data_7I2K
# 
_entry.id   7I2K 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   7I2K         pdb_00007i2k 10.2210/pdb7i2k/pdb 
WWPDB D_1001408235 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-02 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.entry_id                        7I2K 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.recvd_initial_deposition_date   2025-03-06 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.SG_entry                        ? 
_pdbx_database_status.pdb_format_compatible           N 
_pdbx_database_status.methods_development_category    ? 
# 
_pdbx_contact_author.id                 1 
_pdbx_contact_author.email              fr193@cabm.rutgers.edu 
_pdbx_contact_author.name_first         'Francesc Xavier' 
_pdbx_contact_author.name_last          Ruiz 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0457-0030 
_pdbx_contact_author.name_mi            ? 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Aschenbrenner, J.C.' 1  ? 
'Saini, M.'           2  ? 
'Chopra, A.'          3  ? 
'Marples, P.G.'       4  ? 
'Balcomb, B.H.'       5  ? 
'Lithgo, R.M.'        6  ? 
'Fearon, D.'          7  ? 
'von Delft, F.'       8  ? 
'Ruiz, F.X.'          9  ? 
'Arnold, E.'          10 ? 
# 
_citation.id                        primary 
_citation.title                     
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_volume            ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.year                      ? 
_citation.journal_id_ASTM           ? 
_citation.country                   ? 
_citation.journal_id_ISSN           ? 
_citation.journal_id_CSD            0353 
_citation.book_publisher            ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_DOI      ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.identifier_ORCID 
_citation_author.ordinal 
primary 'Aschenbrenner, J.C.' ? 1  
primary 'Saini, M.'           ? 2  
primary 'Chopra, A.'          ? 3  
primary 'Marples, P.G.'       ? 4  
primary 'Balcomb, B.H.'       ? 5  
primary 'Lithgo, R.M.'        ? 6  
primary 'Fearon, D.'          ? 7  
primary 'von Delft, F.'       ? 8  
primary 'Ruiz, F.X.'          ? 9  
primary 'Arnold, E.'          ? 10 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'NS5 RNA-dependent RNA polymerase'             73890.008 1   ? ? ? ? 
2 non-polymer syn 'ZINC ION'                                     65.409    2   ? ? ? ? 
3 non-polymer syn '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'         195.237   1   ? ? ? ? 
4 non-polymer syn 'DIMETHYL SULFOXIDE'                           78.133    2   ? ? ? ? 
5 non-polymer syn 'PHOSPHATE ION'                                94.971    2   ? ? ? ? 
6 non-polymer syn 'DI(HYDROXYETHYL)ETHER'                        106.120   1   ? ? ? ? 
7 non-polymer syn 'CHLORIDE ION'                                 35.453    2   ? ? ? ? 
8 non-polymer syn '1-(3-methoxyazetidine-1-sulfonyl)pyrrolidine' 220.289   1   ? ? ? ? 
9 water       nat water                                          18.015    335 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION'                                     ZN    
3 '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'         MES   
4 'DIMETHYL SULFOXIDE'                           DMS   
5 'PHOSPHATE ION'                                PO4   
6 'DI(HYDROXYETHYL)ETHER'                        PEG   
7 'CHLORIDE ION'                                 CL    
8 '1-(3-methoxyazetidine-1-sulfonyl)pyrrolidine' A1BFU 
9 water                                          HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PRO n 
1 3   GLY n 
1 4   ILE n 
1 5   GLU n 
1 6   SER n 
1 7   GLU n 
1 8   THR n 
1 9   PRO n 
1 10  ASN n 
1 11  LEU n 
1 12  ASP n 
1 13  ILE n 
1 14  ILE n 
1 15  GLY n 
1 16  LYS n 
1 17  ARG n 
1 18  ILE n 
1 19  GLU n 
1 20  LYS n 
1 21  ILE n 
1 22  LYS n 
1 23  GLN n 
1 24  GLU n 
1 25  HIS n 
1 26  GLU n 
1 27  THR n 
1 28  SER n 
1 29  TRP n 
1 30  HIS n 
1 31  TYR n 
1 32  ASP n 
1 33  GLN n 
1 34  ASP n 
1 35  HIS n 
1 36  PRO n 
1 37  TYR n 
1 38  LYS n 
1 39  THR n 
1 40  TRP n 
1 41  ALA n 
1 42  TYR n 
1 43  HIS n 
1 44  GLY n 
1 45  SER n 
1 46  TYR n 
1 47  GLU n 
1 48  THR n 
1 49  LYS n 
1 50  GLN n 
1 51  THR n 
1 52  GLY n 
1 53  SER n 
1 54  ALA n 
1 55  SER n 
1 56  SER n 
1 57  MET n 
1 58  VAL n 
1 59  ASN n 
1 60  GLY n 
1 61  VAL n 
1 62  VAL n 
1 63  ARG n 
1 64  LEU n 
1 65  LEU n 
1 66  THR n 
1 67  LYS n 
1 68  PRO n 
1 69  TRP n 
1 70  ASP n 
1 71  ILE n 
1 72  ILE n 
1 73  PRO n 
1 74  MET n 
1 75  VAL n 
1 76  THR n 
1 77  GLN n 
1 78  MET n 
1 79  ALA n 
1 80  MET n 
1 81  THR n 
1 82  ASP n 
1 83  THR n 
1 84  THR n 
1 85  PRO n 
1 86  PHE n 
1 87  GLY n 
1 88  GLN n 
1 89  GLN n 
1 90  ARG n 
1 91  VAL n 
1 92  PHE n 
1 93  LYS n 
1 94  GLU n 
1 95  LYS n 
1 96  VAL n 
1 97  ASP n 
1 98  THR n 
1 99  ARG n 
1 100 THR n 
1 101 GLN n 
1 102 GLU n 
1 103 PRO n 
1 104 LYS n 
1 105 GLU n 
1 106 GLY n 
1 107 THR n 
1 108 LYS n 
1 109 LYS n 
1 110 LEU n 
1 111 MET n 
1 112 LYS n 
1 113 ILE n 
1 114 THR n 
1 115 ALA n 
1 116 GLU n 
1 117 TRP n 
1 118 LEU n 
1 119 TRP n 
1 120 LYS n 
1 121 GLU n 
1 122 LEU n 
1 123 GLY n 
1 124 LYS n 
1 125 LYS n 
1 126 LYS n 
1 127 THR n 
1 128 PRO n 
1 129 ARG n 
1 130 MET n 
1 131 CYS n 
1 132 THR n 
1 133 ARG n 
1 134 GLU n 
1 135 GLU n 
1 136 PHE n 
1 137 THR n 
1 138 ARG n 
1 139 LYS n 
1 140 VAL n 
1 141 ARG n 
1 142 SER n 
1 143 ASN n 
1 144 ALA n 
1 145 ALA n 
1 146 LEU n 
1 147 GLY n 
1 148 ALA n 
1 149 ILE n 
1 150 PHE n 
1 151 THR n 
1 152 ASP n 
1 153 GLU n 
1 154 ASN n 
1 155 LYS n 
1 156 TRP n 
1 157 LYS n 
1 158 SER n 
1 159 ALA n 
1 160 ARG n 
1 161 GLU n 
1 162 ALA n 
1 163 VAL n 
1 164 GLU n 
1 165 ASP n 
1 166 SER n 
1 167 GLY n 
1 168 PHE n 
1 169 TRP n 
1 170 GLU n 
1 171 LEU n 
1 172 VAL n 
1 173 ASP n 
1 174 LYS n 
1 175 GLU n 
1 176 ARG n 
1 177 ASN n 
1 178 LEU n 
1 179 HIS n 
1 180 LEU n 
1 181 GLU n 
1 182 GLY n 
1 183 LYS n 
1 184 CYS n 
1 185 GLU n 
1 186 THR n 
1 187 CYS n 
1 188 VAL n 
1 189 TYR n 
1 190 ASN n 
1 191 MET n 
1 192 MET n 
1 193 GLY n 
1 194 LYS n 
1 195 ARG n 
1 196 GLU n 
1 197 LYS n 
1 198 LYS n 
1 199 LEU n 
1 200 GLY n 
1 201 GLU n 
1 202 PHE n 
1 203 GLY n 
1 204 LYS n 
1 205 ALA n 
1 206 LYS n 
1 207 GLY n 
1 208 SER n 
1 209 ARG n 
1 210 ALA n 
1 211 ILE n 
1 212 TRP n 
1 213 TYR n 
1 214 MET n 
1 215 TRP n 
1 216 LEU n 
1 217 GLY n 
1 218 ALA n 
1 219 ARG n 
1 220 PHE n 
1 221 LEU n 
1 222 GLU n 
1 223 PHE n 
1 224 GLU n 
1 225 ALA n 
1 226 LEU n 
1 227 GLY n 
1 228 PHE n 
1 229 LEU n 
1 230 ASN n 
1 231 GLU n 
1 232 ASP n 
1 233 HIS n 
1 234 TRP n 
1 235 PHE n 
1 236 SER n 
1 237 ARG n 
1 238 GLU n 
1 239 ASN n 
1 240 SER n 
1 241 LEU n 
1 242 SER n 
1 243 GLY n 
1 244 VAL n 
1 245 GLU n 
1 246 GLY n 
1 247 GLU n 
1 248 GLY n 
1 249 LEU n 
1 250 HIS n 
1 251 LYS n 
1 252 LEU n 
1 253 GLY n 
1 254 TYR n 
1 255 ILE n 
1 256 LEU n 
1 257 ARG n 
1 258 ASP n 
1 259 VAL n 
1 260 SER n 
1 261 LYS n 
1 262 LYS n 
1 263 GLU n 
1 264 GLY n 
1 265 GLY n 
1 266 ALA n 
1 267 MET n 
1 268 TYR n 
1 269 ALA n 
1 270 ASP n 
1 271 ASP n 
1 272 THR n 
1 273 ALA n 
1 274 GLY n 
1 275 TRP n 
1 276 ASP n 
1 277 THR n 
1 278 ARG n 
1 279 ILE n 
1 280 THR n 
1 281 LEU n 
1 282 GLU n 
1 283 ASP n 
1 284 LEU n 
1 285 LYS n 
1 286 ASN n 
1 287 GLU n 
1 288 GLU n 
1 289 MET n 
1 290 VAL n 
1 291 THR n 
1 292 ASN n 
1 293 HIS n 
1 294 MET n 
1 295 GLU n 
1 296 GLY n 
1 297 GLU n 
1 298 HIS n 
1 299 LYS n 
1 300 LYS n 
1 301 LEU n 
1 302 ALA n 
1 303 GLU n 
1 304 ALA n 
1 305 ILE n 
1 306 PHE n 
1 307 LYS n 
1 308 LEU n 
1 309 THR n 
1 310 TYR n 
1 311 GLN n 
1 312 ASN n 
1 313 LYS n 
1 314 VAL n 
1 315 VAL n 
1 316 ARG n 
1 317 VAL n 
1 318 GLN n 
1 319 ARG n 
1 320 PRO n 
1 321 THR n 
1 322 PRO n 
1 323 ARG n 
1 324 GLY n 
1 325 THR n 
1 326 VAL n 
1 327 MET n 
1 328 ASP n 
1 329 ILE n 
1 330 ILE n 
1 331 SER n 
1 332 ARG n 
1 333 ARG n 
1 334 ASP n 
1 335 GLN n 
1 336 ARG n 
1 337 GLY n 
1 338 SER n 
1 339 GLY n 
1 340 GLN n 
1 341 VAL n 
1 342 VAL n 
1 343 THR n 
1 344 TYR n 
1 345 GLY n 
1 346 LEU n 
1 347 ASN n 
1 348 THR n 
1 349 PHE n 
1 350 THR n 
1 351 ASN n 
1 352 MET n 
1 353 GLU n 
1 354 ALA n 
1 355 GLN n 
1 356 LEU n 
1 357 ILE n 
1 358 ARG n 
1 359 GLN n 
1 360 MET n 
1 361 GLU n 
1 362 GLY n 
1 363 GLU n 
1 364 GLY n 
1 365 VAL n 
1 366 PHE n 
1 367 LYS n 
1 368 SER n 
1 369 ILE n 
1 370 GLN n 
1 371 HIS n 
1 372 LEU n 
1 373 THR n 
1 374 VAL n 
1 375 THR n 
1 376 GLU n 
1 377 GLU n 
1 378 ILE n 
1 379 ALA n 
1 380 VAL n 
1 381 LYS n 
1 382 ASN n 
1 383 TRP n 
1 384 LEU n 
1 385 VAL n 
1 386 ARG n 
1 387 VAL n 
1 388 GLY n 
1 389 ARG n 
1 390 GLU n 
1 391 ARG n 
1 392 LEU n 
1 393 SER n 
1 394 ARG n 
1 395 MET n 
1 396 ALA n 
1 397 ILE n 
1 398 SER n 
1 399 GLY n 
1 400 ASP n 
1 401 ASP n 
1 402 CYS n 
1 403 VAL n 
1 404 VAL n 
1 405 LYS n 
1 406 PRO n 
1 407 LEU n 
1 408 ASP n 
1 409 ASP n 
1 410 ARG n 
1 411 PHE n 
1 412 ALA n 
1 413 SER n 
1 414 ALA n 
1 415 LEU n 
1 416 THR n 
1 417 ALA n 
1 418 LEU n 
1 419 ASN n 
1 420 ASP n 
1 421 MET n 
1 422 GLY n 
1 423 LYS n 
1 424 VAL n 
1 425 ARG n 
1 426 LYS n 
1 427 ASP n 
1 428 ILE n 
1 429 GLN n 
1 430 GLN n 
1 431 TRP n 
1 432 GLU n 
1 433 PRO n 
1 434 SER n 
1 435 ARG n 
1 436 GLY n 
1 437 TRP n 
1 438 ASN n 
1 439 ASP n 
1 440 TRP n 
1 441 THR n 
1 442 GLN n 
1 443 VAL n 
1 444 PRO n 
1 445 PHE n 
1 446 CYS n 
1 447 SER n 
1 448 HIS n 
1 449 HIS n 
1 450 PHE n 
1 451 HIS n 
1 452 GLU n 
1 453 LEU n 
1 454 ILE n 
1 455 MET n 
1 456 LYS n 
1 457 ASP n 
1 458 GLY n 
1 459 ARG n 
1 460 VAL n 
1 461 LEU n 
1 462 VAL n 
1 463 VAL n 
1 464 PRO n 
1 465 CYS n 
1 466 ARG n 
1 467 ASN n 
1 468 GLN n 
1 469 ASP n 
1 470 GLU n 
1 471 LEU n 
1 472 ILE n 
1 473 GLY n 
1 474 ARG n 
1 475 ALA n 
1 476 ARG n 
1 477 ILE n 
1 478 SER n 
1 479 GLN n 
1 480 GLY n 
1 481 ALA n 
1 482 GLY n 
1 483 TRP n 
1 484 SER n 
1 485 LEU n 
1 486 ARG n 
1 487 GLU n 
1 488 THR n 
1 489 ALA n 
1 490 CYS n 
1 491 LEU n 
1 492 GLY n 
1 493 LYS n 
1 494 SER n 
1 495 TYR n 
1 496 ALA n 
1 497 GLN n 
1 498 MET n 
1 499 TRP n 
1 500 SER n 
1 501 LEU n 
1 502 MET n 
1 503 TYR n 
1 504 PHE n 
1 505 HIS n 
1 506 ARG n 
1 507 ARG n 
1 508 ASP n 
1 509 LEU n 
