data_7I2R
# 
_entry.id   7I2R 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   7I2R         pdb_00007i2r 10.2210/pdb7i2r/pdb 
WWPDB D_1001408242 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-02 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.entry_id                        7I2R 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.recvd_initial_deposition_date   2025-03-06 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.SG_entry                        ? 
_pdbx_database_status.pdb_format_compatible           Y 
_pdbx_database_status.methods_development_category    ? 
# 
_pdbx_contact_author.id                 1 
_pdbx_contact_author.email              fr193@cabm.rutgers.edu 
_pdbx_contact_author.name_first         'Francesc Xavier' 
_pdbx_contact_author.name_last          Ruiz 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0457-0030 
_pdbx_contact_author.name_mi            ? 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Aschenbrenner, J.C.' 1  ? 
'Saini, M.'           2  ? 
'Chopra, A.'          3  ? 
'Marples, P.G.'       4  ? 
'Balcomb, B.H.'       5  ? 
'Lithgo, R.M.'        6  ? 
'Fearon, D.'          7  ? 
'von Delft, F.'       8  ? 
'Ruiz, F.X.'          9  ? 
'Arnold, E.'          10 ? 
# 
_citation.id                        primary 
_citation.title                     
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_volume            ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.year                      ? 
_citation.journal_id_ASTM           ? 
_citation.country                   ? 
_citation.journal_id_ISSN           ? 
_citation.journal_id_CSD            0353 
_citation.book_publisher            ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_DOI      ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.identifier_ORCID 
_citation_author.ordinal 
primary 'Aschenbrenner, J.C.' ? 1  
primary 'Saini, M.'           ? 2  
primary 'Chopra, A.'          ? 3  
primary 'Marples, P.G.'       ? 4  
primary 'Balcomb, B.H.'       ? 5  
primary 'Lithgo, R.M.'        ? 6  
primary 'Fearon, D.'          ? 7  
primary 'von Delft, F.'       ? 8  
primary 'Ruiz, F.X.'          ? 9  
primary 'Arnold, E.'          ? 10 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'NS5 RNA-dependent RNA polymerase'                73890.008 1   ? ? ? ? 
2 non-polymer syn 'ZINC ION'                                        65.409    2   ? ? ? ? 
3 non-polymer syn '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'            195.237   1   ? ? ? ? 
4 non-polymer syn 'DIMETHYL SULFOXIDE'                              78.133    2   ? ? ? ? 
5 non-polymer syn 'PHOSPHATE ION'                                   94.971    2   ? ? ? ? 
6 non-polymer syn 'DI(HYDROXYETHYL)ETHER'                           106.120   1   ? ? ? ? 
7 non-polymer syn 'CHLORIDE ION'                                    35.453    1   ? ? ? ? 
8 non-polymer syn '(azepan-1-yl)(2H-1,3-benzodioxol-5-yl)methanone' 247.290   1   ? ? ? ? 
9 water       nat water                                             18.015    303 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION'                                        ZN  
3 '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'            MES 
4 'DIMETHYL SULFOXIDE'                              DMS 
5 'PHOSPHATE ION'                                   PO4 
6 'DI(HYDROXYETHYL)ETHER'                           PEG 
7 'CHLORIDE ION'                                    CL  
8 '(azepan-1-yl)(2H-1,3-benzodioxol-5-yl)methanone' JGP 
9 water                                             HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PRO n 
1 3   GLY n 
1 4   ILE n 
1 5   GLU n 
1 6   SER n 
1 7   GLU n 
1 8   THR n 
1 9   PRO n 
1 10  ASN n 
1 11  LEU n 
1 12  ASP n 
1 13  ILE n 
1 14  ILE n 
1 15  GLY n 
1 16  LYS n 
1 17  ARG n 
1 18  ILE n 
1 19  GLU n 
1 20  LYS n 
1 21  ILE n 
1 22  LYS n 
1 23  GLN n 
1 24  GLU n 
1 25  HIS n 
1 26  GLU n 
1 27  THR n 
1 28  SER n 
1 29  TRP n 
1 30  HIS n 
1 31  TYR n 
1 32  ASP n 
1 33  GLN n 
1 34  ASP n 
1 35  HIS n 
1 36  PRO n 
1 37  TYR n 
1 38  LYS n 
1 39  THR n 
1 40  TRP n 
1 41  ALA n 
1 42  TYR n 
1 43  HIS n 
1 44  GLY n 
1 45  SER n 
1 46  TYR n 
1 47  GLU n 
1 48  THR n 
1 49  LYS n 
1 50  GLN n 
1 51  THR n 
1 52  GLY n 
1 53  SER n 
1 54  ALA n 
1 55  SER n 
1 56  SER n 
1 57  MET n 
1 58  VAL n 
1 59  ASN n 
1 60  GLY n 
1 61  VAL n 
1 62  VAL n 
1 63  ARG n 
1 64  LEU n 
1 65  LEU n 
1 66  THR n 
1 67  LYS n 
1 68  PRO n 
1 69  TRP n 
1 70  ASP n 
1 71  ILE n 
1 72  ILE n 
1 73  PRO n 
1 74  MET n 
1 75  VAL n 
1 76  THR n 
1 77  GLN n 
1 78  MET n 
1 79  ALA n 
1 80  MET n 
1 81  THR n 
1 82  ASP n 
1 83  THR n 
1 84  THR n 
1 85  PRO n 
1 86  PHE n 
1 87  GLY n 
1 88  GLN n 
1 89  GLN n 
1 90  ARG n 
1 91  VAL n 
1 92  PHE n 
1 93  LYS n 
1 94  GLU n 
1 95  LYS n 
1 96  VAL n 
1 97  ASP n 
1 98  THR n 
1 99  ARG n 
1 100 THR n 
1 101 GLN n 
1 102 GLU n 
1 103 PRO n 
1 104 LYS n 
1 105 GLU n 
1 106 GLY n 
1 107 THR n 
1 108 LYS n 
1 109 LYS n 
1 110 LEU n 
1 111 MET n 
1 112 LYS n 
1 113 ILE n 
1 114 THR n 
1 115 ALA n 
1 116 GLU n 
1 117 TRP n 
1 118 LEU n 
1 119 TRP n 
1 120 LYS n 
1 121 GLU n 
1 122 LEU n 
1 123 GLY n 
1 124 LYS n 
1 125 LYS n 
1 126 LYS n 
1 127 THR n 
1 128 PRO n 
1 129 ARG n 
1 130 MET n 
1 131 CYS n 
1 132 THR n 
1 133 ARG n 
1 134 GLU n 
1 135 GLU n 
1 136 PHE n 
1 137 THR n 
1 138 ARG n 
1 139 LYS n 
1 140 VAL n 
1 141 ARG n 
1 142 SER n 
1 143 ASN n 
1 144 ALA n 
1 145 ALA n 
1 146 LEU n 
1 147 GLY n 
1 148 ALA n 
1 149 ILE n 
1 150 PHE n 
1 151 THR n 
1 152 ASP n 
1 153 GLU n 
1 154 ASN n 
1 155 LYS n 
1 156 TRP n 
1 157 LYS n 
1 158 SER n 
1 159 ALA n 
1 160 ARG n 
1 161 GLU n 
1 162 ALA n 
1 163 VAL n 
1 164 GLU n 
1 165 ASP n 
1 166 SER n 
1 167 GLY n 
1 168 PHE n 
1 169 TRP n 
1 170 GLU n 
1 171 LEU n 
1 172 VAL n 
1 173 ASP n 
1 174 LYS n 
1 175 GLU n 
1 176 ARG n 
1 177 ASN n 
1 178 LEU n 
1 179 HIS n 
1 180 LEU n 
1 181 GLU n 
1 182 GLY n 
1 183 LYS n 
1 184 CYS n 
1 185 GLU n 
1 186 THR n 
1 187 CYS n 
1 188 VAL n 
1 189 TYR n 
1 190 ASN n 
1 191 MET n 
1 192 MET n 
1 193 GLY n 
1 194 LYS n 
1 195 ARG n 
1 196 GLU n 
1 197 LYS n 
1 198 LYS n 
1 199 LEU n 
1 200 GLY n 
1 201 GLU n 
1 202 PHE n 
1 203 GLY n 
1 204 LYS n 
1 205 ALA n 
1 206 LYS n 
1 207 GLY n 
1 208 SER n 
1 209 ARG n 
1 210 ALA n 
1 211 ILE n 
1 212 TRP n 
1 213 TYR n 
1 214 MET n 
1 215 TRP n 
1 216 LEU n 
1 217 GLY n 
1 218 ALA n 
1 219 ARG n 
1 220 PHE n 
1 221 LEU n 
1 222 GLU n 
1 223 PHE n 
1 224 GLU n 
1 225 ALA n 
1 226 LEU n 
1 227 GLY n 
1 228 PHE n 
1 229 LEU n 
1 230 ASN n 
1 231 GLU n 
1 232 ASP n 
1 233 HIS n 
1 234 TRP n 
1 235 PHE n 
1 236 SER n 
1 237 ARG n 
1 238 GLU n 
1 239 ASN n 
1 240 SER n 
1 241 LEU n 
1 242 SER n 
1 243 GLY n 
1 244 VAL n 
1 245 GLU n 
1 246 GLY n 
1 247 GLU n 
1 248 GLY n 
1 249 LEU n 
1 250 HIS n 
1 251 LYS n 
1 252 LEU n 
1 253 GLY n 
1 254 TYR n 
1 255 ILE n 
1 256 LEU n 
1 257 ARG n 
1 258 ASP n 
1 259 VAL n 
1 260 SER n 
1 261 LYS n 
1 262 LYS n 
1 263 GLU n 
1 264 GLY n 
1 265 GLY n 
1 266 ALA n 
1 267 MET n 
1 268 TYR n 
1 269 ALA n 
1 270 ASP n 
1 271 ASP n 
1 272 THR n 
1 273 ALA n 
1 274 GLY n 
1 275 TRP n 
1 276 ASP n 
1 277 THR n 
1 278 ARG n 
1 279 ILE n 
1 280 THR n 
1 281 LEU n 
1 282 GLU n 
1 283 ASP n 
1 284 LEU n 
1 285 LYS n 
1 286 ASN n 
1 287 GLU n 
1 288 GLU n 
1 289 MET n 
1 290 VAL n 
1 291 THR n 
1 292 ASN n 
1 293 HIS n 
1 294 MET n 
1 295 GLU n 
1 296 GLY n 
1 297 GLU n 
1 298 HIS n 
1 299 LYS n 
1 300 LYS n 
1 301 LEU n 
1 302 ALA n 
1 303 GLU n 
1 304 ALA n 
1 305 ILE n 
1 306 PHE n 
1 307 LYS n 
1 308 LEU n 
1 309 THR n 
1 310 TYR n 
1 311 GLN n 
1 312 ASN n 
1 313 LYS n 
1 314 VAL n 
1 315 VAL n 
1 316 ARG n 
1 317 VAL n 
1 318 GLN n 
1 319 ARG n 
1 320 PRO n 
1 321 THR n 
1 322 PRO n 
1 323 ARG n 
1 324 GLY n 
1 325 THR n 
1 326 VAL n 
1 327 MET n 
1 328 ASP n 
1 329 ILE n 
1 330 ILE n 
1 331 SER n 
1 332 ARG n 
1 333 ARG n 
1 334 ASP n 
1 335 GLN n 
1 336 ARG n 
1 337 GLY n 
1 338 SER n 
1 339 GLY n 
1 340 GLN n 
1 341 VAL n 
1 342 VAL n 
1 343 THR n 
1 344 TYR n 
1 345 GLY n 
1 346 LEU n 
1 347 ASN n 
1 348 THR n 
1 349 PHE n 
1 350 THR n 
1 351 ASN n 
1 352 MET n 
1 353 GLU n 
1 354 ALA n 
1 355 GLN n 
1 356 LEU n 
1 357 ILE n 
1 358 ARG n 
1 359 GLN n 
1 360 MET n 
1 361 GLU n 
1 362 GLY n 
1 363 GLU n 
1 364 GLY n 
1 365 VAL n 
1 366 PHE n 
1 367 LYS n 
1 368 SER n 
1 369 ILE n 
1 370 GLN n 
1 371 HIS n 
1 372 LEU n 
1 373 THR n 
1 374 VAL n 
1 375 THR n 
1 376 GLU n 
1 377 GLU n 
1 378 ILE n 
1 379 ALA n 
1 380 VAL n 
1 381 LYS n 
1 382 ASN n 
1 383 TRP n 
1 384 LEU n 
1 385 VAL n 
1 386 ARG n 
1 387 VAL n 
1 388 GLY n 
1 389 ARG n 
1 390 GLU n 
1 391 ARG n 
1 392 LEU n 
1 393 SER n 
1 394 ARG n 
1 395 MET n 
1 396 ALA n 
1 397 ILE n 
1 398 SER n 
1 399 GLY n 
1 400 ASP n 
1 401 ASP n 
1 402 CYS n 
1 403 VAL n 
1 404 VAL n 
1 405 LYS n 
1 406 PRO n 
1 407 LEU n 
1 408 ASP n 
1 409 ASP n 
1 410 ARG n 
1 411 PHE n 
1 412 ALA n 
1 413 SER n 
1 414 ALA n 
1 415 LEU n 
1 416 THR n 
1 417 ALA n 
1 418 LEU n 
1 419 ASN n 
1 420 ASP n 
1 421 MET n 
1 422 GLY n 
1 423 LYS n 
1 424 VAL n 
1 425 ARG n 
1 426 LYS n 
1 427 ASP n 
1 428 ILE n 
1 429 GLN n 
1 430 GLN n 
1 431 TRP n 
1 432 GLU n 
1 433 PRO n 
1 434 SER n 
1 435 ARG n 
1 436 GLY n 
1 437 TRP n 
1 438 ASN n 
1 439 ASP n 
1 440 TRP n 
1 441 THR n 
1 442 GLN n 
1 443 VAL n 
1 444 PRO n 
1 445 PHE n 
1 446 CYS n 
1 447 SER n 
1 448 HIS n 
1 449 HIS n 
1 450 PHE n 
1 451 HIS n 
1 452 GLU n 
1 453 LEU n 
1 454 ILE n 
1 455 MET n 
1 456 LYS n 
1 457 ASP n 
1 458 GLY n 
1 459 ARG n 
1 460 VAL n 
1 461 LEU n 
1 462 VAL n 
1 463 VAL n 
1 464 PRO n 
1 465 CYS n 
1 466 ARG n 
1 467 ASN n 
1 468 GLN n 
1 469 ASP n 
1 470 GLU n 
1 471 LEU n 
1 472 ILE n 
1 473 GLY n 
1 474 ARG n 
1 475 ALA n 
1 476 ARG n 
1 477 ILE n 
1 478 SER n 
1 479 GLN n 
1 480 GLY n 
1 481 ALA n 
1 482 GLY n 
1 483 TRP n 
1 484 SER n 
1 485 LEU n 
1 486 ARG n 
1 487 GLU n 
1 488 THR n 
1 489 ALA n 
1 490 CYS n 
1 491 LEU n 
1 492 GLY n 
1 493 LYS n 
1 494 SER n 
1 495 TYR n 
1 496 ALA n 
1 497 GLN n 
1 498 MET n 
1 499 TRP n 
1 500 SER n 
1 501 LEU n 
1 502 MET n 
1 503 TYR n 
1 504 PHE n 
1 505 HIS n 
1 506 ARG n 
1 507 ARG n 
1 508 ASP n 
1 509 LEU n 
1 510 ARG n 
1 511 LEU n 
1 512 ALA n 
1 513 ALA n 
1 514 ASN n 
1 515 ALA n 
1 516 ILE n 
1 517 CYS n 
1 518 SER n 
1 519 ALA n 
1 520 VAL n 
1 521 PRO n 
1 522 SER n 
1 523 HIS n 
1 524 TRP n 
1 525 VAL n 
1 526 PRO n 
1 527 THR n 
1 528 SER n 
1 529 ARG n 
1 530 THR n 
1 531 THR n 
1 532 TRP n 
1 533 SER n 
1 534 ILE n 
1 535 HIS n 
1 536 ALA n 
1 537 THR n 
1 538 HIS n 
1 539 GLU n 
1 540 TRP n 
1 541 MET n 
1 542 THR n 
1 543 THR n 
1 544 GLU n 
1 545 ASP n 
1 546 MET n 
1 547 LEU n 
1 548 THR n 
1 549 VAL n 
1 550 TRP n 
1 551 ASN n 
1 552 ARG n 
1 553 VAL n 
1 554 TRP n 
1 555 ILE n 
1 556 GLN n 
1 557 GLU n 
1 558 ASN n 
1 559 PRO n 
1 560 TRP n 
1 561 MET n 
1 562 GLU n 
1 563 ASP n 
1 564 LYS n 
1 565 THR n 
1 566 PRO n 
1 567 VAL n 
1 568 GLU n 
1 569 SER n 
1 570 TRP n 
1 571 GLU n 
1 572 GLU n 
1 573 ILE n 
1 574 PRO n 
1 575 TYR n 
1 576 LEU n 
1 577 GLY n 
1 578 LYS n 
1 579 ARG n 
1 580 GLU n 
1 581 ASP n 
1 582 GLN n 
1 583 TRP n 
1 584 CYS n 
1 585 GLY n 
1 586 SER n 
1 587 LEU n 
1 588 ILE n 
1 589 GLY n 
1 590 LEU n 
1 591 THR n 
1 592 SER n 
1 593 ARG n 
1 594 ALA n 
1 595 THR n 
1 596 TRP n 
1 597 ALA n 
1 598 LYS n 
1 599 ASN n 
1 600 ILE n 
1 601 GLN n 
1 602 THR n 
1 603 ALA n 
1 604 ILE n 
1 605 ASN n 
1 606 GLN n 
1 607 VAL n 
1 608 ARG n 
1 609 SER n 
1 610 LEU n 
1 611 ILE n 
1 612 GLY n 
1 613 ASN n 
1 614 GLU n 
1 615 GLU n 
1 616 TYR n 
1 617 THR n 
1 618 ASP n 
1 619 TYR n 
1 620 MET n 
1 621 PRO n 
1 622 SER n 
1 623 MET n 
1 624 LYS n 
1 625 ARG n 
1 626 PHE n 
1 627 ARG n 
1 628 ARG n 
1 629 GLU n 
1 630 GLU n 
1 631 GLU n 
1 632 GLU n 
1 633 ALA n 
1 634 GLY n 
1 635 VAL n 
1 636 LEU n 
1 637 TRP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   637 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'dengue virus type 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     11060 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                           ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                          ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                        ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                   ? 'C4 H7 N O4'     133.103 
CL  non-polymer         . 'CHLORIDE ION'                                    ? 'Cl -1'          35.453  
CYS 'L-peptide linking' y CYSTEINE                                          ? 'C3 H7 N O2 S'   121.158 
DMS non-polymer         . 'DIMETHYL SULFOXIDE'                              ? 'C2 H6 O S'      78.133  
GLN 'L-peptide linking' y GLUTAMINE                                         ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                   ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                           ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                         ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                             ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                        ? 'C6 H13 N O2'    131.173 
JGP non-polymer         . '(azepan-1-yl)(2H-1,3-benzodioxol-5-yl)methanone' ? 'C14 H17 N O3'   247.290 
LEU 'L-peptide linking' y LEUCINE                                           ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                            ? 'C6 H15 N2 O2 1' 147.195 
MES non-polymer         . '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'            ? 'C6 H13 N O4 S'  195.237 
MET 'L-peptide linking' y METHIONINE                                        ? 'C5 H11 N O2 S'  149.211 
PEG non-polymer         . 'DI(HYDROXYETHYL)ETHER'                           ? 'C4 H10 O3'      106.120 
PHE 'L-peptide linking' y PHENYLALANINE                                     ? 'C9 H11 N O2'    165.189 
PO4 non-polymer         . 'PHOSPHATE ION'                                   ? 'O4 P -3'        94.971  
PRO 'L-peptide linking' y PROLINE                                           ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                            ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                         ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                        ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                          ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                                            ? 'C5 H11 N O2'    117.146 
ZN  non-polymer         . 'ZINC ION'                                        ? 'Zn 2'           65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   264 ?   ?   ?   A . n 
A 1 2   PRO 2   265 ?   ?   ?   A . n 
A 1 3   GLY 3   266 ?   ?   ?   A . n 
A 1 4   ILE 4   267 ?   ?   ?   A . n 
A 1 5   GLU 5   268 ?   ?   ?   A . n 
A 1 6   SER 6   269 ?   ?   ?   A . n 
A 1 7   GLU 7   270 ?   ?   ?   A . n 
A 1 8   THR 8   271 ?   ?   ?   A . n 
A 1 9   PRO 9   272 ?   ?   ?   A . n 
A 1 10  ASN 10  273 273 ASN ASN A . n 
A 1 11  LEU 11  274 274 LEU LEU A . n 
A 1 12  ASP 12  275 275 ASP ASP A . n 
A 1 13  ILE 13  276 276 ILE ILE A . n 
A 1 14  ILE 14  277 277 ILE ILE A . n 
A 1 15  GLY 15  278 278 GLY GLY A . n 
A 1 16  LYS 16  279 279 LYS LYS A . n 
A 1 17  ARG 17  280 280 ARG ARG A . n 
A 1 18  ILE 18  281 281 ILE ILE A . n 
A 1 19  GLU 19  282 282 GLU GLU A . n 
A 1 20  LYS 20  283 283 LYS LYS A . n 
A 1 21  ILE 21  284 284 ILE ILE A . n 
A 1 22  LYS 22  285 285 LYS LYS A . n 
A 1 23  GLN 23  286 286 GLN GLN A . n 
A 1 24  GLU 24  287 287 GLU GLU A . n 
A 1 25  HIS 25  288 288 HIS HIS A . n 
A 1 26  GLU 26  289 289 GLU GLU A . n 
A 1 27  THR 27  290 290 THR THR A . n 
A 1 28  SER 28  291 291 SER SER A . n 
A 1 29  TRP 29  292 292 TRP TRP A . n 
A 1 30  HIS 30  293 293 HIS HIS A . n 
A 1 31  TYR 31  294 294 TYR TYR A . n 
A 1 32  ASP 32  295 295 ASP ASP A . n 
A 1 33  GLN 33  296 296 GLN GLN A . n 
A 1 34  ASP 34  297 297 ASP ASP A . n 
A 1 35  HIS 35  298 298 HIS HIS A . n 
A 1 36  PRO 36  299 299 PRO PRO A . n 
A 1 37  TYR 37  300 300 TYR TYR A . n 
A 1 38  LYS 38  301 301 LYS LYS A . n 
A 1 39  THR 39  302 302 THR THR A . n 
A 1 40  TRP 40  303 303 TRP TRP A . n 
A 1 41  ALA 41  304 304 ALA ALA A . n 
A 1 42  TYR 42  305 305 TYR TYR A . n 
A 1 43  HIS 43  306 306 HIS HIS A . n 
A 1 44  GLY 44  307 307 GLY GLY A . n 
A 1 45  SER 45  308 308 SER SER A . n 
A 1 46  TYR 46  309 309 TYR TYR A . n 
A 1 47  GLU 47  310 310 GLU GLU A . n 
A 1 48  THR 48  311 311 THR THR A . n 
A 1 49  LYS 49  312 312 LYS LYS A . n 
A 1 50  GLN 50  313 ?   ?   ?   A . n 
A 1 51  THR 51  314 ?   ?   ?   A . n 
A 1 52  GLY 52  315 ?   ?   ?   A . n 
A 1 53  SER 53  316 ?   ?   ?   A . n 
A 1 54  ALA 54  317 ?   ?   ?   A . n 
A 1 55  SER 55  318 ?   ?   ?   A . n 
A 1 56  SER 56  319 319 SER SER A . n 
A 1 57  MET 57  320 320 MET MET A . n 
A 1 58  VAL 58  321 321 VAL VAL A . n 
A 1 59  ASN 59  322 322 ASN ASN A . n 
A 1 60  GLY 60  323 323 GLY GLY A . n 
A 1 61  VAL 61  324 324 VAL VAL A . n 
A 1 62  VAL 62  325 325 VAL VAL A . n 
A 1 63  ARG 63  326 326 ARG ARG A . n 
A 1 64  LEU 64  327 327 LEU LEU A . n 
A 1 65  LEU 65  328 328 LEU LEU A . n 
A 1 66  THR 66  329 329 THR THR A . n 
A 1 67  LYS 67  330 330 LYS LYS A . n 
A 1 68  PRO 68  331 331 PRO PRO A . n 
A 1 69  TRP 69  332 332 TRP TRP A . n 
A 1 70  ASP 70  333 333 ASP ASP A . n 
A 1 71  ILE 71  334 334 ILE ILE A . n 
A 1 72  ILE 72  335 335 ILE ILE A . n 
A 1 73  PRO 73  336 336 PRO PRO A . n 
A 1 74  MET 74  337 337 MET MET A . n 
A 1 75  VAL 75  338 338 VAL VAL A . n 
A 1 76  THR 76  339 339 THR THR A . n 
A 1 77  GLN 77  340 340 GLN GLN A . n 
A 1 78  MET 78  341 341 MET MET A . n 
A 1 79  ALA 79  342 342 ALA ALA A . n 
A 1 80  MET 80  343 343 MET MET A . n 
A 1 81  THR 81  344 344 THR GLY A . n 
A 1 82  ASP 82  345 ?   ?   ?   A . n 
A 1 83  THR 83  346 ?   ?   ?   A . n 
A 1 84  THR 84  347 ?   ?   ?   A . n 
A 1 85  PRO 85  348 ?   ?   ?   A . n 
A 1 86  PHE 86  349 ?   ?   ?   A . n 
A 1 87  GLY 87  350 ?   ?   ?   A . n 
A 1 88  GLN 88  351 ?   ?   ?   A . n 
A 1 89  GLN 89  352 ?   ?   ?   A . n 
A 1 90  ARG 90  353 ?   ?   ?   A . n 
A 1 91  VAL 91  354 ?   ?   ?   A . n 
A 1 92  PHE 92  355 ?   ?   ?   A . n 
A 1 93  LYS 93  356 ?   ?   ?   A . n 
A 1 94  GLU 94  357 357 GLU GLU A . n 
A 1 95  LYS 95  358 358 LYS LYS A . n 
A 1 96  VAL 96  359 359 VAL VAL A . n 
A 1 97  ASP 97  360 360 ASP ASP A . n 
A 1 98  THR 98  361 361 THR THR A . n 
A 1 99  ARG 99  362 362 ARG ARG A . n 
A 1 100 THR 100 363 363 THR THR A . n 
A 1 101 GLN 101 364 364 GLN GLN A . n 
A 1 102 GLU 102 365 365 GLU GLU A . n 
A 1 103 PRO 103 366 366 PRO PRO A . n 
A 1 104 LYS 104 367 367 LYS LYS A . n 
A 1 105 GLU 105 368 368 GLU GLU A . n 
A 1 106 GLY 106 369 369 GLY GLY A . n 
A 1 107 THR 107 370 370 THR THR A . n 
A 1 108 LYS 108 371 371 LYS LYS A . n 
A 1 109 LYS 109 372 372 LYS LYS A . n 
A 1 110 LEU 110 373 373 LEU LEU A . n 
A 1 111 MET 111 374 374 MET MET A . n 
A 1 112 LYS 112 375 375 LYS LYS A . n 
A 1 113 ILE 113 376 376 ILE ILE A . n 
A 1 114 THR 114 377 377 THR THR A . n 
A 1 115 ALA 115 378 378 ALA ALA A . n 
A 1 116 GLU 116 379 379 GLU GLU A . n 
A 1 117 TRP 117 380 380 TRP TRP A . n 
A 1 118 LEU 118 381 381 LEU LEU A . n 
A 1 119 TRP 119 382 382 TRP TRP A . n 
A 1 120 LYS 120 383 383 LYS LYS A . n 
A 1 121 GLU 121 384 384 GLU GLU A . n 
A 1 122 LEU 122 385 385 LEU LEU A . n 
A 1 123 GLY 123 386 386 GLY GLY A . n 
A 1 124 LYS 124 387 387 LYS LYS A . n 
A 1 125 LYS 125 388 388 LYS LYS A . n 
A 1 126 LYS 126 389 389 LYS LYS A . n 
A 1 127 THR 127 390 390 THR THR A . n 
A 1 128 PRO 128 391 391 PRO PRO A . n 
A 1 129 ARG 129 392 392 ARG ARG A . n 
A 1 130 MET 130 393 393 MET MET A . n 
A 1 131 CYS 131 394 394 CYS CYS A . n 
A 1 132 THR 132 395 395 THR THR A . n 
A 1 133 ARG 133 396 396 ARG ARG A . n 
A 1 134 GLU 134 397 397 GLU GLU A . n 
A 1 135 GLU 135 398 398 GLU GLU A . n 
A 1 136 PHE 136 399 399 PHE PHE A . n 
A 1 137 THR 137 400 400 THR THR A . n 
A 1 138 ARG 138 401 401 ARG ARG A . n 
A 1 139 LYS 139 402 402 LYS LYS A . n 
A 1 140 VAL 140 403 403 VAL VAL A . n 
A 1 141 ARG 141 404 404 ARG ARG A . n 
A 1 142 SER 142 405 405 SER SER A . n 
A 1 143 ASN 143 406 406 ASN ASN A . n 
A 1 144 ALA 144 407 ?   ?   ?   A . n 
A 1 145 ALA 145 408 ?   ?   ?   A . n 
A 1 146 LEU 146 409 ?   ?   ?   A . n 
A 1 147 GLY 147 410 ?   ?   ?   A . n 
A 1 148 ALA 148 411 ?   ?   ?   A . n 
A 1 149 ILE 149 412 ?   ?   ?   A . n 
A 1 150 PHE 150 413 ?   ?   ?   A . n 
A 1 151 THR 151 414 ?   ?   ?   A . n 
A 1 152 ASP 152 415 ?   ?   ?   A . n 
A 1 153 GLU 153 416 ?   ?   ?   A . n 
A 1 154 ASN 154 417 ?   ?   ?   A . n 
A 1 155 LYS 155 418 ?   ?   ?   A . n 
A 1 156 TRP 156 419 419 TRP TRP A . n 
A 1 157 LYS 157 420 420 LYS LYS A . n 
A 1 158 SER 158 421 421 SER SER A . n 
A 1 159 ALA 159 422 422 ALA ALA A . n 
A 1 160 ARG 160 423 423 ARG ARG A . n 
A 1 161 GLU 161 424 424 GLU GLU A . n 
A 1 162 ALA 162 425 425 ALA ALA A . n 
A 1 163 VAL 163 426 426 VAL VAL A . n 
A 1 164 GLU 164 427 427 GLU GLU A . n 
A 1 165 ASP 165 428 428 ASP ASP A . n 
A 1 166 SER 166 429 429 SER SER A . n 
A 1 167 GLY 167 430 430 GLY GLY A . n 
A 1 168 PHE 168 431 431 PHE PHE A . n 
A 1 169 TRP 169 432 432 TRP TRP A . n 
A 1 170 GLU 170 433 433 GLU GLU A . n 
A 1 171 LEU 171 434 434 LEU LEU A . n 
A 1 172 VAL 172 435 435 VAL VAL A . n 
A 1 173 ASP 173 436 436 ASP ASP A . n 
A 1 174 LYS 174 437 437 LYS LYS A . n 
A 1 175 GLU 175 438 438 GLU GLU A . n 
A 1 176 ARG 176 439 439 ARG ARG A . n 
A 1 177 ASN 177 440 440 ASN ASN A . n 
A 1 178 LEU 178 441 441 LEU LEU A . n 
A 1 179 HIS 179 442 442 HIS HIS A . n 
A 1 180 LEU 180 443 443 LEU LEU A . n 
A 1 181 GLU 181 444 444 GLU GLU A . n 
A 1 182 GLY 182 445 445 GLY GLY A . n 
A 1 183 LYS 183 446 446 LYS LYS A . n 
A 1 184 CYS 184 447 447 CYS CYS A . n 
A 1 185 GLU 185 448 448 GLU GLU A . n 
A 1 186 THR 186 449 449 THR THR A . n 
A 1 187 CYS 187 450 450 CYS CYS A . n 
A 1 188 VAL 188 451 451 VAL VAL A . n 
A 1 189 TYR 189 452 452 TYR TYR A . n 
A 1 190 ASN 190 453 453 ASN ASN A . n 
A 1 191 MET 191 454 454 MET MET A . n 
A 1 192 MET 192 455 455 MET MET A . n 
A 1 193 GLY 193 456 ?   ?   ?   A . n 
A 1 194 LYS 194 457 ?   ?   ?   A . n 
A 1 195 ARG 195 458 ?   ?   ?   A . n 
A 1 196 GLU 196 459 ?   ?   ?   A . n 
A 1 197 LYS 197 460 ?   ?   ?   A . n 
A 1 198 LYS 198 461 ?   ?   ?   A . n 
A 1 199 LEU 199 462 ?   ?   ?   A . n 
A 1 200 GLY 200 463 ?   ?   ?   A . n 
A 1 201 GLU 201 464 ?   ?   ?   A . n 
A 1 202 PHE 202 465 ?   ?   ?   A . n 
A 1 203 GLY 203 466 ?   ?   ?   A . n 
A 1 204 LYS 204 467 ?   ?   ?   A . n 
A 1 205 ALA 205 468 ?   ?   ?   A . n 
A 1 206 LYS 206 469 ?   ?   ?   A . n 
A 1 207 GLY 207 470 ?   ?   ?   A . n 
A 1 208 SER 208 471 ?   ?   ?   A . n 
A 1 209 ARG 209 472 ?   ?   ?   A . n 
A 1 210 ALA 210 473 ?   ?   ?   A . n 
A 1 211 ILE 211 474 474 ILE ILE A . n 
A 1 212 TRP 212 475 475 TRP TRP A . n 
A 1 213 TYR 213 476 476 TYR TYR A . n 
A 1 214 MET 214 477 477 MET MET A . n 
A 1 215 TRP 215 478 478 TRP TRP A . n 
A 1 216 LEU 216 479 479 LEU LEU A . n 
A 1 217 GLY 217 480 480 GLY GLY A . n 
A 1 218 ALA 218 481 481 ALA ALA A . n 
A 1 219 ARG 219 482 482 ARG ARG A . n 
A 1 220 PHE 220 483 483 PHE PHE A . n 
A 1 221 LEU 221 484 484 LEU LEU A . n 
A 1 222 GLU 222 485 485 GLU GLU A . n 
A 1 223 PHE 223 486 486 PHE PHE A . n 
A 1 224 GLU 224 487 487 GLU GLU A . n 
A 1 225 ALA 225 488 488 ALA ALA A . n 
A 1 226 LEU 226 489 489 LEU LEU A . n 
A 1 227 GLY 227 490 490 GLY GLY A . n 
A 1 228 PHE 228 491 491 PHE PHE A . n 
A 1 229 LEU 229 492 492 LEU LEU A . n 
A 1 230 ASN 230 493 493 ASN ASN A . n 
A 1 231 GLU 231 494 494 GLU GLU A . n 
A 1 232 ASP 232 495 495 ASP ASP A . n 
A 1 233 HIS 233 496 496 HIS HIS A . n 
A 1 234 TRP 234 497 497 TRP TRP A . n 
A 1 235 PHE 235 498 498 PHE PHE A . n 
A 1 236 SER 236 499 499 SER SER A . n 
A 1 237 ARG 237 500 500 ARG ARG A . n 
A 1 238 GLU 238 501 501 GLU GLU A . n 
A 1 239 ASN 239 502 502 ASN ASN A . n 
A 1 240 SER 240 503 503 SER SER A . n 
A 1 241 LEU 241 504 504 LEU LEU A . n 
A 1 242 SER 242 505 505 SER SER A . n 
A 1 243 GLY 243 506 506 GLY GLY A . n 
A 1 244 VAL 244 507 507 VAL VAL A . n 
A 1 245 GLU 245 508 508 GLU GLU A . n 
A 1 246 GLY 246 509 509 GLY GLY A . n 
A 1 247 GLU 247 510 510 GLU GLU A . n 
A 1 248 GLY 248 511 511 GLY GLY A . n 
A 1 249 LEU 249 512 512 LEU LEU A . n 
A 1 250 HIS 250 513 513 HIS HIS A . n 
A 1 251 LYS 251 514 514 LYS LYS A . n 
A 1 252 LEU 252 515 515 LEU LEU A . n 
A 1 253 GLY 253 516 516 GLY GLY A . n 
A 1 254 TYR 254 517 517 TYR TYR A . n 
A 1 255 ILE 255 518 518 ILE ILE A . n 
A 1 256 LEU 256 519 519 LEU LEU A . n 
A 1 257 ARG 257 520 520 ARG ARG A . n 
A 1 258 ASP 258 521 521 ASP ASP A . n 
A 1 259 VAL 259 522 522 VAL VAL A . n 
A 1 260 SER 260 523 523 SER SER A . n 
A 1 261 LYS 261 524 524 LYS LYS A . n 
A 1 262 LYS 262 525 525 LYS LYS A . n 
A 1 263 GLU 263 526 526 GLU GLU A . n 
A 1 264 GLY 264 527 527 GLY GLY A . n 
A 1 265 GLY 265 528 528 GLY GLY A . n 
A 1 266 ALA 266 529 529 ALA ALA A . n 
A 1 267 MET 267 530 530 MET MET A . n 
A 1 268 TYR 268 531 531 TYR TYR A . n 
A 1 269 ALA 269 532 532 ALA ALA A . n 
A 1 270 ASP 270 533 533 ASP ASP A . n 
A 1 271 ASP 271 534 534 ASP ASP A . n 
A 1 272 THR 272 535 535 THR THR A . n 
A 1 273 ALA 273 536 536 ALA ALA A . n 
A 1 274 GLY 274 537 537 GLY GLY A . n 
A 1 275 TRP 275 538 538 TRP TRP A . n 
A 1 276 ASP 276 539 539 ASP ASP A . n 
A 1 277 THR 277 540 540 THR THR A . n 
A 1 278 ARG 278 541 541 ARG ARG A . n 
A 1 279 ILE 279 542 542 ILE ILE A . n 
A 1 280 THR 280 543 543 THR THR A . n 
A 1 281 LEU 281 544 544 LEU LEU A . n 
A 1 282 GLU 282 545 545 GLU GLU A . n 
A 1 283 ASP 283 546 546 ASP ASP A . n 
A 1 284 LEU 284 547 547 LEU LEU A . n 
A 1 285 LYS 285 548 548 LYS LYS A . n 
A 1 286 ASN 286 549 549 ASN ASN A . n 
A 1 287 GLU 287 550 550 GLU GLU A . n 
A 1 288 GLU 288 551 551 GLU GLU A . n 
A 1 289 MET 289 552 552 MET MET A . n 
A 1 290 VAL 290 553 553 VAL VAL A . n 
A 1 291 THR 291 554 554 THR THR A . n 
A 1 292 ASN 292 555 555 ASN ASN A . n 
A 1 293 HIS 293 556 556 HIS HIS A . n 
A 1 294 MET 294 557 557 MET MET A . n 
A 1 295 GLU 295 558 558 GLU GLU A . n 
A 1 296 GLY 296 559 559 GLY GLY A . n 
A 1 297 GLU 297 560 560 GLU GLU A . n 
A 1 298 HIS 298 561 561 HIS HIS A . n 
A 1 299 LYS 299 562 562 LYS LYS A . n 
A 1 300 LYS 300 563 563 LYS LYS A . n 
A 1 301 LEU 301 564 564 LEU LEU A . n 
A 1 302 ALA 302 565 565 ALA ALA A . n 
A 1 303 GLU 303 566 566 GLU GLU A . n 
A 1 304 ALA 304 567 567 ALA ALA A . n 
A 1 305 ILE 305 568 568 ILE ILE A . n 
A 1 306 PHE 306 569 569 PHE PHE A . n 
A 1 307 LYS 307 570 570 LYS LYS A . n 
A 1 308 LEU 308 571 571 LEU LEU A . n 
A 1 309 THR 309 572 572 THR THR A . n 
A 1 310 TYR 310 573 573 TYR TYR A . n 
A 1 311 GLN 311 574 574 GLN GLN A . n 
A 1 312 ASN 312 575 575 ASN ASN A . n 
A 1 313 LYS 313 576 576 LYS LYS A . n 
A 1 314 VAL 314 577 577 VAL VAL A . n 
A 1 315 VAL 315 578 578 VAL VAL A . n 
A 1 316 ARG 316 579 579 ARG ARG A . n 
A 1 317 VAL 317 580 580 VAL VAL A . n 
A 1 318 GLN 318 581 581 GLN GLN A . n 
A 1 319 ARG 319 582 582 ARG ARG A . n 
A 1 320 PRO 320 583 583 PRO PRO A . n 
A 1 321 THR 321 584 584 THR THR A . n 
A 1 322 PRO 322 585 ?   ?   ?   A . n 
A 1 323 ARG 323 586 ?   ?   ?   A . n 
A 1 324 GLY 324 587 ?   ?   ?   A . n 
A 1 325 THR 325 588 588 THR THR A . n 
A 1 326 VAL 326 589 589 VAL VAL A . n 
A 1 327 MET 327 590 590 MET MET A . n 
A 1 328 ASP 328 591 591 ASP ASP A . n 
A 1 329 ILE 329 592 592 ILE ILE A . n 
A 1 330 ILE 330 593 593 ILE ILE A . n 
A 1 331 SER 331 594 594 SER SER A . n 
A 1 332 ARG 332 595 595 ARG ARG A . n 
A 1 333 ARG 333 596 596 ARG ARG A . n 
A 1 334 ASP 334 597 597 ASP ASP A . n 
A 1 335 GLN 335 598 598 GLN GLN A . n 
A 1 336 ARG 336 599 599 ARG ARG A . n 
A 1 337 GLY 337 600 600 GLY GLY A . n 
A 1 338 SER 338 601 601 SER SER A . n 
A 1 339 GLY 339 602 602 GLY GLY A . n 
A 1 340 GLN 340 603 603 GLN GLN A . n 
A 1 341 VAL 341 604 604 VAL VAL A . n 
A 1 342 VAL 342 605 605 VAL VAL A . n 
A 1 343 THR 343 606 606 THR THR A . n 
A 1 344 TYR 344 607 607 TYR TYR A . n 
A 1 345 GLY 345 608 608 GLY GLY A . n 
A 1 346 LEU 346 609 609 LEU LEU A . n 
A 1 347 ASN 347 610 610 ASN ASN A . n 
A 1 348 THR 348 611 611 THR THR A . n 
A 1 349 PHE 349 612 612 PHE PHE A . n 
A 1 350 THR 350 613 613 THR THR A . n 
A 1 351 ASN 351 614 614 ASN ASN A . n 
A 1 352 MET 352 615 615 MET MET A . n 
A 1 353 GLU 353 616 616 GLU GLU A . n 
A 1 354 ALA 354 617 617 ALA ALA A . n 
A 1 355 GLN 355 618 618 GLN GLN A . n 
A 1 356 LEU 356 619 619 LEU LEU A . n 
A 1 357 ILE 357 620 620 ILE ILE A . n 
A 1 358 ARG 358 621 621 ARG ARG A . n 
A 1 359 GLN 359 622 622 GLN GLN A . n 
A 1 360 MET 360 623 623 MET MET A . n 
A 1 361 GLU 361 624 624 GLU GLU A . n 
A 1 362 GLY 362 625 625 GLY GLY A . n 
A 1 363 GLU 363 626 626 GLU GLU A . n 
A 1 364 GLY 364 627 627 GLY GLY A . n 
A 1 365 VAL 365 628 628 VAL VAL A . n 
A 1 366 PHE 366 629 629 PHE PHE A . n 
A 1 367 LYS 367 630 630 LYS LYS A . n 
A 1 368 SER 368 631 631 SER SER A . n 
A 1 369 ILE 369 632 632 ILE ILE A . n 
A 1 370 GLN 370 633 633 GLN GLN A . n 
A 1 371 HIS 371 634 634 HIS HIS A . n 
A 1 372 LEU 372 635 635 LEU LEU A . n 
A 1 373 THR 373 636 636 THR THR A . n 
A 1 374 VAL 374 637 637 VAL VAL A . n 
A 1 375 THR 375 638 638 THR THR A . n 
A 1 376 GLU 376 639 639 GLU GLU A . n 
A 1 377 GLU 377 640 640 GLU GLU A . n 
A 1 378 ILE 378 641 641 ILE ILE A . n 
A 1 379 ALA 379 642 642 ALA ALA A . n 
A 1 380 VAL 380 643 643 VAL VAL A . n 
A 1 381 LYS 381 644 644 LYS LYS A . n 
A 1 382 ASN 382 645 645 ASN ASN A . n 
A 1 383 TRP 383 646 646 TRP TRP A . n 
A 1 384 LEU 384 647 647 LEU LEU A . n 
A 1 385 VAL 385 648 648 VAL VAL A . n 
A 1 386 ARG 386 649 649 ARG ARG A . n 
A 1 387 VAL 387 650 650 VAL VAL A . n 
A 1 388 GLY 388 651 651 GLY GLY A . n 
A 1 389 ARG 389 652 652 ARG ARG A . n 
A 1 390 GLU 390 653 653 GLU GLU A . n 
A 1 391 ARG 391 654 654 ARG ARG A . n 
A 1 392 LEU 392 655 655 LEU LEU A . n 
A 1 393 SER 393 656 656 SER SER A . n 
A 1 394 ARG 394 657 657 ARG ARG A . n 
A 1 395 MET 395 658 658 MET MET A . n 
A 1 396 ALA 396 659 659 ALA ALA A . n 
A 1 397 ILE 397 660 660 ILE ILE A . n 
A 1 398 SER 398 661 661 SER SER A . n 
A 1 399 GLY 399 662 662 GLY GLY A . n 
A 1 400 ASP 400 663 663 ASP ASP A . n 
A 1 401 ASP 401 664 664 ASP ASP A . n 
A 1 402 CYS 402 665 665 CYS CYS A . n 
A 1 403 VAL 403 666 666 VAL VAL A . n 
A 1 404 VAL 404 667 667 VAL VAL A . n 
A 1 405 LYS 405 668 668 LYS LYS A . n 
A 1 406 PRO 406 669 669 PRO PRO A . n 
A 1 407 LEU 407 670 670 LEU LEU A . n 
A 1 408 ASP 408 671 671 ASP ASP A . n 
A 1 409 ASP 409 672 672 ASP ASP A . n 
A 1 410 ARG 410 673 673 ARG ARG A . n 
A 1 411 PHE 411 674 674 PHE PHE A . n 
A 1 412 ALA 412 675 675 ALA ALA A . n 
A 1 413 SER 413 676 676 SER SER A . n 
A 1 414 ALA 414 677 677 ALA ALA A . n 
A 1 415 LEU 415 678 678 LEU LEU A . n 
A 1 416 THR 416 679 679 THR THR A . n 
A 1 417 ALA 417 680 680 ALA ALA A . n 
A 1 418 LEU 418 681 681 LEU LEU A . n 
A 1 419 ASN 419 682 682 ASN ASN A . n 
A 1 420 ASP 420 683 683 ASP ASP A . n 
A 1 421 MET 421 684 684 MET MET A . n 
A 1 422 GLY 422 685 685 GLY GLY A . n 
A 1 423 LYS 423 686 686 LYS LYS A . n 
A 1 424 VAL 424 687 687 VAL VAL A . n 
A 1 425 ARG 425 688 688 ARG ARG A . n 
A 1 426 LYS 426 689 689 LYS LYS A . n 
A 1 427 ASP 427 690 690 ASP ASP A . n 
A 1 428 ILE 428 691 691 ILE ILE A . n 
A 1 429 GLN 429 692 692 GLN GLN A . n 
A 1 430 GLN 430 693 693 GLN GLN A . n 
A 1 431 TRP 431 694 694 TRP TRP A . n 
A 1 432 GLU 432 695 695 GLU GLU A . n 
A 1 433 PRO 433 696 696 PRO PRO A . n 
A 1 434 SER 434 697 697 SER SER A . n 
A 1 435 ARG 435 698 698 ARG ARG A . n 
A 1 436 GLY 436 699 699 GLY GLY A . n 
A 1 437 TRP 437 700 700 TRP TRP A . n 
A 1 438 ASN 438 701 701 ASN ASN A . n 
A 1 439 ASP 439 702 702 ASP ASP A . n 
A 1 440 TRP 440 703 703 TRP TRP A . n 
A 1 441 THR 441 704 704 THR THR A . n 
A 1 442 GLN 442 705 705 GLN GLN A . n 
A 1 443 VAL 443 706 706 VAL VAL A . n 
A 1 444 PRO 444 707 707 PRO PRO A . n 
A 1 445 PHE 445 708 708 PHE PHE A . n 
A 1 446 CYS 446 709 709 CYS CYS A . n 
A 1 447 SER 447 710 710 SER SER A . n 
A 1 448 HIS 448 711 711 HIS HIS A . n 
A 1 449 HIS 449 712 712 HIS HIS A . n 
A 1 450 PHE 450 713 713 PHE PHE A . n 
A 1 451 HIS 451 714 714 HIS HIS A . n 
A 1 452 GLU 452 715 715 GLU GLU A . n 
A 1 453 LEU 453 716 716 LEU LEU A . n 
A 1 454 ILE 454 717 717 ILE ILE A . n 
A 1 455 MET 455 718 718 MET MET A . n 
A 1 456 LYS 456 719 719 LYS LYS A . n 
A 1 457 ASP 457 720 720 ASP ASP A . n 
A 1 458 GLY 458 721 721 GLY GLY A . n 
A 1 459 ARG 459 722 722 ARG ARG A . n 
A 1 460 VAL 460 723 723 VAL VAL A . n 
A 1 461 LEU 461 724 724 LEU LEU A . n 
A 1 462 VAL 462 725 725 VAL VAL A . n 
A 1 463 VAL 463 726 726 VAL VAL A . n 
A 1 464 PRO 464 727 727 PRO PRO A . n 
A 1 465 CYS 465 728 728 CYS CYS A . n 
A 1 466 ARG 466 729 729 ARG ARG A . n 
A 1 467 ASN 467 730 730 ASN ASN A . n 
A 1 468 GLN 468 731 731 GLN GLN A . n 
A 1 469 ASP 469 732 732 ASP ASP A . n 
A 1 470 GLU 470 733 733 GLU GLU A . n 
A 1 471 LEU 471 734 734 LEU LEU A . n 
A 1 472 ILE 472 735 735 ILE ILE A . n 
A 1 473 GLY 473 736 736 GLY GLY A . n 
A 1 474 ARG 474 737 737 ARG ARG A . n 
A 1 475 ALA 475 738 738 ALA ALA A . n 
A 1 476 ARG 476 739 739 ARG ARG A . n 
A 1 477 ILE 477 740 740 ILE ILE A . n 
A 1 478 SER 478 741 741 SER SER A . n 
A 1 479 GLN 479 742 742 GLN GLN A . n 
A 1 480 GLY 480 743 743 GLY GLY A . n 
A 1 481 ALA 481 744 744 ALA ALA A . n 
A 1 482 GLY 482 745 745 GLY GLY A . n 
A 1 483 TRP 483 746 746 TRP TRP A . n 
A 1 484 SER 484 747 747 SER SER A . n 
A 1 485 LEU 485 748 748 LEU LEU A . n 
A 1 486 ARG 486 749 749 ARG ARG A . n 
A 1 487 GLU 487 750 750 GLU GLU A . n 
A 1 488 THR 488 751 751 THR THR A . n 
A 1 489 ALA 489 752 752 ALA ALA A . n 
A 1 490 CYS 490 753 753 CYS CYS A . n 
A 1 491 LEU 491 754 754 LEU LEU A . n 
A 1 492 GLY 492 755 755 GLY GLY A . n 
A 1 493 LYS 493 756 756 LYS LYS A . n 
A 1 494 SER 494 757 757 SER SER A . n 
A 1 495 TYR 495 758 758 TYR TYR A . n 
A 1 496 ALA 496 759 759 ALA ALA A . n 
A 1 497 GLN 497 760 760 GLN GLN A . n 
A 1 498 MET 498 761 761 MET MET A . n 
A 1 499 TRP 499 762 762 TRP TRP A . n 
A 1 500 SER 500 763 763 SER SER A . n 
A 1 501 LEU 501 764 764 LEU LEU A . n 
A 1 502 MET 502 765 765 MET MET A . n 
A 1 503 TYR 503 766 766 TYR TYR A . n 
A 1 504 PHE 504 767 767 PHE PHE A . n 
A 1 505 HIS 505 768 768 HIS HIS A . n 
A 1 506 ARG 506 769 769 ARG ARG A . n 
A 1 507 ARG 507 770 770 ARG ARG A . n 
A 1 508 ASP 508 771 771 ASP ASP A . n 
A 1 509 LEU 509 772 772 LEU LEU A . n 
A 1 510 ARG 510 773 773 ARG ARG A . n 
A 1 511 LEU 511 774 774 LEU LEU A . n 
A 1 512 ALA 512 775 775 ALA ALA A . n 
A 1 513 ALA 513 776 776 ALA ALA A . n 
A 1 514 ASN 514 777 777 ASN ASN A . n 
A 1 515 ALA 515 778 778 ALA ALA A . n 
A 1 516 ILE 516 779 779 ILE ILE A . n 
A 1 517 CYS 517 780 780 CYS CYS A . n 
A 1 518 SER 518 781 781 SER SER A . n 
A 1 519 ALA 519 782 782 ALA ALA A . n 
A 1 520 VAL 520 783 783 VAL VAL A . n 
A 1 521 PRO 521 784 784 PRO PRO A . n 
A 1 522 SER 522 785 785 SER SER A . n 
A 1 523 HIS 523 786 786 HIS HIS A . n 
A 1 524 TRP 524 787 787 TRP TRP A . n 
A 1 525 VAL 525 788 788 VAL VAL A . n 
A 1 526 PRO 526 789 789 PRO PRO A . n 
A 1 527 THR 527 790 790 THR THR A . n 
A 1 528 SER 528 791 791 SER SER A . n 
A 1 529 ARG 529 792 ?   ?   ?   A . n 
A 1 530 THR 530 793 ?   ?   ?   A . n 
A 1 531 THR 531 794 ?   ?   ?   A . n 
A 1 532 TRP 532 795 ?   ?   ?   A . n 
A 1 533 SER 533 796 ?   ?   ?   A . n 
A 1 534 ILE 534 797 ?   ?   ?   A . n 
A 1 535 HIS 535 798 ?   ?   ?   A . n 
A 1 536 ALA 536 799 ?   ?   ?   A . n 
A 1 537 THR 537 800 800 THR THR A . n 
A 1 538 HIS 538 801 801 HIS HIS A . n 
A 1 539 GLU 539 802 802 GLU GLU A . n 
A 1 540 TRP 540 803 803 TRP TRP A . n 
A 1 541 MET 541 804 804 MET MET A . n 
A 1 542 THR 542 805 805 THR THR A . n 
A 1 543 THR 543 806 806 THR THR A . n 
A 1 544 GLU 544 807 807 GLU GLU A . n 
A 1 545 ASP 545 808 808 ASP ASP A . n 
A 1 546 MET 546 809 809 MET MET A . n 
A 1 547 LEU 547 810 810 LEU LEU A . n 
A 1 548 THR 548 811 811 THR THR A . n 
A 1 549 VAL 549 812 812 VAL VAL A . n 
A 1 550 TRP 550 813 813 TRP TRP A . n 
A 1 551 ASN 551 814 814 ASN ASN A . n 
A 1 552 ARG 552 815 815 ARG ARG A . n 
A 1 553 VAL 553 816 816 VAL VAL A . n 
A 1 554 TRP 554 817 817 TRP TRP A . n 
A 1 555 ILE 555 818 818 ILE ILE A . n 
A 1 556 GLN 556 819 819 GLN GLN A . n 
A 1 557 GLU 557 820 820 GLU GLU A . n 
A 1 558 ASN 558 821 821 ASN ASN A . n 
A 1 559 PRO 559 822 822 PRO PRO A . n 
A 1 560 TRP 560 823 823 TRP TRP A . n 
A 1 561 MET 561 824 824 MET MET A . n 
A 1 562 GLU 562 825 825 GLU GLU A . n 
A 1 563 ASP 563 826 826 ASP ASP A . n 
A 1 564 LYS 564 827 827 LYS LYS A . n 
A 1 565 THR 565 828 828 THR THR A . n 
A 1 566 PRO 566 829 829 PRO PRO A . n 
A 1 567 VAL 567 830 830 VAL VAL A . n 
A 1 568 GLU 568 831 831 GLU GLU A . n 
A 1 569 SER 569 832 832 SER SER A . n 
A 1 570 TRP 570 833 833 TRP TRP A . n 
A 1 571 GLU 571 834 834 GLU GLU A . n 
A 1 572 GLU 572 835 835 GLU GLU A . n 
A 1 573 ILE 573 836 836 ILE ILE A . n 
A 1 574 PRO 574 837 837 PRO PRO A . n 
A 1 575 TYR 575 838 838 TYR TYR A . n 
A 1 576 LEU 576 839 839 LEU LEU A . n 
A 1 577 GLY 577 840 840 GLY GLY A . n 
A 1 578 LYS 578 841 841 LYS LYS A . n 
A 1 579 ARG 579 842 842 ARG ARG A . n 
A 1 580 GLU 580 843 843 GLU GLU A . n 
A 1 581 ASP 581 844 844 ASP ASP A . n 
A 1 582 GLN 582 845 845 GLN GLN A . n 
A 1 583 TRP 583 846 846 TRP TRP A . n 
A 1 584 CYS 584 847 847 CYS CYS A . n 
A 1 585 GLY 585 848 848 GLY GLY A . n 
A 1 586 SER 586 849 849 SER SER A . n 
A 1 587 LEU 587 850 850 LEU LEU A . n 
A 1 588 ILE 588 851 851 ILE ILE A . n 
A 1 589 GLY 589 852 852 GLY GLY A . n 
A 1 590 LEU 590 853 853 LEU LEU A . n 
A 1 591 THR 591 854 854 THR THR A . n 
A 1 592 SER 592 855 855 SER SER A . n 
A 1 593 ARG 593 856 856 ARG ARG A . n 
A 1 594 ALA 594 857 857 ALA ALA A . n 
A 1 595 THR 595 858 858 THR THR A . n 
A 1 596 TRP 596 859 859 TRP TRP A . n 
A 1 597 ALA 597 860 860 ALA ALA A . n 
A 1 598 LYS 598 861 861 LYS LYS A . n 
A 1 599 ASN 599 862 862 ASN ASN A . n 
A 1 600 ILE 600 863 863 ILE ILE A . n 
A 1 601 GLN 601 864 864 GLN GLN A . n 
A 1 602 THR 602 865 865 THR THR A . n 
A 1 603 ALA 603 866 866 ALA ALA A . n 
A 1 604 ILE 604 867 867 ILE ILE A . n 
A 1 605 ASN 605 868 868 ASN ASN A . n 
A 1 606 GLN 606 869 869 GLN GLN A . n 
A 1 607 VAL 607 870 870 VAL VAL A . n 
A 1 608 ARG 608 871 871 ARG ARG A . n 
A 1 609 SER 609 872 872 SER SER A . n 
A 1 610 LEU 610 873 873 LEU LEU A . n 
A 1 611 ILE 611 874 874 ILE ILE A . n 
A 1 612 GLY 612 875 875 GLY GLY A . n 
A 1 613 ASN 613 876 876 ASN ASN A . n 
A 1 614 GLU 614 877 877 GLU GLU A . n 
A 1 615 GLU 615 878 878 GLU GLU A . n 
A 1 616 TYR 616 879 879 TYR TYR A . n 
A 1 617 THR 617 880 880 THR THR A . n 
A 1 618 ASP 618 881 881 ASP ASP A . n 
A 1 619 TYR 619 882 882 TYR TYR A . n 
A 1 620 MET 620 883 883 MET MET A . n 
A 1 621 PRO 621 884 884 PRO PRO A . n 
A 1 622 SER 622 885 885 SER SER A . n 
A 1 623 MET 623 886 886 MET MET A . n 
A 1 624 LYS 624 887 887 LYS LYS A . n 
A 1 625 ARG 625 888 888 ARG ARG A . n 
A 1 626 PHE 626 889 889 PHE PHE A . n 
A 1 627 ARG 627 890 890 ARG ARG A . n 
A 1 628 ARG 628 891 891 ARG ARG A . n 
A 1 629 GLU 629 892 ?   ?   ?   A . n 
A 1 630 GLU 630 893 ?   ?   ?   A . n 
A 1 631 GLU 631 894 ?   ?   ?   A . n 
A 1 632 GLU 632 895 ?   ?   ?   A . n 
A 1 633 ALA 633 896 ?   ?   ?   A . n 
A 1 634 GLY 634 897 ?   ?   ?   A . n 
A 1 635 VAL 635 898 ?   ?   ?   A . n 
A 1 636 LEU 636 899 ?   ?   ?   A . n 
A 1 637 TRP 637 900 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        JGP 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   JGP 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 ZN  1   1001 1001 ZN  ZN  A . 
C 2 ZN  1   1002 1002 ZN  ZN  A . 
D 3 MES 1   1003 1004 MES MES A . 
E 4 DMS 1   1004 1530 DMS DMS A . 
F 4 DMS 1   1005 1601 DMS DMS A . 
G 5 PO4 1   1006 1604 PO4 PO4 A . 
H 5 PO4 1   1007 1606 PO4 PO4 A . 
I 6 PEG 1   1008 1607 PEG PEG A . 
J 7 CL  1   1009 2001 CL  CL  A . 
K 8 JGP 1   1010 2101 JGP LIG A . 
L 9 HOH 1   1101 230  HOH HOH A . 
L 9 HOH 2   1102 189  HOH HOH A . 
L 9 HOH 3   1103 209  HOH HOH A . 
L 9 HOH 4   1104 388  HOH HOH A . 
L 9 HOH 5   1105 243  HOH HOH A . 
L 9 HOH 6   1106 214  HOH HOH A . 
L 9 HOH 7   1107 259  HOH HOH A . 
L 9 HOH 8   1108 280  HOH HOH A . 
L 9 HOH 9   1109 11   HOH HOH A . 
L 9 HOH 10  1110 248  HOH HOH A . 
L 9 HOH 11  1111 177  HOH HOH A . 
L 9 HOH 12  1112 274  HOH HOH A . 
L 9 HOH 13  1113 258  HOH HOH A . 
L 9 HOH 14  1114 396  HOH HOH A . 
L 9 HOH 15  1115 220  HOH HOH A . 
L 9 HOH 16  1116 288  HOH HOH A . 
L 9 HOH 17  1117 191  HOH HOH A . 
L 9 HOH 18  1118 166  HOH HOH A . 
L 9 HOH 19  1119 236  HOH HOH A . 
L 9 HOH 20  1120 276  HOH HOH A . 
L 9 HOH 21  1121 206  HOH HOH A . 
L 9 HOH 22  1122 176  HOH HOH A . 
L 9 HOH 23  1123 348  HOH HOH A . 
L 9 HOH 24  1124 27   HOH HOH A . 
L 9 HOH 25  1125 185  HOH HOH A . 
L 9 HOH 26  1126 341  HOH HOH A . 
L 9 HOH 27  1127 197  HOH HOH A . 
L 9 HOH 28  1128 294  HOH HOH A . 
L 9 HOH 29  1129 217  HOH HOH A . 
L 9 HOH 30  1130 204  HOH HOH A . 
L 9 HOH 31  1131 180  HOH HOH A . 
L 9 HOH 32  1132 254  HOH HOH A . 
L 9 HOH 33  1133 201  HOH HOH A . 
L 9 HOH 34  1134 175  HOH HOH A . 
L 9 HOH 35  1135 250  HOH HOH A . 
L 9 HOH 36  1136 109  HOH HOH A . 
L 9 HOH 37  1137 46   HOH HOH A . 
L 9 HOH 38  1138 232  HOH HOH A . 
L 9 HOH 39  1139 277  HOH HOH A . 
L 9 HOH 40  1140 239  HOH HOH A . 
L 9 HOH 41  1141 223  HOH HOH A . 
L 9 HOH 42  1142 186  HOH HOH A . 
L 9 HOH 43  1143 458  HOH HOH A . 
L 9 HOH 44  1144 318  HOH HOH A . 
L 9 HOH 45  1145 247  HOH HOH A . 
L 9 HOH 46  1146 52   HOH HOH A . 
L 9 HOH 47  1147 210  HOH HOH A . 
L 9 HOH 48  1148 196  HOH HOH A . 
L 9 HOH 49  1149 227  HOH HOH A . 
L 9 HOH 50  1150 187  HOH HOH A . 
L 9 HOH 51  1151 34   HOH HOH A . 
L 9 HOH 52  1152 238  HOH HOH A . 
L 9 HOH 53  1153 184  HOH HOH A . 
L 9 HOH 54  1154 257  HOH HOH A . 
L 9 HOH 55  1155 346  HOH HOH A . 
L 9 HOH 56  1156 2    HOH HOH A . 
L 9 HOH 57  1157 251  HOH HOH A . 
L 9 HOH 58  1158 303  HOH HOH A . 
L 9 HOH 59  1159 190  HOH HOH A . 
L 9 HOH 60  1160 182  HOH HOH A . 
L 9 HOH 61  1161 215  HOH HOH A . 
L 9 HOH 62  1162 6    HOH HOH A . 
L 9 HOH 63  1163 179  HOH HOH A . 
L 9 HOH 64  1164 325  HOH HOH A . 
L 9 HOH 65  1165 86   HOH HOH A . 
L 9 HOH 66  1166 69   HOH HOH A . 
L 9 HOH 67  1167 143  HOH HOH A . 
L 9 HOH 68  1168 213  HOH HOH A . 
L 9 HOH 69  1169 205  HOH HOH A . 
L 9 HOH 70  1170 45   HOH HOH A . 
L 9 HOH 71  1171 245  HOH HOH A . 
L 9 HOH 72  1172 199  HOH HOH A . 
L 9 HOH 73  1173 278  HOH HOH A . 
L 9 HOH 74  1174 261  HOH HOH A . 
L 9 HOH 75  1175 308  HOH HOH A . 
L 9 HOH 76  1176 253  HOH HOH A . 
L 9 HOH 77  1177 211  HOH HOH A . 
L 9 HOH 78  1178 300  HOH HOH A . 
L 9 HOH 79  1179 198  HOH HOH A . 
L 9 HOH 80  1180 285  HOH HOH A . 
L 9 HOH 81  1181 321  HOH HOH A . 
L 9 HOH 82  1182 244  HOH HOH A . 
L 9 HOH 83  1183 234  HOH HOH A . 
L 9 HOH 84  1184 202  HOH HOH A . 
L 9 HOH 85  1185 188  HOH HOH A . 
L 9 HOH 86  1186 262  HOH HOH A . 
L 9 HOH 87  1187 281  HOH HOH A . 
L 9 HOH 88  1188 62   HOH HOH A . 
L 9 HOH 89  1189 289  HOH HOH A . 
L 9 HOH 90  1190 302  HOH HOH A . 
L 9 HOH 91  1191 222  HOH HOH A . 
L 9 HOH 92  1192 207  HOH HOH A . 
L 9 HOH 93  1193 296  HOH HOH A . 
L 9 HOH 94  1194 122  HOH HOH A . 
L 9 HOH 95  1195 18   HOH HOH A . 
L 9 HOH 96  1196 195  HOH HOH A . 
L 9 HOH 97  1197 292  HOH HOH A . 
L 9 HOH 98  1198 290  HOH HOH A . 
L 9 HOH 99  1199 309  HOH HOH A . 
L 9 HOH 100 1200 418  HOH HOH A . 
L 9 HOH 101 1201 38   HOH HOH A . 
L 9 HOH 102 1202 91   HOH HOH A . 
L 9 HOH 103 1203 464  HOH HOH A . 
L 9 HOH 104 1204 231  HOH HOH A . 
L 9 HOH 105 1205 338  HOH HOH A . 
L 9 HOH 106 1206 92   HOH HOH A . 
L 9 HOH 107 1207 312  HOH HOH A . 
L 9 HOH 108 1208 148  HOH HOH A . 
L 9 HOH 109 1209 315  HOH HOH A . 
L 9 HOH 110 1210 365  HOH HOH A . 
L 9 HOH 111 1211 240  HOH HOH A . 
L 9 HOH 112 1212 252  HOH HOH A . 
L 9 HOH 113 1213 331  HOH HOH A . 
L 9 HOH 114 1214 265  HOH HOH A . 
L 9 HOH 115 1215 298  HOH HOH A . 
L 9 HOH 116 1216 178  HOH HOH A . 
L 9 HOH 117 1217 350  HOH HOH A . 
L 9 HOH 118 1218 260  HOH HOH A . 
L 9 HOH 119 1219 368  HOH HOH A . 
L 9 HOH 120 1220 306  HOH HOH A . 
L 9 HOH 121 1221 333  HOH HOH A . 
L 9 HOH 122 1222 136  HOH HOH A . 
L 9 HOH 123 1223 233  HOH HOH A . 
L 9 HOH 124 1224 320  HOH HOH A . 
L 9 HOH 125 1225 361  HOH HOH A . 
L 9 HOH 126 1226 241  HOH HOH A . 
L 9 HOH 127 1227 219  HOH HOH A . 
L 9 HOH 128 1228 129  HOH HOH A . 
L 9 HOH 129 1229 270  HOH HOH A . 
L 9 HOH 130 1230 268  HOH HOH A . 
L 9 HOH 131 1231 372  HOH HOH A . 
L 9 HOH 132 1232 16   HOH HOH A . 
L 9 HOH 133 1233 12   HOH HOH A . 
L 9 HOH 134 1234 246  HOH HOH A . 
L 9 HOH 135 1235 314  HOH HOH A . 
L 9 HOH 136 1236 377  HOH HOH A . 
L 9 HOH 137 1237 269  HOH HOH A . 
L 9 HOH 138 1238 355  HOH HOH A . 
L 9 HOH 139 1239 67   HOH HOH A . 
L 9 HOH 140 1240 304  HOH HOH A . 
L 9 HOH 141 1241 363  HOH HOH A . 
L 9 HOH 142 1242 389  HOH HOH A . 
L 9 HOH 143 1243 367  HOH HOH A . 
L 9 HOH 144 1244 75   HOH HOH A . 
L 9 HOH 145 1245 322  HOH HOH A . 
L 9 HOH 146 1246 342  HOH HOH A . 
L 9 HOH 147 1247 42   HOH HOH A . 
L 9 HOH 148 1248 284  HOH HOH A . 
L 9 HOH 149 1249 416  HOH HOH A . 
L 9 HOH 150 1250 334  HOH HOH A . 
L 9 HOH 151 1251 83   HOH HOH A . 
L 9 HOH 152 1252 335  HOH HOH A . 
L 9 HOH 153 1253 330  HOH HOH A . 
L 9 HOH 154 1254 378  HOH HOH A . 
L 9 HOH 155 1255 339  HOH HOH A . 
L 9 HOH 156 1256 32   HOH HOH A . 
L 9 HOH 157 1257 347  HOH HOH A . 
L 9 HOH 158 1258 357  HOH HOH A . 
L 9 HOH 159 1259 316  HOH HOH A . 
L 9 HOH 160 1260 297  HOH HOH A . 
L 9 HOH 161 1261 275  HOH HOH A . 
L 9 HOH 162 1262 413  HOH HOH A . 
L 9 HOH 163 1263 394  HOH HOH A . 
L 9 HOH 164 1264 287  HOH HOH A . 
L 9 HOH 165 1265 364  HOH HOH A . 
L 9 HOH 166 1266 216  HOH HOH A . 
L 9 HOH 167 1267 271  HOH HOH A . 
L 9 HOH 168 1268 203  HOH HOH A . 
L 9 HOH 169 1269 255  HOH HOH A . 
L 9 HOH 170 1270 344  HOH HOH A . 
L 9 HOH 171 1271 4    HOH HOH A . 
L 9 HOH 172 1272 106  HOH HOH A . 
L 9 HOH 173 1273 313  HOH HOH A . 
L 9 HOH 174 1274 200  HOH HOH A . 
L 9 HOH 175 1275 305  HOH HOH A . 
L 9 HOH 176 1276 128  HOH HOH A . 
L 9 HOH 177 1277 282  HOH HOH A . 
L 9 HOH 178 1278 328  HOH HOH A . 
L 9 HOH 179 1279 218  HOH HOH A . 
L 9 HOH 180 1280 463  HOH HOH A . 
L 9 HOH 181 1281 392  HOH HOH A . 
L 9 HOH 182 1282 319  HOH HOH A . 
L 9 HOH 183 1283 423  HOH HOH A . 
L 9 HOH 184 1284 56   HOH HOH A . 
L 9 HOH 185 1285 384  HOH HOH A . 
L 9 HOH 186 1286 369  HOH HOH A . 
L 9 HOH 187 1287 131  HOH HOH A . 
L 9 HOH 188 1288 349  HOH HOH A . 
L 9 HOH 189 1289 272  HOH HOH A . 
L 9 HOH 190 1290 256  HOH HOH A . 
L 9 HOH 191 1291 323  HOH HOH A . 
L 9 HOH 192 1292 402  HOH HOH A . 
L 9 HOH 193 1293 249  HOH HOH A . 
L 9 HOH 194 1294 351  HOH HOH A . 
L 9 HOH 195 1295 30   HOH HOH A . 
L 9 HOH 196 1296 374  HOH HOH A . 
L 9 HOH 197 1297 373  HOH HOH A . 
L 9 HOH 198 1298 406  HOH HOH A . 
L 9 HOH 199 1299 404  HOH HOH A . 
L 9 HOH 200 1300 15   HOH HOH A . 
L 9 HOH 201 1301 393  HOH HOH A . 
L 9 HOH 202 1302 70   HOH HOH A . 
L 9 HOH 203 1303 89   HOH HOH A . 
L 9 HOH 204 1304 33   HOH HOH A . 
L 9 HOH 205 1305 279  HOH HOH A . 
L 9 HOH 206 1306 360  HOH HOH A . 
L 9 HOH 207 1307 295  HOH HOH A . 
L 9 HOH 208 1308 14   HOH HOH A . 
L 9 HOH 209 1309 127  HOH HOH A . 
L 9 HOH 210 1310 383  HOH HOH A . 
L 9 HOH 211 1311 399  HOH HOH A . 
L 9 HOH 212 1312 467  HOH HOH A . 
L 9 HOH 213 1313 371  HOH HOH A . 
L 9 HOH 214 1314 391  HOH HOH A . 
L 9 HOH 215 1315 366  HOH HOH A . 
L 9 HOH 216 1316 398  HOH HOH A . 
L 9 HOH 217 1317 469  HOH HOH A . 
L 9 HOH 218 1318 352  HOH HOH A . 
L 9 HOH 219 1319 311  HOH HOH A . 
L 9 HOH 220 1320 380  HOH HOH A . 
L 9 HOH 221 1321 379  HOH HOH A . 
L 9 HOH 222 1322 376  HOH HOH A . 
L 9 HOH 223 1323 411  HOH HOH A . 
L 9 HOH 224 1324 390  HOH HOH A . 
L 9 HOH 225 1325 326  HOH HOH A . 
L 9 HOH 226 1326 381  HOH HOH A . 
L 9 HOH 227 1327 111  HOH HOH A . 
L 9 HOH 228 1328 99   HOH HOH A . 
L 9 HOH 229 1329 417  HOH HOH A . 
L 9 HOH 230 1330 359  HOH HOH A . 
L 9 HOH 231 1331 48   HOH HOH A . 
L 9 HOH 232 1332 386  HOH HOH A . 
L 9 HOH 233 1333 80   HOH HOH A . 
L 9 HOH 234 1334 97   HOH HOH A . 
L 9 HOH 235 1335 132  HOH HOH A . 
L 9 HOH 236 1336 427  HOH HOH A . 
L 9 HOH 237 1337 412  HOH HOH A . 
L 9 HOH 238 1338 407  HOH HOH A . 
L 9 HOH 239 1339 307  HOH HOH A . 
L 9 HOH 240 1340 43   HOH HOH A . 
L 9 HOH 241 1341 126  HOH HOH A . 
L 9 HOH 242 1342 410  HOH HOH A . 
L 9 HOH 243 1343 409  HOH HOH A . 
L 9 HOH 244 1344 414  HOH HOH A . 
L 9 HOH 245 1345 468  HOH HOH A . 
L 9 HOH 246 1346 123  HOH HOH A . 
L 9 HOH 247 1347 120  HOH HOH A . 
L 9 HOH 248 1348 340  HOH HOH A . 
L 9 HOH 249 1349 422  HOH HOH A . 
L 9 HOH 250 1350 462  HOH HOH A . 
L 9 HOH 251 1351 415  HOH HOH A . 
L 9 HOH 252 1352 40   HOH HOH A . 
L 9 HOH 253 1353 114  HOH HOH A . 
L 9 HOH 254 1354 337  HOH HOH A . 
L 9 HOH 255 1355 117  HOH HOH A . 
L 9 HOH 256 1356 434  HOH HOH A . 
L 9 HOH 257 1357 461  HOH HOH A . 
L 9 HOH 258 1358 444  HOH HOH A . 
L 9 HOH 259 1359 466  HOH HOH A . 
L 9 HOH 260 1360 324  HOH HOH A . 
L 9 HOH 261 1361 431  HOH HOH A . 
L 9 HOH 262 1362 436  HOH HOH A . 
L 9 HOH 263 1363 428  HOH HOH A . 
L 9 HOH 264 1364 1    HOH HOH A . 
L 9 HOH 265 1365 439  HOH HOH A . 
L 9 HOH 266 1366 88   HOH HOH A . 
L 9 HOH 267 1367 137  HOH HOH A . 
L 9 HOH 268 1368 437  HOH HOH A . 
L 9 HOH 269 1369 424  HOH HOH A . 
L 9 HOH 270 1370 430  HOH HOH A . 
L 9 HOH 271 1371 426  HOH HOH A . 
L 9 HOH 272 1372 96   HOH HOH A . 
L 9 HOH 273 1373 465  HOH HOH A . 
L 9 HOH 274 1374 429  HOH HOH A . 
L 9 HOH 275 1375 459  HOH HOH A . 
L 9 HOH 276 1376 9    HOH HOH A . 
L 9 HOH 277 1377 435  HOH HOH A . 
L 9 HOH 278 1378 438  HOH HOH A . 
L 9 HOH 279 1379 301  HOH HOH A . 
L 9 HOH 280 1380 51   HOH HOH A . 
L 9 HOH 281 1381 63   HOH HOH A . 
L 9 HOH 282 1382 82   HOH HOH A . 
L 9 HOH 283 1383 8    HOH HOH A . 
L 9 HOH 284 1384 121  HOH HOH A . 
L 9 HOH 285 1385 443  HOH HOH A . 
L 9 HOH 286 1386 420  HOH HOH A . 
L 9 HOH 287 1387 445  HOH HOH A . 
L 9 HOH 288 1388 441  HOH HOH A . 
L 9 HOH 289 1389 78   HOH HOH A . 
L 9 HOH 290 1390 403  HOH HOH A . 
L 9 HOH 291 1391 419  HOH HOH A . 
L 9 HOH 292 1392 440  HOH HOH A . 
L 9 HOH 293 1393 447  HOH HOH A . 
L 9 HOH 294 1394 172  HOH HOH A . 
L 9 HOH 295 1395 53   HOH HOH A . 
L 9 HOH 296 1396 135  HOH HOH A . 
L 9 HOH 297 1397 332  HOH HOH A . 
L 9 HOH 298 1398 104  HOH HOH A . 
L 9 HOH 299 1399 95   HOH HOH A . 
L 9 HOH 300 1400 49   HOH HOH A . 
L 9 HOH 301 1401 130  HOH HOH A . 
L 9 HOH 302 1402 450  HOH HOH A . 
L 9 HOH 303 1403 73   HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A THR 344 ? CB  ? A THR 81 CB  
2 1 Y 1 A THR 344 ? OG1 ? A THR 81 OG1 
3 1 Y 1 A THR 344 ? CG2 ? A THR 81 CG2 
# 
loop_
_software.classification 
_software.name 
_software.version 
_software.citation_id 
_software.pdbx_ordinal 
_software.date 
_software.type 
_software.location 
_software.language 
refinement       REFMAC  5.8.0267 ? 1 ? ? ? ? 
'data scaling'   Aimless .        ? 2 ? ? ? ? 
phasing          PHASER  .        ? 3 ? ? ? ? 
'data reduction' XDS     .        ? 4 ? ? ? ? 
# 
_cell.entry_id           7I2R 
_cell.length_a           81.930 
_cell.length_b           115.957 
_cell.length_c           148.578 
_cell.angle_alpha        90.00 
_cell.angle_beta         90.00 
_cell.angle_gamma        90.00 
_cell.Z_PDB              8 
_cell.pdbx_unique_axis   ? 
# 
_symmetry.entry_id                         7I2R 
_symmetry.space_group_name_H-M             'I 2 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                23 
# 
_exptl.entry_id          7I2R 
_exptl.method            'X-RAY DIFFRACTION' 
_exptl.crystals_number   1 
# 
_exptl_crystal.id                    1 
_exptl_crystal.density_meas          ? 
_exptl_crystal.density_Matthews      2.39 
_exptl_crystal.density_percent_sol   48.49 
_exptl_crystal.description           ? 
_exptl_crystal.preparation           ? 
# 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.temp            293.15 
_exptl_crystal_grow.pdbx_details    '350 mM Magnesium chloride, 10% PEG 4000, 100 mM MES, pH 6.5' 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.pdbx_pH_range   ? 
# 
_diffrn.id                               1 
_diffrn.ambient_temp                     100 
_diffrn.crystal_id                       1 
_diffrn.ambient_temp_details             ? 
_diffrn.pdbx_serial_crystal_experiment   ? 
# 
_diffrn_detector.detector               PIXEL 
_diffrn_detector.type                   'DECTRIS EIGER2 XE 9M' 
_diffrn_detector.pdbx_collection_date   2023-12-05 
_diffrn_detector.diffrn_id              1 
_diffrn_detector.details                ? 
# 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.92124 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.diffrn_id                   1 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.type                        'DIAMOND BEAMLINE I04-1' 
_diffrn_source.pdbx_wavelength_list        0.92124 
_diffrn_source.pdbx_synchrotron_site       Diamond 
_diffrn_source.pdbx_synchrotron_beamline   I04-1 
_diffrn_source.pdbx_wavelength             ? 
# 
_reflns.entry_id                     7I2R 
_reflns.pdbx_diffrn_id               1 
_reflns.pdbx_ordinal                 1 
_reflns.d_resolution_low             45.71 
_reflns.d_resolution_high            1.80 
_reflns.number_obs                   65705 
_reflns.percent_possible_obs         100.0 
_reflns.pdbx_Rmerge_I_obs            0.166 
_reflns.pdbx_netI_over_sigmaI        9.1 
_reflns.pdbx_redundancy              13.7 
_reflns.pdbx_Rrim_I_all              0.172 
_reflns.pdbx_Rpim_I_all              0.046 
_reflns.pdbx_CC_half                 0.999 
_reflns.pdbx_number_measured_all     901257 
_reflns.pdbx_chi_squared             0.35 
_reflns.observed_criterion_sigma_I   ? 
_reflns.observed_criterion_sigma_F   ? 
_reflns.number_all                   ? 
_reflns.pdbx_Rsym_value              ? 
_reflns.B_iso_Wilson_estimate        ? 
_reflns.pdbx_CC_star                 ? 
# 
_reflns_shell.pdbx_diffrn_id              1 
_reflns_shell.pdbx_ordinal                1 
_reflns_shell.d_res_high                  1.80 
_reflns_shell.d_res_low                   1.84 
_reflns_shell.number_measured_all         53920 
_reflns_shell.number_unique_obs           3834 
_reflns_shell.Rmerge_I_obs                5.707 
_reflns_shell.pdbx_chi_squared            0.16 
_reflns_shell.pdbx_redundancy             14.1 
_reflns_shell.percent_possible_obs        99.3 
_reflns_shell.pdbx_netI_over_sigmaI_obs   0.2 
_reflns_shell.pdbx_Rrim_I_all             5.923 
_reflns_shell.pdbx_Rpim_I_all             1.576 
_reflns_shell.pdbx_CC_half                0.416 
_reflns_shell.percent_possible_all        ? 
_reflns_shell.pdbx_Rsym_value             ? 
_reflns_shell.meanI_over_sigI_obs         ? 
_reflns_shell.number_measured_obs         ? 
_reflns_shell.number_unique_all           ? 
_reflns_shell.pdbx_CC_star                ? 
# 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.entry_id                                 7I2R 
_refine.pdbx_diffrn_id                           1 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     60905 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             45.75 
_refine.ls_d_res_high                            1.80 
_refine.ls_percent_reflns_obs                    97.62 
_refine.ls_R_factor_obs                          0.21091 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       0.20895 
_refine.ls_R_factor_R_free                       0.24628 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 5.2 
_refine.ls_number_reflns_R_free                  3312 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               0.960 
_refine.correlation_coeff_Fo_to_Fc_free          0.953 
_refine.B_iso_mean                               61.167 
_refine.aniso_B[1][1]                            -3.32 
_refine.aniso_B[2][2]                            0.59 
_refine.aniso_B[3][3]                            2.73 
_refine.aniso_B[1][2]                            -0.00 
_refine.aniso_B[1][3]                            -0.00 
_refine.aniso_B[2][3]                            -0.00 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_overall_ESU_R                       0.385 
_refine.pdbx_overall_ESU_R_Free                  0.203 
_refine.overall_SU_ML                            0.302 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             11.833 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.pdbx_number_atoms_protein        4597 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         58 
_refine_hist.number_atoms_solvent             303 
_refine_hist.number_atoms_total               4958 
_refine_hist.d_res_high                       1.80 
_refine_hist.d_res_low                        45.75 
# 
loop_
_refine_ls_restr.type 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.weight 
_refine_ls_restr.number 
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.pdbx_restraint_function 
r_bond_refined_d             0.005  0.015  ? 17099 'X-RAY DIFFRACTION' ? 
r_bond_other_d               0.001  0.015  ? 11020 'X-RAY DIFFRACTION' ? 
r_angle_refined_deg          1.335  1.647  ? 16006 'X-RAY DIFFRACTION' ? 
r_angle_other_deg            1.171  1.594  ? 25541 'X-RAY DIFFRACTION' ? 
r_dihedral_angle_1_deg       5.811  5.000  ? 1478  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_2_deg       29.914 21.724 ? 673   'X-RAY DIFFRACTION' ? 
r_dihedral_angle_3_deg       15.587 15.000 ? 2209  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_4_deg       16.577 15.000 ? 98    'X-RAY DIFFRACTION' ? 
r_chiral_restr               0.058  0.200  ? 1442  'X-RAY DIFFRACTION' ? 
r_gen_planes_refined         0.006  0.020  ? 13748 'X-RAY DIFFRACTION' ? 
r_gen_planes_other           0.001  0.020  ? 2848  'X-RAY DIFFRACTION' ? 
r_nbd_refined                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbd_other                  ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_refined              ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_other                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_refined        ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_other          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_refined          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_other            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_refined       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_other         ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_refined     ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_other       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_refined ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_other   ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_mcbond_it                  2.487  5.918  ? 8291  'X-RAY DIFFRACTION' ? 
r_mcbond_other               2.530  5.954  ? 8009  'X-RAY DIFFRACTION' ? 
r_mcangle_it                 4.880  8.713  ? 7166  'X-RAY DIFFRACTION' ? 
r_mcangle_other              4.880  8.713  ? 7167  'X-RAY DIFFRACTION' ? 
r_scbond_it                  2.708  6.648  ? 8770  'X-RAY DIFFRACTION' ? 
r_scbond_other               2.707  6.648  ? 8771  'X-RAY DIFFRACTION' ? 
r_scangle_it                 ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_scangle_other              5.110  9.530  ? 8787  'X-RAY DIFFRACTION' ? 
r_long_range_B_refined       13.511 59.454 ? 12417 'X-RAY DIFFRACTION' ? 
r_long_range_B_other         13.499 59.294 ? 12211 'X-RAY DIFFRACTION' ? 
r_rigid_bond_restr           ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_free            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_bonded          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.d_res_high                       1.800 
_refine_ls_shell.d_res_low                        1.847 
_refine_ls_shell.number_reflns_R_work             3256 
_refine_ls_shell.R_factor_R_work                  0.524 
_refine_ls_shell.percent_reflns_obs               70.84 
_refine_ls_shell.R_factor_R_free                  0.538 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.number_reflns_R_free             157 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.number_reflns_obs                ? 
# 
_struct.entry_id                  7I2R 
_struct.title                     
;Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z31432226 (DNV2_NS5A-x0759)
;
_struct.pdbx_model_details        ? 
_struct.pdbx_CASP_flag            ? 
_struct.pdbx_model_type_details   ? 
# 
_struct_keywords.entry_id        7I2R 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
_struct_keywords.text            
;Diamond Light Source, I04-1, READDI, Dengue Virus, crystallographic fragment screening, PanDDA, XChemExplorer, cluster4x, VIRAL PROTEIN
;
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 5 ? 
H N N 5 ? 
I N N 6 ? 
J N N 7 ? 
K N N 8 ? 
L N N 9 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q91H74_9FLAV 
_struct_ref.pdbx_db_accession          Q91H74 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;GIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAMTD
TTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAREA
VEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLS
GVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRPTP
RGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGDDC
VVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQGAG
WSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPWME
DKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_struct_ref.pdbx_align_begin           2757 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              7I2R 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 3 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 637 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q91H74 
_struct_ref_seq.db_align_beg                  2757 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3391 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       266 
_struct_ref_seq.pdbx_auth_seq_align_end       900 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 7I2R GLY A 1 ? UNP Q91H74 ? ? 'expression tag' 264 1 
1 7I2R PRO A 2 ? UNP Q91H74 ? ? 'expression tag' 265 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 10  ? HIS A 25  ? ASN A 273 HIS A 288 1 ? 16 
HELX_P HELX_P2  AA2 ASN A 59  ? LEU A 65  ? ASN A 322 LEU A 328 1 ? 7  
HELX_P HELX_P3  AA3 THR A 66  ? ILE A 71  ? THR A 329 ILE A 334 5 ? 6  
HELX_P HELX_P4  AA4 ILE A 72  ? MET A 78  ? ILE A 335 MET A 341 1 ? 7  
HELX_P HELX_P5  AA5 LYS A 104 ? LYS A 124 ? LYS A 367 LYS A 387 1 ? 21 
HELX_P HELX_P6  AA6 THR A 132 ? ARG A 141 ? THR A 395 ARG A 404 1 ? 10 
HELX_P HELX_P7  AA7 SER A 158 ? GLU A 164 ? SER A 421 GLU A 427 1 ? 7  
HELX_P HELX_P8  AA8 ASP A 165 ? GLU A 181 ? ASP A 428 GLU A 444 1 ? 17 
HELX_P HELX_P9  AA9 TRP A 215 ? GLY A 227 ? TRP A 478 GLY A 490 1 ? 13 
HELX_P HELX_P10 AB1 GLY A 227 ? ASP A 232 ? GLY A 490 ASP A 495 1 ? 6  
HELX_P HELX_P11 AB2 SER A 236 ? LEU A 241 ? SER A 499 LEU A 504 1 ? 6  
HELX_P HELX_P12 AB3 GLY A 248 ? LYS A 262 ? GLY A 511 LYS A 525 1 ? 15 
HELX_P HELX_P13 AB4 GLY A 274 ? ILE A 279 ? GLY A 537 ILE A 542 5 ? 6  
HELX_P HELX_P14 AB5 THR A 280 ? MET A 289 ? THR A 543 MET A 552 1 ? 10 
HELX_P HELX_P15 AB6 VAL A 290 ? MET A 294 ? VAL A 553 MET A 557 5 ? 5  
HELX_P HELX_P16 AB7 GLU A 295 ? TYR A 310 ? GLU A 558 TYR A 573 1 ? 16 
HELX_P HELX_P17 AB8 GLY A 339 ? GLY A 364 ? GLY A 602 GLY A 627 1 ? 26 
HELX_P HELX_P18 AB9 THR A 373 ? SER A 393 ? THR A 636 SER A 656 1 ? 21 
HELX_P HELX_P19 AC1 ASP A 408 ? ALA A 414 ? ASP A 671 ALA A 677 5 ? 7  
HELX_P HELX_P20 AC2 LEU A 415 ? MET A 421 ? LEU A 678 MET A 684 1 ? 7  
HELX_P HELX_P21 AC3 ASP A 439 ? VAL A 443 ? ASP A 702 VAL A 706 5 ? 5  
HELX_P HELX_P22 AC4 ASN A 467 ? ARG A 476 ? ASN A 730 ARG A 739 1 ? 10 
HELX_P HELX_P23 AC5 SER A 484 ? TYR A 503 ? SER A 747 TYR A 766 1 ? 20 
HELX_P HELX_P24 AC6 ARG A 506 ? VAL A 520 ? ARG A 769 VAL A 783 1 ? 15 
HELX_P HELX_P25 AC7 ASP A 545 ? ILE A 555 ? ASP A 808 ILE A 818 1 ? 11 
HELX_P HELX_P26 AC8 SER A 569 ? ILE A 573 ? SER A 832 ILE A 836 5 ? 5  
HELX_P HELX_P27 AC9 GLY A 577 ? CYS A 584 ? GLY A 840 CYS A 847 1 ? 8  
HELX_P HELX_P28 AD1 LEU A 590 ? ASN A 599 ? LEU A 853 ASN A 862 1 ? 10 
HELX_P HELX_P29 AD2 ASN A 599 ? GLY A 612 ? ASN A 862 GLY A 875 1 ? 14 
HELX_P HELX_P30 AD3 TYR A 619 ? ARG A 627 ? TYR A 882 ARG A 890 5 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A GLU 175 OE1 ? ? ? 1_555 C ZN . ZN ? ? A GLU 438 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.306 ? ? 
metalc2 metalc ? ? A HIS 179 NE2 ? ? ? 1_555 C ZN . ZN ? ? A HIS 442 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.058 ? ? 
metalc3 metalc ? ? A CYS 184 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 447 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.270 ? ? 
metalc4 metalc ? ? A CYS 187 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 450 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.124 ? ? 
metalc5 metalc ? ? A HIS 449 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 712 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.070 ? ? 
metalc6 metalc ? ? A HIS 451 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 714 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.004 ? ? 
metalc7 metalc ? ? A CYS 465 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 728 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.337 ? ? 
metalc8 metalc ? ? A CYS 584 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 847 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.345 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 NE2 ? A HIS 179 ? A HIS 442 ? 1_555 117.6 ? 
2  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 106.1 ? 
3  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 119.8 ? 
4  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 78.8  ? 
5  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 114.1 ? 
6  SG  ? A CYS 184 ? A CYS 447 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 113.2 ? 
7  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 98.7  ? 
8  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 107.3 ? 
9  NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 105.9 ? 
10 NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 106.7 ? 
11 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 116.1 ? 
12 SG  ? A CYS 465 ? A CYS 728 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 119.8 ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 41  ? GLU A 47  ? ALA A 304 GLU A 310 
AA1 2 VAL A 326 ? ARG A 332 ? VAL A 589 ARG A 595 
AA1 3 LYS A 313 ? ARG A 319 ? LYS A 576 ARG A 582 
AA1 4 TYR A 189 ? ASN A 190 ? TYR A 452 ASN A 453 
AA2 1 MET A 57  ? VAL A 58  ? MET A 320 VAL A 321 
AA2 2 ILE A 477 ? SER A 478 ? ILE A 740 SER A 741 
AA3 1 MET A 395 ? SER A 398 ? MET A 658 SER A 661 
AA3 2 ASP A 401 ? VAL A 404 ? ASP A 664 VAL A 667 
AA4 1 HIS A 449 ? ILE A 454 ? HIS A 712 ILE A 717 
AA4 2 VAL A 460 ? CYS A 465 ? VAL A 723 CYS A 728 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N HIS A 43  ? N HIS A 306 O ILE A 329 ? O ILE A 592 
AA1 2 3 O VAL A 326 ? O VAL A 589 N ARG A 319 ? N ARG A 582 
AA1 3 4 O VAL A 314 ? O VAL A 577 N TYR A 189 ? N TYR A 452 
AA2 1 2 N MET A 57  ? N MET A 320 O SER A 478 ? O SER A 741 
AA3 1 2 N SER A 398 ? N SER A 661 O ASP A 401 ? O ASP A 664 
AA4 1 2 N LEU A 453 ? N LEU A 716 O LEU A 461 ? O LEU A 724 
# 
_pdbx_entry_details.entry_id                   7I2R 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 OD1 A ASP 664  ? ? O4 A PO4 1006 ? ? 2.10 
2 1 O   A HOH 1193 ? ? O  A HOH 1261 ? ? 2.15 
# 
loop_
_pdbx_validate_symm_contact.id 
_pdbx_validate_symm_contact.PDB_model_num 
_pdbx_validate_symm_contact.auth_atom_id_1 
_pdbx_validate_symm_contact.auth_asym_id_1 
_pdbx_validate_symm_contact.auth_comp_id_1 
_pdbx_validate_symm_contact.auth_seq_id_1 
_pdbx_validate_symm_contact.PDB_ins_code_1 
_pdbx_validate_symm_contact.label_alt_id_1 
_pdbx_validate_symm_contact.site_symmetry_1 
_pdbx_validate_symm_contact.auth_atom_id_2 
_pdbx_validate_symm_contact.auth_asym_id_2 
_pdbx_validate_symm_contact.auth_comp_id_2 
_pdbx_validate_symm_contact.auth_seq_id_2 
_pdbx_validate_symm_contact.PDB_ins_code_2 
_pdbx_validate_symm_contact.label_alt_id_2 
_pdbx_validate_symm_contact.site_symmetry_2 
_pdbx_validate_symm_contact.dist 
1 1 O A HOH 1248 ? ? 1_555 O A HOH 1342 ? ? 2_545 1.84 
2 1 O A HOH 1131 ? ? 1_555 O A HOH 1131 ? ? 2_445 1.98 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 SER A 291 ? ? -158.08 5.21   
2  1 PRO A 299 ? ? -93.53  35.51  
3  1 LYS A 420 ? ? -81.51  -80.01 
4  1 LEU A 504 ? ? 75.59   -40.96 
5  1 VAL A 507 ? ? -142.80 18.00  
6  1 ARG A 595 ? ? -170.32 145.17 
7  1 GLN A 598 ? ? 100.56  157.35 
8  1 SER A 601 ? ? 179.70  178.78 
9  1 LYS A 719 ? B -39.24  -36.94 
10 1 GLU A 807 ? ? -48.88  151.53 
11 1 ILE A 818 ? ? -113.82 -70.01 
# 
loop_
_pdbx_validate_main_chain_plane.id 
_pdbx_validate_main_chain_plane.PDB_model_num 
_pdbx_validate_main_chain_plane.auth_comp_id 
_pdbx_validate_main_chain_plane.auth_asym_id 
_pdbx_validate_main_chain_plane.auth_seq_id 
_pdbx_validate_main_chain_plane.PDB_ins_code 
_pdbx_validate_main_chain_plane.label_alt_id 
_pdbx_validate_main_chain_plane.improper_torsion_angle 
1 1 GLY A 511 ? ? -10.76 
2 1 GLY A 511 ? ? -10.43 
3 1 PRO A 784 ? ? -10.85 
4 1 PRO A 784 ? ? -11.01 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A MES 1003 ? D MES . 
2 1 A HOH 1177 ? L HOH . 
3 1 A HOH 1204 ? L HOH . 
4 1 A HOH 1378 ? L HOH . 
5 1 A HOH 1397 ? L HOH . 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 1401 ? 5.82 . 
2 1 O ? A HOH 1402 ? 5.95 . 
