data_7I2O
# 
_entry.id   7I2O 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   7I2O         pdb_00007i2o 10.2210/pdb7i2o/pdb 
WWPDB D_1001408239 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-02 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.entry_id                        7I2O 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.recvd_initial_deposition_date   2025-03-06 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.SG_entry                        ? 
_pdbx_database_status.pdb_format_compatible           Y 
_pdbx_database_status.methods_development_category    ? 
# 
_pdbx_contact_author.id                 1 
_pdbx_contact_author.email              fr193@cabm.rutgers.edu 
_pdbx_contact_author.name_first         'Francesc Xavier' 
_pdbx_contact_author.name_last          Ruiz 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0457-0030 
_pdbx_contact_author.name_mi            ? 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Aschenbrenner, J.C.' 1  ? 
'Saini, M.'           2  ? 
'Chopra, A.'          3  ? 
'Marples, P.G.'       4  ? 
'Balcomb, B.H.'       5  ? 
'Lithgo, R.M.'        6  ? 
'Fearon, D.'          7  ? 
'von Delft, F.'       8  ? 
'Ruiz, F.X.'          9  ? 
'Arnold, E.'          10 ? 
# 
_citation.id                        primary 
_citation.title                     
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_volume            ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.year                      ? 
_citation.journal_id_ASTM           ? 
_citation.country                   ? 
_citation.journal_id_ISSN           ? 
_citation.journal_id_CSD            0353 
_citation.book_publisher            ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_DOI      ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.identifier_ORCID 
_citation_author.ordinal 
primary 'Aschenbrenner, J.C.' ? 1  
primary 'Saini, M.'           ? 2  
primary 'Chopra, A.'          ? 3  
primary 'Marples, P.G.'       ? 4  
primary 'Balcomb, B.H.'       ? 5  
primary 'Lithgo, R.M.'        ? 6  
primary 'Fearon, D.'          ? 7  
primary 'von Delft, F.'       ? 8  
primary 'Ruiz, F.X.'          ? 9  
primary 'Arnold, E.'          ? 10 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'NS5 RNA-dependent RNA polymerase'                                73890.008 1   ? ? ? ? 
2 non-polymer syn 'ZINC ION'                                                        65.409    2   ? ? ? ? 
3 non-polymer syn '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                            195.237   1   ? ? ? ? 
4 non-polymer syn 'DIMETHYL SULFOXIDE'                                              78.133    3   ? ? ? ? 
5 non-polymer syn 'PHOSPHATE ION'                                                   94.971    2   ? ? ? ? 
6 non-polymer syn 'DI(HYDROXYETHYL)ETHER'                                           106.120   1   ? ? ? ? 
7 non-polymer syn '5-chloro-N-methyl-N-{[(3R)-oxolan-3-yl]methyl}pyrimidin-4-amine' 227.691   1   ? ? ? ? 
8 water       nat water                                                             18.015    323 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION'                                                        ZN  
3 '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                            MES 
4 'DIMETHYL SULFOXIDE'                                              DMS 
5 'PHOSPHATE ION'                                                   PO4 
6 'DI(HYDROXYETHYL)ETHER'                                           PEG 
7 '5-chloro-N-methyl-N-{[(3R)-oxolan-3-yl]methyl}pyrimidin-4-amine' K07 
8 water                                                             HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PRO n 
1 3   GLY n 
1 4   ILE n 
1 5   GLU n 
1 6   SER n 
1 7   GLU n 
1 8   THR n 
1 9   PRO n 
1 10  ASN n 
1 11  LEU n 
1 12  ASP n 
1 13  ILE n 
1 14  ILE n 
1 15  GLY n 
1 16  LYS n 
1 17  ARG n 
1 18  ILE n 
1 19  GLU n 
1 20  LYS n 
1 21  ILE n 
1 22  LYS n 
1 23  GLN n 
1 24  GLU n 
1 25  HIS n 
1 26  GLU n 
1 27  THR n 
1 28  SER n 
1 29  TRP n 
1 30  HIS n 
1 31  TYR n 
1 32  ASP n 
1 33  GLN n 
1 34  ASP n 
1 35  HIS n 
1 36  PRO n 
1 37  TYR n 
1 38  LYS n 
1 39  THR n 
1 40  TRP n 
1 41  ALA n 
1 42  TYR n 
1 43  HIS n 
1 44  GLY n 
1 45  SER n 
1 46  TYR n 
1 47  GLU n 
1 48  THR n 
1 49  LYS n 
1 50  GLN n 
1 51  THR n 
1 52  GLY n 
1 53  SER n 
1 54  ALA n 
1 55  SER n 
1 56  SER n 
1 57  MET n 
1 58  VAL n 
1 59  ASN n 
1 60  GLY n 
1 61  VAL n 
1 62  VAL n 
1 63  ARG n 
1 64  LEU n 
1 65  LEU n 
1 66  THR n 
1 67  LYS n 
1 68  PRO n 
1 69  TRP n 
1 70  ASP n 
1 71  ILE n 
1 72  ILE n 
1 73  PRO n 
1 74  MET n 
1 75  VAL n 
1 76  THR n 
1 77  GLN n 
1 78  MET n 
1 79  ALA n 
1 80  MET n 
1 81  THR n 
1 82  ASP n 
1 83  THR n 
1 84  THR n 
1 85  PRO n 
1 86  PHE n 
1 87  GLY n 
1 88  GLN n 
1 89  GLN n 
1 90  ARG n 
1 91  VAL n 
1 92  PHE n 
1 93  LYS n 
1 94  GLU n 
1 95  LYS n 
1 96  VAL n 
1 97  ASP n 
1 98  THR n 
1 99  ARG n 
1 100 THR n 
1 101 GLN n 
1 102 GLU n 
1 103 PRO n 
1 104 LYS n 
1 105 GLU n 
1 106 GLY n 
1 107 THR n 
1 108 LYS n 
1 109 LYS n 
1 110 LEU n 
1 111 MET n 
1 112 LYS n 
1 113 ILE n 
1 114 THR n 
1 115 ALA n 
1 116 GLU n 
1 117 TRP n 
1 118 LEU n 
1 119 TRP n 
1 120 LYS n 
1 121 GLU n 
1 122 LEU n 
1 123 GLY n 
1 124 LYS n 
1 125 LYS n 
1 126 LYS n 
1 127 THR n 
1 128 PRO n 
1 129 ARG n 
1 130 MET n 
1 131 CYS n 
1 132 THR n 
1 133 ARG n 
1 134 GLU n 
1 135 GLU n 
1 136 PHE n 
1 137 THR n 
1 138 ARG n 
1 139 LYS n 
1 140 VAL n 
1 141 ARG n 
1 142 SER n 
1 143 ASN n 
1 144 ALA n 
1 145 ALA n 
1 146 LEU n 
1 147 GLY n 
1 148 ALA n 
1 149 ILE n 
1 150 PHE n 
1 151 THR n 
1 152 ASP n 
1 153 GLU n 
1 154 ASN n 
1 155 LYS n 
1 156 TRP n 
1 157 LYS n 
1 158 SER n 
1 159 ALA n 
1 160 ARG n 
1 161 GLU n 
1 162 ALA n 
1 163 VAL n 
1 164 GLU n 
1 165 ASP n 
1 166 SER n 
1 167 GLY n 
1 168 PHE n 
1 169 TRP n 
1 170 GLU n 
1 171 LEU n 
1 172 VAL n 
1 173 ASP n 
1 174 LYS n 
1 175 GLU n 
1 176 ARG n 
1 177 ASN n 
1 178 LEU n 
1 179 HIS n 
1 180 LEU n 
1 181 GLU n 
1 182 GLY n 
1 183 LYS n 
1 184 CYS n 
1 185 GLU n 
1 186 THR n 
1 187 CYS n 
1 188 VAL n 
1 189 TYR n 
1 190 ASN n 
1 191 MET n 
1 192 MET n 
1 193 GLY n 
1 194 LYS n 
1 195 ARG n 
1 196 GLU n 
1 197 LYS n 
1 198 LYS n 
1 199 LEU n 
1 200 GLY n 
1 201 GLU n 
1 202 PHE n 
1 203 GLY n 
1 204 LYS n 
1 205 ALA n 
1 206 LYS n 
1 207 GLY n 
1 208 SER n 
1 209 ARG n 
1 210 ALA n 
1 211 ILE n 
1 212 TRP n 
1 213 TYR n 
1 214 MET n 
1 215 TRP n 
1 216 LEU n 
1 217 GLY n 
1 218 ALA n 
1 219 ARG n 
1 220 PHE n 
1 221 LEU n 
1 222 GLU n 
1 223 PHE n 
1 224 GLU n 
1 225 ALA n 
1 226 LEU n 
1 227 GLY n 
1 228 PHE n 
1 229 LEU n 
1 230 ASN n 
1 231 GLU n 
1 232 ASP n 
1 233 HIS n 
1 234 TRP n 
1 235 PHE n 
1 236 SER n 
1 237 ARG n 
1 238 GLU n 
1 239 ASN n 
1 240 SER n 
1 241 LEU n 
1 242 SER n 
1 243 GLY n 
1 244 VAL n 
1 245 GLU n 
1 246 GLY n 
1 247 GLU n 
1 248 GLY n 
1 249 LEU n 
1 250 HIS n 
1 251 LYS n 
1 252 LEU n 
1 253 GLY n 
1 254 TYR n 
1 255 ILE n 
1 256 LEU n 
1 257 ARG n 
1 258 ASP n 
1 259 VAL n 
1 260 SER n 
1 261 LYS n 
1 262 LYS n 
1 263 GLU n 
1 264 GLY n 
1 265 GLY n 
1 266 ALA n 
1 267 MET n 
1 268 TYR n 
1 269 ALA n 
1 270 ASP n 
1 271 ASP n 
1 272 THR n 
1 273 ALA n 
1 274 GLY n 
1 275 TRP n 
1 276 ASP n 
1 277 THR n 
1 278 ARG n 
1 279 ILE n 
1 280 THR n 
1 281 LEU n 
1 282 GLU n 
1 283 ASP n 
1 284 LEU n 
1 285 LYS n 
1 286 ASN n 
1 287 GLU n 
1 288 GLU n 
1 289 MET n 
1 290 VAL n 
1 291 THR n 
1 292 ASN n 
1 293 HIS n 
1 294 MET n 
1 295 GLU n 
1 296 GLY n 
1 297 GLU n 
1 298 HIS n 
1 299 LYS n 
1 300 LYS n 
1 301 LEU n 
1 302 ALA n 
1 303 GLU n 
1 304 ALA n 
1 305 ILE n 
1 306 PHE n 
1 307 LYS n 
1 308 LEU n 
1 309 THR n 
1 310 TYR n 
1 311 GLN n 
1 312 ASN n 
1 313 LYS n 
1 314 VAL n 
1 315 VAL n 
1 316 ARG n 
1 317 VAL n 
1 318 GLN n 
1 319 ARG n 
1 320 PRO n 
1 321 THR n 
1 322 PRO n 
1 323 ARG n 
1 324 GLY n 
1 325 THR n 
1 326 VAL n 
1 327 MET n 
1 328 ASP n 
1 329 ILE n 
1 330 ILE n 
1 331 SER n 
1 332 ARG n 
1 333 ARG n 
1 334 ASP n 
1 335 GLN n 
1 336 ARG n 
1 337 GLY n 
1 338 SER n 
1 339 GLY n 
1 340 GLN n 
1 341 VAL n 
1 342 VAL n 
1 343 THR n 
1 344 TYR n 
1 345 GLY n 
1 346 LEU n 
1 347 ASN n 
1 348 THR n 
1 349 PHE n 
1 350 THR n 
1 351 ASN n 
1 352 MET n 
1 353 GLU n 
1 354 ALA n 
1 355 GLN n 
1 356 LEU n 
1 357 ILE n 
1 358 ARG n 
1 359 GLN n 
1 360 MET n 
1 361 GLU n 
1 362 GLY n 
1 363 GLU n 
1 364 GLY n 
1 365 VAL n 
1 366 PHE n 
1 367 LYS n 
1 368 SER n 
1 369 ILE n 
1 370 GLN n 
1 371 HIS n 
1 372 LEU n 
1 373 THR n 
1 374 VAL n 
1 375 THR n 
1 376 GLU n 
1 377 GLU n 
1 378 ILE n 
1 379 ALA n 
1 380 VAL n 
1 381 LYS n 
1 382 ASN n 
1 383 TRP n 
1 384 LEU n 
1 385 VAL n 
1 386 ARG n 
1 387 VAL n 
1 388 GLY n 
1 389 ARG n 
1 390 GLU n 
1 391 ARG n 
1 392 LEU n 
1 393 SER n 
1 394 ARG n 
1 395 MET n 
1 396 ALA n 
1 397 ILE n 
1 398 SER n 
1 399 GLY n 
1 400 ASP n 
1 401 ASP n 
1 402 CYS n 
1 403 VAL n 
1 404 VAL n 
1 405 LYS n 
1 406 PRO n 
1 407 LEU n 
1 408 ASP n 
1 409 ASP n 
1 410 ARG n 
1 411 PHE n 
1 412 ALA n 
1 413 SER n 
1 414 ALA n 
1 415 LEU n 
1 416 THR n 
1 417 ALA n 
1 418 LEU n 
1 419 ASN n 
1 420 ASP n 
1 421 MET n 
1 422 GLY n 
1 423 LYS n 
1 424 VAL n 
1 425 ARG n 
1 426 LYS n 
1 427 ASP n 
1 428 ILE n 
1 429 GLN n 
1 430 GLN n 
1 431 TRP n 
1 432 GLU n 
1 433 PRO n 
1 434 SER n 
1 435 ARG n 
1 436 GLY n 
1 437 TRP n 
1 438 ASN n 
1 439 ASP n 
1 440 TRP n 
1 441 THR n 
1 442 GLN n 
1 443 VAL n 
1 444 PRO n 
1 445 PHE n 
1 446 CYS n 
1 447 SER n 
1 448 HIS n 
1 449 HIS n 
1 450 PHE n 
1 451 HIS n 
1 452 GLU n 
1 453 LEU n 
1 454 ILE n 
1 455 MET n 
1 456 LYS n 
1 457 ASP n 
1 458 GLY n 
1 459 ARG n 
1 460 VAL n 
1 461 LEU n 
1 462 VAL n 
1 463 VAL n 
1 464 PRO n 
1 465 CYS n 
1 466 ARG n 
1 467 ASN n 
1 468 GLN n 
1 469 ASP n 
1 470 GLU n 
1 471 LEU n 
1 472 ILE n 
1 473 GLY n 
1 474 ARG n 
1 475 ALA n 
1 476 ARG n 
1 477 ILE n 
1 478 SER n 
1 479 GLN n 
1 480 GLY n 
1 481 ALA n 
1 482 GLY n 
1 483 TRP n 
1 484 SER n 
1 485 LEU n 
1 486 ARG n 
1 487 GLU n 
1 488 THR n 
1 489 ALA n 
1 490 CYS n 
1 491 LEU n 
1 492 GLY n 
1 493 LYS n 
1 494 SER n 
1 495 TYR n 
1 496 ALA n 
1 497 GLN n 
1 498 MET n 
1 499 TRP n 
1 500 SER n 
1 501 LEU n 
1 502 MET n 
1 503 TYR n 
1 504 PHE n 
1 505 HIS n 
1 506 ARG n 
1 507 ARG n 
1 508 ASP n 
1 509 LEU n 
1 510 ARG n 
1 511 LEU n 
1 512 ALA n 
1 513 ALA n 
1 514 ASN n 
1 515 ALA n 
1 516 ILE n 
1 517 CYS n 
1 518 SER n 
1 519 ALA n 
1 520 VAL n 
1 521 PRO n 
1 522 SER n 
1 523 HIS n 
1 524 TRP n 
1 525 VAL n 
1 526 PRO n 
1 527 THR n 
1 528 SER n 
1 529 ARG n 
1 530 THR n 
1 531 THR n 
1 532 TRP n 
1 533 SER n 
1 534 ILE n 
1 535 HIS n 
1 536 ALA n 
1 537 THR n 
1 538 HIS n 
1 539 GLU n 
1 540 TRP n 
1 541 MET n 
1 542 THR n 
1 543 THR n 
1 544 GLU n 
1 545 ASP n 
1 546 MET n 
1 547 LEU n 
1 548 THR n 
1 549 VAL n 
1 550 TRP n 
1 551 ASN n 
1 552 ARG n 
1 553 VAL n 
1 554 TRP n 
1 555 ILE n 
1 556 GLN n 
1 557 GLU n 
1 558 ASN n 
1 559 PRO n 
1 560 TRP n 
1 561 MET n 
1 562 GLU n 
1 563 ASP n 
1 564 LYS n 
1 565 THR n 
1 566 PRO n 
1 567 VAL n 
1 568 GLU n 
1 569 SER n 
1 570 TRP n 
1 571 GLU n 
1 572 GLU n 
1 573 ILE n 
1 574 PRO n 
1 575 TYR n 
1 576 LEU n 
1 577 GLY n 
1 578 LYS n 
1 579 ARG n 
1 580 GLU n 
1 581 ASP n 
1 582 GLN n 
1 583 TRP n 
1 584 CYS n 
1 585 GLY n 
1 586 SER n 
1 587 LEU n 
1 588 ILE n 
1 589 GLY n 
1 590 LEU n 
1 591 THR n 
1 592 SER n 
1 593 ARG n 
1 594 ALA n 
1 595 THR n 
1 596 TRP n 
1 597 ALA n 
1 598 LYS n 
1 599 ASN n 
1 600 ILE n 
1 601 GLN n 
1 602 THR n 
1 603 ALA n 
1 604 ILE n 
1 605 ASN n 
1 606 GLN n 
1 607 VAL n 
1 608 ARG n 
1 609 SER n 
1 610 LEU n 
1 611 ILE n 
1 612 GLY n 
1 613 ASN n 
1 614 GLU n 
1 615 GLU n 
1 616 TYR n 
1 617 THR n 
1 618 ASP n 
1 619 TYR n 
1 620 MET n 
1 621 PRO n 
1 622 SER n 
1 623 MET n 
1 624 LYS n 
1 625 ARG n 
1 626 PHE n 
1 627 ARG n 
1 628 ARG n 
1 629 GLU n 
1 630 GLU n 
1 631 GLU n 
1 632 GLU n 
1 633 ALA n 
1 634 GLY n 
1 635 VAL n 
1 636 LEU n 
1 637 TRP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   637 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'dengue virus type 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     11060 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                                           ? 'C3 H7 N O2'      89.093  
ARG 'L-peptide linking' y ARGININE                                                          ? 'C6 H15 N4 O2 1'  175.209 
ASN 'L-peptide linking' y ASPARAGINE                                                        ? 'C4 H8 N2 O3'     132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                                   ? 'C4 H7 N O4'      133.103 
CYS 'L-peptide linking' y CYSTEINE                                                          ? 'C3 H7 N O2 S'    121.158 
DMS non-polymer         . 'DIMETHYL SULFOXIDE'                                              ? 'C2 H6 O S'       78.133  
GLN 'L-peptide linking' y GLUTAMINE                                                         ? 'C5 H10 N2 O3'    146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                                   ? 'C5 H9 N O4'      147.129 
GLY 'peptide linking'   y GLYCINE                                                           ? 'C2 H5 N O2'      75.067  
HIS 'L-peptide linking' y HISTIDINE                                                         ? 'C6 H10 N3 O2 1'  156.162 
HOH non-polymer         . WATER                                                             ? 'H2 O'            18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                                        ? 'C6 H13 N O2'     131.173 
K07 non-polymer         . '5-chloro-N-methyl-N-{[(3R)-oxolan-3-yl]methyl}pyrimidin-4-amine' ? 'C10 H14 Cl N3 O' 227.691 
LEU 'L-peptide linking' y LEUCINE                                                           ? 'C6 H13 N O2'     131.173 
LYS 'L-peptide linking' y LYSINE                                                            ? 'C6 H15 N2 O2 1'  147.195 
MES non-polymer         . '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                            ? 'C6 H13 N O4 S'   195.237 
MET 'L-peptide linking' y METHIONINE                                                        ? 'C5 H11 N O2 S'   149.211 
PEG non-polymer         . 'DI(HYDROXYETHYL)ETHER'                                           ? 'C4 H10 O3'       106.120 
PHE 'L-peptide linking' y PHENYLALANINE                                                     ? 'C9 H11 N O2'     165.189 
PO4 non-polymer         . 'PHOSPHATE ION'                                                   ? 'O4 P -3'         94.971  
PRO 'L-peptide linking' y PROLINE                                                           ? 'C5 H9 N O2'      115.130 
SER 'L-peptide linking' y SERINE                                                            ? 'C3 H7 N O3'      105.093 
THR 'L-peptide linking' y THREONINE                                                         ? 'C4 H9 N O3'      119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                                        ? 'C11 H12 N2 O2'   204.225 
TYR 'L-peptide linking' y TYROSINE                                                          ? 'C9 H11 N O3'     181.189 
VAL 'L-peptide linking' y VALINE                                                            ? 'C5 H11 N O2'     117.146 
ZN  non-polymer         . 'ZINC ION'                                                        ? 'Zn 2'            65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   264 ?   ?   ?   A . n 
A 1 2   PRO 2   265 ?   ?   ?   A . n 
A 1 3   GLY 3   266 ?   ?   ?   A . n 
A 1 4   ILE 4   267 ?   ?   ?   A . n 
A 1 5   GLU 5   268 ?   ?   ?   A . n 
A 1 6   SER 6   269 ?   ?   ?   A . n 
A 1 7   GLU 7   270 ?   ?   ?   A . n 
A 1 8   THR 8   271 ?   ?   ?   A . n 
A 1 9   PRO 9   272 ?   ?   ?   A . n 
A 1 10  ASN 10  273 273 ASN ASN A . n 
A 1 11  LEU 11  274 274 LEU LEU A . n 
A 1 12  ASP 12  275 275 ASP ASP A . n 
A 1 13  ILE 13  276 276 ILE ILE A . n 
A 1 14  ILE 14  277 277 ILE ILE A . n 
A 1 15  GLY 15  278 278 GLY GLY A . n 
A 1 16  LYS 16  279 279 LYS LYS A . n 
A 1 17  ARG 17  280 280 ARG ARG A . n 
A 1 18  ILE 18  281 281 ILE ILE A . n 
A 1 19  GLU 19  282 282 GLU GLU A . n 
A 1 20  LYS 20  283 283 LYS LYS A . n 
A 1 21  ILE 21  284 284 ILE ILE A . n 
A 1 22  LYS 22  285 285 LYS LYS A . n 
A 1 23  GLN 23  286 286 GLN GLN A . n 
A 1 24  GLU 24  287 287 GLU GLU A . n 
A 1 25  HIS 25  288 288 HIS HIS A . n 
A 1 26  GLU 26  289 289 GLU GLU A . n 
A 1 27  THR 27  290 290 THR THR A . n 
A 1 28  SER 28  291 291 SER SER A . n 
A 1 29  TRP 29  292 292 TRP TRP A . n 
A 1 30  HIS 30  293 293 HIS HIS A . n 
A 1 31  TYR 31  294 294 TYR TYR A . n 
A 1 32  ASP 32  295 295 ASP ASP A . n 
A 1 33  GLN 33  296 296 GLN GLN A . n 
A 1 34  ASP 34  297 297 ASP ASP A . n 
A 1 35  HIS 35  298 298 HIS HIS A . n 
A 1 36  PRO 36  299 299 PRO PRO A . n 
A 1 37  TYR 37  300 300 TYR TYR A . n 
A 1 38  LYS 38  301 301 LYS LYS A . n 
A 1 39  THR 39  302 302 THR THR A . n 
A 1 40  TRP 40  303 303 TRP TRP A . n 
A 1 41  ALA 41  304 304 ALA ALA A . n 
A 1 42  TYR 42  305 305 TYR TYR A . n 
A 1 43  HIS 43  306 306 HIS HIS A . n 
A 1 44  GLY 44  307 307 GLY GLY A . n 
A 1 45  SER 45  308 308 SER SER A . n 
A 1 46  TYR 46  309 309 TYR TYR A . n 
A 1 47  GLU 47  310 310 GLU GLU A . n 
A 1 48  THR 48  311 311 THR THR A . n 
A 1 49  LYS 49  312 312 LYS LYS A . n 
A 1 50  GLN 50  313 ?   ?   ?   A . n 
A 1 51  THR 51  314 ?   ?   ?   A . n 
A 1 52  GLY 52  315 ?   ?   ?   A . n 
A 1 53  SER 53  316 ?   ?   ?   A . n 
A 1 54  ALA 54  317 ?   ?   ?   A . n 
A 1 55  SER 55  318 318 SER SER A . n 
A 1 56  SER 56  319 319 SER SER A . n 
A 1 57  MET 57  320 320 MET MET A . n 
A 1 58  VAL 58  321 321 VAL VAL A . n 
A 1 59  ASN 59  322 322 ASN ASN A . n 
A 1 60  GLY 60  323 323 GLY GLY A . n 
A 1 61  VAL 61  324 324 VAL VAL A . n 
A 1 62  VAL 62  325 325 VAL VAL A . n 
A 1 63  ARG 63  326 326 ARG ARG A . n 
A 1 64  LEU 64  327 327 LEU LEU A . n 
A 1 65  LEU 65  328 328 LEU LEU A . n 
A 1 66  THR 66  329 329 THR THR A . n 
A 1 67  LYS 67  330 330 LYS LYS A . n 
A 1 68  PRO 68  331 331 PRO PRO A . n 
A 1 69  TRP 69  332 332 TRP TRP A . n 
A 1 70  ASP 70  333 333 ASP ASP A . n 
A 1 71  ILE 71  334 334 ILE ILE A . n 
A 1 72  ILE 72  335 335 ILE ILE A . n 
A 1 73  PRO 73  336 336 PRO PRO A . n 
A 1 74  MET 74  337 337 MET MET A . n 
A 1 75  VAL 75  338 338 VAL VAL A . n 
A 1 76  THR 76  339 339 THR THR A . n 
A 1 77  GLN 77  340 340 GLN GLN A . n 
A 1 78  MET 78  341 341 MET MET A . n 
A 1 79  ALA 79  342 342 ALA ALA A . n 
A 1 80  MET 80  343 343 MET MET A . n 
A 1 81  THR 81  344 344 THR GLY A . n 
A 1 82  ASP 82  345 ?   ?   ?   A . n 
A 1 83  THR 83  346 ?   ?   ?   A . n 
A 1 84  THR 84  347 ?   ?   ?   A . n 
A 1 85  PRO 85  348 ?   ?   ?   A . n 
A 1 86  PHE 86  349 ?   ?   ?   A . n 
A 1 87  GLY 87  350 ?   ?   ?   A . n 
A 1 88  GLN 88  351 ?   ?   ?   A . n 
A 1 89  GLN 89  352 ?   ?   ?   A . n 
A 1 90  ARG 90  353 ?   ?   ?   A . n 
A 1 91  VAL 91  354 ?   ?   ?   A . n 
A 1 92  PHE 92  355 ?   ?   ?   A . n 
A 1 93  LYS 93  356 356 LYS LYS A . n 
A 1 94  GLU 94  357 357 GLU GLU A . n 
A 1 95  LYS 95  358 358 LYS LYS A . n 
A 1 96  VAL 96  359 359 VAL VAL A . n 
A 1 97  ASP 97  360 360 ASP ASP A . n 
A 1 98  THR 98  361 361 THR THR A . n 
A 1 99  ARG 99  362 362 ARG ARG A . n 
A 1 100 THR 100 363 363 THR THR A . n 
A 1 101 GLN 101 364 364 GLN GLN A . n 
A 1 102 GLU 102 365 365 GLU GLU A . n 
A 1 103 PRO 103 366 366 PRO PRO A . n 
A 1 104 LYS 104 367 367 LYS LYS A . n 
A 1 105 GLU 105 368 368 GLU GLU A . n 
A 1 106 GLY 106 369 369 GLY GLY A . n 
A 1 107 THR 107 370 370 THR THR A . n 
A 1 108 LYS 108 371 371 LYS LYS A . n 
A 1 109 LYS 109 372 372 LYS LYS A . n 
A 1 110 LEU 110 373 373 LEU LEU A . n 
A 1 111 MET 111 374 374 MET MET A . n 
A 1 112 LYS 112 375 375 LYS LYS A . n 
A 1 113 ILE 113 376 376 ILE ILE A . n 
A 1 114 THR 114 377 377 THR THR A . n 
A 1 115 ALA 115 378 378 ALA ALA A . n 
A 1 116 GLU 116 379 379 GLU GLU A . n 
A 1 117 TRP 117 380 380 TRP TRP A . n 
A 1 118 LEU 118 381 381 LEU LEU A . n 
A 1 119 TRP 119 382 382 TRP TRP A . n 
A 1 120 LYS 120 383 383 LYS LYS A . n 
A 1 121 GLU 121 384 384 GLU GLU A . n 
A 1 122 LEU 122 385 385 LEU LEU A . n 
A 1 123 GLY 123 386 386 GLY GLY A . n 
A 1 124 LYS 124 387 387 LYS LYS A . n 
A 1 125 LYS 125 388 388 LYS LYS A . n 
A 1 126 LYS 126 389 389 LYS LYS A . n 
A 1 127 THR 127 390 390 THR THR A . n 
A 1 128 PRO 128 391 391 PRO PRO A . n 
A 1 129 ARG 129 392 392 ARG ARG A . n 
A 1 130 MET 130 393 393 MET MET A . n 
A 1 131 CYS 131 394 394 CYS CYS A . n 
A 1 132 THR 132 395 395 THR THR A . n 
A 1 133 ARG 133 396 396 ARG ARG A . n 
A 1 134 GLU 134 397 397 GLU GLU A . n 
A 1 135 GLU 135 398 398 GLU GLU A . n 
A 1 136 PHE 136 399 399 PHE PHE A . n 
A 1 137 THR 137 400 400 THR THR A . n 
A 1 138 ARG 138 401 401 ARG ARG A . n 
A 1 139 LYS 139 402 402 LYS LYS A . n 
A 1 140 VAL 140 403 403 VAL VAL A . n 
A 1 141 ARG 141 404 404 ARG ARG A . n 
A 1 142 SER 142 405 405 SER SER A . n 
A 1 143 ASN 143 406 406 ASN ASN A . n 
A 1 144 ALA 144 407 407 ALA ALA A . n 
A 1 145 ALA 145 408 408 ALA ALA A . n 
A 1 146 LEU 146 409 409 LEU LEU A . n 
A 1 147 GLY 147 410 410 GLY GLY A . n 
A 1 148 ALA 148 411 ?   ?   ?   A . n 
A 1 149 ILE 149 412 ?   ?   ?   A . n 
A 1 150 PHE 150 413 ?   ?   ?   A . n 
A 1 151 THR 151 414 ?   ?   ?   A . n 
A 1 152 ASP 152 415 ?   ?   ?   A . n 
A 1 153 GLU 153 416 ?   ?   ?   A . n 
A 1 154 ASN 154 417 ?   ?   ?   A . n 
A 1 155 LYS 155 418 418 LYS LYS A . n 
A 1 156 TRP 156 419 419 TRP TRP A . n 
A 1 157 LYS 157 420 420 LYS LYS A . n 
A 1 158 SER 158 421 421 SER SER A . n 
A 1 159 ALA 159 422 422 ALA ALA A . n 
A 1 160 ARG 160 423 423 ARG ARG A . n 
A 1 161 GLU 161 424 424 GLU GLU A . n 
A 1 162 ALA 162 425 425 ALA ALA A . n 
A 1 163 VAL 163 426 426 VAL VAL A . n 
A 1 164 GLU 164 427 427 GLU GLU A . n 
A 1 165 ASP 165 428 428 ASP ASP A . n 
A 1 166 SER 166 429 429 SER SER A . n 
A 1 167 GLY 167 430 430 GLY GLY A . n 
A 1 168 PHE 168 431 431 PHE PHE A . n 
A 1 169 TRP 169 432 432 TRP TRP A . n 
A 1 170 GLU 170 433 433 GLU GLU A . n 
A 1 171 LEU 171 434 434 LEU LEU A . n 
A 1 172 VAL 172 435 435 VAL VAL A . n 
A 1 173 ASP 173 436 436 ASP ASP A . n 
A 1 174 LYS 174 437 437 LYS LYS A . n 
A 1 175 GLU 175 438 438 GLU GLU A . n 
A 1 176 ARG 176 439 439 ARG ARG A . n 
A 1 177 ASN 177 440 440 ASN ASN A . n 
A 1 178 LEU 178 441 441 LEU LEU A . n 
A 1 179 HIS 179 442 442 HIS HIS A . n 
A 1 180 LEU 180 443 443 LEU LEU A . n 
A 1 181 GLU 181 444 444 GLU GLU A . n 
A 1 182 GLY 182 445 445 GLY GLY A . n 
A 1 183 LYS 183 446 446 LYS LYS A . n 
A 1 184 CYS 184 447 447 CYS CYS A . n 
A 1 185 GLU 185 448 448 GLU GLU A . n 
A 1 186 THR 186 449 449 THR THR A . n 
A 1 187 CYS 187 450 450 CYS CYS A . n 
A 1 188 VAL 188 451 451 VAL VAL A . n 
A 1 189 TYR 189 452 452 TYR TYR A . n 
A 1 190 ASN 190 453 453 ASN ASN A . n 
A 1 191 MET 191 454 454 MET MET A . n 
A 1 192 MET 192 455 455 MET MET A . n 
A 1 193 GLY 193 456 ?   ?   ?   A . n 
A 1 194 LYS 194 457 ?   ?   ?   A . n 
A 1 195 ARG 195 458 ?   ?   ?   A . n 
A 1 196 GLU 196 459 ?   ?   ?   A . n 
A 1 197 LYS 197 460 ?   ?   ?   A . n 
A 1 198 LYS 198 461 ?   ?   ?   A . n 
A 1 199 LEU 199 462 ?   ?   ?   A . n 
A 1 200 GLY 200 463 ?   ?   ?   A . n 
A 1 201 GLU 201 464 ?   ?   ?   A . n 
A 1 202 PHE 202 465 ?   ?   ?   A . n 
A 1 203 GLY 203 466 ?   ?   ?   A . n 
A 1 204 LYS 204 467 ?   ?   ?   A . n 
A 1 205 ALA 205 468 ?   ?   ?   A . n 
A 1 206 LYS 206 469 ?   ?   ?   A . n 
A 1 207 GLY 207 470 ?   ?   ?   A . n 
A 1 208 SER 208 471 ?   ?   ?   A . n 
A 1 209 ARG 209 472 ?   ?   ?   A . n 
A 1 210 ALA 210 473 473 ALA ALA A . n 
A 1 211 ILE 211 474 474 ILE ILE A . n 
A 1 212 TRP 212 475 475 TRP TRP A . n 
A 1 213 TYR 213 476 476 TYR TYR A . n 
A 1 214 MET 214 477 477 MET MET A . n 
A 1 215 TRP 215 478 478 TRP TRP A . n 
A 1 216 LEU 216 479 479 LEU LEU A . n 
A 1 217 GLY 217 480 480 GLY GLY A . n 
A 1 218 ALA 218 481 481 ALA ALA A . n 
A 1 219 ARG 219 482 482 ARG ARG A . n 
A 1 220 PHE 220 483 483 PHE PHE A . n 
A 1 221 LEU 221 484 484 LEU LEU A . n 
A 1 222 GLU 222 485 485 GLU GLU A . n 
A 1 223 PHE 223 486 486 PHE PHE A . n 
A 1 224 GLU 224 487 487 GLU GLU A . n 
A 1 225 ALA 225 488 488 ALA ALA A . n 
A 1 226 LEU 226 489 489 LEU LEU A . n 
A 1 227 GLY 227 490 490 GLY GLY A . n 
A 1 228 PHE 228 491 491 PHE PHE A . n 
A 1 229 LEU 229 492 492 LEU LEU A . n 
A 1 230 ASN 230 493 493 ASN ASN A . n 
A 1 231 GLU 231 494 494 GLU GLU A . n 
A 1 232 ASP 232 495 495 ASP ASP A . n 
A 1 233 HIS 233 496 496 HIS HIS A . n 
A 1 234 TRP 234 497 497 TRP TRP A . n 
A 1 235 PHE 235 498 498 PHE PHE A . n 
A 1 236 SER 236 499 499 SER SER A . n 
A 1 237 ARG 237 500 500 ARG ARG A . n 
A 1 238 GLU 238 501 501 GLU GLU A . n 
A 1 239 ASN 239 502 502 ASN ASN A . n 
A 1 240 SER 240 503 503 SER SER A . n 
A 1 241 LEU 241 504 504 LEU LEU A . n 
A 1 242 SER 242 505 505 SER SER A . n 
A 1 243 GLY 243 506 506 GLY GLY A . n 
A 1 244 VAL 244 507 507 VAL VAL A . n 
A 1 245 GLU 245 508 508 GLU GLU A . n 
A 1 246 GLY 246 509 509 GLY GLY A . n 
A 1 247 GLU 247 510 510 GLU GLU A . n 
A 1 248 GLY 248 511 511 GLY GLY A . n 
A 1 249 LEU 249 512 512 LEU LEU A . n 
A 1 250 HIS 250 513 513 HIS HIS A . n 
A 1 251 LYS 251 514 514 LYS LYS A . n 
A 1 252 LEU 252 515 515 LEU LEU A . n 
A 1 253 GLY 253 516 516 GLY GLY A . n 
A 1 254 TYR 254 517 517 TYR TYR A . n 
A 1 255 ILE 255 518 518 ILE ILE A . n 
A 1 256 LEU 256 519 519 LEU LEU A . n 
A 1 257 ARG 257 520 520 ARG ARG A . n 
A 1 258 ASP 258 521 521 ASP ASP A . n 
A 1 259 VAL 259 522 522 VAL VAL A . n 
A 1 260 SER 260 523 523 SER SER A . n 
A 1 261 LYS 261 524 524 LYS LYS A . n 
A 1 262 LYS 262 525 525 LYS LYS A . n 
A 1 263 GLU 263 526 526 GLU GLU A . n 
A 1 264 GLY 264 527 527 GLY GLY A . n 
A 1 265 GLY 265 528 528 GLY GLY A . n 
A 1 266 ALA 266 529 529 ALA ALA A . n 
A 1 267 MET 267 530 530 MET MET A . n 
A 1 268 TYR 268 531 531 TYR TYR A . n 
A 1 269 ALA 269 532 532 ALA ALA A . n 
A 1 270 ASP 270 533 533 ASP ASP A . n 
A 1 271 ASP 271 534 534 ASP ASP A . n 
A 1 272 THR 272 535 535 THR THR A . n 
A 1 273 ALA 273 536 536 ALA ALA A . n 
A 1 274 GLY 274 537 537 GLY GLY A . n 
A 1 275 TRP 275 538 538 TRP TRP A . n 
A 1 276 ASP 276 539 539 ASP ASP A . n 
A 1 277 THR 277 540 540 THR THR A . n 
A 1 278 ARG 278 541 541 ARG ARG A . n 
A 1 279 ILE 279 542 542 ILE ILE A . n 
A 1 280 THR 280 543 543 THR THR A . n 
A 1 281 LEU 281 544 544 LEU LEU A . n 
A 1 282 GLU 282 545 545 GLU GLU A . n 
A 1 283 ASP 283 546 546 ASP ASP A . n 
A 1 284 LEU 284 547 547 LEU LEU A . n 
A 1 285 LYS 285 548 548 LYS LYS A . n 
A 1 286 ASN 286 549 549 ASN ASN A . n 
A 1 287 GLU 287 550 550 GLU GLU A . n 
A 1 288 GLU 288 551 551 GLU GLU A . n 
A 1 289 MET 289 552 552 MET MET A . n 
A 1 290 VAL 290 553 553 VAL VAL A . n 
A 1 291 THR 291 554 554 THR THR A . n 
A 1 292 ASN 292 555 555 ASN ASN A . n 
A 1 293 HIS 293 556 556 HIS HIS A . n 
A 1 294 MET 294 557 557 MET MET A . n 
A 1 295 GLU 295 558 558 GLU GLU A . n 
A 1 296 GLY 296 559 559 GLY GLY A . n 
A 1 297 GLU 297 560 560 GLU GLU A . n 
A 1 298 HIS 298 561 561 HIS HIS A . n 
A 1 299 LYS 299 562 562 LYS LYS A . n 
A 1 300 LYS 300 563 563 LYS LYS A . n 
A 1 301 LEU 301 564 564 LEU LEU A . n 
A 1 302 ALA 302 565 565 ALA ALA A . n 
A 1 303 GLU 303 566 566 GLU GLU A . n 
A 1 304 ALA 304 567 567 ALA ALA A . n 
A 1 305 ILE 305 568 568 ILE ILE A . n 
A 1 306 PHE 306 569 569 PHE PHE A . n 
A 1 307 LYS 307 570 570 LYS LYS A . n 
A 1 308 LEU 308 571 571 LEU LEU A . n 
A 1 309 THR 309 572 572 THR THR A . n 
A 1 310 TYR 310 573 573 TYR TYR A . n 
A 1 311 GLN 311 574 574 GLN GLN A . n 
A 1 312 ASN 312 575 575 ASN ASN A . n 
A 1 313 LYS 313 576 576 LYS LYS A . n 
A 1 314 VAL 314 577 577 VAL VAL A . n 
A 1 315 VAL 315 578 578 VAL VAL A . n 
A 1 316 ARG 316 579 579 ARG ARG A . n 
A 1 317 VAL 317 580 580 VAL VAL A . n 
A 1 318 GLN 318 581 581 GLN GLN A . n 
A 1 319 ARG 319 582 582 ARG ARG A . n 
A 1 320 PRO 320 583 583 PRO PRO A . n 
A 1 321 THR 321 584 584 THR THR A . n 
A 1 322 PRO 322 585 ?   ?   ?   A . n 
A 1 323 ARG 323 586 ?   ?   ?   A . n 
A 1 324 GLY 324 587 ?   ?   ?   A . n 
A 1 325 THR 325 588 588 THR THR A . n 
A 1 326 VAL 326 589 589 VAL VAL A . n 
A 1 327 MET 327 590 590 MET MET A . n 
A 1 328 ASP 328 591 591 ASP ASP A . n 
A 1 329 ILE 329 592 592 ILE ILE A . n 
A 1 330 ILE 330 593 593 ILE ILE A . n 
A 1 331 SER 331 594 594 SER SER A . n 
A 1 332 ARG 332 595 595 ARG ARG A . n 
A 1 333 ARG 333 596 596 ARG ARG A . n 
A 1 334 ASP 334 597 597 ASP ASP A . n 
A 1 335 GLN 335 598 598 GLN GLN A . n 
A 1 336 ARG 336 599 599 ARG ARG A . n 
A 1 337 GLY 337 600 600 GLY GLY A . n 
A 1 338 SER 338 601 601 SER SER A . n 
A 1 339 GLY 339 602 602 GLY GLY A . n 
A 1 340 GLN 340 603 603 GLN GLN A . n 
A 1 341 VAL 341 604 604 VAL VAL A . n 
A 1 342 VAL 342 605 605 VAL VAL A . n 
A 1 343 THR 343 606 606 THR THR A . n 
A 1 344 TYR 344 607 607 TYR TYR A . n 
A 1 345 GLY 345 608 608 GLY GLY A . n 
A 1 346 LEU 346 609 609 LEU LEU A . n 
A 1 347 ASN 347 610 610 ASN ASN A . n 
A 1 348 THR 348 611 611 THR THR A . n 
A 1 349 PHE 349 612 612 PHE PHE A . n 
A 1 350 THR 350 613 613 THR THR A . n 
A 1 351 ASN 351 614 614 ASN ASN A . n 
A 1 352 MET 352 615 615 MET MET A . n 
A 1 353 GLU 353 616 616 GLU GLU A . n 
A 1 354 ALA 354 617 617 ALA ALA A . n 
A 1 355 GLN 355 618 618 GLN GLN A . n 
A 1 356 LEU 356 619 619 LEU LEU A . n 
A 1 357 ILE 357 620 620 ILE ILE A . n 
A 1 358 ARG 358 621 621 ARG ARG A . n 
A 1 359 GLN 359 622 622 GLN GLN A . n 
A 1 360 MET 360 623 623 MET MET A . n 
A 1 361 GLU 361 624 624 GLU GLU A . n 
A 1 362 GLY 362 625 625 GLY GLY A . n 
A 1 363 GLU 363 626 626 GLU GLU A . n 
A 1 364 GLY 364 627 627 GLY GLY A . n 
A 1 365 VAL 365 628 628 VAL VAL A . n 
A 1 366 PHE 366 629 629 PHE PHE A . n 
A 1 367 LYS 367 630 630 LYS LYS A . n 
A 1 368 SER 368 631 631 SER SER A . n 
A 1 369 ILE 369 632 632 ILE ILE A . n 
A 1 370 GLN 370 633 633 GLN GLN A . n 
A 1 371 HIS 371 634 634 HIS HIS A . n 
A 1 372 LEU 372 635 635 LEU LEU A . n 
A 1 373 THR 373 636 636 THR THR A . n 
A 1 374 VAL 374 637 637 VAL VAL A . n 
A 1 375 THR 375 638 638 THR THR A . n 
A 1 376 GLU 376 639 639 GLU GLU A . n 
A 1 377 GLU 377 640 640 GLU GLU A . n 
A 1 378 ILE 378 641 641 ILE ILE A . n 
A 1 379 ALA 379 642 642 ALA ALA A . n 
A 1 380 VAL 380 643 643 VAL VAL A . n 
A 1 381 LYS 381 644 644 LYS LYS A . n 
A 1 382 ASN 382 645 645 ASN ASN A . n 
A 1 383 TRP 383 646 646 TRP TRP A . n 
A 1 384 LEU 384 647 647 LEU LEU A . n 
A 1 385 VAL 385 648 648 VAL VAL A . n 
A 1 386 ARG 386 649 649 ARG ARG A . n 
A 1 387 VAL 387 650 650 VAL VAL A . n 
A 1 388 GLY 388 651 651 GLY GLY A . n 
A 1 389 ARG 389 652 652 ARG ARG A . n 
A 1 390 GLU 390 653 653 GLU GLU A . n 
A 1 391 ARG 391 654 654 ARG ARG A . n 
A 1 392 LEU 392 655 655 LEU LEU A . n 
A 1 393 SER 393 656 656 SER SER A . n 
A 1 394 ARG 394 657 657 ARG ARG A . n 
A 1 395 MET 395 658 658 MET MET A . n 
A 1 396 ALA 396 659 659 ALA ALA A . n 
A 1 397 ILE 397 660 660 ILE ILE A . n 
A 1 398 SER 398 661 661 SER SER A . n 
A 1 399 GLY 399 662 662 GLY GLY A . n 
A 1 400 ASP 400 663 663 ASP ASP A . n 
A 1 401 ASP 401 664 664 ASP ASP A . n 
A 1 402 CYS 402 665 665 CYS CYS A . n 
A 1 403 VAL 403 666 666 VAL VAL A . n 
A 1 404 VAL 404 667 667 VAL VAL A . n 
A 1 405 LYS 405 668 668 LYS LYS A . n 
A 1 406 PRO 406 669 669 PRO PRO A . n 
A 1 407 LEU 407 670 670 LEU LEU A . n 
A 1 408 ASP 408 671 671 ASP ASP A . n 
A 1 409 ASP 409 672 672 ASP ASP A . n 
A 1 410 ARG 410 673 673 ARG ARG A . n 
A 1 411 PHE 411 674 674 PHE PHE A . n 
A 1 412 ALA 412 675 675 ALA ALA A . n 
A 1 413 SER 413 676 676 SER SER A . n 
A 1 414 ALA 414 677 677 ALA ALA A . n 
A 1 415 LEU 415 678 678 LEU LEU A . n 
A 1 416 THR 416 679 679 THR THR A . n 
A 1 417 ALA 417 680 680 ALA ALA A . n 
A 1 418 LEU 418 681 681 LEU LEU A . n 
A 1 419 ASN 419 682 682 ASN ASN A . n 
A 1 420 ASP 420 683 683 ASP ASP A . n 
A 1 421 MET 421 684 684 MET MET A . n 
A 1 422 GLY 422 685 685 GLY GLY A . n 
A 1 423 LYS 423 686 686 LYS LYS A . n 
A 1 424 VAL 424 687 687 VAL VAL A . n 
A 1 425 ARG 425 688 688 ARG ARG A . n 
A 1 426 LYS 426 689 689 LYS LYS A . n 
A 1 427 ASP 427 690 690 ASP ASP A . n 
A 1 428 ILE 428 691 691 ILE ILE A . n 
A 1 429 GLN 429 692 692 GLN GLN A . n 
A 1 430 GLN 430 693 693 GLN GLN A . n 
A 1 431 TRP 431 694 694 TRP TRP A . n 
A 1 432 GLU 432 695 695 GLU GLU A . n 
A 1 433 PRO 433 696 696 PRO PRO A . n 
A 1 434 SER 434 697 697 SER SER A . n 
A 1 435 ARG 435 698 698 ARG ARG A . n 
A 1 436 GLY 436 699 699 GLY GLY A . n 
A 1 437 TRP 437 700 700 TRP TRP A . n 
A 1 438 ASN 438 701 701 ASN ASN A . n 
A 1 439 ASP 439 702 702 ASP ASP A . n 
A 1 440 TRP 440 703 703 TRP TRP A . n 
A 1 441 THR 441 704 704 THR THR A . n 
A 1 442 GLN 442 705 705 GLN GLN A . n 
A 1 443 VAL 443 706 706 VAL VAL A . n 
A 1 444 PRO 444 707 707 PRO PRO A . n 
A 1 445 PHE 445 708 708 PHE PHE A . n 
A 1 446 CYS 446 709 709 CYS CYS A . n 
A 1 447 SER 447 710 710 SER SER A . n 
A 1 448 HIS 448 711 711 HIS HIS A . n 
A 1 449 HIS 449 712 712 HIS HIS A . n 
A 1 450 PHE 450 713 713 PHE PHE A . n 
A 1 451 HIS 451 714 714 HIS HIS A . n 
A 1 452 GLU 452 715 715 GLU GLU A . n 
A 1 453 LEU 453 716 716 LEU LEU A . n 
A 1 454 ILE 454 717 717 ILE ILE A . n 
A 1 455 MET 455 718 718 MET MET A . n 
A 1 456 LYS 456 719 719 LYS LYS A . n 
A 1 457 ASP 457 720 720 ASP ASP A . n 
A 1 458 GLY 458 721 721 GLY GLY A . n 
A 1 459 ARG 459 722 722 ARG ARG A . n 
A 1 460 VAL 460 723 723 VAL VAL A . n 
A 1 461 LEU 461 724 724 LEU LEU A . n 
A 1 462 VAL 462 725 725 VAL VAL A . n 
A 1 463 VAL 463 726 726 VAL VAL A . n 
A 1 464 PRO 464 727 727 PRO PRO A . n 
A 1 465 CYS 465 728 728 CYS CYS A . n 
A 1 466 ARG 466 729 729 ARG ARG A . n 
A 1 467 ASN 467 730 730 ASN ASN A . n 
A 1 468 GLN 468 731 731 GLN GLN A . n 
A 1 469 ASP 469 732 732 ASP ASP A . n 
A 1 470 GLU 470 733 733 GLU GLU A . n 
A 1 471 LEU 471 734 734 LEU LEU A . n 
A 1 472 ILE 472 735 735 ILE ILE A . n 
A 1 473 GLY 473 736 736 GLY GLY A . n 
A 1 474 ARG 474 737 737 ARG ARG A . n 
A 1 475 ALA 475 738 738 ALA ALA A . n 
A 1 476 ARG 476 739 739 ARG ARG A . n 
A 1 477 ILE 477 740 740 ILE ILE A . n 
A 1 478 SER 478 741 741 SER SER A . n 
A 1 479 GLN 479 742 742 GLN GLN A . n 
A 1 480 GLY 480 743 743 GLY GLY A . n 
A 1 481 ALA 481 744 744 ALA ALA A . n 
A 1 482 GLY 482 745 745 GLY GLY A . n 
A 1 483 TRP 483 746 746 TRP TRP A . n 
A 1 484 SER 484 747 747 SER SER A . n 
A 1 485 LEU 485 748 748 LEU LEU A . n 
A 1 486 ARG 486 749 749 ARG ARG A . n 
A 1 487 GLU 487 750 750 GLU GLU A . n 
A 1 488 THR 488 751 751 THR THR A . n 
A 1 489 ALA 489 752 752 ALA ALA A . n 
A 1 490 CYS 490 753 753 CYS CYS A . n 
A 1 491 LEU 491 754 754 LEU LEU A . n 
A 1 492 GLY 492 755 755 GLY GLY A . n 
A 1 493 LYS 493 756 756 LYS LYS A . n 
A 1 494 SER 494 757 757 SER SER A . n 
A 1 495 TYR 495 758 758 TYR TYR A . n 
A 1 496 ALA 496 759 759 ALA ALA A . n 
A 1 497 GLN 497 760 760 GLN GLN A . n 
A 1 498 MET 498 761 761 MET MET A . n 
A 1 499 TRP 499 762 762 TRP TRP A . n 
A 1 500 SER 500 763 763 SER SER A . n 
A 1 501 LEU 501 764 764 LEU LEU A . n 
A 1 502 MET 502 765 765 MET MET A . n 
A 1 503 TYR 503 766 766 TYR TYR A . n 
A 1 504 PHE 504 767 767 PHE PHE A . n 
A 1 505 HIS 505 768 768 HIS HIS A . n 
A 1 506 ARG 506 769 769 ARG ARG A . n 
A 1 507 ARG 507 770 770 ARG ARG A . n 
A 1 508 ASP 508 771 771 ASP ASP A . n 
A 1 509 LEU 509 772 772 LEU LEU A . n 
A 1 510 ARG 510 773 773 ARG ARG A . n 
A 1 511 LEU 511 774 774 LEU LEU A . n 
A 1 512 ALA 512 775 775 ALA ALA A . n 
A 1 513 ALA 513 776 776 ALA ALA A . n 
A 1 514 ASN 514 777 777 ASN ASN A . n 
A 1 515 ALA 515 778 778 ALA ALA A . n 
A 1 516 ILE 516 779 779 ILE ILE A . n 
A 1 517 CYS 517 780 780 CYS CYS A . n 
A 1 518 SER 518 781 781 SER SER A . n 
A 1 519 ALA 519 782 782 ALA ALA A . n 
A 1 520 VAL 520 783 783 VAL VAL A . n 
A 1 521 PRO 521 784 784 PRO PRO A . n 
A 1 522 SER 522 785 785 SER SER A . n 
A 1 523 HIS 523 786 786 HIS HIS A . n 
A 1 524 TRP 524 787 787 TRP TRP A . n 
A 1 525 VAL 525 788 788 VAL VAL A . n 
A 1 526 PRO 526 789 789 PRO PRO A . n 
A 1 527 THR 527 790 790 THR THR A . n 
A 1 528 SER 528 791 791 SER SER A . n 
A 1 529 ARG 529 792 792 ARG ARG A . n 
A 1 530 THR 530 793 793 THR THR A . n 
A 1 531 THR 531 794 ?   ?   ?   A . n 
A 1 532 TRP 532 795 ?   ?   ?   A . n 
A 1 533 SER 533 796 ?   ?   ?   A . n 
A 1 534 ILE 534 797 ?   ?   ?   A . n 
A 1 535 HIS 535 798 ?   ?   ?   A . n 
A 1 536 ALA 536 799 799 ALA ALA A . n 
A 1 537 THR 537 800 800 THR THR A . n 
A 1 538 HIS 538 801 801 HIS HIS A . n 
A 1 539 GLU 539 802 802 GLU GLU A . n 
A 1 540 TRP 540 803 803 TRP TRP A . n 
A 1 541 MET 541 804 804 MET MET A . n 
A 1 542 THR 542 805 805 THR THR A . n 
A 1 543 THR 543 806 806 THR THR A . n 
A 1 544 GLU 544 807 807 GLU GLU A . n 
A 1 545 ASP 545 808 808 ASP ASP A . n 
A 1 546 MET 546 809 809 MET MET A . n 
A 1 547 LEU 547 810 810 LEU LEU A . n 
A 1 548 THR 548 811 811 THR THR A . n 
A 1 549 VAL 549 812 812 VAL VAL A . n 
A 1 550 TRP 550 813 813 TRP TRP A . n 
A 1 551 ASN 551 814 814 ASN ASN A . n 
A 1 552 ARG 552 815 815 ARG ARG A . n 
A 1 553 VAL 553 816 816 VAL VAL A . n 
A 1 554 TRP 554 817 817 TRP TRP A . n 
A 1 555 ILE 555 818 818 ILE ILE A . n 
A 1 556 GLN 556 819 819 GLN GLN A . n 
A 1 557 GLU 557 820 820 GLU GLU A . n 
A 1 558 ASN 558 821 821 ASN ASN A . n 
A 1 559 PRO 559 822 822 PRO PRO A . n 
A 1 560 TRP 560 823 823 TRP TRP A . n 
A 1 561 MET 561 824 824 MET MET A . n 
A 1 562 GLU 562 825 825 GLU GLU A . n 
A 1 563 ASP 563 826 826 ASP ASP A . n 
A 1 564 LYS 564 827 827 LYS LYS A . n 
A 1 565 THR 565 828 828 THR THR A . n 
A 1 566 PRO 566 829 829 PRO PRO A . n 
A 1 567 VAL 567 830 830 VAL VAL A . n 
A 1 568 GLU 568 831 831 GLU GLU A . n 
A 1 569 SER 569 832 832 SER SER A . n 
A 1 570 TRP 570 833 833 TRP TRP A . n 
A 1 571 GLU 571 834 834 GLU GLU A . n 
A 1 572 GLU 572 835 835 GLU GLU A . n 
A 1 573 ILE 573 836 836 ILE ILE A . n 
A 1 574 PRO 574 837 837 PRO PRO A . n 
A 1 575 TYR 575 838 838 TYR TYR A . n 
A 1 576 LEU 576 839 839 LEU LEU A . n 
A 1 577 GLY 577 840 840 GLY GLY A . n 
A 1 578 LYS 578 841 841 LYS LYS A . n 
A 1 579 ARG 579 842 842 ARG ARG A . n 
A 1 580 GLU 580 843 843 GLU GLU A . n 
A 1 581 ASP 581 844 844 ASP ASP A . n 
A 1 582 GLN 582 845 845 GLN GLN A . n 
A 1 583 TRP 583 846 846 TRP TRP A . n 
A 1 584 CYS 584 847 847 CYS CYS A . n 
A 1 585 GLY 585 848 848 GLY GLY A . n 
A 1 586 SER 586 849 849 SER SER A . n 
A 1 587 LEU 587 850 850 LEU LEU A . n 
A 1 588 ILE 588 851 851 ILE ILE A . n 
A 1 589 GLY 589 852 852 GLY GLY A . n 
A 1 590 LEU 590 853 853 LEU LEU A . n 
A 1 591 THR 591 854 854 THR THR A . n 
A 1 592 SER 592 855 855 SER SER A . n 
A 1 593 ARG 593 856 856 ARG ARG A . n 
A 1 594 ALA 594 857 857 ALA ALA A . n 
A 1 595 THR 595 858 858 THR THR A . n 
A 1 596 TRP 596 859 859 TRP TRP A . n 
A 1 597 ALA 597 860 860 ALA ALA A . n 
A 1 598 LYS 598 861 861 LYS LYS A . n 
A 1 599 ASN 599 862 862 ASN ASN A . n 
A 1 600 ILE 600 863 863 ILE ILE A . n 
A 1 601 GLN 601 864 864 GLN GLN A . n 
A 1 602 THR 602 865 865 THR THR A . n 
A 1 603 ALA 603 866 866 ALA ALA A . n 
A 1 604 ILE 604 867 867 ILE ILE A . n 
A 1 605 ASN 605 868 868 ASN ASN A . n 
A 1 606 GLN 606 869 869 GLN GLN A . n 
A 1 607 VAL 607 870 870 VAL VAL A . n 
A 1 608 ARG 608 871 871 ARG ARG A . n 
A 1 609 SER 609 872 872 SER SER A . n 
A 1 610 LEU 610 873 873 LEU LEU A . n 
A 1 611 ILE 611 874 874 ILE ILE A . n 
A 1 612 GLY 612 875 875 GLY GLY A . n 
A 1 613 ASN 613 876 876 ASN ASN A . n 
A 1 614 GLU 614 877 877 GLU GLU A . n 
A 1 615 GLU 615 878 878 GLU GLU A . n 
A 1 616 TYR 616 879 879 TYR TYR A . n 
A 1 617 THR 617 880 880 THR THR A . n 
A 1 618 ASP 618 881 881 ASP ASP A . n 
A 1 619 TYR 619 882 882 TYR TYR A . n 
A 1 620 MET 620 883 883 MET MET A . n 
A 1 621 PRO 621 884 884 PRO PRO A . n 
A 1 622 SER 622 885 885 SER SER A . n 
A 1 623 MET 623 886 886 MET MET A . n 
A 1 624 LYS 624 887 887 LYS LYS A . n 
A 1 625 ARG 625 888 888 ARG ARG A . n 
A 1 626 PHE 626 889 889 PHE PHE A . n 
A 1 627 ARG 627 890 890 ARG ARG A . n 
A 1 628 ARG 628 891 891 ARG ARG A . n 
A 1 629 GLU 629 892 ?   ?   ?   A . n 
A 1 630 GLU 630 893 ?   ?   ?   A . n 
A 1 631 GLU 631 894 ?   ?   ?   A . n 
A 1 632 GLU 632 895 ?   ?   ?   A . n 
A 1 633 ALA 633 896 ?   ?   ?   A . n 
A 1 634 GLY 634 897 ?   ?   ?   A . n 
A 1 635 VAL 635 898 ?   ?   ?   A . n 
A 1 636 LEU 636 899 ?   ?   ?   A . n 
A 1 637 TRP 637 900 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        K07 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   K07 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 ZN  1   1001 1001 ZN  ZN  A . 
C 2 ZN  1   1002 1002 ZN  ZN  A . 
D 3 MES 1   1003 1004 MES MES A . 
E 4 DMS 1   1004 1530 DMS DMS A . 
F 4 DMS 1   1005 1601 DMS DMS A . 
G 4 DMS 1   1006 1602 DMS DMS A . 
H 5 PO4 1   1007 1604 PO4 PO4 A . 
I 5 PO4 1   1008 1606 PO4 PO4 A . 
J 6 PEG 1   1009 1607 PEG PEG A . 
K 7 K07 1   1010 1801 K07 LIG A . 
L 8 HOH 1   1101 348  HOH HOH A . 
L 8 HOH 2   1102 327  HOH HOH A . 
L 8 HOH 3   1103 175  HOH HOH A . 
L 8 HOH 4   1104 90   HOH HOH A . 
L 8 HOH 5   1105 191  HOH HOH A . 
L 8 HOH 6   1106 3    HOH HOH A . 
L 8 HOH 7   1107 153  HOH HOH A . 
L 8 HOH 8   1108 461  HOH HOH A . 
L 8 HOH 9   1109 341  HOH HOH A . 
L 8 HOH 10  1110 197  HOH HOH A . 
L 8 HOH 11  1111 189  HOH HOH A . 
L 8 HOH 12  1112 254  HOH HOH A . 
L 8 HOH 13  1113 195  HOH HOH A . 
L 8 HOH 14  1114 247  HOH HOH A . 
L 8 HOH 15  1115 217  HOH HOH A . 
L 8 HOH 16  1116 185  HOH HOH A . 
L 8 HOH 17  1117 204  HOH HOH A . 
L 8 HOH 18  1118 248  HOH HOH A . 
L 8 HOH 19  1119 133  HOH HOH A . 
L 8 HOH 20  1120 308  HOH HOH A . 
L 8 HOH 21  1121 52   HOH HOH A . 
L 8 HOH 22  1122 180  HOH HOH A . 
L 8 HOH 23  1123 374  HOH HOH A . 
L 8 HOH 24  1124 187  HOH HOH A . 
L 8 HOH 25  1125 220  HOH HOH A . 
L 8 HOH 26  1126 166  HOH HOH A . 
L 8 HOH 27  1127 152  HOH HOH A . 
L 8 HOH 28  1128 258  HOH HOH A . 
L 8 HOH 29  1129 176  HOH HOH A . 
L 8 HOH 30  1130 113  HOH HOH A . 
L 8 HOH 31  1131 266  HOH HOH A . 
L 8 HOH 32  1132 230  HOH HOH A . 
L 8 HOH 33  1133 309  HOH HOH A . 
L 8 HOH 34  1134 206  HOH HOH A . 
L 8 HOH 35  1135 182  HOH HOH A . 
L 8 HOH 36  1136 209  HOH HOH A . 
L 8 HOH 37  1137 225  HOH HOH A . 
L 8 HOH 38  1138 265  HOH HOH A . 
L 8 HOH 39  1139 292  HOH HOH A . 
L 8 HOH 40  1140 365  HOH HOH A . 
L 8 HOH 41  1141 207  HOH HOH A . 
L 8 HOH 42  1142 129  HOH HOH A . 
L 8 HOH 43  1143 312  HOH HOH A . 
L 8 HOH 44  1144 227  HOH HOH A . 
L 8 HOH 45  1145 318  HOH HOH A . 
L 8 HOH 46  1146 243  HOH HOH A . 
L 8 HOH 47  1147 300  HOH HOH A . 
L 8 HOH 48  1148 289  HOH HOH A . 
L 8 HOH 49  1149 201  HOH HOH A . 
L 8 HOH 50  1150 151  HOH HOH A . 
L 8 HOH 51  1151 25   HOH HOH A . 
L 8 HOH 52  1152 205  HOH HOH A . 
L 8 HOH 53  1153 257  HOH HOH A . 
L 8 HOH 54  1154 211  HOH HOH A . 
L 8 HOH 55  1155 34   HOH HOH A . 
L 8 HOH 56  1156 165  HOH HOH A . 
L 8 HOH 57  1157 303  HOH HOH A . 
L 8 HOH 58  1158 288  HOH HOH A . 
L 8 HOH 59  1159 277  HOH HOH A . 
L 8 HOH 60  1160 190  HOH HOH A . 
L 8 HOH 61  1161 224  HOH HOH A . 
L 8 HOH 62  1162 244  HOH HOH A . 
L 8 HOH 63  1163 281  HOH HOH A . 
L 8 HOH 64  1164 223  HOH HOH A . 
L 8 HOH 65  1165 222  HOH HOH A . 
L 8 HOH 66  1166 179  HOH HOH A . 
L 8 HOH 67  1167 274  HOH HOH A . 
L 8 HOH 68  1168 91   HOH HOH A . 
L 8 HOH 69  1169 395  HOH HOH A . 
L 8 HOH 70  1170 401  HOH HOH A . 
L 8 HOH 71  1171 178  HOH HOH A . 
L 8 HOH 72  1172 236  HOH HOH A . 
L 8 HOH 73  1173 256  HOH HOH A . 
L 8 HOH 74  1174 272  HOH HOH A . 
L 8 HOH 75  1175 58   HOH HOH A . 
L 8 HOH 76  1176 262  HOH HOH A . 
L 8 HOH 77  1177 232  HOH HOH A . 
L 8 HOH 78  1178 293  HOH HOH A . 
L 8 HOH 79  1179 198  HOH HOH A . 
L 8 HOH 80  1180 202  HOH HOH A . 
L 8 HOH 81  1181 251  HOH HOH A . 
L 8 HOH 82  1182 186  HOH HOH A . 
L 8 HOH 83  1183 269  HOH HOH A . 
L 8 HOH 84  1184 458  HOH HOH A . 
L 8 HOH 85  1185 215  HOH HOH A . 
L 8 HOH 86  1186 16   HOH HOH A . 
L 8 HOH 87  1187 234  HOH HOH A . 
L 8 HOH 88  1188 306  HOH HOH A . 
L 8 HOH 89  1189 188  HOH HOH A . 
L 8 HOH 90  1190 219  HOH HOH A . 
L 8 HOH 91  1191 333  HOH HOH A . 
L 8 HOH 92  1192 231  HOH HOH A . 
L 8 HOH 93  1193 213  HOH HOH A . 
L 8 HOH 94  1194 240  HOH HOH A . 
L 8 HOH 95  1195 245  HOH HOH A . 
L 8 HOH 96  1196 226  HOH HOH A . 
L 8 HOH 97  1197 87   HOH HOH A . 
L 8 HOH 98  1198 325  HOH HOH A . 
L 8 HOH 99  1199 27   HOH HOH A . 
L 8 HOH 100 1200 203  HOH HOH A . 
L 8 HOH 101 1201 252  HOH HOH A . 
L 8 HOH 102 1202 196  HOH HOH A . 
L 8 HOH 103 1203 83   HOH HOH A . 
L 8 HOH 104 1204 287  HOH HOH A . 
L 8 HOH 105 1205 193  HOH HOH A . 
L 8 HOH 106 1206 255  HOH HOH A . 
L 8 HOH 107 1207 319  HOH HOH A . 
L 8 HOH 108 1208 45   HOH HOH A . 
L 8 HOH 109 1209 89   HOH HOH A . 
L 8 HOH 110 1210 345  HOH HOH A . 
L 8 HOH 111 1211 250  HOH HOH A . 
L 8 HOH 112 1212 238  HOH HOH A . 
L 8 HOH 113 1213 294  HOH HOH A . 
L 8 HOH 114 1214 120  HOH HOH A . 
L 8 HOH 115 1215 184  HOH HOH A . 
L 8 HOH 116 1216 315  HOH HOH A . 
L 8 HOH 117 1217 194  HOH HOH A . 
L 8 HOH 118 1218 320  HOH HOH A . 
L 8 HOH 119 1219 210  HOH HOH A . 
L 8 HOH 120 1220 298  HOH HOH A . 
L 8 HOH 121 1221 311  HOH HOH A . 
L 8 HOH 122 1222 278  HOH HOH A . 
L 8 HOH 123 1223 285  HOH HOH A . 
L 8 HOH 124 1224 5    HOH HOH A . 
L 8 HOH 125 1225 264  HOH HOH A . 
L 8 HOH 126 1226 321  HOH HOH A . 
L 8 HOH 127 1227 350  HOH HOH A . 
L 8 HOH 128 1228 260  HOH HOH A . 
L 8 HOH 129 1229 270  HOH HOH A . 
L 8 HOH 130 1230 30   HOH HOH A . 
L 8 HOH 131 1231 339  HOH HOH A . 
L 8 HOH 132 1232 276  HOH HOH A . 
L 8 HOH 133 1233 331  HOH HOH A . 
L 8 HOH 134 1234 241  HOH HOH A . 
L 8 HOH 135 1235 235  HOH HOH A . 
L 8 HOH 136 1236 392  HOH HOH A . 
L 8 HOH 137 1237 304  HOH HOH A . 
L 8 HOH 138 1238 322  HOH HOH A . 
L 8 HOH 139 1239 127  HOH HOH A . 
L 8 HOH 140 1240 233  HOH HOH A . 
L 8 HOH 141 1241 199  HOH HOH A . 
L 8 HOH 142 1242 253  HOH HOH A . 
L 8 HOH 143 1243 389  HOH HOH A . 
L 8 HOH 144 1244 355  HOH HOH A . 
L 8 HOH 145 1245 132  HOH HOH A . 
L 8 HOH 146 1246 290  HOH HOH A . 
L 8 HOH 147 1247 148  HOH HOH A . 
L 8 HOH 148 1248 2    HOH HOH A . 
L 8 HOH 149 1249 364  HOH HOH A . 
L 8 HOH 150 1250 372  HOH HOH A . 
L 8 HOH 151 1251 316  HOH HOH A . 
L 8 HOH 152 1252 357  HOH HOH A . 
L 8 HOH 153 1253 239  HOH HOH A . 
L 8 HOH 154 1254 67   HOH HOH A . 
L 8 HOH 155 1255 323  HOH HOH A . 
L 8 HOH 156 1256 391  HOH HOH A . 
L 8 HOH 157 1257 342  HOH HOH A . 
L 8 HOH 158 1258 346  HOH HOH A . 
L 8 HOH 159 1259 279  HOH HOH A . 
L 8 HOH 160 1260 271  HOH HOH A . 
L 8 HOH 161 1261 314  HOH HOH A . 
L 8 HOH 162 1262 284  HOH HOH A . 
L 8 HOH 163 1263 307  HOH HOH A . 
L 8 HOH 164 1264 353  HOH HOH A . 
L 8 HOH 165 1265 228  HOH HOH A . 
L 8 HOH 166 1266 169  HOH HOH A . 
L 8 HOH 167 1267 467  HOH HOH A . 
L 8 HOH 168 1268 82   HOH HOH A . 
L 8 HOH 169 1269 335  HOH HOH A . 
L 8 HOH 170 1270 368  HOH HOH A . 
L 8 HOH 171 1271 237  HOH HOH A . 
L 8 HOH 172 1272 96   HOH HOH A . 
L 8 HOH 173 1273 351  HOH HOH A . 
L 8 HOH 174 1274 261  HOH HOH A . 
L 8 HOH 175 1275 136  HOH HOH A . 
L 8 HOH 176 1276 246  HOH HOH A . 
L 8 HOH 177 1277 344  HOH HOH A . 
L 8 HOH 178 1278 378  HOH HOH A . 
L 8 HOH 179 1279 81   HOH HOH A . 
L 8 HOH 180 1280 15   HOH HOH A . 
L 8 HOH 181 1281 338  HOH HOH A . 
L 8 HOH 182 1282 200  HOH HOH A . 
L 8 HOH 183 1283 48   HOH HOH A . 
L 8 HOH 184 1284 295  HOH HOH A . 
L 8 HOH 185 1285 367  HOH HOH A . 
L 8 HOH 186 1286 39   HOH HOH A . 
L 8 HOH 187 1287 4    HOH HOH A . 
L 8 HOH 188 1288 326  HOH HOH A . 
L 8 HOH 189 1289 47   HOH HOH A . 
L 8 HOH 190 1290 33   HOH HOH A . 
L 8 HOH 191 1291 32   HOH HOH A . 
L 8 HOH 192 1292 329  HOH HOH A . 
L 8 HOH 193 1293 297  HOH HOH A . 
L 8 HOH 194 1294 282  HOH HOH A . 
L 8 HOH 195 1295 42   HOH HOH A . 
L 8 HOH 196 1296 383  HOH HOH A . 
L 8 HOH 197 1297 399  HOH HOH A . 
L 8 HOH 198 1298 363  HOH HOH A . 
L 8 HOH 199 1299 330  HOH HOH A . 
L 8 HOH 200 1300 416  HOH HOH A . 
L 8 HOH 201 1301 56   HOH HOH A . 
L 8 HOH 202 1302 386  HOH HOH A . 
L 8 HOH 203 1303 40   HOH HOH A . 
L 8 HOH 204 1304 354  HOH HOH A . 
L 8 HOH 205 1305 462  HOH HOH A . 
L 8 HOH 206 1306 361  HOH HOH A . 
L 8 HOH 207 1307 369  HOH HOH A . 
L 8 HOH 208 1308 403  HOH HOH A . 
L 8 HOH 209 1309 366  HOH HOH A . 
L 8 HOH 210 1310 313  HOH HOH A . 
L 8 HOH 211 1311 70   HOH HOH A . 
L 8 HOH 212 1312 402  HOH HOH A . 
L 8 HOH 213 1313 388  HOH HOH A . 
L 8 HOH 214 1314 418  HOH HOH A . 
L 8 HOH 215 1315 381  HOH HOH A . 
L 8 HOH 216 1316 20   HOH HOH A . 
L 8 HOH 217 1317 411  HOH HOH A . 
L 8 HOH 218 1318 340  HOH HOH A . 
L 8 HOH 219 1319 347  HOH HOH A . 
L 8 HOH 220 1320 360  HOH HOH A . 
L 8 HOH 221 1321 328  HOH HOH A . 
L 8 HOH 222 1322 371  HOH HOH A . 
L 8 HOH 223 1323 393  HOH HOH A . 
L 8 HOH 224 1324 406  HOH HOH A . 
L 8 HOH 225 1325 98   HOH HOH A . 
L 8 HOH 226 1326 394  HOH HOH A . 
L 8 HOH 227 1327 14   HOH HOH A . 
L 8 HOH 228 1328 398  HOH HOH A . 
L 8 HOH 229 1329 352  HOH HOH A . 
L 8 HOH 230 1330 469  HOH HOH A . 
L 8 HOH 231 1331 80   HOH HOH A . 
L 8 HOH 232 1332 373  HOH HOH A . 
L 8 HOH 233 1333 400  HOH HOH A . 
L 8 HOH 234 1334 384  HOH HOH A . 
L 8 HOH 235 1335 109  HOH HOH A . 
L 8 HOH 236 1336 38   HOH HOH A . 
L 8 HOH 237 1337 359  HOH HOH A . 
L 8 HOH 238 1338 390  HOH HOH A . 
L 8 HOH 239 1339 379  HOH HOH A . 
L 8 HOH 240 1340 218  HOH HOH A . 
L 8 HOH 241 1341 114  HOH HOH A . 
L 8 HOH 242 1342 106  HOH HOH A . 
L 8 HOH 243 1343 459  HOH HOH A . 
L 8 HOH 244 1344 410  HOH HOH A . 
L 8 HOH 245 1345 404  HOH HOH A . 
L 8 HOH 246 1346 137  HOH HOH A . 
L 8 HOH 247 1347 1    HOH HOH A . 
L 8 HOH 248 1348 466  HOH HOH A . 
L 8 HOH 249 1349 283  HOH HOH A . 
L 8 HOH 250 1350 412  HOH HOH A . 
L 8 HOH 251 1351 422  HOH HOH A . 
L 8 HOH 252 1352 444  HOH HOH A . 
L 8 HOH 253 1353 334  HOH HOH A . 
L 8 HOH 254 1354 452  HOH HOH A . 
L 8 HOH 255 1355 337  HOH HOH A . 
L 8 HOH 256 1356 28   HOH HOH A . 
L 8 HOH 257 1357 72   HOH HOH A . 
L 8 HOH 258 1358 50   HOH HOH A . 
L 8 HOH 259 1359 181  HOH HOH A . 
L 8 HOH 260 1360 62   HOH HOH A . 
L 8 HOH 261 1361 429  HOH HOH A . 
L 8 HOH 262 1362 99   HOH HOH A . 
L 8 HOH 263 1363 63   HOH HOH A . 
L 8 HOH 264 1364 18   HOH HOH A . 
L 8 HOH 265 1365 273  HOH HOH A . 
L 8 HOH 266 1366 146  HOH HOH A . 
L 8 HOH 267 1367 415  HOH HOH A . 
L 8 HOH 268 1368 93   HOH HOH A . 
L 8 HOH 269 1369 434  HOH HOH A . 
L 8 HOH 270 1370 112  HOH HOH A . 
L 8 HOH 271 1371 439  HOH HOH A . 
L 8 HOH 272 1372 437  HOH HOH A . 
L 8 HOH 273 1373 349  HOH HOH A . 
L 8 HOH 274 1374 88   HOH HOH A . 
L 8 HOH 275 1375 433  HOH HOH A . 
L 8 HOH 276 1376 456  HOH HOH A . 
L 8 HOH 277 1377 436  HOH HOH A . 
L 8 HOH 278 1378 324  HOH HOH A . 
L 8 HOH 279 1379 123  HOH HOH A . 
L 8 HOH 280 1380 465  HOH HOH A . 
L 8 HOH 281 1381 424  HOH HOH A . 
L 8 HOH 282 1382 409  HOH HOH A . 
L 8 HOH 283 1383 208  HOH HOH A . 
L 8 HOH 284 1384 414  HOH HOH A . 
L 8 HOH 285 1385 425  HOH HOH A . 
L 8 HOH 286 1386 97   HOH HOH A . 
L 8 HOH 287 1387 428  HOH HOH A . 
L 8 HOH 288 1388 427  HOH HOH A . 
L 8 HOH 289 1389 43   HOH HOH A . 
L 8 HOH 290 1390 397  HOH HOH A . 
L 8 HOH 291 1391 430  HOH HOH A . 
L 8 HOH 292 1392 131  HOH HOH A . 
L 8 HOH 293 1393 61   HOH HOH A . 
L 8 HOH 294 1394 332  HOH HOH A . 
L 8 HOH 295 1395 435  HOH HOH A . 
L 8 HOH 296 1396 464  HOH HOH A . 
L 8 HOH 297 1397 442  HOH HOH A . 
L 8 HOH 298 1398 431  HOH HOH A . 
L 8 HOH 299 1399 438  HOH HOH A . 
L 8 HOH 300 1400 468  HOH HOH A . 
L 8 HOH 301 1401 122  HOH HOH A . 
L 8 HOH 302 1402 51   HOH HOH A . 
L 8 HOH 303 1403 426  HOH HOH A . 
L 8 HOH 304 1404 53   HOH HOH A . 
L 8 HOH 305 1405 445  HOH HOH A . 
L 8 HOH 306 1406 8    HOH HOH A . 
L 8 HOH 307 1407 78   HOH HOH A . 
L 8 HOH 308 1408 55   HOH HOH A . 
L 8 HOH 309 1409 441  HOH HOH A . 
L 8 HOH 310 1410 121  HOH HOH A . 
L 8 HOH 311 1411 301  HOH HOH A . 
L 8 HOH 312 1412 118  HOH HOH A . 
L 8 HOH 313 1413 447  HOH HOH A . 
L 8 HOH 314 1414 455  HOH HOH A . 
L 8 HOH 315 1415 49   HOH HOH A . 
L 8 HOH 316 1416 135  HOH HOH A . 
L 8 HOH 317 1417 453  HOH HOH A . 
L 8 HOH 318 1418 95   HOH HOH A . 
L 8 HOH 319 1419 17   HOH HOH A . 
L 8 HOH 320 1420 440  HOH HOH A . 
L 8 HOH 321 1421 443  HOH HOH A . 
L 8 HOH 322 1422 73   HOH HOH A . 
L 8 HOH 323 1423 450  HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A THR 344 ? CB  ? A THR 81 CB  
2 1 Y 1 A THR 344 ? OG1 ? A THR 81 OG1 
3 1 Y 1 A THR 344 ? CG2 ? A THR 81 CG2 
# 
loop_
_software.classification 
_software.name 
_software.version 
_software.citation_id 
_software.pdbx_ordinal 
_software.date 
_software.type 
_software.location 
_software.language 
refinement       REFMAC  5.8.0267 ? 1 ? ? ? ? 
'data scaling'   Aimless .        ? 2 ? ? ? ? 
phasing          PHASER  .        ? 3 ? ? ? ? 
'data reduction' XDS     .        ? 4 ? ? ? ? 
# 
_cell.entry_id           7I2O 
_cell.length_a           82.449 
_cell.length_b           116.263 
_cell.length_c           146.908 
_cell.angle_alpha        90.00 
_cell.angle_beta         90.00 
_cell.angle_gamma        90.00 
_cell.Z_PDB              8 
_cell.pdbx_unique_axis   ? 
# 
_symmetry.entry_id                         7I2O 
_symmetry.space_group_name_H-M             'I 2 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                23 
# 
_exptl.entry_id          7I2O 
_exptl.method            'X-RAY DIFFRACTION' 
_exptl.crystals_number   1 
# 
_exptl_crystal.id                    1 
_exptl_crystal.density_meas          ? 
_exptl_crystal.density_Matthews      2.38 
_exptl_crystal.density_percent_sol   48.37 
_exptl_crystal.description           ? 
_exptl_crystal.preparation           ? 
# 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.temp            293.15 
_exptl_crystal_grow.pdbx_details    '350 mM Magnesium chloride, 10% PEG 4000, 100 mM MES, pH 6.5' 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.pdbx_pH_range   ? 
# 
_diffrn.id                               1 
_diffrn.ambient_temp                     100 
_diffrn.crystal_id                       1 
_diffrn.ambient_temp_details             ? 
_diffrn.pdbx_serial_crystal_experiment   ? 
# 
_diffrn_detector.detector               PIXEL 
_diffrn_detector.type                   'DECTRIS EIGER2 XE 9M' 
_diffrn_detector.pdbx_collection_date   2023-11-30 
_diffrn_detector.diffrn_id              1 
_diffrn_detector.details                ? 
# 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.92124 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.diffrn_id                   1 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.type                        'DIAMOND BEAMLINE I04-1' 
_diffrn_source.pdbx_wavelength_list        0.92124 
_diffrn_source.pdbx_synchrotron_site       Diamond 
_diffrn_source.pdbx_synchrotron_beamline   I04-1 
_diffrn_source.pdbx_wavelength             ? 
# 
_reflns.entry_id                     7I2O 
_reflns.pdbx_diffrn_id               1 
_reflns.pdbx_ordinal                 1 
_reflns.d_resolution_low             73.47 
_reflns.d_resolution_high            1.86 
_reflns.number_obs                   59483 
_reflns.percent_possible_obs         100.0 
_reflns.pdbx_Rmerge_I_obs            0.168 
_reflns.pdbx_netI_over_sigmaI        9.0 
_reflns.pdbx_redundancy              13.7 
_reflns.pdbx_Rrim_I_all              0.175 
_reflns.pdbx_Rpim_I_all              0.047 
_reflns.pdbx_CC_half                 0.999 
_reflns.pdbx_number_measured_all     813834 
_reflns.pdbx_chi_squared             0.35 
_reflns.observed_criterion_sigma_I   ? 
_reflns.observed_criterion_sigma_F   ? 
_reflns.number_all                   ? 
_reflns.pdbx_Rsym_value              ? 
_reflns.B_iso_Wilson_estimate        ? 
_reflns.pdbx_CC_star                 ? 
# 
_reflns_shell.pdbx_diffrn_id              1 
_reflns_shell.pdbx_ordinal                1 
_reflns_shell.d_res_high                  1.86 
_reflns_shell.d_res_low                   1.90 
_reflns_shell.number_measured_all         50270 
_reflns_shell.number_unique_obs           3631 
_reflns_shell.Rmerge_I_obs                5.582 
_reflns_shell.pdbx_chi_squared            0.14 
_reflns_shell.pdbx_redundancy             13.8 
_reflns_shell.percent_possible_obs        99.4 
_reflns_shell.pdbx_netI_over_sigmaI_obs   0.3 
_reflns_shell.pdbx_Rrim_I_all             5.795 
_reflns_shell.pdbx_Rpim_I_all             1.549 
_reflns_shell.pdbx_CC_half                0.362 
_reflns_shell.percent_possible_all        ? 
_reflns_shell.pdbx_Rsym_value             ? 
_reflns_shell.meanI_over_sigI_obs         ? 
_reflns_shell.number_measured_obs         ? 
_reflns_shell.number_unique_all           ? 
_reflns_shell.pdbx_CC_star                ? 
# 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.entry_id                                 7I2O 
_refine.pdbx_diffrn_id                           1 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     54867 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             73.47 
_refine.ls_d_res_high                            1.86 
_refine.ls_percent_reflns_obs                    97.19 
_refine.ls_R_factor_obs                          0.19911 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       0.19658 
_refine.ls_R_factor_R_free                       0.24431 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 5.2 
_refine.ls_number_reflns_R_free                  2980 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               0.964 
_refine.correlation_coeff_Fo_to_Fc_free          0.950 
_refine.B_iso_mean                               65.191 
_refine.aniso_B[1][1]                            -2.80 
_refine.aniso_B[2][2]                            0.23 
_refine.aniso_B[3][3]                            2.57 
_refine.aniso_B[1][2]                            -0.00 
_refine.aniso_B[1][3]                            0.00 
_refine.aniso_B[2][3]                            -0.00 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_overall_ESU_R                       0.360 
_refine.pdbx_overall_ESU_R_Free                  0.207 
_refine.overall_SU_ML                            0.281 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             11.131 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.pdbx_number_atoms_protein        4671 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         58 
_refine_hist.number_atoms_solvent             323 
_refine_hist.number_atoms_total               5052 
_refine_hist.d_res_high                       1.86 
_refine_hist.d_res_low                        73.47 
# 
loop_
_refine_ls_restr.type 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.weight 
_refine_ls_restr.number 
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.pdbx_restraint_function 
r_bond_refined_d             0.006  0.015  ? 14478 'X-RAY DIFFRACTION' ? 
r_bond_other_d               0.001  0.015  ? 9802  'X-RAY DIFFRACTION' ? 
r_angle_refined_deg          1.380  1.646  ? 14325 'X-RAY DIFFRACTION' ? 
r_angle_other_deg            1.180  1.595  ? 22746 'X-RAY DIFFRACTION' ? 
r_dihedral_angle_1_deg       5.904  5.000  ? 1375  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_2_deg       31.454 21.456 ? 618   'X-RAY DIFFRACTION' ? 
r_dihedral_angle_3_deg       16.268 15.000 ? 1958  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_4_deg       15.978 15.000 ? 98    'X-RAY DIFFRACTION' ? 
r_chiral_restr               0.061  0.200  ? 1281  'X-RAY DIFFRACTION' ? 
r_gen_planes_refined         0.006  0.020  ? 12644 'X-RAY DIFFRACTION' ? 
r_gen_planes_other           0.002  0.020  ? 2636  'X-RAY DIFFRACTION' ? 
r_nbd_refined                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbd_other                  ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_refined              ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_other                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_refined        ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_other          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_refined          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_other            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_refined       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_other         ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_refined     ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_other       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_refined ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_other   ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_mcbond_it                  3.132  6.492  ? 7005  'X-RAY DIFFRACTION' ? 
r_mcbond_other               3.178  6.513  ? 6802  'X-RAY DIFFRACTION' ? 
r_mcangle_it                 5.969  9.331  ? 6529  'X-RAY DIFFRACTION' ? 
r_mcangle_other              5.969  9.331  ? 6530  'X-RAY DIFFRACTION' ? 
r_scbond_it                  3.284  7.262  ? 7473  'X-RAY DIFFRACTION' ? 
r_scbond_other               3.284  7.262  ? 7474  'X-RAY DIFFRACTION' ? 
r_scangle_it                 ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_scangle_other              5.904  10.410 ? 7797  'X-RAY DIFFRACTION' ? 
r_long_range_B_refined       9.776  53.470 ? 10023 'X-RAY DIFFRACTION' ? 
r_long_range_B_other         9.649  53.100 ? 9874  'X-RAY DIFFRACTION' ? 
r_rigid_bond_restr           ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_free            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_bonded          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.d_res_high                       1.860 
_refine_ls_shell.d_res_low                        1.909 
_refine_ls_shell.number_reflns_R_work             2883 
_refine_ls_shell.R_factor_R_work                  0.429 
_refine_ls_shell.percent_reflns_obs               70.13 
_refine_ls_shell.R_factor_R_free                  0.471 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.number_reflns_R_free             165 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.number_reflns_obs                ? 
# 
_struct.entry_id                  7I2O 
_struct.title                     
;Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z1787627869 (DNV2_NS5A-x0587)
;
_struct.pdbx_model_details        ? 
_struct.pdbx_CASP_flag            ? 
_struct.pdbx_model_type_details   ? 
# 
_struct_keywords.entry_id        7I2O 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
_struct_keywords.text            
;Diamond Light Source, I04-1, READDI, Dengue Virus, crystallographic fragment screening, PanDDA, XChemExplorer, cluster4x, VIRAL PROTEIN
;
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 4 ? 
H N N 5 ? 
I N N 5 ? 
J N N 6 ? 
K N N 7 ? 
L N N 8 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q91H74_9FLAV 
_struct_ref.pdbx_db_accession          Q91H74 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;GIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAMTD
TTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAREA
VEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLS
GVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRPTP
RGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGDDC
VVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQGAG
WSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPWME
DKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_struct_ref.pdbx_align_begin           2757 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              7I2O 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 3 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 637 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q91H74 
_struct_ref_seq.db_align_beg                  2757 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3391 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       266 
_struct_ref_seq.pdbx_auth_seq_align_end       900 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 7I2O GLY A 1 ? UNP Q91H74 ? ? 'expression tag' 264 1 
1 7I2O PRO A 2 ? UNP Q91H74 ? ? 'expression tag' 265 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 10  ? GLU A 24  ? ASN A 273 GLU A 287 1 ? 15 
HELX_P HELX_P2  AA2 HIS A 25  ? TRP A 29  ? HIS A 288 TRP A 292 5 ? 5  
HELX_P HELX_P3  AA3 ASN A 59  ? LEU A 65  ? ASN A 322 LEU A 328 1 ? 7  
HELX_P HELX_P4  AA4 THR A 66  ? ILE A 71  ? THR A 329 ILE A 334 5 ? 6  
HELX_P HELX_P5  AA5 ILE A 72  ? GLN A 77  ? ILE A 335 GLN A 340 1 ? 6  
HELX_P HELX_P6  AA6 MET A 78  ? MET A 80  ? MET A 341 MET A 343 5 ? 3  
HELX_P HELX_P7  AA7 LYS A 104 ? LYS A 124 ? LYS A 367 LYS A 387 1 ? 21 
HELX_P HELX_P8  AA8 THR A 132 ? ARG A 141 ? THR A 395 ARG A 404 1 ? 10 
HELX_P HELX_P9  AA9 SER A 158 ? GLU A 164 ? SER A 421 GLU A 427 1 ? 7  
HELX_P HELX_P10 AB1 ASP A 165 ? GLU A 181 ? ASP A 428 GLU A 444 1 ? 17 
HELX_P HELX_P11 AB2 TRP A 215 ? GLY A 227 ? TRP A 478 GLY A 490 1 ? 13 
HELX_P HELX_P12 AB3 GLY A 227 ? ASP A 232 ? GLY A 490 ASP A 495 1 ? 6  
HELX_P HELX_P13 AB4 SER A 236 ? LEU A 241 ? SER A 499 LEU A 504 1 ? 6  
HELX_P HELX_P14 AB5 LYS A 251 ? LYS A 261 ? LYS A 514 LYS A 524 1 ? 11 
HELX_P HELX_P15 AB6 GLY A 274 ? ILE A 279 ? GLY A 537 ILE A 542 5 ? 6  
HELX_P HELX_P16 AB7 THR A 280 ? MET A 289 ? THR A 543 MET A 552 1 ? 10 
HELX_P HELX_P17 AB8 VAL A 290 ? MET A 294 ? VAL A 553 MET A 557 5 ? 5  
HELX_P HELX_P18 AB9 GLU A 295 ? TYR A 310 ? GLU A 558 TYR A 573 1 ? 16 
HELX_P HELX_P19 AC1 GLY A 339 ? GLU A 363 ? GLY A 602 GLU A 626 1 ? 25 
HELX_P HELX_P20 AC2 THR A 373 ? SER A 393 ? THR A 636 SER A 656 1 ? 21 
HELX_P HELX_P21 AC3 ASP A 408 ? ALA A 414 ? ASP A 671 ALA A 677 5 ? 7  
HELX_P HELX_P22 AC4 LEU A 415 ? MET A 421 ? LEU A 678 MET A 684 1 ? 7  
HELX_P HELX_P23 AC5 ASN A 467 ? ARG A 476 ? ASN A 730 ARG A 739 1 ? 10 
HELX_P HELX_P24 AC6 SER A 484 ? TYR A 503 ? SER A 747 TYR A 766 1 ? 20 
HELX_P HELX_P25 AC7 ARG A 506 ? VAL A 520 ? ARG A 769 VAL A 783 1 ? 15 
HELX_P HELX_P26 AC8 ASP A 545 ? ILE A 555 ? ASP A 808 ILE A 818 1 ? 11 
HELX_P HELX_P27 AC9 SER A 569 ? ILE A 573 ? SER A 832 ILE A 836 5 ? 5  
HELX_P HELX_P28 AD1 GLY A 577 ? CYS A 584 ? GLY A 840 CYS A 847 1 ? 8  
HELX_P HELX_P29 AD2 LEU A 590 ? ASN A 599 ? LEU A 853 ASN A 862 1 ? 10 
HELX_P HELX_P30 AD3 ASN A 599 ? GLY A 612 ? ASN A 862 GLY A 875 1 ? 14 
HELX_P HELX_P31 AD4 TYR A 619 ? MET A 623 ? TYR A 882 MET A 886 5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A GLU 175 OE1 ? ? ? 1_555 C ZN . ZN ? ? A GLU 438 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.067 ? ? 
metalc2 metalc ? ? A HIS 179 NE2 ? ? ? 1_555 C ZN . ZN ? ? A HIS 442 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.081 ? ? 
metalc3 metalc ? ? A CYS 184 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 447 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.265 ? ? 
metalc4 metalc ? ? A CYS 187 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 450 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.171 ? ? 
metalc5 metalc ? ? A HIS 449 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 712 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.137 ? ? 
metalc6 metalc ? ? A HIS 451 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 714 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.000 ? ? 
metalc7 metalc ? ? A CYS 465 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 728 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.366 ? ? 
metalc8 metalc ? ? A CYS 584 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 847 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.355 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 NE2 ? A HIS 179 ? A HIS 442 ? 1_555 88.1  ? 
2  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 136.3 ? 
3  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 118.5 ? 
4  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 82.8  ? 
5  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 115.0 ? 
6  SG  ? A CYS 184 ? A CYS 447 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 111.2 ? 
7  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 100.8 ? 
8  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 108.0 ? 
9  NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 106.3 ? 
10 NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 103.3 ? 
11 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 118.2 ? 
12 SG  ? A CYS 465 ? A CYS 728 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 118.3 ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 41  ? GLY A 44  ? ALA A 304 GLY A 307 
AA1 2 VAL A 326 ? ARG A 332 ? VAL A 589 ARG A 595 
AA1 3 LYS A 313 ? ARG A 319 ? LYS A 576 ARG A 582 
AA1 4 TYR A 189 ? ASN A 190 ? TYR A 452 ASN A 453 
AA2 1 MET A 57  ? VAL A 58  ? MET A 320 VAL A 321 
AA2 2 ILE A 477 ? SER A 478 ? ILE A 740 SER A 741 
AA3 1 MET A 395 ? SER A 398 ? MET A 658 SER A 661 
AA3 2 ASP A 401 ? VAL A 404 ? ASP A 664 VAL A 667 
AA4 1 HIS A 449 ? ILE A 454 ? HIS A 712 ILE A 717 
AA4 2 VAL A 460 ? CYS A 465 ? VAL A 723 CYS A 728 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ALA A 41  ? N ALA A 304 O SER A 331 ? O SER A 594 
AA1 2 3 O VAL A 326 ? O VAL A 589 N ARG A 319 ? N ARG A 582 
AA1 3 4 O VAL A 314 ? O VAL A 577 N TYR A 189 ? N TYR A 452 
AA2 1 2 N MET A 57  ? N MET A 320 O SER A 478 ? O SER A 741 
AA3 1 2 N SER A 398 ? N SER A 661 O ASP A 401 ? O ASP A 664 
AA4 1 2 N LEU A 453 ? N LEU A 716 O LEU A 461 ? O LEU A 724 
# 
_pdbx_entry_details.entry_id                   7I2O 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   OD1 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   ASP 
_pdbx_validate_close_contact.auth_seq_id_1    664 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O4 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   PO4 
_pdbx_validate_close_contact.auth_seq_id_2    1007 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.00 
# 
loop_
_pdbx_validate_symm_contact.id 
_pdbx_validate_symm_contact.PDB_model_num 
_pdbx_validate_symm_contact.auth_atom_id_1 
_pdbx_validate_symm_contact.auth_asym_id_1 
_pdbx_validate_symm_contact.auth_comp_id_1 
_pdbx_validate_symm_contact.auth_seq_id_1 
_pdbx_validate_symm_contact.PDB_ins_code_1 
_pdbx_validate_symm_contact.label_alt_id_1 
_pdbx_validate_symm_contact.site_symmetry_1 
_pdbx_validate_symm_contact.auth_atom_id_2 
_pdbx_validate_symm_contact.auth_asym_id_2 
_pdbx_validate_symm_contact.auth_comp_id_2 
_pdbx_validate_symm_contact.auth_seq_id_2 
_pdbx_validate_symm_contact.PDB_ins_code_2 
_pdbx_validate_symm_contact.label_alt_id_2 
_pdbx_validate_symm_contact.site_symmetry_2 
_pdbx_validate_symm_contact.dist 
1 1 O A HOH 1122 ? ? 1_555 O A HOH 1122 ? ? 2_445 1.79 
2 1 O A HOH 1262 ? ? 1_555 O A HOH 1344 ? ? 2_545 1.89 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 HIS A 288 ? ? -141.15 32.85  
2  1 ASP A 297 ? ? -114.38 57.80  
3  1 ASN A 406 ? ? 62.06   115.21 
4  1 LEU A 409 ? ? -150.38 50.87  
5  1 LYS A 420 ? ? -66.71  -84.37 
6  1 LEU A 504 ? ? 79.15   -41.07 
7  1 VAL A 507 ? ? -141.50 21.35  
8  1 ASN A 575 ? ? -166.69 68.50  
9  1 ARG A 595 ? ? 177.90  157.29 
10 1 GLN A 598 ? ? 71.04   169.65 
11 1 SER A 791 ? ? -160.52 116.28 
12 1 HIS A 801 ? A -104.72 77.35  
13 1 HIS A 801 ? B -104.00 77.74  
14 1 ILE A 818 ? ? -122.07 -68.46 
# 
loop_
_pdbx_validate_main_chain_plane.id 
_pdbx_validate_main_chain_plane.PDB_model_num 
_pdbx_validate_main_chain_plane.auth_comp_id 
_pdbx_validate_main_chain_plane.auth_asym_id 
_pdbx_validate_main_chain_plane.auth_seq_id 
_pdbx_validate_main_chain_plane.PDB_ins_code 
_pdbx_validate_main_chain_plane.label_alt_id 
_pdbx_validate_main_chain_plane.improper_torsion_angle 
1 1 GLY A 511 ? ? -10.44 
2 1 GLY A 511 ? ? -10.17 
3 1 LEU A 512 ? B 11.15  
4 1 THR A 800 ? ? 11.20  
5 1 THR A 800 ? ? 11.47  
6 1 HIS A 801 ? A -10.14 
7 1 HIS A 801 ? B -10.24 
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A MES 1003 ? D MES . 
2 1 A HOH 1154 ? L HOH . 
3 1 A HOH 1192 ? L HOH . 
4 1 A HOH 1394 ? L HOH . 
5 1 A HOH 1399 ? L HOH . 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 1422 ? 5.99 . 