1 510 ARG n 
1 511 LEU n 
1 512 ALA n 
1 513 ALA n 
1 514 ASN n 
1 515 ALA n 
1 516 ILE n 
1 517 CYS n 
1 518 SER n 
1 519 ALA n 
1 520 VAL n 
1 521 PRO n 
1 522 SER n 
1 523 HIS n 
1 524 TRP n 
1 525 VAL n 
1 526 PRO n 
1 527 THR n 
1 528 SER n 
1 529 ARG n 
1 530 THR n 
1 531 THR n 
1 532 TRP n 
1 533 SER n 
1 534 ILE n 
1 535 HIS n 
1 536 ALA n 
1 537 THR n 
1 538 HIS n 
1 539 GLU n 
1 540 TRP n 
1 541 MET n 
1 542 THR n 
1 543 THR n 
1 544 GLU n 
1 545 ASP n 
1 546 MET n 
1 547 LEU n 
1 548 THR n 
1 549 VAL n 
1 550 TRP n 
1 551 ASN n 
1 552 ARG n 
1 553 VAL n 
1 554 TRP n 
1 555 ILE n 
1 556 GLN n 
1 557 GLU n 
1 558 ASN n 
1 559 PRO n 
1 560 TRP n 
1 561 MET n 
1 562 GLU n 
1 563 ASP n 
1 564 LYS n 
1 565 THR n 
1 566 PRO n 
1 567 VAL n 
1 568 GLU n 
1 569 SER n 
1 570 TRP n 
1 571 GLU n 
1 572 GLU n 
1 573 ILE n 
1 574 PRO n 
1 575 TYR n 
1 576 LEU n 
1 577 GLY n 
1 578 LYS n 
1 579 ARG n 
1 580 GLU n 
1 581 ASP n 
1 582 GLN n 
1 583 TRP n 
1 584 CYS n 
1 585 GLY n 
1 586 SER n 
1 587 LEU n 
1 588 ILE n 
1 589 GLY n 
1 590 LEU n 
1 591 THR n 
1 592 SER n 
1 593 ARG n 
1 594 ALA n 
1 595 THR n 
1 596 TRP n 
1 597 ALA n 
1 598 LYS n 
1 599 ASN n 
1 600 ILE n 
1 601 GLN n 
1 602 THR n 
1 603 ALA n 
1 604 ILE n 
1 605 ASN n 
1 606 GLN n 
1 607 VAL n 
1 608 ARG n 
1 609 SER n 
1 610 LEU n 
1 611 ILE n 
1 612 GLY n 
1 613 ASN n 
1 614 GLU n 
1 615 GLU n 
1 616 TYR n 
1 617 THR n 
1 618 ASP n 
1 619 TYR n 
1 620 MET n 
1 621 PRO n 
1 622 SER n 
1 623 MET n 
1 624 LYS n 
1 625 ARG n 
1 626 PHE n 
1 627 ARG n 
1 628 ARG n 
1 629 GLU n 
1 630 GLU n 
1 631 GLU n 
1 632 GLU n 
1 633 ALA n 
1 634 GLY n 
1 635 VAL n 
1 636 LEU n 
1 637 TRP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   637 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'dengue virus type 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     11060 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1BFU non-polymer         . '1-(3-methoxyazetidine-1-sulfonyl)pyrrolidine' ? 'C8 H16 N2 O3 S' 220.289 
ALA   'L-peptide linking' y ALANINE                                        ? 'C3 H7 N O2'     89.093  
ARG   'L-peptide linking' y ARGININE                                       ? 'C6 H15 N4 O2 1' 175.209 
ASN   'L-peptide linking' y ASPARAGINE                                     ? 'C4 H8 N2 O3'    132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID'                                ? 'C4 H7 N O4'     133.103 
CL    non-polymer         . 'CHLORIDE ION'                                 ? 'Cl -1'          35.453  
CYS   'L-peptide linking' y CYSTEINE                                       ? 'C3 H7 N O2 S'   121.158 
DMS   non-polymer         . 'DIMETHYL SULFOXIDE'                           ? 'C2 H6 O S'      78.133  
GLN   'L-peptide linking' y GLUTAMINE                                      ? 'C5 H10 N2 O3'   146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID'                                ? 'C5 H9 N O4'     147.129 
GLY   'peptide linking'   y GLYCINE                                        ? 'C2 H5 N O2'     75.067  
HIS   'L-peptide linking' y HISTIDINE                                      ? 'C6 H10 N3 O2 1' 156.162 
HOH   non-polymer         . WATER                                          ? 'H2 O'           18.015  
ILE   'L-peptide linking' y ISOLEUCINE                                     ? 'C6 H13 N O2'    131.173 
LEU   'L-peptide linking' y LEUCINE                                        ? 'C6 H13 N O2'    131.173 
LYS   'L-peptide linking' y LYSINE                                         ? 'C6 H15 N2 O2 1' 147.195 
MES   non-polymer         . '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'         ? 'C6 H13 N O4 S'  195.237 
MET   'L-peptide linking' y METHIONINE                                     ? 'C5 H11 N O2 S'  149.211 
PEG   non-polymer         . 'DI(HYDROXYETHYL)ETHER'                        ? 'C4 H10 O3'      106.120 
PHE   'L-peptide linking' y PHENYLALANINE                                  ? 'C9 H11 N O2'    165.189 
PO4   non-polymer         . 'PHOSPHATE ION'                                ? 'O4 P -3'        94.971  
PRO   'L-peptide linking' y PROLINE                                        ? 'C5 H9 N O2'     115.130 
SER   'L-peptide linking' y SERINE                                         ? 'C3 H7 N O3'     105.093 
THR   'L-peptide linking' y THREONINE                                      ? 'C4 H9 N O3'     119.119 
TRP   'L-peptide linking' y TRYPTOPHAN                                     ? 'C11 H12 N2 O2'  204.225 
TYR   'L-peptide linking' y TYROSINE                                       ? 'C9 H11 N O3'    181.189 
VAL   'L-peptide linking' y VALINE                                         ? 'C5 H11 N O2'    117.146 
ZN    non-polymer         . 'ZINC ION'                                     ? 'Zn 2'           65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   264 ?   ?   ?   A . n 
A 1 2   PRO 2   265 ?   ?   ?   A . n 
A 1 3   GLY 3   266 ?   ?   ?   A . n 
A 1 4   ILE 4   267 ?   ?   ?   A . n 
A 1 5   GLU 5   268 ?   ?   ?   A . n 
A 1 6   SER 6   269 ?   ?   ?   A . n 
A 1 7   GLU 7   270 ?   ?   ?   A . n 
A 1 8   THR 8   271 ?   ?   ?   A . n 
A 1 9   PRO 9   272 ?   ?   ?   A . n 
A 1 10  ASN 10  273 273 ASN ASN A . n 
A 1 11  LEU 11  274 274 LEU LEU A . n 
A 1 12  ASP 12  275 275 ASP ASP A . n 
A 1 13  ILE 13  276 276 ILE ILE A . n 
A 1 14  ILE 14  277 277 ILE ILE A . n 
A 1 15  GLY 15  278 278 GLY GLY A . n 
A 1 16  LYS 16  279 279 LYS LYS A . n 
A 1 17  ARG 17  280 280 ARG ARG A . n 
A 1 18  ILE 18  281 281 ILE ILE A . n 
A 1 19  GLU 19  282 282 GLU GLU A . n 
A 1 20  LYS 20  283 283 LYS LYS A . n 
A 1 21  ILE 21  284 284 ILE ILE A . n 
A 1 22  LYS 22  285 285 LYS LYS A . n 
A 1 23  GLN 23  286 286 GLN GLN A . n 
A 1 24  GLU 24  287 287 GLU GLU A . n 
A 1 25  HIS 25  288 288 HIS HIS A . n 
A 1 26  GLU 26  289 289 GLU GLU A . n 
A 1 27  THR 27  290 290 THR THR A . n 
A 1 28  SER 28  291 291 SER SER A . n 
A 1 29  TRP 29  292 292 TRP TRP A . n 
A 1 30  HIS 30  293 293 HIS HIS A . n 
A 1 31  TYR 31  294 294 TYR TYR A . n 
A 1 32  ASP 32  295 295 ASP ASP A . n 
A 1 33  GLN 33  296 296 GLN GLN A . n 
A 1 34  ASP 34  297 297 ASP ASP A . n 
A 1 35  HIS 35  298 298 HIS HIS A . n 
A 1 36  PRO 36  299 299 PRO PRO A . n 
A 1 37  TYR 37  300 300 TYR TYR A . n 
A 1 38  LYS 38  301 301 LYS LYS A . n 
A 1 39  THR 39  302 302 THR THR A . n 
A 1 40  TRP 40  303 303 TRP TRP A . n 
A 1 41  ALA 41  304 304 ALA ALA A . n 
A 1 42  TYR 42  305 305 TYR TYR A . n 
A 1 43  HIS 43  306 306 HIS HIS A . n 
A 1 44  GLY 44  307 307 GLY GLY A . n 
A 1 45  SER 45  308 308 SER SER A . n 
A 1 46  TYR 46  309 309 TYR TYR A . n 
A 1 47  GLU 47  310 310 GLU GLU A . n 
A 1 48  THR 48  311 311 THR THR A . n 
A 1 49  LYS 49  312 312 LYS LYS A . n 
A 1 50  GLN 50  313 ?   ?   ?   A . n 
A 1 51  THR 51  314 ?   ?   ?   A . n 
A 1 52  GLY 52  315 ?   ?   ?   A . n 
A 1 53  SER 53  316 ?   ?   ?   A . n 
A 1 54  ALA 54  317 ?   ?   ?   A . n 
A 1 55  SER 55  318 ?   ?   ?   A . n 
A 1 56  SER 56  319 319 SER SER A . n 
A 1 57  MET 57  320 320 MET MET A . n 
A 1 58  VAL 58  321 321 VAL VAL A . n 
A 1 59  ASN 59  322 322 ASN ASN A . n 
A 1 60  GLY 60  323 323 GLY GLY A . n 
A 1 61  VAL 61  324 324 VAL VAL A . n 
A 1 62  VAL 62  325 325 VAL VAL A . n 
A 1 63  ARG 63  326 326 ARG ARG A . n 
A 1 64  LEU 64  327 327 LEU LEU A . n 
A 1 65  LEU 65  328 328 LEU LEU A . n 
A 1 66  THR 66  329 329 THR THR A . n 
A 1 67  LYS 67  330 330 LYS LYS A . n 
A 1 68  PRO 68  331 331 PRO PRO A . n 
A 1 69  TRP 69  332 332 TRP TRP A . n 
A 1 70  ASP 70  333 333 ASP ASP A . n 
A 1 71  ILE 71  334 334 ILE ILE A . n 
A 1 72  ILE 72  335 335 ILE ILE A . n 
A 1 73  PRO 73  336 336 PRO PRO A . n 
A 1 74  MET 74  337 337 MET MET A . n 
A 1 75  VAL 75  338 338 VAL VAL A . n 
A 1 76  THR 76  339 339 THR THR A . n 
A 1 77  GLN 77  340 340 GLN GLN A . n 
A 1 78  MET 78  341 341 MET MET A . n 
A 1 79  ALA 79  342 342 ALA ALA A . n 
A 1 80  MET 80  343 343 MET MET A . n 
A 1 81  THR 81  344 344 THR GLY A . n 
A 1 82  ASP 82  345 ?   ?   ?   A . n 
A 1 83  THR 83  346 ?   ?   ?   A . n 
A 1 84  THR 84  347 ?   ?   ?   A . n 
A 1 85  PRO 85  348 ?   ?   ?   A . n 
A 1 86  PHE 86  349 ?   ?   ?   A . n 
A 1 87  GLY 87  350 ?   ?   ?   A . n 
A 1 88  GLN 88  351 ?   ?   ?   A . n 
A 1 89  GLN 89  352 ?   ?   ?   A . n 
A 1 90  ARG 90  353 ?   ?   ?   A . n 
A 1 91  VAL 91  354 ?   ?   ?   A . n 
A 1 92  PHE 92  355 ?   ?   ?   A . n 
A 1 93  LYS 93  356 356 LYS LYS A . n 
A 1 94  GLU 94  357 357 GLU GLU A . n 
A 1 95  LYS 95  358 358 LYS LYS A . n 
A 1 96  VAL 96  359 359 VAL VAL A . n 
A 1 97  ASP 97  360 360 ASP ASP A . n 
A 1 98  THR 98  361 361 THR THR A . n 
A 1 99  ARG 99  362 362 ARG ARG A . n 
A 1 100 THR 100 363 363 THR THR A . n 
A 1 101 GLN 101 364 364 GLN GLN A . n 
A 1 102 GLU 102 365 365 GLU GLU A . n 
A 1 103 PRO 103 366 366 PRO PRO A . n 
A 1 104 LYS 104 367 367 LYS LYS A . n 
A 1 105 GLU 105 368 368 GLU GLU A . n 
A 1 106 GLY 106 369 369 GLY GLY A . n 
A 1 107 THR 107 370 370 THR THR A . n 
A 1 108 LYS 108 371 371 LYS LYS A . n 
A 1 109 LYS 109 372 372 LYS LYS A . n 
A 1 110 LEU 110 373 373 LEU LEU A . n 
A 1 111 MET 111 374 374 MET MET A . n 
A 1 112 LYS 112 375 375 LYS LYS A . n 
A 1 113 ILE 113 376 376 ILE ILE A . n 
A 1 114 THR 114 377 377 THR THR A . n 
A 1 115 ALA 115 378 378 ALA ALA A . n 
A 1 116 GLU 116 379 379 GLU GLU A . n 
A 1 117 TRP 117 380 380 TRP TRP A . n 
A 1 118 LEU 118 381 381 LEU LEU A . n 
A 1 119 TRP 119 382 382 TRP TRP A . n 
A 1 120 LYS 120 383 383 LYS LYS A . n 
A 1 121 GLU 121 384 384 GLU GLU A . n 
A 1 122 LEU 122 385 385 LEU LEU A . n 
A 1 123 GLY 123 386 386 GLY GLY A . n 
A 1 124 LYS 124 387 387 LYS LYS A . n 
A 1 125 LYS 125 388 388 LYS LYS A . n 
A 1 126 LYS 126 389 389 LYS LYS A . n 
A 1 127 THR 127 390 390 THR THR A . n 
A 1 128 PRO 128 391 391 PRO PRO A . n 
A 1 129 ARG 129 392 392 ARG ARG A . n 
A 1 130 MET 130 393 393 MET MET A . n 
A 1 131 CYS 131 394 394 CYS CYS A . n 
A 1 132 THR 132 395 395 THR THR A . n 
A 1 133 ARG 133 396 396 ARG ARG A . n 
A 1 134 GLU 134 397 397 GLU GLU A . n 
A 1 135 GLU 135 398 398 GLU GLU A . n 
A 1 136 PHE 136 399 399 PHE PHE A . n 
A 1 137 THR 137 400 400 THR THR A . n 
