data_7I2S
# 
_entry.id   7I2S 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   7I2S         pdb_00007i2s 10.2210/pdb7i2s/pdb 
WWPDB D_1001408243 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-02 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.entry_id                        7I2S 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.recvd_initial_deposition_date   2025-03-06 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.SG_entry                        ? 
_pdbx_database_status.pdb_format_compatible           Y 
_pdbx_database_status.methods_development_category    ? 
# 
_pdbx_contact_author.id                 1 
_pdbx_contact_author.email              fr193@cabm.rutgers.edu 
_pdbx_contact_author.name_first         'Francesc Xavier' 
_pdbx_contact_author.name_last          Ruiz 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0457-0030 
_pdbx_contact_author.name_mi            ? 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Aschenbrenner, J.C.' 1  ? 
'Saini, M.'           2  ? 
'Chopra, A.'          3  ? 
'Marples, P.G.'       4  ? 
'Balcomb, B.H.'       5  ? 
'Lithgo, R.M.'        6  ? 
'Fearon, D.'          7  ? 
'von Delft, F.'       8  ? 
'Ruiz, F.X.'          9  ? 
'Arnold, E.'          10 ? 
# 
_citation.id                        primary 
_citation.title                     
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_volume            ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.year                      ? 
_citation.journal_id_ASTM           ? 
_citation.country                   ? 
_citation.journal_id_ISSN           ? 
_citation.journal_id_CSD            0353 
_citation.book_publisher            ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_DOI      ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.identifier_ORCID 
_citation_author.ordinal 
primary 'Aschenbrenner, J.C.' ? 1  
primary 'Saini, M.'           ? 2  
primary 'Chopra, A.'          ? 3  
primary 'Marples, P.G.'       ? 4  
primary 'Balcomb, B.H.'       ? 5  
primary 'Lithgo, R.M.'        ? 6  
primary 'Fearon, D.'          ? 7  
primary 'von Delft, F.'       ? 8  
primary 'Ruiz, F.X.'          ? 9  
primary 'Arnold, E.'          ? 10 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'NS5 RNA-dependent RNA polymerase'            73890.008 1   ? ? ? ? 
2 non-polymer syn 'ZINC ION'                                    65.409    2   ? ? ? ? 
3 non-polymer syn '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'        195.237   1   ? ? ? ? 
4 non-polymer syn 'DIMETHYL SULFOXIDE'                          78.133    3   ? ? ? ? 
5 non-polymer syn 'DI(HYDROXYETHYL)ETHER'                       106.120   2   ? ? ? ? 
6 non-polymer syn 'PHOSPHATE ION'                               94.971    2   ? ? ? ? 
7 non-polymer syn '3-cyclohexyl-1-(morpholin-4-yl)propan-1-one' 225.327   1   ? ? ? ? 
8 non-polymer syn 'CHLORIDE ION'                                35.453    1   ? ? ? ? 
9 water       nat water                                         18.015    419 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION'                                    ZN  
3 '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'        MES 
4 'DIMETHYL SULFOXIDE'                          DMS 
5 'DI(HYDROXYETHYL)ETHER'                       PEG 
6 'PHOSPHATE ION'                               PO4 
7 '3-cyclohexyl-1-(morpholin-4-yl)propan-1-one' NW4 
8 'CHLORIDE ION'                                CL  
9 water                                         HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PRO n 
1 3   GLY n 
1 4   ILE n 
1 5   GLU n 
1 6   SER n 
1 7   GLU n 
1 8   THR n 
1 9   PRO n 
1 10  ASN n 
1 11  LEU n 
1 12  ASP n 
1 13  ILE n 
1 14  ILE n 
1 15  GLY n 
1 16  LYS n 
1 17  ARG n 
1 18  ILE n 
1 19  GLU n 
1 20  LYS n 
1 21  ILE n 
1 22  LYS n 
1 23  GLN n 
1 24  GLU n 
1 25  HIS n 
1 26  GLU n 
1 27  THR n 
1 28  SER n 
1 29  TRP n 
1 30  HIS n 
1 31  TYR n 
1 32  ASP n 
1 33  GLN n 
1 34  ASP n 
1 35  HIS n 
1 36  PRO n 
1 37  TYR n 
1 38  LYS n 
1 39  THR n 
1 40  TRP n 
1 41  ALA n 
1 42  TYR n 
1 43  HIS n 
1 44  GLY n 
1 45  SER n 
1 46  TYR n 
1 47  GLU n 
1 48  THR n 
1 49  LYS n 
1 50  GLN n 
1 51  THR n 
1 52  GLY n 
1 53  SER n 
1 54  ALA n 
1 55  SER n 
1 56  SER n 
1 57  MET n 
1 58  VAL n 
1 59  ASN n 
1 60  GLY n 
1 61  VAL n 
1 62  VAL n 
1 63  ARG n 
1 64  LEU n 
1 65  LEU n 
1 66  THR n 
1 67  LYS n 
1 68  PRO n 
1 69  TRP n 
1 70  ASP n 
1 71  ILE n 
1 72  ILE n 
1 73  PRO n 
1 74  MET n 
1 75  VAL n 
1 76  THR n 
1 77  GLN n 
1 78  MET n 
1 79  ALA n 
1 80  MET n 
1 81  THR n 
1 82  ASP n 
1 83  THR n 
1 84  THR n 
1 85  PRO n 
1 86  PHE n 
1 87  GLY n 
1 88  GLN n 
1 89  GLN n 
1 90  ARG n 
1 91  VAL n 
1 92  PHE n 
1 93  LYS n 
1 94  GLU n 
1 95  LYS n 
1 96  VAL n 
1 97  ASP n 
1 98  THR n 
1 99  ARG n 
1 100 THR n 
1 101 GLN n 
1 102 GLU n 
1 103 PRO n 
1 104 LYS n 
1 105 GLU n 
1 106 GLY n 
1 107 THR n 
1 108 LYS n 
1 109 LYS n 
1 110 LEU n 
1 111 MET n 
1 112 LYS n 
1 113 ILE n 
1 114 THR n 
1 115 ALA n 
1 116 GLU n 
1 117 TRP n 
1 118 LEU n 
1 119 TRP n 
1 120 LYS n 
1 121 GLU n 
1 122 LEU n 
1 123 GLY n 
1 124 LYS n 
1 125 LYS n 
1 126 LYS n 
1 127 THR n 
1 128 PRO n 
1 129 ARG n 
1 130 MET n 
1 131 CYS n 
1 132 THR n 
1 133 ARG n 
1 134 GLU n 
1 135 GLU n 
1 136 PHE n 
1 137 THR n 
1 138 ARG n 
1 139 LYS n 
1 140 VAL n 
1 141 ARG n 
1 142 SER n 
1 143 ASN n 
1 144 ALA n 
1 145 ALA n 
1 146 LEU n 
1 147 GLY n 
1 148 ALA n 
1 149 ILE n 
1 150 PHE n 
1 151 THR n 
1 152 ASP n 
1 153 GLU n 
1 154 ASN n 
1 155 LYS n 
1 156 TRP n 
1 157 LYS n 
1 158 SER n 
1 159 ALA n 
1 160 ARG n 
1 161 GLU n 
1 162 ALA n 
1 163 VAL n 
1 164 GLU n 
1 165 ASP n 
1 166 SER n 
1 167 GLY n 
1 168 PHE n 
1 169 TRP n 
1 170 GLU n 
1 171 LEU n 
1 172 VAL n 
1 173 ASP n 
1 174 LYS n 
1 175 GLU n 
1 176 ARG n 
1 177 ASN n 
1 178 LEU n 
1 179 HIS n 
1 180 LEU n 
1 181 GLU n 
1 182 GLY n 
1 183 LYS n 
1 184 CYS n 
1 185 GLU n 
1 186 THR n 
1 187 CYS n 
1 188 VAL n 
1 189 TYR n 
1 190 ASN n 
1 191 MET n 
1 192 MET n 
1 193 GLY n 
1 194 LYS n 
1 195 ARG n 
1 196 GLU n 
1 197 LYS n 
1 198 LYS n 
1 199 LEU n 
1 200 GLY n 
1 201 GLU n 
1 202 PHE n 
1 203 GLY n 
1 204 LYS n 
1 205 ALA n 
1 206 LYS n 
1 207 GLY n 
1 208 SER n 
1 209 ARG n 
1 210 ALA n 
1 211 ILE n 
1 212 TRP n 
1 213 TYR n 
1 214 MET n 
1 215 TRP n 
1 216 LEU n 
1 217 GLY n 
1 218 ALA n 
1 219 ARG n 
1 220 PHE n 
1 221 LEU n 
1 222 GLU n 
1 223 PHE n 
1 224 GLU n 
1 225 ALA n 
1 226 LEU n 
1 227 GLY n 
1 228 PHE n 
1 229 LEU n 
1 230 ASN n 
1 231 GLU n 
1 232 ASP n 
1 233 HIS n 
1 234 TRP n 
1 235 PHE n 
1 236 SER n 
1 237 ARG n 
1 238 GLU n 
1 239 ASN n 
1 240 SER n 
1 241 LEU n 
1 242 SER n 
1 243 GLY n 
1 244 VAL n 
1 245 GLU n 
1 246 GLY n 
1 247 GLU n 
1 248 GLY n 
1 249 LEU n 
1 250 HIS n 
1 251 LYS n 
1 252 LEU n 
1 253 GLY n 
1 254 TYR n 
1 255 ILE n 
1 256 LEU n 
1 257 ARG n 
1 258 ASP n 
1 259 VAL n 
1 260 SER n 
1 261 LYS n 
1 262 LYS n 
1 263 GLU n 
1 264 GLY n 
1 265 GLY n 
1 266 ALA n 
1 267 MET n 
1 268 TYR n 
1 269 ALA n 
1 270 ASP n 
1 271 ASP n 
1 272 THR n 
1 273 ALA n 
1 274 GLY n 
1 275 TRP n 
1 276 ASP n 
1 277 THR n 
1 278 ARG n 
1 279 ILE n 
1 280 THR n 
1 281 LEU n 
1 282 GLU n 
1 283 ASP n 
1 284 LEU n 
1 285 LYS n 
1 286 ASN n 
1 287 GLU n 
1 288 GLU n 
1 289 MET n 
1 290 VAL n 
1 291 THR n 
1 292 ASN n 
1 293 HIS n 
1 294 MET n 
1 295 GLU n 
1 296 GLY n 
1 297 GLU n 
1 298 HIS n 
1 299 LYS n 
1 300 LYS n 
1 301 LEU n 
1 302 ALA n 
1 303 GLU n 
1 304 ALA n 
1 305 ILE n 
1 306 PHE n 
1 307 LYS n 
1 308 LEU n 
1 309 THR n 
1 310 TYR n 
1 311 GLN n 
1 312 ASN n 
1 313 LYS n 
1 314 VAL n 
1 315 VAL n 
1 316 ARG n 
1 317 VAL n 
1 318 GLN n 
1 319 ARG n 
1 320 PRO n 
1 321 THR n 
1 322 PRO n 
1 323 ARG n 
1 324 GLY n 
1 325 THR n 
1 326 VAL n 
1 327 MET n 
1 328 ASP n 
1 329 ILE n 
1 330 ILE n 
1 331 SER n 
1 332 ARG n 
1 333 ARG n 
1 334 ASP n 
1 335 GLN n 
1 336 ARG n 
1 337 GLY n 
1 338 SER n 
1 339 GLY n 
1 340 GLN n 
1 341 VAL n 
1 342 VAL n 
1 343 THR n 
1 344 TYR n 
1 345 GLY n 
1 346 LEU n 
1 347 ASN n 
1 348 THR n 
1 349 PHE n 
1 350 THR n 
1 351 ASN n 
1 352 MET n 
1 353 GLU n 
1 354 ALA n 
1 355 GLN n 
1 356 LEU n 
1 357 ILE n 
1 358 ARG n 
1 359 GLN n 
1 360 MET n 
1 361 GLU n 
1 362 GLY n 
1 363 GLU n 
1 364 GLY n 
1 365 VAL n 
1 366 PHE n 
1 367 LYS n 
1 368 SER n 
1 369 ILE n 
1 370 GLN n 
1 371 HIS n 
1 372 LEU n 
1 373 THR n 
1 374 VAL n 
1 375 THR n 
1 376 GLU n 
1 377 GLU n 
1 378 ILE n 
1 379 ALA n 
1 380 VAL n 
1 381 LYS n 
1 382 ASN n 
1 383 TRP n 
1 384 LEU n 
1 385 VAL n 
1 386 ARG n 
1 387 VAL n 
1 388 GLY n 
1 389 ARG n 
1 390 GLU n 
1 391 ARG n 
1 392 LEU n 
1 393 SER n 
1 394 ARG n 
1 395 MET n 
1 396 ALA n 
1 397 ILE n 
1 398 SER n 
1 399 GLY n 
1 400 ASP n 
1 401 ASP n 
1 402 CYS n 
1 403 VAL n 
1 404 VAL n 
1 405 LYS n 
1 406 PRO n 
1 407 LEU n 
1 408 ASP n 
1 409 ASP n 
1 410 ARG n 
1 411 PHE n 
1 412 ALA n 
1 413 SER n 
1 414 ALA n 
1 415 LEU n 
1 416 THR n 
1 417 ALA n 
1 418 LEU n 
1 419 ASN n 
1 420 ASP n 
1 421 MET n 
1 422 GLY n 
1 423 LYS n 
1 424 VAL n 
1 425 ARG n 
1 426 LYS n 
1 427 ASP n 
1 428 ILE n 
1 429 GLN n 
1 430 GLN n 
1 431 TRP n 
1 432 GLU n 
1 433 PRO n 
1 434 SER n 
1 435 ARG n 
1 436 GLY n 
1 437 TRP n 
1 438 ASN n 
1 439 ASP n 
1 440 TRP n 
1 441 THR n 
1 442 GLN n 
1 443 VAL n 
1 444 PRO n 
1 445 PHE n 
1 446 CYS n 
1 447 SER n 
1 448 HIS n 
1 449 HIS n 
1 450 PHE n 
1 451 HIS n 
1 452 GLU n 
1 453 LEU n 
1 454 ILE n 
1 455 MET n 
1 456 LYS n 
1 457 ASP n 
1 458 GLY n 
1 459 ARG n 
1 460 VAL n 
1 461 LEU n 
1 462 VAL n 
1 463 VAL n 
1 464 PRO n 
1 465 CYS n 
1 466 ARG n 
1 467 ASN n 
1 468 GLN n 
1 469 ASP n 
1 470 GLU n 
1 471 LEU n 
1 472 ILE n 
1 473 GLY n 
1 474 ARG n 
1 475 ALA n 
1 476 ARG n 
1 477 ILE n 
1 478 SER n 
1 479 GLN n 
1 480 GLY n 
1 481 ALA n 
1 482 GLY n 
1 483 TRP n 
1 484 SER n 
1 485 LEU n 
1 486 ARG n 
1 487 GLU n 
1 488 THR n 
1 489 ALA n 
1 490 CYS n 
1 491 LEU n 
1 492 GLY n 
1 493 LYS n 
1 494 SER n 
1 495 TYR n 
1 496 ALA n 
1 497 GLN n 
1 498 MET n 
1 499 TRP n 
1 500 SER n 
1 501 LEU n 
1 502 MET n 
1 503 TYR n 
1 504 PHE n 
1 505 HIS n 
1 506 ARG n 
1 507 ARG n 
1 508 ASP n 
1 509 LEU n 
1 510 ARG n 
1 511 LEU n 
1 512 ALA n 
1 513 ALA n 
1 514 ASN n 
1 515 ALA n 
1 516 ILE n 
1 517 CYS n 
1 518 SER n 
1 519 ALA n 
1 520 VAL n 
1 521 PRO n 
1 522 SER n 
1 523 HIS n 
1 524 TRP n 
1 525 VAL n 
1 526 PRO n 
1 527 THR n 
1 528 SER n 
1 529 ARG n 
1 530 THR n 
1 531 THR n 
1 532 TRP n 
1 533 SER n 
1 534 ILE n 
1 535 HIS n 
1 536 ALA n 
1 537 THR n 
1 538 HIS n 
1 539 GLU n 
1 540 TRP n 
1 541 MET n 
1 542 THR n 
1 543 THR n 
1 544 GLU n 
1 545 ASP n 
1 546 MET n 
1 547 LEU n 
1 548 THR n 
1 549 VAL n 
1 550 TRP n 
1 551 ASN n 
1 552 ARG n 
1 553 VAL n 
1 554 TRP n 
1 555 ILE n 
1 556 GLN n 
1 557 GLU n 
1 558 ASN n 
1 559 PRO n 
1 560 TRP n 
1 561 MET n 
1 562 GLU n 
1 563 ASP n 
1 564 LYS n 
1 565 THR n 
1 566 PRO n 
1 567 VAL n 
1 568 GLU n 
1 569 SER n 
1 570 TRP n 
1 571 GLU n 
1 572 GLU n 
1 573 ILE n 
1 574 PRO n 
1 575 TYR n 
1 576 LEU n 
1 577 GLY n 
1 578 LYS n 
1 579 ARG n 
1 580 GLU n 
1 581 ASP n 
1 582 GLN n 
1 583 TRP n 
1 584 CYS n 
1 585 GLY n 
1 586 SER n 
1 587 LEU n 
1 588 ILE n 
1 589 GLY n 
1 590 LEU n 
1 591 THR n 
1 592 SER n 
1 593 ARG n 
1 594 ALA n 
1 595 THR n 
1 596 TRP n 
1 597 ALA n 
1 598 LYS n 
1 599 ASN n 
1 600 ILE n 
1 601 GLN n 
1 602 THR n 
1 603 ALA n 
1 604 ILE n 
1 605 ASN n 
1 606 GLN n 
1 607 VAL n 
1 608 ARG n 
1 609 SER n 
1 610 LEU n 
1 611 ILE n 
1 612 GLY n 
1 613 ASN n 
1 614 GLU n 
1 615 GLU n 
1 616 TYR n 
1 617 THR n 
1 618 ASP n 
1 619 TYR n 
1 620 MET n 
1 621 PRO n 
1 622 SER n 
1 623 MET n 
1 624 LYS n 
1 625 ARG n 
1 626 PHE n 
1 627 ARG n 
1 628 ARG n 
1 629 GLU n 
1 630 GLU n 
1 631 GLU n 
1 632 GLU n 
1 633 ALA n 
1 634 GLY n 
1 635 VAL n 
1 636 LEU n 
1 637 TRP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   637 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'dengue virus type 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     11060 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                       ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                      ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                    ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                               ? 'C4 H7 N O4'     133.103 
CL  non-polymer         . 'CHLORIDE ION'                                ? 'Cl -1'          35.453  
CYS 'L-peptide linking' y CYSTEINE                                      ? 'C3 H7 N O2 S'   121.158 
DMS non-polymer         . 'DIMETHYL SULFOXIDE'                          ? 'C2 H6 O S'      78.133  
GLN 'L-peptide linking' y GLUTAMINE                                     ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                               ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                       ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                     ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                         ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                    ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                       ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                        ? 'C6 H15 N2 O2 1' 147.195 
MES non-polymer         . '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'        ? 'C6 H13 N O4 S'  195.237 
MET 'L-peptide linking' y METHIONINE                                    ? 'C5 H11 N O2 S'  149.211 
NW4 non-polymer         . '3-cyclohexyl-1-(morpholin-4-yl)propan-1-one' ? 'C13 H23 N O2'   225.327 
PEG non-polymer         . 'DI(HYDROXYETHYL)ETHER'                       ? 'C4 H10 O3'      106.120 
PHE 'L-peptide linking' y PHENYLALANINE                                 ? 'C9 H11 N O2'    165.189 
PO4 non-polymer         . 'PHOSPHATE ION'                               ? 'O4 P -3'        94.971  
PRO 'L-peptide linking' y PROLINE                                       ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                        ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                     ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                    ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                      ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                                        ? 'C5 H11 N O2'    117.146 
ZN  non-polymer         . 'ZINC ION'                                    ? 'Zn 2'           65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   264 ?   ?   ?   A . n 
A 1 2   PRO 2   265 ?   ?   ?   A . n 
A 1 3   GLY 3   266 ?   ?   ?   A . n 
A 1 4   ILE 4   267 ?   ?   ?   A . n 
A 1 5   GLU 5   268 ?   ?   ?   A . n 
A 1 6   SER 6   269 ?   ?   ?   A . n 
A 1 7   GLU 7   270 ?   ?   ?   A . n 
A 1 8   THR 8   271 ?   ?   ?   A . n 
A 1 9   PRO 9   272 ?   ?   ?   A . n 
A 1 10  ASN 10  273 273 ASN ASN A . n 
A 1 11  LEU 11  274 274 LEU LEU A . n 
A 1 12  ASP 12  275 275 ASP ASP A . n 
A 1 13  ILE 13  276 276 ILE ILE A . n 
A 1 14  ILE 14  277 277 ILE ILE A . n 
A 1 15  GLY 15  278 278 GLY GLY A . n 
A 1 16  LYS 16  279 279 LYS LYS A . n 
A 1 17  ARG 17  280 280 ARG ARG A . n 
A 1 18  ILE 18  281 281 ILE ILE A . n 
A 1 19  GLU 19  282 282 GLU GLU A . n 
A 1 20  LYS 20  283 283 LYS LYS A . n 
A 1 21  ILE 21  284 284 ILE ILE A . n 
A 1 22  LYS 22  285 285 LYS LYS A . n 
A 1 23  GLN 23  286 286 GLN GLN A . n 
A 1 24  GLU 24  287 287 GLU GLU A . n 
A 1 25  HIS 25  288 288 HIS HIS A . n 
A 1 26  GLU 26  289 289 GLU GLU A . n 
A 1 27  THR 27  290 290 THR THR A . n 
A 1 28  SER 28  291 291 SER SER A . n 
A 1 29  TRP 29  292 292 TRP TRP A . n 
A 1 30  HIS 30  293 293 HIS HIS A . n 
A 1 31  TYR 31  294 294 TYR TYR A . n 
A 1 32  ASP 32  295 295 ASP ASP A . n 
A 1 33  GLN 33  296 296 GLN GLN A . n 
A 1 34  ASP 34  297 297 ASP ASP A . n 
A 1 35  HIS 35  298 298 HIS HIS A . n 
A 1 36  PRO 36  299 299 PRO PRO A . n 
A 1 37  TYR 37  300 300 TYR TYR A . n 
A 1 38  LYS 38  301 301 LYS LYS A . n 
A 1 39  THR 39  302 302 THR THR A . n 
A 1 40  TRP 40  303 303 TRP TRP A . n 
A 1 41  ALA 41  304 304 ALA ALA A . n 
A 1 42  TYR 42  305 305 TYR TYR A . n 
A 1 43  HIS 43  306 306 HIS HIS A . n 
A 1 44  GLY 44  307 307 GLY GLY A . n 
A 1 45  SER 45  308 308 SER SER A . n 
A 1 46  TYR 46  309 309 TYR TYR A . n 
A 1 47  GLU 47  310 310 GLU GLU A . n 
A 1 48  THR 48  311 311 THR THR A . n 
A 1 49  LYS 49  312 312 LYS LYS A . n 
A 1 50  GLN 50  313 313 GLN GLN A . n 
A 1 51  THR 51  314 314 THR THR A . n 
A 1 52  GLY 52  315 ?   ?   ?   A . n 
A 1 53  SER 53  316 ?   ?   ?   A . n 
A 1 54  ALA 54  317 317 ALA ALA A . n 
A 1 55  SER 55  318 318 SER SER A . n 
A 1 56  SER 56  319 319 SER SER A . n 
A 1 57  MET 57  320 320 MET MET A . n 
A 1 58  VAL 58  321 321 VAL VAL A . n 
A 1 59  ASN 59  322 322 ASN ASN A . n 
A 1 60  GLY 60  323 323 GLY GLY A . n 
A 1 61  VAL 61  324 324 VAL VAL A . n 
A 1 62  VAL 62  325 325 VAL VAL A . n 
A 1 63  ARG 63  326 326 ARG ARG A . n 
A 1 64  LEU 64  327 327 LEU LEU A . n 
A 1 65  LEU 65  328 328 LEU LEU A . n 
A 1 66  THR 66  329 329 THR THR A . n 
A 1 67  LYS 67  330 330 LYS LYS A . n 
A 1 68  PRO 68  331 331 PRO PRO A . n 
A 1 69  TRP 69  332 332 TRP TRP A . n 
A 1 70  ASP 70  333 333 ASP ASP A . n 
A 1 71  ILE 71  334 334 ILE ILE A . n 
A 1 72  ILE 72  335 335 ILE ILE A . n 
A 1 73  PRO 73  336 336 PRO PRO A . n 
A 1 74  MET 74  337 337 MET MET A . n 
A 1 75  VAL 75  338 338 VAL VAL A . n 
A 1 76  THR 76  339 339 THR THR A . n 
A 1 77  GLN 77  340 340 GLN GLN A . n 
A 1 78  MET 78  341 341 MET MET A . n 
A 1 79  ALA 79  342 342 ALA ALA A . n 
A 1 80  MET 80  343 343 MET MET A . n 
A 1 81  THR 81  344 344 THR GLY A . n 
A 1 82  ASP 82  345 ?   ?   ?   A . n 
A 1 83  THR 83  346 ?   ?   ?   A . n 
A 1 84  THR 84  347 ?   ?   ?   A . n 
A 1 85  PRO 85  348 ?   ?   ?   A . n 
A 1 86  PHE 86  349 ?   ?   ?   A . n 
A 1 87  GLY 87  350 ?   ?   ?   A . n 
A 1 88  GLN 88  351 ?   ?   ?   A . n 
A 1 89  GLN 89  352 ?   ?   ?   A . n 
A 1 90  ARG 90  353 ?   ?   ?   A . n 
A 1 91  VAL 91  354 ?   ?   ?   A . n 
A 1 92  PHE 92  355 ?   ?   ?   A . n 
A 1 93  LYS 93  356 356 LYS LYS A . n 
A 1 94  GLU 94  357 357 GLU GLU A . n 
A 1 95  LYS 95  358 358 LYS LYS A . n 
A 1 96  VAL 96  359 359 VAL VAL A . n 
A 1 97  ASP 97  360 360 ASP ASP A . n 
A 1 98  THR 98  361 361 THR THR A . n 
A 1 99  ARG 99  362 362 ARG ARG A . n 
A 1 100 THR 100 363 363 THR THR A . n 
A 1 101 GLN 101 364 364 GLN GLN A . n 
A 1 102 GLU 102 365 365 GLU GLU A . n 
A 1 103 PRO 103 366 366 PRO PRO A . n 
A 1 104 LYS 104 367 367 LYS LYS A . n 
A 1 105 GLU 105 368 368 GLU GLU A . n 
A 1 106 GLY 106 369 369 GLY GLY A . n 
A 1 107 THR 107 370 370 THR THR A . n 
A 1 108 LYS 108 371 371 LYS LYS A . n 
A 1 109 LYS 109 372 372 LYS LYS A . n 
A 1 110 LEU 110 373 373 LEU LEU A . n 
A 1 111 MET 111 374 374 MET MET A . n 
A 1 112 LYS 112 375 375 LYS LYS A . n 
A 1 113 ILE 113 376 376 ILE ILE A . n 
A 1 114 THR 114 377 377 THR THR A . n 
A 1 115 ALA 115 378 378 ALA ALA A . n 
A 1 116 GLU 116 379 379 GLU GLU A . n 
A 1 117 TRP 117 380 380 TRP TRP A . n 
A 1 118 LEU 118 381 381 LEU LEU A . n 
A 1 119 TRP 119 382 382 TRP TRP A . n 
A 1 120 LYS 120 383 383 LYS LYS A . n 
A 1 121 GLU 121 384 384 GLU GLU A . n 
A 1 122 LEU 122 385 385 LEU LEU A . n 
A 1 123 GLY 123 386 386 GLY GLY A . n 
A 1 124 LYS 124 387 387 LYS LYS A . n 
A 1 125 LYS 125 388 388 LYS LYS A . n 
A 1 126 LYS 126 389 389 LYS LYS A . n 
A 1 127 THR 127 390 390 THR THR A . n 
A 1 128 PRO 128 391 391 PRO PRO A . n 
A 1 129 ARG 129 392 392 ARG ARG A . n 
A 1 130 MET 130 393 393 MET MET A . n 
A 1 131 CYS 131 394 394 CYS CYS A . n 
A 1 132 THR 132 395 395 THR THR A . n 
A 1 133 ARG 133 396 396 ARG ARG A . n 
A 1 134 GLU 134 397 397 GLU GLU A . n 
A 1 135 GLU 135 398 398 GLU GLU A . n 
A 1 136 PHE 136 399 399 PHE PHE A . n 
A 1 137 THR 137 400 400 THR THR A . n 
A 1 138 ARG 138 401 401 ARG ARG A . n 
A 1 139 LYS 139 402 402 LYS LYS A . n 
A 1 140 VAL 140 403 403 VAL VAL A . n 
A 1 141 ARG 141 404 404 ARG ARG A . n 
A 1 142 SER 142 405 405 SER SER A . n 
A 1 143 ASN 143 406 406 ASN ASN A . n 
A 1 144 ALA 144 407 407 ALA ALA A . n 
A 1 145 ALA 145 408 408 ALA ALA A . n 
A 1 146 LEU 146 409 409 LEU LEU A . n 
A 1 147 GLY 147 410 410 GLY GLY A . n 
A 1 148 ALA 148 411 411 ALA ALA A . n 
A 1 149 ILE 149 412 412 ILE ILE A . n 
A 1 150 PHE 150 413 ?   ?   ?   A . n 
A 1 151 THR 151 414 ?   ?   ?   A . n 
A 1 152 ASP 152 415 ?   ?   ?   A . n 
A 1 153 GLU 153 416 ?   ?   ?   A . n 
A 1 154 ASN 154 417 ?   ?   ?   A . n 
A 1 155 LYS 155 418 ?   ?   ?   A . n 
A 1 156 TRP 156 419 419 TRP TRP A . n 
A 1 157 LYS 157 420 420 LYS LYS A . n 
A 1 158 SER 158 421 421 SER SER A . n 
A 1 159 ALA 159 422 422 ALA ALA A . n 
A 1 160 ARG 160 423 423 ARG ARG A . n 
A 1 161 GLU 161 424 424 GLU GLU A . n 
A 1 162 ALA 162 425 425 ALA ALA A . n 
A 1 163 VAL 163 426 426 VAL VAL A . n 
A 1 164 GLU 164 427 427 GLU GLU A . n 
A 1 165 ASP 165 428 428 ASP ASP A . n 
A 1 166 SER 166 429 429 SER SER A . n 
A 1 167 GLY 167 430 430 GLY GLY A . n 
A 1 168 PHE 168 431 431 PHE PHE A . n 
A 1 169 TRP 169 432 432 TRP TRP A . n 
A 1 170 GLU 170 433 433 GLU GLU A . n 
A 1 171 LEU 171 434 434 LEU LEU A . n 
A 1 172 VAL 172 435 435 VAL VAL A . n 
A 1 173 ASP 173 436 436 ASP ASP A . n 
A 1 174 LYS 174 437 437 LYS LYS A . n 
A 1 175 GLU 175 438 438 GLU GLU A . n 
A 1 176 ARG 176 439 439 ARG ARG A . n 
A 1 177 ASN 177 440 440 ASN ASN A . n 
A 1 178 LEU 178 441 441 LEU LEU A . n 
A 1 179 HIS 179 442 442 HIS HIS A . n 
A 1 180 LEU 180 443 443 LEU LEU A . n 
A 1 181 GLU 181 444 444 GLU GLU A . n 
A 1 182 GLY 182 445 445 GLY GLY A . n 
A 1 183 LYS 183 446 446 LYS LYS A . n 
A 1 184 CYS 184 447 447 CYS CYS A . n 
A 1 185 GLU 185 448 448 GLU GLU A . n 
A 1 186 THR 186 449 449 THR THR A . n 
A 1 187 CYS 187 450 450 CYS CYS A . n 
A 1 188 VAL 188 451 451 VAL VAL A . n 
A 1 189 TYR 189 452 452 TYR TYR A . n 
A 1 190 ASN 190 453 453 ASN ASN A . n 
A 1 191 MET 191 454 454 MET MET A . n 
A 1 192 MET 192 455 455 MET MET A . n 
A 1 193 GLY 193 456 ?   ?   ?   A . n 
A 1 194 LYS 194 457 ?   ?   ?   A . n 
A 1 195 ARG 195 458 ?   ?   ?   A . n 
A 1 196 GLU 196 459 ?   ?   ?   A . n 
A 1 197 LYS 197 460 ?   ?   ?   A . n 
A 1 198 LYS 198 461 ?   ?   ?   A . n 
A 1 199 LEU 199 462 ?   ?   ?   A . n 
A 1 200 GLY 200 463 ?   ?   ?   A . n 
A 1 201 GLU 201 464 ?   ?   ?   A . n 
A 1 202 PHE 202 465 ?   ?   ?   A . n 
A 1 203 GLY 203 466 ?   ?   ?   A . n 
A 1 204 LYS 204 467 ?   ?   ?   A . n 
A 1 205 ALA 205 468 ?   ?   ?   A . n 
A 1 206 LYS 206 469 ?   ?   ?   A . n 
A 1 207 GLY 207 470 ?   ?   ?   A . n 
A 1 208 SER 208 471 ?   ?   ?   A . n 
A 1 209 ARG 209 472 ?   ?   ?   A . n 
A 1 210 ALA 210 473 473 ALA ALA A . n 
A 1 211 ILE 211 474 474 ILE ILE A . n 
A 1 212 TRP 212 475 475 TRP TRP A . n 
A 1 213 TYR 213 476 476 TYR TYR A . n 
A 1 214 MET 214 477 477 MET MET A . n 
A 1 215 TRP 215 478 478 TRP TRP A . n 
A 1 216 LEU 216 479 479 LEU LEU A . n 
A 1 217 GLY 217 480 480 GLY GLY A . n 
A 1 218 ALA 218 481 481 ALA ALA A . n 
A 1 219 ARG 219 482 482 ARG ARG A . n 
A 1 220 PHE 220 483 483 PHE PHE A . n 
A 1 221 LEU 221 484 484 LEU LEU A . n 
A 1 222 GLU 222 485 485 GLU GLU A . n 
A 1 223 PHE 223 486 486 PHE PHE A . n 
A 1 224 GLU 224 487 487 GLU GLU A . n 
A 1 225 ALA 225 488 488 ALA ALA A . n 
A 1 226 LEU 226 489 489 LEU LEU A . n 
A 1 227 GLY 227 490 490 GLY GLY A . n 
A 1 228 PHE 228 491 491 PHE PHE A . n 
A 1 229 LEU 229 492 492 LEU LEU A . n 
A 1 230 ASN 230 493 493 ASN ASN A . n 
A 1 231 GLU 231 494 494 GLU GLU A . n 
A 1 232 ASP 232 495 495 ASP ASP A . n 
A 1 233 HIS 233 496 496 HIS HIS A . n 
A 1 234 TRP 234 497 497 TRP TRP A . n 
A 1 235 PHE 235 498 498 PHE PHE A . n 
A 1 236 SER 236 499 499 SER SER A . n 
A 1 237 ARG 237 500 500 ARG ARG A . n 
A 1 238 GLU 238 501 501 GLU GLU A . n 
A 1 239 ASN 239 502 502 ASN ASN A . n 
A 1 240 SER 240 503 503 SER SER A . n 
A 1 241 LEU 241 504 504 LEU LEU A . n 
A 1 242 SER 242 505 505 SER SER A . n 
A 1 243 GLY 243 506 506 GLY GLY A . n 
A 1 244 VAL 244 507 507 VAL VAL A . n 
A 1 245 GLU 245 508 508 GLU GLU A . n 
A 1 246 GLY 246 509 509 GLY GLY A . n 
A 1 247 GLU 247 510 510 GLU GLU A . n 
A 1 248 GLY 248 511 511 GLY GLY A . n 
A 1 249 LEU 249 512 512 LEU LEU A . n 
A 1 250 HIS 250 513 513 HIS HIS A . n 
A 1 251 LYS 251 514 514 LYS LYS A . n 
A 1 252 LEU 252 515 515 LEU LEU A . n 
A 1 253 GLY 253 516 516 GLY GLY A . n 
A 1 254 TYR 254 517 517 TYR TYR A . n 
A 1 255 ILE 255 518 518 ILE ILE A . n 
A 1 256 LEU 256 519 519 LEU LEU A . n 
A 1 257 ARG 257 520 520 ARG ARG A . n 
A 1 258 ASP 258 521 521 ASP ASP A . n 
A 1 259 VAL 259 522 522 VAL VAL A . n 
A 1 260 SER 260 523 523 SER SER A . n 
A 1 261 LYS 261 524 524 LYS LYS A . n 
A 1 262 LYS 262 525 525 LYS LYS A . n 
A 1 263 GLU 263 526 526 GLU GLU A . n 
A 1 264 GLY 264 527 527 GLY GLY A . n 
A 1 265 GLY 265 528 528 GLY GLY A . n 
A 1 266 ALA 266 529 529 ALA ALA A . n 
A 1 267 MET 267 530 530 MET MET A . n 
A 1 268 TYR 268 531 531 TYR TYR A . n 
A 1 269 ALA 269 532 532 ALA ALA A . n 
A 1 270 ASP 270 533 533 ASP ASP A . n 
A 1 271 ASP 271 534 534 ASP ASP A . n 
A 1 272 THR 272 535 535 THR THR A . n 
A 1 273 ALA 273 536 536 ALA ALA A . n 
A 1 274 GLY 274 537 537 GLY GLY A . n 
A 1 275 TRP 275 538 538 TRP TRP A . n 
A 1 276 ASP 276 539 539 ASP ASP A . n 
A 1 277 THR 277 540 540 THR THR A . n 
A 1 278 ARG 278 541 541 ARG ARG A . n 
A 1 279 ILE 279 542 542 ILE ILE A . n 
A 1 280 THR 280 543 543 THR THR A . n 
A 1 281 LEU 281 544 544 LEU LEU A . n 
A 1 282 GLU 282 545 545 GLU GLU A . n 
A 1 283 ASP 283 546 546 ASP ASP A . n 
A 1 284 LEU 284 547 547 LEU LEU A . n 
A 1 285 LYS 285 548 548 LYS LYS A . n 
A 1 286 ASN 286 549 549 ASN ASN A . n 
A 1 287 GLU 287 550 550 GLU GLU A . n 
A 1 288 GLU 288 551 551 GLU GLU A . n 
A 1 289 MET 289 552 552 MET MET A . n 
A 1 290 VAL 290 553 553 VAL VAL A . n 
A 1 291 THR 291 554 554 THR THR A . n 
A 1 292 ASN 292 555 555 ASN ASN A . n 
A 1 293 HIS 293 556 556 HIS HIS A . n 
A 1 294 MET 294 557 557 MET MET A . n 
A 1 295 GLU 295 558 558 GLU GLU A . n 
A 1 296 GLY 296 559 559 GLY GLY A . n 
A 1 297 GLU 297 560 560 GLU GLU A . n 
A 1 298 HIS 298 561 561 HIS HIS A . n 
A 1 299 LYS 299 562 562 LYS LYS A . n 
A 1 300 LYS 300 563 563 LYS LYS A . n 
A 1 301 LEU 301 564 564 LEU LEU A . n 
A 1 302 ALA 302 565 565 ALA ALA A . n 
A 1 303 GLU 303 566 566 GLU GLU A . n 
A 1 304 ALA 304 567 567 ALA ALA A . n 
A 1 305 ILE 305 568 568 ILE ILE A . n 
A 1 306 PHE 306 569 569 PHE PHE A . n 
A 1 307 LYS 307 570 570 LYS LYS A . n 
A 1 308 LEU 308 571 571 LEU LEU A . n 
A 1 309 THR 309 572 572 THR THR A . n 
A 1 310 TYR 310 573 573 TYR TYR A . n 
A 1 311 GLN 311 574 574 GLN GLN A . n 
A 1 312 ASN 312 575 575 ASN ASN A . n 
A 1 313 LYS 313 576 576 LYS LYS A . n 
A 1 314 VAL 314 577 577 VAL VAL A . n 
A 1 315 VAL 315 578 578 VAL VAL A . n 
A 1 316 ARG 316 579 579 ARG ARG A . n 
A 1 317 VAL 317 580 580 VAL VAL A . n 
A 1 318 GLN 318 581 581 GLN GLN A . n 
A 1 319 ARG 319 582 582 ARG ARG A . n 
A 1 320 PRO 320 583 583 PRO PRO A . n 
A 1 321 THR 321 584 584 THR THR A . n 
A 1 322 PRO 322 585 ?   ?   ?   A . n 
A 1 323 ARG 323 586 ?   ?   ?   A . n 
A 1 324 GLY 324 587 ?   ?   ?   A . n 
A 1 325 THR 325 588 588 THR THR A . n 
A 1 326 VAL 326 589 589 VAL VAL A . n 
A 1 327 MET 327 590 590 MET MET A . n 
A 1 328 ASP 328 591 591 ASP ASP A . n 
A 1 329 ILE 329 592 592 ILE ILE A . n 
A 1 330 ILE 330 593 593 ILE ILE A . n 
A 1 331 SER 331 594 594 SER SER A . n 
A 1 332 ARG 332 595 595 ARG ARG A . n 
A 1 333 ARG 333 596 596 ARG ARG A . n 
A 1 334 ASP 334 597 597 ASP ASP A . n 
A 1 335 GLN 335 598 598 GLN GLN A . n 
A 1 336 ARG 336 599 599 ARG ARG A . n 
A 1 337 GLY 337 600 600 GLY GLY A . n 
A 1 338 SER 338 601 601 SER SER A . n 
A 1 339 GLY 339 602 602 GLY GLY A . n 
A 1 340 GLN 340 603 603 GLN GLN A . n 
A 1 341 VAL 341 604 604 VAL VAL A . n 
A 1 342 VAL 342 605 605 VAL VAL A . n 
A 1 343 THR 343 606 606 THR THR A . n 
A 1 344 TYR 344 607 607 TYR TYR A . n 
A 1 345 GLY 345 608 608 GLY GLY A . n 
A 1 346 LEU 346 609 609 LEU LEU A . n 
A 1 347 ASN 347 610 610 ASN ASN A . n 
A 1 348 THR 348 611 611 THR THR A . n 
A 1 349 PHE 349 612 612 PHE PHE A . n 
A 1 350 THR 350 613 613 THR THR A . n 
A 1 351 ASN 351 614 614 ASN ASN A . n 
A 1 352 MET 352 615 615 MET MET A . n 
A 1 353 GLU 353 616 616 GLU GLU A . n 
A 1 354 ALA 354 617 617 ALA ALA A . n 
A 1 355 GLN 355 618 618 GLN GLN A . n 
A 1 356 LEU 356 619 619 LEU LEU A . n 
A 1 357 ILE 357 620 620 ILE ILE A . n 
A 1 358 ARG 358 621 621 ARG ARG A . n 
A 1 359 GLN 359 622 622 GLN GLN A . n 
A 1 360 MET 360 623 623 MET MET A . n 
A 1 361 GLU 361 624 624 GLU GLU A . n 
A 1 362 GLY 362 625 625 GLY GLY A . n 
A 1 363 GLU 363 626 626 GLU GLU A . n 
A 1 364 GLY 364 627 627 GLY GLY A . n 
A 1 365 VAL 365 628 628 VAL VAL A . n 
A 1 366 PHE 366 629 629 PHE PHE A . n 
A 1 367 LYS 367 630 630 LYS LYS A . n 
A 1 368 SER 368 631 631 SER SER A . n 
A 1 369 ILE 369 632 632 ILE ILE A . n 
A 1 370 GLN 370 633 633 GLN GLN A . n 
A 1 371 HIS 371 634 634 HIS HIS A . n 
A 1 372 LEU 372 635 635 LEU LEU A . n 
A 1 373 THR 373 636 636 THR THR A . n 
A 1 374 VAL 374 637 637 VAL VAL A . n 
A 1 375 THR 375 638 638 THR THR A . n 
A 1 376 GLU 376 639 639 GLU GLU A . n 
A 1 377 GLU 377 640 640 GLU GLU A . n 
A 1 378 ILE 378 641 641 ILE ILE A . n 
A 1 379 ALA 379 642 642 ALA ALA A . n 
A 1 380 VAL 380 643 643 VAL VAL A . n 
A 1 381 LYS 381 644 644 LYS LYS A . n 
A 1 382 ASN 382 645 645 ASN ASN A . n 
A 1 383 TRP 383 646 646 TRP TRP A . n 
A 1 384 LEU 384 647 647 LEU LEU A . n 
A 1 385 VAL 385 648 648 VAL VAL A . n 
A 1 386 ARG 386 649 649 ARG ARG A . n 
A 1 387 VAL 387 650 650 VAL VAL A . n 
A 1 388 GLY 388 651 651 GLY GLY A . n 
A 1 389 ARG 389 652 652 ARG ARG A . n 
A 1 390 GLU 390 653 653 GLU GLU A . n 
A 1 391 ARG 391 654 654 ARG ARG A . n 
A 1 392 LEU 392 655 655 LEU LEU A . n 
A 1 393 SER 393 656 656 SER SER A . n 
A 1 394 ARG 394 657 657 ARG ARG A . n 
A 1 395 MET 395 658 658 MET MET A . n 
A 1 396 ALA 396 659 659 ALA ALA A . n 
A 1 397 ILE 397 660 660 ILE ILE A . n 
A 1 398 SER 398 661 661 SER SER A . n 
A 1 399 GLY 399 662 662 GLY GLY A . n 
A 1 400 ASP 400 663 663 ASP ASP A . n 
A 1 401 ASP 401 664 664 ASP ASP A . n 
A 1 402 CYS 402 665 665 CYS CYS A . n 
A 1 403 VAL 403 666 666 VAL VAL A . n 
A 1 404 VAL 404 667 667 VAL VAL A . n 
A 1 405 LYS 405 668 668 LYS LYS A . n 
A 1 406 PRO 406 669 669 PRO PRO A . n 
A 1 407 LEU 407 670 670 LEU LEU A . n 
A 1 408 ASP 408 671 671 ASP ASP A . n 
A 1 409 ASP 409 672 672 ASP ASP A . n 
A 1 410 ARG 410 673 673 ARG ARG A . n 
A 1 411 PHE 411 674 674 PHE PHE A . n 
A 1 412 ALA 412 675 675 ALA ALA A . n 
A 1 413 SER 413 676 676 SER SER A . n 
A 1 414 ALA 414 677 677 ALA ALA A . n 
A 1 415 LEU 415 678 678 LEU LEU A . n 
A 1 416 THR 416 679 679 THR THR A . n 
A 1 417 ALA 417 680 680 ALA ALA A . n 
A 1 418 LEU 418 681 681 LEU LEU A . n 
A 1 419 ASN 419 682 682 ASN ASN A . n 
A 1 420 ASP 420 683 683 ASP ASP A . n 
A 1 421 MET 421 684 684 MET MET A . n 
A 1 422 GLY 422 685 685 GLY GLY A . n 
A 1 423 LYS 423 686 686 LYS LYS A . n 
A 1 424 VAL 424 687 687 VAL VAL A . n 
A 1 425 ARG 425 688 688 ARG ARG A . n 
A 1 426 LYS 426 689 689 LYS LYS A . n 
A 1 427 ASP 427 690 690 ASP ASP A . n 
A 1 428 ILE 428 691 691 ILE ILE A . n 
A 1 429 GLN 429 692 692 GLN GLN A . n 
A 1 430 GLN 430 693 693 GLN GLN A . n 
A 1 431 TRP 431 694 694 TRP TRP A . n 
A 1 432 GLU 432 695 695 GLU GLU A . n 
A 1 433 PRO 433 696 696 PRO PRO A . n 
A 1 434 SER 434 697 697 SER SER A . n 
A 1 435 ARG 435 698 698 ARG ARG A . n 
A 1 436 GLY 436 699 699 GLY GLY A . n 
A 1 437 TRP 437 700 700 TRP TRP A . n 
A 1 438 ASN 438 701 701 ASN ASN A . n 
A 1 439 ASP 439 702 702 ASP ASP A . n 
A 1 440 TRP 440 703 703 TRP TRP A . n 
A 1 441 THR 441 704 704 THR THR A . n 
A 1 442 GLN 442 705 705 GLN GLN A . n 
A 1 443 VAL 443 706 706 VAL VAL A . n 
A 1 444 PRO 444 707 707 PRO PRO A . n 
A 1 445 PHE 445 708 708 PHE PHE A . n 
A 1 446 CYS 446 709 709 CYS CYS A . n 
A 1 447 SER 447 710 710 SER SER A . n 
A 1 448 HIS 448 711 711 HIS HIS A . n 
A 1 449 HIS 449 712 712 HIS HIS A . n 
A 1 450 PHE 450 713 713 PHE PHE A . n 
A 1 451 HIS 451 714 714 HIS HIS A . n 
A 1 452 GLU 452 715 715 GLU GLU A . n 
A 1 453 LEU 453 716 716 LEU LEU A . n 
A 1 454 ILE 454 717 717 ILE ILE A . n 
A 1 455 MET 455 718 718 MET MET A . n 
A 1 456 LYS 456 719 719 LYS LYS A . n 
A 1 457 ASP 457 720 720 ASP ASP A . n 
A 1 458 GLY 458 721 721 GLY GLY A . n 
A 1 459 ARG 459 722 722 ARG ARG A . n 
A 1 460 VAL 460 723 723 VAL VAL A . n 
A 1 461 LEU 461 724 724 LEU LEU A . n 
A 1 462 VAL 462 725 725 VAL VAL A . n 
A 1 463 VAL 463 726 726 VAL VAL A . n 
A 1 464 PRO 464 727 727 PRO PRO A . n 
A 1 465 CYS 465 728 728 CYS CYS A . n 
A 1 466 ARG 466 729 729 ARG ARG A . n 
A 1 467 ASN 467 730 730 ASN ASN A . n 
A 1 468 GLN 468 731 731 GLN GLN A . n 
A 1 469 ASP 469 732 732 ASP ASP A . n 
A 1 470 GLU 470 733 733 GLU GLU A . n 
A 1 471 LEU 471 734 734 LEU LEU A . n 
A 1 472 ILE 472 735 735 ILE ILE A . n 
A 1 473 GLY 473 736 736 GLY GLY A . n 
A 1 474 ARG 474 737 737 ARG ARG A . n 
A 1 475 ALA 475 738 738 ALA ALA A . n 
A 1 476 ARG 476 739 739 ARG ARG A . n 
A 1 477 ILE 477 740 740 ILE ILE A . n 
A 1 478 SER 478 741 741 SER SER A . n 
A 1 479 GLN 479 742 742 GLN GLN A . n 
A 1 480 GLY 480 743 743 GLY GLY A . n 
A 1 481 ALA 481 744 744 ALA ALA A . n 
A 1 482 GLY 482 745 745 GLY GLY A . n 
A 1 483 TRP 483 746 746 TRP TRP A . n 
A 1 484 SER 484 747 747 SER SER A . n 
A 1 485 LEU 485 748 748 LEU LEU A . n 
A 1 486 ARG 486 749 749 ARG ARG A . n 
A 1 487 GLU 487 750 750 GLU GLU A . n 
A 1 488 THR 488 751 751 THR THR A . n 
A 1 489 ALA 489 752 752 ALA ALA A . n 
A 1 490 CYS 490 753 753 CYS CYS A . n 
A 1 491 LEU 491 754 754 LEU LEU A . n 
A 1 492 GLY 492 755 755 GLY GLY A . n 
A 1 493 LYS 493 756 756 LYS LYS A . n 
A 1 494 SER 494 757 757 SER SER A . n 
A 1 495 TYR 495 758 758 TYR TYR A . n 
A 1 496 ALA 496 759 759 ALA ALA A . n 
A 1 497 GLN 497 760 760 GLN GLN A . n 
A 1 498 MET 498 761 761 MET MET A . n 
A 1 499 TRP 499 762 762 TRP TRP A . n 
A 1 500 SER 500 763 763 SER SER A . n 
A 1 501 LEU 501 764 764 LEU LEU A . n 
A 1 502 MET 502 765 765 MET MET A . n 
A 1 503 TYR 503 766 766 TYR TYR A . n 
A 1 504 PHE 504 767 767 PHE PHE A . n 
A 1 505 HIS 505 768 768 HIS HIS A . n 
A 1 506 ARG 506 769 769 ARG ARG A . n 
A 1 507 ARG 507 770 770 ARG ARG A . n 
A 1 508 ASP 508 771 771 ASP ASP A . n 
A 1 509 LEU 509 772 772 LEU LEU A . n 
A 1 510 ARG 510 773 773 ARG ARG A . n 
A 1 511 LEU 511 774 774 LEU LEU A . n 
A 1 512 ALA 512 775 775 ALA ALA A . n 
A 1 513 ALA 513 776 776 ALA ALA A . n 
A 1 514 ASN 514 777 777 ASN ASN A . n 
A 1 515 ALA 515 778 778 ALA ALA A . n 
A 1 516 ILE 516 779 779 ILE ILE A . n 
A 1 517 CYS 517 780 780 CYS CYS A . n 
A 1 518 SER 518 781 781 SER SER A . n 
A 1 519 ALA 519 782 782 ALA ALA A . n 
A 1 520 VAL 520 783 783 VAL VAL A . n 
A 1 521 PRO 521 784 784 PRO PRO A . n 
A 1 522 SER 522 785 785 SER SER A . n 
A 1 523 HIS 523 786 786 HIS HIS A . n 
A 1 524 TRP 524 787 787 TRP TRP A . n 
A 1 525 VAL 525 788 788 VAL VAL A . n 
A 1 526 PRO 526 789 789 PRO PRO A . n 
A 1 527 THR 527 790 790 THR THR A . n 
A 1 528 SER 528 791 791 SER SER A . n 
A 1 529 ARG 529 792 792 ARG ARG A . n 
A 1 530 THR 530 793 793 THR THR A . n 
A 1 531 THR 531 794 794 THR THR A . n 
A 1 532 TRP 532 795 ?   ?   ?   A . n 
A 1 533 SER 533 796 ?   ?   ?   A . n 
A 1 534 ILE 534 797 ?   ?   ?   A . n 
A 1 535 HIS 535 798 ?   ?   ?   A . n 
A 1 536 ALA 536 799 799 ALA ALA A . n 
A 1 537 THR 537 800 800 THR THR A . n 
A 1 538 HIS 538 801 801 HIS HIS A . n 
A 1 539 GLU 539 802 802 GLU GLU A . n 
A 1 540 TRP 540 803 803 TRP TRP A . n 
A 1 541 MET 541 804 804 MET MET A . n 
A 1 542 THR 542 805 805 THR THR A . n 
A 1 543 THR 543 806 806 THR THR A . n 
A 1 544 GLU 544 807 807 GLU GLU A . n 
A 1 545 ASP 545 808 808 ASP ASP A . n 
A 1 546 MET 546 809 809 MET MET A . n 
A 1 547 LEU 547 810 810 LEU LEU A . n 
A 1 548 THR 548 811 811 THR THR A . n 
A 1 549 VAL 549 812 812 VAL VAL A . n 
A 1 550 TRP 550 813 813 TRP TRP A . n 
A 1 551 ASN 551 814 814 ASN ASN A . n 
A 1 552 ARG 552 815 815 ARG ARG A . n 
A 1 553 VAL 553 816 816 VAL VAL A . n 
A 1 554 TRP 554 817 817 TRP TRP A . n 
A 1 555 ILE 555 818 818 ILE ILE A . n 
A 1 556 GLN 556 819 819 GLN GLN A . n 
A 1 557 GLU 557 820 820 GLU GLU A . n 
A 1 558 ASN 558 821 821 ASN ASN A . n 
A 1 559 PRO 559 822 822 PRO PRO A . n 
A 1 560 TRP 560 823 823 TRP TRP A . n 
A 1 561 MET 561 824 824 MET MET A . n 
A 1 562 GLU 562 825 825 GLU GLU A . n 
A 1 563 ASP 563 826 826 ASP ASP A . n 
A 1 564 LYS 564 827 827 LYS LYS A . n 
A 1 565 THR 565 828 828 THR THR A . n 
A 1 566 PRO 566 829 829 PRO PRO A . n 
A 1 567 VAL 567 830 830 VAL VAL A . n 
A 1 568 GLU 568 831 831 GLU GLU A . n 
A 1 569 SER 569 832 832 SER SER A . n 
A 1 570 TRP 570 833 833 TRP TRP A . n 
A 1 571 GLU 571 834 834 GLU GLU A . n 
A 1 572 GLU 572 835 835 GLU GLU A . n 
A 1 573 ILE 573 836 836 ILE ILE A . n 
A 1 574 PRO 574 837 837 PRO PRO A . n 
A 1 575 TYR 575 838 838 TYR TYR A . n 
A 1 576 LEU 576 839 839 LEU LEU A . n 
A 1 577 GLY 577 840 840 GLY GLY A . n 
A 1 578 LYS 578 841 841 LYS LYS A . n 
A 1 579 ARG 579 842 842 ARG ARG A . n 
A 1 580 GLU 580 843 843 GLU GLU A . n 
A 1 581 ASP 581 844 844 ASP ASP A . n 
A 1 582 GLN 582 845 845 GLN GLN A . n 
A 1 583 TRP 583 846 846 TRP TRP A . n 
A 1 584 CYS 584 847 847 CYS CYS A . n 
A 1 585 GLY 585 848 848 GLY GLY A . n 
A 1 586 SER 586 849 849 SER SER A . n 
A 1 587 LEU 587 850 850 LEU LEU A . n 
A 1 588 ILE 588 851 851 ILE ILE A . n 
A 1 589 GLY 589 852 852 GLY GLY A . n 
A 1 590 LEU 590 853 853 LEU LEU A . n 
A 1 591 THR 591 854 854 THR THR A . n 
A 1 592 SER 592 855 855 SER SER A . n 
A 1 593 ARG 593 856 856 ARG ARG A . n 
A 1 594 ALA 594 857 857 ALA ALA A . n 
A 1 595 THR 595 858 858 THR THR A . n 
A 1 596 TRP 596 859 859 TRP TRP A . n 
A 1 597 ALA 597 860 860 ALA ALA A . n 
A 1 598 LYS 598 861 861 LYS LYS A . n 
A 1 599 ASN 599 862 862 ASN ASN A . n 
A 1 600 ILE 600 863 863 ILE ILE A . n 
A 1 601 GLN 601 864 864 GLN GLN A . n 
A 1 602 THR 602 865 865 THR THR A . n 
A 1 603 ALA 603 866 866 ALA ALA A . n 
A 1 604 ILE 604 867 867 ILE ILE A . n 
A 1 605 ASN 605 868 868 ASN ASN A . n 
A 1 606 GLN 606 869 869 GLN GLN A . n 
A 1 607 VAL 607 870 870 VAL VAL A . n 
A 1 608 ARG 608 871 871 ARG ARG A . n 
A 1 609 SER 609 872 872 SER SER A . n 
A 1 610 LEU 610 873 873 LEU LEU A . n 
A 1 611 ILE 611 874 874 ILE ILE A . n 
A 1 612 GLY 612 875 875 GLY GLY A . n 
A 1 613 ASN 613 876 876 ASN ASN A . n 
A 1 614 GLU 614 877 877 GLU GLU A . n 
A 1 615 GLU 615 878 878 GLU GLU A . n 
A 1 616 TYR 616 879 879 TYR TYR A . n 
A 1 617 THR 617 880 880 THR THR A . n 
A 1 618 ASP 618 881 881 ASP ASP A . n 
A 1 619 TYR 619 882 882 TYR TYR A . n 
A 1 620 MET 620 883 883 MET MET A . n 
A 1 621 PRO 621 884 884 PRO PRO A . n 
A 1 622 SER 622 885 885 SER SER A . n 
A 1 623 MET 623 886 886 MET MET A . n 
A 1 624 LYS 624 887 887 LYS LYS A . n 
A 1 625 ARG 625 888 888 ARG ARG A . n 
A 1 626 PHE 626 889 889 PHE PHE A . n 
A 1 627 ARG 627 890 890 ARG ARG A . n 
A 1 628 ARG 628 891 891 ARG ARG A . n 
A 1 629 GLU 629 892 ?   ?   ?   A . n 
A 1 630 GLU 630 893 ?   ?   ?   A . n 
A 1 631 GLU 631 894 ?   ?   ?   A . n 
A 1 632 GLU 632 895 ?   ?   ?   A . n 
A 1 633 ALA 633 896 ?   ?   ?   A . n 
A 1 634 GLY 634 897 ?   ?   ?   A . n 
A 1 635 VAL 635 898 ?   ?   ?   A . n 
A 1 636 LEU 636 899 ?   ?   ?   A . n 
A 1 637 TRP 637 900 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        NW4 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   NW4 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 ZN  1   1001 1001 ZN  ZN  A . 
C 2 ZN  1   1002 1002 ZN  ZN  A . 
D 3 MES 1   1003 1004 MES MES A . 
E 4 DMS 1   1004 1530 DMS DMS A . 
F 4 DMS 1   1005 1601 DMS DMS A . 
G 4 DMS 1   1006 1602 DMS DMS A . 
H 5 PEG 1   1007 1603 PEG PEG A . 
I 6 PO4 1   1008 1604 PO4 PO4 A . 
J 6 PO4 1   1009 1606 PO4 PO4 A . 
K 5 PEG 1   1010 1607 PEG PEG A . 
L 7 NW4 1   1011 1701 NW4 LIG A . 
M 8 CL  1   1012 1    CL  CL  A . 
N 9 HOH 1   1101 90   HOH HOH A . 
N 9 HOH 2   1102 174  HOH HOH A . 
N 9 HOH 3   1103 259  HOH HOH A . 
N 9 HOH 4   1104 230  HOH HOH A . 
N 9 HOH 5   1105 341  HOH HOH A . 
N 9 HOH 6   1106 125  HOH HOH A . 
N 9 HOH 7   1107 267  HOH HOH A . 
N 9 HOH 8   1108 149  HOH HOH A . 
N 9 HOH 9   1109 175  HOH HOH A . 
N 9 HOH 10  1110 85   HOH HOH A . 
N 9 HOH 11  1111 96   HOH HOH A . 
N 9 HOH 12  1112 273  HOH HOH A . 
N 9 HOH 13  1113 35   HOH HOH A . 
N 9 HOH 14  1114 348  HOH HOH A . 
N 9 HOH 15  1115 11   HOH HOH A . 
N 9 HOH 16  1116 58   HOH HOH A . 
N 9 HOH 17  1117 280  HOH HOH A . 
N 9 HOH 18  1118 242  HOH HOH A . 
N 9 HOH 19  1119 195  HOH HOH A . 
N 9 HOH 20  1120 296  HOH HOH A . 
N 9 HOH 21  1121 401  HOH HOH A . 
N 9 HOH 22  1122 108  HOH HOH A . 
N 9 HOH 23  1123 216  HOH HOH A . 
N 9 HOH 24  1124 193  HOH HOH A . 
N 9 HOH 25  1125 166  HOH HOH A . 
N 9 HOH 26  1126 152  HOH HOH A . 
N 9 HOH 27  1127 226  HOH HOH A . 
N 9 HOH 28  1128 204  HOH HOH A . 
N 9 HOH 29  1129 191  HOH HOH A . 
N 9 HOH 30  1130 250  HOH HOH A . 
N 9 HOH 31  1131 153  HOH HOH A . 
N 9 HOH 32  1132 52   HOH HOH A . 
N 9 HOH 33  1133 136  HOH HOH A . 
N 9 HOH 34  1134 34   HOH HOH A . 
N 9 HOH 35  1135 461  HOH HOH A . 
N 9 HOH 36  1136 214  HOH HOH A . 
N 9 HOH 37  1137 206  HOH HOH A . 
N 9 HOH 38  1138 178  HOH HOH A . 
N 9 HOH 39  1139 165  HOH HOH A . 
N 9 HOH 40  1140 209  HOH HOH A . 
N 9 HOH 41  1141 345  HOH HOH A . 
N 9 HOH 42  1142 31   HOH HOH A . 
N 9 HOH 43  1143 60   HOH HOH A . 
N 9 HOH 44  1144 460  HOH HOH A . 
N 9 HOH 45  1145 223  HOH HOH A . 
N 9 HOH 46  1146 201  HOH HOH A . 
N 9 HOH 47  1147 463  HOH HOH A . 
N 9 HOH 48  1148 89   HOH HOH A . 
N 9 HOH 49  1149 176  HOH HOH A . 
N 9 HOH 50  1150 227  HOH HOH A . 
N 9 HOH 51  1151 239  HOH HOH A . 
N 9 HOH 52  1152 187  HOH HOH A . 
N 9 HOH 53  1153 185  HOH HOH A . 
N 9 HOH 54  1154 81   HOH HOH A . 
N 9 HOH 55  1155 10   HOH HOH A . 
N 9 HOH 56  1156 249  HOH HOH A . 
N 9 HOH 57  1157 197  HOH HOH A . 
N 9 HOH 58  1158 186  HOH HOH A . 
N 9 HOH 59  1159 243  HOH HOH A . 
N 9 HOH 60  1160 217  HOH HOH A . 
N 9 HOH 61  1161 177  HOH HOH A . 
N 9 HOH 62  1162 180  HOH HOH A . 
N 9 HOH 63  1163 292  HOH HOH A . 
N 9 HOH 64  1164 248  HOH HOH A . 
N 9 HOH 65  1165 190  HOH HOH A . 
N 9 HOH 66  1166 269  HOH HOH A . 
N 9 HOH 67  1167 458  HOH HOH A . 
N 9 HOH 68  1168 213  HOH HOH A . 
N 9 HOH 69  1169 258  HOH HOH A . 
N 9 HOH 70  1170 16   HOH HOH A . 
N 9 HOH 71  1171 5    HOH HOH A . 
N 9 HOH 72  1172 188  HOH HOH A . 
N 9 HOH 73  1173 215  HOH HOH A . 
N 9 HOH 74  1174 396  HOH HOH A . 
N 9 HOH 75  1175 170  HOH HOH A . 
N 9 HOH 76  1176 256  HOH HOH A . 
N 9 HOH 77  1177 319  HOH HOH A . 
N 9 HOH 78  1178 199  HOH HOH A . 
N 9 HOH 79  1179 232  HOH HOH A . 
N 9 HOH 80  1180 268  HOH HOH A . 
N 9 HOH 81  1181 2    HOH HOH A . 
N 9 HOH 82  1182 37   HOH HOH A . 
N 9 HOH 83  1183 252  HOH HOH A . 
N 9 HOH 84  1184 198  HOH HOH A . 
N 9 HOH 85  1185 7    HOH HOH A . 
N 9 HOH 86  1186 102  HOH HOH A . 
N 9 HOH 87  1187 281  HOH HOH A . 
N 9 HOH 88  1188 25   HOH HOH A . 
N 9 HOH 89  1189 3    HOH HOH A . 
N 9 HOH 90  1190 260  HOH HOH A . 
N 9 HOH 91  1191 247  HOH HOH A . 
N 9 HOH 92  1192 179  HOH HOH A . 
N 9 HOH 93  1193 189  HOH HOH A . 
N 9 HOH 94  1194 262  HOH HOH A . 
N 9 HOH 95  1195 69   HOH HOH A . 
N 9 HOH 96  1196 220  HOH HOH A . 
N 9 HOH 97  1197 264  HOH HOH A . 
N 9 HOH 98  1198 205  HOH HOH A . 
N 9 HOH 99  1199 210  HOH HOH A . 
N 9 HOH 100 1200 29   HOH HOH A . 
N 9 HOH 101 1201 303  HOH HOH A . 
N 9 HOH 102 1202 307  HOH HOH A . 
N 9 HOH 103 1203 76   HOH HOH A . 
N 9 HOH 104 1204 120  HOH HOH A . 
N 9 HOH 105 1205 300  HOH HOH A . 
N 9 HOH 106 1206 92   HOH HOH A . 
N 9 HOH 107 1207 196  HOH HOH A . 
N 9 HOH 108 1208 19   HOH HOH A . 
N 9 HOH 109 1209 222  HOH HOH A . 
N 9 HOH 110 1210 234  HOH HOH A . 
N 9 HOH 111 1211 317  HOH HOH A . 
N 9 HOH 112 1212 221  HOH HOH A . 
N 9 HOH 113 1213 266  HOH HOH A . 
N 9 HOH 114 1214 182  HOH HOH A . 
N 9 HOH 115 1215 183  HOH HOH A . 
N 9 HOH 116 1216 290  HOH HOH A . 
N 9 HOH 117 1217 203  HOH HOH A . 
N 9 HOH 118 1218 265  HOH HOH A . 
N 9 HOH 119 1219 328  HOH HOH A . 
N 9 HOH 120 1220 104  HOH HOH A . 
N 9 HOH 121 1221 274  HOH HOH A . 
N 9 HOH 122 1222 93   HOH HOH A . 
N 9 HOH 123 1223 225  HOH HOH A . 
N 9 HOH 124 1224 145  HOH HOH A . 
N 9 HOH 125 1225 207  HOH HOH A . 
N 9 HOH 126 1226 408  HOH HOH A . 
N 9 HOH 127 1227 392  HOH HOH A . 
N 9 HOH 128 1228 184  HOH HOH A . 
N 9 HOH 129 1229 127  HOH HOH A . 
N 9 HOH 130 1230 212  HOH HOH A . 
N 9 HOH 131 1231 164  HOH HOH A . 
N 9 HOH 132 1232 143  HOH HOH A . 
N 9 HOH 133 1233 240  HOH HOH A . 
N 9 HOH 134 1234 211  HOH HOH A . 
N 9 HOH 135 1235 151  HOH HOH A . 
N 9 HOH 136 1236 68   HOH HOH A . 
N 9 HOH 137 1237 39   HOH HOH A . 
N 9 HOH 138 1238 133  HOH HOH A . 
N 9 HOH 139 1239 30   HOH HOH A . 
N 9 HOH 140 1240 77   HOH HOH A . 
N 9 HOH 141 1241 99   HOH HOH A . 
N 9 HOH 142 1242 306  HOH HOH A . 
N 9 HOH 143 1243 47   HOH HOH A . 
N 9 HOH 144 1244 150  HOH HOH A . 
N 9 HOH 145 1245 272  HOH HOH A . 
N 9 HOH 146 1246 288  HOH HOH A . 
N 9 HOH 147 1247 251  HOH HOH A . 
N 9 HOH 148 1248 231  HOH HOH A . 
N 9 HOH 149 1249 119  HOH HOH A . 
N 9 HOH 150 1250 275  HOH HOH A . 
N 9 HOH 151 1251 233  HOH HOH A . 
N 9 HOH 152 1252 278  HOH HOH A . 
N 9 HOH 153 1253 245  HOH HOH A . 
N 9 HOH 154 1254 342  HOH HOH A . 
N 9 HOH 155 1255 244  HOH HOH A . 
N 9 HOH 156 1256 218  HOH HOH A . 
N 9 HOH 157 1257 202  HOH HOH A . 
N 9 HOH 158 1258 192  HOH HOH A . 
N 9 HOH 159 1259 294  HOH HOH A . 
N 9 HOH 160 1260 358  HOH HOH A . 
N 9 HOH 161 1261 26   HOH HOH A . 
N 9 HOH 162 1262 276  HOH HOH A . 
N 9 HOH 163 1263 333  HOH HOH A . 
N 9 HOH 164 1264 257  HOH HOH A . 
N 9 HOH 165 1265 293  HOH HOH A . 
N 9 HOH 166 1266 4    HOH HOH A . 
N 9 HOH 167 1267 238  HOH HOH A . 
N 9 HOH 168 1268 277  HOH HOH A . 
N 9 HOH 169 1269 261  HOH HOH A . 
N 9 HOH 170 1270 323  HOH HOH A . 
N 9 HOH 171 1271 395  HOH HOH A . 
N 9 HOH 172 1272 279  HOH HOH A . 
N 9 HOH 173 1273 194  HOH HOH A . 
N 9 HOH 174 1274 322  HOH HOH A . 
N 9 HOH 175 1275 315  HOH HOH A . 
N 9 HOH 176 1276 308  HOH HOH A . 
N 9 HOH 177 1277 361  HOH HOH A . 
N 9 HOH 178 1278 254  HOH HOH A . 
N 9 HOH 179 1279 45   HOH HOH A . 
N 9 HOH 180 1280 311  HOH HOH A . 
N 9 HOH 181 1281 50   HOH HOH A . 
N 9 HOH 182 1282 148  HOH HOH A . 
N 9 HOH 183 1283 346  HOH HOH A . 
N 9 HOH 184 1284 285  HOH HOH A . 
N 9 HOH 185 1285 371  HOH HOH A . 
N 9 HOH 186 1286 289  HOH HOH A . 
N 9 HOH 187 1287 241  HOH HOH A . 
N 9 HOH 188 1288 236  HOH HOH A . 
N 9 HOH 189 1289 320  HOH HOH A . 
N 9 HOH 190 1290 336  HOH HOH A . 
N 9 HOH 191 1291 270  HOH HOH A . 
N 9 HOH 192 1292 284  HOH HOH A . 
N 9 HOH 193 1293 224  HOH HOH A . 
N 9 HOH 194 1294 235  HOH HOH A . 
N 9 HOH 195 1295 331  HOH HOH A . 
N 9 HOH 196 1296 378  HOH HOH A . 
N 9 HOH 197 1297 318  HOH HOH A . 
N 9 HOH 198 1298 302  HOH HOH A . 
N 9 HOH 199 1299 15   HOH HOH A . 
N 9 HOH 200 1300 366  HOH HOH A . 
N 9 HOH 201 1301 309  HOH HOH A . 
N 9 HOH 202 1302 219  HOH HOH A . 
N 9 HOH 203 1303 356  HOH HOH A . 
N 9 HOH 204 1304 298  HOH HOH A . 
N 9 HOH 205 1305 246  HOH HOH A . 
N 9 HOH 206 1306 22   HOH HOH A . 
N 9 HOH 207 1307 334  HOH HOH A . 
N 9 HOH 208 1308 291  HOH HOH A . 
N 9 HOH 209 1309 255  HOH HOH A . 
N 9 HOH 210 1310 321  HOH HOH A . 
N 9 HOH 211 1311 304  HOH HOH A . 
N 9 HOH 212 1312 335  HOH HOH A . 
N 9 HOH 213 1313 339  HOH HOH A . 
N 9 HOH 214 1314 66   HOH HOH A . 
N 9 HOH 215 1315 381  HOH HOH A . 
N 9 HOH 216 1316 360  HOH HOH A . 
N 9 HOH 217 1317 325  HOH HOH A . 
N 9 HOH 218 1318 144  HOH HOH A . 
N 9 HOH 219 1319 271  HOH HOH A . 
N 9 HOH 220 1320 6    HOH HOH A . 
N 9 HOH 221 1321 110  HOH HOH A . 
N 9 HOH 222 1322 365  HOH HOH A . 
N 9 HOH 223 1323 350  HOH HOH A . 
N 9 HOH 224 1324 56   HOH HOH A . 
N 9 HOH 225 1325 314  HOH HOH A . 
N 9 HOH 226 1326 312  HOH HOH A . 
N 9 HOH 227 1327 286  HOH HOH A . 
N 9 HOH 228 1328 368  HOH HOH A . 
N 9 HOH 229 1329 355  HOH HOH A . 
N 9 HOH 230 1330 140  HOH HOH A . 
N 9 HOH 231 1331 389  HOH HOH A . 
N 9 HOH 232 1332 364  HOH HOH A . 
N 9 HOH 233 1333 109  HOH HOH A . 
N 9 HOH 234 1334 313  HOH HOH A . 
N 9 HOH 235 1335 357  HOH HOH A . 
N 9 HOH 236 1336 70   HOH HOH A . 
N 9 HOH 237 1337 67   HOH HOH A . 
N 9 HOH 238 1338 380  HOH HOH A . 
N 9 HOH 239 1339 386  HOH HOH A . 
N 9 HOH 240 1340 82   HOH HOH A . 
N 9 HOH 241 1341 343  HOH HOH A . 
N 9 HOH 242 1342 112  HOH HOH A . 
N 9 HOH 243 1343 369  HOH HOH A . 
N 9 HOH 244 1344 117  HOH HOH A . 
N 9 HOH 245 1345 372  HOH HOH A . 
N 9 HOH 246 1346 330  HOH HOH A . 
N 9 HOH 247 1347 46   HOH HOH A . 
N 9 HOH 248 1348 282  HOH HOH A . 
N 9 HOH 249 1349 297  HOH HOH A . 
N 9 HOH 250 1350 377  HOH HOH A . 
N 9 HOH 251 1351 316  HOH HOH A . 
N 9 HOH 252 1352 32   HOH HOH A . 
N 9 HOH 253 1353 57   HOH HOH A . 
N 9 HOH 254 1354 33   HOH HOH A . 
N 9 HOH 255 1355 384  HOH HOH A . 
N 9 HOH 256 1356 423  HOH HOH A . 
N 9 HOH 257 1357 263  HOH HOH A . 
N 9 HOH 258 1358 399  HOH HOH A . 
N 9 HOH 259 1359 375  HOH HOH A . 
N 9 HOH 260 1360 27   HOH HOH A . 
N 9 HOH 261 1361 14   HOH HOH A . 
N 9 HOH 262 1362 349  HOH HOH A . 
N 9 HOH 263 1363 351  HOH HOH A . 
N 9 HOH 264 1364 24   HOH HOH A . 
N 9 HOH 265 1365 118  HOH HOH A . 
N 9 HOH 266 1366 38   HOH HOH A . 
N 9 HOH 267 1367 42   HOH HOH A . 
N 9 HOH 268 1368 352  HOH HOH A . 
N 9 HOH 269 1369 83   HOH HOH A . 
N 9 HOH 270 1370 464  HOH HOH A . 
N 9 HOH 271 1371 114  HOH HOH A . 
N 9 HOH 272 1372 347  HOH HOH A . 
N 9 HOH 273 1373 326  HOH HOH A . 
N 9 HOH 274 1374 310  HOH HOH A . 
N 9 HOH 275 1375 418  HOH HOH A . 
N 9 HOH 276 1376 18   HOH HOH A . 
N 9 HOH 277 1377 451  HOH HOH A . 
N 9 HOH 278 1378 1    HOH HOH A . 
N 9 HOH 279 1379 394  HOH HOH A . 
N 9 HOH 280 1380 305  HOH HOH A . 
N 9 HOH 281 1381 106  HOH HOH A . 
N 9 HOH 282 1382 100  HOH HOH A . 
N 9 HOH 283 1383 376  HOH HOH A . 
N 9 HOH 284 1384 344  HOH HOH A . 
N 9 HOH 285 1385 340  HOH HOH A . 
N 9 HOH 286 1386 388  HOH HOH A . 
N 9 HOH 287 1387 354  HOH HOH A . 
N 9 HOH 288 1388 98   HOH HOH A . 
N 9 HOH 289 1389 404  HOH HOH A . 
N 9 HOH 290 1390 283  HOH HOH A . 
N 9 HOH 291 1391 287  HOH HOH A . 
N 9 HOH 292 1392 338  HOH HOH A . 
N 9 HOH 293 1393 374  HOH HOH A . 
N 9 HOH 294 1394 237  HOH HOH A . 
N 9 HOH 295 1395 228  HOH HOH A . 
N 9 HOH 296 1396 299  HOH HOH A . 
N 9 HOH 297 1397 367  HOH HOH A . 
N 9 HOH 298 1398 402  HOH HOH A . 
N 9 HOH 299 1399 387  HOH HOH A . 
N 9 HOH 300 1400 383  HOH HOH A . 
N 9 HOH 301 1401 398  HOH HOH A . 
N 9 HOH 302 1402 391  HOH HOH A . 
N 9 HOH 303 1403 379  HOH HOH A . 
N 9 HOH 304 1404 405  HOH HOH A . 
N 9 HOH 305 1405 406  HOH HOH A . 
N 9 HOH 306 1406 393  HOH HOH A . 
N 9 HOH 307 1407 295  HOH HOH A . 
N 9 HOH 308 1408 421  HOH HOH A . 
N 9 HOH 309 1409 411  HOH HOH A . 
N 9 HOH 310 1410 373  HOH HOH A . 
N 9 HOH 311 1411 363  HOH HOH A . 
N 9 HOH 312 1412 359  HOH HOH A . 
N 9 HOH 313 1413 128  HOH HOH A . 
N 9 HOH 314 1414 208  HOH HOH A . 
N 9 HOH 315 1415 410  HOH HOH A . 
N 9 HOH 316 1416 427  HOH HOH A . 
N 9 HOH 317 1417 422  HOH HOH A . 
N 9 HOH 318 1418 65   HOH HOH A . 
N 9 HOH 319 1419 466  HOH HOH A . 
N 9 HOH 320 1420 403  HOH HOH A . 
N 9 HOH 321 1421 132  HOH HOH A . 
N 9 HOH 322 1422 40   HOH HOH A . 
N 9 HOH 323 1423 390  HOH HOH A . 
N 9 HOH 324 1424 416  HOH HOH A . 
N 9 HOH 325 1425 253  HOH HOH A . 
N 9 HOH 326 1426 80   HOH HOH A . 
N 9 HOH 327 1427 459  HOH HOH A . 
N 9 HOH 328 1428 412  HOH HOH A . 
N 9 HOH 329 1429 332  HOH HOH A . 
N 9 HOH 330 1430 444  HOH HOH A . 
N 9 HOH 331 1431 413  HOH HOH A . 
N 9 HOH 332 1432 13   HOH HOH A . 
N 9 HOH 333 1433 23   HOH HOH A . 
N 9 HOH 334 1434 12   HOH HOH A . 
N 9 HOH 335 1435 417  HOH HOH A . 
N 9 HOH 336 1436 91   HOH HOH A . 
N 9 HOH 337 1437 181  HOH HOH A . 
N 9 HOH 338 1438 415  HOH HOH A . 
N 9 HOH 339 1439 409  HOH HOH A . 
N 9 HOH 340 1440 111  HOH HOH A . 
N 9 HOH 341 1441 48   HOH HOH A . 
N 9 HOH 342 1442 429  HOH HOH A . 
N 9 HOH 343 1443 436  HOH HOH A . 
N 9 HOH 344 1444 454  HOH HOH A . 
N 9 HOH 345 1445 43   HOH HOH A . 
N 9 HOH 346 1446 28   HOH HOH A . 
N 9 HOH 347 1447 75   HOH HOH A . 
N 9 HOH 348 1448 431  HOH HOH A . 
N 9 HOH 349 1449 324  HOH HOH A . 
N 9 HOH 350 1450 97   HOH HOH A . 
N 9 HOH 351 1451 41   HOH HOH A . 
N 9 HOH 352 1452 425  HOH HOH A . 
N 9 HOH 353 1453 59   HOH HOH A . 
N 9 HOH 354 1454 428  HOH HOH A . 
N 9 HOH 355 1455 124  HOH HOH A . 
N 9 HOH 356 1456 159  HOH HOH A . 
N 9 HOH 357 1457 329  HOH HOH A . 
N 9 HOH 358 1458 385  HOH HOH A . 
N 9 HOH 359 1459 430  HOH HOH A . 
N 9 HOH 360 1460 63   HOH HOH A . 
N 9 HOH 361 1461 439  HOH HOH A . 
N 9 HOH 362 1462 101  HOH HOH A . 
N 9 HOH 363 1463 426  HOH HOH A . 
N 9 HOH 364 1464 44   HOH HOH A . 
N 9 HOH 365 1465 61   HOH HOH A . 
N 9 HOH 366 1466 437  HOH HOH A . 
N 9 HOH 367 1467 134  HOH HOH A . 
N 9 HOH 368 1468 20   HOH HOH A . 
N 9 HOH 369 1469 397  HOH HOH A . 
N 9 HOH 370 1470 414  HOH HOH A . 
N 9 HOH 371 1471 169  HOH HOH A . 
N 9 HOH 372 1472 424  HOH HOH A . 
N 9 HOH 373 1473 434  HOH HOH A . 
N 9 HOH 374 1474 94   HOH HOH A . 
N 9 HOH 375 1475 452  HOH HOH A . 
N 9 HOH 376 1476 467  HOH HOH A . 
N 9 HOH 377 1477 71   HOH HOH A . 
N 9 HOH 378 1478 407  HOH HOH A . 
N 9 HOH 379 1479 123  HOH HOH A . 
N 9 HOH 380 1480 103  HOH HOH A . 
N 9 HOH 381 1481 432  HOH HOH A . 
N 9 HOH 382 1482 435  HOH HOH A . 
N 9 HOH 383 1483 433  HOH HOH A . 
N 9 HOH 384 1484 337  HOH HOH A . 
N 9 HOH 385 1485 438  HOH HOH A . 
N 9 HOH 386 1486 157  HOH HOH A . 
N 9 HOH 387 1487 456  HOH HOH A . 
N 9 HOH 388 1488 51   HOH HOH A . 
N 9 HOH 389 1489 78   HOH HOH A . 
N 9 HOH 390 1490 8    HOH HOH A . 
N 9 HOH 391 1491 88   HOH HOH A . 
N 9 HOH 392 1492 168  HOH HOH A . 
N 9 HOH 393 1493 301  HOH HOH A . 
N 9 HOH 394 1494 74   HOH HOH A . 
N 9 HOH 395 1495 172  HOH HOH A . 
N 9 HOH 396 1496 462  HOH HOH A . 
N 9 HOH 397 1497 445  HOH HOH A . 
N 9 HOH 398 1498 55   HOH HOH A . 
N 9 HOH 399 1499 442  HOH HOH A . 
N 9 HOH 400 1500 121  HOH HOH A . 
N 9 HOH 401 1501 122  HOH HOH A . 
N 9 HOH 402 1502 441  HOH HOH A . 
N 9 HOH 403 1503 449  HOH HOH A . 
N 9 HOH 404 1504 115  HOH HOH A . 
N 9 HOH 405 1505 420  HOH HOH A . 
N 9 HOH 406 1506 64   HOH HOH A . 
N 9 HOH 407 1507 443  HOH HOH A . 
N 9 HOH 408 1508 448  HOH HOH A . 
N 9 HOH 409 1509 135  HOH HOH A . 
N 9 HOH 410 1510 447  HOH HOH A . 
N 9 HOH 411 1511 440  HOH HOH A . 
N 9 HOH 412 1512 49   HOH HOH A . 
N 9 HOH 413 1513 455  HOH HOH A . 
N 9 HOH 414 1514 9    HOH HOH A . 
N 9 HOH 415 1515 171  HOH HOH A . 
N 9 HOH 416 1516 95   HOH HOH A . 
N 9 HOH 417 1517 17   HOH HOH A . 
N 9 HOH 418 1518 73   HOH HOH A . 
N 9 HOH 419 1519 450  HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A THR 344 ? CB  ? A THR 81 CB  
2 1 Y 1 A THR 344 ? OG1 ? A THR 81 OG1 
3 1 Y 1 A THR 344 ? CG2 ? A THR 81 CG2 
# 
loop_
_software.classification 
_software.name 
_software.version 
_software.citation_id 
_software.pdbx_ordinal 
_software.date 
_software.type 
_software.location 
_software.language 
refinement       REFMAC  5.8.0267 ? 1 ? ? ? ? 
'data scaling'   Aimless .        ? 2 ? ? ? ? 
phasing          PHASER  .        ? 3 ? ? ? ? 
'data reduction' XDS     .        ? 4 ? ? ? ? 
# 
_cell.entry_id           7I2S 
_cell.length_a           82.439 
_cell.length_b           116.667 
_cell.length_c           148.814 
_cell.angle_alpha        90.00 
_cell.angle_beta         90.00 
_cell.angle_gamma        90.00 
_cell.Z_PDB              8 
_cell.pdbx_unique_axis   ? 
# 
_symmetry.entry_id                         7I2S 
_symmetry.space_group_name_H-M             'I 2 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                23 
# 
_exptl.entry_id          7I2S 
_exptl.method            'X-RAY DIFFRACTION' 
_exptl.crystals_number   1 
# 
_exptl_crystal.id                    1 
_exptl_crystal.density_meas          ? 
_exptl_crystal.density_Matthews      2.42 
_exptl_crystal.density_percent_sol   49.20 
_exptl_crystal.description           ? 
_exptl_crystal.preparation           ? 
# 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.temp            293.15 
_exptl_crystal_grow.pdbx_details    '350 mM Magnesium chloride, 10% PEG 4000, 100 mM MES, pH 6.5' 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.pdbx_pH_range   ? 
# 
_diffrn.id                               1 
_diffrn.ambient_temp                     100 
_diffrn.crystal_id                       1 
_diffrn.ambient_temp_details             ? 
_diffrn.pdbx_serial_crystal_experiment   ? 
# 
_diffrn_detector.detector               PIXEL 
_diffrn_detector.type                   'DECTRIS EIGER2 XE 9M' 
_diffrn_detector.pdbx_collection_date   2023-12-05 
_diffrn_detector.diffrn_id              1 
_diffrn_detector.details                ? 
# 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.92124 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.diffrn_id                   1 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.type                        'DIAMOND BEAMLINE I04-1' 
_diffrn_source.pdbx_wavelength_list        0.92124 
_diffrn_source.pdbx_synchrotron_site       Diamond 
_diffrn_source.pdbx_synchrotron_beamline   I04-1 
_diffrn_source.pdbx_wavelength             ? 
# 
_reflns.entry_id                     7I2S 
_reflns.pdbx_diffrn_id               1 
_reflns.pdbx_ordinal                 1 
_reflns.d_resolution_low             49.92 
_reflns.d_resolution_high            1.56 
_reflns.number_obs                   101660 
_reflns.percent_possible_obs         99.8 
_reflns.pdbx_Rmerge_I_obs            0.104 
_reflns.pdbx_netI_over_sigmaI        13.0 
_reflns.pdbx_redundancy              12.7 
_reflns.pdbx_Rrim_I_all              0.108 
_reflns.pdbx_Rpim_I_all              0.030 
_reflns.pdbx_CC_half                 0.999 
_reflns.pdbx_number_measured_all     1294767 
_reflns.pdbx_chi_squared             0.51 
_reflns.observed_criterion_sigma_I   ? 
_reflns.observed_criterion_sigma_F   ? 
_reflns.number_all                   ? 
_reflns.pdbx_Rsym_value              ? 
_reflns.B_iso_Wilson_estimate        ? 
# 
_reflns_shell.pdbx_diffrn_id              1 
_reflns_shell.pdbx_ordinal                1 
_reflns_shell.d_res_high                  1.56 
_reflns_shell.d_res_low                   1.59 
_reflns_shell.number_measured_all         45998 
_reflns_shell.number_unique_obs           4937 
_reflns_shell.Rmerge_I_obs                3.740 
_reflns_shell.pdbx_chi_squared            0.21 
_reflns_shell.pdbx_redundancy             9.3 
_reflns_shell.percent_possible_obs        97.8 
_reflns_shell.pdbx_netI_over_sigmaI_obs   0.4 
_reflns_shell.pdbx_Rrim_I_all             3.958 
_reflns_shell.pdbx_Rpim_I_all             1.275 
_reflns_shell.pdbx_CC_half                0.386 
_reflns_shell.percent_possible_all        ? 
_reflns_shell.pdbx_Rsym_value             ? 
_reflns_shell.meanI_over_sigI_obs         ? 
# 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.entry_id                                 7I2S 
_refine.pdbx_diffrn_id                           1 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     96204 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             49.97 
_refine.ls_d_res_high                            1.56 
_refine.ls_percent_reflns_obs                    99.45 
_refine.ls_R_factor_obs                          0.18913 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       0.18791 
_refine.ls_R_factor_R_free                       0.21142 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 5.1 
_refine.ls_number_reflns_R_free                  5160 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               0.967 
_refine.correlation_coeff_Fo_to_Fc_free          0.961 
_refine.B_iso_mean                               49.553 
_refine.aniso_B[1][1]                            -1.84 
_refine.aniso_B[2][2]                            0.43 
_refine.aniso_B[3][3]                            1.41 
_refine.aniso_B[1][2]                            -0.00 
_refine.aniso_B[1][3]                            0.00 
_refine.aniso_B[2][3]                            -0.00 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_overall_ESU_R                       0.104 
_refine.pdbx_overall_ESU_R_Free                  0.096 
_refine.overall_SU_ML                            0.104 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             3.353 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.pdbx_number_atoms_protein        4703 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         67 
_refine_hist.number_atoms_solvent             419 
_refine_hist.number_atoms_total               5189 
_refine_hist.d_res_high                       1.56 
_refine_hist.d_res_low                        49.97 
# 
loop_
_refine_ls_restr.type 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.weight 
_refine_ls_restr.number 
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.pdbx_restraint_function 
r_bond_refined_d             0.008  0.014  ? 9503  'X-RAY DIFFRACTION' ? 
r_bond_other_d               0.001  0.014  ? 7163  'X-RAY DIFFRACTION' ? 
r_angle_refined_deg          1.434  1.643  ? 10322 'X-RAY DIFFRACTION' ? 
r_angle_other_deg            1.271  1.602  ? 16583 'X-RAY DIFFRACTION' ? 
r_dihedral_angle_1_deg       6.226  5.000  ? 977   'X-RAY DIFFRACTION' ? 
r_dihedral_angle_2_deg       28.860 20.528 ? 436   'X-RAY DIFFRACTION' ? 
r_dihedral_angle_3_deg       15.909 15.000 ? 1418  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_4_deg       17.806 15.000 ? 80    'X-RAY DIFFRACTION' ? 
r_chiral_restr               0.068  0.200  ? 938   'X-RAY DIFFRACTION' ? 
r_gen_planes_refined         0.007  0.020  ? 8915  'X-RAY DIFFRACTION' ? 
r_gen_planes_other           0.002  0.020  ? 1921  'X-RAY DIFFRACTION' ? 
r_nbd_refined                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbd_other                  ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_refined              ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_other                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_refined        ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_other          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_refined          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_other            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_refined       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_other         ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_refined     ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_other       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_refined ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_other   ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_mcbond_it                  2.659  4.968  ? 4591  'X-RAY DIFFRACTION' ? 
r_mcbond_other               2.681  4.968  ? 4493  'X-RAY DIFFRACTION' ? 
r_mcangle_it                 4.664  7.060  ? 4691  'X-RAY DIFFRACTION' ? 
r_mcangle_other              4.663  7.060  ? 4692  'X-RAY DIFFRACTION' ? 
r_scbond_it                  3.034  5.672  ? 4910  'X-RAY DIFFRACTION' ? 
r_scbond_other               3.034  5.672  ? 4910  'X-RAY DIFFRACTION' ? 
r_scangle_it                 ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_scangle_other              5.042  7.974  ? 5628  'X-RAY DIFFRACTION' ? 
r_long_range_B_refined       11.187 44.531 ? 7902  'X-RAY DIFFRACTION' ? 
r_long_range_B_other         11.158 44.208 ? 7788  'X-RAY DIFFRACTION' ? 
r_rigid_bond_restr           ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_free            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_bonded          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.d_res_high                       1.560 
_refine_ls_shell.d_res_low                        1.600 
_refine_ls_shell.number_reflns_R_work             6676 
_refine_ls_shell.R_factor_R_work                  0.433 
_refine_ls_shell.percent_reflns_obs               94.69 
_refine_ls_shell.R_factor_R_free                  0.441 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.number_reflns_R_free             364 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.R_factor_all                     ? 
# 
_struct.entry_id                  7I2S 
_struct.title                     
;Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z31721798 (DNV2_NS5A-x0771)
;
_struct.pdbx_model_details        ? 
_struct.pdbx_CASP_flag            ? 
_struct.pdbx_model_type_details   ? 
# 
_struct_keywords.entry_id        7I2S 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
_struct_keywords.text            
;Diamond Light Source, I04-1, READDI, Dengue Virus, crystallographic fragment screening, PanDDA, XChemExplorer, cluster4x, VIRAL PROTEIN
;
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 4 ? 
H N N 5 ? 
I N N 6 ? 
J N N 6 ? 
K N N 5 ? 
L N N 7 ? 
M N N 8 ? 
N N N 9 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q91H74_9FLAV 
_struct_ref.pdbx_db_accession          Q91H74 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;GIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAMTD
TTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAREA
VEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLS
GVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRPTP
RGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGDDC
VVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQGAG
WSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPWME
DKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_struct_ref.pdbx_align_begin           2757 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              7I2S 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 3 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 637 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q91H74 
_struct_ref_seq.db_align_beg                  2757 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3391 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       266 
_struct_ref_seq.pdbx_auth_seq_align_end       900 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 7I2S GLY A 1 ? UNP Q91H74 ? ? 'expression tag' 264 1 
1 7I2S PRO A 2 ? UNP Q91H74 ? ? 'expression tag' 265 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 10  ? HIS A 25  ? ASN A 273 HIS A 288 1 ? 16 
HELX_P HELX_P2  AA2 ASN A 59  ? LEU A 65  ? ASN A 322 LEU A 328 1 ? 7  
HELX_P HELX_P3  AA3 THR A 66  ? ILE A 71  ? THR A 329 ILE A 334 5 ? 6  
HELX_P HELX_P4  AA4 ILE A 72  ? GLN A 77  ? ILE A 335 GLN A 340 1 ? 6  
HELX_P HELX_P5  AA5 MET A 78  ? MET A 80  ? MET A 341 MET A 343 5 ? 3  
HELX_P HELX_P6  AA6 LYS A 104 ? LYS A 124 ? LYS A 367 LYS A 387 1 ? 21 
HELX_P HELX_P7  AA7 THR A 132 ? ARG A 141 ? THR A 395 ARG A 404 1 ? 10 
HELX_P HELX_P8  AA8 SER A 158 ? ASP A 165 ? SER A 421 ASP A 428 1 ? 8  
HELX_P HELX_P9  AA9 ASP A 165 ? GLU A 181 ? ASP A 428 GLU A 444 1 ? 17 
HELX_P HELX_P10 AB1 TRP A 215 ? GLY A 227 ? TRP A 478 GLY A 490 1 ? 13 
HELX_P HELX_P11 AB2 GLY A 227 ? ASP A 232 ? GLY A 490 ASP A 495 1 ? 6  
HELX_P HELX_P12 AB3 SER A 236 ? LEU A 241 ? SER A 499 LEU A 504 1 ? 6  
HELX_P HELX_P13 AB4 GLY A 248 ? LYS A 261 ? GLY A 511 LYS A 524 1 ? 14 
HELX_P HELX_P14 AB5 GLY A 274 ? ILE A 279 ? GLY A 537 ILE A 542 5 ? 6  
HELX_P HELX_P15 AB6 THR A 280 ? MET A 289 ? THR A 543 MET A 552 1 ? 10 
HELX_P HELX_P16 AB7 VAL A 290 ? MET A 294 ? VAL A 553 MET A 557 5 ? 5  
HELX_P HELX_P17 AB8 GLU A 295 ? TYR A 310 ? GLU A 558 TYR A 573 1 ? 16 
HELX_P HELX_P18 AB9 GLY A 339 ? GLU A 363 ? GLY A 602 GLU A 626 1 ? 25 
HELX_P HELX_P19 AC1 THR A 373 ? ARG A 394 ? THR A 636 ARG A 657 1 ? 22 
HELX_P HELX_P20 AC2 ASP A 408 ? ALA A 414 ? ASP A 671 ALA A 677 5 ? 7  
HELX_P HELX_P21 AC3 LEU A 415 ? MET A 421 ? LEU A 678 MET A 684 1 ? 7  
HELX_P HELX_P22 AC4 ASP A 439 ? VAL A 443 ? ASP A 702 VAL A 706 5 ? 5  
HELX_P HELX_P23 AC5 ASN A 467 ? ARG A 476 ? ASN A 730 ARG A 739 1 ? 10 
HELX_P HELX_P24 AC6 SER A 484 ? TYR A 503 ? SER A 747 TYR A 766 1 ? 20 
HELX_P HELX_P25 AC7 ARG A 506 ? VAL A 520 ? ARG A 769 VAL A 783 1 ? 15 
HELX_P HELX_P26 AC8 ASP A 545 ? ILE A 555 ? ASP A 808 ILE A 818 1 ? 11 
HELX_P HELX_P27 AC9 SER A 569 ? ILE A 573 ? SER A 832 ILE A 836 5 ? 5  
HELX_P HELX_P28 AD1 GLY A 577 ? CYS A 584 ? GLY A 840 CYS A 847 1 ? 8  
HELX_P HELX_P29 AD2 LEU A 590 ? ASN A 599 ? LEU A 853 ASN A 862 1 ? 10 
HELX_P HELX_P30 AD3 ASN A 599 ? GLY A 612 ? ASN A 862 GLY A 875 1 ? 14 
HELX_P HELX_P31 AD4 TYR A 619 ? ARG A 627 ? TYR A 882 ARG A 890 5 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A GLU 175 OE1 ? ? ? 1_555 C ZN . ZN ? ? A GLU 438 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.150 ? ? 
metalc2 metalc ? ? A HIS 179 NE2 ? ? ? 1_555 C ZN . ZN ? ? A HIS 442 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.125 ? ? 
metalc3 metalc ? ? A CYS 184 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 447 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.189 ? ? 
metalc4 metalc ? ? A CYS 187 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 450 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.192 ? ? 
metalc5 metalc ? ? A HIS 449 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 712 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.114 ? ? 
metalc6 metalc ? ? A HIS 451 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 714 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.058 ? ? 
metalc7 metalc ? ? A CYS 465 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 728 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.316 ? ? 
metalc8 metalc ? ? A CYS 584 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 847 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.295 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 NE2 ? A HIS 179 ? A HIS 442 ? 1_555 96.1  ? 
2  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 122.0 ? 
3  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 118.2 ? 
4  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 93.3  ? 
5  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 112.6 ? 
6  SG  ? A CYS 184 ? A CYS 447 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 111.4 ? 
7  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 102.8 ? 
8  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 104.2 ? 
9  NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 109.2 ? 
10 NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 105.7 ? 
11 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 114.2 ? 
12 SG  ? A CYS 465 ? A CYS 728 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 118.9 ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 41  ? GLU A 47  ? ALA A 304 GLU A 310 
AA1 2 VAL A 326 ? ARG A 332 ? VAL A 589 ARG A 595 
AA1 3 LYS A 313 ? ARG A 319 ? LYS A 576 ARG A 582 
AA1 4 TYR A 189 ? ASN A 190 ? TYR A 452 ASN A 453 
AA2 1 MET A 57  ? VAL A 58  ? MET A 320 VAL A 321 
AA2 2 ILE A 477 ? SER A 478 ? ILE A 740 SER A 741 
AA3 1 MET A 395 ? SER A 398 ? MET A 658 SER A 661 
AA3 2 ASP A 401 ? VAL A 404 ? ASP A 664 VAL A 667 
AA4 1 HIS A 449 ? ILE A 454 ? HIS A 712 ILE A 717 
AA4 2 VAL A 460 ? CYS A 465 ? VAL A 723 CYS A 728 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N TYR A 46  ? N TYR A 309 O MET A 327 ? O MET A 590 
AA1 2 3 O ILE A 330 ? O ILE A 593 N VAL A 315 ? N VAL A 578 
AA1 3 4 O VAL A 314 ? O VAL A 577 N TYR A 189 ? N TYR A 452 
AA2 1 2 N MET A 57  ? N MET A 320 O SER A 478 ? O SER A 741 
AA3 1 2 N SER A 398 ? N SER A 661 O ASP A 401 ? O ASP A 664 
AA4 1 2 N LEU A 453 ? N LEU A 716 O LEU A 461 ? O LEU A 724 
# 
_pdbx_entry_details.entry_id                   7I2S 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 OD1 A ASP 664 ? ? O4 A PO4 1008 ? ? 1.90 
2 1 OD1 A ASP 534 ? ? O4 A PO4 1008 ? ? 2.17 
# 
loop_
_pdbx_validate_symm_contact.id 
_pdbx_validate_symm_contact.PDB_model_num 
_pdbx_validate_symm_contact.auth_atom_id_1 
_pdbx_validate_symm_contact.auth_asym_id_1 
_pdbx_validate_symm_contact.auth_comp_id_1 
_pdbx_validate_symm_contact.auth_seq_id_1 
_pdbx_validate_symm_contact.PDB_ins_code_1 
_pdbx_validate_symm_contact.label_alt_id_1 
_pdbx_validate_symm_contact.site_symmetry_1 
_pdbx_validate_symm_contact.auth_atom_id_2 
_pdbx_validate_symm_contact.auth_asym_id_2 
_pdbx_validate_symm_contact.auth_comp_id_2 
_pdbx_validate_symm_contact.auth_seq_id_2 
_pdbx_validate_symm_contact.PDB_ins_code_2 
_pdbx_validate_symm_contact.label_alt_id_2 
_pdbx_validate_symm_contact.site_symmetry_2 
_pdbx_validate_symm_contact.dist 
1 1 O A HOH 1162 ? ? 1_555 O A HOH 1162 ? ? 2_445 1.56 
2 1 O A HOH 1292 ? ? 1_555 O A HOH 1415 ? ? 2_545 2.10 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 HIS A 293 ? ? -171.65 128.23  
2  1 ASP A 297 ? ? -96.80  42.81   
3  1 LYS A 312 ? ? -162.85 97.86   
4  1 GLN A 313 ? ? -175.01 -178.53 
5  1 ASN A 406 ? ? 53.22   103.76  
6  1 LYS A 420 ? ? -65.27  -82.63  
7  1 LEU A 504 ? ? 69.64   -39.08  
8  1 ASN A 575 ? ? -154.06 86.37   
9  1 GLN A 598 ? ? 79.49   157.05  
10 1 HIS A 801 ? A -102.69 71.38   
11 1 HIS A 801 ? B -101.12 69.30   
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 1234 ? N HOH . 
2 1 A HOH 1248 ? N HOH . 
3 1 A HOH 1429 ? N HOH . 
4 1 A HOH 1485 ? N HOH . 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 1518 ? 5.81 . 