3 1 O ? A HOH 1403 ? 6.13 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 264 ? A GLY 1   
2  1 Y 1 A PRO 265 ? A PRO 2   
3  1 Y 1 A GLY 266 ? A GLY 3   
4  1 Y 1 A ILE 267 ? A ILE 4   
5  1 Y 1 A GLU 268 ? A GLU 5   
6  1 Y 1 A SER 269 ? A SER 6   
7  1 Y 1 A GLU 270 ? A GLU 7   
8  1 Y 1 A THR 271 ? A THR 8   
9  1 Y 1 A PRO 272 ? A PRO 9   
10 1 Y 1 A GLN 313 ? A GLN 50  
11 1 Y 1 A THR 314 ? A THR 51  
12 1 Y 1 A GLY 315 ? A GLY 52  
13 1 Y 1 A SER 316 ? A SER 53  
14 1 Y 1 A ALA 317 ? A ALA 54  
15 1 Y 1 A SER 318 ? A SER 55  
16 1 Y 1 A ASP 345 ? A ASP 82  
17 1 Y 1 A THR 346 ? A THR 83  
18 1 Y 1 A THR 347 ? A THR 84  
19 1 Y 1 A PRO 348 ? A PRO 85  
20 1 Y 1 A PHE 349 ? A PHE 86  
21 1 Y 1 A GLY 350 ? A GLY 87  
22 1 Y 1 A GLN 351 ? A GLN 88  
23 1 Y 1 A GLN 352 ? A GLN 89  
24 1 Y 1 A ARG 353 ? A ARG 90  
25 1 Y 1 A VAL 354 ? A VAL 91  
26 1 Y 1 A PHE 355 ? A PHE 92  
27 1 Y 1 A LYS 356 ? A LYS 93  
28 1 Y 1 A ALA 407 ? A ALA 144 
29 1 Y 1 A ALA 408 ? A ALA 145 
30 1 Y 1 A LEU 409 ? A LEU 146 
31 1 Y 1 A GLY 410 ? A GLY 147 
32 1 Y 1 A ALA 411 ? A ALA 148 
33 1 Y 1 A ILE 412 ? A ILE 149 
34 1 Y 1 A PHE 413 ? A PHE 150 
35 1 Y 1 A THR 414 ? A THR 151 
36 1 Y 1 A ASP 415 ? A ASP 152 
37 1 Y 1 A GLU 416 ? A GLU 153 
38 1 Y 1 A ASN 417 ? A ASN 154 
39 1 Y 1 A LYS 418 ? A LYS 155 
40 1 Y 1 A GLY 456 ? A GLY 193 
41 1 Y 1 A LYS 457 ? A LYS 194 
42 1 Y 1 A ARG 458 ? A ARG 195 
43 1 Y 1 A GLU 459 ? A GLU 196 
44 1 Y 1 A LYS 460 ? A LYS 197 
45 1 Y 1 A LYS 461 ? A LYS 198 
46 1 Y 1 A LEU 462 ? A LEU 199 
47 1 Y 1 A GLY 463 ? A GLY 200 
48 1 Y 1 A GLU 464 ? A GLU 201 
49 1 Y 1 A PHE 465 ? A PHE 202 
50 1 Y 1 A GLY 466 ? A GLY 203 
51 1 Y 1 A LYS 467 ? A LYS 204 
52 1 Y 1 A ALA 468 ? A ALA 205 
53 1 Y 1 A LYS 469 ? A LYS 206 
54 1 Y 1 A GLY 470 ? A GLY 207 
55 1 Y 1 A SER 471 ? A SER 208 
56 1 Y 1 A ARG 472 ? A ARG 209 
57 1 Y 1 A ALA 473 ? A ALA 210 
58 1 Y 1 A PRO 585 ? A PRO 322 
59 1 Y 1 A ARG 586 ? A ARG 323 
60 1 Y 1 A GLY 587 ? A GLY 324 
61 1 Y 1 A ARG 792 ? A ARG 529 
62 1 Y 1 A THR 793 ? A THR 530 
63 1 Y 1 A THR 794 ? A THR 531 
64 1 Y 1 A TRP 795 ? A TRP 532 
65 1 Y 1 A SER 796 ? A SER 533 
66 1 Y 1 A ILE 797 ? A ILE 534 
67 1 Y 1 A HIS 798 ? A HIS 535 
68 1 Y 1 A ALA 799 ? A ALA 536 
69 1 Y 1 A GLU 892 ? A GLU 629 
70 1 Y 1 A GLU 893 ? A GLU 630 
71 1 Y 1 A GLU 894 ? A GLU 631 
72 1 Y 1 A GLU 895 ? A GLU 632 
73 1 Y 1 A ALA 896 ? A ALA 633 
74 1 Y 1 A GLY 897 ? A GLY 634 
75 1 Y 1 A VAL 898 ? A VAL 635 
76 1 Y 1 A LEU 899 ? A LEU 636 
77 1 Y 1 A TRP 900 ? A TRP 637 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CL  CL   CL N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
DMS S    S  N N 89  
DMS O    O  N N 90  
DMS C1   C  N N 91  
DMS C2   C  N N 92  
DMS H11  H  N N 93  
DMS H12  H  N N 94  
DMS H13  H  N N 95  
DMS H21  H  N N 96  
DMS H22  H  N N 97  
DMS H23  H  N N 98  
GLN N    N  N N 99  
GLN CA   C  N S 100 
GLN C    C  N N 101 
GLN O    O  N N 102 
GLN CB   C  N N 103 
GLN CG   C  N N 104 
GLN CD   C  N N 105 
GLN OE1  O  N N 106 
GLN NE2  N  N N 107 
GLN OXT  O  N N 108 
GLN H    H  N N 109 
GLN H2   H  N N 110 
GLN HA   H  N N 111 
GLN HB2  H  N N 112 
GLN HB3  H  N N 113 
GLN HG2  H  N N 114 
GLN HG3  H  N N 115 
GLN HE21 H  N N 116 
GLN HE22 H  N N 117 
GLN HXT  H  N N 118 
GLU N    N  N N 119 
GLU CA   C  N S 120 
GLU C    C  N N 121 
GLU O    O  N N 122 
GLU CB   C  N N 123 
GLU CG   C  N N 124 
GLU CD   C  N N 125 
GLU OE1  O  N N 126 
GLU OE2  O  N N 127 
GLU OXT  O  N N 128 
GLU H    H  N N 129 
GLU H2   H  N N 130 
GLU HA   H  N N 131 
GLU HB2  H  N N 132 
GLU HB3  H  N N 133 
GLU HG2  H  N N 134 
GLU HG3  H  N N 135 
GLU HE2  H  N N 136 
GLU HXT  H  N N 137 
GLY N    N  N N 138 
GLY CA   C  N N 139 
GLY C    C  N N 140 
GLY O    O  N N 141 
GLY OXT  O  N N 142 
GLY H    H  N N 143 
GLY H2   H  N N 144 
GLY HA2  H  N N 145 
GLY HA3  H  N N 146 
GLY HXT  H  N N 147 
HIS N    N  N N 148 
HIS CA   C  N S 149 
HIS C    C  N N 150 
HIS O    O  N N 151 
HIS CB   C  N N 152 
HIS CG   C  Y N 153 
HIS ND1  N  Y N 154 
HIS CD2  C  Y N 155 
HIS CE1  C  Y N 156 
HIS NE2  N  Y N 157 
HIS OXT  O  N N 158 
HIS H    H  N N 159 
HIS H2   H  N N 160 
HIS HA   H  N N 161 
HIS HB2  H  N N 162 
HIS HB3  H  N N 163 
HIS HD1  H  N N 164 
HIS HD2  H  N N 165 
HIS HE1  H  N N 166 
HIS HE2  H  N N 167 
HIS HXT  H  N N 168 
HOH O    O  N N 169 
HOH H1   H  N N 170 
HOH H2   H  N N 171 
ILE N    N  N N 172 
ILE CA   C  N S 173 
ILE C    C  N N 174 
ILE O    O  N N 175 
ILE CB   C  N S 176 
ILE CG1  C  N N 177 
ILE CG2  C  N N 178 
ILE CD1  C  N N 179 
ILE OXT  O  N N 180 
ILE H    H  N N 181 
ILE H2   H  N N 182 
ILE HA   H  N N 183 
ILE HB   H  N N 184 
ILE HG12 H  N N 185 
ILE HG13 H  N N 186 
ILE HG21 H  N N 187 
ILE HG22 H  N N 188 
ILE HG23 H  N N 189 
ILE HD11 H  N N 190 
ILE HD12 H  N N 191 
ILE HD13 H  N N 192 
ILE HXT  H  N N 193 
JGP C10  C  N N 194 
JGP C13  C  N N 195 
JGP C15  C  N N 196 
JGP C17  C  N N 197 
JGP C01  C  Y N 198 
JGP C02  C  Y N 199 
JGP C03  C  Y N 200 
JGP C04  C  Y N 201 
JGP C05  C  Y N 202 
JGP C06  C  Y N 203 
JGP C07  C  N N 204 
JGP O08  O  N N 205 
JGP N09  N  N N 206 
JGP C11  C  N N 207 
JGP C12  C  N N 208 
JGP C14  C  N N 209 
JGP O16  O  N N 210 
JGP O18  O  N N 211 
JGP H101 H  N N 212 
JGP H102 H  N N 213 
JGP H132 H  N N 214 
JGP H131 H  N N 215 
JGP H152 H  N N 216 
JGP H151 H  N N 217 
JGP H171 H  N N 218 
JGP H172 H  N N 219 
JGP H011 H  N N 220 
JGP H021 H  N N 221 
JGP H051 H  N N 222 
JGP H111 H  N N 223 
JGP H112 H  N N 224 
JGP H121 H  N N 225 
JGP H122 H  N N 226 
JGP H142 H  N N 227 
JGP H141 H  N N 228 
LEU N    N  N N 229 
LEU CA   C  N S 230 
LEU C    C  N N 231 
LEU O    O  N N 232 
LEU CB   C  N N 233 
LEU CG   C  N N 234 
LEU CD1  C  N N 235 
LEU CD2  C  N N 236 
LEU OXT  O  N N 237 
LEU H    H  N N 238 
LEU H2   H  N N 239 
LEU HA   H  N N 240 
LEU HB2  H  N N 241 
LEU HB3  H  N N 242 
LEU HG   H  N N 243 
LEU HD11 H  N N 244 
LEU HD12 H  N N 245 
LEU HD13 H  N N 246 
LEU HD21 H  N N 247 
LEU HD22 H  N N 248 
LEU HD23 H  N N 249 
LEU HXT  H  N N 250 
LYS N    N  N N 251 
LYS CA   C  N S 252 
LYS C    C  N N 253 
LYS O    O  N N 254 
LYS CB   C  N N 255 
LYS CG   C  N N 256 
LYS CD   C  N N 257 
LYS CE   C  N N 258 
LYS NZ   N  N N 259 
LYS OXT  O  N N 260 
LYS H    H  N N 261 
LYS H2   H  N N 262 
LYS HA   H  N N 263 
LYS HB2  H  N N 264 
LYS HB3  H  N N 265 
LYS HG2  H  N N 266 
LYS HG3  H  N N 267 
LYS HD2  H  N N 268 
LYS HD3  H  N N 269 
LYS HE2  H  N N 270 
LYS HE3  H  N N 271 
LYS HZ1  H  N N 272 
LYS HZ2  H  N N 273 
LYS HZ3  H  N N 274 
LYS HXT  H  N N 275 
MES O1   O  N N 276 
MES C2   C  N N 277 
MES C3   C  N N 278 
MES N4   N  N N 279 
MES C5   C  N N 280 
MES C6   C  N N 281 
MES C7   C  N N 282 
MES C8   C  N N 283 
MES S    S  N N 284 
MES O1S  O  N N 285 
MES O2S  O  N N 286 
MES O3S  O  N N 287 
MES H21  H  N N 288 
MES H22  H  N N 289 
MES H31  H  N N 290 
MES H32  H  N N 291 
MES HN4  H  N N 292 
MES H51  H  N N 293 
MES H52  H  N N 294 
MES H61  H  N N 295 
MES H62  H  N N 296 
MES H71  H  N N 297 
MES H72  H  N N 298 
MES H81  H  N N 299 
MES H82  H  N N 300 
MET N    N  N N 301 
MET CA   C  N S 302 
MET C    C  N N 303 
MET O    O  N N 304 
MET CB   C  N N 305 
MET CG   C  N N 306 
MET SD   S  N N 307 
MET CE   C  N N 308 
MET OXT  O  N N 309 
MET H    H  N N 310 
MET H2   H  N N 311 
MET HA   H  N N 312 
MET HB2  H  N N 313 
MET HB3  H  N N 314 
MET HG2  H  N N 315 
MET HG3  H  N N 316 
MET HE1  H  N N 317 
MET HE2  H  N N 318 
MET HE3  H  N N 319 
MET HXT  H  N N 320 
PEG C1   C  N N 321 
PEG O1   O  N N 322 
PEG C2   C  N N 323 
PEG O2   O  N N 324 
PEG C3   C  N N 325 
PEG C4   C  N N 326 
PEG O4   O  N N 327 
PEG H11  H  N N 328 
PEG H12  H  N N 329 
PEG HO1  H  N N 330 
PEG H21  H  N N 331 
PEG H22  H  N N 332 
PEG H31  H  N N 333 
PEG H32  H  N N 334 
PEG H41  H  N N 335 
PEG H42  H  N N 336 
PEG HO4  H  N N 337 
PHE N    N  N N 338 
PHE CA   C  N S 339 
PHE C    C  N N 340 
PHE O    O  N N 341 
PHE CB   C  N N 342 
PHE CG   C  Y N 343 
PHE CD1  C  Y N 344 
PHE CD2  C  Y N 345 
PHE CE1  C  Y N 346 
PHE CE2  C  Y N 347 
PHE CZ   C  Y N 348 
PHE OXT  O  N N 349 
PHE H    H  N N 350 
PHE H2   H  N N 351 
PHE HA   H  N N 352 
PHE HB2  H  N N 353 
PHE HB3  H  N N 354 
PHE HD1  H  N N 355 
PHE HD2  H  N N 356 
PHE HE1  H  N N 357 
PHE HE2  H  N N 358 
PHE HZ   H  N N 359 
PHE HXT  H  N N 360 
PO4 P    P  N N 361 
PO4 O1   O  N N 362 
PO4 O2   O  N N 363 
PO4 O3   O  N N 364 
PO4 O4   O  N N 365 
PRO N    N  N N 366 
PRO CA   C  N S 367 
PRO C    C  N N 368 
PRO O    O  N N 369 
PRO CB   C  N N 370 
PRO CG   C  N N 371 
PRO CD   C  N N 372 
PRO OXT  O  N N 373 
PRO H    H  N N 374 
PRO HA   H  N N 375 
PRO HB2  H  N N 376 
PRO HB3  H  N N 377 
PRO HG2  H  N N 378 
PRO HG3  H  N N 379 
PRO HD2  H  N N 380 
PRO HD3  H  N N 381 
PRO HXT  H  N N 382 
SER N    N  N N 383 
SER CA   C  N S 384 
SER C    C  N N 385 
SER O    O  N N 386 
SER CB   C  N N 387 
SER OG   O  N N 388 
SER OXT  O  N N 389 
SER H    H  N N 390 
SER H2   H  N N 391 
SER HA   H  N N 392 
SER HB2  H  N N 393 
SER HB3  H  N N 394 
SER HG   H  N N 395 
SER HXT  H  N N 396 
THR N    N  N N 397 
THR CA   C  N S 398 
THR C    C  N N 399 
THR O    O  N N 400 
THR CB   C  N R 401 
THR OG1  O  N N 402 
THR CG2  C  N N 403 
THR OXT  O  N N 404 
THR H    H  N N 405 
THR H2   H  N N 406 
THR HA   H  N N 407 
THR HB   H  N N 408 
THR HG1  H  N N 409 
THR HG21 H  N N 410 
THR HG22 H  N N 411 
THR HG23 H  N N 412 
THR HXT  H  N N 413 
TRP N    N  N N 414 
TRP CA   C  N S 415 
TRP C    C  N N 416 
TRP O    O  N N 417 
TRP CB   C  N N 418 
TRP CG   C  Y N 419 
TRP CD1  C  Y N 420 
TRP CD2  C  Y N 421 
TRP NE1  N  Y N 422 
TRP CE2  C  Y N 423 
TRP CE3  C  Y N 424 
TRP CZ2  C  Y N 425 
TRP CZ3  C  Y N 426 
TRP CH2  C  Y N 427 
TRP OXT  O  N N 428 
TRP H    H  N N 429 
TRP H2   H  N N 430 
TRP HA   H  N N 431 
TRP HB2  H  N N 432 
TRP HB3  H  N N 433 
TRP HD1  H  N N 434 
TRP HE1  H  N N 435 
TRP HE3  H  N N 436 
TRP HZ2  H  N N 437 
TRP HZ3  H  N N 438 
TRP HH2  H  N N 439 
TRP HXT  H  N N 440 
TYR N    N  N N 441 
TYR CA   C  N S 442 
TYR C    C  N N 443 
TYR O    O  N N 444 
TYR CB   C  N N 445 
TYR CG   C  Y N 446 
TYR CD1  C  Y N 447 
TYR CD2  C  Y N 448 
TYR CE1  C  Y N 449 
TYR CE2  C  Y N 450 
TYR CZ   C  Y N 451 
TYR OH   O  N N 452 
TYR OXT  O  N N 453 
TYR H    H  N N 454 
TYR H2   H  N N 455 
TYR HA   H  N N 456 
TYR HB2  H  N N 457 
TYR HB3  H  N N 458 
TYR HD1  H  N N 459 
TYR HD2  H  N N 460 
TYR HE1  H  N N 461 
TYR HE2  H  N N 462 
TYR HH   H  N N 463 
TYR HXT  H  N N 464 
VAL N    N  N N 465 
VAL CA   C  N S 466 
VAL C    C  N N 467 
VAL O    O  N N 468 
VAL CB   C  N N 469 
VAL CG1  C  N N 470 
VAL CG2  C  N N 471 
VAL OXT  O  N N 472 
VAL H    H  N N 473 
VAL H2   H  N N 474 
VAL HA   H  N N 475 
VAL HB   H  N N 476 
VAL HG11 H  N N 477 
VAL HG12 H  N N 478 
VAL HG13 H  N N 479 
VAL HG21 H  N N 480 
VAL HG22 H  N N 481 
VAL HG23 H  N N 482 
VAL HXT  H  N N 483 
ZN  ZN   ZN N N 484 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
DMS S   O    doub N N 83  
DMS S   C1   sing N N 84  
DMS S   C2   sing N N 85  
DMS C1  H11  sing N N 86  
DMS C1  H12  sing N N 87  
DMS C1  H13  sing N N 88  
DMS C2  H21  sing N N 89  
DMS C2  H22  sing N N 90  
DMS C2  H23  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
HIS N   CA   sing N N 138 
HIS N   H    sing N N 139 
HIS N   H2   sing N N 140 
HIS CA  C    sing N N 141 
HIS CA  CB   sing N N 142 
HIS CA  HA   sing N N 143 
HIS C   O    doub N N 144 
HIS C   OXT  sing N N 145 
HIS CB  CG   sing N N 146 
HIS CB  HB2  sing N N 147 
HIS CB  HB3  sing N N 148 
HIS CG  ND1  sing Y N 149 
HIS CG  CD2  doub Y N 150 
HIS ND1 CE1  doub Y N 151 
HIS ND1 HD1  sing N N 152 
HIS CD2 NE2  sing Y N 153 
HIS CD2 HD2  sing N N 154 
HIS CE1 NE2  sing Y N 155 
HIS CE1 HE1  sing N N 156 
HIS NE2 HE2  sing N N 157 
HIS OXT HXT  sing N N 158 
HOH O   H1   sing N N 159 
HOH O   H2   sing N N 160 
ILE N   CA   sing N N 161 
ILE N   H    sing N N 162 
ILE N   H2   sing N N 163 
ILE CA  C    sing N N 164 
ILE CA  CB   sing N N 165 
ILE CA  HA   sing N N 166 
ILE C   O    doub N N 167 
ILE C   OXT  sing N N 168 
ILE CB  CG1  sing N N 169 
ILE CB  CG2  sing N N 170 
ILE CB  HB   sing N N 171 
ILE CG1 CD1  sing N N 172 
ILE CG1 HG12 sing N N 173 
ILE CG1 HG13 sing N N 174 
ILE CG2 HG21 sing N N 175 
ILE CG2 HG22 sing N N 176 
ILE CG2 HG23 sing N N 177 
ILE CD1 HD11 sing N N 178 
ILE CD1 HD12 sing N N 179 
ILE CD1 HD13 sing N N 180 
ILE OXT HXT  sing N N 181 
JGP C14 C15  sing N N 182 
JGP C14 C13  sing N N 183 
JGP C15 N09  sing N N 184 
JGP C11 C10  sing N N 185 
JGP C11 C12  sing N N 186 
JGP C13 C12  sing N N 187 
JGP C10 N09  sing N N 188 
JGP N09 C07  sing N N 189 
JGP O16 C04  sing N N 190 
JGP O16 C17  sing N N 191 
JGP C05 C04  doub Y N 192 
JGP C05 C06  sing Y N 193 
JGP C07 C06  sing N N 194 
JGP C07 O08  doub N N 195 
JGP C04 C03  sing Y N 196 
JGP C06 C01  doub Y N 197 
JGP C17 O18  sing N N 198 
JGP C03 O18  sing N N 199 
JGP C03 C02  doub Y N 200 
JGP C01 C02  sing Y N 201 
JGP C10 H101 sing N N 202 
JGP C10 H102 sing N N 203 
JGP C13 H132 sing N N 204 
JGP C13 H131 sing N N 205 
JGP C15 H152 sing N N 206 
JGP C15 H151 sing N N 207 
JGP C17 H171 sing N N 208 
JGP C17 H172 sing N N 209 
JGP C01 H011 sing N N 210 
JGP C02 H021 sing N N 211 
JGP C05 H051 sing N N 212 
JGP C11 H111 sing N N 213 
JGP C11 H112 sing N N 214 
JGP C12 H121 sing N N 215 
JGP C12 H122 sing N N 216 
JGP C14 H142 sing N N 217 
JGP C14 H141 sing N N 218 
LEU N   CA   sing N N 219 
LEU N   H    sing N N 220 
LEU N   H2   sing N N 221 
LEU CA  C    sing N N 222 
LEU CA  CB   sing N N 223 
LEU CA  HA   sing N N 224 
LEU C   O    doub N N 225 
LEU C   OXT  sing N N 226 
LEU CB  CG   sing N N 227 
LEU CB  HB2  sing N N 228 
LEU CB  HB3  sing N N 229 
LEU CG  CD1  sing N N 230 
LEU CG  CD2  sing N N 231 
LEU CG  HG   sing N N 232 
LEU CD1 HD11 sing N N 233 
LEU CD1 HD12 sing N N 234 
LEU CD1 HD13 sing N N 235 
LEU CD2 HD21 sing N N 236 
LEU CD2 HD22 sing N N 237 
LEU CD2 HD23 sing N N 238 
LEU OXT HXT  sing N N 239 
LYS N   CA   sing N N 240 
LYS N   H    sing N N 241 
LYS N   H2   sing N N 242 
LYS CA  C    sing N N 243 
LYS CA  CB   sing N N 244 
LYS CA  HA   sing N N 245 
LYS C   O    doub N N 246 
LYS C   OXT  sing N N 247 
LYS CB  CG   sing N N 248 
LYS CB  HB2  sing N N 249 
LYS CB  HB3  sing N N 250 
LYS CG  CD   sing N N 251 
LYS CG  HG2  sing N N 252 
LYS CG  HG3  sing N N 253 
LYS CD  CE   sing N N 254 
LYS CD  HD2  sing N N 255 
LYS CD  HD3  sing N N 256 
LYS CE  NZ   sing N N 257 
LYS CE  HE2  sing N N 258 
LYS CE  HE3  sing N N 259 
LYS NZ  HZ1  sing N N 260 
LYS NZ  HZ2  sing N N 261 
LYS NZ  HZ3  sing N N 262 
LYS OXT HXT  sing N N 263 
MES O1  C2   sing N N 264 
MES O1  C6   sing N N 265 
MES C2  C3   sing N N 266 
MES C2  H21  sing N N 267 
MES C2  H22  sing N N 268 
MES C3  N4   sing N N 269 
MES C3  H31  sing N N 270 
MES C3  H32  sing N N 271 
MES N4  C5   sing N N 272 
MES N4  C7   sing N N 273 
MES N4  HN4  sing N N 274 
MES C5  C6   sing N N 275 
MES C5  H51  sing N N 276 
MES C5  H52  sing N N 277 
MES C6  H61  sing N N 278 
MES C6  H62  sing N N 279 
MES C7  C8   sing N N 280 
MES C7  H71  sing N N 281 
MES C7  H72  sing N N 282 
MES C8  S    sing N N 283 
MES C8  H81  sing N N 284 
MES C8  H82  sing N N 285 
MES S   O1S  doub N N 286 
MES S   O2S  doub N N 287 
MES S   O3S  sing N N 288 
MET N   CA   sing N N 289 
MET N   H    sing N N 290 
MET N   H2   sing N N 291 
MET CA  C    sing N N 292 
MET CA  CB   sing N N 293 
MET CA  HA   sing N N 294 
MET C   O    doub N N 295 
MET C   OXT  sing N N 296 
MET CB  CG   sing N N 297 
MET CB  HB2  sing N N 298 
MET CB  HB3  sing N N 299 
MET CG  SD   sing N N 300 
MET CG  HG2  sing N N 301 
MET CG  HG3  sing N N 302 
MET SD  CE   sing N N 303 
MET CE  HE1  sing N N 304 
MET CE  HE2  sing N N 305 
MET CE  HE3  sing N N 306 
MET OXT HXT  sing N N 307 
PEG C1  O1   sing N N 308 
PEG C1  C2   sing N N 309 
PEG C1  H11  sing N N 310 
PEG C1  H12  sing N N 311 
PEG O1  HO1  sing N N 312 
PEG C2  O2   sing N N 313 
PEG C2  H21  sing N N 314 
PEG C2  H22  sing N N 315 
PEG O2  C3   sing N N 316 
PEG C3  C4   sing N N 317 
PEG C3  H31  sing N N 318 
PEG C3  H32  sing N N 319 
PEG C4  O4   sing N N 320 
PEG C4  H41  sing N N 321 
PEG C4  H42  sing N N 322 
PEG O4  HO4  sing N N 323 
PHE N   CA   sing N N 324 
PHE N   H    sing N N 325 
PHE N   H2   sing N N 326 
PHE CA  C    sing N N 327 
PHE CA  CB   sing N N 328 
PHE CA  HA   sing N N 329 
PHE C   O    doub N N 330 
PHE C   OXT  sing N N 331 
PHE CB  CG   sing N N 332 
PHE CB  HB2  sing N N 333 
PHE CB  HB3  sing N N 334 
PHE CG  CD1  doub Y N 335 
PHE CG  CD2  sing Y N 336 
PHE CD1 CE1  sing Y N 337 
PHE CD1 HD1  sing N N 338 
PHE CD2 CE2  doub Y N 339 
PHE CD2 HD2  sing N N 340 
PHE CE1 CZ   doub Y N 341 
PHE CE1 HE1  sing N N 342 
PHE CE2 CZ   sing Y N 343 
PHE CE2 HE2  sing N N 344 
PHE CZ  HZ   sing N N 345 
PHE OXT HXT  sing N N 346 
PO4 P   O1   doub N N 347 
PO4 P   O2   sing N N 348 
PO4 P   O3   sing N N 349 
PO4 P   O4   sing N N 350 
PRO N   CA   sing N N 351 
PRO N   CD   sing N N 352 
PRO N   H    sing N N 353 
PRO CA  C    sing N N 354 
PRO CA  CB   sing N N 355 
PRO CA  HA   sing N N 356 
PRO C   O    doub N N 357 
PRO C   OXT  sing N N 358 
PRO CB  CG   sing N N 359 
PRO CB  HB2  sing N N 360 
PRO CB  HB3  sing N N 361 
PRO CG  CD   sing N N 362 
PRO CG  HG2  sing N N 363 
PRO CG  HG3  sing N N 364 
PRO CD  HD2  sing N N 365 
PRO CD  HD3  sing N N 366 
PRO OXT HXT  sing N N 367 
SER N   CA   sing N N 368 
SER N   H    sing N N 369 
SER N   H2   sing N N 370 
SER CA  C    sing N N 371 
SER CA  CB   sing N N 372 
SER CA  HA   sing N N 373 
SER C   O    doub N N 374 
SER C   OXT  sing N N 375 
SER CB  OG   sing N N 376 
SER CB  HB2  sing N N 377 
SER CB  HB3  sing N N 378 
SER OG  HG   sing N N 379 
SER OXT HXT  sing N N 380 
THR N   CA   sing N N 381 
THR N   H    sing N N 382 
THR N   H2   sing N N 383 
THR CA  C    sing N N 384 
THR CA  CB   sing N N 385 
THR CA  HA   sing N N 386 
THR C   O    doub N N 387 
THR C   OXT  sing N N 388 
THR CB  OG1  sing N N 389 
THR CB  CG2  sing N N 390 
THR CB  HB   sing N N 391 
THR OG1 HG1  sing N N 392 
THR CG2 HG21 sing N N 393 
THR CG2 HG22 sing N N 394 
THR CG2 HG23 sing N N 395 
THR OXT HXT  sing N N 396 
TRP N   CA   sing N N 397 
TRP N   H    sing N N 398 
TRP N   H2   sing N N 399 
TRP CA  C    sing N N 400 
TRP CA  CB   sing N N 401 
TRP CA  HA   sing N N 402 
TRP C   O    doub N N 403 
TRP C   OXT  sing N N 404 
TRP CB  CG   sing N N 405 
TRP CB  HB2  sing N N 406 
TRP CB  HB3  sing N N 407 
TRP CG  CD1  doub Y N 408 
TRP CG  CD2  sing Y N 409 
TRP CD1 NE1  sing Y N 410 
TRP CD1 HD1  sing N N 411 
TRP CD2 CE2  doub Y N 412 
TRP CD2 CE3  sing Y N 413 
TRP NE1 CE2  sing Y N 414 
TRP NE1 HE1  sing N N 415 
TRP CE2 CZ2  sing Y N 416 
TRP CE3 CZ3  doub Y N 417 
TRP CE3 HE3  sing N N 418 
TRP CZ2 CH2  doub Y N 419 
TRP CZ2 HZ2  sing N N 420 
TRP CZ3 CH2  sing Y N 421 
TRP CZ3 HZ3  sing N N 422 
TRP CH2 HH2  sing N N 423 
TRP OXT HXT  sing N N 424 
TYR N   CA   sing N N 425 
TYR N   H    sing N N 426 
TYR N   H2   sing N N 427 
TYR CA  C    sing N N 428 
TYR CA  CB   sing N N 429 
TYR CA  HA   sing N N 430 
TYR C   O    doub N N 431 
TYR C   OXT  sing N N 432 
TYR CB  CG   sing N N 433 
TYR CB  HB2  sing N N 434 
TYR CB  HB3  sing N N 435 
TYR CG  CD1  doub Y N 436 
TYR CG  CD2  sing Y N 437 
TYR CD1 CE1  sing Y N 438 
TYR CD1 HD1  sing N N 439 
TYR CD2 CE2  doub Y N 440 
TYR CD2 HD2  sing N N 441 
TYR CE1 CZ   doub Y N 442 
TYR CE1 HE1  sing N N 443 
TYR CE2 CZ   sing Y N 444 
TYR CE2 HE2  sing N N 445 
TYR CZ  OH   sing N N 446 
TYR OH  HH   sing N N 447 
TYR OXT HXT  sing N N 448 
VAL N   CA   sing N N 449 
VAL N   H    sing N N 450 
VAL N   H2   sing N N 451 
VAL CA  C    sing N N 452 
VAL CA  CB   sing N N 453 
VAL CA  HA   sing N N 454 
VAL C   O    doub N N 455 
VAL C   OXT  sing N N 456 
VAL CB  CG1  sing N N 457 
VAL CB  CG2  sing N N 458 
VAL CB  HB   sing N N 459 
VAL CG1 HG11 sing N N 460 
VAL CG1 HG12 sing N N 461 
VAL CG1 HG13 sing N N 462 
VAL CG2 HG21 sing N N 463 
VAL CG2 HG22 sing N N 464 
VAL CG2 HG23 sing N N 465 
VAL OXT HXT  sing N N 466 
# 
_pdbx_audit_support.ordinal                1 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)' 
_pdbx_audit_support.grant_number           U19AI171292 
_pdbx_audit_support.country                'United States' 
# 
_pdbx_deposit_group.group_id            G_1002341 
_pdbx_deposit_group.group_description   
'Crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_title         
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_type          'changed state' 
# 
_atom_sites.entry_id                    7I2R 
_atom_sites.fract_transf_matrix[1][1]   0.012206 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.008624 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006730 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
# 
loop_
_atom_type.symbol 
C  
CL 
N  
O  
P  
S  
ZN 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ASN A 1 10  ? -13.342 -5.742  -12.580 0.56 107.59 ? 273  ASN A N   1 
ATOM   2    C  CA  . ASN A 1 10  ? -13.194 -6.693  -11.439 0.56 107.12 ? 273  ASN A CA  1 
ATOM   3    C  C   . ASN A 1 10  ? -14.439 -6.598  -10.546 0.56 104.02 ? 273  ASN A C   1 
ATOM   4    O  O   . ASN A 1 10  ? -15.477 -7.175  -10.931 0.56 100.57 ? 273  ASN A O   1 
ATOM   5    C  CB  . ASN A 1 10  ? -11.900 -6.438  -10.658 0.56 108.35 ? 273  ASN A CB  1 
ATOM   6    C  CG  . ASN A 1 10  ? -11.665 -7.439  -9.546  0.56 110.02 ? 273  ASN A CG  1 
ATOM   7    O  OD1 . ASN A 1 10  ? -12.289 -8.497  -9.514  0.56 114.92 ? 273  ASN A OD1 1 
ATOM   8    N  ND2 . ASN A 1 10  ? -10.759 -7.120  -8.635  0.56 109.28 ? 273  ASN A ND2 1 
ATOM   9    N  N   . LEU A 1 11  ? -14.337 -5.893  -9.411  0.50 102.05 ? 274  LEU A N   1 
ATOM   10   C  CA  . LEU A 1 11  ? -15.392 -5.811  -8.361  0.50 98.85  ? 274  LEU A CA  1 
ATOM   11   C  C   . LEU A 1 11  ? -16.669 -5.207  -8.954  0.50 95.45  ? 274  LEU A C   1 
ATOM   12   O  O   . LEU A 1 11  ? -17.755 -5.467  -8.398  0.50 90.00  ? 274  LEU A O   1 
ATOM   13   C  CB  . LEU A 1 11  ? -14.881 -4.977  -7.182  0.50 102.56 ? 274  LEU A CB  1 
ATOM   14   C  CG  . LEU A 1 11  ? -13.944 -5.707  -6.220  0.50 106.81 ? 274  LEU A CG  1 
ATOM   15   C  CD1 . LEU A 1 11  ? -13.447 -4.772  -5.128  0.50 109.78 ? 274  LEU A CD1 1 
ATOM   16   C  CD2 . LEU A 1 11  ? -14.629 -6.920  -5.608  0.50 106.86 ? 274  LEU A CD2 1 
ATOM   17   N  N   . ASP A 1 12  ? -16.537 -4.440  -10.040 0.50 93.40  ? 275  ASP A N   1 
ATOM   18   C  CA  . ASP A 1 12  ? -17.676 -3.843  -10.787 0.50 96.23  ? 275  ASP A CA  1 
ATOM   19   C  C   . ASP A 1 12  ? -18.567 -4.967  -11.335 0.50 93.84  ? 275  ASP A C   1 
ATOM   20   O  O   . ASP A 1 12  ? -19.778 -4.723  -11.502 0.50 91.30  ? 275  ASP A O   1 
ATOM   21   C  CB  . ASP A 1 12  ? -17.189 -2.931  -11.917 0.50 99.38  ? 275  ASP A CB  1 
ATOM   22   C  CG  . ASP A 1 12  ? -16.422 -3.661  -13.007 0.50 105.67 ? 275  ASP A CG  1 
ATOM   23   O  OD1 . ASP A 1 12  ? -15.695 -4.619  -12.671 0.50 109.79 ? 275  ASP A OD1 1 
ATOM   24   O  OD2 . ASP A 1 12  ? -16.561 -3.268  -14.184 0.50 111.05 ? 275  ASP A OD2 1 
ATOM   25   N  N   . ILE A 1 13  ? -17.984 -6.145  -11.599 0.50 88.65  ? 276  ILE A N   1 
ATOM   26   C  CA  . ILE A 1 13  ? -18.665 -7.309  -12.246 0.50 80.93  ? 276  ILE A CA  1 
ATOM   27   C  C   . ILE A 1 13  ? -19.004 -8.365  -11.188 0.50 76.21  ? 276  ILE A C   1 
ATOM   28   O  O   . ILE A 1 13  ? -20.003 -9.082  -11.370 0.50 69.03  ? 276  ILE A O   1 
ATOM   29   C  CB  . ILE A 1 13  ? -17.791 -7.897  -13.372 0.50 82.24  ? 276  ILE A CB  1 
ATOM   30   C  CG1 . ILE A 1 13  ? -17.674 -6.931  -14.554 0.50 80.02  ? 276  ILE A CG1 1 
ATOM   31   C  CG2 . ILE A 1 13  ? -18.316 -9.261  -13.799 0.50 82.12  ? 276  ILE A CG2 1 
ATOM   32   C  CD1 . ILE A 1 13  ? -16.837 -7.453  -15.700 0.50 79.98  ? 276  ILE A CD1 1 
ATOM   33   N  N   . ILE A 1 14  ? -18.213 -8.447  -10.118 0.50 76.78  ? 277  ILE A N   1 
ATOM   34   C  CA  . ILE A 1 14  ? -18.330 -9.515  -9.081  0.50 78.87  ? 277  ILE A CA  1 
ATOM   35   C  C   . ILE A 1 14  ? -18.886 -8.917  -7.783  0.50 80.01  ? 277  ILE A C   1 
ATOM   36   O  O   . ILE A 1 14  ? -19.483 -9.678  -6.992  0.50 78.36  ? 277  ILE A O   1 
ATOM   37   C  CB  . ILE A 1 14  ? -16.965 -10.199 -8.873  0.50 81.79  ? 277  ILE A CB  1 
ATOM   38   C  CG1 . ILE A 1 14  ? -15.940 -9.248  -8.249  0.50 80.59  ? 277  ILE A CG1 1 
ATOM   39   C  CG2 . ILE A 1 14  ? -16.460 -10.789 -10.182 0.50 81.06  ? 277  ILE A CG2 1 
ATOM   40   C  CD1 . ILE A 1 14  ? -14.660 -9.929  -7.820  0.50 81.52  ? 277  ILE A CD1 1 
ATOM   41   N  N   . GLY A 1 15  ? -18.699 -7.609  -7.576  0.50 87.20  ? 278  GLY A N   1 
ATOM   42   C  CA  . GLY A 1 15  ? -19.164 -6.881  -6.378  0.50 88.32  ? 278  GLY A CA  1 
ATOM   43   C  C   . GLY A 1 15  ? -20.591 -7.255  -6.004  0.50 89.06  ? 278  GLY A C   1 
ATOM   44   O  O   . GLY A 1 15  ? -20.791 -7.810  -4.901  0.50 88.30  ? 278  GLY A O   1 
ATOM   45   N  N   . LYS A 1 16  ? -21.548 -6.967  -6.893  0.50 88.41  ? 279  LYS A N   1 
ATOM   46   C  CA  . LYS A 1 16  ? -23.000 -7.208  -6.677  0.50 89.01  ? 279  LYS A CA  1 
ATOM   47   C  C   . LYS A 1 16  ? -23.191 -8.609  -6.085  0.50 85.40  ? 279  LYS A C   1 
ATOM   48   O  O   . LYS A 1 16  ? -23.901 -8.735  -5.067  0.50 80.11  ? 279  LYS A O   1 
ATOM   49   C  CB  . LYS A 1 16  ? -23.765 -7.042  -7.994  0.50 92.24  ? 279  LYS A CB  1 
ATOM   50   C  CG  . LYS A 1 16  ? -25.282 -7.135  -7.881  0.50 95.54  ? 279  LYS A CG  1 
ATOM   51   C  CD  . LYS A 1 16  ? -26.007 -6.790  -9.168  0.50 98.84  ? 279  LYS A CD  1 
ATOM   52   C  CE  . LYS A 1 16  ? -27.513 -6.897  -9.054  0.50 100.09 ? 279  LYS A CE  1 
ATOM   53   N  NZ  . LYS A 1 16  ? -28.048 -6.000  -8.003  0.50 101.71 ? 279  LYS A NZ  1 
ATOM   54   N  N   . ARG A 1 17  ? -22.574 -9.615  -6.706  0.50 85.18  ? 280  ARG A N   1 
ATOM   55   C  CA  . ARG A 1 17  ? -22.689 -11.013 -6.217  0.50 84.96  ? 280  ARG A CA  1 
ATOM   56   C  C   . ARG A 1 17  ? -22.067 -11.110 -4.824  0.50 84.39  ? 280  ARG A C   1 
ATOM   57   O  O   . ARG A 1 17  ? -22.704 -11.699 -3.933  0.50 82.35  ? 280  ARG A O   1 
ATOM   58   C  CB  . ARG A 1 17  ? -21.981 -11.967 -7.182  0.50 84.38  ? 280  ARG A CB  1 
ATOM   59   C  CG  . ARG A 1 17  ? -22.827 -12.401 -8.370  0.50 82.99  ? 280  ARG A CG  1 
ATOM   60   C  CD  . ARG A 1 17  ? -22.044 -13.235 -9.365  0.50 77.82  ? 280  ARG A CD  1 
ATOM   61   N  NE  . ARG A 1 17  ? -21.189 -12.409 -10.204 0.50 75.02  ? 280  ARG A NE  1 
ATOM   62   C  CZ  . ARG A 1 17  ? -20.422 -12.870 -11.183 0.50 73.05  ? 280  ARG A CZ  1 
ATOM   63   N  NH1 . ARG A 1 17  ? -20.394 -14.164 -11.450 0.50 72.72  ? 280  ARG A NH1 1 
ATOM   64   N  NH2 . ARG A 1 17  ? -19.685 -12.035 -11.892 0.50 72.68  ? 280  ARG A NH2 1 
ATOM   65   N  N   . ILE A 1 18  ? -20.863 -10.558 -4.658  0.50 86.28  ? 281  ILE A N   1 
ATOM   66   C  CA  . ILE A 1 18  ? -20.156 -10.641 -3.347  0.50 89.02  ? 281  ILE A CA  1 
ATOM   67   C  C   . ILE A 1 18  ? -20.989 -9.895  -2.301  0.50 89.08  ? 281  ILE A C   1 
ATOM   68   O  O   . ILE A 1 18  ? -21.166 -10.437 -1.194  0.50 87.03  ? 281  ILE A O   1 
ATOM   69   C  CB  . ILE A 1 18  ? -18.729 -10.073 -3.466  0.50 90.57  ? 281  ILE A CB  1 
ATOM   70   C  CG1 . ILE A 1 18  ? -17.925 -10.802 -4.544  0.50 92.70  ? 281  ILE A CG1 1 
ATOM   71   C  CG2 . ILE A 1 18  ? -18.022 -10.102 -2.121  0.50 90.81  ? 281  ILE A CG2 1 
ATOM   72   C  CD1 . ILE A 1 18  ? -16.561 -10.210 -4.796  0.50 93.45  ? 281  ILE A CD1 1 
ATOM   73   N  N   . GLU A 1 19  ? -21.505 -8.718  -2.658  0.50 89.07  ? 282  GLU A N   1 
ATOM   74   C  CA  . GLU A 1 19  ? -22.285 -7.897  -1.694  0.50 89.48  ? 282  GLU A CA  1 
ATOM   75   C  C   . GLU A 1 19  ? -23.517 -8.680  -1.238  0.50 85.53  ? 282  GLU A C   1 
ATOM   76   O  O   . GLU A 1 19  ? -23.812 -8.659  -0.028  0.50 81.54  ? 282  GLU A O   1 
ATOM   77   C  CB  . GLU A 1 19  ? -22.674 -6.568  -2.340  0.50 91.77  ? 282  GLU A CB  1 
ATOM   78   C  CG  . GLU A 1 19  ? -21.480 -5.759  -2.808  0.50 94.99  ? 282  GLU A CG  1 
ATOM   79   C  CD  . GLU A 1 19  ? -21.830 -4.494  -3.571  0.50 96.66  ? 282  GLU A CD  1 
ATOM   80   O  OE1 . GLU A 1 19  ? -23.031 -4.167  -3.649  0.50 96.35  ? 282  GLU A OE1 1 
ATOM   81   O  OE2 . GLU A 1 19  ? -20.902 -3.841  -4.086  0.50 95.04  ? 282  GLU A OE2 1 
ATOM   82   N  N   . LYS A 1 20  ? -24.190 -9.362  -2.167  0.56 85.13  ? 283  LYS A N   1 
ATOM   83   C  CA  . LYS A 1 20  ? -25.436 -10.097 -1.824  0.56 84.46  ? 283  LYS A CA  1 
ATOM   84   C  C   . LYS A 1 20  ? -25.127 -11.191 -0.801  0.56 83.54  ? 283  LYS A C   1 
ATOM   85   O  O   . LYS A 1 20  ? -25.865 -11.288 0.196   0.56 82.95  ? 283  LYS A O   1 
ATOM   86   C  CB  . LYS A 1 20  ? -26.052 -10.708 -3.084  0.56 84.97  ? 283  LYS A CB  1 
ATOM   87   C  CG  . LYS A 1 20  ? -27.364 -11.454 -2.889  0.56 84.05  ? 283  LYS A CG  1 
ATOM   88   C  CD  . LYS A 1 20  ? -28.032 -11.811 -4.200  0.56 84.90  ? 283  LYS A CD  1 
ATOM   89   C  CE  . LYS A 1 20  ? -29.368 -12.504 -4.034  0.56 84.50  ? 283  LYS A CE  1 
ATOM   90   N  NZ  . LYS A 1 20  ? -29.218 -13.860 -3.455  0.56 83.27  ? 283  LYS A NZ  1 
ATOM   91   N  N   . ILE A 1 21  ? -24.068 -11.966 -1.033  0.56 81.44  ? 284  ILE A N   1 
ATOM   92   C  CA  . ILE A 1 21  ? -23.760 -13.111 -0.129  0.56 84.14  ? 284  ILE A CA  1 
ATOM   93   C  C   . ILE A 1 21  ? -23.425 -12.571 1.263   0.56 81.91  ? 284  ILE A C   1 
ATOM   94   O  O   . ILE A 1 21  ? -23.900 -13.153 2.255   0.56 77.92  ? 284  ILE A O   1 
ATOM   95   C  CB  . ILE A 1 21  ? -22.607 -13.954 -0.707  0.56 84.56  ? 284  ILE A CB  1 
ATOM   96   C  CG1 . ILE A 1 21  ? -22.902 -14.407 -2.139  0.56 83.67  ? 284  ILE A CG1 1 
ATOM   97   C  CG2 . ILE A 1 21  ? -22.287 -15.129 0.205   0.56 83.39  ? 284  ILE A CG2 1 
ATOM   98   C  CD1 . ILE A 1 21  ? -21.740 -15.093 -2.818  0.56 81.11  ? 284  ILE A CD1 1 
ATOM   99   N  N   . LYS A 1 22  ? -22.637 -11.500 1.324   0.56 84.02  ? 285  LYS A N   1 
ATOM   100  C  CA  . LYS A 1 22  ? -22.219 -10.936 2.632   0.56 90.30  ? 285  LYS A CA  1 
ATOM   101  C  C   . LYS A 1 22  ? -23.461 -10.531 3.423   0.56 90.49  ? 285  LYS A C   1 
ATOM   102  O  O   . LYS A 1 22  ? -23.568 -10.929 4.594   0.56 84.29  ? 285  LYS A O   1 
ATOM   103  C  CB  . LYS A 1 22  ? -21.317 -9.722  2.405   0.56 95.83  ? 285  LYS A CB  1 
ATOM   104  C  CG  . LYS A 1 22  ? -21.062 -8.856  3.630   0.56 100.45 ? 285  LYS A CG  1 
ATOM   105  C  CD  . LYS A 1 22  ? -20.330 -7.572  3.304   0.56 101.73 ? 285  LYS A CD  1 
ATOM   106  C  CE  . LYS A 1 22  ? -20.214 -6.636  4.488   0.56 101.97 ? 285  LYS A CE  1 
ATOM   107  N  NZ  . LYS A 1 22  ? -19.587 -5.347  4.111   0.56 101.14 ? 285  LYS A NZ  1 
ATOM   108  N  N   . GLN A 1 23  ? -24.369 -9.788  2.788   0.56 95.23  ? 286  GLN A N   1 
ATOM   109  C  CA  . GLN A 1 23  ? -25.586 -9.298  3.483   0.56 98.12  ? 286  GLN A CA  1 
ATOM   110  C  C   . GLN A 1 23  ? -26.384 -10.495 4.001   0.56 98.44  ? 286  GLN A C   1 
ATOM   111  O  O   . GLN A 1 23  ? -26.965 -10.385 5.092   0.56 102.37 ? 286  GLN A O   1 
ATOM   112  C  CB  . GLN A 1 23  ? -26.416 -8.437  2.532   0.56 97.12  ? 286  GLN A CB  1 
ATOM   113  C  CG  . GLN A 1 23  ? -25.700 -7.168  2.095   0.56 99.08  ? 286  GLN A CG  1 
ATOM   114  C  CD  . GLN A 1 23  ? -26.547 -6.332  1.168   0.56 102.69 ? 286  GLN A CD  1 
ATOM   115  O  OE1 . GLN A 1 23  ? -27.640 -6.726  0.771   0.56 102.79 ? 286  GLN A OE1 1 
ATOM   116  N  NE2 . GLN A 1 23  ? -26.040 -5.162  0.816   0.56 104.29 ? 286  GLN A NE2 1 
ATOM   117  N  N   . GLU A 1 24  ? -26.399 -11.591 3.244   0.56 97.66  ? 287  GLU A N   1 
ATOM   118  C  CA  . GLU A 1 24  ? -27.179 -12.788 3.643   0.56 98.75  ? 287  GLU A CA  1 
ATOM   119  C  C   . GLU A 1 24  ? -26.473 -13.480 4.808   0.56 102.28 ? 287  GLU A C   1 
ATOM   120  O  O   . GLU A 1 24  ? -27.100 -14.345 5.443   0.56 102.77 ? 287  GLU A O   1 
ATOM   121  C  CB  . GLU A 1 24  ? -27.326 -13.724 2.446   0.56 99.32  ? 287  GLU A CB  1 
ATOM   122  C  CG  . GLU A 1 24  ? -28.082 -13.086 1.296   0.56 99.07  ? 287  GLU A CG  1 
ATOM   123  C  CD  . GLU A 1 24  ? -27.850 -13.725 -0.061  0.56 95.76  ? 287  GLU A CD  1 
ATOM   124  O  OE1 . GLU A 1 24  ? -28.715 -13.563 -0.941  0.56 92.86  ? 287  GLU A OE1 1 
ATOM   125  O  OE2 . GLU A 1 24  ? -26.800 -14.372 -0.236  0.56 88.79  ? 287  GLU A OE2 1 
ATOM   126  N  N   . HIS A 1 25  ? -25.215 -13.114 5.060   0.56 109.86 ? 288  HIS A N   1 
ATOM   127  C  CA  . HIS A 1 25  ? -24.437 -13.731 6.168   0.56 115.66 ? 288  HIS A CA  1 
ATOM   128  C  C   . HIS A 1 25  ? -23.813 -12.626 7.024   0.56 121.48 ? 288  HIS A C   1 
ATOM   129  O  O   . HIS A 1 25  ? -22.699 -12.838 7.537   0.56 120.81 ? 288  HIS A O   1 
ATOM   130  C  CB  . HIS A 1 25  ? -23.388 -14.700 5.608   0.56 112.59 ? 288  HIS A CB  1 
ATOM   131  C  CG  . HIS A 1 25  ? -23.965 -15.824 4.817   0.56 109.11 ? 288  HIS A CG  1 
ATOM   132  N  ND1 . HIS A 1 25  ? -24.630 -16.878 5.409   0.56 108.64 ? 288  HIS A ND1 1 
ATOM   133  C  CD2 . HIS A 1 25  ? -23.974 -16.068 3.489   0.56 106.55 ? 288  HIS A CD2 1 
ATOM   134  C  CE1 . HIS A 1 25  ? -25.030 -17.721 4.480   0.56 104.96 ? 288  HIS A CE1 1 
ATOM   135  N  NE2 . HIS A 1 25  ? -24.639 -17.248 3.293   0.56 103.74 ? 288  HIS A NE2 1 
ATOM   136  N  N   . GLU A 1 26  ? -24.497 -11.487 7.157   0.56 126.62 ? 289  GLU A N   1 
ATOM   137  C  CA  . GLU A 1 26  ? -23.921 -10.334 7.899   0.56 129.19 ? 289  GLU A CA  1 
ATOM   138  C  C   . GLU A 1 26  ? -23.601 -10.739 9.342   0.56 132.48 ? 289  GLU A C   1 
ATOM   139  O  O   . GLU A 1 26  ? -22.770 -10.055 9.969   0.56 135.54 ? 289  GLU A O   1 
ATOM   140  C  CB  . GLU A 1 26  ? -24.892 -9.152  7.876   0.56 129.07 ? 289  GLU A CB  1 
ATOM   141  C  CG  . GLU A 1 26  ? -24.250 -7.830  8.247   0.56 125.64 ? 289  GLU A CG  1 
ATOM   142  C  CD  . GLU A 1 26  ? -23.725 -7.035  7.066   0.56 122.83 ? 289  GLU A CD  1 
ATOM   143  O  OE1 . GLU A 1 26  ? -22.819 -6.205  7.271   0.56 122.42 ? 289  GLU A OE1 1 
ATOM   144  O  OE2 . GLU A 1 26  ? -24.233 -7.238  5.945   0.56 115.05 ? 289  GLU A OE2 1 
ATOM   145  N  N   . THR A 1 27  ? -24.216 -11.813 9.844   0.34 128.44 ? 290  THR A N   1 
ATOM   146  C  CA  . THR A 1 27  ? -24.020 -12.197 11.268  0.34 125.28 ? 290  THR A CA  1 
ATOM   147  C  C   . THR A 1 27  ? -22.868 -13.200 11.396  0.34 123.25 ? 290  THR A C   1 
ATOM   148  O  O   . THR A 1 27  ? -22.831 -13.918 12.413  0.34 121.53 ? 290  THR A O   1 
ATOM   149  C  CB  . THR A 1 27  ? -25.316 -12.753 11.867  0.34 125.43 ? 290  THR A CB  1 
ATOM   150  O  OG1 . THR A 1 27  ? -25.657 -13.940 11.150  0.34 128.05 ? 290  THR A OG1 1 
ATOM   151  C  CG2 . THR A 1 27  ? -26.462 -11.767 11.802  0.34 123.12 ? 290  THR A CG2 1 
ATOM   152  N  N   . SER A 1 28  ? -21.972 -13.247 10.404  0.34 119.56 ? 291  SER A N   1 
ATOM   153  C  CA  . SER A 1 28  ? -20.822 -14.188 10.440  0.34 115.44 ? 291  SER A CA  1 
ATOM   154  C  C   . SER A 1 28  ? -19.699 -13.694 9.525   0.34 115.06 ? 291  SER A C   1 
ATOM   155  O  O   . SER A 1 28  ? -18.702 -14.424 9.384   0.34 114.42 ? 291  SER A O   1 
ATOM   156  C  CB  . SER A 1 28  ? -21.260 -15.572 10.045  0.34 113.57 ? 291  SER A CB  1 
ATOM   157  O  OG  . SER A 1 28  ? -22.272 -16.054 10.915  0.34 112.88 ? 291  SER A OG  1 
ATOM   158  N  N   . TRP A 1 29  ? -19.840 -12.504 8.938   0.50 115.84 ? 292  TRP A N   1 
ATOM   159  C  CA  . TRP A 1 29  ? -18.832 -12.042 7.943   0.50 119.68 ? 292  TRP A CA  1 
ATOM   160  C  C   . TRP A 1 29  ? -17.500 -11.727 8.629   0.50 121.33 ? 292  TRP A C   1 
ATOM   161  O  O   . TRP A 1 29  ? -17.436 -10.714 9.344   0.50 125.47 ? 292  TRP A O   1 
ATOM   162  C  CB  . TRP A 1 29  ? -19.361 -10.839 7.156   0.50 118.91 ? 292  TRP A CB  1 
ATOM   163  C  CG  . TRP A 1 29  ? -18.688 -10.641 5.832   0.50 119.13 ? 292  TRP A CG  1 
ATOM   164  C  CD1 . TRP A 1 29  ? -17.888 -9.599  5.462   0.50 118.91 ? 292  TRP A CD1 1 
ATOM   165  C  CD2 . TRP A 1 29  ? -18.752 -11.519 4.695   0.50 115.92 ? 292  TRP A CD2 1 
ATOM   166  N  NE1 . TRP A 1 29  ? -17.456 -9.765  4.174   0.50 117.78 ? 292  TRP A NE1 1 
ATOM   167  C  CE2 . TRP A 1 29  ? -17.968 -10.934 3.678   0.50 116.89 ? 292  TRP A CE2 1 
ATOM   168  C  CE3 . TRP A 1 29  ? -19.393 -12.735 4.436   0.50 112.33 ? 292  TRP A CE3 1 
ATOM   169  C  CZ2 . TRP A 1 29  ? -17.812 -11.527 2.427   0.50 115.06 ? 292  TRP A CZ2 1 
ATOM   170  C  CZ3 . TRP A 1 29  ? -19.237 -13.320 3.200   0.50 111.99 ? 292  TRP A CZ3 1 
ATOM   171  C  CH2 . TRP A 1 29  ? -18.457 -12.722 2.210   0.50 113.37 ? 292  TRP A CH2 1 
ATOM   172  N  N   . HIS A 1 30  ? -16.478 -12.556 8.391   0.50 122.79 ? 293  HIS A N   1 
ATOM   173  C  CA  . HIS A 1 30  ? -15.137 -12.333 8.993   0.50 123.56 ? 293  HIS A CA  1 
ATOM   174  C  C   . HIS A 1 30  ? -14.065 -12.303 7.898   0.50 124.79 ? 293  HIS A C   1 
ATOM   175  O  O   . HIS A 1 30  ? -14.042 -13.237 7.082   0.50 130.14 ? 293  HIS A O   1 
ATOM   176  C  CB  . HIS A 1 30  ? -14.846 -13.405 10.050  0.50 121.96 ? 293  HIS A CB  1 
ATOM   177  C  CG  . HIS A 1 30  ? -14.881 -14.805 9.540   0.50 121.46 ? 293  HIS A CG  1 
ATOM   178  N  ND1 . HIS A 1 30  ? -16.061 -15.500 9.377   0.50 120.70 ? 293  HIS A ND1 1 
ATOM   179  C  CD2 . HIS A 1 30  ? -13.889 -15.648 9.183   0.50 122.32 ? 293  HIS A CD2 1 
ATOM   180  C  CE1 . HIS A 1 30  ? -15.797 -16.709 8.928   0.50 121.33 ? 293  HIS A CE1 1 
ATOM   181  N  NE2 . HIS A 1 30  ? -14.470 -16.825 8.800   0.50 123.29 ? 293  HIS A NE2 1 
ATOM   182  N  N   . TYR A 1 31  ? -13.218 -11.271 7.885   0.50 124.78 ? 294  TYR A N   1 
ATOM   183  C  CA  . TYR A 1 31  ? -12.107 -11.195 6.900   0.50 125.80 ? 294  TYR A CA  1 
ATOM   184  C  C   . TYR A 1 31  ? -10.910 -11.983 7.437   0.50 128.06 ? 294  TYR A C   1 
ATOM   185  O  O   . TYR A 1 31  ? -9.880  -11.362 7.752   0.50 126.68 ? 294  TYR A O   1 
ATOM   186  C  CB  . TYR A 1 31  ? -11.729 -9.738  6.633   0.50 126.34 ? 294  TYR A CB  1 
ATOM   187  C  CG  . TYR A 1 31  ? -10.815 -9.531  5.451   0.50 130.40 ? 294  TYR A CG  1 
ATOM   188  C  CD1 . TYR A 1 31  ? -9.456  -9.329  5.623   0.50 131.10 ? 294  TYR A CD1 1 
ATOM   189  C  CD2 . TYR A 1 31  ? -11.309 -9.537  4.158   0.50 131.82 ? 294  TYR A CD2 1 
ATOM   190  C  CE1 . TYR A 1 31  ? -8.612  -9.138  4.543   0.50 130.10 ? 294  TYR A CE1 1 
ATOM   191  C  CE2 . TYR A 1 31  ? -10.479 -9.347  3.066   0.50 129.46 ? 294  TYR A CE2 1 
ATOM   192  C  CZ  . TYR A 1 31  ? -9.125  -9.147  3.259   0.50 129.24 ? 294  TYR A CZ  1 
ATOM   193  O  OH  . TYR A 1 31  ? -8.300  -8.958  2.188   0.50 127.50 ? 294  TYR A OH  1 
ATOM   194  N  N   . ASP A 1 32  ? -11.037 -13.309 7.522   0.50 131.07 ? 295  ASP A N   1 
ATOM   195  C  CA  . ASP A 1 32  ? -9.953  -14.145 8.106   0.50 134.01 ? 295  ASP A CA  1 
ATOM   196  C  C   . ASP A 1 32  ? -8.610  -13.701 7.522   0.50 139.23 ? 295  ASP A C   1 
ATOM   197  O  O   . ASP A 1 32  ? -8.526  -13.534 6.292   0.50 142.42 ? 295  ASP A O   1 
ATOM   198  C  CB  . ASP A 1 32  ? -10.217 -15.638 7.888   0.50 130.98 ? 295  ASP A CB  1 
ATOM   199  C  CG  . ASP A 1 32  ? -9.171  -16.543 8.515   0.50 128.61 ? 295  ASP A CG  1 
ATOM   200  O  OD1 . ASP A 1 32  ? -8.218  -16.011 9.116   0.50 129.34 ? 295  ASP A OD1 1 
ATOM   201  O  OD2 . ASP A 1 32  ? -9.322  -17.773 8.398   0.50 124.60 ? 295  ASP A OD2 1 
ATOM   202  N  N   . GLN A 1 33  ? -7.609  -13.506 8.383   0.50 143.48 ? 296  GLN A N   1 
ATOM   203  C  CA  . GLN A 1 33  ? -6.279  -13.035 7.918   0.50 145.07 ? 296  GLN A CA  1 
ATOM   204  C  C   . GLN A 1 33  ? -5.360  -14.245 7.740   0.50 143.87 ? 296  GLN A C   1 
ATOM   205  O  O   . GLN A 1 33  ? -4.249  -14.065 7.211   0.50 144.34 ? 296  GLN A O   1 
ATOM   206  C  CB  . GLN A 1 33  ? -5.688  -12.036 8.915   0.50 145.26 ? 296  GLN A CB  1 
ATOM   207  C  CG  . GLN A 1 33  ? -6.665  -10.953 9.351   0.50 145.15 ? 296  GLN A CG  1 
ATOM   208  C  CD  . GLN A 1 33  ? -7.106  -10.061 8.217   0.50 144.08 ? 296  GLN A CD  1 
ATOM   209  O  OE1 . GLN A 1 33  ? -6.651  -10.190 7.082   0.50 141.02 ? 296  GLN A OE1 1 
ATOM   210  N  NE2 . GLN A 1 33  ? -8.003  -9.138  8.520   0.50 144.01 ? 296  GLN A NE2 1 
ATOM   211  N  N   . ASP A 1 34  ? -5.819  -15.426 8.160   0.50 142.02 ? 297  ASP A N   1 
ATOM   212  C  CA  . ASP A 1 34  ? -5.008  -16.662 8.012   0.50 139.85 ? 297  ASP A CA  1 
ATOM   213  C  C   . ASP A 1 34  ? -5.516  -17.466 6.811   0.50 135.11 ? 297  ASP A C   1 
ATOM   214  O  O   . ASP A 1 34  ? -5.261  -18.684 6.774   0.50 137.69 ? 297  ASP A O   1 
ATOM   215  C  CB  . ASP A 1 34  ? -5.030  -17.506 9.288   0.50 141.67 ? 297  ASP A CB  1 
ATOM   216  C  CG  . ASP A 1 34  ? -4.405  -16.817 10.488  0.50 143.63 ? 297  ASP A CG  1 
ATOM   217  O  OD1 . ASP A 1 34  ? -3.980  -15.654 10.342  0.50 146.85 ? 297  ASP A OD1 1 
ATOM   218  O  OD2 . ASP A 1 34  ? -4.347  -17.451 11.558  0.50 140.67 ? 297  ASP A OD2 1 
ATOM   219  N  N   . HIS A 1 35  ? -6.214  -16.810 5.878   0.34 124.74 ? 298  HIS A N   1 
ATOM   220  C  CA  . HIS A 1 35  ? -6.771  -17.516 4.692   0.34 113.56 ? 298  HIS A CA  1 
ATOM   221  C  C   . HIS A 1 35  ? -5.620  -18.089 3.862   0.34 106.78 ? 298  HIS A C   1 
ATOM   222  O  O   . HIS A 1 35  ? -4.584  -17.409 3.742   0.34 105.85 ? 298  HIS A O   1 
ATOM   223  C  CB  . HIS A 1 35  ? -7.686  -16.587 3.883   0.34 111.43 ? 298  HIS A CB  1 
ATOM   224  C  CG  . HIS A 1 35  ? -6.966  -15.543 3.100   0.34 107.44 ? 298  HIS A CG  1 
ATOM   225  N  ND1 . HIS A 1 35  ? -6.823  -14.248 3.555   0.34 105.81 ? 298  HIS A ND1 1 
ATOM   226  C  CD2 . HIS A 1 35  ? -6.359  -15.592 1.895   0.34 103.95 ? 298  HIS A CD2 1 
ATOM   227  C  CE1 . HIS A 1 35  ? -6.156  -13.543 2.665   0.34 103.83 ? 298  HIS A CE1 1 
ATOM   228  N  NE2 . HIS A 1 35  ? -5.858  -14.346 1.637   0.34 103.48 ? 298  HIS A NE2 1 
ATOM   229  N  N   . PRO A 1 36  ? -5.755  -19.301 3.283   0.34 97.43  ? 299  PRO A N   1 
ATOM   230  C  CA  . PRO A 1 36  ? -4.658  -19.938 2.555   0.34 93.00  ? 299  PRO A CA  1 
ATOM   231  C  C   . PRO A 1 36  ? -4.661  -19.671 1.046   0.34 91.46  ? 299  PRO A C   1 
ATOM   232  O  O   . PRO A 1 36  ? -4.285  -20.562 0.311   0.34 91.77  ? 299  PRO A O   1 
ATOM   233  C  CB  . PRO A 1 36  ? -5.024  -21.410 2.746   0.34 93.71  ? 299  PRO A CB  1 
ATOM   234  C  CG  . PRO A 1 36  ? -6.532  -21.416 2.643   0.34 94.89  ? 299  PRO A CG  1 
ATOM   235  C  CD  . PRO A 1 36  ? -6.964  -20.127 3.310   0.34 96.02  ? 299  PRO A CD  1 
ATOM   236  N  N   . TYR A 1 37  ? -5.065  -18.473 0.621   0.34 87.08  ? 300  TYR A N   1 
ATOM   237  C  CA  . TYR A 1 37  ? -5.196  -18.221 -0.838  0.34 84.14  ? 300  TYR A CA  1 
ATOM   238  C  C   . TYR A 1 37  ? -4.066  -17.314 -1.330  0.34 84.77  ? 300  TYR A C   1 
ATOM   239  O  O   . TYR A 1 37  ? -3.776  -16.300 -0.669  0.34 85.73  ? 300  TYR A O   1 
ATOM   240  C  CB  . TYR A 1 37  ? -6.582  -17.648 -1.149  0.34 81.55  ? 300  TYR A CB  1 
ATOM   241  C  CG  . TYR A 1 37  ? -7.721  -18.499 -0.650  0.34 76.34  ? 300  TYR A CG  1 
ATOM   242  C  CD1 . TYR A 1 37  ? -8.192  -19.566 -1.396  0.34 73.43  ? 300  TYR A CD1 1 
ATOM   243  C  CD2 . TYR A 1 37  ? -8.318  -18.251 0.574   0.34 75.47  ? 300  TYR A CD2 1 
ATOM   244  C  CE1 . TYR A 1 37  ? -9.231  -20.360 -0.944  0.34 71.71  ? 300  TYR A CE1 1 
ATOM   245  C  CE2 . TYR A 1 37  ? -9.360  -19.035 1.041   0.34 73.58  ? 300  TYR A CE2 1 
ATOM   246  C  CZ  . TYR A 1 37  ? -9.818  -20.094 0.279   0.34 70.27  ? 300  TYR A CZ  1 
ATOM   247  O  OH  . TYR A 1 37  ? -10.842 -20.875 0.728   0.34 70.38  ? 300  TYR A OH  1 
ATOM   248  N  N   . LYS A 1 38  ? -3.450  -17.681 -2.456  0.44 85.22  ? 301  LYS A N   1 
ATOM   249  C  CA  . LYS A 1 38  ? -2.378  -16.843 -3.051  0.44 87.02  ? 301  LYS A CA  1 
ATOM   250  C  C   . LYS A 1 38  ? -2.789  -16.428 -4.467  0.44 84.80  ? 301  LYS A C   1 
ATOM   251  O  O   . LYS A 1 38  ? -2.681  -15.231 -4.778  0.44 85.35  ? 301  LYS A O   1 
ATOM   252  C  CB  . LYS A 1 38  ? -1.059  -17.617 -3.091  0.44 88.05  ? 301  LYS A CB  1 
ATOM   253  C  CG  . LYS A 1 38  ? 0.152   -16.809 -3.536  0.44 90.08  ? 301  LYS A CG  1 
ATOM   254  C  CD  . LYS A 1 38  ? 0.477   -15.663 -2.602  0.44 92.57  ? 301  LYS A CD  1 
ATOM   255  C  CE  . LYS A 1 38  ? 1.720   -14.902 -3.011  0.44 94.41  ? 301  LYS A CE  1 
ATOM   256  N  NZ  . LYS A 1 38  ? 2.049   -13.827 -2.046  0.44 94.23  ? 301  LYS A NZ  1 
ATOM   257  N  N   . THR A 1 39  ? -3.243  -17.382 -5.285  0.44 82.30  ? 302  THR A N   1 
ATOM   258  C  CA  . THR A 1 39  ? -3.594  -17.076 -6.699  0.44 80.30  ? 302  THR A CA  1 
ATOM   259  C  C   . THR A 1 39  ? -5.078  -16.706 -6.800  0.44 74.51  ? 302  THR A C   1 
ATOM   260  O  O   . THR A 1 39  ? -5.456  -16.086 -7.808  0.44 72.24  ? 302  THR A O   1 
ATOM   261  C  CB  . THR A 1 39  ? -3.219  -18.247 -7.615  0.44 79.63  ? 302  THR A CB  1 
ATOM   262  O  OG1 . THR A 1 39  ? -4.090  -19.340 -7.322  0.44 79.73  ? 302  THR A OG1 1 
ATOM   263  C  CG2 . THR A 1 39  ? -1.779  -18.678 -7.451  0.44 79.40  ? 302  THR A CG2 1 
ATOM   264  N  N   . TRP A 1 40  ? -5.875  -17.072 -5.793  0.44 69.43  ? 303  TRP A N   1 
ATOM   265  C  CA  . TRP A 1 40  ? -7.329  -16.762 -5.789  0.44 64.41  ? 303  TRP A CA  1 
ATOM   266  C  C   . TRP A 1 40  ? -7.589  -15.545 -4.899  0.44 64.73  ? 303  TRP A C   1 
ATOM   267  O  O   . TRP A 1 40  ? -7.137  -15.561 -3.742  0.44 64.18  ? 303  TRP A O   1 
ATOM   268  C  CB  . TRP A 1 40  ? -8.123  -17.981 -5.310  0.44 63.14  ? 303  TRP A CB  1 
ATOM   269  C  CG  . TRP A 1 40  ? -8.248  -19.065 -6.334  0.44 60.07  ? 303  TRP A CG  1 
ATOM   270  C  CD1 . TRP A 1 40  ? -7.297  -19.973 -6.697  0.44 59.36  ? 303  TRP A CD1 1 
ATOM   271  C  CD2 . TRP A 1 40  ? -9.408  -19.358 -7.131  0.44 59.67  ? 303  TRP A CD2 1 
ATOM   272  N  NE1 . TRP A 1 40  ? -7.783  -20.807 -7.667  0.44 58.85  ? 303  TRP A NE1 1 
ATOM   273  C  CE2 . TRP A 1 40  ? -9.075  -20.455 -7.953  0.44 58.95  ? 303  TRP A CE2 1 
ATOM   274  C  CE3 . TRP A 1 40  ? -10.688 -18.802 -7.230  0.44 58.96  ? 303  TRP A CE3 1 
ATOM   275  C  CZ2 . TRP A 1 40  ? -9.980  -21.002 -8.861  0.44 57.11  ? 303  TRP A CZ2 1 
ATOM   276  C  CZ3 . TRP A 1 40  ? -11.580 -19.344 -8.127  0.44 57.52  ? 303  TRP A CZ3 1 
ATOM   277  C  CH2 . TRP A 1 40  ? -11.228 -20.428 -8.930  0.44 56.13  ? 303  TRP A CH2 1 
ATOM   278  N  N   . ALA A 1 41  ? -8.299  -14.541 -5.418  0.50 61.36  ? 304  ALA A N   1 
ATOM   279  C  CA  . ALA A 1 41  ? -8.623  -13.333 -4.624  0.50 61.57  ? 304  ALA A CA  1 
ATOM   280  C  C   . ALA A 1 41  ? -9.583  -13.699 -3.491  0.50 61.17  ? 304  ALA A C   1 
ATOM   281  O  O   . ALA A 1 41  ? -10.642 -14.270 -3.783  0.50 55.82  ? 304  ALA A O   1 
ATOM   282  C  CB  . ALA A 1 41  ? -9.208  -12.263 -5.509  0.50 59.70  ? 304  ALA A CB  1 
ATOM   283  N  N   . TYR A 1 42  ? -9.211  -13.380 -2.250  0.34 63.85  ? 305  TYR A N   1 
ATOM   284  C  CA  . TYR A 1 42  ? -10.092 -13.646 -1.084  0.34 64.09  ? 305  TYR A CA  1 
ATOM   285  C  C   . TYR A 1 42  ? -10.887 -12.373 -0.796  0.34 65.97  ? 305  TYR A C   1 
ATOM   286  O  O   . TYR A 1 42  ? -10.269 -11.299 -0.674  0.34 67.88  ? 305  TYR A O   1 
ATOM   287  C  CB  . TYR A 1 42  ? -9.254  -14.094 0.115   0.34 63.16  ? 305  TYR A CB  1 
ATOM   288  C  CG  . TYR A 1 42  ? -9.974  -14.130 1.438   0.34 62.41  ? 305  TYR A CG  1 
ATOM   289  C  CD1 . TYR A 1 42  ? -10.684 -15.250 1.834   0.34 61.99  ? 305  TYR A CD1 1 
ATOM   290  C  CD2 . TYR A 1 42  ? -9.927  -13.051 2.305   0.34 63.22  ? 305  TYR A CD2 1 
ATOM   291  C  CE1 . TYR A 1 42  ? -11.338 -15.293 3.053   0.34 61.78  ? 305  TYR A CE1 1 
ATOM   292  C  CE2 . TYR A 1 42  ? -10.576 -13.078 3.527   0.34 61.85  ? 305  TYR A CE2 1 
ATOM   293  C  CZ  . TYR A 1 42  ? -11.285 -14.204 3.903   0.34 62.59  ? 305  TYR A CZ  1 
ATOM   294  O  OH  . TYR A 1 42  ? -11.928 -14.237 5.106   0.34 63.50  ? 305  TYR A OH  1 
ATOM   295  N  N   . HIS A 1 43  ? -12.212 -12.486 -0.714  0.34 68.26  ? 306  HIS A N   1 
ATOM   296  C  CA  . HIS A 1 43  ? -13.062 -11.282 -0.521  0.34 66.43  ? 306  HIS A CA  1 
ATOM   297  C  C   . HIS A 1 43  ? -13.642 -11.280 0.896   0.34 68.01  ? 306  HIS A C   1 
ATOM   298  O  O   . HIS A 1 43  ? -13.974 -10.189 1.394   0.34 68.23  ? 306  HIS A O   1 
ATOM   299  C  CB  . HIS A 1 43  ? -14.143 -11.228 -1.607  0.34 63.76  ? 306  HIS A CB  1 
ATOM   300  C  CG  . HIS A 1 43  ? -13.594 -11.161 -2.991  0.34 60.84  ? 306  HIS A CG  1 
ATOM   301  N  ND1 . HIS A 1 43  ? -13.366 -9.963  -3.636  0.34 59.86  ? 306  HIS A ND1 1 
ATOM   302  C  CD2 . HIS A 1 43  ? -13.223 -12.132 -3.851  0.34 60.28  ? 306  HIS A CD2 1 
ATOM   303  C  CE1 . HIS A 1 43  ? -12.879 -10.198 -4.836  0.34 59.60  ? 306  HIS A CE1 1 
ATOM   304  N  NE2 . HIS A 1 43  ? -12.781 -11.521 -4.992  0.34 58.65  ? 306  HIS A NE2 1 
ATOM   305  N  N   . GLY A 1 44  ? -13.753 -12.458 1.514   0.50 67.56  ? 307  GLY A N   1 
ATOM   306  C  CA  . GLY A 1 44  ? -14.291 -12.548 2.882   0.50 69.36  ? 307  GLY A CA  1 
ATOM   307  C  C   . GLY A 1 44  ? -14.686 -13.963 3.250   0.50 70.83  ? 307  GLY A C   1 
ATOM   308  O  O   . GLY A 1 44  ? -14.501 -14.861 2.413   0.50 71.71  ? 307  GLY A O   1 
ATOM   309  N  N   . SER A 1 45  ? -15.228 -14.151 4.454   0.50 76.45  ? 308  SER A N   1 
ATOM   310  C  CA  . SER A 1 45  ? -15.591 -15.512 4.927   0.50 81.32  ? 308  SER A CA  1 
ATOM   311  C  C   . SER A 1 45  ? -16.833 -15.465 5.822   0.50 83.20  ? 308  SER A C   1 
ATOM   312  O  O   . SER A 1 45  ? -17.179 -14.366 6.282   0.50 81.70  ? 308  SER A O   1 
ATOM   313  C  CB  . SER A 1 45  ? -14.434 -16.153 5.645   0.50 84.01  ? 308  SER A CB  1 
ATOM   314  O  OG  . SER A 1 45  ? -13.343 -16.362 4.764   0.50 80.86  ? 308  SER A OG  1 
ATOM   315  N  N   . TYR A 1 46  ? -17.468 -16.618 6.049   0.50 89.95  ? 309  TYR A N   1 
ATOM   316  C  CA  . TYR A 1 46  ? -18.686 -16.718 6.905   0.50 94.24  ? 309  TYR A CA  1 
ATOM   317  C  C   . TYR A 1 46  ? -18.843 -18.155 7.430   0.50 96.38  ? 309  TYR A C   1 
ATOM   318  O  O   . TYR A 1 46  ? -18.203 -19.073 6.880   0.50 99.77  ? 309  TYR A O   1 
ATOM   319  C  CB  . TYR A 1 46  ? -19.927 -16.236 6.143   0.50 94.77  ? 309  TYR A CB  1 
ATOM   320  C  CG  . TYR A 1 46  ? -20.452 -17.159 5.068   0.50 96.37  ? 309  TYR A CG  1 
ATOM   321  C  CD1 . TYR A 1 46  ? -21.201 -18.279 5.389   0.50 97.33  ? 309  TYR A CD1 1 
ATOM   322  C  CD2 . TYR A 1 46  ? -20.238 -16.894 3.723   0.50 97.96  ? 309  TYR A CD2 1 
ATOM   323  C  CE1 . TYR A 1 46  ? -21.698 -19.126 4.410   0.50 98.39  ? 309  TYR A CE1 1 
ATOM   324  C  CE2 . TYR A 1 46  ? -20.729 -17.730 2.731   0.50 98.89  ? 309  TYR A CE2 1 
ATOM   325  C  CZ  . TYR A 1 46  ? -21.465 -18.851 3.075   0.50 100.33 ? 309  TYR A CZ  1 
ATOM   326  O  OH  . TYR A 1 46  ? -21.957 -19.684 2.110   0.50 99.74  ? 309  TYR A OH  1 
ATOM   327  N  N   . GLU A 1 47  ? -19.672 -18.338 8.466   0.44 97.84  ? 310  GLU A N   1 
ATOM   328  C  CA  . GLU A 1 47  ? -19.837 -19.613 9.221   0.44 102.31 ? 310  GLU A CA  1 
ATOM   329  C  C   . GLU A 1 47  ? -20.691 -20.600 8.416   0.44 103.82 ? 310  GLU A C   1 
ATOM   330  O  O   . GLU A 1 47  ? -21.676 -20.153 7.799   0.44 107.33 ? 310  GLU A O   1 
ATOM   331  C  CB  . GLU A 1 47  ? -20.479 -19.333 10.582  0.44 104.70 ? 310  GLU A CB  1 
ATOM   332  C  CG  . GLU A 1 47  ? -20.780 -20.586 11.390  0.44 106.06 ? 310  GLU A CG  1 
ATOM   333  C  CD  . GLU A 1 47  ? -21.377 -20.321 12.763  0.44 104.98 ? 310  GLU A CD  1 
ATOM   334  O  OE1 . GLU A 1 47  ? -21.542 -19.136 13.116  0.44 101.00 ? 310  GLU A OE1 1 
ATOM   335  O  OE2 . GLU A 1 47  ? -21.674 -21.300 13.478  0.44 106.14 ? 310  GLU A OE2 1 
ATOM   336  N  N   . THR A 1 48  ? -20.335 -21.892 8.447   0.44 109.43 ? 311  THR A N   1 
ATOM   337  C  CA  . THR A 1 48  ? -21.045 -22.997 7.741   0.44 113.95 ? 311  THR A CA  1 
ATOM   338  C  C   . THR A 1 48  ? -20.849 -24.324 8.486   0.44 115.24 ? 311  THR A C   1 
ATOM   339  O  O   . THR A 1 48  ? -20.193 -24.316 9.547   0.44 115.92 ? 311  THR A O   1 
ATOM   340  C  CB  . THR A 1 48  ? -20.568 -23.125 6.289   0.44 117.32 ? 311  THR A CB  1 
ATOM   341  O  OG1 . THR A 1 48  ? -19.157 -22.906 6.263   0.44 120.66 ? 311  THR A OG1 1 
ATOM   342  C  CG2 . THR A 1 48  ? -21.253 -22.149 5.359   0.44 117.18 ? 311  THR A CG2 1 
ATOM   343  N  N   . LYS A 1 49  ? -21.407 -25.413 7.940   0.44 117.39 ? 312  LYS A N   1 
ATOM   344  C  CA  . LYS A 1 49  ? -21.273 -26.803 8.458   0.44 119.40 ? 312  LYS A CA  1 
ATOM   345  C  C   . LYS A 1 49  ? -21.626 -27.798 7.346   0.44 121.69 ? 312  LYS A C   1 
ATOM   346  O  O   . LYS A 1 49  ? -21.532 -29.013 7.617   0.44 123.78 ? 312  LYS A O   1 
ATOM   347  C  CB  . LYS A 1 49  ? -22.173 -27.018 9.679   0.44 117.76 ? 312  LYS A CB  1 
ATOM   348  C  CG  . LYS A 1 49  ? -21.562 -26.609 11.012  0.44 119.24 ? 312  LYS A CG  1 
ATOM   349  C  CD  . LYS A 1 49  ? -22.392 -27.023 12.207  0.44 119.18 ? 312  LYS A CD  1 
ATOM   350  C  CE  . LYS A 1 49  ? -21.759 -26.645 13.529  0.44 119.32 ? 312  LYS A CE  1 
ATOM   351  N  NZ  . LYS A 1 49  ? -22.621 -27.025 14.673  0.44 120.74 ? 312  LYS A NZ  1 
ATOM   352  N  N   . SER A 1 56  ? -18.224 -43.654 -1.136  0.44 65.86  ? 319  SER A N   1 
ATOM   353  C  CA  . SER A 1 56  ? -18.098 -44.820 -2.052  0.44 66.19  ? 319  SER A CA  1 
ATOM   354  C  C   . SER A 1 56  ? -18.658 -46.078 -1.373  0.44 61.28  ? 319  SER A C   1 
ATOM   355  O  O   . SER A 1 56  ? -17.999 -46.600 -0.452  0.44 57.44  ? 319  SER A O   1 
ATOM   356  C  CB  . SER A 1 56  ? -16.668 -45.026 -2.495  0.44 69.27  ? 319  SER A CB  1 
ATOM   357  O  OG  . SER A 1 56  ? -15.798 -45.146 -1.380  0.44 72.62  ? 319  SER A OG  1 
ATOM   358  N  N   . MET A 1 57  ? -19.822 -46.547 -1.838  0.44 55.88  ? 320  MET A N   1 
ATOM   359  C  CA  . MET A 1 57  ? -20.565 -47.718 -1.295  0.44 50.85  ? 320  MET A CA  1 
ATOM   360  C  C   . MET A 1 57  ? -20.353 -48.919 -2.225  0.44 42.88  ? 320  MET A C   1 
ATOM   361  O  O   . MET A 1 57  ? -20.224 -48.701 -3.440  0.44 42.23  ? 320  MET A O   1 
ATOM   362  C  CB  . MET A 1 57  ? -22.059 -47.393 -1.205  0.44 54.56  ? 320  MET A CB  1 
ATOM   363  C  CG  . MET A 1 57  ? -22.335 -45.961 -0.758  0.44 58.23  ? 320  MET A CG  1 
ATOM   364  S  SD  . MET A 1 57  ? -21.478 -45.543 0.783   0.44 61.34  ? 320  MET A SD  1 
ATOM   365  C  CE  . MET A 1 57  ? -22.470 -46.462 1.961   0.44 59.51  ? 320  MET A CE  1 
ATOM   366  N  N   . VAL A 1 58  ? -20.311 -50.137 -1.682  0.44 37.20  ? 321  VAL A N   1 
ATOM   367  C  CA  . VAL A 1 58  ? -20.102 -51.375 -2.488  0.44 36.41  ? 321  VAL A CA  1 
ATOM   368  C  C   . VAL A 1 58  ? -21.453 -51.916 -2.968  0.44 35.75  ? 321  VAL A C   1 
ATOM   369  O  O   . VAL A 1 58  ? -22.381 -52.005 -2.145  0.44 36.83  ? 321  VAL A O   1 
ATOM   370  C  CB  . VAL A 1 58  ? -19.327 -52.452 -1.713  0.44 36.71  ? 321  VAL A CB  1 
ATOM   371  C  CG1 . VAL A 1 58  ? -19.184 -53.725 -2.533  0.44 36.38  ? 321  VAL A CG1 1 
ATOM   372  C  CG2 . VAL A 1 58  ? -17.968 -51.941 -1.266  0.44 40.22  ? 321  VAL A CG2 1 
ATOM   373  N  N   . ASN A 1 59  ? -21.522 -52.285 -4.251  0.44 31.69  ? 322  ASN A N   1 
ATOM   374  C  CA  . ASN A 1 59  ? -22.638 -53.032 -4.875  0.44 31.99  ? 322  ASN A CA  1 
ATOM   375  C  C   . ASN A 1 59  ? -22.496 -54.516 -4.522  0.44 32.97  ? 322  ASN A C   1 
ATOM   376  O  O   . ASN A 1 59  ? -21.618 -55.188 -5.108  0.44 32.79  ? 322  ASN A O   1 
ATOM   377  C  CB  . ASN A 1 59  ? -22.674 -52.813 -6.389  0.44 31.69  ? 322  ASN A CB  1 
ATOM   378  C  CG  . ASN A 1 59  ? -23.871 -53.475 -7.035  0.44 31.78  ? 322  ASN A CG  1 
ATOM   379  O  OD1 . ASN A 1 59  ? -24.281 -54.558 -6.628  0.44 31.29  ? 322  ASN A OD1 1 
ATOM   380  N  ND2 . ASN A 1 59  ? -24.444 -52.829 -8.035  0.44 33.00  ? 322  ASN A ND2 1 
ATOM   381  N  N   . GLY A 1 60  ? -23.348 -55.011 -3.621  0.44 32.42  ? 323  GLY A N   1 
ATOM   382  C  CA  . GLY A 1 60  ? -23.344 -56.404 -3.139  0.44 30.92  ? 323  GLY A CA  1 
ATOM   383  C  C   . GLY A 1 60  ? -23.622 -57.406 -4.245  0.44 32.26  ? 323  GLY A C   1 
ATOM   384  O  O   . GLY A 1 60  ? -23.021 -58.501 -4.224  0.44 33.61  ? 323  GLY A O   1 
ATOM   385  N  N   . VAL A 1 61  ? -24.508 -57.069 -5.182  0.44 31.85  ? 324  VAL A N   1 
ATOM   386  C  CA  . VAL A 1 61  ? -24.903 -58.004 -6.274  0.44 31.87  ? 324  VAL A CA  1 
ATOM   387  C  C   . VAL A 1 61  ? -23.655 -58.307 -7.113  0.44 30.02  ? 324  VAL A C   1 
ATOM   388  O  O   . VAL A 1 61  ? -23.369 -59.497 -7.320  0.44 29.19  ? 324  VAL A O   1 
ATOM   389  C  CB  . VAL A 1 61  ? -26.075 -57.451 -7.106  0.44 31.52  ? 324  VAL A CB  1 
ATOM   390  C  CG1 . VAL A 1 61  ? -26.307 -58.253 -8.372  0.44 31.68  ? 324  VAL A CG1 1 
ATOM   391  C  CG2 . VAL A 1 61  ? -27.350 -57.384 -6.278  0.44 32.57  ? 324  VAL A CG2 1 
ATOM   392  N  N   . VAL A 1 62  ? -22.922 -57.277 -7.548  0.44 30.32  ? 325  VAL A N   1 
ATOM   393  C  CA  . VAL A 1 62  ? -21.683 -57.451 -8.368  0.44 30.48  ? 325  VAL A CA  1 
ATOM   394  C  C   . VAL A 1 62  ? -20.602 -58.143 -7.520  0.44 28.94  ? 325  VAL A C   1 
ATOM   395  O  O   . VAL A 1 62  ? -19.992 -59.105 -8.019  0.44 28.76  ? 325  VAL A O   1 
ATOM   396  C  CB  . VAL A 1 62  ? -21.169 -56.122 -8.953  0.44 30.24  ? 325  VAL A CB  1 
ATOM   397  C  CG1 . VAL A 1 62  ? -19.871 -56.326 -9.720  0.44 29.31  ? 325  VAL A CG1 1 
ATOM   398  C  CG2 . VAL A 1 62  ? -22.212 -55.461 -9.841  0.44 30.43  ? 325  VAL A CG2 1 
ATOM   399  N  N   . ARG A 1 63  ? -20.384 -57.713 -6.277  0.44 28.12  ? 326  ARG A N   1 
ATOM   400  C  CA  . ARG A 1 63  ? -19.309 -58.295 -5.430  0.44 28.44  ? 326  ARG A CA  1 
ATOM   401  C  C   . ARG A 1 63  ? -19.571 -59.786 -5.169  0.44 28.35  ? 326  ARG A C   1 
ATOM   402  O  O   . ARG A 1 63  ? -18.604 -60.562 -5.276  0.44 27.80  ? 326  ARG A O   1 
ATOM   403  C  CB  . ARG A 1 63  ? -19.115 -57.547 -4.111  0.44 28.20  ? 326  ARG A CB  1 
ATOM   404  C  CG  . ARG A 1 63  ? -18.054 -58.204 -3.236  0.44 28.50  ? 326  ARG A CG  1 
ATOM   405  C  CD  . ARG A 1 63  ? -17.339 -57.271 -2.288  0.44 27.92  ? 326  ARG A CD  1 
ATOM   406  N  NE  . ARG A 1 63  ? -18.241 -56.738 -1.288  0.44 29.13  ? 326  ARG A NE  1 
ATOM   407  C  CZ  . ARG A 1 63  ? -17.871 -55.986 -0.258  0.44 30.17  ? 326  ARG A CZ  1 
ATOM   408  N  NH1 . ARG A 1 63  ? -16.590 -55.700 -0.071  0.44 29.92  ? 326  ARG A NH1 1 
ATOM   409  N  NH2 . ARG A 1 63  ? -18.788 -55.526 0.582   0.44 28.71  ? 326  ARG A NH2 1 
ATOM   410  N  N   . LEU A 1 64  ? -20.801 -60.197 -4.839  0.44 27.88  ? 327  LEU A N   1 
ATOM   411  C  CA  . LEU A 1 64  ? -21.100 -61.629 -4.544  0.44 27.75  ? 327  LEU A CA  1 
ATOM   412  C  C   . LEU A 1 64  ? -20.871 -62.483 -5.797  0.44 27.45  ? 327  LEU A C   1 
ATOM   413  O  O   . LEU A 1 64  ? -20.584 -63.678 -5.638  0.44 28.86  ? 327  LEU A O   1 
ATOM   414  C  CB  . LEU A 1 64  ? -22.535 -61.796 -4.022  0.44 29.67  ? 327  LEU A CB  1 
ATOM   415  C  CG  . LEU A 1 64  ? -22.742 -61.544 -2.527  0.44 29.34  ? 327  LEU A CG  1 
ATOM   416  C  CD1 . LEU A 1 64  ? -24.208 -61.726 -2.159  0.44 31.77  ? 327  LEU A CD1 1 
ATOM   417  C  CD2 . LEU A 1 64  ? -21.887 -62.459 -1.667  0.44 29.23  ? 327  LEU A CD2 1 
ATOM   418  N  N   . LEU A 1 65  ? -20.949 -61.904 -6.997  0.44 27.84  ? 328  LEU A N   1 
ATOM   419  C  CA  . LEU A 1 65  ? -20.788 -62.664 -8.271  0.44 27.74  ? 328  LEU A CA  1 
ATOM   420  C  C   . LEU A 1 65  ? -19.382 -62.469 -8.858  0.44 27.92  ? 328  LEU A C   1 
ATOM   421  O  O   . LEU A 1 65  ? -19.147 -62.972 -9.970  0.44 26.95  ? 328  LEU A O   1 
ATOM   422  C  CB  . LEU A 1 65  ? -21.882 -62.231 -9.252  0.44 27.79  ? 328  LEU A CB  1 
ATOM   423  C  CG  . LEU A 1 65  ? -23.307 -62.586 -8.820  0.44 28.94  ? 328  LEU A CG  1 
ATOM   424  C  CD1 . LEU A 1 65  ? -24.341 -61.964 -9.742  0.44 29.77  ? 328  LEU A CD1 1 
ATOM   425  C  CD2 . LEU A 1 65  ? -23.499 -64.088 -8.776  0.44 30.25  ? 328  LEU A CD2 1 
ATOM   426  N  N   . THR A 1 66  ? -18.482 -61.811 -8.120  0.44 27.59  ? 329  THR A N   1 
ATOM   427  C  CA  . THR A 1 66  ? -17.058 -61.617 -8.496  0.44 28.45  ? 329  THR A CA  1 
ATOM   428  C  C   . THR A 1 66  ? -16.171 -61.973 -7.290  0.44 29.45  ? 329  THR A C   1 
ATOM   429  O  O   . THR A 1 66  ? -15.308 -61.157 -6.912  0.44 32.66  ? 329  THR A O   1 
ATOM   430  C  CB  . THR A 1 66  ? -16.823 -60.196 -9.040  0.44 28.37  ? 329  THR A CB  1 
ATOM   431  O  OG1 . THR A 1 66  ? -17.214 -59.232 -8.060  0.44 26.35  ? 329  THR A OG1 1 
ATOM   432  C  CG2 . THR A 1 66  ? -17.567 -59.925 -10.329 0.44 27.97  ? 329  THR A CG2 1 
ATOM   433  N  N   . LYS A 1 67  ? -16.330 -63.177 -6.741  0.44 29.18  ? 330  LYS A N   1 
ATOM   434  C  CA  . LYS A 1 67  ? -15.640 -63.613 -5.499  0.44 30.09  ? 330  LYS A CA  1 
ATOM   435  C  C   . LYS A 1 67  ? -14.116 -63.672 -5.683  0.44 28.84  ? 330  LYS A C   1 
ATOM   436  O  O   . LYS A 1 67  ? -13.394 -63.257 -4.787  0.44 28.85  ? 330  LYS A O   1 
ATOM   437  C  CB  . LYS A 1 67  ? -16.164 -64.967 -5.016  0.44 31.62  ? 330  LYS A CB  1 
ATOM   438  C  CG  . LYS A 1 67  ? -15.767 -65.322 -3.591  0.44 32.43  ? 330  LYS A CG  1 
ATOM   439  C  CD  . LYS A 1 67  ? -16.131 -66.722 -3.187  0.44 34.28  ? 330  LYS A CD  1 
ATOM   440  C  CE  . LYS A 1 67  ? -15.958 -66.938 -1.698  0.44 38.52  ? 330  LYS A CE  1 
ATOM   441  N  NZ  . LYS A 1 67  ? -16.151 -68.358 -1.325  0.44 40.27  ? 330  LYS A NZ  1 
ATOM   442  N  N   . PRO A 1 68  ? -13.544 -64.209 -6.784  0.44 27.63  ? 331  PRO A N   1 
ATOM   443  C  CA  . PRO A 1 68  ? -12.084 -64.280 -6.909  0.44 28.81  ? 331  PRO A CA  1 
ATOM   444  C  C   . PRO A 1 68  ? -11.394 -62.924 -6.688  0.44 29.25  ? 331  PRO A C   1 
ATOM   445  O  O   . PRO A 1 68  ? -10.286 -62.900 -6.181  0.44 25.99  ? 331  PRO A O   1 
ATOM   446  C  CB  . PRO A 1 68  ? -11.857 -64.792 -8.338  0.44 28.72  ? 331  PRO A CB  1 
ATOM   447  C  CG  . PRO A 1 68  ? -13.114 -65.587 -8.622  0.44 29.95  ? 331  PRO A CG  1 
ATOM   448  C  CD  . PRO A 1 68  ? -14.229 -64.808 -7.941  0.44 29.24  ? 331  PRO A CD  1 
ATOM   449  N  N   . TRP A 1 69  ? -12.089 -61.824 -6.996  0.44 29.61  ? 332  TRP A N   1 
ATOM   450  C  CA  . TRP A 1 69  ? -11.528 -60.449 -6.941  0.44 29.94  ? 332  TRP A CA  1 
ATOM   451  C  C   . TRP A 1 69  ? -11.615 -59.868 -5.524  0.44 31.07  ? 332  TRP A C   1 
ATOM   452  O  O   . TRP A 1 69  ? -11.126 -58.742 -5.323  0.44 33.36  ? 332  TRP A O   1 
ATOM   453  C  CB  . TRP A 1 69  ? -12.206 -59.582 -8.005  0.44 30.60  ? 332  TRP A CB  1 
ATOM   454  C  CG  . TRP A 1 69  ? -11.826 -60.025 -9.383  0.44 29.62  ? 332  TRP A CG  1 
ATOM   455  C  CD1 . TRP A 1 69  ? -10.750 -59.597 -10.103 0.44 29.88  ? 332  TRP A CD1 1 
ATOM   456  C  CD2 . TRP A 1 69  ? -12.471 -61.029 -10.185 0.44 30.26  ? 332  TRP A CD2 1 
ATOM   457  N  NE1 . TRP A 1 69  ? -10.690 -60.252 -11.302 0.44 30.11  ? 332  TRP A NE1 1 
ATOM   458  C  CE2 . TRP A 1 69  ? -11.734 -61.133 -11.384 0.44 29.92  ? 332  TRP A CE2 1 
ATOM   459  C  CE3 . TRP A 1 69  ? -13.606 -61.834 -10.025 0.44 30.44  ? 332  TRP A CE3 1 
ATOM   460  C  CZ2 . TRP A 1 69  ? -12.093 -62.008 -12.406 0.44 29.78  ? 332  TRP A CZ2 1 
ATOM   461  C  CZ3 . TRP A 1 69  ? -13.961 -62.699 -11.035 0.44 29.62  ? 332  TRP A CZ3 1 
ATOM   462  C  CH2 . TRP A 1 69  ? -13.209 -62.788 -12.206 0.44 30.15  ? 332  TRP A CH2 1 
ATOM   463  N  N   . ASP A 1 70  ? -12.146 -60.624 -4.559  0.44 30.45  ? 333  ASP A N   1 
ATOM   464  C  CA  . ASP A 1 70  ? -12.216 -60.201 -3.136  0.44 30.14  ? 333  ASP A CA  1 
ATOM   465  C  C   . ASP A 1 70  ? -10.805 -60.147 -2.523  0.44 30.76  ? 333  ASP A C   1 
ATOM   466  O  O   . ASP A 1 70  ? -10.660 -59.557 -1.426  0.44 30.83  ? 333  ASP A O   1 
ATOM   467  C  CB  . ASP A 1 70  ? -13.135 -61.132 -2.337  0.44 30.28  ? 333  ASP A CB  1 
ATOM   468  C  CG  . ASP A 1 70  ? -14.622 -60.979 -2.643  0.44 31.59  ? 333  ASP A CG  1 
ATOM   469  O  OD1 . ASP A 1 70  ? -14.984 -60.050 -3.410  0.44 29.91  ? 333  ASP A OD1 1 
ATOM   470  O  OD2 . ASP A 1 70  ? -15.415 -61.783 -2.094  0.44 29.15  ? 333  ASP A OD2 1 
ATOM   471  N  N   . ILE A 1 71  ? -9.812  -60.771 -3.168  0.44 31.68  ? 334  ILE A N   1 
ATOM   472  C  CA  . ILE A 1 71  ? -8.428  -60.915 -2.627  0.44 31.95  ? 334  ILE A CA  1 
ATOM   473  C  C   . ILE A 1 71  ? -7.428  -60.176 -3.530  0.44 33.85  ? 334  ILE A C   1 
ATOM   474  O  O   . ILE A 1 71  ? -6.217  -60.291 -3.252  0.44 36.08  ? 334  ILE A O   1 
ATOM   475  C  CB  . ILE A 1 71  ? -8.061  -62.403 -2.425  0.44 32.81  ? 334  ILE A CB  1 
ATOM   476  C  CG1 . ILE A 1 71  ? -8.140  -63.218 -3.717  0.44 34.02  ? 334  ILE A CG1 1 
ATOM   477  C  CG2 . ILE A 1 71  ? -8.906  -63.024 -1.324  0.44 32.30  ? 334  ILE A CG2 1 
ATOM   478  C  CD1 . ILE A 1 71  ? -7.438  -64.550 -3.635  0.44 36.60  ? 334  ILE A CD1 1 
ATOM   479  N  N   . ILE A 1 72  ? -7.907  -59.433 -4.540  0.44 34.04  ? 335  ILE A N   1 
ATOM   480  C  CA  . ILE A 1 72  ? -7.077  -58.622 -5.478  0.44 33.33  ? 335  ILE A CA  1 
ATOM   481  C  C   . ILE A 1 72  ? -7.067  -57.180 -4.981  0.44 35.55  ? 335  ILE A C   1 
ATOM   482  O  O   . ILE A 1 72  ? -8.050  -56.464 -5.161  0.44 32.25  ? 335  ILE A O   1 
ATOM   483  C  CB  . ILE A 1 72  ? -7.615  -58.707 -6.918  0.44 36.14  ? 335  ILE A CB  1 
ATOM   484  C  CG1 . ILE A 1 72  ? -7.744  -60.152 -7.409  0.44 36.93  ? 335  ILE A CG1 1 
ATOM   485  C  CG2 . ILE A 1 72  ? -6.773  -57.858 -7.861  0.44 35.15  ? 335  ILE A CG2 1 
ATOM   486  C  CD1 . ILE A 1 72  ? -6.436  -60.893 -7.492  0.44 39.60  ? 335  ILE A CD1 1 
ATOM   487  N  N   . PRO A 1 73  ? -5.962  -56.715 -4.346  0.44 36.66  ? 336  PRO A N   1 
ATOM   488  C  CA  . PRO A 1 73  ? -5.873  -55.354 -3.813  0.44 37.48  ? 336  PRO A CA  1 
ATOM   489  C  C   . PRO A 1 73  ? -6.263  -54.237 -4.792  0.44 38.51  ? 336  PRO A C   1 
ATOM   490  O  O   . PRO A 1 73  ? -6.927  -53.308 -4.385  0.44 38.27  ? 336  PRO A O   1 
ATOM   491  C  CB  . PRO A 1 73  ? -4.384  -55.220 -3.453  0.44 40.00  ? 336  PRO A CB  1 
ATOM   492  C  CG  . PRO A 1 73  ? -3.989  -56.630 -3.078  0.44 40.27  ? 336  PRO A CG  1 
ATOM   493  C  CD  . PRO A 1 73  ? -4.753  -57.503 -4.058  0.44 38.62  ? 336  PRO A CD  1 
ATOM   494  N  N   . MET A 1 74  ? -5.864  -54.341 -6.055  0.44 38.35  ? 337  MET A N   1 
ATOM   495  C  CA  . MET A 1 74  ? -6.214  -53.303 -7.054  0.44 40.20  ? 337  MET A CA  1 
ATOM   496  C  C   . MET A 1 74  ? -7.740  -53.124 -7.049  0.44 38.24  ? 337  MET A C   1 
ATOM   497  O  O   . MET A 1 74  ? -8.179  -51.964 -6.982  0.44 36.34  ? 337  MET A O   1 
ATOM   498  C  CB  . MET A 1 74  ? -5.685  -53.660 -8.448  0.44 45.57  ? 337  MET A CB  1 
ATOM   499  C  CG  . MET A 1 74  ? -4.154  -53.633 -8.533  0.44 52.69  ? 337  MET A CG  1 
ATOM   500  S  SD  . MET A 1 74  ? -3.410  -52.020 -8.088  0.44 61.59  ? 337  MET A SD  1 
ATOM   501  C  CE  . MET A 1 74  ? -4.324  -50.942 -9.193  0.44 60.41  ? 337  MET A CE  1 
ATOM   502  N  N   . VAL A 1 75  ? -8.513  -54.220 -7.009  0.44 34.91  ? 338  VAL A N   1 
ATOM   503  C  CA  . VAL A 1 75  ? -10.011 -54.172 -7.018  0.44 33.30  ? 338  VAL A CA  1 
ATOM   504  C  C   . VAL A 1 75  ? -10.512 -53.651 -5.669  0.44 31.70  ? 338  VAL A C   1 
ATOM   505  O  O   . VAL A 1 75  ? -11.318 -52.723 -5.680  0.44 31.33  ? 338  VAL A O   1 
ATOM   506  C  CB  . VAL A 1 75  ? -10.655 -55.532 -7.360  0.44 32.75  ? 338  VAL A CB  1 
ATOM   507  C  CG1 . VAL A 1 75  ? -12.149 -55.559 -7.033  0.44 33.96  ? 338  VAL A CG1 1 
ATOM   508  C  CG2 . VAL A 1 75  ? -10.433 -55.892 -8.821  0.44 31.98  ? 338  VAL A CG2 1 
ATOM   509  N  N   . THR A 1 76  ? -10.066 -54.239 -4.561  0.44 32.11  ? 339  THR A N   1 
ATOM   510  C  CA  . THR A 1 76  ? -10.621 -53.986 -3.206  0.44 34.79  ? 339  THR A CA  1 
ATOM   511  C  C   . THR A 1 76  ? -10.298 -52.556 -2.768  0.44 35.50  ? 339  THR A C   1 
ATOM   512  O  O   . THR A 1 76  ? -11.153 -51.941 -2.117  0.44 35.60  ? 339  THR A O   1 
ATOM   513  C  CB  . THR A 1 76  ? -10.122 -55.023 -2.191  0.44 37.28  ? 339  THR A CB  1 
ATOM   514  O  OG1 . THR A 1 76  ? -8.694  -55.016 -2.167  0.44 36.34  ? 339  THR A OG1 1 
ATOM   515  C  CG2 . THR A 1 76  ? -10.597 -56.423 -2.513  0.44 38.03  ? 339  THR A CG2 1 
ATOM   516  N  N   . GLN A 1 77  ? -9.124  -52.035 -3.126  0.44 37.03  ? 340  GLN A N   1 
ATOM   517  C  CA  . GLN A 1 77  ? -8.647  -50.713 -2.639  0.44 40.10  ? 340  GLN A CA  1 
ATOM   518  C  C   . GLN A 1 77  ? -9.425  -49.591 -3.333  0.44 35.89  ? 340  GLN A C   1 