A 1 138 ARG 138 401 401 ARG ARG A . n 
A 1 139 LYS 139 402 402 LYS LYS A . n 
A 1 140 VAL 140 403 403 VAL VAL A . n 
A 1 141 ARG 141 404 404 ARG ARG A . n 
A 1 142 SER 142 405 405 SER SER A . n 
A 1 143 ASN 143 406 406 ASN ASN A . n 
A 1 144 ALA 144 407 407 ALA ALA A . n 
A 1 145 ALA 145 408 408 ALA ALA A . n 
A 1 146 LEU 146 409 409 LEU LEU A . n 
A 1 147 GLY 147 410 410 GLY GLY A . n 
A 1 148 ALA 148 411 411 ALA ALA A . n 
A 1 149 ILE 149 412 412 ILE ILE A . n 
A 1 150 PHE 150 413 ?   ?   ?   A . n 
A 1 151 THR 151 414 ?   ?   ?   A . n 
A 1 152 ASP 152 415 ?   ?   ?   A . n 
A 1 153 GLU 153 416 ?   ?   ?   A . n 
A 1 154 ASN 154 417 ?   ?   ?   A . n 
A 1 155 LYS 155 418 418 LYS LYS A . n 
A 1 156 TRP 156 419 419 TRP TRP A . n 
A 1 157 LYS 157 420 420 LYS LYS A . n 
A 1 158 SER 158 421 421 SER SER A . n 
A 1 159 ALA 159 422 422 ALA ALA A . n 
A 1 160 ARG 160 423 423 ARG ARG A . n 
A 1 161 GLU 161 424 424 GLU GLU A . n 
A 1 162 ALA 162 425 425 ALA ALA A . n 
A 1 163 VAL 163 426 426 VAL VAL A . n 
A 1 164 GLU 164 427 427 GLU GLU A . n 
A 1 165 ASP 165 428 428 ASP ASP A . n 
A 1 166 SER 166 429 429 SER SER A . n 
A 1 167 GLY 167 430 430 GLY GLY A . n 
A 1 168 PHE 168 431 431 PHE PHE A . n 
A 1 169 TRP 169 432 432 TRP TRP A . n 
A 1 170 GLU 170 433 433 GLU GLU A . n 
A 1 171 LEU 171 434 434 LEU LEU A . n 
A 1 172 VAL 172 435 435 VAL VAL A . n 
A 1 173 ASP 173 436 436 ASP ASP A . n 
A 1 174 LYS 174 437 437 LYS LYS A . n 
A 1 175 GLU 175 438 438 GLU GLU A . n 
A 1 176 ARG 176 439 439 ARG ARG A . n 
A 1 177 ASN 177 440 440 ASN ASN A . n 
A 1 178 LEU 178 441 441 LEU LEU A . n 
A 1 179 HIS 179 442 442 HIS HIS A . n 
A 1 180 LEU 180 443 443 LEU LEU A . n 
A 1 181 GLU 181 444 444 GLU GLU A . n 
A 1 182 GLY 182 445 445 GLY GLY A . n 
A 1 183 LYS 183 446 446 LYS LYS A . n 
A 1 184 CYS 184 447 447 CYS CYS A . n 
A 1 185 GLU 185 448 448 GLU GLU A . n 
A 1 186 THR 186 449 449 THR THR A . n 
A 1 187 CYS 187 450 450 CYS CYS A . n 
A 1 188 VAL 188 451 451 VAL VAL A . n 
A 1 189 TYR 189 452 452 TYR TYR A . n 
A 1 190 ASN 190 453 453 ASN ASN A . n 
A 1 191 MET 191 454 454 MET MET A . n 
A 1 192 MET 192 455 455 MET MET A . n 
A 1 193 GLY 193 456 ?   ?   ?   A . n 
A 1 194 LYS 194 457 ?   ?   ?   A . n 
A 1 195 ARG 195 458 ?   ?   ?   A . n 
A 1 196 GLU 196 459 ?   ?   ?   A . n 
A 1 197 LYS 197 460 ?   ?   ?   A . n 
A 1 198 LYS 198 461 ?   ?   ?   A . n 
A 1 199 LEU 199 462 ?   ?   ?   A . n 
A 1 200 GLY 200 463 ?   ?   ?   A . n 
A 1 201 GLU 201 464 ?   ?   ?   A . n 
A 1 202 PHE 202 465 ?   ?   ?   A . n 
A 1 203 GLY 203 466 ?   ?   ?   A . n 
A 1 204 LYS 204 467 ?   ?   ?   A . n 
A 1 205 ALA 205 468 ?   ?   ?   A . n 
A 1 206 LYS 206 469 ?   ?   ?   A . n 
A 1 207 GLY 207 470 ?   ?   ?   A . n 
A 1 208 SER 208 471 ?   ?   ?   A . n 
A 1 209 ARG 209 472 ?   ?   ?   A . n 
A 1 210 ALA 210 473 473 ALA ALA A . n 
A 1 211 ILE 211 474 474 ILE ILE A . n 
A 1 212 TRP 212 475 475 TRP TRP A . n 
A 1 213 TYR 213 476 476 TYR TYR A . n 
A 1 214 MET 214 477 477 MET MET A . n 
A 1 215 TRP 215 478 478 TRP TRP A . n 
A 1 216 LEU 216 479 479 LEU LEU A . n 
A 1 217 GLY 217 480 480 GLY GLY A . n 
A 1 218 ALA 218 481 481 ALA ALA A . n 
A 1 219 ARG 219 482 482 ARG ARG A . n 
A 1 220 PHE 220 483 483 PHE PHE A . n 
A 1 221 LEU 221 484 484 LEU LEU A . n 
A 1 222 GLU 222 485 485 GLU GLU A . n 
A 1 223 PHE 223 486 486 PHE PHE A . n 
A 1 224 GLU 224 487 487 GLU GLU A . n 
A 1 225 ALA 225 488 488 ALA ALA A . n 
A 1 226 LEU 226 489 489 LEU LEU A . n 
A 1 227 GLY 227 490 490 GLY GLY A . n 
A 1 228 PHE 228 491 491 PHE PHE A . n 
A 1 229 LEU 229 492 492 LEU LEU A . n 
A 1 230 ASN 230 493 493 ASN ASN A . n 
A 1 231 GLU 231 494 494 GLU GLU A . n 
A 1 232 ASP 232 495 495 ASP ASP A . n 
A 1 233 HIS 233 496 496 HIS HIS A . n 
A 1 234 TRP 234 497 497 TRP TRP A . n 
A 1 235 PHE 235 498 498 PHE PHE A . n 
A 1 236 SER 236 499 499 SER SER A . n 
A 1 237 ARG 237 500 500 ARG ARG A . n 
A 1 238 GLU 238 501 501 GLU GLU A . n 
A 1 239 ASN 239 502 502 ASN ASN A . n 
A 1 240 SER 240 503 503 SER SER A . n 
A 1 241 LEU 241 504 504 LEU LEU A . n 
A 1 242 SER 242 505 505 SER SER A . n 
A 1 243 GLY 243 506 506 GLY GLY A . n 
A 1 244 VAL 244 507 507 VAL VAL A . n 
A 1 245 GLU 245 508 508 GLU GLU A . n 
A 1 246 GLY 246 509 509 GLY GLY A . n 
A 1 247 GLU 247 510 510 GLU GLU A . n 
A 1 248 GLY 248 511 511 GLY GLY A . n 
A 1 249 LEU 249 512 512 LEU LEU A . n 
A 1 250 HIS 250 513 513 HIS HIS A . n 
A 1 251 LYS 251 514 514 LYS LYS A . n 
A 1 252 LEU 252 515 515 LEU LEU A . n 
A 1 253 GLY 253 516 516 GLY GLY A . n 
A 1 254 TYR 254 517 517 TYR TYR A . n 
A 1 255 ILE 255 518 518 ILE ILE A . n 
A 1 256 LEU 256 519 519 LEU LEU A . n 
A 1 257 ARG 257 520 520 ARG ARG A . n 
A 1 258 ASP 258 521 521 ASP ASP A . n 
A 1 259 VAL 259 522 522 VAL VAL A . n 
A 1 260 SER 260 523 523 SER SER A . n 
A 1 261 LYS 261 524 524 LYS LYS A . n 
A 1 262 LYS 262 525 525 LYS LYS A . n 
A 1 263 GLU 263 526 526 GLU GLU A . n 
A 1 264 GLY 264 527 527 GLY GLY A . n 
A 1 265 GLY 265 528 528 GLY GLY A . n 
A 1 266 ALA 266 529 529 ALA ALA A . n 
A 1 267 MET 267 530 530 MET MET A . n 
A 1 268 TYR 268 531 531 TYR TYR A . n 
A 1 269 ALA 269 532 532 ALA ALA A . n 
A 1 270 ASP 270 533 533 ASP ASP A . n 
A 1 271 ASP 271 534 534 ASP ASP A . n 
A 1 272 THR 272 535 535 THR THR A . n 
A 1 273 ALA 273 536 536 ALA ALA A . n 
A 1 274 GLY 274 537 537 GLY GLY A . n 
A 1 275 TRP 275 538 538 TRP TRP A . n 
A 1 276 ASP 276 539 539 ASP ASP A . n 
A 1 277 THR 277 540 540 THR THR A . n 
A 1 278 ARG 278 541 541 ARG ARG A . n 
A 1 279 ILE 279 542 542 ILE ILE A . n 
A 1 280 THR 280 543 543 THR THR A . n 
A 1 281 LEU 281 544 544 LEU LEU A . n 
A 1 282 GLU 282 545 545 GLU GLU A . n 
A 1 283 ASP 283 546 546 ASP ASP A . n 
A 1 284 LEU 284 547 547 LEU LEU A . n 
A 1 285 LYS 285 548 548 LYS LYS A . n 
A 1 286 ASN 286 549 549 ASN ASN A . n 
A 1 287 GLU 287 550 550 GLU GLU A . n 
A 1 288 GLU 288 551 551 GLU GLU A . n 
A 1 289 MET 289 552 552 MET MET A . n 
A 1 290 VAL 290 553 553 VAL VAL A . n 
A 1 291 THR 291 554 554 THR THR A . n 
A 1 292 ASN 292 555 555 ASN ASN A . n 
A 1 293 HIS 293 556 556 HIS HIS A . n 
A 1 294 MET 294 557 557 MET MET A . n 
A 1 295 GLU 295 558 558 GLU GLU A . n 
A 1 296 GLY 296 559 559 GLY GLY A . n 
A 1 297 GLU 297 560 560 GLU GLU A . n 
A 1 298 HIS 298 561 561 HIS HIS A . n 
A 1 299 LYS 299 562 562 LYS LYS A . n 
A 1 300 LYS 300 563 563 LYS LYS A . n 
A 1 301 LEU 301 564 564 LEU LEU A . n 
A 1 302 ALA 302 565 565 ALA ALA A . n 
A 1 303 GLU 303 566 566 GLU GLU A . n 
A 1 304 ALA 304 567 567 ALA ALA A . n 
A 1 305 ILE 305 568 568 ILE ILE A . n 
A 1 306 PHE 306 569 569 PHE PHE A . n 
A 1 307 LYS 307 570 570 LYS LYS A . n 
A 1 308 LEU 308 571 571 LEU LEU A . n 
A 1 309 THR 309 572 572 THR THR A . n 
A 1 310 TYR 310 573 573 TYR TYR A . n 
A 1 311 GLN 311 574 574 GLN GLN A . n 
A 1 312 ASN 312 575 575 ASN ASN A . n 
A 1 313 LYS 313 576 576 LYS LYS A . n 
A 1 314 VAL 314 577 577 VAL VAL A . n 
A 1 315 VAL 315 578 578 VAL VAL A . n 
A 1 316 ARG 316 579 579 ARG ARG A . n 
A 1 317 VAL 317 580 580 VAL VAL A . n 
A 1 318 GLN 318 581 581 GLN GLN A . n 
A 1 319 ARG 319 582 582 ARG ARG A . n 
A 1 320 PRO 320 583 583 PRO PRO A . n 
A 1 321 THR 321 584 584 THR THR A . n 
A 1 322 PRO 322 585 ?   ?   ?   A . n 
A 1 323 ARG 323 586 ?   ?   ?   A . n 
A 1 324 GLY 324 587 ?   ?   ?   A . n 
A 1 325 THR 325 588 588 THR THR A . n 
A 1 326 VAL 326 589 589 VAL VAL A . n 
A 1 327 MET 327 590 590 MET MET A . n 
A 1 328 ASP 328 591 591 ASP ASP A . n 
A 1 329 ILE 329 592 592 ILE ILE A . n 
A 1 330 ILE 330 593 593 ILE ILE A . n 
A 1 331 SER 331 594 594 SER SER A . n 
A 1 332 ARG 332 595 595 ARG ARG A . n 
A 1 333 ARG 333 596 596 ARG ARG A . n 
A 1 334 ASP 334 597 597 ASP ASP A . n 
A 1 335 GLN 335 598 598 GLN GLN A . n 
A 1 336 ARG 336 599 599 ARG ARG A . n 
A 1 337 GLY 337 600 600 GLY GLY A . n 
A 1 338 SER 338 601 601 SER SER A . n 
A 1 339 GLY 339 602 602 GLY GLY A . n 
A 1 340 GLN 340 603 603 GLN GLN A . n 
A 1 341 VAL 341 604 604 VAL VAL A . n 
A 1 342 VAL 342 605 605 VAL VAL A . n 
A 1 343 THR 343 606 606 THR THR A . n 
A 1 344 TYR 344 607 607 TYR TYR A . n 
A 1 345 GLY 345 608 608 GLY GLY A . n 
A 1 346 LEU 346 609 609 LEU LEU A . n 
A 1 347 ASN 347 610 610 ASN ASN A . n 
A 1 348 THR 348 611 611 THR THR A . n 
A 1 349 PHE 349 612 612 PHE PHE A . n 
A 1 350 THR 350 613 613 THR THR A . n 
A 1 351 ASN 351 614 614 ASN ASN A . n 
A 1 352 MET 352 615 615 MET MET A . n 
A 1 353 GLU 353 616 616 GLU GLU A . n 
A 1 354 ALA 354 617 617 ALA ALA A . n 
A 1 355 GLN 355 618 618 GLN GLN A . n 
A 1 356 LEU 356 619 619 LEU LEU A . n 
A 1 357 ILE 357 620 620 ILE ILE A . n 
A 1 358 ARG 358 621 621 ARG ARG A . n 
A 1 359 GLN 359 622 622 GLN GLN A . n 
A 1 360 MET 360 623 623 MET MET A . n 
A 1 361 GLU 361 624 624 GLU GLU A . n 
A 1 362 GLY 362 625 625 GLY GLY A . n 
A 1 363 GLU 363 626 626 GLU GLU A . n 
A 1 364 GLY 364 627 627 GLY GLY A . n 
A 1 365 VAL 365 628 628 VAL VAL A . n 
A 1 366 PHE 366 629 629 PHE PHE A . n 
A 1 367 LYS 367 630 630 LYS LYS A . n 
A 1 368 SER 368 631 631 SER SER A . n 
A 1 369 ILE 369 632 632 ILE ILE A . n 
A 1 370 GLN 370 633 633 GLN GLN A . n 
A 1 371 HIS 371 634 634 HIS HIS A . n 
A 1 372 LEU 372 635 635 LEU LEU A . n 
A 1 373 THR 373 636 636 THR THR A . n 
A 1 374 VAL 374 637 637 VAL VAL A . n 
A 1 375 THR 375 638 638 THR THR A . n 
A 1 376 GLU 376 639 639 GLU GLU A . n 
A 1 377 GLU 377 640 640 GLU GLU A . n 
A 1 378 ILE 378 641 641 ILE ILE A . n 
A 1 379 ALA 379 642 642 ALA ALA A . n 
A 1 380 VAL 380 643 643 VAL VAL A . n 
A 1 381 LYS 381 644 644 LYS LYS A . n 
A 1 382 ASN 382 645 645 ASN ASN A . n 
A 1 383 TRP 383 646 646 TRP TRP A . n 
A 1 384 LEU 384 647 647 LEU LEU A . n 
A 1 385 VAL 385 648 648 VAL VAL A . n 
A 1 386 ARG 386 649 649 ARG ARG A . n 
A 1 387 VAL 387 650 650 VAL VAL A . n 
A 1 388 GLY 388 651 651 GLY GLY A . n 
A 1 389 ARG 389 652 652 ARG ARG A . n 
A 1 390 GLU 390 653 653 GLU GLU A . n 
A 1 391 ARG 391 654 654 ARG ARG A . n 
A 1 392 LEU 392 655 655 LEU LEU A . n 
A 1 393 SER 393 656 656 SER SER A . n 
A 1 394 ARG 394 657 657 ARG ARG A . n 
A 1 395 MET 395 658 658 MET MET A . n 
A 1 396 ALA 396 659 659 ALA ALA A . n 
A 1 397 ILE 397 660 660 ILE ILE A . n 
A 1 398 SER 398 661 661 SER SER A . n 