2 1 O ? A HOH 1519 ? 6.40 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 264 ? A GLY 1   
2  1 Y 1 A PRO 265 ? A PRO 2   
3  1 Y 1 A GLY 266 ? A GLY 3   
4  1 Y 1 A ILE 267 ? A ILE 4   
5  1 Y 1 A GLU 268 ? A GLU 5   
6  1 Y 1 A SER 269 ? A SER 6   
7  1 Y 1 A GLU 270 ? A GLU 7   
8  1 Y 1 A THR 271 ? A THR 8   
9  1 Y 1 A PRO 272 ? A PRO 9   
10 1 Y 1 A GLY 315 ? A GLY 52  
11 1 Y 1 A SER 316 ? A SER 53  
12 1 Y 1 A ASP 345 ? A ASP 82  
13 1 Y 1 A THR 346 ? A THR 83  
14 1 Y 1 A THR 347 ? A THR 84  
15 1 Y 1 A PRO 348 ? A PRO 85  
16 1 Y 1 A PHE 349 ? A PHE 86  
17 1 Y 1 A GLY 350 ? A GLY 87  
18 1 Y 1 A GLN 351 ? A GLN 88  
19 1 Y 1 A GLN 352 ? A GLN 89  
20 1 Y 1 A ARG 353 ? A ARG 90  
21 1 Y 1 A VAL 354 ? A VAL 91  
22 1 Y 1 A PHE 355 ? A PHE 92  
23 1 Y 1 A PHE 413 ? A PHE 150 
24 1 Y 1 A THR 414 ? A THR 151 
25 1 Y 1 A ASP 415 ? A ASP 152 
26 1 Y 1 A GLU 416 ? A GLU 153 
27 1 Y 1 A ASN 417 ? A ASN 154 
28 1 Y 1 A LYS 418 ? A LYS 155 
29 1 Y 1 A GLY 456 ? A GLY 193 
30 1 Y 1 A LYS 457 ? A LYS 194 
31 1 Y 1 A ARG 458 ? A ARG 195 
32 1 Y 1 A GLU 459 ? A GLU 196 
33 1 Y 1 A LYS 460 ? A LYS 197 
34 1 Y 1 A LYS 461 ? A LYS 198 
35 1 Y 1 A LEU 462 ? A LEU 199 
36 1 Y 1 A GLY 463 ? A GLY 200 
37 1 Y 1 A GLU 464 ? A GLU 201 
38 1 Y 1 A PHE 465 ? A PHE 202 
39 1 Y 1 A GLY 466 ? A GLY 203 
40 1 Y 1 A LYS 467 ? A LYS 204 
41 1 Y 1 A ALA 468 ? A ALA 205 
42 1 Y 1 A LYS 469 ? A LYS 206 
43 1 Y 1 A GLY 470 ? A GLY 207 
44 1 Y 1 A SER 471 ? A SER 208 
45 1 Y 1 A ARG 472 ? A ARG 209 
46 1 Y 1 A PRO 585 ? A PRO 322 
47 1 Y 1 A ARG 586 ? A ARG 323 
48 1 Y 1 A GLY 587 ? A GLY 324 
49 1 Y 1 A TRP 795 ? A TRP 532 
50 1 Y 1 A SER 796 ? A SER 533 
51 1 Y 1 A ILE 797 ? A ILE 534 
52 1 Y 1 A HIS 798 ? A HIS 535 
53 1 Y 1 A GLU 892 ? A GLU 629 
54 1 Y 1 A GLU 893 ? A GLU 630 
55 1 Y 1 A GLU 894 ? A GLU 631 
56 1 Y 1 A GLU 895 ? A GLU 632 
57 1 Y 1 A ALA 896 ? A ALA 633 
58 1 Y 1 A GLY 897 ? A GLY 634 
59 1 Y 1 A VAL 898 ? A VAL 635 
60 1 Y 1 A LEU 899 ? A LEU 636 
61 1 Y 1 A TRP 900 ? A TRP 637 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CL  CL   CL N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
DMS S    S  N N 89  
DMS O    O  N N 90  
DMS C1   C  N N 91  
DMS C2   C  N N 92  
DMS H11  H  N N 93  
DMS H12  H  N N 94  
DMS H13  H  N N 95  
DMS H21  H  N N 96  
DMS H22  H  N N 97  
DMS H23  H  N N 98  
GLN N    N  N N 99  
GLN CA   C  N S 100 
GLN C    C  N N 101 
GLN O    O  N N 102 
GLN CB   C  N N 103 
GLN CG   C  N N 104 
GLN CD   C  N N 105 
GLN OE1  O  N N 106 
GLN NE2  N  N N 107 
GLN OXT  O  N N 108 
GLN H    H  N N 109 
GLN H2   H  N N 110 
GLN HA   H  N N 111 
GLN HB2  H  N N 112 
GLN HB3  H  N N 113 
GLN HG2  H  N N 114 
GLN HG3  H  N N 115 
GLN HE21 H  N N 116 
GLN HE22 H  N N 117 
GLN HXT  H  N N 118 
GLU N    N  N N 119 
GLU CA   C  N S 120 
GLU C    C  N N 121 
GLU O    O  N N 122 
GLU CB   C  N N 123 
GLU CG   C  N N 124 
GLU CD   C  N N 125 
GLU OE1  O  N N 126 
GLU OE2  O  N N 127 
GLU OXT  O  N N 128 
GLU H    H  N N 129 
GLU H2   H  N N 130 
GLU HA   H  N N 131 
GLU HB2  H  N N 132 
GLU HB3  H  N N 133 
GLU HG2  H  N N 134 
GLU HG3  H  N N 135 
GLU HE2  H  N N 136 
GLU HXT  H  N N 137 
GLY N    N  N N 138 
GLY CA   C  N N 139 
GLY C    C  N N 140 
GLY O    O  N N 141 
GLY OXT  O  N N 142 
GLY H    H  N N 143 
GLY H2   H  N N 144 
GLY HA2  H  N N 145 
GLY HA3  H  N N 146 
GLY HXT  H  N N 147 
HIS N    N  N N 148 
HIS CA   C  N S 149 
HIS C    C  N N 150 
HIS O    O  N N 151 
HIS CB   C  N N 152 
HIS CG   C  Y N 153 
HIS ND1  N  Y N 154 
HIS CD2  C  Y N 155 
HIS CE1  C  Y N 156 
HIS NE2  N  Y N 157 
HIS OXT  O  N N 158 
HIS H    H  N N 159 
HIS H2   H  N N 160 
HIS HA   H  N N 161 
HIS HB2  H  N N 162 
HIS HB3  H  N N 163 
HIS HD1  H  N N 164 
HIS HD2  H  N N 165 
HIS HE1  H  N N 166 
HIS HE2  H  N N 167 
HIS HXT  H  N N 168 
HOH O    O  N N 169 
HOH H1   H  N N 170 
HOH H2   H  N N 171 
ILE N    N  N N 172 
ILE CA   C  N S 173 
ILE C    C  N N 174 
ILE O    O  N N 175 
ILE CB   C  N S 176 
ILE CG1  C  N N 177 
ILE CG2  C  N N 178 
ILE CD1  C  N N 179 
ILE OXT  O  N N 180 
ILE H    H  N N 181 
ILE H2   H  N N 182 
ILE HA   H  N N 183 
ILE HB   H  N N 184 
ILE HG12 H  N N 185 
ILE HG13 H  N N 186 
ILE HG21 H  N N 187 
ILE HG22 H  N N 188 
ILE HG23 H  N N 189 
ILE HD11 H  N N 190 
ILE HD12 H  N N 191 
ILE HD13 H  N N 192 
ILE HXT  H  N N 193 
LEU N    N  N N 194 
LEU CA   C  N S 195 
LEU C    C  N N 196 
LEU O    O  N N 197 
LEU CB   C  N N 198 
LEU CG   C  N N 199 
LEU CD1  C  N N 200 
LEU CD2  C  N N 201 
LEU OXT  O  N N 202 
LEU H    H  N N 203 
LEU H2   H  N N 204 
LEU HA   H  N N 205 
LEU HB2  H  N N 206 
LEU HB3  H  N N 207 
LEU HG   H  N N 208 
LEU HD11 H  N N 209 
LEU HD12 H  N N 210 
LEU HD13 H  N N 211 
LEU HD21 H  N N 212 
LEU HD22 H  N N 213 
LEU HD23 H  N N 214 
LEU HXT  H  N N 215 
LYS N    N  N N 216 
LYS CA   C  N S 217 
LYS C    C  N N 218 
LYS O    O  N N 219 
LYS CB   C  N N 220 
LYS CG   C  N N 221 
LYS CD   C  N N 222 
LYS CE   C  N N 223 
LYS NZ   N  N N 224 
LYS OXT  O  N N 225 
LYS H    H  N N 226 
LYS H2   H  N N 227 
LYS HA   H  N N 228 
LYS HB2  H  N N 229 
LYS HB3  H  N N 230 
LYS HG2  H  N N 231 
LYS HG3  H  N N 232 
LYS HD2  H  N N 233 
LYS HD3  H  N N 234 
LYS HE2  H  N N 235 
LYS HE3  H  N N 236 
LYS HZ1  H  N N 237 
LYS HZ2  H  N N 238 
LYS HZ3  H  N N 239 
LYS HXT  H  N N 240 
MES O1   O  N N 241 
MES C2   C  N N 242 
MES C3   C  N N 243 
MES N4   N  N N 244 
MES C5   C  N N 245 
MES C6   C  N N 246 
MES C7   C  N N 247 
MES C8   C  N N 248 
MES S    S  N N 249 
MES O1S  O  N N 250 
MES O2S  O  N N 251 
MES O3S  O  N N 252 
MES H21  H  N N 253 
MES H22  H  N N 254 
MES H31  H  N N 255 
MES H32  H  N N 256 
MES HN4  H  N N 257 
MES H51  H  N N 258 
MES H52  H  N N 259 
MES H61  H  N N 260 
MES H62  H  N N 261 
MES H71  H  N N 262 
MES H72  H  N N 263 
MES H81  H  N N 264 
MES H82  H  N N 265 
MET N    N  N N 266 
MET CA   C  N S 267 
MET C    C  N N 268 
MET O    O  N N 269 
MET CB   C  N N 270 
MET CG   C  N N 271 
MET SD   S  N N 272 
MET CE   C  N N 273 
MET OXT  O  N N 274 
MET H    H  N N 275 
MET H2   H  N N 276 
MET HA   H  N N 277 
MET HB2  H  N N 278 
MET HB3  H  N N 279 
MET HG2  H  N N 280 
MET HG3  H  N N 281 
MET HE1  H  N N 282 
MET HE2  H  N N 283 
MET HE3  H  N N 284 
MET HXT  H  N N 285 
NW4 N1   N  N N 286 
NW4 C4   C  N N 287 
NW4 C5   C  N N 288 
NW4 C6   C  N N 289 
NW4 C7   C  N N 290 
NW4 C8   C  N N 291 
NW4 C10  C  N N 292 
NW4 C13  C  N N 293 
NW4 C1   C  N N 294 
NW4 C11  C  N N 295 
NW4 C12  C  N N 296 
NW4 C2   C  N N 297 
NW4 C3   C  N N 298 
NW4 C9   C  N N 299 
NW4 O1   O  N N 300 
NW4 O2   O  N N 301 
NW4 H1   H  N N 302 
NW4 H2   H  N N 303 
NW4 H3   H  N N 304 
NW4 H4   H  N N 305 
NW4 H5   H  N N 306 
NW4 H6   H  N N 307 
NW4 H7   H  N N 308 
NW4 H8   H  N N 309 
NW4 H9   H  N N 310 
NW4 H10  H  N N 311 
NW4 H11  H  N N 312 
NW4 H12  H  N N 313 
NW4 H13  H  N N 314 
NW4 H14  H  N N 315 
NW4 H15  H  N N 316 
NW4 H16  H  N N 317 
NW4 H17  H  N N 318 
NW4 H18  H  N N 319 
NW4 H19  H  N N 320 
NW4 H20  H  N N 321 
NW4 H21  H  N N 322 
NW4 H22  H  N N 323 
NW4 H23  H  N N 324 
PEG C1   C  N N 325 
PEG O1   O  N N 326 
PEG C2   C  N N 327 
PEG O2   O  N N 328 
PEG C3   C  N N 329 
PEG C4   C  N N 330 
PEG O4   O  N N 331 
PEG H11  H  N N 332 
PEG H12  H  N N 333 
PEG HO1  H  N N 334 
PEG H21  H  N N 335 
PEG H22  H  N N 336 
PEG H31  H  N N 337 
PEG H32  H  N N 338 
PEG H41  H  N N 339 
PEG H42  H  N N 340 
PEG HO4  H  N N 341 
PHE N    N  N N 342 
PHE CA   C  N S 343 
PHE C    C  N N 344 
PHE O    O  N N 345 
PHE CB   C  N N 346 
PHE CG   C  Y N 347 
PHE CD1  C  Y N 348 
PHE CD2  C  Y N 349 
PHE CE1  C  Y N 350 
PHE CE2  C  Y N 351 
PHE CZ   C  Y N 352 
PHE OXT  O  N N 353 
PHE H    H  N N 354 
PHE H2   H  N N 355 
PHE HA   H  N N 356 
PHE HB2  H  N N 357 
PHE HB3  H  N N 358 
PHE HD1  H  N N 359 
PHE HD2  H  N N 360 
PHE HE1  H  N N 361 
PHE HE2  H  N N 362 
PHE HZ   H  N N 363 
PHE HXT  H  N N 364 
PO4 P    P  N N 365 
PO4 O1   O  N N 366 
PO4 O2   O  N N 367 
PO4 O3   O  N N 368 
PO4 O4   O  N N 369 
PRO N    N  N N 370 
PRO CA   C  N S 371 
PRO C    C  N N 372 
PRO O    O  N N 373 
PRO CB   C  N N 374 
PRO CG   C  N N 375 
PRO CD   C  N N 376 
PRO OXT  O  N N 377 
PRO H    H  N N 378 
PRO HA   H  N N 379 
PRO HB2  H  N N 380 
PRO HB3  H  N N 381 
PRO HG2  H  N N 382 
PRO HG3  H  N N 383 
PRO HD2  H  N N 384 
PRO HD3  H  N N 385 
PRO HXT  H  N N 386 
SER N    N  N N 387 
SER CA   C  N S 388 
SER C    C  N N 389 
SER O    O  N N 390 
SER CB   C  N N 391 
SER OG   O  N N 392 
SER OXT  O  N N 393 
SER H    H  N N 394 
SER H2   H  N N 395 
SER HA   H  N N 396 
SER HB2  H  N N 397 
SER HB3  H  N N 398 
SER HG   H  N N 399 
SER HXT  H  N N 400 
THR N    N  N N 401 
THR CA   C  N S 402 
THR C    C  N N 403 
THR O    O  N N 404 
THR CB   C  N R 405 
THR OG1  O  N N 406 
THR CG2  C  N N 407 
THR OXT  O  N N 408 
THR H    H  N N 409 
THR H2   H  N N 410 
THR HA   H  N N 411 
THR HB   H  N N 412 
THR HG1  H  N N 413 
THR HG21 H  N N 414 
THR HG22 H  N N 415 
THR HG23 H  N N 416 
THR HXT  H  N N 417 
TRP N    N  N N 418 
TRP CA   C  N S 419 
TRP C    C  N N 420 
TRP O    O  N N 421 
TRP CB   C  N N 422 
TRP CG   C  Y N 423 
TRP CD1  C  Y N 424 
TRP CD2  C  Y N 425 
TRP NE1  N  Y N 426 
TRP CE2  C  Y N 427 
TRP CE3  C  Y N 428 
TRP CZ2  C  Y N 429 
TRP CZ3  C  Y N 430 
TRP CH2  C  Y N 431 
TRP OXT  O  N N 432 
TRP H    H  N N 433 
TRP H2   H  N N 434 
TRP HA   H  N N 435 
TRP HB2  H  N N 436 
TRP HB3  H  N N 437 
TRP HD1  H  N N 438 
TRP HE1  H  N N 439 
TRP HE3  H  N N 440 
TRP HZ2  H  N N 441 
TRP HZ3  H  N N 442 
TRP HH2  H  N N 443 
TRP HXT  H  N N 444 
TYR N    N  N N 445 
TYR CA   C  N S 446 
TYR C    C  N N 447 
TYR O    O  N N 448 
TYR CB   C  N N 449 
TYR CG   C  Y N 450 
TYR CD1  C  Y N 451 
TYR CD2  C  Y N 452 
TYR CE1  C  Y N 453 
TYR CE2  C  Y N 454 
TYR CZ   C  Y N 455 
TYR OH   O  N N 456 
TYR OXT  O  N N 457 
TYR H    H  N N 458 
TYR H2   H  N N 459 
TYR HA   H  N N 460 
TYR HB2  H  N N 461 
TYR HB3  H  N N 462 
TYR HD1  H  N N 463 
TYR HD2  H  N N 464 
TYR HE1  H  N N 465 
TYR HE2  H  N N 466 
TYR HH   H  N N 467 
TYR HXT  H  N N 468 
VAL N    N  N N 469 
VAL CA   C  N S 470 
VAL C    C  N N 471 
VAL O    O  N N 472 
VAL CB   C  N N 473 
VAL CG1  C  N N 474 
VAL CG2  C  N N 475 
VAL OXT  O  N N 476 
VAL H    H  N N 477 
VAL H2   H  N N 478 
VAL HA   H  N N 479 
VAL HB   H  N N 480 
VAL HG11 H  N N 481 
VAL HG12 H  N N 482 
VAL HG13 H  N N 483 
VAL HG21 H  N N 484 
VAL HG22 H  N N 485 
VAL HG23 H  N N 486 
VAL HXT  H  N N 487 
ZN  ZN   ZN N N 488 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
DMS S   O    doub N N 83  
DMS S   C1   sing N N 84  
DMS S   C2   sing N N 85  
DMS C1  H11  sing N N 86  
DMS C1  H12  sing N N 87  
DMS C1  H13  sing N N 88  
DMS C2  H21  sing N N 89  
DMS C2  H22  sing N N 90  
DMS C2  H23  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
HIS N   CA   sing N N 138 
HIS N   H    sing N N 139 
HIS N   H2   sing N N 140 
HIS CA  C    sing N N 141 
HIS CA  CB   sing N N 142 
HIS CA  HA   sing N N 143 
HIS C   O    doub N N 144 
HIS C   OXT  sing N N 145 
HIS CB  CG   sing N N 146 
HIS CB  HB2  sing N N 147 
HIS CB  HB3  sing N N 148 
HIS CG  ND1  sing Y N 149 
HIS CG  CD2  doub Y N 150 
HIS ND1 CE1  doub Y N 151 
HIS ND1 HD1  sing N N 152 
HIS CD2 NE2  sing Y N 153 
HIS CD2 HD2  sing N N 154 
HIS CE1 NE2  sing Y N 155 
HIS CE1 HE1  sing N N 156 
HIS NE2 HE2  sing N N 157 
HIS OXT HXT  sing N N 158 
HOH O   H1   sing N N 159 
HOH O   H2   sing N N 160 
ILE N   CA   sing N N 161 
ILE N   H    sing N N 162 
ILE N   H2   sing N N 163 
ILE CA  C    sing N N 164 
ILE CA  CB   sing N N 165 
ILE CA  HA   sing N N 166 
ILE C   O    doub N N 167 
ILE C   OXT  sing N N 168 
ILE CB  CG1  sing N N 169 
ILE CB  CG2  sing N N 170 
ILE CB  HB   sing N N 171 
ILE CG1 CD1  sing N N 172 
ILE CG1 HG12 sing N N 173 
ILE CG1 HG13 sing N N 174 
ILE CG2 HG21 sing N N 175 
ILE CG2 HG22 sing N N 176 
ILE CG2 HG23 sing N N 177 
ILE CD1 HD11 sing N N 178 
ILE CD1 HD12 sing N N 179 
ILE CD1 HD13 sing N N 180 
ILE OXT HXT  sing N N 181 
LEU N   CA   sing N N 182 
LEU N   H    sing N N 183 
LEU N   H2   sing N N 184 
LEU CA  C    sing N N 185 
LEU CA  CB   sing N N 186 
LEU CA  HA   sing N N 187 
LEU C   O    doub N N 188 
LEU C   OXT  sing N N 189 
LEU CB  CG   sing N N 190 
LEU CB  HB2  sing N N 191 
LEU CB  HB3  sing N N 192 
LEU CG  CD1  sing N N 193 
LEU CG  CD2  sing N N 194 
LEU CG  HG   sing N N 195 
LEU CD1 HD11 sing N N 196 
LEU CD1 HD12 sing N N 197 
LEU CD1 HD13 sing N N 198 
LEU CD2 HD21 sing N N 199 
LEU CD2 HD22 sing N N 200 
LEU CD2 HD23 sing N N 201 
LEU OXT HXT  sing N N 202 
LYS N   CA   sing N N 203 
LYS N   H    sing N N 204 
LYS N   H2   sing N N 205 
LYS CA  C    sing N N 206 
LYS CA  CB   sing N N 207 
LYS CA  HA   sing N N 208 
LYS C   O    doub N N 209 
LYS C   OXT  sing N N 210 
LYS CB  CG   sing N N 211 
LYS CB  HB2  sing N N 212 
LYS CB  HB3  sing N N 213 
LYS CG  CD   sing N N 214 
LYS CG  HG2  sing N N 215 
LYS CG  HG3  sing N N 216 
LYS CD  CE   sing N N 217 
LYS CD  HD2  sing N N 218 
LYS CD  HD3  sing N N 219 
LYS CE  NZ   sing N N 220 
LYS CE  HE2  sing N N 221 
LYS CE  HE3  sing N N 222 
LYS NZ  HZ1  sing N N 223 
LYS NZ  HZ2  sing N N 224 
LYS NZ  HZ3  sing N N 225 
LYS OXT HXT  sing N N 226 
MES O1  C2   sing N N 227 
MES O1  C6   sing N N 228 
MES C2  C3   sing N N 229 
MES C2  H21  sing N N 230 
MES C2  H22  sing N N 231 
MES C3  N4   sing N N 232 
MES C3  H31  sing N N 233 
MES C3  H32  sing N N 234 
MES N4  C5   sing N N 235 
MES N4  C7   sing N N 236 
MES N4  HN4  sing N N 237 
MES C5  C6   sing N N 238 
MES C5  H51  sing N N 239 
MES C5  H52  sing N N 240 
MES C6  H61  sing N N 241 
MES C6  H62  sing N N 242 
MES C7  C8   sing N N 243 
MES C7  H71  sing N N 244 
MES C7  H72  sing N N 245 
MES C8  S    sing N N 246 
MES C8  H81  sing N N 247 
MES C8  H82  sing N N 248 
MES S   O1S  doub N N 249 
MES S   O2S  doub N N 250 
MES S   O3S  sing N N 251 
MET N   CA   sing N N 252 
MET N   H    sing N N 253 
MET N   H2   sing N N 254 
MET CA  C    sing N N 255 
MET CA  CB   sing N N 256 
MET CA  HA   sing N N 257 
MET C   O    doub N N 258 
MET C   OXT  sing N N 259 
MET CB  CG   sing N N 260 
MET CB  HB2  sing N N 261 
MET CB  HB3  sing N N 262 
MET CG  SD   sing N N 263 
MET CG  HG2  sing N N 264 
MET CG  HG3  sing N N 265 
MET SD  CE   sing N N 266 
MET CE  HE1  sing N N 267 
MET CE  HE2  sing N N 268 
MET CE  HE3  sing N N 269 
MET OXT HXT  sing N N 270 
NW4 C2  C1   sing N N 271 
NW4 C2  C3   sing N N 272 
NW4 C4  C9   sing N N 273 
NW4 C4  C3   sing N N 274 
NW4 C4  C5   sing N N 275 
NW4 C9  C8   sing N N 276 
NW4 C13 N1   sing N N 277 
NW4 C13 C12  sing N N 278 
NW4 C1  O1   doub N N 279 
NW4 C1  N1   sing N N 280 
NW4 C5  C6   sing N N 281 
NW4 N1  C10  sing N N 282 
NW4 C6  C7   sing N N 283 
NW4 C12 O2   sing N N 284 
NW4 C8  C7   sing N N 285 
NW4 C10 C11  sing N N 286 
NW4 O2  C11  sing N N 287 
NW4 C4  H1   sing N N 288 
NW4 C5  H2   sing N N 289 
NW4 C5  H3   sing N N 290 
NW4 C6  H4   sing N N 291 
NW4 C6  H5   sing N N 292 
NW4 C7  H6   sing N N 293 
NW4 C7  H7   sing N N 294 
NW4 C8  H8   sing N N 295 
NW4 C8  H9   sing N N 296 
NW4 C10 H10  sing N N 297 
NW4 C10 H11  sing N N 298 
NW4 C13 H12  sing N N 299 
NW4 C13 H13  sing N N 300 
NW4 C11 H14  sing N N 301 
NW4 C11 H15  sing N N 302 
NW4 C12 H16  sing N N 303 
NW4 C12 H17  sing N N 304 
NW4 C2  H18  sing N N 305 
NW4 C2  H19  sing N N 306 
NW4 C3  H20  sing N N 307 
NW4 C3  H21  sing N N 308 
NW4 C9  H22  sing N N 309 
NW4 C9  H23  sing N N 310 
PEG C1  O1   sing N N 311 
PEG C1  C2   sing N N 312 
PEG C1  H11  sing N N 313 
PEG C1  H12  sing N N 314 
PEG O1  HO1  sing N N 315 
PEG C2  O2   sing N N 316 
PEG C2  H21  sing N N 317 
PEG C2  H22  sing N N 318 
PEG O2  C3   sing N N 319 
PEG C3  C4   sing N N 320 
PEG C3  H31  sing N N 321 
PEG C3  H32  sing N N 322 
PEG C4  O4   sing N N 323 
PEG C4  H41  sing N N 324 
PEG C4  H42  sing N N 325 
PEG O4  HO4  sing N N 326 
PHE N   CA   sing N N 327 
PHE N   H    sing N N 328 
PHE N   H2   sing N N 329 
PHE CA  C    sing N N 330 
PHE CA  CB   sing N N 331 
PHE CA  HA   sing N N 332 
PHE C   O    doub N N 333 
PHE C   OXT  sing N N 334 
PHE CB  CG   sing N N 335 
PHE CB  HB2  sing N N 336 
PHE CB  HB3  sing N N 337 
PHE CG  CD1  doub Y N 338 
PHE CG  CD2  sing Y N 339 
PHE CD1 CE1  sing Y N 340 
PHE CD1 HD1  sing N N 341 
PHE CD2 CE2  doub Y N 342 
PHE CD2 HD2  sing N N 343 
PHE CE1 CZ   doub Y N 344 
PHE CE1 HE1  sing N N 345 
PHE CE2 CZ   sing Y N 346 
PHE CE2 HE2  sing N N 347 
PHE CZ  HZ   sing N N 348 
PHE OXT HXT  sing N N 349 
PO4 P   O1   doub N N 350 
PO4 P   O2   sing N N 351 
PO4 P   O3   sing N N 352 
PO4 P   O4   sing N N 353 
PRO N   CA   sing N N 354 
PRO N   CD   sing N N 355 
PRO N   H    sing N N 356 
PRO CA  C    sing N N 357 
PRO CA  CB   sing N N 358 
PRO CA  HA   sing N N 359 
PRO C   O    doub N N 360 
PRO C   OXT  sing N N 361 
PRO CB  CG   sing N N 362 
PRO CB  HB2  sing N N 363 
PRO CB  HB3  sing N N 364 
PRO CG  CD   sing N N 365 
PRO CG  HG2  sing N N 366 
PRO CG  HG3  sing N N 367 
PRO CD  HD2  sing N N 368 
PRO CD  HD3  sing N N 369 
PRO OXT HXT  sing N N 370 
SER N   CA   sing N N 371 
SER N   H    sing N N 372 
SER N   H2   sing N N 373 
SER CA  C    sing N N 374 
SER CA  CB   sing N N 375 
SER CA  HA   sing N N 376 
SER C   O    doub N N 377 
SER C   OXT  sing N N 378 
SER CB  OG   sing N N 379 
SER CB  HB2  sing N N 380 
SER CB  HB3  sing N N 381 
SER OG  HG   sing N N 382 
SER OXT HXT  sing N N 383 
THR N   CA   sing N N 384 
THR N   H    sing N N 385 
THR N   H2   sing N N 386 
THR CA  C    sing N N 387 
THR CA  CB   sing N N 388 
THR CA  HA   sing N N 389 
THR C   O    doub N N 390 
THR C   OXT  sing N N 391 
THR CB  OG1  sing N N 392 
THR CB  CG2  sing N N 393 
THR CB  HB   sing N N 394 
THR OG1 HG1  sing N N 395 
THR CG2 HG21 sing N N 396 
THR CG2 HG22 sing N N 397 
THR CG2 HG23 sing N N 398 
THR OXT HXT  sing N N 399 
TRP N   CA   sing N N 400 
TRP N   H    sing N N 401 
TRP N   H2   sing N N 402 
TRP CA  C    sing N N 403 
TRP CA  CB   sing N N 404 
TRP CA  HA   sing N N 405 
TRP C   O    doub N N 406 
TRP C   OXT  sing N N 407 
TRP CB  CG   sing N N 408 
TRP CB  HB2  sing N N 409 
TRP CB  HB3  sing N N 410 
TRP CG  CD1  doub Y N 411 
TRP CG  CD2  sing Y N 412 
TRP CD1 NE1  sing Y N 413 
TRP CD1 HD1  sing N N 414 
TRP CD2 CE2  doub Y N 415 
TRP CD2 CE3  sing Y N 416 
TRP NE1 CE2  sing Y N 417 
TRP NE1 HE1  sing N N 418 
TRP CE2 CZ2  sing Y N 419 
TRP CE3 CZ3  doub Y N 420 
TRP CE3 HE3  sing N N 421 
TRP CZ2 CH2  doub Y N 422 
TRP CZ2 HZ2  sing N N 423 
TRP CZ3 CH2  sing Y N 424 
TRP CZ3 HZ3  sing N N 425 
TRP CH2 HH2  sing N N 426 
TRP OXT HXT  sing N N 427 
TYR N   CA   sing N N 428 
TYR N   H    sing N N 429 
TYR N   H2   sing N N 430 
TYR CA  C    sing N N 431 
TYR CA  CB   sing N N 432 
TYR CA  HA   sing N N 433 
TYR C   O    doub N N 434 
TYR C   OXT  sing N N 435 
TYR CB  CG   sing N N 436 
TYR CB  HB2  sing N N 437 
TYR CB  HB3  sing N N 438 
TYR CG  CD1  doub Y N 439 
TYR CG  CD2  sing Y N 440 
TYR CD1 CE1  sing Y N 441 
TYR CD1 HD1  sing N N 442 
TYR CD2 CE2  doub Y N 443 
TYR CD2 HD2  sing N N 444 
TYR CE1 CZ   doub Y N 445 
TYR CE1 HE1  sing N N 446 
TYR CE2 CZ   sing Y N 447 
TYR CE2 HE2  sing N N 448 
TYR CZ  OH   sing N N 449 
TYR OH  HH   sing N N 450 
TYR OXT HXT  sing N N 451 
VAL N   CA   sing N N 452 
VAL N   H    sing N N 453 
VAL N   H2   sing N N 454 
VAL CA  C    sing N N 455 
VAL CA  CB   sing N N 456 
VAL CA  HA   sing N N 457 
VAL C   O    doub N N 458 
VAL C   OXT  sing N N 459 
VAL CB  CG1  sing N N 460 
VAL CB  CG2  sing N N 461 
VAL CB  HB   sing N N 462 
VAL CG1 HG11 sing N N 463 
VAL CG1 HG12 sing N N 464 
VAL CG1 HG13 sing N N 465 
VAL CG2 HG21 sing N N 466 
VAL CG2 HG22 sing N N 467 
VAL CG2 HG23 sing N N 468 
VAL OXT HXT  sing N N 469 
# 
_pdbx_audit_support.ordinal                1 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)' 
_pdbx_audit_support.grant_number           U19AI171292 
_pdbx_audit_support.country                'United States' 
# 
_pdbx_deposit_group.group_id            G_1002341 
_pdbx_deposit_group.group_description   
'Crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_title         
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_type          'changed state' 
# 
_atom_sites.entry_id                    7I2S 
_atom_sites.fract_transf_matrix[1][1]   0.012130 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.008571 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006720 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
# 
loop_
_atom_type.symbol 
C  
CL 
N  
O  
P  
S  
ZN 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ASN A 1 10  ? -13.187 -6.555  -12.559 1.00 90.92  ? 273  ASN A N   1 
ATOM   2    C  CA  . ASN A 1 10  ? -13.093 -7.044  -11.154 1.00 87.90  ? 273  ASN A CA  1 
ATOM   3    C  C   . ASN A 1 10  ? -14.447 -6.761  -10.478 1.00 86.37  ? 273  ASN A C   1 
ATOM   4    O  O   . ASN A 1 10  ? -15.475 -7.234  -11.028 1.00 74.27  ? 273  ASN A O   1 
ATOM   5    C  CB  . ASN A 1 10  ? -11.839 -6.474  -10.465 1.00 92.40  ? 273  ASN A CB  1 
ATOM   6    C  CG  . ASN A 1 10  ? -11.400 -7.218  -9.215  1.00 91.54  ? 273  ASN A CG  1 
ATOM   7    O  OD1 . ASN A 1 10  ? -12.213 -7.540  -8.352  1.00 90.58  ? 273  ASN A OD1 1 
ATOM   8    N  ND2 . ASN A 1 10  ? -10.106 -7.475  -9.089  1.00 88.21  ? 273  ASN A ND2 1 
ATOM   9    N  N   . LEU A 1 11  ? -14.459 -5.975  -9.387  1.00 82.11  ? 274  LEU A N   1 
ATOM   10   C  CA  . LEU A 1 11  ? -15.500 -6.023  -8.319  1.00 72.96  ? 274  LEU A CA  1 
ATOM   11   C  C   . LEU A 1 11  ? -16.834 -5.465  -8.822  1.00 68.16  ? 274  LEU A C   1 
ATOM   12   O  O   . LEU A 1 11  ? -17.856 -5.778  -8.197  1.00 67.18  ? 274  LEU A O   1 
ATOM   13   C  CB  . LEU A 1 11  ? -15.003 -5.282  -7.073  1.00 75.59  ? 274  LEU A CB  1 
ATOM   14   C  CG  . LEU A 1 11  ? -14.430 -6.186  -5.980  1.00 79.57  ? 274  LEU A CG  1 
ATOM   15   C  CD1 . LEU A 1 11  ? -13.474 -5.429  -5.069  1.00 81.91  ? 274  LEU A CD1 1 
ATOM   16   C  CD2 . LEU A 1 11  ? -15.545 -6.830  -5.169  1.00 78.05  ? 274  LEU A CD2 1 
ATOM   17   N  N   . ASP A 1 12  ? -16.840 -4.697  -9.910  1.00 65.36  ? 275  ASP A N   1 
ATOM   18   C  CA  . ASP A 1 12  ? -18.101 -4.256  -10.566 1.00 77.80  ? 275  ASP A CA  1 
ATOM   19   C  C   . ASP A 1 12  ? -18.875 -5.494  -11.051 1.00 79.74  ? 275  ASP A C   1 
ATOM   20   O  O   . ASP A 1 12  ? -20.103 -5.534  -10.839 1.00 81.37  ? 275  ASP A O   1 
ATOM   21   C  CB  . ASP A 1 12  ? -17.831 -3.259  -11.697 1.00 85.76  ? 275  ASP A CB  1 
ATOM   22   C  CG  . ASP A 1 12  ? -16.998 -3.828  -12.831 1.00 94.14  ? 275  ASP A CG  1 
ATOM   23   O  OD1 . ASP A 1 12  ? -16.144 -4.707  -12.555 1.00 102.39 ? 275  ASP A OD1 1 
ATOM   24   O  OD2 . ASP A 1 12  ? -17.220 -3.401  -13.979 1.00 99.71  ? 275  ASP A OD2 1 
ATOM   25   N  N   . ILE A 1 13  ? -18.186 -6.483  -11.642 1.00 71.77  ? 276  ILE A N   1 
ATOM   26   C  CA  . ILE A 1 13  ? -18.819 -7.695  -12.250 1.00 58.12  ? 276  ILE A CA  1 
ATOM   27   C  C   . ILE A 1 13  ? -19.126 -8.728  -11.155 1.00 50.11  ? 276  ILE A C   1 
ATOM   28   O  O   . ILE A 1 13  ? -20.210 -9.330  -11.221 1.00 48.91  ? 276  ILE A O   1 
ATOM   29   C  CB  . ILE A 1 13  ? -17.938 -8.241  -13.393 1.00 62.54  ? 276  ILE A CB  1 
ATOM   30   C  CG1 . ILE A 1 13  ? -17.885 -7.244  -14.559 1.00 57.47  ? 276  ILE A CG1 1 
ATOM   31   C  CG2 . ILE A 1 13  ? -18.410 -9.622  -13.843 1.00 59.89  ? 276  ILE A CG2 1 
ATOM   32   C  CD1 . ILE A 1 13  ? -16.859 -7.567  -15.623 1.00 57.35  ? 276  ILE A CD1 1 
ATOM   33   N  N   . ILE A 1 14  ? -18.254 -8.889  -10.150 1.00 49.82  ? 277  ILE A N   1 
ATOM   34   C  CA  . ILE A 1 14  ? -18.419 -9.935  -9.094  1.00 54.52  ? 277  ILE A CA  1 
ATOM   35   C  C   . ILE A 1 14  ? -18.991 -9.346  -7.788  1.00 56.43  ? 277  ILE A C   1 
ATOM   36   O  O   . ILE A 1 14  ? -19.528 -10.152 -6.996  1.00 59.05  ? 277  ILE A O   1 
ATOM   37   C  CB  . ILE A 1 14  ? -17.095 -10.701 -8.860  1.00 58.52  ? 277  ILE A CB  1 
ATOM   38   C  CG1 . ILE A 1 14  ? -15.988 -9.829  -8.264  1.00 57.70  ? 277  ILE A CG1 1 
ATOM   39   C  CG2 . ILE A 1 14  ? -16.624 -11.374 -10.147 1.00 53.84  ? 277  ILE A CG2 1 
ATOM   40   C  CD1 . ILE A 1 14  ? -14.799 -10.633 -7.772  1.00 59.98  ? 277  ILE A CD1 1 
ATOM   41   N  N   . GLY A 1 15  ? -18.902 -8.022  -7.570  1.00 67.01  ? 278  GLY A N   1 
ATOM   42   C  CA  . GLY A 1 15  ? -19.308 -7.330  -6.320  1.00 65.83  ? 278  GLY A CA  1 
ATOM   43   C  C   . GLY A 1 15  ? -20.726 -7.670  -5.879  1.00 65.00  ? 278  GLY A C   1 
ATOM   44   O  O   . GLY A 1 15  ? -20.909 -8.011  -4.692  1.00 73.25  ? 278  GLY A O   1 
ATOM   45   N  N   . LYS A 1 16  ? -21.685 -7.620  -6.812  1.00 65.68  ? 279  LYS A N   1 
ATOM   46   C  CA  . LYS A 1 16  ? -23.143 -7.842  -6.582  1.00 64.47  ? 279  LYS A CA  1 
ATOM   47   C  C   . LYS A 1 16  ? -23.379 -9.243  -5.995  1.00 67.32  ? 279  LYS A C   1 
ATOM   48   O  O   . LYS A 1 16  ? -24.081 -9.355  -4.967  1.00 64.57  ? 279  LYS A O   1 
ATOM   49   C  CB  . LYS A 1 16  ? -23.871 -7.623  -7.913  1.00 69.00  ? 279  LYS A CB  1 
ATOM   50   C  CG  . LYS A 1 16  ? -25.380 -7.438  -7.848  1.00 73.46  ? 279  LYS A CG  1 
ATOM   51   C  CD  . LYS A 1 16  ? -25.924 -6.615  -9.012  1.00 78.47  ? 279  LYS A CD  1 
ATOM   52   C  CE  . LYS A 1 16  ? -27.328 -7.005  -9.426  1.00 81.53  ? 279  LYS A CE  1 
ATOM   53   N  NZ  . LYS A 1 16  ? -28.249 -7.045  -8.266  1.00 83.13  ? 279  LYS A NZ  1 
ATOM   54   N  N   . ARG A 1 17  ? -22.814 -10.282 -6.621  1.00 61.24  ? 280  ARG A N   1 
ATOM   55   C  CA  . ARG A 1 17  ? -22.890 -11.680 -6.114  1.00 60.61  ? 280  ARG A CA  1 
ATOM   56   C  C   . ARG A 1 17  ? -22.310 -11.741 -4.699  1.00 58.08  ? 280  ARG A C   1 
ATOM   57   O  O   . ARG A 1 17  ? -22.875 -12.473 -3.860  1.00 56.67  ? 280  ARG A O   1 
ATOM   58   C  CB  . ARG A 1 17  ? -22.116 -12.648 -7.021  1.00 57.45  ? 280  ARG A CB  1 
ATOM   59   C  CG  . ARG A 1 17  ? -22.964 -13.323 -8.088  1.00 58.02  ? 280  ARG A CG  1 
ATOM   60   C  CD  . ARG A 1 17  ? -22.101 -14.030 -9.112  1.00 53.93  ? 280  ARG A CD  1 
ATOM   61   N  NE  . ARG A 1 17  ? -21.543 -13.060 -10.038 1.00 49.38  ? 280  ARG A NE  1 
ATOM   62   C  CZ  . ARG A 1 17  ? -20.799 -13.354 -11.092 1.00 50.78  ? 280  ARG A CZ  1 
ATOM   63   N  NH1 . ARG A 1 17  ? -20.481 -14.615 -11.369 1.00 47.16  ? 280  ARG A NH1 1 
ATOM   64   N  NH2 . ARG A 1 17  ? -20.389 -12.375 -11.878 1.00 47.37  ? 280  ARG A NH2 1 
ATOM   65   N  N   . ILE A 1 18  ? -21.181 -11.057 -4.482  1.00 63.94  ? 281  ILE A N   1 
ATOM   66   C  CA  . ILE A 1 18  ? -20.442 -11.045 -3.186  1.00 67.59  ? 281  ILE A CA  1 
ATOM   67   C  C   . ILE A 1 18  ? -21.328 -10.307 -2.172  1.00 72.04  ? 281  ILE A C   1 
ATOM   68   O  O   . ILE A 1 18  ? -21.608 -10.901 -1.104  1.00 73.91  ? 281  ILE A O   1 
ATOM   69   C  CB  . ILE A 1 18  ? -19.034 -10.426 -3.349  1.00 72.96  ? 281  ILE A CB  1 
ATOM   70   C  CG1 . ILE A 1 18  ? -18.127 -11.313 -4.206  1.00 74.85  ? 281  ILE A CG1 1 
ATOM   71   C  CG2 . ILE A 1 18  ? -18.386 -10.138 -2.002  1.00 72.21  ? 281  ILE A CG2 1 
ATOM   72   C  CD1 . ILE A 1 18  ? -16.989 -10.569 -4.860  1.00 76.16  ? 281  ILE A CD1 1 
ATOM   73   N  N   . GLU A 1 19  ? -21.816 -9.114  -2.537  1.00 67.44  ? 282  GLU A N   1 
ATOM   74   C  CA  . GLU A 1 19  ? -22.744 -8.295  -1.704  1.00 75.01  ? 282  GLU A CA  1 
ATOM   75   C  C   . GLU A 1 19  ? -23.876 -9.184  -1.188  1.00 71.34  ? 282  GLU A C   1 
ATOM   76   O  O   . GLU A 1 19  ? -24.060 -9.225  0.035   1.00 72.53  ? 282  GLU A O   1 
ATOM   77   C  CB  . GLU A 1 19  ? -23.342 -7.125  -2.488  1.00 82.28  ? 282  GLU A CB  1 
ATOM   78   C  CG  . GLU A 1 19  ? -22.441 -5.904  -2.556  1.00 88.47  ? 282  GLU A CG  1 
ATOM   79   C  CD  . GLU A 1 19  ? -23.015 -4.736  -3.348  1.00 98.87  ? 282  GLU A CD  1 
ATOM   80   O  OE1 . GLU A 1 19  ? -24.158 -4.852  -3.855  1.00 98.77  ? 282  GLU A OE1 1 
ATOM   81   O  OE2 . GLU A 1 19  ? -22.316 -3.708  -3.463  1.00 105.97 ? 282  GLU A OE2 1 
ATOM   82   N  N   . LYS A 1 20  ? -24.568 -9.887  -2.093  1.00 66.67  ? 283  LYS A N   1 
ATOM   83   C  CA  . LYS A 1 20  ? -25.779 -10.700 -1.790  1.00 64.14  ? 283  LYS A CA  1 
ATOM   84   C  C   . LYS A 1 20  ? -25.458 -11.771 -0.746  1.00 68.35  ? 283  LYS A C   1 
ATOM   85   O  O   . LYS A 1 20  ? -26.245 -11.890 0.217   1.00 70.50  ? 283  LYS A O   1 
ATOM   86   C  CB  . LYS A 1 20  ? -26.329 -11.356 -3.059  1.00 65.49  ? 283  LYS A CB  1 
ATOM   87   C  CG  . LYS A 1 20  ? -27.520 -12.282 -2.852  1.00 62.97  ? 283  LYS A CG  1 
ATOM   88   C  CD  . LYS A 1 20  ? -28.424 -12.375 -4.072  1.00 67.93  ? 283  LYS A CD  1 
ATOM   89   C  CE  . LYS A 1 20  ? -29.714 -13.135 -3.835  1.00 66.84  ? 283  LYS A CE  1 
ATOM   90   N  NZ  . LYS A 1 20  ? -29.466 -14.549 -3.472  1.00 67.81  ? 283  LYS A NZ  1 
ATOM   91   N  N   . ILE A 1 21  ? -24.362 -12.520 -0.926  1.00 68.53  ? 284  ILE A N   1 
ATOM   92   C  CA  . ILE A 1 21  ? -23.975 -13.650 -0.022  1.00 74.03  ? 284  ILE A CA  1 
ATOM   93   C  C   . ILE A 1 21  ? -23.671 -13.077 1.373   1.00 75.34  ? 284  ILE A C   1 
ATOM   94   O  O   . ILE A 1 21  ? -24.114 -13.679 2.386   1.00 68.40  ? 284  ILE A O   1 
ATOM   95   C  CB  . ILE A 1 21  ? -22.767 -14.440 -0.575  1.00 74.73  ? 284  ILE A CB  1 
ATOM   96   C  CG1 . ILE A 1 21  ? -23.050 -15.081 -1.936  1.00 77.61  ? 284  ILE A CG1 1 
ATOM   97   C  CG2 . ILE A 1 21  ? -22.291 -15.482 0.433   1.00 74.53  ? 284  ILE A CG2 1 
ATOM   98   C  CD1 . ILE A 1 21  ? -21.797 -15.376 -2.742  1.00 74.47  ? 284  ILE A CD1 1 
ATOM   99   N  N   . LYS A 1 22  ? -22.917 -11.974 1.411   1.00 76.17  ? 285  LYS A N   1 
ATOM   100  C  CA  . LYS A 1 22  ? -22.518 -11.235 2.642   1.00 86.19  ? 285  LYS A CA  1 
ATOM   101  C  C   . LYS A 1 22  ? -23.710 -11.118 3.604   1.00 83.35  ? 285  LYS A C   1 
ATOM   102  O  O   . LYS A 1 22  ? -23.543 -11.438 4.787   1.00 84.33  ? 285  LYS A O   1 
ATOM   103  C  CB  . LYS A 1 22  ? -21.987 -9.846  2.269   1.00 93.22  ? 285  LYS A CB  1 
ATOM   104  C  CG  . LYS A 1 22  ? -20.915 -9.291  3.196   1.00 94.34  ? 285  LYS A CG  1 
ATOM   105  C  CD  . LYS A 1 22  ? -20.447 -7.898  2.828   1.00 96.11  ? 285  LYS A CD  1 
ATOM   106  C  CE  . LYS A 1 22  ? -19.545 -7.286  3.882   1.00 101.47 ? 285  LYS A CE  1 
ATOM   107  N  NZ  . LYS A 1 22  ? -19.657 -5.808  3.909   1.00 102.34 ? 285  LYS A NZ  1 
ATOM   108  N  N   . GLN A 1 23  ? -24.878 -10.718 3.101   1.00 83.49  ? 286  GLN A N   1 
ATOM   109  C  CA  . GLN A 1 23  ? -26.053 -10.318 3.922   1.00 82.41  ? 286  GLN A CA  1 
ATOM   110  C  C   . GLN A 1 23  ? -26.839 -11.535 4.418   1.00 82.26  ? 286  GLN A C   1 
ATOM   111  O  O   . GLN A 1 23  ? -27.422 -11.434 5.506   1.00 96.33  ? 286  GLN A O   1 
ATOM   112  C  CB  . GLN A 1 23  ? -26.947 -9.395  3.107   1.00 78.39  ? 286  GLN A CB  1 
ATOM   113  C  CG  . GLN A 1 23  ? -26.193 -8.176  2.611   1.00 77.49  ? 286  GLN A CG  1 
ATOM   114  C  CD  . GLN A 1 23  ? -27.102 -7.242  1.866   1.00 81.03  ? 286  GLN A CD  1 
ATOM   115  O  OE1 . GLN A 1 23  ? -28.304 -7.477  1.763   1.00 87.66  ? 286  GLN A OE1 1 
ATOM   116  N  NE2 . GLN A 1 23  ? -26.525 -6.174  1.342   1.00 88.29  ? 286  GLN A NE2 1 
ATOM   117  N  N   . GLU A 1 24  ? -26.878 -12.631 3.661   1.00 73.74  ? 287  GLU A N   1 
ATOM   118  C  CA  . GLU A 1 24  ? -27.564 -13.879 4.088   1.00 78.95  ? 287  GLU A CA  1 
ATOM   119  C  C   . GLU A 1 24  ? -26.810 -14.484 5.278   1.00 82.77  ? 287  GLU A C   1 
ATOM   120  O  O   . GLU A 1 24  ? -27.381 -15.360 5.969   1.00 82.33  ? 287  GLU A O   1 
ATOM   121  C  CB  . GLU A 1 24  ? -27.637 -14.886 2.940   1.00 79.75  ? 287  GLU A CB  1 
ATOM   122  C  CG  . GLU A 1 24  ? -28.484 -14.419 1.773   1.00 85.87  ? 287  GLU A CG  1 
ATOM   123  C  CD  . GLU A 1 24  ? -27.894 -14.751 0.412   1.00 91.56  ? 287  GLU A CD  1 
ATOM   124  O  OE1 . GLU A 1 24  ? -27.813 -13.833 -0.422  1.00 91.31  ? 287  GLU A OE1 1 
ATOM   125  O  OE2 . GLU A 1 24  ? -27.502 -15.925 0.198   1.00 87.45  ? 287  GLU A OE2 1 
ATOM   126  N  N   . HIS A 1 25  ? -25.561 -14.059 5.483   1.00 87.36  ? 288  HIS A N   1 
ATOM   127  C  CA  . HIS A 1 25  ? -24.683 -14.505 6.595   1.00 93.46  ? 288  HIS A CA  1 
ATOM   128  C  C   . HIS A 1 25  ? -24.092 -13.264 7.282   1.00 101.82 ? 288  HIS A C   1 
ATOM   129  O  O   . HIS A 1 25  ? -22.875 -13.271 7.586   1.00 105.92 ? 288  HIS A O   1 
ATOM   130  C  CB  . HIS A 1 25  ? -23.650 -15.506 6.050   1.00 86.56  ? 288  HIS A CB  1 
ATOM   131  C  CG  . HIS A 1 25  ? -24.261 -16.621 5.262   1.00 82.65  ? 288  HIS A CG  1 
ATOM   132  N  ND1 . HIS A 1 25  ? -24.803 -17.745 5.863   1.00 85.00  ? 288  HIS A ND1 1 
ATOM   133  C  CD2 . HIS A 1 25  ? -24.434 -16.789 3.932   1.00 78.36  ? 288  HIS A CD2 1 
ATOM   134  C  CE1 . HIS A 1 25  ? -25.279 -18.556 4.937   1.00 83.11  ? 288  HIS A CE1 1 
ATOM   135  N  NE2 . HIS A 1 25  ? -25.065 -17.993 3.744   1.00 78.50  ? 288  HIS A NE2 1 
ATOM   136  N  N   . GLU A 1 26  ? -24.937 -12.249 7.525   1.00 103.34 ? 289  GLU A N   1 
ATOM   137  C  CA  . GLU A 1 26  ? -24.575 -10.944 8.156   1.00 109.66 ? 289  GLU A CA  1 
ATOM   138  C  C   . GLU A 1 26  ? -24.093 -11.181 9.595   1.00 114.15 ? 289  GLU A C   1 
ATOM   139  O  O   . GLU A 1 26  ? -23.317 -10.346 10.099  1.00 111.87 ? 289  GLU A O   1 
ATOM   140  C  CB  . GLU A 1 26  ? -25.771 -9.984  8.142   1.00 103.13 ? 289  GLU A CB  1 
ATOM   141  C  CG  . GLU A 1 26  ? -25.424 -8.544  8.493   1.00 98.09  ? 289  GLU A CG  1 
ATOM   142  C  CD  . GLU A 1 26  ? -24.733 -7.755  7.390   1.00 98.26  ? 289  GLU A CD  1 
ATOM   143  O  OE1 . GLU A 1 26  ? -23.643 -7.218  7.654   1.00 87.06  ? 289  GLU A OE1 1 
ATOM   144  O  OE2 . GLU A 1 26  ? -25.292 -7.665  6.272   1.00 97.92  ? 289  GLU A OE2 1 
ATOM   145  N  N   . THR A 1 27  ? -24.537 -12.275 10.226  1.00 115.94 ? 290  THR A N   1 
ATOM   146  C  CA  . THR A 1 27  ? -24.168 -12.675 11.611  1.00 118.12 ? 290  THR A CA  1 
ATOM   147  C  C   . THR A 1 27  ? -22.753 -13.281 11.658  1.00 119.00 ? 290  THR A C   1 
ATOM   148  O  O   . THR A 1 27  ? -22.189 -13.299 12.769  1.00 127.90 ? 290  THR A O   1 
ATOM   149  C  CB  . THR A 1 27  ? -25.208 -13.636 12.209  1.00 117.96 ? 290  THR A CB  1 
ATOM   150  O  OG1 . THR A 1 27  ? -25.693 -14.504 11.182  1.00 121.30 ? 290  THR A OG1 1 
ATOM   151  C  CG2 . THR A 1 27  ? -26.377 -12.915 12.845  1.00 115.32 ? 290  THR A CG2 1 
ATOM   152  N  N   . SER A 1 28  ? -22.190 -13.739 10.527  1.00 111.76 ? 291  SER A N   1 
ATOM   153  C  CA  . SER A 1 28  ? -20.965 -14.592 10.476  1.00 98.72  ? 291  SER A CA  1 
ATOM   154  C  C   . SER A 1 28  ? -19.813 -13.967 9.666   1.00 88.83  ? 291  SER A C   1 
ATOM   155  O  O   . SER A 1 28  ? -18.703 -14.524 9.728   1.00 74.28  ? 291  SER A O   1 
ATOM   156  C  CB  . SER A 1 28  ? -21.305 -15.960 9.939   1.00 99.59  ? 291  SER A CB  1 
ATOM   157  O  OG  . SER A 1 28  ? -22.106 -16.685 10.862  1.00 100.44 ? 291  SER A OG  1 
ATOM   158  N  N   . TRP A 1 29  ? -20.028 -12.872 8.931   1.00 85.64  ? 292  TRP A N   1 
ATOM   159  C  CA  . TRP A 1 29  ? -19.012 -12.329 7.983   1.00 88.34  ? 292  TRP A CA  1 
ATOM   160  C  C   . TRP A 1 29  ? -17.756 -11.898 8.753   1.00 85.80  ? 292  TRP A C   1 
ATOM   161  O  O   . TRP A 1 29  ? -17.907 -11.390 9.874   1.00 97.01  ? 292  TRP A O   1 
ATOM   162  C  CB  . TRP A 1 29  ? -19.587 -11.182 7.143   1.00 80.28  ? 292  TRP A CB  1 
ATOM   163  C  CG  . TRP A 1 29  ? -18.807 -10.879 5.897   1.00 82.50  ? 292  TRP A CG  1 
ATOM   164  C  CD1 . TRP A 1 29  ? -18.029 -9.781  5.653   1.00 83.65  ? 292  TRP A CD1 1 
ATOM   165  C  CD2 . TRP A 1 29  ? -18.741 -11.685 4.705   1.00 78.89  ? 292  TRP A CD2 1 
ATOM   166  N  NE1 . TRP A 1 29  ? -17.488 -9.845  4.396   1.00 78.68  ? 292  TRP A NE1 1 
ATOM   167  C  CE2 . TRP A 1 29  ? -17.902 -11.005 3.792   1.00 82.29  ? 292  TRP A CE2 1 
ATOM   168  C  CE3 . TRP A 1 29  ? -19.307 -12.907 4.322   1.00 76.16  ? 292  TRP A CE3 1 
ATOM   169  C  CZ2 . TRP A 1 29  ? -17.627 -11.509 2.520   1.00 78.51  ? 292  TRP A CZ2 1 
ATOM   170  C  CZ3 . TRP A 1 29  ? -19.032 -13.404 3.067   1.00 74.95  ? 292  TRP A CZ3 1 
ATOM   171  C  CH2 . TRP A 1 29  ? -18.203 -12.713 2.182   1.00 74.49  ? 292  TRP A CH2 1 
ATOM   172  N  N   . HIS A 1 30  ? -16.570 -12.109 8.167   1.00 88.31  ? 293  HIS A N   1 
ATOM   173  C  CA  . HIS A 1 30  ? -15.242 -11.736 8.732   1.00 85.39  ? 293  HIS A CA  1 
ATOM   174  C  C   . HIS A 1 30  ? -14.140 -11.947 7.690   1.00 90.85  ? 293  HIS A C   1 
ATOM   175  O  O   . HIS A 1 30  ? -14.070 -13.058 7.143   1.00 91.22  ? 293  HIS A O   1 
ATOM   176  C  CB  . HIS A 1 30  ? -14.935 -12.544 10.003  1.00 85.11  ? 293  HIS A CB  1 
ATOM   177  C  CG  . HIS A 1 30  ? -14.803 -14.023 9.827   1.00 74.90  ? 293  HIS A CG  1 
ATOM   178  N  ND1 . HIS A 1 30  ? -15.894 -14.872 9.833   1.00 72.07  ? 293  HIS A ND1 1 
ATOM   179  C  CD2 . HIS A 1 30  ? -13.713 -14.819 9.730   1.00 79.02  ? 293  HIS A CD2 1 
ATOM   180  C  CE1 . HIS A 1 30  ? -15.490 -16.122 9.720   1.00 68.14  ? 293  HIS A CE1 1 
ATOM   181  N  NE2 . HIS A 1 30  ? -14.153 -16.119 9.654   1.00 77.27  ? 293  HIS A NE2 1 
ATOM   182  N  N   . TYR A 1 31  ? -13.303 -10.933 7.440   1.00 92.36  ? 294  TYR A N   1 
ATOM   183  C  CA  . TYR A 1 31  ? -12.091 -11.064 6.590   1.00 96.89  ? 294  TYR A CA  1 
ATOM   184  C  C   . TYR A 1 31  ? -11.022 -11.821 7.386   1.00 100.32 ? 294  TYR A C   1 
ATOM   185  O  O   . TYR A 1 31  ? -10.129 -11.173 7.966   1.00 107.63 ? 294  TYR A O   1 
ATOM   186  C  CB  . TYR A 1 31  ? -11.574 -9.711  6.085   1.00 102.20 ? 294  TYR A CB  1 
ATOM   187  C  CG  . TYR A 1 31  ? -10.618 -9.841  4.921   1.00 112.48 ? 294  TYR A CG  1 
ATOM   188  C  CD1 . TYR A 1 31  ? -9.323  -10.307 5.100   1.00 119.35 ? 294  TYR A CD1 1 
ATOM   189  C  CD2 . TYR A 1 31  ? -11.022 -9.551  3.626   1.00 112.46 ? 294  TYR A CD2 1 
ATOM   190  C  CE1 . TYR A 1 31  ? -8.451  -10.463 4.034   1.00 119.57 ? 294  TYR A CE1 1 
ATOM   191  C  CE2 . TYR A 1 31  ? -10.162 -9.697  2.549   1.00 116.00 ? 294  TYR A CE2 1 
ATOM   192  C  CZ  . TYR A 1 31  ? -8.872  -10.154 2.753   1.00 116.78 ? 294  TYR A CZ  1 
ATOM   193  O  OH  . TYR A 1 31  ? -8.022  -10.309 1.699   1.00 121.00 ? 294  TYR A OH  1 
ATOM   194  N  N   . ASP A 1 32  ? -11.120 -13.155 7.414   1.00 102.41 ? 295  ASP A N   1 
ATOM   195  C  CA  . ASP A 1 32  ? -10.102 -14.067 8.008   1.00 100.39 ? 295  ASP A CA  1 
ATOM   196  C  C   . ASP A 1 32  ? -8.713  -13.648 7.506   1.00 107.46 ? 295  ASP A C   1 
ATOM   197  O  O   . ASP A 1 32  ? -8.558  -13.415 6.280   1.00 112.80 ? 295  ASP A O   1 
ATOM   198  C  CB  . ASP A 1 32  ? -10.395 -15.537 7.684   1.00 91.43  ? 295  ASP A CB  1 
ATOM   199  C  CG  . ASP A 1 32  ? -9.512  -16.542 8.404   1.00 86.63  ? 295  ASP A CG  1 
ATOM   200  O  OD1 . ASP A 1 32  ? -8.413  -16.162 8.848   1.00 81.88  ? 295  ASP A OD1 1 
ATOM   201  O  OD2 . ASP A 1 32  ? -9.936  -17.701 8.515   1.00 83.91  ? 295  ASP A OD2 1 
ATOM   202  N  N   . GLN A 1 33  ? -7.753  -13.539 8.429   1.00 102.06 ? 296  GLN A N   1 
ATOM   203  C  CA  . GLN A 1 33  ? -6.356  -13.117 8.146   1.00 100.58 ? 296  GLN A CA  1 
ATOM   204  C  C   . GLN A 1 33  ? -5.512  -14.360 7.840   1.00 95.97  ? 296  GLN A C   1 
ATOM   205  O  O   . GLN A 1 33  ? -4.489  -14.201 7.143   1.00 94.53  ? 296  GLN A O   1 
ATOM   206  C  CB  . GLN A 1 33  ? -5.810  -12.297 9.318   1.00 100.04 ? 296  GLN A CB  1 
ATOM   207  C  CG  . GLN A 1 33  ? -6.421  -10.906 9.415   1.00 101.70 ? 296  GLN A CG  1 
ATOM   208  C  CD  . GLN A 1 33  ? -5.999  -10.028 8.260   1.00 105.36 ? 296  GLN A CD  1 
ATOM   209  O  OE1 . GLN A 1 33  ? -4.813  -9.831  8.010   1.00 107.93 ? 296  GLN A OE1 1 
ATOM   210  N  NE2 . GLN A 1 33  ? -6.970  -9.489  7.539   1.00 106.98 ? 296  GLN A NE2 1 
ATOM   211  N  N   . ASP A 1 34  ? -5.941  -15.537 8.322   1.00 91.97  ? 297  ASP A N   1 
ATOM   212  C  CA  . ASP A 1 34  ? -5.271  -16.854 8.128   1.00 95.44  ? 297  ASP A CA  1 
ATOM   213  C  C   . ASP A 1 34  ? -5.921  -17.608 6.953   1.00 104.07 ? 297  ASP A C   1 
ATOM   214  O  O   . ASP A 1 34  ? -6.134  -18.833 7.095   1.00 107.78 ? 297  ASP A O   1 
ATOM   215  C  CB  . ASP A 1 34  ? -5.325  -17.703 9.408   1.00 93.80  ? 297  ASP A CB  1 
ATOM   216  C  CG  . ASP A 1 34  ? -4.370  -17.276 10.518  1.00 93.93  ? 297  ASP A CG  1 
ATOM   217  O  OD1 . ASP A 1 34  ? -4.862  -16.944 11.615  1.00 93.35  ? 297  ASP A OD1 1 
ATOM   218  O  OD2 . ASP A 1 34  ? -3.140  -17.308 10.292  1.00 90.65  ? 297  ASP A OD2 1 
ATOM   219  N  N   . HIS A 1 35  ? -6.219  -16.926 5.836   1.00 102.80 ? 298  HIS A N   1 
ATOM   220  C  CA  . HIS A 1 35  ? -6.806  -17.540 4.609   1.00 91.86  ? 298  HIS A CA  1 
ATOM   221  C  C   . HIS A 1 35  ? -5.693  -18.208 3.799   1.00 90.49  ? 298  HIS A C   1 
ATOM   222  O  O   . HIS A 1 35  ? -4.641  -17.603 3.590   1.00 83.41  ? 298  HIS A O   1 
ATOM   223  C  CB  . HIS A 1 35  ? -7.644  -16.518 3.816   1.00 87.26  ? 298  HIS A CB  1 
ATOM   224  C  CG  . HIS A 1 35  ? -6.894  -15.472 3.051   1.00 80.60  ? 298  HIS A CG  1 
ATOM   225  N  ND1 . HIS A 1 35  ? -7.027  -14.120 3.327   1.00 80.99  ? 298  HIS A ND1 1 
ATOM   226  C  CD2 . HIS A 1 35  ? -6.081  -15.551 1.974   1.00 72.62  ? 298  HIS A CD2 1 
ATOM   227  C  CE1 . HIS A 1 35  ? -6.302  -13.419 2.480   1.00 77.62  ? 298  HIS A CE1 1 
ATOM   228  N  NE2 . HIS A 1 35  ? -5.701  -14.275 1.648   1.00 80.41  ? 298  HIS A NE2 1 
ATOM   229  N  N   . PRO A 1 36  ? -5.875  -19.474 3.338   1.00 84.34  ? 299  PRO A N   1 
ATOM   230  C  CA  . PRO A 1 36  ? -4.827  -20.202 2.615   1.00 79.20  ? 299  PRO A CA  1 
ATOM   231  C  C   . PRO A 1 36  ? -4.579  -19.822 1.144   1.00 82.39  ? 299  PRO A C   1 
ATOM   232  O  O   . PRO A 1 36  ? -3.663  -20.368 0.565   1.00 92.81  ? 299  PRO A O   1 
ATOM   233  C  CB  . PRO A 1 36  ? -5.337  -21.651 2.640   1.00 79.73  ? 299  PRO A CB  1 
ATOM   234  C  CG  . PRO A 1 36  ? -6.841  -21.512 2.661   1.00 80.90  ? 299  PRO A CG  1 
ATOM   235  C  CD  . PRO A 1 36  ? -7.092  -20.286 3.512   1.00 85.22  ? 299  PRO A CD  1 
ATOM   236  N  N   . TYR A 1 37  ? -5.382  -18.929 0.562   1.00 80.41  ? 300  TYR A N   1 
ATOM   237  C  CA  . TYR A 1 37  ? -5.413  -18.689 -0.905  1.00 75.48  ? 300  TYR A CA  1 
ATOM   238  C  C   . TYR A 1 37  ? -4.241  -17.791 -1.294  1.00 75.33  ? 300  TYR A C   1 
ATOM   239  O  O   . TYR A 1 37  ? -3.940  -16.827 -0.555  1.00 76.81  ? 300  TYR A O   1 
ATOM   240  C  CB  . TYR A 1 37  ? -6.780  -18.144 -1.330  1.00 72.34  ? 300  TYR A CB  1 
ATOM   241  C  CG  . TYR A 1 37  ? -7.898  -19.029 -0.854  1.00 62.13  ? 300  TYR A CG  1 
ATOM   242  C  CD1 . TYR A 1 37  ? -8.072  -20.296 -1.379  1.00 65.19  ? 300  TYR A CD1 1 
ATOM   243  C  CD2 . TYR A 1 37  ? -8.707  -18.650 0.195   1.00 61.11  ? 300  TYR A CD2 1 
ATOM   244  C  CE1 . TYR A 1 37  ? -9.050  -21.151 -0.903  1.00 62.84  ? 300  TYR A CE1 1 
ATOM   245  C  CE2 . TYR A 1 37  ? -9.688  -19.491 0.685   1.00 62.21  ? 300  TYR A CE2 1 
ATOM   246  C  CZ  . TYR A 1 37  ? -9.868  -20.739 0.128   1.00 55.70  ? 300  TYR A CZ  1 
ATOM   247  O  OH  . TYR A 1 37  ? -10.834 -21.572 0.590   1.00 69.66  ? 300  TYR A OH  1 
ATOM   248  N  N   . LYS A 1 38  ? -3.598  -18.132 -2.415  1.00 74.29  ? 301  LYS A N   1 
ATOM   249  C  CA  . LYS A 1 38  ? -2.520  -17.323 -3.040  1.00 70.62  ? 301  LYS A CA  1 
ATOM   250  C  C   . LYS A 1 38  ? -2.922  -16.791 -4.424  1.00 71.56  ? 301  LYS A C   1 
ATOM   251  O  O   . LYS A 1 38  ? -2.746  -15.585 -4.678  1.00 69.28  ? 301  LYS A O   1 
ATOM   252  C  CB  . LYS A 1 38  ? -1.219  -18.120 -3.167  1.00 71.02  ? 301  LYS A CB  1 
ATOM   253  C  CG  . LYS A 1 38  ? 0.015   -17.258 -3.431  1.00 77.51  ? 301  LYS A CG  1 
ATOM   254  C  CD  . LYS A 1 38  ? 0.167   -16.075 -2.475  1.00 75.90  ? 301  LYS A CD  1 
ATOM   255  C  CE  . LYS A 1 38  ? 1.315   -15.152 -2.831  1.00 83.59  ? 301  LYS A CE  1 
ATOM   256  N  NZ  . LYS A 1 38  ? 2.583   -15.562 -2.179  1.00 87.85  ? 301  LYS A NZ  1 
ATOM   257  N  N   . THR A 1 39  ? -3.456  -17.666 -5.284  0.50 69.54  ? 302  THR A N   1 
ATOM   258  C  CA  . THR A 1 39  ? -3.838  -17.356 -6.690  0.50 67.66  ? 302  THR A CA  1 
ATOM   259  C  C   . THR A 1 39  ? -5.332  -17.019 -6.768  0.50 64.37  ? 302  THR A C   1 
ATOM   260  O  O   . THR A 1 39  ? -5.735  -16.378 -7.755  0.50 63.80  ? 302  THR A O   1 
ATOM   261  C  CB  . THR A 1 39  ? -3.478  -18.526 -7.610  0.50 66.64  ? 302  THR A CB  1 
ATOM   262  O  OG1 . THR A 1 39  ? -4.410  -19.576 -7.348  0.50 65.58  ? 302  THR A OG1 1 
ATOM   263  C  CG2 . THR A 1 39  ? -2.061  -19.014 -7.401  0.50 67.64  ? 302  THR A CG2 1 
ATOM   264  N  N   . TRP A 1 40  ? -6.123  -17.494 -5.803  0.50 62.21  ? 303  TRP A N   1 
ATOM   265  C  CA  . TRP A 1 40  ? -7.576  -17.187 -5.763  0.50 61.18  ? 303  TRP A CA  1 
ATOM   266  C  C   . TRP A 1 40  ? -7.792  -15.913 -4.947  0.50 62.92  ? 303  TRP A C   1 
ATOM   267  O  O   . TRP A 1 40  ? -7.280  -15.860 -3.816  0.50 59.74  ? 303  TRP A O   1 
ATOM   268  C  CB  . TRP A 1 40  ? -8.354  -18.356 -5.155  0.50 60.16  ? 303  TRP A CB  1 
ATOM   269  C  CG  . TRP A 1 40  ? -8.586  -19.511 -6.077  0.50 59.08  ? 303  TRP A CG  1 
ATOM   270  C  CD1 . TRP A 1 40  ? -7.754  -20.568 -6.305  0.50 59.53  ? 303  TRP A CD1 1 
ATOM   271  C  CD2 . TRP A 1 40  ? -9.755  -19.740 -6.880  0.50 58.53  ? 303  TRP A CD2 1 
ATOM   272  N  NE1 . TRP A 1 40  ? -8.320  -21.431 -7.203  0.50 60.45  ? 303  TRP A NE1 1 
ATOM   273  C  CE2 . TRP A 1 40  ? -9.548  -20.950 -7.573  0.50 58.83  ? 303  TRP A CE2 1 
ATOM   274  C  CE3 . TRP A 1 40  ? -10.949 -19.040 -7.084  0.50 58.28  ? 303  TRP A CE3 1 
ATOM   275  C  CZ2 . TRP A 1 40  ? -10.492 -21.472 -8.454  0.50 58.01  ? 303  TRP A CZ2 1 
ATOM   276  C  CZ3 . TRP A 1 40  ? -11.880 -19.556 -7.956  0.50 60.24  ? 303  TRP A CZ3 1 
ATOM   277  C  CH2 . TRP A 1 40  ? -11.653 -20.755 -8.629  0.50 58.20  ? 303  TRP A CH2 1 
ATOM   278  N  N   . ALA A 1 41  ? -8.515  -14.933 -5.498  0.50 63.27  ? 304  ALA A N   1 
ATOM   279  C  CA  . ALA A 1 41  ? -8.838  -13.708 -4.732  0.50 65.31  ? 304  ALA A CA  1 
ATOM   280  C  C   . ALA A 1 41  ? -9.789  -14.074 -3.593  0.50 66.31  ? 304  ALA A C   1 
ATOM   281  O  O   . ALA A 1 41  ? -10.780 -14.772 -3.854  0.50 65.40  ? 304  ALA A O   1 
ATOM   282  C  CB  . ALA A 1 41  ? -9.424  -12.650 -5.629  0.50 64.63  ? 304  ALA A CB  1 
ATOM   283  N  N   . TYR A 1 42  ? -9.483  -13.617 -2.379  1.00 68.65  ? 305  TYR A N   1 
ATOM   284  C  CA  . TYR A 1 42  ? -10.294 -13.968 -1.188  1.00 69.62  ? 305  TYR A CA  1 
ATOM   285  C  C   . TYR A 1 42  ? -11.153 -12.770 -0.818  1.00 71.44  ? 305  TYR A C   1 
ATOM   286  O  O   . TYR A 1 42  ? -10.690 -11.627 -0.953  1.00 82.47  ? 305  TYR A O   1 
ATOM   287  C  CB  . TYR A 1 42  ? -9.379  -14.337 -0.023  1.00 72.14  ? 305  TYR A CB  1 
ATOM   288  C  CG  . TYR A 1 42  ? -10.063 -14.522 1.305   1.00 71.94  ? 305  TYR A CG  1 
ATOM   289  C  CD1 . TYR A 1 42  ? -10.760 -15.682 1.592   1.00 67.86  ? 305  TYR A CD1 1 
ATOM   290  C  CD2 . TYR A 1 42  ? -9.988  -13.548 2.286   1.00 71.56  ? 305  TYR A CD2 1 
ATOM   291  C  CE1 . TYR A 1 42  ? -11.381 -15.865 2.815   1.00 71.34  ? 305  TYR A CE1 1 
ATOM   292  C  CE2 . TYR A 1 42  ? -10.600 -13.716 3.515   1.00 71.42  ? 305  TYR A CE2 1 
ATOM   293  C  CZ  . TYR A 1 42  ? -11.300 -14.878 3.779   1.00 69.28  ? 305  TYR A CZ  1 
ATOM   294  O  OH  . TYR A 1 42  ? -11.909 -15.049 4.985   1.00 69.49  ? 305  TYR A OH  1 
ATOM   295  N  N   . HIS A 1 43  ? -12.365 -13.030 -0.354  1.00 71.06  ? 306  HIS A N   1 
ATOM   296  C  CA  . HIS A 1 43  ? -13.280 -11.903 -0.081  1.00 73.04  ? 306  HIS A CA  1 
ATOM   297  C  C   . HIS A 1 43  ? -13.741 -11.970 1.374   1.00 70.98  ? 306  HIS A C   1 
ATOM   298  O  O   . HIS A 1 43  ? -13.655 -10.942 2.051   1.00 86.50  ? 306  HIS A O   1 
ATOM   299  C  CB  . HIS A 1 43  ? -14.410 -11.916 -1.113  1.00 70.07  ? 306  HIS A CB  1 
ATOM   300  C  CG  . HIS A 1 43  ? -13.933 -11.682 -2.506  1.00 64.71  ? 306  HIS A CG  1 
ATOM   301  N  ND1 . HIS A 1 43  ? -13.685 -10.418 -2.996  1.00 62.71  ? 306  HIS A ND1 1 
ATOM   302  C  CD2 . HIS A 1 43  ? -13.652 -12.538 -3.510  1.00 60.34  ? 306  HIS A CD2 1 
ATOM   303  C  CE1 . HIS A 1 43  ? -13.275 -10.505 -4.243  1.00 56.44  ? 306  HIS A CE1 1 
ATOM   304  N  NE2 . HIS A 1 43  ? -13.245 -11.794 -4.581  1.00 59.06  ? 306  HIS A NE2 1 
ATOM   305  N  N   . GLY A 1 44  ? -14.192 -13.134 1.825   1.00 68.15  ? 307  GLY A N   1 
ATOM   306  C  CA  . GLY A 1 44  ? -14.714 -13.245 3.195   1.00 67.37  ? 307  GLY A CA  1 
ATOM   307  C  C   . GLY A 1 44  ? -15.074 -14.662 3.570   1.00 70.44  ? 307  GLY A C   1 
ATOM   308  O  O   . GLY A 1 44  ? -14.898 -15.554 2.731   1.00 67.71  ? 307  GLY A O   1 
ATOM   309  N  N   . SER A 1 45  ? -15.570 -14.849 4.791   1.00 73.11  ? 308  SER A N   1 
ATOM   310  C  CA  . SER A 1 45  ? -15.932 -16.198 5.280   1.00 76.28  ? 308  SER A CA  1 
ATOM   311  C  C   . SER A 1 45  ? -17.251 -16.151 6.050   1.00 78.10  ? 308  SER A C   1 
ATOM   312  O  O   . SER A 1 45  ? -17.720 -15.041 6.320   1.00 83.73  ? 308  SER A O   1 
ATOM   313  C  CB  . SER A 1 45  ? -14.831 -16.763 6.127   1.00 79.97  ? 308  SER A CB  1 
ATOM   314  O  OG  . SER A 1 45  ? -13.591 -16.715 5.438   1.00 75.38  ? 308  SER A OG  1 
ATOM   315  N  N   . TYR A 1 46  ? -17.805 -17.311 6.386   1.00 78.66  ? 309  TYR A N   1 
ATOM   316  C  CA  . TYR A 1 46  ? -19.105 -17.438 7.107   1.00 85.22  ? 309  TYR A CA  1 
ATOM   317  C  C   . TYR A 1 46  ? -19.317 -18.897 7.565   1.00 87.83  ? 309  TYR A C   1 
ATOM   318  O  O   . TYR A 1 46  ? -18.711 -19.827 6.986   1.00 91.38  ? 309  TYR A O   1 
ATOM   319  C  CB  . TYR A 1 46  ? -20.250 -16.859 6.257   1.00 84.09  ? 309  TYR A CB  1 
ATOM   320  C  CG  . TYR A 1 46  ? -20.819 -17.734 5.161   1.00 82.16  ? 309  TYR A CG  1 
ATOM   321  C  CD1 . TYR A 1 46  ? -21.656 -18.799 5.460   1.00 81.04  ? 309  TYR A CD1 1 
ATOM   322  C  CD2 . TYR A 1 46  ? -20.593 -17.459 3.819   1.00 81.38  ? 309  TYR A CD2 1 
ATOM   323  C  CE1 . TYR A 1 46  ? -22.203 -19.596 4.467   1.00 84.02  ? 309  TYR A CE1 1 
ATOM   324  C  CE2 . TYR A 1 46  ? -21.133 -18.248 2.812   1.00 79.57  ? 309  TYR A CE2 1 
ATOM   325  C  CZ  . TYR A 1 46  ? -21.947 -19.320 3.137   1.00 80.25  ? 309  TYR A CZ  1 
ATOM   326  O  OH  . TYR A 1 46  ? -22.501 -20.115 2.173   1.00 76.48  ? 309  TYR A OH  1 
ATOM   327  N  N   . GLU A 1 47  ? -20.176 -19.089 8.574   1.00 86.70  ? 310  GLU A N   1 
ATOM   328  C  CA  . GLU A 1 47  ? -20.349 -20.350 9.351   1.00 92.52  ? 310  GLU A CA  1 
ATOM   329  C  C   . GLU A 1 47  ? -21.202 -21.355 8.565   1.00 92.78  ? 310  GLU A C   1 
ATOM   330  O  O   . GLU A 1 47  ? -22.246 -20.944 8.019   1.00 99.34  ? 310  GLU A O   1 
ATOM   331  C  CB  . GLU A 1 47  ? -20.990 -20.027 10.709  1.00 101.83 ? 310  GLU A CB  1 
ATOM   332  C  CG  . GLU A 1 47  ? -21.364 -21.243 11.553  1.00 103.87 ? 310  GLU A CG  1 
ATOM   333  C  CD  . GLU A 1 47  ? -21.836 -20.901 12.959  1.00 105.62 ? 310  GLU A CD  1 
ATOM   334  O  OE1 . GLU A 1 47  ? -23.036 -21.106 13.252  1.00 107.77 ? 310  GLU A OE1 1 
ATOM   335  O  OE2 . GLU A 1 47  ? -21.004 -20.422 13.757  1.00 107.14 ? 310  GLU A OE2 1 
ATOM   336  N  N   . THR A 1 48  ? -20.783 -22.628 8.546   1.00 88.64  ? 311  THR A N   1 
ATOM   337  C  CA  . THR A 1 48  ? -21.518 -23.779 7.949   1.00 90.62  ? 311  THR A CA  1 
ATOM   338  C  C   . THR A 1 48  ? -21.120 -25.045 8.714   1.00 97.12  ? 311  THR A C   1 
ATOM   339  O  O   . THR A 1 48  ? -20.222 -24.938 9.565   1.00 101.04 ? 311  THR A O   1 
ATOM   340  C  CB  . THR A 1 48  ? -21.244 -23.890 6.441   1.00 93.91  ? 311  THR A CB  1 
ATOM   341  O  OG1 . THR A 1 48  ? -19.874 -23.559 6.207   1.00 95.97  ? 311  THR A OG1 1 
ATOM   342  C  CG2 . THR A 1 48  ? -22.115 -22.977 5.605   1.00 94.61  ? 311  THR A CG2 1 
ATOM   343  N  N   . LYS A 1 49  ? -21.757 -26.187 8.436   1.00 104.33 ? 312  LYS A N   1 
ATOM   344  C  CA  . LYS A 1 49  ? -21.480 -27.471 9.138   1.00 109.25 ? 312  LYS A CA  1 
ATOM   345  C  C   . LYS A 1 49  ? -22.041 -28.641 8.324   1.00 110.90 ? 312  LYS A C   1 
ATOM   346  O  O   . LYS A 1 49  ? -23.245 -28.915 8.463   1.00 111.24 ? 312  LYS A O   1 
ATOM   347  C  CB  . LYS A 1 49  ? -22.095 -27.456 10.543  1.00 114.04 ? 312  LYS A CB  1 
ATOM   348  C  CG  . LYS A 1 49  ? -21.118 -27.239 11.695  1.00 118.42 ? 312  LYS A CG  1 
ATOM   349  C  CD  . LYS A 1 49  ? -21.731 -27.470 13.068  1.00 116.03 ? 312  LYS A CD  1 
ATOM   350  C  CE  . LYS A 1 49  ? -22.675 -26.366 13.497  1.00 113.86 ? 312  LYS A CE  1 
ATOM   351  N  NZ  . LYS A 1 49  ? -23.403 -26.717 14.739  1.00 110.37 ? 312  LYS A NZ  1 
ATOM   352  N  N   . GLN A 1 50  ? -21.193 -29.311 7.535   1.00 108.21 ? 313  GLN A N   1 
ATOM   353  C  CA  . GLN A 1 50  ? -21.584 -30.463 6.677   1.00 116.08 ? 313  GLN A CA  1 
ATOM   354  C  C   . GLN A 1 50  ? -20.342 -31.067 6.004   1.00 123.31 ? 313  GLN A C   1 
ATOM   355  O  O   . GLN A 1 50  ? -19.226 -30.576 6.281   1.00 125.58 ? 313  GLN A O   1 
ATOM   356  C  CB  . GLN A 1 50  ? -22.615 -30.017 5.635   1.00 122.05 ? 313  GLN A CB  1 
ATOM   357  C  CG  . GLN A 1 50  ? -24.060 -30.114 6.114   1.00 124.20 ? 313  GLN A CG  1 
ATOM   358  C  CD  . GLN A 1 50  ? -25.051 -30.380 5.007   1.00 125.30 ? 313  GLN A CD  1 
ATOM   359  O  OE1 . GLN A 1 50  ? -24.715 -30.896 3.942   1.00 122.46 ? 313  GLN A OE1 1 
ATOM   360  N  NE2 . GLN A 1 50  ? -26.301 -30.031 5.259   1.00 127.45 ? 313  GLN A NE2 1 
ATOM   361  N  N   . THR A 1 51  ? -20.540 -32.102 5.170   1.00 123.45 ? 314  THR A N   1 
ATOM   362  C  CA  . THR A 1 51  ? -19.494 -32.788 4.356   1.00 120.07 ? 314  THR A CA  1 
ATOM   363  C  C   . THR A 1 51  ? -18.819 -31.761 3.440   1.00 118.59 ? 314  THR A C   1 
ATOM   364  O  O   . THR A 1 51  ? -19.561 -30.910 2.905   1.00 112.91 ? 314  THR A O   1 
ATOM   365  C  CB  . THR A 1 51  ? -20.075 -33.941 3.520   1.00 120.37 ? 314  THR A CB  1 
ATOM   366  O  OG1 . THR A 1 51  ? -21.034 -34.654 4.301   1.00 120.17 ? 314  THR A OG1 1 
ATOM   367  C  CG2 . THR A 1 51  ? -19.022 -34.911 3.027   1.00 114.30 ? 314  THR A CG2 1 
ATOM   368  N  N   . ALA A 1 54  ? -18.918 -38.202 1.669   0.50 69.94  ? 317  ALA A N   1 
ATOM   369  C  CA  . ALA A 1 54  ? -19.259 -38.973 0.449   0.50 69.87  ? 317  ALA A CA  1 
ATOM   370  C  C   . ALA A 1 54  ? -18.268 -40.132 0.275   0.50 67.76  ? 317  ALA A C   1 
ATOM   371  O  O   . ALA A 1 54  ? -17.098 -39.867 -0.076  0.50 68.38  ? 317  ALA A O   1 
ATOM   372  C  CB  . ALA A 1 54  ? -19.261 -38.061 -0.756  0.50 69.09  ? 317  ALA A CB  1 
ATOM   373  N  N   . SER A 1 55  ? -18.730 -41.366 0.510   0.50 63.59  ? 318  SER A N   1 
ATOM   374  C  CA  . SER A 1 55  ? -17.947 -42.622 0.361   0.50 58.45  ? 318  SER A CA  1 
ATOM   375  C  C   . SER A 1 55  ? -18.497 -43.455 -0.805  0.50 53.16  ? 318  SER A C   1 
ATOM   376  O  O   . SER A 1 55  ? -19.674 -43.277 -1.177  0.50 49.88  ? 318  SER A O   1 
ATOM   377  C  CB  . SER A 1 55  ? -17.940 -43.416 1.645   0.50 59.72  ? 318  SER A CB  1 
ATOM   378  O  OG  . SER A 1 55  ? -19.242 -43.895 1.952   0.50 58.53  ? 318  SER A OG  1 
ATOM   379  N  N   . SER A 1 56  ? -17.654 -44.322 -1.367  0.50 48.87  ? 319  SER A N   1 
ATOM   380  C  CA  . SER A 1 56  ? -18.013 -45.311 -2.413  0.50 46.69  ? 319  SER A CA  1 
ATOM   381  C  C   . SER A 1 56  ? -18.568 -46.578 -1.746  0.50 43.12  ? 319  SER A C   1 
ATOM   382  O  O   . SER A 1 56  ? -17.794 -47.281 -1.052  0.50 40.93  ? 319  SER A O   1 
ATOM   383  C  CB  . SER A 1 56  ? -16.816 -45.608 -3.280  0.50 50.24  ? 319  SER A CB  1 
ATOM   384  O  OG  . SER A 1 56  ? -15.673 -45.879 -2.485  0.50 52.05  ? 319  SER A OG  1 
ATOM   385  N  N   . MET A 1 57  ? -19.848 -46.883 -1.980  1.00 37.68  ? 320  MET A N   1 
ATOM   386  C  CA  . MET A 1 57  ? -20.536 -48.016 -1.310  1.00 32.02  ? 320  MET A CA  1 
ATOM   387  C  C   . MET A 1 57  ? -20.357 -49.265 -2.191  1.00 26.18  ? 320  MET A C   1 
ATOM   388  O  O   . MET A 1 57  ? -20.232 -49.099 -3.415  1.00 27.73  ? 320  MET A O   1 
ATOM   389  C  CB  . MET A 1 57  ? -21.999 -47.640 -1.201  1.00 31.92  ? 320  MET A CB  1 
ATOM   390  C  CG  . MET A 1 57  ? -22.220 -46.214 -0.644  1.00 34.83  ? 320  MET A CG  1 
ATOM   391  S  SD  . MET A 1 57  ? -21.562 -46.090 1.030   1.00 39.01  ? 320  MET A SD  1 
ATOM   392  C  CE  . MET A 1 57  ? -22.767 -47.103 1.883   1.00 33.49  ? 320  MET A CE  1 
ATOM   393  N  N   . VAL A 1 58  ? -20.344 -50.455 -1.625  1.00 22.96  ? 321  VAL A N   1 
ATOM   394  C  CA  . VAL A 1 58  ? -20.163 -51.696 -2.427  1.00 22.12  ? 321  VAL A CA  1 
ATOM   395  C  C   . VAL A 1 58  ? -21.511 -52.181 -2.975  1.00 22.43  ? 321  VAL A C   1 
ATOM   396  O  O   . VAL A 1 58  ? -22.490 -52.185 -2.224  1.00 23.96  ? 321  VAL A O   1 
ATOM   397  C  CB  . VAL A 1 58  ? -19.406 -52.777 -1.666  1.00 24.16  ? 321  VAL A CB  1 
ATOM   398  C  CG1 . VAL A 1 58  ? -19.299 -54.071 -2.485  1.00 23.64  ? 321  VAL A CG1 1 
ATOM   399  C  CG2 . VAL A 1 58  ? -18.020 -52.240 -1.304  1.00 28.68  ? 321  VAL A CG2 1 
ATOM   400  N  N   . ASN A 1 59  ? -21.527 -52.580 -4.246  1.00 20.00  ? 322  ASN A N   1 
ATOM   401  C  CA  . ASN A 1 59  ? -22.644 -53.297 -4.883  1.00 19.06  ? 322  ASN A CA  1 
ATOM   402  C  C   . ASN A 1 59  ? -22.552 -54.791 -4.536  1.00 19.76  ? 322  ASN A C   1 
ATOM   403  O  O   . ASN A 1 59  ? -21.708 -55.517 -5.117  1.00 19.67  ? 322  ASN A O   1 
ATOM   404  C  CB  . ASN A 1 59  ? -22.679 -53.069 -6.380  1.00 18.97  ? 322  ASN A CB  1 
ATOM   405  C  CG  . ASN A 1 59  ? -23.906 -53.675 -7.041  1.00 19.28  ? 322  ASN A CG  1 
ATOM   406  O  OD1 . ASN A 1 59  ? -24.332 -54.784 -6.720  1.00 20.00  ? 322  ASN A OD1 1 
ATOM   407  N  ND2 . ASN A 1 59  ? -24.453 -52.951 -8.016  1.00 21.84  ? 322  ASN A ND2 1 
ATOM   408  N  N   . GLY A 1 60  ? -23.404 -55.255 -3.636  1.00 21.28  ? 323  GLY A N   1 
ATOM   409  C  CA  . GLY A 1 60  ? -23.363 -56.644 -3.150  1.00 19.65  ? 323  GLY A CA  1 
ATOM   410  C  C   . GLY A 1 60  ? -23.747 -57.679 -4.177  1.00 19.29  ? 323  GLY A C   1 
ATOM   411  O  O   . GLY A 1 60  ? -23.297 -58.822 -4.083  1.00 21.27  ? 323  GLY A O   1 
ATOM   412  N  N   . VAL A 1 61  ? -24.625 -57.345 -5.144  1.00 19.16  ? 324  VAL A N   1 
ATOM   413  C  CA  . VAL A 1 61  ? -24.989 -58.296 -6.199  1.00 19.56  ? 324  VAL A CA  1 
ATOM   414  C  C   . VAL A 1 61  ? -23.752 -58.574 -7.053  1.00 18.03  ? 324  VAL A C   1 
ATOM   415  O  O   . VAL A 1 61  ? -23.459 -59.741 -7.302  1.00 18.73  ? 324  VAL A O   1 
ATOM   416  C  CB  . VAL A 1 61  ? -26.190 -57.772 -7.028  1.00 19.89  ? 324  VAL A CB  1 
ATOM   417  C  CG1 . VAL A 1 61  ? -26.381 -58.559 -8.271  1.00 21.44  ? 324  VAL A CG1 1 
ATOM   418  C  CG2 . VAL A 1 61  ? -27.446 -57.752 -6.166  1.00 23.43  ? 324  VAL A CG2 1 
ATOM   419  N  N   . VAL A 1 62  ? -23.019 -57.543 -7.474  1.00 17.71  ? 325  VAL A N   1 
ATOM   420  C  CA  . VAL A 1 62  ? -21.820 -57.752 -8.329  1.00 17.37  ? 325  VAL A CA  1 
ATOM   421  C  C   . VAL A 1 62  ? -20.737 -58.456 -7.478  1.00 17.84  ? 325  VAL A C   1 
ATOM   422  O  O   . VAL A 1 62  ? -20.093 -59.393 -7.964  1.00 17.90  ? 325  VAL A O   1 
ATOM   423  C  CB  . VAL A 1 62  ? -21.318 -56.448 -8.962  1.00 18.58  ? 325  VAL A CB  1 
ATOM   424  C  CG1 . VAL A 1 62  ? -20.036 -56.657 -9.763  1.00 17.70  ? 325  VAL A CG1 1 
ATOM   425  C  CG2 . VAL A 1 62  ? -22.355 -55.813 -9.864  1.00 19.18  ? 325  VAL A CG2 1 
ATOM   426  N  N   . ARG A 1 63  ? -20.527 -58.031 -6.238  1.00 18.06  ? 326  ARG A N   1 
ATOM   427  C  CA  . ARG A 1 63  ? -19.432 -58.608 -5.430  1.00 17.47  ? 326  ARG A CA  1 
ATOM   428  C  C   . ARG A 1 63  ? -19.719 -60.090 -5.158  1.00 17.45  ? 326  ARG A C   1 
ATOM   429  O  O   . ARG A 1 63  ? -18.792 -60.923 -5.302  1.00 18.05  ? 326  ARG A O   1 
ATOM   430  C  CB  . ARG A 1 63  ? -19.188 -57.829 -4.154  1.00 17.43  ? 326  ARG A CB  1 
ATOM   431  C  CG  . ARG A 1 63  ? -18.141 -58.522 -3.286  1.00 17.88  ? 326  ARG A CG  1 
ATOM   432  C  CD  . ARG A 1 63  ? -17.427 -57.598 -2.310  1.00 18.51  ? 326  ARG A CD  1 
ATOM   433  N  NE  . ARG A 1 63  ? -18.309 -57.134 -1.252  1.00 19.60  ? 326  ARG A NE  1 
ATOM   434  C  CZ  . ARG A 1 63  ? -17.958 -56.328 -0.260  1.00 18.35  ? 326  ARG A CZ  1 
ATOM   435  N  NH1 . ARG A 1 63  ? -16.704 -55.978 -0.116  1.00 19.31  ? 326  ARG A NH1 1 
ATOM   436  N  NH2 . ARG A 1 63  ? -18.856 -55.875 0.608   1.00 20.01  ? 326  ARG A NH2 1 
ATOM   437  N  N   . LEU A 1 64  ? -20.955 -60.482 -4.830  1.00 17.47  ? 327  LEU A N   1 
ATOM   438  C  CA  . LEU A 1 64  ? -21.220 -61.917 -4.569  1.00 18.64  ? 327  LEU A CA  1 
ATOM   439  C  C   . LEU A 1 64  ? -20.985 -62.771 -5.817  1.00 19.38  ? 327  LEU A C   1 
ATOM   440  O  O   . LEU A 1 64  ? -20.699 -63.955 -5.657  1.00 20.95  ? 327  LEU A O   1 
ATOM   441  C  CB  . LEU A 1 64  ? -22.646 -62.135 -4.050  1.00 18.96  ? 327  LEU A CB  1 
ATOM   442  C  CG  . LEU A 1 64  ? -22.871 -61.774 -2.589  1.00 20.42  ? 327  LEU A CG  1 
ATOM   443  C  CD1 . LEU A 1 64  ? -24.362 -61.939 -2.264  1.00 21.28  ? 327  LEU A CD1 1 
ATOM   444  C  CD2 . LEU A 1 64  ? -22.023 -62.621 -1.651  1.00 21.45  ? 327  LEU A CD2 1 
ATOM   445  N  N   . LEU A 1 65  ? -21.054 -62.208 -7.017  1.00 18.08  ? 328  LEU A N   1 
ATOM   446  C  CA  . LEU A 1 65  ? -20.847 -62.971 -8.289  1.00 19.35  ? 328  LEU A CA  1 
ATOM   447  C  C   . LEU A 1 65  ? -19.438 -62.806 -8.853  1.00 17.26  ? 328  LEU A C   1 
ATOM   448  O  O   . LEU A 1 65  ? -19.170 -63.359 -9.907  1.00 18.60  ? 328  LEU A O   1 
ATOM   449  C  CB  . LEU A 1 65  ? -21.952 -62.539 -9.263  1.00 19.55  ? 328  LEU A CB  1 
ATOM   450  C  CG  . LEU A 1 65  ? -23.359 -62.953 -8.773  1.00 20.41  ? 328  LEU A CG  1 
ATOM   451  C  CD1 . LEU A 1 65  ? -24.459 -62.355 -9.648  1.00 20.38  ? 328  LEU A CD1 1 
ATOM   452  C  CD2 . LEU A 1 65  ? -23.493 -64.456 -8.779  1.00 22.11  ? 328  LEU A CD2 1 
ATOM   453  N  N   . THR A 1 66  ? -18.542 -62.169 -8.128  1.00 17.17  ? 329  THR A N   1 
ATOM   454  C  CA  . THR A 1 66  ? -17.127 -62.012 -8.532  1.00 17.75  ? 329  THR A CA  1 
ATOM   455  C  C   . THR A 1 66  ? -16.203 -62.389 -7.354  1.00 16.92  ? 329  THR A C   1 
ATOM   456  O  O   . THR A 1 66  ? -15.187 -61.700 -7.105  1.00 15.81  ? 329  THR A O   1 
ATOM   457  C  CB  . THR A 1 66  ? -16.865 -60.594 -9.078  1.00 18.69  ? 329  THR A CB  1 
ATOM   458  O  OG1 . THR A 1 66  ? -17.247 -59.568 -8.142  1.00 17.15  ? 329  THR A OG1 1 
ATOM   459  C  CG2 . THR A 1 66  ? -17.569 -60.348 -10.399 1.00 19.06  ? 329  THR A CG2 1 
ATOM   460  N  N   . LYS A 1 67  ? -16.451 -63.505 -6.704  1.00 16.84  ? 330  LYS A N   1 
ATOM   461  C  CA  . LYS A 1 67  ? -15.706 -63.925 -5.492  1.00 18.34  ? 330  LYS A CA  1 
ATOM   462  C  C   . LYS A 1 67  ? -14.189 -63.974 -5.702  1.00 17.89  ? 330  LYS A C   1 
ATOM   463  O  O   . LYS A 1 67  ? -13.458 -63.566 -4.781  1.00 17.85  ? 330  LYS A O   1 
ATOM   464  C  CB  . LYS A 1 67  ? -16.260 -65.245 -4.965  1.00 20.55  ? 330  LYS A CB  1 
ATOM   465  C  CG  . LYS A 1 67  ? -15.690 -65.690 -3.629  1.00 20.87  ? 330  LYS A CG  1 
ATOM   466  C  CD  . LYS A 1 67  ? -16.300 -67.023 -3.187  1.00 24.14  ? 330  LYS A CD  1 
ATOM   467  C  CE  . LYS A 1 67  ? -15.944 -67.272 -1.722  1.00 29.81  ? 330  LYS A CE  1 
ATOM   468  N  NZ  . LYS A 1 67  ? -16.321 -68.631 -1.263  1.00 30.57  ? 330  LYS A NZ  1 
ATOM   469  N  N   . PRO A 1 68  ? -13.623 -64.479 -6.813  1.00 16.83  ? 331  PRO A N   1 
ATOM   470  C  CA  . PRO A 1 68  ? -12.154 -64.587 -6.932  1.00 17.48  ? 331  PRO A CA  1 
ATOM   471  C  C   . PRO A 1 68  ? -11.463 -63.229 -6.727  1.00 19.82  ? 331  PRO A C   1 
ATOM   472  O  O   . PRO A 1 68  ? -10.299 -63.194 -6.250  1.00 20.52  ? 331  PRO A O   1 
ATOM   473  C  CB  . PRO A 1 68  ? -11.918 -65.028 -8.373  1.00 18.55  ? 331  PRO A CB  1 
ATOM   474  C  CG  . PRO A 1 68  ? -13.158 -65.842 -8.698  1.00 19.35  ? 331  PRO A CG  1 
ATOM   475  C  CD  . PRO A 1 68  ? -14.296 -65.129 -7.956  1.00 18.60  ? 331  PRO A CD  1 
ATOM   476  N  N   . TRP A 1 69  ? -12.162 -62.114 -7.033  1.00 18.04  ? 332  TRP A N   1 
ATOM   477  C  CA  . TRP A 1 69  ? -11.575 -60.749 -6.968  1.00 17.50  ? 332  TRP A CA  1 
ATOM   478  C  C   . TRP A 1 69  ? -11.609 -60.227 -5.526  1.00 17.55  ? 332  TRP A C   1 
ATOM   479  O  O   . TRP A 1 69  ? -11.053 -59.145 -5.260  1.00 19.22  ? 332  TRP A O   1 
ATOM   480  C  CB  . TRP A 1 69  ? -12.225 -59.825 -8.003  1.00 17.97  ? 332  TRP A CB  1 
ATOM   481  C  CG  . TRP A 1 69  ? -11.864 -60.235 -9.391  1.00 17.20  ? 332  TRP A CG  1 
ATOM   482  C  CD1 . TRP A 1 69  ? -10.775 -59.802 -10.078 1.00 17.94  ? 332  TRP A CD1 1 
ATOM   483  C  CD2 . TRP A 1 69  ? -12.477 -61.262 -10.208 1.00 18.14  ? 332  TRP A CD2 1 
ATOM   484  N  NE1 . TRP A 1 69  ? -10.673 -60.454 -11.275 1.00 18.22  ? 332  TRP A NE1 1 
ATOM   485  C  CE2 . TRP A 1 69  ? -11.701 -61.352 -11.387 1.00 20.26  ? 332  TRP A CE2 1 
ATOM   486  C  CE3 . TRP A 1 69  ? -13.593 -62.094 -10.096 1.00 19.56  ? 332  TRP A CE3 1 
ATOM   487  C  CZ2 . TRP A 1 69  ? -12.034 -62.208 -12.430 1.00 21.55  ? 332  TRP A CZ2 1 
ATOM   488  C  CZ3 . TRP A 1 69  ? -13.916 -62.948 -11.129 1.00 19.99  ? 332  TRP A CZ3 1 
ATOM   489  C  CH2 . TRP A 1 69  ? -13.119 -63.035 -12.268 1.00 21.22  ? 332  TRP A CH2 1 
ATOM   490  N  N   . ASP A 1 70  ? -12.231 -60.957 -4.580  1.00 18.25  ? 333  ASP A N   1 
ATOM   491  C  CA  . ASP A 1 70  ? -12.282 -60.535 -3.154  1.00 17.69  ? 333  ASP A CA  1 
ATOM   492  C  C   . ASP A 1 70  ? -10.879 -60.522 -2.508  1.00 18.33  ? 333  ASP A C   1 
ATOM   493  O  O   . ASP A 1 70  ? -10.729 -59.876 -1.459  1.00 21.38  ? 333  ASP A O   1 
ATOM   494  C  CB  . ASP A 1 70  ? -13.182 -61.445 -2.297  1.00 18.50  ? 333  ASP A CB  1 
ATOM   495  C  CG  . ASP A 1 70  ? -14.664 -61.355 -2.633  1.00 19.02  ? 333  ASP A CG  1 
ATOM   496  O  OD1 . ASP A 1 70  ? -15.051 -60.418 -3.395  1.00 20.04  ? 333  ASP A OD1 1 
ATOM   497  O  OD2 . ASP A 1 70  ? -15.427 -62.180 -2.085  1.00 18.77  ? 333  ASP A OD2 1 
ATOM   498  N  N   . ILE A 1 71  ? -9.890  -61.176 -3.115  1.00 18.80  ? 334  ILE A N   1 
ATOM   499  C  CA  . ILE A 1 71  ? -8.509  -61.271 -2.596  1.00 19.68  ? 334  ILE A CA  1 
ATOM   500  C  C   . ILE A 1 71  ? -7.535  -60.560 -3.553  1.00 22.99  ? 334  ILE A C   1 
ATOM   501  O  O   . ILE A 1 71  ? -6.270  -60.766 -3.394  1.00 23.59  ? 334  ILE A O   1 
ATOM   502  C  CB  . ILE A 1 71  ? -8.117  -62.731 -2.340  1.00 21.37  ? 334  ILE A CB  1 
ATOM   503  C  CG1 . ILE A 1 71  ? -8.153  -63.589 -3.609  1.00 24.34  ? 334  ILE A CG1 1 
ATOM   504  C  CG2 . ILE A 1 71  ? -8.986  -63.317 -1.232  1.00 24.08  ? 334  ILE A CG2 1 
ATOM   505  C  CD1 . ILE A 1 71  ? -7.377  -64.894 -3.518  1.00 27.53  ? 334  ILE A CD1 1 
ATOM   506  N  N   . ILE A 1 72  ? -8.015  -59.714 -4.454  1.00 20.63  ? 335  ILE A N   1 
ATOM   507  C  CA  . ILE A 1 72  ? -7.137  -58.962 -5.411  1.00 20.13  ? 335  ILE A CA  1 
ATOM   508  C  C   . ILE A 1 72  ? -7.138  -57.516 -4.964  1.00 22.69  ? 335  ILE A C   1 
ATOM   509  O  O   . ILE A 1 72  ? -8.110  -56.772 -5.179  1.00 21.76  ? 335  ILE A O   1 
ATOM   510  C  CB  . ILE A 1 72  ? -7.644  -59.130 -6.857  1.00 24.11  ? 335  ILE A CB  1 
ATOM   511  C  CG1 . ILE A 1 72  ? -7.699  -60.604 -7.288  1.00 29.80  ? 335  ILE A CG1 1 
ATOM   512  C  CG2 . ILE A 1 72  ? -6.874  -58.217 -7.827  1.00 22.00  ? 335  ILE A CG2 1 
ATOM   513  C  CD1 . ILE A 1 72  ? -6.543  -61.154 -8.010  1.00 35.67  ? 335  ILE A CD1 1 
ATOM   514  N  N   . PRO A 1 73  ? -6.031  -57.012 -4.372  1.00 23.71  ? 336  PRO A N   1 
ATOM   515  C  CA  . PRO A 1 73  ? -6.019  -55.646 -3.843  1.00 25.78  ? 336  PRO A CA  1 
ATOM   516  C  C   . PRO A 1 73  ? -6.314  -54.548 -4.862  1.00 24.27  ? 336  PRO A C   1 
ATOM   517  O  O   . PRO A 1 73  ? -6.977  -53.594 -4.487  1.00 24.64  ? 336  PRO A O   1 
ATOM   518  C  CB  . PRO A 1 73  ? -4.587  -55.464 -3.312  1.00 28.98  ? 336  PRO A CB  1 
ATOM   519  C  CG  . PRO A 1 73  ? -4.159  -56.879 -3.006  1.00 31.00  ? 336  PRO A CG  1 
ATOM   520  C  CD  . PRO A 1 73  ? -4.796  -57.760 -4.078  1.00 26.20  ? 336  PRO A CD  1 
ATOM   521  N  N   . MET A 1 74  ? -5.907  -54.719 -6.120  1.00 22.66  ? 337  MET A N   1 
ATOM   522  C  CA  . MET A 1 74  ? -6.212  -53.680 -7.133  1.00 27.08  ? 337  MET A CA  1 
ATOM   523  C  C   . MET A 1 74  ? -7.737  -53.522 -7.291  1.00 29.94  ? 337  MET A C   1 
ATOM   524  O  O   . MET A 1 74  ? -8.172  -52.416 -7.593  1.00 29.35  ? 337  MET A O   1 
ATOM   525  C  CB  . MET A 1 74  ? -5.577  -53.988 -8.484  1.00 30.93  ? 337  MET A CB  1 
ATOM   526  C  CG  . MET A 1 74  ? -4.051  -53.878 -8.446  1.00 40.00  ? 337  MET A CG  1 
ATOM   527  S  SD  . MET A 1 74  ? -3.485  -52.128 -8.192  1.00 46.37  ? 337  MET A SD  1 
ATOM   528  C  CE  . MET A 1 74  ? -4.605  -51.214 -9.248  1.00 45.42  ? 337  MET A CE  1 
ATOM   529  N  N   . VAL A 1 75  ? -8.527  -54.569 -7.042  1.00 20.80  ? 338  VAL A N   1 
ATOM   530  C  CA  . VAL A 1 75  ? -10.019 -54.462 -7.037  1.00 20.70  ? 338  VAL A CA  1 
ATOM   531  C  C   . VAL A 1 75  ? -10.498 -53.949 -5.678  1.00 21.39  ? 338  VAL A C   1 
ATOM   532  O  O   . VAL A 1 75  ? -11.265 -53.008 -5.654  1.00 23.97  ? 338  VAL A O   1 
ATOM   533  C  CB  . VAL A 1 75  ? -10.679 -55.828 -7.347  1.00 19.36  ? 338  VAL A CB  1 
ATOM   534  C  CG1 . VAL A 1 75  ? -12.170 -55.784 -7.036  1.00 20.62  ? 338  VAL A CG1 1 
ATOM   535  C  CG2 . VAL A 1 75  ? -10.410 -56.259 -8.773  1.00 20.67  ? 338  VAL A CG2 1 
ATOM   536  N  N   . THR A 1 76  ? -10.104 -54.585 -4.588  1.00 21.53  ? 339  THR A N   1 
ATOM   537  C  CA  . THR A 1 76  ? -10.704 -54.332 -3.257  1.00 21.73  ? 339  THR A CA  1 
ATOM   538  C  C   . THR A 1 76  ? -10.361 -52.931 -2.749  1.00 23.41  ? 339  THR A C   1 
ATOM   539  O  O   . THR A 1 76  ? -11.240 -52.332 -2.152  1.00 24.00  ? 339  THR A O   1 
ATOM   540  C  CB  . THR A 1 76  ? -10.305 -55.403 -2.243  1.00 24.01  ? 339  THR A CB  1 
ATOM   541  O  OG1 . THR A 1 76  ? -8.893  -55.336 -2.054  1.00 23.08  ? 339  THR A OG1 1 
ATOM   542  C  CG2 . THR A 1 76  ? -10.760 -56.783 -2.702  1.00 24.73  ? 339  THR A CG2 1 
ATOM   543  N  N   . GLN A 1 77  ? -9.173  -52.395 -3.080  1.00 23.17  ? 340  GLN A N   1 
ATOM   544  C  CA  . GLN A 1 77  ? -8.748  -51.037 -2.633  1.00 25.94  ? 340  GLN A CA  1 
ATOM   545  C  C   . GLN A 1 77  ? -9.561  -49.944 -3.339  1.00 24.75  ? 340  GLN A C   1 
ATOM   546  O  O   . GLN A 1 77  ? -9.655  -48.860 -2.771  1.00 25.42  ? 340  GLN A O   1 
ATOM   547  C  CB  . GLN A 1 77  ? -7.238  -50.877 -2.772  1.00 28.09  ? 340  GLN A CB  1 
ATOM   548  C  CG  . GLN A 1 77  ? -6.488  -52.051 -2.194  1.00 39.98  ? 340  GLN A CG  1 
ATOM   549  C  CD  . GLN A 1 77  ? -5.874  -51.849 -0.836  1.00 53.17  ? 340  GLN A CD  1 
ATOM   550  O  OE1 . GLN A 1 77  ? -6.415  -51.138 0.006   1.00 61.80  ? 340  GLN A OE1 1 
ATOM   551  N  NE2 . GLN A 1 77  ? -4.746  -52.517 -0.622  1.00 59.26  ? 340  GLN A NE2 1 
ATOM   552  N  N   . MET A 1 78  ? -10.138 -50.208 -4.516  1.00 24.44  ? 341  MET A N   1 
ATOM   553  C  CA  . MET A 1 78  ? -10.900 -49.173 -5.273  1.00 26.30  ? 341  MET A CA  1 
ATOM   554  C  C   . MET A 1 78  ? -12.114 -48.707 -4.481  1.00 24.17  ? 341  MET A C   1 
ATOM   555  O  O   . MET A 1 78  ? -12.543 -47.569 -4.679  1.00 24.54  ? 341  MET A O   1 
ATOM   556  C  CB  . MET A 1 78  ? -11.371 -49.653 -6.652  1.00 27.53  ? 341  MET A CB  1 
