.249 1.00 48.53  ? 604  VAL A CG1 1 
ATOM   2369 C  CG2 . VAL A 1 341 ? -23.114 -32.069 -20.069 1.00 47.13  ? 604  VAL A CG2 1 
ATOM   2370 N  N   . VAL A 1 342 ? -20.772 -28.183 -20.912 1.00 36.85  ? 605  VAL A N   1 
ATOM   2371 C  CA  . VAL A 1 342 ? -20.083 -27.042 -21.588 1.00 33.20  ? 605  VAL A CA  1 
ATOM   2372 C  C   . VAL A 1 342 ? -18.562 -27.158 -21.409 1.00 33.38  ? 605  VAL A C   1 
ATOM   2373 O  O   . VAL A 1 342 ? -17.829 -26.911 -22.374 1.00 27.84  ? 605  VAL A O   1 
ATOM   2374 C  CB  . VAL A 1 342 ? -20.646 -25.693 -21.127 1.00 36.29  ? 605  VAL A CB  1 
ATOM   2375 C  CG1 . VAL A 1 342 ? -19.868 -24.532 -21.728 1.00 35.40  ? 605  VAL A CG1 1 
ATOM   2376 C  CG2 . VAL A 1 342 ? -22.120 -25.600 -21.518 1.00 37.56  ? 605  VAL A CG2 1 
ATOM   2377 N  N   . THR A 1 343 ? -18.079 -27.580 -20.249 1.00 28.10  ? 606  THR A N   1 
ATOM   2378 C  CA  . THR A 1 343 ? -16.624 -27.822 -20.055 1.00 30.33  ? 606  THR A CA  1 
ATOM   2379 C  C   . THR A 1 343 ? -16.075 -28.797 -21.115 1.00 26.89  ? 606  THR A C   1 
ATOM   2380 O  O   . THR A 1 343 ? -14.967 -28.587 -21.561 1.00 27.67  ? 606  THR A O   1 
ATOM   2381 C  CB  . THR A 1 343 ? -16.327 -28.355 -18.651 1.00 33.15  ? 606  THR A CB  1 
ATOM   2382 O  OG1 . THR A 1 343 ? -16.624 -27.246 -17.805 1.00 36.46  ? 606  THR A OG1 1 
ATOM   2383 C  CG2 . THR A 1 343 ? -14.888 -28.819 -18.502 1.00 35.64  ? 606  THR A CG2 1 
ATOM   2384 N  N   . TYR A 1 344 ? -16.801 -29.859 -21.458 1.00 27.40  ? 607  TYR A N   1 
ATOM   2385 C  CA  . TYR A 1 344 ? -16.326 -30.887 -22.396 1.00 26.39  ? 607  TYR A CA  1 
ATOM   2386 C  C   . TYR A 1 344 ? -16.143 -30.223 -23.764 1.00 28.12  ? 607  TYR A C   1 
ATOM   2387 O  O   . TYR A 1 344 ? -15.096 -30.425 -24.411 1.00 25.36  ? 607  TYR A O   1 
ATOM   2388 C  CB  . TYR A 1 344 ? -17.279 -32.079 -22.450 1.00 28.99  ? 607  TYR A CB  1 
ATOM   2389 C  CG  . TYR A 1 344 ? -16.925 -33.085 -23.519 1.00 28.42  ? 607  TYR A CG  1 
ATOM   2390 C  CD1 . TYR A 1 344 ? -15.959 -34.046 -23.260 1.00 29.44  ? 607  TYR A CD1 1 
ATOM   2391 C  CD2 . TYR A 1 344 ? -17.456 -33.025 -24.800 1.00 29.45  ? 607  TYR A CD2 1 
ATOM   2392 C  CE1 . TYR A 1 344 ? -15.580 -34.966 -24.217 1.00 28.13  ? 607  TYR A CE1 1 
ATOM   2393 C  CE2 . TYR A 1 344 ? -17.098 -33.952 -25.768 1.00 32.07  ? 607  TYR A CE2 1 
ATOM   2394 C  CZ  . TYR A 1 344 ? -16.158 -34.933 -25.468 1.00 31.52  ? 607  TYR A CZ  1 
ATOM   2395 O  OH  . TYR A 1 344 ? -15.734 -35.840 -26.394 1.00 34.22  ? 607  TYR A OH  1 
ATOM   2396 N  N   . GLY A 1 345 ? -17.147 -29.472 -24.235 1.00 24.37  ? 608  GLY A N   1 
ATOM   2397 C  CA  . GLY A 1 345 ? -17.092 -28.892 -25.596 1.00 22.82  ? 608  GLY A CA  1 
ATOM   2398 C  C   . GLY A 1 345 ? -15.990 -27.843 -25.730 1.00 21.93  ? 608  GLY A C   1 
ATOM   2399 O  O   . GLY A 1 345 ? -15.276 -27.841 -26.717 1.00 27.48  ? 608  GLY A O   1 
ATOM   2400 N  N   . LEU A 1 346 ? -15.838 -26.977 -24.730 0.50 23.45  ? 609  LEU A N   1 
ATOM   2401 C  CA  . LEU A 1 346 ? -14.834 -25.882 -24.771 0.50 25.54  ? 609  LEU A CA  1 
ATOM   2402 C  C   . LEU A 1 346 ? -13.421 -26.463 -24.594 0.50 24.66  ? 609  LEU A C   1 
ATOM   2403 O  O   . LEU A 1 346 ? -12.493 -25.935 -25.231 0.50 24.96  ? 609  LEU A O   1 
ATOM   2404 C  CB  . LEU A 1 346 ? -15.166 -24.854 -23.692 0.50 26.90  ? 609  LEU A CB  1 
ATOM   2405 C  CG  . LEU A 1 346 ? -16.470 -24.094 -23.920 0.50 27.51  ? 609  LEU A CG  1 
ATOM   2406 C  CD1 . LEU A 1 346 ? -16.645 -23.014 -22.863 0.50 29.85  ? 609  LEU A CD1 1 
ATOM   2407 C  CD2 . LEU A 1 346 ? -16.492 -23.489 -25.314 0.50 27.34  ? 609  LEU A CD2 1 
ATOM   2408 N  N   . ASN A 1 347 ? -13.275 -27.493 -23.760 1.00 24.47  ? 610  ASN A N   1 
ATOM   2409 C  CA  . ASN A 1 347 ? -11.999 -28.264 -23.640 1.00 23.69  ? 610  ASN A CA  1 
ATOM   2410 C  C   . ASN A 1 347 ? -11.657 -28.872 -24.999 1.00 22.62  ? 610  ASN A C   1 
ATOM   2411 O  O   . ASN A 1 347 ? -10.490 -28.737 -25.417 1.00 25.56  ? 610  ASN A O   1 
ATOM   2412 C  CB  . ASN A 1 347 ? -12.078 -29.328 -22.539 1.00 23.69  ? 610  ASN A CB  1 
ATOM   2413 C  CG  . ASN A 1 347 ? -11.895 -28.720 -21.169 1.00 27.14  ? 610  ASN A CG  1 
ATOM   2414 O  OD1 . ASN A 1 347 ? -11.523 -27.552 -21.028 1.00 27.65  ? 610  ASN A OD1 1 
ATOM   2415 N  ND2 . ASN A 1 347 ? -12.060 -29.529 -20.142 1.00 28.50  ? 610  ASN A ND2 1 
ATOM   2416 N  N   . THR A 1 348 ? -12.613 -29.508 -25.686 1.00 23.35  ? 611  THR A N   1 
ATOM   2417 C  CA  . THR A 1 348 ? -12.393 -30.091 -27.032 1.00 23.72  ? 611  THR A CA  1 
ATOM   2418 C  C   . THR A 1 348 ? -11.925 -28.970 -27.987 1.00 25.74  ? 611  THR A C   1 
ATOM   2419 O  O   . THR A 1 348 ? -10.939 -29.179 -28.745 1.00 23.63  ? 611  THR A O   1 
ATOM   2420 C  CB  . THR A 1 348 ? -13.619 -30.834 -27.550 1.00 24.46  ? 611  THR A CB  1 
ATOM   2421 O  OG1 . THR A 1 348 ? -14.020 -31.829 -26.595 1.00 23.88  ? 611  THR A OG1 1 
ATOM   2422 C  CG2 . THR A 1 348 ? -13.348 -31.456 -28.891 1.00 22.58  ? 611  THR A CG2 1 
ATOM   2423 N  N   . PHE A 1 349 ? -12.623 -27.829 -27.988 1.00 24.22  ? 612  PHE A N   1 
ATOM   2424 C  CA  . PHE A 1 349 ? -12.323 -26.701 -28.904 1.00 26.07  ? 612  PHE A CA  1 
ATOM   2425 C  C   . PHE A 1 349 ? -10.872 -26.222 -28.710 1.00 25.14  ? 612  PHE A C   1 
ATOM   2426 O  O   . PHE A 1 349 ? -10.112 -26.123 -29.679 1.00 25.97  ? 612  PHE A O   1 
ATOM   2427 C  CB  . PHE A 1 349 ? -13.285 -25.558 -28.606 1.00 26.20  ? 612  PHE A CB  1 
ATOM   2428 C  CG  . PHE A 1 349 ? -13.011 -24.381 -29.492 1.00 25.64  ? 612  PHE A CG  1 
ATOM   2429 C  CD1 . PHE A 1 349 ? -13.547 -24.328 -30.759 1.00 28.96  ? 612  PHE A CD1 1 
ATOM   2430 C  CD2 . PHE A 1 349 ? -12.144 -23.395 -29.076 1.00 26.52  ? 612  PHE A CD2 1 
ATOM   2431 C  CE1 . PHE A 1 349 ? -13.273 -23.245 -31.587 1.00 31.01  ? 612  PHE A CE1 1 
ATOM   2432 C  CE2 . PHE A 1 349 ? -11.864 -22.324 -29.911 1.00 29.08  ? 612  PHE A CE2 1 
ATOM   2433 C  CZ  . PHE A 1 349 ? -12.439 -22.243 -31.145 1.00 29.27  ? 612  PHE A CZ  1 
ATOM   2434 N  N   . THR A 1 350 ? -10.507 -25.950 -27.461 1.00 23.49  ? 613  THR A N   1 
ATOM   2435 C  CA  . THR A 1 350 ? -9.213  -25.314 -27.097 1.00 27.95  ? 613  THR A CA  1 
ATOM   2436 C  C   . THR A 1 350 ? -8.083  -26.343 -27.260 1.00 26.30  ? 613  THR A C   1 
ATOM   2437 O  O   . THR A 1 350 ? -6.986  -25.970 -27.728 1.00 27.48  ? 613  THR A O   1 
ATOM   2438 C  CB  . THR A 1 350 ? -9.280  -24.729 -25.685 1.00 28.63  ? 613  THR A CB  1 
ATOM   2439 O  OG1 . THR A 1 350 ? -10.221 -23.655 -25.746 1.00 29.01  ? 613  THR A OG1 1 
ATOM   2440 C  CG2 . THR A 1 350 ? -7.934  -24.213 -25.215 1.00 31.75  ? 613  THR A CG2 1 
ATOM   2441 N  N   . ASN A 1 351 ? -8.384  -27.622 -27.056 1.00 24.00  ? 614  ASN A N   1 
ATOM   2442 C  CA  . ASN A 1 351 ? -7.437  -28.724 -27.351 1.00 25.77  ? 614  ASN A CA  1 
ATOM   2443 C  C   . ASN A 1 351 ? -7.235  -28.839 -28.869 1.00 25.55  ? 614  ASN A C   1 
ATOM   2444 O  O   . ASN A 1 351 ? -6.086  -28.954 -29.299 1.00 24.32  ? 614  ASN A O   1 
ATOM   2445 C  CB  . ASN A 1 351 ? -7.868  -30.021 -26.650 1.00 23.03  ? 614  ASN A CB  1 
ATOM   2446 C  CG  . ASN A 1 351 ? -6.697  -30.949 -26.379 1.00 28.09  ? 614  ASN A CG  1 
ATOM   2447 O  OD1 . ASN A 1 351 ? -5.523  -30.597 -26.578 1.00 26.26  ? 614  ASN A OD1 1 
ATOM   2448 N  ND2 . ASN A 1 351 ? -7.004  -32.142 -25.897 1.00 28.14  ? 614  ASN A ND2 1 
ATOM   2449 N  N   . MET A 1 352 ? -8.299  -28.776 -29.675 1.00 23.76  ? 615  MET A N   1 
ATOM   2450 C  CA  . MET A 1 352 ? -8.151  -28.859 -31.147 1.00 24.78  ? 615  MET A CA  1 
ATOM   2451 C  C   . MET A 1 352 ? -7.262  -27.688 -31.610 1.00 27.60  ? 615  MET A C   1 
ATOM   2452 O  O   . MET A 1 352 ? -6.352  -27.892 -32.451 1.00 26.09  ? 615  MET A O   1 
ATOM   2453 C  CB  . MET A 1 352 ? -9.490  -28.777 -31.897 1.00 25.85  ? 615  MET A CB  1 
ATOM   2454 C  CG  . MET A 1 352 ? -10.316 -30.014 -31.770 1.00 26.71  ? 615  MET A CG  1 
ATOM   2455 S  SD  . MET A 1 352 ? -12.041 -29.737 -32.369 1.00 29.99  ? 615  MET A SD  1 
ATOM   2456 C  CE  . MET A 1 352 ? -11.780 -29.497 -34.104 1.00 26.39  ? 615  MET A CE  1 
ATOM   2457 N  N   . GLU A 1 353 ? -7.488  -26.520 -31.061 1.00 25.53  ? 616  GLU A N   1 
ATOM   2458 C  CA  . GLU A 1 353 ? -6.690  -25.310 -31.424 1.00 25.59  ? 616  GLU A CA  1 
ATOM   2459 C  C   . GLU A 1 353 ? -5.194  -25.525 -31.077 1.00 25.96  ? 616  GLU A C   1 
ATOM   2460 O  O   . GLU A 1 353 ? -4.315  -25.261 -31.911 1.00 27.92  ? 616  GLU A O   1 
ATOM   2461 C  CB  . GLU A 1 353 ? -7.284  -24.167 -30.608 1.00 28.90  ? 616  GLU A CB  1 
ATOM   2462 C  CG  . GLU A 1 353 ? -6.684  -22.800 -30.899 1.00 32.79  ? 616  GLU A CG  1 
ATOM   2463 C  CD  . GLU A 1 353 ? -6.973  -21.822 -29.770 1.00 35.47  ? 616  GLU A CD  1 
ATOM   2464 O  OE1 . GLU A 1 353 ? -8.198  -21.473 -29.581 1.00 37.84  ? 616  GLU A OE1 1 
ATOM   2465 O  OE2 . GLU A 1 353 ? -6.016  -21.546 -28.973 1.00 33.85  ? 616  GLU A OE2 1 
ATOM   2466 N  N   . ALA A 1 354 ? -4.915  -25.901 -29.838 1.00 25.66  ? 617  ALA A N   1 
ATOM   2467 C  CA  . ALA A 1 354 ? -3.562  -26.132 -29.316 1.00 26.29  ? 617  ALA A CA  1 
ATOM   2468 C  C   . ALA A 1 354 ? -2.846  -27.185 -30.163 1.00 28.28  ? 617  ALA A C   1 
ATOM   2469 O  O   . ALA A 1 354 ? -1.665  -26.975 -30.471 1.00 27.39  ? 617  ALA A O   1 
ATOM   2470 C  CB  . ALA A 1 354 ? -3.637  -26.509 -27.880 1.00 27.01  ? 617  ALA A CB  1 
ATOM   2471 N  N   . GLN A 1 355 ? -3.504  -28.291 -30.523 1.00 23.34  ? 618  GLN A N   1 
ATOM   2472 C  CA  . GLN A 1 355 ? -2.861  -29.370 -31.297 1.00 24.24  ? 618  GLN A CA  1 
ATOM   2473 C  C   . GLN A 1 355 ? -2.606  -28.918 -32.745 1.00 25.11  ? 618  GLN A C   1 
ATOM   2474 O  O   . GLN A 1 355 ? -1.579  -29.324 -33.306 1.00 25.16  ? 618  GLN A O   1 
ATOM   2475 C  CB  . GLN A 1 355 ? -3.634  -30.694 -31.221 1.00 22.44  ? 618  GLN A CB  1 
ATOM   2476 C  CG  . GLN A 1 355 ? -3.870  -31.195 -29.811 1.00 22.83  ? 618  GLN A CG  1 
ATOM   2477 C  CD  . GLN A 1 355 ? -2.603  -31.345 -29.006 1.00 26.72  ? 618  GLN A CD  1 
ATOM   2478 O  OE1 . GLN A 1 355 ? -1.557  -31.745 -29.503 1.00 27.01  ? 618  GLN A OE1 1 
ATOM   2479 N  NE2 . GLN A 1 355 ? -2.713  -31.080 -27.723 1.00 26.76  ? 618  GLN A NE2 1 
ATOM   2480 N  N   . LEU A 1 356 ? -3.472  -28.126 -33.363 1.00 24.40  ? 619  LEU A N   1 
ATOM   2481 C  CA  . LEU A 1 356 ? -3.201  -27.590 -34.738 1.00 26.66  ? 619  LEU A CA  1 
ATOM   2482 C  C   . LEU A 1 356 ? -1.986  -26.654 -34.677 1.00 25.67  ? 619  LEU A C   1 
ATOM   2483 O  O   . LEU A 1 356 ? -1.161  -26.705 -35.598 1.00 31.68  ? 619  LEU A O   1 
ATOM   2484 C  CB  . LEU A 1 356 ? -4.364  -26.749 -35.272 1.00 29.10  ? 619  LEU A CB  1 
ATOM   2485 C  CG  . LEU A 1 356 ? -5.516  -27.490 -35.907 1.00 31.60  ? 619  LEU A CG  1 
ATOM   2486 C  CD1 . LEU A 1 356 ? -6.668  -26.506 -36.134 1.00 34.36  ? 619  LEU A CD1 1 
ATOM   2487 C  CD2 . LEU A 1 356 ? -5.111  -28.179 -37.209 1.00 32.26  ? 619  LEU A CD2 1 
ATOM   2488 N  N   . ILE A 1 357 ? -1.847  -25.890 -33.615 1.00 26.89  ? 620  ILE A N   1 
ATOM   2489 C  CA  . ILE A 1 357 ? -0.685  -24.958 -33.477 1.00 28.86  ? 620  ILE A CA  1 
ATOM   2490 C  C   . ILE A 1 357 ? 0.577   -25.798 -33.252 1.00 33.28  ? 620  ILE A C   1 
ATOM   2491 O  O   . ILE A 1 357 ? 1.579   -25.511 -33.924 1.00 30.43  ? 620  ILE A O   1 
ATOM   2492 C  CB  . ILE A 1 357 ? -0.921  -23.918 -32.387 1.00 31.43  ? 620  ILE A CB  1 
ATOM   2493 C  CG1 . ILE A 1 357 ? -2.125  -23.038 -32.767 1.00 32.53  ? 620  ILE A CG1 1 
ATOM   2494 C  CG2 . ILE A 1 357 ? 0.349   -23.119 -32.112 1.00 33.06  ? 620  ILE A CG2 1 
ATOM   2495 C  CD1 . ILE A 1 357 ? -2.618  -22.169 -31.665 1.00 32.05  ? 620  ILE A CD1 1 
ATOM   2496 N  N   . ARG A 1 358 ? 0.513   -26.860 -32.432 1.00 30.18  ? 621  ARG A N   1 
ATOM   2497 C  CA  . ARG A 1 358 ? 1.683   -27.747 -32.299 1.00 27.61  ? 621  ARG A CA  1 
ATOM   2498 C  C   . ARG A 1 358 ? 2.014   -28.337 -33.663 1.00 27.99  ? 621  ARG A C   1 
ATOM   2499 O  O   . ARG A 1 358 ? 3.237   -28.410 -33.993 1.00 28.91  ? 621  ARG A O   1 
ATOM   2500 C  CB  . ARG A 1 358 ? 1.518   -28.774 -31.187 1.00 28.41  ? 621  ARG A CB  1 
ATOM   2501 C  CG  . ARG A 1 358 ? 2.751   -29.643 -31.038 1.00 28.76  ? 621  ARG A CG  1 
ATOM   2502 C  CD  . ARG A 1 358 ? 2.647   -30.534 -29.828 1.00 30.55  ? 621  ARG A CD  1 
ATOM   2503 N  NE  . ARG A 1 358 ? 3.828   -31.403 -29.737 1.00 28.42  ? 621  ARG A NE  1 
ATOM   2504 C  CZ  . ARG A 1 358 ? 4.001   -32.384 -28.856 1.00 29.81  ? 621  ARG A CZ  1 
ATOM   2505 N  NH1 . ARG A 1 358 ? 3.032   -32.749 -28.030 1.00 25.75  ? 621  ARG A NH1 1 
ATOM   2506 N  NH2 . ARG A 1 358 ? 5.169   -33.022 -28.831 1.00 29.79  ? 621  ARG A NH2 1 
ATOM   2507 N  N   . GLN A 1 359 ? 1.032   -28.817 -34.421 1.00 25.71  ? 622  GLN A N   1 
ATOM   2508 C  CA  . GLN A 1 359 ? 1.284   -29.329 -35.786 1.00 24.84  ? 622  GLN A CA  1 
ATOM   2509 C  C   . GLN A 1 359 ? 1.939   -28.197 -36.627 1.00 29.99  ? 622  GLN A C   1 
ATOM   2510 O  O   . GLN A 1 359 ? 2.865   -28.496 -37.401 1.00 34.38  ? 622  GLN A O   1 
ATOM   2511 C  CB  . GLN A 1 359 ? 0.047   -29.864 -36.485 1.00 26.39  ? 622  GLN A CB  1 
ATOM   2512 C  CG  . GLN A 1 359 ? -0.481  -31.195 -35.960 1.00 24.93  ? 622  GLN A CG  1 
ATOM   2513 C  CD  . GLN A 1 359 ? -1.477  -31.828 -36.884 1.00 26.01  ? 622  GLN A CD  1 
ATOM   2514 O  OE1 . GLN A 1 359 ? -1.146  -32.278 -37.975 1.00 27.00  ? 622  GLN A OE1 1 
ATOM   2515 N  NE2 . GLN A 1 359 ? -2.739  -31.860 -36.456 1.00 27.48  ? 622  GLN A NE2 1 
ATOM   2516 N  N   . MET A 1 360 ? 1.470   -26.956 -36.567 1.00 28.38  ? 623  MET A N   1 
ATOM   2517 C  CA  . MET A 1 360 ? 2.085   -25.859 -37.385 1.00 33.06  ? 623  MET A CA  1 
ATOM   2518 C  C   . MET A 1 360 ? 3.570   -25.707 -36.985 1.00 31.10  ? 623  MET A C   1 
ATOM   2519 O  O   . MET A 1 360 ? 4.397   -25.535 -37.884 1.00 32.05  ? 623  MET A O   1 
ATOM   2520 C  CB  . MET A 1 360 ? 1.418   -24.504 -37.143 1.00 35.26  ? 623  MET A CB  1 
ATOM   2521 C  CG  . MET A 1 360 ? 0.074   -24.326 -37.785 1.00 36.80  ? 623  MET A CG  1 
ATOM   2522 S  SD  . MET A 1 360 ? -0.611  -22.802 -37.089 1.00 38.41  ? 623  MET A SD  1 
ATOM   2523 C  CE  . MET A 1 360 ? -2.367  -23.120 -37.223 1.00 38.60  ? 623  MET A CE  1 
ATOM   2524 N  N   . GLU A 1 361 ? 3.867   -25.718 -35.691 1.00 29.49  ? 624  GLU A N   1 
ATOM   2525 C  CA  . GLU A 1 361 ? 5.245   -25.582 -35.176 1.00 32.93  ? 624  GLU A CA  1 
ATOM   2526 C  C   . GLU A 1 361 ? 6.101   -26.688 -35.764 1.00 38.02  ? 624  GLU A C   1 
ATOM   2527 O  O   . GLU A 1 361 ? 7.233   -26.399 -36.154 1.00 35.42  ? 624  GLU A O   1 
ATOM   2528 C  CB  . GLU A 1 361 ? 5.289   -25.614 -33.650 1.00 34.45  ? 624  GLU A CB  1 
ATOM   2529 C  CG  . GLU A 1 361 ? 6.651   -25.228 -33.113 1.00 38.12  ? 624  GLU A CG  1 
ATOM   2530 C  CD  . GLU A 1 361 ? 6.745   -24.979 -31.616 1.00 38.16  ? 624  GLU A CD  1 
ATOM   2531 O  OE1 . GLU A 1 361 ? 7.869   -24.957 -31.101 1.00 40.99  ? 624  GLU A OE1 1 
ATOM   2532 O  OE2 . GLU A 1 361 ? 5.695   -24.788 -30.950 1.00 37.51  ? 624  GLU A OE2 1 
ATOM   2533 N  N   . GLY A 1 362 ? 5.623   -27.931 -35.792 1.00 32.68  ? 625  GLY A N   1 
ATOM   2534 C  CA  . GLY A 1 362 ? 6.439   -29.056 -36.291 1.00 35.08  ? 625  GLY A CA  1 
ATOM   2535 C  C   . GLY A 1 362 ? 6.704   -28.923 -37.791 1.00 36.77  ? 625  GLY A C   1 
ATOM   2536 O  O   . GLY A 1 362 ? 7.757   -29.376 -38.267 1.00 32.53  ? 625  GLY A O   1 
ATOM   2537 N  N   . GLU A 1 363 ? 5.751   -28.353 -38.523 1.00 28.42  ? 626  GLU A N   1 
ATOM   2538 C  CA  . GLU A 1 363 ? 5.849   -28.205 -39.986 1.00 30.12  ? 626  GLU A CA  1 
ATOM   2539 C  C   . GLU A 1 363 ? 6.629   -26.913 -40.321 1.00 32.03  ? 626  GLU A C   1 
ATOM   2540 O  O   . GLU A 1 363 ? 6.731   -26.586 -41.475 1.00 30.48  ? 626  GLU A O   1 
ATOM   2541 C  CB  . GLU A 1 363 ? 4.445   -28.219 -40.584 1.00 30.39  ? 626  GLU A CB  1 
ATOM   2542 C  CG  . GLU A 1 363 ? 3.864   -29.640 -40.672 1.00 32.01  ? 626  GLU A CG  1 
ATOM   2543 C  CD  . GLU A 1 363 ? 2.439   -29.675 -41.189 1.00 38.06  ? 626  GLU A CD  1 
ATOM   2544 O  OE1 . GLU A 1 363 ? 2.214   -29.056 -42.277 1.00 33.83  ? 626  GLU A OE1 1 
ATOM   2545 O  OE2 . GLU A 1 363 ? 1.545   -30.290 -40.490 1.00 31.89  ? 626  GLU A OE2 1 
ATOM   2546 N  N   . GLY A 1 364 ? 7.054   -26.144 -39.351 1.00 30.45  ? 627  GLY A N   1 
ATOM   2547 C  CA  . GLY A 1 364 ? 7.851   -24.923 -39.592 1.00 39.36  ? 627  GLY A CA  1 
ATOM   2548 C  C   . GLY A 1 364 ? 7.036   -23.760 -40.133 1.00 45.30  ? 627  GLY A C   1 
ATOM   2549 O  O   . GLY A 1 364 ? 7.660   -22.867 -40.770 1.00 42.37  ? 627  GLY A O   1 
ATOM   2550 N  N   . VAL A 1 365 ? 5.715   -23.704 -39.881 1.00 36.65  ? 628  VAL A N   1 
ATOM   2551 C  CA  . VAL A 1 365 ? 4.829   -22.662 -40.470 1.00 36.95  ? 628  VAL A CA  1 
ATOM   2552 C  C   . VAL A 1 365 ? 5.244   -21.290 -39.927 1.00 37.83  ? 628  VAL A C   1 
ATOM   2553 O  O   . VAL A 1 365 ? 5.031   -20.311 -40.625 1.00 42.73  ? 628  VAL A O   1 
ATOM   2554 C  CB  . VAL A 1 365 ? 3.340   -22.975 -40.201 1.00 38.23  ? 628  VAL A CB  1 
ATOM   2555 C  CG1 . VAL A 1 365 ? 2.425   -21.895 -40.755 1.00 39.89  ? 628  VAL A CG1 1 
ATOM   2556 C  CG2 . VAL A 1 365 ? 2.960   -24.323 -40.787 1.00 41.93  ? 628  VAL A CG2 1 
ATOM   2557 N  N   . PHE A 1 366 ? 5.682   -21.228 -38.673 1.00 40.33  ? 629  PHE A N   1 
ATOM   2558 C  CA  . PHE A 1 366 ? 6.166   -20.021 -37.958 1.00 44.08  ? 629  PHE A CA  1 
ATOM   2559 C  C   . PHE A 1 366 ? 7.499   -20.373 -37.285 1.00 53.73  ? 629  PHE A C   1 
ATOM   2560 O  O   . PHE A 1 366 ? 7.735   -21.550 -37.025 1.00 51.27  ? 629  PHE A O   1 
ATOM   2561 C  CB  . PHE A 1 366 ? 5.123   -19.519 -36.959 1.00 44.59  ? 629  PHE A CB  1 
ATOM   2562 C  CG  . PHE A 1 366 ? 4.913   -20.396 -35.752 1.00 44.84  ? 629  PHE A CG  1 
ATOM   2563 C  CD1 . PHE A 1 366 ? 5.611   -20.169 -34.578 1.00 41.01  ? 629  PHE A CD1 1 
ATOM   2564 C  CD2 . PHE A 1 366 ? 3.990   -21.432 -35.784 1.00 42.87  ? 629  PHE A CD2 1 
ATOM   2565 C  CE1 . PHE A 1 366 ? 5.401   -20.969 -33.468 1.00 48.92  ? 629  PHE A CE1 1 
ATOM   2566 C  CE2 . PHE A 1 366 ? 3.811   -22.253 -34.680 1.00 38.70  ? 629  PHE A CE2 1 
ATOM   2567 C  CZ  . PHE A 1 366 ? 4.505   -22.019 -33.525 1.00 43.61  ? 629  PHE A CZ  1 
ATOM   2568 N  N   . LYS A 1 367 ? 8.374   -19.393 -37.061 1.00 54.67  ? 630  LYS A N   1 
ATOM   2569 C  CA  . LYS A 1 367 ? 9.776   -19.644 -36.636 1.00 57.83  ? 630  LYS A CA  1 
ATOM   2570 C  C   . LYS A 1 367 ? 9.856   -19.500 -35.115 1.00 51.22  ? 630  LYS A C   1 
ATOM   2571 O  O   . LYS A 1 367 ? 10.562  -20.307 -34.474 1.00 54.77  ? 630  LYS A O   1 
ATOM   2572 C  CB  . LYS A 1 367 ? 10.700  -18.688 -37.399 1.00 72.58  ? 630  LYS A CB  1 
ATOM   2573 C  CG  . LYS A 1 367 ? 12.180  -19.062 -37.432 1.00 83.82  ? 630  LYS A CG  1 
ATOM   2574 C  CD  . LYS A 1 367 ? 12.995  -18.237 -38.432 1.00 87.95  ? 630  LYS A CD  1 
ATOM   2575 C  CE  . LYS A 1 367 ? 14.448  -18.067 -38.037 1.00 89.15  ? 630  LYS A CE  1 
ATOM   2576 N  NZ  . LYS A 1 367 ? 14.595  -17.206 -36.837 1.00 89.28  ? 630  LYS A NZ  1 
ATOM   2577 N  N   . SER A 1 368 ? 9.139   -18.538 -34.543 1.00 45.04  ? 631  SER A N   1 
ATOM   2578 C  CA  . SER A 1 368 ? 9.249   -18.180 -33.108 1.00 44.14  ? 631  SER A CA  1 
ATOM   2579 C  C   . SER A 1 368 ? 7.924   -17.680 -32.554 1.00 45.80  ? 631  SER A C   1 
ATOM   2580 O  O   . SER A 1 368 ? 7.239   -16.916 -33.258 1.00 49.55  ? 631  SER A O   1 
ATOM   2581 C  CB  . SER A 1 368 ? 10.284  -17.128 -32.884 1.00 52.19  ? 631  SER A CB  1 
ATOM   2582 O  OG  . SER A 1 368 ? 10.148  -16.558 -31.582 1.00 54.84  ? 631  SER A OG  1 
ATOM   2583 N  N   . ILE A 1 369 ? 7.673   -18.000 -31.284 1.00 44.34  ? 632  ILE A N   1 
ATOM   2584 C  CA  . ILE A 1 369 ? 6.437   -17.629 -30.536 1.00 50.05  ? 632  ILE A CA  1 
ATOM   2585 C  C   . ILE A 1 369 ? 6.570   -16.208 -29.989 1.00 51.71  ? 632  ILE A C   1 
ATOM   2586 O  O   . ILE A 1 369 ? 5.546   -15.672 -29.460 1.00 41.65  ? 632  ILE A O   1 
ATOM   2587 C  CB  . ILE A 1 369 ? 6.164   -18.614 -29.387 1.00 44.98  ? 632  ILE A CB  1 
ATOM   2588 C  CG1 . ILE A 1 369 ? 7.284   -18.618 -28.350 1.00 43.10  ? 632  ILE A CG1 1 
ATOM   2589 C  CG2 . ILE A 1 369 ? 5.893   -20.010 -29.932 1.00 49.55  ? 632  ILE A CG2 1 
ATOM   2590 C  CD1 . ILE A 1 369 ? 6.890   -19.258 -27.062 1.00 46.55  ? 632  ILE A CD1 1 
ATOM   2591 N  N   . GLN A 1 370 ? 7.797   -15.669 -30.009 1.00 55.73  ? 633  GLN A N   1 
ATOM   2592 C  CA  . GLN A 1 370 ? 8.096   -14.331 -29.436 1.00 60.36  ? 633  GLN A CA  1 
ATOM   2593 C  C   . GLN A 1 370 ? 7.228   -13.315 -30.189 1.00 53.93  ? 633  GLN A C   1 
ATOM   2594 O  O   . GLN A 1 370 ? 6.646   -12.429 -29.546 1.00 49.02  ? 633  GLN A O   1 
ATOM   2595 C  CB  . GLN A 1 370 ? 9.596   -14.031 -29.508 1.00 59.53  ? 633  GLN A CB  1 
ATOM   2596 C  CG  . GLN A 1 370 ? 10.149  -13.425 -28.219 1.00 70.70  ? 633  GLN A CG  1 
ATOM   2597 C  CD  . GLN A 1 370 ? 10.203  -14.376 -27.044 1.00 70.97  ? 633  GLN A CD  1 
ATOM   2598 O  OE1 . GLN A 1 370 ? 10.394  -15.581 -27.199 1.00 75.46  ? 633  GLN A OE1 1 
ATOM   2599 N  NE2 . GLN A 1 370 ? 10.050  -13.838 -25.842 1.00 70.68  ? 633  GLN A NE2 1 
ATOM   2600 N  N   . HIS A 1 371 ? 7.096   -13.493 -31.501 1.00 52.90  ? 634  HIS A N   1 
ATOM   2601 C  CA  . HIS A 1 371 ? 6.489   -12.493 -32.409 1.00 58.48  ? 634  HIS A CA  1 
ATOM   2602 C  C   . HIS A 1 371 ? 6.245   -13.130 -33.777 1.00 57.60  ? 634  HIS A C   1 
ATOM   2603 O  O   . HIS A 1 371 ? 7.214   -13.662 -34.375 1.00 54.76  ? 634  HIS A O   1 
ATOM   2604 C  CB  . HIS A 1 371 ? 7.414   -11.260 -32.498 1.00 67.59  ? 634  HIS A CB  1 
ATOM   2605 C  CG  . HIS A 1 371 ? 7.179   -10.408 -33.702 1.00 75.17  ? 634  HIS A CG  1 
ATOM   2606 N  ND1 . HIS A 1 371 ? 6.083   -9.558  -33.806 1.00 78.82  ? 634  HIS A ND1 1 
ATOM   2607 C  CD2 . HIS A 1 371 ? 7.874   -10.286 -34.860 1.00 77.47  ? 634  HIS A CD2 1 
ATOM   2608 C  CE1 . HIS A 1 371 ? 6.120   -8.942  -34.976 1.00 84.25  ? 634  HIS A CE1 1 
ATOM   2609 N  NE2 . HIS A 1 371 ? 7.205   -9.381  -35.647 1.00 81.05  ? 634  HIS A NE2 1 
ATOM   2610 N  N   . LEU A 1 372 ? 4.997   -13.085 -34.244 1.00 62.52  ? 635  LEU A N   1 
ATOM   2611 C  CA  . LEU A 1 372 ? 4.635   -13.404 -35.647 1.00 64.05  ? 635  LEU A CA  1 
ATOM   2612 C  C   . LEU A 1 372 ? 4.881   -12.149 -36.484 1.00 63.88  ? 635  LEU A C   1 
ATOM   2613 O  O   . LEU A 1 372 ? 4.367   -11.094 -36.093 1.00 67.89  ? 635  LEU A O   1 
ATOM   2614 C  CB  . LEU A 1 372 ? 3.173   -13.864 -35.746 1.00 65.37  ? 635  LEU A CB  1 
ATOM   2615 C  CG  . LEU A 1 372 ? 2.981   -15.306 -36.200 1.00 64.25  ? 635  LEU A CG  1 
ATOM   2616 C  CD1 . LEU A 1 372 ? 3.668   -16.258 -35.234 1.00 65.15  ? 635  LEU A CD1 1 
ATOM   2617 C  CD2 . LEU A 1 372 ? 1.504   -15.639 -36.339 1.00 65.73  ? 635  LEU A CD2 1 
ATOM   2618 N  N   . THR A 1 373 ? 5.629   -12.302 -37.577 1.00 61.67  ? 636  THR A N   1 
ATOM   2619 C  CA  . THR A 1 373 ? 5.798   -11.312 -38.664 1.00 63.47  ? 636  THR A CA  1 
ATOM   2620 C  C   . THR A 1 373 ? 4.500   -11.238 -39.461 1.00 66.27  ? 636  THR A C   1 
ATOM   2621 O  O   . THR A 1 373 ? 3.659   -12.149 -39.323 1.00 66.00  ? 636  THR A O   1 
ATOM   2622 C  CB  . THR A 1 373 ? 6.974   -11.697 -39.564 1.00 63.35  ? 636  THR A CB  1 
ATOM   2623 O  OG1 . THR A 1 373 ? 6.594   -12.878 -40.270 1.00 72.05  ? 636  THR A OG1 1 
ATOM   2624 C  CG2 . THR A 1 373 ? 8.254   -11.934 -38.789 1.00 64.34  ? 636  THR A CG2 1 
ATOM   2625 N  N   . VAL A 1 374 ? 4.359   -10.204 -40.282 1.00 63.64  ? 637  VAL A N   1 
ATOM   2626 C  CA  . VAL A 1 374 ? 3.110   -9.932  -41.050 1.00 67.40  ? 637  VAL A CA  1 
ATOM   2627 C  C   . VAL A 1 374 ? 2.876   -11.088 -42.029 1.00 67.60  ? 637  VAL A C   1 
ATOM   2628 O  O   . VAL A 1 374 ? 1.706   -11.532 -42.170 1.00 63.64  ? 637  VAL A O   1 
ATOM   2629 C  CB  . VAL A 1 374 ? 3.172   -8.566  -41.764 1.00 72.91  ? 637  VAL A CB  1 
ATOM   2630 C  CG1 . VAL A 1 374 ? 3.146   -7.425  -40.762 1.00 75.13  ? 637  VAL A CG1 1 
ATOM   2631 C  CG2 . VAL A 1 374 ? 4.377   -8.428  -42.691 1.00 75.29  ? 637  VAL A CG2 1 
ATOM   2632 N  N   . THR A 1 375 ? 3.948   -11.562 -42.668 1.00 62.20  ? 638  THR A N   1 
ATOM   2633 C  CA  . THR A 1 375 ? 3.893   -12.652 -43.675 1.00 63.88  ? 638  THR A CA  1 
ATOM   2634 C  C   . THR A 1 375 ? 3.752   -14.025 -42.981 1.00 55.92  ? 638  THR A C   1 
ATOM   2635 O  O   . THR A 1 375 ? 3.264   -14.947 -43.640 1.00 54.28  ? 638  THR A O   1 
ATOM   2636 C  CB  . THR A 1 375 ? 5.112   -12.625 -44.609 1.00 62.56  ? 638  THR A CB  1 
ATOM   2637 O  OG1 . THR A 1 375 ? 6.255   -12.855 -43.788 1.00 72.20  ? 638  THR A OG1 1 
ATOM   2638 C  CG2 . THR A 1 375 ? 5.267   -11.334 -45.390 1.00 67.02  ? 638  THR A CG2 1 
ATOM   2639 N  N   . GLU A 1 376 ? 4.223   -14.190 -41.740 1.00 56.30  ? 639  GLU A N   1 
ATOM   2640 C  CA  . GLU A 1 376 ? 3.987   -15.450 -40.978 1.00 58.49  ? 639  GLU A CA  1 
ATOM   2641 C  C   . GLU A 1 376 ? 2.476   -15.549 -40.735 1.00 57.20  ? 639  GLU A C   1 
ATOM   2642 O  O   . GLU A 1 376 ? 1.938   -16.627 -41.004 1.00 55.41  ? 639  GLU A O   1 
ATOM   2643 C  CB  . GLU A 1 376 ? 4.845   -15.544 -39.714 1.00 52.15  ? 639  GLU A CB  1 
ATOM   2644 C  CG  . GLU A 1 376 ? 6.230   -16.115 -40.001 1.00 51.84  ? 639  GLU A CG  1 
ATOM   2645 C  CD  . GLU A 1 376 ? 7.184   -16.161 -38.824 1.00 46.56  ? 639  GLU A CD  1 
ATOM   2646 O  OE1 . GLU A 1 376 ? 8.066   -17.023 -38.831 1.00 54.51  ? 639  GLU A OE1 1 
ATOM   2647 O  OE2 . GLU A 1 376 ? 7.063   -15.323 -37.912 1.00 55.51  ? 639  GLU A OE2 1 
ATOM   2648 N  N   . GLU A 1 377 ? 1.804   -14.443 -40.378 1.00 54.77  ? 640  GLU A N   1 
ATOM   2649 C  CA  . GLU A 1 377 ? 0.324   -14.425 -40.181 1.00 54.43  ? 640  GLU A CA  1 
ATOM   2650 C  C   . GLU A 1 377 ? -0.373  -14.866 -41.461 1.00 58.39  ? 640  GLU A C   1 
ATOM   2651 O  O   . GLU A 1 377 ? -1.271  -15.713 -41.372 1.00 56.21  ? 640  GLU A O   1 
ATOM   2652 C  CB  . GLU A 1 377 ? -0.239  -13.058 -39.828 1.00 54.43  ? 640  GLU A CB  1 
ATOM   2653 C  CG  . GLU A 1 377 ? 0.086   -12.645 -38.421 1.00 62.62  ? 640  GLU A CG  1 
ATOM   2654 C  CD  . GLU A 1 377 ? -0.581  -11.350 -38.008 1.00 65.36  ? 640  GLU A CD  1 
ATOM   2655 O  OE1 . GLU A 1 377 ? -1.765  -11.163 -38.375 1.00 69.18  ? 640  GLU A OE1 1 
ATOM   2656 O  OE2 . GLU A 1 377 ? 0.086   -10.543 -37.322 1.00 65.17  ? 640  GLU A OE2 1 
ATOM   2657 N  N   . ILE A 1 378 ? 0.010   -14.321 -42.612 1.00 56.03  ? 641  ILE A N   1 
ATOM   2658 C  CA  . ILE A 1 378 ? -0.617  -14.750 -43.895 1.00 55.36  ? 641  ILE A CA  1 
ATOM   2659 C  C   . ILE A 1 378 ? -0.314  -16.250 -44.088 1.00 52.43  ? 641  ILE A C   1 
ATOM   2660 O  O   . ILE A 1 378 ? -1.225  -16.969 -44.512 1.00 52.88  ? 641  ILE A O   1 
ATOM   2661 C  CB  . ILE A 1 378 ? -0.197  -13.868 -45.097 1.00 56.36  ? 641  ILE A CB  1 
ATOM   2662 C  CG1 . ILE A 1 378 ? -1.036  -14.172 -46.344 1.00 56.44  ? 641  ILE A CG1 1 
ATOM   2663 C  CG2 . ILE A 1 378 ? 1.284   -13.990 -45.354 1.00 57.75  ? 641  ILE A CG2 1 
ATOM   2664 C  CD1 . ILE A 1 378 ? -0.301  -14.091 -47.664 1.00 66.38  ? 641  ILE A CD1 1 
ATOM   2665 N  N   . ALA A 1 379 ? 0.897   -16.722 -43.774 1.00 47.91  ? 642  ALA A N   1 
ATOM   2666 C  CA  . ALA A 1 379 ? 1.288   -18.150 -43.921 1.00 48.47  ? 642  ALA A CA  1 
ATOM   2667 C  C   . ALA A 1 379 ? 0.395   -19.077 -43.042 1.00 37.56  ? 642  ALA A C   1 
ATOM   2668 O  O   . ALA A 1 379 ? -0.057  -20.109 -43.553 1.00 37.63  ? 642  ALA A O   1 
ATOM   2669 C  CB  . ALA A 1 379 ? 2.760   -18.307 -43.601 1.00 48.02  ? 642  ALA A CB  1 
ATOM   2670 N  N   . VAL A 1 380 ? 0.172   -18.704 -41.779 1.00 37.16  ? 643  VAL A N   1 
ATOM   2671 C  CA  . VAL A 1 380 ? -0.681  -19.433 -40.797 1.00 42.59  ? 643  VAL A CA  1 
ATOM   2672 C  C   . VAL A 1 380 ? -2.109  -19.492 -41.361 1.00 43.70  ? 643  VAL A C   1 
ATOM   2673 O  O   . VAL A 1 380 ? -2.677  -20.615 -41.454 1.00 36.97  ? 643  VAL A O   1 
ATOM   2674 C  CB  . VAL A 1 380 ? -0.592  -18.793 -39.398 1.00 40.96  ? 643  VAL A CB  1 
ATOM   2675 C  CG1 . VAL A 1 380 ? -1.635  -19.350 -38.452 1.00 42.40  ? 643  VAL A CG1 1 
ATOM   2676 C  CG2 . VAL A 1 380 ? 0.791   -18.977 -38.783 1.00 42.01  ? 643  VAL A CG2 1 
ATOM   2677 N  N   . LYS A 1 381 ? -2.640  -18.346 -41.816 1.00 41.89  ? 644  LYS A N   1 
ATOM   2678 C  CA  . LYS A 1 381 ? -3.999  -18.254 -42.403 1.00 43.41  ? 644  LYS A CA  1 
ATOM   2679 C  C   . LYS A 1 381 ? -4.075  -19.212 -43.595 1.00 42.02  ? 644  LYS A C   1 
ATOM   2680 O  O   . LYS A 1 381 ? -5.035  -20.018 -43.666 1.00 38.22  ? 644  LYS A O   1 
ATOM   2681 C  CB  . LYS A 1 381 ? -4.328  -16.812 -42.818 1.00 52.17  ? 644  LYS A CB  1 
ATOM   2682 C  CG  . LYS A 1 381 ? -5.002  -15.963 -41.748 1.00 62.44  ? 644  LYS A CG  1 
ATOM   2683 C  CD  . LYS A 1 381 ? -4.491  -14.514 -41.656 1.00 71.72  ? 644  LYS A CD  1 
ATOM   2684 C  CE  . LYS A 1 381 ? -5.044  -13.743 -40.472 1.00 70.50  ? 644  LYS A CE  1 
ATOM   2685 N  NZ  . LYS A 1 381 ? -4.048  -12.802 -39.904 1.00 75.68  ? 644  LYS A NZ  1 
ATOM   2686 N  N   . ASN A 1 382 ? -3.059  -19.186 -44.462 1.00 42.48  ? 645  ASN A N   1 
ATOM   2687 C  CA  . ASN A 1 382 ? -3.055  -19.946 -45.744 1.00 43.28  ? 645  ASN A CA  1 
ATOM   2688 C  C   . ASN A 1 382 ? -2.879  -21.446 -45.475 1.00 39.75  ? 645  ASN A C   1 
ATOM   2689 O  O   . ASN A 1 382 ? -3.403  -22.272 -46.251 1.00 36.04  ? 645  ASN A O   1 
ATOM   2690 C  CB  . ASN A 1 382 ? -1.962  -19.430 -46.689 1.00 52.68  ? 645  ASN A CB  1 
ATOM   2691 C  CG  . ASN A 1 382 ? -2.338  -18.122 -47.364 1.00 64.79  ? 645  ASN A CG  1 
ATOM   2692 O  OD1 . ASN A 1 382 ? -3.477  -17.934 -47.799 1.00 72.31  ? 645  ASN A OD1 1 
ATOM   2693 N  ND2 . ASN A 1 382 ? -1.380  -17.216 -47.484 1.00 71.87  ? 645  ASN A ND2 1 
ATOM   2694 N  N   . TRP A 1 383 ? -2.110  -21.797 -44.441 1.00 42.15  ? 646  TRP A N   1 
ATOM   2695 C  CA  . TRP A 1 383 ? -1.981  -23.208 -43.967 1.00 37.69  ? 646  TRP A CA  1 
ATOM   2696 C  C   . TRP A 1 383 ? -3.390  -23.719 -43.576 1.00 31.05  ? 646  TRP A C   1 
ATOM   2697 O  O   . TRP A 1 383 ? -3.848  -24.723 -44.135 1.00 34.08  ? 646  TRP A O   1 
ATOM   2698 C  CB  . TRP A 1 383 ? -0.960  -23.242 -42.826 1.00 31.77  ? 646  TRP A CB  1 
ATOM   2699 C  CG  . TRP A 1 383 ? -0.542  -24.606 -42.371 1.00 37.88  ? 646  TRP A CG  1 
ATOM   2700 C  CD1 . TRP A 1 383 ? 0.478   -25.387 -42.853 1.00 43.12  ? 646  TRP A CD1 1 
ATOM   2701 C  CD2 . TRP A 1 383 ? -1.115  -25.344 -41.282 1.00 37.82  ? 646  TRP A CD2 1 
ATOM   2702 N  NE1 . TRP A 1 383 ? 0.570   -26.561 -42.145 1.00 37.52  ? 646  TRP A NE1 1 
ATOM   2703 C  CE2 . TRP A 1 383 ? -0.382  -26.551 -41.163 1.00 38.54  ? 646  TRP A CE2 1 
ATOM   2704 C  CE3 . TRP A 1 383 ? -2.174  -25.100 -40.408 1.00 33.19  ? 646  TRP A CE3 1 
ATOM   2705 C  CZ2 . TRP A 1 383 ? -0.675  -27.494 -40.180 1.00 34.55  ? 646  TRP A CZ2 1 
ATOM   2706 C  CZ3 . TRP A 1 383 ? -2.460  -26.026 -39.429 1.00 35.56  ? 646  TRP A CZ3 1 
ATOM   2707 C  CH2 . TRP A 1 383 ? -1.729  -27.210 -39.333 1.00 34.88  ? 646  TRP A CH2 1 
ATOM   2708 N  N   . LEU A 1 384 ? -4.083  -22.966 -42.727 1.00 34.83  ? 647  LEU A N   1 
ATOM   2709 C  CA  . LEU A 1 384 ? -5.440  -23.335 -42.233 1.00 40.35  ? 647  LEU A CA  1 
ATOM   2710 C  C   . LEU A 1 384 ? -6.398  -23.545 -43.415 1.00 38.86  ? 647  LEU A C   1 
ATOM   2711 O  O   . LEU A 1 384 ? -7.023  -24.616 -43.493 1.00 37.48  ? 647  LEU A O   1 
ATOM   2712 C  CB  . LEU A 1 384 ? -5.911  -22.276 -41.233 1.00 36.80  ? 647  LEU A CB  1 
ATOM   2713 C  CG  . LEU A 1 384 ? -5.182  -22.315 -39.892 1.00 37.32  ? 647  LEU A CG  1 
ATOM   2714 C  CD1 . LEU A 1 384 ? -5.553  -21.124 -39.035 1.00 36.64  ? 647  LEU A CD1 1 
ATOM   2715 C  CD2 . LEU A 1 384 ? -5.444  -23.609 -39.111 1.00 35.68  ? 647  LEU A CD2 1 
ATOM   2716 N  N   . VAL A 1 385 ? -6.431  -22.613 -44.368 1.00 45.00  ? 648  VAL A N   1 
ATOM   2717 C  CA  . VAL A 1 385 ? -7.366  -22.656 -45.523 1.00 43.11  ? 648  VAL A CA  1 
ATOM   2718 C  C   . VAL A 1 385 ? -6.961  -23.831 -46.403 1.00 40.85  ? 648  VAL A C   1 