A 1 399 GLY 399 662 662 GLY GLY A . n 
A 1 400 ASP 400 663 663 ASP ASP A . n 
A 1 401 ASP 401 664 664 ASP ASP A . n 
A 1 402 CYS 402 665 665 CYS CYS A . n 
A 1 403 VAL 403 666 666 VAL VAL A . n 
A 1 404 VAL 404 667 667 VAL VAL A . n 
A 1 405 LYS 405 668 668 LYS LYS A . n 
A 1 406 PRO 406 669 669 PRO PRO A . n 
A 1 407 LEU 407 670 670 LEU LEU A . n 
A 1 408 ASP 408 671 671 ASP ASP A . n 
A 1 409 ASP 409 672 672 ASP ASP A . n 
A 1 410 ARG 410 673 673 ARG ARG A . n 
A 1 411 PHE 411 674 674 PHE PHE A . n 
A 1 412 ALA 412 675 675 ALA ALA A . n 
A 1 413 SER 413 676 676 SER SER A . n 
A 1 414 ALA 414 677 677 ALA ALA A . n 
A 1 415 LEU 415 678 678 LEU LEU A . n 
A 1 416 THR 416 679 679 THR THR A . n 
A 1 417 ALA 417 680 680 ALA ALA A . n 
A 1 418 LEU 418 681 681 LEU LEU A . n 
A 1 419 ASN 419 682 682 ASN ASN A . n 
A 1 420 ASP 420 683 683 ASP ASP A . n 
A 1 421 MET 421 684 684 MET MET A . n 
A 1 422 GLY 422 685 685 GLY GLY A . n 
A 1 423 LYS 423 686 686 LYS LYS A . n 
A 1 424 VAL 424 687 687 VAL VAL A . n 
A 1 425 ARG 425 688 688 ARG ARG A . n 
A 1 426 LYS 426 689 689 LYS LYS A . n 
A 1 427 ASP 427 690 690 ASP ASP A . n 
A 1 428 ILE 428 691 691 ILE ILE A . n 
A 1 429 GLN 429 692 692 GLN GLN A . n 
A 1 430 GLN 430 693 693 GLN GLN A . n 
A 1 431 TRP 431 694 694 TRP TRP A . n 
A 1 432 GLU 432 695 695 GLU GLU A . n 
A 1 433 PRO 433 696 696 PRO PRO A . n 
A 1 434 SER 434 697 697 SER SER A . n 
A 1 435 ARG 435 698 698 ARG ARG A . n 
A 1 436 GLY 436 699 699 GLY GLY A . n 
A 1 437 TRP 437 700 700 TRP TRP A . n 
A 1 438 ASN 438 701 701 ASN ASN A . n 
A 1 439 ASP 439 702 702 ASP ASP A . n 
A 1 440 TRP 440 703 703 TRP TRP A . n 
A 1 441 THR 441 704 704 THR THR A . n 
A 1 442 GLN 442 705 705 GLN GLN A . n 
A 1 443 VAL 443 706 706 VAL VAL A . n 
A 1 444 PRO 444 707 707 PRO PRO A . n 
A 1 445 PHE 445 708 708 PHE PHE A . n 
A 1 446 CYS 446 709 709 CYS CYS A . n 
A 1 447 SER 447 710 710 SER SER A . n 
A 1 448 HIS 448 711 711 HIS HIS A . n 
A 1 449 HIS 449 712 712 HIS HIS A . n 
A 1 450 PHE 450 713 713 PHE PHE A . n 
A 1 451 HIS 451 714 714 HIS HIS A . n 
A 1 452 GLU 452 715 715 GLU GLU A . n 
A 1 453 LEU 453 716 716 LEU LEU A . n 
A 1 454 ILE 454 717 717 ILE ILE A . n 
A 1 455 MET 455 718 718 MET MET A . n 
A 1 456 LYS 456 719 719 LYS LYS A . n 
A 1 457 ASP 457 720 720 ASP ASP A . n 
A 1 458 GLY 458 721 721 GLY GLY A . n 
A 1 459 ARG 459 722 722 ARG ARG A . n 
A 1 460 VAL 460 723 723 VAL VAL A . n 
A 1 461 LEU 461 724 724 LEU LEU A . n 
A 1 462 VAL 462 725 725 VAL VAL A . n 
A 1 463 VAL 463 726 726 VAL VAL A . n 
A 1 464 PRO 464 727 727 PRO PRO A . n 
A 1 465 CYS 465 728 728 CYS CYS A . n 
A 1 466 ARG 466 729 729 ARG ARG A . n 
A 1 467 ASN 467 730 730 ASN ASN A . n 
A 1 468 GLN 468 731 731 GLN GLN A . n 
A 1 469 ASP 469 732 732 ASP ASP A . n 
A 1 470 GLU 470 733 733 GLU GLU A . n 
A 1 471 LEU 471 734 734 LEU LEU A . n 
A 1 472 ILE 472 735 735 ILE ILE A . n 
A 1 473 GLY 473 736 736 GLY GLY A . n 
A 1 474 ARG 474 737 737 ARG ARG A . n 
A 1 475 ALA 475 738 738 ALA ALA A . n 
A 1 476 ARG 476 739 739 ARG ARG A . n 
A 1 477 ILE 477 740 740 ILE ILE A . n 
A 1 478 SER 478 741 741 SER SER A . n 
A 1 479 GLN 479 742 742 GLN GLN A . n 
A 1 480 GLY 480 743 743 GLY GLY A . n 
A 1 481 ALA 481 744 744 ALA ALA A . n 
A 1 482 GLY 482 745 745 GLY GLY A . n 
A 1 483 TRP 483 746 746 TRP TRP A . n 
A 1 484 SER 484 747 747 SER SER A . n 
A 1 485 LEU 485 748 748 LEU LEU A . n 
A 1 486 ARG 486 749 749 ARG ARG A . n 
A 1 487 GLU 487 750 750 GLU GLU A . n 
A 1 488 THR 488 751 751 THR THR A . n 
A 1 489 ALA 489 752 752 ALA ALA A . n 
A 1 490 CYS 490 753 753 CYS CYS A . n 
A 1 491 LEU 491 754 754 LEU LEU A . n 
A 1 492 GLY 492 755 755 GLY GLY A . n 
A 1 493 LYS 493 756 756 LYS LYS A . n 
A 1 494 SER 494 757 757 SER SER A . n 
A 1 495 TYR 495 758 758 TYR TYR A . n 
A 1 496 ALA 496 759 759 ALA ALA A . n 
A 1 497 GLN 497 760 760 GLN GLN A . n 
A 1 498 MET 498 761 761 MET MET A . n 
A 1 499 TRP 499 762 762 TRP TRP A . n 
A 1 500 SER 500 763 763 SER SER A . n 
A 1 501 LEU 501 764 764 LEU LEU A . n 
A 1 502 MET 502 765 765 MET MET A . n 
A 1 503 TYR 503 766 766 TYR TYR A . n 
A 1 504 PHE 504 767 767 PHE PHE A . n 
A 1 505 HIS 505 768 768 HIS HIS A . n 
A 1 506 ARG 506 769 769 ARG ARG A . n 
A 1 507 ARG 507 770 770 ARG ARG A . n 
A 1 508 ASP 508 771 771 ASP ASP A . n 
A 1 509 LEU 509 772 772 LEU LEU A . n 
A 1 510 ARG 510 773 773 ARG ARG A . n 
A 1 511 LEU 511 774 774 LEU LEU A . n 
A 1 512 ALA 512 775 775 ALA ALA A . n 
A 1 513 ALA 513 776 776 ALA ALA A . n 
A 1 514 ASN 514 777 777 ASN ASN A . n 
A 1 515 ALA 515 778 778 ALA ALA A . n 
A 1 516 ILE 516 779 779 ILE ILE A . n 
A 1 517 CYS 517 780 780 CYS CYS A . n 
A 1 518 SER 518 781 781 SER SER A . n 
A 1 519 ALA 519 782 782 ALA ALA A . n 
A 1 520 VAL 520 783 783 VAL VAL A . n 
A 1 521 PRO 521 784 784 PRO PRO A . n 
A 1 522 SER 522 785 785 SER SER A . n 
A 1 523 HIS 523 786 786 HIS HIS A . n 
A 1 524 TRP 524 787 787 TRP TRP A . n 
A 1 525 VAL 525 788 788 VAL VAL A . n 
A 1 526 PRO 526 789 789 PRO PRO A . n 
A 1 527 THR 527 790 790 THR THR A . n 
A 1 528 SER 528 791 791 SER SER A . n 
A 1 529 ARG 529 792 ?   ?   ?   A . n 
A 1 530 THR 530 793 ?   ?   ?   A . n 
A 1 531 THR 531 794 ?   ?   ?   A . n 
A 1 532 TRP 532 795 ?   ?   ?   A . n 
A 1 533 SER 533 796 ?   ?   ?   A . n 
A 1 534 ILE 534 797 797 ILE ILE A . n 
A 1 535 HIS 535 798 798 HIS HIS A . n 
A 1 536 ALA 536 799 799 ALA ALA A . n 
A 1 537 THR 537 800 800 THR THR A . n 
A 1 538 HIS 538 801 801 HIS HIS A . n 
A 1 539 GLU 539 802 802 GLU GLU A . n 
A 1 540 TRP 540 803 803 TRP TRP A . n 
A 1 541 MET 541 804 804 MET MET A . n 
A 1 542 THR 542 805 805 THR THR A . n 
A 1 543 THR 543 806 806 THR THR A . n 
A 1 544 GLU 544 807 807 GLU GLU A . n 
A 1 545 ASP 545 808 808 ASP ASP A . n 
A 1 546 MET 546 809 809 MET MET A . n 
A 1 547 LEU 547 810 810 LEU LEU A . n 
A 1 548 THR 548 811 811 THR THR A . n 
A 1 549 VAL 549 812 812 VAL VAL A . n 
A 1 550 TRP 550 813 813 TRP TRP A . n 
A 1 551 ASN 551 814 814 ASN ASN A . n 
A 1 552 ARG 552 815 815 ARG ARG A . n 
A 1 553 VAL 553 816 816 VAL VAL A . n 
A 1 554 TRP 554 817 817 TRP TRP A . n 
A 1 555 ILE 555 818 818 ILE ILE A . n 
A 1 556 GLN 556 819 819 GLN GLN A . n 
A 1 557 GLU 557 820 820 GLU GLU A . n 
A 1 558 ASN 558 821 821 ASN ASN A . n 
A 1 559 PRO 559 822 822 PRO PRO A . n 
A 1 560 TRP 560 823 823 TRP TRP A . n 
A 1 561 MET 561 824 824 MET MET A . n 
A 1 562 GLU 562 825 825 GLU GLU A . n 
A 1 563 ASP 563 826 826 ASP ASP A . n 
A 1 564 LYS 564 827 827 LYS LYS A . n 
A 1 565 THR 565 828 828 THR THR A . n 
A 1 566 PRO 566 829 829 PRO PRO A . n 
A 1 567 VAL 567 830 830 VAL VAL A . n 
A 1 568 GLU 568 831 831 GLU GLU A . n 
A 1 569 SER 569 832 832 SER SER A . n 
A 1 570 TRP 570 833 833 TRP TRP A . n 
A 1 571 GLU 571 834 834 GLU GLU A . n 
A 1 572 GLU 572 835 835 GLU GLU A . n 
A 1 573 ILE 573 836 836 ILE ILE A . n 
A 1 574 PRO 574 837 837 PRO PRO A . n 
A 1 575 TYR 575 838 838 TYR TYR A . n 
A 1 576 LEU 576 839 839 LEU LEU A . n 
A 1 577 GLY 577 840 840 GLY GLY A . n 
A 1 578 LYS 578 841 841 LYS LYS A . n 
A 1 579 ARG 579 842 842 ARG ARG A . n 
A 1 580 GLU 580 843 843 GLU GLU A . n 
A 1 581 ASP 581 844 844 ASP ASP A . n 
A 1 582 GLN 582 845 845 GLN GLN A . n 
A 1 583 TRP 583 846 846 TRP TRP A . n 
A 1 584 CYS 584 847 847 CYS CYS A . n 
A 1 585 GLY 585 848 848 GLY GLY A . n 
A 1 586 SER 586 849 849 SER SER A . n 
A 1 587 LEU 587 850 850 LEU LEU A . n 
A 1 588 ILE 588 851 851 ILE ILE A . n 
A 1 589 GLY 589 852 852 GLY GLY A . n 
A 1 590 LEU 590 853 853 LEU LEU A . n 
A 1 591 THR 591 854 854 THR THR A . n 
A 1 592 SER 592 855 855 SER SER A . n 
A 1 593 ARG 593 856 856 ARG ARG A . n 
A 1 594 ALA 594 857 857 ALA ALA A . n 
A 1 595 THR 595 858 858 THR THR A . n 
A 1 596 TRP 596 859 859 TRP TRP A . n 
A 1 597 ALA 597 860 860 ALA ALA A . n 
A 1 598 LYS 598 861 861 LYS LYS A . n 
A 1 599 ASN 599 862 862 ASN ASN A . n 
A 1 600 ILE 600 863 863 ILE ILE A . n 
A 1 601 GLN 601 864 864 GLN GLN A . n 
A 1 602 THR 602 865 865 THR THR A . n 
A 1 603 ALA 603 866 866 ALA ALA A . n 
A 1 604 ILE 604 867 867 ILE ILE A . n 
A 1 605 ASN 605 868 868 ASN ASN A . n 
A 1 606 GLN 606 869 869 GLN GLN A . n 
A 1 607 VAL 607 870 870 VAL VAL A . n 
A 1 608 ARG 608 871 871 ARG ARG A . n 
A 1 609 SER 609 872 872 SER SER A . n 
A 1 610 LEU 610 873 873 LEU LEU A . n 
A 1 611 ILE 611 874 874 ILE ILE A . n 
A 1 612 GLY 612 875 875 GLY GLY A . n 
A 1 613 ASN 613 876 876 ASN ASN A . n 
A 1 614 GLU 614 877 877 GLU GLU A . n 
A 1 615 GLU 615 878 878 GLU GLU A . n 
A 1 616 TYR 616 879 879 TYR TYR A . n 
A 1 617 THR 617 880 880 THR THR A . n 
A 1 618 ASP 618 881 881 ASP ASP A . n 
A 1 619 TYR 619 882 882 TYR TYR A . n 
A 1 620 MET 620 883 883 MET MET A . n 
A 1 621 PRO 621 884 884 PRO PRO A . n 
A 1 622 SER 622 885 885 SER SER A . n 
A 1 623 MET 623 886 886 MET MET A . n 
A 1 624 LYS 624 887 887 LYS LYS A . n 
A 1 625 ARG 625 888 888 ARG ARG A . n 
A 1 626 PHE 626 889 889 PHE PHE A . n 
A 1 627 ARG 627 890 890 ARG ARG A . n 
A 1 628 ARG 628 891 891 ARG ARG A . n 
A 1 629 GLU 629 892 ?   ?   ?   A . n 
A 1 630 GLU 630 893 ?   ?   ?   A . n 
A 1 631 GLU 631 894 ?   ?   ?   A . n 
A 1 632 GLU 632 895 ?   ?   ?   A . n 
A 1 633 ALA 633 896 ?   ?   ?   A . n 
A 1 634 GLY 634 897 ?   ?   ?   A . n 
A 1 635 VAL 635 898 ?   ?   ?   A . n 
A 1 636 LEU 636 899 ?   ?   ?   A . n 
A 1 637 TRP 637 900 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1BFU 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1BFU 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 ZN    1   1001 1001 ZN    ZN  A . 
C 2 ZN    1   1002 1002 ZN    ZN  A . 
D 3 MES   1   1003 1004 MES   MES A . 
E 4 DMS   1   1004 1530 DMS   DMS A . 
F 4 DMS   1   1005 1601 DMS   DMS A . 
G 5 PO4   1   1006 1604 PO4   PO4 A . 
H 5 PO4   1   1007 1606 PO4   PO4 A . 
I 6 PEG   1   1008 1607 PEG   PEG A . 
J 7 CL    1   1009 2001 CL    CL  A . 
K 8 A1BFU 1   1010 2101 A1BFU LIG A . 
L 7 CL    1   1011 1    CL    CL  A . 
M 9 HOH   1   1101 273  HOH   HOH A . 
M 9 HOH   2   1102 348  HOH   HOH A . 
M 9 HOH   3   1103 230  HOH   HOH A . 
M 9 HOH   4   1104 60   HOH   HOH A . 
M 9 HOH   5   1105 248  HOH   HOH A . 
M 9 HOH   6   1106 189  HOH   HOH A . 
M 9 HOH   7   1107 247  HOH   HOH A . 
M 9 HOH   8   1108 280  HOH   HOH A . 