ATOM   557  C  CG  . MET A 1 78  ? -10.235 -49.926 -7.605  1.00 36.84  ? 341  MET A CG  1 
ATOM   558  S  SD  . MET A 1 78  ? -10.841 -50.271 -9.327  1.00 37.89  ? 341  MET A SD  1 
ATOM   559  C  CE  . MET A 1 78  ? -12.194 -49.136 -9.292  1.00 25.67  ? 341  MET A CE  1 
ATOM   560  N  N   . ALA A 1 79  ? -12.672 -49.552 -3.604  1.00 24.02  ? 342  ALA A N   1 
ATOM   561  C  CA  . ALA A 1 79  ? -13.894 -49.231 -2.831  1.00 26.88  ? 342  ALA A CA  1 
ATOM   562  C  C   . ALA A 1 79  ? -13.544 -48.503 -1.524  1.00 28.14  ? 342  ALA A C   1 
ATOM   563  O  O   . ALA A 1 79  ? -14.473 -48.010 -0.875  1.00 29.12  ? 342  ALA A O   1 
ATOM   564  C  CB  . ALA A 1 79  ? -14.674 -50.526 -2.594  1.00 30.17  ? 342  ALA A CB  1 
ATOM   565  N  N   . MET A 1 80  ? -12.272 -48.385 -1.137  1.00 29.12  ? 343  MET A N   1 
ATOM   566  C  CA  . MET A 1 80  ? -11.879 -47.779 0.177   1.00 32.96  ? 343  MET A CA  1 
ATOM   567  C  C   . MET A 1 80  ? -11.627 -46.260 0.064   1.00 47.55  ? 343  MET A C   1 
ATOM   568  O  O   . MET A 1 80  ? -11.399 -45.756 -1.062  1.00 44.86  ? 343  MET A O   1 
ATOM   569  C  CB  . MET A 1 80  ? -10.605 -48.436 0.723   1.00 29.94  ? 343  MET A CB  1 
ATOM   570  C  CG  . MET A 1 80  ? -10.693 -49.939 0.761   1.00 31.21  ? 343  MET A CG  1 
ATOM   571  S  SD  . MET A 1 80  ? -12.066 -50.537 1.842   1.00 36.52  ? 343  MET A SD  1 
ATOM   572  C  CE  . MET A 1 80  ? -11.388 -50.273 3.486   1.00 35.28  ? 343  MET A CE  1 
ATOM   573  N  N   . THR A 1 81  ? -11.575 -45.571 1.214   1.00 62.00  ? 344  THR A N   1 
ATOM   574  C  CA  . THR A 1 81  ? -11.137 -44.160 1.348   1.00 63.30  ? 344  THR A CA  1 
ATOM   575  C  C   . THR A 1 81  ? -12.299 -43.180 1.253   1.00 56.98  ? 344  THR A C   1 
ATOM   576  O  O   . THR A 1 81  ? -13.425 -43.576 1.624   1.00 62.45  ? 344  THR A O   1 
ATOM   577  N  N   . LYS A 1 93  ? -5.905  -30.152 -4.519  0.50 109.72 ? 356  LYS A N   1 
ATOM   578  C  CA  . LYS A 1 93  ? -6.330  -28.728 -4.442  0.50 109.71 ? 356  LYS A CA  1 
ATOM   579  C  C   . LYS A 1 93  ? -5.080  -27.849 -4.291  0.50 111.59 ? 356  LYS A C   1 
ATOM   580  O  O   . LYS A 1 93  ? -5.229  -26.649 -3.980  0.50 112.17 ? 356  LYS A O   1 
ATOM   581  C  CB  . LYS A 1 93  ? -7.330  -28.545 -3.294  0.50 107.27 ? 356  LYS A CB  1 
ATOM   582  C  CG  . LYS A 1 93  ? -8.157  -27.266 -3.344  0.50 104.19 ? 356  LYS A CG  1 
ATOM   583  C  CD  . LYS A 1 93  ? -7.543  -26.120 -2.571  0.50 101.35 ? 356  LYS A CD  1 
ATOM   584  C  CE  . LYS A 1 93  ? -7.751  -26.257 -1.079  0.50 99.34  ? 356  LYS A CE  1 
ATOM   585  N  NZ  . LYS A 1 93  ? -9.128  -26.704 -0.763  0.50 98.35  ? 356  LYS A NZ  1 
ATOM   586  N  N   . GLU A 1 94  ? -3.898  -28.440 -4.508  0.50 112.66 ? 357  GLU A N   1 
ATOM   587  C  CA  . GLU A 1 94  ? -2.585  -27.741 -4.569  0.50 112.58 ? 357  GLU A CA  1 
ATOM   588  C  C   . GLU A 1 94  ? -2.302  -27.325 -6.017  0.50 111.48 ? 357  GLU A C   1 
ATOM   589  O  O   . GLU A 1 94  ? -1.286  -26.640 -6.243  0.50 109.81 ? 357  GLU A O   1 
ATOM   590  C  CB  . GLU A 1 94  ? -1.459  -28.642 -4.058  0.50 113.77 ? 357  GLU A CB  1 
ATOM   591  C  CG  . GLU A 1 94  ? -1.209  -28.529 -2.565  0.50 114.93 ? 357  GLU A CG  1 
ATOM   592  C  CD  . GLU A 1 94  ? -2.327  -29.067 -1.690  0.50 116.53 ? 357  GLU A CD  1 
ATOM   593  O  OE1 . GLU A 1 94  ? -2.020  -29.597 -0.602  0.50 116.85 ? 357  GLU A OE1 1 
ATOM   594  O  OE2 . GLU A 1 94  ? -3.500  -28.952 -2.096  0.50 116.99 ? 357  GLU A OE2 1 
ATOM   595  N  N   . LYS A 1 95  ? -3.163  -27.744 -6.952  0.50 113.62 ? 358  LYS A N   1 
ATOM   596  C  CA  . LYS A 1 95  ? -3.053  -27.425 -8.403  0.50 112.25 ? 358  LYS A CA  1 
ATOM   597  C  C   . LYS A 1 95  ? -4.121  -26.402 -8.813  0.50 110.13 ? 358  LYS A C   1 
ATOM   598  O  O   . LYS A 1 95  ? -3.837  -25.611 -9.737  0.50 106.80 ? 358  LYS A O   1 
ATOM   599  C  CB  . LYS A 1 95  ? -3.171  -28.691 -9.258  0.50 111.97 ? 358  LYS A CB  1 
ATOM   600  C  CG  . LYS A 1 95  ? -2.998  -28.459 -10.753 0.50 110.21 ? 358  LYS A CG  1 
ATOM   601  C  CD  . LYS A 1 95  ? -2.260  -29.570 -11.459 0.50 109.95 ? 358  LYS A CD  1 
ATOM   602  C  CE  . LYS A 1 95  ? -1.567  -29.094 -12.717 0.50 110.43 ? 358  LYS A CE  1 
ATOM   603  N  NZ  . LYS A 1 95  ? -0.617  -30.106 -13.234 0.50 110.60 ? 358  LYS A NZ  1 
ATOM   604  N  N   . VAL A 1 96  ? -5.302  -26.422 -8.180  1.00 111.00 ? 359  VAL A N   1 
ATOM   605  C  CA  . VAL A 1 96  ? -6.360  -25.386 -8.417  1.00 108.53 ? 359  VAL A CA  1 
ATOM   606  C  C   . VAL A 1 96  ? -5.780  -24.033 -7.976  1.00 106.29 ? 359  VAL A C   1 
ATOM   607  O  O   . VAL A 1 96  ? -6.013  -23.040 -8.686  1.00 107.11 ? 359  VAL A O   1 
ATOM   608  C  CB  . VAL A 1 96  ? -7.703  -25.692 -7.712  1.00 104.08 ? 359  VAL A CB  1 
ATOM   609  C  CG1 . VAL A 1 96  ? -7.707  -25.287 -6.243  1.00 101.12 ? 359  VAL A CG1 1 
ATOM   610  C  CG2 . VAL A 1 96  ? -8.876  -25.039 -8.433  1.00 97.64  ? 359  VAL A CG2 1 
ATOM   611  N  N   . ASP A 1 97  ? -4.997  -24.027 -6.888  1.00 101.22 ? 360  ASP A N   1 
ATOM   612  C  CA  . ASP A 1 97  ? -4.264  -22.843 -6.360  1.00 94.72  ? 360  ASP A CA  1 
ATOM   613  C  C   . ASP A 1 97  ? -2.855  -22.799 -6.993  1.00 97.07  ? 360  ASP A C   1 
ATOM   614  O  O   . ASP A 1 97  ? -1.857  -22.864 -6.241  1.00 103.10 ? 360  ASP A O   1 
ATOM   615  C  CB  . ASP A 1 97  ? -4.275  -22.868 -4.823  1.00 87.89  ? 360  ASP A CB  1 
ATOM   616  C  CG  . ASP A 1 97  ? -4.427  -21.518 -4.132  1.00 85.26  ? 360  ASP A CG  1 
ATOM   617  O  OD1 . ASP A 1 97  ? -4.287  -20.472 -4.798  1.00 82.16  ? 360  ASP A OD1 1 
ATOM   618  O  OD2 . ASP A 1 97  ? -4.681  -21.521 -2.914  1.00 90.17  ? 360  ASP A OD2 1 
ATOM   619  N  N   . THR A 1 98  ? -2.827  -22.634 -8.325  1.00 88.65  ? 361  THR A N   1 
ATOM   620  C  CA  . THR A 1 98  ? -1.567  -22.455 -9.089  1.00 92.02  ? 361  THR A CA  1 
ATOM   621  C  C   . THR A 1 98  ? -1.869  -21.414 -10.175 1.00 92.80  ? 361  THR A C   1 
ATOM   622  O  O   . THR A 1 98  ? -3.047  -21.047 -10.291 1.00 90.13  ? 361  THR A O   1 
ATOM   623  C  CB  . THR A 1 98  ? -1.100  -23.757 -9.746  1.00 89.35  ? 361  THR A CB  1 
ATOM   624  O  OG1 . THR A 1 98  ? -2.099  -24.163 -10.682 1.00 83.77  ? 361  THR A OG1 1 
ATOM   625  C  CG2 . THR A 1 98  ? -0.830  -24.859 -8.746  1.00 85.36  ? 361  THR A CG2 1 
ATOM   626  N  N   . ARG A 1 99  ? -0.876  -20.950 -10.941 0.50 93.68  ? 362  ARG A N   1 
ATOM   627  C  CA  . ARG A 1 99  ? -1.179  -19.891 -11.943 0.50 96.17  ? 362  ARG A CA  1 
ATOM   628  C  C   . ARG A 1 99  ? -0.500  -20.203 -13.283 0.50 95.27  ? 362  ARG A C   1 
ATOM   629  O  O   . ARG A 1 99  ? 0.478   -20.973 -13.284 0.50 95.97  ? 362  ARG A O   1 
ATOM   630  C  CB  . ARG A 1 99  ? -0.741  -18.509 -11.454 0.50 98.99  ? 362  ARG A CB  1 
ATOM   631  C  CG  . ARG A 1 99  ? -1.562  -17.368 -12.037 0.50 101.65 ? 362  ARG A CG  1 
ATOM   632  C  CD  . ARG A 1 99  ? -0.787  -16.070 -12.144 0.50 104.70 ? 362  ARG A CD  1 
ATOM   633  N  NE  . ARG A 1 99  ? 0.180   -16.098 -13.233 0.50 108.10 ? 362  ARG A NE  1 
ATOM   634  C  CZ  . ARG A 1 99  ? 1.021   -15.111 -13.517 0.50 108.16 ? 362  ARG A CZ  1 
ATOM   635  N  NH1 . ARG A 1 99  ? 1.022   -14.012 -12.783 0.50 107.59 ? 362  ARG A NH1 1 
ATOM   636  N  NH2 . ARG A 1 99  ? 1.862   -15.228 -14.529 0.50 108.41 ? 362  ARG A NH2 1 
ATOM   637  N  N   . THR A 1 100 ? -1.006  -19.621 -14.375 0.50 91.19  ? 363  THR A N   1 
ATOM   638  C  CA  . THR A 1 100 ? -0.397  -19.820 -15.716 0.50 88.09  ? 363  THR A CA  1 
ATOM   639  C  C   . THR A 1 100 ? 0.030   -18.460 -16.270 0.50 85.76  ? 363  THR A C   1 
ATOM   640  O  O   . THR A 1 100 ? -0.778  -17.522 -16.193 0.50 88.92  ? 363  THR A O   1 
ATOM   641  C  CB  . THR A 1 100 ? -1.362  -20.539 -16.663 0.50 88.71  ? 363  THR A CB  1 
ATOM   642  O  OG1 . THR A 1 100 ? -1.742  -21.774 -16.055 0.50 87.37  ? 363  THR A OG1 1 
ATOM   643  C  CG2 . THR A 1 100 ? -0.762  -20.797 -18.028 0.50 88.44  ? 363  THR A CG2 1 
ATOM   644  N  N   . GLN A 1 101 ? 1.246   -18.368 -16.810 0.50 83.96  ? 364  GLN A N   1 
ATOM   645  C  CA  . GLN A 1 101 ? 1.771   -17.072 -17.319 0.50 83.32  ? 364  GLN A CA  1 
ATOM   646  C  C   . GLN A 1 101 ? 1.036   -16.671 -18.600 0.50 79.79  ? 364  GLN A C   1 
ATOM   647  O  O   . GLN A 1 101 ? 0.446   -17.552 -19.246 0.50 80.78  ? 364  GLN A O   1 
ATOM   648  C  CB  . GLN A 1 101 ? 3.279   -17.158 -17.572 0.50 83.60  ? 364  GLN A CB  1 
ATOM   649  C  CG  . GLN A 1 101 ? 3.894   -15.844 -18.032 0.50 84.87  ? 364  GLN A CG  1 
ATOM   650  C  CD  . GLN A 1 101 ? 5.396   -15.917 -18.152 0.50 85.73  ? 364  GLN A CD  1 
ATOM   651  O  OE1 . GLN A 1 101 ? 5.996   -16.984 -18.046 0.50 85.94  ? 364  GLN A OE1 1 
ATOM   652  N  NE2 . GLN A 1 101 ? 6.018   -14.770 -18.375 0.50 83.89  ? 364  GLN A NE2 1 
ATOM   653  N  N   . GLU A 1 102 ? 1.072   -15.383 -18.938 0.50 75.93  ? 365  GLU A N   1 
ATOM   654  C  CA  . GLU A 1 102 ? 0.436   -14.898 -20.185 0.50 71.42  ? 365  GLU A CA  1 
ATOM   655  C  C   . GLU A 1 102 ? 1.251   -15.399 -21.376 0.50 64.18  ? 365  GLU A C   1 
ATOM   656  O  O   . GLU A 1 102 ? 2.485   -15.260 -21.359 0.50 60.43  ? 365  GLU A O   1 
ATOM   657  C  CB  . GLU A 1 102 ? 0.377   -13.370 -20.181 0.50 75.45  ? 365  GLU A CB  1 
ATOM   658  C  CG  . GLU A 1 102 ? -0.133  -12.769 -21.477 0.50 78.71  ? 365  GLU A CG  1 
ATOM   659  C  CD  . GLU A 1 102 ? -1.645  -12.713 -21.600 0.50 81.49  ? 365  GLU A CD  1 
ATOM   660  O  OE1 . GLU A 1 102 ? -2.136  -12.017 -22.510 0.50 84.16  ? 365  GLU A OE1 1 
ATOM   661  O  OE2 . GLU A 1 102 ? -2.327  -13.360 -20.784 0.50 82.05  ? 365  GLU A OE2 1 
ATOM   662  N  N   . PRO A 1 103 ? 0.606   -15.976 -22.407 1.00 57.25  ? 366  PRO A N   1 
ATOM   663  C  CA  . PRO A 1 103 ? 1.322   -16.419 -23.592 1.00 53.26  ? 366  PRO A CA  1 
ATOM   664  C  C   . PRO A 1 103 ? 2.006   -15.259 -24.332 1.00 51.51  ? 366  PRO A C   1 
ATOM   665  O  O   . PRO A 1 103 ? 1.578   -14.147 -24.171 1.00 47.39  ? 366  PRO A O   1 
ATOM   666  C  CB  . PRO A 1 103 ? 0.202   -17.043 -24.438 1.00 52.12  ? 366  PRO A CB  1 
ATOM   667  C  CG  . PRO A 1 103 ? -0.866  -17.408 -23.442 1.00 50.72  ? 366  PRO A CG  1 
ATOM   668  C  CD  . PRO A 1 103 ? -0.824  -16.268 -22.452 1.00 55.03  ? 366  PRO A CD  1 
ATOM   669  N  N   . LYS A 1 104 ? 3.042   -15.559 -25.116 1.00 48.13  ? 367  LYS A N   1 
ATOM   670  C  CA  . LYS A 1 104 ? 3.764   -14.526 -25.907 1.00 50.67  ? 367  LYS A CA  1 
ATOM   671  C  C   . LYS A 1 104 ? 2.863   -13.974 -27.016 1.00 50.56  ? 367  LYS A C   1 
ATOM   672  O  O   . LYS A 1 104 ? 1.806   -14.564 -27.252 1.00 42.54  ? 367  LYS A O   1 
ATOM   673  C  CB  . LYS A 1 104 ? 5.045   -15.106 -26.516 1.00 54.92  ? 367  LYS A CB  1 
ATOM   674  C  CG  . LYS A 1 104 ? 6.020   -15.739 -25.533 1.00 58.24  ? 367  LYS A CG  1 
ATOM   675  C  CD  . LYS A 1 104 ? 6.219   -14.917 -24.284 1.00 63.94  ? 367  LYS A CD  1 
ATOM   676  C  CE  . LYS A 1 104 ? 7.332   -15.435 -23.399 1.00 64.50  ? 367  LYS A CE  1 
ATOM   677  N  NZ  . LYS A 1 104 ? 7.204   -14.928 -22.013 1.00 64.35  ? 367  LYS A NZ  1 
ATOM   678  N  N   . GLU A 1 105 ? 3.304   -12.918 -27.702 1.00 46.19  ? 368  GLU A N   1 
ATOM   679  C  CA  . GLU A 1 105 ? 2.470   -12.240 -28.728 1.00 49.18  ? 368  GLU A CA  1 
ATOM   680  C  C   . GLU A 1 105 ? 2.280   -13.139 -29.957 1.00 45.70  ? 368  GLU A C   1 
ATOM   681  O  O   . GLU A 1 105 ? 1.154   -13.140 -30.506 1.00 47.17  ? 368  GLU A O   1 
ATOM   682  C  CB  . GLU A 1 105 ? 3.095   -10.893 -29.110 1.00 54.29  ? 368  GLU A CB  1 
ATOM   683  C  CG  . GLU A 1 105 ? 3.093   -9.887  -27.961 1.00 63.82  ? 368  GLU A CG  1 
ATOM   684  C  CD  . GLU A 1 105 ? 1.730   -9.585  -27.349 1.00 64.34  ? 368  GLU A CD  1 
ATOM   685  O  OE1 . GLU A 1 105 ? 0.790   -9.288  -28.118 1.00 72.60  ? 368  GLU A OE1 1 
ATOM   686  O  OE2 . GLU A 1 105 ? 1.602   -9.671  -26.112 1.00 61.03  ? 368  GLU A OE2 1 
ATOM   687  N  N   . GLY A 1 106 ? 3.332   -13.842 -30.392 1.00 39.24  ? 369  GLY A N   1 
ATOM   688  C  CA  . GLY A 1 106 ? 3.259   -14.808 -31.498 1.00 39.65  ? 369  GLY A CA  1 
ATOM   689  C  C   . GLY A 1 106 ? 2.247   -15.914 -31.174 1.00 39.12  ? 369  GLY A C   1 
ATOM   690  O  O   . GLY A 1 106 ? 1.434   -16.237 -32.065 1.00 38.71  ? 369  GLY A O   1 
ATOM   691  N  N   . THR A 1 107 ? 2.263   -16.422 -29.943 1.00 37.41  ? 370  THR A N   1 
ATOM   692  C  CA  . THR A 1 107 ? 1.341   -17.507 -29.488 1.00 39.98  ? 370  THR A CA  1 
ATOM   693  C  C   . THR A 1 107 ? -0.115  -17.014 -29.511 1.00 42.11  ? 370  THR A C   1 
ATOM   694  O  O   . THR A 1 107 ? -0.975  -17.706 -30.105 1.00 38.28  ? 370  THR A O   1 
ATOM   695  C  CB  . THR A 1 107 ? 1.727   -18.023 -28.104 1.00 38.99  ? 370  THR A CB  1 
ATOM   696  O  OG1 . THR A 1 107 ? 3.141   -18.254 -28.094 1.00 41.81  ? 370  THR A OG1 1 
ATOM   697  C  CG2 . THR A 1 107 ? 0.998   -19.311 -27.752 1.00 38.85  ? 370  THR A CG2 1 
ATOM   698  N  N   . LYS A 1 108 ? -0.389  -15.867 -28.883 1.00 40.06  ? 371  LYS A N   1 
ATOM   699  C  CA  . LYS A 1 108 ? -1.720  -15.183 -28.891 1.00 39.18  ? 371  LYS A CA  1 
ATOM   700  C  C   . LYS A 1 108 ? -2.251  -15.000 -30.317 1.00 41.57  ? 371  LYS A C   1 
ATOM   701  O  O   . LYS A 1 108 ? -3.442  -15.286 -30.529 1.00 40.69  ? 371  LYS A O   1 
ATOM   702  C  CB  . LYS A 1 108 ? -1.609  -13.843 -28.161 1.00 44.95  ? 371  LYS A CB  1 
ATOM   703  C  CG  . LYS A 1 108 ? -1.426  -13.976 -26.661 1.00 47.72  ? 371  LYS A CG  1 
ATOM   704  C  CD  . LYS A 1 108 ? -1.789  -12.729 -25.872 1.00 53.38  ? 371  LYS A CD  1 
ATOM   705  C  CE  . LYS A 1 108 ? -0.658  -11.726 -25.795 1.00 58.68  ? 371  LYS A CE  1 
ATOM   706  N  NZ  . LYS A 1 108 ? -0.793  -10.870 -24.592 1.00 64.05  ? 371  LYS A NZ  1 
ATOM   707  N  N   . LYS A 1 109 ? -1.416  -14.563 -31.269 1.00 37.67  ? 372  LYS A N   1 
ATOM   708  C  CA  . LYS A 1 109 ? -1.805  -14.437 -32.694 1.00 39.83  ? 372  LYS A CA  1 
ATOM   709  C  C   . LYS A 1 109 ? -2.176  -15.810 -33.290 1.00 41.80  ? 372  LYS A C   1 
ATOM   710  O  O   . LYS A 1 109 ? -3.206  -15.882 -34.002 1.00 40.96  ? 372  LYS A O   1 
ATOM   711  C  CB  . LYS A 1 109 ? -0.667  -13.793 -33.498 1.00 45.06  ? 372  LYS A CB  1 
ATOM   712  C  CG  . LYS A 1 109 ? -1.029  -13.340 -34.905 1.00 56.11  ? 372  LYS A CG  1 
ATOM   713  C  CD  . LYS A 1 109 ? -2.058  -12.213 -34.942 1.00 65.18  ? 372  LYS A CD  1 
ATOM   714  C  CE  . LYS A 1 109 ? -1.597  -10.966 -34.219 1.00 68.60  ? 372  LYS A CE  1 
ATOM   715  N  NZ  . LYS A 1 109 ? -2.585  -9.872  -34.365 1.00 76.26  ? 372  LYS A NZ  1 
ATOM   716  N  N   . LEU A 1 110 ? -1.331  -16.837 -33.112 1.00 38.47  ? 373  LEU A N   1 
ATOM   717  C  CA  . LEU A 1 110 ? -1.582  -18.214 -33.653 1.00 37.35  ? 373  LEU A CA  1 
ATOM   718  C  C   . LEU A 1 110 ? -2.938  -18.713 -33.119 1.00 29.16  ? 373  LEU A C   1 
ATOM   719  O  O   . LEU A 1 110 ? -3.761  -19.183 -33.928 1.00 33.56  ? 373  LEU A O   1 
ATOM   720  C  CB  . LEU A 1 110 ? -0.450  -19.159 -33.231 1.00 37.11  ? 373  LEU A CB  1 
ATOM   721  C  CG  . LEU A 1 110 ? 0.899   -18.906 -33.912 1.00 36.44  ? 373  LEU A CG  1 
ATOM   722  C  CD1 . LEU A 1 110 ? 2.045   -19.543 -33.133 1.00 36.29  ? 373  LEU A CD1 1 
ATOM   723  C  CD2 . LEU A 1 110 ? 0.866   -19.399 -35.350 1.00 38.63  ? 373  LEU A CD2 1 
ATOM   724  N  N   . MET A 1 111 ? -3.172  -18.547 -31.831 1.00 30.69  ? 374  MET A N   1 
ATOM   725  C  CA  . MET A 1 111 ? -4.422  -19.037 -31.195 1.00 30.43  ? 374  MET A CA  1 
ATOM   726  C  C   . MET A 1 111 ? -5.639  -18.266 -31.754 1.00 33.47  ? 374  MET A C   1 
ATOM   727  O  O   . MET A 1 111 ? -6.660  -18.914 -32.064 1.00 30.17  ? 374  MET A O   1 
ATOM   728  C  CB  . MET A 1 111 ? -4.347  -18.926 -29.670 1.00 32.05  ? 374  MET A CB  1 
ATOM   729  C  CG  . MET A 1 111 ? -3.330  -19.888 -29.046 1.00 32.98  ? 374  MET A CG  1 
ATOM   730  S  SD  . MET A 1 111 ? -3.488  -19.999 -27.263 1.00 38.08  ? 374  MET A SD  1 
ATOM   731  C  CE  . MET A 1 111 ? -3.024  -18.342 -26.764 1.00 37.13  ? 374  MET A CE  1 
ATOM   732  N  N   . LYS A 1 112 ? -5.551  -16.947 -31.943 1.00 35.25  ? 375  LYS A N   1 
ATOM   733  C  CA  . LYS A 1 112 ? -6.726  -16.160 -32.408 1.00 35.45  ? 375  LYS A CA  1 
ATOM   734  C  C   . LYS A 1 112 ? -7.051  -16.519 -33.859 1.00 35.29  ? 375  LYS A C   1 
ATOM   735  O  O   . LYS A 1 112 ? -8.227  -16.705 -34.156 1.00 36.63  ? 375  LYS A O   1 
ATOM   736  C  CB  . LYS A 1 112 ? -6.458  -14.656 -32.307 1.00 46.45  ? 375  LYS A CB  1 
ATOM   737  C  CG  . LYS A 1 112 ? -7.490  -13.846 -31.536 1.00 54.21  ? 375  LYS A CG  1 
ATOM   738  C  CD  . LYS A 1 112 ? -7.233  -13.832 -30.043 1.00 64.09  ? 375  LYS A CD  1 
ATOM   739  C  CE  . LYS A 1 112 ? -8.374  -13.253 -29.236 1.00 66.69  ? 375  LYS A CE  1 
ATOM   740  N  NZ  . LYS A 1 112 ? -8.146  -13.406 -27.780 1.00 64.69  ? 375  LYS A NZ  1 
ATOM   741  N  N   . ILE A 1 113 ? -6.043  -16.559 -34.726 1.00 33.44  ? 376  ILE A N   1 
ATOM   742  C  CA  . ILE A 1 113 ? -6.228  -16.981 -36.148 1.00 33.40  ? 376  ILE A CA  1 
ATOM   743  C  C   . ILE A 1 113 ? -6.855  -18.379 -36.193 1.00 35.75  ? 376  ILE A C   1 
ATOM   744  O  O   . ILE A 1 113 ? -7.824  -18.598 -37.002 1.00 33.22  ? 376  ILE A O   1 
ATOM   745  C  CB  . ILE A 1 113 ? -4.909  -16.947 -36.946 1.00 33.97  ? 376  ILE A CB  1 
ATOM   746  C  CG1 . ILE A 1 113 ? -4.330  -15.533 -37.044 1.00 42.17  ? 376  ILE A CG1 1 
ATOM   747  C  CG2 . ILE A 1 113 ? -5.068  -17.527 -38.334 1.00 36.11  ? 376  ILE A CG2 1 
ATOM   748  C  CD1 . ILE A 1 113 ? -2.911  -15.533 -37.573 1.00 41.21  ? 376  ILE A CD1 1 
ATOM   749  N  N   . THR A 1 114 ? -6.277  -19.330 -35.448 1.00 32.59  ? 377  THR A N   1 
ATOM   750  C  CA  . THR A 1 114 ? -6.747  -20.745 -35.466 1.00 27.87  ? 377  THR A CA  1 
ATOM   751  C  C   . THR A 1 114 ? -8.183  -20.820 -34.933 1.00 25.82  ? 377  THR A C   1 
ATOM   752  O  O   . THR A 1 114 ? -9.023  -21.480 -35.579 1.00 28.32  ? 377  THR A O   1 
ATOM   753  C  CB  . THR A 1 114 ? -5.778  -21.655 -34.702 1.00 28.35  ? 377  THR A CB  1 
ATOM   754  O  OG1 . THR A 1 114 ? -4.517  -21.418 -35.328 1.00 26.37  ? 377  THR A OG1 1 
ATOM   755  C  CG2 . THR A 1 114 ? -6.135  -23.121 -34.820 1.00 27.16  ? 377  THR A CG2 1 
ATOM   756  N  N   . ALA A 1 115 ? -8.480  -20.147 -33.829 1.00 28.03  ? 378  ALA A N   1 
ATOM   757  C  CA  . ALA A 1 115 ? -9.829  -20.179 -33.212 1.00 30.49  ? 378  ALA A CA  1 
ATOM   758  C  C   . ALA A 1 115 ? -10.870 -19.576 -34.164 1.00 31.64  ? 378  ALA A C   1 
ATOM   759  O  O   . ALA A 1 115 ? -11.975 -20.207 -34.375 1.00 28.86  ? 378  ALA A O   1 
ATOM   760  C  CB  . ALA A 1 115 ? -9.830  -19.456 -31.908 1.00 29.92  ? 378  ALA A CB  1 
ATOM   761  N  N   . GLU A 1 116 ? -10.521 -18.455 -34.806 1.00 31.39  ? 379  GLU A N   1 
ATOM   762  C  CA  . GLU A 1 116 ? -11.442 -17.787 -35.773 1.00 35.53  ? 379  GLU A CA  1 
ATOM   763  C  C   . GLU A 1 116 ? -11.771 -18.781 -36.890 1.00 32.76  ? 379  GLU A C   1 
ATOM   764  O  O   . GLU A 1 116 ? -12.961 -19.023 -37.186 1.00 32.38  ? 379  GLU A O   1 
ATOM   765  C  CB  . GLU A 1 116 ? -10.814 -16.476 -36.295 1.00 38.24  ? 379  GLU A CB  1 
ATOM   766  C  CG  . GLU A 1 116 ? -11.694 -15.764 -37.310 1.00 46.80  ? 379  GLU A CG  1 
ATOM   767  C  CD  . GLU A 1 116 ? -11.151 -14.447 -37.857 1.00 50.90  ? 379  GLU A CD  1 
ATOM   768  O  OE1 . GLU A 1 116 ? -9.961  -14.163 -37.630 1.00 49.62  ? 379  GLU A OE1 1 
ATOM   769  O  OE2 . GLU A 1 116 ? -11.929 -13.716 -38.521 1.00 67.68  ? 379  GLU A OE2 1 
ATOM   770  N  N   . TRP A 1 117 ? -10.755 -19.424 -37.451 1.00 28.34  ? 380  TRP A N   1 
ATOM   771  C  CA  . TRP A 1 117 ? -10.919 -20.399 -38.535 1.00 27.81  ? 380  TRP A CA  1 
ATOM   772  C  C   . TRP A 1 117 ? -11.790 -21.581 -38.039 1.00 29.16  ? 380  TRP A C   1 
ATOM   773  O  O   . TRP A 1 117 ? -12.628 -22.081 -38.803 1.00 29.50  ? 380  TRP A O   1 
ATOM   774  C  CB  . TRP A 1 117 ? -9.540  -20.851 -38.994 1.00 30.95  ? 380  TRP A CB  1 
ATOM   775  C  CG  . TRP A 1 117 ? -9.630  -21.891 -40.042 1.00 27.14  ? 380  TRP A CG  1 
ATOM   776  C  CD1 . TRP A 1 117 ? -9.787  -21.685 -41.373 1.00 28.89  ? 380  TRP A CD1 1 
ATOM   777  C  CD2 . TRP A 1 117 ? -9.616  -23.315 -39.842 1.00 31.39  ? 380  TRP A CD2 1 
ATOM   778  N  NE1 . TRP A 1 117 ? -9.812  -22.877 -42.023 1.00 30.80  ? 380  TRP A NE1 1 
ATOM   779  C  CE2 . TRP A 1 117 ? -9.705  -23.903 -41.113 1.00 29.22  ? 380  TRP A CE2 1 
ATOM   780  C  CE3 . TRP A 1 117 ? -9.470  -24.144 -38.727 1.00 31.31  ? 380  TRP A CE3 1 
ATOM   781  C  CZ2 . TRP A 1 117 ? -9.711  -25.287 -41.305 1.00 33.33  ? 380  TRP A CZ2 1 
ATOM   782  C  CZ3 . TRP A 1 117 ? -9.450  -25.506 -38.919 1.00 28.08  ? 380  TRP A CZ3 1 
ATOM   783  C  CH2 . TRP A 1 117 ? -9.607  -26.076 -40.178 1.00 29.17  ? 380  TRP A CH2 1 
ATOM   784  N  N   . LEU A 1 118 ? -11.552 -22.051 -36.812 1.00 28.43  ? 381  LEU A N   1 
ATOM   785  C  CA  . LEU A 1 118 ? -12.177 -23.314 -36.333 1.00 27.27  ? 381  LEU A CA  1 
ATOM   786  C  C   . LEU A 1 118 ? -13.671 -23.094 -36.065 1.00 25.45  ? 381  LEU A C   1 
ATOM   787  O  O   . LEU A 1 118 ? -14.463 -23.936 -36.513 1.00 26.67  ? 381  LEU A O   1 
ATOM   788  C  CB  . LEU A 1 118 ? -11.436 -23.810 -35.090 1.00 29.01  ? 381  LEU A CB  1 
ATOM   789  C  CG  . LEU A 1 118 ? -11.880 -25.185 -34.591 1.00 29.03  ? 381  LEU A CG  1 
ATOM   790  C  CD1 . LEU A 1 118 ? -11.751 -26.232 -35.683 1.00 30.02  ? 381  LEU A CD1 1 
ATOM   791  C  CD2 . LEU A 1 118 ? -11.058 -25.567 -33.368 1.00 31.75  ? 381  LEU A CD2 1 
ATOM   792  N  N   . TRP A 1 119 ? -14.059 -21.990 -35.431 1.00 27.58  ? 382  TRP A N   1 
ATOM   793  C  CA  . TRP A 1 119 ? -15.510 -21.686 -35.223 1.00 29.76  ? 382  TRP A CA  1 
ATOM   794  C  C   . TRP A 1 119 ? -16.230 -21.575 -36.569 1.00 31.65  ? 382  TRP A C   1 
ATOM   795  O  O   . TRP A 1 119 ? -17.309 -22.176 -36.735 1.00 32.46  ? 382  TRP A O   1 
ATOM   796  C  CB  . TRP A 1 119 ? -15.710 -20.432 -34.401 1.00 30.64  ? 382  TRP A CB  1 
ATOM   797  C  CG  . TRP A 1 119 ? -15.474 -20.603 -32.942 1.00 27.64  ? 382  TRP A CG  1 
ATOM   798  C  CD1 . TRP A 1 119 ? -14.637 -19.852 -32.189 1.00 27.13  ? 382  TRP A CD1 1 
ATOM   799  C  CD2 . TRP A 1 119 ? -16.098 -21.539 -32.038 1.00 26.50  ? 382  TRP A CD2 1 
ATOM   800  N  NE1 . TRP A 1 119 ? -14.701 -20.229 -30.876 1.00 25.85  ? 382  TRP A NE1 1 
ATOM   801  C  CE2 . TRP A 1 119 ? -15.590 -21.262 -30.758 1.00 24.80  ? 382  TRP A CE2 1 
ATOM   802  C  CE3 . TRP A 1 119 ? -17.046 -22.562 -32.164 1.00 27.34  ? 382  TRP A CE3 1 
ATOM   803  C  CZ2 . TRP A 1 119 ? -15.928 -22.012 -29.630 1.00 24.04  ? 382  TRP A CZ2 1 
ATOM   804  C  CZ3 . TRP A 1 119 ? -17.408 -23.280 -31.042 1.00 26.60  ? 382  TRP A CZ3 1 
ATOM   805  C  CH2 . TRP A 1 119 ? -16.853 -23.006 -29.794 1.00 24.81  ? 382  TRP A CH2 1 
ATOM   806  N  N   . LYS A 1 120 ? -15.598 -20.948 -37.568 1.00 33.35  ? 383  LYS A N   1 
ATOM   807  C  CA  . LYS A 1 120 ? -16.186 -20.903 -38.924 1.00 32.58  ? 383  LYS A CA  1 
ATOM   808  C  C   . LYS A 1 120 ? -16.342 -22.300 -39.493 1.00 33.13  ? 383  LYS A C   1 
ATOM   809  O  O   . LYS A 1 120 ? -17.416 -22.561 -40.055 1.00 30.55  ? 383  LYS A O   1 
ATOM   810  C  CB  . LYS A 1 120 ? -15.388 -20.034 -39.900 1.00 40.87  ? 383  LYS A CB  1 
ATOM   811  C  CG  . LYS A 1 120 ? -15.438 -18.556 -39.568 1.00 47.65  ? 383  LYS A CG  1 
ATOM   812  C  CD  . LYS A 1 120 ? -14.906 -17.644 -40.650 1.00 56.39  ? 383  LYS A CD  1 
ATOM   813  C  CE  . LYS A 1 120 ? -14.871 -16.202 -40.178 1.00 59.39  ? 383  LYS A CE  1 
ATOM   814  N  NZ  . LYS A 1 120 ? -13.580 -15.568 -40.533 1.00 67.51  ? 383  LYS A NZ  1 
ATOM   815  N  N   . GLU A 1 121 ? -15.345 -23.188 -39.406 1.00 28.88  ? 384  GLU A N   1 
ATOM   816  C  CA  . GLU A 1 121 ? -15.511 -24.551 -39.957 1.00 29.68  ? 384  GLU A CA  1 
ATOM   817  C  C   . GLU A 1 121 ? -16.638 -25.267 -39.217 1.00 27.90  ? 384  GLU A C   1 
ATOM   818  O  O   . GLU A 1 121 ? -17.358 -26.030 -39.870 1.00 30.91  ? 384  GLU A O   1 
ATOM   819  C  CB  . GLU A 1 121 ? -14.270 -25.447 -39.794 1.00 31.87  ? 384  GLU A CB  1 
ATOM   820  C  CG  . GLU A 1 121 ? -13.143 -25.016 -40.638 1.00 39.02  ? 384  GLU A CG  1 
ATOM   821  C  CD  . GLU A 1 121 ? -13.390 -25.047 -42.134 1.00 37.75  ? 384  GLU A CD  1 
ATOM   822  O  OE1 . GLU A 1 121 ? -13.840 -26.099 -42.683 1.00 37.85  ? 384  GLU A OE1 1 
ATOM   823  O  OE2 . GLU A 1 121 ? -13.053 -24.023 -42.744 1.00 44.79  ? 384  GLU A OE2 1 
ATOM   824  N  N   . LEU A 1 122 ? -16.688 -25.140 -37.889 1.00 26.69  ? 385  LEU A N   1 
ATOM   825  C  CA  . LEU A 1 122 ? -17.662 -25.925 -37.092 1.00 26.39  ? 385  LEU A CA  1 
ATOM   826  C  C   . LEU A 1 122 ? -19.074 -25.412 -37.436 1.00 28.71  ? 385  LEU A C   1 
ATOM   827  O  O   . LEU A 1 122 ? -20.043 -26.189 -37.319 1.00 25.28  ? 385  LEU A O   1 
ATOM   828  C  CB  . LEU A 1 122 ? -17.352 -25.746 -35.612 1.00 26.68  ? 385  LEU A CB  1 
ATOM   829  C  CG  . LEU A 1 122 ? -16.068 -26.449 -35.154 1.00 27.04  ? 385  LEU A CG  1 
ATOM   830  C  CD1 . LEU A 1 122 ? -15.755 -26.096 -33.716 1.00 27.78  ? 385  LEU A CD1 1 
ATOM   831  C  CD2 . LEU A 1 122 ? -16.230 -27.947 -35.326 1.00 26.72  ? 385  LEU A CD2 1 
ATOM   832  N  N   . GLY A 1 123 ? -19.151 -24.123 -37.766 1.00 29.40  ? 386  GLY A N   1 
ATOM   833  C  CA  . GLY A 1 123 ? -20.405 -23.387 -38.048 1.00 32.71  ? 386  GLY A CA  1 
ATOM   834  C  C   . GLY A 1 123 ? -20.882 -23.524 -39.485 1.00 39.26  ? 386  GLY A C   1 
ATOM   835  O  O   . GLY A 1 123 ? -22.034 -23.137 -39.736 1.00 36.92  ? 386  GLY A O   1 
ATOM   836  N  N   . LYS A 1 124 ? -20.089 -24.052 -40.420 1.00 36.30  ? 387  LYS A N   1 
ATOM   837  C  CA  . LYS A 1 124 ? -20.514 -24.171 -41.843 1.00 40.47  ? 387  LYS A CA  1 
ATOM   838  C  C   . LYS A 1 124 ? -21.823 -24.967 -41.990 1.00 42.23  ? 387  LYS A C   1 
ATOM   839  O  O   . LYS A 1 124 ? -22.661 -24.601 -42.840 1.00 39.67  ? 387  LYS A O   1 
ATOM   840  C  CB  . LYS A 1 124 ? -19.416 -24.802 -42.700 1.00 41.37  ? 387  LYS A CB  1 
ATOM   841  C  CG  . LYS A 1 124 ? -18.324 -23.851 -43.162 1.00 46.59  ? 387  LYS A CG  1 
ATOM   842  C  CD  . LYS A 1 124 ? -17.345 -24.504 -44.122 1.00 52.54  ? 387  LYS A CD  1 
ATOM   843  C  CE  . LYS A 1 124 ? -16.026 -23.774 -44.278 1.00 52.32  ? 387  LYS A CE  1 
ATOM   844  N  NZ  . LYS A 1 124 ? -14.996 -24.690 -44.839 1.00 57.31  ? 387  LYS A NZ  1 
ATOM   845  N  N   . LYS A 1 125 ? -21.990 -26.073 -41.281 1.00 34.50  ? 388  LYS A N   1 
ATOM   846  C  CA  . LYS A 1 125 ? -23.175 -26.943 -41.443 1.00 36.56  ? 388  LYS A CA  1 
ATOM   847  C  C   . LYS A 1 125 ? -24.061 -26.930 -40.192 1.00 30.70  ? 388  LYS A C   1 
ATOM   848  O  O   . LYS A 1 125 ? -24.849 -27.842 -40.063 1.00 36.59  ? 388  LYS A O   1 
ATOM   849  C  CB  . LYS A 1 125 ? -22.702 -28.352 -41.766 1.00 39.79  ? 388  LYS A CB  1 
ATOM   850  C  CG  . LYS A 1 125 ? -22.034 -28.510 -43.125 1.00 46.43  ? 388  LYS A CG  1 
ATOM   851  C  CD  . LYS A 1 125 ? -21.551 -29.942 -43.355 1.00 52.69  ? 388  LYS A CD  1 
ATOM   852  C  CE  . LYS A 1 125 ? -20.280 -30.278 -42.600 1.00 59.60  ? 388  LYS A CE  1 
ATOM   853  N  NZ  . LYS A 1 125 ? -20.147 -31.737 -42.354 1.00 65.66  ? 388  LYS A NZ  1 
ATOM   854  N  N   . LYS A 1 126 ? -23.911 -25.959 -39.294 1.00 31.62  ? 389  LYS A N   1 
ATOM   855  C  CA  . LYS A 1 126 ? -24.679 -25.897 -38.029 1.00 33.04  ? 389  LYS A CA  1 
ATOM   856  C  C   . LYS A 1 126 ? -25.161 -24.469 -37.839 1.00 36.59  ? 389  LYS A C   1 
ATOM   857  O  O   . LYS A 1 126 ? -24.451 -23.567 -38.265 1.00 39.89  ? 389  LYS A O   1 
ATOM   858  C  CB  . LYS A 1 126 ? -23.840 -26.225 -36.790 1.00 31.70  ? 389  LYS A CB  1 
ATOM   859  C  CG  . LYS A 1 126 ? -23.220 -27.609 -36.804 1.00 31.45  ? 389  LYS A CG  1 
ATOM   860  C  CD  . LYS A 1 126 ? -24.184 -28.665 -36.392 1.00 31.69  ? 389  LYS A CD  1 
ATOM   861  C  CE  . LYS A 1 126 ? -23.592 -30.044 -36.433 1.00 32.12  ? 389  LYS A CE  1 
ATOM   862  N  NZ  . LYS A 1 126 ? -24.651 -31.067 -36.398 1.00 31.87  ? 389  LYS A NZ  1 
ATOM   863  N  N   . THR A 1 127 ? -26.269 -24.299 -37.116 1.00 31.51  ? 390  THR A N   1 
ATOM   864  C  CA  . THR A 1 127 ? -26.834 -22.974 -36.780 1.00 33.43  ? 390  THR A CA  1 
ATOM   865  C  C   . THR A 1 127 ? -26.928 -22.824 -35.277 1.00 28.38  ? 390  THR A C   1 
ATOM   866  O  O   . THR A 1 127 ? -27.711 -23.515 -34.643 1.00 33.42  ? 390  THR A O   1 
ATOM   867  C  CB  . THR A 1 127 ? -28.253 -22.812 -37.365 1.00 39.65  ? 390  THR A CB  1 
ATOM   868  O  OG1 . THR A 1 127 ? -28.107 -23.033 -38.769 1.00 38.53  ? 390  THR A OG1 1 
ATOM   869  C  CG2 . THR A 1 127 ? -28.830 -21.454 -37.040 1.00 39.76  ? 390  THR A CG2 1 
ATOM   870  N  N   . PRO A 1 128 ? -26.179 -21.898 -34.656 1.00 28.60  ? 391  PRO A N   1 
ATOM   871  C  CA  . PRO A 1 128 ? -26.332 -21.657 -33.230 1.00 30.98  ? 391  PRO A CA  1 
ATOM   872  C  C   . PRO A 1 128 ? -27.797 -21.297 -32.930 1.00 34.15  ? 391  PRO A C   1 
ATOM   873  O  O   . PRO A 1 128 ? -28.446 -20.648 -33.757 1.00 35.46  ? 391  PRO A O   1 
ATOM   874  C  CB  . PRO A 1 128 ? -25.415 -20.460 -32.935 1.00 30.48  ? 391  PRO A CB  1 
ATOM   875  C  CG  . PRO A 1 128 ? -24.469 -20.413 -34.100 1.00 31.50  ? 391  PRO A CG  1 
ATOM   876  C  CD  . PRO A 1 128 ? -25.216 -20.985 -35.278 1.00 31.66  ? 391  PRO A CD  1 
ATOM   877  N  N   . ARG A 1 129 ? -28.282 -21.722 -31.770 1.00 32.56  ? 392  ARG A N   1 
ATOM   878  C  CA  . ARG A 1 129 ? -29.695 -21.528 -31.353 1.00 32.40  ? 392  ARG A CA  1 
ATOM   879  C  C   . ARG A 1 129 ? -29.787 -21.679 -29.836 1.00 42.30  ? 392  ARG A C   1 
ATOM   880  O  O   . ARG A 1 129 ? -28.890 -22.288 -29.207 1.00 33.29  ? 392  ARG A O   1 
ATOM   881  C  CB  . ARG A 1 129 ? -30.636 -22.425 -32.168 1.00 33.54  ? 392  ARG A CB  1 
ATOM   882  C  CG  . ARG A 1 129 ? -30.427 -23.931 -32.084 1.00 31.58  ? 392  ARG A CG  1 
ATOM   883  C  CD  . ARG A 1 129 ? -31.206 -24.583 -31.009 1.00 35.40  ? 392  ARG A CD  1 
ATOM   884  N  NE  . ARG A 1 129 ? -30.916 -25.987 -30.774 1.00 29.92  ? 392  ARG A NE  1 
ATOM   885  C  CZ  . ARG A 1 129 ? -31.508 -26.686 -29.826 1.00 32.05  ? 392  ARG A CZ  1 
ATOM   886  N  NH1 . ARG A 1 129 ? -32.475 -26.130 -29.117 1.00 32.39  ? 392  ARG A NH1 1 
ATOM   887  N  NH2 . ARG A 1 129 ? -31.208 -27.950 -29.626 1.00 32.93  ? 392  ARG A NH2 1 
ATOM   888  N  N   . MET A 1 130 ? -30.820 -21.075 -29.247 1.00 39.99  ? 393  MET A N   1 
ATOM   889  C  CA  . MET A 1 130 ? -31.091 -21.207 -27.808 1.00 41.74  ? 393  MET A CA  1 
ATOM   890  C  C   . MET A 1 130 ? -31.747 -22.547 -27.543 1.00 40.55  ? 393  MET A C   1 
ATOM   891  O  O   . MET A 1 130 ? -32.541 -23.028 -28.371 1.00 39.87  ? 393  MET A O   1 
ATOM   892  C  CB  . MET A 1 130 ? -31.995 -20.088 -27.295 1.00 50.34  ? 393  MET A CB  1 
ATOM   893  C  CG  . MET A 1 130 ? -31.246 -18.797 -27.116 1.00 55.77  ? 393  MET A CG  1 
ATOM   894  S  SD  . MET A 1 130 ? -32.278 -17.519 -26.372 1.00 65.23  ? 393  MET A SD  1 
ATOM   895  C  CE  . MET A 1 130 ? -33.501 -17.339 -27.671 1.00 62.46  ? 393  MET A CE  1 
ATOM   896  N  N   . CYS A 1 131 ? -31.401 -23.132 -26.409 1.00 36.71  ? 394  CYS A N   1 
ATOM   897  C  CA  . CYS A 1 131 ? -32.063 -24.323 -25.864 1.00 39.43  ? 394  CYS A CA  1 
ATOM   898  C  C   . CYS A 1 131 ? -33.204 -23.826 -24.963 1.00 41.35  ? 394  CYS A C   1 
ATOM   899  O  O   . CYS A 1 131 ? -33.160 -22.668 -24.538 1.00 44.70  ? 394  CYS A O   1 
ATOM   900  C  CB  . CYS A 1 131 ? -31.051 -25.220 -25.177 1.00 41.20  ? 394  CYS A CB  1 
ATOM   901  S  SG  . CYS A 1 131 ? -29.934 -26.042 -26.344 1.00 37.90  ? 394  CYS A SG  1 
ATOM   902  N  N   . THR A 1 132 ? -34.262 -24.613 -24.835 1.00 46.09  ? 395  THR A N   1 
ATOM   903  C  CA  . THR A 1 132 ? -35.567 -24.113 -24.337 1.00 50.60  ? 395  THR A CA  1 
ATOM   904  C  C   . THR A 1 132 ? -35.840 -24.694 -22.960 1.00 48.80  ? 395  THR A C   1 
ATOM   905  O  O   . THR A 1 132 ? -35.295 -25.756 -22.635 1.00 44.86  ? 395  THR A O   1 
ATOM   906  C  CB  . THR A 1 132 ? -36.695 -24.515 -25.288 1.00 46.01  ? 395  THR A CB  1 
ATOM   907  O  OG1 . THR A 1 132 ? -36.689 -25.940 -25.343 1.00 49.99  ? 395  THR A OG1 1 
ATOM   908  C  CG2 . THR A 1 132 ? -36.514 -23.932 -26.672 1.00 54.35  ? 395  THR A CG2 1 
ATOM   909  N  N   . ARG A 1 133 ? -36.684 -24.010 -22.183 0.50 52.35  ? 396  ARG A N   1 
ATOM   910  C  CA  . ARG A 1 133 ? -37.202 -24.492 -20.873 0.50 54.19  ? 396  ARG A CA  1 
ATOM   911  C  C   . ARG A 1 133 ? -37.790 -25.895 -21.053 0.50 54.17  ? 396  ARG A C   1 
ATOM   912  O  O   . ARG A 1 133 ? -37.584 -26.736 -20.157 0.50 57.32  ? 396  ARG A O   1 
ATOM   913  C  CB  . ARG A 1 133 ? -38.247 -23.516 -20.324 0.50 55.53  ? 396  ARG A CB  1 
ATOM   914  C  CG  . ARG A 1 133 ? -37.855 -22.055 -20.480 0.50 58.47  ? 396  ARG A CG  1 
ATOM   915  C  CD  . ARG A 1 133 ? -38.506 -21.141 -19.462 0.50 61.34  ? 396  ARG A CD  1 
ATOM   916  N  NE  . ARG A 1 133 ? -37.772 -19.891 -19.324 0.50 63.49  ? 396  ARG A NE  1 
ATOM   917  C  CZ  . ARG A 1 133 ? -38.108 -18.907 -18.499 0.50 65.84  ? 396  ARG A CZ  1 
ATOM   918  N  NH1 . ARG A 1 133 ? -39.182 -19.021 -17.737 0.50 68.91  ? 396  ARG A NH1 1 
ATOM   919  N  NH2 . ARG A 1 133 ? -37.374 -17.810 -18.444 0.50 64.93  ? 396  ARG A NH2 1 
ATOM   920  N  N   . GLU A 1 134 ? -38.466 -26.136 -22.182 1.00 54.95  ? 397  GLU A N   1 
ATOM   921  C  CA  . GLU A 1 134 ? -39.047 -27.461 -22.517 1.00 58.90  ? 397  GLU A CA  1 
ATOM   922  C  C   . GLU A 1 134 ? -37.919 -28.492 -22.575 1.00 55.92  ? 397  GLU A C   1 
ATOM   923  O  O   . GLU A 1 134 ? -38.030 -29.511 -21.899 1.00 59.04  ? 397  GLU A O   1 
ATOM   924  C  CB  . GLU A 1 134 ? -39.801 -27.410 -23.853 1.00 68.46  ? 397  GLU A CB  1 
ATOM   925  C  CG  . GLU A 1 134 ? -41.112 -26.634 -23.827 1.00 76.36  ? 397  GLU A CG  1 
ATOM   926  C  CD  . GLU A 1 134 ? -41.044 -25.126 -23.598 1.00 84.20  ? 397  GLU A CD  1 
ATOM   927  O  OE1 . GLU A 1 134 ? -39.976 -24.509 -23.869 1.00 69.75  ? 397  GLU A OE1 1 
ATOM   928  O  OE2 . GLU A 1 134 ? -42.075 -24.559 -23.147 1.00 92.21  ? 397  GLU A OE2 1 
ATOM   929  N  N   . GLU A 1 135 ? -36.853 -28.220 -23.344 1.00 58.13  ? 398  GLU A N   1 
ATOM   930  C  CA  . GLU A 1 135 ? -35.689 -29.144 -23.477 1.00 54.56  ? 398  GLU A CA  1 
ATOM   931  C  C   . GLU A 1 135 ? -35.040 -29.372 -22.113 1.00 53.04  ? 398  GLU A C   1 
ATOM   932  O  O   . GLU A 1 135 ? -34.638 -30.519 -21.839 1.00 48.72  ? 398  GLU A O   1 
ATOM   933  C  CB  . GLU A 1 135 ? -34.602 -28.583 -24.396 1.00 52.32  ? 398  GLU A CB  1 
ATOM   934  C  CG  . GLU A 1 135 ? -34.882 -28.842 -25.854 1.00 52.57  ? 398  GLU A CG  1 
ATOM   935  C  CD  . GLU A 1 135 ? -33.900 -28.171 -26.792 1.00 50.14  ? 398  GLU A CD  1 
ATOM   936  O  OE1 . GLU A 1 135 ? -33.748 -26.940 -26.699 1.00 40.42  ? 398  GLU A OE1 1 
ATOM   937  O  OE2 . GLU A 1 135 ? -33.306 -28.901 -27.617 1.00 54.84  ? 398  GLU A OE2 1 
ATOM   938  N  N   . PHE A 1 136 ? -34.863 -28.295 -21.342 1.00 50.66  ? 399  PHE A N   1 
ATOM   939  C  CA  . PHE A 1 136 ? -34.247 -28.339 -19.995 1.00 55.87  ? 399  PHE A CA  1 
ATOM   940  C  C   . PHE A 1 136 ? -35.092 -29.235 -19.074 1.00 59.98  ? 399  PHE A C   1 
ATOM   941  O  O   . PHE A 1 136 ? -34.532 -30.147 -18.408 1.00 54.78  ? 399  PHE A O   1 
ATOM   942  C  CB  . PHE A 1 136 ? -34.054 -26.937 -19.423 1.00 54.33  ? 399  PHE A CB  1 
ATOM   943  C  CG  . PHE A 1 136 ? -33.243 -26.959 -18.153 1.00 55.49  ? 399  PHE A CG  1 
ATOM   944  C  CD1 . PHE A 1 136 ? -31.874 -27.174 -18.196 1.00 54.00  ? 399  PHE A CD1 1 
ATOM   945  C  CD2 . PHE A 1 136 ? -33.854 -26.813 -16.918 1.00 56.50  ? 399  PHE A CD2 1 
ATOM   946  C  CE1 . PHE A 1 136 ? -31.123 -27.198 -17.033 1.00 49.97  ? 399  PHE A CE1 1 
ATOM   947  C  CE2 . PHE A 1 136 ? -33.105 -26.850 -15.755 1.00 51.96  ? 399  PHE A CE2 1 
ATOM   948  C  CZ  . PHE A 1 136 ? -31.743 -27.045 -15.814 1.00 56.28  ? 399  PHE A CZ  1 
ATOM   949  N  N   . THR A 1 137 ? -36.407 -28.993 -19.038 0.50 59.63  ? 400  THR A N   1 
ATOM   950  C  CA  . THR A 1 137 ? -37.379 -29.728 -18.183 0.50 62.27  ? 400  THR A CA  1 
ATOM   951  C  C   . THR A 1 137 ? -37.354 -31.221 -18.534 0.50 64.84  ? 400  THR A C   1 
ATOM   952  O  O   . THR A 1 137 ? -37.376 -32.045 -17.602 0.50 64.53  ? 400  THR A O   1 
ATOM   953  C  CB  . THR A 1 137 ? -38.795 -29.156 -18.318 0.50 60.09  ? 400  THR A CB  1 
ATOM   954  O  OG1 . THR A 1 137 ? -38.746 -27.764 -18.009 0.50 60.45  ? 400  THR A OG1 1 
ATOM   955  C  CG2 . THR A 1 137 ? -39.787 -29.848 -17.410 0.50 59.68  ? 400  THR A CG2 1 
ATOM   956  N  N   . ARG A 1 138 ? -37.300 -31.555 -19.826 0.50 69.73  ? 401  ARG A N   1 
ATOM   957  C  CA  . ARG A 1 138 ? -37.310 -32.960 -20.310 0.50 72.95  ? 401  ARG A CA  1 
ATOM   958  C  C   . ARG A 1 138 ? -36.054 -33.676 -19.799 0.50 74.60  ? 401  ARG A C   1 
ATOM   959  O  O   . ARG A 1 138 ? -36.167 -34.850 -19.399 0.50 73.92  ? 401  ARG A O   1 
ATOM   960  C  CB  . ARG A 1 138 ? -37.402 -33.007 -21.839 0.50 77.58  ? 401  ARG A CB  1 
ATOM   961  C  CG  . ARG A 1 138 ? -37.683 -34.396 -22.395 0.50 80.04  ? 401  ARG A CG  1 
ATOM   962  C  CD  . ARG A 1 138 ? -38.406 -34.353 -23.728 0.50 80.78  ? 401  ARG A CD  1 
ATOM   963  N  NE  . ARG A 1 138 ? -37.644 -33.628 -24.733 0.50 83.28  ? 401  ARG A NE  1 
ATOM   964  C  CZ  . ARG A 1 138 ? -36.923 -34.199 -25.693 0.50 83.70  ? 401  ARG A CZ  1 
ATOM   965  N  NH1 . ARG A 1 138 ? -36.870 -35.517 -25.787 0.50 83.75  ? 401  ARG A NH1 1 
ATOM   966  N  NH2 . ARG A 1 138 ? -36.264 -33.449 -26.558 0.50 82.21  ? 401  ARG A NH2 1 
ATOM   967  N  N   . LYS A 1 139 ? -34.908 -32.989 -19.799 0.50 74.64  ? 402  LYS A N   1 
ATOM   968  C  CA  . LYS A 1 139 ? -33.597 -33.556 -19.377 0.50 75.17  ? 402  LYS A CA  1 
ATOM   969  C  C   . LYS A 1 139 ? -33.615 -33.840 -17.868 0.50 77.52  ? 402  LYS A C   1 
ATOM   970  O  O   . LYS A 1 139 ? -33.030 -34.868 -17.464 0.50 78.92  ? 402  LYS A O   1 
ATOM   971  C  CB  . LYS A 1 139 ? -32.452 -32.612 -19.758 0.50 74.55  ? 402  LYS A CB  1 
ATOM   972  C  CG  . LYS A 1 139 ? -32.141 -32.552 -21.249 0.50 74.82  ? 402  LYS A CG  1 
ATOM   973  C  CD  . LYS A 1 139 ? -31.020 -31.597 -21.605 0.50 73.94  ? 402  LYS A CD  1 
ATOM   974  C  CE  . LYS A 1 139 ? -29.646 -32.199 -21.406 0.50 74.49  ? 402  LYS A CE  1 
ATOM   975  N  NZ  . LYS A 1 139 ? -29.470 -33.431 -22.211 0.50 72.94  ? 402  LYS A NZ  1 
ATOM   976  N  N   . VAL A 1 140 ? -34.249 -32.972 -17.068 1.00 77.17  ? 403  VAL A N   1 
ATOM   977  C  CA  . VAL A 1 140 ? -34.315 -33.151 -15.583 1.00 81.59  ? 403  VAL A CA  1 
ATOM   978  C  C   . VAL A 1 140 ? -35.261 -34.312 -15.220 1.00 85.49  ? 403  VAL A C   1 
ATOM   979  O  O   . VAL A 1 140 ? -34.981 -35.019 -14.227 1.00 84.27  ? 403  VAL A O   1 
ATOM   980  C  CB  . VAL A 1 140 ? -34.640 -31.853 -14.802 1.00 80.43  ? 403  VAL A CB  1 
ATOM   981  C  CG1 . VAL A 1 140 ? -33.798 -30.671 -15.261 1.00 76.07  ? 403  VAL A CG1 1 
ATOM   982  C  CG2 . VAL A 1 140 ? -36.115 -31.479 -14.788 1.00 84.91  ? 403  VAL A CG2 1 
ATOM   983  N  N   . ARG A 1 141 ? -36.325 -34.511 -16.010 0.50 86.41  ? 404  ARG A N   1 
ATOM   984  C  CA  . ARG A 1 141 ? -37.383 -35.528 -15.760 0.50 86.64  ? 404  ARG A CA  1 
ATOM   985  C  C   . ARG A 1 141 ? -36.950 -36.892 -16.310 0.50 88.06  ? 404  ARG A C   1 
ATOM   986  O  O   . ARG A 1 141 ? -37.728 -37.851 -16.163 0.50 92.17  ? 404  ARG A O   1 
ATOM   987  C  CB  . ARG A 1 141 ? -38.714 -35.086 -16.377 0.50 85.31  ? 404  ARG A CB  1 
ATOM   988  C  CG  . ARG A 1 141 ? -39.432 -34.012 -15.573 0.50 85.44  ? 404  ARG A CG  1 
ATOM   989  C  CD  . ARG A 1 141 ? -40.938 -34.189 -15.584 0.50 86.29  ? 404  ARG A CD  1 
ATOM   990  N  NE  . ARG A 1 141 ? -41.564 -33.660 -16.787 0.50 86.28  ? 404  ARG A NE  1 
ATOM   991  C  CZ  . ARG A 1 141 ? -42.094 -32.447 -16.887 0.50 86.64  ? 404  ARG A CZ  1 
ATOM   992  N  NH1 . ARG A 1 141 ? -42.071 -31.628 -15.849 0.50 85.91  ? 404  ARG A NH1 1 
ATOM   993  N  NH2 . ARG A 1 141 ? -42.648 -32.056 -18.022 0.50 87.40  ? 404  ARG A NH2 1 
ATOM   994  N  N   . SER A 1 142 ? -35.758 -36.980 -16.903 0.50 90.10  ? 405  SER A N   1 
ATOM   995  C  CA  . SER A 1 142 ? -35.148 -38.249 -17.380 0.50 94.22  ? 405  SER A CA  1 
ATOM   996  C  C   . SER A 1 142 ? -33.755 -38.416 -16.761 0.50 96.64  ? 405  SER A C   1 
ATOM   997  O  O   . SER A 1 142 ? -32.930 -39.146 -17.344 0.50 96.62  ? 405  SER A O   1 
ATOM   998  C  CB  . SER A 1 142 ? -35.107 -38.296 -18.886 0.50 95.91  ? 405  SER A CB  1 
ATOM   999  O  OG  . SER A 1 142 ? -34.775 -37.026 -19.428 0.50 96.66  ? 405  SER A OG  1 
ATOM   1000 N  N   . ASN A 1 143 ? -33.535 -37.796 -15.599 0.50 100.48 ? 406  ASN A N   1 
ATOM   1001 C  CA  . ASN A 1 143 ? -32.271 -37.988 -14.832 0.50 104.82 ? 406  ASN A CA  1 
ATOM   1002 C  C   . ASN A 1 143 ? -31.026 -37.724 -15.678 0.50 106.47 ? 406  ASN A C   1 
ATOM   1003 O  O   . ASN A 1 143 ? -30.649 -38.603 -16.473 0.50 110.26 ? 406  ASN A O   1 
ATOM   1004 C  CB  . ASN A 1 143 ? -32.213 -39.378 -14.188 0.50 106.05 ? 406  ASN A CB  1 
ATOM   1005 C  CG  . ASN A 1 143 ? -33.431 -39.684 -13.343 0.50 107.64 ? 406  ASN A CG  1 
ATOM   1006 O  OD1 . ASN A 1 143 ? -34.278 -38.819 -13.127 0.50 106.80 ? 406  ASN A OD1 1 
ATOM   1007 N  ND2 . ASN A 1 143 ? -33.529 -40.912 -12.861 0.50 108.81 ? 406  ASN A ND2 1 
ATOM   1008 N  N   . ALA A 1 144 ? -30.391 -36.571 -15.478 1.00 108.69 ? 407  ALA A N   1 
ATOM   1009 C  CA  . ALA A 1 144 ? -29.117 -36.262 -16.173 1.00 107.85 ? 407  ALA A CA  1 
ATOM   1010 C  C   . ALA A 1 144 ? -28.312 -35.315 -15.278 1.00 110.60 ? 407  ALA A C   1 
ATOM   1011 O  O   . ALA A 1 144 ? -28.917 -34.378 -14.723 1.00 108.87 ? 407  ALA A O   1 
ATOM   1012 C  CB  . ALA A 1 144 ? -29.380 -35.670 -17.532 1.00 102.84 ? 407  ALA A CB  1 
ATOM   1013 N  N   . ALA A 1 145 ? -27.007 -35.557 -15.137 0.50 104.70 ? 408  ALA A N   1 
ATOM   1014 C  CA  . ALA A 1 145 ? -26.173 -34.735 -14.233 0.50 100.16 ? 408  ALA A CA  1 
ATOM   1015 C  C   . ALA A 1 145 ? -26.157 -33.285 -14.719 0.50 99.11  ? 408  ALA A C   1 
ATOM   1016 O  O   . ALA A 1 145 ? -25.701 -33.045 -15.852 0.50 99.02  ? 408  ALA A O   1 
ATOM   1017 C  CB  . ALA A 1 145 ? -24.783 -35.312 -14.165 0.50 97.67  ? 408  ALA A CB  1 
ATOM   1018 N  N   . LEU A 1 146 ? -26.641 -32.359 -13.888 0.50 96.94  ? 409  LEU A N   1 
ATOM   1019 C  CA  . LEU A 1 146 ? -26.621 -30.918 -14.251 0.50 93.55  ? 409  LEU A CA  1 
ATOM   1020 C  C   . LEU A 1 146 ? -25.811 -30.155 -13.202 0.50 90.33  ? 409  LEU A C   1 
ATOM   1021 O  O   . LEU A 1 146 ? -26.034 -28.943 -13.062 0.50 88.48  ? 409  LEU A O   1 
ATOM   1022 C  CB  . LEU A 1 146 ? -28.057 -30.395 -14.321 0.50 93.87  ? 409  LEU A CB  1 
ATOM   1023 C  CG  . LEU A 1 146 ? -29.015 -31.209 -15.188 0.50 95.16  ? 409  LEU A CG  1 
ATOM   1024 C  CD1 . LEU A 1 146 ? -30.351 -30.499 -15.327 0.50 93.26  ? 409  LEU A CD1 1 
ATOM   1025 C  CD2 . LEU A 1 146 ? -28.415 -31.474 -16.559 0.50 95.15  ? 409  LEU A CD2 1 
ATOM   1026 N  N   . GLY A 1 147 ? -24.931 -30.850 -12.475 0.50 85.64  ? 410  GLY A N   1 
ATOM   1027 C  CA  . GLY A 1 147 ? -24.066 -30.174 -11.487 0.50 84.20  ? 410  GLY A CA  1 
ATOM   1028 C  C   . GLY A 1 147 ? -24.824 -29.075 -10.770 0.50 82.60  ? 410  GLY A C   1 
ATOM   1029 O  O   . GLY A 1 147 ? -24.313 -27.943 -10.732 0.50 78.39  ? 410  GLY A O   1 
ATOM   1030 N  N   . ALA A 1 148 ? -26.004 -29.391 -10.230 0.50 82.22  ? 411  ALA A N   1 
ATOM   1031 C  CA  . ALA A 1 148 ? -26.848 -28.352 -9.597  0.50 81.29  ? 411  ALA A CA  1 
ATOM   1032 C  C   . ALA A 1 148 ? -26.827 -28.500 -8.072  0.50 81.65  ? 411  ALA A C   1 
ATOM   1033 O  O   . ALA A 1 148 ? -26.348 -29.542 -7.587  0.50 79.31  ? 411  ALA A O   1 
ATOM   1034 C  CB  . ALA A 1 148 ? -28.250 -28.428 -10.148 0.50 78.50  ? 411  ALA A CB  1 
ATOM   1035 N  N   . ILE A 1 149 ? -27.324 -27.487 -7.354  0.50 82.29  ? 412  ILE A N   1 
ATOM   1036 C  CA  . ILE A 1 149 ? -27.343 -27.512 -5.863  0.50 83.00  ? 412  ILE A CA  1 
ATOM   1037 C  C   . ILE A 1 149 ? -28.785 -27.297 -5.397  0.50 81.61  ? 412  ILE A C   1 
ATOM   1038 O  O   . ILE A 1 149 ? -29.088 -27.716 -4.264  0.50 79.06  ? 412  ILE A O   1 
ATOM   1039 C  CB  . ILE A 1 149 ? -26.403 -26.433 -5.294  0.50 83.89  ? 412  ILE A CB  1 
ATOM   1040 C  CG1 . ILE A 1 149 ? -27.010 -25.035 -5.425  0.50 84.42  ? 412  ILE A CG1 1 
ATOM   1041 C  CG2 . ILE A 1 149 ? -25.029 -26.514 -5.939  0.50 84.37  ? 412  ILE A CG2 1 
ATOM   1042 C  CD1 . ILE A 1 149 ? -26.092 -23.926 -4.975  0.50 84.17  ? 412  ILE A CD1 1 
ATOM   1043 N  N   . TRP A 1 156 ? -37.288 -25.927 -2.930  0.50 87.57  ? 419  TRP A N   1 
ATOM   1044 C  CA  . TRP A 1 156 ? -37.659 -27.198 -3.611  0.50 88.87  ? 419  TRP A CA  1 
ATOM   1045 C  C   . TRP A 1 156 ? -36.642 -28.287 -3.253  0.50 90.33  ? 419  TRP A C   1 
ATOM   1046 O  O   . TRP A 1 156 ? -35.451 -27.954 -3.104  0.50 88.96  ? 419  TRP A O   1 
ATOM   1047 C  CB  . TRP A 1 156 ? -37.744 -26.993 -5.129  0.50 87.79  ? 419  TRP A CB  1 
ATOM   1048 C  CG  . TRP A 1 156 ? -38.424 -25.721 -5.531  0.50 84.73  ? 419  TRP A CG  1 
ATOM   1049 C  CD1 . TRP A 1 156 ? -39.758 -25.536 -5.747  0.50 84.39  ? 419  TRP A CD1 1 
ATOM   1050 C  CD2 . TRP A 1 156 ? -37.799 -24.444 -5.759  0.50 82.72  ? 419  TRP A CD2 1 
ATOM   1051 N  NE1 . TRP A 1 156 ? -40.006 -24.236 -6.095  0.50 83.47  ? 419  TRP A NE1 1 
ATOM   1052 C  CE2 . TRP A 1 156 ? -38.825 -23.543 -6.112  0.50 81.98  ? 419  TRP A CE2 1 
ATOM   1053 C  CE3 . TRP A 1 156 ? -36.481 -23.976 -5.702  0.50 81.72  ? 419  TRP A CE3 1 
ATOM   1054 C  CZ2 . TRP A 1 156 ? -38.570 -22.204 -6.403  0.50 82.21  ? 419  TRP A CZ2 1 
ATOM   1055 C  CZ3 . TRP A 1 156 ? -36.230 -22.654 -5.992  0.50 81.00  ? 419  TRP A CZ3 1 
ATOM   1056 C  CH2 . TRP A 1 156 ? -37.263 -21.782 -6.337  0.50 82.29  ? 419  TRP A CH2 1 
ATOM   1057 N  N   . LYS A 1 157 ? -37.100 -29.537 -3.132  0.50 94.69  ? 420  LYS A N   1 
ATOM   1058 C  CA  . LYS A 1 157 ? -36.255 -30.708 -2.775  0.50 97.25  ? 420  LYS A CA  1 
ATOM   1059 C  C   . LYS A 1 157 ? -35.238 -30.959 -3.895  0.50 97.58  ? 420  LYS A C   1 
ATOM   1060 O  O   . LYS A 1 157 ? -34.085 -30.501 -3.764  0.50 98.60  ? 420  LYS A O   1 
ATOM   1061 C  CB  . LYS A 1 157 ? -37.125 -31.947 -2.540  0.50 99.18  ? 420  LYS A CB  1 
ATOM   1062 C  CG  . LYS A 1 157 ? -36.375 -33.175 -2.040  0.50 99.65  ? 420  LYS A CG  1 
ATOM   1063 C  CD  . LYS A 1 157 ? -37.174 -34.458 -2.139  0.50 100.02 ? 420  LYS A CD  1 
ATOM   1064 C  CE  . LYS A 1 157 ? -38.476 -34.411 -1.367  0.50 98.94  ? 420  LYS A CE  1 
ATOM   1065 N  NZ  . LYS A 1 157 ? -39.241 -35.672 -1.511  0.50 99.23  ? 420  LYS A NZ  1 
ATOM   1066 N  N   . SER A 1 158 ? -35.661 -31.658 -4.953  0.50 95.83  ? 421  SER A N   1 
ATOM   1067 C  CA  . SER A 1 158 ? -34.828 -32.039 -6.124  0.50 92.53  ? 421  SER A CA  1 
ATOM   1068 C  C   . SER A 1 158 ? -35.154 -31.126 -7.312  0.50 91.81  ? 421  SER A C   1 
ATOM   1069 O  O   . SER A 1 158 ? -36.029 -30.246 -7.162  0.50 88.52  ? 421  SER A O   1 
ATOM   1070 C  CB  . SER A 1 158 ? -35.025 -33.496 -6.464  0.50 91.62  ? 421  SER A CB  1 
ATOM   1071 O  OG  . SER A 1 158 ? -36.405 -33.801 -6.602  0.50 90.59  ? 421  SER A OG  1 
ATOM   1072 N  N   . ALA A 1 159 ? -34.546 -31.372 -8.472  1.00 91.48  ? 422  ALA A N   1 
ATOM   1073 C  CA  . ALA A 1 159 ? -34.735 -30.472 -9.633  1.00 86.15  ? 422  ALA A CA  1 
ATOM   1074 C  C   . ALA A 1 159 ? -36.123 -30.655 -10.245 1.00 78.49  ? 422  ALA A C   1 
ATOM   1075 O  O   . ALA A 1 159 ? -36.679 -29.674 -10.755 1.00 67.41  ? 422  ALA A O   1 
ATOM   1076 C  CB  . ALA A 1 159 ? -33.659 -30.755 -10.639 1.00 89.54  ? 422  ALA A CB  1 
ATOM   1077 N  N   . ARG A 1 160 ? -36.655 -31.871 -10.185 1.00 76.58  ? 423  ARG A N   1 
ATOM   1078 C  CA  . ARG A 1 160 ? -37.976 -32.145 -10.797 1.00 79.07  ? 423  ARG A CA  1 
ATOM   1079 C  C   . ARG A 1 160 ? -39.013 -31.188 -10.194 1.00 84.63  ? 423  ARG A C   1 
ATOM   1080 O  O   . ARG A 1 160 ? -39.870 -30.695 -10.945 1.00 77.01  ? 423  ARG A O   1 
ATOM   1081 C  CB  . ARG A 1 160 ? -38.314 -33.622 -10.592 1.00 82.59  ? 423  ARG A CB  1 
ATOM   1082 C  CG  . ARG A 1 160 ? -39.182 -34.232 -11.681 1.00 88.66  ? 423  ARG A CG  1 
ATOM   1083 C  CD  . ARG A 1 160 ? -39.378 -35.716 -11.440 1.00 91.48  ? 423  ARG A CD  1 
ATOM   1084 N  NE  . ARG A 1 160 ? -38.134 -36.471 -11.487 1.00 92.77  ? 423  ARG A NE  1 
ATOM   1085 C  CZ  . ARG A 1 160 ? -37.877 -37.439 -12.359 1.00 95.31  ? 423  ARG A CZ  1 
ATOM   1086 N  NH1 . ARG A 1 160 ? -36.717 -38.070 -12.325 1.00 94.25  ? 423  ARG A NH1 1 
ATOM   1087 N  NH2 . ARG A 1 160 ? -38.785 -37.779 -13.255 1.00 95.85  ? 423  ARG A NH2 1 
ATOM   1088 N  N   . GLU A 1 161 ? -38.918 -30.910 -8.892  1.00 84.18  ? 424  GLU A N   1 
ATOM   1089 C  CA  . GLU A 1 161 ? -39.931 -30.053 -8.226  1.00 82.66  ? 424  GLU A CA  1 
ATOM   1090 C  C   . GLU A 1 161 ? -39.784 -28.611 -8.706  1.00 75.99  ? 424  GLU A C   1 
ATOM   1091 O  O   . GLU A 1 161 ? -40.810 -27.962 -8.947  1.00 74.47  ? 424  GLU A O   1 
ATOM   1092 C  CB  . GLU A 1 161 ? -39.782 -30.133 -6.707  1.00 88.45  ? 424  GLU A CB  1 
ATOM   1093 C  CG  . GLU A 1 161 ? -40.155 -31.490 -6.142  1.00 93.79  ? 424  GLU A CG  1 
ATOM   1094 C  CD  . GLU A 1 161 ? -40.219 -31.547 -4.627  1.00 96.90  ? 424  GLU A CD  1 
ATOM   1095 O  OE1 . GLU A 1 161 ? -39.901 -30.527 -3.983  1.00 95.04  ? 424  GLU A OE1 1 
ATOM   1096 O  OE2 . GLU A 1 161 ? -40.587 -32.612 -4.095  1.00 97.58  ? 424  GLU A OE2 1 
ATOM   1097 N  N   . ALA A 1 162 ? -38.548 -28.135 -8.823  1.00 72.57  ? 425  ALA A N   1 
ATOM   1098 C  CA  . ALA A 1 162 ? -38.323 -26.732 -9.219  1.00 70.38  ? 425  ALA A CA  1 
ATOM   1099 C  C   . ALA A 1 162 ? -38.844 -26.511 -10.634 1.00 67.86  ? 425  ALA A C   1 
ATOM   1100 O  O   . ALA A 1 162 ? -39.490 -25.478 -10.863 1.00 61.57  ? 425  ALA A O   1 
ATOM   1101 C  CB  . ALA A 1 162 ? -36.854 -26.418 -9.129  1.00 70.48  ? 425  ALA A CB  1 
ATOM   1102 N  N   . VAL A 1 163 ? -38.586 -27.460 -11.531 0.50 68.99  ? 426  VAL A N   1 
ATOM   1103 C  CA  . VAL A 1 163 ? -38.967 -27.286 -12.962 0.50 71.84  ? 426  VAL A CA  1 
ATOM   1104 C  C   . VAL A 1 163 ? -40.491 -27.235 -13.077 0.50 73.63  ? 426  VAL A C   1 
ATOM   1105 O  O   . VAL A 1 163 ? -40.984 -26.716 -14.093 0.50 72.77  ? 426  VAL A O   1 
ATOM   1106 C  CB  . VAL A 1 163 ? -38.367 -28.416 -13.820 0.50 71.61  ? 426  VAL A CB  1 
ATOM   1107 C  CG1 . VAL A 1 163 ? -39.317 -29.593 -13.969 0.50 70.02  ? 426  VAL A CG1 1 
ATOM   1108 C  CG2 . VAL A 1 163 ? -37.914 -27.908 -15.176 0.50 73.13  ? 426  VAL A CG2 1 
ATOM   1109 N  N   . GLU A 1 164 ? -41.201 -27.737 -12.065 1.00 77.30  ? 427  GLU A N   1 
ATOM   1110 C  CA  . GLU A 1 164 ? -42.687 -27.796 -12.131 1.00 85.54  ? 427  GLU A CA  1 
ATOM   1111 C  C   . GLU A 1 164 ? -43.301 -26.580 -11.422 1.00 86.25  ? 427  GLU A C   1 
ATOM   1112 O  O   . GLU A 1 164 ? -44.494 -26.317 -11.640 1.00 89.76  ? 427  GLU A O   1 
ATOM   1113 C  CB  . GLU A 1 164 ? -43.163 -29.125 -11.549 1.00 90.34  ? 427  GLU A CB  1 
ATOM   1114 C  CG  . GLU A 1 164 ? -42.572 -30.332 -12.254 1.00 96.17  ? 427  GLU A CG  1 
ATOM   1115 C  CD  . GLU A 1 164 ? -42.816 -31.659 -11.555 1.00 107.75 ? 427  GLU A CD  1 
ATOM   1116 O  OE1 . GLU A 1 164 ? -43.371 -31.644 -10.440 1.00 116.14 ? 427  GLU A OE1 1 
ATOM   1117 O  OE2 . GLU A 1 164 ? -42.447 -32.705 -12.126 1.00 116.83 ? 427  GLU A OE2 1 
ATOM   1118 N  N   . ASP A 1 165 ? -42.516 -25.864 -10.621 1.00 81.28  ? 428  ASP A N   1 
ATOM   1119 C  CA  . ASP A 1 165 ? -42.993 -24.657 -9.895  1.00 79.41  ? 428  ASP A CA  1 
ATOM   1120 C  C   . ASP A 1 165 ? -42.595 -23.388 -10.657 1.00 75.78  ? 428  ASP A C   1 
ATOM   1121 O  O   . ASP A 1 165 ? -41.388 -23.211 -10.922 1.00 68.06  ? 428  ASP A O   1 
ATOM   1122 C  CB  . ASP A 1 165 ? -42.440 -24.601 -8.470  1.00 80.98  ? 428  ASP A CB  1 
ATOM   1123 C  CG  . ASP A 1 165 ? -42.775 -23.302 -7.754  1.00 82.72  ? 428  ASP A CG  1 
ATOM   1124 O  OD1 . ASP A 1 165 ? -42.451 -22.227 -8.297  1.00 79.04  ? 428  ASP A OD1 1 
ATOM   1125 O  OD2 . ASP A 1 165 ? -43.341 -23.373 -6.651  1.00 91.16  ? 428  ASP A OD2 1 
ATOM   1126 N  N   . SER A 1 166 ? -43.560 -22.495 -10.894 1.00 73.98  ? 429  SER A N   1 
ATOM   1127 C  CA  . SER A 1 166 ? -43.398 -21.248 -11.687 1.00 73.09  ? 429  SER A CA  1 
ATOM   1128 C  C   . SER A 1 166 ? -42.628 -20.181 -10.906 1.00 70.44  ? 429  SER A C   1 
ATOM   1129 O  O   . SER A 1 166 ? -42.177 -19.219 -11.549 1.00 75.51  ? 429  SER A O   1 
ATOM   1130 C  CB  . SER A 1 166 ? -44.733 -20.727 -12.127 1.00 84.76  ? 429  SER A CB  1 
ATOM   1131 O  OG  . SER A 1 166 ? -45.394 -21.691 -12.932 1.00 91.90  ? 429  SER A OG  1 
ATOM   1132 N  N   . GLY A 1 167 ? -42.526 -20.315 -9.576  1.00 76.16  ? 430  GLY A N   1 
ATOM   1133 C  CA  . GLY A 1 167 ? -41.710 -19.439 -8.709  1.00 68.55  ? 430  GLY A CA  1 
ATOM   1134 C  C   . GLY A 1 167 ? -40.252 -19.479 -9.133  1.00 68.26  ? 430  GLY A C   1 
ATOM   1135 O  O   . GLY A 1 167 ? -39.659 -18.410 -9.289  1.00 61.14  ? 430  GLY A O   1 
ATOM   1136 N  N   . PHE A 1 168 ? -39.719 -20.685 -9.354  1.00 70.56  ? 431  PHE A N   1 
ATOM   1137 C  CA  . PHE A 1 168 ? -38.383 -20.953 -9.953  1.00 72.05  ? 431  PHE A CA  1 
ATOM   1138 C  C   . PHE A 1 168 ? -38.196 -20.088 -11.203 1.00 68.05  ? 431  PHE A C   1 
ATOM   1139 O  O   . PHE A 1 168 ? -37.274 -19.252 -11.240 1.00 60.90  ? 431  PHE A O   1 
ATOM   1140 C  CB  . PHE A 1 168 ? -38.235 -22.437 -10.305 1.00 79.84  ? 431  PHE A CB  1 
ATOM   1141 C  CG  . PHE A 1 168 ? -36.919 -22.815 -10.940 1.00 78.79  ? 431  PHE A CG  1 
ATOM   1142 C  CD1 . PHE A 1 168 ? -35.754 -22.848 -10.189 1.00 78.67  ? 431  PHE A CD1 1 
ATOM   1143 C  CD2 . PHE A 1 168 ? -36.850 -23.154 -12.283 1.00 81.96  ? 431  PHE A CD2 1 
ATOM   1144 C  CE1 . PHE A 1 168 ? -34.546 -23.201 -10.770 1.00 81.25  ? 431  PHE A CE1 1 
ATOM   1145 C  CE2 . PHE A 1 168 ? -35.641 -23.510 -12.864 1.00 83.14  ? 431  PHE A CE2 1 
ATOM   1146 C  CZ  . PHE A 1 168 ? -34.493 -23.532 -12.105 1.00 87.21  ? 431  PHE A CZ  1 
ATOM   1147 N  N   . TRP A 1 169 ? -39.072 -20.254 -12.197 1.00 68.27  ? 432  TRP A N   1 
ATOM   1148 C  CA  . TRP A 1 169 ? -38.911 -19.609 -13.529 1.00 63.20  ? 432  TRP A CA  1 
ATOM   1149 C  C   . TRP A 1 169 ? -38.901 -18.077 -13.381 1.00 69.39  ? 432  TRP A C   1 
ATOM   1150 O  O   . TRP A 1 169 ? -38.268 -17.417 -14.227 1.00 71.10  ? 432  TRP A O   1 
ATOM   1151 C  CB  . TRP A 1 169 ? -39.951 -20.149 -14.524 1.00 57.21  ? 432  TRP A CB  1 
ATOM   1152 C  CG  . TRP A 1 169 ? -39.698 -21.594 -14.826 1.00 56.13  ? 432  TRP A CG  1 
ATOM   1153 C  CD1 . TRP A 1 169 ? -40.452 -22.658 -14.436 1.00 58.49  ? 432  TRP A CD1 1 
ATOM   1154 C  CD2 . TRP A 1 169 ? -38.539 -22.150 -15.485 1.00 57.74  ? 432  TRP A CD2 1 
ATOM   1155 N  NE1 . TRP A 1 169 ? -39.870 -23.830 -14.836 1.00 60.20  ? 432  TRP A NE1 1 
ATOM   1156 C  CE2 . TRP A 1 169 ? -38.690 -23.553 -15.477 1.00 56.42  ? 432  TRP A CE2 1 
ATOM   1157 C  CE3 . TRP A 1 169 ? -37.399 -21.602 -16.085 1.00 57.71  ? 432  TRP A CE3 1 
ATOM   1158 C  CZ2 . TRP A 1 169 ? -37.755 -24.410 -16.058 1.00 55.23  ? 432  TRP A CZ2 1 
ATOM   1159 C  CZ3 . TRP A 1 169 ? -36.479 -22.450 -16.667 1.00 57.68  ? 432  TRP A CZ3 1 
ATOM   1160 C  CH2 . TRP A 1 169 ? -36.654 -23.835 -16.651 1.00 53.81  ? 432  TRP A CH2 1 
ATOM   1161 N  N   . GLU A 1 170 ? -39.488 -17.524 -12.310 1.00 71.20  ? 433  GLU A N   1 
ATOM   1162 C  CA  . GLU A 1 170 ? -39.504 -16.056 -12.048 1.00 70.14  ? 433  GLU A CA  1 
ATOM   1163 C  C   . GLU A 1 170 ? -38.138 -15.629 -11.495 1.00 62.81  ? 433  GLU A C   1 
ATOM   1164 O  O   . GLU A 1 170 ? -37.698 -14.496 -11.785 1.00 66.55  ? 433  GLU A O   1 
ATOM   1165 C  CB  . GLU A 1 170 ? -40.653 -15.682 -11.106 1.00 73.82  ? 433  GLU A CB  1 
ATOM   1166 C  CG  . GLU A 1 170 ? -42.026 -15.996 -11.681 1.00 80.91  ? 433  GLU A CG  1 
ATOM   1167 C  CD  . GLU A 1 170 ? -43.153 -16.038 -10.661 1.00 88.56  ? 433  GLU A CD  1 
ATOM   1168 O  OE1 . GLU A 1 170 ? -43.503 -14.957 -10.143 1.00 88.16  ? 433  GLU A OE1 1 
ATOM   1169 O  OE2 . GLU A 1 170 ? -43.673 -17.148 -10.377 1.00 84.52  ? 433  GLU A OE2 1 
ATOM   1170 N  N   . LEU A 1 171 ? -37.476 -16.498 -10.729 1.00 66.16  ? 434  LEU A N   1 
ATOM   1171 C  CA  . LEU A 1 171 ? -36.070 -16.269 -10.294 1.00 65.90  ? 434  LEU A CA  1 
ATOM   1172 C  C   . LEU A 1 171 ? -35.178 -16.322 -11.545 1.00 59.80  ? 434  LEU A C   1 
ATOM   1173 O  O   . LEU A 1 171 ? -34.439 -15.347 -11.793 1.00 51.34  ? 434  LEU A O   1 
ATOM   1174 C  CB  . LEU A 1 171 ? -35.674 -17.322 -9.253  1.00 63.50  ? 434  LEU A CB  1 
ATOM   1175 C  CG  . LEU A 1 171 ? -36.544 -17.379 -7.993  1.00 68.09  ? 434  LEU A CG  1 
ATOM   1176 C  CD1 . LEU A 1 171 ? -35.946 -18.348 -6.991  1.00 72.21  ? 434  LEU A CD1 1 
ATOM   1177 C  CD2 . LEU A 1 171 ? -36.710 -16.001 -7.358  1.00 66.98  ? 434  LEU A CD2 1 
ATOM   1178 N  N   . VAL A 1 172 ? -35.324 -17.391 -12.335 1.00 60.67  ? 435  VAL A N   1 
ATOM   1179 C  CA  . VAL A 1 172 ? -34.663 -17.578 -13.663 1.00 59.05  ? 435  VAL A CA  1 
ATOM   1180 C  C   . VAL A 1 172 ? -34.870 -16.305 -14.482 1.00 52.82  ? 435  VAL A C   1 
ATOM   1181 O  O   . VAL A 1 172 ? -33.873 -15.713 -14.933 1.00 56.78  ? 435  VAL A O   1 
ATOM   1182 C  CB  . VAL A 1 172 ? -35.198 -18.829 -14.389 1.00 63.17  ? 435  VAL A CB  1 
ATOM   1183 C  CG1 . VAL A 1 172 ? -34.620 -18.955 -15.792 1.00 65.24  ? 435  VAL A CG1 1 
ATOM   1184 C  CG2 . VAL A 1 172 ? -34.948 -20.108 -13.592 1.00 63.22  ? 435  VAL A CG2 1 
ATOM   1185 N  N   . ASP A 1 173 ? -36.121 -15.844 -14.600 1.00 62.12  ? 436  ASP A N   1 
ATOM   1186 C  CA  . ASP A 1 173 ? -36.481 -14.595 -15.332 1.00 60.38  ? 436  ASP A CA  1 
ATOM   1187 C  C   . ASP A 1 173 ? -35.696 -13.397 -14.791 1.00 55.70  ? 436  ASP A C   1 
ATOM   1188 O  O   . ASP A 1 173 ? -35.145 -12.623 -15.611 1.00 55.25  ? 436  ASP A O   1 
ATOM   1189 C  CB  . ASP A 1 173 ? -37.984 -14.305 -15.254 1.00 72.29  ? 436  ASP A CB  1 
ATOM   1190 C  CG  . ASP A 1 173 ? -38.827 -15.198 -16.148 1.00 75.40  ? 436  ASP A CG  1 
ATOM   1191 O  OD1 . ASP A 1 173 ? -38.326 -15.572 -17.231 1.00 70.72  ? 436  ASP A OD1 1 
ATOM   1192 O  OD2 . ASP A 1 173 ? -39.974 -15.527 -15.748 1.00 88.20  ? 436  ASP A OD2 1 
ATOM   1193 N  N   . LYS A 1 174 ? -35.663 -13.204 -13.471 1.00 57.01  ? 437  LYS A N   1 
ATOM   1194 C  CA  . LYS A 1 174 ? -35.013 -12.003 -12.878 1.00 58.66  ? 437  LYS A CA  1 
ATOM   1195 C  C   . LYS A 1 174 ? -33.534 -12.006 -13.277 1.00 55.88  ? 437  LYS A C   1 
ATOM   1196 O  O   . LYS A 1 174 ? -33.026 -10.946 -13.715 1.00 57.68  ? 437  LYS A O   1 
ATOM   1197 C  CB  . LYS A 1 174 ? -35.180 -11.965 -11.356 1.00 62.51  ? 437  LYS A CB  1 
ATOM   1198 C  CG  . LYS A 1 174 ? -34.628 -10.710 -10.690 1.00 67.62  ? 437  LYS A CG  1 
ATOM   1199 C  CD  . LYS A 1 174 ? -34.796 -10.673 -9.175  1.00 67.80  ? 437  LYS A CD  1 
ATOM   1200 C  CE  . LYS A 1 174 ? -33.999 -9.558  -8.531  1.00 69.71  ? 437  LYS A CE  1 
ATOM   1201 N  NZ  . LYS A 1 174 ? -34.080 -9.612  -7.052  1.00 77.12  ? 437  LYS A NZ  1 
ATOM   1202 N  N   . GLU A 1 175 ? -32.866 -13.156 -13.144 1.00 57.48  ? 438  GLU A N   1 
ATOM   1203 C  CA  . GLU A 1 175 ? -31.435 -13.316 -13.521 1.00 55.81  ? 438  GLU A CA  1 
ATOM   1204 C  C   . GLU A 1 175 ? -31.280 -13.068 -15.025 1.00 48.66  ? 438  GLU A C   1 
ATOM   1205 O  O   . GLU A 1 175 ? -30.341 -12.344 -15.421 1.00 53.69  ? 438  GLU A O   1 
ATOM   1206 C  CB  . GLU A 1 175 ? -30.935 -14.718 -13.178 1.00 60.34  ? 438  GLU A CB  1 
ATOM   1207 C  CG  . GLU A 1 175 ? -30.132 -14.769 -11.900 1.00 67.88  ? 438  GLU A CG  1 
ATOM   1208 C  CD  . GLU A 1 175 ? -28.865 -13.938 -11.938 1.00 61.70  ? 438  GLU A CD  1 
ATOM   1209 O  OE1 . GLU A 1 175 ? -27.915 -14.353 -12.592 1.00 68.53  ? 438  GLU A OE1 1 
ATOM   1210 O  OE2 . GLU A 1 175 ? -28.853 -12.868 -11.337 1.00 61.05  ? 438  GLU A OE2 1 
ATOM   1211 N  N   . ARG A 1 176 ? -32.170 -13.665 -15.824 1.00 52.94  ? 439  ARG A N   1 
ATOM   1212 C  CA  . ARG A 1 176 ? -32.142 -13.576 -17.306 1.00 49.48  ? 439  ARG A CA  1 
ATOM   1213 C  C   . ARG A 1 176 ? -32.114 -12.100 -17.711 1.00 55.72  ? 439  ARG A C   1 
ATOM   1214 O  O   . ARG A 1 176 ? -31.207 -11.723 -18.483 1.00 58.23  ? 439  ARG A O   1 
ATOM   1215 C  CB  . ARG A 1 176 ? -33.321 -14.351 -17.889 1.00 52.01  ? 439  ARG A CB  1 
ATOM   1216 C  CG  . ARG A 1 176 ? -33.295 -14.448 -19.406 1.00 51.29  ? 439  ARG A CG  1 
ATOM   1217 C  CD  . ARG A 1 176 ? -33.962 -15.714 -19.890 1.00 50.55  ? 439  ARG A CD  1 
ATOM   1218 N  NE  . ARG A 1 176 ? -34.015 -15.599 -21.332 1.00 61.80  ? 439  ARG A NE  1 
ATOM   1219 C  CZ  . ARG A 1 176 ? -34.759 -16.339 -22.138 1.00 67.71  ? 439  ARG A CZ  1 
ATOM   1220 N  NH1 . ARG A 1 176 ? -35.497 -17.322 -21.646 1.00 75.12  ? 439  ARG A NH1 1 
ATOM   1221 N  NH2 . ARG A 1 176 ? -34.714 -16.123 -23.444 1.00 61.51  ? 439  ARG A NH2 1 
ATOM   1222 N  N   . ASN A 1 177 ? -33.012 -11.271 -17.154 1.00 58.27  ? 440  ASN A N   1 
ATOM   1223 C  CA  . ASN A 1 177 ? -33.095 -9.814  -17.473 1.00 57.68  ? 440  ASN A CA  1 
ATOM   1224 C  C   . ASN A 1 177 ? -31.849 -9.085  -16.953 1.00 54.73  ? 440  ASN A C   1 
ATOM   1225 O  O   . ASN A 1 177 ? -31.370 -8.178  -17.655 1.00 54.26  ? 440  ASN A O   1 
ATOM   1226 C  CB  . ASN A 1 177 ? -34.415 -9.203  -16.983 1.00 62.54  ? 440  ASN A CB  1 
ATOM   1227 C  CG  . ASN A 1 177 ? -35.584 -9.728  -17.790 1.00 64.24  ? 440  ASN A CG  1 
ATOM   1228 O  OD1 . ASN A 1 177 ? -35.725 -9.415  -18.972 1.00 70.12  ? 440  ASN A OD1 1 
ATOM   1229 N  ND2 . ASN A 1 177 ? -36.389 -10.577 -17.183 1.00 63.91  ? 440  ASN A ND2 1 
ATOM   1230 N  N   . LEU A 1 178 ? -31.294 -9.502  -15.812 1.00 61.93  ? 441  LEU A N   1 
ATOM   1231 C  CA  . LEU A 1 178 ? -29.996 -8.983  -15.296 1.00 64.77  ? 441  LEU A CA  1 
ATOM   1232 C  C   . LEU A 1 178 ? -28.858 -9.251  -16.302 1.00 64.24  ? 441  LEU A C   1 
ATOM   1233 O  O   . LEU A 1 178 ? -28.058 -8.311  -16.557 1.00 61.36  ? 441  LEU A O   1 
ATOM   1234 C  CB  . LEU A 1 178 ? -29.723 -9.618  -13.928 1.00 74.18  ? 441  LEU A CB  1 
ATOM   1235 C  CG  . LEU A 1 178 ? -30.490 -8.988  -12.763 1.00 76.45  ? 441  LEU A CG  1 
ATOM   1236 C  CD1 . LEU A 1 178 ? -30.436 -9.867  -11.518 1.00 79.57  ? 441  LEU A CD1 1 
ATOM   1237 C  CD2 . LEU A 1 178 ? -29.952 -7.597  -12.457 1.00 79.51  ? 441  LEU A CD2 1 
ATOM   1238 N  N   . HIS A 1 179 ? -28.777 -10.460 -16.874 1.00 60.33  ? 442  HIS A N   1 
ATOM   1239 C  CA  . HIS A 1 179 ? -27.764 -10.810 -17.916 1.00 61.33  ? 442  HIS A CA  1 
ATOM   1240 C  C   . HIS A 1 179 ? -27.927 -9.926  -19.171 1.00 59.86  ? 442  HIS A C   1 
ATOM   1241 O  O   . HIS A 1 179 ? -26.893 -9.413  -19.655 1.00 63.58  ? 442  HIS A O   1 
ATOM   1242 C  CB  . HIS A 1 179 ? -27.792 -12.314 -18.255 1.00 55.74  ? 442  HIS A CB  1 
ATOM   1243 C  CG  . HIS A 1 179 ? -27.245 -13.206 -17.181 1.00 53.36  ? 442  HIS A CG  1 
ATOM   1244 N  ND1 . HIS A 1 179 ? -27.220 -14.589 -17.305 1.00 49.27  ? 442  HIS A ND1 1 
ATOM   1245 C  CD2 . HIS A 1 179 ? -26.708 -12.921 -15.976 1.00 47.58  ? 442  HIS A CD2 1 
ATOM   1246 C  CE1 . HIS A 1 179 ? -26.716 -15.108 -16.206 1.00 51.07  ? 442  HIS A CE1 1 
ATOM   1247 N  NE2 . HIS A 1 179 ? -26.393 -14.098 -15.373 1.00 48.82  ? 442  HIS A NE2 1 
ATOM   1248 N  N   . LEU A 1 180 ? -29.157 -9.729  -19.682 1.00 67.73  ? 443  LEU A N   1 
ATOM   1249 C  CA  . LEU A 1 180 ? -29.442 -8.809  -20.833 1.00 62.57  ? 443  LEU A CA  1 
ATOM   1250 C  C   . LEU A 1 180 ? -28.941 -7.397  -20.487 1.00 61.82  ? 443  LEU A C   1 
ATOM   1251 O  O   . LEU A 1 180 ? -28.459 -6.687  -21.386 1.00 65.37  ? 443  LEU A O   1 
ATOM   1252 C  CB  . LEU A 1 180 ? -30.942 -8.810  -21.162 1.00 62.77  ? 443  LEU A CB  1 
ATOM   1253 C  CG  . LEU A 1 180 ? -31.538 -10.125 -21.680 1.00 63.83  ? 443  LEU A CG  1 
ATOM   1254 C  CD1 . LEU A 1 180 ? -33.053 -10.026 -21.807 1.00 65.99  ? 443  LEU A CD1 1 
ATOM   1255 C  CD2 . LEU A 1 180 ? -30.937 -10.541 -23.013 1.00 65.12  ? 443  LEU A CD2 1 
ATOM   1256 N  N   . GLU A 1 181 ? -28.975 -7.041  -19.206 1.00 65.41  ? 444  GLU A N   1 
ATOM   1257 C  CA  . GLU A 1 181 ? -28.501 -5.742  -18.663 1.00 73.15  ? 444  GLU A CA  1 
ATOM   1258 C  C   . GLU A 1 181 ? -26.989 -5.804  -18.369 1.00 74.27  ? 444  GLU A C   1 
ATOM   1259 O  O   . GLU A 1 181 ? -26.443 -4.778  -17.920 1.00 70.33  ? 444  GLU A O   1 
ATOM   1260 C  CB  . GLU A 1 181 ? -29.343 -5.434  -17.421 1.00 79.35  ? 444  GLU A CB  1 
ATOM   1261 C  CG  . GLU A 1 181 ? -29.404 -3.973  -17.016 1.00 80.26  ? 444  GLU A CG  1 
ATOM   1262 C  CD  . GLU A 1 181 ? -30.013 -3.777  -15.634 1.00 83.39  ? 444  GLU A CD  1 
ATOM   1263 O  OE1 . GLU A 1 181 ? -29.526 -2.896  -14.884 1.00 80.58  ? 444  GLU A OE1 1 
ATOM   1264 O  OE2 . GLU A 1 181 ? -30.953 -4.532  -15.292 1.00 74.89  ? 444  GLU A OE2 1 
ATOM   1265 N  N   . GLY A 1 182 ? -26.328 -6.950  -18.603 1.00 74.02  ? 445  GLY A N   1 
ATOM   1266 C  CA  . GLY A 1 182 ? -24.860 -7.109  -18.487 1.00 64.52  ? 445  GLY A CA  1 
ATOM   1267 C  C   . GLY A 1 182 ? -24.377 -7.265  -17.046 1.00 59.40  ? 445  GLY A C   1 
ATOM   1268 O  O   . GLY A 1 182 ? -23.216 -6.935  -16.782 1.00 63.80  ? 445  GLY A O   1 
ATOM   1269 N  N   . LYS A 1 183 ? -25.228 -7.771  -16.149 1.00 55.81  ? 446  LYS A N   1 
ATOM   1270 C  CA  . LYS A 1 183 ? -24.988 -7.863  -14.683 1.00 56.06  ? 446  LYS A CA  1 
ATOM   1271 C  C   . LYS A 1 183 ? -25.386 -9.264  -14.188 1.00 48.23  ? 446  LYS A C   1 
ATOM   1272 O  O   . LYS A 1 183 ? -26.227 -9.898  -14.836 1.00 46.31  ? 446  LYS A O   1 
ATOM   1273 C  CB  . LYS A 1 183 ? -25.834 -6.827  -13.926 1.00 63.13  ? 446  LYS A CB  1 
ATOM   1274 C  CG  . LYS A 1 183 ? -25.585 -5.358  -14.263 1.00 64.61  ? 446  LYS A CG  1 
ATOM   1275 C  CD  . LYS A 1 183 ? -26.830 -4.492  -14.107 1.00 69.72  ? 446  LYS A CD  1 
ATOM   1276 C  CE  . LYS A 1 183 ? -26.548 -3.003  -14.162 1.00 73.49  ? 446  LYS A CE  1 
ATOM   1277 N  NZ  . LYS A 1 183 ? -26.805 -2.347  -12.856 1.00 74.27  ? 446  LYS A NZ  1 
ATOM   1278 N  N   . CYS A 1 184 ? -24.861 -9.701  -13.040 1.00 52.66  ? 447  CYS A N   1 
ATOM   1279 C  CA  . CYS A 1 184 ? -25.092 -11.053 -12.455 1.00 51.38  ? 447  CYS A CA  1 
ATOM   1280 C  C   . CYS A 1 184 ? -25.330 -10.921 -10.943 1.00 51.83  ? 447  CYS A C   1 
ATOM   1281 O  O   . CYS A 1 184 ? -24.560 -10.184 -10.289 1.00 56.06  ? 447  CYS A O   1 
ATOM   1282 C  CB  . CYS A 1 184 ? -23.888 -11.956 -12.749 1.00 51.88  ? 447  CYS A CB  1 
ATOM   1283 S  SG  . CYS A 1 184 ? -24.177 -13.717 -12.431 1.00 47.26  ? 447  CYS A SG  1 
ATOM   1284 N  N   . GLU A 1 185 ? -26.307 -11.643 -10.389 1.00 51.56  ? 448  GLU A N   1 
ATOM   1285 C  CA  . GLU A 1 185 ? -26.573 -11.618 -8.926  1.00 58.29  ? 448  GLU A CA  1 
ATOM   1286 C  C   . GLU A 1 185 ? -26.439 -13.007 -8.295  1.00 56.73  ? 448  GLU A C   1 
ATOM   1287 O  O   . GLU A 1 185 ? -26.059 -13.053 -7.106  1.00 59.48  ? 448  GLU A O   1 
ATOM   1288 C  CB  . GLU A 1 185 ? -27.947 -11.000 -8.635  1.00 65.52  ? 448  GLU A CB  1 
ATOM   1289 C  CG  . GLU A 1 185 ? -28.110 -10.547 -7.192  1.00 67.10  ? 448  GLU A CG  1 
ATOM   1290 C  CD  . GLU A 1 185 ? -29.480 -9.989  -6.847  1.00 70.36  ? 448  GLU A CD  1 
ATOM   1291 O  OE1 . GLU A 1 185 ? -29.529 -8.895  -6.247  1.00 75.91  ? 448  GLU A OE1 1 
ATOM   1292 O  OE2 . GLU A 1 185 ? -30.494 -10.646 -7.179  1.00 73.36  ? 448  GLU A OE2 1 
ATOM   1293 N  N   . THR A 1 186 ? -26.735 -14.101 -9.004  1.00 53.29  ? 449  THR A N   1 
ATOM   1294 C  CA  . THR A 1 186 ? -26.946 -15.416 -8.341  1.00 50.65  ? 449  THR A CA  1 
ATOM   1295 C  C   . THR A 1 186 ? -26.155 -16.565 -8.989  1.00 49.23  ? 449  THR A C   1 
ATOM   1296 O  O   . THR A 1 186 ? -26.257 -17.666 -8.440  1.00 49.48  ? 449  THR A O   1 
ATOM   1297 C  CB  . THR A 1 186 ? -28.442 -15.738 -8.296  1.00 57.54  ? 449  THR A CB  1 
ATOM   1298 O  OG1 . THR A 1 186 ? -28.886 -15.931 -9.637  1.00 58.88  ? 449  THR A OG1 1 
ATOM   1299 C  CG2 . THR A 1 186 ? -29.256 -14.640 -7.647  1.00 59.76  ? 449  THR A CG2 1 
ATOM   1300 N  N   . CYS A 1 187 ? -25.392 -16.342 -10.068 1.00 43.93  ? 450  CYS A N   1 
ATOM   1301 C  CA  . CYS A 1 187 ? -24.558 -17.388 -10.740 1.00 44.92  ? 450  CYS A CA  1 
ATOM   1302 C  C   . CYS A 1 187 ? -23.223 -17.563 -9.981  1.00 45.62  ? 450  CYS A C   1 
ATOM   1303 O  O   . CYS A 1 187 ? -22.180 -16.988 -10.396 1.00 45.35  ? 450  CYS A O   1 
ATOM   1304 C  CB  . CYS A 1 187 ? -24.373 -17.043 -12.212 1.00 45.16  ? 450  CYS A CB  1 
ATOM   1305 S  SG  . CYS A 1 187 ? -25.971 -16.801 -13.045 1.00 46.89  ? 450  CYS A SG  1 
ATOM   1306 N  N   . VAL A 1 188 ? -23.259 -18.352 -8.903  0.50 47.25  ? 451  VAL A N   1 
ATOM   1307 C  CA  . VAL A 1 188 ? -22.114 -18.589 -7.971  0.50 49.73  ? 451  VAL A CA  1 
ATOM   1308 C  C   . VAL A 1 188 ? -21.773 -20.084 -7.958  0.50 49.51  ? 451  VAL A C   1 
ATOM   1309 O  O   . VAL A 1 188 ? -22.695 -20.906 -7.797  0.50 46.33  ? 451  VAL A O   1 
ATOM   1310 C  CB  . VAL A 1 188 ? -22.442 -18.084 -6.553  0.50 51.85  ? 451  VAL A CB  1 
ATOM   1311 C  CG1 . VAL A 1 188 ? -21.466 -18.628 -5.520  0.50 53.12  ? 451  VAL A CG1 1 
ATOM   1312 C  CG2 . VAL A 1 188 ? -22.497 -16.566 -6.503  0.50 53.44  ? 451  VAL A CG2 1 
ATOM   1313 N  N   . TYR A 1 189 ? -20.487 -20.412 -8.097  1.00 49.99  ? 452  TYR A N   1 
ATOM   1314 C  CA  . TYR A 1 189 ? -19.998 -21.816 -8.116  1.00 55.88  ? 452  TYR A CA  1 
ATOM   1315 C  C   . TYR A 1 189 ? -19.833 -22.328 -6.683  1.00 61.17  ? 452  TYR A C   1 
ATOM   1316 O  O   . TYR A 1 189 ? -19.482 -21.543 -5.783  1.00 61.58  ? 452  TYR A O   1 
ATOM   1317 C  CB  . TYR A 1 189 ? -18.699 -21.917 -8.914  1.00 53.98  ? 452  TYR A CB  1 
ATOM   1318 C  CG  . TYR A 1 189 ? -18.903 -21.777 -10.399 1.00 55.13  ? 452  TYR A CG  1 
ATOM   1319 C  CD1 . TYR A 1 189 ? -19.633 -22.719 -11.108 1.00 61.40  ? 452  TYR A CD1 1 
ATOM   1320 C  CD2 . TYR A 1 189 ? -18.374 -20.706 -11.096 1.00 56.30  ? 452  TYR A CD2 1 
ATOM   1321 C  CE1 . TYR A 1 189 ? -19.838 -22.597 -12.473 1.00 61.70  ? 452  TYR A CE1 1 
ATOM   1322 C  CE2 . TYR A 1 189 ? -18.555 -20.575 -12.465 1.00 57.18  ? 452  TYR A CE2 1 
ATOM   1323 C  CZ  . TYR A 1 189 ? -19.291 -21.523 -13.152 1.00 57.45  ? 452  TYR A CZ  1 
ATOM   1324 O  OH  . TYR A 1 189 ? -19.481 -21.384 -14.493 1.00 66.09  ? 452  TYR A OH  1 
ATOM   1325 N  N   . ASN A 1 190 ? -20.164 -23.606 -6.472  0.50 65.63  ? 453  ASN A N   1 
ATOM   1326 C  CA  . ASN A 1 190 ? -20.065 -24.315 -5.167  0.50 68.92  ? 453  ASN A CA  1 
ATOM   1327 C  C   . ASN A 1 190 ? -19.115 -25.507 -5.336  0.50 71.45  ? 453  ASN A C   1 
ATOM   1328 O  O   . ASN A 1 190 ? -19.560 -26.548 -5.856  0.50 69.26  ? 453  ASN A O   1 
ATOM   1329 C  CB  . ASN A 1 190 ? -21.441 -24.747 -4.657  0.50 68.78  ? 453  ASN A CB  1 
ATOM   1330 C  CG  . ASN A 1 190 ? -22.485 -23.656 -4.774  0.50 70.46  ? 453  ASN A CG  1 
ATOM   1331 O  OD1 . ASN A 1 190 ? -22.732 -23.134 -5.859  0.50 73.24  ? 453  ASN A OD1 1 
ATOM   1332 N  ND2 . ASN A 1 190 ? -23.117 -23.314 -3.664  0.50 71.72  ? 453  ASN A ND2 1 
ATOM   1333 N  N   . MET A 1 191 ? -17.855 -25.342 -4.922  0.50 78.36  ? 454  MET A N   1 
ATOM   1334 C  CA  . MET A 1 191 ? -16.758 -26.331 -5.106  0.50 84.36  ? 454  MET A CA  1 
ATOM   1335 C  C   . MET A 1 191 ? -17.143 -27.651 -4.427  0.50 87.46  ? 454  MET A C   1 
ATOM   1336 O  O   . MET A 1 191 ? -17.939 -27.609 -3.464  0.50 86.28  ? 454  MET A O   1 
ATOM   1337 C  CB  . MET A 1 191 ? -15.449 -25.800 -4.511  0.50 86.33  ? 454  MET A CB  1 
ATOM   1338 C  CG  . MET A 1 191 ? -14.226 -26.611 -4.895  0.50 89.05  ? 454  MET A CG  1 
ATOM   1339 S  SD  . MET A 1 191 ? -12.677 -25.683 -4.696  0.50 93.08  ? 454  MET A SD  1 