ATOM   519  O  O   . GLN A 1 77  ? -9.520  -48.518 -2.734  0.44 35.92  ? 340  GLN A O   1 
ATOM   520  C  CB  . GLN A 1 77  ? -7.138  -50.565 -2.842  0.44 43.11  ? 340  GLN A CB  1 
ATOM   521  C  CG  . GLN A 1 77  ? -6.328  -51.664 -2.168  0.44 49.73  ? 340  GLN A CG  1 
ATOM   522  C  CD  . GLN A 1 77  ? -6.020  -51.398 -0.717  0.44 57.88  ? 340  GLN A CD  1 
ATOM   523  O  OE1 . GLN A 1 77  ? -6.749  -50.689 -0.025  0.44 64.61  ? 340  GLN A OE1 1 
ATOM   524  N  NE2 . GLN A 1 77  ? -4.929  -51.984 -0.242  0.44 63.94  ? 340  GLN A NE2 1 
ATOM   525  N  N   . MET A 1 78  ? -9.971  -49.829 -4.532  0.44 35.37  ? 341  MET A N   1 
ATOM   526  C  CA  . MET A 1 78  ? -10.757 -48.815 -5.293  0.44 38.32  ? 341  MET A CA  1 
ATOM   527  C  C   . MET A 1 78  ? -12.007 -48.392 -4.510  0.44 38.97  ? 341  MET A C   1 
ATOM   528  O  O   . MET A 1 78  ? -12.457 -47.255 -4.723  0.44 38.32  ? 341  MET A O   1 
ATOM   529  C  CB  . MET A 1 78  ? -11.212 -49.336 -6.658  0.44 39.61  ? 341  MET A CB  1 
ATOM   530  C  CG  . MET A 1 78  ? -10.110 -49.378 -7.695  0.44 43.03  ? 341  MET A CG  1 
ATOM   531  S  SD  . MET A 1 78  ? -10.737 -49.797 -9.349  0.44 46.80  ? 341  MET A SD  1 
ATOM   532  C  CE  . MET A 1 78  ? -12.103 -48.644 -9.469  0.44 43.52  ? 341  MET A CE  1 
ATOM   533  N  N   . ALA A 1 79  ? -12.567 -49.265 -3.663  0.44 39.91  ? 342  ALA A N   1 
ATOM   534  C  CA  . ALA A 1 79  ? -13.825 -49.006 -2.917  0.44 41.11  ? 342  ALA A CA  1 
ATOM   535  C  C   . ALA A 1 79  ? -13.555 -48.271 -1.592  0.44 42.31  ? 342  ALA A C   1 
ATOM   536  O  O   . ALA A 1 79  ? -14.536 -47.848 -0.964  0.44 40.44  ? 342  ALA A O   1 
ATOM   537  C  CB  . ALA A 1 79  ? -14.557 -50.308 -2.686  0.44 41.50  ? 342  ALA A CB  1 
ATOM   538  N  N   . MET A 1 80  ? -12.291 -48.109 -1.185  0.44 45.69  ? 343  MET A N   1 
ATOM   539  C  CA  . MET A 1 80  ? -11.916 -47.496 0.121   0.44 52.54  ? 343  MET A CA  1 
ATOM   540  C  C   . MET A 1 80  ? -11.664 -45.992 -0.060  0.44 57.84  ? 343  MET A C   1 
ATOM   541  O  O   . MET A 1 80  ? -11.036 -45.620 -1.073  0.44 60.44  ? 343  MET A O   1 
ATOM   542  C  CB  . MET A 1 80  ? -10.649 -48.143 0.689   0.44 53.74  ? 343  MET A CB  1 
ATOM   543  C  CG  . MET A 1 80  ? -10.726 -49.659 0.817   0.44 56.87  ? 343  MET A CG  1 
ATOM   544  S  SD  . MET A 1 80  ? -11.992 -50.270 1.981   0.44 58.73  ? 343  MET A SD  1 
ATOM   545  C  CE  . MET A 1 80  ? -11.458 -49.511 3.515   0.44 55.34  ? 343  MET A CE  1 
ATOM   546  N  N   . THR A 1 81  ? -12.116 -45.167 0.895   0.44 65.87  ? 344  THR A N   1 
ATOM   547  C  CA  . THR A 1 81  ? -11.808 -43.720 0.951   0.44 67.40  ? 344  THR A CA  1 
ATOM   548  C  C   . THR A 1 81  ? -12.747 -42.964 1.876   0.44 67.17  ? 344  THR A C   1 
ATOM   549  O  O   . THR A 1 81  ? -13.971 -43.036 1.628   0.44 69.22  ? 344  THR A O   1 
ATOM   550  N  N   . GLU A 1 94  ? -3.725  -28.212 -4.913  0.44 116.63 ? 357  GLU A N   1 
ATOM   551  C  CA  . GLU A 1 94  ? -2.523  -27.335 -4.946  0.44 116.78 ? 357  GLU A CA  1 
ATOM   552  C  C   . GLU A 1 94  ? -2.311  -26.841 -6.379  0.44 115.51 ? 357  GLU A C   1 
ATOM   553  O  O   . GLU A 1 94  ? -1.899  -25.678 -6.543  0.44 112.31 ? 357  GLU A O   1 
ATOM   554  C  CB  . GLU A 1 94  ? -1.300  -28.082 -4.410  0.44 116.32 ? 357  GLU A CB  1 
ATOM   555  C  CG  . GLU A 1 94  ? -1.295  -28.227 -2.897  0.44 115.52 ? 357  GLU A CG  1 
ATOM   556  C  CD  . GLU A 1 94  ? -2.499  -28.936 -2.299  0.44 116.89 ? 357  GLU A CD  1 
ATOM   557  O  OE1 . GLU A 1 94  ? -2.347  -30.096 -1.869  0.44 117.27 ? 357  GLU A OE1 1 
ATOM   558  O  OE2 . GLU A 1 94  ? -3.585  -28.323 -2.252  0.44 115.40 ? 357  GLU A OE2 1 
ATOM   559  N  N   . LYS A 1 95  ? -2.586  -27.692 -7.372  0.44 116.64 ? 358  LYS A N   1 
ATOM   560  C  CA  . LYS A 1 95  ? -2.498  -27.254 -8.790  0.44 114.67 ? 358  LYS A CA  1 
ATOM   561  C  C   . LYS A 1 95  ? -3.502  -26.120 -9.010  0.44 111.53 ? 358  LYS A C   1 
ATOM   562  O  O   . LYS A 1 95  ? -3.187  -25.189 -9.771  0.44 107.50 ? 358  LYS A O   1 
ATOM   563  C  CB  . LYS A 1 95  ? -2.811  -28.425 -9.725  0.44 113.94 ? 358  LYS A CB  1 
ATOM   564  C  CG  . LYS A 1 95  ? -2.925  -28.065 -11.200 0.44 113.36 ? 358  LYS A CG  1 
ATOM   565  C  CD  . LYS A 1 95  ? -1.608  -27.656 -11.817 0.44 113.48 ? 358  LYS A CD  1 
ATOM   566  C  CE  . LYS A 1 95  ? -0.633  -28.809 -11.912 0.44 114.67 ? 358  LYS A CE  1 
ATOM   567  N  NZ  . LYS A 1 95  ? -1.170  -29.908 -12.748 0.44 114.07 ? 358  LYS A NZ  1 
ATOM   568  N  N   . VAL A 1 96  ? -4.665  -26.203 -8.362  0.44 109.56 ? 359  VAL A N   1 
ATOM   569  C  CA  . VAL A 1 96  ? -5.729  -25.174 -8.557  0.44 109.14 ? 359  VAL A CA  1 
ATOM   570  C  C   . VAL A 1 96  ? -5.193  -23.808 -8.118  0.44 105.32 ? 359  VAL A C   1 
ATOM   571  O  O   . VAL A 1 96  ? -5.378  -22.835 -8.868  0.44 103.39 ? 359  VAL A O   1 
ATOM   572  C  CB  . VAL A 1 96  ? -7.012  -25.549 -7.791  0.44 109.71 ? 359  VAL A CB  1 
ATOM   573  C  CG1 . VAL A 1 96  ? -6.715  -25.944 -6.353  0.44 111.01 ? 359  VAL A CG1 1 
ATOM   574  C  CG2 . VAL A 1 96  ? -8.049  -24.438 -7.845  0.44 108.68 ? 359  VAL A CG2 1 
ATOM   575  N  N   . ASP A 1 97  ? -4.550  -23.745 -6.952  0.44 102.03 ? 360  ASP A N   1 
ATOM   576  C  CA  . ASP A 1 97  ? -4.042  -22.448 -6.435  0.44 101.91 ? 360  ASP A CA  1 
ATOM   577  C  C   . ASP A 1 97  ? -2.687  -22.159 -7.093  0.44 105.50 ? 360  ASP A C   1 
ATOM   578  O  O   . ASP A 1 97  ? -1.698  -21.998 -6.355  0.44 108.30 ? 360  ASP A O   1 
ATOM   579  C  CB  . ASP A 1 97  ? -3.994  -22.447 -4.903  0.44 97.95  ? 360  ASP A CB  1 
ATOM   580  C  CG  . ASP A 1 97  ? -4.039  -21.062 -4.279  0.44 94.78  ? 360  ASP A CG  1 
ATOM   581  O  OD1 . ASP A 1 97  ? -3.755  -20.084 -4.993  0.44 90.00  ? 360  ASP A OD1 1 
ATOM   582  O  OD2 . ASP A 1 97  ? -4.365  -20.974 -3.080  0.44 93.58  ? 360  ASP A OD2 1 
ATOM   583  N  N   . THR A 1 98  ? -2.652  -22.096 -8.429  0.50 106.65 ? 361  THR A N   1 
ATOM   584  C  CA  . THR A 1 98  ? -1.397  -21.775 -9.159  0.50 108.07 ? 361  THR A CA  1 
ATOM   585  C  C   . THR A 1 98  ? -1.679  -20.695 -10.208 0.50 107.30 ? 361  THR A C   1 
ATOM   586  O  O   . THR A 1 98  ? -2.861  -20.489 -10.528 0.50 102.42 ? 361  THR A O   1 
ATOM   587  C  CB  . THR A 1 98  ? -0.793  -23.024 -9.812  0.50 109.64 ? 361  THR A CB  1 
ATOM   588  O  OG1 . THR A 1 98  ? -1.732  -23.530 -10.762 0.50 109.69 ? 361  THR A OG1 1 
ATOM   589  C  CG2 . THR A 1 98  ? -0.437  -24.101 -8.810  0.50 109.11 ? 361  THR A CG2 1 
ATOM   590  N  N   . ARG A 1 99  ? -0.631  -20.039 -10.717 0.44 108.94 ? 362  ARG A N   1 
ATOM   591  C  CA  . ARG A 1 99  ? -0.799  -18.992 -11.761 0.44 111.19 ? 362  ARG A CA  1 
ATOM   592  C  C   . ARG A 1 99  ? -0.460  -19.565 -13.140 0.44 110.95 ? 362  ARG A C   1 
ATOM   593  O  O   . ARG A 1 99  ? 0.008   -20.716 -13.200 0.44 114.22 ? 362  ARG A O   1 
ATOM   594  C  CB  . ARG A 1 99  ? 0.104   -17.788 -11.477 0.44 112.88 ? 362  ARG A CB  1 
ATOM   595  C  CG  . ARG A 1 99  ? -0.490  -16.769 -10.516 0.44 115.12 ? 362  ARG A CG  1 
ATOM   596  C  CD  . ARG A 1 99  ? 0.353   -15.510 -10.523 0.44 116.53 ? 362  ARG A CD  1 
ATOM   597  N  NE  . ARG A 1 99  ? 0.669   -15.120 -11.890 0.44 119.06 ? 362  ARG A NE  1 
ATOM   598  C  CZ  . ARG A 1 99  ? 1.438   -14.092 -12.225 0.44 120.60 ? 362  ARG A CZ  1 
ATOM   599  N  NH1 . ARG A 1 99  ? 1.981   -13.335 -11.286 0.44 121.03 ? 362  ARG A NH1 1 
ATOM   600  N  NH2 . ARG A 1 99  ? 1.664   -13.825 -13.499 0.44 121.01 ? 362  ARG A NH2 1 
ATOM   601  N  N   . THR A 1 100 ? -0.693  -18.784 -14.200 0.44 109.06 ? 363  THR A N   1 
ATOM   602  C  CA  . THR A 1 100 ? -0.366  -19.232 -15.579 0.44 106.62 ? 363  THR A CA  1 
ATOM   603  C  C   . THR A 1 100 ? 0.218   -18.054 -16.360 0.44 104.57 ? 363  THR A C   1 
ATOM   604  O  O   . THR A 1 100 ? -0.567  -17.210 -16.827 0.44 103.96 ? 363  THR A O   1 
ATOM   605  C  CB  . THR A 1 100 ? -1.592  -19.823 -16.284 0.44 107.73 ? 363  THR A CB  1 
ATOM   606  O  OG1 . THR A 1 100 ? -2.128  -20.849 -15.449 0.44 108.91 ? 363  THR A OG1 1 
ATOM   607  C  CG2 . THR A 1 100 ? -1.264  -20.390 -17.648 0.44 107.77 ? 363  THR A CG2 1 
ATOM   608  N  N   . GLN A 1 101 ? 1.543   -18.010 -16.494 0.50 104.61 ? 364  GLN A N   1 
ATOM   609  C  CA  . GLN A 1 101 ? 2.226   -16.903 -17.212 0.50 105.61 ? 364  GLN A CA  1 
ATOM   610  C  C   . GLN A 1 101 ? 1.444   -16.569 -18.488 0.50 98.58  ? 364  GLN A C   1 
ATOM   611  O  O   . GLN A 1 101 ? 1.007   -17.509 -19.181 0.50 102.48 ? 364  GLN A O   1 
ATOM   612  C  CB  . GLN A 1 101 ? 3.671   -17.282 -17.539 0.50 111.99 ? 364  GLN A CB  1 
ATOM   613  C  CG  . GLN A 1 101 ? 4.435   -16.176 -18.253 0.50 117.84 ? 364  GLN A CG  1 
ATOM   614  C  CD  . GLN A 1 101 ? 5.883   -16.530 -18.488 0.50 122.64 ? 364  GLN A CD  1 
ATOM   615  O  OE1 . GLN A 1 101 ? 6.359   -17.587 -18.078 0.50 125.36 ? 364  GLN A OE1 1 
ATOM   616  N  NE2 . GLN A 1 101 ? 6.599   -15.639 -19.157 0.50 125.26 ? 364  GLN A NE2 1 
ATOM   617  N  N   . GLU A 1 102 ? 1.277   -15.276 -18.776 0.50 88.85  ? 365  GLU A N   1 
ATOM   618  C  CA  . GLU A 1 102 ? 0.660   -14.765 -20.027 0.50 83.04  ? 365  GLU A CA  1 
ATOM   619  C  C   . GLU A 1 102 ? 1.515   -15.213 -21.209 0.50 77.18  ? 365  GLU A C   1 
ATOM   620  O  O   . GLU A 1 102 ? 2.732   -15.035 -21.217 0.50 73.53  ? 365  GLU A O   1 
ATOM   621  C  CB  . GLU A 1 102 ? 0.526   -13.241 -19.974 0.50 85.91  ? 365  GLU A CB  1 
ATOM   622  C  CG  . GLU A 1 102 ? -0.007  -12.617 -21.257 0.50 88.83  ? 365  GLU A CG  1 
ATOM   623  C  CD  . GLU A 1 102 ? -1.509  -12.366 -21.311 0.50 88.39  ? 365  GLU A CD  1 
ATOM   624  O  OE1 . GLU A 1 102 ? -1.947  -11.562 -22.165 0.50 84.70  ? 365  GLU A OE1 1 
ATOM   625  O  OE2 . GLU A 1 102 ? -2.242  -12.968 -20.504 0.50 86.10  ? 365  GLU A OE2 1 
ATOM   626  N  N   . PRO A 1 103 ? 0.896   -15.820 -22.244 0.50 70.52  ? 366  PRO A N   1 
ATOM   627  C  CA  . PRO A 1 103 ? 1.630   -16.265 -23.426 0.50 67.48  ? 366  PRO A CA  1 
ATOM   628  C  C   . PRO A 1 103 ? 2.392   -15.086 -24.045 0.50 63.90  ? 366  PRO A C   1 
ATOM   629  O  O   . PRO A 1 103 ? 2.039   -13.968 -23.736 0.50 60.26  ? 366  PRO A O   1 
ATOM   630  C  CB  . PRO A 1 103 ? 0.535   -16.783 -24.372 0.50 66.47  ? 366  PRO A CB  1 
ATOM   631  C  CG  . PRO A 1 103 ? -0.631  -17.106 -23.455 0.50 69.43  ? 366  PRO A CG  1 
ATOM   632  C  CD  . PRO A 1 103 ? -0.545  -16.091 -22.335 0.50 69.67  ? 366  PRO A CD  1 
ATOM   633  N  N   . LYS A 1 104 ? 3.396   -15.371 -24.881 0.34 61.91  ? 367  LYS A N   1 
ATOM   634  C  CA  . LYS A 1 104 ? 4.150   -14.366 -25.678 0.34 61.90  ? 367  LYS A CA  1 
ATOM   635  C  C   . LYS A 1 104 ? 3.233   -13.827 -26.780 0.34 59.46  ? 367  LYS A C   1 
ATOM   636  O  O   . LYS A 1 104 ? 2.188   -14.449 -27.030 0.34 58.92  ? 367  LYS A O   1 
ATOM   637  C  CB  . LYS A 1 104 ? 5.411   -14.984 -26.291 0.34 63.46  ? 367  LYS A CB  1 
ATOM   638  C  CG  . LYS A 1 104 ? 6.372   -15.631 -25.302 0.34 64.35  ? 367  LYS A CG  1 
ATOM   639  C  CD  . LYS A 1 104 ? 6.647   -14.781 -24.086 0.34 66.66  ? 367  LYS A CD  1 
ATOM   640  C  CE  . LYS A 1 104 ? 7.632   -15.417 -23.130 0.34 68.62  ? 367  LYS A CE  1 
ATOM   641  N  NZ  . LYS A 1 104 ? 7.657   -14.707 -21.829 0.34 69.25  ? 367  LYS A NZ  1 
ATOM   642  N  N   . GLU A 1 105 ? 3.633   -12.732 -27.429 0.34 58.18  ? 368  GLU A N   1 
ATOM   643  C  CA  . GLU A 1 105 ? 2.829   -12.015 -28.455 0.34 58.87  ? 368  GLU A CA  1 
ATOM   644  C  C   . GLU A 1 105 ? 2.572   -12.931 -29.654 0.34 56.15  ? 368  GLU A C   1 
ATOM   645  O  O   . GLU A 1 105 ? 1.412   -13.001 -30.102 0.34 58.23  ? 368  GLU A O   1 
ATOM   646  C  CB  . GLU A 1 105 ? 3.552   -10.740 -28.888 0.34 62.00  ? 368  GLU A CB  1 
ATOM   647  C  CG  . GLU A 1 105 ? 3.509   -9.657  -27.829 0.34 64.29  ? 368  GLU A CG  1 
ATOM   648  C  CD  . GLU A 1 105 ? 2.123   -9.452  -27.241 0.34 65.91  ? 368  GLU A CD  1 
ATOM   649  O  OE1 . GLU A 1 105 ? 1.147   -9.445  -28.023 0.34 69.77  ? 368  GLU A OE1 1 
ATOM   650  O  OE2 . GLU A 1 105 ? 2.018   -9.322  -26.005 0.34 65.60  ? 368  GLU A OE2 1 
ATOM   651  N  N   . GLY A 1 106 ? 3.624   -13.576 -30.161 0.50 53.23  ? 369  GLY A N   1 
ATOM   652  C  CA  . GLY A 1 106 ? 3.559   -14.523 -31.291 0.50 50.63  ? 369  GLY A CA  1 
ATOM   653  C  C   . GLY A 1 106 ? 2.618   -15.681 -30.992 0.50 50.91  ? 369  GLY A C   1 
ATOM   654  O  O   . GLY A 1 106 ? 1.887   -16.086 -31.914 0.50 49.35  ? 369  GLY A O   1 
ATOM   655  N  N   . THR A 1 107 ? 2.644   -16.202 -29.757 1.00 45.83  ? 370  THR A N   1 
ATOM   656  C  CA  . THR A 1 107 ? 1.736   -17.288 -29.303 1.00 52.44  ? 370  THR A CA  1 
ATOM   657  C  C   . THR A 1 107 ? 0.269   -16.819 -29.353 1.00 49.93  ? 370  THR A C   1 
ATOM   658  O  O   . THR A 1 107 ? -0.565  -17.496 -30.007 1.00 47.56  ? 370  THR A O   1 
ATOM   659  C  CB  . THR A 1 107 ? 2.090   -17.767 -27.895 1.00 50.80  ? 370  THR A CB  1 
ATOM   660  O  OG1 . THR A 1 107 ? 3.505   -17.952 -27.864 1.00 50.37  ? 370  THR A OG1 1 
ATOM   661  C  CG2 . THR A 1 107 ? 1.379   -19.058 -27.553 1.00 47.34  ? 370  THR A CG2 1 
ATOM   662  N  N   . LYS A 1 108 ? -0.015  -15.670 -28.739 1.00 55.24  ? 371  LYS A N   1 
ATOM   663  C  CA  . LYS A 1 108 ? -1.347  -14.990 -28.732 1.00 52.93  ? 371  LYS A CA  1 
ATOM   664  C  C   . LYS A 1 108 ? -1.932  -14.795 -30.149 1.00 51.39  ? 371  LYS A C   1 
ATOM   665  O  O   . LYS A 1 108 ? -3.140  -15.029 -30.341 1.00 49.77  ? 371  LYS A O   1 
ATOM   666  C  CB  . LYS A 1 108 ? -1.232  -13.687 -27.941 1.00 52.64  ? 371  LYS A CB  1 
ATOM   667  C  CG  . LYS A 1 108 ? -1.007  -13.892 -26.449 1.00 55.82  ? 371  LYS A CG  1 
ATOM   668  C  CD  . LYS A 1 108 ? -1.431  -12.719 -25.592 1.00 60.58  ? 371  LYS A CD  1 
ATOM   669  C  CE  . LYS A 1 108 ? -0.439  -11.582 -25.587 1.00 68.71  ? 371  LYS A CE  1 
ATOM   670  N  NZ  . LYS A 1 108 ? -0.528  -10.808 -24.327 1.00 77.39  ? 371  LYS A NZ  1 
ATOM   671  N  N   . LYS A 1 109 ? -1.095  -14.414 -31.114 0.50 51.23  ? 372  LYS A N   1 
ATOM   672  C  CA  . LYS A 1 109 ? -1.564  -14.204 -32.509 0.50 54.73  ? 372  LYS A CA  1 
ATOM   673  C  C   . LYS A 1 109 ? -1.873  -15.556 -33.155 0.50 55.81  ? 372  LYS A C   1 
ATOM   674  O  O   . LYS A 1 109 ? -2.904  -15.655 -33.843 0.50 55.28  ? 372  LYS A O   1 
ATOM   675  C  CB  . LYS A 1 109 ? -0.492  -13.466 -33.312 0.50 61.37  ? 372  LYS A CB  1 
ATOM   676  C  CG  . LYS A 1 109 ? -0.795  -13.267 -34.791 0.50 69.01  ? 372  LYS A CG  1 
ATOM   677  C  CD  . LYS A 1 109 ? -1.922  -12.290 -35.046 0.50 76.64  ? 372  LYS A CD  1 
ATOM   678  C  CE  . LYS A 1 109 ? -1.616  -10.895 -34.546 0.50 81.54  ? 372  LYS A CE  1 
ATOM   679  N  NZ  . LYS A 1 109 ? -2.756  -9.971  -34.759 0.50 82.42  ? 372  LYS A NZ  1 
ATOM   680  N  N   . LEU A 1 110 ? -1.003  -16.545 -32.950 1.00 54.15  ? 373  LEU A N   1 
ATOM   681  C  CA  . LEU A 1 110 ? -1.176  -17.912 -33.530 1.00 48.93  ? 373  LEU A CA  1 
ATOM   682  C  C   . LEU A 1 110 ? -2.522  -18.466 -33.033 1.00 38.68  ? 373  LEU A C   1 
ATOM   683  O  O   . LEU A 1 110 ? -3.232  -19.063 -33.820 1.00 37.21  ? 373  LEU A O   1 
ATOM   684  C  CB  . LEU A 1 110 ? -0.034  -18.834 -33.070 1.00 47.96  ? 373  LEU A CB  1 
ATOM   685  C  CG  . LEU A 1 110 ? 1.343   -18.680 -33.737 1.00 48.67  ? 373  LEU A CG  1 
ATOM   686  C  CD1 . LEU A 1 110 ? 2.420   -19.345 -32.878 1.00 43.82  ? 373  LEU A CD1 1 
ATOM   687  C  CD2 . LEU A 1 110 ? 1.348   -19.250 -35.160 1.00 50.57  ? 373  LEU A CD2 1 
ATOM   688  N  N   . MET A 1 111 ? -2.818  -18.253 -31.760 1.00 31.38  ? 374  MET A N   1 
ATOM   689  C  CA  . MET A 1 111 ? -4.032  -18.761 -31.084 1.00 42.28  ? 374  MET A CA  1 
ATOM   690  C  C   . MET A 1 111 ? -5.257  -17.969 -31.609 1.00 50.22  ? 374  MET A C   1 
ATOM   691  O  O   . MET A 1 111 ? -6.302  -18.620 -31.888 1.00 42.45  ? 374  MET A O   1 
ATOM   692  C  CB  . MET A 1 111 ? -3.923  -18.622 -29.551 1.00 43.22  ? 374  MET A CB  1 
ATOM   693  C  CG  . MET A 1 111 ? -3.022  -19.664 -28.874 1.00 38.20  ? 374  MET A CG  1 
ATOM   694  S  SD  . MET A 1 111 ? -3.170  -19.720 -27.052 1.00 45.54  ? 374  MET A SD  1 
ATOM   695  C  CE  . MET A 1 111 ? -2.750  -18.046 -26.594 1.00 47.83  ? 374  MET A CE  1 
ATOM   696  N  N   . LYS A 1 112 ? -5.144  -16.640 -31.766 1.00 43.21  ? 375  LYS A N   1 
ATOM   697  C  CA  . LYS A 1 112 ? -6.253  -15.770 -32.245 1.00 48.74  ? 375  LYS A CA  1 
ATOM   698  C  C   . LYS A 1 112 ? -6.587  -16.157 -33.696 1.00 46.17  ? 375  LYS A C   1 
ATOM   699  O  O   . LYS A 1 112 ? -7.763  -16.405 -33.987 1.00 42.53  ? 375  LYS A O   1 
ATOM   700  C  CB  . LYS A 1 112 ? -5.901  -14.281 -32.137 1.00 56.29  ? 375  LYS A CB  1 
ATOM   701  C  CG  . LYS A 1 112 ? -6.997  -13.352 -31.608 1.00 65.18  ? 375  LYS A CG  1 
ATOM   702  C  CD  . LYS A 1 112 ? -6.812  -13.006 -30.125 1.00 73.00  ? 375  LYS A CD  1 
ATOM   703  C  CE  . LYS A 1 112 ? -8.094  -12.713 -29.365 1.00 80.09  ? 375  LYS A CE  1 
ATOM   704  N  NZ  . LYS A 1 112 ? -7.949  -13.008 -27.915 1.00 81.09  ? 375  LYS A NZ  1 
ATOM   705  N  N   . ILE A 1 113 ? -5.589  -16.269 -34.563 1.00 43.00  ? 376  ILE A N   1 
ATOM   706  C  CA  . ILE A 1 113 ? -5.807  -16.641 -35.991 1.00 46.72  ? 376  ILE A CA  1 
ATOM   707  C  C   . ILE A 1 113 ? -6.426  -18.031 -36.075 1.00 44.14  ? 376  ILE A C   1 
ATOM   708  O  O   . ILE A 1 113 ? -7.234  -18.251 -37.030 1.00 44.68  ? 376  ILE A O   1 
ATOM   709  C  CB  . ILE A 1 113 ? -4.511  -16.605 -36.818 1.00 45.19  ? 376  ILE A CB  1 
ATOM   710  C  CG1 . ILE A 1 113 ? -3.999  -15.181 -37.015 1.00 56.23  ? 376  ILE A CG1 1 
ATOM   711  C  CG2 . ILE A 1 113 ? -4.684  -17.281 -38.160 1.00 44.59  ? 376  ILE A CG2 1 
ATOM   712  C  CD1 . ILE A 1 113 ? -2.527  -15.136 -37.332 1.00 63.16  ? 376  ILE A CD1 1 
ATOM   713  N  N   . THR A 1 114 ? -5.964  -18.959 -35.225 1.00 42.83  ? 377  THR A N   1 
ATOM   714  C  CA  . THR A 1 114 ? -6.347  -20.398 -35.311 1.00 40.03  ? 377  THR A CA  1 
ATOM   715  C  C   . THR A 1 114 ? -7.799  -20.549 -34.841 1.00 30.98  ? 377  THR A C   1 
ATOM   716  O  O   . THR A 1 114 ? -8.570  -21.257 -35.497 1.00 31.49  ? 377  THR A O   1 
ATOM   717  C  CB  . THR A 1 114 ? -5.343  -21.307 -34.581 1.00 38.64  ? 377  THR A CB  1 
ATOM   718  O  OG1 . THR A 1 114 ? -4.049  -21.123 -35.154 1.00 42.84  ? 377  THR A OG1 1 
ATOM   719  C  CG2 . THR A 1 114 ? -5.696  -22.766 -34.723 1.00 39.25  ? 377  THR A CG2 1 
ATOM   720  N  N   . ALA A 1 115 ? -8.143  -19.903 -33.733 1.00 37.49  ? 378  ALA A N   1 
ATOM   721  C  CA  . ALA A 1 115 ? -9.485  -19.856 -33.125 1.00 37.77  ? 378  ALA A CA  1 
ATOM   722  C  C   . ALA A 1 115 ? -10.523 -19.275 -34.109 1.00 44.25  ? 378  ALA A C   1 
ATOM   723  O  O   . ALA A 1 115 ? -11.597 -19.947 -34.407 1.00 40.29  ? 378  ALA A O   1 
ATOM   724  C  CB  . ALA A 1 115 ? -9.388  -19.047 -31.879 1.00 38.40  ? 378  ALA A CB  1 
ATOM   725  N  N   . GLU A 1 116 ? -10.217 -18.109 -34.669 1.00 43.43  ? 379  GLU A N   1 
ATOM   726  C  CA  . GLU A 1 116 ? -11.084 -17.462 -35.687 1.00 46.35  ? 379  GLU A CA  1 
ATOM   727  C  C   . GLU A 1 116 ? -11.339 -18.488 -36.809 1.00 44.04  ? 379  GLU A C   1 
ATOM   728  O  O   . GLU A 1 116 ? -12.497 -18.737 -37.180 1.00 44.69  ? 379  GLU A O   1 
ATOM   729  C  CB  . GLU A 1 116 ? -10.448 -16.154 -36.158 1.00 48.23  ? 379  GLU A CB  1 
ATOM   730  C  CG  . GLU A 1 116 ? -11.270 -15.405 -37.194 1.00 57.77  ? 379  GLU A CG  1 
ATOM   731  C  CD  . GLU A 1 116 ? -10.634 -14.171 -37.824 1.00 62.62  ? 379  GLU A CD  1 
ATOM   732  O  OE1 . GLU A 1 116 ? -9.393  -14.093 -37.846 1.00 68.70  ? 379  GLU A OE1 1 
ATOM   733  O  OE2 . GLU A 1 116 ? -11.388 -13.297 -38.306 1.00 76.56  ? 379  GLU A OE2 1 
ATOM   734  N  N   . TRP A 1 117 ? -10.303 -19.123 -37.320 1.00 39.44  ? 380  TRP A N   1 
ATOM   735  C  CA  . TRP A 1 117 ? -10.454 -20.061 -38.455 1.00 37.42  ? 380  TRP A CA  1 
ATOM   736  C  C   . TRP A 1 117 ? -11.299 -21.266 -38.002 1.00 42.16  ? 380  TRP A C   1 
ATOM   737  O  O   . TRP A 1 117 ? -12.086 -21.824 -38.824 1.00 36.63  ? 380  TRP A O   1 
ATOM   738  C  CB  . TRP A 1 117 ? -9.069  -20.478 -38.947 1.00 34.35  ? 380  TRP A CB  1 
ATOM   739  C  CG  . TRP A 1 117 ? -9.142  -21.553 -39.965 1.00 33.05  ? 380  TRP A CG  1 
ATOM   740  C  CD1 . TRP A 1 117 ? -9.311  -21.391 -41.296 1.00 34.15  ? 380  TRP A CD1 1 
ATOM   741  C  CD2 . TRP A 1 117 ? -9.139  -22.971 -39.727 1.00 39.55  ? 380  TRP A CD2 1 
ATOM   742  N  NE1 . TRP A 1 117 ? -9.330  -22.608 -41.914 1.00 38.83  ? 380  TRP A NE1 1 
ATOM   743  C  CE2 . TRP A 1 117 ? -9.258  -23.597 -40.972 1.00 34.84  ? 380  TRP A CE2 1 
ATOM   744  C  CE3 . TRP A 1 117 ? -9.022  -23.771 -38.586 1.00 39.84  ? 380  TRP A CE3 1 
ATOM   745  C  CZ2 . TRP A 1 117 ? -9.273  -24.982 -41.115 1.00 42.85  ? 380  TRP A CZ2 1 
ATOM   746  C  CZ3 . TRP A 1 117 ? -8.968  -25.133 -38.731 1.00 34.14  ? 380  TRP A CZ3 1 
ATOM   747  C  CH2 . TRP A 1 117 ? -9.143  -25.733 -39.970 1.00 39.52  ? 380  TRP A CH2 1 
ATOM   748  N  N   . LEU A 1 118 ? -11.143 -21.692 -36.747 1.00 41.20  ? 381  LEU A N   1 
ATOM   749  C  CA  . LEU A 1 118 ? -11.735 -22.982 -36.304 1.00 40.12  ? 381  LEU A CA  1 
ATOM   750  C  C   . LEU A 1 118 ? -13.245 -22.788 -36.069 1.00 34.04  ? 381  LEU A C   1 
ATOM   751  O  O   . LEU A 1 118 ? -14.017 -23.601 -36.559 1.00 32.45  ? 381  LEU A O   1 
ATOM   752  C  CB  . LEU A 1 118 ? -11.001 -23.475 -35.055 1.00 37.84  ? 381  LEU A CB  1 
ATOM   753  C  CG  . LEU A 1 118 ? -11.423 -24.866 -34.602 1.00 42.98  ? 381  LEU A CG  1 
ATOM   754  C  CD1 . LEU A 1 118 ? -11.246 -25.896 -35.723 1.00 39.15  ? 381  LEU A CD1 1 
ATOM   755  C  CD2 . LEU A 1 118 ? -10.674 -25.244 -33.333 1.00 44.52  ? 381  LEU A CD2 1 
ATOM   756  N  N   . TRP A 1 119 ? -13.645 -21.709 -35.394 1.00 34.97  ? 382  TRP A N   1 
ATOM   757  C  CA  . TRP A 1 119 ? -15.077 -21.364 -35.208 1.00 38.30  ? 382  TRP A CA  1 
ATOM   758  C  C   . TRP A 1 119 ? -15.780 -21.242 -36.583 1.00 44.67  ? 382  TRP A C   1 
ATOM   759  O  O   . TRP A 1 119 ? -16.896 -21.840 -36.766 1.00 46.85  ? 382  TRP A O   1 
ATOM   760  C  CB  . TRP A 1 119 ? -15.198 -20.107 -34.365 1.00 34.74  ? 382  TRP A CB  1 
ATOM   761  C  CG  . TRP A 1 119 ? -15.004 -20.311 -32.902 1.00 30.59  ? 382  TRP A CG  1 
ATOM   762  C  CD1 . TRP A 1 119 ? -14.248 -19.541 -32.076 1.00 34.28  ? 382  TRP A CD1 1 
ATOM   763  C  CD2 . TRP A 1 119 ? -15.685 -21.246 -32.054 1.00 32.47  ? 382  TRP A CD2 1 
ATOM   764  N  NE1 . TRP A 1 119 ? -14.412 -19.926 -30.773 1.00 35.79  ? 382  TRP A NE1 1 
ATOM   765  C  CE2 . TRP A 1 119 ? -15.288 -20.974 -30.732 1.00 33.05  ? 382  TRP A CE2 1 
ATOM   766  C  CE3 . TRP A 1 119 ? -16.634 -22.254 -32.273 1.00 34.16  ? 382  TRP A CE3 1 
ATOM   767  C  CZ2 . TRP A 1 119 ? -15.714 -21.744 -29.652 1.00 34.27  ? 382  TRP A CZ2 1 
ATOM   768  C  CZ3 . TRP A 1 119 ? -17.098 -22.982 -31.201 1.00 31.31  ? 382  TRP A CZ3 1 
ATOM   769  C  CH2 . TRP A 1 119 ? -16.620 -22.743 -29.914 1.00 32.60  ? 382  TRP A CH2 1 
ATOM   770  N  N   . LYS A 1 120 ? -15.139 -20.617 -37.571 1.00 39.49  ? 383  LYS A N   1 
ATOM   771  C  CA  . LYS A 1 120 ? -15.698 -20.573 -38.949 1.00 42.82  ? 383  LYS A CA  1 
ATOM   772  C  C   . LYS A 1 120 ? -15.861 -21.979 -39.509 1.00 41.25  ? 383  LYS A C   1 
ATOM   773  O  O   . LYS A 1 120 ? -16.915 -22.246 -40.107 1.00 46.21  ? 383  LYS A O   1 
ATOM   774  C  CB  . LYS A 1 120 ? -14.859 -19.749 -39.934 1.00 55.64  ? 383  LYS A CB  1 
ATOM   775  C  CG  . LYS A 1 120 ? -15.061 -18.245 -39.815 1.00 68.50  ? 383  LYS A CG  1 
ATOM   776  C  CD  . LYS A 1 120 ? -14.087 -17.386 -40.603 1.00 78.57  ? 383  LYS A CD  1 
ATOM   777  C  CE  . LYS A 1 120 ? -14.210 -15.918 -40.241 1.00 86.19  ? 383  LYS A CE  1 
ATOM   778  N  NZ  . LYS A 1 120 ? -12.929 -15.192 -40.421 1.00 94.48  ? 383  LYS A NZ  1 
ATOM   779  N  N   . GLU A 1 121 ? -14.886 -22.870 -39.369 1.00 36.97  ? 384  GLU A N   1 
ATOM   780  C  CA  . GLU A 1 121 ? -15.057 -24.230 -39.927 1.00 37.27  ? 384  GLU A CA  1 
ATOM   781  C  C   . GLU A 1 121 ? -16.178 -24.962 -39.195 1.00 36.66  ? 384  GLU A C   1 
ATOM   782  O  O   . GLU A 1 121 ? -16.897 -25.726 -39.862 1.00 40.21  ? 384  GLU A O   1 
ATOM   783  C  CB  . GLU A 1 121 ? -13.807 -25.079 -39.761 1.00 45.33  ? 384  GLU A CB  1 
ATOM   784  C  CG  . GLU A 1 121 ? -12.691 -24.589 -40.616 1.00 47.15  ? 384  GLU A CG  1 
ATOM   785  C  CD  . GLU A 1 121 ? -12.935 -24.769 -42.097 1.00 46.78  ? 384  GLU A CD  1 
ATOM   786  O  OE1 . GLU A 1 121 ? -13.361 -25.862 -42.531 1.00 46.98  ? 384  GLU A OE1 1 
ATOM   787  O  OE2 . GLU A 1 121 ? -12.641 -23.820 -42.803 1.00 49.94  ? 384  GLU A OE2 1 
ATOM   788  N  N   . LEU A 1 122 ? -16.291 -24.789 -37.873 1.00 35.46  ? 385  LEU A N   1 
ATOM   789  C  CA  . LEU A 1 122 ? -17.247 -25.592 -37.072 1.00 36.27  ? 385  LEU A CA  1 
ATOM   790  C  C   . LEU A 1 122 ? -18.644 -25.072 -37.437 1.00 41.85  ? 385  LEU A C   1 
ATOM   791  O  O   . LEU A 1 122 ? -19.599 -25.871 -37.389 1.00 38.05  ? 385  LEU A O   1 
ATOM   792  C  CB  . LEU A 1 122 ? -16.955 -25.456 -35.572 1.00 35.08  ? 385  LEU A CB  1 
ATOM   793  C  CG  . LEU A 1 122 ? -15.664 -26.126 -35.076 1.00 36.19  ? 385  LEU A CG  1 
ATOM   794  C  CD1 . LEU A 1 122 ? -15.513 -25.959 -33.577 1.00 34.46  ? 385  LEU A CD1 1 
ATOM   795  C  CD2 . LEU A 1 122 ? -15.670 -27.598 -35.411 1.00 35.05  ? 385  LEU A CD2 1 
ATOM   796  N  N   . GLY A 1 123 ? -18.711 -23.791 -37.824 1.00 42.83  ? 386  GLY A N   1 
ATOM   797  C  CA  . GLY A 1 123 ? -19.952 -23.040 -38.108 1.00 45.68  ? 386  GLY A CA  1 
ATOM   798  C  C   . GLY A 1 123 ? -20.408 -23.190 -39.540 1.00 43.56  ? 386  GLY A C   1 
ATOM   799  O  O   . GLY A 1 123 ? -21.549 -22.846 -39.819 1.00 52.27  ? 386  GLY A O   1 
ATOM   800  N  N   . LYS A 1 124 ? -19.594 -23.753 -40.425 1.00 41.59  ? 387  LYS A N   1 
ATOM   801  C  CA  . LYS A 1 124 ? -19.973 -23.869 -41.860 1.00 48.26  ? 387  LYS A CA  1 
ATOM   802  C  C   . LYS A 1 124 ? -21.324 -24.577 -42.018 1.00 49.02  ? 387  LYS A C   1 
ATOM   803  O  O   . LYS A 1 124 ? -22.093 -24.168 -42.873 1.00 54.21  ? 387  LYS A O   1 
ATOM   804  C  CB  . LYS A 1 124 ? -18.891 -24.582 -42.681 1.00 46.39  ? 387  LYS A CB  1 
ATOM   805  C  CG  . LYS A 1 124 ? -17.734 -23.683 -43.122 1.00 54.81  ? 387  LYS A CG  1 
ATOM   806  C  CD  . LYS A 1 124 ? -16.834 -24.304 -44.181 1.00 60.66  ? 387  LYS A CD  1 
ATOM   807  C  CE  . LYS A 1 124 ? -15.500 -23.610 -44.352 1.00 62.42  ? 387  LYS A CE  1 
ATOM   808  N  NZ  . LYS A 1 124 ? -14.543 -24.512 -45.048 1.00 70.66  ? 387  LYS A NZ  1 
ATOM   809  N  N   . LYS A 1 125 ? -21.560 -25.660 -41.289 1.00 47.45  ? 388  LYS A N   1 
ATOM   810  C  CA  . LYS A 1 125 ? -22.746 -26.527 -41.472 1.00 43.12  ? 388  LYS A CA  1 
ATOM   811  C  C   . LYS A 1 125 ? -23.596 -26.525 -40.194 1.00 41.22  ? 388  LYS A C   1 
ATOM   812  O  O   . LYS A 1 125 ? -24.366 -27.439 -40.010 1.00 48.09  ? 388  LYS A O   1 
ATOM   813  C  CB  . LYS A 1 125 ? -22.273 -27.924 -41.849 1.00 50.10  ? 388  LYS A CB  1 
ATOM   814  C  CG  . LYS A 1 125 ? -21.603 -28.018 -43.209 1.00 56.27  ? 388  LYS A CG  1 
ATOM   815  C  CD  . LYS A 1 125 ? -21.157 -29.442 -43.519 1.00 69.13  ? 388  LYS A CD  1 
ATOM   816  C  CE  . LYS A 1 125 ? -20.004 -29.917 -42.650 1.00 80.13  ? 388  LYS A CE  1 
ATOM   817  N  NZ  . LYS A 1 125 ? -20.156 -31.339 -42.242 1.00 87.46  ? 388  LYS A NZ  1 
ATOM   818  N  N   . LYS A 1 126 ? -23.430 -25.541 -39.314 1.00 41.84  ? 389  LYS A N   1 
ATOM   819  C  CA  . LYS A 1 126 ? -24.195 -25.467 -38.053 1.00 43.20  ? 389  LYS A CA  1 
ATOM   820  C  C   . LYS A 1 126 ? -24.660 -24.029 -37.877 1.00 42.39  ? 389  LYS A C   1 
ATOM   821  O  O   . LYS A 1 126 ? -24.046 -23.131 -38.448 1.00 47.44  ? 389  LYS A O   1 
ATOM   822  C  CB  . LYS A 1 126 ? -23.389 -25.898 -36.825 1.00 40.43  ? 389  LYS A CB  1 
ATOM   823  C  CG  . LYS A 1 126 ? -22.812 -27.299 -36.899 1.00 39.31  ? 389  LYS A CG  1 
ATOM   824  C  CD  . LYS A 1 126 ? -23.774 -28.356 -36.460 1.00 41.63  ? 389  LYS A CD  1 
ATOM   825  C  CE  . LYS A 1 126 ? -23.144 -29.719 -36.484 1.00 40.58  ? 389  LYS A CE  1 
ATOM   826  N  NZ  . LYS A 1 126 ? -24.151 -30.775 -36.335 1.00 39.41  ? 389  LYS A NZ  1 
ATOM   827  N  N   . THR A 1 127 ? -25.740 -23.860 -37.116 1.00 46.14  ? 390  THR A N   1 
ATOM   828  C  CA  . THR A 1 127 ? -26.370 -22.558 -36.827 1.00 44.63  ? 390  THR A CA  1 
ATOM   829  C  C   . THR A 1 127 ? -26.442 -22.406 -35.325 1.00 38.61  ? 390  THR A C   1 
ATOM   830  O  O   . THR A 1 127 ? -27.236 -23.061 -34.687 1.00 40.74  ? 390  THR A O   1 
ATOM   831  C  CB  . THR A 1 127 ? -27.795 -22.474 -37.404 1.00 49.20  ? 390  THR A CB  1 
ATOM   832  O  OG1 . THR A 1 127 ? -27.749 -22.645 -38.817 1.00 43.51  ? 390  THR A OG1 1 
ATOM   833  C  CG2 . THR A 1 127 ? -28.451 -21.156 -37.078 1.00 48.14  ? 390  THR A CG2 1 
ATOM   834  N  N   . PRO A 1 128 ? -25.686 -21.480 -34.717 1.00 38.11  ? 391  PRO A N   1 
ATOM   835  C  CA  . PRO A 1 128 ? -25.861 -21.232 -33.297 1.00 34.57  ? 391  PRO A CA  1 
ATOM   836  C  C   . PRO A 1 128 ? -27.341 -20.908 -33.014 1.00 42.35  ? 391  PRO A C   1 
ATOM   837  O  O   . PRO A 1 128 ? -28.011 -20.230 -33.824 1.00 42.97  ? 391  PRO A O   1 
ATOM   838  C  CB  . PRO A 1 128 ? -24.949 -20.045 -33.011 1.00 32.56  ? 391  PRO A CB  1 
ATOM   839  C  CG  . PRO A 1 128 ? -23.982 -20.044 -34.149 1.00 36.58  ? 391  PRO A CG  1 
ATOM   840  C  CD  . PRO A 1 128 ? -24.688 -20.622 -35.354 1.00 34.58  ? 391  PRO A CD  1 
ATOM   841  N  N   . ARG A 1 129 ? -27.840 -21.395 -31.882 1.00 42.09  ? 392  ARG A N   1 
ATOM   842  C  CA  . ARG A 1 129 ? -29.248 -21.165 -31.483 1.00 42.82  ? 392  ARG A CA  1 
ATOM   843  C  C   . ARG A 1 129 ? -29.390 -21.337 -29.973 1.00 47.83  ? 392  ARG A C   1 
ATOM   844  O  O   . ARG A 1 129 ? -28.557 -22.039 -29.314 1.00 40.45  ? 392  ARG A O   1 
ATOM   845  C  CB  . ARG A 1 129 ? -30.179 -22.043 -32.312 1.00 40.84  ? 392  ARG A CB  1 
ATOM   846  C  CG  . ARG A 1 129 ? -29.945 -23.533 -32.188 1.00 44.16  ? 392  ARG A CG  1 
ATOM   847  C  CD  . ARG A 1 129 ? -30.736 -24.098 -31.059 1.00 42.24  ? 392  ARG A CD  1 
ATOM   848  N  NE  . ARG A 1 129 ? -30.569 -25.528 -30.935 1.00 43.90  ? 392  ARG A NE  1 
ATOM   849  C  CZ  . ARG A 1 129 ? -31.121 -26.251 -29.973 1.00 45.38  ? 392  ARG A CZ  1 
ATOM   850  N  NH1 . ARG A 1 129 ? -31.953 -25.689 -29.110 1.00 45.31  ? 392  ARG A NH1 1 
ATOM   851  N  NH2 . ARG A 1 129 ? -30.909 -27.548 -29.929 1.00 42.81  ? 392  ARG A NH2 1 
ATOM   852  N  N   . MET A 1 130 ? -30.405 -20.679 -29.408 0.50 45.95  ? 393  MET A N   1 
ATOM   853  C  CA  . MET A 1 130 ? -30.715 -20.737 -27.960 0.50 46.42  ? 393  MET A CA  1 
ATOM   854  C  C   . MET A 1 130 ? -31.306 -22.115 -27.658 0.50 43.86  ? 393  MET A C   1 
ATOM   855  O  O   . MET A 1 130 ? -32.007 -22.654 -28.528 0.50 45.04  ? 393  MET A O   1 
ATOM   856  C  CB  . MET A 1 130 ? -31.711 -19.647 -27.555 0.50 52.09  ? 393  MET A CB  1 
ATOM   857  C  CG  . MET A 1 130 ? -31.147 -18.242 -27.648 0.50 55.62  ? 393  MET A CG  1 
ATOM   858  S  SD  . MET A 1 130 ? -31.749 -17.165 -26.316 0.50 59.04  ? 393  MET A SD  1 
ATOM   859  C  CE  . MET A 1 130 ? -33.468 -17.669 -26.244 0.50 59.13  ? 393  MET A CE  1 
ATOM   860  N  N   . CYS A 1 131 ? -30.991 -22.677 -26.492 1.00 41.70  ? 394  CYS A N   1 
ATOM   861  C  CA  . CYS A 1 131 ? -31.642 -23.909 -25.997 1.00 42.76  ? 394  CYS A CA  1 
ATOM   862  C  C   . CYS A 1 131 ? -32.823 -23.441 -25.135 1.00 45.88  ? 394  CYS A C   1 
ATOM   863  O  O   . CYS A 1 131 ? -32.818 -22.234 -24.737 1.00 50.84  ? 394  CYS A O   1 
ATOM   864  C  CB  . CYS A 1 131 ? -30.639 -24.800 -25.285 1.00 47.59  ? 394  CYS A CB  1 
ATOM   865  S  SG  . CYS A 1 131 ? -29.536 -25.637 -26.448 1.00 45.75  ? 394  CYS A SG  1 
ATOM   866  N  N   . THR A 1 132 ? -33.835 -24.284 -24.918 1.00 48.92  ? 395  THR A N   1 
ATOM   867  C  CA  . THR A 1 132 ? -35.160 -23.808 -24.398 1.00 56.31  ? 395  THR A CA  1 
ATOM   868  C  C   . THR A 1 132 ? -35.475 -24.395 -23.032 1.00 55.79  ? 395  THR A C   1 
ATOM   869  O  O   . THR A 1 132 ? -34.969 -25.492 -22.705 1.00 47.78  ? 395  THR A O   1 
ATOM   870  C  CB  . THR A 1 132 ? -36.318 -24.193 -25.326 1.00 52.20  ? 395  THR A CB  1 
ATOM   871  O  OG1 . THR A 1 132 ? -36.329 -25.615 -25.471 1.00 53.30  ? 395  THR A OG1 1 
ATOM   872  C  CG2 . THR A 1 132 ? -36.202 -23.531 -26.682 1.00 50.91  ? 395  THR A CG2 1 
ATOM   873  N  N   . ARG A 1 133 ? -36.298 -23.673 -22.262 0.50 61.32  ? 396  ARG A N   1 
ATOM   874  C  CA  . ARG A 1 133 ? -36.844 -24.099 -20.945 0.50 65.48  ? 396  ARG A CA  1 
ATOM   875  C  C   . ARG A 1 133 ? -37.461 -25.491 -21.104 0.50 65.19  ? 396  ARG A C   1 
ATOM   876  O  O   . ARG A 1 133 ? -37.286 -26.326 -20.202 0.50 67.41  ? 396  ARG A O   1 
ATOM   877  C  CB  . ARG A 1 133 ? -37.866 -23.075 -20.440 0.50 70.82  ? 396  ARG A CB  1 
ATOM   878  C  CG  . ARG A 1 133 ? -37.430 -21.628 -20.634 0.50 77.35  ? 396  ARG A CG  1 
ATOM   879  C  CD  . ARG A 1 133 ? -38.185 -20.640 -19.763 0.50 81.25  ? 396  ARG A CD  1 
ATOM   880  N  NE  . ARG A 1 133 ? -37.524 -19.342 -19.700 0.50 83.03  ? 396  ARG A NE  1 
ATOM   881  C  CZ  . ARG A 1 133 ? -37.877 -18.358 -18.878 0.50 89.77  ? 396  ARG A CZ  1 
ATOM   882  N  NH1 . ARG A 1 133 ? -38.894 -18.523 -18.047 0.50 89.88  ? 396  ARG A NH1 1 
ATOM   883  N  NH2 . ARG A 1 133 ? -37.214 -17.214 -18.888 0.50 89.86  ? 396  ARG A NH2 1 
ATOM   884  N  N   . GLU A 1 134 ? -38.130 -25.726 -22.235 0.50 65.68  ? 397  GLU A N   1 
ATOM   885  C  CA  . GLU A 1 134 ? -38.718 -27.038 -22.601 0.50 65.43  ? 397  GLU A CA  1 
ATOM   886  C  C   . GLU A 1 134 ? -37.596 -28.079 -22.665 0.50 63.74  ? 397  GLU A C   1 
ATOM   887  O  O   . GLU A 1 134 ? -37.686 -29.071 -21.921 0.50 63.52  ? 397  GLU A O   1 
ATOM   888  C  CB  . GLU A 1 134 ? -39.478 -26.919 -23.923 0.50 71.33  ? 397  GLU A CB  1 
ATOM   889  C  CG  . GLU A 1 134 ? -40.666 -25.974 -23.844 0.50 74.82  ? 397  GLU A CG  1 
ATOM   890  C  CD  . GLU A 1 134 ? -40.346 -24.582 -23.321 0.50 75.42  ? 397  GLU A CD  1 
ATOM   891  O  OE1 . GLU A 1 134 ? -39.642 -23.826 -24.027 0.50 71.22  ? 397  GLU A OE1 1 
ATOM   892  O  OE2 . GLU A 1 134 ? -40.800 -24.256 -22.203 0.50 77.65  ? 397  GLU A OE2 1 
ATOM   893  N  N   . GLU A 1 135 ? -36.575 -27.846 -23.502 1.00 62.56  ? 398  GLU A N   1 
ATOM   894  C  CA  . GLU A 1 135 ? -35.423 -28.785 -23.652 1.00 59.38  ? 398  GLU A CA  1 
ATOM   895  C  C   . GLU A 1 135 ? -34.792 -29.027 -22.277 1.00 59.29  ? 398  GLU A C   1 
ATOM   896  O  O   . GLU A 1 135 ? -34.525 -30.192 -21.959 1.00 58.69  ? 398  GLU A O   1 
ATOM   897  C  CB  . GLU A 1 135 ? -34.298 -28.261 -24.545 1.00 60.26  ? 398  GLU A CB  1 
ATOM   898  C  CG  . GLU A 1 135 ? -34.460 -28.577 -26.013 1.00 61.62  ? 398  GLU A CG  1 
ATOM   899  C  CD  . GLU A 1 135 ? -33.494 -27.809 -26.904 1.00 55.53  ? 398  GLU A CD  1 
ATOM   900  O  OE1 . GLU A 1 135 ? -33.191 -26.657 -26.583 1.00 47.84  ? 398  GLU A OE1 1 
ATOM   901  O  OE2 . GLU A 1 135 ? -33.052 -28.373 -27.914 1.00 61.34  ? 398  GLU A OE2 1 
ATOM   902  N  N   . PHE A 1 136 ? -34.570 -27.958 -21.504 1.00 54.56  ? 399  PHE A N   1 
ATOM   903  C  CA  . PHE A 1 136 ? -33.943 -28.024 -20.160 1.00 60.08  ? 399  PHE A CA  1 
ATOM   904  C  C   . PHE A 1 136 ? -34.812 -28.850 -19.198 1.00 64.85  ? 399  PHE A C   1 
ATOM   905  O  O   . PHE A 1 136 ? -34.249 -29.686 -18.450 1.00 56.57  ? 399  PHE A O   1 
ATOM   906  C  CB  . PHE A 1 136 ? -33.695 -26.622 -19.607 1.00 56.74  ? 399  PHE A CB  1 
ATOM   907  C  CG  . PHE A 1 136 ? -32.936 -26.612 -18.305 1.00 61.49  ? 399  PHE A CG  1 
ATOM   908  C  CD1 . PHE A 1 136 ? -31.554 -26.582 -18.293 1.00 61.15  ? 399  PHE A CD1 1 
ATOM   909  C  CD2 . PHE A 1 136 ? -33.606 -26.616 -17.091 1.00 64.16  ? 399  PHE A CD2 1 
ATOM   910  C  CE1 . PHE A 1 136 ? -30.855 -26.535 -17.102 1.00 58.90  ? 399  PHE A CE1 1 
ATOM   911  C  CE2 . PHE A 1 136 ? -32.906 -26.569 -15.902 1.00 62.37  ? 399  PHE A CE2 1 
ATOM   912  C  CZ  . PHE A 1 136 ? -31.531 -26.532 -15.912 1.00 59.25  ? 399  PHE A CZ  1 
ATOM   913  N  N   . THR A 1 137 ? -36.132 -28.636 -19.213 1.00 63.23  ? 400  THR A N   1 
ATOM   914  C  CA  . THR A 1 137 ? -37.094 -29.341 -18.322 1.00 71.87  ? 400  THR A CA  1 
ATOM   915  C  C   . THR A 1 137 ? -37.065 -30.845 -18.612 1.00 73.66  ? 400  THR A C   1 
ATOM   916  O  O   . THR A 1 137 ? -36.915 -31.643 -17.689 1.00 64.47  ? 400  THR A O   1 
ATOM   917  C  CB  . THR A 1 137 ? -38.516 -28.781 -18.433 1.00 68.83  ? 400  THR A CB  1 
ATOM   918  O  OG1 . THR A 1 137 ? -38.530 -27.428 -17.969 1.00 66.90  ? 400  THR A OG1 1 
ATOM   919  C  CG2 . THR A 1 137 ? -39.506 -29.598 -17.636 1.00 67.25  ? 400  THR A CG2 1 
ATOM   920  N  N   . ARG A 1 138 ? -37.214 -31.219 -19.883 0.44 75.07  ? 401  ARG A N   1 
ATOM   921  C  CA  . ARG A 1 138 ? -37.228 -32.640 -20.313 0.44 80.08  ? 401  ARG A CA  1 
ATOM   922  C  C   . ARG A 1 138 ? -35.923 -33.310 -19.867 0.44 79.49  ? 401  ARG A C   1 
ATOM   923  O  O   . ARG A 1 138 ? -35.985 -34.461 -19.397 0.44 82.02  ? 401  ARG A O   1 
ATOM   924  C  CB  . ARG A 1 138 ? -37.423 -32.742 -21.827 0.44 85.32  ? 401  ARG A CB  1 
ATOM   925  C  CG  . ARG A 1 138 ? -37.474 -34.174 -22.340 0.44 91.24  ? 401  ARG A CG  1 
ATOM   926  C  CD  . ARG A 1 138 ? -38.116 -34.255 -23.709 0.44 94.67  ? 401  ARG A CD  1 
ATOM   927  N  NE  . ARG A 1 138 ? -37.608 -33.216 -24.591 0.44 98.66  ? 401  ARG A NE  1 
ATOM   928  C  CZ  . ARG A 1 138 ? -36.505 -33.327 -25.321 0.44 103.42 ? 401  ARG A CZ  1 
ATOM   929  N  NH1 . ARG A 1 138 ? -35.792 -34.439 -25.275 0.44 106.86 ? 401  ARG A NH1 1 
ATOM   930  N  NH2 . ARG A 1 138 ? -36.120 -32.325 -26.093 0.44 104.31 ? 401  ARG A NH2 1 
ATOM   931  N  N   . LYS A 1 139 ? -34.795 -32.603 -19.990 1.00 79.58  ? 402  LYS A N   1 
ATOM   932  C  CA  . LYS A 1 139 ? -33.451 -33.133 -19.628 1.00 79.07  ? 402  LYS A CA  1 
ATOM   933  C  C   . LYS A 1 139 ? -33.361 -33.439 -18.134 1.00 86.14  ? 402  LYS A C   1 
ATOM   934  O  O   . LYS A 1 139 ? -32.862 -34.530 -17.771 1.00 83.65  ? 402  LYS A O   1 
ATOM   935  C  CB  . LYS A 1 139 ? -32.335 -32.158 -20.026 1.00 72.50  ? 402  LYS A CB  1 
ATOM   936  C  CG  . LYS A 1 139 ? -32.021 -32.151 -21.518 1.00 77.54  ? 402  LYS A CG  1 
ATOM   937  C  CD  . LYS A 1 139 ? -30.940 -31.172 -21.934 1.00 79.55  ? 402  LYS A CD  1 
ATOM   938  C  CE  . LYS A 1 139 ? -29.535 -31.658 -21.639 1.00 77.74  ? 402  LYS A CE  1 
ATOM   939  N  NZ  . LYS A 1 139 ? -29.194 -32.844 -22.465 1.00 75.39  ? 402  LYS A NZ  1 
ATOM   940  N  N   . VAL A 1 140 ? -33.819 -32.508 -17.289 0.56 89.73  ? 403  VAL A N   1 
ATOM   941  C  CA  . VAL A 1 140 ? -33.767 -32.643 -15.801 0.56 93.13  ? 403  VAL A CA  1 
ATOM   942  C  C   . VAL A 1 140 ? -34.757 -33.734 -15.366 0.56 96.47  ? 403  VAL A C   1 
ATOM   943  O  O   . VAL A 1 140 ? -34.456 -34.434 -14.380 0.56 101.23 ? 403  VAL A O   1 
ATOM   944  C  CB  . VAL A 1 140 ? -34.023 -31.305 -15.074 0.56 93.23  ? 403  VAL A CB  1 
ATOM   945  C  CG1 . VAL A 1 140 ? -33.118 -30.200 -15.595 0.56 91.99  ? 403  VAL A CG1 1 
ATOM   946  C  CG2 . VAL A 1 140 ? -35.479 -30.872 -15.129 0.56 93.73  ? 403  VAL A CG2 1 
ATOM   947  N  N   . ARG A 1 141 ? -35.872 -33.891 -16.089 1.00 97.54  ? 404  ARG A N   1 
ATOM   948  C  CA  . ARG A 1 141 ? -36.907 -34.918 -15.772 1.00 96.10  ? 404  ARG A CA  1 
ATOM   949  C  C   . ARG A 1 141 ? -36.522 -36.318 -16.278 1.00 95.96  ? 404  ARG A C   1 
ATOM   950  O  O   . ARG A 1 141 ? -37.350 -37.233 -16.170 1.00 102.60 ? 404  ARG A O   1 
ATOM   951  C  CB  . ARG A 1 141 ? -38.267 -34.462 -16.302 1.00 93.60  ? 404  ARG A CB  1 
ATOM   952  C  CG  . ARG A 1 141 ? -38.891 -33.363 -15.452 1.00 97.30  ? 404  ARG A CG  1 
ATOM   953  C  CD  . ARG A 1 141 ? -40.368 -33.589 -15.195 1.00 109.14 ? 404  ARG A CD  1 
ATOM   954  N  NE  . ARG A 1 141 ? -41.154 -33.215 -16.361 1.00 112.63 ? 404  ARG A NE  1 
ATOM   955  C  CZ  . ARG A 1 141 ? -41.754 -32.043 -16.534 1.00 115.68 ? 404  ARG A CZ  1 
ATOM   956  N  NH1 . ARG A 1 141 ? -41.688 -31.104 -15.599 1.00 110.53 ? 404  ARG A NH1 1 
ATOM   957  N  NH2 . ARG A 1 141 ? -42.433 -31.819 -17.648 1.00 116.75 ? 404  ARG A NH2 1 
ATOM   958  N  N   . SER A 1 142 ? -35.299 -36.470 -16.803 0.44 97.38  ? 405  SER A N   1 
ATOM   959  C  CA  . SER A 1 142 ? -34.724 -37.751 -17.295 0.44 99.64  ? 405  SER A CA  1 
ATOM   960  C  C   . SER A 1 142 ? -33.274 -37.895 -16.817 0.44 99.31  ? 405  SER A C   1 
ATOM   961  O  O   . SER A 1 142 ? -32.554 -38.756 -17.361 0.44 101.07 ? 405  SER A O   1 
ATOM   962  C  CB  . SER A 1 142 ? -34.817 -37.835 -18.797 0.44 100.98 ? 405  SER A CB  1 
ATOM   963  O  OG  . SER A 1 142 ? -34.275 -36.671 -19.403 0.44 102.95 ? 405  SER A OG  1 
ATOM   964  N  N   . ASN A 1 143 ? -32.874 -37.080 -15.835 0.44 97.55  ? 406  ASN A N   1 
ATOM   965  C  CA  . ASN A 1 143 ? -31.498 -37.043 -15.270 0.44 96.04  ? 406  ASN A CA  1 
ATOM   966  C  C   . ASN A 1 143 ? -30.520 -36.592 -16.360 0.44 94.17  ? 406  ASN A C   1 
ATOM   967  O  O   . ASN A 1 143 ? -29.306 -36.672 -16.097 0.44 94.65  ? 406  ASN A O   1 
ATOM   968  C  CB  . ASN A 1 143 ? -31.084 -38.398 -14.689 0.44 97.32  ? 406  ASN A CB  1 
ATOM   969  C  CG  . ASN A 1 143 ? -31.839 -38.759 -13.427 0.44 97.22  ? 406  ASN A CG  1 
ATOM   970  O  OD1 . ASN A 1 143 ? -32.773 -38.064 -13.031 0.44 96.92  ? 406  ASN A OD1 1 
ATOM   971  N  ND2 . ASN A 1 143 ? -31.444 -39.848 -12.789 0.44 95.60  ? 406  ASN A ND2 1 
ATOM   972  N  N   . TRP A 1 156 ? -36.691 -25.623 -2.813  0.44 81.87  ? 419  TRP A N   1 
ATOM   973  C  CA  . TRP A 1 156 ? -37.010 -26.840 -3.606  0.44 82.89  ? 419  TRP A CA  1 
ATOM   974  C  C   . TRP A 1 156 ? -36.091 -27.989 -3.186  0.44 84.41  ? 419  TRP A C   1 
ATOM   975  O  O   . TRP A 1 156 ? -34.919 -27.721 -2.863  0.44 85.24  ? 419  TRP A O   1 
ATOM   976  C  CB  . TRP A 1 156 ? -36.881 -26.563 -5.109  0.44 81.60  ? 419  TRP A CB  1 
ATOM   977  C  CG  . TRP A 1 156 ? -37.734 -25.437 -5.603  0.44 77.90  ? 419  TRP A CG  1 
ATOM   978  C  CD1 . TRP A 1 156 ? -39.080 -25.458 -5.820  0.44 76.61  ? 419  TRP A CD1 1 
ATOM   979  C  CD2 . TRP A 1 156 ? -37.290 -24.116 -5.961  0.44 77.43  ? 419  TRP A CD2 1 
ATOM   980  N  NE1 . TRP A 1 156 ? -39.506 -24.241 -6.278  0.44 78.16  ? 419  TRP A NE1 1 
ATOM   981  C  CE2 . TRP A 1 156 ? -38.431 -23.398 -6.377  0.44 76.41  ? 419  TRP A CE2 1 
ATOM   982  C  CE3 . TRP A 1 156 ? -36.048 -23.473 -5.968  0.44 77.22  ? 419  TRP A CE3 1 
ATOM   983  C  CZ2 . TRP A 1 156 ? -38.361 -22.070 -6.794  0.44 78.17  ? 419  TRP A CZ2 1 
ATOM   984  C  CZ3 . TRP A 1 156 ? -35.981 -22.162 -6.381  0.44 77.62  ? 419  TRP A CZ3 1 
ATOM   985  C  CH2 . TRP A 1 156 ? -37.123 -21.472 -6.787  0.44 78.12  ? 419  TRP A CH2 1 
ATOM   986  N  N   . LYS A 1 157 ? -36.604 -29.221 -3.211  0.44 86.88  ? 420  LYS A N   1 
ATOM   987  C  CA  . LYS A 1 157 ? -35.767 -30.400 -2.875  0.44 88.71  ? 420  LYS A CA  1 
ATOM   988  C  C   . LYS A 1 157 ? -34.955 -30.780 -4.112  0.44 89.03  ? 420  LYS A C   1 
ATOM   989  O  O   . LYS A 1 157 ? -33.773 -30.395 -4.184  0.44 88.97  ? 420  LYS A O   1 
ATOM   990  C  CB  . LYS A 1 157 ? -36.652 -31.573 -2.451  0.44 90.71  ? 420  LYS A CB  1 
ATOM   991  C  CG  . LYS A 1 157 ? -35.930 -32.899 -2.264  0.44 91.91  ? 420  LYS A CG  1 
ATOM   992  C  CD  . LYS A 1 157 ? -36.825 -34.098 -2.488  0.44 91.60  ? 420  LYS A CD  1 
ATOM   993  C  CE  . LYS A 1 157 ? -38.065 -34.084 -1.619  0.44 90.08  ? 420  LYS A CE  1 
ATOM   994  N  NZ  . LYS A 1 157 ? -38.956 -35.229 -1.917  0.44 88.92  ? 420  LYS A NZ  1 
ATOM   995  N  N   . SER A 1 158 ? -35.584 -31.486 -5.052  0.44 86.66  ? 421  SER A N   1 
ATOM   996  C  CA  . SER A 1 158 ? -34.894 -31.895 -6.300  0.44 84.77  ? 421  SER A CA  1 
ATOM   997  C  C   . SER A 1 158 ? -35.023 -30.780 -7.339  0.44 84.91  ? 421  SER A C   1 
ATOM   998  O  O   . SER A 1 158 ? -35.811 -29.844 -7.107  0.44 84.58  ? 421  SER A O   1 
ATOM   999  C  CB  . SER A 1 158 ? -35.448 -33.194 -6.814  0.44 82.28  ? 421  SER A CB  1 
ATOM   1000 O  OG  . SER A 1 158 ? -36.841 -33.083 -7.062  0.44 83.95  ? 421  SER A OG  1 
ATOM   1001 N  N   . ALA A 1 159 ? -34.270 -30.878 -8.435  0.44 84.77  ? 422  ALA A N   1 
ATOM   1002 C  CA  . ALA A 1 159 ? -34.351 -29.871 -9.517  0.44 81.99  ? 422  ALA A CA  1 
ATOM   1003 C  C   . ALA A 1 159 ? -35.676 -30.033 -10.264 0.44 78.06  ? 422  ALA A C   1 
ATOM   1004 O  O   . ALA A 1 159 ? -36.182 -29.032 -10.797 0.44 74.36  ? 422  ALA A O   1 
ATOM   1005 C  CB  . ALA A 1 159 ? -33.175 -30.033 -10.442 0.44 82.98  ? 422  ALA A CB  1 
ATOM   1006 N  N   . ARG A 1 160 ? -36.212 -31.255 -10.292 0.44 78.03  ? 423  ARG A N   1 
ATOM   1007 C  CA  . ARG A 1 160 ? -37.491 -31.514 -11.002 0.44 80.22  ? 423  ARG A CA  1 
ATOM   1008 C  C   . ARG A 1 160 ? -38.589 -30.631 -10.399 0.44 82.10  ? 423  ARG A C   1 
ATOM   1009 O  O   . ARG A 1 160 ? -39.370 -30.049 -11.173 0.44 83.94  ? 423  ARG A O   1 
ATOM   1010 C  CB  . ARG A 1 160 ? -37.841 -33.003 -10.928 0.44 79.34  ? 423  ARG A CB  1 
ATOM   1011 C  CG  . ARG A 1 160 ? -36.865 -33.897 -11.679 0.44 81.22  ? 423  ARG A CG  1 
ATOM   1012 C  CD  . ARG A 1 160 ? -37.323 -35.338 -11.795 0.44 80.85  ? 423  ARG A CD  1 
ATOM   1013 N  NE  . ARG A 1 160 ? -36.401 -36.130 -12.597 0.44 80.24  ? 423  ARG A NE  1 
ATOM   1014 C  CZ  . ARG A 1 160 ? -36.570 -37.413 -12.893 0.44 81.63  ? 423  ARG A CZ  1 
ATOM   1015 N  NH1 . ARG A 1 160 ? -35.675 -38.047 -13.630 0.44 79.64  ? 423  ARG A NH1 1 
ATOM   1016 N  NH2 . ARG A 1 160 ? -37.636 -38.057 -12.452 0.44 82.89  ? 423  ARG A NH2 1 
ATOM   1017 N  N   . GLU A 1 161 ? -38.623 -30.515 -9.071  0.44 83.17  ? 424  GLU A N   1 
ATOM   1018 C  CA  . GLU A 1 161 ? -39.642 -29.669 -8.400  0.44 82.95  ? 424  GLU A CA  1 
ATOM   1019 C  C   . GLU A 1 161 ? -39.468 -28.220 -8.857  0.44 80.22  ? 424  GLU A C   1 
ATOM   1020 O  O   . GLU A 1 161 ? -40.478 -27.594 -9.224  0.44 81.56  ? 424  GLU A O   1 
ATOM   1021 C  CB  . GLU A 1 161 ? -39.493 -29.767 -6.882  0.44 86.47  ? 424  GLU A CB  1 
ATOM   1022 C  CG  . GLU A 1 161 ? -39.424 -31.194 -6.373  0.44 89.14  ? 424  GLU A CG  1 
ATOM   1023 C  CD  . GLU A 1 161 ? -39.164 -31.312 -4.882  0.44 90.39  ? 424  GLU A CD  1 
ATOM   1024 O  OE1 . GLU A 1 161 ? -39.007 -30.263 -4.226  0.44 89.58  ? 424  GLU A OE1 1 
ATOM   1025 O  OE2 . GLU A 1 161 ? -39.120 -32.452 -4.380  0.44 94.27  ? 424  GLU A OE2 1 
ATOM   1026 N  N   . ALA A 1 162 ? -38.231 -27.720 -8.848  0.34 75.90  ? 425  ALA A N   1 
ATOM   1027 C  CA  . ALA A 1 162 ? -37.972 -26.314 -9.234  0.34 76.32  ? 425  ALA A CA  1 
ATOM   1028 C  C   . ALA A 1 162 ? -38.392 -26.096 -10.688 0.34 75.48  ? 425  ALA A C   1 
ATOM   1029 O  O   . ALA A 1 162 ? -38.974 -25.036 -10.982 0.34 74.18  ? 425  ALA A O   1 
ATOM   1030 C  CB  . ALA A 1 162 ? -36.514 -25.991 -9.031  0.34 76.61  ? 425  ALA A CB  1 
ATOM   1031 N  N   . VAL A 1 163 ? -38.114 -27.069 -11.557 0.44 77.14  ? 426  VAL A N   1 
ATOM   1032 C  CA  . VAL A 1 163 ? -38.430 -26.925 -13.009 0.44 80.16  ? 426  VAL A CA  1 
ATOM   1033 C  C   . VAL A 1 163 ? -39.948 -26.829 -13.172 0.44 81.89  ? 426  VAL A C   1 
ATOM   1034 O  O   . VAL A 1 163 ? -40.399 -26.297 -14.202 0.44 82.73  ? 426  VAL A O   1 
ATOM   1035 C  CB  . VAL A 1 163 ? -37.844 -28.093 -13.825 0.44 79.80  ? 426  VAL A CB  1 
ATOM   1036 C  CG1 . VAL A 1 163 ? -38.872 -29.182 -14.082 0.44 79.27  ? 426  VAL A CG1 1 
ATOM   1037 C  CG2 . VAL A 1 163 ? -37.234 -27.612 -15.131 0.44 83.00  ? 426  VAL A CG2 1 
ATOM   1038 N  N   . GLU A 1 164 ? -40.699 -27.329 -12.189 0.44 84.37  ? 427  GLU A N   1 
ATOM   1039 C  CA  . GLU A 1 164 ? -42.183 -27.295 -12.256 0.44 86.08  ? 427  GLU A CA  1 
ATOM   1040 C  C   . GLU A 1 164 ? -42.706 -26.088 -11.469 0.44 86.04  ? 427  GLU A C   1 
ATOM   1041 O  O   . GLU A 1 164 ? -43.922 -25.837 -11.521 0.44 89.62  ? 427  GLU A O   1 
ATOM   1042 C  CB  . GLU A 1 164 ? -42.744 -28.612 -11.722 0.44 87.77  ? 427  GLU A CB  1 
ATOM   1043 C  CG  . GLU A 1 164 ? -42.215 -29.825 -12.464 0.44 90.18  ? 427  GLU A CG  1 
ATOM   1044 C  CD  . GLU A 1 164 ? -42.248 -31.118 -11.669 0.44 93.19  ? 427  GLU A CD  1 
ATOM   1045 O  OE1 . GLU A 1 164 ? -42.719 -31.087 -10.516 0.44 93.20  ? 427  GLU A OE1 1 
ATOM   1046 O  OE2 . GLU A 1 164 ? -41.796 -32.150 -12.203 0.44 93.68  ? 427  GLU A OE2 1 
ATOM   1047 N  N   . ASP A 1 165 ? -41.818 -25.366 -10.782 0.44 87.73  ? 428  ASP A N   1 
ATOM   1048 C  CA  . ASP A 1 165 ? -42.231 -24.188 -9.969  0.44 88.01  ? 428  ASP A CA  1 
ATOM   1049 C  C   . ASP A 1 165 ? -41.989 -22.905 -10.767 0.44 86.98  ? 428  ASP A C   1 
ATOM   1050 O  O   . ASP A 1 165 ? -40.845 -22.693 -11.205 0.44 83.01  ? 428  ASP A O   1 
ATOM   1051 C  CB  . ASP A 1 165 ? -41.517 -24.162 -8.616  0.44 88.02  ? 428  ASP A CB  1 
ATOM   1052 C  CG  . ASP A 1 165 ? -41.809 -22.911 -7.806  0.44 87.87  ? 428  ASP A CG  1 
ATOM   1053 O  OD1 . ASP A 1 165 ? -41.331 -21.833 -8.203  0.44 88.32  ? 428  ASP A OD1 1 
ATOM   1054 O  OD2 . ASP A 1 165 ? -42.511 -23.028 -6.784  0.44 88.14  ? 428  ASP A OD2 1 
ATOM   1055 N  N   . SER A 1 166 ? -43.022 -22.076 -10.920 0.56 88.21  ? 429  SER A N   1 
ATOM   1056 C  CA  . SER A 1 166 ? -42.911 -20.847 -11.747 0.56 89.07  ? 429  SER A CA  1 
ATOM   1057 C  C   . SER A 1 166 ? -42.049 -19.787 -11.052 0.56 89.24  ? 429  SER A C   1 
ATOM   1058 O  O   . SER A 1 166 ? -41.468 -18.951 -11.764 0.56 94.00  ? 429  SER A O   1 
ATOM   1059 C  CB  . SER A 1 166 ? -44.278 -20.315 -12.069 0.56 92.58  ? 429  SER A CB  1 
ATOM   1060 O  OG  . SER A 1 166 ? -45.036 -21.285 -12.776 0.56 96.48  ? 429  SER A OG  1 
ATOM   1061 N  N   . GLY A 1 167 ? -41.979 -19.816 -9.720  0.50 85.67  ? 430  GLY A N   1 
ATOM   1062 C  CA  . GLY A 1 167 ? -41.133 -18.854 -8.988  0.50 82.94  ? 430  GLY A CA  1 
ATOM   1063 C  C   . GLY A 1 167 ? -39.689 -18.958 -9.436  0.50 80.41  ? 430  GLY A C   1 
ATOM   1064 O  O   . GLY A 1 167 ? -39.044 -17.911 -9.582  0.50 77.94  ? 430  GLY A O   1 
ATOM   1065 N  N   . PHE A 1 168 ? -39.209 -20.183 -9.657  0.50 82.57  ? 431  PHE A N   1 
ATOM   1066 C  CA  . PHE A 1 168 ? -37.820 -20.405 -10.132 0.50 83.14  ? 431  PHE A CA  1 
ATOM   1067 C  C   . PHE A 1 168 ? -37.623 -19.695 -11.470 0.50 79.08  ? 431  PHE A C   1 
ATOM   1068 O  O   . PHE A 1 168 ? -36.646 -18.942 -11.613 0.50 77.46  ? 431  PHE A O   1 
ATOM   1069 C  CB  . PHE A 1 168 ? -37.560 -21.906 -10.272 0.50 86.79  ? 431  PHE A CB  1 
ATOM   1070 C  CG  . PHE A 1 168 ? -36.354 -22.283 -11.093 0.50 86.17  ? 431  PHE A CG  1 
ATOM   1071 C  CD1 . PHE A 1 168 ? -35.112 -22.435 -10.500 0.50 85.83  ? 431  PHE A CD1 1 
ATOM   1072 C  CD2 . PHE A 1 168 ? -36.465 -22.503 -12.456 0.50 88.18  ? 431  PHE A CD2 1 
ATOM   1073 C  CE1 . PHE A 1 168 ? -34.005 -22.788 -11.255 0.50 87.94  ? 431  PHE A CE1 1 
ATOM   1074 C  CE2 . PHE A 1 168 ? -35.358 -22.855 -13.210 0.50 88.47  ? 431  PHE A CE2 1 
ATOM   1075 C  CZ  . PHE A 1 168 ? -34.130 -22.998 -12.608 0.50 89.44  ? 431  PHE A CZ  1 
ATOM   1076 N  N   . TRP A 1 169 ? -38.538 -19.925 -12.412 0.50 76.35  ? 432  TRP A N   1 
ATOM   1077 C  CA  . TRP A 1 169 ? -38.422 -19.305 -13.755 0.50 75.47  ? 432  TRP A CA  1 
ATOM   1078 C  C   . TRP A 1 169 ? -38.523 -17.784 -13.617 0.50 78.69  ? 432  TRP A C   1 
ATOM   1079 O  O   . TRP A 1 169 ? -37.965 -17.073 -14.471 0.50 80.92  ? 432  TRP A O   1 
ATOM   1080 C  CB  . TRP A 1 169 ? -39.469 -19.896 -14.703 0.50 72.27  ? 432  TRP A CB  1 
ATOM   1081 C  CG  . TRP A 1 169 ? -39.273 -21.363 -14.924 0.50 74.08  ? 432  TRP A CG  1 
ATOM   1082 C  CD1 . TRP A 1 169 ? -40.052 -22.380 -14.455 0.50 75.51  ? 432  TRP A CD1 1 
ATOM   1083 C  CD2 . TRP A 1 169 ? -38.198 -21.984 -15.650 0.50 75.14  ? 432  TRP A CD2 1 
ATOM   1084 N  NE1 . TRP A 1 169 ? -39.546 -23.588 -14.852 0.50 76.32  ? 432  TRP A NE1 1 
ATOM   1085 C  CE2 . TRP A 1 169 ? -38.409 -23.377 -15.586 0.50 74.60  ? 432  TRP A CE2 1 
ATOM   1086 C  CE3 . TRP A 1 169 ? -37.088 -21.502 -16.352 0.50 75.18  ? 432  TRP A CE3 1 
ATOM   1087 C  CZ2 . TRP A 1 169 ? -37.549 -24.287 -16.198 0.50 74.92  ? 432  TRP A CZ2 1 
ATOM   1088 C  CZ3 . TRP A 1 169 ? -36.240 -22.403 -16.956 0.50 74.64  ? 432  TRP A CZ3 1 
ATOM   1089 C  CH2 . TRP A 1 169 ? -36.469 -23.776 -16.878 0.50 74.37  ? 432  TRP A CH2 1 
ATOM   1090 N  N   . GLU A 1 170 ? -39.200 -17.306 -12.574 0.50 83.80  ? 433  GLU A N   1 
ATOM   1091 C  CA  . GLU A 1 170 ? -39.262 -15.843 -12.325 0.50 86.99  ? 433  GLU A CA  1 
ATOM   1092 C  C   . GLU A 1 170 ? -37.889 -15.378 -11.837 0.50 81.91  ? 433  GLU A C   1 
ATOM   1093 O  O   . GLU A 1 170 ? -37.431 -14.319 -12.296 0.50 84.09  ? 433  GLU A O   1 
ATOM   1094 C  CB  . GLU A 1 170 ? -40.373 -15.526 -11.323 0.50 92.25  ? 433  GLU A CB  1 
ATOM   1095 C  CG  . GLU A 1 170 ? -41.763 -15.695 -11.906 0.50 97.76  ? 433  GLU A CG  1 
ATOM   1096 C  CD  . GLU A 1 170 ? -42.901 -15.290 -10.985 0.50 102.92 ? 433  GLU A CD  1 
ATOM   1097 O  OE1 . GLU A 1 170 ? -43.987 -14.964 -11.500 0.50 103.01 ? 433  GLU A OE1 1 
ATOM   1098 O  OE2 . GLU A 1 170 ? -42.699 -15.307 -9.755  0.50 108.67 ? 433  GLU A OE2 1 
ATOM   1099 N  N   . LEU A 1 171 ? -37.261 -16.146 -10.947 0.50 77.61  ? 434  LEU A N   1 
ATOM   1100 C  CA  . LEU A 1 171 ? -35.893 -15.807 -10.483 0.50 78.31  ? 434  LEU A CA  1 
ATOM   1101 C  C   . LEU A 1 171 ? -34.968 -15.799 -11.701 0.50 76.67  ? 434  LEU A C   1 
ATOM   1102 O  O   . LEU A 1 171 ? -34.139 -14.880 -11.806 0.50 73.24  ? 434  LEU A O   1 
ATOM   1103 C  CB  . LEU A 1 171 ? -35.454 -16.873 -9.477  0.50 78.32  ? 434  LEU A CB  1 
ATOM   1104 C  CG  . LEU A 1 171 ? -36.376 -17.075 -8.277  0.50 81.03  ? 434  LEU A CG  1 
ATOM   1105 C  CD1 . LEU A 1 171 ? -35.915 -18.254 -7.436  0.50 82.27  ? 434  LEU A CD1 1 
ATOM   1106 C  CD2 . LEU A 1 171 ? -36.446 -15.814 -7.432  0.50 83.07  ? 434  LEU A CD2 1 
ATOM   1107 N  N   . VAL A 1 172 ? -35.119 -16.785 -12.583 0.50 74.29  ? 435  VAL A N   1 
ATOM   1108 C  CA  . VAL A 1 172 ? -34.280 -16.907 -13.810 0.50 71.39  ? 435  VAL A CA  1 
ATOM   1109 C  C   . VAL A 1 172 ? -34.432 -15.631 -14.640 0.50 70.17  ? 435  VAL A C   1 
ATOM   1110 O  O   . VAL A 1 172 ? -33.396 -15.032 -14.998 0.50 64.17  ? 435  VAL A O   1 
ATOM   1111 C  CB  . VAL A 1 172 ? -34.663 -18.151 -14.631 0.50 74.50  ? 435  VAL A CB  1 
ATOM   1112 C  CG1 . VAL A 1 172 ? -33.879 -18.222 -15.932 0.50 75.58  ? 435  VAL A CG1 1 
ATOM   1113 C  CG2 . VAL A 1 172 ? -34.494 -19.431 -13.826 0.50 76.80  ? 435  VAL A CG2 1 
ATOM   1114 N  N   . ASP A 1 173 ? -35.678 -15.237 -14.927 0.50 72.61  ? 436  ASP A N   1 
ATOM   1115 C  CA  . ASP A 1 173 ? -36.003 -14.064 -15.783 0.50 71.93  ? 436  ASP A CA  1 
ATOM   1116 C  C   . ASP A 1 173 ? -35.303 -12.823 -15.223 0.50 70.12  ? 436  ASP A C   1 
ATOM   1117 O  O   . ASP A 1 173 ? -34.756 -12.036 -16.025 0.50 68.92  ? 436  ASP A O   1 
ATOM   1118 C  CB  . ASP A 1 173 ? -37.514 -13.862 -15.909 0.50 76.48  ? 436  ASP A CB  1 
ATOM   1119 C  CG  . ASP A 1 173 ? -38.096 -14.533 -17.141 0.50 79.57  ? 436  ASP A CG  1 
ATOM   1120 O  OD1 . ASP A 1 173 ? -37.689 -14.148 -18.261 0.50 82.47  ? 436  ASP A OD1 1 
ATOM   1121 O  OD2 . ASP A 1 173 ? -38.932 -15.446 -16.972 0.50 84.83  ? 436  ASP A OD2 1 
ATOM   1122 N  N   . LYS A 1 174 ? -35.312 -12.658 -13.898 0.50 67.65  ? 437  LYS A N   1 
ATOM   1123 C  CA  . LYS A 1 174 ? -34.679 -11.497 -13.221 0.50 68.90  ? 437  LYS A CA  1 
ATOM   1124 C  C   . LYS A 1 174 ? -33.196 -11.462 -13.608 0.50 68.43  ? 437  LYS A C   1 
ATOM   1125 O  O   . LYS A 1 174 ? -32.764 -10.445 -14.205 0.50 63.68  ? 437  LYS A O   1 
ATOM   1126 C  CB  . LYS A 1 174 ? -34.874 -11.578 -11.703 0.50 70.54  ? 437  LYS A CB  1 
ATOM   1127 C  CG  . LYS A 1 174 ? -34.275 -10.418 -10.920 0.50 74.66  ? 437  LYS A CG  1 
ATOM   1128 C  CD  . LYS A 1 174 ? -34.455 -10.544 -9.421  0.50 78.77  ? 437  LYS A CD  1 
ATOM   1129 C  CE  . LYS A 1 174 ? -33.801 -9.419  -8.647  0.50 80.33  ? 437  LYS A CE  1 
ATOM   1130 N  NZ  . LYS A 1 174 ? -33.901 -9.642  -7.186  0.50 83.24  ? 437  LYS A NZ  1 
ATOM   1131 N  N   . GLU A 1 175 ? -32.455 -12.536 -13.298 0.50 67.40  ? 438  GLU A N   1 
ATOM   1132 C  CA  . GLU A 1 175 ? -31.004 -12.666 -13.607 0.50 65.57  ? 438  GLU A CA  1 
ATOM   1133 C  C   . GLU A 1 175 ? -30.796 -12.445 -15.108 0.50 62.26  ? 438  GLU A C   1 
ATOM   1134 O  O   . GLU A 1 175 ? -29.885 -11.672 -15.470 0.50 62.44  ? 438  GLU A O   1 
ATOM   1135 C  CB  . GLU A 1 175 ? -30.466 -14.027 -13.162 0.50 67.39  ? 438  GLU A CB  1 
ATOM   1136 C  CG  . GLU A 1 175 ? -29.703 -13.981 -11.848 0.50 69.79  ? 438  GLU A CG  1 
ATOM   1137 C  CD  . GLU A 1 175 ? -28.274 -13.478 -11.955 0.50 70.84  ? 438  GLU A CD  1 
ATOM   1138 O  OE1 . GLU A 1 175 ? -27.350 -14.323 -11.902 0.50 75.50  ? 438  GLU A OE1 1 
ATOM   1139 O  OE2 . GLU A 1 175 ? -28.084 -12.247 -12.076 0.50 68.91  ? 438  GLU A OE2 1 
ATOM   1140 N  N   . ARG A 1 176 ? -31.626 -13.081 -15.943 0.50 61.96  ? 439  ARG A N   1 
ATOM   1141 C  CA  . ARG A 1 176 ? -31.549 -12.976 -17.424 0.50 63.93  ? 439  ARG A CA  1 
ATOM   1142 C  C   . ARG A 1 176 ? -31.519 -11.491 -17.806 0.50 66.53  ? 439  ARG A C   1 
ATOM   1143 O  O   . ARG A 1 176 ? -30.500 -11.046 -18.381 0.50 62.56  ? 439  ARG A O   1 
ATOM   1144 C  CB  . ARG A 1 176 ? -32.711 -13.733 -18.073 0.50 67.93  ? 439  ARG A CB  1 
ATOM   1145 C  CG  . ARG A 1 176 ? -32.628 -13.836 -19.590 0.50 69.92  ? 439  ARG A CG  1 
ATOM   1146 C  CD  . ARG A 1 176 ? -33.523 -14.948 -20.112 0.50 73.16  ? 439  ARG A CD  1 
ATOM   1147 N  NE  . ARG A 1 176 ? -33.702 -14.896 -21.556 0.50 80.20  ? 439  ARG A NE  1 
ATOM   1148 C  CZ  . ARG A 1 176 ? -34.382 -15.795 -22.261 0.50 87.12  ? 439  ARG A CZ  1 
ATOM   1149 N  NH1 . ARG A 1 176 ? -34.946 -16.823 -21.645 0.50 90.27  ? 439  ARG A NH1 1 
ATOM   1150 N  NH2 . ARG A 1 176 ? -34.496 -15.662 -23.574 0.50 82.12  ? 439  ARG A NH2 1 
ATOM   1151 N  N   . ASN A 1 177 ? -32.575 -10.744 -17.466 0.50 70.11  ? 440  ASN A N   1 
ATOM   1152 C  CA  . ASN A 1 177 ? -32.693 -9.289  -17.761 0.50 72.37  ? 440  ASN A CA  1 
ATOM   1153 C  C   . ASN A 1 177 ? -31.456 -8.567  -17.212 0.50 70.86  ? 440  ASN A C   1 
ATOM   1154 O  O   . ASN A 1 177 ? -30.960 -7.644  -17.891 0.50 72.60  ? 440  ASN A O   1 
ATOM   1155 C  CB  . ASN A 1 177 ? -34.004 -8.710  -17.223 0.50 75.97  ? 440  ASN A CB  1 
ATOM   1156 C  CG  . ASN A 1 177 ? -35.212 -9.208  -17.989 0.50 79.19  ? 440  ASN A CG  1 
ATOM   1157 O  OD1 . ASN A 1 177 ? -35.121 -9.506  -19.180 0.50 79.90  ? 440  ASN A OD1 1 
ATOM   1158 N  ND2 . ASN A 1 177 ? -36.347 -9.304  -17.315 0.50 79.67  ? 440  ASN A ND2 1 
ATOM   1159 N  N   . LEU A 1 178 ? -30.968 -8.981  -16.039 0.50 68.14  ? 441  LEU A N   1 
ATOM   1160 C  CA  . LEU A 1 178 ? -29.698 -8.481  -15.450 0.50 70.78  ? 441  LEU A CA  1 
ATOM   1161 C  C   . LEU A 1 178 ? -28.558 -8.700  -16.453 0.50 70.21  ? 441  LEU A C   1 
ATOM   1162 O  O   . LEU A 1 178 ? -27.858 -7.719  -16.777 0.50 66.78  ? 441  LEU A O   1 
ATOM   1163 C  CB  . LEU A 1 178 ? -29.435 -9.208  -14.128 0.50 74.27  ? 441  LEU A CB  1 
ATOM   1164 C  CG  . LEU A 1 178 ? -30.269 -8.719  -12.944 0.50 77.24  ? 441  LEU A CG  1 
ATOM   1165 C  CD1 . LEU A 1 178 ? -30.057 -9.597  -11.718 0.50 78.83  ? 441  LEU A CD1 1 
ATOM   1166 C  CD2 . LEU A 1 178 ? -29.948 -7.267  -12.624 0.50 78.85  ? 441  LEU A CD2 1 
ATOM   1167 N  N   . HIS A 1 179 ? -28.398 -9.936  -16.938 0.50 67.80  ? 442  HIS A N   1 
ATOM   1168 C  CA  . HIS A 1 179 ? -27.351 -10.332 -17.920 0.50 66.94  ? 442  HIS A CA  1 
ATOM   1169 C  C   . HIS A 1 179 ? -27.467 -9.455  -19.172 0.50 67.69  ? 442  HIS A C   1 
ATOM   1170 O  O   . HIS A 1 179 ? -26.414 -9.048  -19.707 0.50 66.68  ? 442  HIS A O   1 
ATOM   1171 C  CB  . HIS A 1 179 ? -27.455 -11.830 -18.246 0.50 64.86  ? 442  HIS A CB  1 
ATOM   1172 C  CG  . HIS A 1 179 ? -26.922 -12.726 -17.176 0.50 63.64  ? 442  HIS A CG  1 
ATOM   1173 N  ND1 . HIS A 1 179 ? -26.739 -14.084 -17.371 0.50 63.36  ? 442  HIS A ND1 1 
ATOM   1174 C  CD2 . HIS A 1 179 ? -26.520 -12.470 -15.911 0.50 60.10  ? 442  HIS A CD2 1 
ATOM   1175 C  CE1 . HIS A 1 179 ? -26.262 -14.622 -16.268 0.50 62.37  ? 442  HIS A CE1 1 
ATOM   1176 N  NE2 . HIS A 1 179 ? -26.111 -13.652 -15.361 0.50 58.72  ? 442  HIS A NE2 1 
ATOM   1177 N  N   . LEU A 1 180 ? -28.696 -9.168  -19.613 0.50 70.68  ? 443  LEU A N   1 
ATOM   1178 C  CA  . LEU A 1 180 ? -28.979 -8.317  -20.801 0.50 70.37  ? 443  LEU A CA  1 
ATOM   1179 C  C   . LEU A 1 180 ? -28.435 -6.908  -20.540 0.50 71.52  ? 443  LEU A C   1 
ATOM   1180 O  O   . LEU A 1 180 ? -28.098 -6.224  -21.517 0.50 74.69  ? 443  LEU A O   1 
ATOM   1181 C  CB  . LEU A 1 180 ? -30.487 -8.307  -21.081 0.50 70.31  ? 443  LEU A CB  1 
ATOM   1182 C  CG  . LEU A 1 180 ? -31.094 -9.653  -21.488 0.50 70.81  ? 443  LEU A CG  1 
ATOM   1183 C  CD1 . LEU A 1 180 ? -32.606 -9.649  -21.322 0.50 70.60  ? 443  LEU A CD1 1 
ATOM   1184 C  CD2 . LEU A 1 180 ? -30.725 -10.021 -22.917 0.50 69.54  ? 443  LEU A CD2 1 
ATOM   1185 N  N   . GLU A 1 181 ? -28.327 -6.512  -19.267 0.56 76.34  ? 444  GLU A N   1 
ATOM   1186 C  CA  . GLU A 1 181 ? -27.759 -5.203  -18.836 0.56 85.22  ? 444  GLU A CA  1 
ATOM   1187 C  C   . GLU A 1 181 ? -26.230 -5.294  -18.726 0.56 84.60  ? 444  GLU A C   1 
ATOM   1188 O  O   . GLU A 1 181 ? -25.573 -4.232  -18.771 0.56 86.08  ? 444  GLU A O   1 
ATOM   1189 C  CB  . GLU A 1 181 ? -28.332 -4.769  -17.484 0.56 91.23  ? 444  GLU A CB  1 
ATOM   1190 C  CG  . GLU A 1 181 ? -29.742 -4.207  -17.552 0.56 96.83  ? 444  GLU A CG  1 
ATOM   1191 C  CD  . GLU A 1 181 ? -30.253 -3.647  -16.233 0.56 102.66 ? 444  GLU A CD  1 
ATOM   1192 O  OE1 . GLU A 1 181 ? -29.712 -2.615  -15.778 0.56 103.00 ? 444  GLU A OE1 1 
ATOM   1193 O  OE2 . GLU A 1 181 ? -31.182 -4.250  -15.653 0.56 108.14 ? 444  GLU A OE2 1 
ATOM   1194 N  N   . GLY A 1 182 ? -25.688 -6.507  -18.571 1.00 84.58  ? 445  GLY A N   1 
ATOM   1195 C  CA  . GLY A 1 182 ? -24.247 -6.724  -18.331 1.00 70.64  ? 445  GLY A CA  1 
ATOM   1196 C  C   . GLY A 1 182 ? -23.936 -6.751  -16.843 1.00 66.38  ? 445  GLY A C   1 
ATOM   1197 O  O   . GLY A 1 182 ? -22.862 -6.272  -16.440 1.00 69.35  ? 445  GLY A O   1 
ATOM   1198 N  N   . LYS A 1 183 ? -24.857 -7.305  -16.048 0.56 63.62  ? 446  LYS A N   1 
ATOM   1199 C  CA  . LYS A 1 183 ? -24.760 -7.412  -14.566 0.56 66.82  ? 446  LYS A CA  1 
ATOM   1200 C  C   . LYS A 1 183 ? -25.156 -8.830  -14.137 0.56 61.33  ? 446  LYS A C   1 
ATOM   1201 O  O   . LYS A 1 183 ? -25.893 -9.493  -14.897 0.56 58.23  ? 446  LYS A O   1 
ATOM   1202 C  CB  . LYS A 1 183 ? -25.683 -6.397  -13.882 0.56 73.66  ? 446  LYS A CB  1 
ATOM   1203 C  CG  . LYS A 1 183 ? -25.601 -4.965  -14.398 0.56 77.61  ? 446  LYS A CG  1 
ATOM   1204 C  CD  . LYS A 1 183 ? -26.897 -4.197  -14.210 0.56 84.42  ? 446  LYS A CD  1 
ATOM   1205 C  CE  . LYS A 1 183 ? -26.756 -2.705  -14.428 0.56 88.69  ? 446  LYS A CE  1 
ATOM   1206 N  NZ  . LYS A 1 183 ? -26.327 -2.010  -13.192 0.56 92.17  ? 446  LYS A NZ  1 
ATOM   1207 N  N   . CYS A 1 184 ? -24.716 -9.252  -12.946 1.00 59.61  ? 447  CYS A N   1 
ATOM   1208 C  CA  . CYS A 1 184 ? -24.911 -10.634 -12.421 1.00 63.07  ? 447  CYS A CA  1 
ATOM   1209 C  C   . CYS A 1 184 ? -25.080 -10.597 -10.902 1.00 60.45  ? 447  CYS A C   1 
ATOM   1210 O  O   . CYS A 1 184 ? -24.367 -9.820  -10.252 1.00 67.21  ? 447  CYS A O   1 
ATOM   1211 C  CB  . CYS A 1 184 ? -23.686 -11.479 -12.773 1.00 65.27  ? 447  CYS A CB  1 
ATOM   1212 S  SG  . CYS A 1 184 ? -23.891 -13.231 -12.372 1.00 56.75  ? 447  CYS A SG  1 
ATOM   1213 N  N   . GLU A 1 185 ? -25.958 -11.447 -10.362 0.50 60.28  ? 448  GLU A N   1 
ATOM   1214 C  CA  . GLU A 1 185 ? -26.391 -11.404 -8.940  0.50 63.29  ? 448  GLU A CA  1 
ATOM   1215 C  C   . GLU A 1 185 ? -26.250 -12.789 -8.295  0.50 63.06  ? 448  GLU A C   1 
ATOM   1216 O  O   . GLU A 1 185 ? -25.847 -12.841 -7.116  0.50 64.53  ? 448  GLU A O   1 
ATOM   1217 C  CB  . GLU A 1 185 ? -27.834 -10.892 -8.857  0.50 67.85  ? 448  GLU A CB  1 
ATOM   1218 C  CG  . GLU A 1 185 ? -28.121 -10.042 -7.627  0.50 69.32  ? 448  GLU A CG  1 
ATOM   1219 C  CD  . GLU A 1 185 ? -29.403 -9.225  -7.698  0.50 69.33  ? 448  GLU A CD  1 
ATOM   1220 O  OE1 . GLU A 1 185 ? -29.406 -8.086  -7.181  0.50 66.30  ? 448  GLU A OE1 1 
ATOM   1221 O  OE2 . GLU A 1 185 ? -30.399 -9.728  -8.267  0.50 72.46  ? 448  GLU A OE2 1 
ATOM   1222 N  N   . THR A 1 186 ? -26.562 -13.867 -9.022  0.56 61.68  ? 449  THR A N   1 
ATOM   1223 C  CA  . THR A 1 186 ? -26.796 -15.211 -8.425  0.56 62.45  ? 449  THR A CA  1 
ATOM   1224 C  C   . THR A 1 186 ? -25.912 -16.295 -9.056  0.56 57.78  ? 449  THR A C   1 
ATOM   1225 O  O   . THR A 1 186 ? -25.988 -17.436 -8.573  0.56 62.08  ? 449  THR A O   1 
ATOM   1226 C  CB  . THR A 1 186 ? -28.273 -15.605 -8.544  0.56 65.65  ? 449  THR A CB  1 
ATOM   1227 O  OG1 . THR A 1 186 ? -28.674 -15.408 -9.902  0.56 65.21  ? 449  THR A OG1 1 
ATOM   1228 C  CG2 . THR A 1 186 ? -29.164 -14.807 -7.619  0.56 67.52  ? 449  THR A CG2 1 
ATOM   1229 N  N   . CYS A 1 187 ? -25.113 -15.976 -10.078 0.50 54.71  ? 450  CYS A N   1 
ATOM   1230 C  CA  . CYS A 1 187 ? -24.292 -16.975 -10.820 0.50 51.22  ? 450  CYS A CA  1 
ATOM   1231 C  C   . CYS A 1 187 ? -22.945 -17.171 -10.102 0.50 50.31  ? 450  CYS A C   1 
ATOM   1232 O  O   . CYS A 1 187 ? -21.943 -16.536 -10.488 0.50 47.35  ? 450  CYS A O   1 
ATOM   1233 C  CB  . CYS A 1 187 ? -24.150 -16.579 -12.286 0.50 50.10  ? 450  CYS A CB  1 
ATOM   1234 S  SG  . CYS A 1 187 ? -25.754 -16.310 -13.096 0.50 49.22  ? 450  CYS A SG  1 
ATOM   1235 N  N   . VAL A 1 188 ? -22.940 -18.042 -9.090  0.44 50.91  ? 451  VAL A N   1 
ATOM   1236 C  CA  . VAL A 1 188 ? -21.797 -18.277 -8.159  0.44 51.96  ? 451  VAL A CA  1 
ATOM   1237 C  C   . VAL A 1 188 ? -21.452 -19.772 -8.152  0.44 50.73  ? 451  VAL A C   1 
ATOM   1238 O  O   . VAL A 1 188 ? -22.378 -20.598 -7.994  0.44 49.07  ? 451  VAL A O   1 
ATOM   1239 C  CB  . VAL A 1 188 ? -22.144 -17.774 -6.744  0.44 53.59  ? 451  VAL A CB  1 
ATOM   1240 C  CG1 . VAL A 1 188 ? -21.172 -18.293 -5.693  0.44 54.67  ? 451  VAL A CG1 1 
ATOM   1241 C  CG2 . VAL A 1 188 ? -22.223 -16.257 -6.702  0.44 54.97  ? 451  VAL A CG2 1 
ATOM   1242 N  N   . TYR A 1 189 ? -20.168 -20.104 -8.306  0.44 50.74  ? 452  TYR A N   1 
ATOM   1243 C  CA  . TYR A 1 189 ? -19.658 -21.501 -8.340  0.44 50.49  ? 452  TYR A CA  1 
ATOM   1244 C  C   . TYR A 1 189 ? -19.611 -22.068 -6.919  0.44 51.32  ? 452  TYR A C   1 
ATOM   1245 O  O   . TYR A 1 189 ? -18.841 -21.558 -6.092  0.44 54.15  ? 452  TYR A O   1 
ATOM   1246 C  CB  . TYR A 1 189 ? -18.286 -21.550 -9.007  0.44 47.50  ? 452  TYR A CB  1 
ATOM   1247 C  CG  . TYR A 1 189 ? -18.300 -21.205 -10.473 0.44 45.90  ? 452  TYR A CG  1 
ATOM   1248 C  CD1 . TYR A 1 189 ? -18.528 -22.175 -11.435 0.44 46.11  ? 452  TYR A CD1 1 
ATOM   1249 C  CD2 . TYR A 1 189 ? -18.077 -19.909 -10.900 0.44 45.34  ? 452  TYR A CD2 1 
ATOM   1250 C  CE1 . TYR A 1 189 ? -18.545 -21.862 -12.785 0.44 45.66  ? 452  TYR A CE1 1 
ATOM   1251 C  CE2 . TYR A 1 189 ? -18.080 -19.580 -12.245 0.44 44.38  ? 452  TYR A CE2 1 
ATOM   1252 C  CZ  . TYR A 1 189 ? -18.317 -20.559 -13.192 0.44 44.97  ? 452  TYR A CZ  1 
ATOM   1253 O  OH  . TYR A 1 189 ? -18.321 -20.237 -14.517 0.44 44.88  ? 452  TYR A OH  1 
ATOM   1254 N  N   . ASN A 1 190 ? -20.413 -23.102 -6.655  0.44 54.50  ? 453  ASN A N   1 
ATOM   1255 C  CA  . ASN A 1 190 ? -20.552 -23.728 -5.313  0.44 56.72  ? 453  ASN A CA  1 
ATOM   1256 C  C   . ASN A 1 190 ? -19.795 -25.062 -5.298  0.44 61.44  ? 453  ASN A C   1 
ATOM   1257 O  O   . ASN A 1 190 ? -20.303 -26.049 -5.863  0.44 60.05  ? 453  ASN A O   1 
ATOM   1258 C  CB  . ASN A 1 190 ? -22.026 -23.858 -4.930  0.44 55.98  ? 453  ASN A CB  1 
ATOM   1259 C  CG  . ASN A 1 190 ? -22.752 -22.532 -5.018  0.44 56.48  ? 453  ASN A CG  1 
ATOM   1260 O  OD1 . ASN A 1 190 ? -22.480 -21.621 -4.238  0.44 56.57  ? 453  ASN A OD1 1 
ATOM   1261 N  ND2 . ASN A 1 190 ? -23.665 -22.408 -5.970  0.44 53.29  ? 453  ASN A ND2 1 
ATOM   1262 N  N   . MET A 1 191 ? -18.615 -25.073 -4.672  0.44 66.14  ? 454  MET A N   1 
ATOM   1263 C  CA  . MET A 1 191 ? -17.739 -26.266 -4.545  0.44 72.18  ? 454  MET A CA  1 
ATOM   1264 C  C   . MET A 1 191 ? -18.236 -27.125 -3.378  0.44 75.03  ? 454  MET A C   1 
ATOM   1265 O  O   . MET A 1 191 ? -19.204 -26.709 -2.706  0.44 76.95  ? 454  MET A O   1 
ATOM   1266 C  CB  . MET A 1 191 ? -16.285 -25.855 -4.297  0.44 74.60  ? 454  MET A CB  1 
ATOM   1267 C  CG  . MET A 1 191 ? -15.303 -26.994 -4.476  0.44 77.90  ? 454  MET A CG  1 
ATOM   1268 S  SD  . MET A 1 191 ? -13.611 -26.524 -4.045  0.44 79.31  ? 454  MET A SD  1 