ATOM   2719 O  O   . VAL A 1 385 ? -7.840  -24.560 -46.827 1.00 44.13  ? 648  VAL A O   1 
ATOM   2720 C  CB  . VAL A 1 385 ? -7.360  -21.324 -46.308 1.00 49.22  ? 648  VAL A CB  1 
ATOM   2721 C  CG1 . VAL A 1 385 ? -8.142  -21.442 -47.610 1.00 48.25  ? 648  VAL A CG1 1 
ATOM   2722 C  CG2 . VAL A 1 385 ? -7.900  -20.174 -45.458 1.00 50.61  ? 648  VAL A CG2 1 
ATOM   2723 N  N   . ARG A 1 386 ? -5.664  -24.030 -46.617 1.00 37.73  ? 649  ARG A N   1 
ATOM   2724 C  CA  . ARG A 1 386 ? -5.147  -25.052 -47.556 1.00 41.50  ? 649  ARG A CA  1 
ATOM   2725 C  C   . ARG A 1 386 ? -5.221  -26.456 -46.921 1.00 41.69  ? 649  ARG A C   1 
ATOM   2726 O  O   . ARG A 1 386 ? -5.616  -27.396 -47.627 1.00 37.49  ? 649  ARG A O   1 
ATOM   2727 C  CB  . ARG A 1 386 ? -3.723  -24.633 -47.953 1.00 53.06  ? 649  ARG A CB  1 
ATOM   2728 C  CG  . ARG A 1 386 ? -3.077  -25.458 -49.059 1.00 61.32  ? 649  ARG A CG  1 
ATOM   2729 C  CD  . ARG A 1 386 ? -1.658  -24.979 -49.394 1.00 66.68  ? 649  ARG A CD  1 
ATOM   2730 N  NE  . ARG A 1 386 ? -0.603  -25.444 -48.476 1.00 64.85  ? 649  ARG A NE  1 
ATOM   2731 C  CZ  . ARG A 1 386 ? 0.024   -24.711 -47.542 1.00 59.41  ? 649  ARG A CZ  1 
ATOM   2732 N  NH1 . ARG A 1 386 ? -0.253  -23.428 -47.357 1.00 61.75  ? 649  ARG A NH1 1 
ATOM   2733 N  NH2 . ARG A 1 386 ? 0.956   -25.273 -46.799 1.00 56.15  ? 649  ARG A NH2 1 
ATOM   2734 N  N   . VAL A 1 387 ? -4.813  -26.634 -45.655 1.00 37.97  ? 650  VAL A N   1 
ATOM   2735 C  CA  . VAL A 1 387 ? -4.660  -28.030 -45.137 1.00 40.43  ? 650  VAL A CA  1 
ATOM   2736 C  C   . VAL A 1 387 ? -5.326  -28.215 -43.762 1.00 36.76  ? 650  VAL A C   1 
ATOM   2737 O  O   . VAL A 1 387 ? -5.263  -29.364 -43.288 1.00 32.74  ? 650  VAL A O   1 
ATOM   2738 C  CB  . VAL A 1 387 ? -3.182  -28.473 -45.074 1.00 33.65  ? 650  VAL A CB  1 
ATOM   2739 C  CG1 . VAL A 1 387 ? -2.555  -28.559 -46.452 1.00 38.45  ? 650  VAL A CG1 1 
ATOM   2740 C  CG2 . VAL A 1 387 ? -2.370  -27.593 -44.144 1.00 33.82  ? 650  VAL A CG2 1 
ATOM   2741 N  N   . GLY A 1 388 ? -5.944  -27.176 -43.188 1.00 32.70  ? 651  GLY A N   1 
ATOM   2742 C  CA  . GLY A 1 388 ? -6.557  -27.192 -41.840 1.00 33.76  ? 651  GLY A CA  1 
ATOM   2743 C  C   . GLY A 1 388 ? -7.470  -28.387 -41.644 1.00 32.48  ? 651  GLY A C   1 
ATOM   2744 O  O   . GLY A 1 388 ? -7.316  -29.104 -40.645 1.00 34.22  ? 651  GLY A O   1 
ATOM   2745 N  N   . ARG A 1 389 ? -8.390  -28.626 -42.568 1.00 31.88  ? 652  ARG A N   1 
ATOM   2746 C  CA  . ARG A 1 389 ? -9.381  -29.728 -42.424 1.00 35.82  ? 652  ARG A CA  1 
ATOM   2747 C  C   . ARG A 1 389 ? -8.614  -31.057 -42.481 1.00 36.49  ? 652  ARG A C   1 
ATOM   2748 O  O   . ARG A 1 389 ? -8.959  -31.966 -41.706 1.00 32.62  ? 652  ARG A O   1 
ATOM   2749 C  CB  . ARG A 1 389 ? -10.479 -29.653 -43.490 1.00 36.48  ? 652  ARG A CB  1 
ATOM   2750 C  CG  . ARG A 1 389 ? -11.422 -28.474 -43.319 1.00 38.91  ? 652  ARG A CG  1 
ATOM   2751 C  CD  . ARG A 1 389 ? -12.457 -28.446 -44.435 1.00 38.81  ? 652  ARG A CD  1 
ATOM   2752 N  NE  . ARG A 1 389 ? -13.443 -29.503 -44.294 1.00 41.02  ? 652  ARG A NE  1 
ATOM   2753 C  CZ  . ARG A 1 389 ? -14.450 -29.484 -43.412 1.00 37.65  ? 652  ARG A CZ  1 
ATOM   2754 N  NH1 . ARG A 1 389 ? -14.615 -28.475 -42.565 1.00 41.08  ? 652  ARG A NH1 1 
ATOM   2755 N  NH2 . ARG A 1 389 ? -15.268 -30.514 -43.362 1.00 38.36  ? 652  ARG A NH2 1 
ATOM   2756 N  N   . GLU A 1 390 ? -7.589  -31.187 -43.317 1.00 30.05  ? 653  GLU A N   1 
ATOM   2757 C  CA  . GLU A 1 390 ? -6.795  -32.446 -43.335 1.00 34.17  ? 653  GLU A CA  1 
ATOM   2758 C  C   . GLU A 1 390 ? -6.099  -32.673 -41.987 1.00 28.40  ? 653  GLU A C   1 
ATOM   2759 O  O   . GLU A 1 390 ? -6.096  -33.811 -41.516 1.00 28.91  ? 653  GLU A O   1 
ATOM   2760 C  CB  . GLU A 1 390 ? -5.761  -32.432 -44.461 1.00 35.73  ? 653  GLU A CB  1 
ATOM   2761 C  CG  . GLU A 1 390 ? -5.266  -33.810 -44.855 1.00 33.05  ? 653  GLU A CG  1 
ATOM   2762 C  CD  . GLU A 1 390 ? -4.142  -34.375 -44.004 1.00 35.46  ? 653  GLU A CD  1 
ATOM   2763 O  OE1 . GLU A 1 390 ? -3.504  -33.599 -43.276 1.00 34.44  ? 653  GLU A OE1 1 
ATOM   2764 O  OE2 . GLU A 1 390 ? -3.916  -35.592 -44.072 1.00 41.38  ? 653  GLU A OE2 1 
ATOM   2765 N  N   . ARG A 1 391 ? -5.538  -31.618 -41.410 1.00 26.46  ? 654  ARG A N   1 
ATOM   2766 C  CA  . ARG A 1 391 ? -4.771  -31.753 -40.147 1.00 30.25  ? 654  ARG A CA  1 
ATOM   2767 C  C   . ARG A 1 391 ? -5.718  -32.088 -38.983 1.00 27.46  ? 654  ARG A C   1 
ATOM   2768 O  O   . ARG A 1 391 ? -5.281  -32.754 -38.053 1.00 24.44  ? 654  ARG A O   1 
ATOM   2769 C  CB  . ARG A 1 391 ? -3.939  -30.485 -39.931 1.00 30.30  ? 654  ARG A CB  1 
ATOM   2770 C  CG  . ARG A 1 391 ? -2.984  -30.171 -41.072 1.00 31.33  ? 654  ARG A CG  1 
ATOM   2771 C  CD  . ARG A 1 391 ? -1.948  -31.257 -41.274 1.00 34.05  ? 654  ARG A CD  1 
ATOM   2772 N  NE  . ARG A 1 391 ? -0.826  -30.761 -42.051 1.00 34.88  ? 654  ARG A NE  1 
ATOM   2773 C  CZ  . ARG A 1 391 ? -0.685  -30.922 -43.359 1.00 40.25  ? 654  ARG A CZ  1 
ATOM   2774 N  NH1 . ARG A 1 391 ? -1.592  -31.590 -44.047 1.00 37.50  ? 654  ARG A NH1 1 
ATOM   2775 N  NH2 . ARG A 1 391 ? 0.371   -30.422 -43.973 1.00 41.17  ? 654  ARG A NH2 1 
ATOM   2776 N  N   . LEU A 1 392 ? -6.967  -31.625 -39.056 1.00 26.78  ? 655  LEU A N   1 
ATOM   2777 C  CA  . LEU A 1 392 ? -7.966  -31.947 -37.998 1.00 26.09  ? 655  LEU A CA  1 
ATOM   2778 C  C   . LEU A 1 392 ? -8.278  -33.442 -38.064 1.00 25.15  ? 655  LEU A C   1 
ATOM   2779 O  O   . LEU A 1 392 ? -8.436  -34.061 -37.020 1.00 24.06  ? 655  LEU A O   1 
ATOM   2780 C  CB  . LEU A 1 392 ? -9.241  -31.130 -38.225 1.00 28.35  ? 655  LEU A CB  1 
ATOM   2781 C  CG  . LEU A 1 392 ? -9.178  -29.643 -37.883 1.00 25.75  ? 655  LEU A CG  1 
ATOM   2782 C  CD1 . LEU A 1 392 ? -10.488 -28.964 -38.247 1.00 29.00  ? 655  LEU A CD1 1 
ATOM   2783 C  CD2 . LEU A 1 392 ? -8.872  -29.438 -36.411 1.00 26.90  ? 655  LEU A CD2 1 
ATOM   2784 N  N   . SER A 1 393 ? -8.358  -33.976 -39.275 1.00 26.61  ? 656  SER A N   1 
ATOM   2785 C  CA  . SER A 1 393 ? -8.704  -35.402 -39.482 1.00 28.86  ? 656  SER A CA  1 
ATOM   2786 C  C   . SER A 1 393 ? -7.577  -36.316 -39.003 1.00 27.45  ? 656  SER A C   1 
ATOM   2787 O  O   . SER A 1 393 ? -7.794  -37.516 -38.946 1.00 23.26  ? 656  SER A O   1 
ATOM   2788 C  CB  . SER A 1 393 ? -9.018  -35.639 -40.929 1.00 30.81  ? 656  SER A CB  1 
ATOM   2789 O  OG  . SER A 1 393 ? -7.867  -35.497 -41.740 1.00 37.84  ? 656  SER A OG  1 
ATOM   2790 N  N   . ARG A 1 394 ? -6.410  -35.739 -38.716 1.00 24.59  ? 657  ARG A N   1 
ATOM   2791 C  CA  . ARG A 1 394 ? -5.246  -36.523 -38.234 1.00 25.58  ? 657  ARG A CA  1 
ATOM   2792 C  C   . ARG A 1 394 ? -5.335  -36.645 -36.712 1.00 23.64  ? 657  ARG A C   1 
ATOM   2793 O  O   . ARG A 1 394 ? -4.377  -37.113 -36.098 1.00 22.88  ? 657  ARG A O   1 
ATOM   2794 C  CB  . ARG A 1 394 ? -3.941  -35.815 -38.606 1.00 27.89  ? 657  ARG A CB  1 
ATOM   2795 C  CG  . ARG A 1 394 ? -3.644  -35.778 -40.094 1.00 32.16  ? 657  ARG A CG  1 
ATOM   2796 C  CD  . ARG A 1 394 ? -2.313  -35.112 -40.372 1.00 29.79  ? 657  ARG A CD  1 
ATOM   2797 N  NE  . ARG A 1 394 ? -1.917  -35.486 -41.714 1.00 30.11  ? 657  ARG A NE  1 
ATOM   2798 C  CZ  . ARG A 1 394 ? -1.161  -36.532 -42.001 1.00 32.27  ? 657  ARG A CZ  1 
ATOM   2799 N  NH1 . ARG A 1 394 ? -0.686  -37.291 -41.030 1.00 31.32  ? 657  ARG A NH1 1 
ATOM   2800 N  NH2 . ARG A 1 394 ? -0.869  -36.807 -43.257 1.00 33.19  ? 657  ARG A NH2 1 
ATOM   2801 N  N   . MET A 1 395 ? -6.457  -36.201 -36.154 1.00 22.12  ? 658  MET A N   1 
ATOM   2802 C  CA  . MET A 1 395 ? -6.579  -36.208 -34.684 1.00 20.61  ? 658  MET A CA  1 
ATOM   2803 C  C   . MET A 1 395 ? -7.901  -36.779 -34.152 1.00 21.96  ? 658  MET A C   1 
ATOM   2804 O  O   . MET A 1 395 ? -8.890  -36.731 -34.864 1.00 21.31  ? 658  MET A O   1 
ATOM   2805 C  CB  . MET A 1 395 ? -6.408  -34.785 -34.142 1.00 23.21  ? 658  MET A CB  1 
ATOM   2806 C  CG  . MET A 1 395 ? -5.195  -34.055 -34.692 1.00 24.36  ? 658  MET A CG  1 
ATOM   2807 S  SD  . MET A 1 395 ? -4.860  -32.475 -33.870 1.00 25.29  ? 658  MET A SD  1 
ATOM   2808 C  CE  . MET A 1 395 ? -6.236  -31.485 -34.446 1.00 26.24  ? 658  MET A CE  1 
ATOM   2809 N  N   . ALA A 1 396 ? -7.852  -37.354 -32.957 1.00 20.93  ? 659  ALA A N   1 
ATOM   2810 C  CA  . ALA A 1 396 ? -9.012  -37.795 -32.160 1.00 21.83  ? 659  ALA A CA  1 
ATOM   2811 C  C   . ALA A 1 396 ? -8.919  -37.083 -30.806 1.00 21.61  ? 659  ALA A C   1 
ATOM   2812 O  O   . ALA A 1 396 ? -7.956  -37.243 -30.105 1.00 20.40  ? 659  ALA A O   1 
ATOM   2813 C  CB  . ALA A 1 396 ? -9.025  -39.297 -32.026 1.00 22.02  ? 659  ALA A CB  1 
ATOM   2814 N  N   . ILE A 1 397 ? -9.879  -36.212 -30.520 1.00 20.44  ? 660  ILE A N   1 
ATOM   2815 C  CA  . ILE A 1 397 ? -9.836  -35.285 -29.383 1.00 20.39  ? 660  ILE A CA  1 
ATOM   2816 C  C   . ILE A 1 397 ? -11.170 -35.372 -28.634 1.00 24.54  ? 660  ILE A C   1 
ATOM   2817 O  O   . ILE A 1 397 ? -12.245 -35.105 -29.205 1.00 22.49  ? 660  ILE A O   1 
ATOM   2818 C  CB  . ILE A 1 397 ? -9.529  -33.868 -29.876 1.00 22.52  ? 660  ILE A CB  1 
ATOM   2819 C  CG1 . ILE A 1 397 ? -8.201  -33.854 -30.644 1.00 26.88  ? 660  ILE A CG1 1 
ATOM   2820 C  CG2 . ILE A 1 397 ? -9.584  -32.937 -28.688 1.00 22.58  ? 660  ILE A CG2 1 
ATOM   2821 C  CD1 . ILE A 1 397 ? -7.626  -32.496 -30.975 1.00 27.82  ? 660  ILE A CD1 1 
ATOM   2822 N  N   . SER A 1 398 ? -11.055 -35.719 -27.363 1.00 23.91  ? 661  SER A N   1 
ATOM   2823 C  CA  . SER A 1 398 ? -12.178 -35.849 -26.431 1.00 26.70  ? 661  SER A CA  1 
ATOM   2824 C  C   . SER A 1 398 ? -11.860 -34.977 -25.240 1.00 25.53  ? 661  SER A C   1 
ATOM   2825 O  O   . SER A 1 398 ? -11.126 -35.437 -24.358 1.00 23.83  ? 661  SER A O   1 
ATOM   2826 C  CB  . SER A 1 398 ? -12.402 -37.292 -26.036 1.00 27.12  ? 661  SER A CB  1 
ATOM   2827 O  OG  . SER A 1 398 ? -13.664 -37.400 -25.453 1.00 25.80  ? 661  SER A OG  1 
ATOM   2828 N  N   . GLY A 1 399 ? -12.349 -33.739 -25.246 1.00 22.35  ? 662  GLY A N   1 
ATOM   2829 C  CA  . GLY A 1 399 ? -11.978 -32.801 -24.171 1.00 23.21  ? 662  GLY A CA  1 
ATOM   2830 C  C   . GLY A 1 399 ? -10.469 -32.626 -24.041 1.00 24.03  ? 662  GLY A C   1 
ATOM   2831 O  O   . GLY A 1 399 ? -9.796  -32.320 -25.063 1.00 23.84  ? 662  GLY A O   1 
ATOM   2832 N  N   . ASP A 1 400 ? -9.912  -32.838 -22.847 1.00 22.95  ? 663  ASP A N   1 
ATOM   2833 C  CA  . ASP A 1 400 ? -8.443  -32.692 -22.644 1.00 25.73  ? 663  ASP A CA  1 
ATOM   2834 C  C   . ASP A 1 400 ? -7.655  -33.878 -23.202 1.00 24.70  ? 663  ASP A C   1 
ATOM   2835 O  O   . ASP A 1 400 ? -6.408  -33.800 -23.198 1.00 24.31  ? 663  ASP A O   1 
ATOM   2836 C  CB  . ASP A 1 400 ? -8.119  -32.425 -21.178 1.00 31.64  ? 663  ASP A CB  1 
ATOM   2837 C  CG  . ASP A 1 400 ? -8.442  -33.571 -20.228 1.00 37.06  ? 663  ASP A CG  1 
ATOM   2838 O  OD1 . ASP A 1 400 ? -9.114  -34.500 -20.621 1.00 38.28  ? 663  ASP A OD1 1 
ATOM   2839 O  OD2 . ASP A 1 400 ? -8.019  -33.495 -19.106 1.00 40.64  ? 663  ASP A OD2 1 
ATOM   2840 N  N   . ASP A 1 401 ? -8.307  -34.896 -23.742 1.00 24.35  ? 664  ASP A N   1 
ATOM   2841 C  CA  . ASP A 1 401 ? -7.628  -36.135 -24.202 1.00 23.39  ? 664  ASP A CA  1 
ATOM   2842 C  C   . ASP A 1 401 ? -7.435  -36.059 -25.708 1.00 24.12  ? 664  ASP A C   1 
ATOM   2843 O  O   . ASP A 1 401 ? -8.397  -35.705 -26.408 1.00 27.77  ? 664  ASP A O   1 
ATOM   2844 C  CB  . ASP A 1 401 ? -8.459  -37.354 -23.785 1.00 25.56  ? 664  ASP A CB  1 
ATOM   2845 C  CG  . ASP A 1 401 ? -7.632  -38.611 -23.702 1.00 31.41  ? 664  ASP A CG  1 
ATOM   2846 O  OD1 . ASP A 1 401 ? -6.457  -38.483 -23.949 1.00 32.43  ? 664  ASP A OD1 1 
ATOM   2847 O  OD2 . ASP A 1 401 ? -8.171  -39.646 -23.415 1.00 32.68  ? 664  ASP A OD2 1 
ATOM   2848 N  N   . CYS A 1 402 ? -6.214  -36.273 -26.207 1.00 22.53  ? 665  CYS A N   1 
ATOM   2849 C  CA  . CYS A 1 402 ? -5.944  -36.240 -27.649 1.00 23.02  ? 665  CYS A CA  1 
ATOM   2850 C  C   . CYS A 1 402 ? -5.072  -37.397 -28.113 1.00 22.87  ? 665  CYS A C   1 
ATOM   2851 O  O   . CYS A 1 402 ? -4.185  -37.881 -27.338 1.00 25.17  ? 665  CYS A O   1 
ATOM   2852 C  CB  . CYS A 1 402 ? -5.314  -34.922 -28.063 1.00 27.72  ? 665  CYS A CB  1 
ATOM   2853 S  SG  . CYS A 1 402 ? -3.671  -34.643 -27.355 1.00 32.77  ? 665  CYS A SG  1 
ATOM   2854 N  N   . VAL A 1 403 ? -5.235  -37.705 -29.399 1.00 22.49  ? 666  VAL A N   1 
ATOM   2855 C  CA  . VAL A 1 403 ? -4.326  -38.575 -30.197 1.00 24.96  ? 666  VAL A CA  1 
ATOM   2856 C  C   . VAL A 1 403 ? -4.104  -37.809 -31.500 1.00 25.62  ? 666  VAL A C   1 
ATOM   2857 O  O   . VAL A 1 403 ? -5.091  -37.293 -32.084 1.00 23.28  ? 666  VAL A O   1 
ATOM   2858 C  CB  . VAL A 1 403 ? -4.887  -39.992 -30.431 1.00 23.86  ? 666  VAL A CB  1 
ATOM   2859 C  CG1 . VAL A 1 403 ? -3.983  -40.843 -31.324 1.00 26.13  ? 666  VAL A CG1 1 
ATOM   2860 C  CG2 . VAL A 1 403 ? -5.209  -40.666 -29.095 1.00 22.83  ? 666  VAL A CG2 1 
ATOM   2861 N  N   . VAL A 1 404 ? -2.847  -37.644 -31.872 1.00 21.91  ? 667  VAL A N   1 
ATOM   2862 C  CA  . VAL A 1 404 ? -2.439  -36.856 -33.066 1.00 22.42  ? 667  VAL A CA  1 
ATOM   2863 C  C   . VAL A 1 404 ? -1.508  -37.719 -33.905 1.00 22.33  ? 667  VAL A C   1 
ATOM   2864 O  O   . VAL A 1 404 ? -0.502  -38.234 -33.362 1.00 24.20  ? 667  VAL A O   1 
ATOM   2865 C  CB  . VAL A 1 404 ? -1.750  -35.525 -32.688 1.00 25.04  ? 667  VAL A CB  1 
ATOM   2866 C  CG1 . VAL A 1 404 ? -1.345  -34.746 -33.940 1.00 23.06  ? 667  VAL A CG1 1 
ATOM   2867 C  CG2 . VAL A 1 404 ? -2.597  -34.629 -31.778 1.00 27.22  ? 667  VAL A CG2 1 
ATOM   2868 N  N   . LYS A 1 405 ? -1.821  -37.900 -35.174 1.00 23.77  ? 668  LYS A N   1 
ATOM   2869 C  CA  . LYS A 1 405 ? -0.854  -38.476 -36.134 1.00 23.87  ? 668  LYS A CA  1 
ATOM   2870 C  C   . LYS A 1 405 ? -0.368  -37.359 -37.066 1.00 26.75  ? 668  LYS A C   1 
ATOM   2871 O  O   . LYS A 1 405 ? -0.941  -37.142 -38.127 1.00 25.35  ? 668  LYS A O   1 
ATOM   2872 C  CB  . LYS A 1 405 ? -1.385  -39.634 -36.960 1.00 24.69  ? 668  LYS A CB  1 
ATOM   2873 C  CG  . LYS A 1 405 ? -0.255  -40.348 -37.683 1.00 27.61  ? 668  LYS A CG  1 
ATOM   2874 C  CD  . LYS A 1 405 ? -0.564  -41.676 -38.320 1.00 30.79  ? 668  LYS A CD  1 
ATOM   2875 C  CE  . LYS A 1 405 ? 0.735   -42.210 -38.909 1.00 32.76  ? 668  LYS A CE  1 
ATOM   2876 N  NZ  . LYS A 1 405 ? 0.509   -43.401 -39.725 1.00 36.13  ? 668  LYS A NZ  1 
ATOM   2877 N  N   . PRO A 1 406 ? 0.734   -36.671 -36.692 1.00 26.87  ? 669  PRO A N   1 
ATOM   2878 C  CA  . PRO A 1 406 ? 1.261   -35.557 -37.491 1.00 25.94  ? 669  PRO A CA  1 
ATOM   2879 C  C   . PRO A 1 406 ? 1.889   -36.040 -38.796 1.00 25.18  ? 669  PRO A C   1 
ATOM   2880 O  O   . PRO A 1 406 ? 2.114   -37.248 -39.029 1.00 26.97  ? 669  PRO A O   1 
ATOM   2881 C  CB  . PRO A 1 406 ? 2.265   -34.922 -36.536 1.00 25.08  ? 669  PRO A CB  1 
ATOM   2882 C  CG  . PRO A 1 406 ? 2.816   -36.126 -35.798 1.00 27.23  ? 669  PRO A CG  1 
ATOM   2883 C  CD  . PRO A 1 406 ? 1.572   -36.953 -35.523 1.00 23.62  ? 669  PRO A CD  1 
ATOM   2884 N  N   . LEU A 1 407 ? 2.222   -35.062 -39.624 1.00 30.01  ? 670  LEU A N   1 
ATOM   2885 C  CA  . LEU A 1 407 ? 2.872   -35.276 -40.940 1.00 31.72  ? 670  LEU A CA  1 
ATOM   2886 C  C   . LEU A 1 407 ? 4.179   -36.064 -40.751 1.00 28.97  ? 670  LEU A C   1 
ATOM   2887 O  O   . LEU A 1 407 ? 4.460   -36.911 -41.587 1.00 29.93  ? 670  LEU A O   1 
ATOM   2888 C  CB  . LEU A 1 407 ? 3.119   -33.895 -41.559 1.00 33.39  ? 670  LEU A CB  1 
ATOM   2889 C  CG  . LEU A 1 407 ? 3.049   -33.834 -43.072 1.00 40.89  ? 670  LEU A CG  1 
ATOM   2890 C  CD1 . LEU A 1 407 ? 1.659   -34.172 -43.564 1.00 40.70  ? 670  LEU A CD1 1 
ATOM   2891 C  CD2 . LEU A 1 407 ? 3.486   -32.451 -43.559 1.00 43.20  ? 670  LEU A CD2 1 
ATOM   2892 N  N   . ASP A 1 408 ? 4.907   -35.841 -39.670 1.00 29.15  ? 671  ASP A N   1 
ATOM   2893 C  CA  . ASP A 1 408 ? 6.202   -36.532 -39.413 1.00 30.61  ? 671  ASP A CA  1 
ATOM   2894 C  C   . ASP A 1 408 ? 6.571   -36.345 -37.958 1.00 29.27  ? 671  ASP A C   1 
ATOM   2895 O  O   . ASP A 1 408 ? 5.820   -35.690 -37.260 1.00 34.30  ? 671  ASP A O   1 
ATOM   2896 C  CB  . ASP A 1 408 ? 7.280   -36.011 -40.382 1.00 32.90  ? 671  ASP A CB  1 
ATOM   2897 C  CG  . ASP A 1 408 ? 7.345   -34.503 -40.379 1.00 29.58  ? 671  ASP A CG  1 
ATOM   2898 O  OD1 . ASP A 1 408 ? 7.656   -33.948 -39.314 1.00 31.85  ? 671  ASP A OD1 1 
ATOM   2899 O  OD2 . ASP A 1 408 ? 6.964   -33.889 -41.396 1.00 32.05  ? 671  ASP A OD2 1 
ATOM   2900 N  N   . ASP A 1 409 ? 7.758   -36.802 -37.534 1.00 26.87  ? 672  ASP A N   1 
ATOM   2901 C  CA  . ASP A 1 409 ? 8.114   -36.789 -36.098 1.00 28.28  ? 672  ASP A CA  1 
ATOM   2902 C  C   . ASP A 1 409 ? 8.778   -35.477 -35.661 1.00 26.79  ? 672  ASP A C   1 
ATOM   2903 O  O   . ASP A 1 409 ? 9.093   -35.355 -34.471 1.00 26.34  ? 672  ASP A O   1 
ATOM   2904 C  CB  . ASP A 1 409 ? 8.864   -38.072 -35.767 1.00 29.47  ? 672  ASP A CB  1 
ATOM   2905 C  CG  . ASP A 1 409 ? 7.990   -39.302 -35.930 1.00 35.03  ? 672  ASP A CG  1 
ATOM   2906 O  OD1 . ASP A 1 409 ? 6.832   -39.292 -35.413 1.00 33.06  ? 672  ASP A OD1 1 
ATOM   2907 O  OD2 . ASP A 1 409 ? 8.446   -40.227 -36.589 1.00 35.96  ? 672  ASP A OD2 1 
ATOM   2908 N  N   . ARG A 1 410 ? 8.866   -34.445 -36.502 1.00 30.46  ? 673  ARG A N   1 
ATOM   2909 C  CA  . ARG A 1 410 ? 9.312   -33.117 -35.989 1.00 31.06  ? 673  ARG A CA  1 
ATOM   2910 C  C   . ARG A 1 410 ? 8.361   -32.655 -34.892 1.00 28.06  ? 673  ARG A C   1 
ATOM   2911 O  O   . ARG A 1 410 ? 8.754   -31.873 -34.032 1.00 27.56  ? 673  ARG A O   1 
ATOM   2912 C  CB  . ARG A 1 410 ? 9.347   -32.057 -37.096 1.00 35.36  ? 673  ARG A CB  1 
ATOM   2913 C  CG  . ARG A 1 410 ? 10.396  -32.305 -38.173 1.00 36.44  ? 673  ARG A CG  1 
ATOM   2914 C  CD  . ARG A 1 410 ? 10.226  -31.312 -39.303 1.00 34.74  ? 673  ARG A CD  1 
ATOM   2915 N  NE  . ARG A 1 410 ? 9.033   -31.589 -40.101 1.00 34.54  ? 673  ARG A NE  1 
ATOM   2916 C  CZ  . ARG A 1 410 ? 8.517   -30.765 -41.017 1.00 38.68  ? 673  ARG A CZ  1 
ATOM   2917 N  NH1 . ARG A 1 410 ? 9.075   -29.579 -41.230 1.00 35.36  ? 673  ARG A NH1 1 
ATOM   2918 N  NH2 . ARG A 1 410 ? 7.439   -31.127 -41.704 1.00 36.58  ? 673  ARG A NH2 1 
ATOM   2919 N  N   . PHE A 1 411 ? 7.087   -33.079 -34.946 1.00 27.98  ? 674  PHE A N   1 
ATOM   2920 C  CA  . PHE A 1 411 ? 6.050   -32.788 -33.923 1.00 25.60  ? 674  PHE A CA  1 
ATOM   2921 C  C   . PHE A 1 411 ? 6.546   -33.131 -32.518 1.00 25.19  ? 674  PHE A C   1 
ATOM   2922 O  O   . PHE A 1 411 ? 6.258   -32.351 -31.575 1.00 27.90  ? 674  PHE A O   1 
ATOM   2923 C  CB  . PHE A 1 411 ? 4.773   -33.590 -34.258 1.00 26.84  ? 674  PHE A CB  1 
ATOM   2924 C  CG  . PHE A 1 411 ? 3.604   -33.400 -33.317 1.00 24.72  ? 674  PHE A CG  1 
ATOM   2925 C  CD1 . PHE A 1 411 ? 3.441   -34.222 -32.201 1.00 24.64  ? 674  PHE A CD1 1 
ATOM   2926 C  CD2 . PHE A 1 411 ? 2.602   -32.501 -33.624 1.00 26.92  ? 674  PHE A CD2 1 
ATOM   2927 C  CE1 . PHE A 1 411 ? 2.322   -34.082 -31.381 1.00 26.60  ? 674  PHE A CE1 1 
ATOM   2928 C  CE2 . PHE A 1 411 ? 1.477   -32.371 -32.816 1.00 26.73  ? 674  PHE A CE2 1 
ATOM   2929 C  CZ  . PHE A 1 411 ? 1.357   -33.132 -31.672 1.00 24.15  ? 674  PHE A CZ  1 
ATOM   2930 N  N   . ALA A 1 412 ? 7.311   -34.228 -32.366 1.00 26.88  ? 675  ALA A N   1 
ATOM   2931 C  CA  . ALA A 1 412 ? 7.796   -34.733 -31.067 1.00 26.02  ? 675  ALA A CA  1 
ATOM   2932 C  C   . ALA A 1 412 ? 8.565   -33.662 -30.284 1.00 28.15  ? 675  ALA A C   1 
ATOM   2933 O  O   . ALA A 1 412 ? 8.382   -33.578 -29.037 1.00 25.15  ? 675  ALA A O   1 
ATOM   2934 C  CB  . ALA A 1 412 ? 8.634   -35.975 -31.273 1.00 29.26  ? 675  ALA A CB  1 
ATOM   2935 N  N   . SER A 1 413 ? 9.373   -32.837 -30.961 1.00 29.31  ? 676  SER A N   1 
ATOM   2936 C  CA  . SER A 1 413 ? 10.202  -31.809 -30.280 1.00 29.56  ? 676  SER A CA  1 
ATOM   2937 C  C   . SER A 1 413 ? 9.643   -30.411 -30.522 1.00 35.26  ? 676  SER A C   1 
ATOM   2938 O  O   . SER A 1 413 ? 10.339  -29.459 -30.174 1.00 34.91  ? 676  SER A O   1 
ATOM   2939 C  CB  . SER A 1 413 ? 11.684  -31.915 -30.684 1.00 32.27  ? 676  SER A CB  1 
ATOM   2940 O  OG  . SER A 1 413 ? 11.791  -32.035 -32.098 1.00 36.98  ? 676  SER A OG  1 
ATOM   2941 N  N   . ALA A 1 414 ? 8.403   -30.269 -31.012 1.00 32.60  ? 677  ALA A N   1 
ATOM   2942 C  CA  . ALA A 1 414 ? 7.781   -28.945 -31.269 1.00 32.12  ? 677  ALA A CA  1 
ATOM   2943 C  C   . ALA A 1 414 ? 7.007   -28.541 -30.021 1.00 34.71  ? 677  ALA A C   1 
ATOM   2944 O  O   . ALA A 1 414 ? 5.778   -28.908 -29.894 1.00 33.14  ? 677  ALA A O   1 
ATOM   2945 C  CB  . ALA A 1 414 ? 6.928   -29.008 -32.516 1.00 33.30  ? 677  ALA A CB  1 
ATOM   2946 N  N   . LEU A 1 415 ? 7.690   -27.911 -29.067 1.00 30.67  ? 678  LEU A N   1 
ATOM   2947 C  CA  . LEU A 1 415 ? 7.203   -27.789 -27.674 1.00 30.23  ? 678  LEU A CA  1 
ATOM   2948 C  C   . LEU A 1 415 ? 7.043   -26.328 -27.234 1.00 32.71  ? 678  LEU A C   1 
ATOM   2949 O  O   . LEU A 1 415 ? 6.462   -26.111 -26.158 1.00 34.36  ? 678  LEU A O   1 
ATOM   2950 C  CB  . LEU A 1 415 ? 8.130   -28.557 -26.729 1.00 31.68  ? 678  LEU A CB  1 
ATOM   2951 C  CG  . LEU A 1 415 ? 8.186   -30.082 -26.934 1.00 33.22  ? 678  LEU A CG  1 
ATOM   2952 C  CD1 . LEU A 1 415 ? 9.314   -30.711 -26.120 1.00 34.46  ? 678  LEU A CD1 1 
ATOM   2953 C  CD2 . LEU A 1 415 ? 6.851   -30.740 -26.588 1.00 33.82  ? 678  LEU A CD2 1 
ATOM   2954 N  N   . THR A 1 416 ? 7.480   -25.337 -28.011 1.00 35.35  ? 679  THR A N   1 
ATOM   2955 C  CA  . THR A 1 416 ? 7.545   -23.949 -27.479 1.00 35.25  ? 679  THR A CA  1 
ATOM   2956 C  C   . THR A 1 416 ? 6.123   -23.381 -27.342 1.00 29.44  ? 679  THR A C   1 
ATOM   2957 O  O   . THR A 1 416 ? 5.793   -22.872 -26.239 1.00 34.33  ? 679  THR A O   1 
ATOM   2958 C  CB  . THR A 1 416 ? 8.480   -23.061 -28.310 1.00 35.73  ? 679  THR A CB  1 
ATOM   2959 O  OG1 . THR A 1 416 ? 7.985   -22.886 -29.640 1.00 38.03  ? 679  THR A OG1 1 
ATOM   2960 C  CG2 . THR A 1 416 ? 9.884   -23.633 -28.402 1.00 37.36  ? 679  THR A CG2 1 
ATOM   2961 N  N   . ALA A 1 417 ? 5.307   -23.463 -28.392 1.00 32.59  ? 680  ALA A N   1 
ATOM   2962 C  CA  . ALA A 1 417 ? 3.896   -22.975 -28.354 1.00 31.29  ? 680  ALA A CA  1 
ATOM   2963 C  C   . ALA A 1 417 ? 3.121   -23.748 -27.273 1.00 35.19  ? 680  ALA A C   1 
ATOM   2964 O  O   . ALA A 1 417 ? 2.457   -23.093 -26.397 1.00 33.36  ? 680  ALA A O   1 
ATOM   2965 C  CB  . ALA A 1 417 ? 3.280   -23.049 -29.726 1.00 32.31  ? 680  ALA A CB  1 
ATOM   2966 N  N   . LEU A 1 418 ? 3.257   -25.090 -27.249 1.00 33.63  ? 681  LEU A N   1 
ATOM   2967 C  CA  . LEU A 1 418 ? 2.482   -25.934 -26.309 1.00 29.97  ? 681  LEU A CA  1 
ATOM   2968 C  C   . LEU A 1 418 ? 2.801   -25.527 -24.873 1.00 31.40  ? 681  LEU A C   1 
ATOM   2969 O  O   . LEU A 1 418 ? 1.867   -25.385 -24.085 1.00 32.11  ? 681  LEU A O   1 
ATOM   2970 C  CB  . LEU A 1 418 ? 2.805   -27.407 -26.577 1.00 31.51  ? 681  LEU A CB  1 
ATOM   2971 C  CG  . LEU A 1 418 ? 1.990   -28.407 -25.765 1.00 33.95  ? 681  LEU A CG  1 
ATOM   2972 C  CD1 . LEU A 1 418 ? 0.582   -28.506 -26.325 1.00 33.38  ? 681  LEU A CD1 1 
ATOM   2973 C  CD2 . LEU A 1 418 ? 2.683   -29.766 -25.766 1.00 33.10  ? 681  LEU A CD2 1 
ATOM   2974 N  N   . ASN A 1 419 ? 4.099   -25.365 -24.523 1.00 33.72  ? 682  ASN A N   1 
ATOM   2975 C  CA  . ASN A 1 419 ? 4.499   -24.961 -23.155 1.00 32.37  ? 682  ASN A CA  1 
ATOM   2976 C  C   . ASN A 1 419 ? 4.049   -23.509 -22.927 1.00 30.96  ? 682  ASN A C   1 
ATOM   2977 O  O   . ASN A 1 419 ? 3.496   -23.255 -21.851 1.00 32.83  ? 682  ASN A O   1 
ATOM   2978 C  CB  . ASN A 1 419 ? 6.001   -25.167 -22.908 1.00 36.48  ? 682  ASN A CB  1 
ATOM   2979 C  CG  . ASN A 1 419 ? 6.378   -26.623 -22.674 1.00 37.17  ? 682  ASN A CG  1 
ATOM   2980 O  OD1 . ASN A 1 419 ? 5.615   -27.389 -22.070 1.00 35.25  ? 682  ASN A OD1 1 
ATOM   2981 N  ND2 . ASN A 1 419 ? 7.555   -27.016 -23.133 1.00 34.76  ? 682  ASN A ND2 1 
ATOM   2982 N  N   . ASP A 1 420 ? 4.183   -22.622 -23.914 1.00 31.87  ? 683  ASP A N   1 
ATOM   2983 C  CA  . ASP A 1 420 ? 3.876   -21.171 -23.716 1.00 37.69  ? 683  ASP A CA  1 
ATOM   2984 C  C   . ASP A 1 420 ? 2.348   -20.969 -23.583 1.00 37.39  ? 683  ASP A C   1 
ATOM   2985 O  O   . ASP A 1 420 ? 1.940   -20.072 -22.865 1.00 34.39  ? 683  ASP A O   1 
ATOM   2986 C  CB  . ASP A 1 420 ? 4.399   -20.267 -24.838 1.00 38.30  ? 683  ASP A CB  1 
ATOM   2987 C  CG  . ASP A 1 420 ? 4.354   -18.782 -24.461 1.00 39.82  ? 683  ASP A CG  1 
ATOM   2988 O  OD1 . ASP A 1 420 ? 4.681   -18.479 -23.299 1.00 37.63  ? 683  ASP A OD1 1 
ATOM   2989 O  OD2 . ASP A 1 420 ? 3.943   -17.957 -25.316 1.00 39.69  ? 683  ASP A OD2 1 
ATOM   2990 N  N   . MET A 1 421 ? 1.529   -21.823 -24.201 1.00 35.82  ? 684  MET A N   1 
ATOM   2991 C  CA  . MET A 1 421 ? 0.052   -21.776 -24.023 1.00 34.51  ? 684  MET A CA  1 
ATOM   2992 C  C   . MET A 1 421 ? -0.323  -22.261 -22.620 1.00 35.36  ? 684  MET A C   1 
ATOM   2993 O  O   . MET A 1 421 ? -1.491  -22.124 -22.269 1.00 36.59  ? 684  MET A O   1 
ATOM   2994 C  CB  . MET A 1 421 ? -0.665  -22.595 -25.099 1.00 35.59  ? 684  MET A CB  1 
ATOM   2995 C  CG  . MET A 1 421 ? -0.534  -22.003 -26.477 1.00 34.23  ? 684  MET A CG  1 
ATOM   2996 S  SD  . MET A 1 421 ? -1.412  -22.951 -27.791 1.00 40.45  ? 684  MET A SD  1 
ATOM   2997 C  CE  . MET A 1 421 ? -0.425  -24.427 -27.990 1.00 42.91  ? 684  MET A CE  1 
ATOM   2998 N  N   . GLY A 1 422 ? 0.627   -22.826 -21.864 1.00 35.24  ? 685  GLY A N   1 
ATOM   2999 C  CA  . GLY A 1 422 ? 0.445   -23.403 -20.517 1.00 30.13  ? 685  GLY A CA  1 
ATOM   3000 C  C   . GLY A 1 422 ? -0.032  -24.848 -20.495 1.00 29.10  ? 685  GLY A C   1 
ATOM   3001 O  O   . GLY A 1 422 ? -0.322  -25.361 -19.368 1.00 31.81  ? 685  GLY A O   1 
ATOM   3002 N  N   . LYS A 1 423 ? -0.120  -25.510 -21.644 1.00 27.90  ? 686  LYS A N   1 
ATOM   3003 C  CA  . LYS A 1 423 ? -0.552  -26.941 -21.765 1.00 31.59  ? 686  LYS A CA  1 
ATOM   3004 C  C   . LYS A 1 423 ? 0.667   -27.876 -21.603 1.00 31.19  ? 686  LYS A C   1 
ATOM   3005 O  O   . LYS A 1 423 ? 0.989   -28.668 -22.541 1.00 32.46  ? 686  LYS A O   1 
ATOM   3006 C  CB  . LYS A 1 423 ? -1.336  -27.118 -23.069 1.00 30.33  ? 686  LYS A CB  1 
ATOM   3007 C  CG  . LYS A 1 423 ? -2.475  -26.107 -23.246 1.00 30.48  ? 686  LYS A CG  1 
ATOM   3008 C  CD  . LYS A 1 423 ? -3.424  -26.095 -22.065 1.00 34.64  ? 686  LYS A CD  1 
ATOM   3009 C  CE  . LYS A 1 423 ? -4.569  -25.106 -22.152 1.00 38.61  ? 686  LYS A CE  1 
ATOM   3010 N  NZ  . LYS A 1 423 ? -4.101  -23.699 -22.031 1.00 40.34  ? 686  LYS A NZ  1 
ATOM   3011 N  N   . VAL A 1 424 ? 1.278   -27.805 -20.421 1.00 34.66  ? 687  VAL A N   1 
ATOM   3012 C  CA  . VAL A 1 424 ? 2.501   -28.561 -20.003 1.00 34.26  ? 687  VAL A CA  1 
ATOM   3013 C  C   . VAL A 1 424 ? 2.111   -30.044 -19.899 1.00 28.93  ? 687  VAL A C   1 
ATOM   3014 O  O   . VAL A 1 424 ? 1.045   -30.374 -19.263 1.00 33.26  ? 687  VAL A O   1 
ATOM   3015 C  CB  . VAL A 1 424 ? 3.056   -27.995 -18.668 1.00 40.77  ? 687  VAL A CB  1 
ATOM   3016 C  CG1 . VAL A 1 424 ? 4.201   -28.813 -18.088 1.00 44.98  ? 687  VAL A CG1 1 
ATOM   3017 C  CG2 . VAL A 1 424 ? 3.503   -26.541 -18.800 1.00 42.58  ? 687  VAL A CG2 1 
ATOM   3018 N  N   . ARG A 1 425 ? 2.935   -30.900 -20.486 1.00 29.05  ? 688  ARG A N   1 
ATOM   3019 C  CA  . ARG A 1 425 ? 2.701   -32.356 -20.595 1.00 30.67  ? 688  ARG A CA  1 
ATOM   3020 C  C   . ARG A 1 425 ? 2.951   -32.965 -19.227 1.00 32.94  ? 688  ARG A C   1 
ATOM   3021 O  O   . ARG A 1 425 ? 3.894   -32.488 -18.556 1.00 37.42  ? 688  ARG A O   1 
ATOM   3022 C  CB  . ARG A 1 425 ? 3.581   -33.007 -21.662 1.00 29.87  ? 688  ARG A CB  1 
ATOM   3023 C  CG  . ARG A 1 425 ? 3.267   -32.566 -23.081 1.00 31.08  ? 688  ARG A CG  1 
ATOM   3024 C  CD  . ARG A 1 425 ? 4.403   -32.860 -24.032 1.00 31.96  ? 688  ARG A CD  1 
ATOM   3025 N  NE  . ARG A 1 425 ? 5.665   -32.298 -23.536 1.00 34.47  ? 688  ARG A NE  1 
ATOM   3026 C  CZ  . ARG A 1 425 ? 6.903   -32.745 -23.809 1.00 32.46  ? 688  ARG A CZ  1 
ATOM   3027 N  NH1 . ARG A 1 425 ? 7.107   -33.782 -24.599 1.00 30.94  ? 688  ARG A NH1 1 
ATOM   3028 N  NH2 . ARG A 1 425 ? 7.941   -32.135 -23.251 1.00 34.46  ? 688  ARG A NH2 1 
ATOM   3029 N  N   . LYS A 1 426 ? 2.140   -33.964 -18.861 1.00 32.08  ? 689  LYS A N   1 
ATOM   3030 C  CA  . LYS A 1 426 ? 2.246   -34.777 -17.620 1.00 38.35  ? 689  LYS A CA  1 
ATOM   3031 C  C   . LYS A 1 426 ? 3.393   -35.816 -17.745 1.00 41.34  ? 689  LYS A C   1 
ATOM   3032 O  O   . LYS A 1 426 ? 3.544   -36.402 -18.793 1.00 40.44  ? 689  LYS A O   1 
ATOM   3033 C  CB  . LYS A 1 426 ? 0.924   -35.519 -17.426 1.00 42.93  ? 689  LYS A CB  1 
ATOM   3034 C  CG  . LYS A 1 426 ? 0.700   -36.101 -16.041 1.00 49.23  ? 689  LYS A CG  1 
ATOM   3035 C  CD  . LYS A 1 426 ? -0.642  -36.751 -15.879 1.00 53.26  ? 689  LYS A CD  1 
ATOM   3036 C  CE  . LYS A 1 426 ? -0.794  -37.960 -16.772 1.00 65.61  ? 689  LYS A CE  1 
ATOM   3037 N  NZ  . LYS A 1 426 ? -2.176  -38.488 -16.746 1.00 73.11  ? 689  LYS A NZ  1 
ATOM   3038 N  N   . ASP A 1 427 ? 4.168   -36.029 -16.677 0.50 44.10  ? 690  ASP A N   1 
ATOM   3039 C  CA  . ASP A 1 427 ? 5.097   -37.190 -16.523 0.50 44.36  ? 690  ASP A CA  1 
ATOM   3040 C  C   . ASP A 1 427 ? 6.238   -37.163 -17.553 0.50 45.26  ? 690  ASP A C   1 
ATOM   3041 O  O   . ASP A 1 427 ? 6.622   -38.263 -18.017 0.50 47.22  ? 690  ASP A O   1 
ATOM   3042 C  CB  . ASP A 1 427 ? 4.368   -38.525 -16.705 0.50 44.19  ? 690  ASP A CB  1 
ATOM   3043 C  CG  . ASP A 1 427 ? 3.223   -38.753 -15.738 0.50 45.82  ? 690  ASP A CG  1 
ATOM   3044 O  OD1 . ASP A 1 427 ? 3.228   -38.104 -14.670 0.50 47.25  ? 690  ASP A OD1 1 
ATOM   3045 O  OD2 . ASP A 1 427 ? 2.331   -39.575 -16.067 0.50 45.97  ? 690  ASP A OD2 1 
ATOM   3046 N  N   . ILE A 1 428 ? 6.711   -35.971 -17.930 1.00 43.22  ? 691  ILE A N   1 
ATOM   3047 C  CA  . ILE A 1 428 ? 7.861   -35.806 -18.870 1.00 43.51  ? 691  ILE A CA  1 
ATOM   3048 C  C   . ILE A 1 428 ? 8.445   -34.413 -18.625 1.00 42.79  ? 691  ILE A C   1 
ATOM   3049 O  O   . ILE A 1 428 ? 7.683   -33.511 -18.288 1.00 44.68  ? 691  ILE A O   1 
ATOM   3050 C  CB  . ILE A 1 428 ? 7.463   -36.005 -20.349 1.00 41.31  ? 691  ILE A CB  1 
ATOM   3051 C  CG1 . ILE A 1 428 ? 8.691   -36.164 -21.247 1.00 40.83  ? 691  ILE A CG1 1 
ATOM   3052 C  CG2 . ILE A 1 428 ? 6.551   -34.888 -20.829 1.00 39.60  ? 691  ILE A CG2 1 
ATOM   3053 C  CD1 . ILE A 1 428 ? 8.380   -36.686 -22.625 1.00 41.33  ? 691  ILE A CD1 1 
ATOM   3054 N  N   . GLN A 1 429 ? 9.759   -34.264 -18.762 1.00 44.76  ? 692  GLN A N   1 
ATOM   3055 C  CA  . GLN A 1 429 ? 10.416  -32.950 -18.542 1.00 45.40  ? 692  GLN A CA  1 
ATOM   3056 C  C   . GLN A 1 429 ? 9.955   -31.968 -19.620 1.00 42.10  ? 692  GLN A C   1 
ATOM   3057 O  O   . GLN A 1 429 ? 9.816   -32.392 -20.768 1.00 38.60  ? 692  GLN A O   1 
ATOM   3058 C  CB  . GLN A 1 429 ? 11.936  -33.102 -18.467 1.00 56.00  ? 692  GLN A CB  1 
ATOM   3059 C  CG  . GLN A 1 429 ? 12.373  -34.101 -17.405 1.00 69.15  ? 692  GLN A CG  1 
ATOM   3060 C  CD  . GLN A 1 429 ? 13.862  -34.097 -17.164 1.00 82.88  ? 692  GLN A CD  1 
ATOM   3061 O  OE1 . GLN A 1 429 ? 14.653  -34.468 -18.027 1.00 88.76  ? 692  GLN A OE1 1 
ATOM   3062 N  NE2 . GLN A 1 429 ? 14.255  -33.685 -15.969 1.00 86.65  ? 692  GLN A NE2 1 
ATOM   3063 N  N   . GLN A 1 430 ? 9.806   -30.696 -19.260 0.50 45.34  ? 693  GLN A N   1 
ATOM   3064 C  CA  . GLN A 1 430 ? 9.226   -29.676 -20.174 0.50 45.97  ? 693  GLN A CA  1 
ATOM   3065 C  C   . GLN A 1 430 ? 9.823   -29.708 -21.579 0.50 44.76  ? 693  GLN A C   1 
ATOM   3066 O  O   . GLN A 1 430 ? 9.058   -29.482 -22.526 0.50 43.83  ? 693  GLN A O   1 
ATOM   3067 C  CB  . GLN A 1 430 ? 9.434   -28.287 -19.571 0.50 49.12  ? 693  GLN A CB  1 
ATOM   3068 C  CG  . GLN A 1 430 ? 8.357   -27.289 -19.964 0.50 51.11  ? 693  GLN A CG  1 