2 1 O ? A HOH 1423 ? 6.00 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 264 ? A GLY 1   
2  1 Y 1 A PRO 265 ? A PRO 2   
3  1 Y 1 A GLY 266 ? A GLY 3   
4  1 Y 1 A ILE 267 ? A ILE 4   
5  1 Y 1 A GLU 268 ? A GLU 5   
6  1 Y 1 A SER 269 ? A SER 6   
7  1 Y 1 A GLU 270 ? A GLU 7   
8  1 Y 1 A THR 271 ? A THR 8   
9  1 Y 1 A PRO 272 ? A PRO 9   
10 1 Y 1 A GLN 313 ? A GLN 50  
11 1 Y 1 A THR 314 ? A THR 51  
12 1 Y 1 A GLY 315 ? A GLY 52  
13 1 Y 1 A SER 316 ? A SER 53  
14 1 Y 1 A ALA 317 ? A ALA 54  
15 1 Y 1 A ASP 345 ? A ASP 82  
16 1 Y 1 A THR 346 ? A THR 83  
17 1 Y 1 A THR 347 ? A THR 84  
18 1 Y 1 A PRO 348 ? A PRO 85  
19 1 Y 1 A PHE 349 ? A PHE 86  
20 1 Y 1 A GLY 350 ? A GLY 87  
21 1 Y 1 A GLN 351 ? A GLN 88  
22 1 Y 1 A GLN 352 ? A GLN 89  
23 1 Y 1 A ARG 353 ? A ARG 90  
24 1 Y 1 A VAL 354 ? A VAL 91  
25 1 Y 1 A PHE 355 ? A PHE 92  
26 1 Y 1 A ALA 411 ? A ALA 148 
27 1 Y 1 A ILE 412 ? A ILE 149 
28 1 Y 1 A PHE 413 ? A PHE 150 
29 1 Y 1 A THR 414 ? A THR 151 
30 1 Y 1 A ASP 415 ? A ASP 152 
31 1 Y 1 A GLU 416 ? A GLU 153 
32 1 Y 1 A ASN 417 ? A ASN 154 
33 1 Y 1 A GLY 456 ? A GLY 193 
34 1 Y 1 A LYS 457 ? A LYS 194 
35 1 Y 1 A ARG 458 ? A ARG 195 
36 1 Y 1 A GLU 459 ? A GLU 196 
37 1 Y 1 A LYS 460 ? A LYS 197 
38 1 Y 1 A LYS 461 ? A LYS 198 
39 1 Y 1 A LEU 462 ? A LEU 199 
40 1 Y 1 A GLY 463 ? A GLY 200 
41 1 Y 1 A GLU 464 ? A GLU 201 
42 1 Y 1 A PHE 465 ? A PHE 202 
43 1 Y 1 A GLY 466 ? A GLY 203 
44 1 Y 1 A LYS 467 ? A LYS 204 
45 1 Y 1 A ALA 468 ? A ALA 205 
46 1 Y 1 A LYS 469 ? A LYS 206 
47 1 Y 1 A GLY 470 ? A GLY 207 
48 1 Y 1 A SER 471 ? A SER 208 
49 1 Y 1 A ARG 472 ? A ARG 209 
50 1 Y 1 A PRO 585 ? A PRO 322 
51 1 Y 1 A ARG 586 ? A ARG 323 
52 1 Y 1 A GLY 587 ? A GLY 324 
53 1 Y 1 A THR 794 ? A THR 531 
54 1 Y 1 A TRP 795 ? A TRP 532 
55 1 Y 1 A SER 796 ? A SER 533 
56 1 Y 1 A ILE 797 ? A ILE 534 
57 1 Y 1 A HIS 798 ? A HIS 535 
58 1 Y 1 A GLU 892 ? A GLU 629 
59 1 Y 1 A GLU 893 ? A GLU 630 
60 1 Y 1 A GLU 894 ? A GLU 631 
61 1 Y 1 A GLU 895 ? A GLU 632 
62 1 Y 1 A ALA 896 ? A ALA 633 
63 1 Y 1 A GLY 897 ? A GLY 634 
64 1 Y 1 A VAL 898 ? A VAL 635 
65 1 Y 1 A LEU 899 ? A LEU 636 
66 1 Y 1 A TRP 900 ? A TRP 637 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
DMS S    S  N N 88  
DMS O    O  N N 89  
DMS C1   C  N N 90  
DMS C2   C  N N 91  
DMS H11  H  N N 92  
DMS H12  H  N N 93  
DMS H13  H  N N 94  
DMS H21  H  N N 95  
DMS H22  H  N N 96  
DMS H23  H  N N 97  
GLN N    N  N N 98  
GLN CA   C  N S 99  
GLN C    C  N N 100 
GLN O    O  N N 101 
GLN CB   C  N N 102 
GLN CG   C  N N 103 
GLN CD   C  N N 104 
GLN OE1  O  N N 105 
GLN NE2  N  N N 106 
GLN OXT  O  N N 107 
GLN H    H  N N 108 
GLN H2   H  N N 109 
GLN HA   H  N N 110 
GLN HB2  H  N N 111 
GLN HB3  H  N N 112 
GLN HG2  H  N N 113 
GLN HG3  H  N N 114 
GLN HE21 H  N N 115 
GLN HE22 H  N N 116 
GLN HXT  H  N N 117 
GLU N    N  N N 118 
GLU CA   C  N S 119 
GLU C    C  N N 120 
GLU O    O  N N 121 
GLU CB   C  N N 122 
GLU CG   C  N N 123 
GLU CD   C  N N 124 
GLU OE1  O  N N 125 
GLU OE2  O  N N 126 
GLU OXT  O  N N 127 
GLU H    H  N N 128 
GLU H2   H  N N 129 
GLU HA   H  N N 130 
GLU HB2  H  N N 131 
GLU HB3  H  N N 132 
GLU HG2  H  N N 133 
GLU HG3  H  N N 134 
GLU HE2  H  N N 135 
GLU HXT  H  N N 136 
GLY N    N  N N 137 
GLY CA   C  N N 138 
GLY C    C  N N 139 
GLY O    O  N N 140 
GLY OXT  O  N N 141 
GLY H    H  N N 142 
GLY H2   H  N N 143 
GLY HA2  H  N N 144 
GLY HA3  H  N N 145 
GLY HXT  H  N N 146 
HIS N    N  N N 147 
HIS CA   C  N S 148 
HIS C    C  N N 149 
HIS O    O  N N 150 
HIS CB   C  N N 151 
HIS CG   C  Y N 152 
HIS ND1  N  Y N 153 
HIS CD2  C  Y N 154 
HIS CE1  C  Y N 155 
HIS NE2  N  Y N 156 
HIS OXT  O  N N 157 
HIS H    H  N N 158 
HIS H2   H  N N 159 
HIS HA   H  N N 160 
HIS HB2  H  N N 161 
HIS HB3  H  N N 162 
HIS HD1  H  N N 163 
HIS HD2  H  N N 164 
HIS HE1  H  N N 165 
HIS HE2  H  N N 166 
HIS HXT  H  N N 167 
HOH O    O  N N 168 
HOH H1   H  N N 169 
HOH H2   H  N N 170 
ILE N    N  N N 171 
ILE CA   C  N S 172 
ILE C    C  N N 173 
ILE O    O  N N 174 
ILE CB   C  N S 175 
ILE CG1  C  N N 176 
ILE CG2  C  N N 177 
ILE CD1  C  N N 178 
ILE OXT  O  N N 179 
ILE H    H  N N 180 
ILE H2   H  N N 181 
ILE HA   H  N N 182 
ILE HB   H  N N 183 
ILE HG12 H  N N 184 
ILE HG13 H  N N 185 
ILE HG21 H  N N 186 
ILE HG22 H  N N 187 
ILE HG23 H  N N 188 
ILE HD11 H  N N 189 
ILE HD12 H  N N 190 
ILE HD13 H  N N 191 
ILE HXT  H  N N 192 
K07 N1   N  Y N 193 
K07 C4   C  N N 194 
K07 C5   C  N N 195 
K07 C6   C  Y N 196 
K07 C7   C  Y N 197 
K07 C8   C  Y N 198 
K07 N    N  N N 199 
K07 C    C  N N 200 
K07 O    O  N N 201 
K07 C1   C  N N 202 
K07 C2   C  N R 203 
K07 C3   C  N N 204 
K07 C9   C  Y N 205 
K07 N2   N  Y N 206 
K07 CL   CL N N 207 
K07 H1   H  N N 208 
K07 H2   H  N N 209 
K07 H3   H  N N 210 
K07 H4   H  N N 211 
K07 H5   H  N N 212 
K07 H6   H  N N 213 
K07 H7   H  N N 214 
K07 H8   H  N N 215 
K07 H9   H  N N 216 
K07 H10  H  N N 217 
K07 H11  H  N N 218 
K07 H12  H  N N 219 
K07 H13  H  N N 220 
K07 H14  H  N N 221 
LEU N    N  N N 222 
LEU CA   C  N S 223 
LEU C    C  N N 224 
LEU O    O  N N 225 
LEU CB   C  N N 226 
LEU CG   C  N N 227 
LEU CD1  C  N N 228 
LEU CD2  C  N N 229 
LEU OXT  O  N N 230 
LEU H    H  N N 231 
LEU H2   H  N N 232 
LEU HA   H  N N 233 
LEU HB2  H  N N 234 
LEU HB3  H  N N 235 
LEU HG   H  N N 236 
LEU HD11 H  N N 237 
LEU HD12 H  N N 238 
LEU HD13 H  N N 239 
LEU HD21 H  N N 240 
LEU HD22 H  N N 241 
LEU HD23 H  N N 242 
LEU HXT  H  N N 243 
LYS N    N  N N 244 
LYS CA   C  N S 245 
LYS C    C  N N 246 
LYS O    O  N N 247 
LYS CB   C  N N 248 
LYS CG   C  N N 249 
LYS CD   C  N N 250 
LYS CE   C  N N 251 
LYS NZ   N  N N 252 
LYS OXT  O  N N 253 
LYS H    H  N N 254 
LYS H2   H  N N 255 
LYS HA   H  N N 256 
LYS HB2  H  N N 257 
LYS HB3  H  N N 258 
LYS HG2  H  N N 259 
LYS HG3  H  N N 260 
LYS HD2  H  N N 261 
LYS HD3  H  N N 262 
LYS HE2  H  N N 263 
LYS HE3  H  N N 264 
LYS HZ1  H  N N 265 
LYS HZ2  H  N N 266 
LYS HZ3  H  N N 267 
LYS HXT  H  N N 268 
MES O1   O  N N 269 
MES C2   C  N N 270 
MES C3   C  N N 271 
MES N4   N  N N 272 
MES C5   C  N N 273 
MES C6   C  N N 274 
MES C7   C  N N 275 
MES C8   C  N N 276 
MES S    S  N N 277 
MES O1S  O  N N 278 
MES O2S  O  N N 279 
MES O3S  O  N N 280 
MES H21  H  N N 281 
MES H22  H  N N 282 
MES H31  H  N N 283 
MES H32  H  N N 284 
MES HN4  H  N N 285 
MES H51  H  N N 286 
MES H52  H  N N 287 
MES H61  H  N N 288 
MES H62  H  N N 289 
MES H71  H  N N 290 
MES H72  H  N N 291 
MES H81  H  N N 292 
MES H82  H  N N 293 
MET N    N  N N 294 
MET CA   C  N S 295 
MET C    C  N N 296 
MET O    O  N N 297 
MET CB   C  N N 298 
MET CG   C  N N 299 
MET SD   S  N N 300 
MET CE   C  N N 301 
MET OXT  O  N N 302 
MET H    H  N N 303 
MET H2   H  N N 304 
MET HA   H  N N 305 
MET HB2  H  N N 306 
MET HB3  H  N N 307 
MET HG2  H  N N 308 
MET HG3  H  N N 309 
MET HE1  H  N N 310 
MET HE2  H  N N 311 
MET HE3  H  N N 312 
MET HXT  H  N N 313 
PEG C1   C  N N 314 
PEG O1   O  N N 315 
PEG C2   C  N N 316 
PEG O2   O  N N 317 
PEG C3   C  N N 318 
PEG C4   C  N N 319 
PEG O4   O  N N 320 
PEG H11  H  N N 321 
PEG H12  H  N N 322 
PEG HO1  H  N N 323 
PEG H21  H  N N 324 
PEG H22  H  N N 325 
PEG H31  H  N N 326 
PEG H32  H  N N 327 
PEG H41  H  N N 328 
PEG H42  H  N N 329 
PEG HO4  H  N N 330 
PHE N    N  N N 331 
PHE CA   C  N S 332 
PHE C    C  N N 333 
PHE O    O  N N 334 
PHE CB   C  N N 335 
PHE CG   C  Y N 336 
PHE CD1  C  Y N 337 
PHE CD2  C  Y N 338 
PHE CE1  C  Y N 339 
PHE CE2  C  Y N 340 
PHE CZ   C  Y N 341 
PHE OXT  O  N N 342 
PHE H    H  N N 343 
PHE H2   H  N N 344 
PHE HA   H  N N 345 
PHE HB2  H  N N 346 
PHE HB3  H  N N 347 
PHE HD1  H  N N 348 
PHE HD2  H  N N 349 
PHE HE1  H  N N 350 
PHE HE2  H  N N 351 
PHE HZ   H  N N 352 
PHE HXT  H  N N 353 
PO4 P    P  N N 354 
PO4 O1   O  N N 355 
PO4 O2   O  N N 356 
PO4 O3   O  N N 357 
PO4 O4   O  N N 358 
PRO N    N  N N 359 
PRO CA   C  N S 360 
PRO C    C  N N 361 
PRO O    O  N N 362 
PRO CB   C  N N 363 
PRO CG   C  N N 364 
PRO CD   C  N N 365 
PRO OXT  O  N N 366 
PRO H    H  N N 367 
PRO HA   H  N N 368 
PRO HB2  H  N N 369 
PRO HB3  H  N N 370 
PRO HG2  H  N N 371 
PRO HG3  H  N N 372 
PRO HD2  H  N N 373 
PRO HD3  H  N N 374 
PRO HXT  H  N N 375 
SER N    N  N N 376 
SER CA   C  N S 377 
SER C    C  N N 378 
SER O    O  N N 379 
SER CB   C  N N 380 
SER OG   O  N N 381 
SER OXT  O  N N 382 
SER H    H  N N 383 
SER H2   H  N N 384 
SER HA   H  N N 385 
SER HB2  H  N N 386 
SER HB3  H  N N 387 
SER HG   H  N N 388 
SER HXT  H  N N 389 
THR N    N  N N 390 
THR CA   C  N S 391 
THR C    C  N N 392 
THR O    O  N N 393 
THR CB   C  N R 394 
THR OG1  O  N N 395 
THR CG2  C  N N 396 
THR OXT  O  N N 397 
THR H    H  N N 398 
THR H2   H  N N 399 
THR HA   H  N N 400 
THR HB   H  N N 401 
THR HG1  H  N N 402 
THR HG21 H  N N 403 
THR HG22 H  N N 404 
THR HG23 H  N N 405 
THR HXT  H  N N 406 
TRP N    N  N N 407 
TRP CA   C  N S 408 
TRP C    C  N N 409 
TRP O    O  N N 410 
TRP CB   C  N N 411 
TRP CG   C  Y N 412 
TRP CD1  C  Y N 413 
TRP CD2  C  Y N 414 
TRP NE1  N  Y N 415 
TRP CE2  C  Y N 416 
TRP CE3  C  Y N 417 
TRP CZ2  C  Y N 418 
TRP CZ3  C  Y N 419 
TRP CH2  C  Y N 420 
TRP OXT  O  N N 421 
TRP H    H  N N 422 
TRP H2   H  N N 423 
TRP HA   H  N N 424 
TRP HB2  H  N N 425 
TRP HB3  H  N N 426 
TRP HD1  H  N N 427 
TRP HE1  H  N N 428 
TRP HE3  H  N N 429 
TRP HZ2  H  N N 430 
TRP HZ3  H  N N 431 
TRP HH2  H  N N 432 
TRP HXT  H  N N 433 
TYR N    N  N N 434 
TYR CA   C  N S 435 
TYR C    C  N N 436 
TYR O    O  N N 437 
TYR CB   C  N N 438 
TYR CG   C  Y N 439 
TYR CD1  C  Y N 440 
TYR CD2  C  Y N 441 
TYR CE1  C  Y N 442 
TYR CE2  C  Y N 443 
TYR CZ   C  Y N 444 
TYR OH   O  N N 445 
TYR OXT  O  N N 446 
TYR H    H  N N 447 
TYR H2   H  N N 448 
TYR HA   H  N N 449 
TYR HB2  H  N N 450 
TYR HB3  H  N N 451 
TYR HD1  H  N N 452 
TYR HD2  H  N N 453 
TYR HE1  H  N N 454 
TYR HE2  H  N N 455 
TYR HH   H  N N 456 
TYR HXT  H  N N 457 
VAL N    N  N N 458 
VAL CA   C  N S 459 
VAL C    C  N N 460 
VAL O    O  N N 461 
VAL CB   C  N N 462 
VAL CG1  C  N N 463 
VAL CG2  C  N N 464 
VAL OXT  O  N N 465 
VAL H    H  N N 466 
VAL H2   H  N N 467 
VAL HA   H  N N 468 
VAL HB   H  N N 469 
VAL HG11 H  N N 470 
VAL HG12 H  N N 471 
VAL HG13 H  N N 472 
VAL HG21 H  N N 473 
VAL HG22 H  N N 474 
VAL HG23 H  N N 475 
VAL HXT  H  N N 476 
ZN  ZN   ZN N N 477 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
DMS S   O    doub N N 83  
DMS S   C1   sing N N 84  
DMS S   C2   sing N N 85  
DMS C1  H11  sing N N 86  
DMS C1  H12  sing N N 87  
DMS C1  H13  sing N N 88  
DMS C2  H21  sing N N 89  
DMS C2  H22  sing N N 90  
DMS C2  H23  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
HIS N   CA   sing N N 138 
HIS N   H    sing N N 139 
HIS N   H2   sing N N 140 
HIS CA  C    sing N N 141 
HIS CA  CB   sing N N 142 
HIS CA  HA   sing N N 143 
HIS C   O    doub N N 144 
HIS C   OXT  sing N N 145 
HIS CB  CG   sing N N 146 
HIS CB  HB2  sing N N 147 
HIS CB  HB3  sing N N 148 
HIS CG  ND1  sing Y N 149 
HIS CG  CD2  doub Y N 150 
HIS ND1 CE1  doub Y N 151 
HIS ND1 HD1  sing N N 152 
HIS CD2 NE2  sing Y N 153 
HIS CD2 HD2  sing N N 154 
HIS CE1 NE2  sing Y N 155 
HIS CE1 HE1  sing N N 156 
HIS NE2 HE2  sing N N 157 
HIS OXT HXT  sing N N 158 
HOH O   H1   sing N N 159 
HOH O   H2   sing N N 160 
ILE N   CA   sing N N 161 
ILE N   H    sing N N 162 
ILE N   H2   sing N N 163 
ILE CA  C    sing N N 164 
ILE CA  CB   sing N N 165 
ILE CA  HA   sing N N 166 
ILE C   O    doub N N 167 
ILE C   OXT  sing N N 168 
ILE CB  CG1  sing N N 169 
ILE CB  CG2  sing N N 170 
ILE CB  HB   sing N N 171 
ILE CG1 CD1  sing N N 172 
ILE CG1 HG12 sing N N 173 
ILE CG1 HG13 sing N N 174 
ILE CG2 HG21 sing N N 175 
ILE CG2 HG22 sing N N 176 
ILE CG2 HG23 sing N N 177 
ILE CD1 HD11 sing N N 178 
ILE CD1 HD12 sing N N 179 
ILE CD1 HD13 sing N N 180 
ILE OXT HXT  sing N N 181 
K07 N2  C7   doub Y N 182 
K07 N2  C8   sing Y N 183 
K07 C7  N1   sing Y N 184 
K07 C8  C9   doub Y N 185 
K07 N1  C6   doub Y N 186 
K07 C9  C6   sing Y N 187 
K07 C9  CL   sing N N 188 
K07 C6  N    sing N N 189 
K07 N   C1   sing N N 190 
K07 N   C    sing N N 191 
K07 C1  C2   sing N N 192 
K07 C2  C3   sing N N 193 
K07 C2  C5   sing N N 194 
K07 C3  C4   sing N N 195 
K07 C5  O    sing N N 196 
K07 C4  O    sing N N 197 
K07 C4  H1   sing N N 198 
K07 C4  H2   sing N N 199 
K07 C5  H3   sing N N 200 
K07 C5  H4   sing N N 201 
K07 C7  H5   sing N N 202 
K07 C8  H6   sing N N 203 
K07 C   H7   sing N N 204 
K07 C   H8   sing N N 205 
K07 C   H9   sing N N 206 
K07 C1  H10  sing N N 207 
K07 C1  H11  sing N N 208 
K07 C2  H12  sing N N 209 
K07 C3  H13  sing N N 210 
K07 C3  H14  sing N N 211 
LEU N   CA   sing N N 212 
LEU N   H    sing N N 213 
LEU N   H2   sing N N 214 
LEU CA  C    sing N N 215 
LEU CA  CB   sing N N 216 
LEU CA  HA   sing N N 217 
LEU C   O    doub N N 218 
LEU C   OXT  sing N N 219 
LEU CB  CG   sing N N 220 
LEU CB  HB2  sing N N 221 
LEU CB  HB3  sing N N 222 
LEU CG  CD1  sing N N 223 
LEU CG  CD2  sing N N 224 
LEU CG  HG   sing N N 225 
LEU CD1 HD11 sing N N 226 
LEU CD1 HD12 sing N N 227 
LEU CD1 HD13 sing N N 228 
LEU CD2 HD21 sing N N 229 
LEU CD2 HD22 sing N N 230 
LEU CD2 HD23 sing N N 231 
LEU OXT HXT  sing N N 232 
LYS N   CA   sing N N 233 
LYS N   H    sing N N 234 
LYS N   H2   sing N N 235 
LYS CA  C    sing N N 236 
LYS CA  CB   sing N N 237 
LYS CA  HA   sing N N 238 
LYS C   O    doub N N 239 
LYS C   OXT  sing N N 240 
LYS CB  CG   sing N N 241 
LYS CB  HB2  sing N N 242 
LYS CB  HB3  sing N N 243 
LYS CG  CD   sing N N 244 
LYS CG  HG2  sing N N 245 
LYS CG  HG3  sing N N 246 
LYS CD  CE   sing N N 247 
LYS CD  HD2  sing N N 248 
LYS CD  HD3  sing N N 249 
LYS CE  NZ   sing N N 250 
LYS CE  HE2  sing N N 251 
LYS CE  HE3  sing N N 252 
LYS NZ  HZ1  sing N N 253 
LYS NZ  HZ2  sing N N 254 
LYS NZ  HZ3  sing N N 255 
LYS OXT HXT  sing N N 256 
MES O1  C2   sing N N 257 
MES O1  C6   sing N N 258 
MES C2  C3   sing N N 259 
MES C2  H21  sing N N 260 
MES C2  H22  sing N N 261 
MES C3  N4   sing N N 262 
MES C3  H31  sing N N 263 
MES C3  H32  sing N N 264 
MES N4  C5   sing N N 265 
MES N4  C7   sing N N 266 
MES N4  HN4  sing N N 267 
MES C5  C6   sing N N 268 
MES C5  H51  sing N N 269 
MES C5  H52  sing N N 270 
MES C6  H61  sing N N 271 
MES C6  H62  sing N N 272 
MES C7  C8   sing N N 273 
MES C7  H71  sing N N 274 
MES C7  H72  sing N N 275 
MES C8  S    sing N N 276 
MES C8  H81  sing N N 277 
MES C8  H82  sing N N 278 
MES S   O1S  doub N N 279 
MES S   O2S  doub N N 280 
MES S   O3S  sing N N 281 
MET N   CA   sing N N 282 
MET N   H    sing N N 283 
MET N   H2   sing N N 284 
MET CA  C    sing N N 285 
MET CA  CB   sing N N 286 
MET CA  HA   sing N N 287 
MET C   O    doub N N 288 
MET C   OXT  sing N N 289 
MET CB  CG   sing N N 290 
MET CB  HB2  sing N N 291 
MET CB  HB3  sing N N 292 
MET CG  SD   sing N N 293 
MET CG  HG2  sing N N 294 
MET CG  HG3  sing N N 295 
MET SD  CE   sing N N 296 
MET CE  HE1  sing N N 297 
MET CE  HE2  sing N N 298 
MET CE  HE3  sing N N 299 
MET OXT HXT  sing N N 300 
PEG C1  O1   sing N N 301 
PEG C1  C2   sing N N 302 
PEG C1  H11  sing N N 303 
PEG C1  H12  sing N N 304 
PEG O1  HO1  sing N N 305 
PEG C2  O2   sing N N 306 
PEG C2  H21  sing N N 307 
PEG C2  H22  sing N N 308 
PEG O2  C3   sing N N 309 
PEG C3  C4   sing N N 310 
PEG C3  H31  sing N N 311 
PEG C3  H32  sing N N 312 
PEG C4  O4   sing N N 313 
PEG C4  H41  sing N N 314 
PEG C4  H42  sing N N 315 
PEG O4  HO4  sing N N 316 
PHE N   CA   sing N N 317 
PHE N   H    sing N N 318 
PHE N   H2   sing N N 319 
PHE CA  C    sing N N 320 
PHE CA  CB   sing N N 321 
PHE CA  HA   sing N N 322 
PHE C   O    doub N N 323 
PHE C   OXT  sing N N 324 
PHE CB  CG   sing N N 325 
PHE CB  HB2  sing N N 326 
PHE CB  HB3  sing N N 327 
PHE CG  CD1  doub Y N 328 
PHE CG  CD2  sing Y N 329 
PHE CD1 CE1  sing Y N 330 
PHE CD1 HD1  sing N N 331 
PHE CD2 CE2  doub Y N 332 
PHE CD2 HD2  sing N N 333 
PHE CE1 CZ   doub Y N 334 
PHE CE1 HE1  sing N N 335 
PHE CE2 CZ   sing Y N 336 
PHE CE2 HE2  sing N N 337 
PHE CZ  HZ   sing N N 338 
PHE OXT HXT  sing N N 339 
PO4 P   O1   doub N N 340 
PO4 P   O2   sing N N 341 
PO4 P   O3   sing N N 342 
PO4 P   O4   sing N N 343 
PRO N   CA   sing N N 344 
PRO N   CD   sing N N 345 
PRO N   H    sing N N 346 
PRO CA  C    sing N N 347 
PRO CA  CB   sing N N 348 
PRO CA  HA   sing N N 349 
PRO C   O    doub N N 350 
PRO C   OXT  sing N N 351 
PRO CB  CG   sing N N 352 
PRO CB  HB2  sing N N 353 
PRO CB  HB3  sing N N 354 
PRO CG  CD   sing N N 355 
PRO CG  HG2  sing N N 356 
PRO CG  HG3  sing N N 357 
PRO CD  HD2  sing N N 358 
PRO CD  HD3  sing N N 359 
PRO OXT HXT  sing N N 360 
SER N   CA   sing N N 361 
SER N   H    sing N N 362 
SER N   H2   sing N N 363 
SER CA  C    sing N N 364 
SER CA  CB   sing N N 365 
SER CA  HA   sing N N 366 
SER C   O    doub N N 367 
SER C   OXT  sing N N 368 
SER CB  OG   sing N N 369 
SER CB  HB2  sing N N 370 
SER CB  HB3  sing N N 371 
SER OG  HG   sing N N 372 
SER OXT HXT  sing N N 373 
THR N   CA   sing N N 374 
THR N   H    sing N N 375 
THR N   H2   sing N N 376 
THR CA  C    sing N N 377 
THR CA  CB   sing N N 378 
THR CA  HA   sing N N 379 
THR C   O    doub N N 380 
THR C   OXT  sing N N 381 
THR CB  OG1  sing N N 382 
THR CB  CG2  sing N N 383 
THR CB  HB   sing N N 384 
THR OG1 HG1  sing N N 385 
THR CG2 HG21 sing N N 386 
THR CG2 HG22 sing N N 387 
THR CG2 HG23 sing N N 388 
THR OXT HXT  sing N N 389 
TRP N   CA   sing N N 390 
TRP N   H    sing N N 391 
TRP N   H2   sing N N 392 
TRP CA  C    sing N N 393 
TRP CA  CB   sing N N 394 
TRP CA  HA   sing N N 395 
TRP C   O    doub N N 396 
TRP C   OXT  sing N N 397 
TRP CB  CG   sing N N 398 
TRP CB  HB2  sing N N 399 
TRP CB  HB3  sing N N 400 
TRP CG  CD1  doub Y N 401 
TRP CG  CD2  sing Y N 402 
TRP CD1 NE1  sing Y N 403 
TRP CD1 HD1  sing N N 404 
TRP CD2 CE2  doub Y N 405 
TRP CD2 CE3  sing Y N 406 
TRP NE1 CE2  sing Y N 407 
TRP NE1 HE1  sing N N 408 
TRP CE2 CZ2  sing Y N 409 
TRP CE3 CZ3  doub Y N 410 
TRP CE3 HE3  sing N N 411 
TRP CZ2 CH2  doub Y N 412 
TRP CZ2 HZ2  sing N N 413 
TRP CZ3 CH2  sing Y N 414 
TRP CZ3 HZ3  sing N N 415 
TRP CH2 HH2  sing N N 416 
TRP OXT HXT  sing N N 417 
TYR N   CA   sing N N 418 
TYR N   H    sing N N 419 
TYR N   H2   sing N N 420 
TYR CA  C    sing N N 421 
TYR CA  CB   sing N N 422 
TYR CA  HA   sing N N 423 
TYR C   O    doub N N 424 
TYR C   OXT  sing N N 425 
TYR CB  CG   sing N N 426 
TYR CB  HB2  sing N N 427 
TYR CB  HB3  sing N N 428 
TYR CG  CD1  doub Y N 429 
TYR CG  CD2  sing Y N 430 
TYR CD1 CE1  sing Y N 431 
TYR CD1 HD1  sing N N 432 
TYR CD2 CE2  doub Y N 433 
TYR CD2 HD2  sing N N 434 
TYR CE1 CZ   doub Y N 435 
TYR CE1 HE1  sing N N 436 
TYR CE2 CZ   sing Y N 437 
TYR CE2 HE2  sing N N 438 
TYR CZ  OH   sing N N 439 
TYR OH  HH   sing N N 440 
TYR OXT HXT  sing N N 441 
VAL N   CA   sing N N 442 
VAL N   H    sing N N 443 
VAL N   H2   sing N N 444 
VAL CA  C    sing N N 445 
VAL CA  CB   sing N N 446 
VAL CA  HA   sing N N 447 
VAL C   O    doub N N 448 
VAL C   OXT  sing N N 449 
VAL CB  CG1  sing N N 450 
VAL CB  CG2  sing N N 451 
VAL CB  HB   sing N N 452 
VAL CG1 HG11 sing N N 453 
VAL CG1 HG12 sing N N 454 
VAL CG1 HG13 sing N N 455 
VAL CG2 HG21 sing N N 456 
VAL CG2 HG22 sing N N 457 
VAL CG2 HG23 sing N N 458 
VAL OXT HXT  sing N N 459 
# 
_pdbx_audit_support.ordinal                1 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)' 
_pdbx_audit_support.grant_number           U19AI171292 
_pdbx_audit_support.country                'United States' 
# 
_pdbx_deposit_group.group_id            G_1002341 
_pdbx_deposit_group.group_description   
'Crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_title         
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_type          'changed state' 
# 
_atom_sites.entry_id                    7I2O 
_atom_sites.fract_transf_matrix[1][1]   0.012129 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.008601 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006807 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
# 
loop_
_atom_type.symbol 
C  
CL 
N  
O  
P  
S  
ZN 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ASN A 1 10  ? -14.112 -5.709  -12.433 0.50 113.67 ? 273  ASN A N   1 
ATOM   2    C  CA  . ASN A 1 10  ? -13.812 -6.749  -11.407 0.50 111.16 ? 273  ASN A CA  1 
ATOM   3    C  C   . ASN A 1 10  ? -14.900 -6.717  -10.325 0.50 108.68 ? 273  ASN A C   1 
ATOM   4    O  O   . ASN A 1 10  ? -15.939 -7.382  -10.518 0.50 109.36 ? 273  ASN A O   1 
ATOM   5    C  CB  . ASN A 1 10  ? -12.417 -6.565  -10.801 0.50 112.24 ? 273  ASN A CB  1 
ATOM   6    C  CG  . ASN A 1 10  ? -12.133 -7.512  -9.652  0.50 110.95 ? 273  ASN A CG  1 
ATOM   7    O  OD1 . ASN A 1 10  ? -12.773 -8.553  -9.526  0.50 112.17 ? 273  ASN A OD1 1 
ATOM   8    N  ND2 . ASN A 1 10  ? -11.178 -7.161  -8.805  0.50 105.67 ? 273  ASN A ND2 1 
ATOM   9    N  N   . LEU A 1 11  ? -14.668 -5.959  -9.246  0.50 103.30 ? 274  LEU A N   1 
ATOM   10   C  CA  . LEU A 1 11  ? -15.517 -5.941  -8.023  0.50 96.14  ? 274  LEU A CA  1 
ATOM   11   C  C   . LEU A 1 11  ? -16.924 -5.436  -8.360  0.50 88.83  ? 274  LEU A C   1 
ATOM   12   O  O   . LEU A 1 11  ? -17.865 -5.814  -7.641  0.50 81.89  ? 274  LEU A O   1 
ATOM   13   C  CB  . LEU A 1 11  ? -14.849 -5.077  -6.951  0.50 99.26  ? 274  LEU A CB  1 
ATOM   14   C  CG  . LEU A 1 11  ? -14.170 -5.862  -5.829  0.50 103.30 ? 274  LEU A CG  1 
ATOM   15   C  CD1 . LEU A 1 11  ? -13.378 -4.939  -4.915  0.50 104.37 ? 274  LEU A CD1 1 
ATOM   16   C  CD2 . LEU A 1 11  ? -15.194 -6.657  -5.032  0.50 101.60 ? 274  LEU A CD2 1 
ATOM   17   N  N   . ASP A 1 12  ? -17.063 -4.625  -9.411  0.50 81.54  ? 275  ASP A N   1 
ATOM   18   C  CA  . ASP A 1 12  ? -18.382 -4.165  -9.924  0.50 84.89  ? 275  ASP A CA  1 
ATOM   19   C  C   . ASP A 1 12  ? -19.172 -5.387  -10.407 0.50 81.73  ? 275  ASP A C   1 
ATOM   20   O  O   . ASP A 1 12  ? -20.392 -5.448  -10.153 0.50 84.52  ? 275  ASP A O   1 
ATOM   21   C  CB  . ASP A 1 12  ? -18.213 -3.134  -11.043 0.50 87.81  ? 275  ASP A CB  1 
ATOM   22   C  CG  . ASP A 1 12  ? -17.274 -3.583  -12.149 0.50 88.82  ? 275  ASP A CG  1 
ATOM   23   O  OD1 . ASP A 1 12  ? -16.321 -4.332  -11.842 0.50 86.76  ? 275  ASP A OD1 1 
ATOM   24   O  OD2 . ASP A 1 12  ? -17.507 -3.187  -13.309 0.50 85.42  ? 275  ASP A OD2 1 
ATOM   25   N  N   . ILE A 1 13  ? -18.477 -6.329  -11.055 0.50 77.60  ? 276  ILE A N   1 
ATOM   26   C  CA  . ILE A 1 13  ? -19.035 -7.555  -11.704 0.50 71.61  ? 276  ILE A CA  1 
ATOM   27   C  C   . ILE A 1 13  ? -19.349 -8.619  -10.643 0.50 69.72  ? 276  ILE A C   1 
ATOM   28   O  O   . ILE A 1 13  ? -20.408 -9.266  -10.762 0.50 64.57  ? 276  ILE A O   1 
ATOM   29   C  CB  . ILE A 1 13  ? -18.056 -8.074  -12.774 0.50 69.59  ? 276  ILE A CB  1 
ATOM   30   C  CG1 . ILE A 1 13  ? -17.973 -7.109  -13.961 0.50 66.54  ? 276  ILE A CG1 1 
ATOM   31   C  CG2 . ILE A 1 13  ? -18.423 -9.487  -13.205 0.50 68.79  ? 276  ILE A CG2 1 
ATOM   32   C  CD1 . ILE A 1 13  ? -17.002 -7.527  -15.033 0.50 66.16  ? 276  ILE A CD1 1 
ATOM   33   N  N   . ILE A 1 14  ? -18.475 -8.782  -9.642  1.00 70.81  ? 277  ILE A N   1 
ATOM   34   C  CA  . ILE A 1 14  ? -18.632 -9.834  -8.584  1.00 76.72  ? 277  ILE A CA  1 
ATOM   35   C  C   . ILE A 1 14  ? -19.275 -9.286  -7.294  1.00 77.80  ? 277  ILE A C   1 
ATOM   36   O  O   . ILE A 1 14  ? -19.877 -10.106 -6.576  1.00 79.74  ? 277  ILE A O   1 
ATOM   37   C  CB  . ILE A 1 14  ? -17.280 -10.535 -8.330  1.00 80.86  ? 277  ILE A CB  1 
ATOM   38   C  CG1 . ILE A 1 14  ? -16.190 -9.553  -7.893  1.00 79.84  ? 277  ILE A CG1 1 
ATOM   39   C  CG2 . ILE A 1 14  ? -16.867 -11.321 -9.569  1.00 81.06  ? 277  ILE A CG2 1 
ATOM   40   C  CD1 . ILE A 1 14  ? -14.887 -10.197 -7.496  1.00 81.72  ? 277  ILE A CD1 1 
ATOM   41   N  N   . GLY A 1 15  ? -19.196 -7.974  -7.016  1.00 92.82  ? 278  GLY A N   1 
ATOM   42   C  CA  . GLY A 1 15  ? -19.643 -7.331  -5.751  1.00 80.79  ? 278  GLY A CA  1 
ATOM   43   C  C   . GLY A 1 15  ? -21.063 -7.694  -5.344  1.00 74.49  ? 278  GLY A C   1 
ATOM   44   O  O   . GLY A 1 15  ? -21.278 -8.115  -4.199  1.00 83.40  ? 278  GLY A O   1 
ATOM   45   N  N   . LYS A 1 16  ? -22.012 -7.535  -6.270  0.50 74.14  ? 279  LYS A N   1 
ATOM   46   C  CA  . LYS A 1 16  ? -23.461 -7.794  -6.051  0.50 73.92  ? 279  LYS A CA  1 
ATOM   47   C  C   . LYS A 1 16  ? -23.631 -9.206  -5.482  0.50 73.10  ? 279  LYS A C   1 
ATOM   48   O  O   . LYS A 1 16  ? -24.335 -9.358  -4.464  0.50 67.36  ? 279  LYS A O   1 
ATOM   49   C  CB  . LYS A 1 16  ? -24.218 -7.611  -7.370  0.50 76.28  ? 279  LYS A CB  1 
ATOM   50   C  CG  . LYS A 1 16  ? -25.736 -7.672  -7.280  0.50 78.62  ? 279  LYS A CG  1 
ATOM   51   C  CD  . LYS A 1 16  ? -26.415 -7.325  -8.590  0.50 81.55  ? 279  LYS A CD  1 
ATOM   52   C  CE  . LYS A 1 16  ? -27.926 -7.357  -8.517  0.50 84.24  ? 279  LYS A CE  1 
ATOM   53   N  NZ  . LYS A 1 16  ? -28.455 -6.257  -7.678  0.50 87.47  ? 279  LYS A NZ  1 
ATOM   54   N  N   . ARG A 1 17  ? -22.988 -10.193 -6.111  0.50 74.78  ? 280  ARG A N   1 
ATOM   55   C  CA  . ARG A 1 17  ? -22.993 -11.608 -5.659  0.50 75.87  ? 280  ARG A CA  1 
ATOM   56   C  C   . ARG A 1 17  ? -22.404 -11.674 -4.247  0.50 77.39  ? 280  ARG A C   1 
ATOM   57   O  O   . ARG A 1 17  ? -23.012 -12.339 -3.385  0.50 77.61  ? 280  ARG A O   1 
ATOM   58   C  CB  . ARG A 1 17  ? -22.198 -12.493 -6.625  0.50 74.68  ? 280  ARG A CB  1 
ATOM   59   C  CG  . ARG A 1 17  ? -23.030 -13.091 -7.749  0.50 72.30  ? 280  ARG A CG  1 
ATOM   60   C  CD  . ARG A 1 17  ? -22.187 -13.843 -8.758  0.50 65.47  ? 280  ARG A CD  1 
ATOM   61   N  NE  . ARG A 1 17  ? -21.529 -12.934 -9.682  0.50 64.69  ? 280  ARG A NE  1 
ATOM   62   C  CZ  . ARG A 1 17  ? -20.695 -13.310 -10.642 0.50 63.83  ? 280  ARG A CZ  1 
ATOM   63   N  NH1 . ARG A 1 17  ? -20.404 -14.589 -10.804 0.50 64.41  ? 280  ARG A NH1 1 
ATOM   64   N  NH2 . ARG A 1 17  ? -20.151 -12.406 -11.436 0.50 62.86  ? 280  ARG A NH2 1 
ATOM   65   N  N   . ILE A 1 18  ? -21.270 -10.998 -4.036  0.50 81.90  ? 281  ILE A N   1 
ATOM   66   C  CA  . ILE A 1 18  ? -20.527 -10.962 -2.740  0.50 84.94  ? 281  ILE A CA  1 
ATOM   67   C  C   . ILE A 1 18  ? -21.399 -10.254 -1.696  0.50 88.15  ? 281  ILE A C   1 
ATOM   68   O  O   . ILE A 1 18  ? -21.648 -10.861 -0.631  0.50 89.20  ? 281  ILE A O   1 
ATOM   69   C  CB  . ILE A 1 18  ? -19.147 -10.295 -2.918  0.50 85.47  ? 281  ILE A CB  1 
ATOM   70   C  CG1 . ILE A 1 18  ? -18.236 -11.123 -3.828  0.50 85.10  ? 281  ILE A CG1 1 
ATOM   71   C  CG2 . ILE A 1 18  ? -18.491 -10.029 -1.572  0.50 86.35  ? 281  ILE A CG2 1 
ATOM   72   C  CD1 . ILE A 1 18  ? -16.915 -10.462 -4.137  0.50 85.88  ? 281  ILE A CD1 1 
ATOM   73   N  N   . GLU A 1 19  ? -21.870 -9.040  -2.010  1.00 91.23  ? 282  GLU A N   1 
ATOM   74   C  CA  . GLU A 1 19  ? -22.734 -8.219  -1.104  1.00 90.33  ? 282  GLU A CA  1 
ATOM   75   C  C   . GLU A 1 19  ? -23.962 -9.003  -0.630  1.00 87.85  ? 282  GLU A C   1 
ATOM   76   O  O   . GLU A 1 19  ? -24.267 -8.965  0.573   1.00 86.70  ? 282  GLU A O   1 
ATOM   77   C  CB  . GLU A 1 19  ? -23.204 -6.937  -1.788  1.00 94.10  ? 282  GLU A CB  1 
ATOM   78   C  CG  . GLU A 1 19  ? -22.099 -5.910  -1.952  1.00 105.87 ? 282  GLU A CG  1 
ATOM   79   C  CD  . GLU A 1 19  ? -22.309 -4.924  -3.091  1.00 118.71 ? 282  GLU A CD  1 
ATOM   80   O  OE1 . GLU A 1 19  ? -23.478 -4.573  -3.369  1.00 134.75 ? 282  GLU A OE1 1 
ATOM   81   O  OE2 . GLU A 1 19  ? -21.300 -4.518  -3.712  1.00 131.33 ? 282  GLU A OE2 1 
ATOM   82   N  N   . LYS A 1 20  ? -24.635 -9.701  -1.552  0.50 88.60  ? 283  LYS A N   1 
ATOM   83   C  CA  . LYS A 1 20  ? -25.887 -10.457 -1.278  0.50 88.47  ? 283  LYS A CA  1 
ATOM   84   C  C   . LYS A 1 20  ? -25.617 -11.559 -0.250  0.50 89.58  ? 283  LYS A C   1 
ATOM   85   O  O   . LYS A 1 20  ? -26.460 -11.734 0.651   0.50 92.67  ? 283  LYS A O   1 
ATOM   86   C  CB  . LYS A 1 20  ? -26.457 -11.086 -2.551  0.50 87.71  ? 283  LYS A CB  1 
ATOM   87   C  CG  . LYS A 1 20  ? -27.590 -12.074 -2.309  0.50 87.84  ? 283  LYS A CG  1 
ATOM   88   C  CD  . LYS A 1 20  ? -28.336 -12.464 -3.566  0.50 90.68  ? 283  LYS A CD  1 
ATOM   89   C  CE  . LYS A 1 20  ? -29.585 -13.278 -3.298  0.50 90.03  ? 283  LYS A CE  1 
ATOM   90   N  NZ  . LYS A 1 20  ? -29.277 -14.552 -2.605  0.50 91.99  ? 283  LYS A NZ  1 
ATOM   91   N  N   . ILE A 1 21  ? -24.498 -12.276 -0.393  0.50 89.80  ? 284  ILE A N   1 
ATOM   92   C  CA  . ILE A 1 21  ? -24.129 -13.432 0.479   0.50 93.05  ? 284  ILE A CA  1 
ATOM   93   C  C   . ILE A 1 21  ? -23.899 -12.920 1.907   0.50 91.99  ? 284  ILE A C   1 
ATOM   94   O  O   . ILE A 1 21  ? -24.464 -13.522 2.848   0.50 86.16  ? 284  ILE A O   1 
ATOM   95   C  CB  . ILE A 1 21  ? -22.901 -14.181 -0.075  0.50 96.10  ? 284  ILE A CB  1 
ATOM   96   C  CG1 . ILE A 1 21  ? -23.158 -14.723 -1.484  0.50 96.00  ? 284  ILE A CG1 1 
ATOM   97   C  CG2 . ILE A 1 21  ? -22.464 -15.285 0.877   0.50 94.94  ? 284  ILE A CG2 1 
ATOM   98   C  CD1 . ILE A 1 21  ? -21.999 -15.498 -2.063  0.50 96.08  ? 284  ILE A CD1 1 
ATOM   99   N  N   . LYS A 1 22  ? -23.108 -11.853 2.064   0.50 89.64  ? 285  LYS A N   1 
ATOM   100  C  CA  . LYS A 1 22  ? -22.837 -11.228 3.386   0.50 89.92  ? 285  LYS A CA  1 
ATOM   101  C  C   . LYS A 1 22  ? -24.173 -11.044 4.113   0.50 89.51  ? 285  LYS A C   1 
ATOM   102  O  O   . LYS A 1 22  ? -24.382 -11.704 5.149   0.50 83.52  ? 285  LYS A O   1 
ATOM   103  C  CB  . LYS A 1 22  ? -22.104 -9.892  3.232   0.50 91.29  ? 285  LYS A CB  1 
ATOM   104  C  CG  . LYS A 1 22  ? -21.872 -9.147  4.541   0.50 95.67  ? 285  LYS A CG  1 
ATOM   105  C  CD  . LYS A 1 22  ? -21.103 -7.848  4.395   0.50 98.86  ? 285  LYS A CD  1 
ATOM   106  C  CE  . LYS A 1 22  ? -21.005 -7.074  5.693   0.50 98.05  ? 285  LYS A CE  1 
ATOM   107  N  NZ  . LYS A 1 22  ? -20.276 -5.795  5.518   0.50 98.56  ? 285  LYS A NZ  1 
ATOM   108  N  N   . GLN A 1 23  ? -25.050 -10.202 3.559   0.50 93.13  ? 286  GLN A N   1 
ATOM   109  C  CA  . GLN A 1 23  ? -26.385 -9.868  4.125   0.50 94.61  ? 286  GLN A CA  1 
ATOM   110  C  C   . GLN A 1 23  ? -27.046 -11.127 4.701   0.50 94.36  ? 286  GLN A C   1 
ATOM   111  O  O   . GLN A 1 23  ? -27.540 -11.053 5.840   0.50 99.89  ? 286  GLN A O   1 
ATOM   112  C  CB  . GLN A 1 23  ? -27.262 -9.222  3.052   0.50 95.11  ? 286  GLN A CB  1 
ATOM   113  C  CG  . GLN A 1 23  ? -26.713 -7.893  2.555   0.50 98.82  ? 286  GLN A CG  1 
ATOM   114  C  CD  . GLN A 1 23  ? -27.391 -7.425  1.292   0.50 102.30 ? 286  GLN A CD  1 
ATOM   115  O  OE1 . GLN A 1 23  ? -28.323 -8.053  0.793   0.50 104.71 ? 286  GLN A OE1 1 
ATOM   116  N  NE2 . GLN A 1 23  ? -26.921 -6.308  0.761   0.50 104.33 ? 286  GLN A NE2 1 
ATOM   117  N  N   . GLU A 1 24  ? -27.019 -12.241 3.970   0.50 94.28  ? 287  GLU A N   1 
ATOM   118  C  CA  . GLU A 1 24  ? -27.711 -13.475 4.432   0.50 95.62  ? 287  GLU A CA  1 
ATOM   119  C  C   . GLU A 1 24  ? -26.914 -14.122 5.568   0.50 99.24  ? 287  GLU A C   1 
ATOM   120  O  O   . GLU A 1 24  ? -27.394 -15.126 6.128   0.50 98.06  ? 287  GLU A O   1 
ATOM   121  C  CB  . GLU A 1 24  ? -27.894 -14.432 3.255   0.50 95.23  ? 287  GLU A CB  1 
ATOM   122  C  CG  . GLU A 1 24  ? -28.774 -13.854 2.165   0.50 96.43  ? 287  GLU A CG  1 
ATOM   123  C  CD  . GLU A 1 24  ? -28.309 -14.125 0.746   0.50 94.95  ? 287  GLU A CD  1 
ATOM   124  O  OE1 . GLU A 1 24  ? -29.026 -13.722 -0.188  0.50 87.96  ? 287  GLU A OE1 1 
ATOM   125  O  OE2 . GLU A 1 24  ? -27.232 -14.729 0.579   0.50 94.45  ? 287  GLU A OE2 1 
ATOM   126  N  N   . HIS A 1 25  ? -25.743 -13.571 5.887   0.50 105.60 ? 288  HIS A N   1 
ATOM   127  C  CA  . HIS A 1 25  ? -24.888 -14.123 6.972   0.50 108.92 ? 288  HIS A CA  1 
ATOM   128  C  C   . HIS A 1 25  ? -24.256 -12.961 7.744   0.50 113.06 ? 288  HIS A C   1 
ATOM   129  O  O   . HIS A 1 25  ? -23.117 -13.119 8.222   0.50 112.68 ? 288  HIS A O   1 
ATOM   130  C  CB  . HIS A 1 25  ? -23.844 -15.079 6.381   0.50 105.09 ? 288  HIS A CB  1 
ATOM   131  C  CG  . HIS A 1 25  ? -24.424 -16.120 5.485   0.50 100.56 ? 288  HIS A CG  1 
ATOM   132  N  ND1 . HIS A 1 25  ? -25.150 -17.189 5.971   0.50 100.51 ? 288  HIS A ND1 1 
ATOM   133  C  CD2 . HIS A 1 25  ? -24.389 -16.263 4.143   0.50 98.24  ? 288  HIS A CD2 1 
ATOM   134  C  CE1 . HIS A 1 25  ? -25.538 -17.946 4.965   0.50 98.51  ? 288  HIS A CE1 1 
ATOM   135  N  NE2 . HIS A 1 25  ? -25.084 -17.399 3.834   0.50 97.52  ? 288  HIS A NE2 1 
ATOM   136  N  N   . GLU A 1 26  ? -24.973 -11.840 7.856   0.50 118.31 ? 289  GLU A N   1 
ATOM   137  C  CA  . GLU A 1 26  ? -24.433 -10.635 8.542   0.50 120.12 ? 289  GLU A CA  1 
ATOM   138  C  C   . GLU A 1 26  ? -24.086 -10.986 9.992   0.50 121.18 ? 289  GLU A C   1 
ATOM   139  O  O   . GLU A 1 26  ? -23.171 -10.352 10.549  0.50 115.96 ? 289  GLU A O   1 
ATOM   140  C  CB  . GLU A 1 26  ? -25.468 -9.510  8.496   0.50 118.61 ? 289  GLU A CB  1 
ATOM   141  C  CG  . GLU A 1 26  ? -24.908 -8.153  8.877   0.50 119.11 ? 289  GLU A CG  1 
ATOM   142  C  CD  . GLU A 1 26  ? -24.100 -7.475  7.785   0.50 118.68 ? 289  GLU A CD  1 
ATOM   143  O  OE1 . GLU A 1 26  ? -23.357 -6.528  8.105   0.50 119.26 ? 289  GLU A OE1 1 
ATOM   144  O  OE2 . GLU A 1 26  ? -24.225 -7.889  6.616   0.50 116.29 ? 289  GLU A OE2 1 
ATOM   145  N  N   . THR A 1 27  ? -24.792 -11.958 10.572  0.50 123.95 ? 290  THR A N   1 
ATOM   146  C  CA  . THR A 1 27  ? -24.564 -12.341 11.990  0.50 125.53 ? 290  THR A CA  1 
ATOM   147  C  C   . THR A 1 27  ? -23.222 -13.062 12.153  0.50 121.81 ? 290  THR A C   1 
ATOM   148  O  O   . THR A 1 27  ? -22.652 -12.981 13.259  0.50 125.25 ? 290  THR A O   1 
ATOM   149  C  CB  . THR A 1 27  ? -25.711 -13.219 12.507  0.50 127.41 ? 290  THR A CB  1 
ATOM   150  O  OG1 . THR A 1 27  ? -26.932 -12.504 12.311  0.50 131.87 ? 290  THR A OG1 1 
ATOM   151  C  CG2 . THR A 1 27  ? -25.563 -13.590 13.966  0.50 124.59 ? 290  THR A CG2 1 
ATOM   152  N  N   . SER A 1 28  ? -22.729 -13.736 11.109  0.50 113.20 ? 291  SER A N   1 
ATOM   153  C  CA  . SER A 1 28  ? -21.491 -14.544 11.272  0.50 103.36 ? 291  SER A CA  1 
ATOM   154  C  C   . SER A 1 28  ? -20.432 -14.185 10.225  0.50 97.63  ? 291  SER A C   1 
ATOM   155  O  O   . SER A 1 28  ? -19.777 -15.110 9.732   0.50 96.72  ? 291  SER A O   1 
ATOM   156  C  CB  . SER A 1 28  ? -21.814 -16.012 11.220  0.50 102.47 ? 291  SER A CB  1 
ATOM   157  O  OG  . SER A 1 28  ? -22.783 -16.351 12.200  0.50 103.21 ? 291  SER A OG  1 
ATOM   158  N  N   . TRP A 1 29  ? -20.254 -12.901 9.914   1.00 94.20  ? 292  TRP A N   1 
ATOM   159  C  CA  . TRP A 1 29  ? -19.296 -12.514 8.842   1.00 100.49 ? 292  TRP A CA  1 
ATOM   160  C  C   . TRP A 1 29  ? -17.945 -12.156 9.466   1.00 101.22 ? 292  TRP A C   1 
ATOM   161  O  O   . TRP A 1 29  ? -17.947 -11.580 10.564  1.00 106.84 ? 292  TRP A O   1 
ATOM   162  C  CB  . TRP A 1 29  ? -19.855 -11.374 7.981   1.00 90.53  ? 292  TRP A CB  1 
ATOM   163  C  CG  . TRP A 1 29  ? -19.066 -11.055 6.748   1.00 91.93  ? 292  TRP A CG  1 
ATOM   164  C  CD1 . TRP A 1 29  ? -18.161 -10.046 6.591   1.00 98.92  ? 292  TRP A CD1 1 
ATOM   165  C  CD2 . TRP A 1 29  ? -19.128 -11.733 5.481   1.00 86.16  ? 292  TRP A CD2 1 
ATOM   166  N  NE1 . TRP A 1 29  ? -17.651 -10.054 5.321   1.00 89.93  ? 292  TRP A NE1 1 
ATOM   167  C  CE2 . TRP A 1 29  ? -18.225 -11.079 4.617   1.00 94.19  ? 292  TRP A CE2 1 
ATOM   168  C  CE3 . TRP A 1 29  ? -19.850 -12.828 4.993   1.00 78.02  ? 292  TRP A CE3 1 
ATOM   169  C  CZ2 . TRP A 1 29  ? -18.027 -11.486 3.299   1.00 85.43  ? 292  TRP A CZ2 1 
ATOM   170  C  CZ3 . TRP A 1 29  ? -19.653 -13.229 3.692   1.00 77.66  ? 292  TRP A CZ3 1 
ATOM   171  C  CH2 . TRP A 1 29  ? -18.754 -12.566 2.858   1.00 78.85  ? 292  TRP A CH2 1 
ATOM   172  N  N   . HIS A 1 30  ? -16.843 -12.496 8.792   0.50 101.76 ? 293  HIS A N   1 
ATOM   173  C  CA  . HIS A 1 30  ? -15.489 -12.227 9.346   0.50 104.40 ? 293  HIS A CA  1 
ATOM   174  C  C   . HIS A 1 30  ? -14.429 -12.243 8.241   0.50 106.07 ? 293  HIS A C   1 
ATOM   175  O  O   . HIS A 1 30  ? -14.389 -13.229 7.486   0.50 112.11 ? 293  HIS A O   1 
ATOM   176  C  CB  . HIS A 1 30  ? -15.153 -13.228 10.460  0.50 102.60 ? 293  HIS A CB  1 
ATOM   177  C  CG  . HIS A 1 30  ? -15.601 -14.627 10.208  0.50 99.17  ? 293  HIS A CG  1 
ATOM   178  N  ND1 . HIS A 1 30  ? -16.915 -15.019 10.363  0.50 98.37  ? 293  HIS A ND1 1 
ATOM   179  C  CD2 . HIS A 1 30  ? -14.914 -15.734 9.856   0.50 99.44  ? 293  HIS A CD2 1 
ATOM   180  C  CE1 . HIS A 1 30  ? -17.023 -16.304 10.096  0.50 96.56  ? 293  HIS A CE1 1 
ATOM   181  N  NE2 . HIS A 1 30  ? -15.809 -16.766 9.783   0.50 99.83  ? 293  HIS A NE2 1 
ATOM   182  N  N   . TYR A 1 31  ? -13.602 -11.196 8.162   0.50 106.68 ? 294  TYR A N   1 
ATOM   183  C  CA  . TYR A 1 31  ? -12.493 -11.168 7.170   0.50 111.66 ? 294  TYR A CA  1 
ATOM   184  C  C   . TYR A 1 31  ? -11.216 -11.756 7.782   0.50 111.68 ? 294  TYR A C   1 
ATOM   185  O  O   . TYR A 1 31  ? -10.259 -10.991 8.017   0.50 111.82 ? 294  TYR A O   1 
ATOM   186  C  CB  . TYR A 1 31  ? -12.221 -9.741  6.689   0.50 116.30 ? 294  TYR A CB  1 
ATOM   187  C  CG  . TYR A 1 31  ? -11.119 -9.641  5.665   0.50 126.41 ? 294  TYR A CG  1 
ATOM   188  C  CD1 . TYR A 1 31  ? -9.786  -9.636  6.043   0.50 130.84 ? 294  TYR A CD1 1 
ATOM   189  C  CD2 . TYR A 1 31  ? -11.406 -9.569  4.311   0.50 130.98 ? 294  TYR A CD2 1 
ATOM   190  C  CE1 . TYR A 1 31  ? -8.768  -9.554  5.107   0.50 131.74 ? 294  TYR A CE1 1 
ATOM   191  C  CE2 . TYR A 1 31  ? -10.402 -9.486  3.362   0.50 130.68 ? 294  TYR A CE2 1 
ATOM   192  C  CZ  . TYR A 1 31  ? -9.078  -9.478  3.761   0.50 131.50 ? 294  TYR A CZ  1 
ATOM   193  O  OH  . TYR A 1 31  ? -8.082  -9.396  2.832   0.50 134.92 ? 294  TYR A OH  1 
ATOM   194  N  N   . ASP A 1 32  ? -11.203 -13.075 8.001   1.00 110.68 ? 295  ASP A N   1 
ATOM   195  C  CA  . ASP A 1 32  ? -10.055 -13.816 8.608   1.00 115.97 ? 295  ASP A CA  1 
ATOM   196  C  C   . ASP A 1 32  ? -8.731  -13.508 7.864   1.00 121.13 ? 295  ASP A C   1 
ATOM   197  O  O   . ASP A 1 32  ? -8.742  -13.387 6.614   1.00 122.34 ? 295  ASP A O   1 
ATOM   198  C  CB  . ASP A 1 32  ? -10.403 -15.309 8.713   1.00 104.69 ? 295  ASP A CB  1 
ATOM   199  C  CG  . ASP A 1 32  ? -9.203  -16.235 8.758   1.00 102.54 ? 295  ASP A CG  1 
ATOM   200  O  OD1 . ASP A 1 32  ? -8.171  -15.856 9.367   1.00 86.50  ? 295  ASP A OD1 1 
ATOM   201  O  OD2 . ASP A 1 32  ? -9.298  -17.313 8.155   1.00 107.65 ? 295  ASP A OD2 1 
ATOM   202  N  N   . GLN A 1 33  ? -7.639  -13.350 8.631   1.00 124.85 ? 296  GLN A N   1 
ATOM   203  C  CA  . GLN A 1 33  ? -6.292  -12.893 8.173   1.00 119.70 ? 296  GLN A CA  1 
ATOM   204  C  C   . GLN A 1 33  ? -5.313  -14.079 8.115   1.00 111.71 ? 296  GLN A C   1 
ATOM   205  O  O   . GLN A 1 33  ? -4.134  -13.847 7.782   1.00 94.83  ? 296  GLN A O   1 
ATOM   206  C  CB  . GLN A 1 33  ? -5.761  -11.800 9.109   1.00 108.63 ? 296  GLN A CB  1 
ATOM   207  C  CG  . GLN A 1 33  ? -6.525  -10.485 9.029   1.00 109.97 ? 296  GLN A CG  1 
ATOM   208  C  CD  . GLN A 1 33  ? -5.706  -9.357  8.445   1.00 122.15 ? 296  GLN A CD  1 
ATOM   209  O  OE1 . GLN A 1 33  ? -4.531  -9.175  8.771   1.00 120.56 ? 296  GLN A OE1 1 
ATOM   210  N  NE2 . GLN A 1 33  ? -6.332  -8.565  7.588   1.00 120.97 ? 296  GLN A NE2 1 
ATOM   211  N  N   . ASP A 1 34  ? -5.771  -15.292 8.455   1.00 116.97 ? 297  ASP A N   1 
ATOM   212  C  CA  . ASP A 1 34  ? -5.039  -16.576 8.257   1.00 122.68 ? 297  ASP A CA  1 
ATOM   213  C  C   . ASP A 1 34  ? -5.816  -17.420 7.234   1.00 130.21 ? 297  ASP A C   1 
ATOM   214  O  O   . ASP A 1 34  ? -6.231  -18.548 7.586   1.00 133.53 ? 297  ASP A O   1 
ATOM   215  C  CB  . ASP A 1 34  ? -4.843  -17.328 9.581   1.00 121.66 ? 297  ASP A CB  1 
ATOM   216  C  CG  . ASP A 1 34  ? -3.905  -16.658 10.577  1.00 127.98 ? 297  ASP A CG  1 
ATOM   217  O  OD1 . ASP A 1 34  ? -3.022  -15.880 10.143  1.00 125.14 ? 297  ASP A OD1 1 
ATOM   218  O  OD2 . ASP A 1 34  ? -4.061  -16.926 11.787  1.00 128.60 ? 297  ASP A OD2 1 
ATOM   219  N  N   . HIS A 1 35  ? -6.029  -16.877 6.026   1.00 124.05 ? 298  HIS A N   1 
ATOM   220  C  CA  . HIS A 1 35  ? -6.743  -17.535 4.895   1.00 106.40 ? 298  HIS A CA  1 
ATOM   221  C  C   . HIS A 1 35  ? -5.705  -18.171 3.965   1.00 103.84 ? 298  HIS A C   1 
ATOM   222  O  O   . HIS A 1 35  ? -4.757  -17.502 3.552   1.00 99.60  ? 298  HIS A O   1 
ATOM   223  C  CB  . HIS A 1 35  ? -7.708  -16.547 4.208   1.00 94.88  ? 298  HIS A CB  1 
ATOM   224  C  CG  . HIS A 1 35  ? -7.081  -15.364 3.529   1.00 89.36  ? 298  HIS A CG  1 
ATOM   225  N  ND1 . HIS A 1 35  ? -7.281  -14.066 3.974   1.00 94.61  ? 298  HIS A ND1 1 
ATOM   226  C  CD2 . HIS A 1 35  ? -6.326  -15.259 2.410   1.00 82.04  ? 298  HIS A CD2 1 
ATOM   227  C  CE1 . HIS A 1 35  ? -6.663  -13.219 3.169   1.00 91.34  ? 298  HIS A CE1 1 
ATOM   228  N  NE2 . HIS A 1 35  ? -6.062  -13.926 2.208   1.00 88.42  ? 298  HIS A NE2 1 
ATOM   229  N  N   . PRO A 1 36  ? -5.840  -19.477 3.617   1.00 85.94  ? 299  PRO A N   1 
ATOM   230  C  CA  . PRO A 1 36  ? -4.818  -20.200 2.851   1.00 82.29  ? 299  PRO A CA  1 
ATOM   231  C  C   . PRO A 1 36  ? -4.624  -19.830 1.369   1.00 95.61  ? 299  PRO A C   1 
ATOM   232  O  O   . PRO A 1 36  ? -3.853  -20.504 0.703   1.00 99.65  ? 299  PRO A O   1 
ATOM   233  C  CB  . PRO A 1 36  ? -5.312  -21.655 2.918   1.00 86.55  ? 299  PRO A CB  1 
ATOM   234  C  CG  . PRO A 1 36  ? -6.811  -21.534 3.072   1.00 88.94  ? 299  PRO A CG  1 
ATOM   235  C  CD  . PRO A 1 36  ? -6.976  -20.337 3.978   1.00 87.70  ? 299  PRO A CD  1 
ATOM   236  N  N   . TYR A 1 37  ? -5.293  -18.780 0.884   1.00 98.77  ? 300  TYR A N   1 
ATOM   237  C  CA  . TYR A 1 37  ? -5.366  -18.423 -0.556  1.00 90.14  ? 300  TYR A CA  1 
ATOM   238  C  C   . TYR A 1 37  ? -4.252  -17.435 -0.868  1.00 88.29  ? 300  TYR A C   1 
ATOM   239  O  O   . TYR A 1 37  ? -4.171  -16.407 -0.158  1.00 87.91  ? 300  TYR A O   1 
ATOM   240  C  CB  . TYR A 1 37  ? -6.746  -17.852 -0.906  1.00 82.55  ? 300  TYR A CB  1 
ATOM   241  C  CG  . TYR A 1 37  ? -7.865  -18.706 -0.381  1.00 66.17  ? 300  TYR A CG  1 
ATOM   242  C  CD1 . TYR A 1 37  ? -8.238  -19.878 -1.013  1.00 66.82  ? 300  TYR A CD1 1 
ATOM   243  C  CD2 . TYR A 1 37  ? -8.484  -18.396 0.816   1.00 66.84  ? 300  TYR A CD2 1 
ATOM   244  C  CE1 . TYR A 1 37  ? -9.218  -20.705 -0.483  1.00 63.26  ? 300  TYR A CE1 1 
ATOM   245  C  CE2 . TYR A 1 37  ? -9.467  -19.207 1.359   1.00 56.32  ? 300  TYR A CE2 1 
ATOM   246  C  CZ  . TYR A 1 37  ? -9.838  -20.357 0.703   1.00 53.35  ? 300  TYR A CZ  1 
ATOM   247  O  OH  . TYR A 1 37  ? -10.788 -21.143 1.266   1.00 65.68  ? 300  TYR A OH  1 
ATOM   248  N  N   . LYS A 1 38  ? -3.446  -17.743 -1.891  1.00 86.85  ? 301  LYS A N   1 
ATOM   249  C  CA  . LYS A 1 38  ? -2.566  -16.746 -2.561  1.00 96.74  ? 301  LYS A CA  1 
ATOM   250  C  C   . LYS A 1 38  ? -3.147  -16.337 -3.927  1.00 94.00  ? 301  LYS A C   1 
ATOM   251  O  O   . LYS A 1 38  ? -3.333  -15.129 -4.161  1.00 98.28  ? 301  LYS A O   1 
ATOM   252  C  CB  . LYS A 1 38  ? -1.126  -17.257 -2.712  1.00 99.33  ? 301  LYS A CB  1 
ATOM   253  C  CG  . LYS A 1 38  ? -0.081  -16.182 -3.013  1.00 96.66  ? 301  LYS A CG  1 
ATOM   254  C  CD  . LYS A 1 38  ? 0.199   -15.244 -1.845  1.00 103.58 ? 301  LYS A CD  1 
ATOM   255  C  CE  . LYS A 1 38  ? 0.889   -13.957 -2.255  1.00 114.74 ? 301  LYS A CE  1 
ATOM   256  N  NZ  . LYS A 1 38  ? 2.353   -14.127 -2.432  1.00 116.09 ? 301  LYS A NZ  1 
ATOM   257  N  N   . THR A 1 39  ? -3.450  -17.318 -4.786  0.50 94.01  ? 302  THR A N   1 
ATOM   258  C  CA  . THR A 1 39  ? -3.885  -17.113 -6.197  0.50 91.08  ? 302  THR A CA  1 
ATOM   259  C  C   . THR A 1 39  ? -5.370  -16.731 -6.250  0.50 87.59  ? 302  THR A C   1 
ATOM   260  O  O   . THR A 1 39  ? -5.735  -15.934 -7.137  0.50 85.21  ? 302  THR A O   1 
ATOM   261  C  CB  . THR A 1 39  ? -3.600  -18.357 -7.046  0.50 89.78  ? 302  THR A CB  1 
ATOM   262  O  OG1 . THR A 1 39  ? -4.403  -19.421 -6.538  0.50 90.54  ? 302  THR A OG1 1 
ATOM   263  C  CG2 . THR A 1 39  ? -2.138  -18.749 -7.031  0.50 91.25  ? 302  THR A CG2 1 
ATOM   264  N  N   . TRP A 1 40  ? -6.185  -17.316 -5.372  0.50 79.47  ? 303  TRP A N   1 
ATOM   265  C  CA  . TRP A 1 40  ? -7.619  -16.945 -5.309  0.50 77.06  ? 303  TRP A CA  1 
ATOM   266  C  C   . TRP A 1 40  ? -7.748  -15.623 -4.554  0.50 77.50  ? 303  TRP A C   1 
ATOM   267  O  O   . TRP A 1 40  ? -6.808  -15.281 -3.816  0.50 78.05  ? 303  TRP A O   1 
ATOM   268  C  CB  . TRP A 1 40  ? -8.429  -18.056 -4.636  0.50 74.61  ? 303  TRP A CB  1 
ATOM   269  C  CG  . TRP A 1 40  ? -8.608  -19.277 -5.482  0.50 71.82  ? 303  TRP A CG  1 
ATOM   270  C  CD1 . TRP A 1 40  ? -7.721  -20.299 -5.655  0.50 70.83  ? 303  TRP A CD1 1 
ATOM   271  C  CD2 . TRP A 1 40  ? -9.761  -19.609 -6.274  0.50 71.94  ? 303  TRP A CD2 1 
ATOM   272  N  NE1 . TRP A 1 40  ? -8.242  -21.242 -6.500  0.50 71.34  ? 303  TRP A NE1 1 
ATOM   273  C  CE2 . TRP A 1 40  ? -9.492  -20.846 -6.895  0.50 72.45  ? 303  TRP A CE2 1 
ATOM   274  C  CE3 . TRP A 1 40  ? -10.989 -18.984 -6.517  0.50 72.11  ? 303  TRP A CE3 1 
ATOM   275  C  CZ2 . TRP A 1 40  ? -10.409 -21.465 -7.743  0.50 70.52  ? 303  TRP A CZ2 1 
ATOM   276  C  CZ3 . TRP A 1 40  ? -11.893 -19.597 -7.354  0.50 73.14  ? 303  TRP A CZ3 1 
ATOM   277  C  CH2 . TRP A 1 40  ? -11.605 -20.821 -7.957  0.50 71.29  ? 303  TRP A CH2 1 
ATOM   278  N  N   . ALA A 1 41  ? -8.856  -14.905 -4.743  0.50 78.00  ? 304  ALA A N   1 
ATOM   279  C  CA  . ALA A 1 41  ? -9.091  -13.659 -3.979  0.50 75.25  ? 304  ALA A CA  1 
ATOM   280  C  C   . ALA A 1 41  ? -10.046 -13.971 -2.827  0.50 76.32  ? 304  ALA A C   1 
ATOM   281  O  O   . ALA A 1 41  ? -11.101 -14.563 -3.088  0.50 73.58  ? 304  ALA A O   1 
ATOM   282  C  CB  . ALA A 1 41  ? -9.633  -12.578 -4.876  0.50 70.71  ? 304  ALA A CB  1 
ATOM   283  N  N   . TYR A 1 42  ? -9.667  -13.603 -1.602  1.00 82.63  ? 305  TYR A N   1 
ATOM   284  C  CA  . TYR A 1 42  ? -10.497 -13.896 -0.406  1.00 85.11  ? 305  TYR A CA  1 
ATOM   285  C  C   . TYR A 1 42  ? -11.379 -12.690 -0.106  1.00 87.98  ? 305  TYR A C   1 
ATOM   286  O  O   . TYR A 1 42  ? -10.926 -11.555 -0.319  1.00 107.70 ? 305  TYR A O   1 
ATOM   287  C  CB  . TYR A 1 42  ? -9.613  -14.214 0.798   1.00 84.00  ? 305  TYR A CB  1 
ATOM   288  C  CG  . TYR A 1 42  ? -10.369 -14.498 2.069   1.00 83.23  ? 305  TYR A CG  1 
ATOM   289  C  CD1 . TYR A 1 42  ? -10.996 -15.716 2.265   1.00 72.31  ? 305  TYR A CD1 1 
ATOM   290  C  CD2 . TYR A 1 42  ? -10.461 -13.550 3.073   1.00 75.67  ? 305  TYR A CD2 1 
ATOM   291  C  CE1 . TYR A 1 42  ? -11.696 -15.986 3.427   1.00 79.15  ? 305  TYR A CE1 1 
ATOM   292  C  CE2 . TYR A 1 42  ? -11.157 -13.805 4.242   1.00 75.91  ? 305  TYR A CE2 1 
ATOM   293  C  CZ  . TYR A 1 42  ? -11.777 -15.028 4.419   1.00 81.60  ? 305  TYR A CZ  1 
ATOM   294  O  OH  . TYR A 1 42  ? -12.466 -15.290 5.565   1.00 79.97  ? 305  TYR A OH  1 
ATOM   295  N  N   . HIS A 1 43  ? -12.599 -12.930 0.370   1.00 87.24  ? 306  HIS A N   1 
ATOM   296  C  CA  . HIS A 1 43  ? -13.534 -11.799 0.590   1.00 86.25  ? 306  HIS A CA  1 
ATOM   297  C  C   . HIS A 1 43  ? -14.111 -11.844 2.009   1.00 83.98  ? 306  HIS A C   1 
ATOM   298  O  O   . HIS A 1 43  ? -14.400 -10.765 2.547   1.00 99.79  ? 306  HIS A O   1 
ATOM   299  C  CB  . HIS A 1 43  ? -14.612 -11.790 -0.502  1.00 79.36  ? 306  HIS A CB  1 
ATOM   300  C  CG  . HIS A 1 43  ? -14.088 -11.599 -1.883  1.00 66.42  ? 306  HIS A CG  1 
ATOM   301  N  ND1 . HIS A 1 43  ? -13.696 -10.367 -2.357  1.00 64.88  ? 306  HIS A ND1 1 
ATOM   302  C  CD2 . HIS A 1 43  ? -13.909 -12.470 -2.897  1.00 68.85  ? 306  HIS A CD2 1 
ATOM   303  C  CE1 . HIS A 1 43  ? -13.287 -10.487 -3.602  1.00 63.57  ? 306  HIS A CE1 1 
ATOM   304  N  NE2 . HIS A 1 43  ? -13.409 -11.766 -3.956  1.00 68.82  ? 306  HIS A NE2 1 
ATOM   305  N  N   . GLY A 1 44  ? -14.296 -13.034 2.579   1.00 72.54  ? 307  GLY A N   1 
ATOM   306  C  CA  . GLY A 1 44  ? -14.910 -13.123 3.914   1.00 73.72  ? 307  GLY A CA  1 
ATOM   307  C  C   . GLY A 1 44  ? -15.368 -14.523 4.248   1.00 79.12  ? 307  GLY A C   1 
ATOM   308  O  O   . GLY A 1 44  ? -15.152 -15.418 3.420   1.00 83.18  ? 307  GLY A O   1 
ATOM   309  N  N   . SER A 1 45  ? -15.995 -14.702 5.413   0.50 78.86  ? 308  SER A N   1 
ATOM   310  C  CA  . SER A 1 45  ? -16.405 -16.061 5.849   0.50 80.60  ? 308  SER A CA  1 
ATOM   311  C  C   . SER A 1 45  ? -17.694 -16.009 6.670   0.50 85.73  ? 308  SER A C   1 
ATOM   312  O  O   . SER A 1 45  ? -18.172 -14.894 6.939   0.50 90.28  ? 308  SER A O   1 
ATOM   313  C  CB  . SER A 1 45  ? -15.301 -16.726 6.625   0.50 80.86  ? 308  SER A CB  1 
ATOM   314  O  OG  . SER A 1 45  ? -14.178 -16.979 5.796   0.50 77.00  ? 308  SER A OG  1 
ATOM   315  N  N   . TYR A 1 46  ? -18.224 -17.174 7.052   0.50 88.93  ? 309  TYR A N   1 
ATOM   316  C  CA  . TYR A 1 46  ? -19.473 -17.274 7.855   0.50 91.00  ? 309  TYR A CA  1 
ATOM   317  C  C   . TYR A 1 46  ? -19.636 -18.724 8.336   0.50 94.97  ? 309  TYR A C   1 
ATOM   318  O  O   . TYR A 1 46  ? -18.792 -19.565 7.982   0.50 98.30  ? 309  TYR A O   1 
ATOM   319  C  CB  . TYR A 1 46  ? -20.669 -16.731 7.062   0.50 90.31  ? 309  TYR A CB  1 
ATOM   320  C  CG  . TYR A 1 46  ? -21.081 -17.532 5.851   0.50 87.39  ? 309  TYR A CG  1 
ATOM   321  C  CD1 . TYR A 1 46  ? -21.855 -18.673 5.982   0.50 87.57  ? 309  TYR A CD1 1 
ATOM   322  C  CD2 . TYR A 1 46  ? -20.733 -17.131 4.570   0.50 86.48  ? 309  TYR A CD2 1 
ATOM   323  C  CE1 . TYR A 1 46  ? -22.251 -19.411 4.879   0.50 89.32  ? 309  TYR A CE1 1 
ATOM   324  C  CE2 . TYR A 1 46  ? -21.121 -17.858 3.455   0.50 86.76  ? 309  TYR A CE2 1 
ATOM   325  C  CZ  . TYR A 1 46  ? -21.883 -19.003 3.609   0.50 88.09  ? 309  TYR A CZ  1 
ATOM   326  O  OH  . TYR A 1 46  ? -22.277 -19.734 2.525   0.50 85.01  ? 309  TYR A OH  1 
ATOM   327  N  N   . GLU A 1 47  ? -20.685 -19.002 9.118   0.50 103.32 ? 310  GLU A N   1 
ATOM   328  C  CA  . GLU A 1 47  ? -20.822 -20.232 9.951   0.50 110.41 ? 310  GLU A CA  1 
ATOM   329  C  C   . GLU A 1 47  ? -21.626 -21.312 9.210   0.50 117.61 ? 310  GLU A C   1 
ATOM   330  O  O   . GLU A 1 47  ? -22.751 -21.012 8.755   0.50 122.15 ? 310  GLU A O   1 
ATOM   331  C  CB  . GLU A 1 47  ? -21.474 -19.865 11.288  0.50 113.53 ? 310  GLU A CB  1 
ATOM   332  C  CG  . GLU A 1 47  ? -21.528 -21.009 12.287  0.50 113.73 ? 310  GLU A CG  1 
ATOM   333  C  CD  . GLU A 1 47  ? -21.607 -20.572 13.741  0.50 112.01 ? 310  GLU A CD  1 
ATOM   334  O  OE1 . GLU A 1 47  ? -22.722 -20.594 14.308  0.50 106.23 ? 310  GLU A OE1 1 
ATOM   335  O  OE2 . GLU A 1 47  ? -20.550 -20.217 14.306  0.50 108.42 ? 310  GLU A OE2 1 
ATOM   336  N  N   . THR A 1 48  ? -21.065 -22.526 9.119   0.50 122.18 ? 311  THR A N   1 
ATOM   337  C  CA  . THR A 1 48  ? -21.698 -23.742 8.533   0.50 123.94 ? 311  THR A CA  1 
ATOM   338  C  C   . THR A 1 48  ? -21.072 -24.996 9.160   0.50 127.68 ? 311  THR A C   1 
ATOM   339  O  O   . THR A 1 48  ? -20.382 -24.857 10.194  0.50 130.01 ? 311  THR A O   1 
ATOM   340  C  CB  . THR A 1 48  ? -21.553 -23.773 7.005   0.50 123.62 ? 311  THR A CB  1 
ATOM   341  O  OG1 . THR A 1 48  ? -20.180 -23.554 6.680   0.50 123.93 ? 311  THR A OG1 1 
ATOM   342  C  CG2 . THR A 1 48  ? -22.406 -22.739 6.302   0.50 124.31 ? 311  THR A CG2 1 
ATOM   343  N  N   . LYS A 1 49  ? -21.305 -26.166 8.552   0.50 128.09 ? 312  LYS A N   1 
ATOM   344  C  CA  . LYS A 1 49  ? -20.718 -27.474 8.960   0.50 123.64 ? 312  LYS A CA  1 
ATOM   345  C  C   . LYS A 1 49  ? -21.338 -28.598 8.117   0.50 120.79 ? 312  LYS A C   1 
ATOM   346  O  O   . LYS A 1 49  ? -22.426 -29.076 8.501   0.50 114.44 ? 312  LYS A O   1 
ATOM   347  C  CB  . LYS A 1 49  ? -20.928 -27.709 10.459  0.50 122.42 ? 312  LYS A CB  1 
ATOM   348  C  CG  . LYS A 1 49  ? -19.824 -27.170 11.361  0.50 117.90 ? 312  LYS A CG  1 
ATOM   349  C  CD  . LYS A 1 49  ? -20.172 -27.220 12.834  0.50 115.41 ? 312  LYS A CD  1 
ATOM   350  C  CE  . LYS A 1 49  ? -21.267 -26.244 13.210  0.50 114.70 ? 312  LYS A CE  1 
ATOM   351  N  NZ  . LYS A 1 49  ? -21.841 -26.552 14.541  0.50 115.46 ? 312  LYS A NZ  1 
ATOM   352  N  N   . SER A 1 55  ? -19.551 -40.977 0.448   1.00 136.76 ? 318  SER A N   1 
ATOM   353  C  CA  . SER A 1 55  ? -18.485 -41.945 0.060   1.00 119.50 ? 318  SER A CA  1 
ATOM   354  C  C   . SER A 1 55  ? -19.064 -43.040 -0.857  1.00 110.37 ? 318  SER A C   1 
ATOM   355  O  O   . SER A 1 55  ? -20.309 -43.106 -1.035  1.00 97.61  ? 318  SER A O   1 
ATOM   356  C  CB  . SER A 1 55  ? -17.791 -42.532 1.284   1.00 107.66 ? 318  SER A CB  1 
ATOM   357  O  OG  . SER A 1 55  ? -18.604 -43.486 1.959   1.00 95.85  ? 318  SER A OG  1 
ATOM   358  N  N   . SER A 1 56  ? -18.179 -43.851 -1.440  1.00 93.92  ? 319  SER A N   1 
ATOM   359  C  CA  . SER A 1 56  ? -18.504 -44.962 -2.367  1.00 88.53  ? 319  SER A CA  1 
ATOM   360  C  C   . SER A 1 56  ? -18.994 -46.168 -1.552  1.00 86.73  ? 319  SER A C   1 
ATOM   361  O  O   . SER A 1 56  ? -18.263 -46.601 -0.635  1.00 75.83  ? 319  SER A O   1 
ATOM   362  C  CB  . SER A 1 56  ? -17.300 -45.315 -3.221  1.00 99.74  ? 319  SER A CB  1 
ATOM   363  O  OG  . SER A 1 56  ? -16.425 -46.229 -2.549  1.00 88.40  ? 319  SER A OG  1 
ATOM   364  N  N   . MET A 1 57  ? -20.166 -46.714 -1.898  1.00 72.71  ? 320  MET A N   1 
ATOM   365  C  CA  . MET A 1 57  ? -20.736 -47.941 -1.269  1.00 56.36  ? 320  MET A CA  1 
ATOM   366  C  C   . MET A 1 57  ? -20.493 -49.148 -2.196  1.00 42.71  ? 320  MET A C   1 
ATOM   367  O  O   . MET A 1 57  ? -20.283 -48.946 -3.407  1.00 42.49  ? 320  MET A O   1 
ATOM   368  C  CB  . MET A 1 57  ? -22.223 -47.702 -1.031  1.00 68.32  ? 320  MET A CB  1 
ATOM   369  C  CG  . MET A 1 57  ? -22.512 -46.269 -0.520  1.00 74.66  ? 320  MET A CG  1 
ATOM   370  S  SD  . MET A 1 57  ? -21.702 -45.893 1.087   1.00 72.16  ? 320  MET A SD  1 
ATOM   371  C  CE  . MET A 1 57  ? -22.834 -46.741 2.198   1.00 63.55  ? 320  MET A CE  1 
ATOM   372  N  N   . VAL A 1 58  ? -20.452 -50.365 -1.675  1.00 35.46  ? 321  VAL A N   1 
ATOM   373  C  CA  . VAL A 1 58  ? -20.253 -51.580 -2.518  1.00 37.18  ? 321  VAL A CA  1 
ATOM   374  C  C   . VAL A 1 58  ? -21.606 -52.115 -2.995  1.00 36.50  ? 321  VAL A C   1 
ATOM   375  O  O   . VAL A 1 58  ? -22.509 -52.190 -2.177  1.00 39.04  ? 321  VAL A O   1 
ATOM   376  C  CB  . VAL A 1 58  ? -19.467 -52.680 -1.783  1.00 39.11  ? 321  VAL A CB  1 
ATOM   377  C  CG1 . VAL A 1 58  ? -19.306 -53.931 -2.655  1.00 37.50  ? 321  VAL A CG1 1 
ATOM   378  C  CG2 . VAL A 1 58  ? -18.124 -52.165 -1.311  1.00 43.19  ? 321  VAL A CG2 1 
ATOM   379  N  N   . ASN A 1 59  ? -21.702 -52.435 -4.280  1.00 29.39  ? 322  ASN A N   1 
ATOM   380  C  CA  . ASN A 1 59  ? -22.806 -53.164 -4.914  1.00 29.59  ? 322  ASN A CA  1 
ATOM   381  C  C   . ASN A 1 59  ? -22.650 -54.637 -4.576  1.00 30.55  ? 322  ASN A C   1 
ATOM   382  O  O   . ASN A 1 59  ? -21.777 -55.308 -5.183  1.00 32.69  ? 322  ASN A O   1 
ATOM   383  C  CB  . ASN A 1 59  ? -22.787 -52.931 -6.433  1.00 30.30  ? 322  ASN A CB  1 
ATOM   384  C  CG  . ASN A 1 59  ? -23.998 -53.557 -7.111  1.00 31.17  ? 322  ASN A CG  1 
ATOM   385  O  OD1 . ASN A 1 59  ? -24.422 -54.667 -6.762  1.00 28.30  ? 322  ASN A OD1 1 
ATOM   386  N  ND2 . ASN A 1 59  ? -24.597 -52.826 -8.039  1.00 31.15  ? 322  ASN A ND2 1 
ATOM   387  N  N   . GLY A 1 60  ? -23.481 -55.142 -3.687  1.00 31.28  ? 323  GLY A N   1 
ATOM   388  C  CA  . GLY A 1 60  ? -23.417 -56.530 -3.199  1.00 31.07  ? 323  GLY A CA  1 
ATOM   389  C  C   . GLY A 1 60  ? -23.789 -57.557 -4.272  1.00 35.17  ? 323  GLY A C   1 
ATOM   390  O  O   . GLY A 1 60  ? -23.224 -58.681 -4.333  1.00 35.41  ? 323  GLY A O   1 
ATOM   391  N  N   . VAL A 1 61  ? -24.676 -57.198 -5.170  1.00 33.78  ? 324  VAL A N   1 
ATOM   392  C  CA  . VAL A 1 61  ? -25.043 -58.141 -6.250  1.00 31.36  ? 324  VAL A CA  1 
ATOM   393  C  C   . VAL A 1 61  ? -23.774 -58.442 -7.041  1.00 29.76  ? 324  VAL A C   1 
ATOM   394  O  O   . VAL A 1 61  ? -23.493 -59.621 -7.233  1.00 30.68  ? 324  VAL A O   1 
ATOM   395  C  CB  . VAL A 1 61  ? -26.213 -57.591 -7.077  1.00 28.21  ? 324  VAL A CB  1 
ATOM   396  C  CG1 . VAL A 1 61  ? -26.440 -58.352 -8.347  1.00 26.79  ? 324  VAL A CG1 1 
ATOM   397  C  CG2 . VAL A 1 61  ? -27.479 -57.577 -6.231  1.00 29.81  ? 324  VAL A CG2 1 
ATOM   398  N  N   . VAL A 1 62  ? -23.041 -57.423 -7.504  1.00 32.76  ? 325  VAL A N   1 
ATOM   399  C  CA  . VAL A 1 62  ? -21.826 -57.628 -8.350  1.00 32.18  ? 325  VAL A CA  1 
ATOM   400  C  C   . VAL A 1 62  ? -20.754 -58.325 -7.503  1.00 31.09  ? 325  VAL A C   1 
ATOM   401  O  O   . VAL A 1 62  ? -20.175 -59.280 -7.977  1.00 27.24  ? 325  VAL A O   1 
ATOM   402  C  CB  . VAL A 1 62  ? -21.273 -56.326 -8.946  1.00 30.77  ? 325  VAL A CB  1 
ATOM   403  C  CG1 . VAL A 1 62  ? -19.975 -56.572 -9.686  1.00 30.68  ? 325  VAL A CG1 1 
ATOM   404  C  CG2 . VAL A 1 62  ? -22.278 -55.685 -9.872  1.00 30.76  ? 325  VAL A CG2 1 
ATOM   405  N  N   . ARG A 1 63  ? -20.562 -57.913 -6.259  1.00 28.49  ? 326  ARG A N   1 
ATOM   406  C  CA  . ARG A 1 63  ? -19.483 -58.495 -5.459  1.00 29.84  ? 326  ARG A CA  1 
ATOM   407  C  C   . ARG A 1 63  ? -19.751 -59.986 -5.227  1.00 32.00  ? 326  ARG A C   1 
ATOM   408  O  O   . ARG A 1 63  ? -18.774 -60.805 -5.303  1.00 29.96  ? 326  ARG A O   1 
ATOM   409  C  CB  . ARG A 1 63  ? -19.240 -57.702 -4.190  1.00 27.78  ? 326  ARG A CB  1 
ATOM   410  C  CG  . ARG A 1 63  ? -18.230 -58.397 -3.295  1.00 27.17  ? 326  ARG A CG  1 
ATOM   411  C  CD  . ARG A 1 63  ? -17.539 -57.455 -2.333  1.00 25.10  ? 326  ARG A CD  1 
ATOM   412  N  NE  . ARG A 1 63  ? -18.400 -56.974 -1.284  1.00 28.91  ? 326  ARG A NE  1 
ATOM   413  C  CZ  . ARG A 1 63  ? -18.037 -56.157 -0.301  1.00 30.92  ? 326  ARG A CZ  1 
ATOM   414  N  NH1 . ARG A 1 63  ? -16.767 -55.772 -0.164  1.00 31.63  ? 326  ARG A NH1 1 
ATOM   415  N  NH2 . ARG A 1 63  ? -18.961 -55.708 0.542   1.00 31.68  ? 326  ARG A NH2 1 
ATOM   416  N  N   . LEU A 1 64  ? -20.979 -60.381 -4.916  1.00 28.77  ? 327  LEU A N   1 
ATOM   417  C  CA  . LEU A 1 64  ? -21.261 -61.814 -4.602  1.00 28.75  ? 327  LEU A CA  1 
ATOM   418  C  C   . LEU A 1 64  ? -21.008 -62.636 -5.870  1.00 27.24  ? 327  LEU A C   1 
ATOM   419  O  O   . LEU A 1 64  ? -20.711 -63.836 -5.772  1.00 29.68  ? 327  LEU A O   1 
ATOM   420  C  CB  . LEU A 1 64  ? -22.712 -61.989 -4.122  1.00 31.37  ? 327  LEU A CB  1 
ATOM   421  C  CG  . LEU A 1 64  ? -22.974 -61.665 -2.647  1.00 32.97  ? 327  LEU A CG  1 
ATOM   422  C  CD1 . LEU A 1 64  ? -24.462 -61.877 -2.316  1.00 36.01  ? 327  LEU A CD1 1 
ATOM   423  C  CD2 . LEU A 1 64  ? -22.123 -62.486 -1.688  1.00 32.45  ? 327  LEU A CD2 1 
ATOM   424  N  N   . LEU A 1 65  ? -21.111 -62.042 -7.052  1.00 29.22  ? 328  LEU A N   1 
ATOM   425  C  CA  . LEU A 1 65  ? -20.914 -62.823 -8.314  1.00 28.99  ? 328  LEU A CA  1 
ATOM   426  C  C   . LEU A 1 65  ? -19.486 -62.657 -8.881  1.00 28.48  ? 328  LEU A C   1 
ATOM   427  O  O   . LEU A 1 65  ? -19.215 -63.209 -9.967  1.00 28.03  ? 328  LEU A O   1 
ATOM   428  C  CB  . LEU A 1 65  ? -22.017 -62.415 -9.286  1.00 30.16  ? 328  LEU A CB  1 
ATOM   429  C  CG  . LEU A 1 65  ? -23.419 -62.798 -8.791  1.00 31.77  ? 328  LEU A CG  1 
ATOM   430  C  CD1 . LEU A 1 65  ? -24.530 -62.196 -9.615  1.00 30.47  ? 328  LEU A CD1 1 
ATOM   431  C  CD2 . LEU A 1 65  ? -23.572 -64.293 -8.743  1.00 36.35  ? 328  LEU A CD2 1 
ATOM   432  N  N   . THR A 1 66  ? -18.581 -62.016 -8.142  1.00 25.00  ? 329  THR A N   1 
ATOM   433  C  CA  . THR A 1 66  ? -17.161 -61.840 -8.543  1.00 26.19  ? 329  THR A CA  1 
ATOM   434  C  C   . THR A 1 66  ? -16.266 -62.194 -7.344  1.00 27.48  ? 329  THR A C   1 
ATOM   435  O  O   . THR A 1 66  ? -15.266 -61.482 -7.074  1.00 29.65  ? 329  THR A O   1 
ATOM   436  C  CB  . THR A 1 66  ? -16.910 -60.423 -9.098  1.00 26.36  ? 329  THR A CB  1 
ATOM   437  O  OG1 . THR A 1 66  ? -17.310 -59.426 -8.138  1.00 25.04  ? 329  THR A OG1 1 
ATOM   438  C  CG2 . THR A 1 66  ? -17.623 -60.225 -10.417 1.00 26.70  ? 329  THR A CG2 1 
ATOM   439  N  N   . LYS A 1 67  ? -16.502 -63.332 -6.731  1.00 24.63  ? 330  LYS A N   1 
ATOM   440  C  CA  . LYS A 1 67  ? -15.777 -63.752 -5.511  1.00 28.88  ? 330  LYS A CA  1 
ATOM   441  C  C   . LYS A 1 67  ? -14.250 -63.863 -5.711  1.00 28.20  ? 330  LYS A C   1 
ATOM   442  O  O   . LYS A 1 67  ? -13.527 -63.499 -4.804  1.00 28.90  ? 330  LYS A O   1 
ATOM   443  C  CB  . LYS A 1 67  ? -16.359 -65.068 -5.023  1.00 32.16  ? 330  LYS A CB  1 
ATOM   444  C  CG  . LYS A 1 67  ? -15.815 -65.524 -3.694  1.00 33.46  ? 330  LYS A CG  1 
ATOM   445  C  CD  . LYS A 1 67  ? -16.339 -66.838 -3.234  1.00 36.90  ? 330  LYS A CD  1 
ATOM   446  C  CE  . LYS A 1 67  ? -16.471 -66.815 -1.729  1.00 46.21  ? 330  LYS A CE  1 
ATOM   447  N  NZ  . LYS A 1 67  ? -16.206 -68.149 -1.172  1.00 51.92  ? 330  LYS A NZ  1 
ATOM   448  N  N   . PRO A 1 68  ? -13.667 -64.384 -6.800  1.00 26.62  ? 331  PRO A N   1 
ATOM   449  C  CA  . PRO A 1 68  ? -12.211 -64.450 -6.905  1.00 29.97  ? 331  PRO A CA  1 
ATOM   450  C  C   . PRO A 1 68  ? -11.547 -63.071 -6.689  1.00 35.65  ? 331  PRO A C   1 
ATOM   451  O  O   . PRO A 1 68  ? -10.408 -63.023 -6.232  1.00 25.93  ? 331  PRO A O   1 
ATOM   452  C  CB  . PRO A 1 68  ? -11.909 -64.989 -8.322  1.00 29.53  ? 331  PRO A CB  1 
ATOM   453  C  CG  . PRO A 1 68  ? -13.174 -65.781 -8.651  1.00 29.44  ? 331  PRO A CG  1 
ATOM   454  C  CD  . PRO A 1 68  ? -14.318 -65.104 -7.890  1.00 29.63  ? 331  PRO A CD  1 
ATOM   455  N  N   . TRP A 1 69  ? -12.289 -61.980 -6.921  1.00 30.78  ? 332  TRP A N   1 
ATOM   456  C  CA  . TRP A 1 69  ? -11.682 -60.633 -6.911  1.00 30.82  ? 332  TRP A CA  1 
ATOM   457  C  C   . TRP A 1 69  ? -11.697 -60.086 -5.483  1.00 33.96  ? 332  TRP A C   1 
ATOM   458  O  O   . TRP A 1 69  ? -11.051 -59.059 -5.250  1.00 31.41  ? 332  TRP A O   1 
ATOM   459  C  CB  . TRP A 1 69  ? -12.361 -59.764 -7.980  1.00 32.69  ? 332  TRP A CB  1 
ATOM   460  C  CG  . TRP A 1 69  ? -11.974 -60.199 -9.358  1.00 28.90  ? 332  TRP A CG  1 
ATOM   461  C  CD1 . TRP A 1 69  ? -10.881 -59.765 -10.036 1.00 27.90  ? 332  TRP A CD1 1 
ATOM   462  C  CD2 . TRP A 1 69  ? -12.588 -61.202 -10.197 1.00 27.42  ? 332  TRP A CD2 1 
ATOM   463  N  NE1 . TRP A 1 69  ? -10.780 -60.419 -11.235 1.00 30.11  ? 332  TRP A NE1 1 
ATOM   464  C  CE2 . TRP A 1 69  ? -11.820 -61.288 -11.368 1.00 28.37  ? 332  TRP A CE2 1 
ATOM   465  C  CE3 . TRP A 1 69  ? -13.697 -62.040 -10.077 1.00 29.36  ? 332  TRP A CE3 1 
ATOM   466  C  CZ2 . TRP A 1 69  ? -12.111 -62.164 -12.404 1.00 30.68  ? 332  TRP A CZ2 1 
ATOM   467  C  CZ3 . TRP A 1 69  ? -14.011 -62.884 -11.117 1.00 28.37  ? 332  TRP A CZ3 1 
ATOM   468  C  CH2 . TRP A 1 69  ? -13.195 -62.981 -12.238 1.00 31.00  ? 332  TRP A CH2 1 
ATOM   469  N  N   . ASP A 1 70  ? -12.302 -60.805 -4.526  1.00 29.95  ? 333  ASP A N   1 
ATOM   470  C  CA  . ASP A 1 70  ? -12.351 -60.348 -3.114  1.00 28.47  ? 333  ASP A CA  1 
ATOM   471  C  C   . ASP A 1 70  ? -10.949 -60.304 -2.495  1.00 30.21  ? 333  ASP A C   1 
ATOM   472  O  O   . ASP A 1 70  ? -10.805 -59.748 -1.329  1.00 33.61  ? 333  ASP A O   1 
ATOM   473  C  CB  . ASP A 1 70  ? -13.258 -61.274 -2.296  1.00 33.04  ? 333  ASP A CB  1 
ATOM   474  C  CG  . ASP A 1 70  ? -14.742 -61.134 -2.607  1.00 32.25  ? 333  ASP A CG  1 
ATOM   475  O  OD1 . ASP A 1 70  ? -15.120 -60.244 -3.452  1.00 32.06  ? 333  ASP A OD1 1 
ATOM   476  O  OD2 . ASP A 1 70  ? -15.521 -61.929 -2.024  1.00 32.51  ? 333  ASP A OD2 1 
ATOM   477  N  N   . ILE A 1 71  ? -9.964  -60.925 -3.154  1.00 29.76  ? 334  ILE A N   1 
ATOM   478  C  CA  . ILE A 1 71  ? -8.572  -61.057 -2.627  1.00 28.53  ? 334  ILE A CA  1 
ATOM   479  C  C   . ILE A 1 71  ? -7.581  -60.310 -3.551  1.00 34.51  ? 334  ILE A C   1 
ATOM   480  O  O   . ILE A 1 71  ? -6.361  -60.416 -3.289  1.00 38.55  ? 334  ILE A O   1 
ATOM   481  C  CB  . ILE A 1 71  ? -8.183  -62.532 -2.387  1.00 29.64  ? 334  ILE A CB  1 
ATOM   482  C  CG1 . ILE A 1 71  ? -8.197  -63.386 -3.654  1.00 31.81  ? 334  ILE A CG1 1 
ATOM   483  C  CG2 . ILE A 1 71  ? -8.999  -63.176 -1.305  1.00 29.73  ? 334  ILE A CG2 1 
ATOM   484  C  CD1 . ILE A 1 71  ? -7.491  -64.690 -3.498  1.00 39.31  ? 334  ILE A CD1 1 
ATOM   485  N  N   . ILE A 1 72  ? -8.040  -59.555 -4.567  1.00 31.94  ? 335  ILE A N   1 
ATOM   486  C  CA  . ILE A 1 72  ? -7.183  -58.764 -5.490  1.00 28.71  ? 335  ILE A CA  1 
ATOM   487  C  C   . ILE A 1 72  ? -7.181  -57.322 -5.004  1.00 36.05  ? 335  ILE A C   1 
ATOM   488  O  O   . ILE A 1 72  ? -8.189  -56.609 -5.140  1.00 33.05  ? 335  ILE A O   1 
ATOM   489  C  CB  . ILE A 1 72  ? -7.711  -58.850 -6.930  1.00 36.82  ? 335  ILE A CB  1 
ATOM   490  C  CG1 . ILE A 1 72  ? -7.851  -60.283 -7.454  1.00 35.27  ? 335  ILE A CG1 1 
ATOM   491  C  CG2 . ILE A 1 72  ? -6.938  -57.937 -7.881  1.00 35.45  ? 335  ILE A CG2 1 
ATOM   492  C  CD1 . ILE A 1 72  ? -6.594  -61.039 -7.512  1.00 40.34  ? 335  ILE A CD1 1 
ATOM   493  N  N   . PRO A 1 73  ? -6.071  -56.843 -4.384  1.00 38.56  ? 336  PRO A N   1 
ATOM   494  C  CA  . PRO A 1 73  ? -5.995  -55.480 -3.852  1.00 35.38  ? 336  PRO A CA  1 
ATOM   495  C  C   . PRO A 1 73  ? -6.328  -54.361 -4.847  1.00 35.87  ? 336  PRO A C   1 
ATOM   496  O  O   . PRO A 1 73  ? -6.985  -53.445 -4.467  1.00 37.04  ? 336  PRO A O   1 
ATOM   497  C  CB  . PRO A 1 73  ? -4.530  -55.347 -3.447  1.00 46.20  ? 336  PRO A CB  1 
ATOM   498  C  CG  . PRO A 1 73  ? -4.167  -56.764 -3.060  1.00 49.29  ? 336  PRO A CG  1 
ATOM   499  C  CD  . PRO A 1 73  ? -4.862  -57.627 -4.099  1.00 42.04  ? 336  PRO A CD  1 
ATOM   500  N  N   . MET A 1 74  ? -5.991  -54.497 -6.119  1.00 34.77  ? 337  MET A N   1 
ATOM   501  C  CA  . MET A 1 74  ? -6.353  -53.463 -7.117  1.00 39.60  ? 337  MET A CA  1 
ATOM   502  C  C   . MET A 1 74  ? -7.882  -53.328 -7.170  1.00 41.87  ? 337  MET A C   1 
ATOM   503  O  O   . MET A 1 74  ? -8.348  -52.201 -7.310  1.00 41.04  ? 337  MET A O   1 
ATOM   504  C  CB  . MET A 1 74  ? -5.784  -53.829 -8.487  1.00 49.26  ? 337  MET A CB  1 
ATOM   505  C  CG  . MET A 1 74  ? -4.238  -53.761 -8.513  1.00 64.57  ? 337  MET A CG  1 
ATOM   506  S  SD  . MET A 1 74  ? -3.587  -52.071 -8.073  1.00 79.86  ? 337  MET A SD  1 
ATOM   507  C  CE  . MET A 1 74  ? -4.535  -51.077 -9.231  1.00 69.66  ? 337  MET A CE  1 
ATOM   508  N  N   . VAL A 1 75  ? -8.640  -54.425 -7.014  1.00 32.72  ? 338  VAL A N   1 
ATOM   509  C  CA  . VAL A 1 75  ? -10.139 -54.364 -7.014  1.00 30.73  ? 338  VAL A CA  1 
ATOM   510  C  C   . VAL A 1 75  ? -10.627 -53.801 -5.683  1.00 30.66  ? 338  VAL A C   1 
ATOM   511  O  O   . VAL A 1 75  ? -11.407 -52.890 -5.720  1.00 32.75  ? 338  VAL A O   1 
ATOM   512  C  CB  . VAL A 1 75  ? -10.809 -55.717 -7.329  1.00 29.22  ? 338  VAL A CB  1 
ATOM   513  C  CG1 . VAL A 1 75  ? -12.313 -55.705 -7.014  1.00 32.41  ? 338  VAL A CG1 1 
ATOM   514  C  CG2 . VAL A 1 75  ? -10.587 -56.093 -8.790  1.00 28.87  ? 338  VAL A CG2 1 
ATOM   515  N  N   . THR A 1 76  ? -10.231 -54.382 -4.558  1.00 32.68  ? 339  THR A N   1 
ATOM   516  C  CA  . THR A 1 76  ? -10.802 -54.110 -3.219  1.00 33.10  ? 339  THR A CA  1 
ATOM   517  C  C   . THR A 1 76  ? -10.452 -52.699 -2.753  1.00 34.40  ? 339  THR A C   1 
ATOM   518  O  O   . THR A 1 76  ? -11.324 -52.074 -2.099  1.00 37.40  ? 339  THR A O   1 
ATOM   519  C  CB  . THR A 1 76  ? -10.313 -55.140 -2.192  1.00 39.72  ? 339  THR A CB  1 
ATOM   520  O  OG1 . THR A 1 76  ? -8.882  -55.135 -2.096  1.00 40.46  ? 339  THR A OG1 1 
ATOM   521  C  CG2 . THR A 1 76  ? -10.781 -56.524 -2.573  1.00 43.57  ? 339  THR A CG2 1 
ATOM   522  N  N   . GLN A 1 77  ? -9.261  -52.197 -3.091  1.00 35.40  ? 340  GLN A N   1 
ATOM   523  C  CA  . GLN A 1 77  ? -8.840  -50.833 -2.668  1.00 41.76  ? 340  GLN A CA  1 
ATOM   524  C  C   . GLN A 1 77  ? -9.654  -49.767 -3.395  1.00 35.10  ? 340  GLN A C   1 
ATOM   525  O  O   . GLN A 1 77  ? -9.746  -48.678 -2.851  1.00 37.60  ? 340  GLN A O   1 
ATOM   526  C  CB  . GLN A 1 77  ? -7.361  -50.561 -2.910  1.00 41.96  ? 340  GLN A CB  1 
ATOM   527  C  CG  . GLN A 1 77  ? -6.483  -51.663 -2.375  1.00 54.10  ? 340  GLN A CG  1 
ATOM   528  C  CD  . GLN A 1 77  ? -6.008  -51.377 -0.985  1.00 66.04  ? 340  GLN A CD  1 
ATOM   529  O  OE1 . GLN A 1 77  ? -6.753  -50.841 -0.170  1.00 68.99  ? 340  GLN A OE1 1 
ATOM   530  N  NE2 . GLN A 1 77  ? -4.759  -51.740 -0.727  1.00 75.35  ? 340  GLN A NE2 1 
ATOM   531  N  N   . MET A 1 78  ? -10.187 -50.038 -4.583  1.00 36.74  ? 341  MET A N   1 
ATOM   532  C  CA  . MET A 1 78  ? -10.931 -48.993 -5.335  1.00 39.62  ? 341  MET A CA  1 
ATOM   533  C  C   . MET A 1 78  ? -12.137 -48.572 -4.519  1.00 44.30  ? 341  MET A C   1 
ATOM   534  O  O   . MET A 1 78  ? -12.578 -47.424 -4.748  1.00 41.95  ? 341  MET A O   1 
ATOM   535  C  CB  . MET A 1 78  ? -11.442 -49.410 -6.711  1.00 42.32  ? 341  MET A CB  1 
ATOM   536  C  CG  . MET A 1 78  ? -10.323 -49.610 -7.715  1.00 49.23  ? 341  MET A CG  1 
ATOM   537  S  SD  . MET A 1 78  ? -10.962 -49.910 -9.393  1.00 50.07  ? 341  MET A SD  1 
ATOM   538  C  CE  . MET A 1 78  ? -12.195 -48.606 -9.410  1.00 43.12  ? 341  MET A CE  1 
ATOM   539  N  N   . ALA A 1 79  ? -12.664 -49.448 -3.638  1.00 40.20  ? 342  ALA A N   1 