M 9 HOH   9   1109 176  HOH   HOH A . 
M 9 HOH   10  1110 209  HOH   HOH A . 
M 9 HOH   11  1111 35   HOH   HOH A . 
M 9 HOH   12  1112 471  HOH   HOH A . 
M 9 HOH   13  1113 217  HOH   HOH A . 
M 9 HOH   14  1114 204  HOH   HOH A . 
M 9 HOH   15  1115 195  HOH   HOH A . 
M 9 HOH   16  1116 177  HOH   HOH A . 
M 9 HOH   17  1117 3    HOH   HOH A . 
M 9 HOH   18  1118 259  HOH   HOH A . 
M 9 HOH   19  1119 206  HOH   HOH A . 
M 9 HOH   20  1120 396  HOH   HOH A . 
M 9 HOH   21  1121 197  HOH   HOH A . 
M 9 HOH   22  1122 191  HOH   HOH A . 
M 9 HOH   23  1123 151  HOH   HOH A . 
M 9 HOH   24  1124 227  HOH   HOH A . 
M 9 HOH   25  1125 277  HOH   HOH A . 
M 9 HOH   26  1126 52   HOH   HOH A . 
M 9 HOH   27  1127 152  HOH   HOH A . 
M 9 HOH   28  1128 214  HOH   HOH A . 
M 9 HOH   29  1129 46   HOH   HOH A . 
M 9 HOH   30  1130 190  HOH   HOH A . 
M 9 HOH   31  1131 243  HOH   HOH A . 
M 9 HOH   32  1132 258  HOH   HOH A . 
M 9 HOH   33  1133 232  HOH   HOH A . 
M 9 HOH   34  1134 185  HOH   HOH A . 
M 9 HOH   35  1135 196  HOH   HOH A . 
M 9 HOH   36  1136 467  HOH   HOH A . 
M 9 HOH   37  1137 341  HOH   HOH A . 
M 9 HOH   38  1138 257  HOH   HOH A . 
M 9 HOH   39  1139 451  HOH   HOH A . 
M 9 HOH   40  1140 226  HOH   HOH A . 
M 9 HOH   41  1141 361  HOH   HOH A . 
M 9 HOH   42  1142 178  HOH   HOH A . 
M 9 HOH   43  1143 311  HOH   HOH A . 
M 9 HOH   44  1144 238  HOH   HOH A . 
M 9 HOH   45  1145 2    HOH   HOH A . 
M 9 HOH   46  1146 6    HOH   HOH A . 
M 9 HOH   47  1147 293  HOH   HOH A . 
M 9 HOH   48  1148 464  HOH   HOH A . 
M 9 HOH   49  1149 251  HOH   HOH A . 
M 9 HOH   50  1150 91   HOH   HOH A . 
M 9 HOH   51  1151 143  HOH   HOH A . 
M 9 HOH   52  1152 96   HOH   HOH A . 
M 9 HOH   53  1153 312  HOH   HOH A . 
M 9 HOH   54  1154 254  HOH   HOH A . 
M 9 HOH   55  1155 182  HOH   HOH A . 
M 9 HOH   56  1156 256  HOH   HOH A . 
M 9 HOH   57  1157 249  HOH   HOH A . 
M 9 HOH   58  1158 223  HOH   HOH A . 
M 9 HOH   59  1159 281  HOH   HOH A . 
M 9 HOH   60  1160 222  HOH   HOH A . 
M 9 HOH   61  1161 187  HOH   HOH A . 
M 9 HOH   62  1162 365  HOH   HOH A . 
M 9 HOH   63  1163 207  HOH   HOH A . 
M 9 HOH   64  1164 274  HOH   HOH A . 
M 9 HOH   65  1165 246  HOH   HOH A . 
M 9 HOH   66  1166 211  HOH   HOH A . 
M 9 HOH   67  1167 237  HOH   HOH A . 
M 9 HOH   68  1168 201  HOH   HOH A . 
M 9 HOH   69  1169 289  HOH   HOH A . 
M 9 HOH   70  1170 220  HOH   HOH A . 
M 9 HOH   71  1171 225  HOH   HOH A . 
M 9 HOH   72  1172 179  HOH   HOH A . 
M 9 HOH   73  1173 92   HOH   HOH A . 
M 9 HOH   74  1174 199  HOH   HOH A . 
M 9 HOH   75  1175 266  HOH   HOH A . 
M 9 HOH   76  1176 458  HOH   HOH A . 
M 9 HOH   77  1177 333  HOH   HOH A . 
M 9 HOH   78  1178 202  HOH   HOH A . 
M 9 HOH   79  1179 318  HOH   HOH A . 
M 9 HOH   80  1180 306  HOH   HOH A . 
M 9 HOH   81  1181 112  HOH   HOH A . 
M 9 HOH   82  1182 264  HOH   HOH A . 
M 9 HOH   83  1183 210  HOH   HOH A . 
M 9 HOH   84  1184 27   HOH   HOH A . 
M 9 HOH   85  1185 319  HOH   HOH A . 
M 9 HOH   86  1186 416  HOH   HOH A . 
M 9 HOH   87  1187 346  HOH   HOH A . 
M 9 HOH   88  1188 288  HOH   HOH A . 
M 9 HOH   89  1189 16   HOH   HOH A . 
M 9 HOH   90  1190 234  HOH   HOH A . 
M 9 HOH   91  1191 292  HOH   HOH A . 
M 9 HOH   92  1192 184  HOH   HOH A . 
M 9 HOH   93  1193 315  HOH   HOH A . 
M 9 HOH   94  1194 7    HOH   HOH A . 
M 9 HOH   95  1195 205  HOH   HOH A . 
M 9 HOH   96  1196 215  HOH   HOH A . 
M 9 HOH   97  1197 278  HOH   HOH A . 
M 9 HOH   98  1198 265  HOH   HOH A . 
M 9 HOH   99  1199 272  HOH   HOH A . 
M 9 HOH   100 1200 240  HOH   HOH A . 
M 9 HOH   101 1201 186  HOH   HOH A . 
M 9 HOH   102 1202 300  HOH   HOH A . 
M 9 HOH   103 1203 45   HOH   HOH A . 
M 9 HOH   104 1204 268  HOH   HOH A . 
M 9 HOH   105 1205 82   HOH   HOH A . 
M 9 HOH   106 1206 236  HOH   HOH A . 
M 9 HOH   107 1207 34   HOH   HOH A . 
M 9 HOH   108 1208 294  HOH   HOH A . 
M 9 HOH   109 1209 308  HOH   HOH A . 
M 9 HOH   110 1210 198  HOH   HOH A . 
M 9 HOH   111 1211 213  HOH   HOH A . 
M 9 HOH   112 1212 320  HOH   HOH A . 
M 9 HOH   113 1213 287  HOH   HOH A . 
M 9 HOH   114 1214 188  HOH   HOH A . 
M 9 HOH   115 1215 250  HOH   HOH A . 
M 9 HOH   116 1216 276  HOH   HOH A . 
M 9 HOH   117 1217 356  HOH   HOH A . 
M 9 HOH   118 1218 241  HOH   HOH A . 
M 9 HOH   119 1219 269  HOH   HOH A . 
M 9 HOH   120 1220 252  HOH   HOH A . 
M 9 HOH   121 1221 286  HOH   HOH A . 
M 9 HOH   122 1222 392  HOH   HOH A . 
M 9 HOH   123 1223 245  HOH   HOH A . 
M 9 HOH   124 1224 331  HOH   HOH A . 
M 9 HOH   125 1225 262  HOH   HOH A . 
M 9 HOH   126 1226 150  HOH   HOH A . 
M 9 HOH   127 1227 216  HOH   HOH A . 
M 9 HOH   128 1228 244  HOH   HOH A . 
M 9 HOH   129 1229 325  HOH   HOH A . 
M 9 HOH   130 1230 261  HOH   HOH A . 
M 9 HOH   131 1231 239  HOH   HOH A . 
M 9 HOH   132 1232 83   HOH   HOH A . 
M 9 HOH   133 1233 389  HOH   HOH A . 
M 9 HOH   134 1234 285  HOH   HOH A . 
M 9 HOH   135 1235 298  HOH   HOH A . 
M 9 HOH   136 1236 235  HOH   HOH A . 
M 9 HOH   137 1237 145  HOH   HOH A . 
M 9 HOH   138 1238 270  HOH   HOH A . 
M 9 HOH   139 1239 316  HOH   HOH A . 
M 9 HOH   140 1240 347  HOH   HOH A . 
M 9 HOH   141 1241 117  HOH   HOH A . 
M 9 HOH   142 1242 263  HOH   HOH A . 
M 9 HOH   143 1243 304  HOH   HOH A . 
M 9 HOH   144 1244 18   HOH   HOH A . 
M 9 HOH   145 1245 358  HOH   HOH A . 
M 9 HOH   146 1246 231  HOH   HOH A . 
M 9 HOH   147 1247 194  HOH   HOH A . 
M 9 HOH   148 1248 228  HOH   HOH A . 
M 9 HOH   149 1249 255  HOH   HOH A . 
M 9 HOH   150 1250 309  HOH   HOH A . 
M 9 HOH   151 1251 233  HOH   HOH A . 
M 9 HOH   152 1252 296  HOH   HOH A . 
M 9 HOH   153 1253 323  HOH   HOH A . 
M 9 HOH   154 1254 321  HOH   HOH A . 
M 9 HOH   155 1255 314  HOH   HOH A . 
M 9 HOH   156 1256 367  HOH   HOH A . 
M 9 HOH   157 1257 5    HOH   HOH A . 
M 9 HOH   158 1258 30   HOH   HOH A . 
M 9 HOH   159 1259 322  HOH   HOH A . 
M 9 HOH   160 1260 357  HOH   HOH A . 
M 9 HOH   161 1261 355  HOH   HOH A . 
M 9 HOH   162 1262 271  HOH   HOH A . 
M 9 HOH   163 1263 368  HOH   HOH A . 
M 9 HOH   164 1264 136  HOH   HOH A . 
M 9 HOH   165 1265 39   HOH   HOH A . 
M 9 HOH   166 1266 290  HOH   HOH A . 
M 9 HOH   167 1267 218  HOH   HOH A . 
M 9 HOH   168 1268 212  HOH   HOH A . 
M 9 HOH   169 1269 350  HOH   HOH A . 
M 9 HOH   170 1270 260  HOH   HOH A . 
M 9 HOH   171 1271 284  HOH   HOH A . 
M 9 HOH   172 1272 330  HOH   HOH A . 
M 9 HOH   173 1273 29   HOH   HOH A . 
M 9 HOH   174 1274 339  HOH   HOH A . 
M 9 HOH   175 1275 69   HOH   HOH A . 
M 9 HOH   176 1276 120  HOH   HOH A . 
M 9 HOH   177 1277 148  HOH   HOH A . 
M 9 HOH   178 1278 328  HOH   HOH A . 
M 9 HOH   179 1279 373  HOH   HOH A . 
M 9 HOH   180 1280 4    HOH   HOH A . 
M 9 HOH   181 1281 282  HOH   HOH A . 
M 9 HOH   182 1282 394  HOH   HOH A . 
M 9 HOH   183 1283 378  HOH   HOH A . 
M 9 HOH   184 1284 363  HOH   HOH A . 
M 9 HOH   185 1285 203  HOH   HOH A . 
M 9 HOH   186 1286 351  HOH   HOH A . 
M 9 HOH   187 1287 47   HOH   HOH A . 
M 9 HOH   188 1288 335  HOH   HOH A . 
M 9 HOH   189 1289 33   HOH   HOH A . 
M 9 HOH   190 1290 62   HOH   HOH A . 
M 9 HOH   191 1291 70   HOH   HOH A . 
M 9 HOH   192 1292 127  HOH   HOH A . 
M 9 HOH   193 1293 360  HOH   HOH A . 
M 9 HOH   194 1294 379  HOH   HOH A . 
M 9 HOH   195 1295 334  HOH   HOH A . 
M 9 HOH   196 1296 305  HOH   HOH A . 
M 9 HOH   197 1297 40   HOH   HOH A . 
M 9 HOH   198 1298 364  HOH   HOH A . 
M 9 HOH   199 1299 42   HOH   HOH A . 
M 9 HOH   200 1300 67   HOH   HOH A . 
M 9 HOH   201 1301 375  HOH   HOH A . 
M 9 HOH   202 1302 224  HOH   HOH A . 
M 9 HOH   203 1303 297  HOH   HOH A . 
M 9 HOH   204 1304 291  HOH   HOH A . 
M 9 HOH   205 1305 388  HOH   HOH A . 
M 9 HOH   206 1306 383  HOH   HOH A . 
M 9 HOH   207 1307 313  HOH   HOH A . 
M 9 HOH   208 1308 468  HOH   HOH A . 
M 9 HOH   209 1309 38   HOH   HOH A . 
M 9 HOH   210 1310 402  HOH   HOH A . 
M 9 HOH   211 1311 377  HOH   HOH A . 
M 9 HOH   212 1312 354  HOH   HOH A . 
M 9 HOH   213 1313 386  HOH   HOH A . 
M 9 HOH   214 1314 14   HOH   HOH A . 
M 9 HOH   215 1315 369  HOH   HOH A . 
M 9 HOH   216 1316 366  HOH   HOH A . 
M 9 HOH   217 1317 344  HOH   HOH A . 
M 9 HOH   218 1318 381  HOH   HOH A . 
M 9 HOH   219 1319 374  HOH   HOH A . 
M 9 HOH   220 1320 175  HOH   HOH A . 
M 9 HOH   221 1321 110  HOH   HOH A . 
M 9 HOH   222 1322 393  HOH   HOH A . 
M 9 HOH   223 1323 1    HOH   HOH A . 
M 9 HOH   224 1324 32   HOH   HOH A . 
M 9 HOH   225 1325 384  HOH   HOH A . 
M 9 HOH   226 1326 380  HOH   HOH A . 
M 9 HOH   227 1327 372  HOH   HOH A . 
M 9 HOH   228 1328 376  HOH   HOH A . 
M 9 HOH   229 1329 352  HOH   HOH A . 
M 9 HOH   230 1330 307  HOH   HOH A . 
M 9 HOH   231 1331 465  HOH   HOH A . 
M 9 HOH   232 1332 100  HOH   HOH A . 
M 9 HOH   233 1333 116  HOH   HOH A . 
M 9 HOH   234 1334 106  HOH   HOH A . 
M 9 HOH   235 1335 403  HOH   HOH A . 
M 9 HOH   236 1336 24   HOH   HOH A . 
M 9 HOH   237 1337 371  HOH   HOH A . 
M 9 HOH   238 1338 466  HOH   HOH A . 
M 9 HOH   239 1339 275  HOH   HOH A . 
M 9 HOH   240 1340 411  HOH   HOH A . 
M 9 HOH   241 1341 399  HOH   HOH A . 
M 9 HOH   242 1342 406  HOH   HOH A . 
M 9 HOH   243 1343 15   HOH   HOH A . 
M 9 HOH   244 1344 349  HOH   HOH A . 
M 9 HOH   245 1345 404  HOH   HOH A . 
M 9 HOH   246 1346 98   HOH   HOH A . 
M 9 HOH   247 1347 462  HOH   HOH A . 
M 9 HOH   248 1348 56   HOH   HOH A . 
M 9 HOH   249 1349 398  HOH   HOH A . 
M 9 HOH   250 1350 412  HOH   HOH A . 
M 9 HOH   251 1351 295  HOH   HOH A . 
M 9 HOH   252 1352 338  HOH   HOH A . 
M 9 HOH   253 1353 326  HOH   HOH A . 
M 9 HOH   254 1354 409  HOH   HOH A . 
M 9 HOH   255 1355 137  HOH   HOH A . 
M 9 HOH   256 1356 340  HOH   HOH A . 
M 9 HOH   257 1357 299  HOH   HOH A . 
M 9 HOH   258 1358 359  HOH   HOH A . 
M 9 HOH   259 1359 114  HOH   HOH A . 
M 9 HOH   260 1360 444  HOH   HOH A . 