ATOM   1340 C  CE  . MET A 1 191 ? -12.558 -24.890 -6.300  0.50 94.41  ? 454  MET A CE  1 
ATOM   1341 N  N   . MET A 1 192 ? -16.606 -28.770 -4.929  0.50 90.94  ? 455  MET A N   1 
ATOM   1342 C  CA  . MET A 1 192 ? -16.865 -30.149 -4.429  0.50 93.00  ? 455  MET A CA  1 
ATOM   1343 C  C   . MET A 1 192 ? -16.505 -31.166 -5.521  0.50 93.20  ? 455  MET A C   1 
ATOM   1344 O  O   . MET A 1 192 ? -15.360 -31.101 -6.014  0.50 92.78  ? 455  MET A O   1 
ATOM   1345 C  CB  . MET A 1 192 ? -18.336 -30.330 -4.040  0.50 93.64  ? 455  MET A CB  1 
ATOM   1346 C  CG  . MET A 1 192 ? -18.689 -29.737 -2.689  0.50 93.85  ? 455  MET A CG  1 
ATOM   1347 S  SD  . MET A 1 192 ? -20.478 -29.678 -2.399  0.50 95.30  ? 455  MET A SD  1 
ATOM   1348 C  CE  . MET A 1 192 ? -20.879 -31.424 -2.437  0.50 95.26  ? 455  MET A CE  1 
ATOM   1349 N  N   . ALA A 1 210 ? -12.603 -32.214 -10.304 0.50 63.07  ? 473  ALA A N   1 
ATOM   1350 C  CA  . ALA A 1 210 ? -13.249 -30.987 -9.780  0.50 62.31  ? 473  ALA A CA  1 
ATOM   1351 C  C   . ALA A 1 210 ? -14.603 -30.791 -10.471 0.50 63.75  ? 473  ALA A C   1 
ATOM   1352 O  O   . ALA A 1 210 ? -14.640 -30.795 -11.721 0.50 62.60  ? 473  ALA A O   1 
ATOM   1353 C  CB  . ALA A 1 210 ? -12.344 -29.796 -9.983  0.50 61.85  ? 473  ALA A CB  1 
ATOM   1354 N  N   . ILE A 1 211 ? -15.670 -30.638 -9.679  0.50 64.51  ? 474  ILE A N   1 
ATOM   1355 C  CA  . ILE A 1 211 ? -17.069 -30.444 -10.162 0.50 63.49  ? 474  ILE A CA  1 
ATOM   1356 C  C   . ILE A 1 211 ? -17.607 -29.125 -9.597  0.50 63.31  ? 474  ILE A C   1 
ATOM   1357 O  O   . ILE A 1 211 ? -17.718 -29.001 -8.362  0.50 58.93  ? 474  ILE A O   1 
ATOM   1358 C  CB  . ILE A 1 211 ? -17.964 -31.637 -9.775  0.50 64.54  ? 474  ILE A CB  1 
ATOM   1359 C  CG1 . ILE A 1 211 ? -17.324 -32.974 -10.162 0.50 66.23  ? 474  ILE A CG1 1 
ATOM   1360 C  CG2 . ILE A 1 211 ? -19.354 -31.479 -10.373 0.50 63.82  ? 474  ILE A CG2 1 
ATOM   1361 C  CD1 . ILE A 1 211 ? -16.117 -33.346 -9.327  0.50 66.31  ? 474  ILE A CD1 1 
ATOM   1362 N  N   . TRP A 1 212 ? -17.928 -28.185 -10.488 0.50 64.77  ? 475  TRP A N   1 
ATOM   1363 C  CA  . TRP A 1 212 ? -18.438 -26.830 -10.159 0.50 65.01  ? 475  TRP A CA  1 
ATOM   1364 C  C   . TRP A 1 212 ? -19.968 -26.853 -10.143 0.50 66.04  ? 475  TRP A C   1 
ATOM   1365 O  O   . TRP A 1 212 ? -20.566 -26.458 -11.159 0.50 71.82  ? 475  TRP A O   1 
ATOM   1366 C  CB  . TRP A 1 212 ? -17.911 -25.808 -11.173 0.50 64.77  ? 475  TRP A CB  1 
ATOM   1367 C  CG  . TRP A 1 212 ? -16.436 -25.885 -11.416 0.50 62.83  ? 475  TRP A CG  1 
ATOM   1368 C  CD1 . TRP A 1 212 ? -15.747 -26.903 -12.010 0.50 61.13  ? 475  TRP A CD1 1 
ATOM   1369 C  CD2 . TRP A 1 212 ? -15.461 -24.883 -11.079 0.50 62.65  ? 475  TRP A CD2 1 
ATOM   1370 N  NE1 . TRP A 1 212 ? -14.412 -26.606 -12.059 0.50 60.96  ? 475  TRP A NE1 1 
ATOM   1371 C  CE2 . TRP A 1 212 ? -14.206 -25.375 -11.493 0.50 62.03  ? 475  TRP A CE2 1 
ATOM   1372 C  CE3 . TRP A 1 212 ? -15.526 -23.624 -10.471 0.50 60.76  ? 475  TRP A CE3 1 
ATOM   1373 C  CZ2 . TRP A 1 212 ? -13.030 -24.647 -11.316 0.50 63.12  ? 475  TRP A CZ2 1 
ATOM   1374 C  CZ3 . TRP A 1 212 ? -14.364 -22.908 -10.298 0.50 62.22  ? 475  TRP A CZ3 1 
ATOM   1375 C  CH2 . TRP A 1 212 ? -13.133 -23.414 -10.715 0.50 62.70  ? 475  TRP A CH2 1 
ATOM   1376 N  N   . TYR A 1 213 ? -20.574 -27.301 -9.040  0.50 65.58  ? 476  TYR A N   1 
ATOM   1377 C  CA  . TYR A 1 213 ? -22.043 -27.270 -8.826  0.50 64.66  ? 476  TYR A CA  1 
ATOM   1378 C  C   . TYR A 1 213 ? -22.508 -25.809 -8.783  0.50 62.35  ? 476  TYR A C   1 
ATOM   1379 O  O   . TYR A 1 213 ? -21.826 -24.966 -8.168  0.50 59.46  ? 476  TYR A O   1 
ATOM   1380 C  CB  . TYR A 1 213 ? -22.431 -28.010 -7.543  0.50 68.60  ? 476  TYR A CB  1 
ATOM   1381 C  CG  . TYR A 1 213 ? -22.030 -29.463 -7.496  0.50 71.70  ? 476  TYR A CG  1 
ATOM   1382 C  CD1 . TYR A 1 213 ? -22.852 -30.452 -8.011  0.50 74.82  ? 476  TYR A CD1 1 
ATOM   1383 C  CD2 . TYR A 1 213 ? -20.833 -29.854 -6.919  0.50 74.15  ? 476  TYR A CD2 1 
ATOM   1384 C  CE1 . TYR A 1 213 ? -22.492 -31.790 -7.964  0.50 76.04  ? 476  TYR A CE1 1 
ATOM   1385 C  CE2 . TYR A 1 213 ? -20.458 -31.187 -6.861  0.50 75.02  ? 476  TYR A CE2 1 
ATOM   1386 C  CZ  . TYR A 1 213 ? -21.290 -32.160 -7.386  0.50 75.39  ? 476  TYR A CZ  1 
ATOM   1387 O  OH  . TYR A 1 213 ? -20.926 -33.475 -7.333  0.50 73.41  ? 476  TYR A OH  1 
ATOM   1388 N  N   . MET A 1 214 ? -23.630 -25.523 -9.446  0.50 59.31  ? 477  MET A N   1 
ATOM   1389 C  CA  . MET A 1 214 ? -24.344 -24.221 -9.392  0.50 58.04  ? 477  MET A CA  1 
ATOM   1390 C  C   . MET A 1 214 ? -25.819 -24.507 -9.121  0.50 54.70  ? 477  MET A C   1 
ATOM   1391 O  O   . MET A 1 214 ? -26.231 -25.660 -9.335  0.50 54.61  ? 477  MET A O   1 
ATOM   1392 C  CB  . MET A 1 214 ? -24.220 -23.459 -10.714 0.50 58.89  ? 477  MET A CB  1 
ATOM   1393 C  CG  . MET A 1 214 ? -23.208 -22.332 -10.695 0.50 59.09  ? 477  MET A CG  1 
ATOM   1394 S  SD  . MET A 1 214 ? -23.255 -21.410 -12.251 0.50 60.78  ? 477  MET A SD  1 
ATOM   1395 C  CE  . MET A 1 214 ? -22.089 -20.092 -11.916 0.50 58.43  ? 477  MET A CE  1 
ATOM   1396 N  N   . TRP A 1 215 ? -26.584 -23.509 -8.673  0.50 53.58  ? 478  TRP A N   1 
ATOM   1397 C  CA  . TRP A 1 215 ? -28.050 -23.655 -8.478  0.50 54.45  ? 478  TRP A CA  1 
ATOM   1398 C  C   . TRP A 1 215 ? -28.698 -23.867 -9.853  0.50 54.02  ? 478  TRP A C   1 
ATOM   1399 O  O   . TRP A 1 215 ? -28.104 -23.431 -10.861 0.50 49.65  ? 478  TRP A O   1 
ATOM   1400 C  CB  . TRP A 1 215 ? -28.637 -22.481 -7.676  0.50 53.88  ? 478  TRP A CB  1 
ATOM   1401 C  CG  . TRP A 1 215 ? -29.082 -21.279 -8.452  0.50 55.00  ? 478  TRP A CG  1 
ATOM   1402 C  CD1 . TRP A 1 215 ? -28.296 -20.299 -8.987  0.50 56.28  ? 478  TRP A CD1 1 
ATOM   1403 C  CD2 . TRP A 1 215 ? -30.441 -20.884 -8.715  0.50 55.26  ? 478  TRP A CD2 1 
ATOM   1404 N  NE1 . TRP A 1 215 ? -29.068 -19.343 -9.592  0.50 57.78  ? 478  TRP A NE1 1 
ATOM   1405 C  CE2 . TRP A 1 215 ? -30.388 -19.674 -9.440  0.50 56.97  ? 478  TRP A CE2 1 
ATOM   1406 C  CE3 . TRP A 1 215 ? -31.690 -21.443 -8.424  0.50 54.00  ? 478  TRP A CE3 1 
ATOM   1407 C  CZ2 . TRP A 1 215 ? -31.537 -19.015 -9.875  0.50 56.50  ? 478  TRP A CZ2 1 
ATOM   1408 C  CZ3 . TRP A 1 215 ? -32.824 -20.796 -8.862  0.50 55.79  ? 478  TRP A CZ3 1 
ATOM   1409 C  CH2 . TRP A 1 215 ? -32.747 -19.599 -9.575  0.50 56.08  ? 478  TRP A CH2 1 
ATOM   1410 N  N   . LEU A 1 216 ? -29.833 -24.570 -9.887  1.00 55.26  ? 479  LEU A N   1 
ATOM   1411 C  CA  . LEU A 1 216 ? -30.473 -25.051 -11.142 1.00 56.03  ? 479  LEU A CA  1 
ATOM   1412 C  C   . LEU A 1 216 ? -30.716 -23.903 -12.131 1.00 59.49  ? 479  LEU A C   1 
ATOM   1413 O  O   . LEU A 1 216 ? -30.470 -24.117 -13.326 1.00 53.95  ? 479  LEU A O   1 
ATOM   1414 C  CB  . LEU A 1 216 ? -31.772 -25.779 -10.787 1.00 61.25  ? 479  LEU A CB  1 
ATOM   1415 C  CG  . LEU A 1 216 ? -32.242 -26.794 -11.827 1.00 61.04  ? 479  LEU A CG  1 
ATOM   1416 C  CD1 . LEU A 1 216 ? -31.155 -27.822 -12.107 1.00 57.03  ? 479  LEU A CD1 1 
ATOM   1417 C  CD2 . LEU A 1 216 ? -33.523 -27.476 -11.375 1.00 61.07  ? 479  LEU A CD2 1 
ATOM   1418 N  N   . GLY A 1 217 ? -31.105 -22.727 -11.636 1.00 53.91  ? 480  GLY A N   1 
ATOM   1419 C  CA  . GLY A 1 217 ? -31.351 -21.513 -12.431 1.00 54.96  ? 480  GLY A CA  1 
ATOM   1420 C  C   . GLY A 1 217 ? -30.139 -21.067 -13.226 1.00 55.16  ? 480  GLY A C   1 
ATOM   1421 O  O   . GLY A 1 217 ? -30.311 -20.769 -14.424 1.00 45.22  ? 480  GLY A O   1 
ATOM   1422 N  N   . ALA A 1 218 ? -28.955 -21.014 -12.604 1.00 51.94  ? 481  ALA A N   1 
ATOM   1423 C  CA  . ALA A 1 218 ? -27.687 -20.652 -13.287 1.00 46.90  ? 481  ALA A CA  1 
ATOM   1424 C  C   . ALA A 1 218 ? -27.369 -21.709 -14.348 1.00 46.09  ? 481  ALA A C   1 
ATOM   1425 O  O   . ALA A 1 218 ? -26.888 -21.324 -15.422 1.00 42.98  ? 481  ALA A O   1 
ATOM   1426 C  CB  . ALA A 1 218 ? -26.571 -20.531 -12.291 1.00 46.20  ? 481  ALA A CB  1 
ATOM   1427 N  N   . ARG A 1 219 ? -27.656 -22.982 -14.048 1.00 47.04  ? 482  ARG A N   1 
ATOM   1428 C  CA  . ARG A 1 219 ? -27.431 -24.143 -14.954 1.00 50.18  ? 482  ARG A CA  1 
ATOM   1429 C  C   . ARG A 1 219 ? -28.326 -23.991 -16.173 1.00 49.29  ? 482  ARG A C   1 
ATOM   1430 O  O   . ARG A 1 219 ? -27.864 -24.301 -17.293 1.00 37.73  ? 482  ARG A O   1 
ATOM   1431 C  CB  . ARG A 1 219 ? -27.755 -25.480 -14.289 1.00 49.01  ? 482  ARG A CB  1 
ATOM   1432 C  CG  . ARG A 1 219 ? -26.527 -26.336 -14.059 1.00 63.85  ? 482  ARG A CG  1 
ATOM   1433 C  CD  . ARG A 1 219 ? -25.570 -25.556 -13.184 1.00 66.38  ? 482  ARG A CD  1 
ATOM   1434 N  NE  . ARG A 1 219 ? -24.205 -26.056 -13.030 1.00 70.69  ? 482  ARG A NE  1 
ATOM   1435 C  CZ  . ARG A 1 219 ? -23.156 -25.679 -13.753 1.00 67.79  ? 482  ARG A CZ  1 
ATOM   1436 N  NH1 . ARG A 1 219 ? -23.286 -24.844 -14.772 1.00 63.42  ? 482  ARG A NH1 1 
ATOM   1437 N  NH2 . ARG A 1 219 ? -21.966 -26.160 -13.452 1.00 79.56  ? 482  ARG A NH2 1 
ATOM   1438 N  N   . PHE A 1 220 ? -29.554 -23.522 -15.946 1.00 46.59  ? 483  PHE A N   1 
ATOM   1439 C  CA  . PHE A 1 220 ? -30.529 -23.318 -17.034 1.00 43.23  ? 483  PHE A CA  1 
ATOM   1440 C  C   . PHE A 1 220 ? -29.982 -22.258 -17.980 1.00 41.26  ? 483  PHE A C   1 
ATOM   1441 O  O   . PHE A 1 220 ? -29.970 -22.493 -19.201 1.00 44.67  ? 483  PHE A O   1 
ATOM   1442 C  CB  . PHE A 1 220 ? -31.914 -22.886 -16.547 1.00 43.36  ? 483  PHE A CB  1 
ATOM   1443 C  CG  . PHE A 1 220 ? -32.770 -22.571 -17.739 1.00 37.61  ? 483  PHE A CG  1 
ATOM   1444 C  CD1 . PHE A 1 220 ? -33.150 -23.583 -18.596 1.00 41.95  ? 483  PHE A CD1 1 
ATOM   1445 C  CD2 . PHE A 1 220 ? -33.023 -21.265 -18.100 1.00 40.85  ? 483  PHE A CD2 1 
ATOM   1446 C  CE1 . PHE A 1 220 ? -33.867 -23.300 -19.748 1.00 45.82  ? 483  PHE A CE1 1 
ATOM   1447 C  CE2 . PHE A 1 220 ? -33.723 -20.975 -19.263 1.00 41.95  ? 483  PHE A CE2 1 
ATOM   1448 C  CZ  . PHE A 1 220 ? -34.148 -21.996 -20.077 1.00 42.69  ? 483  PHE A CZ  1 
ATOM   1449 N  N   . LEU A 1 221 ? -29.591 -21.111 -17.434 1.00 39.98  ? 484  LEU A N   1 
ATOM   1450 C  CA  . LEU A 1 221 ? -29.106 -19.967 -18.243 1.00 43.44  ? 484  LEU A CA  1 
ATOM   1451 C  C   . LEU A 1 221 ? -27.862 -20.385 -19.040 1.00 44.13  ? 484  LEU A C   1 
ATOM   1452 O  O   . LEU A 1 221 ? -27.703 -19.917 -20.208 1.00 37.16  ? 484  LEU A O   1 
ATOM   1453 C  CB  . LEU A 1 221 ? -28.830 -18.781 -17.323 1.00 45.24  ? 484  LEU A CB  1 
ATOM   1454 C  CG  . LEU A 1 221 ? -30.079 -18.079 -16.783 1.00 47.97  ? 484  LEU A CG  1 
ATOM   1455 C  CD1 . LEU A 1 221 ? -29.687 -16.887 -15.926 1.00 53.77  ? 484  LEU A CD1 1 
ATOM   1456 C  CD2 . LEU A 1 221 ? -30.993 -17.625 -17.915 1.00 49.51  ? 484  LEU A CD2 1 
ATOM   1457 N  N   . GLU A 1 222 ? -26.992 -21.219 -18.453 1.00 40.87  ? 485  GLU A N   1 
ATOM   1458 C  CA  . GLU A 1 222 ? -25.824 -21.742 -19.208 1.00 38.06  ? 485  GLU A CA  1 
ATOM   1459 C  C   . GLU A 1 222 ? -26.365 -22.622 -20.357 1.00 35.98  ? 485  GLU A C   1 
ATOM   1460 O  O   . GLU A 1 222 ? -25.912 -22.424 -21.484 1.00 36.67  ? 485  GLU A O   1 
ATOM   1461 C  CB  . GLU A 1 222 ? -24.835 -22.417 -18.246 1.00 41.53  ? 485  GLU A CB  1 
ATOM   1462 C  CG  . GLU A 1 222 ? -23.672 -23.076 -18.953 1.00 44.50  ? 485  GLU A CG  1 
ATOM   1463 C  CD  . GLU A 1 222 ? -22.809 -23.965 -18.073 1.00 42.74  ? 485  GLU A CD  1 
ATOM   1464 O  OE1 . GLU A 1 222 ? -21.612 -23.665 -17.953 1.00 41.85  ? 485  GLU A OE1 1 
ATOM   1465 O  OE2 . GLU A 1 222 ? -23.328 -24.962 -17.554 1.00 43.81  ? 485  GLU A OE2 1 
ATOM   1466 N  N   . PHE A 1 223 ? -27.337 -23.509 -20.103 1.00 35.93  ? 486  PHE A N   1 
ATOM   1467 C  CA  . PHE A 1 223 ? -27.890 -24.476 -21.093 1.00 40.07  ? 486  PHE A CA  1 
ATOM   1468 C  C   . PHE A 1 223 ? -28.574 -23.714 -22.234 1.00 42.36  ? 486  PHE A C   1 
ATOM   1469 O  O   . PHE A 1 223 ? -28.364 -24.049 -23.413 1.00 37.75  ? 486  PHE A O   1 
ATOM   1470 C  CB  . PHE A 1 223 ? -28.809 -25.479 -20.403 1.00 41.90  ? 486  PHE A CB  1 
ATOM   1471 C  CG  . PHE A 1 223 ? -29.508 -26.437 -21.332 1.00 40.11  ? 486  PHE A CG  1 
ATOM   1472 C  CD1 . PHE A 1 223 ? -28.818 -27.466 -21.940 1.00 39.47  ? 486  PHE A CD1 1 
ATOM   1473 C  CD2 . PHE A 1 223 ? -30.857 -26.283 -21.616 1.00 40.20  ? 486  PHE A CD2 1 
ATOM   1474 C  CE1 . PHE A 1 223 ? -29.460 -28.325 -22.817 1.00 44.81  ? 486  PHE A CE1 1 
ATOM   1475 C  CE2 . PHE A 1 223 ? -31.498 -27.147 -22.480 1.00 40.69  ? 486  PHE A CE2 1 
ATOM   1476 C  CZ  . PHE A 1 223 ? -30.805 -28.177 -23.070 1.00 44.93  ? 486  PHE A CZ  1 
ATOM   1477 N  N   . GLU A 1 224 ? -29.347 -22.687 -21.885 0.50 42.40  ? 487  GLU A N   1 
ATOM   1478 C  CA  . GLU A 1 224 ? -30.095 -21.840 -22.846 0.50 42.12  ? 487  GLU A CA  1 
ATOM   1479 C  C   . GLU A 1 224 ? -29.120 -21.213 -23.852 0.50 42.42  ? 487  GLU A C   1 
ATOM   1480 O  O   . GLU A 1 224 ? -29.428 -21.219 -25.066 0.50 40.11  ? 487  GLU A O   1 
ATOM   1481 C  CB  . GLU A 1 224 ? -30.867 -20.772 -22.074 0.50 43.19  ? 487  GLU A CB  1 
ATOM   1482 C  CG  . GLU A 1 224 ? -31.727 -19.889 -22.951 0.50 43.17  ? 487  GLU A CG  1 
ATOM   1483 C  CD  . GLU A 1 224 ? -32.804 -19.153 -22.178 0.50 43.34  ? 487  GLU A CD  1 
ATOM   1484 O  OE1 . GLU A 1 224 ? -33.994 -19.394 -22.462 0.50 39.48  ? 487  GLU A OE1 1 
ATOM   1485 O  OE2 . GLU A 1 224 ? -32.445 -18.349 -21.293 0.50 42.85  ? 487  GLU A OE2 1 
ATOM   1486 N  N   . ALA A 1 225 ? -27.976 -20.717 -23.371 1.00 38.77  ? 488  ALA A N   1 
ATOM   1487 C  CA  . ALA A 1 225 ? -27.020 -19.961 -24.198 1.00 38.41  ? 488  ALA A CA  1 
ATOM   1488 C  C   . ALA A 1 225 ? -26.071 -20.890 -24.964 1.00 35.11  ? 488  ALA A C   1 
ATOM   1489 O  O   . ALA A 1 225 ? -25.704 -20.501 -26.117 1.00 32.90  ? 488  ALA A O   1 
ATOM   1490 C  CB  . ALA A 1 225 ? -26.264 -18.989 -23.328 1.00 39.87  ? 488  ALA A CB  1 
ATOM   1491 N  N   . LEU A 1 226 ? -25.637 -22.011 -24.369 1.00 34.64  ? 489  LEU A N   1 
ATOM   1492 C  CA  . LEU A 1 226 ? -24.456 -22.782 -24.876 1.00 31.79  ? 489  LEU A CA  1 
ATOM   1493 C  C   . LEU A 1 226 ? -24.767 -24.272 -25.038 1.00 31.57  ? 489  LEU A C   1 
ATOM   1494 O  O   . LEU A 1 226 ? -23.908 -24.996 -25.590 1.00 32.53  ? 489  LEU A O   1 
ATOM   1495 C  CB  . LEU A 1 226 ? -23.270 -22.549 -23.927 1.00 30.21  ? 489  LEU A CB  1 
ATOM   1496 C  CG  . LEU A 1 226 ? -22.714 -21.119 -23.886 1.00 34.34  ? 489  LEU A CG  1 
ATOM   1497 C  CD1 . LEU A 1 226 ? -21.469 -21.017 -23.003 1.00 37.44  ? 489  LEU A CD1 1 
ATOM   1498 C  CD2 . LEU A 1 226 ? -22.353 -20.624 -25.276 1.00 38.48  ? 489  LEU A CD2 1 
ATOM   1499 N  N   . GLY A 1 227 ? -25.980 -24.734 -24.676 1.00 29.09  ? 490  GLY A N   1 
ATOM   1500 C  CA  . GLY A 1 227 ? -26.367 -26.143 -24.787 1.00 29.87  ? 490  GLY A CA  1 
ATOM   1501 C  C   . GLY A 1 227 ? -26.366 -26.648 -26.207 1.00 26.58  ? 490  GLY A C   1 
ATOM   1502 O  O   . GLY A 1 227 ? -26.173 -27.875 -26.419 1.00 27.54  ? 490  GLY A O   1 
ATOM   1503 N  N   . PHE A 1 228 ? -26.549 -25.755 -27.174 1.00 29.52  ? 491  PHE A N   1 
ATOM   1504 C  CA  . PHE A 1 228 ? -26.564 -26.118 -28.614 1.00 28.97  ? 491  PHE A CA  1 
ATOM   1505 C  C   . PHE A 1 228 ? -25.276 -26.853 -28.993 1.00 25.92  ? 491  PHE A C   1 
ATOM   1506 O  O   . PHE A 1 228 ? -25.339 -27.723 -29.882 1.00 25.42  ? 491  PHE A O   1 
ATOM   1507 C  CB  . PHE A 1 228 ? -26.771 -24.912 -29.534 1.00 28.67  ? 491  PHE A CB  1 
ATOM   1508 C  CG  . PHE A 1 228 ? -25.627 -23.947 -29.646 1.00 26.18  ? 491  PHE A CG  1 
ATOM   1509 C  CD1 . PHE A 1 228 ? -25.464 -22.930 -28.718 1.00 31.04  ? 491  PHE A CD1 1 
ATOM   1510 C  CD2 . PHE A 1 228 ? -24.683 -24.077 -30.649 1.00 28.78  ? 491  PHE A CD2 1 
ATOM   1511 C  CE1 . PHE A 1 228 ? -24.386 -22.061 -28.790 1.00 31.24  ? 491  PHE A CE1 1 
ATOM   1512 C  CE2 . PHE A 1 228 ? -23.614 -23.188 -30.731 1.00 27.88  ? 491  PHE A CE2 1 
ATOM   1513 C  CZ  . PHE A 1 228 ? -23.453 -22.196 -29.792 1.00 29.38  ? 491  PHE A CZ  1 
ATOM   1514 N  N   . LEU A 1 229 ? -24.133 -26.520 -28.380 1.00 28.21  ? 492  LEU A N   1 
ATOM   1515 C  CA  . LEU A 1 229 ? -22.864 -27.206 -28.761 1.00 27.71  ? 492  LEU A CA  1 
ATOM   1516 C  C   . LEU A 1 229 ? -23.004 -28.719 -28.594 1.00 25.01  ? 492  LEU A C   1 
ATOM   1517 O  O   . LEU A 1 229 ? -22.619 -29.477 -29.510 1.00 29.65  ? 492  LEU A O   1 
ATOM   1518 C  CB  . LEU A 1 229 ? -21.714 -26.647 -27.915 1.00 29.60  ? 492  LEU A CB  1 
ATOM   1519 C  CG  . LEU A 1 229 ? -21.335 -25.208 -28.247 1.00 30.99  ? 492  LEU A CG  1 
ATOM   1520 C  CD1 . LEU A 1 229 ? -20.364 -24.677 -27.226 1.00 35.30  ? 492  LEU A CD1 1 
ATOM   1521 C  CD2 . LEU A 1 229 ? -20.749 -25.114 -29.645 1.00 30.92  ? 492  LEU A CD2 1 
ATOM   1522 N  N   . ASN A 1 230 ? -23.617 -29.154 -27.500 1.00 28.15  ? 493  ASN A N   1 
ATOM   1523 C  CA  . ASN A 1 230 ? -23.846 -30.595 -27.235 1.00 27.57  ? 493  ASN A CA  1 
ATOM   1524 C  C   . ASN A 1 230 ? -25.153 -31.093 -27.870 1.00 28.27  ? 493  ASN A C   1 
ATOM   1525 O  O   . ASN A 1 230 ? -25.133 -32.162 -28.526 1.00 25.89  ? 493  ASN A O   1 
ATOM   1526 C  CB  . ASN A 1 230 ? -23.898 -30.863 -25.743 1.00 32.13  ? 493  ASN A CB  1 
ATOM   1527 C  CG  . ASN A 1 230 ? -23.954 -32.347 -25.476 1.00 36.47  ? 493  ASN A CG  1 
ATOM   1528 O  OD1 . ASN A 1 230 ? -24.956 -32.857 -24.972 1.00 39.67  ? 493  ASN A OD1 1 
ATOM   1529 N  ND2 . ASN A 1 230 ? -22.895 -33.043 -25.843 1.00 34.74  ? 493  ASN A ND2 1 
ATOM   1530 N  N   . GLU A 1 231 ? -26.251 -30.360 -27.700 1.00 29.25  ? 494  GLU A N   1 
ATOM   1531 C  CA  . GLU A 1 231 ? -27.585 -30.833 -28.181 1.00 30.56  ? 494  GLU A CA  1 
ATOM   1532 C  C   . GLU A 1 231 ? -27.574 -31.038 -29.702 1.00 29.23  ? 494  GLU A C   1 
ATOM   1533 O  O   . GLU A 1 231 ? -28.286 -31.938 -30.169 1.00 28.78  ? 494  GLU A O   1 
ATOM   1534 C  CB  . GLU A 1 231 ? -28.670 -29.832 -27.783 1.00 34.21  ? 494  GLU A CB  1 
ATOM   1535 C  CG  . GLU A 1 231 ? -28.926 -29.758 -26.293 1.00 36.16  ? 494  GLU A CG  1 
ATOM   1536 C  CD  . GLU A 1 231 ? -29.478 -31.037 -25.685 1.00 44.49  ? 494  GLU A CD  1 
ATOM   1537 O  OE1 . GLU A 1 231 ? -30.327 -31.694 -26.316 1.00 43.28  ? 494  GLU A OE1 1 
ATOM   1538 O  OE2 . GLU A 1 231 ? -29.028 -31.383 -24.599 1.00 50.52  ? 494  GLU A OE2 1 
ATOM   1539 N  N   . ASP A 1 232 ? -26.863 -30.192 -30.459 1.00 26.99  ? 495  ASP A N   1 
ATOM   1540 C  CA  . ASP A 1 232 ? -26.806 -30.242 -31.945 1.00 26.08  ? 495  ASP A CA  1 
ATOM   1541 C  C   . ASP A 1 232 ? -25.446 -30.770 -32.445 1.00 29.69  ? 495  ASP A C   1 
ATOM   1542 O  O   . ASP A 1 232 ? -25.183 -30.715 -33.681 1.00 28.01  ? 495  ASP A O   1 
ATOM   1543 C  CB  . ASP A 1 232 ? -27.112 -28.864 -32.529 1.00 28.10  ? 495  ASP A CB  1 
ATOM   1544 C  CG  . ASP A 1 232 ? -28.450 -28.295 -32.067 1.00 28.64  ? 495  ASP A CG  1 
ATOM   1545 O  OD1 . ASP A 1 232 ? -29.279 -29.097 -31.651 1.00 34.39  ? 495  ASP A OD1 1 
ATOM   1546 O  OD2 . ASP A 1 232 ? -28.584 -27.063 -32.054 1.00 30.10  ? 495  ASP A OD2 1 
ATOM   1547 N  N   . HIS A 1 233 ? -24.661 -31.392 -31.551 1.00 28.93  ? 496  HIS A N   1 
ATOM   1548 C  CA  . HIS A 1 233 ? -23.530 -32.281 -31.934 1.00 29.12  ? 496  HIS A CA  1 
ATOM   1549 C  C   . HIS A 1 233 ? -22.459 -31.536 -32.742 1.00 23.59  ? 496  HIS A C   1 
ATOM   1550 O  O   . HIS A 1 233 ? -21.998 -32.082 -33.769 1.00 26.64  ? 496  HIS A O   1 
ATOM   1551 C  CB  . HIS A 1 233 ? -24.040 -33.488 -32.734 1.00 31.84  ? 496  HIS A CB  1 
ATOM   1552 C  CG  . HIS A 1 233 ? -25.181 -34.193 -32.099 1.00 38.68  ? 496  HIS A CG  1 
ATOM   1553 N  ND1 . HIS A 1 233 ? -25.045 -34.895 -30.924 1.00 44.77  ? 496  HIS A ND1 1 
ATOM   1554 C  CD2 . HIS A 1 233 ? -26.492 -34.257 -32.453 1.00 44.12  ? 496  HIS A CD2 1 
ATOM   1555 C  CE1 . HIS A 1 233 ? -26.227 -35.390 -30.581 1.00 48.08  ? 496  HIS A CE1 1 
ATOM   1556 N  NE2 . HIS A 1 233 ? -27.125 -35.020 -31.521 1.00 44.60  ? 496  HIS A NE2 1 
ATOM   1557 N  N   . TRP A 1 234 ? -22.043 -30.369 -32.289 1.00 23.58  ? 497  TRP A N   1 
ATOM   1558 C  CA  . TRP A 1 234 ? -20.994 -29.538 -32.943 1.00 25.11  ? 497  TRP A CA  1 
ATOM   1559 C  C   . TRP A 1 234 ? -19.656 -30.306 -32.962 1.00 25.68  ? 497  TRP A C   1 
ATOM   1560 O  O   . TRP A 1 234 ? -18.890 -30.147 -33.958 1.00 23.95  ? 497  TRP A O   1 
ATOM   1561 C  CB  . TRP A 1 234 ? -20.857 -28.187 -32.260 1.00 25.51  ? 497  TRP A CB  1 
ATOM   1562 C  CG  . TRP A 1 234 ? -21.886 -27.197 -32.730 1.00 28.93  ? 497  TRP A CG  1 
ATOM   1563 C  CD1 . TRP A 1 234 ? -23.242 -27.396 -32.796 1.00 28.43  ? 497  TRP A CD1 1 
ATOM   1564 C  CD2 . TRP A 1 234 ? -21.641 -25.901 -33.313 1.00 26.56  ? 497  TRP A CD2 1 
ATOM   1565 N  NE1 . TRP A 1 234 ? -23.861 -26.283 -33.327 1.00 28.11  ? 497  TRP A NE1 1 
ATOM   1566 C  CE2 . TRP A 1 234 ? -22.907 -25.363 -33.667 1.00 27.77  ? 497  TRP A CE2 1 
ATOM   1567 C  CE3 . TRP A 1 234 ? -20.495 -25.124 -33.542 1.00 26.67  ? 497  TRP A CE3 1 
ATOM   1568 C  CZ2 . TRP A 1 234 ? -23.040 -24.096 -34.226 1.00 29.19  ? 497  TRP A CZ2 1 
ATOM   1569 C  CZ3 . TRP A 1 234 ? -20.631 -23.877 -34.120 1.00 29.88  ? 497  TRP A CZ3 1 
ATOM   1570 C  CH2 . TRP A 1 234 ? -21.898 -23.368 -34.442 1.00 28.66  ? 497  TRP A CH2 1 
ATOM   1571 N  N   . PHE A 1 235 ? -19.440 -31.189 -31.981 1.00 24.85  ? 498  PHE A N   1 
ATOM   1572 C  CA  . PHE A 1 235 ? -18.187 -31.977 -31.871 1.00 23.76  ? 498  PHE A CA  1 
ATOM   1573 C  C   . PHE A 1 235 ? -18.322 -33.433 -32.333 1.00 26.90  ? 498  PHE A C   1 
ATOM   1574 O  O   . PHE A 1 235 ? -17.423 -34.257 -32.027 1.00 23.01  ? 498  PHE A O   1 
ATOM   1575 C  CB  . PHE A 1 235 ? -17.576 -31.771 -30.478 1.00 22.62  ? 498  PHE A CB  1 
ATOM   1576 C  CG  . PHE A 1 235 ? -17.218 -30.331 -30.228 1.00 22.45  ? 498  PHE A CG  1 
ATOM   1577 C  CD1 . PHE A 1 235 ? -16.154 -29.746 -30.911 1.00 24.54  ? 498  PHE A CD1 1 
ATOM   1578 C  CD2 . PHE A 1 235 ? -18.049 -29.510 -29.475 1.00 25.06  ? 498  PHE A CD2 1 
ATOM   1579 C  CE1 . PHE A 1 235 ? -15.874 -28.400 -30.770 1.00 24.95  ? 498  PHE A CE1 1 
ATOM   1580 C  CE2 . PHE A 1 235 ? -17.770 -28.149 -29.353 1.00 26.15  ? 498  PHE A CE2 1 
ATOM   1581 C  CZ  . PHE A 1 235 ? -16.687 -27.599 -30.000 1.00 26.85  ? 498  PHE A CZ  1 
ATOM   1582 N  N   . SER A 1 236 ? -19.392 -33.766 -33.064 0.50 24.82  ? 499  SER A N   1 
ATOM   1583 C  CA  . SER A 1 236 ? -19.498 -35.032 -33.834 0.50 25.16  ? 499  SER A CA  1 
ATOM   1584 C  C   . SER A 1 236 ? -18.259 -35.162 -34.726 0.50 24.26  ? 499  SER A C   1 
ATOM   1585 O  O   . SER A 1 236 ? -17.714 -34.113 -35.108 0.50 25.27  ? 499  SER A O   1 
ATOM   1586 C  CB  . SER A 1 236 ? -20.751 -35.037 -34.669 0.50 25.09  ? 499  SER A CB  1 
ATOM   1587 O  OG  . SER A 1 236 ? -20.728 -33.954 -35.590 0.50 25.13  ? 499  SER A OG  1 
ATOM   1588 N  N   . ARG A 1 237 ? -17.842 -36.381 -35.058 1.00 23.74  ? 500  ARG A N   1 
ATOM   1589 C  CA  . ARG A 1 237 ? -16.749 -36.584 -36.034 1.00 24.36  ? 500  ARG A CA  1 
ATOM   1590 C  C   . ARG A 1 237 ? -17.142 -36.049 -37.430 1.00 28.56  ? 500  ARG A C   1 
ATOM   1591 O  O   . ARG A 1 237 ? -16.326 -35.377 -38.056 1.00 25.20  ? 500  ARG A O   1 
ATOM   1592 C  CB  . ARG A 1 237 ? -16.318 -38.045 -36.071 1.00 25.33  ? 500  ARG A CB  1 
ATOM   1593 C  CG  . ARG A 1 237 ? -14.975 -38.217 -36.754 1.00 24.23  ? 500  ARG A CG  1 
ATOM   1594 C  CD  . ARG A 1 237 ? -14.251 -39.467 -36.338 1.00 23.94  ? 500  ARG A CD  1 
ATOM   1595 N  NE  . ARG A 1 237 ? -12.877 -39.405 -36.787 1.00 21.81  ? 500  ARG A NE  1 
ATOM   1596 C  CZ  . ARG A 1 237 ? -11.871 -38.771 -36.174 1.00 23.06  ? 500  ARG A CZ  1 
ATOM   1597 N  NH1 . ARG A 1 237 ? -12.036 -38.109 -35.047 1.00 21.07  ? 500  ARG A NH1 1 
ATOM   1598 N  NH2 . ARG A 1 237 ? -10.680 -38.843 -36.718 1.00 24.55  ? 500  ARG A NH2 1 
ATOM   1599 N  N   . GLU A 1 238 ? -18.399 -36.220 -37.854 1.00 28.03  ? 501  GLU A N   1 
ATOM   1600 C  CA  . GLU A 1 238 ? -18.895 -35.701 -39.158 1.00 29.63  ? 501  GLU A CA  1 
ATOM   1601 C  C   . GLU A 1 238 ? -18.685 -34.190 -39.236 1.00 26.48  ? 501  GLU A C   1 
ATOM   1602 O  O   . GLU A 1 238 ? -18.185 -33.691 -40.234 1.00 30.93  ? 501  GLU A O   1 
ATOM   1603 C  CB  . GLU A 1 238 ? -20.379 -36.069 -39.345 1.00 35.41  ? 501  GLU A CB  1 
ATOM   1604 C  CG  . GLU A 1 238 ? -20.917 -35.709 -40.712 1.00 41.57  ? 501  GLU A CG  1 
ATOM   1605 C  CD  . GLU A 1 238 ? -22.371 -36.096 -40.959 1.00 53.12  ? 501  GLU A CD  1 
ATOM   1606 O  OE1 . GLU A 1 238 ? -22.934 -35.577 -41.918 1.00 62.52  ? 501  GLU A OE1 1 
ATOM   1607 O  OE2 . GLU A 1 238 ? -22.940 -36.920 -40.202 1.00 58.93  ? 501  GLU A OE2 1 
ATOM   1608 N  N   . ASN A 1 239 ? -19.024 -33.451 -38.173 0.50 25.80  ? 502  ASN A N   1 
ATOM   1609 C  CA  . ASN A 1 239 ? -19.012 -31.963 -38.191 0.50 26.06  ? 502  ASN A CA  1 
ATOM   1610 C  C   . ASN A 1 239 ? -17.655 -31.351 -37.817 0.50 25.84  ? 502  ASN A C   1 
ATOM   1611 O  O   . ASN A 1 239 ? -17.392 -30.228 -38.290 0.50 22.55  ? 502  ASN A O   1 
ATOM   1612 C  CB  . ASN A 1 239 ? -20.033 -31.317 -37.257 0.50 25.97  ? 502  ASN A CB  1 
ATOM   1613 C  CG  . ASN A 1 239 ? -20.092 -29.826 -37.504 0.50 26.99  ? 502  ASN A CG  1 
ATOM   1614 O  OD1 . ASN A 1 239 ? -20.421 -29.406 -38.620 0.50 26.57  ? 502  ASN A OD1 1 
ATOM   1615 N  ND2 . ASN A 1 239 ? -19.748 -29.019 -36.502 0.50 24.94  ? 502  ASN A ND2 1 
ATOM   1616 N  N   . SER A 1 240 ? -16.876 -31.972 -36.920 1.00 25.10  ? 503  SER A N   1 
ATOM   1617 C  CA  . SER A 1 240 ? -15.606 -31.352 -36.415 1.00 24.87  ? 503  SER A CA  1 
ATOM   1618 C  C   . SER A 1 240 ? -14.325 -32.029 -36.945 1.00 22.79  ? 503  SER A C   1 
ATOM   1619 O  O   . SER A 1 240 ? -13.264 -31.443 -36.709 1.00 23.85  ? 503  SER A O   1 
ATOM   1620 C  CB  . SER A 1 240 ? -15.616 -31.385 -34.898 1.00 24.92  ? 503  SER A CB  1 
ATOM   1621 O  OG  . SER A 1 240 ? -15.473 -32.754 -34.462 1.00 22.54  ? 503  SER A OG  1 
ATOM   1622 N  N   . LEU A 1 241 ? -14.416 -33.209 -37.556 1.00 22.95  ? 504  LEU A N   1 
ATOM   1623 C  CA  . LEU A 1 241 ? -13.355 -34.062 -38.156 1.00 25.59  ? 504  LEU A CA  1 
ATOM   1624 C  C   . LEU A 1 241 ? -12.426 -34.686 -37.093 1.00 22.93  ? 504  LEU A C   1 
ATOM   1625 O  O   . LEU A 1 241 ? -12.072 -35.855 -37.271 1.00 23.55  ? 504  LEU A O   1 
ATOM   1626 C  CB  . LEU A 1 241 ? -12.553 -33.287 -39.204 1.00 27.11  ? 504  LEU A CB  1 
ATOM   1627 C  CG  . LEU A 1 241 ? -13.382 -32.628 -40.309 1.00 33.72  ? 504  LEU A CG  1 
ATOM   1628 C  CD1 . LEU A 1 241 ? -12.502 -32.029 -41.383 1.00 33.30  ? 504  LEU A CD1 1 
ATOM   1629 C  CD2 . LEU A 1 241 ? -14.334 -33.614 -40.932 1.00 38.08  ? 504  LEU A CD2 1 
ATOM   1630 N  N   . SER A 1 242 ? -12.066 -33.948 -36.036 0.50 22.20  ? 505  SER A N   1 
ATOM   1631 C  CA  . SER A 1 242 ? -11.200 -34.449 -34.929 0.50 21.90  ? 505  SER A CA  1 
ATOM   1632 C  C   . SER A 1 242 ? -12.038 -34.950 -33.750 0.50 21.89  ? 505  SER A C   1 
ATOM   1633 O  O   . SER A 1 242 ? -11.495 -35.694 -32.905 0.50 19.49  ? 505  SER A O   1 
ATOM   1634 C  CB  . SER A 1 242 ? -10.231 -33.399 -34.474 0.50 21.76  ? 505  SER A CB  1 
ATOM   1635 O  OG  . SER A 1 242 ? -9.353  -33.055 -35.526 0.50 22.52  ? 505  SER A OG  1 
ATOM   1636 N  N   . GLY A 1 243 ? -13.297 -34.522 -33.654 1.00 22.10  ? 506  GLY A N   1 
ATOM   1637 C  CA  . GLY A 1 243 ? -14.152 -34.901 -32.518 1.00 20.82  ? 506  GLY A CA  1 
ATOM   1638 C  C   . GLY A 1 243 ? -14.633 -36.331 -32.587 1.00 21.08  ? 506  GLY A C   1 
ATOM   1639 O  O   . GLY A 1 243 ? -14.561 -36.969 -33.653 1.00 21.73  ? 506  GLY A O   1 
ATOM   1640 N  N   . VAL A 1 244 ? -15.179 -36.791 -31.461 1.00 21.77  ? 507  VAL A N   1 
ATOM   1641 C  CA  . VAL A 1 244 ? -15.783 -38.131 -31.336 1.00 22.92  ? 507  VAL A CA  1 
ATOM   1642 C  C   . VAL A 1 244 ? -17.080 -38.018 -30.520 1.00 24.24  ? 507  VAL A C   1 
ATOM   1643 O  O   . VAL A 1 244 ? -17.508 -39.034 -29.964 1.00 23.65  ? 507  VAL A O   1 
ATOM   1644 C  CB  . VAL A 1 244 ? -14.811 -39.147 -30.704 1.00 22.63  ? 507  VAL A CB  1 
ATOM   1645 C  CG1 . VAL A 1 244 ? -13.646 -39.415 -31.626 1.00 23.67  ? 507  VAL A CG1 1 
ATOM   1646 C  CG2 . VAL A 1 244 ? -14.344 -38.717 -29.316 1.00 24.23  ? 507  VAL A CG2 1 
ATOM   1647 N  N   . GLU A 1 245 ? -17.657 -36.828 -30.398 1.00 23.99  ? 508  GLU A N   1 
ATOM   1648 C  CA  . GLU A 1 245 ? -18.891 -36.672 -29.551 1.00 29.07  ? 508  GLU A CA  1 
ATOM   1649 C  C   . GLU A 1 245 ? -20.007 -37.564 -30.100 1.00 25.13  ? 508  GLU A C   1 
ATOM   1650 O  O   . GLU A 1 245 ? -20.224 -37.596 -31.319 1.00 25.18  ? 508  GLU A O   1 
ATOM   1651 C  CB  . GLU A 1 245 ? -19.356 -35.215 -29.478 1.00 31.04  ? 508  GLU A CB  1 
ATOM   1652 C  CG  . GLU A 1 245 ? -20.452 -34.974 -28.435 1.00 38.79  ? 508  GLU A CG  1 
ATOM   1653 C  CD  . GLU A 1 245 ? -21.871 -35.227 -28.916 1.00 40.19  ? 508  GLU A CD  1 
ATOM   1654 O  OE1 . GLU A 1 245 ? -22.170 -34.911 -30.072 1.00 49.85  ? 508  GLU A OE1 1 
ATOM   1655 O  OE2 . GLU A 1 245 ? -22.661 -35.794 -28.138 1.00 49.69  ? 508  GLU A OE2 1 
ATOM   1656 N  N   . GLY A 1 246 ? -20.637 -38.352 -29.233 1.00 30.86  ? 509  GLY A N   1 
ATOM   1657 C  CA  . GLY A 1 246 ? -21.708 -39.293 -29.646 1.00 30.94  ? 509  GLY A CA  1 
ATOM   1658 C  C   . GLY A 1 246 ? -21.246 -40.603 -30.271 1.00 29.59  ? 509  GLY A C   1 
ATOM   1659 O  O   . GLY A 1 246 ? -22.097 -41.408 -30.664 1.00 30.72  ? 509  GLY A O   1 
ATOM   1660 N  N   . GLU A 1 247 ? -19.924 -40.846 -30.242 0.50 26.92  ? 510  GLU A N   1 
ATOM   1661 C  CA  . GLU A 1 247 ? -19.279 -42.135 -30.608 0.50 26.66  ? 510  GLU A CA  1 
ATOM   1662 C  C   . GLU A 1 247 ? -19.183 -43.027 -29.364 0.50 26.60  ? 510  GLU A C   1 
ATOM   1663 O  O   . GLU A 1 247 ? -18.490 -42.645 -28.386 0.50 26.36  ? 510  GLU A O   1 
ATOM   1664 C  CB  . GLU A 1 247 ? -17.872 -41.925 -31.180 0.50 25.75  ? 510  GLU A CB  1 
ATOM   1665 C  CG  . GLU A 1 247 ? -17.842 -41.172 -32.505 0.50 28.30  ? 510  GLU A CG  1 
ATOM   1666 C  CD  . GLU A 1 247 ? -18.685 -41.778 -33.614 0.50 29.79  ? 510  GLU A CD  1 
ATOM   1667 O  OE1 . GLU A 1 247 ? -18.878 -43.006 -33.606 0.50 32.37  ? 510  GLU A OE1 1 
ATOM   1668 O  OE2 . GLU A 1 247 ? -19.187 -41.014 -34.458 0.50 32.49  ? 510  GLU A OE2 1 
ATOM   1669 N  N   . GLY A 1 248 ? -19.827 -44.190 -29.417 0.50 26.63  ? 511  GLY A N   1 
ATOM   1670 C  CA  . GLY A 1 248 ? -19.676 -45.242 -28.395 0.50 27.38  ? 511  GLY A CA  1 
ATOM   1671 C  C   . GLY A 1 248 ? -18.296 -45.876 -28.428 0.50 27.73  ? 511  GLY A C   1 
ATOM   1672 O  O   . GLY A 1 248 ? -17.561 -45.748 -29.440 0.50 23.40  ? 511  GLY A O   1 
ATOM   1673 N  N   A LEU A 1 249 ? -17.963 -46.581 -27.357 0.25 28.92  ? 512  LEU A N   1 
ATOM   1674 N  N   B LEU A 1 249 ? -17.910 -46.586 -27.349 0.25 28.29  ? 512  LEU A N   1 
ATOM   1675 C  CA  A LEU A 1 249 ? -16.657 -47.249 -27.196 0.25 29.08  ? 512  LEU A CA  1 
ATOM   1676 C  CA  B LEU A 1 249 ? -16.599 -47.279 -27.241 0.25 28.11  ? 512  LEU A CA  1 
ATOM   1677 C  C   A LEU A 1 249 ? -16.511 -48.284 -28.307 0.25 28.61  ? 512  LEU A C   1 
ATOM   1678 C  C   B LEU A 1 249 ? -16.480 -48.247 -28.401 0.25 28.03  ? 512  LEU A C   1 
ATOM   1679 O  O   A LEU A 1 249 ? -15.387 -48.743 -28.561 0.25 30.21  ? 512  LEU A O   1 
ATOM   1680 O  O   B LEU A 1 249 ? -15.360 -48.662 -28.738 0.25 29.01  ? 512  LEU A O   1 
ATOM   1681 C  CB  A LEU A 1 249 ? -16.642 -47.882 -25.805 0.25 29.48  ? 512  LEU A CB  1 
ATOM   1682 C  CB  B LEU A 1 249 ? -16.502 -48.047 -25.920 0.25 28.04  ? 512  LEU A CB  1 
ATOM   1683 C  CG  A LEU A 1 249 ? -15.272 -48.087 -25.187 0.25 28.82  ? 512  LEU A CG  1 
ATOM   1684 C  CG  B LEU A 1 249 ? -15.879 -47.275 -24.768 0.25 27.31  ? 512  LEU A CG  1 
ATOM   1685 C  CD1 A LEU A 1 249 ? -14.509 -46.772 -25.069 0.25 28.60  ? 512  LEU A CD1 1 
ATOM   1686 C  CD1 B LEU A 1 249 ? -16.134 -47.997 -23.454 0.25 26.72  ? 512  LEU A CD1 1 
ATOM   1687 C  CD2 A LEU A 1 249 ? -15.430 -48.760 -23.839 0.25 28.36  ? 512  LEU A CD2 1 
ATOM   1688 C  CD2 B LEU A 1 249 ? -14.385 -47.068 -25.008 0.25 27.15  ? 512  LEU A CD2 1 
ATOM   1689 N  N   . HIS A 1 250 ? -17.611 -48.635 -28.969 0.50 27.13  ? 513  HIS A N   1 
ATOM   1690 C  CA  . HIS A 1 250 ? -17.565 -49.635 -30.064 0.50 27.11  ? 513  HIS A CA  1 
ATOM   1691 C  C   . HIS A 1 250 ? -17.104 -48.972 -31.366 0.50 26.60  ? 513  HIS A C   1 
ATOM   1692 O  O   . HIS A 1 250 ? -16.889 -49.703 -32.361 0.50 27.07  ? 513  HIS A O   1 
ATOM   1693 C  CB  . HIS A 1 250 ? -18.919 -50.321 -30.258 0.50 29.25  ? 513  HIS A CB  1 
ATOM   1694 C  CG  . HIS A 1 250 ? -20.028 -49.363 -30.511 0.50 28.17  ? 513  HIS A CG  1 
ATOM   1695 N  ND1 . HIS A 1 250 ? -20.504 -48.526 -29.524 0.50 28.73  ? 513  HIS A ND1 1 
ATOM   1696 C  CD2 . HIS A 1 250 ? -20.750 -49.103 -31.622 0.50 30.03  ? 513  HIS A CD2 1 
ATOM   1697 C  CE1 . HIS A 1 250 ? -21.472 -47.783 -30.019 0.50 28.61  ? 513  HIS A CE1 1 
ATOM   1698 N  NE2 . HIS A 1 250 ? -21.651 -48.127 -31.304 0.50 29.33  ? 513  HIS A NE2 1 
ATOM   1699 N  N   . LYS A 1 251 ? -16.998 -47.641 -31.369 0.50 25.28  ? 514  LYS A N   1 
ATOM   1700 C  CA  . LYS A 1 251 ? -16.602 -46.850 -32.566 0.50 25.98  ? 514  LYS A CA  1 
ATOM   1701 C  C   . LYS A 1 251 ? -15.142 -46.409 -32.448 0.50 23.76  ? 514  LYS A C   1 
ATOM   1702 O  O   . LYS A 1 251 ? -14.470 -46.266 -33.504 0.50 23.89  ? 514  LYS A O   1 
ATOM   1703 C  CB  . LYS A 1 251 ? -17.494 -45.614 -32.700 0.50 28.34  ? 514  LYS A CB  1 
ATOM   1704 C  CG  . LYS A 1 251 ? -18.979 -45.934 -32.775 0.50 32.15  ? 514  LYS A CG  1 
ATOM   1705 C  CD  . LYS A 1 251 ? -19.294 -46.759 -33.980 0.50 33.61  ? 514  LYS A CD  1 
ATOM   1706 C  CE  . LYS A 1 251 ? -19.587 -45.885 -35.180 0.50 36.69  ? 514  LYS A CE  1 
ATOM   1707 N  NZ  . LYS A 1 251 ? -20.843 -45.128 -34.978 0.50 38.01  ? 514  LYS A NZ  1 
ATOM   1708 N  N   . LEU A 1 252 ? -14.671 -46.157 -31.226 0.50 21.46  ? 515  LEU A N   1 
ATOM   1709 C  CA  . LEU A 1 252 ? -13.405 -45.401 -31.014 0.50 21.36  ? 515  LEU A CA  1 
ATOM   1710 C  C   . LEU A 1 252 ? -12.216 -46.166 -31.606 0.50 20.85  ? 515  LEU A C   1 
ATOM   1711 O  O   . LEU A 1 252 ? -11.324 -45.506 -32.180 0.50 20.20  ? 515  LEU A O   1 
ATOM   1712 C  CB  . LEU A 1 252 ? -13.198 -45.113 -29.529 0.50 21.87  ? 515  LEU A CB  1 
ATOM   1713 C  CG  . LEU A 1 252 ? -14.235 -44.198 -28.881 0.50 22.77  ? 515  LEU A CG  1 
ATOM   1714 C  CD1 . LEU A 1 252 ? -13.829 -43.875 -27.452 0.50 23.88  ? 515  LEU A CD1 1 
ATOM   1715 C  CD2 . LEU A 1 252 ? -14.426 -42.916 -29.676 0.50 23.51  ? 515  LEU A CD2 1 
ATOM   1716 N  N   . GLY A 1 253 ? -12.184 -47.497 -31.467 1.00 20.09  ? 516  GLY A N   1 
ATOM   1717 C  CA  . GLY A 1 253 ? -11.078 -48.293 -32.018 1.00 20.47  ? 516  GLY A CA  1 
ATOM   1718 C  C   . GLY A 1 253 ? -11.050 -48.189 -33.546 1.00 21.27  ? 516  GLY A C   1 
ATOM   1719 O  O   . GLY A 1 253 ? -9.919  -48.012 -34.150 1.00 21.03  ? 516  GLY A O   1 
ATOM   1720 N  N   . TYR A 1 254 ? -12.211 -48.307 -34.184 1.00 20.65  ? 517  TYR A N   1 
ATOM   1721 C  CA  . TYR A 1 254 ? -12.273 -48.172 -35.659 1.00 21.13  ? 517  TYR A CA  1 
ATOM   1722 C  C   . TYR A 1 254 ? -11.809 -46.772 -36.096 1.00 20.38  ? 517  TYR A C   1 
ATOM   1723 O  O   . TYR A 1 254 ? -11.083 -46.650 -37.120 1.00 22.53  ? 517  TYR A O   1 
ATOM   1724 C  CB  . TYR A 1 254 ? -13.672 -48.425 -36.181 1.00 21.51  ? 517  TYR A CB  1 
ATOM   1725 C  CG  . TYR A 1 254 ? -14.129 -49.856 -36.180 1.00 20.59  ? 517  TYR A CG  1 
ATOM   1726 C  CD1 . TYR A 1 254 ? -13.615 -50.788 -37.088 1.00 22.94  ? 517  TYR A CD1 1 
ATOM   1727 C  CD2 . TYR A 1 254 ? -15.104 -50.268 -35.291 1.00 20.92  ? 517  TYR A CD2 1 
ATOM   1728 C  CE1 . TYR A 1 254 ? -14.049 -52.105 -37.096 1.00 22.98  ? 517  TYR A CE1 1 
ATOM   1729 C  CE2 . TYR A 1 254 ? -15.563 -51.574 -35.307 1.00 20.84  ? 517  TYR A CE2 1 
ATOM   1730 C  CZ  . TYR A 1 254 ? -15.076 -52.477 -36.235 1.00 21.80  ? 517  TYR A CZ  1 
ATOM   1731 O  OH  . TYR A 1 254 ? -15.552 -53.757 -36.245 1.00 23.45  ? 517  TYR A OH  1 
ATOM   1732 N  N   . ILE A 1 255 ? -12.140 -45.745 -35.325 1.00 22.32  ? 518  ILE A N   1 
ATOM   1733 C  CA  . ILE A 1 255 ? -11.686 -44.365 -35.612 1.00 21.92  ? 518  ILE A CA  1 
ATOM   1734 C  C   . ILE A 1 255 ? -10.150 -44.289 -35.511 1.00 23.67  ? 518  ILE A C   1 
ATOM   1735 O  O   . ILE A 1 255 ? -9.498  -43.709 -36.439 1.00 24.59  ? 518  ILE A O   1 
ATOM   1736 C  CB  . ILE A 1 255 ? -12.426 -43.365 -34.721 1.00 23.14  ? 518  ILE A CB  1 
ATOM   1737 C  CG1 . ILE A 1 255 ? -13.897 -43.275 -35.136 1.00 22.13  ? 518  ILE A CG1 1 
ATOM   1738 C  CG2 . ILE A 1 255 ? -11.707 -42.018 -34.698 1.00 24.37  ? 518  ILE A CG2 1 
ATOM   1739 C  CD1 . ILE A 1 255 ? -14.797 -42.571 -34.122 1.00 25.53  ? 518  ILE A CD1 1 
ATOM   1740 N  N   . LEU A 1 256 ? -9.548  -44.838 -34.461 1.00 22.44  ? 519  LEU A N   1 
ATOM   1741 C  CA  . LEU A 1 256 ? -8.070  -44.818 -34.333 1.00 22.64  ? 519  LEU A CA  1 
ATOM   1742 C  C   . LEU A 1 256 ? -7.442  -45.611 -35.478 1.00 25.64  ? 519  LEU A C   1 
ATOM   1743 O  O   . LEU A 1 256 ? -6.371  -45.166 -35.981 1.00 25.68  ? 519  LEU A O   1 
ATOM   1744 C  CB  . LEU A 1 256 ? -7.639  -45.389 -32.983 1.00 23.73  ? 519  LEU A CB  1 
ATOM   1745 C  CG  . LEU A 1 256 ? -7.999  -44.575 -31.746 1.00 26.92  ? 519  LEU A CG  1 
ATOM   1746 C  CD1 . LEU A 1 256 ? -7.378  -45.243 -30.519 1.00 30.47  ? 519  LEU A CD1 1 
ATOM   1747 C  CD2 . LEU A 1 256 ? -7.505  -43.127 -31.871 1.00 29.20  ? 519  LEU A CD2 1 
ATOM   1748 N  N   . ARG A 1 257 ? -8.035  -46.742 -35.887 1.00 23.92  ? 520  ARG A N   1 
ATOM   1749 C  CA  . ARG A 1 257 ? -7.449  -47.546 -36.996 1.00 25.53  ? 520  ARG A CA  1 
ATOM   1750 C  C   . ARG A 1 257 ? -7.514  -46.706 -38.295 1.00 25.20  ? 520  ARG A C   1 
ATOM   1751 O  O   . ARG A 1 257 ? -6.540  -46.728 -39.096 1.00 25.17  ? 520  ARG A O   1 
ATOM   1752 C  CB  . ARG A 1 257 ? -8.145  -48.898 -37.117 1.00 24.01  ? 520  ARG A CB  1 
ATOM   1753 C  CG  . ARG A 1 257 ? -7.544  -49.797 -38.199 1.00 26.67  ? 520  ARG A CG  1 
ATOM   1754 C  CD  . ARG A 1 257 ? -8.287  -51.108 -38.347 1.00 25.68  ? 520  ARG A CD  1 
ATOM   1755 N  NE  . ARG A 1 257 ? -9.592  -50.944 -38.947 1.00 26.38  ? 520  ARG A NE  1 
ATOM   1756 C  CZ  . ARG A 1 257 ? -10.384 -51.947 -39.355 1.00 24.81  ? 520  ARG A CZ  1 
ATOM   1757 N  NH1 . ARG A 1 257 ? -9.999  -53.197 -39.204 1.00 29.04  ? 520  ARG A NH1 1 
ATOM   1758 N  NH2 . ARG A 1 257 ? -11.529 -51.673 -39.926 1.00 26.46  ? 520  ARG A NH2 1 
ATOM   1759 N  N   . ASP A 1 258 ? -8.585  -45.950 -38.497 1.00 23.95  ? 521  ASP A N   1 
ATOM   1760 C  CA  . ASP A 1 258 ? -8.707  -45.067 -39.707 1.00 26.21  ? 521  ASP A CA  1 
ATOM   1761 C  C   . ASP A 1 258 ? -7.615  -43.970 -39.672 1.00 28.12  ? 521  ASP A C   1 
ATOM   1762 O  O   . ASP A 1 258 ? -7.010  -43.717 -40.709 1.00 29.05  ? 521  ASP A O   1 
ATOM   1763 C  CB  . ASP A 1 258 ? -10.096 -44.470 -39.861 1.00 27.19  ? 521  ASP A CB  1 
ATOM   1764 C  CG  . ASP A 1 258 ? -11.106 -45.383 -40.542 1.00 27.02  ? 521  ASP A CG  1 
ATOM   1765 O  OD1 . ASP A 1 258 ? -10.701 -46.456 -41.021 1.00 29.61  ? 521  ASP A OD1 1 
ATOM   1766 O  OD2 . ASP A 1 258 ? -12.267 -45.003 -40.558 1.00 29.52  ? 521  ASP A OD2 1 
ATOM   1767 N  N   . VAL A 1 259 ? -7.348  -43.350 -38.532 1.00 23.97  ? 522  VAL A N   1 
ATOM   1768 C  CA  . VAL A 1 259 ? -6.235  -42.362 -38.386 1.00 25.78  ? 522  VAL A CA  1 
ATOM   1769 C  C   . VAL A 1 259 ? -4.912  -43.059 -38.731 1.00 28.15  ? 522  VAL A C   1 
ATOM   1770 O  O   . VAL A 1 259 ? -4.099  -42.465 -39.480 1.00 30.19  ? 522  VAL A O   1 
ATOM   1771 C  CB  . VAL A 1 259 ? -6.204  -41.768 -36.972 1.00 25.96  ? 522  VAL A CB  1 
ATOM   1772 C  CG1 . VAL A 1 259 ? -4.912  -40.980 -36.702 1.00 28.07  ? 522  VAL A CG1 1 
ATOM   1773 C  CG2 . VAL A 1 259 ? -7.411  -40.898 -36.729 1.00 26.33  ? 522  VAL A CG2 1 
ATOM   1774 N  N   . SER A 1 260 ? -4.702  -44.300 -38.284 1.00 25.85  ? 523  SER A N   1 
ATOM   1775 C  CA  . SER A 1 260 ? -3.427  -45.030 -38.508 1.00 28.06  ? 523  SER A CA  1 
ATOM   1776 C  C   . SER A 1 260 ? -3.172  -45.221 -40.015 1.00 27.57  ? 523  SER A C   1 
ATOM   1777 O  O   . SER A 1 260 ? -2.011  -45.397 -40.363 1.00 28.51  ? 523  SER A O   1 
ATOM   1778 C  CB  . SER A 1 260 ? -3.376  -46.359 -37.809 1.00 27.59  ? 523  SER A CB  1 
ATOM   1779 O  OG  . SER A 1 260 ? -4.026  -47.380 -38.564 1.00 29.91  ? 523  SER A OG  1 
ATOM   1780 N  N   . LYS A 1 261 ? -4.205  -45.242 -40.842 1.00 28.22  ? 524  LYS A N   1 
ATOM   1781 C  CA  . LYS A 1 261 ? -4.089  -45.505 -42.301 1.00 32.69  ? 524  LYS A CA  1 
ATOM   1782 C  C   . LYS A 1 261 ? -3.478  -44.302 -43.033 1.00 33.95  ? 524  LYS A C   1 
ATOM   1783 O  O   . LYS A 1 261 ? -2.981  -44.502 -44.168 1.00 35.96  ? 524  LYS A O   1 
ATOM   1784 C  CB  . LYS A 1 261 ? -5.447  -45.818 -42.924 1.00 36.09  ? 524  LYS A CB  1 
ATOM   1785 C  CG  . LYS A 1 261 ? -6.016  -47.180 -42.589 1.00 40.29  ? 524  LYS A CG  1 
ATOM   1786 C  CD  . LYS A 1 261 ? -7.448  -47.257 -43.066 1.00 45.65  ? 524  LYS A CD  1 
ATOM   1787 C  CE  . LYS A 1 261 ? -8.152  -48.510 -42.616 1.00 52.80  ? 524  LYS A CE  1 
ATOM   1788 N  NZ  . LYS A 1 261 ? -9.614  -48.323 -42.756 1.00 66.78  ? 524  LYS A NZ  1 
ATOM   1789 N  N   . LYS A 1 262 ? -3.511  -43.122 -42.424 1.00 30.14  ? 525  LYS A N   1 
ATOM   1790 C  CA  . LYS A 1 262 ? -2.912  -41.896 -42.994 1.00 35.99  ? 525  LYS A CA  1 
ATOM   1791 C  C   . LYS A 1 262 ? -1.410  -42.120 -43.104 1.00 36.70  ? 525  LYS A C   1 
ATOM   1792 O  O   . LYS A 1 262 ? -0.840  -42.772 -42.229 1.00 33.81  ? 525  LYS A O   1 
ATOM   1793 C  CB  . LYS A 1 262 ? -3.227  -40.684 -42.127 1.00 35.13  ? 525  LYS A CB  1 
ATOM   1794 C  CG  . LYS A 1 262 ? -4.719  -40.398 -42.097 1.00 39.39  ? 525  LYS A CG  1 
ATOM   1795 C  CD  . LYS A 1 262 ? -5.094  -38.982 -42.290 1.00 43.43  ? 525  LYS A CD  1 
ATOM   1796 C  CE  . LYS A 1 262 ? -6.563  -38.822 -42.573 1.00 42.93  ? 525  LYS A CE  1 
ATOM   1797 N  NZ  . LYS A 1 262 ? -6.764  -37.747 -43.571 1.00 48.13  ? 525  LYS A NZ  1 
ATOM   1798 N  N   . GLU A 1 263 ? -0.782  -41.609 -44.151 1.00 36.70  ? 526  GLU A N   1 
ATOM   1799 C  CA  . GLU A 1 263 ? 0.702   -41.549 -44.176 1.00 36.35  ? 526  GLU A CA  1 
ATOM   1800 C  C   . GLU A 1 263 ? 1.147   -40.549 -43.094 1.00 33.08  ? 526  GLU A C   1 
ATOM   1801 O  O   . GLU A 1 263 ? 0.477   -39.535 -42.912 1.00 33.96  ? 526  GLU A O   1 
ATOM   1802 C  CB  . GLU A 1 263 ? 1.206   -41.145 -45.568 1.00 42.90  ? 526  GLU A CB  1 
ATOM   1803 C  CG  . GLU A 1 263 ? 0.853   -42.129 -46.674 1.00 48.61  ? 526  GLU A CG  1 
ATOM   1804 C  CD  . GLU A 1 263 ? 1.561   -43.479 -46.633 1.00 60.16  ? 526  GLU A CD  1 
ATOM   1805 O  OE1 . GLU A 1 263 ? 2.768   -43.520 -46.270 1.00 61.10  ? 526  GLU A OE1 1 
ATOM   1806 O  OE2 . GLU A 1 263 ? 0.900   -44.501 -46.970 1.00 62.05  ? 526  GLU A OE2 1 
ATOM   1807 N  N   . GLY A 1 264 ? 2.212   -40.854 -42.367 1.00 32.05  ? 527  GLY A N   1 
ATOM   1808 C  CA  . GLY A 1 264 ? 2.812   -39.874 -41.452 1.00 35.29  ? 527  GLY A CA  1 
ATOM   1809 C  C   . GLY A 1 264 ? 3.688   -40.548 -40.430 1.00 33.95  ? 527  GLY A C   1 
ATOM   1810 O  O   . GLY A 1 264 ? 4.163   -41.665 -40.691 1.00 34.05  ? 527  GLY A O   1 
ATOM   1811 N  N   . GLY A 1 265 ? 3.891   -39.897 -39.295 1.00 32.54  ? 528  GLY A N   1 
ATOM   1812 C  CA  . GLY A 1 265 ? 4.840   -40.381 -38.284 1.00 33.94  ? 528  GLY A CA  1 
ATOM   1813 C  C   . GLY A 1 265 ? 4.154   -41.281 -37.265 1.00 33.98  ? 528  GLY A C   1 
ATOM   1814 O  O   . GLY A 1 265 ? 3.126   -41.920 -37.618 1.00 34.20  ? 528  GLY A O   1 
ATOM   1815 N  N   . ALA A 1 266 ? 4.705   -41.333 -36.063 1.00 29.14  ? 529  ALA A N   1 
ATOM   1816 C  CA  . ALA A 1 266 ? 4.143   -42.086 -34.925 1.00 28.50  ? 529  ALA A CA  1 
ATOM   1817 C  C   . ALA A 1 266 ? 2.784   -41.496 -34.574 1.00 25.80  ? 529  ALA A C   1 
ATOM   1818 O  O   . ALA A 1 266 ? 2.436   -40.387 -35.041 1.00 24.15  ? 529  ALA A O   1 
ATOM   1819 C  CB  . ALA A 1 266 ? 5.065   -42.041 -33.748 1.00 27.17  ? 529  ALA A CB  1 
ATOM   1820 N  N   . MET A 1 267 ? 1.999   -42.231 -33.783 1.00 24.18  ? 530  MET A N   1 
ATOM   1821 C  CA  . MET A 1 267 ? 0.790   -41.669 -33.149 1.00 23.79  ? 530  MET A CA  1 
ATOM   1822 C  C   . MET A 1 267 ? 1.164   -41.156 -31.764 1.00 23.16  ? 530  MET A C   1 
ATOM   1823 O  O   . MET A 1 267 ? 1.729   -41.922 -30.960 1.00 30.51  ? 530  MET A O   1 
ATOM   1824 C  CB  . MET A 1 267 ? -0.318  -42.746 -33.112 1.00 25.53  ? 530  MET A CB  1 
ATOM   1825 C  CG  . MET A 1 267 ? -0.746  -43.143 -34.514 1.00 27.93  ? 530  MET A CG  1 
ATOM   1826 S  SD  . MET A 1 267 ? -2.047  -44.455 -34.646 1.00 33.92  ? 530  MET A SD  1 
ATOM   1827 C  CE  . MET A 1 267 ? -3.462  -43.584 -34.013 1.00 32.99  ? 530  MET A CE  1 
ATOM   1828 N  N   . TYR A 1 268 ? 0.846   -39.895 -31.475 1.00 20.83  ? 531  TYR A N   1 
ATOM   1829 C  CA  . TYR A 1 268 ? 1.169   -39.207 -30.221 1.00 20.89  ? 531  TYR A CA  1 
ATOM   1830 C  C   . TYR A 1 268 ? -0.099  -39.076 -29.386 1.00 21.87  ? 531  TYR A C   1 
ATOM   1831 O  O   . TYR A 1 268 ? -1.186  -38.679 -29.949 1.00 24.54  ? 531  TYR A O   1 
ATOM   1832 C  CB  . TYR A 1 268 ? 1.817   -37.858 -30.544 1.00 20.26  ? 531  TYR A CB  1 
ATOM   1833 C  CG  . TYR A 1 268 ? 3.141   -38.008 -31.249 1.00 23.98  ? 531  TYR A CG  1 
ATOM   1834 C  CD1 . TYR A 1 268 ? 3.221   -38.183 -32.621 1.00 22.26  ? 531  TYR A CD1 1 
ATOM   1835 C  CD2 . TYR A 1 268 ? 4.310   -38.113 -30.525 1.00 25.90  ? 531  TYR A CD2 1 
ATOM   1836 C  CE1 . TYR A 1 268 ? 4.438   -38.391 -33.256 1.00 24.26  ? 531  TYR A CE1 1 
ATOM   1837 C  CE2 . TYR A 1 268 ? 5.525   -38.349 -31.142 1.00 25.39  ? 531  TYR A CE2 1 
ATOM   1838 C  CZ  . TYR A 1 268 ? 5.600   -38.484 -32.511 1.00 29.06  ? 531  TYR A CZ  1 
ATOM   1839 O  OH  . TYR A 1 268 ? 6.821   -38.686 -33.124 1.00 26.55  ? 531  TYR A OH  1 
ATOM   1840 N  N   . ALA A 1 269 ? 0.005   -39.390 -28.104 1.00 21.97  ? 532  ALA A N   1 
ATOM   1841 C  CA  . ALA A 1 269 ? -1.125  -39.359 -27.157 1.00 22.48  ? 532  ALA A CA  1 
ATOM   1842 C  C   . ALA A 1 269 ? -0.636  -38.746 -25.868 1.00 26.88  ? 532  ALA A C   1 
ATOM   1843 O  O   . ALA A 1 269 ? -0.567  -39.444 -24.853 1.00 26.96  ? 532  ALA A O   1 
ATOM   1844 C  CB  . ALA A 1 269 ? -1.724  -40.742 -26.994 1.00 22.83  ? 532  ALA A CB  1 
ATOM   1845 N  N   . ASP A 1 270 ? -0.240  -37.483 -25.925 1.00 23.85  ? 533  ASP A N   1 
ATOM   1846 C  CA  . ASP A 1 270 ? 0.333   -36.806 -24.747 1.00 25.71  ? 533  ASP A CA  1 
ATOM   1847 C  C   . ASP A 1 270 ? -0.811  -36.330 -23.865 1.00 29.40  ? 533  ASP A C   1 
ATOM   1848 O  O   . ASP A 1 270 ? -1.639  -35.568 -24.332 1.00 28.60  ? 533  ASP A O   1 
ATOM   1849 C  CB  . ASP A 1 270 ? 1.220   -35.631 -25.177 1.00 27.68  ? 533  ASP A CB  1 
ATOM   1850 C  CG  . ASP A 1 270 ? 2.532   -36.057 -25.809 1.00 30.51  ? 533  ASP A CG  1 
ATOM   1851 O  OD1 . ASP A 1 270 ? 2.884   -37.269 -25.695 1.00 29.31  ? 533  ASP A OD1 1 
ATOM   1852 O  OD2 . ASP A 1 270 ? 3.157   -35.208 -26.454 1.00 29.88  ? 533  ASP A OD2 1 
ATOM   1853 N  N   . ASP A 1 271 ? -0.803  -36.705 -22.605 1.00 29.75  ? 534  ASP A N   1 
ATOM   1854 C  CA  . ASP A 1 271 ? -1.765  -36.176 -21.604 1.00 33.91  ? 534  ASP A CA  1 
ATOM   1855 C  C   . ASP A 1 271 ? -1.247  -34.831 -21.069 1.00 33.42  ? 534  ASP A C   1 
ATOM   1856 O  O   . ASP A 1 271 ? -0.030  -34.655 -20.944 1.00 31.46  ? 534  ASP A O   1 
ATOM   1857 C  CB  . ASP A 1 271 ? -1.998  -37.213 -20.507 1.00 36.60  ? 534  ASP A CB  1 
ATOM   1858 C  CG  . ASP A 1 271 ? -3.039  -38.258 -20.864 1.00 45.76  ? 534  ASP A CG  1 
ATOM   1859 O  OD1 . ASP A 1 271 ? -3.755  -38.084 -21.899 1.00 47.05  ? 534  ASP A OD1 1 
ATOM   1860 O  OD2 . ASP A 1 271 ? -3.145  -39.238 -20.121 1.00 47.83  ? 534  ASP A OD2 1 
ATOM   1861 N  N   . THR A 1 272 ? -2.147  -33.871 -20.855 1.00 29.00  ? 535  THR A N   1 
ATOM   1862 C  CA  . THR A 1 272 ? -1.830  -32.581 -20.197 1.00 28.71  ? 535  THR A CA  1 
ATOM   1863 C  C   . THR A 1 272 ? -1.912  -32.787 -18.688 1.00 28.55  ? 535  THR A C   1 
ATOM   1864 O  O   . THR A 1 272 ? -2.830  -33.437 -18.242 1.00 29.29  ? 535  THR A O   1 
ATOM   1865 C  CB  . THR A 1 272 ? -2.769  -31.480 -20.682 1.00 29.95  ? 535  THR A CB  1 
ATOM   1866 O  OG1 . THR A 1 272 ? -2.595  -31.389 -22.093 1.00 30.39  ? 535  THR A OG1 1 
ATOM   1867 C  CG2 . THR A 1 272 ? -2.478  -30.133 -20.073 1.00 28.89  ? 535  THR A CG2 1 
ATOM   1868 N  N   . ALA A 1 273 ? -0.977  -32.219 -17.929 1.00 34.18  ? 536  ALA A N   1 
ATOM   1869 C  CA  . ALA A 1 273 ? -1.074  -32.153 -16.456 1.00 37.85  ? 536  ALA A CA  1 
ATOM   1870 C  C   . ALA A 1 273 ? -2.147  -31.105 -16.078 1.00 34.37  ? 536  ALA A C   1 
ATOM   1871 O  O   . ALA A 1 273 ? -1.938  -29.918 -16.328 1.00 38.11  ? 536  ALA A O   1 
ATOM   1872 C  CB  . ALA A 1 273 ? 0.308   -31.870 -15.899 1.00 36.52  ? 536  ALA A CB  1 
ATOM   1873 N  N   . GLY A 1 274 ? -3.282  -31.557 -15.561 1.00 33.48  ? 537  GLY A N   1 
ATOM   1874 C  CA  . GLY A 1 274 ? -4.368  -30.725 -14.998 1.00 34.84  ? 537  GLY A CA  1 
ATOM   1875 C  C   . GLY A 1 274 ? -4.930  -29.748 -16.015 1.00 35.38  ? 537  GLY A C   1 
ATOM   1876 O  O   . GLY A 1 274 ? -4.936  -28.506 -15.760 1.00 34.56  ? 537  GLY A O   1 
ATOM   1877 N  N   . TRP A 1 275 ? -5.458  -30.272 -17.118 1.00 31.47  ? 538  TRP A N   1 
ATOM   1878 C  CA  . TRP A 1 275 ? -5.935  -29.433 -18.250 1.00 30.70  ? 538  TRP A CA  1 
ATOM   1879 C  C   . TRP A 1 275 ? -6.796  -28.241 -17.773 1.00 28.39  ? 538  TRP A C   1 
ATOM   1880 O  O   . TRP A 1 275 ? -6.541  -27.108 -18.237 1.00 30.10  ? 538  TRP A O   1 
ATOM   1881 C  CB  . TRP A 1 275 ? -6.696  -30.296 -19.245 1.00 27.58  ? 538  TRP A CB  1 
ATOM   1882 C  CG  . TRP A 1 275 ? -7.294  -29.468 -20.341 1.00 27.91  ? 538  TRP A CG  1 
ATOM   1883 C  CD1 . TRP A 1 275 ? -8.507  -28.858 -20.304 1.00 29.74  ? 538  TRP A CD1 1 
ATOM   1884 C  CD2 . TRP A 1 275 ? -6.760  -29.210 -21.645 1.00 25.58  ? 538  TRP A CD2 1 
ATOM   1885 N  NE1 . TRP A 1 275 ? -8.745  -28.218 -21.485 1.00 29.80  ? 538  TRP A NE1 1 
ATOM   1886 C  CE2 . TRP A 1 275 ? -7.689  -28.395 -22.322 1.00 28.15  ? 538  TRP A CE2 1 
ATOM   1887 C  CE3 . TRP A 1 275 ? -5.607  -29.581 -22.331 1.00 26.05  ? 538  TRP A CE3 1 
ATOM   1888 C  CZ2 . TRP A 1 275 ? -7.500  -27.969 -23.633 1.00 27.39  ? 538  TRP A CZ2 1 
ATOM   1889 C  CZ3 . TRP A 1 275 ? -5.417  -29.144 -23.622 1.00 25.20  ? 538  TRP A CZ3 1 
ATOM   1890 C  CH2 . TRP A 1 275 ? -6.341  -28.335 -24.262 1.00 29.92  ? 538  TRP A CH2 1 
ATOM   1891 N  N   . ASP A 1 276 ? -7.827  -28.482 -16.986 1.00 31.56  ? 539  ASP A N   1 
ATOM   1892 C  CA  . ASP A 1 276 ? -8.829  -27.450 -16.560 1.00 33.30  ? 539  ASP A CA  1 
ATOM   1893 C  C   . ASP A 1 276 ? -8.102  -26.279 -15.862 1.00 39.66  ? 539  ASP A C   1 
ATOM   1894 O  O   . ASP A 1 276 ? -8.469  -25.101 -16.086 1.00 35.58  ? 539  ASP A O   1 
ATOM   1895 C  CB  . ASP A 1 276 ? -9.919  -28.093 -15.709 1.00 35.31  ? 539  ASP A CB  1 
ATOM   1896 C  CG  . ASP A 1 276 ? -10.963 -28.829 -16.551 1.00 38.76  ? 539  ASP A CG  1 
ATOM   1897 O  OD1 . ASP A 1 276 ? -10.854 -28.814 -17.806 1.00 38.48  ? 539  ASP A OD1 1 
ATOM   1898 O  OD2 . ASP A 1 276 ? -11.858 -29.424 -15.970 1.00 47.92  ? 539  ASP A OD2 1 
ATOM   1899 N  N   . THR A 1 277 ? -7.014  -26.556 -15.147 1.00 37.10  ? 540  THR A N   1 
ATOM   1900 C  CA  . THR A 1 277 ? -6.233  -25.509 -14.429 1.00 37.95  ? 540  THR A CA  1 
ATOM   1901 C  C   . THR A 1 277 ? -5.280  -24.738 -15.355 1.00 39.39  ? 540  THR A C   1 
ATOM   1902 O  O   . THR A 1 277 ? -4.742  -23.726 -14.910 1.00 40.91  ? 540  THR A O   1 
ATOM   1903 C  CB  . THR A 1 277 ? -5.452  -26.090 -13.234 1.00 38.31  ? 540  THR A CB  1 
ATOM   1904 O  OG1 . THR A 1 277 ? -4.438  -26.981 -13.685 1.00 42.74  ? 540  THR A OG1 1 
ATOM   1905 C  CG2 . THR A 1 277 ? -6.328  -26.841 -12.265 1.00 40.92  ? 540  THR A CG2 1 
ATOM   1906 N  N   . ARG A 1 278 ? -5.084  -25.206 -16.595 0.50 36.82  ? 541  ARG A N   1 
ATOM   1907 C  CA  . ARG A 1 278 ? -4.158  -24.597 -17.589 0.50 36.46  ? 541  ARG A CA  1 
ATOM   1908 C  C   . ARG A 1 278 ? -4.931  -23.799 -18.644 0.50 34.85  ? 541  ARG A C   1 
ATOM   1909 O  O   . ARG A 1 278 ? -4.284  -23.361 -19.606 0.50 33.34  ? 541  ARG A O   1 
ATOM   1910 C  CB  . ARG A 1 278 ? -3.338  -25.681 -18.296 0.50 39.05  ? 541  ARG A CB  1 
ATOM   1911 C  CG  . ARG A 1 278 ? -2.694  -26.691 -17.360 0.50 42.16  ? 541  ARG A CG  1 
ATOM   1912 C  CD  . ARG A 1 278 ? -1.420  -26.169 -16.734 0.50 44.18  ? 541  ARG A CD  1 
ATOM   1913 N  NE  . ARG A 1 278 ? -0.622  -27.234 -16.137 0.50 45.73  ? 541  ARG A NE  1 
ATOM   1914 C  CZ  . ARG A 1 278 ? 0.696   -27.188 -16.017 0.50 46.23  ? 541  ARG A CZ  1 
ATOM   1915 N  NH1 . ARG A 1 278 ? 1.361   -26.144 -16.484 0.50 47.66  ? 541  ARG A NH1 1 
ATOM   1916 N  NH2 . ARG A 1 278 ? 1.347   -28.185 -15.447 0.50 47.91  ? 541  ARG A NH2 1 
ATOM   1917 N  N   . ILE A 1 279 ? -6.254  -23.656 -18.495 1.00 33.52  ? 542  ILE A N   1 
ATOM   1918 C  CA  . ILE A 1 279 ? -7.088  -22.826 -19.414 1.00 34.76  ? 542  ILE A CA  1 
ATOM   1919 C  C   . ILE A 1 279 ? -6.797  -21.360 -19.059 1.00 33.97  ? 542  ILE A C   1 
ATOM   1920 O  O   . ILE A 1 279 ? -7.028  -20.968 -17.918 1.00 36.53  ? 542  ILE A O   1 
ATOM   1921 C  CB  . ILE A 1 279 ? -8.579  -23.216 -19.329 1.00 32.38  ? 542  ILE A CB  1 
ATOM   1922 C  CG1 . ILE A 1 279 ? -8.812  -24.567 -20.012 1.00 34.01  ? 542  ILE A CG1 1 
ATOM   1923 C  CG2 . ILE A 1 279 ? -9.508  -22.148 -19.915 1.00 34.53  ? 542  ILE A CG2 1 
ATOM   1924 C  CD1 . ILE A 1 279 ? -8.596  -24.526 -21.498 1.00 33.62  ? 542  ILE A CD1 1 
ATOM   1925 N  N   . THR A 1 280 ? -6.236  -20.609 -19.993 1.00 36.53  ? 543  THR A N   1 
ATOM   1926 C  CA  . THR A 1 280 ? -5.809  -19.201 -19.772 1.00 39.45  ? 543  THR A CA  1 
ATOM   1927 C  C   . THR A 1 280 ? -6.966  -18.240 -20.058 1.00 39.23  ? 543  THR A C   1 
ATOM   1928 O  O   . THR A 1 280 ? -7.990  -18.646 -20.682 1.00 34.23  ? 543  THR A O   1 
ATOM   1929 C  CB  . THR A 1 280 ? -4.602  -18.855 -20.641 1.00 35.02  ? 543  THR A CB  1 
ATOM   1930 O  OG1 . THR A 1 280 ? -4.969  -18.967 -22.014 1.00 34.63  ? 543  THR A OG1 1 
ATOM   1931 C  CG2 . THR A 1 280 ? -3.415  -19.741 -20.364 1.00 40.84  ? 543  THR A CG2 1 
ATOM   1932 N  N   . LEU A 1 281 ? -6.820  -16.969 -19.689 1.00 39.94  ? 544  LEU A N   1 
ATOM   1933 C  CA  . LEU A 1 281 ? -7.864  -15.976 -20.046 1.00 40.46  ? 544  LEU A CA  1 
ATOM   1934 C  C   . LEU A 1 281 ? -7.866  -15.823 -21.576 1.00 35.10  ? 544  LEU A C   1 
ATOM   1935 O  O   . LEU A 1 281 ? -8.913  -15.593 -22.138 1.00 35.56  ? 544  LEU A O   1 
ATOM   1936 C  CB  . LEU A 1 281 ? -7.580  -14.658 -19.309 1.00 51.58  ? 544  LEU A CB  1 
ATOM   1937 C  CG  . LEU A 1 281 ? -8.499  -13.485 -19.655 1.00 57.71  ? 544  LEU A CG  1 
ATOM   1938 C  CD1 . LEU A 1 281 ? -9.981  -13.857 -19.526 1.00 56.72  ? 544  LEU A CD1 1 
ATOM   1939 C  CD2 . LEU A 1 281 ? -8.167  -12.274 -18.785 1.00 57.94  ? 544  LEU A CD2 1 
ATOM   1940 N  N   . GLU A 1 282 ? -6.734  -16.019 -22.256 1.00 34.14  ? 545  GLU A N   1 
ATOM   1941 C  CA  . GLU A 1 282 ? -6.686  -15.940 -23.740 1.00 36.98  ? 545  GLU A CA  1 
ATOM   1942 C  C   . GLU A 1 282 ? -7.535  -17.063 -24.368 1.00 38.10  ? 545  GLU A C   1 
ATOM   1943 O  O   . GLU A 1 282 ? -8.284  -16.811 -25.336 1.00 34.23  ? 545  GLU A O   1 
ATOM   1944 C  CB  . GLU A 1 282 ? -5.229  -16.018 -24.176 1.00 45.17  ? 545  GLU A CB  1 
ATOM   1945 C  CG  . GLU A 1 282 ? -4.979  -15.395 -25.519 1.00 55.79  ? 545  GLU A CG  1 
ATOM   1946 C  CD  . GLU A 1 282 ? -5.230  -13.898 -25.598 1.00 56.16  ? 545  GLU A CD  1 
ATOM   1947 O  OE1 . GLU A 1 282 ? -5.182  -13.215 -24.547 1.00 58.70  ? 545  GLU A OE1 1 
ATOM   1948 O  OE2 . GLU A 1 282 ? -5.496  -13.439 -26.718 1.00 56.51  ? 545  GLU A OE2 1 
ATOM   1949 N  N   . ASP A 1 283 ? -7.394  -18.285 -23.857 1.00 36.07  ? 546  ASP A N   1 
ATOM   1950 C  CA  . ASP A 1 283 ? -8.257  -19.441 -24.231 1.00 32.66  ? 546  ASP A CA  1 
ATOM   1951 C  C   . ASP A 1 283 ? -9.750  -19.088 -24.058 1.00 32.39  ? 546  ASP A C   1 
ATOM   1952 O  O   . ASP A 1 283 ? -10.526 -19.334 -25.002 1.00 34.87  ? 546  ASP A O   1 
ATOM   1953 C  CB  . ASP A 1 283 ? -7.927  -20.655 -23.359 1.00 31.76  ? 546  ASP A CB  1 
ATOM   1954 C  CG  . ASP A 1 283 ? -6.555  -21.295 -23.588 1.00 30.42  ? 546  ASP A CG  1 
ATOM   1955 O  OD1 . ASP A 1 283 ? -6.016  -21.207 -24.731 1.00 30.02  ? 546  ASP A OD1 1 
ATOM   1956 O  OD2 . ASP A 1 283 ? -6.100  -21.985 -22.643 1.00 29.97  ? 546  ASP A OD2 1 
ATOM   1957 N  N   . LEU A 1 284 ? -10.156 -18.540 -22.912 1.00 33.63  ? 547  LEU A N   1 
ATOM   1958 C  CA  . LEU A 1 284 ? -11.577 -18.153 -22.662 1.00 36.27  ? 547  LEU A CA  1 
ATOM   1959 C  C   . LEU A 1 284 ? -12.083 -17.119 -23.694 1.00 35.98  ? 547  LEU A C   1 
ATOM   1960 O  O   . LEU A 1 284 ? -13.255 -17.218 -24.109 1.00 38.43  ? 547  LEU A O   1 
ATOM   1961 C  CB  . LEU A 1 284 ? -11.747 -17.667 -21.222 1.00 38.41  ? 547  LEU A CB  1 
ATOM   1962 C  CG  . LEU A 1 284 ? -11.410 -18.689 -20.133 1.00 39.35  ? 547  LEU A CG  1 
ATOM   1963 C  CD1 . LEU A 1 284 ? -11.351 -18.011 -18.780 1.00 46.77  ? 547  LEU A CD1 1 
ATOM   1964 C  CD2 . LEU A 1 284 ? -12.403 -19.842 -20.089 1.00 37.66  ? 547  LEU A CD2 1 
ATOM   1965 N  N   . LYS A 1 285 ? -11.222 -16.169 -24.084 0.50 36.05  ? 548  LYS A N   1 
ATOM   1966 C  CA  . LYS A 1 285 ? -11.524 -15.112 -25.090 0.50 36.15  ? 548  LYS A CA  1 
ATOM   1967 C  C   . LYS A 1 285 ? -11.702 -15.760 -26.468 0.50 35.61  ? 548  LYS A C   1 
ATOM   1968 O  O   . LYS A 1 285 ? -12.670 -15.400 -27.163 0.50 33.05  ? 548  LYS A O   1 
ATOM   1969 C  CB  . LYS A 1 285 ? -10.434 -14.033 -25.090 0.50 38.84  ? 548  LYS A CB  1 
ATOM   1970 C  CG  . LYS A 1 285 ? -10.437 -13.129 -23.864 0.50 41.42  ? 548  LYS A CG  1 
ATOM   1971 C  CD  . LYS A 1 285 ? -9.237  -12.209 -23.760 0.50 43.63  ? 548  LYS A CD  1 
ATOM   1972 C  CE  . LYS A 1 285 ? -9.313  -11.268 -22.574 0.50 45.61  ? 548  LYS A CE  1 
ATOM   1973 N  NZ  . LYS A 1 285 ? -8.025  -10.571 -22.333 0.50 48.08  ? 548  LYS A NZ  1 
ATOM   1974 N  N   . ASN A 1 286 ? -10.835 -16.711 -26.837 1.00 32.54  ? 549  ASN A N   1 
ATOM   1975 C  CA  . ASN A 1 286 ? -10.983 -17.422 -28.131 1.00 31.82  ? 549  ASN A CA  1 
ATOM   1976 C  C   . ASN A 1 286 ? -12.253 -18.293 -28.126 1.00 27.42  ? 549  ASN A C   1 
ATOM   1977 O  O   . ASN A 1 286 ? -12.899 -18.381 -29.173 1.00 29.95  ? 549  ASN A O   1 
ATOM   1978 C  CB  . ASN A 1 286 ? -9.718  -18.196 -28.484 1.00 31.57  ? 549  ASN A CB  1 
ATOM   1979 C  CG  . ASN A 1 286 ? -8.561  -17.246 -28.715 1.00 40.35  ? 549  ASN A CG  1 
ATOM   1980 O  OD1 . ASN A 1 286 ? -8.745  -16.169 -29.283 1.00 38.21  ? 549  ASN A OD1 1 
ATOM   1981 N  ND2 . ASN A 1 286 ? -7.365  -17.641 -28.315 1.00 34.39  ? 549  ASN A ND2 1 
ATOM   1982 N  N   . GLU A 1 287 ? -12.601 -18.942 -27.018 1.00 28.92  ? 550  GLU A N   1 
ATOM   1983 C  CA  . GLU A 1 287 ? -13.837 -19.770 -26.927 1.00 30.55  ? 550  GLU A CA  1 
ATOM   1984 C  C   . GLU A 1 287 ? -15.068 -18.844 -27.116 1.00 31.42  ? 550  GLU A C   1 
ATOM   1985 O  O   . GLU A 1 287 ? -16.026 -19.218 -27.869 1.00 28.68  ? 550  GLU A O   1 
ATOM   1986 C  CB  . GLU A 1 287 ? -13.839 -20.524 -25.598 1.00 28.79  ? 550  GLU A CB  1 
ATOM   1987 C  CG  . GLU A 1 287 ? -12.792 -21.632 -25.565 1.00 29.10  ? 550  GLU A CG  1 
ATOM   1988 C  CD  . GLU A 1 287 ? -12.533 -22.199 -24.185 1.00 30.07  ? 550  GLU A CD  1 
ATOM   1989 O  OE1 . GLU A 1 287 ? -13.224 -21.783 -23.229 1.00 34.92  ? 550  GLU A OE1 1 
ATOM   1990 O  OE2 . GLU A 1 287 ? -11.613 -23.074 -24.045 1.00 34.51  ? 550  GLU A OE2 1 
ATOM   1991 N  N   . GLU A 1 288 ? -15.015 -17.660 -26.501 0.50 33.13  ? 551  GLU A N   1 
ATOM   1992 C  CA  . GLU A 1 288 ? -16.083 -16.620 -26.541 0.50 34.44  ? 551  GLU A CA  1 
ATOM   1993 C  C   . GLU A 1 288 ? -16.425 -16.240 -27.988 0.50 34.31  ? 551  GLU A C   1 
ATOM   1994 O  O   . GLU A 1 288 ? -17.592 -15.867 -28.232 0.50 36.09  ? 551  GLU A O   1 
ATOM   1995 C  CB  . GLU A 1 288 ? -15.641 -15.395 -25.737 0.50 37.17  ? 551  GLU A CB  1 
ATOM   1996 C  CG  . GLU A 1 288 ? -16.783 -14.462 -25.361 0.50 39.53  ? 551  GLU A CG  1 
ATOM   1997 C  CD  . GLU A 1 288 ? -17.066 -13.348 -26.355 0.50 42.98  ? 551  GLU A CD  1 
ATOM   1998 O  OE1 . GLU A 1 288 ? -16.209 -13.107 -27.235 0.50 41.92  ? 551  GLU A OE1 1 
ATOM   1999 O  OE2 . GLU A 1 288 ? -18.146 -12.716 -26.240 0.50 43.20  ? 551  GLU A OE2 1 
ATOM   2000 N  N   . MET A 1 289 ? -15.471 -16.340 -28.918 1.00 32.64  ? 552  MET A N   1 
ATOM   2001 C  CA  . MET A 1 289 ? -15.712 -15.980 -30.345 1.00 33.31  ? 552  MET A CA  1 
ATOM   2002 C  C   . MET A 1 289 ? -16.838 -16.800 -30.988 1.00 34.31  ? 552  MET A C   1 
ATOM   2003 O  O   . MET A 1 289 ? -17.294 -16.418 -32.102 1.00 36.52  ? 552  MET A O   1 
ATOM   2004 C  CB  . MET A 1 289 ? -14.426 -16.069 -31.179 1.00 35.83  ? 552  MET A CB  1 
ATOM   2005 C  CG  . MET A 1 289 ? -13.376 -15.098 -30.678 1.00 40.48  ? 552  MET A CG  1 
ATOM   2006 S  SD  . MET A 1 289 ? -12.144 -14.664 -31.962 1.00 47.88  ? 552  MET A SD  1 
ATOM   2007 C  CE  . MET A 1 289 ? -11.524 -16.297 -32.333 1.00 43.64  ? 552  MET A CE  1 
ATOM   2008 N  N   . VAL A 1 290 ? -17.329 -17.879 -30.363 1.00 30.81  ? 553  VAL A N   1 
ATOM   2009 C  CA  . VAL A 1 290 ? -18.523 -18.573 -30.917 1.00 29.92  ? 553  VAL A CA  1 
ATOM   2010 C  C   . VAL A 1 290 ? -19.685 -17.555 -30.999 1.00 28.77  ? 553  VAL A C   1 
ATOM   2011 O  O   . VAL A 1 290 ? -20.533 -17.705 -31.919 1.00 35.38  ? 553  VAL A O   1 
ATOM   2012 C  CB  . VAL A 1 290 ? -18.898 -19.850 -30.141 1.00 26.88  ? 553  VAL A CB  1 
ATOM   2013 C  CG1 . VAL A 1 290 ? -19.348 -19.605 -28.708 1.00 28.21  ? 553  VAL A CG1 1 
ATOM   2014 C  CG2 . VAL A 1 290 ? -19.933 -20.634 -30.899 1.00 27.57  ? 553  VAL A CG2 1 
ATOM   2015 N  N   . THR A 1 291 ? -19.745 -16.587 -30.087 1.00 31.95  ? 554  THR A N   1 
ATOM   2016 C  CA  . THR A 1 291 ? -20.842 -15.553 -30.057 1.00 33.66  ? 554  THR A CA  1 
ATOM   2017 C  C   . THR A 1 291 ? -20.841 -14.695 -31.334 1.00 35.95  ? 554  THR A C   1 
ATOM   2018 O  O   . THR A 1 291 ? -21.926 -14.106 -31.647 1.00 36.37  ? 554  THR A O   1 
ATOM   2019 C  CB  . THR A 1 291 ? -20.750 -14.619 -28.846 1.00 33.81  ? 554  THR A CB  1 
ATOM   2020 O  OG1 . THR A 1 291 ? -19.494 -13.960 -28.995 1.00 33.59  ? 554  THR A OG1 1 
ATOM   2021 C  CG2 . THR A 1 291 ? -20.854 -15.312 -27.506 1.00 33.73  ? 554  THR A CG2 1 
ATOM   2022 N  N   . ASN A 1 292 ? -19.711 -14.598 -32.044 1.00 37.99  ? 555  ASN A N   1 
ATOM   2023 C  CA  . ASN A 1 292 ? -19.612 -13.894 -33.356 1.00 41.20  ? 555  ASN A CA  1 
ATOM   2024 C  C   . ASN A 1 292 ? -20.549 -14.520 -34.395 1.00 45.38  ? 555  ASN A C   1 
ATOM   2025 O  O   . ASN A 1 292 ? -20.767 -13.890 -35.442 1.00 43.80  ? 555  ASN A O   1 
ATOM   2026 C  CB  . ASN A 1 292 ? -18.212 -13.940 -33.969 1.00 39.23  ? 555  ASN A CB  1 
ATOM   2027 C  CG  . ASN A 1 292 ? -17.195 -13.210 -33.131 1.00 38.64  ? 555  ASN A CG  1 
ATOM   2028 O  OD1 . ASN A 1 292 ? -17.547 -12.554 -32.148 1.00 44.15  ? 555  ASN A OD1 1 
ATOM   2029 N  ND2 . ASN A 1 292 ? -15.932 -13.349 -33.486 1.00 39.56  ? 555  ASN A ND2 1 
ATOM   2030 N  N   . HIS A 1 293 ? -21.012 -15.746 -34.167 1.00 38.35  ? 556  HIS A N   1 
ATOM   2031 C  CA  . HIS A 1 293 ? -21.859 -16.516 -35.106 1.00 43.86  ? 556  HIS A CA  1 
ATOM   2032 C  C   . HIS A 1 293 ? -23.332 -16.447 -34.688 1.00 35.06  ? 556  HIS A C   1 
ATOM   2033 O  O   . HIS A 1 293 ? -24.151 -17.147 -35.297 1.00 39.18  ? 556  HIS A O   1 
ATOM   2034 C  CB  . HIS A 1 293 ? -21.326 -17.952 -35.179 1.00 40.65  ? 556  HIS A CB  1 
ATOM   2035 C  CG  . HIS A 1 293 ? -19.964 -17.984 -35.767 1.00 42.90  ? 556  HIS A CG  1 
ATOM   2036 N  ND1 . HIS A 1 293 ? -19.765 -18.153 -37.125 1.00 46.20  ? 556  HIS A ND1 1 
ATOM   2037 C  CD2 . HIS A 1 293 ? -18.741 -17.810 -35.208 1.00 42.33  ? 556  HIS A CD2 1 
ATOM   2038 C  CE1 . HIS A 1 293 ? -18.471 -18.121 -37.373 1.00 43.77  ? 556  HIS A CE1 1 
ATOM   2039 N  NE2 . HIS A 1 293 ? -17.824 -17.897 -36.220 1.00 40.68  ? 556  HIS A NE2 1 
ATOM   2040 N  N   . MET A 1 294 ? -23.636 -15.711 -33.631 1.00 33.94  ? 557  MET A N   1 
ATOM   2041 C  CA  . MET A 1 294 ? -24.994 -15.674 -33.061 1.00 34.48  ? 557  MET A CA  1 
ATOM   2042 C  C   . MET A 1 294 ? -25.662 -14.352 -33.460 1.00 41.18  ? 557  MET A C   1 
ATOM   2043 O  O   . MET A 1 294 ? -25.020 -13.577 -34.133 1.00 39.08  ? 557  MET A O   1 
ATOM   2044 C  CB  . MET A 1 294 ? -24.935 -15.795 -31.546 1.00 36.48  ? 557  MET A CB  1 
ATOM   2045 C  CG  . MET A 1 294 ? -24.327 -17.138 -31.094 1.00 33.17  ? 557  MET A CG  1 
ATOM   2046 S  SD  . MET A 1 294 ? -24.251 -17.117 -29.325 1.00 33.59  ? 557  MET A SD  1 
ATOM   2047 C  CE  . MET A 1 294 ? -23.228 -18.575 -29.040 1.00 35.58  ? 557  MET A CE  1 
ATOM   2048 N  N   . GLU A 1 295 ? -26.917 -14.163 -33.068 1.00 45.29  ? 558  GLU A N   1 
ATOM   2049 C  CA  . GLU A 1 295 ? -27.696 -12.929 -33.349 1.00 47.31  ? 558  GLU A CA  1 
ATOM   2050 C  C   . GLU A 1 295 ? -28.745 -12.750 -32.265 1.00 47.22  ? 558  GLU A C   1 
ATOM   2051 O  O   . GLU A 1 295 ? -29.048 -13.729 -31.547 1.00 44.49  ? 558  GLU A O   1 
ATOM   2052 C  CB  . GLU A 1 295 ? -28.331 -13.009 -34.734 1.00 47.65  ? 558  GLU A CB  1 
ATOM   2053 C  CG  . GLU A 1 295 ? -29.430 -14.030 -34.856 1.00 47.77  ? 558  GLU A CG  1 
ATOM   2054 C  CD  . GLU A 1 295 ? -29.937 -14.224 -36.276 1.00 62.79  ? 558  GLU A CD  1 
ATOM   2055 O  OE1 . GLU A 1 295 ? -29.113 -14.191 -37.247 1.00 64.13  ? 558  GLU A OE1 1 
ATOM   2056 O  OE2 . GLU A 1 295 ? -31.161 -14.410 -36.413 1.00 66.95  ? 558  GLU A OE2 1 
ATOM   2057 N  N   . GLY A 1 296 ? -29.290 -11.532 -32.190 1.00 55.66  ? 559  GLY A N   1 
ATOM   2058 C  CA  . GLY A 1 296 ? -30.440 -11.175 -31.348 1.00 50.29  ? 559  GLY A CA  1 
ATOM   2059 C  C   . GLY A 1 296 ? -30.147 -11.389 -29.881 1.00 49.65  ? 559  GLY A C   1 
ATOM   2060 O  O   . GLY A 1 296 ? -28.964 -11.180 -29.469 1.00 52.37  ? 559  GLY A O   1 
ATOM   2061 N  N   . GLU A 1 297 ? -31.187 -11.833 -29.170 1.00 46.60  ? 560  GLU A N   1 
ATOM   2062 C  CA  . GLU A 1 297 ? -31.213 -12.227 -27.745 1.00 51.32  ? 560  GLU A CA  1 
ATOM   2063 C  C   . GLU A 1 297 ? -30.101 -13.258 -27.481 1.00 54.85  ? 560  GLU A C   1 
ATOM   2064 O  O   . GLU A 1 297 ? -29.273 -13.024 -26.587 1.00 49.27  ? 560  GLU A O   1 
ATOM   2065 C  CB  . GLU A 1 297 ? -32.574 -12.839 -27.431 1.00 55.84  ? 560  GLU A CB  1 
ATOM   2066 C  CG  . GLU A 1 297 ? -32.963 -12.731 -25.979 1.00 60.83  ? 560  GLU A CG  1 
ATOM   2067 C  CD  . GLU A 1 297 ? -34.444 -12.921 -25.725 1.00 68.96  ? 560  GLU A CD  1 
ATOM   2068 O  OE1 . GLU A 1 297 ? -34.868 -14.084 -25.576 1.00 69.14  ? 560  GLU A OE1 1 
ATOM   2069 O  OE2 . GLU A 1 297 ? -35.165 -11.904 -25.672 1.00 76.34  ? 560  GLU A OE2 1 
ATOM   2070 N  N   . HIS A 1 298 ? -30.100 -14.353 -28.237 1.00 47.77  ? 561  HIS A N   1 
ATOM   2071 C  CA  . HIS A 1 298 ? -29.117 -15.459 -28.086 1.00 45.52  ? 561  HIS A CA  1 
ATOM   2072 C  C   . HIS A 1 298 ? -27.720 -14.860 -27.926 1.00 39.99  ? 561  HIS A C   1 
ATOM   2073 O  O   . HIS A 1 298 ? -27.081 -15.164 -26.906 1.00 46.10  ? 561  HIS A O   1 
ATOM   2074 C  CB  . HIS A 1 298 ? -29.195 -16.462 -29.234 1.00 41.39  ? 561  HIS A CB  1 
ATOM   2075 C  CG  . HIS A 1 298 ? -28.308 -17.642 -28.998 1.00 37.90  ? 561  HIS A CG  1 
ATOM   2076 N  ND1 . HIS A 1 298 ? -27.848 -18.447 -30.032 1.00 36.25  ? 561  HIS A ND1 1 
ATOM   2077 C  CD2 . HIS A 1 298 ? -27.767 -18.119 -27.853 1.00 37.58  ? 561  HIS A CD2 1 
ATOM   2078 C  CE1 . HIS A 1 298 ? -27.064 -19.385 -29.521 1.00 38.12  ? 561  HIS A CE1 1 
ATOM   2079 N  NE2 . HIS A 1 298 ? -26.995 -19.203 -28.185 1.00 36.47  ? 561  HIS A NE2 1 
ATOM   2080 N  N   . LYS A 1 299 ? -27.274 -14.020 -28.859 1.00 39.03  ? 562  LYS A N   1 
ATOM   2081 C  CA  . LYS A 1 299 ? -25.908 -13.442 -28.854 1.00 43.12  ? 562  LYS A CA  1 
ATOM   2082 C  C   . LYS A 1 299 ? -25.652 -12.745 -27.521 1.00 51.55  ? 562  LYS A C   1 
ATOM   2083 O  O   . LYS A 1 299 ? -24.524 -12.885 -26.982 1.00 46.73  ? 562  LYS A O   1 
ATOM   2084 C  CB  . LYS A 1 299 ? -25.664 -12.479 -30.017 1.00 44.53  ? 562  LYS A CB  1 
ATOM   2085 C  CG  . LYS A 1 299 ? -24.326 -11.747 -29.982 1.00 43.57  ? 562  LYS A CG  1 
ATOM   2086 C  CD  . LYS A 1 299 ? -24.069 -11.000 -31.263 1.00 47.41  ? 562  LYS A CD  1 
ATOM   2087 C  CE  . LYS A 1 299 ? -22.846 -10.113 -31.279 1.00 47.93  ? 562  LYS A CE  1 
ATOM   2088 N  NZ  . LYS A 1 299 ? -21.768 -10.734 -32.072 1.00 51.65  ? 562  LYS A NZ  1 
ATOM   2089 N  N   . LYS A 1 300 ? -26.642 -12.004 -27.015 1.00 54.21  ? 563  LYS A N   1 
ATOM   2090 C  CA  . LYS A 1 300 ? -26.478 -11.194 -25.780 1.00 54.05  ? 563  LYS A CA  1 
ATOM   2091 C  C   . LYS A 1 300 ? -26.400 -12.128 -24.580 1.00 43.15  ? 563  LYS A C   1 
ATOM   2092 O  O   . LYS A 1 300 ? -25.562 -11.879 -23.720 1.00 44.36  ? 563  LYS A O   1 
ATOM   2093 C  CB  . LYS A 1 300 ? -27.633 -10.198 -25.576 1.00 61.96  ? 563  LYS A CB  1 
ATOM   2094 C  CG  . LYS A 1 300 ? -27.633 -9.024  -26.546 1.00 68.29  ? 563  LYS A CG  1 
ATOM   2095 C  CD  . LYS A 1 300 ? -26.431 -8.113  -26.415 1.00 69.87  ? 563  LYS A CD  1 
ATOM   2096 C  CE  . LYS A 1 300 ? -25.816 -7.729  -27.743 1.00 76.42  ? 563  LYS A CE  1 
ATOM   2097 N  NZ  . LYS A 1 300 ? -24.961 -6.523  -27.614 1.00 81.69  ? 563  LYS A NZ  1 
ATOM   2098 N  N   . LEU A 1 301 ? -27.262 -13.145 -24.539 1.00 42.84  ? 564  LEU A N   1 
ATOM   2099 C  CA  . LEU A 1 301 ? -27.328 -14.120 -23.422 1.00 43.13  ? 564  LEU A CA  1 
ATOM   2100 C  C   . LEU A 1 301 ? -26.012 -14.939 -23.350 1.00 45.59  ? 564  LEU A C   1 
ATOM   2101 O  O   . LEU A 1 301 ? -25.537 -15.203 -22.220 1.00 40.35  ? 564  LEU A O   1 
ATOM   2102 C  CB  . LEU A 1 301 ? -28.549 -15.016 -23.631 1.00 47.25  ? 564  LEU A CB  1 
ATOM   2103 C  CG  . LEU A 1 301 ? -29.913 -14.353 -23.380 1.00 45.29  ? 564  LEU A CG  1 
ATOM   2104 C  CD1 . LEU A 1 301 ? -31.019 -15.294 -23.780 1.00 46.06  ? 564  LEU A CD1 1 
ATOM   2105 C  CD2 . LEU A 1 301 ? -30.061 -13.949 -21.921 1.00 44.34  ? 564  LEU A CD2 1 
ATOM   2106 N  N   . ALA A 1 302 ? -25.438 -15.322 -24.494 1.00 42.64  ? 565  ALA A N   1 
ATOM   2107 C  CA  . ALA A 1 302 ? -24.174 -16.110 -24.560 1.00 42.82  ? 565  ALA A CA  1 
ATOM   2108 C  C   . ALA A 1 302 ? -22.998 -15.218 -24.152 1.00 42.52  ? 565  ALA A C   1 
ATOM   2109 O  O   . ALA A 1 302 ? -22.085 -15.697 -23.421 1.00 39.82  ? 565  ALA A O   1 
ATOM   2110 C  CB  . ALA A 1 302 ? -23.989 -16.702 -25.937 1.00 39.87  ? 565  ALA A CB  1 
ATOM   2111 N  N   . GLU A 1 303 ? -23.002 -13.959 -24.587 1.00 43.48  ? 566  GLU A N   1 
ATOM   2112 C  CA  . GLU A 1 303 ? -21.939 -12.987 -24.215 1.00 43.18  ? 566  GLU A CA  1 
ATOM   2113 C  C   . GLU A 1 303 ? -21.921 -12.816 -22.693 1.00 39.91  ? 566  GLU A C   1 
ATOM   2114 O  O   . GLU A 1 303 ? -20.825 -12.681 -22.146 1.00 40.54  ? 566  GLU A O   1 
ATOM   2115 C  CB  . GLU A 1 303 ? -22.141 -11.654 -24.934 1.00 49.38  ? 566  GLU A CB  1 
ATOM   2116 C  CG  . GLU A 1 303 ? -21.777 -11.726 -26.394 1.00 51.21  ? 566  GLU A CG  1 
ATOM   2117 C  CD  . GLU A 1 303 ? -22.019 -10.436 -27.160 1.00 58.72  ? 566  GLU A CD  1 
ATOM   2118 O  OE1 . GLU A 1 303 ? -22.378 -9.437  -26.523 1.00 66.69  ? 566  GLU A OE1 1 
ATOM   2119 O  OE2 . GLU A 1 303 ? -21.820 -10.436 -28.394 1.00 53.55  ? 566  GLU A OE2 1 
ATOM   2120 N  N   . ALA A 1 304 ? -23.078 -12.836 -22.033 1.00 38.97  ? 567  ALA A N   1 
ATOM   2121 C  CA  . ALA A 1 304 ? -23.173 -12.673 -20.561 1.00 43.44  ? 567  ALA A CA  1 
ATOM   2122 C  C   . ALA A 1 304 ? -22.608 -13.917 -19.860 1.00 40.74  ? 567  ALA A C   1 