ATOM   3069 C  CD  . GLN A 1 430 ? 8.619   -25.921 -19.388 0.50 49.38  ? 693  GLN A CD  1 
ATOM   3070 O  OE1 . GLN A 1 430 ? 9.709   -25.631 -18.902 0.50 49.09  ? 693  GLN A OE1 1 
ATOM   3071 N  NE2 . GLN A 1 430 ? 7.614   -25.063 -19.445 0.50 48.49  ? 693  GLN A NE2 1 
ATOM   3072 N  N   . TRP A 1 431 ? 11.125  -29.952 -21.716 1.00 43.53  ? 694  TRP A N   1 
ATOM   3073 C  CA  . TRP A 1 431 ? 11.748  -29.842 -23.060 1.00 39.49  ? 694  TRP A CA  1 
ATOM   3074 C  C   . TRP A 1 431 ? 12.197  -31.199 -23.612 1.00 36.38  ? 694  TRP A C   1 
ATOM   3075 O  O   . TRP A 1 431 ? 12.844  -31.203 -24.661 1.00 41.84  ? 694  TRP A O   1 
ATOM   3076 C  CB  . TRP A 1 431 ? 12.871  -28.806 -23.008 1.00 46.24  ? 694  TRP A CB  1 
ATOM   3077 C  CG  . TRP A 1 431 ? 12.370  -27.469 -22.557 1.00 51.72  ? 694  TRP A CG  1 
ATOM   3078 C  CD1 . TRP A 1 431 ? 12.618  -26.851 -21.367 1.00 51.40  ? 694  TRP A CD1 1 
ATOM   3079 C  CD2 . TRP A 1 431 ? 11.480  -26.602 -23.281 1.00 49.64  ? 694  TRP A CD2 1 
ATOM   3080 N  NE1 . TRP A 1 431 ? 11.963  -25.650 -21.310 1.00 54.34  ? 694  TRP A NE1 1 
ATOM   3081 C  CE2 . TRP A 1 431 ? 11.258  -25.470 -22.470 1.00 53.15  ? 694  TRP A CE2 1 
ATOM   3082 C  CE3 . TRP A 1 431 ? 10.864  -26.664 -24.534 1.00 46.05  ? 694  TRP A CE3 1 
ATOM   3083 C  CZ2 . TRP A 1 431 ? 10.441  -24.416 -22.874 1.00 49.59  ? 694  TRP A CZ2 1 
ATOM   3084 C  CZ3 . TRP A 1 431 ? 10.062  -25.620 -24.934 1.00 50.10  ? 694  TRP A CZ3 1 
ATOM   3085 C  CH2 . TRP A 1 431 ? 9.853   -24.514 -24.113 1.00 46.71  ? 694  TRP A CH2 1 
ATOM   3086 N  N   . GLU A 1 432 ? 11.848  -32.290 -22.937 1.00 35.86  ? 695  GLU A N   1 
ATOM   3087 C  CA  . GLU A 1 432 ? 12.144  -33.640 -23.468 1.00 38.35  ? 695  GLU A CA  1 
ATOM   3088 C  C   . GLU A 1 432 ? 11.145  -33.946 -24.590 1.00 37.27  ? 695  GLU A C   1 
ATOM   3089 O  O   . GLU A 1 432 ? 9.950   -33.722 -24.404 1.00 32.87  ? 695  GLU A O   1 
ATOM   3090 C  CB  . GLU A 1 432 ? 12.086  -34.670 -22.342 1.00 42.12  ? 695  GLU A CB  1 
ATOM   3091 C  CG  . GLU A 1 432 ? 12.452  -36.077 -22.775 1.00 54.76  ? 695  GLU A CG  1 
ATOM   3092 C  CD  . GLU A 1 432 ? 13.907  -36.284 -23.163 1.00 63.16  ? 695  GLU A CD  1 
ATOM   3093 O  OE1 . GLU A 1 432 ? 14.216  -37.346 -23.733 1.00 60.41  ? 695  GLU A OE1 1 
ATOM   3094 O  OE2 . GLU A 1 432 ? 14.726  -35.385 -22.894 1.00 63.12  ? 695  GLU A OE2 1 
ATOM   3095 N  N   . PRO A 1 433 ? 11.608  -34.434 -25.750 1.00 36.02  ? 696  PRO A N   1 
ATOM   3096 C  CA  . PRO A 1 433 ? 10.712  -34.770 -26.836 1.00 32.59  ? 696  PRO A CA  1 
ATOM   3097 C  C   . PRO A 1 433 ? 9.679   -35.844 -26.477 1.00 31.47  ? 696  PRO A C   1 
ATOM   3098 O  O   . PRO A 1 433 ? 10.000  -36.746 -25.762 1.00 28.10  ? 696  PRO A O   1 
ATOM   3099 C  CB  . PRO A 1 433 ? 11.645  -35.294 -27.930 1.00 38.52  ? 696  PRO A CB  1 
ATOM   3100 C  CG  . PRO A 1 433 ? 12.983  -34.678 -27.593 1.00 41.43  ? 696  PRO A CG  1 
ATOM   3101 C  CD  . PRO A 1 433 ? 13.012  -34.662 -26.081 1.00 36.88  ? 696  PRO A CD  1 
ATOM   3102 N  N   . SER A 1 434 ? 8.459   -35.672 -26.979 0.50 30.56  ? 697  SER A N   1 
ATOM   3103 C  CA  . SER A 1 434 ? 7.355   -36.638 -26.762 0.50 29.64  ? 697  SER A CA  1 
ATOM   3104 C  C   . SER A 1 434 ? 7.788   -38.022 -27.245 0.50 30.60  ? 697  SER A C   1 
ATOM   3105 O  O   . SER A 1 434 ? 8.456   -38.101 -28.277 0.50 31.91  ? 697  SER A O   1 
ATOM   3106 C  CB  . SER A 1 434 ? 6.103   -36.201 -27.476 0.50 27.52  ? 697  SER A CB  1 
ATOM   3107 O  OG  . SER A 1 434 ? 5.564   -35.044 -26.879 0.50 28.10  ? 697  SER A OG  1 
ATOM   3108 N  N   . ARG A 1 435 ? 7.383   -39.068 -26.533 0.50 33.21  ? 698  ARG A N   1 
ATOM   3109 C  CA  . ARG A 1 435 ? 7.509   -40.473 -26.990 0.50 37.53  ? 698  ARG A CA  1 
ATOM   3110 C  C   . ARG A 1 435 ? 6.183   -40.876 -27.649 0.50 35.49  ? 698  ARG A C   1 
ATOM   3111 O  O   . ARG A 1 435 ? 5.154   -40.874 -26.950 0.50 35.99  ? 698  ARG A O   1 
ATOM   3112 C  CB  . ARG A 1 435 ? 7.880   -41.358 -25.795 0.50 43.56  ? 698  ARG A CB  1 
ATOM   3113 C  CG  . ARG A 1 435 ? 9.154   -40.908 -25.090 0.50 49.73  ? 698  ARG A CG  1 
ATOM   3114 C  CD  . ARG A 1 435 ? 9.480   -41.707 -23.840 0.50 55.21  ? 698  ARG A CD  1 
ATOM   3115 N  NE  . ARG A 1 435 ? 8.782   -41.232 -22.648 0.50 61.05  ? 698  ARG A NE  1 
ATOM   3116 C  CZ  . ARG A 1 435 ? 9.265   -40.333 -21.790 0.50 62.94  ? 698  ARG A CZ  1 
ATOM   3117 N  NH1 . ARG A 1 435 ? 10.454  -39.787 -21.992 0.50 62.49  ? 698  ARG A NH1 1 
ATOM   3118 N  NH2 . ARG A 1 435 ? 8.552   -39.978 -20.736 0.50 63.35  ? 698  ARG A NH2 1 
ATOM   3119 N  N   . GLY A 1 436 ? 6.211   -41.179 -28.947 1.00 33.11  ? 699  GLY A N   1 
ATOM   3120 C  CA  . GLY A 1 436 ? 5.018   -41.582 -29.704 1.00 37.48  ? 699  GLY A CA  1 
ATOM   3121 C  C   . GLY A 1 436 ? 4.849   -43.097 -29.762 1.00 35.77  ? 699  GLY A C   1 
ATOM   3122 O  O   . GLY A 1 436 ? 5.719   -43.829 -29.328 1.00 31.64  ? 699  GLY A O   1 
ATOM   3123 N  N   . TRP A 1 437 ? 3.737   -43.548 -30.317 1.00 30.47  ? 700  TRP A N   1 
ATOM   3124 C  CA  . TRP A 1 437 ? 3.372   -44.970 -30.377 1.00 27.42  ? 700  TRP A CA  1 
ATOM   3125 C  C   . TRP A 1 437 ? 3.479   -45.375 -31.824 1.00 29.56  ? 700  TRP A C   1 
ATOM   3126 O  O   . TRP A 1 437 ? 3.014   -44.602 -32.672 1.00 27.96  ? 700  TRP A O   1 
ATOM   3127 C  CB  . TRP A 1 437 ? 1.941   -45.129 -29.863 1.00 27.09  ? 700  TRP A CB  1 
ATOM   3128 C  CG  . TRP A 1 437 ? 1.813   -44.692 -28.446 1.00 24.63  ? 700  TRP A CG  1 
ATOM   3129 C  CD1 . TRP A 1 437 ? 1.473   -43.455 -28.000 1.00 26.92  ? 700  TRP A CD1 1 
ATOM   3130 C  CD2 . TRP A 1 437 ? 1.946   -45.522 -27.288 1.00 25.83  ? 700  TRP A CD2 1 
ATOM   3131 N  NE1 . TRP A 1 437 ? 1.474   -43.437 -26.640 1.00 27.78  ? 700  TRP A NE1 1 
ATOM   3132 C  CE2 . TRP A 1 437 ? 1.710   -44.703 -26.177 1.00 25.54  ? 700  TRP A CE2 1 
ATOM   3133 C  CE3 . TRP A 1 437 ? 2.263   -46.861 -27.100 1.00 26.41  ? 700  TRP A CE3 1 
ATOM   3134 C  CZ2 . TRP A 1 437 ? 1.769   -45.173 -24.872 1.00 27.02  ? 700  TRP A CZ2 1 
ATOM   3135 C  CZ3 . TRP A 1 437 ? 2.331   -47.328 -25.817 1.00 29.39  ? 700  TRP A CZ3 1 
ATOM   3136 C  CH2 . TRP A 1 437 ? 2.059   -46.499 -24.723 1.00 29.51  ? 700  TRP A CH2 1 
ATOM   3137 N  N   . ASN A 1 438 ? 4.056   -46.530 -32.089 1.00 27.65  ? 701  ASN A N   1 
ATOM   3138 C  CA  . ASN A 1 438 ? 4.202   -47.035 -33.474 1.00 30.31  ? 701  ASN A CA  1 
ATOM   3139 C  C   . ASN A 1 438 ? 3.031   -47.900 -33.898 1.00 32.10  ? 701  ASN A C   1 
ATOM   3140 O  O   . ASN A 1 438 ? 3.023   -48.279 -35.058 1.00 34.28  ? 701  ASN A O   1 
ATOM   3141 C  CB  . ASN A 1 438 ? 5.476   -47.893 -33.582 1.00 36.85  ? 701  ASN A CB  1 
ATOM   3142 C  CG  . ASN A 1 438 ? 6.695   -47.061 -33.220 1.00 47.56  ? 701  ASN A CG  1 
ATOM   3143 O  OD1 . ASN A 1 438 ? 7.469   -47.420 -32.315 1.00 55.02  ? 701  ASN A OD1 1 
ATOM   3144 N  ND2 . ASN A 1 438 ? 6.801   -45.902 -33.864 1.00 40.04  ? 701  ASN A ND2 1 
ATOM   3145 N  N   . ASP A 1 439 ? 2.098   -48.237 -33.014 1.00 32.27  ? 702  ASP A N   1 
ATOM   3146 C  CA  . ASP A 1 439 ? 1.010   -49.200 -33.346 1.00 34.01  ? 702  ASP A CA  1 
ATOM   3147 C  C   . ASP A 1 439 ? -0.273  -48.665 -32.701 1.00 29.23  ? 702  ASP A C   1 
ATOM   3148 O  O   . ASP A 1 439 ? -0.269  -48.418 -31.473 1.00 29.50  ? 702  ASP A O   1 
ATOM   3149 C  CB  . ASP A 1 439 ? 1.475   -50.584 -32.877 1.00 39.27  ? 702  ASP A CB  1 
ATOM   3150 C  CG  . ASP A 1 439 ? 0.451   -51.704 -32.824 1.00 43.91  ? 702  ASP A CG  1 
ATOM   3151 O  OD1 . ASP A 1 439 ? -0.707  -51.530 -33.357 1.00 42.00  ? 702  ASP A OD1 1 
ATOM   3152 O  OD2 . ASP A 1 439 ? 0.831   -52.765 -32.202 1.00 52.40  ? 702  ASP A OD2 1 
ATOM   3153 N  N   . TRP A 1 440 ? -1.289  -48.427 -33.516 1.00 27.98  ? 703  TRP A N   1 
ATOM   3154 C  CA  . TRP A 1 440 ? -2.564  -47.834 -33.071 1.00 28.24  ? 703  TRP A CA  1 
ATOM   3155 C  C   . TRP A 1 440 ? -3.184  -48.698 -31.961 1.00 26.96  ? 703  TRP A C   1 
ATOM   3156 O  O   . TRP A 1 440 ? -3.946  -48.151 -31.104 1.00 26.72  ? 703  TRP A O   1 
ATOM   3157 C  CB  . TRP A 1 440 ? -3.472  -47.613 -34.264 1.00 29.42  ? 703  TRP A CB  1 
ATOM   3158 C  CG  . TRP A 1 440 ? -4.003  -48.856 -34.914 1.00 29.54  ? 703  TRP A CG  1 
ATOM   3159 C  CD1 . TRP A 1 440 ? -3.514  -49.476 -36.031 1.00 33.45  ? 703  TRP A CD1 1 
ATOM   3160 C  CD2 . TRP A 1 440 ? -5.150  -49.619 -34.521 1.00 29.62  ? 703  TRP A CD2 1 
ATOM   3161 N  NE1 . TRP A 1 440 ? -4.292  -50.556 -36.369 1.00 30.20  ? 703  TRP A NE1 1 
ATOM   3162 C  CE2 . TRP A 1 440 ? -5.279  -50.697 -35.441 1.00 30.37  ? 703  TRP A CE2 1 
ATOM   3163 C  CE3 . TRP A 1 440 ? -6.099  -49.494 -33.510 1.00 29.06  ? 703  TRP A CE3 1 
ATOM   3164 C  CZ2 . TRP A 1 440 ? -6.321  -51.628 -35.378 1.00 29.34  ? 703  TRP A CZ2 1 
ATOM   3165 C  CZ3 . TRP A 1 440 ? -7.124  -50.417 -33.448 1.00 30.25  ? 703  TRP A CZ3 1 
ATOM   3166 C  CH2 . TRP A 1 440 ? -7.217  -51.482 -34.349 1.00 31.91  ? 703  TRP A CH2 1 
ATOM   3167 N  N   . THR A 1 441 ? -2.854  -49.979 -31.910 1.00 25.88  ? 704  THR A N   1 
ATOM   3168 C  CA  . THR A 1 441 ? -3.412  -50.906 -30.881 1.00 26.46  ? 704  THR A CA  1 
ATOM   3169 C  C   . THR A 1 441 ? -2.794  -50.718 -29.503 1.00 25.42  ? 704  THR A C   1 
ATOM   3170 O  O   . THR A 1 441 ? -3.295  -51.319 -28.530 1.00 27.99  ? 704  THR A O   1 
ATOM   3171 C  CB  . THR A 1 441 ? -3.348  -52.382 -31.301 1.00 25.67  ? 704  THR A CB  1 
ATOM   3172 O  OG1 . THR A 1 441 ? -1.989  -52.805 -31.350 1.00 24.52  ? 704  THR A OG1 1 
ATOM   3173 C  CG2 . THR A 1 441 ? -4.016  -52.617 -32.635 1.00 23.00  ? 704  THR A CG2 1 
ATOM   3174 N  N   . GLN A 1 442 ? -1.734  -49.909 -29.395 0.50 25.92  ? 705  GLN A N   1 
ATOM   3175 C  CA  . GLN A 1 442 ? -1.054  -49.616 -28.108 0.50 26.97  ? 705  GLN A CA  1 
ATOM   3176 C  C   . GLN A 1 442 ? -1.357  -48.194 -27.623 0.50 24.63  ? 705  GLN A C   1 
ATOM   3177 O  O   . GLN A 1 442 ? -0.987  -47.897 -26.480 0.50 25.28  ? 705  GLN A O   1 
ATOM   3178 C  CB  . GLN A 1 442 ? 0.452   -49.817 -28.272 0.50 29.94  ? 705  GLN A CB  1 
ATOM   3179 C  CG  . GLN A 1 442 ? 0.777   -51.096 -29.025 0.50 32.55  ? 705  GLN A CG  1 
ATOM   3180 C  CD  . GLN A 1 442 ? 0.283   -52.298 -28.265 0.50 35.08  ? 705  GLN A CD  1 
ATOM   3181 O  OE1 . GLN A 1 442 ? 0.621   -52.484 -27.101 0.50 34.92  ? 705  GLN A OE1 1 
ATOM   3182 N  NE2 . GLN A 1 442 ? -0.519  -53.129 -28.921 0.50 38.55  ? 705  GLN A NE2 1 
ATOM   3183 N  N   . VAL A 1 443 ? -1.961  -47.348 -28.460 1.00 24.00  ? 706  VAL A N   1 
ATOM   3184 C  CA  . VAL A 1 443 ? -2.272  -45.923 -28.099 1.00 26.09  ? 706  VAL A CA  1 
ATOM   3185 C  C   . VAL A 1 443 ? -3.338  -45.871 -27.011 1.00 23.18  ? 706  VAL A C   1 
ATOM   3186 O  O   . VAL A 1 443 ? -4.382  -46.482 -27.165 1.00 25.51  ? 706  VAL A O   1 
ATOM   3187 C  CB  . VAL A 1 443 ? -2.698  -45.127 -29.349 1.00 29.14  ? 706  VAL A CB  1 
ATOM   3188 C  CG1 . VAL A 1 443 ? -3.176  -43.730 -29.035 1.00 33.08  ? 706  VAL A CG1 1 
ATOM   3189 C  CG2 . VAL A 1 443 ? -1.554  -45.053 -30.320 1.00 32.89  ? 706  VAL A CG2 1 
ATOM   3190 N  N   . PRO A 1 444 ? -3.120  -45.147 -25.883 1.00 23.12  ? 707  PRO A N   1 
ATOM   3191 C  CA  . PRO A 1 444 ? -4.185  -44.910 -24.917 1.00 22.07  ? 707  PRO A CA  1 
ATOM   3192 C  C   . PRO A 1 444 ? -5.145  -43.803 -25.395 1.00 21.85  ? 707  PRO A C   1 
ATOM   3193 O  O   . PRO A 1 444 ? -4.712  -42.789 -25.928 1.00 20.64  ? 707  PRO A O   1 
ATOM   3194 C  CB  . PRO A 1 444 ? -3.428  -44.476 -23.665 1.00 24.46  ? 707  PRO A CB  1 
ATOM   3195 C  CG  . PRO A 1 444 ? -2.156  -43.770 -24.213 1.00 24.35  ? 707  PRO A CG  1 
ATOM   3196 C  CD  . PRO A 1 444 ? -1.893  -44.403 -25.555 1.00 23.90  ? 707  PRO A CD  1 
ATOM   3197 N  N   . PHE A 1 445 ? -6.448  -43.988 -25.209 1.00 21.16  ? 708  PHE A N   1 
ATOM   3198 C  CA  . PHE A 1 445 ? -7.434  -42.917 -25.493 1.00 22.61  ? 708  PHE A CA  1 
ATOM   3199 C  C   . PHE A 1 445 ? -8.691  -43.186 -24.685 1.00 22.95  ? 708  PHE A C   1 
ATOM   3200 O  O   . PHE A 1 445 ? -9.158  -44.349 -24.708 1.00 19.68  ? 708  PHE A O   1 
ATOM   3201 C  CB  . PHE A 1 445 ? -7.727  -42.881 -26.999 1.00 21.77  ? 708  PHE A CB  1 
ATOM   3202 C  CG  . PHE A 1 445 ? -8.616  -41.758 -27.512 1.00 24.08  ? 708  PHE A CG  1 
ATOM   3203 C  CD1 . PHE A 1 445 ? -8.340  -40.437 -27.207 1.00 22.77  ? 708  PHE A CD1 1 
ATOM   3204 C  CD2 . PHE A 1 445 ? -9.734  -42.043 -28.294 1.00 24.48  ? 708  PHE A CD2 1 
ATOM   3205 C  CE1 . PHE A 1 445 ? -9.133  -39.406 -27.709 1.00 24.69  ? 708  PHE A CE1 1 
ATOM   3206 C  CE2 . PHE A 1 445 ? -10.502 -41.013 -28.837 1.00 26.41  ? 708  PHE A CE2 1 
ATOM   3207 C  CZ  . PHE A 1 445 ? -10.226 -39.703 -28.501 1.00 25.97  ? 708  PHE A CZ  1 
ATOM   3208 N  N   . CYS A 1 446 ? -9.197  -42.152 -24.007 1.00 22.88  ? 709  CYS A N   1 
ATOM   3209 C  CA  . CYS A 1 446 ? -10.461 -42.220 -23.191 1.00 24.39  ? 709  CYS A CA  1 
ATOM   3210 C  C   . CYS A 1 446 ? -10.393 -43.423 -22.240 1.00 22.21  ? 709  CYS A C   1 
ATOM   3211 O  O   . CYS A 1 446 ? -11.372 -44.209 -22.161 1.00 23.38  ? 709  CYS A O   1 
ATOM   3212 C  CB  . CYS A 1 446 ? -11.668 -42.301 -24.105 1.00 25.35  ? 709  CYS A CB  1 
ATOM   3213 S  SG  . CYS A 1 446 ? -11.873 -40.818 -25.135 1.00 26.81  ? 709  CYS A SG  1 
ATOM   3214 N  N   . SER A 1 447 ? -9.224  -43.629 -21.637 1.00 22.87  ? 710  SER A N   1 
ATOM   3215 C  CA  . SER A 1 447 ? -8.961  -44.622 -20.573 1.00 27.58  ? 710  SER A CA  1 
ATOM   3216 C  C   . SER A 1 447 ? -8.922  -46.047 -21.149 1.00 24.17  ? 710  SER A C   1 
ATOM   3217 O  O   . SER A 1 447 ? -8.931  -46.996 -20.352 1.00 24.58  ? 710  SER A O   1 
ATOM   3218 C  CB  . SER A 1 447 ? -10.036 -44.545 -19.478 1.00 30.18  ? 710  SER A CB  1 
ATOM   3219 O  OG  . SER A 1 447 ? -10.010 -43.285 -18.836 1.00 35.12  ? 710  SER A OG  1 
ATOM   3220 N  N   . HIS A 1 448 ? -8.842  -46.206 -22.455 1.00 22.21  ? 711  HIS A N   1 
ATOM   3221 C  CA  . HIS A 1 448 ? -8.839  -47.533 -23.119 1.00 20.69  ? 711  HIS A CA  1 
ATOM   3222 C  C   . HIS A 1 448 ? -7.621  -47.710 -24.038 1.00 20.30  ? 711  HIS A C   1 
ATOM   3223 O  O   . HIS A 1 448 ? -6.941  -46.724 -24.357 1.00 20.44  ? 711  HIS A O   1 
ATOM   3224 C  CB  . HIS A 1 448 ? -10.133 -47.740 -23.917 1.00 20.46  ? 711  HIS A CB  1 
ATOM   3225 C  CG  . HIS A 1 448 ? -11.332 -47.932 -23.033 1.00 20.94  ? 711  HIS A CG  1 
ATOM   3226 N  ND1 . HIS A 1 448 ? -11.929 -46.892 -22.346 1.00 21.24  ? 711  HIS A ND1 1 
ATOM   3227 C  CD2 . HIS A 1 448 ? -12.042 -49.057 -22.756 1.00 20.58  ? 711  HIS A CD2 1 
ATOM   3228 C  CE1 . HIS A 1 448 ? -12.958 -47.382 -21.655 1.00 24.45  ? 711  HIS A CE1 1 
ATOM   3229 N  NE2 . HIS A 1 448 ? -13.061 -48.724 -21.876 1.00 21.34  ? 711  HIS A NE2 1 
ATOM   3230 N  N   . HIS A 1 449 ? -7.415  -48.953 -24.459 1.00 18.79  ? 712  HIS A N   1 
ATOM   3231 C  CA  . HIS A 1 449 ? -6.728  -49.305 -25.710 1.00 20.45  ? 712  HIS A CA  1 
ATOM   3232 C  C   . HIS A 1 449 ? -7.644  -50.203 -26.510 1.00 21.03  ? 712  HIS A C   1 
ATOM   3233 O  O   . HIS A 1 449 ? -8.760  -50.497 -26.036 1.00 22.29  ? 712  HIS A O   1 
ATOM   3234 C  CB  . HIS A 1 449 ? -5.377  -49.992 -25.431 1.00 19.49  ? 712  HIS A CB  1 
ATOM   3235 C  CG  . HIS A 1 449 ? -5.556  -51.196 -24.585 1.00 18.55  ? 712  HIS A CG  1 
ATOM   3236 N  ND1 . HIS A 1 449 ? -5.713  -51.100 -23.225 1.00 20.10  ? 712  HIS A ND1 1 
ATOM   3237 C  CD2 . HIS A 1 449 ? -5.648  -52.496 -24.886 1.00 18.52  ? 712  HIS A CD2 1 
ATOM   3238 C  CE1 . HIS A 1 449 ? -5.857  -52.321 -22.724 1.00 19.28  ? 712  HIS A CE1 1 
ATOM   3239 N  NE2 . HIS A 1 449 ? -5.817  -53.178 -23.701 1.00 19.25  ? 712  HIS A NE2 1 
ATOM   3240 N  N   . PHE A 1 450 ? -7.249  -50.489 -27.741 1.00 20.26  ? 713  PHE A N   1 
ATOM   3241 C  CA  . PHE A 1 450 ? -8.140  -51.147 -28.720 1.00 22.19  ? 713  PHE A CA  1 
ATOM   3242 C  C   . PHE A 1 450 ? -7.414  -52.327 -29.368 1.00 22.29  ? 713  PHE A C   1 
ATOM   3243 O  O   . PHE A 1 450 ? -6.222  -52.229 -29.743 1.00 23.39  ? 713  PHE A O   1 
ATOM   3244 C  CB  . PHE A 1 450 ? -8.722  -50.125 -29.706 1.00 23.99  ? 713  PHE A CB  1 
ATOM   3245 C  CG  . PHE A 1 450 ? -9.446  -48.995 -29.008 1.00 22.46  ? 713  PHE A CG  1 
ATOM   3246 C  CD1 . PHE A 1 450 ? -8.730  -47.954 -28.457 1.00 25.47  ? 713  PHE A CD1 1 
ATOM   3247 C  CD2 . PHE A 1 450 ? -10.805 -49.043 -28.776 1.00 24.03  ? 713  PHE A CD2 1 
ATOM   3248 C  CE1 . PHE A 1 450 ? -9.365  -46.957 -27.731 1.00 24.95  ? 713  PHE A CE1 1 
ATOM   3249 C  CE2 . PHE A 1 450 ? -11.447 -48.019 -28.078 1.00 25.88  ? 713  PHE A CE2 1 
ATOM   3250 C  CZ  . PHE A 1 450 ? -10.722 -46.973 -27.566 1.00 24.53  ? 713  PHE A CZ  1 
ATOM   3251 N  N   . HIS A 1 451 ? -8.146  -53.448 -29.479 1.00 22.09  ? 714  HIS A N   1 
ATOM   3252 C  CA  . HIS A 1 451 ? -7.647  -54.703 -30.096 1.00 22.20  ? 714  HIS A CA  1 
ATOM   3253 C  C   . HIS A 1 451 ? -8.341  -54.902 -31.452 1.00 23.85  ? 714  HIS A C   1 
ATOM   3254 O  O   . HIS A 1 451 ? -9.561  -54.591 -31.592 1.00 23.94  ? 714  HIS A O   1 
ATOM   3255 C  CB  . HIS A 1 451 ? -7.886  -55.883 -29.139 1.00 21.16  ? 714  HIS A CB  1 
ATOM   3256 C  CG  . HIS A 1 451 ? -7.155  -55.870 -27.821 1.00 20.88  ? 714  HIS A CG  1 
ATOM   3257 N  ND1 . HIS A 1 451 ? -6.044  -56.619 -27.619 1.00 21.04  ? 714  HIS A ND1 1 
ATOM   3258 C  CD2 . HIS A 1 451 ? -7.429  -55.272 -26.631 1.00 20.80  ? 714  HIS A CD2 1 
ATOM   3259 C  CE1 . HIS A 1 451 ? -5.637  -56.499 -26.334 1.00 20.58  ? 714  HIS A CE1 1 
ATOM   3260 N  NE2 . HIS A 1 451 ? -6.494  -55.646 -25.660 1.00 14.87  ? 714  HIS A NE2 1 
ATOM   3261 N  N   . GLU A 1 452 ? -7.623  -55.487 -32.403 1.00 24.77  ? 715  GLU A N   1 
ATOM   3262 C  CA  . GLU A 1 452 ? -8.146  -55.984 -33.690 1.00 24.68  ? 715  GLU A CA  1 
ATOM   3263 C  C   . GLU A 1 452 ? -8.480  -57.476 -33.530 1.00 29.28  ? 715  GLU A C   1 
ATOM   3264 O  O   . GLU A 1 452 ? -7.621  -58.242 -33.136 1.00 30.25  ? 715  GLU A O   1 
ATOM   3265 C  CB  . GLU A 1 452 ? -7.139  -55.726 -34.812 1.00 30.52  ? 715  GLU A CB  1 
ATOM   3266 C  CG  . GLU A 1 452 ? -7.863  -55.327 -36.087 1.00 36.71  ? 715  GLU A CG  1 
ATOM   3267 C  CD  . GLU A 1 452 ? -7.010  -55.025 -37.321 1.00 44.24  ? 715  GLU A CD  1 
ATOM   3268 O  OE1 . GLU A 1 452 ? -7.459  -54.210 -38.180 1.00 39.52  ? 715  GLU A OE1 1 
ATOM   3269 O  OE2 . GLU A 1 452 ? -5.946  -55.664 -37.454 1.00 51.09  ? 715  GLU A OE2 1 
ATOM   3270 N  N   . LEU A 1 453 ? -9.737  -57.854 -33.630 1.00 25.30  ? 716  LEU A N   1 
ATOM   3271 C  CA  . LEU A 1 453 ? -10.166 -59.229 -33.275 1.00 30.52  ? 716  LEU A CA  1 
ATOM   3272 C  C   . LEU A 1 453 ? -10.880 -59.829 -34.490 1.00 33.01  ? 716  LEU A C   1 
ATOM   3273 O  O   . LEU A 1 453 ? -11.813 -59.205 -34.988 1.00 31.14  ? 716  LEU A O   1 
ATOM   3274 C  CB  . LEU A 1 453 ? -11.040 -59.053 -32.039 1.00 35.16  ? 716  LEU A CB  1 
ATOM   3275 C  CG  . LEU A 1 453 ? -11.815 -60.257 -31.555 1.00 39.71  ? 716  LEU A CG  1 
ATOM   3276 C  CD1 . LEU A 1 453 ? -10.864 -61.388 -31.251 1.00 43.92  ? 716  LEU A CD1 1 
ATOM   3277 C  CD2 . LEU A 1 453 ? -12.630 -59.862 -30.325 1.00 40.44  ? 716  LEU A CD2 1 
ATOM   3278 N  N   . ILE A 1 454 ? -10.379 -60.944 -35.016 1.00 31.73  ? 717  ILE A N   1 
ATOM   3279 C  CA  . ILE A 1 454 ? -10.944 -61.526 -36.264 1.00 33.38  ? 717  ILE A CA  1 
ATOM   3280 C  C   . ILE A 1 454 ? -11.927 -62.635 -35.884 1.00 29.29  ? 717  ILE A C   1 
ATOM   3281 O  O   . ILE A 1 454 ? -11.621 -63.492 -35.040 1.00 31.79  ? 717  ILE A O   1 
ATOM   3282 C  CB  . ILE A 1 454 ? -9.829  -61.964 -37.233 1.00 44.41  ? 717  ILE A CB  1 
ATOM   3283 C  CG1 . ILE A 1 454 ? -8.915  -60.786 -37.598 1.00 42.87  ? 717  ILE A CG1 1 
ATOM   3284 C  CG2 . ILE A 1 454 ? -10.398 -62.595 -38.504 1.00 45.60  ? 717  ILE A CG2 1 
ATOM   3285 C  CD1 . ILE A 1 454 ? -7.565  -61.256 -38.035 1.00 47.82  ? 717  ILE A CD1 1 
ATOM   3286 N  N   . MET A 1 455 ? -13.130 -62.505 -36.392 1.00 29.97  ? 718  MET A N   1 
ATOM   3287 C  CA  . MET A 1 455 ? -14.199 -63.506 -36.162 1.00 34.09  ? 718  MET A CA  1 
ATOM   3288 C  C   . MET A 1 455 ? -13.889 -64.770 -36.965 1.00 36.91  ? 718  MET A C   1 
ATOM   3289 O  O   . MET A 1 455 ? -13.241 -64.694 -38.034 1.00 33.10  ? 718  MET A O   1 
ATOM   3290 C  CB  . MET A 1 455 ? -15.539 -62.941 -36.621 1.00 32.32  ? 718  MET A CB  1 
ATOM   3291 C  CG  . MET A 1 455 ? -15.965 -61.782 -35.765 1.00 33.41  ? 718  MET A CG  1 
ATOM   3292 S  SD  . MET A 1 455 ? -17.463 -60.995 -36.327 1.00 36.34  ? 718  MET A SD  1 
ATOM   3293 C  CE  . MET A 1 455 ? -18.635 -62.268 -35.885 1.00 36.66  ? 718  MET A CE  1 
ATOM   3294 N  N   A LYS A 1 456 ? -14.353 -65.913 -36.465 0.25 37.53  ? 719  LYS A N   1 
ATOM   3295 N  N   B LYS A 1 456 ? -14.363 -65.911 -36.468 0.25 37.92  ? 719  LYS A N   1 
ATOM   3296 C  CA  A LYS A 1 456 ? -14.189 -67.233 -37.125 0.25 41.07  ? 719  LYS A CA  1 
ATOM   3297 C  CA  B LYS A 1 456 ? -14.186 -67.231 -37.123 0.25 41.75  ? 719  LYS A CA  1 
ATOM   3298 C  C   A LYS A 1 456 ? -14.571 -67.106 -38.605 0.25 39.35  ? 719  LYS A C   1 
ATOM   3299 C  C   B LYS A 1 456 ? -14.569 -67.104 -38.604 0.25 39.72  ? 719  LYS A C   1 
ATOM   3300 O  O   A LYS A 1 456 ? -13.941 -67.792 -39.421 0.25 41.34  ? 719  LYS A O   1 
ATOM   3301 O  O   B LYS A 1 456 ? -13.938 -67.791 -39.420 0.25 41.69  ? 719  LYS A O   1 
ATOM   3302 C  CB  A LYS A 1 456 ? -14.994 -68.300 -36.377 0.25 42.11  ? 719  LYS A CB  1 
ATOM   3303 C  CB  B LYS A 1 456 ? -14.989 -68.311 -36.389 0.25 43.35  ? 719  LYS A CB  1 
ATOM   3304 C  CG  A LYS A 1 456 ? -14.202 -69.063 -35.323 0.25 44.27  ? 719  LYS A CG  1 
ATOM   3305 C  CG  B LYS A 1 456 ? -14.648 -69.735 -36.805 0.25 46.42  ? 719  LYS A CG  1 
ATOM   3306 C  CD  A LYS A 1 456 ? -15.061 -69.850 -34.356 0.25 46.50  ? 719  LYS A CD  1 
ATOM   3307 C  CD  B LYS A 1 456 ? -15.140 -70.809 -35.858 0.25 47.86  ? 719  LYS A CD  1 
ATOM   3308 C  CE  A LYS A 1 456 ? -15.703 -68.986 -33.291 0.25 46.93  ? 719  LYS A CE  1 
ATOM   3309 C  CE  B LYS A 1 456 ? -15.236 -72.168 -36.522 0.25 49.23  ? 719  LYS A CE  1 
ATOM   3310 N  NZ  A LYS A 1 456 ? -16.669 -69.759 -32.475 0.25 47.51  ? 719  LYS A NZ  1 
ATOM   3311 N  NZ  B LYS A 1 456 ? -15.200 -73.272 -35.535 0.25 49.13  ? 719  LYS A NZ  1 
ATOM   3312 N  N   . ASP A 1 457 ? -15.524 -66.228 -38.938 1.00 39.53  ? 720  ASP A N   1 
ATOM   3313 C  CA  . ASP A 1 457 ? -15.976 -65.994 -40.346 1.00 39.01  ? 720  ASP A CA  1 
ATOM   3314 C  C   . ASP A 1 457 ? -15.152 -64.941 -41.123 1.00 48.47  ? 720  ASP A C   1 
ATOM   3315 O  O   . ASP A 1 457 ? -15.597 -64.543 -42.212 1.00 44.38  ? 720  ASP A O   1 
ATOM   3316 C  CB  . ASP A 1 457 ? -17.467 -65.613 -40.378 1.00 40.73  ? 720  ASP A CB  1 
ATOM   3317 C  CG  . ASP A 1 457 ? -17.847 -64.256 -39.784 1.00 44.13  ? 720  ASP A CG  1 
ATOM   3318 O  OD1 . ASP A 1 457 ? -16.972 -63.333 -39.798 1.00 38.26  ? 720  ASP A OD1 1 
ATOM   3319 O  OD2 . ASP A 1 457 ? -19.041 -64.106 -39.353 1.00 40.19  ? 720  ASP A OD2 1 
ATOM   3320 N  N   . GLY A 1 458 ? -14.033 -64.436 -40.591 1.00 49.68  ? 721  GLY A N   1 
ATOM   3321 C  CA  . GLY A 1 458 ? -13.157 -63.498 -41.319 1.00 43.67  ? 721  GLY A CA  1 
ATOM   3322 C  C   . GLY A 1 458 ? -13.482 -62.034 -41.070 1.00 43.18  ? 721  GLY A C   1 
ATOM   3323 O  O   . GLY A 1 458 ? -12.633 -61.206 -41.396 1.00 48.27  ? 721  GLY A O   1 
ATOM   3324 N  N   . ARG A 1 459 ? -14.656 -61.671 -40.537 1.00 36.81  ? 722  ARG A N   1 
ATOM   3325 C  CA  . ARG A 1 459 ? -14.966 -60.234 -40.367 1.00 33.35  ? 722  ARG A CA  1 
ATOM   3326 C  C   . ARG A 1 459 ? -14.120 -59.656 -39.201 1.00 32.99  ? 722  ARG A C   1 
ATOM   3327 O  O   . ARG A 1 459 ? -13.755 -60.396 -38.267 1.00 33.63  ? 722  ARG A O   1 
ATOM   3328 C  CB  . ARG A 1 459 ? -16.472 -60.032 -40.213 1.00 37.97  ? 722  ARG A CB  1 
ATOM   3329 C  CG  . ARG A 1 459 ? -17.288 -60.454 -41.429 1.00 38.57  ? 722  ARG A CG  1 
ATOM   3330 C  CD  . ARG A 1 459 ? -18.764 -60.172 -41.264 1.00 35.76  ? 722  ARG A CD  1 
ATOM   3331 N  NE  . ARG A 1 459 ? -19.362 -61.055 -40.296 1.00 34.15  ? 722  ARG A NE  1 
ATOM   3332 C  CZ  . ARG A 1 459 ? -20.645 -61.066 -40.022 1.00 32.97  ? 722  ARG A CZ  1 
ATOM   3333 N  NH1 . ARG A 1 459 ? -21.448 -60.197 -40.607 1.00 34.89  ? 722  ARG A NH1 1 
ATOM   3334 N  NH2 . ARG A 1 459 ? -21.123 -61.928 -39.147 1.00 36.25  ? 722  ARG A NH2 1 
ATOM   3335 N  N   . VAL A 1 460 ? -13.871 -58.359 -39.230 1.00 34.14  ? 723  VAL A N   1 
ATOM   3336 C  CA  . VAL A 1 460 ? -12.951 -57.671 -38.280 1.00 33.67  ? 723  VAL A CA  1 
ATOM   3337 C  C   . VAL A 1 460 ? -13.712 -56.822 -37.283 1.00 30.62  ? 723  VAL A C   1 
ATOM   3338 O  O   . VAL A 1 460 ? -14.446 -55.880 -37.667 1.00 39.45  ? 723  VAL A O   1 
ATOM   3339 C  CB  . VAL A 1 460 ? -11.872 -56.858 -39.000 1.00 38.64  ? 723  VAL A CB  1 
ATOM   3340 C  CG1 . VAL A 1 460 ? -10.820 -56.369 -38.004 1.00 41.50  ? 723  VAL A CG1 1 
ATOM   3341 C  CG2 . VAL A 1 460 ? -11.212 -57.707 -40.057 1.00 39.98  ? 723  VAL A CG2 1 
ATOM   3342 N  N   . LEU A 1 461 ? -13.487 -57.121 -36.007 1.00 28.74  ? 724  LEU A N   1 
ATOM   3343 C  CA  . LEU A 1 461 ? -13.971 -56.286 -34.891 1.00 25.30  ? 724  LEU A CA  1 
ATOM   3344 C  C   . LEU A 1 461 ? -12.791 -55.470 -34.339 1.00 28.20  ? 724  LEU A C   1 
ATOM   3345 O  O   . LEU A 1 461 ? -11.684 -56.032 -34.143 1.00 28.49  ? 724  LEU A O   1 
ATOM   3346 C  CB  . LEU A 1 461 ? -14.553 -57.199 -33.832 1.00 26.55  ? 724  LEU A CB  1 
ATOM   3347 C  CG  . LEU A 1 461 ? -15.737 -58.048 -34.286 1.00 26.16  ? 724  LEU A CG  1 
ATOM   3348 C  CD1 . LEU A 1 461 ? -16.028 -59.043 -33.213 1.00 26.52  ? 724  LEU A CD1 1 
ATOM   3349 C  CD2 . LEU A 1 461 ? -16.951 -57.216 -34.601 1.00 27.80  ? 724  LEU A CD2 1 
ATOM   3350 N  N   . VAL A 1 462 ? -13.012 -54.190 -34.097 1.00 24.78  ? 725  VAL A N   1 
ATOM   3351 C  CA  . VAL A 1 462 ? -12.047 -53.356 -33.348 1.00 24.24  ? 725  VAL A CA  1 
ATOM   3352 C  C   . VAL A 1 462 ? -12.714 -53.026 -32.024 1.00 21.53  ? 725  VAL A C   1 
ATOM   3353 O  O   . VAL A 1 462 ? -13.744 -52.365 -32.029 1.00 23.94  ? 725  VAL A O   1 
ATOM   3354 C  CB  . VAL A 1 462 ? -11.610 -52.114 -34.116 1.00 24.77  ? 725  VAL A CB  1 
ATOM   3355 C  CG1 . VAL A 1 462 ? -10.687 -51.288 -33.205 1.00 24.54  ? 725  VAL A CG1 1 
ATOM   3356 C  CG2 . VAL A 1 462 ? -10.970 -52.498 -35.434 1.00 23.59  ? 725  VAL A CG2 1 
ATOM   3357 N  N   . VAL A 1 463 ? -12.182 -53.605 -30.958 1.00 20.44  ? 726  VAL A N   1 
ATOM   3358 C  CA  . VAL A 1 463 ? -12.857 -53.682 -29.644 1.00 20.54  ? 726  VAL A CA  1 
ATOM   3359 C  C   . VAL A 1 463 ? -12.123 -52.851 -28.608 1.00 19.78  ? 726  VAL A C   1 
ATOM   3360 O  O   . VAL A 1 463 ? -10.885 -52.806 -28.585 1.00 20.29  ? 726  VAL A O   1 
ATOM   3361 C  CB  . VAL A 1 463 ? -13.034 -55.146 -29.198 1.00 21.48  ? 726  VAL A CB  1 
ATOM   3362 C  CG1 . VAL A 1 463 ? -13.877 -55.897 -30.210 1.00 22.05  ? 726  VAL A CG1 1 
ATOM   3363 C  CG2 . VAL A 1 463 ? -11.698 -55.854 -28.975 1.00 20.24  ? 726  VAL A CG2 1 
ATOM   3364 N  N   . PRO A 1 464 ? -12.883 -52.246 -27.686 1.00 20.56  ? 727  PRO A N   1 
ATOM   3365 C  CA  . PRO A 1 464 ? -12.318 -51.493 -26.567 1.00 20.08  ? 727  PRO A CA  1 
ATOM   3366 C  C   . PRO A 1 464 ? -11.879 -52.403 -25.427 1.00 20.80  ? 727  PRO A C   1 
ATOM   3367 O  O   . PRO A 1 464 ? -12.497 -53.421 -25.191 1.00 18.67  ? 727  PRO A O   1 
ATOM   3368 C  CB  . PRO A 1 464 ? -13.485 -50.631 -26.100 1.00 19.44  ? 727  PRO A CB  1 
ATOM   3369 C  CG  . PRO A 1 464 ? -14.694 -51.527 -26.374 1.00 19.19  ? 727  PRO A CG  1 
ATOM   3370 C  CD  . PRO A 1 464 ? -14.369 -52.180 -27.707 1.00 18.69  ? 727  PRO A CD  1 
ATOM   3371 N  N   . CYS A 1 465 ? -10.826 -51.984 -24.716 1.00 19.12  ? 728  CYS A N   1 
ATOM   3372 C  CA  . CYS A 1 465 ? -10.207 -52.804 -23.639 1.00 18.33  ? 728  CYS A CA  1 
ATOM   3373 C  C   . CYS A 1 465 ? -9.575  -51.900 -22.596 1.00 21.43  ? 728  CYS A C   1 
ATOM   3374 O  O   . CYS A 1 465 ? -9.126  -50.788 -22.938 1.00 19.36  ? 728  CYS A O   1 
ATOM   3375 C  CB  . CYS A 1 465 ? -9.205  -53.804 -24.226 1.00 19.44  ? 728  CYS A CB  1 
ATOM   3376 S  SG  . CYS A 1 465 ? -8.755  -55.148 -23.080 1.00 19.06  ? 728  CYS A SG  1 
ATOM   3377 N  N   . ARG A 1 466 ? -9.562  -52.353 -21.345 1.00 21.16  ? 729  ARG A N   1 
ATOM   3378 C  CA  . ARG A 1 466 ? -8.689  -51.776 -20.316 1.00 22.45  ? 729  ARG A CA  1 
ATOM   3379 C  C   . ARG A 1 466 ? -8.399  -52.844 -19.271 1.00 22.43  ? 729  ARG A C   1 
ATOM   3380 O  O   . ARG A 1 466 ? -8.989  -53.937 -19.304 1.00 18.71  ? 729  ARG A O   1 
ATOM   3381 C  CB  . ARG A 1 466 ? -9.281  -50.515 -19.708 1.00 27.43  ? 729  ARG A CB  1 
ATOM   3382 C  CG  . ARG A 1 466 ? -10.613 -50.714 -19.039 1.00 31.23  ? 729  ARG A CG  1 
ATOM   3383 C  CD  . ARG A 1 466 ? -11.309 -49.386 -18.726 1.00 29.13  ? 729  ARG A CD  1 
ATOM   3384 N  NE  . ARG A 1 466 ? -10.725 -48.640 -17.633 1.00 26.84  ? 729  ARG A NE  1 
ATOM   3385 C  CZ  . ARG A 1 466 ? -11.254 -47.502 -17.166 1.00 32.09  ? 729  ARG A CZ  1 
ATOM   3386 N  NH1 . ARG A 1 466 ? -12.414 -47.040 -17.622 1.00 30.71  ? 729  ARG A NH1 1 
ATOM   3387 N  NH2 . ARG A 1 466 ? -10.652 -46.867 -16.203 1.00 30.79  ? 729  ARG A NH2 1 
ATOM   3388 N  N   . ASN A 1 467 ? -7.434  -52.575 -18.402 1.00 22.46  ? 730  ASN A N   1 
ATOM   3389 C  CA  . ASN A 1 467 ? -7.052  -53.572 -17.371 1.00 22.95  ? 730  ASN A CA  1 
ATOM   3390 C  C   . ASN A 1 467 ? -8.350  -54.051 -16.677 1.00 21.31  ? 730  ASN A C   1 
ATOM   3391 O  O   . ASN A 1 467 ? -9.101  -53.220 -16.205 1.00 19.81  ? 730  ASN A O   1 
ATOM   3392 C  CB  . ASN A 1 467 ? -6.005  -53.025 -16.399 1.00 24.31  ? 730  ASN A CB  1 
ATOM   3393 C  CG  . ASN A 1 467 ? -5.717  -54.071 -15.351 1.00 27.95  ? 730  ASN A CG  1 
ATOM   3394 O  OD1 . ASN A 1 467 ? -6.437  -54.156 -14.382 1.00 25.77  ? 730  ASN A OD1 1 
ATOM   3395 N  ND2 . ASN A 1 467 ? -4.755  -54.954 -15.615 1.00 34.62  ? 730  ASN A ND2 1 
ATOM   3396 N  N   . GLN A 1 468 ? -8.513  -55.355 -16.499 1.00 19.60  ? 731  GLN A N   1 
ATOM   3397 C  CA  . GLN A 1 468 ? -9.803  -55.949 -16.077 1.00 19.89  ? 731  GLN A CA  1 
ATOM   3398 C  C   . GLN A 1 468 ? -10.042 -55.647 -14.596 1.00 20.83  ? 731  GLN A C   1 
ATOM   3399 O  O   . GLN A 1 468 ? -11.229 -55.531 -14.187 1.00 19.14  ? 731  GLN A O   1 
ATOM   3400 C  CB  . GLN A 1 468 ? -9.833  -57.419 -16.423 1.00 20.88  ? 731  GLN A CB  1 
ATOM   3401 C  CG  . GLN A 1 468 ? -11.198 -58.034 -16.223 1.00 19.43  ? 731  GLN A CG  1 
ATOM   3402 C  CD  . GLN A 1 468 ? -11.188 -59.522 -16.438 1.00 19.22  ? 731  GLN A CD  1 
ATOM   3403 O  OE1 . GLN A 1 468 ? -11.554 -59.979 -17.506 1.00 21.94  ? 731  GLN A OE1 1 
ATOM   3404 N  NE2 . GLN A 1 468 ? -10.860 -60.277 -15.410 1.00 19.14  ? 731  GLN A NE2 1 
ATOM   3405 N  N   . ASP A 1 469 ? -8.980  -55.411 -13.828 1.00 20.85  ? 732  ASP A N   1 
ATOM   3406 C  CA  . ASP A 1 469 ? -9.161  -55.041 -12.399 1.00 22.86  ? 732  ASP A CA  1 
ATOM   3407 C  C   . ASP A 1 469 ? -9.913  -53.724 -12.335 1.00 23.56  ? 732  ASP A C   1 
ATOM   3408 O  O   . ASP A 1 469 ? -10.714 -53.545 -11.423 1.00 23.97  ? 732  ASP A O   1 
ATOM   3409 C  CB  . ASP A 1 469 ? -7.833  -54.931 -11.640 1.00 23.35  ? 732  ASP A CB  1 
ATOM   3410 C  CG  . ASP A 1 469 ? -7.102  -56.257 -11.466 1.00 26.22  ? 732  ASP A CG  1 
ATOM   3411 O  OD1 . ASP A 1 469 ? -7.719  -57.327 -11.616 1.00 25.22  ? 732  ASP A OD1 1 
ATOM   3412 O  OD2 . ASP A 1 469 ? -5.895  -56.192 -11.203 1.00 26.88  ? 732  ASP A OD2 1 
ATOM   3413 N  N   . GLU A 1 470 ? -9.639  -52.786 -13.247 1.00 20.48  ? 733  GLU A N   1 
ATOM   3414 C  CA  . GLU A 1 470 ? -10.327 -51.474 -13.235 1.00 21.88  ? 733  GLU A CA  1 
ATOM   3415 C  C   . GLU A 1 470 ? -11.820 -51.685 -13.528 1.00 19.96  ? 733  GLU A C   1 
ATOM   3416 O  O   . GLU A 1 470 ? -12.666 -50.980 -12.924 1.00 22.48  ? 733  GLU A O   1 
ATOM   3417 C  CB  . GLU A 1 470 ? -9.815  -50.542 -14.323 1.00 24.59  ? 733  GLU A CB  1 
ATOM   3418 C  CG  . GLU A 1 470 ? -8.317  -50.300 -14.255 1.00 28.14  ? 733  GLU A CG  1 