ATOM   540  C  CA  . ALA A 1 79  ? -13.915 -49.154 -2.893  1.00 42.94  ? 342  ALA A CA  1 
ATOM   541  C  C   . ALA A 1 79  ? -13.631 -48.427 -1.568  1.00 42.79  ? 342  ALA A C   1 
ATOM   542  O  O   . ALA A 1 79  ? -14.605 -48.094 -0.899  1.00 42.59  ? 342  ALA A O   1 
ATOM   543  C  CB  . ALA A 1 79  ? -14.697 -50.437 -2.672  1.00 41.61  ? 342  ALA A CB  1 
ATOM   544  N  N   . MET A 1 80  ? -12.373 -48.204 -1.177  1.00 43.64  ? 343  MET A N   1 
ATOM   545  C  CA  . MET A 1 80  ? -12.055 -47.531 0.120   1.00 54.91  ? 343  MET A CA  1 
ATOM   546  C  C   . MET A 1 80  ? -11.858 -46.024 -0.108  1.00 60.36  ? 343  MET A C   1 
ATOM   547  O  O   . MET A 1 80  ? -11.924 -45.608 -1.269  1.00 64.99  ? 343  MET A O   1 
ATOM   548  C  CB  . MET A 1 80  ? -10.801 -48.127 0.765   1.00 49.99  ? 343  MET A CB  1 
ATOM   549  C  CG  . MET A 1 80  ? -10.774 -49.645 0.745   1.00 59.52  ? 343  MET A CG  1 
ATOM   550  S  SD  . MET A 1 80  ? -12.055 -50.512 1.761   1.00 56.95  ? 343  MET A SD  1 
ATOM   551  C  CE  . MET A 1 80  ? -11.636 -49.922 3.409   1.00 51.59  ? 343  MET A CE  1 
ATOM   552  N  N   . THR A 1 81  ? -11.629 -45.249 0.965   1.00 83.90  ? 344  THR A N   1 
ATOM   553  C  CA  . THR A 1 81  ? -11.178 -43.834 0.935   1.00 80.55  ? 344  THR A CA  1 
ATOM   554  C  C   . THR A 1 81  ? -11.909 -42.968 1.951   1.00 73.69  ? 344  THR A C   1 
ATOM   555  O  O   . THR A 1 81  ? -13.133 -42.800 1.763   1.00 71.92  ? 344  THR A O   1 
ATOM   556  N  N   . LYS A 1 93  ? -8.898  -27.011 -2.451  0.50 106.56 ? 356  LYS A N   1 
ATOM   557  C  CA  . LYS A 1 93  ? -7.985  -28.036 -3.029  0.50 108.16 ? 356  LYS A CA  1 
ATOM   558  C  C   . LYS A 1 93  ? -6.560  -27.467 -3.073  0.50 113.02 ? 356  LYS A C   1 
ATOM   559  O  O   . LYS A 1 93  ? -6.378  -26.309 -2.638  0.50 110.53 ? 356  LYS A O   1 
ATOM   560  C  CB  . LYS A 1 93  ? -8.473  -28.457 -4.420  0.50 102.39 ? 356  LYS A CB  1 
ATOM   561  C  CG  . LYS A 1 93  ? -7.703  -29.609 -5.050  0.50 97.77  ? 356  LYS A CG  1 
ATOM   562  C  CD  . LYS A 1 93  ? -8.316  -30.110 -6.335  0.50 95.22  ? 356  LYS A CD  1 
ATOM   563  C  CE  . LYS A 1 93  ? -7.495  -31.199 -6.990  0.50 94.00  ? 356  LYS A CE  1 
ATOM   564  N  NZ  . LYS A 1 93  ? -8.187  -31.766 -8.171  0.50 93.55  ? 356  LYS A NZ  1 
ATOM   565  N  N   . GLU A 1 94  ? -5.594  -28.251 -3.573  0.50 114.21 ? 357  GLU A N   1 
ATOM   566  C  CA  . GLU A 1 94  ? -4.149  -27.889 -3.615  0.50 113.84 ? 357  GLU A CA  1 
ATOM   567  C  C   . GLU A 1 94  ? -3.794  -27.288 -4.981  0.50 121.72 ? 357  GLU A C   1 
ATOM   568  O  O   . GLU A 1 94  ? -3.321  -26.134 -5.008  0.50 123.09 ? 357  GLU A O   1 
ATOM   569  C  CB  . GLU A 1 94  ? -3.264  -29.108 -3.347  0.50 105.99 ? 357  GLU A CB  1 
ATOM   570  C  CG  . GLU A 1 94  ? -1.784  -28.830 -3.552  0.50 97.73  ? 357  GLU A CG  1 
ATOM   571  C  CD  . GLU A 1 94  ? -1.414  -28.295 -4.926  0.50 93.88  ? 357  GLU A CD  1 
ATOM   572  O  OE1 . GLU A 1 94  ? -1.449  -29.075 -5.896  0.50 90.67  ? 357  GLU A OE1 1 
ATOM   573  O  OE2 . GLU A 1 94  ? -1.096  -27.095 -5.028  0.50 88.33  ? 357  GLU A OE2 1 
ATOM   574  N  N   . LYS A 1 95  ? -3.999  -28.052 -6.062  0.50 126.62 ? 358  LYS A N   1 
ATOM   575  C  CA  . LYS A 1 95  ? -3.601  -27.679 -7.449  0.50 125.80 ? 358  LYS A CA  1 
ATOM   576  C  C   . LYS A 1 95  ? -4.521  -26.573 -7.981  0.50 125.46 ? 358  LYS A C   1 
ATOM   577  O  O   . LYS A 1 95  ? -4.135  -25.912 -8.971  0.50 119.95 ? 358  LYS A O   1 
ATOM   578  C  CB  . LYS A 1 95  ? -3.640  -28.895 -8.380  0.50 123.39 ? 358  LYS A CB  1 
ATOM   579  C  CG  . LYS A 1 95  ? -3.375  -28.577 -9.846  0.50 118.02 ? 358  LYS A CG  1 
ATOM   580  C  CD  . LYS A 1 95  ? -2.712  -29.699 -10.607 0.50 114.07 ? 358  LYS A CD  1 
ATOM   581  C  CE  . LYS A 1 95  ? -1.881  -29.196 -11.767 0.50 111.96 ? 358  LYS A CE  1 
ATOM   582  N  NZ  . LYS A 1 95  ? -0.959  -30.241 -12.270 0.50 109.36 ? 358  LYS A NZ  1 
ATOM   583  N  N   . VAL A 1 96  ? -5.691  -26.389 -7.359  0.50 122.53 ? 359  VAL A N   1 
ATOM   584  C  CA  . VAL A 1 96  ? -6.647  -25.286 -7.679  0.50 119.33 ? 359  VAL A CA  1 
ATOM   585  C  C   . VAL A 1 96  ? -5.993  -23.950 -7.300  0.50 116.24 ? 359  VAL A C   1 
ATOM   586  O  O   . VAL A 1 96  ? -6.242  -22.955 -8.009  0.50 116.91 ? 359  VAL A O   1 
ATOM   587  C  CB  . VAL A 1 96  ? -8.007  -25.481 -6.980  0.50 118.43 ? 359  VAL A CB  1 
ATOM   588  C  CG1 . VAL A 1 96  ? -7.886  -25.440 -5.464  0.50 119.29 ? 359  VAL A CG1 1 
ATOM   589  C  CG2 . VAL A 1 96  ? -9.036  -24.470 -7.465  0.50 115.98 ? 359  VAL A CG2 1 
ATOM   590  N  N   . ASP A 1 97  ? -5.181  -23.935 -6.235  1.00 111.01 ? 360  ASP A N   1 
ATOM   591  C  CA  . ASP A 1 97  ? -4.360  -22.755 -5.840  1.00 107.31 ? 360  ASP A CA  1 
ATOM   592  C  C   . ASP A 1 97  ? -3.013  -22.865 -6.588  1.00 120.41 ? 360  ASP A C   1 
ATOM   593  O  O   . ASP A 1 97  ? -2.012  -23.266 -5.957  1.00 145.28 ? 360  ASP A O   1 
ATOM   594  C  CB  . ASP A 1 97  ? -4.216  -22.665 -4.310  1.00 101.71 ? 360  ASP A CB  1 
ATOM   595  C  CG  . ASP A 1 97  ? -4.578  -21.337 -3.636  1.00 95.95  ? 360  ASP A CG  1 
ATOM   596  O  OD1 . ASP A 1 97  ? -4.194  -20.254 -4.141  1.00 82.41  ? 360  ASP A OD1 1 
ATOM   597  O  OD2 . ASP A 1 97  ? -5.240  -21.393 -2.576  1.00 88.86  ? 360  ASP A OD2 1 
ATOM   598  N  N   . THR A 1 98  ? -3.007  -22.592 -7.902  1.00 118.85 ? 361  THR A N   1 
ATOM   599  C  CA  . THR A 1 98  ? -1.808  -22.341 -8.761  1.00 117.26 ? 361  THR A CA  1 
ATOM   600  C  C   . THR A 1 98  ? -2.186  -21.211 -9.726  1.00 115.32 ? 361  THR A C   1 
ATOM   601  O  O   . THR A 1 98  ? -3.389  -20.900 -9.767  1.00 111.47 ? 361  THR A O   1 
ATOM   602  C  CB  . THR A 1 98  ? -1.333  -23.607 -9.498  1.00 119.37 ? 361  THR A CB  1 
ATOM   603  O  OG1 . THR A 1 98  ? -2.421  -24.199 -10.213 1.00 111.87 ? 361  THR A OG1 1 
ATOM   604  C  CG2 . THR A 1 98  ? -0.731  -24.643 -8.571  1.00 125.61 ? 361  THR A CG2 1 
ATOM   605  N  N   . ARG A 1 99  ? -1.228  -20.591 -10.432 1.00 126.68 ? 362  ARG A N   1 
ATOM   606  C  CA  . ARG A 1 99  ? -1.504  -19.519 -11.443 1.00 130.65 ? 362  ARG A CA  1 
ATOM   607  C  C   . ARG A 1 99  ? -0.587  -19.689 -12.668 1.00 125.75 ? 362  ARG A C   1 
ATOM   608  O  O   . ARG A 1 99  ? 0.644   -19.845 -12.492 1.00 127.45 ? 362  ARG A O   1 
ATOM   609  C  CB  . ARG A 1 99  ? -1.331  -18.118 -10.839 1.00 134.79 ? 362  ARG A CB  1 
ATOM   610  C  CG  . ARG A 1 99  ? -2.092  -17.026 -11.583 1.00 133.23 ? 362  ARG A CG  1 
ATOM   611  C  CD  . ARG A 1 99  ? -1.391  -15.675 -11.649 1.00 134.88 ? 362  ARG A CD  1 
ATOM   612  N  NE  . ARG A 1 99  ? -0.125  -15.712 -12.383 1.00 145.90 ? 362  ARG A NE  1 
ATOM   613  C  CZ  . ARG A 1 99  ? 0.502   -14.659 -12.919 1.00 131.74 ? 362  ARG A CZ  1 
ATOM   614  N  NH1 . ARG A 1 99  ? -0.014  -13.444 -12.833 1.00 127.13 ? 362  ARG A NH1 1 
ATOM   615  N  NH2 . ARG A 1 99  ? 1.651   -14.831 -13.552 1.00 121.23 ? 362  ARG A NH2 1 
ATOM   616  N  N   . THR A 1 100 ? -1.175  -19.654 -13.871 0.50 122.14 ? 363  THR A N   1 
ATOM   617  C  CA  . THR A 1 100 ? -0.472  -19.784 -15.178 0.50 117.71 ? 363  THR A CA  1 
ATOM   618  C  C   . THR A 1 100 ? -0.116  -18.390 -15.707 0.50 112.24 ? 363  THR A C   1 
ATOM   619  O  O   . THR A 1 100 ? -1.033  -17.556 -15.826 0.50 110.59 ? 363  THR A O   1 
ATOM   620  C  CB  . THR A 1 100 ? -1.320  -20.556 -16.198 0.50 118.03 ? 363  THR A CB  1 
ATOM   621  O  OG1 . THR A 1 100 ? -1.511  -21.889 -15.721 0.50 114.70 ? 363  THR A OG1 1 
ATOM   622  C  CG2 . THR A 1 100 ? -0.686  -20.598 -17.571 0.50 114.99 ? 363  THR A CG2 1 
ATOM   623  N  N   . GLN A 1 101 ? 1.166   -18.161 -16.011 0.50 110.29 ? 364  GLN A N   1 
ATOM   624  C  CA  . GLN A 1 101 ? 1.693   -16.877 -16.548 0.50 106.02 ? 364  GLN A CA  1 
ATOM   625  C  C   . GLN A 1 101 ? 0.995   -16.566 -17.875 0.50 98.52  ? 364  GLN A C   1 
ATOM   626  O  O   . GLN A 1 101 ? 0.502   -17.514 -18.518 0.50 101.09 ? 364  GLN A O   1 
ATOM   627  C  CB  . GLN A 1 101 ? 3.211   -16.952 -16.732 0.50 107.66 ? 364  GLN A CB  1 
ATOM   628  C  CG  . GLN A 1 101 ? 3.828   -15.650 -17.229 0.50 111.25 ? 364  GLN A CG  1 
ATOM   629  C  CD  . GLN A 1 101 ? 5.332   -15.722 -17.345 0.50 112.47 ? 364  GLN A CD  1 
ATOM   630  O  OE1 . GLN A 1 101 ? 5.914   -16.796 -17.484 0.50 109.58 ? 364  GLN A OE1 1 
ATOM   631  N  NE2 . GLN A 1 101 ? 5.976   -14.566 -17.291 0.50 110.02 ? 364  GLN A NE2 1 
ATOM   632  N  N   . GLU A 1 102 ? 0.958   -15.288 -18.262 0.50 89.51  ? 365  GLU A N   1 
ATOM   633  C  CA  . GLU A 1 102 ? 0.337   -14.817 -19.529 0.50 83.42  ? 365  GLU A CA  1 
ATOM   634  C  C   . GLU A 1 102 ? 1.212   -15.247 -20.705 0.50 72.62  ? 365  GLU A C   1 
ATOM   635  O  O   . GLU A 1 102 ? 2.414   -15.001 -20.729 0.50 65.66  ? 365  GLU A O   1 
ATOM   636  C  CB  . GLU A 1 102 ? 0.141   -13.299 -19.505 0.50 86.84  ? 365  GLU A CB  1 
ATOM   637  C  CG  . GLU A 1 102 ? -0.760  -12.792 -20.621 0.50 90.76  ? 365  GLU A CG  1 
ATOM   638  C  CD  . GLU A 1 102 ? -0.979  -11.288 -20.661 0.50 89.76  ? 365  GLU A CD  1 
ATOM   639  O  OE1 . GLU A 1 102 ? -0.118  -10.551 -20.142 0.50 89.19  ? 365  GLU A OE1 1 
ATOM   640  O  OE2 . GLU A 1 102 ? -2.006  -10.858 -21.229 0.50 91.97  ? 365  GLU A OE2 1 
ATOM   641  N  N   . PRO A 1 103 ? 0.634   -15.909 -21.727 0.50 65.60  ? 366  PRO A N   1 
ATOM   642  C  CA  . PRO A 1 103 ? 1.399   -16.297 -22.907 0.50 64.04  ? 366  PRO A CA  1 
ATOM   643  C  C   . PRO A 1 103 ? 2.084   -15.077 -23.538 0.50 61.05  ? 366  PRO A C   1 
ATOM   644  O  O   . PRO A 1 103 ? 1.592   -13.984 -23.356 0.50 59.47  ? 366  PRO A O   1 
ATOM   645  C  CB  . PRO A 1 103 ? 0.340   -16.888 -23.853 0.50 62.14  ? 366  PRO A CB  1 
ATOM   646  C  CG  . PRO A 1 103 ? -0.780  -17.325 -22.935 0.50 63.27  ? 366  PRO A CG  1 
ATOM   647  C  CD  . PRO A 1 103 ? -0.776  -16.317 -21.804 0.50 64.53  ? 366  PRO A CD  1 
ATOM   648  N  N   . LYS A 1 104 ? 3.179   -15.306 -24.267 1.00 60.78  ? 367  LYS A N   1 
ATOM   649  C  CA  . LYS A 1 104 ? 3.873   -14.259 -25.063 1.00 63.45  ? 367  LYS A CA  1 
ATOM   650  C  C   . LYS A 1 104 ? 2.933   -13.789 -26.187 1.00 63.41  ? 367  LYS A C   1 
ATOM   651  O  O   . LYS A 1 104 ? 1.965   -14.498 -26.512 1.00 61.34  ? 367  LYS A O   1 
ATOM   652  C  CB  . LYS A 1 104 ? 5.144   -14.800 -25.742 1.00 67.24  ? 367  LYS A CB  1 
ATOM   653  C  CG  . LYS A 1 104 ? 6.150   -15.569 -24.887 1.00 67.99  ? 367  LYS A CG  1 
ATOM   654  C  CD  . LYS A 1 104 ? 6.363   -14.986 -23.532 1.00 72.07  ? 367  LYS A CD  1 
ATOM   655  C  CE  . LYS A 1 104 ? 7.588   -15.531 -22.837 1.00 76.13  ? 367  LYS A CE  1 
ATOM   656  N  NZ  . LYS A 1 104 ? 7.567   -15.107 -21.417 1.00 81.30  ? 367  LYS A NZ  1 
ATOM   657  N  N   . GLU A 1 105 ? 3.223   -12.622 -26.769 0.50 60.72  ? 368  GLU A N   1 
ATOM   658  C  CA  . GLU A 1 105 ? 2.358   -11.948 -27.774 0.50 60.24  ? 368  GLU A CA  1 
ATOM   659  C  C   . GLU A 1 105 ? 2.270   -12.815 -29.036 0.50 54.99  ? 368  GLU A C   1 
ATOM   660  O  O   . GLU A 1 105 ? 1.206   -12.812 -29.679 0.50 54.05  ? 368  GLU A O   1 
ATOM   661  C  CB  . GLU A 1 105 ? 2.890   -10.543 -28.078 0.50 64.34  ? 368  GLU A CB  1 
ATOM   662  C  CG  . GLU A 1 105 ? 3.126   -9.695  -26.836 0.50 64.01  ? 368  GLU A CG  1 
ATOM   663  C  CD  . GLU A 1 105 ? 1.945   -9.592  -25.884 0.50 65.01  ? 368  GLU A CD  1 
ATOM   664  O  OE1 . GLU A 1 105 ? 0.811   -9.383  -26.363 0.50 67.31  ? 368  GLU A OE1 1 
ATOM   665  O  OE2 . GLU A 1 105 ? 2.161   -9.721  -24.664 0.50 64.66  ? 368  GLU A OE2 1 
ATOM   666  N  N   . GLY A 1 106 ? 3.341   -13.537 -29.376 0.50 51.46  ? 369  GLY A N   1 
ATOM   667  C  CA  . GLY A 1 106 ? 3.365   -14.442 -30.543 0.50 50.68  ? 369  GLY A CA  1 
ATOM   668  C  C   . GLY A 1 106 ? 2.410   -15.615 -30.351 0.50 51.62  ? 369  GLY A C   1 
ATOM   669  O  O   . GLY A 1 106 ? 1.698   -15.959 -31.318 0.50 49.78  ? 369  GLY A O   1 
ATOM   670  N  N   . THR A 1 107 ? 2.389   -16.193 -29.143 1.00 47.81  ? 370  THR A N   1 
ATOM   671  C  CA  . THR A 1 107 ? 1.478   -17.296 -28.744 1.00 52.30  ? 370  THR A CA  1 
ATOM   672  C  C   . THR A 1 107 ? 0.011   -16.831 -28.834 1.00 54.08  ? 370  THR A C   1 
ATOM   673  O  O   . THR A 1 107 ? -0.763  -17.475 -29.597 1.00 52.47  ? 370  THR A O   1 
ATOM   674  C  CB  . THR A 1 107 ? 1.869   -17.812 -27.353 1.00 56.05  ? 370  THR A CB  1 
ATOM   675  O  OG1 . THR A 1 107 ? 3.289   -17.980 -27.335 1.00 52.69  ? 370  THR A OG1 1 
ATOM   676  C  CG2 . THR A 1 107 ? 1.195   -19.120 -26.995 1.00 54.44  ? 370  THR A CG2 1 
ATOM   677  N  N   . LYS A 1 108 ? -0.334  -15.734 -28.144 1.00 54.97  ? 371  LYS A N   1 
ATOM   678  C  CA  . LYS A 1 108 ? -1.664  -15.037 -28.192 1.00 54.86  ? 371  LYS A CA  1 
ATOM   679  C  C   . LYS A 1 108 ? -2.152  -14.797 -29.634 1.00 48.27  ? 371  LYS A C   1 
ATOM   680  O  O   . LYS A 1 108 ? -3.311  -15.098 -29.917 1.00 47.33  ? 371  LYS A O   1 
ATOM   681  C  CB  . LYS A 1 108 ? -1.614  -13.733 -27.386 1.00 60.37  ? 371  LYS A CB  1 
ATOM   682  C  CG  . LYS A 1 108 ? -1.270  -13.923 -25.911 1.00 59.93  ? 371  LYS A CG  1 
ATOM   683  C  CD  . LYS A 1 108 ? -1.696  -12.806 -24.997 1.00 58.87  ? 371  LYS A CD  1 
ATOM   684  C  CE  . LYS A 1 108 ? -0.749  -11.624 -24.990 1.00 75.13  ? 371  LYS A CE  1 
ATOM   685  N  NZ  . LYS A 1 108 ? -0.750  -10.905 -23.687 1.00 78.87  ? 371  LYS A NZ  1 
ATOM   686  N  N   . LYS A 1 109 ? -1.311  -14.336 -30.541 1.00 45.16  ? 372  LYS A N   1 
ATOM   687  C  CA  . LYS A 1 109 ? -1.698  -14.167 -31.966 1.00 50.74  ? 372  LYS A CA  1 
ATOM   688  C  C   . LYS A 1 109 ? -2.106  -15.514 -32.593 1.00 53.53  ? 372  LYS A C   1 
ATOM   689  O  O   . LYS A 1 109 ? -3.164  -15.529 -33.295 1.00 48.76  ? 372  LYS A O   1 
ATOM   690  C  CB  . LYS A 1 109 ? -0.560  -13.534 -32.772 1.00 57.48  ? 372  LYS A CB  1 
ATOM   691  C  CG  . LYS A 1 109 ? -0.970  -12.924 -34.114 1.00 74.20  ? 372  LYS A CG  1 
ATOM   692  C  CD  . LYS A 1 109 ? -2.103  -11.880 -34.027 1.00 82.97  ? 372  LYS A CD  1 
ATOM   693  C  CE  . LYS A 1 109 ? -1.885  -10.832 -32.951 1.00 89.37  ? 372  LYS A CE  1 
ATOM   694  N  NZ  . LYS A 1 109 ? -2.840  -9.702  -33.067 1.00 89.32  ? 372  LYS A NZ  1 
ATOM   695  N  N   . LEU A 1 110 ? -1.253  -16.552 -32.418 1.00 53.92  ? 373  LEU A N   1 
ATOM   696  C  CA  . LEU A 1 110 ? -1.418  -17.946 -32.937 1.00 49.31  ? 373  LEU A CA  1 
ATOM   697  C  C   . LEU A 1 110 ? -2.779  -18.474 -32.454 1.00 38.76  ? 373  LEU A C   1 
ATOM   698  O  O   . LEU A 1 110 ? -3.525  -19.001 -33.280 1.00 37.50  ? 373  LEU A O   1 
ATOM   699  C  CB  . LEU A 1 110 ? -0.278  -18.859 -32.457 1.00 47.47  ? 373  LEU A CB  1 
ATOM   700  C  CG  . LEU A 1 110 ? 1.083   -18.701 -33.166 1.00 50.39  ? 373  LEU A CG  1 
ATOM   701  C  CD1 . LEU A 1 110 ? 2.197   -19.383 -32.378 1.00 42.74  ? 373  LEU A CD1 1 
ATOM   702  C  CD2 . LEU A 1 110 ? 1.041   -19.221 -34.611 1.00 53.70  ? 373  LEU A CD2 1 
ATOM   703  N  N   . MET A 1 111 ? -3.056  -18.306 -31.172 1.00 34.17  ? 374  MET A N   1 
ATOM   704  C  CA  . MET A 1 111 ? -4.293  -18.774 -30.493 1.00 41.25  ? 374  MET A CA  1 
ATOM   705  C  C   . MET A 1 111 ? -5.518  -18.031 -31.063 1.00 45.61  ? 374  MET A C   1 
ATOM   706  O  O   . MET A 1 111 ? -6.511  -18.739 -31.406 1.00 41.41  ? 374  MET A O   1 
ATOM   707  C  CB  . MET A 1 111 ? -4.210  -18.612 -28.967 1.00 36.59  ? 374  MET A CB  1 
ATOM   708  C  CG  . MET A 1 111 ? -3.253  -19.640 -28.332 1.00 39.09  ? 374  MET A CG  1 
ATOM   709  S  SD  . MET A 1 111 ? -3.400  -19.829 -26.546 1.00 47.53  ? 374  MET A SD  1 
ATOM   710  C  CE  . MET A 1 111 ? -3.100  -18.156 -26.002 1.00 45.83  ? 374  MET A CE  1 
ATOM   711  N  N   . LYS A 1 112 ? -5.445  -16.699 -31.218 1.00 44.41  ? 375  LYS A N   1 
ATOM   712  C  CA  . LYS A 1 112 ? -6.583  -15.852 -31.689 1.00 49.79  ? 375  LYS A CA  1 
ATOM   713  C  C   . LYS A 1 112 ? -6.855  -16.202 -33.160 1.00 46.47  ? 375  LYS A C   1 
ATOM   714  O  O   . LYS A 1 112 ? -7.994  -16.404 -33.494 1.00 44.61  ? 375  LYS A O   1 
ATOM   715  C  CB  . LYS A 1 112 ? -6.308  -14.347 -31.531 1.00 59.83  ? 375  LYS A CB  1 
ATOM   716  C  CG  . LYS A 1 112 ? -7.433  -13.491 -30.935 1.00 69.02  ? 375  LYS A CG  1 
ATOM   717  C  CD  . LYS A 1 112 ? -7.235  -13.191 -29.432 1.00 76.63  ? 375  LYS A CD  1 
ATOM   718  C  CE  . LYS A 1 112 ? -8.478  -12.767 -28.663 1.00 79.64  ? 375  LYS A CE  1 
ATOM   719  N  NZ  . LYS A 1 112 ? -8.267  -12.849 -27.191 1.00 74.07  ? 375  LYS A NZ  1 
ATOM   720  N  N   . ILE A 1 113 ? -5.838  -16.315 -34.004 1.00 44.12  ? 376  ILE A N   1 
ATOM   721  C  CA  . ILE A 1 113 ? -6.045  -16.658 -35.436 1.00 44.85  ? 376  ILE A CA  1 
ATOM   722  C  C   . ILE A 1 113 ? -6.666  -18.054 -35.542 1.00 50.13  ? 376  ILE A C   1 
ATOM   723  O  O   . ILE A 1 113 ? -7.567  -18.249 -36.432 1.00 43.04  ? 376  ILE A O   1 
ATOM   724  C  CB  . ILE A 1 113 ? -4.737  -16.588 -36.237 1.00 45.35  ? 376  ILE A CB  1 
ATOM   725  C  CG1 . ILE A 1 113 ? -4.228  -15.154 -36.392 1.00 58.33  ? 376  ILE A CG1 1 
ATOM   726  C  CG2 . ILE A 1 113 ? -4.877  -17.245 -37.605 1.00 42.95  ? 376  ILE A CG2 1 
ATOM   727  C  CD1 . ILE A 1 113 ? -2.780  -15.074 -36.852 1.00 59.06  ? 376  ILE A CD1 1 
ATOM   728  N  N   . THR A 1 114 ? -6.158  -19.022 -34.757 1.00 45.83  ? 377  THR A N   1 
ATOM   729  C  CA  . THR A 1 114 ? -6.591  -20.446 -34.847 1.00 40.20  ? 377  THR A CA  1 
ATOM   730  C  C   . THR A 1 114 ? -8.027  -20.568 -34.333 1.00 33.86  ? 377  THR A C   1 
ATOM   731  O  O   . THR A 1 114 ? -8.857  -21.240 -35.024 1.00 33.31  ? 377  THR A O   1 
ATOM   732  C  CB  . THR A 1 114 ? -5.648  -21.391 -34.098 1.00 37.84  ? 377  THR A CB  1 
ATOM   733  O  OG1 . THR A 1 114 ? -4.316  -21.080 -34.486 1.00 37.13  ? 377  THR A OG1 1 
ATOM   734  C  CG2 . THR A 1 114 ? -5.920  -22.828 -34.447 1.00 35.51  ? 377  THR A CG2 1 
ATOM   735  N  N   . ALA A 1 115 ? -8.324  -19.920 -33.198 1.00 36.01  ? 378  ALA A N   1 
ATOM   736  C  CA  . ALA A 1 115 ? -9.667  -19.970 -32.567 1.00 38.77  ? 378  ALA A CA  1 
ATOM   737  C  C   . ALA A 1 115 ? -10.716 -19.354 -33.527 1.00 43.08  ? 378  ALA A C   1 
ATOM   738  O  O   . ALA A 1 115 ? -11.783 -20.019 -33.821 1.00 42.01  ? 378  ALA A O   1 
ATOM   739  C  CB  . ALA A 1 115 ? -9.638  -19.298 -31.223 1.00 37.81  ? 378  ALA A CB  1 
ATOM   740  N  N   . GLU A 1 116 ? -10.404 -18.184 -34.095 1.00 41.35  ? 379  GLU A N   1 
ATOM   741  C  CA  . GLU A 1 116 ? -11.281 -17.491 -35.083 1.00 45.38  ? 379  GLU A CA  1 
ATOM   742  C  C   . GLU A 1 116 ? -11.564 -18.484 -36.218 1.00 44.31  ? 379  GLU A C   1 
ATOM   743  O  O   . GLU A 1 116 ? -12.736 -18.743 -36.495 1.00 39.91  ? 379  GLU A O   1 
ATOM   744  C  CB  . GLU A 1 116 ? -10.680 -16.149 -35.513 1.00 43.82  ? 379  GLU A CB  1 
ATOM   745  C  CG  . GLU A 1 116 ? -11.359 -15.525 -36.724 1.00 55.49  ? 379  GLU A CG  1 
ATOM   746  C  CD  . GLU A 1 116 ? -10.783 -14.192 -37.217 1.00 67.07  ? 379  GLU A CD  1 
ATOM   747  O  OE1 . GLU A 1 116 ? -9.503  -14.055 -37.270 1.00 66.33  ? 379  GLU A OE1 1 
ATOM   748  O  OE2 . GLU A 1 116 ? -11.606 -13.287 -37.546 1.00 73.19  ? 379  GLU A OE2 1 
ATOM   749  N  N   . TRP A 1 117 ? -10.534 -19.081 -36.816 1.00 37.41  ? 380  TRP A N   1 
ATOM   750  C  CA  . TRP A 1 117 ? -10.700 -20.037 -37.934 1.00 36.01  ? 380  TRP A CA  1 
ATOM   751  C  C   . TRP A 1 117 ? -11.485 -21.291 -37.460 1.00 44.45  ? 380  TRP A C   1 
ATOM   752  O  O   . TRP A 1 117 ? -12.231 -21.896 -38.278 1.00 37.50  ? 380  TRP A O   1 
ATOM   753  C  CB  . TRP A 1 117 ? -9.324  -20.385 -38.499 1.00 36.97  ? 380  TRP A CB  1 
ATOM   754  C  CG  . TRP A 1 117 ? -9.377  -21.471 -39.500 1.00 34.95  ? 380  TRP A CG  1 
ATOM   755  C  CD1 . TRP A 1 117 ? -9.532  -21.320 -40.829 1.00 37.40  ? 380  TRP A CD1 1 
ATOM   756  C  CD2 . TRP A 1 117 ? -9.355  -22.883 -39.255 1.00 42.08  ? 380  TRP A CD2 1 
ATOM   757  N  NE1 . TRP A 1 117 ? -9.520  -22.535 -41.445 1.00 44.41  ? 380  TRP A NE1 1 
ATOM   758  C  CE2 . TRP A 1 117 ? -9.437  -23.518 -40.501 1.00 41.28  ? 380  TRP A CE2 1 
ATOM   759  C  CE3 . TRP A 1 117 ? -9.218  -23.677 -38.120 1.00 41.93  ? 380  TRP A CE3 1 
ATOM   760  C  CZ2 . TRP A 1 117 ? -9.438  -24.903 -40.643 1.00 45.03  ? 380  TRP A CZ2 1 
ATOM   761  C  CZ3 . TRP A 1 117 ? -9.160  -25.038 -38.263 1.00 36.59  ? 380  TRP A CZ3 1 
ATOM   762  C  CH2 . TRP A 1 117 ? -9.313  -25.646 -39.496 1.00 38.66  ? 380  TRP A CH2 1 
ATOM   763  N  N   . LEU A 1 118 ? -11.338 -21.724 -36.204 1.00 40.76  ? 381  LEU A N   1 
ATOM   764  C  CA  . LEU A 1 118 ? -11.923 -23.024 -35.780 1.00 38.73  ? 381  LEU A CA  1 
ATOM   765  C  C   . LEU A 1 118 ? -13.433 -22.840 -35.539 1.00 37.61  ? 381  LEU A C   1 
ATOM   766  O  O   . LEU A 1 118 ? -14.210 -23.675 -36.035 1.00 34.82  ? 381  LEU A O   1 
ATOM   767  C  CB  . LEU A 1 118 ? -11.194 -23.541 -34.539 1.00 38.81  ? 381  LEU A CB  1 
ATOM   768  C  CG  . LEU A 1 118 ? -11.605 -24.948 -34.111 1.00 40.74  ? 381  LEU A CG  1 
ATOM   769  C  CD1 . LEU A 1 118 ? -11.479 -25.944 -35.269 1.00 40.39  ? 381  LEU A CD1 1 
ATOM   770  C  CD2 . LEU A 1 118 ? -10.797 -25.381 -32.904 1.00 43.82  ? 381  LEU A CD2 1 
ATOM   771  N  N   . TRP A 1 119 ? -13.839 -21.780 -34.826 1.00 35.87  ? 382  TRP A N   1 
ATOM   772  C  CA  . TRP A 1 119 ? -15.269 -21.391 -34.684 1.00 40.64  ? 382  TRP A CA  1 
ATOM   773  C  C   . TRP A 1 119 ? -15.958 -21.257 -36.063 1.00 43.76  ? 382  TRP A C   1 
ATOM   774  O  O   . TRP A 1 119 ? -17.070 -21.858 -36.249 1.00 45.99  ? 382  TRP A O   1 
ATOM   775  C  CB  . TRP A 1 119 ? -15.380 -20.131 -33.839 1.00 36.67  ? 382  TRP A CB  1 
ATOM   776  C  CG  . TRP A 1 119 ? -15.229 -20.366 -32.370 1.00 32.19  ? 382  TRP A CG  1 
ATOM   777  C  CD1 . TRP A 1 119 ? -14.479 -19.637 -31.500 1.00 37.32  ? 382  TRP A CD1 1 
ATOM   778  C  CD2 . TRP A 1 119 ? -15.899 -21.363 -31.576 1.00 34.99  ? 382  TRP A CD2 1 
ATOM   779  N  NE1 . TRP A 1 119 ? -14.670 -20.076 -30.217 1.00 35.47  ? 382  TRP A NE1 1 
ATOM   780  C  CE2 . TRP A 1 119 ? -15.522 -21.149 -30.240 1.00 34.83  ? 382  TRP A CE2 1 
ATOM   781  C  CE3 . TRP A 1 119 ? -16.864 -22.344 -31.842 1.00 37.04  ? 382  TRP A CE3 1 
ATOM   782  C  CZ2 . TRP A 1 119 ? -15.989 -21.952 -29.207 1.00 36.38  ? 382  TRP A CZ2 1 
ATOM   783  C  CZ3 . TRP A 1 119 ? -17.340 -23.131 -30.815 1.00 35.51  ? 382  TRP A CZ3 1 
ATOM   784  C  CH2 . TRP A 1 119 ? -16.902 -22.932 -29.513 1.00 34.26  ? 382  TRP A CH2 1 
ATOM   785  N  N   . LYS A 1 120 ? -15.317 -20.615 -37.047 1.00 39.74  ? 383  LYS A N   1 
ATOM   786  C  CA  . LYS A 1 120 ? -15.875 -20.552 -38.424 1.00 44.31  ? 383  LYS A CA  1 
ATOM   787  C  C   . LYS A 1 120 ? -16.065 -21.955 -38.967 1.00 42.79  ? 383  LYS A C   1 
ATOM   788  O  O   . LYS A 1 120 ? -17.124 -22.188 -39.551 1.00 46.18  ? 383  LYS A O   1 
ATOM   789  C  CB  . LYS A 1 120 ? -15.015 -19.809 -39.453 1.00 57.64  ? 383  LYS A CB  1 
ATOM   790  C  CG  . LYS A 1 120 ? -15.177 -18.296 -39.467 1.00 70.19  ? 383  LYS A CG  1 
ATOM   791  C  CD  . LYS A 1 120 ? -14.827 -17.665 -40.800 1.00 84.11  ? 383  LYS A CD  1 
ATOM   792  C  CE  . LYS A 1 120 ? -14.675 -16.161 -40.704 1.00 94.44  ? 383  LYS A CE  1 
ATOM   793  N  NZ  . LYS A 1 120 ? -13.645 -15.781 -39.703 1.00 94.52  ? 383  LYS A NZ  1 
ATOM   794  N  N   . GLU A 1 121 ? -15.074 -22.847 -38.872 1.00 40.09  ? 384  GLU A N   1 
ATOM   795  C  CA  . GLU A 1 121 ? -15.231 -24.204 -39.455 1.00 40.08  ? 384  GLU A CA  1 
ATOM   796  C  C   . GLU A 1 121 ? -16.359 -24.960 -38.751 1.00 37.92  ? 384  GLU A C   1 
ATOM   797  O  O   . GLU A 1 121 ? -17.075 -25.712 -39.432 1.00 40.43  ? 384  GLU A O   1 
ATOM   798  C  CB  . GLU A 1 121 ? -14.001 -25.079 -39.262 1.00 45.40  ? 384  GLU A CB  1 
ATOM   799  C  CG  . GLU A 1 121 ? -12.872 -24.685 -40.145 1.00 47.31  ? 384  GLU A CG  1 
ATOM   800  C  CD  . GLU A 1 121 ? -13.161 -24.788 -41.622 1.00 49.39  ? 384  GLU A CD  1 
ATOM   801  O  OE1 . GLU A 1 121 ? -13.574 -25.873 -42.108 1.00 47.46  ? 384  GLU A OE1 1 
ATOM   802  O  OE2 . GLU A 1 121 ? -12.927 -23.782 -42.277 1.00 50.82  ? 384  GLU A OE2 1 
ATOM   803  N  N   . LEU A 1 122 ? -16.464 -24.839 -37.423 1.00 38.63  ? 385  LEU A N   1 
ATOM   804  C  CA  . LEU A 1 122 ? -17.453 -25.626 -36.636 1.00 33.72  ? 385  LEU A CA  1 
ATOM   805  C  C   . LEU A 1 122 ? -18.848 -25.071 -36.975 1.00 38.38  ? 385  LEU A C   1 
ATOM   806  O  O   . LEU A 1 122 ? -19.830 -25.837 -36.906 1.00 35.97  ? 385  LEU A O   1 
ATOM   807  C  CB  . LEU A 1 122 ? -17.147 -25.503 -35.140 1.00 32.90  ? 385  LEU A CB  1 
ATOM   808  C  CG  . LEU A 1 122 ? -15.856 -26.167 -34.639 1.00 36.08  ? 385  LEU A CG  1 
ATOM   809  C  CD1 . LEU A 1 122 ? -15.697 -25.985 -33.148 1.00 31.38  ? 385  LEU A CD1 1 
ATOM   810  C  CD2 . LEU A 1 122 ? -15.851 -27.636 -34.997 1.00 39.62  ? 385  LEU A CD2 1 
ATOM   811  N  N   . GLY A 1 123 ? -18.904 -23.801 -37.374 1.00 38.38  ? 386  GLY A N   1 
ATOM   812  C  CA  . GLY A 1 123 ? -20.145 -23.055 -37.659 1.00 43.28  ? 386  GLY A CA  1 
ATOM   813  C  C   . GLY A 1 123 ? -20.642 -23.249 -39.076 1.00 44.70  ? 386  GLY A C   1 
ATOM   814  O  O   . GLY A 1 123 ? -21.797 -22.895 -39.321 1.00 47.37  ? 386  GLY A O   1 
ATOM   815  N  N   . LYS A 1 124 ? -19.846 -23.814 -39.983 1.00 42.55  ? 387  LYS A N   1 
ATOM   816  C  CA  . LYS A 1 124 ? -20.216 -23.832 -41.418 1.00 45.06  ? 387  LYS A CA  1 
ATOM   817  C  C   . LYS A 1 124 ? -21.540 -24.568 -41.648 1.00 48.63  ? 387  LYS A C   1 
ATOM   818  O  O   . LYS A 1 124 ? -22.315 -24.130 -42.480 1.00 52.63  ? 387  LYS A O   1 
ATOM   819  C  CB  . LYS A 1 124 ? -19.121 -24.434 -42.292 1.00 45.83  ? 387  LYS A CB  1 
ATOM   820  C  CG  . LYS A 1 124 ? -17.955 -23.480 -42.559 1.00 51.00  ? 387  LYS A CG  1 
ATOM   821  C  CD  . LYS A 1 124 ? -17.027 -23.993 -43.644 1.00 54.90  ? 387  LYS A CD  1 
ATOM   822  C  CE  . LYS A 1 124 ? -15.719 -23.238 -43.742 1.00 57.59  ? 387  LYS A CE  1 
ATOM   823  N  NZ  . LYS A 1 124 ? -14.790 -24.021 -44.594 1.00 63.80  ? 387  LYS A NZ  1 
ATOM   824  N  N   . LYS A 1 125 ? -21.772 -25.671 -40.930 0.50 48.60  ? 388  LYS A N   1 
ATOM   825  C  CA  . LYS A 1 125 ? -22.975 -26.529 -41.100 0.50 48.43  ? 388  LYS A CA  1 
ATOM   826  C  C   . LYS A 1 125 ? -23.781 -26.597 -39.797 0.50 46.32  ? 388  LYS A C   1 
ATOM   827  O  O   . LYS A 1 125 ? -24.486 -27.591 -39.611 0.50 49.00  ? 388  LYS A O   1 
ATOM   828  C  CB  . LYS A 1 125 ? -22.562 -27.937 -41.527 0.50 50.49  ? 388  LYS A CB  1 
ATOM   829  C  CG  . LYS A 1 125 ? -21.608 -27.998 -42.708 0.50 55.38  ? 388  LYS A CG  1 
ATOM   830  C  CD  . LYS A 1 125 ? -21.195 -29.417 -43.050 0.50 61.01  ? 388  LYS A CD  1 
ATOM   831  C  CE  . LYS A 1 125 ? -20.548 -30.133 -41.882 0.50 65.93  ? 388  LYS A CE  1 
ATOM   832  N  NZ  . LYS A 1 125 ? -20.769 -31.601 -41.936 0.50 70.09  ? 388  LYS A NZ  1 
ATOM   833  N  N   . LYS A 1 126 ? -23.685 -25.583 -38.935 1.00 44.95  ? 389  LYS A N   1 
ATOM   834  C  CA  . LYS A 1 126 ? -24.418 -25.557 -37.655 1.00 42.46  ? 389  LYS A CA  1 
ATOM   835  C  C   . LYS A 1 126 ? -24.924 -24.139 -37.429 1.00 45.81  ? 389  LYS A C   1 
ATOM   836  O  O   . LYS A 1 126 ? -24.266 -23.208 -37.868 1.00 49.49  ? 389  LYS A O   1 
ATOM   837  C  CB  . LYS A 1 126 ? -23.562 -25.950 -36.451 1.00 44.50  ? 389  LYS A CB  1 
ATOM   838  C  CG  . LYS A 1 126 ? -22.994 -27.357 -36.462 1.00 41.84  ? 389  LYS A CG  1 
ATOM   839  C  CD  . LYS A 1 126 ? -24.013 -28.366 -36.088 1.00 44.91  ? 389  LYS A CD  1 
ATOM   840  C  CE  . LYS A 1 126 ? -23.393 -29.715 -35.867 1.00 46.60  ? 389  LYS A CE  1 
ATOM   841  N  NZ  . LYS A 1 126 ? -24.335 -30.788 -36.222 1.00 42.16  ? 389  LYS A NZ  1 
ATOM   842  N  N   . THR A 1 127 ? -26.068 -24.013 -36.741 1.00 46.55  ? 390  THR A N   1 
ATOM   843  C  CA  . THR A 1 127 ? -26.673 -22.723 -36.346 1.00 46.61  ? 390  THR A CA  1 
ATOM   844  C  C   . THR A 1 127 ? -26.718 -22.632 -34.831 1.00 35.73  ? 390  THR A C   1 
ATOM   845  O  O   . THR A 1 127 ? -27.487 -23.313 -34.181 1.00 43.92  ? 390  THR A O   1 
ATOM   846  C  CB  . THR A 1 127 ? -28.096 -22.587 -36.905 1.00 53.09  ? 390  THR A CB  1 
ATOM   847  O  OG1 . THR A 1 127 ? -28.006 -22.708 -38.324 1.00 46.80  ? 390  THR A OG1 1 
ATOM   848  C  CG2 . THR A 1 127 ? -28.742 -21.280 -36.493 1.00 51.65  ? 390  THR A CG2 1 
ATOM   849  N  N   . PRO A 1 128 ? -25.982 -21.705 -34.210 1.00 36.47  ? 391  PRO A N   1 
ATOM   850  C  CA  . PRO A 1 128 ? -26.167 -21.481 -32.779 1.00 37.44  ? 391  PRO A CA  1 
ATOM   851  C  C   . PRO A 1 128 ? -27.654 -21.166 -32.494 1.00 44.34  ? 391  PRO A C   1 
ATOM   852  O  O   . PRO A 1 128 ? -28.366 -20.563 -33.326 1.00 44.30  ? 391  PRO A O   1 
ATOM   853  C  CB  . PRO A 1 128 ? -25.253 -20.285 -32.469 1.00 35.08  ? 391  PRO A CB  1 
ATOM   854  C  CG  . PRO A 1 128 ? -24.297 -20.213 -33.635 1.00 35.92  ? 391  PRO A CG  1 
ATOM   855  C  CD  . PRO A 1 128 ? -25.002 -20.809 -34.836 1.00 32.33  ? 391  PRO A CD  1 
ATOM   856  N  N   . ARG A 1 129 ? -28.140 -21.575 -31.338 1.00 45.34  ? 392  ARG A N   1 
ATOM   857  C  CA  . ARG A 1 129 ? -29.556 -21.320 -30.983 1.00 44.66  ? 392  ARG A CA  1 
ATOM   858  C  C   . ARG A 1 129 ? -29.687 -21.473 -29.482 1.00 51.88  ? 392  ARG A C   1 
ATOM   859  O  O   . ARG A 1 129 ? -28.792 -22.145 -28.893 1.00 43.19  ? 392  ARG A O   1 
ATOM   860  C  CB  . ARG A 1 129 ? -30.496 -22.210 -31.796 1.00 44.91  ? 392  ARG A CB  1 
ATOM   861  C  CG  . ARG A 1 129 ? -30.179 -23.694 -31.786 1.00 45.96  ? 392  ARG A CG  1 
ATOM   862  C  CD  . ARG A 1 129 ? -30.975 -24.312 -30.701 1.00 43.51  ? 392  ARG A CD  1 
ATOM   863  N  NE  . ARG A 1 129 ? -30.755 -25.728 -30.545 1.00 43.54  ? 392  ARG A NE  1 
ATOM   864  C  CZ  . ARG A 1 129 ? -31.376 -26.434 -29.620 1.00 44.19  ? 392  ARG A CZ  1 
ATOM   865  N  NH1 . ARG A 1 129 ? -32.258 -25.834 -28.843 1.00 43.79  ? 392  ARG A NH1 1 
ATOM   866  N  NH2 . ARG A 1 129 ? -31.147 -27.722 -29.484 1.00 41.12  ? 392  ARG A NH2 1 
ATOM   867  N  N   . MET A 1 130 ? -30.697 -20.818 -28.890 1.00 46.45  ? 393  MET A N   1 
ATOM   868  C  CA  . MET A 1 130 ? -30.960 -20.943 -27.439 1.00 48.09  ? 393  MET A CA  1 
ATOM   869  C  C   . MET A 1 130 ? -31.572 -22.314 -27.159 1.00 43.62  ? 393  MET A C   1 
ATOM   870  O  O   . MET A 1 130 ? -32.312 -22.834 -27.980 1.00 45.65  ? 393  MET A O   1 
ATOM   871  C  CB  . MET A 1 130 ? -31.892 -19.856 -26.924 1.00 56.12  ? 393  MET A CB  1 
ATOM   872  C  CG  . MET A 1 130 ? -31.345 -18.480 -27.160 1.00 68.82  ? 393  MET A CG  1 
ATOM   873  S  SD  . MET A 1 130 ? -32.214 -17.203 -26.212 1.00 79.61  ? 393  MET A SD  1 
ATOM   874  C  CE  . MET A 1 130 ? -33.891 -17.850 -26.239 1.00 85.32  ? 393  MET A CE  1 
ATOM   875  N  N   . CYS A 1 131 ? -31.228 -22.921 -26.040 1.00 41.73  ? 394  CYS A N   1 
ATOM   876  C  CA  . CYS A 1 131 ? -31.959 -24.115 -25.568 1.00 44.90  ? 394  CYS A CA  1 
ATOM   877  C  C   . CYS A 1 131 ? -33.108 -23.611 -24.669 1.00 49.67  ? 394  CYS A C   1 
ATOM   878  O  O   . CYS A 1 131 ? -33.054 -22.427 -24.201 1.00 56.53  ? 394  CYS A O   1 
ATOM   879  C  CB  . CYS A 1 131 ? -31.001 -25.100 -24.898 1.00 46.81  ? 394  CYS A CB  1 
ATOM   880  S  SG  . CYS A 1 131 ? -29.790 -25.840 -26.035 1.00 50.62  ? 394  CYS A SG  1 
ATOM   881  N  N   . THR A 1 132 ? -34.129 -24.435 -24.456 1.00 49.13  ? 395  THR A N   1 
ATOM   882  C  CA  . THR A 1 132 ? -35.443 -23.988 -23.901 1.00 58.27  ? 395  THR A CA  1 
ATOM   883  C  C   . THR A 1 132 ? -35.718 -24.644 -22.542 1.00 54.68  ? 395  THR A C   1 
ATOM   884  O  O   . THR A 1 132 ? -35.146 -25.708 -22.267 1.00 53.63  ? 395  THR A O   1 
ATOM   885  C  CB  . THR A 1 132 ? -36.555 -24.265 -24.922 1.00 57.63  ? 395  THR A CB  1 
ATOM   886  O  OG1 . THR A 1 132 ? -36.639 -25.676 -25.149 1.00 53.91  ? 395  THR A OG1 1 
ATOM   887  C  CG2 . THR A 1 132 ? -36.320 -23.550 -26.240 1.00 55.74  ? 395  THR A CG2 1 
ATOM   888  N  N   . ARG A 1 133 ? -36.576 -24.016 -21.732 1.00 64.45  ? 396  ARG A N   1 
ATOM   889  C  CA  . ARG A 1 133 ? -37.126 -24.573 -20.460 1.00 65.71  ? 396  ARG A CA  1 
ATOM   890  C  C   . ARG A 1 133 ? -37.631 -25.995 -20.711 1.00 64.70  ? 396  ARG A C   1 
ATOM   891  O  O   . ARG A 1 133 ? -37.292 -26.922 -19.940 1.00 68.04  ? 396  ARG A O   1 
ATOM   892  C  CB  . ARG A 1 133 ? -38.239 -23.672 -19.913 1.00 75.33  ? 396  ARG A CB  1 
ATOM   893  C  CG  . ARG A 1 133 ? -37.752 -22.260 -19.629 1.00 86.83  ? 396  ARG A CG  1 
ATOM   894  C  CD  . ARG A 1 133 ? -38.678 -21.333 -18.868 1.00 96.38  ? 396  ARG A CD  1 
ATOM   895  N  NE  . ARG A 1 133 ? -37.984 -20.076 -18.584 1.00 95.49  ? 396  ARG A NE  1 
ATOM   896  C  CZ  . ARG A 1 133 ? -38.465 -19.068 -17.857 1.00 98.47  ? 396  ARG A CZ  1 
ATOM   897  N  NH1 . ARG A 1 133 ? -39.682 -19.128 -17.339 1.00 100.12 ? 396  ARG A NH1 1 
ATOM   898  N  NH2 . ARG A 1 133 ? -37.724 -17.988 -17.674 1.00 89.15  ? 396  ARG A NH2 1 
ATOM   899  N  N   . GLU A 1 134 ? -38.399 -26.161 -21.791 0.50 65.61  ? 397  GLU A N   1 
ATOM   900  C  CA  . GLU A 1 134 ? -39.042 -27.434 -22.205 0.50 66.50  ? 397  GLU A CA  1 
ATOM   901  C  C   . GLU A 1 134 ? -37.968 -28.496 -22.455 0.50 65.27  ? 397  GLU A C   1 
ATOM   902  O  O   . GLU A 1 134 ? -38.232 -29.670 -22.157 0.50 70.55  ? 397  GLU A O   1 
ATOM   903  C  CB  . GLU A 1 134 ? -39.899 -27.193 -23.449 0.50 72.56  ? 397  GLU A CB  1 
ATOM   904  C  CG  . GLU A 1 134 ? -41.177 -26.414 -23.172 0.50 76.55  ? 397  GLU A CG  1 
ATOM   905  C  CD  . GLU A 1 134 ? -41.017 -25.006 -22.611 0.50 77.79  ? 397  GLU A CD  1 
ATOM   906  O  OE1 . GLU A 1 134 ? -40.105 -24.277 -23.066 0.50 75.21  ? 397  GLU A OE1 1 
ATOM   907  O  OE2 . GLU A 1 134 ? -41.824 -24.633 -21.725 0.50 75.06  ? 397  GLU A OE2 1 
ATOM   908  N  N   . GLU A 1 135 ? -36.813 -28.098 -22.998 0.50 66.28  ? 398  GLU A N   1 
ATOM   909  C  CA  . GLU A 1 135 ? -35.627 -28.978 -23.199 0.50 66.86  ? 398  GLU A CA  1 
ATOM   910  C  C   . GLU A 1 135 ? -34.998 -29.309 -21.840 0.50 67.19  ? 398  GLU A C   1 
ATOM   911  O  O   . GLU A 1 135 ? -34.687 -30.498 -21.599 0.50 64.37  ? 398  GLU A O   1 
ATOM   912  C  CB  . GLU A 1 135 ? -34.569 -28.289 -24.061 0.50 65.71  ? 398  GLU A CB  1 
ATOM   913  C  CG  . GLU A 1 135 ? -34.589 -28.682 -25.522 0.50 65.31  ? 398  GLU A CG  1 
ATOM   914  C  CD  . GLU A 1 135 ? -33.535 -27.958 -26.343 0.50 63.93  ? 398  GLU A CD  1 
ATOM   915  O  OE1 . GLU A 1 135 ? -33.481 -26.714 -26.266 0.50 60.01  ? 398  GLU A OE1 1 
ATOM   916  O  OE2 . GLU A 1 135 ? -32.755 -28.639 -27.034 0.50 65.49  ? 398  GLU A OE2 1 
ATOM   917  N  N   . PHE A 1 136 ? -34.792 -28.275 -21.015 1.00 63.30  ? 399  PHE A N   1 
ATOM   918  C  CA  . PHE A 1 136 ? -34.139 -28.379 -19.687 1.00 65.91  ? 399  PHE A CA  1 
ATOM   919  C  C   . PHE A 1 136 ? -34.971 -29.268 -18.763 1.00 73.09  ? 399  PHE A C   1 
ATOM   920  O  O   . PHE A 1 136 ? -34.398 -30.160 -18.093 1.00 67.99  ? 399  PHE A O   1 
ATOM   921  C  CB  . PHE A 1 136 ? -33.981 -27.000 -19.049 1.00 67.58  ? 399  PHE A CB  1 
ATOM   922  C  CG  . PHE A 1 136 ? -33.152 -26.988 -17.786 1.00 64.94  ? 399  PHE A CG  1 
ATOM   923  C  CD1 . PHE A 1 136 ? -31.794 -27.262 -17.828 1.00 64.02  ? 399  PHE A CD1 1 
ATOM   924  C  CD2 . PHE A 1 136 ? -33.723 -26.675 -16.565 1.00 67.95  ? 399  PHE A CD2 1 
ATOM   925  C  CE1 . PHE A 1 136 ? -31.025 -27.219 -16.679 1.00 65.73  ? 399  PHE A CE1 1 
ATOM   926  C  CE2 . PHE A 1 136 ? -32.950 -26.612 -15.419 1.00 68.08  ? 399  PHE A CE2 1 
ATOM   927  C  CZ  . PHE A 1 136 ? -31.602 -26.881 -15.478 1.00 69.65  ? 399  PHE A CZ  1 
ATOM   928  N  N   . THR A 1 137 ? -36.281 -29.006 -18.702 0.50 72.70  ? 400  THR A N   1 
ATOM   929  C  CA  . THR A 1 137 ? -37.189 -29.768 -17.804 0.50 73.69  ? 400  THR A CA  1 
ATOM   930  C  C   . THR A 1 137 ? -37.105 -31.261 -18.109 0.50 74.16  ? 400  THR A C   1 
ATOM   931  O  O   . THR A 1 137 ? -37.003 -32.052 -17.163 0.50 77.92  ? 400  THR A O   1 
ATOM   932  C  CB  . THR A 1 137 ? -38.636 -29.295 -17.974 0.50 71.73  ? 400  THR A CB  1 
ATOM   933  O  OG1 . THR A 1 137 ? -38.685 -27.900 -17.673 0.50 72.89  ? 400  THR A OG1 1 
ATOM   934  C  CG2 . THR A 1 137 ? -39.610 -30.051 -17.098 0.50 72.77  ? 400  THR A CG2 1 
ATOM   935  N  N   . ARG A 1 138 ? -37.152 -31.623 -19.385 1.00 73.05  ? 401  ARG A N   1 
ATOM   936  C  CA  . ARG A 1 138 ? -37.157 -33.052 -19.767 1.00 79.50  ? 401  ARG A CA  1 
ATOM   937  C  C   . ARG A 1 138 ? -35.864 -33.716 -19.294 1.00 81.48  ? 401  ARG A C   1 
ATOM   938  O  O   . ARG A 1 138 ? -35.940 -34.825 -18.754 1.00 88.33  ? 401  ARG A O   1 
ATOM   939  C  CB  . ARG A 1 138 ? -37.321 -33.164 -21.282 1.00 97.63  ? 401  ARG A CB  1 
ATOM   940  C  CG  . ARG A 1 138 ? -37.489 -34.588 -21.791 1.00 109.86 ? 401  ARG A CG  1 
ATOM   941  C  CD  . ARG A 1 138 ? -38.296 -34.610 -23.074 1.00 110.21 ? 401  ARG A CD  1 
ATOM   942  N  NE  . ARG A 1 138 ? -37.769 -33.677 -24.057 1.00 111.14 ? 401  ARG A NE  1 
ATOM   943  C  CZ  . ARG A 1 138 ? -36.899 -33.998 -25.005 1.00 106.83 ? 401  ARG A CZ  1 
ATOM   944  N  NH1 . ARG A 1 138 ? -36.460 -35.241 -25.105 1.00 109.54 ? 401  ARG A NH1 1 
ATOM   945  N  NH2 . ARG A 1 138 ? -36.473 -33.078 -25.851 1.00 102.66 ? 401  ARG A NH2 1 
ATOM   946  N  N   . LYS A 1 139 ? -34.728 -33.050 -19.487 0.50 81.66  ? 402  LYS A N   1 
ATOM   947  C  CA  . LYS A 1 139 ? -33.430 -33.645 -19.092 0.50 83.38  ? 402  LYS A CA  1 
ATOM   948  C  C   . LYS A 1 139 ? -33.473 -33.937 -17.593 0.50 90.76  ? 402  LYS A C   1 
ATOM   949  O  O   . LYS A 1 139 ? -32.999 -35.013 -17.186 0.50 93.41  ? 402  LYS A O   1 
ATOM   950  C  CB  . LYS A 1 139 ? -32.285 -32.683 -19.414 0.50 81.41  ? 402  LYS A CB  1 
ATOM   951  C  CG  . LYS A 1 139 ? -32.220 -32.214 -20.861 0.50 80.23  ? 402  LYS A CG  1 
ATOM   952  C  CD  . LYS A 1 139 ? -31.094 -31.237 -21.120 0.50 80.28  ? 402  LYS A CD  1 
ATOM   953  C  CE  . LYS A 1 139 ? -29.728 -31.823 -20.836 0.50 77.84  ? 402  LYS A CE  1 
ATOM   954  N  NZ  . LYS A 1 139 ? -29.456 -33.011 -21.678 0.50 77.07  ? 402  LYS A NZ  1 
ATOM   955  N  N   . VAL A 1 140 ? -34.026 -33.009 -16.811 1.00 94.53  ? 403  VAL A N   1 
ATOM   956  C  CA  . VAL A 1 140 ? -34.054 -33.169 -15.329 1.00 103.60 ? 403  VAL A CA  1 
ATOM   957  C  C   . VAL A 1 140 ? -35.082 -34.242 -14.964 1.00 111.45 ? 403  VAL A C   1 
ATOM   958  O  O   . VAL A 1 140 ? -34.847 -34.968 -13.981 1.00 113.90 ? 403  VAL A O   1 
ATOM   959  C  CB  . VAL A 1 140 ? -34.351 -31.835 -14.616 1.00 105.84 ? 403  VAL A CB  1 
ATOM   960  C  CG1 . VAL A 1 140 ? -33.563 -30.682 -15.214 1.00 106.09 ? 403  VAL A CG1 1 
ATOM   961  C  CG2 . VAL A 1 140 ? -35.835 -31.514 -14.575 1.00 110.20 ? 403  VAL A CG2 1 
ATOM   962  N  N   . ARG A 1 141 ? -36.171 -34.329 -15.728 1.00 101.16 ? 404  ARG A N   1 
ATOM   963  C  CA  . ARG A 1 141 ? -37.222 -35.339 -15.453 1.00 98.09  ? 404  ARG A CA  1 
ATOM   964  C  C   . ARG A 1 141 ? -36.744 -36.667 -16.027 1.00 93.64  ? 404  ARG A C   1 
ATOM   965  O  O   . ARG A 1 141 ? -37.537 -37.614 -16.050 1.00 109.24 ? 404  ARG A O   1 
ATOM   966  C  CB  . ARG A 1 141 ? -38.568 -34.898 -16.030 1.00 92.35  ? 404  ARG A CB  1 
ATOM   967  C  CG  . ARG A 1 141 ? -39.147 -33.674 -15.335 1.00 107.97 ? 404  ARG A CG  1 
ATOM   968  C  CD  . ARG A 1 141 ? -40.629 -33.818 -15.052 1.00 118.70 ? 404  ARG A CD  1 
ATOM   969  N  NE  . ARG A 1 141 ? -41.463 -33.459 -16.189 1.00 119.76 ? 404  ARG A NE  1 
ATOM   970  C  CZ  . ARG A 1 141 ? -42.109 -32.306 -16.306 1.00 119.31 ? 404  ARG A CZ  1 
ATOM   971  N  NH1 . ARG A 1 141 ? -42.026 -31.403 -15.344 1.00 116.89 ? 404  ARG A NH1 1 
ATOM   972  N  NH2 . ARG A 1 141 ? -42.845 -32.066 -17.375 1.00 119.40 ? 404  ARG A NH2 1 
ATOM   973  N  N   . SER A 1 142 ? -35.494 -36.708 -16.482 1.00 102.31 ? 405  SER A N   1 
ATOM   974  C  CA  . SER A 1 142 ? -34.907 -37.966 -17.003 1.00 110.74 ? 405  SER A CA  1 
ATOM   975  C  C   . SER A 1 142 ? -33.556 -38.205 -16.329 1.00 116.25 ? 405  SER A C   1 
ATOM   976  O  O   . SER A 1 142 ? -32.798 -39.039 -16.847 1.00 123.81 ? 405  SER A O   1 
ATOM   977  C  CB  . SER A 1 142 ? -34.769 -37.915 -18.494 1.00 108.02 ? 405  SER A CB  1 
ATOM   978  O  OG  . SER A 1 142 ? -34.027 -36.771 -18.884 1.00 114.84 ? 405  SER A OG  1 
ATOM   979  N  N   . ASN A 1 143 ? -33.268 -37.486 -15.239 0.50 116.00 ? 406  ASN A N   1 
ATOM   980  C  CA  . ASN A 1 143 ? -32.009 -37.687 -14.466 0.50 116.26 ? 406  ASN A CA  1 
ATOM   981  C  C   . ASN A 1 143 ? -30.779 -37.384 -15.325 0.50 118.36 ? 406  ASN A C   1 
ATOM   982  O  O   . ASN A 1 143 ? -30.537 -38.120 -16.295 0.50 119.47 ? 406  ASN A O   1 
ATOM   983  C  CB  . ASN A 1 143 ? -31.915 -39.086 -13.848 0.50 113.44 ? 406  ASN A CB  1 
ATOM   984  C  CG  . ASN A 1 143 ? -32.555 -39.170 -12.480 0.50 108.87 ? 406  ASN A CG  1 
ATOM   985  O  OD1 . ASN A 1 143 ? -33.228 -38.238 -12.046 0.50 106.00 ? 406  ASN A OD1 1 
ATOM   986  N  ND2 . ASN A 1 143 ? -32.346 -40.280 -11.791 0.50 109.72 ? 406  ASN A ND2 1 
ATOM   987  N  N   . ALA A 1 144 ? -30.019 -36.350 -14.960 0.50 123.48 ? 407  ALA A N   1 
ATOM   988  C  CA  . ALA A 1 144 ? -28.769 -36.028 -15.686 0.50 127.19 ? 407  ALA A CA  1 
ATOM   989  C  C   . ALA A 1 144 ? -27.922 -35.081 -14.832 0.50 130.19 ? 407  ALA A C   1 
ATOM   990  O  O   . ALA A 1 144 ? -28.501 -34.361 -13.997 0.50 128.74 ? 407  ALA A O   1 
ATOM   991  C  CB  . ALA A 1 144 ? -29.087 -35.421 -17.028 0.50 124.47 ? 407  ALA A CB  1 
ATOM   992  N  N   . ALA A 1 145 ? -26.606 -35.077 -15.049 0.50 131.89 ? 408  ALA A N   1 
ATOM   993  C  CA  . ALA A 1 145 ? -25.702 -34.204 -14.266 0.50 129.90 ? 408  ALA A CA  1 
ATOM   994  C  C   . ALA A 1 145 ? -25.958 -32.734 -14.614 0.50 129.81 ? 408  ALA A C   1 
ATOM   995  O  O   . ALA A 1 145 ? -25.728 -32.355 -15.777 0.50 130.76 ? 408  ALA A O   1 
ATOM   996  C  CB  . ALA A 1 145 ? -24.270 -34.598 -14.512 0.50 126.32 ? 408  ALA A CB  1 
ATOM   997  N  N   . LEU A 1 146 ? -26.413 -31.945 -13.640 0.50 127.68 ? 409  LEU A N   1 
ATOM   998  C  CA  . LEU A 1 146 ? -26.700 -30.498 -13.835 0.50 126.56 ? 409  LEU A CA  1 
ATOM   999  C  C   . LEU A 1 146 ? -26.480 -29.752 -12.511 0.50 126.25 ? 409  LEU A C   1 
ATOM   1000 O  O   . LEU A 1 146 ? -27.387 -29.001 -12.098 0.50 128.48 ? 409  LEU A O   1 
ATOM   1001 C  CB  . LEU A 1 146 ? -28.141 -30.335 -14.330 0.50 124.34 ? 409  LEU A CB  1 
ATOM   1002 C  CG  . LEU A 1 146 ? -28.400 -30.781 -15.768 0.50 123.72 ? 409  LEU A CG  1 
ATOM   1003 C  CD1 . LEU A 1 146 ? -29.892 -30.827 -16.063 0.50 121.87 ? 409  LEU A CD1 1 
ATOM   1004 C  CD2 . LEU A 1 146 ? -27.689 -29.871 -16.758 0.50 122.47 ? 409  LEU A CD2 1 
ATOM   1005 N  N   . GLY A 1 147 ? -25.318 -29.956 -11.879 0.50 121.41 ? 410  GLY A N   1 
ATOM   1006 C  CA  . GLY A 1 147 ? -24.941 -29.330 -10.596 0.50 115.85 ? 410  GLY A CA  1 
ATOM   1007 C  C   . GLY A 1 147 ? -26.053 -28.454 -10.045 0.50 111.33 ? 410  GLY A C   1 
ATOM   1008 O  O   . GLY A 1 147 ? -26.705 -28.902 -9.081  0.50 104.66 ? 410  GLY A O   1 
ATOM   1009 N  N   . LYS A 1 155 ? -36.275 -24.476 -0.411  0.50 77.59  ? 418  LYS A N   1 
ATOM   1010 C  CA  . LYS A 1 155 ? -37.585 -24.255 -1.078  0.50 80.44  ? 418  LYS A CA  1 
ATOM   1011 C  C   . LYS A 1 155 ? -38.004 -25.548 -1.786  0.50 79.28  ? 418  LYS A C   1 
ATOM   1012 O  O   . LYS A 1 155 ? -39.128 -26.020 -1.535  0.50 77.03  ? 418  LYS A O   1 
ATOM   1013 C  CB  . LYS A 1 155 ? -37.485 -23.083 -2.059  0.50 82.20  ? 418  LYS A CB  1 
ATOM   1014 C  CG  . LYS A 1 155 ? -38.741 -22.236 -2.204  0.50 82.70  ? 418  LYS A CG  1 
ATOM   1015 C  CD  . LYS A 1 155 ? -39.951 -23.015 -2.667  0.50 82.74  ? 418  LYS A CD  1 
ATOM   1016 C  CE  . LYS A 1 155 ? -41.201 -22.166 -2.741  0.50 82.43  ? 418  LYS A CE  1 
ATOM   1017 N  NZ  . LYS A 1 155 ? -42.375 -22.956 -3.182  0.50 83.11  ? 418  LYS A NZ  1 
ATOM   1018 N  N   . TRP A 1 156 ? -37.126 -26.096 -2.631  0.50 79.56  ? 419  TRP A N   1 
ATOM   1019 C  CA  . TRP A 1 156 ? -37.433 -27.357 -3.358  0.50 79.05  ? 419  TRP A CA  1 
ATOM   1020 C  C   . TRP A 1 156 ? -36.375 -28.412 -3.027  0.50 81.52  ? 419  TRP A C   1 
ATOM   1021 O  O   . TRP A 1 156 ? -35.177 -28.088 -3.110  0.50 78.70  ? 419  TRP A O   1 
ATOM   1022 C  CB  . TRP A 1 156 ? -37.507 -27.110 -4.867  0.50 76.21  ? 419  TRP A CB  1 
ATOM   1023 C  CG  . TRP A 1 156 ? -38.036 -25.761 -5.241  0.50 72.30  ? 419  TRP A CG  1 
ATOM   1024 C  CD1 . TRP A 1 156 ? -39.338 -25.421 -5.462  0.50 71.05  ? 419  TRP A CD1 1 
ATOM   1025 C  CD2 . TRP A 1 156 ? -37.268 -24.562 -5.446  0.50 69.74  ? 419  TRP A CD2 1 
ATOM   1026 N  NE1 . TRP A 1 156 ? -39.432 -24.096 -5.788  0.50 71.23  ? 419  TRP A NE1 1 
ATOM   1027 C  CE2 . TRP A 1 156 ? -38.180 -23.542 -5.786  0.50 68.05  ? 419  TRP A CE2 1 
ATOM   1028 C  CE3 . TRP A 1 156 ? -35.907 -24.251 -5.375  0.50 69.38  ? 419  TRP A CE3 1 
ATOM   1029 C  CZ2 . TRP A 1 156 ? -37.774 -22.237 -6.053  0.50 69.29  ? 419  TRP A CZ2 1 
ATOM   1030 C  CZ3 . TRP A 1 156 ? -35.505 -22.962 -5.639  0.50 68.40  ? 419  TRP A CZ3 1 
ATOM   1031 C  CH2 . TRP A 1 156 ? -36.427 -21.970 -5.973  0.50 68.71  ? 419  TRP A CH2 1 
ATOM   1032 N  N   . LYS A 1 157 ? -36.810 -29.623 -2.672  0.50 85.83  ? 420  LYS A N   1 
ATOM   1033 C  CA  . LYS A 1 157 ? -35.867 -30.727 -2.364  0.50 87.30  ? 420  LYS A CA  1 
ATOM   1034 C  C   . LYS A 1 157 ? -35.126 -31.116 -3.643  0.50 88.65  ? 420  LYS A C   1 
ATOM   1035 O  O   . LYS A 1 157 ? -34.010 -30.608 -3.858  0.50 87.54  ? 420  LYS A O   1 
ATOM   1036 C  CB  . LYS A 1 157 ? -36.646 -31.926 -1.820  0.50 90.36  ? 420  LYS A CB  1 
ATOM   1037 C  CG  . LYS A 1 157 ? -35.870 -33.231 -1.716  0.50 90.57  ? 420  LYS A CG  1 
ATOM   1038 C  CD  . LYS A 1 157 ? -36.669 -34.412 -2.219  0.50 92.00  ? 420  LYS A CD  1 
ATOM   1039 C  CE  . LYS A 1 157 ? -38.067 -34.460 -1.641  0.50 87.93  ? 420  LYS A CE  1 
ATOM   1040 N  NZ  . LYS A 1 157 ? -38.902 -35.488 -2.306  0.50 87.97  ? 420  LYS A NZ  1 
ATOM   1041 N  N   . SER A 1 158 ? -35.737 -31.979 -4.456  0.50 88.98  ? 421  SER A N   1 
ATOM   1042 C  CA  . SER A 1 158 ? -35.110 -32.423 -5.725  0.50 87.58  ? 421  SER A CA  1 
ATOM   1043 C  C   . SER A 1 158 ? -35.220 -31.310 -6.767  0.50 89.68  ? 421  SER A C   1 
ATOM   1044 O  O   . SER A 1 158 ? -36.066 -30.414 -6.585  0.50 85.91  ? 421  SER A O   1 
ATOM   1045 C  CB  . SER A 1 158 ? -35.754 -33.686 -6.210  0.50 85.67  ? 421  SER A CB  1 
ATOM   1046 O  OG  . SER A 1 158 ? -37.161 -33.526 -6.306  0.50 84.47  ? 421  SER A OG  1 
ATOM   1047 N  N   . ALA A 1 159 ? -34.396 -31.372 -7.816  0.50 90.91  ? 422  ALA A N   1 
ATOM   1048 C  CA  . ALA A 1 159 ? -34.459 -30.365 -8.900  0.50 90.38  ? 422  ALA A CA  1 
ATOM   1049 C  C   . ALA A 1 159 ? -35.683 -30.642 -9.776  0.50 88.05  ? 422  ALA A C   1 
ATOM   1050 O  O   . ALA A 1 159 ? -36.129 -29.722 -10.480 0.50 79.87  ? 422  ALA A O   1 
ATOM   1051 C  CB  . ALA A 1 159 ? -33.185 -30.407 -9.700  0.50 93.12  ? 422  ALA A CB  1 
ATOM   1052 N  N   . ARG A 1 160 ? -36.195 -31.871 -9.746  0.50 90.66  ? 423  ARG A N   1 
ATOM   1053 C  CA  . ARG A 1 160 ? -37.425 -32.184 -10.514 0.50 91.18  ? 423  ARG A CA  1 
ATOM   1054 C  C   . ARG A 1 160 ? -38.556 -31.296 -9.986  0.50 93.90  ? 423  ARG A C   1 
ATOM   1055 O  O   . ARG A 1 160 ? -39.316 -30.746 -10.810 0.50 93.41  ? 423  ARG A O   1 
ATOM   1056 C  CB  . ARG A 1 160 ? -37.730 -33.680 -10.399 0.50 91.86  ? 423  ARG A CB  1 
ATOM   1057 C  CG  . ARG A 1 160 ? -38.746 -34.187 -11.411 0.50 97.22  ? 423  ARG A CG  1 
ATOM   1058 C  CD  . ARG A 1 160 ? -38.677 -35.693 -11.587 0.50 100.26 ? 423  ARG A CD  1 
ATOM   1059 N  NE  . ARG A 1 160 ? -37.358 -36.136 -12.016 0.50 102.26 ? 423  ARG A NE  1 
ATOM   1060 C  CZ  . ARG A 1 160 ? -37.049 -37.388 -12.333 0.50 102.62 ? 423  ARG A CZ  1 
ATOM   1061 N  NH1 . ARG A 1 160 ? -35.820 -37.690 -12.713 0.50 102.59 ? 423  ARG A NH1 1 
ATOM   1062 N  NH2 . ARG A 1 160 ? -37.971 -38.332 -12.274 0.50 102.58 ? 423  ARG A NH2 1 
ATOM   1063 N  N   . GLU A 1 161 ? -38.635 -31.127 -8.665  0.50 99.05  ? 424  GLU A N   1 
ATOM   1064 C  CA  . GLU A 1 161 ? -39.704 -30.302 -8.045  0.50 99.37  ? 424  GLU A CA  1 
ATOM   1065 C  C   . GLU A 1 161 ? -39.568 -28.845 -8.486  0.50 97.95  ? 424  GLU A C   1 
ATOM   1066 O  O   . GLU A 1 161 ? -40.600 -28.236 -8.824  0.50 95.19  ? 424  GLU A O   1 
ATOM   1067 C  CB  . GLU A 1 161 ? -39.595 -30.367 -6.522  0.50 104.14 ? 424  GLU A CB  1 
ATOM   1068 C  CG  . GLU A 1 161 ? -39.746 -31.766 -5.957  0.50 108.57 ? 424  GLU A CG  1 
ATOM   1069 C  CD  . GLU A 1 161 ? -39.623 -31.838 -4.445  0.50 109.54 ? 424  GLU A CD  1 
ATOM   1070 O  OE1 . GLU A 1 161 ? -39.275 -30.809 -3.831  0.50 106.35 ? 424  GLU A OE1 1 
ATOM   1071 O  OE2 . GLU A 1 161 ? -39.880 -32.922 -3.884  0.50 106.69 ? 424  GLU A OE2 1 
ATOM   1072 N  N   . ALA A 1 162 ? -38.345 -28.310 -8.478  0.50 95.53  ? 425  ALA A N   1 
ATOM   1073 C  CA  . ALA A 1 162 ? -38.138 -26.883 -8.814  0.50 94.90  ? 425  ALA A CA  1 
ATOM   1074 C  C   . ALA A 1 162 ? -38.589 -26.607 -10.250 0.50 94.85  ? 425  ALA A C   1 
ATOM   1075 O  O   . ALA A 1 162 ? -39.182 -25.539 -10.483 0.50 92.35  ? 425  ALA A O   1 
ATOM   1076 C  CB  . ALA A 1 162 ? -36.689 -26.522 -8.617  0.50 94.92  ? 425  ALA A CB  1 
ATOM   1077 N  N   . VAL A 1 163 ? -38.325 -27.538 -11.168 0.50 97.61  ? 426  VAL A N   1 
ATOM   1078 C  CA  . VAL A 1 163 ? -38.660 -27.320 -12.607 0.50 101.62 ? 426  VAL A CA  1 
ATOM   1079 C  C   . VAL A 1 163 ? -40.180 -27.215 -12.739 0.50 102.81 ? 426  VAL A C   1 
ATOM   1080 O  O   . VAL A 1 163 ? -40.650 -26.682 -13.759 0.50 100.09 ? 426  VAL A O   1 
ATOM   1081 C  CB  . VAL A 1 163 ? -38.092 -28.448 -13.489 0.50 102.83 ? 426  VAL A CB  1 
ATOM   1082 C  CG1 . VAL A 1 163 ? -39.107 -29.556 -13.719 0.50 101.46 ? 426  VAL A CG1 1 
ATOM   1083 C  CG2 . VAL A 1 163 ? -37.569 -27.917 -14.813 0.50 104.05 ? 426  VAL A CG2 1 
ATOM   1084 N  N   . GLU A 1 164 ? -40.909 -27.706 -11.736 0.50 111.01 ? 427  GLU A N   1 
ATOM   1085 C  CA  . GLU A 1 164 ? -42.394 -27.666 -11.770 0.50 113.53 ? 427  GLU A CA  1 
ATOM   1086 C  C   . GLU A 1 164 ? -42.906 -26.439 -11.007 0.50 112.74 ? 427  GLU A C   1 
ATOM   1087 O  O   . GLU A 1 164 ? -44.122 -26.188 -11.061 0.50 110.49 ? 427  GLU A O   1 
ATOM   1088 C  CB  . GLU A 1 164 ? -42.941 -28.958 -11.166 0.50 116.35 ? 427  GLU A CB  1 
ATOM   1089 C  CG  . GLU A 1 164 ? -42.396 -30.206 -11.836 0.50 119.30 ? 427  GLU A CG  1 
ATOM   1090 C  CD  . GLU A 1 164 ? -42.427 -31.450 -10.966 0.50 123.22 ? 427  GLU A CD  1 
ATOM   1091 O  OE1 . GLU A 1 164 ? -42.673 -31.311 -9.751  0.50 122.11 ? 427  GLU A OE1 1 
ATOM   1092 O  OE2 . GLU A 1 164 ? -42.205 -32.553 -11.504 0.50 125.78 ? 427  GLU A OE2 1 
ATOM   1093 N  N   . ASP A 1 165 ? -42.017 -25.699 -10.337 0.50 115.90 ? 428  ASP A N   1 
ATOM   1094 C  CA  . ASP A 1 165 ? -42.451 -24.541 -9.507  0.50 114.59 ? 428  ASP A CA  1 
ATOM   1095 C  C   . ASP A 1 165 ? -42.263 -23.236 -10.283 0.50 109.65 ? 428  ASP A C   1 
ATOM   1096 O  O   . ASP A 1 165 ? -41.107 -22.884 -10.578 0.50 107.26 ? 428  ASP A O   1 
ATOM   1097 C  CB  . ASP A 1 165 ? -41.714 -24.488 -8.167  0.50 117.56 ? 428  ASP A CB  1 
ATOM   1098 C  CG  . ASP A 1 165 ? -42.236 -23.411 -7.231  0.50 117.88 ? 428  ASP A CG  1 
ATOM   1099 O  OD1 . ASP A 1 165 ? -42.809 -22.424 -7.731  0.50 115.70 ? 428  ASP A OD1 1 
ATOM   1100 O  OD2 . ASP A 1 165 ? -42.080 -23.574 -6.006  0.50 120.05 ? 428  ASP A OD2 1 
ATOM   1101 N  N   . SER A 1 166 ? -43.364 -22.537 -10.558 0.50 103.28 ? 429  SER A N   1 
ATOM   1102 C  CA  . SER A 1 166 ? -43.299 -21.262 -11.312 0.50 100.03 ? 429  SER A CA  1 
ATOM   1103 C  C   . SER A 1 166 ? -42.390 -20.273 -10.585 0.50 94.96  ? 429  SER A C   1 
ATOM   1104 O  O   . SER A 1 166 ? -41.683 -19.511 -11.266 0.50 96.04  ? 429  SER A O   1 
ATOM   1105 C  CB  . SER A 1 166 ? -44.677 -20.700 -11.491 0.50 104.32 ? 429  SER A CB  1 
ATOM   1106 O  OG  . SER A 1 166 ? -45.545 -21.673 -12.052 0.50 108.73 ? 429  SER A OG  1 
ATOM   1107 N  N   . GLY A 1 167 ? -42.420 -20.283 -9.252  0.50 91.62  ? 430  GLY A N   1 
ATOM   1108 C  CA  . GLY A 1 167 ? -41.601 -19.337 -8.468  0.50 88.57  ? 430  GLY A CA  1 
ATOM   1109 C  C   . GLY A 1 167 ? -40.159 -19.354 -8.939  0.50 86.78  ? 430  GLY A C   1 
ATOM   1110 O  O   . GLY A 1 167 ? -39.623 -18.276 -9.243  0.50 87.10  ? 430  GLY A O   1 
ATOM   1111 N  N   . PHE A 1 168 ? -39.564 -20.548 -9.002  0.50 86.55  ? 431  PHE A N   1 
ATOM   1112 C  CA  . PHE A 1 168 ? -38.221 -20.815 -9.579  0.50 87.21  ? 431  PHE A CA  1 
ATOM   1113 C  C   . PHE A 1 168 ? -38.050 -19.984 -10.856 0.50 80.74  ? 431  PHE A C   1 
ATOM   1114 O  O   . PHE A 1 168 ? -37.162 -19.108 -10.883 0.50 78.18  ? 431  PHE A O   1 
ATOM   1115 C  CB  . PHE A 1 168 ? -38.056 -22.315 -9.840  0.50 92.06  ? 431  PHE A CB  1 
ATOM   1116 C  CG  . PHE A 1 168 ? -36.807 -22.705 -10.589 0.50 93.50  ? 431  PHE A CG  1 
ATOM   1117 C  CD1 . PHE A 1 168 ? -35.624 -22.966 -9.915  0.50 94.80  ? 431  PHE A CD1 1 
ATOM   1118 C  CD2 . PHE A 1 168 ? -36.818 -22.829 -11.969 0.50 95.50  ? 431  PHE A CD2 1 
ATOM   1119 C  CE1 . PHE A 1 168 ? -34.479 -23.331 -10.604 0.50 94.46  ? 431  PHE A CE1 1 
ATOM   1120 C  CE2 . PHE A 1 168 ? -35.671 -23.194 -12.656 0.50 96.36  ? 431  PHE A CE2 1 
ATOM   1121 C  CZ  . PHE A 1 168 ? -34.505 -23.445 -11.973 0.50 96.25  ? 431  PHE A CZ  1 
ATOM   1122 N  N   . TRP A 1 169 ? -38.897 -20.237 -11.861 1.00 78.67  ? 432  TRP A N   1 
ATOM   1123 C  CA  . TRP A 1 169 ? -38.834 -19.553 -13.186 1.00 76.15  ? 432  TRP A CA  1 
ATOM   1124 C  C   . TRP A 1 169 ? -38.935 -18.020 -13.082 1.00 81.51  ? 432  TRP A C   1 
ATOM   1125 O  O   . TRP A 1 169 ? -38.402 -17.323 -13.965 1.00 86.85  ? 432  TRP A O   1 
ATOM   1126 C  CB  . TRP A 1 169 ? -39.871 -20.119 -14.154 1.00 67.30  ? 432  TRP A CB  1 
ATOM   1127 C  CG  . TRP A 1 169 ? -39.669 -21.573 -14.424 1.00 71.01  ? 432  TRP A CG  1 
ATOM   1128 C  CD1 . TRP A 1 169 ? -40.516 -22.577 -14.070 1.00 76.37  ? 432  TRP A CD1 1 
ATOM   1129 C  CD2 . TRP A 1 169 ? -38.539 -22.207 -15.058 1.00 72.14  ? 432  TRP A CD2 1 
ATOM   1130 N  NE1 . TRP A 1 169 ? -39.998 -23.787 -14.440 1.00 80.58  ? 432  TRP A NE1 1 
ATOM   1131 C  CE2 . TRP A 1 169 ? -38.791 -23.596 -15.059 1.00 74.21  ? 432  TRP A CE2 1 
ATOM   1132 C  CE3 . TRP A 1 169 ? -37.344 -21.751 -15.629 1.00 74.55  ? 432  TRP A CE3 1 
ATOM   1133 C  CZ2 . TRP A 1 169 ? -37.903 -24.523 -15.610 1.00 73.72  ? 432  TRP A CZ2 1 
ATOM   1134 C  CZ3 . TRP A 1 169 ? -36.471 -22.667 -16.186 1.00 73.71  ? 432  TRP A CZ3 1 
ATOM   1135 C  CH2 . TRP A 1 169 ? -36.744 -24.035 -16.172 1.00 70.67  ? 432  TRP A CH2 1 
ATOM   1136 N  N   . GLU A 1 170 ? -39.613 -17.525 -12.042 0.50 85.40  ? 433  GLU A N   1 
ATOM   1137 C  CA  . GLU A 1 170 ? -39.718 -16.078 -11.715 0.50 89.10  ? 433  GLU A CA  1 
ATOM   1138 C  C   . GLU A 1 170 ? -38.333 -15.585 -11.279 0.50 86.71  ? 433  GLU A C   1 
ATOM   1139 O  O   . GLU A 1 170 ? -37.935 -14.476 -11.680 0.50 86.48  ? 433  GLU A O   1 
ATOM   1140 C  CB  . GLU A 1 170 ? -40.777 -15.869 -10.630 0.50 93.09  ? 433  GLU A CB  1 
ATOM   1141 C  CG  . GLU A 1 170 ? -42.110 -16.525 -10.960 0.50 97.54  ? 433  GLU A CG  1 
ATOM   1142 C  CD  . GLU A 1 170 ? -42.863 -17.096 -9.769  0.50 99.89  ? 433  GLU A CD  1 
ATOM   1143 O  OE1 . GLU A 1 170 ? -42.349 -16.983 -8.632  0.50 100.83 ? 433  GLU A OE1 1 
ATOM   1144 O  OE2 . GLU A 1 170 ? -43.963 -17.659 -9.979  0.50 92.20  ? 433  GLU A OE2 1 
ATOM   1145 N  N   . LEU A 1 171 ? -37.626 -16.406 -10.500 0.50 85.79  ? 434  LEU A N   1 
ATOM   1146 C  CA  . LEU A 1 171 ? -36.228 -16.155 -10.064 0.50 89.95  ? 434  LEU A CA  1 
ATOM   1147 C  C   . LEU A 1 171 ? -35.321 -16.128 -11.301 0.50 87.35  ? 434  LEU A C   1 
ATOM   1148 O  O   . LEU A 1 171 ? -34.595 -15.128 -11.480 0.50 78.66  ? 434  LEU A O   1 
ATOM   1149 C  CB  . LEU A 1 171 ? -35.818 -17.258 -9.084  0.50 93.38  ? 434  LEU A CB  1 
ATOM   1150 C  CG  . LEU A 1 171 ? -36.722 -17.405 -7.860  0.50 99.06  ? 434  LEU A CG  1 
ATOM   1151 C  CD1 . LEU A 1 171 ? -36.238 -18.529 -6.955  0.50 100.26 ? 434  LEU A CD1 1 
ATOM   1152 C  CD2 . LEU A 1 171 ? -36.811 -16.095 -7.086  0.50 98.99  ? 434  LEU A CD2 1 
ATOM   1153 N  N   . VAL A 1 172 ? -35.389 -17.182 -12.124 0.50 84.19  ? 435  VAL A N   1 
ATOM   1154 C  CA  . VAL A 1 172 ? -34.628 -17.326 -13.401 0.50 79.83  ? 435  VAL A CA  1 
ATOM   1155 C  C   . VAL A 1 172 ? -34.799 -16.045 -14.223 0.50 78.12  ? 435  VAL A C   1 
ATOM   1156 O  O   . VAL A 1 172 ? -33.773 -15.452 -14.616 0.50 68.98  ? 435  VAL A O   1 
ATOM   1157 C  CB  . VAL A 1 172 ? -35.089 -18.563 -14.195 0.50 81.42  ? 435  VAL A CB  1 
ATOM   1158 C  CG1 . VAL A 1 172 ? -34.415 -18.634 -15.556 0.50 82.28  ? 435  VAL A CG1 1 
ATOM   1159 C  CG2 . VAL A 1 172 ? -34.866 -19.852 -13.416 0.50 81.54  ? 435  VAL A CG2 1 
ATOM   1160 N  N   . ASP A 1 173 ? -36.052 -15.639 -14.460 0.50 82.02  ? 436  ASP A N   1 
ATOM   1161 C  CA  . ASP A 1 173 ? -36.411 -14.416 -15.227 0.50 83.15  ? 436  ASP A CA  1 
ATOM   1162 C  C   . ASP A 1 173 ? -35.671 -13.217 -14.629 0.50 78.83  ? 436  ASP A C   1 
ATOM   1163 O  O   . ASP A 1 173 ? -35.080 -12.437 -15.401 0.50 78.05  ? 436  ASP A O   1 
ATOM   1164 C  CB  . ASP A 1 173 ? -37.922 -14.171 -15.226 0.50 91.49  ? 436  ASP A CB  1 
ATOM   1165 C  CG  . ASP A 1 173 ? -38.671 -14.953 -16.291 0.50 97.86  ? 436  ASP A CG  1 
ATOM   1166 O  OD1 . ASP A 1 173 ? -38.067 -15.228 -17.353 0.50 97.58  ? 436  ASP A OD1 1 
ATOM   1167 O  OD2 . ASP A 1 173 ? -39.852 -15.288 -16.049 0.50 104.31 ? 436  ASP A OD2 1 
ATOM   1168 N  N   . LYS A 1 174 ? -35.713 -13.073 -13.304 0.50 78.90  ? 437  LYS A N   1 
ATOM   1169 C  CA  . LYS A 1 174 ? -35.066 -11.941 -12.590 0.50 78.83  ? 437  LYS A CA  1 
ATOM   1170 C  C   . LYS A 1 174 ? -33.586 -11.910 -12.983 0.50 76.13  ? 437  LYS A C   1 
ATOM   1171 O  O   . LYS A 1 174 ? -33.112 -10.845 -13.435 0.50 74.28  ? 437  LYS A O   1 
ATOM   1172 C  CB  . LYS A 1 174 ? -35.253 -12.074 -11.076 0.50 80.13  ? 437  LYS A CB  1 
ATOM   1173 C  CG  . LYS A 1 174 ? -34.763 -10.882 -10.263 0.50 84.20  ? 437  LYS A CG  1 
ATOM   1174 C  CD  . LYS A 1 174 ? -35.030 -11.008 -8.776  0.50 85.56  ? 437  LYS A CD  1 
ATOM   1175 C  CE  . LYS A 1 174 ? -34.392 -9.902  -7.963  0.50 85.90  ? 437  LYS A CE  1 
ATOM   1176 N  NZ  . LYS A 1 174 ? -34.768 -9.999  -6.533  0.50 86.78  ? 437  LYS A NZ  1 
ATOM   1177 N  N   . GLU A 1 175 ? -32.896 -13.048 -12.842 0.50 75.24  ? 438  GLU A N   1 
ATOM   1178 C  CA  . GLU A 1 175 ? -31.449 -13.195 -13.154 0.50 71.88  ? 438  GLU A CA  1 
ATOM   1179 C  C   . GLU A 1 175 ? -31.218 -12.917 -14.643 0.50 67.74  ? 438  GLU A C   1 
ATOM   1180 O  O   . GLU A 1 175 ? -30.308 -12.125 -14.960 0.50 63.94  ? 438  GLU A O   1 
ATOM   1181 C  CB  . GLU A 1 175 ? -30.955 -14.587 -12.762 0.50 74.04  ? 438  GLU A CB  1 
ATOM   1182 C  CG  . GLU A 1 175 ? -30.121 -14.585 -11.496 0.50 76.76  ? 438  GLU A CG  1 
ATOM   1183 C  CD  . GLU A 1 175 ? -28.709 -14.066 -11.691 0.50 76.24  ? 438  GLU A CD  1 
ATOM   1184 O  OE1 . GLU A 1 175 ? -28.010 -14.596 -12.575 0.50 76.59  ? 438  GLU A OE1 1 
ATOM   1185 O  OE2 . GLU A 1 175 ? -28.316 -13.128 -10.970 0.50 75.63  ? 438  GLU A OE2 1 
ATOM   1186 N  N   . ARG A 1 176 ? -32.016 -13.544 -15.512 0.50 65.03  ? 439  ARG A N   1 
ATOM   1187 C  CA  . ARG A 1 176 ? -31.932 -13.382 -16.988 0.50 66.81  ? 439  ARG A CA  1 
ATOM   1188 C  C   . ARG A 1 176 ? -31.934 -11.889 -17.332 0.50 68.44  ? 439  ARG A C   1 
ATOM   1189 O  O   . ARG A 1 176 ? -31.019 -11.451 -18.056 0.50 71.63  ? 439  ARG A O   1 
ATOM   1190 C  CB  . ARG A 1 176 ? -33.093 -14.110 -17.669 0.50 71.28  ? 439  ARG A CB  1 
ATOM   1191 C  CG  . ARG A 1 176 ? -33.000 -14.147 -19.186 0.50 74.08  ? 439  ARG A CG  1 
ATOM   1192 C  CD  . ARG A 1 176 ? -33.921 -15.200 -19.770 0.50 79.16  ? 439  ARG A CD  1 
ATOM   1193 N  NE  . ARG A 1 176 ? -34.093 -15.028 -21.206 0.50 88.82  ? 439  ARG A NE  1 
ATOM   1194 C  CZ  . ARG A 1 176 ? -34.911 -15.755 -21.958 0.50 94.06  ? 439  ARG A CZ  1 
ATOM   1195 N  NH1 . ARG A 1 176 ? -35.638 -16.711 -21.402 0.50 100.43 ? 439  ARG A NH1 1 
ATOM   1196 N  NH2 . ARG A 1 176 ? -34.999 -15.526 -23.257 0.50 89.16  ? 439  ARG A NH2 1 
ATOM   1197 N  N   . ASN A 1 177 ? -32.918 -11.136 -16.828 0.50 69.09  ? 440  ASN A N   1 
ATOM   1198 C  CA  . ASN A 1 177 ? -33.062 -9.677  -17.087 0.50 66.94  ? 440  ASN A CA  1 
ATOM   1199 C  C   . ASN A 1 177 ? -31.828 -8.952  -16.543 0.50 62.62  ? 440  ASN A C   1 
ATOM   1200 O  O   . ASN A 1 177 ? -31.355 -8.013  -17.212 0.50 60.94  ? 440  ASN A O   1 
ATOM   1201 C  CB  . ASN A 1 177 ? -34.374 -9.128  -16.519 0.50 73.41  ? 440  ASN A CB  1 
ATOM   1202 C  CG  . ASN A 1 177 ? -35.567 -9.457  -17.392 0.50 76.90  ? 440  ASN A CG  1 
ATOM   1203 O  OD1 . ASN A 1 177 ? -35.559 -9.191  -18.595 0.50 79.84  ? 440  ASN A OD1 1 
ATOM   1204 N  ND2 . ASN A 1 177 ? -36.598 -10.038 -16.800 0.50 77.83  ? 440  ASN A ND2 1 
ATOM   1205 N  N   . LEU A 1 178 ? -31.319 -9.384  -15.384 1.00 62.47  ? 441  LEU A N   1 
ATOM   1206 C  CA  . LEU A 1 178 ? -30.042 -8.865  -14.819 1.00 61.42  ? 441  LEU A CA  1 
ATOM   1207 C  C   . LEU A 1 178 ? -28.872 -9.170  -15.766 1.00 65.52  ? 441  LEU A C   1 
ATOM   1208 O  O   . LEU A 1 178 ? -28.055 -8.238  -16.011 1.00 65.74  ? 441  LEU A O   1 
ATOM   1209 C  CB  . LEU A 1 178 ? -29.810 -9.459  -13.430 1.00 65.94  ? 441  LEU A CB  1 
ATOM   1210 C  CG  . LEU A 1 178 ? -30.607 -8.797  -12.314 1.00 71.33  ? 441  LEU A CG  1 
ATOM   1211 C  CD1 . LEU A 1 178 ? -30.496 -9.595  -11.018 1.00 73.95  ? 441  LEU A CD1 1 
ATOM   1212 C  CD2 . LEU A 1 178 ? -30.139 -7.356  -12.120 1.00 75.94  ? 441  LEU A CD2 1 
ATOM   1213 N  N   . HIS A 1 179 ? -28.793 -10.375 -16.340 1.00 61.58  ? 442  HIS A N   1 
ATOM   1214 C  CA  . HIS A 1 179 ? -27.704 -10.710 -17.309 1.00 67.89  ? 442  HIS A CA  1 
ATOM   1215 C  C   . HIS A 1 179 ? -27.773 -9.800  -18.549 1.00 68.64  ? 442  HIS A C   1 
ATOM   1216 O  O   . HIS A 1 179 ? -26.697 -9.332  -18.982 1.00 70.20  ? 442  HIS A O   1 
ATOM   1217 C  CB  . HIS A 1 179 ? -27.716 -12.188 -17.714 1.00 67.28  ? 442  HIS A CB  1 
ATOM   1218 C  CG  . HIS A 1 179 ? -27.206 -13.107 -16.657 1.00 72.71  ? 442  HIS A CG  1 
ATOM   1219 N  ND1 . HIS A 1 179 ? -27.301 -14.480 -16.775 1.00 69.21  ? 442  HIS A ND1 1 
ATOM   1220 C  CD2 . HIS A 1 179 ? -26.625 -12.855 -15.461 1.00 68.67  ? 442  HIS A CD2 1 
ATOM   1221 C  CE1 . HIS A 1 179 ? -26.794 -15.032 -15.692 1.00 73.24  ? 442  HIS A CE1 1 
ATOM   1222 N  NE2 . HIS A 1 179 ? -26.356 -14.053 -14.875 1.00 66.40  ? 442  HIS A NE2 1 
ATOM   1223 N  N   . LEU A 1 180 ? -28.978 -9.542  -19.084 1.00 76.42  ? 443  LEU A N   1 
ATOM   1224 C  CA  . LEU A 1 180 ? -29.219 -8.617  -20.238 1.00 71.33  ? 443  LEU A CA  1 
ATOM   1225 C  C   . LEU A 1 180 ? -28.712 -7.197  -19.904 1.00 70.72  ? 443  LEU A C   1 
ATOM   1226 O  O   . LEU A 1 180 ? -28.272 -6.501  -20.805 1.00 67.48  ? 443  LEU A O   1 
ATOM   1227 C  CB  . LEU A 1 180 ? -30.703 -8.645  -20.637 1.00 66.16  ? 443  LEU A CB  1 
ATOM   1228 C  CG  . LEU A 1 180 ? -31.243 -9.992  -21.156 1.00 63.92  ? 443  LEU A CG  1 
ATOM   1229 C  CD1 . LEU A 1 180 ? -32.766 -10.074 -21.085 1.00 65.91  ? 443  LEU A CD1 1 
ATOM   1230 C  CD2 . LEU A 1 180 ? -30.805 -10.269 -22.586 1.00 64.26  ? 443  LEU A CD2 1 
ATOM   1231 N  N   . GLU A 1 181 ? -28.780 -6.834  -18.617 0.50 75.82  ? 444  GLU A N   1 
ATOM   1232 C  CA  . GLU A 1 181 ? -28.303 -5.560  -18.009 0.50 80.29  ? 444  GLU A CA  1 
ATOM   1233 C  C   . GLU A 1 181 ? -26.765 -5.528  -17.979 0.50 82.84  ? 444  GLU A C   1 
ATOM   1234 O  O   . GLU A 1 181 ? -26.201 -4.419  -17.859 0.50 86.81  ? 444  GLU A O   1 
ATOM   1235 C  CB  . GLU A 1 181 ? -28.876 -5.460  -16.590 0.50 81.12  ? 444  GLU A CB  1 
ATOM   1236 C  CG  . GLU A 1 181 ? -29.602 -4.163  -16.268 0.50 81.03  ? 444  GLU A CG  1 
ATOM   1237 C  CD  . GLU A 1 181 ? -30.501 -4.246  -15.039 0.50 79.71  ? 444  GLU A CD  1 
ATOM   1238 O  OE1 . GLU A 1 181 ? -30.209 -3.555  -14.033 0.50 74.38  ? 444  GLU A OE1 1 
ATOM   1239 O  OE2 . GLU A 1 181 ? -31.496 -5.003  -15.084 0.50 74.88  ? 444  GLU A OE2 1 
ATOM   1240 N  N   . GLY A 1 182 ? -26.116 -6.695  -18.087 1.00 85.64  ? 445  GLY A N   1 
ATOM   1241 C  CA  . GLY A 1 182 ? -24.653 -6.855  -17.919 1.00 70.69  ? 445  GLY A CA  1 
ATOM   1242 C  C   . GLY A 1 182 ? -24.255 -7.044  -16.460 1.00 60.33  ? 445  GLY A C   1 
ATOM   1243 O  O   . GLY A 1 182 ? -23.114 -6.724  -16.106 1.00 70.27  ? 445  GLY A O   1 
ATOM   1244 N  N   . LYS A 1 183 ? -25.147 -7.587  -15.642 1.00 52.56  ? 446  LYS A N   1 
ATOM   1245 C  CA  . LYS A 1 183 ? -24.975 -7.762  -14.179 1.00 58.37  ? 446  LYS A CA  1 
ATOM   1246 C  C   . LYS A 1 183 ? -25.427 -9.167  -13.751 1.00 50.42  ? 446  LYS A C   1 
ATOM   1247 O  O   . LYS A 1 183 ? -26.219 -9.789  -14.460 1.00 49.57  ? 446  LYS A O   1 
ATOM   1248 C  CB  . LYS A 1 183 ? -25.828 -6.739  -13.421 1.00 71.16  ? 446  LYS A CB  1 
ATOM   1249 C  CG  . LYS A 1 183 ? -25.686 -5.292  -13.871 1.00 79.38  ? 446  LYS A CG  1 
ATOM   1250 C  CD  . LYS A 1 183 ? -26.678 -4.390  -13.170 1.00 87.72  ? 446  LYS A CD  1 
ATOM   1251 C  CE  . LYS A 1 183 ? -26.638 -2.971  -13.684 1.00 99.75  ? 446  LYS A CE  1 
ATOM   1252 N  NZ  . LYS A 1 183 ? -27.759 -2.174  -13.134 1.00 112.41 ? 446  LYS A NZ  1 
ATOM   1253 N  N   . CYS A 1 184 ? -25.025 -9.599  -12.555 1.00 56.20  ? 447  CYS A N   1 
ATOM   1254 C  CA  . CYS A 1 184 ? -25.231 -10.966 -12.017 1.00 59.49  ? 447  CYS A CA  1 
ATOM   1255 C  C   . CYS A 1 184 ? -25.426 -10.886 -10.498 1.00 55.89  ? 447  CYS A C   1 
ATOM   1256 O  O   . CYS A 1 184 ? -24.638 -10.144 -9.862  1.00 58.18  ? 447  CYS A O   1 
ATOM   1257 C  CB  . CYS A 1 184 ? -24.015 -11.838 -12.364 1.00 65.12  ? 447  CYS A CB  1 
ATOM   1258 S  SG  . CYS A 1 184 ? -24.183 -13.577 -11.872 1.00 62.35  ? 447  CYS A SG  1 
ATOM   1259 N  N   . GLU A 1 185 ? -26.333 -11.694 -9.932  1.00 57.95  ? 448  GLU A N   1 
ATOM   1260 C  CA  . GLU A 1 185 ? -26.644 -11.682 -8.474  1.00 70.21  ? 448  GLU A CA  1 
ATOM   1261 C  C   . GLU A 1 185 ? -26.500 -13.070 -7.822  1.00 71.82  ? 448  GLU A C   1 
ATOM   1262 O  O   . GLU A 1 185 ? -26.105 -13.110 -6.632  1.00 72.53  ? 448  GLU A O   1 
ATOM   1263 C  CB  . GLU A 1 185 ? -28.056 -11.124 -8.250  1.00 82.51  ? 448  GLU A CB  1 
ATOM   1264 C  CG  . GLU A 1 185 ? -28.340 -10.698 -6.813  1.00 87.05  ? 448  GLU A CG  1 
ATOM   1265 C  CD  . GLU A 1 185 ? -29.774 -10.257 -6.528  1.00 101.63 ? 448  GLU A CD  1 
ATOM   1266 O  OE1 . GLU A 1 185 ? -30.186 -9.202  -7.067  1.00 99.40  ? 448  GLU A OE1 1 
ATOM   1267 O  OE2 . GLU A 1 185 ? -30.487 -10.971 -5.771  1.00 106.12 ? 448  GLU A OE2 1 
ATOM   1268 N  N   . THR A 1 186 ? -26.846 -14.170 -8.493  1.00 67.64  ? 449  THR A N   1 
ATOM   1269 C  CA  . THR A 1 186 ? -27.023 -15.481 -7.810  1.00 71.03  ? 449  THR A CA  1 
ATOM   1270 C  C   . THR A 1 186 ? -26.235 -16.619 -8.487  1.00 67.01  ? 449  THR A C   1 
ATOM   1271 O  O   . THR A 1 186 ? -26.425 -17.772 -8.070  1.00 76.26  ? 449  THR A O   1 
ATOM   1272 C  CB  . THR A 1 186 ? -28.515 -15.806 -7.685  1.00 73.19  ? 449  THR A CB  1 
ATOM   1273 O  OG1 . THR A 1 186 ? -29.018 -16.280 -8.928  1.00 74.33  ? 449  THR A OG1 1 
ATOM   1274 C  CG2 . THR A 1 186 ? -29.342 -14.609 -7.280  1.00 84.81  ? 449  THR A CG2 1 
ATOM   1275 N  N   . CYS A 1 187 ? -25.378 -16.333 -9.464  1.00 60.20  ? 450  CYS A N   1 
ATOM   1276 C  CA  . CYS A 1 187 ? -24.588 -17.357 -10.200 1.00 58.75  ? 450  CYS A CA  1 
ATOM   1277 C  C   . CYS A 1 187 ? -23.234 -17.532 -9.497  1.00 55.70  ? 450  CYS A C   1 
ATOM   1278 O  O   . CYS A 1 187 ? -22.215 -16.960 -9.938  1.00 49.27  ? 450  CYS A O   1 
ATOM   1279 C  CB  . CYS A 1 187 ? -24.482 -16.983 -11.672 1.00 57.03  ? 450  CYS A CB  1 
ATOM   1280 S  SG  . CYS A 1 187 ? -26.106 -16.646 -12.411 1.00 64.83  ? 450  CYS A SG  1 
ATOM   1281 N  N   . VAL A 1 188 ? -23.233 -18.309 -8.411  0.50 60.55  ? 451  VAL A N   1 
ATOM   1282 C  CA  . VAL A 1 188 ? -22.041 -18.562 -7.546  0.50 65.69  ? 451  VAL A CA  1 
ATOM   1283 C  C   . VAL A 1 188 ? -21.740 -20.066 -7.523  0.50 64.08  ? 451  VAL A C   1 
ATOM   1284 O  O   . VAL A 1 188 ? -22.692 -20.869 -7.476  0.50 62.82  ? 451  VAL A O   1 
ATOM   1285 C  CB  . VAL A 1 188 ? -22.257 -18.006 -6.127  0.50 69.35  ? 451  VAL A CB  1 
ATOM   1286 C  CG1 . VAL A 1 188 ? -21.137 -18.419 -5.182  0.50 73.29  ? 451  VAL A CG1 1 
ATOM   1287 C  CG2 . VAL A 1 188 ? -22.416 -16.493 -6.144  0.50 70.30  ? 451  VAL A CG2 1 
ATOM   1288 N  N   . TYR A 1 189 ? -20.454 -20.417 -7.548  1.00 64.97  ? 452  TYR A N   1 
ATOM   1289 C  CA  . TYR A 1 189 ? -19.975 -21.825 -7.593  1.00 73.27  ? 452  TYR A CA  1 
ATOM   1290 C  C   . TYR A 1 189 ? -19.824 -22.365 -6.167  1.00 74.62  ? 452  TYR A C   1 
ATOM   1291 O  O   . TYR A 1 189 ? -19.621 -21.567 -5.257  1.00 71.16  ? 452  TYR A O   1 
ATOM   1292 C  CB  . TYR A 1 189 ? -18.685 -21.869 -8.414  1.00 70.91  ? 452  TYR A CB  1 
ATOM   1293 C  CG  . TYR A 1 189 ? -18.924 -21.767 -9.899  1.00 71.18  ? 452  TYR A CG  1 
ATOM   1294 C  CD1 . TYR A 1 189 ? -19.648 -22.744 -10.565 1.00 74.68  ? 452  TYR A CD1 1 
ATOM   1295 C  CD2 . TYR A 1 189 ? -18.466 -20.683 -10.631 1.00 73.58  ? 452  TYR A CD2 1 
ATOM   1296 C  CE1 . TYR A 1 189 ? -19.903 -22.650 -11.922 1.00 81.21  ? 452  TYR A CE1 1 
ATOM   1297 C  CE2 . TYR A 1 189 ? -18.703 -20.576 -11.994 1.00 73.80  ? 452  TYR A CE2 1 
ATOM   1298 C  CZ  . TYR A 1 189 ? -19.432 -21.561 -12.638 1.00 79.24  ? 452  TYR A CZ  1 
ATOM   1299 O  OH  . TYR A 1 189 ? -19.694 -21.486 -13.973 1.00 90.85  ? 452  TYR A OH  1 
ATOM   1300 N  N   . ASN A 1 190 ? -19.958 -23.684 -5.987  1.00 89.28  ? 453  ASN A N   1 
ATOM   1301 C  CA  . ASN A 1 190 ? -19.719 -24.395 -4.699  1.00 88.85  ? 453  ASN A CA  1 