ATOM   2123 O  O   . ALA A 1 304 ? -21.891 -13.748 -18.853 1.00 41.05  ? 567  ALA A O   1 
ATOM   2124 C  CB  . ALA A 1 304 ? -24.596 -12.404 -20.120 1.00 44.23  ? 567  ALA A CB  1 
ATOM   2125 N  N   . ILE A 1 305 ? -22.951 -15.118 -20.330 1.00 41.41  ? 568  ILE A N   1 
ATOM   2126 C  CA  . ILE A 1 305 ? -22.415 -16.372 -19.724 1.00 42.48  ? 568  ILE A CA  1 
ATOM   2127 C  C   . ILE A 1 305 ? -20.885 -16.285 -19.760 1.00 36.50  ? 568  ILE A C   1 
ATOM   2128 O  O   . ILE A 1 305 ? -20.269 -16.391 -18.678 1.00 37.60  ? 568  ILE A O   1 
ATOM   2129 C  CB  . ILE A 1 305 ? -22.950 -17.655 -20.400 1.00 44.60  ? 568  ILE A CB  1 
ATOM   2130 C  CG1 . ILE A 1 305 ? -24.446 -17.869 -20.142 1.00 45.29  ? 568  ILE A CG1 1 
ATOM   2131 C  CG2 . ILE A 1 305 ? -22.127 -18.877 -19.964 1.00 43.17  ? 568  ILE A CG2 1 
ATOM   2132 C  CD1 . ILE A 1 305 ? -24.827 -17.925 -18.680 1.00 42.71  ? 568  ILE A CD1 1 
ATOM   2133 N  N   . PHE A 1 306 ? -20.279 -16.011 -20.916 1.00 37.18  ? 569  PHE A N   1 
ATOM   2134 C  CA  . PHE A 1 306 ? -18.800 -15.989 -21.061 1.00 36.77  ? 569  PHE A CA  1 
ATOM   2135 C  C   . PHE A 1 306 ? -18.209 -14.890 -20.169 1.00 46.07  ? 569  PHE A C   1 
ATOM   2136 O  O   . PHE A 1 306 ? -17.274 -15.208 -19.409 1.00 41.45  ? 569  PHE A O   1 
ATOM   2137 C  CB  . PHE A 1 306 ? -18.354 -15.796 -22.509 1.00 41.13  ? 569  PHE A CB  1 
ATOM   2138 C  CG  . PHE A 1 306 ? -18.398 -17.042 -23.358 1.00 39.49  ? 569  PHE A CG  1 
ATOM   2139 C  CD1 . PHE A 1 306 ? -17.410 -18.009 -23.235 1.00 43.00  ? 569  PHE A CD1 1 
ATOM   2140 C  CD2 . PHE A 1 306 ? -19.345 -17.189 -24.358 1.00 37.99  ? 569  PHE A CD2 1 
ATOM   2141 C  CE1 . PHE A 1 306 ? -17.429 -19.140 -24.040 1.00 40.12  ? 569  PHE A CE1 1 
ATOM   2142 C  CE2 . PHE A 1 306 ? -19.362 -18.312 -25.169 1.00 39.07  ? 569  PHE A CE2 1 
ATOM   2143 C  CZ  . PHE A 1 306 ? -18.421 -19.301 -24.983 1.00 39.86  ? 569  PHE A CZ  1 
ATOM   2144 N  N   . LYS A 1 307 ? -18.740 -13.658 -20.245 1.00 45.06  ? 570  LYS A N   1 
ATOM   2145 C  CA  . LYS A 1 307 ? -18.245 -12.460 -19.494 1.00 47.90  ? 570  LYS A CA  1 
ATOM   2146 C  C   . LYS A 1 307 ? -18.417 -12.631 -17.983 1.00 42.08  ? 570  LYS A C   1 
ATOM   2147 O  O   . LYS A 1 307 ? -17.458 -12.395 -17.241 1.00 42.69  ? 570  LYS A O   1 
ATOM   2148 C  CB  . LYS A 1 307 ? -19.024 -11.177 -19.834 1.00 59.50  ? 570  LYS A CB  1 
ATOM   2149 C  CG  . LYS A 1 307 ? -18.324 -10.189 -20.753 1.00 68.53  ? 570  LYS A CG  1 
ATOM   2150 C  CD  . LYS A 1 307 ? -18.811 -8.757  -20.584 1.00 78.44  ? 570  LYS A CD  1 
ATOM   2151 C  CE  . LYS A 1 307 ? -18.189 -7.795  -21.576 1.00 83.16  ? 570  LYS A CE  1 
ATOM   2152 N  NZ  . LYS A 1 307 ? -18.349 -8.266  -22.974 1.00 90.71  ? 570  LYS A NZ  1 
ATOM   2153 N  N   . LEU A 1 308 ? -19.616 -12.977 -17.535 1.00 41.99  ? 571  LEU A N   1 
ATOM   2154 C  CA  . LEU A 1 308 ? -19.999 -12.801 -16.111 1.00 43.06  ? 571  LEU A CA  1 
ATOM   2155 C  C   . LEU A 1 308 ? -19.719 -14.061 -15.307 1.00 44.86  ? 571  LEU A C   1 
ATOM   2156 O  O   . LEU A 1 308 ? -19.473 -13.906 -14.092 1.00 46.53  ? 571  LEU A O   1 
ATOM   2157 C  CB  . LEU A 1 308 ? -21.476 -12.399 -16.043 1.00 46.35  ? 571  LEU A CB  1 
ATOM   2158 C  CG  . LEU A 1 308 ? -21.787 -11.099 -16.793 1.00 48.97  ? 571  LEU A CG  1 
ATOM   2159 C  CD1 . LEU A 1 308 ? -23.284 -10.891 -16.948 1.00 50.43  ? 571  LEU A CD1 1 
ATOM   2160 C  CD2 . LEU A 1 308 ? -21.154 -9.913  -16.094 1.00 49.29  ? 571  LEU A CD2 1 
ATOM   2161 N  N   . THR A 1 309 ? -19.754 -15.251 -15.923 1.00 42.09  ? 572  THR A N   1 
ATOM   2162 C  CA  . THR A 1 309 ? -19.627 -16.534 -15.185 1.00 41.62  ? 572  THR A CA  1 
ATOM   2163 C  C   . THR A 1 309 ? -18.339 -17.282 -15.568 1.00 42.30  ? 572  THR A C   1 
ATOM   2164 O  O   . THR A 1 309 ? -17.853 -17.987 -14.731 1.00 41.43  ? 572  THR A O   1 
ATOM   2165 C  CB  . THR A 1 309 ? -20.880 -17.397 -15.352 1.00 44.68  ? 572  THR A CB  1 
ATOM   2166 O  OG1 . THR A 1 309 ? -20.957 -17.843 -16.706 1.00 43.01  ? 572  THR A OG1 1 
ATOM   2167 C  CG2 . THR A 1 309 ? -22.141 -16.642 -14.998 1.00 49.85  ? 572  THR A CG2 1 
ATOM   2168 N  N   . TYR A 1 310 ? -17.769 -17.114 -16.757 1.00 41.74  ? 573  TYR A N   1 
ATOM   2169 C  CA  . TYR A 1 310 ? -16.594 -17.934 -17.183 1.00 45.92  ? 573  TYR A CA  1 
ATOM   2170 C  C   . TYR A 1 310 ? -15.313 -17.122 -17.026 1.00 45.86  ? 573  TYR A C   1 
ATOM   2171 O  O   . TYR A 1 310 ? -14.335 -17.709 -16.517 1.00 47.45  ? 573  TYR A O   1 
ATOM   2172 C  CB  . TYR A 1 310 ? -16.717 -18.441 -18.628 1.00 40.12  ? 573  TYR A CB  1 
ATOM   2173 C  CG  . TYR A 1 310 ? -17.747 -19.513 -18.887 1.00 35.74  ? 573  TYR A CG  1 
ATOM   2174 C  CD1 . TYR A 1 310 ? -18.593 -19.988 -17.905 1.00 36.45  ? 573  TYR A CD1 1 
ATOM   2175 C  CD2 . TYR A 1 310 ? -17.933 -20.001 -20.171 1.00 36.30  ? 573  TYR A CD2 1 
ATOM   2176 C  CE1 . TYR A 1 310 ? -19.563 -20.943 -18.171 1.00 35.32  ? 573  TYR A CE1 1 
ATOM   2177 C  CE2 . TYR A 1 310 ? -18.906 -20.942 -20.458 1.00 34.97  ? 573  TYR A CE2 1 
ATOM   2178 C  CZ  . TYR A 1 310 ? -19.714 -21.431 -19.456 1.00 34.12  ? 573  TYR A CZ  1 
ATOM   2179 O  OH  . TYR A 1 310 ? -20.679 -22.347 -19.737 1.00 36.11  ? 573  TYR A OH  1 
ATOM   2180 N  N   . GLN A 1 311 ? -15.309 -15.866 -17.503 1.00 40.00  ? 574  GLN A N   1 
ATOM   2181 C  CA  . GLN A 1 311 ? -14.144 -14.949 -17.447 1.00 42.50  ? 574  GLN A CA  1 
ATOM   2182 C  C   . GLN A 1 311 ? -14.058 -14.193 -16.102 1.00 46.58  ? 574  GLN A C   1 
ATOM   2183 O  O   . GLN A 1 311 ? -13.064 -13.497 -15.880 1.00 45.79  ? 574  GLN A O   1 
ATOM   2184 C  CB  . GLN A 1 311 ? -14.166 -14.014 -18.645 1.00 43.19  ? 574  GLN A CB  1 
ATOM   2185 C  CG  . GLN A 1 311 ? -14.086 -14.765 -19.963 1.00 44.44  ? 574  GLN A CG  1 
ATOM   2186 C  CD  . GLN A 1 311 ? -14.179 -13.835 -21.143 1.00 47.16  ? 574  GLN A CD  1 
ATOM   2187 O  OE1 . GLN A 1 311 ? -14.043 -12.627 -21.018 1.00 59.87  ? 574  GLN A OE1 1 
ATOM   2188 N  NE2 . GLN A 1 311 ? -14.367 -14.399 -22.317 1.00 52.74  ? 574  GLN A NE2 1 
ATOM   2189 N  N   . ASN A 1 312 ? -15.039 -14.373 -15.202 0.50 48.72  ? 575  ASN A N   1 
ATOM   2190 C  CA  . ASN A 1 312 ? -15.082 -13.733 -13.854 0.50 49.76  ? 575  ASN A CA  1 
ATOM   2191 C  C   . ASN A 1 312 ? -15.909 -14.589 -12.882 0.50 51.75  ? 575  ASN A C   1 
ATOM   2192 O  O   . ASN A 1 312 ? -17.104 -14.288 -12.716 0.50 56.93  ? 575  ASN A O   1 
ATOM   2193 C  CB  . ASN A 1 312 ? -15.688 -12.326 -13.913 0.50 48.40  ? 575  ASN A CB  1 
ATOM   2194 C  CG  . ASN A 1 312 ? -14.877 -11.350 -14.740 0.50 49.09  ? 575  ASN A CG  1 
ATOM   2195 O  OD1 . ASN A 1 312 ? -13.819 -10.897 -14.313 0.50 48.84  ? 575  ASN A OD1 1 
ATOM   2196 N  ND2 . ASN A 1 312 ? -15.366 -11.014 -15.923 0.50 49.04  ? 575  ASN A ND2 1 
ATOM   2197 N  N   . LYS A 1 313 ? -15.296 -15.578 -12.225 0.50 52.73  ? 576  LYS A N   1 
ATOM   2198 C  CA  . LYS A 1 313 ? -16.007 -16.608 -11.414 0.50 53.59  ? 576  LYS A CA  1 
ATOM   2199 C  C   . LYS A 1 313 ? -16.086 -16.188 -9.939  0.50 54.73  ? 576  LYS A C   1 
ATOM   2200 O  O   . LYS A 1 313 ? -15.193 -15.443 -9.491  0.50 56.21  ? 576  LYS A O   1 
ATOM   2201 C  CB  . LYS A 1 313 ? -15.291 -17.958 -11.499 0.50 55.31  ? 576  LYS A CB  1 
ATOM   2202 C  CG  . LYS A 1 313 ? -14.735 -18.316 -12.868 0.50 57.07  ? 576  LYS A CG  1 
ATOM   2203 C  CD  . LYS A 1 313 ? -13.806 -19.508 -12.834 0.50 57.02  ? 576  LYS A CD  1 
ATOM   2204 C  CE  . LYS A 1 313 ? -12.927 -19.583 -14.060 0.50 58.43  ? 576  LYS A CE  1 
ATOM   2205 N  NZ  . LYS A 1 313 ? -12.423 -18.241 -14.436 0.50 60.38  ? 576  LYS A NZ  1 
ATOM   2206 N  N   . VAL A 1 314 ? -17.118 -16.677 -9.235  1.00 51.50  ? 577  VAL A N   1 
ATOM   2207 C  CA  . VAL A 1 314 ? -17.336 -16.497 -7.775  1.00 52.66  ? 577  VAL A CA  1 
ATOM   2208 C  C   . VAL A 1 314 ? -17.619 -17.892 -7.215  1.00 49.58  ? 577  VAL A C   1 
ATOM   2209 O  O   . VAL A 1 314 ? -18.567 -18.560 -7.683  1.00 43.98  ? 577  VAL A O   1 
ATOM   2210 C  CB  . VAL A 1 314 ? -18.510 -15.538 -7.482  1.00 58.32  ? 577  VAL A CB  1 
ATOM   2211 C  CG1 . VAL A 1 314 ? -18.859 -15.528 -5.997  1.00 59.22  ? 577  VAL A CG1 1 
ATOM   2212 C  CG2 . VAL A 1 314 ? -18.241 -14.130 -7.998  1.00 54.33  ? 577  VAL A CG2 1 
ATOM   2213 N  N   . VAL A 1 315 ? -16.833 -18.334 -6.243  1.00 46.53  ? 578  VAL A N   1 
ATOM   2214 C  CA  . VAL A 1 315 ? -16.886 -19.745 -5.775  1.00 49.69  ? 578  VAL A CA  1 
ATOM   2215 C  C   . VAL A 1 315 ? -16.981 -19.770 -4.256  1.00 48.89  ? 578  VAL A C   1 
ATOM   2216 O  O   . VAL A 1 315 ? -16.332 -18.932 -3.611  1.00 54.07  ? 578  VAL A O   1 
ATOM   2217 C  CB  . VAL A 1 315 ? -15.650 -20.526 -6.255  1.00 52.46  ? 578  VAL A CB  1 
ATOM   2218 C  CG1 . VAL A 1 315 ? -15.752 -21.985 -5.859  1.00 56.28  ? 578  VAL A CG1 1 
ATOM   2219 C  CG2 . VAL A 1 315 ? -15.422 -20.375 -7.751  1.00 57.94  ? 578  VAL A CG2 1 
ATOM   2220 N  N   . ARG A 1 316 ? -17.697 -20.748 -3.725  1.00 55.36  ? 579  ARG A N   1 
ATOM   2221 C  CA  . ARG A 1 316 ? -17.772 -20.996 -2.273  1.00 62.39  ? 579  ARG A CA  1 
ATOM   2222 C  C   . ARG A 1 316 ? -17.176 -22.382 -1.990  1.00 64.31  ? 579  ARG A C   1 
ATOM   2223 O  O   . ARG A 1 316 ? -17.580 -23.350 -2.648  1.00 70.19  ? 579  ARG A O   1 
ATOM   2224 C  CB  . ARG A 1 316 ? -19.202 -20.748 -1.791  1.00 67.31  ? 579  ARG A CB  1 
ATOM   2225 C  CG  . ARG A 1 316 ? -20.242 -21.726 -2.301  1.00 72.65  ? 579  ARG A CG  1 
ATOM   2226 C  CD  . ARG A 1 316 ? -21.552 -21.473 -1.578  1.00 81.29  ? 579  ARG A CD  1 
ATOM   2227 N  NE  . ARG A 1 316 ? -22.261 -20.304 -2.081  1.00 84.16  ? 579  ARG A NE  1 
ATOM   2228 C  CZ  . ARG A 1 316 ? -23.516 -19.992 -1.774  1.00 88.12  ? 579  ARG A CZ  1 
ATOM   2229 N  NH1 . ARG A 1 316 ? -24.071 -18.907 -2.288  1.00 89.80  ? 579  ARG A NH1 1 
ATOM   2230 N  NH2 . ARG A 1 316 ? -24.220 -20.765 -0.963  1.00 88.75  ? 579  ARG A NH2 1 
ATOM   2231 N  N   . VAL A 1 317 ? -16.213 -22.447 -1.065  1.00 64.30  ? 580  VAL A N   1 
ATOM   2232 C  CA  . VAL A 1 317 ? -15.384 -23.648 -0.755  1.00 64.97  ? 580  VAL A CA  1 
ATOM   2233 C  C   . VAL A 1 317 ? -15.479 -23.930 0.747   1.00 70.25  ? 580  VAL A C   1 
ATOM   2234 O  O   . VAL A 1 317 ? -15.408 -22.963 1.523   1.00 63.02  ? 580  VAL A O   1 
ATOM   2235 C  CB  . VAL A 1 317 ? -13.918 -23.424 -1.173  1.00 64.70  ? 580  VAL A CB  1 
ATOM   2236 C  CG1 . VAL A 1 317 ? -13.109 -24.709 -1.095  1.00 65.35  ? 580  VAL A CG1 1 
ATOM   2237 C  CG2 . VAL A 1 317 ? -13.808 -22.812 -2.555  1.00 64.44  ? 580  VAL A CG2 1 
ATOM   2238 N  N   . GLN A 1 318 ? -15.638 -25.204 1.127   1.00 79.16  ? 581  GLN A N   1 
ATOM   2239 C  CA  . GLN A 1 318 ? -15.634 -25.669 2.543   1.00 82.76  ? 581  GLN A CA  1 
ATOM   2240 C  C   . GLN A 1 318 ? -14.190 -25.870 3.001   1.00 84.79  ? 581  GLN A C   1 
ATOM   2241 O  O   . GLN A 1 318 ? -13.494 -26.703 2.381   1.00 76.00  ? 581  GLN A O   1 
ATOM   2242 C  CB  . GLN A 1 318 ? -16.393 -26.984 2.718   1.00 79.74  ? 581  GLN A CB  1 
ATOM   2243 C  CG  . GLN A 1 318 ? -17.894 -26.795 2.858   1.00 83.35  ? 581  GLN A CG  1 
ATOM   2244 C  CD  . GLN A 1 318 ? -18.426 -27.414 4.128   1.00 86.52  ? 581  GLN A CD  1 
ATOM   2245 O  OE1 . GLN A 1 318 ? -17.923 -28.429 4.608   1.00 93.35  ? 581  GLN A OE1 1 
ATOM   2246 N  NE2 . GLN A 1 318 ? -19.453 -26.798 4.692   1.00 88.92  ? 581  GLN A NE2 1 
ATOM   2247 N  N   . ARG A 1 319 ? -13.785 -25.135 4.042   1.00 95.89  ? 582  ARG A N   1 
ATOM   2248 C  CA  . ARG A 1 319 ? -12.476 -25.265 4.737   1.00 100.70 ? 582  ARG A CA  1 
ATOM   2249 C  C   . ARG A 1 319 ? -12.726 -25.741 6.171   1.00 106.38 ? 582  ARG A C   1 
ATOM   2250 O  O   . ARG A 1 319 ? -13.414 -25.046 6.917   1.00 101.07 ? 582  ARG A O   1 
ATOM   2251 C  CB  . ARG A 1 319 ? -11.751 -23.918 4.738   1.00 92.59  ? 582  ARG A CB  1 
ATOM   2252 C  CG  . ARG A 1 319 ? -10.299 -24.013 5.177   1.00 86.33  ? 582  ARG A CG  1 
ATOM   2253 C  CD  . ARG A 1 319 ? -9.471  -22.853 4.668   1.00 84.26  ? 582  ARG A CD  1 
ATOM   2254 N  NE  . ARG A 1 319 ? -10.160 -21.590 4.887   1.00 82.29  ? 582  ARG A NE  1 
ATOM   2255 C  CZ  . ARG A 1 319 ? -9.801  -20.637 5.741   1.00 81.63  ? 582  ARG A CZ  1 
ATOM   2256 N  NH1 . ARG A 1 319 ? -8.722  -20.768 6.498   1.00 88.74  ? 582  ARG A NH1 1 
ATOM   2257 N  NH2 . ARG A 1 319 ? -10.531 -19.540 5.837   1.00 74.12  ? 582  ARG A NH2 1 
ATOM   2258 N  N   . PRO A 1 320 ? -12.184 -26.911 6.592   0.50 110.49 ? 583  PRO A N   1 
ATOM   2259 C  CA  . PRO A 1 320 ? -12.404 -27.432 7.945   0.50 111.58 ? 583  PRO A CA  1 
ATOM   2260 C  C   . PRO A 1 320 ? -12.142 -26.413 9.067   0.50 112.08 ? 583  PRO A C   1 
ATOM   2261 O  O   . PRO A 1 320 ? -13.029 -26.196 9.876   0.50 114.45 ? 583  PRO A O   1 
ATOM   2262 C  CB  . PRO A 1 320 ? -11.399 -28.591 8.049   0.50 110.92 ? 583  PRO A CB  1 
ATOM   2263 C  CG  . PRO A 1 320 ? -11.217 -29.060 6.622   0.50 110.40 ? 583  PRO A CG  1 
ATOM   2264 C  CD  . PRO A 1 320 ? -11.341 -27.806 5.781   0.50 111.32 ? 583  PRO A CD  1 
ATOM   2265 N  N   . THR A 1 321 ? -10.944 -25.820 9.086   0.50 110.33 ? 584  THR A N   1 
ATOM   2266 C  CA  . THR A 1 321 ? -10.507 -24.808 10.086  0.50 107.73 ? 584  THR A CA  1 
ATOM   2267 C  C   . THR A 1 321 ? -11.737 -24.240 10.806  0.50 103.98 ? 584  THR A C   1 
ATOM   2268 O  O   . THR A 1 321 ? -11.602 -23.931 12.006  0.50 99.78  ? 584  THR A O   1 
ATOM   2269 C  CB  . THR A 1 321 ? -9.692  -23.694 9.417   0.50 109.13 ? 584  THR A CB  1 
ATOM   2270 O  OG1 . THR A 1 321 ? -10.572 -22.964 8.561   0.50 109.94 ? 584  THR A OG1 1 
ATOM   2271 C  CG2 . THR A 1 321 ? -8.515  -24.218 8.622   0.50 108.99 ? 584  THR A CG2 1 
ATOM   2272 N  N   . THR A 1 325 ? -15.802 -25.541 10.543  0.50 97.94  ? 588  THR A N   1 
ATOM   2273 C  CA  . THR A 1 325 ? -16.229 -25.458 9.122   0.50 97.50  ? 588  THR A CA  1 
ATOM   2274 C  C   . THR A 1 325 ? -16.585 -24.012 8.772   0.50 97.10  ? 588  THR A C   1 
ATOM   2275 O  O   . THR A 1 325 ? -17.500 -23.458 9.411   0.50 98.25  ? 588  THR A O   1 
ATOM   2276 C  CB  . THR A 1 325 ? -17.413 -26.387 8.844   0.50 98.83  ? 588  THR A CB  1 
ATOM   2277 O  OG1 . THR A 1 325 ? -16.963 -27.731 9.010   0.50 95.50  ? 588  THR A OG1 1 
ATOM   2278 C  CG2 . THR A 1 325 ? -17.982 -26.211 7.453   0.50 99.82  ? 588  THR A CG2 1 
ATOM   2279 N  N   . VAL A 1 326 ? -15.884 -23.429 7.798   0.50 95.62  ? 589  VAL A N   1 
ATOM   2280 C  CA  . VAL A 1 326 ? -16.191 -22.039 7.348   0.50 92.67  ? 589  VAL A CA  1 
ATOM   2281 C  C   . VAL A 1 326 ? -16.409 -22.066 5.832   0.50 90.04  ? 589  VAL A C   1 
ATOM   2282 O  O   . VAL A 1 326 ? -15.894 -22.997 5.183   0.50 87.14  ? 589  VAL A O   1 
ATOM   2283 C  CB  . VAL A 1 326 ? -15.068 -21.061 7.732   0.50 90.91  ? 589  VAL A CB  1 
ATOM   2284 C  CG1 . VAL A 1 326 ? -14.906 -20.957 9.240   0.50 92.01  ? 589  VAL A CG1 1 
ATOM   2285 C  CG2 . VAL A 1 326 ? -13.748 -21.436 7.077   0.50 91.64  ? 589  VAL A CG2 1 
ATOM   2286 N  N   . MET A 1 327 ? -17.156 -21.096 5.298   0.50 85.91  ? 590  MET A N   1 
ATOM   2287 C  CA  . MET A 1 327 ? -17.349 -21.014 3.826   0.50 82.28  ? 590  MET A CA  1 
ATOM   2288 C  C   . MET A 1 327 ? -16.443 -19.916 3.280   0.50 75.36  ? 590  MET A C   1 
ATOM   2289 O  O   . MET A 1 327 ? -16.574 -18.771 3.732   0.50 71.59  ? 590  MET A O   1 
ATOM   2290 C  CB  . MET A 1 327 ? -18.799 -20.693 3.457   0.50 83.16  ? 590  MET A CB  1 
ATOM   2291 C  CG  . MET A 1 327 ? -19.089 -20.880 1.982   0.50 82.50  ? 590  MET A CG  1 
ATOM   2292 S  SD  . MET A 1 327 ? -18.824 -22.586 1.442   0.50 82.38  ? 590  MET A SD  1 
ATOM   2293 C  CE  . MET A 1 327 ? -20.083 -23.434 2.394   0.50 81.30  ? 590  MET A CE  1 
ATOM   2294 N  N   . ASP A 1 328 ? -15.571 -20.271 2.338   0.50 72.74  ? 591  ASP A N   1 
ATOM   2295 C  CA  . ASP A 1 328 ? -14.635 -19.281 1.752   0.50 70.77  ? 591  ASP A CA  1 
ATOM   2296 C  C   . ASP A 1 328 ? -15.186 -18.775 0.416   0.50 68.34  ? 591  ASP A C   1 
ATOM   2297 O  O   . ASP A 1 328 ? -15.269 -19.578 -0.527  0.50 68.73  ? 591  ASP A O   1 
ATOM   2298 C  CB  . ASP A 1 328 ? -13.222 -19.850 1.610   0.50 71.92  ? 591  ASP A CB  1 
ATOM   2299 C  CG  . ASP A 1 328 ? -12.633 -20.361 2.913   0.50 73.37  ? 591  ASP A CG  1 
ATOM   2300 O  OD1 . ASP A 1 328 ? -11.422 -20.637 2.930   0.50 77.02  ? 591  ASP A OD1 1 
ATOM   2301 O  OD2 . ASP A 1 328 ? -13.392 -20.489 3.893   0.50 67.88  ? 591  ASP A OD2 1 
ATOM   2302 N  N   . ILE A 1 329 ? -15.578 -17.508 0.362   0.50 64.10  ? 592  ILE A N   1 
ATOM   2303 C  CA  . ILE A 1 329 ? -16.038 -16.863 -0.902  0.50 62.44  ? 592  ILE A CA  1 
ATOM   2304 C  C   . ILE A 1 329 ? -14.810 -16.316 -1.630  0.50 63.40  ? 592  ILE A C   1 
ATOM   2305 O  O   . ILE A 1 329 ? -14.310 -15.248 -1.228  0.50 63.58  ? 592  ILE A O   1 
ATOM   2306 C  CB  . ILE A 1 329 ? -17.076 -15.759 -0.626  0.50 62.98  ? 592  ILE A CB  1 
ATOM   2307 C  CG1 . ILE A 1 329 ? -18.350 -16.329 0.004   0.50 63.03  ? 592  ILE A CG1 1 
ATOM   2308 C  CG2 . ILE A 1 329 ? -17.373 -14.971 -1.894  0.50 62.72  ? 592  ILE A CG2 1 
ATOM   2309 C  CD1 . ILE A 1 329 ? -18.926 -17.511 -0.739  0.50 62.69  ? 592  ILE A CD1 1 
ATOM   2310 N  N   . ILE A 1 330 ? -14.355 -17.033 -2.661  0.50 63.74  ? 593  ILE A N   1 
ATOM   2311 C  CA  . ILE A 1 330 ? -13.137 -16.700 -3.457  0.50 62.24  ? 593  ILE A CA  1 
ATOM   2312 C  C   . ILE A 1 330 ? -13.548 -16.480 -4.915  0.50 58.95  ? 593  ILE A C   1 
ATOM   2313 O  O   . ILE A 1 330 ? -14.602 -17.002 -5.312  0.50 57.20  ? 593  ILE A O   1 
ATOM   2314 C  CB  . ILE A 1 330 ? -12.089 -17.821 -3.318  0.50 64.70  ? 593  ILE A CB  1 
ATOM   2315 C  CG1 . ILE A 1 330 ? -12.705 -19.201 -3.572  0.50 63.70  ? 593  ILE A CG1 1 
ATOM   2316 C  CG2 . ILE A 1 330 ? -11.409 -17.748 -1.959  0.50 65.06  ? 593  ILE A CG2 1 
ATOM   2317 C  CD1 . ILE A 1 330 ? -11.694 -20.283 -3.888  0.50 63.85  ? 593  ILE A CD1 1 
ATOM   2318 N  N   . SER A 1 331 ? -12.735 -15.738 -5.671  0.50 57.27  ? 594  SER A N   1 
ATOM   2319 C  CA  . SER A 1 331 ? -12.952 -15.426 -7.106  0.50 55.67  ? 594  SER A CA  1 
ATOM   2320 C  C   . SER A 1 331 ? -11.663 -15.685 -7.893  0.50 54.38  ? 594  SER A C   1 
ATOM   2321 O  O   . SER A 1 331 ? -10.605 -15.854 -7.258  0.50 52.82  ? 594  SER A O   1 
ATOM   2322 C  CB  . SER A 1 331 ? -13.418 -14.007 -7.279  0.50 55.89  ? 594  SER A CB  1 
ATOM   2323 O  OG  . SER A 1 331 ? -12.331 -13.104 -7.149  0.50 56.92  ? 594  SER A OG  1 
ATOM   2324 N  N   . ARG A 1 332 ? -11.767 -15.723 -9.225  0.50 51.06  ? 595  ARG A N   1 
ATOM   2325 C  CA  . ARG A 1 332 ? -10.622 -15.725 -10.172 0.50 48.96  ? 595  ARG A CA  1 
ATOM   2326 C  C   . ARG A 1 332 ? -11.178 -15.645 -11.591 0.50 47.99  ? 595  ARG A C   1 
ATOM   2327 O  O   . ARG A 1 332 ? -12.365 -15.981 -11.776 0.50 48.90  ? 595  ARG A O   1 
ATOM   2328 C  CB  . ARG A 1 332 ? -9.758  -16.978 -10.009 0.50 49.34  ? 595  ARG A CB  1 
ATOM   2329 C  CG  . ARG A 1 332 ? -10.254 -18.172 -10.809 0.50 49.48  ? 595  ARG A CG  1 
ATOM   2330 C  CD  . ARG A 1 332 ? -9.252  -19.309 -10.818 0.50 49.64  ? 595  ARG A CD  1 
ATOM   2331 N  NE  . ARG A 1 332 ? -7.961  -18.909 -11.358 0.50 48.28  ? 595  ARG A NE  1 
ATOM   2332 C  CZ  . ARG A 1 332 ? -6.796  -19.137 -10.765 0.50 47.39  ? 595  ARG A CZ  1 
ATOM   2333 N  NH1 . ARG A 1 332 ? -6.754  -19.778 -9.609  0.50 47.01  ? 595  ARG A NH1 1 
ATOM   2334 N  NH2 . ARG A 1 332 ? -5.676  -18.743 -11.341 0.50 47.44  ? 595  ARG A NH2 1 
ATOM   2335 N  N   . ARG A 1 333 ? -10.348 -15.223 -12.544 0.50 45.66  ? 596  ARG A N   1 
ATOM   2336 C  CA  . ARG A 1 333 ? -10.767 -14.958 -13.943 0.50 48.64  ? 596  ARG A CA  1 
ATOM   2337 C  C   . ARG A 1 333 ? -10.509 -16.203 -14.804 0.50 44.73  ? 596  ARG A C   1 
ATOM   2338 O  O   . ARG A 1 333 ? -11.407 -16.570 -15.581 0.50 42.52  ? 596  ARG A O   1 
ATOM   2339 C  CB  . ARG A 1 333 ? -10.042 -13.715 -14.471 0.50 51.04  ? 596  ARG A CB  1 
ATOM   2340 C  CG  . ARG A 1 333 ? -10.429 -12.428 -13.751 0.50 56.24  ? 596  ARG A CG  1 
ATOM   2341 C  CD  . ARG A 1 333 ? -10.293 -11.198 -14.635 0.50 59.90  ? 596  ARG A CD  1 
ATOM   2342 N  NE  . ARG A 1 333 ? -11.105 -11.303 -15.843 0.50 63.26  ? 596  ARG A NE  1 
ATOM   2343 C  CZ  . ARG A 1 333 ? -10.869 -10.640 -16.972 0.50 65.98  ? 596  ARG A CZ  1 
ATOM   2344 N  NH1 . ARG A 1 333 ? -9.836  -9.818  -17.055 0.50 66.59  ? 596  ARG A NH1 1 
ATOM   2345 N  NH2 . ARG A 1 333 ? -11.661 -10.810 -18.017 0.50 66.11  ? 596  ARG A NH2 1 
ATOM   2346 N  N   . ASP A 1 334 ? -9.335  -16.822 -14.653 0.50 43.79  ? 597  ASP A N   1 
ATOM   2347 C  CA  . ASP A 1 334 ? -8.815  -17.896 -15.544 0.50 43.32  ? 597  ASP A CA  1 
ATOM   2348 C  C   . ASP A 1 334 ? -9.297  -19.272 -15.061 0.50 40.79  ? 597  ASP A C   1 
ATOM   2349 O  O   . ASP A 1 334 ? -10.079 -19.327 -14.090 0.50 40.01  ? 597  ASP A O   1 
ATOM   2350 C  CB  . ASP A 1 334 ? -7.286  -17.830 -15.626 0.50 44.90  ? 597  ASP A CB  1 
ATOM   2351 C  CG  . ASP A 1 334 ? -6.568  -18.272 -14.360 0.50 46.51  ? 597  ASP A CG  1 
ATOM   2352 O  OD1 . ASP A 1 334 ? -7.239  -18.394 -13.314 0.50 49.16  ? 597  ASP A OD1 1 
ATOM   2353 O  OD2 . ASP A 1 334 ? -5.340  -18.496 -14.432 0.50 49.32  ? 597  ASP A OD2 1 
ATOM   2354 N  N   . GLN A 1 335 ? -8.851  -20.337 -15.741 1.00 39.91  ? 598  GLN A N   1 
ATOM   2355 C  CA  . GLN A 1 335 ? -9.169  -21.757 -15.425 1.00 37.66  ? 598  GLN A CA  1 
ATOM   2356 C  C   . GLN A 1 335 ? -10.560 -22.101 -15.960 1.00 39.44  ? 598  GLN A C   1 
ATOM   2357 O  O   . GLN A 1 335 ? -11.392 -21.194 -16.191 1.00 38.43  ? 598  GLN A O   1 
ATOM   2358 C  CB  . GLN A 1 335 ? -9.100  -22.153 -13.948 1.00 38.99  ? 598  GLN A CB  1 
ATOM   2359 C  CG  . GLN A 1 335 ? -7.720  -21.923 -13.364 1.00 42.55  ? 598  GLN A CG  1 
ATOM   2360 C  CD  . GLN A 1 335 ? -7.488  -22.642 -12.059 1.00 46.01  ? 598  GLN A CD  1 
ATOM   2361 O  OE1 . GLN A 1 335 ? -8.382  -23.266 -11.498 1.00 54.06  ? 598  GLN A OE1 1 
ATOM   2362 N  NE2 . GLN A 1 335 ? -6.253  -22.572 -11.592 1.00 47.25  ? 598  GLN A NE2 1 
ATOM   2363 N  N   . ARG A 1 336 ? -10.771 -23.392 -16.176 1.00 39.88  ? 599  ARG A N   1 
ATOM   2364 C  CA  . ARG A 1 336 ? -12.084 -23.948 -16.564 1.00 40.64  ? 599  ARG A CA  1 
ATOM   2365 C  C   . ARG A 1 336 ? -12.933 -24.133 -15.310 1.00 42.82  ? 599  ARG A C   1 
ATOM   2366 O  O   . ARG A 1 336 ? -12.518 -24.834 -14.382 1.00 45.79  ? 599  ARG A O   1 
ATOM   2367 C  CB  . ARG A 1 336 ? -11.955 -25.278 -17.306 1.00 37.40  ? 599  ARG A CB  1 
ATOM   2368 C  CG  . ARG A 1 336 ? -13.295 -25.906 -17.660 1.00 35.21  ? 599  ARG A CG  1 
ATOM   2369 C  CD  . ARG A 1 336 ? -13.897 -25.207 -18.873 1.00 35.37  ? 599  ARG A CD  1 
ATOM   2370 N  NE  . ARG A 1 336 ? -13.108 -25.466 -20.060 1.00 30.93  ? 599  ARG A NE  1 
ATOM   2371 C  CZ  . ARG A 1 336 ? -12.856 -24.588 -21.009 1.00 31.07  ? 599  ARG A CZ  1 
ATOM   2372 N  NH1 . ARG A 1 336 ? -13.333 -23.350 -20.903 1.00 29.99  ? 599  ARG A NH1 1 
ATOM   2373 N  NH2 . ARG A 1 336 ? -12.149 -24.956 -22.065 1.00 29.06  ? 599  ARG A NH2 1 
ATOM   2374 N  N   . GLY A 1 337 ? -14.101 -23.505 -15.328 1.00 51.47  ? 600  GLY A N   1 
ATOM   2375 C  CA  . GLY A 1 337 ? -15.191 -23.646 -14.349 1.00 56.93  ? 600  GLY A CA  1 
ATOM   2376 C  C   . GLY A 1 337 ? -16.495 -23.375 -15.069 1.00 61.01  ? 600  GLY A C   1 
ATOM   2377 O  O   . GLY A 1 337 ? -16.899 -22.194 -15.207 1.00 76.39  ? 600  GLY A O   1 
ATOM   2378 N  N   . SER A 1 338 ? -17.117 -24.446 -15.569 0.50 60.91  ? 601  SER A N   1 
ATOM   2379 C  CA  . SER A 1 338 ? -18.421 -24.450 -16.280 0.50 57.00  ? 601  SER A CA  1 
ATOM   2380 C  C   . SER A 1 338 ? -19.165 -25.733 -15.904 0.50 54.97  ? 601  SER A C   1 
ATOM   2381 O  O   . SER A 1 338 ? -18.596 -26.529 -15.134 0.50 54.06  ? 601  SER A O   1 
ATOM   2382 C  CB  . SER A 1 338 ? -18.230 -24.349 -17.773 0.50 57.99  ? 601  SER A CB  1 
ATOM   2383 O  OG  . SER A 1 338 ? -17.117 -23.529 -18.092 0.50 61.47  ? 601  SER A OG  1 
ATOM   2384 N  N   . GLY A 1 339 ? -20.378 -25.926 -16.431 1.00 53.95  ? 602  GLY A N   1 
ATOM   2385 C  CA  . GLY A 1 339 ? -21.078 -27.223 -16.333 1.00 51.26  ? 602  GLY A CA  1 
ATOM   2386 C  C   . GLY A 1 339 ? -20.255 -28.273 -17.069 1.00 46.85  ? 602  GLY A C   1 
ATOM   2387 O  O   . GLY A 1 339 ? -19.490 -27.866 -17.958 1.00 36.52  ? 602  GLY A O   1 
ATOM   2388 N  N   . GLN A 1 340 ? -20.378 -29.553 -16.709 1.00 42.78  ? 603  GLN A N   1 
ATOM   2389 C  CA  . GLN A 1 340 ? -19.513 -30.630 -17.249 1.00 47.39  ? 603  GLN A CA  1 
ATOM   2390 C  C   . GLN A 1 340 ? -19.713 -30.760 -18.770 1.00 44.52  ? 603  GLN A C   1 
ATOM   2391 O  O   . GLN A 1 340 ? -18.721 -31.001 -19.469 1.00 38.85  ? 603  GLN A O   1 
ATOM   2392 C  CB  . GLN A 1 340 ? -19.731 -31.942 -16.490 1.00 57.95  ? 603  GLN A CB  1 
ATOM   2393 C  CG  . GLN A 1 340 ? -21.178 -32.238 -16.122 1.00 72.22  ? 603  GLN A CG  1 
ATOM   2394 C  CD  . GLN A 1 340 ? -21.392 -33.714 -15.882 1.00 82.32  ? 603  GLN A CD  1 
ATOM   2395 O  OE1 . GLN A 1 340 ? -20.479 -34.451 -15.509 1.00 87.24  ? 603  GLN A OE1 1 
ATOM   2396 N  NE2 . GLN A 1 340 ? -22.625 -34.155 -16.079 1.00 85.51  ? 603  GLN A NE2 1 
ATOM   2397 N  N   . VAL A 1 341 ? -20.929 -30.580 -19.289 1.00 41.27  ? 604  VAL A N   1 
ATOM   2398 C  CA  . VAL A 1 341 ? -21.211 -30.784 -20.743 1.00 39.50  ? 604  VAL A CA  1 
ATOM   2399 C  C   . VAL A 1 341 ? -20.627 -29.630 -21.570 1.00 35.58  ? 604  VAL A C   1 
ATOM   2400 O  O   . VAL A 1 341 ? -19.995 -29.902 -22.650 1.00 31.26  ? 604  VAL A O   1 
ATOM   2401 C  CB  . VAL A 1 341 ? -22.719 -30.948 -21.000 1.00 39.73  ? 604  VAL A CB  1 
ATOM   2402 C  CG1 . VAL A 1 341 ? -22.990 -30.995 -22.501 1.00 47.50  ? 604  VAL A CG1 1 
ATOM   2403 C  CG2 . VAL A 1 341 ? -23.283 -32.187 -20.300 1.00 45.47  ? 604  VAL A CG2 1 
ATOM   2404 N  N   . VAL A 1 342 ? -20.854 -28.369 -21.160 1.00 33.38  ? 605  VAL A N   1 
ATOM   2405 C  CA  . VAL A 1 342 ? -20.142 -27.238 -21.831 1.00 32.93  ? 605  VAL A CA  1 
ATOM   2406 C  C   . VAL A 1 342 ? -18.616 -27.379 -21.665 1.00 29.95  ? 605  VAL A C   1 
ATOM   2407 O  O   . VAL A 1 342 ? -17.863 -27.121 -22.638 1.00 28.07  ? 605  VAL A O   1 
ATOM   2408 C  CB  . VAL A 1 342 ? -20.674 -25.883 -21.340 1.00 36.05  ? 605  VAL A CB  1 
ATOM   2409 C  CG1 . VAL A 1 342 ? -19.910 -24.719 -21.955 1.00 33.87  ? 605  VAL A CG1 1 
ATOM   2410 C  CG2 . VAL A 1 342 ? -22.159 -25.749 -21.658 1.00 36.01  ? 605  VAL A CG2 1 
ATOM   2411 N  N   . THR A 1 343 ? -18.125 -27.725 -20.479 1.00 27.62  ? 606  THR A N   1 
ATOM   2412 C  CA  . THR A 1 343 ? -16.671 -27.994 -20.276 1.00 29.57  ? 606  THR A CA  1 
ATOM   2413 C  C   . THR A 1 343 ? -16.161 -28.981 -21.337 1.00 25.74  ? 606  THR A C   1 
ATOM   2414 O  O   . THR A 1 343 ? -15.105 -28.723 -21.892 1.00 26.08  ? 606  THR A O   1 
ATOM   2415 C  CB  . THR A 1 343 ? -16.389 -28.565 -18.884 1.00 31.30  ? 606  THR A CB  1 
ATOM   2416 O  OG1 . THR A 1 343 ? -16.696 -27.519 -17.972 1.00 35.12  ? 606  THR A OG1 1 
ATOM   2417 C  CG2 . THR A 1 343 ? -14.963 -29.043 -18.708 1.00 33.54  ? 606  THR A CG2 1 
ATOM   2418 N  N   . TYR A 1 344 ? -16.889 -30.066 -21.609 1.00 26.03  ? 607  TYR A N   1 
ATOM   2419 C  CA  . TYR A 1 344 ? -16.444 -31.088 -22.579 1.00 26.37  ? 607  TYR A CA  1 
ATOM   2420 C  C   . TYR A 1 344 ? -16.275 -30.430 -23.954 1.00 26.11  ? 607  TYR A C   1 
ATOM   2421 O  O   . TYR A 1 344 ? -15.205 -30.629 -24.590 1.00 22.97  ? 607  TYR A O   1 
ATOM   2422 C  CB  . TYR A 1 344 ? -17.402 -32.278 -22.627 1.00 27.95  ? 607  TYR A CB  1 
ATOM   2423 C  CG  . TYR A 1 344 ? -17.042 -33.292 -23.680 1.00 25.29  ? 607  TYR A CG  1 
ATOM   2424 C  CD1 . TYR A 1 344 ? -16.059 -34.236 -23.426 1.00 26.58  ? 607  TYR A CD1 1 
ATOM   2425 C  CD2 . TYR A 1 344 ? -17.593 -33.252 -24.949 1.00 26.95  ? 607  TYR A CD2 1 
ATOM   2426 C  CE1 . TYR A 1 344 ? -15.692 -35.164 -24.382 1.00 27.25  ? 607  TYR A CE1 1 
ATOM   2427 C  CE2 . TYR A 1 344 ? -17.237 -34.178 -25.918 1.00 29.54  ? 607  TYR A CE2 1 
ATOM   2428 C  CZ  . TYR A 1 344 ? -16.284 -35.141 -25.631 1.00 29.24  ? 607  TYR A CZ  1 
ATOM   2429 O  OH  . TYR A 1 344 ? -15.883 -36.033 -26.592 1.00 31.97  ? 607  TYR A OH  1 
ATOM   2430 N  N   . GLY A 1 345 ? -17.272 -29.669 -24.430 1.00 23.16  ? 608  GLY A N   1 
ATOM   2431 C  CA  . GLY A 1 345 ? -17.219 -29.119 -25.806 1.00 23.36  ? 608  GLY A CA  1 
ATOM   2432 C  C   . GLY A 1 345 ? -16.142 -28.046 -25.930 1.00 22.02  ? 608  GLY A C   1 
ATOM   2433 O  O   . GLY A 1 345 ? -15.376 -28.076 -26.889 1.00 26.46  ? 608  GLY A O   1 
ATOM   2434 N  N   . LEU A 1 346 ? -15.989 -27.181 -24.940 1.00 22.66  ? 609  LEU A N   1 
ATOM   2435 C  CA  . LEU A 1 346 ? -14.969 -26.125 -25.024 1.00 25.25  ? 609  LEU A CA  1 
ATOM   2436 C  C   . LEU A 1 346 ? -13.543 -26.704 -24.838 1.00 22.96  ? 609  LEU A C   1 
ATOM   2437 O  O   . LEU A 1 346 ? -12.625 -26.166 -25.458 1.00 23.71  ? 609  LEU A O   1 
ATOM   2438 C  CB  . LEU A 1 346 ? -15.310 -25.062 -23.986 1.00 26.03  ? 609  LEU A CB  1 
ATOM   2439 C  CG  . LEU A 1 346 ? -16.585 -24.269 -24.244 1.00 26.60  ? 609  LEU A CG  1 
ATOM   2440 C  CD1 . LEU A 1 346 ? -16.727 -23.179 -23.198 1.00 32.06  ? 609  LEU A CD1 1 
ATOM   2441 C  CD2 . LEU A 1 346 ? -16.583 -23.689 -25.652 1.00 27.52  ? 609  LEU A CD2 1 
ATOM   2442 N  N   . ASN A 1 347 ? -13.358 -27.701 -23.976 1.00 23.90  ? 610  ASN A N   1 
ATOM   2443 C  CA  . ASN A 1 347 ? -12.080 -28.454 -23.876 1.00 23.04  ? 610  ASN A CA  1 
ATOM   2444 C  C   . ASN A 1 347 ? -11.783 -29.064 -25.240 1.00 22.27  ? 610  ASN A C   1 
ATOM   2445 O  O   . ASN A 1 347 ? -10.635 -28.966 -25.678 1.00 22.47  ? 610  ASN A O   1 
ATOM   2446 C  CB  . ASN A 1 347 ? -12.105 -29.505 -22.756 1.00 23.38  ? 610  ASN A CB  1 
ATOM   2447 C  CG  . ASN A 1 347 ? -11.946 -28.908 -21.376 1.00 27.58  ? 610  ASN A CG  1 
ATOM   2448 O  OD1 . ASN A 1 347 ? -11.600 -27.737 -21.204 1.00 26.86  ? 610  ASN A OD1 1 
ATOM   2449 N  ND2 . ASN A 1 347 ? -12.122 -29.740 -20.371 1.00 27.76  ? 610  ASN A ND2 1 
ATOM   2450 N  N   . THR A 1 348 ? -12.758 -29.696 -25.908 1.00 21.62  ? 611  THR A N   1 
ATOM   2451 C  CA  . THR A 1 348 ? -12.525 -30.300 -27.238 1.00 21.35  ? 611  THR A CA  1 
ATOM   2452 C  C   . THR A 1 348 ? -12.076 -29.196 -28.210 1.00 23.85  ? 611  THR A C   1 
ATOM   2453 O  O   . THR A 1 348 ? -11.095 -29.394 -28.952 1.00 22.11  ? 611  THR A O   1 
ATOM   2454 C  CB  . THR A 1 348 ? -13.738 -31.067 -27.750 1.00 22.13  ? 611  THR A CB  1 
ATOM   2455 O  OG1 . THR A 1 348 ? -14.142 -32.056 -26.796 1.00 21.44  ? 611  THR A OG1 1 
ATOM   2456 C  CG2 . THR A 1 348 ? -13.440 -31.703 -29.072 1.00 21.13  ? 611  THR A CG2 1 
ATOM   2457 N  N   . PHE A 1 349 ? -12.772 -28.051 -28.217 1.00 23.31  ? 612  PHE A N   1 
ATOM   2458 C  CA  . PHE A 1 349 ? -12.453 -26.920 -29.126 1.00 23.26  ? 612  PHE A CA  1 
ATOM   2459 C  C   . PHE A 1 349 ? -11.000 -26.465 -28.928 1.00 22.13  ? 612  PHE A C   1 
ATOM   2460 O  O   . PHE A 1 349 ? -10.224 -26.367 -29.927 1.00 23.91  ? 612  PHE A O   1 
ATOM   2461 C  CB  . PHE A 1 349 ? -13.407 -25.761 -28.837 1.00 24.01  ? 612  PHE A CB  1 
ATOM   2462 C  CG  . PHE A 1 349 ? -13.129 -24.597 -29.733 1.00 24.10  ? 612  PHE A CG  1 
ATOM   2463 C  CD1 . PHE A 1 349 ? -13.648 -24.559 -31.011 1.00 26.63  ? 612  PHE A CD1 1 
ATOM   2464 C  CD2 . PHE A 1 349 ? -12.323 -23.557 -29.290 1.00 24.75  ? 612  PHE A CD2 1 
ATOM   2465 C  CE1 . PHE A 1 349 ? -13.351 -23.492 -31.851 1.00 26.96  ? 612  PHE A CE1 1 
ATOM   2466 C  CE2 . PHE A 1 349 ? -12.011 -22.503 -30.141 1.00 27.52  ? 612  PHE A CE2 1 
ATOM   2467 C  CZ  . PHE A 1 349 ? -12.525 -22.473 -31.412 1.00 28.93  ? 612  PHE A CZ  1 
ATOM   2468 N  N   . THR A 1 350 ? -10.643 -26.198 -27.675 1.00 21.30  ? 613  THR A N   1 
ATOM   2469 C  CA  . THR A 1 350 ? -9.338  -25.582 -27.342 1.00 26.20  ? 613  THR A CA  1 
ATOM   2470 C  C   . THR A 1 350 ? -8.221  -26.621 -27.546 1.00 25.40  ? 613  THR A C   1 
ATOM   2471 O  O   . THR A 1 350 ? -7.144  -26.239 -28.012 1.00 23.70  ? 613  THR A O   1 
ATOM   2472 C  CB  . THR A 1 350 ? -9.368  -24.926 -25.964 1.00 26.71  ? 613  THR A CB  1 
ATOM   2473 O  OG1 . THR A 1 350 ? -10.281 -23.829 -26.037 1.00 28.01  ? 613  THR A OG1 1 
ATOM   2474 C  CG2 . THR A 1 350 ? -8.005  -24.423 -25.546 1.00 27.75  ? 613  THR A CG2 1 
ATOM   2475 N  N   . ASN A 1 351 ? -8.516  -27.908 -27.361 1.00 23.43  ? 614  ASN A N   1 
ATOM   2476 C  CA  . ASN A 1 351 ? -7.525  -28.983 -27.622 1.00 23.85  ? 614  ASN A CA  1 
ATOM   2477 C  C   . ASN A 1 351 ? -7.334  -29.117 -29.140 1.00 23.08  ? 614  ASN A C   1 
ATOM   2478 O  O   . ASN A 1 351 ? -6.179  -29.220 -29.610 1.00 23.73  ? 614  ASN A O   1 
ATOM   2479 C  CB  . ASN A 1 351 ? -7.943  -30.252 -26.869 1.00 22.41  ? 614  ASN A CB  1 
ATOM   2480 C  CG  . ASN A 1 351 ? -6.777  -31.186 -26.607 1.00 26.32  ? 614  ASN A CG  1 
ATOM   2481 O  OD1 . ASN A 1 351 ? -5.619  -30.846 -26.881 1.00 25.29  ? 614  ASN A OD1 1 
ATOM   2482 N  ND2 . ASN A 1 351 ? -7.084  -32.338 -26.033 1.00 25.47  ? 614  ASN A ND2 1 
ATOM   2483 N  N   . MET A 1 352 ? -8.417  -29.058 -29.928 1.00 20.07  ? 615  MET A N   1 
ATOM   2484 C  CA  . MET A 1 352 ? -8.277  -29.112 -31.394 1.00 21.98  ? 615  MET A CA  1 
ATOM   2485 C  C   . MET A 1 352 ? -7.373  -27.950 -31.827 1.00 23.78  ? 615  MET A C   1 
ATOM   2486 O  O   . MET A 1 352 ? -6.459  -28.158 -32.686 1.00 23.89  ? 615  MET A O   1 
ATOM   2487 C  CB  . MET A 1 352 ? -9.633  -28.997 -32.113 1.00 23.05  ? 615  MET A CB  1 
ATOM   2488 C  CG  . MET A 1 352 ? -10.450 -30.215 -31.948 1.00 22.70  ? 615  MET A CG  1 
ATOM   2489 S  SD  . MET A 1 352 ? -12.179 -29.984 -32.586 1.00 28.76  ? 615  MET A SD  1 
ATOM   2490 C  CE  . MET A 1 352 ? -11.911 -29.728 -34.318 1.00 27.64  ? 615  MET A CE  1 
ATOM   2491 N  N   . GLU A 1 353 ? -7.604  -26.783 -31.263 1.00 23.97  ? 616  GLU A N   1 
ATOM   2492 C  CA  . GLU A 1 353 ? -6.842  -25.560 -31.650 1.00 25.40  ? 616  GLU A CA  1 
ATOM   2493 C  C   . GLU A 1 353 ? -5.354  -25.771 -31.306 1.00 25.07  ? 616  GLU A C   1 
ATOM   2494 O  O   . GLU A 1 353 ? -4.484  -25.533 -32.154 1.00 25.50  ? 616  GLU A O   1 
ATOM   2495 C  CB  . GLU A 1 353 ? -7.412  -24.389 -30.866 1.00 27.33  ? 616  GLU A CB  1 
ATOM   2496 C  CG  . GLU A 1 353 ? -6.764  -23.055 -31.178 1.00 29.82  ? 616  GLU A CG  1 
ATOM   2497 C  CD  . GLU A 1 353 ? -7.080  -22.059 -30.076 1.00 33.05  ? 616  GLU A CD  1 
ATOM   2498 O  OE1 . GLU A 1 353 ? -8.274  -21.688 -29.970 1.00 34.26  ? 616  GLU A OE1 1 
ATOM   2499 O  OE2 . GLU A 1 353 ? -6.157  -21.754 -29.247 1.00 31.76  ? 616  GLU A OE2 1 
ATOM   2500 N  N   . ALA A 1 354 ? -5.073  -26.136 -30.062 1.00 25.31  ? 617  ALA A N   1 
ATOM   2501 C  CA  . ALA A 1 354 ? -3.709  -26.351 -29.535 1.00 24.39  ? 617  ALA A CA  1 
ATOM   2502 C  C   . ALA A 1 354 ? -2.976  -27.402 -30.362 1.00 26.57  ? 617  ALA A C   1 
ATOM   2503 O  O   . ALA A 1 354 ? -1.798  -27.183 -30.693 1.00 26.01  ? 617  ALA A O   1 
ATOM   2504 C  CB  . ALA A 1 354 ? -3.794  -26.759 -28.114 1.00 23.27  ? 617  ALA A CB  1 
ATOM   2505 N  N   . GLN A 1 355 ? -3.638  -28.509 -30.725 1.00 22.76  ? 618  GLN A N   1 
ATOM   2506 C  CA  . GLN A 1 355 ? -2.973  -29.566 -31.518 1.00 22.53  ? 618  GLN A CA  1 
ATOM   2507 C  C   . GLN A 1 355 ? -2.753  -29.120 -32.977 1.00 23.41  ? 618  GLN A C   1 
ATOM   2508 O  O   . GLN A 1 355 ? -1.758  -29.567 -33.592 1.00 23.29  ? 618  GLN A O   1 
ATOM   2509 C  CB  . GLN A 1 355 ? -3.749  -30.886 -31.416 1.00 21.80  ? 618  GLN A CB  1 
ATOM   2510 C  CG  . GLN A 1 355 ? -3.955  -31.390 -30.003 1.00 21.60  ? 618  GLN A CG  1 
ATOM   2511 C  CD  . GLN A 1 355 ? -2.683  -31.546 -29.218 1.00 24.66  ? 618  GLN A CD  1 
ATOM   2512 O  OE1 . GLN A 1 355 ? -1.653  -31.963 -29.717 1.00 24.93  ? 618  GLN A OE1 1 
ATOM   2513 N  NE2 . GLN A 1 355 ? -2.772  -31.268 -27.941 1.00 25.42  ? 618  GLN A NE2 1 
ATOM   2514 N  N   . LEU A 1 356 ? -3.632  -28.326 -33.604 1.00 24.62  ? 619  LEU A N   1 
ATOM   2515 C  CA  . LEU A 1 356 ? -3.360  -27.827 -34.983 1.00 25.93  ? 619  LEU A CA  1 
ATOM   2516 C  C   . LEU A 1 356 ? -2.116  -26.934 -34.938 1.00 25.50  ? 619  LEU A C   1 
ATOM   2517 O  O   . LEU A 1 356 ? -1.305  -26.998 -35.874 1.00 28.58  ? 619  LEU A O   1 
ATOM   2518 C  CB  . LEU A 1 356 ? -4.523  -26.984 -35.531 1.00 26.20  ? 619  LEU A CB  1 
ATOM   2519 C  CG  . LEU A 1 356 ? -5.677  -27.750 -36.156 1.00 29.75  ? 619  LEU A CG  1 
ATOM   2520 C  CD1 . LEU A 1 356 ? -6.782  -26.768 -36.531 1.00 30.08  ? 619  LEU A CD1 1 
ATOM   2521 C  CD2 . LEU A 1 356 ? -5.250  -28.572 -37.364 1.00 30.04  ? 619  LEU A CD2 1 
ATOM   2522 N  N   . ILE A 1 357 ? -1.988  -26.145 -33.895 1.00 24.70  ? 620  ILE A N   1 
ATOM   2523 C  CA  . ILE A 1 357 ? -0.823  -25.223 -33.734 1.00 27.68  ? 620  ILE A CA  1 
ATOM   2524 C  C   . ILE A 1 357 ? 0.445   -26.065 -33.529 1.00 29.93  ? 620  ILE A C   1 
ATOM   2525 O  O   . ILE A 1 357 ? 1.451   -25.774 -34.199 1.00 27.40  ? 620  ILE A O   1 
ATOM   2526 C  CB  . ILE A 1 357 ? -1.063  -24.206 -32.615 1.00 27.48  ? 620  ILE A CB  1 
ATOM   2527 C  CG1 . ILE A 1 357 ? -2.198  -23.257 -33.028 1.00 28.33  ? 620  ILE A CG1 1 
ATOM   2528 C  CG2 . ILE A 1 357 ? 0.205   -23.424 -32.296 1.00 30.59  ? 620  ILE A CG2 1 
ATOM   2529 C  CD1 . ILE A 1 357 ? -2.721  -22.394 -31.923 1.00 29.35  ? 620  ILE A CD1 1 
ATOM   2530 N  N   . ARG A 1 358 ? 0.403   -27.113 -32.700 1.00 25.99  ? 621  ARG A N   1 
ATOM   2531 C  CA  . ARG A 1 358 ? 1.579   -27.989 -32.569 1.00 25.00  ? 621  ARG A CA  1 
ATOM   2532 C  C   . ARG A 1 358 ? 1.904   -28.616 -33.918 1.00 26.14  ? 621  ARG A C   1 
ATOM   2533 O  O   . ARG A 1 358 ? 3.126   -28.699 -34.253 1.00 28.53  ? 621  ARG A O   1 
ATOM   2534 C  CB  . ARG A 1 358 ? 1.403   -29.007 -31.446 1.00 28.22  ? 621  ARG A CB  1 
ATOM   2535 C  CG  . ARG A 1 358 ? 2.638   -29.866 -31.278 1.00 27.77  ? 621  ARG A CG  1 
ATOM   2536 C  CD  . ARG A 1 358 ? 2.560   -30.743 -30.054 1.00 28.31  ? 621  ARG A CD  1 
ATOM   2537 N  NE  . ARG A 1 358 ? 3.748   -31.596 -29.936 1.00 26.27  ? 621  ARG A NE  1 
ATOM   2538 C  CZ  . ARG A 1 358 ? 3.903   -32.579 -29.045 1.00 28.09  ? 621  ARG A CZ  1 
ATOM   2539 N  NH1 . ARG A 1 358 ? 2.918   -32.948 -28.239 1.00 24.51  ? 621  ARG A NH1 1 
ATOM   2540 N  NH2 . ARG A 1 358 ? 5.068   -33.234 -29.001 1.00 29.51  ? 621  ARG A NH2 1 
ATOM   2541 N  N   . GLN A 1 359 ? 0.911   -29.057 -34.701 1.00 24.70  ? 622  GLN A N   1 
ATOM   2542 C  CA  . GLN A 1 359 ? 1.176   -29.559 -36.066 1.00 23.53  ? 622  GLN A CA  1 
ATOM   2543 C  C   . GLN A 1 359 ? 1.835   -28.412 -36.898 1.00 27.36  ? 622  GLN A C   1 
ATOM   2544 O  O   . GLN A 1 359 ? 2.799   -28.687 -37.664 1.00 32.21  ? 622  GLN A O   1 
ATOM   2545 C  CB  . GLN A 1 359 ? -0.063  -30.105 -36.760 1.00 25.63  ? 622  GLN A CB  1 
ATOM   2546 C  CG  . GLN A 1 359 ? -0.646  -31.379 -36.134 1.00 24.15  ? 622  GLN A CG  1 
ATOM   2547 C  CD  . GLN A 1 359 ? -1.611  -32.057 -37.066 1.00 26.48  ? 622  GLN A CD  1 
ATOM   2548 O  OE1 . GLN A 1 359 ? -1.261  -32.528 -38.143 1.00 24.57  ? 622  GLN A OE1 1 
ATOM   2549 N  NE2 . GLN A 1 359 ? -2.863  -32.149 -36.639 1.00 27.20  ? 622  GLN A NE2 1 
ATOM   2550 N  N   . MET A 1 360 ? 1.337   -27.188 -36.849 1.00 27.09  ? 623  MET A N   1 
ATOM   2551 C  CA  . MET A 1 360 ? 1.980   -26.081 -37.639 1.00 29.40  ? 623  MET A CA  1 
ATOM   2552 C  C   . MET A 1 360 ? 3.460   -25.960 -37.228 1.00 30.44  ? 623  MET A C   1 
ATOM   2553 O  O   . MET A 1 360 ? 4.324   -25.811 -38.130 1.00 32.16  ? 623  MET A O   1 
ATOM   2554 C  CB  . MET A 1 360 ? 1.302   -24.734 -37.382 1.00 31.34  ? 623  MET A CB  1 
ATOM   2555 C  CG  . MET A 1 360 ? -0.043  -24.575 -38.025 1.00 35.83  ? 623  MET A CG  1 
ATOM   2556 S  SD  . MET A 1 360 ? -0.746  -23.040 -37.374 1.00 37.11  ? 623  MET A SD  1 
ATOM   2557 C  CE  . MET A 1 360 ? -2.508  -23.337 -37.485 1.00 39.13  ? 623  MET A CE  1 
ATOM   2558 N  N   . GLU A 1 361 ? 3.731   -25.966 -35.931 1.00 28.30  ? 624  GLU A N   1 
ATOM   2559 C  CA  . GLU A 1 361 ? 5.109   -25.835 -35.438 1.00 31.32  ? 624  GLU A CA  1 
ATOM   2560 C  C   . GLU A 1 361 ? 5.965   -26.939 -36.036 1.00 35.50  ? 624  GLU A C   1 
ATOM   2561 O  O   . GLU A 1 361 ? 7.076   -26.630 -36.495 1.00 33.26  ? 624  GLU A O   1 
ATOM   2562 C  CB  . GLU A 1 361 ? 5.176   -25.848 -33.926 1.00 31.64  ? 624  GLU A CB  1 
ATOM   2563 C  CG  . GLU A 1 361 ? 6.561   -25.499 -33.428 1.00 35.09  ? 624  GLU A CG  1 
ATOM   2564 C  CD  . GLU A 1 361 ? 6.670   -25.250 -31.942 1.00 37.16  ? 624  GLU A CD  1 
ATOM   2565 O  OE1 . GLU A 1 361 ? 7.810   -25.228 -31.425 1.00 37.82  ? 624  GLU A OE1 1 
ATOM   2566 O  OE2 . GLU A 1 361 ? 5.642   -25.026 -31.305 1.00 34.41  ? 624  GLU A OE2 1 
ATOM   2567 N  N   . GLY A 1 362 ? 5.504   -28.189 -36.015 1.00 30.19  ? 625  GLY A N   1 
ATOM   2568 C  CA  . GLY A 1 362 ? 6.285   -29.324 -36.521 1.00 31.18  ? 625  GLY A CA  1 
ATOM   2569 C  C   . GLY A 1 362 ? 6.568   -29.155 -38.018 1.00 35.43  ? 625  GLY A C   1 
ATOM   2570 O  O   . GLY A 1 362 ? 7.661   -29.547 -38.470 1.00 31.83  ? 625  GLY A O   1 
ATOM   2571 N  N   . GLU A 1 363 ? 5.630   -28.577 -38.760 1.00 27.73  ? 626  GLU A N   1 
ATOM   2572 C  CA  . GLU A 1 363 ? 5.730   -28.458 -40.235 1.00 29.00  ? 626  GLU A CA  1 
ATOM   2573 C  C   . GLU A 1 363 ? 6.498   -27.180 -40.604 1.00 29.83  ? 626  GLU A C   1 
ATOM   2574 O  O   . GLU A 1 363 ? 6.601   -26.904 -41.793 1.00 31.21  ? 626  GLU A O   1 
ATOM   2575 C  CB  . GLU A 1 363 ? 4.337   -28.459 -40.866 1.00 29.15  ? 626  GLU A CB  1 
ATOM   2576 C  CG  . GLU A 1 363 ? 3.729   -29.874 -40.909 1.00 29.31  ? 626  GLU A CG  1 
ATOM   2577 C  CD  . GLU A 1 363 ? 2.326   -29.962 -41.472 1.00 38.33  ? 626  GLU A CD  1 
ATOM   2578 O  OE1 . GLU A 1 363 ? 2.105   -29.359 -42.568 1.00 32.51  ? 626  GLU A OE1 1 
ATOM   2579 O  OE2 . GLU A 1 363 ? 1.444   -30.634 -40.807 1.00 29.59  ? 626  GLU A OE2 1 
ATOM   2580 N  N   . GLY A 1 364 ? 6.922   -26.395 -39.633 1.00 29.41  ? 627  GLY A N   1 
ATOM   2581 C  CA  . GLY A 1 364 ? 7.693   -25.158 -39.892 1.00 37.19  ? 627  GLY A CA  1 
ATOM   2582 C  C   . GLY A 1 364 ? 6.856   -24.030 -40.471 1.00 43.21  ? 627  GLY A C   1 
ATOM   2583 O  O   . GLY A 1 364 ? 7.427   -23.228 -41.256 1.00 42.78  ? 627  GLY A O   1 
ATOM   2584 N  N   . VAL A 1 365 ? 5.572   -23.899 -40.104 1.00 33.17  ? 628  VAL A N   1 
ATOM   2585 C  CA  . VAL A 1 365 ? 4.694   -22.871 -40.739 1.00 36.47  ? 628  VAL A CA  1 
ATOM   2586 C  C   . VAL A 1 365 ? 5.086   -21.500 -40.166 1.00 37.52  ? 628  VAL A C   1 
ATOM   2587 O  O   . VAL A 1 365 ? 4.930   -20.510 -40.872 1.00 41.66  ? 628  VAL A O   1 
ATOM   2588 C  CB  . VAL A 1 365 ? 3.196   -23.205 -40.569 1.00 36.61  ? 628  VAL A CB  1 
ATOM   2589 C  CG1 . VAL A 1 365 ? 2.292   -22.120 -41.145 1.00 37.40  ? 628  VAL A CG1 1 
ATOM   2590 C  CG2 . VAL A 1 365 ? 2.872   -24.531 -41.231 1.00 36.90  ? 628  VAL A CG2 1 
ATOM   2591 N  N   . PHE A 1 366 ? 5.559   -21.462 -38.923 1.00 41.48  ? 629  PHE A N   1 
ATOM   2592 C  CA  . PHE A 1 366 ? 6.083   -20.264 -38.217 1.00 42.87  ? 629  PHE A CA  1 
ATOM   2593 C  C   . PHE A 1 366 ? 7.417   -20.636 -37.558 1.00 51.15  ? 629  PHE A C   1 
ATOM   2594 O  O   . PHE A 1 366 ? 7.633   -21.823 -37.290 1.00 49.03  ? 629  PHE A O   1 
ATOM   2595 C  CB  . PHE A 1 366 ? 5.068   -19.733 -37.199 1.00 42.05  ? 629  PHE A CB  1 
ATOM   2596 C  CG  . PHE A 1 366 ? 4.832   -20.629 -36.017 1.00 41.56  ? 629  PHE A CG  1 
ATOM   2597 C  CD1 . PHE A 1 366 ? 3.875   -21.630 -36.084 1.00 39.80  ? 629  PHE A CD1 1 
ATOM   2598 C  CD2 . PHE A 1 366 ? 5.537   -20.463 -34.836 1.00 40.55  ? 629  PHE A CD2 1 
ATOM   2599 C  CE1 . PHE A 1 366 ? 3.649   -22.454 -34.992 1.00 38.56  ? 629  PHE A CE1 1 
ATOM   2600 C  CE2 . PHE A 1 366 ? 5.319   -21.302 -33.756 1.00 47.32  ? 629  PHE A CE2 1 
ATOM   2601 C  CZ  . PHE A 1 366 ? 4.375   -22.306 -33.840 1.00 38.12  ? 629  PHE A CZ  1 
ATOM   2602 N  N   . LYS A 1 367 ? 8.299   -19.656 -37.332 1.00 52.47  ? 630  LYS A N   1 
ATOM   2603 C  CA  . LYS A 1 367 ? 9.694   -19.900 -36.889 1.00 55.46  ? 630  LYS A CA  1 
ATOM   2604 C  C   . LYS A 1 367 ? 9.781   -19.693 -35.379 1.00 49.81  ? 630  LYS A C   1 
ATOM   2605 O  O   . LYS A 1 367 ? 10.548  -20.434 -34.732 1.00 51.05  ? 630  LYS A O   1 
ATOM   2606 C  CB  . LYS A 1 367 ? 10.642  -18.980 -37.664 1.00 68.63  ? 630  LYS A CB  1 
ATOM   2607 C  CG  . LYS A 1 367 ? 12.126  -19.298 -37.534 1.00 76.30  ? 630  LYS A CG  1 
ATOM   2608 C  CD  . LYS A 1 367 ? 12.987  -18.517 -38.512 1.00 80.04  ? 630  LYS A CD  1 
ATOM   2609 C  CE  . LYS A 1 367 ? 14.442  -18.447 -38.101 1.00 83.97  ? 630  LYS A CE  1 
ATOM   2610 N  NZ  . LYS A 1 367 ? 14.638  -17.567 -36.924 1.00 87.52  ? 630  LYS A NZ  1 
ATOM   2611 N  N   . SER A 1 368 ? 9.005   -18.759 -34.828 1.00 43.93  ? 631  SER A N   1 
ATOM   2612 C  CA  . SER A 1 368 ? 9.102   -18.358 -33.401 1.00 44.70  ? 631  SER A CA  1 
ATOM   2613 C  C   . SER A 1 368 ? 7.772   -17.843 -32.853 1.00 43.19  ? 631  SER A C   1 
ATOM   2614 O  O   . SER A 1 368 ? 7.103   -17.062 -33.541 1.00 44.66  ? 631  SER A O   1 
ATOM   2615 C  CB  . SER A 1 368 ? 10.148  -17.301 -33.220 1.00 51.92  ? 631  SER A CB  1 
ATOM   2616 O  OG  . SER A 1 368 ? 10.231  -16.903 -31.854 1.00 55.83  ? 631  SER A OG  1 
ATOM   2617 N  N   . ILE A 1 369 ? 7.490   -18.192 -31.598 1.00 44.99  ? 632  ILE A N   1 
ATOM   2618 C  CA  . ILE A 1 369 ? 6.262   -17.812 -30.842 1.00 44.91  ? 632  ILE A CA  1 
ATOM   2619 C  C   . ILE A 1 369 ? 6.421   -16.391 -30.297 1.00 47.71  ? 632  ILE A C   1 
ATOM   2620 O  O   . ILE A 1 369 ? 5.441   -15.840 -29.734 1.00 42.46  ? 632  ILE A O   1 
ATOM   2621 C  CB  . ILE A 1 369 ? 6.007   -18.813 -29.702 1.00 45.65  ? 632  ILE A CB  1 
ATOM   2622 C  CG1 . ILE A 1 369 ? 7.164   -18.848 -28.712 1.00 41.59  ? 632  ILE A CG1 1 
ATOM   2623 C  CG2 . ILE A 1 369 ? 5.690   -20.198 -30.255 1.00 46.55  ? 632  ILE A CG2 1 
ATOM   2624 C  CD1 . ILE A 1 369 ? 6.838   -19.548 -27.436 1.00 44.52  ? 632  ILE A CD1 1 
ATOM   2625 N  N   . GLN A 1 370 ? 7.634   -15.838 -30.366 1.00 54.90  ? 633  GLN A N   1 
ATOM   2626 C  CA  . GLN A 1 370 ? 7.909   -14.495 -29.797 1.00 56.49  ? 633  GLN A CA  1 
ATOM   2627 C  C   . GLN A 1 370 ? 7.015   -13.503 -30.543 1.00 48.07  ? 633  GLN A C   1 
ATOM   2628 O  O   . GLN A 1 370 ? 6.409   -12.643 -29.894 1.00 46.48  ? 633  GLN A O   1 
ATOM   2629 C  CB  . GLN A 1 370 ? 9.400   -14.158 -29.867 1.00 58.10  ? 633  GLN A CB  1 
ATOM   2630 C  CG  . GLN A 1 370 ? 9.969   -13.747 -28.513 1.00 67.89  ? 633  GLN A CG  1 
ATOM   2631 C  CD  . GLN A 1 370 ? 10.039  -14.860 -27.491 1.00 69.72  ? 633  GLN A CD  1 
ATOM   2632 O  OE1 . GLN A 1 370 ? 10.271  -16.021 -27.815 1.00 80.15  ? 633  GLN A OE1 1 
ATOM   2633 N  NE2 . GLN A 1 370 ? 9.870   -14.511 -26.225 1.00 74.24  ? 633  GLN A NE2 1 
ATOM   2634 N  N   . HIS A 1 371 ? 6.899   -13.672 -31.857 1.00 47.75  ? 634  HIS A N   1 
ATOM   2635 C  CA  . HIS A 1 371 ? 6.199   -12.724 -32.747 1.00 54.30  ? 634  HIS A CA  1 
ATOM   2636 C  C   . HIS A 1 371 ? 6.024   -13.368 -34.123 1.00 55.24  ? 634  HIS A C   1 
ATOM   2637 O  O   . HIS A 1 371 ? 6.996   -13.970 -34.660 1.00 50.31  ? 634  HIS A O   1 
ATOM   2638 C  CB  . HIS A 1 371 ? 7.001   -11.404 -32.786 1.00 64.94  ? 634  HIS A CB  1 
ATOM   2639 C  CG  . HIS A 1 371 ? 6.941   -10.664 -34.081 1.00 71.00  ? 634  HIS A CG  1 
ATOM   2640 N  ND1 . HIS A 1 371 ? 5.947   -9.742  -34.361 1.00 78.61  ? 634  HIS A ND1 1 
ATOM   2641 C  CD2 . HIS A 1 371 ? 7.753   -10.686 -35.164 1.00 76.47  ? 634  HIS A CD2 1 
ATOM   2642 C  CE1 . HIS A 1 371 ? 6.142   -9.237  -35.568 1.00 75.92  ? 634  HIS A CE1 1 
ATOM   2643 N  NE2 . HIS A 1 371 ? 7.240   -9.805  -36.083 1.00 78.84  ? 634  HIS A NE2 1 
ATOM   2644 N  N   . LEU A 1 372 ? 4.816   -13.256 -34.682 0.50 55.87  ? 635  LEU A N   1 
ATOM   2645 C  CA  . LEU A 1 372 ? 4.502   -13.635 -36.085 0.50 59.72  ? 635  LEU A CA  1 
ATOM   2646 C  C   . LEU A 1 372 ? 4.693   -12.410 -36.983 0.50 61.70  ? 635  LEU A C   1 
ATOM   2647 O  O   . LEU A 1 372 ? 4.085   -11.365 -36.696 0.50 64.63  ? 635  LEU A O   1 
ATOM   2648 C  CB  . LEU A 1 372 ? 3.065   -14.159 -36.175 0.50 59.81  ? 635  LEU A CB  1 
ATOM   2649 C  CG  . LEU A 1 372 ? 2.935   -15.661 -36.416 0.50 60.10  ? 635  LEU A CG  1 
ATOM   2650 C  CD1 . LEU A 1 372 ? 3.566   -16.447 -35.278 0.50 60.68  ? 635  LEU A CD1 1 
ATOM   2651 C  CD2 . LEU A 1 372 ? 1.479   -16.056 -36.605 0.50 59.73  ? 635  LEU A CD2 1 
ATOM   2652 N  N   . THR A 1 373 ? 5.521   -12.544 -38.018 0.50 64.18  ? 636  THR A N   1 
ATOM   2653 C  CA  . THR A 1 373 ? 5.676   -11.550 -39.107 0.50 63.69  ? 636  THR A CA  1 
ATOM   2654 C  C   . THR A 1 373 ? 4.331   -11.437 -39.829 0.50 65.40  ? 636  THR A C   1 
ATOM   2655 O  O   . THR A 1 373 ? 3.450   -12.284 -39.562 0.50 65.60  ? 636  THR A O   1 
ATOM   2656 C  CB  . THR A 1 373 ? 6.827   -11.953 -40.033 0.50 63.79  ? 636  THR A CB  1 
ATOM   2657 O  OG1 . THR A 1 373 ? 6.387   -13.042 -40.846 0.50 65.31  ? 636  THR A OG1 1 
ATOM   2658 C  CG2 . THR A 1 373 ? 8.071   -12.348 -39.268 0.50 64.04  ? 636  THR A CG2 1 
ATOM   2659 N  N   . VAL A 1 374 ? 4.180   -10.436 -40.700 1.00 62.51  ? 637  VAL A N   1 
ATOM   2660 C  CA  . VAL A 1 374 ? 2.919   -10.214 -41.463 1.00 65.12  ? 637  VAL A CA  1 
ATOM   2661 C  C   . VAL A 1 374 ? 2.708   -11.407 -42.407 1.00 63.98  ? 637  VAL A C   1 
ATOM   2662 O  O   . VAL A 1 374 ? 1.551   -11.866 -42.536 1.00 62.45  ? 637  VAL A O   1 
ATOM   2663 C  CB  . VAL A 1 374 ? 2.947   -8.863  -42.213 1.00 69.48  ? 637  VAL A CB  1 
ATOM   2664 C  CG1 . VAL A 1 374 ? 3.322   -7.726  -41.279 1.00 68.93  ? 637  VAL A CG1 1 
ATOM   2665 C  CG2 . VAL A 1 374 ? 3.871   -8.876  -43.424 1.00 69.77  ? 637  VAL A CG2 1 
ATOM   2666 N  N   . THR A 1 375 ? 3.792   -11.904 -43.014 1.00 57.22  ? 638  THR A N   1 
ATOM   2667 C  CA  . THR A 1 375 ? 3.746   -12.971 -44.045 1.00 58.77  ? 638  THR A CA  1 
ATOM   2668 C  C   . THR A 1 375 ? 3.585   -14.346 -43.366 1.00 49.99  ? 638  THR A C   1 
ATOM   2669 O  O   . THR A 1 375 ? 3.136   -15.266 -44.060 1.00 52.38  ? 638  THR A O   1 
ATOM   2670 C  CB  . THR A 1 375 ? 4.966   -12.942 -44.977 1.00 58.68  ? 638  THR A CB  1 
ATOM   2671 O  OG1 . THR A 1 375 ? 6.091   -13.395 -44.225 1.00 66.06  ? 638  THR A OG1 1 
ATOM   2672 C  CG2 . THR A 1 375 ? 5.244   -11.578 -45.581 1.00 61.17  ? 638  THR A CG2 1 
ATOM   2673 N  N   . GLU A 1 376 ? 4.003   -14.498 -42.104 1.00 49.12  ? 639  GLU A N   1 
ATOM   2674 C  CA  . GLU A 1 376 ? 3.763   -15.754 -41.328 1.00 52.57  ? 639  GLU A CA  1 
ATOM   2675 C  C   . GLU A 1 376 ? 2.255   -15.826 -41.069 1.00 50.46  ? 639  GLU A C   1 
ATOM   2676 O  O   . GLU A 1 376 ? 1.676   -16.890 -41.328 1.00 51.16  ? 639  GLU A O   1 
ATOM   2677 C  CB  . GLU A 1 376 ? 4.608   -15.831 -40.056 1.00 50.72  ? 639  GLU A CB  1 
ATOM   2678 C  CG  . GLU A 1 376 ? 6.029   -16.341 -40.302 1.00 49.53  ? 639  GLU A CG  1 
ATOM   2679 C  CD  . GLU A 1 376 ? 6.949   -16.270 -39.096 1.00 47.28  ? 639  GLU A CD  1 
ATOM   2680 O  OE1 . GLU A 1 376 ? 7.888   -17.073 -39.028 1.00 51.99  ? 639  GLU A OE1 1 
ATOM   2681 O  OE2 . GLU A 1 376 ? 6.730   -15.414 -38.222 1.00 56.51  ? 639  GLU A OE2 1 
ATOM   2682 N  N   . GLU A 1 377 ? 1.621   -14.699 -40.724 1.00 53.71  ? 640  GLU A N   1 
ATOM   2683 C  CA  . GLU A 1 377 ? 0.143   -14.629 -40.548 1.00 50.86  ? 640  GLU A CA  1 
ATOM   2684 C  C   . GLU A 1 377 ? -0.553  -15.165 -41.798 1.00 53.47  ? 640  GLU A C   1 
ATOM   2685 O  O   . GLU A 1 377 ? -1.450  -15.994 -41.658 1.00 52.79  ? 640  GLU A O   1 
ATOM   2686 C  CB  . GLU A 1 377 ? -0.333  -13.215 -40.255 1.00 51.06  ? 640  GLU A CB  1 
ATOM   2687 C  CG  . GLU A 1 377 ? -0.092  -12.817 -38.822 1.00 55.68  ? 640  GLU A CG  1 
ATOM   2688 C  CD  . GLU A 1 377 ? -0.744  -11.505 -38.430 1.00 62.70  ? 640  GLU A CD  1 
ATOM   2689 O  OE1 . GLU A 1 377 ? -1.874  -11.252 -38.897 1.00 65.19  ? 640  GLU A OE1 1 
ATOM   2690 O  OE2 . GLU A 1 377 ? -0.122  -10.748 -37.648 1.00 67.85  ? 640  GLU A OE2 1 
ATOM   2691 N  N   . ILE A 1 378 ? -0.149  -14.726 -42.984 1.00 51.96  ? 641  ILE A N   1 
ATOM   2692 C  CA  . ILE A 1 378 ? -0.807  -15.152 -44.256 1.00 51.50  ? 641  ILE A CA  1 
ATOM   2693 C  C   . ILE A 1 378 ? -0.479  -16.638 -44.497 1.00 43.96  ? 641  ILE A C   1 
ATOM   2694 O  O   . ILE A 1 378 ? -1.330  -17.339 -45.043 1.00 47.34  ? 641  ILE A O   1 
ATOM   2695 C  CB  . ILE A 1 378 ? -0.446  -14.219 -45.447 1.00 54.11  ? 641  ILE A CB  1 
ATOM   2696 C  CG1 . ILE A 1 378 ? -0.592  -14.880 -46.824 1.00 54.39  ? 641  ILE A CG1 1 
ATOM   2697 C  CG2 . ILE A 1 378 ? 0.932   -13.622 -45.291 1.00 58.76  ? 641  ILE A CG2 1 
ATOM   2698 C  CD1 . ILE A 1 378 ? 0.677   -15.561 -47.341 1.00 60.38  ? 641  ILE A CD1 1 
ATOM   2699 N  N   . ALA A 1 379 ? 0.732   -17.080 -44.158 1.00 41.67  ? 642  ALA A N   1 
ATOM   2700 C  CA  . ALA A 1 379 ? 1.180   -18.486 -44.275 1.00 41.52  ? 642  ALA A CA  1 
ATOM   2701 C  C   . ALA A 1 379 ? 0.293   -19.397 -43.384 1.00 32.25  ? 642  ALA A C   1 
ATOM   2702 O  O   . ALA A 1 379 ? -0.159  -20.451 -43.878 1.00 36.00  ? 642  ALA A O   1 
ATOM   2703 C  CB  . ALA A 1 379 ? 2.640   -18.567 -43.890 1.00 42.52  ? 642  ALA A CB  1 
ATOM   2704 N  N   . VAL A 1 380 ? 0.070   -18.974 -42.144 1.00 33.26  ? 643  VAL A N   1 
ATOM   2705 C  CA  . VAL A 1 380 ? -0.768  -19.697 -41.142 1.00 38.79  ? 643  VAL A CA  1 
ATOM   2706 C  C   . VAL A 1 380 ? -2.202  -19.748 -41.683 1.00 42.64  ? 643  VAL A C   1 
ATOM   2707 O  O   . VAL A 1 380 ? -2.770  -20.882 -41.791 1.00 34.87  ? 643  VAL A O   1 
ATOM   2708 C  CB  . VAL A 1 380 ? -0.675  -19.044 -39.753 1.00 37.14  ? 643  VAL A CB  1 
ATOM   2709 C  CG1 . VAL A 1 380 ? -1.753  -19.577 -38.814 1.00 42.31  ? 643  VAL A CG1 1 
ATOM   2710 C  CG2 . VAL A 1 380 ? 0.702   -19.251 -39.133 1.00 36.22  ? 643  VAL A CG2 1 
ATOM   2711 N  N   . LYS A 1 381 ? -2.770  -18.596 -42.084 1.00 40.08  ? 644  LYS A N   1 
ATOM   2712 C  CA  . LYS A 1 381 ? -4.150  -18.563 -42.653 1.00 43.69  ? 644  LYS A CA  1 
ATOM   2713 C  C   . LYS A 1 381 ? -4.212  -19.525 -43.851 1.00 39.85  ? 644  LYS A C   1 
ATOM   2714 O  O   . LYS A 1 381 ? -5.182  -20.320 -43.978 1.00 38.28  ? 644  LYS A O   1 
ATOM   2715 C  CB  . LYS A 1 381 ? -4.546  -17.128 -43.043 1.00 51.34  ? 644  LYS A CB  1 
ATOM   2716 C  CG  . LYS A 1 381 ? -5.264  -16.320 -41.968 1.00 58.17  ? 644  LYS A CG  1 
ATOM   2717 C  CD  . LYS A 1 381 ? -4.723  -14.897 -41.780 1.00 65.98  ? 644  LYS A CD  1 
ATOM   2718 C  CE  . LYS A 1 381 ? -5.392  -14.133 -40.650 1.00 69.35  ? 644  LYS A CE  1 
ATOM   2719 N  NZ  . LYS A 1 381 ? -4.479  -13.145 -40.023 1.00 72.98  ? 644  LYS A NZ  1 
ATOM   2720 N  N   . ASN A 1 382 ? -3.206  -19.469 -44.723 1.00 39.37  ? 645  ASN A N   1 
ATOM   2721 C  CA  . ASN A 1 382 ? -3.215  -20.241 -45.987 1.00 41.33  ? 645  ASN A CA  1 
ATOM   2722 C  C   . ASN A 1 382 ? -3.084  -21.737 -45.687 1.00 36.17  ? 645  ASN A C   1 
ATOM   2723 O  O   . ASN A 1 382 ? -3.704  -22.553 -46.392 1.00 35.67  ? 645  ASN A O   1 
ATOM   2724 C  CB  . ASN A 1 382 ? -2.111  -19.805 -46.958 1.00 47.37  ? 645  ASN A CB  1 
ATOM   2725 C  CG  . ASN A 1 382 ? -2.487  -20.175 -48.375 1.00 57.80  ? 645  ASN A CG  1 
ATOM   2726 O  OD1 . ASN A 1 382 ? -3.564  -19.795 -48.841 1.00 69.12  ? 645  ASN A OD1 1 
ATOM   2727 N  ND2 . ASN A 1 382 ? -1.646  -20.949 -49.047 1.00 58.13  ? 645  ASN A ND2 1 
ATOM   2728 N  N   . TRP A 1 383 ? -2.265  -22.097 -44.698 1.00 37.60  ? 646  TRP A N   1 
ATOM   2729 C  CA  . TRP A 1 383 ? -2.134  -23.519 -44.253 1.00 34.94  ? 646  TRP A CA  1 
ATOM   2730 C  C   . TRP A 1 383 ? -3.535  -24.052 -43.854 1.00 29.14  ? 646  TRP A C   1 
ATOM   2731 O  O   . TRP A 1 383 ? -3.989  -25.076 -44.405 1.00 31.53  ? 646  TRP A O   1 
ATOM   2732 C  CB  . TRP A 1 383 ? -1.090  -23.581 -43.131 1.00 31.69  ? 646  TRP A CB  1 
ATOM   2733 C  CG  . TRP A 1 383 ? -0.685  -24.953 -42.673 1.00 37.74  ? 646  TRP A CG  1 
ATOM   2734 C  CD1 . TRP A 1 383 ? 0.320   -25.754 -43.153 1.00 39.32  ? 646  TRP A CD1 1 
ATOM   2735 C  CD2 . TRP A 1 383 ? -1.270  -25.676 -41.577 1.00 35.38  ? 646  TRP A CD2 1 
ATOM   2736 N  NE1 . TRP A 1 383 ? 0.430   -26.900 -42.407 1.00 37.41  ? 646  TRP A NE1 1 
ATOM   2737 C  CE2 . TRP A 1 383 ? -0.544  -26.885 -41.440 1.00 34.86  ? 646  TRP A CE2 1 
ATOM   2738 C  CE3 . TRP A 1 383 ? -2.338  -25.407 -40.718 1.00 31.80  ? 646  TRP A CE3 1 
ATOM   2739 C  CZ2 . TRP A 1 383 ? -0.846  -27.811 -40.441 1.00 31.30  ? 646  TRP A CZ2 1 
ATOM   2740 C  CZ3 . TRP A 1 383 ? -2.629  -26.320 -39.726 1.00 33.90  ? 646  TRP A CZ3 1 
ATOM   2741 C  CH2 . TRP A 1 383 ? -1.904  -27.504 -39.604 1.00 29.47  ? 646  TRP A CH2 1 
ATOM   2742 N  N   . LEU A 1 384 ? -4.224  -23.310 -43.003 1.00 33.10  ? 647  LEU A N   1 
ATOM   2743 C  CA  . LEU A 1 384 ? -5.581  -23.670 -42.492 1.00 37.57  ? 647  LEU A CA  1 
ATOM   2744 C  C   . LEU A 1 384 ? -6.548  -23.886 -43.663 1.00 38.28  ? 647  LEU A C   1 
ATOM   2745 O  O   . LEU A 1 384 ? -7.174  -24.952 -43.720 1.00 36.85  ? 647  LEU A O   1 
ATOM   2746 C  CB  . LEU A 1 384 ? -6.042  -22.585 -41.519 1.00 35.31  ? 647  LEU A CB  1 
ATOM   2747 C  CG  . LEU A 1 384 ? -5.337  -22.605 -40.161 1.00 34.54  ? 647  LEU A CG  1 
ATOM   2748 C  CD1 . LEU A 1 384 ? -5.731  -21.415 -39.326 1.00 35.32  ? 647  LEU A CD1 1 
ATOM   2749 C  CD2 . LEU A 1 384 ? -5.640  -23.884 -39.376 1.00 34.71  ? 647  LEU A CD2 1 
ATOM   2750 N  N   . VAL A 1 385 ? -6.636  -22.939 -44.602 1.00 39.77  ? 648  VAL A N   1 
ATOM   2751 C  CA  . VAL A 1 385 ? -7.531  -23.038 -45.786 1.00 40.31  ? 648  VAL A CA  1 
ATOM   2752 C  C   . VAL A 1 385 ? -7.137  -24.229 -46.661 1.00 37.36  ? 648  VAL A C   1 
ATOM   2753 O  O   . VAL A 1 385 ? -8.012  -24.954 -47.073 1.00 41.22  ? 648  VAL A O   1 
ATOM   2754 C  CB  . VAL A 1 385 ? -7.550  -21.716 -46.589 1.00 46.76  ? 648  VAL A CB  1 
ATOM   2755 C  CG1 . VAL A 1 385 ? -8.254  -21.872 -47.926 1.00 47.95  ? 648  VAL A CG1 1 
ATOM   2756 C  CG2 . VAL A 1 385 ? -8.189  -20.598 -45.775 1.00 49.75  ? 648  VAL A CG2 1 
ATOM   2757 N  N   . ARG A 1 386 ? -5.835  -24.410 -46.909 0.50 39.60  ? 649  ARG A N   1 
ATOM   2758 C  CA  . ARG A 1 386 ? -5.288  -25.436 -47.839 0.50 41.23  ? 649  ARG A CA  1 
ATOM   2759 C  C   . ARG A 1 386 ? -5.400  -26.844 -47.229 0.50 40.13  ? 649  ARG A C   1 
ATOM   2760 O  O   . ARG A 1 386 ? -5.891  -27.750 -47.934 0.50 39.01  ? 649  ARG A O   1 
ATOM   2761 C  CB  . ARG A 1 386 ? -3.832  -25.094 -48.178 0.50 46.49  ? 649  ARG A CB  1 
ATOM   2762 C  CG  . ARG A 1 386 ? -3.196  -25.995 -49.228 0.50 51.39  ? 649  ARG A CG  1 
ATOM   2763 C  CD  . ARG A 1 386 ? -1.824  -25.507 -49.682 0.50 54.73  ? 649  ARG A CD  1 
ATOM   2764 N  NE  . ARG A 1 386 ? -0.736  -25.824 -48.757 0.50 56.36  ? 649  ARG A NE  1 
ATOM   2765 C  CZ  . ARG A 1 386 ? -0.205  -24.969 -47.884 0.50 56.22  ? 649  ARG A CZ  1 
ATOM   2766 N  NH1 . ARG A 1 386 ? -0.663  -23.731 -47.806 0.50 57.56  ? 649  ARG A NH1 1 
ATOM   2767 N  NH2 . ARG A 1 386 ? 0.782   -25.352 -47.094 0.50 55.51  ? 649  ARG A NH2 1 
ATOM   2768 N  N   . VAL A 1 387 ? -4.939  -27.034 -45.987 1.00 37.51  ? 650  VAL A N   1 
ATOM   2769 C  CA  . VAL A 1 387 ? -4.815  -28.408 -45.396 1.00 39.24  ? 650  VAL A CA  1 
ATOM   2770 C  C   . VAL A 1 387 ? -5.481  -28.556 -44.025 1.00 34.10  ? 650  VAL A C   1 
ATOM   2771 O  O   . VAL A 1 387 ? -5.354  -29.681 -43.507 1.00 31.31  ? 650  VAL A O   1 
ATOM   2772 C  CB  . VAL A 1 387 ? -3.341  -28.846 -45.293 1.00 32.51  ? 650  VAL A CB  1 
ATOM   2773 C  CG1 . VAL A 1 387 ? -2.679  -28.966 -46.662 1.00 38.57  ? 650  VAL A CG1 1 
ATOM   2774 C  CG2 . VAL A 1 387 ? -2.552  -27.943 -44.355 1.00 33.56  ? 650  VAL A CG2 1 
ATOM   2775 N  N   . GLY A 1 388 ? -6.065  -27.498 -43.459 1.00 32.84  ? 651  GLY A N   1 
ATOM   2776 C  CA  . GLY A 1 388 ? -6.646  -27.498 -42.098 1.00 31.98  ? 651  GLY A CA  1 
ATOM   2777 C  C   . GLY A 1 388 ? -7.580  -28.688 -41.878 1.00 32.13  ? 651  GLY A C   1 
ATOM   2778 O  O   . GLY A 1 388 ? -7.429  -29.392 -40.865 1.00 29.74  ? 651  GLY A O   1 
ATOM   2779 N  N   . ARG A 1 389 ? -8.517  -28.936 -42.788 1.00 30.33  ? 652  ARG A N   1 
ATOM   2780 C  CA  . ARG A 1 389 ? -9.485  -30.053 -42.625 1.00 33.34  ? 652  ARG A CA  1 
ATOM   2781 C  C   . ARG A 1 389 ? -8.732  -31.390 -42.667 1.00 32.39  ? 652  ARG A C   1 
ATOM   2782 O  O   . ARG A 1 389 ? -9.072  -32.323 -41.877 1.00 28.40  ? 652  ARG A O   1 
ATOM   2783 C  CB  . ARG A 1 389 ? -10.595 -29.967 -43.676 1.00 34.34  ? 652  ARG A CB  1 
ATOM   2784 C  CG  . ARG A 1 389 ? -11.559 -28.818 -43.431 1.00 36.29  ? 652  ARG A CG  1 
ATOM   2785 C  CD  . ARG A 1 389 ? -12.607 -28.762 -44.525 1.00 37.40  ? 652  ARG A CD  1 
ATOM   2786 N  NE  . ARG A 1 389 ? -13.566 -29.839 -44.437 1.00 36.46  ? 652  ARG A NE  1 
ATOM   2787 C  CZ  . ARG A 1 389 ? -14.609 -29.870 -43.593 1.00 36.80  ? 652  ARG A CZ  1 
ATOM   2788 N  NH1 . ARG A 1 389 ? -14.842 -28.882 -42.744 1.00 38.06  ? 652  ARG A NH1 1 
ATOM   2789 N  NH2 . ARG A 1 389 ? -15.416 -30.910 -43.606 1.00 38.69  ? 652  ARG A NH2 1 
ATOM   2790 N  N   . GLU A 1 390 ? -7.731  -31.541 -43.540 1.00 29.11  ? 653  GLU A N   1 
ATOM   2791 C  CA  . GLU A 1 390 ? -6.943  -32.803 -43.580 1.00 30.96  ? 653  GLU A CA  1 
ATOM   2792 C  C   . GLU A 1 390 ? -6.233  -32.983 -42.228 1.00 26.66  ? 653  GLU A C   1 
ATOM   2793 O  O   . GLU A 1 390 ? -6.212  -34.144 -41.717 1.00 26.95  ? 653  GLU A O   1 
ATOM   2794 C  CB  . GLU A 1 390 ? -5.937  -32.806 -44.743 1.00 31.09  ? 653  GLU A CB  1 
ATOM   2795 C  CG  . GLU A 1 390 ? -5.403  -34.177 -45.106 1.00 30.38  ? 653  GLU A CG  1 
ATOM   2796 C  CD  . GLU A 1 390 ? -4.278  -34.737 -44.237 1.00 31.86  ? 653  GLU A CD  1 
ATOM   2797 O  OE1 . GLU A 1 390 ? -3.670  -33.979 -43.453 1.00 33.76  ? 653  GLU A OE1 1 
ATOM   2798 O  OE2 . GLU A 1 390 ? -4.063  -35.950 -44.291 1.00 38.78  ? 653  GLU A OE2 1 
ATOM   2799 N  N   . ARG A 1 391 ? -5.691  -31.910 -41.657 1.00 25.53  ? 654  ARG A N   1 
ATOM   2800 C  CA  . ARG A 1 391 ? -4.914  -32.003 -40.394 1.00 26.40  ? 654  ARG A CA  1 
ATOM   2801 C  C   . ARG A 1 391 ? -5.867  -32.332 -39.226 1.00 25.77  ? 654  ARG A C   1 
ATOM   2802 O  O   . ARG A 1 391 ? -5.430  -33.035 -38.288 1.00 23.78  ? 654  ARG A O   1 
ATOM   2803 C  CB  . ARG A 1 391 ? -4.088  -30.738 -40.181 1.00 28.79  ? 654  ARG A CB  1 
ATOM   2804 C  CG  . ARG A 1 391 ? -3.078  -30.539 -41.309 1.00 28.46  ? 654  ARG A CG  1 
ATOM   2805 C  CD  . ARG A 1 391 ? -2.088  -31.675 -41.454 1.00 31.35  ? 654  ARG A CD  1 
ATOM   2806 N  NE  . ARG A 1 391 ? -0.976  -31.212 -42.271 1.00 30.90  ? 654  ARG A NE  1 
ATOM   2807 C  CZ  . ARG A 1 391 ? -0.889  -31.335 -43.593 1.00 36.62  ? 654  ARG A CZ  1 
ATOM   2808 N  NH1 . ARG A 1 391 ? -1.785  -32.006 -44.303 1.00 35.84  ? 654  ARG A NH1 1 
ATOM   2809 N  NH2 . ARG A 1 391 ? 0.149   -30.797 -44.216 1.00 38.48  ? 654  ARG A NH2 1 
ATOM   2810 N  N   . LEU A 1 392 ? -7.117  -31.854 -39.281 1.00 24.43  ? 655  LEU A N   1 
ATOM   2811 C  CA  . LEU A 1 392 ? -8.132  -32.194 -38.237 1.00 24.02  ? 655  LEU A CA  1 
ATOM   2812 C  C   . LEU A 1 392 ? -8.421  -33.698 -38.280 1.00 25.12  ? 655  LEU A C   1 
ATOM   2813 O  O   . LEU A 1 392 ? -8.578  -34.325 -37.207 1.00 24.79  ? 655  LEU A O   1 
ATOM   2814 C  CB  . LEU A 1 392 ? -9.423  -31.401 -38.481 1.00 25.11  ? 655  LEU A CB  1 
ATOM   2815 C  CG  . LEU A 1 392 ? -9.420  -29.930 -38.087 1.00 24.01  ? 655  LEU A CG  1 
ATOM   2816 C  CD1 . LEU A 1 392 ? -10.781 -29.326 -38.449 1.00 25.99  ? 655  LEU A CD1 1 
ATOM   2817 C  CD2 . LEU A 1 392 ? -9.098  -29.724 -36.612 1.00 25.53  ? 655  LEU A CD2 1 
ATOM   2818 N  N   . SER A 1 393 ? -8.470  -34.263 -39.488 0.50 25.96  ? 656  SER A N   1 
ATOM   2819 C  CA  . SER A 1 393 ? -8.795  -35.685 -39.743 0.50 26.88  ? 656  SER A CA  1 
ATOM   2820 C  C   . SER A 1 393 ? -7.696  -36.584 -39.167 0.50 26.02  ? 656  SER A C   1 
ATOM   2821 O  O   . SER A 1 393 ? -7.966  -37.770 -38.970 0.50 24.88  ? 656  SER A O   1 
ATOM   2822 C  CB  . SER A 1 393 ? -9.027  -35.933 -41.214 0.50 29.07  ? 656  SER A CB  1 
ATOM   2823 O  OG  . SER A 1 393 ? -7.872  -35.612 -41.982 0.50 30.21  ? 656  SER A OG  1 
ATOM   2824 N  N   . ARG A 1 394 ? -6.501  -36.032 -38.905 0.50 25.11  ? 657  ARG A N   1 
ATOM   2825 C  CA  . ARG A 1 394 ? -5.345  -36.782 -38.347 0.50 24.73  ? 657  ARG A CA  1 
ATOM   2826 C  C   . ARG A 1 394 ? -5.428  -36.836 -36.821 0.50 23.32  ? 657  ARG A C   1 
ATOM   2827 O  O   . ARG A 1 394 ? -4.419  -37.228 -36.196 0.50 22.27  ? 657  ARG A O   1 
ATOM   2828 C  CB  . ARG A 1 394 ? -4.018  -36.122 -38.740 0.50 26.18  ? 657  ARG A CB  1 
ATOM   2829 C  CG  . ARG A 1 394 ? -3.704  -36.199 -40.223 0.50 27.86  ? 657  ARG A CG  1 
ATOM   2830 C  CD  . ARG A 1 394 ? -2.447  -35.443 -40.615 0.50 28.07  ? 657  ARG A CD  1 
ATOM   2831 N  NE  . ARG A 1 394 ? -2.068  -35.944 -41.921 0.50 28.87  ? 657  ARG A NE  1 
ATOM   2832 C  CZ  . ARG A 1 394 ? -1.272  -36.977 -42.124 0.50 30.65  ? 657  ARG A CZ  1 
ATOM   2833 N  NH1 . ARG A 1 394 ? -0.693  -37.580 -41.099 0.50 30.21  ? 657  ARG A NH1 1 
ATOM   2834 N  NH2 . ARG A 1 394 ? -1.038  -37.391 -43.358 0.50 31.86  ? 657  ARG A NH2 1 
ATOM   2835 N  N   . MET A 1 395 ? -6.561  -36.439 -36.230 1.00 21.49  ? 658  MET A N   1 
ATOM   2836 C  CA  . MET A 1 395 ? -6.689  -36.391 -34.768 1.00 21.33  ? 658  MET A CA  1 
ATOM   2837 C  C   . MET A 1 395 ? -7.996  -37.063 -34.307 1.00 21.37  ? 658  MET A C   1 
ATOM   2838 O  O   . MET A 1 395 ? -8.991  -37.081 -35.053 1.00 20.97  ? 658  MET A O   1 
ATOM   2839 C  CB  . MET A 1 395 ? -6.592  -34.945 -34.270 1.00 21.89  ? 658  MET A CB  1 
ATOM   2840 C  CG  . MET A 1 395 ? -5.387  -34.176 -34.888 1.00 22.37  ? 658  MET A CG  1 
ATOM   2841 S  SD  . MET A 1 395 ? -4.988  -32.685 -34.045 1.00 23.63  ? 658  MET A SD  1 
ATOM   2842 C  CE  . MET A 1 395 ? -6.313  -31.615 -34.614 1.00 24.20  ? 658  MET A CE  1 
ATOM   2843 N  N   . ALA A 1 396 ? -7.938  -37.601 -33.095 1.00 20.18  ? 659  ALA A N   1 
ATOM   2844 C  CA  . ALA A 1 396 ? -9.114  -38.029 -32.314 1.00 20.17  ? 659  ALA A CA  1 
ATOM   2845 C  C   . ALA A 1 396 ? -9.052  -37.310 -30.977 1.00 20.62  ? 659  ALA A C   1 
ATOM   2846 O  O   . ALA A 1 396 ? -8.060  -37.455 -30.246 1.00 20.05  ? 659  ALA A O   1 
ATOM   2847 C  CB  . ALA A 1 396 ? -9.123  -39.520 -32.165 1.00 21.28  ? 659  ALA A CB  1 
ATOM   2848 N  N   . ILE A 1 397 ? -10.028 -36.441 -30.726 1.00 19.77  ? 660  ILE A N   1 
ATOM   2849 C  CA  . ILE A 1 397 ? -9.981  -35.522 -29.573 1.00 18.90  ? 660  ILE A CA  1 
ATOM   2850 C  C   . ILE A 1 397 ? -11.299 -35.602 -28.803 1.00 21.49  ? 660  ILE A C   1 
ATOM   2851 O  O   . ILE A 1 397 ? -12.378 -35.367 -29.373 1.00 20.54  ? 660  ILE A O   1 
ATOM   2852 C  CB  . ILE A 1 397 ? -9.643  -34.094 -30.017 1.00 20.62  ? 660  ILE A CB  1 
ATOM   2853 C  CG1 . ILE A 1 397 ? -8.318  -34.093 -30.771 1.00 23.06  ? 660  ILE A CG1 1 
ATOM   2854 C  CG2 . ILE A 1 397 ? -9.658  -33.162 -28.808 1.00 21.01  ? 660  ILE A CG2 1 
ATOM   2855 C  CD1 . ILE A 1 397 ? -7.771  -32.724 -31.151 1.00 25.14  ? 660  ILE A CD1 1 
ATOM   2856 N  N   . SER A 1 398 ? -11.159 -35.919 -27.524 1.00 20.51  ? 661  SER A N   1 
ATOM   2857 C  CA  . SER A 1 398 ? -12.279 -36.073 -26.572 1.00 22.11  ? 661  SER A CA  1 
ATOM   2858 C  C   . SER A 1 398 ? -11.965 -35.213 -25.357 1.00 22.68  ? 661  SER A C   1 
ATOM   2859 O  O   . SER A 1 398 ? -11.186 -35.645 -24.464 1.00 21.82  ? 661  SER A O   1 
ATOM   2860 C  CB  . SER A 1 398 ? -12.497 -37.518 -26.232 1.00 24.43  ? 661  SER A CB  1 
ATOM   2861 O  OG  . SER A 1 398 ? -13.688 -37.633 -25.495 1.00 23.17  ? 661  SER A OG  1 
ATOM   2862 N  N   . GLY A 1 399 ? -12.447 -33.972 -25.363 1.00 23.32  ? 662  GLY A N   1 
ATOM   2863 C  CA  . GLY A 1 399 ? -12.058 -33.023 -24.309 1.00 23.82  ? 662  GLY A CA  1 
ATOM   2864 C  C   . GLY A 1 399 ? -10.550 -32.843 -24.216 1.00 23.89  ? 662  GLY A C   1 
ATOM   2865 O  O   . GLY A 1 399 ? -9.914  -32.515 -25.260 1.00 24.96  ? 662  GLY A O   1 
ATOM   2866 N  N   . ASP A 1 400 ? -9.952  -33.079 -23.036 1.00 23.97  ? 663  ASP A N   1 
ATOM   2867 C  CA  . ASP A 1 400 ? -8.490  -32.908 -22.838 1.00 26.32  ? 663  ASP A CA  1 
ATOM   2868 C  C   . ASP A 1 400 ? -7.703  -34.097 -23.392 1.00 25.20  ? 663  ASP A C   1 
ATOM   2869 O  O   . ASP A 1 400 ? -6.473  -34.042 -23.356 1.00 25.76  ? 663  ASP A O   1 
ATOM   2870 C  CB  . ASP A 1 400 ? -8.141  -32.668 -21.372 1.00 30.62  ? 663  ASP A CB  1 
ATOM   2871 C  CG  . ASP A 1 400 ? -8.545  -33.768 -20.396 1.00 34.79  ? 663  ASP A CG  1 
ATOM   2872 O  OD1 . ASP A 1 400 ? -9.229  -34.696 -20.780 1.00 36.67  ? 663  ASP A OD1 1 
ATOM   2873 O  OD2 . ASP A 1 400 ? -8.162  -33.663 -19.234 1.00 43.10  ? 663  ASP A OD2 1 
ATOM   2874 N  N   . ASP A 1 401 ? -8.368  -35.120 -23.901 1.00 23.35  ? 664  ASP A N   1 
ATOM   2875 C  CA  . ASP A 1 401 ? -7.696  -36.363 -24.369 1.00 22.47  ? 664  ASP A CA  1 
ATOM   2876 C  C   . ASP A 1 401 ? -7.491  -36.286 -25.874 1.00 22.28  ? 664  ASP A C   1 
ATOM   2877 O  O   . ASP A 1 401 ? -8.473  -35.991 -26.607 1.00 25.64  ? 664  ASP A O   1 
ATOM   2878 C  CB  . ASP A 1 401 ? -8.536  -37.585 -23.984 1.00 25.15  ? 664  ASP A CB  1 
ATOM   2879 C  CG  . ASP A 1 401 ? -7.710  -38.842 -23.881 1.00 33.38  ? 664  ASP A CG  1 
ATOM   2880 O  OD1 . ASP A 1 401 ? -6.532  -38.726 -24.116 1.00 34.11  ? 664  ASP A OD1 1 
ATOM   2881 O  OD2 . ASP A 1 401 ? -8.255  -39.871 -23.507 1.00 34.35  ? 664  ASP A OD2 1 
ATOM   2882 N  N   . CYS A 1 402 ? -6.285  -36.508 -26.367 1.00 21.60  ? 665  CYS A N   1 
ATOM   2883 C  CA  . CYS A 1 402 ? -6.040  -36.484 -27.822 1.00 22.04  ? 665  CYS A CA  1 
ATOM   2884 C  C   . CYS A 1 402 ? -5.147  -37.628 -28.287 1.00 21.92  ? 665  CYS A C   1 
ATOM   2885 O  O   . CYS A 1 402 ? -4.289  -38.103 -27.518 1.00 23.88  ? 665  CYS A O   1 
ATOM   2886 C  CB  . CYS A 1 402 ? -5.433  -35.170 -28.285 1.00 25.18  ? 665  CYS A CB  1 
ATOM   2887 S  SG  . CYS A 1 402 ? -3.809  -34.818 -27.562 1.00 31.66  ? 665  CYS A SG  1 
ATOM   2888 N  N   . VAL A 1 403 ? -5.347  -37.982 -29.546 1.00 20.27  ? 666  VAL A N   1 
ATOM   2889 C  CA  . VAL A 1 403 ? -4.436  -38.819 -30.368 1.00 21.23  ? 666  VAL A CA  1 
ATOM   2890 C  C   . VAL A 1 403 ? -4.204  -38.036 -31.661 1.00 21.55  ? 666  VAL A C   1 
ATOM   2891 O  O   . VAL A 1 403 ? -5.174  -37.553 -32.244 1.00 21.30  ? 666  VAL A O   1 
ATOM   2892 C  CB  . VAL A 1 403 ? -5.000  -40.227 -30.627 1.00 22.09  ? 666  VAL A CB  1 
ATOM   2893 C  CG1 . VAL A 1 403 ? -4.063  -41.047 -31.506 1.00 24.19  ? 666  VAL A CG1 1 
ATOM   2894 C  CG2 . VAL A 1 403 ? -5.295  -40.924 -29.292 1.00 22.74  ? 666  VAL A CG2 1 
ATOM   2895 N  N   . VAL A 1 404 ? -2.936  -37.886 -32.029 1.00 20.99  ? 667  VAL A N   1 
ATOM   2896 C  CA  . VAL A 1 404 ? -2.531  -37.103 -33.231 1.00 20.41  ? 667  VAL A CA  1 
ATOM   2897 C  C   . VAL A 1 404 ? -1.591  -37.972 -34.045 1.00 20.95  ? 667  VAL A C   1 
ATOM   2898 O  O   . VAL A 1 404 ? -0.595  -38.468 -33.452 1.00 23.21  ? 667  VAL A O   1 
ATOM   2899 C  CB  . VAL A 1 404 ? -1.863  -35.759 -32.853 1.00 22.19  ? 667  VAL A CB  1 
ATOM   2900 C  CG1 . VAL A 1 404 ? -1.511  -34.966 -34.110 1.00 23.71  ? 667  VAL A CG1 1 
ATOM   2901 C  CG2 . VAL A 1 404 ? -2.717  -34.915 -31.910 1.00 23.46  ? 667  VAL A CG2 1 
ATOM   2902 N  N   . LYS A 1 405 ? -1.866  -38.164 -35.331 1.00 22.72  ? 668  LYS A N   1 
ATOM   2903 C  CA  . LYS A 1 405 ? -0.906  -38.761 -36.301 1.00 21.43  ? 668  LYS A CA  1 
ATOM   2904 C  C   . LYS A 1 405 ? -0.418  -37.646 -37.233 1.00 23.48  ? 668  LYS A C   1 
ATOM   2905 O  O   . LYS A 1 405 ? -1.038  -37.390 -38.274 1.00 23.01  ? 668  LYS A O   1 
ATOM   2906 C  CB  . LYS A 1 405 ? -1.453  -39.888 -37.150 1.00 23.58  ? 668  LYS A CB  1 