ATOM   1269 C  CE  . MET A 1 191 ? -13.314 -25.232 -5.251  0.44 80.15  ? 454  MET A CE  1 
ATOM   1270 N  N   . MET A 1 192 ? -17.594 -28.278 -3.161  0.44 76.62  ? 455  MET A N   1 
ATOM   1271 C  CA  . MET A 1 192 ? -17.910 -29.238 -2.070  0.44 77.23  ? 455  MET A CA  1 
ATOM   1272 C  C   . MET A 1 192 ? -16.694 -30.138 -1.823  0.44 75.94  ? 455  MET A C   1 
ATOM   1273 O  O   . MET A 1 192 ? -15.957 -30.374 -2.801  0.44 74.77  ? 455  MET A O   1 
ATOM   1274 C  CB  . MET A 1 192 ? -19.121 -30.104 -2.434  0.44 77.66  ? 455  MET A CB  1 
ATOM   1275 C  CG  . MET A 1 192 ? -20.451 -29.396 -2.255  0.44 76.72  ? 455  MET A CG  1 
ATOM   1276 S  SD  . MET A 1 192 ? -20.762 -28.134 -3.520  0.44 77.50  ? 455  MET A SD  1 
ATOM   1277 C  CE  . MET A 1 192 ? -22.438 -27.661 -3.095  0.44 76.49  ? 455  MET A CE  1 
ATOM   1278 N  N   . ILE A 1 211 ? -14.723 -29.857 -9.109  0.44 73.25  ? 474  ILE A N   1 
ATOM   1279 C  CA  . ILE A 1 211 ? -16.053 -29.635 -9.753  0.44 72.01  ? 474  ILE A CA  1 
ATOM   1280 C  C   . ILE A 1 211 ? -16.845 -28.633 -8.904  0.44 75.95  ? 474  ILE A C   1 
ATOM   1281 O  O   . ILE A 1 211 ? -17.160 -28.959 -7.738  0.44 76.08  ? 474  ILE A O   1 
ATOM   1282 C  CB  . ILE A 1 211 ? -16.810 -30.968 -9.921  0.44 70.41  ? 474  ILE A CB  1 
ATOM   1283 C  CG1 . ILE A 1 211 ? -18.129 -30.787 -10.681 0.44 68.65  ? 474  ILE A CG1 1 
ATOM   1284 C  CG2 . ILE A 1 211 ? -17.023 -31.633 -8.570  0.44 70.47  ? 474  ILE A CG2 1 
ATOM   1285 C  CD1 . ILE A 1 211 ? -18.927 -32.061 -10.861 0.44 66.97  ? 474  ILE A CD1 1 
ATOM   1286 N  N   . TRP A 1 212 ? -17.145 -27.459 -9.469  0.44 78.27  ? 475  TRP A N   1 
ATOM   1287 C  CA  . TRP A 1 212 ? -17.957 -26.394 -8.823  0.44 78.75  ? 475  TRP A CA  1 
ATOM   1288 C  C   . TRP A 1 212 ? -19.394 -26.455 -9.356  0.44 81.29  ? 475  TRP A C   1 
ATOM   1289 O  O   . TRP A 1 212 ? -19.594 -26.146 -10.549 0.44 76.86  ? 475  TRP A O   1 
ATOM   1290 C  CB  . TRP A 1 212 ? -17.331 -25.010 -9.051  0.44 78.28  ? 475  TRP A CB  1 
ATOM   1291 C  CG  . TRP A 1 212 ? -15.864 -24.927 -8.758  0.44 76.78  ? 475  TRP A CG  1 
ATOM   1292 C  CD1 . TRP A 1 212 ? -15.197 -25.504 -7.716  0.44 76.41  ? 475  TRP A CD1 1 
ATOM   1293 C  CD2 . TRP A 1 212 ? -14.877 -24.191 -9.506  0.44 75.20  ? 475  TRP A CD2 1 
ATOM   1294 N  NE1 . TRP A 1 212 ? -13.864 -25.191 -7.773  0.44 76.40  ? 475  TRP A NE1 1 
ATOM   1295 C  CE2 . TRP A 1 212 ? -13.637 -24.388 -8.859  0.44 73.67  ? 475  TRP A CE2 1 
ATOM   1296 C  CE3 . TRP A 1 212 ? -14.916 -23.393 -10.655 0.44 72.97  ? 475  TRP A CE3 1 
ATOM   1297 C  CZ2 . TRP A 1 212 ? -12.454 -23.820 -9.329  0.44 72.67  ? 475  TRP A CZ2 1 
ATOM   1298 C  CZ3 . TRP A 1 212 ? -13.746 -22.835 -11.120 0.44 73.56  ? 475  TRP A CZ3 1 
ATOM   1299 C  CH2 . TRP A 1 212 ? -12.532 -23.049 -10.466 0.44 73.76  ? 475  TRP A CH2 1 
ATOM   1300 N  N   . TYR A 1 213 ? -20.348 -26.849 -8.503  0.44 86.38  ? 476  TYR A N   1 
ATOM   1301 C  CA  . TYR A 1 213 ? -21.811 -26.792 -8.769  0.44 89.50  ? 476  TYR A CA  1 
ATOM   1302 C  C   . TYR A 1 213 ? -22.290 -25.337 -8.652  0.44 87.80  ? 476  TYR A C   1 
ATOM   1303 O  O   . TYR A 1 213 ? -21.896 -24.648 -7.689  0.44 87.55  ? 476  TYR A O   1 
ATOM   1304 C  CB  . TYR A 1 213 ? -22.606 -27.659 -7.784  0.44 94.20  ? 476  TYR A CB  1 
ATOM   1305 C  CG  . TYR A 1 213 ? -22.119 -29.076 -7.598  0.44 97.33  ? 476  TYR A CG  1 
ATOM   1306 C  CD1 . TYR A 1 213 ? -22.203 -30.010 -8.618  0.44 99.82  ? 476  TYR A CD1 1 
ATOM   1307 C  CD2 . TYR A 1 213 ? -21.608 -29.495 -6.380  0.44 100.50 ? 476  TYR A CD2 1 
ATOM   1308 C  CE1 . TYR A 1 213 ? -21.767 -31.313 -8.442  0.44 102.46 ? 476  TYR A CE1 1 
ATOM   1309 C  CE2 . TYR A 1 213 ? -21.168 -30.793 -6.186  0.44 101.28 ? 476  TYR A CE2 1 
ATOM   1310 C  CZ  . TYR A 1 213 ? -21.247 -31.708 -7.221  0.44 104.35 ? 476  TYR A CZ  1 
ATOM   1311 O  OH  . TYR A 1 213 ? -20.812 -32.989 -7.033  0.44 105.71 ? 476  TYR A OH  1 
ATOM   1312 N  N   . MET A 1 214 ? -23.113 -24.891 -9.607  0.44 86.05  ? 477  MET A N   1 
ATOM   1313 C  CA  . MET A 1 214 ? -23.870 -23.610 -9.552  0.44 80.76  ? 477  MET A CA  1 
ATOM   1314 C  C   . MET A 1 214 ? -25.344 -23.933 -9.291  0.44 76.10  ? 477  MET A C   1 
ATOM   1315 O  O   . MET A 1 214 ? -25.706 -25.122 -9.386  0.44 73.72  ? 477  MET A O   1 
ATOM   1316 C  CB  . MET A 1 214 ? -23.751 -22.830 -10.864 0.44 79.49  ? 477  MET A CB  1 
ATOM   1317 C  CG  . MET A 1 214 ? -22.631 -21.808 -10.873 0.44 79.79  ? 477  MET A CG  1 
ATOM   1318 S  SD  . MET A 1 214 ? -22.600 -20.863 -12.420 0.44 80.37  ? 477  MET A SD  1 
ATOM   1319 C  CE  . MET A 1 214 ? -21.441 -19.561 -12.011 0.44 79.70  ? 477  MET A CE  1 
ATOM   1320 N  N   . TRP A 1 215 ? -26.157 -22.922 -8.971  0.44 75.57  ? 478  TRP A N   1 
ATOM   1321 C  CA  . TRP A 1 215 ? -27.623 -23.079 -8.773  0.44 74.66  ? 478  TRP A CA  1 
ATOM   1322 C  C   . TRP A 1 215 ? -28.287 -23.337 -10.133 0.44 70.21  ? 478  TRP A C   1 
ATOM   1323 O  O   . TRP A 1 215 ? -27.839 -22.743 -11.137 0.44 68.59  ? 478  TRP A O   1 
ATOM   1324 C  CB  . TRP A 1 215 ? -28.214 -21.864 -8.048  0.44 76.68  ? 478  TRP A CB  1 
ATOM   1325 C  CG  . TRP A 1 215 ? -28.695 -20.759 -8.937  0.44 80.38  ? 478  TRP A CG  1 
ATOM   1326 C  CD1 . TRP A 1 215 ? -27.935 -19.897 -9.676  0.44 83.00  ? 478  TRP A CD1 1 
ATOM   1327 C  CD2 . TRP A 1 215 ? -30.063 -20.365 -9.149  0.44 83.69  ? 478  TRP A CD2 1 
ATOM   1328 N  NE1 . TRP A 1 215 ? -28.734 -19.009 -10.347 0.44 83.81  ? 478  TRP A NE1 1 
ATOM   1329 C  CE2 . TRP A 1 215 ? -30.045 -19.270 -10.040 0.44 85.34  ? 478  TRP A CE2 1 
ATOM   1330 C  CE3 . TRP A 1 215 ? -31.296 -20.835 -8.680  0.44 82.15  ? 478  TRP A CE3 1 
ATOM   1331 C  CZ2 . TRP A 1 215 ? -31.213 -18.639 -10.466 0.44 83.33  ? 478  TRP A CZ2 1 
ATOM   1332 C  CZ3 . TRP A 1 215 ? -32.449 -20.213 -9.104  0.44 82.72  ? 478  TRP A CZ3 1 
ATOM   1333 C  CH2 . TRP A 1 215 ? -32.405 -19.130 -9.983  0.44 83.97  ? 478  TRP A CH2 1 
ATOM   1334 N  N   . LEU A 1 216 ? -29.297 -24.210 -10.157 0.44 66.60  ? 479  LEU A N   1 
ATOM   1335 C  CA  . LEU A 1 216 ? -29.939 -24.736 -11.391 0.44 67.07  ? 479  LEU A CA  1 
ATOM   1336 C  C   . LEU A 1 216 ? -30.207 -23.595 -12.381 0.44 65.10  ? 479  LEU A C   1 
ATOM   1337 O  O   . LEU A 1 216 ? -29.923 -23.775 -13.582 0.44 67.55  ? 479  LEU A O   1 
ATOM   1338 C  CB  . LEU A 1 216 ? -31.238 -25.447 -11.010 0.44 65.32  ? 479  LEU A CB  1 
ATOM   1339 C  CG  . LEU A 1 216 ? -31.847 -26.300 -12.119 0.44 68.64  ? 479  LEU A CG  1 
ATOM   1340 C  CD1 . LEU A 1 216 ? -30.906 -27.431 -12.502 0.44 69.01  ? 479  LEU A CD1 1 
ATOM   1341 C  CD2 . LEU A 1 216 ? -33.204 -26.846 -11.706 0.44 69.11  ? 479  LEU A CD2 1 
ATOM   1342 N  N   . GLY A 1 217 ? -30.733 -22.469 -11.897 0.50 61.33  ? 480  GLY A N   1 
ATOM   1343 C  CA  . GLY A 1 217 ? -31.093 -21.309 -12.731 0.50 62.59  ? 480  GLY A CA  1 
ATOM   1344 C  C   . GLY A 1 217 ? -29.911 -20.829 -13.551 0.50 62.61  ? 480  GLY A C   1 
ATOM   1345 O  O   . GLY A 1 217 ? -30.079 -20.627 -14.768 0.50 61.98  ? 480  GLY A O   1 
ATOM   1346 N  N   . ALA A 1 218 ? -28.757 -20.645 -12.905 0.50 63.79  ? 481  ALA A N   1 
ATOM   1347 C  CA  . ALA A 1 218 ? -27.478 -20.273 -13.552 0.50 60.47  ? 481  ALA A CA  1 
ATOM   1348 C  C   . ALA A 1 218 ? -27.137 -21.324 -14.615 0.50 58.25  ? 481  ALA A C   1 
ATOM   1349 O  O   . ALA A 1 218 ? -26.756 -20.934 -15.737 0.50 54.17  ? 481  ALA A O   1 
ATOM   1350 C  CB  . ALA A 1 218 ? -26.399 -20.150 -12.509 0.50 58.61  ? 481  ALA A CB  1 
ATOM   1351 N  N   . ARG A 1 219 ? -27.298 -22.610 -14.285 0.50 58.02  ? 482  ARG A N   1 
ATOM   1352 C  CA  . ARG A 1 219 ? -27.069 -23.730 -15.236 0.50 61.59  ? 482  ARG A CA  1 
ATOM   1353 C  C   . ARG A 1 219 ? -27.973 -23.521 -16.454 0.50 59.67  ? 482  ARG A C   1 
ATOM   1354 O  O   . ARG A 1 219 ? -27.471 -23.657 -17.588 0.50 55.75  ? 482  ARG A O   1 
ATOM   1355 C  CB  . ARG A 1 219 ? -27.306 -25.091 -14.574 0.50 65.98  ? 482  ARG A CB  1 
ATOM   1356 C  CG  . ARG A 1 219 ? -26.024 -25.813 -14.185 0.50 74.35  ? 482  ARG A CG  1 
ATOM   1357 C  CD  . ARG A 1 219 ? -25.170 -24.994 -13.235 0.50 82.69  ? 482  ARG A CD  1 
ATOM   1358 N  NE  . ARG A 1 219 ? -23.792 -25.467 -13.148 0.50 89.84  ? 482  ARG A NE  1 
ATOM   1359 C  CZ  . ARG A 1 219 ? -22.768 -24.957 -13.829 0.50 92.82  ? 482  ARG A CZ  1 
ATOM   1360 N  NH1 . ARG A 1 219 ? -22.958 -23.949 -14.664 0.50 94.52  ? 482  ARG A NH1 1 
ATOM   1361 N  NH2 . ARG A 1 219 ? -21.555 -25.458 -13.672 0.50 96.61  ? 482  ARG A NH2 1 
ATOM   1362 N  N   . PHE A 1 220 ? -29.246 -23.176 -16.235 0.56 56.87  ? 483  PHE A N   1 
ATOM   1363 C  CA  . PHE A 1 220 ? -30.226 -22.950 -17.329 0.56 54.97  ? 483  PHE A CA  1 
ATOM   1364 C  C   . PHE A 1 220 ? -29.704 -21.862 -18.273 0.56 52.10  ? 483  PHE A C   1 
ATOM   1365 O  O   . PHE A 1 220 ? -29.746 -22.060 -19.506 0.56 50.12  ? 483  PHE A O   1 
ATOM   1366 C  CB  . PHE A 1 220 ? -31.608 -22.534 -16.824 0.56 55.96  ? 483  PHE A CB  1 
ATOM   1367 C  CG  . PHE A 1 220 ? -32.507 -22.152 -17.969 0.56 53.16  ? 483  PHE A CG  1 
ATOM   1368 C  CD1 . PHE A 1 220 ? -33.025 -23.123 -18.809 0.56 54.69  ? 483  PHE A CD1 1 
ATOM   1369 C  CD2 . PHE A 1 220 ? -32.739 -20.823 -18.275 0.56 54.68  ? 483  PHE A CD2 1 
ATOM   1370 C  CE1 . PHE A 1 220 ? -33.811 -22.776 -19.895 0.56 57.95  ? 483  PHE A CE1 1 
ATOM   1371 C  CE2 . PHE A 1 220 ? -33.526 -20.477 -19.362 0.56 56.83  ? 483  PHE A CE2 1 
ATOM   1372 C  CZ  . PHE A 1 220 ? -34.062 -21.453 -20.168 0.56 57.59  ? 483  PHE A CZ  1 
ATOM   1373 N  N   . LEU A 1 221 ? -29.243 -20.742 -17.712 0.50 51.36  ? 484  LEU A N   1 
ATOM   1374 C  CA  . LEU A 1 221 ? -28.725 -19.585 -18.488 0.50 52.22  ? 484  LEU A CA  1 
ATOM   1375 C  C   . LEU A 1 221 ? -27.534 -20.053 -19.333 0.50 52.89  ? 484  LEU A C   1 
ATOM   1376 O  O   . LEU A 1 221 ? -27.466 -19.660 -20.517 0.50 50.18  ? 484  LEU A O   1 
ATOM   1377 C  CB  . LEU A 1 221 ? -28.344 -18.453 -17.530 0.50 53.05  ? 484  LEU A CB  1 
ATOM   1378 C  CG  . LEU A 1 221 ? -29.516 -17.767 -16.827 0.50 55.31  ? 484  LEU A CG  1 
ATOM   1379 C  CD1 . LEU A 1 221 ? -29.033 -16.599 -15.975 0.50 57.43  ? 484  LEU A CD1 1 
ATOM   1380 C  CD2 . LEU A 1 221 ? -30.555 -17.293 -17.833 0.50 55.97  ? 484  LEU A CD2 1 
ATOM   1381 N  N   . GLU A 1 222 ? -26.654 -20.883 -18.756 0.50 53.58  ? 485  GLU A N   1 
ATOM   1382 C  CA  . GLU A 1 222 ? -25.481 -21.473 -19.460 0.50 52.72  ? 485  GLU A CA  1 
ATOM   1383 C  C   . GLU A 1 222 ? -25.981 -22.313 -20.643 0.50 49.18  ? 485  GLU A C   1 
ATOM   1384 O  O   . GLU A 1 222 ? -25.521 -22.081 -21.774 0.50 46.85  ? 485  GLU A O   1 
ATOM   1385 C  CB  . GLU A 1 222 ? -24.636 -22.323 -18.506 0.50 54.72  ? 485  GLU A CB  1 
ATOM   1386 C  CG  . GLU A 1 222 ? -23.494 -23.036 -19.213 0.50 57.88  ? 485  GLU A CG  1 
ATOM   1387 C  CD  . GLU A 1 222 ? -22.686 -24.001 -18.363 0.50 58.45  ? 485  GLU A CD  1 
ATOM   1388 O  OE1 . GLU A 1 222 ? -21.618 -23.592 -17.868 0.50 58.45  ? 485  GLU A OE1 1 
ATOM   1389 O  OE2 . GLU A 1 222 ? -23.117 -25.162 -18.221 0.50 58.31  ? 485  GLU A OE2 1 
ATOM   1390 N  N   . PHE A 1 223 ? -26.896 -23.248 -20.377 0.50 50.30  ? 486  PHE A N   1 
ATOM   1391 C  CA  . PHE A 1 223 ? -27.538 -24.148 -21.372 0.50 51.81  ? 486  PHE A CA  1 
ATOM   1392 C  C   . PHE A 1 223 ? -28.212 -23.318 -22.473 0.50 52.34  ? 486  PHE A C   1 
ATOM   1393 O  O   . PHE A 1 223 ? -27.955 -23.577 -23.672 0.50 49.33  ? 486  PHE A O   1 
ATOM   1394 C  CB  . PHE A 1 223 ? -28.543 -25.053 -20.660 0.50 51.29  ? 486  PHE A CB  1 
ATOM   1395 C  CG  . PHE A 1 223 ? -29.285 -26.015 -21.549 0.50 51.61  ? 486  PHE A CG  1 
ATOM   1396 C  CD1 . PHE A 1 223 ? -28.639 -27.105 -22.109 0.50 49.97  ? 486  PHE A CD1 1 
ATOM   1397 C  CD2 . PHE A 1 223 ? -30.639 -25.847 -21.793 0.50 51.86  ? 486  PHE A CD2 1 
ATOM   1398 C  CE1 . PHE A 1 223 ? -29.330 -27.997 -22.914 0.50 52.14  ? 486  PHE A CE1 1 
ATOM   1399 C  CE2 . PHE A 1 223 ? -31.329 -26.741 -22.596 0.50 51.56  ? 486  PHE A CE2 1 
ATOM   1400 C  CZ  . PHE A 1 223 ? -30.674 -27.814 -23.154 0.50 52.56  ? 486  PHE A CZ  1 
ATOM   1401 N  N   . GLU A 1 224 ? -29.033 -22.343 -22.072 0.50 51.69  ? 487  GLU A N   1 
ATOM   1402 C  CA  . GLU A 1 224 ? -29.816 -21.469 -22.989 0.50 52.71  ? 487  GLU A CA  1 
ATOM   1403 C  C   . GLU A 1 224 ? -28.868 -20.864 -24.028 0.50 51.15  ? 487  GLU A C   1 
ATOM   1404 O  O   . GLU A 1 224 ? -29.215 -20.858 -25.236 0.50 48.76  ? 487  GLU A O   1 
ATOM   1405 C  CB  . GLU A 1 224 ? -30.539 -20.367 -22.205 0.50 54.61  ? 487  GLU A CB  1 
ATOM   1406 C  CG  . GLU A 1 224 ? -31.111 -19.266 -23.085 0.50 56.43  ? 487  GLU A CG  1 
ATOM   1407 C  CD  . GLU A 1 224 ? -31.982 -18.238 -22.375 0.50 57.80  ? 487  GLU A CD  1 
ATOM   1408 O  OE1 . GLU A 1 224 ? -33.217 -18.320 -22.521 0.50 55.90  ? 487  GLU A OE1 1 
ATOM   1409 O  OE2 . GLU A 1 224 ? -31.425 -17.344 -21.692 0.50 59.28  ? 487  GLU A OE2 1 
ATOM   1410 N  N   . ALA A 1 225 ? -27.712 -20.377 -23.573 0.50 46.77  ? 488  ALA A N   1 
ATOM   1411 C  CA  . ALA A 1 225 ? -26.762 -19.592 -24.389 0.50 46.63  ? 488  ALA A CA  1 
ATOM   1412 C  C   . ALA A 1 225 ? -25.750 -20.513 -25.081 0.50 44.30  ? 488  ALA A C   1 
ATOM   1413 O  O   . ALA A 1 225 ? -25.386 -20.193 -26.235 0.50 44.25  ? 488  ALA A O   1 
ATOM   1414 C  CB  . ALA A 1 225 ? -26.082 -18.563 -23.525 0.50 47.29  ? 488  ALA A CB  1 
ATOM   1415 N  N   . LEU A 1 226 ? -25.314 -21.595 -24.417 1.00 41.63  ? 489  LEU A N   1 
ATOM   1416 C  CA  . LEU A 1 226 ? -24.171 -22.437 -24.922 1.00 40.83  ? 489  LEU A CA  1 
ATOM   1417 C  C   . LEU A 1 226 ? -24.480 -23.918 -25.169 1.00 38.50  ? 489  LEU A C   1 
ATOM   1418 O  O   . LEU A 1 226 ? -23.619 -24.625 -25.772 1.00 38.91  ? 489  LEU A O   1 
ATOM   1419 C  CB  . LEU A 1 226 ? -22.977 -22.245 -23.983 1.00 38.97  ? 489  LEU A CB  1 
ATOM   1420 C  CG  . LEU A 1 226 ? -22.466 -20.804 -23.877 1.00 43.03  ? 489  LEU A CG  1 
ATOM   1421 C  CD1 . LEU A 1 226 ? -21.339 -20.643 -22.855 1.00 45.03  ? 489  LEU A CD1 1 
ATOM   1422 C  CD2 . LEU A 1 226 ? -21.970 -20.299 -25.217 1.00 49.54  ? 489  LEU A CD2 1 
ATOM   1423 N  N   . GLY A 1 227 ? -25.663 -24.380 -24.747 0.50 37.58  ? 490  GLY A N   1 
ATOM   1424 C  CA  . GLY A 1 227 ? -26.102 -25.785 -24.850 0.50 35.18  ? 490  GLY A CA  1 
ATOM   1425 C  C   . GLY A 1 227 ? -26.074 -26.284 -26.281 0.50 34.30  ? 490  GLY A C   1 
ATOM   1426 O  O   . GLY A 1 227 ? -25.914 -27.512 -26.482 0.50 36.46  ? 490  GLY A O   1 
ATOM   1427 N  N   . PHE A 1 228 ? -26.199 -25.374 -27.251 1.00 34.01  ? 491  PHE A N   1 
ATOM   1428 C  CA  . PHE A 1 228 ? -26.205 -25.736 -28.686 1.00 34.05  ? 491  PHE A CA  1 
ATOM   1429 C  C   . PHE A 1 228 ? -24.930 -26.516 -29.028 1.00 34.33  ? 491  PHE A C   1 
ATOM   1430 O  O   . PHE A 1 228 ? -25.014 -27.351 -29.933 1.00 34.12  ? 491  PHE A O   1 
ATOM   1431 C  CB  . PHE A 1 228 ? -26.422 -24.513 -29.583 1.00 34.92  ? 491  PHE A CB  1 
ATOM   1432 C  CG  . PHE A 1 228 ? -25.257 -23.590 -29.726 1.00 33.69  ? 491  PHE A CG  1 
ATOM   1433 C  CD1 . PHE A 1 228 ? -25.061 -22.548 -28.828 1.00 36.69  ? 491  PHE A CD1 1 
ATOM   1434 C  CD2 . PHE A 1 228 ? -24.326 -23.783 -30.721 1.00 38.87  ? 491  PHE A CD2 1 
ATOM   1435 C  CE1 . PHE A 1 228 ? -23.971 -21.710 -28.937 1.00 35.89  ? 491  PHE A CE1 1 
ATOM   1436 C  CE2 . PHE A 1 228 ? -23.238 -22.926 -30.840 1.00 38.39  ? 491  PHE A CE2 1 
ATOM   1437 C  CZ  . PHE A 1 228 ? -23.053 -21.903 -29.944 1.00 36.42  ? 491  PHE A CZ  1 
ATOM   1438 N  N   . LEU A 1 229 ? -23.789 -26.226 -28.384 1.00 36.39  ? 492  LEU A N   1 
ATOM   1439 C  CA  . LEU A 1 229 ? -22.499 -26.866 -28.757 1.00 37.73  ? 492  LEU A CA  1 
ATOM   1440 C  C   . LEU A 1 229 ? -22.619 -28.383 -28.579 1.00 33.06  ? 492  LEU A C   1 
ATOM   1441 O  O   . LEU A 1 229 ? -22.219 -29.135 -29.512 1.00 36.56  ? 492  LEU A O   1 
ATOM   1442 C  CB  . LEU A 1 229 ? -21.367 -26.246 -27.933 1.00 38.61  ? 492  LEU A CB  1 
ATOM   1443 C  CG  . LEU A 1 229 ? -20.993 -24.824 -28.337 1.00 37.53  ? 492  LEU A CG  1 
ATOM   1444 C  CD1 . LEU A 1 229 ? -20.166 -24.168 -27.258 1.00 40.14  ? 492  LEU A CD1 1 
ATOM   1445 C  CD2 . LEU A 1 229 ? -20.280 -24.796 -29.687 1.00 39.69  ? 492  LEU A CD2 1 
ATOM   1446 N  N   . ASN A 1 230 ? -23.218 -28.812 -27.478 1.00 33.11  ? 493  ASN A N   1 
ATOM   1447 C  CA  . ASN A 1 230 ? -23.479 -30.243 -27.193 1.00 35.52  ? 493  ASN A CA  1 
ATOM   1448 C  C   . ASN A 1 230 ? -24.724 -30.750 -27.919 1.00 37.01  ? 493  ASN A C   1 
ATOM   1449 O  O   . ASN A 1 230 ? -24.628 -31.765 -28.654 1.00 36.27  ? 493  ASN A O   1 
ATOM   1450 C  CB  . ASN A 1 230 ? -23.669 -30.507 -25.696 1.00 46.53  ? 493  ASN A CB  1 
ATOM   1451 C  CG  . ASN A 1 230 ? -23.960 -31.977 -25.429 1.00 58.68  ? 493  ASN A CG  1 
ATOM   1452 O  OD1 . ASN A 1 230 ? -25.028 -32.349 -24.926 1.00 69.50  ? 493  ASN A OD1 1 
ATOM   1453 N  ND2 . ASN A 1 230 ? -23.023 -32.840 -25.802 1.00 66.01  ? 493  ASN A ND2 1 
ATOM   1454 N  N   . GLU A 1 231 ? -25.862 -30.066 -27.720 0.50 38.16  ? 494  GLU A N   1 
ATOM   1455 C  CA  . GLU A 1 231 ? -27.201 -30.481 -28.232 0.50 37.86  ? 494  GLU A CA  1 
ATOM   1456 C  C   . GLU A 1 231 ? -27.151 -30.678 -29.753 0.50 36.94  ? 494  GLU A C   1 
ATOM   1457 O  O   . GLU A 1 231 ? -27.800 -31.633 -30.240 0.50 36.34  ? 494  GLU A O   1 
ATOM   1458 C  CB  . GLU A 1 231 ? -28.269 -29.440 -27.894 0.50 38.89  ? 494  GLU A CB  1 
ATOM   1459 C  CG  . GLU A 1 231 ? -28.657 -29.390 -26.426 0.50 40.47  ? 494  GLU A CG  1 
ATOM   1460 C  CD  . GLU A 1 231 ? -29.368 -30.618 -25.874 0.50 42.48  ? 494  GLU A CD  1 
ATOM   1461 O  OE1 . GLU A 1 231 ? -30.114 -31.292 -26.636 0.50 39.58  ? 494  GLU A OE1 1 
ATOM   1462 O  OE2 . GLU A 1 231 ? -29.172 -30.897 -24.670 0.50 44.53  ? 494  GLU A OE2 1 
ATOM   1463 N  N   . ASP A 1 232 ? -26.420 -29.808 -30.467 1.00 34.63  ? 495  ASP A N   1 
ATOM   1464 C  CA  . ASP A 1 232 ? -26.344 -29.829 -31.955 1.00 33.05  ? 495  ASP A CA  1 
ATOM   1465 C  C   . ASP A 1 232 ? -24.991 -30.406 -32.432 1.00 34.12  ? 495  ASP A C   1 
ATOM   1466 O  O   . ASP A 1 232 ? -24.688 -30.318 -33.647 1.00 32.02  ? 495  ASP A O   1 
ATOM   1467 C  CB  . ASP A 1 232 ? -26.640 -28.422 -32.505 1.00 41.34  ? 495  ASP A CB  1 
ATOM   1468 C  CG  . ASP A 1 232 ? -28.022 -27.870 -32.145 1.00 38.34  ? 495  ASP A CG  1 
ATOM   1469 O  OD1 . ASP A 1 232 ? -28.891 -28.675 -31.859 1.00 40.84  ? 495  ASP A OD1 1 
ATOM   1470 O  OD2 . ASP A 1 232 ? -28.184 -26.640 -32.080 1.00 41.32  ? 495  ASP A OD2 1 
ATOM   1471 N  N   . HIS A 1 233 ? -24.194 -31.005 -31.546 1.00 34.28  ? 496  HIS A N   1 
ATOM   1472 C  CA  . HIS A 1 233 ? -23.075 -31.902 -31.953 1.00 34.92  ? 496  HIS A CA  1 
ATOM   1473 C  C   . HIS A 1 233 ? -22.014 -31.117 -32.740 1.00 29.21  ? 496  HIS A C   1 
ATOM   1474 O  O   . HIS A 1 233 ? -21.603 -31.545 -33.808 1.00 32.12  ? 496  HIS A O   1 
ATOM   1475 C  CB  . HIS A 1 233 ? -23.642 -33.089 -32.754 1.00 37.47  ? 496  HIS A CB  1 
ATOM   1476 C  CG  . HIS A 1 233 ? -24.671 -33.857 -32.001 1.00 45.08  ? 496  HIS A CG  1 
ATOM   1477 N  ND1 . HIS A 1 233 ? -24.456 -34.276 -30.708 1.00 47.60  ? 496  HIS A ND1 1 
ATOM   1478 C  CD2 . HIS A 1 233 ? -25.956 -34.193 -32.306 1.00 49.75  ? 496  HIS A CD2 1 
ATOM   1479 C  CE1 . HIS A 1 233 ? -25.547 -34.893 -30.264 1.00 51.93  ? 496  HIS A CE1 1 
ATOM   1480 N  NE2 . HIS A 1 233 ? -26.470 -34.870 -31.234 1.00 46.50  ? 496  HIS A NE2 1 
ATOM   1481 N  N   . TRP A 1 234 ? -21.600 -29.973 -32.241 1.00 29.41  ? 497  TRP A N   1 
ATOM   1482 C  CA  . TRP A 1 234 ? -20.552 -29.164 -32.911 1.00 34.40  ? 497  TRP A CA  1 
ATOM   1483 C  C   . TRP A 1 234 ? -19.218 -29.946 -32.932 1.00 36.27  ? 497  TRP A C   1 
ATOM   1484 O  O   . TRP A 1 234 ? -18.515 -29.849 -33.957 1.00 30.48  ? 497  TRP A O   1 
ATOM   1485 C  CB  . TRP A 1 234 ? -20.424 -27.778 -32.269 1.00 33.38  ? 497  TRP A CB  1 
ATOM   1486 C  CG  . TRP A 1 234 ? -21.446 -26.815 -32.797 1.00 40.26  ? 497  TRP A CG  1 
ATOM   1487 C  CD1 . TRP A 1 234 ? -22.795 -27.024 -32.866 1.00 43.06  ? 497  TRP A CD1 1 
ATOM   1488 C  CD2 . TRP A 1 234 ? -21.222 -25.506 -33.344 1.00 42.37  ? 497  TRP A CD2 1 
ATOM   1489 N  NE1 . TRP A 1 234 ? -23.411 -25.943 -33.428 1.00 41.69  ? 497  TRP A NE1 1 
ATOM   1490 C  CE2 . TRP A 1 234 ? -22.487 -24.987 -33.711 1.00 45.11  ? 497  TRP A CE2 1 
ATOM   1491 C  CE3 . TRP A 1 234 ? -20.093 -24.705 -33.549 1.00 40.10  ? 497  TRP A CE3 1 
ATOM   1492 C  CZ2 . TRP A 1 234 ? -22.650 -23.723 -34.282 1.00 39.30  ? 497  TRP A CZ2 1 
ATOM   1493 C  CZ3 . TRP A 1 234 ? -20.256 -23.457 -34.105 1.00 39.31  ? 497  TRP A CZ3 1 
ATOM   1494 C  CH2 . TRP A 1 234 ? -21.517 -22.980 -34.478 1.00 36.78  ? 497  TRP A CH2 1 
ATOM   1495 N  N   . PHE A 1 235 ? -18.968 -30.813 -31.941 1.00 33.27  ? 498  PHE A N   1 
ATOM   1496 C  CA  . PHE A 1 235 ? -17.715 -31.607 -31.846 1.00 35.34  ? 498  PHE A CA  1 
ATOM   1497 C  C   . PHE A 1 235 ? -17.928 -33.057 -32.314 1.00 34.05  ? 498  PHE A C   1 
ATOM   1498 O  O   . PHE A 1 235 ? -17.085 -33.901 -32.021 1.00 33.58  ? 498  PHE A O   1 
ATOM   1499 C  CB  . PHE A 1 235 ? -17.161 -31.409 -30.438 1.00 33.40  ? 498  PHE A CB  1 
ATOM   1500 C  CG  . PHE A 1 235 ? -16.855 -29.956 -30.228 1.00 34.63  ? 498  PHE A CG  1 
ATOM   1501 C  CD1 . PHE A 1 235 ? -15.789 -29.366 -30.876 1.00 35.31  ? 498  PHE A CD1 1 
ATOM   1502 C  CD2 . PHE A 1 235 ? -17.710 -29.157 -29.489 1.00 36.89  ? 498  PHE A CD2 1 
ATOM   1503 C  CE1 . PHE A 1 235 ? -15.560 -28.003 -30.760 1.00 41.88  ? 498  PHE A CE1 1 
ATOM   1504 C  CE2 . PHE A 1 235 ? -17.470 -27.793 -29.367 1.00 37.25  ? 498  PHE A CE2 1 
ATOM   1505 C  CZ  . PHE A 1 235 ? -16.415 -27.216 -30.005 1.00 36.64  ? 498  PHE A CZ  1 
ATOM   1506 N  N   . SER A 1 236 ? -18.911 -33.275 -33.179 1.00 31.81  ? 499  SER A N   1 
ATOM   1507 C  CA  . SER A 1 236 ? -19.058 -34.591 -33.836 1.00 32.44  ? 499  SER A CA  1 
ATOM   1508 C  C   . SER A 1 236 ? -17.858 -34.743 -34.770 1.00 32.85  ? 499  SER A C   1 
ATOM   1509 O  O   . SER A 1 236 ? -17.316 -33.721 -35.170 1.00 34.34  ? 499  SER A O   1 
ATOM   1510 C  CB  . SER A 1 236 ? -20.309 -34.623 -34.638 1.00 34.71  ? 499  SER A CB  1 
ATOM   1511 O  OG  . SER A 1 236 ? -20.226 -33.730 -35.733 1.00 34.68  ? 499  SER A OG  1 
ATOM   1512 N  N   . ARG A 1 237 ? -17.502 -35.965 -35.149 1.00 33.00  ? 500  ARG A N   1 
ATOM   1513 C  CA  . ARG A 1 237 ? -16.391 -36.150 -36.116 1.00 35.87  ? 500  ARG A CA  1 
ATOM   1514 C  C   . ARG A 1 237 ? -16.782 -35.578 -37.483 1.00 39.83  ? 500  ARG A C   1 
ATOM   1515 O  O   . ARG A 1 237 ? -15.927 -34.963 -38.116 1.00 33.95  ? 500  ARG A O   1 
ATOM   1516 C  CB  . ARG A 1 237 ? -15.967 -37.616 -36.210 1.00 36.16  ? 500  ARG A CB  1 
ATOM   1517 C  CG  . ARG A 1 237 ? -14.587 -37.808 -36.815 1.00 34.89  ? 500  ARG A CG  1 
ATOM   1518 C  CD  . ARG A 1 237 ? -13.883 -39.044 -36.303 1.00 35.37  ? 500  ARG A CD  1 
ATOM   1519 N  NE  . ARG A 1 237 ? -12.512 -39.083 -36.779 1.00 31.83  ? 500  ARG A NE  1 
ATOM   1520 C  CZ  . ARG A 1 237 ? -11.492 -38.490 -36.176 1.00 32.13  ? 500  ARG A CZ  1 
ATOM   1521 N  NH1 . ARG A 1 237 ? -11.687 -37.806 -35.064 1.00 28.99  ? 500  ARG A NH1 1 
ATOM   1522 N  NH2 . ARG A 1 237 ? -10.280 -38.584 -36.690 1.00 36.12  ? 500  ARG A NH2 1 
ATOM   1523 N  N   . GLU A 1 238 ? -18.035 -35.770 -37.898 0.56 40.61  ? 501  GLU A N   1 
ATOM   1524 C  CA  . GLU A 1 238 ? -18.487 -35.301 -39.234 0.56 41.95  ? 501  GLU A CA  1 
ATOM   1525 C  C   . GLU A 1 238 ? -18.314 -33.784 -39.327 0.56 37.75  ? 501  GLU A C   1 
ATOM   1526 O  O   . GLU A 1 238 ? -17.901 -33.309 -40.387 0.56 38.44  ? 501  GLU A O   1 
ATOM   1527 C  CB  . GLU A 1 238 ? -19.939 -35.718 -39.468 0.56 47.02  ? 501  GLU A CB  1 
ATOM   1528 C  CG  . GLU A 1 238 ? -20.469 -35.360 -40.843 0.56 51.46  ? 501  GLU A CG  1 
ATOM   1529 C  CD  . GLU A 1 238 ? -21.838 -35.940 -41.152 0.56 57.60  ? 501  GLU A CD  1 
ATOM   1530 O  OE1 . GLU A 1 238 ? -22.358 -35.671 -42.251 0.56 60.97  ? 501  GLU A OE1 1 
ATOM   1531 O  OE2 . GLU A 1 238 ? -22.380 -36.664 -40.295 0.56 64.25  ? 501  GLU A OE2 1 
ATOM   1532 N  N   . ASN A 1 239 ? -18.597 -33.068 -38.244 1.00 36.89  ? 502  ASN A N   1 
ATOM   1533 C  CA  . ASN A 1 239 ? -18.538 -31.583 -38.259 1.00 37.31  ? 502  ASN A CA  1 
ATOM   1534 C  C   . ASN A 1 239 ? -17.151 -31.041 -37.894 1.00 40.15  ? 502  ASN A C   1 
ATOM   1535 O  O   . ASN A 1 239 ? -16.760 -30.055 -38.512 1.00 39.10  ? 502  ASN A O   1 
ATOM   1536 C  CB  . ASN A 1 239 ? -19.559 -30.967 -37.304 1.00 33.34  ? 502  ASN A CB  1 
ATOM   1537 C  CG  . ASN A 1 239 ? -19.740 -29.481 -37.517 1.00 37.62  ? 502  ASN A CG  1 
ATOM   1538 O  OD1 . ASN A 1 239 ? -20.095 -29.049 -38.607 1.00 42.00  ? 502  ASN A OD1 1 
ATOM   1539 N  ND2 . ASN A 1 239 ? -19.501 -28.693 -36.485 1.00 36.54  ? 502  ASN A ND2 1 
ATOM   1540 N  N   . SER A 1 240 ? -16.457 -31.643 -36.927 1.00 33.60  ? 503  SER A N   1 
ATOM   1541 C  CA  . SER A 1 240 ? -15.171 -31.093 -36.414 1.00 33.70  ? 503  SER A CA  1 
ATOM   1542 C  C   . SER A 1 240 ? -13.944 -31.810 -36.992 1.00 30.79  ? 503  SER A C   1 
ATOM   1543 O  O   . SER A 1 240 ? -12.872 -31.228 -36.897 1.00 32.32  ? 503  SER A O   1 
ATOM   1544 C  CB  . SER A 1 240 ? -15.156 -31.137 -34.910 1.00 33.07  ? 503  SER A CB  1 
ATOM   1545 O  OG  . SER A 1 240 ? -15.107 -32.471 -34.438 1.00 35.98  ? 503  SER A OG  1 
ATOM   1546 N  N   . LEU A 1 241 ? -14.100 -33.028 -37.511 1.00 33.00  ? 504  LEU A N   1 
ATOM   1547 C  CA  . LEU A 1 241 ? -12.992 -33.819 -38.128 1.00 38.20  ? 504  LEU A CA  1 
ATOM   1548 C  C   . LEU A 1 241 ? -12.049 -34.423 -37.065 1.00 38.13  ? 504  LEU A C   1 
ATOM   1549 O  O   . LEU A 1 241 ? -11.652 -35.574 -37.235 1.00 32.75  ? 504  LEU A O   1 
ATOM   1550 C  CB  . LEU A 1 241 ? -12.244 -32.941 -39.137 1.00 42.16  ? 504  LEU A CB  1 
ATOM   1551 C  CG  . LEU A 1 241 ? -13.040 -32.495 -40.360 1.00 50.46  ? 504  LEU A CG  1 
ATOM   1552 C  CD1 . LEU A 1 241 ? -12.148 -31.740 -41.332 1.00 48.69  ? 504  LEU A CD1 1 
ATOM   1553 C  CD2 . LEU A 1 241 ? -13.675 -33.688 -41.053 1.00 55.49  ? 504  LEU A CD2 1 
ATOM   1554 N  N   . SER A 1 242 ? -11.715 -33.675 -36.016 1.00 31.69  ? 505  SER A N   1 
ATOM   1555 C  CA  . SER A 1 242 ? -10.824 -34.165 -34.934 1.00 33.89  ? 505  SER A CA  1 
ATOM   1556 C  C   . SER A 1 242 ? -11.658 -34.697 -33.766 1.00 31.23  ? 505  SER A C   1 
ATOM   1557 O  O   . SER A 1 242 ? -11.166 -35.539 -33.026 1.00 28.38  ? 505  SER A O   1 
ATOM   1558 C  CB  . SER A 1 242 ? -9.891  -33.063 -34.480 1.00 32.45  ? 505  SER A CB  1 
ATOM   1559 O  OG  . SER A 1 242 ? -9.254  -32.432 -35.570 1.00 31.58  ? 505  SER A OG  1 
ATOM   1560 N  N   . GLY A 1 243 ? -12.889 -34.218 -33.634 1.00 32.52  ? 506  GLY A N   1 
ATOM   1561 C  CA  . GLY A 1 243 ? -13.735 -34.576 -32.487 1.00 26.73  ? 506  GLY A CA  1 
ATOM   1562 C  C   . GLY A 1 243 ? -14.311 -35.973 -32.524 1.00 28.11  ? 506  GLY A C   1 
ATOM   1563 O  O   . GLY A 1 243 ? -14.216 -36.623 -33.567 1.00 28.58  ? 506  GLY A O   1 
ATOM   1564 N  N   . VAL A 1 244 ? -14.902 -36.390 -31.408 1.00 29.02  ? 507  VAL A N   1 
ATOM   1565 C  CA  . VAL A 1 244 ? -15.496 -37.748 -31.284 1.00 36.47  ? 507  VAL A CA  1 
ATOM   1566 C  C   . VAL A 1 244 ? -16.789 -37.679 -30.445 1.00 35.84  ? 507  VAL A C   1 
ATOM   1567 O  O   . VAL A 1 244 ? -17.215 -38.726 -29.960 1.00 33.92  ? 507  VAL A O   1 
ATOM   1568 C  CB  . VAL A 1 244 ? -14.467 -38.720 -30.668 1.00 35.10  ? 507  VAL A CB  1 
ATOM   1569 C  CG1 . VAL A 1 244 ? -13.286 -38.972 -31.590 1.00 35.84  ? 507  VAL A CG1 1 
ATOM   1570 C  CG2 . VAL A 1 244 ? -13.997 -38.257 -29.300 1.00 31.30  ? 507  VAL A CG2 1 
ATOM   1571 N  N   . GLU A 1 245 ? -17.383 -36.492 -30.278 0.50 36.61  ? 508  GLU A N   1 
ATOM   1572 C  CA  . GLU A 1 245 ? -18.596 -36.354 -29.421 0.50 39.02  ? 508  GLU A CA  1 
ATOM   1573 C  C   . GLU A 1 245 ? -19.714 -37.219 -30.017 0.50 37.22  ? 508  GLU A C   1 
ATOM   1574 O  O   . GLU A 1 245 ? -19.881 -37.209 -31.250 0.50 34.75  ? 508  GLU A O   1 
ATOM   1575 C  CB  . GLU A 1 245 ? -19.054 -34.904 -29.263 0.50 39.45  ? 508  GLU A CB  1 
ATOM   1576 C  CG  . GLU A 1 245 ? -19.993 -34.709 -28.080 0.50 41.85  ? 508  GLU A CG  1 
ATOM   1577 C  CD  . GLU A 1 245 ? -21.382 -35.310 -28.246 0.50 42.74  ? 508  GLU A CD  1 
ATOM   1578 O  OE1 . GLU A 1 245 ? -21.923 -35.237 -29.377 0.50 42.66  ? 508  GLU A OE1 1 
ATOM   1579 O  OE2 . GLU A 1 245 ? -21.927 -35.849 -27.245 0.50 44.84  ? 508  GLU A OE2 1 
ATOM   1580 N  N   . GLY A 1 246 ? -20.344 -38.038 -29.167 0.50 40.80  ? 509  GLY A N   1 
ATOM   1581 C  CA  . GLY A 1 246 ? -21.461 -38.902 -29.595 0.50 43.60  ? 509  GLY A CA  1 
ATOM   1582 C  C   . GLY A 1 246 ? -21.024 -40.169 -30.305 0.50 46.26  ? 509  GLY A C   1 
ATOM   1583 O  O   . GLY A 1 246 ? -21.912 -40.921 -30.728 0.50 45.97  ? 509  GLY A O   1 
ATOM   1584 N  N   . GLU A 1 247 ? -19.718 -40.417 -30.425 0.50 45.69  ? 510  GLU A N   1 
ATOM   1585 C  CA  . GLU A 1 247 ? -19.257 -41.580 -31.234 0.50 44.54  ? 510  GLU A CA  1 
ATOM   1586 C  C   . GLU A 1 247 ? -19.500 -42.902 -30.492 0.50 45.54  ? 510  GLU A C   1 
ATOM   1587 O  O   . GLU A 1 247 ? -20.108 -43.794 -31.101 0.50 48.99  ? 510  GLU A O   1 
ATOM   1588 C  CB  . GLU A 1 247 ? -17.798 -41.399 -31.667 0.50 42.87  ? 510  GLU A CB  1 
ATOM   1589 C  CG  . GLU A 1 247 ? -17.583 -40.176 -32.538 0.50 42.70  ? 510  GLU A CG  1 
ATOM   1590 C  CD  . GLU A 1 247 ? -18.459 -40.092 -33.775 0.50 41.22  ? 510  GLU A CD  1 
ATOM   1591 O  OE1 . GLU A 1 247 ? -18.693 -41.140 -34.403 0.50 43.82  ? 510  GLU A OE1 1 
ATOM   1592 O  OE2 . GLU A 1 247 ? -18.911 -38.975 -34.102 0.50 39.64  ? 510  GLU A OE2 1 
ATOM   1593 N  N   . GLY A 1 248 ? -19.060 -43.030 -29.241 0.50 45.93  ? 511  GLY A N   1 
ATOM   1594 C  CA  . GLY A 1 248 ? -19.197 -44.327 -28.550 0.50 47.31  ? 511  GLY A CA  1 
ATOM   1595 C  C   . GLY A 1 248 ? -17.881 -45.077 -28.464 0.50 46.11  ? 511  GLY A C   1 
ATOM   1596 O  O   . GLY A 1 248 ? -17.207 -45.143 -29.502 0.50 46.22  ? 511  GLY A O   1 
ATOM   1597 N  N   A LEU A 1 249 ? -17.737 -45.923 -27.440 0.19 44.06  ? 512  LEU A N   1 
ATOM   1598 N  N   B LEU A 1 249 ? -17.730 -45.915 -27.433 0.19 43.14  ? 512  LEU A N   1 
ATOM   1599 C  CA  A LEU A 1 249 ? -16.467 -46.673 -27.239 0.19 41.77  ? 512  LEU A CA  1 
ATOM   1600 C  CA  B LEU A 1 249 ? -16.468 -46.681 -27.240 0.19 40.43  ? 512  LEU A CA  1 
ATOM   1601 C  C   A LEU A 1 249 ? -16.292 -47.702 -28.359 0.19 40.31  ? 512  LEU A C   1 
ATOM   1602 C  C   B LEU A 1 249 ? -16.291 -47.680 -28.383 0.19 39.43  ? 512  LEU A C   1 
ATOM   1603 O  O   A LEU A 1 249 ? -15.168 -48.215 -28.500 0.19 40.12  ? 512  LEU A O   1 
ATOM   1604 O  O   B LEU A 1 249 ? -15.166 -48.190 -28.525 0.19 38.87  ? 512  LEU A O   1 
ATOM   1605 C  CB  A LEU A 1 249 ? -16.533 -47.346 -25.865 0.19 41.67  ? 512  LEU A CB  1 
ATOM   1606 C  CB  B LEU A 1 249 ? -16.530 -47.406 -25.893 0.19 39.73  ? 512  LEU A CB  1 
ATOM   1607 C  CG  A LEU A 1 249 ? -15.203 -47.816 -25.281 0.19 40.72  ? 512  LEU A CG  1 
ATOM   1608 C  CG  B LEU A 1 249 ? -15.588 -46.880 -24.812 0.19 38.71  ? 512  LEU A CG  1 
ATOM   1609 C  CD1 A LEU A 1 249 ? -14.204 -46.672 -25.215 0.19 40.88  ? 512  LEU A CD1 1 
ATOM   1610 C  CD1 B LEU A 1 249 ? -15.743 -47.685 -23.531 0.19 38.61  ? 512  LEU A CD1 1 
ATOM   1611 C  CD2 A LEU A 1 249 ? -15.411 -48.423 -23.903 0.19 40.44  ? 512  LEU A CD2 1 
ATOM   1612 C  CD2 B LEU A 1 249 ? -14.145 -46.915 -25.290 0.19 38.55  ? 512  LEU A CD2 1 
ATOM   1613 N  N   . HIS A 1 250 ? -17.404 -48.186 -28.919 0.50 39.26  ? 513  HIS A N   1 
ATOM   1614 C  CA  . HIS A 1 250 ? -17.342 -49.188 -30.019 0.50 38.13  ? 513  HIS A CA  1 
ATOM   1615 C  C   . HIS A 1 250 ? -16.892 -48.545 -31.336 0.50 36.43  ? 513  HIS A C   1 
ATOM   1616 O  O   . HIS A 1 250 ? -16.739 -49.284 -32.318 0.50 37.33  ? 513  HIS A O   1 
ATOM   1617 C  CB  . HIS A 1 250 ? -18.713 -49.853 -30.178 0.50 39.62  ? 513  HIS A CB  1 
ATOM   1618 C  CG  . HIS A 1 250 ? -19.801 -48.886 -30.497 0.50 37.68  ? 513  HIS A CG  1 
ATOM   1619 N  ND1 . HIS A 1 250 ? -20.294 -48.000 -29.564 0.50 36.12  ? 513  HIS A ND1 1 
ATOM   1620 C  CD2 . HIS A 1 250 ? -20.486 -48.659 -31.637 0.50 37.28  ? 513  HIS A CD2 1 
ATOM   1621 C  CE1 . HIS A 1 250 ? -21.235 -47.265 -30.116 0.50 37.64  ? 513  HIS A CE1 1 
ATOM   1622 N  NE2 . HIS A 1 250 ? -21.376 -47.653 -31.385 0.50 38.02  ? 513  HIS A NE2 1 
ATOM   1623 N  N   . LYS A 1 251 ? -16.703 -47.225 -31.355 0.50 36.11  ? 514  LYS A N   1 
ATOM   1624 C  CA  . LYS A 1 251 ? -16.316 -46.512 -32.600 0.50 37.26  ? 514  LYS A CA  1 
ATOM   1625 C  C   . LYS A 1 251 ? -14.917 -45.906 -32.450 0.50 34.66  ? 514  LYS A C   1 
ATOM   1626 O  O   . LYS A 1 251 ? -14.250 -45.720 -33.473 0.50 31.66  ? 514  LYS A O   1 
ATOM   1627 C  CB  . LYS A 1 251 ? -17.343 -45.417 -32.886 0.50 41.08  ? 514  LYS A CB  1 
ATOM   1628 C  CG  . LYS A 1 251 ? -18.793 -45.878 -32.880 0.50 46.12  ? 514  LYS A CG  1 
ATOM   1629 C  CD  . LYS A 1 251 ? -19.440 -45.839 -34.244 0.50 49.29  ? 514  LYS A CD  1 
ATOM   1630 C  CE  . LYS A 1 251 ? -19.470 -44.448 -34.838 0.50 51.55  ? 514  LYS A CE  1 
ATOM   1631 N  NZ  . LYS A 1 251 ? -20.261 -44.405 -36.090 0.50 54.30  ? 514  LYS A NZ  1 
ATOM   1632 N  N   . LEU A 1 252 ? -14.490 -45.635 -31.219 1.00 33.35  ? 515  LEU A N   1 
ATOM   1633 C  CA  . LEU A 1 252 ? -13.193 -44.944 -30.977 1.00 33.15  ? 515  LEU A CA  1 
ATOM   1634 C  C   . LEU A 1 252 ? -12.015 -45.732 -31.569 1.00 32.85  ? 515  LEU A C   1 
ATOM   1635 O  O   . LEU A 1 252 ? -11.155 -45.106 -32.191 1.00 32.29  ? 515  LEU A O   1 
ATOM   1636 C  CB  . LEU A 1 252 ? -13.033 -44.712 -29.473 1.00 31.70  ? 515  LEU A CB  1 
ATOM   1637 C  CG  . LEU A 1 252 ? -14.066 -43.789 -28.831 1.00 33.27  ? 515  LEU A CG  1 
ATOM   1638 C  CD1 . LEU A 1 252 ? -13.688 -43.485 -27.392 1.00 33.88  ? 515  LEU A CD1 1 
ATOM   1639 C  CD2 . LEU A 1 252 ? -14.203 -42.500 -29.624 1.00 34.28  ? 515  LEU A CD2 1 
ATOM   1640 N  N   . GLY A 1 253 ? -12.000 -47.048 -31.391 1.00 28.22  ? 516  GLY A N   1 
ATOM   1641 C  CA  . GLY A 1 253 ? -10.915 -47.878 -31.934 1.00 29.92  ? 516  GLY A CA  1 
ATOM   1642 C  C   . GLY A 1 253 ? -10.862 -47.812 -33.446 1.00 32.24  ? 516  GLY A C   1 
ATOM   1643 O  O   . GLY A 1 253 ? -9.767  -47.702 -33.992 1.00 35.35  ? 516  GLY A O   1 
ATOM   1644 N  N   . TYR A 1 254 ? -12.019 -47.884 -34.089 1.00 28.66  ? 517  TYR A N   1 
ATOM   1645 C  CA  . TYR A 1 254 ? -12.079 -47.763 -35.564 1.00 30.62  ? 517  TYR A CA  1 
ATOM   1646 C  C   . TYR A 1 254 ? -11.572 -46.392 -36.030 1.00 30.76  ? 517  TYR A C   1 
ATOM   1647 O  O   . TYR A 1 254 ? -10.950 -46.269 -37.071 1.00 31.09  ? 517  TYR A O   1 
ATOM   1648 C  CB  . TYR A 1 254 ? -13.509 -47.941 -36.074 1.00 33.16  ? 517  TYR A CB  1 
ATOM   1649 C  CG  . TYR A 1 254 ? -14.003 -49.357 -36.078 1.00 29.67  ? 517  TYR A CG  1 
ATOM   1650 C  CD1 . TYR A 1 254 ? -13.497 -50.271 -36.988 1.00 31.90  ? 517  TYR A CD1 1 
ATOM   1651 C  CD2 . TYR A 1 254 ? -14.942 -49.795 -35.158 1.00 29.57  ? 517  TYR A CD2 1 
ATOM   1652 C  CE1 . TYR A 1 254 ? -13.946 -51.582 -37.028 1.00 29.99  ? 517  TYR A CE1 1 
ATOM   1653 C  CE2 . TYR A 1 254 ? -15.432 -51.098 -35.208 1.00 30.49  ? 517  TYR A CE2 1 
ATOM   1654 C  CZ  . TYR A 1 254 ? -14.920 -51.998 -36.137 1.00 32.26  ? 517  TYR A CZ  1 
ATOM   1655 O  OH  . TYR A 1 254 ? -15.358 -53.302 -36.201 1.00 33.04  ? 517  TYR A OH  1 
ATOM   1656 N  N   . ILE A 1 255 ? -11.877 -45.350 -35.264 0.50 31.38  ? 518  ILE A N   1 
ATOM   1657 C  CA  . ILE A 1 255 ? -11.438 -43.965 -35.586 0.50 33.23  ? 518  ILE A CA  1 
ATOM   1658 C  C   . ILE A 1 255 ? -9.901  -43.906 -35.494 0.50 34.13  ? 518  ILE A C   1 
ATOM   1659 O  O   . ILE A 1 255 ? -9.282  -43.446 -36.469 0.50 35.07  ? 518  ILE A O   1 
ATOM   1660 C  CB  . ILE A 1 255 ? -12.167 -42.943 -34.689 0.50 33.29  ? 518  ILE A CB  1 
ATOM   1661 C  CG1 . ILE A 1 255 ? -13.658 -42.867 -35.045 0.50 33.12  ? 518  ILE A CG1 1 
ATOM   1662 C  CG2 . ILE A 1 255 ? -11.487 -41.583 -34.771 0.50 33.85  ? 518  ILE A CG2 1 
ATOM   1663 C  CD1 . ILE A 1 255 ? -14.479 -41.986 -34.126 0.50 33.42  ? 518  ILE A CD1 1 
ATOM   1664 N  N   . LEU A 1 256 ? -9.308  -44.412 -34.407 0.50 33.97  ? 519  LEU A N   1 
ATOM   1665 C  CA  . LEU A 1 256 ? -7.829  -44.467 -34.217 0.50 36.42  ? 519  LEU A CA  1 
ATOM   1666 C  C   . LEU A 1 256 ? -7.182  -45.272 -35.353 0.50 35.90  ? 519  LEU A C   1 
ATOM   1667 O  O   . LEU A 1 256 ? -6.100  -44.856 -35.835 0.50 35.61  ? 519  LEU A O   1 
ATOM   1668 C  CB  . LEU A 1 256 ? -7.498  -45.090 -32.859 0.50 36.86  ? 519  LEU A CB  1 
ATOM   1669 C  CG  . LEU A 1 256 ? -7.845  -44.229 -31.648 0.50 37.51  ? 519  LEU A CG  1 
ATOM   1670 C  CD1 . LEU A 1 256 ? -7.176  -44.774 -30.396 0.50 38.26  ? 519  LEU A CD1 1 
ATOM   1671 C  CD2 . LEU A 1 256 ? -7.453  -42.780 -31.881 0.50 38.04  ? 519  LEU A CD2 1 
ATOM   1672 N  N   . ARG A 1 257 ? -7.808  -46.381 -35.761 1.00 35.33  ? 520  ARG A N   1 
ATOM   1673 C  CA  . ARG A 1 257 ? -7.312  -47.193 -36.895 1.00 34.83  ? 520  ARG A CA  1 
ATOM   1674 C  C   . ARG A 1 257 ? -7.332  -46.366 -38.187 1.00 36.94  ? 520  ARG A C   1 
ATOM   1675 O  O   . ARG A 1 257 ? -6.346  -46.462 -38.952 1.00 37.50  ? 520  ARG A O   1 
ATOM   1676 C  CB  . ARG A 1 257 ? -8.019  -48.540 -36.999 1.00 34.41  ? 520  ARG A CB  1 
ATOM   1677 C  CG  . ARG A 1 257 ? -7.446  -49.405 -38.118 1.00 35.61  ? 520  ARG A CG  1 
ATOM   1678 C  CD  . ARG A 1 257 ? -8.183  -50.710 -38.254 1.00 35.33  ? 520  ARG A CD  1 
ATOM   1679 N  NE  . ARG A 1 257 ? -9.440  -50.529 -38.971 1.00 38.64  ? 520  ARG A NE  1 
ATOM   1680 C  CZ  . ARG A 1 257 ? -10.260 -51.497 -39.332 1.00 33.66  ? 520  ARG A CZ  1 
ATOM   1681 N  NH1 . ARG A 1 257 ? -10.003 -52.745 -39.034 1.00 35.68  ? 520  ARG A NH1 1 
ATOM   1682 N  NH2 . ARG A 1 257 ? -11.369 -51.204 -39.955 1.00 42.66  ? 520  ARG A NH2 1 
ATOM   1683 N  N   . ASP A 1 258 ? -8.372  -45.559 -38.430 0.50 36.74  ? 521  ASP A N   1 
ATOM   1684 C  CA  . ASP A 1 258 ? -8.457  -44.737 -39.674 0.50 38.48  ? 521  ASP A CA  1 
ATOM   1685 C  C   . ASP A 1 258 ? -7.402  -43.616 -39.624 0.50 36.42  ? 521  ASP A C   1 
ATOM   1686 O  O   . ASP A 1 258 ? -6.854  -43.281 -40.679 0.50 36.33  ? 521  ASP A O   1 
ATOM   1687 C  CB  . ASP A 1 258 ? -9.876  -44.227 -39.946 0.50 39.18  ? 521  ASP A CB  1 
ATOM   1688 C  CG  . ASP A 1 258 ? -10.742 -45.225 -40.707 0.50 42.27  ? 521  ASP A CG  1 
ATOM   1689 O  OD1 . ASP A 1 258 ? -10.304 -46.377 -40.870 0.50 44.04  ? 521  ASP A OD1 1 
ATOM   1690 O  OD2 . ASP A 1 258 ? -11.858 -44.848 -41.124 0.50 43.01  ? 521  ASP A OD2 1 
ATOM   1691 N  N   . VAL A 1 259 ? -7.125  -43.049 -38.451 1.00 34.55  ? 522  VAL A N   1 
ATOM   1692 C  CA  . VAL A 1 259 ? -6.018  -42.075 -38.298 1.00 37.90  ? 522  VAL A CA  1 
ATOM   1693 C  C   . VAL A 1 259 ? -4.687  -42.758 -38.654 1.00 38.73  ? 522  VAL A C   1 
ATOM   1694 O  O   . VAL A 1 259 ? -3.911  -42.175 -39.361 1.00 39.68  ? 522  VAL A O   1 
ATOM   1695 C  CB  . VAL A 1 259 ? -5.980  -41.488 -36.885 1.00 37.76  ? 522  VAL A CB  1 
ATOM   1696 C  CG1 . VAL A 1 259 ? -4.702  -40.706 -36.688 1.00 37.56  ? 522  VAL A CG1 1 
ATOM   1697 C  CG2 . VAL A 1 259 ? -7.216  -40.631 -36.636 1.00 38.54  ? 522  VAL A CG2 1 
ATOM   1698 N  N   . SER A 1 260 ? -4.468  -43.986 -38.173 0.50 39.88  ? 523  SER A N   1 
ATOM   1699 C  CA  . SER A 1 260 ? -3.259  -44.804 -38.463 0.50 40.42  ? 523  SER A CA  1 
ATOM   1700 C  C   . SER A 1 260 ? -3.042  -44.876 -39.979 0.50 40.36  ? 523  SER A C   1 
ATOM   1701 O  O   . SER A 1 260 ? -1.895  -44.700 -40.416 0.50 40.31  ? 523  SER A O   1 
ATOM   1702 C  CB  . SER A 1 260 ? -3.359  -46.184 -37.855 0.50 40.10  ? 523  SER A CB  1 
ATOM   1703 O  OG  . SER A 1 260 ? -3.916  -47.111 -38.780 0.50 39.88  ? 523  SER A OG  1 
ATOM   1704 N  N   . LYS A 1 261 ? -4.119  -45.082 -40.743 0.50 42.00  ? 524  LYS A N   1 
ATOM   1705 C  CA  . LYS A 1 261 ? -4.097  -45.252 -42.223 0.50 44.30  ? 524  LYS A CA  1 
ATOM   1706 C  C   . LYS A 1 261 ? -3.290  -44.121 -42.866 0.50 43.61  ? 524  LYS A C   1 
ATOM   1707 O  O   . LYS A 1 261 ? -2.662  -44.372 -43.904 0.50 45.55  ? 524  LYS A O   1 
ATOM   1708 C  CB  . LYS A 1 261 ? -5.515  -45.234 -42.803 0.50 45.56  ? 524  LYS A CB  1 
ATOM   1709 C  CG  . LYS A 1 261 ? -6.315  -46.516 -42.630 0.50 49.16  ? 524  LYS A CG  1 
ATOM   1710 C  CD  . LYS A 1 261 ? -7.661  -46.471 -43.326 0.50 50.40  ? 524  LYS A CD  1 
ATOM   1711 C  CE  . LYS A 1 261 ? -8.616  -47.553 -42.873 0.50 49.31  ? 524  LYS A CE  1 
ATOM   1712 N  NZ  . LYS A 1 261 ? -10.016 -47.212 -43.230 0.50 51.06  ? 524  LYS A NZ  1 
ATOM   1713 N  N   . LYS A 1 262 ? -3.339  -42.924 -42.273 0.50 44.62  ? 525  LYS A N   1 
ATOM   1714 C  CA  . LYS A 1 262 ? -2.741  -41.677 -42.819 0.50 46.17  ? 525  LYS A CA  1 
ATOM   1715 C  C   . LYS A 1 262 ? -1.214  -41.765 -42.797 0.50 45.18  ? 525  LYS A C   1 
ATOM   1716 O  O   . LYS A 1 262 ? -0.640  -42.007 -41.720 0.50 45.93  ? 525  LYS A O   1 
ATOM   1717 C  CB  . LYS A 1 262 ? -3.192  -40.458 -42.010 0.50 47.77  ? 525  LYS A CB  1 
ATOM   1718 C  CG  . LYS A 1 262 ? -4.683  -40.160 -42.073 0.50 48.62  ? 525  LYS A CG  1 
ATOM   1719 C  CD  . LYS A 1 262 ? -4.995  -38.694 -41.906 0.50 50.68  ? 525  LYS A CD  1 
ATOM   1720 C  CE  . LYS A 1 262 ? -6.120  -38.226 -42.803 0.50 53.52  ? 525  LYS A CE  1 
ATOM   1721 N  NZ  . LYS A 1 262 ? -5.875  -36.853 -43.307 0.50 53.52  ? 525  LYS A NZ  1 
ATOM   1722 N  N   . GLU A 1 263 ? -0.580  -41.551 -43.948 0.50 45.04  ? 526  GLU A N   1 
ATOM   1723 C  CA  . GLU A 1 263 ? 0.890   -41.364 -44.033 0.50 44.56  ? 526  GLU A CA  1 
ATOM   1724 C  C   . GLU A 1 263 ? 1.281   -40.298 -43.001 0.50 42.31  ? 526  GLU A C   1 
ATOM   1725 O  O   . GLU A 1 263 ? 0.554   -39.299 -42.882 0.50 42.07  ? 526  GLU A O   1 
ATOM   1726 C  CB  . GLU A 1 263 ? 1.295   -40.985 -45.458 0.50 47.01  ? 526  GLU A CB  1 
ATOM   1727 C  CG  . GLU A 1 263 ? 0.828   -41.985 -46.506 0.50 49.18  ? 526  GLU A CG  1 
ATOM   1728 C  CD  . GLU A 1 263 ? 1.366   -43.397 -46.337 0.50 50.92  ? 526  GLU A CD  1 
ATOM   1729 O  OE1 . GLU A 1 263 ? 2.441   -43.548 -45.725 0.50 50.23  ? 526  GLU A OE1 1 
ATOM   1730 O  OE2 . GLU A 1 263 ? 0.707   -44.344 -46.821 0.50 54.38  ? 526  GLU A OE2 1 
ATOM   1731 N  N   . GLY A 1 264 ? 2.371   -40.534 -42.270 1.00 39.44  ? 527  GLY A N   1 
ATOM   1732 C  CA  . GLY A 1 264 ? 2.874   -39.617 -41.232 1.00 44.16  ? 527  GLY A CA  1 
ATOM   1733 C  C   . GLY A 1 264 ? 3.838   -40.295 -40.292 1.00 40.09  ? 527  GLY A C   1 
ATOM   1734 O  O   . GLY A 1 264 ? 4.303   -41.373 -40.604 1.00 40.83  ? 527  GLY A O   1 
ATOM   1735 N  N   . GLY A 1 265 ? 4.080   -39.709 -39.134 1.00 41.58  ? 528  GLY A N   1 
ATOM   1736 C  CA  . GLY A 1 265 ? 5.044   -40.294 -38.189 1.00 43.31  ? 528  GLY A CA  1 
ATOM   1737 C  C   . GLY A 1 265 ? 4.334   -41.117 -37.131 1.00 49.55  ? 528  GLY A C   1 
ATOM   1738 O  O   . GLY A 1 265 ? 3.262   -41.662 -37.405 1.00 45.35  ? 528  GLY A O   1 
ATOM   1739 N  N   . ALA A 1 266 ? 4.905   -41.185 -35.938 1.00 41.00  ? 529  ALA A N   1 
ATOM   1740 C  CA  . ALA A 1 266 ? 4.331   -41.944 -34.828 1.00 36.80  ? 529  ALA A CA  1 
ATOM   1741 C  C   . ALA A 1 266 ? 3.001   -41.287 -34.460 1.00 36.92  ? 529  ALA A C   1 
ATOM   1742 O  O   . ALA A 1 266 ? 2.691   -40.177 -34.952 1.00 35.44  ? 529  ALA A O   1 
ATOM   1743 C  CB  . ALA A 1 266 ? 5.308   -41.932 -33.667 1.00 33.70  ? 529  ALA A CB  1 
ATOM   1744 N  N   . MET A 1 267 ? 2.228   -41.948 -33.597 0.50 35.84  ? 530  MET A N   1 
ATOM   1745 C  CA  . MET A 1 267 ? 0.978   -41.391 -33.022 0.50 36.61  ? 530  MET A CA  1 
ATOM   1746 C  C   . MET A 1 267 ? 1.299   -40.922 -31.596 0.50 33.04  ? 530  MET A C   1 
ATOM   1747 O  O   . MET A 1 267 ? 1.807   -41.734 -30.796 0.50 37.07  ? 530  MET A O   1 
ATOM   1748 C  CB  . MET A 1 267 ? -0.171  -42.414 -33.081 0.50 37.97  ? 530  MET A CB  1 
ATOM   1749 C  CG  . MET A 1 267 ? -0.586  -42.742 -34.531 0.50 41.67  ? 530  MET A CG  1 
ATOM   1750 S  SD  . MET A 1 267 ? -2.000  -43.880 -34.793 0.50 45.31  ? 530  MET A SD  1 
ATOM   1751 C  CE  . MET A 1 267 ? -2.956  -43.508 -33.328 0.50 43.78  ? 530  MET A CE  1 
ATOM   1752 N  N   . TYR A 1 268 ? 1.069   -39.637 -31.326 1.00 30.17  ? 531  TYR A N   1 
ATOM   1753 C  CA  . TYR A 1 268 ? 1.413   -38.961 -30.062 1.00 29.76  ? 531  TYR A CA  1 
ATOM   1754 C  C   . TYR A 1 268 ? 0.139   -38.793 -29.270 1.00 30.89  ? 531  TYR A C   1 
ATOM   1755 O  O   . TYR A 1 268 ? -0.922  -38.410 -29.841 1.00 32.92  ? 531  TYR A O   1 
ATOM   1756 C  CB  . TYR A 1 268 ? 2.118   -37.639 -30.360 1.00 29.90  ? 531  TYR A CB  1 
ATOM   1757 C  CG  . TYR A 1 268 ? 3.435   -37.831 -31.081 1.00 31.06  ? 531  TYR A CG  1 
ATOM   1758 C  CD1 . TYR A 1 268 ? 3.474   -37.987 -32.451 1.00 30.57  ? 531  TYR A CD1 1 
ATOM   1759 C  CD2 . TYR A 1 268 ? 4.628   -37.948 -30.378 1.00 32.37  ? 531  TYR A CD2 1 
ATOM   1760 C  CE1 . TYR A 1 268 ? 4.675   -38.157 -33.121 1.00 32.78  ? 531  TYR A CE1 1 
ATOM   1761 C  CE2 . TYR A 1 268 ? 5.827   -38.191 -31.025 1.00 33.45  ? 531  TYR A CE2 1 
ATOM   1762 C  CZ  . TYR A 1 268 ? 5.853   -38.274 -32.403 1.00 34.55  ? 531  TYR A CZ  1 
ATOM   1763 O  OH  . TYR A 1 268 ? 7.023   -38.518 -33.063 1.00 32.04  ? 531  TYR A OH  1 
ATOM   1764 N  N   . ALA A 1 269 ? 0.274   -39.042 -27.979 1.00 32.14  ? 532  ALA A N   1 
ATOM   1765 C  CA  . ALA A 1 269 ? -0.827  -39.001 -27.026 1.00 34.39  ? 532  ALA A CA  1 
ATOM   1766 C  C   . ALA A 1 269 ? -0.304  -38.435 -25.732 1.00 34.39  ? 532  ALA A C   1 
ATOM   1767 O  O   . ALA A 1 269 ? -0.389  -39.139 -24.721 1.00 36.22  ? 532  ALA A O   1 
ATOM   1768 C  CB  . ALA A 1 269 ? -1.437  -40.365 -26.835 1.00 35.24  ? 532  ALA A CB  1 
ATOM   1769 N  N   . ASP A 1 270 ? 0.069   -37.167 -25.745 1.00 32.80  ? 533  ASP A N   1 
ATOM   1770 C  CA  . ASP A 1 270 ? 0.536   -36.476 -24.521 1.00 33.94  ? 533  ASP A CA  1 
ATOM   1771 C  C   . ASP A 1 270 ? -0.666  -35.958 -23.755 1.00 40.36  ? 533  ASP A C   1 
ATOM   1772 O  O   . ASP A 1 270 ? -1.417  -35.166 -24.305 1.00 38.33  ? 533  ASP A O   1 
ATOM   1773 C  CB  . ASP A 1 270 ? 1.511   -35.357 -24.882 1.00 38.62  ? 533  ASP A CB  1 
ATOM   1774 C  CG  . ASP A 1 270 ? 2.745   -35.890 -25.603 1.00 40.70  ? 533  ASP A CG  1 
ATOM   1775 O  OD1 . ASP A 1 270 ? 3.064   -37.107 -25.394 1.00 37.82  ? 533  ASP A OD1 1 
ATOM   1776 O  OD2 . ASP A 1 270 ? 3.324   -35.134 -26.415 1.00 37.43  ? 533  ASP A OD2 1 
ATOM   1777 N  N   . ASP A 1 271 ? -0.694  -36.290 -22.472 1.00 42.39  ? 534  ASP A N   1 
ATOM   1778 C  CA  . ASP A 1 271 ? -1.719  -35.738 -21.567 1.00 44.20  ? 534  ASP A CA  1 
ATOM   1779 C  C   . ASP A 1 271 ? -1.179  -34.435 -20.992 1.00 43.34  ? 534  ASP A C   1 
ATOM   1780 O  O   . ASP A 1 271 ? 0.032   -34.353 -20.767 1.00 41.12  ? 534  ASP A O   1 
ATOM   1781 C  CB  . ASP A 1 271 ? -2.015  -36.708 -20.426 1.00 46.17  ? 534  ASP A CB  1 
ATOM   1782 C  CG  . ASP A 1 271 ? -3.083  -37.713 -20.782 1.00 47.14  ? 534  ASP A CG  1 
ATOM   1783 O  OD1 . ASP A 1 271 ? -3.984  -37.327 -21.530 1.00 43.93  ? 534  ASP A OD1 1 
ATOM   1784 O  OD2 . ASP A 1 271 ? -2.999  -38.855 -20.306 1.00 49.85  ? 534  ASP A OD2 1 
ATOM   1785 N  N   . THR A 1 272 ? -2.052  -33.459 -20.780 1.00 38.14  ? 535  THR A N   1 
ATOM   1786 C  CA  . THR A 1 272 ? -1.639  -32.199 -20.132 1.00 34.86  ? 535  THR A CA  1 
ATOM   1787 C  C   . THR A 1 272 ? -1.820  -32.375 -18.627 1.00 33.97  ? 535  THR A C   1 
ATOM   1788 O  O   . THR A 1 272 ? -2.733  -33.096 -18.239 1.00 43.03  ? 535  THR A O   1 
ATOM   1789 C  CB  . THR A 1 272 ? -2.428  -31.009 -20.686 1.00 34.81  ? 535  THR A CB  1 
ATOM   1790 O  OG1 . THR A 1 272 ? -2.286  -31.002 -22.105 1.00 42.95  ? 535  THR A OG1 1 
ATOM   1791 C  CG2 . THR A 1 272 ? -1.975  -29.683 -20.118 1.00 39.57  ? 535  THR A CG2 1 
ATOM   1792 N  N   . ALA A 1 273 ? -0.949  -31.772 -17.828 1.00 40.15  ? 536  ALA A N   1 
ATOM   1793 C  CA  . ALA A 1 273 ? -1.118  -31.801 -16.360 1.00 42.45  ? 536  ALA A CA  1 
ATOM   1794 C  C   . ALA A 1 273 ? -2.136  -30.737 -15.938 1.00 40.56  ? 536  ALA A C   1 
ATOM   1795 O  O   . ALA A 1 273 ? -1.887  -29.561 -16.202 1.00 46.20  ? 536  ALA A O   1 
ATOM   1796 C  CB  . ALA A 1 273 ? 0.213   -31.567 -15.716 1.00 42.59  ? 536  ALA A CB  1 
ATOM   1797 N  N   . GLY A 1 274 ? -3.244  -31.147 -15.323 1.00 44.84  ? 537  GLY A N   1 
ATOM   1798 C  CA  . GLY A 1 274 ? -4.294  -30.209 -14.872 1.00 43.89  ? 537  GLY A CA  1 
ATOM   1799 C  C   . GLY A 1 274 ? -4.768  -29.256 -15.954 1.00 43.68  ? 537  GLY A C   1 
ATOM   1800 O  O   . GLY A 1 274 ? -4.650  -28.050 -15.747 1.00 41.75  ? 537  GLY A O   1 
ATOM   1801 N  N   . TRP A 1 275 ? -5.320  -29.777 -17.048 1.00 39.26  ? 538  TRP A N   1 
ATOM   1802 C  CA  . TRP A 1 275 ? -5.749  -28.930 -18.193 1.00 39.94  ? 538  TRP A CA  1 
ATOM   1803 C  C   . TRP A 1 275 ? -6.635  -27.765 -17.735 1.00 37.05  ? 538  TRP A C   1 
ATOM   1804 O  O   . TRP A 1 275 ? -6.361  -26.643 -18.147 1.00 40.60  ? 538  TRP A O   1 
ATOM   1805 C  CB  . TRP A 1 275 ? -6.458  -29.788 -19.244 1.00 34.48  ? 538  TRP A CB  1 
ATOM   1806 C  CG  . TRP A 1 275 ? -7.111  -28.999 -20.334 1.00 33.16  ? 538  TRP A CG  1 
ATOM   1807 C  CD1 . TRP A 1 275 ? -8.327  -28.386 -20.287 1.00 32.68  ? 538  TRP A CD1 1 
ATOM   1808 C  CD2 . TRP A 1 275 ? -6.582  -28.742 -21.645 1.00 32.79  ? 538  TRP A CD2 1 
ATOM   1809 N  NE1 . TRP A 1 275 ? -8.587  -27.759 -21.473 1.00 34.84  ? 538  TRP A NE1 1 
ATOM   1810 C  CE2 . TRP A 1 275 ? -7.537  -27.961 -22.327 1.00 35.96  ? 538  TRP A CE2 1 
ATOM   1811 C  CE3 . TRP A 1 275 ? -5.401  -29.091 -22.307 1.00 34.09  ? 538  TRP A CE3 1 
ATOM   1812 C  CZ2 . TRP A 1 275 ? -7.344  -27.525 -23.636 1.00 35.95  ? 538  TRP A CZ2 1 
ATOM   1813 C  CZ3 . TRP A 1 275 ? -5.211  -28.658 -23.599 1.00 36.22  ? 538  TRP A CZ3 1 
ATOM   1814 C  CH2 . TRP A 1 275 ? -6.171  -27.889 -24.253 1.00 37.71  ? 538  TRP A CH2 1 
ATOM   1815 N  N   . ASP A 1 276 ? -7.642  -28.032 -16.909 1.00 40.81  ? 539  ASP A N   1 
ATOM   1816 C  CA  . ASP A 1 276 ? -8.597  -26.979 -16.466 1.00 44.73  ? 539  ASP A CA  1 
ATOM   1817 C  C   . ASP A 1 276 ? -7.845  -25.867 -15.727 1.00 48.36  ? 539  ASP A C   1 
ATOM   1818 O  O   . ASP A 1 276 ? -8.254  -24.709 -15.858 1.00 43.80  ? 539  ASP A O   1 
ATOM   1819 C  CB  . ASP A 1 276 ? -9.733  -27.576 -15.635 1.00 42.87  ? 539  ASP A CB  1 
ATOM   1820 C  CG  . ASP A 1 276 ? -10.718 -28.395 -16.450 1.00 49.53  ? 539  ASP A CG  1 
ATOM   1821 O  OD1 . ASP A 1 276 ? -10.631 -28.357 -17.687 1.00 48.60  ? 539  ASP A OD1 1 
ATOM   1822 O  OD2 . ASP A 1 276 ? -11.564 -29.063 -15.837 1.00 58.49  ? 539  ASP A OD2 1 
ATOM   1823 N  N   . THR A 1 277 ? -6.791  -26.219 -14.993 1.00 46.58  ? 540  THR A N   1 
ATOM   1824 C  CA  . THR A 1 277 ? -5.967  -25.224 -14.257 1.00 47.73  ? 540  THR A CA  1 
ATOM   1825 C  C   . THR A 1 277 ? -5.075  -24.443 -15.230 1.00 47.01  ? 540  THR A C   1 
ATOM   1826 O  O   . THR A 1 277 ? -4.601  -23.377 -14.832 1.00 51.63  ? 540  THR A O   1 
ATOM   1827 C  CB  . THR A 1 277 ? -5.159  -25.924 -13.159 1.00 52.26  ? 540  THR A CB  1 
ATOM   1828 O  OG1 . THR A 1 277 ? -4.166  -26.746 -13.770 1.00 56.93  ? 540  THR A OG1 1 
ATOM   1829 C  CG2 . THR A 1 277 ? -6.021  -26.759 -12.240 1.00 56.57  ? 540  THR A CG2 1 
ATOM   1830 N  N   . ARG A 1 278 ? -4.867  -24.950 -16.450 0.44 48.98  ? 541  ARG A N   1 
ATOM   1831 C  CA  . ARG A 1 278 ? -3.951  -24.306 -17.432 0.44 47.99  ? 541  ARG A CA  1 
ATOM   1832 C  C   . ARG A 1 278 ? -4.756  -23.479 -18.438 0.44 48.21  ? 541  ARG A C   1 
ATOM   1833 O  O   . ARG A 1 278 ? -4.154  -23.013 -19.418 0.44 46.88  ? 541  ARG A O   1 
ATOM   1834 C  CB  . ARG A 1 278 ? -3.145  -25.378 -18.166 0.44 51.65  ? 541  ARG A CB  1 
ATOM   1835 C  CG  . ARG A 1 278 ? -2.578  -26.466 -17.267 0.44 55.72  ? 541  ARG A CG  1 
ATOM   1836 C  CD  . ARG A 1 278 ? -1.323  -26.033 -16.537 0.44 59.68  ? 541  ARG A CD  1 
ATOM   1837 N  NE  . ARG A 1 278 ? -0.731  -27.136 -15.795 0.44 65.01  ? 541  ARG A NE  1 
ATOM   1838 C  CZ  . ARG A 1 278 ? 0.465   -27.100 -15.222 0.44 65.21  ? 541  ARG A CZ  1 
ATOM   1839 N  NH1 . ARG A 1 278 ? 1.209   -26.011 -15.315 0.44 66.32  ? 541  ARG A NH1 1 
ATOM   1840 N  NH2 . ARG A 1 278 ? 0.918   -28.153 -14.568 0.44 65.09  ? 541  ARG A NH2 1 
ATOM   1841 N  N   . ILE A 1 279 ? -6.063  -23.336 -18.217 0.44 46.50  ? 542  ILE A N   1 
ATOM   1842 C  CA  . ILE A 1 279 ? -6.953  -22.518 -19.092 0.44 47.63  ? 542  ILE A CA  1 
ATOM   1843 C  C   . ILE A 1 279 ? -6.681  -21.040 -18.794 0.44 48.08  ? 542  ILE A C   1 
ATOM   1844 O  O   . ILE A 1 279 ? -7.009  -20.582 -17.681 0.44 49.12  ? 542  ILE A O   1 
ATOM   1845 C  CB  . ILE A 1 279 ? -8.434  -22.903 -18.892 0.44 48.78  ? 542  ILE A CB  1 
ATOM   1846 C  CG1 . ILE A 1 279 ? -8.768  -24.209 -19.615 0.44 48.93  ? 542  ILE A CG1 1 
ATOM   1847 C  CG2 . ILE A 1 279 ? -9.357  -21.777 -19.327 0.44 48.07  ? 542  ILE A CG2 1 
ATOM   1848 C  CD1 . ILE A 1 279 ? -8.522  -24.153 -21.104 0.44 49.17  ? 542  ILE A CD1 1 
ATOM   1849 N  N   . THR A 1 280 ? -6.079  -20.336 -19.754 0.50 49.28  ? 543  THR A N   1 
ATOM   1850 C  CA  . THR A 1 280 ? -5.663  -18.917 -19.633 0.50 49.60  ? 543  THR A CA  1 
ATOM   1851 C  C   . THR A 1 280 ? -6.884  -18.019 -19.843 0.50 52.85  ? 543  THR A C   1 
ATOM   1852 O  O   . THR A 1 280 ? -7.977  -18.558 -20.105 0.50 48.40  ? 543  THR A O   1 
ATOM   1853 C  CB  . THR A 1 280 ? -4.571  -18.579 -20.652 0.50 48.12  ? 543  THR A CB  1 
ATOM   1854 O  OG1 . THR A 1 280 ? -5.182  -18.561 -21.939 0.50 48.13  ? 543  THR A OG1 1 
ATOM   1855 C  CG2 . THR A 1 280 ? -3.426  -19.568 -20.647 0.50 51.45  ? 543  THR A CG2 1 
ATOM   1856 N  N   . LEU A 1 281 ? -6.694  -16.702 -19.744 0.50 57.02  ? 544  LEU A N   1 
ATOM   1857 C  CA  . LEU A 1 281 ? -7.721  -15.693 -20.105 0.50 60.89  ? 544  LEU A CA  1 
ATOM   1858 C  C   . LEU A 1 281 ? -7.810  -15.630 -21.631 0.50 59.57  ? 544  LEU A C   1 
ATOM   1859 O  O   . LEU A 1 281 ? -8.933  -15.599 -22.154 0.50 60.63  ? 544  LEU A O   1 
ATOM   1860 C  CB  . LEU A 1 281 ? -7.337  -14.334 -19.510 0.50 65.63  ? 544  LEU A CB  1 
ATOM   1861 C  CG  . LEU A 1 281 ? -8.201  -13.156 -19.962 0.50 69.00  ? 544  LEU A CG  1 
ATOM   1862 C  CD1 . LEU A 1 281 ? -9.684  -13.462 -19.785 0.50 66.61  ? 544  LEU A CD1 1 
ATOM   1863 C  CD2 . LEU A 1 281 ? -7.819  -11.888 -19.212 0.50 70.66  ? 544  LEU A CD2 1 
ATOM   1864 N  N   . GLU A 1 282 ? -6.661  -15.647 -22.313 0.50 58.48  ? 545  GLU A N   1 
ATOM   1865 C  CA  . GLU A 1 282 ? -6.581  -15.513 -23.794 0.50 58.66  ? 545  GLU A CA  1 
ATOM   1866 C  C   . GLU A 1 282 ? -7.216  -16.752 -24.443 0.50 54.13  ? 545  GLU A C   1 
ATOM   1867 O  O   . GLU A 1 282 ? -7.761  -16.633 -25.562 0.50 52.23  ? 545  GLU A O   1 
ATOM   1868 C  CB  . GLU A 1 282 ? -5.133  -15.293 -24.230 0.50 62.15  ? 545  GLU A CB  1 
ATOM   1869 C  CG  . GLU A 1 282 ? -5.016  -14.503 -25.524 0.50 67.76  ? 545  GLU A CG  1 
ATOM   1870 C  CD  . GLU A 1 282 ? -5.546  -13.076 -25.478 0.50 70.07  ? 545  GLU A CD  1 
ATOM   1871 O  OE1 . GLU A 1 282 ? -5.959  -12.616 -24.384 0.50 64.28  ? 545  GLU A OE1 1 
ATOM   1872 O  OE2 . GLU A 1 282 ? -5.549  -12.421 -26.544 0.50 75.71  ? 545  GLU A OE2 1 
ATOM   1873 N  N   . ASP A 1 283 ? -7.157  -17.896 -23.760 0.50 49.43  ? 546  ASP A N   1 
ATOM   1874 C  CA  . ASP A 1 283 ? -7.931  -19.113 -24.127 0.50 48.36  ? 546  ASP A CA  1 
ATOM   1875 C  C   . ASP A 1 283 ? -9.426  -18.773 -24.051 0.50 46.05  ? 546  ASP A C   1 
ATOM   1876 O  O   . ASP A 1 283 ? -10.133 -18.959 -25.071 0.50 45.30  ? 546  ASP A O   1 
ATOM   1877 C  CB  . ASP A 1 283 ? -7.600  -20.293 -23.208 0.50 47.48  ? 546  ASP A CB  1 
ATOM   1878 C  CG  . ASP A 1 283 ? -6.309  -21.022 -23.546 0.50 47.31  ? 546  ASP A CG  1 
ATOM   1879 O  OD1 . ASP A 1 283 ? -5.819  -20.879 -24.691 0.50 46.47  ? 546  ASP A OD1 1 
ATOM   1880 O  OD2 . ASP A 1 283 ? -5.814  -21.745 -22.663 0.50 45.50  ? 546  ASP A OD2 1 
ATOM   1881 N  N   . LEU A 1 284 ? -9.874  -18.291 -22.885 1.00 41.35  ? 547  LEU A N   1 
ATOM   1882 C  CA  . LEU A 1 284 ? -11.307 -17.915 -22.622 1.00 45.15  ? 547  LEU A CA  1 
ATOM   1883 C  C   . LEU A 1 284 ? -11.824 -16.871 -23.632 1.00 46.67  ? 547  LEU A C   1 
ATOM   1884 O  O   . LEU A 1 284 ? -12.978 -16.957 -24.039 1.00 45.81  ? 547  LEU A O   1 
ATOM   1885 C  CB  . LEU A 1 284 ? -11.463 -17.402 -21.193 1.00 38.53  ? 547  LEU A CB  1 
ATOM   1886 C  CG  . LEU A 1 284 ? -11.173 -18.423 -20.099 1.00 39.82  ? 547  LEU A CG  1 
ATOM   1887 C  CD1 . LEU A 1 284 ? -11.104 -17.758 -18.741 1.00 44.06  ? 547  LEU A CD1 1 
ATOM   1888 C  CD2 . LEU A 1 284 ? -12.210 -19.533 -20.059 1.00 42.48  ? 547  LEU A CD2 1 
ATOM   1889 N  N   . LYS A 1 285 ? -10.960 -15.935 -24.039 0.50 48.91  ? 548  LYS A N   1 
ATOM   1890 C  CA  . LYS A 1 285 ? -11.282 -14.866 -25.020 0.50 49.35  ? 548  LYS A CA  1 
ATOM   1891 C  C   . LYS A 1 285 ? -11.344 -15.467 -26.430 0.50 47.95  ? 548  LYS A C   1 
ATOM   1892 O  O   . LYS A 1 285 ? -12.173 -14.999 -27.226 0.50 50.22  ? 548  LYS A O   1 
ATOM   1893 C  CB  . LYS A 1 285 ? -10.272 -13.717 -24.908 0.50 50.04  ? 548  LYS A CB  1 
ATOM   1894 C  CG  . LYS A 1 285 ? -10.353 -12.936 -23.600 0.50 50.84  ? 548  LYS A CG  1 
ATOM   1895 C  CD  . LYS A 1 285 ? -9.427  -11.735 -23.535 0.50 53.69  ? 548  LYS A CD  1 
ATOM   1896 C  CE  . LYS A 1 285 ? -9.593  -10.916 -22.269 0.50 55.07  ? 548  LYS A CE  1 
ATOM   1897 N  NZ  . LYS A 1 285 ? -8.518  -9.903  -22.117 0.50 56.42  ? 548  LYS A NZ  1 
ATOM   1898 N  N   . ASN A 1 286 ? -10.509 -16.464 -26.731 1.00 46.59  ? 549  ASN A N   1 
ATOM   1899 C  CA  . ASN A 1 286 ? -10.556 -17.150 -28.052 1.00 43.04  ? 549  ASN A CA  1 
ATOM   1900 C  C   . ASN A 1 286 ? -11.835 -18.011 -28.139 1.00 40.66  ? 549  ASN A C   1 
ATOM   1901 O  O   . ASN A 1 286 ? -12.397 -18.131 -29.235 1.00 40.15  ? 549  ASN A O   1 
ATOM   1902 C  CB  . ASN A 1 286 ? -9.246  -17.893 -28.306 1.00 47.70  ? 549  ASN A CB  1 
ATOM   1903 C  CG  . ASN A 1 286 ? -8.089  -16.953 -28.617 1.00 51.92  ? 549  ASN A CG  1 
ATOM   1904 O  OD1 . ASN A 1 286 ? -8.254  -15.900 -29.223 1.00 45.81  ? 549  ASN A OD1 1 
ATOM   1905 N  ND2 . ASN A 1 286 ? -6.886  -17.350 -28.267 1.00 53.56  ? 549  ASN A ND2 1 
ATOM   1906 N  N   . GLU A 1 287 ? -12.277 -18.597 -27.031 1.00 37.25  ? 550  GLU A N   1 
ATOM   1907 C  CA  . GLU A 1 287 ? -13.527 -19.418 -26.925 1.00 43.09  ? 550  GLU A CA  1 
ATOM   1908 C  C   . GLU A 1 287 ? -14.768 -18.520 -27.155 1.00 44.10  ? 550  GLU A C   1 
ATOM   1909 O  O   . GLU A 1 287 ? -15.697 -18.937 -27.900 1.00 39.61  ? 550  GLU A O   1 
ATOM   1910 C  CB  . GLU A 1 287 ? -13.552 -20.129 -25.568 1.00 35.30  ? 550  GLU A CB  1 
ATOM   1911 C  CG  . GLU A 1 287 ? -12.565 -21.263 -25.514 1.00 35.94  ? 550  GLU A CG  1 
ATOM   1912 C  CD  . GLU A 1 287 ? -12.248 -21.809 -24.148 1.00 42.65  ? 550  GLU A CD  1 
ATOM   1913 O  OE1 . GLU A 1 287 ? -12.867 -21.350 -23.181 1.00 49.67  ? 550  GLU A OE1 1 
ATOM   1914 O  OE2 . GLU A 1 287 ? -11.337 -22.685 -24.042 1.00 44.46  ? 550  GLU A OE2 1 
ATOM   1915 N  N   . GLU A 1 288 ? -14.753 -17.314 -26.577 0.50 44.50  ? 551  GLU A N   1 
ATOM   1916 C  CA  . GLU A 1 288 ? -15.833 -16.292 -26.663 0.50 46.49  ? 551  GLU A CA  1 
ATOM   1917 C  C   . GLU A 1 288 ? -16.105 -15.897 -28.122 0.50 45.00  ? 551  GLU A C   1 
ATOM   1918 O  O   . GLU A 1 288 ? -17.254 -15.525 -28.428 0.50 45.33  ? 551  GLU A O   1 
ATOM   1919 C  CB  . GLU A 1 288 ? -15.452 -15.052 -25.854 0.50 49.23  ? 551  GLU A CB  1 
ATOM   1920 C  CG  . GLU A 1 288 ? -16.631 -14.151 -25.525 0.50 53.11  ? 551  GLU A CG  1 
ATOM   1921 C  CD  . GLU A 1 288 ? -17.166 -13.302 -26.668 0.50 55.60  ? 551  GLU A CD  1 
ATOM   1922 O  OE1 . GLU A 1 288 ? -16.426 -13.105 -27.655 0.50 56.85  ? 551  GLU A OE1 1 
ATOM   1923 O  OE2 . GLU A 1 288 ? -18.329 -12.835 -26.565 0.50 57.21  ? 551  GLU A OE2 1 
ATOM   1924 N  N   . MET A 1 289 ? -15.107 -15.982 -29.001 0.50 43.60  ? 552  MET A N   1 
ATOM   1925 C  CA  . MET A 1 289 ? -15.269 -15.607 -30.433 0.50 44.69  ? 552  MET A CA  1 
ATOM   1926 C  C   . MET A 1 289 ? -16.384 -16.441 -31.081 0.50 43.90  ? 552  MET A C   1 
ATOM   1927 O  O   . MET A 1 289 ? -16.792 -16.084 -32.211 0.50 44.52  ? 552  MET A O   1 
ATOM   1928 C  CB  . MET A 1 289 ? -13.971 -15.785 -31.228 0.50 44.71  ? 552  MET A CB  1 
ATOM   1929 C  CG  . MET A 1 289 ? -13.038 -14.585 -31.133 0.50 47.21  ? 552  MET A CG  1 
ATOM   1930 S  SD  . MET A 1 289 ? -11.996 -14.357 -32.610 0.50 47.41  ? 552  MET A SD  1 
ATOM   1931 C  CE  . MET A 1 289 ? -11.146 -15.932 -32.658 0.50 47.48  ? 552  MET A CE  1 
ATOM   1932 N  N   . VAL A 1 290 ? -16.860 -17.512 -30.432 1.00 41.70  ? 553  VAL A N   1 
ATOM   1933 C  CA  . VAL A 1 290 ? -18.073 -18.240 -30.939 1.00 41.25  ? 553  VAL A CA  1 
ATOM   1934 C  C   . VAL A 1 290 ? -19.239 -17.232 -31.028 1.00 37.91  ? 553  VAL A C   1 
ATOM   1935 O  O   . VAL A 1 290 ? -19.994 -17.338 -32.003 1.00 40.72  ? 553  VAL A O   1 
ATOM   1936 C  CB  . VAL A 1 290 ? -18.499 -19.467 -30.116 1.00 36.65  ? 553  VAL A CB  1 
ATOM   1937 C  CG1 . VAL A 1 290 ? -18.962 -19.096 -28.721 1.00 36.95  ? 553  VAL A CG1 1 
ATOM   1938 C  CG2 . VAL A 1 290 ? -19.570 -20.269 -30.837 1.00 39.75  ? 553  VAL A CG2 1 
ATOM   1939 N  N   . THR A 1 291 ? -19.334 -16.252 -30.113 1.00 37.95  ? 554  THR A N   1 
ATOM   1940 C  CA  . THR A 1 291 ? -20.416 -15.220 -30.118 1.00 42.03  ? 554  THR A CA  1 
ATOM   1941 C  C   . THR A 1 291 ? -20.458 -14.404 -31.414 1.00 44.42  ? 554  THR A C   1 
ATOM   1942 O  O   . THR A 1 291 ? -21.559 -13.955 -31.810 1.00 46.21  ? 554  THR A O   1 
ATOM   1943 C  CB  . THR A 1 291 ? -20.343 -14.236 -28.965 1.00 39.63  ? 554  THR A CB  1 
ATOM   1944 O  OG1 . THR A 1 291 ? -19.090 -13.564 -29.075 1.00 40.11  ? 554  THR A OG1 1 
ATOM   1945 C  CG2 . THR A 1 291 ? -20.542 -14.923 -27.639 1.00 34.28  ? 554  THR A CG2 1 
ATOM   1946 N  N   . ASN A 1 292 ? -19.322 -14.254 -32.092 0.50 47.08  ? 555  ASN A N   1 
ATOM   1947 C  CA  . ASN A 1 292 ? -19.212 -13.479 -33.358 0.50 48.44  ? 555  ASN A CA  1 
ATOM   1948 C  C   . ASN A 1 292 ? -19.875 -14.258 -34.506 0.50 49.45  ? 555  ASN A C   1 
ATOM   1949 O  O   . ASN A 1 292 ? -19.817 -13.782 -35.663 0.50 50.79  ? 555  ASN A O   1 
ATOM   1950 C  CB  . ASN A 1 292 ? -17.752 -13.104 -33.617 0.50 49.77  ? 555  ASN A CB  1 
ATOM   1951 C  CG  . ASN A 1 292 ? -17.149 -12.413 -32.412 0.50 51.15  ? 555  ASN A CG  1 
ATOM   1952 O  OD1 . ASN A 1 292 ? -17.885 -11.956 -31.537 0.50 52.44  ? 555  ASN A OD1 1 
ATOM   1953 N  ND2 . ASN A 1 292 ? -15.828 -12.346 -32.346 0.50 51.11  ? 555  ASN A ND2 1 
ATOM   1954 N  N   . HIS A 1 293 ? -20.494 -15.405 -34.206 0.50 47.54  ? 556  HIS A N   1 
ATOM   1955 C  CA  . HIS A 1 293 ? -21.293 -16.199 -35.178 0.50 46.78  ? 556  HIS A CA  1 
ATOM   1956 C  C   . HIS A 1 293 ? -22.774 -16.198 -34.772 0.50 42.59  ? 556  HIS A C   1 
ATOM   1957 O  O   . HIS A 1 293 ? -23.567 -16.896 -35.433 0.50 40.79  ? 556  HIS A O   1 
ATOM   1958 C  CB  . HIS A 1 293 ? -20.682 -17.600 -35.315 0.50 46.61  ? 556  HIS A CB  1 
ATOM   1959 C  CG  . HIS A 1 293 ? -19.256 -17.541 -35.749 0.50 48.72  ? 556  HIS A CG  1 
ATOM   1960 N  ND1 . HIS A 1 293 ? -18.892 -17.563 -37.079 0.50 47.73  ? 556  HIS A ND1 1 
ATOM   1961 C  CD2 . HIS A 1 293 ? -18.113 -17.395 -35.042 0.50 48.41  ? 556  HIS A CD2 1 
ATOM   1962 C  CE1 . HIS A 1 293 ? -17.583 -17.455 -37.174 0.50 46.73  ? 556  HIS A CE1 1 
ATOM   1963 N  NE2 . HIS A 1 293 ? -17.082 -17.347 -35.939 0.50 47.60  ? 556  HIS A NE2 1 
ATOM   1964 N  N   . MET A 1 294 ? -23.115 -15.437 -33.729 1.00 41.09  ? 557  MET A N   1 
ATOM   1965 C  CA  . MET A 1 294 ? -24.473 -15.370 -33.150 1.00 46.82  ? 557  MET A CA  1 
ATOM   1966 C  C   . MET A 1 294 ? -25.104 -14.035 -33.561 1.00 51.73  ? 557  MET A C   1 
ATOM   1967 O  O   . MET A 1 294 ? -24.410 -13.174 -34.128 1.00 52.57  ? 557  MET A O   1 
ATOM   1968 C  CB  . MET A 1 294 ? -24.390 -15.458 -31.627 1.00 48.80  ? 557  MET A CB  1 
ATOM   1969 C  CG  . MET A 1 294 ? -23.704 -16.728 -31.121 1.00 48.35  ? 557  MET A CG  1 
ATOM   1970 S  SD  . MET A 1 294 ? -23.883 -16.865 -29.346 1.00 46.78  ? 557  MET A SD  1 
ATOM   1971 C  CE  . MET A 1 294 ? -22.956 -18.368 -29.083 1.00 56.16  ? 557  MET A CE  1 
ATOM   1972 N  N   . GLU A 1 295 ? -26.392 -13.867 -33.256 0.50 53.03  ? 558  GLU A N   1 
ATOM   1973 C  CA  . GLU A 1 295 ? -27.176 -12.648 -33.588 0.50 54.89  ? 558  GLU A CA  1 
ATOM   1974 C  C   . GLU A 1 295 ? -28.165 -12.339 -32.460 0.50 54.09  ? 558  GLU A C   1 
ATOM   1975 O  O   . GLU A 1 295 ? -28.494 -13.257 -31.679 0.50 53.28  ? 558  GLU A O   1 
ATOM   1976 C  CB  . GLU A 1 295 ? -27.913 -12.841 -34.914 0.50 55.60  ? 558  GLU A CB  1 
ATOM   1977 C  CG  . GLU A 1 295 ? -29.092 -13.790 -34.818 0.50 56.38  ? 558  GLU A CG  1 
ATOM   1978 C  CD  . GLU A 1 295 ? -30.004 -13.799 -36.034 0.50 59.02  ? 558  GLU A CD  1 
ATOM   1979 O  OE1 . GLU A 1 295 ? -29.506 -13.558 -37.159 0.50 59.61  ? 558  GLU A OE1 1 
ATOM   1980 O  OE2 . GLU A 1 295 ? -31.215 -14.047 -35.850 0.50 63.32  ? 558  GLU A OE2 1 
ATOM   1981 N  N   . GLY A 1 296 ? -28.601 -11.079 -32.386 0.50 57.19  ? 559  GLY A N   1 
ATOM   1982 C  CA  . GLY A 1 296 ? -29.706 -10.623 -31.522 0.50 54.51  ? 559  GLY A CA  1 
ATOM   1983 C  C   . GLY A 1 296 ? -29.461 -10.954 -30.063 0.50 52.84  ? 559  GLY A C   1 
ATOM   1984 O  O   . GLY A 1 296 ? -28.300 -10.862 -29.618 0.50 51.64  ? 559  GLY A O   1 
ATOM   1985 N  N   . GLU A 1 297 ? -30.526 -11.330 -29.354 0.50 52.04  ? 560  GLU A N   1 
ATOM   1986 C  CA  . GLU A 1 297 ? -30.522 -11.588 -27.894 0.50 53.36  ? 560  GLU A CA  1 
ATOM   1987 C  C   . GLU A 1 297 ? -29.498 -12.681 -27.565 0.50 54.04  ? 560  GLU A C   1 
ATOM   1988 O  O   . GLU A 1 297 ? -28.766 -12.521 -26.569 0.50 54.14  ? 560  GLU A O   1 
ATOM   1989 C  CB  . GLU A 1 297 ? -31.915 -12.014 -27.437 0.50 54.51  ? 560  GLU A CB  1 
ATOM   1990 C  CG  . GLU A 1 297 ? -32.113 -11.881 -25.941 0.50 56.64  ? 560  GLU A CG  1 
ATOM   1991 C  CD  . GLU A 1 297 ? -33.560 -12.003 -25.507 0.50 56.87  ? 560  GLU A CD  1 
ATOM   1992 O  OE1 . GLU A 1 297 ? -34.172 -13.048 -25.811 0.50 57.74  ? 560  GLU A OE1 1 
ATOM   1993 O  OE2 . GLU A 1 297 ? -34.072 -11.046 -24.886 0.50 58.63  ? 560  GLU A OE2 1 
ATOM   1994 N  N   . HIS A 1 298 ? -29.468 -13.754 -28.360 0.50 51.90  ? 561  HIS A N   1 
ATOM   1995 C  CA  . HIS A 1 298 ? -28.574 -14.921 -28.147 0.50 53.87  ? 561  HIS A CA  1 
ATOM   1996 C  C   . HIS A 1 298 ? -27.143 -14.400 -27.967 0.50 52.09  ? 561  HIS A C   1 
ATOM   1997 O  O   . HIS A 1 298 ? -26.561 -14.627 -26.889 0.50 51.39  ? 561  HIS A O   1 
ATOM   1998 C  CB  . HIS A 1 298 ? -28.724 -15.946 -29.282 0.50 53.07  ? 561  HIS A CB  1 
ATOM   1999 C  CG  . HIS A 1 298 ? -27.921 -17.187 -29.059 0.50 54.10  ? 561  HIS A CG  1 
ATOM   2000 N  ND1 . HIS A 1 298 ? -27.370 -17.913 -30.100 0.50 52.33  ? 561  HIS A ND1 1 
ATOM   2001 C  CD2 . HIS A 1 298 ? -27.557 -17.820 -27.923 0.50 50.62  ? 561  HIS A CD2 1 
ATOM   2002 C  CE1 . HIS A 1 298 ? -26.714 -18.945 -29.611 0.50 53.35  ? 561  HIS A CE1 1 
ATOM   2003 N  NE2 . HIS A 1 298 ? -26.814 -18.912 -28.279 0.50 51.61  ? 561  HIS A NE2 1 
ATOM   2004 N  N   . LYS A 1 299 ? -26.627 -13.677 -28.962 0.50 51.31  ? 562  LYS A N   1 
ATOM   2005 C  CA  . LYS A 1 299 ? -25.281 -13.056 -28.911 0.50 53.78  ? 562  LYS A CA  1 
ATOM   2006 C  C   . LYS A 1 299 ? -25.081 -12.441 -27.521 0.50 56.67  ? 562  LYS A C   1 
ATOM   2007 O  O   . LYS A 1 299 ? -24.113 -12.827 -26.835 0.50 56.35  ? 562  LYS A O   1 
ATOM   2008 C  CB  . LYS A 1 299 ? -25.122 -12.013 -30.018 0.50 52.92  ? 562  LYS A CB  1 
ATOM   2009 C  CG  . LYS A 1 299 ? -23.721 -11.430 -30.140 0.50 53.06  ? 562  LYS A CG  1 
ATOM   2010 C  CD  . LYS A 1 299 ? -23.611 -10.334 -31.171 0.50 55.19  ? 562  LYS A CD  1 
ATOM   2011 C  CE  . LYS A 1 299 ? -22.183 -9.924  -31.459 0.50 57.12  ? 562  LYS A CE  1 
ATOM   2012 N  NZ  . LYS A 1 299 ? -21.548 -10.833 -32.442 0.50 57.37  ? 562  LYS A NZ  1 
ATOM   2013 N  N   . LYS A 1 300 ? -25.982 -11.544 -27.110 0.50 59.68  ? 563  LYS A N   1 
ATOM   2014 C  CA  . LYS A 1 300 ? -25.867 -10.768 -25.844 0.50 63.18  ? 563  LYS A CA  1 
ATOM   2015 C  C   . LYS A 1 300 ? -25.829 -11.736 -24.658 0.50 56.41  ? 563  LYS A C   1 
ATOM   2016 O  O   . LYS A 1 300 ? -24.969 -11.560 -23.780 0.50 59.87  ? 563  LYS A O   1 
ATOM   2017 C  CB  . LYS A 1 300 ? -27.025 -9.772  -25.704 0.50 69.45  ? 563  LYS A CB  1 