ATOM   1302 C  C   . ASN A 1 190 ? -18.695 -25.514 -4.889  1.00 89.14  ? 453  ASN A C   1 
ATOM   1303 O  O   . ASN A 1 190 ? -19.078 -26.529 -5.478  1.00 90.76  ? 453  ASN A O   1 
ATOM   1304 C  CB  . ASN A 1 190 ? -21.010 -24.979 -4.143  1.00 80.13  ? 453  ASN A CB  1 
ATOM   1305 C  CG  . ASN A 1 190 ? -22.055 -23.905 -3.968  1.00 76.82  ? 453  ASN A CG  1 
ATOM   1306 O  OD1 . ASN A 1 190 ? -21.995 -22.877 -4.628  1.00 87.36  ? 453  ASN A OD1 1 
ATOM   1307 N  ND2 . ASN A 1 190 ? -22.999 -24.122 -3.069  1.00 68.60  ? 453  ASN A ND2 1 
ATOM   1308 N  N   . MET A 1 191 ? -17.464 -25.329 -4.390  1.00 102.72 ? 454  MET A N   1 
ATOM   1309 C  CA  . MET A 1 191 ? -16.347 -26.307 -4.523  1.00 114.19 ? 454  MET A CA  1 
ATOM   1310 C  C   . MET A 1 191 ? -16.659 -27.539 -3.664  1.00 125.50 ? 454  MET A C   1 
ATOM   1311 O  O   . MET A 1 191 ? -17.534 -27.420 -2.781  1.00 129.83 ? 454  MET A O   1 
ATOM   1312 C  CB  . MET A 1 191 ? -15.010 -25.697 -4.091  1.00 115.33 ? 454  MET A CB  1 
ATOM   1313 C  CG  . MET A 1 191 ? -13.812 -26.510 -4.552  1.00 133.00 ? 454  MET A CG  1 
ATOM   1314 S  SD  . MET A 1 191 ? -12.217 -25.674 -4.365  1.00 163.07 ? 454  MET A SD  1 
ATOM   1315 C  CE  . MET A 1 191 ? -12.354 -24.393 -5.610  1.00 151.30 ? 454  MET A CE  1 
ATOM   1316 N  N   . MET A 1 192 ? -16.005 -28.678 -3.947  1.00 135.68 ? 455  MET A N   1 
ATOM   1317 C  CA  . MET A 1 192 ? -16.111 -29.952 -3.173  1.00 135.69 ? 455  MET A CA  1 
ATOM   1318 C  C   . MET A 1 192 ? -14.998 -30.924 -3.599  1.00 146.95 ? 455  MET A C   1 
ATOM   1319 O  O   . MET A 1 192 ? -15.009 -31.356 -4.772  1.00 157.18 ? 455  MET A O   1 
ATOM   1320 C  CB  . MET A 1 192 ? -17.483 -30.610 -3.377  1.00 126.93 ? 455  MET A CB  1 
ATOM   1321 C  CG  . MET A 1 192 ? -18.496 -30.266 -2.299  1.00 113.52 ? 455  MET A CG  1 
ATOM   1322 S  SD  . MET A 1 192 ? -20.131 -29.888 -2.969  1.00 116.65 ? 455  MET A SD  1 
ATOM   1323 C  CE  . MET A 1 192 ? -20.854 -31.529 -3.027  1.00 112.62 ? 455  MET A CE  1 
ATOM   1324 N  N   . ALA A 1 210 ? -12.417 -32.054 -8.581  1.00 156.12 ? 473  ALA A N   1 
ATOM   1325 C  CA  . ALA A 1 210 ? -13.090 -31.055 -7.708  1.00 146.22 ? 473  ALA A CA  1 
ATOM   1326 C  C   . ALA A 1 210 ? -14.191 -30.375 -8.547  1.00 130.13 ? 473  ALA A C   1 
ATOM   1327 O  O   . ALA A 1 210 ? -13.874 -29.483 -9.359  1.00 121.73 ? 473  ALA A O   1 
ATOM   1328 C  CB  . ALA A 1 210 ? -12.088 -30.060 -7.156  1.00 143.70 ? 473  ALA A CB  1 
ATOM   1329 N  N   . ILE A 1 211 ? -15.447 -30.795 -8.350  0.50 126.73 ? 474  ILE A N   1 
ATOM   1330 C  CA  . ILE A 1 211 ? -16.633 -30.357 -9.149  0.50 124.87 ? 474  ILE A CA  1 
ATOM   1331 C  C   . ILE A 1 211 ? -17.272 -29.133 -8.483  0.50 124.51 ? 474  ILE A C   1 
ATOM   1332 O  O   . ILE A 1 211 ? -17.501 -29.179 -7.257  0.50 124.82 ? 474  ILE A O   1 
ATOM   1333 C  CB  . ILE A 1 211 ? -17.646 -31.511 -9.298  0.50 121.93 ? 474  ILE A CB  1 
ATOM   1334 C  CG1 . ILE A 1 211 ? -16.958 -32.823 -9.684  0.50 121.22 ? 474  ILE A CG1 1 
ATOM   1335 C  CG2 . ILE A 1 211 ? -18.751 -31.141 -10.277 0.50 118.86 ? 474  ILE A CG2 1 
ATOM   1336 C  CD1 . ILE A 1 211 ? -16.154 -33.450 -8.566  0.50 119.70 ? 474  ILE A CD1 1 
ATOM   1337 N  N   . TRP A 1 212 ? -17.542 -28.084 -9.265  0.50 121.23 ? 475  TRP A N   1 
ATOM   1338 C  CA  . TRP A 1 212 ? -18.210 -26.873 -8.720  0.50 117.02 ? 475  TRP A CA  1 
ATOM   1339 C  C   . TRP A 1 212 ? -19.694 -26.913 -9.091  0.50 113.54 ? 475  TRP A C   1 
ATOM   1340 O  O   . TRP A 1 212 ? -20.010 -26.728 -10.279 0.50 114.39 ? 475  TRP A O   1 
ATOM   1341 C  CB  . TRP A 1 212 ? -17.537 -25.597 -9.237  0.50 115.68 ? 475  TRP A CB  1 
ATOM   1342 C  CG  . TRP A 1 212 ? -16.073 -25.513 -8.940  0.50 114.76 ? 475  TRP A CG  1 
ATOM   1343 C  CD1 . TRP A 1 212 ? -15.362 -26.282 -8.065  0.50 115.20 ? 475  TRP A CD1 1 
ATOM   1344 C  CD2 . TRP A 1 212 ? -15.132 -24.592 -9.519  0.50 112.89 ? 475  TRP A CD2 1 
ATOM   1345 N  NE1 . TRP A 1 212 ? -14.046 -25.907 -8.064  0.50 115.52 ? 475  TRP A NE1 1 
ATOM   1346 C  CE2 . TRP A 1 212 ? -13.875 -24.873 -8.946  0.50 112.26 ? 475  TRP A CE2 1 
ATOM   1347 C  CE3 . TRP A 1 212 ? -15.230 -23.563 -10.461 0.50 111.17 ? 475  TRP A CE3 1 
ATOM   1348 C  CZ2 . TRP A 1 212 ? -12.727 -24.161 -9.288  0.50 110.61 ? 475  TRP A CZ2 1 
ATOM   1349 C  CZ3 . TRP A 1 212 ? -14.095 -22.862 -10.800 0.50 112.19 ? 475  TRP A CZ3 1 
ATOM   1350 C  CH2 . TRP A 1 212 ? -12.862 -23.159 -10.221 0.50 112.25 ? 475  TRP A CH2 1 
ATOM   1351 N  N   . TYR A 1 213 ? -20.561 -27.154 -8.108  0.50 109.95 ? 476  TYR A N   1 
ATOM   1352 C  CA  . TYR A 1 213 ? -22.023 -27.189 -8.363  0.50 108.97 ? 476  TYR A CA  1 
ATOM   1353 C  C   . TYR A 1 213 ? -22.580 -25.765 -8.400  0.50 101.85 ? 476  TYR A C   1 
ATOM   1354 O  O   . TYR A 1 213 ? -21.900 -24.844 -7.914  0.50 97.21  ? 476  TYR A O   1 
ATOM   1355 C  CB  . TYR A 1 213 ? -22.731 -28.014 -7.287  0.50 113.75 ? 476  TYR A CB  1 
ATOM   1356 C  CG  . TYR A 1 213 ? -22.321 -29.463 -7.229  0.50 120.00 ? 476  TYR A CG  1 
ATOM   1357 C  CD1 . TYR A 1 213 ? -23.090 -30.446 -7.828  0.50 124.42 ? 476  TYR A CD1 1 
ATOM   1358 C  CD2 . TYR A 1 213 ? -21.166 -29.855 -6.573  0.50 124.19 ? 476  TYR A CD2 1 
ATOM   1359 C  CE1 . TYR A 1 213 ? -22.723 -31.780 -7.780  0.50 126.79 ? 476  TYR A CE1 1 
ATOM   1360 C  CE2 . TYR A 1 213 ? -20.784 -31.185 -6.515  0.50 127.06 ? 476  TYR A CE2 1 
ATOM   1361 C  CZ  . TYR A 1 213 ? -21.566 -32.152 -7.121  0.50 128.82 ? 476  TYR A CZ  1 
ATOM   1362 O  OH  . TYR A 1 213 ? -21.198 -33.465 -7.070  0.50 129.63 ? 476  TYR A OH  1 
ATOM   1363 N  N   . MET A 1 214 ? -23.774 -25.593 -8.973  0.50 94.76  ? 477  MET A N   1 
ATOM   1364 C  CA  . MET A 1 214 ? -24.441 -24.266 -8.990  0.50 91.29  ? 477  MET A CA  1 
ATOM   1365 C  C   . MET A 1 214 ? -25.934 -24.498 -8.767  0.50 87.53  ? 477  MET A C   1 
ATOM   1366 O  O   . MET A 1 214 ? -26.371 -25.649 -8.923  0.50 90.13  ? 477  MET A O   1 
ATOM   1367 C  CB  . MET A 1 214 ? -24.237 -23.557 -10.331 0.50 92.43  ? 477  MET A CB  1 
ATOM   1368 C  CG  . MET A 1 214 ? -23.301 -22.370 -10.267 0.50 93.26  ? 477  MET A CG  1 
ATOM   1369 S  SD  . MET A 1 214 ? -23.175 -21.553 -11.876 0.50 96.96  ? 477  MET A SD  1 
ATOM   1370 C  CE  . MET A 1 214 ? -22.230 -20.097 -11.435 0.50 92.84  ? 477  MET A CE  1 
ATOM   1371 N  N   . TRP A 1 215 ? -26.685 -23.451 -8.424  0.50 87.04  ? 478  TRP A N   1 
ATOM   1372 C  CA  . TRP A 1 215 ? -28.156 -23.613 -8.283  0.50 89.81  ? 478  TRP A CA  1 
ATOM   1373 C  C   . TRP A 1 215 ? -28.765 -23.918 -9.657  0.50 86.66  ? 478  TRP A C   1 
ATOM   1374 O  O   . TRP A 1 215 ? -28.246 -23.394 -10.656 0.50 87.53  ? 478  TRP A O   1 
ATOM   1375 C  CB  . TRP A 1 215 ? -28.790 -22.404 -7.581  0.50 94.65  ? 478  TRP A CB  1 
ATOM   1376 C  CG  . TRP A 1 215 ? -29.088 -21.211 -8.433  0.50 101.29 ? 478  TRP A CG  1 
ATOM   1377 C  CD1 . TRP A 1 215 ? -28.193 -20.377 -9.037  0.50 106.99 ? 478  TRP A CD1 1 
ATOM   1378 C  CD2 . TRP A 1 215 ? -30.391 -20.678 -8.724  0.50 104.87 ? 478  TRP A CD2 1 
ATOM   1379 N  NE1 . TRP A 1 215 ? -28.850 -19.380 -9.706  0.50 110.64 ? 478  TRP A NE1 1 
ATOM   1380 C  CE2 . TRP A 1 215 ? -30.200 -19.538 -9.531  0.50 109.31 ? 478  TRP A CE2 1 
ATOM   1381 C  CE3 . TRP A 1 215 ? -31.696 -21.061 -8.395  0.50 103.67 ? 478  TRP A CE3 1 
ATOM   1382 C  CZ2 . TRP A 1 215 ? -31.266 -18.780 -10.011 0.50 105.84 ? 478  TRP A CZ2 1 
ATOM   1383 C  CZ3 . TRP A 1 215 ? -32.749 -20.312 -8.870  0.50 104.77 ? 478  TRP A CZ3 1 
ATOM   1384 C  CH2 . TRP A 1 215 ? -32.534 -19.187 -9.667  0.50 104.72 ? 478  TRP A CH2 1 
ATOM   1385 N  N   . LEU A 1 216 ? -29.821 -24.733 -9.699  0.50 82.67  ? 479  LEU A N   1 
ATOM   1386 C  CA  . LEU A 1 216 ? -30.412 -25.176 -10.991 0.50 82.62  ? 479  LEU A CA  1 
ATOM   1387 C  C   . LEU A 1 216 ? -30.658 -23.983 -11.919 0.50 82.14  ? 479  LEU A C   1 
ATOM   1388 O  O   . LEU A 1 216 ? -30.431 -24.135 -13.128 0.50 86.68  ? 479  LEU A O   1 
ATOM   1389 C  CB  . LEU A 1 216 ? -31.723 -25.911 -10.700 0.50 81.48  ? 479  LEU A CB  1 
ATOM   1390 C  CG  . LEU A 1 216 ? -32.244 -26.791 -11.833 0.50 83.82  ? 479  LEU A CG  1 
ATOM   1391 C  CD1 . LEU A 1 216 ? -31.271 -27.924 -12.119 0.50 83.98  ? 479  LEU A CD1 1 
ATOM   1392 C  CD2 . LEU A 1 216 ? -33.620 -27.344 -11.501 0.50 84.93  ? 479  LEU A CD2 1 
ATOM   1393 N  N   . GLY A 1 217 ? -31.111 -22.851 -11.381 0.50 77.35  ? 480  GLY A N   1 
ATOM   1394 C  CA  . GLY A 1 217 ? -31.448 -21.705 -12.243 0.50 72.21  ? 480  GLY A CA  1 
ATOM   1395 C  C   . GLY A 1 217 ? -30.249 -21.258 -13.049 0.50 70.74  ? 480  GLY A C   1 
ATOM   1396 O  O   . GLY A 1 217 ? -30.413 -20.977 -14.246 0.50 71.96  ? 480  GLY A O   1 
ATOM   1397 N  N   . ALA A 1 218 ? -29.084 -21.198 -12.409 1.00 68.44  ? 481  ALA A N   1 
ATOM   1398 C  CA  . ALA A 1 218 ? -27.840 -20.792 -13.101 1.00 66.02  ? 481  ALA A CA  1 
ATOM   1399 C  C   . ALA A 1 218 ? -27.444 -21.859 -14.121 1.00 61.93  ? 481  ALA A C   1 
ATOM   1400 O  O   . ALA A 1 218 ? -26.939 -21.485 -15.184 1.00 58.96  ? 481  ALA A O   1 
ATOM   1401 C  CB  . ALA A 1 218 ? -26.756 -20.567 -12.090 1.00 60.55  ? 481  ALA A CB  1 
ATOM   1402 N  N   . ARG A 1 219 ? -27.668 -23.132 -13.794 0.50 61.88  ? 482  ARG A N   1 
ATOM   1403 C  CA  . ARG A 1 219 ? -27.387 -24.227 -14.756 0.50 64.34  ? 482  ARG A CA  1 
ATOM   1404 C  C   . ARG A 1 219 ? -28.274 -24.036 -15.988 0.50 60.92  ? 482  ARG A C   1 
ATOM   1405 O  O   . ARG A 1 219 ? -27.792 -24.286 -17.103 0.50 59.97  ? 482  ARG A O   1 
ATOM   1406 C  CB  . ARG A 1 219 ? -27.633 -25.585 -14.098 0.50 68.20  ? 482  ARG A CB  1 
ATOM   1407 C  CG  . ARG A 1 219 ? -26.360 -26.292 -13.655 0.50 76.72  ? 482  ARG A CG  1 
ATOM   1408 C  CD  . ARG A 1 219 ? -25.556 -25.433 -12.701 0.50 81.85  ? 482  ARG A CD  1 
ATOM   1409 N  NE  . ARG A 1 219 ? -24.261 -26.009 -12.371 0.50 86.05  ? 482  ARG A NE  1 
ATOM   1410 C  CZ  . ARG A 1 219 ? -23.137 -25.753 -13.028 0.50 88.95  ? 482  ARG A CZ  1 
ATOM   1411 N  NH1 . ARG A 1 219 ? -23.147 -24.927 -14.059 0.50 92.72  ? 482  ARG A NH1 1 
ATOM   1412 N  NH2 . ARG A 1 219 ? -22.007 -26.322 -12.651 0.50 92.74  ? 482  ARG A NH2 1 
ATOM   1413 N  N   . PHE A 1 220 ? -29.517 -23.598 -15.782 1.00 56.77  ? 483  PHE A N   1 
ATOM   1414 C  CA  . PHE A 1 220 ? -30.440 -23.351 -16.915 1.00 51.43  ? 483  PHE A CA  1 
ATOM   1415 C  C   . PHE A 1 220 ? -29.893 -22.239 -17.793 1.00 48.13  ? 483  PHE A C   1 
ATOM   1416 O  O   . PHE A 1 220 ? -29.882 -22.391 -19.013 1.00 50.88  ? 483  PHE A O   1 
ATOM   1417 C  CB  . PHE A 1 220 ? -31.818 -22.898 -16.439 1.00 54.25  ? 483  PHE A CB  1 
ATOM   1418 C  CG  . PHE A 1 220 ? -32.721 -22.474 -17.566 1.00 47.66  ? 483  PHE A CG  1 
ATOM   1419 C  CD1 . PHE A 1 220 ? -33.326 -23.418 -18.378 1.00 50.31  ? 483  PHE A CD1 1 
ATOM   1420 C  CD2 . PHE A 1 220 ? -32.940 -21.135 -17.835 1.00 49.20  ? 483  PHE A CD2 1 
ATOM   1421 C  CE1 . PHE A 1 220 ? -34.142 -23.030 -19.426 1.00 60.22  ? 483  PHE A CE1 1 
ATOM   1422 C  CE2 . PHE A 1 220 ? -33.757 -20.748 -18.884 1.00 50.29  ? 483  PHE A CE2 1 
ATOM   1423 C  CZ  . PHE A 1 220 ? -34.357 -21.696 -19.676 1.00 53.07  ? 483  PHE A CZ  1 
ATOM   1424 N  N   . LEU A 1 221 ? -29.471 -21.148 -17.171 1.00 51.67  ? 484  LEU A N   1 
ATOM   1425 C  CA  . LEU A 1 221 ? -29.003 -19.976 -17.947 1.00 52.91  ? 484  LEU A CA  1 
ATOM   1426 C  C   . LEU A 1 221 ? -27.761 -20.362 -18.748 1.00 51.65  ? 484  LEU A C   1 
ATOM   1427 O  O   . LEU A 1 221 ? -27.618 -19.860 -19.866 1.00 50.07  ? 484  LEU A O   1 
ATOM   1428 C  CB  . LEU A 1 221 ? -28.745 -18.827 -16.973 1.00 56.73  ? 484  LEU A CB  1 
ATOM   1429 C  CG  . LEU A 1 221 ? -29.995 -18.151 -16.414 1.00 61.19  ? 484  LEU A CG  1 
ATOM   1430 C  CD1 . LEU A 1 221 ? -29.624 -16.975 -15.526 1.00 62.17  ? 484  LEU A CD1 1 
ATOM   1431 C  CD2 . LEU A 1 221 ? -30.905 -17.689 -17.539 1.00 62.73  ? 484  LEU A CD2 1 
ATOM   1432 N  N   . GLU A 1 222 ? -26.910 -21.226 -18.194 0.50 51.55  ? 485  GLU A N   1 
ATOM   1433 C  CA  . GLU A 1 222 ? -25.731 -21.722 -18.949 0.50 50.54  ? 485  GLU A CA  1 
ATOM   1434 C  C   . GLU A 1 222 ? -26.220 -22.610 -20.099 0.50 47.38  ? 485  GLU A C   1 
ATOM   1435 O  O   . GLU A 1 222 ? -25.713 -22.443 -21.217 0.50 47.60  ? 485  GLU A O   1 
ATOM   1436 C  CB  . GLU A 1 222 ? -24.806 -22.468 -17.986 0.50 52.04  ? 485  GLU A CB  1 
ATOM   1437 C  CG  . GLU A 1 222 ? -23.669 -23.207 -18.660 0.50 54.18  ? 485  GLU A CG  1 
ATOM   1438 C  CD  . GLU A 1 222 ? -22.907 -24.114 -17.711 0.50 54.02  ? 485  GLU A CD  1 
ATOM   1439 O  OE1 . GLU A 1 222 ? -21.819 -23.715 -17.261 0.50 53.90  ? 485  GLU A OE1 1 
ATOM   1440 O  OE2 . GLU A 1 222 ? -23.410 -25.214 -17.419 0.50 54.40  ? 485  GLU A OE2 1 
ATOM   1441 N  N   . PHE A 1 223 ? -27.181 -23.497 -19.832 1.00 46.57  ? 486  PHE A N   1 
ATOM   1442 C  CA  . PHE A 1 223 ? -27.722 -24.434 -20.852 1.00 48.37  ? 486  PHE A CA  1 
ATOM   1443 C  C   . PHE A 1 223 ? -28.464 -23.652 -21.931 1.00 50.82  ? 486  PHE A C   1 
ATOM   1444 O  O   . PHE A 1 223 ? -28.347 -24.003 -23.106 1.00 46.51  ? 486  PHE A O   1 
ATOM   1445 C  CB  . PHE A 1 223 ? -28.651 -25.439 -20.173 1.00 50.47  ? 486  PHE A CB  1 
ATOM   1446 C  CG  . PHE A 1 223 ? -29.494 -26.292 -21.085 1.00 50.01  ? 486  PHE A CG  1 
ATOM   1447 C  CD1 . PHE A 1 223 ? -28.949 -27.377 -21.749 1.00 49.50  ? 486  PHE A CD1 1 
ATOM   1448 C  CD2 . PHE A 1 223 ? -30.842 -26.027 -21.253 1.00 49.31  ? 486  PHE A CD2 1 
ATOM   1449 C  CE1 . PHE A 1 223 ? -29.729 -28.165 -22.578 1.00 53.24  ? 486  PHE A CE1 1 
ATOM   1450 C  CE2 . PHE A 1 223 ? -31.623 -26.818 -22.080 1.00 47.01  ? 486  PHE A CE2 1 
ATOM   1451 C  CZ  . PHE A 1 223 ? -31.064 -27.885 -22.741 1.00 48.10  ? 486  PHE A CZ  1 
ATOM   1452 N  N   . GLU A 1 224 ? -29.210 -22.633 -21.522 0.50 51.86  ? 487  GLU A N   1 
ATOM   1453 C  CA  . GLU A 1 224 ? -29.955 -21.761 -22.474 0.50 52.60  ? 487  GLU A CA  1 
ATOM   1454 C  C   . GLU A 1 224 ? -28.973 -21.134 -23.472 0.50 49.44  ? 487  GLU A C   1 
ATOM   1455 O  O   . GLU A 1 224 ? -29.255 -21.160 -24.687 0.50 47.78  ? 487  GLU A O   1 
ATOM   1456 C  CB  . GLU A 1 224 ? -30.712 -20.672 -21.707 0.50 56.53  ? 487  GLU A CB  1 
ATOM   1457 C  CG  . GLU A 1 224 ? -31.400 -19.655 -22.601 0.50 58.95  ? 487  GLU A CG  1 
ATOM   1458 C  CD  . GLU A 1 224 ? -32.275 -18.639 -21.875 0.50 61.06  ? 487  GLU A CD  1 
ATOM   1459 O  OE1 . GLU A 1 224 ? -33.219 -18.119 -22.508 0.50 57.78  ? 487  GLU A OE1 1 
ATOM   1460 O  OE2 . GLU A 1 224 ? -32.005 -18.359 -20.682 0.50 59.72  ? 487  GLU A OE2 1 
ATOM   1461 N  N   . ALA A 1 225 ? -27.857 -20.603 -22.973 1.00 44.03  ? 488  ALA A N   1 
ATOM   1462 C  CA  . ALA A 1 225 ? -26.893 -19.850 -23.792 1.00 44.89  ? 488  ALA A CA  1 
ATOM   1463 C  C   . ALA A 1 225 ? -25.955 -20.784 -24.555 1.00 43.00  ? 488  ALA A C   1 
ATOM   1464 O  O   . ALA A 1 225 ? -25.579 -20.386 -25.678 1.00 45.02  ? 488  ALA A O   1 
ATOM   1465 C  CB  . ALA A 1 225 ? -26.167 -18.884 -22.906 1.00 44.28  ? 488  ALA A CB  1 
ATOM   1466 N  N   . LEU A 1 226 ? -25.552 -21.939 -23.990 1.00 44.30  ? 489  LEU A N   1 
ATOM   1467 C  CA  . LEU A 1 226 ? -24.394 -22.733 -24.524 1.00 39.41  ? 489  LEU A CA  1 
ATOM   1468 C  C   . LEU A 1 226 ? -24.713 -24.218 -24.722 1.00 37.39  ? 489  LEU A C   1 
ATOM   1469 O  O   . LEU A 1 226 ? -23.861 -24.929 -25.354 1.00 39.68  ? 489  LEU A O   1 
ATOM   1470 C  CB  . LEU A 1 226 ? -23.188 -22.533 -23.601 1.00 37.78  ? 489  LEU A CB  1 
ATOM   1471 C  CG  . LEU A 1 226 ? -22.751 -21.083 -23.451 1.00 40.75  ? 489  LEU A CG  1 
ATOM   1472 C  CD1 . LEU A 1 226 ? -21.610 -20.917 -22.431 1.00 44.19  ? 489  LEU A CD1 1 
ATOM   1473 C  CD2 . LEU A 1 226 ? -22.312 -20.540 -24.794 1.00 45.14  ? 489  LEU A CD2 1 
ATOM   1474 N  N   . GLY A 1 227 ? -25.880 -24.690 -24.272 1.00 34.09  ? 490  GLY A N   1 
ATOM   1475 C  CA  . GLY A 1 227 ? -26.313 -26.096 -24.420 1.00 32.43  ? 490  GLY A CA  1 
ATOM   1476 C  C   . GLY A 1 227 ? -26.273 -26.538 -25.869 1.00 33.18  ? 490  GLY A C   1 
ATOM   1477 O  O   . GLY A 1 227 ? -26.098 -27.744 -26.143 1.00 35.77  ? 490  GLY A O   1 
ATOM   1478 N  N   . PHE A 1 228 ? -26.423 -25.607 -26.810 1.00 35.17  ? 491  PHE A N   1 
ATOM   1479 C  CA  . PHE A 1 228 ? -26.443 -25.972 -28.250 1.00 36.02  ? 491  PHE A CA  1 
ATOM   1480 C  C   . PHE A 1 228 ? -25.157 -26.738 -28.601 1.00 34.84  ? 491  PHE A C   1 
ATOM   1481 O  O   . PHE A 1 228 ? -25.242 -27.567 -29.498 1.00 36.26  ? 491  PHE A O   1 
ATOM   1482 C  CB  . PHE A 1 228 ? -26.666 -24.760 -29.169 1.00 35.59  ? 491  PHE A CB  1 
ATOM   1483 C  CG  . PHE A 1 228 ? -25.528 -23.798 -29.281 1.00 32.37  ? 491  PHE A CG  1 
ATOM   1484 C  CD1 . PHE A 1 228 ? -25.358 -22.794 -28.352 1.00 36.29  ? 491  PHE A CD1 1 
ATOM   1485 C  CD2 . PHE A 1 228 ? -24.574 -23.948 -30.272 1.00 34.72  ? 491  PHE A CD2 1 
ATOM   1486 C  CE1 . PHE A 1 228 ? -24.283 -21.922 -28.435 1.00 37.10  ? 491  PHE A CE1 1 
ATOM   1487 C  CE2 . PHE A 1 228 ? -23.485 -23.095 -30.340 1.00 33.48  ? 491  PHE A CE2 1 
ATOM   1488 C  CZ  . PHE A 1 228 ? -23.315 -22.107 -29.399 1.00 35.54  ? 491  PHE A CZ  1 
ATOM   1489 N  N   . LEU A 1 229 ? -24.012 -26.412 -27.992 1.00 38.16  ? 492  LEU A N   1 
ATOM   1490 C  CA  . LEU A 1 229 ? -22.695 -27.031 -28.356 1.00 39.87  ? 492  LEU A CA  1 
ATOM   1491 C  C   . LEU A 1 229 ? -22.819 -28.559 -28.239 1.00 37.01  ? 492  LEU A C   1 
ATOM   1492 O  O   . LEU A 1 229 ? -22.396 -29.324 -29.185 1.00 36.97  ? 492  LEU A O   1 
ATOM   1493 C  CB  . LEU A 1 229 ? -21.595 -26.473 -27.443 1.00 41.44  ? 492  LEU A CB  1 
ATOM   1494 C  CG  . LEU A 1 229 ? -21.175 -25.025 -27.697 1.00 39.72  ? 492  LEU A CG  1 
ATOM   1495 C  CD1 . LEU A 1 229 ? -20.302 -24.516 -26.571 1.00 41.30  ? 492  LEU A CD1 1 
ATOM   1496 C  CD2 . LEU A 1 229 ? -20.482 -24.876 -29.046 1.00 37.45  ? 492  LEU A CD2 1 
ATOM   1497 N  N   . ASN A 1 230 ? -23.421 -29.000 -27.140 1.00 36.07  ? 493  ASN A N   1 
ATOM   1498 C  CA  . ASN A 1 230 ? -23.634 -30.440 -26.878 1.00 40.98  ? 493  ASN A CA  1 
ATOM   1499 C  C   . ASN A 1 230 ? -24.915 -30.913 -27.568 1.00 39.44  ? 493  ASN A C   1 
ATOM   1500 O  O   . ASN A 1 230 ? -24.842 -31.941 -28.303 1.00 39.79  ? 493  ASN A O   1 
ATOM   1501 C  CB  . ASN A 1 230 ? -23.666 -30.745 -25.378 1.00 48.59  ? 493  ASN A CB  1 
ATOM   1502 C  CG  . ASN A 1 230 ? -23.864 -32.236 -25.146 1.00 60.99  ? 493  ASN A CG  1 
ATOM   1503 O  OD1 . ASN A 1 230 ? -24.908 -32.681 -24.636 1.00 61.08  ? 493  ASN A OD1 1 
ATOM   1504 N  ND2 . ASN A 1 230 ? -22.880 -33.024 -25.568 1.00 51.20  ? 493  ASN A ND2 1 
ATOM   1505 N  N   . GLU A 1 231 ? -26.055 -30.217 -27.359 1.00 42.17  ? 494  GLU A N   1 
ATOM   1506 C  CA  . GLU A 1 231 ? -27.391 -30.698 -27.846 1.00 40.23  ? 494  GLU A CA  1 
ATOM   1507 C  C   . GLU A 1 231 ? -27.384 -30.881 -29.379 1.00 38.27  ? 494  GLU A C   1 
ATOM   1508 O  O   . GLU A 1 231 ? -28.094 -31.780 -29.842 1.00 36.99  ? 494  GLU A O   1 
ATOM   1509 C  CB  . GLU A 1 231 ? -28.516 -29.728 -27.469 1.00 41.30  ? 494  GLU A CB  1 
ATOM   1510 C  CG  . GLU A 1 231 ? -28.857 -29.698 -26.002 1.00 42.21  ? 494  GLU A CG  1 
ATOM   1511 C  CD  . GLU A 1 231 ? -29.211 -31.064 -25.448 1.00 53.05  ? 494  GLU A CD  1 
ATOM   1512 O  OE1 . GLU A 1 231 ? -30.144 -31.711 -26.029 1.00 52.69  ? 494  GLU A OE1 1 
ATOM   1513 O  OE2 . GLU A 1 231 ? -28.496 -31.513 -24.493 1.00 56.92  ? 494  GLU A OE2 1 
ATOM   1514 N  N   . ASP A 1 232 ? -26.615 -30.065 -30.124 1.00 33.48  ? 495  ASP A N   1 
ATOM   1515 C  CA  . ASP A 1 232 ? -26.556 -30.078 -31.606 1.00 32.36  ? 495  ASP A CA  1 
ATOM   1516 C  C   . ASP A 1 232 ? -25.185 -30.588 -32.087 1.00 34.23  ? 495  ASP A C   1 
ATOM   1517 O  O   . ASP A 1 232 ? -24.902 -30.497 -33.300 1.00 33.49  ? 495  ASP A O   1 
ATOM   1518 C  CB  . ASP A 1 232 ? -26.878 -28.682 -32.149 1.00 40.00  ? 495  ASP A CB  1 
ATOM   1519 C  CG  . ASP A 1 232 ? -28.231 -28.142 -31.688 1.00 38.67  ? 495  ASP A CG  1 
ATOM   1520 O  OD1 . ASP A 1 232 ? -29.019 -28.942 -31.204 1.00 42.18  ? 495  ASP A OD1 1 
ATOM   1521 O  OD2 . ASP A 1 232 ? -28.448 -26.925 -31.779 1.00 39.69  ? 495  ASP A OD2 1 
ATOM   1522 N  N   . HIS A 1 233 ? -24.411 -31.228 -31.212 1.00 33.78  ? 496  HIS A N   1 
ATOM   1523 C  CA  . HIS A 1 233 ? -23.297 -32.112 -31.639 1.00 37.27  ? 496  HIS A CA  1 
ATOM   1524 C  C   . HIS A 1 233 ? -22.257 -31.307 -32.436 1.00 32.06  ? 496  HIS A C   1 
ATOM   1525 O  O   . HIS A 1 233 ? -21.856 -31.728 -33.510 1.00 34.70  ? 496  HIS A O   1 
ATOM   1526 C  CB  . HIS A 1 233 ? -23.858 -33.284 -32.447 1.00 40.52  ? 496  HIS A CB  1 
ATOM   1527 C  CG  . HIS A 1 233 ? -24.907 -34.044 -31.720 1.00 47.26  ? 496  HIS A CG  1 
ATOM   1528 N  ND1 . HIS A 1 233 ? -24.831 -34.286 -30.365 1.00 59.76  ? 496  HIS A ND1 1 
ATOM   1529 C  CD2 . HIS A 1 233 ? -26.101 -34.527 -32.114 1.00 51.83  ? 496  HIS A CD2 1 
ATOM   1530 C  CE1 . HIS A 1 233 ? -25.928 -34.918 -29.968 1.00 55.67  ? 496  HIS A CE1 1 
ATOM   1531 N  NE2 . HIS A 1 233 ? -26.699 -35.091 -31.023 1.00 47.31  ? 496  HIS A NE2 1 
ATOM   1532 N  N   . TRP A 1 234 ? -21.798 -30.190 -31.899 1.00 31.60  ? 497  TRP A N   1 
ATOM   1533 C  CA  . TRP A 1 234 ? -20.779 -29.329 -32.582 1.00 33.61  ? 497  TRP A CA  1 
ATOM   1534 C  C   . TRP A 1 234 ? -19.448 -30.085 -32.702 1.00 33.35  ? 497  TRP A C   1 
ATOM   1535 O  O   . TRP A 1 234 ? -18.701 -29.865 -33.689 1.00 35.21  ? 497  TRP A O   1 
ATOM   1536 C  CB  . TRP A 1 234 ? -20.638 -27.967 -31.876 1.00 31.95  ? 497  TRP A CB  1 
ATOM   1537 C  CG  . TRP A 1 234 ? -21.678 -26.987 -32.335 1.00 41.16  ? 497  TRP A CG  1 
ATOM   1538 C  CD1 . TRP A 1 234 ? -23.029 -27.210 -32.347 1.00 40.00  ? 497  TRP A CD1 1 
ATOM   1539 C  CD2 . TRP A 1 234 ? -21.489 -25.676 -32.895 1.00 41.61  ? 497  TRP A CD2 1 
ATOM   1540 N  NE1 . TRP A 1 234 ? -23.677 -26.141 -32.887 1.00 43.26  ? 497  TRP A NE1 1 
ATOM   1541 C  CE2 . TRP A 1 234 ? -22.775 -25.174 -33.211 1.00 47.22  ? 497  TRP A CE2 1 
ATOM   1542 C  CE3 . TRP A 1 234 ? -20.383 -24.850 -33.120 1.00 44.51  ? 497  TRP A CE3 1 
ATOM   1543 C  CZ2 . TRP A 1 234 ? -22.988 -23.895 -33.732 1.00 44.93  ? 497  TRP A CZ2 1 
ATOM   1544 C  CZ3 . TRP A 1 234 ? -20.589 -23.600 -33.669 1.00 46.49  ? 497  TRP A CZ3 1 
ATOM   1545 C  CH2 . TRP A 1 234 ? -21.873 -23.123 -33.957 1.00 43.35  ? 497  TRP A CH2 1 
ATOM   1546 N  N   . PHE A 1 235 ? -19.163 -30.957 -31.728 0.50 34.22  ? 498  PHE A N   1 
ATOM   1547 C  CA  . PHE A 1 235 ? -17.884 -31.702 -31.600 0.50 34.25  ? 498  PHE A CA  1 
ATOM   1548 C  C   . PHE A 1 235 ? -18.059 -33.166 -32.021 0.50 33.68  ? 498  PHE A C   1 
ATOM   1549 O  O   . PHE A 1 235 ? -17.198 -33.998 -31.675 0.50 35.92  ? 498  PHE A O   1 
ATOM   1550 C  CB  . PHE A 1 235 ? -17.351 -31.476 -30.189 0.50 34.51  ? 498  PHE A CB  1 
ATOM   1551 C  CG  . PHE A 1 235 ? -17.045 -30.021 -29.964 0.50 35.53  ? 498  PHE A CG  1 
ATOM   1552 C  CD1 . PHE A 1 235 ? -15.967 -29.428 -30.602 0.50 35.60  ? 498  PHE A CD1 1 
ATOM   1553 C  CD2 . PHE A 1 235 ? -17.875 -29.230 -29.189 0.50 35.10  ? 498  PHE A CD2 1 
ATOM   1554 C  CE1 . PHE A 1 235 ? -15.706 -28.077 -30.439 0.50 36.86  ? 498  PHE A CE1 1 
ATOM   1555 C  CE2 . PHE A 1 235 ? -17.606 -27.880 -29.021 0.50 34.86  ? 498  PHE A CE2 1 
ATOM   1556 C  CZ  . PHE A 1 235 ? -16.529 -27.305 -29.650 0.50 35.53  ? 498  PHE A CZ  1 
ATOM   1557 N  N   . SER A 1 236 ? -19.115 -33.462 -32.782 0.50 32.92  ? 499  SER A N   1 
ATOM   1558 C  CA  . SER A 1 236 ? -19.268 -34.715 -33.564 0.50 33.01  ? 499  SER A CA  1 
ATOM   1559 C  C   . SER A 1 236 ? -18.016 -34.907 -34.424 0.50 34.05  ? 499  SER A C   1 
ATOM   1560 O  O   . SER A 1 236 ? -17.387 -33.885 -34.750 0.50 35.08  ? 499  SER A O   1 
ATOM   1561 C  CB  . SER A 1 236 ? -20.488 -34.635 -34.437 0.50 32.82  ? 499  SER A CB  1 
ATOM   1562 O  OG  . SER A 1 236 ? -20.440 -33.468 -35.251 0.50 29.53  ? 499  SER A OG  1 
ATOM   1563 N  N   . ARG A 1 237 ? -17.688 -36.144 -34.818 1.00 35.44  ? 500  ARG A N   1 
ATOM   1564 C  CA  . ARG A 1 237 ? -16.584 -36.359 -35.777 1.00 35.69  ? 500  ARG A CA  1 
ATOM   1565 C  C   . ARG A 1 237 ? -16.921 -35.736 -37.145 1.00 37.95  ? 500  ARG A C   1 
ATOM   1566 O  O   . ARG A 1 237 ? -16.049 -35.026 -37.720 1.00 35.58  ? 500  ARG A O   1 
ATOM   1567 C  CB  . ARG A 1 237 ? -16.135 -37.813 -35.884 1.00 38.71  ? 500  ARG A CB  1 
ATOM   1568 C  CG  . ARG A 1 237 ? -14.765 -37.911 -36.542 1.00 36.10  ? 500  ARG A CG  1 
ATOM   1569 C  CD  . ARG A 1 237 ? -14.001 -39.145 -36.141 1.00 35.55  ? 500  ARG A CD  1 
ATOM   1570 N  NE  . ARG A 1 237 ? -12.637 -39.073 -36.590 1.00 34.58  ? 500  ARG A NE  1 
ATOM   1571 C  CZ  . ARG A 1 237 ? -11.644 -38.460 -35.935 1.00 33.04  ? 500  ARG A CZ  1 
ATOM   1572 N  NH1 . ARG A 1 237 ? -11.851 -37.865 -34.775 1.00 28.97  ? 500  ARG A NH1 1 
ATOM   1573 N  NH2 . ARG A 1 237 ? -10.422 -38.510 -36.421 1.00 35.98  ? 500  ARG A NH2 1 
ATOM   1574 N  N   . GLU A 1 238 ? -18.115 -36.035 -37.672 0.50 39.56  ? 501  GLU A N   1 
ATOM   1575 C  CA  . GLU A 1 238 ? -18.594 -35.559 -39.002 0.50 41.54  ? 501  GLU A CA  1 
ATOM   1576 C  C   . GLU A 1 238 ? -18.425 -34.036 -39.067 0.50 36.83  ? 501  GLU A C   1 
ATOM   1577 O  O   . GLU A 1 238 ? -17.866 -33.536 -40.069 0.50 39.81  ? 501  GLU A O   1 
ATOM   1578 C  CB  . GLU A 1 238 ? -20.052 -35.971 -39.260 0.50 46.17  ? 501  GLU A CB  1 
ATOM   1579 C  CG  . GLU A 1 238 ? -20.684 -35.238 -40.438 0.50 51.55  ? 501  GLU A CG  1 
ATOM   1580 C  CD  . GLU A 1 238 ? -22.133 -35.584 -40.773 0.50 58.12  ? 501  GLU A CD  1 
ATOM   1581 O  OE1 . GLU A 1 238 ? -22.864 -34.676 -41.232 0.50 55.71  ? 501  GLU A OE1 1 
ATOM   1582 O  OE2 . GLU A 1 238 ? -22.528 -36.763 -40.602 0.50 62.73  ? 501  GLU A OE2 1 
ATOM   1583 N  N   . ASN A 1 239 ? -18.851 -33.330 -38.018 0.50 35.71  ? 502  ASN A N   1 
ATOM   1584 C  CA  . ASN A 1 239 ? -18.816 -31.848 -37.980 0.50 37.00  ? 502  ASN A CA  1 
ATOM   1585 C  C   . ASN A 1 239 ? -17.383 -31.317 -37.817 0.50 36.26  ? 502  ASN A C   1 
ATOM   1586 O  O   . ASN A 1 239 ? -16.986 -30.535 -38.686 0.50 36.17  ? 502  ASN A O   1 
ATOM   1587 C  CB  . ASN A 1 239 ? -19.676 -31.257 -36.865 0.50 37.75  ? 502  ASN A CB  1 
ATOM   1588 C  CG  . ASN A 1 239 ? -19.894 -29.778 -37.088 0.50 37.53  ? 502  ASN A CG  1 
ATOM   1589 O  OD1 . ASN A 1 239 ? -20.256 -29.370 -38.190 0.50 36.71  ? 502  ASN A OD1 1 
ATOM   1590 N  ND2 . ASN A 1 239 ? -19.626 -28.970 -36.074 0.50 39.80  ? 502  ASN A ND2 1 
ATOM   1591 N  N   . SER A 1 240 ? -16.678 -31.686 -36.730 0.50 35.47  ? 503  SER A N   1 
ATOM   1592 C  CA  . SER A 1 240 ? -15.439 -31.031 -36.209 0.50 34.45  ? 503  SER A CA  1 
ATOM   1593 C  C   . SER A 1 240 ? -14.152 -31.738 -36.662 0.50 33.61  ? 503  SER A C   1 
ATOM   1594 O  O   . SER A 1 240 ? -13.082 -31.122 -36.497 0.50 32.17  ? 503  SER A O   1 
ATOM   1595 C  CB  . SER A 1 240 ? -15.458 -30.936 -34.699 0.50 35.71  ? 503  SER A CB  1 
ATOM   1596 O  OG  . SER A 1 240 ? -15.211 -32.210 -34.095 0.50 36.86  ? 503  SER A OG  1 
ATOM   1597 N  N   . LEU A 1 241 ? -14.248 -32.976 -37.163 1.00 34.46  ? 504  LEU A N   1 
ATOM   1598 C  CA  . LEU A 1 241 ? -13.132 -33.753 -37.796 1.00 34.95  ? 504  LEU A CA  1 
ATOM   1599 C  C   . LEU A 1 241 ? -12.159 -34.405 -36.776 1.00 35.56  ? 504  LEU A C   1 
ATOM   1600 O  O   . LEU A 1 241 ? -11.753 -35.555 -37.002 1.00 33.99  ? 504  LEU A O   1 
ATOM   1601 C  CB  . LEU A 1 241 ? -12.398 -32.922 -38.855 1.00 41.21  ? 504  LEU A CB  1 
ATOM   1602 C  CG  . LEU A 1 241 ? -13.230 -32.299 -39.983 1.00 48.64  ? 504  LEU A CG  1 
ATOM   1603 C  CD1 . LEU A 1 241 ? -12.312 -31.668 -41.034 1.00 49.43  ? 504  LEU A CD1 1 
ATOM   1604 C  CD2 . LEU A 1 241 ? -14.101 -33.316 -40.666 1.00 54.61  ? 504  LEU A CD2 1 
ATOM   1605 N  N   . SER A 1 242 ? -11.804 -33.688 -35.702 0.50 32.45  ? 505  SER A N   1 
ATOM   1606 C  CA  . SER A 1 242 ? -10.971 -34.202 -34.582 0.50 33.13  ? 505  SER A CA  1 
ATOM   1607 C  C   . SER A 1 242 ? -11.857 -34.801 -33.485 0.50 30.03  ? 505  SER A C   1 
ATOM   1608 O  O   . SER A 1 242 ? -11.385 -35.702 -32.775 0.50 27.41  ? 505  SER A O   1 
ATOM   1609 C  CB  . SER A 1 242 ? -10.084 -33.117 -34.013 0.50 32.53  ? 505  SER A CB  1 
ATOM   1610 O  OG  . SER A 1 242 ? -9.477  -32.390 -35.057 0.50 34.97  ? 505  SER A OG  1 
ATOM   1611 N  N   . GLY A 1 243 ? -13.065 -34.270 -33.309 1.00 29.66  ? 506  GLY A N   1 
ATOM   1612 C  CA  . GLY A 1 243 ? -13.947 -34.661 -32.193 1.00 29.56  ? 506  GLY A CA  1 
ATOM   1613 C  C   . GLY A 1 243 ? -14.511 -36.049 -32.345 1.00 29.38  ? 506  GLY A C   1 
ATOM   1614 O  O   . GLY A 1 243 ? -14.389 -36.636 -33.414 1.00 29.67  ? 506  GLY A O   1 
ATOM   1615 N  N   . VAL A 1 244 ? -15.057 -36.546 -31.231 1.00 30.17  ? 507  VAL A N   1 
ATOM   1616 C  CA  . VAL A 1 244 ? -15.631 -37.915 -31.151 1.00 37.23  ? 507  VAL A CA  1 
ATOM   1617 C  C   . VAL A 1 244 ? -16.906 -37.881 -30.281 1.00 35.15  ? 507  VAL A C   1 
ATOM   1618 O  O   . VAL A 1 244 ? -17.282 -38.929 -29.757 1.00 36.20  ? 507  VAL A O   1 
ATOM   1619 C  CB  . VAL A 1 244 ? -14.589 -38.885 -30.557 1.00 32.79  ? 507  VAL A CB  1 
ATOM   1620 C  CG1 . VAL A 1 244 ? -13.405 -39.104 -31.482 1.00 34.40  ? 507  VAL A CG1 1 
ATOM   1621 C  CG2 . VAL A 1 244 ? -14.123 -38.444 -29.181 1.00 32.34  ? 507  VAL A CG2 1 
ATOM   1622 N  N   . GLU A 1 245 ? -17.535 -36.717 -30.117 1.00 36.19  ? 508  GLU A N   1 
ATOM   1623 C  CA  . GLU A 1 245 ? -18.733 -36.601 -29.235 1.00 38.26  ? 508  GLU A CA  1 
ATOM   1624 C  C   . GLU A 1 245 ? -19.886 -37.436 -29.800 1.00 33.17  ? 508  GLU A C   1 
ATOM   1625 O  O   . GLU A 1 245 ? -20.160 -37.311 -30.992 1.00 30.56  ? 508  GLU A O   1 
ATOM   1626 C  CB  . GLU A 1 245 ? -19.148 -35.143 -29.037 1.00 41.45  ? 508  GLU A CB  1 
ATOM   1627 C  CG  . GLU A 1 245 ? -20.255 -34.951 -28.016 1.00 49.91  ? 508  GLU A CG  1 
ATOM   1628 C  CD  . GLU A 1 245 ? -21.662 -35.206 -28.530 1.00 56.78  ? 508  GLU A CD  1 
ATOM   1629 O  OE1 . GLU A 1 245 ? -21.898 -34.987 -29.729 1.00 63.17  ? 508  GLU A OE1 1 
ATOM   1630 O  OE2 . GLU A 1 245 ? -22.514 -35.630 -27.729 1.00 67.48  ? 508  GLU A OE2 1 
ATOM   1631 N  N   . GLY A 1 246 ? -20.497 -38.272 -28.958 0.50 35.37  ? 509  GLY A N   1 
ATOM   1632 C  CA  . GLY A 1 246 ? -21.623 -39.124 -29.387 0.50 37.73  ? 509  GLY A CA  1 
ATOM   1633 C  C   . GLY A 1 246 ? -21.169 -40.345 -30.163 0.50 39.48  ? 509  GLY A C   1 
ATOM   1634 O  O   . GLY A 1 246 ? -22.038 -41.047 -30.697 0.50 40.19  ? 509  GLY A O   1 
ATOM   1635 N  N   . GLU A 1 247 ? -19.862 -40.600 -30.219 1.00 39.33  ? 510  GLU A N   1 
ATOM   1636 C  CA  . GLU A 1 247 ? -19.357 -41.718 -31.057 1.00 40.98  ? 510  GLU A CA  1 
ATOM   1637 C  C   . GLU A 1 247 ? -19.626 -43.058 -30.365 1.00 39.92  ? 510  GLU A C   1 
ATOM   1638 O  O   . GLU A 1 247 ? -20.227 -43.920 -31.012 1.00 53.74  ? 510  GLU A O   1 
ATOM   1639 C  CB  . GLU A 1 247 ? -17.886 -41.517 -31.429 1.00 41.53  ? 510  GLU A CB  1 
ATOM   1640 C  CG  . GLU A 1 247 ? -17.664 -40.371 -32.393 1.00 48.60  ? 510  GLU A CG  1 
ATOM   1641 C  CD  . GLU A 1 247 ? -18.446 -40.476 -33.688 1.00 57.29  ? 510  GLU A CD  1 
ATOM   1642 O  OE1 . GLU A 1 247 ? -18.579 -41.598 -34.200 1.00 57.96  ? 510  GLU A OE1 1 
ATOM   1643 O  OE2 . GLU A 1 247 ? -18.928 -39.435 -34.171 1.00 63.19  ? 510  GLU A OE2 1 
ATOM   1644 N  N   . GLY A 1 248 ? -19.205 -43.224 -29.116 0.50 37.83  ? 511  GLY A N   1 
ATOM   1645 C  CA  . GLY A 1 248 ? -19.367 -44.538 -28.471 0.50 38.67  ? 511  GLY A CA  1 
ATOM   1646 C  C   . GLY A 1 248 ? -18.044 -45.266 -28.352 0.50 39.30  ? 511  GLY A C   1 
ATOM   1647 O  O   . GLY A 1 248 ? -17.329 -45.303 -29.364 0.50 38.01  ? 511  GLY A O   1 
ATOM   1648 N  N   A LEU A 1 249 ? -17.920 -46.120 -27.333 0.25 37.96  ? 512  LEU A N   1 
ATOM   1649 N  N   B LEU A 1 249 ? -17.915 -46.113 -27.327 0.25 39.01  ? 512  LEU A N   1 
ATOM   1650 C  CA  A LEU A 1 249 ? -16.649 -46.856 -27.104 0.25 37.75  ? 512  LEU A CA  1 
ATOM   1651 C  CA  B LEU A 1 249 ? -16.649 -46.861 -27.105 0.25 39.27  ? 512  LEU A CA  1 
ATOM   1652 C  C   A LEU A 1 249 ? -16.465 -47.914 -28.195 0.25 38.54  ? 512  LEU A C   1 
ATOM   1653 C  C   B LEU A 1 249 ? -16.460 -47.895 -28.215 0.25 39.40  ? 512  LEU A C   1 
ATOM   1654 O  O   A LEU A 1 249 ? -15.425 -48.583 -28.157 0.25 38.30  ? 512  LEU A O   1 
ATOM   1655 O  O   B LEU A 1 249 ? -15.420 -48.564 -28.173 0.25 38.29  ? 512  LEU A O   1 
ATOM   1656 C  CB  A LEU A 1 249 ? -16.713 -47.490 -25.711 0.25 36.48  ? 512  LEU A CB  1 
ATOM   1657 C  CB  B LEU A 1 249 ? -16.709 -47.542 -25.735 0.25 39.29  ? 512  LEU A CB  1 
ATOM   1658 C  CG  A LEU A 1 249 ? -15.381 -47.948 -25.123 0.25 35.29  ? 512  LEU A CG  1 
ATOM   1659 C  CG  B LEU A 1 249 ? -15.688 -47.061 -24.707 0.25 38.92  ? 512  LEU A CG  1 
ATOM   1660 C  CD1 A LEU A 1 249 ? -14.390 -46.797 -25.066 0.25 35.63  ? 512  LEU A CD1 1 
ATOM   1661 C  CD1 B LEU A 1 249 ? -15.781 -47.891 -23.436 0.25 38.50  ? 512  LEU A CD1 1 
ATOM   1662 C  CD2 A LEU A 1 249 ? -15.586 -48.545 -23.740 0.25 35.18  ? 512  LEU A CD2 1 
ATOM   1663 C  CD2 B LEU A 1 249 ? -14.279 -47.117 -25.275 0.25 38.73  ? 512  LEU A CD2 1 
ATOM   1664 N  N   . HIS A 1 250 ? -17.557 -48.283 -28.871 0.50 37.33  ? 513  HIS A N   1 
ATOM   1665 C  CA  . HIS A 1 250 ? -17.486 -49.304 -29.953 0.50 37.53  ? 513  HIS A CA  1 
ATOM   1666 C  C   . HIS A 1 250 ? -17.012 -48.686 -31.271 0.50 36.31  ? 513  HIS A C   1 
ATOM   1667 O  O   . HIS A 1 250 ? -16.864 -49.437 -32.246 0.50 38.03  ? 513  HIS A O   1 
ATOM   1668 C  CB  . HIS A 1 250 ? -18.862 -49.952 -30.128 0.50 39.80  ? 513  HIS A CB  1 
ATOM   1669 C  CG  . HIS A 1 250 ? -19.968 -48.961 -30.259 0.50 39.41  ? 513  HIS A CG  1 
ATOM   1670 N  ND1 . HIS A 1 250 ? -20.588 -48.703 -31.462 0.50 40.58  ? 513  HIS A ND1 1 
ATOM   1671 C  CD2 . HIS A 1 250 ? -20.556 -48.157 -29.349 0.50 40.05  ? 513  HIS A CD2 1 
ATOM   1672 C  CE1 . HIS A 1 250 ? -21.518 -47.788 -31.287 0.50 41.02  ? 513  HIS A CE1 1 
ATOM   1673 N  NE2 . HIS A 1 250 ? -21.517 -47.436 -30.000 0.50 41.28  ? 513  HIS A NE2 1 
ATOM   1674 N  N   . LYS A 1 251 ? -16.806 -47.370 -31.300 1.00 37.26  ? 514  LYS A N   1 
ATOM   1675 C  CA  . LYS A 1 251 ? -16.369 -46.672 -32.536 1.00 38.75  ? 514  LYS A CA  1 
ATOM   1676 C  C   . LYS A 1 251 ? -14.974 -46.058 -32.358 1.00 35.48  ? 514  LYS A C   1 
ATOM   1677 O  O   . LYS A 1 251 ? -14.307 -45.874 -33.370 1.00 35.75  ? 514  LYS A O   1 
ATOM   1678 C  CB  . LYS A 1 251 ? -17.405 -45.608 -32.897 1.00 44.50  ? 514  LYS A CB  1 
ATOM   1679 C  CG  . LYS A 1 251 ? -18.855 -46.047 -32.753 1.00 50.56  ? 514  LYS A CG  1 
ATOM   1680 C  CD  . LYS A 1 251 ? -19.622 -46.031 -34.049 1.00 51.71  ? 514  LYS A CD  1 
ATOM   1681 C  CE  . LYS A 1 251 ? -19.777 -44.640 -34.622 1.00 61.70  ? 514  LYS A CE  1 
ATOM   1682 N  NZ  . LYS A 1 251 ? -20.677 -44.633 -35.797 1.00 67.04  ? 514  LYS A NZ  1 
ATOM   1683 N  N   . LEU A 1 252 ? -14.545 -45.795 -31.124 1.00 32.79  ? 515  LEU A N   1 
ATOM   1684 C  CA  . LEU A 1 252 ? -13.254 -45.086 -30.854 1.00 36.09  ? 515  LEU A CA  1 
ATOM   1685 C  C   . LEU A 1 252 ? -12.084 -45.876 -31.460 1.00 31.73  ? 515  LEU A C   1 
ATOM   1686 O  O   . LEU A 1 252 ? -11.184 -45.268 -32.082 1.00 35.79  ? 515  LEU A O   1 
ATOM   1687 C  CB  . LEU A 1 252 ? -13.083 -44.901 -29.343 1.00 31.42  ? 515  LEU A CB  1 
ATOM   1688 C  CG  . LEU A 1 252 ? -14.109 -43.984 -28.693 1.00 32.98  ? 515  LEU A CG  1 
ATOM   1689 C  CD1 . LEU A 1 252 ? -13.720 -43.624 -27.280 1.00 35.80  ? 515  LEU A CD1 1 
ATOM   1690 C  CD2 . LEU A 1 252 ? -14.321 -42.737 -29.498 1.00 33.37  ? 515  LEU A CD2 1 
ATOM   1691 N  N   . GLY A 1 253 ? -12.096 -47.200 -31.276 1.00 29.37  ? 516  GLY A N   1 
ATOM   1692 C  CA  . GLY A 1 253 ? -11.097 -48.107 -31.853 1.00 31.81  ? 516  GLY A CA  1 
ATOM   1693 C  C   . GLY A 1 253 ? -10.976 -47.951 -33.352 1.00 32.63  ? 516  GLY A C   1 
ATOM   1694 O  O   . GLY A 1 253 ? -9.826  -47.806 -33.871 1.00 32.74  ? 516  GLY A O   1 
ATOM   1695 N  N   . TYR A 1 254 ? -12.108 -47.986 -34.034 1.00 29.69  ? 517  TYR A N   1 
ATOM   1696 C  CA  . TYR A 1 254 ? -12.165 -47.852 -35.507 1.00 31.88  ? 517  TYR A CA  1 
ATOM   1697 C  C   . TYR A 1 254 ? -11.662 -46.466 -35.924 1.00 29.95  ? 517  TYR A C   1 
ATOM   1698 O  O   . TYR A 1 254 ? -10.975 -46.343 -36.971 1.00 31.00  ? 517  TYR A O   1 
ATOM   1699 C  CB  . TYR A 1 254 ? -13.578 -48.065 -36.044 1.00 31.67  ? 517  TYR A CB  1 
ATOM   1700 C  CG  . TYR A 1 254 ? -14.028 -49.503 -36.086 1.00 31.14  ? 517  TYR A CG  1 
ATOM   1701 C  CD1 . TYR A 1 254 ? -13.461 -50.409 -36.984 1.00 30.69  ? 517  TYR A CD1 1 
ATOM   1702 C  CD2 . TYR A 1 254 ? -15.017 -49.963 -35.225 1.00 31.73  ? 517  TYR A CD2 1 
ATOM   1703 C  CE1 . TYR A 1 254 ? -13.858 -51.739 -37.031 1.00 29.90  ? 517  TYR A CE1 1 
ATOM   1704 C  CE2 . TYR A 1 254 ? -15.455 -51.280 -35.287 1.00 34.33  ? 517  TYR A CE2 1 
ATOM   1705 C  CZ  . TYR A 1 254 ? -14.877 -52.170 -36.194 1.00 34.45  ? 517  TYR A CZ  1 
ATOM   1706 O  OH  . TYR A 1 254 ? -15.321 -53.472 -36.255 1.00 35.61  ? 517  TYR A OH  1 
ATOM   1707 N  N   . ILE A 1 255 ? -11.988 -45.457 -35.151 1.00 28.49  ? 518  ILE A N   1 
ATOM   1708 C  CA  . ILE A 1 255 ? -11.541 -44.078 -35.432 1.00 33.86  ? 518  ILE A CA  1 
ATOM   1709 C  C   . ILE A 1 255 ? -10.002 -43.994 -35.300 1.00 33.88  ? 518  ILE A C   1 
ATOM   1710 O  O   . ILE A 1 255 ? -9.400  -43.437 -36.238 1.00 36.29  ? 518  ILE A O   1 
ATOM   1711 C  CB  . ILE A 1 255 ? -12.309 -43.070 -34.555 1.00 34.05  ? 518  ILE A CB  1 
ATOM   1712 C  CG1 . ILE A 1 255 ? -13.773 -42.954 -35.014 1.00 36.09  ? 518  ILE A CG1 1 
ATOM   1713 C  CG2 . ILE A 1 255 ? -11.592 -41.714 -34.534 1.00 31.57  ? 518  ILE A CG2 1 
ATOM   1714 C  CD1 . ILE A 1 255 ? -14.688 -42.174 -34.032 1.00 35.58  ? 518  ILE A CD1 1 
ATOM   1715 N  N   . LEU A 1 256 ? -9.394  -44.517 -34.220 1.00 32.82  ? 519  LEU A N   1 
ATOM   1716 C  CA  . LEU A 1 256 ? -7.924  -44.545 -34.051 1.00 38.06  ? 519  LEU A CA  1 
ATOM   1717 C  C   . LEU A 1 256 ? -7.280  -45.320 -35.191 1.00 37.22  ? 519  LEU A C   1 
ATOM   1718 O  O   . LEU A 1 256 ? -6.215  -44.869 -35.662 1.00 38.48  ? 519  LEU A O   1 
ATOM   1719 C  CB  . LEU A 1 256 ? -7.509  -45.184 -32.735 1.00 38.82  ? 519  LEU A CB  1 
ATOM   1720 C  CG  . LEU A 1 256 ? -7.792  -44.362 -31.492 1.00 37.84  ? 519  LEU A CG  1 
ATOM   1721 C  CD1 . LEU A 1 256 ? -7.129  -45.041 -30.311 1.00 39.22  ? 519  LEU A CD1 1 
ATOM   1722 C  CD2 . LEU A 1 256 ? -7.319  -42.919 -31.645 1.00 40.71  ? 519  LEU A CD2 1 
ATOM   1723 N  N   . ARG A 1 257 ? -7.872  -46.449 -35.594 1.00 35.77  ? 520  ARG A N   1 
ATOM   1724 C  CA  . ARG A 1 257 ? -7.356  -47.225 -36.761 1.00 38.34  ? 520  ARG A CA  1 
ATOM   1725 C  C   . ARG A 1 257 ? -7.408  -46.373 -38.033 1.00 37.63  ? 520  ARG A C   1 
ATOM   1726 O  O   . ARG A 1 257 ? -6.441  -46.481 -38.805 1.00 35.50  ? 520  ARG A O   1 
ATOM   1727 C  CB  . ARG A 1 257 ? -8.070  -48.551 -36.973 1.00 37.15  ? 520  ARG A CB  1 
ATOM   1728 C  CG  . ARG A 1 257 ? -7.425  -49.446 -38.028 1.00 39.95  ? 520  ARG A CG  1 
ATOM   1729 C  CD  . ARG A 1 257 ? -8.160  -50.761 -38.274 1.00 37.50  ? 520  ARG A CD  1 
ATOM   1730 N  NE  . ARG A 1 257 ? -9.484  -50.563 -38.899 1.00 40.60  ? 520  ARG A NE  1 
ATOM   1731 C  CZ  . ARG A 1 257 ? -10.306 -51.541 -39.256 1.00 35.15  ? 520  ARG A CZ  1 
ATOM   1732 N  NH1 . ARG A 1 257 ? -10.014 -52.801 -38.999 1.00 38.97  ? 520  ARG A NH1 1 
ATOM   1733 N  NH2 . ARG A 1 257 ? -11.452 -51.251 -39.829 1.00 45.39  ? 520  ARG A NH2 1 
ATOM   1734 N  N   . ASP A 1 258 ? -8.436  -45.538 -38.229 1.00 35.86  ? 521  ASP A N   1 
ATOM   1735 C  CA  . ASP A 1 258 ? -8.510  -44.702 -39.473 1.00 40.32  ? 521  ASP A CA  1 
ATOM   1736 C  C   . ASP A 1 258 ? -7.382  -43.647 -39.466 1.00 34.14  ? 521  ASP A C   1 
ATOM   1737 O  O   . ASP A 1 258 ? -6.765  -43.435 -40.492 1.00 42.12  ? 521  ASP A O   1 
ATOM   1738 C  CB  . ASP A 1 258 ? -9.887  -44.070 -39.720 1.00 39.17  ? 521  ASP A CB  1 
ATOM   1739 C  CG  . ASP A 1 258 ? -10.924 -44.992 -40.391 1.00 44.24  ? 521  ASP A CG  1 
ATOM   1740 O  OD1 . ASP A 1 258 ? -10.558 -46.072 -40.872 1.00 40.44  ? 521  ASP A OD1 1 
ATOM   1741 O  OD2 . ASP A 1 258 ? -12.115 -44.637 -40.385 1.00 40.98  ? 521  ASP A OD2 1 
ATOM   1742 N  N   . VAL A 1 259 ? -7.168  -42.961 -38.360 1.00 31.86  ? 522  VAL A N   1 
ATOM   1743 C  CA  . VAL A 1 259 ? -6.046  -42.004 -38.183 1.00 38.86  ? 522  VAL A CA  1 
ATOM   1744 C  C   . VAL A 1 259 ? -4.729  -42.731 -38.499 1.00 37.76  ? 522  VAL A C   1 
ATOM   1745 O  O   . VAL A 1 259 ? -3.958  -42.174 -39.212 1.00 41.23  ? 522  VAL A O   1 
ATOM   1746 C  CB  . VAL A 1 259 ? -6.042  -41.455 -36.753 1.00 40.66  ? 522  VAL A CB  1 
ATOM   1747 C  CG1 . VAL A 1 259 ? -4.805  -40.605 -36.514 1.00 39.38  ? 522  VAL A CG1 1 
ATOM   1748 C  CG2 . VAL A 1 259 ? -7.339  -40.684 -36.471 1.00 40.07  ? 522  VAL A CG2 1 
ATOM   1749 N  N   . SER A 1 260 ? -4.529  -43.966 -38.035 1.00 38.76  ? 523  SER A N   1 
ATOM   1750 C  CA  . SER A 1 260 ? -3.292  -44.762 -38.287 1.00 41.26  ? 523  SER A CA  1 
ATOM   1751 C  C   . SER A 1 260 ? -3.066  -44.938 -39.794 1.00 40.07  ? 523  SER A C   1 
ATOM   1752 O  O   . SER A 1 260 ? -1.960  -45.034 -40.173 1.00 39.95  ? 523  SER A O   1 
ATOM   1753 C  CB  . SER A 1 260 ? -3.311  -46.088 -37.588 1.00 40.46  ? 523  SER A CB  1 
ATOM   1754 O  OG  . SER A 1 260 ? -3.959  -47.072 -38.384 1.00 45.87  ? 523  SER A OG  1 
ATOM   1755 N  N   . LYS A 1 261 ? -4.108  -44.931 -40.610 1.00 41.44  ? 524  LYS A N   1 
ATOM   1756 C  CA  . LYS A 1 261 ? -4.047  -45.221 -42.064 1.00 43.31  ? 524  LYS A CA  1 
ATOM   1757 C  C   . LYS A 1 261 ? -3.394  -44.060 -42.817 1.00 42.69  ? 524  LYS A C   1 
ATOM   1758 O  O   . LYS A 1 261 ? -2.938  -44.306 -43.949 1.00 43.17  ? 524  LYS A O   1 
ATOM   1759 C  CB  . LYS A 1 261 ? -5.456  -45.466 -42.612 1.00 44.47  ? 524  LYS A CB  1 
ATOM   1760 C  CG  . LYS A 1 261 ? -5.882  -46.913 -42.501 1.00 59.23  ? 524  LYS A CG  1 
ATOM   1761 C  CD  . LYS A 1 261 ? -7.341  -47.176 -42.810 1.00 65.36  ? 524  LYS A CD  1 
ATOM   1762 C  CE  . LYS A 1 261 ? -7.676  -48.636 -42.617 1.00 77.10  ? 524  LYS A CE  1 
ATOM   1763 N  NZ  . LYS A 1 261 ? -9.074  -48.907 -43.022 1.00 97.85  ? 524  LYS A NZ  1 
ATOM   1764 N  N   . LYS A 1 262 ? -3.421  -42.856 -42.240 1.00 43.81  ? 525  LYS A N   1 
ATOM   1765 C  CA  . LYS A 1 262 ? -2.793  -41.623 -42.789 1.00 48.05  ? 525  LYS A CA  1 
ATOM   1766 C  C   . LYS A 1 262 ? -1.269  -41.772 -42.810 1.00 44.45  ? 525  LYS A C   1 
ATOM   1767 O  O   . LYS A 1 262 ? -0.716  -42.338 -41.876 1.00 50.69  ? 525  LYS A O   1 
ATOM   1768 C  CB  . LYS A 1 262 ? -3.158  -40.393 -41.951 1.00 48.95  ? 525  LYS A CB  1 
ATOM   1769 C  CG  . LYS A 1 262 ? -4.661  -40.147 -41.869 1.00 51.69  ? 525  LYS A CG  1 
ATOM   1770 C  CD  . LYS A 1 262 ? -5.051  -38.716 -41.866 1.00 52.79  ? 525  LYS A CD  1 
ATOM   1771 C  CE  . LYS A 1 262 ? -6.496  -38.469 -42.234 1.00 61.65  ? 525  LYS A CE  1 
ATOM   1772 N  NZ  . LYS A 1 262 ? -6.602  -37.301 -43.150 1.00 66.89  ? 525  LYS A NZ  1 
ATOM   1773 N  N   . GLU A 1 263 ? -0.629  -41.219 -43.827 1.00 46.30  ? 526  GLU A N   1 
ATOM   1774 C  CA  . GLU A 1 263 ? 0.845   -41.076 -43.899 1.00 47.07  ? 526  GLU A CA  1 
ATOM   1775 C  C   . GLU A 1 263 ? 1.251   -40.117 -42.786 1.00 44.23  ? 526  GLU A C   1 
ATOM   1776 O  O   . GLU A 1 263 ? 0.567   -39.087 -42.656 1.00 44.37  ? 526  GLU A O   1 
ATOM   1777 C  CB  . GLU A 1 263 ? 1.237   -40.514 -45.264 1.00 59.09  ? 526  GLU A CB  1 
ATOM   1778 C  CG  . GLU A 1 263 ? 0.927   -41.451 -46.433 1.00 71.93  ? 526  GLU A CG  1 
ATOM   1779 C  CD  . GLU A 1 263 ? 1.966   -42.541 -46.656 1.00 85.61  ? 526  GLU A CD  1 
ATOM   1780 O  OE1 . GLU A 1 263 ? 3.141   -42.193 -46.970 1.00 98.92  ? 526  GLU A OE1 1 
ATOM   1781 O  OE2 . GLU A 1 263 ? 1.607   -43.732 -46.510 1.00 83.56  ? 526  GLU A OE2 1 
ATOM   1782 N  N   . GLY A 1 264 ? 2.249   -40.473 -41.977 1.00 39.43  ? 527  GLY A N   1 
ATOM   1783 C  CA  . GLY A 1 264 ? 2.855   -39.546 -40.999 1.00 41.53  ? 527  GLY A CA  1 
ATOM   1784 C  C   . GLY A 1 264 ? 3.835   -40.231 -40.054 1.00 41.54  ? 527  GLY A C   1 
ATOM   1785 O  O   . GLY A 1 264 ? 4.318   -41.334 -40.341 1.00 44.55  ? 527  GLY A O   1 
ATOM   1786 N  N   . GLY A 1 265 ? 4.104   -39.631 -38.904 1.00 44.94  ? 528  GLY A N   1 
ATOM   1787 C  CA  . GLY A 1 265 ? 4.987   -40.278 -37.916 1.00 46.89  ? 528  GLY A CA  1 
ATOM   1788 C  C   . GLY A 1 265 ? 4.233   -41.131 -36.902 1.00 46.82  ? 528  GLY A C   1 
ATOM   1789 O  O   . GLY A 1 265 ? 3.217   -41.752 -37.241 1.00 48.04  ? 528  GLY A O   1 
ATOM   1790 N  N   . ALA A 1 266 ? 4.750   -41.163 -35.687 1.00 39.63  ? 529  ALA A N   1 
ATOM   1791 C  CA  . ALA A 1 266 ? 4.205   -41.916 -34.551 1.00 37.85  ? 529  ALA A CA  1 
ATOM   1792 C  C   . ALA A 1 266 ? 2.853   -41.297 -34.201 1.00 35.70  ? 529  ALA A C   1 
ATOM   1793 O  O   . ALA A 1 266 ? 2.569   -40.175 -34.658 1.00 38.24  ? 529  ALA A O   1 
ATOM   1794 C  CB  . ALA A 1 266 ? 5.197   -41.842 -33.396 1.00 34.69  ? 529  ALA A CB  1 
ATOM   1795 N  N   . MET A 1 267 ? 2.075   -41.983 -33.381 1.00 35.11  ? 530  MET A N   1 
ATOM   1796 C  CA  . MET A 1 267 ? 0.858   -41.424 -32.749 1.00 36.37  ? 530  MET A CA  1 
ATOM   1797 C  C   . MET A 1 267 ? 1.297   -40.881 -31.378 1.00 32.90  ? 530  MET A C   1 
ATOM   1798 O  O   . MET A 1 267 ? 2.044   -41.562 -30.647 1.00 40.85  ? 530  MET A O   1 
ATOM   1799 C  CB  . MET A 1 267 ? -0.241  -42.494 -32.658 1.00 38.29  ? 530  MET A CB  1 
ATOM   1800 C  CG  . MET A 1 267 ? -0.765  -42.934 -34.044 1.00 42.89  ? 530  MET A CG  1 
ATOM   1801 S  SD  . MET A 1 267 ? -2.214  -44.056 -34.043 1.00 46.07  ? 530  MET A SD  1 
ATOM   1802 C  CE  . MET A 1 267 ? -3.605  -42.941 -33.995 1.00 53.78  ? 530  MET A CE  1 
ATOM   1803 N  N   . TYR A 1 268 ? 0.927   -39.658 -31.055 1.00 31.21  ? 531  TYR A N   1 
ATOM   1804 C  CA  . TYR A 1 268 ? 1.287   -39.010 -29.785 1.00 30.11  ? 531  TYR A CA  1 
ATOM   1805 C  C   . TYR A 1 268 ? 0.003   -38.904 -28.984 1.00 33.91  ? 531  TYR A C   1 
ATOM   1806 O  O   . TYR A 1 268 ? -1.031  -38.553 -29.562 1.00 37.25  ? 531  TYR A O   1 
ATOM   1807 C  CB  . TYR A 1 268 ? 1.966   -37.670 -30.040 1.00 30.70  ? 531  TYR A CB  1 
ATOM   1808 C  CG  . TYR A 1 268 ? 3.275   -37.817 -30.756 1.00 33.17  ? 531  TYR A CG  1 
ATOM   1809 C  CD1 . TYR A 1 268 ? 3.313   -38.009 -32.118 1.00 30.74  ? 531  TYR A CD1 1 
ATOM   1810 C  CD2 . TYR A 1 268 ? 4.457   -37.931 -30.036 1.00 33.50  ? 531  TYR A CD2 1 
ATOM   1811 C  CE1 . TYR A 1 268 ? 4.525   -38.206 -32.757 1.00 35.12  ? 531  TYR A CE1 1 
ATOM   1812 C  CE2 . TYR A 1 268 ? 5.664   -38.161 -30.660 1.00 33.29  ? 531  TYR A CE2 1 
ATOM   1813 C  CZ  . TYR A 1 268 ? 5.697   -38.299 -32.028 1.00 35.87  ? 531  TYR A CZ  1 
ATOM   1814 O  OH  . TYR A 1 268 ? 6.891   -38.516 -32.656 1.00 34.25  ? 531  TYR A OH  1 
ATOM   1815 N  N   . ALA A 1 269 ? 0.108   -39.172 -27.689 1.00 35.16  ? 532  ALA A N   1 
ATOM   1816 C  CA  . ALA A 1 269 ? -1.006  -39.125 -26.740 1.00 36.58  ? 532  ALA A CA  1 
ATOM   1817 C  C   . ALA A 1 269 ? -0.474  -38.567 -25.436 1.00 33.71  ? 532  ALA A C   1 
ATOM   1818 O  O   . ALA A 1 269 ? -0.532  -39.269 -24.439 1.00 40.48  ? 532  ALA A O   1 
ATOM   1819 C  CB  . ALA A 1 269 ? -1.643  -40.486 -26.585 1.00 35.35  ? 532  ALA A CB  1 
ATOM   1820 N  N   . ASP A 1 270 ? -0.071  -37.304 -25.437 1.00 32.50  ? 533  ASP A N   1 
ATOM   1821 C  CA  . ASP A 1 270 ? 0.393   -36.614 -24.210 1.00 33.94  ? 533  ASP A CA  1 
ATOM   1822 C  C   . ASP A 1 270 ? -0.812  -36.122 -23.430 1.00 38.93  ? 533  ASP A C   1 
ATOM   1823 O  O   . ASP A 1 270 ? -1.606  -35.388 -23.978 1.00 38.40  ? 533  ASP A O   1 
ATOM   1824 C  CB  . ASP A 1 270 ? 1.352   -35.465 -24.538 1.00 39.54  ? 533  ASP A CB  1 
ATOM   1825 C  CG  . ASP A 1 270 ? 2.581   -35.951 -25.291 1.00 40.97  ? 533  ASP A CG  1 
ATOM   1826 O  OD1 . ASP A 1 270 ? 2.895   -37.182 -25.172 1.00 41.44  ? 533  ASP A OD1 1 
ATOM   1827 O  OD2 . ASP A 1 270 ? 3.169   -35.149 -26.057 1.00 39.21  ? 533  ASP A OD2 1 
ATOM   1828 N  N   . ASP A 1 271 ? -0.937  -36.583 -22.183 0.50 40.39  ? 534  ASP A N   1 
ATOM   1829 C  CA  . ASP A 1 271 ? -1.838  -36.019 -21.147 0.50 42.63  ? 534  ASP A CA  1 
ATOM   1830 C  C   . ASP A 1 271 ? -1.326  -34.630 -20.762 0.50 41.35  ? 534  ASP A C   1 
ATOM   1831 O  O   . ASP A 1 271 ? -0.107  -34.405 -20.870 0.50 42.23  ? 534  ASP A O   1 
ATOM   1832 C  CB  . ASP A 1 271 ? -1.868  -36.876 -19.879 0.50 46.35  ? 534  ASP A CB  1 
ATOM   1833 C  CG  . ASP A 1 271 ? -2.336  -38.304 -20.092 0.50 49.37  ? 534  ASP A CG  1 
ATOM   1834 O  OD1 . ASP A 1 271 ? -2.679  -38.634 -21.237 0.50 51.97  ? 534  ASP A OD1 1 
ATOM   1835 O  OD2 . ASP A 1 271 ? -2.355  -39.073 -19.106 0.50 54.54  ? 534  ASP A OD2 1 
ATOM   1836 N  N   . THR A 1 272 ? -2.224  -33.751 -20.314 1.00 38.69  ? 535  THR A N   1 
ATOM   1837 C  CA  . THR A 1 272 ? -1.873  -32.459 -19.696 1.00 35.98  ? 535  THR A CA  1 
ATOM   1838 C  C   . THR A 1 272 ? -1.968  -32.672 -18.210 1.00 37.32  ? 535  THR A C   1 
ATOM   1839 O  O   . THR A 1 272 ? -2.909  -33.365 -17.790 1.00 43.62  ? 535  THR A O   1 
ATOM   1840 C  CB  . THR A 1 272 ? -2.793  -31.337 -20.179 1.00 38.78  ? 535  THR A CB  1 
ATOM   1841 O  OG1 . THR A 1 272 ? -2.459  -31.186 -21.554 1.00 44.00  ? 535  THR A OG1 1 
ATOM   1842 C  CG2 . THR A 1 272 ? -2.591  -30.015 -19.475 1.00 41.87  ? 535  THR A CG2 1 
ATOM   1843 N  N   . ALA A 1 273 ? -1.054  -32.068 -17.455 1.00 44.68  ? 536  ALA A N   1 
ATOM   1844 C  CA  . ALA A 1 273 ? -1.088  -32.042 -15.972 1.00 48.58  ? 536  ALA A CA  1 
ATOM   1845 C  C   . ALA A 1 273 ? -2.139  -31.014 -15.492 1.00 49.59  ? 536  ALA A C   1 
ATOM   1846 O  O   . ALA A 1 273 ? -1.878  -29.791 -15.584 1.00 56.17  ? 536  ALA A O   1 
ATOM   1847 C  CB  . ALA A 1 273 ? 0.300   -31.733 -15.455 1.00 49.74  ? 536  ALA A CB  1 
ATOM   1848 N  N   . GLY A 1 274 ? -3.289  -31.506 -15.016 0.50 48.76  ? 537  GLY A N   1 
ATOM   1849 C  CA  . GLY A 1 274 ? -4.394  -30.700 -14.452 0.50 49.39  ? 537  GLY A CA  1 
ATOM   1850 C  C   . GLY A 1 274 ? -4.930  -29.678 -15.442 0.50 47.05  ? 537  GLY A C   1 
ATOM   1851 O  O   . GLY A 1 274 ? -4.864  -28.469 -15.135 0.50 46.10  ? 537  GLY A O   1 
ATOM   1852 N  N   . TRP A 1 275 ? -5.451  -30.153 -16.578 1.00 43.89  ? 538  TRP A N   1 
ATOM   1853 C  CA  . TRP A 1 275 ? -5.930  -29.310 -17.712 1.00 43.20  ? 538  TRP A CA  1 
ATOM   1854 C  C   . TRP A 1 275 ? -6.816  -28.126 -17.290 1.00 40.79  ? 538  TRP A C   1 
ATOM   1855 O  O   . TRP A 1 275 ? -6.542  -27.018 -17.733 1.00 39.35  ? 538  TRP A O   1 
ATOM   1856 C  CB  . TRP A 1 275 ? -6.654  -30.169 -18.752 1.00 38.23  ? 538  TRP A CB  1 
ATOM   1857 C  CG  . TRP A 1 275 ? -7.280  -29.341 -19.824 1.00 36.15  ? 538  TRP A CG  1 
ATOM   1858 C  CD1 . TRP A 1 275 ? -8.505  -28.751 -19.764 1.00 36.04  ? 538  TRP A CD1 1 
ATOM   1859 C  CD2 . TRP A 1 275 ? -6.743  -29.027 -21.119 1.00 32.88  ? 538  TRP A CD2 1 
ATOM   1860 N  NE1 . TRP A 1 275 ? -8.759  -28.082 -20.929 1.00 38.58  ? 538  TRP A NE1 1 
ATOM   1861 C  CE2 . TRP A 1 275 ? -7.698  -28.219 -21.775 1.00 36.10  ? 538  TRP A CE2 1 
ATOM   1862 C  CE3 . TRP A 1 275 ? -5.577  -29.360 -21.806 1.00 32.97  ? 538  TRP A CE3 1 
ATOM   1863 C  CZ2 . TRP A 1 275 ? -7.512  -27.728 -23.065 1.00 36.69  ? 538  TRP A CZ2 1 
ATOM   1864 C  CZ3 . TRP A 1 275 ? -5.376  -28.848 -23.069 1.00 35.33  ? 538  TRP A CZ3 1 
ATOM   1865 C  CH2 . TRP A 1 275 ? -6.345  -28.078 -23.707 1.00 38.03  ? 538  TRP A CH2 1 
ATOM   1866 N  N   . ASP A 1 276 ? -7.837  -28.382 -16.467 0.50 42.48  ? 539  ASP A N   1 
ATOM   1867 C  CA  . ASP A 1 276 ? -8.825  -27.366 -15.999 0.50 46.34  ? 539  ASP A CA  1 
ATOM   1868 C  C   . ASP A 1 276 ? -8.078  -26.206 -15.330 0.50 47.99  ? 539  ASP A C   1 
ATOM   1869 O  O   . ASP A 1 276 ? -8.417  -25.036 -15.622 0.50 46.88  ? 539  ASP A O   1 
ATOM   1870 C  CB  . ASP A 1 276 ? -9.842  -27.957 -15.023 0.50 45.78  ? 539  ASP A CB  1 
ATOM   1871 C  CG  . ASP A 1 276 ? -10.715 -29.060 -15.601 0.50 49.15  ? 539  ASP A CG  1 
ATOM   1872 O  OD1 . ASP A 1 276 ? -11.134 -28.933 -16.770 0.50 49.06  ? 539  ASP A OD1 1 
ATOM   1873 O  OD2 . ASP A 1 276 ? -10.985 -30.031 -14.862 0.50 51.11  ? 539  ASP A OD2 1 
ATOM   1874 N  N   . THR A 1 277 ? -7.074  -26.520 -14.501 1.00 48.22  ? 540  THR A N   1 
ATOM   1875 C  CA  . THR A 1 277 ? -6.272  -25.492 -13.758 1.00 47.06  ? 540  THR A CA  1 
ATOM   1876 C  C   . THR A 1 277 ? -5.376  -24.651 -14.673 1.00 44.46  ? 540  THR A C   1 
ATOM   1877 O  O   . THR A 1 277 ? -4.951  -23.590 -14.219 1.00 52.06  ? 540  THR A O   1 
ATOM   1878 C  CB  . THR A 1 277 ? -5.451  -26.067 -12.595 1.00 48.90  ? 540  THR A CB  1 
ATOM   1879 O  OG1 . THR A 1 277 ? -4.442  -26.955 -13.067 1.00 56.92  ? 540  THR A OG1 1 
ATOM   1880 C  CG2 . THR A 1 277 ? -6.333  -26.801 -11.613 1.00 54.74  ? 540  THR A CG2 1 
ATOM   1881 N  N   . ARG A 1 278 ? -5.134  -25.102 -15.914 0.50 44.87  ? 541  ARG A N   1 
ATOM   1882 C  CA  . ARG A 1 278 ? -4.181  -24.485 -16.881 0.50 44.02  ? 541  ARG A CA  1 
ATOM   1883 C  C   . ARG A 1 278 ? -4.918  -23.690 -17.957 0.50 43.12  ? 541  ARG A C   1 
ATOM   1884 O  O   . ARG A 1 278 ? -4.247  -23.280 -18.924 0.50 42.98  ? 541  ARG A O   1 
ATOM   1885 C  CB  . ARG A 1 278 ? -3.362  -25.556 -17.607 0.50 47.62  ? 541  ARG A CB  1 
ATOM   1886 C  CG  . ARG A 1 278 ? -2.698  -26.559 -16.681 0.50 51.48  ? 541  ARG A CG  1 
ATOM   1887 C  CD  . ARG A 1 278 ? -1.434  -26.004 -16.074 0.50 55.67  ? 541  ARG A CD  1 
ATOM   1888 N  NE  . ARG A 1 278 ? -0.887  -26.917 -15.083 0.50 63.58  ? 541  ARG A NE  1 
ATOM   1889 C  CZ  . ARG A 1 278 ? 0.400   -27.016 -14.788 0.50 61.06  ? 541  ARG A CZ  1 
ATOM   1890 N  NH1 . ARG A 1 278 ? 1.280   -26.271 -15.435 0.50 60.38  ? 541  ARG A NH1 1 
ATOM   1891 N  NH2 . ARG A 1 278 ? 0.799   -27.866 -13.859 0.50 63.58  ? 541  ARG A NH2 1 
ATOM   1892 N  N   . ILE A 1 279 ? -6.243  -23.549 -17.845 0.50 43.73  ? 542  ILE A N   1 
ATOM   1893 C  CA  . ILE A 1 279 ? -7.051  -22.717 -18.787 0.50 44.32  ? 542  ILE A CA  1 
ATOM   1894 C  C   . ILE A 1 279 ? -6.804  -21.248 -18.418 0.50 43.25  ? 542  ILE A C   1 
ATOM   1895 O  O   . ILE A 1 279 ? -7.087  -20.856 -17.270 0.50 42.24  ? 542  ILE A O   1 
ATOM   1896 C  CB  . ILE A 1 279 ? -8.541  -23.126 -18.763 0.50 46.10  ? 542  ILE A CB  1 
ATOM   1897 C  CG1 . ILE A 1 279 ? -8.767  -24.451 -19.494 0.50 46.39  ? 542  ILE A CG1 1 
ATOM   1898 C  CG2 . ILE A 1 279 ? -9.430  -22.036 -19.344 0.50 44.76  ? 542  ILE A CG2 1 
ATOM   1899 C  CD1 . ILE A 1 279 ? -8.580  -24.346 -20.988 0.50 46.44  ? 542  ILE A CD1 1 
ATOM   1900 N  N   . THR A 1 280 ? -6.208  -20.492 -19.337 0.50 44.30  ? 543  THR A N   1 
ATOM   1901 C  CA  . THR A 1 280 ? -5.800  -19.077 -19.144 0.50 45.56  ? 543  THR A CA  1 
ATOM   1902 C  C   . THR A 1 280 ? -6.995  -18.172 -19.462 0.50 48.33  ? 543  THR A C   1 
ATOM   1903 O  O   . THR A 1 280 ? -7.938  -18.662 -20.124 0.50 45.36  ? 543  THR A O   1 
ATOM   1904 C  CB  . THR A 1 280 ? -4.594  -18.744 -20.025 0.50 43.08  ? 543  THR A CB  1 
ATOM   1905 O  OG1 . THR A 1 280 ? -5.019  -18.793 -21.387 0.50 41.49  ? 543  THR A OG1 1 
ATOM   1906 C  CG2 . THR A 1 280 ? -3.442  -19.700 -19.813 0.50 44.86  ? 543  THR A CG2 1 
ATOM   1907 N  N   . LEU A 1 281 ? -6.989  -16.937 -18.954 0.50 49.80  ? 544  LEU A N   1 
ATOM   1908 C  CA  . LEU A 1 281 ? -7.983  -15.907 -19.349 0.50 52.31  ? 544  LEU A CA  1 
ATOM   1909 C  C   . LEU A 1 281 ? -7.897  -15.759 -20.872 0.50 48.29  ? 544  LEU A C   1 
ATOM   1910 O  O   . LEU A 1 281 ? -8.930  -15.512 -21.507 0.50 44.08  ? 544  LEU A O   1 
ATOM   1911 C  CB  . LEU A 1 281 ? -7.689  -14.587 -18.630 0.50 58.17  ? 544  LEU A CB  1 
ATOM   1912 C  CG  . LEU A 1 281 ? -8.613  -13.427 -19.007 0.50 61.90  ? 544  LEU A CG  1 
ATOM   1913 C  CD1 . LEU A 1 281 ? -10.079 -13.833 -18.901 0.50 60.04  ? 544  LEU A CD1 1 
ATOM   1914 C  CD2 . LEU A 1 281 ? -8.337  -12.204 -18.144 0.50 63.87  ? 544  LEU A CD2 1 
ATOM   1915 N  N   . GLU A 1 282 ? -6.698  -15.960 -21.424 0.50 46.75  ? 545  GLU A N   1 
ATOM   1916 C  CA  . GLU A 1 282 ? -6.420  -15.902 -22.884 0.50 46.52  ? 545  GLU A CA  1 
ATOM   1917 C  C   . GLU A 1 282 ? -7.242  -16.990 -23.594 0.50 46.78  ? 545  GLU A C   1 
ATOM   1918 O  O   . GLU A 1 282 ? -7.671  -16.769 -24.750 0.50 47.34  ? 545  GLU A O   1 
ATOM   1919 C  CB  . GLU A 1 282 ? -4.917  -16.064 -23.103 0.50 48.40  ? 545  GLU A CB  1 
ATOM   1920 C  CG  . GLU A 1 282 ? -4.328  -15.054 -24.064 0.50 48.47  ? 545  GLU A CG  1 
ATOM   1921 C  CD  . GLU A 1 282 ? -4.629  -13.609 -23.718 0.50 48.23  ? 545  GLU A CD  1 
ATOM   1922 O  OE1 . GLU A 1 282 ? -4.486  -13.233 -22.532 0.50 52.20  ? 545  GLU A OE1 1 
ATOM   1923 O  OE2 . GLU A 1 282 ? -5.012  -12.865 -24.636 0.50 47.34  ? 545  GLU A OE2 1 
ATOM   1924 N  N   . ASP A 1 283 ? -7.471  -18.114 -22.908 0.50 45.94  ? 546  ASP A N   1 
ATOM   1925 C  CA  . ASP A 1 283 ? -8.265  -19.267 -23.413 0.50 44.01  ? 546  ASP A CA  1 
ATOM   1926 C  C   . ASP A 1 283 ? -9.761  -18.952 -23.257 0.50 42.41  ? 546  ASP A C   1 
ATOM   1927 O  O   . ASP A 1 283 ? -10.538 -19.250 -24.193 0.50 39.81  ? 546  ASP A O   1 
ATOM   1928 C  CB  . ASP A 1 283 ? -7.887  -20.560 -22.682 0.50 43.21  ? 546  ASP A CB  1 
ATOM   1929 C  CG  . ASP A 1 283 ? -6.517  -21.123 -23.048 0.50 42.28  ? 546  ASP A CG  1 
ATOM   1930 O  OD1 . ASP A 1 283 ? -6.137  -21.042 -24.231 0.50 41.26  ? 546  ASP A OD1 1 
ATOM   1931 O  OD2 . ASP A 1 283 ? -5.842  -21.648 -22.143 0.50 41.43  ? 546  ASP A OD2 1 
ATOM   1932 N  N   . LEU A 1 284 ? -10.153 -18.372 -22.120 0.50 41.64  ? 547  LEU A N   1 
ATOM   1933 C  CA  . LEU A 1 284 ? -11.576 -18.079 -21.786 0.50 42.27  ? 547  LEU A CA  1 
ATOM   1934 C  C   . LEU A 1 284 ? -12.142 -16.996 -22.719 0.50 43.18  ? 547  LEU A C   1 
ATOM   1935 O  O   . LEU A 1 284 ? -13.380 -16.892 -22.805 0.50 46.86  ? 547  LEU A O   1 
ATOM   1936 C  CB  . LEU A 1 284 ? -11.669 -17.666 -20.314 0.50 42.50  ? 547  LEU A CB  1 
ATOM   1937 C  CG  . LEU A 1 284 ? -11.605 -18.821 -19.310 0.50 42.78  ? 547  LEU A CG  1 
ATOM   1938 C  CD1 . LEU A 1 284 ? -11.739 -18.324 -17.877 0.50 42.86  ? 547  LEU A CD1 1 
ATOM   1939 C  CD2 . LEU A 1 284 ? -12.676 -19.862 -19.600 0.50 41.57  ? 547  LEU A CD2 1 
ATOM   1940 N  N   . LYS A 1 285 ? -11.273 -16.252 -23.412 0.50 47.59  ? 548  LYS A N   1 
ATOM   1941 C  CA  . LYS A 1 285 ? -11.636 -15.153 -24.349 0.50 49.43  ? 548  LYS A CA  1 
ATOM   1942 C  C   . LYS A 1 285 ? -11.700 -15.681 -25.787 0.50 47.11  ? 548  LYS A C   1 
ATOM   1943 O  O   . LYS A 1 285 ? -12.593 -15.237 -26.530 0.50 49.02  ? 548  LYS A O   1 
ATOM   1944 C  CB  . LYS A 1 285 ? -10.650 -13.984 -24.236 0.50 52.78  ? 548  LYS A CB  1 
ATOM   1945 C  CG  . LYS A 1 285 ? -10.934 -13.022 -23.088 0.50 57.31  ? 548  LYS A CG  1 
ATOM   1946 C  CD  . LYS A 1 285 ? -10.297 -11.655 -23.257 0.50 62.50  ? 548  LYS A CD  1 
ATOM   1947 C  CE  . LYS A 1 285 ? -10.850 -10.613 -22.305 0.50 63.72  ? 548  LYS A CE  1 
ATOM   1948 N  NZ  . LYS A 1 285 ? -10.264 -9.277  -22.568 0.50 68.20  ? 548  LYS A NZ  1 
ATOM   1949 N  N   . ASN A 1 286 ? -10.790 -16.575 -26.176 1.00 42.90  ? 549  ASN A N   1 
ATOM   1950 C  CA  . ASN A 1 286 ? -10.871 -17.244 -27.500 1.00 43.34  ? 549  ASN A CA  1 
ATOM   1951 C  C   . ASN A 1 286 ? -12.125 -18.141 -27.590 1.00 41.47  ? 549  ASN A C   1 
ATOM   1952 O  O   . ASN A 1 286 ? -12.710 -18.265 -28.678 1.00 40.23  ? 549  ASN A O   1 
ATOM   1953 C  CB  . ASN A 1 286 ? -9.594  -18.010 -27.804 1.00 47.38  ? 549  ASN A CB  1 
ATOM   1954 C  CG  . ASN A 1 286 ? -8.408  -17.076 -27.984 1.00 50.63  ? 549  ASN A CG  1 
ATOM   1955 O  OD1 . ASN A 1 286 ? -8.509  -16.017 -28.601 1.00 43.13  ? 549  ASN A OD1 1 
ATOM   1956 N  ND2 . ASN A 1 286 ? -7.259  -17.491 -27.502 1.00 53.70  ? 549  ASN A ND2 1 
ATOM   1957 N  N   . GLU A 1 287 ? -12.525 -18.743 -26.467 0.50 41.77  ? 550  GLU A N   1 
ATOM   1958 C  CA  . GLU A 1 287 ? -13.770 -19.553 -26.357 0.50 42.77  ? 550  GLU A CA  1 
ATOM   1959 C  C   . GLU A 1 287 ? -14.982 -18.629 -26.559 0.50 41.78  ? 550  GLU A C   1 
ATOM   1960 O  O   . GLU A 1 287 ? -15.888 -19.018 -27.316 0.50 42.26  ? 550  GLU A O   1 
ATOM   1961 C  CB  . GLU A 1 287 ? -13.784 -20.302 -25.021 0.50 42.76  ? 550  GLU A CB  1 
ATOM   1962 C  CG  . GLU A 1 287 ? -12.865 -21.513 -25.022 0.50 44.71  ? 550  GLU A CG  1 
ATOM   1963 C  CD  . GLU A 1 287 ? -12.332 -21.957 -23.668 0.50 47.16  ? 550  GLU A CD  1 
ATOM   1964 O  OE1 . GLU A 1 287 ? -13.060 -21.816 -22.658 0.50 47.41  ? 550  GLU A OE1 1 
ATOM   1965 O  OE2 . GLU A 1 287 ? -11.187 -22.457 -23.627 0.50 49.20  ? 550  GLU A OE2 1 
ATOM   1966 N  N   . GLU A 1 288 ? -14.954 -17.435 -25.958 0.50 41.29  ? 551  GLU A N   1 
ATOM   1967 C  CA  . GLU A 1 288 ? -16.027 -16.404 -26.023 0.50 41.99  ? 551  GLU A CA  1 
ATOM   1968 C  C   . GLU A 1 288 ? -16.343 -16.044 -27.480 0.50 41.40  ? 551  GLU A C   1 
ATOM   1969 O  O   . GLU A 1 288 ? -17.485 -15.633 -27.738 0.50 45.73  ? 551  GLU A O   1 
ATOM   1970 C  CB  . GLU A 1 288 ? -15.617 -15.146 -25.251 0.50 44.71  ? 551  GLU A CB  1 
ATOM   1971 C  CG  . GLU A 1 288 ? -16.777 -14.206 -24.927 0.50 47.89  ? 551  GLU A CG  1 
ATOM   1972 C  CD  . GLU A 1 288 ? -16.914 -12.957 -25.794 0.50 47.58  ? 551  GLU A CD  1 
ATOM   1973 O  OE1 . GLU A 1 288 ? -16.201 -12.865 -26.812 0.50 46.68  ? 551  GLU A OE1 1 
ATOM   1974 O  OE2 . GLU A 1 288 ? -17.734 -12.068 -25.441 0.50 46.37  ? 551  GLU A OE2 1 
ATOM   1975 N  N   . MET A 1 289 ? -15.396 -16.213 -28.404 0.50 40.38  ? 552  MET A N   1 
ATOM   1976 C  CA  . MET A 1 289 ? -15.552 -15.760 -29.812 0.50 41.22  ? 552  MET A CA  1 
ATOM   1977 C  C   . MET A 1 289 ? -16.616 -16.605 -30.529 0.50 41.56  ? 552  MET A C   1 
ATOM   1978 O  O   . MET A 1 289 ? -16.949 -16.275 -31.688 0.50 42.09  ? 552  MET A O   1 
ATOM   1979 C  CB  . MET A 1 289 ? -14.219 -15.814 -30.569 0.50 42.81  ? 552  MET A CB  1 
ATOM   1980 C  CG  . MET A 1 289 ? -13.140 -14.941 -29.924 0.50 45.95  ? 552  MET A CG  1 
ATOM   1981 S  SD  . MET A 1 289 ? -11.658 -14.628 -30.949 0.50 51.48  ? 552  MET A SD  1 
ATOM   1982 C  CE  . MET A 1 289 ? -11.718 -16.002 -32.098 0.50 49.90  ? 552  MET A CE  1 
ATOM   1983 N  N   . VAL A 1 290 ? -17.144 -17.651 -29.884 1.00 41.15  ? 553  VAL A N   1 
ATOM   1984 C  CA  . VAL A 1 290 ? -18.351 -18.372 -30.401 1.00 39.73  ? 553  VAL A CA  1 
ATOM   1985 C  C   . VAL A 1 290 ? -19.552 -17.392 -30.445 1.00 37.86  ? 553  VAL A C   1 
ATOM   1986 O  O   . VAL A 1 290 ? -20.349 -17.548 -31.362 1.00 40.49  ? 553  VAL A O   1 
ATOM   1987 C  CB  . VAL A 1 290 ? -18.696 -19.646 -29.612 1.00 34.43  ? 553  VAL A CB  1 
ATOM   1988 C  CG1 . VAL A 1 290 ? -19.130 -19.353 -28.182 1.00 35.66  ? 553  VAL A CG1 1 
ATOM   1989 C  CG2 . VAL A 1 290 ? -19.749 -20.466 -30.337 1.00 39.73  ? 553  VAL A CG2 1 
ATOM   1990 N  N   . THR A 1 291 ? -19.656 -16.398 -29.546 1.00 37.14  ? 554  THR A N   1 
ATOM   1991 C  CA  . THR A 1 291 ? -20.743 -15.367 -29.565 1.00 42.48  ? 554  THR A CA  1 
ATOM   1992 C  C   . THR A 1 291 ? -20.782 -14.565 -30.881 1.00 45.72  ? 554  THR A C   1 
ATOM   1993 O  O   . THR A 1 291 ? -21.890 -14.105 -31.275 1.00 47.79  ? 554  THR A O   1 
ATOM   1994 C  CB  . THR A 1 291 ? -20.654 -14.376 -28.411 1.00 39.31  ? 554  THR A CB  1 
ATOM   1995 O  OG1 . THR A 1 291 ? -19.363 -13.779 -28.504 1.00 41.84  ? 554  THR A OG1 1 
ATOM   1996 C  CG2 . THR A 1 291 ? -20.815 -15.029 -27.062 1.00 41.72  ? 554  THR A CG2 1 
ATOM   1997 N  N   . ASN A 1 292 ? -19.622 -14.395 -31.529 0.50 45.65  ? 555  ASN A N   1 
ATOM   1998 C  CA  . ASN A 1 292 ? -19.480 -13.759 -32.871 0.50 47.04  ? 555  ASN A CA  1 
ATOM   1999 C  C   . ASN A 1 292 ? -20.481 -14.358 -33.865 0.50 48.85  ? 555  ASN A C   1 
ATOM   2000 O  O   . ASN A 1 292 ? -20.886 -13.629 -34.793 0.50 50.28  ? 555  ASN A O   1 
ATOM   2001 C  CB  . ASN A 1 292 ? -18.091 -13.947 -33.488 0.50 46.06  ? 555  ASN A CB  1 
ATOM   2002 C  CG  . ASN A 1 292 ? -17.062 -12.959 -32.980 0.50 46.38  ? 555  ASN A CG  1 
ATOM   2003 O  OD1 . ASN A 1 292 ? -17.399 -11.984 -32.312 0.50 48.03  ? 555  ASN A OD1 1 
ATOM   2004 N  ND2 . ASN A 1 292 ? -15.802 -13.207 -33.301 0.50 45.90  ? 555  ASN A ND2 1 
ATOM   2005 N  N   . HIS A 1 293 ? -20.856 -15.629 -33.686 1.00 47.64  ? 556  HIS A N   1 
ATOM   2006 C  CA  . HIS A 1 293 ? -21.661 -16.397 -34.683 1.00 48.96  ? 556  HIS A CA  1 
ATOM   2007 C  C   . HIS A 1 293 ? -23.143 -16.335 -34.310 1.00 43.17  ? 556  HIS A C   1 
ATOM   2008 O  O   . HIS A 1 293 ? -23.965 -16.996 -34.985 1.00 43.59  ? 556  HIS A O   1 
ATOM   2009 C  CB  . HIS A 1 293 ? -21.066 -17.811 -34.849 1.00 52.14  ? 556  HIS A CB  1 
ATOM   2010 C  CG  . HIS A 1 293 ? -19.646 -17.772 -35.317 1.00 51.74  ? 556  HIS A CG  1 
ATOM   2011 N  ND1 . HIS A 1 293 ? -19.296 -18.010 -36.626 1.00 49.62  ? 556  HIS A ND1 1 
ATOM   2012 C  CD2 . HIS A 1 293 ? -18.493 -17.469 -34.667 1.00 55.62  ? 556  HIS A CD2 1 
ATOM   2013 C  CE1 . HIS A 1 293 ? -17.992 -17.856 -36.764 1.00 47.78  ? 556  HIS A CE1 1 
ATOM   2014 N  NE2 . HIS A 1 293 ? -17.475 -17.514 -35.585 1.00 46.77  ? 556  HIS A NE2 1 
ATOM   2015 N  N   . MET A 1 294 ? -23.430 -15.622 -33.224 1.00 43.18  ? 557  MET A N   1 
ATOM   2016 C  CA  . MET A 1 294 ? -24.804 -15.572 -32.679 1.00 48.71  ? 557  MET A CA  1 
ATOM   2017 C  C   . MET A 1 294 ? -25.463 -14.236 -33.011 1.00 52.05  ? 557  MET A C   1 
ATOM   2018 O  O   . MET A 1 294 ? -24.832 -13.415 -33.682 1.00 49.47  ? 557  MET A O   1 
ATOM   2019 C  CB  . MET A 1 294 ? -24.766 -15.720 -31.157 1.00 49.74  ? 557  MET A CB  1 
ATOM   2020 C  CG  . MET A 1 294 ? -24.087 -16.981 -30.669 1.00 50.84  ? 557  MET A CG  1 
ATOM   2021 S  SD  . MET A 1 294 ? -24.126 -17.088 -28.867 1.00 46.32  ? 557  MET A SD  1 
ATOM   2022 C  CE  . MET A 1 294 ? -23.065 -18.505 -28.597 1.00 50.68  ? 557  MET A CE  1 
ATOM   2023 N  N   . GLU A 1 295 ? -26.690 -14.051 -32.529 0.50 55.71  ? 558  GLU A N   1 
ATOM   2024 C  CA  . GLU A 1 295 ? -27.444 -12.818 -32.844 0.50 59.24  ? 558  GLU A CA  1 
ATOM   2025 C  C   . GLU A 1 295 ? -28.551 -12.608 -31.817 0.50 56.00  ? 558  GLU A C   1 
ATOM   2026 O  O   . GLU A 1 295 ? -28.921 -13.581 -31.139 0.50 57.27  ? 558  GLU A O   1 
ATOM   2027 C  CB  . GLU A 1 295 ? -28.075 -12.952 -34.227 0.50 60.33  ? 558  GLU A CB  1 
ATOM   2028 C  CG  . GLU A 1 295 ? -29.195 -13.972 -34.280 0.50 62.41  ? 558  GLU A CG  1 
ATOM   2029 C  CD  . GLU A 1 295 ? -29.767 -14.198 -35.668 0.50 66.26  ? 558  GLU A CD  1 
ATOM   2030 O  OE1 . GLU A 1 295 ? -29.061 -13.902 -36.652 0.50 62.64  ? 558  GLU A OE1 1 
ATOM   2031 O  OE2 . GLU A 1 295 ? -30.918 -14.662 -35.759 0.50 70.38  ? 558  GLU A OE2 1 
ATOM   2032 N  N   . GLY A 1 296 ? -29.039 -11.377 -31.696 1.00 59.22  ? 559  GLY A N   1 
ATOM   2033 C  CA  . GLY A 1 296 ? -30.189 -11.094 -30.819 1.00 54.99  ? 559  GLY A CA  1 
ATOM   2034 C  C   . GLY A 1 296 ? -29.929 -11.321 -29.349 1.00 54.83  ? 559  GLY A C   1 
ATOM   2035 O  O   . GLY A 1 296 ? -28.786 -11.114 -28.919 1.00 52.29  ? 559  GLY A O   1 
ATOM   2036 N  N   . GLU A 1 297 ? -30.965 -11.731 -28.618 0.50 50.76  ? 560  GLU A N   1 
ATOM   2037 C  CA  . GLU A 1 297 ? -30.854 -11.963 -27.158 0.50 54.86  ? 560  GLU A CA  1 
ATOM   2038 C  C   . GLU A 1 297 ? -29.813 -13.052 -26.881 0.50 54.00  ? 560  GLU A C   1 
ATOM   2039 O  O   . GLU A 1 297 ? -29.115 -12.946 -25.863 0.50 50.05  ? 560  GLU A O   1 
ATOM   2040 C  CB  . GLU A 1 297 ? -32.229 -12.363 -26.623 0.50 56.53  ? 560  GLU A CB  1 
ATOM   2041 C  CG  . GLU A 1 297 ? -32.285 -12.515 -25.117 0.50 61.96  ? 560  GLU A CG  1 
ATOM   2042 C  CD  . GLU A 1 297 ? -33.679 -12.815 -24.595 0.50 65.98  ? 560  GLU A CD  1 
ATOM   2043 O  OE1 . GLU A 1 297 ? -34.618 -12.834 -25.412 0.50 65.44  ? 560  GLU A OE1 1 
ATOM   2044 O  OE2 . GLU A 1 297 ? -33.821 -13.030 -23.376 0.50 73.18  ? 560  GLU A OE2 1 
ATOM   2045 N  N   . HIS A 1 298 ? -29.723 -14.057 -27.753 0.50 53.01  ? 561  HIS A N   1 
ATOM   2046 C  CA  . HIS A 1 298 ? -28.783 -15.186 -27.530 0.50 51.94  ? 561  HIS A CA  1 
ATOM   2047 C  C   . HIS A 1 298 ? -27.364 -14.640 -27.368 0.50 50.57  ? 561  HIS A C   1 
ATOM   2048 O  O   . HIS A 1 298 ? -26.711 -15.001 -26.380 0.50 48.38  ? 561  HIS A O   1 
ATOM   2049 C  CB  . HIS A 1 298 ? -28.891 -16.195 -28.679 0.50 50.42  ? 561  HIS A CB  1 
ATOM   2050 C  CG  . HIS A 1 298 ? -28.090 -17.437 -28.483 0.50 49.64  ? 561  HIS A CG  1 
ATOM   2051 N  ND1 . HIS A 1 298 ? -27.643 -18.199 -29.543 0.50 48.11  ? 561  HIS A ND1 1 
ATOM   2052 C  CD2 . HIS A 1 298 ? -27.657 -18.055 -27.364 0.50 47.55  ? 561  HIS A CD2 1 
ATOM   2053 C  CE1 . HIS A 1 298 ? -26.969 -19.232 -29.087 0.50 50.07  ? 561  HIS A CE1 1 
ATOM   2054 N  NE2 . HIS A 1 298 ? -26.964 -19.167 -27.754 0.50 50.01  ? 561  HIS A NE2 1 
ATOM   2055 N  N   . LYS A 1 299 ? -26.933 -13.777 -28.286 0.50 48.29  ? 562  LYS A N   1 
ATOM   2056 C  CA  . LYS A 1 299 ? -25.547 -13.249 -28.241 0.50 50.53  ? 562  LYS A CA  1 
ATOM   2057 C  C   . LYS A 1 299 ? -25.318 -12.584 -26.883 0.50 53.75  ? 562  LYS A C   1 
ATOM   2058 O  O   . LYS A 1 299 ? -24.271 -12.843 -26.275 0.50 56.76  ? 562  LYS A O   1 
ATOM   2059 C  CB  . LYS A 1 299 ? -25.322 -12.271 -29.398 0.50 50.04  ? 562  LYS A CB  1 
ATOM   2060 C  CG  . LYS A 1 299 ? -23.915 -11.706 -29.525 0.50 50.02  ? 562  LYS A CG  1 
ATOM   2061 C  CD  . LYS A 1 299 ? -23.773 -10.756 -30.694 0.50 52.17  ? 562  LYS A CD  1 
ATOM   2062 C  CE  . LYS A 1 299 ? -22.397 -10.137 -30.810 0.50 53.26  ? 562  LYS A CE  1 
ATOM   2063 N  NZ  . LYS A 1 299 ? -21.373 -11.137 -31.193 0.50 56.43  ? 562  LYS A NZ  1 
ATOM   2064 N  N   . LYS A 1 300 ? -26.280 -11.785 -26.419 0.50 55.69  ? 563  LYS A N   1 