ATOM   2907 C  CG  . LYS A 1 405 ? -0.336  -40.640 -37.875 1.00 25.69  ? 668  LYS A CG  1 
ATOM   2908 C  CD  . LYS A 1 405 ? -0.662  -41.947 -38.500 1.00 29.76  ? 668  LYS A CD  1 
ATOM   2909 C  CE  . LYS A 1 405 ? 0.575   -42.471 -39.217 1.00 32.80  ? 668  LYS A CE  1 
ATOM   2910 N  NZ  . LYS A 1 405 ? 0.360   -43.809 -39.788 1.00 34.21  ? 668  LYS A NZ  1 
ATOM   2911 N  N   . PRO A 1 406 ? 0.678   -36.950 -36.859 1.00 24.13  ? 669  PRO A N   1 
ATOM   2912 C  CA  . PRO A 1 406 ? 1.175   -35.825 -37.669 1.00 24.06  ? 669  PRO A CA  1 
ATOM   2913 C  C   . PRO A 1 406 ? 1.793   -36.289 -38.987 1.00 23.79  ? 669  PRO A C   1 
ATOM   2914 O  O   . PRO A 1 406 ? 2.044   -37.474 -39.208 1.00 23.21  ? 669  PRO A O   1 
ATOM   2915 C  CB  . PRO A 1 406 ? 2.164   -35.154 -36.724 1.00 23.21  ? 669  PRO A CB  1 
ATOM   2916 C  CG  . PRO A 1 406 ? 2.747   -36.317 -35.952 1.00 23.73  ? 669  PRO A CG  1 
ATOM   2917 C  CD  . PRO A 1 406 ? 1.540   -37.209 -35.697 1.00 21.88  ? 669  PRO A CD  1 
ATOM   2918 N  N   . LEU A 1 407 ? 2.085   -35.310 -39.854 1.00 26.71  ? 670  LEU A N   1 
ATOM   2919 C  CA  . LEU A 1 407 ? 2.707   -35.551 -41.182 1.00 29.82  ? 670  LEU A CA  1 
ATOM   2920 C  C   . LEU A 1 407 ? 4.044   -36.310 -41.015 1.00 26.80  ? 670  LEU A C   1 
ATOM   2921 O  O   . LEU A 1 407 ? 4.351   -37.161 -41.848 1.00 29.71  ? 670  LEU A O   1 
ATOM   2922 C  CB  . LEU A 1 407 ? 2.854   -34.177 -41.857 1.00 31.15  ? 670  LEU A CB  1 
ATOM   2923 C  CG  . LEU A 1 407 ? 3.051   -34.175 -43.367 1.00 39.07  ? 670  LEU A CG  1 
ATOM   2924 C  CD1 . LEU A 1 407 ? 1.771   -34.558 -44.090 1.00 40.01  ? 670  LEU A CD1 1 
ATOM   2925 C  CD2 . LEU A 1 407 ? 3.544   -32.806 -43.833 1.00 39.30  ? 670  LEU A CD2 1 
ATOM   2926 N  N   . ASP A 1 408 ? 4.784   -36.073 -39.947 1.00 26.82  ? 671  ASP A N   1 
ATOM   2927 C  CA  . ASP A 1 408 ? 6.089   -36.746 -39.712 1.00 30.37  ? 671  ASP A CA  1 
ATOM   2928 C  C   . ASP A 1 408 ? 6.452   -36.563 -38.249 1.00 27.55  ? 671  ASP A C   1 
ATOM   2929 O  O   . ASP A 1 408 ? 5.699   -35.908 -37.547 1.00 32.82  ? 671  ASP A O   1 
ATOM   2930 C  CB  . ASP A 1 408 ? 7.163   -36.228 -40.696 1.00 31.21  ? 671  ASP A CB  1 
ATOM   2931 C  CG  . ASP A 1 408 ? 7.257   -34.716 -40.695 1.00 27.68  ? 671  ASP A CG  1 
ATOM   2932 O  OD1 . ASP A 1 408 ? 7.520   -34.142 -39.610 1.00 28.09  ? 671  ASP A OD1 1 
ATOM   2933 O  OD2 . ASP A 1 408 ? 6.900   -34.104 -41.733 1.00 33.35  ? 671  ASP A OD2 1 
ATOM   2934 N  N   . ASP A 1 409 ? 7.630   -37.013 -37.808 1.00 26.30  ? 672  ASP A N   1 
ATOM   2935 C  CA  . ASP A 1 409 ? 7.970   -37.011 -36.364 1.00 25.73  ? 672  ASP A CA  1 
ATOM   2936 C  C   . ASP A 1 409 ? 8.645   -35.704 -35.907 1.00 25.85  ? 672  ASP A C   1 
ATOM   2937 O  O   . ASP A 1 409 ? 8.987   -35.600 -34.720 1.00 26.41  ? 672  ASP A O   1 
ATOM   2938 C  CB  . ASP A 1 409 ? 8.755   -38.280 -36.035 1.00 30.21  ? 672  ASP A CB  1 
ATOM   2939 C  CG  . ASP A 1 409 ? 7.900   -39.529 -36.144 1.00 34.69  ? 672  ASP A CG  1 
ATOM   2940 O  OD1 . ASP A 1 409 ? 6.774   -39.528 -35.552 1.00 31.35  ? 672  ASP A OD1 1 
ATOM   2941 O  OD2 . ASP A 1 409 ? 8.339   -40.465 -36.837 1.00 33.49  ? 672  ASP A OD2 1 
ATOM   2942 N  N   . ARG A 1 410 ? 8.722   -34.661 -36.739 1.00 28.26  ? 673  ARG A N   1 
ATOM   2943 C  CA  . ARG A 1 410 ? 9.170   -33.322 -36.244 1.00 29.25  ? 673  ARG A CA  1 
ATOM   2944 C  C   . ARG A 1 410 ? 8.261   -32.856 -35.112 1.00 27.67  ? 673  ARG A C   1 
ATOM   2945 O  O   . ARG A 1 410 ? 8.718   -32.166 -34.221 1.00 27.22  ? 673  ARG A O   1 
ATOM   2946 C  CB  . ARG A 1 410 ? 9.192   -32.280 -37.373 1.00 30.72  ? 673  ARG A CB  1 
ATOM   2947 C  CG  . ARG A 1 410 ? 10.291  -32.496 -38.408 1.00 32.12  ? 673  ARG A CG  1 
ATOM   2948 C  CD  . ARG A 1 410 ? 10.158  -31.488 -39.535 1.00 29.27  ? 673  ARG A CD  1 
ATOM   2949 N  NE  . ARG A 1 410 ? 8.972   -31.756 -40.335 1.00 29.11  ? 673  ARG A NE  1 
ATOM   2950 C  CZ  . ARG A 1 410 ? 8.449   -30.963 -41.265 1.00 32.74  ? 673  ARG A CZ  1 
ATOM   2951 N  NH1 . ARG A 1 410 ? 8.991   -29.779 -41.546 1.00 32.03  ? 673  ARG A NH1 1 
ATOM   2952 N  NH2 . ARG A 1 410 ? 7.357   -31.360 -41.901 1.00 31.30  ? 673  ARG A NH2 1 
ATOM   2953 N  N   . PHE A 1 411 ? 6.973   -33.237 -35.154 1.00 27.01  ? 674  PHE A N   1 
ATOM   2954 C  CA  . PHE A 1 411 ? 5.952   -32.993 -34.110 1.00 24.44  ? 674  PHE A CA  1 
ATOM   2955 C  C   . PHE A 1 411 ? 6.457   -33.351 -32.711 1.00 22.64  ? 674  PHE A C   1 
ATOM   2956 O  O   . PHE A 1 411 ? 6.161   -32.567 -31.794 1.00 25.92  ? 674  PHE A O   1 
ATOM   2957 C  CB  . PHE A 1 411 ? 4.699   -33.801 -34.492 1.00 24.59  ? 674  PHE A CB  1 
ATOM   2958 C  CG  . PHE A 1 411 ? 3.516   -33.656 -33.563 1.00 25.24  ? 674  PHE A CG  1 
ATOM   2959 C  CD1 . PHE A 1 411 ? 3.367   -34.479 -32.450 1.00 24.45  ? 674  PHE A CD1 1 
ATOM   2960 C  CD2 . PHE A 1 411 ? 2.505   -32.755 -33.861 1.00 25.26  ? 674  PHE A CD2 1 
ATOM   2961 C  CE1 . PHE A 1 411 ? 2.241   -34.362 -31.636 1.00 25.59  ? 674  PHE A CE1 1 
ATOM   2962 C  CE2 . PHE A 1 411 ? 1.379   -32.645 -33.047 1.00 24.64  ? 674  PHE A CE2 1 
ATOM   2963 C  CZ  . PHE A 1 411 ? 1.261   -33.431 -31.925 1.00 25.23  ? 674  PHE A CZ  1 
ATOM   2964 N  N   . ALA A 1 412 ? 7.219   -34.448 -32.544 1.00 25.02  ? 675  ALA A N   1 
ATOM   2965 C  CA  . ALA A 1 412 ? 7.702   -34.956 -31.242 1.00 27.39  ? 675  ALA A CA  1 
ATOM   2966 C  C   . ALA A 1 412 ? 8.460   -33.866 -30.470 1.00 29.06  ? 675  ALA A C   1 
ATOM   2967 O  O   . ALA A 1 412 ? 8.282   -33.758 -29.235 1.00 26.59  ? 675  ALA A O   1 
ATOM   2968 C  CB  . ALA A 1 412 ? 8.577   -36.184 -31.439 1.00 28.26  ? 675  ALA A CB  1 
ATOM   2969 N  N   . SER A 1 413 ? 9.259   -33.048 -31.167 1.00 29.42  ? 676  SER A N   1 
ATOM   2970 C  CA  . SER A 1 413 ? 10.091  -32.020 -30.495 1.00 29.45  ? 676  SER A CA  1 
ATOM   2971 C  C   . SER A 1 413 ? 9.573   -30.614 -30.793 1.00 34.88  ? 676  SER A C   1 
ATOM   2972 O  O   . SER A 1 413 ? 10.303  -29.656 -30.488 1.00 34.78  ? 676  SER A O   1 
ATOM   2973 C  CB  . SER A 1 413 ? 11.585  -32.170 -30.844 1.00 33.09  ? 676  SER A CB  1 
ATOM   2974 O  OG  . SER A 1 413 ? 11.747  -32.239 -32.251 1.00 35.44  ? 676  SER A OG  1 
ATOM   2975 N  N   . ALA A 1 414 ? 8.339   -30.471 -31.303 1.00 32.67  ? 677  ALA A N   1 
ATOM   2976 C  CA  . ALA A 1 414 ? 7.702   -29.159 -31.555 1.00 31.39  ? 677  ALA A CA  1 
ATOM   2977 C  C   . ALA A 1 414 ? 6.952   -28.769 -30.280 1.00 33.09  ? 677  ALA A C   1 
ATOM   2978 O  O   . ALA A 1 414 ? 5.751   -29.146 -30.137 1.00 32.08  ? 677  ALA A O   1 
ATOM   2979 C  CB  . ALA A 1 414 ? 6.821   -29.249 -32.766 1.00 31.93  ? 677  ALA A CB  1 
ATOM   2980 N  N   . LEU A 1 415 ? 7.616   -28.113 -29.327 1.00 30.00  ? 678  LEU A N   1 
ATOM   2981 C  CA  . LEU A 1 415 ? 7.094   -27.968 -27.945 1.00 29.85  ? 678  LEU A CA  1 
ATOM   2982 C  C   . LEU A 1 415 ? 6.935   -26.497 -27.526 1.00 29.15  ? 678  LEU A C   1 
ATOM   2983 O  O   . LEU A 1 415 ? 6.353   -26.276 -26.462 1.00 32.10  ? 678  LEU A O   1 
ATOM   2984 C  CB  . LEU A 1 415 ? 7.997   -28.726 -26.979 1.00 30.37  ? 678  LEU A CB  1 
ATOM   2985 C  CG  . LEU A 1 415 ? 8.132   -30.241 -27.219 1.00 31.60  ? 678  LEU A CG  1 
ATOM   2986 C  CD1 . LEU A 1 415 ? 9.288   -30.811 -26.418 1.00 35.24  ? 678  LEU A CD1 1 
ATOM   2987 C  CD2 . LEU A 1 415 ? 6.850   -30.970 -26.848 1.00 30.28  ? 678  LEU A CD2 1 
ATOM   2988 N  N   . THR A 1 416 ? 7.404   -25.522 -28.299 1.00 30.54  ? 679  THR A N   1 
ATOM   2989 C  CA  . THR A 1 416 ? 7.456   -24.116 -27.806 1.00 30.99  ? 679  THR A CA  1 
ATOM   2990 C  C   . THR A 1 416 ? 6.034   -23.562 -27.664 1.00 29.36  ? 679  THR A C   1 
ATOM   2991 O  O   . THR A 1 416 ? 5.720   -23.059 -26.563 1.00 31.32  ? 679  THR A O   1 
ATOM   2992 C  CB  . THR A 1 416 ? 8.381   -23.233 -28.651 1.00 31.13  ? 679  THR A CB  1 
ATOM   2993 O  OG1 . THR A 1 416 ? 7.905   -23.046 -29.987 1.00 35.33  ? 679  THR A OG1 1 
ATOM   2994 C  CG2 . THR A 1 416 ? 9.780   -23.808 -28.711 1.00 36.18  ? 679  THR A CG2 1 
ATOM   2995 N  N   . ALA A 1 417 ? 5.191   -23.707 -28.684 1.00 33.02  ? 680  ALA A N   1 
ATOM   2996 C  CA  . ALA A 1 417 ? 3.789   -23.216 -28.633 1.00 31.57  ? 680  ALA A CA  1 
ATOM   2997 C  C   . ALA A 1 417 ? 3.029   -23.999 -27.545 1.00 33.60  ? 680  ALA A C   1 
ATOM   2998 O  O   . ALA A 1 417 ? 2.365   -23.338 -26.697 1.00 32.63  ? 680  ALA A O   1 
ATOM   2999 C  CB  . ALA A 1 417 ? 3.157   -23.280 -29.997 1.00 33.65  ? 680  ALA A CB  1 
ATOM   3000 N  N   . LEU A 1 418 ? 3.155   -25.344 -27.499 1.00 31.71  ? 681  LEU A N   1 
ATOM   3001 C  CA  . LEU A 1 418 ? 2.381   -26.175 -26.537 1.00 29.58  ? 681  LEU A CA  1 
ATOM   3002 C  C   . LEU A 1 418 ? 2.693   -25.736 -25.113 1.00 27.94  ? 681  LEU A C   1 
ATOM   3003 O  O   . LEU A 1 418 ? 1.775   -25.528 -24.318 1.00 28.22  ? 681  LEU A O   1 
ATOM   3004 C  CB  . LEU A 1 418 ? 2.710   -27.656 -26.772 1.00 28.73  ? 681  LEU A CB  1 
ATOM   3005 C  CG  . LEU A 1 418 ? 1.862   -28.648 -26.000 1.00 31.18  ? 681  LEU A CG  1 
ATOM   3006 C  CD1 . LEU A 1 418 ? 0.492   -28.793 -26.638 1.00 32.25  ? 681  LEU A CD1 1 
ATOM   3007 C  CD2 . LEU A 1 418 ? 2.554   -29.997 -25.929 1.00 29.54  ? 681  LEU A CD2 1 
ATOM   3008 N  N   . ASN A 1 419 ? 3.979   -25.528 -24.803 1.00 31.12  ? 682  ASN A N   1 
ATOM   3009 C  CA  . ASN A 1 419 ? 4.403   -25.119 -23.448 1.00 30.42  ? 682  ASN A CA  1 
ATOM   3010 C  C   . ASN A 1 419 ? 3.950   -23.677 -23.210 1.00 29.29  ? 682  ASN A C   1 
ATOM   3011 O  O   . ASN A 1 419 ? 3.454   -23.406 -22.128 1.00 33.21  ? 682  ASN A O   1 
ATOM   3012 C  CB  . ASN A 1 419 ? 5.910   -25.344 -23.263 1.00 34.41  ? 682  ASN A CB  1 
ATOM   3013 C  CG  . ASN A 1 419 ? 6.254   -26.794 -22.937 1.00 35.85  ? 682  ASN A CG  1 
ATOM   3014 O  OD1 . ASN A 1 419 ? 5.448   -27.538 -22.374 1.00 34.98  ? 682  ASN A OD1 1 
ATOM   3015 N  ND2 . ASN A 1 419 ? 7.466   -27.204 -23.255 1.00 34.20  ? 682  ASN A ND2 1 
ATOM   3016 N  N   . ASP A 1 420 ? 4.081   -22.799 -24.194 1.00 32.05  ? 683  ASP A N   1 
ATOM   3017 C  CA  . ASP A 1 420 ? 3.763   -21.355 -24.010 1.00 34.36  ? 683  ASP A CA  1 
ATOM   3018 C  C   . ASP A 1 420 ? 2.238   -21.144 -23.896 1.00 37.43  ? 683  ASP A C   1 
ATOM   3019 O  O   . ASP A 1 420 ? 1.832   -20.201 -23.223 1.00 36.94  ? 683  ASP A O   1 
ATOM   3020 C  CB  . ASP A 1 420 ? 4.322   -20.491 -25.135 1.00 35.33  ? 683  ASP A CB  1 
ATOM   3021 C  CG  . ASP A 1 420 ? 4.274   -19.004 -24.777 1.00 38.26  ? 683  ASP A CG  1 
ATOM   3022 O  OD1 . ASP A 1 420 ? 4.660   -18.681 -23.641 1.00 36.15  ? 683  ASP A OD1 1 
ATOM   3023 O  OD2 . ASP A 1 420 ? 3.784   -18.205 -25.615 1.00 39.15  ? 683  ASP A OD2 1 
ATOM   3024 N  N   . MET A 1 421 ? 1.413   -22.011 -24.487 1.00 36.19  ? 684  MET A N   1 
ATOM   3025 C  CA  . MET A 1 421 ? -0.066  -21.947 -24.314 1.00 33.38  ? 684  MET A CA  1 
ATOM   3026 C  C   . MET A 1 421 ? -0.442  -22.462 -22.919 1.00 33.57  ? 684  MET A C   1 
ATOM   3027 O  O   . MET A 1 421 ? -1.605  -22.347 -22.553 1.00 35.01  ? 684  MET A O   1 
ATOM   3028 C  CB  . MET A 1 421 ? -0.812  -22.728 -25.405 1.00 33.89  ? 684  MET A CB  1 
ATOM   3029 C  CG  . MET A 1 421 ? -0.621  -22.181 -26.795 1.00 34.96  ? 684  MET A CG  1 
ATOM   3030 S  SD  . MET A 1 421 ? -1.568  -23.106 -28.113 1.00 37.44  ? 684  MET A SD  1 
ATOM   3031 C  CE  . MET A 1 421 ? -0.676  -24.657 -28.194 1.00 39.58  ? 684  MET A CE  1 
ATOM   3032 N  N   . GLY A 1 422 ? 0.510   -23.006 -22.148 1.00 32.86  ? 685  GLY A N   1 
ATOM   3033 C  CA  . GLY A 1 422 ? 0.292   -23.569 -20.803 1.00 28.65  ? 685  GLY A CA  1 
ATOM   3034 C  C   . GLY A 1 422 ? -0.101  -25.041 -20.806 1.00 28.67  ? 685  GLY A C   1 
ATOM   3035 O  O   . GLY A 1 422 ? -0.341  -25.588 -19.713 1.00 31.83  ? 685  GLY A O   1 
ATOM   3036 N  N   . LYS A 1 423 ? -0.149  -25.699 -21.963 1.00 29.63  ? 686  LYS A N   1 
ATOM   3037 C  CA  . LYS A 1 423 ? -0.594  -27.126 -22.061 1.00 31.83  ? 686  LYS A CA  1 
ATOM   3038 C  C   . LYS A 1 423 ? 0.599   -28.081 -21.853 1.00 30.16  ? 686  LYS A C   1 
ATOM   3039 O  O   . LYS A 1 423 ? 0.932   -28.899 -22.760 1.00 30.29  ? 686  LYS A O   1 
ATOM   3040 C  CB  . LYS A 1 423 ? -1.363  -27.312 -23.373 1.00 30.26  ? 686  LYS A CB  1 
ATOM   3041 C  CG  . LYS A 1 423 ? -2.507  -26.316 -23.545 1.00 30.89  ? 686  LYS A CG  1 
ATOM   3042 C  CD  . LYS A 1 423 ? -3.433  -26.274 -22.345 1.00 31.88  ? 686  LYS A CD  1 
ATOM   3043 C  CE  . LYS A 1 423 ? -4.628  -25.346 -22.493 1.00 37.10  ? 686  LYS A CE  1 
ATOM   3044 N  NZ  . LYS A 1 423 ? -4.211  -23.925 -22.335 1.00 39.31  ? 686  LYS A NZ  1 
ATOM   3045 N  N   . VAL A 1 424 ? 1.189   -27.994 -20.660 1.00 33.48  ? 687  VAL A N   1 
ATOM   3046 C  CA  . VAL A 1 424 ? 2.416   -28.739 -20.251 1.00 33.47  ? 687  VAL A CA  1 
ATOM   3047 C  C   . VAL A 1 424 ? 2.040   -30.214 -20.120 1.00 29.95  ? 687  VAL A C   1 
ATOM   3048 O  O   . VAL A 1 424 ? 0.992   -30.552 -19.464 1.00 32.37  ? 687  VAL A O   1 
ATOM   3049 C  CB  . VAL A 1 424 ? 3.038   -28.153 -18.960 1.00 38.73  ? 687  VAL A CB  1 
ATOM   3050 C  CG1 . VAL A 1 424 ? 4.083   -29.071 -18.337 1.00 45.61  ? 687  VAL A CG1 1 
ATOM   3051 C  CG2 . VAL A 1 424 ? 3.652   -26.785 -19.224 1.00 41.07  ? 687  VAL A CG2 1 
ATOM   3052 N  N   . ARG A 1 425 ? 2.852   -31.077 -20.731 0.50 30.35  ? 688  ARG A N   1 
ATOM   3053 C  CA  . ARG A 1 425 ? 2.623   -32.538 -20.793 0.50 32.19  ? 688  ARG A CA  1 
ATOM   3054 C  C   . ARG A 1 425 ? 2.791   -33.125 -19.394 0.50 33.83  ? 688  ARG A C   1 
ATOM   3055 O  O   . ARG A 1 425 ? 3.533   -32.528 -18.581 0.50 35.73  ? 688  ARG A O   1 
ATOM   3056 C  CB  . ARG A 1 425 ? 3.564   -33.174 -21.818 0.50 31.48  ? 688  ARG A CB  1 
ATOM   3057 C  CG  . ARG A 1 425 ? 3.270   -32.748 -23.247 0.50 31.10  ? 688  ARG A CG  1 
ATOM   3058 C  CD  . ARG A 1 425 ? 4.408   -33.069 -24.189 0.50 30.84  ? 688  ARG A CD  1 
ATOM   3059 N  NE  . ARG A 1 425 ? 5.636   -32.411 -23.773 0.50 31.36  ? 688  ARG A NE  1 
ATOM   3060 C  CZ  . ARG A 1 425 ? 6.859   -32.782 -24.139 0.50 31.31  ? 688  ARG A CZ  1 
ATOM   3061 N  NH1 . ARG A 1 425 ? 7.032   -33.814 -24.948 0.50 29.87  ? 688  ARG A NH1 1 
ATOM   3062 N  NH2 . ARG A 1 425 ? 7.905   -32.107 -23.691 0.50 30.91  ? 688  ARG A NH2 1 
ATOM   3063 N  N   . LYS A 1 426 ? 2.090   -34.229 -19.136 0.50 34.32  ? 689  LYS A N   1 
ATOM   3064 C  CA  . LYS A 1 426 ? 2.207   -35.065 -17.916 0.50 36.96  ? 689  LYS A CA  1 
ATOM   3065 C  C   . LYS A 1 426 ? 3.459   -35.950 -18.039 0.50 38.17  ? 689  LYS A C   1 
ATOM   3066 O  O   . LYS A 1 426 ? 3.881   -36.227 -19.176 0.50 37.64  ? 689  LYS A O   1 
ATOM   3067 C  CB  . LYS A 1 426 ? 0.932   -35.903 -17.771 0.50 37.91  ? 689  LYS A CB  1 
ATOM   3068 C  CG  . LYS A 1 426 ? 0.674   -36.495 -16.393 0.50 40.54  ? 689  LYS A CG  1 
ATOM   3069 C  CD  . LYS A 1 426 ? -0.648  -37.220 -16.310 0.50 42.76  ? 689  LYS A CD  1 
ATOM   3070 C  CE  . LYS A 1 426 ? -0.802  -38.261 -17.399 0.50 45.74  ? 689  LYS A CE  1 
ATOM   3071 N  NZ  . LYS A 1 426 ? -2.203  -38.724 -17.544 0.50 46.20  ? 689  LYS A NZ  1 
ATOM   3072 N  N   . ASP A 1 427 ? 4.056   -36.326 -16.905 0.50 42.24  ? 690  ASP A N   1 
ATOM   3073 C  CA  . ASP A 1 427 ? 5.014   -37.460 -16.770 0.50 42.14  ? 690  ASP A CA  1 
ATOM   3074 C  C   . ASP A 1 427 ? 6.176   -37.359 -17.776 0.50 43.30  ? 690  ASP A C   1 
ATOM   3075 O  O   . ASP A 1 427 ? 6.607   -38.436 -18.249 0.50 44.80  ? 690  ASP A O   1 
ATOM   3076 C  CB  . ASP A 1 427 ? 4.283   -38.795 -16.961 0.50 43.09  ? 690  ASP A CB  1 
ATOM   3077 C  CG  . ASP A 1 427 ? 3.141   -39.028 -15.981 0.50 44.36  ? 690  ASP A CG  1 
ATOM   3078 O  OD1 . ASP A 1 427 ? 3.106   -38.321 -14.951 0.50 46.94  ? 690  ASP A OD1 1 
ATOM   3079 O  OD2 . ASP A 1 427 ? 2.286   -39.909 -16.258 0.50 41.73  ? 690  ASP A OD2 1 
ATOM   3080 N  N   . ILE A 1 428 ? 6.689   -36.156 -18.087 1.00 40.70  ? 691  ILE A N   1 
ATOM   3081 C  CA  . ILE A 1 428 ? 7.834   -36.000 -19.028 1.00 42.58  ? 691  ILE A CA  1 
ATOM   3082 C  C   . ILE A 1 428 ? 8.410   -34.617 -18.732 1.00 44.11  ? 691  ILE A C   1 
ATOM   3083 O  O   . ILE A 1 428 ? 7.659   -33.740 -18.299 1.00 42.77  ? 691  ILE A O   1 
ATOM   3084 C  CB  . ILE A 1 428 ? 7.424   -36.187 -20.512 1.00 39.83  ? 691  ILE A CB  1 
ATOM   3085 C  CG1 . ILE A 1 428 ? 8.657   -36.331 -21.393 1.00 40.30  ? 691  ILE A CG1 1 
ATOM   3086 C  CG2 . ILE A 1 428 ? 6.502   -35.070 -21.010 1.00 36.70  ? 691  ILE A CG2 1 
ATOM   3087 C  CD1 . ILE A 1 428 ? 8.389   -36.936 -22.737 1.00 38.80  ? 691  ILE A CD1 1 
ATOM   3088 N  N   . GLN A 1 429 ? 9.719   -34.444 -18.943 0.50 43.70  ? 692  GLN A N   1 
ATOM   3089 C  CA  . GLN A 1 429 ? 10.446  -33.165 -18.718 0.50 44.74  ? 692  GLN A CA  1 
ATOM   3090 C  C   . GLN A 1 429 ? 10.056  -32.167 -19.817 0.50 42.58  ? 692  GLN A C   1 
ATOM   3091 O  O   . GLN A 1 429 ? 9.916   -32.583 -20.986 0.50 38.25  ? 692  GLN A O   1 
ATOM   3092 C  CB  . GLN A 1 429 ? 11.956  -33.418 -18.679 0.50 49.57  ? 692  GLN A CB  1 
ATOM   3093 C  CG  . GLN A 1 429 ? 12.370  -34.459 -17.642 0.50 52.10  ? 692  GLN A CG  1 
ATOM   3094 C  CD  . GLN A 1 429 ? 13.703  -35.106 -17.939 0.50 55.87  ? 692  GLN A CD  1 
ATOM   3095 O  OE1 . GLN A 1 429 ? 13.867  -35.828 -18.923 0.50 54.38  ? 692  GLN A OE1 1 
ATOM   3096 N  NE2 . GLN A 1 429 ? 14.673  -34.863 -17.071 0.50 59.91  ? 692  GLN A NE2 1 
ATOM   3097 N  N   . GLN A 1 430 ? 9.918   -30.891 -19.447 0.50 44.55  ? 693  GLN A N   1 
ATOM   3098 C  CA  . GLN A 1 430 ? 9.303   -29.819 -20.274 0.50 45.32  ? 693  GLN A CA  1 
ATOM   3099 C  C   . GLN A 1 430 ? 9.804   -29.885 -21.722 0.50 44.85  ? 693  GLN A C   1 
ATOM   3100 O  O   . GLN A 1 430 ? 8.969   -29.709 -22.635 0.50 42.32  ? 693  GLN A O   1 
ATOM   3101 C  CB  . GLN A 1 430 ? 9.600   -28.444 -19.671 0.50 48.94  ? 693  GLN A CB  1 
ATOM   3102 C  CG  . GLN A 1 430 ? 8.402   -27.505 -19.709 0.50 52.02  ? 693  GLN A CG  1 
ATOM   3103 C  CD  . GLN A 1 430 ? 8.795   -26.047 -19.695 0.50 52.11  ? 693  GLN A CD  1 
ATOM   3104 O  OE1 . GLN A 1 430 ? 9.940   -25.693 -19.414 0.50 51.33  ? 693  GLN A OE1 1 
ATOM   3105 N  NE2 . GLN A 1 430 ? 7.835   -25.189 -20.002 0.50 50.13  ? 693  GLN A NE2 1 
ATOM   3106 N  N   . TRP A 1 431 ? 11.109  -30.101 -21.930 1.00 40.15  ? 694  TRP A N   1 
ATOM   3107 C  CA  . TRP A 1 431 ? 11.738  -29.991 -23.271 1.00 40.36  ? 694  TRP A CA  1 
ATOM   3108 C  C   . TRP A 1 431 ? 12.144  -31.348 -23.856 1.00 34.75  ? 694  TRP A C   1 
ATOM   3109 O  O   . TRP A 1 431 ? 12.682  -31.351 -24.970 1.00 36.36  ? 694  TRP A O   1 
ATOM   3110 C  CB  . TRP A 1 431 ? 12.895  -28.986 -23.172 1.00 44.73  ? 694  TRP A CB  1 
ATOM   3111 C  CG  . TRP A 1 431 ? 12.405  -27.623 -22.771 1.00 50.75  ? 694  TRP A CG  1 
ATOM   3112 C  CD1 . TRP A 1 431 ? 12.640  -26.963 -21.598 1.00 48.32  ? 694  TRP A CD1 1 
ATOM   3113 C  CD2 . TRP A 1 431 ? 11.505  -26.784 -23.529 1.00 47.07  ? 694  TRP A CD2 1 
ATOM   3114 N  NE1 . TRP A 1 431 ? 11.973  -25.767 -21.584 1.00 51.10  ? 694  TRP A NE1 1 
ATOM   3115 C  CE2 . TRP A 1 431 ? 11.278  -25.621 -22.759 1.00 50.34  ? 694  TRP A CE2 1 
ATOM   3116 C  CE3 . TRP A 1 431 ? 10.907  -26.886 -24.792 1.00 43.67  ? 694  TRP A CE3 1 
ATOM   3117 C  CZ2 . TRP A 1 431 ? 10.444  -24.589 -23.197 1.00 47.85  ? 694  TRP A CZ2 1 
ATOM   3118 C  CZ3 . TRP A 1 431 ? 10.104  -25.853 -25.234 1.00 46.50  ? 694  TRP A CZ3 1 
ATOM   3119 C  CH2 . TRP A 1 431 ? 9.859   -24.733 -24.437 1.00 44.31  ? 694  TRP A CH2 1 
ATOM   3120 N  N   . GLU A 1 432 ? 11.820  -32.459 -23.198 1.00 34.55  ? 695  GLU A N   1 
ATOM   3121 C  CA  . GLU A 1 432 ? 12.108  -33.815 -23.739 1.00 37.76  ? 695  GLU A CA  1 
ATOM   3122 C  C   . GLU A 1 432 ? 11.075  -34.094 -24.839 1.00 37.68  ? 695  GLU A C   1 
ATOM   3123 O  O   . GLU A 1 432 ? 9.871   -33.868 -24.661 1.00 33.97  ? 695  GLU A O   1 
ATOM   3124 C  CB  . GLU A 1 432 ? 12.116  -34.806 -22.569 1.00 41.93  ? 695  GLU A CB  1 
ATOM   3125 C  CG  . GLU A 1 432 ? 12.494  -36.229 -22.923 1.00 57.00  ? 695  GLU A CG  1 
ATOM   3126 C  CD  . GLU A 1 432 ? 13.945  -36.457 -23.347 1.00 67.87  ? 695  GLU A CD  1 
ATOM   3127 O  OE1 . GLU A 1 432 ? 14.236  -37.588 -23.802 1.00 66.51  ? 695  GLU A OE1 1 
ATOM   3128 O  OE2 . GLU A 1 432 ? 14.782  -35.504 -23.253 1.00 68.38  ? 695  GLU A OE2 1 
ATOM   3129 N  N   . PRO A 1 433 ? 11.520  -34.591 -26.001 1.00 35.67  ? 696  PRO A N   1 
ATOM   3130 C  CA  . PRO A 1 433 ? 10.619  -34.920 -27.104 1.00 31.18  ? 696  PRO A CA  1 
ATOM   3131 C  C   . PRO A 1 433 ? 9.605   -35.982 -26.674 1.00 30.08  ? 696  PRO A C   1 
ATOM   3132 O  O   . PRO A 1 433 ? 9.915   -36.854 -25.930 1.00 27.63  ? 696  PRO A O   1 
ATOM   3133 C  CB  . PRO A 1 433 ? 11.522  -35.483 -28.201 1.00 37.23  ? 696  PRO A CB  1 
ATOM   3134 C  CG  . PRO A 1 433 ? 12.934  -34.987 -27.807 1.00 40.32  ? 696  PRO A CG  1 
ATOM   3135 C  CD  . PRO A 1 433 ? 12.923  -34.966 -26.296 1.00 34.00  ? 696  PRO A CD  1 
ATOM   3136 N  N   . SER A 1 434 ? 8.368   -35.868 -27.165 0.50 28.07  ? 697  SER A N   1 
ATOM   3137 C  CA  . SER A 1 434 ? 7.278   -36.835 -26.885 0.50 27.90  ? 697  SER A CA  1 
ATOM   3138 C  C   . SER A 1 434 ? 7.655   -38.238 -27.380 0.50 27.67  ? 697  SER A C   1 
ATOM   3139 O  O   . SER A 1 434 ? 8.286   -38.349 -28.438 0.50 30.94  ? 697  SER A O   1 
ATOM   3140 C  CB  . SER A 1 434 ? 5.986   -36.362 -27.498 0.50 25.97  ? 697  SER A CB  1 
ATOM   3141 O  OG  . SER A 1 434 ? 5.465   -35.268 -26.765 0.50 24.85  ? 697  SER A OG  1 
ATOM   3142 N  N   . ARG A 1 435 ? 7.269   -39.273 -26.629 0.50 30.18  ? 698  ARG A N   1 
ATOM   3143 C  CA  . ARG A 1 435 ? 7.350   -40.697 -27.054 0.50 33.47  ? 698  ARG A CA  1 
ATOM   3144 C  C   . ARG A 1 435 ? 6.076   -41.046 -27.840 0.50 32.09  ? 698  ARG A C   1 
ATOM   3145 O  O   . ARG A 1 435 ? 4.992   -40.965 -27.238 0.50 33.60  ? 698  ARG A O   1 
ATOM   3146 C  CB  . ARG A 1 435 ? 7.479   -41.594 -25.818 0.50 35.93  ? 698  ARG A CB  1 
ATOM   3147 C  CG  . ARG A 1 435 ? 8.630   -41.210 -24.897 0.50 39.20  ? 698  ARG A CG  1 
ATOM   3148 C  CD  . ARG A 1 435 ? 8.656   -42.042 -23.629 0.50 41.47  ? 698  ARG A CD  1 
ATOM   3149 N  NE  . ARG A 1 435 ? 7.570   -41.675 -22.735 0.50 43.19  ? 698  ARG A NE  1 
ATOM   3150 C  CZ  . ARG A 1 435 ? 7.695   -40.896 -21.669 0.50 44.25  ? 698  ARG A CZ  1 
ATOM   3151 N  NH1 . ARG A 1 435 ? 8.877   -40.406 -21.337 0.50 45.69  ? 698  ARG A NH1 1 
ATOM   3152 N  NH2 . ARG A 1 435 ? 6.636   -40.617 -20.933 0.50 44.31  ? 698  ARG A NH2 1 
ATOM   3153 N  N   . GLY A 1 436 ? 6.194   -41.424 -29.114 1.00 30.32  ? 699  GLY A N   1 
ATOM   3154 C  CA  . GLY A 1 436 ? 5.034   -41.806 -29.927 1.00 34.19  ? 699  GLY A CA  1 
ATOM   3155 C  C   . GLY A 1 436 ? 4.791   -43.308 -29.892 1.00 32.52  ? 699  GLY A C   1 
ATOM   3156 O  O   . GLY A 1 436 ? 5.626   -44.040 -29.384 1.00 33.72  ? 699  GLY A O   1 
ATOM   3157 N  N   . TRP A 1 437 ? 3.676   -43.747 -30.463 1.00 27.12  ? 700  TRP A N   1 
ATOM   3158 C  CA  . TRP A 1 437 ? 3.287   -45.165 -30.541 1.00 25.92  ? 700  TRP A CA  1 
ATOM   3159 C  C   . TRP A 1 437 ? 3.393   -45.604 -31.991 1.00 29.54  ? 700  TRP A C   1 
ATOM   3160 O  O   . TRP A 1 437 ? 2.917   -44.867 -32.875 1.00 28.66  ? 700  TRP A O   1 
ATOM   3161 C  CB  . TRP A 1 437 ? 1.872   -45.339 -29.975 1.00 24.55  ? 700  TRP A CB  1 
ATOM   3162 C  CG  . TRP A 1 437 ? 1.736   -44.884 -28.564 1.00 24.17  ? 700  TRP A CG  1 
ATOM   3163 C  CD1 . TRP A 1 437 ? 1.439   -43.634 -28.115 1.00 27.21  ? 700  TRP A CD1 1 
ATOM   3164 C  CD2 . TRP A 1 437 ? 1.915   -45.699 -27.389 1.00 24.47  ? 700  TRP A CD2 1 
ATOM   3165 N  NE1 . TRP A 1 437 ? 1.423   -43.609 -26.747 1.00 28.08  ? 700  TRP A NE1 1 
ATOM   3166 C  CE2 . TRP A 1 437 ? 1.700   -44.869 -26.278 1.00 24.93  ? 700  TRP A CE2 1 
ATOM   3167 C  CE3 . TRP A 1 437 ? 2.220   -47.040 -27.200 1.00 26.17  ? 700  TRP A CE3 1 
ATOM   3168 C  CZ2 . TRP A 1 437 ? 1.728   -45.348 -24.971 1.00 27.87  ? 700  TRP A CZ2 1 
ATOM   3169 C  CZ3 . TRP A 1 437 ? 2.293   -47.511 -25.913 1.00 27.58  ? 700  TRP A CZ3 1 
ATOM   3170 C  CH2 . TRP A 1 437 ? 2.014   -46.684 -24.822 1.00 28.11  ? 700  TRP A CH2 1 
ATOM   3171 N  N   . ASN A 1 438 ? 4.002   -46.766 -32.229 1.00 28.64  ? 701  ASN A N   1 
ATOM   3172 C  CA  . ASN A 1 438 ? 4.167   -47.301 -33.592 1.00 31.22  ? 701  ASN A CA  1 
ATOM   3173 C  C   . ASN A 1 438 ? 2.972   -48.135 -34.015 1.00 32.89  ? 701  ASN A C   1 
ATOM   3174 O  O   . ASN A 1 438 ? 2.904   -48.455 -35.188 1.00 35.72  ? 701  ASN A O   1 
ATOM   3175 C  CB  . ASN A 1 438 ? 5.434   -48.168 -33.688 1.00 37.34  ? 701  ASN A CB  1 
ATOM   3176 C  CG  . ASN A 1 438 ? 6.673   -47.358 -33.361 1.00 48.02  ? 701  ASN A CG  1 
ATOM   3177 O  OD1 . ASN A 1 438 ? 7.482   -47.736 -32.500 1.00 52.03  ? 701  ASN A OD1 1 
ATOM   3178 N  ND2 . ASN A 1 438 ? 6.785   -46.210 -34.012 1.00 40.96  ? 701  ASN A ND2 1 
ATOM   3179 N  N   . ASP A 1 439 ? 2.062   -48.498 -33.114 1.00 30.92  ? 702  ASP A N   1 
ATOM   3180 C  CA  . ASP A 1 439 ? 0.974   -49.457 -33.461 1.00 32.93  ? 702  ASP A CA  1 
ATOM   3181 C  C   . ASP A 1 439 ? -0.305  -48.923 -32.825 1.00 28.75  ? 702  ASP A C   1 
ATOM   3182 O  O   . ASP A 1 439 ? -0.288  -48.728 -31.599 1.00 27.87  ? 702  ASP A O   1 
ATOM   3183 C  CB  . ASP A 1 439 ? 1.438   -50.840 -33.012 1.00 37.67  ? 702  ASP A CB  1 
ATOM   3184 C  CG  . ASP A 1 439 ? 0.431   -51.970 -32.938 1.00 42.10  ? 702  ASP A CG  1 
ATOM   3185 O  OD1 . ASP A 1 439 ? -0.738  -51.798 -33.442 1.00 40.46  ? 702  ASP A OD1 1 
ATOM   3186 O  OD2 . ASP A 1 439 ? 0.837   -53.034 -32.343 1.00 48.68  ? 702  ASP A OD2 1 
ATOM   3187 N  N   . TRP A 1 440 ? -1.329  -48.671 -33.637 1.00 27.84  ? 703  TRP A N   1 
ATOM   3188 C  CA  . TRP A 1 440 ? -2.614  -48.077 -33.189 1.00 25.42  ? 703  TRP A CA  1 
ATOM   3189 C  C   . TRP A 1 440 ? -3.241  -48.928 -32.070 1.00 25.93  ? 703  TRP A C   1 
ATOM   3190 O  O   . TRP A 1 440 ? -4.008  -48.375 -31.236 1.00 24.36  ? 703  TRP A O   1 
ATOM   3191 C  CB  . TRP A 1 440 ? -3.549  -47.857 -34.377 1.00 27.19  ? 703  TRP A CB  1 
ATOM   3192 C  CG  . TRP A 1 440 ? -4.093  -49.100 -35.014 1.00 28.45  ? 703  TRP A CG  1 
ATOM   3193 C  CD1 . TRP A 1 440 ? -3.581  -49.756 -36.098 1.00 30.09  ? 703  TRP A CD1 1 
ATOM   3194 C  CD2 . TRP A 1 440 ? -5.232  -49.866 -34.610 1.00 26.82  ? 703  TRP A CD2 1 
ATOM   3195 N  NE1 . TRP A 1 440 ? -4.361  -50.828 -36.442 1.00 27.61  ? 703  TRP A NE1 1 
ATOM   3196 C  CE2 . TRP A 1 440 ? -5.351  -50.956 -35.514 1.00 25.33  ? 703  TRP A CE2 1 
ATOM   3197 C  CE3 . TRP A 1 440 ? -6.208  -49.712 -33.624 1.00 26.15  ? 703  TRP A CE3 1 
ATOM   3198 C  CZ2 . TRP A 1 440 ? -6.345  -51.924 -35.419 1.00 26.33  ? 703  TRP A CZ2 1 
ATOM   3199 C  CZ3 . TRP A 1 440 ? -7.197  -50.659 -33.544 1.00 25.79  ? 703  TRP A CZ3 1 
ATOM   3200 C  CH2 . TRP A 1 440 ? -7.280  -51.739 -34.431 1.00 27.53  ? 703  TRP A CH2 1 
ATOM   3201 N  N   . THR A 1 441 ? -2.940  -50.217 -32.031 1.00 23.51  ? 704  THR A N   1 
ATOM   3202 C  CA  . THR A 1 441 ? -3.490  -51.149 -31.000 1.00 24.10  ? 704  THR A CA  1 
ATOM   3203 C  C   . THR A 1 441 ? -2.824  -50.923 -29.642 1.00 24.33  ? 704  THR A C   1 
ATOM   3204 O  O   . THR A 1 441 ? -3.313  -51.508 -28.636 1.00 27.24  ? 704  THR A O   1 
ATOM   3205 C  CB  . THR A 1 441 ? -3.423  -52.626 -31.421 1.00 24.93  ? 704  THR A CB  1 
ATOM   3206 O  OG1 . THR A 1 441 ? -2.052  -53.027 -31.485 1.00 25.99  ? 704  THR A OG1 1 
ATOM   3207 C  CG2 . THR A 1 441 ? -4.152  -52.897 -32.726 1.00 24.15  ? 704  THR A CG2 1 
ATOM   3208 N  N   . GLN A 1 442 ? -1.767  -50.110 -29.564 1.00 23.05  ? 705  GLN A N   1 
ATOM   3209 C  CA  . GLN A 1 442 ? -1.063  -49.808 -28.302 1.00 25.31  ? 705  GLN A CA  1 
ATOM   3210 C  C   . GLN A 1 442 ? -1.432  -48.430 -27.762 1.00 22.04  ? 705  GLN A C   1 
ATOM   3211 O  O   . GLN A 1 442 ? -1.148  -48.192 -26.599 1.00 22.44  ? 705  GLN A O   1 
ATOM   3212 C  CB  . GLN A 1 442 ? 0.450   -49.913 -28.504 1.00 28.02  ? 705  GLN A CB  1 
ATOM   3213 C  CG  . GLN A 1 442 ? 0.827   -51.209 -29.226 1.00 32.97  ? 705  GLN A CG  1 
ATOM   3214 C  CD  . GLN A 1 442 ? 0.433   -52.406 -28.412 1.00 35.06  ? 705  GLN A CD  1 
ATOM   3215 O  OE1 . GLN A 1 442 ? 0.918   -52.560 -27.311 1.00 33.64  ? 705  GLN A OE1 1 
ATOM   3216 N  NE2 . GLN A 1 442 ? -0.434  -53.279 -28.943 1.00 40.04  ? 705  GLN A NE2 1 
ATOM   3217 N  N   . VAL A 1 443 ? -2.025  -47.579 -28.577 1.00 20.99  ? 706  VAL A N   1 
ATOM   3218 C  CA  . VAL A 1 443 ? -2.310  -46.149 -28.235 1.00 23.65  ? 706  VAL A CA  1 
ATOM   3219 C  C   . VAL A 1 443 ? -3.371  -46.093 -27.141 1.00 21.18  ? 706  VAL A C   1 
ATOM   3220 O  O   . VAL A 1 443 ? -4.428  -46.679 -27.285 1.00 22.65  ? 706  VAL A O   1 
ATOM   3221 C  CB  . VAL A 1 443 ? -2.784  -45.373 -29.477 1.00 27.99  ? 706  VAL A CB  1 
ATOM   3222 C  CG1 . VAL A 1 443 ? -3.270  -43.972 -29.163 1.00 32.30  ? 706  VAL A CG1 1 
ATOM   3223 C  CG2 . VAL A 1 443 ? -1.675  -45.305 -30.504 1.00 32.33  ? 706  VAL A CG2 1 
ATOM   3224 N  N   . PRO A 1 444 ? -3.162  -45.342 -26.043 1.00 21.55  ? 707  PRO A N   1 
ATOM   3225 C  CA  . PRO A 1 444 ? -4.237  -45.096 -25.090 1.00 19.97  ? 707  PRO A CA  1 
ATOM   3226 C  C   . PRO A 1 444 ? -5.202  -43.994 -25.550 1.00 21.77  ? 707  PRO A C   1 
ATOM   3227 O  O   . PRO A 1 444 ? -4.759  -42.998 -26.096 1.00 20.18  ? 707  PRO A O   1 
ATOM   3228 C  CB  . PRO A 1 444 ? -3.471  -44.647 -23.851 1.00 22.65  ? 707  PRO A CB  1 
ATOM   3229 C  CG  . PRO A 1 444 ? -2.228  -43.942 -24.398 1.00 22.71  ? 707  PRO A CG  1 
ATOM   3230 C  CD  . PRO A 1 444 ? -1.926  -44.619 -25.705 1.00 21.21  ? 707  PRO A CD  1 
ATOM   3231 N  N   . PHE A 1 445 ? -6.503  -44.167 -25.322 1.00 18.84  ? 708  PHE A N   1 
ATOM   3232 C  CA  . PHE A 1 445 ? -7.489  -43.104 -25.637 1.00 19.39  ? 708  PHE A CA  1 
ATOM   3233 C  C   . PHE A 1 445 ? -8.753  -43.357 -24.833 1.00 20.67  ? 708  PHE A C   1 
ATOM   3234 O  O   . PHE A 1 445 ? -9.216  -44.504 -24.840 1.00 18.46  ? 708  PHE A O   1 
ATOM   3235 C  CB  . PHE A 1 445 ? -7.820  -43.127 -27.128 1.00 19.09  ? 708  PHE A CB  1 
ATOM   3236 C  CG  . PHE A 1 445 ? -8.705  -41.995 -27.627 1.00 20.41  ? 708  PHE A CG  1 
ATOM   3237 C  CD1 . PHE A 1 445 ? -8.414  -40.680 -27.308 1.00 20.72  ? 708  PHE A CD1 1 
ATOM   3238 C  CD2 . PHE A 1 445 ? -9.833  -42.252 -28.396 1.00 22.36  ? 708  PHE A CD2 1 
ATOM   3239 C  CE1 . PHE A 1 445 ? -9.165  -39.624 -27.807 1.00 22.88  ? 708  PHE A CE1 1 
ATOM   3240 C  CE2 . PHE A 1 445 ? -10.600 -41.197 -28.888 1.00 22.94  ? 708  PHE A CE2 1 
ATOM   3241 C  CZ  . PHE A 1 445 ? -10.283 -39.887 -28.557 1.00 23.59  ? 708  PHE A CZ  1 
ATOM   3242 N  N   . CYS A 1 446 ? -9.264  -42.336 -24.140 1.00 20.30  ? 709  CYS A N   1 
ATOM   3243 C  CA  . CYS A 1 446 ? -10.528 -42.451 -23.338 1.00 22.13  ? 709  CYS A CA  1 
ATOM   3244 C  C   . CYS A 1 446 ? -10.429 -43.651 -22.373 1.00 20.63  ? 709  CYS A C   1 
ATOM   3245 O  O   . CYS A 1 446 ? -11.422 -44.411 -22.285 1.00 22.52  ? 709  CYS A O   1 
ATOM   3246 C  CB  . CYS A 1 446 ? -11.723 -42.564 -24.272 1.00 23.34  ? 709  CYS A CB  1 
ATOM   3247 S  SG  . CYS A 1 446 ? -11.946 -41.035 -25.238 1.00 26.58  ? 709  CYS A SG  1 
ATOM   3248 N  N   . SER A 1 447 ? -9.280  -43.807 -21.715 1.00 21.36  ? 710  SER A N   1 
ATOM   3249 C  CA  . SER A 1 447 ? -8.998  -44.825 -20.668 1.00 24.75  ? 710  SER A CA  1 
ATOM   3250 C  C   . SER A 1 447 ? -8.962  -46.259 -21.237 1.00 23.30  ? 710  SER A C   1 
ATOM   3251 O  O   . SER A 1 447 ? -8.882  -47.187 -20.439 1.00 24.44  ? 710  SER A O   1 
ATOM   3252 C  CB  . SER A 1 447 ? -10.020 -44.765 -19.526 1.00 26.96  ? 710  SER A CB  1 
ATOM   3253 O  OG  . SER A 1 447 ? -10.167 -43.443 -19.025 1.00 31.04  ? 710  SER A OG  1 
ATOM   3254 N  N   . HIS A 1 448 ? -8.871  -46.445 -22.545 1.00 19.78  ? 711  HIS A N   1 
ATOM   3255 C  CA  . HIS A 1 448 ? -8.882  -47.770 -23.209 1.00 17.44  ? 711  HIS A CA  1 
ATOM   3256 C  C   . HIS A 1 448 ? -7.674  -47.910 -24.139 1.00 18.65  ? 711  HIS A C   1 
ATOM   3257 O  O   . HIS A 1 448 ? -6.982  -46.918 -24.446 1.00 19.85  ? 711  HIS A O   1 
ATOM   3258 C  CB  . HIS A 1 448 ? -10.194 -48.009 -23.986 1.00 17.94  ? 711  HIS A CB  1 
ATOM   3259 C  CG  . HIS A 1 448 ? -11.382 -48.192 -23.107 1.00 19.45  ? 711  HIS A CG  1 
ATOM   3260 N  ND1 . HIS A 1 448 ? -11.987 -47.128 -22.428 1.00 18.96  ? 711  HIS A ND1 1 
ATOM   3261 C  CD2 . HIS A 1 448 ? -12.080 -49.312 -22.794 1.00 18.34  ? 711  HIS A CD2 1 
ATOM   3262 C  CE1 . HIS A 1 448 ? -12.985 -47.621 -21.677 1.00 21.21  ? 711  HIS A CE1 1 
ATOM   3263 N  NE2 . HIS A 1 448 ? -13.084 -48.961 -21.912 1.00 18.63  ? 711  HIS A NE2 1 
ATOM   3264 N  N   . HIS A 1 449 ? -7.446  -49.142 -24.544 1.00 16.83  ? 712  HIS A N   1 
ATOM   3265 C  CA  . HIS A 1 449 ? -6.729  -49.492 -25.781 1.00 17.71  ? 712  HIS A CA  1 
ATOM   3266 C  C   . HIS A 1 449 ? -7.658  -50.369 -26.583 1.00 17.90  ? 712  HIS A C   1 
ATOM   3267 O  O   . HIS A 1 449 ? -8.749  -50.707 -26.089 1.00 18.11  ? 712  HIS A O   1 
ATOM   3268 C  CB  . HIS A 1 449 ? -5.412  -50.228 -25.502 1.00 18.25  ? 712  HIS A CB  1 
ATOM   3269 C  CG  . HIS A 1 449 ? -5.587  -51.429 -24.653 1.00 17.48  ? 712  HIS A CG  1 
ATOM   3270 N  ND1 . HIS A 1 449 ? -5.756  -51.320 -23.292 1.00 17.79  ? 712  HIS A ND1 1 
ATOM   3271 C  CD2 . HIS A 1 449 ? -5.680  -52.729 -24.967 1.00 17.83  ? 712  HIS A CD2 1 
ATOM   3272 C  CE1 . HIS A 1 449 ? -5.951  -52.534 -22.802 1.00 17.74  ? 712  HIS A CE1 1 
ATOM   3273 N  NE2 . HIS A 1 449 ? -5.910  -53.421 -23.791 1.00 18.69  ? 712  HIS A NE2 1 
ATOM   3274 N  N   . PHE A 1 450 ? -7.242  -50.737 -27.783 1.00 18.77  ? 713  PHE A N   1 
ATOM   3275 C  CA  . PHE A 1 450 ? -8.143  -51.391 -28.750 1.00 19.25  ? 713  PHE A CA  1 
ATOM   3276 C  C   . PHE A 1 450 ? -7.446  -52.566 -29.420 1.00 19.97  ? 713  PHE A C   1 
ATOM   3277 O  O   . PHE A 1 450 ? -6.265  -52.485 -29.790 1.00 22.15  ? 713  PHE A O   1 
ATOM   3278 C  CB  . PHE A 1 450 ? -8.686  -50.345 -29.738 1.00 20.81  ? 713  PHE A CB  1 
ATOM   3279 C  CG  . PHE A 1 450 ? -9.420  -49.213 -29.055 1.00 19.40  ? 713  PHE A CG  1 
ATOM   3280 C  CD1 . PHE A 1 450 ? -8.714  -48.155 -28.523 1.00 22.66  ? 713  PHE A CD1 1 
ATOM   3281 C  CD2 . PHE A 1 450 ? -10.782 -49.264 -28.868 1.00 22.85  ? 713  PHE A CD2 1 
ATOM   3282 C  CE1 . PHE A 1 450 ? -9.378  -47.160 -27.821 1.00 22.86  ? 713  PHE A CE1 1 
ATOM   3283 C  CE2 . PHE A 1 450 ? -11.442 -48.267 -28.156 1.00 23.47  ? 713  PHE A CE2 1 
ATOM   3284 C  CZ  . PHE A 1 450 ? -10.726 -47.198 -27.678 1.00 22.27  ? 713  PHE A CZ  1 
ATOM   3285 N  N   . HIS A 1 451 ? -8.185  -53.669 -29.572 1.00 19.78  ? 714  HIS A N   1 
ATOM   3286 C  CA  . HIS A 1 451 ? -7.688  -54.931 -30.164 1.00 19.04  ? 714  HIS A CA  1 
ATOM   3287 C  C   . HIS A 1 451 ? -8.353  -55.174 -31.507 1.00 20.95  ? 714  HIS A C   1 
ATOM   3288 O  O   . HIS A 1 451 ? -9.564  -54.891 -31.637 1.00 21.01  ? 714  HIS A O   1 
ATOM   3289 C  CB  . HIS A 1 451 ? -7.946  -56.116 -29.212 1.00 19.74  ? 714  HIS A CB  1 
ATOM   3290 C  CG  . HIS A 1 451 ? -7.196  -56.126 -27.909 1.00 18.44  ? 714  HIS A CG  1 
ATOM   3291 N  ND1 . HIS A 1 451 ? -6.031  -56.834 -27.748 1.00 19.66  ? 714  HIS A ND1 1 
ATOM   3292 C  CD2 . HIS A 1 451 ? -7.443  -55.554 -26.706 1.00 18.47  ? 714  HIS A CD2 1 
ATOM   3293 C  CE1 . HIS A 1 451 ? -5.626  -56.730 -26.482 1.00 20.72  ? 714  HIS A CE1 1 
ATOM   3294 N  NE2 . HIS A 1 451 ? -6.460  -55.928 -25.800 1.00 16.43  ? 714  HIS A NE2 1 
ATOM   3295 N  N   . GLU A 1 452 ? -7.628  -55.766 -32.454 1.00 22.93  ? 715  GLU A N   1 
ATOM   3296 C  CA  . GLU A 1 452 ? -8.194  -56.260 -33.736 1.00 23.97  ? 715  GLU A CA  1 
ATOM   3297 C  C   . GLU A 1 452 ? -8.519  -57.746 -33.546 1.00 25.69  ? 715  GLU A C   1 
ATOM   3298 O  O   . GLU A 1 452 ? -7.664  -58.507 -33.144 1.00 29.09  ? 715  GLU A O   1 
ATOM   3299 C  CB  . GLU A 1 452 ? -7.203  -55.986 -34.879 1.00 29.30  ? 715  GLU A CB  1 
ATOM   3300 C  CG  . GLU A 1 452 ? -7.923  -55.648 -36.166 1.00 36.30  ? 715  GLU A CG  1 
ATOM   3301 C  CD  . GLU A 1 452 ? -7.027  -55.192 -37.319 1.00 41.54  ? 715  GLU A CD  1 
ATOM   3302 O  OE1 . GLU A 1 452 ? -7.513  -54.443 -38.213 1.00 38.49  ? 715  GLU A OE1 1 
ATOM   3303 O  OE2 . GLU A 1 452 ? -5.865  -55.630 -37.343 1.00 47.86  ? 715  GLU A OE2 1 
ATOM   3304 N  N   . LEU A 1 453 ? -9.765  -58.143 -33.664 1.00 23.66  ? 716  LEU A N   1 
ATOM   3305 C  CA  . LEU A 1 453 ? -10.190 -59.511 -33.283 1.00 27.15  ? 716  LEU A CA  1 
ATOM   3306 C  C   . LEU A 1 453 ? -10.877 -60.154 -34.481 1.00 30.45  ? 716  LEU A C   1 
ATOM   3307 O  O   . LEU A 1 453 ? -11.792 -59.527 -35.050 1.00 28.92  ? 716  LEU A O   1 
ATOM   3308 C  CB  . LEU A 1 453 ? -11.116 -59.309 -32.082 1.00 29.10  ? 716  LEU A CB  1 
ATOM   3309 C  CG  . LEU A 1 453 ? -11.811 -60.527 -31.523 1.00 34.12  ? 716  LEU A CG  1 
ATOM   3310 C  CD1 . LEU A 1 453 ? -10.821 -61.600 -31.112 1.00 38.00  ? 716  LEU A CD1 1 
ATOM   3311 C  CD2 . LEU A 1 453 ? -12.653 -60.094 -30.339 1.00 33.93  ? 716  LEU A CD2 1 
ATOM   3312 N  N   . ILE A 1 454 ? -10.392 -61.305 -34.930 1.00 29.12  ? 717  ILE A N   1 
ATOM   3313 C  CA  . ILE A 1 454 ? -10.935 -61.871 -36.194 1.00 30.56  ? 717  ILE A CA  1 
ATOM   3314 C  C   . ILE A 1 454 ? -11.921 -62.983 -35.837 1.00 28.00  ? 717  ILE A C   1 
ATOM   3315 O  O   . ILE A 1 454 ? -11.616 -63.826 -34.971 1.00 30.13  ? 717  ILE A O   1 
ATOM   3316 C  CB  . ILE A 1 454 ? -9.801  -62.276 -37.152 1.00 38.30  ? 717  ILE A CB  1 
ATOM   3317 C  CG1 . ILE A 1 454 ? -9.009  -61.035 -37.599 1.00 37.45  ? 717  ILE A CG1 1 
ATOM   3318 C  CG2 . ILE A 1 454 ? -10.340 -63.027 -38.375 1.00 42.27  ? 717  ILE A CG2 1 
ATOM   3319 C  CD1 . ILE A 1 454 ? -7.717  -61.382 -38.253 1.00 42.83  ? 717  ILE A CD1 1 
ATOM   3320 N  N   . MET A 1 455 ? -13.132 -62.853 -36.340 1.00 27.13  ? 718  MET A N   1 
ATOM   3321 C  CA  . MET A 1 455 ? -14.197 -63.848 -36.089 1.00 30.44  ? 718  MET A CA  1 
ATOM   3322 C  C   . MET A 1 455 ? -13.874 -65.113 -36.896 1.00 35.70  ? 718  MET A C   1 
ATOM   3323 O  O   . MET A 1 455 ? -13.201 -65.023 -37.964 1.00 31.09  ? 718  MET A O   1 
ATOM   3324 C  CB  . MET A 1 455 ? -15.543 -63.289 -36.540 1.00 29.80  ? 718  MET A CB  1 
ATOM   3325 C  CG  . MET A 1 455 ? -16.000 -62.103 -35.716 1.00 30.34  ? 718  MET A CG  1 
ATOM   3326 S  SD  . MET A 1 455 ? -17.488 -61.322 -36.307 1.00 32.51  ? 718  MET A SD  1 
ATOM   3327 C  CE  . MET A 1 455 ? -18.688 -62.556 -35.812 1.00 34.49  ? 718  MET A CE  1 
ATOM   3328 N  N   A LYS A 1 456 ? -14.354 -66.264 -36.424 0.25 35.56  ? 719  LYS A N   1 
ATOM   3329 N  N   B LYS A 1 456 ? -14.358 -66.263 -36.418 0.25 35.56  ? 719  LYS A N   1 
ATOM   3330 C  CA  A LYS A 1 456 ? -14.149 -67.574 -37.097 0.25 38.30  ? 719  LYS A CA  1 
ATOM   3331 C  CA  B LYS A 1 456 ? -14.172 -67.579 -37.088 0.25 38.33  ? 719  LYS A CA  1 
ATOM   3332 C  C   A LYS A 1 456 ? -14.581 -67.467 -38.566 0.25 37.18  ? 719  LYS A C   1 
ATOM   3333 C  C   B LYS A 1 456 ? -14.570 -67.453 -38.565 0.25 37.18  ? 719  LYS A C   1 
ATOM   3334 O  O   A LYS A 1 456 ? -13.966 -68.155 -39.402 0.25 39.37  ? 719  LYS A O   1 
ATOM   3335 O  O   B LYS A 1 456 ? -13.925 -68.115 -39.400 0.25 39.24  ? 719  LYS A O   1 
ATOM   3336 C  CB  A LYS A 1 456 ? -14.879 -68.676 -36.325 0.25 39.32  ? 719  LYS A CB  1 
ATOM   3337 C  CB  B LYS A 1 456 ? -14.967 -68.673 -36.369 0.25 39.42  ? 719  LYS A CB  1 
ATOM   3338 C  CG  A LYS A 1 456 ? -14.114 -69.200 -35.115 0.25 40.76  ? 719  LYS A CG  1 
ATOM   3339 C  CG  B LYS A 1 456 ? -14.575 -70.094 -36.755 0.25 41.21  ? 719  LYS A CG  1 
ATOM   3340 C  CD  A LYS A 1 456 ? -14.960 -70.002 -34.150 0.25 42.68  ? 719  LYS A CD  1 
ATOM   3341 C  CD  B LYS A 1 456 ? -15.110 -71.171 -35.834 0.25 41.71  ? 719  LYS A CD  1 
ATOM   3342 C  CE  A LYS A 1 456 ? -15.865 -69.143 -33.295 0.25 42.46  ? 719  LYS A CE  1 
ATOM   3343 C  CE  B LYS A 1 456 ? -15.256 -72.506 -36.535 0.25 43.47  ? 719  LYS A CE  1 
ATOM   3344 N  NZ  A LYS A 1 456 ? -16.821 -69.971 -32.526 0.25 43.30  ? 719  LYS A NZ  1 
ATOM   3345 N  NZ  B LYS A 1 456 ? -14.945 -73.641 -35.634 0.25 43.66  ? 719  LYS A NZ  1 
ATOM   3346 N  N   . ASP A 1 457 ? -15.552 -66.601 -38.876 1.00 36.39  ? 720  ASP A N   1 
ATOM   3347 C  CA  . ASP A 1 457 ? -16.039 -66.384 -40.269 1.00 36.78  ? 720  ASP A CA  1 
ATOM   3348 C  C   . ASP A 1 457 ? -15.222 -65.338 -41.052 1.00 48.06  ? 720  ASP A C   1 
ATOM   3349 O  O   . ASP A 1 457 ? -15.670 -64.959 -42.166 1.00 42.05  ? 720  ASP A O   1 
ATOM   3350 C  CB  . ASP A 1 457 ? -17.536 -66.043 -40.263 1.00 39.89  ? 720  ASP A CB  1 
ATOM   3351 C  CG  . ASP A 1 457 ? -17.907 -64.676 -39.704 1.00 39.83  ? 720  ASP A CG  1 
ATOM   3352 O  OD1 . ASP A 1 457 ? -17.034 -63.772 -39.685 1.00 34.65  ? 720  ASP A OD1 1 
ATOM   3353 O  OD2 . ASP A 1 457 ? -19.071 -64.516 -39.328 1.00 39.03  ? 720  ASP A OD2 1 
ATOM   3354 N  N   . GLY A 1 458 ? -14.093 -64.842 -40.517 1.00 44.16  ? 721  GLY A N   1 
ATOM   3355 C  CA  . GLY A 1 458 ? -13.202 -63.918 -41.247 1.00 38.39  ? 721  GLY A CA  1 
ATOM   3356 C  C   . GLY A 1 458 ? -13.501 -62.444 -41.030 1.00 37.80  ? 721  GLY A C   1 
ATOM   3357 O  O   . GLY A 1 458 ? -12.670 -61.626 -41.432 1.00 41.50  ? 721  GLY A O   1 
ATOM   3358 N  N   . ARG A 1 459 ? -14.632 -62.067 -40.438 1.00 32.56  ? 722  ARG A N   1 
ATOM   3359 C  CA  . ARG A 1 459 ? -14.991 -60.640 -40.338 1.00 30.32  ? 722  ARG A CA  1 
ATOM   3360 C  C   . ARG A 1 459 ? -14.145 -60.051 -39.183 1.00 31.39  ? 722  ARG A C   1 
ATOM   3361 O  O   . ARG A 1 459 ? -13.727 -60.811 -38.281 1.00 31.13  ? 722  ARG A O   1 
ATOM   3362 C  CB  . ARG A 1 459 ? -16.495 -60.447 -40.184 1.00 34.36  ? 722  ARG A CB  1 
ATOM   3363 C  CG  . ARG A 1 459 ? -17.319 -60.839 -41.412 1.00 33.10  ? 722  ARG A CG  1 
ATOM   3364 C  CD  . ARG A 1 459 ? -18.791 -60.561 -41.227 1.00 36.11  ? 722  ARG A CD  1 
ATOM   3365 N  NE  . ARG A 1 459 ? -19.388 -61.469 -40.271 1.00 33.58  ? 722  ARG A NE  1 
ATOM   3366 C  CZ  . ARG A 1 459 ? -20.657 -61.467 -39.971 1.00 30.41  ? 722  ARG A CZ  1 
ATOM   3367 N  NH1 . ARG A 1 459 ? -21.455 -60.554 -40.497 1.00 32.07  ? 722  ARG A NH1 1 
ATOM   3368 N  NH2 . ARG A 1 459 ? -21.132 -62.343 -39.103 1.00 34.93  ? 722  ARG A NH2 1 
ATOM   3369 N  N   . VAL A 1 460 ? -13.889 -58.757 -39.244 1.00 30.75  ? 723  VAL A N   1 
ATOM   3370 C  CA  . VAL A 1 460 ? -12.948 -58.063 -38.317 1.00 31.16  ? 723  VAL A CA  1 
ATOM   3371 C  C   . VAL A 1 460 ? -13.719 -57.197 -37.340 1.00 30.40  ? 723  VAL A C   1 
ATOM   3372 O  O   . VAL A 1 460 ? -14.458 -56.269 -37.750 1.00 37.09  ? 723  VAL A O   1 
ATOM   3373 C  CB  . VAL A 1 460 ? -11.871 -57.265 -39.060 1.00 33.70  ? 723  VAL A CB  1 
ATOM   3374 C  CG1 . VAL A 1 460 ? -10.950 -56.576 -38.051 1.00 35.34  ? 723  VAL A CG1 1 
ATOM   3375 C  CG2 . VAL A 1 460 ? -11.076 -58.188 -39.965 1.00 36.01  ? 723  VAL A CG2 1 
ATOM   3376 N  N   . LEU A 1 461 ? -13.482 -57.444 -36.045 1.00 26.30  ? 724  LEU A N   1 
ATOM   3377 C  CA  . LEU A 1 461 ? -14.013 -56.563 -35.002 1.00 22.06  ? 724  LEU A CA  1 
ATOM   3378 C  C   . LEU A 1 461 ? -12.827 -55.766 -34.426 1.00 22.44  ? 724  LEU A C   1 
ATOM   3379 O  O   . LEU A 1 461 ? -11.724 -56.319 -34.234 1.00 26.05  ? 724  LEU A O   1 
ATOM   3380 C  CB  . LEU A 1 461 ? -14.651 -57.396 -33.898 1.00 24.53  ? 724  LEU A CB  1 
ATOM   3381 C  CG  . LEU A 1 461 ? -15.806 -58.297 -34.311 1.00 24.92  ? 724  LEU A CG  1 
ATOM   3382 C  CD1 . LEU A 1 461 ? -16.076 -59.278 -33.196 1.00 27.06  ? 724  LEU A CD1 1 
ATOM   3383 C  CD2 . LEU A 1 461 ? -17.038 -57.508 -34.649 1.00 26.07  ? 724  LEU A CD2 1 
ATOM   3384 N  N   . VAL A 1 462 ? -13.039 -54.480 -34.188 0.50 21.56  ? 725  VAL A N   1 
ATOM   3385 C  CA  . VAL A 1 462 ? -12.083 -53.649 -33.404 0.50 20.69  ? 725  VAL A CA  1 
ATOM   3386 C  C   . VAL A 1 462 ? -12.771 -53.346 -32.074 0.50 19.48  ? 725  VAL A C   1 
ATOM   3387 O  O   . VAL A 1 462 ? -13.806 -52.666 -32.082 0.50 19.52  ? 725  VAL A O   1 
ATOM   3388 C  CB  . VAL A 1 462 ? -11.628 -52.397 -34.170 0.50 21.29  ? 725  VAL A CB  1 
ATOM   3389 C  CG1 . VAL A 1 462 ? -10.666 -51.566 -33.333 0.50 21.46  ? 725  VAL A CG1 1 
ATOM   3390 C  CG2 . VAL A 1 462 ? -11.001 -52.766 -35.507 0.50 21.32  ? 725  VAL A CG2 1 
ATOM   3391 N  N   . VAL A 1 463 ? -12.229 -53.893 -30.981 1.00 19.19  ? 726  VAL A N   1 
ATOM   3392 C  CA  . VAL A 1 463 ? -12.905 -53.900 -29.667 1.00 19.22  ? 726  VAL A CA  1 
ATOM   3393 C  C   . VAL A 1 463 ? -12.162 -53.074 -28.631 1.00 18.94  ? 726  VAL A C   1 
ATOM   3394 O  O   . VAL A 1 463 ? -10.932 -53.010 -28.637 1.00 19.24  ? 726  VAL A O   1 
ATOM   3395 C  CB  . VAL A 1 463 ? -13.118 -55.345 -29.205 1.00 19.65  ? 726  VAL A CB  1 
ATOM   3396 C  CG1 . VAL A 1 463 ? -13.909 -56.131 -30.237 1.00 21.00  ? 726  VAL A CG1 1 
ATOM   3397 C  CG2 . VAL A 1 463 ? -11.800 -56.034 -28.933 1.00 19.10  ? 726  VAL A CG2 1 
ATOM   3398 N  N   . PRO A 1 464 ? -12.931 -52.446 -27.721 1.00 18.58  ? 727  PRO A N   1 
ATOM   3399 C  CA  . PRO A 1 464 ? -12.365 -51.679 -26.605 1.00 17.18  ? 727  PRO A CA  1 
ATOM   3400 C  C   . PRO A 1 464 ? -11.882 -52.601 -25.482 1.00 18.09  ? 727  PRO A C   1 
ATOM   3401 O  O   . PRO A 1 464 ? -12.492 -53.640 -25.224 1.00 18.23  ? 727  PRO A O   1 
ATOM   3402 C  CB  . PRO A 1 464 ? -13.544 -50.820 -26.178 1.00 18.48  ? 727  PRO A CB  1 
ATOM   3403 C  CG  . PRO A 1 464 ? -14.748 -51.702 -26.443 1.00 18.41  ? 727  PRO A CG  1 
ATOM   3404 C  CD  . PRO A 1 464 ? -14.410 -52.387 -27.751 1.00 18.85  ? 727  PRO A CD  1 
ATOM   3405 N  N   . CYS A 1 465 ? -10.876 -52.171 -24.730 1.00 16.85  ? 728  CYS A N   1 
ATOM   3406 C  CA  . CYS A 1 465 ? -10.286 -53.029 -23.666 1.00 17.00  ? 728  CYS A CA  1 
ATOM   3407 C  C   . CYS A 1 465 ? -9.622  -52.141 -22.622 1.00 19.14  ? 728  CYS A C   1 
ATOM   3408 O  O   . CYS A 1 465 ? -9.141  -51.065 -22.968 1.00 17.50  ? 728  CYS A O   1 
ATOM   3409 C  CB  . CYS A 1 465 ? -9.294  -54.032 -24.261 1.00 17.82  ? 728  CYS A CB  1 
ATOM   3410 S  SG  . CYS A 1 465 ? -8.747  -55.354 -23.120 1.00 18.12  ? 728  CYS A SG  1 
ATOM   3411 N  N   . ARG A 1 466 ? -9.563  -52.614 -21.390 1.00 19.15  ? 729  ARG A N   1 
ATOM   3412 C  CA  . ARG A 1 466 ? -8.692  -52.012 -20.370 1.00 20.64  ? 729  ARG A CA  1 
ATOM   3413 C  C   . ARG A 1 466 ? -8.421  -53.072 -19.328 1.00 18.48  ? 729  ARG A C   1 
ATOM   3414 O  O   . ARG A 1 466 ? -8.983  -54.185 -19.411 1.00 17.99  ? 729  ARG A O   1 
ATOM   3415 C  CB  . ARG A 1 466 ? -9.299  -50.760 -19.738 1.00 25.38  ? 729  ARG A CB  1 
ATOM   3416 C  CG  . ARG A 1 466 ? -10.581 -50.941 -18.984 1.00 28.73  ? 729  ARG A CG  1 
ATOM   3417 C  CD  . ARG A 1 466 ? -11.323 -49.617 -18.732 1.00 27.18  ? 729  ARG A CD  1 
ATOM   3418 N  NE  . ARG A 1 466 ? -10.720 -48.800 -17.708 1.00 25.52  ? 729  ARG A NE  1 
ATOM   3419 C  CZ  . ARG A 1 466 ? -11.263 -47.655 -17.250 1.00 26.34  ? 729  ARG A CZ  1 
ATOM   3420 N  NH1 . ARG A 1 466 ? -12.446 -47.228 -17.669 1.00 28.00  ? 729  ARG A NH1 1 
ATOM   3421 N  NH2 . ARG A 1 466 ? -10.623 -46.972 -16.353 1.00 28.45  ? 729  ARG A NH2 1 
ATOM   3422 N  N   . ASN A 1 467 ? -7.457  -52.791 -18.471 1.00 18.96  ? 730  ASN A N   1 
ATOM   3423 C  CA  . ASN A 1 467 ? -7.057  -53.811 -17.468 1.00 19.46  ? 730  ASN A CA  1 
ATOM   3424 C  C   . ASN A 1 467 ? -8.335  -54.283 -16.749 1.00 17.79  ? 730  ASN A C   1 
ATOM   3425 O  O   . ASN A 1 467 ? -9.092  -53.432 -16.226 1.00 17.62  ? 730  ASN A O   1 
ATOM   3426 C  CB  . ASN A 1 467 ? -6.010  -53.234 -16.519 1.00 20.43  ? 730  ASN A CB  1 
ATOM   3427 C  CG  . ASN A 1 467 ? -5.667  -54.265 -15.471 1.00 24.35  ? 730  ASN A CG  1 
ATOM   3428 O  OD1 . ASN A 1 467 ? -6.346  -54.333 -14.460 1.00 24.06  ? 730  ASN A OD1 1 
ATOM   3429 N  ND2 . ASN A 1 467 ? -4.739  -55.180 -15.795 1.00 26.35  ? 730  ASN A ND2 1 
ATOM   3430 N  N   . GLN A 1 468 ? -8.519  -55.589 -16.599 1.00 17.69  ? 731  GLN A N   1 
ATOM   3431 C  CA  . GLN A 1 468 ? -9.812  -56.138 -16.120 1.00 18.55  ? 731  GLN A CA  1 
ATOM   3432 C  C   . GLN A 1 468 ? -10.042 -55.809 -14.647 1.00 18.12  ? 731  GLN A C   1 
ATOM   3433 O  O   . GLN A 1 468 ? -11.217 -55.708 -14.217 1.00 17.60  ? 731  GLN A O   1 
ATOM   3434 C  CB  . GLN A 1 468 ? -9.848  -57.614 -16.429 1.00 20.00  ? 731  GLN A CB  1 
ATOM   3435 C  CG  . GLN A 1 468 ? -11.194 -58.239 -16.217 1.00 20.50  ? 731  GLN A CG  1 
ATOM   3436 C  CD  . GLN A 1 468 ? -11.171 -59.723 -16.453 1.00 20.35  ? 731  GLN A CD  1 
ATOM   3437 O  OE1 . GLN A 1 468 ? -11.575 -60.173 -17.511 1.00 20.73  ? 731  GLN A OE1 1 
ATOM   3438 N  NE2 . GLN A 1 468 ? -10.820 -60.489 -15.442 1.00 20.13  ? 731  GLN A NE2 1 
ATOM   3439 N  N   . ASP A 1 469 ? -8.979  -55.624 -13.861 1.00 19.00  ? 732  ASP A N   1 
ATOM   3440 C  CA  . ASP A 1 469 ? -9.205  -55.233 -12.441 1.00 20.87  ? 732  ASP A CA  1 
ATOM   3441 C  C   . ASP A 1 469 ? -9.962  -53.912 -12.363 1.00 20.06  ? 732  ASP A C   1 
ATOM   3442 O  O   . ASP A 1 469 ? -10.779 -53.703 -11.414 1.00 19.46  ? 732  ASP A O   1 
ATOM   3443 C  CB  . ASP A 1 469 ? -7.870  -55.108 -11.707 1.00 21.07  ? 732  ASP A CB  1 
ATOM   3444 C  CG  . ASP A 1 469 ? -7.131  -56.427 -11.499 1.00 23.76  ? 732  ASP A CG  1 
ATOM   3445 O  OD1 . ASP A 1 469 ? -7.720  -57.506 -11.633 1.00 21.74  ? 732  ASP A OD1 1 
ATOM   3446 O  OD2 . ASP A 1 469 ? -5.928  -56.351 -11.194 1.00 26.01  ? 732  ASP A OD2 1 
ATOM   3447 N  N   . GLU A 1 470 ? -9.680  -52.975 -13.270 1.00 18.94  ? 733  GLU A N   1 
ATOM   3448 C  CA  . GLU A 1 470 ? -10.347 -51.647 -13.287 1.00 19.31  ? 733  GLU A CA  1 
ATOM   3449 C  C   . GLU A 1 470 ? -11.841 -51.847 -13.576 1.00 17.55  ? 733  GLU A C   1 
ATOM   3450 O  O   . GLU A 1 470 ? -12.693 -51.158 -12.962 1.00 20.11  ? 733  GLU A O   1 
ATOM   3451 C  CB  . GLU A 1 470 ? -9.758  -50.759 -14.383 1.00 21.18  ? 733  GLU A CB  1 
ATOM   3452 C  CG  . GLU A 1 470 ? -8.280  -50.446 -14.232 1.00 27.22  ? 733  GLU A CG  1 
ATOM   3453 C  CD  . GLU A 1 470 ? -7.668  -49.664 -15.403 1.00 34.42  ? 733  GLU A CD  1 
ATOM   3454 O  OE1 . GLU A 1 470 ? -6.435  -49.584 -15.442 1.00 38.41  ? 733  GLU A OE1 1 
ATOM   3455 O  OE2 . GLU A 1 470 ? -8.401  -49.132 -16.272 1.00 33.46  ? 733  GLU A OE2 1 
ATOM   3456 N  N   . LEU A 1 471 ? -12.166 -52.740 -14.498 1.00 17.98  ? 734  LEU A N   1 
ATOM   3457 C  CA  . LEU A 1 471 ? -13.588 -52.945 -14.881 1.00 17.01  ? 734  LEU A CA  1 
ATOM   3458 C  C   . LEU A 1 471 ? -14.364 -53.588 -13.723 1.00 16.71  ? 734  LEU A C   1 
ATOM   3459 O  O   . LEU A 1 471 ? -15.450 -53.112 -13.391 1.00 18.77  ? 734  LEU A O   1 
ATOM   3460 C  CB  . LEU A 1 471 ? -13.635 -53.801 -16.150 1.00 17.00  ? 734  LEU A CB  1 
ATOM   3461 C  CG  . LEU A 1 471 ? -13.088 -53.110 -17.397 1.00 19.19  ? 734  LEU A CG  1 
ATOM   3462 C  CD1 . LEU A 1 471 ? -12.941 -54.087 -18.551 1.00 18.44  ? 734  LEU A CD1 1 
ATOM   3463 C  CD2 . LEU A 1 471 ? -13.974 -51.943 -17.795 1.00 21.76  ? 734  LEU A CD2 1 
ATOM   3464 N  N   . ILE A 1 472 ? -13.804 -54.645 -13.154 1.00 17.90  ? 735  ILE A N   1 
ATOM   3465 C  CA  . ILE A 1 472 ? -14.493 -55.363 -12.045 1.00 18.39  ? 735  ILE A CA  1 
ATOM   3466 C  C   . ILE A 1 472 ? -14.593 -54.444 -10.819 1.00 17.03  ? 735  ILE A C   1 
ATOM   3467 O  O   . ILE A 1 472 ? -15.651 -54.393 -10.206 1.00 17.99  ? 735  ILE A O   1 
ATOM   3468 C  CB  . ILE A 1 472 ? -13.765 -56.687 -11.755 1.00 18.05  ? 735  ILE A CB  1 
ATOM   3469 C  CG1 . ILE A 1 472 ? -13.900 -57.632 -12.950 1.00 20.02  ? 735  ILE A CG1 1 
ATOM   3470 C  CG2 . ILE A 1 472 ? -14.264 -57.315 -10.464 1.00 18.17  ? 735  ILE A CG2 1 
ATOM   3471 C  CD1 . ILE A 1 472 ? -13.207 -58.951 -12.784 1.00 24.84  ? 735  ILE A CD1 1 
ATOM   3472 N  N   . GLY A 1 473 ? -13.511 -53.739 -10.516 1.00 17.85  ? 736  GLY A N   1 
ATOM   3473 C  CA  . GLY A 1 473 ? -13.521 -52.842 -9.350  1.00 18.97  ? 736  GLY A CA  1 
ATOM   3474 C  C   . GLY A 1 473 ? -14.596 -51.765 -9.455  1.00 19.68  ? 736  GLY A C   1 
ATOM   3475 O  O   . GLY A 1 473 ? -15.214 -51.447 -8.442  1.00 18.71  ? 736  GLY A O   1 
ATOM   3476 N  N   . ARG A 1 474 ? -14.793 -51.221 -10.654 1.00 18.59  ? 737  ARG A N   1 
ATOM   3477 C  CA  . ARG A 1 474 ? -15.796 -50.141 -10.854 1.00 19.51  ? 737  ARG A CA  1 
ATOM   3478 C  C   . ARG A 1 474 ? -17.221 -50.696 -10.724 1.00 19.62  ? 737  ARG A C   1 
ATOM   3479 O  O   . ARG A 1 474 ? -18.056 -50.017 -10.142 1.00 20.54  ? 737  ARG A O   1 
ATOM   3480 C  CB  . ARG A 1 474 ? -15.609 -49.498 -12.235 1.00 23.23  ? 737  ARG A CB  1 
ATOM   3481 C  CG  . ARG A 1 474 ? -14.223 -48.922 -12.474 1.00 34.50  ? 737  ARG A CG  1 
ATOM   3482 C  CD  . ARG A 1 474 ? -13.960 -48.606 -13.934 1.00 42.17  ? 737  ARG A CD  1 
ATOM   3483 N  NE  . ARG A 1 474 ? -14.505 -47.304 -14.272 1.00 47.64  ? 737  ARG A NE  1 
ATOM   3484 C  CZ  . ARG A 1 474 ? -13.902 -46.160 -13.988 1.00 47.77  ? 737  ARG A CZ  1 
ATOM   3485 N  NH1 . ARG A 1 474 ? -14.466 -45.013 -14.323 1.00 52.36  ? 737  ARG A NH1 1 
ATOM   3486 N  NH2 . ARG A 1 474 ? -12.738 -46.170 -13.366 1.00 45.13  ? 737  ARG A NH2 1 
ATOM   3487 N  N   . ALA A 1 475 ? -17.469 -51.882 -11.272 1.00 19.15  ? 738  ALA A N   1 
ATOM   3488 C  CA  . ALA A 1 475 ? -18.815 -52.502 -11.221 1.00 17.70  ? 738  ALA A CA  1 
ATOM   3489 C  C   . ALA A 1 475 ? -19.199 -52.870 -9.781  1.00 20.55  ? 738  ALA A C   1 
ATOM   3490 O  O   . ALA A 1 475 ? -20.386 -53.018 -9.512  1.00 20.74  ? 738  ALA A O   1 
ATOM   3491 C  CB  . ALA A 1 475 ? -18.850 -53.712 -12.113 1.00 18.20  ? 738  ALA A CB  1 
ATOM   3492 N  N   . ARG A 1 476 ? -18.205 -53.016 -8.910  1.00 17.88  ? 739  ARG A N   1 
ATOM   3493 C  CA  . ARG A 1 476 ? -18.483 -53.407 -7.501  1.00 19.96  ? 739  ARG A CA  1 
ATOM   3494 C  C   . ARG A 1 476 ? -18.798 -52.159 -6.660  1.00 21.74  ? 739  ARG A C   1 
ATOM   3495 O  O   . ARG A 1 476 ? -19.029 -52.303 -5.465  1.00 20.55  ? 739  ARG A O   1 
ATOM   3496 C  CB  . ARG A 1 476 ? -17.318 -54.240 -6.957  1.00 19.39  ? 739  ARG A CB  1 
ATOM   3497 C  CG  . ARG A 1 476 ? -17.312 -55.677 -7.456  1.00 19.17  ? 739  ARG A CG  1 
ATOM   3498 C  CD  . ARG A 1 476 ? -15.977 -56.385 -7.322  1.00 21.69  ? 739  ARG A CD  1 
ATOM   3499 N  NE  . ARG A 1 476 ? -15.480 -56.540 -5.966  1.00 21.24  ? 739  ARG A NE  1 
ATOM   3500 C  CZ  . ARG A 1 476 ? -15.218 -57.701 -5.380  1.00 19.29  ? 739  ARG A CZ  1 
ATOM   3501 N  NH1 . ARG A 1 476 ? -15.419 -58.835 -6.026  1.00 19.49  ? 739  ARG A NH1 1 
ATOM   3502 N  NH2 . ARG A 1 476 ? -14.751 -57.722 -4.148  1.00 19.73  ? 739  ARG A NH2 1 
ATOM   3503 N  N   . ILE A 1 477 ? -18.844 -50.993 -7.303  1.00 21.64  ? 740  ILE A N   1 
ATOM   3504 C  CA  . ILE A 1 477 ? -19.037 -49.729 -6.541  1.00 27.85  ? 740  ILE A CA  1 
ATOM   3505 C  C   . ILE A 1 477 ? -20.319 -48.988 -6.910  1.00 31.10  ? 740  ILE A C   1 
ATOM   3506 O  O   . ILE A 1 477 ? -20.732 -49.061 -8.066  1.00 27.28  ? 740  ILE A O   1 
ATOM   3507 C  CB  . ILE A 1 477 ? -17.829 -48.787 -6.727  1.00 28.59  ? 740  ILE A CB  1 
ATOM   3508 C  CG1 . ILE A 1 477 ? -16.567 -49.330 -6.056  1.00 29.35  ? 740  ILE A CG1 1 
ATOM   3509 C  CG2 . ILE A 1 477 ? -18.154 -47.383 -6.244  1.00 36.60  ? 740  ILE A CG2 1 
ATOM   3510 C  CD1 . ILE A 1 477 ? -15.336 -48.511 -6.345  1.00 32.12  ? 740  ILE A CD1 1 
ATOM   3511 N  N   A SER A 1 478 ? -21.001 -48.430 -5.907  0.25 34.05  ? 741  SER A N   1 
ATOM   3512 N  N   B SER A 1 478 ? -21.003 -48.432 -5.907  0.25 34.29  ? 741  SER A N   1 
ATOM   3513 C  CA  A SER A 1 478 ? -22.227 -47.634 -6.169  0.25 37.22  ? 741  SER A CA  1 
ATOM   3514 C  CA  B SER A 1 478 ? -22.225 -47.630 -6.174  0.25 37.57  ? 741  SER A CA  1 
ATOM   3515 C  C   A SER A 1 478 ? -22.085 -46.308 -5.417  0.25 40.29  ? 741  SER A C   1 
ATOM   3516 C  C   B SER A 1 478 ? -22.097 -46.312 -5.407  0.25 41.25  ? 741  SER A C   1 
ATOM   3517 O  O   A SER A 1 478 ? -21.110 -46.179 -4.651  0.25 37.70  ? 741  SER A O   1 
ATOM   3518 O  O   B SER A 1 478 ? -21.120 -46.184 -4.645  0.25 41.06  ? 741  SER A O   1 
ATOM   3519 C  CB  A SER A 1 478 ? -23.457 -48.375 -5.733  0.25 37.61  ? 741  SER A CB  1 
ATOM   3520 C  CB  B SER A 1 478 ? -23.472 -48.375 -5.786  0.25 37.58  ? 741  SER A CB  1 
ATOM   3521 O  OG  A SER A 1 478 ? -24.599 -47.538 -5.804  0.25 37.76  ? 741  SER A OG  1 
ATOM   3522 O  OG  B SER A 1 478 ? -23.426 -48.765 -4.422  0.25 37.00  ? 741  SER A OG  1 
ATOM   3523 N  N   . GLN A 1 479 ? -22.828 -45.285 -5.846  0.50 44.69  ? 742  GLN A N   1 
ATOM   3524 C  CA  . GLN A 1 479 ? -22.748 -43.956 -5.187  0.50 47.84  ? 742  GLN A CA  1 
ATOM   3525 C  C   . GLN A 1 479 ? -24.125 -43.555 -4.651  0.50 46.74  ? 742  GLN A C   1 
ATOM   3526 O  O   . GLN A 1 479 ? -25.119 -43.898 -5.304  0.50 40.39  ? 742  GLN A O   1 
ATOM   3527 C  CB  . GLN A 1 479 ? -22.222 -42.918 -6.181  0.50 52.20  ? 742  GLN A CB  1 
ATOM   3528 C  CG  . GLN A 1 479 ? -20.988 -43.370 -6.947  0.50 56.01  ? 742  GLN A CG  1 
ATOM   3529 C  CD  . GLN A 1 479 ? -19.733 -43.322 -6.113  0.50 58.37  ? 742  GLN A CD  1 
ATOM   3530 O  OE1 . GLN A 1 479 ? -19.694 -42.709 -5.049  0.50 60.21  ? 742  GLN A OE1 1 
ATOM   3531 N  NE2 . GLN A 1 479 ? -18.686 -43.965 -6.601  0.50 58.61  ? 742  GLN A NE2 1 
ATOM   3532 N  N   . GLY A 1 480 ? -24.167 -42.871 -3.502  0.50 47.79  ? 743  GLY A N   1 
ATOM   3533 C  CA  . GLY A 1 480 ? -25.443 -42.362 -2.960  0.50 48.33  ? 743  GLY A CA  1 
ATOM   3534 C  C   . GLY A 1 480 ? -26.090 -43.330 -1.983  0.50 47.85  ? 743  GLY A C   1 
ATOM   3535 O  O   . GLY A 1 480 ? -25.667 -44.501 -1.926  0.50 46.78  ? 743  GLY A O   1 
ATOM   3536 N  N   . ALA A 1 481 ? -27.096 -42.844 -1.249  1.00 48.68  ? 744  ALA A N   1 
ATOM   3537 C  CA  . ALA A 1 481 ? -27.810 -43.587 -0.189  1.00 45.68  ? 744  ALA A CA  1 
ATOM   3538 C  C   . ALA A 1 481 ? -29.170 -44.089 -0.691  1.00 39.34  ? 744  ALA A C   1 
ATOM   3539 O  O   . ALA A 1 481 ? -29.618 -43.678 -1.781  1.00 37.06  ? 744  ALA A O   1 
ATOM   3540 C  CB  . ALA A 1 481 ? -28.003 -42.650 0.991   1.00 45.94  ? 744  ALA A CB  1 
ATOM   3541 N  N   . GLY A 1 482 ? -29.801 -44.936 0.118   1.00 34.42  ? 745  GLY A N   1 
ATOM   3542 C  CA  . GLY A 1 482 ? -31.202 -45.368 -0.029  1.00 35.26  ? 745  GLY A CA  1 
ATOM   3543 C  C   . GLY A 1 482 ? -31.364 -46.337 -1.172  1.00 34.04  ? 745  GLY A C   1 
ATOM   3544 O  O   . GLY A 1 482 ? -32.443 -46.337 -1.780  1.00 38.88  ? 745  GLY A O   1 
ATOM   3545 N  N   . TRP A 1 483 ? -30.318 -47.101 -1.535  1.00 28.13  ? 746  TRP A N   1 
ATOM   3546 C  CA  . TRP A 1 483 ? -30.487 -48.136 -2.588  1.00 28.46  ? 746  TRP A CA  1 
ATOM   3547 C  C   . TRP A 1 483 ? -31.266 -49.333 -2.035  1.00 26.03  ? 746  TRP A C   1 
ATOM   3548 O  O   . TRP A 1 483 ? -30.807 -50.023 -1.115  1.00 24.98  ? 746  TRP A O   1 
ATOM   3549 C  CB  . TRP A 1 483 ? -29.148 -48.598 -3.144  1.00 34.01  ? 746  TRP A CB  1 
ATOM   3550 C  CG  . TRP A 1 483 ? -28.406 -47.583 -3.953  1.00 37.00  ? 746  TRP A CG  1 
ATOM   3551 C  CD1 . TRP A 1 483 ? -27.643 -46.554 -3.465  1.00 44.60  ? 746  TRP A CD1 1 
ATOM   3552 C  CD2 . TRP A 1 483 ? -28.248 -47.563 -5.378  1.00 36.08  ? 746  TRP A CD2 1 
ATOM   3553 N  NE1 . TRP A 1 483 ? -27.072 -45.851 -4.496  1.00 44.71  ? 746  TRP A NE1 1 
ATOM   3554 C  CE2 . TRP A 1 483 ? -27.400 -46.466 -5.680  1.00 43.74  ? 746  TRP A CE2 1 
ATOM   3555 C  CE3 . TRP A 1 483 ? -28.704 -48.373 -6.423  1.00 32.78  ? 746  TRP A CE3 1 
ATOM   3556 C  CZ2 . TRP A 1 483 ? -27.040 -46.156 -6.990  1.00 40.50  ? 746  TRP A CZ2 1 
ATOM   3557 C  CZ3 . TRP A 1 483 ? -28.362 -48.052 -7.713  1.00 33.55  ? 746  TRP A CZ3 1 
ATOM   3558 C  CH2 . TRP A 1 483 ? -27.556 -46.951 -7.992  1.00 37.55  ? 746  TRP A CH2 1 
ATOM   3559 N  N   . SER A 1 484 ? -32.403 -49.658 -2.636  1.00 23.96  ? 747  SER A N   1 
ATOM   3560 C  CA  . SER A 1 484 ? -33.085 -50.936 -2.374  1.00 22.26  ? 747  SER A CA  1 
ATOM   3561 C  C   . SER A 1 484 ? -32.253 -52.090 -2.934  1.00 19.36  ? 747  SER A C   1 
ATOM   3562 O  O   . SER A 1 484 ? -31.353 -51.805 -3.746  1.00 21.94  ? 747  SER A O   1 
ATOM   3563 C  CB  . SER A 1 484 ? -34.494 -50.928 -2.963  1.00 23.27  ? 747  SER A CB  1 
ATOM   3564 O  OG  . SER A 1 484 ? -34.436 -50.960 -4.373  1.00 22.61  ? 747  SER A OG  1 
ATOM   3565 N  N   . LEU A 1 485 ? -32.578 -53.327 -2.566  1.00 20.34  ? 748  LEU A N   1 
ATOM   3566 C  CA  . LEU A 1 485 ? -31.965 -54.522 -3.202  1.00 20.60  ? 748  LEU A CA  1 
ATOM   3567 C  C   . LEU A 1 485 ? -32.299 -54.556 -4.706  1.00 21.49  ? 748  LEU A C   1 
ATOM   3568 O  O   . LEU A 1 485 ? -31.423 -54.828 -5.544  1.00 20.23  ? 748  LEU A O   1 
ATOM   3569 C  CB  . LEU A 1 485 ? -32.435 -55.796 -2.501  1.00 21.60  ? 748  LEU A CB  1 
ATOM   3570 C  CG  . LEU A 1 485 ? -31.808 -57.073 -3.039  1.00 24.71  ? 748  LEU A CG  1 
ATOM   3571 C  CD1 . LEU A 1 485 ? -30.282 -56.966 -3.118  1.00 25.05  ? 748  LEU A CD1 1 
ATOM   3572 C  CD2 . LEU A 1 485 ? -32.208 -58.273 -2.203  1.00 26.78  ? 748  LEU A CD2 1 
ATOM   3573 N  N   . ARG A 1 486 ? -33.545 -54.230 -5.079  1.00 21.86  ? 749  ARG A N   1 
ATOM   3574 C  CA  . ARG A 1 486 ? -33.921 -54.202 -6.512  1.00 21.67  ? 749  ARG A CA  1 
ATOM   3575 C  C   . ARG A 1 486 ? -33.085 -53.151 -7.247  1.00 20.11  ? 749  ARG A C   1 
ATOM   3576 O  O   . ARG A 1 486 ? -32.620 -53.436 -8.349  1.00 20.53  ? 749  ARG A O   1 
ATOM   3577 C  CB  . ARG A 1 486 ? -35.417 -53.911 -6.661  1.00 22.41  ? 749  ARG A CB  1 
ATOM   3578 C  CG  . ARG A 1 486 ? -35.851 -53.651 -8.100  1.00 25.21  ? 749  ARG A CG  1 
ATOM   3579 C  CD  . ARG A 1 486 ? -37.359 -53.763 -8.146  1.00 26.11  ? 749  ARG A CD  1 
ATOM   3580 N  NE  . ARG A 1 486 ? -37.879 -53.603 -9.505  1.00 25.92  ? 749  ARG A NE  1 
ATOM   3581 C  CZ  . ARG A 1 486 ? -39.022 -54.137 -9.883  1.00 24.63  ? 749  ARG A CZ  1 
ATOM   3582 N  NH1 . ARG A 1 486 ? -39.720 -54.844 -9.002  1.00 24.59  ? 749  ARG A NH1 1 
ATOM   3583 N  NH2 . ARG A 1 486 ? -39.442 -53.973 -11.125 1.00 25.14  ? 749  ARG A NH2 1 
ATOM   3584 N  N   . GLU A 1 487 ? -32.933 -51.950 -6.711  1.00 20.09  ? 750  GLU A N   1 
ATOM   3585 C  CA  . GLU A 1 487 ? -32.160 -50.903 -7.418  1.00 21.48  ? 750  GLU A CA  1 
ATOM   3586 C  C   . GLU A 1 487 ? -30.684 -51.334 -7.538  1.00 20.65  ? 750  GLU A C   1 
ATOM   3587 O  O   . GLU A 1 487 ? -30.046 -51.099 -8.607  1.00 19.42  ? 750  GLU A O   1 
ATOM   3588 C  CB  . GLU A 1 487 ? -32.217 -49.560 -6.712  1.00 26.79  ? 750  GLU A CB  1 
ATOM   3589 C  CG  . GLU A 1 487 ? -31.919 -48.419 -7.670  1.00 34.86  ? 750  GLU A CG  1 
ATOM   3590 C  CD  . GLU A 1 487 ? -31.825 -47.011 -7.104  1.00 42.76  ? 750  GLU A CD  1 
ATOM   3591 O  OE1 . GLU A 1 487 ? -32.023 -46.839 -5.861  1.00 43.50  ? 750  GLU A OE1 1 
ATOM   3592 O  OE2 . GLU A 1 487 ? -31.559 -46.084 -7.918  1.00 44.04  ? 750  GLU A OE2 1 
ATOM   3593 N  N   . THR A 1 488 ? -30.154 -51.968 -6.488  1.00 20.14  ? 751  THR A N   1 
ATOM   3594 C  CA  . THR A 1 488 ? -28.741 -52.459 -6.512  1.00 19.40  ? 751  THR A CA  1 
ATOM   3595 C  C   . THR A 1 488 ? -28.610 -53.538 -7.601  1.00 19.11  ? 751  THR A C   1 
ATOM   3596 O  O   . THR A 1 488 ? -27.624 -53.513 -8.417  1.00 19.42  ? 751  THR A O   1 
ATOM   3597 C  CB  . THR A 1 488 ? -28.367 -53.025 -5.145  1.00 20.31  ? 751  THR A CB  1 
ATOM   3598 O  OG1 . THR A 1 488 ? -28.600 -52.006 -4.164  1.00 21.58  ? 751  THR A OG1 1 
ATOM   3599 C  CG2 . THR A 1 488 ? -26.935 -53.512 -5.117  1.00 19.74  ? 751  THR A CG2 1 
ATOM   3600 N  N   . ALA A 1 489 ? -29.543 -54.490 -7.661  1.00 18.83  ? 752  ALA A N   1 
ATOM   3601 C  CA  . ALA A 1 489 ? -29.554 -55.542 -8.697  1.00 20.15  ? 752  ALA A CA  1 
ATOM   3602 C  C   . ALA A 1 489 ? -29.624 -54.927 -10.110 1.00 22.68  ? 752  ALA A C   1 
ATOM   3603 O  O   . ALA A 1 489 ? -28.944 -55.418 -11.032 1.00 20.19  ? 752  ALA A O   1 
ATOM   3604 C  CB  . ALA A 1 489 ? -30.716 -56.467 -8.441  1.00 19.28  ? 752  ALA A CB  1 
ATOM   3605 N  N   . CYS A 1 490 ? -30.464 -53.910 -10.314 1.00 20.07  ? 753  CYS A N   1 
ATOM   3606 C  CA  . CYS A 1 490 ? -30.650 -53.299 -11.645 1.00 18.42  ? 753  CYS A CA  1 
ATOM   3607 C  C   . CYS A 1 490 ? -29.353 -52.553 -12.047 1.00 19.77  ? 753  CYS A C   1 
ATOM   3608 O  O   . CYS A 1 490 ? -29.034 -52.543 -13.219 1.00 20.40  ? 753  CYS A O   1 
ATOM   3609 C  CB  . CYS A 1 490 ? -31.868 -52.395 -11.651 1.00 19.39  ? 753  CYS A CB  1 
ATOM   3610 S  SG  . CYS A 1 490 ? -33.404 -53.368 -11.575 1.00 23.51  ? 753  CYS A SG  1 
ATOM   3611 N  N   . LEU A 1 491 ? -28.616 -51.941 -11.117 1.00 18.87  ? 754  LEU A N   1 
ATOM   3612 C  CA  . LEU A 1 491 ? -27.284 -51.354 -11.412 1.00 18.92  ? 754  LEU A CA  1 
ATOM   3613 C  C   . LEU A 1 491 ? -26.276 -52.450 -11.774 1.00 20.26  ? 754  LEU A C   1 
ATOM   3614 O  O   . LEU A 1 491 ? -25.520 -52.274 -12.742 1.00 20.08  ? 754  LEU A O   1 
ATOM   3615 C  CB  . LEU A 1 491 ? -26.797 -50.533 -10.216 1.00 19.58  ? 754  LEU A CB  1 
ATOM   3616 C  CG  . LEU A 1 491 ? -25.441 -49.867 -10.441 1.00 22.46  ? 754  LEU A CG  1 
ATOM   3617 C  CD1 . LEU A 1 491 ? -25.490 -48.938 -11.651 1.00 23.08  ? 754  LEU A CD1 1 
ATOM   3618 C  CD2 . LEU A 1 491 ? -24.958 -49.144 -9.191  1.00 24.83  ? 754  LEU A CD2 1 
ATOM   3619 N  N   . GLY A 1 492 ? -26.302 -53.589 -11.084 1.00 19.86  ? 755  GLY A N   1 
ATOM   3620 C  CA  . GLY A 1 492 ? -25.453 -54.718 -11.474 1.00 18.53  ? 755  GLY A CA  1 
ATOM   3621 C  C   . GLY A 1 492 ? -25.738 -55.201 -12.874 1.00 18.62  ? 755  GLY A C   1 
ATOM   3622 O  O   . GLY A 1 492 ? -24.808 -55.463 -13.650 1.00 18.25  ? 755  GLY A O   1 
ATOM   3623 N  N   . LYS A 1 493 ? -27.018 -55.275 -13.228 1.00 17.92  ? 756  LYS A N   1 
ATOM   3624 C  CA  . LYS A 1 493 ? -27.450 -55.676 -14.567 1.00 17.96  ? 756  LYS A CA  1 
ATOM   3625 C  C   . LYS A 1 493 ? -26.980 -54.684 -15.621 1.00 17.16  ? 756  LYS A C   1 
ATOM   3626 O  O   . LYS A 1 493 ? -26.581 -55.154 -16.700 1.00 18.71  ? 756  LYS A O   1 
ATOM   3627 C  CB  . LYS A 1 493 ? -28.988 -55.815 -14.585 1.00 18.01  ? 756  LYS A CB  1 
ATOM   3628 C  CG  . LYS A 1 493 ? -29.498 -56.390 -15.893 1.00 20.11  ? 756  LYS A CG  1 
ATOM   3629 C  CD  . LYS A 1 493 ? -31.011 -56.704 -15.793 1.00 21.35  ? 756  LYS A CD  1 
ATOM   3630 C  CE  . LYS A 1 493 ? -31.583 -57.206 -17.092 1.00 23.82  ? 756  LYS A CE  1 
ATOM   3631 N  NZ  . LYS A 1 493 ? -32.973 -57.705 -16.916 1.00 24.43  ? 756  LYS A NZ  1 
ATOM   3632 N  N   . SER A 1 494 ? -26.975 -53.388 -15.349 1.00 18.80  ? 757  SER A N   1 
ATOM   3633 C  CA  . SER A 1 494 ? -26.407 -52.371 -16.271 1.00 19.66  ? 757  SER A CA  1 
ATOM   3634 C  C   . SER A 1 494 ? -24.930 -52.699 -16.571 1.00 19.60  ? 757  SER A C   1 
ATOM   3635 O  O   . SER A 1 494 ? -24.543 -52.730 -17.765 1.00 17.71  ? 757  SER A O   1 
ATOM   3636 C  CB  . SER A 1 494 ? -26.485 -50.958 -15.746 1.00 24.36  ? 757  SER A CB  1 
ATOM   3637 O  OG  . SER A 1 494 ? -27.833 -50.562 -15.520 1.00 31.14  ? 757  SER A OG  1 
ATOM   3638 N  N   . TYR A 1 495 ? -24.129 -52.930 -15.541 1.00 17.64  ? 758  TYR A N   1 
ATOM   3639 C  CA  . TYR A 1 495 ? -22.706 -53.297 -15.761 1.00 18.08  ? 758  TYR A CA  1 
ATOM   3640 C  C   . TYR A 1 495 ? -22.609 -54.570 -16.586 1.00 17.34  ? 758  TYR A C   1 
ATOM   3641 O  O   . TYR A 1 495 ? -21.764 -54.654 -17.516 1.00 18.95  ? 758  TYR A O   1 
ATOM   3642 C  CB  . TYR A 1 495 ? -21.932 -53.410 -14.435 1.00 17.95  ? 758  TYR A CB  1 
ATOM   3643 C  CG  . TYR A 1 495 ? -21.470 -52.077 -13.930 1.00 18.23  ? 758  TYR A CG  1 
ATOM   3644 C  CD1 . TYR A 1 495 ? -20.326 -51.491 -14.470 1.00 20.47  ? 758  TYR A CD1 1 
ATOM   3645 C  CD2 . TYR A 1 495 ? -22.146 -51.379 -12.947 1.00 20.48  ? 758  TYR A CD2 1 
ATOM   3646 C  CE1 . TYR A 1 495 ? -19.890 -50.255 -14.046 1.00 20.76  ? 758  TYR A CE1 1 
ATOM   3647 C  CE2 . TYR A 1 495 ? -21.687 -50.147 -12.485 1.00 22.54  ? 758  TYR A CE2 1 
ATOM   3648 C  CZ  . TYR A 1 495 ? -20.588 -49.555 -13.086 1.00 23.50  ? 758  TYR A CZ  1 
ATOM   3649 O  OH  . TYR A 1 495 ? -20.120 -48.317 -12.707 1.00 26.98  ? 758  TYR A OH  1 
ATOM   3650 N  N   . ALA A 1 496 ? -23.360 -55.605 -16.234 1.00 16.56  ? 759  ALA A N   1 
ATOM   3651 C  CA  . ALA A 1 496 ? -23.331 -56.905 -16.937 1.00 16.82  ? 759  ALA A CA  1 
ATOM   3652 C  C   . ALA A 1 496 ? -23.620 -56.715 -18.423 1.00 16.98  ? 759  ALA A C   1 
ATOM   3653 O  O   . ALA A 1 496 ? -22.919 -57.322 -19.258 1.00 17.65  ? 759  ALA A O   1 
ATOM   3654 C  CB  . ALA A 1 496 ? -24.290 -57.876 -16.296 1.00 19.17  ? 759  ALA A CB  1 
ATOM   3655 N  N   . GLN A 1 497 ? -24.668 -55.967 -18.753 1.00 18.01  ? 760  GLN A N   1 
ATOM   3656 C  CA  . GLN A 1 497 ? -25.059 -55.792 -20.167 1.00 18.61  ? 760  GLN A CA  1 
ATOM   3657 C  C   . GLN A 1 497 ? -24.002 -54.937 -20.906 1.00 18.09  ? 760  GLN A C   1 
ATOM   3658 O  O   . GLN A 1 497 ? -23.674 -55.286 -22.089 1.00 18.77  ? 760  GLN A O   1 
ATOM   3659 C  CB  . GLN A 1 497 ? -26.474 -55.241 -20.276 1.00 20.01  ? 760  GLN A CB  1 
ATOM   3660 C  CG  . GLN A 1 497 ? -27.492 -56.258 -19.753 1.00 21.45  ? 760  GLN A CG  1 
ATOM   3661 C  CD  . GLN A 1 497 ? -28.945 -56.017 -20.114 1.00 23.45  ? 760  GLN A CD  1 
ATOM   3662 O  OE1 . GLN A 1 497 ? -29.769 -56.950 -20.055 1.00 23.68  ? 760  GLN A OE1 1 
ATOM   3663 N  NE2 . GLN A 1 497 ? -29.255 -54.798 -20.472 1.00 22.78  ? 760  GLN A NE2 1 
ATOM   3664 N  N   . MET A 1 498 ? -23.374 -53.970 -20.226 1.00 18.34  ? 761  MET A N   1 
ATOM   3665 C  CA  . MET A 1 498 ? -22.231 -53.226 -20.824 1.00 18.97  ? 761  MET A CA  1 
ATOM   3666 C  C   . MET A 1 498 ? -21.109 -54.209 -21.117 1.00 17.99  ? 761  MET A C   1 
ATOM   3667 O  O   . MET A 1 498 ? -20.511 -54.180 -22.236 1.00 18.35  ? 761  MET A O   1 
ATOM   3668 C  CB  . MET A 1 498 ? -21.718 -52.100 -19.927 1.00 20.10  ? 761  MET A CB  1 
ATOM   3669 C  CG  . MET A 1 498 ? -20.452 -51.380 -20.478 1.00 23.71  ? 761  MET A CG  1 
ATOM   3670 S  SD  . MET A 1 498 ? -19.939 -50.124 -19.326 1.00 28.97  ? 761  MET A SD  1 
ATOM   3671 C  CE  . MET A 1 498 ? -19.001 -51.147 -18.201 1.00 26.32  ? 761  MET A CE  1 
ATOM   3672 N  N   . TRP A 1 499 ? -20.782 -55.084 -20.173 1.00 17.19  ? 762  TRP A N   1 
ATOM   3673 C  CA  . TRP A 1 499 ? -19.714 -56.076 -20.432 1.00 17.15  ? 762  TRP A CA  1 
ATOM   3674 C  C   . TRP A 1 499 ? -20.041 -56.984 -21.655 1.00 19.87  ? 762  TRP A C   1 
ATOM   3675 O  O   . TRP A 1 499 ? -19.163 -57.252 -22.441 1.00 18.56  ? 762  TRP A O   1 
ATOM   3676 C  CB  . TRP A 1 499 ? -19.478 -56.905 -19.176 1.00 17.56  ? 762  TRP A CB  1 
ATOM   3677 C  CG  . TRP A 1 499 ? -18.863 -56.184 -18.022 1.00 16.78  ? 762  TRP A CG  1 
ATOM   3678 C  CD1 . TRP A 1 499 ? -18.354 -54.925 -18.006 1.00 19.27  ? 762  TRP A CD1 1 
ATOM   3679 C  CD2 . TRP A 1 499 ? -18.669 -56.709 -16.692 1.00 17.24  ? 762  TRP A CD2 1 
ATOM   3680 N  NE1 . TRP A 1 499 ? -17.893 -54.623 -16.767 1.00 19.03  ? 762  TRP A NE1 1 
ATOM   3681 C  CE2 . TRP A 1 499 ? -18.044 -55.702 -15.946 1.00 17.85  ? 762  TRP A CE2 1 
ATOM   3682 C  CE3 . TRP A 1 499 ? -18.982 -57.908 -16.061 1.00 19.57  ? 762  TRP A CE3 1 
ATOM   3683 C  CZ2 . TRP A 1 499 ? -17.676 -55.871 -14.616 1.00 19.17  ? 762  TRP A CZ2 1 
ATOM   3684 C  CZ3 . TRP A 1 499 ? -18.683 -58.059 -14.721 1.00 20.34  ? 762  TRP A CZ3 1 
ATOM   3685 C  CH2 . TRP A 1 499 ? -18.050 -57.042 -14.013 1.00 19.30  ? 762  TRP A CH2 1 
ATOM   3686 N  N   A SER A 1 500 ? -21.289 -57.451 -21.770 0.25 19.01  ? 763  SER A N   1 
ATOM   3687 N  N   B SER A 1 500 ? -21.290 -57.455 -21.787 0.25 18.72  ? 763  SER A N   1 
ATOM   3688 C  CA  A SER A 1 500 ? -21.757 -58.318 -22.882 0.25 20.04  ? 763  SER A CA  1 
ATOM   3689 C  CA  B SER A 1 500 ? -21.717 -58.346 -22.899 0.25 19.52  ? 763  SER A CA  1 