ATOM   2018 C  CG  . LYS A 1 300 ? -27.107 -8.714  -26.797 0.50 73.97  ? 563  LYS A CG  1 
ATOM   2019 C  CD  . LYS A 1 300 ? -25.843 -7.889  -26.952 0.50 78.98  ? 563  LYS A CD  1 
ATOM   2020 C  CE  . LYS A 1 300 ? -25.978 -6.784  -27.981 0.50 85.75  ? 563  LYS A CE  1 
ATOM   2021 N  NZ  . LYS A 1 300 ? -24.756 -5.945  -28.062 0.50 87.56  ? 563  LYS A NZ  1 
ATOM   2022 N  N   . LEU A 1 301 ? -26.727 -12.722 -24.648 0.50 55.61  ? 564  LEU A N   1 
ATOM   2023 C  CA  . LEU A 1 301 ? -26.831 -13.744 -23.573 0.50 56.29  ? 564  LEU A CA  1 
ATOM   2024 C  C   . LEU A 1 301 ? -25.507 -14.522 -23.474 0.50 55.04  ? 564  LEU A C   1 
ATOM   2025 O  O   . LEU A 1 301 ? -24.948 -14.595 -22.360 0.50 51.64  ? 564  LEU A O   1 
ATOM   2026 C  CB  . LEU A 1 301 ? -28.019 -14.661 -23.881 0.50 56.93  ? 564  LEU A CB  1 
ATOM   2027 C  CG  . LEU A 1 301 ? -29.401 -14.023 -23.720 0.50 57.60  ? 564  LEU A CG  1 
ATOM   2028 C  CD1 . LEU A 1 301 ? -30.508 -15.018 -24.035 0.50 55.46  ? 564  LEU A CD1 1 
ATOM   2029 C  CD2 . LEU A 1 301 ? -29.587 -13.463 -22.315 0.50 57.52  ? 564  LEU A CD2 1 
ATOM   2030 N  N   . ALA A 1 302 ? -25.015 -15.063 -24.593 0.50 53.05  ? 565  ALA A N   1 
ATOM   2031 C  CA  . ALA A 1 302 ? -23.741 -15.817 -24.675 0.50 53.07  ? 565  ALA A CA  1 
ATOM   2032 C  C   . ALA A 1 302 ? -22.592 -14.928 -24.182 0.50 56.83  ? 565  ALA A C   1 
ATOM   2033 O  O   . ALA A 1 302 ? -21.774 -15.411 -23.380 0.50 60.47  ? 565  ALA A O   1 
ATOM   2034 C  CB  . ALA A 1 302 ? -23.506 -16.293 -26.087 0.50 50.52  ? 565  ALA A CB  1 
ATOM   2035 N  N   . GLU A 1 303 ? -22.546 -13.670 -24.633 0.50 56.27  ? 566  GLU A N   1 
ATOM   2036 C  CA  . GLU A 1 303 ? -21.505 -12.682 -24.245 0.50 55.57  ? 566  GLU A CA  1 
ATOM   2037 C  C   . GLU A 1 303 ? -21.506 -12.509 -22.722 0.50 52.09  ? 566  GLU A C   1 
ATOM   2038 O  O   . GLU A 1 303 ? -20.411 -12.362 -22.136 0.50 49.74  ? 566  GLU A O   1 
ATOM   2039 C  CB  . GLU A 1 303 ? -21.740 -11.350 -24.958 0.50 57.52  ? 566  GLU A CB  1 
ATOM   2040 C  CG  . GLU A 1 303 ? -21.335 -11.387 -26.420 0.50 61.75  ? 566  GLU A CG  1 
ATOM   2041 C  CD  . GLU A 1 303 ? -21.478 -10.071 -27.165 0.50 67.84  ? 566  GLU A CD  1 
ATOM   2042 O  OE1 . GLU A 1 303 ? -21.655 -9.032  -26.492 0.50 71.10  ? 566  GLU A OE1 1 
ATOM   2043 O  OE2 . GLU A 1 303 ? -21.407 -10.087 -28.420 0.50 70.37  ? 566  GLU A OE2 1 
ATOM   2044 N  N   . ALA A 1 304 ? -22.686 -12.518 -22.104 0.50 47.76  ? 567  ALA A N   1 
ATOM   2045 C  CA  . ALA A 1 304 ? -22.856 -12.318 -20.647 0.50 49.10  ? 567  ALA A CA  1 
ATOM   2046 C  C   . ALA A 1 304 ? -22.320 -13.544 -19.895 0.50 49.13  ? 567  ALA A C   1 
ATOM   2047 O  O   . ALA A 1 304 ? -21.652 -13.353 -18.864 0.50 46.75  ? 567  ALA A O   1 
ATOM   2048 C  CB  . ALA A 1 304 ? -24.304 -12.043 -20.324 0.50 48.99  ? 567  ALA A CB  1 
ATOM   2049 N  N   . ILE A 1 305 ? -22.605 -14.754 -20.388 1.00 49.39  ? 568  ILE A N   1 
ATOM   2050 C  CA  . ILE A 1 305 ? -22.066 -16.005 -19.780 1.00 50.77  ? 568  ILE A CA  1 
ATOM   2051 C  C   . ILE A 1 305 ? -20.529 -15.916 -19.792 1.00 51.20  ? 568  ILE A C   1 
ATOM   2052 O  O   . ILE A 1 305 ? -19.926 -16.055 -18.713 1.00 43.51  ? 568  ILE A O   1 
ATOM   2053 C  CB  . ILE A 1 305 ? -22.583 -17.261 -20.493 1.00 56.54  ? 568  ILE A CB  1 
ATOM   2054 C  CG1 . ILE A 1 305 ? -24.093 -17.432 -20.277 1.00 53.70  ? 568  ILE A CG1 1 
ATOM   2055 C  CG2 . ILE A 1 305 ? -21.789 -18.502 -20.044 1.00 54.40  ? 568  ILE A CG2 1 
ATOM   2056 C  CD1 . ILE A 1 305 ? -24.500 -17.470 -18.821 1.00 52.58  ? 568  ILE A CD1 1 
ATOM   2057 N  N   . PHE A 1 306 ? -19.935 -15.579 -20.940 1.00 49.79  ? 569  PHE A N   1 
ATOM   2058 C  CA  . PHE A 1 306 ? -18.461 -15.527 -21.138 1.00 52.64  ? 569  PHE A CA  1 
ATOM   2059 C  C   . PHE A 1 306 ? -17.854 -14.449 -20.229 1.00 58.58  ? 569  PHE A C   1 
ATOM   2060 O  O   . PHE A 1 306 ? -17.037 -14.856 -19.382 1.00 57.50  ? 569  PHE A O   1 
ATOM   2061 C  CB  . PHE A 1 306 ? -18.095 -15.350 -22.611 1.00 49.23  ? 569  PHE A CB  1 
ATOM   2062 C  CG  . PHE A 1 306 ? -18.097 -16.637 -23.397 1.00 47.52  ? 569  PHE A CG  1 
ATOM   2063 C  CD1 . PHE A 1 306 ? -17.190 -17.645 -23.112 1.00 48.24  ? 569  PHE A CD1 1 
ATOM   2064 C  CD2 . PHE A 1 306 ? -18.964 -16.826 -24.451 1.00 45.04  ? 569  PHE A CD2 1 
ATOM   2065 C  CE1 . PHE A 1 306 ? -17.187 -18.815 -23.850 1.00 46.59  ? 569  PHE A CE1 1 
ATOM   2066 C  CE2 . PHE A 1 306 ? -18.973 -18.009 -25.182 1.00 47.07  ? 569  PHE A CE2 1 
ATOM   2067 C  CZ  . PHE A 1 306 ? -18.083 -19.001 -24.876 1.00 50.42  ? 569  PHE A CZ  1 
ATOM   2068 N  N   . LYS A 1 307 ? -18.290 -13.180 -20.335 1.00 59.66  ? 570  LYS A N   1 
ATOM   2069 C  CA  . LYS A 1 307 ? -17.803 -12.028 -19.513 1.00 57.58  ? 570  LYS A CA  1 
ATOM   2070 C  C   . LYS A 1 307 ? -18.045 -12.268 -18.020 1.00 54.03  ? 570  LYS A C   1 
ATOM   2071 O  O   . LYS A 1 307 ? -17.113 -12.108 -17.246 1.00 53.09  ? 570  LYS A O   1 
ATOM   2072 C  CB  . LYS A 1 307 ? -18.487 -10.707 -19.887 1.00 63.64  ? 570  LYS A CB  1 
ATOM   2073 C  CG  . LYS A 1 307 ? -17.861 -9.969  -21.064 1.00 71.09  ? 570  LYS A CG  1 
ATOM   2074 C  CD  . LYS A 1 307 ? -18.598 -8.710  -21.499 1.00 80.06  ? 570  LYS A CD  1 
ATOM   2075 C  CE  . LYS A 1 307 ? -18.038 -8.112  -22.778 1.00 88.91  ? 570  LYS A CE  1 
ATOM   2076 N  NZ  . LYS A 1 307 ? -18.054 -9.082  -23.906 1.00 80.10  ? 570  LYS A NZ  1 
ATOM   2077 N  N   . LEU A 1 308 ? -19.245 -12.652 -17.611 1.00 51.24  ? 571  LEU A N   1 
ATOM   2078 C  CA  . LEU A 1 308 ? -19.625 -12.498 -16.186 1.00 53.66  ? 571  LEU A CA  1 
ATOM   2079 C  C   . LEU A 1 308 ? -19.431 -13.798 -15.408 1.00 53.01  ? 571  LEU A C   1 
ATOM   2080 O  O   . LEU A 1 308 ? -19.297 -13.704 -14.200 1.00 56.02  ? 571  LEU A O   1 
ATOM   2081 C  CB  . LEU A 1 308 ? -21.076 -11.997 -16.113 1.00 61.91  ? 571  LEU A CB  1 
ATOM   2082 C  CG  . LEU A 1 308 ? -21.389 -10.778 -16.996 1.00 64.61  ? 571  LEU A CG  1 
ATOM   2083 C  CD1 . LEU A 1 308 ? -22.889 -10.520 -17.081 1.00 67.86  ? 571  LEU A CD1 1 
ATOM   2084 C  CD2 . LEU A 1 308 ? -20.667 -9.541  -16.496 1.00 63.08  ? 571  LEU A CD2 1 
ATOM   2085 N  N   . THR A 1 309 ? -19.519 -14.974 -16.027 1.00 51.97  ? 572  THR A N   1 
ATOM   2086 C  CA  . THR A 1 309 ? -19.456 -16.259 -15.281 1.00 54.23  ? 572  THR A CA  1 
ATOM   2087 C  C   . THR A 1 309 ? -18.185 -17.060 -15.619 1.00 50.83  ? 572  THR A C   1 
ATOM   2088 O  O   . THR A 1 309 ? -17.871 -17.909 -14.821 1.00 52.09  ? 572  THR A O   1 
ATOM   2089 C  CB  . THR A 1 309 ? -20.724 -17.102 -15.472 1.00 57.13  ? 572  THR A CB  1 
ATOM   2090 O  OG1 . THR A 1 309 ? -20.829 -17.512 -16.836 1.00 50.63  ? 572  THR A OG1 1 
ATOM   2091 C  CG2 . THR A 1 309 ? -21.979 -16.349 -15.079 1.00 66.04  ? 572  THR A CG2 1 
ATOM   2092 N  N   . TYR A 1 310 ? -17.512 -16.842 -16.755 1.00 53.48  ? 573  TYR A N   1 
ATOM   2093 C  CA  . TYR A 1 310 ? -16.342 -17.659 -17.200 1.00 53.95  ? 573  TYR A CA  1 
ATOM   2094 C  C   . TYR A 1 310 ? -15.056 -16.830 -16.995 1.00 54.89  ? 573  TYR A C   1 
ATOM   2095 O  O   . TYR A 1 310 ? -14.164 -17.331 -16.306 1.00 59.40  ? 573  TYR A O   1 
ATOM   2096 C  CB  . TYR A 1 310 ? -16.507 -18.170 -18.645 1.00 45.76  ? 573  TYR A CB  1 
ATOM   2097 C  CG  . TYR A 1 310 ? -17.545 -19.253 -18.891 1.00 42.33  ? 573  TYR A CG  1 
ATOM   2098 C  CD1 . TYR A 1 310 ? -18.392 -19.712 -17.895 1.00 35.47  ? 573  TYR A CD1 1 
ATOM   2099 C  CD2 . TYR A 1 310 ? -17.748 -19.749 -20.172 1.00 41.84  ? 573  TYR A CD2 1 
ATOM   2100 C  CE1 . TYR A 1 310 ? -19.354 -20.672 -18.142 1.00 36.77  ? 573  TYR A CE1 1 
ATOM   2101 C  CE2 . TYR A 1 310 ? -18.737 -20.686 -20.447 1.00 38.48  ? 573  TYR A CE2 1 
ATOM   2102 C  CZ  . TYR A 1 310 ? -19.515 -21.174 -19.423 1.00 38.60  ? 573  TYR A CZ  1 
ATOM   2103 O  OH  . TYR A 1 310 ? -20.491 -22.083 -19.706 1.00 41.86  ? 573  TYR A OH  1 
ATOM   2104 N  N   . GLN A 1 311 ? -15.003 -15.601 -17.529 1.00 47.34  ? 574  GLN A N   1 
ATOM   2105 C  CA  . GLN A 1 311 ? -13.852 -14.666 -17.462 1.00 51.19  ? 574  GLN A CA  1 
ATOM   2106 C  C   . GLN A 1 311 ? -13.837 -13.870 -16.148 1.00 53.05  ? 574  GLN A C   1 
ATOM   2107 O  O   . GLN A 1 311 ? -12.864 -13.120 -15.915 1.00 53.18  ? 574  GLN A O   1 
ATOM   2108 C  CB  . GLN A 1 311 ? -13.870 -13.756 -18.677 1.00 47.86  ? 574  GLN A CB  1 
ATOM   2109 C  CG  . GLN A 1 311 ? -13.831 -14.534 -19.979 1.00 46.47  ? 574  GLN A CG  1 
ATOM   2110 C  CD  . GLN A 1 311 ? -13.941 -13.605 -21.155 1.00 45.09  ? 574  GLN A CD  1 
ATOM   2111 O  OE1 . GLN A 1 311 ? -14.082 -12.407 -20.990 1.00 61.23  ? 574  GLN A OE1 1 
ATOM   2112 N  NE2 . GLN A 1 311 ? -13.861 -14.142 -22.357 1.00 49.10  ? 574  GLN A NE2 1 
ATOM   2113 N  N   . ASN A 1 312 ? -14.849 -14.056 -15.288 0.50 56.13  ? 575  ASN A N   1 
ATOM   2114 C  CA  . ASN A 1 312 ? -14.928 -13.481 -13.912 0.50 57.45  ? 575  ASN A CA  1 
ATOM   2115 C  C   . ASN A 1 312 ? -15.792 -14.396 -13.032 0.50 56.68  ? 575  ASN A C   1 
ATOM   2116 O  O   . ASN A 1 312 ? -17.015 -14.387 -13.216 0.50 64.24  ? 575  ASN A O   1 
ATOM   2117 C  CB  . ASN A 1 312 ? -15.517 -12.064 -13.917 0.50 56.62  ? 575  ASN A CB  1 
ATOM   2118 C  CG  . ASN A 1 312 ? -14.715 -11.070 -14.731 0.50 57.29  ? 575  ASN A CG  1 
ATOM   2119 O  OD1 . ASN A 1 312 ? -13.678 -10.585 -14.284 0.50 59.51  ? 575  ASN A OD1 1 
ATOM   2120 N  ND2 . ASN A 1 312 ? -15.190 -10.749 -15.923 0.50 56.81  ? 575  ASN A ND2 1 
ATOM   2121 N  N   . LYS A 1 313 ? -15.191 -15.147 -12.104 0.50 55.69  ? 576  LYS A N   1 
ATOM   2122 C  CA  . LYS A 1 313 ? -15.877 -16.231 -11.346 0.50 56.95  ? 576  LYS A CA  1 
ATOM   2123 C  C   . LYS A 1 313 ? -15.908 -15.907 -9.848  0.50 59.15  ? 576  LYS A C   1 
ATOM   2124 O  O   . LYS A 1 313 ? -14.928 -15.326 -9.359  0.50 60.10  ? 576  LYS A O   1 
ATOM   2125 C  CB  . LYS A 1 313 ? -15.155 -17.572 -11.516 0.50 58.74  ? 576  LYS A CB  1 
ATOM   2126 C  CG  . LYS A 1 313 ? -14.515 -17.832 -12.874 0.50 58.93  ? 576  LYS A CG  1 
ATOM   2127 C  CD  . LYS A 1 313 ? -13.578 -19.030 -12.863 0.50 58.12  ? 576  LYS A CD  1 
ATOM   2128 C  CE  . LYS A 1 313 ? -12.691 -19.102 -14.085 0.50 56.02  ? 576  LYS A CE  1 
ATOM   2129 N  NZ  . LYS A 1 313 ? -12.201 -17.758 -14.479 0.50 57.77  ? 576  LYS A NZ  1 
ATOM   2130 N  N   . VAL A 1 314 ? -16.980 -16.311 -9.156  1.00 57.59  ? 577  VAL A N   1 
ATOM   2131 C  CA  . VAL A 1 314 ? -17.114 -16.174 -7.689  1.00 60.35  ? 577  VAL A CA  1 
ATOM   2132 C  C   . VAL A 1 314 ? -17.457 -17.574 -7.243  1.00 59.21  ? 577  VAL A C   1 
ATOM   2133 O  O   . VAL A 1 314 ? -18.390 -18.186 -7.818  1.00 52.96  ? 577  VAL A O   1 
ATOM   2134 C  CB  . VAL A 1 314 ? -18.192 -15.156 -7.276  1.00 68.02  ? 577  VAL A CB  1 
ATOM   2135 C  CG1 . VAL A 1 314 ? -18.469 -15.203 -5.773  1.00 65.87  ? 577  VAL A CG1 1 
ATOM   2136 C  CG2 . VAL A 1 314 ? -17.820 -13.754 -7.734  1.00 66.61  ? 577  VAL A CG2 1 
ATOM   2137 N  N   . VAL A 1 315 ? -16.727 -18.080 -6.245  0.44 60.78  ? 578  VAL A N   1 
ATOM   2138 C  CA  . VAL A 1 315 ? -16.810 -19.494 -5.774  0.44 61.56  ? 578  VAL A CA  1 
ATOM   2139 C  C   . VAL A 1 315 ? -16.933 -19.509 -4.249  0.44 62.74  ? 578  VAL A C   1 
ATOM   2140 O  O   . VAL A 1 315 ? -16.342 -18.627 -3.600  0.44 60.43  ? 578  VAL A O   1 
ATOM   2141 C  CB  . VAL A 1 315 ? -15.580 -20.299 -6.233  0.44 62.69  ? 578  VAL A CB  1 
ATOM   2142 C  CG1 . VAL A 1 315 ? -15.671 -21.752 -5.792  0.44 62.55  ? 578  VAL A CG1 1 
ATOM   2143 C  CG2 . VAL A 1 315 ? -15.368 -20.195 -7.737  0.44 62.82  ? 578  VAL A CG2 1 
ATOM   2144 N  N   . ARG A 1 316 ? -17.663 -20.489 -3.714  0.44 67.64  ? 579  ARG A N   1 
ATOM   2145 C  CA  . ARG A 1 316 ? -17.810 -20.723 -2.255  0.44 72.74  ? 579  ARG A CA  1 
ATOM   2146 C  C   . ARG A 1 316 ? -17.123 -22.048 -1.904  0.44 76.71  ? 579  ARG A C   1 
ATOM   2147 O  O   . ARG A 1 316 ? -17.599 -23.096 -2.381  0.44 77.84  ? 579  ARG A O   1 
ATOM   2148 C  CB  . ARG A 1 316 ? -19.289 -20.722 -1.862  0.44 75.20  ? 579  ARG A CB  1 
ATOM   2149 C  CG  . ARG A 1 316 ? -20.074 -21.927 -2.360  0.44 78.53  ? 579  ARG A CG  1 
ATOM   2150 C  CD  . ARG A 1 316 ? -21.523 -21.850 -1.917  0.44 81.72  ? 579  ARG A CD  1 
ATOM   2151 N  NE  . ARG A 1 316 ? -22.056 -20.505 -2.082  0.44 84.94  ? 579  ARG A NE  1 
ATOM   2152 C  CZ  . ARG A 1 316 ? -23.171 -20.061 -1.514  0.44 86.82  ? 579  ARG A CZ  1 
ATOM   2153 N  NH1 . ARG A 1 316 ? -23.570 -18.818 -1.726  0.44 87.49  ? 579  ARG A NH1 1 
ATOM   2154 N  NH2 . ARG A 1 316 ? -23.878 -20.859 -0.735  0.44 86.29  ? 579  ARG A NH2 1 
ATOM   2155 N  N   . VAL A 1 317 ? -16.054 -21.990 -1.100  1.00 80.70  ? 580  VAL A N   1 
ATOM   2156 C  CA  . VAL A 1 317 ? -15.200 -23.168 -0.761  1.00 82.99  ? 580  VAL A CA  1 
ATOM   2157 C  C   . VAL A 1 317 ? -15.301 -23.500 0.734   1.00 88.52  ? 580  VAL A C   1 
ATOM   2158 O  O   . VAL A 1 317 ? -15.126 -22.598 1.563   1.00 71.28  ? 580  VAL A O   1 
ATOM   2159 C  CB  . VAL A 1 317 ? -13.741 -22.863 -1.136  1.00 85.08  ? 580  VAL A CB  1 
ATOM   2160 C  CG1 . VAL A 1 317 ? -12.929 -24.140 -1.230  1.00 90.27  ? 580  VAL A CG1 1 
ATOM   2161 C  CG2 . VAL A 1 317 ? -13.641 -22.071 -2.428  1.00 86.00  ? 580  VAL A CG2 1 
ATOM   2162 N  N   . GLN A 1 318 ? -15.561 -24.774 1.050   0.50 94.31  ? 581  GLN A N   1 
ATOM   2163 C  CA  . GLN A 1 318 ? -15.599 -25.326 2.433   0.50 101.64 ? 581  GLN A CA  1 
ATOM   2164 C  C   . GLN A 1 318 ? -14.176 -25.384 3.003   0.50 104.13 ? 581  GLN A C   1 
ATOM   2165 O  O   . GLN A 1 318 ? -13.354 -26.129 2.435   0.50 108.04 ? 581  GLN A O   1 
ATOM   2166 C  CB  . GLN A 1 318 ? -16.218 -26.725 2.422   0.50 104.15 ? 581  GLN A CB  1 
ATOM   2167 C  CG  . GLN A 1 318 ? -17.705 -26.741 2.737   0.50 107.52 ? 581  GLN A CG  1 
ATOM   2168 C  CD  . GLN A 1 318 ? -17.961 -26.923 4.213   0.50 109.84 ? 581  GLN A CD  1 
ATOM   2169 O  OE1 . GLN A 1 318 ? -17.214 -27.605 4.911   0.50 110.72 ? 581  GLN A OE1 1 
ATOM   2170 N  NE2 . GLN A 1 318 ? -19.031 -26.315 4.699   0.50 111.95 ? 581  GLN A NE2 1 
ATOM   2171 N  N   . ARG A 1 319 ? -13.908 -24.637 4.082   1.00 106.47 ? 582  ARG A N   1 
ATOM   2172 C  CA  . ARG A 1 319 ? -12.587 -24.646 4.792   1.00 115.84 ? 582  ARG A CA  1 
ATOM   2173 C  C   . ARG A 1 319 ? -12.819 -25.044 6.257   1.00 127.99 ? 582  ARG A C   1 
ATOM   2174 O  O   . ARG A 1 319 ? -13.523 -24.328 6.965   1.00 120.26 ? 582  ARG A O   1 
ATOM   2175 C  CB  . ARG A 1 319 ? -11.891 -23.286 4.677   1.00 107.21 ? 582  ARG A CB  1 
ATOM   2176 C  CG  . ARG A 1 319 ? -10.505 -23.264 5.303   1.00 99.76  ? 582  ARG A CG  1 
ATOM   2177 C  CD  . ARG A 1 319 ? -9.551  -22.295 4.633   1.00 99.90  ? 582  ARG A CD  1 
ATOM   2178 N  NE  . ARG A 1 319 ? -9.984  -20.910 4.755   1.00 100.94 ? 582  ARG A NE  1 
ATOM   2179 C  CZ  . ARG A 1 319 ? -9.513  -20.019 5.625   1.00 109.97 ? 582  ARG A CZ  1 
ATOM   2180 N  NH1 . ARG A 1 319 ? -8.561  -20.344 6.484   1.00 114.55 ? 582  ARG A NH1 1 
ATOM   2181 N  NH2 . ARG A 1 319 ? -9.984  -18.784 5.622   1.00 118.99 ? 582  ARG A NH2 1 
ATOM   2182 N  N   . PRO A 1 320 ? -12.255 -26.178 6.743   0.50 135.01 ? 583  PRO A N   1 
ATOM   2183 C  CA  . PRO A 1 320 ? -12.526 -26.664 8.101   0.50 137.04 ? 583  PRO A CA  1 
ATOM   2184 C  C   . PRO A 1 320 ? -12.218 -25.664 9.228   0.50 137.06 ? 583  PRO A C   1 
ATOM   2185 O  O   . PRO A 1 320 ? -13.104 -25.383 10.019  0.50 138.76 ? 583  PRO A O   1 
ATOM   2186 C  CB  . PRO A 1 320 ? -11.594 -27.879 8.251   0.50 137.49 ? 583  PRO A CB  1 
ATOM   2187 C  CG  . PRO A 1 320 ? -11.334 -28.338 6.833   0.50 137.40 ? 583  PRO A CG  1 
ATOM   2188 C  CD  . PRO A 1 320 ? -11.346 -27.071 6.004   0.50 137.31 ? 583  PRO A CD  1 
ATOM   2189 N  N   . THR A 1 321 ? -10.978 -25.169 9.281   0.50 133.91 ? 584  THR A N   1 
ATOM   2190 C  CA  . THR A 1 321 ? -10.463 -24.257 10.339  0.50 132.53 ? 584  THR A CA  1 
ATOM   2191 C  C   . THR A 1 321 ? -11.617 -23.418 10.901  0.50 128.76 ? 584  THR A C   1 
ATOM   2192 O  O   . THR A 1 321 ? -11.641 -23.238 12.137  0.50 124.14 ? 584  THR A O   1 
ATOM   2193 C  CB  . THR A 1 321 ? -9.334  -23.375 9.793   0.50 134.18 ? 584  THR A CB  1 
ATOM   2194 O  OG1 . THR A 1 321 ? -9.841  -22.662 8.666   0.50 133.22 ? 584  THR A OG1 1 
ATOM   2195 C  CG2 . THR A 1 321 ? -8.109  -24.169 9.394   0.50 134.73 ? 584  THR A CG2 1 
ATOM   2196 N  N   . THR A 1 325 ? -15.343 -24.512 11.110  0.44 83.02  ? 588  THR A N   1 
ATOM   2197 C  CA  . THR A 1 325 ? -15.738 -24.595 9.677   0.44 86.30  ? 588  THR A CA  1 
ATOM   2198 C  C   . THR A 1 325 ? -16.209 -23.220 9.192   0.44 87.80  ? 588  THR A C   1 
ATOM   2199 O  O   . THR A 1 325 ? -17.068 -22.613 9.865   0.44 84.82  ? 588  THR A O   1 
ATOM   2200 C  CB  . THR A 1 325 ? -16.829 -25.651 9.455   0.44 85.31  ? 588  THR A CB  1 
ATOM   2201 O  OG1 . THR A 1 325 ? -16.219 -26.942 9.461   0.44 86.57  ? 588  THR A OG1 1 
ATOM   2202 C  CG2 . THR A 1 325 ? -17.575 -25.458 8.153   0.44 85.63  ? 588  THR A CG2 1 
ATOM   2203 N  N   . VAL A 1 326 ? -15.671 -22.757 8.060   0.44 90.49  ? 589  VAL A N   1 
ATOM   2204 C  CA  . VAL A 1 326 ? -16.089 -21.494 7.384   0.44 94.52  ? 589  VAL A CA  1 
ATOM   2205 C  C   . VAL A 1 326 ? -16.165 -21.743 5.873   0.44 97.68  ? 589  VAL A C   1 
ATOM   2206 O  O   . VAL A 1 326 ? -15.464 -22.651 5.381   0.44 100.52 ? 589  VAL A O   1 
ATOM   2207 C  CB  . VAL A 1 326 ? -15.135 -20.328 7.711   0.44 95.58  ? 589  VAL A CB  1 
ATOM   2208 C  CG1 . VAL A 1 326 ? -14.620 -20.407 9.140   0.44 96.71  ? 589  VAL A CG1 1 
ATOM   2209 C  CG2 . VAL A 1 326 ? -13.978 -20.248 6.726   0.44 96.14  ? 589  VAL A CG2 1 
ATOM   2210 N  N   . MET A 1 327 ? -16.997 -20.956 5.183   1.00 101.82 ? 590  MET A N   1 
ATOM   2211 C  CA  . MET A 1 327 ? -17.096 -20.921 3.696   1.00 93.63  ? 590  MET A CA  1 
ATOM   2212 C  C   . MET A 1 327 ? -16.393 -19.650 3.225   1.00 79.86  ? 590  MET A C   1 
ATOM   2213 O  O   . MET A 1 327 ? -16.743 -18.597 3.748   1.00 75.56  ? 590  MET A O   1 
ATOM   2214 C  CB  . MET A 1 327 ? -18.563 -20.871 3.259   1.00 93.04  ? 590  MET A CB  1 
ATOM   2215 C  CG  . MET A 1 327 ? -18.774 -21.090 1.785   1.00 87.22  ? 590  MET A CG  1 
ATOM   2216 S  SD  . MET A 1 327 ? -18.707 -22.832 1.335   1.00 93.61  ? 590  MET A SD  1 
ATOM   2217 C  CE  . MET A 1 327 ? -20.387 -23.380 1.645   1.00 87.45  ? 590  MET A CE  1 
ATOM   2218 N  N   . ASP A 1 328 ? -15.441 -19.756 2.292   1.00 84.02  ? 591  ASP A N   1 
ATOM   2219 C  CA  . ASP A 1 328 ? -14.610 -18.625 1.795   1.00 81.69  ? 591  ASP A CA  1 
ATOM   2220 C  C   . ASP A 1 328 ? -15.162 -18.152 0.452   1.00 75.98  ? 591  ASP A C   1 
ATOM   2221 O  O   . ASP A 1 328 ? -15.540 -18.991 -0.368  1.00 76.72  ? 591  ASP A O   1 
ATOM   2222 C  CB  . ASP A 1 328 ? -13.141 -19.025 1.652   1.00 87.24  ? 591  ASP A CB  1 
ATOM   2223 C  CG  . ASP A 1 328 ? -12.492 -19.391 2.976   1.00 94.21  ? 591  ASP A CG  1 
ATOM   2224 O  OD1 . ASP A 1 328 ? -12.342 -18.486 3.817   1.00 104.52 ? 591  ASP A OD1 1 
ATOM   2225 O  OD2 . ASP A 1 328 ? -12.183 -20.591 3.177   1.00 92.28  ? 591  ASP A OD2 1 
ATOM   2226 N  N   . ILE A 1 329 ? -15.190 -16.846 0.243   1.00 69.96  ? 592  ILE A N   1 
ATOM   2227 C  CA  . ILE A 1 329 ? -15.716 -16.247 -1.004  1.00 66.79  ? 592  ILE A CA  1 
ATOM   2228 C  C   . ILE A 1 329 ? -14.518 -15.655 -1.712  1.00 72.03  ? 592  ILE A C   1 
ATOM   2229 O  O   . ILE A 1 329 ? -13.983 -14.623 -1.261  1.00 72.07  ? 592  ILE A O   1 
ATOM   2230 C  CB  . ILE A 1 329 ? -16.844 -15.234 -0.749  1.00 67.67  ? 592  ILE A CB  1 
ATOM   2231 C  CG1 . ILE A 1 329 ? -18.042 -15.915 -0.078  1.00 69.68  ? 592  ILE A CG1 1 
ATOM   2232 C  CG2 . ILE A 1 329 ? -17.239 -14.524 -2.036  1.00 67.57  ? 592  ILE A CG2 1 
ATOM   2233 C  CD1 . ILE A 1 329 ? -18.502 -17.192 -0.746  1.00 65.65  ? 592  ILE A CD1 1 
ATOM   2234 N  N   . ILE A 1 330 ? -14.133 -16.356 -2.772  1.00 80.04  ? 593  ILE A N   1 
ATOM   2235 C  CA  . ILE A 1 330 ? -12.884 -16.139 -3.541  1.00 78.88  ? 593  ILE A CA  1 
ATOM   2236 C  C   . ILE A 1 330 ? -13.284 -15.939 -4.999  1.00 71.61  ? 593  ILE A C   1 
ATOM   2237 O  O   . ILE A 1 330 ? -14.335 -16.466 -5.399  1.00 70.76  ? 593  ILE A O   1 
ATOM   2238 C  CB  . ILE A 1 330 ? -11.930 -17.336 -3.344  1.00 85.51  ? 593  ILE A CB  1 
ATOM   2239 C  CG1 . ILE A 1 330 ? -12.635 -18.673 -3.604  1.00 80.23  ? 593  ILE A CG1 1 
ATOM   2240 C  CG2 . ILE A 1 330 ? -11.301 -17.289 -1.958  1.00 81.54  ? 593  ILE A CG2 1 
ATOM   2241 C  CD1 . ILE A 1 330 ? -11.710 -19.864 -3.661  1.00 81.71  ? 593  ILE A CD1 1 
ATOM   2242 N  N   . SER A 1 331 ? -12.466 -15.211 -5.745  1.00 62.21  ? 594  SER A N   1 
ATOM   2243 C  CA  . SER A 1 331 ? -12.698 -14.939 -7.172  1.00 62.86  ? 594  SER A CA  1 
ATOM   2244 C  C   . SER A 1 331 ? -11.409 -15.180 -7.960  1.00 67.04  ? 594  SER A C   1 
ATOM   2245 O  O   . SER A 1 331 ? -10.337 -15.259 -7.360  1.00 64.49  ? 594  SER A O   1 
ATOM   2246 C  CB  . SER A 1 331 ? -13.210 -13.542 -7.368  1.00 60.79  ? 594  SER A CB  1 
ATOM   2247 O  OG  . SER A 1 331 ? -12.130 -12.630 -7.569  1.00 60.44  ? 594  SER A OG  1 
ATOM   2248 N  N   . ARG A 1 332 ? -11.541 -15.297 -9.285  0.44 67.40  ? 595  ARG A N   1 
ATOM   2249 C  CA  . ARG A 1 332 ? -10.421 -15.524 -10.236 0.44 67.37  ? 595  ARG A CA  1 
ATOM   2250 C  C   . ARG A 1 332 ? -10.939 -15.360 -11.667 0.44 67.86  ? 595  ARG A C   1 
ATOM   2251 O  O   . ARG A 1 332 ? -12.099 -15.740 -11.916 0.44 68.83  ? 595  ARG A O   1 
ATOM   2252 C  CB  . ARG A 1 332 ? -9.818  -16.919 -10.046 0.44 67.07  ? 595  ARG A CB  1 
ATOM   2253 C  CG  . ARG A 1 332 ? -8.786  -17.283 -11.102 0.44 65.58  ? 595  ARG A CG  1 
ATOM   2254 C  CD  . ARG A 1 332 ? -7.770  -18.292 -10.607 0.44 67.05  ? 595  ARG A CD  1 
ATOM   2255 N  NE  . ARG A 1 332 ? -6.509  -18.167 -11.325 0.44 66.11  ? 595  ARG A NE  1 
ATOM   2256 C  CZ  . ARG A 1 332 ? -5.380  -18.766 -10.969 0.44 65.57  ? 595  ARG A CZ  1 
ATOM   2257 N  NH1 . ARG A 1 332 ? -5.356  -19.539 -9.898  0.44 66.76  ? 595  ARG A NH1 1 
ATOM   2258 N  NH2 . ARG A 1 332 ? -4.282  -18.589 -11.682 0.44 65.86  ? 595  ARG A NH2 1 
ATOM   2259 N  N   . ARG A 1 333 ? -10.102 -14.827 -12.562 0.44 69.01  ? 596  ARG A N   1 
ATOM   2260 C  CA  . ARG A 1 333 ? -10.452 -14.534 -13.979 0.44 72.71  ? 596  ARG A CA  1 
ATOM   2261 C  C   . ARG A 1 333 ? -9.937  -15.642 -14.906 0.44 73.41  ? 596  ARG A C   1 
ATOM   2262 O  O   . ARG A 1 333 ? -10.316 -15.627 -16.098 0.44 72.51  ? 596  ARG A O   1 
ATOM   2263 C  CB  . ARG A 1 333 ? -9.840  -13.203 -14.418 0.44 73.77  ? 596  ARG A CB  1 
ATOM   2264 C  CG  . ARG A 1 333 ? -10.444 -11.984 -13.739 0.44 76.83  ? 596  ARG A CG  1 
ATOM   2265 C  CD  . ARG A 1 333 ? -10.383 -10.785 -14.664 0.44 79.22  ? 596  ARG A CD  1 
ATOM   2266 N  NE  . ARG A 1 333 ? -11.050 -11.057 -15.932 0.44 80.83  ? 596  ARG A NE  1 
ATOM   2267 C  CZ  . ARG A 1 333 ? -10.819 -10.395 -17.060 0.44 83.95  ? 596  ARG A CZ  1 
ATOM   2268 N  NH1 . ARG A 1 333 ? -9.930  -9.416  -17.083 0.44 85.01  ? 596  ARG A NH1 1 
ATOM   2269 N  NH2 . ARG A 1 333 ? -11.471 -10.717 -18.163 0.44 85.51  ? 596  ARG A NH2 1 
ATOM   2270 N  N   . ASP A 1 334 ? -9.096  -16.544 -14.387 0.44 72.01  ? 597  ASP A N   1 
ATOM   2271 C  CA  . ASP A 1 334 ? -8.393  -17.591 -15.176 0.44 69.24  ? 597  ASP A CA  1 
ATOM   2272 C  C   . ASP A 1 334 ? -8.820  -18.976 -14.671 0.44 68.48  ? 597  ASP A C   1 
ATOM   2273 O  O   . ASP A 1 334 ? -9.272  -19.079 -13.507 0.44 71.15  ? 597  ASP A O   1 
ATOM   2274 C  CB  . ASP A 1 334 ? -6.874  -17.392 -15.127 0.44 69.11  ? 597  ASP A CB  1 
ATOM   2275 C  CG  . ASP A 1 334 ? -6.201  -17.984 -13.899 0.44 68.29  ? 597  ASP A CG  1 
ATOM   2276 O  OD1 . ASP A 1 334 ? -6.843  -18.003 -12.830 0.44 68.26  ? 597  ASP A OD1 1 
ATOM   2277 O  OD2 . ASP A 1 334 ? -5.037  -18.424 -14.023 0.44 66.78  ? 597  ASP A OD2 1 
ATOM   2278 N  N   . GLN A 1 335 ? -8.699  -19.991 -15.535 0.44 65.53  ? 598  GLN A N   1 
ATOM   2279 C  CA  . GLN A 1 335 ? -9.000  -21.418 -15.237 0.44 62.47  ? 598  GLN A CA  1 
ATOM   2280 C  C   . GLN A 1 335 ? -10.378 -21.781 -15.799 0.44 59.38  ? 598  GLN A C   1 
ATOM   2281 O  O   . GLN A 1 335 ? -11.198 -20.863 -16.013 0.44 58.22  ? 598  GLN A O   1 
ATOM   2282 C  CB  . GLN A 1 335 ? -8.929  -21.697 -13.734 0.44 62.53  ? 598  GLN A CB  1 
ATOM   2283 C  CG  . GLN A 1 335 ? -7.500  -21.837 -13.227 0.44 64.33  ? 598  GLN A CG  1 
ATOM   2284 C  CD  . GLN A 1 335 ? -7.406  -22.522 -11.885 0.44 64.27  ? 598  GLN A CD  1 
ATOM   2285 O  OE1 . GLN A 1 335 ? -8.333  -23.192 -11.432 0.44 64.54  ? 598  GLN A OE1 1 
ATOM   2286 N  NE2 . GLN A 1 335 ? -6.260  -22.372 -11.246 0.44 64.43  ? 598  GLN A NE2 1 
ATOM   2287 N  N   . ARG A 1 336 ? -10.602 -23.076 -16.037 0.44 57.06  ? 599  ARG A N   1 
ATOM   2288 C  CA  . ARG A 1 336 ? -11.874 -23.620 -16.573 0.44 55.30  ? 599  ARG A CA  1 
ATOM   2289 C  C   . ARG A 1 336 ? -12.924 -23.649 -15.461 0.44 57.08  ? 599  ARG A C   1 
ATOM   2290 O  O   . ARG A 1 336 ? -12.724 -24.379 -14.466 0.44 56.82  ? 599  ARG A O   1 
ATOM   2291 C  CB  . ARG A 1 336 ? -11.685 -25.024 -17.150 0.44 51.85  ? 599  ARG A CB  1 
ATOM   2292 C  CG  . ARG A 1 336 ? -12.962 -25.604 -17.737 0.44 46.78  ? 599  ARG A CG  1 
ATOM   2293 C  CD  . ARG A 1 336 ? -13.441 -24.745 -18.886 0.44 44.12  ? 599  ARG A CD  1 
ATOM   2294 N  NE  . ARG A 1 336 ? -12.699 -25.046 -20.097 0.44 41.54  ? 599  ARG A NE  1 
ATOM   2295 C  CZ  . ARG A 1 336 ? -12.581 -24.226 -21.128 0.44 41.76  ? 599  ARG A CZ  1 
ATOM   2296 N  NH1 . ARG A 1 336 ? -13.150 -23.034 -21.095 0.44 39.83  ? 599  ARG A NH1 1 
ATOM   2297 N  NH2 . ARG A 1 336 ? -11.894 -24.608 -22.191 0.44 43.80  ? 599  ARG A NH2 1 
ATOM   2298 N  N   . GLY A 1 337 ? -13.991 -22.866 -15.644 0.50 59.29  ? 600  GLY A N   1 
ATOM   2299 C  CA  . GLY A 1 337 ? -15.183 -22.824 -14.777 0.50 61.55  ? 600  GLY A CA  1 
ATOM   2300 C  C   . GLY A 1 337 ? -16.450 -22.717 -15.609 0.50 62.09  ? 600  GLY A C   1 
ATOM   2301 O  O   . GLY A 1 337 ? -16.664 -21.659 -16.226 0.50 61.04  ? 600  GLY A O   1 
ATOM   2302 N  N   . SER A 1 338 ? -17.247 -23.788 -15.632 0.50 63.76  ? 601  SER A N   1 
ATOM   2303 C  CA  . SER A 1 338 ? -18.473 -23.943 -16.455 0.50 60.88  ? 601  SER A CA  1 
ATOM   2304 C  C   . SER A 1 338 ? -19.090 -25.320 -16.194 0.50 63.24  ? 601  SER A C   1 
ATOM   2305 O  O   . SER A 1 338 ? -18.526 -26.081 -15.383 0.50 66.05  ? 601  SER A O   1 
ATOM   2306 C  CB  . SER A 1 338 ? -18.173 -23.740 -17.918 0.50 62.34  ? 601  SER A CB  1 
ATOM   2307 O  OG  . SER A 1 338 ? -17.252 -24.702 -18.404 0.50 63.41  ? 601  SER A OG  1 
ATOM   2308 N  N   . GLY A 1 339 ? -20.220 -25.618 -16.838 0.50 66.49  ? 602  GLY A N   1 
ATOM   2309 C  CA  . GLY A 1 339 ? -20.856 -26.945 -16.764 0.50 67.83  ? 602  GLY A CA  1 
ATOM   2310 C  C   . GLY A 1 339 ? -19.963 -27.991 -17.402 0.50 64.40  ? 602  GLY A C   1 
ATOM   2311 O  O   . GLY A 1 339 ? -19.258 -27.642 -18.359 0.50 62.19  ? 602  GLY A O   1 
ATOM   2312 N  N   . GLN A 1 340 ? -19.984 -29.223 -16.886 0.50 67.71  ? 603  GLN A N   1 
ATOM   2313 C  CA  . GLN A 1 340 ? -19.084 -30.325 -17.319 0.50 70.98  ? 603  GLN A CA  1 
ATOM   2314 C  C   . GLN A 1 340 ? -19.309 -30.623 -18.809 0.50 68.59  ? 603  GLN A C   1 
ATOM   2315 O  O   . GLN A 1 340 ? -18.411 -31.228 -19.423 0.50 71.24  ? 603  GLN A O   1 
ATOM   2316 C  CB  . GLN A 1 340 ? -19.316 -31.564 -16.451 0.50 76.19  ? 603  GLN A CB  1 
ATOM   2317 C  CG  . GLN A 1 340 ? -20.761 -32.043 -16.446 0.50 81.30  ? 603  GLN A CG  1 
ATOM   2318 C  CD  . GLN A 1 340 ? -20.943 -33.311 -15.646 0.50 82.75  ? 603  GLN A CD  1 
ATOM   2319 O  OE1 . GLN A 1 340 ? -22.039 -33.867 -15.564 0.50 87.54  ? 603  GLN A OE1 1 
ATOM   2320 N  NE2 . GLN A 1 340 ? -19.859 -33.776 -15.046 0.50 79.12  ? 603  GLN A NE2 1 
ATOM   2321 N  N   . VAL A 1 341 ? -20.456 -30.211 -19.364 0.50 63.97  ? 604  VAL A N   1 
ATOM   2322 C  CA  . VAL A 1 341 ? -20.829 -30.437 -20.794 0.50 61.62  ? 604  VAL A CA  1 
ATOM   2323 C  C   . VAL A 1 341 ? -20.316 -29.265 -21.644 0.50 59.15  ? 604  VAL A C   1 
ATOM   2324 O  O   . VAL A 1 341 ? -19.745 -29.532 -22.735 0.50 48.78  ? 604  VAL A O   1 
ATOM   2325 C  CB  . VAL A 1 341 ? -22.347 -30.631 -20.972 0.50 64.40  ? 604  VAL A CB  1 
ATOM   2326 C  CG1 . VAL A 1 341 ? -22.711 -30.796 -22.440 0.50 65.41  ? 604  VAL A CG1 1 
ATOM   2327 C  CG2 . VAL A 1 341 ? -22.873 -31.801 -20.153 0.50 63.38  ? 604  VAL A CG2 1 
ATOM   2328 N  N   . VAL A 1 342 ? -20.514 -28.020 -21.185 1.00 54.12  ? 605  VAL A N   1 
ATOM   2329 C  CA  . VAL A 1 342 ? -19.865 -26.846 -21.852 1.00 49.98  ? 605  VAL A CA  1 
ATOM   2330 C  C   . VAL A 1 342 ? -18.335 -26.950 -21.696 1.00 40.13  ? 605  VAL A C   1 
ATOM   2331 O  O   . VAL A 1 342 ? -17.598 -26.659 -22.654 1.00 39.91  ? 605  VAL A O   1 
ATOM   2332 C  CB  . VAL A 1 342 ? -20.449 -25.501 -21.422 1.00 50.81  ? 605  VAL A CB  1 
ATOM   2333 C  CG1 . VAL A 1 342 ? -19.677 -24.343 -22.037 1.00 47.66  ? 605  VAL A CG1 1 
ATOM   2334 C  CG2 . VAL A 1 342 ? -21.907 -25.431 -21.869 1.00 63.31  ? 605  VAL A CG2 1 
ATOM   2335 N  N   . THR A 1 343 ? -17.870 -27.388 -20.525 0.50 37.60  ? 606  THR A N   1 
ATOM   2336 C  CA  . THR A 1 343 ? -16.429 -27.612 -20.237 0.50 39.19  ? 606  THR A CA  1 
ATOM   2337 C  C   . THR A 1 343 ? -15.843 -28.578 -21.276 0.50 36.98  ? 606  THR A C   1 
ATOM   2338 O  O   . THR A 1 343 ? -14.752 -28.293 -21.782 0.50 39.24  ? 606  THR A O   1 
ATOM   2339 C  CB  . THR A 1 343 ? -16.222 -28.130 -18.812 0.50 40.05  ? 606  THR A CB  1 
ATOM   2340 O  OG1 . THR A 1 343 ? -16.551 -27.050 -17.942 0.50 41.61  ? 606  THR A OG1 1 
ATOM   2341 C  CG2 . THR A 1 343 ? -14.804 -28.589 -18.555 0.50 40.59  ? 606  THR A CG2 1 
ATOM   2342 N  N   . TYR A 1 344 ? -16.561 -29.658 -21.594 0.50 34.79  ? 607  TYR A N   1 
ATOM   2343 C  CA  . TYR A 1 344 ? -16.131 -30.685 -22.573 0.50 34.26  ? 607  TYR A CA  1 
ATOM   2344 C  C   . TYR A 1 344 ? -15.975 -30.055 -23.961 0.50 34.02  ? 607  TYR A C   1 
ATOM   2345 O  O   . TYR A 1 344 ? -14.939 -30.310 -24.611 0.50 37.01  ? 607  TYR A O   1 
ATOM   2346 C  CB  . TYR A 1 344 ? -17.105 -31.864 -22.628 0.50 34.60  ? 607  TYR A CB  1 
ATOM   2347 C  CG  . TYR A 1 344 ? -16.719 -32.895 -23.661 0.50 34.28  ? 607  TYR A CG  1 
ATOM   2348 C  CD1 . TYR A 1 344 ? -15.806 -33.898 -23.367 0.50 34.53  ? 607  TYR A CD1 1 
ATOM   2349 C  CD2 . TYR A 1 344 ? -17.214 -32.831 -24.950 0.50 34.11  ? 607  TYR A CD2 1 
ATOM   2350 C  CE1 . TYR A 1 344 ? -15.421 -34.827 -24.320 0.50 33.21  ? 607  TYR A CE1 1 
ATOM   2351 C  CE2 . TYR A 1 344 ? -16.851 -33.758 -25.911 0.50 34.93  ? 607  TYR A CE2 1 
ATOM   2352 C  CZ  . TYR A 1 344 ? -15.948 -34.756 -25.595 0.50 34.03  ? 607  TYR A CZ  1 
ATOM   2353 O  OH  . TYR A 1 344 ? -15.596 -35.668 -26.542 0.50 35.05  ? 607  TYR A OH  1 
ATOM   2354 N  N   . GLY A 1 345 ? -16.965 -29.274 -24.407 1.00 32.45  ? 608  GLY A N   1 
ATOM   2355 C  CA  . GLY A 1 345 ? -16.956 -28.701 -25.776 1.00 30.18  ? 608  GLY A CA  1 
ATOM   2356 C  C   . GLY A 1 345 ? -15.843 -27.682 -25.963 1.00 29.30  ? 608  GLY A C   1 
ATOM   2357 O  O   . GLY A 1 345 ? -15.205 -27.678 -27.017 1.00 33.43  ? 608  GLY A O   1 
ATOM   2358 N  N   . LEU A 1 346 ? -15.628 -26.827 -24.975 1.00 28.08  ? 609  LEU A N   1 
ATOM   2359 C  CA  . LEU A 1 346 ? -14.625 -25.736 -25.045 1.00 32.40  ? 609  LEU A CA  1 
ATOM   2360 C  C   . LEU A 1 346 ? -13.215 -26.331 -24.849 1.00 31.37  ? 609  LEU A C   1 
ATOM   2361 O  O   . LEU A 1 346 ? -12.312 -25.889 -25.599 1.00 31.31  ? 609  LEU A O   1 
ATOM   2362 C  CB  . LEU A 1 346 ? -14.962 -24.651 -24.007 1.00 33.90  ? 609  LEU A CB  1 
ATOM   2363 C  CG  . LEU A 1 346 ? -16.283 -23.896 -24.224 1.00 35.96  ? 609  LEU A CG  1 
ATOM   2364 C  CD1 . LEU A 1 346 ? -16.481 -22.812 -23.166 1.00 37.17  ? 609  LEU A CD1 1 
ATOM   2365 C  CD2 . LEU A 1 346 ? -16.342 -23.281 -25.617 1.00 37.51  ? 609  LEU A CD2 1 
ATOM   2366 N  N   . ASN A 1 347 ? -13.069 -27.353 -23.983 1.00 31.64  ? 610  ASN A N   1 
ATOM   2367 C  CA  . ASN A 1 347 ? -11.814 -28.158 -23.839 1.00 33.33  ? 610  ASN A CA  1 
ATOM   2368 C  C   . ASN A 1 347 ? -11.481 -28.774 -25.199 1.00 28.88  ? 610  ASN A C   1 
ATOM   2369 O  O   . ASN A 1 347 ? -10.388 -28.572 -25.680 1.00 30.97  ? 610  ASN A O   1 
ATOM   2370 C  CB  . ASN A 1 347 ? -11.911 -29.209 -22.738 1.00 28.22  ? 610  ASN A CB  1 
ATOM   2371 C  CG  . ASN A 1 347 ? -11.758 -28.608 -21.354 1.00 31.75  ? 610  ASN A CG  1 
ATOM   2372 O  OD1 . ASN A 1 347 ? -11.339 -27.470 -21.186 1.00 31.49  ? 610  ASN A OD1 1 
ATOM   2373 N  ND2 . ASN A 1 347 ? -12.059 -29.382 -20.325 1.00 35.92  ? 610  ASN A ND2 1 
ATOM   2374 N  N   . THR A 1 348 ? -12.436 -29.421 -25.864 1.00 28.71  ? 611  THR A N   1 
ATOM   2375 C  CA  . THR A 1 348 ? -12.190 -29.998 -27.210 1.00 28.22  ? 611  THR A CA  1 
ATOM   2376 C  C   . THR A 1 348 ? -11.692 -28.900 -28.171 1.00 32.10  ? 611  THR A C   1 
ATOM   2377 O  O   . THR A 1 348 ? -10.710 -29.146 -28.931 1.00 29.88  ? 611  THR A O   1 
ATOM   2378 C  CB  . THR A 1 348 ? -13.438 -30.682 -27.741 1.00 26.35  ? 611  THR A CB  1 
ATOM   2379 O  OG1 . THR A 1 348 ? -13.884 -31.631 -26.767 1.00 29.30  ? 611  THR A OG1 1 
ATOM   2380 C  CG2 . THR A 1 348 ? -13.216 -31.332 -29.082 1.00 25.15  ? 611  THR A CG2 1 
ATOM   2381 N  N   . PHE A 1 349 ? -12.376 -27.756 -28.196 1.00 33.34  ? 612  PHE A N   1 
ATOM   2382 C  CA  . PHE A 1 349 ? -12.091 -26.635 -29.133 1.00 34.24  ? 612  PHE A CA  1 
ATOM   2383 C  C   . PHE A 1 349 ? -10.646 -26.146 -28.923 1.00 32.63  ? 612  PHE A C   1 
ATOM   2384 O  O   . PHE A 1 349 ? -9.893  -25.970 -29.885 1.00 33.19  ? 612  PHE A O   1 
ATOM   2385 C  CB  . PHE A 1 349 ? -13.068 -25.478 -28.893 1.00 33.05  ? 612  PHE A CB  1 
ATOM   2386 C  CG  . PHE A 1 349 ? -12.779 -24.270 -29.740 1.00 31.09  ? 612  PHE A CG  1 
ATOM   2387 C  CD1 . PHE A 1 349 ? -13.262 -24.181 -31.031 1.00 34.14  ? 612  PHE A CD1 1 
ATOM   2388 C  CD2 . PHE A 1 349 ? -12.004 -23.241 -29.258 1.00 29.85  ? 612  PHE A CD2 1 
ATOM   2389 C  CE1 . PHE A 1 349 ? -12.978 -23.091 -31.837 1.00 32.24  ? 612  PHE A CE1 1 
ATOM   2390 C  CE2 . PHE A 1 349 ? -11.695 -22.163 -30.070 1.00 31.83  ? 612  PHE A CE2 1 
ATOM   2391 C  CZ  . PHE A 1 349 ? -12.182 -22.081 -31.353 1.00 32.33  ? 612  PHE A CZ  1 
ATOM   2392 N  N   . THR A 1 350 ? -10.294 -25.849 -27.686 1.00 30.85  ? 613  THR A N   1 
ATOM   2393 C  CA  . THR A 1 350 ? -9.004  -25.202 -27.336 1.00 38.12  ? 613  THR A CA  1 
ATOM   2394 C  C   . THR A 1 350 ? -7.872  -26.247 -27.482 1.00 37.23  ? 613  THR A C   1 
ATOM   2395 O  O   . THR A 1 350 ? -6.757  -25.869 -27.933 1.00 40.06  ? 613  THR A O   1 
ATOM   2396 C  CB  . THR A 1 350 ? -9.042  -24.595 -25.929 1.00 38.42  ? 613  THR A CB  1 
ATOM   2397 O  OG1 . THR A 1 350 ? -10.024 -23.557 -25.845 1.00 37.42  ? 613  THR A OG1 1 
ATOM   2398 C  CG2 . THR A 1 350 ? -7.687  -24.019 -25.567 1.00 42.98  ? 613  THR A CG2 1 
ATOM   2399 N  N   . ASN A 1 351 ? -8.171  -27.526 -27.230 1.00 34.17  ? 614  ASN A N   1 
ATOM   2400 C  CA  . ASN A 1 351 ? -7.234  -28.654 -27.488 1.00 35.46  ? 614  ASN A CA  1 
ATOM   2401 C  C   . ASN A 1 351 ? -7.046  -28.779 -29.003 1.00 33.45  ? 614  ASN A C   1 
ATOM   2402 O  O   . ASN A 1 351 ? -5.914  -28.922 -29.454 1.00 31.27  ? 614  ASN A O   1 
ATOM   2403 C  CB  . ASN A 1 351 ? -7.693  -29.966 -26.829 1.00 32.39  ? 614  ASN A CB  1 
ATOM   2404 C  CG  . ASN A 1 351 ? -6.544  -30.904 -26.498 1.00 38.37  ? 614  ASN A CG  1 
ATOM   2405 O  OD1 . ASN A 1 351 ? -5.355  -30.536 -26.653 1.00 34.76  ? 614  ASN A OD1 1 
ATOM   2406 N  ND2 . ASN A 1 351 ? -6.881  -32.092 -26.000 1.00 34.66  ? 614  ASN A ND2 1 
ATOM   2407 N  N   . MET A 1 352 ? -8.108  -28.710 -29.783 1.00 29.50  ? 615  MET A N   1 
ATOM   2408 C  CA  . MET A 1 352 ? -7.968  -28.795 -31.263 1.00 36.94  ? 615  MET A CA  1 
ATOM   2409 C  C   . MET A 1 352 ? -7.015  -27.667 -31.690 1.00 33.87  ? 615  MET A C   1 
ATOM   2410 O  O   . MET A 1 352 ? -6.130  -27.884 -32.505 1.00 32.95  ? 615  MET A O   1 
ATOM   2411 C  CB  . MET A 1 352 ? -9.311  -28.637 -32.004 1.00 33.66  ? 615  MET A CB  1 
ATOM   2412 C  CG  . MET A 1 352 ? -10.223 -29.831 -31.855 1.00 36.25  ? 615  MET A CG  1 
ATOM   2413 S  SD  . MET A 1 352 ? -11.888 -29.658 -32.611 1.00 37.64  ? 615  MET A SD  1 
ATOM   2414 C  CE  . MET A 1 352 ? -11.509 -29.278 -34.316 1.00 32.20  ? 615  MET A CE  1 
ATOM   2415 N  N   . GLU A 1 353 ? -7.227  -26.485 -31.144 1.00 32.83  ? 616  GLU A N   1 
ATOM   2416 C  CA  . GLU A 1 353 ? -6.463  -25.261 -31.507 1.00 35.29  ? 616  GLU A CA  1 
ATOM   2417 C  C   . GLU A 1 353 ? -4.965  -25.484 -31.167 1.00 35.23  ? 616  GLU A C   1 
ATOM   2418 O  O   . GLU A 1 353 ? -4.096  -25.289 -32.033 1.00 35.38  ? 616  GLU A O   1 
ATOM   2419 C  CB  . GLU A 1 353 ? -7.067  -24.108 -30.705 1.00 34.93  ? 616  GLU A CB  1 
ATOM   2420 C  CG  . GLU A 1 353 ? -6.485  -22.748 -31.033 1.00 41.58  ? 616  GLU A CG  1 
ATOM   2421 C  CD  . GLU A 1 353 ? -6.815  -21.712 -29.983 1.00 43.09  ? 616  GLU A CD  1 
ATOM   2422 O  OE1 . GLU A 1 353 ? -8.032  -21.350 -29.856 1.00 45.81  ? 616  GLU A OE1 1 
ATOM   2423 O  OE2 . GLU A 1 353 ? -5.889  -21.352 -29.243 1.00 35.49  ? 616  GLU A OE2 1 
ATOM   2424 N  N   . ALA A 1 354 ? -4.683  -25.835 -29.918 1.00 32.88  ? 617  ALA A N   1 
ATOM   2425 C  CA  . ALA A 1 354 ? -3.329  -26.105 -29.405 1.00 33.65  ? 617  ALA A CA  1 
ATOM   2426 C  C   . ALA A 1 354 ? -2.631  -27.167 -30.275 1.00 35.20  ? 617  ALA A C   1 
ATOM   2427 O  O   . ALA A 1 354 ? -1.472  -26.954 -30.650 1.00 36.00  ? 617  ALA A O   1 
ATOM   2428 C  CB  . ALA A 1 354 ? -3.443  -26.503 -27.968 1.00 34.44  ? 617  ALA A CB  1 
ATOM   2429 N  N   . GLN A 1 355 ? -3.302  -28.263 -30.613 1.00 31.12  ? 618  GLN A N   1 
ATOM   2430 C  CA  . GLN A 1 355 ? -2.660  -29.350 -31.385 1.00 31.55  ? 618  GLN A CA  1 
ATOM   2431 C  C   . GLN A 1 355 ? -2.432  -28.914 -32.841 1.00 31.91  ? 618  GLN A C   1 
ATOM   2432 O  O   . GLN A 1 355 ? -1.441  -29.394 -33.418 1.00 32.49  ? 618  GLN A O   1 
ATOM   2433 C  CB  . GLN A 1 355 ? -3.429  -30.660 -31.279 1.00 29.10  ? 618  GLN A CB  1 
ATOM   2434 C  CG  . GLN A 1 355 ? -3.704  -31.093 -29.850 1.00 29.94  ? 618  GLN A CG  1 
ATOM   2435 C  CD  . GLN A 1 355 ? -2.424  -31.279 -29.077 1.00 33.99  ? 618  GLN A CD  1 
ATOM   2436 O  OE1 . GLN A 1 355 ? -1.413  -31.737 -29.596 1.00 30.86  ? 618  GLN A OE1 1 
ATOM   2437 N  NE2 . GLN A 1 355 ? -2.487  -31.001 -27.795 1.00 34.16  ? 618  GLN A NE2 1 
ATOM   2438 N  N   . LEU A 1 356 ? -3.302  -28.122 -33.472 1.00 29.51  ? 619  LEU A N   1 
ATOM   2439 C  CA  . LEU A 1 356 ? -3.049  -27.590 -34.859 1.00 33.58  ? 619  LEU A CA  1 
ATOM   2440 C  C   . LEU A 1 356 ? -1.776  -26.713 -34.865 1.00 34.52  ? 619  LEU A C   1 
ATOM   2441 O  O   . LEU A 1 356 ? -1.045  -26.763 -35.816 1.00 36.34  ? 619  LEU A O   1 
ATOM   2442 C  CB  . LEU A 1 356 ? -4.195  -26.714 -35.366 1.00 35.55  ? 619  LEU A CB  1 
ATOM   2443 C  CG  . LEU A 1 356 ? -5.316  -27.402 -36.127 1.00 39.22  ? 619  LEU A CG  1 
ATOM   2444 C  CD1 . LEU A 1 356 ? -6.437  -26.413 -36.430 1.00 39.23  ? 619  LEU A CD1 1 
ATOM   2445 C  CD2 . LEU A 1 356 ? -4.813  -28.025 -37.402 1.00 42.01  ? 619  LEU A CD2 1 
ATOM   2446 N  N   . ILE A 1 357 ? -1.577  -25.936 -33.817 1.00 30.91  ? 620  ILE A N   1 
ATOM   2447 C  CA  . ILE A 1 357 ? -0.467  -24.979 -33.645 1.00 35.04  ? 620  ILE A CA  1 
ATOM   2448 C  C   . ILE A 1 357 ? 0.829   -25.757 -33.406 1.00 41.82  ? 620  ILE A C   1 
ATOM   2449 O  O   . ILE A 1 357 ? 1.803   -25.421 -34.093 1.00 37.33  ? 620  ILE A O   1 
ATOM   2450 C  CB  . ILE A 1 357 ? -0.805  -23.995 -32.522 1.00 32.71  ? 620  ILE A CB  1 
ATOM   2451 C  CG1 . ILE A 1 357 ? -1.894  -23.030 -33.010 1.00 35.57  ? 620  ILE A CG1 1 
ATOM   2452 C  CG2 . ILE A 1 357 ? 0.444   -23.257 -32.049 1.00 35.13  ? 620  ILE A CG2 1 
ATOM   2453 C  CD1 . ILE A 1 357 ? -2.389  -22.055 -31.958 1.00 36.57  ? 620  ILE A CD1 1 
ATOM   2454 N  N   . ARG A 1 358 ? 0.813   -26.770 -32.521 1.00 38.38  ? 621  ARG A N   1 
ATOM   2455 C  CA  . ARG A 1 358 ? 1.924   -27.736 -32.372 1.00 31.71  ? 621  ARG A CA  1 
ATOM   2456 C  C   . ARG A 1 358 ? 2.238   -28.396 -33.707 1.00 34.16  ? 621  ARG A C   1 
ATOM   2457 O  O   . ARG A 1 358 ? 3.443   -28.566 -34.007 1.00 34.41  ? 621  ARG A O   1 
ATOM   2458 C  CB  . ARG A 1 358 ? 1.646   -28.806 -31.328 1.00 34.17  ? 621  ARG A CB  1 
ATOM   2459 C  CG  . ARG A 1 358 ? 2.872   -29.654 -31.035 1.00 35.07  ? 621  ARG A CG  1 
ATOM   2460 C  CD  . ARG A 1 358 ? 2.753   -30.583 -29.838 1.00 36.17  ? 621  ARG A CD  1 
ATOM   2461 N  NE  . ARG A 1 358 ? 3.934   -31.458 -29.739 1.00 37.49  ? 621  ARG A NE  1 
ATOM   2462 C  CZ  . ARG A 1 358 ? 4.111   -32.442 -28.852 1.00 38.69  ? 621  ARG A CZ  1 
ATOM   2463 N  NH1 . ARG A 1 358 ? 3.152   -32.767 -27.999 1.00 34.98  ? 621  ARG A NH1 1 
ATOM   2464 N  NH2 . ARG A 1 358 ? 5.248   -33.129 -28.843 1.00 41.60  ? 621  ARG A NH2 1 
ATOM   2465 N  N   . GLN A 1 359 ? 1.240   -28.809 -34.482 1.00 31.96  ? 622  GLN A N   1 
ATOM   2466 C  CA  . GLN A 1 359 ? 1.507   -29.323 -35.847 1.00 32.67  ? 622  GLN A CA  1 
ATOM   2467 C  C   . GLN A 1 359 ? 2.155   -28.203 -36.700 1.00 41.45  ? 622  GLN A C   1 
ATOM   2468 O  O   . GLN A 1 359 ? 2.954   -28.536 -37.605 1.00 46.81  ? 622  GLN A O   1 
ATOM   2469 C  CB  . GLN A 1 359 ? 0.266   -29.856 -36.558 1.00 33.27  ? 622  GLN A CB  1 
ATOM   2470 C  CG  . GLN A 1 359 ? -0.263  -31.166 -36.017 1.00 35.62  ? 622  GLN A CG  1 
ATOM   2471 C  CD  . GLN A 1 359 ? -1.251  -31.802 -36.955 1.00 37.30  ? 622  GLN A CD  1 
ATOM   2472 O  OE1 . GLN A 1 359 ? -0.915  -32.347 -38.004 1.00 35.76  ? 622  GLN A OE1 1 
ATOM   2473 N  NE2 . GLN A 1 359 ? -2.504  -31.771 -36.546 1.00 37.14  ? 622  GLN A NE2 1 
ATOM   2474 N  N   . MET A 1 360 ? 1.795   -26.936 -36.510 1.00 39.36  ? 623  MET A N   1 
ATOM   2475 C  CA  . MET A 1 360 ? 2.343   -25.830 -37.352 1.00 45.28  ? 623  MET A CA  1 
ATOM   2476 C  C   . MET A 1 360 ? 3.853   -25.705 -37.067 1.00 41.10  ? 623  MET A C   1 
ATOM   2477 O  O   . MET A 1 360 ? 4.613   -25.664 -38.008 1.00 35.92  ? 623  MET A O   1 
ATOM   2478 C  CB  . MET A 1 360 ? 1.662   -24.493 -37.056 1.00 43.27  ? 623  MET A CB  1 
ATOM   2479 C  CG  . MET A 1 360 ? 0.417   -24.262 -37.870 1.00 50.09  ? 623  MET A CG  1 
ATOM   2480 S  SD  . MET A 1 360 ? -0.382  -22.798 -37.219 1.00 47.95  ? 623  MET A SD  1 
ATOM   2481 C  CE  . MET A 1 360 ? -2.100  -23.196 -37.526 1.00 52.16  ? 623  MET A CE  1 
ATOM   2482 N  N   . GLU A 1 361 ? 4.216   -25.695 -35.793 1.00 35.58  ? 624  GLU A N   1 
ATOM   2483 C  CA  . GLU A 1 361 ? 5.603   -25.638 -35.294 1.00 41.17  ? 624  GLU A CA  1 
ATOM   2484 C  C   . GLU A 1 361 ? 6.407   -26.804 -35.877 1.00 44.11  ? 624  GLU A C   1 
ATOM   2485 O  O   . GLU A 1 361 ? 7.472   -26.545 -36.426 1.00 44.67  ? 624  GLU A O   1 
ATOM   2486 C  CB  . GLU A 1 361 ? 5.579   -25.661 -33.768 1.00 40.41  ? 624  GLU A CB  1 
ATOM   2487 C  CG  . GLU A 1 361 ? 6.928   -25.343 -33.158 1.00 41.38  ? 624  GLU A CG  1 
ATOM   2488 C  CD  . GLU A 1 361 ? 6.907   -24.988 -31.680 1.00 45.34  ? 624  GLU A CD  1 
ATOM   2489 O  OE1 . GLU A 1 361 ? 7.998   -24.982 -31.035 1.00 45.94  ? 624  GLU A OE1 1 
ATOM   2490 O  OE2 . GLU A 1 361 ? 5.805   -24.704 -31.166 1.00 44.88  ? 624  GLU A OE2 1 
ATOM   2491 N  N   . GLY A 1 362 ? 5.920   -28.044 -35.799 1.00 37.67  ? 625  GLY A N   1 
ATOM   2492 C  CA  . GLY A 1 362 ? 6.627   -29.210 -36.368 1.00 42.19  ? 625  GLY A CA  1 
ATOM   2493 C  C   . GLY A 1 362 ? 6.907   -29.109 -37.872 1.00 41.95  ? 625  GLY A C   1 
ATOM   2494 O  O   . GLY A 1 362 ? 7.945   -29.631 -38.342 1.00 42.24  ? 625  GLY A O   1 
ATOM   2495 N  N   . GLU A 1 363 ? 5.994   -28.500 -38.635 0.50 40.37  ? 626  GLU A N   1 
ATOM   2496 C  CA  . GLU A 1 363 ? 6.023   -28.525 -40.123 0.50 42.27  ? 626  GLU A CA  1 
ATOM   2497 C  C   . GLU A 1 363 ? 6.839   -27.334 -40.660 0.50 44.01  ? 626  GLU A C   1 
ATOM   2498 O  O   . GLU A 1 363 ? 7.154   -27.336 -41.868 0.50 43.84  ? 626  GLU A O   1 
ATOM   2499 C  CB  . GLU A 1 363 ? 4.595   -28.572 -40.677 0.50 42.68  ? 626  GLU A CB  1 
ATOM   2500 C  CG  . GLU A 1 363 ? 4.041   -29.989 -40.767 0.50 41.37  ? 626  GLU A CG  1 
ATOM   2501 C  CD  . GLU A 1 363 ? 2.665   -30.135 -41.402 0.50 41.97  ? 626  GLU A CD  1 
ATOM   2502 O  OE1 . GLU A 1 363 ? 2.445   -29.539 -42.482 0.50 39.80  ? 626  GLU A OE1 1 
ATOM   2503 O  OE2 . GLU A 1 363 ? 1.811   -30.855 -40.821 0.50 37.90  ? 626  GLU A OE2 1 
ATOM   2504 N  N   . GLY A 1 364 ? 7.182   -26.366 -39.803 0.50 43.92  ? 627  GLY A N   1 
ATOM   2505 C  CA  . GLY A 1 364 ? 7.995   -25.189 -40.168 0.50 47.53  ? 627  GLY A CA  1 
ATOM   2506 C  C   . GLY A 1 364 ? 7.165   -24.097 -40.824 0.50 52.84  ? 627  GLY A C   1 
ATOM   2507 O  O   . GLY A 1 364 ? 7.582   -23.606 -41.904 0.50 54.10  ? 627  GLY A O   1 
ATOM   2508 N  N   . VAL A 1 365 ? 6.047   -23.721 -40.183 0.50 52.90  ? 628  VAL A N   1 
ATOM   2509 C  CA  . VAL A 1 365 ? 5.109   -22.645 -40.627 0.50 54.46  ? 628  VAL A CA  1 
ATOM   2510 C  C   . VAL A 1 365 ? 5.474   -21.330 -39.921 0.50 56.34  ? 628  VAL A C   1 
ATOM   2511 O  O   . VAL A 1 365 ? 5.143   -20.262 -40.465 0.50 57.52  ? 628  VAL A O   1 
ATOM   2512 C  CB  . VAL A 1 365 ? 3.643   -23.040 -40.357 0.50 54.43  ? 628  VAL A CB  1 
ATOM   2513 C  CG1 . VAL A 1 365 ? 2.669   -21.945 -40.766 0.50 54.86  ? 628  VAL A CG1 1 
ATOM   2514 C  CG2 . VAL A 1 365 ? 3.281   -24.349 -41.038 0.50 55.31  ? 628  VAL A CG2 1 
ATOM   2515 N  N   . PHE A 1 366 ? 6.127   -21.401 -38.756 0.50 56.31  ? 629  PHE A N   1 
ATOM   2516 C  CA  . PHE A 1 366 ? 6.565   -20.218 -37.967 0.50 59.17  ? 629  PHE A CA  1 
ATOM   2517 C  C   . PHE A 1 366 ? 7.842   -20.546 -37.179 0.50 63.02  ? 629  PHE A C   1 
ATOM   2518 O  O   . PHE A 1 366 ? 7.919   -21.601 -36.514 0.50 64.64  ? 629  PHE A O   1 
ATOM   2519 C  CB  . PHE A 1 366 ? 5.439   -19.735 -37.051 0.50 57.79  ? 629  PHE A CB  1 
ATOM   2520 C  CG  . PHE A 1 366 ? 5.200   -20.588 -35.833 0.50 56.45  ? 629  PHE A CG  1 
ATOM   2521 C  CD1 . PHE A 1 366 ? 5.962   -20.420 -34.688 0.50 56.92  ? 629  PHE A CD1 1 
ATOM   2522 C  CD2 . PHE A 1 366 ? 4.203   -21.548 -35.828 0.50 56.25  ? 629  PHE A CD2 1 
ATOM   2523 C  CE1 . PHE A 1 366 ? 5.736   -21.204 -33.567 0.50 59.05  ? 629  PHE A CE1 1 
ATOM   2524 C  CE2 . PHE A 1 366 ? 3.977   -22.329 -34.706 0.50 56.60  ? 629  PHE A CE2 1 
ATOM   2525 C  CZ  . PHE A 1 366 ? 4.742   -22.156 -33.578 0.50 58.15  ? 629  PHE A CZ  1 
ATOM   2526 N  N   . LYS A 1 367 ? 8.820   -19.639 -37.248 0.50 66.03  ? 630  LYS A N   1 
ATOM   2527 C  CA  . LYS A 1 367 ? 10.190  -19.827 -36.702 0.50 69.07  ? 630  LYS A CA  1 
ATOM   2528 C  C   . LYS A 1 367 ? 10.174  -19.627 -35.181 0.50 65.08  ? 630  LYS A C   1 
ATOM   2529 O  O   . LYS A 1 367 ? 10.834  -20.425 -34.486 0.50 67.65  ? 630  LYS A O   1 
ATOM   2530 C  CB  . LYS A 1 367 ? 11.167  -18.865 -37.388 0.50 76.35  ? 630  LYS A CB  1 
ATOM   2531 C  CG  . LYS A 1 367 ? 12.629  -19.010 -36.973 0.50 80.54  ? 630  LYS A CG  1 
ATOM   2532 C  CD  . LYS A 1 367 ? 13.553  -17.983 -37.605 0.50 80.90  ? 630  LYS A CD  1 
ATOM   2533 C  CE  . LYS A 1 367 ? 14.877  -17.849 -36.882 0.50 82.70  ? 630  LYS A CE  1 
ATOM   2534 N  NZ  . LYS A 1 367 ? 14.695  -17.379 -35.487 0.50 81.68  ? 630  LYS A NZ  1 
ATOM   2535 N  N   . SER A 1 368 ? 9.478   -18.600 -34.682 1.00 57.72  ? 631  SER A N   1 
ATOM   2536 C  CA  . SER A 1 368 ? 9.532   -18.307 -33.225 1.00 56.45  ? 631  SER A CA  1 
ATOM   2537 C  C   . SER A 1 368 ? 8.202   -17.791 -32.679 1.00 52.07  ? 631  SER A C   1 
ATOM   2538 O  O   . SER A 1 368 ? 7.486   -17.124 -33.428 1.00 59.75  ? 631  SER A O   1 
ATOM   2539 C  CB  . SER A 1 368 ? 10.625  -17.329 -32.913 1.00 64.78  ? 631  SER A CB  1 
ATOM   2540 O  OG  . SER A 1 368 ? 10.616  -16.988 -31.535 1.00 66.58  ? 631  SER A OG  1 
ATOM   2541 N  N   . ILE A 1 369 ? 7.932   -18.049 -31.400 0.50 51.69  ? 632  ILE A N   1 
ATOM   2542 C  CA  . ILE A 1 369 ? 6.652   -17.634 -30.762 0.50 56.34  ? 632  ILE A CA  1 
ATOM   2543 C  C   . ILE A 1 369 ? 6.821   -16.242 -30.154 0.50 59.83  ? 632  ILE A C   1 
ATOM   2544 O  O   . ILE A 1 369 ? 5.819   -15.688 -29.675 0.50 56.30  ? 632  ILE A O   1 
ATOM   2545 C  CB  . ILE A 1 369 ? 6.255   -18.654 -29.681 0.50 54.14  ? 632  ILE A CB  1 
ATOM   2546 C  CG1 . ILE A 1 369 ? 7.213   -18.603 -28.489 0.50 54.21  ? 632  ILE A CG1 1 
ATOM   2547 C  CG2 . ILE A 1 369 ? 6.153   -20.053 -30.267 0.50 55.79  ? 632  ILE A CG2 1 
ATOM   2548 C  CD1 . ILE A 1 369 ? 6.798   -19.474 -27.334 0.50 54.81  ? 632  ILE A CD1 1 
ATOM   2549 N  N   . GLN A 1 370 ? 8.045   -15.715 -30.152 0.50 64.09  ? 633  GLN A N   1 
ATOM   2550 C  CA  . GLN A 1 370 ? 8.295   -14.404 -29.500 0.50 68.09  ? 633  GLN A CA  1 
ATOM   2551 C  C   . GLN A 1 370 ? 7.461   -13.342 -30.216 0.50 67.59  ? 633  GLN A C   1 
ATOM   2552 O  O   . GLN A 1 370 ? 6.855   -12.501 -29.529 0.50 60.55  ? 633  GLN A O   1 
ATOM   2553 C  CB  . GLN A 1 370 ? 9.787   -14.075 -29.539 0.50 69.90  ? 633  GLN A CB  1 
ATOM   2554 C  CG  . GLN A 1 370 ? 10.250  -13.234 -28.359 0.50 74.28  ? 633  GLN A CG  1 
ATOM   2555 C  CD  . GLN A 1 370 ? 10.212  -14.009 -27.065 0.50 77.14  ? 633  GLN A CD  1 
ATOM   2556 O  OE1 . GLN A 1 370 ? 10.171  -15.236 -27.057 0.50 82.95  ? 633  GLN A OE1 1 
ATOM   2557 N  NE2 . GLN A 1 370 ? 10.232  -13.291 -25.954 0.50 76.09  ? 633  GLN A NE2 1 
ATOM   2558 N  N   . HIS A 1 371 ? 7.431   -13.400 -31.547 0.50 67.22  ? 634  HIS A N   1 
ATOM   2559 C  CA  . HIS A 1 371 ? 6.641   -12.431 -32.346 0.50 70.56  ? 634  HIS A CA  1 
ATOM   2560 C  C   . HIS A 1 371 ? 6.427   -13.012 -33.742 0.50 70.11  ? 634  HIS A C   1 
ATOM   2561 O  O   . HIS A 1 371 ? 7.309   -13.748 -34.215 0.50 67.63  ? 634  HIS A O   1 
ATOM   2562 C  CB  . HIS A 1 371 ? 7.349   -11.074 -32.394 0.50 78.25  ? 634  HIS A CB  1 
ATOM   2563 C  CG  . HIS A 1 371 ? 7.207   -10.366 -33.700 0.50 84.30  ? 634  HIS A CG  1 
ATOM   2564 N  ND1 . HIS A 1 371 ? 8.071   -10.587 -34.754 0.50 85.97  ? 634  HIS A ND1 1 
ATOM   2565 C  CD2 . HIS A 1 371 ? 6.314   -9.448  -34.126 0.50 87.77  ? 634  HIS A CD2 1 
ATOM   2566 C  CE1 . HIS A 1 371 ? 7.714   -9.836  -35.776 0.50 88.46  ? 634  HIS A CE1 1 
ATOM   2567 N  NE2 . HIS A 1 371 ? 6.640   -9.127  -35.415 0.50 90.49  ? 634  HIS A NE2 1 
ATOM   2568 N  N   . LEU A 1 372 ? 5.304   -12.675 -34.373 0.50 73.01  ? 635  LEU A N   1 
ATOM   2569 C  CA  . LEU A 1 372 ? 4.994   -13.243 -35.707 0.50 74.06  ? 635  LEU A CA  1 
ATOM   2570 C  C   . LEU A 1 372 ? 5.145   -12.153 -36.766 0.50 74.54  ? 635  LEU A C   1 
ATOM   2571 O  O   . LEU A 1 372 ? 4.596   -11.057 -36.568 0.50 76.11  ? 635  LEU A O   1 
ATOM   2572 C  CB  . LEU A 1 372 ? 3.570   -13.805 -35.691 0.50 76.75  ? 635  LEU A CB  1 
ATOM   2573 C  CG  . LEU A 1 372 ? 3.370   -15.103 -36.471 0.50 77.19  ? 635  LEU A CG  1 
ATOM   2574 C  CD1 . LEU A 1 372 ? 4.130   -16.244 -35.814 0.50 76.30  ? 635  LEU A CD1 1 
ATOM   2575 C  CD2 . LEU A 1 372 ? 1.893   -15.445 -36.579 0.50 78.71  ? 635  LEU A CD2 1 
ATOM   2576 N  N   . THR A 1 373 ? 5.864   -12.455 -37.845 0.50 75.59  ? 636  THR A N   1 
ATOM   2577 C  CA  . THR A 1 373 ? 6.009   -11.490 -38.958 0.50 76.73  ? 636  THR A CA  1 
ATOM   2578 C  C   . THR A 1 373 ? 4.699   -11.452 -39.743 0.50 78.72  ? 636  THR A C   1 
ATOM   2579 O  O   . THR A 1 373 ? 3.892   -12.377 -39.571 0.50 79.75  ? 636  THR A O   1 
ATOM   2580 C  CB  . THR A 1 373 ? 7.174   -11.897 -39.863 0.50 76.18  ? 636  THR A CB  1 
ATOM   2581 O  OG1 . THR A 1 373 ? 6.763   -13.027 -40.631 0.50 77.54  ? 636  THR A OG1 1 
ATOM   2582 C  CG2 . THR A 1 373 ? 8.428   -12.228 -39.085 0.50 76.16  ? 636  THR A CG2 1 
ATOM   2583 N  N   . VAL A 1 374 ? 4.502   -10.428 -40.572 0.56 81.99  ? 637  VAL A N   1 
ATOM   2584 C  CA  . VAL A 1 374 ? 3.287   -10.375 -41.436 0.56 87.73  ? 637  VAL A CA  1 
ATOM   2585 C  C   . VAL A 1 374 ? 3.342   -11.553 -42.412 0.56 89.51  ? 637  VAL A C   1 
ATOM   2586 O  O   . VAL A 1 374 ? 2.307   -12.218 -42.591 0.56 88.02  ? 637  VAL A O   1 
ATOM   2587 C  CB  . VAL A 1 374 ? 3.183   -9.030  -42.177 0.56 91.53  ? 637  VAL A CB  1 
ATOM   2588 C  CG1 . VAL A 1 374 ? 2.743   -7.910  -41.248 0.56 93.39  ? 637  VAL A CG1 1 
ATOM   2589 C  CG2 . VAL A 1 374 ? 4.482   -8.667  -42.879 0.56 92.82  ? 637  VAL A CG2 1 
ATOM   2590 N  N   . THR A 1 375 ? 4.522   -11.827 -42.965 0.56 87.78  ? 638  THR A N   1 
ATOM   2591 C  CA  . THR A 1 375 ? 4.674   -12.995 -43.863 0.56 88.81  ? 638  THR A CA  1 
ATOM   2592 C  C   . THR A 1 375 ? 4.305   -14.261 -43.085 0.56 86.63  ? 638  THR A C   1 
ATOM   2593 O  O   . THR A 1 375 ? 3.696   -15.163 -43.682 0.56 82.71  ? 638  THR A O   1 
ATOM   2594 C  CB  . THR A 1 375 ? 6.099   -13.066 -44.420 0.56 92.99  ? 638  THR A CB  1 
ATOM   2595 O  OG1 . THR A 1 375 ? 6.993   -13.221 -43.318 0.56 96.46  ? 638  THR A OG1 1 
ATOM   2596 C  CG2 . THR A 1 375 ? 6.478   -11.838 -45.218 0.56 94.77  ? 638  THR A CG2 1 
ATOM   2597 N  N   . GLU A 1 376 ? 4.670   -14.317 -41.802 1.00 80.52  ? 639  GLU A N   1 
ATOM   2598 C  CA  . GLU A 1 376 ? 4.370   -15.517 -40.974 1.00 77.70  ? 639  GLU A CA  1 
ATOM   2599 C  C   . GLU A 1 376 ? 2.857   -15.594 -40.735 1.00 69.29  ? 639  GLU A C   1 
ATOM   2600 O  O   . GLU A 1 376 ? 2.323   -16.703 -40.780 1.00 60.37  ? 639  GLU A O   1 
ATOM   2601 C  CB  . GLU A 1 376 ? 5.201   -15.523 -39.691 1.00 64.95  ? 639  GLU A CB  1 
ATOM   2602 C  CG  . GLU A 1 376 ? 6.548   -16.193 -39.877 1.00 65.72  ? 639  GLU A CG  1 
ATOM   2603 C  CD  . GLU A 1 376 ? 7.441   -16.201 -38.652 1.00 60.60  ? 639  GLU A CD  1 
ATOM   2604 O  OE1 . GLU A 1 376 ? 8.380   -17.011 -38.620 1.00 71.15  ? 639  GLU A OE1 1 
ATOM   2605 O  OE2 . GLU A 1 376 ? 7.200   -15.391 -37.742 1.00 62.54  ? 639  GLU A OE2 1 
ATOM   2606 N  N   . GLU A 1 377 ? 2.195   -14.454 -40.550 1.00 63.61  ? 640  GLU A N   1 
ATOM   2607 C  CA  . GLU A 1 377 ? 0.717   -14.470 -40.404 1.00 69.73  ? 640  GLU A CA  1 
ATOM   2608 C  C   . GLU A 1 377 ? 0.086   -15.009 -41.691 1.00 69.70  ? 640  GLU A C   1 
ATOM   2609 O  O   . GLU A 1 377 ? -0.740  -15.921 -41.592 1.00 70.45  ? 640  GLU A O   1 
ATOM   2610 C  CB  . GLU A 1 377 ? 0.173   -13.091 -40.041 1.00 71.71  ? 640  GLU A CB  1 
ATOM   2611 C  CG  . GLU A 1 377 ? 0.664   -12.581 -38.700 1.00 80.01  ? 640  GLU A CG  1 
ATOM   2612 C  CD  . GLU A 1 377 ? 0.117   -11.216 -38.325 1.00 80.69  ? 640  GLU A CD  1 
ATOM   2613 O  OE1 . GLU A 1 377 ? -0.723  -10.697 -39.080 1.00 82.70  ? 640  GLU A OE1 1 
ATOM   2614 O  OE2 . GLU A 1 377 ? 0.534   -10.675 -37.283 1.00 79.44  ? 640  GLU A OE2 1 
ATOM   2615 N  N   . ILE A 1 378 ? 0.473   -14.485 -42.852 0.50 70.76  ? 641  ILE A N   1 
ATOM   2616 C  CA  . ILE A 1 378 ? -0.202  -14.940 -44.102 0.50 73.15  ? 641  ILE A CA  1 
ATOM   2617 C  C   . ILE A 1 378 ? 0.079   -16.436 -44.261 0.50 67.99  ? 641  ILE A C   1 
ATOM   2618 O  O   . ILE A 1 378 ? -0.809  -17.151 -44.749 0.50 67.74  ? 641  ILE A O   1 
ATOM   2619 C  CB  . ILE A 1 378 ? 0.251   -14.122 -45.329 0.50 74.80  ? 641  ILE A CB  1 
ATOM   2620 C  CG1 . ILE A 1 378 ? -0.493  -14.554 -46.595 0.50 77.99  ? 641  ILE A CG1 1 
ATOM   2621 C  CG2 . ILE A 1 378 ? 1.755   -14.193 -45.516 0.50 77.34  ? 641  ILE A CG2 1 
ATOM   2622 C  CD1 . ILE A 1 378 ? 0.029   -13.921 -47.862 0.50 81.09  ? 641  ILE A CD1 1 
ATOM   2623 N  N   . ALA A 1 379 ? 1.263   -16.882 -43.843 1.00 64.78  ? 642  ALA A N   1 
ATOM   2624 C  CA  . ALA A 1 379 ? 1.658   -18.303 -43.980 1.00 60.96  ? 642  ALA A CA  1 
ATOM   2625 C  C   . ALA A 1 379 ? 0.769   -19.202 -43.115 1.00 51.21  ? 642  ALA A C   1 
ATOM   2626 O  O   . ALA A 1 379 ? 0.325   -20.237 -43.617 1.00 43.66  ? 642  ALA A O   1 
ATOM   2627 C  CB  . ALA A 1 379 ? 3.102   -18.440 -43.593 1.00 55.87  ? 642  ALA A CB  1 
ATOM   2628 N  N   . VAL A 1 380 ? 0.538   -18.806 -41.866 1.00 44.32  ? 643  VAL A N   1 
ATOM   2629 C  CA  . VAL A 1 380 ? -0.340  -19.580 -40.950 1.00 48.45  ? 643  VAL A CA  1 
ATOM   2630 C  C   . VAL A 1 380 ? -1.742  -19.621 -41.566 1.00 57.84  ? 643  VAL A C   1 
ATOM   2631 O  O   . VAL A 1 380 ? -2.349  -20.702 -41.592 1.00 45.46  ? 643  VAL A O   1 
ATOM   2632 C  CB  . VAL A 1 380 ? -0.331  -18.956 -39.542 1.00 48.93  ? 643  VAL A CB  1 
ATOM   2633 C  CG1 . VAL A 1 380 ? -1.427  -19.521 -38.657 1.00 48.61  ? 643  VAL A CG1 1 
ATOM   2634 C  CG2 . VAL A 1 380 ? 1.027   -19.088 -38.875 1.00 48.39  ? 643  VAL A CG2 1 
ATOM   2635 N  N   . LYS A 1 381 ? -2.200  -18.484 -42.091 1.00 54.39  ? 644  LYS A N   1 
ATOM   2636 C  CA  . LYS A 1 381 ? -3.551  -18.406 -42.689 1.00 52.46  ? 644  LYS A CA  1 
ATOM   2637 C  C   . LYS A 1 381 ? -3.618  -19.318 -43.917 1.00 55.39  ? 644  LYS A C   1 
ATOM   2638 O  O   . LYS A 1 381 ? -4.604  -20.057 -44.032 1.00 51.42  ? 644  LYS A O   1 
ATOM   2639 C  CB  . LYS A 1 381 ? -3.884  -16.950 -43.022 1.00 61.87  ? 644  LYS A CB  1 
ATOM   2640 C  CG  . LYS A 1 381 ? -3.863  -15.980 -41.847 1.00 70.07  ? 644  LYS A CG  1 
ATOM   2641 C  CD  . LYS A 1 381 ? -4.080  -14.541 -42.268 1.00 69.77  ? 644  LYS A CD  1 
ATOM   2642 C  CE  . LYS A 1 381 ? -4.466  -13.622 -41.128 1.00 72.94  ? 644  LYS A CE  1 
ATOM   2643 N  NZ  . LYS A 1 381 ? -3.346  -13.396 -40.186 1.00 75.70  ? 644  LYS A NZ  1 
ATOM   2644 N  N   . ASN A 1 382 ? -2.607  -19.272 -44.783 0.50 50.46  ? 645  ASN A N   1 
ATOM   2645 C  CA  . ASN A 1 382 ? -2.645  -20.079 -46.030 0.50 52.16  ? 645  ASN A CA  1 
ATOM   2646 C  C   . ASN A 1 382 ? -2.558  -21.559 -45.655 0.50 51.72  ? 645  ASN A C   1 
ATOM   2647 O  O   . ASN A 1 382 ? -3.182  -22.378 -46.344 0.50 52.08  ? 645  ASN A O   1 
ATOM   2648 C  CB  . ASN A 1 382 ? -1.555  -19.650 -47.012 0.50 54.39  ? 645  ASN A CB  1 
ATOM   2649 C  CG  . ASN A 1 382 ? -1.766  -18.249 -47.543 0.50 57.31  ? 645  ASN A CG  1 
ATOM   2650 O  OD1 . ASN A 1 382 ? -2.892  -17.760 -47.587 0.50 58.06  ? 645  ASN A OD1 1 
ATOM   2651 N  ND2 . ASN A 1 382 ? -0.690  -17.597 -47.953 0.50 57.64  ? 645  ASN A ND2 1 
ATOM   2652 N  N   . TRP A 1 383 ? -1.810  -21.875 -44.600 1.00 52.75  ? 646  TRP A N   1 
ATOM   2653 C  CA  . TRP A 1 383 ? -1.695  -23.275 -44.118 1.00 48.30  ? 646  TRP A CA  1 
ATOM   2654 C  C   . TRP A 1 383 ? -3.085  -23.770 -43.717 1.00 37.46  ? 646  TRP A C   1 
ATOM   2655 O  O   . TRP A 1 383 ? -3.508  -24.808 -44.219 1.00 36.16  ? 646  TRP A O   1 
ATOM   2656 C  CB  . TRP A 1 383 ? -0.713  -23.311 -42.943 1.00 44.05  ? 646  TRP A CB  1 
ATOM   2657 C  CG  . TRP A 1 383 ? -0.340  -24.672 -42.444 1.00 50.57  ? 646  TRP A CG  1 
ATOM   2658 C  CD1 . TRP A 1 383 ? 0.637   -25.489 -42.933 1.00 47.44  ? 646  TRP A CD1 1 
ATOM   2659 C  CD2 . TRP A 1 383 ? -0.907  -25.360 -41.317 1.00 46.19  ? 646  TRP A CD2 1 
ATOM   2660 N  NE1 . TRP A 1 383 ? 0.703   -26.642 -42.201 1.00 43.54  ? 646  TRP A NE1 1 
ATOM   2661 C  CE2 . TRP A 1 383 ? -0.231  -26.592 -41.203 1.00 48.06  ? 646  TRP A CE2 1 
ATOM   2662 C  CE3 . TRP A 1 383 ? -1.923  -25.062 -40.404 1.00 40.86  ? 646  TRP A CE3 1 
ATOM   2663 C  CZ2 . TRP A 1 383 ? -0.541  -27.521 -40.213 1.00 42.90  ? 646  TRP A CZ2 1 
ATOM   2664 C  CZ3 . TRP A 1 383 ? -2.227  -25.980 -39.426 1.00 40.58  ? 646  TRP A CZ3 1 
ATOM   2665 C  CH2 . TRP A 1 383 ? -1.544  -27.191 -39.333 1.00 40.68  ? 646  TRP A CH2 1 
ATOM   2666 N  N   . LEU A 1 384 ? -3.778  -22.997 -42.894 1.00 38.20  ? 647  LEU A N   1 
ATOM   2667 C  CA  . LEU A 1 384 ? -5.123  -23.383 -42.407 1.00 42.01  ? 647  LEU A CA  1 
ATOM   2668 C  C   . LEU A 1 384 ? -6.080  -23.553 -43.588 1.00 45.15  ? 647  LEU A C   1 
ATOM   2669 O  O   . LEU A 1 384 ? -6.830  -24.526 -43.599 1.00 40.53  ? 647  LEU A O   1 
ATOM   2670 C  CB  . LEU A 1 384 ? -5.585  -22.287 -41.449 1.00 43.12  ? 647  LEU A CB  1 
ATOM   2671 C  CG  . LEU A 1 384 ? -4.874  -22.260 -40.097 1.00 47.67  ? 647  LEU A CG  1 
ATOM   2672 C  CD1 . LEU A 1 384 ? -5.273  -21.033 -39.294 1.00 48.29  ? 647  LEU A CD1 1 
ATOM   2673 C  CD2 . LEU A 1 384 ? -5.159  -23.526 -39.308 1.00 44.31  ? 647  LEU A CD2 1 
ATOM   2674 N  N   . VAL A 1 385 ? -6.018  -22.640 -44.553 1.00 51.19  ? 648  VAL A N   1 
ATOM   2675 C  CA  . VAL A 1 385 ? -6.922  -22.690 -45.734 1.00 53.74  ? 648  VAL A CA  1 
ATOM   2676 C  C   . VAL A 1 385 ? -6.523  -23.857 -46.633 1.00 52.15  ? 648  VAL A C   1 
ATOM   2677 O  O   . VAL A 1 385 ? -7.421  -24.496 -47.192 1.00 55.98  ? 648  VAL A O   1 
ATOM   2678 C  CB  . VAL A 1 385 ? -6.877  -21.353 -46.496 1.00 56.82  ? 648  VAL A CB  1 
ATOM   2679 C  CG1 . VAL A 1 385 ? -7.661  -21.413 -47.796 1.00 56.22  ? 648  VAL A CG1 1 
ATOM   2680 C  CG2 . VAL A 1 385 ? -7.352  -20.197 -45.633 1.00 55.55  ? 648  VAL A CG2 1 
ATOM   2681 N  N   . ARG A 1 386 ? -5.231  -24.135 -46.750 0.50 52.15  ? 649  ARG A N   1 
ATOM   2682 C  CA  . ARG A 1 386 ? -4.776  -25.171 -47.710 0.50 53.27  ? 649  ARG A CA  1 
ATOM   2683 C  C   . ARG A 1 386 ? -4.848  -26.577 -47.107 0.50 51.57  ? 649  ARG A C   1 
ATOM   2684 O  O   . ARG A 1 386 ? -5.247  -27.496 -47.839 0.50 49.58  ? 649  ARG A O   1 
ATOM   2685 C  CB  . ARG A 1 386 ? -3.352  -24.832 -48.161 0.50 57.97  ? 649  ARG A CB  1 
ATOM   2686 C  CG  . ARG A 1 386 ? -2.781  -25.766 -49.217 0.50 61.87  ? 649  ARG A CG  1 
ATOM   2687 C  CD  . ARG A 1 386 ? -1.363  -25.392 -49.608 0.50 63.89  ? 649  ARG A CD  1 
ATOM   2688 N  NE  . ARG A 1 386 ? -0.380  -25.644 -48.562 0.50 63.27  ? 649  ARG A NE  1 
ATOM   2689 C  CZ  . ARG A 1 386 ? 0.069   -24.734 -47.705 0.50 62.64  ? 649  ARG A CZ  1 
ATOM   2690 N  NH1 . ARG A 1 386 ? -0.373  -23.490 -47.763 0.50 61.77  ? 649  ARG A NH1 1 
ATOM   2691 N  NH2 . ARG A 1 386 ? 0.964   -25.071 -46.795 0.50 62.04  ? 649  ARG A NH2 1 
ATOM   2692 N  N   . VAL A 1 387 ? -4.486  -26.751 -45.833 1.00 48.41  ? 650  VAL A N   1 
ATOM   2693 C  CA  . VAL A 1 387 ? -4.421  -28.149 -45.307 1.00 48.43  ? 650  VAL A CA  1 
ATOM   2694 C  C   . VAL A 1 387 ? -5.022  -28.305 -43.904 1.00 44.13  ? 650  VAL A C   1 
ATOM   2695 O  O   . VAL A 1 387 ? -4.923  -29.416 -43.371 1.00 44.12  ? 650  VAL A O   1 
ATOM   2696 C  CB  . VAL A 1 387 ? -2.952  -28.607 -45.307 1.00 43.74  ? 650  VAL A CB  1 
ATOM   2697 C  CG1 . VAL A 1 387 ? -2.367  -28.654 -46.708 1.00 45.16  ? 650  VAL A CG1 1 
ATOM   2698 C  CG2 . VAL A 1 387 ? -2.100  -27.737 -44.395 1.00 41.96  ? 650  VAL A CG2 1 
ATOM   2699 N  N   . GLY A 1 388 ? -5.637  -27.262 -43.346 1.00 42.00  ? 651  GLY A N   1 
ATOM   2700 C  CA  . GLY A 1 388 ? -6.160  -27.312 -41.967 1.00 40.80  ? 651  GLY A CA  1 
ATOM   2701 C  C   . GLY A 1 388 ? -7.121  -28.460 -41.734 1.00 41.55  ? 651  GLY A C   1 
ATOM   2702 O  O   . GLY A 1 388 ? -7.041  -29.084 -40.676 1.00 41.33  ? 651  GLY A O   1 
ATOM   2703 N  N   . ARG A 1 389 ? -7.994  -28.725 -42.696 1.00 39.45  ? 652  ARG A N   1 
ATOM   2704 C  CA  . ARG A 1 389 ? -9.006  -29.794 -42.537 1.00 43.68  ? 652  ARG A CA  1 
ATOM   2705 C  C   . ARG A 1 389 ? -8.296  -31.149 -42.572 1.00 39.69  ? 652  ARG A C   1 
ATOM   2706 O  O   . ARG A 1 389 ? -8.663  -32.019 -41.780 1.00 41.46  ? 652  ARG A O   1 
ATOM   2707 C  CB  . ARG A 1 389 ? -10.107 -29.655 -43.595 1.00 37.20  ? 652  ARG A CB  1 
ATOM   2708 C  CG  . ARG A 1 389 ? -11.002 -28.439 -43.408 1.00 41.69  ? 652  ARG A CG  1 
ATOM   2709 C  CD  . ARG A 1 389 ? -12.098 -28.343 -44.451 1.00 44.61  ? 652  ARG A CD  1 
ATOM   2710 N  NE  . ARG A 1 389 ? -12.997 -29.486 -44.436 1.00 47.39  ? 652  ARG A NE  1 
ATOM   2711 C  CZ  . ARG A 1 389 ? -14.076 -29.585 -43.670 1.00 44.99  ? 652  ARG A CZ  1 
ATOM   2712 N  NH1 . ARG A 1 389 ? -14.396 -28.604 -42.845 1.00 46.67  ? 652  ARG A NH1 1 
ATOM   2713 N  NH2 . ARG A 1 389 ? -14.827 -30.667 -43.728 1.00 49.29  ? 652  ARG A NH2 1 
ATOM   2714 N  N   . GLU A 1 390 ? -7.301  -31.299 -43.440 1.00 38.47  ? 653  GLU A N   1 
ATOM   2715 C  CA  . GLU A 1 390 ? -6.522  -32.564 -43.453 1.00 41.85  ? 653  GLU A CA  1 
ATOM   2716 C  C   . GLU A 1 390 ? -5.837  -32.739 -42.095 1.00 33.56  ? 653  GLU A C   1 
ATOM   2717 O  O   . GLU A 1 390 ? -5.833  -33.854 -41.584 1.00 38.61  ? 653  GLU A O   1 
ATOM   2718 C  CB  . GLU A 1 390 ? -5.524  -32.590 -44.611 1.00 40.31  ? 653  GLU A CB  1 
ATOM   2719 C  CG  . GLU A 1 390 ? -5.003  -33.976 -44.935 1.00 38.92  ? 653  GLU A CG  1 
ATOM   2720 C  CD  . GLU A 1 390 ? -3.865  -34.469 -44.059 1.00 41.39  ? 653  GLU A CD  1 
ATOM   2721 O  OE1 . GLU A 1 390 ? -3.324  -33.667 -43.284 1.00 37.51  ? 653  GLU A OE1 1 
ATOM   2722 O  OE2 . GLU A 1 390 ? -3.523  -35.657 -44.161 1.00 46.22  ? 653  GLU A OE2 1 
ATOM   2723 N  N   . ARG A 1 391 ? -5.325  -31.657 -41.525 1.00 32.85  ? 654  ARG A N   1 
ATOM   2724 C  CA  . ARG A 1 391 ? -4.565  -31.753 -40.256 1.00 33.21  ? 654  ARG A CA  1 
ATOM   2725 C  C   . ARG A 1 391 ? -5.504  -32.112 -39.102 1.00 32.93  ? 654  ARG A C   1 
ATOM   2726 O  O   . ARG A 1 391 ? -5.068  -32.841 -38.209 1.00 33.79  ? 654  ARG A O   1 
ATOM   2727 C  CB  . ARG A 1 391 ? -3.784  -30.457 -40.030 1.00 37.23  ? 654  ARG A CB  1 
ATOM   2728 C  CG  . ARG A 1 391 ? -2.767  -30.151 -41.120 1.00 38.96  ? 654  ARG A CG  1 
ATOM   2729 C  CD  . ARG A 1 391 ? -1.720  -31.237 -41.270 1.00 40.96  ? 654  ARG A CD  1 
ATOM   2730 N  NE  . ARG A 1 391 ? -0.616  -30.812 -42.115 1.00 44.81  ? 654  ARG A NE  1 
ATOM   2731 C  CZ  . ARG A 1 391 ? -0.501  -31.087 -43.407 1.00 48.12  ? 654  ARG A CZ  1 
ATOM   2732 N  NH1 . ARG A 1 391 ? -1.423  -31.807 -44.020 1.00 48.20  ? 654  ARG A NH1 1 
ATOM   2733 N  NH2 . ARG A 1 391 ? 0.542   -30.646 -44.084 1.00 53.59  ? 654  ARG A NH2 1 
ATOM   2734 N  N   . LEU A 1 392 ? -6.738  -31.620 -39.139 1.00 35.69  ? 655  LEU A N   1 
ATOM   2735 C  CA  . LEU A 1 392 ? -7.744  -31.959 -38.099 1.00 34.75  ? 655  LEU A CA  1 
ATOM   2736 C  C   . LEU A 1 392 ? -8.107  -33.444 -38.205 1.00 30.07  ? 655  LEU A C   1 
ATOM   2737 O  O   . LEU A 1 392 ? -8.318  -34.067 -37.170 1.00 31.60  ? 655  LEU A O   1 
ATOM   2738 C  CB  . LEU A 1 392 ? -8.972  -31.066 -38.289 1.00 38.14  ? 655  LEU A CB  1 
ATOM   2739 C  CG  . LEU A 1 392 ? -8.821  -29.597 -37.903 1.00 35.92  ? 655  LEU A CG  1 
ATOM   2740 C  CD1 . LEU A 1 392 ? -10.059 -28.818 -38.313 1.00 37.56  ? 655  LEU A CD1 1 
ATOM   2741 C  CD2 . LEU A 1 392 ? -8.574  -29.447 -36.413 1.00 30.19  ? 655  LEU A CD2 1 
ATOM   2742 N  N   . SER A 1 393 ? -8.142  -33.977 -39.421 1.00 32.57  ? 656  SER A N   1 
ATOM   2743 C  CA  . SER A 1 393 ? -8.491  -35.400 -39.653 1.00 33.85  ? 656  SER A CA  1 
ATOM   2744 C  C   . SER A 1 393 ? -7.396  -36.330 -39.124 1.00 37.34  ? 656  SER A C   1 
ATOM   2745 O  O   . SER A 1 393 ? -7.662  -37.528 -39.022 1.00 31.91  ? 656  SER A O   1 
ATOM   2746 C  CB  . SER A 1 393 ? -8.739  -35.632 -41.113 1.00 39.32  ? 656  SER A CB  1 
ATOM   2747 O  OG  . SER A 1 393 ? -7.553  -35.486 -41.869 1.00 44.71  ? 656  SER A OG  1 
ATOM   2748 N  N   . ARG A 1 394 ? -6.212  -35.785 -38.830 1.00 33.62  ? 657  ARG A N   1 
ATOM   2749 C  CA  . ARG A 1 394 ? -5.074  -36.583 -38.310 1.00 34.83  ? 657  ARG A CA  1 
ATOM   2750 C  C   . ARG A 1 394 ? -5.171  -36.665 -36.784 1.00 31.98  ? 657  ARG A C   1 
ATOM   2751 O  O   . ARG A 1 394 ? -4.246  -37.190 -36.164 1.00 30.71  ? 657  ARG A O   1 
ATOM   2752 C  CB  . ARG A 1 394 ? -3.758  -35.907 -38.699 1.00 36.32  ? 657  ARG A CB  1 
ATOM   2753 C  CG  . ARG A 1 394 ? -3.533  -35.774 -40.194 1.00 40.99  ? 657  ARG A CG  1 
ATOM   2754 C  CD  . ARG A 1 394 ? -2.196  -35.138 -40.515 1.00 37.91  ? 657  ARG A CD  1 
ATOM   2755 N  NE  . ARG A 1 394 ? -1.825  -35.566 -41.849 1.00 38.27  ? 657  ARG A NE  1 
ATOM   2756 C  CZ  . ARG A 1 394 ? -1.075  -36.625 -42.108 1.00 43.60  ? 657  ARG A CZ  1 
ATOM   2757 N  NH1 . ARG A 1 394 ? -0.587  -37.348 -41.117 1.00 44.22  ? 657  ARG A NH1 1 
ATOM   2758 N  NH2 . ARG A 1 394 ? -0.805  -36.950 -43.357 1.00 46.78  ? 657  ARG A NH2 1 
ATOM   2759 N  N   . MET A 1 395 ? -6.255  -36.141 -36.222 1.00 29.40  ? 658  MET A N   1 
ATOM   2760 C  CA  . MET A 1 395 ? -6.402  -36.104 -34.747 1.00 30.09  ? 658  MET A CA  1 
ATOM   2761 C  C   . MET A 1 395 ? -7.719  -36.728 -34.262 1.00 30.80  ? 658  MET A C   1 
ATOM   2762 O  O   . MET A 1 395 ? -8.716  -36.685 -34.964 1.00 27.18  ? 658  MET A O   1 
ATOM   2763 C  CB  . MET A 1 395 ? -6.247  -34.677 -34.238 1.00 28.72  ? 658  MET A CB  1 
ATOM   2764 C  CG  . MET A 1 395 ? -5.005  -33.920 -34.796 1.00 29.27  ? 658  MET A CG  1 
ATOM   2765 S  SD  . MET A 1 395 ? -4.705  -32.390 -33.868 1.00 31.97  ? 658  MET A SD  1 
ATOM   2766 C  CE  . MET A 1 395 ? -5.916  -31.271 -34.566 1.00 33.62  ? 658  MET A CE  1 