ATOM   2065 C  CA  . LYS A 1 300 ? -26.119 -11.048 -25.138 0.50 56.94  ? 563  LYS A CA  1 
ATOM   2066 C  C   . LYS A 1 300 ? -26.102 -12.030 -23.965 0.50 50.23  ? 563  LYS A C   1 
ATOM   2067 O  O   . LYS A 1 300 ? -25.243 -11.873 -23.085 0.50 52.18  ? 563  LYS A O   1 
ATOM   2068 C  CB  . LYS A 1 300 ? -27.238 -10.015 -24.979 0.50 63.21  ? 563  LYS A CB  1 
ATOM   2069 C  CG  . LYS A 1 300 ? -27.300 -8.966  -26.080 0.50 67.35  ? 563  LYS A CG  1 
ATOM   2070 C  CD  . LYS A 1 300 ? -25.988 -8.236  -26.265 0.50 71.88  ? 563  LYS A CD  1 
ATOM   2071 C  CE  . LYS A 1 300 ? -25.976 -7.328  -27.476 0.50 75.55  ? 563  LYS A CE  1 
ATOM   2072 N  NZ  . LYS A 1 300 ? -24.696 -6.590  -27.593 0.50 74.58  ? 563  LYS A NZ  1 
ATOM   2073 N  N   . LEU A 1 301 ? -27.014 -13.001 -23.966 0.50 48.37  ? 564  LEU A N   1 
ATOM   2074 C  CA  . LEU A 1 301 ? -27.089 -13.986 -22.856 0.50 50.18  ? 564  LEU A CA  1 
ATOM   2075 C  C   . LEU A 1 301 ? -25.779 -14.780 -22.791 0.50 50.57  ? 564  LEU A C   1 
ATOM   2076 O  O   . LEU A 1 301 ? -25.268 -14.973 -21.678 0.50 46.22  ? 564  LEU A O   1 
ATOM   2077 C  CB  . LEU A 1 301 ? -28.290 -14.905 -23.097 0.50 49.91  ? 564  LEU A CB  1 
ATOM   2078 C  CG  . LEU A 1 301 ? -29.665 -14.256 -22.943 0.50 50.01  ? 564  LEU A CG  1 
ATOM   2079 C  CD1 . LEU A 1 301 ? -30.767 -15.222 -23.347 0.50 48.90  ? 564  LEU A CD1 1 
ATOM   2080 C  CD2 . LEU A 1 301 ? -29.878 -13.776 -21.517 0.50 50.87  ? 564  LEU A CD2 1 
ATOM   2081 N  N   . ALA A 1 302 ? -25.256 -15.204 -23.944 1.00 48.84  ? 565  ALA A N   1 
ATOM   2082 C  CA  . ALA A 1 302 ? -23.993 -15.974 -24.002 1.00 48.64  ? 565  ALA A CA  1 
ATOM   2083 C  C   . ALA A 1 302 ? -22.818 -15.090 -23.586 1.00 51.93  ? 565  ALA A C   1 
ATOM   2084 O  O   . ALA A 1 302 ? -21.946 -15.580 -22.866 1.00 53.91  ? 565  ALA A O   1 
ATOM   2085 C  CB  . ALA A 1 302 ? -23.799 -16.511 -25.390 1.00 43.73  ? 565  ALA A CB  1 
ATOM   2086 N  N   . GLU A 1 303 ? -22.805 -13.836 -24.037 0.50 51.73  ? 566  GLU A N   1 
ATOM   2087 C  CA  . GLU A 1 303 ? -21.717 -12.896 -23.668 0.50 50.84  ? 566  GLU A CA  1 
ATOM   2088 C  C   . GLU A 1 303 ? -21.720 -12.724 -22.148 0.50 49.05  ? 566  GLU A C   1 
ATOM   2089 O  O   . GLU A 1 303 ? -20.633 -12.592 -21.569 0.50 47.68  ? 566  GLU A O   1 
ATOM   2090 C  CB  . GLU A 1 303 ? -21.905 -11.563 -24.392 0.50 51.31  ? 566  GLU A CB  1 
ATOM   2091 C  CG  . GLU A 1 303 ? -21.541 -11.618 -25.862 0.50 53.82  ? 566  GLU A CG  1 
ATOM   2092 C  CD  . GLU A 1 303 ? -21.966 -10.394 -26.651 0.50 54.71  ? 566  GLU A CD  1 
ATOM   2093 O  OE1 . GLU A 1 303 ? -22.776 -9.610  -26.126 0.50 58.68  ? 566  GLU A OE1 1 
ATOM   2094 O  OE2 . GLU A 1 303 ? -21.482 -10.226 -27.784 0.50 57.57  ? 566  GLU A OE2 1 
ATOM   2095 N  N   . ALA A 1 304 ? -22.906 -12.746 -21.541 0.50 46.67  ? 567  ALA A N   1 
ATOM   2096 C  CA  . ALA A 1 304 ? -23.021 -12.585 -20.075 0.50 48.40  ? 567  ALA A CA  1 
ATOM   2097 C  C   . ALA A 1 304 ? -22.490 -13.836 -19.365 0.50 45.77  ? 567  ALA A C   1 
ATOM   2098 O  O   . ALA A 1 304 ? -21.722 -13.677 -18.407 0.50 39.20  ? 567  ALA A O   1 
ATOM   2099 C  CB  . ALA A 1 304 ? -24.454 -12.299 -19.706 0.50 47.82  ? 567  ALA A CB  1 
ATOM   2100 N  N   . ILE A 1 305 ? -22.886 -15.027 -19.821 0.50 47.91  ? 568  ILE A N   1 
ATOM   2101 C  CA  . ILE A 1 305 ? -22.359 -16.286 -19.222 0.50 47.80  ? 568  ILE A CA  1 
ATOM   2102 C  C   . ILE A 1 305 ? -20.829 -16.188 -19.219 0.50 46.35  ? 568  ILE A C   1 
ATOM   2103 O  O   . ILE A 1 305 ? -20.233 -16.393 -18.154 0.50 45.49  ? 568  ILE A O   1 
ATOM   2104 C  CB  . ILE A 1 305 ? -22.863 -17.528 -19.984 0.50 51.52  ? 568  ILE A CB  1 
ATOM   2105 C  CG1 . ILE A 1 305 ? -24.370 -17.740 -19.794 0.50 49.32  ? 568  ILE A CG1 1 
ATOM   2106 C  CG2 . ILE A 1 305 ? -22.058 -18.766 -19.595 0.50 49.98  ? 568  ILE A CG2 1 
ATOM   2107 C  CD1 . ILE A 1 305 ? -24.832 -17.673 -18.354 0.50 48.56  ? 568  ILE A CD1 1 
ATOM   2108 N  N   . PHE A 1 306 ? -20.237 -15.854 -20.371 1.00 45.45  ? 569  PHE A N   1 
ATOM   2109 C  CA  . PHE A 1 306 ? -18.765 -15.788 -20.577 1.00 51.97  ? 569  PHE A CA  1 
ATOM   2110 C  C   . PHE A 1 306 ? -18.103 -14.699 -19.702 1.00 61.26  ? 569  PHE A C   1 
ATOM   2111 O  O   . PHE A 1 306 ? -17.103 -14.990 -19.029 1.00 61.72  ? 569  PHE A O   1 
ATOM   2112 C  CB  . PHE A 1 306 ? -18.400 -15.589 -22.050 1.00 50.18  ? 569  PHE A CB  1 
ATOM   2113 C  CG  . PHE A 1 306 ? -18.309 -16.860 -22.859 1.00 54.19  ? 569  PHE A CG  1 
ATOM   2114 C  CD1 . PHE A 1 306 ? -17.298 -17.780 -22.626 1.00 56.32  ? 569  PHE A CD1 1 
ATOM   2115 C  CD2 . PHE A 1 306 ? -19.215 -17.134 -23.867 1.00 51.18  ? 569  PHE A CD2 1 
ATOM   2116 C  CE1 . PHE A 1 306 ? -17.228 -18.947 -23.368 1.00 53.06  ? 569  PHE A CE1 1 
ATOM   2117 C  CE2 . PHE A 1 306 ? -19.141 -18.305 -24.607 1.00 51.53  ? 569  PHE A CE2 1 
ATOM   2118 C  CZ  . PHE A 1 306 ? -18.152 -19.217 -24.344 1.00 52.49  ? 569  PHE A CZ  1 
ATOM   2119 N  N   . LYS A 1 307 ? -18.650 -13.478 -19.769 0.50 61.05  ? 570  LYS A N   1 
ATOM   2120 C  CA  . LYS A 1 307 ? -18.185 -12.256 -19.055 0.50 58.68  ? 570  LYS A CA  1 
ATOM   2121 C  C   . LYS A 1 307 ? -18.247 -12.461 -17.538 0.50 53.84  ? 570  LYS A C   1 
ATOM   2122 O  O   . LYS A 1 307 ? -17.251 -12.149 -16.861 0.50 54.93  ? 570  LYS A O   1 
ATOM   2123 C  CB  . LYS A 1 307 ? -19.069 -11.056 -19.418 0.50 63.34  ? 570  LYS A CB  1 
ATOM   2124 C  CG  . LYS A 1 307 ? -18.445 -10.000 -20.324 0.50 65.59  ? 570  LYS A CG  1 
ATOM   2125 C  CD  . LYS A 1 307 ? -19.172 -8.661  -20.248 0.50 71.37  ? 570  LYS A CD  1 
ATOM   2126 C  CE  . LYS A 1 307 ? -18.454 -7.519  -20.942 0.50 72.76  ? 570  LYS A CE  1 
ATOM   2127 N  NZ  . LYS A 1 307 ? -18.949 -7.308  -22.324 0.50 72.65  ? 570  LYS A NZ  1 
ATOM   2128 N  N   . LEU A 1 308 ? -19.374 -12.966 -17.029 0.50 51.11  ? 571  LEU A N   1 
ATOM   2129 C  CA  . LEU A 1 308 ? -19.754 -12.854 -15.594 0.50 50.67  ? 571  LEU A CA  1 
ATOM   2130 C  C   . LEU A 1 308 ? -19.418 -14.136 -14.819 0.50 51.03  ? 571  LEU A C   1 
ATOM   2131 O  O   . LEU A 1 308 ? -18.894 -14.004 -13.699 0.50 50.80  ? 571  LEU A O   1 
ATOM   2132 C  CB  . LEU A 1 308 ? -21.252 -12.538 -15.506 0.50 52.14  ? 571  LEU A CB  1 
ATOM   2133 C  CG  . LEU A 1 308 ? -21.723 -11.355 -16.354 0.50 52.90  ? 571  LEU A CG  1 
ATOM   2134 C  CD1 . LEU A 1 308 ? -23.241 -11.238 -16.324 0.50 51.89  ? 571  LEU A CD1 1 
ATOM   2135 C  CD2 . LEU A 1 308 ? -21.070 -10.055 -15.900 0.50 51.36  ? 571  LEU A CD2 1 
ATOM   2136 N  N   . THR A 1 309 ? -19.745 -15.316 -15.358 0.50 50.56  ? 572  THR A N   1 
ATOM   2137 C  CA  . THR A 1 309 ? -19.684 -16.615 -14.630 0.50 51.23  ? 572  THR A CA  1 
ATOM   2138 C  C   . THR A 1 309 ? -18.502 -17.477 -15.100 0.50 49.34  ? 572  THR A C   1 
ATOM   2139 O  O   . THR A 1 309 ? -18.352 -18.580 -14.554 0.50 50.61  ? 572  THR A O   1 
ATOM   2140 C  CB  . THR A 1 309 ? -20.977 -17.425 -14.797 0.50 52.24  ? 572  THR A CB  1 
ATOM   2141 O  OG1 . THR A 1 309 ? -21.072 -17.862 -16.153 0.50 52.51  ? 572  THR A OG1 1 
ATOM   2142 C  CG2 . THR A 1 309 ? -22.219 -16.641 -14.435 0.50 57.22  ? 572  THR A CG2 1 
ATOM   2143 N  N   . TYR A 1 310 ? -17.714 -17.022 -16.079 0.50 49.89  ? 573  TYR A N   1 
ATOM   2144 C  CA  . TYR A 1 310 ? -16.605 -17.809 -16.687 0.50 51.77  ? 573  TYR A CA  1 
ATOM   2145 C  C   . TYR A 1 310 ? -15.292 -17.013 -16.620 0.50 52.01  ? 573  TYR A C   1 
ATOM   2146 O  O   . TYR A 1 310 ? -14.231 -17.645 -16.469 0.50 51.91  ? 573  TYR A O   1 
ATOM   2147 C  CB  . TYR A 1 310 ? -16.922 -18.195 -18.140 0.50 49.59  ? 573  TYR A CB  1 
ATOM   2148 C  CG  . TYR A 1 310 ? -17.907 -19.327 -18.338 0.50 44.99  ? 573  TYR A CG  1 
ATOM   2149 C  CD1 . TYR A 1 310 ? -18.693 -19.801 -17.303 0.50 43.86  ? 573  TYR A CD1 1 
ATOM   2150 C  CD2 . TYR A 1 310 ? -18.088 -19.897 -19.585 0.50 43.63  ? 573  TYR A CD2 1 
ATOM   2151 C  CE1 . TYR A 1 310 ? -19.611 -20.822 -17.498 0.50 42.66  ? 573  TYR A CE1 1 
ATOM   2152 C  CE2 . TYR A 1 310 ? -18.996 -20.921 -19.797 0.50 42.26  ? 573  TYR A CE2 1 
ATOM   2153 C  CZ  . TYR A 1 310 ? -19.761 -21.390 -18.749 0.50 42.40  ? 573  TYR A CZ  1 
ATOM   2154 O  OH  . TYR A 1 310 ? -20.670 -22.394 -18.947 0.50 46.29  ? 573  TYR A OH  1 
ATOM   2155 N  N   . GLN A 1 311 ? -15.362 -15.681 -16.745 0.50 50.83  ? 574  GLN A N   1 
ATOM   2156 C  CA  . GLN A 1 311 ? -14.180 -14.778 -16.801 0.50 50.82  ? 574  GLN A CA  1 
ATOM   2157 C  C   . GLN A 1 311 ? -14.076 -13.951 -15.511 0.50 53.12  ? 574  GLN A C   1 
ATOM   2158 O  O   . GLN A 1 311 ? -13.192 -13.067 -15.457 0.50 54.05  ? 574  GLN A O   1 
ATOM   2159 C  CB  . GLN A 1 311 ? -14.262 -13.862 -18.020 0.50 50.63  ? 574  GLN A CB  1 
ATOM   2160 C  CG  . GLN A 1 311 ? -14.012 -14.585 -19.331 0.50 49.76  ? 574  GLN A CG  1 
ATOM   2161 C  CD  . GLN A 1 311 ? -13.846 -13.623 -20.479 0.50 50.33  ? 574  GLN A CD  1 
ATOM   2162 O  OE1 . GLN A 1 311 ? -13.290 -12.536 -20.332 0.50 49.14  ? 574  GLN A OE1 1 
ATOM   2163 N  NE2 . GLN A 1 311 ? -14.307 -14.036 -21.647 0.50 51.66  ? 574  GLN A NE2 1 
ATOM   2164 N  N   . ASN A 1 312 ? -14.921 -14.250 -14.516 0.50 53.45  ? 575  ASN A N   1 
ATOM   2165 C  CA  . ASN A 1 312 ? -14.964 -13.579 -13.187 0.50 54.48  ? 575  ASN A CA  1 
ATOM   2166 C  C   . ASN A 1 312 ? -15.824 -14.419 -12.237 0.50 54.53  ? 575  ASN A C   1 
ATOM   2167 O  O   . ASN A 1 312 ? -16.912 -13.959 -11.870 0.50 59.50  ? 575  ASN A O   1 
ATOM   2168 C  CB  . ASN A 1 312 ? -15.519 -12.152 -13.278 0.50 54.21  ? 575  ASN A CB  1 
ATOM   2169 C  CG  . ASN A 1 312 ? -14.660 -11.223 -14.109 0.50 56.52  ? 575  ASN A CG  1 
ATOM   2170 O  OD1 . ASN A 1 312 ? -13.572 -10.836 -13.690 0.50 61.90  ? 575  ASN A OD1 1 
ATOM   2171 N  ND2 . ASN A 1 312 ? -15.145 -10.842 -15.280 0.50 57.42  ? 575  ASN A ND2 1 
ATOM   2172 N  N   . LYS A 1 313 ? -15.351 -15.607 -11.856 0.50 59.30  ? 576  LYS A N   1 
ATOM   2173 C  CA  . LYS A 1 313 ? -16.117 -16.580 -11.034 0.50 60.54  ? 576  LYS A CA  1 
ATOM   2174 C  C   . LYS A 1 313 ? -16.257 -16.048 -9.607  0.50 62.35  ? 576  LYS A C   1 
ATOM   2175 O  O   . LYS A 1 313 ? -15.519 -15.113 -9.247  0.50 63.59  ? 576  LYS A O   1 
ATOM   2176 C  CB  . LYS A 1 313 ? -15.418 -17.941 -10.986 0.50 63.00  ? 576  LYS A CB  1 
ATOM   2177 C  CG  . LYS A 1 313 ? -14.822 -18.418 -12.300 0.50 64.15  ? 576  LYS A CG  1 
ATOM   2178 C  CD  . LYS A 1 313 ? -13.992 -19.675 -12.157 0.50 62.85  ? 576  LYS A CD  1 
ATOM   2179 C  CE  . LYS A 1 313 ? -13.193 -19.973 -13.407 0.50 63.42  ? 576  LYS A CE  1 
ATOM   2180 N  NZ  . LYS A 1 313 ? -12.619 -18.737 -13.989 0.50 64.95  ? 576  LYS A NZ  1 
ATOM   2181 N  N   . VAL A 1 314 ? -17.170 -16.648 -8.839  0.50 60.30  ? 577  VAL A N   1 
ATOM   2182 C  CA  . VAL A 1 314 ? -17.353 -16.434 -7.374  0.50 60.10  ? 577  VAL A CA  1 
ATOM   2183 C  C   . VAL A 1 314 ? -17.688 -17.800 -6.785  0.50 59.95  ? 577  VAL A C   1 
ATOM   2184 O  O   . VAL A 1 314 ? -18.601 -18.452 -7.327  0.50 58.71  ? 577  VAL A O   1 
ATOM   2185 C  CB  . VAL A 1 314 ? -18.463 -15.409 -7.058  0.50 61.34  ? 577  VAL A CB  1 
ATOM   2186 C  CG1 . VAL A 1 314 ? -18.956 -15.544 -5.625  0.50 59.84  ? 577  VAL A CG1 1 
ATOM   2187 C  CG2 . VAL A 1 314 ? -18.028 -13.979 -7.345  0.50 58.55  ? 577  VAL A CG2 1 
ATOM   2188 N  N   . VAL A 1 315 ? -16.977 -18.210 -5.733  0.50 62.47  ? 578  VAL A N   1 
ATOM   2189 C  CA  . VAL A 1 315 ? -17.018 -19.605 -5.208  0.50 63.73  ? 578  VAL A CA  1 
ATOM   2190 C  C   . VAL A 1 315 ? -17.116 -19.576 -3.684  0.50 64.99  ? 578  VAL A C   1 
ATOM   2191 O  O   . VAL A 1 315 ? -16.388 -18.785 -3.063  0.50 66.26  ? 578  VAL A O   1 
ATOM   2192 C  CB  . VAL A 1 315 ? -15.776 -20.397 -5.654  0.50 64.89  ? 578  VAL A CB  1 
ATOM   2193 C  CG1 . VAL A 1 315 ? -16.004 -21.893 -5.530  0.50 67.19  ? 578  VAL A CG1 1 
ATOM   2194 C  CG2 . VAL A 1 315 ? -15.348 -20.027 -7.064  0.50 65.37  ? 578  VAL A CG2 1 
ATOM   2195 N  N   . ARG A 1 316 ? -17.944 -20.466 -3.134  0.50 68.21  ? 579  ARG A N   1 
ATOM   2196 C  CA  . ARG A 1 316 ? -18.059 -20.605 -1.664  0.50 77.83  ? 579  ARG A CA  1 
ATOM   2197 C  C   . ARG A 1 316 ? -17.398 -21.931 -1.275  0.50 83.17  ? 579  ARG A C   1 
ATOM   2198 O  O   . ARG A 1 316 ? -17.940 -22.987 -1.646  0.50 81.39  ? 579  ARG A O   1 
ATOM   2199 C  CB  . ARG A 1 316 ? -19.530 -20.576 -1.243  0.50 81.05  ? 579  ARG A CB  1 
ATOM   2200 C  CG  . ARG A 1 316 ? -20.435 -21.484 -2.061  0.50 85.70  ? 579  ARG A CG  1 
ATOM   2201 C  CD  . ARG A 1 316 ? -21.836 -21.527 -1.487  0.50 89.54  ? 579  ARG A CD  1 
ATOM   2202 N  NE  . ARG A 1 316 ? -22.422 -20.200 -1.382  0.50 93.63  ? 579  ARG A NE  1 
ATOM   2203 C  CZ  . ARG A 1 316 ? -23.634 -19.952 -0.903  0.50 95.81  ? 579  ARG A CZ  1 
ATOM   2204 N  NH1 . ARG A 1 316 ? -24.081 -18.710 -0.846  0.50 96.68  ? 579  ARG A NH1 1 
ATOM   2205 N  NH2 . ARG A 1 316 ? -24.395 -20.947 -0.483  0.50 94.73  ? 579  ARG A NH2 1 
ATOM   2206 N  N   . VAL A 1 317 ? -16.265 -21.873 -0.570  0.50 84.63  ? 580  VAL A N   1 
ATOM   2207 C  CA  . VAL A 1 317 ? -15.515 -23.112 -0.208  0.50 83.24  ? 580  VAL A CA  1 
ATOM   2208 C  C   . VAL A 1 317 ? -15.613 -23.332 1.302   0.50 85.20  ? 580  VAL A C   1 
ATOM   2209 O  O   . VAL A 1 317 ? -15.440 -22.353 2.045   0.50 80.12  ? 580  VAL A O   1 
ATOM   2210 C  CB  . VAL A 1 317 ? -14.047 -23.017 -0.658  0.50 84.83  ? 580  VAL A CB  1 
ATOM   2211 C  CG1 . VAL A 1 317 ? -13.278 -24.288 -0.338  0.50 86.81  ? 580  VAL A CG1 1 
ATOM   2212 C  CG2 . VAL A 1 317 ? -13.933 -22.681 -2.136  0.50 85.16  ? 580  VAL A CG2 1 
ATOM   2213 N  N   . GLN A 1 318 ? -15.879 -24.568 1.730   0.50 91.60  ? 581  GLN A N   1 
ATOM   2214 C  CA  . GLN A 1 318 ? -15.917 -24.883 3.184   0.50 94.19  ? 581  GLN A CA  1 
ATOM   2215 C  C   . GLN A 1 318 ? -14.490 -25.054 3.711   0.50 100.78 ? 581  GLN A C   1 
ATOM   2216 O  O   . GLN A 1 318 ? -13.674 -25.674 3.006   0.50 97.67  ? 581  GLN A O   1 
ATOM   2217 C  CB  . GLN A 1 318 ? -16.719 -26.155 3.453   0.50 88.45  ? 581  GLN A CB  1 
ATOM   2218 C  CG  . GLN A 1 318 ? -18.120 -25.881 3.975   0.50 87.67  ? 581  GLN A CG  1 
ATOM   2219 C  CD  . GLN A 1 318 ? -18.770 -27.125 4.527   0.50 86.22  ? 581  GLN A CD  1 
ATOM   2220 O  OE1 . GLN A 1 318 ? -18.150 -28.180 4.625   0.50 82.19  ? 581  GLN A OE1 1 
ATOM   2221 N  NE2 . GLN A 1 318 ? -20.034 -27.005 4.898   0.50 85.40  ? 581  GLN A NE2 1 
ATOM   2222 N  N   . ARG A 1 319 ? -14.207 -24.517 4.899   0.50 105.96 ? 582  ARG A N   1 
ATOM   2223 C  CA  . ARG A 1 319 ? -12.871 -24.699 5.523   0.50 110.81 ? 582  ARG A CA  1 
ATOM   2224 C  C   . ARG A 1 319 ? -13.080 -25.138 6.973   0.50 120.38 ? 582  ARG A C   1 
ATOM   2225 O  O   . ARG A 1 319 ? -13.506 -24.299 7.787   0.50 121.62 ? 582  ARG A O   1 
ATOM   2226 C  CB  . ARG A 1 319 ? -12.061 -23.403 5.443   0.50 110.45 ? 582  ARG A CB  1 
ATOM   2227 C  CG  . ARG A 1 319 ? -10.598 -23.559 5.829   0.50 110.74 ? 582  ARG A CG  1 
ATOM   2228 C  CD  . ARG A 1 319 ? -9.708  -22.576 5.094   0.50 111.98 ? 582  ARG A CD  1 
ATOM   2229 N  NE  . ARG A 1 319 ? -10.118 -21.191 5.270   0.50 112.32 ? 582  ARG A NE  1 
ATOM   2230 C  CZ  . ARG A 1 319 ? -9.586  -20.353 6.151   0.50 113.55 ? 582  ARG A CZ  1 
ATOM   2231 N  NH1 . ARG A 1 319 ? -8.605  -20.757 6.940   0.50 113.57 ? 582  ARG A NH1 1 
ATOM   2232 N  NH2 . ARG A 1 319 ? -10.029 -19.112 6.234   0.50 114.36 ? 582  ARG A NH2 1 
ATOM   2233 N  N   . PRO A 1 320 ? -12.800 -26.410 7.327   0.50 131.39 ? 583  PRO A N   1 
ATOM   2234 C  CA  . PRO A 1 320 ? -13.038 -26.911 8.684   0.50 131.54 ? 583  PRO A CA  1 
ATOM   2235 C  C   . PRO A 1 320 ? -12.312 -26.050 9.723   0.50 128.48 ? 583  PRO A C   1 
ATOM   2236 O  O   . PRO A 1 320 ? -12.832 -25.902 10.813  0.50 127.18 ? 583  PRO A O   1 
ATOM   2237 C  CB  . PRO A 1 320 ? -12.420 -28.313 8.654   0.50 134.12 ? 583  PRO A CB  1 
ATOM   2238 C  CG  . PRO A 1 320 ? -12.506 -28.719 7.202   0.50 133.65 ? 583  PRO A CG  1 
ATOM   2239 C  CD  . PRO A 1 320 ? -12.252 -27.436 6.439   0.50 133.58 ? 583  PRO A CD  1 
ATOM   2240 N  N   . THR A 1 321 ? -11.140 -25.520 9.365   0.50 122.50 ? 584  THR A N   1 
ATOM   2241 C  CA  . THR A 1 321 ? -10.393 -24.621 10.282  0.50 120.06 ? 584  THR A CA  1 
ATOM   2242 C  C   . THR A 1 321 ? -11.380 -23.837 11.152  0.50 114.10 ? 584  THR A C   1 
ATOM   2243 O  O   . THR A 1 321 ? -11.258 -23.944 12.387  0.50 107.88 ? 584  THR A O   1 
ATOM   2244 C  CB  . THR A 1 321 ? -9.493  -23.672 9.486   0.50 120.98 ? 584  THR A CB  1 
ATOM   2245 O  OG1 . THR A 1 321 ? -10.335 -22.791 8.743   0.50 121.91 ? 584  THR A OG1 1 
ATOM   2246 C  CG2 . THR A 1 321 ? -8.555  -24.401 8.549   0.50 121.45 ? 584  THR A CG2 1 
ATOM   2247 N  N   . THR A 1 325 ? -15.637 -25.224 10.924  0.50 128.11 ? 588  THR A N   1 
ATOM   2248 C  CA  . THR A 1 325 ? -16.090 -25.259 9.507   0.50 127.39 ? 588  THR A CA  1 
ATOM   2249 C  C   . THR A 1 325 ? -16.748 -23.922 9.146   0.50 127.85 ? 588  THR A C   1 
ATOM   2250 O  O   . THR A 1 325 ? -17.872 -23.665 9.626   0.50 123.88 ? 588  THR A O   1 
ATOM   2251 C  CB  . THR A 1 325 ? -17.049 -26.430 9.258   0.50 128.96 ? 588  THR A CB  1 
ATOM   2252 O  OG1 . THR A 1 325 ? -16.272 -27.623 9.143   0.50 131.21 ? 588  THR A OG1 1 
ATOM   2253 C  CG2 . THR A 1 325 ? -17.885 -26.252 8.010   0.50 129.31 ? 588  THR A CG2 1 
ATOM   2254 N  N   . VAL A 1 326 ? -16.062 -23.111 8.332   0.50 128.44 ? 589  VAL A N   1 
ATOM   2255 C  CA  . VAL A 1 326 ? -16.580 -21.828 7.767   0.50 126.59 ? 589  VAL A CA  1 
ATOM   2256 C  C   . VAL A 1 326 ? -16.703 -21.987 6.246   0.50 122.89 ? 589  VAL A C   1 
ATOM   2257 O  O   . VAL A 1 326 ? -16.126 -22.955 5.703   0.50 120.39 ? 589  VAL A O   1 
ATOM   2258 C  CB  . VAL A 1 326 ? -15.676 -20.636 8.140   0.50 127.81 ? 589  VAL A CB  1 
ATOM   2259 C  CG1 . VAL A 1 326 ? -15.054 -20.811 9.517   0.50 129.48 ? 589  VAL A CG1 1 
ATOM   2260 C  CG2 . VAL A 1 326 ? -14.600 -20.388 7.093   0.50 127.13 ? 589  VAL A CG2 1 
ATOM   2261 N  N   . MET A 1 327 ? -17.431 -21.076 5.591   0.50 116.46 ? 590  MET A N   1 
ATOM   2262 C  CA  . MET A 1 327 ? -17.673 -21.090 4.123   0.50 111.89 ? 590  MET A CA  1 
ATOM   2263 C  C   . MET A 1 327 ? -17.019 -19.861 3.482   0.50 103.70 ? 590  MET A C   1 
ATOM   2264 O  O   . MET A 1 327 ? -17.730 -18.865 3.258   0.50 99.91  ? 590  MET A O   1 
ATOM   2265 C  CB  . MET A 1 327 ? -19.173 -21.087 3.809   0.50 112.34 ? 590  MET A CB  1 
ATOM   2266 C  CG  . MET A 1 327 ? -19.485 -21.340 2.343   0.50 114.32 ? 590  MET A CG  1 
ATOM   2267 S  SD  . MET A 1 327 ? -19.281 -23.078 1.851   0.50 114.82 ? 590  MET A SD  1 
ATOM   2268 C  CE  . MET A 1 327 ? -20.707 -23.815 2.651   0.50 111.67 ? 590  MET A CE  1 
ATOM   2269 N  N   . ASP A 1 328 ? -15.718 -19.946 3.189   0.50 99.33  ? 591  ASP A N   1 
ATOM   2270 C  CA  . ASP A 1 328 ? -14.933 -18.882 2.509   0.50 98.66  ? 591  ASP A CA  1 
ATOM   2271 C  C   . ASP A 1 328 ? -15.633 -18.485 1.204   0.50 91.64  ? 591  ASP A C   1 
ATOM   2272 O  O   . ASP A 1 328 ? -16.114 -19.381 0.486   0.50 87.00  ? 591  ASP A O   1 
ATOM   2273 C  CB  . ASP A 1 328 ? -13.498 -19.338 2.230   0.50 102.42 ? 591  ASP A CB  1 
ATOM   2274 C  CG  . ASP A 1 328 ? -12.658 -19.509 3.484   0.50 104.69 ? 591  ASP A CG  1 
ATOM   2275 O  OD1 . ASP A 1 328 ? -12.700 -18.602 4.342   0.50 104.73 ? 591  ASP A OD1 1 
ATOM   2276 O  OD2 . ASP A 1 328 ? -11.978 -20.551 3.597   0.50 101.00 ? 591  ASP A OD2 1 
ATOM   2277 N  N   . ILE A 1 329 ? -15.683 -17.183 0.923   0.50 83.89  ? 592  ILE A N   1 
ATOM   2278 C  CA  . ILE A 1 329 ? -16.158 -16.618 -0.371  0.50 77.65  ? 592  ILE A CA  1 
ATOM   2279 C  C   . ILE A 1 329 ? -14.931 -16.082 -1.108  0.50 76.31  ? 592  ILE A C   1 
ATOM   2280 O  O   . ILE A 1 329 ? -14.426 -15.010 -0.729  0.50 74.72  ? 592  ILE A O   1 
ATOM   2281 C  CB  . ILE A 1 329 ? -17.234 -15.535 -0.152  0.50 76.80  ? 592  ILE A CB  1 
ATOM   2282 C  CG1 . ILE A 1 329 ? -18.534 -16.139 0.385   0.50 75.67  ? 592  ILE A CG1 1 
ATOM   2283 C  CG2 . ILE A 1 329 ? -17.469 -14.736 -1.424  0.50 75.13  ? 592  ILE A CG2 1 
ATOM   2284 C  CD1 . ILE A 1 329 ? -18.976 -17.387 -0.339  0.50 74.99  ? 592  ILE A CD1 1 
ATOM   2285 N  N   . ILE A 1 330 ? -14.462 -16.829 -2.108  0.50 79.22  ? 593  ILE A N   1 
ATOM   2286 C  CA  . ILE A 1 330 ? -13.251 -16.494 -2.911  0.50 77.87  ? 593  ILE A CA  1 
ATOM   2287 C  C   . ILE A 1 330 ? -13.673 -16.257 -4.362  0.50 71.33  ? 593  ILE A C   1 
ATOM   2288 O  O   . ILE A 1 330 ? -14.784 -16.679 -4.731  0.50 68.35  ? 593  ILE A O   1 
ATOM   2289 C  CB  . ILE A 1 330 ? -12.206 -17.618 -2.797  0.50 80.30  ? 593  ILE A CB  1 
ATOM   2290 C  CG1 . ILE A 1 330 ? -12.844 -18.992 -3.019  0.50 79.79  ? 593  ILE A CG1 1 
ATOM   2291 C  CG2 . ILE A 1 330 ? -11.484 -17.532 -1.463  0.50 82.25  ? 593  ILE A CG2 1 
ATOM   2292 C  CD1 . ILE A 1 330 ? -11.852 -20.090 -3.332  0.50 79.57  ? 593  ILE A CD1 1 
ATOM   2293 N  N   . SER A 1 331 ? -12.802 -15.617 -5.143  0.50 67.71  ? 594  SER A N   1 
ATOM   2294 C  CA  . SER A 1 331 ? -13.019 -15.295 -6.575  0.50 68.01  ? 594  SER A CA  1 
ATOM   2295 C  C   . SER A 1 331 ? -11.715 -15.498 -7.353  0.50 68.90  ? 594  SER A C   1 
ATOM   2296 O  O   . SER A 1 331 ? -10.673 -15.716 -6.708  0.50 70.31  ? 594  SER A O   1 
ATOM   2297 C  CB  . SER A 1 331 ? -13.532 -13.891 -6.729  0.50 66.10  ? 594  SER A CB  1 
ATOM   2298 O  OG  . SER A 1 331 ? -12.487 -12.954 -6.520  0.50 64.57  ? 594  SER A OG  1 
ATOM   2299 N  N   . ARG A 1 332 ? -11.795 -15.427 -8.685  0.50 67.70  ? 595  ARG A N   1 
ATOM   2300 C  CA  . ARG A 1 332 ? -10.654 -15.511 -9.634  0.50 66.70  ? 595  ARG A CA  1 
ATOM   2301 C  C   . ARG A 1 332 ? -11.208 -15.436 -11.059 0.50 66.69  ? 595  ARG A C   1 
ATOM   2302 O  O   . ARG A 1 332 ? -12.399 -15.773 -11.246 0.50 68.67  ? 595  ARG A O   1 
ATOM   2303 C  CB  . ARG A 1 332 ? -9.871  -16.814 -9.455  0.50 69.30  ? 595  ARG A CB  1 
ATOM   2304 C  CG  . ARG A 1 332 ? -10.354 -17.947 -10.347 0.50 68.63  ? 595  ARG A CG  1 
ATOM   2305 C  CD  . ARG A 1 332 ? -9.449  -19.163 -10.280 0.50 70.73  ? 595  ARG A CD  1 
ATOM   2306 N  NE  . ARG A 1 332 ? -8.087  -18.883 -10.709 0.50 65.97  ? 595  ARG A NE  1 
ATOM   2307 C  CZ  . ARG A 1 332 ? -7.002  -19.123 -9.982  0.50 65.10  ? 595  ARG A CZ  1 
ATOM   2308 N  NH1 . ARG A 1 332 ? -7.118  -19.658 -8.778  0.50 67.08  ? 595  ARG A NH1 1 
ATOM   2309 N  NH2 . ARG A 1 332 ? -5.807  -18.841 -10.467 0.50 62.89  ? 595  ARG A NH2 1 
ATOM   2310 N  N   . ARG A 1 333 ? -10.367 -15.032 -12.013 1.00 63.40  ? 596  ARG A N   1 
ATOM   2311 C  CA  . ARG A 1 333 ? -10.779 -14.750 -13.407 1.00 65.66  ? 596  ARG A CA  1 
ATOM   2312 C  C   . ARG A 1 333 ? -10.537 -15.962 -14.319 1.00 71.80  ? 596  ARG A C   1 
ATOM   2313 O  O   . ARG A 1 333 ? -11.301 -16.117 -15.304 1.00 70.75  ? 596  ARG A O   1 
ATOM   2314 C  CB  . ARG A 1 333 ? -10.016 -13.497 -13.828 1.00 63.89  ? 596  ARG A CB  1 
ATOM   2315 C  CG  . ARG A 1 333 ? -10.327 -12.318 -12.908 1.00 70.44  ? 596  ARG A CG  1 
ATOM   2316 C  CD  . ARG A 1 333 ? -10.253 -10.990 -13.631 1.00 81.71  ? 596  ARG A CD  1 
ATOM   2317 N  NE  . ARG A 1 333 ? -11.005 -11.040 -14.889 1.00 90.59  ? 596  ARG A NE  1 
ATOM   2318 C  CZ  . ARG A 1 333 ? -10.686 -10.380 -16.006 1.00 95.70  ? 596  ARG A CZ  1 
ATOM   2319 N  NH1 . ARG A 1 333 ? -9.623  -9.585  -16.048 1.00 92.25  ? 596  ARG A NH1 1 
ATOM   2320 N  NH2 . ARG A 1 333 ? -11.435 -10.534 -17.087 1.00 94.09  ? 596  ARG A NH2 1 
ATOM   2321 N  N   . ASP A 1 334 ? -9.549  -16.802 -13.995 1.00 65.53  ? 597  ASP A N   1 
ATOM   2322 C  CA  . ASP A 1 334 ? -8.995  -17.825 -14.919 1.00 59.67  ? 597  ASP A CA  1 
ATOM   2323 C  C   . ASP A 1 334 ? -9.341  -19.232 -14.404 1.00 56.16  ? 597  ASP A C   1 
ATOM   2324 O  O   . ASP A 1 334 ? -10.120 -19.329 -13.441 1.00 50.52  ? 597  ASP A O   1 
ATOM   2325 C  CB  . ASP A 1 334 ? -7.507  -17.558 -15.162 1.00 65.13  ? 597  ASP A CB  1 
ATOM   2326 C  CG  . ASP A 1 334 ? -6.569  -17.953 -14.032 1.00 68.46  ? 597  ASP A CG  1 
ATOM   2327 O  OD1 . ASP A 1 334 ? -7.042  -18.166 -12.910 1.00 64.90  ? 597  ASP A OD1 1 
ATOM   2328 O  OD2 . ASP A 1 334 ? -5.353  -18.075 -14.302 1.00 80.80  ? 597  ASP A OD2 1 
ATOM   2329 N  N   . GLN A 1 335 ? -8.817  -20.279 -15.068 1.00 53.39  ? 598  GLN A N   1 
ATOM   2330 C  CA  . GLN A 1 335 ? -9.155  -21.711 -14.859 1.00 48.67  ? 598  GLN A CA  1 
ATOM   2331 C  C   . GLN A 1 335 ? -10.564 -22.016 -15.378 1.00 51.66  ? 598  GLN A C   1 
ATOM   2332 O  O   . GLN A 1 335 ? -11.326 -21.082 -15.725 1.00 56.45  ? 598  GLN A O   1 
ATOM   2333 C  CB  . GLN A 1 335 ? -9.049  -22.118 -13.385 1.00 48.57  ? 598  GLN A CB  1 
ATOM   2334 C  CG  . GLN A 1 335 ? -7.702  -21.766 -12.774 1.00 55.20  ? 598  GLN A CG  1 
ATOM   2335 C  CD  . GLN A 1 335 ? -7.396  -22.523 -11.507 1.00 55.73  ? 598  GLN A CD  1 
ATOM   2336 O  OE1 . GLN A 1 335 ? -8.250  -23.149 -10.893 1.00 67.48  ? 598  GLN A OE1 1 
ATOM   2337 N  NE2 . GLN A 1 335 ? -6.142  -22.489 -11.123 1.00 57.94  ? 598  GLN A NE2 1 
ATOM   2338 N  N   . ARG A 1 336 ? -10.896 -23.307 -15.441 0.50 52.87  ? 599  ARG A N   1 
ATOM   2339 C  CA  . ARG A 1 336 ? -12.190 -23.818 -15.961 0.50 55.21  ? 599  ARG A CA  1 
ATOM   2340 C  C   . ARG A 1 336 ? -13.207 -23.888 -14.820 0.50 59.87  ? 599  ARG A C   1 
ATOM   2341 O  O   . ARG A 1 336 ? -13.003 -24.696 -13.881 0.50 61.07  ? 599  ARG A O   1 
ATOM   2342 C  CB  . ARG A 1 336 ? -12.015 -25.194 -16.607 0.50 52.40  ? 599  ARG A CB  1 
ATOM   2343 C  CG  . ARG A 1 336 ? -13.308 -25.767 -17.163 0.50 50.20  ? 599  ARG A CG  1 
ATOM   2344 C  CD  . ARG A 1 336 ? -13.798 -24.960 -18.345 0.50 48.05  ? 599  ARG A CD  1 
ATOM   2345 N  NE  . ARG A 1 336 ? -12.980 -25.215 -19.514 0.50 44.70  ? 599  ARG A NE  1 
ATOM   2346 C  CZ  . ARG A 1 336 ? -12.812 -24.360 -20.508 0.50 43.48  ? 599  ARG A CZ  1 
ATOM   2347 N  NH1 . ARG A 1 336 ? -13.418 -23.186 -20.476 0.50 43.53  ? 599  ARG A NH1 1 
ATOM   2348 N  NH2 . ARG A 1 336 ? -12.049 -24.690 -21.534 0.50 42.84  ? 599  ARG A NH2 1 
ATOM   2349 N  N   . GLY A 1 337 ? -14.254 -23.064 -14.920 0.50 63.92  ? 600  GLY A N   1 
ATOM   2350 C  CA  . GLY A 1 337 ? -15.388 -23.000 -13.979 0.50 65.73  ? 600  GLY A CA  1 
ATOM   2351 C  C   . GLY A 1 337 ? -16.698 -22.873 -14.732 0.50 68.50  ? 600  GLY A C   1 
ATOM   2352 O  O   . GLY A 1 337 ? -17.170 -21.731 -14.914 0.50 70.34  ? 600  GLY A O   1 
ATOM   2353 N  N   . SER A 1 338 ? -17.240 -24.015 -15.167 0.50 68.01  ? 601  SER A N   1 
ATOM   2354 C  CA  . SER A 1 338 ? -18.480 -24.155 -15.970 0.50 65.19  ? 601  SER A CA  1 
ATOM   2355 C  C   . SER A 1 338 ? -19.127 -25.504 -15.647 0.50 64.10  ? 601  SER A C   1 
ATOM   2356 O  O   . SER A 1 338 ? -18.531 -26.274 -14.878 0.50 62.10  ? 601  SER A O   1 
ATOM   2357 C  CB  . SER A 1 338 ? -18.185 -24.037 -17.444 0.50 66.81  ? 601  SER A CB  1 
ATOM   2358 O  OG  . SER A 1 338 ? -17.170 -23.071 -17.682 0.50 69.19  ? 601  SER A OG  1 
ATOM   2359 N  N   . GLY A 1 339 ? -20.292 -25.777 -16.235 1.00 64.89  ? 602  GLY A N   1 
ATOM   2360 C  CA  . GLY A 1 339 ? -20.973 -27.074 -16.094 1.00 68.03  ? 602  GLY A CA  1 
ATOM   2361 C  C   . GLY A 1 339 ? -20.120 -28.147 -16.739 1.00 66.25  ? 602  GLY A C   1 
ATOM   2362 O  O   . GLY A 1 339 ? -19.352 -27.827 -17.667 1.00 58.08  ? 602  GLY A O   1 
ATOM   2363 N  N   . GLN A 1 340 ? -20.256 -29.391 -16.277 0.50 66.56  ? 603  GLN A N   1 
ATOM   2364 C  CA  . GLN A 1 340 ? -19.419 -30.533 -16.727 0.50 66.89  ? 603  GLN A CA  1 
ATOM   2365 C  C   . GLN A 1 340 ? -19.592 -30.737 -18.239 0.50 62.47  ? 603  GLN A C   1 
ATOM   2366 O  O   . GLN A 1 340 ? -18.609 -31.138 -18.878 0.50 63.63  ? 603  GLN A O   1 
ATOM   2367 C  CB  . GLN A 1 340 ? -19.763 -31.788 -15.923 0.50 70.02  ? 603  GLN A CB  1 
ATOM   2368 C  CG  . GLN A 1 340 ? -21.047 -32.474 -16.363 0.50 71.87  ? 603  GLN A CG  1 
ATOM   2369 C  CD  . GLN A 1 340 ? -21.347 -33.685 -15.513 0.50 73.94  ? 603  GLN A CD  1 
ATOM   2370 O  OE1 . GLN A 1 340 ? -21.154 -33.674 -14.299 0.50 74.68  ? 603  GLN A OE1 1 
ATOM   2371 N  NE2 . GLN A 1 340 ? -21.821 -34.745 -16.149 0.50 76.90  ? 603  GLN A NE2 1 
ATOM   2372 N  N   . VAL A 1 341 ? -20.779 -30.462 -18.791 1.00 59.79  ? 604  VAL A N   1 
ATOM   2373 C  CA  . VAL A 1 341 ? -21.062 -30.691 -20.241 1.00 55.64  ? 604  VAL A CA  1 
ATOM   2374 C  C   . VAL A 1 341 ? -20.530 -29.523 -21.072 1.00 53.05  ? 604  VAL A C   1 
ATOM   2375 O  O   . VAL A 1 341 ? -19.971 -29.795 -22.160 1.00 42.92  ? 604  VAL A O   1 
ATOM   2376 C  CB  . VAL A 1 341 ? -22.550 -30.950 -20.531 1.00 54.97  ? 604  VAL A CB  1 
ATOM   2377 C  CG1 . VAL A 1 341 ? -22.769 -31.008 -22.030 1.00 60.68  ? 604  VAL A CG1 1 
ATOM   2378 C  CG2 . VAL A 1 341 ? -23.074 -32.215 -19.859 1.00 51.67  ? 604  VAL A CG2 1 
ATOM   2379 N  N   . VAL A 1 342 ? -20.693 -28.267 -20.639 1.00 47.95  ? 605  VAL A N   1 
ATOM   2380 C  CA  . VAL A 1 342 ? -20.069 -27.152 -21.416 1.00 44.74  ? 605  VAL A CA  1 
ATOM   2381 C  C   . VAL A 1 342 ? -18.544 -27.237 -21.266 1.00 39.74  ? 605  VAL A C   1 
ATOM   2382 O  O   . VAL A 1 342 ? -17.839 -26.925 -22.234 1.00 39.93  ? 605  VAL A O   1 
ATOM   2383 C  CB  . VAL A 1 342 ? -20.659 -25.788 -21.031 1.00 44.43  ? 605  VAL A CB  1 
ATOM   2384 C  CG1 . VAL A 1 342 ? -19.851 -24.624 -21.572 1.00 45.64  ? 605  VAL A CG1 1 
ATOM   2385 C  CG2 . VAL A 1 342 ? -22.099 -25.695 -21.511 1.00 45.65  ? 605  VAL A CG2 1 
ATOM   2386 N  N   . THR A 1 343 ? -18.041 -27.646 -20.104 1.00 34.35  ? 606  THR A N   1 
ATOM   2387 C  CA  . THR A 1 343 ? -16.580 -27.909 -19.884 1.00 38.55  ? 606  THR A CA  1 
ATOM   2388 C  C   . THR A 1 343 ? -16.023 -28.889 -20.940 1.00 32.08  ? 606  THR A C   1 
ATOM   2389 O  O   . THR A 1 343 ? -15.005 -28.598 -21.513 1.00 36.14  ? 606  THR A O   1 
ATOM   2390 C  CB  . THR A 1 343 ? -16.356 -28.425 -18.460 1.00 38.07  ? 606  THR A CB  1 
ATOM   2391 O  OG1 . THR A 1 343 ? -16.723 -27.292 -17.684 1.00 41.00  ? 606  THR A OG1 1 
ATOM   2392 C  CG2 . THR A 1 343 ? -14.927 -28.848 -18.183 1.00 37.94  ? 606  THR A CG2 1 
ATOM   2393 N  N   . TYR A 1 344 ? -16.754 -29.972 -21.247 1.00 37.56  ? 607  TYR A N   1 
ATOM   2394 C  CA  . TYR A 1 344 ? -16.359 -30.988 -22.243 1.00 32.45  ? 607  TYR A CA  1 
ATOM   2395 C  C   . TYR A 1 344 ? -16.116 -30.283 -23.585 1.00 33.18  ? 607  TYR A C   1 
ATOM   2396 O  O   . TYR A 1 344 ? -15.054 -30.488 -24.200 1.00 34.08  ? 607  TYR A O   1 
ATOM   2397 C  CB  . TYR A 1 344 ? -17.389 -32.124 -22.351 1.00 33.54  ? 607  TYR A CB  1 
ATOM   2398 C  CG  . TYR A 1 344 ? -16.989 -33.168 -23.375 1.00 30.08  ? 607  TYR A CG  1 
ATOM   2399 C  CD1 . TYR A 1 344 ? -16.066 -34.146 -23.079 1.00 34.53  ? 607  TYR A CD1 1 
ATOM   2400 C  CD2 . TYR A 1 344 ? -17.438 -33.098 -24.678 1.00 33.09  ? 607  TYR A CD2 1 
ATOM   2401 C  CE1 . TYR A 1 344 ? -15.653 -35.065 -24.028 1.00 34.14  ? 607  TYR A CE1 1 
ATOM   2402 C  CE2 . TYR A 1 344 ? -17.051 -34.011 -25.640 1.00 36.86  ? 607  TYR A CE2 1 
ATOM   2403 C  CZ  . TYR A 1 344 ? -16.157 -35.013 -25.312 1.00 35.40  ? 607  TYR A CZ  1 
ATOM   2404 O  OH  . TYR A 1 344 ? -15.709 -35.871 -26.279 1.00 36.44  ? 607  TYR A OH  1 
ATOM   2405 N  N   . GLY A 1 345 ? -17.101 -29.506 -24.052 1.00 32.65  ? 608  GLY A N   1 
ATOM   2406 C  CA  . GLY A 1 345 ? -17.075 -28.911 -25.399 1.00 31.80  ? 608  GLY A CA  1 
ATOM   2407 C  C   . GLY A 1 345 ? -15.990 -27.851 -25.515 1.00 29.46  ? 608  GLY A C   1 
ATOM   2408 O  O   . GLY A 1 345 ? -15.348 -27.817 -26.519 1.00 35.42  ? 608  GLY A O   1 
ATOM   2409 N  N   . LEU A 1 346 ? -15.809 -27.012 -24.501 1.00 29.03  ? 609  LEU A N   1 
ATOM   2410 C  CA  . LEU A 1 346 ? -14.813 -25.922 -24.516 1.00 35.42  ? 609  LEU A CA  1 
ATOM   2411 C  C   . LEU A 1 346 ? -13.387 -26.494 -24.312 1.00 34.12  ? 609  LEU A C   1 
ATOM   2412 O  O   . LEU A 1 346 ? -12.448 -26.005 -24.983 1.00 32.71  ? 609  LEU A O   1 
ATOM   2413 C  CB  . LEU A 1 346 ? -15.208 -24.897 -23.445 1.00 32.57  ? 609  LEU A CB  1 
ATOM   2414 C  CG  . LEU A 1 346 ? -16.533 -24.174 -23.701 1.00 36.67  ? 609  LEU A CG  1 
ATOM   2415 C  CD1 . LEU A 1 346 ? -16.800 -23.151 -22.612 1.00 39.53  ? 609  LEU A CD1 1 
ATOM   2416 C  CD2 . LEU A 1 346 ? -16.546 -23.481 -25.047 1.00 34.31  ? 609  LEU A CD2 1 
ATOM   2417 N  N   . ASN A 1 347 ? -13.248 -27.536 -23.485 1.00 33.28  ? 610  ASN A N   1 
ATOM   2418 C  CA  . ASN A 1 347 ? -12.033 -28.394 -23.423 1.00 31.27  ? 610  ASN A CA  1 
ATOM   2419 C  C   . ASN A 1 347 ? -11.724 -28.976 -24.807 1.00 29.71  ? 610  ASN A C   1 
ATOM   2420 O  O   . ASN A 1 347 ? -10.653 -28.693 -25.313 1.00 30.68  ? 610  ASN A O   1 
ATOM   2421 C  CB  . ASN A 1 347 ? -12.143 -29.461 -22.352 1.00 27.09  ? 610  ASN A CB  1 
ATOM   2422 C  CG  . ASN A 1 347 ? -11.952 -28.856 -20.983 1.00 32.56  ? 610  ASN A CG  1 
ATOM   2423 O  OD1 . ASN A 1 347 ? -11.507 -27.717 -20.834 1.00 30.37  ? 610  ASN A OD1 1 
ATOM   2424 N  ND2 . ASN A 1 347 ? -12.235 -29.640 -19.962 1.00 41.39  ? 610  ASN A ND2 1 
ATOM   2425 N  N   . THR A 1 348 ? -12.683 -29.623 -25.472 1.00 31.35  ? 611  THR A N   1 
ATOM   2426 C  CA  . THR A 1 348 ? -12.417 -30.162 -26.817 1.00 29.93  ? 611  THR A CA  1 
ATOM   2427 C  C   . THR A 1 348 ? -11.901 -29.025 -27.714 1.00 33.22  ? 611  THR A C   1 
ATOM   2428 O  O   . THR A 1 348 ? -10.915 -29.245 -28.447 1.00 30.71  ? 611  THR A O   1 
ATOM   2429 C  CB  . THR A 1 348 ? -13.639 -30.874 -27.367 1.00 28.36  ? 611  THR A CB  1 
ATOM   2430 O  OG1 . THR A 1 348 ? -14.026 -31.818 -26.376 1.00 30.32  ? 611  THR A OG1 1 
ATOM   2431 C  CG2 . THR A 1 348 ? -13.372 -31.514 -28.700 1.00 27.02  ? 611  THR A CG2 1 
ATOM   2432 N  N   . PHE A 1 349 ? -12.572 -27.875 -27.694 1.00 35.49  ? 612  PHE A N   1 
ATOM   2433 C  CA  . PHE A 1 349 ? -12.298 -26.747 -28.622 1.00 37.70  ? 612  PHE A CA  1 
ATOM   2434 C  C   . PHE A 1 349 ? -10.853 -26.244 -28.420 1.00 34.88  ? 612  PHE A C   1 
ATOM   2435 O  O   . PHE A 1 349 ? -10.094 -26.125 -29.369 1.00 29.78  ? 612  PHE A O   1 
ATOM   2436 C  CB  . PHE A 1 349 ? -13.299 -25.623 -28.368 1.00 35.52  ? 612  PHE A CB  1 
ATOM   2437 C  CG  . PHE A 1 349 ? -13.002 -24.427 -29.226 1.00 33.59  ? 612  PHE A CG  1 
ATOM   2438 C  CD1 . PHE A 1 349 ? -13.499 -24.354 -30.514 1.00 36.69  ? 612  PHE A CD1 1 
ATOM   2439 C  CD2 . PHE A 1 349 ? -12.211 -23.402 -28.758 1.00 31.49  ? 612  PHE A CD2 1 
ATOM   2440 C  CE1 . PHE A 1 349 ? -13.210 -23.265 -31.321 1.00 34.20  ? 612  PHE A CE1 1 
ATOM   2441 C  CE2 . PHE A 1 349 ? -11.946 -22.301 -29.559 1.00 33.60  ? 612  PHE A CE2 1 
ATOM   2442 C  CZ  . PHE A 1 349 ? -12.403 -22.251 -30.844 1.00 33.21  ? 612  PHE A CZ  1 
ATOM   2443 N  N   . THR A 1 350 ? -10.513 -25.926 -27.182 1.00 32.98  ? 613  THR A N   1 
ATOM   2444 C  CA  . THR A 1 350 ? -9.213  -25.323 -26.811 1.00 38.44  ? 613  THR A CA  1 
ATOM   2445 C  C   . THR A 1 350 ? -8.105  -26.365 -27.044 1.00 37.57  ? 613  THR A C   1 
ATOM   2446 O  O   . THR A 1 350 ? -7.076  -25.987 -27.569 1.00 40.00  ? 613  THR A O   1 
ATOM   2447 C  CB  . THR A 1 350 ? -9.269  -24.778 -25.383 1.00 36.45  ? 613  THR A CB  1 
ATOM   2448 O  OG1 . THR A 1 350 ? -10.330 -23.823 -25.406 1.00 36.65  ? 613  THR A OG1 1 
ATOM   2449 C  CG2 . THR A 1 350 ? -7.964  -24.141 -24.941 1.00 41.70  ? 613  THR A CG2 1 
ATOM   2450 N  N   . ASN A 1 351 ? -8.379  -27.646 -26.800 1.00 35.41  ? 614  ASN A N   1 
ATOM   2451 C  CA  . ASN A 1 351 ? -7.447  -28.758 -27.086 1.00 35.12  ? 614  ASN A CA  1 
ATOM   2452 C  C   . ASN A 1 351 ? -7.235  -28.865 -28.592 1.00 34.61  ? 614  ASN A C   1 
ATOM   2453 O  O   . ASN A 1 351 ? -6.091  -29.002 -28.985 1.00 29.92  ? 614  ASN A O   1 
ATOM   2454 C  CB  . ASN A 1 351 ? -7.914  -30.094 -26.503 1.00 32.30  ? 614  ASN A CB  1 
ATOM   2455 C  CG  . ASN A 1 351 ? -6.771  -31.039 -26.182 1.00 33.42  ? 614  ASN A CG  1 
ATOM   2456 O  OD1 . ASN A 1 351 ? -5.596  -30.708 -26.396 1.00 33.07  ? 614  ASN A OD1 1 
ATOM   2457 N  ND2 . ASN A 1 351 ? -7.093  -32.191 -25.617 1.00 31.16  ? 614  ASN A ND2 1 
ATOM   2458 N  N   . MET A 1 352 ? -8.296  -28.824 -29.392 1.00 32.48  ? 615  MET A N   1 
ATOM   2459 C  CA  . MET A 1 352 ? -8.164  -28.839 -30.877 1.00 34.72  ? 615  MET A CA  1 
ATOM   2460 C  C   . MET A 1 352 ? -7.195  -27.704 -31.288 1.00 36.96  ? 615  MET A C   1 
ATOM   2461 O  O   . MET A 1 352 ? -6.236  -27.974 -32.060 1.00 32.51  ? 615  MET A O   1 
ATOM   2462 C  CB  . MET A 1 352 ? -9.511  -28.683 -31.594 1.00 32.81  ? 615  MET A CB  1 
ATOM   2463 C  CG  . MET A 1 352 ? -10.336 -29.942 -31.591 1.00 33.65  ? 615  MET A CG  1 
ATOM   2464 S  SD  . MET A 1 352 ? -12.077 -29.703 -32.193 1.00 36.18  ? 615  MET A SD  1 
ATOM   2465 C  CE  . MET A 1 352 ? -11.761 -29.394 -33.915 1.00 33.31  ? 615  MET A CE  1 
ATOM   2466 N  N   . GLU A 1 353 ? -7.380  -26.518 -30.726 1.00 33.54  ? 616  GLU A N   1 
ATOM   2467 C  CA  . GLU A 1 353 ? -6.621  -25.292 -31.080 1.00 37.17  ? 616  GLU A CA  1 
ATOM   2468 C  C   . GLU A 1 353 ? -5.135  -25.498 -30.706 1.00 34.62  ? 616  GLU A C   1 
ATOM   2469 O  O   . GLU A 1 353 ? -4.236  -25.291 -31.545 1.00 35.37  ? 616  GLU A O   1 
ATOM   2470 C  CB  . GLU A 1 353 ? -7.280  -24.130 -30.346 1.00 35.76  ? 616  GLU A CB  1 
ATOM   2471 C  CG  . GLU A 1 353 ? -6.628  -22.767 -30.517 1.00 41.34  ? 616  GLU A CG  1 
ATOM   2472 C  CD  . GLU A 1 353 ? -6.955  -21.805 -29.368 1.00 45.33  ? 616  GLU A CD  1 
ATOM   2473 O  OE1 . GLU A 1 353 ? -8.180  -21.420 -29.193 1.00 45.99  ? 616  GLU A OE1 1 
ATOM   2474 O  OE2 . GLU A 1 353 ? -6.015  -21.515 -28.586 1.00 41.68  ? 616  GLU A OE2 1 
ATOM   2475 N  N   . ALA A 1 354 ? -4.876  -25.905 -29.478 1.00 31.85  ? 617  ALA A N   1 
ATOM   2476 C  CA  . ALA A 1 354 ? -3.511  -26.175 -28.990 1.00 34.06  ? 617  ALA A CA  1 
ATOM   2477 C  C   . ALA A 1 354 ? -2.821  -27.218 -29.888 1.00 36.79  ? 617  ALA A C   1 
ATOM   2478 O  O   . ALA A 1 354 ? -1.646  -27.013 -30.238 1.00 34.69  ? 617  ALA A O   1 
ATOM   2479 C  CB  . ALA A 1 354 ? -3.598  -26.619 -27.557 1.00 35.70  ? 617  ALA A CB  1 
ATOM   2480 N  N   . GLN A 1 355 ? -3.503  -28.318 -30.236 1.00 32.85  ? 618  GLN A N   1 
ATOM   2481 C  CA  . GLN A 1 355 ? -2.854  -29.391 -31.018 1.00 32.84  ? 618  GLN A CA  1 
ATOM   2482 C  C   . GLN A 1 355 ? -2.602  -28.924 -32.461 1.00 33.46  ? 618  GLN A C   1 
ATOM   2483 O  O   . GLN A 1 355 ? -1.601  -29.365 -33.031 1.00 34.17  ? 618  GLN A O   1 
ATOM   2484 C  CB  . GLN A 1 355 ? -3.593  -30.721 -30.937 1.00 28.78  ? 618  GLN A CB  1 
ATOM   2485 C  CG  . GLN A 1 355 ? -3.841  -31.209 -29.528 1.00 29.66  ? 618  GLN A CG  1 
ATOM   2486 C  CD  . GLN A 1 355 ? -2.540  -31.408 -28.805 1.00 33.08  ? 618  GLN A CD  1 
ATOM   2487 O  OE1 . GLN A 1 355 ? -1.555  -31.870 -29.364 1.00 34.72  ? 618  GLN A OE1 1 
ATOM   2488 N  NE2 . GLN A 1 355 ? -2.557  -31.131 -27.526 1.00 34.89  ? 618  GLN A NE2 1 
ATOM   2489 N  N   . LEU A 1 356 ? -3.460  -28.119 -33.076 1.00 32.56  ? 619  LEU A N   1 
ATOM   2490 C  CA  . LEU A 1 356 ? -3.183  -27.587 -34.451 1.00 32.99  ? 619  LEU A CA  1 
ATOM   2491 C  C   . LEU A 1 356 ? -1.932  -26.684 -34.404 1.00 33.68  ? 619  LEU A C   1 
ATOM   2492 O  O   . LEU A 1 356 ? -1.133  -26.720 -35.323 1.00 35.16  ? 619  LEU A O   1 
ATOM   2493 C  CB  . LEU A 1 356 ? -4.345  -26.727 -34.957 1.00 35.60  ? 619  LEU A CB  1 
ATOM   2494 C  CG  . LEU A 1 356 ? -5.486  -27.408 -35.689 1.00 40.48  ? 619  LEU A CG  1 
ATOM   2495 C  CD1 . LEU A 1 356 ? -6.558  -26.369 -35.957 1.00 43.30  ? 619  LEU A CD1 1 
ATOM   2496 C  CD2 . LEU A 1 356 ? -5.056  -28.046 -36.991 1.00 41.90  ? 619  LEU A CD2 1 
ATOM   2497 N  N   . ILE A 1 357 ? -1.789  -25.889 -33.362 1.00 30.63  ? 620  ILE A N   1 
ATOM   2498 C  CA  . ILE A 1 357 ? -0.639  -24.976 -33.183 1.00 34.17  ? 620  ILE A CA  1 
ATOM   2499 C  C   . ILE A 1 357 ? 0.626   -25.805 -32.954 1.00 42.92  ? 620  ILE A C   1 
ATOM   2500 O  O   . ILE A 1 357 ? 1.626   -25.496 -33.604 1.00 38.60  ? 620  ILE A O   1 
ATOM   2501 C  CB  . ILE A 1 357 ? -0.919  -23.988 -32.059 1.00 37.52  ? 620  ILE A CB  1 
ATOM   2502 C  CG1 . ILE A 1 357 ? -2.051  -23.033 -32.486 1.00 41.23  ? 620  ILE A CG1 1 
ATOM   2503 C  CG2 . ILE A 1 357 ? 0.357   -23.248 -31.671 1.00 42.44  ? 620  ILE A CG2 1 
ATOM   2504 C  CD1 . ILE A 1 357 ? -2.669  -22.222 -31.358 1.00 39.09  ? 620  ILE A CD1 1 
ATOM   2505 N  N   . ARG A 1 358 ? 0.584   -26.850 -32.126 1.00 39.60  ? 621  ARG A N   1 
ATOM   2506 C  CA  . ARG A 1 358 ? 1.772   -27.722 -31.966 1.00 32.40  ? 621  ARG A CA  1 
ATOM   2507 C  C   . ARG A 1 358 ? 2.104   -28.355 -33.317 1.00 34.95  ? 621  ARG A C   1 
ATOM   2508 O  O   . ARG A 1 358 ? 3.307   -28.510 -33.641 1.00 35.14  ? 621  ARG A O   1 
ATOM   2509 C  CB  . ARG A 1 358 ? 1.552   -28.788 -30.899 1.00 32.27  ? 621  ARG A CB  1 
ATOM   2510 C  CG  . ARG A 1 358 ? 2.788   -29.629 -30.639 1.00 31.17  ? 621  ARG A CG  1 
ATOM   2511 C  CD  . ARG A 1 358 ? 2.664   -30.557 -29.451 1.00 31.92  ? 621  ARG A CD  1 
ATOM   2512 N  NE  . ARG A 1 358 ? 3.825   -31.435 -29.361 1.00 34.06  ? 621  ARG A NE  1 
ATOM   2513 C  CZ  . ARG A 1 358 ? 4.007   -32.431 -28.498 1.00 33.32  ? 621  ARG A CZ  1 
ATOM   2514 N  NH1 . ARG A 1 358 ? 3.061   -32.799 -27.660 1.00 32.41  ? 621  ARG A NH1 1 
ATOM   2515 N  NH2 . ARG A 1 358 ? 5.147   -33.105 -28.517 1.00 39.92  ? 621  ARG A NH2 1 
ATOM   2516 N  N   . GLN A 1 359 ? 1.104   -28.773 -34.090 1.00 32.57  ? 622  GLN A N   1 
ATOM   2517 C  CA  . GLN A 1 359 ? 1.348   -29.288 -35.459 1.00 34.70  ? 622  GLN A CA  1 
ATOM   2518 C  C   . GLN A 1 359 ? 1.990   -28.155 -36.314 1.00 40.66  ? 622  GLN A C   1 
ATOM   2519 O  O   . GLN A 1 359 ? 2.857   -28.456 -37.167 1.00 45.32  ? 622  GLN A O   1 
ATOM   2520 C  CB  . GLN A 1 359 ? 0.083   -29.828 -36.140 1.00 33.70  ? 622  GLN A CB  1 
ATOM   2521 C  CG  . GLN A 1 359 ? -0.455  -31.141 -35.611 1.00 35.29  ? 622  GLN A CG  1 
ATOM   2522 C  CD  . GLN A 1 359 ? -1.392  -31.792 -36.595 1.00 36.61  ? 622  GLN A CD  1 
ATOM   2523 O  OE1 . GLN A 1 359 ? -0.989  -32.303 -37.638 1.00 36.27  ? 622  GLN A OE1 1 
ATOM   2524 N  NE2 . GLN A 1 359 ? -2.676  -31.750 -36.285 1.00 37.66  ? 622  GLN A NE2 1 
ATOM   2525 N  N   . MET A 1 360 ? 1.543   -26.910 -36.207 1.00 38.66  ? 623  MET A N   1 
ATOM   2526 C  CA  . MET A 1 360 ? 2.111   -25.800 -37.040 1.00 46.41  ? 623  MET A CA  1 
ATOM   2527 C  C   . MET A 1 360 ? 3.620   -25.660 -36.724 1.00 40.97  ? 623  MET A C   1 
ATOM   2528 O  O   . MET A 1 360 ? 4.433   -25.597 -37.657 1.00 40.29  ? 623  MET A O   1 
ATOM   2529 C  CB  . MET A 1 360 ? 1.409   -24.471 -36.735 1.00 46.71  ? 623  MET A CB  1 
ATOM   2530 C  CG  . MET A 1 360 ? 0.150   -24.196 -37.543 1.00 48.52  ? 623  MET A CG  1 
ATOM   2531 S  SD  . MET A 1 360 ? -0.574  -22.733 -36.799 1.00 46.78  ? 623  MET A SD  1 
ATOM   2532 C  CE  . MET A 1 360 ? -2.317  -23.145 -36.833 1.00 58.36  ? 623  MET A CE  1 
ATOM   2533 N  N   . GLU A 1 361 ? 3.949   -25.683 -35.442 1.00 34.68  ? 624  GLU A N   1 
ATOM   2534 C  CA  . GLU A 1 361 ? 5.296   -25.539 -34.883 1.00 38.29  ? 624  GLU A CA  1 
ATOM   2535 C  C   . GLU A 1 361 ? 6.183   -26.668 -35.408 1.00 47.63  ? 624  GLU A C   1 
ATOM   2536 O  O   . GLU A 1 361 ? 7.335   -26.367 -35.733 1.00 44.22  ? 624  GLU A O   1 
ATOM   2537 C  CB  . GLU A 1 361 ? 5.258   -25.530 -33.356 1.00 38.12  ? 624  GLU A CB  1 
ATOM   2538 C  CG  . GLU A 1 361 ? 6.644   -25.319 -32.768 1.00 42.01  ? 624  GLU A CG  1 
ATOM   2539 C  CD  . GLU A 1 361 ? 6.710   -24.956 -31.295 1.00 44.66  ? 624  GLU A CD  1 
ATOM   2540 O  OE1 . GLU A 1 361 ? 7.837   -24.893 -30.737 1.00 50.51  ? 624  GLU A OE1 1 
ATOM   2541 O  OE2 . GLU A 1 361 ? 5.643   -24.720 -30.696 1.00 47.21  ? 624  GLU A OE2 1 
ATOM   2542 N  N   . GLY A 1 362 ? 5.697   -27.911 -35.465 1.00 40.45  ? 625  GLY A N   1 
ATOM   2543 C  CA  . GLY A 1 362 ? 6.493   -29.044 -35.970 1.00 42.84  ? 625  GLY A CA  1 
ATOM   2544 C  C   . GLY A 1 362 ? 6.748   -28.940 -37.474 1.00 46.25  ? 625  GLY A C   1 
ATOM   2545 O  O   . GLY A 1 362 ? 7.743   -29.520 -37.982 1.00 47.09  ? 625  GLY A O   1 
ATOM   2546 N  N   . GLU A 1 363 ? 5.848   -28.291 -38.192 1.00 38.86  ? 626  GLU A N   1 
ATOM   2547 C  CA  . GLU A 1 363 ? 5.952   -28.118 -39.653 1.00 42.79  ? 626  GLU A CA  1 
ATOM   2548 C  C   . GLU A 1 363 ? 6.770   -26.834 -39.935 1.00 41.09  ? 626  GLU A C   1 
ATOM   2549 O  O   . GLU A 1 363 ? 6.998   -26.519 -41.088 1.00 44.85  ? 626  GLU A O   1 
ATOM   2550 C  CB  . GLU A 1 363 ? 4.538   -28.132 -40.238 1.00 42.46  ? 626  GLU A CB  1 
ATOM   2551 C  CG  . GLU A 1 363 ? 3.906   -29.543 -40.233 1.00 43.24  ? 626  GLU A CG  1 
ATOM   2552 C  CD  . GLU A 1 363 ? 2.519   -29.666 -40.882 1.00 47.05  ? 626  GLU A CD  1 
ATOM   2553 O  OE1 . GLU A 1 363 ? 2.325   -29.137 -41.987 1.00 41.62  ? 626  GLU A OE1 1 
ATOM   2554 O  OE2 . GLU A 1 363 ? 1.625   -30.305 -40.293 1.00 41.30  ? 626  GLU A OE2 1 
ATOM   2555 N  N   . GLY A 1 364 ? 7.196   -26.101 -38.918 1.00 37.96  ? 627  GLY A N   1 
ATOM   2556 C  CA  . GLY A 1 364 ? 7.926   -24.833 -39.116 1.00 47.28  ? 627  GLY A CA  1 
ATOM   2557 C  C   . GLY A 1 364 ? 7.085   -23.781 -39.834 1.00 59.64  ? 627  GLY A C   1 
ATOM   2558 O  O   . GLY A 1 364 ? 7.633   -23.107 -40.736 1.00 59.42  ? 627  GLY A O   1 
ATOM   2559 N  N   . VAL A 1 365 ? 5.799   -23.628 -39.473 1.00 56.35  ? 628  VAL A N   1 
ATOM   2560 C  CA  . VAL A 1 365 ? 4.905   -22.576 -40.035 1.00 50.73  ? 628  VAL A CA  1 
ATOM   2561 C  C   . VAL A 1 365 ? 5.348   -21.227 -39.459 1.00 54.48  ? 628  VAL A C   1 
ATOM   2562 O  O   . VAL A 1 365 ? 5.270   -20.234 -40.186 1.00 57.25  ? 628  VAL A O   1 
ATOM   2563 C  CB  . VAL A 1 365 ? 3.421   -22.892 -39.769 1.00 51.13  ? 628  VAL A CB  1 
ATOM   2564 C  CG1 . VAL A 1 365 ? 2.504   -21.758 -40.175 1.00 48.84  ? 628  VAL A CG1 1 
ATOM   2565 C  CG2 . VAL A 1 365 ? 3.015   -24.155 -40.500 1.00 48.27  ? 628  VAL A CG2 1 
ATOM   2566 N  N   . PHE A 1 366 ? 5.820   -21.218 -38.214 1.00 49.90  ? 629  PHE A N   1 
ATOM   2567 C  CA  . PHE A 1 366 ? 6.379   -20.042 -37.514 1.00 54.14  ? 629  PHE A CA  1 
ATOM   2568 C  C   . PHE A 1 366 ? 7.673   -20.427 -36.760 1.00 64.15  ? 629  PHE A C   1 
ATOM   2569 O  O   . PHE A 1 366 ? 7.833   -21.570 -36.286 1.00 62.06  ? 629  PHE A O   1 
ATOM   2570 C  CB  . PHE A 1 366 ? 5.337   -19.484 -36.549 1.00 52.75  ? 629  PHE A CB  1 
ATOM   2571 C  CG  . PHE A 1 366 ? 5.050   -20.365 -35.363 1.00 47.78  ? 629  PHE A CG  1 
ATOM   2572 C  CD1 . PHE A 1 366 ? 4.063   -21.336 -35.429 1.00 53.11  ? 629  PHE A CD1 1 
ATOM   2573 C  CD2 . PHE A 1 366 ? 5.741   -20.206 -34.177 1.00 47.62  ? 629  PHE A CD2 1 
ATOM   2574 C  CE1 . PHE A 1 366 ? 3.783   -22.145 -34.338 1.00 49.41  ? 629  PHE A CE1 1 
ATOM   2575 C  CE2 . PHE A 1 366 ? 5.458   -21.012 -33.080 1.00 54.04  ? 629  PHE A CE2 1 
ATOM   2576 C  CZ  . PHE A 1 366 ? 4.487   -21.993 -33.167 1.00 50.90  ? 629  PHE A CZ  1 
ATOM   2577 N  N   . LYS A 1 367 ? 8.571   -19.457 -36.597 1.00 63.84  ? 630  LYS A N   1 
ATOM   2578 C  CA  . LYS A 1 367 ? 9.959   -19.677 -36.125 1.00 67.83  ? 630  LYS A CA  1 
ATOM   2579 C  C   . LYS A 1 367 ? 9.972   -19.502 -34.599 1.00 64.13  ? 630  LYS A C   1 
ATOM   2580 O  O   . LYS A 1 367 ? 10.685  -20.251 -33.923 1.00 61.24  ? 630  LYS A O   1 
ATOM   2581 C  CB  . LYS A 1 367 ? 10.873  -18.725 -36.910 1.00 84.13  ? 630  LYS A CB  1 
ATOM   2582 C  CG  . LYS A 1 367 ? 12.379  -18.907 -36.710 1.00 104.50 ? 630  LYS A CG  1 
ATOM   2583 C  CD  . LYS A 1 367 ? 13.250  -17.917 -37.499 1.00 103.97 ? 630  LYS A CD  1 
ATOM   2584 C  CE  . LYS A 1 367 ? 14.661  -17.768 -36.961 1.00 109.98 ? 630  LYS A CE  1 
ATOM   2585 N  NZ  . LYS A 1 367 ? 14.688  -17.066 -35.655 1.00 112.65 ? 630  LYS A NZ  1 
ATOM   2586 N  N   . SER A 1 368 ? 9.194   -18.569 -34.050 1.00 55.92  ? 631  SER A N   1 
ATOM   2587 C  CA  . SER A 1 368 ? 9.272   -18.233 -32.611 1.00 55.32  ? 631  SER A CA  1 
ATOM   2588 C  C   . SER A 1 368 ? 7.958   -17.649 -32.103 1.00 48.66  ? 631  SER A C   1 
ATOM   2589 O  O   . SER A 1 368 ? 7.325   -16.898 -32.846 1.00 59.17  ? 631  SER A O   1 
ATOM   2590 C  CB  . SER A 1 368 ? 10.398  -17.279 -32.349 1.00 67.58  ? 631  SER A CB  1 
ATOM   2591 O  OG  . SER A 1 368 ? 10.115  -16.460 -31.217 1.00 79.99  ? 631  SER A OG  1 
ATOM   2592 N  N   . ILE A 1 369 ? 7.656   -17.920 -30.833 1.00 48.24  ? 632  ILE A N   1 
ATOM   2593 C  CA  . ILE A 1 369 ? 6.399   -17.565 -30.119 1.00 60.28  ? 632  ILE A CA  1 
ATOM   2594 C  C   . ILE A 1 369 ? 6.533   -16.185 -29.493 1.00 63.38  ? 632  ILE A C   1 
ATOM   2595 O  O   . ILE A 1 369 ? 5.516   -15.717 -28.877 1.00 53.53  ? 632  ILE A O   1 
ATOM   2596 C  CB  . ILE A 1 369 ? 6.074   -18.590 -29.017 1.00 57.06  ? 632  ILE A CB  1 
ATOM   2597 C  CG1 . ILE A 1 369 ? 7.177   -18.651 -27.962 1.00 56.22  ? 632  ILE A CG1 1 
ATOM   2598 C  CG2 . ILE A 1 369 ? 5.789   -19.952 -29.628 1.00 67.35  ? 632  ILE A CG2 1 
ATOM   2599 C  CD1 . ILE A 1 369 ? 6.730   -19.241 -26.670 1.00 58.92  ? 632  ILE A CD1 1 
ATOM   2600 N  N   . GLN A 1 370 ? 7.751   -15.629 -29.511 1.00 70.41  ? 633  GLN A N   1 
ATOM   2601 C  CA  . GLN A 1 370 ? 8.058   -14.334 -28.840 1.00 73.91  ? 633  GLN A CA  1 
ATOM   2602 C  C   . GLN A 1 370 ? 7.226   -13.245 -29.528 1.00 70.04  ? 633  GLN A C   1 
ATOM   2603 O  O   . GLN A 1 370 ? 6.621   -12.404 -28.842 1.00 61.08  ? 633  GLN A O   1 
ATOM   2604 C  CB  . GLN A 1 370 ? 9.559   -14.032 -28.895 1.00 71.42  ? 633  GLN A CB  1 
ATOM   2605 C  CG  . GLN A 1 370 ? 10.091  -13.430 -27.599 1.00 75.38  ? 633  GLN A CG  1 
ATOM   2606 C  CD  . GLN A 1 370 ? 10.286  -14.465 -26.521 1.00 77.20  ? 633  GLN A CD  1 
ATOM   2607 O  OE1 . GLN A 1 370 ? 10.540  -15.630 -26.809 1.00 83.15  ? 633  GLN A OE1 1 
ATOM   2608 N  NE2 . GLN A 1 370 ? 10.159  -14.049 -25.269 1.00 82.45  ? 633  GLN A NE2 1 
ATOM   2609 N  N   . HIS A 1 371 ? 7.186   -13.291 -30.862 0.50 69.90  ? 634  HIS A N   1 
ATOM   2610 C  CA  . HIS A 1 371 ? 6.478   -12.319 -31.733 0.50 76.13  ? 634  HIS A CA  1 
ATOM   2611 C  C   . HIS A 1 371 ? 6.297   -12.933 -33.126 0.50 75.47  ? 634  HIS A C   1 
ATOM   2612 O  O   . HIS A 1 371 ? 7.246   -13.568 -33.629 0.50 76.95  ? 634  HIS A O   1 
ATOM   2613 C  CB  . HIS A 1 371 ? 7.240   -10.984 -31.756 0.50 83.37  ? 634  HIS A CB  1 
ATOM   2614 C  CG  . HIS A 1 371 ? 7.133   -10.239 -33.045 0.50 90.71  ? 634  HIS A CG  1 
ATOM   2615 N  ND1 . HIS A 1 371 ? 6.076   -9.386  -33.325 0.50 95.37  ? 634  HIS A ND1 1 
ATOM   2616 C  CD2 . HIS A 1 371 ? 7.945   -10.207 -34.126 0.50 94.15  ? 634  HIS A CD2 1 
ATOM   2617 C  CE1 . HIS A 1 371 ? 6.242   -8.864  -34.525 0.50 97.53  ? 634  HIS A CE1 1 
ATOM   2618 N  NE2 . HIS A 1 371 ? 7.382   -9.355  -35.039 0.50 99.37  ? 634  HIS A NE2 1 
ATOM   2619 N  N   . LEU A 1 372 ? 5.112   -12.757 -33.713 0.50 76.62  ? 635  LEU A N   1 
ATOM   2620 C  CA  . LEU A 1 372 ? 4.768   -13.240 -35.074 0.50 75.61  ? 635  LEU A CA  1 
ATOM   2621 C  C   . LEU A 1 372 ? 4.945   -12.079 -36.058 0.50 72.30  ? 635  LEU A C   1 
ATOM   2622 O  O   . LEU A 1 372 ? 4.337   -11.021 -35.825 0.50 74.31  ? 635  LEU A O   1 
ATOM   2623 C  CB  . LEU A 1 372 ? 3.322   -13.753 -35.063 0.50 77.02  ? 635  LEU A CB  1 
ATOM   2624 C  CG  . LEU A 1 372 ? 3.054   -15.004 -35.898 0.50 76.10  ? 635  LEU A CG  1 
ATOM   2625 C  CD1 . LEU A 1 372 ? 3.863   -16.180 -35.374 0.50 76.81  ? 635  LEU A CD1 1 
ATOM   2626 C  CD2 . LEU A 1 372 ? 1.572   -15.342 -35.911 0.50 76.27  ? 635  LEU A CD2 1 
ATOM   2627 N  N   . THR A 1 373 ? 5.763   -12.263 -37.097 0.50 69.67  ? 636  THR A N   1 
ATOM   2628 C  CA  . THR A 1 373 ? 5.917   -11.295 -38.213 0.50 70.99  ? 636  THR A CA  1 
ATOM   2629 C  C   . THR A 1 373 ? 4.567   -11.181 -38.925 0.50 72.97  ? 636  THR A C   1 
ATOM   2630 O  O   . THR A 1 373 ? 3.684   -12.006 -38.631 0.50 74.61  ? 636  THR A O   1 
ATOM   2631 C  CB  . THR A 1 373 ? 7.045   -11.718 -39.161 0.50 70.63  ? 636  THR A CB  1 
ATOM   2632 O  OG1 . THR A 1 373 ? 6.555   -12.762 -40.000 0.50 73.57  ? 636  THR A OG1 1 
ATOM   2633 C  CG2 . THR A 1 373 ? 8.282   -12.189 -38.429 0.50 71.17  ? 636  THR A CG2 1 
ATOM   2634 N  N   . VAL A 1 374 ? 4.408   -10.202 -39.816 0.50 73.51  ? 637  VAL A N   1 
ATOM   2635 C  CA  . VAL A 1 374 ? 3.150   -9.991  -40.591 0.50 78.08  ? 637  VAL A CA  1 
ATOM   2636 C  C   . VAL A 1 374 ? 3.004   -11.135 -41.599 0.50 80.15  ? 637  VAL A C   1 
ATOM   2637 O  O   . VAL A 1 374 ? 1.867   -11.623 -41.784 0.50 77.00  ? 637  VAL A O   1 
ATOM   2638 C  CB  . VAL A 1 374 ? 3.138   -8.620  -41.290 0.50 79.24  ? 637  VAL A CB  1 
ATOM   2639 C  CG1 . VAL A 1 374 ? 2.908   -7.492  -40.295 0.50 79.62  ? 637  VAL A CG1 1 
ATOM   2640 C  CG2 . VAL A 1 374 ? 4.410   -8.387  -42.093 0.50 80.12  ? 637  VAL A CG2 1 
ATOM   2641 N  N   . THR A 1 375 ? 4.118   -11.546 -42.214 0.50 78.57  ? 638  THR A N   1 
ATOM   2642 C  CA  . THR A 1 375 ? 4.171   -12.621 -43.241 0.50 81.24  ? 638  THR A CA  1 
ATOM   2643 C  C   . THR A 1 375 ? 3.934   -13.984 -42.575 0.50 79.21  ? 638  THR A C   1 
ATOM   2644 O  O   . THR A 1 375 ? 3.353   -14.865 -43.243 0.50 75.96  ? 638  THR A O   1 
ATOM   2645 C  CB  . THR A 1 375 ? 5.498   -12.606 -44.009 0.50 82.97  ? 638  THR A CB  1 
ATOM   2646 O  OG1 . THR A 1 375 ? 6.544   -12.922 -43.091 0.50 87.54  ? 638  THR A OG1 1 
ATOM   2647 C  CG2 . THR A 1 375 ? 5.780   -11.277 -44.676 0.50 85.73  ? 638  THR A CG2 1 
ATOM   2648 N  N   . GLU A 1 376 ? 4.384   -14.159 -41.326 0.50 73.89  ? 639  GLU A N   1 
ATOM   2649 C  CA  . GLU A 1 376 ? 4.131   -15.390 -40.528 0.50 70.97  ? 639  GLU A CA  1 
ATOM   2650 C  C   . GLU A 1 376 ? 2.617   -15.510 -40.318 0.50 67.02  ? 639  GLU A C   1 
ATOM   2651 O  O   . GLU A 1 376 ? 2.071   -16.582 -40.634 0.50 58.38  ? 639  GLU A O   1 
ATOM   2652 C  CB  . GLU A 1 376 ? 4.918   -15.382 -39.215 0.50 68.34  ? 639  GLU A CB  1 
ATOM   2653 C  CG  . GLU A 1 376 ? 6.267   -16.079 -39.319 0.50 66.92  ? 639  GLU A CG  1 
ATOM   2654 C  CD  . GLU A 1 376 ? 7.140   -16.010 -38.074 0.50 67.60  ? 639  GLU A CD  1 
ATOM   2655 O  OE1 . GLU A 1 376 ? 7.974   -16.920 -37.888 0.50 69.10  ? 639  GLU A OE1 1 
ATOM   2656 O  OE2 . GLU A 1 376 ? 6.997   -15.044 -37.297 0.50 65.85  ? 639  GLU A OE2 1 
ATOM   2657 N  N   . GLU A 1 377 ? 1.968   -14.433 -39.860 0.50 66.16  ? 640  GLU A N   1 
ATOM   2658 C  CA  . GLU A 1 377 ? 0.491   -14.367 -39.691 0.50 68.91  ? 640  GLU A CA  1 
ATOM   2659 C  C   . GLU A 1 377 ? -0.174  -14.911 -40.957 0.50 69.49  ? 640  GLU A C   1 
ATOM   2660 O  O   . GLU A 1 377 ? -0.917  -15.899 -40.856 0.50 75.09  ? 640  GLU A O   1 
ATOM   2661 C  CB  . GLU A 1 377 ? 0.023   -12.942 -39.400 0.50 70.73  ? 640  GLU A CB  1 
ATOM   2662 C  CG  . GLU A 1 377 ? 0.309   -12.500 -37.979 0.50 75.86  ? 640  GLU A CG  1 
ATOM   2663 C  CD  . GLU A 1 377 ? -0.555  -11.349 -37.493 0.50 79.53  ? 640  GLU A CD  1 
ATOM   2664 O  OE1 . GLU A 1 377 ? -1.669  -11.181 -38.034 0.50 83.99  ? 640  GLU A OE1 1 
ATOM   2665 O  OE2 . GLU A 1 377 ? -0.115  -10.628 -36.573 0.50 82.57  ? 640  GLU A OE2 1 
ATOM   2666 N  N   . ILE A 1 378 ? 0.096   -14.299 -42.110 0.50 69.49  ? 641  ILE A N   1 
ATOM   2667 C  CA  . ILE A 1 378 ? -0.481  -14.733 -43.418 0.50 70.71  ? 641  ILE A CA  1 
ATOM   2668 C  C   . ILE A 1 378 ? -0.155  -16.219 -43.631 0.50 66.27  ? 641  ILE A C   1 
ATOM   2669 O  O   . ILE A 1 378 ? -1.057  -16.949 -44.078 0.50 68.41  ? 641  ILE A O   1 
ATOM   2670 C  CB  . ILE A 1 378 ? -0.001  -13.827 -44.575 0.50 70.60  ? 641  ILE A CB  1 
ATOM   2671 C  CG1 . ILE A 1 378 ? 0.051   -14.566 -45.914 0.50 70.02  ? 641  ILE A CG1 1 
ATOM   2672 C  CG2 . ILE A 1 378 ? 1.336   -13.183 -44.243 0.50 73.88  ? 641  ILE A CG2 1 
ATOM   2673 C  CD1 . ILE A 1 378 ? 1.387   -15.217 -46.203 0.50 73.93  ? 641  ILE A CD1 1 
ATOM   2674 N  N   . ALA A 1 379 ? 1.063   -16.659 -43.293 1.00 61.71  ? 642  ALA A N   1 
ATOM   2675 C  CA  . ALA A 1 379 ? 1.503   -18.073 -43.499 1.00 66.09  ? 642  ALA A CA  1 
ATOM   2676 C  C   . ALA A 1 379 ? 0.669   -19.058 -42.642 1.00 57.24  ? 642  ALA A C   1 
ATOM   2677 O  O   . ALA A 1 379 ? 0.252   -20.093 -43.197 1.00 46.19  ? 642  ALA A O   1 
ATOM   2678 C  CB  . ALA A 1 379 ? 2.988   -18.248 -43.252 1.00 59.46  ? 642  ALA A CB  1 
ATOM   2679 N  N   . VAL A 1 380 ? 0.419   -18.712 -41.373 1.00 45.99  ? 643  VAL A N   1 
ATOM   2680 C  CA  . VAL A 1 380 ? -0.467  -19.438 -40.428 1.00 51.45  ? 643  VAL A CA  1 
ATOM   2681 C  C   . VAL A 1 380 ? -1.877  -19.492 -41.038 1.00 57.30  ? 643  VAL A C   1 
ATOM   2682 O  O   . VAL A 1 380 ? -2.445  -20.609 -41.144 1.00 47.99  ? 643  VAL A O   1 
ATOM   2683 C  CB  . VAL A 1 380 ? -0.434  -18.796 -39.030 1.00 49.12  ? 643  VAL A CB  1 
ATOM   2684 C  CG1 . VAL A 1 380 ? -1.573  -19.287 -38.149 1.00 48.69  ? 643  VAL A CG1 1 
ATOM   2685 C  CG2 . VAL A 1 380 ? 0.896   -19.064 -38.342 1.00 51.72  ? 643  VAL A CG2 1 
ATOM   2686 N  N   . LYS A 1 381 ? -2.390  -18.349 -41.503 1.00 54.00  ? 644  LYS A N   1 
ATOM   2687 C  CA  . LYS A 1 381 ? -3.756  -18.245 -42.071 1.00 51.42  ? 644  LYS A CA  1 
ATOM   2688 C  C   . LYS A 1 381 ? -3.866  -19.160 -43.291 1.00 51.78  ? 644  LYS A C   1 
ATOM   2689 O  O   . LYS A 1 381 ? -4.888  -19.908 -43.399 1.00 54.24  ? 644  LYS A O   1 
ATOM   2690 C  CB  . LYS A 1 381 ? -4.125  -16.789 -42.362 1.00 58.32  ? 644  LYS A CB  1 
ATOM   2691 C  CG  . LYS A 1 381 ? -4.383  -15.965 -41.110 1.00 69.31  ? 644  LYS A CG  1 
ATOM   2692 C  CD  . LYS A 1 381 ? -4.508  -14.455 -41.308 1.00 74.77  ? 644  LYS A CD  1 
ATOM   2693 C  CE  . LYS A 1 381 ? -4.174  -13.681 -40.046 1.00 75.77  ? 644  LYS A CE  1 
ATOM   2694 N  NZ  . LYS A 1 381 ? -4.848  -12.364 -40.007 1.00 84.32  ? 644  LYS A NZ  1 
ATOM   2695 N  N   . ASN A 1 382 ? -2.862  -19.132 -44.176 0.50 50.95  ? 645  ASN A N   1 
ATOM   2696 C  CA  . ASN A 1 382 ? -2.849  -19.907 -45.449 0.50 53.81  ? 645  ASN A CA  1 
ATOM   2697 C  C   . ASN A 1 382 ? -2.787  -21.406 -45.139 0.50 52.60  ? 645  ASN A C   1 
ATOM   2698 O  O   . ASN A 1 382 ? -3.495  -22.185 -45.813 0.50 51.47  ? 645  ASN A O   1 
ATOM   2699 C  CB  . ASN A 1 382 ? -1.689  -19.502 -46.365 0.50 58.72  ? 645  ASN A CB  1 
ATOM   2700 C  CG  . ASN A 1 382 ? -2.135  -18.670 -47.549 0.50 62.10  ? 645  ASN A CG  1 
ATOM   2701 O  OD1 . ASN A 1 382 ? -3.261  -18.811 -48.024 0.50 62.35  ? 645  ASN A OD1 1 
ATOM   2702 N  ND2 . ASN A 1 382 ? -1.259  -17.803 -48.036 0.50 65.55  ? 645  ASN A ND2 1 
ATOM   2703 N  N   . TRP A 1 383 ? -1.950  -21.790 -44.170 0.50 52.79  ? 646  TRP A N   1 
ATOM   2704 C  CA  . TRP A 1 383 ? -1.841  -23.184 -43.660 0.50 48.50  ? 646  TRP A CA  1 
ATOM   2705 C  C   . TRP A 1 383 ? -3.243  -23.661 -43.260 0.50 43.49  ? 646  TRP A C   1 
ATOM   2706 O  O   . TRP A 1 383 ? -3.735  -24.638 -43.858 0.50 39.56  ? 646  TRP A O   1 
ATOM   2707 C  CB  . TRP A 1 383 ? -0.840  -23.233 -42.500 0.50 47.22  ? 646  TRP A CB  1 
ATOM   2708 C  CG  . TRP A 1 383 ? -0.501  -24.604 -42.004 0.50 49.97  ? 646  TRP A CG  1 
ATOM   2709 C  CD1 . TRP A 1 383 ? 0.470   -25.439 -42.477 0.50 50.01  ? 646  TRP A CD1 1 
ATOM   2710 C  CD2 . TRP A 1 383 ? -1.110  -25.291 -40.896 0.50 50.04  ? 646  TRP A CD2 1 
ATOM   2711 N  NE1 . TRP A 1 383 ? 0.501   -26.599 -41.748 0.50 49.10  ? 646  TRP A NE1 1 
ATOM   2712 C  CE2 . TRP A 1 383 ? -0.453  -26.534 -40.768 0.50 50.20  ? 646  TRP A CE2 1 
ATOM   2713 C  CE3 . TRP A 1 383 ? -2.134  -24.974 -39.999 0.50 48.48  ? 646  TRP A CE3 1 
ATOM   2714 C  CZ2 . TRP A 1 383 ? -0.797  -27.457 -39.784 0.50 49.17  ? 646  TRP A CZ2 1 
ATOM   2715 C  CZ3 . TRP A 1 383 ? -2.471  -25.888 -39.025 0.50 48.40  ? 646  TRP A CZ3 1 
ATOM   2716 C  CH2 . TRP A 1 383 ? -1.808  -27.109 -38.919 0.50 48.75  ? 646  TRP A CH2 1 
ATOM   2717 N  N   . LEU A 1 384 ? -3.885  -22.935 -42.344 0.50 42.08  ? 647  LEU A N   1 
ATOM   2718 C  CA  . LEU A 1 384 ? -5.239  -23.248 -41.822 0.50 46.06  ? 647  LEU A CA  1 
ATOM   2719 C  C   . LEU A 1 384 ? -6.227  -23.414 -42.984 0.50 48.41  ? 647  LEU A C   1 
ATOM   2720 O  O   . LEU A 1 384 ? -7.029  -24.362 -42.954 0.50 47.20  ? 647  LEU A O   1 
ATOM   2721 C  CB  . LEU A 1 384 ? -5.669  -22.130 -40.871 0.50 44.44  ? 647  LEU A CB  1 
ATOM   2722 C  CG  . LEU A 1 384 ? -5.067  -22.220 -39.471 0.50 47.09  ? 647  LEU A CG  1 
ATOM   2723 C  CD1 . LEU A 1 384 ? -5.369  -20.970 -38.658 0.50 46.73  ? 647  LEU A CD1 1 
ATOM   2724 C  CD2 . LEU A 1 384 ? -5.558  -23.464 -38.744 0.50 47.56  ? 647  LEU A CD2 1 
ATOM   2725 N  N   . VAL A 1 385 ? -6.160  -22.535 -43.983 0.50 53.66  ? 648  VAL A N   1 
ATOM   2726 C  CA  . VAL A 1 385 ? -7.108  -22.526 -45.133 0.50 52.01  ? 648  VAL A CA  1 
ATOM   2727 C  C   . VAL A 1 385 ? -6.747  -23.683 -46.067 0.50 51.91  ? 648  VAL A C   1 
ATOM   2728 O  O   . VAL A 1 385 ? -7.666  -24.357 -46.568 0.50 54.10  ? 648  VAL A O   1 
ATOM   2729 C  CB  . VAL A 1 385 ? -7.088  -21.163 -45.851 0.50 55.09  ? 648  VAL A CB  1 
ATOM   2730 C  CG1 . VAL A 1 385 ? -7.645  -21.251 -47.264 0.50 55.31  ? 648  VAL A CG1 1 
ATOM   2731 C  CG2 . VAL A 1 385 ? -7.830  -20.105 -45.045 0.50 55.78  ? 648  VAL A CG2 1 
ATOM   2732 N  N   . ARG A 1 386 ? -5.454  -23.930 -46.259 0.50 52.58  ? 649  ARG A N   1 
ATOM   2733 C  CA  . ARG A 1 386 ? -4.949  -24.911 -47.253 0.50 53.58  ? 649  ARG A CA  1 
ATOM   2734 C  C   . ARG A 1 386 ? -5.000  -26.335 -46.665 0.50 51.46  ? 649  ARG A C   1 
ATOM   2735 O  O   . ARG A 1 386 ? -5.353  -27.267 -47.421 0.50 49.11  ? 649  ARG A O   1 
ATOM   2736 C  CB  . ARG A 1 386 ? -3.554  -24.466 -47.714 0.50 59.61  ? 649  ARG A CB  1 
ATOM   2737 C  CG  . ARG A 1 386 ? -2.692  -25.566 -48.320 0.50 66.14  ? 649  ARG A CG  1 
ATOM   2738 C  CD  . ARG A 1 386 ? -1.315  -25.083 -48.768 0.50 69.90  ? 649  ARG A CD  1 
ATOM   2739 N  NE  . ARG A 1 386 ? -0.241  -25.277 -47.791 0.50 70.54  ? 649  ARG A NE  1 
ATOM   2740 C  CZ  . ARG A 1 386 ? 0.212   -24.344 -46.953 0.50 69.35  ? 649  ARG A CZ  1 
ATOM   2741 N  NH1 . ARG A 1 386 ? -0.321  -23.134 -46.947 0.50 71.33  ? 649  ARG A NH1 1 
ATOM   2742 N  NH2 . ARG A 1 386 ? 1.193   -24.628 -46.116 0.50 68.38  ? 649  ARG A NH2 1 
ATOM   2743 N  N   . VAL A 1 387 ? -4.663  -26.520 -45.382 1.00 47.89  ? 650  VAL A N   1 
ATOM   2744 C  CA  . VAL A 1 387 ? -4.527  -27.901 -44.800 1.00 48.90  ? 650  VAL A CA  1 
ATOM   2745 C  C   . VAL A 1 387 ? -5.204  -28.100 -43.438 1.00 40.35  ? 650  VAL A C   1 
ATOM   2746 O  O   . VAL A 1 387 ? -5.101  -29.271 -42.949 1.00 40.45  ? 650  VAL A O   1 
ATOM   2747 C  CB  . VAL A 1 387 ? -3.045  -28.326 -44.675 1.00 43.60  ? 650  VAL A CB  1 
ATOM   2748 C  CG1 . VAL A 1 387 ? -2.381  -28.419 -46.021 1.00 45.94  ? 650  VAL A CG1 1 
ATOM   2749 C  CG2 . VAL A 1 387 ? -2.273  -27.429 -43.718 1.00 44.03  ? 650  VAL A CG2 1 
ATOM   2750 N  N   . GLY A 1 388 ? -5.824  -27.067 -42.854 1.00 39.52  ? 651  GLY A N   1 
ATOM   2751 C  CA  . GLY A 1 388 ? -6.441  -27.113 -41.511 1.00 38.51  ? 651  GLY A CA  1 
ATOM   2752 C  C   . GLY A 1 388 ? -7.346  -28.329 -41.360 1.00 41.57  ? 651  GLY A C   1 
ATOM   2753 O  O   . GLY A 1 388 ? -7.220  -29.064 -40.394 1.00 43.36  ? 651  GLY A O   1 
ATOM   2754 N  N   . ARG A 1 389 ? -8.214  -28.569 -42.322 1.00 40.13  ? 652  ARG A N   1 
ATOM   2755 C  CA  . ARG A 1 389 ? -9.211  -29.657 -42.238 1.00 44.15  ? 652  ARG A CA  1 
ATOM   2756 C  C   . ARG A 1 389 ? -8.461  -30.984 -42.239 1.00 39.53  ? 652  ARG A C   1 
ATOM   2757 O  O   . ARG A 1 389 ? -8.840  -31.888 -41.460 1.00 42.56  ? 652  ARG A O   1 
ATOM   2758 C  CB  . ARG A 1 389 ? -10.271 -29.569 -43.355 1.00 42.59  ? 652  ARG A CB  1 
ATOM   2759 C  CG  . ARG A 1 389 ? -11.274 -28.439 -43.146 1.00 44.27  ? 652  ARG A CG  1 
ATOM   2760 C  CD  . ARG A 1 389 ? -12.331 -28.351 -44.238 1.00 46.69  ? 652  ARG A CD  1 
ATOM   2761 N  NE  . ARG A 1 389 ? -13.252 -29.471 -44.210 1.00 47.01  ? 652  ARG A NE  1 
ATOM   2762 C  CZ  . ARG A 1 389 ? -14.297 -29.562 -43.392 1.00 48.40  ? 652  ARG A CZ  1 
ATOM   2763 N  NH1 . ARG A 1 389 ? -14.569 -28.606 -42.515 1.00 51.15  ? 652  ARG A NH1 1 
ATOM   2764 N  NH2 . ARG A 1 389 ? -15.033 -30.655 -43.410 1.00 49.19  ? 652  ARG A NH2 1 
ATOM   2765 N  N   . GLU A 1 390 ? -7.447  -31.125 -43.098 0.50 37.95  ? 653  GLU A N   1 
ATOM   2766 C  CA  . GLU A 1 390 ? -6.635  -32.374 -43.168 0.50 38.33  ? 653  GLU A CA  1 
ATOM   2767 C  C   . GLU A 1 390 ? -5.974  -32.608 -41.802 0.50 37.47  ? 653  GLU A C   1 
ATOM   2768 O  O   . GLU A 1 390 ? -6.050  -33.738 -41.304 0.50 38.62  ? 653  GLU A O   1 
ATOM   2769 C  CB  . GLU A 1 390 ? -5.583  -32.310 -44.274 0.50 36.99  ? 653  GLU A CB  1 
ATOM   2770 C  CG  . GLU A 1 390 ? -4.955  -33.663 -44.566 0.50 37.29  ? 653  GLU A CG  1 
ATOM   2771 C  CD  . GLU A 1 390 ? -3.893  -34.163 -43.589 0.50 36.88  ? 653  GLU A CD  1 
ATOM   2772 O  OE1 . GLU A 1 390 ? -3.375  -33.360 -42.773 0.50 33.23  ? 653  GLU A OE1 1 
ATOM   2773 O  OE2 . GLU A 1 390 ? -3.574  -35.370 -43.650 0.50 39.02  ? 653  GLU A OE2 1 
ATOM   2774 N  N   . ARG A 1 391 ? -5.412  -31.552 -41.209 1.00 34.90  ? 654  ARG A N   1 
ATOM   2775 C  CA  . ARG A 1 391 ? -4.703  -31.628 -39.913 1.00 39.11  ? 654  ARG A CA  1 
ATOM   2776 C  C   . ARG A 1 391 ? -5.658  -32.022 -38.765 1.00 34.92  ? 654  ARG A C   1 
ATOM   2777 O  O   . ARG A 1 391 ? -5.240  -32.780 -37.873 1.00 34.91  ? 654  ARG A O   1 
ATOM   2778 C  CB  . ARG A 1 391 ? -3.895  -30.340 -39.715 1.00 40.42  ? 654  ARG A CB  1 
ATOM   2779 C  CG  . ARG A 1 391 ? -2.893  -30.078 -40.843 1.00 41.70  ? 654  ARG A CG  1 
ATOM   2780 C  CD  . ARG A 1 391 ? -1.729  -31.048 -40.866 1.00 42.85  ? 654  ARG A CD  1 
ATOM   2781 N  NE  . ARG A 1 391 ? -0.656  -30.580 -41.727 1.00 47.52  ? 654  ARG A NE  1 
ATOM   2782 C  CZ  . ARG A 1 391 ? -0.506  -30.872 -43.021 1.00 49.84  ? 654  ARG A CZ  1 
ATOM   2783 N  NH1 . ARG A 1 391 ? -1.347  -31.656 -43.665 1.00 51.61  ? 654  ARG A NH1 1 
ATOM   2784 N  NH2 . ARG A 1 391 ? 0.505   -30.366 -43.691 1.00 60.13  ? 654  ARG A NH2 1 
ATOM   2785 N  N   . LEU A 1 392 ? -6.907  -31.546 -38.795 0.50 34.51  ? 655  LEU A N   1 
ATOM   2786 C  CA  . LEU A 1 392 ? -7.950  -31.893 -37.782 0.50 34.79  ? 655  LEU A CA  1 
ATOM   2787 C  C   . LEU A 1 392 ? -8.349  -33.375 -37.905 0.50 32.99  ? 655  LEU A C   1 
ATOM   2788 O  O   . LEU A 1 392 ? -8.656  -34.008 -36.839 0.50 32.28  ? 655  LEU A O   1 
ATOM   2789 C  CB  . LEU A 1 392 ? -9.183  -31.004 -37.965 0.50 34.98  ? 655  LEU A CB  1 
ATOM   2790 C  CG  . LEU A 1 392 ? -9.033  -29.553 -37.520 0.50 35.57  ? 655  LEU A CG  1 
ATOM   2791 C  CD1 . LEU A 1 392 ? -10.308 -28.778 -37.805 0.50 38.09  ? 655  LEU A CD1 1 
ATOM   2792 C  CD2 . LEU A 1 392 ? -8.662  -29.458 -36.047 0.50 36.11  ? 655  LEU A CD2 1 
ATOM   2793 N  N   . SER A 1 393 ? -8.301  -33.917 -39.134 1.00 32.67  ? 656  SER A N   1 
ATOM   2794 C  CA  . SER A 1 393 ? -8.622  -35.328 -39.382 1.00 34.59  ? 656  SER A CA  1 
ATOM   2795 C  C   . SER A 1 393 ? -7.530  -36.265 -38.867 1.00 37.94  ? 656  SER A C   1 
ATOM   2796 O  O   . SER A 1 393 ? -7.787  -37.471 -38.803 1.00 33.71  ? 656  SER A O   1 
ATOM   2797 C  CB  . SER A 1 393 ? -8.920  -35.565 -40.835 1.00 39.64  ? 656  SER A CB  1 
ATOM   2798 O  OG  . SER A 1 393 ? -7.732  -35.539 -41.613 1.00 47.48  ? 656  SER A OG  1 
ATOM   2799 N  N   . ARG A 1 394 ? -6.358  -35.722 -38.502 0.50 35.78  ? 657  ARG A N   1 
ATOM   2800 C  CA  . ARG A 1 394 ? -5.185  -36.498 -38.016 0.50 35.63  ? 657  ARG A CA  1 
ATOM   2801 C  C   . ARG A 1 394 ? -5.252  -36.621 -36.497 0.50 33.56  ? 657  ARG A C   1 
ATOM   2802 O  O   . ARG A 1 394 ? -4.263  -37.092 -35.894 0.50 31.82  ? 657  ARG A O   1 
ATOM   2803 C  CB  . ARG A 1 394 ? -3.875  -35.786 -38.359 0.50 37.97  ? 657  ARG A CB  1 
ATOM   2804 C  CG  . ARG A 1 394 ? -3.574  -35.769 -39.845 0.50 39.16  ? 657  ARG A CG  1 
ATOM   2805 C  CD  . ARG A 1 394 ? -2.261  -35.108 -40.190 0.50 39.99  ? 657  ARG A CD  1 
ATOM   2806 N  NE  . ARG A 1 394 ? -1.984  -35.539 -41.542 0.50 41.20  ? 657  ARG A NE  1 
ATOM   2807 C  CZ  . ARG A 1 394 ? -1.277  -36.611 -41.843 0.50 44.16  ? 657  ARG A CZ  1 
ATOM   2808 N  NH1 . ARG A 1 394 ? -0.721  -37.326 -40.881 0.50 45.05  ? 657  ARG A NH1 1 
ATOM   2809 N  NH2 . ARG A 1 394 ? -1.116  -36.959 -43.106 0.50 46.67  ? 657  ARG A NH2 1 
ATOM   2810 N  N   . MET A 1 395 ? -6.350  -36.166 -35.897 0.50 30.88  ? 658  MET A N   1 
ATOM   2811 C  CA  . MET A 1 395 ? -6.490  -36.140 -34.422 0.50 30.24  ? 658  MET A CA  1 
ATOM   2812 C  C   . MET A 1 395 ? -7.818  -36.771 -33.979 0.50 29.77  ? 658  MET A C   1 
ATOM   2813 O  O   . MET A 1 395 ? -8.796  -36.711 -34.736 0.50 29.23  ? 658  MET A O   1 
ATOM   2814 C  CB  . MET A 1 395 ? -6.382  -34.697 -33.931 0.50 30.58  ? 658  MET A CB  1 
ATOM   2815 C  CG  . MET A 1 395 ? -5.057  -34.042 -34.315 0.50 31.55  ? 658  MET A CG  1 
ATOM   2816 S  SD  . MET A 1 395 ? -4.911  -32.330 -33.731 0.50 32.01  ? 658  MET A SD  1 
ATOM   2817 C  CE  . MET A 1 395 ? -6.246  -31.541 -34.631 0.50 31.68  ? 658  MET A CE  1 
ATOM   2818 N  N   . ALA A 1 396 ? -7.812  -37.376 -32.790 1.00 29.23  ? 659  ALA A N   1 
ATOM   2819 C  CA  . ALA A 1 396 ? -9.011  -37.787 -32.044 1.00 28.96  ? 659  ALA A CA  1 
ATOM   2820 C  C   . ALA A 1 396 ? -8.944  -37.016 -30.711 1.00 29.70  ? 659  ALA A C   1 
ATOM   2821 O  O   . ALA A 1 396 ? -8.011  -37.245 -29.986 1.00 25.68  ? 659  ALA A O   1 
ATOM   2822 C  CB  . ALA A 1 396 ? -9.018  -39.284 -31.849 1.00 29.54  ? 659  ALA A CB  1 
ATOM   2823 N  N   . ILE A 1 397 ? -9.913  -36.151 -30.400 1.00 28.14  ? 660  ILE A N   1 
ATOM   2824 C  CA  . ILE A 1 397 ? -9.879  -35.269 -29.213 1.00 27.87  ? 660  ILE A CA  1 
ATOM   2825 C  C   . ILE A 1 397 ? -11.191 -35.411 -28.456 1.00 31.70  ? 660  ILE A C   1 
ATOM   2826 O  O   . ILE A 1 397 ? -12.250 -35.202 -29.062 1.00 28.76  ? 660  ILE A O   1 