ATOM   3690 C  C   A SER A 1 500 ? -21.636 -57.597 -24.230 0.25 18.90  ? 763  SER A C   1 
ATOM   3691 C  C   B SER A 1 500 ? -21.667 -57.603 -24.241 0.25 18.24  ? 763  SER A C   1 
ATOM   3692 O  O   A SER A 1 500 ? -21.400 -58.289 -25.257 0.25 21.79  ? 763  SER A O   1 
ATOM   3693 O  O   B SER A 1 500 ? -21.546 -58.300 -25.291 0.25 18.92  ? 763  SER A O   1 
ATOM   3694 C  CB  A SER A 1 500 ? -23.175 -58.757 -22.670 0.25 20.70  ? 763  SER A CB  1 
ATOM   3695 C  CB  B SER A 1 500 ? -23.100 -58.911 -22.700 0.25 20.18  ? 763  SER A CB  1 
ATOM   3696 O  OG  A SER A 1 500 ? -23.281 -59.481 -21.456 0.25 22.93  ? 763  SER A OG  1 
ATOM   3697 O  OG  B SER A 1 500 ? -24.076 -57.916 -22.934 0.25 21.94  ? 763  SER A OG  1 
ATOM   3698 N  N   . LEU A 1 501 ? -21.790 -56.269 -24.242 1.00 20.15  ? 764  LEU A N   1 
ATOM   3699 C  CA  . LEU A 1 501 ? -21.712 -55.479 -25.501 1.00 22.86  ? 764  LEU A CA  1 
ATOM   3700 C  C   . LEU A 1 501 ? -20.285 -55.012 -25.839 1.00 24.12  ? 764  LEU A C   1 
ATOM   3701 O  O   . LEU A 1 501 ? -19.918 -55.001 -27.035 1.00 24.59  ? 764  LEU A O   1 
ATOM   3702 C  CB  . LEU A 1 501 ? -22.705 -54.324 -25.406 1.00 25.92  ? 764  LEU A CB  1 
ATOM   3703 C  CG  . LEU A 1 501 ? -23.038 -53.688 -26.740 1.00 33.76  ? 764  LEU A CG  1 
ATOM   3704 C  CD1 . LEU A 1 501 ? -23.585 -54.738 -27.714 1.00 38.23  ? 764  LEU A CD1 1 
ATOM   3705 C  CD2 . LEU A 1 501 ? -24.066 -52.572 -26.517 1.00 37.69  ? 764  LEU A CD2 1 
ATOM   3706 N  N   . MET A 1 502 ? -19.483 -54.588 -24.862 1.00 20.74  ? 765  MET A N   1 
ATOM   3707 C  CA  . MET A 1 502 ? -18.206 -53.900 -25.109 1.00 20.58  ? 765  MET A CA  1 
ATOM   3708 C  C   . MET A 1 502 ? -17.045 -54.859 -24.812 1.00 21.03  ? 765  MET A C   1 
ATOM   3709 O  O   . MET A 1 502 ? -16.051 -54.734 -25.498 1.00 18.03  ? 765  MET A O   1 
ATOM   3710 C  CB  . MET A 1 502 ? -18.089 -52.671 -24.212 1.00 21.99  ? 765  MET A CB  1 
ATOM   3711 C  CG  . MET A 1 502 ? -19.190 -51.644 -24.428 1.00 25.68  ? 765  MET A CG  1 
ATOM   3712 S  SD  . MET A 1 502 ? -19.033 -50.945 -26.108 1.00 31.17  ? 765  MET A SD  1 
ATOM   3713 C  CE  . MET A 1 502 ? -20.326 -51.774 -26.979 1.00 35.30  ? 765  MET A CE  1 
ATOM   3714 N  N   . TYR A 1 503 ? -17.181 -55.758 -23.834 1.00 18.03  ? 766  TYR A N   1 
ATOM   3715 C  CA  . TYR A 1 503 ? -16.038 -56.541 -23.297 1.00 17.76  ? 766  TYR A CA  1 
ATOM   3716 C  C   . TYR A 1 503 ? -16.291 -58.054 -23.369 1.00 19.17  ? 766  TYR A C   1 
ATOM   3717 O  O   . TYR A 1 503 ? -15.697 -58.834 -22.590 1.00 17.32  ? 766  TYR A O   1 
ATOM   3718 C  CB  . TYR A 1 503 ? -15.724 -56.081 -21.882 1.00 19.23  ? 766  TYR A CB  1 
ATOM   3719 C  CG  . TYR A 1 503 ? -15.542 -54.594 -21.699 1.00 20.21  ? 766  TYR A CG  1 
ATOM   3720 C  CD1 . TYR A 1 503 ? -14.536 -53.886 -22.350 1.00 19.30  ? 766  TYR A CD1 1 
ATOM   3721 C  CD2 . TYR A 1 503 ? -16.335 -53.887 -20.818 1.00 23.51  ? 766  TYR A CD2 1 
ATOM   3722 C  CE1 . TYR A 1 503 ? -14.394 -52.522 -22.162 1.00 19.58  ? 766  TYR A CE1 1 
ATOM   3723 C  CE2 . TYR A 1 503 ? -16.221 -52.517 -20.646 1.00 23.87  ? 766  TYR A CE2 1 
ATOM   3724 C  CZ  . TYR A 1 503 ? -15.218 -51.827 -21.295 1.00 21.34  ? 766  TYR A CZ  1 
ATOM   3725 O  OH  . TYR A 1 503 ? -15.077 -50.480 -21.092 1.00 21.48  ? 766  TYR A OH  1 
ATOM   3726 N  N   . PHE A 1 504 ? -17.152 -58.481 -24.306 1.00 17.82  ? 767  PHE A N   1 
ATOM   3727 C  CA  . PHE A 1 504 ? -17.514 -59.889 -24.563 1.00 18.59  ? 767  PHE A CA  1 
ATOM   3728 C  C   . PHE A 1 504 ? -16.286 -60.764 -24.838 1.00 19.22  ? 767  PHE A C   1 
ATOM   3729 O  O   . PHE A 1 504 ? -16.354 -61.992 -24.662 1.00 18.42  ? 767  PHE A O   1 
ATOM   3730 C  CB  . PHE A 1 504 ? -18.466 -60.004 -25.770 1.00 19.30  ? 767  PHE A CB  1 
ATOM   3731 C  CG  . PHE A 1 504 ? -17.970 -59.286 -26.994 1.00 18.38  ? 767  PHE A CG  1 
ATOM   3732 C  CD1 . PHE A 1 504 ? -17.171 -59.933 -27.915 1.00 20.44  ? 767  PHE A CD1 1 
ATOM   3733 C  CD2 . PHE A 1 504 ? -18.288 -57.952 -27.190 1.00 19.37  ? 767  PHE A CD2 1 
ATOM   3734 C  CE1 . PHE A 1 504 ? -16.688 -59.236 -29.001 1.00 19.71  ? 767  PHE A CE1 1 
ATOM   3735 C  CE2 . PHE A 1 504 ? -17.813 -57.267 -28.289 1.00 20.92  ? 767  PHE A CE2 1 
ATOM   3736 C  CZ  . PHE A 1 504 ? -17.034 -57.926 -29.186 1.00 20.00  ? 767  PHE A CZ  1 
ATOM   3737 N  N   . HIS A 1 505 ? -15.217 -60.127 -25.319 1.00 19.07  ? 768  HIS A N   1 
ATOM   3738 C  CA  . HIS A 1 505 ? -13.962 -60.781 -25.743 1.00 18.40  ? 768  HIS A CA  1 
ATOM   3739 C  C   . HIS A 1 505 ? -13.075 -61.142 -24.539 1.00 18.65  ? 768  HIS A C   1 
ATOM   3740 O  O   . HIS A 1 505 ? -12.029 -61.772 -24.750 1.00 18.21  ? 768  HIS A O   1 
ATOM   3741 C  CB  . HIS A 1 505 ? -13.257 -59.900 -26.767 1.00 18.28  ? 768  HIS A CB  1 
ATOM   3742 C  CG  . HIS A 1 505 ? -13.090 -58.496 -26.309 1.00 19.02  ? 768  HIS A CG  1 
ATOM   3743 N  ND1 . HIS A 1 505 ? -12.004 -58.098 -25.574 1.00 17.53  ? 768  HIS A ND1 1 
ATOM   3744 C  CD2 . HIS A 1 505 ? -13.877 -57.406 -26.484 1.00 18.08  ? 768  HIS A CD2 1 
ATOM   3745 C  CE1 . HIS A 1 505 ? -12.140 -56.818 -25.299 1.00 17.24  ? 768  HIS A CE1 1 
ATOM   3746 N  NE2 . HIS A 1 505 ? -13.317 -56.350 -25.824 1.00 18.74  ? 768  HIS A NE2 1 
ATOM   3747 N  N   . ARG A 1 506 ? -13.461 -60.729 -23.324 1.00 16.75  ? 769  ARG A N   1 
ATOM   3748 C  CA  . ARG A 1 506 ? -12.740 -61.045 -22.057 1.00 16.95  ? 769  ARG A CA  1 
ATOM   3749 C  C   . ARG A 1 506 ? -13.476 -62.222 -21.412 1.00 17.27  ? 769  ARG A C   1 
ATOM   3750 O  O   . ARG A 1 506 ? -14.677 -62.037 -21.091 1.00 18.16  ? 769  ARG A O   1 
ATOM   3751 C  CB  . ARG A 1 506 ? -12.709 -59.820 -21.137 1.00 16.03  ? 769  ARG A CB  1 
ATOM   3752 C  CG  . ARG A 1 506 ? -12.238 -58.527 -21.776 1.00 17.15  ? 769  ARG A CG  1 
ATOM   3753 C  CD  . ARG A 1 506 ? -10.862 -58.628 -22.457 1.00 16.81  ? 769  ARG A CD  1 
ATOM   3754 N  NE  . ARG A 1 506 ? -9.874  -59.166 -21.520 1.00 17.31  ? 769  ARG A NE  1 
ATOM   3755 C  CZ  . ARG A 1 506 ? -9.342  -58.511 -20.499 1.00 18.57  ? 769  ARG A CZ  1 
ATOM   3756 N  NH1 . ARG A 1 506 ? -8.608  -59.174 -19.610 1.00 17.61  ? 769  ARG A NH1 1 
ATOM   3757 N  NH2 . ARG A 1 506 ? -9.486  -57.199 -20.363 1.00 18.10  ? 769  ARG A NH2 1 
ATOM   3758 N  N   . ARG A 1 507 ? -12.838 -63.397 -21.359 1.00 17.93  ? 770  ARG A N   1 
ATOM   3759 C  CA  . ARG A 1 507 ? -13.466 -64.632 -20.831 1.00 19.63  ? 770  ARG A CA  1 
ATOM   3760 C  C   . ARG A 1 507 ? -14.170 -64.368 -19.492 1.00 17.61  ? 770  ARG A C   1 
ATOM   3761 O  O   . ARG A 1 507 ? -15.352 -64.792 -19.352 1.00 19.05  ? 770  ARG A O   1 
ATOM   3762 C  CB  . ARG A 1 507 ? -12.448 -65.776 -20.691 1.00 20.10  ? 770  ARG A CB  1 
ATOM   3763 C  CG  . ARG A 1 507 ? -11.935 -66.291 -22.029 1.00 20.96  ? 770  ARG A CG  1 
ATOM   3764 C  CD  . ARG A 1 507 ? -10.676 -67.153 -21.912 1.00 23.86  ? 770  ARG A CD  1 
ATOM   3765 N  NE  . ARG A 1 507 ? -10.315 -67.667 -23.244 1.00 24.35  ? 770  ARG A NE  1 
ATOM   3766 C  CZ  . ARG A 1 507 ? -9.751  -66.934 -24.185 1.00 24.91  ? 770  ARG A CZ  1 
ATOM   3767 N  NH1 . ARG A 1 507 ? -9.394  -65.677 -23.946 1.00 21.00  ? 770  ARG A NH1 1 
ATOM   3768 N  NH2 . ARG A 1 507 ? -9.517  -67.463 -25.378 1.00 24.11  ? 770  ARG A NH2 1 
ATOM   3769 N  N   . ASP A 1 508 ? -13.502 -63.755 -18.515 1.00 16.45  ? 771  ASP A N   1 
ATOM   3770 C  CA  . ASP A 1 508 ? -14.040 -63.601 -17.155 1.00 18.78  ? 771  ASP A CA  1 
ATOM   3771 C  C   . ASP A 1 508 ? -15.278 -62.693 -17.194 1.00 20.42  ? 771  ASP A C   1 
ATOM   3772 O  O   . ASP A 1 508 ? -16.211 -62.944 -16.402 1.00 18.19  ? 771  ASP A O   1 
ATOM   3773 C  CB  . ASP A 1 508 ? -13.016 -63.009 -16.204 1.00 17.69  ? 771  ASP A CB  1 
ATOM   3774 C  CG  . ASP A 1 508 ? -11.797 -63.895 -15.978 1.00 19.38  ? 771  ASP A CG  1 
ATOM   3775 O  OD1 . ASP A 1 508 ? -11.839 -65.074 -16.391 1.00 19.46  ? 771  ASP A OD1 1 
ATOM   3776 O  OD2 . ASP A 1 508 ? -10.809 -63.349 -15.480 1.00 18.25  ? 771  ASP A OD2 1 
ATOM   3777 N  N   . LEU A 1 509 ? -15.287 -61.662 -18.055 1.00 17.50  ? 772  LEU A N   1 
ATOM   3778 C  CA  . LEU A 1 509 ? -16.402 -60.680 -18.047 1.00 18.12  ? 772  LEU A CA  1 
ATOM   3779 C  C   . LEU A 1 509 ? -17.582 -61.297 -18.770 1.00 18.32  ? 772  LEU A C   1 
ATOM   3780 O  O   . LEU A 1 509 ? -18.734 -61.010 -18.366 1.00 18.81  ? 772  LEU A O   1 
ATOM   3781 C  CB  . LEU A 1 509 ? -15.980 -59.338 -18.650 1.00 18.35  ? 772  LEU A CB  1 
ATOM   3782 C  CG  . LEU A 1 509 ? -14.813 -58.636 -17.921 1.00 18.12  ? 772  LEU A CG  1 
ATOM   3783 C  CD1 . LEU A 1 509 ? -14.581 -57.242 -18.510 1.00 20.31  ? 772  LEU A CD1 1 
ATOM   3784 C  CD2 . LEU A 1 509 ? -15.091 -58.529 -16.414 1.00 20.56  ? 772  LEU A CD2 1 
ATOM   3785 N  N   . ARG A 1 510 ? -17.373 -62.102 -19.805 1.00 17.74  ? 773  ARG A N   1 
ATOM   3786 C  CA  . ARG A 1 510 ? -18.555 -62.700 -20.488 1.00 18.98  ? 773  ARG A CA  1 
ATOM   3787 C  C   . ARG A 1 510 ? -19.212 -63.663 -19.492 1.00 20.20  ? 773  ARG A C   1 
ATOM   3788 O  O   . ARG A 1 510 ? -20.462 -63.711 -19.428 1.00 19.35  ? 773  ARG A O   1 
ATOM   3789 C  CB  . ARG A 1 510 ? -18.242 -63.401 -21.803 1.00 18.89  ? 773  ARG A CB  1 
ATOM   3790 C  CG  . ARG A 1 510 ? -19.487 -63.686 -22.641 1.00 20.33  ? 773  ARG A CG  1 
ATOM   3791 C  CD  . ARG A 1 510 ? -19.283 -64.578 -23.830 1.00 20.26  ? 773  ARG A CD  1 
ATOM   3792 N  NE  . ARG A 1 510 ? -18.342 -64.027 -24.777 1.00 19.51  ? 773  ARG A NE  1 
ATOM   3793 C  CZ  . ARG A 1 510 ? -18.168 -64.480 -26.005 1.00 20.60  ? 773  ARG A CZ  1 
ATOM   3794 N  NH1 . ARG A 1 510 ? -18.981 -65.402 -26.517 1.00 21.74  ? 773  ARG A NH1 1 
ATOM   3795 N  NH2 . ARG A 1 510 ? -17.271 -63.910 -26.778 1.00 20.25  ? 773  ARG A NH2 1 
ATOM   3796 N  N   . LEU A 1 511 ? -18.412 -64.425 -18.743 1.00 19.28  ? 774  LEU A N   1 
ATOM   3797 C  CA  . LEU A 1 511 ? -18.950 -65.387 -17.753 1.00 19.66  ? 774  LEU A CA  1 
ATOM   3798 C  C   . LEU A 1 511 ? -19.670 -64.628 -16.635 1.00 18.60  ? 774  LEU A C   1 
ATOM   3799 O  O   . LEU A 1 511 ? -20.837 -64.974 -16.292 1.00 17.69  ? 774  LEU A O   1 
ATOM   3800 C  CB  . LEU A 1 511 ? -17.798 -66.254 -17.208 1.00 20.30  ? 774  LEU A CB  1 
ATOM   3801 C  CG  . LEU A 1 511 ? -18.217 -67.543 -16.496 1.00 22.64  ? 774  LEU A CG  1 
ATOM   3802 C  CD1 . LEU A 1 511 ? -17.050 -68.509 -16.409 1.00 22.91  ? 774  LEU A CD1 1 
ATOM   3803 C  CD2 . LEU A 1 511 ? -18.758 -67.316 -15.097 1.00 22.98  ? 774  LEU A CD2 1 
ATOM   3804 N  N   . ALA A 1 512 ? -19.048 -63.616 -16.053 1.00 18.53  ? 775  ALA A N   1 
ATOM   3805 C  CA  . ALA A 1 512 ? -19.630 -62.862 -14.908 1.00 17.66  ? 775  ALA A CA  1 
ATOM   3806 C  C   . ALA A 1 512 ? -20.896 -62.124 -15.391 1.00 18.93  ? 775  ALA A C   1 
ATOM   3807 O  O   . ALA A 1 512 ? -21.880 -62.064 -14.637 1.00 18.43  ? 775  ALA A O   1 
ATOM   3808 C  CB  . ALA A 1 512 ? -18.631 -61.891 -14.331 1.00 17.47  ? 775  ALA A CB  1 
ATOM   3809 N  N   . ALA A 1 513 ? -20.890 -61.607 -16.616 1.00 17.86  ? 776  ALA A N   1 
ATOM   3810 C  CA  . ALA A 1 513 ? -22.078 -60.918 -17.188 1.00 18.90  ? 776  ALA A CA  1 
ATOM   3811 C  C   . ALA A 1 513 ? -23.244 -61.898 -17.289 1.00 18.54  ? 776  ALA A C   1 
ATOM   3812 O  O   . ALA A 1 513 ? -24.371 -61.554 -16.851 1.00 18.43  ? 776  ALA A O   1 
ATOM   3813 C  CB  . ALA A 1 513 ? -21.767 -60.325 -18.537 1.00 18.53  ? 776  ALA A CB  1 
ATOM   3814 N  N   . ASN A 1 514 ? -22.990 -63.060 -17.859 1.00 17.84  ? 777  ASN A N   1 
ATOM   3815 C  CA  . ASN A 1 514 ? -24.045 -64.120 -17.928 1.00 19.75  ? 777  ASN A CA  1 
ATOM   3816 C  C   . ASN A 1 514 ? -24.532 -64.475 -16.522 1.00 18.49  ? 777  ASN A C   1 
ATOM   3817 O  O   . ASN A 1 514 ? -25.784 -64.603 -16.324 1.00 20.34  ? 777  ASN A O   1 
ATOM   3818 C  CB  . ASN A 1 514 ? -23.519 -65.318 -18.688 1.00 20.41  ? 777  ASN A CB  1 
ATOM   3819 C  CG  . ASN A 1 514 ? -23.464 -65.014 -20.173 1.00 25.52  ? 777  ASN A CG  1 
ATOM   3820 O  OD1 . ASN A 1 514 ? -24.306 -64.307 -20.713 1.00 30.30  ? 777  ASN A OD1 1 
ATOM   3821 N  ND2 . ASN A 1 514 ? -22.487 -65.589 -20.838 1.00 29.41  ? 777  ASN A ND2 1 
ATOM   3822 N  N   . ALA A 1 515 ? -23.642 -64.617 -15.546 1.00 18.96  ? 778  ALA A N   1 
ATOM   3823 C  CA  . ALA A 1 515 ? -24.042 -64.958 -14.163 1.00 19.12  ? 778  ALA A CA  1 
ATOM   3824 C  C   . ALA A 1 515 ? -24.949 -63.852 -13.597 1.00 19.05  ? 778  ALA A C   1 
ATOM   3825 O  O   . ALA A 1 515 ? -25.984 -64.170 -13.009 1.00 20.29  ? 778  ALA A O   1 
ATOM   3826 C  CB  . ALA A 1 515 ? -22.848 -65.227 -13.287 1.00 19.12  ? 778  ALA A CB  1 
ATOM   3827 N  N   . ILE A 1 516 ? -24.564 -62.582 -13.713 1.00 18.28  ? 779  ILE A N   1 
ATOM   3828 C  CA  . ILE A 1 516 ? -25.344 -61.471 -13.123 1.00 17.31  ? 779  ILE A CA  1 
ATOM   3829 C  C   . ILE A 1 516 ? -26.719 -61.456 -13.815 1.00 19.42  ? 779  ILE A C   1 
ATOM   3830 O  O   . ILE A 1 516 ? -27.729 -61.350 -13.126 1.00 20.30  ? 779  ILE A O   1 
ATOM   3831 C  CB  . ILE A 1 516 ? -24.621 -60.118 -13.301 1.00 18.10  ? 779  ILE A CB  1 
ATOM   3832 C  CG1 . ILE A 1 516 ? -23.359 -60.087 -12.449 1.00 17.76  ? 779  ILE A CG1 1 
ATOM   3833 C  CG2 . ILE A 1 516 ? -25.547 -58.951 -12.976 1.00 18.38  ? 779  ILE A CG2 1 
ATOM   3834 C  CD1 . ILE A 1 516 ? -22.329 -58.995 -12.888 1.00 19.72  ? 779  ILE A CD1 1 
ATOM   3835 N  N   . CYS A 1 517 ? -26.756 -61.549 -15.136 1.00 18.26  ? 780  CYS A N   1 
ATOM   3836 C  CA  . CYS A 1 517 ? -28.059 -61.508 -15.883 1.00 18.54  ? 780  CYS A CA  1 
ATOM   3837 C  C   . CYS A 1 517 ? -28.914 -62.720 -15.498 1.00 22.03  ? 780  CYS A C   1 
ATOM   3838 O  O   . CYS A 1 517 ? -30.168 -62.624 -15.603 1.00 22.80  ? 780  CYS A O   1 
ATOM   3839 C  CB  . CYS A 1 517 ? -27.839 -61.388 -17.376 1.00 21.53  ? 780  CYS A CB  1 
ATOM   3840 S  SG  . CYS A 1 517 ? -27.192 -59.753 -17.823 1.00 24.84  ? 780  CYS A SG  1 
ATOM   3841 N  N   . SER A 1 518 ? -28.305 -63.820 -15.070 1.00 19.76  ? 781  SER A N   1 
ATOM   3842 C  CA  . SER A 1 518 ? -29.047 -65.041 -14.649 1.00 20.76  ? 781  SER A CA  1 
ATOM   3843 C  C   . SER A 1 518 ? -29.589 -64.808 -13.240 1.00 22.83  ? 781  SER A C   1 
ATOM   3844 O  O   . SER A 1 518 ? -30.610 -65.459 -12.880 1.00 21.31  ? 781  SER A O   1 
ATOM   3845 C  CB  . SER A 1 518 ? -28.220 -66.297 -14.692 1.00 22.23  ? 781  SER A CB  1 
ATOM   3846 O  OG  . SER A 1 518 ? -27.755 -66.571 -16.003 1.00 23.31  ? 781  SER A OG  1 
ATOM   3847 N  N   . ALA A 1 519 ? -28.901 -63.996 -12.431 1.00 19.60  ? 782  ALA A N   1 
ATOM   3848 C  CA  . ALA A 1 519 ? -29.201 -63.811 -10.993 1.00 18.98  ? 782  ALA A CA  1 
ATOM   3849 C  C   . ALA A 1 519 ? -30.221 -62.710 -10.753 1.00 19.28  ? 782  ALA A C   1 
ATOM   3850 O  O   . ALA A 1 519 ? -30.730 -62.660 -9.642  1.00 22.82  ? 782  ALA A O   1 
ATOM   3851 C  CB  . ALA A 1 519 ? -27.934 -63.568 -10.199 1.00 18.61  ? 782  ALA A CB  1 
ATOM   3852 N  N   . VAL A 1 520 ? -30.416 -61.807 -11.711 1.00 20.28  ? 783  VAL A N   1 
ATOM   3853 C  CA  . VAL A 1 520 ? -31.329 -60.657 -11.584 1.00 21.18  ? 783  VAL A CA  1 
ATOM   3854 C  C   . VAL A 1 520 ? -32.589 -61.022 -12.367 1.00 21.52  ? 783  VAL A C   1 
ATOM   3855 O  O   . VAL A 1 520 ? -32.508 -61.537 -13.488 1.00 20.73  ? 783  VAL A O   1 
ATOM   3856 C  CB  . VAL A 1 520 ? -30.652 -59.372 -12.108 1.00 22.34  ? 783  VAL A CB  1 
ATOM   3857 C  CG1 . VAL A 1 520 ? -31.622 -58.206 -12.101 1.00 22.42  ? 783  VAL A CG1 1 
ATOM   3858 C  CG2 . VAL A 1 520 ? -29.429 -59.025 -11.243 1.00 20.72  ? 783  VAL A CG2 1 
ATOM   3859 N  N   . PRO A 1 521 ? -33.812 -60.775 -11.826 1.00 21.19  ? 784  PRO A N   1 
ATOM   3860 C  CA  . PRO A 1 521 ? -35.008 -61.125 -12.584 1.00 22.96  ? 784  PRO A CA  1 
ATOM   3861 C  C   . PRO A 1 521 ? -34.968 -60.603 -14.031 1.00 23.35  ? 784  PRO A C   1 
ATOM   3862 O  O   . PRO A 1 521 ? -34.605 -59.459 -14.273 1.00 22.10  ? 784  PRO A O   1 
ATOM   3863 C  CB  . PRO A 1 521 ? -36.133 -60.505 -11.718 1.00 21.13  ? 784  PRO A CB  1 
ATOM   3864 C  CG  . PRO A 1 521 ? -35.605 -60.615 -10.301 1.00 22.72  ? 784  PRO A CG  1 
ATOM   3865 C  CD  . PRO A 1 521 ? -34.121 -60.253 -10.482 1.00 22.01  ? 784  PRO A CD  1 
ATOM   3866 N  N   A SER A 1 522 ? -35.372 -61.451 -14.977 0.25 24.71  ? 785  SER A N   1 
ATOM   3867 N  N   B SER A 1 522 ? -35.395 -61.466 -14.961 0.25 24.55  ? 785  SER A N   1 
ATOM   3868 C  CA  A SER A 1 522 ? -35.195 -61.237 -16.437 0.25 26.76  ? 785  SER A CA  1 
ATOM   3869 C  CA  B SER A 1 522 ? -35.282 -61.297 -16.434 0.25 26.53  ? 785  SER A CA  1 
ATOM   3870 C  C   A SER A 1 522 ? -35.850 -59.926 -16.895 0.25 26.25  ? 785  SER A C   1 
ATOM   3871 C  C   B SER A 1 522 ? -35.854 -59.948 -16.880 0.25 26.13  ? 785  SER A C   1 
ATOM   3872 O  O   A SER A 1 522 ? -35.267 -59.273 -17.770 0.25 24.59  ? 785  SER A O   1 
ATOM   3873 O  O   B SER A 1 522 ? -35.224 -59.304 -17.726 0.25 24.63  ? 785  SER A O   1 
ATOM   3874 C  CB  A SER A 1 522 ? -35.723 -62.414 -17.210 0.25 29.56  ? 785  SER A CB  1 
ATOM   3875 C  CB  B SER A 1 522 ? -35.960 -62.438 -17.168 0.25 29.05  ? 785  SER A CB  1 
ATOM   3876 O  OG  A SER A 1 522 ? -37.137 -62.455 -17.123 0.25 31.33  ? 785  SER A OG  1 
ATOM   3877 O  OG  B SER A 1 522 ? -36.016 -63.607 -16.366 0.25 30.02  ? 785  SER A OG  1 
ATOM   3878 N  N   . HIS A 1 523 ? -37.017 -59.542 -16.342 1.00 26.51  ? 786  HIS A N   1 
ATOM   3879 C  CA  . HIS A 1 523 ? -37.745 -58.318 -16.793 1.00 24.16  ? 786  HIS A CA  1 
ATOM   3880 C  C   . HIS A 1 523 ? -37.374 -57.053 -16.024 1.00 24.08  ? 786  HIS A C   1 
ATOM   3881 O  O   . HIS A 1 523 ? -37.845 -55.956 -16.398 1.00 26.96  ? 786  HIS A O   1 
ATOM   3882 C  CB  . HIS A 1 523 ? -39.268 -58.582 -16.796 1.00 24.67  ? 786  HIS A CB  1 
ATOM   3883 C  CG  . HIS A 1 523 ? -39.668 -59.704 -17.695 1.00 26.22  ? 786  HIS A CG  1 
ATOM   3884 N  ND1 . HIS A 1 523 ? -39.770 -59.533 -19.063 1.00 32.05  ? 786  HIS A ND1 1 
ATOM   3885 C  CD2 . HIS A 1 523 ? -39.945 -61.003 -17.454 1.00 35.35  ? 786  HIS A CD2 1 
ATOM   3886 C  CE1 . HIS A 1 523 ? -40.115 -60.684 -19.627 1.00 35.04  ? 786  HIS A CE1 1 
ATOM   3887 N  NE2 . HIS A 1 523 ? -40.241 -61.608 -18.668 1.00 33.32  ? 786  HIS A NE2 1 
ATOM   3888 N  N   . TRP A 1 524 ? -36.513 -57.128 -15.006 1.00 22.39  ? 787  TRP A N   1 
ATOM   3889 C  CA  . TRP A 1 524 ? -36.131 -55.915 -14.249 1.00 22.84  ? 787  TRP A CA  1 
ATOM   3890 C  C   . TRP A 1 524 ? -35.252 -55.031 -15.132 1.00 22.87  ? 787  TRP A C   1 
ATOM   3891 O  O   . TRP A 1 524 ? -34.403 -55.563 -15.861 1.00 25.48  ? 787  TRP A O   1 
ATOM   3892 C  CB  . TRP A 1 524 ? -35.500 -56.266 -12.893 1.00 22.30  ? 787  TRP A CB  1 
ATOM   3893 C  CG  . TRP A 1 524 ? -36.500 -56.715 -11.859 1.00 23.82  ? 787  TRP A CG  1 
ATOM   3894 C  CD1 . TRP A 1 524 ? -37.822 -57.035 -12.027 1.00 24.00  ? 787  TRP A CD1 1 
ATOM   3895 C  CD2 . TRP A 1 524 ? -36.208 -56.989 -10.474 1.00 23.18  ? 787  TRP A CD2 1 
ATOM   3896 N  NE1 . TRP A 1 524 ? -38.373 -57.463 -10.842 1.00 23.42  ? 787  TRP A NE1 1 
ATOM   3897 C  CE2 . TRP A 1 524 ? -37.415 -57.403 -9.859  1.00 23.98  ? 787  TRP A CE2 1 
ATOM   3898 C  CE3 . TRP A 1 524 ? -35.045 -56.898 -9.700  1.00 25.54  ? 787  TRP A CE3 1 
ATOM   3899 C  CZ2 . TRP A 1 524 ? -37.475 -57.751 -8.511  1.00 26.05  ? 787  TRP A CZ2 1 
ATOM   3900 C  CZ3 . TRP A 1 524 ? -35.129 -57.217 -8.355  1.00 26.17  ? 787  TRP A CZ3 1 
ATOM   3901 C  CH2 . TRP A 1 524 ? -36.325 -57.608 -7.769  1.00 23.42  ? 787  TRP A CH2 1 
ATOM   3902 N  N   . VAL A 1 525 ? -35.487 -53.734 -15.091 1.00 23.59  ? 788  VAL A N   1 
ATOM   3903 C  CA  . VAL A 1 525 ? -34.909 -52.786 -16.081 1.00 25.14  ? 788  VAL A CA  1 
ATOM   3904 C  C   . VAL A 1 525 ? -33.570 -52.305 -15.541 1.00 24.94  ? 788  VAL A C   1 
ATOM   3905 O  O   . VAL A 1 525 ? -33.486 -51.742 -14.460 1.00 25.42  ? 788  VAL A O   1 
ATOM   3906 C  CB  . VAL A 1 525 ? -35.867 -51.608 -16.311 1.00 29.46  ? 788  VAL A CB  1 
ATOM   3907 C  CG1 . VAL A 1 525 ? -35.273 -50.555 -17.251 1.00 31.25  ? 788  VAL A CG1 1 
ATOM   3908 C  CG2 . VAL A 1 525 ? -37.229 -52.103 -16.804 1.00 30.46  ? 788  VAL A CG2 1 
ATOM   3909 N  N   . PRO A 1 526 ? -32.486 -52.396 -16.309 1.00 27.48  ? 789  PRO A N   1 
ATOM   3910 C  CA  . PRO A 1 526 ? -31.229 -51.807 -15.854 1.00 25.71  ? 789  PRO A CA  1 
ATOM   3911 C  C   . PRO A 1 526 ? -31.317 -50.311 -15.558 1.00 28.57  ? 789  PRO A C   1 
ATOM   3912 O  O   . PRO A 1 526 ? -31.998 -49.575 -16.283 1.00 26.57  ? 789  PRO A O   1 
ATOM   3913 C  CB  . PRO A 1 526 ? -30.268 -51.995 -17.035 1.00 26.35  ? 789  PRO A CB  1 
ATOM   3914 C  CG  . PRO A 1 526 ? -30.927 -52.918 -17.995 1.00 27.54  ? 789  PRO A CG  1 
ATOM   3915 C  CD  . PRO A 1 526 ? -32.393 -52.996 -17.644 1.00 25.88  ? 789  PRO A CD  1 
ATOM   3916 N  N   . THR A 1 527 ? -30.609 -49.875 -14.515 1.00 29.84  ? 790  THR A N   1 
ATOM   3917 C  CA  . THR A 1 527 ? -30.623 -48.476 -14.036 1.00 35.55  ? 790  THR A CA  1 
ATOM   3918 C  C   . THR A 1 527 ? -29.216 -48.007 -13.737 1.00 40.02  ? 790  THR A C   1 
ATOM   3919 O  O   . THR A 1 527 ? -28.273 -48.833 -13.636 1.00 36.65  ? 790  THR A O   1 
ATOM   3920 C  CB  . THR A 1 527 ? -31.431 -48.255 -12.742 1.00 43.66  ? 790  THR A CB  1 
ATOM   3921 O  OG1 . THR A 1 527 ? -30.938 -49.072 -11.660 1.00 52.40  ? 790  THR A OG1 1 
ATOM   3922 C  CG2 . THR A 1 527 ? -32.899 -48.471 -12.972 1.00 50.52  ? 790  THR A CG2 1 
ATOM   3923 N  N   . SER A 1 528 ? -29.109 -46.697 -13.711 1.00 37.86  ? 791  SER A N   1 
ATOM   3924 C  CA  . SER A 1 528 ? -27.927 -45.909 -13.300 1.00 51.42  ? 791  SER A CA  1 
ATOM   3925 C  C   . SER A 1 528 ? -28.490 -44.634 -12.678 1.00 56.18  ? 791  SER A C   1 
ATOM   3926 O  O   . SER A 1 528 ? -29.609 -44.264 -13.094 1.00 59.64  ? 791  SER A O   1 
ATOM   3927 C  CB  . SER A 1 528 ? -27.066 -45.625 -14.494 1.00 51.96  ? 791  SER A CB  1 
ATOM   3928 O  OG  . SER A 1 528 ? -25.861 -45.006 -14.085 1.00 67.23  ? 791  SER A OG  1 
ATOM   3929 N  N   . ARG A 1 529 ? -27.802 -44.017 -11.716 1.00 64.63  ? 792  ARG A N   1 
ATOM   3930 C  CA  . ARG A 1 529 ? -28.180 -42.679 -11.173 1.00 66.77  ? 792  ARG A CA  1 
ATOM   3931 C  C   . ARG A 1 529 ? -27.456 -41.567 -11.951 1.00 73.20  ? 792  ARG A C   1 
ATOM   3932 O  O   . ARG A 1 529 ? -27.901 -40.418 -11.825 1.00 73.08  ? 792  ARG A O   1 
ATOM   3933 C  CB  . ARG A 1 529 ? -27.930 -42.595 -9.662  1.00 64.28  ? 792  ARG A CB  1 
ATOM   3934 C  CG  . ARG A 1 529 ? -29.046 -43.215 -8.834  1.00 61.27  ? 792  ARG A CG  1 
ATOM   3935 C  CD  . ARG A 1 529 ? -28.955 -42.893 -7.350  1.00 61.25  ? 792  ARG A CD  1 
ATOM   3936 N  NE  . ARG A 1 529 ? -29.665 -43.889 -6.554  1.00 58.59  ? 792  ARG A NE  1 
ATOM   3937 C  CZ  . ARG A 1 529 ? -29.650 -43.958 -5.230  1.00 52.22  ? 792  ARG A CZ  1 
ATOM   3938 N  NH1 . ARG A 1 529 ? -28.981 -43.053 -4.530  1.00 49.73  ? 792  ARG A NH1 1 
ATOM   3939 N  NH2 . ARG A 1 529 ? -30.326 -44.921 -4.616  1.00 47.27  ? 792  ARG A NH2 1 
ATOM   3940 N  N   . THR A 1 530 ? -26.397 -41.878 -12.713 1.00 86.12  ? 793  THR A N   1 
ATOM   3941 C  CA  . THR A 1 530 ? -25.741 -40.937 -13.673 1.00 106.56 ? 793  THR A CA  1 
ATOM   3942 C  C   . THR A 1 530 ? -25.524 -41.641 -15.021 1.00 113.42 ? 793  THR A C   1 
ATOM   3943 O  O   . THR A 1 530 ? -24.796 -42.653 -15.043 1.00 109.35 ? 793  THR A O   1 
ATOM   3944 C  CB  . THR A 1 530 ? -24.420 -40.375 -13.128 1.00 109.15 ? 793  THR A CB  1 
ATOM   3945 O  OG1 . THR A 1 530 ? -23.665 -41.462 -12.592 1.00 112.87 ? 793  THR A OG1 1 
ATOM   3946 C  CG2 . THR A 1 530 ? -24.618 -39.310 -12.071 1.00 106.97 ? 793  THR A CG2 1 
ATOM   3947 N  N   . THR A 1 531 ? -26.116 -41.102 -16.096 1.00 124.40 ? 794  THR A N   1 
ATOM   3948 C  CA  . THR A 1 531 ? -26.128 -41.687 -17.467 1.00 127.82 ? 794  THR A CA  1 
ATOM   3949 C  C   . THR A 1 531 ? -24.976 -41.088 -18.285 1.00 120.28 ? 794  THR A C   1 
ATOM   3950 O  O   . THR A 1 531 ? -24.088 -41.869 -18.671 1.00 114.81 ? 794  THR A O   1 
ATOM   3951 C  CB  . THR A 1 531 ? -27.479 -41.468 -18.167 1.00 130.91 ? 794  THR A CB  1 
ATOM   3952 O  OG1 . THR A 1 531 ? -27.489 -40.166 -18.754 1.00 141.04 ? 794  THR A OG1 1 
ATOM   3953 C  CG2 . THR A 1 531 ? -28.669 -41.617 -17.242 1.00 128.52 ? 794  THR A CG2 1 
ATOM   3954 N  N   . ALA A 1 536 ? -21.079 -40.541 -24.617 1.00 99.79  ? 799  ALA A N   1 
ATOM   3955 C  CA  . ALA A 1 536 ? -21.132 -41.805 -25.393 1.00 94.76  ? 799  ALA A CA  1 
ATOM   3956 C  C   . ALA A 1 536 ? -22.563 -42.365 -25.421 1.00 89.19  ? 799  ALA A C   1 
ATOM   3957 O  O   . ALA A 1 536 ? -23.450 -41.850 -24.699 1.00 94.15  ? 799  ALA A O   1 
ATOM   3958 C  CB  . ALA A 1 536 ? -20.163 -42.809 -24.811 1.00 90.92  ? 799  ALA A CB  1 
ATOM   3959 N  N   . THR A 1 537 ? -22.768 -43.415 -26.212 1.00 77.83  ? 800  THR A N   1 
ATOM   3960 C  CA  . THR A 1 537 ? -24.090 -44.040 -26.466 1.00 62.93  ? 800  THR A CA  1 
ATOM   3961 C  C   . THR A 1 537 ? -24.175 -45.322 -25.627 1.00 55.48  ? 800  THR A C   1 
ATOM   3962 O  O   . THR A 1 537 ? -23.273 -46.205 -25.758 1.00 63.25  ? 800  THR A O   1 
ATOM   3963 C  CB  . THR A 1 537 ? -24.256 -44.255 -27.971 1.00 74.09  ? 800  THR A CB  1 
ATOM   3964 O  OG1 . THR A 1 537 ? -23.594 -45.473 -28.307 1.00 73.31  ? 800  THR A OG1 1 
ATOM   3965 C  CG2 . THR A 1 537 ? -23.681 -43.116 -28.787 1.00 72.54  ? 800  THR A CG2 1 
ATOM   3966 N  N   A HIS A 1 538 ? -25.212 -45.436 -24.789 0.25 47.96  ? 801  HIS A N   1 
ATOM   3967 N  N   B HIS A 1 538 ? -25.229 -45.429 -24.807 0.25 49.44  ? 801  HIS A N   1 
ATOM   3968 C  CA  A HIS A 1 538 ? -25.378 -46.536 -23.801 0.25 40.95  ? 801  HIS A CA  1 
ATOM   3969 C  CA  B HIS A 1 538 ? -25.438 -46.507 -23.801 0.25 43.04  ? 801  HIS A CA  1 
ATOM   3970 C  C   A HIS A 1 538 ? -26.406 -47.551 -24.326 0.25 35.83  ? 801  HIS A C   1 
ATOM   3971 C  C   B HIS A 1 538 ? -26.430 -47.547 -24.341 0.25 36.86  ? 801  HIS A C   1 
ATOM   3972 O  O   A HIS A 1 538 ? -27.513 -47.654 -23.757 0.25 33.50  ? 801  HIS A O   1 
ATOM   3973 O  O   B HIS A 1 538 ? -27.546 -47.663 -23.791 0.25 34.26  ? 801  HIS A O   1 
ATOM   3974 C  CB  A HIS A 1 538 ? -25.690 -45.943 -22.423 0.25 41.63  ? 801  HIS A CB  1 
ATOM   3975 C  CB  B HIS A 1 538 ? -25.884 -45.886 -22.475 0.25 45.75  ? 801  HIS A CB  1 
ATOM   3976 C  CG  A HIS A 1 538 ? -24.550 -45.184 -21.830 0.25 40.76  ? 801  HIS A CG  1 
ATOM   3977 C  CG  B HIS A 1 538 ? -26.665 -44.627 -22.645 0.25 46.30  ? 801  HIS A CG  1 
ATOM   3978 N  ND1 A HIS A 1 538 ? -24.388 -45.040 -20.465 0.25 42.02  ? 801  HIS A ND1 1 
ATOM   3979 N  ND1 B HIS A 1 538 ? -26.463 -43.518 -21.844 0.25 47.85  ? 801  HIS A ND1 1 
ATOM   3980 C  CD2 A HIS A 1 538 ? -23.504 -44.547 -22.402 0.25 40.82  ? 801  HIS A CD2 1 
ATOM   3981 C  CD2 B HIS A 1 538 ? -27.618 -44.285 -23.538 0.25 46.92  ? 801  HIS A CD2 1 
ATOM   3982 C  CE1 A HIS A 1 538 ? -23.302 -44.333 -20.223 0.25 40.60  ? 801  HIS A CE1 1 
ATOM   3983 C  CE1 B HIS A 1 538 ? -27.278 -42.554 -22.222 0.25 48.78  ? 801  HIS A CE1 1 
ATOM   3984 N  NE2 A HIS A 1 538 ? -22.742 -44.019 -21.395 0.25 41.37  ? 801  HIS A NE2 1 
ATOM   3985 N  NE2 B HIS A 1 538 ? -27.999 -43.000 -23.262 0.25 47.19  ? 801  HIS A NE2 1 
ATOM   3986 N  N   . GLU A 1 539 ? -26.018 -48.314 -25.351 1.00 32.96  ? 802  GLU A N   1 
ATOM   3987 C  CA  . GLU A 1 539 ? -26.900 -49.313 -26.005 1.00 32.33  ? 802  GLU A CA  1 
ATOM   3988 C  C   . GLU A 1 539 ? -27.250 -50.468 -25.071 1.00 32.85  ? 802  GLU A C   1 
ATOM   3989 O  O   . GLU A 1 539 ? -28.245 -51.173 -25.401 1.00 29.55  ? 802  GLU A O   1 
ATOM   3990 C  CB  . GLU A 1 539 ? -26.298 -49.863 -27.283 1.00 40.68  ? 802  GLU A CB  1 
ATOM   3991 C  CG  . GLU A 1 539 ? -26.516 -48.939 -28.460 1.00 45.81  ? 802  GLU A CG  1 
ATOM   3992 C  CD  . GLU A 1 539 ? -25.325 -48.031 -28.621 1.00 52.57  ? 802  GLU A CD  1 
ATOM   3993 O  OE1 . GLU A 1 539 ? -25.190 -47.468 -29.739 1.00 63.05  ? 802  GLU A OE1 1 
ATOM   3994 O  OE2 . GLU A 1 539 ? -24.510 -47.932 -27.637 1.00 55.78  ? 802  GLU A OE2 1 
ATOM   3995 N  N   . TRP A 1 540 ? -26.475 -50.676 -23.975 1.00 24.55  ? 803  TRP A N   1 
ATOM   3996 C  CA  . TRP A 1 540 ? -26.748 -51.769 -23.010 1.00 25.35  ? 803  TRP A CA  1 
ATOM   3997 C  C   . TRP A 1 540 ? -27.886 -51.394 -22.060 1.00 26.68  ? 803  TRP A C   1 
ATOM   3998 O  O   . TRP A 1 540 ? -28.291 -52.206 -21.250 1.00 25.22  ? 803  TRP A O   1 
ATOM   3999 C  CB  . TRP A 1 540 ? -25.445 -52.089 -22.241 1.00 24.43  ? 803  TRP A CB  1 
ATOM   4000 C  CG  . TRP A 1 540 ? -24.865 -50.928 -21.505 1.00 21.33  ? 803  TRP A CG  1 
ATOM   4001 C  CD1 . TRP A 1 540 ? -25.164 -50.504 -20.247 1.00 22.20  ? 803  TRP A CD1 1 
ATOM   4002 C  CD2 . TRP A 1 540 ? -23.837 -50.041 -21.994 1.00 22.78  ? 803  TRP A CD2 1 
ATOM   4003 N  NE1 . TRP A 1 540 ? -24.427 -49.402 -19.932 1.00 25.19  ? 803  TRP A NE1 1 
ATOM   4004 C  CE2 . TRP A 1 540 ? -23.570 -49.119 -20.959 1.00 24.95  ? 803  TRP A CE2 1 
ATOM   4005 C  CE3 . TRP A 1 540 ? -23.091 -49.973 -23.174 1.00 25.11  ? 803  TRP A CE3 1 
ATOM   4006 C  CZ2 . TRP A 1 540 ? -22.618 -48.113 -21.096 1.00 29.49  ? 803  TRP A CZ2 1 
ATOM   4007 C  CZ3 . TRP A 1 540 ? -22.133 -48.993 -23.301 1.00 29.75  ? 803  TRP A CZ3 1 
ATOM   4008 C  CH2 . TRP A 1 540 ? -21.886 -48.088 -22.265 1.00 27.58  ? 803  TRP A CH2 1 
ATOM   4009 N  N   . MET A 1 541 ? -28.374 -50.153 -22.097 1.00 26.78  ? 804  MET A N   1 
ATOM   4010 C  CA  . MET A 1 541 ? -29.425 -49.727 -21.166 1.00 26.98  ? 804  MET A CA  1 
ATOM   4011 C  C   . MET A 1 541 ? -30.780 -50.057 -21.826 1.00 31.94  ? 804  MET A C   1 
ATOM   4012 O  O   . MET A 1 541 ? -31.394 -49.164 -22.428 1.00 30.63  ? 804  MET A O   1 
ATOM   4013 C  CB  . MET A 1 541 ? -29.294 -48.247 -20.817 1.00 29.33  ? 804  MET A CB  1 
ATOM   4014 C  CG  . MET A 1 541 ? -27.982 -47.916 -20.073 1.00 31.32  ? 804  MET A CG  1 
ATOM   4015 S  SD  . MET A 1 541 ? -27.854 -48.801 -18.487 1.00 32.17  ? 804  MET A SD  1 
ATOM   4016 C  CE  . MET A 1 541 ? -29.035 -47.909 -17.492 1.00 33.40  ? 804  MET A CE  1 
ATOM   4017 N  N   . THR A 1 542 ? -31.229 -51.302 -21.691 1.00 30.35  ? 805  THR A N   1 
ATOM   4018 C  CA  . THR A 1 542 ? -32.381 -51.858 -22.457 1.00 30.17  ? 805  THR A CA  1 
ATOM   4019 C  C   . THR A 1 542 ? -32.789 -53.191 -21.848 1.00 29.17  ? 805  THR A C   1 
ATOM   4020 O  O   . THR A 1 542 ? -31.926 -53.801 -21.201 1.00 24.64  ? 805  THR A O   1 
ATOM   4021 C  CB  . THR A 1 542 ? -32.016 -52.053 -23.932 1.00 34.10  ? 805  THR A CB  1 
ATOM   4022 O  OG1 . THR A 1 542 ? -33.145 -52.591 -24.631 1.00 33.96  ? 805  THR A OG1 1 
ATOM   4023 C  CG2 . THR A 1 542 ? -30.843 -52.989 -24.102 1.00 38.04  ? 805  THR A CG2 1 
ATOM   4024 N  N   . THR A 1 543 ? -34.044 -53.649 -22.041 1.00 26.56  ? 806  THR A N   1 
ATOM   4025 C  CA  . THR A 1 543 ? -34.469 -55.029 -21.693 1.00 28.53  ? 806  THR A CA  1 
ATOM   4026 C  C   . THR A 1 543 ? -34.528 -55.932 -22.932 1.00 28.89  ? 806  THR A C   1 
ATOM   4027 O  O   . THR A 1 543 ? -34.888 -57.087 -22.804 1.00 29.65  ? 806  THR A O   1 
ATOM   4028 C  CB  . THR A 1 543 ? -35.807 -54.981 -20.938 1.00 36.75  ? 806  THR A CB  1 
ATOM   4029 O  OG1 . THR A 1 543 ? -36.684 -54.242 -21.792 1.00 33.68  ? 806  THR A OG1 1 
ATOM   4030 C  CG2 . THR A 1 543 ? -35.664 -54.275 -19.601 1.00 35.38  ? 806  THR A CG2 1 
ATOM   4031 N  N   . GLU A 1 544 ? -34.083 -55.451 -24.096 0.50 29.08  ? 807  GLU A N   1 
ATOM   4032 C  CA  . GLU A 1 544 ? -33.969 -56.281 -25.327 0.50 29.13  ? 807  GLU A CA  1 
ATOM   4033 C  C   . GLU A 1 544 ? -32.928 -57.394 -25.106 0.50 29.40  ? 807  GLU A C   1 
ATOM   4034 O  O   . GLU A 1 544 ? -31.998 -57.192 -24.303 0.50 27.15  ? 807  GLU A O   1 
ATOM   4035 C  CB  . GLU A 1 544 ? -33.625 -55.391 -26.518 0.50 30.94  ? 807  GLU A CB  1 
ATOM   4036 C  CG  . GLU A 1 544 ? -33.688 -56.113 -27.846 0.50 34.77  ? 807  GLU A CG  1 
ATOM   4037 C  CD  . GLU A 1 544 ? -34.134 -55.242 -29.008 0.50 37.21  ? 807  GLU A CD  1 
ATOM   4038 O  OE1 . GLU A 1 544 ? -34.868 -55.759 -29.874 0.50 37.46  ? 807  GLU A OE1 1 
ATOM   4039 O  OE2 . GLU A 1 544 ? -33.758 -54.045 -29.033 0.50 37.36  ? 807  GLU A OE2 1 
ATOM   4040 N  N   . ASP A 1 545 ? -33.123 -58.550 -25.746 0.50 28.07  ? 808  ASP A N   1 
ATOM   4041 C  CA  . ASP A 1 545 ? -32.121 -59.643 -25.848 0.50 30.07  ? 808  ASP A CA  1 
ATOM   4042 C  C   . ASP A 1 545 ? -30.763 -58.998 -26.165 0.50 26.89  ? 808  ASP A C   1 
ATOM   4043 O  O   . ASP A 1 545 ? -30.726 -58.142 -27.069 0.50 25.28  ? 808  ASP A O   1 
ATOM   4044 C  CB  . ASP A 1 545 ? -32.539 -60.636 -26.937 0.50 32.98  ? 808  ASP A CB  1 
ATOM   4045 C  CG  . ASP A 1 545 ? -31.699 -61.899 -27.031 0.50 36.65  ? 808  ASP A CG  1 
ATOM   4046 O  OD1 . ASP A 1 545 ? -30.459 -61.808 -26.867 0.50 37.22  ? 808  ASP A OD1 1 
ATOM   4047 O  OD2 . ASP A 1 545 ? -32.293 -62.973 -27.286 0.50 38.49  ? 808  ASP A OD2 1 
ATOM   4048 N  N   . MET A 1 546 ? -29.692 -59.352 -25.449 0.50 25.68  ? 809  MET A N   1 
ATOM   4049 C  CA  . MET A 1 546 ? -28.368 -58.710 -25.692 0.50 24.83  ? 809  MET A CA  1 
ATOM   4050 C  C   . MET A 1 546 ? -27.733 -59.295 -26.965 0.50 24.46  ? 809  MET A C   1 
ATOM   4051 O  O   . MET A 1 546 ? -26.896 -58.592 -27.563 0.50 23.83  ? 809  MET A O   1 
ATOM   4052 C  CB  . MET A 1 546 ? -27.425 -58.841 -24.489 0.50 25.13  ? 809  MET A CB  1 
ATOM   4053 C  CG  . MET A 1 546 ? -27.756 -57.891 -23.320 0.50 24.60  ? 809  MET A CG  1 
ATOM   4054 S  SD  . MET A 1 546 ? -27.997 -56.120 -23.745 0.50 27.27  ? 809  MET A SD  1 
ATOM   4055 C  CE  . MET A 1 546 ? -26.524 -55.772 -24.700 0.50 27.74  ? 809  MET A CE  1 
ATOM   4056 N  N   . LEU A 1 547 ? -28.134 -60.493 -27.415 1.00 23.03  ? 810  LEU A N   1 
ATOM   4057 C  CA  . LEU A 1 547 ? -27.633 -61.019 -28.720 1.00 25.02  ? 810  LEU A CA  1 
ATOM   4058 C  C   . LEU A 1 547 ? -28.180 -60.131 -29.852 1.00 24.67  ? 810  LEU A C   1 
ATOM   4059 O  O   . LEU A 1 547 ? -27.420 -59.826 -30.773 1.00 23.13  ? 810  LEU A O   1 
ATOM   4060 C  CB  . LEU A 1 547 ? -27.902 -62.499 -28.986 1.00 27.86  ? 810  LEU A CB  1 
ATOM   4061 C  CG  . LEU A 1 547 ? -27.205 -63.059 -30.238 1.00 26.40  ? 810  LEU A CG  1 
ATOM   4062 C  CD1 . LEU A 1 547 ? -25.664 -63.013 -30.130 1.00 27.46  ? 810  LEU A CD1 1 
ATOM   4063 C  CD2 . LEU A 1 547 ? -27.616 -64.483 -30.510 1.00 31.11  ? 810  LEU A CD2 1 
ATOM   4064 N  N   . THR A 1 548 ? -29.459 -59.753 -29.798 1.00 23.44  ? 811  THR A N   1 
ATOM   4065 C  CA  . THR A 1 548 ? -30.092 -58.852 -30.787 1.00 25.16  ? 811  THR A CA  1 
ATOM   4066 C  C   . THR A 1 548 ? -29.380 -57.490 -30.788 1.00 24.84  ? 811  THR A C   1 
ATOM   4067 O  O   . THR A 1 548 ? -29.100 -56.938 -31.869 1.00 23.85  ? 811  THR A O   1 
ATOM   4068 C  CB  . THR A 1 548 ? -31.598 -58.719 -30.505 1.00 29.31  ? 811  THR A CB  1 
ATOM   4069 O  OG1 . THR A 1 548 ? -32.146 -60.046 -30.536 1.00 28.95  ? 811  THR A OG1 1 
ATOM   4070 C  CG2 . THR A 1 548 ? -32.262 -57.836 -31.529 1.00 29.35  ? 811  THR A CG2 1 
ATOM   4071 N  N   . VAL A 1 549 ? -29.085 -56.954 -29.611 1.00 23.63  ? 812  VAL A N   1 
ATOM   4072 C  CA  . VAL A 1 549 ? -28.382 -55.657 -29.472 1.00 24.42  ? 812  VAL A CA  1 
ATOM   4073 C  C   . VAL A 1 549 ? -26.957 -55.800 -30.019 1.00 22.06  ? 812  VAL A C   1 
ATOM   4074 O  O   . VAL A 1 549 ? -26.488 -54.864 -30.753 1.00 21.81  ? 812  VAL A O   1 
ATOM   4075 C  CB  . VAL A 1 549 ? -28.411 -55.123 -28.031 1.00 25.78  ? 812  VAL A CB  1 
ATOM   4076 C  CG1 . VAL A 1 549 ? -27.656 -53.801 -27.967 1.00 25.99  ? 812  VAL A CG1 1 
ATOM   4077 C  CG2 . VAL A 1 549 ? -29.833 -54.930 -27.525 1.00 28.15  ? 812  VAL A CG2 1 
ATOM   4078 N  N   . TRP A 1 550 ? -26.285 -56.912 -29.727 1.00 23.41  ? 813  TRP A N   1 
ATOM   4079 C  CA  . TRP A 1 550 ? -24.893 -57.134 -30.194 1.00 21.75  ? 813  TRP A CA  1 
ATOM   4080 C  C   . TRP A 1 550 ? -24.913 -57.080 -31.727 1.00 25.14  ? 813  TRP A C   1 
ATOM   4081 O  O   . TRP A 1 550 ? -24.087 -56.391 -32.357 1.00 22.78  ? 813  TRP A O   1 
ATOM   4082 C  CB  . TRP A 1 550 ? -24.326 -58.440 -29.642 1.00 21.67  ? 813  TRP A CB  1 
ATOM   4083 C  CG  . TRP A 1 550 ? -22.875 -58.614 -29.936 1.00 21.68  ? 813  TRP A CG  1 
ATOM   4084 C  CD1 . TRP A 1 550 ? -21.847 -58.368 -29.054 1.00 21.93  ? 813  TRP A CD1 1 
ATOM   4085 C  CD2 . TRP A 1 550 ? -22.252 -59.018 -31.168 1.00 21.44  ? 813  TRP A CD2 1 
ATOM   4086 N  NE1 . TRP A 1 550 ? -20.637 -58.628 -29.633 1.00 21.12  ? 813  TRP A NE1 1 
ATOM   4087 C  CE2 . TRP A 1 550 ? -20.845 -58.987 -30.944 1.00 22.45  ? 813  TRP A CE2 1 
ATOM   4088 C  CE3 . TRP A 1 550 ? -22.720 -59.449 -32.415 1.00 22.70  ? 813  TRP A CE3 1 
ATOM   4089 C  CZ2 . TRP A 1 550 ? -19.919 -59.354 -31.919 1.00 22.58  ? 813  TRP A CZ2 1 
ATOM   4090 C  CZ3 . TRP A 1 550 ? -21.799 -59.781 -33.389 1.00 21.99  ? 813  TRP A CZ3 1 
ATOM   4091 C  CH2 . TRP A 1 550 ? -20.420 -59.729 -33.144 1.00 22.17  ? 813  TRP A CH2 1 
ATOM   4092 N  N   . ASN A 1 551 ? -25.841 -57.813 -32.347 1.00 23.23  ? 814  ASN A N   1 
ATOM   4093 C  CA  . ASN A 1 551 ? -25.956 -57.838 -33.822 1.00 24.62  ? 814  ASN A CA  1 
ATOM   4094 C  C   . ASN A 1 551 ? -26.195 -56.425 -34.362 1.00 22.43  ? 814  ASN A C   1 
ATOM   4095 O  O   . ASN A 1 551 ? -25.588 -56.125 -35.404 1.00 25.52  ? 814  ASN A O   1 
ATOM   4096 C  CB  . ASN A 1 551 ? -27.075 -58.767 -34.315 1.00 25.67  ? 814  ASN A CB  1 
ATOM   4097 C  CG  . ASN A 1 551 ? -26.550 -60.151 -34.554 1.00 30.17  ? 814  ASN A CG  1 
ATOM   4098 O  OD1 . ASN A 1 551 ? -25.678 -60.355 -35.404 1.00 35.48  ? 814  ASN A OD1 1 
ATOM   4099 N  ND2 . ASN A 1 551 ? -27.072 -61.126 -33.833 1.00 36.18  ? 814  ASN A ND2 1 
ATOM   4100 N  N   . ARG A 1 552 ? -27.068 -55.636 -33.753 1.00 24.69  ? 815  ARG A N   1 
ATOM   4101 C  CA  . ARG A 1 552 ? -27.390 -54.293 -34.246 1.00 25.63  ? 815  ARG A CA  1 
ATOM   4102 C  C   . ARG A 1 552 ? -26.113 -53.441 -34.200 1.00 27.39  ? 815  ARG A C   1 
ATOM   4103 O  O   . ARG A 1 552 ? -25.792 -52.773 -35.191 1.00 28.72  ? 815  ARG A O   1 
ATOM   4104 C  CB  . ARG A 1 552 ? -28.531 -53.678 -33.456 1.00 28.84  ? 815  ARG A CB  1 
ATOM   4105 C  CG  . ARG A 1 552 ? -28.968 -52.319 -33.979 1.00 31.42  ? 815  ARG A CG  1 
ATOM   4106 C  CD  . ARG A 1 552 ? -30.043 -51.668 -33.124 1.00 36.85  ? 815  ARG A CD  1 
ATOM   4107 N  NE  . ARG A 1 552 ? -31.169 -52.582 -33.141 1.00 45.89  ? 815  ARG A NE  1 
ATOM   4108 C  CZ  . ARG A 1 552 ? -31.755 -53.135 -32.066 1.00 47.15  ? 815  ARG A CZ  1 
ATOM   4109 N  NH1 . ARG A 1 552 ? -31.371 -52.832 -30.838 1.00 43.31  ? 815  ARG A NH1 1 
ATOM   4110 N  NH2 . ARG A 1 552 ? -32.775 -53.947 -32.262 1.00 51.66  ? 815  ARG A NH2 1 
ATOM   4111 N  N   . VAL A 1 553 ? -25.388 -53.481 -33.085 1.00 25.33  ? 816  VAL A N   1 
ATOM   4112 C  CA  . VAL A 1 553 ? -24.250 -52.552 -32.839 1.00 24.82  ? 816  VAL A CA  1 
ATOM   4113 C  C   . VAL A 1 553 ? -23.034 -52.980 -33.676 1.00 23.07  ? 816  VAL A C   1 
ATOM   4114 O  O   . VAL A 1 553 ? -22.357 -52.111 -34.292 1.00 27.30  ? 816  VAL A O   1 
ATOM   4115 C  CB  . VAL A 1 553 ? -23.968 -52.524 -31.316 1.00 26.30  ? 816  VAL A CB  1 
ATOM   4116 C  CG1 . VAL A 1 553 ? -22.600 -51.953 -31.024 1.00 29.64  ? 816  VAL A CG1 1 
ATOM   4117 C  CG2 . VAL A 1 553 ? -25.072 -51.778 -30.587 1.00 27.07  ? 816  VAL A CG2 1 
ATOM   4118 N  N   . TRP A 1 554 ? -22.666 -54.255 -33.662 1.00 22.43  ? 817  TRP A N   1 
ATOM   4119 C  CA  . TRP A 1 554 ? -21.405 -54.744 -34.237 1.00 20.60  ? 817  TRP A CA  1 
ATOM   4120 C  C   . TRP A 1 554 ? -21.529 -55.158 -35.697 1.00 23.27  ? 817  TRP A C   1 
ATOM   4121 O  O   . TRP A 1 554 ? -20.491 -55.238 -36.331 1.00 22.83  ? 817  TRP A O   1 
ATOM   4122 C  CB  . TRP A 1 554 ? -20.835 -55.883 -33.398 1.00 23.52  ? 817  TRP A CB  1 
ATOM   4123 C  CG  . TRP A 1 554 ? -20.318 -55.413 -32.059 1.00 22.16  ? 817  TRP A CG  1 
ATOM   4124 C  CD1 . TRP A 1 554 ? -20.905 -55.559 -30.839 1.00 23.47  ? 817  TRP A CD1 1 
ATOM   4125 C  CD2 . TRP A 1 554 ? -19.087 -54.689 -31.829 1.00 21.28  ? 817  TRP A CD2 1 
ATOM   4126 N  NE1 . TRP A 1 554 ? -20.139 -54.966 -29.858 1.00 20.92  ? 817  TRP A NE1 1 
ATOM   4127 C  CE2 . TRP A 1 554 ? -18.995 -54.465 -30.438 1.00 19.71  ? 817  TRP A CE2 1 
ATOM   4128 C  CE3 . TRP A 1 554 ? -18.043 -54.261 -32.664 1.00 20.74  ? 817  TRP A CE3 1 
ATOM   4129 C  CZ2 . TRP A 1 554 ? -17.919 -53.786 -29.871 1.00 20.10  ? 817  TRP A CZ2 1 
ATOM   4130 C  CZ3 . TRP A 1 554 ? -16.961 -53.606 -32.092 1.00 21.59  ? 817  TRP A CZ3 1 
ATOM   4131 C  CH2 . TRP A 1 554 ? -16.912 -53.376 -30.721 1.00 19.72  ? 817  TRP A CH2 1 
ATOM   4132 N  N   . ILE A 1 555 ? -22.750 -55.424 -36.194 1.00 24.79  ? 818  ILE A N   1 
ATOM   4133 C  CA  . ILE A 1 555 ? -22.939 -55.922 -37.585 1.00 25.85  ? 818  ILE A CA  1 
ATOM   4134 C  C   . ILE A 1 555 ? -23.789 -54.914 -38.346 1.00 25.90  ? 818  ILE A C   1 
ATOM   4135 O  O   . ILE A 1 555 ? -23.204 -54.240 -39.220 1.00 27.07  ? 818  ILE A O   1 
ATOM   4136 C  CB  . ILE A 1 555 ? -23.552 -57.329 -37.662 1.00 27.28  ? 818  ILE A CB  1 
ATOM   4137 C  CG1 . ILE A 1 555 ? -22.788 -58.363 -36.837 1.00 26.52  ? 818  ILE A CG1 1 
ATOM   4138 C  CG2 . ILE A 1 555 ? -23.636 -57.768 -39.136 1.00 28.29  ? 818  ILE A CG2 1 
ATOM   4139 C  CD1 . ILE A 1 555 ? -21.382 -58.478 -37.183 1.00 28.69  ? 818  ILE A CD1 1 
ATOM   4140 N  N   . GLN A 1 556 ? -25.078 -54.780 -38.003 1.00 28.78  ? 819  GLN A N   1 
ATOM   4141 C  CA  . GLN A 1 556 ? -26.070 -54.064 -38.862 1.00 31.39  ? 819  GLN A CA  1 
ATOM   4142 C  C   . GLN A 1 556 ? -25.641 -52.604 -39.019 1.00 31.78  ? 819  GLN A C   1 
ATOM   4143 O  O   . GLN A 1 556 ? -25.556 -52.132 -40.162 1.00 30.90  ? 819  GLN A O   1 
ATOM   4144 C  CB  . GLN A 1 556 ? -27.468 -54.187 -38.242 1.00 34.11  ? 819  GLN A CB  1 
ATOM   4145 C  CG  . GLN A 1 556 ? -28.592 -53.560 -39.061 1.00 42.33  ? 819  GLN A CG  1 
ATOM   4146 C  CD  . GLN A 1 556 ? -29.840 -53.311 -38.238 1.00 50.46  ? 819  GLN A CD  1 
ATOM   4147 O  OE1 . GLN A 1 556 ? -30.433 -52.228 -38.275 1.00 59.27  ? 819  GLN A OE1 1 
ATOM   4148 N  NE2 . GLN A 1 556 ? -30.226 -54.293 -37.440 1.00 49.14  ? 819  GLN A NE2 1 
ATOM   4149 N  N   . GLU A 1 557 ? -25.362 -51.907 -37.915 1.00 26.35  ? 820  GLU A N   1 
ATOM   4150 C  CA  . GLU A 1 557 ? -25.135 -50.447 -37.893 1.00 28.60  ? 820  GLU A CA  1 
ATOM   4151 C  C   . GLU A 1 557 ? -23.637 -50.108 -37.962 1.00 28.77  ? 820  GLU A C   1 
ATOM   4152 O  O   . GLU A 1 557 ? -23.286 -48.915 -37.855 1.00 32.83  ? 820  GLU A O   1 
ATOM   4153 C  CB  . GLU A 1 557 ? -25.802 -49.845 -36.669 1.00 30.74  ? 820  GLU A CB  1 
ATOM   4154 C  CG  . GLU A 1 557 ? -27.300 -50.140 -36.650 1.00 38.74  ? 820  GLU A CG  1 
ATOM   4155 C  CD  . GLU A 1 557 ? -28.155 -49.396 -35.626 1.00 50.11  ? 820  GLU A CD  1 
ATOM   4156 O  OE1 . GLU A 1 557 ? -27.620 -48.955 -34.566 1.00 50.44  ? 820  GLU A OE1 1 
ATOM   4157 O  OE2 . GLU A 1 557 ? -29.392 -49.281 -35.878 1.00 63.45  ? 820  GLU A OE2 1 
ATOM   4158 N  N   . ASN A 1 558 ? -22.783 -51.107 -38.076 1.00 26.71  ? 821  ASN A N   1 
ATOM   4159 C  CA  . ASN A 1 558 ? -21.314 -50.900 -38.054 1.00 26.60  ? 821  ASN A CA  1 
ATOM   4160 C  C   . ASN A 1 558 ? -20.831 -50.546 -39.461 1.00 27.29  ? 821  ASN A C   1 
ATOM   4161 O  O   . ASN A 1 558 ? -20.783 -51.413 -40.326 1.00 28.54  ? 821  ASN A O   1 
ATOM   4162 C  CB  . ASN A 1 558 ? -20.657 -52.173 -37.556 1.00 26.08  ? 821  ASN A CB  1 
ATOM   4163 C  CG  . ASN A 1 558 ? -19.152 -52.112 -37.470 1.00 26.08  ? 821  ASN A CG  1 
ATOM   4164 O  OD1 . ASN A 1 558 ? -18.542 -51.144 -37.918 1.00 27.35  ? 821  ASN A OD1 1 
ATOM   4165 N  ND2 . ASN A 1 558 ? -18.567 -53.192 -36.966 1.00 22.90  ? 821  ASN A ND2 1 
ATOM   4166 N  N   . PRO A 1 559 ? -20.437 -49.288 -39.738 1.00 27.53  ? 822  PRO A N   1 
ATOM   4167 C  CA  . PRO A 1 559 ? -20.065 -48.893 -41.101 1.00 30.65  ? 822  PRO A CA  1 
ATOM   4168 C  C   . PRO A 1 559 ? -18.754 -49.508 -41.583 1.00 29.71  ? 822  PRO A C   1 
ATOM   4169 O  O   . PRO A 1 559 ? -18.482 -49.482 -42.767 1.00 30.90  ? 822  PRO A O   1 
ATOM   4170 C  CB  . PRO A 1 559 ? -19.986 -47.363 -41.040 1.00 32.54  ? 822  PRO A CB  1 
ATOM   4171 C  CG  . PRO A 1 559 ? -19.711 -47.060 -39.585 1.00 34.45  ? 822  PRO A CG  1 
ATOM   4172 C  CD  . PRO A 1 559 ? -20.377 -48.174 -38.787 1.00 31.82  ? 822  PRO A CD  1 
ATOM   4173 N  N   . TRP A 1 560 ? -17.975 -50.129 -40.696 1.00 26.89  ? 823  TRP A N   1 
ATOM   4174 C  CA  . TRP A 1 560 ? -16.736 -50.829 -41.100 1.00 29.33  ? 823  TRP A CA  1 
ATOM   4175 C  C   . TRP A 1 560 ? -16.963 -52.317 -41.419 1.00 31.60  ? 823  TRP A C   1 
ATOM   4176 O  O   . TRP A 1 560 ? -15.975 -52.942 -41.767 1.00 37.20  ? 823  TRP A O   1 
ATOM   4177 C  CB  . TRP A 1 560 ? -15.669 -50.647 -40.009 1.00 28.02  ? 823  TRP A CB  1 
ATOM   4178 C  CG  . TRP A 1 560 ? -15.227 -49.222 -39.857 1.00 27.06  ? 823  TRP A CG  1 
ATOM   4179 C  CD1 . TRP A 1 560 ? -14.277 -48.575 -40.598 1.00 28.00  ? 823  TRP A CD1 1 
ATOM   4180 C  CD2 . TRP A 1 560 ? -15.730 -48.257 -38.922 1.00 26.38  ? 823  TRP A CD2 1 
ATOM   4181 N  NE1 . TRP A 1 560 ? -14.159 -47.282 -40.175 1.00 27.41  ? 823  TRP A NE1 1 
ATOM   4182 C  CE2 . TRP A 1 560 ? -15.035 -47.052 -39.151 1.00 25.95  ? 823  TRP A CE2 1 
ATOM   4183 C  CE3 . TRP A 1 560 ? -16.661 -48.306 -37.889 1.00 25.79  ? 823  TRP A CE3 1 
ATOM   4184 C  CZ2 . TRP A 1 560 ? -15.243 -45.919 -38.372 1.00 27.36  ? 823  TRP A CZ2 1 
ATOM   4185 C  CZ3 . TRP A 1 560 ? -16.910 -47.176 -37.156 1.00 26.27  ? 823  TRP A CZ3 1 
ATOM   4186 C  CH2 . TRP A 1 560 ? -16.205 -45.986 -37.393 1.00 27.62  ? 823  TRP A CH2 1 
ATOM   4187 N  N   . MET A 1 561 ? -18.184 -52.851 -41.289 1.00 30.81  ? 824  MET A N   1 
ATOM   4188 C  CA  . MET A 1 561 ? -18.527 -54.286 -41.527 1.00 30.75  ? 824  MET A CA  1 
ATOM   4189 C  C   . MET A 1 561 ? -19.337 -54.359 -42.838 1.00 28.16  ? 824  MET A C   1 
ATOM   4190 O  O   . MET A 1 561 ? -20.477 -53.885 -42.849 1.00 30.20  ? 824  MET A O   1 
ATOM   4191 C  CB  . MET A 1 561 ? -19.344 -54.803 -40.333 1.00 30.79  ? 824  MET A CB  1 
ATOM   4192 C  CG  . MET A 1 561 ? -19.567 -56.333 -40.257 1.00 37.05  ? 824  MET A CG  1 
ATOM   4193 S  SD  . MET A 1 561 ? -18.011 -57.153 -40.059 1.00 48.17  ? 824  MET A SD  1 
ATOM   4194 C  CE  . MET A 1 561 ? -17.811 -57.019 -38.272 1.00 42.55  ? 824  MET A CE  1 
ATOM   4195 N  N   . GLU A 1 562 ? -18.743 -54.834 -43.926 1.00 31.85  ? 825  GLU A N   1 
ATOM   4196 C  CA  . GLU A 1 562 ? -19.433 -54.893 -45.246 1.00 39.29  ? 825  GLU A CA  1 
ATOM   4197 C  C   . GLU A 1 562 ? -20.471 -56.033 -45.254 1.00 33.79  ? 825  GLU A C   1 
ATOM   4198 O  O   . GLU A 1 562 ? -21.602 -55.797 -45.694 1.00 36.89  ? 825  GLU A O   1 
ATOM   4199 C  CB  . GLU A 1 562 ? -18.386 -55.028 -46.352 1.00 46.25  ? 825  GLU A CB  1 
ATOM   4200 C  CG  . GLU A 1 562 ? -18.970 -54.956 -47.746 1.00 55.63  ? 825  GLU A CG  1 
ATOM   4201 C  CD  . GLU A 1 562 ? -17.938 -54.963 -48.870 1.00 64.29  ? 825  GLU A CD  1 
ATOM   4202 O  OE1 . GLU A 1 562 ? -18.363 -54.973 -50.047 1.00 71.28  ? 825  GLU A OE1 1 
ATOM   4203 O  OE2 . GLU A 1 562 ? -16.713 -54.936 -48.575 1.00 72.37  ? 825  GLU A OE2 1 
ATOM   4204 N  N   . ASP A 1 563 ? -20.115 -57.208 -44.754 1.00 34.11  ? 826  ASP A N   1 
ATOM   4205 C  CA  . ASP A 1 563 ? -20.999 -58.398 -44.725 1.00 32.55  ? 826  ASP A CA  1 
ATOM   4206 C  C   . ASP A 1 563 ? -21.958 -58.264 -43.544 1.00 32.46  ? 826  ASP A C   1 
ATOM   4207 O  O   . ASP A 1 563 ? -21.476 -58.289 -42.386 1.00 33.60  ? 826  ASP A O   1 
ATOM   4208 C  CB  . ASP A 1 563 ? -20.146 -59.659 -44.623 1.00 32.69  ? 826  ASP A CB  1 
ATOM   4209 C  CG  . ASP A 1 563 ? -20.959 -60.942 -44.516 1.00 33.70  ? 826  ASP A CG  1 
ATOM   4210 O  OD1 . ASP A 1 563 ? -22.201 -60.850 -44.446 1.00 37.88  ? 826  ASP A OD1 1 
ATOM   4211 O  OD2 . ASP A 1 563 ? -20.328 -61.993 -44.425 1.00 40.07  ? 826  ASP A OD2 1 
ATOM   4212 N  N   . LYS A 1 564 ? -23.250 -58.149 -43.800 1.00 29.58  ? 827  LYS A N   1 
ATOM   4213 C  CA  . LYS A 1 564 ? -24.265 -57.908 -42.747 1.00 29.68  ? 827  LYS A CA  1 
ATOM   4214 C  C   . LYS A 1 564 ? -24.916 -59.222 -42.290 1.00 27.59  ? 827  LYS A C   1 
ATOM   4215 O  O   . LYS A 1 564 ? -25.989 -59.146 -41.657 1.00 30.67  ? 827  LYS A O   1 
ATOM   4216 C  CB  . LYS A 1 564 ? -25.317 -56.903 -43.209 1.00 29.86  ? 827  LYS A CB  1 
ATOM   4217 C  CG  . LYS A 1 564 ? -24.801 -55.536 -43.620 1.00 34.31  ? 827  LYS A CG  1 
ATOM   4218 C  CD  . LYS A 1 564 ? -23.951 -54.880 -42.568 1.00 29.20  ? 827  LYS A CD  1 
ATOM   4219 C  CE  . LYS A 1 564 ? -23.725 -53.423 -42.846 1.00 28.74  ? 827  LYS A CE  1 
ATOM   4220 N  NZ  . LYS A 1 564 ? -22.816 -52.849 -41.817 1.00 27.60  ? 827  LYS A NZ  1 
ATOM   4221 N  N   . THR A 1 565 ? -24.287 -60.367 -42.488 1.00 27.63  ? 828  THR A N   1 
ATOM   4222 C  CA  . THR A 1 565 ? -24.898 -61.660 -42.045 1.00 29.75  ? 828  THR A CA  1 
ATOM   4223 C  C   . THR A 1 565 ? -25.011 -61.661 -40.525 1.00 33.95  ? 828  THR A C   1 
ATOM   4224 O  O   . THR A 1 565 ? -23.990 -61.494 -39.856 1.00 30.41  ? 828  THR A O   1 
ATOM   4225 C  CB  . THR A 1 565 ? -24.058 -62.849 -42.496 1.00 35.01  ? 828  THR A CB  1 
ATOM   4226 O  OG1 . THR A 1 565 ? -23.906 -62.725 -43.912 1.00 35.73  ? 828  THR A OG1 1 
ATOM   4227 C  CG2 . THR A 1 565 ? -24.688 -64.170 -42.118 1.00 36.15  ? 828  THR A CG2 1 
ATOM   4228 N  N   . PRO A 1 566 ? -26.226 -61.822 -39.945 1.00 34.70  ? 829  PRO A N   1 
ATOM   4229 C  CA  . PRO A 1 566 ? -26.399 -61.803 -38.490 1.00 35.34  ? 829  PRO A CA  1 
ATOM   4230 C  C   . PRO A 1 566 ? -25.674 -62.983 -37.847 1.00 35.24  ? 829  PRO A C   1 
ATOM   4231 O  O   . PRO A 1 566 ? -25.468 -64.026 -38.474 1.00 28.34  ? 829  PRO A O   1 
ATOM   4232 C  CB  . PRO A 1 566 ? -27.921 -61.917 -38.289 1.00 36.87  ? 829  PRO A CB  1 
ATOM   4233 C  CG  . PRO A 1 566 ? -28.516 -61.530 -39.629 1.00 36.64  ? 829  PRO A CG  1 
ATOM   4234 C  CD  . PRO A 1 566 ? -27.508 -61.986 -40.646 1.00 35.99  ? 829  PRO A CD  1 
ATOM   4235 N  N   . VAL A 1 567 ? -25.260 -62.798 -36.597 1.00 32.02  ? 830  VAL A N   1 
ATOM   4236 C  CA  . VAL A 1 567 ? -24.669 -63.890 -35.793 1.00 30.96  ? 830  VAL A CA  1 
ATOM   4237 C  C   . VAL A 1 567 ? -25.847 -64.578 -35.093 1.00 31.12  ? 830  VAL A C   1 
ATOM   4238 O  O   . VAL A 1 567 ? -26.712 -63.888 -34.616 1.00 32.80  ? 830  VAL A O   1 
ATOM   4239 C  CB  . VAL A 1 567 ? -23.633 -63.285 -34.829 1.00 35.91  ? 830  VAL A CB  1 
ATOM   4240 C  CG1 . VAL A 1 567 ? -23.491 -64.094 -33.587 1.00 38.20  ? 830  VAL A CG1 1 
ATOM   4241 C  CG2 . VAL A 1 567 ? -22.309 -63.081 -35.533 1.00 34.20  ? 830  VAL A CG2 1 
ATOM   4242 N  N   . GLU A 1 568 ? -25.877 -65.905 -35.072 1.00 34.01  ? 831  GLU A N   1 
ATOM   4243 C  CA  . GLU A 1 568 ? -27.056 -66.668 -34.583 1.00 36.01  ? 831  GLU A CA  1 
ATOM   4244 C  C   . GLU A 1 568 ? -26.880 -67.062 -33.121 1.00 32.29  ? 831  GLU A C   1 
ATOM   4245 O  O   . GLU A 1 568 ? -27.901 -67.409 -32.485 1.00 29.89  ? 831  GLU A O   1 
ATOM   4246 C  CB  . GLU A 1 568 ? -27.246 -67.932 -35.437 1.00 39.90  ? 831  GLU A CB  1 
ATOM   4247 C  CG  . GLU A 1 568 ? -27.500 -67.646 -36.907 1.00 44.15  ? 831  GLU A CG  1 
ATOM   4248 C  CD  . GLU A 1 568 ? -28.859 -67.040 -37.213 1.00 47.29  ? 831  GLU A CD  1 
ATOM   4249 O  OE1 . GLU A 1 568 ? -29.789 -67.205 -36.400 1.00 51.75  ? 831  GLU A OE1 1 
ATOM   4250 O  OE2 . GLU A 1 568 ? -28.994 -66.422 -38.275 1.00 54.63  ? 831  GLU A OE2 1 
ATOM   4251 N  N   . SER A 1 569 ? -25.655 -67.071 -32.580 1.00 29.91  ? 832  SER A N   1 
ATOM   4252 C  CA  . SER A 1 569 ? -25.434 -67.473 -31.172 1.00 25.65  ? 832  SER A CA  1 
ATOM   4253 C  C   . SER A 1 569 ? -24.164 -66.822 -30.624 1.00 26.83  ? 832  SER A C   1 
ATOM   4254 O  O   . SER A 1 569 ? -23.287 -66.370 -31.423 1.00 26.32  ? 832  SER A O   1 
ATOM   4255 C  CB  . SER A 1 569 ? -25.359 -68.962 -30.999 1.00 31.69  ? 832  SER A CB  1 
ATOM   4256 O  OG  . SER A 1 569 ? -24.079 -69.456 -31.323 1.00 32.34  ? 832  SER A OG  1 
ATOM   4257 N  N   . TRP A 1 570 ? -24.084 -66.761 -29.307 1.00 25.26  ? 833  TRP A N   1 
ATOM   4258 C  CA  . TRP A 1 570 ? -22.896 -66.163 -28.625 1.00 27.35  ? 833  TRP A CA  1 
ATOM   4259 C  C   . TRP A 1 570 ? -21.631 -66.981 -28.949 1.00 29.53  ? 833  TRP A C   1 
ATOM   4260 O  O   . TRP A 1 570 ? -20.531 -66.409 -28.976 1.00 27.44  ? 833  TRP A O   1 
ATOM   4261 C  CB  . TRP A 1 570 ? -23.170 -66.047 -27.116 1.00 24.91  ? 833  TRP A CB  1 
ATOM   4262 C  CG  . TRP A 1 570 ? -24.031 -64.890 -26.751 1.00 25.34  ? 833  TRP A CG  1 
ATOM   4263 C  CD1 . TRP A 1 570 ? -25.379 -64.903 -26.526 1.00 25.37  ? 833  TRP A CD1 1 
ATOM   4264 C  CD2 . TRP A 1 570 ? -23.614 -63.512 -26.642 1.00 24.53  ? 833  TRP A CD2 1 
ATOM   4265 N  NE1 . TRP A 1 570 ? -25.817 -63.636 -26.255 1.00 27.32  ? 833  TRP A NE1 1 
ATOM   4266 C  CE2 . TRP A 1 570 ? -24.758 -62.763 -26.322 1.00 25.59  ? 833  TRP A CE2 1 
ATOM   4267 C  CE3 . TRP A 1 570 ? -22.372 -62.848 -26.740 1.00 26.65  ? 833  TRP A CE3 1 
ATOM   4268 C  CZ2 . TRP A 1 570 ? -24.706 -61.389 -26.062 1.00 28.04  ? 833  TRP A CZ2 1 
ATOM   4269 C  CZ3 . TRP A 1 570 ? -22.332 -61.485 -26.552 1.00 23.76  ? 833  TRP A CZ3 1 
ATOM   4270 C  CH2 . TRP A 1 570 ? -23.492 -60.764 -26.229 1.00 25.38  ? 833  TRP A CH2 1 
ATOM   4271 N  N   . GLU A 1 571 ? -21.731 -68.266 -29.294 1.00 28.53  ? 834  GLU A N   1 
ATOM   4272 C  CA  . GLU A 1 571 ? -20.527 -69.103 -29.582 1.00 35.05  ? 834  GLU A CA  1 
ATOM   4273 C  C   . GLU A 1 571 ? -19.847 -68.661 -30.881 1.00 30.99  ? 834  GLU A C   1 
ATOM   4274 O  O   . GLU A 1 571 ? -18.634 -68.906 -31.006 1.00 31.82  ? 834  GLU A O   1 
ATOM   4275 C  CB  . GLU A 1 571 ? -20.892 -70.593 -29.610 1.00 43.26  ? 834  GLU A CB  1 
ATOM   4276 C  CG  . GLU A 1 571 ? -21.543 -71.034 -28.306 1.00 52.67  ? 834  GLU A CG  1 
ATOM   4277 C  CD  . GLU A 1 571 ? -21.386 -72.487 -27.863 1.00 65.66  ? 834  GLU A CD  1 
ATOM   4278 O  OE1 . GLU A 1 571 ? -20.416 -73.155 -28.297 1.00 74.08  ? 834  GLU A OE1 1 
ATOM   4279 O  OE2 . GLU A 1 571 ? -22.243 -72.948 -27.058 1.00 68.56  ? 834  GLU A OE2 1 
ATOM   4280 N  N   . GLU A 1 572 ? -20.538 -67.979 -31.781 1.00 29.38  ? 835  GLU A N   1 
ATOM   4281 C  CA  . GLU A 1 572 ? -19.902 -67.363 -32.985 1.00 31.05  ? 835  GLU A CA  1 
ATOM   4282 C  C   . GLU A 1 572 ? -19.057 -66.120 -32.630 1.00 27.65  ? 835  GLU A C   1 
ATOM   4283 O  O   . GLU A 1 572 ? -18.370 -65.595 -33.527 1.00 30.58  ? 835  GLU A O   1 
ATOM   4284 C  CB  . GLU A 1 572 ? -20.929 -66.824 -33.987 1.00 33.04  ? 835  GLU A CB  1 
ATOM   4285 C  CG  . GLU A 1 572 ? -21.699 -67.894 -34.732 1.00 42.25  ? 835  GLU A CG  1 
ATOM   4286 C  CD  . GLU A 1 572 ? -22.692 -67.331 -35.760 1.00 40.47  ? 835  GLU A CD  1 
ATOM   4287 O  OE1 . GLU A 1 572 ? -22.284 -66.542 -36.645 1.00 43.86  ? 835  GLU A OE1 1 
ATOM   4288 O  OE2 . GLU A 1 572 ? -23.868 -67.666 -35.669 1.00 40.90  ? 835  GLU A OE2 1 
ATOM   4289 N  N   . ILE A 1 573 ? -19.192 -65.578 -31.428 1.00 24.12  ? 836  ILE A N   1 
ATOM   4290 C  CA  . ILE A 1 573 ? -18.556 -64.275 -31.061 1.00 24.35  ? 836  ILE A CA  1 
ATOM   4291 C  C   . ILE A 1 573 ? -17.254 -64.618 -30.342 1.00 24.20  ? 836  ILE A C   1 
ATOM   4292 O  O   . ILE A 1 573 ? -17.272 -65.314 -29.326 1.00 22.04  ? 836  ILE A O   1 
ATOM   4293 C  CB  . ILE A 1 573 ? -19.521 -63.416 -30.231 1.00 24.18  ? 836  ILE A CB  1 
ATOM   4294 C  CG1 . ILE A 1 573 ? -20.786 -63.086 -31.016 1.00 22.69  ? 836  ILE A CG1 1 
ATOM   4295 C  CG2 . ILE A 1 573 ? -18.829 -62.148 -29.712 1.00 25.74  ? 836  ILE A CG2 1 
ATOM   4296 C  CD1 . ILE A 1 573 ? -21.857 -62.385 -30.234 1.00 23.54  ? 836  ILE A CD1 1 
ATOM   4297 N  N   . PRO A 1 574 ? -16.099 -64.168 -30.881 1.00 23.91  ? 837  PRO A N   1 
ATOM   4298 C  CA  . PRO A 1 574 ? -14.791 -64.606 -30.404 1.00 23.72  ? 837  PRO A CA  1 
ATOM   4299 C  C   . PRO A 1 574 ? -14.318 -63.917 -29.104 1.00 22.08  ? 837  PRO A C   1 
ATOM   4300 O  O   . PRO A 1 574 ? -14.863 -62.913 -28.655 1.00 20.54  ? 837  PRO A O   1 
ATOM   4301 C  CB  . PRO A 1 574 ? -13.869 -64.154 -31.546 1.00 23.82  ? 837  PRO A CB  1 
ATOM   4302 C  CG  . PRO A 1 574 ? -14.504 -62.882 -32.009 1.00 26.96  ? 837  PRO A CG  1 
ATOM   4303 C  CD  . PRO A 1 574 ? -16.000 -63.138 -31.929 1.00 25.84  ? 837  PRO A CD  1 
ATOM   4304 N  N   . TYR A 1 575 ? -13.308 -64.523 -28.513 1.00 21.15  ? 838  TYR A N   1 
ATOM   4305 C  CA  . TYR A 1 575 ? -12.514 -63.949 -27.399 1.00 21.15  ? 838  TYR A CA  1 
ATOM   4306 C  C   . TYR A 1 575 ? -11.156 -63.493 -27.926 1.00 22.48  ? 838  TYR A C   1 
ATOM   4307 O  O   . TYR A 1 575 ? -10.646 -64.014 -28.994 1.00 21.38  ? 838  TYR A O   1 
ATOM   4308 C  CB  . TYR A 1 575 ? -12.298 -65.013 -26.331 1.00 21.44  ? 838  TYR A CB  1 
ATOM   4309 C  CG  . TYR A 1 575 ? -13.534 -65.541 -25.653 1.00 21.63  ? 838  TYR A CG  1 
ATOM   4310 C  CD1 . TYR A 1 575 ? -14.173 -64.793 -24.684 1.00 19.01  ? 838  TYR A CD1 1 
ATOM   4311 C  CD2 . TYR A 1 575 ? -14.030 -66.808 -25.915 1.00 27.41  ? 838  TYR A CD2 1 
ATOM   4312 C  CE1 . TYR A 1 575 ? -15.282 -65.272 -24.015 1.00 21.60  ? 838  TYR A CE1 1 
ATOM   4313 C  CE2 . TYR A 1 575 ? -15.113 -67.319 -25.222 1.00 27.92  ? 838  TYR A CE2 1 
ATOM   4314 C  CZ  . TYR A 1 575 ? -15.758 -66.531 -24.283 1.00 26.05  ? 838  TYR A CZ  1 
ATOM   4315 O  OH  . TYR A 1 575 ? -16.868 -66.948 -23.615 1.00 28.14  ? 838  TYR A OH  1 
ATOM   4316 N  N   . LEU A 1 576 ? -10.478 -62.648 -27.139 1.00 19.10  ? 839  LEU A N   1 
ATOM   4317 C  CA  . LEU A 1 576 ? -9.030  -62.429 -27.302 1.00 18.57  ? 839  LEU A CA  1 
ATOM   4318 C  C   . LEU A 1 576 ? -8.326  -63.791 -27.234 1.00 19.90  ? 839  LEU A C   1 
ATOM   4319 O  O   . LEU A 1 576 ? -8.862  -64.732 -26.615 1.00 18.86  ? 839  LEU A O   1 
ATOM   4320 C  CB  . LEU A 1 576 ? -8.515  -61.521 -26.175 1.00 20.01  ? 839  LEU A CB  1 
ATOM   4321 C  CG  . LEU A 1 576 ? -9.090  -60.108 -26.081 1.00 18.52  ? 839  LEU A CG  1 
ATOM   4322 C  CD1 . LEU A 1 576 ? -8.402  -59.314 -24.989 1.00 20.63  ? 839  LEU A CD1 1 
ATOM   4323 C  CD2 . LEU A 1 576 ? -8.987  -59.368 -27.398 1.00 22.33  ? 839  LEU A CD2 1 
ATOM   4324 N  N   . GLY A 1 577 ? -7.098  -63.882 -27.737 1.00 22.13  ? 840  GLY A N   1 
ATOM   4325 C  CA  . GLY A 1 577 ? -6.224  -65.037 -27.418 1.00 21.77  ? 840  GLY A CA  1 
ATOM   4326 C  C   . GLY A 1 577 ? -6.107  -65.218 -25.913 1.00 20.37  ? 840  GLY A C   1 
ATOM   4327 O  O   . GLY A 1 577 ? -6.174  -64.215 -25.148 1.00 19.67  ? 840  GLY A O   1 
ATOM   4328 N  N   . LYS A 1 578 ? -5.913  -66.463 -25.474 0.36 19.26  ? 841  LYS A N   1 
ATOM   4329 C  CA  . LYS A 1 578 ? -5.799  -66.826 -24.036 0.36 19.48  ? 841  LYS A CA  1 
ATOM   4330 C  C   . LYS A 1 578 ? -4.664  -66.023 -23.377 0.36 19.35  ? 841  LYS A C   1 
ATOM   4331 O  O   . LYS A 1 578 ? -4.865  -65.540 -22.256 0.36 18.40  ? 841  LYS A O   1 
ATOM   4332 C  CB  . LYS A 1 578 ? -5.569  -68.330 -23.879 0.36 19.25  ? 841  LYS A CB  1 
ATOM   4333 C  CG  . LYS A 1 578 ? -6.735  -69.225 -24.292 0.36 19.05  ? 841  LYS A CG  1 
ATOM   4334 C  CD  . LYS A 1 578 ? -6.466  -70.710 -24.059 0.36 20.11  ? 841  LYS A CD  1 
ATOM   4335 C  CE  . LYS A 1 578 ? -5.396  -71.297 -24.962 0.36 19.00  ? 841  LYS A CE  1 
ATOM   4336 N  NZ  . LYS A 1 578 ? -5.760  -71.198 -26.397 0.36 19.09  ? 841  LYS A NZ  1 
ATOM   4337 N  N   . ARG A 1 579 ? -3.516  -65.881 -24.049 1.00 19.09  ? 842  ARG A N   1 
ATOM   4338 C  CA  . ARG A 1 579 ? -2.364  -65.171 -23.483 1.00 19.61  ? 842  ARG A CA  1 
ATOM   4339 C  C   . ARG A 1 579 ? -2.645  -63.664 -23.447 1.00 18.37  ? 842  ARG A C   1 
ATOM   4340 O  O   . ARG A 1 579 ? -2.325  -63.004 -22.414 1.00 18.83  ? 842  ARG A O   1 
ATOM   4341 C  CB  . ARG A 1 579 ? -1.061  -65.529 -24.229 1.00 19.18  ? 842  ARG A CB  1 
ATOM   4342 C  CG  . ARG A 1 579 ? 0.141   -65.044 -23.455 1.00 20.56  ? 842  ARG A CG  1 
ATOM   4343 C  CD  . ARG A 1 579 ? 1.435   -65.289 -24.252 1.00 23.19  ? 842  ARG A CD  1 
ATOM   4344 N  NE  . ARG A 1 579 ? 1.559   -66.736 -24.405 1.00 24.80  ? 842  ARG A NE  1 
ATOM   4345 C  CZ  . ARG A 1 579 ? 1.982   -67.557 -23.479 1.00 30.24  ? 842  ARG A CZ  1 
ATOM   4346 N  NH1 . ARG A 1 579 ? 1.959   -68.860 -23.709 1.00 40.05  ? 842  ARG A NH1 1 
ATOM   4347 N  NH2 . ARG A 1 579 ? 2.426   -67.102 -22.329 1.00 34.17  ? 842  ARG A NH2 1 
ATOM   4348 N  N   . GLU A 1 580 ? -3.290  -63.129 -24.466 1.00 19.21  ? 843  GLU A N   1 
ATOM   4349 C  CA  . GLU A 1 580 ? -3.641  -61.673 -24.514 1.00 20.78  ? 843  GLU A CA  1 
ATOM   4350 C  C   . GLU A 1 580 ? -4.647  -61.363 -23.398 1.00 18.41  ? 843  GLU A C   1 
ATOM   4351 O  O   . GLU A 1 580 ? -4.574  -60.306 -22.792 1.00 19.07  ? 843  GLU A O   1 
ATOM   4352 C  CB  . GLU A 1 580 ? -4.247  -61.305 -25.866 1.00 22.77  ? 843  GLU A CB  1 
ATOM   4353 C  CG  . GLU A 1 580 ? -3.387  -61.576 -27.065 1.00 27.60  ? 843  GLU A CG  1 
ATOM   4354 C  CD  . GLU A 1 580 ? -4.155  -61.210 -28.330 1.00 36.64  ? 843  GLU A CD  1 
ATOM   4355 O  OE1 . GLU A 1 580 ? -5.207  -61.895 -28.671 1.00 32.30  ? 843  GLU A OE1 1 
ATOM   4356 O  OE2 . GLU A 1 580 ? -3.787  -60.165 -28.922 1.00 37.93  ? 843  GLU A OE2 1 
ATOM   4357 N  N   . ASP A 1 581 ? -5.599  -62.262 -23.163 1.00 17.71  ? 844  ASP A N   1 
ATOM   4358 C  CA  . ASP A 1 581 ? -6.636  -62.085 -22.099 1.00 18.17  ? 844  ASP A CA  1 
ATOM   4359 C  C   . ASP A 1 581 ? -5.918  -61.968 -20.738 1.00 18.78  ? 844  ASP A C   1 
ATOM   4360 O  O   . ASP A 1 581 ? -6.198  -61.061 -19.958 1.00 18.06  ? 844  ASP A O   1 
ATOM   4361 C  CB  . ASP A 1 581 ? -7.650  -63.225 -22.173 1.00 18.64  ? 844  ASP A CB  1 
ATOM   4362 C  CG  . ASP A 1 581 ? -9.070  -62.926 -21.680 1.00 19.07  ? 844  ASP A CG  1 
ATOM   4363 O  OD1 . ASP A 1 581 ? -9.269  -61.876 -21.033 1.00 17.25  ? 844  ASP A OD1 1 
ATOM   4364 O  OD2 . ASP A 1 581 ? -9.954  -63.764 -21.938 1.00 18.71  ? 844  ASP A OD2 1 
ATOM   4365 N  N   . GLN A 1 582 ? -4.937  -62.845 -20.508 0.36 19.05  ? 845  GLN A N   1 
ATOM   4366 C  CA  . GLN A 1 582 ? -4.108  -62.869 -19.275 0.36 19.54  ? 845  GLN A CA  1 
ATOM   4367 C  C   . GLN A 1 582 ? -3.256  -61.591 -19.170 0.36 18.01  ? 845  GLN A C   1 
ATOM   4368 O  O   . GLN A 1 582 ? -3.124  -61.059 -18.054 0.36 17.08  ? 845  GLN A O   1 
ATOM   4369 C  CB  . GLN A 1 582 ? -3.256  -64.141 -19.267 0.36 21.21  ? 845  GLN A CB  1 
ATOM   4370 C  CG  . GLN A 1 582 ? -2.582  -64.409 -17.936 0.36 22.90  ? 845  GLN A CG  1 
ATOM   4371 C  CD  . GLN A 1 582 ? -2.029  -65.812 -17.872 0.36 23.76  ? 845  GLN A CD  1 
ATOM   4372 O  OE1 . GLN A 1 582 ? -1.382  -66.283 -18.804 0.36 26.02  ? 845  GLN A OE1 1 
ATOM   4373 N  NE2 . GLN A 1 582 ? -2.297  -66.495 -16.773 0.36 23.81  ? 845  GLN A NE2 1 
ATOM   4374 N  N   . TRP A 1 583 ? -2.673  -61.126 -20.282 1.00 17.78  ? 846  TRP A N   1 
ATOM   4375 C  CA  . TRP A 1 583 ? -1.911  -59.845 -20.321 1.00 17.04  ? 846  TRP A CA  1 
ATOM   4376 C  C   . TRP A 1 583 ? -2.803  -58.671 -19.846 1.00 16.98  ? 846  TRP A C   1 
ATOM   4377 O  O   . TRP A 1 583 ? -2.339  -57.779 -19.105 1.00 17.54  ? 846  TRP A O   1 
ATOM   4378 C  CB  . TRP A 1 583 ? -1.365  -59.568 -21.715 1.00 18.47  ? 846  TRP A CB  1 
ATOM   4379 C  CG  . TRP A 1 583 ? -0.191  -60.442 -22.046 1.00 18.95  ? 846  TRP A CG  1 
ATOM   4380 C  CD1 . TRP A 1 583 ? 0.627   -61.073 -21.155 1.00 21.50  ? 846  TRP A CD1 1 
ATOM   4381 C  CD2 . TRP A 1 583 ? 0.349   -60.701 -23.351 1.00 19.58  ? 846  TRP A CD2 1 
ATOM   4382 N  NE1 . TRP A 1 583 ? 1.613   -61.749 -21.832 1.00 21.56  ? 846  TRP A NE1 1 
ATOM   4383 C  CE2 . TRP A 1 583 ? 1.487   -61.503 -23.168 1.00 20.01  ? 846  TRP A CE2 1 
ATOM   4384 C  CE3 . TRP A 1 583 ? -0.009  -60.318 -24.649 1.00 21.62  ? 846  TRP A CE3 1 
ATOM   4385 C  CZ2 . TRP A 1 583 ? 2.246   -61.953 -24.245 1.00 20.86  ? 846  TRP A CZ2 1 
ATOM   4386 C  CZ3 . TRP A 1 583 ? 0.738   -60.765 -25.716 1.00 22.61  ? 846  TRP A CZ3 1 
ATOM   4387 C  CH2 . TRP A 1 583 ? 1.833   -61.600 -25.508 1.00 22.02  ? 846  TRP A CH2 1 
ATOM   4388 N  N   . CYS A 1 584 ? -4.075  -58.690 -20.253 1.00 16.38  ? 847  CYS A N   1 
ATOM   4389 C  CA  . CYS A 1 584 ? -5.042  -57.606 -19.935 1.00 16.68  ? 847  CYS A CA  1 
ATOM   4390 C  C   . CYS A 1 584 ? -5.823  -57.889 -18.639 1.00 17.69  ? 847  CYS A C   1 
ATOM   4391 O  O   . CYS A 1 584 ? -6.849  -57.229 -18.409 1.00 18.52  ? 847  CYS A O   1 
ATOM   4392 C  CB  . CYS A 1 584 ? -5.920  -57.359 -21.149 1.00 17.99  ? 847  CYS A CB  1 
ATOM   4393 S  SG  . CYS A 1 584 ? -5.016  -56.567 -22.502 1.00 18.69  ? 847  CYS A SG  1 
ATOM   4394 N  N   . GLY A 1 585 ? -5.333  -58.794 -17.770 1.00 18.92  ? 848  GLY A N   1 
ATOM   4395 C  CA  . GLY A 1 585 ? -5.760  -58.957 -16.361 1.00 19.32  ? 848  GLY A CA  1 
ATOM   4396 C  C   . GLY A 1 585 ? -6.641  -60.156 -16.100 1.00 18.13  ? 848  GLY A C   1 
ATOM   4397 O  O   . GLY A 1 585 ? -7.093  -60.287 -14.951 1.00 20.17  ? 848  GLY A O   1 
ATOM   4398 N  N   . SER A 1 586 ? -6.894  -61.037 -17.075 1.00 18.29  ? 849  SER A N   1 
ATOM   4399 C  CA  . SER A 1 586 ? -7.747  -62.236 -16.881 1.00 18.32  ? 849  SER A CA  1 
ATOM   4400 C  C   . SER A 1 586 ? -7.179  -63.109 -15.739 1.00 20.28  ? 849  SER A C   1 
ATOM   4401 O  O   . SER A 1 586 ? -5.940  -63.301 -15.656 1.00 18.92  ? 849  SER A O   1 
ATOM   4402 C  CB  . SER A 1 586 ? -7.864  -63.083 -18.114 1.00 17.94  ? 849  SER A CB  1 
ATOM   4403 O  OG  . SER A 1 586 ? -8.793  -64.125 -17.884 1.00 18.81  ? 849  SER A OG  1 
ATOM   4404 N  N   . LEU A 1 587 ? -8.071  -63.774 -15.021 1.00 18.50  ? 850  LEU A N   1 
ATOM   4405 C  CA  . LEU A 1 587 ? -7.661  -64.786 -14.024 1.00 19.83  ? 850  LEU A CA  1 
ATOM   4406 C  C   . LEU A 1 587 ? -7.681  -66.212 -14.577 1.00 21.23  ? 850  LEU A C   1 
ATOM   4407 O  O   . LEU A 1 587 ? -7.475  -67.145 -13.783 1.00 23.36  ? 850  LEU A O   1 
ATOM   4408 C  CB  . LEU A 1 587 ? -8.551  -64.665 -12.778 1.00 21.21  ? 850  LEU A CB  1 
ATOM   4409 C  CG  . LEU A 1 587 ? -8.501  -63.347 -11.995 1.00 22.80  ? 850  LEU A CG  1 
ATOM   4410 C  CD1 . LEU A 1 587 ? -9.179  -63.530 -10.625 1.00 24.26  ? 850  LEU A CD1 1 
ATOM   4411 C  CD2 . LEU A 1 587 ? -7.082  -62.762 -11.852 1.00 24.81  ? 850  LEU A CD2 1 
ATOM   4412 N  N   . ILE A 1 588 ? -7.932  -66.406 -15.878 0.36 20.16  ? 851  ILE A N   1 
ATOM   4413 C  CA  . ILE A 1 588 ? -7.824  -67.765 -16.487 0.36 20.59  ? 851  ILE A CA  1 
ATOM   4414 C  C   . ILE A 1 588 ? -6.435  -68.309 -16.124 0.36 20.82  ? 851  ILE A C   1 
ATOM   4415 O  O   . ILE A 1 588 ? -5.440  -67.577 -16.301 0.36 21.35  ? 851  ILE A O   1 
ATOM   4416 C  CB  . ILE A 1 588 ? -8.097  -67.779 -18.005 0.36 19.96  ? 851  ILE A CB  1 
ATOM   4417 C  CG1 . ILE A 1 588 ? -7.164  -66.844 -18.783 0.36 19.80  ? 851  ILE A CG1 1 
ATOM   4418 C  CG2 . ILE A 1 588 ? -9.566  -67.477 -18.284 0.36 19.00  ? 851  ILE A CG2 1 
ATOM   4419 C  CD1 . ILE A 1 588 ? -7.368  -66.878 -20.276 0.36 19.89  ? 851  ILE A CD1 1 
ATOM   4420 N  N   . GLY A 1 589 ? -6.407  -69.542 -15.618 0.36 21.78  ? 852  GLY A N   1 
ATOM   4421 C  CA  . GLY A 1 589 ? -5.134  -70.164 -15.203 0.36 21.04  ? 852  GLY A CA  1 
ATOM   4422 C  C   . GLY A 1 589 ? -5.084  -70.365 -13.699 0.36 21.26  ? 852  GLY A C   1 
ATOM   4423 O  O   . GLY A 1 589 ? -4.353  -71.257 -13.252 0.36 21.38  ? 852  GLY A O   1 
ATOM   4424 N  N   . LEU A 1 590 ? -5.860  -69.572 -12.955 0.36 20.48  ? 853  LEU A N   1 
ATOM   4425 C  CA  . LEU A 1 590 ? -5.843  -69.657 -11.471 0.36 20.27  ? 853  LEU A CA  1 
ATOM   4426 C  C   . LEU A 1 590 ? -6.862  -70.691 -10.992 0.36 21.17  ? 853  LEU A C   1 
ATOM   4427 O  O   . LEU A 1 590 ? -7.949  -70.769 -11.579 0.36 20.52  ? 853  LEU A O   1 
ATOM   4428 C  CB  . LEU A 1 590 ? -6.156  -68.287 -10.864 0.36 19.59  ? 853  LEU A CB  1 
ATOM   4429 C  CG  . LEU A 1 590 ? -5.105  -67.206 -11.106 0.36 19.66  ? 853  LEU A CG  1 
ATOM   4430 C  CD1 . LEU A 1 590 ? -5.449  -65.943 -10.333 0.36 19.74  ? 853  LEU A CD1 1 
ATOM   4431 C  CD2 . LEU A 1 590 ? -3.722  -67.705 -10.716 0.36 19.68  ? 853  LEU A CD2 1 
ATOM   4432 N  N   . THR A 1 591 ? -6.504  -71.433 -9.943  0.36 21.16  ? 854  THR A N   1 
ATOM   4433 C  CA  . THR A 1 591 ? -7.448  -72.416 -9.356  0.36 21.33  ? 854  THR A CA  1 
ATOM   4434 C  C   . THR A 1 591 ? -8.694  -71.680 -8.836  0.36 21.07  ? 854  THR A C   1 
ATOM   4435 O  O   . THR A 1 591 ? -9.800  -72.213 -8.993  0.36 21.40  ? 854  THR A O   1 
ATOM   4436 C  CB  . THR A 1 591 ? -6.752  -73.215 -8.247  0.36 21.43  ? 854  THR A CB  1 
ATOM   4437 O  OG1 . THR A 1 591 ? -5.554  -73.769 -8.790  0.36 22.73  ? 854  THR A OG1 1 
ATOM   4438 C  CG2 . THR A 1 591 ? -7.625  -74.312 -7.680  0.36 22.88  ? 854  THR A CG2 1 
ATOM   4439 N  N   . SER A 1 592 ? -8.510  -70.496 -8.248  0.36 21.74  ? 855  SER A N   1 
ATOM   4440 C  CA  . SER A 1 592 ? -9.651  -69.719 -7.699  0.36 21.81  ? 855  SER A CA  1 
ATOM   4441 C  C   . SER A 1 592 ? -10.692 -69.482 -8.794  0.36 21.74  ? 855  SER A C   1 
ATOM   4442 O  O   . SER A 1 592 ? -11.890 -69.703 -8.546  0.36 21.91  ? 855  SER A O   1 
ATOM   4443 C  CB  . SER A 1 592 ? -9.165  -68.403 -7.133  0.36 22.64  ? 855  SER A CB  1 
ATOM   4444 O  OG  . SER A 1 592 ? -8.539  -67.614 -8.135  0.36 23.05  ? 855  SER A OG  1 
ATOM   4445 N  N   . ARG A 1 593 ? -10.238 -69.053 -9.964  1.00 22.81  ? 856  ARG A N   1 
ATOM   4446 C  CA  . ARG A 1 593 ? -11.137 -68.748 -11.105 1.00 21.71  ? 856  ARG A CA  1 
ATOM   4447 C  C   . ARG A 1 593 ? -11.810 -70.034 -11.608 1.00 23.78  ? 856  ARG A C   1 
ATOM   4448 O  O   . ARG A 1 593 ? -12.968 -69.990 -11.991 1.00 20.44  ? 856  ARG A O   1 
ATOM   4449 C  CB  . ARG A 1 593 ? -10.282 -68.088 -12.187 1.00 22.30  ? 856  ARG A CB  1 
ATOM   4450 C  CG  . ARG A 1 593 ? -11.065 -67.463 -13.333 1.00 20.63  ? 856  ARG A CG  1 
ATOM   4451 C  CD  . ARG A 1 593 ? -11.500 -68.431 -14.417 1.00 20.18  ? 856  ARG A CD  1 
ATOM   4452 N  NE  . ARG A 1 593 ? -12.063 -67.717 -15.551 1.00 20.44  ? 856  ARG A NE  1 
ATOM   4453 C  CZ  . ARG A 1 593 ? -12.726 -68.279 -16.552 1.00 22.55  ? 856  ARG A CZ  1 
ATOM   4454 N  NH1 . ARG A 1 593 ? -12.917 -69.585 -16.572 1.00 22.93  ? 856  ARG A NH1 1 
ATOM   4455 N  NH2 . ARG A 1 593 ? -13.211 -67.529 -17.525 1.00 22.33  ? 856  ARG A NH2 1 
ATOM   4456 N  N   . ALA A 1 594 ? -11.065 -71.146 -11.637 1.00 22.29  ? 857  ALA A N   1 
ATOM   4457 C  CA  . ALA A 1 594 ? -11.682 -72.429 -12.047 1.00 26.25  ? 857  ALA A CA  1 
ATOM   4458 C  C   . ALA A 1 594 ? -12.797 -72.839 -11.065 1.00 22.98  ? 857  ALA A C   1 
ATOM   4459 O  O   . ALA A 1 594 ? -13.793 -73.403 -11.524 1.00 24.15  ? 857  ALA A O   1 
ATOM   4460 C  CB  . ALA A 1 594 ? -10.652 -73.525 -12.163 1.00 28.64  ? 857  ALA A CB  1 
ATOM   4461 N  N   . THR A 1 595 ? -12.614 -72.605 -9.764  1.00 24.66  ? 858  THR A N   1 
ATOM   4462 C  CA  . THR A 1 595 ? -13.676 -73.064 -8.835  1.00 26.40  ? 858  THR A CA  1 
ATOM   4463 C  C   . THR A 1 595 ? -14.913 -72.189 -9.063  1.00 25.79  ? 858  THR A C   1 
ATOM   4464 O  O   . THR A 1 595 ? -16.007 -72.713 -9.110  1.00 24.78  ? 858  THR A O   1 
ATOM   4465 C  CB  . THR A 1 595 ? -13.214 -72.981 -7.381  1.00 30.39  ? 858  THR A CB  1 
ATOM   4466 O  OG1 . THR A 1 595 ? -11.962 -73.652 -7.233  1.00 36.48  ? 858  THR A OG1 1 
ATOM   4467 C  CG2 . THR A 1 595 ? -14.240 -73.533 -6.416  1.00 31.46  ? 858  THR A CG2 1 
ATOM   4468 N  N   . TRP A 1 596 ? -14.694 -70.890 -9.184  1.00 23.15  ? 859  TRP A N   1 
ATOM   4469 C  CA  . TRP A 1 596 ? -15.803 -69.939 -9.466  1.00 19.56  ? 859  TRP A CA  1 
ATOM   4470 C  C   . TRP A 1 596 ? -16.586 -70.389 -10.696 1.00 19.72  ? 859  TRP A C   1 
ATOM   4471 O  O   . TRP A 1 596 ? -17.799 -70.472 -10.632 1.00 21.16  ? 859  TRP A O   1 
ATOM   4472 C  CB  . TRP A 1 596 ? -15.171 -68.565 -9.693  1.00 20.94  ? 859  TRP A CB  1 