M 9 HOH   261 1361 118  HOH   HOH A . 
M 9 HOH   262 1362 342  HOH   HOH A . 
M 9 HOH   263 1363 157  HOH   HOH A . 
M 9 HOH   264 1364 279  HOH   HOH A . 
M 9 HOH   265 1365 332  HOH   HOH A . 
M 9 HOH   266 1366 418  HOH   HOH A . 
M 9 HOH   267 1367 422  HOH   HOH A . 
M 9 HOH   268 1368 72   HOH   HOH A . 
M 9 HOH   269 1369 456  HOH   HOH A . 
M 9 HOH   270 1370 415  HOH   HOH A . 
M 9 HOH   271 1371 390  HOH   HOH A . 
M 9 HOH   272 1372 80   HOH   HOH A . 
M 9 HOH   273 1373 469  HOH   HOH A . 
M 9 HOH   274 1374 324  HOH   HOH A . 
M 9 HOH   275 1375 391  HOH   HOH A . 
M 9 HOH   276 1376 99   HOH   HOH A . 
M 9 HOH   277 1377 28   HOH   HOH A . 
M 9 HOH   278 1378 159  HOH   HOH A . 
M 9 HOH   279 1379 410  HOH   HOH A . 
M 9 HOH   280 1380 68   HOH   HOH A . 
M 9 HOH   281 1381 132  HOH   HOH A . 
M 9 HOH   282 1382 97   HOH   HOH A . 
M 9 HOH   283 1383 461  HOH   HOH A . 
M 9 HOH   284 1384 63   HOH   HOH A . 
M 9 HOH   285 1385 439  HOH   HOH A . 
M 9 HOH   286 1386 423  HOH   HOH A . 
M 9 HOH   287 1387 434  HOH   HOH A . 
M 9 HOH   288 1388 417  HOH   HOH A . 
M 9 HOH   289 1389 436  HOH   HOH A . 
M 9 HOH   290 1390 431  HOH   HOH A . 
M 9 HOH   291 1391 414  HOH   HOH A . 
M 9 HOH   292 1392 438  HOH   HOH A . 
M 9 HOH   293 1393 126  HOH   HOH A . 
M 9 HOH   294 1394 430  HOH   HOH A . 
M 9 HOH   295 1395 111  HOH   HOH A . 
M 9 HOH   296 1396 407  HOH   HOH A . 
M 9 HOH   297 1397 420  HOH   HOH A . 
M 9 HOH   298 1398 131  HOH   HOH A . 
M 9 HOH   299 1399 428  HOH   HOH A . 
M 9 HOH   300 1400 437  HOH   HOH A . 
M 9 HOH   301 1401 424  HOH   HOH A . 
M 9 HOH   302 1402 301  HOH   HOH A . 
M 9 HOH   303 1403 442  HOH   HOH A . 
M 9 HOH   304 1404 123  HOH   HOH A . 
M 9 HOH   305 1405 435  HOH   HOH A . 
M 9 HOH   306 1406 130  HOH   HOH A . 
M 9 HOH   307 1407 329  HOH   HOH A . 
M 9 HOH   308 1408 426  HOH   HOH A . 
M 9 HOH   309 1409 61   HOH   HOH A . 
M 9 HOH   310 1410 51   HOH   HOH A . 
M 9 HOH   311 1411 88   HOH   HOH A . 
M 9 HOH   312 1412 43   HOH   HOH A . 
M 9 HOH   313 1413 208  HOH   HOH A . 
M 9 HOH   314 1414 397  HOH   HOH A . 
M 9 HOH   315 1415 443  HOH   HOH A . 
M 9 HOH   316 1416 121  HOH   HOH A . 
M 9 HOH   317 1417 8    HOH   HOH A . 
M 9 HOH   318 1418 53   HOH   HOH A . 
M 9 HOH   319 1419 445  HOH   HOH A . 
M 9 HOH   320 1420 470  HOH   HOH A . 
M 9 HOH   321 1421 64   HOH   HOH A . 
M 9 HOH   322 1422 78   HOH   HOH A . 
M 9 HOH   323 1423 441  HOH   HOH A . 
M 9 HOH   324 1424 449  HOH   HOH A . 
M 9 HOH   325 1425 12   HOH   HOH A . 
M 9 HOH   326 1426 447  HOH   HOH A . 
M 9 HOH   327 1427 440  HOH   HOH A . 
M 9 HOH   328 1428 135  HOH   HOH A . 
M 9 HOH   329 1429 49   HOH   HOH A . 
M 9 HOH   330 1430 9    HOH   HOH A . 
M 9 HOH   331 1431 17   HOH   HOH A . 
M 9 HOH   332 1432 95   HOH   HOH A . 
M 9 HOH   333 1433 200  HOH   HOH A . 
M 9 HOH   334 1434 450  HOH   HOH A . 
M 9 HOH   335 1435 73   HOH   HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A THR 344 ? CB  ? A THR 81 CB  
2 1 Y 1 A THR 344 ? OG1 ? A THR 81 OG1 
3 1 Y 1 A THR 344 ? CG2 ? A THR 81 CG2 
# 
loop_
_software.classification 
_software.name 
_software.version 
_software.citation_id 
_software.pdbx_ordinal 
_software.date 
_software.type 
_software.location 
_software.language 
refinement       REFMAC  5.8.0267 ? 1 ? ? ? ? 
'data scaling'   Aimless .        ? 2 ? ? ? ? 
phasing          PHASER  .        ? 3 ? ? ? ? 
'data reduction' XDS     .        ? 4 ? ? ? ? 
# 
_cell.entry_id           7I2K 
_cell.length_a           82.275 
_cell.length_b           116.039 
_cell.length_c           147.914 
_cell.angle_alpha        90.00 
_cell.angle_beta         90.00 
_cell.angle_gamma        90.00 
_cell.Z_PDB              8 
_cell.pdbx_unique_axis   ? 
# 
_symmetry.entry_id                         7I2K 
_symmetry.space_group_name_H-M             'I 2 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                23 
# 
_exptl.entry_id          7I2K 
_exptl.method            'X-RAY DIFFRACTION' 
_exptl.crystals_number   1 
# 
_exptl_crystal.id                    1 
_exptl_crystal.density_meas          ? 
_exptl_crystal.density_Matthews      2.39 
_exptl_crystal.density_percent_sol   48.51 
_exptl_crystal.description           ? 
_exptl_crystal.preparation           ? 
# 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.temp            293.15 
_exptl_crystal_grow.pdbx_details    '350 mM Magnesium chloride, 10% PEG 4000, 100 mM MES, pH 6.5' 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.pdbx_pH_range   ? 
# 
_diffrn.id                               1 
_diffrn.ambient_temp                     100 
_diffrn.crystal_id                       1 
_diffrn.ambient_temp_details             ? 
_diffrn.pdbx_serial_crystal_experiment   ? 
# 
_diffrn_detector.detector               PIXEL 
_diffrn_detector.type                   'DECTRIS EIGER2 XE 9M' 
_diffrn_detector.pdbx_collection_date   2023-12-02 
_diffrn_detector.diffrn_id              1 
_diffrn_detector.details                ? 
# 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.92124 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.diffrn_id                   1 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.type                        'DIAMOND BEAMLINE I04-1' 
_diffrn_source.pdbx_wavelength_list        0.92124 
_diffrn_source.pdbx_synchrotron_site       Diamond 
_diffrn_source.pdbx_synchrotron_beamline   I04-1 
_diffrn_source.pdbx_wavelength             ? 
# 
_reflns.entry_id                     7I2K 
_reflns.pdbx_diffrn_id               1 
_reflns.pdbx_ordinal                 1 
_reflns.d_resolution_low             91.27 
_reflns.d_resolution_high            1.90 
_reflns.number_obs                   55818 
_reflns.percent_possible_obs         99.9 
_reflns.pdbx_Rmerge_I_obs            0.253 
_reflns.pdbx_netI_over_sigmaI        7.7 
_reflns.pdbx_redundancy              13.7 
_reflns.pdbx_Rrim_I_all              0.262 
_reflns.pdbx_Rpim_I_all              0.070 
_reflns.pdbx_CC_half                 0.997 
_reflns.pdbx_number_measured_all     765064 
_reflns.pdbx_chi_squared             0.41 
_reflns.observed_criterion_sigma_I   ? 
_reflns.observed_criterion_sigma_F   ? 
_reflns.number_all                   ? 
_reflns.pdbx_Rsym_value              ? 
_reflns.B_iso_Wilson_estimate        ? 
_reflns.pdbx_CC_star                 ? 
# 
_reflns_shell.pdbx_diffrn_id              1 
_reflns_shell.pdbx_ordinal                1 
_reflns_shell.d_res_high                  1.90 
_reflns_shell.d_res_low                   1.94 
_reflns_shell.number_measured_all         47400 
_reflns_shell.number_unique_obs           3475 
_reflns_shell.Rmerge_I_obs                5.242 
_reflns_shell.pdbx_chi_squared            0.21 
_reflns_shell.pdbx_redundancy             13.6 
_reflns_shell.percent_possible_obs        98.3 
_reflns_shell.pdbx_netI_over_sigmaI_obs   0.4 
_reflns_shell.pdbx_Rrim_I_all             5.445 
_reflns_shell.pdbx_Rpim_I_all             1.466 
_reflns_shell.pdbx_CC_half                0.355 
_reflns_shell.percent_possible_all        ? 
_reflns_shell.pdbx_Rsym_value             ? 
_reflns_shell.meanI_over_sigI_obs         ? 
_reflns_shell.number_measured_obs         ? 
_reflns_shell.number_unique_all           ? 
_reflns_shell.pdbx_CC_star                ? 
# 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.entry_id                                 7I2K 
_refine.pdbx_diffrn_id                           1 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     52636 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             91.30 
_refine.ls_d_res_high                            1.90 
_refine.ls_percent_reflns_obs                    99.21 
_refine.ls_R_factor_obs                          0.19965 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       0.19741 
_refine.ls_R_factor_R_free                       0.23993 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 5.1 
_refine.ls_number_reflns_R_free                  2851 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               0.961 
_refine.correlation_coeff_Fo_to_Fc_free          0.947 
_refine.B_iso_mean                               58.066 
_refine.aniso_B[1][1]                            -2.07 
_refine.aniso_B[2][2]                            0.72 
_refine.aniso_B[3][3]                            1.35 
_refine.aniso_B[1][2]                            -0.00 
_refine.aniso_B[1][3]                            0.00 
_refine.aniso_B[2][3]                            -0.00 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_overall_ESU_R                       0.315 
_refine.pdbx_overall_ESU_R_Free                  0.199 
_refine.overall_SU_ML                            0.237 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             9.334 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.pdbx_number_atoms_protein        4678 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         55 
_refine_hist.number_atoms_solvent             335 
_refine_hist.number_atoms_total               5068 
_refine_hist.d_res_high                       1.90 
_refine_hist.d_res_low                        91.30 
# 
loop_
_refine_ls_restr.type 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.weight 
_refine_ls_restr.number 
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.pdbx_restraint_function 
r_bond_refined_d             0.006  0.014  ? 12316 'X-RAY DIFFRACTION' ? 
r_bond_other_d               0.001  0.015  ? 8706  'X-RAY DIFFRACTION' ? 
r_angle_refined_deg          1.404  1.648  ? 12776 'X-RAY DIFFRACTION' ? 
r_angle_other_deg            1.190  1.604  ? 20195 'X-RAY DIFFRACTION' ? 
r_dihedral_angle_1_deg       6.464  5.000  ? 1196  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_2_deg       31.580 21.426 ? 554   'X-RAY DIFFRACTION' ? 
r_dihedral_angle_3_deg       17.074 15.000 ? 1762  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_4_deg       17.948 15.000 ? 86    'X-RAY DIFFRACTION' ? 
r_chiral_restr               0.060  0.200  ? 1152  'X-RAY DIFFRACTION' ? 
r_gen_planes_refined         0.006  0.020  ? 11077 'X-RAY DIFFRACTION' ? 
r_gen_planes_other           0.001  0.020  ? 2355  'X-RAY DIFFRACTION' ? 
r_nbd_refined                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbd_other                  ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_refined              ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_other                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_refined        ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_other          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_refined          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_other            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_refined       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_other         ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_refined     ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_other       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_refined ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_other   ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_mcbond_it                  2.782  5.890  ? 5893  'X-RAY DIFFRACTION' ? 
r_mcbond_other               2.813  5.910  ? 5765  'X-RAY DIFFRACTION' ? 
r_mcangle_it                 5.182  8.411  ? 5742  'X-RAY DIFFRACTION' ? 
r_mcangle_other              5.181  8.412  ? 5743  'X-RAY DIFFRACTION' ? 
r_scbond_it                  2.938  6.427  ? 6423  'X-RAY DIFFRACTION' ? 
r_scbond_other               2.938  6.428  ? 6423  'X-RAY DIFFRACTION' ? 
r_scangle_it                 ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_scangle_other              5.145  9.323  ? 7031  'X-RAY DIFFRACTION' ? 
r_long_range_B_refined       8.384  48.078 ? 9229  'X-RAY DIFFRACTION' ? 
r_long_range_B_other         8.157  47.704 ? 9077  'X-RAY DIFFRACTION' ? 
r_rigid_bond_restr           ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_free            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_bonded          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.d_res_high                       1.901 
_refine_ls_shell.d_res_low                        1.951 
_refine_ls_shell.number_reflns_R_work             3504 
_refine_ls_shell.R_factor_R_work                  0.399 
_refine_ls_shell.percent_reflns_obs               91.27 
_refine_ls_shell.R_factor_R_free                  0.398 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.number_reflns_R_free             206 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.number_reflns_obs                ? 
# 
_struct.entry_id                  7I2K 
_struct.title                     
;Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z1343518214 (DNV2_NS5A-x0503)
;
_struct.pdbx_model_details        ? 
_struct.pdbx_CASP_flag            ? 
_struct.pdbx_model_type_details   ? 
# 
_struct_keywords.entry_id        7I2K 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
_struct_keywords.text            
;Diamond Light Source, I04-1, READDI, Dengue Virus, crystallographic fragment screening, PanDDA, XChemExplorer, cluster4x, VIRAL PROTEIN
;
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 5 ? 
H N N 5 ? 
I N N 6 ? 
J N N 7 ? 
K N N 8 ? 
L N N 7 ? 