ATOM   2827 C  CB  . ILE A 1 397 ? -9.590  -33.821 -29.638 1.00 30.60  ? 660  ILE A CB  1 
ATOM   2828 C  CG1 . ILE A 1 397 ? -8.316  -33.801 -30.483 1.00 33.16  ? 660  ILE A CG1 1 
ATOM   2829 C  CG2 . ILE A 1 397 ? -9.539  -32.910 -28.429 1.00 31.80  ? 660  ILE A CG2 1 
ATOM   2830 C  CD1 . ILE A 1 397 ? -7.586  -32.502 -30.570 1.00 33.63  ? 660  ILE A CD1 1 
ATOM   2831 N  N   . SER A 1 398 ? -11.096 -35.761 -27.173 1.00 30.27  ? 661  SER A N   1 
ATOM   2832 C  CA  . SER A 1 398 ? -12.230 -35.873 -26.249 1.00 32.75  ? 661  SER A CA  1 
ATOM   2833 C  C   . SER A 1 398 ? -11.927 -35.013 -25.040 1.00 32.67  ? 661  SER A C   1 
ATOM   2834 O  O   . SER A 1 398 ? -11.171 -35.490 -24.179 1.00 35.45  ? 661  SER A O   1 
ATOM   2835 C  CB  . SER A 1 398 ? -12.485 -37.295 -25.855 1.00 33.00  ? 661  SER A CB  1 
ATOM   2836 O  OG  . SER A 1 398 ? -13.762 -37.378 -25.237 1.00 33.68  ? 661  SER A OG  1 
ATOM   2837 N  N   . GLY A 1 399 ? -12.433 -33.781 -25.014 1.00 28.17  ? 662  GLY A N   1 
ATOM   2838 C  CA  . GLY A 1 399 ? -12.088 -32.852 -23.920 1.00 31.27  ? 662  GLY A CA  1 
ATOM   2839 C  C   . GLY A 1 399 ? -10.575 -32.704 -23.801 1.00 31.42  ? 662  GLY A C   1 
ATOM   2840 O  O   . GLY A 1 399 ? -9.922  -32.399 -24.817 1.00 31.51  ? 662  GLY A O   1 
ATOM   2841 N  N   . ASP A 1 400 ? -10.015 -32.923 -22.613 1.00 33.53  ? 663  ASP A N   1 
ATOM   2842 C  CA  . ASP A 1 400 ? -8.570  -32.715 -22.360 1.00 37.87  ? 663  ASP A CA  1 
ATOM   2843 C  C   . ASP A 1 400 ? -7.750  -33.877 -22.925 1.00 36.51  ? 663  ASP A C   1 
ATOM   2844 O  O   . ASP A 1 400 ? -6.547  -33.787 -22.899 1.00 33.65  ? 663  ASP A O   1 
ATOM   2845 C  CB  . ASP A 1 400 ? -8.284  -32.476 -20.877 1.00 44.15  ? 663  ASP A CB  1 
ATOM   2846 C  CG  . ASP A 1 400 ? -8.534  -33.658 -19.969 1.00 43.86  ? 663  ASP A CG  1 
ATOM   2847 O  OD1 . ASP A 1 400 ? -9.264  -34.556 -20.352 1.00 43.53  ? 663  ASP A OD1 1 
ATOM   2848 O  OD2 . ASP A 1 400 ? -7.974  -33.658 -18.885 1.00 57.74  ? 663  ASP A OD2 1 
ATOM   2849 N  N   . ASP A 1 401 ? -8.381  -34.893 -23.496 1.00 33.81  ? 664  ASP A N   1 
ATOM   2850 C  CA  . ASP A 1 401 ? -7.667  -36.107 -23.929 1.00 30.20  ? 664  ASP A CA  1 
ATOM   2851 C  C   . ASP A 1 401 ? -7.458  -36.064 -25.428 1.00 32.03  ? 664  ASP A C   1 
ATOM   2852 O  O   . ASP A 1 401 ? -8.426  -35.749 -26.108 1.00 29.72  ? 664  ASP A O   1 
ATOM   2853 C  CB  . ASP A 1 401 ? -8.449  -37.379 -23.637 1.00 33.84  ? 664  ASP A CB  1 
ATOM   2854 C  CG  . ASP A 1 401 ? -7.494  -38.531 -23.470 1.00 35.42  ? 664  ASP A CG  1 
ATOM   2855 O  OD1 . ASP A 1 401 ? -6.303  -38.240 -23.449 1.00 39.16  ? 664  ASP A OD1 1 
ATOM   2856 O  OD2 . ASP A 1 401 ? -7.932  -39.670 -23.407 1.00 35.83  ? 664  ASP A OD2 1 
ATOM   2857 N  N   . CYS A 1 402 ? -6.257  -36.396 -25.919 1.00 28.74  ? 665  CYS A N   1 
ATOM   2858 C  CA  . CYS A 1 402 ? -5.964  -36.386 -27.370 1.00 30.45  ? 665  CYS A CA  1 
ATOM   2859 C  C   . CYS A 1 402 ? -5.053  -37.527 -27.819 1.00 31.77  ? 665  CYS A C   1 
ATOM   2860 O  O   . CYS A 1 402 ? -4.224  -38.037 -27.019 1.00 32.70  ? 665  CYS A O   1 
ATOM   2861 C  CB  . CYS A 1 402 ? -5.350  -35.062 -27.810 1.00 36.97  ? 665  CYS A CB  1 
ATOM   2862 S  SG  . CYS A 1 402 ? -3.704  -34.731 -27.128 1.00 39.58  ? 665  CYS A SG  1 
ATOM   2863 N  N   . VAL A 1 403 ? -5.171  -37.812 -29.119 1.00 31.61  ? 666  VAL A N   1 
ATOM   2864 C  CA  . VAL A 1 403 ? -4.251  -38.658 -29.932 1.00 31.58  ? 666  VAL A CA  1 
ATOM   2865 C  C   . VAL A 1 403 ? -4.010  -37.866 -31.221 1.00 32.02  ? 666  VAL A C   1 
ATOM   2866 O  O   . VAL A 1 403 ? -4.994  -37.456 -31.851 1.00 31.97  ? 666  VAL A O   1 
ATOM   2867 C  CB  . VAL A 1 403 ? -4.860  -40.050 -30.193 1.00 31.69  ? 666  VAL A CB  1 
ATOM   2868 C  CG1 . VAL A 1 403 ? -4.044  -40.897 -31.153 1.00 30.78  ? 666  VAL A CG1 1 
ATOM   2869 C  CG2 . VAL A 1 403 ? -5.111  -40.804 -28.881 1.00 32.25  ? 666  VAL A CG2 1 
ATOM   2870 N  N   . VAL A 1 404 ? -2.758  -37.600 -31.571 1.00 28.98  ? 667  VAL A N   1 
ATOM   2871 C  CA  . VAL A 1 404 ? -2.354  -36.860 -32.813 1.00 29.72  ? 667  VAL A CA  1 
ATOM   2872 C  C   . VAL A 1 404 ? -1.428  -37.753 -33.604 1.00 28.73  ? 667  VAL A C   1 
ATOM   2873 O  O   . VAL A 1 404 ? -0.442  -38.256 -33.005 1.00 32.49  ? 667  VAL A O   1 
ATOM   2874 C  CB  . VAL A 1 404 ? -1.639  -35.536 -32.498 1.00 31.06  ? 667  VAL A CB  1 
ATOM   2875 C  CG1 . VAL A 1 404 ? -1.352  -34.728 -33.758 1.00 30.66  ? 667  VAL A CG1 1 
ATOM   2876 C  CG2 . VAL A 1 404 ? -2.442  -34.713 -31.507 1.00 33.53  ? 667  VAL A CG2 1 
ATOM   2877 N  N   . LYS A 1 405 ? -1.738  -37.961 -34.877 1.00 28.75  ? 668  LYS A N   1 
ATOM   2878 C  CA  . LYS A 1 405 ? -0.794  -38.530 -35.859 1.00 30.83  ? 668  LYS A CA  1 
ATOM   2879 C  C   . LYS A 1 405 ? -0.279  -37.390 -36.739 1.00 34.79  ? 668  LYS A C   1 
ATOM   2880 O  O   . LYS A 1 405 ? -0.838  -37.129 -37.800 1.00 31.01  ? 668  LYS A O   1 
ATOM   2881 C  CB  . LYS A 1 405 ? -1.371  -39.629 -36.746 1.00 34.47  ? 668  LYS A CB  1 
ATOM   2882 C  CG  . LYS A 1 405 ? -0.256  -40.289 -37.551 1.00 38.36  ? 668  LYS A CG  1 
ATOM   2883 C  CD  . LYS A 1 405 ? -0.577  -41.586 -38.251 1.00 42.55  ? 668  LYS A CD  1 
ATOM   2884 C  CE  . LYS A 1 405 ? 0.707   -42.232 -38.747 1.00 42.94  ? 668  LYS A CE  1 
ATOM   2885 N  NZ  . LYS A 1 405 ? 0.421   -43.367 -39.640 1.00 47.05  ? 668  LYS A NZ  1 
ATOM   2886 N  N   . PRO A 1 406 ? 0.831   -36.714 -36.362 1.00 35.06  ? 669  PRO A N   1 
ATOM   2887 C  CA  . PRO A 1 406 ? 1.336   -35.605 -37.164 1.00 35.88  ? 669  PRO A CA  1 
ATOM   2888 C  C   . PRO A 1 406 ? 1.990   -36.049 -38.484 1.00 33.73  ? 669  PRO A C   1 
ATOM   2889 O  O   . PRO A 1 406 ? 2.170   -37.244 -38.747 1.00 33.68  ? 669  PRO A O   1 
ATOM   2890 C  CB  . PRO A 1 406 ? 2.341   -34.963 -36.214 1.00 36.76  ? 669  PRO A CB  1 
ATOM   2891 C  CG  . PRO A 1 406 ? 2.897   -36.158 -35.477 1.00 38.31  ? 669  PRO A CG  1 
ATOM   2892 C  CD  . PRO A 1 406 ? 1.669   -36.988 -35.191 1.00 35.15  ? 669  PRO A CD  1 
ATOM   2893 N  N   . LEU A 1 407 ? 2.288   -35.063 -39.321 1.00 36.49  ? 670  LEU A N   1 
ATOM   2894 C  CA  . LEU A 1 407 ? 2.943   -35.249 -40.644 1.00 39.38  ? 670  LEU A CA  1 
ATOM   2895 C  C   . LEU A 1 407 ? 4.270   -36.021 -40.477 1.00 39.67  ? 670  LEU A C   1 
ATOM   2896 O  O   . LEU A 1 407 ? 4.595   -36.860 -41.356 1.00 38.08  ? 670  LEU A O   1 
ATOM   2897 C  CB  . LEU A 1 407 ? 3.142   -33.854 -41.237 1.00 40.97  ? 670  LEU A CB  1 
ATOM   2898 C  CG  . LEU A 1 407 ? 3.109   -33.785 -42.752 1.00 47.94  ? 670  LEU A CG  1 
ATOM   2899 C  CD1 . LEU A 1 407 ? 1.773   -34.259 -43.293 1.00 49.61  ? 670  LEU A CD1 1 
ATOM   2900 C  CD2 . LEU A 1 407 ? 3.398   -32.367 -43.200 1.00 55.04  ? 670  LEU A CD2 1 
ATOM   2901 N  N   . ASP A 1 408 ? 4.976   -35.822 -39.357 1.00 39.39  ? 671  ASP A N   1 
ATOM   2902 C  CA  . ASP A 1 408 ? 6.260   -36.534 -39.085 1.00 39.63  ? 671  ASP A CA  1 
ATOM   2903 C  C   . ASP A 1 408 ? 6.651   -36.336 -37.624 1.00 37.29  ? 671  ASP A C   1 
ATOM   2904 O  O   . ASP A 1 408 ? 5.927   -35.654 -36.918 1.00 38.95  ? 671  ASP A O   1 
ATOM   2905 C  CB  . ASP A 1 408 ? 7.348   -36.025 -40.049 1.00 44.20  ? 671  ASP A CB  1 
ATOM   2906 C  CG  . ASP A 1 408 ? 7.405   -34.518 -40.048 1.00 40.85  ? 671  ASP A CG  1 
ATOM   2907 O  OD1 . ASP A 1 408 ? 7.778   -33.968 -38.967 1.00 41.14  ? 671  ASP A OD1 1 
ATOM   2908 O  OD2 . ASP A 1 408 ? 7.020   -33.903 -41.097 1.00 40.88  ? 671  ASP A OD2 1 
ATOM   2909 N  N   . ASP A 1 409 ? 7.797   -36.862 -37.204 1.00 38.68  ? 672  ASP A N   1 
ATOM   2910 C  CA  . ASP A 1 409 ? 8.183   -36.883 -35.769 1.00 37.82  ? 672  ASP A CA  1 
ATOM   2911 C  C   . ASP A 1 409 ? 8.851   -35.575 -35.314 1.00 33.76  ? 672  ASP A C   1 
ATOM   2912 O  O   . ASP A 1 409 ? 9.134   -35.478 -34.114 1.00 36.27  ? 672  ASP A O   1 
ATOM   2913 C  CB  . ASP A 1 409 ? 8.918   -38.185 -35.472 1.00 40.98  ? 672  ASP A CB  1 
ATOM   2914 C  CG  . ASP A 1 409 ? 7.980   -39.370 -35.660 1.00 43.78  ? 672  ASP A CG  1 
ATOM   2915 O  OD1 . ASP A 1 409 ? 6.845   -39.326 -35.109 1.00 41.04  ? 672  ASP A OD1 1 
ATOM   2916 O  OD2 . ASP A 1 409 ? 8.363   -40.292 -36.388 1.00 46.65  ? 672  ASP A OD2 1 
ATOM   2917 N  N   . ARG A 1 410 ? 8.919   -34.522 -36.134 1.00 35.26  ? 673  ARG A N   1 
ATOM   2918 C  CA  . ARG A 1 410 ? 9.344   -33.189 -35.603 1.00 35.72  ? 673  ARG A CA  1 
ATOM   2919 C  C   . ARG A 1 410 ? 8.388   -32.726 -34.504 1.00 35.73  ? 673  ARG A C   1 
ATOM   2920 O  O   . ARG A 1 410 ? 8.821   -31.982 -33.620 1.00 37.70  ? 673  ARG A O   1 
ATOM   2921 C  CB  . ARG A 1 410 ? 9.384   -32.111 -36.694 1.00 42.96  ? 673  ARG A CB  1 
ATOM   2922 C  CG  . ARG A 1 410 ? 10.463  -32.289 -37.757 1.00 43.75  ? 673  ARG A CG  1 
ATOM   2923 C  CD  . ARG A 1 410 ? 10.279  -31.244 -38.841 1.00 43.04  ? 673  ARG A CD  1 
ATOM   2924 N  NE  . ARG A 1 410 ? 9.125   -31.561 -39.687 1.00 45.21  ? 673  ARG A NE  1 
ATOM   2925 C  CZ  . ARG A 1 410 ? 8.627   -30.795 -40.668 1.00 49.26  ? 673  ARG A CZ  1 
ATOM   2926 N  NH1 . ARG A 1 410 ? 9.179   -29.627 -40.961 1.00 45.95  ? 673  ARG A NH1 1 
ATOM   2927 N  NH2 . ARG A 1 410 ? 7.582   -31.217 -41.372 1.00 47.02  ? 673  ARG A NH2 1 
ATOM   2928 N  N   . PHE A 1 411 ? 7.090   -33.073 -34.591 1.00 36.78  ? 674  PHE A N   1 
ATOM   2929 C  CA  . PHE A 1 411 ? 6.056   -32.781 -33.566 1.00 32.16  ? 674  PHE A CA  1 
ATOM   2930 C  C   . PHE A 1 411 ? 6.577   -33.131 -32.169 1.00 29.70  ? 674  PHE A C   1 
ATOM   2931 O  O   . PHE A 1 411 ? 6.294   -32.361 -31.233 1.00 32.79  ? 674  PHE A O   1 
ATOM   2932 C  CB  . PHE A 1 411 ? 4.796   -33.617 -33.872 1.00 38.24  ? 674  PHE A CB  1 
ATOM   2933 C  CG  . PHE A 1 411 ? 3.599   -33.397 -32.990 1.00 33.78  ? 674  PHE A CG  1 
ATOM   2934 C  CD1 . PHE A 1 411 ? 3.394   -34.178 -31.863 1.00 36.75  ? 674  PHE A CD1 1 
ATOM   2935 C  CD2 . PHE A 1 411 ? 2.617   -32.496 -33.352 1.00 34.46  ? 674  PHE A CD2 1 
ATOM   2936 C  CE1 . PHE A 1 411 ? 2.250   -34.015 -31.091 1.00 33.81  ? 674  PHE A CE1 1 
ATOM   2937 C  CE2 . PHE A 1 411 ? 1.469   -32.339 -32.586 1.00 33.44  ? 674  PHE A CE2 1 
ATOM   2938 C  CZ  . PHE A 1 411 ? 1.284   -33.099 -31.450 1.00 30.29  ? 674  PHE A CZ  1 
ATOM   2939 N  N   . ALA A 1 412 ? 7.311   -34.246 -32.013 1.00 32.42  ? 675  ALA A N   1 
ATOM   2940 C  CA  . ALA A 1 412 ? 7.761   -34.775 -30.695 1.00 30.97  ? 675  ALA A CA  1 
ATOM   2941 C  C   . ALA A 1 412 ? 8.551   -33.734 -29.877 1.00 34.31  ? 675  ALA A C   1 
ATOM   2942 O  O   . ALA A 1 412 ? 8.393   -33.680 -28.630 1.00 33.54  ? 675  ALA A O   1 
ATOM   2943 C  CB  . ALA A 1 412 ? 8.539   -36.045 -30.907 1.00 31.56  ? 675  ALA A CB  1 
ATOM   2944 N  N   . SER A 1 413 ? 9.323   -32.863 -30.528 1.00 36.79  ? 676  SER A N   1 
ATOM   2945 C  CA  . SER A 1 413 ? 10.141  -31.833 -29.832 1.00 41.93  ? 676  SER A CA  1 
ATOM   2946 C  C   . SER A 1 413 ? 9.636   -30.413 -30.108 1.00 45.12  ? 676  SER A C   1 
ATOM   2947 O  O   . SER A 1 413 ? 10.310  -29.474 -29.662 1.00 45.43  ? 676  SER A O   1 
ATOM   2948 C  CB  . SER A 1 413 ? 11.624  -31.990 -30.150 1.00 42.48  ? 676  SER A CB  1 
ATOM   2949 O  OG  . SER A 1 413 ? 11.818  -32.405 -31.487 1.00 48.60  ? 676  SER A OG  1 
ATOM   2950 N  N   . ALA A 1 414 ? 8.454   -30.251 -30.718 1.00 43.47  ? 677  ALA A N   1 
ATOM   2951 C  CA  . ALA A 1 414 ? 7.787   -28.937 -30.902 1.00 40.23  ? 677  ALA A CA  1 
ATOM   2952 C  C   . ALA A 1 414 ? 7.057   -28.594 -29.609 1.00 43.54  ? 677  ALA A C   1 
ATOM   2953 O  O   . ALA A 1 414 ? 5.842   -28.970 -29.500 1.00 45.95  ? 677  ALA A O   1 
ATOM   2954 C  CB  . ALA A 1 414 ? 6.825   -29.000 -32.064 1.00 41.71  ? 677  ALA A CB  1 
ATOM   2955 N  N   . LEU A 1 415 ? 7.734   -27.959 -28.658 1.00 37.04  ? 678  LEU A N   1 
ATOM   2956 C  CA  . LEU A 1 415 ? 7.220   -27.828 -27.275 1.00 39.58  ? 678  LEU A CA  1 
ATOM   2957 C  C   . LEU A 1 415 ? 7.055   -26.375 -26.837 1.00 38.87  ? 678  LEU A C   1 
ATOM   2958 O  O   . LEU A 1 415 ? 6.460   -26.178 -25.752 1.00 43.62  ? 678  LEU A O   1 
ATOM   2959 C  CB  . LEU A 1 415 ? 8.147   -28.566 -26.319 1.00 40.28  ? 678  LEU A CB  1 
ATOM   2960 C  CG  . LEU A 1 415 ? 8.280   -30.073 -26.554 1.00 42.30  ? 678  LEU A CG  1 
ATOM   2961 C  CD1 . LEU A 1 415 ? 9.381   -30.663 -25.671 1.00 38.36  ? 678  LEU A CD1 1 
ATOM   2962 C  CD2 . LEU A 1 415 ? 6.970   -30.785 -26.291 1.00 43.05  ? 678  LEU A CD2 1 
ATOM   2963 N  N   . THR A 1 416 ? 7.479   -25.388 -27.626 1.00 40.19  ? 679  THR A N   1 
ATOM   2964 C  CA  . THR A 1 416 ? 7.586   -23.997 -27.093 1.00 41.74  ? 679  THR A CA  1 
ATOM   2965 C  C   . THR A 1 416 ? 6.178   -23.416 -26.984 1.00 39.19  ? 679  THR A C   1 
ATOM   2966 O  O   . THR A 1 416 ? 5.854   -22.880 -25.896 1.00 37.43  ? 679  THR A O   1 
ATOM   2967 C  CB  . THR A 1 416 ? 8.541   -23.093 -27.886 1.00 45.19  ? 679  THR A CB  1 
ATOM   2968 O  OG1 . THR A 1 416 ? 8.045   -22.867 -29.200 1.00 48.23  ? 679  THR A OG1 1 
ATOM   2969 C  CG2 . THR A 1 416 ? 9.924   -23.692 -28.025 1.00 50.07  ? 679  THR A CG2 1 
ATOM   2970 N  N   . ALA A 1 417 ? 5.369   -23.532 -28.041 1.00 38.63  ? 680  ALA A N   1 
ATOM   2971 C  CA  . ALA A 1 417 ? 3.971   -23.024 -28.033 1.00 36.44  ? 680  ALA A CA  1 
ATOM   2972 C  C   . ALA A 1 417 ? 3.145   -23.783 -26.982 1.00 37.62  ? 680  ALA A C   1 
ATOM   2973 O  O   . ALA A 1 417 ? 2.416   -23.121 -26.175 1.00 40.02  ? 680  ALA A O   1 
ATOM   2974 C  CB  . ALA A 1 417 ? 3.407   -23.076 -29.424 1.00 39.90  ? 680  ALA A CB  1 
ATOM   2975 N  N   . LEU A 1 418 ? 3.277   -25.113 -26.912 1.00 37.52  ? 681  LEU A N   1 
ATOM   2976 C  CA  . LEU A 1 418 ? 2.459   -25.932 -25.971 1.00 36.76  ? 681  LEU A CA  1 
ATOM   2977 C  C   . LEU A 1 418 ? 2.767   -25.557 -24.527 1.00 40.18  ? 681  LEU A C   1 
ATOM   2978 O  O   . LEU A 1 418 ? 1.830   -25.456 -23.706 1.00 42.57  ? 681  LEU A O   1 
ATOM   2979 C  CB  . LEU A 1 418 ? 2.779   -27.400 -26.211 1.00 41.84  ? 681  LEU A CB  1 
ATOM   2980 C  CG  . LEU A 1 418 ? 1.969   -28.391 -25.391 1.00 45.66  ? 681  LEU A CG  1 
ATOM   2981 C  CD1 . LEU A 1 418 ? 0.544   -28.478 -25.923 1.00 43.06  ? 681  LEU A CD1 1 
ATOM   2982 C  CD2 . LEU A 1 418 ? 2.665   -29.742 -25.423 1.00 42.40  ? 681  LEU A CD2 1 
ATOM   2983 N  N   . ASN A 1 419 ? 4.054   -25.435 -24.192 1.00 45.30  ? 682  ASN A N   1 
ATOM   2984 C  CA  . ASN A 1 419 ? 4.479   -25.075 -22.819 1.00 42.82  ? 682  ASN A CA  1 
ATOM   2985 C  C   . ASN A 1 419 ? 4.036   -23.628 -22.543 1.00 42.05  ? 682  ASN A C   1 
ATOM   2986 O  O   . ASN A 1 419 ? 3.538   -23.380 -21.437 1.00 42.72  ? 682  ASN A O   1 
ATOM   2987 C  CB  . ASN A 1 419 ? 5.990   -25.251 -22.652 1.00 47.56  ? 682  ASN A CB  1 
ATOM   2988 C  CG  . ASN A 1 419 ? 6.446   -26.683 -22.434 1.00 45.29  ? 682  ASN A CG  1 
ATOM   2989 O  OD1 . ASN A 1 419 ? 5.777   -27.480 -21.764 1.00 43.85  ? 682  ASN A OD1 1 
ATOM   2990 N  ND2 . ASN A 1 419 ? 7.602   -27.011 -22.984 1.00 40.45  ? 682  ASN A ND2 1 
ATOM   2991 N  N   . ASP A 1 420 ? 4.199   -22.707 -23.501 1.00 39.43  ? 683  ASP A N   1 
ATOM   2992 C  CA  . ASP A 1 420 ? 3.874   -21.261 -23.319 1.00 47.93  ? 683  ASP A CA  1 
ATOM   2993 C  C   . ASP A 1 420 ? 2.352   -21.023 -23.229 1.00 45.66  ? 683  ASP A C   1 
ATOM   2994 O  O   . ASP A 1 420 ? 1.956   -20.149 -22.450 1.00 45.21  ? 683  ASP A O   1 
ATOM   2995 C  CB  . ASP A 1 420 ? 4.452   -20.367 -24.426 1.00 51.41  ? 683  ASP A CB  1 
ATOM   2996 C  CG  . ASP A 1 420 ? 4.337   -18.876 -24.099 1.00 54.37  ? 683  ASP A CG  1 
ATOM   2997 O  OD1 . ASP A 1 420 ? 4.650   -18.497 -22.925 1.00 46.62  ? 683  ASP A OD1 1 
ATOM   2998 O  OD2 . ASP A 1 420 ? 3.887   -18.103 -24.995 1.00 50.84  ? 683  ASP A OD2 1 
ATOM   2999 N  N   . MET A 1 421 ? 1.514   -21.819 -23.910 1.00 46.02  ? 684  MET A N   1 
ATOM   3000 C  CA  . MET A 1 421 ? 0.033   -21.792 -23.707 1.00 41.30  ? 684  MET A CA  1 
ATOM   3001 C  C   . MET A 1 421 ? -0.316  -22.328 -22.315 1.00 42.63  ? 684  MET A C   1 
ATOM   3002 O  O   . MET A 1 421 ? -1.487  -22.252 -21.949 1.00 46.71  ? 684  MET A O   1 
ATOM   3003 C  CB  . MET A 1 421 ? -0.700  -22.619 -24.770 1.00 45.63  ? 684  MET A CB  1 
ATOM   3004 C  CG  . MET A 1 421 ? -0.573  -22.034 -26.162 1.00 43.86  ? 684  MET A CG  1 
ATOM   3005 S  SD  . MET A 1 421 ? -1.415  -23.000 -27.444 1.00 48.87  ? 684  MET A SD  1 
ATOM   3006 C  CE  . MET A 1 421 ? -0.491  -24.532 -27.485 1.00 54.50  ? 684  MET A CE  1 
ATOM   3007 N  N   . GLY A 1 422 ? 0.634   -22.924 -21.589 1.00 42.25  ? 685  GLY A N   1 
ATOM   3008 C  CA  . GLY A 1 422 ? 0.419   -23.473 -20.228 1.00 37.68  ? 685  GLY A CA  1 
ATOM   3009 C  C   . GLY A 1 422 ? -0.100  -24.900 -20.214 1.00 38.11  ? 685  GLY A C   1 
ATOM   3010 O  O   . GLY A 1 422 ? -0.372  -25.395 -19.111 1.00 38.15  ? 685  GLY A O   1 
ATOM   3011 N  N   . LYS A 1 423 ? -0.170  -25.571 -21.364 1.00 36.74  ? 686  LYS A N   1 
ATOM   3012 C  CA  . LYS A 1 423 ? -0.627  -26.991 -21.473 1.00 40.53  ? 686  LYS A CA  1 
ATOM   3013 C  C   . LYS A 1 423 ? 0.579   -27.940 -21.266 1.00 43.16  ? 686  LYS A C   1 
ATOM   3014 O  O   . LYS A 1 423 ? 0.940   -28.725 -22.168 1.00 41.79  ? 686  LYS A O   1 
ATOM   3015 C  CB  . LYS A 1 423 ? -1.378  -27.151 -22.797 1.00 38.65  ? 686  LYS A CB  1 
ATOM   3016 C  CG  . LYS A 1 423 ? -2.509  -26.143 -22.974 1.00 38.27  ? 686  LYS A CG  1 
ATOM   3017 C  CD  . LYS A 1 423 ? -3.453  -26.142 -21.742 1.00 45.35  ? 686  LYS A CD  1 
ATOM   3018 C  CE  . LYS A 1 423 ? -4.638  -25.193 -21.814 1.00 47.78  ? 686  LYS A CE  1 
ATOM   3019 N  NZ  . LYS A 1 423 ? -4.217  -23.789 -22.028 1.00 49.88  ? 686  LYS A NZ  1 
ATOM   3020 N  N   . VAL A 1 424 ? 1.134   -27.897 -20.062 1.00 46.00  ? 687  VAL A N   1 
ATOM   3021 C  CA  . VAL A 1 424 ? 2.369   -28.627 -19.647 1.00 48.47  ? 687  VAL A CA  1 
ATOM   3022 C  C   . VAL A 1 424 ? 2.042   -30.118 -19.591 1.00 41.13  ? 687  VAL A C   1 
ATOM   3023 O  O   . VAL A 1 424 ? 1.004   -30.460 -18.964 1.00 44.79  ? 687  VAL A O   1 
ATOM   3024 C  CB  . VAL A 1 424 ? 2.866   -28.074 -18.293 1.00 54.51  ? 687  VAL A CB  1 
ATOM   3025 C  CG1 . VAL A 1 424 ? 3.827   -29.012 -17.575 1.00 59.92  ? 687  VAL A CG1 1 
ATOM   3026 C  CG2 . VAL A 1 424 ? 3.499   -26.708 -18.496 1.00 53.21  ? 687  VAL A CG2 1 
ATOM   3027 N  N   . ARG A 1 425 ? 2.873   -30.958 -20.232 1.00 37.52  ? 688  ARG A N   1 
ATOM   3028 C  CA  . ARG A 1 425 ? 2.660   -32.427 -20.308 1.00 38.42  ? 688  ARG A CA  1 
ATOM   3029 C  C   . ARG A 1 425 ? 2.834   -33.023 -18.905 1.00 41.05  ? 688  ARG A C   1 
ATOM   3030 O  O   . ARG A 1 425 ? 3.706   -32.492 -18.166 1.00 52.51  ? 688  ARG A O   1 
ATOM   3031 C  CB  . ARG A 1 425 ? 3.594   -33.084 -21.324 1.00 36.70  ? 688  ARG A CB  1 
ATOM   3032 C  CG  . ARG A 1 425 ? 3.300   -32.683 -22.754 1.00 38.92  ? 688  ARG A CG  1 
ATOM   3033 C  CD  . ARG A 1 425 ? 4.423   -32.983 -23.718 1.00 41.61  ? 688  ARG A CD  1 
ATOM   3034 N  NE  . ARG A 1 425 ? 5.681   -32.382 -23.267 1.00 43.90  ? 688  ARG A NE  1 
ATOM   3035 C  CZ  . ARG A 1 425 ? 6.911   -32.817 -23.558 1.00 43.35  ? 688  ARG A CZ  1 
ATOM   3036 N  NH1 . ARG A 1 425 ? 7.111   -33.841 -24.377 1.00 40.86  ? 688  ARG A NH1 1 
ATOM   3037 N  NH2 . ARG A 1 425 ? 7.949   -32.168 -23.049 1.00 43.31  ? 688  ARG A NH2 1 
ATOM   3038 N  N   . LYS A 1 426 ? 2.033   -34.050 -18.564 1.00 40.95  ? 689  LYS A N   1 
ATOM   3039 C  CA  . LYS A 1 426 ? 2.096   -34.866 -17.308 1.00 46.14  ? 689  LYS A CA  1 
ATOM   3040 C  C   . LYS A 1 426 ? 3.293   -35.861 -17.369 1.00 54.79  ? 689  LYS A C   1 
ATOM   3041 O  O   . LYS A 1 426 ? 3.543   -36.449 -18.455 1.00 50.83  ? 689  LYS A O   1 
ATOM   3042 C  CB  . LYS A 1 426 ? 0.763   -35.604 -17.119 1.00 52.00  ? 689  LYS A CB  1 
ATOM   3043 C  CG  . LYS A 1 426 ? 0.448   -36.067 -15.698 1.00 57.53  ? 689  LYS A CG  1 
ATOM   3044 C  CD  . LYS A 1 426 ? -0.839  -36.860 -15.558 1.00 62.54  ? 689  LYS A CD  1 
ATOM   3045 C  CE  . LYS A 1 426 ? -0.954  -37.929 -16.629 1.00 81.67  ? 689  LYS A CE  1 
ATOM   3046 N  NZ  . LYS A 1 426 ? -1.924  -39.007 -16.307 1.00 90.15  ? 689  LYS A NZ  1 
ATOM   3047 N  N   . ASP A 1 427 ? 4.052   -36.018 -16.271 1.00 53.21  ? 690  ASP A N   1 
ATOM   3048 C  CA  . ASP A 1 427 ? 5.050   -37.113 -16.070 1.00 58.87  ? 690  ASP A CA  1 
ATOM   3049 C  C   . ASP A 1 427 ? 6.121   -37.176 -17.181 1.00 58.69  ? 690  ASP A C   1 
ATOM   3050 O  O   . ASP A 1 427 ? 6.376   -38.282 -17.699 1.00 58.92  ? 690  ASP A O   1 
ATOM   3051 C  CB  . ASP A 1 427 ? 4.324   -38.452 -15.995 1.00 58.62  ? 690  ASP A CB  1 
ATOM   3052 C  CG  . ASP A 1 427 ? 3.470   -38.573 -14.757 1.00 67.87  ? 690  ASP A CG  1 
ATOM   3053 O  OD1 . ASP A 1 427 ? 3.681   -37.767 -13.810 1.00 70.36  ? 690  ASP A OD1 1 
ATOM   3054 O  OD2 . ASP A 1 427 ? 2.592   -39.454 -14.768 1.00 79.25  ? 690  ASP A OD2 1 
ATOM   3055 N  N   . ILE A 1 428 ? 6.710   -36.039 -17.551 1.00 52.42  ? 691  ILE A N   1 
ATOM   3056 C  CA  . ILE A 1 428 ? 7.851   -35.936 -18.506 1.00 51.36  ? 691  ILE A CA  1 
ATOM   3057 C  C   . ILE A 1 428 ? 8.420   -34.542 -18.322 1.00 52.07  ? 691  ILE A C   1 
ATOM   3058 O  O   . ILE A 1 428 ? 7.635   -33.640 -18.017 1.00 56.18  ? 691  ILE A O   1 
ATOM   3059 C  CB  . ILE A 1 428 ? 7.423   -36.209 -19.962 1.00 56.00  ? 691  ILE A CB  1 
ATOM   3060 C  CG1 . ILE A 1 428 ? 8.635   -36.266 -20.894 1.00 54.75  ? 691  ILE A CG1 1 
ATOM   3061 C  CG2 . ILE A 1 428 ? 6.391   -35.205 -20.454 1.00 54.34  ? 691  ILE A CG2 1 
ATOM   3062 C  CD1 . ILE A 1 428 ? 8.367   -36.971 -22.191 1.00 55.65  ? 691  ILE A CD1 1 
ATOM   3063 N  N   . GLN A 1 429 ? 9.731   -34.377 -18.395 1.00 56.79  ? 692  GLN A N   1 
ATOM   3064 C  CA  . GLN A 1 429 ? 10.380  -33.064 -18.130 1.00 60.85  ? 692  GLN A CA  1 
ATOM   3065 C  C   . GLN A 1 429 ? 9.984   -32.080 -19.241 1.00 51.91  ? 692  GLN A C   1 
ATOM   3066 O  O   . GLN A 1 429 ? 9.906   -32.448 -20.448 1.00 47.19  ? 692  GLN A O   1 
ATOM   3067 C  CB  . GLN A 1 429 ? 11.900  -33.210 -17.988 1.00 75.64  ? 692  GLN A CB  1 
ATOM   3068 C  CG  . GLN A 1 429 ? 12.334  -34.161 -16.868 1.00 91.84  ? 692  GLN A CG  1 
ATOM   3069 C  CD  . GLN A 1 429 ? 13.730  -34.724 -17.045 1.00 109.14 ? 692  GLN A CD  1 
ATOM   3070 O  OE1 . GLN A 1 429 ? 14.124  -35.164 -18.132 1.00 111.79 ? 692  GLN A OE1 1 
ATOM   3071 N  NE2 . GLN A 1 429 ? 14.495  -34.731 -15.961 1.00 113.53 ? 692  GLN A NE2 1 
ATOM   3072 N  N   . GLN A 1 430 ? 9.803   -30.842 -18.839 1.00 54.86  ? 693  GLN A N   1 
ATOM   3073 C  CA  . GLN A 1 430 ? 9.167   -29.796 -19.658 1.00 60.06  ? 693  GLN A CA  1 
ATOM   3074 C  C   . GLN A 1 430 ? 9.744   -29.814 -21.072 1.00 54.97  ? 693  GLN A C   1 
ATOM   3075 O  O   . GLN A 1 430 ? 8.942   -29.574 -22.006 1.00 51.29  ? 693  GLN A O   1 
ATOM   3076 C  CB  . GLN A 1 430 ? 9.316   -28.418 -19.014 1.00 65.03  ? 693  GLN A CB  1 
ATOM   3077 C  CG  . GLN A 1 430 ? 8.125   -27.543 -19.344 1.00 73.75  ? 693  GLN A CG  1 
ATOM   3078 C  CD  . GLN A 1 430 ? 8.258   -26.100 -18.925 1.00 78.39  ? 693  GLN A CD  1 
ATOM   3079 O  OE1 . GLN A 1 430 ? 7.323   -25.495 -18.398 1.00 68.37  ? 693  GLN A OE1 1 
ATOM   3080 N  NE2 . GLN A 1 430 ? 9.412   -25.522 -19.200 1.00 79.52  ? 693  GLN A NE2 1 
ATOM   3081 N  N   . TRP A 1 431 ? 11.052  -30.059 -21.239 1.00 48.54  ? 694  TRP A N   1 
ATOM   3082 C  CA  . TRP A 1 431 ? 11.743  -29.858 -22.552 1.00 47.80  ? 694  TRP A CA  1 
ATOM   3083 C  C   . TRP A 1 431 ? 12.214  -31.186 -23.161 1.00 46.77  ? 694  TRP A C   1 
ATOM   3084 O  O   . TRP A 1 431 ? 12.864  -31.143 -24.211 1.00 49.11  ? 694  TRP A O   1 
ATOM   3085 C  CB  . TRP A 1 431 ? 12.863  -28.819 -22.427 1.00 54.67  ? 694  TRP A CB  1 
ATOM   3086 C  CG  . TRP A 1 431 ? 12.333  -27.470 -22.026 1.00 63.01  ? 694  TRP A CG  1 
ATOM   3087 C  CD1 . TRP A 1 431 ? 12.481  -26.859 -20.819 1.00 55.10  ? 694  TRP A CD1 1 
ATOM   3088 C  CD2 . TRP A 1 431 ? 11.478  -26.607 -22.810 1.00 59.95  ? 694  TRP A CD2 1 
ATOM   3089 N  NE1 . TRP A 1 431 ? 11.827  -25.655 -20.818 1.00 62.50  ? 694  TRP A NE1 1 
ATOM   3090 C  CE2 . TRP A 1 431 ? 11.193  -25.477 -22.017 1.00 59.63  ? 694  TRP A CE2 1 
ATOM   3091 C  CE3 . TRP A 1 431 ? 10.949  -26.670 -24.108 1.00 57.30  ? 694  TRP A CE3 1 
ATOM   3092 C  CZ2 . TRP A 1 431 ? 10.366  -24.444 -22.459 1.00 57.33  ? 694  TRP A CZ2 1 
ATOM   3093 C  CZ3 . TRP A 1 431 ? 10.162  -25.632 -24.563 1.00 59.83  ? 694  TRP A CZ3 1 
ATOM   3094 C  CH2 . TRP A 1 431 ? 9.867   -24.541 -23.741 1.00 58.88  ? 694  TRP A CH2 1 
ATOM   3095 N  N   . GLU A 1 432 ? 11.802  -32.309 -22.567 1.00 43.72  ? 695  GLU A N   1 
ATOM   3096 C  CA  . GLU A 1 432 ? 12.097  -33.685 -23.035 1.00 48.84  ? 695  GLU A CA  1 
ATOM   3097 C  C   . GLU A 1 432 ? 11.107  -34.032 -24.162 1.00 47.42  ? 695  GLU A C   1 
ATOM   3098 O  O   . GLU A 1 432 ? 9.905   -33.811 -24.042 1.00 42.24  ? 695  GLU A O   1 
ATOM   3099 C  CB  . GLU A 1 432 ? 12.067  -34.575 -21.784 1.00 52.08  ? 695  GLU A CB  1 
ATOM   3100 C  CG  . GLU A 1 432 ? 12.665  -35.951 -21.949 1.00 64.93  ? 695  GLU A CG  1 
ATOM   3101 C  CD  . GLU A 1 432 ? 14.158  -35.966 -22.268 1.00 80.02  ? 695  GLU A CD  1 
ATOM   3102 O  OE1 . GLU A 1 432 ? 14.576  -36.905 -23.005 1.00 83.88  ? 695  GLU A OE1 1 
ATOM   3103 O  OE2 . GLU A 1 432 ? 14.909  -35.035 -21.797 1.00 75.30  ? 695  GLU A OE2 1 
ATOM   3104 N  N   . PRO A 1 433 ? 11.562  -34.558 -25.313 1.00 43.75  ? 696  PRO A N   1 
ATOM   3105 C  CA  . PRO A 1 433 ? 10.662  -34.876 -26.417 1.00 40.71  ? 696  PRO A CA  1 
ATOM   3106 C  C   . PRO A 1 433 ? 9.655   -35.969 -26.082 1.00 43.01  ? 696  PRO A C   1 
ATOM   3107 O  O   . PRO A 1 433 ? 9.994   -36.869 -25.392 1.00 44.00  ? 696  PRO A O   1 
ATOM   3108 C  CB  . PRO A 1 433 ? 11.570  -35.365 -27.542 1.00 48.21  ? 696  PRO A CB  1 
ATOM   3109 C  CG  . PRO A 1 433 ? 12.956  -34.784 -27.149 1.00 49.22  ? 696  PRO A CG  1 
ATOM   3110 C  CD  . PRO A 1 433 ? 12.964  -34.864 -25.642 1.00 47.08  ? 696  PRO A CD  1 
ATOM   3111 N  N   . SER A 1 434 ? 8.428   -35.806 -26.581 1.00 39.80  ? 697  SER A N   1 
ATOM   3112 C  CA  . SER A 1 434 ? 7.323   -36.769 -26.441 1.00 38.21  ? 697  SER A CA  1 
ATOM   3113 C  C   . SER A 1 434 ? 7.760   -38.138 -26.965 1.00 37.43  ? 697  SER A C   1 
ATOM   3114 O  O   . SER A 1 434 ? 8.369   -38.209 -28.004 1.00 38.79  ? 697  SER A O   1 
ATOM   3115 C  CB  . SER A 1 434 ? 6.094   -36.277 -27.218 1.00 34.56  ? 697  SER A CB  1 
ATOM   3116 O  OG  . SER A 1 434 ? 5.520   -35.140 -26.618 1.00 33.34  ? 697  SER A OG  1 
ATOM   3117 N  N   . ARG A 1 435 ? 7.448   -39.189 -26.202 0.50 40.27  ? 698  ARG A N   1 
ATOM   3118 C  CA  . ARG A 1 435 ? 7.465   -40.611 -26.636 0.50 44.25  ? 698  ARG A CA  1 
ATOM   3119 C  C   . ARG A 1 435 ? 6.224   -40.857 -27.494 0.50 44.40  ? 698  ARG A C   1 
ATOM   3120 O  O   . ARG A 1 435 ? 5.118   -40.674 -26.960 0.50 45.77  ? 698  ARG A O   1 
ATOM   3121 C  CB  . ARG A 1 435 ? 7.376   -41.572 -25.443 0.50 46.68  ? 698  ARG A CB  1 
ATOM   3122 C  CG  . ARG A 1 435 ? 8.451   -41.420 -24.376 0.50 50.29  ? 698  ARG A CG  1 
ATOM   3123 C  CD  . ARG A 1 435 ? 8.301   -42.531 -23.341 0.50 52.64  ? 698  ARG A CD  1 
ATOM   3124 N  NE  . ARG A 1 435 ? 9.328   -42.546 -22.305 0.50 54.79  ? 698  ARG A NE  1 
ATOM   3125 C  CZ  . ARG A 1 435 ? 9.236   -41.918 -21.133 0.50 57.16  ? 698  ARG A CZ  1 
ATOM   3126 N  NH1 . ARG A 1 435 ? 8.158   -41.208 -20.832 0.50 55.39  ? 698  ARG A NH1 1 
ATOM   3127 N  NH2 . ARG A 1 435 ? 10.228  -42.004 -20.265 0.50 55.67  ? 698  ARG A NH2 1 
ATOM   3128 N  N   . GLY A 1 436 ? 6.390   -41.246 -28.759 1.00 44.19  ? 699  GLY A N   1 
ATOM   3129 C  CA  . GLY A 1 436 ? 5.248   -41.598 -29.626 1.00 44.09  ? 699  GLY A CA  1 
ATOM   3130 C  C   . GLY A 1 436 ? 4.942   -43.088 -29.616 1.00 42.62  ? 699  GLY A C   1 
ATOM   3131 O  O   . GLY A 1 436 ? 5.743   -43.848 -29.153 1.00 40.83  ? 699  GLY A O   1 
ATOM   3132 N  N   . TRP A 1 437 ? 3.788   -43.500 -30.124 1.00 41.49  ? 700  TRP A N   1 
ATOM   3133 C  CA  . TRP A 1 437 ? 3.433   -44.929 -30.229 1.00 36.49  ? 700  TRP A CA  1 
ATOM   3134 C  C   . TRP A 1 437 ? 3.522   -45.294 -31.694 1.00 35.94  ? 700  TRP A C   1 
ATOM   3135 O  O   . TRP A 1 437 ? 3.106   -44.474 -32.527 1.00 35.15  ? 700  TRP A O   1 
ATOM   3136 C  CB  . TRP A 1 437 ? 2.039   -45.177 -29.678 1.00 36.82  ? 700  TRP A CB  1 
ATOM   3137 C  CG  . TRP A 1 437 ? 1.847   -44.686 -28.284 1.00 31.43  ? 700  TRP A CG  1 
ATOM   3138 C  CD1 . TRP A 1 437 ? 1.508   -43.437 -27.863 1.00 32.82  ? 700  TRP A CD1 1 
ATOM   3139 C  CD2 . TRP A 1 437 ? 1.953   -45.497 -27.114 1.00 29.41  ? 700  TRP A CD2 1 
ATOM   3140 N  NE1 . TRP A 1 437 ? 1.488   -43.398 -26.492 1.00 31.16  ? 700  TRP A NE1 1 
ATOM   3141 C  CE2 . TRP A 1 437 ? 1.706   -44.660 -26.014 1.00 27.77  ? 700  TRP A CE2 1 
ATOM   3142 C  CE3 . TRP A 1 437 ? 2.287   -46.823 -26.912 1.00 31.86  ? 700  TRP A CE3 1 
ATOM   3143 C  CZ2 . TRP A 1 437 ? 1.771   -45.123 -24.717 1.00 28.19  ? 700  TRP A CZ2 1 
ATOM   3144 C  CZ3 . TRP A 1 437 ? 2.330   -47.287 -25.627 1.00 32.94  ? 700  TRP A CZ3 1 
ATOM   3145 C  CH2 . TRP A 1 437 ? 2.064   -46.447 -24.551 1.00 31.58  ? 700  TRP A CH2 1 
ATOM   3146 N  N   . ASN A 1 438 ? 4.026   -46.495 -31.983 0.50 36.44  ? 701  ASN A N   1 
ATOM   3147 C  CA  . ASN A 1 438 ? 4.250   -47.016 -33.357 0.50 40.21  ? 701  ASN A CA  1 
ATOM   3148 C  C   . ASN A 1 438 ? 3.090   -47.918 -33.796 0.50 41.04  ? 701  ASN A C   1 
ATOM   3149 O  O   . ASN A 1 438 ? 3.043   -48.244 -34.993 0.50 41.67  ? 701  ASN A O   1 
ATOM   3150 C  CB  . ASN A 1 438 ? 5.588   -47.758 -33.425 0.50 43.41  ? 701  ASN A CB  1 
ATOM   3151 C  CG  . ASN A 1 438 ? 6.727   -46.916 -32.883 0.50 46.98  ? 701  ASN A CG  1 
ATOM   3152 O  OD1 . ASN A 1 438 ? 7.441   -47.335 -31.963 0.50 48.42  ? 701  ASN A OD1 1 
ATOM   3153 N  ND2 . ASN A 1 438 ? 6.880   -45.715 -33.426 0.50 44.61  ? 701  ASN A ND2 1 
ATOM   3154 N  N   . ASP A 1 439 ? 2.205   -48.307 -32.870 1.00 41.60  ? 702  ASP A N   1 
ATOM   3155 C  CA  . ASP A 1 439 ? 1.079   -49.248 -33.142 1.00 47.01  ? 702  ASP A CA  1 
ATOM   3156 C  C   . ASP A 1 439 ? -0.216  -48.664 -32.542 1.00 40.28  ? 702  ASP A C   1 
ATOM   3157 O  O   . ASP A 1 439 ? -0.242  -48.410 -31.332 1.00 39.69  ? 702  ASP A O   1 
ATOM   3158 C  CB  . ASP A 1 439 ? 1.542   -50.615 -32.610 1.00 50.27  ? 702  ASP A CB  1 
ATOM   3159 C  CG  . ASP A 1 439 ? 0.532   -51.755 -32.550 1.00 57.92  ? 702  ASP A CG  1 
ATOM   3160 O  OD1 . ASP A 1 439 ? -0.564  -51.646 -33.188 1.00 55.80  ? 702  ASP A OD1 1 
ATOM   3161 O  OD2 . ASP A 1 439 ? 0.870   -52.764 -31.855 1.00 54.30  ? 702  ASP A OD2 1 
ATOM   3162 N  N   . TRP A 1 440 ? -1.251  -48.458 -33.353 1.00 39.17  ? 703  TRP A N   1 
ATOM   3163 C  CA  . TRP A 1 440 ? -2.549  -47.871 -32.920 1.00 38.69  ? 703  TRP A CA  1 
ATOM   3164 C  C   . TRP A 1 440 ? -3.185  -48.731 -31.812 1.00 34.60  ? 703  TRP A C   1 
ATOM   3165 O  O   . TRP A 1 440 ? -3.910  -48.172 -30.963 1.00 35.03  ? 703  TRP A O   1 
ATOM   3166 C  CB  . TRP A 1 440 ? -3.479  -47.639 -34.112 1.00 37.13  ? 703  TRP A CB  1 
ATOM   3167 C  CG  . TRP A 1 440 ? -3.971  -48.892 -34.781 1.00 40.35  ? 703  TRP A CG  1 
ATOM   3168 C  CD1 . TRP A 1 440 ? -3.456  -49.515 -35.887 1.00 43.89  ? 703  TRP A CD1 1 
ATOM   3169 C  CD2 . TRP A 1 440 ? -5.131  -49.653 -34.425 1.00 40.78  ? 703  TRP A CD2 1 
ATOM   3170 N  NE1 . TRP A 1 440 ? -4.228  -50.596 -36.244 1.00 39.66  ? 703  TRP A NE1 1 
ATOM   3171 C  CE2 . TRP A 1 440 ? -5.223  -50.740 -35.330 1.00 41.20  ? 703  TRP A CE2 1 
ATOM   3172 C  CE3 . TRP A 1 440 ? -6.112  -49.510 -33.449 1.00 38.89  ? 703  TRP A CE3 1 
ATOM   3173 C  CZ2 . TRP A 1 440 ? -6.228  -51.700 -35.251 1.00 39.32  ? 703  TRP A CZ2 1 
ATOM   3174 C  CZ3 . TRP A 1 440 ? -7.097  -50.466 -33.370 1.00 37.90  ? 703  TRP A CZ3 1 
ATOM   3175 C  CH2 . TRP A 1 440 ? -7.153  -51.538 -34.254 1.00 40.90  ? 703  TRP A CH2 1 
ATOM   3176 N  N   . THR A 1 441 ? -2.827  -50.006 -31.728 1.00 32.87  ? 704  THR A N   1 
ATOM   3177 C  CA  . THR A 1 441 ? -3.362  -50.957 -30.704 1.00 34.38  ? 704  THR A CA  1 
ATOM   3178 C  C   . THR A 1 441 ? -2.697  -50.805 -29.329 1.00 34.46  ? 704  THR A C   1 
ATOM   3179 O  O   . THR A 1 441 ? -3.127  -51.480 -28.375 1.00 33.66  ? 704  THR A O   1 
ATOM   3180 C  CB  . THR A 1 441 ? -3.318  -52.406 -31.196 1.00 32.34  ? 704  THR A CB  1 
ATOM   3181 O  OG1 . THR A 1 441 ? -1.971  -52.872 -31.213 1.00 35.22  ? 704  THR A OG1 1 
ATOM   3182 C  CG2 . THR A 1 441 ? -3.949  -52.591 -32.563 1.00 31.01  ? 704  THR A CG2 1 
ATOM   3183 N  N   . GLN A 1 442 ? -1.669  -49.951 -29.229 0.50 35.02  ? 705  GLN A N   1 
ATOM   3184 C  CA  . GLN A 1 442 ? -0.965  -49.611 -27.960 0.50 35.94  ? 705  GLN A CA  1 
ATOM   3185 C  C   . GLN A 1 442 ? -1.369  -48.228 -27.422 0.50 32.17  ? 705  GLN A C   1 
ATOM   3186 O  O   . GLN A 1 442 ? -1.141  -47.990 -26.206 0.50 31.57  ? 705  GLN A O   1 
ATOM   3187 C  CB  . GLN A 1 442 ? 0.543   -49.570 -28.182 0.50 40.45  ? 705  GLN A CB  1 
ATOM   3188 C  CG  . GLN A 1 442 ? 1.063   -50.749 -28.976 0.50 42.26  ? 705  GLN A CG  1 
ATOM   3189 C  CD  . GLN A 1 442 ? 1.573   -51.818 -28.054 0.50 42.44  ? 705  GLN A CD  1 
ATOM   3190 O  OE1 . GLN A 1 442 ? 2.756   -52.152 -28.060 0.50 42.70  ? 705  GLN A OE1 1 
ATOM   3191 N  NE2 . GLN A 1 442 ? 0.671   -52.348 -27.247 0.50 46.84  ? 705  GLN A NE2 1 
ATOM   3192 N  N   . VAL A 1 443 ? -1.901  -47.352 -28.288 1.00 33.15  ? 706  VAL A N   1 
ATOM   3193 C  CA  . VAL A 1 443 ? -2.236  -45.931 -27.937 1.00 35.09  ? 706  VAL A CA  1 
ATOM   3194 C  C   . VAL A 1 443 ? -3.289  -45.917 -26.836 1.00 29.43  ? 706  VAL A C   1 
ATOM   3195 O  O   . VAL A 1 443 ? -4.296  -46.576 -26.975 1.00 30.89  ? 706  VAL A O   1 
ATOM   3196 C  CB  . VAL A 1 443 ? -2.731  -45.148 -29.166 1.00 35.05  ? 706  VAL A CB  1 
ATOM   3197 C  CG1 . VAL A 1 443 ? -3.163  -43.741 -28.816 1.00 44.19  ? 706  VAL A CG1 1 
ATOM   3198 C  CG2 . VAL A 1 443 ? -1.656  -45.088 -30.219 1.00 38.81  ? 706  VAL A CG2 1 
ATOM   3199 N  N   . PRO A 1 444 ? -3.061  -45.198 -25.718 1.00 26.99  ? 707  PRO A N   1 
ATOM   3200 C  CA  . PRO A 1 444 ? -4.122  -44.947 -24.749 1.00 31.42  ? 707  PRO A CA  1 
ATOM   3201 C  C   . PRO A 1 444 ? -5.059  -43.826 -25.238 1.00 30.76  ? 707  PRO A C   1 
ATOM   3202 O  O   . PRO A 1 444 ? -4.590  -42.856 -25.800 1.00 31.64  ? 707  PRO A O   1 
ATOM   3203 C  CB  . PRO A 1 444 ? -3.374  -44.517 -23.511 1.00 31.31  ? 707  PRO A CB  1 
ATOM   3204 C  CG  . PRO A 1 444 ? -2.102  -43.835 -24.073 1.00 34.51  ? 707  PRO A CG  1 
ATOM   3205 C  CD  . PRO A 1 444 ? -1.803  -44.505 -25.407 1.00 30.73  ? 707  PRO A CD  1 
ATOM   3206 N  N   . PHE A 1 445 ? -6.362  -43.990 -25.064 1.00 29.28  ? 708  PHE A N   1 
ATOM   3207 C  CA  . PHE A 1 445 ? -7.374  -42.944 -25.376 1.00 27.76  ? 708  PHE A CA  1 
ATOM   3208 C  C   . PHE A 1 445 ? -8.645  -43.236 -24.581 1.00 28.58  ? 708  PHE A C   1 
ATOM   3209 O  O   . PHE A 1 445 ? -9.124  -44.388 -24.688 1.00 24.78  ? 708  PHE A O   1 
ATOM   3210 C  CB  . PHE A 1 445 ? -7.698  -42.944 -26.875 1.00 30.17  ? 708  PHE A CB  1 
ATOM   3211 C  CG  . PHE A 1 445 ? -8.560  -41.787 -27.350 1.00 35.79  ? 708  PHE A CG  1 
ATOM   3212 C  CD1 . PHE A 1 445 ? -8.288  -40.478 -26.973 1.00 34.66  ? 708  PHE A CD1 1 
ATOM   3213 C  CD2 . PHE A 1 445 ? -9.624  -42.006 -28.206 1.00 36.69  ? 708  PHE A CD2 1 
ATOM   3214 C  CE1 . PHE A 1 445 ? -9.070  -39.419 -27.405 1.00 36.38  ? 708  PHE A CE1 1 
ATOM   3215 C  CE2 . PHE A 1 445 ? -10.377 -40.944 -28.689 1.00 42.56  ? 708  PHE A CE2 1 
ATOM   3216 C  CZ  . PHE A 1 445 ? -10.110 -39.649 -28.264 1.00 39.51  ? 708  PHE A CZ  1 
ATOM   3217 N  N   . CYS A 1 446 ? -9.150  -42.254 -23.836 1.00 29.40  ? 709  CYS A N   1 
ATOM   3218 C  CA  . CYS A 1 446 ? -10.385 -42.328 -22.993 1.00 31.23  ? 709  CYS A CA  1 
ATOM   3219 C  C   . CYS A 1 446 ? -10.336 -43.519 -22.027 1.00 29.77  ? 709  CYS A C   1 
ATOM   3220 O  O   . CYS A 1 446 ? -11.335 -44.275 -21.921 1.00 33.33  ? 709  CYS A O   1 
ATOM   3221 C  CB  . CYS A 1 446 ? -11.628 -42.385 -23.858 1.00 31.96  ? 709  CYS A CB  1 
ATOM   3222 S  SG  . CYS A 1 446 ? -11.769 -40.908 -24.900 1.00 37.50  ? 709  CYS A SG  1 
ATOM   3223 N  N   . SER A 1 447 ? -9.190  -43.709 -21.387 1.00 31.07  ? 710  SER A N   1 
ATOM   3224 C  CA  . SER A 1 447 ? -8.946  -44.730 -20.348 1.00 33.47  ? 710  SER A CA  1 
ATOM   3225 C  C   . SER A 1 447 ? -8.925  -46.135 -20.977 1.00 34.22  ? 710  SER A C   1 
ATOM   3226 O  O   . SER A 1 447 ? -8.957  -47.109 -20.215 1.00 33.94  ? 710  SER A O   1 
ATOM   3227 C  CB  . SER A 1 447 ? -10.005 -44.607 -19.278 1.00 41.97  ? 710  SER A CB  1 
ATOM   3228 O  OG  . SER A 1 447 ? -9.875  -43.363 -18.601 1.00 46.14  ? 710  SER A OG  1 
ATOM   3229 N  N   . HIS A 1 448 ? -8.817  -46.258 -22.297 1.00 30.95  ? 711  HIS A N   1 
ATOM   3230 C  CA  . HIS A 1 448 ? -8.850  -47.566 -23.006 1.00 28.59  ? 711  HIS A CA  1 
ATOM   3231 C  C   . HIS A 1 448 ? -7.651  -47.772 -23.944 1.00 28.29  ? 711  HIS A C   1 
ATOM   3232 O  O   . HIS A 1 448 ? -6.961  -46.799 -24.347 1.00 26.14  ? 711  HIS A O   1 
ATOM   3233 C  CB  . HIS A 1 448 ? -10.141 -47.711 -23.828 1.00 28.18  ? 711  HIS A CB  1 
ATOM   3234 C  CG  . HIS A 1 448 ? -11.340 -47.950 -22.976 1.00 30.68  ? 711  HIS A CG  1 
ATOM   3235 N  ND1 . HIS A 1 448 ? -11.934 -46.942 -22.208 1.00 31.24  ? 711  HIS A ND1 1 
ATOM   3236 C  CD2 . HIS A 1 448 ? -12.027 -49.083 -22.727 1.00 32.82  ? 711  HIS A CD2 1 
ATOM   3237 C  CE1 . HIS A 1 448 ? -12.922 -47.469 -21.506 1.00 33.56  ? 711  HIS A CE1 1 
ATOM   3238 N  NE2 . HIS A 1 448 ? -13.023 -48.783 -21.815 1.00 31.11  ? 711  HIS A NE2 1 
ATOM   3239 N  N   . HIS A 1 449 ? -7.452  -49.014 -24.356 1.00 27.26  ? 712  HIS A N   1 
ATOM   3240 C  CA  . HIS A 1 449 ? -6.711  -49.327 -25.603 1.00 29.22  ? 712  HIS A CA  1 
ATOM   3241 C  C   . HIS A 1 449 ? -7.627  -50.213 -26.433 1.00 27.48  ? 712  HIS A C   1 
ATOM   3242 O  O   . HIS A 1 449 ? -8.656  -50.632 -25.922 1.00 29.34  ? 712  HIS A O   1 
ATOM   3243 C  CB  . HIS A 1 449 ? -5.370  -49.992 -25.298 1.00 26.41  ? 712  HIS A CB  1 
ATOM   3244 C  CG  . HIS A 1 449 ? -5.506  -51.231 -24.497 1.00 25.37  ? 712  HIS A CG  1 
ATOM   3245 N  ND1 . HIS A 1 449 ? -5.623  -51.199 -23.138 1.00 26.43  ? 712  HIS A ND1 1 
ATOM   3246 C  CD2 . HIS A 1 449 ? -5.635  -52.521 -24.867 1.00 25.58  ? 712  HIS A CD2 1 
ATOM   3247 C  CE1 . HIS A 1 449 ? -5.806  -52.430 -22.682 1.00 25.47  ? 712  HIS A CE1 1 
ATOM   3248 N  NE2 . HIS A 1 449 ? -5.761  -53.259 -23.730 1.00 26.68  ? 712  HIS A NE2 1 
ATOM   3249 N  N   . PHE A 1 450 ? -7.229  -50.505 -27.673 0.50 27.82  ? 713  PHE A N   1 
ATOM   3250 C  CA  . PHE A 1 450 ? -8.088  -51.166 -28.686 0.50 29.23  ? 713  PHE A CA  1 
ATOM   3251 C  C   . PHE A 1 450 ? -7.360  -52.359 -29.307 0.50 29.65  ? 713  PHE A C   1 
ATOM   3252 O  O   . PHE A 1 450 ? -6.171  -52.241 -29.668 0.50 30.48  ? 713  PHE A O   1 
ATOM   3253 C  CB  . PHE A 1 450 ? -8.588  -50.106 -29.672 0.50 29.78  ? 713  PHE A CB  1 
ATOM   3254 C  CG  . PHE A 1 450 ? -9.331  -49.007 -28.953 0.50 29.74  ? 713  PHE A CG  1 
ATOM   3255 C  CD1 . PHE A 1 450 ? -8.643  -47.965 -28.353 0.50 30.57  ? 713  PHE A CD1 1 
ATOM   3256 C  CD2 . PHE A 1 450 ? -10.699 -49.066 -28.786 0.50 30.98  ? 713  PHE A CD2 1 
ATOM   3257 C  CE1 . PHE A 1 450 ? -9.315  -46.983 -27.643 0.50 30.48  ? 713  PHE A CE1 1 
ATOM   3258 C  CE2 . PHE A 1 450 ? -11.370 -48.079 -28.079 0.50 32.09  ? 713  PHE A CE2 1 
ATOM   3259 C  CZ  . PHE A 1 450 ? -10.677 -47.042 -27.506 0.50 31.26  ? 713  PHE A CZ  1 
ATOM   3260 N  N   . HIS A 1 451 ? -8.070  -53.491 -29.392 1.00 30.12  ? 714  HIS A N   1 
ATOM   3261 C  CA  . HIS A 1 451 ? -7.592  -54.729 -30.030 1.00 31.71  ? 714  HIS A CA  1 
ATOM   3262 C  C   . HIS A 1 451 ? -8.310  -54.893 -31.365 1.00 31.05  ? 714  HIS A C   1 
ATOM   3263 O  O   . HIS A 1 451 ? -9.504  -54.546 -31.459 1.00 33.96  ? 714  HIS A O   1 
ATOM   3264 C  CB  . HIS A 1 451 ? -7.820  -55.917 -29.096 1.00 31.86  ? 714  HIS A CB  1 
ATOM   3265 C  CG  . HIS A 1 451 ? -7.103  -55.900 -27.779 1.00 31.36  ? 714  HIS A CG  1 
ATOM   3266 N  ND1 . HIS A 1 451 ? -5.993  -56.684 -27.528 1.00 30.10  ? 714  HIS A ND1 1 
ATOM   3267 C  CD2 . HIS A 1 451 ? -7.431  -55.336 -26.588 1.00 34.72  ? 714  HIS A CD2 1 
ATOM   3268 C  CE1 . HIS A 1 451 ? -5.647  -56.549 -26.237 1.00 33.53  ? 714  HIS A CE1 1 
ATOM   3269 N  NE2 . HIS A 1 451 ? -6.518  -55.711 -25.625 1.00 23.61  ? 714  HIS A NE2 1 
ATOM   3270 N  N   . GLU A 1 452 ? -7.585  -55.446 -32.329 1.00 35.80  ? 715  GLU A N   1 
ATOM   3271 C  CA  . GLU A 1 452 ? -8.094  -56.012 -33.595 1.00 37.98  ? 715  GLU A CA  1 
ATOM   3272 C  C   . GLU A 1 452 ? -8.395  -57.480 -33.337 1.00 40.72  ? 715  GLU A C   1 
ATOM   3273 O  O   . GLU A 1 452 ? -7.550  -58.218 -32.857 1.00 42.99  ? 715  GLU A O   1 
ATOM   3274 C  CB  . GLU A 1 452 ? -7.105  -55.847 -34.728 1.00 43.28  ? 715  GLU A CB  1 
ATOM   3275 C  CG  . GLU A 1 452 ? -7.818  -55.282 -35.928 1.00 53.71  ? 715  GLU A CG  1 
ATOM   3276 C  CD  . GLU A 1 452 ? -6.967  -55.110 -37.170 1.00 60.07  ? 715  GLU A CD  1 
ATOM   3277 O  OE1 . GLU A 1 452 ? -7.326  -54.213 -38.009 1.00 54.93  ? 715  GLU A OE1 1 
ATOM   3278 O  OE2 . GLU A 1 452 ? -5.996  -55.904 -37.316 1.00 67.38  ? 715  GLU A OE2 1 
ATOM   3279 N  N   . LEU A 1 453 ? -9.629  -57.883 -33.622 0.40 40.46  ? 716  LEU A N   1 
ATOM   3280 C  CA  . LEU A 1 453 ? -10.146 -59.232 -33.290 0.40 41.94  ? 716  LEU A CA  1 
ATOM   3281 C  C   . LEU A 1 453 ? -10.859 -59.788 -34.524 0.40 42.10  ? 716  LEU A C   1 
ATOM   3282 O  O   . LEU A 1 453 ? -11.831 -59.157 -34.991 0.40 40.34  ? 716  LEU A O   1 
ATOM   3283 C  CB  . LEU A 1 453 ? -11.066 -59.102 -32.075 0.40 44.59  ? 716  LEU A CB  1 
ATOM   3284 C  CG  . LEU A 1 453 ? -11.791 -60.371 -31.637 0.40 48.59  ? 716  LEU A CG  1 
ATOM   3285 C  CD1 . LEU A 1 453 ? -10.801 -61.473 -31.297 0.40 49.25  ? 716  LEU A CD1 1 
ATOM   3286 C  CD2 . LEU A 1 453 ? -12.701 -60.078 -30.450 0.40 50.72  ? 716  LEU A CD2 1 
ATOM   3287 N  N   . ILE A 1 454 ? -10.357 -60.904 -35.053 0.40 43.15  ? 717  ILE A N   1 
ATOM   3288 C  CA  . ILE A 1 454 ? -10.880 -61.548 -36.292 0.40 44.83  ? 717  ILE A CA  1 
ATOM   3289 C  C   . ILE A 1 454 ? -11.901 -62.615 -35.880 0.40 44.28  ? 717  ILE A C   1 
ATOM   3290 O  O   . ILE A 1 454 ? -11.558 -63.497 -35.073 0.40 44.01  ? 717  ILE A O   1 
ATOM   3291 C  CB  . ILE A 1 454 ? -9.721  -62.097 -37.149 0.40 49.35  ? 717  ILE A CB  1 
ATOM   3292 C  CG1 . ILE A 1 454 ? -8.677  -61.011 -37.433 0.40 49.72  ? 717  ILE A CG1 1 
ATOM   3293 C  CG2 . ILE A 1 454 ? -10.243 -62.709 -38.442 0.40 50.17  ? 717  ILE A CG2 1 
ATOM   3294 C  CD1 . ILE A 1 454 ? -7.317  -61.548 -37.811 0.40 51.88  ? 717  ILE A CD1 1 
ATOM   3295 N  N   . MET A 1 455 ? -13.134 -62.488 -36.373 1.00 44.44  ? 718  MET A N   1 
ATOM   3296 C  CA  . MET A 1 455 ? -14.207 -63.486 -36.140 1.00 47.28  ? 718  MET A CA  1 
ATOM   3297 C  C   . MET A 1 455 ? -13.937 -64.731 -36.996 1.00 45.56  ? 718  MET A C   1 
ATOM   3298 O  O   . MET A 1 455 ? -13.243 -64.650 -38.018 1.00 44.68  ? 718  MET A O   1 
ATOM   3299 C  CB  . MET A 1 455 ? -15.562 -62.900 -36.519 1.00 47.10  ? 718  MET A CB  1 
ATOM   3300 C  CG  . MET A 1 455 ? -15.955 -61.752 -35.654 1.00 48.55  ? 718  MET A CG  1 
ATOM   3301 S  SD  . MET A 1 455 ? -17.471 -61.017 -36.271 1.00 49.78  ? 718  MET A SD  1 
ATOM   3302 C  CE  . MET A 1 455 ? -18.618 -62.157 -35.503 1.00 49.41  ? 718  MET A CE  1 
ATOM   3303 N  N   A LYS A 1 456 ? -14.486 -65.865 -36.575 0.20 47.61  ? 719  LYS A N   1 
ATOM   3304 N  N   B LYS A 1 456 ? -14.478 -65.866 -36.553 0.20 47.43  ? 719  LYS A N   1 
ATOM   3305 C  CA  A LYS A 1 456 ? -14.298 -67.175 -37.251 0.20 51.37  ? 719  LYS A CA  1 
ATOM   3306 C  CA  B LYS A 1 456 ? -14.362 -67.185 -37.231 0.20 51.01  ? 719  LYS A CA  1 
ATOM   3307 C  C   A LYS A 1 456 ? -14.730 -67.065 -38.722 0.20 50.14  ? 719  LYS A C   1 
ATOM   3308 C  C   B LYS A 1 456 ? -14.684 -67.018 -38.722 0.20 49.78  ? 719  LYS A C   1 
ATOM   3309 O  O   A LYS A 1 456 ? -14.232 -67.871 -39.526 0.20 52.16  ? 719  LYS A O   1 
ATOM   3310 O  O   B LYS A 1 456 ? -14.062 -67.726 -39.532 0.20 51.48  ? 719  LYS A O   1 
ATOM   3311 C  CB  A LYS A 1 456 ? -15.034 -68.269 -36.473 0.20 54.24  ? 719  LYS A CB  1 
ATOM   3312 C  CB  B LYS A 1 456 ? -15.280 -68.212 -36.557 0.20 53.55  ? 719  LYS A CB  1 
ATOM   3313 C  CG  A LYS A 1 456 ? -14.354 -68.673 -35.171 0.20 57.56  ? 719  LYS A CG  1 
ATOM   3314 C  CG  B LYS A 1 456 ? -15.262 -69.601 -37.184 0.20 57.24  ? 719  LYS A CG  1 
ATOM   3315 C  CD  A LYS A 1 456 ? -15.141 -69.662 -34.340 0.20 59.61  ? 719  LYS A CD  1 
ATOM   3316 C  CD  B LYS A 1 456 ? -15.399 -70.738 -36.185 0.20 58.51  ? 719  LYS A CD  1 
ATOM   3317 C  CE  A LYS A 1 456 ? -16.211 -69.008 -33.493 0.20 61.29  ? 719  LYS A CE  1 
ATOM   3318 C  CE  B LYS A 1 456 ? -15.507 -72.095 -36.850 0.20 58.66  ? 719  LYS A CE  1 
ATOM   3319 N  NZ  A LYS A 1 456 ? -17.279 -69.971 -33.128 0.20 61.69  ? 719  LYS A NZ  1 
ATOM   3320 N  NZ  B LYS A 1 456 ? -15.043 -73.183 -35.958 0.20 59.23  ? 719  LYS A NZ  1 
ATOM   3321 N  N   . ASP A 1 457 ? -15.592 -66.099 -39.069 1.00 48.03  ? 720  ASP A N   1 
ATOM   3322 C  CA  . ASP A 1 457 ? -16.010 -65.858 -40.492 1.00 50.52  ? 720  ASP A CA  1 
ATOM   3323 C  C   . ASP A 1 457 ? -15.181 -64.781 -41.224 1.00 55.31  ? 720  ASP A C   1 
ATOM   3324 O  O   . ASP A 1 457 ? -15.670 -64.314 -42.264 1.00 55.73  ? 720  ASP A O   1 
ATOM   3325 C  CB  . ASP A 1 457 ? -17.484 -65.454 -40.575 1.00 57.97  ? 720  ASP A CB  1 
ATOM   3326 C  CG  . ASP A 1 457 ? -17.823 -64.231 -39.748 1.00 67.29  ? 720  ASP A CG  1 
ATOM   3327 O  OD1 . ASP A 1 457 ? -17.033 -63.252 -39.829 1.00 62.69  ? 720  ASP A OD1 1 
ATOM   3328 O  OD2 . ASP A 1 457 ? -18.849 -64.276 -39.012 1.00 65.99  ? 720  ASP A OD2 1 
ATOM   3329 N  N   . GLY A 1 458 ? -14.035 -64.337 -40.679 1.00 53.93  ? 721  GLY A N   1 
ATOM   3330 C  CA  . GLY A 1 458 ? -13.107 -63.376 -41.305 1.00 51.27  ? 721  GLY A CA  1 
ATOM   3331 C  C   . GLY A 1 458 ? -13.428 -61.916 -41.012 1.00 52.15  ? 721  GLY A C   1 
ATOM   3332 O  O   . GLY A 1 458 ? -12.541 -61.084 -41.177 1.00 57.40  ? 721  GLY A O   1 
ATOM   3333 N  N   . ARG A 1 459 ? -14.639 -61.575 -40.570 1.00 50.13  ? 722  ARG A N   1 
ATOM   3334 C  CA  . ARG A 1 459 ? -14.989 -60.156 -40.327 1.00 42.49  ? 722  ARG A CA  1 
ATOM   3335 C  C   . ARG A 1 459 ? -14.154 -59.600 -39.148 1.00 49.46  ? 722  ARG A C   1 
ATOM   3336 O  O   . ARG A 1 459 ? -13.807 -60.325 -38.172 1.00 41.44  ? 722  ARG A O   1 
ATOM   3337 C  CB  . ARG A 1 459 ? -16.500 -60.036 -40.146 1.00 50.43  ? 722  ARG A CB  1 
ATOM   3338 C  CG  . ARG A 1 459 ? -17.328 -60.428 -41.371 1.00 45.59  ? 722  ARG A CG  1 
ATOM   3339 C  CD  . ARG A 1 459 ? -18.812 -60.118 -41.181 1.00 44.37  ? 722  ARG A CD  1 
ATOM   3340 N  NE  . ARG A 1 459 ? -19.416 -61.022 -40.234 1.00 42.61  ? 722  ARG A NE  1 
ATOM   3341 C  CZ  . ARG A 1 459 ? -20.699 -61.033 -39.904 1.00 51.38  ? 722  ARG A CZ  1 
ATOM   3342 N  NH1 . ARG A 1 459 ? -21.544 -60.176 -40.452 1.00 56.85  ? 722  ARG A NH1 1 
ATOM   3343 N  NH2 . ARG A 1 459 ? -21.147 -61.912 -39.023 1.00 54.01  ? 722  ARG A NH2 1 
ATOM   3344 N  N   . VAL A 1 460 ? -13.860 -58.314 -39.208 1.00 46.14  ? 723  VAL A N   1 
ATOM   3345 C  CA  . VAL A 1 460 ? -12.910 -57.655 -38.277 1.00 43.16  ? 723  VAL A CA  1 
ATOM   3346 C  C   . VAL A 1 460 ? -13.650 -56.802 -37.251 1.00 39.23  ? 723  VAL A C   1 
ATOM   3347 O  O   . VAL A 1 460 ? -14.375 -55.857 -37.633 1.00 47.94  ? 723  VAL A O   1 
ATOM   3348 C  CB  . VAL A 1 460 ? -11.862 -56.865 -39.053 1.00 45.38  ? 723  VAL A CB  1 
ATOM   3349 C  CG1 . VAL A 1 460 ? -10.835 -56.283 -38.098 1.00 58.26  ? 723  VAL A CG1 1 
ATOM   3350 C  CG2 . VAL A 1 460 ? -11.171 -57.794 -40.031 1.00 47.38  ? 723  VAL A CG2 1 
ATOM   3351 N  N   . LEU A 1 461 ? -13.462 -57.131 -35.971 1.00 34.88  ? 724  LEU A N   1 
ATOM   3352 C  CA  . LEU A 1 461 ? -13.935 -56.307 -34.844 1.00 32.65  ? 724  LEU A CA  1 
ATOM   3353 C  C   . LEU A 1 461 ? -12.739 -55.503 -34.314 1.00 37.62  ? 724  LEU A C   1 
ATOM   3354 O  O   . LEU A 1 461 ? -11.601 -56.042 -34.258 1.00 36.88  ? 724  LEU A O   1 
ATOM   3355 C  CB  . LEU A 1 461 ? -14.528 -57.217 -33.774 1.00 37.99  ? 724  LEU A CB  1 
ATOM   3356 C  CG  . LEU A 1 461 ? -15.737 -58.045 -34.233 1.00 32.44  ? 724  LEU A CG  1 
ATOM   3357 C  CD1 . LEU A 1 461 ? -16.085 -59.054 -33.174 1.00 35.85  ? 724  LEU A CD1 1 
ATOM   3358 C  CD2 . LEU A 1 461 ? -16.918 -57.177 -34.571 1.00 33.24  ? 724  LEU A CD2 1 
ATOM   3359 N  N   . VAL A 1 462 ? -12.974 -54.234 -34.015 1.00 32.95  ? 725  VAL A N   1 
ATOM   3360 C  CA  . VAL A 1 462 ? -12.041 -53.383 -33.250 1.00 31.32  ? 725  VAL A CA  1 
ATOM   3361 C  C   . VAL A 1 462 ? -12.727 -53.072 -31.935 1.00 29.67  ? 725  VAL A C   1 
ATOM   3362 O  O   . VAL A 1 462 ? -13.742 -52.354 -31.948 1.00 30.04  ? 725  VAL A O   1 
ATOM   3363 C  CB  . VAL A 1 462 ? -11.617 -52.123 -34.015 1.00 32.22  ? 725  VAL A CB  1 
ATOM   3364 C  CG1 . VAL A 1 462 ? -10.689 -51.293 -33.128 1.00 34.69  ? 725  VAL A CG1 1 
ATOM   3365 C  CG2 . VAL A 1 462 ? -10.917 -52.483 -35.310 1.00 30.23  ? 725  VAL A CG2 1 
ATOM   3366 N  N   . VAL A 1 463 ? -12.185 -53.623 -30.854 1.00 29.59  ? 726  VAL A N   1 
ATOM   3367 C  CA  . VAL A 1 463 ? -12.871 -53.716 -29.543 1.00 28.80  ? 726  VAL A CA  1 
ATOM   3368 C  C   . VAL A 1 463 ? -12.121 -52.888 -28.502 1.00 29.20  ? 726  VAL A C   1 
ATOM   3369 O  O   . VAL A 1 463 ? -10.886 -52.846 -28.519 1.00 33.48  ? 726  VAL A O   1 
ATOM   3370 C  CB  . VAL A 1 463 ? -13.007 -55.189 -29.134 1.00 30.36  ? 726  VAL A CB  1 
ATOM   3371 C  CG1 . VAL A 1 463 ? -13.921 -55.931 -30.087 1.00 31.48  ? 726  VAL A CG1 1 
ATOM   3372 C  CG2 . VAL A 1 463 ? -11.655 -55.891 -29.030 1.00 28.54  ? 726  VAL A CG2 1 
ATOM   3373 N  N   . PRO A 1 464 ? -12.857 -52.220 -27.588 1.00 27.19  ? 727  PRO A N   1 
ATOM   3374 C  CA  . PRO A 1 464 ? -12.248 -51.447 -26.516 1.00 26.14  ? 727  PRO A CA  1 
ATOM   3375 C  C   . PRO A 1 464 ? -11.857 -52.367 -25.376 1.00 28.59  ? 727  PRO A C   1 
ATOM   3376 O  O   . PRO A 1 464 ? -12.467 -53.406 -25.263 1.00 23.77  ? 727  PRO A O   1 
ATOM   3377 C  CB  . PRO A 1 464 ? -13.405 -50.538 -26.075 1.00 25.65  ? 727  PRO A CB  1 
ATOM   3378 C  CG  . PRO A 1 464 ? -14.629 -51.454 -26.232 1.00 28.39  ? 727  PRO A CG  1 
ATOM   3379 C  CD  . PRO A 1 464 ? -14.339 -52.206 -27.521 1.00 28.78  ? 727  PRO A CD  1 
ATOM   3380 N  N   . CYS A 1 465 ? -10.853 -51.966 -24.575 1.00 28.48  ? 728  CYS A N   1 
ATOM   3381 C  CA  . CYS A 1 465 ? -10.247 -52.842 -23.547 1.00 26.79  ? 728  CYS A CA  1 
ATOM   3382 C  C   . CYS A 1 465 ? -9.561  -51.981 -22.489 1.00 29.24  ? 728  CYS A C   1 
ATOM   3383 O  O   . CYS A 1 465 ? -9.118  -50.894 -22.821 1.00 24.55  ? 728  CYS A O   1 
ATOM   3384 C  CB  . CYS A 1 465 ? -9.251  -53.834 -24.168 1.00 26.31  ? 728  CYS A CB  1 
ATOM   3385 S  SG  . CYS A 1 465 ? -8.788  -55.162 -23.016 1.00 28.29  ? 728  CYS A SG  1 
ATOM   3386 N  N   . ARG A 1 466 ? -9.552  -52.428 -21.241 1.00 30.07  ? 729  ARG A N   1 
ATOM   3387 C  CA  . ARG A 1 466 ? -8.660  -51.872 -20.223 1.00 29.51  ? 729  ARG A CA  1 
ATOM   3388 C  C   . ARG A 1 466 ? -8.384  -52.930 -19.163 1.00 27.66  ? 729  ARG A C   1 
ATOM   3389 O  O   . ARG A 1 466 ? -8.997  -53.986 -19.166 1.00 29.59  ? 729  ARG A O   1 
ATOM   3390 C  CB  . ARG A 1 466 ? -9.218  -50.610 -19.589 1.00 33.85  ? 729  ARG A CB  1 
ATOM   3391 C  CG  . ARG A 1 466 ? -10.590 -50.741 -18.976 1.00 36.83  ? 729  ARG A CG  1 
ATOM   3392 C  CD  . ARG A 1 466 ? -11.199 -49.366 -18.693 1.00 33.50  ? 729  ARG A CD  1 
ATOM   3393 N  NE  . ARG A 1 466 ? -10.631 -48.690 -17.553 1.00 35.53  ? 729  ARG A NE  1 
ATOM   3394 C  CZ  . ARG A 1 466 ? -11.114 -47.566 -17.034 1.00 37.91  ? 729  ARG A CZ  1 
ATOM   3395 N  NH1 . ARG A 1 466 ? -12.211 -46.995 -17.509 1.00 42.36  ? 729  ARG A NH1 1 
ATOM   3396 N  NH2 . ARG A 1 466 ? -10.520 -47.033 -16.006 1.00 41.32  ? 729  ARG A NH2 1 
ATOM   3397 N  N   . ASN A 1 467 ? -7.452  -52.642 -18.291 1.00 27.76  ? 730  ASN A N   1 
ATOM   3398 C  CA  . ASN A 1 467 ? -7.127  -53.598 -17.229 1.00 33.08  ? 730  ASN A CA  1 
ATOM   3399 C  C   . ASN A 1 467 ? -8.443  -54.080 -16.578 1.00 27.77  ? 730  ASN A C   1 
ATOM   3400 O  O   . ASN A 1 467 ? -9.168  -53.282 -16.036 1.00 30.26  ? 730  ASN A O   1 
ATOM   3401 C  CB  . ASN A 1 467 ? -6.181  -53.026 -16.192 1.00 31.25  ? 730  ASN A CB  1 
ATOM   3402 C  CG  . ASN A 1 467 ? -5.853  -54.103 -15.192 1.00 33.81  ? 730  ASN A CG  1 
ATOM   3403 O  OD1 . ASN A 1 467 ? -6.463  -54.170 -14.154 1.00 32.91  ? 730  ASN A OD1 1 
ATOM   3404 N  ND2 . ASN A 1 467 ? -4.944  -55.002 -15.544 1.00 47.00  ? 730  ASN A ND2 1 
ATOM   3405 N  N   . GLN A 1 468 ? -8.584  -55.385 -16.452 1.00 27.50  ? 731  GLN A N   1 
ATOM   3406 C  CA  . GLN A 1 468 ? -9.851  -55.984 -16.016 1.00 30.48  ? 731  GLN A CA  1 
ATOM   3407 C  C   . GLN A 1 468 ? -10.101 -55.674 -14.549 1.00 29.91  ? 731  GLN A C   1 
ATOM   3408 O  O   . GLN A 1 468 ? -11.295 -55.627 -14.138 1.00 28.36  ? 731  GLN A O   1 
ATOM   3409 C  CB  . GLN A 1 468 ? -9.862  -57.465 -16.341 1.00 31.36  ? 731  GLN A CB  1 
ATOM   3410 C  CG  . GLN A 1 468 ? -11.233 -58.076 -16.100 1.00 26.71  ? 731  GLN A CG  1 
ATOM   3411 C  CD  . GLN A 1 468 ? -11.191 -59.563 -16.333 1.00 26.91  ? 731  GLN A CD  1 
ATOM   3412 O  OE1 . GLN A 1 468 ? -11.537 -60.046 -17.404 1.00 30.08  ? 731  GLN A OE1 1 
ATOM   3413 N  NE2 . GLN A 1 468 ? -10.828 -60.301 -15.309 1.00 26.54  ? 731  GLN A NE2 1 
ATOM   3414 N  N   . ASP A 1 469 ? -9.045  -55.463 -13.780 1.00 31.44  ? 732  ASP A N   1 
ATOM   3415 C  CA  . ASP A 1 469 ? -9.236  -55.107 -12.350 1.00 32.84  ? 732  ASP A CA  1 
ATOM   3416 C  C   . ASP A 1 469 ? -10.012 -53.788 -12.258 1.00 33.65  ? 732  ASP A C   1 
ATOM   3417 O  O   . ASP A 1 469 ? -10.760 -53.637 -11.318 1.00 32.86  ? 732  ASP A O   1 
ATOM   3418 C  CB  . ASP A 1 469 ? -7.930  -54.962 -11.581 1.00 34.93  ? 732  ASP A CB  1 
ATOM   3419 C  CG  . ASP A 1 469 ? -7.170  -56.283 -11.395 1.00 42.66  ? 732  ASP A CG  1 
ATOM   3420 O  OD1 . ASP A 1 469 ? -7.764  -57.389 -11.566 1.00 40.60  ? 732  ASP A OD1 1 
ATOM   3421 O  OD2 . ASP A 1 469 ? -5.988  -56.191 -11.062 1.00 44.93  ? 732  ASP A OD2 1 
ATOM   3422 N  N   . GLU A 1 470 ? -9.702  -52.831 -13.124 1.00 32.01  ? 733  GLU A N   1 
ATOM   3423 C  CA  . GLU A 1 470 ? -10.376 -51.521 -13.185 1.00 32.50  ? 733  GLU A CA  1 
ATOM   3424 C  C   . GLU A 1 470 ? -11.866 -51.719 -13.518 1.00 31.15  ? 733  GLU A C   1 
ATOM   3425 O  O   . GLU A 1 470 ? -12.686 -51.062 -12.872 1.00 29.08  ? 733  GLU A O   1 
ATOM   3426 C  CB  . GLU A 1 470 ? -9.762  -50.646 -14.272 1.00 33.15  ? 733  GLU A CB  1 
ATOM   3427 C  CG  . GLU A 1 470 ? -8.293  -50.300 -14.030 1.00 39.34  ? 733  GLU A CG  1 
ATOM   3428 C  CD  . GLU A 1 470 ? -7.620  -49.480 -15.126 1.00 42.42  ? 733  GLU A CD  1 
ATOM   3429 O  OE1 . GLU A 1 470 ? -6.393  -49.388 -15.071 1.00 53.82  ? 733  GLU A OE1 1 
ATOM   3430 O  OE2 . GLU A 1 470 ? -8.323  -48.934 -16.043 1.00 39.68  ? 733  GLU A OE2 1 
ATOM   3431 N  N   . LEU A 1 471 ? -12.203 -52.555 -14.501 1.00 26.23  ? 734  LEU A N   1 
ATOM   3432 C  CA  . LEU A 1 471 ? -13.599 -52.831 -14.879 1.00 26.15  ? 734  LEU A CA  1 
ATOM   3433 C  C   . LEU A 1 471 ? -14.362 -53.465 -13.721 1.00 28.28  ? 734  LEU A C   1 
ATOM   3434 O  O   . LEU A 1 471 ? -15.475 -52.978 -13.357 1.00 29.02  ? 734  LEU A O   1 
ATOM   3435 C  CB  . LEU A 1 471 ? -13.592 -53.679 -16.140 1.00 27.81  ? 734  LEU A CB  1 
ATOM   3436 C  CG  . LEU A 1 471 ? -13.029 -52.924 -17.343 1.00 28.28  ? 734  LEU A CG  1 
ATOM   3437 C  CD1 . LEU A 1 471 ? -13.011 -53.812 -18.584 1.00 29.82  ? 734  LEU A CD1 1 
ATOM   3438 C  CD2 . LEU A 1 471 ? -13.849 -51.684 -17.605 1.00 31.32  ? 734  LEU A CD2 1 
ATOM   3439 N  N   . ILE A 1 472 ? -13.818 -54.501 -13.131 1.00 29.35  ? 735  ILE A N   1 
ATOM   3440 C  CA  . ILE A 1 472 ? -14.519 -55.206 -12.031 1.00 28.56  ? 735  ILE A CA  1 
ATOM   3441 C  C   . ILE A 1 472 ? -14.623 -54.291 -10.809 1.00 30.30  ? 735  ILE A C   1 
ATOM   3442 O  O   . ILE A 1 472 ? -15.667 -54.316 -10.146 1.00 25.87  ? 735  ILE A O   1 
ATOM   3443 C  CB  . ILE A 1 472 ? -13.798 -56.515 -11.758 1.00 27.96  ? 735  ILE A CB  1 
ATOM   3444 C  CG1 . ILE A 1 472 ? -14.008 -57.417 -12.967 1.00 30.38  ? 735  ILE A CG1 1 
ATOM   3445 C  CG2 . ILE A 1 472 ? -14.320 -57.124 -10.456 1.00 31.27  ? 735  ILE A CG2 1 
ATOM   3446 C  CD1 . ILE A 1 472 ? -13.328 -58.744 -12.838 1.00 36.85  ? 735  ILE A CD1 1 
ATOM   3447 N  N   . GLY A 1 473 ? -13.559 -53.560 -10.470 1.00 25.15  ? 736  GLY A N   1 
ATOM   3448 C  CA  . GLY A 1 473 ? -13.565 -52.638 -9.310  1.00 27.58  ? 736  GLY A CA  1 
ATOM   3449 C  C   . GLY A 1 473 ? -14.601 -51.501 -9.452  1.00 31.68  ? 736  GLY A C   1 
ATOM   3450 O  O   . GLY A 1 473 ? -15.226 -51.153 -8.434  1.00 30.91  ? 736  GLY A O   1 
ATOM   3451 N  N   . ARG A 1 474 ? -14.843 -50.977 -10.654 1.00 28.75  ? 737  ARG A N   1 
ATOM   3452 C  CA  . ARG A 1 474 ? -15.852 -49.910 -10.879 1.00 31.95  ? 737  ARG A CA  1 
ATOM   3453 C  C   . ARG A 1 474 ? -17.282 -50.498 -10.734 1.00 31.47  ? 737  ARG A C   1 
ATOM   3454 O  O   . ARG A 1 474 ? -18.144 -49.829 -10.150 1.00 34.00  ? 737  ARG A O   1 
ATOM   3455 C  CB  . ARG A 1 474 ? -15.653 -49.251 -12.257 1.00 37.15  ? 737  ARG A CB  1 
ATOM   3456 C  CG  . ARG A 1 474 ? -14.208 -48.873 -12.570 1.00 60.67  ? 737  ARG A CG  1 
ATOM   3457 C  CD  . ARG A 1 474 ? -13.831 -48.608 -14.037 1.00 61.28  ? 737  ARG A CD  1 
ATOM   3458 N  NE  . ARG A 1 474 ? -14.264 -47.247 -14.293 1.00 75.13  ? 737  ARG A NE  1 
ATOM   3459 C  CZ  . ARG A 1 474 ? -13.662 -46.150 -13.830 1.00 71.10  ? 737  ARG A CZ  1 
ATOM   3460 N  NH1 . ARG A 1 474 ? -14.207 -44.977 -14.095 1.00 77.12  ? 737  ARG A NH1 1 
ATOM   3461 N  NH2 . ARG A 1 474 ? -12.526 -46.216 -13.145 1.00 65.51  ? 737  ARG A NH2 1 
ATOM   3462 N  N   . ALA A 1 475 ? -17.557 -51.682 -11.276 1.00 28.47  ? 738  ALA A N   1 
ATOM   3463 C  CA  . ALA A 1 475 ? -18.881 -52.349 -11.196 1.00 26.74  ? 738  ALA A CA  1 
ATOM   3464 C  C   . ALA A 1 475 ? -19.249 -52.677 -9.747  1.00 30.43  ? 738  ALA A C   1 
ATOM   3465 O  O   . ALA A 1 475 ? -20.463 -52.811 -9.450  1.00 31.85  ? 738  ALA A O   1 
ATOM   3466 C  CB  . ALA A 1 475 ? -18.891 -53.611 -12.013 1.00 25.04  ? 738  ALA A CB  1 
ATOM   3467 N  N   . ARG A 1 476 ? -18.257 -52.830 -8.871  1.00 33.42  ? 739  ARG A N   1 
ATOM   3468 C  CA  . ARG A 1 476 ? -18.507 -53.166 -7.440  1.00 33.08  ? 739  ARG A CA  1 
ATOM   3469 C  C   . ARG A 1 476 ? -18.827 -51.913 -6.638  1.00 30.75  ? 739  ARG A C   1 
ATOM   3470 O  O   . ARG A 1 476 ? -19.072 -52.034 -5.430  1.00 32.32  ? 739  ARG A O   1 
ATOM   3471 C  CB  . ARG A 1 476 ? -17.338 -53.974 -6.867  1.00 30.51  ? 739  ARG A CB  1 
ATOM   3472 C  CG  . ARG A 1 476 ? -17.330 -55.397 -7.402  1.00 30.85  ? 739  ARG A CG  1 
ATOM   3473 C  CD  . ARG A 1 476 ? -15.979 -56.091 -7.284  1.00 31.67  ? 739  ARG A CD  1 
ATOM   3474 N  NE  . ARG A 1 476 ? -15.564 -56.331 -5.904  1.00 27.16  ? 739  ARG A NE  1 
ATOM   3475 C  CZ  . ARG A 1 476 ? -15.281 -57.513 -5.367  1.00 27.81  ? 739  ARG A CZ  1 
ATOM   3476 N  NH1 . ARG A 1 476 ? -15.392 -58.636 -6.039  1.00 29.08  ? 739  ARG A NH1 1 
ATOM   3477 N  NH2 . ARG A 1 476 ? -14.826 -57.560 -4.134  1.00 30.57  ? 739  ARG A NH2 1 
ATOM   3478 N  N   . ILE A 1 477 ? -18.898 -50.763 -7.283  1.00 34.57  ? 740  ILE A N   1 
ATOM   3479 C  CA  . ILE A 1 477 ? -19.158 -49.486 -6.565  1.00 46.30  ? 740  ILE A CA  1 
ATOM   3480 C  C   . ILE A 1 477 ? -20.495 -48.891 -7.015  1.00 47.59  ? 740  ILE A C   1 
ATOM   3481 O  O   . ILE A 1 477 ? -20.779 -48.885 -8.196  1.00 42.82  ? 740  ILE A O   1 
ATOM   3482 C  CB  . ILE A 1 477 ? -17.989 -48.511 -6.767  1.00 47.94  ? 740  ILE A CB  1 
ATOM   3483 C  CG1 . ILE A 1 477 ? -16.730 -49.017 -6.049  1.00 48.15  ? 740  ILE A CG1 1 
ATOM   3484 C  CG2 . ILE A 1 477 ? -18.400 -47.128 -6.300  1.00 53.17  ? 740  ILE A CG2 1 
ATOM   3485 C  CD1 . ILE A 1 477 ? -15.506 -48.145 -6.238  1.00 52.17  ? 740  ILE A CD1 1 
ATOM   3486 N  N   . SER A 1 478 ? -21.313 -48.468 -6.048  0.50 52.83  ? 741  SER A N   1 
ATOM   3487 C  CA  . SER A 1 478 ? -22.570 -47.704 -6.264  0.50 58.07  ? 741  SER A CA  1 
ATOM   3488 C  C   . SER A 1 478 ? -22.521 -46.408 -5.444  0.50 63.60  ? 741  SER A C   1 
ATOM   3489 O  O   . SER A 1 478 ? -22.500 -46.488 -4.195  0.50 64.23  ? 741  SER A O   1 
ATOM   3490 C  CB  . SER A 1 478 ? -23.787 -48.540 -5.940  0.50 57.35  ? 741  SER A CB  1 
ATOM   3491 O  OG  . SER A 1 478 ? -23.624 -49.250 -4.723  0.50 55.78  ? 741  SER A OG  1 
ATOM   3492 N  N   . GLN A 1 479 ? -22.463 -45.263 -6.131  0.50 71.49  ? 742  GLN A N   1 
ATOM   3493 C  CA  . GLN A 1 479 ? -22.501 -43.907 -5.519  0.50 77.33  ? 742  GLN A CA  1 
ATOM   3494 C  C   . GLN A 1 479 ? -23.962 -43.534 -5.235  0.50 80.60  ? 742  GLN A C   1 
ATOM   3495 O  O   . GLN A 1 479 ? -24.712 -43.290 -6.210  0.50 75.76  ? 742  GLN A O   1 
ATOM   3496 C  CB  . GLN A 1 479 ? -21.857 -42.871 -6.445  0.50 79.48  ? 742  GLN A CB  1 
ATOM   3497 C  CG  . GLN A 1 479 ? -20.648 -43.390 -7.215  0.50 83.28  ? 742  GLN A CG  1 
ATOM   3498 C  CD  . GLN A 1 479 ? -19.389 -43.449 -6.382  0.50 82.92  ? 742  GLN A CD  1 
ATOM   3499 O  OE1 . GLN A 1 479 ? -19.426 -43.409 -5.153  0.50 80.08  ? 742  GLN A OE1 1 
ATOM   3500 N  NE2 . GLN A 1 479 ? -18.255 -43.548 -7.058  0.50 81.20  ? 742  GLN A NE2 1 
ATOM   3501 N  N   . GLY A 1 480 ? -24.349 -43.508 -3.954  0.50 82.45  ? 743  GLY A N   1 
ATOM   3502 C  CA  . GLY A 1 480 ? -25.680 -43.051 -3.508  0.50 80.87  ? 743  GLY A CA  1 
ATOM   3503 C  C   . GLY A 1 480 ? -26.134 -43.726 -2.224  0.50 78.79  ? 743  GLY A C   1 
ATOM   3504 O  O   . GLY A 1 480 ? -25.586 -44.794 -1.879  0.50 77.48  ? 743  GLY A O   1 
ATOM   3505 N  N   . ALA A 1 481 ? -27.111 -43.111 -1.548  0.50 78.86  ? 744  ALA A N   1 
ATOM   3506 C  CA  . ALA A 1 481 ? -27.756 -43.601 -0.306  0.50 76.16  ? 744  ALA A CA  1 
ATOM   3507 C  C   . ALA A 1 481 ? -29.198 -44.021 -0.613  0.50 69.88  ? 744  ALA A C   1 
ATOM   3508 O  O   . ALA A 1 481 ? -29.708 -43.648 -1.685  0.50 66.46  ? 744  ALA A O   1 
ATOM   3509 C  CB  . ALA A 1 481 ? -27.715 -42.526 0.756   0.50 75.82  ? 744  ALA A CB  1 
ATOM   3510 N  N   . GLY A 1 482 ? -29.815 -44.776 0.301   0.50 65.35  ? 745  GLY A N   1 
ATOM   3511 C  CA  . GLY A 1 482 ? -31.229 -45.193 0.234   0.50 60.05  ? 745  GLY A CA  1 
ATOM   3512 C  C   . GLY A 1 482 ? -31.500 -46.089 -0.957  0.50 57.50  ? 745  GLY A C   1 
ATOM   3513 O  O   . GLY A 1 482 ? -32.625 -46.024 -1.488  0.50 59.43  ? 745  GLY A O   1 
ATOM   3514 N  N   . TRP A 1 483 ? -30.515 -46.895 -1.372  0.50 53.56  ? 746  TRP A N   1 
ATOM   3515 C  CA  . TRP A 1 483 ? -30.649 -47.835 -2.517  0.50 50.95  ? 746  TRP A CA  1 
ATOM   3516 C  C   . TRP A 1 483 ? -31.314 -49.135 -2.046  0.50 45.05  ? 746  TRP A C   1 
ATOM   3517 O  O   . TRP A 1 483 ? -30.763 -49.821 -1.178  0.50 44.16  ? 746  TRP A O   1 
ATOM   3518 C  CB  . TRP A 1 483 ? -29.297 -48.110 -3.178  0.50 56.95  ? 746  TRP A CB  1 
ATOM   3519 C  CG  . TRP A 1 483 ? -28.802 -47.010 -4.064  0.50 62.20  ? 746  TRP A CG  1 
ATOM   3520 C  CD1 . TRP A 1 483 ? -28.449 -45.747 -3.685  0.50 68.62  ? 746  TRP A CD1 1 
ATOM   3521 C  CD2 . TRP A 1 483 ? -28.547 -47.088 -5.477  0.50 65.22  ? 746  TRP A CD2 1 
ATOM   3522 N  NE1 . TRP A 1 483 ? -28.012 -45.028 -4.766  0.50 69.15  ? 746  TRP A NE1 1 
ATOM   3523 C  CE2 . TRP A 1 483 ? -28.064 -45.824 -5.880  0.50 69.33  ? 746  TRP A CE2 1 
ATOM   3524 C  CE3 . TRP A 1 483 ? -28.691 -48.090 -6.442  0.50 66.75  ? 746  TRP A CE3 1 
ATOM   3525 C  CZ2 . TRP A 1 483 ? -27.725 -45.543 -7.203  0.50 69.52  ? 746  TRP A CZ2 1 
ATOM   3526 C  CZ3 . TRP A 1 483 ? -28.359 -47.810 -7.750  0.50 68.84  ? 746  TRP A CZ3 1 
ATOM   3527 C  CH2 . TRP A 1 483 ? -27.886 -46.553 -8.123  0.50 68.76  ? 746  TRP A CH2 1 
ATOM   3528 N  N   . SER A 1 484 ? -32.468 -49.461 -2.618  1.00 40.53  ? 747  SER A N   1 
ATOM   3529 C  CA  . SER A 1 484 ? -33.160 -50.734 -2.343  1.00 40.66  ? 747  SER A CA  1 
ATOM   3530 C  C   . SER A 1 484 ? -32.307 -51.895 -2.897  1.00 36.45  ? 747  SER A C   1 
ATOM   3531 O  O   . SER A 1 484 ? -31.384 -51.631 -3.682  1.00 33.20  ? 747  SER A O   1 
ATOM   3532 C  CB  . SER A 1 484 ? -34.531 -50.682 -2.920  1.00 35.88  ? 747  SER A CB  1 
ATOM   3533 O  OG  . SER A 1 484 ? -34.452 -50.714 -4.320  1.00 35.29  ? 747  SER A OG  1 
ATOM   3534 N  N   . LEU A 1 485 ? -32.638 -53.143 -2.557  1.00 36.34  ? 748  LEU A N   1 
ATOM   3535 C  CA  . LEU A 1 485 ? -32.020 -54.365 -3.158  1.00 37.66  ? 748  LEU A CA  1 
ATOM   3536 C  C   . LEU A 1 485 ? -32.310 -54.398 -4.655  1.00 39.92  ? 748  LEU A C   1 
ATOM   3537 O  O   . LEU A 1 485 ? -31.409 -54.719 -5.472  1.00 40.68  ? 748  LEU A O   1 
ATOM   3538 C  CB  . LEU A 1 485 ? -32.588 -55.604 -2.471  1.00 40.28  ? 748  LEU A CB  1 
ATOM   3539 C  CG  . LEU A 1 485 ? -31.971 -56.923 -2.923  1.00 44.87  ? 748  LEU A CG  1 
ATOM   3540 C  CD1 . LEU A 1 485 ? -30.471 -56.773 -3.077  1.00 42.46  ? 748  LEU A CD1 1 
ATOM   3541 C  CD2 . LEU A 1 485 ? -32.315 -58.038 -1.945  1.00 41.34  ? 748  LEU A CD2 1 
ATOM   3542 N  N   . ARG A 1 486 ? -33.509 -53.951 -5.012  1.00 40.08  ? 749  ARG A N   1 
ATOM   3543 C  CA  . ARG A 1 486 ? -33.968 -53.954 -6.413  1.00 36.66  ? 749  ARG A CA  1 
ATOM   3544 C  C   . ARG A 1 486 ? -33.127 -52.994 -7.276  1.00 31.91  ? 749  ARG A C   1 
ATOM   3545 O  O   . ARG A 1 486 ? -32.733 -53.390 -8.396  1.00 36.11  ? 749  ARG A O   1 
ATOM   3546 C  CB  . ARG A 1 486 ? -35.453 -53.592 -6.506  1.00 37.23  ? 749  ARG A CB  1 
ATOM   3547 C  CG  . ARG A 1 486 ? -35.911 -53.393 -7.944  1.00 35.76  ? 749  ARG A CG  1 
ATOM   3548 C  CD  . ARG A 1 486 ? -37.397 -53.535 -8.045  1.00 41.20  ? 749  ARG A CD  1 
ATOM   3549 N  NE  . ARG A 1 486 ? -37.935 -53.401 -9.401  1.00 41.03  ? 749  ARG A NE  1 
ATOM   3550 C  CZ  . ARG A 1 486 ? -39.066 -53.988 -9.791  1.00 41.63  ? 749  ARG A CZ  1 
ATOM   3551 N  NH1 . ARG A 1 486 ? -39.718 -54.757 -8.940  1.00 37.34  ? 749  ARG A NH1 1 
ATOM   3552 N  NH2 . ARG A 1 486 ? -39.499 -53.874 -11.033 1.00 42.12  ? 749  ARG A NH2 1 
ATOM   3553 N  N   . GLU A 1 487 ? -32.870 -51.771 -6.808  0.50 30.99  ? 750  GLU A N   1 
ATOM   3554 C  CA  . GLU A 1 487 ? -32.125 -50.779 -7.632  0.50 33.45  ? 750  GLU A CA  1 
ATOM   3555 C  C   . GLU A 1 487 ? -30.620 -51.116 -7.620  0.50 33.43  ? 750  GLU A C   1 
ATOM   3556 O  O   . GLU A 1 487 ? -29.947 -50.812 -8.638  0.50 30.29  ? 750  GLU A O   1 
ATOM   3557 C  CB  . GLU A 1 487 ? -32.455 -49.335 -7.240  0.50 35.64  ? 750  GLU A CB  1 
ATOM   3558 C  CG  . GLU A 1 487 ? -32.418 -49.029 -5.755  0.50 38.34  ? 750  GLU A CG  1 
ATOM   3559 C  CD  . GLU A 1 487 ? -33.439 -47.969 -5.354  0.50 37.41  ? 750  GLU A CD  1 
ATOM   3560 O  OE1 . GLU A 1 487 ? -33.366 -47.437 -4.223  0.50 34.01  ? 750  GLU A OE1 1 
ATOM   3561 O  OE2 . GLU A 1 487 ? -34.291 -47.665 -6.190  0.50 41.58  ? 750  GLU A OE2 1 
ATOM   3562 N  N   . THR A 1 488 ? -30.113 -51.751 -6.556  1.00 33.20  ? 751  THR A N   1 
ATOM   3563 C  CA  . THR A 1 488 ? -28.711 -52.270 -6.522  1.00 31.79  ? 751  THR A CA  1 
ATOM   3564 C  C   . THR A 1 488 ? -28.588 -53.357 -7.601  1.00 34.74  ? 751  THR A C   1 
ATOM   3565 O  O   . THR A 1 488 ? -27.577 -53.341 -8.352  1.00 39.51  ? 751  THR A O   1 
ATOM   3566 C  CB  . THR A 1 488 ? -28.350 -52.871 -5.170  1.00 31.23  ? 751  THR A CB  1 
ATOM   3567 O  OG1 . THR A 1 488 ? -28.523 -51.833 -4.200  1.00 36.62  ? 751  THR A OG1 1 
ATOM   3568 C  CG2 . THR A 1 488 ? -26.951 -53.442 -5.157  1.00 28.76  ? 751  THR A CG2 1 
ATOM   3569 N  N   . ALA A 1 489 ? -29.571 -54.263 -7.688  1.00 32.60  ? 752  ALA A N   1 
ATOM   3570 C  CA  . ALA A 1 489 ? -29.593 -55.353 -8.688  1.00 30.35  ? 752  ALA A CA  1 
ATOM   3571 C  C   . ALA A 1 489 ? -29.614 -54.764 -10.108 1.00 33.21  ? 752  ALA A C   1 
ATOM   3572 O  O   . ALA A 1 489 ? -28.929 -55.341 -10.969 1.00 29.55  ? 752  ALA A O   1 
ATOM   3573 C  CB  . ALA A 1 489 ? -30.790 -56.258 -8.452  1.00 32.07  ? 752  ALA A CB  1 
ATOM   3574 N  N   . CYS A 1 490 ? -30.419 -53.710 -10.362 1.00 30.31  ? 753  CYS A N   1 
ATOM   3575 C  CA  . CYS A 1 490 ? -30.609 -53.107 -11.712 1.00 29.98  ? 753  CYS A CA  1 
ATOM   3576 C  C   . CYS A 1 490 ? -29.327 -52.341 -12.101 1.00 28.01  ? 753  CYS A C   1 
ATOM   3577 O  O   . CYS A 1 490 ? -28.978 -52.280 -13.278 1.00 27.17  ? 753  CYS A O   1 
ATOM   3578 C  CB  . CYS A 1 490 ? -31.835 -52.193 -11.764 1.00 34.57  ? 753  CYS A CB  1 
ATOM   3579 S  SG  . CYS A 1 490 ? -33.419 -53.089 -11.600 1.00 36.41  ? 753  CYS A SG  1 
ATOM   3580 N  N   . LEU A 1 491 ? -28.643 -51.730 -11.157 1.00 26.29  ? 754  LEU A N   1 
ATOM   3581 C  CA  . LEU A 1 491 ? -27.290 -51.163 -11.443 1.00 30.38  ? 754  LEU A CA  1 
ATOM   3582 C  C   . LEU A 1 491 ? -26.301 -52.285 -11.806 1.00 31.33  ? 754  LEU A C   1 
ATOM   3583 O  O   . LEU A 1 491 ? -25.553 -52.153 -12.801 1.00 31.74  ? 754  LEU A O   1 
ATOM   3584 C  CB  . LEU A 1 491 ? -26.828 -50.355 -10.230 1.00 32.95  ? 754  LEU A CB  1 
ATOM   3585 C  CG  . LEU A 1 491 ? -25.490 -49.636 -10.420 1.00 34.95  ? 754  LEU A CG  1 
ATOM   3586 C  CD1 . LEU A 1 491 ? -25.532 -48.711 -11.621 1.00 35.35  ? 754  LEU A CD1 1 
ATOM   3587 C  CD2 . LEU A 1 491 ? -25.072 -48.892 -9.166  1.00 32.45  ? 754  LEU A CD2 1 
ATOM   3588 N  N   . GLY A 1 492 ? -26.300 -53.390 -11.067 1.00 32.01  ? 755  GLY A N   1 