ATOM   3419 C  CD  . GLU A 1 470 ? -7.698  -49.425 -15.352 1.00 32.62  ? 733  GLU A CD  1 
ATOM   3420 O  OE1 . GLU A 1 470 ? -6.474  -49.313 -15.322 1.00 38.13  ? 733  GLU A OE1 1 
ATOM   3421 O  OE2 . GLU A 1 470 ? -8.408  -48.855 -16.228 1.00 30.20  ? 733  GLU A OE2 1 
ATOM   3422 N  N   . LEU A 1 471 ? -12.150 -52.533 -14.494 1.00 19.68  ? 734  LEU A N   1 
ATOM   3423 C  CA  . LEU A 1 471 ? -13.570 -52.782 -14.873 1.00 19.87  ? 734  LEU A CA  1 
ATOM   3424 C  C   . LEU A 1 471 ? -14.345 -53.424 -13.721 1.00 20.15  ? 734  LEU A C   1 
ATOM   3425 O  O   . LEU A 1 471 ? -15.496 -52.954 -13.373 1.00 19.48  ? 734  LEU A O   1 
ATOM   3426 C  CB  . LEU A 1 471 ? -13.590 -53.638 -16.134 1.00 19.06  ? 734  LEU A CB  1 
ATOM   3427 C  CG  . LEU A 1 471 ? -13.062 -52.897 -17.369 1.00 21.66  ? 734  LEU A CG  1 
ATOM   3428 C  CD1 . LEU A 1 471 ? -12.955 -53.812 -18.580 1.00 20.84  ? 734  LEU A CD1 1 
ATOM   3429 C  CD2 . LEU A 1 471 ? -13.950 -51.702 -17.703 1.00 24.42  ? 734  LEU A CD2 1 
ATOM   3430 N  N   . ILE A 1 472 ? -13.792 -54.473 -13.134 1.00 20.88  ? 735  ILE A N   1 
ATOM   3431 C  CA  . ILE A 1 472 ? -14.468 -55.174 -12.016 1.00 22.00  ? 735  ILE A CA  1 
ATOM   3432 C  C   . ILE A 1 472 ? -14.556 -54.255 -10.773 1.00 21.27  ? 735  ILE A C   1 
ATOM   3433 O  O   . ILE A 1 472 ? -15.632 -54.226 -10.120 1.00 18.64  ? 735  ILE A O   1 
ATOM   3434 C  CB  . ILE A 1 472 ? -13.774 -56.497 -11.737 1.00 20.98  ? 735  ILE A CB  1 
ATOM   3435 C  CG1 . ILE A 1 472 ? -13.940 -57.423 -12.934 1.00 22.39  ? 735  ILE A CG1 1 
ATOM   3436 C  CG2 . ILE A 1 472 ? -14.249 -57.109 -10.420 1.00 21.84  ? 735  ILE A CG2 1 
ATOM   3437 C  CD1 . ILE A 1 472 ? -13.233 -58.724 -12.827 1.00 25.70  ? 735  ILE A CD1 1 
ATOM   3438 N  N   . GLY A 1 473 ? -13.506 -53.506 -10.488 1.00 19.30  ? 736  GLY A N   1 
ATOM   3439 C  CA  . GLY A 1 473 ? -13.483 -52.638 -9.306  1.00 21.42  ? 736  GLY A CA  1 
ATOM   3440 C  C   . GLY A 1 473 ? -14.520 -51.513 -9.434  1.00 22.41  ? 736  GLY A C   1 
ATOM   3441 O  O   . GLY A 1 473 ? -15.188 -51.156 -8.427  1.00 21.90  ? 736  GLY A O   1 
ATOM   3442 N  N   . ARG A 1 474 ? -14.730 -51.010 -10.630 1.00 19.34  ? 737  ARG A N   1 
ATOM   3443 C  CA  . ARG A 1 474 ? -15.746 -49.928 -10.856 1.00 21.48  ? 737  ARG A CA  1 
ATOM   3444 C  C   . ARG A 1 474 ? -17.172 -50.488 -10.763 1.00 22.39  ? 737  ARG A C   1 
ATOM   3445 O  O   . ARG A 1 474 ? -18.037 -49.782 -10.212 1.00 23.27  ? 737  ARG A O   1 
ATOM   3446 C  CB  . ARG A 1 474 ? -15.601 -49.279 -12.244 1.00 24.67  ? 737  ARG A CB  1 
ATOM   3447 C  CG  . ARG A 1 474 ? -14.298 -48.526 -12.447 1.00 37.71  ? 737  ARG A CG  1 
ATOM   3448 C  CD  . ARG A 1 474 ? -13.925 -48.258 -13.919 1.00 46.69  ? 737  ARG A CD  1 
ATOM   3449 N  NE  . ARG A 1 474 ? -14.026 -46.817 -14.095 1.00 56.61  ? 737  ARG A NE  1 
ATOM   3450 C  CZ  . ARG A 1 474 ? -13.157 -45.932 -13.619 1.00 56.34  ? 737  ARG A CZ  1 
ATOM   3451 N  NH1 . ARG A 1 474 ? -13.369 -44.645 -13.824 1.00 77.46  ? 737  ARG A NH1 1 
ATOM   3452 N  NH2 . ARG A 1 474 ? -12.078 -46.317 -12.961 1.00 62.20  ? 737  ARG A NH2 1 
ATOM   3453 N  N   . ALA A 1 475 ? -17.453 -51.687 -11.275 1.00 20.33  ? 738  ALA A N   1 
ATOM   3454 C  CA  . ALA A 1 475 ? -18.818 -52.291 -11.256 1.00 20.28  ? 738  ALA A CA  1 
ATOM   3455 C  C   . ALA A 1 475 ? -19.211 -52.657 -9.800  1.00 22.35  ? 738  ALA A C   1 
ATOM   3456 O  O   . ALA A 1 475 ? -20.421 -52.741 -9.476  1.00 23.33  ? 738  ALA A O   1 
ATOM   3457 C  CB  . ALA A 1 475 ? -18.860 -53.486 -12.188 1.00 19.89  ? 738  ALA A CB  1 
ATOM   3458 N  N   . ARG A 1 476 ? -18.239 -52.781 -8.916  1.00 20.32  ? 739  ARG A N   1 
ATOM   3459 C  CA  . ARG A 1 476 ? -18.444 -53.115 -7.472  1.00 20.99  ? 739  ARG A CA  1 
ATOM   3460 C  C   . ARG A 1 476 ? -18.803 -51.880 -6.626  1.00 23.12  ? 739  ARG A C   1 
ATOM   3461 O  O   . ARG A 1 476 ? -19.079 -52.047 -5.405  1.00 22.45  ? 739  ARG A O   1 
ATOM   3462 C  CB  . ARG A 1 476 ? -17.291 -53.936 -6.904  1.00 21.18  ? 739  ARG A CB  1 
ATOM   3463 C  CG  . ARG A 1 476 ? -17.337 -55.360 -7.442  1.00 22.58  ? 739  ARG A CG  1 
ATOM   3464 C  CD  . ARG A 1 476 ? -16.018 -56.137 -7.289  1.00 24.64  ? 739  ARG A CD  1 
ATOM   3465 N  NE  . ARG A 1 476 ? -15.611 -56.348 -5.925  1.00 22.94  ? 739  ARG A NE  1 
ATOM   3466 C  CZ  . ARG A 1 476 ? -15.250 -57.491 -5.377  1.00 21.98  ? 739  ARG A CZ  1 
ATOM   3467 N  NH1 . ARG A 1 476 ? -15.394 -58.648 -5.986  1.00 23.46  ? 739  ARG A NH1 1 
ATOM   3468 N  NH2 . ARG A 1 476 ? -14.784 -57.474 -4.148  1.00 23.09  ? 739  ARG A NH2 1 
ATOM   3469 N  N   . ILE A 1 477 ? -18.867 -50.706 -7.230  1.00 23.63  ? 740  ILE A N   1 
ATOM   3470 C  CA  . ILE A 1 477 ? -19.087 -49.451 -6.480  1.00 31.44  ? 740  ILE A CA  1 
ATOM   3471 C  C   . ILE A 1 477 ? -20.410 -48.839 -6.924  1.00 34.62  ? 740  ILE A C   1 
ATOM   3472 O  O   . ILE A 1 477 ? -20.720 -48.851 -8.102  1.00 31.69  ? 740  ILE A O   1 
ATOM   3473 C  CB  . ILE A 1 477 ? -17.929 -48.461 -6.704  1.00 31.99  ? 740  ILE A CB  1 
ATOM   3474 C  CG1 . ILE A 1 477 ? -16.664 -48.935 -5.991  1.00 33.70  ? 740  ILE A CG1 1 
ATOM   3475 C  CG2 . ILE A 1 477 ? -18.363 -47.071 -6.268  1.00 38.25  ? 740  ILE A CG2 1 
ATOM   3476 C  CD1 . ILE A 1 477 ? -15.419 -48.141 -6.352  1.00 38.69  ? 740  ILE A CD1 1 
ATOM   3477 N  N   A SER A 1 478 ? -21.177 -48.359 -5.950  0.25 39.51  ? 741  SER A N   1 
ATOM   3478 N  N   B SER A 1 478 ? -21.177 -48.315 -5.964  0.25 39.07  ? 741  SER A N   1 
ATOM   3479 C  CA  A SER A 1 478 ? -22.343 -47.461 -6.149  0.25 43.75  ? 741  SER A CA  1 
ATOM   3480 C  CA  B SER A 1 478 ? -22.391 -47.482 -6.198  0.25 42.60  ? 741  SER A CA  1 
ATOM   3481 C  C   A SER A 1 478 ? -21.989 -46.081 -5.586  0.25 47.45  ? 741  SER A C   1 
ATOM   3482 C  C   B SER A 1 478 ? -22.302 -46.187 -5.379  0.25 47.31  ? 741  SER A C   1 
ATOM   3483 O  O   A SER A 1 478 ? -20.996 -45.968 -4.830  0.25 47.05  ? 741  SER A O   1 
ATOM   3484 O  O   B SER A 1 478 ? -21.817 -46.242 -4.225  0.25 48.03  ? 741  SER A O   1 
ATOM   3485 C  CB  A SER A 1 478 ? -23.576 -48.042 -5.507  0.25 43.15  ? 741  SER A CB  1 
ATOM   3486 C  CB  B SER A 1 478 ? -23.655 -48.253 -5.902  0.25 40.93  ? 741  SER A CB  1 
ATOM   3487 O  OG  A SER A 1 478 ? -24.653 -47.119 -5.526  0.25 42.89  ? 741  SER A OG  1 
ATOM   3488 O  OG  B SER A 1 478 ? -23.500 -49.128 -4.792  0.25 38.72  ? 741  SER A OG  1 
ATOM   3489 N  N   . GLN A 1 479 ? -22.764 -45.064 -5.951  0.50 54.18  ? 742  GLN A N   1 
ATOM   3490 C  CA  . GLN A 1 479 ? -22.669 -43.706 -5.356  0.50 57.62  ? 742  GLN A CA  1 
ATOM   3491 C  C   . GLN A 1 479 ? -24.038 -43.335 -4.780  0.50 57.13  ? 742  GLN A C   1 
ATOM   3492 O  O   . GLN A 1 479 ? -25.044 -43.647 -5.441  0.50 52.23  ? 742  GLN A O   1 
ATOM   3493 C  CB  . GLN A 1 479 ? -22.222 -42.692 -6.411  0.50 62.71  ? 742  GLN A CB  1 
ATOM   3494 C  CG  . GLN A 1 479 ? -20.937 -43.083 -7.129  0.50 68.50  ? 742  GLN A CG  1 
ATOM   3495 C  CD  . GLN A 1 479 ? -19.728 -43.061 -6.223  0.50 70.51  ? 742  GLN A CD  1 
ATOM   3496 O  OE1 . GLN A 1 479 ? -19.759 -42.513 -5.122  0.50 70.75  ? 742  GLN A OE1 1 
ATOM   3497 N  NE2 . GLN A 1 479 ? -18.642 -43.658 -6.688  0.50 71.77  ? 742  GLN A NE2 1 
ATOM   3498 N  N   . GLY A 1 480 ? -24.064 -42.708 -3.598  0.50 58.01  ? 743  GLY A N   1 
ATOM   3499 C  CA  . GLY A 1 480 ? -25.291 -42.180 -2.965  0.50 58.38  ? 743  GLY A CA  1 
ATOM   3500 C  C   . GLY A 1 480 ? -25.936 -43.176 -2.013  0.50 58.38  ? 743  GLY A C   1 
ATOM   3501 O  O   . GLY A 1 480 ? -25.512 -44.348 -1.997  0.50 59.59  ? 743  GLY A O   1 
ATOM   3502 N  N   . ALA A 1 481 ? -26.939 -42.714 -1.257  1.00 59.95  ? 744  ALA A N   1 
ATOM   3503 C  CA  . ALA A 1 481 ? -27.639 -43.482 -0.200  1.00 55.61  ? 744  ALA A CA  1 
ATOM   3504 C  C   . ALA A 1 481 ? -29.034 -43.945 -0.648  1.00 48.65  ? 744  ALA A C   1 
ATOM   3505 O  O   . ALA A 1 481 ? -29.539 -43.487 -1.681  1.00 43.39  ? 744  ALA A O   1 
ATOM   3506 C  CB  . ALA A 1 481 ? -27.775 -42.595 1.027   1.00 58.28  ? 744  ALA A CB  1 
ATOM   3507 N  N   . GLY A 1 482 ? -29.650 -44.797 0.171   1.00 42.34  ? 745  GLY A N   1 
ATOM   3508 C  CA  . GLY A 1 482 ? -31.057 -45.217 0.059   1.00 41.12  ? 745  GLY A CA  1 
ATOM   3509 C  C   . GLY A 1 482 ? -31.242 -46.126 -1.128  1.00 39.61  ? 745  GLY A C   1 
ATOM   3510 O  O   . GLY A 1 482 ? -32.320 -46.076 -1.724  1.00 43.70  ? 745  GLY A O   1 
ATOM   3511 N  N   . TRP A 1 483 ? -30.227 -46.924 -1.504  1.00 31.41  ? 746  TRP A N   1 
ATOM   3512 C  CA  . TRP A 1 483 ? -30.432 -47.937 -2.570  1.00 33.69  ? 746  TRP A CA  1 
ATOM   3513 C  C   . TRP A 1 483 ? -31.223 -49.114 -2.000  1.00 30.89  ? 746  TRP A C   1 
ATOM   3514 O  O   . TRP A 1 483 ? -30.781 -49.794 -1.067  1.00 26.49  ? 746  TRP A O   1 
ATOM   3515 C  CB  . TRP A 1 483 ? -29.120 -48.408 -3.193  1.00 41.19  ? 746  TRP A CB  1 
ATOM   3516 C  CG  . TRP A 1 483 ? -28.409 -47.381 -4.010  1.00 45.32  ? 746  TRP A CG  1 
ATOM   3517 C  CD1 . TRP A 1 483 ? -27.694 -46.315 -3.535  1.00 56.19  ? 746  TRP A CD1 1 
ATOM   3518 C  CD2 . TRP A 1 483 ? -28.261 -47.357 -5.438  1.00 44.75  ? 746  TRP A CD2 1 
ATOM   3519 N  NE1 . TRP A 1 483 ? -27.146 -45.602 -4.569  1.00 53.37  ? 746  TRP A NE1 1 
ATOM   3520 C  CE2 . TRP A 1 483 ? -27.466 -46.225 -5.750  1.00 55.02  ? 746  TRP A CE2 1 
ATOM   3521 C  CE3 . TRP A 1 483 ? -28.708 -48.173 -6.480  1.00 40.76  ? 746  TRP A CE3 1 
ATOM   3522 C  CZ2 . TRP A 1 483 ? -27.126 -45.903 -7.064  1.00 47.96  ? 746  TRP A CZ2 1 
ATOM   3523 C  CZ3 . TRP A 1 483 ? -28.377 -47.848 -7.779  1.00 42.89  ? 746  TRP A CZ3 1 
ATOM   3524 C  CH2 . TRP A 1 483 ? -27.617 -46.716 -8.062  1.00 45.34  ? 746  TRP A CH2 1 
ATOM   3525 N  N   . SER A 1 484 ? -32.368 -49.403 -2.587  1.00 28.80  ? 747  SER A N   1 
ATOM   3526 C  CA  . SER A 1 484 ? -33.072 -50.687 -2.348  1.00 25.99  ? 747  SER A CA  1 
ATOM   3527 C  C   . SER A 1 484 ? -32.243 -51.859 -2.914  1.00 22.98  ? 747  SER A C   1 
ATOM   3528 O  O   . SER A 1 484 ? -31.356 -51.575 -3.745  1.00 24.19  ? 747  SER A O   1 
ATOM   3529 C  CB  . SER A 1 484 ? -34.460 -50.626 -2.939  1.00 24.41  ? 747  SER A CB  1 
ATOM   3530 O  OG  . SER A 1 484 ? -34.424 -50.696 -4.356  1.00 24.34  ? 747  SER A OG  1 
ATOM   3531 N  N   . LEU A 1 485 ? -32.587 -53.119 -2.573  1.00 22.79  ? 748  LEU A N   1 
ATOM   3532 C  CA  . LEU A 1 485 ? -31.976 -54.325 -3.199  1.00 23.98  ? 748  LEU A CA  1 
ATOM   3533 C  C   . LEU A 1 485 ? -32.300 -54.359 -4.700  1.00 25.87  ? 748  LEU A C   1 
ATOM   3534 O  O   . LEU A 1 485 ? -31.413 -54.592 -5.509  1.00 21.99  ? 748  LEU A O   1 
ATOM   3535 C  CB  . LEU A 1 485 ? -32.455 -55.601 -2.516  1.00 25.49  ? 748  LEU A CB  1 
ATOM   3536 C  CG  . LEU A 1 485 ? -31.825 -56.865 -3.083  1.00 27.94  ? 748  LEU A CG  1 
ATOM   3537 C  CD1 . LEU A 1 485 ? -30.293 -56.743 -3.101  1.00 30.78  ? 748  LEU A CD1 1 
ATOM   3538 C  CD2 . LEU A 1 485 ? -32.253 -58.075 -2.280  1.00 29.50  ? 748  LEU A CD2 1 
ATOM   3539 N  N   . ARG A 1 486 ? -33.548 -54.044 -5.078  1.00 23.86  ? 749  ARG A N   1 
ATOM   3540 C  CA  . ARG A 1 486 ? -33.927 -53.986 -6.503  1.00 25.25  ? 749  ARG A CA  1 
ATOM   3541 C  C   . ARG A 1 486 ? -33.074 -52.942 -7.245  1.00 23.19  ? 749  ARG A C   1 
ATOM   3542 O  O   . ARG A 1 486 ? -32.617 -53.237 -8.352  1.00 24.28  ? 749  ARG A O   1 
ATOM   3543 C  CB  . ARG A 1 486 ? -35.430 -53.699 -6.652  1.00 25.51  ? 749  ARG A CB  1 
ATOM   3544 C  CG  . ARG A 1 486 ? -35.823 -53.410 -8.092  1.00 27.58  ? 749  ARG A CG  1 
ATOM   3545 C  CD  . ARG A 1 486 ? -37.333 -53.483 -8.142  1.00 28.94  ? 749  ARG A CD  1 
ATOM   3546 N  NE  . ARG A 1 486 ? -37.845 -53.383 -9.502  1.00 27.67  ? 749  ARG A NE  1 
ATOM   3547 C  CZ  . ARG A 1 486 ? -38.987 -53.923 -9.871  1.00 27.98  ? 749  ARG A CZ  1 
ATOM   3548 N  NH1 . ARG A 1 486 ? -39.665 -54.629 -8.983  1.00 25.39  ? 749  ARG A NH1 1 
ATOM   3549 N  NH2 . ARG A 1 486 ? -39.427 -53.793 -11.118 1.00 28.08  ? 749  ARG A NH2 1 
ATOM   3550 N  N   . GLU A 1 487 ? -32.925 -51.726 -6.733  1.00 22.57  ? 750  GLU A N   1 
ATOM   3551 C  CA  . GLU A 1 487 ? -32.158 -50.683 -7.448  1.00 24.42  ? 750  GLU A CA  1 
ATOM   3552 C  C   . GLU A 1 487 ? -30.661 -51.095 -7.551  1.00 24.09  ? 750  GLU A C   1 
ATOM   3553 O  O   . GLU A 1 487 ? -30.040 -50.888 -8.627  1.00 21.73  ? 750  GLU A O   1 
ATOM   3554 C  CB  . GLU A 1 487 ? -32.233 -49.337 -6.731  1.00 29.58  ? 750  GLU A CB  1 
ATOM   3555 C  CG  . GLU A 1 487 ? -31.901 -48.203 -7.674  1.00 40.92  ? 750  GLU A CG  1 
ATOM   3556 C  CD  . GLU A 1 487 ? -31.775 -46.807 -7.076  1.00 49.02  ? 750  GLU A CD  1 
ATOM   3557 O  OE1 . GLU A 1 487 ? -31.920 -46.662 -5.825  1.00 52.04  ? 750  GLU A OE1 1 
ATOM   3558 O  OE2 . GLU A 1 487 ? -31.568 -45.863 -7.877  1.00 48.32  ? 750  GLU A OE2 1 
ATOM   3559 N  N   . THR A 1 488 ? -30.131 -51.721 -6.510  1.00 22.86  ? 751  THR A N   1 
ATOM   3560 C  CA  . THR A 1 488 ? -28.718 -52.233 -6.518  1.00 21.42  ? 751  THR A CA  1 
ATOM   3561 C  C   . THR A 1 488 ? -28.585 -53.330 -7.597  1.00 22.76  ? 751  THR A C   1 
ATOM   3562 O  O   . THR A 1 488 ? -27.598 -53.306 -8.406  1.00 23.65  ? 751  THR A O   1 
ATOM   3563 C  CB  . THR A 1 488 ? -28.353 -52.785 -5.151  1.00 22.11  ? 751  THR A CB  1 
ATOM   3564 O  OG1 . THR A 1 488 ? -28.581 -51.777 -4.164  1.00 24.91  ? 751  THR A OG1 1 
ATOM   3565 C  CG2 . THR A 1 488 ? -26.934 -53.327 -5.110  1.00 22.08  ? 751  THR A CG2 1 
ATOM   3566 N  N   . ALA A 1 489 ? -29.564 -54.241 -7.703  1.00 21.92  ? 752  ALA A N   1 
ATOM   3567 C  CA  . ALA A 1 489 ? -29.575 -55.310 -8.721  1.00 21.84  ? 752  ALA A CA  1 
ATOM   3568 C  C   . ALA A 1 489 ? -29.627 -54.706 -10.131 1.00 26.32  ? 752  ALA A C   1 
ATOM   3569 O  O   . ALA A 1 489 ? -28.957 -55.250 -11.033 1.00 22.10  ? 752  ALA A O   1 
ATOM   3570 C  CB  . ALA A 1 489 ? -30.735 -56.258 -8.480  1.00 21.65  ? 752  ALA A CB  1 
ATOM   3571 N  N   . CYS A 1 490 ? -30.457 -53.666 -10.345 1.00 22.07  ? 753  CYS A N   1 
ATOM   3572 C  CA  . CYS A 1 490 ? -30.637 -53.072 -11.683 1.00 20.49  ? 753  CYS A CA  1 
ATOM   3573 C  C   . CYS A 1 490 ? -29.340 -52.320 -12.074 1.00 20.45  ? 753  CYS A C   1 
ATOM   3574 O  O   . CYS A 1 490 ? -29.020 -52.279 -13.284 1.00 20.33  ? 753  CYS A O   1 
ATOM   3575 C  CB  . CYS A 1 490 ? -31.838 -52.135 -11.680 1.00 21.13  ? 753  CYS A CB  1 
ATOM   3576 S  SG  . CYS A 1 490 ? -33.367 -53.108 -11.606 1.00 25.86  ? 753  CYS A SG  1 
ATOM   3577 N  N   . LEU A 1 491 ? -28.627 -51.723 -11.119 1.00 19.40  ? 754  LEU A N   1 
ATOM   3578 C  CA  . LEU A 1 491 ? -27.291 -51.129 -11.415 1.00 20.87  ? 754  LEU A CA  1 
ATOM   3579 C  C   . LEU A 1 491 ? -26.271 -52.229 -11.756 1.00 22.01  ? 754  LEU A C   1 
ATOM   3580 O  O   . LEU A 1 491 ? -25.515 -52.049 -12.681 1.00 21.85  ? 754  LEU A O   1 
ATOM   3581 C  CB  . LEU A 1 491 ? -26.816 -50.303 -10.220 1.00 24.71  ? 754  LEU A CB  1 
ATOM   3582 C  CG  . LEU A 1 491 ? -25.434 -49.666 -10.407 1.00 25.22  ? 754  LEU A CG  1 
ATOM   3583 C  CD1 . LEU A 1 491 ? -25.416 -48.763 -11.626 1.00 25.75  ? 754  LEU A CD1 1 
ATOM   3584 C  CD2 . LEU A 1 491 ? -24.966 -48.942 -9.153  1.00 27.72  ? 754  LEU A CD2 1 
ATOM   3585 N  N   . GLY A 1 492 ? -26.315 -53.384 -11.090 1.00 21.24  ? 755  GLY A N   1 
ATOM   3586 C  CA  . GLY A 1 492 ? -25.424 -54.481 -11.482 1.00 20.14  ? 755  GLY A CA  1 
ATOM   3587 C  C   . GLY A 1 492 ? -25.716 -54.965 -12.884 1.00 21.67  ? 755  GLY A C   1 
ATOM   3588 O  O   . GLY A 1 492 ? -24.797 -55.248 -13.665 1.00 20.16  ? 755  GLY A O   1 
ATOM   3589 N  N   . LYS A 1 493 ? -27.010 -55.031 -13.241 1.00 19.91  ? 756  LYS A N   1 
ATOM   3590 C  CA  . LYS A 1 493 ? -27.455 -55.444 -14.577 1.00 19.60  ? 756  LYS A CA  1 
ATOM   3591 C  C   . LYS A 1 493 ? -26.939 -54.453 -15.617 1.00 19.02  ? 756  LYS A C   1 
ATOM   3592 O  O   . LYS A 1 493 ? -26.610 -54.923 -16.726 1.00 22.50  ? 756  LYS A O   1 
ATOM   3593 C  CB  . LYS A 1 493 ? -29.007 -55.578 -14.603 1.00 20.69  ? 756  LYS A CB  1 
ATOM   3594 C  CG  . LYS A 1 493 ? -29.541 -56.108 -15.920 1.00 22.28  ? 756  LYS A CG  1 
ATOM   3595 C  CD  . LYS A 1 493 ? -31.018 -56.513 -15.789 1.00 21.44  ? 756  LYS A CD  1 
ATOM   3596 C  CE  . LYS A 1 493 ? -31.606 -56.948 -17.098 1.00 25.94  ? 756  LYS A CE  1 
ATOM   3597 N  NZ  . LYS A 1 493 ? -32.964 -57.524 -16.897 1.00 26.62  ? 756  LYS A NZ  1 
ATOM   3598 N  N   . SER A 1 494 ? -26.957 -53.149 -15.360 1.00 19.54  ? 757  SER A N   1 
ATOM   3599 C  CA  . SER A 1 494 ? -26.395 -52.131 -16.275 1.00 21.98  ? 757  SER A CA  1 
ATOM   3600 C  C   . SER A 1 494 ? -24.903 -52.454 -16.543 1.00 21.69  ? 757  SER A C   1 
ATOM   3601 O  O   . SER A 1 494 ? -24.533 -52.463 -17.747 1.00 19.27  ? 757  SER A O   1 
ATOM   3602 C  CB  . SER A 1 494 ? -26.489 -50.714 -15.789 1.00 25.80  ? 757  SER A CB  1 
ATOM   3603 O  OG  . SER A 1 494 ? -27.837 -50.400 -15.446 1.00 34.25  ? 757  SER A OG  1 
ATOM   3604 N  N   . TYR A 1 495 ? -24.101 -52.720 -15.527 1.00 19.36  ? 758  TYR A N   1 
ATOM   3605 C  CA  . TYR A 1 495 ? -22.653 -53.069 -15.742 1.00 21.25  ? 758  TYR A CA  1 
ATOM   3606 C  C   . TYR A 1 495 ? -22.563 -54.357 -16.561 1.00 19.01  ? 758  TYR A C   1 
ATOM   3607 O  O   . TYR A 1 495 ? -21.763 -54.447 -17.527 1.00 20.95  ? 758  TYR A O   1 
ATOM   3608 C  CB  . TYR A 1 495 ? -21.878 -53.175 -14.423 1.00 21.73  ? 758  TYR A CB  1 
ATOM   3609 C  CG  . TYR A 1 495 ? -21.411 -51.838 -13.927 1.00 23.94  ? 758  TYR A CG  1 
ATOM   3610 C  CD1 . TYR A 1 495 ? -20.291 -51.240 -14.498 1.00 23.35  ? 758  TYR A CD1 1 
ATOM   3611 C  CD2 . TYR A 1 495 ? -22.078 -51.163 -12.920 1.00 25.95  ? 758  TYR A CD2 1 
ATOM   3612 C  CE1 . TYR A 1 495 ? -19.866 -49.996 -14.093 1.00 23.63  ? 758  TYR A CE1 1 
ATOM   3613 C  CE2 . TYR A 1 495 ? -21.647 -49.907 -12.501 1.00 28.16  ? 758  TYR A CE2 1 
ATOM   3614 C  CZ  . TYR A 1 495 ? -20.550 -49.321 -13.115 1.00 28.33  ? 758  TYR A CZ  1 
ATOM   3615 O  OH  . TYR A 1 495 ? -20.109 -48.084 -12.750 1.00 29.40  ? 758  TYR A OH  1 
ATOM   3616 N  N   . ALA A 1 496 ? -23.352 -55.370 -16.198 1.00 20.63  ? 759  ALA A N   1 
ATOM   3617 C  CA  . ALA A 1 496 ? -23.318 -56.682 -16.885 1.00 18.29  ? 759  ALA A CA  1 
ATOM   3618 C  C   . ALA A 1 496 ? -23.625 -56.477 -18.358 1.00 19.32  ? 759  ALA A C   1 
ATOM   3619 O  O   . ALA A 1 496 ? -22.924 -57.059 -19.201 1.00 19.99  ? 759  ALA A O   1 
ATOM   3620 C  CB  . ALA A 1 496 ? -24.261 -57.669 -16.245 1.00 20.01  ? 759  ALA A CB  1 
ATOM   3621 N  N   . GLN A 1 497 ? -24.701 -55.764 -18.704 1.00 17.87  ? 760  GLN A N   1 
ATOM   3622 C  CA  . GLN A 1 497 ? -25.021 -55.529 -20.134 1.00 20.64  ? 760  GLN A CA  1 
ATOM   3623 C  C   . GLN A 1 497 ? -23.928 -54.673 -20.839 1.00 20.64  ? 760  GLN A C   1 
ATOM   3624 O  O   . GLN A 1 497 ? -23.623 -54.950 -22.061 1.00 19.42  ? 760  GLN A O   1 
ATOM   3625 C  CB  . GLN A 1 497 ? -26.455 -55.005 -20.273 1.00 24.91  ? 760  GLN A CB  1 
ATOM   3626 C  CG  . GLN A 1 497 ? -27.473 -56.020 -19.747 1.00 23.76  ? 760  GLN A CG  1 
ATOM   3627 C  CD  . GLN A 1 497 ? -28.930 -55.758 -20.108 1.00 26.36  ? 760  GLN A CD  1 
ATOM   3628 O  OE1 . GLN A 1 497 ? -29.748 -56.676 -20.056 1.00 25.59  ? 760  GLN A OE1 1 
ATOM   3629 N  NE2 . GLN A 1 497 ? -29.251 -54.544 -20.479 1.00 24.10  ? 760  GLN A NE2 1 
ATOM   3630 N  N   . MET A 1 498 ? -23.311 -53.709 -20.162 1.00 19.65  ? 761  MET A N   1 
ATOM   3631 C  CA  . MET A 1 498 ? -22.185 -52.976 -20.801 1.00 21.67  ? 761  MET A CA  1 
ATOM   3632 C  C   . MET A 1 498 ? -21.056 -53.961 -21.123 1.00 18.84  ? 761  MET A C   1 
ATOM   3633 O  O   . MET A 1 498 ? -20.459 -53.914 -22.234 1.00 20.99  ? 761  MET A O   1 
ATOM   3634 C  CB  . MET A 1 498 ? -21.674 -51.845 -19.914 1.00 22.10  ? 761  MET A CB  1 
ATOM   3635 C  CG  . MET A 1 498 ? -20.403 -51.159 -20.492 1.00 26.04  ? 761  MET A CG  1 
ATOM   3636 S  SD  . MET A 1 498 ? -19.872 -49.891 -19.343 1.00 34.50  ? 761  MET A SD  1 
ATOM   3637 C  CE  . MET A 1 498 ? -18.912 -50.911 -18.239 1.00 33.35  ? 761  MET A CE  1 
ATOM   3638 N  N   . TRP A 1 499 ? -20.769 -54.866 -20.214 1.00 18.09  ? 762  TRP A N   1 
ATOM   3639 C  CA  . TRP A 1 499 ? -19.680 -55.852 -20.415 1.00 17.69  ? 762  TRP A CA  1 
ATOM   3640 C  C   . TRP A 1 499 ? -20.019 -56.757 -21.623 1.00 21.83  ? 762  TRP A C   1 
ATOM   3641 O  O   . TRP A 1 499 ? -19.130 -57.035 -22.413 1.00 21.13  ? 762  TRP A O   1 
ATOM   3642 C  CB  . TRP A 1 499 ? -19.487 -56.687 -19.142 1.00 18.92  ? 762  TRP A CB  1 
ATOM   3643 C  CG  . TRP A 1 499 ? -18.828 -55.995 -17.998 1.00 18.08  ? 762  TRP A CG  1 
ATOM   3644 C  CD1 . TRP A 1 499 ? -18.315 -54.745 -17.980 1.00 19.92  ? 762  TRP A CD1 1 
ATOM   3645 C  CD2 . TRP A 1 499 ? -18.645 -56.522 -16.672 1.00 20.17  ? 762  TRP A CD2 1 
ATOM   3646 N  NE1 . TRP A 1 499 ? -17.935 -54.412 -16.719 1.00 20.62  ? 762  TRP A NE1 1 
ATOM   3647 C  CE2 . TRP A 1 499 ? -18.031 -55.511 -15.920 1.00 18.65  ? 762  TRP A CE2 1 
ATOM   3648 C  CE3 . TRP A 1 499 ? -18.966 -57.726 -16.042 1.00 21.22  ? 762  TRP A CE3 1 
ATOM   3649 C  CZ2 . TRP A 1 499 ? -17.721 -55.658 -14.580 1.00 19.13  ? 762  TRP A CZ2 1 
ATOM   3650 C  CZ3 . TRP A 1 499 ? -18.668 -57.872 -14.701 1.00 21.01  ? 762  TRP A CZ3 1 
ATOM   3651 C  CH2 . TRP A 1 499 ? -18.052 -56.854 -13.992 1.00 21.02  ? 762  TRP A CH2 1 
ATOM   3652 N  N   A SER A 1 500 ? -21.279 -57.211 -21.741 0.25 20.33  ? 763  SER A N   1 
ATOM   3653 N  N   B SER A 1 500 ? -21.281 -57.212 -21.756 0.25 20.49  ? 763  SER A N   1 
ATOM   3654 C  CA  A SER A 1 500 ? -21.720 -58.083 -22.859 0.25 20.40  ? 763  SER A CA  1 
ATOM   3655 C  CA  B SER A 1 500 ? -21.700 -58.102 -22.872 0.25 20.65  ? 763  SER A CA  1 
ATOM   3656 C  C   A SER A 1 500 ? -21.562 -57.359 -24.196 0.25 19.94  ? 763  SER A C   1 
ATOM   3657 C  C   B SER A 1 500 ? -21.607 -57.367 -24.211 0.25 20.00  ? 763  SER A C   1 
ATOM   3658 O  O   A SER A 1 500 ? -21.272 -58.037 -25.183 0.25 22.00  ? 763  SER A O   1 
ATOM   3659 O  O   B SER A 1 500 ? -21.436 -58.049 -25.226 0.25 21.41  ? 763  SER A O   1 
ATOM   3660 C  CB  A SER A 1 500 ? -23.132 -58.567 -22.676 0.25 20.85  ? 763  SER A CB  1 
ATOM   3661 C  CB  B SER A 1 500 ? -23.086 -58.690 -22.688 0.25 21.32  ? 763  SER A CB  1 
ATOM   3662 O  OG  A SER A 1 500 ? -23.259 -59.226 -21.428 0.25 22.19  ? 763  SER A OG  1 
ATOM   3663 O  OG  B SER A 1 500 ? -24.087 -57.688 -22.761 0.25 23.23  ? 763  SER A OG  1 
ATOM   3664 N  N   . LEU A 1 501 ? -21.757 -56.041 -24.228 1.00 20.81  ? 764  LEU A N   1 
ATOM   3665 C  CA  . LEU A 1 501 ? -21.698 -55.264 -25.484 1.00 22.42  ? 764  LEU A CA  1 
ATOM   3666 C  C   . LEU A 1 501 ? -20.266 -54.801 -25.838 1.00 24.51  ? 764  LEU A C   1 
ATOM   3667 O  O   . LEU A 1 501 ? -19.921 -54.738 -27.020 1.00 26.77  ? 764  LEU A O   1 
ATOM   3668 C  CB  . LEU A 1 501 ? -22.665 -54.094 -25.317 1.00 27.74  ? 764  LEU A CB  1 
ATOM   3669 C  CG  . LEU A 1 501 ? -23.085 -53.423 -26.613 1.00 38.80  ? 764  LEU A CG  1 
ATOM   3670 C  CD1 . LEU A 1 501 ? -23.550 -54.446 -27.651 1.00 44.28  ? 764  LEU A CD1 1 
ATOM   3671 C  CD2 . LEU A 1 501 ? -24.199 -52.419 -26.315 1.00 45.29  ? 764  LEU A CD2 1 
ATOM   3672 N  N   . MET A 1 502 ? -19.488 -54.392 -24.869 1.00 21.69  ? 765  MET A N   1 
ATOM   3673 C  CA  . MET A 1 502 ? -18.201 -53.705 -25.102 1.00 21.63  ? 765  MET A CA  1 
ATOM   3674 C  C   . MET A 1 502 ? -17.039 -54.680 -24.811 1.00 21.90  ? 765  MET A C   1 
ATOM   3675 O  O   . MET A 1 502 ? -16.036 -54.532 -25.465 1.00 19.89  ? 765  MET A O   1 
ATOM   3676 C  CB  . MET A 1 502 ? -18.060 -52.485 -24.186 1.00 24.13  ? 765  MET A CB  1 
ATOM   3677 C  CG  . MET A 1 502 ? -19.114 -51.355 -24.430 1.00 25.01  ? 765  MET A CG  1 
ATOM   3678 S  SD  . MET A 1 502 ? -19.066 -50.738 -26.139 1.00 32.87  ? 765  MET A SD  1 
ATOM   3679 C  CE  . MET A 1 502 ? -20.319 -51.666 -26.966 1.00 40.47  ? 765  MET A CE  1 
ATOM   3680 N  N   . TYR A 1 503 ? -17.163 -55.566 -23.824 1.00 20.07  ? 766  TYR A N   1 
ATOM   3681 C  CA  . TYR A 1 503 ? -16.018 -56.339 -23.274 1.00 20.22  ? 766  TYR A CA  1 
ATOM   3682 C  C   . TYR A 1 503 ? -16.279 -57.855 -23.371 1.00 20.94  ? 766  TYR A C   1 
ATOM   3683 O  O   . TYR A 1 503 ? -15.666 -58.604 -22.599 1.00 19.52  ? 766  TYR A O   1 
ATOM   3684 C  CB  . TYR A 1 503 ? -15.751 -55.878 -21.841 1.00 21.29  ? 766  TYR A CB  1 
ATOM   3685 C  CG  . TYR A 1 503 ? -15.537 -54.380 -21.652 1.00 21.97  ? 766  TYR A CG  1 
ATOM   3686 C  CD1 . TYR A 1 503 ? -14.542 -53.683 -22.338 1.00 21.29  ? 766  TYR A CD1 1 
ATOM   3687 C  CD2 . TYR A 1 503 ? -16.340 -53.641 -20.809 1.00 24.71  ? 766  TYR A CD2 1 
ATOM   3688 C  CE1 . TYR A 1 503 ? -14.344 -52.313 -22.148 1.00 21.94  ? 766  TYR A CE1 1 
ATOM   3689 C  CE2 . TYR A 1 503 ? -16.232 -52.260 -20.698 1.00 25.38  ? 766  TYR A CE2 1 
ATOM   3690 C  CZ  . TYR A 1 503 ? -15.182 -51.599 -21.304 1.00 23.52  ? 766  TYR A CZ  1 
ATOM   3691 O  OH  . TYR A 1 503 ? -15.046 -50.257 -21.074 1.00 24.15  ? 766  TYR A OH  1 
ATOM   3692 N  N   . PHE A 1 504 ? -17.112 -58.280 -24.338 1.00 20.91  ? 767  PHE A N   1 
ATOM   3693 C  CA  . PHE A 1 504 ? -17.516 -59.685 -24.605 1.00 21.31  ? 767  PHE A CA  1 
ATOM   3694 C  C   . PHE A 1 504 ? -16.270 -60.543 -24.841 1.00 21.33  ? 767  PHE A C   1 
ATOM   3695 O  O   . PHE A 1 504 ? -16.316 -61.781 -24.625 1.00 20.07  ? 767  PHE A O   1 
ATOM   3696 C  CB  . PHE A 1 504 ? -18.443 -59.779 -25.824 1.00 21.94  ? 767  PHE A CB  1 
ATOM   3697 C  CG  . PHE A 1 504 ? -17.935 -59.037 -27.027 1.00 20.29  ? 767  PHE A CG  1 
ATOM   3698 C  CD1 . PHE A 1 504 ? -18.263 -57.709 -27.227 1.00 21.51  ? 767  PHE A CD1 1 
ATOM   3699 C  CD2 . PHE A 1 504 ? -17.122 -59.659 -27.950 1.00 20.07  ? 767  PHE A CD2 1 
ATOM   3700 C  CE1 . PHE A 1 504 ? -17.764 -57.018 -28.315 1.00 20.35  ? 767  PHE A CE1 1 
ATOM   3701 C  CE2 . PHE A 1 504 ? -16.627 -58.956 -29.017 1.00 19.29  ? 767  PHE A CE2 1 
ATOM   3702 C  CZ  . PHE A 1 504 ? -16.943 -57.647 -29.193 1.00 20.93  ? 767  PHE A CZ  1 
ATOM   3703 N  N   . HIS A 1 505 ? -15.206 -59.887 -25.320 1.00 21.54  ? 768  HIS A N   1 
ATOM   3704 C  CA  . HIS A 1 505 ? -13.913 -60.523 -25.721 1.00 20.74  ? 768  HIS A CA  1 
ATOM   3705 C  C   . HIS A 1 505 ? -13.050 -60.896 -24.509 1.00 21.24  ? 768  HIS A C   1 
ATOM   3706 O  O   . HIS A 1 505 ? -11.988 -61.560 -24.702 1.00 20.58  ? 768  HIS A O   1 
ATOM   3707 C  CB  . HIS A 1 505 ? -13.211 -59.640 -26.753 1.00 20.18  ? 768  HIS A CB  1 
ATOM   3708 C  CG  . HIS A 1 505 ? -13.053 -58.226 -26.303 1.00 21.10  ? 768  HIS A CG  1 
ATOM   3709 N  ND1 . HIS A 1 505 ? -11.988 -57.810 -25.556 1.00 20.71  ? 768  HIS A ND1 1 
ATOM   3710 C  CD2 . HIS A 1 505 ? -13.890 -57.167 -26.421 1.00 22.31  ? 768  HIS A CD2 1 
ATOM   3711 C  CE1 . HIS A 1 505 ? -12.149 -56.524 -25.287 1.00 20.71  ? 768  HIS A CE1 1 
ATOM   3712 N  NE2 . HIS A 1 505 ? -13.334 -56.101 -25.788 1.00 20.06  ? 768  HIS A NE2 1 
ATOM   3713 N  N   . ARG A 1 506 ? -13.428 -60.487 -23.288 1.00 17.85  ? 769  ARG A N   1 
ATOM   3714 C  CA  . ARG A 1 506 ? -12.723 -60.816 -22.019 1.00 19.03  ? 769  ARG A CA  1 
ATOM   3715 C  C   . ARG A 1 506 ? -13.468 -62.005 -21.399 1.00 20.56  ? 769  ARG A C   1 
ATOM   3716 O  O   . ARG A 1 506 ? -14.675 -61.852 -21.144 1.00 20.65  ? 769  ARG A O   1 
ATOM   3717 C  CB  . ARG A 1 506 ? -12.695 -59.599 -21.085 1.00 18.88  ? 769  ARG A CB  1 
ATOM   3718 C  CG  . ARG A 1 506 ? -12.214 -58.309 -21.738 1.00 20.45  ? 769  ARG A CG  1 
ATOM   3719 C  CD  . ARG A 1 506 ? -10.832 -58.387 -22.412 1.00 19.75  ? 769  ARG A CD  1 
ATOM   3720 N  NE  . ARG A 1 506 ? -9.889  -58.931 -21.459 1.00 19.58  ? 769  ARG A NE  1 
ATOM   3721 C  CZ  . ARG A 1 506 ? -9.361  -58.290 -20.451 1.00 20.96  ? 769  ARG A CZ  1 
ATOM   3722 N  NH1 . ARG A 1 506 ? -8.645  -58.951 -19.546 1.00 18.97  ? 769  ARG A NH1 1 
ATOM   3723 N  NH2 . ARG A 1 506 ? -9.523  -56.989 -20.327 1.00 20.28  ? 769  ARG A NH2 1 
ATOM   3724 N  N   . ARG A 1 507 ? -12.813 -63.173 -21.298 1.00 20.56  ? 770  ARG A N   1 
ATOM   3725 C  CA  . ARG A 1 507 ? -13.428 -64.416 -20.802 1.00 21.40  ? 770  ARG A CA  1 
ATOM   3726 C  C   . ARG A 1 507 ? -14.132 -64.173 -19.468 1.00 19.43  ? 770  ARG A C   1 
ATOM   3727 O  O   . ARG A 1 507 ? -15.285 -64.618 -19.339 1.00 21.44  ? 770  ARG A O   1 
ATOM   3728 C  CB  . ARG A 1 507 ? -12.391 -65.536 -20.643 1.00 23.87  ? 770  ARG A CB  1 
ATOM   3729 C  CG  . ARG A 1 507 ? -11.834 -66.058 -21.954 1.00 23.16  ? 770  ARG A CG  1 
ATOM   3730 C  CD  . ARG A 1 507 ? -10.523 -66.864 -21.772 1.00 25.96  ? 770  ARG A CD  1 
ATOM   3731 N  NE  . ARG A 1 507 ? -10.173 -67.417 -23.071 1.00 24.83  ? 770  ARG A NE  1 
ATOM   3732 C  CZ  . ARG A 1 507 ? -9.675  -66.698 -24.057 1.00 26.86  ? 770  ARG A CZ  1 
ATOM   3733 N  NH1 . ARG A 1 507 ? -9.353  -65.420 -23.888 1.00 24.60  ? 770  ARG A NH1 1 
ATOM   3734 N  NH2 . ARG A 1 507 ? -9.406  -67.269 -25.211 1.00 25.35  ? 770  ARG A NH2 1 
ATOM   3735 N  N   . ASP A 1 508 ? -13.495 -63.514 -18.519 1.00 19.10  ? 771  ASP A N   1 
ATOM   3736 C  CA  . ASP A 1 508 ? -14.040 -63.393 -17.153 1.00 20.33  ? 771  ASP A CA  1 
ATOM   3737 C  C   . ASP A 1 508 ? -15.292 -62.481 -17.198 1.00 20.33  ? 771  ASP A C   1 
ATOM   3738 O  O   . ASP A 1 508 ? -16.234 -62.717 -16.429 1.00 20.52  ? 771  ASP A O   1 
ATOM   3739 C  CB  . ASP A 1 508 ? -13.039 -62.821 -16.164 1.00 19.80  ? 771  ASP A CB  1 
ATOM   3740 C  CG  . ASP A 1 508 ? -11.796 -63.689 -15.971 1.00 21.41  ? 771  ASP A CG  1 
ATOM   3741 O  OD1 . ASP A 1 508 ? -11.845 -64.862 -16.398 1.00 19.36  ? 771  ASP A OD1 1 
ATOM   3742 O  OD2 . ASP A 1 508 ? -10.792 -63.149 -15.405 1.00 19.29  ? 771  ASP A OD2 1 
ATOM   3743 N  N   . LEU A 1 509 ? -15.294 -61.469 -18.069 1.00 19.72  ? 772  LEU A N   1 
ATOM   3744 C  CA  . LEU A 1 509 ? -16.414 -60.496 -18.054 1.00 19.88  ? 772  LEU A CA  1 
ATOM   3745 C  C   . LEU A 1 509 ? -17.591 -61.113 -18.790 1.00 21.30  ? 772  LEU A C   1 
ATOM   3746 O  O   . LEU A 1 509 ? -18.725 -60.795 -18.405 1.00 20.49  ? 772  LEU A O   1 
ATOM   3747 C  CB  . LEU A 1 509 ? -15.989 -59.153 -18.636 1.00 19.86  ? 772  LEU A CB  1 
ATOM   3748 C  CG  . LEU A 1 509 ? -14.819 -58.440 -17.923 1.00 19.81  ? 772  LEU A CG  1 
ATOM   3749 C  CD1 . LEU A 1 509 ? -14.627 -57.037 -18.478 1.00 20.93  ? 772  LEU A CD1 1 
ATOM   3750 C  CD2 . LEU A 1 509 ? -15.057 -58.394 -16.397 1.00 20.04  ? 772  LEU A CD2 1 
ATOM   3751 N  N   . ARG A 1 510 ? -17.381 -61.894 -19.857 1.00 21.23  ? 773  ARG A N   1 
ATOM   3752 C  CA  . ARG A 1 510 ? -18.578 -62.483 -20.518 1.00 22.62  ? 773  ARG A CA  1 
ATOM   3753 C  C   . ARG A 1 510 ? -19.249 -63.428 -19.522 1.00 23.01  ? 773  ARG A C   1 
ATOM   3754 O  O   . ARG A 1 510 ? -20.512 -63.479 -19.489 1.00 20.95  ? 773  ARG A O   1 
ATOM   3755 C  CB  . ARG A 1 510 ? -18.252 -63.173 -21.834 1.00 22.36  ? 773  ARG A CB  1 
ATOM   3756 C  CG  . ARG A 1 510 ? -19.489 -63.486 -22.674 1.00 24.89  ? 773  ARG A CG  1 
ATOM   3757 C  CD  . ARG A 1 510 ? -19.217 -64.396 -23.842 1.00 23.10  ? 773  ARG A CD  1 
ATOM   3758 N  NE  . ARG A 1 510 ? -18.278 -63.854 -24.776 1.00 22.59  ? 773  ARG A NE  1 
ATOM   3759 C  CZ  . ARG A 1 510 ? -18.128 -64.273 -26.036 1.00 23.58  ? 773  ARG A CZ  1 
ATOM   3760 N  NH1 . ARG A 1 510 ? -18.921 -65.208 -26.546 1.00 25.04  ? 773  ARG A NH1 1 
ATOM   3761 N  NH2 . ARG A 1 510 ? -17.235 -63.714 -26.820 1.00 23.57  ? 773  ARG A NH2 1 
ATOM   3762 N  N   . LEU A 1 511 ? -18.455 -64.186 -18.764 1.00 22.24  ? 774  LEU A N   1 
ATOM   3763 C  CA  . LEU A 1 511 ? -18.977 -65.162 -17.768 1.00 23.36  ? 774  LEU A CA  1 
ATOM   3764 C  C   . LEU A 1 511 ? -19.664 -64.412 -16.632 1.00 21.60  ? 774  LEU A C   1 
ATOM   3765 O  O   . LEU A 1 511 ? -20.829 -64.751 -16.287 1.00 19.86  ? 774  LEU A O   1 
ATOM   3766 C  CB  . LEU A 1 511 ? -17.839 -66.019 -17.200 1.00 24.74  ? 774  LEU A CB  1 
ATOM   3767 C  CG  . LEU A 1 511 ? -18.281 -67.310 -16.514 1.00 26.20  ? 774  LEU A CG  1 
ATOM   3768 C  CD1 . LEU A 1 511 ? -17.129 -68.317 -16.490 1.00 27.47  ? 774  LEU A CD1 1 