ATOM   2767 N  N   . ALA A 1 396 ? -7.668  -37.322 -33.066 1.00 29.46  ? 659  ALA A N   1 
ATOM   2768 C  CA  . ALA A 1 396 ? -8.846  -37.716 -32.286 1.00 29.76  ? 659  ALA A CA  1 
ATOM   2769 C  C   . ALA A 1 396 ? -8.763  -36.972 -30.955 1.00 30.16  ? 659  ALA A C   1 
ATOM   2770 O  O   . ALA A 1 396 ? -7.826  -37.209 -30.251 1.00 28.59  ? 659  ALA A O   1 
ATOM   2771 C  CB  . ALA A 1 396 ? -8.910  -39.207 -32.122 1.00 29.42  ? 659  ALA A CB  1 
ATOM   2772 N  N   . ILE A 1 397 ? -9.726  -36.088 -30.669 1.00 28.79  ? 660  ILE A N   1 
ATOM   2773 C  CA  . ILE A 1 397 ? -9.675  -35.155 -29.530 1.00 28.33  ? 660  ILE A CA  1 
ATOM   2774 C  C   . ILE A 1 397 ? -11.000 -35.264 -28.768 1.00 32.58  ? 660  ILE A C   1 
ATOM   2775 O  O   . ILE A 1 397 ? -12.070 -34.978 -29.321 1.00 28.70  ? 660  ILE A O   1 
ATOM   2776 C  CB  . ILE A 1 397 ? -9.348  -33.734 -30.021 1.00 28.17  ? 660  ILE A CB  1 
ATOM   2777 C  CG1 . ILE A 1 397 ? -7.971  -33.710 -30.702 1.00 33.55  ? 660  ILE A CG1 1 
ATOM   2778 C  CG2 . ILE A 1 397 ? -9.452  -32.788 -28.846 1.00 32.49  ? 660  ILE A CG2 1 
ATOM   2779 C  CD1 . ILE A 1 397 ? -7.408  -32.390 -31.114 1.00 29.58  ? 660  ILE A CD1 1 
ATOM   2780 N  N   . SER A 1 398 ? -10.900 -35.678 -27.517 1.00 32.69  ? 661  SER A N   1 
ATOM   2781 C  CA  . SER A 1 398 ? -12.003 -35.761 -26.557 1.00 35.80  ? 661  SER A CA  1 
ATOM   2782 C  C   . SER A 1 398 ? -11.675 -34.851 -25.376 1.00 32.85  ? 661  SER A C   1 
ATOM   2783 O  O   . SER A 1 398 ? -10.971 -35.287 -24.497 1.00 35.70  ? 661  SER A O   1 
ATOM   2784 C  CB  . SER A 1 398 ? -12.253 -37.188 -26.146 1.00 34.67  ? 661  SER A CB  1 
ATOM   2785 O  OG  . SER A 1 398 ? -13.544 -37.306 -25.581 1.00 34.28  ? 661  SER A OG  1 
ATOM   2786 N  N   . GLY A 1 399 ? -12.220 -33.635 -25.354 1.00 30.89  ? 662  GLY A N   1 
ATOM   2787 C  CA  . GLY A 1 399 ? -11.908 -32.669 -24.285 1.00 31.50  ? 662  GLY A CA  1 
ATOM   2788 C  C   . GLY A 1 399 ? -10.404 -32.476 -24.142 1.00 31.07  ? 662  GLY A C   1 
ATOM   2789 O  O   . GLY A 1 399 ? -9.739  -32.151 -25.147 1.00 31.25  ? 662  GLY A O   1 
ATOM   2790 N  N   . ASP A 1 400 ? -9.848  -32.701 -22.960 1.00 29.62  ? 663  ASP A N   1 
ATOM   2791 C  CA  . ASP A 1 400 ? -8.394  -32.503 -22.745 1.00 34.58  ? 663  ASP A CA  1 
ATOM   2792 C  C   . ASP A 1 400 ? -7.593  -33.705 -23.255 1.00 33.43  ? 663  ASP A C   1 
ATOM   2793 O  O   . ASP A 1 400 ? -6.371  -33.661 -23.145 1.00 30.87  ? 663  ASP A O   1 
ATOM   2794 C  CB  . ASP A 1 400 ? -8.080  -32.237 -21.278 1.00 38.00  ? 663  ASP A CB  1 
ATOM   2795 C  CG  . ASP A 1 400 ? -8.391  -33.413 -20.383 1.00 41.71  ? 663  ASP A CG  1 
ATOM   2796 O  OD1 . ASP A 1 400 ? -9.108  -34.323 -20.830 1.00 43.79  ? 663  ASP A OD1 1 
ATOM   2797 O  OD2 . ASP A 1 400 ? -7.857  -33.430 -19.281 1.00 49.00  ? 663  ASP A OD2 1 
ATOM   2798 N  N   . ASP A 1 401 ? -8.241  -34.725 -23.789 1.00 29.42  ? 664  ASP A N   1 
ATOM   2799 C  CA  . ASP A 1 401 ? -7.555  -35.966 -24.202 1.00 30.61  ? 664  ASP A CA  1 
ATOM   2800 C  C   . ASP A 1 401 ? -7.322  -35.928 -25.704 1.00 29.91  ? 664  ASP A C   1 
ATOM   2801 O  O   . ASP A 1 401 ? -8.239  -35.548 -26.414 1.00 32.79  ? 664  ASP A O   1 
ATOM   2802 C  CB  . ASP A 1 401 ? -8.319  -37.228 -23.793 1.00 32.82  ? 664  ASP A CB  1 
ATOM   2803 C  CG  . ASP A 1 401 ? -7.372  -38.403 -23.703 1.00 33.25  ? 664  ASP A CG  1 
ATOM   2804 O  OD1 . ASP A 1 401 ? -6.198  -38.132 -23.773 1.00 34.95  ? 664  ASP A OD1 1 
ATOM   2805 O  OD2 . ASP A 1 401 ? -7.806  -39.533 -23.677 1.00 33.69  ? 664  ASP A OD2 1 
ATOM   2806 N  N   . CYS A 1 402 ? -6.135  -36.302 -26.174 1.00 28.19  ? 665  CYS A N   1 
ATOM   2807 C  CA  . CYS A 1 402 ? -5.847  -36.294 -27.631 1.00 28.85  ? 665  CYS A CA  1 
ATOM   2808 C  C   . CYS A 1 402 ? -4.896  -37.408 -28.097 1.00 31.12  ? 665  CYS A C   1 
ATOM   2809 O  O   . CYS A 1 402 ? -4.047  -37.892 -27.324 1.00 31.59  ? 665  CYS A O   1 
ATOM   2810 C  CB  . CYS A 1 402 ? -5.274  -34.957 -28.071 1.00 35.26  ? 665  CYS A CB  1 
ATOM   2811 S  SG  . CYS A 1 402 ? -3.585  -34.626 -27.481 1.00 35.84  ? 665  CYS A SG  1 
ATOM   2812 N  N   . VAL A 1 403 ? -5.035  -37.729 -29.388 1.00 31.40  ? 666  VAL A N   1 
ATOM   2813 C  CA  . VAL A 1 403 ? -4.133  -38.586 -30.202 1.00 30.26  ? 666  VAL A CA  1 
ATOM   2814 C  C   . VAL A 1 403 ? -3.908  -37.800 -31.508 1.00 33.88  ? 666  VAL A C   1 
ATOM   2815 O  O   . VAL A 1 403 ? -4.902  -37.305 -32.087 1.00 33.60  ? 666  VAL A O   1 
ATOM   2816 C  CB  . VAL A 1 403 ? -4.774  -39.961 -30.444 1.00 29.25  ? 666  VAL A CB  1 
ATOM   2817 C  CG1 . VAL A 1 403 ? -3.908  -40.847 -31.327 1.00 32.02  ? 666  VAL A CG1 1 
ATOM   2818 C  CG2 . VAL A 1 403 ? -5.117  -40.665 -29.141 1.00 26.49  ? 666  VAL A CG2 1 
ATOM   2819 N  N   . VAL A 1 404 ? -2.653  -37.563 -31.883 1.00 31.50  ? 667  VAL A N   1 
ATOM   2820 C  CA  . VAL A 1 404 ? -2.239  -36.839 -33.125 1.00 28.40  ? 667  VAL A CA  1 
ATOM   2821 C  C   . VAL A 1 404 ? -1.302  -37.744 -33.909 1.00 28.94  ? 667  VAL A C   1 
ATOM   2822 O  O   . VAL A 1 404 ? -0.297  -38.245 -33.318 1.00 29.28  ? 667  VAL A O   1 
ATOM   2823 C  CB  . VAL A 1 404 ? -1.565  -35.492 -32.821 1.00 30.64  ? 667  VAL A CB  1 
ATOM   2824 C  CG1 . VAL A 1 404 ? -1.300  -34.682 -34.077 1.00 28.95  ? 667  VAL A CG1 1 
ATOM   2825 C  CG2 . VAL A 1 404 ? -2.317  -34.649 -31.811 1.00 32.70  ? 667  VAL A CG2 1 
ATOM   2826 N  N   . LYS A 1 405 ? -1.616  -37.967 -35.178 1.00 30.49  ? 668  LYS A N   1 
ATOM   2827 C  CA  . LYS A 1 405 ? -0.673  -38.542 -36.157 1.00 31.00  ? 668  LYS A CA  1 
ATOM   2828 C  C   . LYS A 1 405 ? -0.173  -37.428 -37.086 1.00 35.17  ? 668  LYS A C   1 
ATOM   2829 O  O   . LYS A 1 405 ? -0.744  -37.147 -38.151 1.00 33.48  ? 668  LYS A O   1 
ATOM   2830 C  CB  . LYS A 1 405 ? -1.294  -39.653 -36.987 1.00 33.19  ? 668  LYS A CB  1 
ATOM   2831 C  CG  . LYS A 1 405 ? -0.243  -40.269 -37.879 1.00 34.33  ? 668  LYS A CG  1 
ATOM   2832 C  CD  . LYS A 1 405 ? -0.469  -41.672 -38.286 1.00 37.17  ? 668  LYS A CD  1 
ATOM   2833 C  CE  . LYS A 1 405 ? 0.795   -42.233 -38.903 1.00 36.70  ? 668  LYS A CE  1 
ATOM   2834 N  NZ  . LYS A 1 405 ? 0.472   -43.391 -39.751 1.00 44.31  ? 668  LYS A NZ  1 
ATOM   2835 N  N   . PRO A 1 406 ? 0.922   -36.734 -36.710 1.00 35.23  ? 669  PRO A N   1 
ATOM   2836 C  CA  . PRO A 1 406 ? 1.437   -35.630 -37.514 1.00 33.76  ? 669  PRO A CA  1 
ATOM   2837 C  C   . PRO A 1 406 ? 2.049   -36.091 -38.840 1.00 33.29  ? 669  PRO A C   1 
ATOM   2838 O  O   . PRO A 1 406 ? 2.244   -37.273 -39.109 1.00 35.04  ? 669  PRO A O   1 
ATOM   2839 C  CB  . PRO A 1 406 ? 2.510   -35.040 -36.611 1.00 33.17  ? 669  PRO A CB  1 
ATOM   2840 C  CG  . PRO A 1 406 ? 3.001   -36.261 -35.871 1.00 34.10  ? 669  PRO A CG  1 
ATOM   2841 C  CD  . PRO A 1 406 ? 1.697   -36.927 -35.485 1.00 33.04  ? 669  PRO A CD  1 
ATOM   2842 N  N   . LEU A 1 407 ? 2.394   -35.111 -39.651 1.00 37.12  ? 670  LEU A N   1 
ATOM   2843 C  CA  . LEU A 1 407 ? 2.997   -35.339 -40.989 1.00 40.55  ? 670  LEU A CA  1 
ATOM   2844 C  C   . LEU A 1 407 ? 4.308   -36.142 -40.840 1.00 37.87  ? 670  LEU A C   1 
ATOM   2845 O  O   . LEU A 1 407 ? 4.556   -37.038 -41.685 1.00 36.02  ? 670  LEU A O   1 
ATOM   2846 C  CB  . LEU A 1 407 ? 3.197   -33.961 -41.636 1.00 43.09  ? 670  LEU A CB  1 
ATOM   2847 C  CG  . LEU A 1 407 ? 3.175   -33.958 -43.156 1.00 51.83  ? 670  LEU A CG  1 
ATOM   2848 C  CD1 . LEU A 1 407 ? 1.781   -34.246 -43.659 1.00 56.26  ? 670  LEU A CD1 1 
ATOM   2849 C  CD2 . LEU A 1 407 ? 3.662   -32.627 -43.704 1.00 61.52  ? 670  LEU A CD2 1 
ATOM   2850 N  N   . ASP A 1 408 ? 5.088   -35.884 -39.784 1.00 34.40  ? 671  ASP A N   1 
ATOM   2851 C  CA  . ASP A 1 408 ? 6.338   -36.646 -39.476 1.00 38.33  ? 671  ASP A CA  1 
ATOM   2852 C  C   . ASP A 1 408 ? 6.716   -36.447 -38.013 1.00 35.87  ? 671  ASP A C   1 
ATOM   2853 O  O   . ASP A 1 408 ? 5.947   -35.799 -37.319 1.00 37.71  ? 671  ASP A O   1 
ATOM   2854 C  CB  . ASP A 1 408 ? 7.460   -36.196 -40.420 1.00 38.47  ? 671  ASP A CB  1 
ATOM   2855 C  CG  . ASP A 1 408 ? 7.518   -34.698 -40.482 1.00 35.28  ? 671  ASP A CG  1 
ATOM   2856 O  OD1 . ASP A 1 408 ? 7.806   -34.105 -39.424 1.00 38.15  ? 671  ASP A OD1 1 
ATOM   2857 O  OD2 . ASP A 1 408 ? 7.156   -34.139 -41.538 1.00 43.61  ? 671  ASP A OD2 1 
ATOM   2858 N  N   . ASP A 1 409 ? 7.906   -36.879 -37.592 1.00 34.83  ? 672  ASP A N   1 
ATOM   2859 C  CA  . ASP A 1 409 ? 8.273   -36.906 -36.154 1.00 34.25  ? 672  ASP A CA  1 
ATOM   2860 C  C   . ASP A 1 409 ? 8.946   -35.608 -35.685 1.00 31.01  ? 672  ASP A C   1 
ATOM   2861 O  O   . ASP A 1 409 ? 9.238   -35.511 -34.477 1.00 35.53  ? 672  ASP A O   1 
ATOM   2862 C  CB  . ASP A 1 409 ? 9.020   -38.198 -35.841 1.00 38.04  ? 672  ASP A CB  1 
ATOM   2863 C  CG  . ASP A 1 409 ? 8.114   -39.406 -35.956 1.00 43.49  ? 672  ASP A CG  1 
ATOM   2864 O  OD1 . ASP A 1 409 ? 7.010   -39.391 -35.325 1.00 40.42  ? 672  ASP A OD1 1 
ATOM   2865 O  OD2 . ASP A 1 409 ? 8.484   -40.327 -36.694 1.00 48.01  ? 672  ASP A OD2 1 
ATOM   2866 N  N   . ARG A 1 410 ? 9.046   -34.570 -36.507 1.00 33.81  ? 673  ARG A N   1 
ATOM   2867 C  CA  . ARG A 1 410 ? 9.473   -33.238 -35.984 1.00 34.85  ? 673  ARG A CA  1 
ATOM   2868 C  C   . ARG A 1 410 ? 8.542   -32.741 -34.877 1.00 35.27  ? 673  ARG A C   1 
ATOM   2869 O  O   . ARG A 1 410 ? 8.991   -31.958 -34.007 1.00 36.42  ? 673  ARG A O   1 
ATOM   2870 C  CB  . ARG A 1 410 ? 9.466   -32.210 -37.107 1.00 40.42  ? 673  ARG A CB  1 
ATOM   2871 C  CG  . ARG A 1 410 ? 10.531  -32.459 -38.167 1.00 43.89  ? 673  ARG A CG  1 
ATOM   2872 C  CD  . ARG A 1 410 ? 10.380  -31.401 -39.230 1.00 41.29  ? 673  ARG A CD  1 
ATOM   2873 N  NE  . ARG A 1 410 ? 9.247   -31.711 -40.089 1.00 42.31  ? 673  ARG A NE  1 
ATOM   2874 C  CZ  . ARG A 1 410 ? 8.731   -30.914 -41.016 1.00 47.02  ? 673  ARG A CZ  1 
ATOM   2875 N  NH1 . ARG A 1 410 ? 9.235   -29.702 -41.209 1.00 44.25  ? 673  ARG A NH1 1 
ATOM   2876 N  NH2 . ARG A 1 410 ? 7.706   -31.338 -41.749 1.00 46.14  ? 673  ARG A NH2 1 
ATOM   2877 N  N   . PHE A 1 411 ? 7.262   -33.143 -34.927 1.00 35.73  ? 674  PHE A N   1 
ATOM   2878 C  CA  . PHE A 1 411 ? 6.206   -32.833 -33.926 1.00 29.75  ? 674  PHE A CA  1 
ATOM   2879 C  C   . PHE A 1 411 ? 6.695   -33.173 -32.513 1.00 28.26  ? 674  PHE A C   1 
ATOM   2880 O  O   . PHE A 1 411 ? 6.409   -32.377 -31.581 1.00 30.59  ? 674  PHE A O   1 
ATOM   2881 C  CB  . PHE A 1 411 ? 4.942   -33.630 -34.309 1.00 37.59  ? 674  PHE A CB  1 
ATOM   2882 C  CG  . PHE A 1 411 ? 3.770   -33.481 -33.387 1.00 33.45  ? 674  PHE A CG  1 
ATOM   2883 C  CD1 . PHE A 1 411 ? 3.701   -34.213 -32.217 1.00 33.93  ? 674  PHE A CD1 1 
ATOM   2884 C  CD2 . PHE A 1 411 ? 2.709   -32.634 -33.714 1.00 34.57  ? 674  PHE A CD2 1 
ATOM   2885 C  CE1 . PHE A 1 411 ? 2.590   -34.081 -31.376 1.00 35.42  ? 674  PHE A CE1 1 
ATOM   2886 C  CE2 . PHE A 1 411 ? 1.621   -32.487 -32.863 1.00 34.23  ? 674  PHE A CE2 1 
ATOM   2887 C  CZ  . PHE A 1 411 ? 1.553   -33.215 -31.695 1.00 32.56  ? 674  PHE A CZ  1 
ATOM   2888 N  N   . ALA A 1 412 ? 7.432   -34.285 -32.336 1.00 31.08  ? 675  ALA A N   1 
ATOM   2889 C  CA  . ALA A 1 412 ? 7.891   -34.777 -31.011 1.00 31.96  ? 675  ALA A CA  1 
ATOM   2890 C  C   . ALA A 1 412 ? 8.715   -33.739 -30.245 1.00 33.33  ? 675  ALA A C   1 
ATOM   2891 O  O   . ALA A 1 412 ? 8.602   -33.686 -29.002 1.00 29.31  ? 675  ALA A O   1 
ATOM   2892 C  CB  . ALA A 1 412 ? 8.672   -36.055 -31.170 1.00 33.90  ? 675  ALA A CB  1 
ATOM   2893 N  N   . SER A 1 413 ? 9.499   -32.907 -30.937 1.00 33.33  ? 676  SER A N   1 
ATOM   2894 C  CA  . SER A 1 413 ? 10.312  -31.869 -30.254 1.00 39.55  ? 676  SER A CA  1 
ATOM   2895 C  C   . SER A 1 413 ? 9.778   -30.454 -30.537 1.00 42.17  ? 676  SER A C   1 
ATOM   2896 O  O   . SER A 1 413 ? 10.433  -29.496 -30.121 1.00 42.36  ? 676  SER A O   1 
ATOM   2897 C  CB  . SER A 1 413 ? 11.785  -32.016 -30.607 1.00 39.03  ? 676  SER A CB  1 
ATOM   2898 O  OG  . SER A 1 413 ? 11.941  -32.214 -32.010 1.00 45.13  ? 676  SER A OG  1 
ATOM   2899 N  N   . ALA A 1 414 ? 8.586   -30.301 -31.122 1.00 42.57  ? 677  ALA A N   1 
ATOM   2900 C  CA  . ALA A 1 414 ? 7.957   -28.976 -31.346 1.00 40.79  ? 677  ALA A CA  1 
ATOM   2901 C  C   . ALA A 1 414 ? 7.208   -28.595 -30.072 1.00 41.58  ? 677  ALA A C   1 
ATOM   2902 O  O   . ALA A 1 414 ? 6.014   -28.970 -29.943 1.00 43.55  ? 677  ALA A O   1 
ATOM   2903 C  CB  . ALA A 1 414 ? 7.049   -29.030 -32.543 1.00 41.11  ? 677  ALA A CB  1 
ATOM   2904 N  N   . LEU A 1 415 ? 7.870   -27.925 -29.143 1.00 37.23  ? 678  LEU A N   1 
ATOM   2905 C  CA  . LEU A 1 415 ? 7.351   -27.784 -27.769 1.00 37.47  ? 678  LEU A CA  1 
ATOM   2906 C  C   . LEU A 1 415 ? 7.237   -26.325 -27.349 1.00 37.92  ? 678  LEU A C   1 
ATOM   2907 O  O   . LEU A 1 415 ? 6.699   -26.102 -26.234 1.00 42.78  ? 678  LEU A O   1 
ATOM   2908 C  CB  . LEU A 1 415 ? 8.222   -28.557 -26.776 1.00 36.37  ? 678  LEU A CB  1 
ATOM   2909 C  CG  . LEU A 1 415 ? 8.313   -30.074 -26.981 1.00 39.70  ? 678  LEU A CG  1 
ATOM   2910 C  CD1 . LEU A 1 415 ? 9.460   -30.654 -26.164 1.00 41.14  ? 678  LEU A CD1 1 
ATOM   2911 C  CD2 . LEU A 1 415 ? 7.026   -30.781 -26.584 1.00 42.56  ? 678  LEU A CD2 1 
ATOM   2912 N  N   . THR A 1 416 ? 7.640   -25.355 -28.158 1.00 36.07  ? 679  THR A N   1 
ATOM   2913 C  CA  . THR A 1 416 ? 7.737   -23.960 -27.633 1.00 40.79  ? 679  THR A CA  1 
ATOM   2914 C  C   . THR A 1 416 ? 6.312   -23.411 -27.510 1.00 36.99  ? 679  THR A C   1 
ATOM   2915 O  O   . THR A 1 416 ? 5.941   -22.923 -26.414 1.00 38.34  ? 679  THR A O   1 
ATOM   2916 C  CB  . THR A 1 416 ? 8.678   -23.089 -28.476 1.00 44.48  ? 679  THR A CB  1 
ATOM   2917 O  OG1 . THR A 1 416 ? 8.137   -22.938 -29.780 1.00 43.80  ? 679  THR A OG1 1 
ATOM   2918 C  CG2 . THR A 1 416 ? 10.068  -23.687 -28.632 1.00 49.36  ? 679  THR A CG2 1 
ATOM   2919 N  N   . ALA A 1 417 ? 5.530   -23.499 -28.587 1.00 37.69  ? 680  ALA A N   1 
ATOM   2920 C  CA  . ALA A 1 417 ? 4.130   -23.000 -28.582 1.00 40.93  ? 680  ALA A CA  1 
ATOM   2921 C  C   . ALA A 1 417 ? 3.352   -23.726 -27.477 1.00 44.12  ? 680  ALA A C   1 
ATOM   2922 O  O   . ALA A 1 417 ? 2.662   -23.026 -26.694 1.00 47.39  ? 680  ALA A O   1 
ATOM   2923 C  CB  . ALA A 1 417 ? 3.499   -23.157 -29.938 1.00 42.64  ? 680  ALA A CB  1 
ATOM   2924 N  N   . LEU A 1 418 ? 3.473   -25.064 -27.396 1.00 41.06  ? 681  LEU A N   1 
ATOM   2925 C  CA  . LEU A 1 418 ? 2.685   -25.894 -26.442 1.00 40.02  ? 681  LEU A CA  1 
ATOM   2926 C  C   . LEU A 1 418 ? 2.987   -25.478 -25.007 1.00 39.06  ? 681  LEU A C   1 
ATOM   2927 O  O   . LEU A 1 418 ? 2.021   -25.295 -24.210 1.00 39.29  ? 681  LEU A O   1 
ATOM   2928 C  CB  . LEU A 1 418 ? 3.019   -27.377 -26.651 1.00 43.38  ? 681  LEU A CB  1 
ATOM   2929 C  CG  . LEU A 1 418 ? 2.125   -28.365 -25.897 1.00 42.48  ? 681  LEU A CG  1 
ATOM   2930 C  CD1 . LEU A 1 418 ? 0.736   -28.428 -26.529 1.00 43.14  ? 681  LEU A CD1 1 
ATOM   2931 C  CD2 . LEU A 1 418 ? 2.759   -29.738 -25.885 1.00 42.54  ? 681  LEU A CD2 1 
ATOM   2932 N  N   . ASN A 1 419 ? 4.278   -25.402 -24.647 1.00 41.09  ? 682  ASN A N   1 
ATOM   2933 C  CA  . ASN A 1 419 ? 4.711   -24.968 -23.287 1.00 39.69  ? 682  ASN A CA  1 
ATOM   2934 C  C   . ASN A 1 419 ? 4.267   -23.516 -23.025 1.00 38.95  ? 682  ASN A C   1 
ATOM   2935 O  O   . ASN A 1 419 ? 3.773   -23.250 -21.918 1.00 40.09  ? 682  ASN A O   1 
ATOM   2936 C  CB  . ASN A 1 419 ? 6.224   -25.135 -23.106 1.00 43.06  ? 682  ASN A CB  1 
ATOM   2937 C  CG  . ASN A 1 419 ? 6.637   -26.565 -22.805 1.00 42.15  ? 682  ASN A CG  1 
ATOM   2938 O  OD1 . ASN A 1 419 ? 5.897   -27.343 -22.207 1.00 43.95  ? 682  ASN A OD1 1 
ATOM   2939 N  ND2 . ASN A 1 419 ? 7.817   -26.939 -23.239 1.00 43.05  ? 682  ASN A ND2 1 
ATOM   2940 N  N   . ASP A 1 420 ? 4.412   -22.614 -24.002 1.00 37.53  ? 683  ASP A N   1 
ATOM   2941 C  CA  . ASP A 1 420 ? 4.064   -21.176 -23.847 1.00 43.80  ? 683  ASP A CA  1 
ATOM   2942 C  C   . ASP A 1 420 ? 2.535   -20.967 -23.742 1.00 47.65  ? 683  ASP A C   1 
ATOM   2943 O  O   . ASP A 1 420 ? 2.130   -20.006 -23.103 1.00 39.47  ? 683  ASP A O   1 
ATOM   2944 C  CB  . ASP A 1 420 ? 4.583   -20.315 -25.001 1.00 44.30  ? 683  ASP A CB  1 
ATOM   2945 C  CG  . ASP A 1 420 ? 4.494   -18.825 -24.658 1.00 51.03  ? 683  ASP A CG  1 
ATOM   2946 O  OD1 . ASP A 1 420 ? 4.910   -18.495 -23.539 1.00 44.24  ? 683  ASP A OD1 1 
ATOM   2947 O  OD2 . ASP A 1 420 ? 3.954   -17.998 -25.489 1.00 47.15  ? 683  ASP A OD2 1 
ATOM   2948 N  N   . MET A 1 421 ? 1.704   -21.826 -24.342 1.00 44.92  ? 684  MET A N   1 
ATOM   2949 C  CA  . MET A 1 421 ? 0.229   -21.734 -24.171 1.00 43.69  ? 684  MET A CA  1 
ATOM   2950 C  C   . MET A 1 421 ? -0.121  -22.174 -22.746 1.00 42.68  ? 684  MET A C   1 
ATOM   2951 O  O   . MET A 1 421 ? -1.263  -21.996 -22.335 1.00 43.72  ? 684  MET A O   1 
ATOM   2952 C  CB  . MET A 1 421 ? -0.486  -22.595 -25.217 1.00 44.07  ? 684  MET A CB  1 
ATOM   2953 C  CG  . MET A 1 421 ? -0.402  -21.990 -26.599 1.00 41.27  ? 684  MET A CG  1 
ATOM   2954 S  SD  . MET A 1 421 ? -1.223  -22.960 -27.893 1.00 47.56  ? 684  MET A SD  1 
ATOM   2955 C  CE  . MET A 1 421 ? -0.309  -24.495 -27.920 1.00 55.31  ? 684  MET A CE  1 
ATOM   2956 N  N   . GLY A 1 422 ? 0.818   -22.785 -22.033 1.00 37.71  ? 685  GLY A N   1 
ATOM   2957 C  CA  . GLY A 1 422 ? 0.603   -23.326 -20.669 1.00 36.56  ? 685  GLY A CA  1 
ATOM   2958 C  C   . GLY A 1 422 ? 0.075   -24.750 -20.635 1.00 36.58  ? 685  GLY A C   1 
ATOM   2959 O  O   . GLY A 1 422 ? -0.215  -25.229 -19.538 1.00 38.82  ? 685  GLY A O   1 
ATOM   2960 N  N   . LYS A 1 423 ? 0.017   -25.439 -21.775 1.00 41.55  ? 686  LYS A N   1 
ATOM   2961 C  CA  . LYS A 1 423 ? -0.454  -26.847 -21.899 1.00 42.52  ? 686  LYS A CA  1 
ATOM   2962 C  C   . LYS A 1 423 ? 0.764   -27.765 -21.732 1.00 46.02  ? 686  LYS A C   1 
ATOM   2963 O  O   . LYS A 1 423 ? 1.134   -28.538 -22.670 1.00 41.44  ? 686  LYS A O   1 
ATOM   2964 C  CB  . LYS A 1 423 ? -1.243  -27.009 -23.201 1.00 41.00  ? 686  LYS A CB  1 
ATOM   2965 C  CG  . LYS A 1 423 ? -2.367  -25.983 -23.353 1.00 40.13  ? 686  LYS A CG  1 
ATOM   2966 C  CD  . LYS A 1 423 ? -3.197  -25.841 -22.085 1.00 46.22  ? 686  LYS A CD  1 
ATOM   2967 C  CE  . LYS A 1 423 ? -4.392  -24.923 -22.214 1.00 47.76  ? 686  LYS A CE  1 
ATOM   2968 N  NZ  . LYS A 1 423 ? -3.947  -23.547 -22.525 1.00 51.19  ? 686  LYS A NZ  1 
ATOM   2969 N  N   . VAL A 1 424 ? 1.384   -27.685 -20.554 0.50 45.45  ? 687  VAL A N   1 
ATOM   2970 C  CA  . VAL A 1 424 ? 2.635   -28.419 -20.211 0.50 45.97  ? 687  VAL A CA  1 
ATOM   2971 C  C   . VAL A 1 424 ? 2.279   -29.890 -19.976 0.50 43.30  ? 687  VAL A C   1 
ATOM   2972 O  O   . VAL A 1 424 ? 1.333   -30.159 -19.209 0.50 46.92  ? 687  VAL A O   1 
ATOM   2973 C  CB  . VAL A 1 424 ? 3.335   -27.784 -18.994 0.50 47.74  ? 687  VAL A CB  1 
ATOM   2974 C  CG1 . VAL A 1 424 ? 4.647   -28.483 -18.671 0.50 49.23  ? 687  VAL A CG1 1 
ATOM   2975 C  CG2 . VAL A 1 424 ? 3.556   -26.293 -19.202 0.50 47.40  ? 687  VAL A CG2 1 
ATOM   2976 N  N   . ARG A 1 425 ? 3.019   -30.785 -20.636 1.00 41.70  ? 688  ARG A N   1 
ATOM   2977 C  CA  . ARG A 1 425 ? 2.772   -32.240 -20.666 1.00 40.90  ? 688  ARG A CA  1 
ATOM   2978 C  C   . ARG A 1 425 ? 2.965   -32.810 -19.258 1.00 43.45  ? 688  ARG A C   1 
ATOM   2979 O  O   . ARG A 1 425 ? 3.770   -32.264 -18.493 1.00 47.76  ? 688  ARG A O   1 
ATOM   2980 C  CB  . ARG A 1 425 ? 3.679   -32.905 -21.706 1.00 36.73  ? 688  ARG A CB  1 
ATOM   2981 C  CG  . ARG A 1 425 ? 3.430   -32.458 -23.130 1.00 36.83  ? 688  ARG A CG  1 
ATOM   2982 C  CD  . ARG A 1 425 ? 4.546   -32.835 -24.097 1.00 39.17  ? 688  ARG A CD  1 
ATOM   2983 N  NE  . ARG A 1 425 ? 5.780   -32.238 -23.651 1.00 40.77  ? 688  ARG A NE  1 
ATOM   2984 C  CZ  . ARG A 1 425 ? 6.996   -32.730 -23.848 1.00 39.36  ? 688  ARG A CZ  1 
ATOM   2985 N  NH1 . ARG A 1 425 ? 7.180   -33.784 -24.618 1.00 38.05  ? 688  ARG A NH1 1 
ATOM   2986 N  NH2 . ARG A 1 425 ? 8.036   -32.107 -23.318 1.00 42.59  ? 688  ARG A NH2 1 
ATOM   2987 N  N   . LYS A 1 426 ? 2.227   -33.878 -18.932 0.50 45.73  ? 689  LYS A N   1 
ATOM   2988 C  CA  . LYS A 1 426 ? 2.281   -34.593 -17.626 0.50 48.37  ? 689  LYS A CA  1 
ATOM   2989 C  C   . LYS A 1 426 ? 3.387   -35.660 -17.659 0.50 50.74  ? 689  LYS A C   1 
ATOM   2990 O  O   . LYS A 1 426 ? 3.518   -36.335 -18.695 0.50 51.04  ? 689  LYS A O   1 
ATOM   2991 C  CB  . LYS A 1 426 ? 0.928   -35.241 -17.319 0.50 51.69  ? 689  LYS A CB  1 
ATOM   2992 C  CG  . LYS A 1 426 ? 0.932   -36.236 -16.165 0.50 54.53  ? 689  LYS A CG  1 
ATOM   2993 C  CD  . LYS A 1 426 ? -0.397  -36.350 -15.449 0.50 55.97  ? 689  LYS A CD  1 
ATOM   2994 C  CE  . LYS A 1 426 ? -1.554  -36.606 -16.389 0.50 57.46  ? 689  LYS A CE  1 
ATOM   2995 N  NZ  . LYS A 1 426 ? -2.839  -36.688 -15.656 0.50 60.39  ? 689  LYS A NZ  1 
ATOM   2996 N  N   . ASP A 1 427 ? 4.134   -35.808 -16.558 1.00 51.80  ? 690  ASP A N   1 
ATOM   2997 C  CA  . ASP A 1 427 ? 5.156   -36.886 -16.373 1.00 52.32  ? 690  ASP A CA  1 
ATOM   2998 C  C   . ASP A 1 427 ? 6.218   -36.976 -17.485 1.00 55.18  ? 690  ASP A C   1 
ATOM   2999 O  O   . ASP A 1 427 ? 6.442   -38.089 -18.007 1.00 57.53  ? 690  ASP A O   1 
ATOM   3000 C  CB  . ASP A 1 427 ? 4.464   -38.241 -16.336 1.00 57.67  ? 690  ASP A CB  1 
ATOM   3001 C  CG  . ASP A 1 427 ? 3.562   -38.391 -15.140 1.00 63.49  ? 690  ASP A CG  1 
ATOM   3002 O  OD1 . ASP A 1 427 ? 3.751   -37.618 -14.151 1.00 65.46  ? 690  ASP A OD1 1 
ATOM   3003 O  OD2 . ASP A 1 427 ? 2.674   -39.260 -15.220 1.00 74.50  ? 690  ASP A OD2 1 
ATOM   3004 N  N   . ILE A 1 428 ? 6.792   -35.851 -17.892 1.00 49.61  ? 691  ILE A N   1 
ATOM   3005 C  CA  . ILE A 1 428 ? 7.930   -35.784 -18.852 1.00 47.05  ? 691  ILE A CA  1 
ATOM   3006 C  C   . ILE A 1 428 ? 8.527   -34.403 -18.666 1.00 47.34  ? 691  ILE A C   1 
ATOM   3007 O  O   . ILE A 1 428 ? 7.751   -33.511 -18.358 1.00 50.06  ? 691  ILE A O   1 
ATOM   3008 C  CB  . ILE A 1 428 ? 7.519   -36.023 -20.314 1.00 46.92  ? 691  ILE A CB  1 
ATOM   3009 C  CG1 . ILE A 1 428 ? 8.754   -36.097 -21.207 1.00 47.35  ? 691  ILE A CG1 1 
ATOM   3010 C  CG2 . ILE A 1 428 ? 6.558   -34.963 -20.821 1.00 48.06  ? 691  ILE A CG2 1 
ATOM   3011 C  CD1 . ILE A 1 428 ? 8.512   -36.800 -22.505 1.00 48.85  ? 691  ILE A CD1 1 
ATOM   3012 N  N   . GLN A 1 429 ? 9.845   -34.256 -18.729 1.00 46.26  ? 692  GLN A N   1 
ATOM   3013 C  CA  . GLN A 1 429 ? 10.496  -32.954 -18.452 1.00 46.80  ? 692  GLN A CA  1 
ATOM   3014 C  C   . GLN A 1 429 ? 10.106  -31.989 -19.575 1.00 43.15  ? 692  GLN A C   1 
ATOM   3015 O  O   . GLN A 1 429 ? 9.912   -32.399 -20.741 1.00 43.36  ? 692  GLN A O   1 
ATOM   3016 C  CB  . GLN A 1 429 ? 12.015  -33.101 -18.311 1.00 61.13  ? 692  GLN A CB  1 
ATOM   3017 C  CG  . GLN A 1 429 ? 12.458  -34.112 -17.252 1.00 77.62  ? 692  GLN A CG  1 
ATOM   3018 C  CD  . GLN A 1 429 ? 13.921  -34.493 -17.373 1.00 92.84  ? 692  GLN A CD  1 
ATOM   3019 O  OE1 . GLN A 1 429 ? 14.347  -35.101 -18.359 1.00 92.38  ? 692  GLN A OE1 1 
ATOM   3020 N  NE2 . GLN A 1 429 ? 14.712  -34.152 -16.362 1.00 92.30  ? 692  GLN A NE2 1 
ATOM   3021 N  N   . GLN A 1 430 ? 10.096  -30.721 -19.240 1.00 47.01  ? 693  GLN A N   1 
ATOM   3022 C  CA  . GLN A 1 430 ? 9.466   -29.659 -20.047 1.00 52.84  ? 693  GLN A CA  1 
ATOM   3023 C  C   . GLN A 1 430 ? 9.954   -29.709 -21.481 1.00 49.65  ? 693  GLN A C   1 
ATOM   3024 O  O   . GLN A 1 430 ? 9.096   -29.523 -22.344 1.00 52.59  ? 693  GLN A O   1 
ATOM   3025 C  CB  . GLN A 1 430 ? 9.738   -28.280 -19.463 1.00 58.10  ? 693  GLN A CB  1 
ATOM   3026 C  CG  . GLN A 1 430 ? 8.680   -27.286 -19.890 1.00 74.48  ? 693  GLN A CG  1 
ATOM   3027 C  CD  . GLN A 1 430 ? 8.680   -26.061 -19.019 1.00 76.12  ? 693  GLN A CD  1 
ATOM   3028 O  OE1 . GLN A 1 430 ? 9.722   -25.614 -18.546 1.00 82.73  ? 693  GLN A OE1 1 
ATOM   3029 N  NE2 . GLN A 1 430 ? 7.496   -25.517 -18.805 1.00 76.10  ? 693  GLN A NE2 1 
ATOM   3030 N  N   . TRP A 1 431 ? 11.255  -29.941 -21.721 1.00 49.37  ? 694  TRP A N   1 
ATOM   3031 C  CA  . TRP A 1 431 ? 11.902  -29.787 -23.058 1.00 47.64  ? 694  TRP A CA  1 
ATOM   3032 C  C   . TRP A 1 431 ? 12.359  -31.136 -23.622 1.00 45.13  ? 694  TRP A C   1 
ATOM   3033 O  O   . TRP A 1 431 ? 12.958  -31.140 -24.691 1.00 47.41  ? 694  TRP A O   1 
ATOM   3034 C  CB  . TRP A 1 431 ? 13.041  -28.757 -23.007 1.00 54.24  ? 694  TRP A CB  1 
ATOM   3035 C  CG  . TRP A 1 431 ? 12.565  -27.409 -22.552 1.00 57.42  ? 694  TRP A CG  1 
ATOM   3036 C  CD1 . TRP A 1 431 ? 12.767  -26.821 -21.335 1.00 57.33  ? 694  TRP A CD1 1 
ATOM   3037 C  CD2 . TRP A 1 431 ? 11.698  -26.521 -23.286 1.00 57.97  ? 694  TRP A CD2 1 
ATOM   3038 N  NE1 . TRP A 1 431 ? 12.117  -25.612 -21.285 1.00 60.40  ? 694  TRP A NE1 1 
ATOM   3039 C  CE2 . TRP A 1 431 ? 11.477  -25.391 -22.472 1.00 56.96  ? 694  TRP A CE2 1 
ATOM   3040 C  CE3 . TRP A 1 431 ? 11.126  -26.553 -24.565 1.00 49.58  ? 694  TRP A CE3 1 
ATOM   3041 C  CZ2 . TRP A 1 431 ? 10.660  -24.337 -22.879 1.00 55.50  ? 694  TRP A CZ2 1 
ATOM   3042 C  CZ3 . TRP A 1 431 ? 10.355  -25.494 -24.978 1.00 50.90  ? 694  TRP A CZ3 1 
ATOM   3043 C  CH2 . TRP A 1 431 ? 10.121  -24.408 -24.143 1.00 50.97  ? 694  TRP A CH2 1 
ATOM   3044 N  N   . GLU A 1 432 ? 11.967  -32.232 -22.982 1.00 45.33  ? 695  GLU A N   1 
ATOM   3045 C  CA  . GLU A 1 432 ? 12.248  -33.604 -23.459 1.00 46.95  ? 695  GLU A CA  1 
ATOM   3046 C  C   . GLU A 1 432 ? 11.248  -33.939 -24.568 1.00 44.38  ? 695  GLU A C   1 
ATOM   3047 O  O   . GLU A 1 432 ? 10.042  -33.803 -24.406 1.00 39.73  ? 695  GLU A O   1 
ATOM   3048 C  CB  . GLU A 1 432 ? 12.214  -34.522 -22.233 1.00 50.55  ? 695  GLU A CB  1 
ATOM   3049 C  CG  . GLU A 1 432 ? 12.595  -35.956 -22.526 1.00 62.65  ? 695  GLU A CG  1 
ATOM   3050 C  CD  . GLU A 1 432 ? 14.044  -36.178 -22.956 1.00 71.84  ? 695  GLU A CD  1 
ATOM   3051 O  OE1 . GLU A 1 432 ? 14.283  -37.198 -23.646 1.00 67.28  ? 695  GLU A OE1 1 
ATOM   3052 O  OE2 . GLU A 1 432 ? 14.937  -35.341 -22.597 1.00 69.89  ? 695  GLU A OE2 1 
ATOM   3053 N  N   . PRO A 1 433 ? 11.693  -34.404 -25.743 1.00 42.83  ? 696  PRO A N   1 
ATOM   3054 C  CA  . PRO A 1 433 ? 10.762  -34.702 -26.831 1.00 38.41  ? 696  PRO A CA  1 
ATOM   3055 C  C   . PRO A 1 433 ? 9.759   -35.792 -26.471 1.00 38.43  ? 696  PRO A C   1 
ATOM   3056 O  O   . PRO A 1 433 ? 10.085  -36.643 -25.709 1.00 35.96  ? 696  PRO A O   1 
ATOM   3057 C  CB  . PRO A 1 433 ? 11.644  -35.205 -27.976 1.00 42.24  ? 696  PRO A CB  1 
ATOM   3058 C  CG  . PRO A 1 433 ? 13.040  -34.664 -27.601 1.00 48.32  ? 696  PRO A CG  1 
ATOM   3059 C  CD  . PRO A 1 433 ? 13.085  -34.724 -26.088 1.00 42.53  ? 696  PRO A CD  1 
ATOM   3060 N  N   . SER A 1 434 ? 8.542   -35.699 -27.006 1.00 36.40  ? 697  SER A N   1 
ATOM   3061 C  CA  . SER A 1 434 ? 7.457   -36.667 -26.763 1.00 32.71  ? 697  SER A CA  1 
ATOM   3062 C  C   . SER A 1 434 ? 7.885   -38.043 -27.284 1.00 34.40  ? 697  SER A C   1 
ATOM   3063 O  O   . SER A 1 434 ? 8.478   -38.091 -28.371 1.00 39.76  ? 697  SER A O   1 
ATOM   3064 C  CB  . SER A 1 434 ? 6.196   -36.193 -27.475 1.00 32.10  ? 697  SER A CB  1 
ATOM   3065 O  OG  . SER A 1 434 ? 5.684   -35.025 -26.861 1.00 28.74  ? 697  SER A OG  1 
ATOM   3066 N  N   . ARG A 1 435 ? 7.510   -39.107 -26.582 1.00 38.16  ? 698  ARG A N   1 
ATOM   3067 C  CA  . ARG A 1 435 ? 7.611   -40.522 -27.032 1.00 42.60  ? 698  ARG A CA  1 
ATOM   3068 C  C   . ARG A 1 435 ? 6.293   -40.904 -27.702 1.00 43.67  ? 698  ARG A C   1 
ATOM   3069 O  O   . ARG A 1 435 ? 5.263   -40.923 -27.015 1.00 47.29  ? 698  ARG A O   1 
ATOM   3070 C  CB  . ARG A 1 435 ? 7.859   -41.443 -25.832 1.00 50.54  ? 698  ARG A CB  1 
ATOM   3071 C  CG  . ARG A 1 435 ? 9.231   -41.226 -25.201 1.00 63.21  ? 698  ARG A CG  1 
ATOM   3072 C  CD  . ARG A 1 435 ? 9.526   -42.142 -24.031 1.00 76.27  ? 698  ARG A CD  1 
ATOM   3073 N  NE  . ARG A 1 435 ? 8.932   -41.669 -22.784 1.00 89.26  ? 698  ARG A NE  1 
ATOM   3074 C  CZ  . ARG A 1 435 ? 9.410   -40.677 -22.018 1.00 95.09  ? 698  ARG A CZ  1 
ATOM   3075 N  NH1 . ARG A 1 435 ? 10.505  -40.012 -22.364 1.00 89.61  ? 698  ARG A NH1 1 
ATOM   3076 N  NH2 . ARG A 1 435 ? 8.774   -40.349 -20.901 1.00 88.36  ? 698  ARG A NH2 1 
ATOM   3077 N  N   . GLY A 1 436 ? 6.331   -41.166 -28.992 1.00 36.93  ? 699  GLY A N   1 
ATOM   3078 C  CA  . GLY A 1 436 ? 5.156   -41.564 -29.780 1.00 43.72  ? 699  GLY A CA  1 
ATOM   3079 C  C   . GLY A 1 436 ? 4.981   -43.068 -29.819 1.00 39.88  ? 699  GLY A C   1 
ATOM   3080 O  O   . GLY A 1 436 ? 5.820   -43.778 -29.298 1.00 40.73  ? 699  GLY A O   1 
ATOM   3081 N  N   . TRP A 1 437 ? 3.918   -43.533 -30.465 1.00 38.33  ? 700  TRP A N   1 
ATOM   3082 C  CA  . TRP A 1 437 ? 3.571   -44.966 -30.511 1.00 32.51  ? 700  TRP A CA  1 
ATOM   3083 C  C   . TRP A 1 437 ? 3.681   -45.409 -31.957 1.00 33.35  ? 700  TRP A C   1 
ATOM   3084 O  O   . TRP A 1 437 ? 3.182   -44.685 -32.840 1.00 32.14  ? 700  TRP A O   1 
ATOM   3085 C  CB  . TRP A 1 437 ? 2.153   -45.159 -29.983 1.00 34.89  ? 700  TRP A CB  1 
ATOM   3086 C  CG  . TRP A 1 437 ? 1.929   -44.702 -28.578 1.00 29.20  ? 700  TRP A CG  1 
ATOM   3087 C  CD1 . TRP A 1 437 ? 1.600   -43.459 -28.145 1.00 31.40  ? 700  TRP A CD1 1 
ATOM   3088 C  CD2 . TRP A 1 437 ? 2.056   -45.506 -27.405 1.00 26.42  ? 700  TRP A CD2 1 
ATOM   3089 N  NE1 . TRP A 1 437 ? 1.571   -43.424 -26.779 1.00 30.59  ? 700  TRP A NE1 1 
ATOM   3090 C  CE2 . TRP A 1 437 ? 1.804   -44.678 -26.303 1.00 28.57  ? 700  TRP A CE2 1 
ATOM   3091 C  CE3 . TRP A 1 437 ? 2.389   -46.827 -27.199 1.00 29.42  ? 700  TRP A CE3 1 
ATOM   3092 C  CZ2 . TRP A 1 437 ? 1.775   -45.146 -25.004 1.00 27.68  ? 700  TRP A CZ2 1 
ATOM   3093 C  CZ3 . TRP A 1 437 ? 2.396   -47.293 -25.915 1.00 31.57  ? 700  TRP A CZ3 1 
ATOM   3094 C  CH2 . TRP A 1 437 ? 2.099   -46.464 -24.836 1.00 30.42  ? 700  TRP A CH2 1 
ATOM   3095 N  N   . ASN A 1 438 ? 4.242   -46.569 -32.206 1.00 30.53  ? 701  ASN A N   1 
ATOM   3096 C  CA  . ASN A 1 438 ? 4.328   -47.093 -33.591 1.00 35.56  ? 701  ASN A CA  1 
ATOM   3097 C  C   . ASN A 1 438 ? 3.114   -47.955 -33.912 1.00 40.01  ? 701  ASN A C   1 
ATOM   3098 O  O   . ASN A 1 438 ? 2.906   -48.179 -35.087 1.00 38.22  ? 701  ASN A O   1 
ATOM   3099 C  CB  . ASN A 1 438 ? 5.640   -47.858 -33.763 1.00 40.82  ? 701  ASN A CB  1 
ATOM   3100 C  CG  . ASN A 1 438 ? 6.794   -46.892 -33.576 1.00 51.16  ? 701  ASN A CG  1 
ATOM   3101 O  OD1 . ASN A 1 438 ? 7.590   -47.029 -32.636 1.00 63.73  ? 701  ASN A OD1 1 
ATOM   3102 N  ND2 . ASN A 1 438 ? 6.787   -45.838 -34.389 1.00 42.83  ? 701  ASN A ND2 1 
ATOM   3103 N  N   . ASP A 1 439 ? 2.370   -48.435 -32.910 1.00 39.94  ? 702  ASP A N   1 
ATOM   3104 C  CA  . ASP A 1 439 ? 1.218   -49.350 -33.132 1.00 44.69  ? 702  ASP A CA  1 
ATOM   3105 C  C   . ASP A 1 439 ? -0.070  -48.687 -32.586 1.00 37.00  ? 702  ASP A C   1 
ATOM   3106 O  O   . ASP A 1 439 ? -0.167  -48.413 -31.368 1.00 35.05  ? 702  ASP A O   1 
ATOM   3107 C  CB  . ASP A 1 439 ? 1.615   -50.710 -32.546 1.00 44.75  ? 702  ASP A CB  1 
ATOM   3108 C  CG  . ASP A 1 439 ? 0.528   -51.772 -32.462 1.00 51.95  ? 702  ASP A CG  1 
ATOM   3109 O  OD1 . ASP A 1 439 ? -0.536  -51.620 -33.135 1.00 50.95  ? 702  ASP A OD1 1 
ATOM   3110 O  OD2 . ASP A 1 439 ? 0.765   -52.758 -31.714 1.00 52.75  ? 702  ASP A OD2 1 
ATOM   3111 N  N   . TRP A 1 440 ? -1.054  -48.451 -33.444 1.00 38.63  ? 703  TRP A N   1 
ATOM   3112 C  CA  . TRP A 1 440 ? -2.348  -47.846 -33.033 1.00 33.79  ? 703  TRP A CA  1 
ATOM   3113 C  C   . TRP A 1 440 ? -3.032  -48.683 -31.940 1.00 31.51  ? 703  TRP A C   1 
ATOM   3114 O  O   . TRP A 1 440 ? -3.762  -48.118 -31.148 1.00 37.44  ? 703  TRP A O   1 
ATOM   3115 C  CB  . TRP A 1 440 ? -3.225  -47.611 -34.246 1.00 34.17  ? 703  TRP A CB  1 
ATOM   3116 C  CG  . TRP A 1 440 ? -3.762  -48.851 -34.890 1.00 37.94  ? 703  TRP A CG  1 
ATOM   3117 C  CD1 . TRP A 1 440 ? -3.228  -49.531 -35.947 1.00 41.69  ? 703  TRP A CD1 1 
ATOM   3118 C  CD2 . TRP A 1 440 ? -4.975  -49.530 -34.558 1.00 38.34  ? 703  TRP A CD2 1 
ATOM   3119 N  NE1 . TRP A 1 440 ? -4.034  -50.573 -36.308 1.00 39.33  ? 703  TRP A NE1 1 
ATOM   3120 C  CE2 . TRP A 1 440 ? -5.093  -50.625 -35.445 1.00 42.83  ? 703  TRP A CE2 1 
ATOM   3121 C  CE3 . TRP A 1 440 ? -5.970  -49.322 -33.607 1.00 37.45  ? 703  TRP A CE3 1 
ATOM   3122 C  CZ2 . TRP A 1 440 ? -6.169  -51.510 -35.405 1.00 39.00  ? 703  TRP A CZ2 1 
ATOM   3123 C  CZ3 . TRP A 1 440 ? -7.024  -50.204 -33.560 1.00 36.86  ? 703  TRP A CZ3 1 
ATOM   3124 C  CH2 . TRP A 1 440 ? -7.119  -51.276 -34.447 1.00 40.20  ? 703  TRP A CH2 1 
ATOM   3125 N  N   . THR A 1 441 ? -2.740  -49.967 -31.832 1.00 30.54  ? 704  THR A N   1 
ATOM   3126 C  CA  . THR A 1 441 ? -3.351  -50.875 -30.833 1.00 30.41  ? 704  THR A CA  1 
ATOM   3127 C  C   . THR A 1 441 ? -2.763  -50.726 -29.430 1.00 31.37  ? 704  THR A C   1 
ATOM   3128 O  O   . THR A 1 441 ? -3.296  -51.365 -28.498 1.00 34.40  ? 704  THR A O   1 
ATOM   3129 C  CB  . THR A 1 441 ? -3.332  -52.336 -31.298 1.00 32.70  ? 704  THR A CB  1 
ATOM   3130 O  OG1 . THR A 1 441 ? -2.001  -52.877 -31.272 1.00 31.30  ? 704  THR A OG1 1 
ATOM   3131 C  CG2 . THR A 1 441 ? -3.946  -52.500 -32.675 1.00 30.54  ? 704  THR A CG2 1 
ATOM   3132 N  N   . GLN A 1 442 ? -1.701  -49.928 -29.244 0.46 29.49  ? 705  GLN A N   1 
ATOM   3133 C  CA  . GLN A 1 442 ? -1.111  -49.658 -27.900 0.46 29.01  ? 705  GLN A CA  1 
ATOM   3134 C  C   . GLN A 1 442 ? -1.346  -48.203 -27.465 0.46 28.40  ? 705  GLN A C   1 
ATOM   3135 O  O   . GLN A 1 442 ? -1.021  -47.887 -26.310 0.46 27.48  ? 705  GLN A O   1 
ATOM   3136 C  CB  . GLN A 1 442 ? 0.387   -49.984 -27.881 0.46 30.70  ? 705  GLN A CB  1 
ATOM   3137 C  CG  . GLN A 1 442 ? 0.688   -51.475 -27.801 0.46 29.12  ? 705  GLN A CG  1 
ATOM   3138 C  CD  . GLN A 1 442 ? 2.165   -51.763 -27.680 0.46 27.77  ? 705  GLN A CD  1 
ATOM   3139 O  OE1 . GLN A 1 442 ? 2.809   -51.433 -26.685 0.46 27.29  ? 705  GLN A OE1 1 
ATOM   3140 N  NE2 . GLN A 1 442 ? 2.713   -52.421 -28.688 0.46 28.05  ? 705  GLN A NE2 1 
ATOM   3141 N  N   . VAL A 1 443 ? -1.878  -47.347 -28.342 1.00 29.79  ? 706  VAL A N   1 
ATOM   3142 C  CA  . VAL A 1 443 ? -2.172  -45.922 -28.017 1.00 32.52  ? 706  VAL A CA  1 
ATOM   3143 C  C   . VAL A 1 443 ? -3.240  -45.840 -26.939 1.00 28.74  ? 706  VAL A C   1 
ATOM   3144 O  O   . VAL A 1 443 ? -4.260  -46.478 -27.066 1.00 31.41  ? 706  VAL A O   1 
ATOM   3145 C  CB  . VAL A 1 443 ? -2.654  -45.177 -29.269 1.00 33.04  ? 706  VAL A CB  1 
ATOM   3146 C  CG1 . VAL A 1 443 ? -3.037  -43.746 -28.978 1.00 38.27  ? 706  VAL A CG1 1 
ATOM   3147 C  CG2 . VAL A 1 443 ? -1.594  -45.221 -30.323 1.00 37.21  ? 706  VAL A CG2 1 
ATOM   3148 N  N   . PRO A 1 444 ? -3.019  -45.080 -25.841 1.00 26.22  ? 707  PRO A N   1 
ATOM   3149 C  CA  . PRO A 1 444 ? -4.079  -44.810 -24.887 1.00 28.66  ? 707  PRO A CA  1 
ATOM   3150 C  C   . PRO A 1 444 ? -5.017  -43.699 -25.405 1.00 29.96  ? 707  PRO A C   1 
ATOM   3151 O  O   . PRO A 1 444 ? -4.516  -42.734 -25.956 1.00 29.35  ? 707  PRO A O   1 
ATOM   3152 C  CB  . PRO A 1 444 ? -3.336  -44.323 -23.653 1.00 30.09  ? 707  PRO A CB  1 
ATOM   3153 C  CG  . PRO A 1 444 ? -2.029  -43.710 -24.207 1.00 31.78  ? 707  PRO A CG  1 
ATOM   3154 C  CD  . PRO A 1 444 ? -1.791  -44.324 -25.577 1.00 27.82  ? 707  PRO A CD  1 
ATOM   3155 N  N   . PHE A 1 445 ? -6.339  -43.812 -25.171 1.00 28.08  ? 708  PHE A N   1 
ATOM   3156 C  CA  . PHE A 1 445 ? -7.325  -42.754 -25.504 1.00 28.44  ? 708  PHE A CA  1 
ATOM   3157 C  C   . PHE A 1 445 ? -8.604  -43.001 -24.729 1.00 29.09  ? 708  PHE A C   1 
ATOM   3158 O  O   . PHE A 1 445 ? -9.092  -44.162 -24.786 1.00 26.46  ? 708  PHE A O   1 
ATOM   3159 C  CB  . PHE A 1 445 ? -7.642  -42.771 -27.004 1.00 28.45  ? 708  PHE A CB  1 
ATOM   3160 C  CG  . PHE A 1 445 ? -8.524  -41.647 -27.499 1.00 29.88  ? 708  PHE A CG  1 
ATOM   3161 C  CD1 . PHE A 1 445 ? -8.241  -40.334 -27.180 1.00 30.53  ? 708  PHE A CD1 1 
ATOM   3162 C  CD2 . PHE A 1 445 ? -9.613  -41.903 -28.326 1.00 31.38  ? 708  PHE A CD2 1 
ATOM   3163 C  CE1 . PHE A 1 445 ? -9.005  -39.286 -27.678 1.00 31.50  ? 708  PHE A CE1 1 
ATOM   3164 C  CE2 . PHE A 1 445 ? -10.355 -40.857 -28.863 1.00 35.12  ? 708  PHE A CE2 1 
ATOM   3165 C  CZ  . PHE A 1 445 ? -10.064 -39.545 -28.522 1.00 33.09  ? 708  PHE A CZ  1 
ATOM   3166 N  N   . CYS A 1 446 ? -9.086  -41.989 -24.007 1.00 29.21  ? 709  CYS A N   1 
ATOM   3167 C  CA  . CYS A 1 446 ? -10.348 -42.075 -23.207 1.00 29.95  ? 709  CYS A CA  1 
ATOM   3168 C  C   . CYS A 1 446 ? -10.283 -43.288 -22.267 1.00 28.14  ? 709  CYS A C   1 
ATOM   3169 O  O   . CYS A 1 446 ? -11.292 -44.052 -22.162 1.00 30.35  ? 709  CYS A O   1 
ATOM   3170 C  CB  . CYS A 1 446 ? -11.574 -42.111 -24.111 1.00 28.80  ? 709  CYS A CB  1 
ATOM   3171 S  SG  . CYS A 1 446 ? -11.694 -40.660 -25.213 1.00 35.80  ? 709  CYS A SG  1 
ATOM   3172 N  N   . SER A 1 447 ? -9.117  -43.502 -21.653 1.00 29.90  ? 710  SER A N   1 
ATOM   3173 C  CA  . SER A 1 447 ? -8.893  -44.490 -20.566 1.00 30.72  ? 710  SER A CA  1 
ATOM   3174 C  C   . SER A 1 447 ? -8.883  -45.916 -21.128 1.00 29.43  ? 710  SER A C   1 
ATOM   3175 O  O   . SER A 1 447 ? -8.894  -46.855 -20.331 1.00 31.38  ? 710  SER A O   1 
ATOM   3176 C  CB  . SER A 1 447 ? -9.945  -44.346 -19.509 1.00 36.45  ? 710  SER A CB  1 
ATOM   3177 O  OG  . SER A 1 447 ? -9.851  -43.081 -18.870 1.00 40.87  ? 710  SER A OG  1 
ATOM   3178 N  N   . HIS A 1 448 ? -8.760  -46.080 -22.439 1.00 27.53  ? 711  HIS A N   1 
ATOM   3179 C  CA  . HIS A 1 448 ? -8.757  -47.400 -23.108 1.00 27.17  ? 711  HIS A CA  1 
ATOM   3180 C  C   . HIS A 1 448 ? -7.546  -47.591 -24.048 1.00 24.69  ? 711  HIS A C   1 
ATOM   3181 O  O   . HIS A 1 448 ? -6.890  -46.627 -24.386 1.00 25.11  ? 711  HIS A O   1 
ATOM   3182 C  CB  . HIS A 1 448 ? -10.043 -47.530 -23.926 1.00 26.06  ? 711  HIS A CB  1 
ATOM   3183 C  CG  . HIS A 1 448 ? -11.236 -47.743 -23.059 1.00 28.78  ? 711  HIS A CG  1 
ATOM   3184 N  ND1 . HIS A 1 448 ? -11.790 -46.722 -22.317 1.00 31.02  ? 711  HIS A ND1 1 
ATOM   3185 C  CD2 . HIS A 1 448 ? -11.943 -48.857 -22.784 1.00 29.81  ? 711  HIS A CD2 1 
ATOM   3186 C  CE1 . HIS A 1 448 ? -12.794 -47.208 -21.605 1.00 33.49  ? 711  HIS A CE1 1 
ATOM   3187 N  NE2 . HIS A 1 448 ? -12.920 -48.515 -21.879 1.00 30.66  ? 711  HIS A NE2 1 
ATOM   3188 N  N   . HIS A 1 449 ? -7.335  -48.822 -24.475 1.00 24.96  ? 712  HIS A N   1 
ATOM   3189 C  CA  . HIS A 1 449 ? -6.678  -49.191 -25.743 1.00 28.31  ? 712  HIS A CA  1 
ATOM   3190 C  C   . HIS A 1 449 ? -7.628  -50.077 -26.543 1.00 29.43  ? 712  HIS A C   1 
ATOM   3191 O  O   . HIS A 1 449 ? -8.663  -50.463 -26.030 1.00 31.42  ? 712  HIS A O   1 
ATOM   3192 C  CB  . HIS A 1 449 ? -5.333  -49.895 -25.501 1.00 26.38  ? 712  HIS A CB  1 
ATOM   3193 C  CG  . HIS A 1 449 ? -5.484  -51.120 -24.669 1.00 24.19  ? 712  HIS A CG  1 
ATOM   3194 N  ND1 . HIS A 1 449 ? -5.572  -51.056 -23.311 1.00 22.50  ? 712  HIS A ND1 1 
ATOM   3195 C  CD2 . HIS A 1 449 ? -5.604  -52.418 -24.994 1.00 24.30  ? 712  HIS A CD2 1 
ATOM   3196 C  CE1 . HIS A 1 449 ? -5.764  -52.270 -22.816 1.00 22.06  ? 712  HIS A CE1 1 
ATOM   3197 N  NE2 . HIS A 1 449 ? -5.771  -53.124 -23.826 1.00 24.02  ? 712  HIS A NE2 1 
ATOM   3198 N  N   . PHE A 1 450 ? -7.231  -50.392 -27.764 1.00 29.05  ? 713  PHE A N   1 
ATOM   3199 C  CA  . PHE A 1 450 ? -8.087  -50.999 -28.779 1.00 29.45  ? 713  PHE A CA  1 
ATOM   3200 C  C   . PHE A 1 450 ? -7.358  -52.183 -29.395 1.00 29.68  ? 713  PHE A C   1 
ATOM   3201 O  O   . PHE A 1 450 ? -6.185  -52.102 -29.725 1.00 30.26  ? 713  PHE A O   1 
ATOM   3202 C  CB  . PHE A 1 450 ? -8.559  -49.933 -29.775 1.00 31.18  ? 713  PHE A CB  1 
ATOM   3203 C  CG  . PHE A 1 450 ? -9.273  -48.815 -29.066 1.00 31.28  ? 713  PHE A CG  1 
ATOM   3204 C  CD1 . PHE A 1 450 ? -8.559  -47.771 -28.513 1.00 30.86  ? 713  PHE A CD1 1 
ATOM   3205 C  CD2 . PHE A 1 450 ? -10.627 -48.906 -28.803 1.00 30.39  ? 713  PHE A CD2 1 
ATOM   3206 C  CE1 . PHE A 1 450 ? -9.208  -46.782 -27.794 1.00 30.16  ? 713  PHE A CE1 1 
ATOM   3207 C  CE2 . PHE A 1 450 ? -11.273 -47.909 -28.091 1.00 33.17  ? 713  PHE A CE2 1 
ATOM   3208 C  CZ  . PHE A 1 450 ? -10.559 -46.861 -27.568 1.00 32.47  ? 713  PHE A CZ  1 
ATOM   3209 N  N   . HIS A 1 451 ? -8.078  -53.305 -29.471 1.00 30.36  ? 714  HIS A N   1 
ATOM   3210 C  CA  . HIS A 1 451 ? -7.604  -54.558 -30.070 1.00 30.81  ? 714  HIS A CA  1 
ATOM   3211 C  C   . HIS A 1 451 ? -8.316  -54.751 -31.402 1.00 32.88  ? 714  HIS A C   1 
ATOM   3212 O  O   . HIS A 1 451 ? -9.502  -54.362 -31.539 1.00 31.85  ? 714  HIS A O   1 
ATOM   3213 C  CB  . HIS A 1 451 ? -7.852  -55.709 -29.094 1.00 32.15  ? 714  HIS A CB  1 
ATOM   3214 C  CG  . HIS A 1 451 ? -7.103  -55.706 -27.792 1.00 28.53  ? 714  HIS A CG  1 
ATOM   3215 N  ND1 . HIS A 1 451 ? -6.022  -56.533 -27.561 1.00 32.27  ? 714  HIS A ND1 1 
ATOM   3216 C  CD2 . HIS A 1 451 ? -7.325  -55.075 -26.616 1.00 31.42  ? 714  HIS A CD2 1 
ATOM   3217 C  CE1 . HIS A 1 451 ? -5.624  -56.402 -26.290 1.00 31.27  ? 714  HIS A CE1 1 
ATOM   3218 N  NE2 . HIS A 1 451 ? -6.428  -55.521 -25.663 1.00 20.65  ? 714  HIS A NE2 1 
ATOM   3219 N  N   . GLU A 1 452 ? -7.610  -55.377 -32.337 1.00 38.16  ? 715  GLU A N   1 
ATOM   3220 C  CA  . GLU A 1 452 ? -8.150  -55.876 -33.620 1.00 39.67  ? 715  GLU A CA  1 
ATOM   3221 C  C   . GLU A 1 452 ? -8.446  -57.364 -33.433 1.00 40.19  ? 715  GLU A C   1 
ATOM   3222 O  O   . GLU A 1 452 ? -7.585  -58.104 -32.976 1.00 41.22  ? 715  GLU A O   1 
ATOM   3223 C  CB  . GLU A 1 452 ? -7.163  -55.634 -34.749 1.00 42.00  ? 715  GLU A CB  1 
ATOM   3224 C  CG  . GLU A 1 452 ? -7.847  -55.225 -36.022 1.00 47.14  ? 715  GLU A CG  1 
ATOM   3225 C  CD  . GLU A 1 452 ? -6.904  -54.991 -37.187 1.00 55.70  ? 715  GLU A CD  1 
ATOM   3226 O  OE1 . GLU A 1 452 ? -7.199  -54.079 -38.015 1.00 53.91  ? 715  GLU A OE1 1 
ATOM   3227 O  OE2 . GLU A 1 452 ? -5.898  -55.748 -37.282 1.00 58.76  ? 715  GLU A OE2 1 
ATOM   3228 N  N   . LEU A 1 453 ? -9.658  -57.782 -33.742 1.00 36.81  ? 716  LEU A N   1 
ATOM   3229 C  CA  . LEU A 1 453 ? -10.157 -59.131 -33.382 1.00 39.38  ? 716  LEU A CA  1 
ATOM   3230 C  C   . LEU A 1 453 ? -10.914 -59.660 -34.588 1.00 39.09  ? 716  LEU A C   1 
ATOM   3231 O  O   . LEU A 1 453 ? -11.805 -58.947 -35.126 1.00 39.50  ? 716  LEU A O   1 
ATOM   3232 C  CB  . LEU A 1 453 ? -11.011 -58.934 -32.135 1.00 43.94  ? 716  LEU A CB  1 
ATOM   3233 C  CG  . LEU A 1 453 ? -11.669 -60.156 -31.544 1.00 54.48  ? 716  LEU A CG  1 
ATOM   3234 C  CD1 . LEU A 1 453 ? -10.673 -61.288 -31.395 1.00 63.68  ? 716  LEU A CD1 1 
ATOM   3235 C  CD2 . LEU A 1 453 ? -12.304 -59.787 -30.203 1.00 57.80  ? 716  LEU A CD2 1 
ATOM   3236 N  N   . ILE A 1 454 ? -10.451 -60.784 -35.095 1.00 42.99  ? 717  ILE A N   1 
ATOM   3237 C  CA  . ILE A 1 454 ? -10.989 -61.376 -36.349 1.00 41.39  ? 717  ILE A CA  1 
ATOM   3238 C  C   . ILE A 1 454 ? -12.004 -62.448 -35.956 1.00 39.32  ? 717  ILE A C   1 
ATOM   3239 O  O   . ILE A 1 454 ? -11.722 -63.296 -35.087 1.00 36.32  ? 717  ILE A O   1 
ATOM   3240 C  CB  . ILE A 1 454 ? -9.836  -61.874 -37.231 1.00 48.16  ? 717  ILE A CB  1 
ATOM   3241 C  CG1 . ILE A 1 454 ? -8.803  -60.756 -37.419 1.00 48.52  ? 717  ILE A CG1 1 
ATOM   3242 C  CG2 . ILE A 1 454 ? -10.353 -62.403 -38.568 1.00 49.25  ? 717  ILE A CG2 1 
ATOM   3243 C  CD1 . ILE A 1 454 ? -7.790  -61.042 -38.477 1.00 50.95  ? 717  ILE A CD1 1 
ATOM   3244 N  N   . MET A 1 455 ? -13.196 -62.327 -36.504 1.00 39.82  ? 718  MET A N   1 
ATOM   3245 C  CA  . MET A 1 455 ? -14.281 -63.306 -36.266 1.00 45.68  ? 718  MET A CA  1 
ATOM   3246 C  C   . MET A 1 455 ? -14.023 -64.548 -37.107 1.00 42.24  ? 718  MET A C   1 
ATOM   3247 O  O   . MET A 1 455 ? -13.390 -64.458 -38.178 1.00 42.12  ? 718  MET A O   1 
ATOM   3248 C  CB  . MET A 1 455 ? -15.643 -62.734 -36.657 1.00 40.59  ? 718  MET A CB  1 
ATOM   3249 C  CG  . MET A 1 455 ? -16.054 -61.590 -35.788 1.00 46.65  ? 718  MET A CG  1 
ATOM   3250 S  SD  . MET A 1 455 ? -17.535 -60.739 -36.377 1.00 45.41  ? 718  MET A SD  1 
ATOM   3251 C  CE  . MET A 1 455 ? -18.752 -61.949 -35.884 1.00 47.83  ? 718  MET A CE  1 
ATOM   3252 N  N   A LYS A 1 456 ? -14.523 -65.689 -36.640 0.23 44.68  ? 719  LYS A N   1 
ATOM   3253 N  N   B LYS A 1 456 ? -14.514 -65.689 -36.618 0.21 44.57  ? 719  LYS A N   1 
ATOM   3254 C  CA  A LYS A 1 456 ? -14.395 -66.992 -37.344 0.23 48.03  ? 719  LYS A CA  1 
ATOM   3255 C  CA  B LYS A 1 456 ? -14.486 -67.003 -37.316 0.21 47.67  ? 719  LYS A CA  1 
ATOM   3256 C  C   A LYS A 1 456 ? -14.799 -66.820 -38.818 0.23 46.08  ? 719  LYS A C   1 
ATOM   3257 C  C   B LYS A 1 456 ? -14.769 -66.786 -38.809 0.21 45.86  ? 719  LYS A C   1 
ATOM   3258 O  O   A LYS A 1 456 ? -14.259 -67.563 -39.647 0.23 48.13  ? 719  LYS A O   1 
ATOM   3259 O  O   B LYS A 1 456 ? -14.124 -67.456 -39.627 0.21 47.20  ? 719  LYS A O   1 
ATOM   3260 C  CB  A LYS A 1 456 ? -15.184 -68.067 -36.589 0.23 50.64  ? 719  LYS A CB  1 
ATOM   3261 C  CB  B LYS A 1 456 ? -15.486 -67.965 -36.664 0.21 50.04  ? 719  LYS A CB  1 
ATOM   3262 C  CG  A LYS A 1 456 ? -14.425 -68.687 -35.422 0.23 52.43  ? 719  LYS A CG  1 
ATOM   3263 C  CG  B LYS A 1 456 ? -15.586 -69.343 -37.306 0.21 52.32  ? 719  LYS A CG  1 
ATOM   3264 C  CD  A LYS A 1 456 ? -15.252 -69.608 -34.555 0.23 55.48  ? 719  LYS A CD  1 
ATOM   3265 C  CD  B LYS A 1 456 ? -15.811 -70.459 -36.307 0.21 53.39  ? 719  LYS A CD  1 
ATOM   3266 C  CE  A LYS A 1 456 ? -15.733 -68.951 -33.277 0.23 57.87  ? 719  LYS A CE  1 
ATOM   3267 C  CE  B LYS A 1 456 ? -15.857 -71.831 -36.946 0.21 54.48  ? 719  LYS A CE  1 
ATOM   3268 N  NZ  A LYS A 1 456 ? -16.690 -69.817 -32.547 0.23 58.60  ? 719  LYS A NZ  1 
ATOM   3269 N  NZ  B LYS A 1 456 ? -15.518 -72.894 -35.970 0.21 54.92  ? 719  LYS A NZ  1 
ATOM   3270 N  N   . ASP A 1 457 ? -15.659 -65.847 -39.143 1.00 45.20  ? 720  ASP A N   1 
ATOM   3271 C  CA  . ASP A 1 457 ? -16.046 -65.548 -40.562 1.00 47.59  ? 720  ASP A CA  1 
ATOM   3272 C  C   . ASP A 1 457 ? -15.185 -64.467 -41.252 1.00 57.85  ? 720  ASP A C   1 
ATOM   3273 O  O   . ASP A 1 457 ? -15.573 -64.038 -42.359 1.00 58.30  ? 720  ASP A O   1 
ATOM   3274 C  CB  . ASP A 1 457 ? -17.510 -65.125 -40.626 1.00 50.98  ? 720  ASP A CB  1 
ATOM   3275 C  CG  . ASP A 1 457 ? -17.820 -63.864 -39.844 1.00 55.48  ? 720  ASP A CG  1 
ATOM   3276 O  OD1 . ASP A 1 457 ? -16.962 -62.942 -39.846 1.00 48.49  ? 720  ASP A OD1 1 
ATOM   3277 O  OD2 . ASP A 1 457 ? -18.939 -63.790 -39.288 1.00 57.54  ? 720  ASP A OD2 1 
ATOM   3278 N  N   . GLY A 1 458 ? -14.062 -64.034 -40.663 1.00 57.06  ? 721  GLY A N   1 
ATOM   3279 C  CA  . GLY A 1 458 ? -13.100 -63.136 -41.323 1.00 53.63  ? 721  GLY A CA  1 
ATOM   3280 C  C   . GLY A 1 458 ? -13.472 -61.664 -41.193 1.00 56.27  ? 721  GLY A C   1 
ATOM   3281 O  O   . GLY A 1 458 ? -12.644 -60.811 -41.585 1.00 55.07  ? 721  GLY A O   1 
ATOM   3282 N  N   . ARG A 1 459 ? -14.650 -61.328 -40.648 1.00 45.96  ? 722  ARG A N   1 
ATOM   3283 C  CA  . ARG A 1 459 ? -14.979 -59.900 -40.423 1.00 41.13  ? 722  ARG A CA  1 
ATOM   3284 C  C   . ARG A 1 459 ? -14.144 -59.359 -39.238 1.00 41.51  ? 722  ARG A C   1 
ATOM   3285 O  O   . ARG A 1 459 ? -13.861 -60.094 -38.258 1.00 40.66  ? 722  ARG A O   1 
ATOM   3286 C  CB  . ARG A 1 459 ? -16.497 -59.740 -40.237 1.00 47.05  ? 722  ARG A CB  1 
ATOM   3287 C  CG  . ARG A 1 459 ? -17.323 -60.084 -41.471 1.00 45.12  ? 722  ARG A CG  1 
ATOM   3288 C  CD  . ARG A 1 459 ? -18.816 -59.807 -41.295 1.00 43.49  ? 722  ARG A CD  1 
ATOM   3289 N  NE  . ARG A 1 459 ? -19.394 -60.713 -40.325 1.00 39.05  ? 722  ARG A NE  1 
ATOM   3290 C  CZ  . ARG A 1 459 ? -20.678 -60.797 -40.036 1.00 42.59  ? 722  ARG A CZ  1 
ATOM   3291 N  NH1 . ARG A 1 459 ? -21.558 -60.011 -40.633 1.00 45.36  ? 722  ARG A NH1 1 
ATOM   3292 N  NH2 . ARG A 1 459 ? -21.080 -61.672 -39.134 1.00 43.52  ? 722  ARG A NH2 1 
ATOM   3293 N  N   . VAL A 1 460 ? -13.868 -58.065 -39.252 1.00 39.23  ? 723  VAL A N   1 
ATOM   3294 C  CA  . VAL A 1 460 ? -12.910 -57.440 -38.303 1.00 36.53  ? 723  VAL A CA  1 
ATOM   3295 C  C   . VAL A 1 460 ? -13.647 -56.593 -37.284 1.00 34.49  ? 723  VAL A C   1 
ATOM   3296 O  O   . VAL A 1 460 ? -14.307 -55.610 -37.669 1.00 42.77  ? 723  VAL A O   1 
ATOM   3297 C  CB  . VAL A 1 460 ? -11.848 -56.629 -39.058 1.00 39.37  ? 723  VAL A CB  1 
ATOM   3298 C  CG1 . VAL A 1 460 ? -10.868 -55.978 -38.092 1.00 47.35  ? 723  VAL A CG1 1 
ATOM   3299 C  CG2 . VAL A 1 460 ? -11.099 -57.516 -40.038 1.00 40.01  ? 723  VAL A CG2 1 
ATOM   3300 N  N   . LEU A 1 461 ? -13.519 -56.950 -36.007 1.00 32.27  ? 724  LEU A N   1 
ATOM   3301 C  CA  . LEU A 1 461 ? -13.984 -56.098 -34.888 1.00 29.05  ? 724  LEU A CA  1 
ATOM   3302 C  C   . LEU A 1 461 ? -12.778 -55.311 -34.354 1.00 35.18  ? 724  LEU A C   1 
ATOM   3303 O  O   . LEU A 1 461 ? -11.697 -55.917 -34.151 1.00 35.78  ? 724  LEU A O   1 
ATOM   3304 C  CB  . LEU A 1 461 ? -14.565 -57.023 -33.825 1.00 32.29  ? 724  LEU A CB  1 
ATOM   3305 C  CG  . LEU A 1 461 ? -15.751 -57.845 -34.322 1.00 29.20  ? 724  LEU A CG  1 
ATOM   3306 C  CD1 . LEU A 1 461 ? -16.087 -58.885 -33.304 1.00 34.98  ? 724  LEU A CD1 1 
ATOM   3307 C  CD2 . LEU A 1 461 ? -16.912 -56.927 -34.569 1.00 29.09  ? 724  LEU A CD2 1 
ATOM   3308 N  N   . VAL A 1 462 ? -12.945 -54.018 -34.117 1.00 32.13  ? 725  VAL A N   1 
ATOM   3309 C  CA  . VAL A 1 462 ? -11.989 -53.195 -33.323 1.00 30.22  ? 725  VAL A CA  1 
ATOM   3310 C  C   . VAL A 1 462 ? -12.652 -52.869 -31.999 1.00 28.69  ? 725  VAL A C   1 
ATOM   3311 O  O   . VAL A 1 462 ? -13.665 -52.146 -32.005 1.00 30.25  ? 725  VAL A O   1 
ATOM   3312 C  CB  . VAL A 1 462 ? -11.553 -51.925 -34.059 1.00 31.45  ? 725  VAL A CB  1 
ATOM   3313 C  CG1 . VAL A 1 462 ? -10.600 -51.123 -33.176 1.00 32.41  ? 725  VAL A CG1 1 
ATOM   3314 C  CG2 . VAL A 1 462 ? -10.925 -52.263 -35.396 1.00 27.89  ? 725  VAL A CG2 1 
ATOM   3315 N  N   . VAL A 1 463 ? -12.138 -53.452 -30.926 1.00 26.26  ? 726  VAL A N   1 
ATOM   3316 C  CA  . VAL A 1 463 ? -12.855 -53.535 -29.630 1.00 27.61  ? 726  VAL A CA  1 
ATOM   3317 C  C   . VAL A 1 463 ? -12.098 -52.712 -28.603 1.00 28.99  ? 726  VAL A C   1 
ATOM   3318 O  O   . VAL A 1 463 ? -10.862 -52.689 -28.599 1.00 32.82  ? 726  VAL A O   1 
ATOM   3319 C  CB  . VAL A 1 463 ? -12.984 -54.988 -29.166 1.00 29.10  ? 726  VAL A CB  1 
ATOM   3320 C  CG1 . VAL A 1 463 ? -13.887 -55.799 -30.059 1.00 28.75  ? 726  VAL A CG1 1 
ATOM   3321 C  CG2 . VAL A 1 463 ? -11.605 -55.649 -29.024 1.00 29.37  ? 726  VAL A CG2 1 
ATOM   3322 N  N   . PRO A 1 464 ? -12.819 -52.065 -27.680 1.00 27.21  ? 727  PRO A N   1 
ATOM   3323 C  CA  . PRO A 1 464 ? -12.175 -51.300 -26.609 1.00 24.51  ? 727  PRO A CA  1 
ATOM   3324 C  C   . PRO A 1 464 ? -11.770 -52.220 -25.471 1.00 28.85  ? 727  PRO A C   1 
ATOM   3325 O  O   . PRO A 1 464 ? -12.422 -53.230 -25.296 1.00 25.16  ? 727  PRO A O   1 
ATOM   3326 C  CB  . PRO A 1 464 ? -13.320 -50.434 -26.118 1.00 26.01  ? 727  PRO A CB  1 
ATOM   3327 C  CG  . PRO A 1 464 ? -14.549 -51.336 -26.301 1.00 26.12  ? 727  PRO A CG  1 
ATOM   3328 C  CD  . PRO A 1 464 ? -14.291 -52.047 -27.614 1.00 24.88  ? 727  PRO A CD  1 
ATOM   3329 N  N   . CYS A 1 465 ? -10.759 -51.813 -24.701 1.00 27.32  ? 728  CYS A N   1 
ATOM   3330 C  CA  . CYS A 1 465 ? -10.132 -52.646 -23.656 1.00 27.49  ? 728  CYS A CA  1 
ATOM   3331 C  C   . CYS A 1 465 ? -9.456  -51.774 -22.605 1.00 28.53  ? 728  CYS A C   1 
ATOM   3332 O  O   . CYS A 1 465 ? -8.978  -50.700 -22.952 1.00 27.02  ? 728  CYS A O   1 
ATOM   3333 C  CB  . CYS A 1 465 ? -9.134  -53.624 -24.265 1.00 25.14  ? 728  CYS A CB  1 
ATOM   3334 S  SG  . CYS A 1 465 ? -8.722  -54.970 -23.116 1.00 29.45  ? 728  CYS A SG  1 
ATOM   3335 N  N   . ARG A 1 466 ? -9.491  -52.194 -21.347 1.00 29.67  ? 729  ARG A N   1 
ATOM   3336 C  CA  . ARG A 1 466 ? -8.587  -51.650 -20.328 1.00 28.94  ? 729  ARG A CA  1 
ATOM   3337 C  C   . ARG A 1 466 ? -8.312  -52.723 -19.283 1.00 30.08  ? 729  ARG A C   1 
ATOM   3338 O  O   . ARG A 1 466 ? -8.868  -53.826 -19.380 1.00 30.56  ? 729  ARG A O   1 
ATOM   3339 C  CB  . ARG A 1 466 ? -9.155  -50.382 -19.720 1.00 34.31  ? 729  ARG A CB  1 
ATOM   3340 C  CG  . ARG A 1 466 ? -10.473 -50.594 -19.009 1.00 36.97  ? 729  ARG A CG  1 
ATOM   3341 C  CD  . ARG A 1 466 ? -11.179 -49.281 -18.706 1.00 37.10  ? 729  ARG A CD  1 
ATOM   3342 N  NE  . ARG A 1 466 ? -10.583 -48.554 -17.601 1.00 33.97  ? 729  ARG A NE  1 
ATOM   3343 C  CZ  . ARG A 1 466 ? -11.073 -47.428 -17.107 1.00 35.93  ? 729  ARG A CZ  1 
ATOM   3344 N  NH1 . ARG A 1 466 ? -12.184 -46.884 -17.589 1.00 42.80  ? 729  ARG A NH1 1 
ATOM   3345 N  NH2 . ARG A 1 466 ? -10.444 -46.838 -16.131 1.00 37.72  ? 729  ARG A NH2 1 
ATOM   3346 N  N   . ASN A 1 467 ? -7.429  -52.423 -18.336 1.00 30.56  ? 730  ASN A N   1 
ATOM   3347 C  CA  . ASN A 1 467 ? -7.045  -53.398 -17.294 1.00 32.52  ? 730  ASN A CA  1 
ATOM   3348 C  C   . ASN A 1 467 ? -8.335  -53.858 -16.602 1.00 28.79  ? 730  ASN A C   1 
ATOM   3349 O  O   . ASN A 1 467 ? -9.023  -53.035 -16.068 1.00 29.78  ? 730  ASN A O   1 
ATOM   3350 C  CB  . ASN A 1 467 ? -6.042  -52.860 -16.275 1.00 31.12  ? 730  ASN A CB  1 
ATOM   3351 C  CG  . ASN A 1 467 ? -5.790  -53.916 -15.234 1.00 34.32  ? 730  ASN A CG  1 
ATOM   3352 O  OD1 . ASN A 1 467 ? -6.476  -53.944 -14.239 1.00 35.12  ? 730  ASN A OD1 1 
ATOM   3353 N  ND2 . ASN A 1 467 ? -4.866  -54.837 -15.494 1.00 41.81  ? 730  ASN A ND2 1 
ATOM   3354 N  N   . GLN A 1 468 ? -8.510  -55.165 -16.476 1.00 28.31  ? 731  GLN A N   1 
ATOM   3355 C  CA  . GLN A 1 468 ? -9.783  -55.777 -16.051 1.00 31.05  ? 731  GLN A CA  1 
ATOM   3356 C  C   . GLN A 1 468 ? -10.004 -55.489 -14.569 1.00 29.79  ? 731  GLN A C   1 
ATOM   3357 O  O   . GLN A 1 468 ? -11.153 -55.405 -14.182 1.00 28.31  ? 731  GLN A O   1 
ATOM   3358 C  CB  . GLN A 1 468 ? -9.822  -57.265 -16.380 1.00 30.03  ? 731  GLN A CB  1 
ATOM   3359 C  CG  . GLN A 1 468 ? -11.195 -57.898 -16.138 1.00 29.00  ? 731  GLN A CG  1 
ATOM   3360 C  CD  . GLN A 1 468 ? -11.116 -59.383 -16.322 1.00 28.73  ? 731  GLN A CD  1 
ATOM   3361 O  OE1 . GLN A 1 468 ? -11.397 -59.866 -17.407 1.00 27.56  ? 731  GLN A OE1 1 
ATOM   3362 N  NE2 . GLN A 1 468 ? -10.680 -60.100 -15.291 1.00 29.59  ? 731  GLN A NE2 1 
ATOM   3363 N  N   . ASP A 1 469 ? -8.954  -55.289 -13.791 1.00 30.11  ? 732  ASP A N   1 
ATOM   3364 C  CA  . ASP A 1 469 ? -9.124  -54.912 -12.364 1.00 31.72  ? 732  ASP A CA  1 
ATOM   3365 C  C   . ASP A 1 469 ? -9.883  -53.591 -12.281 1.00 31.14  ? 732  ASP A C   1 
ATOM   3366 O  O   . ASP A 1 469 ? -10.618 -53.398 -11.305 1.00 31.65  ? 732  ASP A O   1 
ATOM   3367 C  CB  . ASP A 1 469 ? -7.800  -54.769 -11.607 1.00 32.72  ? 732  ASP A CB  1 
ATOM   3368 C  CG  . ASP A 1 469 ? -7.037  -56.076 -11.453 1.00 35.34  ? 732  ASP A CG  1 
ATOM   3369 O  OD1 . ASP A 1 469 ? -7.639  -57.190 -11.652 1.00 32.94  ? 732  ASP A OD1 1 
ATOM   3370 O  OD2 . ASP A 1 469 ? -5.842  -55.975 -11.180 1.00 39.54  ? 732  ASP A OD2 1 
ATOM   3371 N  N   . GLU A 1 470 ? -9.621  -52.675 -13.203 1.00 29.24  ? 733  GLU A N   1 
ATOM   3372 C  CA  . GLU A 1 470 ? -10.285 -51.350 -13.231 1.00 31.36  ? 733  GLU A CA  1 
ATOM   3373 C  C   . GLU A 1 470 ? -11.790 -51.554 -13.544 1.00 29.56  ? 733  GLU A C   1 
ATOM   3374 O  O   . GLU A 1 470 ? -12.613 -50.895 -12.923 1.00 30.04  ? 733  GLU A O   1 
ATOM   3375 C  CB  . GLU A 1 470 ? -9.674  -50.449 -14.314 1.00 32.88  ? 733  GLU A CB  1 
ATOM   3376 C  CG  . GLU A 1 470 ? -8.189  -50.140 -14.125 1.00 38.94  ? 733  GLU A CG  1 
ATOM   3377 C  CD  . GLU A 1 470 ? -7.535  -49.282 -15.205 1.00 43.02  ? 733  GLU A CD  1 
ATOM   3378 O  OE1 . GLU A 1 470 ? -6.322  -49.059 -15.095 1.00 55.04  ? 733  GLU A OE1 1 
ATOM   3379 O  OE2 . GLU A 1 470 ? -8.228  -48.816 -16.147 1.00 42.08  ? 733  GLU A OE2 1 
ATOM   3380 N  N   . LEU A 1 471 ? -12.134 -52.390 -14.516 1.00 25.96  ? 734  LEU A N   1 
ATOM   3381 C  CA  . LEU A 1 471 ? -13.541 -52.675 -14.874 1.00 26.54  ? 734  LEU A CA  1 
ATOM   3382 C  C   . LEU A 1 471 ? -14.291 -53.299 -13.695 1.00 27.67  ? 734  LEU A C   1 
ATOM   3383 O  O   . LEU A 1 471 ? -15.375 -52.773 -13.307 1.00 26.71  ? 734  LEU A O   1 
ATOM   3384 C  CB  . LEU A 1 471 ? -13.541 -53.558 -16.117 1.00 26.49  ? 734  LEU A CB  1 
ATOM   3385 C  CG  . LEU A 1 471 ? -13.002 -52.818 -17.336 1.00 28.49  ? 734  LEU A CG  1 
ATOM   3386 C  CD1 . LEU A 1 471 ? -12.952 -53.712 -18.550 1.00 27.86  ? 734  LEU A CD1 1 
ATOM   3387 C  CD2 . LEU A 1 471 ? -13.850 -51.594 -17.607 1.00 31.62  ? 734  LEU A CD2 1 
ATOM   3388 N  N   . ILE A 1 472 ? -13.705 -54.300 -13.062 1.00 29.09  ? 735  ILE A N   1 
ATOM   3389 C  CA  . ILE A 1 472 ? -14.381 -55.031 -11.959 1.00 27.45  ? 735  ILE A CA  1 
ATOM   3390 C  C   . ILE A 1 472 ? -14.488 -54.127 -10.741 1.00 27.52  ? 735  ILE A C   1 
ATOM   3391 O  O   . ILE A 1 472 ? -15.580 -54.104 -10.085 1.00 27.48  ? 735  ILE A O   1 
ATOM   3392 C  CB  . ILE A 1 472 ? -13.692 -56.363 -11.701 1.00 27.13  ? 735  ILE A CB  1 
ATOM   3393 C  CG1 . ILE A 1 472 ? -13.985 -57.243 -12.915 1.00 30.25  ? 735  ILE A CG1 1 
ATOM   3394 C  CG2 . ILE A 1 472 ? -14.175 -56.986 -10.390 1.00 28.41  ? 735  ILE A CG2 1 
ATOM   3395 C  CD1 . ILE A 1 472 ? -13.265 -58.541 -12.938 1.00 33.24  ? 735  ILE A CD1 1 
ATOM   3396 N  N   . GLY A 1 473 ? -13.456 -53.337 -10.490 1.00 26.56  ? 736  GLY A N   1 
ATOM   3397 C  CA  . GLY A 1 473 ? -13.431 -52.423 -9.328  1.00 29.27  ? 736  GLY A CA  1 
ATOM   3398 C  C   . GLY A 1 473 ? -14.498 -51.318 -9.405  1.00 30.06  ? 736  GLY A C   1 
ATOM   3399 O  O   . GLY A 1 473 ? -15.107 -50.991 -8.365  1.00 32.37  ? 736  GLY A O   1 
ATOM   3400 N  N   . ARG A 1 474 ? -14.718 -50.762 -10.601 0.44 29.80  ? 737  ARG A N   1 
ATOM   3401 C  CA  . ARG A 1 474 ? -15.728 -49.700 -10.858 0.44 32.29  ? 737  ARG A CA  1 
ATOM   3402 C  C   . ARG A 1 474 ? -17.136 -50.293 -10.694 0.44 31.07  ? 737  ARG A C   1 
ATOM   3403 O  O   . ARG A 1 474 ? -17.965 -49.656 -10.022 0.44 31.21  ? 737  ARG A O   1 
ATOM   3404 C  CB  . ARG A 1 474 ? -15.552 -49.101 -12.259 0.44 35.92  ? 737  ARG A CB  1 
ATOM   3405 C  CG  . ARG A 1 474 ? -14.179 -48.492 -12.504 0.44 43.25  ? 737  ARG A CG  1 
ATOM   3406 C  CD  . ARG A 1 474 ? -13.924 -48.053 -13.940 0.44 46.51  ? 737  ARG A CD  1 
ATOM   3407 N  NE  . ARG A 1 474 ? -14.312 -46.659 -14.090 0.44 50.94  ? 737  ARG A NE  1 
ATOM   3408 C  CZ  . ARG A 1 474 ? -13.643 -45.624 -13.582 0.44 53.54  ? 737  ARG A CZ  1 
ATOM   3409 N  NH1 . ARG A 1 474 ? -14.103 -44.396 -13.758 0.44 54.58  ? 737  ARG A NH1 1 
ATOM   3410 N  NH2 . ARG A 1 474 ? -12.522 -45.815 -12.902 0.44 54.37  ? 737  ARG A NH2 1 
ATOM   3411 N  N   . ALA A 1 475 ? -17.382 -51.482 -11.254 1.00 29.47  ? 738  ALA A N   1 
ATOM   3412 C  CA  . ALA A 1 475 ? -18.711 -52.140 -11.209 1.00 30.85  ? 738  ALA A CA  1 
ATOM   3413 C  C   . ALA A 1 475 ? -19.062 -52.504 -9.757  1.00 32.26  ? 738  ALA A C   1 
ATOM   3414 O  O   . ALA A 1 475 ? -20.256 -52.638 -9.445  1.00 30.83  ? 738  ALA A O   1 
ATOM   3415 C  CB  . ALA A 1 475 ? -18.745 -53.337 -12.125 1.00 29.58  ? 738  ALA A CB  1 
ATOM   3416 N  N   . ARG A 1 476 ? -18.078 -52.586 -8.861  1.00 32.56  ? 739  ARG A N   1 
ATOM   3417 C  CA  . ARG A 1 476 ? -18.343 -52.970 -7.441  1.00 33.15  ? 739  ARG A CA  1 
ATOM   3418 C  C   . ARG A 1 476 ? -18.715 -51.727 -6.639  1.00 33.33  ? 739  ARG A C   1 
ATOM   3419 O  O   . ARG A 1 476 ? -19.023 -51.835 -5.445  1.00 30.43  ? 739  ARG A O   1 
ATOM   3420 C  CB  . ARG A 1 476 ? -17.178 -53.792 -6.882  1.00 30.30  ? 739  ARG A CB  1 
ATOM   3421 C  CG  . ARG A 1 476 ? -17.207 -55.220 -7.402  1.00 30.46  ? 739  ARG A CG  1 
ATOM   3422 C  CD  . ARG A 1 476 ? -15.883 -55.984 -7.298  1.00 33.31  ? 739  ARG A CD  1 
ATOM   3423 N  NE  . ARG A 1 476 ? -15.416 -56.180 -5.942  1.00 28.49  ? 739  ARG A NE  1 
ATOM   3424 C  CZ  . ARG A 1 476 ? -15.151 -57.350 -5.373  1.00 28.98  ? 739  ARG A CZ  1 
ATOM   3425 N  NH1 . ARG A 1 476 ? -15.322 -58.467 -6.032  1.00 30.78  ? 739  ARG A NH1 1 
ATOM   3426 N  NH2 . ARG A 1 476 ? -14.675 -57.396 -4.134  1.00 31.45  ? 739  ARG A NH2 1 
ATOM   3427 N  N   . ILE A 1 477 ? -18.731 -50.574 -7.270  1.00 33.93  ? 740  ILE A N   1 
ATOM   3428 C  CA  . ILE A 1 477 ? -18.998 -49.328 -6.513  1.00 47.22  ? 740  ILE A CA  1 
ATOM   3429 C  C   . ILE A 1 477 ? -20.347 -48.748 -6.951  1.00 50.43  ? 740  ILE A C   1 
ATOM   3430 O  O   . ILE A 1 477 ? -20.593 -48.654 -8.157  1.00 45.21  ? 740  ILE A O   1 
ATOM   3431 C  CB  . ILE A 1 477 ? -17.845 -48.337 -6.704  1.00 43.54  ? 740  ILE A CB  1 
ATOM   3432 C  CG1 . ILE A 1 477 ? -16.579 -48.829 -5.991  1.00 44.82  ? 740  ILE A CG1 1 
ATOM   3433 C  CG2 . ILE A 1 477 ? -18.258 -46.960 -6.231  1.00 44.96  ? 740  ILE A CG2 1 
ATOM   3434 C  CD1 . ILE A 1 477 ? -15.322 -48.064 -6.386  1.00 41.99  ? 740  ILE A CD1 1 
ATOM   3435 N  N   A SER A 1 478 ? -21.180 -48.393 -5.968  0.23 53.62  ? 741  SER A N   1 
ATOM   3436 N  N   B SER A 1 478 ? -21.203 -48.401 -5.982  0.21 52.35  ? 741  SER A N   1 
ATOM   3437 C  CA  A SER A 1 478 ? -22.421 -47.587 -6.120  0.23 62.10  ? 741  SER A CA  1 
ATOM   3438 C  CA  B SER A 1 478 ? -22.443 -47.598 -6.182  0.21 59.48  ? 741  SER A CA  1 
ATOM   3439 C  C   A SER A 1 478 ? -22.153 -46.168 -5.602  0.23 67.30  ? 741  SER A C   1 
ATOM   3440 C  C   B SER A 1 478 ? -22.246 -46.199 -5.578  0.21 65.53  ? 741  SER A C   1 
ATOM   3441 O  O   A SER A 1 478 ? -21.456 -46.034 -4.572  0.23 69.96  ? 741  SER A O   1 
ATOM   3442 O  O   B SER A 1 478 ? -21.695 -46.106 -4.459  0.21 68.77  ? 741  SER A O   1 
ATOM   3443 C  CB  A SER A 1 478 ? -23.584 -48.240 -5.402  0.23 62.48  ? 741  SER A CB  1 
ATOM   3444 C  CB  B SER A 1 478 ? -23.683 -48.288 -5.631  0.21 58.31  ? 741  SER A CB  1 
ATOM   3445 O  OG  A SER A 1 478 ? -24.704 -47.368 -5.325  0.23 61.48  ? 741  SER A OG  1 
ATOM   3446 O  OG  B SER A 1 478 ? -23.366 -49.304 -4.687  0.21 53.96  ? 741  SER A OG  1 
ATOM   3447 N  N   . GLN A 1 479 ? -22.656 -45.153 -6.311  0.44 75.90  ? 742  GLN A N   1 
ATOM   3448 C  CA  . GLN A 1 479 ? -22.541 -43.721 -5.918  0.44 81.60  ? 742  GLN A CA  1 
ATOM   3449 C  C   . GLN A 1 479 ? -23.855 -43.268 -5.274  0.44 79.97  ? 742  GLN A C   1 
ATOM   3450 O  O   . GLN A 1 479 ? -24.920 -43.473 -5.890  0.44 76.59  ? 742  GLN A O   1 
ATOM   3451 C  CB  . GLN A 1 479 ? -22.190 -42.845 -7.122  0.44 85.94  ? 742  GLN A CB  1 
ATOM   3452 C  CG  . GLN A 1 479 ? -20.797 -43.102 -7.687  0.44 92.43  ? 742  GLN A CG  1 
ATOM   3453 C  CD  . GLN A 1 479 ? -19.694 -42.999 -6.657  0.44 95.77  ? 742  GLN A CD  1 
ATOM   3454 O  OE1 . GLN A 1 479 ? -19.825 -42.333 -5.631  0.44 96.65  ? 742  GLN A OE1 1 
ATOM   3455 N  NE2 . GLN A 1 479 ? -18.581 -43.661 -6.932  0.44 96.63  ? 742  GLN A NE2 1 
ATOM   3456 N  N   . GLY A 1 480 ? -23.765 -42.666 -4.084  0.44 80.61  ? 743  GLY A N   1 
ATOM   3457 C  CA  . GLY A 1 480 ? -24.924 -42.293 -3.252  0.44 80.05  ? 743  GLY A CA  1 
ATOM   3458 C  C   . GLY A 1 480 ? -25.541 -43.516 -2.595  0.44 77.63  ? 743  GLY A C   1 
ATOM   3459 O  O   . GLY A 1 480 ? -25.387 -44.630 -3.141  0.44 75.50  ? 743  GLY A O   1 
ATOM   3460 N  N   . ALA A 1 481 ? -26.215 -43.313 -1.462  0.44 76.41  ? 744  ALA A N   1 
ATOM   3461 C  CA  . ALA A 1 481 ? -26.845 -44.373 -0.642  0.44 75.91  ? 744  ALA A CA  1 
ATOM   3462 C  C   . ALA A 1 481 ? -28.356 -44.117 -0.528  0.44 74.48  ? 744  ALA A C   1 
ATOM   3463 O  O   . ALA A 1 481 ? -28.849 -43.135 -1.122  0.44 68.15  ? 744  ALA A O   1 
ATOM   3464 C  CB  . ALA A 1 481 ? -26.173 -44.429 0.706   0.44 76.41  ? 744  ALA A CB  1 
ATOM   3465 N  N   . GLY A 1 482 ? -29.052 -44.987 0.210   1.00 71.32  ? 745  GLY A N   1 
ATOM   3466 C  CA  . GLY A 1 482 ? -30.523 -45.090 0.205   1.00 67.75  ? 745  GLY A CA  1 
ATOM   3467 C  C   . GLY A 1 482 ? -30.979 -46.054 -0.867  1.00 58.84  ? 745  GLY A C   1 
ATOM   3468 O  O   . GLY A 1 482 ? -32.170 -46.099 -1.117  1.00 63.72  ? 745  GLY A O   1 
ATOM   3469 N  N   . TRP A 1 483 ? -30.062 -46.801 -1.491  1.00 49.55  ? 746  TRP A N   1 
ATOM   3470 C  CA  . TRP A 1 483 ? -30.399 -47.721 -2.603  1.00 46.87  ? 746  TRP A CA  1 
ATOM   3471 C  C   . TRP A 1 483 ? -31.108 -48.955 -2.039  1.00 41.07  ? 746  TRP A C   1 
ATOM   3472 O  O   . TRP A 1 483 ? -30.624 -49.580 -1.116  1.00 43.12  ? 746  TRP A O   1 
ATOM   3473 C  CB  . TRP A 1 483 ? -29.159 -48.072 -3.431  1.00 56.35  ? 746  TRP A CB  1 
ATOM   3474 C  CG  . TRP A 1 483 ? -28.649 -46.929 -4.252  1.00 66.53  ? 746  TRP A CG  1 
ATOM   3475 C  CD1 . TRP A 1 483 ? -28.415 -45.649 -3.832  1.00 85.67  ? 746  TRP A CD1 1 
ATOM   3476 C  CD2 . TRP A 1 483 ? -28.294 -46.954 -5.641  1.00 68.34  ? 746  TRP A CD2 1 
ATOM   3477 N  NE1 . TRP A 1 483 ? -27.956 -44.873 -4.862  1.00 88.10  ? 746  TRP A NE1 1 
ATOM   3478 C  CE2 . TRP A 1 483 ? -27.870 -45.649 -5.985  1.00 83.25  ? 746  TRP A CE2 1 
ATOM   3479 C  CE3 . TRP A 1 483 ? -28.329 -47.936 -6.633  1.00 63.16  ? 746  TRP A CE3 1 
ATOM   3480 C  CZ2 . TRP A 1 483 ? -27.463 -45.316 -7.274  1.00 78.63  ? 746  TRP A CZ2 1 
ATOM   3481 C  CZ3 . TRP A 1 483 ? -27.926 -47.607 -7.906  1.00 66.83  ? 746  TRP A CZ3 1 
ATOM   3482 C  CH2 . TRP A 1 483 ? -27.500 -46.315 -8.218  1.00 76.24  ? 746  TRP A CH2 1 
ATOM   3483 N  N   . SER A 1 484 ? -32.258 -49.287 -2.585  1.00 39.25  ? 747  SER A N   1 
ATOM   3484 C  CA  . SER A 1 484 ? -32.943 -50.568 -2.300  1.00 39.01  ? 747  SER A CA  1 
ATOM   3485 C  C   . SER A 1 484 ? -32.117 -51.705 -2.915  1.00 33.03  ? 747  SER A C   1 
ATOM   3486 O  O   . SER A 1 484 ? -31.270 -51.408 -3.746  1.00 31.40  ? 747  SER A O   1 
ATOM   3487 C  CB  . SER A 1 484 ? -34.345 -50.535 -2.853  1.00 38.12  ? 747  SER A CB  1 
ATOM   3488 O  OG  . SER A 1 484 ? -34.269 -50.393 -4.255  1.00 34.42  ? 747  SER A OG  1 
ATOM   3489 N  N   . LEU A 1 485 ? -32.444 -52.957 -2.590  1.00 32.23  ? 748  LEU A N   1 
ATOM   3490 C  CA  . LEU A 1 485 ? -31.854 -54.161 -3.208  1.00 37.41  ? 748  LEU A CA  1 
ATOM   3491 C  C   . LEU A 1 485 ? -32.110 -54.159 -4.712  1.00 41.16  ? 748  LEU A C   1 
ATOM   3492 O  O   . LEU A 1 485 ? -31.167 -54.454 -5.509  1.00 36.34  ? 748  LEU A O   1 
ATOM   3493 C  CB  . LEU A 1 485 ? -32.436 -55.418 -2.573  1.00 38.11  ? 748  LEU A CB  1 
ATOM   3494 C  CG  . LEU A 1 485 ? -31.802 -56.713 -3.076  1.00 41.73  ? 748  LEU A CG  1 
ATOM   3495 C  CD1 . LEU A 1 485 ? -30.290 -56.551 -3.168  1.00 42.88  ? 748  LEU A CD1 1 
ATOM   3496 C  CD2 . LEU A 1 485 ? -32.138 -57.876 -2.168  1.00 39.80  ? 748  LEU A CD2 1 
ATOM   3497 N  N   . ARG A 1 486 ? -33.350 -53.865 -5.076  1.00 36.95  ? 749  ARG A N   1 
ATOM   3498 C  CA  . ARG A 1 486 ? -33.789 -53.837 -6.486  1.00 37.78  ? 749  ARG A CA  1 
ATOM   3499 C  C   . ARG A 1 486 ? -32.923 -52.834 -7.258  1.00 30.27  ? 749  ARG A C   1 
ATOM   3500 O  O   . ARG A 1 486 ? -32.508 -53.146 -8.353  1.00 30.81  ? 749  ARG A O   1 
ATOM   3501 C  CB  . ARG A 1 486 ? -35.280 -53.471 -6.573  1.00 39.65  ? 749  ARG A CB  1 
ATOM   3502 C  CG  . ARG A 1 486 ? -35.808 -53.512 -7.998  1.00 40.38  ? 749  ARG A CG  1 
ATOM   3503 C  CD  . ARG A 1 486 ? -37.251 -53.063 -8.070  1.00 46.42  ? 749  ARG A CD  1 
ATOM   3504 N  NE  . ARG A 1 486 ? -37.767 -53.109 -9.435  1.00 44.88  ? 749  ARG A NE  1 
ATOM   3505 C  CZ  . ARG A 1 486 ? -38.839 -53.801 -9.808  1.00 45.97  ? 749  ARG A CZ  1 
ATOM   3506 N  NH1 . ARG A 1 486 ? -39.509 -54.510 -8.917  1.00 41.92  ? 749  ARG A NH1 1 
ATOM   3507 N  NH2 . ARG A 1 486 ? -39.230 -53.785 -11.069 1.00 43.55  ? 749  ARG A NH2 1 
ATOM   3508 N  N   . GLU A 1 487 ? -32.753 -51.624 -6.757  1.00 28.80  ? 750  GLU A N   1 
ATOM   3509 C  CA  . GLU A 1 487 ? -31.970 -50.575 -7.465  1.00 35.02  ? 750  GLU A CA  1 
ATOM   3510 C  C   . GLU A 1 487 ? -30.485 -51.006 -7.572  1.00 36.19  ? 750  GLU A C   1 
ATOM   3511 O  O   . GLU A 1 487 ? -29.870 -50.810 -8.649  1.00 31.34  ? 750  GLU A O   1 
ATOM   3512 C  CB  . GLU A 1 487 ? -32.068 -49.210 -6.771  1.00 43.41  ? 750  GLU A CB  1 
ATOM   3513 C  CG  . GLU A 1 487 ? -32.213 -48.087 -7.795  1.00 64.58  ? 750  GLU A CG  1 
ATOM   3514 C  CD  . GLU A 1 487 ? -31.825 -46.660 -7.412  1.00 80.01  ? 750  GLU A CD  1 
ATOM   3515 O  OE1 . GLU A 1 487 ? -31.729 -46.385 -6.182  1.00 88.31  ? 750  GLU A OE1 1 