ATOM   3589 C  CA  . GLY A 1 492 ? -25.429 -54.509 -11.442 1.00 30.50  ? 755  GLY A CA  1 
ATOM   3590 C  C   . GLY A 1 492 ? -25.720 -54.995 -12.853 1.00 32.65  ? 755  GLY A C   1 
ATOM   3591 O  O   . GLY A 1 492 ? -24.784 -55.297 -13.617 1.00 28.08  ? 755  GLY A O   1 
ATOM   3592 N  N   . LYS A 1 493 ? -26.996 -55.058 -13.220 1.00 28.32  ? 756  LYS A N   1 
ATOM   3593 C  CA  . LYS A 1 493 ? -27.427 -55.488 -14.577 1.00 28.23  ? 756  LYS A CA  1 
ATOM   3594 C  C   . LYS A 1 493 ? -26.971 -54.478 -15.627 1.00 25.70  ? 756  LYS A C   1 
ATOM   3595 O  O   . LYS A 1 493 ? -26.695 -54.902 -16.754 1.00 31.55  ? 756  LYS A O   1 
ATOM   3596 C  CB  . LYS A 1 493 ? -28.964 -55.586 -14.588 1.00 28.13  ? 756  LYS A CB  1 
ATOM   3597 C  CG  . LYS A 1 493 ? -29.579 -56.071 -15.889 1.00 30.73  ? 756  LYS A CG  1 
ATOM   3598 C  CD  . LYS A 1 493 ? -31.028 -56.470 -15.705 1.00 35.03  ? 756  LYS A CD  1 
ATOM   3599 C  CE  . LYS A 1 493 ? -31.692 -56.909 -16.989 1.00 38.09  ? 756  LYS A CE  1 
ATOM   3600 N  NZ  . LYS A 1 493 ? -33.013 -57.534 -16.704 1.00 40.73  ? 756  LYS A NZ  1 
ATOM   3601 N  N   . SER A 1 494 ? -26.960 -53.175 -15.325 1.00 27.79  ? 757  SER A N   1 
ATOM   3602 C  CA  . SER A 1 494 ? -26.400 -52.160 -16.266 1.00 33.66  ? 757  SER A CA  1 
ATOM   3603 C  C   . SER A 1 494 ? -24.915 -52.469 -16.529 1.00 29.91  ? 757  SER A C   1 
ATOM   3604 O  O   . SER A 1 494 ? -24.527 -52.442 -17.676 1.00 28.01  ? 757  SER A O   1 
ATOM   3605 C  CB  . SER A 1 494 ? -26.500 -50.761 -15.784 1.00 35.23  ? 757  SER A CB  1 
ATOM   3606 O  OG  . SER A 1 494 ? -27.834 -50.470 -15.426 1.00 49.20  ? 757  SER A OG  1 
ATOM   3607 N  N   . TYR A 1 495 ? -24.133 -52.780 -15.512 1.00 26.78  ? 758  TYR A N   1 
ATOM   3608 C  CA  . TYR A 1 495 ? -22.695 -53.142 -15.744 1.00 32.68  ? 758  TYR A CA  1 
ATOM   3609 C  C   . TYR A 1 495 ? -22.592 -54.421 -16.576 1.00 29.95  ? 758  TYR A C   1 
ATOM   3610 O  O   . TYR A 1 495 ? -21.834 -54.469 -17.581 1.00 31.75  ? 758  TYR A O   1 
ATOM   3611 C  CB  . TYR A 1 495 ? -21.932 -53.244 -14.422 1.00 29.66  ? 758  TYR A CB  1 
ATOM   3612 C  CG  . TYR A 1 495 ? -21.492 -51.900 -13.931 1.00 29.02  ? 758  TYR A CG  1 
ATOM   3613 C  CD1 . TYR A 1 495 ? -20.393 -51.278 -14.515 1.00 30.24  ? 758  TYR A CD1 1 
ATOM   3614 C  CD2 . TYR A 1 495 ? -22.160 -51.253 -12.905 1.00 31.09  ? 758  TYR A CD2 1 
ATOM   3615 C  CE1 . TYR A 1 495 ? -19.951 -50.047 -14.085 1.00 28.68  ? 758  TYR A CE1 1 
ATOM   3616 C  CE2 . TYR A 1 495 ? -21.732 -50.003 -12.469 1.00 34.12  ? 758  TYR A CE2 1 
ATOM   3617 C  CZ  . TYR A 1 495 ? -20.629 -49.408 -13.066 1.00 35.33  ? 758  TYR A CZ  1 
ATOM   3618 O  OH  . TYR A 1 495 ? -20.199 -48.183 -12.677 1.00 36.32  ? 758  TYR A OH  1 
ATOM   3619 N  N   . ALA A 1 496 ? -23.351 -55.445 -16.187 1.00 30.11  ? 759  ALA A N   1 
ATOM   3620 C  CA  . ALA A 1 496 ? -23.340 -56.736 -16.901 1.00 27.53  ? 759  ALA A CA  1 
ATOM   3621 C  C   . ALA A 1 496 ? -23.613 -56.513 -18.388 1.00 29.38  ? 759  ALA A C   1 
ATOM   3622 O  O   . ALA A 1 496 ? -22.896 -57.114 -19.218 1.00 32.35  ? 759  ALA A O   1 
ATOM   3623 C  CB  . ALA A 1 496 ? -24.357 -57.646 -16.280 1.00 31.83  ? 759  ALA A CB  1 
ATOM   3624 N  N   . GLN A 1 497 ? -24.668 -55.761 -18.743 1.00 28.77  ? 760  GLN A N   1 
ATOM   3625 C  CA  . GLN A 1 497 ? -25.046 -55.561 -20.179 1.00 31.45  ? 760  GLN A CA  1 
ATOM   3626 C  C   . GLN A 1 497 ? -23.964 -54.705 -20.878 1.00 26.94  ? 760  GLN A C   1 
ATOM   3627 O  O   . GLN A 1 497 ? -23.585 -54.991 -22.051 1.00 27.15  ? 760  GLN A O   1 
ATOM   3628 C  CB  . GLN A 1 497 ? -26.484 -54.998 -20.288 1.00 35.54  ? 760  GLN A CB  1 
ATOM   3629 C  CG  . GLN A 1 497 ? -27.534 -55.980 -19.746 1.00 37.62  ? 760  GLN A CG  1 
ATOM   3630 C  CD  . GLN A 1 497 ? -28.995 -55.696 -20.062 1.00 39.08  ? 760  GLN A CD  1 
ATOM   3631 O  OE1 . GLN A 1 497 ? -29.827 -56.612 -20.034 1.00 41.97  ? 760  GLN A OE1 1 
ATOM   3632 N  NE2 . GLN A 1 497 ? -29.322 -54.452 -20.356 1.00 34.57  ? 760  GLN A NE2 1 
ATOM   3633 N  N   . MET A 1 498 ? -23.385 -53.734 -20.183 1.00 26.28  ? 761  MET A N   1 
ATOM   3634 C  CA  . MET A 1 498 ? -22.258 -52.986 -20.784 1.00 26.77  ? 761  MET A CA  1 
ATOM   3635 C  C   . MET A 1 498 ? -21.123 -53.975 -21.101 1.00 26.24  ? 761  MET A C   1 
ATOM   3636 O  O   . MET A 1 498 ? -20.535 -53.939 -22.211 1.00 25.02  ? 761  MET A O   1 
ATOM   3637 C  CB  . MET A 1 498 ? -21.739 -51.889 -19.866 1.00 32.83  ? 761  MET A CB  1 
ATOM   3638 C  CG  . MET A 1 498 ? -20.443 -51.242 -20.441 1.00 39.62  ? 761  MET A CG  1 
ATOM   3639 S  SD  . MET A 1 498 ? -19.832 -50.009 -19.315 1.00 46.09  ? 761  MET A SD  1 
ATOM   3640 C  CE  . MET A 1 498 ? -18.933 -50.993 -18.125 1.00 49.11  ? 761  MET A CE  1 
ATOM   3641 N  N   . TRP A 1 499 ? -20.812 -54.857 -20.177 1.00 24.57  ? 762  TRP A N   1 
ATOM   3642 C  CA  . TRP A 1 499 ? -19.717 -55.837 -20.393 1.00 26.22  ? 762  TRP A CA  1 
ATOM   3643 C  C   . TRP A 1 499 ? -20.023 -56.750 -21.603 1.00 32.70  ? 762  TRP A C   1 
ATOM   3644 O  O   . TRP A 1 499 ? -19.085 -57.027 -22.405 1.00 33.01  ? 762  TRP A O   1 
ATOM   3645 C  CB  . TRP A 1 499 ? -19.499 -56.667 -19.128 1.00 29.61  ? 762  TRP A CB  1 
ATOM   3646 C  CG  . TRP A 1 499 ? -18.896 -55.952 -17.962 1.00 27.57  ? 762  TRP A CG  1 
ATOM   3647 C  CD1 . TRP A 1 499 ? -18.311 -54.725 -17.950 1.00 28.55  ? 762  TRP A CD1 1 
ATOM   3648 C  CD2 . TRP A 1 499 ? -18.701 -56.502 -16.652 1.00 28.10  ? 762  TRP A CD2 1 
ATOM   3649 N  NE1 . TRP A 1 499 ? -17.919 -54.417 -16.680 1.00 30.60  ? 762  TRP A NE1 1 
ATOM   3650 C  CE2 . TRP A 1 499 ? -18.088 -55.509 -15.880 1.00 25.72  ? 762  TRP A CE2 1 
ATOM   3651 C  CE3 . TRP A 1 499 ? -19.060 -57.700 -16.038 1.00 29.00  ? 762  TRP A CE3 1 
ATOM   3652 C  CZ2 . TRP A 1 499 ? -17.748 -55.703 -14.555 1.00 27.70  ? 762  TRP A CZ2 1 
ATOM   3653 C  CZ3 . TRP A 1 499 ? -18.820 -57.853 -14.693 1.00 28.71  ? 762  TRP A CZ3 1 
ATOM   3654 C  CH2 . TRP A 1 499 ? -18.141 -56.883 -13.976 1.00 30.26  ? 762  TRP A CH2 1 
ATOM   3655 N  N   A SER A 1 500 ? -21.268 -57.232 -21.732 0.21 30.81  ? 763  SER A N   1 
ATOM   3656 N  N   B SER A 1 500 ? -21.269 -57.238 -21.738 0.21 30.26  ? 763  SER A N   1 
ATOM   3657 C  CA  A SER A 1 500 ? -21.684 -58.112 -22.855 0.21 30.85  ? 763  SER A CA  1 
ATOM   3658 C  CA  B SER A 1 500 ? -21.662 -58.131 -22.861 0.21 30.01  ? 763  SER A CA  1 
ATOM   3659 C  C   A SER A 1 500 ? -21.551 -57.368 -24.184 0.21 29.47  ? 763  SER A C   1 
ATOM   3660 C  C   B SER A 1 500 ? -21.576 -57.374 -24.190 0.21 28.93  ? 763  SER A C   1 
ATOM   3661 O  O   A SER A 1 500 ? -21.265 -58.023 -25.197 0.21 30.86  ? 763  SER A O   1 
ATOM   3662 O  O   B SER A 1 500 ? -21.335 -58.027 -25.217 0.21 30.18  ? 763  SER A O   1 
ATOM   3663 C  CB  A SER A 1 500 ? -23.081 -58.624 -22.670 0.21 31.91  ? 763  SER A CB  1 
ATOM   3664 C  CB  B SER A 1 500 ? -23.032 -58.754 -22.675 0.21 30.36  ? 763  SER A CB  1 
ATOM   3665 O  OG  A SER A 1 500 ? -23.254 -59.068 -21.338 0.21 34.25  ? 763  SER A OG  1 
ATOM   3666 O  OG  B SER A 1 500 ? -24.067 -57.805 -22.877 0.21 31.84  ? 763  SER A OG  1 
ATOM   3667 N  N   . LEU A 1 501 ? -21.752 -56.052 -24.176 1.00 30.94  ? 764  LEU A N   1 
ATOM   3668 C  CA  . LEU A 1 501 ? -21.714 -55.237 -25.414 1.00 33.46  ? 764  LEU A CA  1 
ATOM   3669 C  C   . LEU A 1 501 ? -20.303 -54.778 -25.760 1.00 32.57  ? 764  LEU A C   1 
ATOM   3670 O  O   . LEU A 1 501 ? -19.950 -54.810 -26.944 1.00 34.40  ? 764  LEU A O   1 
ATOM   3671 C  CB  . LEU A 1 501 ? -22.658 -54.053 -25.211 1.00 39.43  ? 764  LEU A CB  1 
ATOM   3672 C  CG  . LEU A 1 501 ? -23.369 -53.586 -26.470 1.00 55.90  ? 764  LEU A CG  1 
ATOM   3673 C  CD1 . LEU A 1 501 ? -23.921 -54.785 -27.249 1.00 60.83  ? 764  LEU A CD1 1 
ATOM   3674 C  CD2 . LEU A 1 501 ? -24.496 -52.619 -26.081 1.00 60.88  ? 764  LEU A CD2 1 
ATOM   3675 N  N   . MET A 1 502 ? -19.511 -54.356 -24.783 1.00 32.46  ? 765  MET A N   1 
ATOM   3676 C  CA  . MET A 1 502 ? -18.206 -53.706 -25.055 1.00 30.13  ? 765  MET A CA  1 
ATOM   3677 C  C   . MET A 1 502 ? -17.036 -54.674 -24.790 1.00 32.72  ? 765  MET A C   1 
ATOM   3678 O  O   . MET A 1 502 ? -16.090 -54.594 -25.522 1.00 28.74  ? 765  MET A O   1 
ATOM   3679 C  CB  . MET A 1 502 ? -18.035 -52.471 -24.161 1.00 33.35  ? 765  MET A CB  1 
ATOM   3680 C  CG  . MET A 1 502 ? -19.090 -51.385 -24.382 1.00 34.22  ? 765  MET A CG  1 
ATOM   3681 S  SD  . MET A 1 502 ? -19.026 -50.715 -26.054 1.00 37.95  ? 765  MET A SD  1 
ATOM   3682 C  CE  . MET A 1 502 ? -20.072 -51.784 -27.021 1.00 50.39  ? 765  MET A CE  1 
ATOM   3683 N  N   . TYR A 1 503 ? -17.117 -55.521 -23.762 1.00 28.55  ? 766  TYR A N   1 
ATOM   3684 C  CA  . TYR A 1 503 ? -16.001 -56.339 -23.243 1.00 29.73  ? 766  TYR A CA  1 
ATOM   3685 C  C   . TYR A 1 503 ? -16.282 -57.849 -23.399 1.00 30.23  ? 766  TYR A C   1 
ATOM   3686 O  O   . TYR A 1 503 ? -15.745 -58.637 -22.609 1.00 30.42  ? 766  TYR A O   1 
ATOM   3687 C  CB  . TYR A 1 503 ? -15.760 -55.901 -21.796 1.00 30.10  ? 766  TYR A CB  1 
ATOM   3688 C  CG  . TYR A 1 503 ? -15.538 -54.417 -21.617 1.00 30.66  ? 766  TYR A CG  1 
ATOM   3689 C  CD1 . TYR A 1 503 ? -14.513 -53.748 -22.268 1.00 29.03  ? 766  TYR A CD1 1 
ATOM   3690 C  CD2 . TYR A 1 503 ? -16.343 -53.663 -20.774 1.00 34.37  ? 766  TYR A CD2 1 
ATOM   3691 C  CE1 . TYR A 1 503 ? -14.308 -52.385 -22.087 1.00 27.66  ? 766  TYR A CE1 1 
ATOM   3692 C  CE2 . TYR A 1 503 ? -16.184 -52.289 -20.616 1.00 30.66  ? 766  TYR A CE2 1 
ATOM   3693 C  CZ  . TYR A 1 503 ? -15.150 -51.649 -21.268 1.00 31.08  ? 766  TYR A CZ  1 
ATOM   3694 O  OH  . TYR A 1 503 ? -15.012 -50.316 -21.054 1.00 28.92  ? 766  TYR A OH  1 
ATOM   3695 N  N   . PHE A 1 504 ? -17.114 -58.255 -24.369 1.00 31.10  ? 767  PHE A N   1 
ATOM   3696 C  CA  . PHE A 1 504 ? -17.517 -59.670 -24.617 1.00 31.12  ? 767  PHE A CA  1 
ATOM   3697 C  C   . PHE A 1 504 ? -16.277 -60.545 -24.864 1.00 31.49  ? 767  PHE A C   1 
ATOM   3698 O  O   . PHE A 1 504 ? -16.328 -61.778 -24.609 1.00 28.29  ? 767  PHE A O   1 
ATOM   3699 C  CB  . PHE A 1 504 ? -18.438 -59.798 -25.835 1.00 27.16  ? 767  PHE A CB  1 
ATOM   3700 C  CG  . PHE A 1 504 ? -17.964 -59.029 -27.039 1.00 26.26  ? 767  PHE A CG  1 
ATOM   3701 C  CD1 . PHE A 1 504 ? -17.096 -59.604 -27.950 1.00 25.18  ? 767  PHE A CD1 1 
ATOM   3702 C  CD2 . PHE A 1 504 ? -18.326 -57.711 -27.224 1.00 26.78  ? 767  PHE A CD2 1 
ATOM   3703 C  CE1 . PHE A 1 504 ? -16.586 -58.894 -29.023 1.00 23.32  ? 767  PHE A CE1 1 
ATOM   3704 C  CE2 . PHE A 1 504 ? -17.815 -57.009 -28.301 1.00 26.68  ? 767  PHE A CE2 1 
ATOM   3705 C  CZ  . PHE A 1 504 ? -16.954 -57.598 -29.191 1.00 27.34  ? 767  PHE A CZ  1 
ATOM   3706 N  N   . HIS A 1 505 ? -15.197 -59.915 -25.332 1.00 30.95  ? 768  HIS A N   1 
ATOM   3707 C  CA  . HIS A 1 505 ? -13.932 -60.599 -25.750 1.00 30.73  ? 768  HIS A CA  1 
ATOM   3708 C  C   . HIS A 1 505 ? -13.066 -60.990 -24.530 1.00 30.42  ? 768  HIS A C   1 
ATOM   3709 O  O   . HIS A 1 505 ? -12.012 -61.615 -24.722 1.00 34.17  ? 768  HIS A O   1 
ATOM   3710 C  CB  . HIS A 1 505 ? -13.197 -59.725 -26.744 1.00 29.46  ? 768  HIS A CB  1 
ATOM   3711 C  CG  . HIS A 1 505 ? -13.023 -58.348 -26.226 1.00 30.46  ? 768  HIS A CG  1 
ATOM   3712 N  ND1 . HIS A 1 505 ? -11.929 -57.979 -25.469 1.00 30.50  ? 768  HIS A ND1 1 
ATOM   3713 C  CD2 . HIS A 1 505 ? -13.843 -57.267 -26.314 1.00 36.79  ? 768  HIS A CD2 1 
ATOM   3714 C  CE1 . HIS A 1 505 ? -12.086 -56.732 -25.088 1.00 37.37  ? 768  HIS A CE1 1 
ATOM   3715 N  NE2 . HIS A 1 505 ? -13.270 -56.251 -25.604 1.00 34.16  ? 768  HIS A NE2 1 
ATOM   3716 N  N   . ARG A 1 506 ? -13.466 -60.595 -23.321 1.00 26.24  ? 769  ARG A N   1 
ATOM   3717 C  CA  . ARG A 1 506 ? -12.767 -60.880 -22.060 1.00 27.66  ? 769  ARG A CA  1 
ATOM   3718 C  C   . ARG A 1 506 ? -13.542 -62.049 -21.435 1.00 29.06  ? 769  ARG A C   1 
ATOM   3719 O  O   . ARG A 1 506 ? -14.718 -61.868 -21.107 1.00 31.98  ? 769  ARG A O   1 
ATOM   3720 C  CB  . ARG A 1 506 ? -12.741 -59.638 -21.147 1.00 26.80  ? 769  ARG A CB  1 
ATOM   3721 C  CG  . ARG A 1 506 ? -12.125 -58.384 -21.761 1.00 27.33  ? 769  ARG A CG  1 
ATOM   3722 C  CD  . ARG A 1 506 ? -10.766 -58.496 -22.441 1.00 26.40  ? 769  ARG A CD  1 
ATOM   3723 N  NE  . ARG A 1 506 ? -9.868  -59.028 -21.452 1.00 27.66  ? 769  ARG A NE  1 
ATOM   3724 C  CZ  . ARG A 1 506 ? -9.371  -58.363 -20.420 1.00 26.28  ? 769  ARG A CZ  1 
ATOM   3725 N  NH1 . ARG A 1 506 ? -8.733  -59.023 -19.476 1.00 27.36  ? 769  ARG A NH1 1 
ATOM   3726 N  NH2 . ARG A 1 506 ? -9.502  -57.059 -20.306 1.00 29.92  ? 769  ARG A NH2 1 
ATOM   3727 N  N   . ARG A 1 507 ? -12.886 -63.202 -21.271 0.40 28.92  ? 770  ARG A N   1 
ATOM   3728 C  CA  . ARG A 1 507 ? -13.503 -64.466 -20.788 0.40 28.92  ? 770  ARG A CA  1 
ATOM   3729 C  C   . ARG A 1 507 ? -14.196 -64.228 -19.443 0.40 28.54  ? 770  ARG A C   1 
ATOM   3730 O  O   . ARG A 1 507 ? -15.349 -64.672 -19.295 0.40 27.37  ? 770  ARG A O   1 
ATOM   3731 C  CB  . ARG A 1 507 ? -12.448 -65.571 -20.684 0.40 29.32  ? 770  ARG A CB  1 
ATOM   3732 C  CG  . ARG A 1 507 ? -11.983 -66.083 -22.038 0.40 30.43  ? 770  ARG A CG  1 
ATOM   3733 C  CD  . ARG A 1 507 ? -10.732 -66.935 -21.976 0.40 30.94  ? 770  ARG A CD  1 
ATOM   3734 N  NE  . ARG A 1 507 ? -10.424 -67.403 -23.315 0.40 31.01  ? 770  ARG A NE  1 
ATOM   3735 C  CZ  . ARG A 1 507 ? -9.834  -66.677 -24.256 0.40 32.14  ? 770  ARG A CZ  1 
ATOM   3736 N  NH1 . ARG A 1 507 ? -9.445  -65.436 -24.006 0.40 32.37  ? 770  ARG A NH1 1 
ATOM   3737 N  NH2 . ARG A 1 507 ? -9.626  -67.198 -25.451 0.40 32.64  ? 770  ARG A NH2 1 
ATOM   3738 N  N   . ASP A 1 508 ? -13.531 -63.551 -18.504 1.00 27.17  ? 771  ASP A N   1 
ATOM   3739 C  CA  . ASP A 1 508 ? -14.085 -63.392 -17.140 1.00 29.21  ? 771  ASP A CA  1 
ATOM   3740 C  C   . ASP A 1 508 ? -15.339 -62.492 -17.188 1.00 30.62  ? 771  ASP A C   1 
ATOM   3741 O  O   . ASP A 1 508 ? -16.233 -62.661 -16.346 1.00 29.56  ? 771  ASP A O   1 
ATOM   3742 C  CB  . ASP A 1 508 ? -13.036 -62.855 -16.185 1.00 29.34  ? 771  ASP A CB  1 
ATOM   3743 C  CG  . ASP A 1 508 ? -11.857 -63.789 -15.983 1.00 29.17  ? 771  ASP A CG  1 
ATOM   3744 O  OD1 . ASP A 1 508 ? -11.929 -64.971 -16.394 1.00 26.41  ? 771  ASP A OD1 1 
ATOM   3745 O  OD2 . ASP A 1 508 ? -10.875 -63.316 -15.388 1.00 27.34  ? 771  ASP A OD2 1 
ATOM   3746 N  N   . LEU A 1 509 ? -15.361 -61.514 -18.078 1.00 29.58  ? 772  LEU A N   1 
ATOM   3747 C  CA  . LEU A 1 509 ? -16.443 -60.503 -18.085 1.00 30.04  ? 772  LEU A CA  1 
ATOM   3748 C  C   . LEU A 1 509 ? -17.657 -61.109 -18.804 1.00 30.62  ? 772  LEU A C   1 
ATOM   3749 O  O   . LEU A 1 509 ? -18.762 -60.803 -18.415 1.00 29.99  ? 772  LEU A O   1 
ATOM   3750 C  CB  . LEU A 1 509 ? -15.905 -59.215 -18.733 1.00 29.20  ? 772  LEU A CB  1 
ATOM   3751 C  CG  . LEU A 1 509 ? -14.815 -58.455 -17.938 1.00 28.85  ? 772  LEU A CG  1 
ATOM   3752 C  CD1 . LEU A 1 509 ? -14.647 -57.034 -18.466 1.00 27.88  ? 772  LEU A CD1 1 
ATOM   3753 C  CD2 . LEU A 1 509 ? -15.095 -58.430 -16.444 1.00 28.59  ? 772  LEU A CD2 1 
ATOM   3754 N  N   . ARG A 1 510 ? -17.474 -61.945 -19.828 1.00 30.39  ? 773  ARG A N   1 
ATOM   3755 C  CA  . ARG A 1 510 ? -18.635 -62.560 -20.493 1.00 27.97  ? 773  ARG A CA  1 
ATOM   3756 C  C   . ARG A 1 510 ? -19.314 -63.524 -19.520 1.00 31.57  ? 773  ARG A C   1 
ATOM   3757 O  O   . ARG A 1 510 ? -20.578 -63.597 -19.478 1.00 31.99  ? 773  ARG A O   1 
ATOM   3758 C  CB  . ARG A 1 510 ? -18.254 -63.261 -21.780 1.00 29.73  ? 773  ARG A CB  1 
ATOM   3759 C  CG  . ARG A 1 510 ? -19.488 -63.600 -22.619 1.00 31.67  ? 773  ARG A CG  1 
ATOM   3760 C  CD  . ARG A 1 510 ? -19.215 -64.468 -23.821 1.00 30.60  ? 773  ARG A CD  1 
ATOM   3761 N  NE  . ARG A 1 510 ? -18.298 -63.866 -24.772 1.00 28.94  ? 773  ARG A NE  1 
ATOM   3762 C  CZ  . ARG A 1 510 ? -18.109 -64.306 -26.020 1.00 32.05  ? 773  ARG A CZ  1 
ATOM   3763 N  NH1 . ARG A 1 510 ? -18.877 -65.268 -26.477 1.00 34.05  ? 773  ARG A NH1 1 
ATOM   3764 N  NH2 . ARG A 1 510 ? -17.257 -63.716 -26.852 1.00 30.89  ? 773  ARG A NH2 1 
ATOM   3765 N  N   . LEU A 1 511 ? -18.510 -64.251 -18.742 0.40 30.73  ? 774  LEU A N   1 
ATOM   3766 C  CA  . LEU A 1 511 ? -19.004 -65.229 -17.740 0.40 30.84  ? 774  LEU A CA  1 
ATOM   3767 C  C   . LEU A 1 511 ? -19.705 -64.475 -16.604 0.40 30.05  ? 774  LEU A C   1 
ATOM   3768 O  O   . LEU A 1 511 ? -20.817 -64.888 -16.236 0.40 29.76  ? 774  LEU A O   1 
ATOM   3769 C  CB  . LEU A 1 511 ? -17.834 -66.081 -17.230 0.40 31.29  ? 774  LEU A CB  1 
ATOM   3770 C  CG  . LEU A 1 511 ? -18.226 -67.348 -16.467 0.40 32.87  ? 774  LEU A CG  1 
ATOM   3771 C  CD1 . LEU A 1 511 ? -17.156 -68.420 -16.574 0.40 34.02  ? 774  LEU A CD1 1 
ATOM   3772 C  CD2 . LEU A 1 511 ? -18.512 -67.049 -15.003 0.40 34.05  ? 774  LEU A CD2 1 
ATOM   3773 N  N   . ALA A 1 512 ? -19.083 -63.429 -16.053 1.00 28.16  ? 775  ALA A N   1 
ATOM   3774 C  CA  . ALA A 1 512 ? -19.672 -62.678 -14.922 1.00 29.01  ? 775  ALA A CA  1 
ATOM   3775 C  C   . ALA A 1 512 ? -20.964 -61.949 -15.388 1.00 28.65  ? 775  ALA A C   1 
ATOM   3776 O  O   . ALA A 1 512 ? -21.912 -61.897 -14.620 1.00 30.92  ? 775  ALA A O   1 
ATOM   3777 C  CB  . ALA A 1 512 ? -18.673 -61.751 -14.293 1.00 23.94  ? 775  ALA A CB  1 
ATOM   3778 N  N   . ALA A 1 513 ? -21.007 -61.460 -16.630 1.00 28.19  ? 776  ALA A N   1 
ATOM   3779 C  CA  . ALA A 1 513 ? -22.153 -60.733 -17.217 1.00 30.40  ? 776  ALA A CA  1 
ATOM   3780 C  C   . ALA A 1 513 ? -23.332 -61.701 -17.310 1.00 33.71  ? 776  ALA A C   1 
ATOM   3781 O  O   . ALA A 1 513 ? -24.487 -61.309 -16.908 1.00 31.07  ? 776  ALA A O   1 
ATOM   3782 C  CB  . ALA A 1 513 ? -21.814 -60.144 -18.578 1.00 28.27  ? 776  ALA A CB  1 
ATOM   3783 N  N   . ASN A 1 514 ? -23.067 -62.892 -17.844 1.00 31.10  ? 777  ASN A N   1 
ATOM   3784 C  CA  . ASN A 1 514 ? -24.086 -63.971 -17.934 1.00 35.42  ? 777  ASN A CA  1 
ATOM   3785 C  C   . ASN A 1 514 ? -24.558 -64.351 -16.537 1.00 34.49  ? 777  ASN A C   1 
ATOM   3786 O  O   . ASN A 1 514 ? -25.779 -64.441 -16.351 1.00 36.04  ? 777  ASN A O   1 
ATOM   3787 C  CB  . ASN A 1 514 ? -23.576 -65.180 -18.697 1.00 32.50  ? 777  ASN A CB  1 
ATOM   3788 C  CG  . ASN A 1 514 ? -23.503 -64.856 -20.167 1.00 36.36  ? 777  ASN A CG  1 
ATOM   3789 O  OD1 . ASN A 1 514 ? -24.354 -64.142 -20.703 1.00 36.48  ? 777  ASN A OD1 1 
ATOM   3790 N  ND2 . ASN A 1 514 ? -22.476 -65.360 -20.827 1.00 39.86  ? 777  ASN A ND2 1 
ATOM   3791 N  N   . ALA A 1 515 ? -23.653 -64.465 -15.571 1.00 31.27  ? 778  ALA A N   1 
ATOM   3792 C  CA  . ALA A 1 515 ? -24.064 -64.779 -14.188 1.00 29.21  ? 778  ALA A CA  1 
ATOM   3793 C  C   . ALA A 1 515 ? -24.945 -63.657 -13.635 1.00 32.21  ? 778  ALA A C   1 
ATOM   3794 O  O   . ALA A 1 515 ? -25.928 -63.962 -13.013 1.00 31.02  ? 778  ALA A O   1 
ATOM   3795 C  CB  . ALA A 1 515 ? -22.903 -65.065 -13.302 1.00 26.71  ? 778  ALA A CB  1 
ATOM   3796 N  N   . ILE A 1 516 ? -24.580 -62.395 -13.769 1.00 33.56  ? 779  ILE A N   1 
ATOM   3797 C  CA  . ILE A 1 516 ? -25.387 -61.305 -13.149 1.00 35.64  ? 779  ILE A CA  1 
ATOM   3798 C  C   . ILE A 1 516 ? -26.773 -61.275 -13.822 1.00 35.40  ? 779  ILE A C   1 
ATOM   3799 O  O   . ILE A 1 516 ? -27.761 -61.210 -13.097 1.00 32.65  ? 779  ILE A O   1 
ATOM   3800 C  CB  . ILE A 1 516 ? -24.664 -59.943 -13.218 1.00 30.54  ? 779  ILE A CB  1 
ATOM   3801 C  CG1 . ILE A 1 516 ? -23.436 -59.964 -12.328 1.00 30.73  ? 779  ILE A CG1 1 
ATOM   3802 C  CG2 . ILE A 1 516 ? -25.580 -58.768 -12.863 1.00 27.95  ? 779  ILE A CG2 1 
ATOM   3803 C  CD1 . ILE A 1 516 ? -22.413 -58.941 -12.734 1.00 32.75  ? 779  ILE A CD1 1 
ATOM   3804 N  N   . CYS A 1 517 ? -26.847 -61.337 -15.150 1.00 35.52  ? 780  CYS A N   1 
ATOM   3805 C  CA  . CYS A 1 517 ? -28.133 -61.318 -15.886 1.00 35.40  ? 780  CYS A CA  1 
ATOM   3806 C  C   . CYS A 1 517 ? -28.982 -62.553 -15.536 1.00 38.37  ? 780  CYS A C   1 
ATOM   3807 O  O   . CYS A 1 517 ? -30.215 -62.450 -15.592 1.00 35.67  ? 780  CYS A O   1 
ATOM   3808 C  CB  . CYS A 1 517 ? -27.914 -61.163 -17.377 1.00 32.74  ? 780  CYS A CB  1 
ATOM   3809 S  SG  . CYS A 1 517 ? -27.239 -59.524 -17.762 1.00 38.02  ? 780  CYS A SG  1 
ATOM   3810 N  N   . SER A 1 518 ? -28.368 -63.640 -15.098 1.00 34.01  ? 781  SER A N   1 
ATOM   3811 C  CA  . SER A 1 518 ? -29.069 -64.871 -14.674 1.00 35.21  ? 781  SER A CA  1 
ATOM   3812 C  C   . SER A 1 518 ? -29.586 -64.653 -13.255 1.00 34.44  ? 781  SER A C   1 
ATOM   3813 O  O   . SER A 1 518 ? -30.647 -65.209 -12.910 1.00 33.70  ? 781  SER A O   1 
ATOM   3814 C  CB  . SER A 1 518 ? -28.165 -66.072 -14.761 1.00 35.49  ? 781  SER A CB  1 
ATOM   3815 O  OG  . SER A 1 518 ? -27.912 -66.396 -16.118 1.00 39.88  ? 781  SER A OG  1 
ATOM   3816 N  N   . ALA A 1 519 ? -28.918 -63.784 -12.495 1.00 31.41  ? 782  ALA A N   1 
ATOM   3817 C  CA  . ALA A 1 519 ? -29.161 -63.610 -11.039 1.00 33.24  ? 782  ALA A CA  1 
ATOM   3818 C  C   . ALA A 1 519 ? -30.204 -62.510 -10.763 1.00 31.00  ? 782  ALA A C   1 
ATOM   3819 O  O   . ALA A 1 519 ? -30.717 -62.479 -9.663  1.00 33.39  ? 782  ALA A O   1 
ATOM   3820 C  CB  . ALA A 1 519 ? -27.861 -63.369 -10.292 1.00 36.41  ? 782  ALA A CB  1 
ATOM   3821 N  N   . VAL A 1 520 ? -30.393 -61.594 -11.688 1.00 31.04  ? 783  VAL A N   1 
ATOM   3822 C  CA  . VAL A 1 520 ? -31.359 -60.483 -11.621 1.00 34.10  ? 783  VAL A CA  1 
ATOM   3823 C  C   . VAL A 1 520 ? -32.603 -60.855 -12.446 1.00 34.74  ? 783  VAL A C   1 
ATOM   3824 O  O   . VAL A 1 520 ? -32.496 -61.393 -13.548 1.00 31.45  ? 783  VAL A O   1 
ATOM   3825 C  CB  . VAL A 1 520 ? -30.726 -59.179 -12.123 1.00 36.18  ? 783  VAL A CB  1 
ATOM   3826 C  CG1 . VAL A 1 520 ? -31.716 -58.008 -11.987 1.00 34.03  ? 783  VAL A CG1 1 
ATOM   3827 C  CG2 . VAL A 1 520 ? -29.410 -58.857 -11.394 1.00 32.70  ? 783  VAL A CG2 1 
ATOM   3828 N  N   . PRO A 1 521 ? -33.823 -60.589 -11.922 1.00 32.27  ? 784  PRO A N   1 
ATOM   3829 C  CA  . PRO A 1 521 ? -35.056 -60.874 -12.659 1.00 31.21  ? 784  PRO A CA  1 
ATOM   3830 C  C   . PRO A 1 521 ? -34.905 -60.450 -14.124 1.00 32.89  ? 784  PRO A C   1 
ATOM   3831 O  O   . PRO A 1 521 ? -34.715 -59.280 -14.335 1.00 33.58  ? 784  PRO A O   1 
ATOM   3832 C  CB  . PRO A 1 521 ? -36.098 -60.118 -11.831 1.00 31.33  ? 784  PRO A CB  1 
ATOM   3833 C  CG  . PRO A 1 521 ? -35.594 -60.270 -10.425 1.00 35.86  ? 784  PRO A CG  1 
ATOM   3834 C  CD  . PRO A 1 521 ? -34.103 -60.065 -10.577 1.00 32.25  ? 784  PRO A CD  1 
ATOM   3835 N  N   A SER A 1 522 ? -35.341 -61.305 -15.052 0.20 34.34  ? 785  SER A N   1 
ATOM   3836 N  N   B SER A 1 522 ? -35.348 -61.303 -15.051 0.20 33.56  ? 785  SER A N   1 
ATOM   3837 C  CA  A SER A 1 522 ? -35.174 -61.009 -16.501 0.20 37.66  ? 785  SER A CA  1 
ATOM   3838 C  CA  B SER A 1 522 ? -35.176 -61.010 -16.500 0.20 36.31  ? 785  SER A CA  1 
ATOM   3839 C  C   A SER A 1 522 ? -35.793 -59.669 -16.906 0.20 39.70  ? 785  SER A C   1 
ATOM   3840 C  C   B SER A 1 522 ? -35.792 -59.669 -16.905 0.20 38.87  ? 785  SER A C   1 
ATOM   3841 O  O   A SER A 1 522 ? -35.284 -59.075 -17.872 0.20 40.06  ? 785  SER A O   1 
ATOM   3842 O  O   B SER A 1 522 ? -35.277 -59.070 -17.865 0.20 39.28  ? 785  SER A O   1 
ATOM   3843 C  CB  A SER A 1 522 ? -35.758 -62.131 -17.318 0.20 41.63  ? 785  SER A CB  1 
ATOM   3844 C  CB  B SER A 1 522 ? -35.777 -62.126 -17.306 0.20 39.15  ? 785  SER A CB  1 
ATOM   3845 O  OG  A SER A 1 522 ? -37.128 -62.323 -17.002 0.20 43.95  ? 785  SER A OG  1 
ATOM   3846 O  OG  B SER A 1 522 ? -35.672 -63.358 -16.608 0.20 39.14  ? 785  SER A OG  1 
ATOM   3847 N  N   . HIS A 1 523 ? -36.988 -59.362 -16.396 1.00 40.72  ? 786  HIS A N   1 
ATOM   3848 C  CA  . HIS A 1 523 ? -37.691 -58.114 -16.814 1.00 38.87  ? 786  HIS A CA  1 
ATOM   3849 C  C   . HIS A 1 523 ? -37.327 -56.865 -16.001 1.00 37.31  ? 786  HIS A C   1 
ATOM   3850 O  O   . HIS A 1 523 ? -37.831 -55.803 -16.360 1.00 41.59  ? 786  HIS A O   1 
ATOM   3851 C  CB  . HIS A 1 523 ? -39.200 -58.384 -16.807 1.00 43.08  ? 786  HIS A CB  1 
ATOM   3852 C  CG  . HIS A 1 523 ? -39.604 -59.467 -17.746 1.00 44.57  ? 786  HIS A CG  1 
ATOM   3853 N  ND1 . HIS A 1 523 ? -39.845 -60.755 -17.324 1.00 45.86  ? 786  HIS A ND1 1 
ATOM   3854 C  CD2 . HIS A 1 523 ? -39.790 -59.463 -19.082 1.00 54.55  ? 786  HIS A CD2 1 
ATOM   3855 C  CE1 . HIS A 1 523 ? -40.175 -61.498 -18.358 1.00 51.79  ? 786  HIS A CE1 1 
ATOM   3856 N  NE2 . HIS A 1 523 ? -40.146 -60.729 -19.447 1.00 56.59  ? 786  HIS A NE2 1 
ATOM   3857 N  N   . TRP A 1 524 ? -36.477 -56.966 -14.982 1.00 37.94  ? 787  TRP A N   1 
ATOM   3858 C  CA  . TRP A 1 524 ? -36.057 -55.742 -14.247 1.00 37.29  ? 787  TRP A CA  1 
ATOM   3859 C  C   . TRP A 1 524 ? -35.225 -54.848 -15.172 1.00 37.48  ? 787  TRP A C   1 
ATOM   3860 O  O   . TRP A 1 524 ? -34.375 -55.377 -15.885 1.00 37.10  ? 787  TRP A O   1 
ATOM   3861 C  CB  . TRP A 1 524 ? -35.384 -56.081 -12.916 1.00 38.83  ? 787  TRP A CB  1 
ATOM   3862 C  CG  . TRP A 1 524 ? -36.358 -56.540 -11.876 1.00 41.33  ? 787  TRP A CG  1 
ATOM   3863 C  CD1 . TRP A 1 524 ? -37.681 -56.818 -12.059 1.00 41.04  ? 787  TRP A CD1 1 
ATOM   3864 C  CD2 . TRP A 1 524 ? -36.093 -56.774 -10.482 1.00 39.07  ? 787  TRP A CD2 1 
ATOM   3865 N  NE1 . TRP A 1 524 ? -38.255 -57.210 -10.882 1.00 39.32  ? 787  TRP A NE1 1 
ATOM   3866 C  CE2 . TRP A 1 524 ? -37.306 -57.193 -9.896  1.00 37.85  ? 787  TRP A CE2 1 
ATOM   3867 C  CE3 . TRP A 1 524 ? -34.955 -56.676 -9.676  1.00 39.61  ? 787  TRP A CE3 1 
ATOM   3868 C  CZ2 . TRP A 1 524 ? -37.408 -57.510 -8.544  1.00 37.76  ? 787  TRP A CZ2 1 
ATOM   3869 C  CZ3 . TRP A 1 524 ? -35.057 -56.991 -8.341  1.00 42.58  ? 787  TRP A CZ3 1 
ATOM   3870 C  CH2 . TRP A 1 524 ? -36.267 -57.401 -7.785  1.00 37.10  ? 787  TRP A CH2 1 
ATOM   3871 N  N   . VAL A 1 525 ? -35.461 -53.542 -15.133 1.00 36.42  ? 788  VAL A N   1 
ATOM   3872 C  CA  . VAL A 1 525 ? -34.847 -52.614 -16.116 1.00 42.62  ? 788  VAL A CA  1 
ATOM   3873 C  C   . VAL A 1 525 ? -33.517 -52.126 -15.530 1.00 40.13  ? 788  VAL A C   1 
ATOM   3874 O  O   . VAL A 1 525 ? -33.447 -51.673 -14.387 1.00 41.28  ? 788  VAL A O   1 
ATOM   3875 C  CB  . VAL A 1 525 ? -35.786 -51.431 -16.451 1.00 46.72  ? 788  VAL A CB  1 
ATOM   3876 C  CG1 . VAL A 1 525 ? -35.196 -50.519 -17.514 1.00 46.16  ? 788  VAL A CG1 1 
ATOM   3877 C  CG2 . VAL A 1 525 ? -37.186 -51.876 -16.841 1.00 45.33  ? 788  VAL A CG2 1 
ATOM   3878 N  N   . PRO A 1 526 ? -32.432 -52.151 -16.317 1.00 43.97  ? 789  PRO A N   1 
ATOM   3879 C  CA  . PRO A 1 526 ? -31.165 -51.539 -15.903 1.00 44.35  ? 789  PRO A CA  1 
ATOM   3880 C  C   . PRO A 1 526 ? -31.253 -50.028 -15.620 1.00 49.14  ? 789  PRO A C   1 
ATOM   3881 O  O   . PRO A 1 526 ? -31.884 -49.327 -16.411 1.00 46.52  ? 789  PRO A O   1 
ATOM   3882 C  CB  . PRO A 1 526 ? -30.283 -51.737 -17.127 1.00 42.23  ? 789  PRO A CB  1 
ATOM   3883 C  CG  . PRO A 1 526 ? -30.919 -52.824 -17.947 1.00 42.16  ? 789  PRO A CG  1 
ATOM   3884 C  CD  . PRO A 1 526 ? -32.386 -52.793 -17.639 1.00 42.99  ? 789  PRO A CD  1 
ATOM   3885 N  N   . THR A 1 527 ? -30.646 -49.572 -14.514 0.50 52.78  ? 790  THR A N   1 
ATOM   3886 C  CA  . THR A 1 527 ? -30.692 -48.164 -14.026 0.50 60.66  ? 790  THR A CA  1 
ATOM   3887 C  C   . THR A 1 527 ? -29.282 -47.619 -13.791 0.50 62.97  ? 790  THR A C   1 
ATOM   3888 O  O   . THR A 1 527 ? -28.361 -48.431 -13.600 0.50 58.95  ? 790  THR A O   1 
ATOM   3889 C  CB  . THR A 1 527 ? -31.468 -48.022 -12.710 0.50 65.49  ? 790  THR A CB  1 
ATOM   3890 O  OG1 . THR A 1 527 ? -30.705 -48.599 -11.646 0.50 67.57  ? 790  THR A OG1 1 
ATOM   3891 C  CG2 . THR A 1 527 ? -32.839 -48.655 -12.773 0.50 68.72  ? 790  THR A CG2 1 
ATOM   3892 N  N   . SER A 1 528 ? -29.169 -46.286 -13.773 0.50 72.46  ? 791  SER A N   1 
ATOM   3893 C  CA  . SER A 1 528 ? -27.946 -45.487 -13.497 0.50 82.00  ? 791  SER A CA  1 
ATOM   3894 C  C   . SER A 1 528 ? -28.363 -44.063 -13.104 0.50 92.66  ? 791  SER A C   1 
ATOM   3895 O  O   . SER A 1 528 ? -28.953 -43.369 -13.964 0.50 92.24  ? 791  SER A O   1 
ATOM   3896 C  CB  . SER A 1 528 ? -27.034 -45.484 -14.695 0.50 81.97  ? 791  SER A CB  1 
ATOM   3897 O  OG  . SER A 1 528 ? -26.116 -44.405 -14.632 0.50 84.66  ? 791  SER A OG  1 
ATOM   3898 N  N   . ARG A 1 529 ? -28.064 -43.650 -11.864 0.50 105.43 ? 792  ARG A N   1 
ATOM   3899 C  CA  . ARG A 1 529 ? -28.559 -42.391 -11.230 0.50 112.18 ? 792  ARG A CA  1 
ATOM   3900 C  C   . ARG A 1 529 ? -28.155 -41.166 -12.068 0.50 120.45 ? 792  ARG A C   1 
ATOM   3901 O  O   . ARG A 1 529 ? -29.012 -40.271 -12.243 0.50 117.89 ? 792  ARG A O   1 
ATOM   3902 C  CB  . ARG A 1 529 ? -28.059 -42.291 -9.785  0.50 111.10 ? 792  ARG A CB  1 
ATOM   3903 C  CG  . ARG A 1 529 ? -28.766 -43.242 -8.828  0.50 113.44 ? 792  ARG A CG  1 
ATOM   3904 C  CD  . ARG A 1 529 ? -28.604 -42.889 -7.358  0.50 113.14 ? 792  ARG A CD  1 
ATOM   3905 N  NE  . ARG A 1 529 ? -29.356 -43.797 -6.499  0.50 109.79 ? 792  ARG A NE  1 
ATOM   3906 C  CZ  . ARG A 1 529 ? -29.437 -43.699 -5.176  0.50 104.65 ? 792  ARG A CZ  1 
ATOM   3907 N  NH1 . ARG A 1 529 ? -28.809 -42.723 -4.544  0.50 104.50 ? 792  ARG A NH1 1 
ATOM   3908 N  NH2 . ARG A 1 529 ? -30.147 -44.579 -4.492  0.50 99.57  ? 792  ARG A NH2 1 
ATOM   3909 N  N   . THR A 1 530 ? -26.907 -41.118 -12.553 0.50 126.97 ? 793  THR A N   1 
ATOM   3910 C  CA  . THR A 1 530 ? -26.390 -40.077 -13.489 0.50 129.82 ? 793  THR A CA  1 
ATOM   3911 C  C   . THR A 1 530 ? -25.433 -40.724 -14.499 0.50 132.76 ? 793  THR A C   1 
ATOM   3912 O  O   . THR A 1 530 ? -25.802 -40.756 -15.693 0.50 135.15 ? 793  THR A O   1 
ATOM   3913 C  CB  . THR A 1 530 ? -25.708 -38.920 -12.745 0.50 125.61 ? 793  THR A CB  1 
ATOM   3914 O  OG1 . THR A 1 530 ? -24.824 -39.451 -11.758 0.50 129.89 ? 793  THR A OG1 1 
ATOM   3915 C  CG2 . THR A 1 530 ? -26.694 -37.984 -12.083 0.50 123.79 ? 793  THR A CG2 1 
ATOM   3916 N  N   . ALA A 1 536 ? -21.991 -40.627 -23.687 1.00 122.93 ? 799  ALA A N   1 
ATOM   3917 C  CA  . ALA A 1 536 ? -21.720 -41.246 -25.005 1.00 113.67 ? 799  ALA A CA  1 
ATOM   3918 C  C   . ALA A 1 536 ? -22.948 -42.034 -25.470 1.00 106.03 ? 799  ALA A C   1 
ATOM   3919 O  O   . ALA A 1 536 ? -24.075 -41.628 -25.135 1.00 113.61 ? 799  ALA A O   1 
ATOM   3920 C  CB  . ALA A 1 536 ? -20.512 -42.138 -24.903 1.00 118.35 ? 799  ALA A CB  1 
ATOM   3921 N  N   . THR A 1 537 ? -22.730 -43.122 -26.207 0.50 95.04  ? 800  THR A N   1 
ATOM   3922 C  CA  . THR A 1 537 ? -23.866 -43.978 -26.626 0.50 87.34  ? 800  THR A CA  1 
ATOM   3923 C  C   . THR A 1 537 ? -23.974 -45.148 -25.649 0.50 81.10  ? 800  THR A C   1 
ATOM   3924 O  O   . THR A 1 537 ? -22.916 -45.740 -25.376 0.50 79.11  ? 800  THR A O   1 
ATOM   3925 C  CB  . THR A 1 537 ? -23.693 -44.441 -28.076 0.50 88.76  ? 800  THR A CB  1 
ATOM   3926 O  OG1 . THR A 1 537 ? -22.781 -45.539 -28.080 0.50 92.08  ? 800  THR A OG1 1 
ATOM   3927 C  CG2 . THR A 1 537 ? -23.187 -43.344 -28.986 0.50 88.45  ? 800  THR A CG2 1 
ATOM   3928 N  N   A HIS A 1 538 ? -25.059 -45.182 -24.870 0.25 68.34  ? 801  HIS A N   1 
ATOM   3929 N  N   B HIS A 1 538 ? -25.054 -45.177 -24.863 0.25 75.70  ? 801  HIS A N   1 
ATOM   3930 C  CA  A HIS A 1 538 ? -25.258 -46.279 -23.884 0.25 58.87  ? 801  HIS A CA  1 
ATOM   3931 C  CA  B HIS A 1 538 ? -25.259 -46.278 -23.883 0.25 67.81  ? 801  HIS A CA  1 
ATOM   3932 C  C   A HIS A 1 538 ? -26.316 -47.249 -24.415 0.25 51.94  ? 801  HIS A C   1 
ATOM   3933 C  C   B HIS A 1 538 ? -26.317 -47.245 -24.419 0.25 56.56  ? 801  HIS A C   1 
ATOM   3934 O  O   A HIS A 1 538 ? -27.331 -47.420 -23.716 0.25 44.56  ? 801  HIS A O   1 
ATOM   3935 O  O   B HIS A 1 538 ? -27.336 -47.413 -23.724 0.25 48.59  ? 801  HIS A O   1 
ATOM   3936 C  CB  A HIS A 1 538 ? -25.596 -45.691 -22.509 0.25 55.40  ? 801  HIS A CB  1 
ATOM   3937 C  CB  B HIS A 1 538 ? -25.618 -45.695 -22.512 0.25 70.24  ? 801  HIS A CB  1 
ATOM   3938 C  CG  A HIS A 1 538 ? -24.466 -44.925 -21.909 0.25 51.86  ? 801  HIS A CG  1 
ATOM   3939 C  CG  B HIS A 1 538 ? -26.576 -44.555 -22.593 0.25 73.61  ? 801  HIS A CG  1 
ATOM   3940 N  ND1 A HIS A 1 538 ? -24.103 -45.059 -20.584 0.25 50.88  ? 801  HIS A ND1 1 
ATOM   3941 N  ND1 B HIS A 1 538 ? -26.158 -43.239 -22.588 0.25 75.68  ? 801  HIS A ND1 1 
ATOM   3942 C  CD2 A HIS A 1 538 ? -23.607 -44.033 -22.449 0.25 48.92  ? 801  HIS A CD2 1 
ATOM   3943 C  CD2 B HIS A 1 538 ? -27.922 -44.526 -22.695 0.25 73.18  ? 801  HIS A CD2 1 
ATOM   3944 C  CE1 A HIS A 1 538 ? -23.075 -44.275 -20.331 0.25 49.36  ? 801  HIS A CE1 1 
ATOM   3945 C  CE1 B HIS A 1 538 ? -27.207 -42.446 -22.677 0.25 75.95  ? 801  HIS A CE1 1 
ATOM   3946 N  NE2 A HIS A 1 538 ? -22.752 -43.635 -21.460 0.25 49.58  ? 801  HIS A NE2 1 
ATOM   3947 N  NE2 B HIS A 1 538 ? -28.302 -43.212 -22.744 0.25 74.23  ? 801  HIS A NE2 1 
ATOM   3948 N  N   . GLU A 1 539 ? -25.921 -48.104 -25.362 1.00 47.65  ? 802  GLU A N   1 
ATOM   3949 C  CA  . GLU A 1 539 ? -26.877 -49.072 -25.963 1.00 52.18  ? 802  GLU A CA  1 
ATOM   3950 C  C   . GLU A 1 539 ? -27.191 -50.232 -25.007 1.00 48.32  ? 802  GLU A C   1 
ATOM   3951 O  O   . GLU A 1 539 ? -28.145 -50.961 -25.290 1.00 50.93  ? 802  GLU A O   1 
ATOM   3952 C  CB  . GLU A 1 539 ? -26.316 -49.590 -27.283 1.00 57.61  ? 802  GLU A CB  1 
ATOM   3953 C  CG  . GLU A 1 539 ? -26.329 -48.570 -28.402 1.00 61.83  ? 802  GLU A CG  1 
ATOM   3954 C  CD  . GLU A 1 539 ? -25.138 -47.632 -28.407 1.00 69.12  ? 802  GLU A CD  1 
ATOM   3955 O  OE1 . GLU A 1 539 ? -24.943 -46.940 -29.420 1.00 88.59  ? 802  GLU A OE1 1 
ATOM   3956 O  OE2 . GLU A 1 539 ? -24.410 -47.598 -27.398 1.00 74.32  ? 802  GLU A OE2 1 
ATOM   3957 N  N   . TRP A 1 540 ? -26.427 -50.384 -23.927 1.00 39.91  ? 803  TRP A N   1 
ATOM   3958 C  CA  . TRP A 1 540 ? -26.656 -51.470 -22.937 1.00 45.16  ? 803  TRP A CA  1 
ATOM   3959 C  C   . TRP A 1 540 ? -27.833 -51.132 -22.016 1.00 42.19  ? 803  TRP A C   1 
ATOM   3960 O  O   . TRP A 1 540 ? -28.280 -52.016 -21.292 1.00 40.54  ? 803  TRP A O   1 
ATOM   3961 C  CB  . TRP A 1 540 ? -25.372 -51.753 -22.142 1.00 40.45  ? 803  TRP A CB  1 
ATOM   3962 C  CG  . TRP A 1 540 ? -24.782 -50.579 -21.428 1.00 34.51  ? 803  TRP A CG  1 
ATOM   3963 C  CD1 . TRP A 1 540 ? -25.076 -50.149 -20.168 1.00 39.41  ? 803  TRP A CD1 1 
ATOM   3964 C  CD2 . TRP A 1 540 ? -23.763 -49.696 -21.924 1.00 36.25  ? 803  TRP A CD2 1 
ATOM   3965 N  NE1 . TRP A 1 540 ? -24.323 -49.052 -19.852 1.00 39.36  ? 803  TRP A NE1 1 
ATOM   3966 C  CE2 . TRP A 1 540 ? -23.507 -48.752 -20.909 1.00 38.14  ? 803  TRP A CE2 1 
ATOM   3967 C  CE3 . TRP A 1 540 ? -23.050 -49.607 -23.123 1.00 41.86  ? 803  TRP A CE3 1 
ATOM   3968 C  CZ2 . TRP A 1 540 ? -22.569 -47.735 -21.061 1.00 42.33  ? 803  TRP A CZ2 1 
ATOM   3969 C  CZ3 . TRP A 1 540 ? -22.124 -48.601 -23.272 1.00 44.13  ? 803  TRP A CZ3 1 
ATOM   3970 C  CH2 . TRP A 1 540 ? -21.888 -47.679 -22.254 1.00 41.96  ? 803  TRP A CH2 1 
ATOM   3971 N  N   . MET A 1 541 ? -28.301 -49.886 -22.047 1.00 46.94  ? 804  MET A N   1 
ATOM   3972 C  CA  . MET A 1 541 ? -29.409 -49.449 -21.158 1.00 46.71  ? 804  MET A CA  1 
ATOM   3973 C  C   . MET A 1 541 ? -30.732 -49.806 -21.835 1.00 49.00  ? 804  MET A C   1 
ATOM   3974 O  O   . MET A 1 541 ? -31.335 -48.917 -22.450 1.00 47.66  ? 804  MET A O   1 
ATOM   3975 C  CB  . MET A 1 541 ? -29.329 -47.949 -20.870 1.00 51.04  ? 804  MET A CB  1 
ATOM   3976 C  CG  . MET A 1 541 ? -28.070 -47.540 -20.132 1.00 52.40  ? 804  MET A CG  1 
ATOM   3977 S  SD  . MET A 1 541 ? -27.854 -48.418 -18.567 1.00 53.87  ? 804  MET A SD  1 
ATOM   3978 C  CE  . MET A 1 541 ? -29.242 -47.786 -17.630 1.00 61.89  ? 804  MET A CE  1 
ATOM   3979 N  N   . THR A 1 542 ? -31.138 -51.068 -21.724 1.00 43.61  ? 805  THR A N   1 
ATOM   3980 C  CA  . THR A 1 542 ? -32.361 -51.557 -22.393 1.00 48.49  ? 805  THR A CA  1 
ATOM   3981 C  C   . THR A 1 542 ? -32.741 -52.928 -21.850 1.00 46.89  ? 805  THR A C   1 
ATOM   3982 O  O   . THR A 1 542 ? -31.892 -53.563 -21.219 1.00 41.26  ? 805  THR A O   1 
ATOM   3983 C  CB  . THR A 1 542 ? -32.150 -51.732 -23.900 1.00 56.47  ? 805  THR A CB  1 
ATOM   3984 O  OG1 . THR A 1 542 ? -33.299 -52.373 -24.451 1.00 53.56  ? 805  THR A OG1 1 
ATOM   3985 C  CG2 . THR A 1 542 ? -30.918 -52.545 -24.230 1.00 55.39  ? 805  THR A CG2 1 
ATOM   3986 N  N   . THR A 1 543 ? -33.976 -53.347 -22.092 1.00 41.19  ? 806  THR A N   1 
ATOM   3987 C  CA  . THR A 1 543 ? -34.456 -54.709 -21.700 1.00 46.63  ? 806  THR A CA  1 
ATOM   3988 C  C   . THR A 1 543 ? -34.532 -55.599 -22.947 1.00 43.61  ? 806  THR A C   1 
ATOM   3989 O  O   . THR A 1 543 ? -34.935 -56.749 -22.815 1.00 41.68  ? 806  THR A O   1 
ATOM   3990 C  CB  . THR A 1 543 ? -35.811 -54.669 -20.968 1.00 55.50  ? 806  THR A CB  1 
ATOM   3991 O  OG1 . THR A 1 543 ? -36.707 -53.837 -21.713 1.00 48.18  ? 806  THR A OG1 1 
ATOM   3992 C  CG2 . THR A 1 543 ? -35.682 -54.162 -19.545 1.00 58.32  ? 806  THR A CG2 1 
ATOM   3993 N  N   . GLU A 1 544 ? -34.136 -55.093 -24.106 1.00 42.30  ? 807  GLU A N   1 
ATOM   3994 C  CA  . GLU A 1 544 ? -33.988 -55.925 -25.328 1.00 43.83  ? 807  GLU A CA  1 
ATOM   3995 C  C   . GLU A 1 544 ? -32.946 -57.020 -25.090 1.00 43.47  ? 807  GLU A C   1 
ATOM   3996 O  O   . GLU A 1 544 ? -32.094 -56.891 -24.179 1.00 40.41  ? 807  GLU A O   1 
ATOM   3997 C  CB  . GLU A 1 544 ? -33.588 -55.044 -26.497 1.00 50.20  ? 807  GLU A CB  1 
ATOM   3998 C  CG  . GLU A 1 544 ? -33.813 -55.698 -27.824 1.00 58.60  ? 807  GLU A CG  1 
ATOM   3999 C  CD  . GLU A 1 544 ? -33.675 -54.727 -28.986 1.00 67.63  ? 807  GLU A CD  1 
ATOM   4000 O  OE1 . GLU A 1 544 ? -34.145 -55.099 -30.115 1.00 69.71  ? 807  GLU A OE1 1 
ATOM   4001 O  OE2 . GLU A 1 544 ? -33.106 -53.602 -28.767 1.00 54.38  ? 807  GLU A OE2 1 
ATOM   4002 N  N   . ASP A 1 545 ? -33.060 -58.097 -25.849 1.00 45.03  ? 808  ASP A N   1 
ATOM   4003 C  CA  . ASP A 1 545 ? -32.135 -59.251 -25.856 1.00 46.69  ? 808  ASP A CA  1 
ATOM   4004 C  C   . ASP A 1 545 ? -30.732 -58.736 -26.228 1.00 46.83  ? 808  ASP A C   1 
ATOM   4005 O  O   . ASP A 1 545 ? -30.619 -58.056 -27.257 1.00 42.48  ? 808  ASP A O   1 
ATOM   4006 C  CB  . ASP A 1 545 ? -32.612 -60.293 -26.868 1.00 50.75  ? 808  ASP A CB  1 
ATOM   4007 C  CG  . ASP A 1 545 ? -31.645 -61.433 -27.098 1.00 61.71  ? 808  ASP A CG  1 
ATOM   4008 O  OD1 . ASP A 1 545 ? -31.027 -61.890 -26.114 1.00 77.66  ? 808  ASP A OD1 1 
ATOM   4009 O  OD2 . ASP A 1 545 ? -31.510 -61.847 -28.265 1.00 80.82  ? 808  ASP A OD2 1 
ATOM   4010 N  N   . MET A 1 546 ? -29.701 -59.078 -25.456 1.00 41.13  ? 809  MET A N   1 
ATOM   4011 C  CA  . MET A 1 546 ? -28.323 -58.506 -25.671 1.00 39.87  ? 809  MET A CA  1 
ATOM   4012 C  C   . MET A 1 546 ? -27.713 -59.077 -26.957 1.00 35.48  ? 809  MET A C   1 
ATOM   4013 O  O   . MET A 1 546 ? -27.013 -58.295 -27.637 1.00 32.79  ? 809  MET A O   1 
ATOM   4014 C  CB  . MET A 1 546 ? -27.408 -58.696 -24.462 1.00 42.51  ? 809  MET A CB  1 
ATOM   4015 C  CG  . MET A 1 546 ? -27.732 -57.731 -23.308 1.00 45.47  ? 809  MET A CG  1 
ATOM   4016 S  SD  . MET A 1 546 ? -27.467 -55.981 -23.715 1.00 52.39  ? 809  MET A SD  1 
ATOM   4017 C  CE  . MET A 1 546 ? -29.128 -55.419 -24.018 1.00 62.77  ? 809  MET A CE  1 
ATOM   4018 N  N   . LEU A 1 547 ? -28.054 -60.300 -27.389 1.00 32.11  ? 810  LEU A N   1 
ATOM   4019 C  CA  . LEU A 1 547 ? -27.515 -60.743 -28.705 1.00 35.19  ? 810  LEU A CA  1 
ATOM   4020 C  C   . LEU A 1 547 ? -28.087 -59.847 -29.807 1.00 39.90  ? 810  LEU A C   1 
ATOM   4021 O  O   . LEU A 1 547 ? -27.342 -59.594 -30.785 1.00 40.19  ? 810  LEU A O   1 
ATOM   4022 C  CB  . LEU A 1 547 ? -27.799 -62.210 -29.002 1.00 38.20  ? 810  LEU A CB  1 
ATOM   4023 C  CG  . LEU A 1 547 ? -27.173 -62.735 -30.303 1.00 41.35  ? 810  LEU A CG  1 
ATOM   4024 C  CD1 . LEU A 1 547 ? -25.647 -62.636 -30.290 1.00 41.54  ? 810  LEU A CD1 1 
ATOM   4025 C  CD2 . LEU A 1 547 ? -27.569 -64.169 -30.524 1.00 43.06  ? 810  LEU A CD2 1 
ATOM   4026 N  N   . THR A 1 548 ? -29.331 -59.391 -29.686 1.00 37.77  ? 811  THR A N   1 
ATOM   4027 C  CA  . THR A 1 548 ? -29.957 -58.559 -30.748 1.00 38.00  ? 811  THR A CA  1 
ATOM   4028 C  C   . THR A 1 548 ? -29.259 -57.191 -30.799 1.00 34.81  ? 811  THR A C   1 
ATOM   4029 O  O   . THR A 1 548 ? -28.925 -56.748 -31.897 1.00 34.51  ? 811  THR A O   1 
ATOM   4030 C  CB  . THR A 1 548 ? -31.478 -58.496 -30.564 1.00 43.14  ? 811  THR A CB  1 
ATOM   4031 O  OG1 . THR A 1 548 ? -31.986 -59.826 -30.665 1.00 43.44  ? 811  THR A OG1 1 
ATOM   4032 C  CG2 . THR A 1 548 ? -32.158 -57.601 -31.575 1.00 43.44  ? 811  THR A CG2 1 
ATOM   4033 N  N   . VAL A 1 549 ? -29.023 -56.575 -29.645 1.00 32.31  ? 812  VAL A N   1 
ATOM   4034 C  CA  . VAL A 1 549 ? -28.283 -55.283 -29.577 1.00 41.31  ? 812  VAL A CA  1 
ATOM   4035 C  C   . VAL A 1 549 ? -26.856 -55.453 -30.120 1.00 36.11  ? 812  VAL A C   1 
ATOM   4036 O  O   . VAL A 1 549 ? -26.403 -54.571 -30.843 1.00 35.01  ? 812  VAL A O   1 
ATOM   4037 C  CB  . VAL A 1 549 ? -28.266 -54.724 -28.142 1.00 45.14  ? 812  VAL A CB  1 
ATOM   4038 C  CG1 . VAL A 1 549 ? -27.523 -53.400 -28.063 1.00 41.71  ? 812  VAL A CG1 1 
ATOM   4039 C  CG2 . VAL A 1 549 ? -29.670 -54.588 -27.575 1.00 51.70  ? 812  VAL A CG2 1 
ATOM   4040 N  N   . TRP A 1 550 ? -26.183 -56.550 -29.772 1.00 35.77  ? 813  TRP A N   1 
ATOM   4041 C  CA  . TRP A 1 550 ? -24.798 -56.787 -30.259 1.00 36.59  ? 813  TRP A CA  1 
ATOM   4042 C  C   . TRP A 1 550 ? -24.793 -56.765 -31.791 1.00 40.05  ? 813  TRP A C   1 
ATOM   4043 O  O   . TRP A 1 550 ? -23.929 -56.091 -32.354 1.00 37.73  ? 813  TRP A O   1 
ATOM   4044 C  CB  . TRP A 1 550 ? -24.214 -58.090 -29.700 1.00 31.59  ? 813  TRP A CB  1 
ATOM   4045 C  CG  . TRP A 1 550 ? -22.748 -58.274 -29.943 1.00 33.37  ? 813  TRP A CG  1 
ATOM   4046 C  CD1 . TRP A 1 550 ? -21.739 -58.085 -29.045 1.00 34.59  ? 813  TRP A CD1 1 
ATOM   4047 C  CD2 . TRP A 1 550 ? -22.119 -58.695 -31.165 1.00 32.97  ? 813  TRP A CD2 1 
ATOM   4048 N  NE1 . TRP A 1 550 ? -20.530 -58.354 -29.622 1.00 38.14  ? 813  TRP A NE1 1 
ATOM   4049 C  CE2 . TRP A 1 550 ? -20.730 -58.729 -30.923 1.00 34.98  ? 813  TRP A CE2 1 
ATOM   4050 C  CE3 . TRP A 1 550 ? -22.588 -59.048 -32.434 1.00 35.50  ? 813  TRP A CE3 1 
ATOM   4051 C  CZ2 . TRP A 1 550 ? -19.812 -59.097 -31.903 1.00 33.41  ? 813  TRP A CZ2 1 
ATOM   4052 C  CZ3 . TRP A 1 550 ? -21.680 -59.411 -33.402 1.00 37.18  ? 813  TRP A CZ3 1 
ATOM   4053 C  CH2 . TRP A 1 550 ? -20.312 -59.435 -33.138 1.00 37.47  ? 813  TRP A CH2 1 
ATOM   4054 N  N   . ASN A 1 551 ? -25.745 -57.458 -32.420 0.40 38.77  ? 814  ASN A N   1 
ATOM   4055 C  CA  . ASN A 1 551 ? -25.811 -57.529 -33.904 0.40 40.28  ? 814  ASN A CA  1 
ATOM   4056 C  C   . ASN A 1 551 ? -26.039 -56.129 -34.483 0.40 37.72  ? 814  ASN A C   1 
ATOM   4057 O  O   . ASN A 1 551 ? -25.418 -55.804 -35.504 0.40 35.72  ? 814  ASN A O   1 
ATOM   4058 C  CB  . ASN A 1 551 ? -26.888 -58.515 -34.366 0.40 42.55  ? 814  ASN A CB  1 
ATOM   4059 C  CG  . ASN A 1 551 ? -26.412 -59.951 -34.378 0.40 45.08  ? 814  ASN A CG  1 
ATOM   4060 O  OD1 . ASN A 1 551 ? -25.454 -60.284 -35.070 0.40 46.43  ? 814  ASN A OD1 1 
ATOM   4061 N  ND2 . ASN A 1 551 ? -27.082 -60.810 -33.628 0.40 46.42  ? 814  ASN A ND2 1 
ATOM   4062 N  N   . ARG A 1 552 ? -26.905 -55.341 -33.849 1.00 37.31  ? 815  ARG A N   1 
ATOM   4063 C  CA  . ARG A 1 552 ? -27.213 -53.974 -34.342 1.00 39.15  ? 815  ARG A CA  1 
ATOM   4064 C  C   . ARG A 1 552 ? -25.975 -53.077 -34.226 1.00 45.50  ? 815  ARG A C   1 
ATOM   4065 O  O   . ARG A 1 552 ? -25.672 -52.382 -35.203 1.00 43.01  ? 815  ARG A O   1 
ATOM   4066 C  CB  . ARG A 1 552 ? -28.386 -53.390 -33.554 1.00 41.57  ? 815  ARG A CB  1 
ATOM   4067 C  CG  . ARG A 1 552 ? -28.778 -51.976 -33.950 1.00 44.55  ? 815  ARG A CG  1 
ATOM   4068 C  CD  . ARG A 1 552 ? -29.822 -51.425 -32.999 1.00 48.79  ? 815  ARG A CD  1 
ATOM   4069 N  NE  . ARG A 1 552 ? -30.958 -52.327 -32.894 1.00 61.64  ? 815  ARG A NE  1 
ATOM   4070 C  CZ  . ARG A 1 552 ? -31.543 -52.688 -31.758 1.00 61.62  ? 815  ARG A CZ  1 
ATOM   4071 N  NH1 . ARG A 1 552 ? -31.105 -52.217 -30.604 1.00 56.00  ? 815  ARG A NH1 1 
ATOM   4072 N  NH2 . ARG A 1 552 ? -32.569 -53.517 -31.783 1.00 66.08  ? 815  ARG A NH2 1 
ATOM   4073 N  N   . VAL A 1 553 ? -25.283 -53.118 -33.087 1.00 37.81  ? 816  VAL A N   1 
ATOM   4074 C  CA  . VAL A 1 553 ? -24.126 -52.209 -32.840 1.00 36.56  ? 816  VAL A CA  1 
ATOM   4075 C  C   . VAL A 1 553 ? -22.879 -52.663 -33.609 1.00 36.76  ? 816  VAL A C   1 
ATOM   4076 O  O   . VAL A 1 553 ? -22.250 -51.806 -34.225 1.00 40.88  ? 816  VAL A O   1 
ATOM   4077 C  CB  . VAL A 1 553 ? -23.850 -52.093 -31.328 1.00 37.31  ? 816  VAL A CB  1 
ATOM   4078 C  CG1 . VAL A 1 553 ? -22.530 -51.402 -31.038 1.00 40.87  ? 816  VAL A CG1 1 
ATOM   4079 C  CG2 . VAL A 1 553 ? -24.993 -51.418 -30.589 1.00 33.84  ? 816  VAL A CG2 1 
ATOM   4080 N  N   . TRP A 1 554 ? -22.571 -53.956 -33.617 1.00 33.68  ? 817  TRP A N   1 
ATOM   4081 C  CA  . TRP A 1 554 ? -21.287 -54.430 -34.199 1.00 30.68  ? 817  TRP A CA  1 
ATOM   4082 C  C   . TRP A 1 554 ? -21.394 -54.800 -35.683 1.00 37.19  ? 817  TRP A C   1 
ATOM   4083 O  O   . TRP A 1 554 ? -20.351 -54.855 -36.331 1.00 33.65  ? 817  TRP A O   1 
ATOM   4084 C  CB  . TRP A 1 554 ? -20.734 -55.581 -33.347 1.00 30.29  ? 817  TRP A CB  1 
ATOM   4085 C  CG  . TRP A 1 554 ? -20.225 -55.133 -32.012 1.00 31.25  ? 817  TRP A CG  1 
ATOM   4086 C  CD1 . TRP A 1 554 ? -20.826 -55.297 -30.799 1.00 31.66  ? 817  TRP A CD1 1 
ATOM   4087 C  CD2 . TRP A 1 554 ? -19.006 -54.415 -31.760 1.00 28.20  ? 817  TRP A CD2 1 
ATOM   4088 N  NE1 . TRP A 1 554 ? -20.060 -54.743 -29.811 1.00 30.73  ? 817  TRP A NE1 1 
ATOM   4089 C  CE2 . TRP A 1 554 ? -18.938 -54.194 -30.370 1.00 31.01  ? 817  TRP A CE2 1 
ATOM   4090 C  CE3 . TRP A 1 554 ? -17.965 -53.948 -32.569 1.00 28.80  ? 817  TRP A CE3 1 
ATOM   4091 C  CZ2 . TRP A 1 554 ? -17.871 -53.522 -29.778 1.00 29.86  ? 817  TRP A CZ2 1 
ATOM   4092 C  CZ3 . TRP A 1 554 ? -16.912 -53.285 -31.983 1.00 29.16  ? 817  TRP A CZ3 1 
ATOM   4093 C  CH2 . TRP A 1 554 ? -16.867 -53.077 -30.606 1.00 26.20  ? 817  TRP A CH2 1 
ATOM   4094 N  N   . ILE A 1 555 ? -22.603 -55.026 -36.197 1.00 38.35  ? 818  ILE A N   1 
ATOM   4095 C  CA  . ILE A 1 555 ? -22.756 -55.483 -37.609 1.00 39.05  ? 818  ILE A CA  1 
ATOM   4096 C  C   . ILE A 1 555 ? -23.627 -54.505 -38.403 1.00 42.65  ? 818  ILE A C   1 
ATOM   4097 O  O   . ILE A 1 555 ? -23.085 -53.822 -39.272 1.00 37.10  ? 818  ILE A O   1 
ATOM   4098 C  CB  . ILE A 1 555 ? -23.334 -56.915 -37.655 1.00 42.38  ? 818  ILE A CB  1 
ATOM   4099 C  CG1 . ILE A 1 555 ? -22.570 -57.882 -36.748 1.00 42.61  ? 818  ILE A CG1 1 
ATOM   4100 C  CG2 . ILE A 1 555 ? -23.403 -57.423 -39.086 1.00 42.37  ? 818  ILE A CG2 1 
ATOM   4101 C  CD1 . ILE A 1 555 ? -21.160 -58.161 -37.200 1.00 49.75  ? 818  ILE A CD1 1 
ATOM   4102 N  N   . GLN A 1 556 ? -24.920 -54.428 -38.094 1.00 50.43  ? 819  GLN A N   1 
ATOM   4103 C  CA  . GLN A 1 556 ? -25.878 -53.610 -38.890 1.00 48.16  ? 819  GLN A CA  1 
ATOM   4104 C  C   . GLN A 1 556 ? -25.492 -52.131 -38.949 1.00 41.30  ? 819  GLN A C   1 
ATOM   4105 O  O   . GLN A 1 556 ? -25.382 -51.612 -40.056 1.00 43.02  ? 819  GLN A O   1 
ATOM   4106 C  CB  . GLN A 1 556 ? -27.284 -53.791 -38.314 1.00 51.84  ? 819  GLN A CB  1 
ATOM   4107 C  CG  . GLN A 1 556 ? -28.327 -52.895 -38.961 1.00 63.05  ? 819  GLN A CG  1 
ATOM   4108 C  CD  . GLN A 1 556 ? -29.678 -53.011 -38.301 1.00 69.75  ? 819  GLN A CD  1 
ATOM   4109 O  OE1 . GLN A 1 556 ? -30.492 -52.093 -38.345 1.00 82.60  ? 819  GLN A OE1 1 
ATOM   4110 N  NE2 . GLN A 1 556 ? -29.926 -54.147 -37.671 1.00 71.65  ? 819  GLN A NE2 1 
ATOM   4111 N  N   . GLU A 1 557 ? -25.296 -51.492 -37.805 1.00 39.34  ? 820  GLU A N   1 
ATOM   4112 C  CA  . GLU A 1 557 ? -25.047 -50.035 -37.774 1.00 42.44  ? 820  GLU A CA  1 
ATOM   4113 C  C   . GLU A 1 557 ? -23.541 -49.707 -37.844 1.00 43.88  ? 820  GLU A C   1 
ATOM   4114 O  O   . GLU A 1 557 ? -23.192 -48.510 -37.726 1.00 41.97  ? 820  GLU A O   1 
ATOM   4115 C  CB  . GLU A 1 557 ? -25.668 -49.477 -36.493 1.00 45.96  ? 820  GLU A CB  1 
ATOM   4116 C  CG  . GLU A 1 557 ? -27.185 -49.670 -36.401 1.00 54.82  ? 820  GLU A CG  1 
ATOM   4117 C  CD  . GLU A 1 557 ? -27.799 -48.965 -35.185 1.00 74.16  ? 820  GLU A CD  1 
ATOM   4118 O  OE1 . GLU A 1 557 ? -27.016 -48.675 -34.211 1.00 75.85  ? 820  GLU A OE1 1 
ATOM   4119 O  OE2 . GLU A 1 557 ? -29.058 -48.704 -35.185 1.00 82.00  ? 820  GLU A OE2 1 
ATOM   4120 N  N   . ASN A 1 558 ? -22.673 -50.709 -38.021 1.00 39.53  ? 821  ASN A N   1 
ATOM   4121 C  CA  . ASN A 1 558 ? -21.196 -50.524 -37.984 1.00 39.09  ? 821  ASN A CA  1 
ATOM   4122 C  C   . ASN A 1 558 ? -20.726 -50.156 -39.383 1.00 33.20  ? 821  ASN A C   1 
ATOM   4123 O  O   . ASN A 1 558 ? -20.608 -51.011 -40.240 1.00 35.54  ? 821  ASN A O   1 
ATOM   4124 C  CB  . ASN A 1 558 ? -20.510 -51.770 -37.413 1.00 38.24  ? 821  ASN A CB  1 
ATOM   4125 C  CG  . ASN A 1 558 ? -18.992 -51.740 -37.413 1.00 36.28  ? 821  ASN A CG  1 
ATOM   4126 O  OD1 . ASN A 1 558 ? -18.382 -50.833 -37.965 1.00 34.06  ? 821  ASN A OD1 1 
ATOM   4127 N  ND2 . ASN A 1 558 ? -18.382 -52.791 -36.868 1.00 34.04  ? 821  ASN A ND2 1 
ATOM   4128 N  N   . PRO A 1 559 ? -20.356 -48.897 -39.656 1.00 37.27  ? 822  PRO A N   1 
ATOM   4129 C  CA  . PRO A 1 559 ? -19.935 -48.520 -40.999 1.00 40.05  ? 822  PRO A CA  1 
ATOM   4130 C  C   . PRO A 1 559 ? -18.613 -49.143 -41.443 1.00 40.87  ? 822  PRO A C   1 
ATOM   4131 O  O   . PRO A 1 559 ? -18.287 -49.043 -42.581 1.00 46.90  ? 822  PRO A O   1 
ATOM   4132 C  CB  . PRO A 1 559 ? -19.798 -46.990 -40.900 1.00 42.92  ? 822  PRO A CB  1 
ATOM   4133 C  CG  . PRO A 1 559 ? -19.471 -46.780 -39.443 1.00 40.26  ? 822  PRO A CG  1 
ATOM   4134 C  CD  . PRO A 1 559 ? -20.388 -47.750 -38.738 1.00 38.15  ? 822  PRO A CD  1 
ATOM   4135 N  N   . TRP A 1 560 ? -17.861 -49.762 -40.549 1.00 40.54  ? 823  TRP A N   1 
ATOM   4136 C  CA  . TRP A 1 560 ? -16.608 -50.442 -40.961 1.00 41.73  ? 823  TRP A CA  1 
ATOM   4137 C  C   . TRP A 1 560 ? -16.816 -51.925 -41.313 1.00 40.60  ? 823  TRP A C   1 
ATOM   4138 O  O   . TRP A 1 560 ? -15.828 -52.536 -41.683 1.00 47.66  ? 823  TRP A O   1 
ATOM   4139 C  CB  . TRP A 1 560 ? -15.584 -50.243 -39.855 1.00 40.82  ? 823  TRP A CB  1 
ATOM   4140 C  CG  . TRP A 1 560 ? -15.119 -48.823 -39.755 1.00 37.46  ? 823  TRP A CG  1 
ATOM   4141 C  CD1 . TRP A 1 560 ? -14.152 -48.200 -40.498 1.00 31.42  ? 823  TRP A CD1 1 
ATOM   4142 C  CD2 . TRP A 1 560 ? -15.610 -47.849 -38.822 1.00 34.49  ? 823  TRP A CD2 1 
ATOM   4143 N  NE1 . TRP A 1 560 ? -14.023 -46.894 -40.087 1.00 34.59  ? 823  TRP A NE1 1 
ATOM   4144 C  CE2 . TRP A 1 560 ? -14.885 -46.663 -39.041 1.00 34.91  ? 823  TRP A CE2 1 
ATOM   4145 C  CE3 . TRP A 1 560 ? -16.518 -47.901 -37.770 1.00 35.55  ? 823  TRP A CE3 1 
ATOM   4146 C  CZ2 . TRP A 1 560 ? -15.081 -45.527 -38.264 1.00 36.15  ? 823  TRP A CZ2 1 
ATOM   4147 C  CZ3 . TRP A 1 560 ? -16.754 -46.763 -37.042 1.00 35.64  ? 823  TRP A CZ3 1 
ATOM   4148 C  CH2 . TRP A 1 560 ? -16.029 -45.596 -37.271 1.00 35.81  ? 823  TRP A CH2 1 
ATOM   4149 N  N   . MET A 1 561 ? -18.035 -52.471 -41.213 1.00 44.79  ? 824  MET A N   1 
ATOM   4150 C  CA  . MET A 1 561 ? -18.394 -53.895 -41.544 1.00 44.96  ? 824  MET A CA  1 
ATOM   4151 C  C   . MET A 1 561 ? -19.204 -53.904 -42.849 1.00 45.55  ? 824  MET A C   1 
ATOM   4152 O  O   . MET A 1 561 ? -20.365 -53.399 -42.822 1.00 40.92  ? 824  MET A O   1 
ATOM   4153 C  CB  . MET A 1 561 ? -19.249 -54.485 -40.421 1.00 44.18  ? 824  MET A CB  1 
ATOM   4154 C  CG  . MET A 1 561 ? -19.416 -55.990 -40.424 1.00 51.54  ? 824  MET A CG  1 
ATOM   4155 S  SD  . MET A 1 561 ? -17.900 -56.768 -39.883 1.00 71.97  ? 824  MET A SD  1 
ATOM   4156 C  CE  . MET A 1 561 ? -17.951 -56.524 -38.107 1.00 67.33  ? 824  MET A CE  1 
ATOM   4157 N  N   . GLU A 1 562 ? -18.624 -54.386 -43.957 1.00 49.04  ? 825  GLU A N   1 
ATOM   4158 C  CA  . GLU A 1 562 ? -19.310 -54.459 -45.287 1.00 55.13  ? 825  GLU A CA  1 
ATOM   4159 C  C   . GLU A 1 562 ? -20.358 -55.590 -45.296 1.00 52.80  ? 825  GLU A C   1 
ATOM   4160 O  O   . GLU A 1 562 ? -21.437 -55.322 -45.768 1.00 50.25  ? 825  GLU A O   1 
ATOM   4161 C  CB  . GLU A 1 562 ? -18.331 -54.650 -46.444 1.00 60.32  ? 825  GLU A CB  1 
ATOM   4162 C  CG  . GLU A 1 562 ? -18.937 -54.418 -47.820 1.00 75.78  ? 825  GLU A CG  1 
ATOM   4163 C  CD  . GLU A 1 562 ? -17.958 -54.171 -48.974 1.00 95.83  ? 825  GLU A CD  1 
ATOM   4164 O  OE1 . GLU A 1 562 ? -18.387 -54.315 -50.152 1.00 98.82  ? 825  GLU A OE1 1 
ATOM   4165 O  OE2 . GLU A 1 562 ? -16.771 -53.809 -48.715 1.00 99.59  ? 825  GLU A OE2 1 
ATOM   4166 N  N   . ASP A 1 563 ? -20.041 -56.793 -44.807 1.00 50.12  ? 826  ASP A N   1 
ATOM   4167 C  CA  . ASP A 1 563 ? -20.958 -57.965 -44.796 1.00 48.87  ? 826  ASP A CA  1 
ATOM   4168 C  C   . ASP A 1 563 ? -21.896 -57.875 -43.585 1.00 48.22  ? 826  ASP A C   1 
ATOM   4169 O  O   . ASP A 1 563 ? -21.378 -57.839 -42.462 1.00 47.23  ? 826  ASP A O   1 
ATOM   4170 C  CB  . ASP A 1 563 ? -20.138 -59.257 -44.783 1.00 51.73  ? 826  ASP A CB  1 
ATOM   4171 C  CG  . ASP A 1 563 ? -20.954 -60.485 -44.413 1.00 51.95  ? 826  ASP A CG  1 
ATOM   4172 O  OD1 . ASP A 1 563 ? -22.186 -60.360 -44.316 1.00 46.34  ? 826  ASP A OD1 1 
ATOM   4173 O  OD2 . ASP A 1 563 ? -20.343 -61.526 -44.141 1.00 55.73  ? 826  ASP A OD2 1 
ATOM   4174 N  N   . LYS A 1 564 ? -23.221 -57.851 -43.793 1.00 46.03  ? 827  LYS A N   1 
ATOM   4175 C  CA  . LYS A 1 564 ? -24.206 -57.523 -42.722 1.00 44.15  ? 827  LYS A CA  1 
ATOM   4176 C  C   . LYS A 1 564 ? -24.897 -58.784 -42.202 1.00 39.40  ? 827  LYS A C   1 
ATOM   4177 O  O   . LYS A 1 564 ? -25.951 -58.652 -41.510 1.00 41.76  ? 827  LYS A O   1 
ATOM   4178 C  CB  . LYS A 1 564 ? -25.242 -56.494 -43.190 1.00 48.21  ? 827  LYS A CB  1 
ATOM   4179 C  CG  . LYS A 1 564 ? -24.649 -55.164 -43.636 1.00 47.50  ? 827  LYS A CG  1 
ATOM   4180 C  CD  . LYS A 1 564 ? -23.923 -54.453 -42.558 1.00 45.30  ? 827  LYS A CD  1 
ATOM   4181 C  CE  . LYS A 1 564 ? -23.676 -53.003 -42.872 1.00 46.86  ? 827  LYS A CE  1 
ATOM   4182 N  NZ  . LYS A 1 564 ? -23.011 -52.309 -41.745 1.00 48.61  ? 827  LYS A NZ  1 
ATOM   4183 N  N   . THR A 1 565 ? -24.317 -59.952 -42.464 1.00 41.42  ? 828  THR A N   1 
ATOM   4184 C  CA  . THR A 1 565 ? -24.887 -61.261 -42.026 1.00 45.78  ? 828  THR A CA  1 
ATOM   4185 C  C   . THR A 1 565 ? -25.042 -61.240 -40.510 1.00 45.11  ? 828  THR A C   1 
ATOM   4186 O  O   . THR A 1 565 ? -24.034 -61.135 -39.803 1.00 41.45  ? 828  THR A O   1 
ATOM   4187 C  CB  . THR A 1 565 ? -23.974 -62.426 -42.433 1.00 51.18  ? 828  THR A CB  1 
ATOM   4188 O  OG1 . THR A 1 565 ? -23.826 -62.406 -43.851 1.00 57.22  ? 828  THR A OG1 1 
ATOM   4189 C  CG2 . THR A 1 565 ? -24.505 -63.775 -42.012 1.00 55.35  ? 828  THR A CG2 1 
ATOM   4190 N  N   . PRO A 1 566 ? -26.261 -61.373 -39.936 1.00 47.11  ? 829  PRO A N   1 
ATOM   4191 C  CA  . PRO A 1 566 ? -26.382 -61.333 -38.485 1.00 49.91  ? 829  PRO A CA  1 
ATOM   4192 C  C   . PRO A 1 566 ? -25.633 -62.531 -37.880 1.00 51.23  ? 829  PRO A C   1 
ATOM   4193 O  O   . PRO A 1 566 ? -25.417 -63.523 -38.535 1.00 53.08  ? 829  PRO A O   1 
ATOM   4194 C  CB  . PRO A 1 566 ? -27.897 -61.322 -38.197 1.00 50.40  ? 829  PRO A CB  1 
ATOM   4195 C  CG  . PRO A 1 566 ? -28.572 -61.174 -39.552 1.00 49.79  ? 829  PRO A CG  1 
ATOM   4196 C  CD  . PRO A 1 566 ? -27.551 -61.619 -40.589 1.00 48.10  ? 829  PRO A CD  1 
ATOM   4197 N  N   . VAL A 1 567 ? -25.214 -62.383 -36.624 0.40 52.22  ? 830  VAL A N   1 
ATOM   4198 C  CA  . VAL A 1 567 ? -24.643 -63.482 -35.791 0.40 52.80  ? 830  VAL A CA  1 
ATOM   4199 C  C   . VAL A 1 567 ? -25.823 -64.203 -35.123 0.40 53.16  ? 830  VAL A C   1 
ATOM   4200 O  O   . VAL A 1 567 ? -26.755 -63.510 -34.650 0.40 51.97  ? 830  VAL A O   1 
ATOM   4201 C  CB  . VAL A 1 567 ? -23.610 -62.932 -34.785 0.40 53.81  ? 830  VAL A CB  1 
ATOM   4202 C  CG1 . VAL A 1 567 ? -23.505 -63.779 -33.531 0.40 54.86  ? 830  VAL A CG1 1 
ATOM   4203 C  CG2 . VAL A 1 567 ? -22.240 -62.761 -35.426 0.40 52.50  ? 830  VAL A CG2 1 
ATOM   4204 N  N   . GLU A 1 568 ? -25.795 -65.539 -35.108 1.00 54.49  ? 831  GLU A N   1 
ATOM   4205 C  CA  . GLU A 1 568 ? -26.956 -66.381 -34.664 1.00 59.77  ? 831  GLU A CA  1 
ATOM   4206 C  C   . GLU A 1 568 ? -26.836 -66.773 -33.186 1.00 56.25  ? 831  GLU A C   1 
ATOM   4207 O  O   . GLU A 1 568 ? -27.886 -66.998 -32.588 1.00 51.27  ? 831  GLU A O   1 
ATOM   4208 C  CB  . GLU A 1 568 ? -27.103 -67.612 -35.578 1.00 63.31  ? 831  GLU A CB  1 
ATOM   4209 C  CG  . GLU A 1 568 ? -27.615 -67.279 -36.987 1.00 65.03  ? 831  GLU A CG  1 
ATOM   4210 C  CD  . GLU A 1 568 ? -28.984 -66.600 -36.997 1.00 70.63  ? 831  GLU A CD  1 
ATOM   4211 O  OE1 . GLU A 1 568 ? -29.745 -66.802 -36.038 1.00 75.09  ? 831  GLU A OE1 1 
ATOM   4212 O  OE2 . GLU A 1 568 ? -29.289 -65.859 -37.946 1.00 73.89  ? 831  GLU A OE2 1 
ATOM   4213 N  N   . SER A 1 569 ? -25.623 -66.857 -32.619 1.00 46.31  ? 832  SER A N   1 
ATOM   4214 C  CA  . SER A 1 569 ? -25.414 -67.135 -31.174 1.00 45.03  ? 832  SER A CA  1 
ATOM   4215 C  C   . SER A 1 569 ? -24.143 -66.483 -30.626 1.00 46.15  ? 832  SER A C   1 
ATOM   4216 O  O   . SER A 1 569 ? -23.222 -66.073 -31.403 1.00 39.62  ? 832  SER A O   1 
ATOM   4217 C  CB  . SER A 1 569 ? -25.322 -68.592 -30.918 1.00 43.51  ? 832  SER A CB  1 
ATOM   4218 O  OG  . SER A 1 569 ? -24.114 -69.060 -31.433 1.00 42.10  ? 832  SER A OG  1 
ATOM   4219 N  N   . TRP A 1 570 ? -24.048 -66.501 -29.306 1.00 40.00  ? 833  TRP A N   1 
ATOM   4220 C  CA  . TRP A 1 570 ? -22.876 -65.942 -28.601 1.00 45.11  ? 833  TRP A CA  1 
ATOM   4221 C  C   . TRP A 1 570 ? -21.570 -66.688 -28.960 1.00 43.80  ? 833  TRP A C   1 
ATOM   4222 O  O   . TRP A 1 570 ? -20.537 -66.080 -28.973 1.00 38.50  ? 833  TRP A O   1 
ATOM   4223 C  CB  . TRP A 1 570 ? -23.178 -65.864 -27.111 1.00 40.06  ? 833  TRP A CB  1 
ATOM   4224 C  CG  . TRP A 1 570 ? -24.028 -64.685 -26.763 1.00 42.68  ? 833  TRP A CG  1 
ATOM   4225 C  CD1 . TRP A 1 570 ? -25.368 -64.702 -26.507 1.00 40.84  ? 833  TRP A CD1 1 
ATOM   4226 C  CD2 . TRP A 1 570 ? -23.613 -63.300 -26.655 1.00 43.75  ? 833  TRP A CD2 1 
ATOM   4227 N  NE1 . TRP A 1 570 ? -25.806 -63.437 -26.216 1.00 44.51  ? 833  TRP A NE1 1 
ATOM   4228 C  CE2 . TRP A 1 570 ? -24.761 -62.553 -26.307 1.00 40.59  ? 833  TRP A CE2 1 
ATOM   4229 C  CE3 . TRP A 1 570 ? -22.395 -62.615 -26.808 1.00 42.18  ? 833  TRP A CE3 1 
ATOM   4230 C  CZ2 . TRP A 1 570 ? -24.719 -61.175 -26.076 1.00 42.63  ? 833  TRP A CZ2 1 
ATOM   4231 C  CZ3 . TRP A 1 570 ? -22.358 -61.256 -26.586 1.00 43.45  ? 833  TRP A CZ3 1 
ATOM   4232 C  CH2 . TRP A 1 570 ? -23.509 -60.541 -26.238 1.00 43.13  ? 833  TRP A CH2 1 
ATOM   4233 N  N   . GLU A 1 571 ? -21.625 -67.983 -29.273 0.40 43.20  ? 834  GLU A N   1 
ATOM   4234 C  CA  . GLU A 1 571 ? -20.394 -68.784 -29.537 0.40 45.22  ? 834  GLU A CA  1 
ATOM   4235 C  C   . GLU A 1 571 ? -19.751 -68.380 -30.876 0.40 43.36  ? 834  GLU A C   1 
ATOM   4236 O  O   . GLU A 1 571 ? -18.574 -68.701 -31.062 0.40 44.23  ? 834  GLU A O   1 
ATOM   4237 C  CB  . GLU A 1 571 ? -20.695 -70.283 -29.471 0.40 48.59  ? 834  GLU A CB  1 
ATOM   4238 C  CG  . GLU A 1 571 ? -20.756 -70.814 -28.048 0.40 50.23  ? 834  GLU A CG  1 
ATOM   4239 C  CD  . GLU A 1 571 ? -21.161 -72.274 -27.924 0.40 53.47  ? 834  GLU A CD  1 
ATOM   4240 O  OE1 . GLU A 1 571 ? -20.718 -73.093 -28.761 0.40 55.74  ? 834  GLU A OE1 1 
ATOM   4241 O  OE2 . GLU A 1 571 ? -21.934 -72.587 -26.995 0.40 57.72  ? 834  GLU A OE2 1 
ATOM   4242 N  N   . GLU A 1 572 ? -20.478 -67.709 -31.775 0.40 45.24  ? 835  GLU A N   1 
ATOM   4243 C  CA  . GLU A 1 572 ? -19.911 -67.103 -33.016 0.40 46.64  ? 835  GLU A CA  1 
ATOM   4244 C  C   . GLU A 1 572 ? -19.016 -65.902 -32.672 0.40 44.37  ? 835  GLU A C   1 
ATOM   4245 O  O   . GLU A 1 572 ? -18.208 -65.509 -33.538 0.40 42.72  ? 835  GLU A O   1 
ATOM   4246 C  CB  . GLU A 1 572 ? -21.002 -66.575 -33.951 0.40 48.85  ? 835  GLU A CB  1 
ATOM   4247 C  CG  . GLU A 1 572 ? -21.693 -67.629 -34.789 0.40 53.09  ? 835  GLU A CG  1 
ATOM   4248 C  CD  . GLU A 1 572 ? -22.298 -67.051 -36.061 0.40 54.54  ? 835  GLU A CD  1 
ATOM   4249 O  OE1 . GLU A 1 572 ? -21.510 -66.698 -36.969 0.40 54.54  ? 835  GLU A OE1 1 
ATOM   4250 O  OE2 . GLU A 1 572 ? -23.547 -66.921 -36.130 0.40 51.54  ? 835  GLU A OE2 1 
ATOM   4251 N  N   . ILE A 1 573 ? -19.204 -65.307 -31.488 1.00 41.17  ? 836  ILE A N   1 
ATOM   4252 C  CA  . ILE A 1 573 ? -18.518 -64.044 -31.073 1.00 41.30  ? 836  ILE A CA  1 
ATOM   4253 C  C   . ILE A 1 573 ? -17.230 -64.411 -30.334 1.00 38.09  ? 836  ILE A C   1 
ATOM   4254 O  O   . ILE A 1 573 ? -17.226 -65.057 -29.278 1.00 35.38  ? 836  ILE A O   1 
ATOM   4255 C  CB  . ILE A 1 573 ? -19.472 -63.159 -30.258 1.00 39.47  ? 836  ILE A CB  1 
ATOM   4256 C  CG1 . ILE A 1 573 ? -20.666 -62.715 -31.100 1.00 37.86  ? 836  ILE A CG1 1 
ATOM   4257 C  CG2 . ILE A 1 573 ? -18.738 -61.967 -29.673 1.00 43.76  ? 836  ILE A CG2 1 
ATOM   4258 C  CD1 . ILE A 1 573 ? -21.804 -62.143 -30.279 1.00 36.89  ? 836  ILE A CD1 1 
ATOM   4259 N  N   . PRO A 1 574 ? -16.087 -63.961 -30.877 1.00 34.44  ? 837  PRO A N   1 
ATOM   4260 C  CA  . PRO A 1 574 ? -14.782 -64.427 -30.424 1.00 35.27  ? 837  PRO A CA  1 
ATOM   4261 C  C   . PRO A 1 574 ? -14.292 -63.759 -29.147 1.00 32.36  ? 837  PRO A C   1 
ATOM   4262 O  O   . PRO A 1 574 ? -14.837 -62.765 -28.717 1.00 31.58  ? 837  PRO A O   1 
ATOM   4263 C  CB  . PRO A 1 574 ? -13.831 -64.023 -31.551 1.00 36.11  ? 837  PRO A CB  1 
ATOM   4264 C  CG  . PRO A 1 574 ? -14.503 -62.800 -32.169 1.00 40.75  ? 837  PRO A CG  1 
ATOM   4265 C  CD  . PRO A 1 574 ? -15.996 -62.930 -31.913 1.00 39.08  ? 837  PRO A CD  1 
ATOM   4266 N  N   . TYR A 1 575 ? -13.252 -64.342 -28.551 0.40 33.38  ? 838  TYR A N   1 
ATOM   4267 C  CA  . TYR A 1 575 ? -12.492 -63.766 -27.412 0.40 33.57  ? 838  TYR A CA  1 
ATOM   4268 C  C   . TYR A 1 575 ? -11.105 -63.320 -27.900 0.40 33.02  ? 838  TYR A C   1 
ATOM   4269 O  O   . TYR A 1 575 ? -10.631 -63.804 -28.957 0.40 31.87  ? 838  TYR A O   1 
ATOM   4270 C  CB  . TYR A 1 575 ? -12.334 -64.797 -26.294 0.40 33.72  ? 838  TYR A CB  1 
ATOM   4271 C  CG  . TYR A 1 575 ? -13.610 -65.317 -25.681 0.40 34.43  ? 838  TYR A CG  1 
ATOM   4272 C  CD1 . TYR A 1 575 ? -14.246 -64.631 -24.659 0.40 34.25  ? 838  TYR A CD1 1 
ATOM   4273 C  CD2 . TYR A 1 575 ? -14.156 -66.524 -26.087 0.40 34.05  ? 838  TYR A CD2 1 
ATOM   4274 C  CE1 . TYR A 1 575 ? -15.395 -65.124 -24.063 0.40 35.18  ? 838  TYR A CE1 1 
ATOM   4275 C  CE2 . TYR A 1 575 ? -15.301 -67.035 -25.500 0.40 35.04  ? 838  TYR A CE2 1 
ATOM   4276 C  CZ  . TYR A 1 575 ? -15.929 -66.328 -24.491 0.40 36.00  ? 838  TYR A CZ  1 
ATOM   4277 O  OH  . TYR A 1 575 ? -17.070 -66.816 -23.927 0.40 36.49  ? 838  TYR A OH  1 
ATOM   4278 N  N   . LEU A 1 576 ? -10.453 -62.438 -27.137 0.40 30.96  ? 839  LEU A N   1 
ATOM   4279 C  CA  . LEU A 1 576 ? -8.998  -62.174 -27.269 0.40 31.34  ? 839  LEU A CA  1 
ATOM   4280 C  C   . LEU A 1 576 ? -8.247  -63.501 -27.079 0.40 31.05  ? 839  LEU A C   1 
ATOM   4281 O  O   . LEU A 1 576 ? -8.785  -64.414 -26.394 0.40 31.18  ? 839  LEU A O   1 
ATOM   4282 C  CB  . LEU A 1 576 ? -8.535  -61.180 -26.199 0.40 31.96  ? 839  LEU A CB  1 
ATOM   4283 C  CG  . LEU A 1 576 ? -9.171  -59.791 -26.222 0.40 31.94  ? 839  LEU A CG  1 
ATOM   4284 C  CD1 . LEU A 1 576 ? -8.675  -58.971 -25.045 0.40 32.61  ? 839  LEU A CD1 1 
ATOM   4285 C  CD2 . LEU A 1 576 ? -8.884  -59.070 -27.531 0.40 31.83  ? 839  LEU A CD2 1 
ATOM   4286 N  N   . GLY A 1 577 ? -7.030  -63.592 -27.622 0.40 30.33  ? 840  GLY A N   1 
ATOM   4287 C  CA  . GLY A 1 577 ? -6.080  -64.679 -27.305 0.40 29.65  ? 840  GLY A CA  1 
ATOM   4288 C  C   . GLY A 1 577 ? -5.921  -64.863 -25.785 0.40 27.80  ? 840  GLY A C   1 
ATOM   4289 O  O   . GLY A 1 577 ? -5.865  -63.839 -25.019 0.40 27.96  ? 840  GLY A O   1 
ATOM   4290 N  N   . LYS A 1 578 ? -5.926  -66.147 -25.368 0.40 27.41  ? 841  LYS A N   1 
ATOM   4291 C  CA  . LYS A 1 578 ? -5.830  -66.570 -23.948 0.40 29.53  ? 841  LYS A CA  1 
ATOM   4292 C  C   . LYS A 1 578 ? -4.693  -65.825 -23.237 0.40 30.13  ? 841  LYS A C   1 
ATOM   4293 O  O   . LYS A 1 578 ? -4.860  -65.458 -22.059 0.40 31.21  ? 841  LYS A O   1 
ATOM   4294 C  CB  . LYS A 1 578 ? -5.595  -68.078 -23.901 0.40 29.50  ? 841  LYS A CB  1 
ATOM   4295 C  CG  . LYS A 1 578 ? -6.863  -68.913 -23.995 0.40 28.73  ? 841  LYS A CG  1 
ATOM   4296 C  CD  . LYS A 1 578 ? -6.663  -70.268 -24.621 0.40 29.77  ? 841  LYS A CD  1 
ATOM   4297 C  CE  . LYS A 1 578 ? -5.431  -71.003 -24.153 0.40 27.75  ? 841  LYS A CE  1 
ATOM   4298 N  NZ  . LYS A 1 578 ? -5.145  -72.140 -25.052 0.40 28.89  ? 841  LYS A NZ  1 
ATOM   4299 N  N   . ARG A 1 579 ? -3.575  -65.618 -23.929 1.00 29.57  ? 842  ARG A N   1 
ATOM   4300 C  CA  . ARG A 1 579 ? -2.411  -64.909 -23.356 1.00 31.33  ? 842  ARG A CA  1 
ATOM   4301 C  C   . ARG A 1 579 ? -2.692  -63.401 -23.359 1.00 28.05  ? 842  ARG A C   1 
ATOM   4302 O  O   . ARG A 1 579 ? -2.368  -62.734 -22.336 1.00 30.81  ? 842  ARG A O   1 
ATOM   4303 C  CB  . ARG A 1 579 ? -1.097  -65.338 -24.018 1.00 28.75  ? 842  ARG A CB  1 
ATOM   4304 C  CG  . ARG A 1 579 ? 0.124   -64.719 -23.361 1.00 31.40  ? 842  ARG A CG  1 
ATOM   4305 C  CD  . ARG A 1 579 ? 1.467   -65.093 -24.003 1.00 35.95  ? 842  ARG A CD  1 
ATOM   4306 N  NE  . ARG A 1 579 ? 1.458   -66.535 -24.166 1.00 39.85  ? 842  ARG A NE  1 
ATOM   4307 C  CZ  . ARG A 1 579 ? 1.640   -67.383 -23.184 1.00 40.49  ? 842  ARG A CZ  1 
ATOM   4308 N  NH1 . ARG A 1 579 ? 1.437   -68.673 -23.390 1.00 49.15  ? 842  ARG A NH1 1 
ATOM   4309 N  NH2 . ARG A 1 579 ? 2.015   -66.936 -22.004 1.00 43.81  ? 842  ARG A NH2 1 
ATOM   4310 N  N   . GLU A 1 580 ? -3.243  -62.858 -24.440 1.00 30.59  ? 843  GLU A N   1 
ATOM   4311 C  CA  . GLU A 1 580 ? -3.690  -61.435 -24.469 1.00 31.12  ? 843  GLU A CA  1 
ATOM   4312 C  C   . GLU A 1 580 ? -4.683  -61.181 -23.335 1.00 26.90  ? 843  GLU A C   1 
ATOM   4313 O  O   . GLU A 1 580 ? -4.540  -60.195 -22.659 1.00 26.46  ? 843  GLU A O   1 
ATOM   4314 C  CB  . GLU A 1 580 ? -4.408  -61.068 -25.748 1.00 33.76  ? 843  GLU A CB  1 
ATOM   4315 C  CG  . GLU A 1 580 ? -3.601  -61.339 -26.958 1.00 36.85  ? 843  GLU A CG  1 
ATOM   4316 C  CD  . GLU A 1 580 ? -4.301  -60.835 -28.206 1.00 45.96  ? 843  GLU A CD  1 
ATOM   4317 O  OE1 . GLU A 1 580 ? -5.308  -61.477 -28.651 1.00 43.65  ? 843  GLU A OE1 1 
ATOM   4318 O  OE2 . GLU A 1 580 ? -3.822  -59.815 -28.739 1.00 53.80  ? 843  GLU A OE2 1 
ATOM   4319 N  N   . ASP A 1 581 ? -5.608  -62.103 -23.092 1.00 28.47  ? 844  ASP A N   1 
ATOM   4320 C  CA  . ASP A 1 581 ? -6.619  -61.973 -22.028 1.00 30.23  ? 844  ASP A CA  1 
ATOM   4321 C  C   . ASP A 1 581 ? -5.915  -61.832 -20.683 1.00 28.22  ? 844  ASP A C   1 
ATOM   4322 O  O   . ASP A 1 581 ? -6.301  -60.919 -19.878 1.00 28.06  ? 844  ASP A O   1 
ATOM   4323 C  CB  . ASP A 1 581 ? -7.664  -63.088 -22.111 1.00 31.18  ? 844  ASP A CB  1 
ATOM   4324 C  CG  . ASP A 1 581 ? -9.065  -62.750 -21.586 1.00 30.85  ? 844  ASP A CG  1 
ATOM   4325 O  OD1 . ASP A 1 581 ? -9.247  -61.717 -20.886 1.00 27.16  ? 844  ASP A OD1 1 
ATOM   4326 O  OD2 . ASP A 1 581 ? -9.976  -63.569 -21.861 1.00 32.43  ? 844  ASP A OD2 1 
ATOM   4327 N  N   . GLN A 1 582 ? -4.928  -62.694 -20.413 0.40 27.17  ? 845  GLN A N   1 
ATOM   4328 C  CA  . GLN A 1 582 ? -4.127  -62.675 -19.156 0.40 27.34  ? 845  GLN A CA  1 
ATOM   4329 C  C   . GLN A 1 582 ? -3.386  -61.339 -19.041 0.40 26.60  ? 845  GLN A C   1 
ATOM   4330 O  O   . GLN A 1 582 ? -3.468  -60.702 -17.963 0.40 26.93  ? 845  GLN A O   1 
ATOM   4331 C  CB  . GLN A 1 582 ? -3.112  -63.826 -19.109 0.40 28.07  ? 845  GLN A CB  1 
ATOM   4332 C  CG  . GLN A 1 582 ? -3.706  -65.168 -18.707 0.40 28.81  ? 845  GLN A CG  1 
ATOM   4333 C  CD  . GLN A 1 582 ? -2.620  -66.183 -18.411 0.40 28.44  ? 845  GLN A CD  1 
ATOM   4334 O  OE1 . GLN A 1 582 ? -1.491  -66.055 -18.875 0.40 26.72  ? 845  GLN A OE1 1 
ATOM   4335 N  NE2 . GLN A 1 582 ? -2.949  -67.200 -17.628 0.40 27.47  ? 845  GLN A NE2 1 
ATOM   4336 N  N   . TRP A 1 583 ? -2.691  -60.931 -20.111 1.00 25.43  ? 846  TRP A N   1 
ATOM   4337 C  CA  . TRP A 1 583 ? -1.953  -59.643 -20.151 1.00 26.79  ? 846  TRP A CA  1 
ATOM   4338 C  C   . TRP A 1 583 ? -2.865  -58.479 -19.720 1.00 30.93  ? 846  TRP A C   1 
ATOM   4339 O  O   . TRP A 1 583 ? -2.356  -57.569 -18.993 1.00 27.79  ? 846  TRP A O   1 
ATOM   4340 C  CB  . TRP A 1 583 ? -1.381  -59.377 -21.544 1.00 28.55  ? 846  TRP A CB  1 
ATOM   4341 C  CG  . TRP A 1 583 ? -0.187  -60.216 -21.900 1.00 29.58  ? 846  TRP A CG  1 
ATOM   4342 C  CD1 . TRP A 1 583 ? 0.610   -60.906 -21.048 1.00 29.44  ? 846  TRP A CD1 1 
ATOM   4343 C  CD2 . TRP A 1 583 ? 0.300   -60.487 -23.218 1.00 28.31  ? 846  TRP A CD2 1 
ATOM   4344 N  NE1 . TRP A 1 583 ? 1.569   -61.590 -21.751 1.00 33.19  ? 846  TRP A NE1 1 
ATOM   4345 C  CE2 . TRP A 1 583 ? 1.405   -61.343 -23.088 1.00 30.98  ? 846  TRP A CE2 1 
ATOM   4346 C  CE3 . TRP A 1 583 ? -0.082  -60.091 -24.495 1.00 34.06  ? 846  TRP A CE3 1 
ATOM   4347 C  CZ2 . TRP A 1 583 ? 2.136   -61.796 -24.192 1.00 31.95  ? 846  TRP A CZ2 1 
ATOM   4348 C  CZ3 . TRP A 1 583 ? 0.616   -60.556 -25.596 1.00 36.36  ? 846  TRP A CZ3 1 
ATOM   4349 C  CH2 . TRP A 1 583 ? 1.745   -61.366 -25.436 1.00 34.50  ? 846  TRP A CH2 1 
ATOM   4350 N  N   . CYS A 1 584 ? -4.158  -58.517 -20.087 1.00 28.49  ? 847  CYS A N   1 