ATOM   3769 C  CD2 . LEU A 1 511 ? -18.814 -67.071 -15.105 1.00 24.25  ? 774  LEU A CD2 1 
ATOM   3770 N  N   . ALA A 1 512 ? -19.051 -63.374 -16.119 1.00 19.59  ? 775  ALA A N   1 
ATOM   3771 C  CA  . ALA A 1 512 ? -19.618 -62.622 -14.968 1.00 19.77  ? 775  ALA A CA  1 
ATOM   3772 C  C   . ALA A 1 512 ? -20.890 -61.870 -15.422 1.00 19.77  ? 775  ALA A C   1 
ATOM   3773 O  O   . ALA A 1 512 ? -21.895 -61.861 -14.664 1.00 20.34  ? 775  ALA A O   1 
ATOM   3774 C  CB  . ALA A 1 512 ? -18.617 -61.685 -14.369 1.00 18.10  ? 775  ALA A CB  1 
ATOM   3775 N  N   . ALA A 1 513 ? -20.904 -61.361 -16.643 1.00 18.93  ? 776  ALA A N   1 
ATOM   3776 C  CA  . ALA A 1 513 ? -22.079 -60.644 -17.202 1.00 20.54  ? 776  ALA A CA  1 
ATOM   3777 C  C   . ALA A 1 513 ? -23.249 -61.626 -17.290 1.00 20.61  ? 776  ALA A C   1 
ATOM   3778 O  O   . ALA A 1 513 ? -24.380 -61.264 -16.906 1.00 21.63  ? 776  ALA A O   1 
ATOM   3779 C  CB  . ALA A 1 513 ? -21.753 -60.069 -18.556 1.00 19.23  ? 776  ALA A CB  1 
ATOM   3780 N  N   . ASN A 1 514 ? -22.996 -62.797 -17.868 1.00 20.46  ? 777  ASN A N   1 
ATOM   3781 C  CA  . ASN A 1 514 ? -24.040 -63.866 -17.972 1.00 23.42  ? 777  ASN A CA  1 
ATOM   3782 C  C   . ASN A 1 514 ? -24.557 -64.235 -16.581 1.00 23.96  ? 777  ASN A C   1 
ATOM   3783 O  O   . ASN A 1 514 ? -25.793 -64.369 -16.421 1.00 23.48  ? 777  ASN A O   1 
ATOM   3784 C  CB  . ASN A 1 514 ? -23.508 -65.091 -18.700 1.00 23.70  ? 777  ASN A CB  1 
ATOM   3785 C  CG  . ASN A 1 514 ? -23.427 -64.828 -20.195 1.00 26.94  ? 777  ASN A CG  1 
ATOM   3786 O  OD1 . ASN A 1 514 ? -24.272 -64.138 -20.761 1.00 29.94  ? 777  ASN A OD1 1 
ATOM   3787 N  ND2 . ASN A 1 514 ? -22.457 -65.431 -20.848 1.00 31.48  ? 777  ASN A ND2 1 
ATOM   3788 N  N   . ALA A 1 515 ? -23.676 -64.381 -15.598 1.00 21.00  ? 778  ALA A N   1 
ATOM   3789 C  CA  . ALA A 1 515 ? -24.046 -64.719 -14.202 1.00 21.16  ? 778  ALA A CA  1 
ATOM   3790 C  C   . ALA A 1 515 ? -24.938 -63.625 -13.593 1.00 21.87  ? 778  ALA A C   1 
ATOM   3791 O  O   . ALA A 1 515 ? -25.986 -63.956 -13.038 1.00 21.69  ? 778  ALA A O   1 
ATOM   3792 C  CB  . ALA A 1 515 ? -22.826 -64.975 -13.380 1.00 20.78  ? 778  ALA A CB  1 
ATOM   3793 N  N   . ILE A 1 516 ? -24.575 -62.354 -13.733 1.00 19.91  ? 779  ILE A N   1 
ATOM   3794 C  CA  . ILE A 1 516 ? -25.348 -61.222 -13.154 1.00 21.22  ? 779  ILE A CA  1 
ATOM   3795 C  C   . ILE A 1 516 ? -26.717 -61.218 -13.835 1.00 21.57  ? 779  ILE A C   1 
ATOM   3796 O  O   . ILE A 1 516 ? -27.707 -61.103 -13.132 1.00 22.82  ? 779  ILE A O   1 
ATOM   3797 C  CB  . ILE A 1 516 ? -24.607 -59.869 -13.314 1.00 19.46  ? 779  ILE A CB  1 
ATOM   3798 C  CG1 . ILE A 1 516 ? -23.315 -59.874 -12.487 1.00 20.22  ? 779  ILE A CG1 1 
ATOM   3799 C  CG2 . ILE A 1 516 ? -25.535 -58.718 -12.936 1.00 19.66  ? 779  ILE A CG2 1 
ATOM   3800 C  CD1 . ILE A 1 516 ? -22.302 -58.771 -12.889 1.00 22.16  ? 779  ILE A CD1 1 
ATOM   3801 N  N   . CYS A 1 517 ? -26.764 -61.355 -15.166 1.00 21.76  ? 780  CYS A N   1 
ATOM   3802 C  CA  . CYS A 1 517 ? -28.043 -61.305 -15.919 1.00 23.38  ? 780  CYS A CA  1 
ATOM   3803 C  C   . CYS A 1 517 ? -28.915 -62.513 -15.556 1.00 24.60  ? 780  CYS A C   1 
ATOM   3804 O  O   . CYS A 1 517 ? -30.166 -62.390 -15.657 1.00 24.81  ? 780  CYS A O   1 
ATOM   3805 C  CB  . CYS A 1 517 ? -27.829 -61.148 -17.423 1.00 24.15  ? 780  CYS A CB  1 
ATOM   3806 S  SG  . CYS A 1 517 ? -27.187 -59.503 -17.838 1.00 26.46  ? 780  CYS A SG  1 
ATOM   3807 N  N   . SER A 1 518 ? -28.317 -63.599 -15.092 1.00 23.31  ? 781  SER A N   1 
ATOM   3808 C  CA  . SER A 1 518 ? -29.039 -64.817 -14.650 1.00 25.13  ? 781  SER A CA  1 
ATOM   3809 C  C   . SER A 1 518 ? -29.567 -64.589 -13.239 1.00 25.23  ? 781  SER A C   1 
ATOM   3810 O  O   . SER A 1 518 ? -30.596 -65.211 -12.881 1.00 23.26  ? 781  SER A O   1 
ATOM   3811 C  CB  . SER A 1 518 ? -28.172 -66.050 -14.698 1.00 24.53  ? 781  SER A CB  1 
ATOM   3812 O  OG  . SER A 1 518 ? -27.816 -66.326 -16.025 1.00 25.30  ? 781  SER A OG  1 
ATOM   3813 N  N   . ALA A 1 519 ? -28.889 -63.748 -12.461 1.00 22.01  ? 782  ALA A N   1 
ATOM   3814 C  CA  . ALA A 1 519 ? -29.142 -63.575 -11.004 1.00 21.49  ? 782  ALA A CA  1 
ATOM   3815 C  C   . ALA A 1 519 ? -30.204 -62.501 -10.761 1.00 21.72  ? 782  ALA A C   1 
ATOM   3816 O  O   . ALA A 1 519 ? -30.732 -62.466 -9.646  1.00 25.36  ? 782  ALA A O   1 
ATOM   3817 C  CB  . ALA A 1 519 ? -27.884 -63.273 -10.232 1.00 22.78  ? 782  ALA A CB  1 
ATOM   3818 N  N   . VAL A 1 520 ? -30.365 -61.582 -11.691 1.00 21.86  ? 783  VAL A N   1 
ATOM   3819 C  CA  . VAL A 1 520 ? -31.295 -60.440 -11.585 1.00 22.12  ? 783  VAL A CA  1 
ATOM   3820 C  C   . VAL A 1 520 ? -32.556 -60.831 -12.373 1.00 22.82  ? 783  VAL A C   1 
ATOM   3821 O  O   . VAL A 1 520 ? -32.489 -61.335 -13.508 1.00 23.66  ? 783  VAL A O   1 
ATOM   3822 C  CB  . VAL A 1 520 ? -30.629 -59.159 -12.114 1.00 24.58  ? 783  VAL A CB  1 
ATOM   3823 C  CG1 . VAL A 1 520 ? -31.595 -57.979 -12.122 1.00 22.70  ? 783  VAL A CG1 1 
ATOM   3824 C  CG2 . VAL A 1 520 ? -29.372 -58.788 -11.312 1.00 21.86  ? 783  VAL A CG2 1 
ATOM   3825 N  N   . PRO A 1 521 ? -33.776 -60.546 -11.850 1.00 22.57  ? 784  PRO A N   1 
ATOM   3826 C  CA  . PRO A 1 521 ? -34.981 -60.888 -12.599 1.00 24.24  ? 784  PRO A CA  1 
ATOM   3827 C  C   . PRO A 1 521 ? -34.939 -60.382 -14.042 1.00 25.55  ? 784  PRO A C   1 
ATOM   3828 O  O   . PRO A 1 521 ? -34.581 -59.220 -14.279 1.00 24.90  ? 784  PRO A O   1 
ATOM   3829 C  CB  . PRO A 1 521 ? -36.100 -60.239 -11.740 1.00 22.38  ? 784  PRO A CB  1 
ATOM   3830 C  CG  . PRO A 1 521 ? -35.565 -60.377 -10.322 1.00 24.69  ? 784  PRO A CG  1 
ATOM   3831 C  CD  . PRO A 1 521 ? -34.075 -60.041 -10.503 1.00 23.24  ? 784  PRO A CD  1 
ATOM   3832 N  N   A SER A 1 522 ? -35.346 -61.240 -14.980 0.25 27.34  ? 785  SER A N   1 
ATOM   3833 N  N   B SER A 1 522 ? -35.369 -61.248 -14.966 0.25 27.40  ? 785  SER A N   1 
ATOM   3834 C  CA  A SER A 1 522 ? -35.208 -61.045 -16.448 0.25 28.83  ? 785  SER A CA  1 
ATOM   3835 C  CA  B SER A 1 522 ? -35.264 -61.090 -16.442 0.25 29.08  ? 785  SER A CA  1 
ATOM   3836 C  C   A SER A 1 522 ? -35.830 -59.721 -16.900 0.25 28.09  ? 785  SER A C   1 
ATOM   3837 C  C   B SER A 1 522 ? -35.842 -59.749 -16.903 0.25 28.16  ? 785  SER A C   1 
ATOM   3838 O  O   A SER A 1 522 ? -35.219 -59.058 -17.762 0.25 25.68  ? 785  SER A O   1 
ATOM   3839 O  O   B SER A 1 522 ? -35.213 -59.108 -17.765 0.25 25.86  ? 785  SER A O   1 
ATOM   3840 C  CB  A SER A 1 522 ? -35.823 -62.201 -17.193 0.25 32.41  ? 785  SER A CB  1 
ATOM   3841 C  CB  B SER A 1 522 ? -35.951 -62.241 -17.152 0.25 32.62  ? 785  SER A CB  1 
ATOM   3842 O  OG  A SER A 1 522 ? -37.235 -62.182 -17.049 0.25 33.91  ? 785  SER A OG  1 
ATOM   3843 O  OG  B SER A 1 522 ? -35.842 -63.445 -16.405 0.25 34.45  ? 785  SER A OG  1 
ATOM   3844 N  N   . HIS A 1 523 ? -37.000 -59.340 -16.359 1.00 27.01  ? 786  HIS A N   1 
ATOM   3845 C  CA  . HIS A 1 523 ? -37.706 -58.103 -16.797 1.00 25.51  ? 786  HIS A CA  1 
ATOM   3846 C  C   . HIS A 1 523 ? -37.310 -56.839 -16.043 1.00 27.17  ? 786  HIS A C   1 
ATOM   3847 O  O   . HIS A 1 523 ? -37.758 -55.759 -16.473 1.00 28.82  ? 786  HIS A O   1 
ATOM   3848 C  CB  . HIS A 1 523 ? -39.221 -58.344 -16.796 1.00 28.90  ? 786  HIS A CB  1 
ATOM   3849 C  CG  . HIS A 1 523 ? -39.615 -59.464 -17.706 1.00 27.93  ? 786  HIS A CG  1 
ATOM   3850 N  ND1 . HIS A 1 523 ? -39.703 -59.293 -19.069 1.00 30.63  ? 786  HIS A ND1 1 
ATOM   3851 C  CD2 . HIS A 1 523 ? -39.855 -60.773 -17.473 1.00 35.70  ? 786  HIS A CD2 1 
ATOM   3852 C  CE1 . HIS A 1 523 ? -40.022 -60.446 -19.639 1.00 31.79  ? 786  HIS A CE1 1 
ATOM   3853 N  NE2 . HIS A 1 523 ? -40.154 -61.381 -18.686 1.00 33.00  ? 786  HIS A NE2 1 
ATOM   3854 N  N   . TRP A 1 524 ? -36.468 -56.890 -15.005 1.00 26.10  ? 787  TRP A N   1 
ATOM   3855 C  CA  . TRP A 1 524 ? -36.089 -55.651 -14.278 1.00 26.67  ? 787  TRP A CA  1 
ATOM   3856 C  C   . TRP A 1 524 ? -35.196 -54.777 -15.166 1.00 26.31  ? 787  TRP A C   1 
ATOM   3857 O  O   . TRP A 1 524 ? -34.340 -55.306 -15.859 1.00 30.33  ? 787  TRP A O   1 
ATOM   3858 C  CB  . TRP A 1 524 ? -35.486 -55.982 -12.906 1.00 26.07  ? 787  TRP A CB  1 
ATOM   3859 C  CG  . TRP A 1 524 ? -36.491 -56.466 -11.899 1.00 28.29  ? 787  TRP A CG  1 
ATOM   3860 C  CD1 . TRP A 1 524 ? -37.814 -56.808 -12.085 1.00 27.77  ? 787  TRP A CD1 1 
ATOM   3861 C  CD2 . TRP A 1 524 ? -36.204 -56.745 -10.513 1.00 26.86  ? 787  TRP A CD2 1 
ATOM   3862 N  NE1 . TRP A 1 524 ? -38.363 -57.250 -10.904 1.00 27.24  ? 787  TRP A NE1 1 
ATOM   3863 C  CE2 . TRP A 1 524 ? -37.408 -57.191 -9.915  1.00 26.99  ? 787  TRP A CE2 1 
ATOM   3864 C  CE3 . TRP A 1 524 ? -35.047 -56.653 -9.737  1.00 27.88  ? 787  TRP A CE3 1 
ATOM   3865 C  CZ2 . TRP A 1 524 ? -37.472 -57.560 -8.571  1.00 28.35  ? 787  TRP A CZ2 1 
ATOM   3866 C  CZ3 . TRP A 1 524 ? -35.127 -57.024 -8.404  1.00 28.63  ? 787  TRP A CZ3 1 
ATOM   3867 C  CH2 . TRP A 1 524 ? -36.324 -57.432 -7.828  1.00 26.62  ? 787  TRP A CH2 1 
ATOM   3868 N  N   . VAL A 1 525 ? -35.423 -53.477 -15.150 1.00 25.68  ? 788  VAL A N   1 
ATOM   3869 C  CA  . VAL A 1 525 ? -34.851 -52.517 -16.126 1.00 27.69  ? 788  VAL A CA  1 
ATOM   3870 C  C   . VAL A 1 525 ? -33.517 -52.027 -15.583 1.00 26.27  ? 788  VAL A C   1 
ATOM   3871 O  O   . VAL A 1 525 ? -33.426 -51.536 -14.461 1.00 28.81  ? 788  VAL A O   1 
ATOM   3872 C  CB  . VAL A 1 525 ? -35.821 -51.338 -16.365 1.00 30.97  ? 788  VAL A CB  1 
ATOM   3873 C  CG1 . VAL A 1 525 ? -35.228 -50.269 -17.290 1.00 32.30  ? 788  VAL A CG1 1 
ATOM   3874 C  CG2 . VAL A 1 525 ? -37.188 -51.818 -16.874 1.00 33.85  ? 788  VAL A CG2 1 
ATOM   3875 N  N   . PRO A 1 526 ? -32.429 -52.112 -16.353 1.00 29.71  ? 789  PRO A N   1 
ATOM   3876 C  CA  . PRO A 1 526 ? -31.150 -51.580 -15.888 1.00 28.42  ? 789  PRO A CA  1 
ATOM   3877 C  C   . PRO A 1 526 ? -31.236 -50.082 -15.570 1.00 32.70  ? 789  PRO A C   1 
ATOM   3878 O  O   . PRO A 1 526 ? -31.931 -49.389 -16.320 1.00 30.76  ? 789  PRO A O   1 
ATOM   3879 C  CB  . PRO A 1 526 ? -30.221 -51.750 -17.088 1.00 28.80  ? 789  PRO A CB  1 
ATOM   3880 C  CG  . PRO A 1 526 ? -30.870 -52.738 -17.983 1.00 28.75  ? 789  PRO A CG  1 
ATOM   3881 C  CD  . PRO A 1 526 ? -32.356 -52.670 -17.716 1.00 27.66  ? 789  PRO A CD  1 
ATOM   3882 N  N   . THR A 1 527 ? -30.578 -49.631 -14.493 1.00 36.15  ? 790  THR A N   1 
ATOM   3883 C  CA  . THR A 1 527 ? -30.588 -48.215 -14.026 1.00 42.72  ? 790  THR A CA  1 
ATOM   3884 C  C   . THR A 1 527 ? -29.185 -47.651 -13.857 1.00 42.34  ? 790  THR A C   1 
ATOM   3885 O  O   . THR A 1 527 ? -28.219 -48.443 -13.754 1.00 39.57  ? 790  THR A O   1 
ATOM   3886 C  CB  . THR A 1 527 ? -31.261 -48.007 -12.664 1.00 53.08  ? 790  THR A CB  1 
ATOM   3887 O  OG1 . THR A 1 527 ? -30.580 -48.779 -11.659 1.00 61.45  ? 790  THR A OG1 1 
ATOM   3888 C  CG2 . THR A 1 527 ? -32.732 -48.327 -12.731 1.00 60.49  ? 790  THR A CG2 1 
ATOM   3889 N  N   . SER A 1 528 ? -29.154 -46.326 -13.753 1.00 45.73  ? 791  SER A N   1 
ATOM   3890 C  CA  . SER A 1 528 ? -28.004 -45.380 -13.783 1.00 57.43  ? 791  SER A CA  1 
ATOM   3891 C  C   . SER A 1 528 ? -26.857 -45.883 -14.651 1.00 56.54  ? 791  SER A C   1 
ATOM   3892 O  O   . SER A 1 528 ? -25.787 -45.268 -14.520 1.00 74.79  ? 791  SER A O   1 
ATOM   3893 C  CB  . SER A 1 528 ? -27.559 -45.055 -12.398 1.00 58.43  ? 791  SER A CB  1 
ATOM   3894 O  OG  . SER A 1 528 ? -28.363 -44.008 -11.880 1.00 61.38  ? 791  SER A OG  1 
ATOM   3895 N  N   . ALA A 1 536 ? -20.359 -40.507 -26.285 1.00 102.70 ? 799  ALA A N   1 
ATOM   3896 C  CA  . ALA A 1 536 ? -20.699 -41.794 -25.641 1.00 100.12 ? 799  ALA A CA  1 
ATOM   3897 C  C   . ALA A 1 536 ? -22.113 -42.215 -26.044 1.00 101.20 ? 799  ALA A C   1 
ATOM   3898 O  O   . ALA A 1 536 ? -22.945 -41.324 -26.293 1.00 109.85 ? 799  ALA A O   1 
ATOM   3899 C  CB  . ALA A 1 536 ? -20.572 -41.656 -24.147 1.00 96.46  ? 799  ALA A CB  1 
ATOM   3900 N  N   . THR A 1 537 ? -22.370 -43.519 -26.095 1.00 92.72  ? 800  THR A N   1 
ATOM   3901 C  CA  . THR A 1 537 ? -23.710 -44.037 -26.450 1.00 86.43  ? 800  THR A CA  1 
ATOM   3902 C  C   . THR A 1 537 ? -23.989 -45.237 -25.549 1.00 82.89  ? 800  THR A C   1 
ATOM   3903 O  O   . THR A 1 537 ? -23.141 -46.140 -25.537 1.00 98.39  ? 800  THR A O   1 
ATOM   3904 C  CB  . THR A 1 537 ? -23.749 -44.397 -27.934 1.00 85.18  ? 800  THR A CB  1 
ATOM   3905 O  OG1 . THR A 1 537 ? -22.706 -45.338 -28.182 1.00 91.19  ? 800  THR A OG1 1 
ATOM   3906 C  CG2 . THR A 1 537 ? -23.576 -43.191 -28.829 1.00 80.20  ? 800  THR A CG2 1 
ATOM   3907 N  N   . HIS A 1 538 ? -25.125 -45.252 -24.845 1.00 74.34  ? 801  HIS A N   1 
ATOM   3908 C  CA  . HIS A 1 538 ? -25.376 -46.337 -23.856 1.00 56.39  ? 801  HIS A CA  1 
ATOM   3909 C  C   . HIS A 1 538 ? -26.412 -47.335 -24.384 1.00 38.89  ? 801  HIS A C   1 
ATOM   3910 O  O   . HIS A 1 538 ? -27.506 -47.415 -23.822 1.00 33.73  ? 801  HIS A O   1 
ATOM   3911 C  CB  . HIS A 1 538 ? -25.681 -45.708 -22.502 1.00 60.76  ? 801  HIS A CB  1 
ATOM   3912 C  CG  . HIS A 1 538 ? -24.508 -44.979 -21.943 1.00 68.91  ? 801  HIS A CG  1 
ATOM   3913 N  ND1 . HIS A 1 538 ? -24.347 -44.757 -20.593 1.00 79.07  ? 801  HIS A ND1 1 
ATOM   3914 C  CD2 . HIS A 1 538 ? -23.430 -44.436 -22.548 1.00 72.29  ? 801  HIS A CD2 1 
ATOM   3915 C  CE1 . HIS A 1 538 ? -23.226 -44.097 -20.389 1.00 78.06  ? 801  HIS A CE1 1 
ATOM   3916 N  NE2 . HIS A 1 538 ? -22.644 -43.888 -21.573 1.00 77.12  ? 801  HIS A NE2 1 
ATOM   3917 N  N   . GLU A 1 539 ? -26.021 -48.114 -25.386 1.00 34.44  ? 802  GLU A N   1 
ATOM   3918 C  CA  . GLU A 1 539 ? -26.942 -49.094 -26.011 1.00 35.46  ? 802  GLU A CA  1 
ATOM   3919 C  C   . GLU A 1 539 ? -27.243 -50.261 -25.063 1.00 34.79  ? 802  GLU A C   1 
ATOM   3920 O  O   . GLU A 1 539 ? -28.159 -51.026 -25.376 1.00 34.38  ? 802  GLU A O   1 
ATOM   3921 C  CB  . GLU A 1 539 ? -26.349 -49.571 -27.332 1.00 44.47  ? 802  GLU A CB  1 
ATOM   3922 C  CG  . GLU A 1 539 ? -26.343 -48.520 -28.421 1.00 47.35  ? 802  GLU A CG  1 
ATOM   3923 C  CD  . GLU A 1 539 ? -25.082 -47.681 -28.456 1.00 55.42  ? 802  GLU A CD  1 
ATOM   3924 O  OE1 . GLU A 1 539 ? -24.855 -47.011 -29.478 1.00 67.93  ? 802  GLU A OE1 1 
ATOM   3925 O  OE2 . GLU A 1 539 ? -24.330 -47.706 -27.464 1.00 61.86  ? 802  GLU A OE2 1 
ATOM   3926 N  N   . TRP A 1 540 ? -26.498 -50.380 -23.959 1.00 28.44  ? 803  TRP A N   1 
ATOM   3927 C  CA  . TRP A 1 540 ? -26.718 -51.469 -22.972 1.00 29.48  ? 803  TRP A CA  1 
ATOM   3928 C  C   . TRP A 1 540 ? -27.870 -51.116 -22.022 1.00 30.79  ? 803  TRP A C   1 
ATOM   3929 O  O   . TRP A 1 540 ? -28.259 -51.975 -21.236 1.00 27.00  ? 803  TRP A O   1 
ATOM   3930 C  CB  . TRP A 1 540 ? -25.422 -51.773 -22.206 1.00 26.05  ? 803  TRP A CB  1 
ATOM   3931 C  CG  . TRP A 1 540 ? -24.823 -50.610 -21.481 1.00 25.51  ? 803  TRP A CG  1 
ATOM   3932 C  CD1 . TRP A 1 540 ? -25.128 -50.173 -20.226 1.00 24.90  ? 803  TRP A CD1 1 
ATOM   3933 C  CD2 . TRP A 1 540 ? -23.785 -49.744 -21.966 1.00 24.40  ? 803  TRP A CD2 1 
ATOM   3934 N  NE1 . TRP A 1 540 ? -24.362 -49.087 -19.903 1.00 28.46  ? 803  TRP A NE1 1 
ATOM   3935 C  CE2 . TRP A 1 540 ? -23.529 -48.801 -20.951 1.00 27.80  ? 803  TRP A CE2 1 
ATOM   3936 C  CE3 . TRP A 1 540 ? -23.057 -49.670 -23.157 1.00 29.77  ? 803  TRP A CE3 1 
ATOM   3937 C  CZ2 . TRP A 1 540 ? -22.572 -47.799 -21.095 1.00 32.45  ? 803  TRP A CZ2 1 
ATOM   3938 C  CZ3 . TRP A 1 540 ? -22.113 -48.680 -23.298 1.00 34.44  ? 803  TRP A CZ3 1 
ATOM   3939 C  CH2 . TRP A 1 540 ? -21.875 -47.759 -22.279 1.00 30.79  ? 803  TRP A CH2 1 
ATOM   3940 N  N   . MET A 1 541 ? -28.367 -49.877 -22.086 1.00 32.69  ? 804  MET A N   1 
ATOM   3941 C  CA  . MET A 1 541 ? -29.432 -49.452 -21.140 1.00 32.65  ? 804  MET A CA  1 
ATOM   3942 C  C   . MET A 1 541 ? -30.786 -49.802 -21.793 1.00 37.43  ? 804  MET A C   1 
ATOM   3943 O  O   . MET A 1 541 ? -31.374 -48.920 -22.393 1.00 32.33  ? 804  MET A O   1 
ATOM   3944 C  CB  . MET A 1 541 ? -29.349 -47.956 -20.808 1.00 35.52  ? 804  MET A CB  1 
ATOM   3945 C  CG  . MET A 1 541 ? -28.089 -47.553 -20.063 1.00 37.88  ? 804  MET A CG  1 
ATOM   3946 S  SD  . MET A 1 541 ? -27.854 -48.521 -18.532 1.00 36.88  ? 804  MET A SD  1 
ATOM   3947 C  CE  . MET A 1 541 ? -29.093 -47.774 -17.478 1.00 41.36  ? 804  MET A CE  1 
ATOM   3948 N  N   . THR A 1 542 ? -31.228 -51.059 -21.699 1.00 33.77  ? 805  THR A N   1 
ATOM   3949 C  CA  . THR A 1 542 ? -32.387 -51.616 -22.464 1.00 34.12  ? 805  THR A CA  1 
ATOM   3950 C  C   . THR A 1 542 ? -32.775 -52.956 -21.864 1.00 30.53  ? 805  THR A C   1 
ATOM   3951 O  O   . THR A 1 542 ? -31.903 -53.592 -21.241 1.00 26.76  ? 805  THR A O   1 
ATOM   3952 C  CB  . THR A 1 542 ? -32.048 -51.766 -23.955 1.00 40.56  ? 805  THR A CB  1 
ATOM   3953 O  OG1 . THR A 1 542 ? -33.097 -52.402 -24.690 1.00 41.89  ? 805  THR A OG1 1 
ATOM   3954 C  CG2 . THR A 1 542 ? -30.796 -52.586 -24.174 1.00 44.13  ? 805  THR A CG2 1 
ATOM   3955 N  N   . THR A 1 543 ? -34.022 -53.411 -22.066 1.00 27.94  ? 806  THR A N   1 
ATOM   3956 C  CA  . THR A 1 543 ? -34.462 -54.790 -21.729 1.00 30.58  ? 806  THR A CA  1 
ATOM   3957 C  C   . THR A 1 543 ? -34.508 -55.671 -22.982 1.00 29.10  ? 806  THR A C   1 
ATOM   3958 O  O   . THR A 1 543 ? -34.846 -56.838 -22.841 1.00 31.11  ? 806  THR A O   1 
ATOM   3959 C  CB  . THR A 1 543 ? -35.825 -54.747 -21.015 1.00 39.24  ? 806  THR A CB  1 
ATOM   3960 O  OG1 . THR A 1 543 ? -36.641 -53.893 -21.815 1.00 34.26  ? 806  THR A OG1 1 
ATOM   3961 C  CG2 . THR A 1 543 ? -35.697 -54.150 -19.627 1.00 42.51  ? 806  THR A CG2 1 
ATOM   3962 N  N   . GLU A 1 544 ? -34.109 -55.157 -24.143 1.00 29.39  ? 807  GLU A N   1 
ATOM   3963 C  CA  . GLU A 1 544 ? -33.967 -55.970 -25.376 1.00 32.54  ? 807  GLU A CA  1 
ATOM   3964 C  C   . GLU A 1 544 ? -32.889 -57.044 -25.173 1.00 34.39  ? 807  GLU A C   1 
ATOM   3965 O  O   . GLU A 1 544 ? -31.978 -56.861 -24.335 1.00 32.16  ? 807  GLU A O   1 
ATOM   3966 C  CB  . GLU A 1 544 ? -33.653 -55.034 -26.533 1.00 36.70  ? 807  GLU A CB  1 
ATOM   3967 C  CG  . GLU A 1 544 ? -33.543 -55.734 -27.843 1.00 43.18  ? 807  GLU A CG  1 
ATOM   3968 C  CD  . GLU A 1 544 ? -33.728 -54.766 -28.998 1.00 53.66  ? 807  GLU A CD  1 
ATOM   3969 O  OE1 . GLU A 1 544 ? -34.363 -55.178 -30.013 1.00 54.99  ? 807  GLU A OE1 1 
ATOM   3970 O  OE2 . GLU A 1 544 ? -33.267 -53.594 -28.863 1.00 46.77  ? 807  GLU A OE2 1 
ATOM   3971 N  N   . ASP A 1 545 ? -33.065 -58.182 -25.819 1.00 31.89  ? 808  ASP A N   1 
ATOM   3972 C  CA  . ASP A 1 545 ? -32.114 -59.316 -25.825 1.00 34.55  ? 808  ASP A CA  1 
ATOM   3973 C  C   . ASP A 1 545 ? -30.702 -58.791 -26.197 1.00 29.00  ? 808  ASP A C   1 
ATOM   3974 O  O   . ASP A 1 545 ? -30.579 -58.089 -27.227 1.00 27.49  ? 808  ASP A O   1 
ATOM   3975 C  CB  . ASP A 1 545 ? -32.634 -60.352 -26.818 1.00 39.71  ? 808  ASP A CB  1 
ATOM   3976 C  CG  . ASP A 1 545 ? -31.739 -61.549 -27.046 1.00 47.61  ? 808  ASP A CG  1 
ATOM   3977 O  OD1 . ASP A 1 545 ? -30.719 -61.381 -27.708 1.00 52.56  ? 808  ASP A OD1 1 
ATOM   3978 O  OD2 . ASP A 1 545 ? -32.116 -62.646 -26.627 1.00 65.57  ? 808  ASP A OD2 1 
ATOM   3979 N  N   . MET A 1 546 ? -29.660 -59.126 -25.431 1.00 28.11  ? 809  MET A N   1 
ATOM   3980 C  CA  . MET A 1 546 ? -28.286 -58.539 -25.669 1.00 27.33  ? 809  MET A CA  1 
ATOM   3981 C  C   . MET A 1 546 ? -27.692 -59.085 -26.979 1.00 26.26  ? 809  MET A C   1 
ATOM   3982 O  O   . MET A 1 546 ? -26.935 -58.337 -27.622 1.00 25.26  ? 809  MET A O   1 
ATOM   3983 C  CB  . MET A 1 546 ? -27.347 -58.764 -24.476 1.00 30.07  ? 809  MET A CB  1 
ATOM   3984 C  CG  . MET A 1 546 ? -27.672 -57.819 -23.287 1.00 30.30  ? 809  MET A CG  1 
ATOM   3985 S  SD  . MET A 1 546 ? -27.644 -56.028 -23.711 1.00 36.69  ? 809  MET A SD  1 
ATOM   3986 C  CE  . MET A 1 546 ? -29.347 -55.663 -24.075 1.00 50.74  ? 809  MET A CE  1 
ATOM   3987 N  N   . LEU A 1 547 ? -28.058 -60.290 -27.437 1.00 23.06  ? 810  LEU A N   1 
ATOM   3988 C  CA  . LEU A 1 547 ? -27.570 -60.748 -28.765 1.00 26.49  ? 810  LEU A CA  1 
ATOM   3989 C  C   . LEU A 1 547 ? -28.135 -59.840 -29.855 1.00 27.68  ? 810  LEU A C   1 
ATOM   3990 O  O   . LEU A 1 547 ? -27.366 -59.527 -30.792 1.00 27.38  ? 810  LEU A O   1 
ATOM   3991 C  CB  . LEU A 1 547 ? -27.866 -62.216 -29.052 1.00 30.32  ? 810  LEU A CB  1 
ATOM   3992 C  CG  . LEU A 1 547 ? -27.195 -62.774 -30.323 1.00 29.83  ? 810  LEU A CG  1 
ATOM   3993 C  CD1 . LEU A 1 547 ? -25.654 -62.724 -30.258 1.00 29.66  ? 810  LEU A CD1 1 
ATOM   3994 C  CD2 . LEU A 1 547 ? -27.625 -64.198 -30.556 1.00 32.10  ? 810  LEU A CD2 1 
ATOM   3995 N  N   . THR A 1 548 ? -29.426 -59.462 -29.797 1.00 27.40  ? 811  THR A N   1 
ATOM   3996 C  CA  . THR A 1 548 ? -30.041 -58.560 -30.792 1.00 27.84  ? 811  THR A CA  1 
ATOM   3997 C  C   . THR A 1 548 ? -29.336 -57.194 -30.763 1.00 27.55  ? 811  THR A C   1 
ATOM   3998 O  O   . THR A 1 548 ? -29.039 -56.642 -31.806 1.00 25.08  ? 811  THR A O   1 
ATOM   3999 C  CB  . THR A 1 548 ? -31.559 -58.438 -30.569 1.00 33.07  ? 811  THR A CB  1 
ATOM   4000 O  OG1 . THR A 1 548 ? -32.088 -59.765 -30.643 1.00 32.46  ? 811  THR A OG1 1 
ATOM   4001 C  CG2 . THR A 1 548 ? -32.226 -57.560 -31.600 1.00 33.46  ? 811  THR A CG2 1 
ATOM   4002 N  N   . VAL A 1 549 ? -29.055 -56.667 -29.592 1.00 23.73  ? 812  VAL A N   1 
ATOM   4003 C  CA  . VAL A 1 549 ? -28.330 -55.384 -29.461 1.00 27.52  ? 812  VAL A CA  1 
ATOM   4004 C  C   . VAL A 1 549 ? -26.895 -55.531 -30.001 1.00 24.61  ? 812  VAL A C   1 
ATOM   4005 O  O   . VAL A 1 549 ? -26.416 -54.585 -30.691 1.00 25.53  ? 812  VAL A O   1 
ATOM   4006 C  CB  . VAL A 1 549 ? -28.342 -54.864 -28.014 1.00 27.63  ? 812  VAL A CB  1 
ATOM   4007 C  CG1 . VAL A 1 549 ? -27.587 -53.547 -27.960 1.00 28.89  ? 812  VAL A CG1 1 
ATOM   4008 C  CG2 . VAL A 1 549 ? -29.771 -54.673 -27.513 1.00 32.73  ? 812  VAL A CG2 1 
ATOM   4009 N  N   . TRP A 1 550 ? -26.238 -56.657 -29.735 1.00 26.84  ? 813  TRP A N   1 
ATOM   4010 C  CA  . TRP A 1 550 ? -24.851 -56.872 -30.203 1.00 23.97  ? 813  TRP A CA  1 
ATOM   4011 C  C   . TRP A 1 550 ? -24.878 -56.806 -31.746 1.00 28.93  ? 813  TRP A C   1 
ATOM   4012 O  O   . TRP A 1 550 ? -24.035 -56.103 -32.373 1.00 24.57  ? 813  TRP A O   1 
ATOM   4013 C  CB  . TRP A 1 550 ? -24.282 -58.178 -29.646 1.00 23.91  ? 813  TRP A CB  1 
ATOM   4014 C  CG  . TRP A 1 550 ? -22.821 -58.336 -29.926 1.00 23.33  ? 813  TRP A CG  1 
ATOM   4015 C  CD1 . TRP A 1 550 ? -21.801 -58.134 -29.037 1.00 24.92  ? 813  TRP A CD1 1 
ATOM   4016 C  CD2 . TRP A 1 550 ? -22.203 -58.738 -31.158 1.00 23.51  ? 813  TRP A CD2 1 
ATOM   4017 N  NE1 . TRP A 1 550 ? -20.580 -58.352 -29.625 1.00 25.61  ? 813  TRP A NE1 1 
ATOM   4018 C  CE2 . TRP A 1 550 ? -20.797 -58.703 -30.945 1.00 24.62  ? 813  TRP A CE2 1 
ATOM   4019 C  CE3 . TRP A 1 550 ? -22.676 -59.141 -32.412 1.00 25.98  ? 813  TRP A CE3 1 
ATOM   4020 C  CZ2 . TRP A 1 550 ? -19.886 -59.042 -31.940 1.00 25.46  ? 813  TRP A CZ2 1 
ATOM   4021 C  CZ3 . TRP A 1 550 ? -21.776 -59.486 -33.394 1.00 24.07  ? 813  TRP A CZ3 1 
ATOM   4022 C  CH2 . TRP A 1 550 ? -20.395 -59.423 -33.163 1.00 25.59  ? 813  TRP A CH2 1 
ATOM   4023 N  N   . ASN A 1 551 ? -25.814 -57.514 -32.373 1.00 26.08  ? 814  ASN A N   1 
ATOM   4024 C  CA  . ASN A 1 551 ? -25.934 -57.530 -33.853 1.00 26.25  ? 814  ASN A CA  1 
ATOM   4025 C  C   . ASN A 1 551 ? -26.173 -56.116 -34.382 1.00 24.50  ? 814  ASN A C   1 
ATOM   4026 O  O   . ASN A 1 551 ? -25.582 -55.808 -35.414 1.00 28.25  ? 814  ASN A O   1 
ATOM   4027 C  CB  . ASN A 1 551 ? -27.022 -58.476 -34.381 1.00 29.28  ? 814  ASN A CB  1 
ATOM   4028 C  CG  . ASN A 1 551 ? -26.492 -59.878 -34.553 1.00 31.87  ? 814  ASN A CG  1 
ATOM   4029 O  OD1 . ASN A 1 551 ? -25.570 -60.112 -35.336 1.00 40.44  ? 814  ASN A OD1 1 
ATOM   4030 N  ND2 . ASN A 1 551 ? -27.057 -60.839 -33.833 1.00 37.43  ? 814  ASN A ND2 1 
ATOM   4031 N  N   . ARG A 1 552 ? -27.025 -55.316 -33.746 1.00 26.35  ? 815  ARG A N   1 
ATOM   4032 C  CA  . ARG A 1 552 ? -27.355 -53.964 -34.241 1.00 28.95  ? 815  ARG A CA  1 
ATOM   4033 C  C   . ARG A 1 552 ? -26.084 -53.077 -34.198 1.00 30.63  ? 815  ARG A C   1 
ATOM   4034 O  O   . ARG A 1 552 ? -25.781 -52.337 -35.200 1.00 32.39  ? 815  ARG A O   1 
ATOM   4035 C  CB  . ARG A 1 552 ? -28.482 -53.350 -33.420 1.00 29.24  ? 815  ARG A CB  1 
ATOM   4036 C  CG  . ARG A 1 552 ? -28.926 -51.983 -33.932 1.00 35.41  ? 815  ARG A CG  1 
ATOM   4037 C  CD  . ARG A 1 552 ? -30.021 -51.382 -33.039 1.00 38.92  ? 815  ARG A CD  1 
ATOM   4038 N  NE  . ARG A 1 552 ? -31.126 -52.324 -33.058 1.00 48.96  ? 815  ARG A NE  1 
ATOM   4039 C  CZ  . ARG A 1 552 ? -31.719 -52.893 -31.996 1.00 49.73  ? 815  ARG A CZ  1 
ATOM   4040 N  NH1 . ARG A 1 552 ? -31.357 -52.604 -30.753 1.00 44.48  ? 815  ARG A NH1 1 
ATOM   4041 N  NH2 . ARG A 1 552 ? -32.710 -53.739 -32.219 1.00 52.74  ? 815  ARG A NH2 1 
ATOM   4042 N  N   . VAL A 1 553 ? -25.338 -53.162 -33.102 1.00 26.13  ? 816  VAL A N   1 
ATOM   4043 C  CA  . VAL A 1 553 ? -24.178 -52.258 -32.829 1.00 26.26  ? 816  VAL A CA  1 
ATOM   4044 C  C   . VAL A 1 553 ? -22.948 -52.694 -33.633 1.00 26.07  ? 816  VAL A C   1 
ATOM   4045 O  O   . VAL A 1 553 ? -22.279 -51.818 -34.203 1.00 29.99  ? 816  VAL A O   1 
ATOM   4046 C  CB  . VAL A 1 553 ? -23.923 -52.227 -31.307 1.00 28.21  ? 816  VAL A CB  1 
ATOM   4047 C  CG1 . VAL A 1 553 ? -22.590 -51.603 -30.984 1.00 29.86  ? 816  VAL A CG1 1 
ATOM   4048 C  CG2 . VAL A 1 553 ? -25.056 -51.500 -30.604 1.00 29.18  ? 816  VAL A CG2 1 
ATOM   4049 N  N   . TRP A 1 554 ? -22.604 -53.983 -33.667 1.00 23.85  ? 817  TRP A N   1 
ATOM   4050 C  CA  . TRP A 1 554 ? -21.317 -54.458 -34.216 1.00 22.17  ? 817  TRP A CA  1 
ATOM   4051 C  C   . TRP A 1 554 ? -21.444 -54.816 -35.697 1.00 26.64  ? 817  TRP A C   1 
ATOM   4052 O  O   . TRP A 1 554 ? -20.404 -54.850 -36.358 1.00 25.77  ? 817  TRP A O   1 
ATOM   4053 C  CB  . TRP A 1 554 ? -20.764 -55.610 -33.371 1.00 24.96  ? 817  TRP A CB  1 
ATOM   4054 C  CG  . TRP A 1 554 ? -20.246 -55.153 -32.033 1.00 25.48  ? 817  TRP A CG  1 
ATOM   4055 C  CD1 . TRP A 1 554 ? -20.802 -55.319 -30.807 1.00 23.43  ? 817  TRP A CD1 1 
ATOM   4056 C  CD2 . TRP A 1 554 ? -19.007 -54.437 -31.809 1.00 22.12  ? 817  TRP A CD2 1 
ATOM   4057 N  NE1 . TRP A 1 554 ? -20.043 -54.706 -29.843 1.00 24.67  ? 817  TRP A NE1 1 
ATOM   4058 C  CE2 . TRP A 1 554 ? -18.923 -54.169 -30.424 1.00 21.98  ? 817  TRP A CE2 1 
ATOM   4059 C  CE3 . TRP A 1 554 ? -18.008 -53.981 -32.647 1.00 22.69  ? 817  TRP A CE3 1 
ATOM   4060 C  CZ2 . TRP A 1 554 ? -17.843 -53.498 -29.860 1.00 24.82  ? 817  TRP A CZ2 1 
ATOM   4061 C  CZ3 . TRP A 1 554 ? -16.934 -53.296 -32.091 1.00 22.82  ? 817  TRP A CZ3 1 
ATOM   4062 C  CH2 . TRP A 1 554 ? -16.857 -53.062 -30.723 1.00 20.91  ? 817  TRP A CH2 1 
ATOM   4063 N  N   . ILE A 1 555 ? -22.673 -55.081 -36.194 1.00 27.36  ? 818  ILE A N   1 
ATOM   4064 C  CA  . ILE A 1 555 ? -22.871 -55.581 -37.582 1.00 28.14  ? 818  ILE A CA  1 
ATOM   4065 C  C   . ILE A 1 555 ? -23.731 -54.559 -38.314 1.00 30.44  ? 818  ILE A C   1 
ATOM   4066 O  O   . ILE A 1 555 ? -23.186 -53.859 -39.161 1.00 30.49  ? 818  ILE A O   1 
ATOM   4067 C  CB  . ILE A 1 555 ? -23.510 -56.983 -37.671 1.00 30.28  ? 818  ILE A CB  1 
ATOM   4068 C  CG1 . ILE A 1 555 ? -22.793 -58.060 -36.855 1.00 29.42  ? 818  ILE A CG1 1 
ATOM   4069 C  CG2 . ILE A 1 555 ? -23.600 -57.377 -39.143 1.00 29.76  ? 818  ILE A CG2 1 
ATOM   4070 C  CD1 . ILE A 1 555 ? -21.359 -58.188 -37.200 1.00 30.14  ? 818  ILE A CD1 1 
ATOM   4071 N  N   . GLN A 1 556 ? -25.031 -54.469 -37.983 1.00 34.08  ? 819  GLN A N   1 
ATOM   4072 C  CA  . GLN A 1 556 ? -26.022 -53.696 -38.790 1.00 33.25  ? 819  GLN A CA  1 
ATOM   4073 C  C   . GLN A 1 556 ? -25.554 -52.242 -38.937 1.00 32.53  ? 819  GLN A C   1 
ATOM   4074 O  O   . GLN A 1 556 ? -25.456 -51.783 -40.075 1.00 31.71  ? 819  GLN A O   1 
ATOM   4075 C  CB  . GLN A 1 556 ? -27.411 -53.791 -38.146 1.00 34.29  ? 819  GLN A CB  1 
ATOM   4076 C  CG  . GLN A 1 556 ? -28.512 -53.025 -38.893 1.00 44.90  ? 819  GLN A CG  1 
ATOM   4077 C  CD  . GLN A 1 556 ? -29.765 -52.808 -38.063 1.00 50.47  ? 819  GLN A CD  1 
ATOM   4078 O  OE1 . GLN A 1 556 ? -30.325 -51.703 -38.011 1.00 58.24  ? 819  GLN A OE1 1 
ATOM   4079 N  NE2 . GLN A 1 556 ? -30.205 -53.846 -37.362 1.00 49.59  ? 819  GLN A NE2 1 
ATOM   4080 N  N   . GLU A 1 557 ? -25.303 -51.538 -37.832 1.00 28.22  ? 820  GLU A N   1 
ATOM   4081 C  CA  . GLU A 1 557 ? -25.067 -50.069 -37.806 1.00 31.39  ? 820  GLU A CA  1 
ATOM   4082 C  C   . GLU A 1 557 ? -23.561 -49.742 -37.896 1.00 33.27  ? 820  GLU A C   1 
ATOM   4083 O  O   . GLU A 1 557 ? -23.186 -48.532 -37.835 1.00 33.97  ? 820  GLU A O   1 
ATOM   4084 C  CB  . GLU A 1 557 ? -25.724 -49.487 -36.558 1.00 32.67  ? 820  GLU A CB  1 
ATOM   4085 C  CG  . GLU A 1 557 ? -27.235 -49.726 -36.531 1.00 42.04  ? 820  GLU A CG  1 
ATOM   4086 C  CD  . GLU A 1 557 ? -28.016 -48.940 -35.470 1.00 50.94  ? 820  GLU A CD  1 
ATOM   4087 O  OE1 . GLU A 1 557 ? -27.393 -48.553 -34.444 1.00 57.65  ? 820  GLU A OE1 1 
ATOM   4088 O  OE2 . GLU A 1 557 ? -29.272 -48.737 -35.646 1.00 60.58  ? 820  GLU A OE2 1 
ATOM   4089 N  N   . ASN A 1 558 ? -22.714 -50.750 -38.063 1.00 28.55  ? 821  ASN A N   1 
ATOM   4090 C  CA  . ASN A 1 558 ? -21.226 -50.567 -38.053 1.00 29.50  ? 821  ASN A CA  1 
ATOM   4091 C  C   . ASN A 1 558 ? -20.758 -50.186 -39.459 1.00 27.91  ? 821  ASN A C   1 
ATOM   4092 O  O   . ASN A 1 558 ? -20.648 -51.039 -40.327 1.00 27.58  ? 821  ASN A O   1 
ATOM   4093 C  CB  . ASN A 1 558 ? -20.574 -51.836 -37.505 1.00 27.28  ? 821  ASN A CB  1 
ATOM   4094 C  CG  . ASN A 1 558 ? -19.057 -51.816 -37.462 1.00 27.02  ? 821  ASN A CG  1 
ATOM   4095 O  OD1 . ASN A 1 558 ? -18.452 -50.842 -37.867 1.00 27.90  ? 821  ASN A OD1 1 
ATOM   4096 N  ND2 . ASN A 1 558 ? -18.451 -52.888 -36.946 1.00 26.22  ? 821  ASN A ND2 1 
ATOM   4097 N  N   . PRO A 1 559 ? -20.357 -48.927 -39.730 1.00 28.61  ? 822  PRO A N   1 
ATOM   4098 C  CA  . PRO A 1 559 ? -19.973 -48.551 -41.083 1.00 32.63  ? 822  PRO A CA  1 
ATOM   4099 C  C   . PRO A 1 559 ? -18.667 -49.189 -41.547 1.00 31.32  ? 822  PRO A C   1 
ATOM   4100 O  O   . PRO A 1 559 ? -18.386 -49.136 -42.708 1.00 33.66  ? 822  PRO A O   1 
ATOM   4101 C  CB  . PRO A 1 559 ? -19.844 -47.023 -41.028 1.00 35.35  ? 822  PRO A CB  1 
ATOM   4102 C  CG  . PRO A 1 559 ? -19.577 -46.739 -39.573 1.00 34.80  ? 822  PRO A CG  1 
ATOM   4103 C  CD  . PRO A 1 559 ? -20.380 -47.776 -38.817 1.00 32.50  ? 822  PRO A CD  1 
ATOM   4104 N  N   . TRP A 1 560 ? -17.890 -49.794 -40.656 1.00 31.64  ? 823  TRP A N   1 
ATOM   4105 C  CA  . TRP A 1 560 ? -16.630 -50.462 -41.089 1.00 32.55  ? 823  TRP A CA  1 
ATOM   4106 C  C   . TRP A 1 560 ? -16.841 -51.951 -41.448 1.00 33.29  ? 823  TRP A C   1 
ATOM   4107 O  O   . TRP A 1 560 ? -15.862 -52.554 -41.821 1.00 38.89  ? 823  TRP A O   1 
ATOM   4108 C  CB  . TRP A 1 560 ? -15.554 -50.281 -40.015 1.00 29.50  ? 823  TRP A CB  1 
ATOM   4109 C  CG  . TRP A 1 560 ? -15.123 -48.854 -39.842 1.00 28.65  ? 823  TRP A CG  1 
ATOM   4110 C  CD1 . TRP A 1 560 ? -14.205 -48.171 -40.597 1.00 28.00  ? 823  TRP A CD1 1 
ATOM   4111 C  CD2 . TRP A 1 560 ? -15.642 -47.916 -38.894 1.00 28.56  ? 823  TRP A CD2 1 
ATOM   4112 N  NE1 . TRP A 1 560 ? -14.097 -46.881 -40.146 1.00 28.84  ? 823  TRP A NE1 1 
ATOM   4113 C  CE2 . TRP A 1 560 ? -14.957 -46.698 -39.092 1.00 27.74  ? 823  TRP A CE2 1 
ATOM   4114 C  CE3 . TRP A 1 560 ? -16.566 -48.011 -37.849 1.00 27.53  ? 823  TRP A CE3 1 
ATOM   4115 C  CZ2 . TRP A 1 560 ? -15.192 -45.577 -38.304 1.00 30.71  ? 823  TRP A CZ2 1 
ATOM   4116 C  CZ3 . TRP A 1 560 ? -16.818 -46.900 -37.088 1.00 27.82  ? 823  TRP A CZ3 1 
ATOM   4117 C  CH2 . TRP A 1 560 ? -16.145 -45.691 -37.320 1.00 29.05  ? 823  TRP A CH2 1 
ATOM   4118 N  N   . MET A 1 561 ? -18.057 -52.507 -41.319 1.00 32.24  ? 824  MET A N   1 