ATOM   4473 C  CG  . TRP A 1 596 ? -16.048 -67.452 -10.181 1.00 18.81  ? 859  TRP A CG  1 
ATOM   4474 C  CD1 . TRP A 1 596 ? -17.088 -66.867 -9.521  1.00 20.09  ? 859  TRP A CD1 1 
ATOM   4475 C  CD2 . TRP A 1 596 ? -15.884 -66.711 -11.404 1.00 19.51  ? 859  TRP A CD2 1 
ATOM   4476 N  NE1 . TRP A 1 596 ? -17.607 -65.842 -10.264 1.00 19.84  ? 859  TRP A NE1 1 
ATOM   4477 C  CE2 . TRP A 1 596 ? -16.891 -65.724 -11.426 1.00 18.33  ? 859  TRP A CE2 1 
ATOM   4478 C  CE3 . TRP A 1 596 ? -15.002 -66.801 -12.487 1.00 18.90  ? 859  TRP A CE3 1 
ATOM   4479 C  CZ2 . TRP A 1 596 ? -17.033 -64.831 -12.488 1.00 18.40  ? 859  TRP A CZ2 1 
ATOM   4480 C  CZ3 . TRP A 1 596 ? -15.145 -65.921 -13.538 1.00 19.76  ? 859  TRP A CZ3 1 
ATOM   4481 C  CH2 . TRP A 1 596 ? -16.152 -64.954 -13.537 1.00 19.59  ? 859  TRP A CH2 1 
ATOM   4482 N  N   . ALA A 1 597 ? -15.882 -70.602 -11.800 1.00 20.67  ? 860  ALA A N   1 
ATOM   4483 C  CA  . ALA A 1 597 ? -16.574 -70.955 -13.060 1.00 21.91  ? 860  ALA A CA  1 
ATOM   4484 C  C   . ALA A 1 597 ? -17.343 -72.280 -12.909 1.00 23.76  ? 860  ALA A C   1 
ATOM   4485 O  O   . ALA A 1 597 ? -18.511 -72.333 -13.265 1.00 23.41  ? 860  ALA A O   1 
ATOM   4486 C  CB  . ALA A 1 597 ? -15.562 -71.013 -14.181 1.00 22.56  ? 860  ALA A CB  1 
ATOM   4487 N  N   . LYS A 1 598 ? -16.683 -73.314 -12.398 1.00 24.28  ? 861  LYS A N   1 
ATOM   4488 C  CA  . LYS A 1 598 ? -17.359 -74.630 -12.281 1.00 26.50  ? 861  LYS A CA  1 
ATOM   4489 C  C   . LYS A 1 598 ? -18.547 -74.560 -11.315 1.00 25.76  ? 861  LYS A C   1 
ATOM   4490 O  O   . LYS A 1 598 ? -19.520 -75.264 -11.555 1.00 28.59  ? 861  LYS A O   1 
ATOM   4491 C  CB  . LYS A 1 598 ? -16.382 -75.698 -11.791 1.00 32.41  ? 861  LYS A CB  1 
ATOM   4492 C  CG  . LYS A 1 598 ? -16.975 -77.073 -11.540 1.00 39.49  ? 861  LYS A CG  1 
ATOM   4493 C  CD  . LYS A 1 598 ? -15.949 -78.060 -11.041 1.00 47.76  ? 861  LYS A CD  1 
ATOM   4494 C  CE  . LYS A 1 598 ? -15.933 -79.352 -11.834 1.00 60.42  ? 861  LYS A CE  1 
ATOM   4495 N  NZ  . LYS A 1 598 ? -17.274 -79.979 -11.892 1.00 57.74  ? 861  LYS A NZ  1 
ATOM   4496 N  N   . ASN A 1 599 ? -18.483 -73.747 -10.272 1.00 25.46  ? 862  ASN A N   1 
ATOM   4497 C  CA  . ASN A 1 599 ? -19.543 -73.667 -9.240  1.00 24.35  ? 862  ASN A CA  1 
ATOM   4498 C  C   . ASN A 1 599 ? -20.454 -72.452 -9.469  1.00 22.25  ? 862  ASN A C   1 
ATOM   4499 O  O   . ASN A 1 599 ? -21.186 -72.089 -8.541  1.00 22.06  ? 862  ASN A O   1 
ATOM   4500 C  CB  . ASN A 1 599 ? -18.925 -73.616 -7.849  1.00 26.29  ? 862  ASN A CB  1 
ATOM   4501 C  CG  . ASN A 1 599 ? -18.258 -74.934 -7.510  1.00 33.26  ? 862  ASN A CG  1 
ATOM   4502 O  OD1 . ASN A 1 599 ? -18.814 -75.994 -7.763  1.00 36.78  ? 862  ASN A OD1 1 
ATOM   4503 N  ND2 . ASN A 1 599 ? -17.098 -74.871 -6.920  1.00 40.02  ? 862  ASN A ND2 1 
ATOM   4504 N  N   . ILE A 1 600 ? -20.466 -71.855 -10.651 1.00 23.08  ? 863  ILE A N   1 
ATOM   4505 C  CA  . ILE A 1 600 ? -21.170 -70.541 -10.841 1.00 20.85  ? 863  ILE A CA  1 
ATOM   4506 C  C   . ILE A 1 600 ? -22.682 -70.632 -10.511 1.00 22.22  ? 863  ILE A C   1 
ATOM   4507 O  O   . ILE A 1 600 ? -23.263 -69.653 -10.013 1.00 20.10  ? 863  ILE A O   1 
ATOM   4508 C  CB  . ILE A 1 600 ? -20.893 -69.946 -12.226 1.00 19.07  ? 863  ILE A CB  1 
ATOM   4509 C  CG1 . ILE A 1 600 ? -21.207 -68.445 -12.271 1.00 21.51  ? 863  ILE A CG1 1 
ATOM   4510 C  CG2 . ILE A 1 600 ? -21.617 -70.670 -13.379 1.00 21.38  ? 863  ILE A CG2 1 
ATOM   4511 C  CD1 . ILE A 1 600 ? -20.310 -67.624 -11.431 1.00 20.70  ? 863  ILE A CD1 1 
ATOM   4512 N  N   A GLN A 1 601 ? -23.328 -71.772 -10.786 0.25 21.79  ? 864  GLN A N   1 
ATOM   4513 N  N   B GLN A 1 601 ? -23.325 -71.773 -10.779 0.25 21.64  ? 864  GLN A N   1 
ATOM   4514 C  CA  A GLN A 1 601 ? -24.785 -71.921 -10.506 0.25 23.13  ? 864  GLN A CA  1 
ATOM   4515 C  CA  B GLN A 1 601 ? -24.786 -71.910 -10.520 0.25 22.88  ? 864  GLN A CA  1 
ATOM   4516 C  C   A GLN A 1 601 ? -25.050 -71.751 -9.002  0.25 22.39  ? 864  GLN A C   1 
ATOM   4517 C  C   B GLN A 1 601 ? -25.059 -71.774 -9.009  0.25 22.30  ? 864  GLN A C   1 
ATOM   4518 O  O   A GLN A 1 601 ? -26.107 -71.198 -8.650  0.25 22.41  ? 864  GLN A O   1 
ATOM   4519 O  O   B GLN A 1 601 ? -26.129 -71.247 -8.656  0.25 22.51  ? 864  GLN A O   1 
ATOM   4520 C  CB  A GLN A 1 601 ? -25.319 -73.251 -11.036 0.25 24.30  ? 864  GLN A CB  1 
ATOM   4521 C  CB  B GLN A 1 601 ? -25.320 -73.203 -11.139 0.25 23.74  ? 864  GLN A CB  1 
ATOM   4522 C  CG  A GLN A 1 601 ? -25.287 -73.347 -12.554 0.25 25.23  ? 864  GLN A CG  1 
ATOM   4523 C  CG  B GLN A 1 601 ? -26.840 -73.272 -11.215 0.25 24.58  ? 864  GLN A CG  1 
ATOM   4524 C  CD  A GLN A 1 601 ? -26.270 -72.433 -13.243 0.25 26.26  ? 864  GLN A CD  1 
ATOM   4525 C  CD  B GLN A 1 601 ? -27.492 -72.077 -11.862 0.25 25.00  ? 864  GLN A CD  1 
ATOM   4526 O  OE1 A GLN A 1 601 ? -27.198 -71.906 -12.635 0.25 28.38  ? 864  GLN A OE1 1 
ATOM   4527 O  OE1 B GLN A 1 601 ? -27.187 -71.704 -12.995 0.25 25.76  ? 864  GLN A OE1 1 
ATOM   4528 N  NE2 A GLN A 1 601 ? -26.085 -72.268 -14.543 0.25 27.25  ? 864  GLN A NE2 1 
ATOM   4529 N  NE2 B GLN A 1 601 ? -28.425 -71.480 -11.139 0.25 24.58  ? 864  GLN A NE2 1 
ATOM   4530 N  N   . THR A 1 602 ? -24.126 -72.186 -8.143  1.00 22.62  ? 865  THR A N   1 
ATOM   4531 C  CA  . THR A 1 602 ? -24.249 -71.998 -6.674  1.00 25.85  ? 865  THR A CA  1 
ATOM   4532 C  C   . THR A 1 602 ? -24.221 -70.505 -6.306  1.00 24.55  ? 865  THR A C   1 
ATOM   4533 O  O   . THR A 1 602 ? -24.944 -70.086 -5.402  1.00 23.48  ? 865  THR A O   1 
ATOM   4534 C  CB  . THR A 1 602 ? -23.165 -72.765 -5.917  1.00 29.64  ? 865  THR A CB  1 
ATOM   4535 O  OG1 . THR A 1 602 ? -23.317 -74.120 -6.367  1.00 34.59  ? 865  THR A OG1 1 
ATOM   4536 C  CG2 . THR A 1 602 ? -23.349 -72.646 -4.431  1.00 33.79  ? 865  THR A CG2 1 
ATOM   4537 N  N   . ALA A 1 603 ? -23.412 -69.704 -6.986  1.00 23.39  ? 866  ALA A N   1 
ATOM   4538 C  CA  . ALA A 1 603 ? -23.302 -68.255 -6.719  1.00 21.51  ? 866  ALA A CA  1 
ATOM   4539 C  C   . ALA A 1 603 ? -24.573 -67.582 -7.199  1.00 19.10  ? 866  ALA A C   1 
ATOM   4540 O  O   . ALA A 1 603 ? -25.194 -66.761 -6.482  1.00 21.09  ? 866  ALA A O   1 
ATOM   4541 C  CB  . ALA A 1 603 ? -22.127 -67.708 -7.463  1.00 22.21  ? 866  ALA A CB  1 
ATOM   4542 N  N   . ILE A 1 604 ? -25.009 -67.990 -8.384  1.00 21.59  ? 867  ILE A N   1 
ATOM   4543 C  CA  . ILE A 1 604 ? -26.250 -67.453 -9.019  1.00 20.56  ? 867  ILE A CA  1 
ATOM   4544 C  C   . ILE A 1 604 ? -27.422 -67.724 -8.066  1.00 21.77  ? 867  ILE A C   1 
ATOM   4545 O  O   . ILE A 1 604 ? -28.192 -66.780 -7.755  1.00 19.85  ? 867  ILE A O   1 
ATOM   4546 C  CB  . ILE A 1 604 ? -26.451 -68.043 -10.421 1.00 20.09  ? 867  ILE A CB  1 
ATOM   4547 C  CG1 . ILE A 1 604 ? -25.426 -67.479 -11.401 1.00 19.81  ? 867  ILE A CG1 1 
ATOM   4548 C  CG2 . ILE A 1 604 ? -27.862 -67.783 -10.941 1.00 21.37  ? 867  ILE A CG2 1 
ATOM   4549 C  CD1 . ILE A 1 604 ? -25.341 -68.263 -12.666 1.00 22.23  ? 867  ILE A CD1 1 
ATOM   4550 N  N   . ASN A 1 605 ? -27.475 -68.944 -7.533  1.00 22.92  ? 868  ASN A N   1 
ATOM   4551 C  CA  . ASN A 1 605 ? -28.571 -69.371 -6.617  1.00 23.94  ? 868  ASN A CA  1 
ATOM   4552 C  C   . ASN A 1 605 ? -28.480 -68.589 -5.298  1.00 22.24  ? 868  ASN A C   1 
ATOM   4553 O  O   . ASN A 1 605 ? -29.540 -68.304 -4.735  1.00 20.81  ? 868  ASN A O   1 
ATOM   4554 C  CB  . ASN A 1 605 ? -28.540 -70.887 -6.404  1.00 25.42  ? 868  ASN A CB  1 
ATOM   4555 C  CG  . ASN A 1 605 ? -29.025 -71.651 -7.627  1.00 31.39  ? 868  ASN A CG  1 
ATOM   4556 O  OD1 . ASN A 1 605 ? -29.667 -71.118 -8.536  1.00 37.00  ? 868  ASN A OD1 1 
ATOM   4557 N  ND2 . ASN A 1 605 ? -28.725 -72.927 -7.658  1.00 38.15  ? 868  ASN A ND2 1 
ATOM   4558 N  N   . GLN A 1 606 ? -27.286 -68.246 -4.807  1.00 21.23  ? 869  GLN A N   1 
ATOM   4559 C  CA  . GLN A 1 606 ? -27.169 -67.447 -3.578  1.00 20.22  ? 869  GLN A CA  1 
ATOM   4560 C  C   . GLN A 1 606 ? -27.865 -66.104 -3.779  1.00 19.84  ? 869  GLN A C   1 
ATOM   4561 O  O   . GLN A 1 606 ? -28.643 -65.646 -2.882  1.00 21.63  ? 869  GLN A O   1 
ATOM   4562 C  CB  . GLN A 1 606 ? -25.716 -67.244 -3.144  1.00 21.08  ? 869  GLN A CB  1 
ATOM   4563 C  CG  . GLN A 1 606 ? -25.612 -66.480 -1.841  1.00 24.01  ? 869  GLN A CG  1 
ATOM   4564 C  CD  . GLN A 1 606 ? -24.200 -66.154 -1.398  1.00 29.42  ? 869  GLN A CD  1 
ATOM   4565 O  OE1 . GLN A 1 606 ? -23.283 -66.011 -2.214  1.00 28.77  ? 869  GLN A OE1 1 
ATOM   4566 N  NE2 . GLN A 1 606 ? -24.028 -65.986 -0.096  1.00 27.21  ? 869  GLN A NE2 1 
ATOM   4567 N  N   . VAL A 1 607 ? -27.599 -65.445 -4.901  1.00 19.64  ? 870  VAL A N   1 
ATOM   4568 C  CA  . VAL A 1 607 ? -28.173 -64.118 -5.178  1.00 18.23  ? 870  VAL A CA  1 
ATOM   4569 C  C   . VAL A 1 607 ? -29.692 -64.245 -5.432  1.00 17.66  ? 870  VAL A C   1 
ATOM   4570 O  O   . VAL A 1 607 ? -30.471 -63.447 -4.842  1.00 19.41  ? 870  VAL A O   1 
ATOM   4571 C  CB  . VAL A 1 607 ? -27.427 -63.428 -6.326  1.00 19.11  ? 870  VAL A CB  1 
ATOM   4572 C  CG1 . VAL A 1 607 ? -28.154 -62.171 -6.723  1.00 19.58  ? 870  VAL A CG1 1 
ATOM   4573 C  CG2 . VAL A 1 607 ? -25.996 -63.152 -5.898  1.00 20.20  ? 870  VAL A CG2 1 
ATOM   4574 N  N   . ARG A 1 608 ? -30.122 -65.272 -6.177  1.00 18.75  ? 871  ARG A N   1 
ATOM   4575 C  CA  . ARG A 1 608 ? -31.587 -65.476 -6.407  1.00 21.20  ? 871  ARG A CA  1 
ATOM   4576 C  C   . ARG A 1 608 ? -32.309 -65.679 -5.068  1.00 22.40  ? 871  ARG A C   1 
ATOM   4577 O  O   . ARG A 1 608 ? -33.413 -65.149 -4.926  1.00 23.62  ? 871  ARG A O   1 
ATOM   4578 C  CB  . ARG A 1 608 ? -31.846 -66.672 -7.329  1.00 20.42  ? 871  ARG A CB  1 
ATOM   4579 C  CG  . ARG A 1 608 ? -31.420 -66.443 -8.770  1.00 21.01  ? 871  ARG A CG  1 
ATOM   4580 C  CD  . ARG A 1 608 ? -31.701 -67.713 -9.544  1.00 22.93  ? 871  ARG A CD  1 
ATOM   4581 N  NE  . ARG A 1 608 ? -31.554 -67.540 -10.966 1.00 23.45  ? 871  ARG A NE  1 
ATOM   4582 C  CZ  . ARG A 1 608 ? -31.460 -68.539 -11.835 1.00 28.84  ? 871  ARG A CZ  1 
ATOM   4583 N  NH1 . ARG A 1 608 ? -31.504 -69.796 -11.418 1.00 33.28  ? 871  ARG A NH1 1 
ATOM   4584 N  NH2 . ARG A 1 608 ? -31.320 -68.287 -13.121 1.00 26.61  ? 871  ARG A NH2 1 
ATOM   4585 N  N   . SER A 1 609 ? -31.718 -66.413 -4.137  1.00 22.20  ? 872  SER A N   1 
ATOM   4586 C  CA  . SER A 1 609 ? -32.341 -66.656 -2.800  1.00 23.80  ? 872  SER A CA  1 
ATOM   4587 C  C   . SER A 1 609 ? -32.460 -65.347 -2.023  1.00 20.81  ? 872  SER A C   1 
ATOM   4588 O  O   . SER A 1 609 ? -33.399 -65.194 -1.215  1.00 21.02  ? 872  SER A O   1 
ATOM   4589 C  CB  . SER A 1 609 ? -31.577 -67.697 -2.027  1.00 23.43  ? 872  SER A CB  1 
ATOM   4590 O  OG  . SER A 1 609 ? -31.597 -68.954 -2.703  1.00 25.36  ? 872  SER A OG  1 
ATOM   4591 N  N   . LEU A 1 610 ? -31.504 -64.424 -2.140  1.00 20.18  ? 873  LEU A N   1 
ATOM   4592 C  CA  . LEU A 1 610 ? -31.597 -63.121 -1.444  1.00 19.63  ? 873  LEU A CA  1 
ATOM   4593 C  C   . LEU A 1 610 ? -32.705 -62.262 -2.083  1.00 20.83  ? 873  LEU A C   1 
ATOM   4594 O  O   . LEU A 1 610 ? -33.440 -61.579 -1.362  1.00 20.25  ? 873  LEU A O   1 
ATOM   4595 C  CB  . LEU A 1 610 ? -30.224 -62.447 -1.504  1.00 21.12  ? 873  LEU A CB  1 
ATOM   4596 C  CG  . LEU A 1 610 ? -29.122 -63.133 -0.692  1.00 19.97  ? 873  LEU A CG  1 
ATOM   4597 C  CD1 . LEU A 1 610 ? -27.776 -62.537 -1.052  1.00 22.70  ? 873  LEU A CD1 1 
ATOM   4598 C  CD2 . LEU A 1 610 ? -29.337 -63.009 0.805   1.00 22.29  ? 873  LEU A CD2 1 
ATOM   4599 N  N   . ILE A 1 611 ? -32.798 -62.238 -3.413  1.00 22.07  ? 874  ILE A N   1 
ATOM   4600 C  CA  . ILE A 1 611 ? -33.760 -61.347 -4.131  1.00 21.54  ? 874  ILE A CA  1 
ATOM   4601 C  C   . ILE A 1 611 ? -35.162 -61.929 -3.928  1.00 24.02  ? 874  ILE A C   1 
ATOM   4602 O  O   . ILE A 1 611 ? -36.116 -61.131 -3.699  1.00 23.00  ? 874  ILE A O   1 
ATOM   4603 C  CB  . ILE A 1 611 ? -33.368 -61.190 -5.616  1.00 23.16  ? 874  ILE A CB  1 
ATOM   4604 C  CG1 . ILE A 1 611 ? -32.055 -60.420 -5.728  1.00 22.90  ? 874  ILE A CG1 1 
ATOM   4605 C  CG2 . ILE A 1 611 ? -34.475 -60.487 -6.403  1.00 22.98  ? 874  ILE A CG2 1 
ATOM   4606 C  CD1 . ILE A 1 611 ? -31.486 -60.249 -7.114  1.00 25.48  ? 874  ILE A CD1 1 
ATOM   4607 N  N   . GLY A 1 612 ? -35.284 -63.242 -3.958  1.00 22.29  ? 875  GLY A N   1 
ATOM   4608 C  CA  . GLY A 1 612 ? -36.539 -63.954 -3.606  1.00 26.86  ? 875  GLY A CA  1 
ATOM   4609 C  C   . GLY A 1 612 ? -37.203 -64.610 -4.807  1.00 27.42  ? 875  GLY A C   1 
ATOM   4610 O  O   . GLY A 1 612 ? -36.608 -64.781 -5.869  1.00 25.73  ? 875  GLY A O   1 
ATOM   4611 N  N   . ASN A 1 613 ? -38.502 -64.872 -4.702  1.00 28.21  ? 876  ASN A N   1 
ATOM   4612 C  CA  . ASN A 1 613 ? -39.207 -65.729 -5.693  1.00 29.91  ? 876  ASN A CA  1 
ATOM   4613 C  C   . ASN A 1 613 ? -39.712 -64.865 -6.863  1.00 33.79  ? 876  ASN A C   1 
ATOM   4614 O  O   . ASN A 1 613 ? -40.852 -64.380 -6.849  1.00 37.12  ? 876  ASN A O   1 
ATOM   4615 C  CB  . ASN A 1 613 ? -40.335 -66.473 -4.968  1.00 36.28  ? 876  ASN A CB  1 
ATOM   4616 C  CG  . ASN A 1 613 ? -41.035 -67.482 -5.856  1.00 42.37  ? 876  ASN A CG  1 
ATOM   4617 O  OD1 . ASN A 1 613 ? -40.455 -67.985 -6.811  1.00 38.90  ? 876  ASN A OD1 1 
ATOM   4618 N  ND2 . ASN A 1 613 ? -42.262 -67.841 -5.496  1.00 49.12  ? 876  ASN A ND2 1 
ATOM   4619 N  N   . GLU A 1 614 ? -38.906 -64.738 -7.899  1.00 25.22  ? 877  GLU A N   1 
ATOM   4620 C  CA  . GLU A 1 614 ? -39.080 -63.823 -9.022  1.00 22.75  ? 877  GLU A CA  1 
ATOM   4621 C  C   . GLU A 1 614 ? -38.896 -64.672 -10.273 1.00 22.27  ? 877  GLU A C   1 
ATOM   4622 O  O   . GLU A 1 614 ? -38.543 -65.868 -10.154 1.00 26.86  ? 877  GLU A O   1 
ATOM   4623 C  CB  . GLU A 1 614 ? -38.012 -62.718 -8.949  1.00 23.48  ? 877  GLU A CB  1 
ATOM   4624 C  CG  . GLU A 1 614 ? -38.181 -61.772 -7.786  1.00 23.64  ? 877  GLU A CG  1 
ATOM   4625 C  CD  . GLU A 1 614 ? -39.380 -60.833 -7.779  1.00 27.64  ? 877  GLU A CD  1 
ATOM   4626 O  OE1 . GLU A 1 614 ? -39.986 -60.588 -8.832  1.00 25.30  ? 877  GLU A OE1 1 
ATOM   4627 O  OE2 . GLU A 1 614 ? -39.626 -60.263 -6.706  1.00 27.97  ? 877  GLU A OE2 1 
ATOM   4628 N  N   . GLU A 1 615 ? -39.137 -64.109 -11.433 1.00 27.19  ? 878  GLU A N   1 
ATOM   4629 C  CA  . GLU A 1 615 ? -38.911 -64.866 -12.692 1.00 27.90  ? 878  GLU A CA  1 
ATOM   4630 C  C   . GLU A 1 615 ? -37.456 -64.612 -13.122 1.00 24.91  ? 878  GLU A C   1 
ATOM   4631 O  O   . GLU A 1 615 ? -37.143 -63.431 -13.392 1.00 26.49  ? 878  GLU A O   1 
ATOM   4632 C  CB  . GLU A 1 615 ? -39.832 -64.398 -13.826 1.00 33.07  ? 878  GLU A CB  1 
ATOM   4633 C  CG  . GLU A 1 615 ? -39.634 -65.228 -15.097 1.00 42.57  ? 878  GLU A CG  1 
ATOM   4634 C  CD  . GLU A 1 615 ? -40.439 -64.833 -16.337 1.00 54.55  ? 878  GLU A CD  1 
ATOM   4635 O  OE1 . GLU A 1 615 ? -41.406 -64.028 -16.213 1.00 48.98  ? 878  GLU A OE1 1 
ATOM   4636 O  OE2 . GLU A 1 615 ? -40.095 -65.329 -17.447 1.00 64.41  ? 878  GLU A OE2 1 
ATOM   4637 N  N   . TYR A 1 616 ? -36.681 -65.680 -13.277 1.00 26.45  ? 879  TYR A N   1 
ATOM   4638 C  CA  . TYR A 1 616 ? -35.256 -65.658 -13.719 1.00 26.99  ? 879  TYR A CA  1 
ATOM   4639 C  C   . TYR A 1 616 ? -35.086 -66.492 -14.982 1.00 30.15  ? 879  TYR A C   1 
ATOM   4640 O  O   . TYR A 1 616 ? -35.853 -67.409 -15.223 1.00 27.62  ? 879  TYR A O   1 
ATOM   4641 C  CB  . TYR A 1 616 ? -34.373 -66.239 -12.626 1.00 25.77  ? 879  TYR A CB  1 
ATOM   4642 C  CG  . TYR A 1 616 ? -34.476 -65.551 -11.294 1.00 23.28  ? 879  TYR A CG  1 
ATOM   4643 C  CD1 . TYR A 1 616 ? -33.709 -64.437 -10.995 1.00 21.79  ? 879  TYR A CD1 1 
ATOM   4644 C  CD2 . TYR A 1 616 ? -35.268 -66.074 -10.283 1.00 24.57  ? 879  TYR A CD2 1 
ATOM   4645 C  CE1 . TYR A 1 616 ? -33.762 -63.846 -9.738  1.00 24.69  ? 879  TYR A CE1 1 
ATOM   4646 C  CE2 . TYR A 1 616 ? -35.336 -65.493 -9.023  1.00 21.51  ? 879  TYR A CE2 1 
ATOM   4647 C  CZ  . TYR A 1 616 ? -34.587 -64.370 -8.746  1.00 22.51  ? 879  TYR A CZ  1 
ATOM   4648 O  OH  . TYR A 1 616 ? -34.647 -63.784 -7.510  1.00 24.36  ? 879  TYR A OH  1 
ATOM   4649 N  N   . THR A 1 617 ? -34.084 -66.138 -15.786 1.00 28.12  ? 880  THR A N   1 
ATOM   4650 C  CA  . THR A 1 617 ? -33.627 -66.883 -16.995 1.00 30.33  ? 880  THR A CA  1 
ATOM   4651 C  C   . THR A 1 617 ? -32.211 -67.414 -16.725 1.00 29.32  ? 880  THR A C   1 
ATOM   4652 O  O   . THR A 1 617 ? -31.429 -66.677 -16.086 1.00 27.50  ? 880  THR A O   1 
ATOM   4653 C  CB  . THR A 1 617 ? -33.638 -65.943 -18.202 1.00 32.92  ? 880  THR A CB  1 
ATOM   4654 O  OG1 . THR A 1 617 ? -34.958 -65.401 -18.331 1.00 32.47  ? 880  THR A OG1 1 
ATOM   4655 C  CG2 . THR A 1 617 ? -33.225 -66.618 -19.497 1.00 32.99  ? 880  THR A CG2 1 
ATOM   4656 N  N   . ASP A 1 618 ? -31.910 -68.644 -17.136 1.00 26.95  ? 881  ASP A N   1 
ATOM   4657 C  CA  . ASP A 1 618 ? -30.519 -69.160 -17.113 1.00 30.88  ? 881  ASP A CA  1 
ATOM   4658 C  C   . ASP A 1 618 ? -29.824 -68.757 -18.424 1.00 29.83  ? 881  ASP A C   1 
ATOM   4659 O  O   . ASP A 1 618 ? -30.114 -69.367 -19.470 1.00 27.44  ? 881  ASP A O   1 
ATOM   4660 C  CB  . ASP A 1 618 ? -30.514 -70.676 -16.901 1.00 33.81  ? 881  ASP A CB  1 
ATOM   4661 C  CG  . ASP A 1 618 ? -29.117 -71.276 -16.792 1.00 39.47  ? 881  ASP A CG  1 
ATOM   4662 O  OD1 . ASP A 1 618 ? -28.127 -70.505 -16.541 1.00 34.22  ? 881  ASP A OD1 1 
ATOM   4663 O  OD2 . ASP A 1 618 ? -29.020 -72.511 -16.979 1.00 41.10  ? 881  ASP A OD2 1 
ATOM   4664 N  N   . TYR A 1 619 ? -28.868 -67.823 -18.370 1.00 27.81  ? 882  TYR A N   1 
ATOM   4665 C  CA  . TYR A 1 619 ? -28.059 -67.445 -19.558 1.00 27.35  ? 882  TYR A CA  1 
ATOM   4666 C  C   . TYR A 1 619 ? -26.762 -68.258 -19.640 1.00 30.14  ? 882  TYR A C   1 
ATOM   4667 O  O   . TYR A 1 619 ? -26.053 -68.078 -20.654 1.00 28.30  ? 882  TYR A O   1 
ATOM   4668 C  CB  . TYR A 1 619 ? -27.774 -65.946 -19.530 1.00 28.61  ? 882  TYR A CB  1 
ATOM   4669 C  CG  . TYR A 1 619 ? -29.013 -65.114 -19.702 1.00 31.07  ? 882  TYR A CG  1 
ATOM   4670 C  CD1 . TYR A 1 619 ? -29.651 -65.054 -20.935 1.00 30.48  ? 882  TYR A CD1 1 
ATOM   4671 C  CD2 . TYR A 1 619 ? -29.550 -64.388 -18.658 1.00 26.82  ? 882  TYR A CD2 1 
ATOM   4672 C  CE1 . TYR A 1 619 ? -30.798 -64.300 -21.128 1.00 29.79  ? 882  TYR A CE1 1 
ATOM   4673 C  CE2 . TYR A 1 619 ? -30.709 -63.643 -18.833 1.00 27.26  ? 882  TYR A CE2 1 
ATOM   4674 C  CZ  . TYR A 1 619 ? -31.324 -63.581 -20.072 1.00 32.79  ? 882  TYR A CZ  1 
ATOM   4675 O  OH  . TYR A 1 619 ? -32.428 -62.798 -20.232 1.00 32.16  ? 882  TYR A OH  1 
ATOM   4676 N  N   . MET A 1 620 ? -26.418 -69.115 -18.663 1.00 30.26  ? 883  MET A N   1 
ATOM   4677 C  CA  . MET A 1 620 ? -25.093 -69.785 -18.687 1.00 29.97  ? 883  MET A CA  1 
ATOM   4678 C  C   . MET A 1 620 ? -24.973 -70.742 -19.887 1.00 33.23  ? 883  MET A C   1 
ATOM   4679 O  O   . MET A 1 620 ? -23.892 -70.764 -20.485 1.00 34.57  ? 883  MET A O   1 
ATOM   4680 C  CB  . MET A 1 620 ? -24.697 -70.483 -17.383 1.00 29.48  ? 883  MET A CB  1 
ATOM   4681 C  CG  . MET A 1 620 ? -24.775 -69.609 -16.130 1.00 29.17  ? 883  MET A CG  1 
ATOM   4682 S  SD  . MET A 1 620 ? -24.018 -67.939 -16.290 1.00 28.48  ? 883  MET A SD  1 
ATOM   4683 C  CE  . MET A 1 620 ? -22.280 -68.321 -16.480 1.00 28.06  ? 883  MET A CE  1 
ATOM   4684 N  N   . PRO A 1 621 ? -26.001 -71.508 -20.341 1.00 36.27  ? 884  PRO A N   1 
ATOM   4685 C  CA  . PRO A 1 621 ? -25.830 -72.391 -21.510 1.00 40.13  ? 884  PRO A CA  1 
ATOM   4686 C  C   . PRO A 1 621 ? -25.614 -71.717 -22.881 1.00 43.36  ? 884  PRO A C   1 
ATOM   4687 O  O   . PRO A 1 621 ? -25.386 -72.471 -23.827 1.00 47.88  ? 884  PRO A O   1 
ATOM   4688 C  CB  . PRO A 1 621 ? -27.124 -73.238 -21.563 1.00 40.07  ? 884  PRO A CB  1 
ATOM   4689 C  CG  . PRO A 1 621 ? -27.757 -73.093 -20.185 1.00 41.18  ? 884  PRO A CG  1 
ATOM   4690 C  CD  . PRO A 1 621 ? -27.312 -71.725 -19.691 1.00 41.70  ? 884  PRO A CD  1 
ATOM   4691 N  N   . SER A 1 622 ? -25.640 -70.368 -22.958 1.00 38.22  ? 885  SER A N   1 
ATOM   4692 C  CA  . SER A 1 622 ? -25.169 -69.549 -24.117 1.00 42.09  ? 885  SER A CA  1 
ATOM   4693 C  C   . SER A 1 622 ? -23.643 -69.656 -24.252 1.00 44.07  ? 885  SER A C   1 
ATOM   4694 O  O   . SER A 1 622 ? -23.100 -69.207 -25.306 1.00 42.73  ? 885  SER A O   1 
ATOM   4695 C  CB  . SER A 1 622 ? -25.593 -68.107 -24.014 1.00 43.86  ? 885  SER A CB  1 
ATOM   4696 O  OG  . SER A 1 622 ? -24.853 -67.396 -23.011 1.00 37.10  ? 885  SER A OG  1 
ATOM   4697 N  N   . MET A 1 623 ? -22.976 -70.223 -23.237 1.00 40.10  ? 886  MET A N   1 
ATOM   4698 C  CA  . MET A 1 623 ? -21.517 -70.503 -23.254 1.00 46.46  ? 886  MET A CA  1 
ATOM   4699 C  C   . MET A 1 623 ? -21.283 -72.009 -23.455 1.00 50.09  ? 886  MET A C   1 
ATOM   4700 O  O   . MET A 1 623 ? -21.910 -72.817 -22.723 1.00 41.65  ? 886  MET A O   1 
ATOM   4701 C  CB  . MET A 1 623 ? -20.865 -70.080 -21.933 1.00 47.97  ? 886  MET A CB  1 
ATOM   4702 C  CG  . MET A 1 623 ? -21.412 -68.798 -21.382 1.00 48.79  ? 886  MET A CG  1 
ATOM   4703 S  SD  . MET A 1 623 ? -20.401 -68.228 -19.988 1.00 40.94  ? 886  MET A SD  1 
ATOM   4704 C  CE  . MET A 1 623 ? -19.102 -67.416 -20.869 1.00 39.73  ? 886  MET A CE  1 
ATOM   4705 N  N   . LYS A 1 624 ? -20.327 -72.351 -24.322 1.00 53.99  ? 887  LYS A N   1 
ATOM   4706 C  CA  . LYS A 1 624 ? -19.951 -73.749 -24.682 1.00 55.70  ? 887  LYS A CA  1 
ATOM   4707 C  C   . LYS A 1 624 ? -19.869 -74.688 -23.456 1.00 52.20  ? 887  LYS A C   1 
ATOM   4708 O  O   . LYS A 1 624 ? -20.491 -75.769 -23.490 1.00 51.95  ? 887  LYS A O   1 
ATOM   4709 C  CB  . LYS A 1 624 ? -18.630 -73.739 -25.471 1.00 60.63  ? 887  LYS A CB  1 
ATOM   4710 C  CG  . LYS A 1 624 ? -18.296 -75.056 -26.175 1.00 72.35  ? 887  LYS A CG  1 
ATOM   4711 C  CD  . LYS A 1 624 ? -17.447 -74.909 -27.442 1.00 76.48  ? 887  LYS A CD  1 
ATOM   4712 C  CE  . LYS A 1 624 ? -15.956 -75.058 -27.204 1.00 81.43  ? 887  LYS A CE  1 
ATOM   4713 N  NZ  . LYS A 1 624 ? -15.410 -73.966 -26.362 1.00 79.91  ? 887  LYS A NZ  1 
ATOM   4714 N  N   . ARG A 1 625 ? -19.136 -74.284 -22.411 0.36 52.85  ? 888  ARG A N   1 
ATOM   4715 C  CA  . ARG A 1 625 ? -18.778 -75.160 -21.258 0.36 51.89  ? 888  ARG A CA  1 
ATOM   4716 C  C   . ARG A 1 625 ? -20.025 -75.528 -20.440 0.36 50.71  ? 888  ARG A C   1 
ATOM   4717 O  O   . ARG A 1 625 ? -20.003 -76.604 -19.820 0.36 50.11  ? 888  ARG A O   1 
ATOM   4718 C  CB  . ARG A 1 625 ? -17.714 -74.505 -20.368 0.36 52.38  ? 888  ARG A CB  1 
ATOM   4719 C  CG  . ARG A 1 625 ? -18.187 -73.299 -19.568 0.36 52.45  ? 888  ARG A CG  1 
ATOM   4720 C  CD  . ARG A 1 625 ? -17.128 -72.857 -18.574 0.36 52.54  ? 888  ARG A CD  1 
ATOM   4721 N  NE  . ARG A 1 625 ? -16.956 -73.822 -17.493 0.36 52.92  ? 888  ARG A NE  1 
ATOM   4722 C  CZ  . ARG A 1 625 ? -15.883 -73.925 -16.707 0.36 51.98  ? 888  ARG A CZ  1 
ATOM   4723 N  NH1 . ARG A 1 625 ? -14.844 -73.118 -16.863 0.36 53.97  ? 888  ARG A NH1 1 
ATOM   4724 N  NH2 . ARG A 1 625 ? -15.852 -74.848 -15.762 0.36 51.04  ? 888  ARG A NH2 1 
ATOM   4725 N  N   . PHE A 1 626 ? -21.060 -74.677 -20.427 1.00 50.11  ? 889  PHE A N   1 
ATOM   4726 C  CA  . PHE A 1 626 ? -22.307 -74.921 -19.631 1.00 49.91  ? 889  PHE A CA  1 
ATOM   4727 C  C   . PHE A 1 626 ? -23.374 -75.515 -20.562 1.00 56.75  ? 889  PHE A C   1 
ATOM   4728 O  O   . PHE A 1 626 ? -24.452 -75.934 -20.090 1.00 58.70  ? 889  PHE A O   1 
ATOM   4729 C  CB  . PHE A 1 626 ? -22.771 -73.657 -18.888 1.00 46.89  ? 889  PHE A CB  1 
ATOM   4730 C  CG  . PHE A 1 626 ? -21.716 -73.036 -17.995 1.00 47.45  ? 889  PHE A CG  1 
ATOM   4731 C  CD1 . PHE A 1 626 ? -21.269 -73.681 -16.842 1.00 47.12  ? 889  PHE A CD1 1 
ATOM   4732 C  CD2 . PHE A 1 626 ? -21.138 -71.821 -18.326 1.00 40.39  ? 889  PHE A CD2 1 
ATOM   4733 C  CE1 . PHE A 1 626 ? -20.270 -73.126 -16.047 1.00 50.60  ? 889  PHE A CE1 1 
ATOM   4734 C  CE2 . PHE A 1 626 ? -20.141 -71.262 -17.529 1.00 44.01  ? 889  PHE A CE2 1 
ATOM   4735 C  CZ  . PHE A 1 626 ? -19.704 -71.907 -16.384 1.00 40.95  ? 889  PHE A CZ  1 
ATOM   4736 N  N   . ARG A 1 627 ? -23.091 -75.540 -21.863 1.00 64.35  ? 890  ARG A N   1 
ATOM   4737 C  CA  . ARG A 1 627 ? -23.956 -76.181 -22.885 1.00 79.92  ? 890  ARG A CA  1 
ATOM   4738 C  C   . ARG A 1 627 ? -23.614 -77.679 -22.907 1.00 91.95  ? 890  ARG A C   1 
ATOM   4739 O  O   . ARG A 1 627 ? -22.907 -78.104 -23.845 1.00 106.76 ? 890  ARG A O   1 
ATOM   4740 C  CB  . ARG A 1 627 ? -23.756 -75.459 -24.224 1.00 80.09  ? 890  ARG A CB  1 
ATOM   4741 C  CG  . ARG A 1 627 ? -24.754 -75.845 -25.305 1.00 80.70  ? 890  ARG A CG  1 
ATOM   4742 C  CD  . ARG A 1 627 ? -24.500 -75.114 -26.609 1.00 81.57  ? 890  ARG A CD  1 
ATOM   4743 N  NE  . ARG A 1 627 ? -23.120 -75.229 -27.062 1.00 82.51  ? 890  ARG A NE  1 
ATOM   4744 C  CZ  . ARG A 1 627 ? -22.585 -76.279 -27.684 1.00 84.60  ? 890  ARG A CZ  1 
ATOM   4745 N  NH1 . ARG A 1 627 ? -23.308 -77.358 -27.943 1.00 89.97  ? 890  ARG A NH1 1 
ATOM   4746 N  NH2 . ARG A 1 627 ? -21.316 -76.246 -28.051 1.00 83.60  ? 890  ARG A NH2 1 
ATOM   4747 N  N   . ARG A 1 628 ? -24.043 -78.424 -21.874 1.00 101.10 ? 891  ARG A N   1 
ATOM   4748 C  CA  . ARG A 1 628 ? -23.934 -79.909 -21.751 1.00 105.08 ? 891  ARG A CA  1 
ATOM   4749 C  C   . ARG A 1 628 ? -22.484 -80.380 -21.935 1.00 95.83  ? 891  ARG A C   1 
ATOM   4750 O  O   . ARG A 1 628 ? -21.518 -79.648 -21.745 1.00 87.69  ? 891  ARG A O   1 
ATOM   4751 C  CB  . ARG A 1 628 ? -24.835 -80.587 -22.789 1.00 109.96 ? 891  ARG A CB  1 
ATOM   4752 C  CG  . ARG A 1 628 ? -26.321 -80.308 -22.608 1.00 110.71 ? 891  ARG A CG  1 
ATOM   4753 C  CD  . ARG A 1 628 ? -26.798 -80.603 -21.199 1.00 113.20 ? 891  ARG A CD  1 
ATOM   4754 N  NE  . ARG A 1 628 ? -26.324 -81.900 -20.727 1.00 115.72 ? 891  ARG A NE  1 
ATOM   4755 C  CZ  . ARG A 1 628 ? -26.429 -82.347 -19.479 1.00 116.10 ? 891  ARG A CZ  1 
ATOM   4756 N  NH1 . ARG A 1 628 ? -26.995 -81.606 -18.542 1.00 116.92 ? 891  ARG A NH1 1 
ATOM   4757 N  NH2 . ARG A 1 628 ? -25.965 -83.545 -19.169 1.00 120.47 ? 891  ARG A NH2 1 
HETATM 4758 ZN ZN  . ZN  B 2 .   ? -6.535  -55.440 -23.802 1.00 18.48  2 1001 ZN  A ZN  1 
HETATM 4759 ZN ZN  . ZN  C 2 .   ? -25.930 -14.633 -13.369 1.00 47.56  2 1002 ZN  A ZN  1 
HETATM 4760 O  O1  A MES D 3 .   ? -28.412 -57.945 0.659   0.25 24.71  ? 1003 MES A O1  1 
HETATM 4761 O  O1  B MES D 3 .   ? -27.967 -57.541 0.216   0.25 492.77 ? 1003 MES A O1  1 
HETATM 4762 C  C2  A MES D 3 .   ? -27.707 -58.270 1.844   0.25 23.79  ? 1003 MES A C2  1 
HETATM 4763 C  C2  B MES D 3 .   ? -27.275 -58.030 1.355   0.25 499.29 ? 1003 MES A C2  1 
HETATM 4764 C  C3  A MES D 3 .   ? -26.314 -57.706 1.799   0.25 23.19  ? 1003 MES A C3  1 
HETATM 4765 C  C3  B MES D 3 .   ? -25.784 -58.027 1.133   0.25 500.29 ? 1003 MES A C3  1 
HETATM 4766 N  N4  A MES D 3 .   ? -25.580 -58.284 0.638   0.25 21.29  ? 1003 MES A N4  1 
HETATM 4767 N  N4  B MES D 3 .   ? -25.448 -58.874 -0.052  0.25 497.20 ? 1003 MES A N4  1 
HETATM 4768 C  C5  A MES D 3 .   ? -26.340 -58.045 -0.624  0.25 22.91  ? 1003 MES A C5  1 
HETATM 4769 C  C5  B MES D 3 .   ? -26.216 -58.371 -1.232  0.25 488.38 ? 1003 MES A C5  1 
HETATM 4770 C  C6  A MES D 3 .   ? -27.773 -58.512 -0.480  0.25 24.86  ? 1003 MES A C6  1 
HETATM 4771 C  C6  B MES D 3 .   ? -27.689 -58.356 -0.912  0.25 483.60 ? 1003 MES A C6  1 
HETATM 4772 C  C7  A MES D 3 .   ? -24.174 -57.769 0.557   0.25 20.88  ? 1003 MES A C7  1 
HETATM 4773 C  C7  B MES D 3 .   ? -23.972 -58.916 -0.325  0.25 501.20 ? 1003 MES A C7  1 
HETATM 4774 C  C8  A MES D 3 .   ? -23.312 -58.697 -0.261  0.25 20.88  ? 1003 MES A C8  1 
HETATM 4775 C  C8  B MES D 3 .   ? -23.189 -57.850 0.416   0.25 507.25 ? 1003 MES A C8  1 
HETATM 4776 S  S   A MES D 3 .   ? -21.584 -58.648 0.165   0.25 18.79  ? 1003 MES A S   1 
HETATM 4777 S  S   B MES D 3 .   ? -21.438 -58.166 0.403   0.25 513.68 ? 1003 MES A S   1 
HETATM 4778 O  O1S A MES D 3 .   ? -21.308 -59.966 0.607   0.25 23.17  ? 1003 MES A O1S 1 
HETATM 4779 O  O1S B MES D 3 .   ? -21.292 -59.594 0.439   0.25 515.89 ? 1003 MES A O1S 1 
HETATM 4780 O  O2S A MES D 3 .   ? -20.939 -58.298 -1.073  0.25 19.63  ? 1003 MES A O2S 1 
HETATM 4781 O  O2S B MES D 3 .   ? -20.939 -57.591 -0.814  0.25 496.64 ? 1003 MES A O2S 1 
HETATM 4782 O  O3S A MES D 3 .   ? -21.369 -57.667 1.188   0.25 22.87  ? 1003 MES A O3S 1 
HETATM 4783 O  O3S B MES D 3 .   ? -20.909 -57.527 1.574   0.25 512.14 ? 1003 MES A O3S 1 
HETATM 4784 S  S   . DMS E 4 .   ? -26.976 -62.120 -20.959 1.00 38.66  ? 1004 DMS A S   1 
HETATM 4785 O  O   . DMS E 4 .   ? -26.707 -62.787 -22.388 1.00 41.82  ? 1004 DMS A O   1 
HETATM 4786 C  C1  . DMS E 4 .   ? -28.156 -60.866 -21.207 1.00 36.04  ? 1004 DMS A C1  1 
HETATM 4787 C  C2  . DMS E 4 .   ? -25.520 -61.090 -20.788 1.00 40.64  ? 1004 DMS A C2  1 
HETATM 4788 S  S   . DMS F 4 .   ? -16.087 -69.459 -28.943 1.00 96.65  ? 1005 DMS A S   1 
HETATM 4789 O  O   . DMS F 4 .   ? -16.461 -68.014 -29.193 1.00 63.14  ? 1005 DMS A O   1 
HETATM 4790 C  C1  . DMS F 4 .   ? -17.065 -70.009 -27.558 1.00 78.13  ? 1005 DMS A C1  1 
HETATM 4791 C  C2  . DMS F 4 .   ? -14.491 -69.450 -28.153 1.00 86.08  ? 1005 DMS A C2  1 
HETATM 4792 S  S   . DMS G 4 .   ? -23.178 -48.287 -16.226 1.00 51.48  ? 1006 DMS A S   1 
HETATM 4793 O  O   . DMS G 4 .   ? -24.212 -47.992 -17.287 1.00 46.11  ? 1006 DMS A O   1 
HETATM 4794 C  C1  . DMS G 4 .   ? -21.736 -47.435 -16.767 1.00 54.02  ? 1006 DMS A C1  1 
HETATM 4795 C  C2  . DMS G 4 .   ? -22.598 -49.871 -16.602 1.00 43.40  ? 1006 DMS A C2  1 
HETATM 4796 C  C1  . PEG H 5 .   ? -30.669 -47.670 -25.193 1.00 68.87  ? 1007 PEG A C1  1 
HETATM 4797 O  O1  . PEG H 5 .   ? -30.320 -47.544 -26.565 1.00 65.90  ? 1007 PEG A O1  1 
HETATM 4798 C  C2  . PEG H 5 .   ? -30.797 -46.346 -24.499 1.00 72.65  ? 1007 PEG A C2  1 
HETATM 4799 O  O2  . PEG H 5 .   ? -31.198 -46.549 -23.145 1.00 75.09  ? 1007 PEG A O2  1 
HETATM 4800 C  C3  . PEG H 5 .   ? -31.556 -45.353 -22.452 1.00 85.09  ? 1007 PEG A C3  1 
HETATM 4801 C  C4  . PEG H 5 .   ? -30.326 -44.682 -21.906 1.00 84.46  ? 1007 PEG A C4  1 
HETATM 4802 O  O4  . PEG H 5 .   ? -30.380 -44.470 -20.506 1.00 80.41  ? 1007 PEG A O4  1 
HETATM 4803 P  P   . PO4 I 6 .   ? -4.242  -39.539 -23.999 1.00 42.50  ? 1008 PO4 A P   1 
HETATM 4804 O  O1  . PO4 I 6 .   ? -2.835  -40.313 -23.412 1.00 32.26  ? 1008 PO4 A O1  1 
HETATM 4805 O  O2  . PO4 I 6 .   ? -3.768  -38.035 -24.727 1.00 30.00  ? 1008 PO4 A O2  1 
HETATM 4806 O  O3  . PO4 I 6 .   ? -4.916  -40.414 -25.271 1.00 32.84  ? 1008 PO4 A O3  1 
HETATM 4807 O  O4  . PO4 I 6 .   ? -5.229  -39.337 -22.877 1.00 60.63  ? 1008 PO4 A O4  1 
HETATM 4808 P  P   . PO4 J 6 .   ? -18.332 -9.685  -29.325 1.00 105.54 ? 1009 PO4 A P   1 
HETATM 4809 O  O1  . PO4 J 6 .   ? -17.870 -10.040 -27.883 1.00 69.00  ? 1009 PO4 A O1  1 
HETATM 4810 O  O2  . PO4 J 6 .   ? -17.085 -9.462  -30.191 1.00 89.29  ? 1009 PO4 A O2  1 
HETATM 4811 O  O3  . PO4 J 6 .   ? -19.180 -10.867 -29.911 1.00 70.46  ? 1009 PO4 A O3  1 
HETATM 4812 O  O4  . PO4 J 6 .   ? -19.188 -8.370  -29.327 1.00 72.92  ? 1009 PO4 A O4  1 
HETATM 4813 C  C1  . PEG K 5 .   ? -16.283 -43.871 -41.209 1.00 66.14  ? 1010 PEG A C1  1 
HETATM 4814 O  O1  . PEG K 5 .   ? -17.655 -44.165 -41.068 1.00 62.42  ? 1010 PEG A O1  1 
HETATM 4815 C  C2  . PEG K 5 .   ? -15.697 -44.565 -42.379 1.00 69.72  ? 1010 PEG A C2  1 
HETATM 4816 O  O2  . PEG K 5 .   ? -16.351 -45.819 -42.550 1.00 73.53  ? 1010 PEG A O2  1 
HETATM 4817 C  C3  . PEG K 5 .   ? -16.273 -46.324 -43.880 1.00 72.22  ? 1010 PEG A C3  1 
HETATM 4818 C  C4  . PEG K 5 .   ? -15.170 -47.323 -43.987 1.00 74.08  ? 1010 PEG A C4  1 
HETATM 4819 O  O4  . PEG K 5 .   ? -15.625 -48.553 -44.518 1.00 71.08  ? 1010 PEG A O4  1 
HETATM 4820 N  N1  . NW4 L 7 .   ? -6.444  -74.678 -15.499 0.36 46.89  ? 1011 NW4 A N1  1 
HETATM 4821 C  C4  . NW4 L 7 .   ? -8.306  -72.292 -19.391 0.36 47.82  ? 1011 NW4 A C4  1 
HETATM 4822 C  C5  . NW4 L 7 .   ? -7.960  -71.188 -20.383 0.36 47.72  ? 1011 NW4 A C5  1 
HETATM 4823 C  C6  . NW4 L 7 .   ? -9.110  -70.881 -21.335 0.36 47.77  ? 1011 NW4 A C6  1 
HETATM 4824 C  C7  . NW4 L 7 .   ? -10.367 -70.520 -20.573 0.36 46.96  ? 1011 NW4 A C7  1 
HETATM 4825 C  C8  . NW4 L 7 .   ? -10.737 -71.624 -19.604 0.36 47.67  ? 1011 NW4 A C8  1 
HETATM 4826 C  C10 . NW4 L 7 .   ? -5.639  -74.362 -14.310 0.36 46.68  ? 1011 NW4 A C10 1 
HETATM 4827 C  C13 . NW4 L 7 .   ? -7.555  -75.621 -15.312 0.36 46.90  ? 1011 NW4 A C13 1 
HETATM 4828 C  C1  . NW4 L 7 .   ? -6.191  -74.107 -16.696 0.36 46.25  ? 1011 NW4 A C1  1 
HETATM 4829 C  C11 . NW4 L 7 .   ? -6.522  -74.209 -13.103 0.36 46.35  ? 1011 NW4 A C11 1 
HETATM 4830 C  C12 . NW4 L 7 .   ? -8.259  -75.352 -14.011 0.36 46.01  ? 1011 NW4 A C12 1 
HETATM 4831 C  C2  . NW4 L 7 .   ? -7.369  -73.805 -17.592 0.36 47.65  ? 1011 NW4 A C2  1 
HETATM 4832 C  C3  . NW4 L 7 .   ? -7.156  -72.538 -18.416 0.36 47.75  ? 1011 NW4 A C3  1 
HETATM 4833 C  C9  . NW4 L 7 .   ? -9.588  -71.929 -18.652 0.36 48.14  ? 1011 NW4 A C9  1 
HETATM 4834 O  O1  . NW4 L 7 .   ? -5.060  -73.810 -17.043 0.36 44.91  ? 1011 NW4 A O1  1 
HETATM 4835 O  O2  . NW4 L 7 .   ? -7.348  -75.335 -12.938 0.36 45.58  ? 1011 NW4 A O2  1 
HETATM 4836 CL CL  . CL  M 8 .   ? 4.121   -49.067 -29.855 1.00 36.04  ? 1012 CL  A CL  1 
HETATM 4837 O  O   . HOH N 9 .   ? -13.713 -49.228 -29.856 0.50 27.11  ? 1101 HOH A O   1 
HETATM 4838 O  O   . HOH N 9 .   ? 2.904   -51.554 -26.951 1.00 30.81  ? 1102 HOH A O   1 
HETATM 4839 O  O   . HOH N 9 .   ? -13.119 -22.046 -41.655 1.00 42.20  ? 1103 HOH A O   1 
HETATM 4840 O  O   . HOH N 9 .   ? -34.841 -20.818 -23.997 1.00 49.01  ? 1104 HOH A O   1 
HETATM 4841 O  O   . HOH N 9 .   ? -7.503  -49.222 0.724   1.00 50.95  ? 1105 HOH A O   1 
HETATM 4842 O  O   . HOH N 9 .   ? -36.002 -57.560 -30.811 1.00 54.34  ? 1106 HOH A O   1 
HETATM 4843 O  O   . HOH N 9 .   ? -29.337 -56.164 -36.358 1.00 49.34  ? 1107 HOH A O   1 
HETATM 4844 O  O   . HOH N 9 .   ? -19.915 -9.795  -33.163 1.00 41.99  ? 1108 HOH A O   1 
HETATM 4845 O  O   . HOH N 9 .   ? -5.306  -58.606 -29.868 1.00 36.51  ? 1109 HOH A O   1 
HETATM 4846 O  O   . HOH N 9 .   ? -3.928  -37.979 -45.571 1.00 58.70  ? 1110 HOH A O   1 
HETATM 4847 O  O   . HOH N 9 .   ? -13.689 -45.204 -3.704  1.00 53.05  ? 1111 HOH A O   1 
HETATM 4848 O  O   . HOH N 9 .   ? 5.890   -45.100 -35.975 1.00 42.16  ? 1112 HOH A O   1 
HETATM 4849 O  O   . HOH N 9 .   ? -20.030 -66.313 -37.551 1.00 56.14  ? 1113 HOH A O   1 
HETATM 4850 O  O   . HOH N 9 .   ? -15.436 -22.128 -19.173 1.00 42.47  ? 1114 HOH A O   1 
HETATM 4851 O  O   . HOH N 9 .   ? -33.720 -47.774 -4.362  1.00 30.02  ? 1115 HOH A O   1 
HETATM 4852 O  O   . HOH N 9 .   ? -32.097 -70.977 -8.835  1.00 43.77  ? 1116 HOH A O   1 
HETATM 4853 O  O   . HOH N 9 .   ? -27.266 -65.743 -39.896 1.00 38.76  ? 1117 HOH A O   1 
HETATM 4854 O  O   . HOH N 9 .   ? -11.878 -47.472 -43.235 1.00 54.16  ? 1118 HOH A O   1 
HETATM 4855 O  O   . HOH N 9 .   ? -22.607 -53.753 -46.677 1.00 44.55  ? 1119 HOH A O   1 
HETATM 4856 O  O   . HOH N 9 .   ? -17.684 -32.043 -42.314 0.50 36.01  ? 1120 HOH A O   1 
HETATM 4857 O  O   . HOH N 9 .   ? -14.956 -71.031 -18.224 0.36 23.08  ? 1121 HOH A O   1 
HETATM 4858 O  O   . HOH N 9 .   ? -25.178 -21.061 -8.063  1.00 57.73  ? 1122 HOH A O   1 
HETATM 4859 O  O   . HOH N 9 .   ? -42.314 -63.254 -5.155  1.00 43.80  ? 1123 HOH A O   1 
HETATM 4860 O  O   . HOH N 9 .   ? -6.915  -61.162 -30.353 1.00 55.25  ? 1124 HOH A O   1 
HETATM 4861 O  O   . HOH N 9 .   ? -13.449 -13.040 -27.530 1.00 41.68  ? 1125 HOH A O   1 
HETATM 4862 O  O   . HOH N 9 .   ? -21.967 -10.117 -9.603  1.00 54.07  ? 1126 HOH A O   1 
HETATM 4863 O  O   . HOH N 9 .   ? -30.060 -50.615 -27.052 1.00 37.74  ? 1127 HOH A O   1 
HETATM 4864 O  O   . HOH N 9 .   ? -7.106  -20.445 -27.314 1.00 35.84  ? 1128 HOH A O   1 
HETATM 4865 O  O   . HOH N 9 .   ? -32.474 -60.670 -18.868 1.00 36.87  ? 1129 HOH A O   1 
HETATM 4866 O  O   . HOH N 9 .   ? -19.704 -27.601 -40.247 1.00 29.85  ? 1130 HOH A O   1 
HETATM 4867 O  O   . HOH N 9 .   ? -6.132  -12.454 -22.310 1.00 63.00  ? 1131 HOH A O   1 
HETATM 4868 O  O   . HOH N 9 .   ? -4.312  -54.502 -11.874 1.00 45.28  ? 1132 HOH A O   1 
HETATM 4869 O  O   . HOH N 9 .   ? -21.456 -41.736 -35.415 1.00 54.10  ? 1133 HOH A O   1 
HETATM 4870 O  O   . HOH N 9 .   ? -15.290 -54.686 -39.595 1.00 38.11  ? 1134 HOH A O   1 
HETATM 4871 O  O   . HOH N 9 .   ? -2.732  -49.193 -39.845 1.00 47.55  ? 1135 HOH A O   1 
HETATM 4872 O  O   . HOH N 9 .   ? -28.642 -69.879 -14.086 1.00 38.45  ? 1136 HOH A O   1 
HETATM 4873 O  O   . HOH N 9 .   ? -8.007  -43.053 -42.991 1.00 44.41  ? 1137 HOH A O   1 
HETATM 4874 O  O   . HOH N 9 .   ? -4.040  -57.478 -9.842  1.00 27.39  ? 1138 HOH A O   1 
HETATM 4875 O  O   . HOH N 9 .   ? -16.528 -11.933 -29.666 1.00 46.91  ? 1139 HOH A O   1 
HETATM 4876 O  O   . HOH N 9 .   ? -23.224 -65.257 -38.851 1.00 40.66  ? 1140 HOH A O   1 
HETATM 4877 O  O   . HOH N 9 .   ? -28.186 -18.509 -35.208 1.00 49.42  ? 1141 HOH A O   1 
HETATM 4878 O  O   . HOH N 9 .   ? 5.576   -20.104 -43.357 1.00 50.49  ? 1142 HOH A O   1 
HETATM 4879 O  O   . HOH N 9 .   ? -39.932 -64.110 -19.743 1.00 54.77  ? 1143 HOH A O   1 
HETATM 4880 O  O   . HOH N 9 .   ? -23.625 -46.534 -36.852 1.00 51.66  ? 1144 HOH A O   1 
HETATM 4881 O  O   . HOH N 9 .   ? -4.319  -65.487 -15.217 1.00 29.93  ? 1145 HOH A O   1 
HETATM 4882 O  O   . HOH N 9 .   ? -20.707 -47.399 -10.079 1.00 46.62  ? 1146 HOH A O   1 
HETATM 4883 O  O   . HOH N 9 .   ? 5.144   -23.623 -20.142 1.00 70.25  ? 1147 HOH A O   1 
HETATM 4884 O  O   . HOH N 9 .   ? -29.698 -33.726 -28.863 1.00 55.15  ? 1148 HOH A O   1 
HETATM 4885 O  O   . HOH N 9 .   ? -4.380  -53.841 -28.070 1.00 22.76  ? 1149 HOH A O   1 
HETATM 4886 O  O   . HOH N 9 .   ? 0.122   -33.047 -28.101 1.00 24.90  ? 1150 HOH A O   1 
HETATM 4887 O  O   . HOH N 9 .   ? -8.863  -64.264 -30.917 1.00 40.38  ? 1151 HOH A O   1 
HETATM 4888 O  O   . HOH N 9 .   ? -24.084 -69.767 -27.685 1.00 39.00  ? 1152 HOH A O   1 
HETATM 4889 O  O   . HOH N 9 .   ? -38.299 -67.887 -8.326  1.00 34.52  ? 1153 HOH A O   1 
HETATM 4890 O  O   . HOH N 9 .   ? -20.098 -38.598 -26.106 1.00 52.87  ? 1154 HOH A O   1 
HETATM 4891 O  O   . HOH N 9 .   ? -16.317 -66.860 -20.674 0.36 45.50  ? 1155 HOH A O   1 
HETATM 4892 O  O   . HOH N 9 .   ? 10.082  -25.765 -32.653 1.00 46.22  ? 1156 HOH A O   1 
HETATM 4893 O  O   . HOH N 9 .   ? -40.277 -61.377 -11.339 1.00 25.15  ? 1157 HOH A O   1 
HETATM 4894 O  O   . HOH N 9 .   ? -0.035  -31.300 -23.311 1.00 27.61  ? 1158 HOH A O   1 
HETATM 4895 O  O   . HOH N 9 .   ? 6.529   -35.241 -44.100 1.00 45.24  ? 1159 HOH A O   1 
HETATM 4896 O  O   . HOH N 9 .   ? -31.834 -57.501 -21.625 1.00 28.14  ? 1160 HOH A O   1 
HETATM 4897 O  O   . HOH N 9 .   ? -5.132  -15.683 -28.516 1.00 43.13  ? 1161 HOH A O   1 
HETATM 4898 O  O   . HOH N 9 .   ? -41.821 -58.833 -6.249  1.00 39.79  ? 1162 HOH A O   1 
HETATM 4899 O  O   . HOH N 9 .   ? -22.693 -66.024 -23.735 1.00 34.69  ? 1163 HOH A O   1 
HETATM 4900 O  O   . HOH N 9 .   ? -28.775 -63.174 -25.325 1.00 31.58  ? 1164 HOH A O   1 
HETATM 4901 O  O   . HOH N 9 .   ? -26.701 -25.675 -33.462 1.00 29.03  ? 1165 HOH A O   1 
HETATM 4902 O  O   . HOH N 9 .   ? 6.549   -39.482 -24.075 0.50 51.96  ? 1166 HOH A O   1 
HETATM 4903 O  O   . HOH N 9 .   ? -13.101 -53.665 -40.736 1.00 48.31  ? 1167 HOH A O   1 
HETATM 4904 O  O   . HOH N 9 .   ? -28.471 -50.089 0.168   1.00 26.27  ? 1168 HOH A O   1 
HETATM 4905 O  O   . HOH N 9 .   ? 1.330   -32.589 -38.995 1.00 25.13  ? 1169 HOH A O   1 
HETATM 4906 O  O   . HOH N 9 .   ? 10.479  -38.728 -29.915 1.00 46.44  ? 1170 HOH A O   1 
HETATM 4907 O  O   . HOH N 9 .   ? 7.741   -43.042 -36.457 1.00 45.73  ? 1171 HOH A O   1 
HETATM 4908 O  O   . HOH N 9 .   ? -14.662 -64.200 -0.507  1.00 22.22  ? 1172 HOH A O   1 
HETATM 4909 O  O   . HOH N 9 .   ? -17.947 -62.320 -2.980  1.00 19.11  ? 1173 HOH A O   1 
HETATM 4910 O  O   . HOH N 9 .   ? -3.963  -15.475 -20.949 1.00 47.37  ? 1174 HOH A O   1 
HETATM 4911 O  O   . HOH N 9 .   ? -27.435 -9.200  -30.443 1.00 53.26  ? 1175 HOH A O   1 
HETATM 4912 O  O   . HOH N 9 .   ? -3.362  -20.299 -23.704 1.00 33.47  ? 1176 HOH A O   1 
HETATM 4913 O  O   . HOH N 9 .   ? -21.551 -49.645 -34.991 1.00 41.27  ? 1177 HOH A O   1 
HETATM 4914 O  O   . HOH N 9 .   ? -36.881 -50.453 -5.368  1.00 32.95  ? 1178 HOH A O   1 
HETATM 4915 O  O   . HOH N 9 .   ? -21.887 -66.234 -4.502  1.00 30.35  ? 1179 HOH A O   1 
HETATM 4916 O  O   . HOH N 9 .   ? -38.872 -57.354 -20.359 1.00 38.50  ? 1180 HOH A O   1 
HETATM 4917 O  O   . HOH N 9 .   ? -20.744 -29.147 -25.125 1.00 37.19  ? 1181 HOH A O   1 
HETATM 4918 O  O   . HOH N 9 .   ? -28.634 -68.134 -29.993 1.00 52.94  ? 1182 HOH A O   1 
HETATM 4919 O  O   . HOH N 9 .   ? -19.369 -20.826 -40.728 1.00 37.71  ? 1183 HOH A O   1 
HETATM 4920 O  O   . HOH N 9 .   ? -35.528 -66.763 -0.671  1.00 33.01  ? 1184 HOH A O   1 
HETATM 4921 O  O   . HOH N 9 .   ? -35.150 -50.418 -12.796 1.00 35.48  ? 1185 HOH A O   1 
HETATM 4922 O  O   . HOH N 9 .   ? -8.319  -76.016 -10.512 1.00 49.75  ? 1186 HOH A O   1 
HETATM 4923 O  O   . HOH N 9 .   ? 2.623   -39.670 -27.160 1.00 29.78  ? 1187 HOH A O   1 
HETATM 4924 O  O   . HOH N 9 .   ? -16.585 -32.345 -18.506 1.00 42.57  ? 1188 HOH A O   1 
HETATM 4925 O  O   . HOH N 9 .   ? -1.572  -41.655 -21.437 1.00 53.14  ? 1189 HOH A O   1 
HETATM 4926 O  O   . HOH N 9 .   ? -5.775  -59.266 -12.289 1.00 36.22  ? 1190 HOH A O   1 
HETATM 4927 O  O   . HOH N 9 .   ? -14.996 -17.422 -36.401 1.00 38.99  ? 1191 HOH A O   1 
HETATM 4928 O  O   . HOH N 9 .   ? -38.763 -60.953 -4.233  1.00 30.78  ? 1192 HOH A O   1 
HETATM 4929 O  O   . HOH N 9 .   ? -32.729 -52.040 -27.252 1.00 37.52  ? 1193 HOH A O   1 
HETATM 4930 O  O   . HOH N 9 .   ? 3.888   -28.955 -44.570 1.00 36.73  ? 1194 HOH A O   1 
HETATM 4931 O  O   . HOH N 9 .   ? -27.471 -52.578 -42.030 1.00 45.79  ? 1195 HOH A O   1 
HETATM 4932 O  O   . HOH N 9 .   ? -32.753 -63.681 -15.131 1.00 23.72  ? 1196 HOH A O   1 
HETATM 4933 O  O   . HOH N 9 .   ? -29.185 -17.794 -21.016 1.00 47.08  ? 1197 HOH A O   1 
HETATM 4934 O  O   . HOH N 9 .   ? -7.343  -47.422 -18.216 1.00 29.06  ? 1198 HOH A O   1 
HETATM 4935 O  O   . HOH N 9 .   ? -9.017  -59.182 -13.329 1.00 21.29  ? 1199 HOH A O   1 
HETATM 4936 O  O   . HOH N 9 .   ? 0.490   -23.668 -17.177 1.00 50.42  ? 1200 HOH A O   1 
HETATM 4937 O  O   . HOH N 9 .   ? -3.733  -61.637 -15.469 1.00 25.00  ? 1201 HOH A O   1 
HETATM 4938 O  O   . HOH N 9 .   ? 2.736   -44.362 -40.991 0.50 37.11  ? 1202 HOH A O   1 
HETATM 4939 O  O   . HOH N 9 .   ? -11.515 -12.091 -9.538  1.00 58.53  ? 1203 HOH A O   1 
HETATM 4940 O  O   . HOH N 9 .   ? -3.635  -55.497 -35.790 1.00 57.14  ? 1204 HOH A O   1 
HETATM 4941 O  O   . HOH N 9 .   ? 5.707   -32.930 -37.983 1.00 36.78  ? 1205 HOH A O   1 
HETATM 4942 O  O   . HOH N 9 .   ? -9.813  -64.717 -33.138 1.00 47.75  ? 1206 HOH A O   1 
HETATM 4943 O  O   . HOH N 9 .   ? -10.914 -62.492 -18.773 1.00 17.16  ? 1207 HOH A O   1 
HETATM 4944 O  O   . HOH N 9 .   ? 10.835  -40.903 -37.831 1.00 50.46  ? 1208 HOH A O   1 
HETATM 4945 O  O   . HOH N 9 .   ? 5.514   -30.222 -21.923 1.00 29.88  ? 1209 HOH A O   1 
HETATM 4946 O  O   . HOH N 9 .   ? -15.069 -34.967 -29.164 1.00 20.87  ? 1210 HOH A O   1 
HETATM 4947 O  O   . HOH N 9 .   ? -2.539  -55.710 -31.351 1.00 41.16  ? 1211 HOH A O   1 
HETATM 4948 O  O   . HOH N 9 .   ? -24.491 -69.897 -34.223 1.00 52.92  ? 1212 HOH A O   1 
HETATM 4949 O  O   . HOH N 9 .   ? -0.801  -11.234 -30.443 1.00 47.67  ? 1213 HOH A O   1 
HETATM 4950 O  O   . HOH N 9 .   ? -30.357 -57.156 -34.284 1.00 31.51  ? 1214 HOH A O   1 
HETATM 4951 O  O   . HOH N 9 .   ? -17.639 -62.255 -44.867 1.00 51.99  ? 1215 HOH A O   1 
HETATM 4952 O  O   . HOH N 9 .   ? 7.689   -22.120 -24.907 1.00 38.15  ? 1216 HOH A O   1 
HETATM 4953 O  O   . HOH N 9 .   ? -2.575  -58.190 -27.459 1.00 22.69  ? 1217 HOH A O   1 
HETATM 4954 O  O   . HOH N 9 .   ? -9.504  -21.542 -27.332 1.00 31.51  ? 1218 HOH A O   1 
HETATM 4955 O  O   . HOH N 9 .   ? -4.672  -62.615 -4.636  1.00 35.08  ? 1219 HOH A O   1 
HETATM 4956 O  O   . HOH N 9 .   ? -31.095 -73.984 -18.002 1.00 53.15  ? 1220 HOH A O   1 
HETATM 4957 O  O   . HOH N 9 .   ? -11.072 -48.491 -39.216 1.00 25.20  ? 1221 HOH A O   1 
HETATM 4958 O  O   . HOH N 9 .   ? -34.646 -63.069 -28.704 1.00 72.63  ? 1222 HOH A O   1 
HETATM 4959 O  O   . HOH N 9 .   ? -32.487 -49.061 -18.939 1.00 41.36  ? 1223 HOH A O   1 
HETATM 4960 O  O   . HOH N 9 .   ? -18.206 -76.204 -16.198 1.00 51.47  ? 1224 HOH A O   1 
HETATM 4961 O  O   . HOH N 9 .   ? -12.914 -42.863 -38.953 1.00 34.33  ? 1225 HOH A O   1 
HETATM 4962 O  O   . HOH N 9 .   ? -42.466 -63.434 -18.684 1.00 54.59  ? 1226 HOH A O   1 
HETATM 4963 O  O   . HOH N 9 .   ? -29.445 -63.677 -34.339 1.00 50.69  ? 1227 HOH A O   1 
HETATM 4964 O  O   . HOH N 9 .   ? -8.321  -64.951 -7.023  1.00 26.01  ? 1228 HOH A O   1 
HETATM 4965 O  O   . HOH N 9 .   ? -0.197  -55.484 -33.068 1.00 59.37  ? 1229 HOH A O   1 
HETATM 4966 O  O   . HOH N 9 .   ? -42.618 -61.993 -14.799 1.00 32.66  ? 1230 HOH A O   1 
HETATM 4967 O  O   . HOH N 9 .   ? -15.049 -20.174 -21.927 1.00 47.41  ? 1231 HOH A O   1 
HETATM 4968 O  O   . HOH N 9 .   ? 7.238   -49.832 -30.721 1.00 49.70  ? 1232 HOH A O   1 
HETATM 4969 O  O   . HOH N 9 .   ? -22.451 -51.213 -9.156  1.00 22.23  ? 1233 HOH A O   1 
HETATM 4970 O  O   . HOH N 9 .   ? -12.504 -58.333 0.000   0.50 19.51  ? 1234 HOH A O   1 
HETATM 4971 O  O   . HOH N 9 .   ? -24.712 -14.252 -5.005  1.00 55.21  ? 1235 HOH A O   1 
HETATM 4972 O  O   . HOH N 9 .   ? -37.750 -55.360 -24.090 1.00 58.89  ? 1236 HOH A O   1 
HETATM 4973 O  O   . HOH N 9 .   ? -36.246 -58.397 -20.776 1.00 39.89  ? 1237 HOH A O   1 
HETATM 4974 O  O   . HOH N 9 .   ? -21.613 -41.548 -2.141  0.50 45.66  ? 1238 HOH A O   1 
HETATM 4975 O  O   . HOH N 9 .   ? 8.531   -24.176 -36.134 1.00 45.84  ? 1239 HOH A O   1 
HETATM 4976 O  O   . HOH N 9 .   ? -22.694 -19.889 -16.009 1.00 46.22  ? 1240 HOH A O   1 
HETATM 4977 O  O   . HOH N 9 .   ? 11.485  -37.224 -19.194 1.00 54.82  ? 1241 HOH A O   1 
HETATM 4978 O  O   . HOH N 9 .   ? -12.407 -37.120 -39.721 1.00 27.70  ? 1242 HOH A O   1 
HETATM 4979 O  O   . HOH N 9 .   ? 8.127   -45.236 -29.173 1.00 59.88  ? 1243 HOH A O   1 
HETATM 4980 O  O   . HOH N 9 .   ? -20.991 -19.723 -39.065 1.00 55.85  ? 1244 HOH A O   1 
HETATM 4981 O  O   . HOH N 9 .   ? -26.593 -30.701 -23.441 1.00 45.30  ? 1245 HOH A O   1 
HETATM 4982 O  O   . HOH N 9 .   ? -13.599 -74.581 -14.151 1.00 37.65  ? 1246 HOH A O   1 
HETATM 4983 O  O   . HOH N 9 .   ? 11.330  -34.743 -33.393 1.00 36.77  ? 1247 HOH A O   1 
HETATM 4984 O  O   . HOH N 9 .   ? -41.219 -58.333 -9.904  0.50 25.81  ? 1248 HOH A O   1 
HETATM 4985 O  O   . HOH N 9 .   ? -9.270  -40.055 -39.883 1.00 47.92  ? 1249 HOH A O   1 
HETATM 4986 O  O   . HOH N 9 .   ? -17.035 -28.892 -41.027 1.00 50.50  ? 1250 HOH A O   1 
HETATM 4987 O  O   . HOH N 9 .   ? -23.188 -33.655 -36.864 1.00 32.47  ? 1251 HOH A O   1 
HETATM 4988 O  O   . HOH N 9 .   ? -19.057 -69.856 -8.222  1.00 24.29  ? 1252 HOH A O   1 
HETATM 4989 O  O   . HOH N 9 .   ? 4.102   -26.804 -29.809 1.00 33.57  ? 1253 HOH A O   1 
HETATM 4990 O  O   . HOH N 9 .   ? 2.733   -64.742 -20.875 1.00 23.01  ? 1254 HOH A O   1 
HETATM 4991 O  O   . HOH N 9 .   ? -5.351  -48.826 -28.809 1.00 24.96  ? 1255 HOH A O   1 
HETATM 4992 O  O   . HOH N 9 .   ? 10.458  -30.003 -34.518 1.00 41.41  ? 1256 HOH A O   1 
HETATM 4993 O  O   . HOH N 9 .   ? 4.963   -16.562 -21.685 1.00 55.87  ? 1257 HOH A O   1 
HETATM 4994 O  O   . HOH N 9 .   ? -20.805 -64.557 -43.412 1.00 47.83  ? 1258 HOH A O   1 
HETATM 4995 O  O   . HOH N 9 .   ? -38.430 -61.094 -14.236 1.00 29.42  ? 1259 HOH A O   1 
HETATM 4996 O  O   . HOH N 9 .   ? -21.168 -65.443 -40.938 1.00 35.71  ? 1260 HOH A O   1 
HETATM 4997 O  O   . HOH N 9 .   ? -5.017  -34.466 -20.996 1.00 40.79  ? 1261 HOH A O   1 
HETATM 4998 O  O   . HOH N 9 .   ? -13.978 -49.870 -32.245 0.50 24.13  ? 1262 HOH A O   1 
HETATM 4999 O  O   . HOH N 9 .   ? -3.039  -55.250 -18.104 1.00 24.38  ? 1263 HOH A O   1 
HETATM 5000 O  O   . HOH N 9 .   ? -34.798 -62.936 0.688   1.00 21.39  ? 1264 HOH A O   1 
HETATM 5001 O  O   . HOH N 9 .   ? -28.931 -45.903 2.609   1.00 35.88  ? 1265 HOH A O   1 
HETATM 5002 O  O   . HOH N 9 .   ? 8.585   -40.485 -31.878 1.00 51.44  ? 1266 HOH A O   1 
HETATM 5003 O  O   . HOH N 9 .   ? -26.483 -71.478 -3.506  1.00 32.61  ? 1267 HOH A O   1 
HETATM 5004 O  O   . HOH N 9 .   ? -5.284  -60.423 -0.782  1.00 34.00  ? 1268 HOH A O   1 
HETATM 5005 O  O   . HOH N 9 .   ? -33.756 -57.486 -19.609 1.00 34.36  ? 1269 HOH A O   1 
HETATM 5006 O  O   . HOH N 9 .   ? -38.736 -55.207 -18.959 1.00 36.76  ? 1270 HOH A O   1 
HETATM 5007 O  O   . HOH N 9 .   ? -29.398 -50.963 -30.097 1.00 54.36  ? 1271 HOH A O   1 
HETATM 5008 O  O   . HOH N 9 .   ? -29.854 -59.753 -19.778 1.00 29.34  ? 1272 HOH A O   1 
HETATM 5009 O  O   . HOH N 9 .   ? -23.125 -27.597 -24.833 1.00 34.60  ? 1273 HOH A O   1 
HETATM 5010 O  O   . HOH N 9 .   ? -13.609 -53.739 -1.529  1.00 21.55  ? 1274 HOH A O   1 
HETATM 5011 O  O   . HOH N 9 .   ? 10.450  -27.042 -29.422 1.00 42.10  ? 1275 HOH A O   1 
HETATM 5012 O  O   . HOH N 9 .   ? -22.243 -74.491 -11.616 1.00 27.15  ? 1276 HOH A O   1 
HETATM 5013 O  O   . HOH N 9 .   ? -5.915  -68.610 -27.536 1.00 27.69  ? 1277 HOH A O   1 
HETATM 5014 O  O   . HOH N 9 .   ? 1.017   -21.946 -45.979 1.00 51.39  ? 1278 HOH A O   1 
HETATM 5015 O  O   . HOH N 9 .   ? -19.369 -17.227 -11.274 1.00 48.65  ? 1279 HOH A O   1 
HETATM 5016 O  O   . HOH N 9 .   ? -27.917 -47.366 -0.038  1.00 36.01  ? 1280 HOH A O   1 
HETATM 5017 O  O   . HOH N 9 .   ? -40.937 -25.953 -18.003 0.50 38.92  ? 1281 HOH A O   1 
HETATM 5018 O  O   . HOH N 9 .   ? -8.583  -37.351 -19.982 1.00 50.62  ? 1282 HOH A O   1 
HETATM 5019 O  O   . HOH N 9 .   ? -17.838 -66.221 -36.253 1.00 42.56  ? 1283 HOH A O   1 
HETATM 5020 O  O   . HOH N 9 .   ? -27.975 -23.109 -26.636 1.00 29.36  ? 1284 HOH A O   1 
HETATM 5021 O  O   . HOH N 9 .   ? -32.097 -19.106 -30.869 1.00 47.78  ? 1285 HOH A O   1 
HETATM 5022 O  O   . HOH N 9 .   ? -18.777 -65.379 -7.215  1.00 17.38  ? 1286 HOH A O   1 
HETATM 5023 O  O   . HOH N 9 .   ? -24.994 -53.517 -1.892  1.00 23.70  ? 1287 HOH A O   1 
HETATM 5024 O  O   . HOH N 9 .   ? -9.123  -26.727 -44.818 1.00 34.84  ? 1288 HOH A O   1 
HETATM 5025 O  O   . HOH N 9 .   ? 1.051   -41.780 -24.555 1.00 33.12  ? 1289 HOH A O   1 
HETATM 5026 O  O   . HOH N 9 .   ? 5.108   -36.892 -23.937 0.50 35.67  ? 1290 HOH A O   1 
HETATM 5027 O  O   . HOH N 9 .   ? -17.020 -52.106 -15.566 1.00 17.68  ? 1291 HOH A O   1 
HETATM 5028 O  O   . HOH N 9 .   ? -5.928  -49.247 -21.318 1.00 24.46  ? 1292 HOH A O   1 
HETATM 5029 O  O   . HOH N 9 .   ? -27.241 -57.211 -39.950 1.00 40.61  ? 1293 HOH A O   1 
HETATM 5030 O  O   . HOH N 9 .   ? -5.646  -33.131 -17.778 1.00 39.64  ? 1294 HOH A O   1 
HETATM 5031 O  O   . HOH N 9 .   ? -4.250  -23.342 -25.484 1.00 34.88  ? 1295 HOH A O   1 
HETATM 5032 O  O   . HOH N 9 .   ? -39.718 -64.332 -2.157  1.00 42.99  ? 1296 HOH A O   1 
HETATM 5033 O  O   . HOH N 9 .   ? -39.555 -55.507 -6.204  1.00 35.52  ? 1297 HOH A O   1 
HETATM 5034 O  O   . HOH N 9 .   ? -19.135 -68.606 -1.887  1.00 38.62  ? 1298 HOH A O   1 
HETATM 5035 O  O   . HOH N 9 .   ? 1.126   -38.568 -21.547 1.00 48.13  ? 1299 HOH A O   1 
HETATM 5036 O  O   . HOH N 9 .   ? -35.290 -59.535 -0.517  1.00 41.54  ? 1300 HOH A O   1 
HETATM 5037 O  O   . HOH N 9 .   ? -15.437 -66.121 -33.744 1.00 42.48  ? 1301 HOH A O   1 
HETATM 5038 O  O   . HOH N 9 .   ? -20.522 -50.357 1.256   1.00 29.13  ? 1302 HOH A O   1 
HETATM 5039 O  O   . HOH N 9 .   ? -7.147  -49.840 -6.783  1.00 42.62  ? 1303 HOH A O   1 
HETATM 5040 O  O   . HOH N 9 .   ? -20.950 -31.835 -29.527 1.00 27.84  ? 1304 HOH A O   1 
HETATM 5041 O  O   . HOH N 9 .   ? -13.145 -68.690 -6.145  1.00 32.63  ? 1305 HOH A O   1 
HETATM 5042 O  O   . HOH N 9 .   ? -10.659 -41.616 -38.066 1.00 36.05  ? 1306 HOH A O   1 
HETATM 5043 O  O   . HOH N 9 .   ? -6.529  -42.905 -21.708 1.00 43.88  ? 1307 HOH A O   1 
HETATM 5044 O  O   . HOH N 9 .   ? -10.290 -75.390 -8.836  1.00 48.00  ? 1308 HOH A O   1 
HETATM 5045 O  O   . HOH N 9 .   ? -8.598  -17.221 -39.430 1.00 43.25  ? 1309 HOH A O   1 
HETATM 5046 O  O   . HOH N 9 .   ? -14.103 -52.364 -5.927  1.00 21.61  ? 1310 HOH A O   1 
HETATM 5047 O  O   . HOH N 9 .   ? -5.789  -50.434 -18.725 1.00 28.00  ? 1311 HOH A O   1 
HETATM 5048 O  O   . HOH N 9 .   ? -15.107 -48.708 -18.797 1.00 29.99  ? 1312 HOH A O   1 
HETATM 5049 O  O   . HOH N 9 .   ? -20.577 -67.520 -25.337 1.00 24.48  ? 1313 HOH A O   1 
HETATM 5050 O  O   . HOH N 9 .   ? -10.472 -39.283 -21.726 1.00 48.62  ? 1314 HOH A O   1 
HETATM 5051 O  O   . HOH N 9 .   ? -2.366  -39.966 -45.954 1.00 39.31  ? 1315 HOH A O   1 
HETATM 5052 O  O   . HOH N 9 .   ? -24.180 -58.196 -46.556 1.00 43.99  ? 1316 HOH A O   1 
HETATM 5053 O  O   . HOH N 9 .   ? -31.699 -60.170 -15.926 1.00 23.70  ? 1317 HOH A O   1 
HETATM 5054 O  O   . HOH N 9 .   ? -19.901 -76.449 -14.188 1.00 48.88  ? 1318 HOH A O   1 
HETATM 5055 O  O   . HOH N 9 .   ? -27.454 -15.709 -20.082 1.00 47.69  ? 1319 HOH A O   1 
HETATM 5056 O  O   . HOH N 9 .   ? -40.041 -24.105 -26.758 1.00 43.30  ? 1320 HOH A O   1 
HETATM 5057 O  O   . HOH N 9 .   ? -24.472 -69.043 -38.175 1.00 45.40  ? 1321 HOH A O   1 
HETATM 5058 O  O   . HOH N 9 .   ? -23.141 -20.968 -37.987 1.00 45.49  ? 1322 HOH A O   1 
HETATM 5059 O  O   . HOH N 9 .   ? -20.326 -38.090 -36.684 1.00 28.58  ? 1323 HOH A O   1 
HETATM 5060 O  O   . HOH N 9 .   ? -11.267 -46.573 3.953   1.00 35.50  ? 1324 HOH A O   1 
HETATM 5061 O  O   . HOH N 9 .   ? -14.791 -54.351 -4.138  1.00 20.10  ? 1325 HOH A O   1 
HETATM 5062 O  O   . HOH N 9 .   ? 6.143   -31.559 -19.549 1.00 37.09  ? 1326 HOH A O   1 
HETATM 5063 O  O   . HOH N 9 .   ? 6.339   -29.732 -44.127 1.00 44.88  ? 1327 HOH A O   1 
HETATM 5064 O  O   . HOH N 9 .   ? -30.176 -60.921 -23.011 1.00 27.29  ? 1328 HOH A O   1 
HETATM 5065 O  O   . HOH N 9 .   ? -14.175 -56.582 -1.494  1.00 18.47  ? 1329 HOH A O   1 
HETATM 5066 O  O   . HOH N 9 .   ? -15.447 -36.874 -40.433 1.00 48.36  ? 1330 HOH A O   1 
HETATM 5067 O  O   . HOH N 9 .   ? -0.442  -35.851 -28.369 1.00 28.97  ? 1331 HOH A O   1 
HETATM 5068 O  O   . HOH N 9 .   ? -12.455 -67.147 -29.547 1.00 31.75  ? 1332 HOH A O   1 
HETATM 5069 O  O   . HOH N 9 .   ? -14.908 -70.381 -3.169  1.00 45.73  ? 1333 HOH A O   1 
HETATM 5070 O  O   . HOH N 9 .   ? -8.743  -71.148 -14.797 0.36 20.28  ? 1334 HOH A O   1 
HETATM 5071 O  O   . HOH N 9 .   ? -35.911 -54.257 -3.314  1.00 25.75  ? 1335 HOH A O   1 
HETATM 5072 O  O   . HOH N 9 .   ? -22.117 -44.346 -31.275 1.00 40.72  ? 1336 HOH A O   1 
HETATM 5073 O  O   . HOH N 9 .   ? -20.187 -46.456 -25.417 1.00 33.99  ? 1337 HOH A O   1 
HETATM 5074 O  O   . HOH N 9 .   ? -3.788  -70.946 -8.888  1.00 34.37  ? 1338 HOH A O   1 
HETATM 5075 O  O   . HOH N 9 .   ? -31.012 -71.785 -13.555 1.00 53.76  ? 1339 HOH A O   1 
HETATM 5076 O  O   . HOH N 9 .   ? -28.400 -49.296 -31.727 1.00 47.72  ? 1340 HOH A O   1 
HETATM 5077 O  O   . HOH N 9 .   ? 3.528   -43.361 -43.409 1.00 50.34  ? 1341 HOH A O   1 
HETATM 5078 O  O   . HOH N 9 .   ? -18.071 -34.423 -43.108 0.50 49.59  ? 1342 HOH A O   1 
HETATM 5079 O  O   . HOH N 9 .   ? -34.062 -70.367 -18.239 1.00 35.73  ? 1343 HOH A O   1 
HETATM 5080 O  O   . HOH N 9 .   ? -38.405 -37.946 -26.544 1.00 62.20  ? 1344 HOH A O   1 
HETATM 5081 O  O   . HOH N 9 .   ? -18.195 -69.390 -24.668 1.00 35.23  ? 1345 HOH A O   1 
HETATM 5082 O  O   . HOH N 9 .   ? -4.850  -56.509 -31.702 1.00 25.47  ? 1346 HOH A O   1 
HETATM 5083 O  O   . HOH N 9 .   ? -14.519 -21.090 -17.018 1.00 46.46  ? 1347 HOH A O   1 
HETATM 5084 O  O   . HOH N 9 .   ? 3.406   -31.598 -37.497 1.00 27.22  ? 1348 HOH A O   1 
HETATM 5085 O  O   . HOH N 9 .   ? -37.471 -52.624 -12.907 1.00 28.48  ? 1349 HOH A O   1 
HETATM 5086 O  O   . HOH N 9 .   ? -35.693 -58.893 -27.218 1.00 43.93  ? 1350 HOH A O   1 
HETATM 5087 O  O   . HOH N 9 .   ? -28.068 -16.901 -32.579 1.00 36.70  ? 1351 HOH A O   1 
HETATM 5088 O  O   . HOH N 9 .   ? -4.482  -52.765 -38.723 1.00 50.90  ? 1352 HOH A O   1 
HETATM 5089 O  O   . HOH N 9 .   ? -20.929 -75.645 -5.395  1.00 52.05  ? 1353 HOH A O   1 
HETATM 5090 O  O   . HOH N 9 .   ? -15.755 -55.258 -43.658 1.00 48.80  ? 1354 HOH A O   1 
HETATM 5091 O  O   . HOH N 9 .   ? -7.861  -30.160 -46.198 1.00 40.17  ? 1355 HOH A O   1 
HETATM 5092 O  O   . HOH N 9 .   ? -22.939 -37.632 -37.282 1.00 42.78  ? 1356 HOH A O   1 
HETATM 5093 O  O   . HOH N 9 .   ? -24.787 -30.853 -39.968 1.00 49.23  ? 1357 HOH A O   1 
HETATM 5094 O  O   . HOH N 9 .   ? 9.811   -38.211 -39.522 1.00 42.42  ? 1358 HOH A O   1 
HETATM 5095 O  O   . HOH N 9 .   ? -10.090 -25.575 -12.741 1.00 47.14  ? 1359 HOH A O   1 
HETATM 5096 O  O   . HOH N 9 .   ? -22.873 -27.699 -19.011 1.00 50.47  ? 1360 HOH A O   1 
HETATM 5097 O  O   . HOH N 9 .   ? -3.746  -56.627 -7.044  1.00 27.62  ? 1361 HOH A O   1 
HETATM 5098 O  O   . HOH N 9 .   ? -23.399 -48.123 -33.779 1.00 53.08  ? 1362 HOH A O   1 
HETATM 5099 O  O   . HOH N 9 .   ? -17.338 -57.776 -43.673 1.00 32.31  ? 1363 HOH A O   1 
HETATM 5100 O  O   . HOH N 9 .   ? -18.839 -49.706 -35.255 1.00 34.23  ? 1364 HOH A O   1 
HETATM 5101 O  O   . HOH N 9 .   ? -8.856  -36.054 -44.997 1.00 57.87  ? 1365 HOH A O   1 
HETATM 5102 O  O   . HOH N 9 .   ? -34.974 -59.670 -29.449 1.00 52.45  ? 1366 HOH A O   1 
HETATM 5103 O  O   . HOH N 9 .   ? -33.915 -47.320 -15.525 1.00 54.04  ? 1367 HOH A O   1 
HETATM 5104 O  O   . HOH N 9 .   ? -27.378 -26.862 -35.876 1.00 32.08  ? 1368 HOH A O   1 
HETATM 5105 O  O   . HOH N 9 .   ? -13.842 -51.274 -43.183 1.00 49.75  ? 1369 HOH A O   1 
HETATM 5106 O  O   . HOH N 9 .   ? -10.800 -70.236 -25.317 0.36 22.28  ? 1370 HOH A O   1 
HETATM 5107 O  O   . HOH N 9 .   ? -13.601 -11.578 -32.606 1.00 49.12  ? 1371 HOH A O   1 
HETATM 5108 O  O   . HOH N 9 .   ? -22.974 -75.415 -9.117  1.00 39.89  ? 1372 HOH A O   1 
HETATM 5109 O  O   . HOH N 9 .   ? -12.048 -44.265 -16.510 1.00 43.11  ? 1373 HOH A O   1 
HETATM 5110 O  O   . HOH N 9 .   ? -18.985 -45.451 -9.272  1.00 51.17  ? 1374 HOH A O   1 
HETATM 5111 O  O   . HOH N 9 .   ? -25.420 -23.702 -41.831 1.00 56.68  ? 1375 HOH A O   1 
HETATM 5112 O  O   . HOH N 9 .   ? -15.927 -27.336 -46.099 1.00 51.66  ? 1376 HOH A O   1 
HETATM 5113 O  O   . HOH N 9 .   ? -27.576 -40.479 -5.460  1.00 57.68  ? 1377 HOH A O   1 
HETATM 5114 O  O   . HOH N 9 .   ? -20.356 -31.562 -26.758 1.00 31.36  ? 1378 HOH A O   1 
HETATM 5115 O  O   . HOH N 9 .   ? -0.254  -48.279 -36.495 1.00 36.53  ? 1379 HOH A O   1 
HETATM 5116 O  O   . HOH N 9 .   ? -26.828 -51.380 -1.725  1.00 29.40  ? 1380 HOH A O   1 
HETATM 5117 O  O   . HOH N 9 .   ? -22.611 -29.690 -14.592 1.00 64.50  ? 1381 HOH A O   1 
HETATM 5118 O  O   . HOH N 9 .   ? -7.483  -51.419 -10.425 1.00 48.15  ? 1382 HOH A O   1 
HETATM 5119 O  O   . HOH N 9 .   ? -5.873  -69.229 -7.280  1.00 30.48  ? 1383 HOH A O   1 
HETATM 5120 O  O   . HOH N 9 .   ? -23.609 -49.875 -42.013 1.00 38.53  ? 1384 HOH A O   1 
HETATM 5121 O  O   . HOH N 9 .   ? -35.033 -67.718 -5.463  1.00 41.44  ? 1385 HOH A O   1 
HETATM 5122 O  O   . HOH N 9 .   ? -30.018 -61.628 -33.070 1.00 44.20  ? 1386 HOH A O   1 
HETATM 5123 O  O   . HOH N 9 .   ? -37.641 -68.479 -12.394 1.00 39.97  ? 1387 HOH A O   1 
HETATM 5124 O  O   . HOH N 9 .   ? -4.000  -34.382 -14.539 1.00 51.18  ? 1388 HOH A O   1 
HETATM 5125 O  O   . HOH N 9 .   ? -19.191 -64.757 -3.074  1.00 28.75  ? 1389 HOH A O   1 
HETATM 5126 O  O   . HOH N 9 .   ? -12.797 -37.960 -22.546 1.00 49.71  ? 1390 HOH A O   1 
HETATM 5127 O  O   . HOH N 9 .   ? -22.215 -31.671 -39.747 1.00 37.06  ? 1391 HOH A O   1 
HETATM 5128 O  O   . HOH N 9 .   ? -7.057  -57.632 -1.064  1.00 42.23  ? 1392 HOH A O   1 
HETATM 5129 O  O   . HOH N 9 .   ? -7.744  -62.195 -33.580 1.00 42.93  ? 1393 HOH A O   1 
HETATM 5130 O  O   . HOH N 9 .   ? -6.464  -37.085 -20.757 1.00 45.77  ? 1394 HOH A O   1 
HETATM 5131 O  O   . HOH N 9 .   ? -31.162 -45.338 -15.604 1.00 49.74  ? 1395 HOH A O   1 
HETATM 5132 O  O   . HOH N 9 .   ? -8.453  -31.185 -15.575 1.00 46.25  ? 1396 HOH A O   1 
HETATM 5133 O  O   . HOH N 9 .   ? -4.044  -57.268 -13.514 1.00 35.40  ? 1397 HOH A O   1 
HETATM 5134 O  O   . HOH N 9 .   ? 13.424  -30.489 -19.863 1.00 44.02  ? 1398 HOH A O   1 
HETATM 5135 O  O   . HOH N 9 .   ? -23.472 -45.480 -8.912  1.00 46.02  ? 1399 HOH A O   1 
HETATM 5136 O  O   . HOH N 9 .   ? -11.464 -72.107 -15.373 0.36 16.84  ? 1400 HOH A O   1 
HETATM 5137 O  O   . HOH N 9 .   ? 0.800   -31.478 -47.226 1.00 40.64  ? 1401 HOH A O   1 
HETATM 5138 O  O   . HOH N 9 .   ? -17.391 -71.665 -22.683 1.00 44.31  ? 1402 HOH A O   1 
HETATM 5139 O  O   . HOH N 9 .   ? -3.029  -58.281 -24.672 1.00 19.69  ? 1403 HOH A O   1 
HETATM 5140 O  O   . HOH N 9 .   ? -20.172 -70.866 -5.797  1.00 32.78  ? 1404 HOH A O   1 
HETATM 5141 O  O   . HOH N 9 .   ? -14.850 -57.340 -41.922 1.00 29.26  ? 1405 HOH A O   1 
HETATM 5142 O  O   . HOH N 9 .   ? -1.029  -32.575 -25.610 1.00 28.23  ? 1406 HOH A O   1 
HETATM 5143 O  O   . HOH N 9 .   ? -13.142 -42.292 -18.843 0.50 43.35  ? 1407 HOH A O   1 
HETATM 5144 O  O   . HOH N 9 .   ? -22.999 -63.301 -23.450 1.00 42.86  ? 1408 HOH A O   1 
HETATM 5145 O  O   . HOH N 9 .   ? -26.695 -67.946 -27.850 1.00 25.68  ? 1409 HOH A O   1 
HETATM 5146 O  O   . HOH N 9 .   ? 3.370   -34.256 -14.502 1.00 57.64  ? 1410 HOH A O   1 
HETATM 5147 O  O   . HOH N 9 .   ? -17.636 -41.873 -37.180 1.00 42.82  ? 1411 HOH A O   1 
HETATM 5148 O  O   . HOH N 9 .   ? -13.436 -32.704 -20.586 1.00 39.13  ? 1412 HOH A O   1 
HETATM 5149 O  O   . HOH N 9 .   ? 8.467   -43.806 -32.603 1.00 60.45  ? 1413 HOH A O   1 
HETATM 5150 O  O   . HOH N 9 .   ? -19.201 -14.599 -38.211 1.00 68.66  ? 1414 HOH A O   1 
HETATM 5151 O  O   . HOH N 9 .   ? 4.892   -69.180 -21.812 1.00 37.59  ? 1415 HOH A O   1 
HETATM 5152 O  O   . HOH N 9 .   ? -37.532 -60.777 -0.777  1.00 60.39  ? 1416 HOH A O   1 
HETATM 5153 O  O   . HOH N 9 .   ? 0.225   -45.682 -37.103 1.00 47.18  ? 1417 HOH A O   1 
HETATM 5154 O  O   . HOH N 9 .   ? 3.778   -41.610 -24.256 0.50 29.08  ? 1418 HOH A O   1 
HETATM 5155 O  O   . HOH N 9 .   ? -8.970  -71.938 -26.490 0.36 25.27  ? 1419 HOH A O   1 
HETATM 5156 O  O   . HOH N 9 .   ? -26.698 -28.291 -42.758 1.00 58.88  ? 1420 HOH A O   1 
HETATM 5157 O  O   . HOH N 9 .   ? -8.534  -68.354 -28.412 1.00 45.56  ? 1421 HOH A O   1 
HETATM 5158 O  O   . HOH N 9 .   ? -35.716 -51.040 -23.219 1.00 48.79  ? 1422 HOH A O   1 
HETATM 5159 O  O   . HOH N 9 .   ? 0.023   -45.997 -42.915 1.00 51.68  ? 1423 HOH A O   1 
HETATM 5160 O  O   . HOH N 9 .   ? 0.684   -70.821 -21.355 1.00 39.38  ? 1424 HOH A O   1 
HETATM 5161 O  O   . HOH N 9 .   ? -31.694 -12.982 -9.621  1.00 58.96  ? 1425 HOH A O   1 
HETATM 5162 O  O   . HOH N 9 .   ? -23.235 -37.106 -32.703 1.00 48.04  ? 1426 HOH A O   1 
HETATM 5163 O  O   . HOH N 9 .   ? -9.418  -55.472 -41.604 1.00 59.05  ? 1427 HOH A O   1 
HETATM 5164 O  O   . HOH N 9 .   ? 4.450   -62.606 -20.237 1.00 20.59  ? 1428 HOH A O   1 
HETATM 5165 O  O   . HOH N 9 .   ? 0.000   -58.333 -16.749 0.50 43.30  ? 1429 HOH A O   1 
HETATM 5166 O  O   . HOH N 9 .   ? -16.330 -49.367 -16.241 1.00 21.89  ? 1430 HOH A O   1 
HETATM 5167 O  O   . HOH N 9 .   ? -30.166 -34.063 -32.677 1.00 57.21  ? 1431 HOH A O   1 
HETATM 5168 O  O   . HOH N 9 .   ? -38.333 -28.246 -27.234 1.00 48.52  ? 1432 HOH A O   1 
HETATM 5169 O  O   . HOH N 9 .   ? -19.875 -43.911 -38.050 1.00 47.57  ? 1433 HOH A O   1 
HETATM 5170 O  O   . HOH N 9 .   ? -25.320 -20.676 -4.972  1.00 52.20  ? 1434 HOH A O   1 
HETATM 5171 O  O   . HOH N 9 .   ? -10.537 -34.280 -44.311 1.00 50.92  ? 1435 HOH A O   1 
HETATM 5172 O  O   . HOH N 9 .   ? -5.697  -59.040 -36.808 1.00 52.36  ? 1436 HOH A O   1 
HETATM 5173 O  O   . HOH N 9 .   ? -17.868 -47.289 -15.230 1.00 35.51  ? 1437 HOH A O   1 
HETATM 5174 O  O   . HOH N 9 .   ? -2.864  -55.796 -28.882 1.00 26.11  ? 1438 HOH A O   1 
HETATM 5175 O  O   . HOH N 9 .   ? -27.232 -73.890 -4.627  1.00 37.54  ? 1439 HOH A O   1 
HETATM 5176 O  O   . HOH N 9 .   ? -29.316 -69.459 -40.064 1.00 56.71  ? 1440 HOH A O   1 
HETATM 5177 O  O   . HOH N 9 .   ? -12.471 -75.926 -26.732 1.00 63.32  ? 1441 HOH A O   1 
HETATM 5178 O  O   . HOH N 9 .   ? -30.801 -16.757 -32.260 1.00 43.30  ? 1442 HOH A O   1 
HETATM 5179 O  O   . HOH N 9 .   ? -36.729 -64.877 0.044   1.00 43.22  ? 1443 HOH A O   1 
HETATM 5180 O  O   . HOH N 9 .   ? -36.469 -61.208 -20.535 1.00 60.62  ? 1444 HOH A O   1 
HETATM 5181 O  O   . HOH N 9 .   ? -34.205 -49.658 -10.308 1.00 39.89  ? 1445 HOH A O   1 
HETATM 5182 O  O   . HOH N 9 .   ? -7.457  -29.954 -13.663 1.00 55.15  ? 1446 HOH A O   1 
HETATM 5183 O  O   . HOH N 9 .   ? -3.373  -51.866 2.628   1.00 64.22  ? 1447 HOH A O   1 
HETATM 5184 O  O   . HOH N 9 .   ? -34.857 -70.447 -13.586 1.00 69.96  ? 1448 HOH A O   1 
HETATM 5185 O  O   . HOH N 9 .   ? -10.791 -17.842 -40.702 1.00 47.81  ? 1449 HOH A O   1 
HETATM 5186 O  O   . HOH N 9 .   ? -13.522 -45.190 -9.948  1.00 57.73  ? 1450 HOH A O   1 
HETATM 5187 O  O   . HOH N 9 .   ? -34.656 -49.601 -20.801 1.00 51.36  ? 1451 HOH A O   1 
HETATM 5188 O  O   . HOH N 9 .   ? -19.221 -39.752 -38.535 1.00 44.00  ? 1452 HOH A O   1 
HETATM 5189 O  O   . HOH N 9 .   ? -34.584 -70.085 -9.375  1.00 54.24  ? 1453 HOH A O   1 
HETATM 5190 O  O   . HOH N 9 .   ? -15.712 -69.331 -5.967  1.00 23.82  ? 1454 HOH A O   1 
HETATM 5191 O  O   . HOH N 9 .   ? -13.101 -70.143 -23.141 0.36 32.78  ? 1455 HOH A O   1 
HETATM 5192 O  O   . HOH N 9 .   ? -2.899  -51.927 -15.653 1.00 54.33  ? 1456 HOH A O   1 
HETATM 5193 O  O   . HOH N 9 .   ? -13.661 -70.004 -20.295 0.36 40.87  ? 1457 HOH A O   1 
HETATM 5194 O  O   . HOH N 9 .   ? -5.615  -31.482 -48.049 1.00 52.67  ? 1458 HOH A O   1 
HETATM 5195 O  O   . HOH N 9 .   ? -37.897 -52.388 -4.059  1.00 38.55  ? 1459 HOH A O   1 
HETATM 5196 O  O   . HOH N 9 .   ? -10.484 -38.211 -43.831 0.50 45.08  ? 1460 HOH A O   1 
HETATM 5197 O  O   . HOH N 9 .   ? -17.936 -27.995 -44.711 1.00 47.72  ? 1461 HOH A O   1 
HETATM 5198 O  O   . HOH N 9 .   ? -4.149  -73.937 -5.291  0.36 46.21  ? 1462 HOH A O   1 
HETATM 5199 O  O   . HOH N 9 .   ? 0.367   -62.558 -17.814 1.00 31.93  ? 1463 HOH A O   1 
HETATM 5200 O  O   . HOH N 9 .   ? -15.457 -45.872 -19.568 1.00 45.73  ? 1464 HOH A O   1 
HETATM 5201 O  O   . HOH N 9 .   ? -17.071 -39.093 -40.019 1.00 51.47  ? 1465 HOH A O   1 
HETATM 5202 O  O   . HOH N 9 .   ? -15.671 -41.910 -38.681 1.00 33.56  ? 1466 HOH A O   1 
HETATM 5203 O  O   . HOH N 9 .   ? -38.767 -51.394 -20.160 1.00 53.94  ? 1467 HOH A O   1 
HETATM 5204 O  O   . HOH N 9 .   ? -25.732 -19.959 -38.961 1.00 53.59  ? 1468 HOH A O   1 
HETATM 5205 O  O   . HOH N 9 .   ? -24.996 -28.546 -22.756 1.00 51.39  ? 1469 HOH A O   1 
HETATM 5206 O  O   . HOH N 9 .   ? -42.408 -66.611 -9.914  1.00 59.04  ? 1470 HOH A O   1 
HETATM 5207 O  O   . HOH N 9 .   ? -15.746 -9.446  -34.069 1.00 52.12  ? 1471 HOH A O   1 
HETATM 5208 O  O   . HOH N 9 .   ? -36.698 -56.537 -4.341  1.00 52.87  ? 1472 HOH A O   1 
HETATM 5209 O  O   . HOH N 9 .   ? -3.233  -52.167 -4.318  1.00 64.28  ? 1473 HOH A O   1 
HETATM 5210 O  O   . HOH N 9 .   ? -31.042 -59.783 -34.450 1.00 48.28  ? 1474 HOH A O   1 
HETATM 5211 O  O   . HOH N 9 .   ? -15.788 -44.602 -10.451 1.00 71.54  ? 1475 HOH A O   1 
HETATM 5212 O  O   . HOH N 9 .   ? -12.390 -76.808 -13.376 0.36 33.33  ? 1476 HOH A O   1 
HETATM 5213 O  O   . HOH N 9 .   ? -25.446 -76.464 -9.021  1.00 59.46  ? 1477 HOH A O   1 
HETATM 5214 O  O   . HOH N 9 .   ? -20.314 -59.513 -48.189 1.00 65.45  ? 1478 HOH A O   1 
HETATM 5215 O  O   . HOH N 9 .   ? -5.401  -65.389 -31.214 1.00 48.62  ? 1479 HOH A O   1 
HETATM 5216 O  O   . HOH N 9 .   ? -23.455 -75.419 -13.899 1.00 50.33  ? 1480 HOH A O   1 
HETATM 5217 O  O   . HOH N 9 .   ? -24.272 -36.113 -35.176 1.00 45.79  ? 1481 HOH A O   1 
HETATM 5218 O  O   . HOH N 9 .   ? -41.410 -56.802 -13.625 1.00 27.10  ? 1482 HOH A O   1 
HETATM 5219 O  O   . HOH N 9 .   ? -25.211 -27.822 -19.952 1.00 49.40  ? 1483 HOH A O   1 
HETATM 5220 O  O   . HOH N 9 .   ? -41.766 -23.858 -19.034 0.50 47.36  ? 1484 HOH A O   1 
HETATM 5221 O  O   . HOH N 9 .   ? 0.000   -58.333 -28.549 0.50 27.85  ? 1485 HOH A O   1 
HETATM 5222 O  O   . HOH N 9 .   ? -3.343  -50.683 -18.108 1.00 44.68  ? 1486 HOH A O   1 
HETATM 5223 O  O   . HOH N 9 .   ? -9.574  -23.843 -3.866  1.00 63.92  ? 1487 HOH A O   1 
HETATM 5224 O  O   . HOH N 9 .   ? -6.164  -45.248 -17.807 1.00 56.56  ? 1488 HOH A O   1 
HETATM 5225 O  O   . HOH N 9 .   ? 16.477  -34.202 -26.930 1.00 64.92  ? 1489 HOH A O   1 
HETATM 5226 O  O   . HOH N 9 .   ? -35.926 -48.266 -14.046 1.00 44.35  ? 1490 HOH A O   1 
HETATM 5227 O  O   . HOH N 9 .   ? -30.553 -10.501 -38.854 1.00 61.42  ? 1491 HOH A O   1 
HETATM 5228 O  O   . HOH N 9 .   ? -28.431 -65.297 -42.387 1.00 51.01  ? 1492 HOH A O   1 
HETATM 5229 O  O   . HOH N 9 .   ? -3.925  -49.397 3.118   1.00 67.37  ? 1493 HOH A O   1 
HETATM 5230 O  O   . HOH N 9 .   ? -1.625  -55.638 -6.059  1.00 43.20  ? 1494 HOH A O   1 
HETATM 5231 O  O   . HOH N 9 .   ? -28.942 -21.597 -42.877 1.00 50.05  ? 1495 HOH A O   1 
HETATM 5232 O  O   . HOH N 9 .   ? -5.509  -50.830 -40.923 1.00 53.14  ? 1496 HOH A O   1 
HETATM 5233 O  O   . HOH N 9 .   ? -18.194 -67.960 -6.412  1.00 21.65  ? 1497 HOH A O   1 
HETATM 5234 O  O   . HOH N 9 .   ? -1.269  -55.293 -0.797  1.00 39.79  ? 1498 HOH A O   1 
HETATM 5235 O  O   . HOH N 9 .   ? -4.563  -66.720 -6.300  1.00 55.50  ? 1499 HOH A O   1 
HETATM 5236 O  O   . HOH N 9 .   ? -2.987  -56.692 -33.866 1.00 44.99  ? 1500 HOH A O   1 
HETATM 5237 O  O   . HOH N 9 .   ? -1.188  -58.623 -32.230 1.00 63.69  ? 1501 HOH A O   1 
HETATM 5238 O  O   . HOH N 9 .   ? -19.960 -68.432 -4.387  1.00 24.97  ? 1502 HOH A O   1 
HETATM 5239 O  O   . HOH N 9 .   ? -2.795  -59.700 -0.641  1.00 30.39  ? 1503 HOH A O   1 
HETATM 5240 O  O   . HOH N 9 .   ? -10.055 -28.010 -12.014 1.00 52.31  ? 1504 HOH A O   1 
HETATM 5241 O  O   . HOH N 9 .   ? 0.732   -42.899 -22.003 1.00 48.99  ? 1505 HOH A O   1 
HETATM 5242 O  O   . HOH N 9 .   ? -12.352 -36.708 -42.624 1.00 48.95  ? 1506 HOH A O   1 
HETATM 5243 O  O   . HOH N 9 .   ? -3.030  -59.965 -6.689  1.00 51.80  ? 1507 HOH A O   1 
HETATM 5244 O  O   . HOH N 9 .   ? -1.739  -59.519 -3.174  1.00 46.58  ? 1508 HOH A O   1 
HETATM 5245 O  O   . HOH N 9 .   ? 15.524  -14.738 -40.651 1.00 65.41  ? 1509 HOH A O   1 
HETATM 5246 O  O   . HOH N 9 .   ? -5.522  -64.228 -6.664  1.00 30.34  ? 1510 HOH A O   1 
HETATM 5247 O  O   . HOH N 9 .   ? -4.071  -60.709 -10.324 1.00 46.50  ? 1511 HOH A O   1 
HETATM 5248 O  O   . HOH N 9 .   ? 10.070  -21.008 -25.903 1.00 45.37  ? 1512 HOH A O   1 
HETATM 5249 O  O   . HOH N 9 .   ? -32.526 -67.047 -23.302 1.00 66.78  ? 1513 HOH A O   1 
HETATM 5250 O  O   . HOH N 9 .   ? -44.282 -68.266 -16.297 1.00 65.07  ? 1514 HOH A O   1 
HETATM 5251 O  O   . HOH N 9 .   ? -28.161 -29.660 -18.977 1.00 78.27  ? 1515 HOH A O   1 
HETATM 5252 O  O   . HOH N 9 .   ? -28.318 -55.926 -45.151 1.00 55.04  ? 1516 HOH A O   1 
HETATM 5253 O  O   . HOH N 9 .   ? 12.960  -25.450 -27.147 1.00 54.80  ? 1517 HOH A O   1 
HETATM 5254 O  O   . HOH N 9 .   ? -43.033 -60.453 -2.005  1.00 53.42  ? 1518 HOH A O   1 
HETATM 5255 O  O   . HOH N 9 .   ? -3.982  -62.732 -9.034  1.00 47.05  ? 1519 HOH A O   1 
# 