ATOM   4351 C  CA  . CYS A 1 584 ? -5.107  -57.422 -19.758 1.00 27.69  ? 847  CYS A CA  1 
ATOM   4352 C  C   . CYS A 1 584 ? -5.861  -57.761 -18.467 1.00 28.64  ? 847  CYS A C   1 
ATOM   4353 O  O   . CYS A 1 584 ? -6.893  -57.140 -18.234 1.00 27.74  ? 847  CYS A O   1 
ATOM   4354 C  CB  . CYS A 1 584 ? -5.987  -57.081 -20.946 1.00 29.22  ? 847  CYS A CB  1 
ATOM   4355 S  SG  . CYS A 1 584 ? -4.994  -56.378 -22.274 1.00 32.65  ? 847  CYS A SG  1 
ATOM   4356 N  N   . GLY A 1 585 ? -5.308  -58.681 -17.656 1.00 30.52  ? 848  GLY A N   1 
ATOM   4357 C  CA  . GLY A 1 585 ? -5.709  -58.904 -16.253 1.00 27.57  ? 848  GLY A CA  1 
ATOM   4358 C  C   . GLY A 1 585 ? -6.651  -60.078 -16.030 1.00 28.18  ? 848  GLY A C   1 
ATOM   4359 O  O   . GLY A 1 585 ? -7.101  -60.239 -14.882 1.00 33.17  ? 848  GLY A O   1 
ATOM   4360 N  N   . SER A 1 586 ? -6.844  -60.971 -17.005 1.00 25.87  ? 849  SER A N   1 
ATOM   4361 C  CA  . SER A 1 586 ? -7.688  -62.181 -16.799 1.00 27.08  ? 849  SER A CA  1 
ATOM   4362 C  C   . SER A 1 586 ? -7.134  -63.119 -15.728 1.00 32.62  ? 849  SER A C   1 
ATOM   4363 O  O   . SER A 1 586 ? -5.912  -63.246 -15.647 1.00 28.74  ? 849  SER A O   1 
ATOM   4364 C  CB  . SER A 1 586 ? -7.917  -62.965 -18.065 1.00 27.99  ? 849  SER A CB  1 
ATOM   4365 O  OG  . SER A 1 586 ? -8.744  -64.088 -17.825 1.00 27.53  ? 849  SER A OG  1 
ATOM   4366 N  N   . LEU A 1 587 ? -8.028  -63.793 -15.001 1.00 30.94  ? 850  LEU A N   1 
ATOM   4367 C  CA  . LEU A 1 587 ? -7.656  -64.761 -13.935 1.00 30.14  ? 850  LEU A CA  1 
ATOM   4368 C  C   . LEU A 1 587 ? -7.679  -66.184 -14.504 1.00 31.12  ? 850  LEU A C   1 
ATOM   4369 O  O   . LEU A 1 587 ? -7.507  -67.116 -13.725 1.00 32.47  ? 850  LEU A O   1 
ATOM   4370 C  CB  . LEU A 1 587 ? -8.661  -64.627 -12.789 1.00 29.68  ? 850  LEU A CB  1 
ATOM   4371 C  CG  . LEU A 1 587 ? -8.636  -63.309 -12.019 1.00 32.19  ? 850  LEU A CG  1 
ATOM   4372 C  CD1 . LEU A 1 587 ? -9.325  -63.466 -10.676 1.00 32.30  ? 850  LEU A CD1 1 
ATOM   4373 C  CD2 . LEU A 1 587 ? -7.210  -62.823 -11.822 1.00 34.49  ? 850  LEU A CD2 1 
ATOM   4374 N  N   . ILE A 1 588 ? -7.900  -66.330 -15.813 0.40 28.27  ? 851  ILE A N   1 
ATOM   4375 C  CA  . ILE A 1 588 ? -7.839  -67.686 -16.432 0.40 30.04  ? 851  ILE A CA  1 
ATOM   4376 C  C   . ILE A 1 588 ? -6.487  -68.308 -16.071 0.40 31.93  ? 851  ILE A C   1 
ATOM   4377 O  O   . ILE A 1 588 ? -5.473  -67.607 -16.190 0.40 31.33  ? 851  ILE A O   1 
ATOM   4378 C  CB  . ILE A 1 588 ? -8.084  -67.644 -17.956 0.40 28.21  ? 851  ILE A CB  1 
ATOM   4379 C  CG1 . ILE A 1 588 ? -7.084  -66.744 -18.684 0.40 28.46  ? 851  ILE A CG1 1 
ATOM   4380 C  CG2 . ILE A 1 588 ? -9.522  -67.250 -18.257 0.40 26.86  ? 851  ILE A CG2 1 
ATOM   4381 C  CD1 . ILE A 1 588 ? -7.255  -66.738 -20.183 0.40 27.93  ? 851  ILE A CD1 1 
ATOM   4382 N  N   . GLY A 1 589 ? -6.487  -69.567 -15.637 1.00 35.21  ? 852  GLY A N   1 
ATOM   4383 C  CA  . GLY A 1 589 ? -5.257  -70.251 -15.185 1.00 37.49  ? 852  GLY A CA  1 
ATOM   4384 C  C   . GLY A 1 589 ? -5.241  -70.422 -13.680 1.00 40.02  ? 852  GLY A C   1 
ATOM   4385 O  O   . GLY A 1 589 ? -4.605  -71.354 -13.206 1.00 41.38  ? 852  GLY A O   1 
ATOM   4386 N  N   . LEU A 1 590 ? -5.939  -69.541 -12.968 1.00 39.02  ? 853  LEU A N   1 
ATOM   4387 C  CA  . LEU A 1 590 ? -5.968  -69.579 -11.492 1.00 35.51  ? 853  LEU A CA  1 
ATOM   4388 C  C   . LEU A 1 590 ? -6.998  -70.588 -10.978 1.00 41.24  ? 853  LEU A C   1 
ATOM   4389 O  O   . LEU A 1 590 ? -8.042  -70.750 -11.616 1.00 38.60  ? 853  LEU A O   1 
ATOM   4390 C  CB  . LEU A 1 590 ? -6.261  -68.173 -10.974 1.00 38.34  ? 853  LEU A CB  1 
ATOM   4391 C  CG  . LEU A 1 590 ? -5.234  -67.099 -11.329 1.00 42.23  ? 853  LEU A CG  1 
ATOM   4392 C  CD1 . LEU A 1 590 ? -5.515  -65.817 -10.565 1.00 46.26  ? 853  LEU A CD1 1 
ATOM   4393 C  CD2 . LEU A 1 590 ? -3.818  -67.578 -11.053 1.00 41.45  ? 853  LEU A CD2 1 
ATOM   4394 N  N   . THR A 1 591 ? -6.681  -71.238 -9.860  1.00 42.05  ? 854  THR A N   1 
ATOM   4395 C  CA  . THR A 1 591 ? -7.583  -72.234 -9.225  1.00 43.21  ? 854  THR A CA  1 
ATOM   4396 C  C   . THR A 1 591 ? -8.843  -71.521 -8.734  1.00 35.82  ? 854  THR A C   1 
ATOM   4397 O  O   . THR A 1 591 ? -9.918  -72.100 -8.861  1.00 39.27  ? 854  THR A O   1 
ATOM   4398 C  CB  . THR A 1 591 ? -6.824  -72.952 -8.103  1.00 39.17  ? 854  THR A CB  1 
ATOM   4399 O  OG1 . THR A 1 591 ? -5.793  -73.725 -8.713  1.00 47.14  ? 854  THR A OG1 1 
ATOM   4400 C  CG2 . THR A 1 591 ? -7.704  -73.844 -7.259  1.00 43.60  ? 854  THR A CG2 1 
ATOM   4401 N  N   . SER A 1 592 ? -8.687  -70.316 -8.195  1.00 35.84  ? 855  SER A N   1 
ATOM   4402 C  CA  . SER A 1 592 ? -9.841  -69.513 -7.713  1.00 38.80  ? 855  SER A CA  1 
ATOM   4403 C  C   . SER A 1 592 ? -10.853 -69.275 -8.846  1.00 36.17  ? 855  SER A C   1 
ATOM   4404 O  O   . SER A 1 592 ? -12.047 -69.460 -8.602  1.00 40.85  ? 855  SER A O   1 
ATOM   4405 C  CB  . SER A 1 592 ? -9.358  -68.217 -7.119  1.00 35.19  ? 855  SER A CB  1 
ATOM   4406 O  OG  . SER A 1 592 ? -8.651  -67.443 -8.072  1.00 40.19  ? 855  SER A OG  1 
ATOM   4407 N  N   . ARG A 1 593 ? -10.383 -68.890 -10.032 0.40 35.47  ? 856  ARG A N   1 
ATOM   4408 C  CA  . ARG A 1 593 ? -11.291 -68.579 -11.169 0.40 35.83  ? 856  ARG A CA  1 
ATOM   4409 C  C   . ARG A 1 593 ? -12.000 -69.859 -11.624 0.40 36.88  ? 856  ARG A C   1 
ATOM   4410 O  O   . ARG A 1 593 ? -13.189 -69.779 -11.959 0.40 33.40  ? 856  ARG A O   1 
ATOM   4411 C  CB  . ARG A 1 593 ? -10.476 -67.933 -12.294 0.40 35.51  ? 856  ARG A CB  1 
ATOM   4412 C  CG  . ARG A 1 593 ? -11.298 -67.266 -13.387 0.40 35.70  ? 856  ARG A CG  1 
ATOM   4413 C  CD  . ARG A 1 593 ? -11.791 -68.226 -14.451 0.40 35.45  ? 856  ARG A CD  1 
ATOM   4414 N  NE  . ARG A 1 593 ? -12.319 -67.501 -15.595 0.40 36.79  ? 856  ARG A NE  1 
ATOM   4415 C  CZ  . ARG A 1 593 ? -12.942 -68.063 -16.622 0.40 35.47  ? 856  ARG A CZ  1 
ATOM   4416 N  NH1 . ARG A 1 593 ? -13.129 -69.371 -16.648 0.40 35.55  ? 856  ARG A NH1 1 
ATOM   4417 N  NH2 . ARG A 1 593 ? -13.384 -67.314 -17.615 0.40 33.96  ? 856  ARG A NH2 1 
ATOM   4418 N  N   . ALA A 1 594 ? -11.292 -70.988 -11.624 1.00 34.45  ? 857  ALA A N   1 
ATOM   4419 C  CA  . ALA A 1 594 ? -11.857 -72.273 -12.090 1.00 37.04  ? 857  ALA A CA  1 
ATOM   4420 C  C   . ALA A 1 594 ? -12.964 -72.761 -11.151 1.00 37.75  ? 857  ALA A C   1 
ATOM   4421 O  O   . ALA A 1 594 ? -13.977 -73.242 -11.651 1.00 32.80  ? 857  ALA A O   1 
ATOM   4422 C  CB  . ALA A 1 594 ? -10.747 -73.275 -12.198 1.00 42.36  ? 857  ALA A CB  1 
ATOM   4423 N  N   . THR A 1 595 ? -12.755 -72.644 -9.843  1.00 35.25  ? 858  THR A N   1 
ATOM   4424 C  CA  . THR A 1 595 ? -13.803 -73.018 -8.865  1.00 38.63  ? 858  THR A CA  1 
ATOM   4425 C  C   . THR A 1 595 ? -15.000 -72.095 -9.081  1.00 40.88  ? 858  THR A C   1 
ATOM   4426 O  O   . THR A 1 595 ? -16.129 -72.587 -9.039  1.00 38.81  ? 858  THR A O   1 
ATOM   4427 C  CB  . THR A 1 595 ? -13.279 -72.916 -7.430  1.00 39.82  ? 858  THR A CB  1 
ATOM   4428 O  OG1 . THR A 1 595 ? -12.051 -73.638 -7.346  1.00 52.67  ? 858  THR A OG1 1 
ATOM   4429 C  CG2 . THR A 1 595 ? -14.262 -73.449 -6.413  1.00 42.84  ? 858  THR A CG2 1 
ATOM   4430 N  N   . TRP A 1 596 ? -14.736 -70.813 -9.318  1.00 38.10  ? 859  TRP A N   1 
ATOM   4431 C  CA  . TRP A 1 596 ? -15.808 -69.816 -9.562  1.00 34.34  ? 859  TRP A CA  1 
ATOM   4432 C  C   . TRP A 1 596 ? -16.622 -70.215 -10.793 1.00 32.51  ? 859  TRP A C   1 
ATOM   4433 O  O   . TRP A 1 596 ? -17.842 -70.271 -10.678 1.00 34.59  ? 859  TRP A O   1 
ATOM   4434 C  CB  . TRP A 1 596 ? -15.171 -68.428 -9.697  1.00 31.98  ? 859  TRP A CB  1 
ATOM   4435 C  CG  . TRP A 1 596 ? -16.053 -67.322 -10.181 1.00 28.31  ? 859  TRP A CG  1 
ATOM   4436 C  CD1 . TRP A 1 596 ? -17.105 -66.754 -9.527  1.00 29.01  ? 859  TRP A CD1 1 
ATOM   4437 C  CD2 . TRP A 1 596 ? -15.905 -66.594 -11.410 1.00 31.42  ? 859  TRP A CD2 1 
ATOM   4438 N  NE1 . TRP A 1 596 ? -17.639 -65.743 -10.276 1.00 30.85  ? 859  TRP A NE1 1 
ATOM   4439 C  CE2 . TRP A 1 596 ? -16.924 -65.620 -11.436 1.00 31.29  ? 859  TRP A CE2 1 
ATOM   4440 C  CE3 . TRP A 1 596 ? -15.023 -66.678 -12.491 1.00 31.55  ? 859  TRP A CE3 1 
ATOM   4441 C  CZ2 . TRP A 1 596 ? -17.083 -64.741 -12.504 1.00 30.22  ? 859  TRP A CZ2 1 
ATOM   4442 C  CZ3 . TRP A 1 596 ? -15.180 -65.808 -13.546 1.00 34.62  ? 859  TRP A CZ3 1 
ATOM   4443 C  CH2 . TRP A 1 596 ? -16.197 -64.855 -13.549 1.00 36.25  ? 859  TRP A CH2 1 
ATOM   4444 N  N   . ALA A 1 597 ? -15.953 -70.507 -11.907 0.40 32.49  ? 860  ALA A N   1 
ATOM   4445 C  CA  . ALA A 1 597 ? -16.663 -70.841 -13.162 0.40 33.74  ? 860  ALA A CA  1 
ATOM   4446 C  C   . ALA A 1 597 ? -17.464 -72.138 -13.001 0.40 33.86  ? 860  ALA A C   1 
ATOM   4447 O  O   . ALA A 1 597 ? -18.638 -72.152 -13.394 0.40 31.11  ? 860  ALA A O   1 
ATOM   4448 C  CB  . ALA A 1 597 ? -15.664 -70.951 -14.283 0.40 33.39  ? 860  ALA A CB  1 
ATOM   4449 N  N   . LYS A 1 598 ? -16.852 -73.178 -12.434 0.40 34.20  ? 861  LYS A N   1 
ATOM   4450 C  CA  . LYS A 1 598 ? -17.522 -74.499 -12.314 0.40 34.04  ? 861  LYS A CA  1 
ATOM   4451 C  C   . LYS A 1 598 ? -18.733 -74.413 -11.383 0.40 33.87  ? 861  LYS A C   1 
ATOM   4452 O  O   . LYS A 1 598 ? -19.725 -75.095 -11.670 0.40 32.97  ? 861  LYS A O   1 
ATOM   4453 C  CB  . LYS A 1 598 ? -16.529 -75.540 -11.793 0.40 37.69  ? 861  LYS A CB  1 
ATOM   4454 C  CG  . LYS A 1 598 ? -17.001 -76.985 -11.872 0.40 39.28  ? 861  LYS A CG  1 
ATOM   4455 C  CD  . LYS A 1 598 ? -15.973 -77.981 -11.378 0.40 40.71  ? 861  LYS A CD  1 
ATOM   4456 C  CE  . LYS A 1 598 ? -16.321 -79.412 -11.729 0.40 41.56  ? 861  LYS A CE  1 
ATOM   4457 N  NZ  . LYS A 1 598 ? -17.673 -79.783 -11.247 0.40 40.72  ? 861  LYS A NZ  1 
ATOM   4458 N  N   . ASN A 1 599 ? -18.650 -73.613 -10.319 0.40 33.47  ? 862  ASN A N   1 
ATOM   4459 C  CA  . ASN A 1 599 ? -19.745 -73.546 -9.314  0.40 33.86  ? 862  ASN A CA  1 
ATOM   4460 C  C   . ASN A 1 599 ? -20.539 -72.244 -9.466  0.40 32.73  ? 862  ASN A C   1 
ATOM   4461 O  O   . ASN A 1 599 ? -21.082 -71.775 -8.456  0.40 33.34  ? 862  ASN A O   1 
ATOM   4462 C  CB  . ASN A 1 599 ? -19.182 -73.690 -7.899  0.40 33.39  ? 862  ASN A CB  1 
ATOM   4463 C  CG  . ASN A 1 599 ? -18.344 -74.937 -7.721  0.40 33.43  ? 862  ASN A CG  1 
ATOM   4464 O  OD1 . ASN A 1 599 ? -18.590 -75.953 -8.365  0.40 33.09  ? 862  ASN A OD1 1 
ATOM   4465 N  ND2 . ASN A 1 599 ? -17.356 -74.873 -6.846  0.40 33.66  ? 862  ASN A ND2 1 
ATOM   4466 N  N   . ILE A 1 600 ? -20.622 -71.698 -10.681 0.40 33.99  ? 863  ILE A N   1 
ATOM   4467 C  CA  . ILE A 1 600 ? -21.298 -70.382 -10.902 0.40 34.26  ? 863  ILE A CA  1 
ATOM   4468 C  C   . ILE A 1 600 ? -22.785 -70.467 -10.528 0.40 35.88  ? 863  ILE A C   1 
ATOM   4469 O  O   . ILE A 1 600 ? -23.272 -69.526 -9.884  0.40 34.50  ? 863  ILE A O   1 
ATOM   4470 C  CB  . ILE A 1 600 ? -21.093 -69.903 -12.355 0.40 33.73  ? 863  ILE A CB  1 
ATOM   4471 C  CG1 . ILE A 1 600 ? -21.412 -68.414 -12.508 0.40 35.88  ? 863  ILE A CG1 1 
ATOM   4472 C  CG2 . ILE A 1 600 ? -21.880 -70.760 -13.335 0.40 34.78  ? 863  ILE A CG2 1 
ATOM   4473 C  CD1 . ILE A 1 600 ? -20.540 -67.513 -11.667 0.40 34.88  ? 863  ILE A CD1 1 
ATOM   4474 N  N   A GLN A 1 601 ? -23.415 -71.669 -10.873 0.20 35.34  ? 864  GLN A N   1 
ATOM   4475 N  N   B GLN A 1 601 ? -23.456 -71.575 -10.857 0.20 36.00  ? 864  GLN A N   1 
ATOM   4476 C  CA  A GLN A 1 601 ? -24.880 -71.830 -10.637 0.20 35.86  ? 864  GLN A CA  1 
ATOM   4477 C  CA  B GLN A 1 601 ? -24.919 -71.680 -10.603 0.20 36.81  ? 864  GLN A CA  1 
ATOM   4478 C  C   A GLN A 1 601 ? -25.204 -71.632 -9.150  0.20 33.46  ? 864  GLN A C   1 
ATOM   4479 C  C   B GLN A 1 601 ? -25.183 -71.500 -9.104  0.20 34.00  ? 864  GLN A C   1 
ATOM   4480 O  O   A GLN A 1 601 ? -26.284 -71.104 -8.850  0.20 33.63  ? 864  GLN A O   1 
ATOM   4481 O  O   B GLN A 1 601 ? -26.307 -71.096 -8.761  0.20 34.12  ? 864  GLN A O   1 
ATOM   4482 C  CB  A GLN A 1 601 ? -25.386 -73.195 -11.119 0.20 36.45  ? 864  GLN A CB  1 
ATOM   4483 C  CB  B GLN A 1 601 ? -25.465 -73.010 -11.124 0.20 38.08  ? 864  GLN A CB  1 
ATOM   4484 C  CG  A GLN A 1 601 ? -25.177 -73.454 -12.608 0.20 35.14  ? 864  GLN A CG  1 
ATOM   4485 C  CG  B GLN A 1 601 ? -26.978 -73.122 -11.013 0.20 36.89  ? 864  GLN A CG  1 
ATOM   4486 C  CD  A GLN A 1 601 ? -25.884 -72.473 -13.511 0.20 34.21  ? 864  GLN A CD  1 
ATOM   4487 C  CD  B GLN A 1 601 ? -27.682 -71.984 -11.713 0.20 38.20  ? 864  GLN A CD  1 
ATOM   4488 O  OE1 A GLN A 1 601 ? -26.787 -71.751 -13.095 0.20 34.37  ? 864  GLN A OE1 1 
ATOM   4489 O  OE1 B GLN A 1 601 ? -27.286 -71.553 -12.793 0.20 38.54  ? 864  GLN A OE1 1 
ATOM   4490 N  NE2 A GLN A 1 601 ? -25.483 -72.456 -14.773 0.20 33.67  ? 864  GLN A NE2 1 
ATOM   4491 N  NE2 B GLN A 1 601 ? -28.745 -71.492 -11.098 0.20 38.81  ? 864  GLN A NE2 1 
ATOM   4492 N  N   . THR A 1 602 ? -24.297 -72.034 -8.262  1.00 32.24  ? 865  THR A N   1 
ATOM   4493 C  CA  . THR A 1 602 ? -24.429 -71.846 -6.793  1.00 32.64  ? 865  THR A CA  1 
ATOM   4494 C  C   . THR A 1 602 ? -24.354 -70.360 -6.404  1.00 34.42  ? 865  THR A C   1 
ATOM   4495 O  O   . THR A 1 602 ? -24.992 -69.951 -5.410  1.00 36.07  ? 865  THR A O   1 
ATOM   4496 C  CB  . THR A 1 602 ? -23.323 -72.617 -6.080  1.00 36.53  ? 865  THR A CB  1 
ATOM   4497 O  OG1 . THR A 1 602 ? -23.440 -73.971 -6.530  1.00 43.21  ? 865  THR A OG1 1 
ATOM   4498 C  CG2 . THR A 1 602 ? -23.408 -72.488 -4.580  1.00 40.06  ? 865  THR A CG2 1 
ATOM   4499 N  N   . ALA A 1 603 ? -23.539 -69.549 -7.075  1.00 36.63  ? 866  ALA A N   1 
ATOM   4500 C  CA  . ALA A 1 603 ? -23.450 -68.114 -6.742  1.00 35.09  ? 866  ALA A CA  1 
ATOM   4501 C  C   . ALA A 1 603 ? -24.729 -67.475 -7.235  1.00 30.89  ? 866  ALA A C   1 
ATOM   4502 O  O   . ALA A 1 603 ? -25.257 -66.632 -6.560  1.00 28.48  ? 866  ALA A O   1 
ATOM   4503 C  CB  . ALA A 1 603 ? -22.264 -67.443 -7.389  1.00 35.43  ? 866  ALA A CB  1 
ATOM   4504 N  N   . ILE A 1 604 ? -25.120 -67.805 -8.457  1.00 30.39  ? 867  ILE A N   1 
ATOM   4505 C  CA  . ILE A 1 604 ? -26.366 -67.272 -9.065  1.00 33.12  ? 867  ILE A CA  1 
ATOM   4506 C  C   . ILE A 1 604 ? -27.538 -67.561 -8.104  1.00 32.08  ? 867  ILE A C   1 
ATOM   4507 O  O   . ILE A 1 604 ? -28.260 -66.639 -7.741  1.00 34.79  ? 867  ILE A O   1 
ATOM   4508 C  CB  . ILE A 1 604 ? -26.522 -67.891 -10.454 1.00 33.23  ? 867  ILE A CB  1 
ATOM   4509 C  CG1 . ILE A 1 604 ? -25.482 -67.305 -11.418 1.00 31.87  ? 867  ILE A CG1 1 
ATOM   4510 C  CG2 . ILE A 1 604 ? -27.944 -67.724 -10.952 1.00 36.54  ? 867  ILE A CG2 1 
ATOM   4511 C  CD1 . ILE A 1 604 ? -25.446 -67.964 -12.812 1.00 34.77  ? 867  ILE A CD1 1 
ATOM   4512 N  N   . ASN A 1 605 ? -27.605 -68.774 -7.560  1.00 37.41  ? 868  ASN A N   1 
ATOM   4513 C  CA  . ASN A 1 605 ? -28.705 -69.198 -6.654  1.00 41.16  ? 868  ASN A CA  1 
ATOM   4514 C  C   . ASN A 1 605 ? -28.626 -68.418 -5.338  1.00 38.68  ? 868  ASN A C   1 
ATOM   4515 O  O   . ASN A 1 605 ? -29.671 -68.128 -4.808  1.00 38.03  ? 868  ASN A O   1 
ATOM   4516 C  CB  . ASN A 1 605 ? -28.750 -70.721 -6.478  1.00 42.72  ? 868  ASN A CB  1 
ATOM   4517 C  CG  . ASN A 1 605 ? -29.274 -71.433 -7.717  1.00 49.03  ? 868  ASN A CG  1 
ATOM   4518 O  OD1 . ASN A 1 605 ? -30.019 -70.885 -8.532  1.00 56.72  ? 868  ASN A OD1 1 
ATOM   4519 N  ND2 . ASN A 1 605 ? -28.830 -72.652 -7.923  1.00 53.91  ? 868  ASN A ND2 1 
ATOM   4520 N  N   . GLN A 1 606 ? -27.441 -68.109 -4.810  1.00 41.22  ? 869  GLN A N   1 
ATOM   4521 C  CA  . GLN A 1 606 ? -27.316 -67.333 -3.549  1.00 35.25  ? 869  GLN A CA  1 
ATOM   4522 C  C   . GLN A 1 606 ? -28.005 -65.971 -3.754  1.00 34.77  ? 869  GLN A C   1 
ATOM   4523 O  O   . GLN A 1 606 ? -28.715 -65.495 -2.834  1.00 34.83  ? 869  GLN A O   1 
ATOM   4524 C  CB  . GLN A 1 606 ? -25.860 -67.134 -3.126  1.00 38.02  ? 869  GLN A CB  1 
ATOM   4525 C  CG  . GLN A 1 606 ? -25.717 -66.300 -1.838  1.00 44.41  ? 869  GLN A CG  1 
ATOM   4526 C  CD  . GLN A 1 606 ? -24.284 -65.979 -1.461  1.00 54.15  ? 869  GLN A CD  1 
ATOM   4527 O  OE1 . GLN A 1 606 ? -23.396 -65.960 -2.326  1.00 54.28  ? 869  GLN A OE1 1 
ATOM   4528 N  NE2 . GLN A 1 606 ? -24.044 -65.756 -0.172  1.00 43.51  ? 869  GLN A NE2 1 
ATOM   4529 N  N   . VAL A 1 607 ? -27.732 -65.310 -4.875  1.00 27.87  ? 870  VAL A N   1 
ATOM   4530 C  CA  . VAL A 1 607 ? -28.259 -63.950 -5.139  1.00 30.94  ? 870  VAL A CA  1 
ATOM   4531 C  C   . VAL A 1 607 ? -29.780 -64.090 -5.412  1.00 29.67  ? 870  VAL A C   1 
ATOM   4532 O  O   . VAL A 1 607 ? -30.558 -63.268 -4.881  1.00 30.93  ? 870  VAL A O   1 
ATOM   4533 C  CB  . VAL A 1 607 ? -27.497 -63.297 -6.303  1.00 31.52  ? 870  VAL A CB  1 
ATOM   4534 C  CG1 . VAL A 1 607 ? -28.195 -62.052 -6.829  1.00 29.43  ? 870  VAL A CG1 1 
ATOM   4535 C  CG2 . VAL A 1 607 ? -26.052 -63.029 -5.912  1.00 33.54  ? 870  VAL A CG2 1 
ATOM   4536 N  N   . ARG A 1 608 ? -30.193 -65.083 -6.203  1.00 30.75  ? 871  ARG A N   1 
ATOM   4537 C  CA  . ARG A 1 608 ? -31.644 -65.363 -6.415  1.00 33.54  ? 871  ARG A CA  1 
ATOM   4538 C  C   . ARG A 1 608 ? -32.368 -65.539 -5.069  1.00 37.34  ? 871  ARG A C   1 
ATOM   4539 O  O   . ARG A 1 608 ? -33.475 -64.970 -4.910  1.00 39.09  ? 871  ARG A O   1 
ATOM   4540 C  CB  . ARG A 1 608 ? -31.851 -66.588 -7.298  1.00 31.66  ? 871  ARG A CB  1 
ATOM   4541 C  CG  . ARG A 1 608 ? -31.541 -66.303 -8.754  1.00 31.89  ? 871  ARG A CG  1 
ATOM   4542 C  CD  . ARG A 1 608 ? -31.683 -67.551 -9.566  1.00 33.42  ? 871  ARG A CD  1 
ATOM   4543 N  NE  . ARG A 1 608 ? -31.644 -67.264 -10.992 1.00 38.56  ? 871  ARG A NE  1 
ATOM   4544 C  CZ  . ARG A 1 608 ? -31.567 -68.210 -11.925 1.00 41.51  ? 871  ARG A CZ  1 
ATOM   4545 N  NH1 . ARG A 1 608 ? -31.568 -69.480 -11.558 1.00 47.40  ? 871  ARG A NH1 1 
ATOM   4546 N  NH2 . ARG A 1 608 ? -31.449 -67.906 -13.209 1.00 40.66  ? 871  ARG A NH2 1 
ATOM   4547 N  N   . SER A 1 609 ? -31.808 -66.293 -4.124  1.00 30.93  ? 872  SER A N   1 
ATOM   4548 C  CA  . SER A 1 609 ? -32.450 -66.466 -2.799  1.00 35.20  ? 872  SER A CA  1 
ATOM   4549 C  C   . SER A 1 609 ? -32.555 -65.139 -2.055  1.00 37.86  ? 872  SER A C   1 
ATOM   4550 O  O   . SER A 1 609 ? -33.454 -65.028 -1.230  1.00 35.93  ? 872  SER A O   1 
ATOM   4551 C  CB  . SER A 1 609 ? -31.743 -67.493 -1.974  1.00 36.67  ? 872  SER A CB  1 
ATOM   4552 O  OG  . SER A 1 609 ? -31.583 -68.664 -2.768  1.00 37.38  ? 872  SER A OG  1 
ATOM   4553 N  N   . LEU A 1 610 ? -31.632 -64.199 -2.245  1.00 38.06  ? 873  LEU A N   1 
ATOM   4554 C  CA  . LEU A 1 610 ? -31.655 -62.942 -1.458  1.00 36.55  ? 873  LEU A CA  1 
ATOM   4555 C  C   . LEU A 1 610 ? -32.752 -62.027 -2.009  1.00 34.92  ? 873  LEU A C   1 
ATOM   4556 O  O   . LEU A 1 610 ? -33.457 -61.384 -1.216  1.00 35.71  ? 873  LEU A O   1 
ATOM   4557 C  CB  . LEU A 1 610 ? -30.278 -62.287 -1.536  1.00 39.04  ? 873  LEU A CB  1 
ATOM   4558 C  CG  . LEU A 1 610 ? -29.177 -62.965 -0.727  1.00 37.09  ? 873  LEU A CG  1 
ATOM   4559 C  CD1 . LEU A 1 610 ? -27.823 -62.361 -1.089  1.00 39.25  ? 873  LEU A CD1 1 
ATOM   4560 C  CD2 . LEU A 1 610 ? -29.423 -62.878 0.786   1.00 34.77  ? 873  LEU A CD2 1 
ATOM   4561 N  N   . ILE A 1 611 ? -32.853 -61.947 -3.329  1.00 33.18  ? 874  ILE A N   1 
ATOM   4562 C  CA  . ILE A 1 611 ? -33.836 -61.090 -4.041  1.00 37.39  ? 874  ILE A CA  1 
ATOM   4563 C  C   . ILE A 1 611 ? -35.252 -61.694 -3.858  1.00 41.25  ? 874  ILE A C   1 
ATOM   4564 O  O   . ILE A 1 611 ? -36.200 -60.925 -3.555  1.00 43.47  ? 874  ILE A O   1 
ATOM   4565 C  CB  . ILE A 1 611 ? -33.415 -60.912 -5.517  1.00 37.17  ? 874  ILE A CB  1 
ATOM   4566 C  CG1 . ILE A 1 611 ? -32.104 -60.119 -5.636  1.00 37.69  ? 874  ILE A CG1 1 
ATOM   4567 C  CG2 . ILE A 1 611 ? -34.550 -60.251 -6.283  1.00 40.49  ? 874  ILE A CG2 1 
ATOM   4568 C  CD1 . ILE A 1 611 ? -31.512 -60.014 -7.029  1.00 35.53  ? 874  ILE A CD1 1 
ATOM   4569 N  N   . GLY A 1 612 ? -35.377 -63.022 -3.943  1.00 37.66  ? 875  GLY A N   1 
ATOM   4570 C  CA  . GLY A 1 612 ? -36.615 -63.776 -3.639  1.00 42.42  ? 875  GLY A CA  1 
ATOM   4571 C  C   . GLY A 1 612 ? -37.231 -64.434 -4.869  1.00 42.36  ? 875  GLY A C   1 
ATOM   4572 O  O   . GLY A 1 612 ? -36.552 -64.685 -5.872  1.00 38.47  ? 875  GLY A O   1 
ATOM   4573 N  N   . ASN A 1 613 ? -38.535 -64.675 -4.816  1.00 53.78  ? 876  ASN A N   1 
ATOM   4574 C  CA  . ASN A 1 613 ? -39.262 -65.554 -5.767  1.00 51.61  ? 876  ASN A CA  1 
ATOM   4575 C  C   . ASN A 1 613 ? -39.806 -64.685 -6.909  1.00 47.12  ? 876  ASN A C   1 
ATOM   4576 O  O   . ASN A 1 613 ? -40.933 -64.188 -6.804  1.00 63.10  ? 876  ASN A O   1 
ATOM   4577 C  CB  . ASN A 1 613 ? -40.341 -66.345 -5.017  1.00 59.37  ? 876  ASN A CB  1 
ATOM   4578 C  CG  . ASN A 1 613 ? -41.006 -67.388 -5.887  1.00 66.32  ? 876  ASN A CG  1 
ATOM   4579 O  OD1 . ASN A 1 613 ? -40.443 -67.806 -6.897  1.00 69.92  ? 876  ASN A OD1 1 
ATOM   4580 N  ND2 . ASN A 1 613 ? -42.196 -67.831 -5.496  1.00 69.87  ? 876  ASN A ND2 1 
ATOM   4581 N  N   . GLU A 1 614 ? -39.025 -64.573 -7.970  1.00 39.41  ? 877  GLU A N   1 
ATOM   4582 C  CA  . GLU A 1 614 ? -39.178 -63.638 -9.107  1.00 36.33  ? 877  GLU A CA  1 
ATOM   4583 C  C   . GLU A 1 614 ? -38.986 -64.513 -10.335 1.00 33.83  ? 877  GLU A C   1 
ATOM   4584 O  O   . GLU A 1 614 ? -38.715 -65.725 -10.131 1.00 33.82  ? 877  GLU A O   1 
ATOM   4585 C  CB  . GLU A 1 614 ? -38.142 -62.523 -9.044  1.00 38.42  ? 877  GLU A CB  1 
ATOM   4586 C  CG  . GLU A 1 614 ? -38.263 -61.627 -7.839  1.00 38.80  ? 877  GLU A CG  1 
ATOM   4587 C  CD  . GLU A 1 614 ? -39.436 -60.637 -7.899  1.00 42.13  ? 877  GLU A CD  1 
ATOM   4588 O  OE1 . GLU A 1 614 ? -40.017 -60.416 -9.006  1.00 35.91  ? 877  GLU A OE1 1 
ATOM   4589 O  OE2 . GLU A 1 614 ? -39.728 -60.027 -6.828  1.00 36.89  ? 877  GLU A OE2 1 
ATOM   4590 N  N   . GLU A 1 615 ? -39.188 -63.976 -11.533 1.00 40.15  ? 878  GLU A N   1 
ATOM   4591 C  CA  . GLU A 1 615 ? -38.955 -64.734 -12.797 1.00 48.09  ? 878  GLU A CA  1 
ATOM   4592 C  C   . GLU A 1 615 ? -37.510 -64.446 -13.244 1.00 49.35  ? 878  GLU A C   1 
ATOM   4593 O  O   . GLU A 1 615 ? -37.231 -63.273 -13.554 1.00 46.51  ? 878  GLU A O   1 
ATOM   4594 C  CB  . GLU A 1 615 ? -39.961 -64.339 -13.886 1.00 56.44  ? 878  GLU A CB  1 
ATOM   4595 C  CG  . GLU A 1 615 ? -39.725 -65.056 -15.215 1.00 68.95  ? 878  GLU A CG  1 
ATOM   4596 C  CD  . GLU A 1 615 ? -40.568 -64.545 -16.383 1.00 90.22  ? 878  GLU A CD  1 
ATOM   4597 O  OE1 . GLU A 1 615 ? -41.482 -63.713 -16.143 1.00 93.93  ? 878  GLU A OE1 1 
ATOM   4598 O  OE2 . GLU A 1 615 ? -40.315 -64.971 -17.541 1.00 98.05  ? 878  GLU A OE2 1 
ATOM   4599 N  N   . TYR A 1 616 ? -36.673 -65.488 -13.288 1.00 46.28  ? 879  TYR A N   1 
ATOM   4600 C  CA  . TYR A 1 616 ? -35.258 -65.498 -13.729 1.00 51.49  ? 879  TYR A CA  1 
ATOM   4601 C  C   . TYR A 1 616 ? -35.129 -66.307 -15.023 1.00 54.71  ? 879  TYR A C   1 
ATOM   4602 O  O   . TYR A 1 616 ? -35.938 -67.218 -15.260 1.00 47.09  ? 879  TYR A O   1 
ATOM   4603 C  CB  . TYR A 1 616 ? -34.368 -66.089 -12.629 1.00 44.36  ? 879  TYR A CB  1 
ATOM   4604 C  CG  . TYR A 1 616 ? -34.485 -65.395 -11.291 1.00 43.22  ? 879  TYR A CG  1 
ATOM   4605 C  CD1 . TYR A 1 616 ? -33.733 -64.265 -11.017 1.00 37.93  ? 879  TYR A CD1 1 
ATOM   4606 C  CD2 . TYR A 1 616 ? -35.310 -65.893 -10.284 1.00 40.00  ? 879  TYR A CD2 1 
ATOM   4607 C  CE1 . TYR A 1 616 ? -33.788 -63.653 -9.773  1.00 40.46  ? 879  TYR A CE1 1 
ATOM   4608 C  CE2 . TYR A 1 616 ? -35.369 -65.299 -9.036  1.00 36.28  ? 879  TYR A CE2 1 
ATOM   4609 C  CZ  . TYR A 1 616 ? -34.615 -64.166 -8.782  1.00 40.61  ? 879  TYR A CZ  1 
ATOM   4610 O  OH  . TYR A 1 616 ? -34.667 -63.518 -7.577  1.00 40.60  ? 879  TYR A OH  1 
ATOM   4611 N  N   . THR A 1 617 ? -34.120 -65.959 -15.827 1.00 54.75  ? 880  THR A N   1 
ATOM   4612 C  CA  . THR A 1 617 ? -33.625 -66.713 -17.009 1.00 51.46  ? 880  THR A CA  1 
ATOM   4613 C  C   . THR A 1 617 ? -32.203 -67.223 -16.715 1.00 50.13  ? 880  THR A C   1 
ATOM   4614 O  O   . THR A 1 617 ? -31.438 -66.481 -16.069 1.00 41.93  ? 880  THR A O   1 
ATOM   4615 C  CB  . THR A 1 617 ? -33.603 -65.774 -18.214 1.00 58.31  ? 880  THR A CB  1 
ATOM   4616 O  OG1 . THR A 1 617 ? -34.840 -65.070 -18.140 1.00 51.13  ? 880  THR A OG1 1 
ATOM   4617 C  CG2 . THR A 1 617 ? -33.390 -66.469 -19.543 1.00 55.66  ? 880  THR A CG2 1 
ATOM   4618 N  N   . ASP A 1 618 ? -31.872 -68.438 -17.152 1.00 44.75  ? 881  ASP A N   1 
ATOM   4619 C  CA  . ASP A 1 618 ? -30.497 -68.993 -17.086 1.00 47.48  ? 881  ASP A CA  1 
ATOM   4620 C  C   . ASP A 1 618 ? -29.801 -68.627 -18.406 1.00 44.24  ? 881  ASP A C   1 
ATOM   4621 O  O   . ASP A 1 618 ? -30.115 -69.231 -19.441 1.00 38.52  ? 881  ASP A O   1 
ATOM   4622 C  CB  . ASP A 1 618 ? -30.537 -70.508 -16.836 1.00 50.10  ? 881  ASP A CB  1 
ATOM   4623 C  CG  . ASP A 1 618 ? -29.183 -71.227 -16.756 1.00 63.31  ? 881  ASP A CG  1 
ATOM   4624 O  OD1 . ASP A 1 618 ? -28.131 -70.570 -16.381 1.00 52.48  ? 881  ASP A OD1 1 
ATOM   4625 O  OD2 . ASP A 1 618 ? -29.174 -72.464 -17.052 1.00 62.72  ? 881  ASP A OD2 1 
ATOM   4626 N  N   . TYR A 1 619 ? -28.864 -67.674 -18.361 0.40 43.65  ? 882  TYR A N   1 
ATOM   4627 C  CA  . TYR A 1 619 ? -28.082 -67.217 -19.540 0.40 43.51  ? 882  TYR A CA  1 
ATOM   4628 C  C   . TYR A 1 619 ? -26.775 -68.015 -19.669 0.40 43.50  ? 882  TYR A C   1 
ATOM   4629 O  O   . TYR A 1 619 ? -26.106 -67.883 -20.712 0.40 43.75  ? 882  TYR A O   1 
ATOM   4630 C  CB  . TYR A 1 619 ? -27.834 -65.711 -19.449 0.40 44.49  ? 882  TYR A CB  1 
ATOM   4631 C  CG  . TYR A 1 619 ? -29.088 -64.877 -19.522 0.40 46.15  ? 882  TYR A CG  1 
ATOM   4632 C  CD1 . TYR A 1 619 ? -29.736 -64.666 -20.730 0.40 47.21  ? 882  TYR A CD1 1 
ATOM   4633 C  CD2 . TYR A 1 619 ? -29.637 -64.304 -18.386 0.40 46.29  ? 882  TYR A CD2 1 
ATOM   4634 C  CE1 . TYR A 1 619 ? -30.891 -63.900 -20.809 0.40 46.89  ? 882  TYR A CE1 1 
ATOM   4635 C  CE2 . TYR A 1 619 ? -30.788 -63.533 -18.448 0.40 47.20  ? 882  TYR A CE2 1 
ATOM   4636 C  CZ  . TYR A 1 619 ? -31.417 -63.326 -19.663 0.40 47.16  ? 882  TYR A CZ  1 
ATOM   4637 O  OH  . TYR A 1 619 ? -32.555 -62.569 -19.721 0.40 46.54  ? 882  TYR A OH  1 
ATOM   4638 N  N   . MET A 1 620 ? -26.420 -68.826 -18.666 1.00 42.75  ? 883  MET A N   1 
ATOM   4639 C  CA  . MET A 1 620 ? -25.145 -69.620 -18.696 1.00 47.87  ? 883  MET A CA  1 
ATOM   4640 C  C   . MET A 1 620 ? -24.982 -70.566 -19.925 1.00 51.59  ? 883  MET A C   1 
ATOM   4641 O  O   . MET A 1 620 ? -23.885 -70.613 -20.500 1.00 57.06  ? 883  MET A O   1 
ATOM   4642 C  CB  . MET A 1 620 ? -24.867 -70.334 -17.364 1.00 43.44  ? 883  MET A CB  1 
ATOM   4643 C  CG  . MET A 1 620 ? -24.898 -69.440 -16.103 1.00 43.32  ? 883  MET A CG  1 
ATOM   4644 S  SD  . MET A 1 620 ? -24.114 -67.789 -16.302 1.00 45.16  ? 883  MET A SD  1 
ATOM   4645 C  CE  . MET A 1 620 ? -22.414 -68.300 -16.569 1.00 41.07  ? 883  MET A CE  1 
ATOM   4646 N  N   . PRO A 1 621 ? -26.030 -71.310 -20.358 0.40 60.12  ? 884  PRO A N   1 
ATOM   4647 C  CA  . PRO A 1 621 ? -25.944 -72.156 -21.555 0.40 63.91  ? 884  PRO A CA  1 
ATOM   4648 C  C   . PRO A 1 621 ? -25.683 -71.425 -22.885 0.40 70.19  ? 884  PRO A C   1 
ATOM   4649 O  O   . PRO A 1 621 ? -25.536 -72.107 -23.885 0.40 72.23  ? 884  PRO A O   1 
ATOM   4650 C  CB  . PRO A 1 621 ? -27.322 -72.841 -21.619 0.40 63.61  ? 884  PRO A CB  1 
ATOM   4651 C  CG  . PRO A 1 621 ? -27.853 -72.762 -20.203 0.40 61.58  ? 884  PRO A CG  1 
ATOM   4652 C  CD  . PRO A 1 621 ? -27.331 -71.440 -19.682 0.40 60.91  ? 884  PRO A CD  1 
ATOM   4653 N  N   . SER A 1 622 ? -25.637 -70.086 -22.883 0.40 78.39  ? 885  SER A N   1 
ATOM   4654 C  CA  . SER A 1 622 ? -25.192 -69.252 -24.035 0.40 86.47  ? 885  SER A CA  1 
ATOM   4655 C  C   . SER A 1 622 ? -23.712 -69.531 -24.340 0.40 94.42  ? 885  SER A C   1 
ATOM   4656 O  O   . SER A 1 622 ? -23.322 -69.430 -25.522 0.40 95.74  ? 885  SER A O   1 
ATOM   4657 C  CB  . SER A 1 622 ? -25.435 -67.779 -23.787 0.40 84.68  ? 885  SER A CB  1 
ATOM   4658 O  OG  . SER A 1 622 ? -24.555 -67.271 -22.794 0.40 82.30  ? 885  SER A OG  1 
ATOM   4659 N  N   . MET A 1 623 ? -22.927 -69.870 -23.311 0.40 100.87 ? 886  MET A N   1 
ATOM   4660 C  CA  . MET A 1 623 ? -21.499 -70.275 -23.435 0.40 110.62 ? 886  MET A CA  1 
ATOM   4661 C  C   . MET A 1 623 ? -21.440 -71.734 -23.907 0.40 118.11 ? 886  MET A C   1 
ATOM   4662 O  O   . MET A 1 623 ? -22.496 -72.394 -23.914 0.40 120.47 ? 886  MET A O   1 
ATOM   4663 C  CB  . MET A 1 623 ? -20.762 -70.132 -22.098 0.40 112.09 ? 886  MET A CB  1 
ATOM   4664 C  CG  . MET A 1 623 ? -21.002 -68.803 -21.400 0.40 111.98 ? 886  MET A CG  1 
ATOM   4665 S  SD  . MET A 1 623 ? -19.762 -68.451 -20.127 0.40 110.12 ? 886  MET A SD  1 
ATOM   4666 C  CE  . MET A 1 623 ? -18.596 -67.473 -21.073 0.40 110.46 ? 886  MET A CE  1 
ATOM   4667 N  N   . LYS A 1 624 ? -20.253 -72.214 -24.292 0.40 126.44 ? 887  LYS A N   1 
ATOM   4668 C  CA  . LYS A 1 624 ? -20.037 -73.595 -24.805 0.40 133.43 ? 887  LYS A CA  1 
ATOM   4669 C  C   . LYS A 1 624 ? -19.993 -74.585 -23.634 0.40 138.20 ? 887  LYS A C   1 
ATOM   4670 O  O   . LYS A 1 624 ? -20.668 -75.630 -23.724 0.40 139.40 ? 887  LYS A O   1 
ATOM   4671 C  CB  . LYS A 1 624 ? -18.750 -73.666 -25.633 0.40 137.26 ? 887  LYS A CB  1 
ATOM   4672 C  CG  . LYS A 1 624 ? -18.495 -75.007 -26.311 0.40 140.45 ? 887  LYS A CG  1 
ATOM   4673 C  CD  . LYS A 1 624 ? -17.300 -75.015 -27.246 0.40 144.00 ? 887  LYS A CD  1 
ATOM   4674 C  CE  . LYS A 1 624 ? -15.982 -75.289 -26.549 0.40 144.65 ? 887  LYS A CE  1 
ATOM   4675 N  NZ  . LYS A 1 624 ? -15.502 -74.126 -25.766 0.40 146.02 ? 887  LYS A NZ  1 
ATOM   4676 N  N   . ARG A 1 625 ? -19.229 -74.263 -22.584 0.40 140.51 ? 888  ARG A N   1 
ATOM   4677 C  CA  . ARG A 1 625 ? -18.901 -75.186 -21.461 0.40 141.07 ? 888  ARG A CA  1 
ATOM   4678 C  C   . ARG A 1 625 ? -20.170 -75.564 -20.681 0.40 138.79 ? 888  ARG A C   1 
ATOM   4679 O  O   . ARG A 1 625 ? -20.311 -76.755 -20.338 0.40 137.91 ? 888  ARG A O   1 
ATOM   4680 C  CB  . ARG A 1 625 ? -17.835 -74.570 -20.546 0.40 144.82 ? 888  ARG A CB  1 
ATOM   4681 C  CG  . ARG A 1 625 ? -18.255 -73.302 -19.814 0.40 148.32 ? 888  ARG A CG  1 
ATOM   4682 C  CD  . ARG A 1 625 ? -17.198 -72.868 -18.817 0.40 149.18 ? 888  ARG A CD  1 
ATOM   4683 N  NE  . ARG A 1 625 ? -17.150 -73.752 -17.657 0.40 149.77 ? 888  ARG A NE  1 
ATOM   4684 C  CZ  . ARG A 1 625 ? -16.152 -73.811 -16.776 0.40 151.19 ? 888  ARG A CZ  1 
ATOM   4685 N  NH1 . ARG A 1 625 ? -15.083 -73.042 -16.911 0.40 153.63 ? 888  ARG A NH1 1 
ATOM   4686 N  NH2 . ARG A 1 625 ? -16.226 -74.653 -15.759 0.40 148.47 ? 888  ARG A NH2 1 
ATOM   4687 N  N   . PHE A 1 626 ? -21.063 -74.599 -20.430 0.40 136.27 ? 889  PHE A N   1 
ATOM   4688 C  CA  . PHE A 1 626 ? -22.229 -74.734 -19.514 0.40 133.89 ? 889  PHE A CA  1 
ATOM   4689 C  C   . PHE A 1 626 ? -23.397 -75.449 -20.207 0.40 131.88 ? 889  PHE A C   1 
ATOM   4690 O  O   . PHE A 1 626 ? -24.417 -75.694 -19.533 0.40 134.27 ? 889  PHE A O   1 
ATOM   4691 C  CB  . PHE A 1 626 ? -22.656 -73.363 -18.982 0.40 134.58 ? 889  PHE A CB  1 
ATOM   4692 C  CG  . PHE A 1 626 ? -21.661 -72.723 -18.047 0.40 137.70 ? 889  PHE A CG  1 
ATOM   4693 C  CD1 . PHE A 1 626 ? -21.324 -73.335 -16.848 0.40 141.17 ? 889  PHE A CD1 1 
ATOM   4694 C  CD2 . PHE A 1 626 ? -21.060 -71.514 -18.362 0.40 139.08 ? 889  PHE A CD2 1 
ATOM   4695 C  CE1 . PHE A 1 626 ? -20.405 -72.752 -15.987 0.40 144.23 ? 889  PHE A CE1 1 
ATOM   4696 C  CE2 . PHE A 1 626 ? -20.143 -70.932 -17.500 0.40 142.38 ? 889  PHE A CE2 1 
ATOM   4697 C  CZ  . PHE A 1 626 ? -19.817 -71.552 -16.315 0.40 143.86 ? 889  PHE A CZ  1 
ATOM   4698 N  N   . ARG A 1 627 ? -23.265 -75.772 -21.497 0.40 129.00 ? 890  ARG A N   1 
ATOM   4699 C  CA  . ARG A 1 627 ? -24.269 -76.571 -22.252 0.40 128.76 ? 890  ARG A CA  1 
ATOM   4700 C  C   . ARG A 1 627 ? -24.188 -78.027 -21.772 0.40 126.89 ? 890  ARG A C   1 
ATOM   4701 O  O   . ARG A 1 627 ? -23.060 -78.496 -21.497 0.40 127.00 ? 890  ARG A O   1 
ATOM   4702 C  CB  . ARG A 1 627 ? -24.039 -76.435 -23.763 0.40 128.28 ? 890  ARG A CB  1 
ATOM   4703 C  CG  . ARG A 1 627 ? -24.140 -75.004 -24.275 0.40 124.96 ? 890  ARG A CG  1 
ATOM   4704 C  CD  . ARG A 1 627 ? -24.208 -74.878 -25.787 0.40 122.91 ? 890  ARG A CD  1 
ATOM   4705 N  NE  . ARG A 1 627 ? -23.051 -75.453 -26.462 0.40 124.02 ? 890  ARG A NE  1 
ATOM   4706 C  CZ  . ARG A 1 627 ? -22.856 -75.454 -27.779 0.40 123.23 ? 890  ARG A CZ  1 
ATOM   4707 N  NH1 . ARG A 1 627 ? -23.744 -74.903 -28.592 0.40 121.64 ? 890  ARG A NH1 1 
ATOM   4708 N  NH2 . ARG A 1 627 ? -21.765 -76.006 -28.281 0.40 123.37 ? 890  ARG A NH2 1 
ATOM   4709 N  N   . ARG A 1 628 ? -25.343 -78.694 -21.647 0.40 120.79 ? 891  ARG A N   1 
ATOM   4710 C  CA  . ARG A 1 628 ? -25.465 -80.118 -21.229 0.40 115.75 ? 891  ARG A CA  1 
ATOM   4711 C  C   . ARG A 1 628 ? -25.711 -80.984 -22.470 0.40 107.94 ? 891  ARG A C   1 
ATOM   4712 O  O   . ARG A 1 628 ? -25.212 -82.104 -22.559 0.40 100.95 ? 891  ARG A O   1 
ATOM   4713 C  CB  . ARG A 1 628 ? -26.593 -80.279 -20.205 0.40 115.74 ? 891  ARG A CB  1 
ATOM   4714 C  CG  . ARG A 1 628 ? -26.763 -81.697 -19.676 0.40 115.82 ? 891  ARG A CG  1 
ATOM   4715 C  CD  . ARG A 1 628 ? -27.885 -81.809 -18.657 0.40 114.96 ? 891  ARG A CD  1 
ATOM   4716 N  NE  . ARG A 1 628 ? -28.190 -83.192 -18.302 0.40 113.51 ? 891  ARG A NE  1 
ATOM   4717 C  CZ  . ARG A 1 628 ? -27.526 -83.926 -17.408 0.40 112.98 ? 891  ARG A CZ  1 
ATOM   4718 N  NH1 . ARG A 1 628 ? -26.490 -83.426 -16.752 0.40 110.48 ? 891  ARG A NH1 1 
ATOM   4719 N  NH2 . ARG A 1 628 ? -27.902 -85.172 -17.174 0.40 112.77 ? 891  ARG A NH2 1 
HETATM 4720 ZN ZN  . ZN  B 2 .   ? -6.518  -55.257 -23.677 1.00 29.92  2 1001 ZN  A ZN  1 
HETATM 4721 ZN ZN  . ZN  C 2 .   ? -25.968 -14.533 -12.888 1.00 60.08  2 1002 ZN  A ZN  1 
HETATM 4722 O  O1  A MES D 3 .   ? -28.447 -57.385 0.720   0.25 34.78  ? 1003 MES A O1  1 
HETATM 4723 O  O1  B MES D 3 .   ? -28.208 -57.359 0.147   0.25 741.80 ? 1003 MES A O1  1 
HETATM 4724 C  C2  A MES D 3 .   ? -27.768 -57.899 1.857   0.25 31.78  ? 1003 MES A C2  1 
HETATM 4725 C  C2  B MES D 3 .   ? -27.565 -57.875 1.302   0.25 750.69 ? 1003 MES A C2  1 
HETATM 4726 C  C3  A MES D 3 .   ? -26.315 -57.500 1.851   0.25 32.50  ? 1003 MES A C3  1 
HETATM 4727 C  C3  B MES D 3 .   ? -26.069 -57.921 1.123   0.25 754.50 ? 1003 MES A C3  1 
HETATM 4728 N  N4  A MES D 3 .   ? -25.655 -57.980 0.600   0.25 30.79  ? 1003 MES A N4  1 
HETATM 4729 N  N4  B MES D 3 .   ? -25.721 -58.764 -0.062  0.25 758.05 ? 1003 MES A N4  1 
HETATM 4730 C  C5  A MES D 3 .   ? -26.405 -57.488 -0.594  0.25 31.80  ? 1003 MES A C5  1 
HETATM 4731 C  C5  B MES D 3 .   ? -26.452 -58.246 -1.259  0.25 744.14 ? 1003 MES A C5  1 
HETATM 4732 C  C6  A MES D 3 .   ? -27.862 -57.867 -0.485  0.25 33.72  ? 1003 MES A C6  1 
HETATM 4733 C  C6  B MES D 3 .   ? -27.930 -58.187 -0.972  0.25 734.34 ? 1003 MES A C6  1 
HETATM 4734 C  C7  A MES D 3 .   ? -24.221 -57.544 0.561   0.25 31.27  ? 1003 MES A C7  1 
HETATM 4735 C  C7  B MES D 3 .   ? -24.240 -58.814 -0.303  0.25 772.19 ? 1003 MES A C7  1 
HETATM 4736 C  C8  A MES D 3 .   ? -23.334 -58.501 -0.209  0.25 31.35  ? 1003 MES A C8  1 
HETATM 4737 C  C8  B MES D 3 .   ? -23.485 -57.684 0.368   0.25 786.55 ? 1003 MES A C8  1 
HETATM 4738 S  S   A MES D 3 .   ? -21.607 -58.105 -0.022  0.25 32.89  ? 1003 MES A S   1 
HETATM 4739 S  S   B MES D 3 .   ? -21.734 -57.986 0.426   0.25 806.74 ? 1003 MES A S   1 
HETATM 4740 O  O1S A MES D 3 .   ? -21.293 -58.345 1.350   0.25 25.65  ? 1003 MES A O1S 1 
HETATM 4741 O  O1S B MES D 3 .   ? -21.573 -59.409 0.314   0.25 814.30 ? 1003 MES A O1S 1 
HETATM 4742 O  O2S A MES D 3 .   ? -20.929 -58.941 -0.973  0.25 29.99  ? 1003 MES A O2S 1 
HETATM 4743 O  O2S B MES D 3 .   ? -21.170 -57.277 -0.687  0.25 801.59 ? 1003 MES A O2S 1 
HETATM 4744 O  O3S A MES D 3 .   ? -21.504 -56.701 -0.394  0.25 29.93  ? 1003 MES A O3S 1 
HETATM 4745 O  O3S B MES D 3 .   ? -21.283 -57.478 1.691   0.25 811.53 ? 1003 MES A O3S 1 
HETATM 4746 S  S   . DMS E 4 .   ? -26.852 -61.944 -21.069 1.00 59.88  ? 1004 DMS A S   1 
HETATM 4747 O  O   . DMS E 4 .   ? -26.808 -62.545 -22.482 1.00 61.71  ? 1004 DMS A O   1 
HETATM 4748 C  C1  . DMS E 4 .   ? -28.090 -60.681 -21.143 1.00 62.28  ? 1004 DMS A C1  1 
HETATM 4749 C  C2  . DMS E 4 .   ? -25.421 -60.879 -20.980 1.00 54.92  ? 1004 DMS A C2  1 
HETATM 4750 S  S   . DMS F 4 .   ? -16.098 -69.499 -28.726 0.40 104.17 ? 1005 DMS A S   1 
HETATM 4751 O  O   . DMS F 4 .   ? -16.643 -68.100 -28.630 0.40 98.53  ? 1005 DMS A O   1 
HETATM 4752 C  C1  . DMS F 4 .   ? -16.710 -70.367 -27.303 0.40 102.41 ? 1005 DMS A C1  1 
HETATM 4753 C  C2  . DMS F 4 .   ? -14.395 -69.401 -28.240 0.40 102.45 ? 1005 DMS A C2  1 
HETATM 4754 S  S   . DMS G 4 .   ? -22.769 -47.998 -15.611 0.50 80.14  ? 1006 DMS A S   1 
HETATM 4755 O  O   . DMS G 4 .   ? -24.213 -47.588 -15.534 0.50 81.03  ? 1006 DMS A O   1 
HETATM 4756 C  C1  . DMS G 4 .   ? -21.939 -46.736 -16.546 0.50 80.63  ? 1006 DMS A C1  1 
HETATM 4757 C  C2  . DMS G 4 .   ? -22.677 -49.282 -16.831 0.50 78.30  ? 1006 DMS A C2  1 
HETATM 4758 P  P   . PO4 H 5 .   ? -3.993  -39.415 -23.767 1.00 74.22  ? 1007 PO4 A P   1 
HETATM 4759 O  O1  . PO4 H 5 .   ? -2.639  -40.168 -23.220 1.00 46.66  ? 1007 PO4 A O1  1 
HETATM 4760 O  O2  . PO4 H 5 .   ? -3.663  -37.960 -24.360 1.00 41.16  ? 1007 PO4 A O2  1 
HETATM 4761 O  O3  . PO4 H 5 .   ? -4.770  -40.257 -24.899 1.00 45.95  ? 1007 PO4 A O3  1 
HETATM 4762 O  O4  . PO4 H 5 .   ? -4.847  -39.306 -22.580 1.00 54.42  ? 1007 PO4 A O4  1 
HETATM 4763 P  P   . PO4 I 5 .   ? -18.230 -9.590  -29.110 1.00 130.42 ? 1008 PO4 A P   1 
HETATM 4764 O  O1  . PO4 I 5 .   ? -17.463 -9.802  -27.771 1.00 91.89  ? 1008 PO4 A O1  1 
HETATM 4765 O  O2  . PO4 I 5 .   ? -17.248 -9.500  -30.288 1.00 101.05 ? 1008 PO4 A O2  1 
HETATM 4766 O  O3  . PO4 I 5 .   ? -19.199 -10.769 -29.343 1.00 104.72 ? 1008 PO4 A O3  1 
HETATM 4767 O  O4  . PO4 I 5 .   ? -19.035 -8.284  -29.040 1.00 116.64 ? 1008 PO4 A O4  1 
HETATM 4768 C  C1  . PEG J 6 .   ? -16.535 -43.207 -41.086 1.00 80.22  ? 1009 PEG A C1  1 
HETATM 4769 O  O1  . PEG J 6 .   ? -17.817 -43.558 -40.598 1.00 69.14  ? 1009 PEG A O1  1 
HETATM 4770 C  C2  . PEG J 6 .   ? -16.270 -43.775 -42.439 1.00 80.45  ? 1009 PEG A C2  1 
HETATM 4771 O  O2  . PEG J 6 .   ? -16.285 -45.195 -42.350 1.00 80.05  ? 1009 PEG A O2  1 
HETATM 4772 C  C3  . PEG J 6 .   ? -16.263 -45.849 -43.617 1.00 78.40  ? 1009 PEG A C3  1 
HETATM 4773 C  C4  . PEG J 6 .   ? -15.464 -47.117 -43.513 1.00 83.31  ? 1009 PEG A C4  1 
HETATM 4774 O  O4  . PEG J 6 .   ? -15.807 -48.084 -44.494 1.00 84.54  ? 1009 PEG A O4  1 
HETATM 4775 N  N1  . K07 K 7 .   ? -8.209  -70.877 -21.421 0.40 49.90  ? 1010 K07 A N1  1 
HETATM 4776 C  C4  . K07 K 7 .   ? -3.367  -70.572 -20.979 0.40 50.71  ? 1010 K07 A C4  1 
HETATM 4777 C  C5  . K07 K 7 .   ? -4.802  -70.601 -19.242 0.40 50.21  ? 1010 K07 A C5  1 
HETATM 4778 C  C6  . K07 K 7 .   ? -8.394  -71.448 -20.229 0.40 52.36  ? 1010 K07 A C6  1 
HETATM 4779 C  C7  . K07 K 7 .   ? -9.238  -70.159 -21.861 0.40 47.34  ? 1010 K07 A C7  1 
HETATM 4780 C  C8  . K07 K 7 .   ? -10.563 -70.558 -20.086 0.40 54.32  ? 1010 K07 A C8  1 
HETATM 4781 N  N   . K07 K 7 .   ? -7.327  -72.114 -19.714 0.40 50.31  ? 1010 K07 A N   1 
HETATM 4782 C  C   . K07 K 7 .   ? -7.302  -72.660 -18.371 0.40 48.66  ? 1010 K07 A C   1 
HETATM 4783 O  O   . K07 K 7 .   ? -4.410  -69.831 -20.352 0.40 51.31  ? 1010 K07 A O   1 
HETATM 4784 C  C1  . K07 K 7 .   ? -6.128  -72.275 -20.521 0.40 50.64  ? 1010 K07 A C1  1 
HETATM 4785 C  C2  . K07 K 7 .   ? -4.856  -72.021 -19.770 0.40 51.60  ? 1010 K07 A C2  1 
HETATM 4786 C  C3  . K07 K 7 .   ? -3.638  -72.042 -20.700 0.40 51.51  ? 1010 K07 A C3  1 
HETATM 4787 C  C9  . K07 K 7 .   ? -9.571  -71.325 -19.499 0.40 55.70  ? 1010 K07 A C9  1 
HETATM 4788 N  N2  . K07 K 7 .   ? -10.411 -69.965 -21.269 0.40 50.72  ? 1010 K07 A N2  1 
HETATM 4789 CL CL  . K07 K 7 .   ? -9.591  -71.517 -17.776 0.40 68.61  ? 1010 K07 A CL  1 
HETATM 4790 O  O   . HOH L 8 .   ? -15.498 -22.005 -18.704 1.00 46.41  ? 1101 HOH A O   1 
HETATM 4791 O  O   . HOH L 8 .   ? 0.237   -64.606 -19.131 1.00 44.96  ? 1102 HOH A O   1 
HETATM 4792 O  O   . HOH L 8 .   ? -5.384  -58.531 -29.806 1.00 47.38  ? 1103 HOH A O   1 
HETATM 4793 O  O   . HOH L 8 .   ? -13.759 -48.958 -29.724 0.50 64.74  ? 1104 HOH A O   1 
HETATM 4794 O  O   . HOH L 8 .   ? -32.516 -60.455 -18.721 1.00 45.54  ? 1105 HOH A O   1 
HETATM 4795 O  O   . HOH L 8 .   ? -2.069  -41.445 -21.334 1.00 57.57  ? 1106 HOH A O   1 
HETATM 4796 O  O   . HOH L 8 .   ? -6.387  -12.137 -21.681 1.00 66.22  ? 1107 HOH A O   1 
HETATM 4797 O  O   . HOH L 8 .   ? -12.356 -69.790 -22.588 0.40 45.61  ? 1108 HOH A O   1 
HETATM 4798 O  O   . HOH L 8 .   ? -7.754  -48.912 0.742   1.00 60.83  ? 1109 HOH A O   1 
HETATM 4799 O  O   . HOH L 8 .   ? -40.242 -61.243 -11.258 1.00 35.56  ? 1110 HOH A O   1 
HETATM 4800 O  O   . HOH L 8 .   ? -32.669 -52.017 -27.003 1.00 51.42  ? 1111 HOH A O   1 
HETATM 4801 O  O   . HOH L 8 .   ? 1.105   -21.424 -45.028 1.00 58.41  ? 1112 HOH A O   1 
HETATM 4802 O  O   . HOH L 8 .   ? -22.342 -53.270 -46.690 1.00 57.91  ? 1113 HOH A O   1 
HETATM 4803 O  O   . HOH L 8 .   ? -14.549 -17.231 -35.875 1.00 47.63  ? 1114 HOH A O   1 
HETATM 4804 O  O   . HOH L 8 .   ? -31.858 -57.400 -21.792 1.00 43.22  ? 1115 HOH A O   1 
HETATM 4805 O  O   . HOH L 8 .   ? -38.166 -67.358 -8.362  1.00 50.10  ? 1116 HOH A O   1 
HETATM 4806 O  O   . HOH L 8 .   ? -6.899  -20.265 -26.628 1.00 48.96  ? 1117 HOH A O   1 
HETATM 4807 O  O   . HOH L 8 .   ? -28.849 -62.785 -25.306 1.00 42.84  ? 1118 HOH A O   1 
HETATM 4808 O  O   . HOH L 8 .   ? -21.879 -42.130 0.664   1.00 73.28  ? 1119 HOH A O   1 
HETATM 4809 O  O   . HOH L 8 .   ? -22.117 -74.295 -11.710 1.00 33.66  ? 1120 HOH A O   1 
HETATM 4810 O  O   . HOH L 8 .   ? -4.288  -54.536 -11.921 1.00 53.77  ? 1121 HOH A O   1 
HETATM 4811 O  O   . HOH L 8 .   ? -40.496 -57.613 -6.647  1.00 62.47  ? 1122 HOH A O   1 
HETATM 4812 O  O   . HOH L 8 .   ? -8.190  -61.979 -34.242 0.40 50.28  ? 1123 HOH A O   1 
HETATM 4813 O  O   . HOH L 8 .   ? -24.548 -69.207 -27.753 1.00 46.64  ? 1124 HOH A O   1 
HETATM 4814 O  O   . HOH L 8 .   ? -32.800 -63.464 -15.016 1.00 35.46  ? 1125 HOH A O   1 
HETATM 4815 O  O   . HOH L 8 .   ? -13.460 -12.836 -26.741 1.00 58.86  ? 1126 HOH A O   1 
HETATM 4816 O  O   . HOH L 8 .   ? -22.199 -10.078 -9.059  1.00 58.43  ? 1127 HOH A O   1 
HETATM 4817 O  O   . HOH L 8 .   ? 1.668   -32.269 -38.628 1.00 35.98  ? 1128 HOH A O   1 
HETATM 4818 O  O   . HOH L 8 .   ? -4.389  -53.696 -28.009 1.00 39.88  ? 1129 HOH A O   1 
HETATM 4819 O  O   . HOH L 8 .   ? 6.766   -27.329 -16.674 1.00 63.24  ? 1130 HOH A O   1 
HETATM 4820 O  O   . HOH L 8 .   ? -0.399  -10.843 -29.208 1.00 54.22  ? 1131 HOH A O   1 
HETATM 4821 O  O   . HOH L 8 .   ? -34.480 -20.116 -23.577 1.00 53.31  ? 1132 HOH A O   1 
HETATM 4822 O  O   . HOH L 8 .   ? -15.643 -65.723 -33.862 1.00 54.75  ? 1133 HOH A O   1 
HETATM 4823 O  O   . HOH L 8 .   ? -7.542  -42.337 -42.725 1.00 66.61  ? 1134 HOH A O   1 
HETATM 4824 O  O   . HOH L 8 .   ? -30.042 -55.636 -35.533 0.40 46.47  ? 1135 HOH A O   1 
HETATM 4825 O  O   . HOH L 8 .   ? -23.252 -64.958 -38.773 1.00 55.72  ? 1136 HOH A O   1 
HETATM 4826 O  O   . HOH L 8 .   ? -32.961 -48.945 -18.757 1.00 56.10  ? 1137 HOH A O   1 
HETATM 4827 O  O   . HOH L 8 .   ? -9.344  -21.404 -26.856 1.00 44.94  ? 1138 HOH A O   1 
HETATM 4828 O  O   . HOH L 8 .   ? -22.632 -65.755 -23.707 1.00 48.60  ? 1139 HOH A O   1 
HETATM 4829 O  O   . HOH L 8 .   ? -22.895 -21.000 -37.582 1.00 49.96  ? 1140 HOH A O   1 
HETATM 4830 O  O   . HOH L 8 .   ? -12.756 -42.582 -38.900 1.00 47.07  ? 1141 HOH A O   1 
HETATM 4831 O  O   . HOH L 8 .   ? 5.802   -40.243 -21.432 1.00 68.82  ? 1142 HOH A O   1 
HETATM 4832 O  O   . HOH L 8 .   ? 5.867   -31.351 -19.104 1.00 44.16  ? 1143 HOH A O   1 
HETATM 4833 O  O   . HOH L 8 .   ? 0.130   -32.744 -27.561 1.00 36.15  ? 1144 HOH A O   1 
HETATM 4834 O  O   . HOH L 8 .   ? -39.452 -55.379 -6.407  1.00 51.98  ? 1145 HOH A O   1 
HETATM 4835 O  O   . HOH L 8 .   ? 6.736   -35.058 -43.437 1.00 59.71  ? 1146 HOH A O   1 
HETATM 4836 O  O   . HOH L 8 .   ? 5.882   -32.676 -37.683 1.00 44.86  ? 1147 HOH A O   1 
HETATM 4837 O  O   . HOH L 8 .   ? -18.932 -65.247 -7.098  1.00 28.24  ? 1148 HOH A O   1 
HETATM 4838 O  O   . HOH L 8 .   ? -20.779 -47.161 -10.189 1.00 54.79  ? 1149 HOH A O   1 
HETATM 4839 O  O   . HOH L 8 .   ? -24.749 -14.057 -4.577  1.00 57.55  ? 1150 HOH A O   1 
HETATM 4840 O  O   . HOH L 8 .   ? -16.483 -32.481 -18.077 1.00 60.76  ? 1151 HOH A O   1 
HETATM 4841 O  O   . HOH L 8 .   ? -7.434  -47.366 -17.973 1.00 41.05  ? 1152 HOH A O   1 
HETATM 4842 O  O   . HOH L 8 .   ? -34.746 -62.844 0.571   1.00 31.38  ? 1153 HOH A O   1 
HETATM 4843 O  O   . HOH L 8 .   ? -12.427 -58.132 -0.000  0.50 25.44  ? 1154 HOH A O   1 
HETATM 4844 O  O   . HOH L 8 .   ? -15.077 -54.237 -39.610 1.00 51.67  ? 1155 HOH A O   1 
HETATM 4845 O  O   . HOH L 8 .   ? -16.038 -11.855 -29.259 1.00 48.87  ? 1156 HOH A O   1 
HETATM 4846 O  O   . HOH L 8 .   ? -3.857  -61.575 -15.472 1.00 42.64  ? 1157 HOH A O   1 
HETATM 4847 O  O   . HOH L 8 .   ? -13.654 -74.424 -14.007 1.00 55.88  ? 1158 HOH A O   1 
HETATM 4848 O  O   . HOH L 8 .   ? -5.537  -59.998 -0.798  1.00 48.74  ? 1159 HOH A O   1 
HETATM 4849 O  O   . HOH L 8 .   ? -26.564 -25.557 -33.097 1.00 33.60  ? 1160 HOH A O   1 
HETATM 4850 O  O   . HOH L 8 .   ? -27.169 -56.811 -40.021 1.00 58.23  ? 1161 HOH A O   1 
HETATM 4851 O  O   . HOH L 8 .   ? -5.074  -48.706 -28.627 1.00 36.68  ? 1162 HOH A O   1 
HETATM 4852 O  O   . HOH L 8 .   ? 2.711   -39.583 -26.620 1.00 37.90  ? 1163 HOH A O   1 
HETATM 4853 O  O   . HOH L 8 .   ? -4.393  -65.511 -14.949 1.00 41.15  ? 1164 HOH A O   1 
HETATM 4854 O  O   . HOH L 8 .   ? 5.418   -30.071 -21.254 1.00 34.21  ? 1165 HOH A O   1 
HETATM 4855 O  O   . HOH L 8 .   ? -39.122 -60.984 -4.405  1.00 48.85  ? 1166 HOH A O   1 
HETATM 4856 O  O   . HOH L 8 .   ? -10.741 -48.090 -38.986 1.00 32.05  ? 1167 HOH A O   1 
HETATM 4857 O  O   . HOH L 8 .   ? -5.839  -58.532 -36.818 1.00 57.60  ? 1168 HOH A O   1 
HETATM 4858 O  O   . HOH L 8 .   ? -29.259 -50.390 -29.944 1.00 64.59  ? 1169 HOH A O   1 
HETATM 4859 O  O   . HOH L 8 .   ? -15.066 -70.689 -18.195 0.40 35.99  ? 1170 HOH A O   1 
HETATM 4860 O  O   . HOH L 8 .   ? -4.026  -57.520 -9.807  1.00 47.86  ? 1171 HOH A O   1 
HETATM 4861 O  O   . HOH L 8 .   ? -8.739  -26.047 -44.153 1.00 47.47  ? 1172 HOH A O   1 
HETATM 4862 O  O   . HOH L 8 .   ? -3.302  -20.173 -22.933 1.00 46.01  ? 1173 HOH A O   1 
HETATM 4863 O  O   . HOH L 8 .   ? -26.416 -30.484 -23.123 1.00 53.63  ? 1174 HOH A O   1 
HETATM 4864 O  O   . HOH L 8 .   ? -32.675 -70.919 -8.991  1.00 59.10  ? 1175 HOH A O   1 
HETATM 4865 O  O   . HOH L 8 .   ? 4.238   -28.861 -43.866 1.00 50.65  ? 1176 HOH A O   1 
HETATM 4866 O  O   . HOH L 8 .   ? -21.615 -66.059 -4.527  1.00 52.09  ? 1177 HOH A O   1 
HETATM 4867 O  O   . HOH L 8 .   ? -28.920 -45.745 2.661   1.00 59.81  ? 1178 HOH A O   1 
HETATM 4868 O  O   . HOH L 8 .   ? -35.641 -66.523 -0.678  1.00 44.20  ? 1179 HOH A O   1 
HETATM 4869 O  O   . HOH L 8 .   ? 4.728   -16.491 -21.106 1.00 57.73  ? 1180 HOH A O   1 
HETATM 4870 O  O   . HOH L 8 .   ? 11.358  -34.774 -32.725 1.00 43.08  ? 1181 HOH A O   1 
HETATM 4871 O  O   . HOH L 8 .   ? -0.018  -31.215 -22.740 1.00 34.19  ? 1182 HOH A O   1 
HETATM 4872 O  O   . HOH L 8 .   ? 5.620   -38.796 -24.233 1.00 45.94  ? 1183 HOH A O   1 
HETATM 4873 O  O   . HOH L 8 .   ? -12.802 -53.489 -40.568 1.00 59.44  ? 1184 HOH A O   1 
HETATM 4874 O  O   . HOH L 8 .   ? -18.036 -62.127 -3.035  1.00 30.70  ? 1185 HOH A O   1 
HETATM 4875 O  O   . HOH L 8 .   ? 10.516  -38.752 -29.584 1.00 63.53  ? 1186 HOH A O   1 
HETATM 4876 O  O   . HOH L 8 .   ? -14.907 -34.716 -28.736 1.00 30.53  ? 1187 HOH A O   1 
HETATM 4877 O  O   . HOH L 8 .   ? -12.215 -36.808 -39.378 1.00 34.84  ? 1188 HOH A O   1 
HETATM 4878 O  O   . HOH L 8 .   ? -14.719 -64.038 -0.493  1.00 35.33  ? 1189 HOH A O   1 
HETATM 4879 O  O   . HOH L 8 .   ? -20.879 -49.995 0.998   1.00 55.36  ? 1190 HOH A O   1 
HETATM 4880 O  O   . HOH L 8 .   ? -3.120  -55.144 -17.983 1.00 37.37  ? 1191 HOH A O   1 
HETATM 4881 O  O   . HOH L 8 .   ? -41.224 -58.132 -9.925  0.50 39.26  ? 1192 HOH A O   1 
HETATM 4882 O  O   . HOH L 8 .   ? -28.418 -49.791 0.243   1.00 42.78  ? 1193 HOH A O   1 
HETATM 4883 O  O   . HOH L 8 .   ? -22.431 -50.927 -9.137  1.00 37.26  ? 1194 HOH A O   1 
HETATM 4884 O  O   . HOH L 8 .   ? 4.202   -26.604 -29.020 1.00 42.00  ? 1195 HOH A O   1 
HETATM 4885 O  O   . HOH L 8 .   ? -29.854 -50.337 -27.343 1.00 54.29  ? 1196 HOH A O   1 
HETATM 4886 O  O   . HOH L 8 .   ? 1.705   -19.833 -19.365 1.00 69.95  ? 1197 HOH A O   1 
HETATM 4887 O  O   . HOH L 8 .   ? -31.803 -60.089 -15.865 1.00 36.97  ? 1198 HOH A O   1 
HETATM 4888 O  O   . HOH L 8 .   ? -22.544 -27.469 -18.762 1.00 58.62  ? 1199 HOH A O   1 
HETATM 4889 O  O   . HOH L 8 .   ? -2.534  -57.854 -27.293 1.00 34.02  ? 1200 HOH A O   1 
HETATM 4890 O  O   . HOH L 8 .   ? -19.230 -20.544 -40.229 1.00 50.29  ? 1201 HOH A O   1 
HETATM 4891 O  O   . HOH L 8 .   ? -10.946 -62.373 -18.805 1.00 26.19  ? 1202 HOH A O   1 
HETATM 4892 O  O   . HOH L 8 .   ? -13.777 -51.158 -42.925 1.00 61.01  ? 1203 HOH A O   1 
HETATM 4893 O  O   . HOH L 8 .   ? -22.008 -31.569 -39.463 1.00 53.56  ? 1204 HOH A O   1 
HETATM 4894 O  O   . HOH L 8 .   ? -6.953  -60.674 -30.725 0.40 66.25  ? 1205 HOH A O   1 
HETATM 4895 O  O   . HOH L 8 .   ? -8.449  -16.986 -38.732 1.00 51.92  ? 1206 HOH A O   1 
HETATM 4896 O  O   . HOH L 8 .   ? -21.257 -49.294 -34.840 1.00 52.23  ? 1207 HOH A O   1 
HETATM 4897 O  O   . HOH L 8 .   ? -19.537 -17.227 -10.738 1.00 54.47  ? 1208 HOH A O   1 
HETATM 4898 O  O   . HOH L 8 .   ? -29.404 -33.643 -28.247 1.00 58.39  ? 1209 HOH A O   1 
HETATM 4899 O  O   . HOH L 8 .   ? -27.980 -18.408 -35.048 1.00 50.93  ? 1210 HOH A O   1 
HETATM 4900 O  O   . HOH L 8 .   ? -19.385 -27.251 -39.777 1.00 33.59  ? 1211 HOH A O   1 
HETATM 4901 O  O   . HOH L 8 .   ? -26.488 -71.391 -3.551  1.00 49.87  ? 1212 HOH A O   1 
HETATM 4902 O  O   . HOH L 8 .   ? -38.308 -60.815 -14.316 1.00 46.52  ? 1213 HOH A O   1 
HETATM 4903 O  O   . HOH L 8 .   ? -3.591  -54.921 -36.297 1.00 59.62  ? 1214 HOH A O   1 
HETATM 4904 O  O   . HOH L 8 .   ? -8.443  -64.912 -6.833  1.00 40.13  ? 1215 HOH A O   1 
HETATM 4905 O  O   . HOH L 8 .   ? 10.549  -26.813 -28.853 1.00 48.72  ? 1216 HOH A O   1 
HETATM 4906 O  O   . HOH L 8 .   ? -23.076 -27.466 -24.490 1.00 50.10  ? 1217 HOH A O   1 
HETATM 4907 O  O   . HOH L 8 .   ? 1.056   -41.555 -24.206 1.00 49.03  ? 1218 HOH A O   1 
HETATM 4908 O  O   . HOH L 8 .   ? -9.139  -59.080 -13.317 1.00 34.45  ? 1219 HOH A O   1 
HETATM 4909 O  O   . HOH L 8 .   ? -20.780 -31.608 -29.172 1.00 39.17  ? 1220 HOH A O   1 
HETATM 4910 O  O   . HOH L 8 .   ? -28.035 -47.130 -0.084  1.00 54.67  ? 1221 HOH A O   1 
HETATM 4911 O  O   . HOH L 8 .   ? -19.057 -69.719 -8.211  1.00 31.62  ? 1222 HOH A O   1 
HETATM 4912 O  O   . HOH L 8 .   ? -27.882 -23.037 -26.260 1.00 36.45  ? 1223 HOH A O   1 
HETATM 4913 O  O   . HOH L 8 .   ? 7.763   -43.007 -35.957 1.00 54.31  ? 1224 HOH A O   1 
HETATM 4914 O  O   . HOH L 8 .   ? -29.002 -17.510 -20.563 1.00 52.14  ? 1225 HOH A O   1 
HETATM 4915 O  O   . HOH L 8 .   ? -14.141 -52.203 -5.806  1.00 35.84  ? 1226 HOH A O   1 
HETATM 4916 O  O   . HOH L 8 .   ? -19.902 -37.868 -36.487 1.00 37.19  ? 1227 HOH A O   1 
HETATM 4917 O  O   . HOH L 8 .   ? -5.698  -59.267 -11.992 1.00 48.43  ? 1228 HOH A O   1 
HETATM 4918 O  O   . HOH L 8 .   ? -17.008 -51.837 -15.439 1.00 26.54  ? 1229 HOH A O   1 
HETATM 4919 O  O   . HOH L 8 .   ? 9.049   -24.057 -35.717 1.00 62.92  ? 1230 HOH A O   1 
HETATM 4920 O  O   . HOH L 8 .   ? -20.459 -67.315 -25.332 1.00 37.80  ? 1231 HOH A O   1 
HETATM 4921 O  O   . HOH L 8 .   ? -14.039 -49.262 -32.178 0.50 31.08  ? 1232 HOH A O   1 
HETATM 4922 O  O   . HOH L 8 .   ? -4.126  -22.946 -24.850 1.00 42.09  ? 1233 HOH A O   1 
HETATM 4923 O  O   . HOH L 8 .   ? -25.050 -53.440 -1.953  1.00 36.13  ? 1234 HOH A O   1 
HETATM 4924 O  O   . HOH L 8 .   ? -5.714  -33.047 -17.275 1.00 53.36  ? 1235 HOH A O   1 
HETATM 4925 O  O   . HOH L 8 .   ? -29.482 -63.824 -33.910 0.40 45.99  ? 1236 HOH A O   1 
HETATM 4926 O  O   . HOH L 8 .   ? -5.847  -50.367 -18.873 1.00 36.81  ? 1237 HOH A O   1 
HETATM 4927 O  O   . HOH L 8 .   ? -13.690 -53.574 -1.576  1.00 35.99  ? 1238 HOH A O   1 
HETATM 4928 O  O   . HOH L 8 .   ? -0.018  -55.037 -33.373 1.00 54.02  ? 1239 HOH A O   1 
HETATM 4929 O  O   . HOH L 8 .   ? -22.873 -33.510 -36.786 1.00 39.02  ? 1240 HOH A O   1 
HETATM 4930 O  O   . HOH L 8 .   ? -37.044 -50.272 -5.491  1.00 48.71  ? 1241 HOH A O   1 
HETATM 4931 O  O   . HOH L 8 .   ? -32.673 -14.199 -9.549  1.00 60.55  ? 1242 HOH A O   1 
HETATM 4932 O  O   . HOH L 8 .   ? -0.484  -35.714 -27.802 1.00 41.92  ? 1243 HOH A O   1 
HETATM 4933 O  O   . HOH L 8 .   ? -14.282 -56.467 -1.524  1.00 27.38  ? 1244 HOH A O   1 
HETATM 4934 O  O   . HOH L 8 .   ? 8.218   -48.758 -29.577 0.40 66.22  ? 1245 HOH A O   1 
HETATM 4935 O  O   . HOH L 8 .   ? 7.624   -22.095 -23.756 1.00 57.44  ? 1246 HOH A O   1 
HETATM 4936 O  O   . HOH L 8 .   ? -9.059  -37.136 -19.067 1.00 51.44  ? 1247 HOH A O   1 
HETATM 4937 O  O   . HOH L 8 .   ? -20.465 -29.210 -24.947 1.00 44.22  ? 1248 HOH A O   1 
HETATM 4938 O  O   . HOH L 8 .   ? -12.460 -66.848 -29.759 1.00 39.30  ? 1249 HOH A O   1 
HETATM 4939 O  O   . HOH L 8 .   ? -18.216 -69.364 -24.686 1.00 42.28  ? 1250 HOH A O   1 
HETATM 4940 O  O   . HOH L 8 .   ? -27.840 -16.814 -32.078 1.00 45.78  ? 1251 HOH A O   1 
HETATM 4941 O  O   . HOH L 8 .   ? -35.828 -54.095 -3.282  1.00 40.39  ? 1252 HOH A O   1 
HETATM 4942 O  O   . HOH L 8 .   ? -9.045  -64.128 -31.363 0.40 42.50  ? 1253 HOH A O   1 
HETATM 4943 O  O   . HOH L 8 .   ? -20.034 -46.054 -25.148 1.00 45.94  ? 1254 HOH A O   1 
HETATM 4944 O  O   . HOH L 8 .   ? -38.912 -54.870 -18.894 1.00 51.55  ? 1255 HOH A O   1 
HETATM 4945 O  O   . HOH L 8 .   ? -17.779 -71.712 -22.847 1.00 63.30  ? 1256 HOH A O   1 
HETATM 4946 O  O   . HOH L 8 .   ? 2.761   -64.453 -20.682 1.00 26.52  ? 1257 HOH A O   1 
HETATM 4947 O  O   . HOH L 8 .   ? -17.925 -65.773 -36.438 1.00 54.13  ? 1258 HOH A O   1 
HETATM 4948 O  O   . HOH L 8 .   ? -29.878 -59.532 -19.856 1.00 38.40  ? 1259 HOH A O   1 
HETATM 4949 O  O   . HOH L 8 .   ? -27.302 -15.483 -19.632 1.00 49.27  ? 1260 HOH A O   1 
HETATM 4950 O  O   . HOH L 8 .   ? -14.897 -54.204 -4.002  1.00 30.36  ? 1261 HOH A O   1 
HETATM 4951 O  O   . HOH L 8 .   ? -5.749  -49.011 -21.192 1.00 37.44  ? 1262 HOH A O   1 
HETATM 4952 O  O   . HOH L 8 .   ? 4.988   -43.995 -39.262 0.50 46.97  ? 1263 HOH A O   1 
HETATM 4953 O  O   . HOH L 8 .   ? -1.247  -69.511 -16.932 0.40 24.76  ? 1264 HOH A O   1 
HETATM 4954 O  O   . HOH L 8 .   ? -30.624 -44.377 -16.189 0.50 54.49  ? 1265 HOH A O   1 
HETATM 4955 O  O   . HOH L 8 .   ? -15.698 -9.146  -32.786 1.00 60.00  ? 1266 HOH A O   1 
HETATM 4956 O  O   . HOH L 8 .   ? -3.955  -70.939 -8.734  1.00 42.99  ? 1267 HOH A O   1 
HETATM 4957 O  O   . HOH L 8 .   ? -28.097 -49.121 -31.478 1.00 67.74  ? 1268 HOH A O   1 
HETATM 4958 O  O   . HOH L 8 .   ? -15.092 -48.599 -18.627 1.00 44.17  ? 1269 HOH A O   1 
HETATM 4959 O  O   . HOH L 8 .   ? -30.113 -60.790 -23.053 1.00 44.59  ? 1270 HOH A O   1 
HETATM 4960 O  O   . HOH L 8 .   ? -6.520  -37.203 -20.662 1.00 52.76  ? 1271 HOH A O   1 
HETATM 4961 O  O   . HOH L 8 .   ? -14.128 -44.773 -3.780  1.00 69.12  ? 1272 HOH A O   1 
HETATM 4962 O  O   . HOH L 8 .   ? -17.304 -57.272 -43.703 1.00 40.44  ? 1273 HOH A O   1 
HETATM 4963 O  O   . HOH L 8 .   ? -33.637 -57.318 -19.659 1.00 59.43  ? 1274 HOH A O   1 
HETATM 4964 O  O   . HOH L 8 .   ? -21.396 -41.324 -35.187 0.50 33.51  ? 1275 HOH A O   1 
HETATM 4965 O  O   . HOH L 8 .   ? -13.342 -68.522 -6.066  1.00 49.34  ? 1276 HOH A O   1 
HETATM 4966 O  O   . HOH L 8 .   ? -23.311 -49.355 -42.176 1.00 46.53  ? 1277 HOH A O   1 
HETATM 4967 O  O   . HOH L 8 .   ? -39.667 -64.443 -2.040  1.00 59.10  ? 1278 HOH A O   1 
HETATM 4968 O  O   . HOH L 8 .   ? -19.790 -38.349 -26.030 1.00 72.44  ? 1279 HOH A O   1 
HETATM 4969 O  O   . HOH L 8 .   ? 0.773   -38.773 -21.011 1.00 53.34  ? 1280 HOH A O   1 
HETATM 4970 O  O   . HOH L 8 .   ? -7.245  -57.362 -0.869  1.00 54.54  ? 1281 HOH A O   1 
HETATM 4971 O  O   . HOH L 8 .   ? -9.679  -61.732 -41.932 1.00 79.00  ? 1282 HOH A O   1 
HETATM 4972 O  O   . HOH L 8 .   ? -12.771 -75.390 -26.143 1.00 67.36  ? 1283 HOH A O   1 
HETATM 4973 O  O   . HOH L 8 .   ? -11.540 -41.086 -19.721 1.00 58.27  ? 1284 HOH A O   1 
HETATM 4974 O  O   . HOH L 8 .   ? -4.169  -56.988 -13.382 1.00 55.16  ? 1285 HOH A O   1 
HETATM 4975 O  O   . HOH L 8 .   ? -36.179 -58.700 -20.753 1.00 68.97  ? 1286 HOH A O   1 
HETATM 4976 O  O   . HOH L 8 .   ? 8.631   -40.681 -31.406 1.00 49.48  ? 1287 HOH A O   1 
HETATM 4977 O  O   . HOH L 8 .   ? -12.191 -44.037 -16.180 1.00 59.12  ? 1288 HOH A O   1 
HETATM 4978 O  O   . HOH L 8 .   ? 8.409   -44.734 -30.346 0.50 60.15  ? 1289 HOH A O   1 
HETATM 4979 O  O   . HOH L 8 .   ? -15.498 -54.748 -43.761 1.00 56.71  ? 1290 HOH A O   1 
HETATM 4980 O  O   . HOH L 8 .   ? -4.121  -52.794 -38.363 1.00 64.40  ? 1291 HOH A O   1 
HETATM 4981 O  O   . HOH L 8 .   ? -14.755 -68.822 -19.901 1.00 49.24  ? 1292 HOH A O   1 
HETATM 4982 O  O   . HOH L 8 .   ? -37.460 -52.518 -12.875 1.00 36.77  ? 1293 HOH A O   1 
HETATM 4983 O  O   . HOH L 8 .   ? 3.654   -31.404 -36.874 1.00 34.99  ? 1294 HOH A O   1 
HETATM 4984 O  O   . HOH L 8 .   ? -33.713 -46.955 -15.747 1.00 66.57  ? 1295 HOH A O   1 
HETATM 4985 O  O   . HOH L 8 .   ? -11.739 -71.910 -15.618 1.00 30.61  ? 1296 HOH A O   1 
HETATM 4986 O  O   . HOH L 8 .   ? 9.913   -38.228 -38.966 1.00 55.82  ? 1297 HOH A O   1 
HETATM 4987 O  O   . HOH L 8 .   ? -17.407 -41.632 -37.042 1.00 48.16  ? 1298 HOH A O   1 
HETATM 4988 O  O   . HOH L 8 .   ? -4.763  -56.403 -31.571 1.00 35.04  ? 1299 HOH A O   1 
HETATM 4989 O  O   . HOH L 8 .   ? 0.419   -70.606 -21.205 1.00 39.54  ? 1300 HOH A O   1 
HETATM 4990 O  O   . HOH L 8 .   ? -11.139 -46.303 3.828   1.00 56.78  ? 1301 HOH A O   1 
HETATM 4991 O  O   . HOH L 8 .   ? -31.244 -71.925 -13.421 1.00 60.02  ? 1302 HOH A O   1 
HETATM 4992 O  O   . HOH L 8 .   ? -35.743 -50.887 -22.720 1.00 65.59  ? 1303 HOH A O   1 
HETATM 4993 O  O   . HOH L 8 .   ? -37.836 -68.226 -12.434 1.00 60.00  ? 1304 HOH A O   1 
HETATM 4994 O  O   . HOH L 8 .   ? -11.184 -69.853 -25.808 0.40 22.39  ? 1305 HOH A O   1 
HETATM 4995 O  O   . HOH L 8 .   ? -5.880  -68.357 -27.551 1.00 36.62  ? 1306 HOH A O   1 
HETATM 4996 O  O   . HOH L 8 .   ? -34.130 -70.055 -18.562 1.00 47.59  ? 1307 HOH A O   1 
HETATM 4997 O  O   . HOH L 8 .   ? -26.713 -27.809 -41.785 0.50 26.13  ? 1308 HOH A O   1 
HETATM 4998 O  O   . HOH L 8 .   ? -35.589 -59.122 -0.903  1.00 63.80  ? 1309 HOH A O   1 
HETATM 4999 O  O   . HOH L 8 .   ? -9.104  -71.014 -14.732 1.00 44.50  ? 1310 HOH A O   1 
HETATM 5000 O  O   . HOH L 8 .   ? -22.537 -44.570 -33.021 0.50 37.08  ? 1311 HOH A O   1 
HETATM 5001 O  O   . HOH L 8 .   ? 13.509  -30.579 -19.366 1.00 56.64  ? 1312 HOH A O   1 
HETATM 5002 O  O   . HOH L 8 .   ? -30.182 -61.288 -33.772 0.40 35.24  ? 1313 HOH A O   1 
HETATM 5003 O  O   . HOH L 8 .   ? 14.929  -32.101 -31.167 0.50 23.61  ? 1314 HOH A O   1 
HETATM 5004 O  O   . HOH L 8 .   ? -2.532  -40.469 -46.216 1.00 58.97  ? 1315 HOH A O   1 
HETATM 5005 O  O   . HOH L 8 .   ? -26.108 -20.224 -38.748 1.00 69.88  ? 1316 HOH A O   1 
HETATM 5006 O  O   . HOH L 8 .   ? -26.600 -67.818 -28.000 1.00 33.48  ? 1317 HOH A O   1 
HETATM 5007 O  O   . HOH L 8 .   ? -35.400 -67.605 -5.551  1.00 67.93  ? 1318 HOH A O   1 
HETATM 5008 O  O   . HOH L 8 .   ? -23.033 -75.285 -9.370  0.40 36.84  ? 1319 HOH A O   1 
HETATM 5009 O  O   . HOH L 8 .   ? -24.049 -58.167 -46.843 1.00 61.56  ? 1320 HOH A O   1 
HETATM 5010 O  O   . HOH L 8 .   ? -4.425  -62.566 -4.600  1.00 48.64  ? 1321 HOH A O   1 
HETATM 5011 O  O   . HOH L 8 .   ? -32.061 -18.774 -30.904 1.00 49.81  ? 1322 HOH A O   1 
HETATM 5012 O  O   . HOH L 8 .   ? -0.830  -32.433 -25.190 1.00 34.42  ? 1323 HOH A O   1 
HETATM 5013 O  O   . HOH L 8 .   ? -14.851 -56.819 -41.840 1.00 42.89  ? 1324 HOH A O   1 
HETATM 5014 O  O   . HOH L 8 .   ? -4.321  -34.431 -14.283 1.00 62.97  ? 1325 HOH A O   1 
HETATM 5015 O  O   . HOH L 8 .   ? 0.124   -48.395 -36.297 1.00 54.18  ? 1326 HOH A O   1 
HETATM 5016 O  O   . HOH L 8 .   ? -3.807  -56.605 -7.147  1.00 43.14  ? 1327 HOH A O   1 
HETATM 5017 O  O   . HOH L 8 .   ? 0.685   -31.372 -46.740 1.00 52.35  ? 1328 HOH A O   1 
HETATM 5018 O  O   . HOH L 8 .   ? -27.159 -26.804 -35.544 1.00 40.75  ? 1329 HOH A O   1 
HETATM 5019 O  O   . HOH L 8 .   ? 4.253   -48.828 -29.743 1.00 24.39  ? 1330 HOH A O   1 
HETATM 5020 O  O   . HOH L 8 .   ? -23.060 -37.179 -32.437 1.00 58.00  ? 1331 HOH A O   1 
HETATM 5021 O  O   . HOH L 8 .   ? 3.525   -33.712 -14.040 1.00 54.45  ? 1332 HOH A O   1 
HETATM 5022 O  O   . HOH L 8 .   ? -8.345  -27.742 -46.218 0.50 81.36  ? 1333 HOH A O   1 
HETATM 5023 O  O   . HOH L 8 .   ? -7.997  -30.085 -46.145 0.50 50.17  ? 1334 HOH A O   1 
HETATM 5024 O  O   . HOH L 8 .   ? -13.923 -45.912 3.211   1.00 79.87  ? 1335 HOH A O   1 
HETATM 5025 O  O   . HOH L 8 .   ? -34.747 -59.383 -28.936 1.00 54.07  ? 1336 HOH A O   1 
HETATM 5026 O  O   . HOH L 8 .   ? -13.078 -32.815 -20.227 1.00 35.30  ? 1337 HOH A O   1 
HETATM 5027 O  O   . HOH L 8 .   ? -0.159  -46.105 -42.717 1.00 60.25  ? 1338 HOH A O   1 
HETATM 5028 O  O   . HOH L 8 .   ? -2.872  -57.996 -24.514 1.00 29.29  ? 1339 HOH A O   1 
HETATM 5029 O  O   . HOH L 8 .   ? 10.377  -29.033 -33.663 1.00 54.28  ? 1340 HOH A O   1 
HETATM 5030 O  O   . HOH L 8 .   ? -13.509 -11.279 -31.805 1.00 61.25  ? 1341 HOH A O   1 
HETATM 5031 O  O   . HOH L 8 .   ? -22.802 -29.537 -14.091 1.00 67.31  ? 1342 HOH A O   1 
HETATM 5032 O  O   . HOH L 8 .   ? -9.954  -54.824 -41.701 1.00 67.47  ? 1343 HOH A O   1 
HETATM 5033 O  O   . HOH L 8 .   ? 4.755   -68.842 -21.447 1.00 40.23  ? 1344 HOH A O   1 
HETATM 5034 O  O   . HOH L 8 .   ? -19.385 -64.662 -2.769  1.00 52.91  ? 1345 HOH A O   1 
HETATM 5035 O  O   . HOH L 8 .   ? -21.147 -43.470 -41.305 1.00 62.76  ? 1346 HOH A O   1 
HETATM 5036 O  O   . HOH L 8 .   ? -20.119 -31.209 -26.412 1.00 34.77  ? 1347 HOH A O   1 
HETATM 5037 O  O   . HOH L 8 .   ? -5.735  -68.839 -6.940  1.00 43.20  ? 1348 HOH A O   1 
HETATM 5038 O  O   . HOH L 8 .   ? -12.419 -37.852 -22.032 1.00 54.18  ? 1349 HOH A O   1 
HETATM 5039 O  O   . HOH L 8 .   ? 4.361   -62.400 -19.927 1.00 29.10  ? 1350 HOH A O   1 
HETATM 5040 O  O   . HOH L 8 .   ? 0.542   -45.112 -36.673 1.00 47.97  ? 1351 HOH A O   1 
HETATM 5041 O  O   . HOH L 8 .   ? -16.243 -49.204 -16.326 1.00 28.92  ? 1352 HOH A O   1 
HETATM 5042 O  O   . HOH L 8 .   ? -6.106  -43.179 -19.942 1.00 54.97  ? 1353 HOH A O   1 
HETATM 5043 O  O   . HOH L 8 .   ? -17.182 -46.583 -10.802 1.00 59.31  ? 1354 HOH A O   1 
HETATM 5044 O  O   . HOH L 8 .   ? -41.839 -21.835 -17.338 1.00 74.04  ? 1355 HOH A O   1 
HETATM 5045 O  O   . HOH L 8 .   ? -7.266  -29.886 -13.084 1.00 65.27  ? 1356 HOH A O   1 
HETATM 5046 O  O   . HOH L 8 .   ? -40.466 -62.413 -3.031  1.00 57.07  ? 1357 HOH A O   1 
HETATM 5047 O  O   . HOH L 8 .   ? -41.681 -24.155 -17.458 1.00 68.01  ? 1358 HOH A O   1 
HETATM 5048 O  O   . HOH L 8 .   ? -18.193 -46.987 -15.301 1.00 51.63  ? 1359 HOH A O   1 
HETATM 5049 O  O   . HOH L 8 .   ? -11.046 -39.330 -39.780 1.00 54.31  ? 1360 HOH A O   1 
HETATM 5050 O  O   . HOH L 8 .   ? -30.762 -16.546 -31.640 1.00 55.22  ? 1361 HOH A O   1 
HETATM 5051 O  O   . HOH L 8 .   ? 11.367  -37.479 -18.760 1.00 43.97  ? 1362 HOH A O   1 
HETATM 5052 O  O   . HOH L 8 .   ? -10.083 -38.091 -43.231 1.00 63.28  ? 1363 HOH A O   1 
HETATM 5053 O  O   . HOH L 8 .   ? -15.638 -27.202 -46.030 1.00 64.50  ? 1364 HOH A O   1 
HETATM 5054 O  O   . HOH L 8 .   ? 5.561   -44.486 -36.820 0.50 40.36  ? 1365 HOH A O   1 
HETATM 5055 O  O   . HOH L 8 .   ? 3.089   -51.702 -36.023 1.00 60.80  ? 1366 HOH A O   1 
HETATM 5056 O  O   . HOH L 8 .   ? -2.850  -55.621 -28.951 1.00 35.58  ? 1367 HOH A O   1 
HETATM 5057 O  O   . HOH L 8 .   ? -35.100 -62.223 -28.398 1.00 74.20  ? 1368 HOH A O   1 
HETATM 5058 O  O   . HOH L 8 .   ? -3.449  -52.147 -5.072  1.00 67.81  ? 1369 HOH A O   1 
HETATM 5059 O  O   . HOH L 8 .   ? -18.712 -34.480 -43.472 0.50 46.99  ? 1370 HOH A O   1 
HETATM 5060 O  O   . HOH L 8 .   ? -17.580 -28.085 -44.504 1.00 58.71  ? 1371 HOH A O   1 
HETATM 5061 O  O   . HOH L 8 .   ? -15.574 -41.580 -38.498 1.00 47.74  ? 1372 HOH A O   1 
HETATM 5062 O  O   . HOH L 8 .   ? -23.688 -47.406 -33.353 0.50 38.02  ? 1373 HOH A O   1 
HETATM 5063 O  O   . HOH L 8 .   ? -10.756 -68.201 -38.004 1.00 69.40  ? 1374 HOH A O   1 
HETATM 5064 O  O   . HOH L 8 .   ? -24.879 -27.414 -20.057 1.00 68.90  ? 1375 HOH A O   1 
HETATM 5065 O  O   . HOH L 8 .   ? -9.603  -23.468 -3.489  1.00 75.37  ? 1376 HOH A O   1 
HETATM 5066 O  O   . HOH L 8 .   ? -37.005 -64.721 0.001   1.00 51.82  ? 1377 HOH A O   1 
HETATM 5067 O  O   . HOH L 8 .   ? -10.321 -17.486 -40.237 1.00 55.80  ? 1378 HOH A O   1 
HETATM 5068 O  O   . HOH L 8 .   ? 5.098   -51.403 -30.933 1.00 58.25  ? 1379 HOH A O   1 
HETATM 5069 O  O   . HOH L 8 .   ? 0.031   -42.277 -21.567 0.40 34.97  ? 1380 HOH A O   1 
HETATM 5070 O  O   . HOH L 8 .   ? -36.105 -57.182 -4.156  1.00 70.14  ? 1381 HOH A O   1 
HETATM 5071 O  O   . HOH L 8 .   ? -27.005 -73.703 -4.724  1.00 56.28  ? 1382 HOH A O   1 
HETATM 5072 O  O   . HOH L 8 .   ? -19.260 -13.680 -38.272 1.00 66.71  ? 1383 HOH A O   1 
HETATM 5073 O  O   . HOH L 8 .   ? -42.427 -66.529 -10.717 1.00 58.74  ? 1384 HOH A O   1 
HETATM 5074 O  O   . HOH L 8 .   ? -18.782 -39.759 -38.481 1.00 59.50  ? 1385 HOH A O   1 
HETATM 5075 O  O   . HOH L 8 .   ? -14.778 -45.337 -10.124 1.00 68.62  ? 1386 HOH A O   1 
HETATM 5076 O  O   . HOH L 8 .   ? -15.874 -69.216 -5.961  1.00 35.73  ? 1387 HOH A O   1 
HETATM 5077 O  O   . HOH L 8 .   ? -38.302 -62.079 -0.492  1.00 69.06  ? 1388 HOH A O   1 
HETATM 5078 O  O   . HOH L 8 .   ? -34.229 -49.417 -10.189 1.00 48.95  ? 1389 HOH A O   1 
HETATM 5079 O  O   . HOH L 8 .   ? -24.987 -28.604 -22.499 1.00 52.70  ? 1390 HOH A O   1 
HETATM 5080 O  O   . HOH L 8 .   ? -38.088 -52.136 -4.189  1.00 53.13  ? 1391 HOH A O   1 
HETATM 5081 O  O   . HOH L 8 .   ? -7.124  -74.341 -13.263 1.00 69.18  ? 1392 HOH A O   1 
HETATM 5082 O  O   . HOH L 8 .   ? -16.692 -39.130 -39.735 1.00 51.60  ? 1393 HOH A O   1 
HETATM 5083 O  O   . HOH L 8 .   ? 0.000   -58.132 -15.800 0.50 54.87  ? 1394 HOH A O   1 
HETATM 5084 O  O   . HOH L 8 .   ? -41.228 -59.470 -13.784 1.00 46.52  ? 1395 HOH A O   1 
HETATM 5085 O  O   . HOH L 8 .   ? -9.186  -71.224 -25.874 0.40 29.76  ? 1396 HOH A O   1 
HETATM 5086 O  O   . HOH L 8 .   ? -5.169  -66.688 -6.025  1.00 62.64  ? 1397 HOH A O   1 
HETATM 5087 O  O   . HOH L 8 .   ? -35.118 -70.955 -13.722 1.00 69.71  ? 1398 HOH A O   1 
HETATM 5088 O  O   . HOH L 8 .   ? 0.000   -58.132 -28.694 0.50 41.03  ? 1399 HOH A O   1 
HETATM 5089 O  O   . HOH L 8 .   ? -14.729 -76.308 -19.948 0.40 37.51  ? 1400 HOH A O   1 
HETATM 5090 O  O   . HOH L 8 .   ? -1.312  -58.631 -31.965 1.00 68.09  ? 1401 HOH A O   1 
HETATM 5091 O  O   . HOH L 8 .   ? -5.921  -44.739 -17.715 1.00 68.43  ? 1402 HOH A O   1 
HETATM 5092 O  O   . HOH L 8 .   ? 0.496   -62.293 -17.471 1.00 43.05  ? 1403 HOH A O   1 
HETATM 5093 O  O   . HOH L 8 .   ? -0.783  -62.846 -15.342 1.00 59.58  ? 1404 HOH A O   1 
HETATM 5094 O  O   . HOH L 8 .   ? -18.234 -67.898 -6.434  1.00 28.60  ? 1405 HOH A O   1 
HETATM 5095 O  O   . HOH L 8 .   ? -35.535 -47.748 -14.182 1.00 64.28  ? 1406 HOH A O   1 
HETATM 5096 O  O   . HOH L 8 .   ? 16.660  -34.619 -26.319 1.00 60.57  ? 1407 HOH A O   1 
HETATM 5097 O  O   . HOH L 8 .   ? -1.315  -54.669 -1.166  1.00 61.41  ? 1408 HOH A O   1 
HETATM 5098 O  O   . HOH L 8 .   ? -19.831 -68.060 -4.272  1.00 36.42  ? 1409 HOH A O   1 
HETATM 5099 O  O   . HOH L 8 .   ? -2.694  -56.443 -33.998 1.00 56.71  ? 1410 HOH A O   1 
HETATM 5100 O  O   . HOH L 8 .   ? -3.906  -49.127 3.046   1.00 68.06  ? 1411 HOH A O   1 
HETATM 5101 O  O   . HOH L 8 .   ? -8.440  -34.851 -46.649 0.50 51.28  ? 1412 HOH A O   1 
HETATM 5102 O  O   . HOH L 8 .   ? -5.507  -64.256 -6.660  1.00 57.21  ? 1413 HOH A O   1 
HETATM 5103 O  O   . HOH L 8 .   ? -32.432 -66.919 -23.107 1.00 67.96  ? 1414 HOH A O   1 
HETATM 5104 O  O   . HOH L 8 .   ? 10.458  -20.587 -25.557 1.00 64.35  ? 1415 HOH A O   1 
HETATM 5105 O  O   . HOH L 8 .   ? -25.287 -43.616 -33.593 1.00 69.83  ? 1416 HOH A O   1 
HETATM 5106 O  O   . HOH L 8 .   ? -19.222 -46.080 -18.468 1.00 69.96  ? 1417 HOH A O   1 
HETATM 5107 O  O   . HOH L 8 .   ? -28.303 -55.547 -45.046 1.00 60.90  ? 1418 HOH A O   1 
HETATM 5108 O  O   . HOH L 8 .   ? 13.348  -25.185 -25.906 1.00 69.44  ? 1419 HOH A O   1 
HETATM 5109 O  O   . HOH L 8 .   ? -4.036  -61.163 -10.089 1.00 62.84  ? 1420 HOH A O   1 
HETATM 5110 O  O   . HOH L 8 .   ? -2.620  -59.415 -7.817  1.00 67.44  ? 1421 HOH A O   1 
HETATM 5111 O  O   . HOH L 8 .   ? -42.865 -61.022 -1.823  1.00 63.39  ? 1422 HOH A O   1 
HETATM 5112 O  O   . HOH L 8 .   ? -4.062  -62.764 -8.311  1.00 56.61  ? 1423 HOH A O   1 
# 