ATOM   4119 C  CA  . MET A 1 561 ? -18.403 -53.945 -41.542 1.00 34.23  ? 824  MET A CA  1 
ATOM   4120 C  C   . MET A 1 561 ? -19.227 -54.009 -42.847 1.00 32.17  ? 824  MET A C   1 
ATOM   4121 O  O   . MET A 1 561 ? -20.399 -53.570 -42.839 1.00 32.73  ? 824  MET A O   1 
ATOM   4122 C  CB  . MET A 1 561 ? -19.221 -54.485 -40.353 1.00 35.58  ? 824  MET A CB  1 
ATOM   4123 C  CG  . MET A 1 561 ? -19.458 -56.032 -40.310 1.00 38.66  ? 824  MET A CG  1 
ATOM   4124 S  SD  . MET A 1 561 ? -17.941 -56.871 -39.955 1.00 54.38  ? 824  MET A SD  1 
ATOM   4125 C  CE  . MET A 1 561 ? -17.902 -56.696 -38.167 1.00 49.97  ? 824  MET A CE  1 
ATOM   4126 N  N   . GLU A 1 562 ? -18.639 -54.457 -43.956 1.00 33.70  ? 825  GLU A N   1 
ATOM   4127 C  CA  . GLU A 1 562 ? -19.357 -54.485 -45.269 1.00 40.16  ? 825  GLU A CA  1 
ATOM   4128 C  C   . GLU A 1 562 ? -20.416 -55.613 -45.264 1.00 35.75  ? 825  GLU A C   1 
ATOM   4129 O  O   . GLU A 1 562 ? -21.556 -55.342 -45.635 1.00 38.82  ? 825  GLU A O   1 
ATOM   4130 C  CB  . GLU A 1 562 ? -18.351 -54.631 -46.409 1.00 44.96  ? 825  GLU A CB  1 
ATOM   4131 C  CG  . GLU A 1 562 ? -18.932 -54.420 -47.790 1.00 56.95  ? 825  GLU A CG  1 
ATOM   4132 C  CD  . GLU A 1 562 ? -17.909 -54.405 -48.929 1.00 69.77  ? 825  GLU A CD  1 
ATOM   4133 O  OE1 . GLU A 1 562 ? -18.342 -54.484 -50.108 1.00 75.94  ? 825  GLU A OE1 1 
ATOM   4134 O  OE2 . GLU A 1 562 ? -16.679 -54.278 -48.649 1.00 75.17  ? 825  GLU A OE2 1 
ATOM   4135 N  N   . ASP A 1 563 ? -20.071 -56.801 -44.782 1.00 35.82  ? 826  ASP A N   1 
ATOM   4136 C  CA  . ASP A 1 563 ? -20.947 -58.002 -44.772 1.00 37.25  ? 826  ASP A CA  1 
ATOM   4137 C  C   . ASP A 1 563 ? -21.906 -57.919 -43.585 1.00 35.59  ? 826  ASP A C   1 
ATOM   4138 O  O   . ASP A 1 563 ? -21.431 -57.913 -42.444 1.00 35.47  ? 826  ASP A O   1 
ATOM   4139 C  CB  . ASP A 1 563 ? -20.080 -59.255 -44.732 1.00 36.33  ? 826  ASP A CB  1 
ATOM   4140 C  CG  . ASP A 1 563 ? -20.886 -60.536 -44.536 1.00 38.48  ? 826  ASP A CG  1 
ATOM   4141 O  OD1 . ASP A 1 563 ? -22.129 -60.449 -44.465 1.00 38.04  ? 826  ASP A OD1 1 
ATOM   4142 O  OD2 . ASP A 1 563 ? -20.253 -61.580 -44.372 1.00 41.03  ? 826  ASP A OD2 1 
ATOM   4143 N  N   . LYS A 1 564 ? -23.209 -57.845 -43.833 1.00 33.67  ? 827  LYS A N   1 
ATOM   4144 C  CA  . LYS A 1 564 ? -24.215 -57.570 -42.780 1.00 31.13  ? 827  LYS A CA  1 
ATOM   4145 C  C   . LYS A 1 564 ? -24.858 -58.877 -42.288 1.00 30.46  ? 827  LYS A C   1 
ATOM   4146 O  O   . LYS A 1 564 ? -25.931 -58.813 -41.633 1.00 30.06  ? 827  LYS A O   1 
ATOM   4147 C  CB  . LYS A 1 564 ? -25.255 -56.568 -43.279 1.00 33.83  ? 827  LYS A CB  1 
ATOM   4148 C  CG  . LYS A 1 564 ? -24.717 -55.196 -43.674 1.00 36.24  ? 827  LYS A CG  1 
ATOM   4149 C  CD  . LYS A 1 564 ? -23.934 -54.516 -42.573 1.00 31.62  ? 827  LYS A CD  1 
ATOM   4150 C  CE  . LYS A 1 564 ? -23.757 -53.034 -42.801 1.00 34.38  ? 827  LYS A CE  1 
ATOM   4151 N  NZ  . LYS A 1 564 ? -22.860 -52.439 -41.766 1.00 33.75  ? 827  LYS A NZ  1 
ATOM   4152 N  N   . THR A 1 565 ? -24.255 -60.029 -42.533 1.00 30.43  ? 828  THR A N   1 
ATOM   4153 C  CA  . THR A 1 565 ? -24.868 -61.307 -42.056 1.00 33.50  ? 828  THR A CA  1 
ATOM   4154 C  C   . THR A 1 565 ? -24.966 -61.272 -40.534 1.00 34.24  ? 828  THR A C   1 
ATOM   4155 O  O   . THR A 1 565 ? -23.926 -61.162 -39.877 1.00 32.93  ? 828  THR A O   1 
ATOM   4156 C  CB  . THR A 1 565 ? -24.045 -62.530 -42.463 1.00 37.22  ? 828  THR A CB  1 
ATOM   4157 O  OG1 . THR A 1 565 ? -23.793 -62.375 -43.851 1.00 38.93  ? 828  THR A OG1 1 
ATOM   4158 C  CG2 . THR A 1 565 ? -24.725 -63.850 -42.198 1.00 37.89  ? 828  THR A CG2 1 
ATOM   4159 N  N   . PRO A 1 566 ? -26.182 -61.405 -39.935 1.00 36.71  ? 829  PRO A N   1 
ATOM   4160 C  CA  . PRO A 1 566 ? -26.330 -61.405 -38.481 1.00 36.74  ? 829  PRO A CA  1 
ATOM   4161 C  C   . PRO A 1 566 ? -25.618 -62.616 -37.878 1.00 37.05  ? 829  PRO A C   1 
ATOM   4162 O  O   . PRO A 1 566 ? -25.432 -63.639 -38.548 1.00 31.30  ? 829  PRO A O   1 
ATOM   4163 C  CB  . PRO A 1 566 ? -27.846 -61.494 -38.235 1.00 39.87  ? 829  PRO A CB  1 
ATOM   4164 C  CG  . PRO A 1 566 ? -28.478 -61.163 -39.570 1.00 38.76  ? 829  PRO A CG  1 
ATOM   4165 C  CD  . PRO A 1 566 ? -27.480 -61.612 -40.606 1.00 38.08  ? 829  PRO A CD  1 
ATOM   4166 N  N   . VAL A 1 567 ? -25.205 -62.469 -36.629 1.00 35.99  ? 830  VAL A N   1 
ATOM   4167 C  CA  . VAL A 1 567 ? -24.624 -63.559 -35.810 1.00 35.63  ? 830  VAL A CA  1 
ATOM   4168 C  C   . VAL A 1 567 ? -25.816 -64.242 -35.133 1.00 33.17  ? 830  VAL A C   1 
ATOM   4169 O  O   . VAL A 1 567 ? -26.720 -63.520 -34.673 1.00 33.75  ? 830  VAL A O   1 
ATOM   4170 C  CB  . VAL A 1 567 ? -23.618 -62.938 -34.824 1.00 38.75  ? 830  VAL A CB  1 
ATOM   4171 C  CG1 . VAL A 1 567 ? -23.551 -63.687 -33.541 1.00 40.75  ? 830  VAL A CG1 1 
ATOM   4172 C  CG2 . VAL A 1 567 ? -22.244 -62.760 -35.451 1.00 37.92  ? 830  VAL A CG2 1 
ATOM   4173 N  N   . GLU A 1 568 ? -25.820 -65.570 -35.082 1.00 35.12  ? 831  GLU A N   1 
ATOM   4174 C  CA  . GLU A 1 568 ? -26.999 -66.373 -34.641 1.00 40.00  ? 831  GLU A CA  1 
ATOM   4175 C  C   . GLU A 1 568 ? -26.840 -66.776 -33.182 1.00 36.96  ? 831  GLU A C   1 
ATOM   4176 O  O   . GLU A 1 568 ? -27.840 -67.128 -32.566 1.00 36.23  ? 831  GLU A O   1 
ATOM   4177 C  CB  . GLU A 1 568 ? -27.126 -67.654 -35.484 1.00 43.30  ? 831  GLU A CB  1 
ATOM   4178 C  CG  . GLU A 1 568 ? -27.519 -67.406 -36.938 1.00 47.88  ? 831  GLU A CG  1 
ATOM   4179 C  CD  . GLU A 1 568 ? -28.842 -66.675 -37.158 1.00 52.19  ? 831  GLU A CD  1 
ATOM   4180 O  OE1 . GLU A 1 568 ? -29.787 -66.864 -36.355 1.00 51.21  ? 831  GLU A OE1 1 
ATOM   4181 O  OE2 . GLU A 1 568 ? -28.938 -65.924 -38.142 1.00 55.28  ? 831  GLU A OE2 1 
ATOM   4182 N  N   . SER A 1 569 ? -25.621 -66.796 -32.637 1.00 31.03  ? 832  SER A N   1 
ATOM   4183 C  CA  . SER A 1 569 ? -25.400 -67.186 -31.222 1.00 28.56  ? 832  SER A CA  1 
ATOM   4184 C  C   . SER A 1 569 ? -24.140 -66.517 -30.659 1.00 29.71  ? 832  SER A C   1 
ATOM   4185 O  O   . SER A 1 569 ? -23.258 -66.055 -31.452 1.00 26.39  ? 832  SER A O   1 
ATOM   4186 C  CB  . SER A 1 569 ? -25.299 -68.691 -31.090 1.00 31.85  ? 832  SER A CB  1 
ATOM   4187 O  OG  . SER A 1 569 ? -24.007 -69.121 -31.457 1.00 32.32  ? 832  SER A OG  1 
ATOM   4188 N  N   . TRP A 1 570 ? -24.058 -66.465 -29.334 1.00 26.65  ? 833  TRP A N   1 
ATOM   4189 C  CA  . TRP A 1 570 ? -22.878 -65.879 -28.656 1.00 29.42  ? 833  TRP A CA  1 
ATOM   4190 C  C   . TRP A 1 570 ? -21.621 -66.692 -29.011 1.00 32.77  ? 833  TRP A C   1 
ATOM   4191 O  O   . TRP A 1 570 ? -20.533 -66.112 -29.061 1.00 27.34  ? 833  TRP A O   1 
ATOM   4192 C  CB  . TRP A 1 570 ? -23.146 -65.775 -27.150 1.00 26.36  ? 833  TRP A CB  1 
ATOM   4193 C  CG  . TRP A 1 570 ? -24.005 -64.624 -26.777 1.00 27.52  ? 833  TRP A CG  1 
ATOM   4194 C  CD1 . TRP A 1 570 ? -25.347 -64.657 -26.516 1.00 27.14  ? 833  TRP A CD1 1 
ATOM   4195 C  CD2 . TRP A 1 570 ? -23.587 -63.242 -26.655 1.00 27.47  ? 833  TRP A CD2 1 
ATOM   4196 N  NE1 . TRP A 1 570 ? -25.786 -63.385 -26.240 1.00 29.88  ? 833  TRP A NE1 1 
ATOM   4197 C  CE2 . TRP A 1 570 ? -24.730 -62.502 -26.315 1.00 26.45  ? 833  TRP A CE2 1 
ATOM   4198 C  CE3 . TRP A 1 570 ? -22.353 -62.568 -26.766 1.00 28.15  ? 833  TRP A CE3 1 
ATOM   4199 C  CZ2 . TRP A 1 570 ? -24.676 -61.125 -26.046 1.00 29.06  ? 833  TRP A CZ2 1 
ATOM   4200 C  CZ3 . TRP A 1 570 ? -22.306 -61.209 -26.552 1.00 26.04  ? 833  TRP A CZ3 1 
ATOM   4201 C  CH2 . TRP A 1 570 ? -23.460 -60.497 -26.194 1.00 27.57  ? 833  TRP A CH2 1 
ATOM   4202 N  N   . GLU A 1 571 ? -21.730 -67.973 -29.359 1.00 31.08  ? 834  GLU A N   1 
ATOM   4203 C  CA  . GLU A 1 571 ? -20.523 -68.802 -29.662 1.00 36.40  ? 834  GLU A CA  1 
ATOM   4204 C  C   . GLU A 1 571 ? -19.815 -68.348 -30.940 1.00 33.17  ? 834  GLU A C   1 
ATOM   4205 O  O   . GLU A 1 571 ? -18.584 -68.593 -31.062 1.00 34.93  ? 834  GLU A O   1 
ATOM   4206 C  CB  . GLU A 1 571 ? -20.896 -70.289 -29.706 1.00 49.70  ? 834  GLU A CB  1 
ATOM   4207 C  CG  . GLU A 1 571 ? -20.986 -70.869 -28.308 1.00 60.83  ? 834  GLU A CG  1 
ATOM   4208 C  CD  . GLU A 1 571 ? -21.326 -72.345 -28.214 1.00 79.13  ? 834  GLU A CD  1 
ATOM   4209 O  OE1 . GLU A 1 571 ? -20.789 -73.131 -29.035 1.00 89.71  ? 834  GLU A OE1 1 
ATOM   4210 O  OE2 . GLU A 1 571 ? -22.132 -72.703 -27.315 1.00 85.89  ? 834  GLU A OE2 1 
ATOM   4211 N  N   . GLU A 1 572 ? -20.500 -67.661 -31.826 1.00 31.70  ? 835  GLU A N   1 
ATOM   4212 C  CA  . GLU A 1 572 ? -19.867 -67.079 -33.036 1.00 34.91  ? 835  GLU A CA  1 
ATOM   4213 C  C   . GLU A 1 572 ? -18.993 -65.859 -32.666 1.00 31.93  ? 835  GLU A C   1 
ATOM   4214 O  O   . GLU A 1 572 ? -18.324 -65.314 -33.579 1.00 32.66  ? 835  GLU A O   1 
ATOM   4215 C  CB  . GLU A 1 572 ? -20.912 -66.523 -34.002 1.00 35.61  ? 835  GLU A CB  1 
ATOM   4216 C  CG  . GLU A 1 572 ? -21.706 -67.570 -34.750 1.00 47.01  ? 835  GLU A CG  1 
ATOM   4217 C  CD  . GLU A 1 572 ? -22.663 -66.965 -35.787 1.00 42.66  ? 835  GLU A CD  1 
ATOM   4218 O  OE1 . GLU A 1 572 ? -22.208 -66.226 -36.679 1.00 46.58  ? 835  GLU A OE1 1 
ATOM   4219 O  OE2 . GLU A 1 572 ? -23.850 -67.206 -35.686 1.00 45.36  ? 835  GLU A OE2 1 
ATOM   4220 N  N   . ILE A 1 573 ? -19.142 -65.323 -31.453 1.00 27.34  ? 836  ILE A N   1 
ATOM   4221 C  CA  . ILE A 1 573 ? -18.531 -64.002 -31.091 1.00 26.93  ? 836  ILE A CA  1 
ATOM   4222 C  C   . ILE A 1 573 ? -17.219 -64.354 -30.398 1.00 25.62  ? 836  ILE A C   1 
ATOM   4223 O  O   . ILE A 1 573 ? -17.207 -65.068 -29.403 1.00 24.09  ? 836  ILE A O   1 
ATOM   4224 C  CB  . ILE A 1 573 ? -19.493 -63.150 -30.240 1.00 28.62  ? 836  ILE A CB  1 
ATOM   4225 C  CG1 . ILE A 1 573 ? -20.741 -62.798 -31.041 1.00 27.18  ? 836  ILE A CG1 1 
ATOM   4226 C  CG2 . ILE A 1 573 ? -18.795 -61.891 -29.723 1.00 29.77  ? 836  ILE A CG2 1 
ATOM   4227 C  CD1 . ILE A 1 573 ? -21.821 -62.122 -30.260 1.00 30.05  ? 836  ILE A CD1 1 
ATOM   4228 N  N   . PRO A 1 574 ? -16.076 -63.899 -30.925 1.00 25.96  ? 837  PRO A N   1 
ATOM   4229 C  CA  . PRO A 1 574 ? -14.780 -64.358 -30.435 1.00 26.12  ? 837  PRO A CA  1 
ATOM   4230 C  C   . PRO A 1 574 ? -14.286 -63.691 -29.136 1.00 24.73  ? 837  PRO A C   1 
ATOM   4231 O  O   . PRO A 1 574 ? -14.825 -62.687 -28.688 1.00 22.86  ? 837  PRO A O   1 
ATOM   4232 C  CB  . PRO A 1 574 ? -13.868 -63.961 -31.604 1.00 26.77  ? 837  PRO A CB  1 
ATOM   4233 C  CG  . PRO A 1 574 ? -14.469 -62.656 -32.083 1.00 28.61  ? 837  PRO A CG  1 
ATOM   4234 C  CD  . PRO A 1 574 ? -15.971 -62.848 -31.953 1.00 27.92  ? 837  PRO A CD  1 
ATOM   4235 N  N   . TYR A 1 575 ? -13.258 -64.300 -28.536 0.46 25.35  ? 838  TYR A N   1 
ATOM   4236 C  CA  . TYR A 1 575 ? -12.474 -63.781 -27.385 0.46 24.16  ? 838  TYR A CA  1 
ATOM   4237 C  C   . TYR A 1 575 ? -11.102 -63.298 -27.895 0.46 24.05  ? 838  TYR A C   1 
ATOM   4238 O  O   . TYR A 1 575 ? -10.679 -63.743 -28.986 0.46 21.97  ? 838  TYR A O   1 
ATOM   4239 C  CB  . TYR A 1 575 ? -12.233 -64.882 -26.346 0.46 25.17  ? 838  TYR A CB  1 
ATOM   4240 C  CG  . TYR A 1 575 ? -13.414 -65.402 -25.556 0.46 25.10  ? 838  TYR A CG  1 
ATOM   4241 C  CD1 . TYR A 1 575 ? -14.114 -64.589 -24.677 0.46 24.25  ? 838  TYR A CD1 1 
ATOM   4242 C  CD2 . TYR A 1 575 ? -13.772 -66.743 -25.610 0.46 26.33  ? 838  TYR A CD2 1 
ATOM   4243 C  CE1 . TYR A 1 575 ? -15.174 -65.078 -23.927 0.46 25.55  ? 838  TYR A CE1 1 
ATOM   4244 C  CE2 . TYR A 1 575 ? -14.822 -67.251 -24.860 0.46 26.09  ? 838  TYR A CE2 1 
ATOM   4245 C  CZ  . TYR A 1 575 ? -15.525 -66.414 -24.011 0.46 25.97  ? 838  TYR A CZ  1 
ATOM   4246 O  OH  . TYR A 1 575 ? -16.564 -66.893 -23.269 0.46 26.31  ? 838  TYR A OH  1 
ATOM   4247 N  N   . LEU A 1 576 ? -10.414 -62.443 -27.125 1.00 21.42  ? 839  LEU A N   1 
ATOM   4248 C  CA  . LEU A 1 576 ? -8.966  -62.201 -27.294 1.00 21.55  ? 839  LEU A CA  1 
ATOM   4249 C  C   . LEU A 1 576 ? -8.260  -63.569 -27.217 1.00 22.54  ? 839  LEU A C   1 
ATOM   4250 O  O   . LEU A 1 576 ? -8.816  -64.502 -26.598 1.00 21.09  ? 839  LEU A O   1 
ATOM   4251 C  CB  . LEU A 1 576 ? -8.454  -61.313 -26.152 1.00 21.83  ? 839  LEU A CB  1 
ATOM   4252 C  CG  . LEU A 1 576 ? -9.062  -59.908 -26.048 1.00 20.73  ? 839  LEU A CG  1 
ATOM   4253 C  CD1 . LEU A 1 576 ? -8.397  -59.143 -24.913 1.00 22.76  ? 839  LEU A CD1 1 
ATOM   4254 C  CD2 . LEU A 1 576 ? -8.928  -59.151 -27.338 1.00 24.11  ? 839  LEU A CD2 1 
ATOM   4255 N  N   . GLY A 1 577 ? -7.053  -63.693 -27.755 1.00 23.48  ? 840  GLY A N   1 
ATOM   4256 C  CA  . GLY A 1 577 ? -6.170  -64.825 -27.382 1.00 24.27  ? 840  GLY A CA  1 
ATOM   4257 C  C   . GLY A 1 577 ? -6.089  -64.984 -25.874 1.00 22.81  ? 840  GLY A C   1 
ATOM   4258 O  O   . GLY A 1 577 ? -6.191  -63.994 -25.135 1.00 21.41  ? 840  GLY A O   1 
ATOM   4259 N  N   . LYS A 1 578 ? -5.881  -66.211 -25.399 0.46 22.54  ? 841  LYS A N   1 
ATOM   4260 C  CA  . LYS A 1 578 ? -5.848  -66.480 -23.938 0.46 23.31  ? 841  LYS A CA  1 
ATOM   4261 C  C   . LYS A 1 578 ? -4.667  -65.751 -23.283 0.46 21.79  ? 841  LYS A C   1 
ATOM   4262 O  O   . LYS A 1 578 ? -4.839  -65.296 -22.148 0.46 20.46  ? 841  LYS A O   1 
ATOM   4263 C  CB  . LYS A 1 578 ? -5.795  -67.976 -23.632 0.46 25.20  ? 841  LYS A CB  1 
ATOM   4264 C  CG  . LYS A 1 578 ? -6.243  -68.321 -22.218 0.46 26.60  ? 841  LYS A CG  1 
ATOM   4265 C  CD  . LYS A 1 578 ? -6.280  -69.810 -21.921 0.46 28.61  ? 841  LYS A CD  1 
ATOM   4266 C  CE  . LYS A 1 578 ? -5.140  -70.267 -21.037 0.46 29.53  ? 841  LYS A CE  1 
ATOM   4267 N  NZ  . LYS A 1 578 ? -5.516  -71.462 -20.249 0.46 29.95  ? 841  LYS A NZ  1 
ATOM   4268 N  N   . ARG A 1 579 ? -3.516  -65.647 -23.952 1.00 21.02  ? 842  ARG A N   1 
ATOM   4269 C  CA  . ARG A 1 579 ? -2.351  -64.939 -23.379 1.00 21.66  ? 842  ARG A CA  1 
ATOM   4270 C  C   . ARG A 1 579 ? -2.642  -63.422 -23.354 1.00 21.19  ? 842  ARG A C   1 
ATOM   4271 O  O   . ARG A 1 579 ? -2.314  -62.773 -22.334 1.00 20.65  ? 842  ARG A O   1 
ATOM   4272 C  CB  . ARG A 1 579 ? -1.062  -65.313 -24.131 1.00 20.94  ? 842  ARG A CB  1 
ATOM   4273 C  CG  . ARG A 1 579 ? 0.153   -64.806 -23.401 1.00 22.71  ? 842  ARG A CG  1 
ATOM   4274 C  CD  . ARG A 1 579 ? 1.476   -65.089 -24.133 1.00 26.82  ? 842  ARG A CD  1 
ATOM   4275 N  NE  . ARG A 1 579 ? 1.557   -66.534 -24.284 1.00 29.00  ? 842  ARG A NE  1 
ATOM   4276 C  CZ  . ARG A 1 579 ? 1.853   -67.378 -23.323 1.00 34.42  ? 842  ARG A CZ  1 
ATOM   4277 N  NH1 . ARG A 1 579 ? 1.794   -68.679 -23.564 1.00 42.46  ? 842  ARG A NH1 1 
ATOM   4278 N  NH2 . ARG A 1 579 ? 2.184   -66.945 -22.131 1.00 35.83  ? 842  ARG A NH2 1 
ATOM   4279 N  N   . GLU A 1 580 ? -3.216  -62.876 -24.401 1.00 20.53  ? 843  GLU A N   1 
ATOM   4280 C  CA  . GLU A 1 580 ? -3.616  -61.431 -24.452 1.00 22.66  ? 843  GLU A CA  1 
ATOM   4281 C  C   . GLU A 1 580 ? -4.645  -61.124 -23.336 1.00 20.14  ? 843  GLU A C   1 
ATOM   4282 O  O   . GLU A 1 580 ? -4.569  -60.084 -22.733 1.00 19.21  ? 843  GLU A O   1 
ATOM   4283 C  CB  . GLU A 1 580 ? -4.244  -61.060 -25.796 1.00 24.26  ? 843  GLU A CB  1 
ATOM   4284 C  CG  . GLU A 1 580 ? -3.450  -61.418 -27.013 1.00 30.34  ? 843  GLU A CG  1 
ATOM   4285 C  CD  . GLU A 1 580 ? -4.175  -60.995 -28.292 1.00 36.74  ? 843  GLU A CD  1 
ATOM   4286 O  OE1 . GLU A 1 580 ? -5.216  -61.619 -28.687 1.00 33.80  ? 843  GLU A OE1 1 
ATOM   4287 O  OE2 . GLU A 1 580 ? -3.769  -59.967 -28.841 1.00 38.56  ? 843  GLU A OE2 1 
ATOM   4288 N  N   . ASP A 1 581 ? -5.546  -62.054 -23.031 1.00 20.81  ? 844  ASP A N   1 
ATOM   4289 C  CA  . ASP A 1 581 ? -6.621  -61.892 -22.019 1.00 21.05  ? 844  ASP A CA  1 
ATOM   4290 C  C   . ASP A 1 581 ? -5.951  -61.804 -20.650 1.00 21.67  ? 844  ASP A C   1 
ATOM   4291 O  O   . ASP A 1 581 ? -6.217  -60.853 -19.907 1.00 20.07  ? 844  ASP A O   1 
ATOM   4292 C  CB  . ASP A 1 581 ? -7.640  -63.032 -22.137 1.00 20.72  ? 844  ASP A CB  1 
ATOM   4293 C  CG  . ASP A 1 581 ? -9.048  -62.691 -21.647 1.00 20.38  ? 844  ASP A CG  1 
ATOM   4294 O  OD1 . ASP A 1 581 ? -9.214  -61.639 -20.988 1.00 20.18  ? 844  ASP A OD1 1 
ATOM   4295 O  OD2 . ASP A 1 581 ? -9.967  -63.526 -21.900 1.00 19.15  ? 844  ASP A OD2 1 
ATOM   4296 N  N   . GLN A 1 582 ? -4.952  -62.661 -20.401 1.00 20.67  ? 845  GLN A N   1 
ATOM   4297 C  CA  . GLN A 1 582 ? -4.144  -62.637 -19.166 1.00 21.12  ? 845  GLN A CA  1 
ATOM   4298 C  C   . GLN A 1 582 ? -3.344  -61.334 -19.102 1.00 19.02  ? 845  GLN A C   1 
ATOM   4299 O  O   . GLN A 1 582 ? -3.363  -60.680 -18.019 1.00 20.56  ? 845  GLN A O   1 
ATOM   4300 C  CB  . GLN A 1 582 ? -3.195  -63.872 -19.087 1.00 22.21  ? 845  GLN A CB  1 
ATOM   4301 C  CG  . GLN A 1 582 ? -3.920  -65.186 -18.956 1.00 24.91  ? 845  GLN A CG  1 
ATOM   4302 C  CD  . GLN A 1 582 ? -2.956  -66.357 -19.101 1.00 28.30  ? 845  GLN A CD  1 
ATOM   4303 O  OE1 . GLN A 1 582 ? -1.929  -66.253 -19.736 1.00 27.55  ? 845  GLN A OE1 1 
ATOM   4304 N  NE2 . GLN A 1 582 ? -3.250  -67.460 -18.448 1.00 27.44  ? 845  GLN A NE2 1 
ATOM   4305 N  N   . TRP A 1 583 ? -2.687  -60.921 -20.200 1.00 18.56  ? 846  TRP A N   1 
ATOM   4306 C  CA  . TRP A 1 583 ? -1.903  -59.645 -20.244 1.00 17.62  ? 846  TRP A CA  1 
ATOM   4307 C  C   . TRP A 1 583 ? -2.787  -58.464 -19.821 1.00 19.61  ? 846  TRP A C   1 
ATOM   4308 O  O   . TRP A 1 583 ? -2.328  -57.561 -19.055 1.00 19.59  ? 846  TRP A O   1 
ATOM   4309 C  CB  . TRP A 1 583 ? -1.336  -59.382 -21.638 1.00 19.12  ? 846  TRP A CB  1 
ATOM   4310 C  CG  . TRP A 1 583 ? -0.148  -60.240 -22.000 1.00 20.43  ? 846  TRP A CG  1 
ATOM   4311 C  CD1 . TRP A 1 583 ? 0.659   -60.929 -21.154 1.00 20.98  ? 846  TRP A CD1 1 
ATOM   4312 C  CD2 . TRP A 1 583 ? 0.341   -60.516 -23.321 1.00 20.05  ? 846  TRP A CD2 1 
ATOM   4313 N  NE1 . TRP A 1 583 ? 1.634   -61.604 -21.853 1.00 22.18  ? 846  TRP A NE1 1 
ATOM   4314 C  CE2 . TRP A 1 583 ? 1.487   -61.343 -23.185 1.00 21.21  ? 846  TRP A CE2 1 
ATOM   4315 C  CE3 . TRP A 1 583 ? -0.011  -60.078 -24.588 1.00 23.09  ? 846  TRP A CE3 1 
ATOM   4316 C  CZ2 . TRP A 1 583 ? 2.216   -61.797 -24.282 1.00 25.13  ? 846  TRP A CZ2 1 
ATOM   4317 C  CZ3 . TRP A 1 583 ? 0.686   -60.561 -25.682 1.00 24.99  ? 846  TRP A CZ3 1 
ATOM   4318 C  CH2 . TRP A 1 583 ? 1.786   -61.398 -25.528 1.00 24.24  ? 846  TRP A CH2 1 
ATOM   4319 N  N   . CYS A 1 584 ? -4.074  -58.514 -20.210 1.00 19.02  ? 847  CYS A N   1 
ATOM   4320 C  CA  . CYS A 1 584 ? -5.007  -57.409 -19.858 1.00 19.83  ? 847  CYS A CA  1 
ATOM   4321 C  C   . CYS A 1 584 ? -5.779  -57.670 -18.550 1.00 20.15  ? 847  CYS A C   1 
ATOM   4322 O  O   . CYS A 1 584 ? -6.830  -57.046 -18.367 1.00 21.30  ? 847  CYS A O   1 
ATOM   4323 C  CB  . CYS A 1 584 ? -5.880  -57.112 -21.050 1.00 21.75  ? 847  CYS A CB  1 
ATOM   4324 S  SG  . CYS A 1 584 ? -4.981  -56.363 -22.430 1.00 21.41  ? 847  CYS A SG  1 
ATOM   4325 N  N   . GLY A 1 585 ? -5.306  -58.588 -17.699 1.00 20.41  ? 848  GLY A N   1 
ATOM   4326 C  CA  . GLY A 1 585 ? -5.891  -58.773 -16.351 1.00 18.89  ? 848  GLY A CA  1 
ATOM   4327 C  C   . GLY A 1 585 ? -6.686  -60.044 -16.067 1.00 18.74  ? 848  GLY A C   1 
ATOM   4328 O  O   . GLY A 1 585 ? -7.071  -60.214 -14.921 1.00 22.41  ? 848  GLY A O   1 
ATOM   4329 N  N   . SER A 1 586 ? -6.932  -60.899 -17.057 1.00 19.47  ? 849  SER A N   1 
ATOM   4330 C  CA  . SER A 1 586 ? -7.783  -62.098 -16.817 1.00 20.98  ? 849  SER A CA  1 
ATOM   4331 C  C   . SER A 1 586 ? -7.207  -62.987 -15.710 1.00 23.22  ? 849  SER A C   1 
ATOM   4332 O  O   . SER A 1 586 ? -5.984  -63.053 -15.594 1.00 20.90  ? 849  SER A O   1 
ATOM   4333 C  CB  . SER A 1 586 ? -7.993  -62.929 -18.056 1.00 20.42  ? 849  SER A CB  1 
ATOM   4334 O  OG  . SER A 1 586 ? -8.857  -64.019 -17.805 1.00 20.62  ? 849  SER A OG  1 
ATOM   4335 N  N   . LEU A 1 587 ? -8.084  -63.658 -14.963 0.46 21.85  ? 850  LEU A N   1 
ATOM   4336 C  CA  . LEU A 1 587 ? -7.635  -64.626 -13.932 0.46 23.03  ? 850  LEU A CA  1 
ATOM   4337 C  C   . LEU A 1 587 ? -7.698  -66.037 -14.527 0.46 23.41  ? 850  LEU A C   1 
ATOM   4338 O  O   . LEU A 1 587 ? -7.525  -66.999 -13.775 0.46 24.47  ? 850  LEU A O   1 
ATOM   4339 C  CB  . LEU A 1 587 ? -8.539  -64.511 -12.701 0.46 23.79  ? 850  LEU A CB  1 
ATOM   4340 C  CG  . LEU A 1 587 ? -8.523  -63.165 -11.980 0.46 25.37  ? 850  LEU A CG  1 
ATOM   4341 C  CD1 . LEU A 1 587 ? -9.206  -63.280 -10.626 0.46 25.55  ? 850  LEU A CD1 1 
ATOM   4342 C  CD2 . LEU A 1 587 ? -7.100  -62.658 -11.811 0.46 26.33  ? 850  LEU A CD2 1 
ATOM   4343 N  N   . ILE A 1 588 ? -7.946  -66.138 -15.835 0.46 22.96  ? 851  ILE A N   1 
ATOM   4344 C  CA  . ILE A 1 588 ? -7.986  -67.468 -16.507 0.46 25.34  ? 851  ILE A CA  1 
ATOM   4345 C  C   . ILE A 1 588 ? -6.664  -68.187 -16.209 0.46 25.77  ? 851  ILE A C   1 
ATOM   4346 O  O   . ILE A 1 588 ? -5.607  -67.558 -16.352 0.46 23.38  ? 851  ILE A O   1 
ATOM   4347 C  CB  . ILE A 1 588 ? -8.266  -67.328 -18.019 0.46 27.43  ? 851  ILE A CB  1 
ATOM   4348 C  CG1 . ILE A 1 588 ? -8.611  -68.672 -18.665 0.46 28.88  ? 851  ILE A CG1 1 
ATOM   4349 C  CG2 . ILE A 1 588 ? -7.118  -66.632 -18.735 0.46 27.03  ? 851  ILE A CG2 1 
ATOM   4350 C  CD1 . ILE A 1 588 ? -9.942  -69.234 -18.232 0.46 30.22  ? 851  ILE A CD1 1 
ATOM   4351 N  N   . GLY A 1 589 ? -6.736  -69.438 -15.756 0.46 27.73  ? 852  GLY A N   1 
ATOM   4352 C  CA  . GLY A 1 589 ? -5.514  -70.174 -15.370 0.46 27.78  ? 852  GLY A CA  1 
ATOM   4353 C  C   . GLY A 1 589 ? -5.353  -70.297 -13.864 0.46 28.59  ? 852  GLY A C   1 
ATOM   4354 O  O   . GLY A 1 589 ? -4.595  -71.174 -13.434 0.46 27.91  ? 852  GLY A O   1 
ATOM   4355 N  N   . LEU A 1 590 ? -6.045  -69.459 -13.094 0.46 28.38  ? 853  LEU A N   1 
ATOM   4356 C  CA  . LEU A 1 590 ? -5.953  -69.502 -11.610 0.46 28.93  ? 853  LEU A CA  1 
ATOM   4357 C  C   . LEU A 1 590 ? -6.947  -70.541 -11.076 0.46 30.28  ? 853  LEU A C   1 
ATOM   4358 O  O   . LEU A 1 590 ? -8.064  -70.613 -11.621 0.46 26.25  ? 853  LEU A O   1 
ATOM   4359 C  CB  . LEU A 1 590 ? -6.238  -68.112 -11.034 0.46 30.39  ? 853  LEU A CB  1 
ATOM   4360 C  CG  . LEU A 1 590 ? -5.103  -67.097 -11.155 0.46 33.29  ? 853  LEU A CG  1 
ATOM   4361 C  CD1 . LEU A 1 590 ? -5.512  -65.759 -10.565 0.46 34.99  ? 853  LEU A CD1 1 
ATOM   4362 C  CD2 . LEU A 1 590 ? -3.843  -67.610 -10.476 0.46 33.95  ? 853  LEU A CD2 1 
ATOM   4363 N  N   . THR A 1 591 ? -6.556  -71.301 -10.048 0.46 30.88  ? 854  THR A N   1 
ATOM   4364 C  CA  . THR A 1 591 ? -7.454  -72.316 -9.440  0.46 31.56  ? 854  THR A CA  1 
ATOM   4365 C  C   . THR A 1 591 ? -8.752  -71.621 -9.031  0.46 29.79  ? 854  THR A C   1 
ATOM   4366 O  O   . THR A 1 591 ? -9.826  -72.127 -9.380  0.46 28.94  ? 854  THR A O   1 
ATOM   4367 C  CB  . THR A 1 591 ? -6.754  -72.963 -8.237  0.46 32.78  ? 854  THR A CB  1 
ATOM   4368 O  OG1 . THR A 1 591 ? -5.414  -73.279 -8.611  0.46 35.17  ? 854  THR A OG1 1 
ATOM   4369 C  CG2 . THR A 1 591 ? -7.456  -74.208 -7.744  0.46 35.48  ? 854  THR A CG2 1 
ATOM   4370 N  N   . SER A 1 592 ? -8.641  -70.510 -8.317  0.46 29.51  ? 855  SER A N   1 
ATOM   4371 C  CA  . SER A 1 592 ? -9.795  -69.689 -7.846  0.46 29.39  ? 855  SER A CA  1 
ATOM   4372 C  C   . SER A 1 592 ? -10.789 -69.428 -8.987  0.46 28.30  ? 855  SER A C   1 
ATOM   4373 O  O   . SER A 1 592 ? -11.991 -69.708 -8.814  0.46 28.30  ? 855  SER A O   1 
ATOM   4374 C  CB  . SER A 1 592 ? -9.325  -68.395 -7.230  0.46 29.75  ? 855  SER A CB  1 
ATOM   4375 O  OG  . SER A 1 592 ? -8.563  -67.628 -8.152  0.46 31.68  ? 855  SER A OG  1 
ATOM   4376 N  N   . ARG A 1 593 ? -10.310 -68.899 -10.110 0.46 28.09  ? 856  ARG A N   1 
ATOM   4377 C  CA  . ARG A 1 593 ? -11.164 -68.584 -11.282 0.46 27.14  ? 856  ARG A CA  1 
ATOM   4378 C  C   . ARG A 1 593 ? -11.817 -69.884 -11.771 0.46 26.69  ? 856  ARG A C   1 
ATOM   4379 O  O   . ARG A 1 593 ? -12.984 -69.840 -12.194 0.46 23.47  ? 856  ARG A O   1 
ATOM   4380 C  CB  . ARG A 1 593 ? -10.332 -67.905 -12.371 0.46 26.44  ? 856  ARG A CB  1 
ATOM   4381 C  CG  . ARG A 1 593 ? -11.146 -67.277 -13.494 0.46 26.54  ? 856  ARG A CG  1 
ATOM   4382 C  CD  . ARG A 1 593 ? -11.564 -68.248 -14.581 0.46 26.24  ? 856  ARG A CD  1 
ATOM   4383 N  NE  . ARG A 1 593 ? -12.059 -67.512 -15.736 0.46 25.89  ? 856  ARG A NE  1 
ATOM   4384 C  CZ  . ARG A 1 593 ? -12.809 -68.019 -16.712 0.46 26.30  ? 856  ARG A CZ  1 
ATOM   4385 N  NH1 . ARG A 1 593 ? -13.158 -69.297 -16.706 0.46 25.69  ? 856  ARG A NH1 1 
ATOM   4386 N  NH2 . ARG A 1 593 ? -13.218 -67.230 -17.693 0.46 25.33  ? 856  ARG A NH2 1 
ATOM   4387 N  N   . ALA A 1 594 ? -11.080 -70.998 -11.750 1.00 25.22  ? 857  ALA A N   1 
ATOM   4388 C  CA  . ALA A 1 594 ? -11.637 -72.299 -12.172 1.00 28.47  ? 857  ALA A CA  1 
ATOM   4389 C  C   . ALA A 1 594 ? -12.783 -72.720 -11.229 1.00 25.69  ? 857  ALA A C   1 
ATOM   4390 O  O   . ALA A 1 594 ? -13.824 -73.217 -11.706 1.00 28.11  ? 857  ALA A O   1 
ATOM   4391 C  CB  . ALA A 1 594 ? -10.535 -73.343 -12.200 1.00 34.03  ? 857  ALA A CB  1 
ATOM   4392 N  N   . THR A 1 595 ? -12.625 -72.541 -9.925  1.00 26.42  ? 858  THR A N   1 
ATOM   4393 C  CA  . THR A 1 595 ? -13.657 -72.953 -8.963  1.00 30.56  ? 858  THR A CA  1 
ATOM   4394 C  C   . THR A 1 595 ? -14.886 -72.039 -9.119  1.00 30.86  ? 858  THR A C   1 
ATOM   4395 O  O   . THR A 1 595 ? -16.039 -72.515 -9.051  1.00 26.68  ? 858  THR A O   1 
ATOM   4396 C  CB  . THR A 1 595 ? -13.131 -72.854 -7.533  1.00 34.10  ? 858  THR A CB  1 
ATOM   4397 O  OG1 . THR A 1 595 ? -11.966 -73.686 -7.462  1.00 41.97  ? 858  THR A OG1 1 
ATOM   4398 C  CG2 . THR A 1 595 ? -14.182 -73.296 -6.542  1.00 35.08  ? 858  THR A CG2 1 
ATOM   4399 N  N   . TRP A 1 596 ? -14.637 -70.743 -9.263  1.00 25.23  ? 859  TRP A N   1 
ATOM   4400 C  CA  . TRP A 1 596 ? -15.725 -69.753 -9.527  1.00 22.59  ? 859  TRP A CA  1 
ATOM   4401 C  C   . TRP A 1 596 ? -16.515 -70.186 -10.761 1.00 21.24  ? 859  TRP A C   1 
ATOM   4402 O  O   . TRP A 1 596 ? -17.778 -70.266 -10.678 1.00 24.32  ? 859  TRP A O   1 
ATOM   4403 C  CB  . TRP A 1 596 ? -15.091 -68.351 -9.652  1.00 22.61  ? 859  TRP A CB  1 
ATOM   4404 C  CG  . TRP A 1 596 ? -15.985 -67.250 -10.133 1.00 20.64  ? 859  TRP A CG  1 
ATOM   4405 C  CD1 . TRP A 1 596 ? -17.027 -66.678 -9.474  1.00 21.97  ? 859  TRP A CD1 1 
ATOM   4406 C  CD2 . TRP A 1 596 ? -15.878 -66.575 -11.386 1.00 21.88  ? 859  TRP A CD2 1 
ATOM   4407 N  NE1 . TRP A 1 596 ? -17.556 -65.654 -10.224 1.00 21.30  ? 859  TRP A NE1 1 
ATOM   4408 C  CE2 . TRP A 1 596 ? -16.893 -65.588 -11.412 1.00 21.01  ? 859  TRP A CE2 1 
ATOM   4409 C  CE3 . TRP A 1 596 ? -15.026 -66.708 -12.495 1.00 23.48  ? 859  TRP A CE3 1 
ATOM   4410 C  CZ2 . TRP A 1 596 ? -17.042 -64.706 -12.479 1.00 22.20  ? 859  TRP A CZ2 1 
ATOM   4411 C  CZ3 . TRP A 1 596 ? -15.159 -65.827 -13.548 1.00 24.35  ? 859  TRP A CZ3 1 
ATOM   4412 C  CH2 . TRP A 1 596 ? -16.170 -64.837 -13.527 1.00 25.68  ? 859  TRP A CH2 1 
ATOM   4413 N  N   . ALA A 1 597 ? -15.853 -70.397 -11.886 1.00 23.81  ? 860  ALA A N   1 
ATOM   4414 C  CA  . ALA A 1 597 ? -16.532 -70.742 -13.163 1.00 26.27  ? 860  ALA A CA  1 
ATOM   4415 C  C   . ALA A 1 597 ? -17.349 -72.038 -13.007 1.00 29.30  ? 860  ALA A C   1 
ATOM   4416 O  O   . ALA A 1 597 ? -18.546 -72.067 -13.353 1.00 26.44  ? 860  ALA A O   1 
ATOM   4417 C  CB  . ALA A 1 597 ? -15.538 -70.836 -14.272 1.00 23.11  ? 860  ALA A CB  1 
ATOM   4418 N  N   . LYS A 1 598 ? -16.730 -73.085 -12.461 0.46 29.45  ? 861  LYS A N   1 
ATOM   4419 C  CA  . LYS A 1 598 ? -17.380 -74.418 -12.337 0.46 31.61  ? 861  LYS A CA  1 
ATOM   4420 C  C   . LYS A 1 598 ? -18.597 -74.328 -11.408 0.46 29.52  ? 861  LYS A C   1 
ATOM   4421 O  O   . LYS A 1 598 ? -19.613 -74.970 -11.731 0.46 30.09  ? 861  LYS A O   1 
ATOM   4422 C  CB  . LYS A 1 598 ? -16.394 -75.476 -11.836 0.46 34.23  ? 861  LYS A CB  1 
ATOM   4423 C  CG  . LYS A 1 598 ? -16.907 -76.907 -11.939 0.46 38.74  ? 861  LYS A CG  1 
ATOM   4424 C  CD  . LYS A 1 598 ? -16.184 -77.897 -11.043 0.46 42.47  ? 861  LYS A CD  1 
ATOM   4425 C  CE  . LYS A 1 598 ? -16.565 -79.335 -11.336 0.46 43.75  ? 861  LYS A CE  1 
ATOM   4426 N  NZ  . LYS A 1 598 ? -18.029 -79.501 -11.500 0.46 43.33  ? 861  LYS A NZ  1 
ATOM   4427 N  N   . ASN A 1 599 ? -18.512 -73.557 -10.316 1.00 28.87  ? 862  ASN A N   1 
ATOM   4428 C  CA  . ASN A 1 599 ? -19.596 -73.466 -9.301  1.00 28.44  ? 862  ASN A CA  1 
ATOM   4429 C  C   . ASN A 1 599 ? -20.488 -72.236 -9.509  1.00 24.63  ? 862  ASN A C   1 
ATOM   4430 O  O   . ASN A 1 599 ? -21.169 -71.850 -8.567  1.00 26.59  ? 862  ASN A O   1 
ATOM   4431 C  CB  . ASN A 1 599 ? -19.003 -73.498 -7.893  1.00 28.52  ? 862  ASN A CB  1 
ATOM   4432 C  CG  . ASN A 1 599 ? -18.329 -74.837 -7.643  1.00 34.04  ? 862  ASN A CG  1 
ATOM   4433 O  OD1 . ASN A 1 599 ? -18.918 -75.892 -7.836  1.00 35.90  ? 862  ASN A OD1 1 
ATOM   4434 N  ND2 . ASN A 1 599 ? -17.065 -74.815 -7.350  1.00 37.00  ? 862  ASN A ND2 1 
ATOM   4435 N  N   . ILE A 1 600 ? -20.543 -71.662 -10.703 1.00 25.95  ? 863  ILE A N   1 
ATOM   4436 C  CA  . ILE A 1 600 ? -21.184 -70.316 -10.870 1.00 22.68  ? 863  ILE A CA  1 
ATOM   4437 C  C   . ILE A 1 600 ? -22.700 -70.397 -10.557 1.00 23.60  ? 863  ILE A C   1 
ATOM   4438 O  O   . ILE A 1 600 ? -23.257 -69.426 -10.046 1.00 21.76  ? 863  ILE A O   1 
ATOM   4439 C  CB  . ILE A 1 600 ? -20.876 -69.732 -12.259 1.00 21.90  ? 863  ILE A CB  1 
ATOM   4440 C  CG1 . ILE A 1 600 ? -21.190 -68.233 -12.355 1.00 26.08  ? 863  ILE A CG1 1 
ATOM   4441 C  CG2 . ILE A 1 600 ? -21.563 -70.513 -13.378 1.00 24.70  ? 863  ILE A CG2 1 
ATOM   4442 C  CD1 . ILE A 1 600 ? -20.337 -67.385 -11.467 1.00 23.89  ? 863  ILE A CD1 1 
ATOM   4443 N  N   A GLN A 1 601 ? -23.344 -71.540 -10.830 0.21 23.28  ? 864  GLN A N   1 
ATOM   4444 N  N   B GLN A 1 601 ? -23.336 -71.543 -10.831 0.20 23.58  ? 864  GLN A N   1 
ATOM   4445 C  CA  A GLN A 1 601 ? -24.806 -71.712 -10.588 0.21 23.89  ? 864  GLN A CA  1 
ATOM   4446 C  CA  B GLN A 1 601 ? -24.792 -71.739 -10.586 0.20 24.35  ? 864  GLN A CA  1 
ATOM   4447 C  C   A GLN A 1 601 ? -25.098 -71.567 -9.086  0.21 24.39  ? 864  GLN A C   1 
ATOM   4448 C  C   B GLN A 1 601 ? -25.089 -71.560 -9.091  0.20 24.64  ? 864  GLN A C   1 
ATOM   4449 O  O   A GLN A 1 601 ? -26.180 -71.062 -8.744  0.21 24.30  ? 864  GLN A O   1 
ATOM   4450 O  O   B GLN A 1 601 ? -26.168 -71.036 -8.762  0.20 24.58  ? 864  GLN A O   1 
ATOM   4451 C  CB  A GLN A 1 601 ? -25.315 -73.039 -11.160 0.21 25.04  ? 864  GLN A CB  1 
ATOM   4452 C  CB  B GLN A 1 601 ? -25.264 -73.103 -11.093 0.20 25.77  ? 864  GLN A CB  1 
ATOM   4453 C  CG  A GLN A 1 601 ? -25.304 -73.095 -12.685 0.21 24.48  ? 864  GLN A CG  1 
ATOM   4454 C  CG  B GLN A 1 601 ? -26.779 -73.208 -11.187 0.20 25.69  ? 864  GLN A CG  1 
ATOM   4455 C  CD  A GLN A 1 601 ? -26.293 -72.171 -13.349 0.21 25.46  ? 864  GLN A CD  1 
ATOM   4456 C  CD  B GLN A 1 601 ? -27.389 -72.105 -12.014 0.20 26.56  ? 864  GLN A CD  1 
ATOM   4457 O  OE1 A GLN A 1 601 ? -27.212 -71.650 -12.722 0.21 27.16  ? 864  GLN A OE1 1 
ATOM   4458 O  OE1 B GLN A 1 601 ? -26.909 -71.770 -13.096 0.20 26.24  ? 864  GLN A OE1 1 
ATOM   4459 N  NE2 A GLN A 1 601 ? -26.119 -71.970 -14.645 0.21 26.24  ? 864  GLN A NE2 1 
ATOM   4460 N  NE2 B GLN A 1 601 ? -28.471 -71.535 -11.506 0.20 27.29  ? 864  GLN A NE2 1 
ATOM   4461 N  N   . THR A 1 602 ? -24.168 -71.978 -8.224  1.00 24.14  ? 865  THR A N   1 
ATOM   4462 C  CA  . THR A 1 602 ? -24.299 -71.797 -6.750  1.00 26.56  ? 865  THR A CA  1 
ATOM   4463 C  C   . THR A 1 602 ? -24.264 -70.306 -6.358  1.00 26.23  ? 865  THR A C   1 
ATOM   4464 O  O   . THR A 1 602 ? -24.972 -69.907 -5.390  1.00 25.15  ? 865  THR A O   1 
ATOM   4465 C  CB  . THR A 1 602 ? -23.194 -72.586 -6.042  1.00 30.10  ? 865  THR A CB  1 
ATOM   4466 O  OG1 . THR A 1 602 ? -23.339 -73.923 -6.540  1.00 35.95  ? 865  THR A OG1 1 
ATOM   4467 C  CG2 . THR A 1 602 ? -23.299 -72.529 -4.541  1.00 36.34  ? 865  THR A CG2 1 
ATOM   4468 N  N   . ALA A 1 603 ? -23.439 -69.498 -7.016  1.00 26.20  ? 866  ALA A N   1 