M N N 9 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q91H74_9FLAV 
_struct_ref.pdbx_db_accession          Q91H74 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;GIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAMTD
TTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAREA
VEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLS
GVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRPTP
RGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGDDC
VVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQGAG
WSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPWME
DKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_struct_ref.pdbx_align_begin           2757 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              7I2K 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 3 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 637 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q91H74 
_struct_ref_seq.db_align_beg                  2757 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3391 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       266 
_struct_ref_seq.pdbx_auth_seq_align_end       900 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 7I2K GLY A 1 ? UNP Q91H74 ? ? 'expression tag' 264 1 
1 7I2K PRO A 2 ? UNP Q91H74 ? ? 'expression tag' 265 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 10  ? HIS A 25  ? ASN A 273 HIS A 288 1 ? 16 
HELX_P HELX_P2  AA2 GLU A 26  ? TRP A 29  ? GLU A 289 TRP A 292 5 ? 4  
HELX_P HELX_P3  AA3 ASN A 59  ? LEU A 65  ? ASN A 322 LEU A 328 1 ? 7  
HELX_P HELX_P4  AA4 THR A 66  ? ILE A 71  ? THR A 329 ILE A 334 5 ? 6  
HELX_P HELX_P5  AA5 ILE A 72  ? GLN A 77  ? ILE A 335 GLN A 340 1 ? 6  
HELX_P HELX_P6  AA6 MET A 78  ? MET A 80  ? MET A 341 MET A 343 5 ? 3  
HELX_P HELX_P7  AA7 LYS A 104 ? LYS A 124 ? LYS A 367 LYS A 387 1 ? 21 
HELX_P HELX_P8  AA8 THR A 132 ? SER A 142 ? THR A 395 SER A 405 1 ? 11 
HELX_P HELX_P9  AA9 SER A 158 ? GLU A 164 ? SER A 421 GLU A 427 1 ? 7  
HELX_P HELX_P10 AB1 ASP A 165 ? GLU A 181 ? ASP A 428 GLU A 444 1 ? 17 
HELX_P HELX_P11 AB2 TRP A 215 ? GLY A 227 ? TRP A 478 GLY A 490 1 ? 13 
HELX_P HELX_P12 AB3 GLY A 227 ? ASP A 232 ? GLY A 490 ASP A 495 1 ? 6  
HELX_P HELX_P13 AB4 GLY A 248 ? LYS A 261 ? GLY A 511 LYS A 524 1 ? 14 
HELX_P HELX_P14 AB5 GLY A 274 ? ILE A 279 ? GLY A 537 ILE A 542 5 ? 6  
HELX_P HELX_P15 AB6 THR A 280 ? MET A 289 ? THR A 543 MET A 552 1 ? 10 
HELX_P HELX_P16 AB7 VAL A 290 ? MET A 294 ? VAL A 553 MET A 557 5 ? 5  
HELX_P HELX_P17 AB8 GLU A 295 ? TYR A 310 ? GLU A 558 TYR A 573 1 ? 16 
HELX_P HELX_P18 AB9 GLY A 339 ? GLU A 363 ? GLY A 602 GLU A 626 1 ? 25 
HELX_P HELX_P19 AC1 THR A 373 ? SER A 393 ? THR A 636 SER A 656 1 ? 21 
HELX_P HELX_P20 AC2 ASP A 408 ? ALA A 414 ? ASP A 671 ALA A 677 5 ? 7  
HELX_P HELX_P21 AC3 LEU A 415 ? MET A 421 ? LEU A 678 MET A 684 1 ? 7  
HELX_P HELX_P22 AC4 ASP A 439 ? VAL A 443 ? ASP A 702 VAL A 706 5 ? 5  
HELX_P HELX_P23 AC5 ASN A 467 ? ARG A 476 ? ASN A 730 ARG A 739 1 ? 10 
HELX_P HELX_P24 AC6 SER A 484 ? TYR A 503 ? SER A 747 TYR A 766 1 ? 20 
HELX_P HELX_P25 AC7 ARG A 506 ? VAL A 520 ? ARG A 769 VAL A 783 1 ? 15 
HELX_P HELX_P26 AC8 ASP A 545 ? ILE A 555 ? ASP A 808 ILE A 818 1 ? 11 
HELX_P HELX_P27 AC9 SER A 569 ? ILE A 573 ? SER A 832 ILE A 836 5 ? 5  
HELX_P HELX_P28 AD1 GLY A 577 ? CYS A 584 ? GLY A 840 CYS A 847 1 ? 8  
HELX_P HELX_P29 AD2 LEU A 590 ? ASN A 599 ? LEU A 853 ASN A 862 1 ? 10 
HELX_P HELX_P30 AD3 ASN A 599 ? GLY A 612 ? ASN A 862 GLY A 875 1 ? 14 
HELX_P HELX_P31 AD4 TYR A 619 ? ARG A 627 ? TYR A 882 ARG A 890 5 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A HIS 179 NE2 ? ? ? 1_555 C ZN . ZN ? ? A HIS 442 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.125 ? ? 
metalc2 metalc ? ? A CYS 184 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 447 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.244 ? ? 
metalc3 metalc ? ? A CYS 187 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 450 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.263 ? ? 
metalc4 metalc ? ? A HIS 449 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 712 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.064 ? ? 
metalc5 metalc ? ? A HIS 451 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 714 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.034 ? ? 
metalc6 metalc ? ? A CYS 465 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 728 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.342 ? ? 
metalc7 metalc ? ? A CYS 584 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 847 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.424 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1 NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 118.5 ? 
2 NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 114.2 ? 
3 SG  ? A CYS 184 ? A CYS 447 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 110.6 ? 
4 NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 101.7 ? 
5 NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 104.0 ? 
6 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 108.6 ? 
7 NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 98.8  ? 
8 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 118.1 ? 
9 SG  ? A CYS 465 ? A CYS 728 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 121.8 ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 41  ? GLU A 47  ? ALA A 304 GLU A 310 
AA1 2 VAL A 326 ? ARG A 332 ? VAL A 589 ARG A 595 
AA1 3 LYS A 313 ? ARG A 319 ? LYS A 576 ARG A 582 
AA1 4 TYR A 189 ? ASN A 190 ? TYR A 452 ASN A 453 
AA2 1 MET A 57  ? VAL A 58  ? MET A 320 VAL A 321 
AA2 2 ILE A 477 ? SER A 478 ? ILE A 740 SER A 741 
AA3 1 MET A 395 ? SER A 398 ? MET A 658 SER A 661 
AA3 2 ASP A 401 ? VAL A 404 ? ASP A 664 VAL A 667 
AA4 1 HIS A 449 ? ILE A 454 ? HIS A 712 ILE A 717 
AA4 2 VAL A 460 ? CYS A 465 ? VAL A 723 CYS A 728 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ALA A 41  ? N ALA A 304 O SER A 331 ? O SER A 594 
AA1 2 3 O ILE A 330 ? O ILE A 593 N VAL A 315 ? N VAL A 578 
AA1 3 4 O VAL A 314 ? O VAL A 577 N TYR A 189 ? N TYR A 452 
AA2 1 2 N MET A 57  ? N MET A 320 O SER A 478 ? O SER A 741 
AA3 1 2 N SER A 398 ? N SER A 661 O ASP A 401 ? O ASP A 664 
AA4 1 2 N LEU A 453 ? N LEU A 716 O LEU A 461 ? O LEU A 724 
# 
_pdbx_entry_details.entry_id                   7I2K 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O   A HOH 1271 ? ? O  A HOH 1379 ? ? 1.93 
2 1 OD1 A ASP 664  ? ? O4 A PO4 1006 ? ? 1.93 
3 1 OD1 A ASP 534  ? ? O4 A PO4 1006 ? ? 2.08 
# 
_pdbx_validate_rmsd_bond.id                        1 
_pdbx_validate_rmsd_bond.PDB_model_num             1 
_pdbx_validate_rmsd_bond.auth_atom_id_1            CD 
_pdbx_validate_rmsd_bond.auth_asym_id_1            A 
_pdbx_validate_rmsd_bond.auth_comp_id_1            GLU 
_pdbx_validate_rmsd_bond.auth_seq_id_1             510 
_pdbx_validate_rmsd_bond.PDB_ins_code_1            ? 
_pdbx_validate_rmsd_bond.label_alt_id_1            ? 
_pdbx_validate_rmsd_bond.auth_atom_id_2            OE2 
_pdbx_validate_rmsd_bond.auth_asym_id_2            A 
_pdbx_validate_rmsd_bond.auth_comp_id_2            GLU 
_pdbx_validate_rmsd_bond.auth_seq_id_2             510 
_pdbx_validate_rmsd_bond.PDB_ins_code_2            ? 
_pdbx_validate_rmsd_bond.label_alt_id_2            ? 
_pdbx_validate_rmsd_bond.bond_value                1.331 
_pdbx_validate_rmsd_bond.bond_target_value         1.252 
_pdbx_validate_rmsd_bond.bond_deviation            0.079 
_pdbx_validate_rmsd_bond.bond_standard_deviation   0.011 
_pdbx_validate_rmsd_bond.linker_flag               N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 LYS A 301 ? ? -146.03 -10.51  
2  1 ASP A 360 ? ? -83.65  44.75   
3  1 GLN A 364 ? ? -69.03  -177.47 
4  1 ASN A 406 ? ? 65.21   101.34  
5  1 ALA A 408 ? ? -66.33  99.99   
6  1 LYS A 420 ? ? -65.40  -74.25  
7  1 LEU A 504 ? ? -58.16  -7.29   
8  1 ARG A 596 ? ? -98.92  -63.19  
9  1 GLN A 598 ? ? 88.98   155.96  
10 1 ASP A 690 ? ? 30.69   63.55   
11 1 ILE A 818 ? ? -117.18 -72.19  
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A MES 1003 ? D MES . 
2 1 A MES 1003 ? D MES . 
3 1 A HOH 1166 ? M HOH . 
4 1 A HOH 1246 ? M HOH . 
5 1 A HOH 1365 ? M HOH . 
6 1 A HOH 1392 ? M HOH . 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 1434 ? 6.05 . 
2 1 O ? A HOH 1435 ? 6.17 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 264 ? A GLY 1   
2  1 Y 1 A PRO 265 ? A PRO 2   
3  1 Y 1 A GLY 266 ? A GLY 3   
4  1 Y 1 A ILE 267 ? A ILE 4   
5  1 Y 1 A GLU 268 ? A GLU 5   
6  1 Y 1 A SER 269 ? A SER 6   
7  1 Y 1 A GLU 270 ? A GLU 7   
8  1 Y 1 A THR 271 ? A THR 8   
9  1 Y 1 A PRO 272 ? A PRO 9   
10 1 Y 1 A GLN 313 ? A GLN 50  
11 1 Y 1 A THR 314 ? A THR 51  
12 1 Y 1 A GLY 315 ? A GLY 52  
13 1 Y 1 A SER 316 ? A SER 53  
14 1 Y 1 A ALA 317 ? A ALA 54  
15 1 Y 1 A SER 318 ? A SER 55  
16 1 Y 1 A ASP 345 ? A ASP 82  
17 1 Y 1 A THR 346 ? A THR 83  
18 1 Y 1 A THR 347 ? A THR 84  
19 1 Y 1 A PRO 348 ? A PRO 85  
20 1 Y 1 A PHE 349 ? A PHE 86  
21 1 Y 1 A GLY 350 ? A GLY 87  
22 1 Y 1 A GLN 351 ? A GLN 88  
23 1 Y 1 A GLN 352 ? A GLN 89  
24 1 Y 1 A ARG 353 ? A ARG 90  
25 1 Y 1 A VAL 354 ? A VAL 91  
26 1 Y 1 A PHE 355 ? A PHE 92  
27 1 Y 1 A PHE 413 ? A PHE 150 
28 1 Y 1 A THR 414 ? A THR 151 
29 1 Y 1 A ASP 415 ? A ASP 152 
30 1 Y 1 A GLU 416 ? A GLU 153 
31 1 Y 1 A ASN 417 ? A ASN 154 
32 1 Y 1 A GLY 456 ? A GLY 193 
33 1 Y 1 A LYS 457 ? A LYS 194 
34 1 Y 1 A ARG 458 ? A ARG 195 
35 1 Y 1 A GLU 459 ? A GLU 196 
36 1 Y 1 A LYS 460 ? A LYS 197 
37 1 Y 1 A LYS 461 ? A LYS 198 
38 1 Y 1 A LEU 462 ? A LEU 199 
39 1 Y 1 A GLY 463 ? A GLY 200 
40 1 Y 1 A GLU 464 ? A GLU 201 
41 1 Y 1 A PHE 465 ? A PHE 202 
42 1 Y 1 A GLY 466 ? A GLY 203 
43 1 Y 1 A LYS 467 ? A LYS 204 
44 1 Y 1 A ALA 468 ? A ALA 205 
45 1 Y 1 A LYS 469 ? A LYS 206 
46 1 Y 1 A GLY 470 ? A GLY 207 
47 1 Y 1 A SER 471 ? A SER 208 
48 1 Y 1 A ARG 472 ? A ARG 209 
49 1 Y 1 A PRO 585 ? A PRO 322 
50 1 Y 1 A ARG 586 ? A ARG 323 
51 1 Y 1 A GLY 587 ? A GLY 324 
52 1 Y 1 A ARG 792 ? A ARG 529 
53 1 Y 1 A THR 793 ? A THR 530 
54 1 Y 1 A THR 794 ? A THR 531 
55 1 Y 1 A TRP 795 ? A TRP 532 
56 1 Y 1 A SER 796 ? A SER 533 
57 1 Y 1 A GLU 892 ? A GLU 629 
58 1 Y 1 A GLU 893 ? A GLU 630 
59 1 Y 1 A GLU 894 ? A GLU 631 
60 1 Y 1 A GLU 895 ? A GLU 632 
61 1 Y 1 A ALA 896 ? A ALA 633 
62 1 Y 1 A GLY 897 ? A GLY 634 
63 1 Y 1 A VAL 898 ? A VAL 635 
64 1 Y 1 A LEU 899 ? A LEU 636 
65 1 Y 1 A TRP 900 ? A TRP 637 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1BFU N1   N  N N 1   
A1BFU C4   C  N N 2   
A1BFU C5   C  N N 3   
A1BFU C6   C  N N 4   
A1BFU C7   C  N N 5   
A1BFU C8   C  N N 6   
A1BFU C1   C  N N 7   
A1BFU C2   C  N N 8   
A1BFU C3   C  N N 9   
A1BFU N2   N  N N 10  
A1BFU O1   O  N N 11  
A1BFU O2   O  N N 12  
A1BFU O3   O  N N 13  
A1BFU S1   S  N N 14  
A1BFU H7   H  N N 15  
A1BFU H8   H  N N 16  
A1BFU H9   H  N N 17  
A1BFU H10  H  N N 18  
A1BFU H12  H  N N 19  
A1BFU H11  H  N N 20  
A1BFU H13  H  N N 21  
A1BFU H14  H  N N 22  
A1BFU H15  H  N N 23  
A1BFU H16  H  N N 24  
A1BFU H1   H  N N 25  
A1BFU H3   H  N N 26  
A1BFU H2   H  N N 27  
A1BFU H4   H  N N 28  
A1BFU H5   H  N N 29  
A1BFU H6   H  N N 30  
ALA   N    N  N N 31  
ALA   CA   C  N S 32  
ALA   C    C  N N 33  
ALA   O    O  N N 34  
ALA   CB   C  N N 35  
ALA   OXT  O  N N 36  
ALA   H    H  N N 37  
ALA   H2   H  N N 38  