ATOM   3516 O  OE2 . GLU A 1 487 ? -31.632 -45.805 -8.363  1.00 68.10  ? 750  GLU A OE2 1 
ATOM   3517 N  N   . THR A 1 488 ? -29.932 -51.584 -6.510  1.00 31.71  ? 751  THR A N   1 
ATOM   3518 C  CA  . THR A 1 488 ? -28.538 -52.109 -6.496  1.00 30.80  ? 751  THR A CA  1 
ATOM   3519 C  C   . THR A 1 488 ? -28.445 -53.184 -7.583  1.00 35.15  ? 751  THR A C   1 
ATOM   3520 O  O   . THR A 1 488 ? -27.446 -53.140 -8.381  1.00 35.40  ? 751  THR A O   1 
ATOM   3521 C  CB  . THR A 1 488 ? -28.187 -52.657 -5.124  1.00 29.85  ? 751  THR A CB  1 
ATOM   3522 O  OG1 . THR A 1 488 ? -28.393 -51.541 -4.240  1.00 32.24  ? 751  THR A OG1 1 
ATOM   3523 C  CG2 . THR A 1 488 ? -26.787 -53.233 -5.096  1.00 31.59  ? 751  THR A CG2 1 
ATOM   3524 N  N   . ALA A 1 489 ? -29.480 -54.030 -7.713  1.00 31.47  ? 752  ALA A N   1 
ATOM   3525 C  CA  . ALA A 1 489 ? -29.477 -55.144 -8.689  1.00 28.84  ? 752  ALA A CA  1 
ATOM   3526 C  C   . ALA A 1 489 ? -29.502 -54.574 -10.106 1.00 33.24  ? 752  ALA A C   1 
ATOM   3527 O  O   . ALA A 1 489 ? -28.798 -55.126 -10.968 1.00 30.58  ? 752  ALA A O   1 
ATOM   3528 C  CB  . ALA A 1 489 ? -30.632 -56.054 -8.430  1.00 28.85  ? 752  ALA A CB  1 
ATOM   3529 N  N   . CYS A 1 490 ? -30.300 -53.515 -10.334 1.00 32.24  ? 753  CYS A N   1 
ATOM   3530 C  CA  . CYS A 1 490 ? -30.497 -52.879 -11.663 1.00 30.33  ? 753  CYS A CA  1 
ATOM   3531 C  C   . CYS A 1 490 ? -29.213 -52.129 -12.066 1.00 28.58  ? 753  CYS A C   1 
ATOM   3532 O  O   . CYS A 1 490 ? -28.872 -52.117 -13.250 1.00 27.15  ? 753  CYS A O   1 
ATOM   3533 C  CB  . CYS A 1 490 ? -31.726 -51.971 -11.667 1.00 32.46  ? 753  CYS A CB  1 
ATOM   3534 S  SG  . CYS A 1 490 ? -33.290 -52.919 -11.543 1.00 36.37  ? 753  CYS A SG  1 
ATOM   3535 N  N   . LEU A 1 491 ? -28.483 -51.548 -11.130 1.00 28.24  ? 754  LEU A N   1 
ATOM   3536 C  CA  . LEU A 1 491 ? -27.129 -50.984 -11.436 1.00 29.40  ? 754  LEU A CA  1 
ATOM   3537 C  C   . LEU A 1 491 ? -26.132 -52.089 -11.834 1.00 31.09  ? 754  LEU A C   1 
ATOM   3538 O  O   . LEU A 1 491 ? -25.390 -51.909 -12.803 1.00 34.95  ? 754  LEU A O   1 
ATOM   3539 C  CB  . LEU A 1 491 ? -26.638 -50.189 -10.228 1.00 30.46  ? 754  LEU A CB  1 
ATOM   3540 C  CG  . LEU A 1 491 ? -25.289 -49.491 -10.431 1.00 34.22  ? 754  LEU A CG  1 
ATOM   3541 C  CD1 . LEU A 1 491 ? -25.321 -48.543 -11.601 1.00 32.93  ? 754  LEU A CD1 1 
ATOM   3542 C  CD2 . LEU A 1 491 ? -24.820 -48.759 -9.175  1.00 35.28  ? 754  LEU A CD2 1 
ATOM   3543 N  N   . GLY A 1 492 ? -26.134 -53.216 -11.125 1.00 32.21  ? 755  GLY A N   1 
ATOM   3544 C  CA  . GLY A 1 492 ? -25.296 -54.367 -11.454 1.00 29.05  ? 755  GLY A CA  1 
ATOM   3545 C  C   . GLY A 1 492 ? -25.568 -54.842 -12.860 1.00 31.54  ? 755  GLY A C   1 
ATOM   3546 O  O   . GLY A 1 492 ? -24.620 -55.134 -13.620 1.00 30.97  ? 755  GLY A O   1 
ATOM   3547 N  N   . LYS A 1 493 ? -26.843 -54.880 -13.243 1.00 29.36  ? 756  LYS A N   1 
ATOM   3548 C  CA  . LYS A 1 493 ? -27.255 -55.327 -14.597 1.00 28.23  ? 756  LYS A CA  1 
ATOM   3549 C  C   . LYS A 1 493 ? -26.772 -54.333 -15.660 1.00 25.06  ? 756  LYS A C   1 
ATOM   3550 O  O   . LYS A 1 493 ? -26.405 -54.779 -16.741 1.00 31.42  ? 756  LYS A O   1 
ATOM   3551 C  CB  . LYS A 1 493 ? -28.777 -55.486 -14.640 1.00 32.18  ? 756  LYS A CB  1 
ATOM   3552 C  CG  . LYS A 1 493 ? -29.361 -56.022 -15.938 1.00 32.86  ? 756  LYS A CG  1 
ATOM   3553 C  CD  . LYS A 1 493 ? -30.839 -56.320 -15.824 1.00 35.13  ? 756  LYS A CD  1 
ATOM   3554 C  CE  . LYS A 1 493 ? -31.432 -56.885 -17.094 1.00 39.36  ? 756  LYS A CE  1 
ATOM   3555 N  NZ  . LYS A 1 493 ? -32.796 -57.417 -16.875 1.00 43.21  ? 756  LYS A NZ  1 
ATOM   3556 N  N   . SER A 1 494 ? -26.782 -53.043 -15.347 1.00 26.58  ? 757  SER A N   1 
ATOM   3557 C  CA  . SER A 1 494 ? -26.265 -52.015 -16.284 1.00 33.31  ? 757  SER A CA  1 
ATOM   3558 C  C   . SER A 1 494 ? -24.798 -52.307 -16.620 1.00 31.99  ? 757  SER A C   1 
ATOM   3559 O  O   . SER A 1 494 ? -24.449 -52.270 -17.796 1.00 27.63  ? 757  SER A O   1 
ATOM   3560 C  CB  . SER A 1 494 ? -26.411 -50.644 -15.704 1.00 33.52  ? 757  SER A CB  1 
ATOM   3561 O  OG  . SER A 1 494 ? -27.747 -50.392 -15.309 1.00 52.47  ? 757  SER A OG  1 
ATOM   3562 N  N   . TYR A 1 495 ? -23.989 -52.593 -15.604 1.00 26.72  ? 758  TYR A N   1 
ATOM   3563 C  CA  . TYR A 1 495 ? -22.555 -52.908 -15.822 1.00 31.37  ? 758  TYR A CA  1 
ATOM   3564 C  C   . TYR A 1 495 ? -22.426 -54.196 -16.639 1.00 29.42  ? 758  TYR A C   1 
ATOM   3565 O  O   . TYR A 1 495 ? -21.654 -54.222 -17.594 1.00 29.35  ? 758  TYR A O   1 
ATOM   3566 C  CB  . TYR A 1 495 ? -21.834 -52.977 -14.476 1.00 29.08  ? 758  TYR A CB  1 
ATOM   3567 C  CG  . TYR A 1 495 ? -21.353 -51.646 -13.961 1.00 30.84  ? 758  TYR A CG  1 
ATOM   3568 C  CD1 . TYR A 1 495 ? -20.254 -51.024 -14.526 1.00 31.69  ? 758  TYR A CD1 1 
ATOM   3569 C  CD2 . TYR A 1 495 ? -21.992 -51.008 -12.914 1.00 33.04  ? 758  TYR A CD2 1 
ATOM   3570 C  CE1 . TYR A 1 495 ? -19.804 -49.800 -14.068 1.00 28.89  ? 758  TYR A CE1 1 
ATOM   3571 C  CE2 . TYR A 1 495 ? -21.554 -49.783 -12.442 1.00 34.05  ? 758  TYR A CE2 1 
ATOM   3572 C  CZ  . TYR A 1 495 ? -20.456 -49.177 -13.021 1.00 37.92  ? 758  TYR A CZ  1 
ATOM   3573 O  OH  . TYR A 1 495 ? -20.012 -47.972 -12.567 1.00 37.43  ? 758  TYR A OH  1 
ATOM   3574 N  N   . ALA A 1 496 ? -23.204 -55.210 -16.281 1.00 29.71  ? 759  ALA A N   1 
ATOM   3575 C  CA  . ALA A 1 496 ? -23.140 -56.510 -16.975 1.00 26.38  ? 759  ALA A CA  1 
ATOM   3576 C  C   . ALA A 1 496 ? -23.477 -56.345 -18.459 1.00 28.86  ? 759  ALA A C   1 
ATOM   3577 O  O   . ALA A 1 496 ? -22.795 -56.951 -19.280 1.00 30.10  ? 759  ALA A O   1 
ATOM   3578 C  CB  . ALA A 1 496 ? -24.075 -57.463 -16.300 1.00 27.88  ? 759  ALA A CB  1 
ATOM   3579 N  N   . GLN A 1 497 ? -24.501 -55.552 -18.769 0.38 28.77  ? 760  GLN A N   1 
ATOM   3580 C  CA  . GLN A 1 497 ? -24.921 -55.356 -20.182 0.38 28.74  ? 760  GLN A CA  1 
ATOM   3581 C  C   . GLN A 1 497 ? -23.843 -54.552 -20.917 0.38 27.65  ? 760  GLN A C   1 
ATOM   3582 O  O   . GLN A 1 497 ? -23.585 -54.854 -22.092 0.38 27.46  ? 760  GLN A O   1 
ATOM   3583 C  CB  . GLN A 1 497 ? -26.316 -54.729 -20.228 0.38 29.78  ? 760  GLN A CB  1 
ATOM   3584 C  CG  . GLN A 1 497 ? -27.391 -55.657 -19.676 0.38 30.18  ? 760  GLN A CG  1 
ATOM   3585 C  CD  . GLN A 1 497 ? -28.792 -55.286 -20.094 0.38 29.76  ? 760  GLN A CD  1 
ATOM   3586 O  OE1 . GLN A 1 497 ? -29.680 -56.131 -20.166 0.38 29.04  ? 760  GLN A OE1 1 
ATOM   3587 N  NE2 . GLN A 1 497 ? -29.003 -54.013 -20.379 0.38 30.55  ? 760  GLN A NE2 1 
ATOM   3588 N  N   . MET A 1 498 ? -23.230 -53.581 -20.239 1.00 26.91  ? 761  MET A N   1 
ATOM   3589 C  CA  . MET A 1 498 ? -22.116 -52.814 -20.850 1.00 28.78  ? 761  MET A CA  1 
ATOM   3590 C  C   . MET A 1 498 ? -20.973 -53.777 -21.181 1.00 25.84  ? 761  MET A C   1 
ATOM   3591 O  O   . MET A 1 498 ? -20.443 -53.697 -22.286 1.00 26.08  ? 761  MET A O   1 
ATOM   3592 C  CB  . MET A 1 498 ? -21.593 -51.733 -19.907 1.00 35.73  ? 761  MET A CB  1 
ATOM   3593 C  CG  . MET A 1 498 ? -20.405 -50.989 -20.482 1.00 42.92  ? 761  MET A CG  1 
ATOM   3594 S  SD  . MET A 1 498 ? -19.686 -49.783 -19.351 1.00 48.72  ? 761  MET A SD  1 
ATOM   3595 C  CE  . MET A 1 498 ? -19.045 -50.867 -18.078 1.00 49.86  ? 761  MET A CE  1 
ATOM   3596 N  N   . TRP A 1 499 ? -20.651 -54.668 -20.253 1.00 23.25  ? 762  TRP A N   1 
ATOM   3597 C  CA  . TRP A 1 499 ? -19.562 -55.652 -20.452 1.00 24.38  ? 762  TRP A CA  1 
ATOM   3598 C  C   . TRP A 1 499 ? -19.873 -56.561 -21.641 1.00 30.94  ? 762  TRP A C   1 
ATOM   3599 O  O   . TRP A 1 499 ? -18.996 -56.764 -22.468 1.00 30.29  ? 762  TRP A O   1 
ATOM   3600 C  CB  . TRP A 1 499 ? -19.361 -56.471 -19.177 1.00 25.97  ? 762  TRP A CB  1 
ATOM   3601 C  CG  . TRP A 1 499 ? -18.762 -55.736 -18.020 1.00 25.51  ? 762  TRP A CG  1 
ATOM   3602 C  CD1 . TRP A 1 499 ? -18.274 -54.464 -18.004 1.00 26.62  ? 762  TRP A CD1 1 
ATOM   3603 C  CD2 . TRP A 1 499 ? -18.576 -56.251 -16.691 1.00 26.23  ? 762  TRP A CD2 1 
ATOM   3604 N  NE1 . TRP A 1 499 ? -17.808 -54.149 -16.758 1.00 26.98  ? 762  TRP A NE1 1 
ATOM   3605 C  CE2 . TRP A 1 499 ? -17.976 -55.226 -15.932 1.00 24.04  ? 762  TRP A CE2 1 
ATOM   3606 C  CE3 . TRP A 1 499 ? -18.860 -57.471 -16.070 1.00 27.67  ? 762  TRP A CE3 1 
ATOM   3607 C  CZ2 . TRP A 1 499 ? -17.656 -55.390 -14.586 1.00 25.69  ? 762  TRP A CZ2 1 
ATOM   3608 C  CZ3 . TRP A 1 499 ? -18.545 -57.631 -14.740 1.00 26.19  ? 762  TRP A CZ3 1 
ATOM   3609 C  CH2 . TRP A 1 499 ? -17.952 -56.602 -14.011 1.00 27.32  ? 762  TRP A CH2 1 
ATOM   3610 N  N   A SER A 1 500 ? -21.140 -56.959 -21.788 0.19 27.92  ? 763  SER A N   1 
ATOM   3611 N  N   B SER A 1 500 ? -21.139 -56.966 -21.784 0.19 27.11  ? 763  SER A N   1 
ATOM   3612 C  CA  A SER A 1 500 ? -21.534 -57.876 -22.890 0.19 26.65  ? 763  SER A CA  1 
ATOM   3613 C  CA  B SER A 1 500 ? -21.532 -57.879 -22.890 0.19 25.45  ? 763  SER A CA  1 
ATOM   3614 C  C   A SER A 1 500 ? -21.413 -57.170 -24.241 0.19 25.58  ? 763  SER A C   1 
ATOM   3615 C  C   B SER A 1 500 ? -21.414 -57.170 -24.241 0.19 24.89  ? 763  SER A C   1 
ATOM   3616 O  O   A SER A 1 500 ? -21.306 -57.873 -25.261 0.19 27.12  ? 763  SER A O   1 
ATOM   3617 O  O   B SER A 1 500 ? -21.300 -57.872 -25.261 0.19 26.64  ? 763  SER A O   1 
ATOM   3618 C  CB  A SER A 1 500 ? -22.934 -58.377 -22.674 0.19 27.12  ? 763  SER A CB  1 
ATOM   3619 C  CB  B SER A 1 500 ? -22.924 -58.415 -22.676 0.19 25.06  ? 763  SER A CB  1 
ATOM   3620 O  OG  A SER A 1 500 ? -23.136 -58.710 -21.310 0.19 27.83  ? 763  SER A OG  1 
ATOM   3621 O  OG  B SER A 1 500 ? -23.885 -57.374 -22.757 0.19 24.94  ? 763  SER A OG  1 
ATOM   3622 N  N   . LEU A 1 501 ? -21.630 -55.853 -24.265 0.38 26.35  ? 764  LEU A N   1 
ATOM   3623 C  CA  . LEU A 1 501 ? -21.601 -55.099 -25.550 0.38 27.08  ? 764  LEU A CA  1 
ATOM   3624 C  C   . LEU A 1 501 ? -20.197 -54.592 -25.895 0.38 28.25  ? 764  LEU A C   1 
ATOM   3625 O  O   . LEU A 1 501 ? -19.865 -54.592 -27.087 0.38 30.06  ? 764  LEU A O   1 
ATOM   3626 C  CB  . LEU A 1 501 ? -22.583 -53.931 -25.419 0.38 26.84  ? 764  LEU A CB  1 
ATOM   3627 C  CG  . LEU A 1 501 ? -22.882 -53.171 -26.709 0.38 26.49  ? 764  LEU A CG  1 
ATOM   3628 C  CD1 . LEU A 1 501 ? -23.409 -54.113 -27.780 0.38 26.56  ? 764  LEU A CD1 1 
ATOM   3629 C  CD2 . LEU A 1 501 ? -23.872 -52.045 -26.455 0.38 27.75  ? 764  LEU A CD2 1 
ATOM   3630 N  N   . MET A 1 502 ? -19.404 -54.192 -24.903 1.00 28.25  ? 765  MET A N   1 
ATOM   3631 C  CA  . MET A 1 502 ? -18.088 -53.562 -25.181 1.00 30.27  ? 765  MET A CA  1 
ATOM   3632 C  C   . MET A 1 502 ? -16.898 -54.454 -24.818 1.00 30.12  ? 765  MET A C   1 
ATOM   3633 O  O   . MET A 1 502 ? -15.871 -54.311 -25.467 1.00 29.31  ? 765  MET A O   1 
ATOM   3634 C  CB  . MET A 1 502 ? -17.984 -52.302 -24.319 1.00 32.67  ? 765  MET A CB  1 
ATOM   3635 C  CG  . MET A 1 502 ? -19.116 -51.317 -24.507 1.00 35.31  ? 765  MET A CG  1 
ATOM   3636 S  SD  . MET A 1 502 ? -18.993 -50.387 -26.048 1.00 38.63  ? 765  MET A SD  1 
ATOM   3637 C  CE  . MET A 1 502 ? -19.821 -51.492 -27.187 1.00 47.14  ? 765  MET A CE  1 
ATOM   3638 N  N   . TYR A 1 503 ? -17.046 -55.349 -23.853 1.00 27.43  ? 766  TYR A N   1 
ATOM   3639 C  CA  . TYR A 1 503 ? -15.929 -56.128 -23.271 1.00 27.09  ? 766  TYR A CA  1 
ATOM   3640 C  C   . TYR A 1 503 ? -16.217 -57.637 -23.378 1.00 28.76  ? 766  TYR A C   1 
ATOM   3641 O  O   . TYR A 1 503 ? -15.688 -58.400 -22.545 1.00 27.78  ? 766  TYR A O   1 
ATOM   3642 C  CB  . TYR A 1 503 ? -15.701 -55.667 -21.829 1.00 29.97  ? 766  TYR A CB  1 
ATOM   3643 C  CG  . TYR A 1 503 ? -15.489 -54.177 -21.619 1.00 29.34  ? 766  TYR A CG  1 
ATOM   3644 C  CD1 . TYR A 1 503 ? -14.483 -53.479 -22.275 1.00 29.37  ? 766  TYR A CD1 1 
ATOM   3645 C  CD2 . TYR A 1 503 ? -16.295 -53.444 -20.755 1.00 31.09  ? 766  TYR A CD2 1 
ATOM   3646 C  CE1 . TYR A 1 503 ? -14.305 -52.111 -22.113 1.00 28.49  ? 766  TYR A CE1 1 
ATOM   3647 C  CE2 . TYR A 1 503 ? -16.117 -52.077 -20.568 1.00 31.12  ? 766  TYR A CE2 1 
ATOM   3648 C  CZ  . TYR A 1 503 ? -15.110 -51.409 -21.240 1.00 29.76  ? 766  TYR A CZ  1 
ATOM   3649 O  OH  . TYR A 1 503 ? -14.941 -50.083 -21.072 1.00 31.32  ? 766  TYR A OH  1 
ATOM   3650 N  N   . PHE A 1 504 ? -17.080 -58.053 -24.324 1.00 29.99  ? 767  PHE A N   1 
ATOM   3651 C  CA  . PHE A 1 504 ? -17.482 -59.468 -24.582 1.00 31.06  ? 767  PHE A CA  1 
ATOM   3652 C  C   . PHE A 1 504 ? -16.255 -60.359 -24.831 1.00 29.30  ? 767  PHE A C   1 
ATOM   3653 O  O   . PHE A 1 504 ? -16.309 -61.608 -24.660 1.00 26.95  ? 767  PHE A O   1 
ATOM   3654 C  CB  . PHE A 1 504 ? -18.354 -59.597 -25.829 1.00 28.09  ? 767  PHE A CB  1 
ATOM   3655 C  CG  . PHE A 1 504 ? -17.859 -58.843 -27.040 1.00 27.29  ? 767  PHE A CG  1 
ATOM   3656 C  CD1 . PHE A 1 504 ? -18.212 -57.532 -27.244 1.00 29.53  ? 767  PHE A CD1 1 
ATOM   3657 C  CD2 . PHE A 1 504 ? -17.056 -59.450 -27.985 1.00 28.44  ? 767  PHE A CD2 1 
ATOM   3658 C  CE1 . PHE A 1 504 ? -17.751 -56.844 -28.348 1.00 28.50  ? 767  PHE A CE1 1 
ATOM   3659 C  CE2 . PHE A 1 504 ? -16.585 -58.755 -29.083 1.00 24.99  ? 767  PHE A CE2 1 
ATOM   3660 C  CZ  . PHE A 1 504 ? -16.958 -57.461 -29.268 1.00 28.11  ? 767  PHE A CZ  1 
ATOM   3661 N  N   . HIS A 1 505 ? -15.183 -59.721 -25.271 1.00 31.42  ? 768  HIS A N   1 
ATOM   3662 C  CA  . HIS A 1 505 ? -13.914 -60.389 -25.712 1.00 31.01  ? 768  HIS A CA  1 
ATOM   3663 C  C   . HIS A 1 505 ? -13.016 -60.787 -24.522 1.00 28.57  ? 768  HIS A C   1 
ATOM   3664 O  O   . HIS A 1 505 ? -11.967 -61.428 -24.760 1.00 29.56  ? 768  HIS A O   1 
ATOM   3665 C  CB  . HIS A 1 505 ? -13.204 -59.472 -26.697 1.00 27.40  ? 768  HIS A CB  1 
ATOM   3666 C  CG  . HIS A 1 505 ? -13.043 -58.080 -26.208 1.00 28.93  ? 768  HIS A CG  1 
ATOM   3667 N  ND1 . HIS A 1 505 ? -12.009 -57.689 -25.408 1.00 28.81  ? 768  HIS A ND1 1 
ATOM   3668 C  CD2 . HIS A 1 505 ? -13.847 -56.998 -26.360 1.00 31.66  ? 768  HIS A CD2 1 
ATOM   3669 C  CE1 . HIS A 1 505 ? -12.155 -56.421 -25.121 1.00 31.92  ? 768  HIS A CE1 1 
ATOM   3670 N  NE2 . HIS A 1 505 ? -13.306 -55.972 -25.680 1.00 27.28  ? 768  HIS A NE2 1 
ATOM   3671 N  N   . ARG A 1 506 ? -13.355 -60.358 -23.303 1.00 25.05  ? 769  ARG A N   1 
ATOM   3672 C  CA  . ARG A 1 506 ? -12.652 -60.704 -22.051 1.00 26.72  ? 769  ARG A CA  1 
ATOM   3673 C  C   . ARG A 1 506 ? -13.414 -61.874 -21.403 1.00 29.42  ? 769  ARG A C   1 
ATOM   3674 O  O   . ARG A 1 506 ? -14.599 -61.689 -21.069 1.00 29.32  ? 769  ARG A O   1 
ATOM   3675 C  CB  . ARG A 1 506 ? -12.577 -59.494 -21.101 1.00 25.68  ? 769  ARG A CB  1 
ATOM   3676 C  CG  . ARG A 1 506 ? -12.159 -58.187 -21.758 1.00 28.08  ? 769  ARG A CG  1 
ATOM   3677 C  CD  . ARG A 1 506 ? -10.779 -58.231 -22.433 1.00 27.45  ? 769  ARG A CD  1 
ATOM   3678 N  NE  . ARG A 1 506 ? -9.864  -58.810 -21.472 1.00 24.29  ? 769  ARG A NE  1 
ATOM   3679 C  CZ  . ARG A 1 506 ? -9.362  -58.171 -20.420 1.00 22.91  ? 769  ARG A CZ  1 
ATOM   3680 N  NH1 . ARG A 1 506 ? -8.655  -58.820 -19.505 1.00 24.61  ? 769  ARG A NH1 1 
ATOM   3681 N  NH2 . ARG A 1 506 ? -9.507  -56.881 -20.294 1.00 24.58  ? 769  ARG A NH2 1 
ATOM   3682 N  N   . ARG A 1 507 ? -12.798 -63.054 -21.327 1.00 26.51  ? 770  ARG A N   1 
ATOM   3683 C  CA  . ARG A 1 507 ? -13.431 -64.292 -20.819 1.00 27.15  ? 770  ARG A CA  1 
ATOM   3684 C  C   . ARG A 1 507 ? -14.109 -64.036 -19.470 1.00 28.26  ? 770  ARG A C   1 
ATOM   3685 O  O   . ARG A 1 507 ? -15.292 -64.449 -19.297 1.00 28.28  ? 770  ARG A O   1 
ATOM   3686 C  CB  . ARG A 1 507 ? -12.417 -65.421 -20.706 1.00 28.27  ? 770  ARG A CB  1 
ATOM   3687 C  CG  . ARG A 1 507 ? -11.907 -65.913 -22.059 1.00 31.49  ? 770  ARG A CG  1 
ATOM   3688 C  CD  . ARG A 1 507 ? -10.611 -66.700 -21.921 1.00 30.26  ? 770  ARG A CD  1 
ATOM   3689 N  NE  . ARG A 1 507 ? -10.253 -67.218 -23.219 1.00 29.40  ? 770  ARG A NE  1 
ATOM   3690 C  CZ  . ARG A 1 507 ? -9.660  -66.494 -24.151 1.00 29.82  ? 770  ARG A CZ  1 
ATOM   3691 N  NH1 . ARG A 1 507 ? -9.345  -65.238 -23.921 1.00 26.12  ? 770  ARG A NH1 1 
ATOM   3692 N  NH2 . ARG A 1 507 ? -9.390  -67.012 -25.322 1.00 32.16  ? 770  ARG A NH2 1 
ATOM   3693 N  N   . ASP A 1 508 ? -13.452 -63.389 -18.532 1.00 25.99  ? 771  ASP A N   1 
ATOM   3694 C  CA  . ASP A 1 508 ? -14.031 -63.265 -17.167 1.00 28.85  ? 771  ASP A CA  1 
ATOM   3695 C  C   . ASP A 1 508 ? -15.274 -62.343 -17.201 1.00 30.66  ? 771  ASP A C   1 
ATOM   3696 O  O   . ASP A 1 508 ? -16.173 -62.530 -16.403 1.00 29.88  ? 771  ASP A O   1 
ATOM   3697 C  CB  . ASP A 1 508 ? -13.017 -62.683 -16.205 1.00 27.61  ? 771  ASP A CB  1 
ATOM   3698 C  CG  . ASP A 1 508 ? -11.786 -63.557 -16.004 1.00 29.23  ? 771  ASP A CG  1 
ATOM   3699 O  OD1 . ASP A 1 508 ? -11.817 -64.734 -16.401 1.00 26.14  ? 771  ASP A OD1 1 
ATOM   3700 O  OD2 . ASP A 1 508 ? -10.827 -63.055 -15.389 1.00 26.60  ? 771  ASP A OD2 1 
ATOM   3701 N  N   . LEU A 1 509 ? -15.273 -61.322 -18.058 1.00 29.39  ? 772  LEU A N   1 
ATOM   3702 C  CA  . LEU A 1 509 ? -16.356 -60.314 -18.071 1.00 29.80  ? 772  LEU A CA  1 
ATOM   3703 C  C   . LEU A 1 509 ? -17.562 -60.910 -18.797 1.00 29.87  ? 772  LEU A C   1 
ATOM   3704 O  O   . LEU A 1 509 ? -18.635 -60.594 -18.375 1.00 28.53  ? 772  LEU A O   1 
ATOM   3705 C  CB  . LEU A 1 509 ? -15.852 -58.995 -18.680 1.00 31.47  ? 772  LEU A CB  1 
ATOM   3706 C  CG  . LEU A 1 509 ? -14.723 -58.303 -17.886 1.00 28.49  ? 772  LEU A CG  1 
ATOM   3707 C  CD1 . LEU A 1 509 ? -14.456 -56.909 -18.416 1.00 30.64  ? 772  LEU A CD1 1 
ATOM   3708 C  CD2 . LEU A 1 509 ? -15.034 -58.245 -16.406 1.00 28.88  ? 772  LEU A CD2 1 
ATOM   3709 N  N   . ARG A 1 510 ? -17.396 -61.753 -19.824 1.00 29.52  ? 773  ARG A N   1 
ATOM   3710 C  CA  . ARG A 1 510 ? -18.551 -62.373 -20.505 1.00 28.72  ? 773  ARG A CA  1 
ATOM   3711 C  C   . ARG A 1 510 ? -19.213 -63.320 -19.499 1.00 32.04  ? 773  ARG A C   1 
ATOM   3712 O  O   . ARG A 1 510 ? -20.442 -63.339 -19.397 1.00 32.31  ? 773  ARG A O   1 
ATOM   3713 C  CB  . ARG A 1 510 ? -18.158 -63.122 -21.780 1.00 26.87  ? 773  ARG A CB  1 
ATOM   3714 C  CG  . ARG A 1 510 ? -19.354 -63.398 -22.694 1.00 28.52  ? 773  ARG A CG  1 
ATOM   3715 C  CD  . ARG A 1 510 ? -19.087 -64.286 -23.877 1.00 27.74  ? 773  ARG A CD  1 
ATOM   3716 N  NE  . ARG A 1 510 ? -18.211 -63.638 -24.845 1.00 27.35  ? 773  ARG A NE  1 
ATOM   3717 C  CZ  . ARG A 1 510 ? -18.062 -64.043 -26.101 1.00 30.68  ? 773  ARG A CZ  1 
ATOM   3718 N  NH1 . ARG A 1 510 ? -18.785 -65.039 -26.551 1.00 31.83  ? 773  ARG A NH1 1 
ATOM   3719 N  NH2 . ARG A 1 510 ? -17.243 -63.422 -26.930 1.00 32.47  ? 773  ARG A NH2 1 
ATOM   3720 N  N   . LEU A 1 511 ? -18.410 -64.072 -18.770 1.00 28.98  ? 774  LEU A N   1 
ATOM   3721 C  CA  . LEU A 1 511 ? -18.899 -65.016 -17.739 1.00 29.15  ? 774  LEU A CA  1 
ATOM   3722 C  C   . LEU A 1 511 ? -19.575 -64.226 -16.618 1.00 28.79  ? 774  LEU A C   1 
ATOM   3723 O  O   . LEU A 1 511 ? -20.709 -64.590 -16.254 1.00 29.55  ? 774  LEU A O   1 
ATOM   3724 C  CB  . LEU A 1 511 ? -17.754 -65.900 -17.223 1.00 30.19  ? 774  LEU A CB  1 
ATOM   3725 C  CG  . LEU A 1 511 ? -18.177 -67.165 -16.473 1.00 31.06  ? 774  LEU A CG  1 
ATOM   3726 C  CD1 . LEU A 1 511 ? -17.020 -68.106 -16.283 1.00 34.65  ? 774  LEU A CD1 1 
ATOM   3727 C  CD2 . LEU A 1 511 ? -18.796 -66.856 -15.128 1.00 31.38  ? 774  LEU A CD2 1 
ATOM   3728 N  N   . ALA A 1 512 ? -18.970 -63.182 -16.092 1.00 26.25  ? 775  ALA A N   1 
ATOM   3729 C  CA  . ALA A 1 512 ? -19.552 -62.493 -14.932 1.00 26.76  ? 775  ALA A CA  1 
ATOM   3730 C  C   . ALA A 1 512 ? -20.834 -61.765 -15.389 1.00 28.98  ? 775  ALA A C   1 
ATOM   3731 O  O   . ALA A 1 512 ? -21.774 -61.697 -14.626 1.00 30.09  ? 775  ALA A O   1 
ATOM   3732 C  CB  . ALA A 1 512 ? -18.547 -61.578 -14.277 1.00 25.68  ? 775  ALA A CB  1 
ATOM   3733 N  N   . ALA A 1 513 ? -20.858 -61.259 -16.611 1.00 28.89  ? 776  ALA A N   1 
ATOM   3734 C  CA  . ALA A 1 513 ? -22.000 -60.526 -17.174 1.00 29.60  ? 776  ALA A CA  1 
ATOM   3735 C  C   . ALA A 1 513 ? -23.171 -61.501 -17.281 1.00 32.02  ? 776  ALA A C   1 
ATOM   3736 O  O   . ALA A 1 513 ? -24.271 -61.120 -16.888 1.00 30.88  ? 776  ALA A O   1 
ATOM   3737 C  CB  . ALA A 1 513 ? -21.677 -59.918 -18.515 1.00 26.69  ? 776  ALA A CB  1 
ATOM   3738 N  N   . ASN A 1 514 ? -22.937 -62.669 -17.867 1.00 30.56  ? 777  ASN A N   1 
ATOM   3739 C  CA  . ASN A 1 514 ? -23.965 -63.720 -17.971 1.00 33.54  ? 777  ASN A CA  1 
ATOM   3740 C  C   . ASN A 1 514 ? -24.447 -64.087 -16.565 1.00 34.53  ? 777  ASN A C   1 
ATOM   3741 O  O   . ASN A 1 514 ? -25.677 -64.269 -16.346 1.00 33.52  ? 777  ASN A O   1 
ATOM   3742 C  CB  . ASN A 1 514 ? -23.456 -64.922 -18.745 1.00 33.98  ? 777  ASN A CB  1 
ATOM   3743 C  CG  . ASN A 1 514 ? -23.380 -64.644 -20.227 1.00 36.08  ? 777  ASN A CG  1 
ATOM   3744 O  OD1 . ASN A 1 514 ? -24.217 -63.942 -20.764 1.00 37.99  ? 777  ASN A OD1 1 
ATOM   3745 N  ND2 . ASN A 1 514 ? -22.430 -65.246 -20.917 1.00 38.61  ? 777  ASN A ND2 1 
ATOM   3746 N  N   . ALA A 1 515 ? -23.540 -64.246 -15.626 1.00 30.57  ? 778  ALA A N   1 
ATOM   3747 C  CA  . ALA A 1 515 ? -23.929 -64.593 -14.241 1.00 30.85  ? 778  ALA A CA  1 
ATOM   3748 C  C   . ALA A 1 515 ? -24.807 -63.483 -13.638 1.00 30.81  ? 778  ALA A C   1 
ATOM   3749 O  O   . ALA A 1 515 ? -25.781 -63.806 -13.051 1.00 30.15  ? 778  ALA A O   1 
ATOM   3750 C  CB  . ALA A 1 515 ? -22.721 -64.862 -13.394 1.00 29.61  ? 778  ALA A CB  1 
ATOM   3751 N  N   . ILE A 1 516 ? -24.438 -62.215 -13.750 1.00 31.10  ? 779  ILE A N   1 
ATOM   3752 C  CA  . ILE A 1 516 ? -25.235 -61.099 -13.169 1.00 34.92  ? 779  ILE A CA  1 
ATOM   3753 C  C   . ILE A 1 516 ? -26.616 -61.072 -13.845 1.00 36.95  ? 779  ILE A C   1 
ATOM   3754 O  O   . ILE A 1 516 ? -27.570 -60.991 -13.106 1.00 31.29  ? 779  ILE A O   1 
ATOM   3755 C  CB  . ILE A 1 516 ? -24.505 -59.742 -13.240 1.00 29.07  ? 779  ILE A CB  1 
ATOM   3756 C  CG1 . ILE A 1 516 ? -23.265 -59.730 -12.340 1.00 31.07  ? 779  ILE A CG1 1 
ATOM   3757 C  CG2 . ILE A 1 516 ? -25.418 -58.611 -12.874 1.00 27.29  ? 779  ILE A CG2 1 
ATOM   3758 C  CD1 . ILE A 1 516 ? -22.208 -58.773 -12.840 1.00 31.85  ? 779  ILE A CD1 1 
ATOM   3759 N  N   . CYS A 1 517 ? -26.708 -61.189 -15.171 1.00 31.41  ? 780  CYS A N   1 
ATOM   3760 C  CA  . CYS A 1 517 ? -27.990 -61.135 -15.898 1.00 34.86  ? 780  CYS A CA  1 
ATOM   3761 C  C   . CYS A 1 517 ? -28.852 -62.356 -15.560 1.00 38.13  ? 780  CYS A C   1 
ATOM   3762 O  O   . CYS A 1 517 ? -30.078 -62.268 -15.758 1.00 36.65  ? 780  CYS A O   1 
ATOM   3763 C  CB  . CYS A 1 517 ? -27.781 -60.991 -17.395 1.00 32.01  ? 780  CYS A CB  1 
ATOM   3764 S  SG  . CYS A 1 517 ? -27.114 -59.366 -17.803 1.00 35.69  ? 780  CYS A SG  1 
ATOM   3765 N  N   . SER A 1 518 ? -28.259 -63.434 -15.061 1.00 33.73  ? 781  SER A N   1 
ATOM   3766 C  CA  . SER A 1 518 ? -28.975 -64.652 -14.629 1.00 30.86  ? 781  SER A CA  1 
ATOM   3767 C  C   . SER A 1 518 ? -29.492 -64.477 -13.194 1.00 33.17  ? 781  SER A C   1 
ATOM   3768 O  O   . SER A 1 518 ? -30.491 -65.153 -12.850 1.00 33.11  ? 781  SER A O   1 
ATOM   3769 C  CB  . SER A 1 518 ? -28.124 -65.898 -14.715 1.00 31.07  ? 781  SER A CB  1 
ATOM   3770 O  OG  . SER A 1 518 ? -27.751 -66.224 -16.039 1.00 34.42  ? 781  SER A OG  1 
ATOM   3771 N  N   . ALA A 1 519 ? -28.834 -63.645 -12.384 1.00 33.06  ? 782  ALA A N   1 
ATOM   3772 C  CA  . ALA A 1 519 ? -29.069 -63.512 -10.920 1.00 33.34  ? 782  ALA A CA  1 
ATOM   3773 C  C   . ALA A 1 519 ? -30.075 -62.398 -10.665 1.00 32.35  ? 782  ALA A C   1 
ATOM   3774 O  O   . ALA A 1 519 ? -30.551 -62.343 -9.562  1.00 37.93  ? 782  ALA A O   1 
ATOM   3775 C  CB  . ALA A 1 519 ? -27.786 -63.258 -10.141 1.00 33.48  ? 782  ALA A CB  1 
ATOM   3776 N  N   . VAL A 1 520 ? -30.264 -61.502 -11.622 1.00 31.26  ? 783  VAL A N   1 
ATOM   3777 C  CA  . VAL A 1 520 ? -31.191 -60.344 -11.561 1.00 34.06  ? 783  VAL A CA  1 
ATOM   3778 C  C   . VAL A 1 520 ? -32.443 -60.678 -12.394 1.00 35.44  ? 783  VAL A C   1 
ATOM   3779 O  O   . VAL A 1 520 ? -32.352 -61.253 -13.493 1.00 32.28  ? 783  VAL A O   1 
ATOM   3780 C  CB  . VAL A 1 520 ? -30.517 -59.055 -12.062 1.00 37.69  ? 783  VAL A CB  1 
ATOM   3781 C  CG1 . VAL A 1 520 ? -31.448 -57.848 -11.990 1.00 37.90  ? 783  VAL A CG1 1 
ATOM   3782 C  CG2 . VAL A 1 520 ? -29.224 -58.731 -11.319 1.00 37.19  ? 783  VAL A CG2 1 
ATOM   3783 N  N   . PRO A 1 521 ? -33.659 -60.379 -11.876 1.00 32.98  ? 784  PRO A N   1 
ATOM   3784 C  CA  . PRO A 1 521 ? -34.898 -60.660 -12.607 1.00 33.74  ? 784  PRO A CA  1 
ATOM   3785 C  C   . PRO A 1 521 ? -34.754 -60.278 -14.085 1.00 33.90  ? 784  PRO A C   1 
ATOM   3786 O  O   . PRO A 1 521 ? -34.554 -59.116 -14.320 1.00 35.97  ? 784  PRO A O   1 
ATOM   3787 C  CB  . PRO A 1 521 ? -35.945 -59.885 -11.798 1.00 33.98  ? 784  PRO A CB  1 
ATOM   3788 C  CG  . PRO A 1 521 ? -35.434 -59.997 -10.390 1.00 37.79  ? 784  PRO A CG  1 
ATOM   3789 C  CD  . PRO A 1 521 ? -33.938 -59.822 -10.545 1.00 36.80  ? 784  PRO A CD  1 
ATOM   3790 N  N   A SER A 1 522 ? -35.248 -61.134 -14.982 0.19 35.07  ? 785  SER A N   1 
ATOM   3791 N  N   B SER A 1 522 ? -35.253 -61.131 -14.981 0.19 34.05  ? 785  SER A N   1 
ATOM   3792 C  CA  A SER A 1 522 ? -35.095 -60.879 -16.441 0.19 38.16  ? 785  SER A CA  1 
ATOM   3793 C  CA  B SER A 1 522 ? -35.098 -60.879 -16.440 0.19 36.43  ? 785  SER A CA  1 
ATOM   3794 C  C   A SER A 1 522 ? -35.694 -59.538 -16.874 0.19 38.80  ? 785  SER A C   1 
ATOM   3795 C  C   B SER A 1 522 ? -35.693 -59.537 -16.872 0.19 37.75  ? 785  SER A C   1 
ATOM   3796 O  O   A SER A 1 522 ? -35.188 -58.972 -17.859 0.19 37.96  ? 785  SER A O   1 
ATOM   3797 O  O   B SER A 1 522 ? -35.190 -58.977 -17.861 0.19 36.93  ? 785  SER A O   1 
ATOM   3798 C  CB  A SER A 1 522 ? -35.702 -62.013 -17.225 0.19 41.83  ? 785  SER A CB  1 
ATOM   3799 C  CB  B SER A 1 522 ? -35.725 -62.007 -17.212 0.19 38.74  ? 785  SER A CB  1 
ATOM   3800 O  OG  A SER A 1 522 ? -37.073 -62.175 -16.895 0.19 44.56  ? 785  SER A OG  1 
ATOM   3801 O  OG  B SER A 1 522 ? -35.456 -63.252 -16.586 0.19 38.53  ? 785  SER A OG  1 
ATOM   3802 N  N   . HIS A 1 523 ? -36.848 -59.162 -16.315 1.00 37.98  ? 786  HIS A N   1 
ATOM   3803 C  CA  . HIS A 1 523 ? -37.530 -57.912 -16.762 1.00 38.63  ? 786  HIS A CA  1 
ATOM   3804 C  C   . HIS A 1 523 ? -37.162 -56.652 -15.963 1.00 39.46  ? 786  HIS A C   1 
ATOM   3805 O  O   . HIS A 1 523 ? -37.655 -55.588 -16.344 1.00 41.59  ? 786  HIS A O   1 
ATOM   3806 C  CB  . HIS A 1 523 ? -39.045 -58.162 -16.814 1.00 42.79  ? 786  HIS A CB  1 
ATOM   3807 C  CG  . HIS A 1 523 ? -39.416 -59.332 -17.659 1.00 39.88  ? 786  HIS A CG  1 
ATOM   3808 N  ND1 . HIS A 1 523 ? -39.498 -59.251 -19.030 1.00 43.13  ? 786  HIS A ND1 1 
ATOM   3809 C  CD2 . HIS A 1 523 ? -39.710 -60.607 -17.335 1.00 46.48  ? 786  HIS A CD2 1 
ATOM   3810 C  CE1 . HIS A 1 523 ? -39.835 -60.425 -19.517 1.00 48.09  ? 786  HIS A CE1 1 
ATOM   3811 N  NE2 . HIS A 1 523 ? -39.972 -61.274 -18.498 1.00 45.35  ? 786  HIS A NE2 1 
ATOM   3812 N  N   . TRP A 1 524 ? -36.317 -56.740 -14.938 1.00 36.70  ? 787  TRP A N   1 
ATOM   3813 C  CA  . TRP A 1 524 ? -35.904 -55.497 -14.229 1.00 37.74  ? 787  TRP A CA  1 
ATOM   3814 C  C   . TRP A 1 524 ? -35.074 -54.604 -15.160 1.00 38.00  ? 787  TRP A C   1 
ATOM   3815 O  O   . TRP A 1 524 ? -34.229 -55.138 -15.883 1.00 38.11  ? 787  TRP A O   1 
ATOM   3816 C  CB  . TRP A 1 524 ? -35.223 -55.814 -12.895 1.00 36.89  ? 787  TRP A CB  1 
ATOM   3817 C  CG  . TRP A 1 524 ? -36.188 -56.329 -11.871 1.00 39.89  ? 787  TRP A CG  1 
ATOM   3818 C  CD1 . TRP A 1 524 ? -37.498 -56.650 -12.073 1.00 41.84  ? 787  TRP A CD1 1 
ATOM   3819 C  CD2 . TRP A 1 524 ? -35.927 -56.582 -10.480 1.00 40.35  ? 787  TRP A CD2 1 
ATOM   3820 N  NE1 . TRP A 1 524 ? -38.067 -57.088 -10.910 1.00 38.30  ? 787  TRP A NE1 1 
ATOM   3821 C  CE2 . TRP A 1 524 ? -37.130 -57.055 -9.915  1.00 38.08  ? 787  TRP A CE2 1 
ATOM   3822 C  CE3 . TRP A 1 524 ? -34.802 -56.460 -9.660  1.00 38.25  ? 787  TRP A CE3 1 
ATOM   3823 C  CZ2 . TRP A 1 524 ? -37.235 -57.403 -8.571  1.00 37.70  ? 787  TRP A CZ2 1 
ATOM   3824 C  CZ3 . TRP A 1 524 ? -34.907 -56.805 -8.333  1.00 37.91  ? 787  TRP A CZ3 1 
ATOM   3825 C  CH2 . TRP A 1 524 ? -36.107 -57.269 -7.797  1.00 37.46  ? 787  TRP A CH2 1 
ATOM   3826 N  N   . VAL A 1 525 ? -35.324 -53.296 -15.137 0.38 37.44  ? 788  VAL A N   1 
ATOM   3827 C  CA  . VAL A 1 525 ? -34.665 -52.382 -16.115 0.38 38.81  ? 788  VAL A CA  1 
ATOM   3828 C  C   . VAL A 1 525 ? -33.326 -51.870 -15.582 0.38 38.51  ? 788  VAL A C   1 
ATOM   3829 O  O   . VAL A 1 525 ? -33.293 -51.351 -14.455 0.38 38.87  ? 788  VAL A O   1 
ATOM   3830 C  CB  . VAL A 1 525 ? -35.602 -51.212 -16.476 0.38 39.24  ? 788  VAL A CB  1 
ATOM   3831 C  CG1 . VAL A 1 525 ? -34.946 -50.239 -17.442 0.38 39.06  ? 788  VAL A CG1 1 
ATOM   3832 C  CG2 . VAL A 1 525 ? -36.932 -51.703 -17.024 0.38 38.81  ? 788  VAL A CG2 1 
ATOM   3833 N  N   . PRO A 1 526 ? -32.225 -52.002 -16.350 0.38 40.35  ? 789  PRO A N   1 
ATOM   3834 C  CA  . PRO A 1 526 ? -30.938 -51.431 -15.951 0.38 39.78  ? 789  PRO A CA  1 
ATOM   3835 C  C   . PRO A 1 526 ? -31.027 -49.932 -15.631 0.38 41.20  ? 789  PRO A C   1 
ATOM   3836 O  O   . PRO A 1 526 ? -31.519 -49.198 -16.471 0.38 39.51  ? 789  PRO A O   1 
ATOM   3837 C  CB  . PRO A 1 526 ? -30.062 -51.623 -17.194 0.38 38.88  ? 789  PRO A CB  1 
ATOM   3838 C  CG  . PRO A 1 526 ? -30.672 -52.802 -17.919 0.38 39.71  ? 789  PRO A CG  1 
ATOM   3839 C  CD  . PRO A 1 526 ? -32.154 -52.739 -17.619 0.38 40.03  ? 789  PRO A CD  1 
ATOM   3840 N  N   . THR A 1 527 ? -30.533 -49.515 -14.460 0.38 43.61  ? 790  THR A N   1 
ATOM   3841 C  CA  . THR A 1 527 ? -30.588 -48.108 -13.979 0.38 48.10  ? 790  THR A CA  1 
ATOM   3842 C  C   . THR A 1 527 ? -29.177 -47.543 -13.813 0.38 48.12  ? 790  THR A C   1 
ATOM   3843 O  O   . THR A 1 527 ? -28.271 -48.320 -13.472 0.38 47.22  ? 790  THR A O   1 
ATOM   3844 C  CB  . THR A 1 527 ? -31.359 -47.991 -12.658 0.38 52.35  ? 790  THR A CB  1 
ATOM   3845 O  OG1 . THR A 1 527 ? -30.694 -48.763 -11.656 0.38 57.00  ? 790  THR A OG1 1 
ATOM   3846 C  CG2 . THR A 1 527 ? -32.796 -48.449 -12.783 0.38 54.51  ? 790  THR A CG2 1 
ATOM   3847 N  N   . SER A 1 528 ? -29.033 -46.234 -14.047 0.38 51.24  ? 791  SER A N   1 
ATOM   3848 C  CA  . SER A 1 528 ? -27.833 -45.401 -13.769 0.38 52.60  ? 791  SER A CA  1 
ATOM   3849 C  C   . SER A 1 528 ? -26.550 -46.151 -14.137 0.38 54.07  ? 791  SER A C   1 
ATOM   3850 O  O   . SER A 1 528 ? -25.482 -45.522 -14.000 0.38 55.39  ? 791  SER A O   1 
ATOM   3851 C  CB  . SER A 1 528 ? -27.808 -44.961 -12.328 0.38 55.52  ? 791  SER A CB  1 
ATOM   3852 O  OG  . SER A 1 528 ? -28.869 -44.055 -12.057 0.38 54.93  ? 791  SER A OG  1 
ATOM   3853 N  N   . THR A 1 537 ? -23.539 -42.740 -25.571 0.38 67.08  ? 800  THR A N   1 
ATOM   3854 C  CA  . THR A 1 537 ? -24.380 -43.699 -26.341 0.38 66.17  ? 800  THR A CA  1 
ATOM   3855 C  C   . THR A 1 537 ? -25.205 -44.562 -25.378 0.38 63.34  ? 800  THR A C   1 
ATOM   3856 O  O   . THR A 1 537 ? -26.442 -44.389 -25.327 0.38 67.41  ? 800  THR A O   1 
ATOM   3857 C  CB  . THR A 1 537 ? -23.512 -44.591 -27.234 0.38 65.43  ? 800  THR A CB  1 
ATOM   3858 O  OG1 . THR A 1 537 ? -22.600 -45.282 -26.377 0.38 66.27  ? 800  THR A OG1 1 
ATOM   3859 C  CG2 . THR A 1 537 ? -22.770 -43.810 -28.298 0.38 63.52  ? 800  THR A CG2 1 
ATOM   3860 N  N   . HIS A 1 538 ? -24.540 -45.474 -24.665 0.38 58.36  ? 801  HIS A N   1 
ATOM   3861 C  CA  . HIS A 1 538 ? -25.136 -46.314 -23.594 0.38 51.73  ? 801  HIS A CA  1 
ATOM   3862 C  C   . HIS A 1 538 ? -26.264 -47.173 -24.172 0.38 46.65  ? 801  HIS A C   1 
ATOM   3863 O  O   . HIS A 1 538 ? -27.361 -47.210 -23.575 0.38 42.17  ? 801  HIS A O   1 
ATOM   3864 C  CB  . HIS A 1 538 ? -25.567 -45.410 -22.438 0.38 51.77  ? 801  HIS A CB  1 
ATOM   3865 C  CG  . HIS A 1 538 ? -24.400 -44.805 -21.735 0.38 50.90  ? 801  HIS A CG  1 
ATOM   3866 N  ND1 . HIS A 1 538 ? -24.218 -44.915 -20.369 0.38 50.87  ? 801  HIS A ND1 1 
ATOM   3867 C  CD2 . HIS A 1 538 ? -23.334 -44.124 -22.211 0.38 50.03  ? 801  HIS A CD2 1 
ATOM   3868 C  CE1 . HIS A 1 538 ? -23.101 -44.302 -20.029 0.38 51.66  ? 801  HIS A CE1 1 
ATOM   3869 N  NE2 . HIS A 1 538 ? -22.539 -43.807 -21.142 0.38 51.29  ? 801  HIS A NE2 1 
ATOM   3870 N  N   . GLU A 1 539 ? -25.973 -47.873 -25.271 0.38 44.35  ? 802  GLU A N   1 
ATOM   3871 C  CA  . GLU A 1 539 ? -26.924 -48.780 -25.962 0.38 45.93  ? 802  GLU A CA  1 
ATOM   3872 C  C   . GLU A 1 539 ? -27.174 -50.019 -25.097 0.38 45.49  ? 802  GLU A C   1 
ATOM   3873 O  O   . GLU A 1 539 ? -28.042 -50.828 -25.480 0.38 46.74  ? 802  GLU A O   1 
ATOM   3874 C  CB  . GLU A 1 539 ? -26.379 -49.173 -27.333 0.38 46.58  ? 802  GLU A CB  1 
ATOM   3875 C  CG  . GLU A 1 539 ? -25.692 -48.031 -28.053 0.38 45.89  ? 802  GLU A CG  1 
ATOM   3876 C  CD  . GLU A 1 539 ? -24.225 -47.868 -27.701 0.38 46.58  ? 802  GLU A CD  1 
ATOM   3877 O  OE1 . GLU A 1 539 ? -23.383 -48.143 -28.581 0.38 49.23  ? 802  GLU A OE1 1 
ATOM   3878 O  OE2 . GLU A 1 539 ? -23.924 -47.465 -26.557 0.38 44.61  ? 802  GLU A OE2 1 
ATOM   3879 N  N   . TRP A 1 540 ? -26.458 -50.155 -23.975 0.50 44.35  ? 803  TRP A N   1 
ATOM   3880 C  CA  . TRP A 1 540 ? -26.639 -51.278 -23.016 0.50 46.54  ? 803  TRP A CA  1 
ATOM   3881 C  C   . TRP A 1 540 ? -27.776 -50.957 -22.036 0.50 48.06  ? 803  TRP A C   1 
ATOM   3882 O  O   . TRP A 1 540 ? -28.202 -51.871 -21.317 0.50 47.24  ? 803  TRP A O   1 
ATOM   3883 C  CB  . TRP A 1 540 ? -25.326 -51.615 -22.286 0.50 46.53  ? 803  TRP A CB  1 
ATOM   3884 C  CG  . TRP A 1 540 ? -24.719 -50.492 -21.500 0.50 44.31  ? 803  TRP A CG  1 
ATOM   3885 C  CD1 . TRP A 1 540 ? -25.007 -50.134 -20.214 0.50 44.89  ? 803  TRP A CD1 1 
ATOM   3886 C  CD2 . TRP A 1 540 ? -23.689 -49.590 -21.944 0.50 43.48  ? 803  TRP A CD2 1 
ATOM   3887 N  NE1 . TRP A 1 540 ? -24.246 -49.060 -19.835 0.50 44.41  ? 803  TRP A NE1 1 
ATOM   3888 C  CE2 . TRP A 1 540 ? -23.427 -48.704 -20.875 0.50 44.71  ? 803  TRP A CE2 1 
ATOM   3889 C  CE3 . TRP A 1 540 ? -22.978 -49.432 -23.138 0.50 45.15  ? 803  TRP A CE3 1 
ATOM   3890 C  CZ2 . TRP A 1 540 ? -22.472 -47.690 -20.968 0.50 46.67  ? 803  TRP A CZ2 1 
ATOM   3891 C  CZ3 . TRP A 1 540 ? -22.036 -48.432 -23.228 0.50 46.83  ? 803  TRP A CZ3 1 
ATOM   3892 C  CH2 . TRP A 1 540 ? -21.788 -47.574 -22.157 0.50 46.76  ? 803  TRP A CH2 1 
ATOM   3893 N  N   . MET A 1 541 ? -28.257 -49.711 -22.014 0.50 52.87  ? 804  MET A N   1 
ATOM   3894 C  CA  . MET A 1 541 ? -29.378 -49.275 -21.137 0.50 55.39  ? 804  MET A CA  1 
ATOM   3895 C  C   . MET A 1 541 ? -30.713 -49.611 -21.822 0.50 54.98  ? 804  MET A C   1 
ATOM   3896 O  O   . MET A 1 541 ? -31.309 -48.706 -22.435 0.50 55.89  ? 804  MET A O   1 
ATOM   3897 C  CB  . MET A 1 541 ? -29.299 -47.773 -20.844 0.50 57.14  ? 804  MET A CB  1 
ATOM   3898 C  CG  . MET A 1 541 ? -28.021 -47.353 -20.136 0.50 59.35  ? 804  MET A CG  1 
ATOM   3899 S  SD  . MET A 1 541 ? -27.768 -48.203 -18.552 0.50 61.15  ? 804  MET A SD  1 
ATOM   3900 C  CE  . MET A 1 541 ? -29.000 -47.400 -17.528 0.50 64.63  ? 804  MET A CE  1 
ATOM   3901 N  N   . THR A 1 542 ? -31.152 -50.872 -21.719 0.50 52.58  ? 805  THR A N   1 
ATOM   3902 C  CA  . THR A 1 542 ? -32.345 -51.434 -22.413 0.50 52.91  ? 805  THR A CA  1 
ATOM   3903 C  C   . THR A 1 542 ? -32.671 -52.815 -21.833 0.50 50.94  ? 805  THR A C   1 
ATOM   3904 O  O   . THR A 1 542 ? -31.776 -53.409 -21.193 0.50 49.89  ? 805  THR A O   1 
ATOM   3905 C  CB  . THR A 1 542 ? -32.117 -51.566 -23.925 0.50 54.84  ? 805  THR A CB  1 
ATOM   3906 O  OG1 . THR A 1 542 ? -33.218 -52.290 -24.477 0.50 55.18  ? 805  THR A OG1 1 
ATOM   3907 C  CG2 . THR A 1 542 ? -30.830 -52.288 -24.263 0.50 55.27  ? 805  THR A CG2 1 
ATOM   3908 N  N   . THR A 1 543 ? -33.892 -53.307 -22.069 0.38 45.47  ? 806  THR A N   1 
ATOM   3909 C  CA  . THR A 1 543 ? -34.372 -54.644 -21.626 0.38 46.67  ? 806  THR A CA  1 
ATOM   3910 C  C   . THR A 1 543 ? -34.359 -55.617 -22.813 0.38 44.64  ? 806  THR A C   1 
ATOM   3911 O  O   . THR A 1 543 ? -34.488 -56.834 -22.585 0.38 43.93  ? 806  THR A O   1 
ATOM   3912 C  CB  . THR A 1 543 ? -35.757 -54.529 -20.980 0.38 48.33  ? 806  THR A CB  1 
ATOM   3913 O  OG1 . THR A 1 543 ? -36.599 -53.881 -21.935 0.38 46.69  ? 806  THR A OG1 1 
ATOM   3914 C  CG2 . THR A 1 543 ? -35.725 -53.762 -19.674 0.38 48.79  ? 806  THR A CG2 1 
ATOM   3915 N  N   . GLU A 1 544 ? -34.199 -55.095 -24.030 0.50 43.52  ? 807  GLU A N   1 
ATOM   3916 C  CA  . GLU A 1 544 ? -33.997 -55.895 -25.266 0.50 43.61  ? 807  GLU A CA  1 
ATOM   3917 C  C   . GLU A 1 544 ? -32.901 -56.947 -25.045 0.50 42.28  ? 807  GLU A C   1 
ATOM   3918 O  O   . GLU A 1 544 ? -31.996 -56.722 -24.197 0.50 41.60  ? 807  GLU A O   1 
ATOM   3919 C  CB  . GLU A 1 544 ? -33.619 -54.973 -26.420 0.50 45.42  ? 807  GLU A CB  1 
ATOM   3920 C  CG  . GLU A 1 544 ? -33.568 -55.679 -27.756 0.50 47.65  ? 807  GLU A CG  1 
ATOM   3921 C  CD  . GLU A 1 544 ? -33.322 -54.720 -28.907 0.50 50.30  ? 807  GLU A CD  1 
ATOM   3922 O  OE1 . GLU A 1 544 ? -33.506 -55.134 -30.077 0.50 50.02  ? 807  GLU A OE1 1 
ATOM   3923 O  OE2 . GLU A 1 544 ? -32.956 -53.555 -28.624 0.50 46.18  ? 807  GLU A OE2 1 
ATOM   3924 N  N   . ASP A 1 545 ? -32.994 -58.065 -25.770 0.38 40.42  ? 808  ASP A N   1 
ATOM   3925 C  CA  . ASP A 1 545 ? -31.965 -59.135 -25.810 0.38 40.27  ? 808  ASP A CA  1 
ATOM   3926 C  C   . ASP A 1 545 ? -30.614 -58.463 -26.087 0.38 38.20  ? 808  ASP A C   1 
ATOM   3927 O  O   . ASP A 1 545 ? -30.582 -57.516 -26.894 0.38 34.18  ? 808  ASP A O   1 
ATOM   3928 C  CB  . ASP A 1 545 ? -32.327 -60.193 -26.856 0.38 42.26  ? 808  ASP A CB  1 
ATOM   3929 C  CG  . ASP A 1 545 ? -31.151 -61.034 -27.323 0.38 45.08  ? 808  ASP A CG  1 
ATOM   3930 O  OD1 . ASP A 1 545 ? -30.802 -60.934 -28.511 0.38 46.62  ? 808  ASP A OD1 1 
ATOM   3931 O  OD2 . ASP A 1 545 ? -30.595 -61.786 -26.496 0.38 53.38  ? 808  ASP A OD2 1 
ATOM   3932 N  N   . MET A 1 546 ? -29.543 -58.903 -25.423 0.38 37.97  ? 809  MET A N   1 
ATOM   3933 C  CA  . MET A 1 546 ? -28.204 -58.274 -25.579 0.38 37.93  ? 809  MET A CA  1 
ATOM   3934 C  C   . MET A 1 546 ? -27.603 -58.712 -26.916 0.38 34.89  ? 809  MET A C   1 
ATOM   3935 O  O   . MET A 1 546 ? -26.960 -57.872 -27.554 0.38 34.71  ? 809  MET A O   1 
ATOM   3936 C  CB  . MET A 1 546 ? -27.266 -58.618 -24.420 0.38 40.14  ? 809  MET A CB  1 
ATOM   3937 C  CG  . MET A 1 546 ? -27.496 -57.749 -23.184 0.38 40.81  ? 809  MET A CG  1 
ATOM   3938 S  SD  . MET A 1 546 ? -27.319 -55.964 -23.489 0.38 45.75  ? 809  MET A SD  1 
ATOM   3939 C  CE  . MET A 1 546 ? -28.991 -55.532 -23.958 0.38 45.91  ? 809  MET A CE  1 
ATOM   3940 N  N   . LEU A 1 547 ? -27.868 -59.939 -27.371 0.50 34.90  ? 810  LEU A N   1 
ATOM   3941 C  CA  . LEU A 1 547 ? -27.370 -60.407 -28.696 0.50 35.97  ? 810  LEU A CA  1 
ATOM   3942 C  C   . LEU A 1 547 ? -27.932 -59.508 -29.803 0.50 36.27  ? 810  LEU A C   1 
ATOM   3943 O  O   . LEU A 1 547 ? -27.171 -59.155 -30.712 0.50 35.71  ? 810  LEU A O   1 
ATOM   3944 C  CB  . LEU A 1 547 ? -27.754 -61.866 -28.946 0.50 37.14  ? 810  LEU A CB  1 
ATOM   3945 C  CG  . LEU A 1 547 ? -27.149 -62.466 -30.217 0.50 38.60  ? 810  LEU A CG  1 
ATOM   3946 C  CD1 . LEU A 1 547 ? -25.638 -62.277 -30.236 0.50 39.11  ? 810  LEU A CD1 1 
ATOM   3947 C  CD2 . LEU A 1 547 ? -27.502 -63.935 -30.354 0.50 39.35  ? 810  LEU A CD2 1 
ATOM   3948 N  N   . THR A 1 548 ? -29.222 -59.167 -29.747 0.50 35.15  ? 811  THR A N   1 
ATOM   3949 C  CA  . THR A 1 548 ? -29.886 -58.317 -30.769 0.50 35.73  ? 811  THR A CA  1 
ATOM   3950 C  C   . THR A 1 548 ? -29.291 -56.900 -30.719 0.50 33.57  ? 811  THR A C   1 
ATOM   3951 O  O   . THR A 1 548 ? -29.159 -56.286 -31.784 0.50 32.50  ? 811  THR A O   1 
ATOM   3952 C  CB  . THR A 1 548 ? -31.413 -58.341 -30.606 0.50 36.21  ? 811  THR A CB  1 
ATOM   3953 O  OG1 . THR A 1 548 ? -31.854 -59.644 -30.998 0.50 35.18  ? 811  THR A OG1 1 
ATOM   3954 C  CG2 . THR A 1 548 ? -32.113 -57.290 -31.440 0.50 36.72  ? 811  THR A CG2 1 
ATOM   3955 N  N   . VAL A 1 549 ? -28.989 -56.381 -29.528 1.00 31.37  ? 812  VAL A N   1 
ATOM   3956 C  CA  . VAL A 1 549 ? -28.246 -55.101 -29.400 1.00 36.93  ? 812  VAL A CA  1 
ATOM   3957 C  C   . VAL A 1 549 ? -26.816 -55.250 -29.942 1.00 34.35  ? 812  VAL A C   1 
ATOM   3958 O  O   . VAL A 1 549 ? -26.381 -54.379 -30.719 1.00 33.69  ? 812  VAL A O   1 
ATOM   3959 C  CB  . VAL A 1 549 ? -28.221 -54.595 -27.956 1.00 38.58  ? 812  VAL A CB  1 
ATOM   3960 C  CG1 . VAL A 1 549 ? -27.483 -53.267 -27.930 1.00 37.62  ? 812  VAL A CG1 1 
ATOM   3961 C  CG2 . VAL A 1 549 ? -29.644 -54.433 -27.426 1.00 45.78  ? 812  VAL A CG2 1 
ATOM   3962 N  N   . TRP A 1 550 ? -26.154 -56.365 -29.644 1.00 34.19  ? 813  TRP A N   1 
ATOM   3963 C  CA  . TRP A 1 550 ? -24.786 -56.638 -30.156 1.00 34.66  ? 813  TRP A CA  1 
ATOM   3964 C  C   . TRP A 1 550 ? -24.802 -56.477 -31.678 1.00 38.30  ? 813  TRP A C   1 
ATOM   3965 O  O   . TRP A 1 550 ? -24.003 -55.692 -32.217 1.00 34.57  ? 813  TRP A O   1 
ATOM   3966 C  CB  . TRP A 1 550 ? -24.267 -58.011 -29.694 1.00 32.95  ? 813  TRP A CB  1 
ATOM   3967 C  CG  . TRP A 1 550 ? -22.799 -58.167 -29.940 1.00 32.51  ? 813  TRP A CG  1 
ATOM   3968 C  CD1 . TRP A 1 550 ? -21.786 -57.975 -29.044 1.00 35.18  ? 813  TRP A CD1 1 
ATOM   3969 C  CD2 . TRP A 1 550 ? -22.168 -58.529 -31.172 1.00 32.49  ? 813  TRP A CD2 1 
ATOM   3970 N  NE1 . TRP A 1 550 ? -20.565 -58.193 -29.630 1.00 35.83  ? 813  TRP A NE1 1 
ATOM   3971 C  CE2 . TRP A 1 550 ? -20.766 -58.520 -30.941 1.00 35.45  ? 813  TRP A CE2 1 
ATOM   3972 C  CE3 . TRP A 1 550 ? -22.633 -58.943 -32.420 1.00 35.66  ? 813  TRP A CE3 1 
ATOM   3973 C  CZ2 . TRP A 1 550 ? -19.845 -58.831 -31.927 1.00 32.27  ? 813  TRP A CZ2 1 
ATOM   3974 C  CZ3 . TRP A 1 550 ? -21.718 -59.254 -33.400 1.00 34.14  ? 813  TRP A CZ3 1 
ATOM   3975 C  CH2 . TRP A 1 550 ? -20.349 -59.194 -33.155 1.00 35.58  ? 813  TRP A CH2 1 
ATOM   3976 N  N   . ASN A 1 551 ? -25.699 -57.199 -32.340 1.00 37.26  ? 814  ASN A N   1 
ATOM   3977 C  CA  . ASN A 1 551 ? -25.842 -57.239 -33.812 1.00 37.01  ? 814  ASN A CA  1 
ATOM   3978 C  C   . ASN A 1 551 ? -26.106 -55.843 -34.359 1.00 36.17  ? 814  ASN A C   1 
ATOM   3979 O  O   . ASN A 1 551 ? -25.612 -55.526 -35.454 1.00 35.99  ? 814  ASN A O   1 
ATOM   3980 C  CB  . ASN A 1 551 ? -26.992 -58.162 -34.250 1.00 40.14  ? 814  ASN A CB  1 
ATOM   3981 C  CG  . ASN A 1 551 ? -26.515 -59.581 -34.461 1.00 43.45  ? 814  ASN A CG  1 
ATOM   3982 O  OD1 . ASN A 1 551 ? -25.620 -59.828 -35.282 1.00 49.19  ? 814  ASN A OD1 1 
ATOM   3983 N  ND2 . ASN A 1 551 ? -27.061 -60.513 -33.688 1.00 47.03  ? 814  ASN A ND2 1 
ATOM   3984 N  N   . ARG A 1 552 ? -26.953 -55.068 -33.702 1.00 33.30  ? 815  ARG A N   1 
ATOM   3985 C  CA  . ARG A 1 552 ? -27.246 -53.723 -34.212 1.00 36.39  ? 815  ARG A CA  1 
ATOM   3986 C  C   . ARG A 1 552 ? -25.963 -52.866 -34.133 1.00 39.43  ? 815  ARG A C   1 
ATOM   3987 O  O   . ARG A 1 552 ? -25.675 -52.086 -35.104 1.00 42.03  ? 815  ARG A O   1 
ATOM   3988 C  CB  . ARG A 1 552 ? -28.394 -53.115 -33.414 1.00 38.83  ? 815  ARG A CB  1 
ATOM   3989 C  CG  . ARG A 1 552 ? -28.886 -51.789 -33.969 1.00 43.77  ? 815  ARG A CG  1 
ATOM   3990 C  CD  . ARG A 1 552 ? -29.903 -51.146 -33.031 1.00 51.21  ? 815  ARG A CD  1 
ATOM   3991 N  NE  . ARG A 1 552 ? -31.037 -52.042 -32.939 1.00 59.91  ? 815  ARG A NE  1 
ATOM   3992 C  CZ  . ARG A 1 552 ? -31.570 -52.558 -31.824 1.00 64.33  ? 815  ARG A CZ  1 
ATOM   3993 N  NH1 . ARG A 1 552 ? -31.125 -52.245 -30.614 1.00 56.21  ? 815  ARG A NH1 1 
ATOM   3994 N  NH2 . ARG A 1 552 ? -32.597 -53.383 -31.961 1.00 67.89  ? 815  ARG A NH2 1 
ATOM   3995 N  N   . VAL A 1 553 ? -25.238 -52.956 -33.014 1.00 35.11  ? 816  VAL A N   1 
ATOM   3996 C  CA  . VAL A 1 553 ? -24.091 -52.054 -32.705 1.00 37.42  ? 816  VAL A CA  1 
ATOM   3997 C  C   . VAL A 1 553 ? -22.872 -52.465 -33.540 1.00 33.82  ? 816  VAL A C   1 
ATOM   3998 O  O   . VAL A 1 553 ? -22.261 -51.586 -34.154 1.00 39.51  ? 816  VAL A O   1 
ATOM   3999 C  CB  . VAL A 1 553 ? -23.791 -52.038 -31.196 1.00 37.18  ? 816  VAL A CB  1 
ATOM   4000 C  CG1 . VAL A 1 553 ? -22.511 -51.296 -30.912 1.00 42.69  ? 816  VAL A CG1 1 
ATOM   4001 C  CG2 . VAL A 1 553 ? -24.935 -51.419 -30.430 1.00 33.90  ? 816  VAL A CG2 1 
ATOM   4002 N  N   . TRP A 1 554 ? -22.547 -53.751 -33.612 1.00 32.98  ? 817  TRP A N   1 
ATOM   4003 C  CA  . TRP A 1 554 ? -21.256 -54.218 -34.167 1.00 32.33  ? 817  TRP A CA  1 
ATOM   4004 C  C   . TRP A 1 554 ? -21.410 -54.595 -35.631 1.00 36.64  ? 817  TRP A C   1 
ATOM   4005 O  O   . TRP A 1 554 ? -20.409 -54.612 -36.295 1.00 31.58  ? 817  TRP A O   1 
ATOM   4006 C  CB  . TRP A 1 554 ? -20.692 -55.384 -33.366 1.00 32.90  ? 817  TRP A CB  1 
ATOM   4007 C  CG  . TRP A 1 554 ? -20.190 -54.943 -32.036 1.00 35.51  ? 817  TRP A CG  1 
ATOM   4008 C  CD1 . TRP A 1 554 ? -20.786 -55.108 -30.834 1.00 29.87  ? 817  TRP A CD1 1 
ATOM   4009 C  CD2 . TRP A 1 554 ? -18.960 -54.231 -31.788 1.00 30.48  ? 817  TRP A CD2 1 
ATOM   4010 N  NE1 . TRP A 1 554 ? -19.994 -54.584 -29.845 1.00 29.95  ? 817  TRP A NE1 1 
ATOM   4011 C  CE2 . TRP A 1 554 ? -18.899 -53.986 -30.401 1.00 33.38  ? 817  TRP A CE2 1 
ATOM   4012 C  CE3 . TRP A 1 554 ? -17.934 -53.757 -32.594 1.00 33.12  ? 817  TRP A CE3 1 
ATOM   4013 C  CZ2 . TRP A 1 554 ? -17.840 -53.296 -29.807 1.00 31.09  ? 817  TRP A CZ2 1 
ATOM   4014 C  CZ3 . TRP A 1 554 ? -16.877 -53.069 -32.008 1.00 32.16  ? 817  TRP A CZ3 1 
ATOM   4015 C  CH2 . TRP A 1 554 ? -16.822 -52.873 -30.629 1.00 28.90  ? 817  TRP A CH2 1 
ATOM   4016 N  N   . ILE A 1 555 ? -22.618 -54.917 -36.104 1.00 39.51  ? 818  ILE A N   1 
ATOM   4017 C  CA  . ILE A 1 555 ? -22.809 -55.365 -37.517 1.00 37.10  ? 818  ILE A CA  1 
ATOM   4018 C  C   . ILE A 1 555 ? -23.637 -54.302 -38.246 1.00 42.25  ? 818  ILE A C   1 
ATOM   4019 O  O   . ILE A 1 555 ? -23.082 -53.610 -39.090 1.00 35.72  ? 818  ILE A O   1 
ATOM   4020 C  CB  . ILE A 1 555 ? -23.495 -56.742 -37.597 1.00 40.06  ? 818  ILE A CB  1 
ATOM   4021 C  CG1 . ILE A 1 555 ? -22.841 -57.802 -36.712 1.00 42.50  ? 818  ILE A CG1 1 
ATOM   4022 C  CG2 . ILE A 1 555 ? -23.570 -57.209 -39.049 1.00 42.74  ? 818  ILE A CG2 1 
ATOM   4023 C  CD1 . ILE A 1 555 ? -21.408 -58.103 -37.070 1.00 44.64  ? 818  ILE A CD1 1 
ATOM   4024 N  N   . GLN A 1 556 ? -24.930 -54.179 -37.906 1.00 44.93  ? 819  GLN A N   1 
ATOM   4025 C  CA  . GLN A 1 556 ? -25.939 -53.422 -38.696 1.00 45.66  ? 819  GLN A CA  1 
ATOM   4026 C  C   . GLN A 1 556 ? -25.506 -51.954 -38.832 1.00 39.81  ? 819  GLN A C   1 
ATOM   4027 O  O   . GLN A 1 556 ? -25.411 -51.468 -39.950 1.00 40.32  ? 819  GLN A O   1 
ATOM   4028 C  CB  . GLN A 1 556 ? -27.305 -53.601 -38.030 1.00 50.17  ? 819  GLN A CB  1 
ATOM   4029 C  CG  . GLN A 1 556 ? -28.492 -53.269 -38.921 1.00 63.11  ? 819  GLN A CG  1 
ATOM   4030 C  CD  . GLN A 1 556 ? -29.728 -53.005 -38.088 1.00 70.70  ? 819  GLN A CD  1 
ATOM   4031 O  OE1 . GLN A 1 556 ? -30.346 -51.944 -38.169 1.00 78.11  ? 819  GLN A OE1 1 
ATOM   4032 N  NE2 . GLN A 1 556 ? -30.061 -53.944 -37.214 1.00 70.70  ? 819  GLN A NE2 1 
ATOM   4033 N  N   . GLU A 1 557 ? -25.243 -51.271 -37.725 1.00 37.25  ? 820  GLU A N   1 
ATOM   4034 C  CA  . GLU A 1 557 ? -24.988 -49.812 -37.704 1.00 37.54  ? 820  GLU A CA  1 
ATOM   4035 C  C   . GLU A 1 557 ? -23.485 -49.473 -37.756 1.00 40.70  ? 820  GLU A C   1 
ATOM   4036 O  O   . GLU A 1 557 ? -23.153 -48.286 -37.590 1.00 42.48  ? 820  GLU A O   1 
ATOM   4037 C  CB  . GLU A 1 557 ? -25.597 -49.232 -36.435 1.00 44.76  ? 820  GLU A CB  1 
ATOM   4038 C  CG  . GLU A 1 557 ? -27.105 -49.376 -36.368 1.00 51.76  ? 820  GLU A CG  1 
ATOM   4039 C  CD  . GLU A 1 557 ? -27.709 -48.619 -35.194 1.00 64.03  ? 820  GLU A CD  1 
ATOM   4040 O  OE1 . GLU A 1 557 ? -26.991 -48.444 -34.157 1.00 71.81  ? 820  GLU A OE1 1 
ATOM   4041 O  OE2 . GLU A 1 557 ? -28.896 -48.201 -35.308 1.00 79.99  ? 820  GLU A OE2 1 
ATOM   4042 N  N   . ASN A 1 558 ? -22.613 -50.457 -37.990 1.00 40.67  ? 821  ASN A N   1 
ATOM   4043 C  CA  . ASN A 1 558 ? -21.134 -50.321 -37.962 1.00 35.96  ? 821  ASN A CA  1 
ATOM   4044 C  C   . ASN A 1 558 ? -20.675 -49.922 -39.358 1.00 34.72  ? 821  ASN A C   1 
ATOM   4045 O  O   . ASN A 1 558 ? -20.600 -50.748 -40.249 1.00 37.11  ? 821  ASN A O   1 
ATOM   4046 C  CB  . ASN A 1 558 ? -20.497 -51.647 -37.544 1.00 33.35  ? 821  ASN A CB  1 
ATOM   4047 C  CG  . ASN A 1 558 ? -18.984 -51.613 -37.421 1.00 33.82  ? 821  ASN A CG  1 
ATOM   4048 O  OD1 . ASN A 1 558 ? -18.352 -50.705 -37.941 1.00 31.85  ? 821  ASN A OD1 1 
ATOM   4049 N  ND2 . ASN A 1 558 ? -18.396 -52.634 -36.794 1.00 30.30  ? 821  ASN A ND2 1 
ATOM   4050 N  N   . PRO A 1 559 ? -20.337 -48.661 -39.638 1.00 36.69  ? 822  PRO A N   1 
ATOM   4051 C  CA  . PRO A 1 559 ? -19.926 -48.315 -40.992 1.00 39.12  ? 822  PRO A CA  1 
ATOM   4052 C  C   . PRO A 1 559 ? -18.613 -48.949 -41.452 1.00 41.26  ? 822  PRO A C   1 
ATOM   4053 O  O   . PRO A 1 559 ? -18.324 -48.816 -42.611 1.00 42.97  ? 822  PRO A O   1 
ATOM   4054 C  CB  . PRO A 1 559 ? -19.817 -46.792 -40.960 1.00 40.76  ? 822  PRO A CB  1 
ATOM   4055 C  CG  . PRO A 1 559 ? -19.610 -46.484 -39.501 1.00 42.13  ? 822  PRO A CG  1 
ATOM   4056 C  CD  . PRO A 1 559 ? -20.464 -47.492 -38.768 1.00 37.24  ? 822  PRO A CD  1 
ATOM   4057 N  N   . TRP A 1 560 ? -17.872 -49.635 -40.580 1.00 39.13  ? 823  TRP A N   1 
ATOM   4058 C  CA  . TRP A 1 560 ? -16.605 -50.310 -40.981 1.00 40.70  ? 823  TRP A CA  1 
ATOM   4059 C  C   . TRP A 1 560 ? -16.831 -51.775 -41.391 1.00 40.25  ? 823  TRP A C   1 
ATOM   4060 O  O   . TRP A 1 560 ? -15.883 -52.376 -41.872 1.00 42.55  ? 823  TRP A O   1 
ATOM   4061 C  CB  . TRP A 1 560 ? -15.601 -50.170 -39.839 1.00 41.62  ? 823  TRP A CB  1 
ATOM   4062 C  CG  . TRP A 1 560 ? -15.129 -48.760 -39.708 1.00 37.31  ? 823  TRP A CG  1 
ATOM   4063 C  CD1 . TRP A 1 560 ? -14.192 -48.160 -40.485 1.00 37.49  ? 823  TRP A CD1 1 
ATOM   4064 C  CD2 . TRP A 1 560 ? -15.599 -47.752 -38.798 1.00 37.16  ? 823  TRP A CD2 1 
ATOM   4065 N  NE1 . TRP A 1 560 ? -14.019 -46.865 -40.092 1.00 41.28  ? 823  TRP A NE1 1 
ATOM   4066 C  CE2 . TRP A 1 560 ? -14.861 -46.584 -39.056 1.00 38.71  ? 823  TRP A CE2 1 
ATOM   4067 C  CE3 . TRP A 1 560 ? -16.495 -47.740 -37.737 1.00 36.15  ? 823  TRP A CE3 1 
ATOM   4068 C  CZ2 . TRP A 1 560 ? -15.016 -45.411 -38.328 1.00 36.59  ? 823  TRP A CZ2 1 
ATOM   4069 C  CZ3 . TRP A 1 560 ? -16.695 -46.563 -37.060 1.00 36.83  ? 823  TRP A CZ3 1 
ATOM   4070 C  CH2 . TRP A 1 560 ? -15.958 -45.417 -37.337 1.00 36.31  ? 823  TRP A CH2 1 
ATOM   4071 N  N   . MET A 1 561 ? -18.066 -52.278 -41.284 1.00 42.61  ? 824  MET A N   1 
ATOM   4072 C  CA  . MET A 1 561 ? -18.474 -53.692 -41.521 1.00 43.28  ? 824  MET A CA  1 
ATOM   4073 C  C   . MET A 1 561 ? -19.274 -53.724 -42.834 1.00 43.34  ? 824  MET A C   1 
ATOM   4074 O  O   . MET A 1 561 ? -20.419 -53.217 -42.864 1.00 41.76  ? 824  MET A O   1 
ATOM   4075 C  CB  . MET A 1 561 ? -19.313 -54.142 -40.314 1.00 43.70  ? 824  MET A CB  1 
ATOM   4076 C  CG  . MET A 1 561 ? -19.668 -55.609 -40.217 1.00 49.22  ? 824  MET A CG  1 
ATOM   4077 S  SD  . MET A 1 561 ? -18.251 -56.547 -39.799 1.00 67.62  ? 824  MET A SD  1 
ATOM   4078 C  CE  . MET A 1 561 ? -18.102 -56.273 -38.035 1.00 62.93  ? 824  MET A CE  1 
ATOM   4079 N  N   . GLU A 1 562 ? -18.683 -54.205 -43.926 1.00 46.78  ? 825  GLU A N   1 
ATOM   4080 C  CA  . GLU A 1 562 ? -19.396 -54.226 -45.231 1.00 53.26  ? 825  GLU A CA  1 
ATOM   4081 C  C   . GLU A 1 562 ? -20.464 -55.329 -45.213 1.00 51.42  ? 825  GLU A C   1 
ATOM   4082 O  O   . GLU A 1 562 ? -21.591 -55.018 -45.551 1.00 49.04  ? 825  GLU A O   1 
ATOM   4083 C  CB  . GLU A 1 562 ? -18.485 -54.424 -46.436 1.00 52.78  ? 825  GLU A CB  1 
ATOM   4084 C  CG  . GLU A 1 562 ? -19.060 -53.725 -47.646 1.00 69.67  ? 825  GLU A CG  1 
ATOM   4085 C  CD  . GLU A 1 562 ? -18.506 -54.128 -48.999 1.00 88.32  ? 825  GLU A CD  1 
ATOM   4086 O  OE1 . GLU A 1 562 ? -19.303 -54.119 -49.974 1.00 95.09  ? 825  GLU A OE1 1 
ATOM   4087 O  OE2 . GLU A 1 562 ? -17.280 -54.417 -49.085 1.00 97.59  ? 825  GLU A OE2 1 
ATOM   4088 N  N   . ASP A 1 563 ? -20.111 -56.548 -44.809 1.00 48.45  ? 826  ASP A N   1 
ATOM   4089 C  CA  . ASP A 1 563 ? -21.019 -57.718 -44.737 1.00 46.44  ? 826  ASP A CA  1 
ATOM   4090 C  C   . ASP A 1 563 ? -21.951 -57.595 -43.533 1.00 49.16  ? 826  ASP A C   1 
ATOM   4091 O  O   . ASP A 1 563 ? -21.434 -57.656 -42.416 1.00 44.47  ? 826  ASP A O   1 
ATOM   4092 C  CB  . ASP A 1 563 ? -20.190 -58.987 -44.627 1.00 47.55  ? 826  ASP A CB  1 
ATOM   4093 C  CG  . ASP A 1 563 ? -21.033 -60.234 -44.431 1.00 52.70  ? 826  ASP A CG  1 
ATOM   4094 O  OD1 . ASP A 1 563 ? -22.289 -60.108 -44.310 1.00 49.08  ? 826  ASP A OD1 1 
ATOM   4095 O  OD2 . ASP A 1 563 ? -20.420 -61.311 -44.348 1.00 51.00  ? 826  ASP A OD2 1 
ATOM   4096 N  N   . LYS A 1 564 ? -23.279 -57.535 -43.754 1.00 49.85  ? 827  LYS A N   1 
ATOM   4097 C  CA  . LYS A 1 564 ? -24.301 -57.267 -42.704 1.00 44.83  ? 827  LYS A CA  1 
ATOM   4098 C  C   . LYS A 1 564 ? -24.970 -58.569 -42.225 1.00 43.00  ? 827  LYS A C   1 
ATOM   4099 O  O   . LYS A 1 564 ? -26.035 -58.501 -41.563 1.00 40.34  ? 827  LYS A O   1 
ATOM   4100 C  CB  . LYS A 1 564 ? -25.341 -56.256 -43.207 1.00 49.13  ? 827  LYS A CB  1 
ATOM   4101 C  CG  . LYS A 1 564 ? -24.791 -54.897 -43.605 1.00 45.31  ? 827  LYS A CG  1 
ATOM   4102 C  CD  . LYS A 1 564 ? -23.953 -54.251 -42.554 1.00 43.13  ? 827  LYS A CD  1 
ATOM   4103 C  CE  . LYS A 1 564 ? -23.686 -52.797 -42.859 1.00 43.54  ? 827  LYS A CE  1 
ATOM   4104 N  NZ  . LYS A 1 564 ? -22.971 -52.115 -41.754 1.00 46.78  ? 827  LYS A NZ  1 
ATOM   4105 N  N   . THR A 1 565 ? -24.356 -59.721 -42.465 1.00 41.19  ? 828  THR A N   1 
ATOM   4106 C  CA  . THR A 1 565 ? -24.896 -61.029 -42.004 1.00 42.55  ? 828  THR A CA  1 
ATOM   4107 C  C   . THR A 1 565 ? -24.981 -61.009 -40.489 1.00 43.88  ? 828  THR A C   1 
ATOM   4108 O  O   . THR A 1 565 ? -23.958 -60.843 -39.838 1.00 43.34  ? 828  THR A O   1 
ATOM   4109 C  CB  . THR A 1 565 ? -24.008 -62.179 -42.475 1.00 45.29  ? 828  THR A CB  1 
ATOM   4110 O  OG1 . THR A 1 565 ? -23.907 -61.958 -43.879 1.00 48.49  ? 828  THR A OG1 1 
ATOM   4111 C  CG2 . THR A 1 565 ? -24.561 -63.545 -42.151 1.00 48.00  ? 828  THR A CG2 1 
ATOM   4112 N  N   . PRO A 1 566 ? -26.175 -61.169 -39.878 1.00 45.58  ? 829  PRO A N   1 
ATOM   4113 C  CA  . PRO A 1 566 ? -26.293 -61.102 -38.422 1.00 45.41  ? 829  PRO A CA  1 
ATOM   4114 C  C   . PRO A 1 566 ? -25.566 -62.292 -37.798 1.00 47.06  ? 829  PRO A C   1 
ATOM   4115 O  O   . PRO A 1 566 ? -25.292 -63.272 -38.500 1.00 43.23  ? 829  PRO A O   1 
ATOM   4116 C  CB  . PRO A 1 566 ? -27.800 -61.160 -38.130 1.00 46.93  ? 829  PRO A CB  1 
ATOM   4117 C  CG  . PRO A 1 566 ? -28.456 -60.925 -39.485 1.00 45.58  ? 829  PRO A CG  1 
ATOM   4118 C  CD  . PRO A 1 566 ? -27.465 -61.433 -40.521 1.00 44.09  ? 829  PRO A CD  1 
ATOM   4119 N  N   . VAL A 1 567 ? -25.265 -62.176 -36.509 1.00 45.98  ? 830  VAL A N   1 
ATOM   4120 C  CA  . VAL A 1 567 ? -24.682 -63.288 -35.704 1.00 51.14  ? 830  VAL A CA  1 
ATOM   4121 C  C   . VAL A 1 567 ? -25.850 -63.979 -34.959 1.00 47.84  ? 830  VAL A C   1 
ATOM   4122 O  O   . VAL A 1 567 ? -26.737 -63.266 -34.442 1.00 51.35  ? 830  VAL A O   1 
ATOM   4123 C  CB  . VAL A 1 567 ? -23.565 -62.722 -34.796 1.00 51.99  ? 830  VAL A CB  1 
ATOM   4124 C  CG1 . VAL A 1 567 ? -23.427 -63.478 -33.503 1.00 54.58  ? 830  VAL A CG1 1 
ATOM   4125 C  CG2 . VAL A 1 567 ? -22.219 -62.643 -35.503 1.00 50.54  ? 830  VAL A CG2 1 
ATOM   4126 N  N   . GLU A 1 568 ? -25.843 -65.314 -34.907 1.00 48.03  ? 831  GLU A N   1 
ATOM   4127 C  CA  . GLU A 1 568 ? -26.984 -66.187 -34.487 1.00 53.23  ? 831  GLU A CA  1 
ATOM   4128 C  C   . GLU A 1 568 ? -26.828 -66.635 -33.035 1.00 52.23  ? 831  GLU A C   1 
ATOM   4129 O  O   . GLU A 1 568 ? -27.859 -66.978 -32.424 1.00 51.56  ? 831  GLU A O   1 
ATOM   4130 C  CB  . GLU A 1 568 ? -27.050 -67.422 -35.393 1.00 58.92  ? 831  GLU A CB  1 
ATOM   4131 C  CG  . GLU A 1 568 ? -27.360 -67.088 -36.849 1.00 61.74  ? 831  GLU A CG  1 
ATOM   4132 C  CD  . GLU A 1 568 ? -28.692 -66.375 -37.020 1.00 67.19  ? 831  GLU A CD  1 
ATOM   4133 O  OE1 . GLU A 1 568 ? -29.586 -66.594 -36.191 1.00 63.38  ? 831  GLU A OE1 1 
ATOM   4134 O  OE2 . GLU A 1 568 ? -28.829 -65.592 -37.966 1.00 71.82  ? 831  GLU A OE2 1 
ATOM   4135 N  N   . SER A 1 569 ? -25.597 -66.669 -32.503 1.00 42.78  ? 832  SER A N   1 
ATOM   4136 C  CA  . SER A 1 569 ? -25.339 -66.975 -31.073 1.00 41.32  ? 832  SER A CA  1 
ATOM   4137 C  C   . SER A 1 569 ? -24.075 -66.270 -30.559 1.00 43.12  ? 832  SER A C   1 
ATOM   4138 O  O   . SER A 1 569 ? -23.203 -65.810 -31.349 1.00 41.04  ? 832  SER A O   1 
ATOM   4139 C  CB  . SER A 1 569 ? -25.194 -68.445 -30.891 1.00 41.47  ? 832  SER A CB  1 
ATOM   4140 O  OG  . SER A 1 569 ? -24.009 -68.857 -31.548 1.00 44.14  ? 832  SER A OG  1 
ATOM   4141 N  N   . TRP A 1 570 ? -23.935 -66.240 -29.255 1.00 37.83  ? 833  TRP A N   1 
ATOM   4142 C  CA  . TRP A 1 570 ? -22.735 -65.660 -28.613 1.00 43.81  ? 833  TRP A CA  1 
ATOM   4143 C  C   . TRP A 1 570 ? -21.469 -66.455 -29.005 1.00 42.06  ? 833  TRP A C   1 
ATOM   4144 O  O   . TRP A 1 570 ? -20.363 -65.871 -29.092 1.00 39.49  ? 833  TRP A O   1 
ATOM   4145 C  CB  . TRP A 1 570 ? -23.016 -65.603 -27.119 1.00 39.56  ? 833  TRP A CB  1 
ATOM   4146 C  CG  . TRP A 1 570 ? -23.903 -64.457 -26.771 1.00 41.38  ? 833  TRP A CG  1 
ATOM   4147 C  CD1 . TRP A 1 570 ? -25.241 -64.502 -26.512 1.00 41.39  ? 833  TRP A CD1 1 
ATOM   4148 C  CD2 . TRP A 1 570 ? -23.503 -63.079 -26.638 1.00 41.14  ? 833  TRP A CD2 1 
ATOM   4149 N  NE1 . TRP A 1 570 ? -25.706 -63.247 -26.223 1.00 42.22  ? 833  TRP A NE1 1 
ATOM   4150 C  CE2 . TRP A 1 570 ? -24.659 -62.354 -26.274 1.00 39.12  ? 833  TRP A CE2 1 
ATOM   4151 C  CE3 . TRP A 1 570 ? -22.282 -62.391 -26.746 1.00 42.65  ? 833  TRP A CE3 1 
ATOM   4152 C  CZ2 . TRP A 1 570 ? -24.620 -60.980 -26.015 1.00 39.25  ? 833  TRP A CZ2 1 
ATOM   4153 C  CZ3 . TRP A 1 570 ? -22.252 -61.033 -26.500 1.00 41.80  ? 833  TRP A CZ3 1 
ATOM   4154 C  CH2 . TRP A 1 570 ? -23.409 -60.331 -26.142 1.00 40.23  ? 833  TRP A CH2 1 
ATOM   4155 N  N   . GLU A 1 571 ? -21.590 -67.725 -29.338 1.00 43.14  ? 834  GLU A N   1 
ATOM   4156 C  CA  . GLU A 1 571 ? -20.382 -68.535 -29.635 1.00 49.84  ? 834  GLU A CA  1 
ATOM   4157 C  C   . GLU A 1 571 ? -19.749 -68.113 -30.964 1.00 44.63  ? 834  GLU A C   1 
ATOM   4158 O  O   . GLU A 1 571 ? -18.578 -68.421 -31.152 1.00 46.56  ? 834  GLU A O   1 
ATOM   4159 C  CB  . GLU A 1 571 ? -20.732 -70.018 -29.560 1.00 62.14  ? 834  GLU A CB  1 
ATOM   4160 C  CG  . GLU A 1 571 ? -21.083 -70.453 -28.142 1.00 73.05  ? 834  GLU A CG  1 
ATOM   4161 C  CD  . GLU A 1 571 ? -21.671 -71.853 -28.036 1.00 91.44  ? 834  GLU A CD  1 
ATOM   4162 O  OE1 . GLU A 1 571 ? -21.408 -72.674 -28.960 1.00 92.76  ? 834  GLU A OE1 1 
ATOM   4163 O  OE2 . GLU A 1 571 ? -22.399 -72.136 -27.033 1.00 108.49 ? 834  GLU A OE2 1 
ATOM   4164 N  N   . GLU A 1 572 ? -20.477 -67.447 -31.856 1.00 40.20  ? 835  GLU A N   1 
ATOM   4165 C  CA  . GLU A 1 572 ? -19.893 -66.837 -33.089 1.00 45.41  ? 835  GLU A CA  1 
ATOM   4166 C  C   . GLU A 1 572 ? -18.979 -65.646 -32.723 1.00 40.31  ? 835  GLU A C   1 
ATOM   4167 O  O   . GLU A 1 572 ? -18.240 -65.144 -33.605 1.00 41.02  ? 835  GLU A O   1 
ATOM   4168 C  CB  . GLU A 1 572 ? -20.983 -66.284 -34.019 1.00 46.11  ? 835  GLU A CB  1 
ATOM   4169 C  CG  . GLU A 1 572 ? -21.378 -67.165 -35.189 1.00 59.20  ? 835  GLU A CG  1 
ATOM   4170 C  CD  . GLU A 1 572 ? -22.545 -66.605 -36.011 1.00 58.43  ? 835  GLU A CD  1 
ATOM   4171 O  OE1 . GLU A 1 572 ? -22.307 -65.899 -37.025 1.00 65.77  ? 835  GLU A OE1 1 
ATOM   4172 O  OE2 . GLU A 1 572 ? -23.695 -66.870 -35.644 1.00 59.41  ? 835  GLU A OE2 1 
ATOM   4173 N  N   . ILE A 1 573 ? -19.156 -65.080 -31.539 1.00 39.26  ? 836  ILE A N   1 
ATOM   4174 C  CA  . ILE A 1 573 ? -18.508 -63.800 -31.132 1.00 35.95  ? 836  ILE A CA  1 
ATOM   4175 C  C   . ILE A 1 573 ? -17.204 -64.153 -30.408 1.00 34.46  ? 836  ILE A C   1 
ATOM   4176 O  O   . ILE A 1 573 ? -17.191 -64.806 -29.338 1.00 35.09  ? 836  ILE A O   1 
ATOM   4177 C  CB  . ILE A 1 573 ? -19.466 -62.953 -30.284 1.00 37.20  ? 836  ILE A CB  1 
ATOM   4178 C  CG1 . ILE A 1 573 ? -20.683 -62.508 -31.088 1.00 36.77  ? 836  ILE A CG1 1 
ATOM   4179 C  CG2 . ILE A 1 573 ? -18.709 -61.770 -29.682 1.00 40.04  ? 836  ILE A CG2 1 
ATOM   4180 C  CD1 . ILE A 1 573 ? -21.805 -61.937 -30.240 1.00 37.39  ? 836  ILE A CD1 1 
ATOM   4181 N  N   . PRO A 1 574 ? -16.059 -63.705 -30.960 1.00 31.60  ? 837  PRO A N   1 
ATOM   4182 C  CA  . PRO A 1 574 ? -14.753 -64.127 -30.453 1.00 33.28  ? 837  PRO A CA  1 
ATOM   4183 C  C   . PRO A 1 574 ? -14.254 -63.445 -29.175 1.00 30.64  ? 837  PRO A C   1 
ATOM   4184 O  O   . PRO A 1 574 ? -14.789 -62.450 -28.759 1.00 31.39  ? 837  PRO A O   1 
ATOM   4185 C  CB  . PRO A 1 574 ? -13.842 -63.765 -31.626 1.00 34.27  ? 837  PRO A CB  1 
ATOM   4186 C  CG  . PRO A 1 574 ? -14.459 -62.495 -32.159 1.00 37.13  ? 837  PRO A CG  1 
ATOM   4187 C  CD  . PRO A 1 574 ? -15.956 -62.684 -32.011 1.00 34.98  ? 837  PRO A CD  1 
ATOM   4188 N  N   . TYR A 1 575 ? -13.146 -63.961 -28.635 0.44 32.28  ? 838  TYR A N   1 
ATOM   4189 C  CA  . TYR A 1 575 ? -12.374 -63.360 -27.517 0.44 31.60  ? 838  TYR A CA  1 
ATOM   4190 C  C   . TYR A 1 575 ? -10.984 -62.922 -28.005 0.44 31.22  ? 838  TYR A C   1 
ATOM   4191 O  O   . TYR A 1 575 ? -10.538 -63.365 -29.072 0.44 30.31  ? 838  TYR A O   1 
ATOM   4192 C  CB  . TYR A 1 575 ? -12.210 -64.365 -26.379 0.44 31.40  ? 838  TYR A CB  1 
ATOM   4193 C  CG  . TYR A 1 575 ? -13.485 -64.956 -25.842 0.44 31.28  ? 838  TYR A CG  1 
ATOM   4194 C  CD1 . TYR A 1 575 ? -14.105 -64.425 -24.723 0.44 31.68  ? 838  TYR A CD1 1 
ATOM   4195 C  CD2 . TYR A 1 575 ? -14.054 -66.073 -26.430 0.44 31.31  ? 838  TYR A CD2 1 
ATOM   4196 C  CE1 . TYR A 1 575 ? -15.272 -64.975 -24.214 0.44 31.82  ? 838  TYR A CE1 1 
ATOM   4197 C  CE2 . TYR A 1 575 ? -15.209 -66.645 -25.927 0.44 31.46  ? 838  TYR A CE2 1 
ATOM   4198 C  CZ  . TYR A 1 575 ? -15.821 -66.093 -24.817 0.44 31.65  ? 838  TYR A CZ  1 
ATOM   4199 O  OH  . TYR A 1 575 ? -16.969 -66.644 -24.338 0.44 31.16  ? 838  TYR A OH  1 
ATOM   4200 N  N   . LEU A 1 576 ? -10.273 -62.233 -27.118 0.44 28.93  ? 839  LEU A N   1 
ATOM   4201 C  CA  . LEU A 1 576 ? -8.857  -61.935 -27.397 0.44 29.37  ? 839  LEU A CA  1 
ATOM   4202 C  C   . LEU A 1 576 ? -8.129  -63.261 -27.196 0.44 29.39  ? 839  LEU A C   1 
ATOM   4203 O  O   . LEU A 1 576 ? -8.745  -64.178 -26.627 0.44 30.22  ? 839  LEU A O   1 
ATOM   4204 C  CB  . LEU A 1 576 ? -8.375  -60.920 -26.359 0.44 28.19  ? 839  LEU A CB  1 
ATOM   4205 C  CG  . LEU A 1 576 ? -9.174  -59.623 -26.261 0.44 28.09  ? 839  LEU A CG  1 
ATOM   4206 C  CD1 . LEU A 1 576 ? -8.648  -58.761 -25.125 0.44 27.57  ? 839  LEU A CD1 1 
ATOM   4207 C  CD2 . LEU A 1 576 ? -9.128  -58.859 -27.573 0.44 28.22  ? 839  LEU A CD2 1 
ATOM   4208 N  N   . GLY A 1 577 ? -6.876  -63.368 -27.629 0.44 29.40  ? 840  GLY A N   1 
ATOM   4209 C  CA  . GLY A 1 577 ? -6.109  -64.590 -27.327 0.44 28.01  ? 840  GLY A CA  1 
ATOM   4210 C  C   . GLY A 1 577 ? -6.013  -64.782 -25.823 0.44 26.78  ? 840  GLY A C   1 
ATOM   4211 O  O   . GLY A 1 577 ? -6.097  -63.780 -25.097 0.44 25.35  ? 840  GLY A O   1 
ATOM   4212 N  N   . LYS A 1 578 ? -5.857  -66.025 -25.371 0.44 26.99  ? 841  LYS A N   1 
ATOM   4213 C  CA  . LYS A 1 578 ? -5.801  -66.318 -23.915 0.44 28.38  ? 841  LYS A CA  1 
ATOM   4214 C  C   . LYS A 1 578 ? -4.668  -65.517 -23.262 0.44 27.70  ? 841  LYS A C   1 
ATOM   4215 O  O   . LYS A 1 578 ? -4.890  -64.987 -22.167 0.44 27.63  ? 841  LYS A O   1 
ATOM   4216 C  CB  . LYS A 1 578 ? -5.619  -67.821 -23.695 0.44 29.69  ? 841  LYS A CB  1 
ATOM   4217 C  CG  . LYS A 1 578 ? -6.781  -68.690 -24.157 0.44 30.47  ? 841  LYS A CG  1 
ATOM   4218 C  CD  . LYS A 1 578 ? -6.569  -70.169 -23.914 0.44 31.35  ? 841  LYS A CD  1 
ATOM   4219 C  CE  . LYS A 1 578 ? -5.544  -70.790 -24.837 0.44 31.23  ? 841  LYS A CE  1 
ATOM   4220 N  NZ  . LYS A 1 578 ? -5.998  -70.779 -26.247 0.44 31.52  ? 841  LYS A NZ  1 
ATOM   4221 N  N   . ARG A 1 579 ? -3.506  -65.439 -23.914 0.44 28.14  ? 842  ARG A N   1 
ATOM   4222 C  CA  . ARG A 1 579 ? -2.339  -64.712 -23.339 0.44 28.60  ? 842  ARG A CA  1 
ATOM   4223 C  C   . ARG A 1 579 ? -2.637  -63.210 -23.324 0.44 28.05  ? 842  ARG A C   1 
ATOM   4224 O  O   . ARG A 1 579 ? -2.356  -62.572 -22.298 0.44 29.41  ? 842  ARG A O   1 
ATOM   4225 C  CB  . ARG A 1 579 ? -1.057  -65.037 -24.110 0.44 28.12  ? 842  ARG A CB  1 
ATOM   4226 C  CG  . ARG A 1 579 ? 0.207   -64.503 -23.454 0.44 28.55  ? 842  ARG A CG  1 
ATOM   4227 C  CD  . ARG A 1 579 ? 1.464   -65.081 -24.071 0.44 28.99  ? 842  ARG A CD  1 
ATOM   4228 N  NE  . ARG A 1 579 ? 1.385   -66.531 -24.162 0.44 28.23  ? 842  ARG A NE  1 
ATOM   4229 C  CZ  . ARG A 1 579 ? 1.636   -67.359 -23.157 0.44 27.25  ? 842  ARG A CZ  1 
ATOM   4230 N  NH1 . ARG A 1 579 ? 1.531   -68.664 -23.335 0.44 26.84  ? 842  ARG A NH1 1 
ATOM   4231 N  NH2 . ARG A 1 579 ? 1.982   -66.880 -21.977 0.44 27.85  ? 842  ARG A NH2 1 
ATOM   4232 N  N   . GLU A 1 580 ? -3.186  -62.676 -24.416 0.44 27.72  ? 843  GLU A N   1 
ATOM   4233 C  CA  . GLU A 1 580 ? -3.592  -61.247 -24.448 0.44 28.73  ? 843  GLU A CA  1 
ATOM   4234 C  C   . GLU A 1 580 ? -4.588  -60.987 -23.317 0.44 26.09  ? 843  GLU A C   1 
ATOM   4235 O  O   . GLU A 1 580 ? -4.497  -59.924 -22.689 0.44 26.30  ? 843  GLU A O   1 
ATOM   4236 C  CB  . GLU A 1 580 ? -4.260  -60.912 -25.780 0.44 31.39  ? 843  GLU A CB  1 
ATOM   4237 C  CG  . GLU A 1 580 ? -3.353  -61.057 -26.983 0.44 33.31  ? 843  GLU A CG  1 
ATOM   4238 C  CD  . GLU A 1 580 ? -4.048  -60.751 -28.297 0.44 36.72  ? 843  GLU A CD  1 
ATOM   4239 O  OE1 . GLU A 1 580 ? -5.174  -61.244 -28.497 0.44 38.38  ? 843  GLU A OE1 1 
ATOM   4240 O  OE2 . GLU A 1 580 ? -3.466  -60.009 -29.109 0.44 34.70  ? 843  GLU A OE2 1 
ATOM   4241 N  N   . ASP A 1 581 ? -5.495  -61.935 -23.076 1.00 25.64  ? 844  ASP A N   1 
ATOM   4242 C  CA  . ASP A 1 581 ? -6.546  -61.770 -22.025 1.00 26.54  ? 844  ASP A CA  1 
ATOM   4243 C  C   . ASP A 1 581 ? -5.868  -61.646 -20.678 1.00 27.38  ? 844  ASP A C   1 
ATOM   4244 O  O   . ASP A 1 581 ? -6.206  -60.724 -19.892 1.00 28.58  ? 844  ASP A O   1 
ATOM   4245 C  CB  . ASP A 1 581 ? -7.560  -62.905 -22.055 1.00 26.68  ? 844  ASP A CB  1 
ATOM   4246 C  CG  . ASP A 1 581 ? -8.996  -62.560 -21.682 1.00 27.85  ? 844  ASP A CG  1 
ATOM   4247 O  OD1 . ASP A 1 581 ? -9.230  -61.525 -20.938 1.00 26.23  ? 844  ASP A OD1 1 
ATOM   4248 O  OD2 . ASP A 1 581 ? -9.864  -63.407 -22.030 1.00 28.14  ? 844  ASP A OD2 1 
ATOM   4249 N  N   . GLN A 1 582 ? -4.887  -62.516 -20.429 0.44 29.73  ? 845  GLN A N   1 
ATOM   4250 C  CA  . GLN A 1 582 ? -4.072  -62.537 -19.183 0.44 30.61  ? 845  GLN A CA  1 
ATOM   4251 C  C   . GLN A 1 582 ? -3.279  -61.221 -19.082 0.44 29.00  ? 845  GLN A C   1 
ATOM   4252 O  O   . GLN A 1 582 ? -3.270  -60.599 -17.985 0.44 28.70  ? 845  GLN A O   1 
ATOM   4253 C  CB  . GLN A 1 582 ? -3.169  -63.781 -19.183 0.44 33.54  ? 845  GLN A CB  1 
ATOM   4254 C  CG  . GLN A 1 582 ? -2.882  -64.339 -17.795 0.44 34.87  ? 845  GLN A CG  1 
ATOM   4255 C  CD  . GLN A 1 582 ? -2.171  -65.672 -17.840 0.44 36.60  ? 845  GLN A CD  1 
ATOM   4256 O  OE1 . GLN A 1 582 ? -1.497  -66.004 -18.811 0.44 36.25  ? 845  GLN A OE1 1 
ATOM   4257 N  NE2 . GLN A 1 582 ? -2.321  -66.454 -16.782 0.44 36.76  ? 845  GLN A NE2 1 
ATOM   4258 N  N   . TRP A 1 583 ? -2.655  -60.796 -20.184 1.00 27.14  ? 846  TRP A N   1 
ATOM   4259 C  CA  . TRP A 1 583 ? -1.911  -59.498 -20.244 1.00 26.71  ? 846  TRP A CA  1 
ATOM   4260 C  C   . TRP A 1 583 ? -2.832  -58.336 -19.851 1.00 31.37  ? 846  TRP A C   1 
ATOM   4261 O  O   . TRP A 1 583 ? -2.343  -57.411 -19.185 1.00 27.23  ? 846  TRP A O   1 
ATOM   4262 C  CB  . TRP A 1 583 ? -1.336  -59.260 -21.630 1.00 26.29  ? 846  TRP A CB  1 
ATOM   4263 C  CG  . TRP A 1 583 ? -0.169  -60.136 -21.985 1.00 29.46  ? 846  TRP A CG  1 
ATOM   4264 C  CD1 . TRP A 1 583 ? 0.616   -60.863 -21.141 1.00 29.63  ? 846  TRP A CD1 1 
ATOM   4265 C  CD2 . TRP A 1 583 ? 0.341   -60.362 -23.306 1.00 29.49  ? 846  TRP A CD2 1 