ATOM   4469 C  CA  . ALA A 1 603 ? -23.329 -68.044 -6.737  1.00 23.80  ? 866  ALA A CA  1 
ATOM   4470 C  C   . ALA A 1 603 ? -24.591 -67.385 -7.227  1.00 20.86  ? 866  ALA A C   1 
ATOM   4471 O  O   . ALA A 1 603 ? -25.174 -66.592 -6.496  1.00 22.10  ? 866  ALA A O   1 
ATOM   4472 C  CB  . ALA A 1 603 ? -22.152 -67.446 -7.445  1.00 24.32  ? 866  ALA A CB  1 
ATOM   4473 N  N   . ILE A 1 604 ? -25.007 -67.736 -8.448  1.00 24.64  ? 867  ILE A N   1 
ATOM   4474 C  CA  . ILE A 1 604 ? -26.263 -67.223 -9.053  1.00 23.84  ? 867  ILE A CA  1 
ATOM   4475 C  C   . ILE A 1 604 ? -27.420 -67.532 -8.099  1.00 23.67  ? 867  ILE A C   1 
ATOM   4476 O  O   . ILE A 1 604 ? -28.217 -66.621 -7.842  1.00 22.87  ? 867  ILE A O   1 
ATOM   4477 C  CB  . ILE A 1 604 ? -26.460 -67.808 -10.461 1.00 24.81  ? 867  ILE A CB  1 
ATOM   4478 C  CG1 . ILE A 1 604 ? -25.457 -67.222 -11.452 1.00 21.94  ? 867  ILE A CG1 1 
ATOM   4479 C  CG2 . ILE A 1 604 ? -27.888 -67.604 -10.940 1.00 26.30  ? 867  ILE A CG2 1 
ATOM   4480 C  CD1 . ILE A 1 604 ? -25.358 -68.009 -12.715 1.00 23.24  ? 867  ILE A CD1 1 
ATOM   4481 N  N   . ASN A 1 605 ? -27.498 -68.766 -7.563  1.00 24.53  ? 868  ASN A N   1 
ATOM   4482 C  CA  . ASN A 1 605 ? -28.604 -69.185 -6.660  1.00 26.83  ? 868  ASN A CA  1 
ATOM   4483 C  C   . ASN A 1 605 ? -28.519 -68.421 -5.325  1.00 26.32  ? 868  ASN A C   1 
ATOM   4484 O  O   . ASN A 1 605 ? -29.562 -68.138 -4.759  1.00 23.38  ? 868  ASN A O   1 
ATOM   4485 C  CB  . ASN A 1 605 ? -28.622 -70.707 -6.504  1.00 29.54  ? 868  ASN A CB  1 
ATOM   4486 C  CG  . ASN A 1 605 ? -29.124 -71.415 -7.751  1.00 35.45  ? 868  ASN A CG  1 
ATOM   4487 O  OD1 . ASN A 1 605 ? -29.785 -70.836 -8.616  1.00 41.78  ? 868  ASN A OD1 1 
ATOM   4488 N  ND2 . ASN A 1 605 ? -28.804 -72.681 -7.870  1.00 43.94  ? 868  ASN A ND2 1 
ATOM   4489 N  N   . GLN A 1 606 ? -27.327 -68.063 -4.837  1.00 24.17  ? 869  GLN A N   1 
ATOM   4490 C  CA  . GLN A 1 606 ? -27.200 -67.249 -3.607  1.00 23.90  ? 869  GLN A CA  1 
ATOM   4491 C  C   . GLN A 1 606 ? -27.868 -65.885 -3.817  1.00 23.61  ? 869  GLN A C   1 
ATOM   4492 O  O   . GLN A 1 606 ? -28.629 -65.426 -2.926  1.00 26.70  ? 869  GLN A O   1 
ATOM   4493 C  CB  . GLN A 1 606 ? -25.754 -67.002 -3.187  1.00 24.06  ? 869  GLN A CB  1 
ATOM   4494 C  CG  . GLN A 1 606 ? -25.666 -66.267 -1.848  1.00 29.33  ? 869  GLN A CG  1 
ATOM   4495 C  CD  . GLN A 1 606 ? -24.255 -65.951 -1.404  1.00 37.16  ? 869  GLN A CD  1 
ATOM   4496 O  OE1 . GLN A 1 606 ? -23.343 -65.872 -2.236  1.00 36.77  ? 869  GLN A OE1 1 
ATOM   4497 N  NE2 . GLN A 1 606 ? -24.081 -65.775 -0.098  1.00 31.36  ? 869  GLN A NE2 1 
ATOM   4498 N  N   . VAL A 1 607 ? -27.579 -65.217 -4.930  1.00 22.91  ? 870  VAL A N   1 
ATOM   4499 C  CA  . VAL A 1 607 ? -28.179 -63.887 -5.202  1.00 21.03  ? 870  VAL A CA  1 
ATOM   4500 C  C   . VAL A 1 607 ? -29.705 -64.052 -5.438  1.00 21.27  ? 870  VAL A C   1 
ATOM   4501 O  O   . VAL A 1 607 ? -30.469 -63.266 -4.882  1.00 20.48  ? 870  VAL A O   1 
ATOM   4502 C  CB  . VAL A 1 607 ? -27.466 -63.230 -6.385  1.00 23.35  ? 870  VAL A CB  1 
ATOM   4503 C  CG1 . VAL A 1 607 ? -28.179 -61.958 -6.802  1.00 21.79  ? 870  VAL A CG1 1 
ATOM   4504 C  CG2 . VAL A 1 607 ? -25.986 -62.992 -6.060  1.00 22.15  ? 870  VAL A CG2 1 
ATOM   4505 N  N   . ARG A 1 608 ? -30.138 -65.064 -6.195  1.00 21.27  ? 871  ARG A N   1 
ATOM   4506 C  CA  . ARG A 1 608 ? -31.595 -65.295 -6.432  1.00 24.14  ? 871  ARG A CA  1 
ATOM   4507 C  C   . ARG A 1 608 ? -32.333 -65.487 -5.099  1.00 24.48  ? 871  ARG A C   1 
ATOM   4508 O  O   . ARG A 1 608 ? -33.448 -64.927 -4.951  1.00 27.26  ? 871  ARG A O   1 
ATOM   4509 C  CB  . ARG A 1 608 ? -31.819 -66.496 -7.349  1.00 23.38  ? 871  ARG A CB  1 
ATOM   4510 C  CG  . ARG A 1 608 ? -31.431 -66.246 -8.793  1.00 22.19  ? 871  ARG A CG  1 
ATOM   4511 C  CD  . ARG A 1 608 ? -31.659 -67.520 -9.559  1.00 23.85  ? 871  ARG A CD  1 
ATOM   4512 N  NE  . ARG A 1 608 ? -31.572 -67.305 -10.978 1.00 25.26  ? 871  ARG A NE  1 
ATOM   4513 C  CZ  . ARG A 1 608 ? -31.462 -68.269 -11.856 1.00 28.07  ? 871  ARG A CZ  1 
ATOM   4514 N  NH1 . ARG A 1 608 ? -31.493 -69.524 -11.438 1.00 33.98  ? 871  ARG A NH1 1 
ATOM   4515 N  NH2 . ARG A 1 608 ? -31.327 -67.986 -13.133 1.00 27.09  ? 871  ARG A NH2 1 
ATOM   4516 N  N   . SER A 1 609 ? -31.746 -66.210 -4.160  1.00 24.16  ? 872  SER A N   1 
ATOM   4517 C  CA  . SER A 1 609 ? -32.350 -66.438 -2.826  1.00 25.91  ? 872  SER A CA  1 
ATOM   4518 C  C   . SER A 1 609 ? -32.451 -65.128 -2.051  1.00 26.00  ? 872  SER A C   1 
ATOM   4519 O  O   . SER A 1 609 ? -33.374 -64.988 -1.252  1.00 22.97  ? 872  SER A O   1 
ATOM   4520 C  CB  . SER A 1 609 ? -31.614 -67.487 -2.026  1.00 26.76  ? 872  SER A CB  1 
ATOM   4521 O  OG  . SER A 1 609 ? -31.581 -68.724 -2.725  1.00 26.07  ? 872  SER A OG  1 
ATOM   4522 N  N   . LEU A 1 610 ? -31.507 -64.205 -2.186  1.00 22.96  ? 873  LEU A N   1 
ATOM   4523 C  CA  . LEU A 1 610 ? -31.601 -62.911 -1.459  1.00 21.94  ? 873  LEU A CA  1 
ATOM   4524 C  C   . LEU A 1 610 ? -32.703 -62.038 -2.072  1.00 21.78  ? 873  LEU A C   1 
ATOM   4525 O  O   . LEU A 1 610 ? -33.410 -61.362 -1.331  1.00 23.25  ? 873  LEU A O   1 
ATOM   4526 C  CB  . LEU A 1 610 ? -30.223 -62.240 -1.517  1.00 22.84  ? 873  LEU A CB  1 
ATOM   4527 C  CG  . LEU A 1 610 ? -29.131 -62.907 -0.704  1.00 23.03  ? 873  LEU A CG  1 
ATOM   4528 C  CD1 . LEU A 1 610 ? -27.752 -62.330 -1.035  1.00 27.31  ? 873  LEU A CD1 1 
ATOM   4529 C  CD2 . LEU A 1 610 ? -29.408 -62.798 0.799   1.00 25.34  ? 873  LEU A CD2 1 
ATOM   4530 N  N   . ILE A 1 611 ? -32.812 -61.985 -3.397  1.00 24.08  ? 874  ILE A N   1 
ATOM   4531 C  CA  . ILE A 1 611 ? -33.783 -61.111 -4.107  1.00 23.67  ? 874  ILE A CA  1 
ATOM   4532 C  C   . ILE A 1 611 ? -35.185 -61.713 -3.921  1.00 27.76  ? 874  ILE A C   1 
ATOM   4533 O  O   . ILE A 1 611 ? -36.129 -60.945 -3.707  1.00 27.00  ? 874  ILE A O   1 
ATOM   4534 C  CB  . ILE A 1 611 ? -33.382 -60.944 -5.589  1.00 25.44  ? 874  ILE A CB  1 
ATOM   4535 C  CG1 . ILE A 1 611 ? -32.071 -60.171 -5.729  1.00 25.72  ? 874  ILE A CG1 1 
ATOM   4536 C  CG2 . ILE A 1 611 ? -34.484 -60.237 -6.374  1.00 26.88  ? 874  ILE A CG2 1 
ATOM   4537 C  CD1 . ILE A 1 611 ? -31.548 -60.070 -7.115  1.00 25.19  ? 874  ILE A CD1 1 
ATOM   4538 N  N   . GLY A 1 612 ? -35.288 -63.031 -3.938  1.00 24.85  ? 875  GLY A N   1 
ATOM   4539 C  CA  . GLY A 1 612 ? -36.524 -63.780 -3.609  1.00 31.02  ? 875  GLY A CA  1 
ATOM   4540 C  C   . GLY A 1 612 ? -37.169 -64.420 -4.825  1.00 30.06  ? 875  GLY A C   1 
ATOM   4541 O  O   . GLY A 1 612 ? -36.562 -64.536 -5.893  1.00 27.31  ? 875  GLY A O   1 
ATOM   4542 N  N   . ASN A 1 613 ? -38.454 -64.746 -4.719  1.00 34.23  ? 876  ASN A N   1 
ATOM   4543 C  CA  . ASN A 1 613 ? -39.184 -65.547 -5.735  1.00 32.51  ? 876  ASN A CA  1 
ATOM   4544 C  C   . ASN A 1 613 ? -39.648 -64.637 -6.887  1.00 35.69  ? 876  ASN A C   1 
ATOM   4545 O  O   . ASN A 1 613 ? -40.743 -64.088 -6.835  1.00 39.73  ? 876  ASN A O   1 
ATOM   4546 C  CB  . ASN A 1 613 ? -40.366 -66.237 -5.042  1.00 41.12  ? 876  ASN A CB  1 
ATOM   4547 C  CG  . ASN A 1 613 ? -40.987 -67.349 -5.859  1.00 46.45  ? 876  ASN A CG  1 
ATOM   4548 O  OD1 . ASN A 1 613 ? -40.439 -67.759 -6.870  1.00 42.56  ? 876  ASN A OD1 1 
ATOM   4549 N  ND2 . ASN A 1 613 ? -42.107 -67.884 -5.388  1.00 46.92  ? 876  ASN A ND2 1 
ATOM   4550 N  N   . GLU A 1 614 ? -38.883 -64.578 -7.954  1.00 27.57  ? 877  GLU A N   1 
ATOM   4551 C  CA  . GLU A 1 614 ? -39.030 -63.626 -9.066  1.00 24.24  ? 877  GLU A CA  1 
ATOM   4552 C  C   . GLU A 1 614 ? -38.875 -64.483 -10.319 1.00 23.81  ? 877  GLU A C   1 
ATOM   4553 O  O   . GLU A 1 614 ? -38.577 -65.706 -10.175 1.00 26.81  ? 877  GLU A O   1 
ATOM   4554 C  CB  . GLU A 1 614 ? -37.991 -62.497 -8.978  1.00 24.87  ? 877  GLU A CB  1 
ATOM   4555 C  CG  . GLU A 1 614 ? -38.181 -61.586 -7.786  1.00 26.62  ? 877  GLU A CG  1 
ATOM   4556 C  CD  . GLU A 1 614 ? -39.378 -60.622 -7.850  1.00 27.06  ? 877  GLU A CD  1 
ATOM   4557 O  OE1 . GLU A 1 614 ? -39.967 -60.427 -8.926  1.00 26.95  ? 877  GLU A OE1 1 
ATOM   4558 O  OE2 . GLU A 1 614 ? -39.625 -59.985 -6.842  1.00 27.99  ? 877  GLU A OE2 1 
ATOM   4559 N  N   . GLU A 1 615 ? -39.108 -63.910 -11.485 1.00 28.01  ? 878  GLU A N   1 
ATOM   4560 C  CA  . GLU A 1 615 ? -38.900 -64.638 -12.765 1.00 29.70  ? 878  GLU A CA  1 
ATOM   4561 C  C   . GLU A 1 615 ? -37.444 -64.384 -13.185 1.00 27.81  ? 878  GLU A C   1 
ATOM   4562 O  O   . GLU A 1 615 ? -37.136 -63.208 -13.453 1.00 29.36  ? 878  GLU A O   1 
ATOM   4563 C  CB  . GLU A 1 615 ? -39.816 -64.146 -13.889 1.00 36.23  ? 878  GLU A CB  1 
ATOM   4564 C  CG  . GLU A 1 615 ? -39.588 -64.945 -15.180 1.00 44.62  ? 878  GLU A CG  1 
ATOM   4565 C  CD  . GLU A 1 615 ? -40.385 -64.504 -16.410 1.00 58.25  ? 878  GLU A CD  1 
ATOM   4566 O  OE1 . GLU A 1 615 ? -41.427 -63.808 -16.247 1.00 53.22  ? 878  GLU A OE1 1 
ATOM   4567 O  OE2 . GLU A 1 615 ? -39.967 -64.858 -17.544 1.00 68.42  ? 878  GLU A OE2 1 
ATOM   4568 N  N   . TYR A 1 616 ? -36.670 -65.452 -13.330 1.00 28.62  ? 879  TYR A N   1 
ATOM   4569 C  CA  . TYR A 1 616 ? -35.242 -65.462 -13.749 1.00 31.44  ? 879  TYR A CA  1 
ATOM   4570 C  C   . TYR A 1 616 ? -35.078 -66.269 -15.032 1.00 35.01  ? 879  TYR A C   1 
ATOM   4571 O  O   . TYR A 1 616 ? -35.840 -67.196 -15.255 1.00 30.49  ? 879  TYR A O   1 
ATOM   4572 C  CB  . TYR A 1 616 ? -34.376 -66.057 -12.641 1.00 30.35  ? 879  TYR A CB  1 
ATOM   4573 C  CG  . TYR A 1 616 ? -34.451 -65.353 -11.309 1.00 26.96  ? 879  TYR A CG  1 
ATOM   4574 C  CD1 . TYR A 1 616 ? -33.696 -64.211 -11.032 1.00 25.02  ? 879  TYR A CD1 1 
ATOM   4575 C  CD2 . TYR A 1 616 ? -35.231 -65.873 -10.284 1.00 26.34  ? 879  TYR A CD2 1 
ATOM   4576 C  CE1 . TYR A 1 616 ? -33.763 -63.582 -9.786  1.00 28.38  ? 879  TYR A CE1 1 
ATOM   4577 C  CE2 . TYR A 1 616 ? -35.294 -65.263 -9.038  1.00 25.38  ? 879  TYR A CE2 1 
ATOM   4578 C  CZ  . TYR A 1 616 ? -34.556 -64.115 -8.779  1.00 27.18  ? 879  TYR A CZ  1 
ATOM   4579 O  OH  . TYR A 1 616 ? -34.616 -63.533 -7.529  1.00 28.88  ? 879  TYR A OH  1 
ATOM   4580 N  N   . THR A 1 617 ? -34.075 -65.907 -15.843 1.00 31.73  ? 880  THR A N   1 
ATOM   4581 C  CA  . THR A 1 617 ? -33.596 -66.670 -17.030 1.00 33.56  ? 880  THR A CA  1 
ATOM   4582 C  C   . THR A 1 617 ? -32.180 -67.187 -16.749 1.00 32.81  ? 880  THR A C   1 
ATOM   4583 O  O   . THR A 1 617 ? -31.398 -66.426 -16.154 1.00 28.41  ? 880  THR A O   1 
ATOM   4584 C  CB  . THR A 1 617 ? -33.564 -65.734 -18.236 1.00 34.90  ? 880  THR A CB  1 
ATOM   4585 O  OG1 . THR A 1 617 ? -34.859 -65.126 -18.260 1.00 32.57  ? 880  THR A OG1 1 
ATOM   4586 C  CG2 . THR A 1 617 ? -33.226 -66.427 -19.536 1.00 36.39  ? 880  THR A CG2 1 
ATOM   4587 N  N   . ASP A 1 618 ? -31.873 -68.423 -17.124 1.00 29.95  ? 881  ASP A N   1 
ATOM   4588 C  CA  . ASP A 1 618 ? -30.478 -68.945 -17.126 1.00 33.08  ? 881  ASP A CA  1 
ATOM   4589 C  C   . ASP A 1 618 ? -29.798 -68.554 -18.448 1.00 32.57  ? 881  ASP A C   1 
ATOM   4590 O  O   . ASP A 1 618 ? -30.077 -69.186 -19.479 1.00 27.15  ? 881  ASP A O   1 
ATOM   4591 C  CB  . ASP A 1 618 ? -30.502 -70.459 -16.908 1.00 37.62  ? 881  ASP A CB  1 
ATOM   4592 C  CG  . ASP A 1 618 ? -29.120 -71.101 -16.842 1.00 44.78  ? 881  ASP A CG  1 
ATOM   4593 O  OD1 . ASP A 1 618 ? -28.098 -70.354 -16.573 1.00 34.84  ? 881  ASP A OD1 1 
ATOM   4594 O  OD2 . ASP A 1 618 ? -29.072 -72.350 -17.035 1.00 43.34  ? 881  ASP A OD2 1 
ATOM   4595 N  N   . TYR A 1 619 ? -28.871 -67.585 -18.432 1.00 32.13  ? 882  TYR A N   1 
ATOM   4596 C  CA  . TYR A 1 619 ? -28.062 -67.235 -19.628 1.00 30.33  ? 882  TYR A CA  1 
ATOM   4597 C  C   . TYR A 1 619 ? -26.757 -68.045 -19.703 1.00 29.29  ? 882  TYR A C   1 
ATOM   4598 O  O   . TYR A 1 619 ? -26.064 -67.881 -20.696 1.00 29.99  ? 882  TYR A O   1 
ATOM   4599 C  CB  . TYR A 1 619 ? -27.747 -65.740 -19.617 1.00 30.13  ? 882  TYR A CB  1 
ATOM   4600 C  CG  . TYR A 1 619 ? -28.976 -64.896 -19.792 1.00 34.76  ? 882  TYR A CG  1 
ATOM   4601 C  CD1 . TYR A 1 619 ? -29.633 -64.848 -21.014 1.00 32.90  ? 882  TYR A CD1 1 
ATOM   4602 C  CD2 . TYR A 1 619 ? -29.508 -64.177 -18.732 1.00 28.45  ? 882  TYR A CD2 1 
ATOM   4603 C  CE1 . TYR A 1 619 ? -30.777 -64.076 -21.191 1.00 32.83  ? 882  TYR A CE1 1 
ATOM   4604 C  CE2 . TYR A 1 619 ? -30.660 -63.416 -18.893 1.00 31.71  ? 882  TYR A CE2 1 
ATOM   4605 C  CZ  . TYR A 1 619 ? -31.277 -63.336 -20.132 1.00 34.47  ? 882  TYR A CZ  1 
ATOM   4606 O  OH  . TYR A 1 619 ? -32.389 -62.550 -20.274 1.00 34.01  ? 882  TYR A OH  1 
ATOM   4607 N  N   . MET A 1 620 ? -26.400 -68.861 -18.712 1.00 31.45  ? 883  MET A N   1 
ATOM   4608 C  CA  . MET A 1 620 ? -25.088 -69.555 -18.716 1.00 29.83  ? 883  MET A CA  1 
ATOM   4609 C  C   . MET A 1 620 ? -24.927 -70.513 -19.920 1.00 34.89  ? 883  MET A C   1 
ATOM   4610 O  O   . MET A 1 620 ? -23.822 -70.543 -20.508 1.00 35.03  ? 883  MET A O   1 
ATOM   4611 C  CB  . MET A 1 620 ? -24.761 -70.228 -17.382 1.00 31.42  ? 883  MET A CB  1 
ATOM   4612 C  CG  . MET A 1 620 ? -24.862 -69.303 -16.155 1.00 31.52  ? 883  MET A CG  1 
ATOM   4613 S  SD  . MET A 1 620 ? -24.047 -67.663 -16.358 1.00 29.29  ? 883  MET A SD  1 
ATOM   4614 C  CE  . MET A 1 620 ? -22.345 -68.201 -16.532 1.00 28.05  ? 883  MET A CE  1 
ATOM   4615 N  N   . PRO A 1 621 ? -25.954 -71.276 -20.390 1.00 38.55  ? 884  PRO A N   1 
ATOM   4616 C  CA  . PRO A 1 621 ? -25.806 -72.125 -21.597 1.00 38.23  ? 884  PRO A CA  1 
ATOM   4617 C  C   . PRO A 1 621 ? -25.641 -71.428 -22.967 1.00 41.71  ? 884  PRO A C   1 
ATOM   4618 O  O   . PRO A 1 621 ? -25.446 -72.124 -23.951 1.00 43.65  ? 884  PRO A O   1 
ATOM   4619 C  CB  . PRO A 1 621 ? -27.106 -72.976 -21.624 1.00 39.32  ? 884  PRO A CB  1 
ATOM   4620 C  CG  . PRO A 1 621 ? -27.669 -72.910 -20.203 1.00 40.02  ? 884  PRO A CG  1 
ATOM   4621 C  CD  . PRO A 1 621 ? -27.248 -71.530 -19.710 1.00 41.46  ? 884  PRO A CD  1 
ATOM   4622 N  N   . SER A 1 622 ? -25.647 -70.087 -23.017 1.00 39.33  ? 885  SER A N   1 
ATOM   4623 C  CA  . SER A 1 622 ? -25.144 -69.275 -24.165 1.00 42.48  ? 885  SER A CA  1 
ATOM   4624 C  C   . SER A 1 622 ? -23.621 -69.458 -24.308 1.00 43.73  ? 885  SER A C   1 
ATOM   4625 O  O   . SER A 1 622 ? -23.072 -69.049 -25.363 1.00 44.27  ? 885  SER A O   1 
ATOM   4626 C  CB  . SER A 1 622 ? -25.494 -67.794 -24.029 1.00 43.58  ? 885  SER A CB  1 
ATOM   4627 O  OG  . SER A 1 622 ? -24.754 -67.149 -22.985 1.00 37.13  ? 885  SER A OG  1 
ATOM   4628 N  N   . MET A 1 623 ? -22.957 -70.002 -23.283 1.00 37.20  ? 886  MET A N   1 
ATOM   4629 C  CA  . MET A 1 623 ? -21.495 -70.270 -23.325 1.00 44.88  ? 886  MET A CA  1 
ATOM   4630 C  C   . MET A 1 623 ? -21.265 -71.768 -23.577 1.00 46.85  ? 886  MET A C   1 
ATOM   4631 O  O   . MET A 1 623 ? -21.920 -72.593 -22.891 1.00 38.88  ? 886  MET A O   1 
ATOM   4632 C  CB  . MET A 1 623 ? -20.819 -69.857 -22.009 1.00 46.86  ? 886  MET A CB  1 
ATOM   4633 C  CG  . MET A 1 623 ? -21.209 -68.480 -21.553 1.00 48.65  ? 886  MET A CG  1 
ATOM   4634 S  SD  . MET A 1 623 ? -20.356 -67.993 -20.029 1.00 43.63  ? 886  MET A SD  1 
ATOM   4635 C  CE  . MET A 1 623 ? -18.805 -67.494 -20.751 1.00 42.89  ? 886  MET A CE  1 
ATOM   4636 N  N   . LYS A 1 624 ? -20.305 -72.095 -24.446 1.00 52.29  ? 887  LYS A N   1 
ATOM   4637 C  CA  . LYS A 1 624 ? -19.951 -73.492 -24.826 1.00 55.43  ? 887  LYS A CA  1 
ATOM   4638 C  C   . LYS A 1 624 ? -19.876 -74.382 -23.569 1.00 52.27  ? 887  LYS A C   1 
ATOM   4639 O  O   . LYS A 1 624 ? -20.546 -75.441 -23.550 1.00 45.79  ? 887  LYS A O   1 
ATOM   4640 C  CB  . LYS A 1 624 ? -18.640 -73.497 -25.626 1.00 63.65  ? 887  LYS A CB  1 
ATOM   4641 C  CG  . LYS A 1 624 ? -18.455 -74.698 -26.556 1.00 71.98  ? 887  LYS A CG  1 
ATOM   4642 C  CD  . LYS A 1 624 ? -17.450 -74.478 -27.695 1.00 74.12  ? 887  LYS A CD  1 
ATOM   4643 C  CE  . LYS A 1 624 ? -16.148 -75.245 -27.526 1.00 80.12  ? 887  LYS A CE  1 
ATOM   4644 N  NZ  . LYS A 1 624 ? -15.345 -74.750 -26.381 1.00 79.13  ? 887  LYS A NZ  1 
ATOM   4645 N  N   . ARG A 1 625 ? -19.146 -73.963 -22.527 1.00 51.08  ? 888  ARG A N   1 
ATOM   4646 C  CA  . ARG A 1 625 ? -18.791 -74.848 -21.369 1.00 52.64  ? 888  ARG A CA  1 
ATOM   4647 C  C   . ARG A 1 625 ? -20.004 -75.189 -20.475 1.00 46.43  ? 888  ARG A C   1 
ATOM   4648 O  O   . ARG A 1 625 ? -19.871 -76.125 -19.700 1.00 42.15  ? 888  ARG A O   1 
ATOM   4649 C  CB  . ARG A 1 625 ? -17.675 -74.234 -20.514 1.00 51.77  ? 888  ARG A CB  1 
ATOM   4650 C  CG  . ARG A 1 625 ? -18.045 -72.950 -19.779 1.00 50.73  ? 888  ARG A CG  1 
ATOM   4651 C  CD  . ARG A 1 625 ? -16.971 -72.487 -18.785 1.00 50.22  ? 888  ARG A CD  1 
ATOM   4652 N  NE  . ARG A 1 625 ? -16.886 -73.388 -17.638 1.00 51.85  ? 888  ARG A NE  1 
ATOM   4653 C  CZ  . ARG A 1 625 ? -15.818 -73.568 -16.864 1.00 48.58  ? 888  ARG A CZ  1 
ATOM   4654 N  NH1 . ARG A 1 625 ? -14.688 -72.898 -17.073 1.00 57.48  ? 888  ARG A NH1 1 
ATOM   4655 N  NH2 . ARG A 1 625 ? -15.888 -74.422 -15.865 1.00 44.15  ? 888  ARG A NH2 1 
ATOM   4656 N  N   . PHE A 1 626 ? -21.111 -74.427 -20.499 1.00 44.83  ? 889  PHE A N   1 
ATOM   4657 C  CA  . PHE A 1 626 ? -22.343 -74.709 -19.694 1.00 49.13  ? 889  PHE A CA  1 
ATOM   4658 C  C   . PHE A 1 626 ? -23.442 -75.277 -20.610 1.00 55.31  ? 889  PHE A C   1 
ATOM   4659 O  O   . PHE A 1 626 ? -24.592 -75.525 -20.168 1.00 56.09  ? 889  PHE A O   1 
ATOM   4660 C  CB  . PHE A 1 626 ? -22.804 -73.450 -18.944 1.00 45.92  ? 889  PHE A CB  1 
ATOM   4661 C  CG  . PHE A 1 626 ? -21.742 -72.839 -18.057 1.00 46.83  ? 889  PHE A CG  1 
ATOM   4662 C  CD1 . PHE A 1 626 ? -21.266 -73.516 -16.939 1.00 48.15  ? 889  PHE A CD1 1 
ATOM   4663 C  CD2 . PHE A 1 626 ? -21.170 -71.617 -18.377 1.00 40.75  ? 889  PHE A CD2 1 
ATOM   4664 C  CE1 . PHE A 1 626 ? -20.251 -72.979 -16.153 1.00 50.19  ? 889  PHE A CE1 1 
ATOM   4665 C  CE2 . PHE A 1 626 ? -20.161 -71.071 -17.588 1.00 43.58  ? 889  PHE A CE2 1 
ATOM   4666 C  CZ  . PHE A 1 626 ? -19.706 -71.748 -16.469 1.00 40.65  ? 889  PHE A CZ  1 
ATOM   4667 N  N   . ARG A 1 627 ? -23.120 -75.468 -21.886 1.00 66.32  ? 890  ARG A N   1 
ATOM   4668 C  CA  . ARG A 1 627 ? -24.087 -75.961 -22.894 1.00 81.75  ? 890  ARG A CA  1 
ATOM   4669 C  C   . ARG A 1 627 ? -24.045 -77.498 -22.858 1.00 91.80  ? 890  ARG A C   1 
ATOM   4670 O  O   . ARG A 1 627 ? -23.787 -78.090 -23.920 1.00 109.71 ? 890  ARG A O   1 
ATOM   4671 C  CB  . ARG A 1 627 ? -23.757 -75.316 -24.246 1.00 80.80  ? 890  ARG A CB  1 
ATOM   4672 C  CG  . ARG A 1 627 ? -24.881 -75.396 -25.266 1.00 82.67  ? 890  ARG A CG  1 
ATOM   4673 C  CD  . ARG A 1 627 ? -24.603 -74.593 -26.520 1.00 84.92  ? 890  ARG A CD  1 
ATOM   4674 N  NE  . ARG A 1 627 ? -23.257 -74.799 -27.038 1.00 90.40  ? 890  ARG A NE  1 
ATOM   4675 C  CZ  . ARG A 1 627 ? -22.837 -75.846 -27.754 1.00 91.23  ? 890  ARG A CZ  1 
ATOM   4676 N  NH1 . ARG A 1 627 ? -23.650 -76.847 -28.056 1.00 96.15  ? 890  ARG A NH1 1 
ATOM   4677 N  NH2 . ARG A 1 627 ? -21.582 -75.896 -28.165 1.00 89.56  ? 890  ARG A NH2 1 
ATOM   4678 N  N   . ARG A 1 628 ? -24.277 -78.100 -21.675 1.00 92.73  ? 891  ARG A N   1 
ATOM   4679 C  CA  . ARG A 1 628 ? -24.256 -79.570 -21.405 1.00 95.84  ? 891  ARG A CA  1 
ATOM   4680 C  C   . ARG A 1 628 ? -22.810 -80.083 -21.328 1.00 94.59  ? 891  ARG A C   1 
ATOM   4681 O  O   . ARG A 1 628 ? -21.969 -79.966 -22.225 1.00 78.57  ? 891  ARG A O   1 
ATOM   4682 C  CB  . ARG A 1 628 ? -25.083 -80.328 -22.453 1.00 98.99  ? 891  ARG A CB  1 
ATOM   4683 C  CG  . ARG A 1 628 ? -26.574 -80.039 -22.365 1.00 103.27 ? 891  ARG A CG  1 
ATOM   4684 C  CD  . ARG A 1 628 ? -27.114 -80.239 -20.960 1.00 105.20 ? 891  ARG A CD  1 
ATOM   4685 N  NE  . ARG A 1 628 ? -26.541 -81.405 -20.293 1.00 103.12 ? 891  ARG A NE  1 
ATOM   4686 C  CZ  . ARG A 1 628 ? -26.933 -81.879 -19.114 1.00 106.84 ? 891  ARG A CZ  1 
ATOM   4687 N  NH1 . ARG A 1 628 ? -27.917 -81.303 -18.445 1.00 111.88 ? 891  ARG A NH1 1 
ATOM   4688 N  NH2 . ARG A 1 628 ? -26.339 -82.943 -18.605 1.00 110.16 ? 891  ARG A NH2 1 
HETATM 4689 ZN ZN  . ZN  B 2 .   ? -6.513  -55.213 -23.737 1.00 20.24  2 1001 ZN  A ZN  1 
HETATM 4690 ZN ZN  . ZN  C 2 .   ? -25.874 -14.420 -13.088 1.00 49.79  2 1002 ZN  A ZN  1 
HETATM 4691 O  O1  A MES D 3 .   ? -28.399 -57.543 -0.201  0.25 30.36  ? 1003 MES A O1  1 
HETATM 4692 O  O1  B MES D 3 .   ? -28.375 -57.780 0.184   0.25 594.89 ? 1003 MES A O1  1 
HETATM 4693 C  C2  A MES D 3 .   ? -27.993 -57.841 1.124   0.25 29.26  ? 1003 MES A C2  1 
HETATM 4694 C  C2  B MES D 3 .   ? -27.515 -58.091 1.269   0.25 602.61 ? 1003 MES A C2  1 
HETATM 4695 C  C3  A MES D 3 .   ? -26.553 -57.439 1.347   0.25 30.27  ? 1003 MES A C3  1 
HETATM 4696 C  C3  B MES D 3 .   ? -26.074 -57.814 0.920   0.25 603.70 ? 1003 MES A C3  1 
HETATM 4697 N  N4  A MES D 3 .   ? -25.666 -58.138 0.370   0.25 25.84  ? 1003 MES A N4  1 
HETATM 4698 N  N4  B MES D 3 .   ? -25.669 -58.603 -0.286  0.25 600.73 ? 1003 MES A N4  1 
HETATM 4699 C  C5  A MES D 3 .   ? -26.163 -57.925 -1.023  0.25 27.81  ? 1003 MES A C5  1 
HETATM 4700 C  C5  B MES D 3 .   ? -26.637 -58.347 -1.398  0.25 593.53 ? 1003 MES A C5  1 
HETATM 4701 C  C6  A MES D 3 .   ? -27.628 -58.291 -1.125  0.25 30.14  ? 1003 MES A C6  1 
HETATM 4702 C  C6  B MES D 3 .   ? -28.048 -58.596 -0.929  0.25 586.73 ? 1003 MES A C6  1 
HETATM 4703 C  C7  A MES D 3 .   ? -24.233 -57.701 0.500   0.25 24.49  ? 1003 MES A C7  1 
HETATM 4704 C  C7  B MES D 3 .   ? -24.265 -58.274 -0.703  0.25 598.78 ? 1003 MES A C7  1 
HETATM 4705 C  C8  A MES D 3 .   ? -23.309 -58.600 -0.291  0.25 22.74  ? 1003 MES A C8  1 
HETATM 4706 C  C8  B MES D 3 .   ? -23.238 -58.567 0.368   0.25 623.02 ? 1003 MES A C8  1 
HETATM 4707 S  S   A MES D 3 .   ? -21.588 -58.130 -0.185  0.25 22.23  ? 1003 MES A S   1 
HETATM 4708 S  S   B MES D 3 .   ? -21.593 -58.050 -0.071  0.25 646.19 ? 1003 MES A S   1 
HETATM 4709 O  O1S A MES D 3 .   ? -21.184 -58.428 1.166   0.25 20.98  ? 1003 MES A O1S 1 
HETATM 4710 O  O1S B MES D 3 .   ? -21.257 -58.770 -1.270  0.25 638.70 ? 1003 MES A O1S 1 
HETATM 4711 O  O2S A MES D 3 .   ? -20.951 -58.934 -1.187  0.25 22.49  ? 1003 MES A O2S 1 
HETATM 4712 O  O2S B MES D 3 .   ? -21.665 -56.629 -0.273  0.25 641.11 ? 1003 MES A O2S 1 
HETATM 4713 O  O3S A MES D 3 .   ? -21.532 -56.721 -0.466  0.25 22.47  ? 1003 MES A O3S 1 
HETATM 4714 O  O3S B MES D 3 .   ? -20.752 -58.404 1.040   0.25 652.20 ? 1003 MES A O3S 1 
HETATM 4715 S  S   . DMS E 4 .   ? -26.937 -61.884 -21.014 1.00 40.27  ? 1004 DMS A S   1 
HETATM 4716 O  O   . DMS E 4 .   ? -26.759 -62.574 -22.421 1.00 41.20  ? 1004 DMS A O   1 
HETATM 4717 C  C1  . DMS E 4 .   ? -28.137 -60.626 -21.232 1.00 39.26  ? 1004 DMS A C1  1 
HETATM 4718 C  C2  . DMS E 4 .   ? -25.474 -60.851 -20.930 1.00 40.98  ? 1004 DMS A C2  1 
HETATM 4719 S  S   . DMS F 4 .   ? -16.105 -69.258 -28.890 1.00 99.19  ? 1005 DMS A S   1 
HETATM 4720 O  O   . DMS F 4 .   ? -16.497 -67.797 -29.013 1.00 67.76  ? 1005 DMS A O   1 
HETATM 4721 C  C1  . DMS F 4 .   ? -17.088 -69.958 -27.581 1.00 83.67  ? 1005 DMS A C1  1 
HETATM 4722 C  C2  . DMS F 4 .   ? -14.515 -69.322 -28.094 1.00 91.08  ? 1005 DMS A C2  1 
HETATM 4723 P  P   . PO4 G 5 .   ? -4.063  -39.300 -23.838 1.00 50.60  ? 1006 PO4 A P   1 
HETATM 4724 O  O1  . PO4 G 5 .   ? -2.694  -40.108 -23.234 1.00 32.40  ? 1006 PO4 A O1  1 
HETATM 4725 O  O2  . PO4 G 5 .   ? -3.592  -37.869 -24.604 1.00 32.91  ? 1006 PO4 A O2  1 
HETATM 4726 O  O3  . PO4 G 5 .   ? -4.847  -40.224 -24.904 1.00 40.06  ? 1006 PO4 A O3  1 
HETATM 4727 O  O4  . PO4 G 5 .   ? -4.948  -38.953 -22.709 1.00 55.04  ? 1006 PO4 A O4  1 
HETATM 4728 P  P   . PO4 H 5 .   ? -17.871 -9.445  -28.712 1.00 91.24  ? 1007 PO4 A P   1 
HETATM 4729 O  O1  . PO4 H 5 .   ? -17.552 -9.969  -27.272 1.00 57.08  ? 1007 PO4 A O1  1 
HETATM 4730 O  O2  . PO4 H 5 .   ? -16.553 -9.154  -29.455 1.00 76.64  ? 1007 PO4 A O2  1 
HETATM 4731 O  O3  . PO4 H 5 .   ? -18.724 -10.516 -29.467 1.00 69.06  ? 1007 PO4 A O3  1 
HETATM 4732 O  O4  . PO4 H 5 .   ? -18.678 -8.111  -28.645 1.00 72.70  ? 1007 PO4 A O4  1 
HETATM 4733 C  C1  . PEG I 6 .   ? -16.488 -43.566 -41.156 1.00 65.87  ? 1008 PEG A C1  1 
HETATM 4734 O  O1  . PEG I 6 .   ? -17.872 -43.763 -40.936 1.00 59.00  ? 1008 PEG A O1  1 
HETATM 4735 C  C2  . PEG I 6 .   ? -16.058 -44.140 -42.449 1.00 68.86  ? 1008 PEG A C2  1 
HETATM 4736 O  O2  . PEG I 6 .   ? -16.625 -45.439 -42.577 1.00 74.44  ? 1008 PEG A O2  1 
HETATM 4737 C  C3  . PEG I 6 .   ? -16.476 -45.999 -43.878 1.00 70.77  ? 1008 PEG A C3  1 
HETATM 4738 C  C4  . PEG I 6 .   ? -15.213 -46.801 -43.948 1.00 74.18  ? 1008 PEG A C4  1 
HETATM 4739 O  O4  . PEG I 6 .   ? -15.441 -48.130 -44.388 1.00 67.87  ? 1008 PEG A O4  1 
HETATM 4740 CL CL  . CL  J 7 .   ? 4.158   -48.842 -29.752 1.00 36.51  ? 1009 CL  A CL  1 
HETATM 4741 C  C10 . JMM K 8 .   ? -6.821  -74.572 -14.829 0.46 61.81  ? 1010 JMM A C10 1 
HETATM 4742 C  C13 . JMM K 8 .   ? -8.374  -75.173 -17.169 0.46 60.95  ? 1010 JMM A C13 1 
HETATM 4743 C  C17 . JMM K 8 .   ? -7.231  -75.167 -11.571 0.46 63.48  ? 1010 JMM A C17 1 
HETATM 4744 C  C01 . JMM K 8 .   ? -10.020 -72.472 -20.165 0.46 57.24  ? 1010 JMM A C01 1 
HETATM 4745 C  C02 . JMM K 8 .   ? -9.567  -72.930 -18.911 0.46 56.16  ? 1010 JMM A C02 1 
HETATM 4746 C  C03 . JMM K 8 .   ? -8.218  -72.845 -18.938 0.46 59.29  ? 1010 JMM A C03 1 
HETATM 4747 O  O04 . JMM K 8 .   ? -7.810  -72.354 -20.146 0.46 57.48  ? 1010 JMM A O04 1 
HETATM 4748 C  C05 . JMM K 8 .   ? -8.946  -72.138 -20.869 0.46 57.46  ? 1010 JMM A C05 1 
HETATM 4749 C  C06 . JMM K 8 .   ? -7.117  -73.164 -17.992 0.46 61.43  ? 1010 JMM A C06 1 
HETATM 4750 O  O07 . JMM K 8 .   ? -6.106  -72.472 -17.985 0.46 62.52  ? 1010 JMM A O07 1 
HETATM 4751 N  N08 . JMM K 8 .   ? -7.259  -74.230 -17.190 0.46 62.00  ? 1010 JMM A N08 1 
HETATM 4752 C  C09 . JMM K 8 .   ? -6.252  -74.657 -16.224 0.46 62.42  ? 1010 JMM A C09 1 
HETATM 4753 N  N11 . JMM K 8 .   ? -8.087  -75.313 -14.729 0.46 60.82  ? 1010 JMM A N11 1 
HETATM 4754 C  C12 . JMM K 8 .   ? -9.056  -75.127 -15.821 0.46 61.17  ? 1010 JMM A C12 1 
HETATM 4755 C  C14 . JMM K 8 .   ? -8.340  -76.124 -13.686 0.46 62.26  ? 1010 JMM A C14 1 
HETATM 4756 O  O15 . JMM K 8 .   ? -9.386  -76.731 -13.596 0.46 61.84  ? 1010 JMM A O15 1 
HETATM 4757 C  C16 . JMM K 8 .   ? -7.287  -76.258 -12.608 0.46 63.69  ? 1010 JMM A C16 1 
HETATM 4758 C  C18 . JMM K 8 .   ? -7.781  -76.490 -11.204 0.46 63.33  ? 1010 JMM A C18 1 
HETATM 4759 O  O   . HOH L 9 .   ? -13.746 -49.203 -29.621 0.50 26.73  ? 1101 HOH A O   1 
HETATM 4760 O  O   . HOH L 9 .   ? 9.078   -17.700 -40.696 1.00 58.21  ? 1102 HOH A O   1 
HETATM 4761 O  O   . HOH L 9 .   ? -10.225 -74.985 -8.068  1.00 61.11  ? 1103 HOH A O   1 
HETATM 4762 O  O   . HOH L 9 .   ? -11.511 -11.846 -8.984  1.00 51.27  ? 1104 HOH A O   1 
HETATM 4763 O  O   . HOH L 9 .   ? -12.985 -21.736 -41.402 1.00 46.06  ? 1105 HOH A O   1 
HETATM 4764 O  O   . HOH L 9 .   ? -13.626 -74.289 -15.322 0.46 33.47  ? 1106 HOH A O   1 
HETATM 4765 O  O   . HOH L 9 .   ? -7.740  -49.033 0.636   1.00 47.48  ? 1107 HOH A O   1 
HETATM 4766 O  O   . HOH L 9 .   ? -29.413 -55.815 -36.349 1.00 49.38  ? 1108 HOH A O   1 
HETATM 4767 O  O   . HOH L 9 .   ? -15.321 -22.097 -18.933 0.50 39.04  ? 1109 HOH A O   1 
HETATM 4768 O  O   . HOH L 9 .   ? -5.335  -58.431 -29.758 1.00 37.33  ? 1110 HOH A O   1 
HETATM 4769 O  O   . HOH L 9 .   ? -33.653 -47.545 -4.445  1.00 32.05  ? 1111 HOH A O   1 
HETATM 4770 O  O   . HOH L 9 .   ? -32.657 -51.977 -27.204 1.00 42.58  ? 1112 HOH A O   1 
HETATM 4771 O  O   . HOH L 9 .   ? -20.023 -66.134 -37.674 1.00 57.74  ? 1113 HOH A O   1 
HETATM 4772 O  O   . HOH L 9 .   ? -32.178 -70.835 -8.973  1.00 49.35  ? 1114 HOH A O   1 
HETATM 4773 O  O   . HOH L 9 .   ? -34.595 -20.243 -23.729 1.00 49.22  ? 1115 HOH A O   1 
HETATM 4774 O  O   . HOH L 9 .   ? -21.260 -41.466 -35.497 1.00 48.28  ? 1116 HOH A O   1 
HETATM 4775 O  O   . HOH L 9 .   ? -27.298 -9.042  -30.338 1.00 53.37  ? 1117 HOH A O   1 
HETATM 4776 O  O   . HOH L 9 .   ? -39.380 -63.862 -19.740 1.00 63.37  ? 1118 HOH A O   1 
HETATM 4777 O  O   . HOH L 9 .   ? 1.190   -21.298 -45.354 1.00 46.36  ? 1119 HOH A O   1 
HETATM 4778 O  O   . HOH L 9 .   ? -13.481 -12.875 -27.237 1.00 40.55  ? 1120 HOH A O   1 
HETATM 4779 O  O   . HOH L 9 .   ? -17.082 -34.739 -41.958 1.00 56.95  ? 1121 HOH A O   1 
HETATM 4780 O  O   . HOH L 9 .   ? -25.056 -20.567 -8.018  1.00 58.44  ? 1122 HOH A O   1 
HETATM 4781 O  O   . HOH L 9 .   ? -22.580 -53.286 -46.640 1.00 45.04  ? 1123 HOH A O   1 
HETATM 4782 O  O   . HOH L 9 .   ? -24.584 -13.955 -4.958  1.00 52.99  ? 1124 HOH A O   1 
HETATM 4783 O  O   . HOH L 9 .   ? -23.470 -46.245 -36.834 1.00 56.96  ? 1125 HOH A O   1 
HETATM 4784 O  O   . HOH L 9 .   ? -7.667  -42.731 -42.817 1.00 50.34  ? 1126 HOH A O   1 
HETATM 4785 O  O   . HOH L 9 .   ? 4.742   -16.455 -21.560 1.00 54.85  ? 1127 HOH A O   1 
HETATM 4786 O  O   . HOH L 9 .   ? -23.181 -64.749 -38.833 1.00 45.95  ? 1128 HOH A O   1 
HETATM 4787 O  O   . HOH L 9 .   ? -19.737 -9.696  -32.986 1.00 51.47  ? 1129 HOH A O   1 
HETATM 4788 O  O   . HOH L 9 .   ? -16.269 -66.732 -20.761 1.00 46.29  ? 1130 HOH A O   1 
HETATM 4789 O  O   . HOH L 9 .   ? 10.434  -38.732 -29.724 1.00 47.99  ? 1131 HOH A O   1 
HETATM 4790 O  O   . HOH L 9 .   ? 5.880   -44.698 -35.891 1.00 46.36  ? 1132 HOH A O   1 
HETATM 4791 O  O   . HOH L 9 .   ? -4.374  -54.235 -11.727 1.00 47.05  ? 1133 HOH A O   1 
HETATM 4792 O  O   . HOH L 9 .   ? -40.469 -57.631 -6.398  1.00 40.85  ? 1134 HOH A O   1 
HETATM 4793 O  O   . HOH L 9 .   ? -32.414 -60.388 -18.935 1.00 40.83  ? 1135 HOH A O   1 
HETATM 4794 O  O   . HOH L 9 .   ? -29.972 -50.391 -27.062 1.00 40.99  ? 1136 HOH A O   1 
HETATM 4795 O  O   . HOH L 9 .   ? -22.012 -9.927  -9.344  1.00 55.10  ? 1137 HOH A O   1 
HETATM 4796 O  O   . HOH L 9 .   ? -38.308 -67.577 -8.433  1.00 35.83  ? 1138 HOH A O   1 
HETATM 4797 O  O   . HOH L 9 .   ? -6.852  -20.272 -26.902 1.00 38.63  ? 1139 HOH A O   1 
HETATM 4798 O  O   . HOH L 9 .   ? -40.246 -61.141 -11.384 1.00 25.40  ? 1140 HOH A O   1 
HETATM 4799 O  O   . HOH L 9 .   ? -29.273 -63.473 -34.316 1.00 57.55  ? 1141 HOH A O   1 
HETATM 4800 O  O   . HOH L 9 .   ? 6.508   -34.885 -43.733 1.00 44.37  ? 1142 HOH A O   1 
HETATM 4801 O  O   . HOH L 9 .   ? -24.156 -69.471 -27.670 1.00 38.18  ? 1143 HOH A O   1 
HETATM 4802 O  O   . HOH L 9 .   ? -4.318  -53.646 -28.041 1.00 25.62  ? 1144 HOH A O   1 
HETATM 4803 O  O   . HOH L 9 .   ? 1.474   -32.303 -38.857 1.00 27.42  ? 1145 HOH A O   1 
HETATM 4804 O  O   . HOH L 9 .   ? -4.026  -57.380 -9.852  1.00 32.42  ? 1146 HOH A O   1 
HETATM 4805 O  O   . HOH L 9 .   ? -26.431 -30.635 -23.253 1.00 45.95  ? 1147 HOH A O   1 
HETATM 4806 O  O   . HOH L 9 .   ? 0.156   -32.819 -27.872 1.00 25.33  ? 1148 HOH A O   1 
HETATM 4807 O  O   . HOH L 9 .   ? -27.215 -65.354 -40.007 1.00 49.02  ? 1149 HOH A O   1 
HETATM 4808 O  O   . HOH L 9 .   ? -35.856 -57.143 -30.842 1.00 57.86  ? 1150 HOH A O   1 
HETATM 4809 O  O   . HOH L 9 .   ? -34.515 -59.419 -22.923 1.00 52.77  ? 1151 HOH A O   1 
HETATM 4810 O  O   . HOH L 9 .   ? -16.677 -32.090 -18.089 1.00 49.08  ? 1152 HOH A O   1 
HETATM 4811 O  O   . HOH L 9 .   ? -14.781 -17.186 -36.116 1.00 39.72  ? 1153 HOH A O   1 
HETATM 4812 O  O   . HOH L 9 .   ? -31.789 -57.315 -21.765 1.00 31.05  ? 1154 HOH A O   1 
HETATM 4813 O  O   . HOH L 9 .   ? -17.958 -62.123 -2.917  1.00 21.37  ? 1155 HOH A O   1 
HETATM 4814 O  O   . HOH L 9 .   ? -20.687 -19.329 -38.754 1.00 55.25  ? 1156 HOH A O   1 
HETATM 4815 O  O   . HOH L 9 .   ? -28.435 -49.842 0.145   1.00 29.45  ? 1157 HOH A O   1 
HETATM 4816 O  O   . HOH L 9 .   ? 11.326  -34.413 -33.154 1.00 37.70  ? 1158 HOH A O   1 
HETATM 4817 O  O   . HOH L 9 .   ? -15.165 -54.318 -39.681 1.00 40.30  ? 1159 HOH A O   1 
HETATM 4818 O  O   . HOH L 9 .   ? -32.753 -63.391 -15.160 1.00 25.99  ? 1160 HOH A O   1 