ATOM   4266 N  NE1 . TRP A 1 583 ? 1.598   -61.503 -21.855 1.00 33.09  ? 846  TRP A NE1 1 
ATOM   4267 C  CE2 . TRP A 1 583 ? 1.444   -61.230 -23.187 1.00 30.98  ? 846  TRP A CE2 1 
ATOM   4268 C  CE3 . TRP A 1 583 ? -0.039  -59.931 -24.577 1.00 31.83  ? 846  TRP A CE3 1 
ATOM   4269 C  CZ2 . TRP A 1 583 ? 2.166   -61.686 -24.300 1.00 33.73  ? 846  TRP A CZ2 1 
ATOM   4270 C  CZ3 . TRP A 1 583 ? 0.681   -60.361 -25.675 1.00 34.11  ? 846  TRP A CZ3 1 
ATOM   4271 C  CH2 . TRP A 1 583 ? 1.782   -61.208 -25.536 1.00 35.75  ? 846  TRP A CH2 1 
ATOM   4272 N  N   . CYS A 1 584 ? -4.130  -58.369 -20.230 1.00 27.66  ? 847  CYS A N   1 
ATOM   4273 C  CA  . CYS A 1 584 ? -5.052  -57.262 -19.859 1.00 28.44  ? 847  CYS A CA  1 
ATOM   4274 C  C   . CYS A 1 584 ? -5.784  -57.534 -18.549 1.00 28.55  ? 847  CYS A C   1 
ATOM   4275 O  O   . CYS A 1 584 ? -6.839  -56.866 -18.310 1.00 30.31  ? 847  CYS A O   1 
ATOM   4276 C  CB  . CYS A 1 584 ? -5.956  -56.918 -21.019 1.00 29.38  ? 847  CYS A CB  1 
ATOM   4277 S  SG  . CYS A 1 584 ? -4.952  -56.244 -22.354 1.00 29.81  ? 847  CYS A SG  1 
ATOM   4278 N  N   . GLY A 1 585 ? -5.266  -58.474 -17.748 1.00 27.96  ? 848  GLY A N   1 
ATOM   4279 C  CA  . GLY A 1 585 ? -5.652  -58.676 -16.338 1.00 27.44  ? 848  GLY A CA  1 
ATOM   4280 C  C   . GLY A 1 585 ? -6.558  -59.864 -16.080 1.00 26.90  ? 848  GLY A C   1 
ATOM   4281 O  O   . GLY A 1 585 ? -6.998  -59.990 -14.913 1.00 30.74  ? 848  GLY A O   1 
ATOM   4282 N  N   . SER A 1 586 ? -6.856  -60.718 -17.074 1.00 24.75  ? 849  SER A N   1 
ATOM   4283 C  CA  . SER A 1 586 ? -7.710  -61.916 -16.847 1.00 26.99  ? 849  SER A CA  1 
ATOM   4284 C  C   . SER A 1 586 ? -7.112  -62.799 -15.745 1.00 31.02  ? 849  SER A C   1 
ATOM   4285 O  O   . SER A 1 586 ? -5.875  -62.889 -15.655 1.00 29.49  ? 849  SER A O   1 
ATOM   4286 C  CB  . SER A 1 586 ? -7.871  -62.727 -18.083 1.00 26.21  ? 849  SER A CB  1 
ATOM   4287 O  OG  . SER A 1 586 ? -8.707  -63.854 -17.820 1.00 25.29  ? 849  SER A OG  1 
ATOM   4288 N  N   . LEU A 1 587 ? -7.975  -63.519 -15.020 0.44 28.53  ? 850  LEU A N   1 
ATOM   4289 C  CA  . LEU A 1 587 ? -7.584  -64.517 -13.986 0.44 27.61  ? 850  LEU A CA  1 
ATOM   4290 C  C   . LEU A 1 587 ? -7.700  -65.944 -14.530 0.44 26.41  ? 850  LEU A C   1 
ATOM   4291 O  O   . LEU A 1 587 ? -7.622  -66.866 -13.716 0.44 27.74  ? 850  LEU A O   1 
ATOM   4292 C  CB  . LEU A 1 587 ? -8.474  -64.356 -12.749 0.44 28.53  ? 850  LEU A CB  1 
ATOM   4293 C  CG  . LEU A 1 587 ? -8.450  -62.995 -12.056 0.44 29.88  ? 850  LEU A CG  1 
ATOM   4294 C  CD1 . LEU A 1 587 ? -9.090  -63.096 -10.672 0.44 30.24  ? 850  LEU A CD1 1 
ATOM   4295 C  CD2 . LEU A 1 587 ? -7.028  -62.461 -11.944 0.44 30.76  ? 850  LEU A CD2 1 
ATOM   4296 N  N   . ILE A 1 588 ? -7.895  -66.152 -15.836 0.44 25.89  ? 851  ILE A N   1 
ATOM   4297 C  CA  . ILE A 1 588 ? -7.837  -67.527 -16.415 0.44 26.12  ? 851  ILE A CA  1 
ATOM   4298 C  C   . ILE A 1 588 ? -6.475  -68.129 -16.038 0.44 27.54  ? 851  ILE A C   1 
ATOM   4299 O  O   . ILE A 1 588 ? -5.470  -67.384 -16.046 0.44 27.55  ? 851  ILE A O   1 
ATOM   4300 C  CB  . ILE A 1 588 ? -8.071  -67.546 -17.939 0.44 24.97  ? 851  ILE A CB  1 
ATOM   4301 C  CG1 . ILE A 1 588 ? -7.097  -66.628 -18.683 0.44 24.81  ? 851  ILE A CG1 1 
ATOM   4302 C  CG2 . ILE A 1 588 ? -9.522  -67.223 -18.270 0.44 24.80  ? 851  ILE A CG2 1 
ATOM   4303 C  CD1 . ILE A 1 588 ? -7.213  -66.700 -20.186 0.44 24.24  ? 851  ILE A CD1 1 
ATOM   4304 N  N   . GLY A 1 589 ? -6.440  -69.422 -15.710 0.44 29.50  ? 852  GLY A N   1 
ATOM   4305 C  CA  . GLY A 1 589 ? -5.232  -70.099 -15.198 0.44 30.35  ? 852  GLY A CA  1 
ATOM   4306 C  C   . GLY A 1 589 ? -5.328  -70.302 -13.698 0.44 32.20  ? 852  GLY A C   1 
ATOM   4307 O  O   . GLY A 1 589 ? -5.120  -71.445 -13.260 0.44 32.37  ? 852  GLY A O   1 
ATOM   4308 N  N   . LEU A 1 590 ? -5.675  -69.249 -12.943 0.44 31.36  ? 853  LEU A N   1 
ATOM   4309 C  CA  . LEU A 1 590 ? -5.814  -69.318 -11.464 0.44 32.84  ? 853  LEU A CA  1 
ATOM   4310 C  C   . LEU A 1 590 ? -6.875  -70.367 -11.090 0.44 35.70  ? 853  LEU A C   1 
ATOM   4311 O  O   . LEU A 1 590 ? -7.851  -70.560 -11.862 0.44 35.88  ? 853  LEU A O   1 
ATOM   4312 C  CB  . LEU A 1 590 ? -6.183  -67.950 -10.877 0.44 32.28  ? 853  LEU A CB  1 
ATOM   4313 C  CG  . LEU A 1 590 ? -5.121  -66.847 -10.907 0.44 32.71  ? 853  LEU A CG  1 
ATOM   4314 C  CD1 . LEU A 1 590 ? -5.493  -65.734 -9.936  0.44 32.25  ? 853  LEU A CD1 1 
ATOM   4315 C  CD2 . LEU A 1 590 ? -3.723  -67.365 -10.586 0.44 32.89  ? 853  LEU A CD2 1 
ATOM   4316 N  N   . THR A 1 591 ? -6.675  -71.019 -9.938  0.44 37.49  ? 854  THR A N   1 
ATOM   4317 C  CA  . THR A 1 591 ? -7.586  -72.039 -9.350  0.44 37.98  ? 854  THR A CA  1 
ATOM   4318 C  C   . THR A 1 591 ? -8.779  -71.332 -8.695  0.44 36.12  ? 854  THR A C   1 
ATOM   4319 O  O   . THR A 1 591 ? -9.890  -71.881 -8.778  0.44 37.88  ? 854  THR A O   1 
ATOM   4320 C  CB  . THR A 1 591 ? -6.826  -72.978 -8.400  0.44 36.58  ? 854  THR A CB  1 
ATOM   4321 O  OG1 . THR A 1 591 ? -6.082  -73.870 -9.224  0.44 37.51  ? 854  THR A OG1 1 
ATOM   4322 C  CG2 . THR A 1 591 ? -7.721  -73.797 -7.499  0.44 38.24  ? 854  THR A CG2 1 
ATOM   4323 N  N   . SER A 1 592 ? -8.582  -70.164 -8.079  1.00 35.39  ? 855  SER A N   1 
ATOM   4324 C  CA  . SER A 1 592 ? -9.729  -69.318 -7.643  1.00 37.30  ? 855  SER A CA  1 
ATOM   4325 C  C   . SER A 1 592 ? -10.729 -69.079 -8.799  1.00 37.81  ? 855  SER A C   1 
ATOM   4326 O  O   . SER A 1 592 ? -11.938 -69.217 -8.562  1.00 38.60  ? 855  SER A O   1 
ATOM   4327 C  CB  . SER A 1 592 ? -9.293  -68.032 -7.026  1.00 36.96  ? 855  SER A CB  1 
ATOM   4328 O  OG  . SER A 1 592 ? -8.651  -67.176 -7.971  1.00 39.47  ? 855  SER A OG  1 
ATOM   4329 N  N   . ARG A 1 593 ? -10.248 -68.749 -10.000 1.00 35.57  ? 856  ARG A N   1 
ATOM   4330 C  CA  . ARG A 1 593 ? -11.082 -68.413 -11.168 1.00 35.01  ? 856  ARG A CA  1 
ATOM   4331 C  C   . ARG A 1 593 ? -11.770 -69.695 -11.653 1.00 40.01  ? 856  ARG A C   1 
ATOM   4332 O  O   . ARG A 1 593 ? -12.983 -69.623 -11.909 1.00 33.15  ? 856  ARG A O   1 
ATOM   4333 C  CB  . ARG A 1 593 ? -10.233 -67.711 -12.232 1.00 33.03  ? 856  ARG A CB  1 
ATOM   4334 C  CG  . ARG A 1 593 ? -11.009 -67.068 -13.370 1.00 34.45  ? 856  ARG A CG  1 
ATOM   4335 C  CD  . ARG A 1 593 ? -11.474 -68.047 -14.433 1.00 35.64  ? 856  ARG A CD  1 
ATOM   4336 N  NE  . ARG A 1 593 ? -12.018 -67.307 -15.544 1.00 35.95  ? 856  ARG A NE  1 
ATOM   4337 C  CZ  . ARG A 1 593 ? -12.770 -67.807 -16.532 1.00 34.12  ? 856  ARG A CZ  1 
ATOM   4338 N  NH1 . ARG A 1 593 ? -13.058 -69.087 -16.574 1.00 34.69  ? 856  ARG A NH1 1 
ATOM   4339 N  NH2 . ARG A 1 593 ? -13.217 -67.020 -17.496 1.00 31.46  ? 856  ARG A NH2 1 
ATOM   4340 N  N   . ALA A 1 594 ? -11.051 -70.825 -11.736 1.00 36.08  ? 857  ALA A N   1 
ATOM   4341 C  CA  . ALA A 1 594 ? -11.592 -72.145 -12.154 1.00 39.02  ? 857  ALA A CA  1 
ATOM   4342 C  C   . ALA A 1 594 ? -12.746 -72.574 -11.223 1.00 39.53  ? 857  ALA A C   1 
ATOM   4343 O  O   . ALA A 1 594 ? -13.754 -73.096 -11.711 1.00 31.44  ? 857  ALA A O   1 
ATOM   4344 C  CB  . ALA A 1 594 ? -10.508 -73.191 -12.139 1.00 41.13  ? 857  ALA A CB  1 
ATOM   4345 N  N   . THR A 1 595 ? -12.609 -72.359 -9.921  1.00 33.58  ? 858  THR A N   1 
ATOM   4346 C  CA  . THR A 1 595 ? -13.627 -72.774 -8.950  1.00 38.18  ? 858  THR A CA  1 
ATOM   4347 C  C   . THR A 1 595 ? -14.865 -71.883 -9.074  1.00 37.06  ? 858  THR A C   1 
ATOM   4348 O  O   . THR A 1 595 ? -16.017 -72.382 -8.956  1.00 35.02  ? 858  THR A O   1 
ATOM   4349 C  CB  . THR A 1 595 ? -13.094 -72.672 -7.524  1.00 42.57  ? 858  THR A CB  1 
ATOM   4350 O  OG1 . THR A 1 595 ? -11.951 -73.525 -7.447  1.00 48.80  ? 858  THR A OG1 1 
ATOM   4351 C  CG2 . THR A 1 595 ? -14.153 -73.091 -6.528  1.00 41.65  ? 858  THR A CG2 1 
ATOM   4352 N  N   . TRP A 1 596 ? -14.625 -70.594 -9.228  1.00 32.74  ? 859  TRP A N   1 
ATOM   4353 C  CA  . TRP A 1 596 ? -15.682 -69.589 -9.486  1.00 33.34  ? 859  TRP A CA  1 
ATOM   4354 C  C   . TRP A 1 596 ? -16.506 -70.018 -10.703 1.00 31.20  ? 859  TRP A C   1 
ATOM   4355 O  O   . TRP A 1 596 ? -17.719 -70.077 -10.570 1.00 33.45  ? 859  TRP A O   1 
ATOM   4356 C  CB  . TRP A 1 596 ? -15.041 -68.220 -9.687  1.00 34.20  ? 859  TRP A CB  1 
ATOM   4357 C  CG  . TRP A 1 596 ? -15.920 -67.124 -10.180 1.00 29.30  ? 859  TRP A CG  1 
ATOM   4358 C  CD1 . TRP A 1 596 ? -16.942 -66.528 -9.505  1.00 32.64  ? 859  TRP A CD1 1 
ATOM   4359 C  CD2 . TRP A 1 596 ? -15.804 -66.443 -11.428 1.00 30.54  ? 859  TRP A CD2 1 
ATOM   4360 N  NE1 . TRP A 1 596 ? -17.442 -65.492 -10.241 1.00 30.72  ? 859  TRP A NE1 1 
ATOM   4361 C  CE2 . TRP A 1 596 ? -16.791 -65.436 -11.435 1.00 29.25  ? 859  TRP A CE2 1 
ATOM   4362 C  CE3 . TRP A 1 596 ? -14.958 -66.585 -12.539 1.00 32.56  ? 859  TRP A CE3 1 
ATOM   4363 C  CZ2 . TRP A 1 596 ? -16.947 -64.552 -12.494 1.00 29.50  ? 859  TRP A CZ2 1 
ATOM   4364 C  CZ3 . TRP A 1 596 ? -15.093 -65.699 -13.587 1.00 32.60  ? 859  TRP A CZ3 1 
ATOM   4365 C  CH2 . TRP A 1 596 ? -16.094 -64.707 -13.563 1.00 36.54  ? 859  TRP A CH2 1 
ATOM   4366 N  N   . ALA A 1 597 ? -15.872 -70.253 -11.841 1.00 31.28  ? 860  ALA A N   1 
ATOM   4367 C  CA  . ALA A 1 597 ? -16.532 -70.628 -13.122 1.00 36.06  ? 860  ALA A CA  1 
ATOM   4368 C  C   . ALA A 1 597 ? -17.340 -71.923 -12.979 1.00 40.08  ? 860  ALA A C   1 
ATOM   4369 O  O   . ALA A 1 597 ? -18.551 -71.942 -13.230 1.00 44.10  ? 860  ALA A O   1 
ATOM   4370 C  CB  . ALA A 1 597 ? -15.496 -70.772 -14.201 1.00 31.86  ? 860  ALA A CB  1 
ATOM   4371 N  N   . LYS A 1 598 ? -16.670 -72.966 -12.524 1.00 44.65  ? 861  LYS A N   1 
ATOM   4372 C  CA  . LYS A 1 598 ? -17.248 -74.305 -12.291 1.00 45.13  ? 861  LYS A CA  1 
ATOM   4373 C  C   . LYS A 1 598 ? -18.501 -74.183 -11.414 1.00 41.34  ? 861  LYS A C   1 
ATOM   4374 O  O   . LYS A 1 598 ? -19.501 -74.825 -11.761 1.00 39.69  ? 861  LYS A O   1 
ATOM   4375 C  CB  . LYS A 1 598 ? -16.145 -75.150 -11.645 1.00 54.57  ? 861  LYS A CB  1 
ATOM   4376 C  CG  . LYS A 1 598 ? -16.382 -76.647 -11.516 1.00 68.78  ? 861  LYS A CG  1 
ATOM   4377 C  CD  . LYS A 1 598 ? -15.576 -77.273 -10.369 1.00 83.08  ? 861  LYS A CD  1 
ATOM   4378 C  CE  . LYS A 1 598 ? -15.233 -78.733 -10.598 1.00 99.44  ? 861  LYS A CE  1 
ATOM   4379 N  NZ  . LYS A 1 598 ? -16.367 -79.491 -11.194 1.00 99.74  ? 861  LYS A NZ  1 
ATOM   4380 N  N   . ASN A 1 599 ? -18.450 -73.445 -10.302 1.00 35.28  ? 862  ASN A N   1 
ATOM   4381 C  CA  . ASN A 1 599 ? -19.577 -73.378 -9.325  1.00 37.21  ? 862  ASN A CA  1 
ATOM   4382 C  C   . ASN A 1 599 ? -20.431 -72.121 -9.495  1.00 30.61  ? 862  ASN A C   1 
ATOM   4383 O  O   . ASN A 1 599 ? -20.995 -71.651 -8.511  1.00 35.71  ? 862  ASN A O   1 
ATOM   4384 C  CB  . ASN A 1 599 ? -19.029 -73.459 -7.896  1.00 38.24  ? 862  ASN A CB  1 
ATOM   4385 C  CG  . ASN A 1 599 ? -18.248 -74.743 -7.706  1.00 42.93  ? 862  ASN A CG  1 
ATOM   4386 O  OD1 . ASN A 1 599 ? -18.765 -75.822 -7.935  1.00 46.77  ? 862  ASN A OD1 1 
ATOM   4387 N  ND2 . ASN A 1 599 ? -17.002 -74.641 -7.316  1.00 46.66  ? 862  ASN A ND2 1 
ATOM   4388 N  N   . ILE A 1 600 ? -20.476 -71.523 -10.671 1.00 32.69  ? 863  ILE A N   1 
ATOM   4389 C  CA  . ILE A 1 600 ? -21.120 -70.187 -10.845 1.00 31.32  ? 863  ILE A CA  1 
ATOM   4390 C  C   . ILE A 1 600 ? -22.644 -70.248 -10.537 1.00 34.52  ? 863  ILE A C   1 
ATOM   4391 O  O   . ILE A 1 600 ? -23.173 -69.298 -9.945  1.00 33.00  ? 863  ILE A O   1 
ATOM   4392 C  CB  . ILE A 1 600 ? -20.808 -69.623 -12.238 1.00 30.68  ? 863  ILE A CB  1 
ATOM   4393 C  CG1 . ILE A 1 600 ? -21.138 -68.135 -12.331 1.00 35.05  ? 863  ILE A CG1 1 
ATOM   4394 C  CG2 . ILE A 1 600 ? -21.482 -70.423 -13.348 1.00 31.68  ? 863  ILE A CG2 1 
ATOM   4395 C  CD1 . ILE A 1 600 ? -20.278 -67.248 -11.454 1.00 35.52  ? 863  ILE A CD1 1 
ATOM   4396 N  N   A GLN A 1 601 ? -23.316 -71.348 -10.903 0.23 33.80  ? 864  GLN A N   1 
ATOM   4397 N  N   B GLN A 1 601 ? -23.315 -71.349 -10.892 0.21 34.60  ? 864  GLN A N   1 
ATOM   4398 C  CA  A GLN A 1 601 ? -24.777 -71.536 -10.656 0.23 35.16  ? 864  GLN A CA  1 
ATOM   4399 C  CA  B GLN A 1 601 ? -24.780 -71.518 -10.661 0.21 36.43  ? 864  GLN A CA  1 
ATOM   4400 C  C   A GLN A 1 601 ? -25.074 -71.396 -9.154  0.23 34.81  ? 864  GLN A C   1 
ATOM   4401 C  C   B GLN A 1 601 ? -25.083 -71.414 -9.155  0.21 35.56  ? 864  GLN A C   1 
ATOM   4402 O  O   A GLN A 1 601 ? -26.148 -70.882 -8.809  0.23 36.21  ? 864  GLN A O   1 
ATOM   4403 O  O   B GLN A 1 601 ? -26.173 -70.934 -8.809  0.21 36.88  ? 864  GLN A O   1 
ATOM   4404 C  CB  A GLN A 1 601 ? -25.280 -72.877 -11.201 0.23 35.11  ? 864  GLN A CB  1 
ATOM   4405 C  CB  B GLN A 1 601 ? -25.283 -72.822 -11.289 0.21 37.41  ? 864  GLN A CB  1 
ATOM   4406 C  CG  A GLN A 1 601 ? -25.324 -72.965 -12.724 0.23 34.72  ? 864  GLN A CG  1 
ATOM   4407 C  CG  B GLN A 1 601 ? -26.797 -72.998 -11.238 0.21 37.37  ? 864  GLN A CG  1 
ATOM   4408 C  CD  A GLN A 1 601 ? -26.253 -71.974 -13.384 0.23 34.12  ? 864  GLN A CD  1 
ATOM   4409 C  CD  B GLN A 1 601 ? -27.570 -71.854 -11.850 0.21 40.18  ? 864  GLN A CD  1 
ATOM   4410 O  OE1 A GLN A 1 601 ? -27.114 -71.371 -12.747 0.23 37.09  ? 864  GLN A OE1 1 
ATOM   4411 O  OE1 B GLN A 1 601 ? -27.417 -71.528 -13.025 0.21 41.28  ? 864  GLN A OE1 1 
ATOM   4412 N  NE2 A GLN A 1 601 ? -26.092 -71.807 -14.686 0.23 32.79  ? 864  GLN A NE2 1 
ATOM   4413 N  NE2 B GLN A 1 601 ? -28.436 -71.247 -11.054 0.21 40.79  ? 864  GLN A NE2 1 
ATOM   4414 N  N   . THR A 1 602 ? -24.148 -71.810 -8.293  1.00 33.10  ? 865  THR A N   1 
ATOM   4415 C  CA  . THR A 1 602 ? -24.292 -71.667 -6.825  1.00 38.83  ? 865  THR A CA  1 
ATOM   4416 C  C   . THR A 1 602 ? -24.215 -70.193 -6.391  1.00 39.92  ? 865  THR A C   1 
ATOM   4417 O  O   . THR A 1 602 ? -24.813 -69.836 -5.370  1.00 39.31  ? 865  THR A O   1 
ATOM   4418 C  CB  . THR A 1 602 ? -23.198 -72.484 -6.135  1.00 40.90  ? 865  THR A CB  1 
ATOM   4419 O  OG1 . THR A 1 602 ? -23.327 -73.812 -6.661  1.00 46.35  ? 865  THR A OG1 1 
ATOM   4420 C  CG2 . THR A 1 602 ? -23.317 -72.432 -4.631  1.00 42.89  ? 865  THR A CG2 1 
ATOM   4421 N  N   . ALA A 1 603 ? -23.416 -69.374 -7.068  1.00 41.55  ? 866  ALA A N   1 
ATOM   4422 C  CA  . ALA A 1 603 ? -23.283 -67.943 -6.742  1.00 36.89  ? 866  ALA A CA  1 
ATOM   4423 C  C   . ALA A 1 603 ? -24.547 -67.258 -7.217  1.00 30.42  ? 866  ALA A C   1 
ATOM   4424 O  O   . ALA A 1 603 ? -25.080 -66.463 -6.468  1.00 28.52  ? 866  ALA A O   1 
ATOM   4425 C  CB  . ALA A 1 603 ? -22.084 -67.327 -7.419  1.00 33.93  ? 866  ALA A CB  1 
ATOM   4426 N  N   . ILE A 1 604 ? -24.940 -67.557 -8.452  1.00 30.58  ? 867  ILE A N   1 
ATOM   4427 C  CA  . ILE A 1 604 ? -26.213 -67.075 -9.067  1.00 31.48  ? 867  ILE A CA  1 
ATOM   4428 C  C   . ILE A 1 604 ? -27.383 -67.366 -8.112  1.00 30.40  ? 867  ILE A C   1 
ATOM   4429 O  O   . ILE A 1 604 ? -28.146 -66.441 -7.803  1.00 30.68  ? 867  ILE A O   1 
ATOM   4430 C  CB  . ILE A 1 604 ? -26.395 -67.711 -10.450 1.00 30.90  ? 867  ILE A CB  1 
ATOM   4431 C  CG1 . ILE A 1 604 ? -25.371 -67.140 -11.436 1.00 30.55  ? 867  ILE A CG1 1 
ATOM   4432 C  CG2 . ILE A 1 604 ? -27.824 -67.505 -10.956 1.00 31.67  ? 867  ILE A CG2 1 
ATOM   4433 C  CD1 . ILE A 1 604 ? -25.303 -67.902 -12.779 1.00 35.15  ? 867  ILE A CD1 1 
ATOM   4434 N  N   . ASN A 1 605 ? -27.477 -68.595 -7.599  1.00 35.62  ? 868  ASN A N   1 
ATOM   4435 C  CA  . ASN A 1 605 ? -28.556 -69.018 -6.657  1.00 35.09  ? 868  ASN A CA  1 
ATOM   4436 C  C   . ASN A 1 605 ? -28.424 -68.251 -5.337  1.00 35.90  ? 868  ASN A C   1 
ATOM   4437 O  O   . ASN A 1 605 ? -29.462 -67.915 -4.756  1.00 32.79  ? 868  ASN A O   1 
ATOM   4438 C  CB  . ASN A 1 605 ? -28.564 -70.535 -6.445  1.00 40.14  ? 868  ASN A CB  1 
ATOM   4439 C  CG  . ASN A 1 605 ? -28.986 -71.328 -7.674  1.00 45.92  ? 868  ASN A CG  1 
ATOM   4440 O  OD1 . ASN A 1 605 ? -29.645 -70.827 -8.588  1.00 54.04  ? 868  ASN A OD1 1 
ATOM   4441 N  ND2 . ASN A 1 605 ? -28.580 -72.583 -7.725  1.00 52.64  ? 868  ASN A ND2 1 
ATOM   4442 N  N   . GLN A 1 606 ? -27.211 -67.947 -4.854  1.00 36.60  ? 869  GLN A N   1 
ATOM   4443 C  CA  . GLN A 1 606 ? -27.078 -67.154 -3.600  1.00 36.09  ? 869  GLN A CA  1 
ATOM   4444 C  C   . GLN A 1 606 ? -27.781 -65.800 -3.780  1.00 34.95  ? 869  GLN A C   1 
ATOM   4445 O  O   . GLN A 1 606 ? -28.536 -65.351 -2.859  1.00 35.19  ? 869  GLN A O   1 
ATOM   4446 C  CB  . GLN A 1 606 ? -25.638 -66.916 -3.158  1.00 39.47  ? 869  GLN A CB  1 
ATOM   4447 C  CG  . GLN A 1 606 ? -25.553 -66.092 -1.851  1.00 44.97  ? 869  GLN A CG  1 
ATOM   4448 C  CD  . GLN A 1 606 ? -24.135 -65.802 -1.395  1.00 56.09  ? 869  GLN A CD  1 
ATOM   4449 O  OE1 . GLN A 1 606 ? -23.213 -65.716 -2.222  1.00 55.50  ? 869  GLN A OE1 1 
ATOM   4450 N  NE2 . GLN A 1 606 ? -23.939 -65.705 -0.082  1.00 45.29  ? 869  GLN A NE2 1 
ATOM   4451 N  N   . VAL A 1 607 ? -27.516 -65.130 -4.894  1.00 29.57  ? 870  VAL A N   1 
ATOM   4452 C  CA  . VAL A 1 607 ? -28.088 -63.783 -5.127  1.00 31.91  ? 870  VAL A CA  1 
ATOM   4453 C  C   . VAL A 1 607 ? -29.615 -63.923 -5.395  1.00 30.34  ? 870  VAL A C   1 
ATOM   4454 O  O   . VAL A 1 607 ? -30.372 -63.097 -4.871  1.00 29.70  ? 870  VAL A O   1 
ATOM   4455 C  CB  . VAL A 1 607 ? -27.353 -63.077 -6.274  1.00 31.54  ? 870  VAL A CB  1 
ATOM   4456 C  CG1 . VAL A 1 607 ? -28.083 -61.797 -6.675  1.00 28.14  ? 870  VAL A CG1 1 
ATOM   4457 C  CG2 . VAL A 1 607 ? -25.893 -62.840 -5.918  1.00 33.14  ? 870  VAL A CG2 1 
ATOM   4458 N  N   . ARG A 1 608 ? -30.049 -64.923 -6.156  1.00 27.63  ? 871  ARG A N   1 
ATOM   4459 C  CA  . ARG A 1 608 ? -31.513 -65.168 -6.401  1.00 31.67  ? 871  ARG A CA  1 
ATOM   4460 C  C   . ARG A 1 608 ? -32.241 -65.326 -5.067  1.00 33.55  ? 871  ARG A C   1 
ATOM   4461 O  O   . ARG A 1 608 ? -33.277 -64.691 -4.882  1.00 38.19  ? 871  ARG A O   1 
ATOM   4462 C  CB  . ARG A 1 608 ? -31.718 -66.393 -7.287  1.00 28.88  ? 871  ARG A CB  1 
ATOM   4463 C  CG  . ARG A 1 608 ? -31.372 -66.109 -8.752  1.00 31.20  ? 871  ARG A CG  1 
ATOM   4464 C  CD  . ARG A 1 608 ? -31.633 -67.308 -9.613  1.00 32.46  ? 871  ARG A CD  1 
ATOM   4465 N  NE  . ARG A 1 608 ? -31.462 -67.025 -11.029 1.00 35.74  ? 871  ARG A NE  1 
ATOM   4466 C  CZ  . ARG A 1 608 ? -31.366 -67.965 -11.964 1.00 36.31  ? 871  ARG A CZ  1 
ATOM   4467 N  NH1 . ARG A 1 608 ? -31.423 -69.233 -11.606 1.00 42.89  ? 871  ARG A NH1 1 
ATOM   4468 N  NH2 . ARG A 1 608 ? -31.174 -67.660 -13.233 1.00 38.27  ? 871  ARG A NH2 1 
ATOM   4469 N  N   . SER A 1 609 ? -31.667 -66.076 -4.139  1.00 32.37  ? 872  SER A N   1 
ATOM   4470 C  CA  . SER A 1 609 ? -32.266 -66.308 -2.804  1.00 34.27  ? 872  SER A CA  1 
ATOM   4471 C  C   . SER A 1 609 ? -32.370 -65.016 -2.018  1.00 34.56  ? 872  SER A C   1 
ATOM   4472 O  O   . SER A 1 609 ? -33.280 -64.921 -1.205  1.00 37.75  ? 872  SER A O   1 
ATOM   4473 C  CB  . SER A 1 609 ? -31.491 -67.330 -2.050  1.00 36.37  ? 872  SER A CB  1 
ATOM   4474 O  OG  . SER A 1 609 ? -31.439 -68.532 -2.812  1.00 35.07  ? 872  SER A OG  1 
ATOM   4475 N  N   . LEU A 1 610 ? -31.479 -64.053 -2.246  1.00 33.95  ? 873  LEU A N   1 
ATOM   4476 C  CA  . LEU A 1 610 ? -31.473 -62.768 -1.506  1.00 33.81  ? 873  LEU A CA  1 
ATOM   4477 C  C   . LEU A 1 610 ? -32.564 -61.858 -2.068  1.00 34.82  ? 873  LEU A C   1 
ATOM   4478 O  O   . LEU A 1 610 ? -33.316 -61.271 -1.281  1.00 34.12  ? 873  LEU A O   1 
ATOM   4479 C  CB  . LEU A 1 610 ? -30.082 -62.134 -1.632  1.00 36.14  ? 873  LEU A CB  1 
ATOM   4480 C  CG  . LEU A 1 610 ? -28.990 -62.785 -0.789  1.00 35.69  ? 873  LEU A CG  1 
ATOM   4481 C  CD1 . LEU A 1 610 ? -27.629 -62.154 -1.082  1.00 37.26  ? 873  LEU A CD1 1 
ATOM   4482 C  CD2 . LEU A 1 610 ? -29.308 -62.698 0.708   1.00 36.36  ? 873  LEU A CD2 1 
ATOM   4483 N  N   . ILE A 1 611 ? -32.634 -61.755 -3.388  1.00 32.94  ? 874  ILE A N   1 
ATOM   4484 C  CA  . ILE A 1 611 ? -33.637 -60.920 -4.095  1.00 35.85  ? 874  ILE A CA  1 
ATOM   4485 C  C   . ILE A 1 611 ? -35.039 -61.529 -3.887  1.00 38.87  ? 874  ILE A C   1 
ATOM   4486 O  O   . ILE A 1 611 ? -35.926 -60.783 -3.493  1.00 38.37  ? 874  ILE A O   1 
ATOM   4487 C  CB  . ILE A 1 611 ? -33.240 -60.749 -5.570  1.00 37.24  ? 874  ILE A CB  1 
ATOM   4488 C  CG1 . ILE A 1 611 ? -31.900 -60.010 -5.678  1.00 38.13  ? 874  ILE A CG1 1 
ATOM   4489 C  CG2 . ILE A 1 611 ? -34.352 -60.025 -6.312  1.00 40.25  ? 874  ILE A CG2 1 
ATOM   4490 C  CD1 . ILE A 1 611 ? -31.313 -59.952 -7.054  1.00 38.76  ? 874  ILE A CD1 1 
ATOM   4491 N  N   . GLY A 1 612 ? -35.191 -62.847 -4.030  1.00 37.00  ? 875  GLY A N   1 
ATOM   4492 C  CA  . GLY A 1 612 ? -36.403 -63.610 -3.666  1.00 44.16  ? 875  GLY A CA  1 
ATOM   4493 C  C   . GLY A 1 612 ? -37.008 -64.338 -4.860  1.00 47.38  ? 875  GLY A C   1 
ATOM   4494 O  O   . GLY A 1 612 ? -36.322 -64.508 -5.888  1.00 40.63  ? 875  GLY A O   1 
ATOM   4495 N  N   . ASN A 1 613 ? -38.301 -64.661 -4.774  1.00 54.90  ? 876  ASN A N   1 
ATOM   4496 C  CA  . ASN A 1 613 ? -39.032 -65.489 -5.775  1.00 53.18  ? 876  ASN A CA  1 
ATOM   4497 C  C   . ASN A 1 613 ? -39.541 -64.586 -6.907  1.00 47.71  ? 876  ASN A C   1 
ATOM   4498 O  O   . ASN A 1 613 ? -40.668 -64.092 -6.814  1.00 63.77  ? 876  ASN A O   1 
ATOM   4499 C  CB  . ASN A 1 613 ? -40.169 -66.268 -5.102  1.00 61.77  ? 876  ASN A CB  1 
ATOM   4500 C  CG  . ASN A 1 613 ? -40.784 -67.305 -6.015  1.00 68.27  ? 876  ASN A CG  1 
ATOM   4501 O  OD1 . ASN A 1 613 ? -40.228 -67.622 -7.061  1.00 66.64  ? 876  ASN A OD1 1 
ATOM   4502 N  ND2 . ASN A 1 613 ? -41.923 -67.854 -5.622  1.00 72.75  ? 876  ASN A ND2 1 
ATOM   4503 N  N   . GLU A 1 614 ? -38.733 -64.415 -7.944  1.00 39.16  ? 877  GLU A N   1 
ATOM   4504 C  CA  . GLU A 1 614 ? -38.917 -63.470 -9.071  1.00 35.95  ? 877  GLU A CA  1 
ATOM   4505 C  C   . GLU A 1 614 ? -38.746 -64.314 -10.315 1.00 35.83  ? 877  GLU A C   1 
ATOM   4506 O  O   . GLU A 1 614 ? -38.485 -65.526 -10.128 1.00 35.22  ? 877  GLU A O   1 
ATOM   4507 C  CB  . GLU A 1 614 ? -37.892 -62.339 -9.006  1.00 39.67  ? 877  GLU A CB  1 
ATOM   4508 C  CG  . GLU A 1 614 ? -38.012 -61.482 -7.767  1.00 38.30  ? 877  GLU A CG  1 
ATOM   4509 C  CD  . GLU A 1 614 ? -39.152 -60.467 -7.793  1.00 38.97  ? 877  GLU A CD  1 
ATOM   4510 O  OE1 . GLU A 1 614 ? -39.711 -60.235 -8.879  1.00 35.62  ? 877  GLU A OE1 1 
ATOM   4511 O  OE2 . GLU A 1 614 ? -39.416 -59.840 -6.738  1.00 38.69  ? 877  GLU A OE2 1 
ATOM   4512 N  N   . GLU A 1 615 ? -39.012 -63.763 -11.502 1.00 40.65  ? 878  GLU A N   1 
ATOM   4513 C  CA  . GLU A 1 615 ? -38.804 -64.520 -12.765 1.00 44.26  ? 878  GLU A CA  1 
ATOM   4514 C  C   . GLU A 1 615 ? -37.341 -64.273 -13.148 1.00 44.40  ? 878  GLU A C   1 
ATOM   4515 O  O   . GLU A 1 615 ? -36.989 -63.102 -13.299 1.00 41.21  ? 878  GLU A O   1 
ATOM   4516 C  CB  . GLU A 1 615 ? -39.727 -64.116 -13.929 1.00 49.43  ? 878  GLU A CB  1 
ATOM   4517 C  CG  . GLU A 1 615 ? -39.536 -65.025 -15.158 1.00 59.28  ? 878  GLU A CG  1 
ATOM   4518 C  CD  . GLU A 1 615 ? -40.224 -64.623 -16.462 1.00 77.50  ? 878  GLU A CD  1 
ATOM   4519 O  OE1 . GLU A 1 615 ? -40.785 -63.500 -16.533 1.00 77.38  ? 878  GLU A OE1 1 
ATOM   4520 O  OE2 . GLU A 1 615 ? -40.220 -65.450 -17.418 1.00 86.10  ? 878  GLU A OE2 1 
ATOM   4521 N  N   . TYR A 1 616 ? -36.579 -65.347 -13.324 1.00 43.98  ? 879  TYR A N   1 
ATOM   4522 C  CA  . TYR A 1 616 ? -35.153 -65.355 -13.723 1.00 48.06  ? 879  TYR A CA  1 
ATOM   4523 C  C   . TYR A 1 616 ? -34.961 -66.184 -14.997 1.00 48.65  ? 879  TYR A C   1 
ATOM   4524 O  O   . TYR A 1 616 ? -35.666 -67.190 -15.198 1.00 41.61  ? 879  TYR A O   1 
ATOM   4525 C  CB  . TYR A 1 616 ? -34.292 -65.924 -12.594 1.00 42.36  ? 879  TYR A CB  1 
ATOM   4526 C  CG  . TYR A 1 616 ? -34.384 -65.213 -11.270 1.00 38.52  ? 879  TYR A CG  1 
ATOM   4527 C  CD1 . TYR A 1 616 ? -33.643 -64.072 -11.023 1.00 37.38  ? 879  TYR A CD1 1 
ATOM   4528 C  CD2 . TYR A 1 616 ? -35.134 -65.730 -10.228 1.00 38.65  ? 879  TYR A CD2 1 
ATOM   4529 C  CE1 . TYR A 1 616 ? -33.670 -63.436 -9.788  1.00 39.03  ? 879  TYR A CE1 1 
ATOM   4530 C  CE2 . TYR A 1 616 ? -35.146 -65.129 -8.975  1.00 36.89  ? 879  TYR A CE2 1 
ATOM   4531 C  CZ  . TYR A 1 616 ? -34.431 -63.967 -8.756  1.00 39.39  ? 879  TYR A CZ  1 
ATOM   4532 O  OH  . TYR A 1 616 ? -34.446 -63.338 -7.536  1.00 41.16  ? 879  TYR A OH  1 
ATOM   4533 N  N   . THR A 1 617 ? -33.977 -65.778 -15.812 1.00 49.02  ? 880  THR A N   1 
ATOM   4534 C  CA  . THR A 1 617 ? -33.480 -66.518 -17.005 1.00 47.81  ? 880  THR A CA  1 
ATOM   4535 C  C   . THR A 1 617 ? -32.076 -67.080 -16.715 1.00 46.87  ? 880  THR A C   1 
ATOM   4536 O  O   . THR A 1 617 ? -31.257 -66.360 -16.128 1.00 43.13  ? 880  THR A O   1 
ATOM   4537 C  CB  . THR A 1 617 ? -33.416 -65.555 -18.196 1.00 52.87  ? 880  THR A CB  1 
ATOM   4538 O  OG1 . THR A 1 617 ? -34.686 -64.908 -18.281 1.00 47.85  ? 880  THR A OG1 1 
ATOM   4539 C  CG2 . THR A 1 617 ? -33.070 -66.230 -19.502 1.00 48.20  ? 880  THR A CG2 1 
ATOM   4540 N  N   . ASP A 1 618 ? -31.778 -68.304 -17.141 1.00 45.19  ? 881  ASP A N   1 
ATOM   4541 C  CA  . ASP A 1 618 ? -30.396 -68.833 -17.109 1.00 47.44  ? 881  ASP A CA  1 
ATOM   4542 C  C   . ASP A 1 618 ? -29.711 -68.387 -18.414 1.00 43.14  ? 881  ASP A C   1 
ATOM   4543 O  O   . ASP A 1 618 ? -30.044 -68.945 -19.488 1.00 40.62  ? 881  ASP A O   1 
ATOM   4544 C  CB  . ASP A 1 618 ? -30.405 -70.347 -16.864 1.00 50.39  ? 881  ASP A CB  1 
ATOM   4545 C  CG  . ASP A 1 618 ? -29.017 -70.997 -16.778 1.00 63.25  ? 881  ASP A CG  1 
ATOM   4546 O  OD1 . ASP A 1 618 ? -28.008 -70.255 -16.538 1.00 52.59  ? 881  ASP A OD1 1 
ATOM   4547 O  OD2 . ASP A 1 618 ? -28.938 -72.259 -16.948 1.00 65.74  ? 881  ASP A OD2 1 
ATOM   4548 N  N   . TYR A 1 619 ? -28.781 -67.425 -18.353 1.00 40.77  ? 882  TYR A N   1 
ATOM   4549 C  CA  . TYR A 1 619 ? -27.978 -67.027 -19.544 1.00 39.68  ? 882  TYR A CA  1 
ATOM   4550 C  C   . TYR A 1 619 ? -26.648 -67.800 -19.718 1.00 40.35  ? 882  TYR A C   1 
ATOM   4551 O  O   . TYR A 1 619 ? -25.964 -67.600 -20.740 1.00 39.87  ? 882  TYR A O   1 
ATOM   4552 C  CB  . TYR A 1 619 ? -27.733 -65.517 -19.524 1.00 39.18  ? 882  TYR A CB  1 
ATOM   4553 C  CG  . TYR A 1 619 ? -28.955 -64.669 -19.759 1.00 43.44  ? 882  TYR A CG  1 
ATOM   4554 C  CD1 . TYR A 1 619 ? -29.506 -64.548 -21.028 1.00 44.47  ? 882  TYR A CD1 1 
ATOM   4555 C  CD2 . TYR A 1 619 ? -29.537 -63.951 -18.729 1.00 40.99  ? 882  TYR A CD2 1 
ATOM   4556 C  CE1 . TYR A 1 619 ? -30.633 -63.774 -21.265 1.00 42.61  ? 882  TYR A CE1 1 
ATOM   4557 C  CE2 . TYR A 1 619 ? -30.657 -63.162 -18.948 1.00 44.43  ? 882  TYR A CE2 1 
ATOM   4558 C  CZ  . TYR A 1 619 ? -31.211 -63.073 -20.217 1.00 48.09  ? 882  TYR A CZ  1 
ATOM   4559 O  OH  . TYR A 1 619 ? -32.301 -62.267 -20.430 1.00 47.34  ? 882  TYR A OH  1 
ATOM   4560 N  N   . MET A 1 620 ? -26.287 -68.669 -18.769 0.44 40.42  ? 883  MET A N   1 
ATOM   4561 C  CA  . MET A 1 620 ? -24.963 -69.355 -18.766 0.44 42.25  ? 883  MET A CA  1 
ATOM   4562 C  C   . MET A 1 620 ? -24.822 -70.310 -19.961 0.44 46.57  ? 883  MET A C   1 
ATOM   4563 O  O   . MET A 1 620 ? -23.741 -70.380 -20.553 0.44 50.57  ? 883  MET A O   1 
ATOM   4564 C  CB  . MET A 1 620 ? -24.709 -70.098 -17.449 0.44 40.42  ? 883  MET A CB  1 
ATOM   4565 C  CG  . MET A 1 620 ? -24.800 -69.215 -16.200 0.44 41.32  ? 883  MET A CG  1 
ATOM   4566 S  SD  . MET A 1 620 ? -23.979 -67.593 -16.349 0.44 42.40  ? 883  MET A SD  1 
ATOM   4567 C  CE  . MET A 1 620 ? -22.296 -68.111 -16.692 0.44 39.97  ? 883  MET A CE  1 
ATOM   4568 N  N   . PRO A 1 621 ? -25.872 -71.064 -20.378 0.44 48.99  ? 884  PRO A N   1 
ATOM   4569 C  CA  . PRO A 1 621 ? -25.785 -71.925 -21.566 0.44 48.57  ? 884  PRO A CA  1 
ATOM   4570 C  C   . PRO A 1 621 ? -25.496 -71.218 -22.902 0.44 48.16  ? 884  PRO A C   1 
ATOM   4571 O  O   . PRO A 1 621 ? -25.259 -71.912 -23.863 0.44 50.56  ? 884  PRO A O   1 
ATOM   4572 C  CB  . PRO A 1 621 ? -27.175 -72.591 -21.642 0.44 49.67  ? 884  PRO A CB  1 
ATOM   4573 C  CG  . PRO A 1 621 ? -27.703 -72.523 -20.227 0.44 48.37  ? 884  PRO A CG  1 
ATOM   4574 C  CD  . PRO A 1 621 ? -27.173 -71.205 -19.700 0.44 50.30  ? 884  PRO A CD  1 
ATOM   4575 N  N   . SER A 1 622 ? -25.513 -69.880 -22.942 0.44 49.50  ? 885  SER A N   1 
ATOM   4576 C  CA  . SER A 1 622 ? -25.052 -69.060 -24.099 0.44 51.91  ? 885  SER A CA  1 
ATOM   4577 C  C   . SER A 1 622 ? -23.542 -69.253 -24.322 0.44 52.68  ? 885  SER A C   1 
ATOM   4578 O  O   . SER A 1 622 ? -23.061 -68.939 -25.428 0.44 52.48  ? 885  SER A O   1 
ATOM   4579 C  CB  . SER A 1 622 ? -25.388 -67.600 -23.905 0.44 51.10  ? 885  SER A CB  1 
ATOM   4580 O  OG  . SER A 1 622 ? -24.537 -67.000 -22.939 0.44 50.71  ? 885  SER A OG  1 
ATOM   4581 N  N   . MET A 1 623 ? -22.828 -69.725 -23.294 0.44 53.23  ? 886  MET A N   1 
ATOM   4582 C  CA  . MET A 1 623 ? -21.374 -70.036 -23.323 0.44 57.09  ? 886  MET A CA  1 
ATOM   4583 C  C   . MET A 1 623 ? -21.201 -71.545 -23.514 0.44 60.61  ? 886  MET A C   1 
ATOM   4584 O  O   . MET A 1 623 ? -21.898 -72.305 -22.801 0.44 58.53  ? 886  MET A O   1 
ATOM   4585 C  CB  . MET A 1 623 ? -20.695 -69.625 -22.012 0.44 57.50  ? 886  MET A CB  1 
ATOM   4586 C  CG  . MET A 1 623 ? -21.092 -68.247 -21.518 0.44 59.68  ? 886  MET A CG  1 
ATOM   4587 S  SD  . MET A 1 623 ? -20.194 -67.787 -20.019 0.44 56.38  ? 886  MET A SD  1 
ATOM   4588 C  CE  . MET A 1 623 ? -18.612 -67.348 -20.737 0.44 57.33  ? 886  MET A CE  1 
ATOM   4589 N  N   . LYS A 1 624 ? -20.289 -71.948 -24.408 0.44 64.96  ? 887  LYS A N   1 
ATOM   4590 C  CA  . LYS A 1 624 ? -20.049 -73.358 -24.828 0.44 65.87  ? 887  LYS A CA  1 
ATOM   4591 C  C   . LYS A 1 624 ? -19.884 -74.267 -23.599 0.44 65.15  ? 887  LYS A C   1 
ATOM   4592 O  O   . LYS A 1 624 ? -20.482 -75.367 -23.595 0.44 61.58  ? 887  LYS A O   1 
ATOM   4593 C  CB  . LYS A 1 624 ? -18.822 -73.424 -25.745 0.44 69.70  ? 887  LYS A CB  1 
ATOM   4594 C  CG  . LYS A 1 624 ? -18.358 -74.826 -26.119 0.44 74.01  ? 887  LYS A CG  1 
ATOM   4595 C  CD  . LYS A 1 624 ? -17.560 -74.886 -27.411 0.44 76.90  ? 887  LYS A CD  1 
ATOM   4596 C  CE  . LYS A 1 624 ? -16.573 -76.037 -27.454 0.44 76.93  ? 887  LYS A CE  1 
ATOM   4597 N  NZ  . LYS A 1 624 ? -15.446 -75.834 -26.512 0.44 76.06  ? 887  LYS A NZ  1 
ATOM   4598 N  N   . ARG A 1 625 ? -19.127 -73.827 -22.590 0.44 64.70  ? 888  ARG A N   1 
ATOM   4599 C  CA  . ARG A 1 625 ? -18.740 -74.668 -21.422 0.44 65.09  ? 888  ARG A CA  1 
ATOM   4600 C  C   . ARG A 1 625 ? -19.970 -75.017 -20.569 0.44 63.72  ? 888  ARG A C   1 
ATOM   4601 O  O   . ARG A 1 625 ? -19.927 -76.070 -19.906 0.44 63.13  ? 888  ARG A O   1 
ATOM   4602 C  CB  . ARG A 1 625 ? -17.660 -73.982 -20.579 0.44 65.57  ? 888  ARG A CB  1 
ATOM   4603 C  CG  . ARG A 1 625 ? -18.112 -72.733 -19.833 0.44 65.01  ? 888  ARG A CG  1 
ATOM   4604 C  CD  . ARG A 1 625 ? -17.052 -72.282 -18.845 0.44 63.82  ? 888  ARG A CD  1 
ATOM   4605 N  NE  . ARG A 1 625 ? -16.891 -73.244 -17.761 0.44 62.51  ? 888  ARG A NE  1 
ATOM   4606 C  CZ  . ARG A 1 625 ? -15.834 -73.326 -16.954 0.44 62.79  ? 888  ARG A CZ  1 
ATOM   4607 N  NH1 . ARG A 1 625 ? -14.808 -72.498 -17.092 0.44 65.54  ? 888  ARG A NH1 1 
ATOM   4608 N  NH2 . ARG A 1 625 ? -15.807 -74.247 -16.005 0.44 60.41  ? 888  ARG A NH2 1 
ATOM   4609 N  N   . PHE A 1 626 ? -21.003 -74.163 -20.558 0.44 62.92  ? 889  PHE A N   1 
ATOM   4610 C  CA  . PHE A 1 626 ? -22.254 -74.366 -19.776 0.44 64.81  ? 889  PHE A CA  1 
ATOM   4611 C  C   . PHE A 1 626 ? -23.378 -74.870 -20.692 0.44 68.22  ? 889  PHE A C   1 
ATOM   4612 O  O   . PHE A 1 626 ? -24.480 -75.165 -20.182 0.44 67.24  ? 889  PHE A O   1 
ATOM   4613 C  CB  . PHE A 1 626 ? -22.669 -73.077 -19.061 0.44 63.09  ? 889  PHE A CB  1 
ATOM   4614 C  CG  . PHE A 1 626 ? -21.601 -72.485 -18.177 0.44 63.85  ? 889  PHE A CG  1 
ATOM   4615 C  CD1 . PHE A 1 626 ? -21.226 -73.111 -16.998 0.44 63.39  ? 889  PHE A CD1 1 
ATOM   4616 C  CD2 . PHE A 1 626 ? -20.957 -71.309 -18.533 0.44 63.64  ? 889  PHE A CD2 1 
ATOM   4617 C  CE1 . PHE A 1 626 ? -20.232 -72.571 -16.194 0.44 64.72  ? 889  PHE A CE1 1 
ATOM   4618 C  CE2 . PHE A 1 626 ? -19.967 -70.768 -17.727 0.44 63.12  ? 889  PHE A CE2 1 
ATOM   4619 C  CZ  . PHE A 1 626 ? -19.608 -71.398 -16.557 0.44 63.98  ? 889  PHE A CZ  1 
ATOM   4620 N  N   . ARG A 1 627 ? -23.120 -74.977 -21.999 0.44 72.64  ? 890  ARG A N   1 
ATOM   4621 C  CA  . ARG A 1 627 ? -24.115 -75.462 -22.993 0.44 77.72  ? 890  ARG A CA  1 
ATOM   4622 C  C   . ARG A 1 627 ? -24.226 -76.987 -22.851 0.44 78.45  ? 890  ARG A C   1 
ATOM   4623 O  O   . ARG A 1 627 ? -23.882 -77.698 -23.817 0.44 78.69  ? 890  ARG A O   1 
ATOM   4624 C  CB  . ARG A 1 627 ? -23.726 -75.029 -24.413 0.44 77.58  ? 890  ARG A CB  1 
ATOM   4625 C  CG  . ARG A 1 627 ? -24.917 -74.815 -25.338 0.44 78.71  ? 890  ARG A CG  1 
ATOM   4626 C  CD  . ARG A 1 627 ? -24.691 -75.210 -26.787 0.44 80.21  ? 890  ARG A CD  1 
ATOM   4627 N  NE  . ARG A 1 627 ? -23.401 -74.807 -27.337 0.44 80.99  ? 890  ARG A NE  1 
ATOM   4628 C  CZ  . ARG A 1 627 ? -22.307 -75.572 -27.391 0.44 81.70  ? 890  ARG A CZ  1 
ATOM   4629 N  NH1 . ARG A 1 627 ? -22.312 -76.805 -26.911 0.44 80.25  ? 890  ARG A NH1 1 
ATOM   4630 N  NH2 . ARG A 1 627 ? -21.195 -75.094 -27.923 0.44 83.38  ? 890  ARG A NH2 1 
ATOM   4631 N  N   . ARG A 1 628 ? -24.687 -77.459 -21.684 0.44 77.81  ? 891  ARG A N   1 
ATOM   4632 C  CA  . ARG A 1 628 ? -24.758 -78.898 -21.313 0.44 78.51  ? 891  ARG A CA  1 
ATOM   4633 C  C   . ARG A 1 628 ? -26.000 -79.138 -20.445 0.44 78.55  ? 891  ARG A C   1 
ATOM   4634 O  O   . ARG A 1 628 ? -26.436 -80.278 -20.253 0.44 78.38  ? 891  ARG A O   1 
ATOM   4635 C  CB  . ARG A 1 628 ? -23.484 -79.322 -20.574 0.44 79.49  ? 891  ARG A CB  1 
ATOM   4636 C  CG  . ARG A 1 628 ? -22.194 -79.098 -21.355 0.44 81.23  ? 891  ARG A CG  1 
ATOM   4637 C  CD  . ARG A 1 628 ? -20.968 -79.614 -20.622 0.44 79.51  ? 891  ARG A CD  1 
ATOM   4638 N  NE  . ARG A 1 628 ? -19.727 -79.321 -21.327 0.44 78.24  ? 891  ARG A NE  1 
ATOM   4639 C  CZ  . ARG A 1 628 ? -18.512 -79.694 -20.927 0.44 78.20  ? 891  ARG A CZ  1 
ATOM   4640 N  NH1 . ARG A 1 628 ? -18.351 -80.384 -19.809 0.44 74.73  ? 891  ARG A NH1 1 
ATOM   4641 N  NH2 . ARG A 1 628 ? -17.455 -79.373 -21.652 0.44 78.43  ? 891  ARG A NH2 1 
HETATM 4642 ZN ZN  . ZN  B 2 .   ? -6.464  -55.071 -23.710 1.00 28.68  2 1001 ZN  A ZN  1 
HETATM 4643 ZN ZN  . ZN  C 2 .   ? -25.635 -14.217 -13.440 1.00 58.11  2 1002 ZN  A ZN  1 
HETATM 4644 O  O1  A MES D 3 .   ? -28.270 -57.807 -0.562  0.23 999.00 ? 1003 MES A O1  1 
HETATM 4645 O  O1  B MES D 3 .   ? -28.158 -57.681 -0.232  0.21 39.56  ? 1003 MES A O1  1 
HETATM 4646 C  C2  A MES D 3 .   ? -27.896 -58.073 0.781   0.23 999.00 ? 1003 MES A C2  1 
HETATM 4647 C  C2  B MES D 3 .   ? -27.552 -58.416 0.819   0.21 34.50  ? 1003 MES A C2  1 
HETATM 4648 C  C3  A MES D 3 .   ? -26.492 -57.601 1.063   0.23 999.00 ? 1003 MES A C3  1 
HETATM 4649 C  C3  B MES D 3 .   ? -26.070 -58.147 0.878   0.21 34.89  ? 1003 MES A C3  1 
HETATM 4650 N  N4  A MES D 3 .   ? -25.535 -58.275 0.133   0.23 999.00 ? 1003 MES A N4  1 
HETATM 4651 N  N4  B MES D 3 .   ? -25.530 -57.994 -0.507  0.21 27.71  ? 1003 MES A N4  1 
HETATM 4652 C  C5  A MES D 3 .   ? -25.974 -58.043 -1.278  0.23 999.00 ? 1003 MES A C5  1 
HETATM 4653 C  C5  B MES D 3 .   ? -26.378 -58.783 -1.453  0.21 38.53  ? 1003 MES A C5  1 
HETATM 4654 C  C6  A MES D 3 .   ? -27.402 -58.492 -1.451  0.23 999.00 ? 1003 MES A C6  1 
HETATM 4655 C  C6  B MES D 3 .   ? -27.779 -58.226 -1.487  0.21 26.32  ? 1003 MES A C6  1 
HETATM 4656 C  C7  A MES D 3 .   ? -24.125 -57.814 0.354   0.23 999.00 ? 1003 MES A C7  1 
HETATM 4657 C  C7  B MES D 3 .   ? -24.089 -58.404 -0.581  0.21 35.29  ? 1003 MES A C7  1 
HETATM 4658 C  C8  A MES D 3 .   ? -23.126 -58.519 -0.541  0.23 999.00 ? 1003 MES A C8  1 
HETATM 4659 C  C8  B MES D 3 .   ? -23.189 -57.595 0.330   0.21 23.90  ? 1003 MES A C8  1 
HETATM 4660 S  S   A MES D 3 .   ? -21.456 -57.964 -0.288  0.23 999.00 ? 1003 MES A S   1 
HETATM 4661 S  S   B MES D 3 .   ? -21.473 -58.029 0.163   0.21 22.03  ? 1003 MES A S   1 
HETATM 4662 O  O1S A MES D 3 .   ? -21.121 -58.313 1.062   0.23 999.00 ? 1003 MES A O1S 1 
HETATM 4663 O  O1S B MES D 3 .   ? -21.401 -59.447 0.365   0.21 23.97  ? 1003 MES A O1S 1 
HETATM 4664 O  O2S A MES D 3 .   ? -20.660 -58.662 -1.255  0.23 744.35 ? 1003 MES A O2S 1 
HETATM 4665 O  O2S B MES D 3 .   ? -21.088 -57.639 -1.162  0.21 29.07  ? 1003 MES A O2S 1 
HETATM 4666 O  O3S A MES D 3 .   ? -21.468 -56.547 -0.504  0.23 826.99 ? 1003 MES A O3S 1 
HETATM 4667 O  O3S B MES D 3 .   ? -20.779 -57.294 1.180   0.21 26.39  ? 1003 MES A O3S 1 
HETATM 4668 S  S   . DMS E 4 .   ? -26.674 -61.773 -21.038 1.00 60.67  ? 1004 DMS A S   1 
HETATM 4669 O  O   . DMS E 4 .   ? -26.595 -62.459 -22.409 1.00 51.52  ? 1004 DMS A O   1 
HETATM 4670 C  C1  . DMS E 4 .   ? -27.950 -60.557 -21.157 1.00 58.95  ? 1004 DMS A C1  1 
HETATM 4671 C  C2  . DMS E 4 .   ? -25.265 -60.691 -21.102 1.00 57.59  ? 1004 DMS A C2  1 
HETATM 4672 S  S   . DMS F 4 .   ? -15.816 -69.384 -28.980 0.44 98.68  ? 1005 DMS A S   1 
HETATM 4673 O  O   . DMS F 4 .   ? -16.232 -67.945 -29.110 0.44 93.61  ? 1005 DMS A O   1 
HETATM 4674 C  C1  . DMS F 4 .   ? -16.714 -70.037 -27.596 0.44 95.47  ? 1005 DMS A C1  1 
HETATM 4675 C  C2  . DMS F 4 .   ? -14.202 -69.369 -28.241 0.44 99.33  ? 1005 DMS A C2  1 
HETATM 4676 P  P   . PO4 G 5 .   ? -3.860  -39.306 -23.906 1.00 68.66  ? 1006 PO4 A P   1 
HETATM 4677 O  O1  . PO4 G 5 .   ? -2.485  -40.072 -23.362 1.00 41.95  ? 1006 PO4 A O1  1 
HETATM 4678 O  O2  . PO4 G 5 .   ? -3.526  -37.874 -24.588 1.00 37.66  ? 1006 PO4 A O2  1 
HETATM 4679 O  O3  . PO4 G 5 .   ? -4.654  -40.164 -24.980 1.00 46.07  ? 1006 PO4 A O3  1 
HETATM 4680 O  O4  . PO4 G 5 .   ? -4.703  -39.158 -22.709 1.00 48.85  ? 1006 PO4 A O4  1 
HETATM 4681 P  P   . PO4 H 5 .   ? -17.325 -9.797  -28.955 0.50 185.43 ? 1007 PO4 A P   1 
HETATM 4682 O  O1  . PO4 H 5 .   ? -16.874 -9.974  -27.509 0.50 175.95 ? 1007 PO4 A O1  1 
HETATM 4683 O  O2  . PO4 H 5 .   ? -16.120 -9.924  -29.882 0.50 179.77 ? 1007 PO4 A O2  1 
HETATM 4684 O  O3  . PO4 H 5 .   ? -18.349 -10.871 -29.305 0.50 184.53 ? 1007 PO4 A O3  1 
HETATM 4685 O  O4  . PO4 H 5 .   ? -17.954 -8.419  -29.126 0.50 185.07 ? 1007 PO4 A O4  1 
HETATM 4686 C  C1  . PEG I 6 .   ? -15.956 -43.575 -41.637 0.50 56.40  ? 1008 PEG A C1  1 
HETATM 4687 O  O1  . PEG I 6 .   ? -17.160 -43.958 -41.009 0.50 54.76  ? 1008 PEG A O1  1 
HETATM 4688 C  C2  . PEG I 6 .   ? -15.810 -44.187 -42.993 0.50 59.47  ? 1008 PEG A C2  1 
HETATM 4689 O  O2  . PEG I 6 .   ? -16.076 -45.584 -42.921 0.50 61.61  ? 1008 PEG A O2  1 
HETATM 4690 C  C3  . PEG I 6 .   ? -16.142 -46.199 -44.203 0.50 61.92  ? 1008 PEG A C3  1 
HETATM 4691 C  C4  . PEG I 6 .   ? -15.070 -47.240 -44.323 0.50 61.62  ? 1008 PEG A C4  1 
HETATM 4692 O  O4  . PEG I 6 .   ? -15.598 -48.533 -44.549 0.50 60.12  ? 1008 PEG A O4  1 
HETATM 4693 CL CL  . CL  J 7 .   ? 4.293   -48.833 -29.861 1.00 44.19  ? 1009 CL  A CL  1 
HETATM 4694 C  C10 . JGP K 8 .   ? -3.261  -70.881 -20.410 0.44 64.70  ? 1010 JGP A C10 1 
HETATM 4695 C  C13 . JGP K 8 .   ? -3.767  -67.893 -20.657 0.44 65.92  ? 1010 JGP A C13 1 
HETATM 4696 C  C15 . JGP K 8 .   ? -4.890  -69.571 -19.008 0.44 66.45  ? 1010 JGP A C15 1 
HETATM 4697 C  C17 . JGP K 8 .   ? -11.417 -70.165 -20.014 0.44 60.11  ? 1010 JGP A C17 1 
HETATM 4698 C  C01 . JGP K 8 .   ? -7.368  -71.725 -18.644 0.44 64.17  ? 1010 JGP A C01 1 
HETATM 4699 C  C02 . JGP K 8 .   ? -8.670  -71.595 -18.193 0.44 63.39  ? 1010 JGP A C02 1 
HETATM 4700 C  C03 . JGP K 8 .   ? -9.594  -71.017 -19.041 0.44 62.31  ? 1010 JGP A C03 1 
HETATM 4701 C  C04 . JGP K 8 .   ? -9.240  -70.582 -20.291 0.44 59.23  ? 1010 JGP A C04 1 
HETATM 4702 C  C05 . JGP K 8 .   ? -7.951  -70.705 -20.755 0.44 61.83  ? 1010 JGP A C05 1 
HETATM 4703 C  C06 . JGP K 8 .   ? -6.998  -71.285 -19.920 0.44 63.51  ? 1010 JGP A C06 1 
HETATM 4704 C  C07 . JGP K 8 .   ? -5.599  -71.485 -20.401 0.44 65.97  ? 1010 JGP A C07 1 
HETATM 4705 O  O08 . JGP K 8 .   ? -5.362  -72.377 -21.191 0.44 67.08  ? 1010 JGP A O08 1 
HETATM 4706 N  N09 . JGP K 8 .   ? -4.637  -70.669 -19.947 0.44 66.37  ? 1010 JGP A N09 1 
HETATM 4707 C  C11 . JGP K 8 .   ? -2.885  -70.065 -21.631 0.44 64.48  ? 1010 JGP A C11 1 
HETATM 4708 C  C12 . JGP K 8 .   ? -2.626  -68.619 -21.322 0.44 65.18  ? 1010 JGP A C12 1 
HETATM 4709 C  C14 . JGP K 8 .   ? -4.075  -68.303 -19.230 0.44 69.05  ? 1010 JGP A C14 1 
HETATM 4710 O  O16 . JGP K 8 .   ? -10.330 -70.044 -20.934 0.44 59.17  ? 1010 JGP A O16 1 
HETATM 4711 O  O18 . JGP K 8 .   ? -10.932 -70.784 -18.820 0.44 57.45  ? 1010 JGP A O18 1 
HETATM 4712 O  O   . HOH L 9 .   ? -33.870 -20.164 -23.059 0.50 43.53  ? 1101 HOH A O   1 
HETATM 4713 O  O   . HOH L 9 .   ? -32.717 -51.860 -27.234 1.00 51.12  ? 1102 HOH A O   1 
HETATM 4714 O  O   . HOH L 9 .   ? -23.525 -64.574 -38.756 1.00 53.40  ? 1103 HOH A O   1 
HETATM 4715 O  O   . HOH L 9 .   ? -30.930 -60.789 -32.648 0.50 65.27  ? 1104 HOH A O   1 
HETATM 4716 O  O   . HOH L 9 .   ? 6.944   -35.313 -43.507 1.00 55.82  ? 1105 HOH A O   1 
HETATM 4717 O  O   . HOH L 9 .   ? -28.559 -69.736 -13.929 1.00 59.62  ? 1106 HOH A O   1 
HETATM 4718 O  O   . HOH L 9 .   ? -12.517 -21.810 -41.604 1.00 55.44  ? 1107 HOH A O   1 
HETATM 4719 O  O   . HOH L 9 .   ? -27.398 -65.345 -39.893 1.00 58.74  ? 1108 HOH A O   1 
HETATM 4720 O  O   . HOH L 9 .   ? -33.343 -47.388 -4.690  1.00 46.03  ? 1109 HOH A O   1 
HETATM 4721 O  O   . HOH L 9 .   ? -28.726 -62.600 -25.192 1.00 40.31  ? 1110 HOH A O   1 
HETATM 4722 O  O   . HOH L 9 .   ? -4.604  -15.406 -28.446 1.00 44.19  ? 1111 HOH A O   1 
HETATM 4723 O  O   . HOH L 9 .   ? -10.815 -48.039 -39.171 1.00 35.33  ? 1112 HOH A O   1 
HETATM 4724 O  O   . HOH L 9 .   ? 1.739   -32.406 -38.950 1.00 33.65  ? 1113 HOH A O   1 
HETATM 4725 O  O   . HOH L 9 .   ? -3.466  -15.055 -20.789 1.00 52.70  ? 1114 HOH A O   1 
HETATM 4726 O  O   . HOH L 9 .   ? -32.670 -63.176 -14.981 1.00 36.92  ? 1115 HOH A O   1 
HETATM 4727 O  O   . HOH L 9 .   ? -13.652 -74.025 -13.984 1.00 49.77  ? 1116 HOH A O   1 
HETATM 4728 O  O   . HOH L 9 .   ? -32.165 -60.287 -18.976 1.00 54.88  ? 1117 HOH A O   1 
HETATM 4729 O  O   . HOH L 9 .   ? -13.093 -12.812 -27.890 1.00 57.10  ? 1118 HOH A O   1 
HETATM 4730 O  O   . HOH L 9 .   ? -8.296  -26.428 -44.178 0.50 96.73  ? 1119 HOH A O   1 
HETATM 4731 O  O   . HOH L 9 .   ? -13.923 -49.937 -30.906 0.34 33.58  ? 1120 HOH A O   1 
HETATM 4732 O  O   . HOH L 9 .   ? -7.667  -42.604 -42.926 1.00 50.37  ? 1121 HOH A O   1 
HETATM 4733 O  O   . HOH L 9 .   ? -4.277  -53.628 -28.118 1.00 38.66  ? 1122 HOH A O   1 
HETATM 4734 O  O   . HOH L 9 .   ? -15.963 -22.570 -18.608 0.50 49.09  ? 1123 HOH A O   1 
HETATM 4735 O  O   . HOH L 9 .   ? -22.331 -27.268 -19.333 1.00 59.56  ? 1124 HOH A O   1 
HETATM 4736 O  O   . HOH L 9 .   ? -38.091 -67.280 -8.377  1.00 51.72  ? 1125 HOH A O   1 
HETATM 4737 O  O   . HOH L 9 .   ? -7.645  -48.552 0.964   0.44 32.39  ? 1126 HOH A O   1 
HETATM 4738 O  O   . HOH L 9 .   ? -39.976 -61.075 -11.240 1.00 35.94  ? 1127 HOH A O   1 
HETATM 4739 O  O   . HOH L 9 .   ? -38.056 -61.051 -14.313 1.00 42.84  ? 1128 HOH A O   1 
HETATM 4740 O  O   . HOH L 9 .   ? -31.729 -57.191 -21.730 1.00 53.34  ? 1129 HOH A O   1 
HETATM 4741 O  O   . HOH L 9 .   ? -6.728  -20.145 -27.184 1.00 43.40  ? 1130 HOH A O   1 
HETATM 4742 O  O   . HOH L 9 .   ? -40.136 -57.434 -6.424  1.00 57.73  ? 1131 HOH A O   1 
HETATM 4743 O  O   . HOH L 9 .   ? 1.357   -21.640 -45.481 1.00 57.20  ? 1132 HOH A O   1 
HETATM 4744 O  O   . HOH L 9 .   ? -20.796 -47.139 -10.203 1.00 51.08  ? 1133 HOH A O   1 
HETATM 4745 O  O   . HOH L 9 .   ? -5.207  -58.226 -29.683 0.44 39.12  ? 1134 HOH A O   1 
HETATM 4746 O  O   . HOH L 9 .   ? -19.158 -27.289 -40.243 1.00 36.18  ? 1135 HOH A O   1 
HETATM 4747 O  O   . HOH L 9 .   ? -14.583 -44.538 3.649   0.44 64.02  ? 1136 HOH A O   1 
HETATM 4748 O  O   . HOH L 9 .   ? -13.812 -20.576 -16.859 0.50 28.82  ? 1137 HOH A O   1 
HETATM 4749 O  O   . HOH L 9 .   ? -21.492 -65.835 -4.508  1.00 56.99  ? 1138 HOH A O   1 
HETATM 4750 O  O   . HOH L 9 .   ? -5.378  -60.071 -0.796  1.00 47.20  ? 1139 HOH A O   1 
HETATM 4751 O  O   . HOH L 9 .   ? -8.830  -63.655 -31.017 1.00 49.40  ? 1140 HOH A O   1 
HETATM 4752 O  O   . HOH L 9 .   ? -4.249  -65.350 -14.940 1.00 41.95  ? 1141 HOH A O   1 
HETATM 4753 O  O   . HOH L 9 .   ? 0.089   -30.972 -23.207 1.00 34.32  ? 1142 HOH A O   1 
HETATM 4754 O  O   . HOH L 9 .   ? -12.842 -53.272 -40.607 1.00 57.91  ? 1143 HOH A O   1 
HETATM 4755 O  O   . HOH L 9 .   ? -39.324 -55.223 -6.399  1.00 46.57  ? 1144 HOH A O   1 
HETATM 4756 O  O   . HOH L 9 .   ? -14.454 -17.301 -35.888 0.50 44.87  ? 1145 HOH A O   1 
HETATM 4757 O  O   . HOH L 9 .   ? -4.294  -54.004 -11.975 1.00 52.81  ? 1146 HOH A O   1 
HETATM 4758 O  O   . HOH L 9 .   ? -8.931  -58.790 -13.304 1.00 28.50  ? 1147 HOH A O   1 
HETATM 4759 O  O   . HOH L 9 .   ? -10.885 -62.112 -18.709 1.00 25.58  ? 1148 HOH A O   1 
HETATM 4760 O  O   . HOH L 9 .   ? 0.360   -32.774 -27.927 1.00 30.71  ? 1149 HOH A O   1 
HETATM 4761 O  O   . HOH L 9 .   ? -24.285 -68.989 -27.777 1.00 51.03  ? 1150 HOH A O   1 
HETATM 4762 O  O   . HOH L 9 .   ? -15.126 -54.160 -39.742 1.00 42.11  ? 1151 HOH A O   1 
HETATM 4763 O  O   . HOH L 9 .   ? -26.226 -71.132 -3.526  1.00 55.25  ? 1152 HOH A O   1 
HETATM 4764 O  O   . HOH L 9 .   ? -8.375  -64.595 -6.941  1.00 42.42  ? 1153 HOH A O   1 
HETATM 4765 O  O   . HOH L 9 .   ? -34.614 -62.629 0.616   1.00 30.90  ? 1154 HOH A O   1 
HETATM 4766 O  O   . HOH L 9 .   ? -17.663 -65.506 -36.187 1.00 49.66  ? 1155 HOH A O   1 
HETATM 4767 O  O   . HOH L 9 .   ? -20.610 -29.191 -25.240 1.00 54.20  ? 1156 HOH A O   1 
HETATM 4768 O  O   . HOH L 9 .   ? 11.483  -34.603 -33.123 1.00 43.22  ? 1157 HOH A O   1 
HETATM 4769 O  O   . HOH L 9 .   ? -3.769  -61.254 -15.405 1.00 35.12  ? 1158 HOH A O   1 
HETATM 4770 O  O   . HOH L 9 .   ? -26.319 -25.412 -33.563 1.00 31.12  ? 1159 HOH A O   1 
HETATM 4771 O  O   . HOH L 9 .   ? -30.035 -56.418 -34.315 1.00 52.34  ? 1160 HOH A O   1 
HETATM 4772 O  O   . HOH L 9 .   ? -17.919 -61.962 -3.041  1.00 29.03  ? 1161 HOH A O   1 
HETATM 4773 O  O   . HOH L 9 .   ? -39.711 -23.971 -26.710 1.00 55.26  ? 1162 HOH A O   1 
HETATM 4774 O  O   . HOH L 9 .   ? -38.690 -60.719 -4.302  1.00 46.26  ? 1163 HOH A O   1 
HETATM 4775 O  O   . HOH L 9 .   ? -31.663 -60.009 -15.791 1.00 34.56  ? 1164 HOH A O   1 
HETATM 4776 O  O   . HOH L 9 .   ? 3.898   -37.586 -44.250 1.00 52.46  ? 1165 HOH A O   1 
HETATM 4777 O  O   . HOH L 9 .   ? -27.407 -51.938 -41.715 1.00 57.37  ? 1166 HOH A O   1 
HETATM 4778 O  O   . HOH L 9 .   ? 7.653   -49.207 -31.032 1.00 62.57  ? 1167 HOH A O   1 
HETATM 4779 O  O   . HOH L 9 .   ? -28.249 -49.725 0.174   1.00 43.92  ? 1168 HOH A O   1 
HETATM 4780 O  O   . HOH L 9 .   ? -7.271  -47.160 -18.185 1.00 38.34  ? 1169 HOH A O   1 
HETATM 4781 O  O   . HOH L 9 .   ? -19.351 -16.952 -11.162 1.00 51.14  ? 1170 HOH A O   1 
HETATM 4782 O  O   . HOH L 9 .   ? 4.529   -26.734 -29.562 1.00 38.29  ? 1171 HOH A O   1 
HETATM 4783 O  O   . HOH L 9 .   ? -36.794 -49.989 -5.160  1.00 40.81  ? 1172 HOH A O   1 
HETATM 4784 O  O   . HOH L 9 .   ? -18.981 -69.485 -8.242  1.00 28.31  ? 1173 HOH A O   1 
HETATM 4785 O  O   . HOH L 9 .   ? -33.329 -57.222 -19.529 1.00 55.44  ? 1174 HOH A O   1 
HETATM 4786 O  O   . HOH L 9 .   ? -22.090 -74.004 -11.683 1.00 38.45  ? 1175 HOH A O   1 
HETATM 4787 O  O   . HOH L 9 .   ? -32.526 -14.136 -9.749  0.50 36.24  ? 1176 HOH A O   1 
HETATM 4788 O  O   . HOH L 9 .   ? -12.356 -57.979 0.000   0.50 29.26  ? 1177 HOH A O   1 
HETATM 4789 O  O   . HOH L 9 .   ? 5.994   -32.839 -37.833 1.00 50.81  ? 1178 HOH A O   1 
HETATM 4790 O  O   . HOH L 9 .   ? -35.459 -66.501 -0.787  1.00 47.06  ? 1179 HOH A O   1 
HETATM 4791 O  O   . HOH L 9 .   ? -27.567 -22.712 -26.863 1.00 37.28  ? 1180 HOH A O   1 
HETATM 4792 O  O   . HOH L 9 .   ? -13.964 -52.060 -5.840  1.00 29.93  ? 1181 HOH A O   1 
HETATM 4793 O  O   . HOH L 9 .   ? -5.240  -48.479 -28.651 1.00 36.81  ? 1182 HOH A O   1 
HETATM 4794 O  O   . HOH L 9 .   ? -14.779 -34.645 -29.143 1.00 26.99  ? 1183 HOH A O   1 
HETATM 4795 O  O   . HOH L 9 .   ? 5.043   -16.424 -21.693 1.00 57.51  ? 1184 HOH A O   1 
HETATM 4796 O  O   . HOH L 9 .   ? -14.484 -63.789 -0.474  1.00 30.62  ? 1185 HOH A O   1 
HETATM 4797 O  O   . HOH L 9 .   ? 4.355   -29.012 -44.378 1.00 46.14  ? 1186 HOH A O   1 
HETATM 4798 O  O   . HOH L 9 .   ? 2.834   -39.357 -27.046 1.00 33.49  ? 1187 HOH A O   1 
HETATM 4799 O  O   . HOH L 9 .   ? -11.653 -40.166 -39.149 0.50 41.12  ? 1188 HOH A O   1 
HETATM 4800 O  O   . HOH L 9 .   ? -18.738 -65.054 -7.142  1.00 27.51  ? 1189 HOH A O   1 
HETATM 4801 O  O   . HOH L 9 .   ? -18.969 -47.729 1.867   1.00 48.72  ? 1190 HOH A O   1 
HETATM 4802 O  O   . HOH L 9 .   ? 5.614   -30.019 -21.613 1.00 34.49  ? 1191 HOH A O   1 
HETATM 4803 O  O   . HOH L 9 .   ? -12.482 -42.858 -39.312 0.50 29.58  ? 1192 HOH A O   1 
HETATM 4804 O  O   . HOH L 9 .   ? -17.392 -31.013 -41.837 1.00 56.65  ? 1193 HOH A O   1 
HETATM 4805 O  O   . HOH L 9 .   ? -3.490  -60.178 -31.867 0.44 43.44  ? 1194 HOH A O   1 
HETATM 4806 O  O   . HOH L 9 .   ? -15.354 -26.922 -46.135 1.00 56.44  ? 1195 HOH A O   1 
HETATM 4807 O  O   . HOH L 9 .   ? -22.511 -52.611 -46.567 1.00 54.01  ? 1196 HOH A O   1 
HETATM 4808 O  O   . HOH L 9 .   ? -22.384 -65.476 -23.790 1.00 44.09  ? 1197 HOH A O   1 
HETATM 4809 O  O   . HOH L 9 .   ? 8.216   -21.568 -25.589 0.50 34.65  ? 1198 HOH A O   1 
HETATM 4810 O  O   . HOH L 9 .   ? -15.500 -65.560 -33.740 1.00 54.50  ? 1199 HOH A O   1 
HETATM 4811 O  O   . HOH L 9 .   ? -24.781 -23.564 -42.541 0.50 43.92  ? 1200 HOH A O   1 
HETATM 4812 O  O   . HOH L 9 .   ? -35.067 -57.178 -29.034 0.50 51.11  ? 1201 HOH A O   1 
HETATM 4813 O  O   . HOH L 9 .   ? -5.294  -58.320 -36.430 0.44 39.36  ? 1202 HOH A O   1 
HETATM 4814 O  O   . HOH L 9 .   ? -4.095  -73.026 -15.307 0.44 39.44  ? 1203 HOH A O   1 
HETATM 4815 O  O   . HOH L 9 .   ? -40.965 -57.979 -9.919  0.50 37.88  ? 1204 HOH A O   1 
HETATM 4816 O  O   . HOH L 9 .   ? -7.514  -57.326 -1.156  1.00 53.12  ? 1205 HOH A O   1 
HETATM 4817 O  O   . HOH L 9 .   ? -9.847  -63.807 -33.086 1.00 51.54  ? 1206 HOH A O   1 
HETATM 4818 O  O   . HOH L 9 .   ? 6.163   -31.143 -19.401 1.00 45.81  ? 1207 HOH A O   1 
HETATM 4819 O  O   . HOH L 9 .   ? -8.829  -36.874 -19.723 1.00 58.09  ? 1208 HOH A O   1 
HETATM 4820 O  O   . HOH L 9 .   ? 10.653  -26.824 -29.316 1.00 39.43  ? 1209 HOH A O   1 
HETATM 4821 O  O   . HOH L 9 .   ? -22.602 -20.744 -38.216 1.00 48.33  ? 1210 HOH A O   1 
HETATM 4822 O  O   . HOH L 9 .   ? -22.364 -50.837 -9.027  1.00 35.11  ? 1211 HOH A O   1 
HETATM 4823 O  O   . HOH L 9 .   ? -19.097 -20.511 -40.439 1.00 54.10  ? 1212 HOH A O   1 
HETATM 4824 O  O   . HOH L 9 .   ? -3.990  -22.934 -25.267 1.00 44.12  ? 1213 HOH A O   1 
HETATM 4825 O  O   . HOH L 9 .   ? -9.151  -21.252 -27.213 1.00 39.08  ? 1214 HOH A O   1 
HETATM 4826 O  O   . HOH L 9 .   ? -20.519 -31.378 -29.348 1.00 34.62  ? 1215 HOH A O   1 
HETATM 4827 O  O   . HOH L 9 .   ? -3.886  -57.359 -9.692  1.00 41.38  ? 1216 HOH A O   1 
HETATM 4828 O  O   . HOH L 9 .   ? -19.772 -37.891 -36.563 1.00 37.96  ? 1217 HOH A O   1 
HETATM 4829 O  O   . HOH L 9 .   ? -5.457  -58.952 -11.993 1.00 48.96  ? 1218 HOH A O   1 
HETATM 4830 O  O   . HOH L 9 .   ? -30.007 -60.511 -23.144 1.00 38.40  ? 1219 HOH A O   1 
HETATM 4831 O  O   . HOH L 9 .   ? -12.153 -36.852 -39.707 1.00 41.00  ? 1220 HOH A O   1 
HETATM 4832 O  O   . HOH L 9 .   ? -3.167  -54.991 -17.976 1.00 33.40  ? 1221 HOH A O   1 
HETATM 4833 O  O   . HOH L 9 .   ? -21.165 -41.278 -35.782 0.50 28.16  ? 1222 HOH A O   1 
HETATM 4834 O  O   . HOH L 9 .   ? -22.716 -33.373 -37.040 1.00 36.23  ? 1223 HOH A O   1 
HETATM 4835 O  O   . HOH L 9 .   ? 1.127   -41.616 -24.640 1.00 45.31  ? 1224 HOH A O   1 
HETATM 4836 O  O   . HOH L 9 .   ? -5.972  -68.249 -27.531 1.00 41.44  ? 1225 HOH A O   1 
HETATM 4837 O  O   . HOH L 9 .   ? -24.927 -53.238 -1.862  1.00 31.24  ? 1226 HOH A O   1 
HETATM 4838 O  O   . HOH L 9 .   ? -20.595 -66.022 -1.145  1.00 45.61  ? 1227 HOH A O   1 
HETATM 4839 O  O   . HOH L 9 .   ? 5.937   -40.250 -21.140 1.00 68.33  ? 1228 HOH A O   1 
HETATM 4840 O  O   . HOH L 9 .   ? -16.938 -51.731 -15.512 1.00 22.62  ? 1229 HOH A O   1 
HETATM 4841 O  O   . HOH L 9 .   ? -38.790 -56.795 -20.310 1.00 54.26  ? 1230 HOH A O   1 
HETATM 4842 O  O   . HOH L 9 .   ? -18.172 -69.149 -25.022 1.00 40.19  ? 1231 HOH A O   1 
HETATM 4843 O  O   . HOH L 9 .   ? 10.944  -38.963 -29.541 1.00 58.67  ? 1232 HOH A O   1 
HETATM 4844 O  O   . HOH L 9 .   ? -25.329 -20.222 -5.150  1.00 57.28  ? 1233 HOH A O   1 
HETATM 4845 O  O   . HOH L 9 .   ? -13.191 -68.480 -6.072  1.00 46.50  ? 1234 HOH A O   1 
HETATM 4846 O  O   . HOH L 9 .   ? -14.723 -54.078 -4.076  1.00 30.02  ? 1235 HOH A O   1 
HETATM 4847 O  O   . HOH L 9 .   ? -35.518 -58.445 -27.136 1.00 56.03  ? 1236 HOH A O   1 
HETATM 4848 O  O   . HOH L 9 .   ? 5.667   -38.588 -24.410 1.00 52.87  ? 1237 HOH A O   1 
HETATM 4849 O  O   . HOH L 9 .   ? -14.146 -56.237 -1.533  1.00 26.93  ? 1238 HOH A O   1 
HETATM 4850 O  O   . HOH L 9 .   ? -20.036 -46.354 -25.551 0.38 23.13  ? 1239 HOH A O   1 
HETATM 4851 O  O   . HOH L 9 .   ? -5.722  -50.154 -18.964 1.00 37.88  ? 1240 HOH A O   1 
HETATM 4852 O  O   . HOH L 9 .   ? -17.926 -41.665 -37.182 0.50 70.39  ? 1241 HOH A O   1 
HETATM 4853 O  O   . HOH L 9 .   ? -0.309  -35.657 -28.238 1.00 38.98  ? 1242 HOH A O   1 
HETATM 4854 O  O   . HOH L 9 .   ? -3.997  -56.749 -13.333 1.00 45.39  ? 1243 HOH A O   1 
HETATM 4855 O  O   . HOH L 9 .   ? -3.317  -51.570 2.192   0.44 57.83  ? 1244 HOH A O   1 
HETATM 4856 O  O   . HOH L 9 .   ? -13.629 -53.442 -1.522  1.00 31.86  ? 1245 HOH A O   1 
HETATM 4857 O  O   . HOH L 9 .   ? 2.798   -64.356 -20.667 1.00 25.45  ? 1246 HOH A O   1 
HETATM 4858 O  O   . HOH L 9 .   ? -33.055 -46.802 -15.614 0.50 46.69  ? 1247 HOH A O   1 
HETATM 4859 O  O   . HOH L 9 .   ? -5.688  -48.857 -21.311 1.00 31.63  ? 1248 HOH A O   1 
HETATM 4860 O  O   . HOH L 9 .   ? 0.551   -70.392 -21.119 0.44 50.84  ? 1249 HOH A O   1 
HETATM 4861 O  O   . HOH L 9 .   ? -6.257  -42.813 -21.184 0.50 25.71  ? 1250 HOH A O   1 
HETATM 4862 O  O   . HOH L 9 .   ? -13.523 -51.042 -43.107 1.00 67.53  ? 1251 HOH A O   1 
HETATM 4863 O  O   . HOH L 9 .   ? -14.939 -48.480 -18.561 1.00 43.02  ? 1252 HOH A O   1 
HETATM 4864 O  O   . HOH L 9 .   ? -4.858  -56.320 -31.686 1.00 30.91  ? 1253 HOH A O   1 
HETATM 4865 O  O   . HOH L 9 .   ? -39.314 -65.151 -2.012  0.50 40.17  ? 1254 HOH A O   1 
HETATM 4866 O  O   . HOH L 9 .   ? -20.478 -67.157 -25.304 1.00 36.19  ? 1255 HOH A O   1 
HETATM 4867 O  O   . HOH L 9 .   ? -4.724  -52.662 -38.928 1.00 59.56  ? 1256 HOH A O   1 
HETATM 4868 O  O   . HOH L 9 .   ? -22.747 -75.103 -9.303  1.00 47.72  ? 1257 HOH A O   1 
HETATM 4869 O  O   . HOH L 9 .   ? -35.750 -54.036 -3.288  1.00 40.23  ? 1258 HOH A O   1 
HETATM 4870 O  O   . HOH L 9 .   ? -27.565 -16.608 -32.849 1.00 38.13  ? 1259 HOH A O   1 
HETATM 4871 O  O   . HOH L 9 .   ? -37.380 -52.303 -12.923 1.00 37.13  ? 1260 HOH A O   1 
HETATM 4872 O  O   . HOH L 9 .   ? -17.196 -28.950 -41.277 1.00 54.11  ? 1261 HOH A O   1 
HETATM 4873 O  O   . HOH L 9 .   ? -28.654 -36.889 -30.771 0.50 44.50  ? 1262 HOH A O   1 
HETATM 4874 O  O   . HOH L 9 .   ? 0.061   -48.222 -36.231 1.00 44.95  ? 1263 HOH A O   1 
HETATM 4875 O  O   . HOH L 9 .   ? -21.778 -31.491 -39.709 1.00 55.14  ? 1264 HOH A O   1 
HETATM 4876 O  O   . HOH L 9 .   ? -12.385 -66.665 -29.727 1.00 41.28  ? 1265 HOH A O   1 
HETATM 4877 O  O   . HOH L 9 .   ? -42.495 -62.507 -5.011  1.00 59.42  ? 1266 HOH A O   1 
HETATM 4878 O  O   . HOH L 9 .   ? -27.032 -15.187 -20.166 1.00 47.31  ? 1267 HOH A O   1 
HETATM 4879 O  O   . HOH L 9 .   ? -2.520  -57.664 -27.457 1.00 33.12  ? 1268 HOH A O   1 
HETATM 4880 O  O   . HOH L 9 .   ? -8.112  -16.736 -39.494 1.00 53.83  ? 1269 HOH A O   1 
HETATM 4881 O  O   . HOH L 9 .   ? -23.517 -49.147 -41.938 1.00 49.47  ? 1270 HOH A O   1 
HETATM 4882 O  O   . HOH L 9 .   ? 8.746   -40.528 -31.592 1.00 51.58  ? 1271 HOH A O   1 
HETATM 4883 O  O   . HOH L 9 .   ? -22.997 -29.316 -16.577 0.50 45.10  ? 1272 HOH A O   1 
HETATM 4884 O  O   . HOH L 9 .   ? -8.944  -70.850 -14.775 1.00 39.81  ? 1273 HOH A O   1 
HETATM 4885 O  O   . HOH L 9 .   ? -10.167 -59.805 -43.017 0.50 37.88  ? 1274 HOH A O   1 
HETATM 4886 O  O   . HOH L 9 .   ? -26.559 -50.987 -1.881  1.00 54.41  ? 1275 HOH A O   1 
HETATM 4887 O  O   . HOH L 9 .   ? 10.077  -45.478 -31.827 0.46 35.89  ? 1276 HOH A O   1 
HETATM 4888 O  O   . HOH L 9 .   ? 3.703   -31.477 -37.387 1.00 34.21  ? 1277 HOH A O   1 
HETATM 4889 O  O   . HOH L 9 .   ? -4.421  -62.185 -4.819  1.00 46.95  ? 1278 HOH A O   1 
HETATM 4890 O  O   . HOH L 9 .   ? 10.789  -29.521 -34.351 1.00 48.04  ? 1279 HOH A O   1 
HETATM 4891 O  O   . HOH L 9 .   ? -0.910  -69.161 -16.802 0.44 34.57  ? 1280 HOH A O   1 
HETATM 4892 O  O   . HOH L 9 .   ? -29.711 -62.571 -34.405 0.50 51.98  ? 1281 HOH A O   1 
HETATM 4893 O  O   . HOH L 9 .   ? -20.849 -48.977 -34.885 1.00 59.15  ? 1282 HOH A O   1 
HETATM 4894 O  O   . HOH L 9 .   ? -22.503 -37.440 -37.338 1.00 61.25  ? 1283 HOH A O   1 
HETATM 4895 O  O   . HOH L 9 .   ? -12.660 -46.304 3.697   0.44 50.38  ? 1284 HOH A O   1 
HETATM 4896 O  O   . HOH L 9 .   ? -7.487  -30.101 -46.265 1.00 50.93  ? 1285 HOH A O   1 
HETATM 4897 O  O   . HOH L 9 .   ? -34.068 -69.906 -18.425 1.00 45.13  ? 1286 HOH A O   1 
HETATM 4898 O  O   . HOH L 9 .   ? -6.503  -74.191 -13.370 1.00 63.31  ? 1287 HOH A O   1 
HETATM 4899 O  O   . HOH L 9 .   ? -23.081 -48.617 -34.207 0.50 52.83  ? 1288 HOH A O   1 
HETATM 4900 O  O   . HOH L 9 .   ? -26.027 -29.954 -23.263 1.00 53.76  ? 1289 HOH A O   1 
HETATM 4901 O  O   . HOH L 9 .   ? -2.985  -19.892 -23.945 1.00 50.65  ? 1290 HOH A O   1 
HETATM 4902 O  O   . HOH L 9 .   ? -38.767 -54.742 -19.106 1.00 49.42  ? 1291 HOH A O   1 
HETATM 4903 O  O   . HOH L 9 .   ? 13.632  -30.333 -19.773 1.00 48.58  ? 1292 HOH A O   1 
HETATM 4904 O  O   . HOH L 9 .   ? 10.344  -25.687 -32.934 1.00 58.55  ? 1293 HOH A O   1 
HETATM 4905 O  O   . HOH L 9 .   ? -17.201 -57.108 -43.864 1.00 37.56  ? 1294 HOH A O   1 
HETATM 4906 O  O   . HOH L 9 .   ? 9.960   -24.728 -36.855 0.50 44.37  ? 1295 HOH A O   1 
HETATM 4907 O  O   . HOH L 9 .   ? -8.030  -62.110 -33.656 1.00 54.28  ? 1296 HOH A O   1 
HETATM 4908 O  O   . HOH L 9 .   ? 3.534   -33.730 -14.311 1.00 51.29  ? 1297 HOH A O   1 
HETATM 4909 O  O   . HOH L 9 .   ? -14.856 -56.703 -41.884 1.00 39.88  ? 1298 HOH A O   1 
HETATM 4910 O  O   . HOH L 9 .   ? -19.240 -64.392 -2.909  1.00 49.47  ? 1299 HOH A O   1 
HETATM 4911 O  O   . HOH L 9 .   ? 1.235   -38.367 -21.157 1.00 56.00  ? 1300 HOH A O   1 
HETATM 4912 O  O   . HOH L 9 .   ? -0.712  -32.339 -25.485 1.00 32.03  ? 1301 HOH A O   1 
HETATM 4913 O  O   . HOH L 9 .   ? -22.298 -43.944 -33.354 0.34 36.59  ? 1302 HOH A O   1 
HETATM 4914 O  O   . HOH L 9 .   ? 9.213   -24.031 -44.561 0.50 49.48  ? 1303 HOH A O   1 
HETATM 4915 O  O   . HOH L 9 .   ? -15.506 -54.461 -44.206 1.00 61.45  ? 1304 HOH A O   1 
HETATM 4916 O  O   . HOH L 9 .   ? -29.696 -59.264 -19.818 1.00 38.76  ? 1305 HOH A O   1 
HETATM 4917 O  O   . HOH L 9 .   ? -24.368 -57.637 -46.716 1.00 55.40  ? 1306 HOH A O   1 
HETATM 4918 O  O   . HOH L 9 .   ? -11.764 -40.796 -19.929 1.00 59.99  ? 1307 HOH A O   1 
HETATM 4919 O  O   . HOH L 9 .   ? -3.738  -56.442 -7.102  1.00 35.31  ? 1308 HOH A O   1 
HETATM 4920 O  O   . HOH L 9 .   ? -0.251  -55.502 -32.930 1.00 61.18  ? 1309 HOH A O   1 
HETATM 4921 O  O   . HOH L 9 .   ? -11.641 -71.723 -15.502 1.00 29.72  ? 1310 HOH A O   1 
HETATM 4922 O  O   . HOH L 9 .   ? -30.935 -19.419 -34.777 1.00 56.87  ? 1311 HOH A O   1 
HETATM 4923 O  O   . HOH L 9 .   ? -16.844 -28.749 -14.880 1.00 57.83  ? 1312 HOH A O   1 
HETATM 4924 O  O   . HOH L 9 .   ? -31.879 -18.613 -31.361 1.00 51.44  ? 1313 HOH A O   1 
HETATM 4925 O  O   . HOH L 9 .   ? -17.384 -71.131 -22.635 1.00 52.74  ? 1314 HOH A O   1 
HETATM 4926 O  O   . HOH L 9 .   ? -35.108 -58.793 -0.301  0.50 40.04  ? 1315 HOH A O   1 
HETATM 4927 O  O   . HOH L 9 .   ? 0.682   -31.420 -47.204 1.00 54.96  ? 1316 HOH A O   1 
HETATM 4928 O  O   . HOH L 9 .   ? -9.205  -70.879 -25.966 0.44 27.63  ? 1317 HOH A O   1 
HETATM 4929 O  O   . HOH L 9 .   ? -26.900 -26.557 -35.784 1.00 37.99  ? 1318 HOH A O   1 
HETATM 4930 O  O   . HOH L 9 .   ? -25.134 -68.699 -0.190  0.44 65.73  ? 1319 HOH A O   1 
HETATM 4931 O  O   . HOH L 9 .   ? -3.589  -70.704 -9.028  1.00 40.63  ? 1320 HOH A O   1 
HETATM 4932 O  O   . HOH L 9 .   ? -2.920  -57.790 -24.548 1.00 29.03  ? 1321 HOH A O   1 
HETATM 4933 O  O   . HOH L 9 .   ? -5.758  -68.809 -7.239  1.00 38.91  ? 1322 HOH A O   1 
HETATM 4934 O  O   . HOH L 9 .   ? -26.584 -67.586 -27.954 1.00 32.32  ? 1323 HOH A O   1 
HETATM 4935 O  O   . HOH L 9 .   ? 0.107   -46.003 -43.440 1.00 64.64  ? 1324 HOH A O   1 
HETATM 4936 O  O   . HOH L 9 .   ? -12.165 -43.872 -16.360 1.00 58.95  ? 1325 HOH A O   1 
HETATM 4937 O  O   . HOH L 9 .   ? -2.395  -39.647 -45.877 1.00 46.81  ? 1326 HOH A O   1 
HETATM 4938 O  O   . HOH L 9 .   ? -12.797 -11.312 -33.062 1.00 69.28  ? 1327 HOH A O   1 
HETATM 4939 O  O   . HOH L 9 .   ? 11.599  -37.028 -18.976 1.00 46.72  ? 1328 HOH A O   1 
HETATM 4940 O  O   . HOH L 9 .   ? -9.471  -34.915 -44.488 0.50 30.79  ? 1329 HOH A O   1 
HETATM 4941 O  O   . HOH L 9 .   ? -12.969 -32.547 -20.619 1.00 37.69  ? 1330 HOH A O   1 
HETATM 4942 O  O   . HOH L 9 .   ? 12.138  -40.288 -25.253 0.44 42.12  ? 1331 HOH A O   1 
HETATM 4943 O  O   . HOH L 9 .   ? -31.002 -71.765 -13.734 1.00 64.25  ? 1332 HOH A O   1 
HETATM 4944 O  O   . HOH L 9 .   ? -22.873 -37.034 -32.725 1.00 55.77  ? 1333 HOH A O   1 
HETATM 4945 O  O   . HOH L 9 .   ? -13.852 -44.685 -10.043 1.00 63.11  ? 1334 HOH A O   1 
HETATM 4946 O  O   . HOH L 9 .   ? -8.429  -67.785 -28.457 1.00 48.73  ? 1335 HOH A O   1 
HETATM 4947 O  O   . HOH L 9 .   ? -37.819 -61.198 -0.737  1.00 68.21  ? 1336 HOH A O   1 
HETATM 4948 O  O   . HOH L 9 .   ? 4.358   -62.283 -20.081 1.00 26.97  ? 1337 HOH A O   1 
HETATM 4949 O  O   . HOH L 9 .   ? -20.243 -56.916 -48.336 1.00 65.10  ? 1338 HOH A O   1 
HETATM 4950 O  O   . HOH L 9 .   ? 2.530   -44.020 -42.366 0.50 41.27  ? 1339 HOH A O   1 
HETATM 4951 O  O   . HOH L 9 .   ? -33.894 -49.176 -10.627 0.50 37.11  ? 1340 HOH A O   1 
HETATM 4952 O  O   . HOH L 9 .   ? -13.601 -59.706 -44.650 0.50 51.41  ? 1341 HOH A O   1 
HETATM 4953 O  O   . HOH L 9 .   ? 4.867   -68.721 -21.614 1.00 32.09  ? 1342 HOH A O   1 
HETATM 4954 O  O   . HOH L 9 .   ? -26.976 -73.586 -4.843  1.00 54.45  ? 1343 HOH A O   1 
HETATM 4955 O  O   . HOH L 9 .   ? -42.113 -66.180 -9.568  1.00 65.53  ? 1344 HOH A O   1 
HETATM 4956 O  O   . HOH L 9 .   ? -11.330 -70.197 -24.631 0.44 36.75  ? 1345 HOH A O   1 
HETATM 4957 O  O   . HOH L 9 .   ? 4.919   -51.351 -31.153 0.46 46.70  ? 1346 HOH A O   1 
HETATM 4958 O  O   . HOH L 9 .   ? -2.990  -54.611 -35.696 1.00 69.94  ? 1347 HOH A O   1 
HETATM 4959 O  O   . HOH L 9 .   ? -34.925 -67.743 -5.658  1.00 60.62  ? 1348 HOH A O   1 
HETATM 4960 O  O   . HOH L 9 .   ? 0.310   -45.298 -36.768 1.00 52.54  ? 1349 HOH A O   1 
HETATM 4961 O  O   . HOH L 9 .   ? -12.337 -37.592 -22.171 1.00 53.44  ? 1350 HOH A O   1 
HETATM 4962 O  O   . HOH L 9 .   ? -2.903  -55.596 -28.972 1.00 35.99  ? 1351 HOH A O   1 
HETATM 4963 O  O   . HOH L 9 .   ? -33.852 -48.144 -24.868 0.38 48.14  ? 1352 HOH A O   1 
HETATM 4964 O  O   . HOH L 9 .   ? -12.645 -10.738 -29.688 0.50 47.10  ? 1353 HOH A O   1 
HETATM 4965 O  O   . HOH L 9 .   ? -40.753 -23.348 -18.727 1.00 69.85  ? 1354 HOH A O   1 
HETATM 4966 O  O   . HOH L 9 .   ? -37.689 -37.374 -26.153 1.00 62.02  ? 1355 HOH A O   1 
HETATM 4967 O  O   . HOH L 9 .   ? -3.421  -51.872 -4.936  1.00 55.88  ? 1356 HOH A O   1 
HETATM 4968 O  O   . HOH L 9 .   ? -14.909 -45.202 -19.410 1.00 68.18  ? 1357 HOH A O   1 
HETATM 4969 O  O   . HOH L 9 .   ? -16.209 -48.938 -16.321 1.00 29.49  ? 1358 HOH A O   1 
HETATM 4970 O  O   . HOH L 9 .   ? -13.728 -71.144 -21.950 0.44 45.67  ? 1359 HOH A O   1 
HETATM 4971 O  O   . HOH L 9 .   ? -10.083 -17.561 -40.803 1.00 53.56  ? 1360 HOH A O   1 
HETATM 4972 O  O   . HOH L 9 .   ? -34.284 -70.415 -13.917 1.00 68.78  ? 1361 HOH A O   1 
HETATM 4973 O  O   . HOH L 9 .   ? -36.817 -64.499 -0.015  1.00 51.72  ? 1362 HOH A O   1 
HETATM 4974 O  O   . HOH L 9 .   ? -15.778 -69.075 -5.984  1.00 37.25  ? 1363 HOH A O   1 
HETATM 4975 O  O   . HOH L 9 .   ? -19.878 -31.052 -26.847 1.00 35.88  ? 1364 HOH A O   1 
HETATM 4976 O  O   . HOH L 9 .   ? -17.777 -28.118 -44.491 0.50 43.00  ? 1365 HOH A O   1 
HETATM 4977 O  O   . HOH L 9 .   ? -10.547 -68.069 -38.512 0.50 38.95  ? 1366 HOH A O   1 
HETATM 4978 O  O   . HOH L 9 .   ? -20.786 -43.512 -42.269 0.50 40.07  ? 1367 HOH A O   1 
HETATM 4979 O  O   . HOH L 9 .   ? -15.624 -41.393 -38.555 1.00 55.49  ? 1368 HOH A O   1 
HETATM 4980 O  O   . HOH L 9 .   ? -36.141 -56.399 -4.195  1.00 60.63  ? 1369 HOH A O   1 
HETATM 4981 O  O   . HOH L 9 .   ? -37.865 -51.838 -3.967  1.00 51.22  ? 1370 HOH A O   1 
HETATM 4982 O  O   . HOH L 9 .   ? 0.316   -62.074 -17.487 1.00 43.52  ? 1371 HOH A O   1 
HETATM 4983 O  O   . HOH L 9 .   ? -15.088 -44.244 -5.174  1.00 66.05  ? 1372 HOH A O   1 
HETATM 4984 O  O   . HOH L 9 .   ? -15.404 -69.897 -20.053 0.44 31.42  ? 1373 HOH A O   1 
HETATM 4985 O  O   . HOH L 9 .   ? -30.402 -16.621 -32.713 1.00 55.13  ? 1374 HOH A O   1 
HETATM 4986 O  O   . HOH L 9 .   ? -7.903  -55.325 -41.759 1.00 66.80  ? 1375 HOH A O   1 
HETATM 4987 O  O   . HOH L 9 .   ? -43.528 -67.724 -17.355 0.50 43.39  ? 1376 HOH A O   1 
HETATM 4988 O  O   . HOH L 9 .   ? -40.926 -56.593 -13.691 1.00 49.78  ? 1377 HOH A O   1 
HETATM 4989 O  O   . HOH L 9 .   ? 0.000   -57.979 -28.558 0.50 36.38  ? 1378 HOH A O   1 
HETATM 4990 O  O   . HOH L 9 .   ? -4.382  -49.193 2.953   1.00 71.77  ? 1379 HOH A O   1 
HETATM 4991 O  O   . HOH L 9 .   ? -6.420  -44.793 -17.408 1.00 59.51  ? 1380 HOH A O   1 
HETATM 4992 O  O   . HOH L 9 .   ? -10.096 -38.319 -43.557 1.00 57.18  ? 1381 HOH A O   1 
HETATM 4993 O  O   . HOH L 9 .   ? -27.489 -48.664 -29.964 0.50 61.84  ? 1382 HOH A O   1 
HETATM 4994 O  O   . HOH L 9 .   ? -35.136 -47.645 -13.561 0.50 45.88  ? 1383 HOH A O   1 
HETATM 4995 O  O   . HOH L 9 .   ? -2.784  -56.359 -33.779 0.44 26.24  ? 1384 HOH A O   1 
HETATM 4996 O  O   . HOH L 9 .   ? -2.855  -60.486 -6.059  0.44 30.79  ? 1385 HOH A O   1 
HETATM 4997 O  O   . HOH L 9 .   ? 0.795   -42.633 -21.760 1.00 59.35  ? 1386 HOH A O   1 
HETATM 4998 O  O   . HOH L 9 .   ? -18.174 -67.694 -6.409  1.00 29.81  ? 1387 HOH A O   1 
HETATM 4999 O  O   . HOH L 9 .   ? -19.945 -67.970 -4.347  1.00 38.62  ? 1388 HOH A O   1 
HETATM 5000 O  O   . HOH L 9 .   ? 16.692  -34.302 -26.618 1.00 64.02  ? 1389 HOH A O   1 
HETATM 5001 O  O   . HOH L 9 .   ? -25.165 -28.978 -44.213 0.50 46.06  ? 1390 HOH A O   1 
HETATM 5002 O  O   . HOH L 9 .   ? -8.920  -34.685 -46.215 0.50 51.61  ? 1391 HOH A O   1 
HETATM 5003 O  O   . HOH L 9 .   ? -4.145  -60.270 -10.114 1.00 58.88  ? 1392 HOH A O   1 
HETATM 5004 O  O   . HOH L 9 .   ? -5.407  -63.965 -6.557  1.00 50.49  ? 1393 HOH A O   1 
HETATM 5005 O  O   . HOH L 9 .   ? 12.548  -36.846 -30.761 1.00 61.48  ? 1394 HOH A O   1 
HETATM 5006 O  O   . HOH L 9 .   ? -1.200  -62.077 -13.600 0.42 38.64  ? 1395 HOH A O   1 
HETATM 5007 O  O   . HOH L 9 .   ? -25.242 -43.590 -33.539 1.00 80.65  ? 1396 HOH A O   1 
HETATM 5008 O  O   . HOH L 9 .   ? 0.000   -57.979 -14.488 0.42 79.39  ? 1397 HOH A O   1 
HETATM 5009 O  O   . HOH L 9 .   ? -31.146 -73.304 -22.365 0.44 53.02  ? 1398 HOH A O   1 
HETATM 5010 O  O   . HOH L 9 .   ? -28.452 -55.537 -45.459 0.50 43.12  ? 1399 HOH A O   1 
HETATM 5011 O  O   . HOH L 9 .   ? 10.678  -20.508 -24.926 0.50 41.43  ? 1400 HOH A O   1 
HETATM 5012 O  O   . HOH L 9 .   ? -32.009 -18.846 -5.537  0.50 47.90  ? 1401 HOH A O   1 
HETATM 5013 O  O   . HOH L 9 .   ? -3.932  -62.350 -8.349  1.00 67.17  ? 1402 HOH A O   1 
HETATM 5014 O  O   . HOH L 9 .   ? -42.360 -61.367 -1.567  1.00 58.07  ? 1403 HOH A O   1 
# 