HETATM 4819 O  O   . HOH L 9 .   ? -22.606 -65.804 -23.763 1.00 38.64  ? 1161 HOH A O   1 
HETATM 4820 O  O   . HOH L 9 .   ? 2.982   -51.299 -26.874 1.00 31.76  ? 1162 HOH A O   1 
HETATM 4821 O  O   . HOH L 9 .   ? -30.974 -73.678 -18.325 1.00 58.00  ? 1163 HOH A O   1 
HETATM 4822 O  O   . HOH L 9 .   ? -42.409 -62.984 -18.572 1.00 56.33  ? 1164 HOH A O   1 
HETATM 4823 O  O   . HOH L 9 .   ? -36.835 -50.201 -5.359  1.00 35.00  ? 1165 HOH A O   1 
HETATM 4824 O  O   . HOH L 9 .   ? -14.112 -44.775 -3.766  1.00 65.22  ? 1166 HOH A O   1 
HETATM 4825 O  O   . HOH L 9 .   ? -4.953  -15.456 -28.209 1.00 43.26  ? 1167 HOH A O   1 
HETATM 4826 O  O   . HOH L 9 .   ? -26.576 -25.473 -33.232 1.00 29.90  ? 1168 HOH A O   1 
HETATM 4827 O  O   . HOH L 9 .   ? -8.791  -63.922 -30.860 1.00 46.34  ? 1169 HOH A O   1 
HETATM 4828 O  O   . HOH L 9 .   ? 5.567   -30.023 -21.633 1.00 31.28  ? 1170 HOH A O   1 
HETATM 4829 O  O   . HOH L 9 .   ? -11.556 -47.140 -43.335 1.00 53.29  ? 1171 HOH A O   1 
HETATM 4830 O  O   . HOH L 9 .   ? -0.614  -11.042 -30.018 1.00 51.28  ? 1172 HOH A O   1 
HETATM 4831 O  O   . HOH L 9 .   ? -42.289 -62.934 -4.984  1.00 41.08  ? 1173 HOH A O   1 
HETATM 4832 O  O   . HOH L 9 .   ? -3.787  -61.526 -15.491 1.00 27.18  ? 1174 HOH A O   1 
HETATM 4833 O  O   . HOH L 9 .   ? -35.027 -50.067 -12.894 1.00 40.67  ? 1175 HOH A O   1 
HETATM 4834 O  O   . HOH L 9 .   ? -20.987 -47.092 -10.111 1.00 48.86  ? 1176 HOH A O   1 
HETATM 4835 O  O   . HOH L 9 .   ? -17.627 -61.880 -44.837 1.00 52.30  ? 1177 HOH A O   1 
HETATM 4836 O  O   . HOH L 9 .   ? 0.056   -31.134 -23.053 1.00 30.28  ? 1178 HOH A O   1 
HETATM 4837 O  O   . HOH L 9 .   ? -10.102 -60.828 -42.216 1.00 57.90  ? 1179 HOH A O   1 
HETATM 4838 O  O   . HOH L 9 .   ? 0.179   -64.646 -19.294 1.00 37.84  ? 1180 HOH A O   1 
HETATM 4839 O  O   . HOH L 9 .   ? -14.898 -34.746 -28.971 1.00 21.48  ? 1181 HOH A O   1 
HETATM 4840 O  O   . HOH L 9 .   ? -20.796 -64.064 -43.494 1.00 55.02  ? 1182 HOH A O   1 
HETATM 4841 O  O   . HOH L 9 .   ? -10.939 -62.252 -18.807 1.00 17.35  ? 1183 HOH A O   1 
HETATM 4842 O  O   . HOH L 9 .   ? -5.420  -60.227 -0.783  1.00 34.58  ? 1184 HOH A O   1 
HETATM 4843 O  O   . HOH L 9 .   ? 10.076  -25.556 -32.526 1.00 48.94  ? 1185 HOH A O   1 
HETATM 4844 O  O   . HOH L 9 .   ? -2.464  -55.457 -31.263 1.00 47.60  ? 1186 HOH A O   1 
HETATM 4845 O  O   . HOH L 9 .   ? 6.210   -31.323 -19.296 1.00 38.33  ? 1187 HOH A O   1 
HETATM 4846 O  O   . HOH L 9 .   ? -22.457 -50.999 -9.139  1.00 23.91  ? 1188 HOH A O   1 
HETATM 4847 O  O   . HOH L 9 .   ? -5.811  -59.143 -12.213 1.00 35.83  ? 1189 HOH A O   1 
HETATM 4848 O  O   . HOH L 9 .   ? -28.611 -69.593 -14.032 1.00 43.41  ? 1190 HOH A O   1 
HETATM 4849 O  O   . HOH L 9 .   ? 10.881  -40.760 -37.634 1.00 51.65  ? 1191 HOH A O   1 
HETATM 4850 O  O   . HOH L 9 .   ? -7.346  -47.210 -18.093 1.00 28.63  ? 1192 HOH A O   1 
HETATM 4851 O  O   . HOH L 9 .   ? -38.781 -60.805 -4.232  1.00 33.38  ? 1193 HOH A O   1 
HETATM 4852 O  O   . HOH L 9 .   ? 4.298   -26.566 -29.461 1.00 37.83  ? 1194 HOH A O   1 
HETATM 4853 O  O   . HOH L 9 .   ? 2.467   -44.214 -41.409 1.00 46.10  ? 1195 HOH A O   1 
HETATM 4854 O  O   . HOH L 9 .   ? -1.455  -41.509 -21.275 1.00 50.54  ? 1196 HOH A O   1 
HETATM 4855 O  O   . HOH L 9 .   ? -28.895 -45.665 2.625   1.00 39.86  ? 1197 HOH A O   1 
HETATM 4856 O  O   . HOH L 9 .   ? -9.748  -64.125 -33.184 1.00 50.33  ? 1198 HOH A O   1 
HETATM 4857 O  O   . HOH L 9 .   ? -8.359  -64.756 -6.987  1.00 30.44  ? 1199 HOH A O   1 
HETATM 4858 O  O   . HOH L 9 .   ? 7.834   -42.867 -36.347 1.00 46.22  ? 1200 HOH A O   1 
HETATM 4859 O  O   . HOH L 9 .   ? -22.951 -27.253 -24.524 1.00 40.34  ? 1201 HOH A O   1 
HETATM 4860 O  O   . HOH L 9 .   ? 4.916   -36.627 -23.577 0.50 29.59  ? 1202 HOH A O   1 
HETATM 4861 O  O   . HOH L 9 .   ? -9.064  -58.961 -13.329 1.00 22.20  ? 1203 HOH A O   1 
HETATM 4862 O  O   . HOH L 9 .   ? -9.037  -39.803 -39.746 1.00 49.79  ? 1204 HOH A O   1 
HETATM 4863 O  O   . HOH L 9 .   ? -29.657 -33.401 -28.568 1.00 59.26  ? 1205 HOH A O   1 
HETATM 4864 O  O   . HOH L 9 .   ? -5.242  -48.570 -28.691 1.00 29.59  ? 1206 HOH A O   1 
HETATM 4865 O  O   . HOH L 9 .   ? 5.910   -40.337 -20.161 1.00 57.40  ? 1207 HOH A O   1 
HETATM 4866 O  O   . HOH L 9 .   ? -19.549 -27.337 -40.087 1.00 31.22  ? 1208 HOH A O   1 
HETATM 4867 O  O   . HOH L 9 .   ? -14.653 -64.020 -0.476  1.00 24.11  ? 1209 HOH A O   1 
HETATM 4868 O  O   . HOH L 9 .   ? -21.311 -49.358 -34.888 1.00 38.34  ? 1210 HOH A O   1 
HETATM 4869 O  O   . HOH L 9 .   ? 10.452  -29.748 -34.350 1.00 40.70  ? 1211 HOH A O   1 
HETATM 4870 O  O   . HOH L 9 .   ? -20.695 -29.064 -24.926 1.00 43.67  ? 1212 HOH A O   1 
HETATM 4871 O  O   . HOH L 9 .   ? -38.841 -57.110 -20.488 1.00 38.68  ? 1213 HOH A O   1 
HETATM 4872 O  O   . HOH L 9 .   ? -22.256 -74.230 -11.692 1.00 29.89  ? 1214 HOH A O   1 
HETATM 4873 O  O   . HOH L 9 .   ? -38.632 -55.000 -18.962 1.00 35.31  ? 1215 HOH A O   1 
HETATM 4874 O  O   . HOH L 9 .   ? -9.363  -21.341 -26.949 1.00 34.40  ? 1216 HOH A O   1 
HETATM 4875 O  O   . HOH L 9 .   ? -2.591  -57.907 -27.460 1.00 23.82  ? 1217 HOH A O   1 
HETATM 4876 O  O   . HOH L 9 .   ? -19.286 -20.545 -40.516 1.00 42.13  ? 1218 HOH A O   1 
HETATM 4877 O  O   . HOH L 9 .   ? 5.829   -32.712 -37.675 1.00 37.77  ? 1219 HOH A O   1 
HETATM 4878 O  O   . HOH L 9 .   ? -34.729 -62.749 0.643   1.00 22.66  ? 1220 HOH A O   1 
HETATM 4879 O  O   . HOH L 9 .   ? -3.242  -20.151 -23.414 1.00 37.56  ? 1221 HOH A O   1 
HETATM 4880 O  O   . HOH L 9 .   ? -3.009  -55.093 -18.041 1.00 24.46  ? 1222 HOH A O   1 
HETATM 4881 O  O   . HOH L 9 .   ? -26.514 -71.304 -3.585  1.00 35.93  ? 1223 HOH A O   1 
HETATM 4882 O  O   . HOH L 9 .   ? -27.424 -52.330 -41.924 1.00 51.65  ? 1224 HOH A O   1 
HETATM 4883 O  O   . HOH L 9 .   ? -13.000 -53.417 -40.813 1.00 46.73  ? 1225 HOH A O   1 
HETATM 4884 O  O   . HOH L 9 .   ? -10.959 -48.191 -39.081 1.00 26.87  ? 1226 HOH A O   1 
HETATM 4885 O  O   . HOH L 9 .   ? -17.792 -65.863 -36.230 1.00 44.74  ? 1227 HOH A O   1 
HETATM 4886 O  O   . HOH L 9 .   ? -4.805  -34.212 -20.764 1.00 50.68  ? 1228 HOH A O   1 
HETATM 4887 O  O   . HOH L 9 .   ? -27.125 -56.993 -39.931 1.00 45.88  ? 1229 HOH A O   1 
HETATM 4888 O  O   . HOH L 9 .   ? -27.943 -18.157 -34.924 1.00 50.64  ? 1230 HOH A O   1 
HETATM 4889 O  O   . HOH L 9 .   ? -33.620 -57.384 -19.579 1.00 38.88  ? 1231 HOH A O   1 
HETATM 4890 O  O   . HOH L 9 .   ? -7.263  -49.724 -6.651  1.00 50.61  ? 1232 HOH A O   1 
HETATM 4891 O  O   . HOH L 9 .   ? -18.767 -65.160 -7.137  1.00 19.60  ? 1233 HOH A O   1 
HETATM 4892 O  O   . HOH L 9 .   ? 7.846   -21.941 -24.630 1.00 44.39  ? 1234 HOH A O   1 
HETATM 4893 O  O   . HOH L 9 .   ? 7.290   -49.588 -30.600 1.00 47.38  ? 1235 HOH A O   1 
HETATM 4894 O  O   . HOH L 9 .   ? -29.133 -17.496 -20.860 1.00 58.05  ? 1236 HOH A O   1 
HETATM 4895 O  O   . HOH L 9 .   ? -39.464 -55.258 -6.290  1.00 37.48  ? 1237 HOH A O   1 
HETATM 4896 O  O   . HOH L 9 .   ? -27.866 -47.104 -0.057  1.00 39.93  ? 1238 HOH A O   1 
HETATM 4897 O  O   . HOH L 9 .   ? -39.955 -24.097 -26.513 1.00 43.46  ? 1239 HOH A O   1 
HETATM 4898 O  O   . HOH L 9 .   ? 4.082   -28.698 -44.309 1.00 38.97  ? 1240 HOH A O   1 
HETATM 4899 O  O   . HOH L 9 .   ? -3.659  -54.739 -36.158 1.00 59.94  ? 1241 HOH A O   1 
HETATM 4900 O  O   . HOH L 9 .   ? -19.439 -17.148 -10.885 1.00 46.47  ? 1242 HOH A O   1 
HETATM 4901 O  O   . HOH L 9 .   ? -21.677 -66.060 -4.487  1.00 37.02  ? 1243 HOH A O   1 
HETATM 4902 O  O   . HOH L 9 .   ? -4.119  -22.997 -25.221 1.00 38.07  ? 1244 HOH A O   1 
HETATM 4903 O  O   . HOH L 9 .   ? 2.719   -39.504 -26.935 1.00 29.44  ? 1245 HOH A O   1 
HETATM 4904 O  O   . HOH L 9 .   ? -12.528 -58.107 -0.000  0.50 19.87  ? 1246 HOH A O   1 
HETATM 4905 O  O   . HOH L 9 .   ? -17.013 -51.890 -15.466 1.00 18.39  ? 1247 HOH A O   1 
HETATM 4906 O  O   . HOH L 9 .   ? -10.404 -39.128 -21.815 1.00 52.61  ? 1248 HOH A O   1 
HETATM 4907 O  O   . HOH L 9 .   ? -0.050  -55.179 -33.303 1.00 60.38  ? 1249 HOH A O   1 
HETATM 4908 O  O   . HOH L 9 .   ? -38.382 -60.842 -14.273 1.00 29.93  ? 1250 HOH A O   1 
HETATM 4909 O  O   . HOH L 9 .   ? -18.239 -75.876 -16.299 1.00 56.09  ? 1251 HOH A O   1 
HETATM 4910 O  O   . HOH L 9 .   ? -41.169 -58.107 -9.934  0.50 29.98  ? 1252 HOH A O   1 
HETATM 4911 O  O   . HOH L 9 .   ? 8.274   -44.980 -29.360 1.00 62.76  ? 1253 HOH A O   1 
HETATM 4912 O  O   . HOH L 9 .   ? -32.529 -48.885 -19.012 1.00 42.70  ? 1254 HOH A O   1 
HETATM 4913 O  O   . HOH L 9 .   ? -23.036 -33.478 -36.751 1.00 33.11  ? 1255 HOH A O   1 
HETATM 4914 O  O   . HOH L 9 .   ? -35.412 -66.826 -0.666  0.50 23.05  ? 1256 HOH A O   1 
HETATM 4915 O  O   . HOH L 9 .   ? -17.587 -30.719 -41.575 1.00 52.22  ? 1257 HOH A O   1 
HETATM 4916 O  O   . HOH L 9 .   ? -13.885 -49.583 -32.433 0.50 25.62  ? 1258 HOH A O   1 
HETATM 4917 O  O   . HOH L 9 .   ? 2.790   -64.547 -20.784 1.00 22.20  ? 1259 HOH A O   1 
HETATM 4918 O  O   . HOH L 9 .   ? -21.989 -31.210 -39.638 1.00 43.39  ? 1260 HOH A O   1 
HETATM 4919 O  O   . HOH L 9 .   ? -8.992  -26.303 -44.604 1.00 33.81  ? 1261 HOH A O   1 
HETATM 4920 O  O   . HOH L 9 .   ? -36.259 -58.201 -20.813 1.00 43.72  ? 1262 HOH A O   1 
HETATM 4921 O  O   . HOH L 9 .   ? 10.389  -26.850 -29.098 1.00 41.97  ? 1263 HOH A O   1 
HETATM 4922 O  O   . HOH L 9 .   ? -12.842 -42.472 -38.846 1.00 36.01  ? 1264 HOH A O   1 
HETATM 4923 O  O   . HOH L 9 .   ? -15.396 -65.839 -33.841 1.00 43.51  ? 1265 HOH A O   1 
HETATM 4924 O  O   . HOH L 9 .   ? -14.082 -52.183 -5.894  1.00 26.04  ? 1266 HOH A O   1 
HETATM 4925 O  O   . HOH L 9 .   ? -42.560 -61.630 -14.845 1.00 38.80  ? 1267 HOH A O   1 
HETATM 4926 O  O   . HOH L 9 .   ? -11.360 -41.098 -20.022 1.00 48.35  ? 1268 HOH A O   1 
HETATM 4927 O  O   . HOH L 9 .   ? 0.475   -23.454 -17.184 1.00 56.47  ? 1269 HOH A O   1 
HETATM 4928 O  O   . HOH L 9 .   ? 8.805   -24.018 -36.130 1.00 54.66  ? 1270 HOH A O   1 
HETATM 4929 O  O   . HOH L 9 .   ? -8.909  -70.936 -14.721 1.00 34.31  ? 1271 HOH A O   1 
HETATM 4930 O  O   . HOH L 9 .   ? -30.328 -56.796 -34.328 1.00 36.55  ? 1272 HOH A O   1 
HETATM 4931 O  O   . HOH L 9 .   ? -27.900 -22.913 -26.460 1.00 28.72  ? 1273 HOH A O   1 
HETATM 4932 O  O   . HOH L 9 .   ? -14.698 -68.519 -19.749 1.00 43.71  ? 1274 HOH A O   1 
HETATM 4933 O  O   . HOH L 9 .   ? 8.508   -40.388 -31.702 1.00 48.84  ? 1275 HOH A O   1 
HETATM 4934 O  O   . HOH L 9 .   ? -4.335  -65.364 -15.065 1.00 33.64  ? 1276 HOH A O   1 
HETATM 4935 O  O   . HOH L 9 .   ? -12.301 -36.876 -39.607 1.00 29.20  ? 1277 HOH A O   1 
HETATM 4936 O  O   . HOH L 9 .   ? 1.137   -41.576 -24.513 1.00 35.46  ? 1278 HOH A O   1 
HETATM 4937 O  O   . HOH L 9 .   ? -29.861 -59.501 -19.717 1.00 29.55  ? 1279 HOH A O   1 
HETATM 4938 O  O   . HOH L 9 .   ? -24.592 -69.553 -34.235 1.00 61.44  ? 1280 HOH A O   1 
HETATM 4939 O  O   . HOH L 9 .   ? -5.741  -50.301 -18.761 1.00 29.54  ? 1281 HOH A O   1 
HETATM 4940 O  O   . HOH L 9 .   ? -4.171  -56.998 -13.336 1.00 38.49  ? 1282 HOH A O   1 
HETATM 4941 O  O   . HOH L 9 .   ? -22.620 -27.481 -18.842 1.00 51.11  ? 1283 HOH A O   1 
HETATM 4942 O  O   . HOH L 9 .   ? -13.651 -53.514 -1.478  1.00 22.94  ? 1284 HOH A O   1 
HETATM 4943 O  O   . HOH L 9 .   ? -19.089 -69.611 -8.219  1.00 24.89  ? 1285 HOH A O   1 
HETATM 4944 O  O   . HOH L 9 .   ? -31.681 -59.968 -15.892 1.00 26.93  ? 1286 HOH A O   1 
HETATM 4945 O  O   . HOH L 9 .   ? -20.610 -50.127 1.237   1.00 33.24  ? 1287 HOH A O   1 
HETATM 4946 O  O   . HOH L 9 .   ? -8.841  -37.155 -19.574 1.00 48.18  ? 1288 HOH A O   1 
HETATM 4947 O  O   . HOH L 9 .   ? -1.171  -68.405 -21.480 1.00 51.38  ? 1289 HOH A O   1 
HETATM 4948 O  O   . HOH L 9 .   ? -5.696  -33.014 -17.483 1.00 42.17  ? 1290 HOH A O   1 
HETATM 4949 O  O   . HOH L 9 .   ? 1.411   -38.147 -21.320 1.00 51.27  ? 1291 HOH A O   1 
HETATM 4950 O  O   . HOH L 9 .   ? -25.012 -53.385 -1.923  1.00 23.91  ? 1292 HOH A O   1 
HETATM 4951 O  O   . HOH L 9 .   ? -30.155 -60.695 -23.063 1.00 28.00  ? 1293 HOH A O   1 
HETATM 4952 O  O   . HOH L 9 .   ? -35.992 -51.163 -22.487 1.00 61.12  ? 1294 HOH A O   1 
HETATM 4953 O  O   . HOH L 9 .   ? -19.716 -43.616 -37.872 1.00 58.57  ? 1295 HOH A O   1 
HETATM 4954 O  O   . HOH L 9 .   ? -20.771 -31.542 -29.260 1.00 32.97  ? 1296 HOH A O   1 
HETATM 4955 O  O   . HOH L 9 .   ? -32.035 -18.942 -30.814 1.00 52.98  ? 1297 HOH A O   1 
HETATM 4956 O  O   . HOH L 9 .   ? 5.906   -19.828 -43.337 1.00 53.50  ? 1298 HOH A O   1 
HETATM 4957 O  O   . HOH L 9 .   ? -14.265 -56.332 -1.543  1.00 19.42  ? 1299 HOH A O   1 
HETATM 4958 O  O   . HOH L 9 .   ? -21.141 -65.065 -41.096 1.00 41.03  ? 1300 HOH A O   1 
HETATM 4959 O  O   . HOH L 9 .   ? -19.100 -68.416 -1.925  1.00 43.28  ? 1301 HOH A O   1 
HETATM 4960 O  O   . HOH L 9 .   ? -4.627  -62.485 -4.664  0.46 40.09  ? 1302 HOH A O   1 
HETATM 4961 O  O   . HOH L 9 .   ? -12.023 -44.041 -16.329 1.00 46.27  ? 1303 HOH A O   1 
HETATM 4962 O  O   . HOH L 9 .   ? 6.544   -29.416 -43.878 1.00 45.09  ? 1304 HOH A O   1 
HETATM 4963 O  O   . HOH L 9 .   ? -7.060  -60.499 -30.637 1.00 59.53  ? 1305 HOH A O   1 
HETATM 4964 O  O   . HOH L 9 .   ? -13.653 -51.221 -43.170 1.00 49.35  ? 1306 HOH A O   1 
HETATM 4965 O  O   . HOH L 9 .   ? -20.539 -67.298 -25.322 1.00 27.59  ? 1307 HOH A O   1 
HETATM 4966 O  O   . HOH L 9 .   ? -8.454  -17.036 -39.229 1.00 42.56  ? 1308 HOH A O   1 
HETATM 4967 O  O   . HOH L 9 .   ? -14.872 -54.185 -4.115  1.00 22.64  ? 1309 HOH A O   1 
HETATM 4968 O  O   . HOH L 9 .   ? -35.222 -59.264 -0.423  1.00 38.76  ? 1310 HOH A O   1 
HETATM 4969 O  O   . HOH L 9 .   ? -12.491 -75.327 -26.592 1.00 60.30  ? 1311 HOH A O   1 
HETATM 4970 O  O   . HOH L 9 .   ? 3.504   -31.342 -37.229 1.00 28.56  ? 1312 HOH A O   1 
HETATM 4971 O  O   . HOH L 9 .   ? -29.418 -50.658 -29.756 1.00 53.92  ? 1313 HOH A O   1 
HETATM 4972 O  O   . HOH L 9 .   ? -22.041 -44.140 -31.183 1.00 37.65  ? 1314 HOH A O   1 
HETATM 4973 O  O   . HOH L 9 .   ? -0.439  -35.623 -28.123 1.00 30.23  ? 1315 HOH A O   1 
HETATM 4974 O  O   . HOH L 9 .   ? -6.114  -39.712 -45.243 1.00 62.73  ? 1316 HOH A O   1 
HETATM 4975 O  O   . HOH L 9 .   ? -4.910  -56.342 -31.681 1.00 27.97  ? 1317 HOH A O   1 
HETATM 4976 O  O   . HOH L 9 .   ? -5.894  -48.970 -21.214 1.00 26.22  ? 1318 HOH A O   1 
HETATM 4977 O  O   . HOH L 9 .   ? -15.739 -54.852 -43.733 1.00 48.27  ? 1319 HOH A O   1 
HETATM 4978 O  O   . HOH L 9 .   ? -3.733  -15.330 -20.612 1.00 46.35  ? 1320 HOH A O   1 
HETATM 4979 O  O   . HOH L 9 .   ? -17.099 -28.630 -41.004 1.00 56.34  ? 1321 HOH A O   1 
HETATM 4980 O  O   . HOH L 9 .   ? -35.875 -54.045 -3.284  1.00 29.83  ? 1322 HOH A O   1 
HETATM 4981 O  O   . HOH L 9 .   ? -24.304 -57.691 -46.561 1.00 44.60  ? 1323 HOH A O   1 
HETATM 4982 O  O   . HOH L 9 .   ? -12.426 -66.931 -29.588 1.00 32.11  ? 1324 HOH A O   1 
HETATM 4983 O  O   . HOH L 9 .   ? -20.183 -37.802 -36.589 1.00 28.15  ? 1325 HOH A O   1 
HETATM 4984 O  O   . HOH L 9 .   ? -6.358  -43.002 -21.240 1.00 49.26  ? 1326 HOH A O   1 
HETATM 4985 O  O   . HOH L 9 .   ? -3.796  -70.832 -9.021  1.00 38.02  ? 1327 HOH A O   1 
HETATM 4986 O  O   . HOH L 9 .   ? -24.442 -68.627 -38.234 1.00 51.25  ? 1328 HOH A O   1 
HETATM 4987 O  O   . HOH L 9 .   ? -27.890 -16.698 -32.357 1.00 38.93  ? 1329 HOH A O   1 
HETATM 4988 O  O   . HOH L 9 .   ? -34.049 -70.042 -18.353 1.00 37.64  ? 1330 HOH A O   1 
HETATM 4989 O  O   . HOH L 9 .   ? -20.101 -46.303 -25.372 1.00 34.15  ? 1331 HOH A O   1 
HETATM 4990 O  O   . HOH L 9 .   ? -5.848  -68.424 -27.413 1.00 27.94  ? 1332 HOH A O   1 
HETATM 4991 O  O   . HOH L 9 .   ? -15.051 -48.498 -18.653 1.00 30.79  ? 1333 HOH A O   1 
HETATM 4992 O  O   . HOH L 9 .   ? -20.274 -70.765 -5.923  1.00 38.25  ? 1334 HOH A O   1 
HETATM 4993 O  O   . HOH L 9 .   ? -17.426 -71.521 -22.772 1.00 42.26  ? 1335 HOH A O   1 
HETATM 4994 O  O   . HOH L 9 .   ? -31.193 -45.107 -15.582 1.00 48.39  ? 1336 HOH A O   1 
HETATM 4995 O  O   . HOH L 9 .   ? -39.460 -64.975 -1.901  0.50 30.33  ? 1337 HOH A O   1 
HETATM 4996 O  O   . HOH L 9 .   ? -23.012 -75.211 -9.232  1.00 41.14  ? 1338 HOH A O   1 
HETATM 4997 O  O   . HOH L 9 .   ? -5.722  -58.613 -36.936 1.00 50.48  ? 1339 HOH A O   1 
HETATM 4998 O  O   . HOH L 9 .   ? -37.627 -68.133 -12.369 1.00 44.20  ? 1340 HOH A O   1 
HETATM 4999 O  O   . HOH L 9 .   ? -4.157  -52.673 -38.497 1.00 51.78  ? 1341 HOH A O   1 
HETATM 5000 O  O   . HOH L 9 .   ? -29.909 -61.414 -33.077 1.00 48.02  ? 1342 HOH A O   1 
HETATM 5001 O  O   . HOH L 9 .   ? -27.293 -15.388 -19.793 1.00 51.34  ? 1343 HOH A O   1 
HETATM 5002 O  O   . HOH L 9 .   ? -24.808 -30.538 -39.646 1.00 58.01  ? 1344 HOH A O   1 
HETATM 5003 O  O   . HOH L 9 .   ? -15.149 -36.637 -40.294 1.00 51.14  ? 1345 HOH A O   1 
HETATM 5004 O  O   . HOH L 9 .   ? -2.356  -39.596 -45.816 1.00 41.07  ? 1346 HOH A O   1 
HETATM 5005 O  O   . HOH L 9 .   ? -18.997 -45.342 -9.175  1.00 58.93  ? 1347 HOH A O   1 
HETATM 5006 O  O   . HOH L 9 .   ? -8.540  -30.812 -15.248 1.00 49.54  ? 1348 HOH A O   1 
HETATM 5007 O  O   . HOH L 9 .   ? -35.697 -58.498 -27.280 1.00 46.28  ? 1349 HOH A O   1 
HETATM 5008 O  O   . HOH L 9 .   ? -26.848 -51.170 -1.757  1.00 32.82  ? 1350 HOH A O   1 
HETATM 5009 O  O   . HOH L 9 .   ? -22.914 -20.669 -37.645 1.00 44.97  ? 1351 HOH A O   1 
HETATM 5010 O  O   . HOH L 9 .   ? -34.788 -59.378 -29.322 1.00 55.26  ? 1352 HOH A O   1 
HETATM 5011 O  O   . HOH L 9 .   ? -8.603  -27.484 -46.517 1.00 54.09  ? 1353 HOH A O   1 
HETATM 5012 O  O   . HOH L 9 .   ? -31.290 -71.733 -13.516 1.00 54.46  ? 1354 HOH A O   1 
HETATM 5013 O  O   . HOH L 9 .   ? -22.582 -29.479 -14.530 1.00 56.81  ? 1355 HOH A O   1 
HETATM 5014 O  O   . HOH L 9 .   ? -19.265 -14.350 -37.887 1.00 68.25  ? 1356 HOH A O   1 
HETATM 5015 O  O   . HOH L 9 .   ? -37.421 -52.325 -12.876 1.00 26.62  ? 1357 HOH A O   1 
HETATM 5016 O  O   . HOH L 9 .   ? -10.565 -41.207 -38.102 1.00 41.87  ? 1358 HOH A O   1 
HETATM 5017 O  O   . HOH L 9 .   ? -3.785  -56.460 -7.036  1.00 27.73  ? 1359 HOH A O   1 
HETATM 5018 O  O   . HOH L 9 .   ? -11.021 -46.325 3.965   1.00 42.25  ? 1360 HOH A O   1 
HETATM 5019 O  O   . HOH L 9 .   ? -7.754  -61.846 -33.743 1.00 47.58  ? 1361 HOH A O   1 
HETATM 5020 O  O   . HOH L 9 .   ? -2.210  -70.274 -17.813 1.00 45.99  ? 1362 HOH A O   1 
HETATM 5021 O  O   . HOH L 9 .   ? 9.917   -38.001 -39.359 1.00 41.30  ? 1363 HOH A O   1 
HETATM 5022 O  O   . HOH L 9 .   ? -23.303 -48.013 -33.782 1.00 49.81  ? 1364 HOH A O   1 
HETATM 5023 O  O   . HOH L 9 .   ? -13.654 -11.356 -32.003 1.00 50.99  ? 1365 HOH A O   1 
HETATM 5024 O  O   . HOH L 9 .   ? -17.273 -57.403 -43.656 1.00 34.40  ? 1366 HOH A O   1 
HETATM 5025 O  O   . HOH L 9 .   ? -27.215 -26.707 -35.753 1.00 35.07  ? 1367 HOH A O   1 
HETATM 5026 O  O   . HOH L 9 .   ? -35.033 -67.514 -5.536  1.00 49.44  ? 1368 HOH A O   1 
HETATM 5027 O  O   . HOH L 9 .   ? -5.903  -68.988 -7.341  1.00 33.76  ? 1369 HOH A O   1 
HETATM 5028 O  O   . HOH L 9 .   ? 3.564   -34.182 -14.267 1.00 50.96  ? 1370 HOH A O   1 
HETATM 5029 O  O   . HOH L 9 .   ? -7.712  -29.923 -46.152 1.00 40.53  ? 1371 HOH A O   1 
HETATM 5030 O  O   . HOH L 9 .   ? -38.048 -37.865 -26.239 1.00 57.78  ? 1372 HOH A O   1 
HETATM 5031 O  O   . HOH L 9 .   ? -0.170  -48.011 -36.389 1.00 34.28  ? 1373 HOH A O   1 
HETATM 5032 O  O   . HOH L 9 .   ? -9.672  -54.914 -41.459 1.00 55.45  ? 1374 HOH A O   1 
HETATM 5033 O  O   . HOH L 9 .   ? -28.738 -62.896 -25.363 1.00 33.04  ? 1375 HOH A O   1 
HETATM 5034 O  O   . HOH L 9 .   ? -10.574 -70.322 -24.155 0.46 35.75  ? 1376 HOH A O   1 
HETATM 5035 O  O   . HOH L 9 .   ? -10.050 -25.491 -12.347 1.00 50.29  ? 1377 HOH A O   1 
HETATM 5036 O  O   . HOH L 9 .   ? -7.207  -57.614 -1.176  1.00 39.71  ? 1378 HOH A O   1 
HETATM 5037 O  O   . HOH L 9 .   ? -18.754 -49.437 -35.080 1.00 41.83  ? 1379 HOH A O   1 
HETATM 5038 O  O   . HOH L 9 .   ? -23.435 -49.359 -42.003 1.00 42.26  ? 1380 HOH A O   1 
HETATM 5039 O  O   . HOH L 9 .   ? -12.739 -37.866 -22.484 1.00 46.57  ? 1381 HOH A O   1 
HETATM 5040 O  O   . HOH L 9 .   ? -26.486 -27.899 -42.404 1.00 52.74  ? 1382 HOH A O   1 
HETATM 5041 O  O   . HOH L 9 .   ? -11.699 -71.889 -15.671 1.00 22.14  ? 1383 HOH A O   1 
HETATM 5042 O  O   . HOH L 9 .   ? -13.320 -68.523 -6.216  1.00 37.64  ? 1384 HOH A O   1 
HETATM 5043 O  O   . HOH L 9 .   ? -8.915  -35.423 -44.711 1.00 59.13  ? 1385 HOH A O   1 
HETATM 5044 O  O   . HOH L 9 .   ? 13.460  -30.499 -19.666 1.00 44.31  ? 1386 HOH A O   1 
HETATM 5045 O  O   . HOH L 9 .   ? -14.583 -20.855 -16.879 0.50 45.60  ? 1387 HOH A O   1 
HETATM 5046 O  O   . HOH L 9 .   ? -38.616 -51.844 -20.420 1.00 55.62  ? 1388 HOH A O   1 
HETATM 5047 O  O   . HOH L 9 .   ? 0.786   -31.139 -47.041 1.00 48.60  ? 1389 HOH A O   1 
HETATM 5048 O  O   . HOH L 9 .   ? -14.502 -46.033 3.208   1.00 49.58  ? 1390 HOH A O   1 
HETATM 5049 O  O   . HOH L 9 .   ? -37.642 -54.974 -24.647 1.00 61.36  ? 1391 HOH A O   1 
HETATM 5050 O  O   . HOH L 9 .   ? -23.334 -45.439 -9.073  1.00 48.78  ? 1392 HOH A O   1 
HETATM 5051 O  O   . HOH L 9 .   ? -0.919  -32.350 -25.402 1.00 28.92  ? 1393 HOH A O   1 
HETATM 5052 O  O   . HOH L 9 .   ? -28.375 -49.160 -31.459 1.00 52.37  ? 1394 HOH A O   1 
HETATM 5053 O  O   . HOH L 9 .   ? -3.029  -58.027 -24.648 1.00 20.18  ? 1395 HOH A O   1 
HETATM 5054 O  O   . HOH L 9 .   ? -6.564  -37.062 -20.559 1.00 48.92  ? 1396 HOH A O   1 
HETATM 5055 O  O   . HOH L 9 .   ? -18.203 -69.243 -24.718 1.00 36.87  ? 1397 HOH A O   1 
HETATM 5056 O  O   . HOH L 9 .   ? -14.821 -56.874 -41.914 1.00 30.14  ? 1398 HOH A O   1 
HETATM 5057 O  O   . HOH L 9 .   ? -0.064  -45.924 -42.708 1.00 50.17  ? 1399 HOH A O   1 
HETATM 5058 O  O   . HOH L 9 .   ? -26.661 -67.717 -27.908 1.00 24.48  ? 1400 HOH A O   1 
HETATM 5059 O  O   . HOH L 9 .   ? -15.720 -27.080 -45.944 1.00 50.77  ? 1401 HOH A O   1 
HETATM 5060 O  O   . HOH L 9 .   ? -23.027 -63.036 -23.531 1.00 47.29  ? 1402 HOH A O   1 
HETATM 5061 O  O   . HOH L 9 .   ? -34.103 -47.102 -15.581 1.00 54.75  ? 1403 HOH A O   1 
HETATM 5062 O  O   . HOH L 9 .   ? -28.827 -69.473 -22.926 1.00 60.93  ? 1404 HOH A O   1 
HETATM 5063 O  O   . HOH L 9 .   ? -19.156 -64.503 -2.981  1.00 33.94  ? 1405 HOH A O   1 
HETATM 5064 O  O   . HOH L 9 .   ? -12.921 -32.648 -20.480 1.00 35.82  ? 1406 HOH A O   1 
HETATM 5065 O  O   . HOH L 9 .   ? -25.325 -23.488 -41.461 1.00 58.37  ? 1407 HOH A O   1 
HETATM 5066 O  O   . HOH L 9 .   ? 6.142   -39.449 -23.314 0.50 68.97  ? 1408 HOH A O   1 
HETATM 5067 O  O   . HOH L 9 .   ? 0.424   -70.633 -21.343 1.00 40.10  ? 1409 HOH A O   1 
HETATM 5068 O  O   . HOH L 9 .   ? -20.154 -31.289 -26.564 1.00 34.98  ? 1410 HOH A O   1 
HETATM 5069 O  O   . HOH L 9 .   ? -2.297  -34.062 -13.591 1.00 63.24  ? 1411 HOH A O   1 
HETATM 5070 O  O   . HOH L 9 .   ? -19.954 -76.219 -14.762 1.00 54.23  ? 1412 HOH A O   1 
HETATM 5071 O  O   . HOH L 9 .   ? -7.407  -51.198 -10.487 1.00 55.30  ? 1413 HOH A O   1 
HETATM 5072 O  O   . HOH L 9 .   ? -11.614 -39.765 -39.711 1.00 49.68  ? 1414 HOH A O   1 
HETATM 5073 O  O   . HOH L 9 .   ? -4.444  -34.365 -14.496 1.00 51.58  ? 1415 HOH A O   1 
HETATM 5074 O  O   . HOH L 9 .   ? -23.070 -36.792 -32.552 1.00 46.83  ? 1416 HOH A O   1 
HETATM 5075 O  O   . HOH L 9 .   ? -22.722 -37.339 -37.135 1.00 42.75  ? 1417 HOH A O   1 
HETATM 5076 O  O   . HOH L 9 .   ? 4.827   -69.006 -21.607 1.00 36.42  ? 1418 HOH A O   1 
HETATM 5077 O  O   . HOH L 9 .   ? 11.549  -37.132 -19.155 1.00 47.94  ? 1419 HOH A O   1 
HETATM 5078 O  O   . HOH L 9 .   ? 4.471   -62.327 -20.109 1.00 23.99  ? 1420 HOH A O   1 
HETATM 5079 O  O   . HOH L 9 .   ? -2.885  -55.581 -28.823 1.00 25.59  ? 1421 HOH A O   1 
HETATM 5080 O  O   . HOH L 9 .   ? -10.564 -33.950 -43.969 1.00 56.66  ? 1422 HOH A O   1 
HETATM 5081 O  O   . HOH L 9 .   ? 0.000   -58.107 -16.620 0.50 50.14  ? 1423 HOH A O   1 
HETATM 5082 O  O   . HOH L 9 .   ? -21.180 -43.669 -41.774 1.00 61.54  ? 1424 HOH A O   1 
HETATM 5083 O  O   . HOH L 9 .   ? 0.393   -45.246 -36.852 1.00 46.67  ? 1425 HOH A O   1 
HETATM 5084 O  O   . HOH L 9 .   ? -38.266 -27.995 -27.105 1.00 56.53  ? 1426 HOH A O   1 
HETATM 5085 O  O   . HOH L 9 .   ? -10.607 -17.600 -40.513 1.00 51.06  ? 1427 HOH A O   1 
HETATM 5086 O  O   . HOH L 9 .   ? -25.900 -20.061 -38.778 1.00 59.51  ? 1428 HOH A O   1 
HETATM 5087 O  O   . HOH L 9 .   ? -17.618 -41.591 -37.224 1.00 43.40  ? 1429 HOH A O   1 
HETATM 5088 O  O   . HOH L 9 .   ? -7.281  -29.770 -13.432 1.00 54.06  ? 1430 HOH A O   1 
HETATM 5089 O  O   . HOH L 9 .   ? -17.810 -47.029 -15.227 1.00 40.38  ? 1431 HOH A O   1 
HETATM 5090 O  O   . HOH L 9 .   ? -32.083 -13.041 -9.391  1.00 56.76  ? 1432 HOH A O   1 
HETATM 5091 O  O   . HOH L 9 .   ? -10.072 -38.074 -43.451 1.00 50.52  ? 1433 HOH A O   1 
HETATM 5092 O  O   . HOH L 9 .   ? -8.378  -68.143 -28.522 1.00 47.65  ? 1434 HOH A O   1 
HETATM 5093 O  O   . HOH L 9 .   ? -5.638  -30.960 -47.922 1.00 55.03  ? 1435 HOH A O   1 
HETATM 5094 O  O   . HOH L 9 .   ? 5.451   -45.176 -25.991 1.00 40.48  ? 1436 HOH A O   1 
HETATM 5095 O  O   . HOH L 9 .   ? -3.053  -51.778 -15.376 1.00 60.72  ? 1437 HOH A O   1 
HETATM 5096 O  O   . HOH L 9 .   ? -34.657 -49.338 -20.901 1.00 55.76  ? 1438 HOH A O   1 
HETATM 5097 O  O   . HOH L 9 .   ? -9.789  -32.369 -45.955 1.00 66.60  ? 1439 HOH A O   1 
HETATM 5098 O  O   . HOH L 9 .   ? -13.884 -44.786 -10.187 1.00 69.10  ? 1440 HOH A O   1 
HETATM 5099 O  O   . HOH L 9 .   ? -36.541 -61.204 -20.497 1.00 60.64  ? 1441 HOH A O   1 
HETATM 5100 O  O   . HOH L 9 .   ? 4.422   -7.281  -38.095 1.00 70.65  ? 1442 HOH A O   1 
HETATM 5101 O  O   . HOH L 9 .   ? -36.168 -56.543 -4.231  1.00 48.50  ? 1443 HOH A O   1 
HETATM 5102 O  O   . HOH L 9 .   ? -27.152 -73.655 -4.673  1.00 42.34  ? 1444 HOH A O   1 
HETATM 5103 O  O   . HOH L 9 .   ? -29.294 -69.087 -40.084 1.00 54.94  ? 1445 HOH A O   1 
HETATM 5104 O  O   . HOH L 9 .   ? -25.374 -20.530 -4.806  1.00 49.57  ? 1446 HOH A O   1 
HETATM 5105 O  O   . HOH L 9 .   ? -2.181  -52.005 2.013   1.00 70.41  ? 1447 HOH A O   1 
HETATM 5106 O  O   . HOH L 9 .   ? -24.953 -28.628 -22.780 1.00 49.75  ? 1448 HOH A O   1 
HETATM 5107 O  O   . HOH L 9 .   ? -34.704 -70.487 -13.812 1.00 61.01  ? 1449 HOH A O   1 
HETATM 5108 O  O   . HOH L 9 .   ? -30.724 -16.673 -32.089 1.00 48.82  ? 1450 HOH A O   1 
HETATM 5109 O  O   . HOH L 9 .   ? -34.060 -49.477 -10.339 1.00 41.31  ? 1451 HOH A O   1 
HETATM 5110 O  O   . HOH L 9 .   ? -1.828  -65.206 -15.741 1.00 45.87  ? 1452 HOH A O   1 
HETATM 5111 O  O   . HOH L 9 .   ? -42.452 -66.191 -9.687  1.00 53.22  ? 1453 HOH A O   1 
HETATM 5112 O  O   . HOH L 9 .   ? -16.246 -49.072 -16.204 1.00 21.35  ? 1454 HOH A O   1 
HETATM 5113 O  O   . HOH L 9 .   ? -37.904 -52.193 -3.965  1.00 40.02  ? 1455 HOH A O   1 
HETATM 5114 O  O   . HOH L 9 .   ? -17.856 -27.886 -44.494 1.00 52.93  ? 1456 HOH A O   1 
HETATM 5115 O  O   . HOH L 9 .   ? -15.736 -69.073 -5.995  1.00 26.20  ? 1457 HOH A O   1 
HETATM 5116 O  O   . HOH L 9 .   ? -3.112  -74.487 -19.306 0.46 47.55  ? 1458 HOH A O   1 
HETATM 5117 O  O   . HOH L 9 .   ? -19.173 -39.601 -38.264 1.00 45.71  ? 1459 HOH A O   1 
HETATM 5118 O  O   . HOH L 9 .   ? -34.682 -69.901 -9.240  1.00 54.82  ? 1460 HOH A O   1 
HETATM 5119 O  O   . HOH L 9 .   ? -40.585 -61.815 -3.221  1.00 54.86  ? 1461 HOH A O   1 
HETATM 5120 O  O   . HOH L 9 .   ? -3.220  -51.866 -4.174  1.00 68.94  ? 1462 HOH A O   1 
HETATM 5121 O  O   . HOH L 9 .   ? -16.861 -39.013 -39.682 1.00 53.51  ? 1463 HOH A O   1 
HETATM 5122 O  O   . HOH L 9 .   ? -3.536  -50.367 -17.788 1.00 50.75  ? 1464 HOH A O   1 
HETATM 5123 O  O   . HOH L 9 .   ? -19.462 -58.495 -48.336 1.00 67.24  ? 1465 HOH A O   1 
HETATM 5124 O  O   . HOH L 9 .   ? -30.955 -59.438 -34.473 1.00 52.81  ? 1466 HOH A O   1 
HETATM 5125 O  O   . HOH L 9 .   ? 0.289   -62.315 -17.746 1.00 33.03  ? 1467 HOH A O   1 
HETATM 5126 O  O   . HOH L 9 .   ? -37.598 -60.346 -0.018  0.50 48.26  ? 1468 HOH A O   1 
HETATM 5127 O  O   . HOH L 9 .   ? -13.447 -69.753 -23.124 0.46 44.69  ? 1469 HOH A O   1 
HETATM 5128 O  O   . HOH L 9 .   ? -6.728  -44.959 -17.208 1.00 53.05  ? 1470 HOH A O   1 
HETATM 5129 O  O   . HOH L 9 .   ? -15.549 -41.553 -38.491 1.00 37.50  ? 1471 HOH A O   1 
HETATM 5130 O  O   . HOH L 9 .   ? -1.233  -62.889 -15.399 1.00 50.64  ? 1472 HOH A O   1 
HETATM 5131 O  O   . HOH L 9 .   ? -5.065  -64.984 -31.038 1.00 52.94  ? 1473 HOH A O   1 
HETATM 5132 O  O   . HOH L 9 .   ? -15.712 -45.758 -19.643 1.00 51.80  ? 1474 HOH A O   1 
HETATM 5133 O  O   . HOH L 9 .   ? -24.182 -35.707 -34.932 1.00 52.12  ? 1475 HOH A O   1 
HETATM 5134 O  O   . HOH L 9 .   ? -41.286 -56.523 -13.695 1.00 30.14  ? 1476 HOH A O   1 
HETATM 5135 O  O   . HOH L 9 .   ? -9.671  -23.687 -3.565  1.00 55.65  ? 1477 HOH A O   1 
HETATM 5136 O  O   . HOH L 9 .   ? 0.000   -58.107 -28.483 0.50 28.35  ? 1478 HOH A O   1 
HETATM 5137 O  O   . HOH L 9 .   ? -37.289 -64.513 0.354   0.50 35.08  ? 1479 HOH A O   1 
HETATM 5138 O  O   . HOH L 9 .   ? -10.848 -68.267 -35.845 1.00 63.17  ? 1480 HOH A O   1 
HETATM 5139 O  O   . HOH L 9 .   ? -1.228  -58.579 -32.023 1.00 70.95  ? 1481 HOH A O   1 
HETATM 5140 O  O   . HOH L 9 .   ? -25.534 -2.088  -28.980 1.00 62.65  ? 1482 HOH A O   1 
HETATM 5141 O  O   . HOH L 9 .   ? -27.761 -40.232 -5.449  1.00 60.07  ? 1483 HOH A O   1 
HETATM 5142 O  O   . HOH L 9 .   ? -9.546  -40.370 -42.149 1.00 56.49  ? 1484 HOH A O   1 
HETATM 5143 O  O   . HOH L 9 .   ? -11.750 -28.727 -48.250 1.00 70.63  ? 1485 HOH A O   1 
HETATM 5144 O  O   . HOH L 9 .   ? -2.824  -56.392 -33.734 1.00 51.06  ? 1486 HOH A O   1 
HETATM 5145 O  O   . HOH L 9 .   ? -4.834  -66.513 -6.127  1.00 60.99  ? 1487 HOH A O   1 
HETATM 5146 O  O   . HOH L 9 .   ? -9.906  -27.699 -11.866 1.00 52.49  ? 1488 HOH A O   1 
HETATM 5147 O  O   . HOH L 9 .   ? -4.247  -49.112 3.153   1.00 65.08  ? 1489 HOH A O   1 
HETATM 5148 O  O   . HOH L 9 .   ? -8.582  -62.992 -41.559 1.00 65.84  ? 1490 HOH A O   1 
HETATM 5149 O  O   . HOH L 9 .   ? -18.190 -67.802 -6.401  1.00 23.46  ? 1491 HOH A O   1 
HETATM 5150 O  O   . HOH L 9 .   ? -25.158 -27.986 -19.678 1.00 51.66  ? 1492 HOH A O   1 
HETATM 5151 O  O   . HOH L 9 .   ? -35.825 -47.818 -14.044 1.00 52.12  ? 1493 HOH A O   1 
HETATM 5152 O  O   . HOH L 9 .   ? -12.204 -36.336 -42.576 1.00 46.30  ? 1494 HOH A O   1 
HETATM 5153 O  O   . HOH L 9 .   ? 16.584  -34.174 -26.816 1.00 56.31  ? 1495 HOH A O   1 
HETATM 5154 O  O   . HOH L 9 .   ? -1.624  -55.752 -5.986  1.00 49.15  ? 1496 HOH A O   1 
HETATM 5155 O  O   . HOH L 9 .   ? -2.800  -59.421 -0.637  1.00 35.42  ? 1497 HOH A O   1 
HETATM 5156 O  O   . HOH L 9 .   ? -19.939 -68.111 -4.343  1.00 28.85  ? 1498 HOH A O   1 
HETATM 5157 O  O   . HOH L 9 .   ? 0.762   -42.983 -21.780 1.00 49.78  ? 1499 HOH A O   1 
HETATM 5158 O  O   . HOH L 9 .   ? 15.702  -14.601 -40.625 1.00 64.03  ? 1500 HOH A O   1 
HETATM 5159 O  O   . HOH L 9 .   ? -5.686  -64.106 -6.615  0.46 36.58  ? 1501 HOH A O   1 
HETATM 5160 O  O   . HOH L 9 .   ? -1.605  -59.111 -3.402  1.00 51.42  ? 1502 HOH A O   1 
HETATM 5161 O  O   . HOH L 9 .   ? -44.215 -67.891 -16.003 1.00 60.20  ? 1503 HOH A O   1 
HETATM 5162 O  O   . HOH L 9 .   ? 10.208  -20.699 -25.631 1.00 50.25  ? 1504 HOH A O   1 
HETATM 5163 O  O   . HOH L 9 .   ? -27.076 -29.822 -18.964 1.00 71.74  ? 1505 HOH A O   1 
HETATM 5164 O  O   . HOH L 9 .   ? -28.322 -55.701 -45.234 1.00 56.67  ? 1506 HOH A O   1 
HETATM 5165 O  O   . HOH L 9 .   ? 13.253  -25.526 -26.563 1.00 63.04  ? 1507 HOH A O   1 
HETATM 5166 O  O   . HOH L 9 .   ? -2.758  -60.306 -7.996  0.46 62.28  ? 1508 HOH A O   1 
HETATM 5167 O  O   . HOH L 9 .   ? -4.081  -61.763 -10.027 0.46 38.13  ? 1509 HOH A O   1 
HETATM 5168 O  O   . HOH L 9 .   ? -42.791 -61.128 -1.858  1.00 60.98  ? 1510 HOH A O   1 
# 