ALA   HA   H  N N 39  
ALA   HB1  H  N N 40  
ALA   HB2  H  N N 41  
ALA   HB3  H  N N 42  
ALA   HXT  H  N N 43  
ARG   N    N  N N 44  
ARG   CA   C  N S 45  
ARG   C    C  N N 46  
ARG   O    O  N N 47  
ARG   CB   C  N N 48  
ARG   CG   C  N N 49  
ARG   CD   C  N N 50  
ARG   NE   N  N N 51  
ARG   CZ   C  N N 52  
ARG   NH1  N  N N 53  
ARG   NH2  N  N N 54  
ARG   OXT  O  N N 55  
ARG   H    H  N N 56  
ARG   H2   H  N N 57  
ARG   HA   H  N N 58  
ARG   HB2  H  N N 59  
ARG   HB3  H  N N 60  
ARG   HG2  H  N N 61  
ARG   HG3  H  N N 62  
ARG   HD2  H  N N 63  
ARG   HD3  H  N N 64  
ARG   HE   H  N N 65  
ARG   HH11 H  N N 66  
ARG   HH12 H  N N 67  
ARG   HH21 H  N N 68  
ARG   HH22 H  N N 69  
ARG   HXT  H  N N 70  
ASN   N    N  N N 71  
ASN   CA   C  N S 72  
ASN   C    C  N N 73  
ASN   O    O  N N 74  
ASN   CB   C  N N 75  
ASN   CG   C  N N 76  
ASN   OD1  O  N N 77  
ASN   ND2  N  N N 78  
ASN   OXT  O  N N 79  
ASN   H    H  N N 80  
ASN   H2   H  N N 81  
ASN   HA   H  N N 82  
ASN   HB2  H  N N 83  
ASN   HB3  H  N N 84  
ASN   HD21 H  N N 85  
ASN   HD22 H  N N 86  
ASN   HXT  H  N N 87  
ASP   N    N  N N 88  
ASP   CA   C  N S 89  
ASP   C    C  N N 90  
ASP   O    O  N N 91  
ASP   CB   C  N N 92  
ASP   CG   C  N N 93  
ASP   OD1  O  N N 94  
ASP   OD2  O  N N 95  
ASP   OXT  O  N N 96  
ASP   H    H  N N 97  
ASP   H2   H  N N 98  
ASP   HA   H  N N 99  
ASP   HB2  H  N N 100 
ASP   HB3  H  N N 101 
ASP   HD2  H  N N 102 
ASP   HXT  H  N N 103 
CL    CL   CL N N 104 
CYS   N    N  N N 105 
CYS   CA   C  N R 106 
CYS   C    C  N N 107 
CYS   O    O  N N 108 
CYS   CB   C  N N 109 
CYS   SG   S  N N 110 
CYS   OXT  O  N N 111 
CYS   H    H  N N 112 
CYS   H2   H  N N 113 
CYS   HA   H  N N 114 
CYS   HB2  H  N N 115 
CYS   HB3  H  N N 116 
CYS   HG   H  N N 117 
CYS   HXT  H  N N 118 
DMS   S    S  N N 119 
DMS   O    O  N N 120 
DMS   C1   C  N N 121 
DMS   C2   C  N N 122 
DMS   H11  H  N N 123 
DMS   H12  H  N N 124 
DMS   H13  H  N N 125 
DMS   H21  H  N N 126 
DMS   H22  H  N N 127 
DMS   H23  H  N N 128 
GLN   N    N  N N 129 
GLN   CA   C  N S 130 
GLN   C    C  N N 131 
GLN   O    O  N N 132 
GLN   CB   C  N N 133 
GLN   CG   C  N N 134 
GLN   CD   C  N N 135 
GLN   OE1  O  N N 136 
GLN   NE2  N  N N 137 
GLN   OXT  O  N N 138 
GLN   H    H  N N 139 
GLN   H2   H  N N 140 
GLN   HA   H  N N 141 
GLN   HB2  H  N N 142 
GLN   HB3  H  N N 143 
GLN   HG2  H  N N 144 
GLN   HG3  H  N N 145 
GLN   HE21 H  N N 146 
GLN   HE22 H  N N 147 
GLN   HXT  H  N N 148 
GLU   N    N  N N 149 
GLU   CA   C  N S 150 
GLU   C    C  N N 151 
GLU   O    O  N N 152 
GLU   CB   C  N N 153 
GLU   CG   C  N N 154 
GLU   CD   C  N N 155 
GLU   OE1  O  N N 156 
GLU   OE2  O  N N 157 
GLU   OXT  O  N N 158 
GLU   H    H  N N 159 
GLU   H2   H  N N 160 
GLU   HA   H  N N 161 
GLU   HB2  H  N N 162 
GLU   HB3  H  N N 163 
GLU   HG2  H  N N 164 
GLU   HG3  H  N N 165 
GLU   HE2  H  N N 166 
GLU   HXT  H  N N 167 
GLY   N    N  N N 168 
GLY   CA   C  N N 169 
GLY   C    C  N N 170 
GLY   O    O  N N 171 
GLY   OXT  O  N N 172 
GLY   H    H  N N 173 
GLY   H2   H  N N 174 
GLY   HA2  H  N N 175 
GLY   HA3  H  N N 176 
GLY   HXT  H  N N 177 
HIS   N    N  N N 178 
HIS   CA   C  N S 179 
HIS   C    C  N N 180 
HIS   O    O  N N 181 
HIS   CB   C  N N 182 
HIS   CG   C  Y N 183 
HIS   ND1  N  Y N 184 
HIS   CD2  C  Y N 185 
HIS   CE1  C  Y N 186 
HIS   NE2  N  Y N 187 
HIS   OXT  O  N N 188 
HIS   H    H  N N 189 
HIS   H2   H  N N 190 
HIS   HA   H  N N 191 
HIS   HB2  H  N N 192 
HIS   HB3  H  N N 193 
HIS   HD1  H  N N 194 
HIS   HD2  H  N N 195 
HIS   HE1  H  N N 196 
HIS   HE2  H  N N 197 
HIS   HXT  H  N N 198 
HOH   O    O  N N 199 
HOH   H1   H  N N 200 
HOH   H2   H  N N 201 
ILE   N    N  N N 202 
ILE   CA   C  N S 203 
ILE   C    C  N N 204 
ILE   O    O  N N 205 
ILE   CB   C  N S 206 
ILE   CG1  C  N N 207 
ILE   CG2  C  N N 208 
ILE   CD1  C  N N 209 
ILE   OXT  O  N N 210 
ILE   H    H  N N 211 
ILE   H2   H  N N 212 
ILE   HA   H  N N 213 
ILE   HB   H  N N 214 
ILE   HG12 H  N N 215 
ILE   HG13 H  N N 216 
ILE   HG21 H  N N 217 
ILE   HG22 H  N N 218 
ILE   HG23 H  N N 219 
ILE   HD11 H  N N 220 
ILE   HD12 H  N N 221 
ILE   HD13 H  N N 222 
ILE   HXT  H  N N 223 
LEU   N    N  N N 224 
LEU   CA   C  N S 225 
LEU   C    C  N N 226 
LEU   O    O  N N 227 
LEU   CB   C  N N 228 
LEU   CG   C  N N 229 
LEU   CD1  C  N N 230 
LEU   CD2  C  N N 231 
LEU   OXT  O  N N 232 
LEU   H    H  N N 233 
LEU   H2   H  N N 234 
LEU   HA   H  N N 235 
LEU   HB2  H  N N 236 
LEU   HB3  H  N N 237 
LEU   HG   H  N N 238 
LEU   HD11 H  N N 239 
LEU   HD12 H  N N 240 
LEU   HD13 H  N N 241 
LEU   HD21 H  N N 242 
LEU   HD22 H  N N 243 
LEU   HD23 H  N N 244 
LEU   HXT  H  N N 245 
LYS   N    N  N N 246 
LYS   CA   C  N S 247 
LYS   C    C  N N 248 
LYS   O    O  N N 249 
LYS   CB   C  N N 250 
LYS   CG   C  N N 251 
LYS   CD   C  N N 252 
LYS   CE   C  N N 253 
LYS   NZ   N  N N 254 
LYS   OXT  O  N N 255 
LYS   H    H  N N 256 
LYS   H2   H  N N 257 
LYS   HA   H  N N 258 
LYS   HB2  H  N N 259 
LYS   HB3  H  N N 260 
LYS   HG2  H  N N 261 
LYS   HG3  H  N N 262 
LYS   HD2  H  N N 263 
LYS   HD3  H  N N 264 
LYS   HE2  H  N N 265 
LYS   HE3  H  N N 266 
LYS   HZ1  H  N N 267 
LYS   HZ2  H  N N 268 
LYS   HZ3  H  N N 269 
LYS   HXT  H  N N 270 
MES   O1   O  N N 271 
MES   C2   C  N N 272 
MES   C3   C  N N 273 
MES   N4   N  N N 274 
MES   C5   C  N N 275 
MES   C6   C  N N 276 
MES   C7   C  N N 277 
MES   C8   C  N N 278 
MES   S    S  N N 279 
MES   O1S  O  N N 280 
MES   O2S  O  N N 281 
MES   O3S  O  N N 282 
MES   H21  H  N N 283 
MES   H22  H  N N 284 
MES   H31  H  N N 285 
MES   H32  H  N N 286 
MES   HN4  H  N N 287 
MES   H51  H  N N 288 
MES   H52  H  N N 289 
MES   H61  H  N N 290 
MES   H62  H  N N 291 
MES   H71  H  N N 292 
MES   H72  H  N N 293 
MES   H81  H  N N 294 
MES   H82  H  N N 295 
MET   N    N  N N 296 
MET   CA   C  N S 297 
MET   C    C  N N 298 
MET   O    O  N N 299 
MET   CB   C  N N 300 
MET   CG   C  N N 301 
MET   SD   S  N N 302 
MET   CE   C  N N 303 
MET   OXT  O  N N 304 
MET   H    H  N N 305 
MET   H2   H  N N 306 
MET   HA   H  N N 307 
MET   HB2  H  N N 308 
MET   HB3  H  N N 309 
MET   HG2  H  N N 310 
MET   HG3  H  N N 311 
MET   HE1  H  N N 312 
MET   HE2  H  N N 313 
MET   HE3  H  N N 314 
MET   HXT  H  N N 315 
PEG   C1   C  N N 316 
PEG   O1   O  N N 317 
PEG   C2   C  N N 318 
PEG   O2   O  N N 319 
PEG   C3   C  N N 320 
PEG   C4   C  N N 321 
PEG   O4   O  N N 322 
PEG   H11  H  N N 323 
PEG   H12  H  N N 324 
PEG   HO1  H  N N 325 
PEG   H21  H  N N 326 
PEG   H22  H  N N 327 
PEG   H31  H  N N 328 
PEG   H32  H  N N 329 
PEG   H41  H  N N 330 
PEG   H42  H  N N 331 
PEG   HO4  H  N N 332 
PHE   N    N  N N 333 
PHE   CA   C  N S 334 
PHE   C    C  N N 335 
PHE   O    O  N N 336 
PHE   CB   C  N N 337 
PHE   CG   C  Y N 338 
PHE   CD1  C  Y N 339 
PHE   CD2  C  Y N 340 
PHE   CE1  C  Y N 341 
PHE   CE2  C  Y N 342 
PHE   CZ   C  Y N 343 
PHE   OXT  O  N N 344 
PHE   H    H  N N 345 
PHE   H2   H  N N 346 
PHE   HA   H  N N 347 
PHE   HB2  H  N N 348 
PHE   HB3  H  N N 349 
PHE   HD1  H  N N 350 
PHE   HD2  H  N N 351 
PHE   HE1  H  N N 352 
PHE   HE2  H  N N 353 
PHE   HZ   H  N N 354 
PHE   HXT  H  N N 355 
PO4   P    P  N N 356 
PO4   O1   O  N N 357 
PO4   O2   O  N N 358 
PO4   O3   O  N N 359 
PO4   O4   O  N N 360 
PRO   N    N  N N 361 
PRO   CA   C  N S 362 
PRO   C    C  N N 363 
PRO   O    O  N N 364 
PRO   CB   C  N N 365 
PRO   CG   C  N N 366 
PRO   CD   C  N N 367 
PRO   OXT  O  N N 368 
PRO   H    H  N N 369 
PRO   HA   H  N N 370 
PRO   HB2  H  N N 371 
PRO   HB3  H  N N 372 
PRO   HG2  H  N N 373 
PRO   HG3  H  N N 374 
PRO   HD2  H  N N 375 
PRO   HD3  H  N N 376 
PRO   HXT  H  N N 377 
SER   N    N  N N 378 
SER   CA   C  N S 379 
SER   C    C  N N 380 
SER   O    O  N N 381 
SER   CB   C  N N 382 
SER   OG   O  N N 383 
SER   OXT  O  N N 384 
SER   H    H  N N 385 
SER   H2   H  N N 386 
SER   HA   H  N N 387 
SER   HB2  H  N N 388 
SER   HB3  H  N N 389 
SER   HG   H  N N 390 
SER   HXT  H  N N 391 
THR   N    N  N N 392 
THR   CA   C  N S 393 
THR   C    C  N N 394 
THR   O    O  N N 395 
THR   CB   C  N R 396 
THR   OG1  O  N N 397 
THR   CG2  C  N N 398 
THR   OXT  O  N N 399 
THR   H    H  N N 400 
THR   H2   H  N N 401 
THR   HA   H  N N 402 
THR   HB   H  N N 403 
THR   HG1  H  N N 404 
THR   HG21 H  N N 405 
THR   HG22 H  N N 406 
THR   HG23 H  N N 407 
THR   HXT  H  N N 408 
TRP   N    N  N N 409 
TRP   CA   C  N S 410 
TRP   C    C  N N 411 
TRP   O    O  N N 412 
TRP   CB   C  N N 413 
TRP   CG   C  Y N 414 
TRP   CD1  C  Y N 415 
TRP   CD2  C  Y N 416 
TRP   NE1  N  Y N 417 
TRP   CE2  C  Y N 418 
TRP   CE3  C  Y N 419 
TRP   CZ2  C  Y N 420 
TRP   CZ3  C  Y N 421 
TRP   CH2  C  Y N 422 
TRP   OXT  O  N N 423 
TRP   H    H  N N 424 
TRP   H2   H  N N 425 
TRP   HA   H  N N 426 
TRP   HB2  H  N N 427 
TRP   HB3  H  N N 428 
TRP   HD1  H  N N 429 
TRP   HE1  H  N N 430 
TRP   HE3  H  N N 431 
TRP   HZ2  H  N N 432 
TRP   HZ3  H  N N 433 
TRP   HH2  H  N N 434 
TRP   HXT  H  N N 435 
TYR   N    N  N N 436 
TYR   CA   C  N S 437 
TYR   C    C  N N 438 
TYR   O    O  N N 439 
TYR   CB   C  N N 440 
TYR   CG   C  Y N 441 
TYR   CD1  C  Y N 442 
TYR   CD2  C  Y N 443 
TYR   CE1  C  Y N 444 
TYR   CE2  C  Y N 445 
TYR   CZ   C  Y N 446 
TYR   OH   O  N N 447 
TYR   OXT  O  N N 448 
TYR   H    H  N N 449 
TYR   H2   H  N N 450 
TYR   HA   H  N N 451 
TYR   HB2  H  N N 452 
TYR   HB3  H  N N 453 
TYR   HD1  H  N N 454 
TYR   HD2  H  N N 455 
TYR   HE1  H  N N 456 
TYR   HE2  H  N N 457 
TYR   HH   H  N N 458 
TYR   HXT  H  N N 459 
VAL   N    N  N N 460 
VAL   CA   C  N S 461 
VAL   C    C  N N 462 
VAL   O    O  N N 463 
VAL   CB   C  N N 464 
VAL   CG1  C  N N 465 
VAL   CG2  C  N N 466 
VAL   OXT  O  N N 467 
VAL   H    H  N N 468 
VAL   H2   H  N N 469 
VAL   HA   H  N N 470 
VAL   HB   H  N N 471 
VAL   HG11 H  N N 472 
VAL   HG12 H  N N 473 
VAL   HG13 H  N N 474 
VAL   HG21 H  N N 475 
VAL   HG22 H  N N 476 
VAL   HG23 H  N N 477 
VAL   HXT  H  N N 478 
ZN    ZN   ZN N N 479 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1BFU C1  O1   sing N N 1   
A1BFU O1  C2   sing N N 2   
A1BFU C2  C3   sing N N 3   
A1BFU C3  N1   sing N N 4   
A1BFU N1  C4   sing N N 5   
A1BFU N1  S1   sing N N 6   
A1BFU S1  O2   doub N N 7   
A1BFU S1  O3   doub N N 8   
A1BFU S1  N2   sing N N 9   
A1BFU N2  C5   sing N N 10  
A1BFU C5  C6   sing N N 11  
A1BFU C6  C7   sing N N 12  
A1BFU C7  C8   sing N N 13  
A1BFU C2  C4   sing N N 14  
A1BFU N2  C8   sing N N 15  
A1BFU C4  H7   sing N N 16  
A1BFU C4  H8   sing N N 17  
A1BFU C5  H9   sing N N 18  
A1BFU C5  H10  sing N N 19  
A1BFU C6  H12  sing N N 20  
A1BFU C6  H11  sing N N 21  
A1BFU C7  H13  sing N N 22  
A1BFU C7  H14  sing N N 23  
A1BFU C8  H15  sing N N 24  
A1BFU C8  H16  sing N N 25  
A1BFU C1  H1   sing N N 26  
A1BFU C1  H3   sing N N 27  
A1BFU C1  H2   sing N N 28  
A1BFU C2  H4   sing N N 29  
A1BFU C3  H5   sing N N 30  
A1BFU C3  H6   sing N N 31  
ALA   N   CA   sing N N 32  
ALA   N   H    sing N N 33  
ALA   N   H2   sing N N 34  
ALA   CA  C    sing N N 35  
ALA   CA  CB   sing N N 36  
ALA   CA  HA   sing N N 37  
ALA   C   O    doub N N 38  
ALA   C   OXT  sing N N 39  
ALA   CB  HB1  sing N N 40  
ALA   CB  HB2  sing N N 41  
ALA   CB  HB3  sing N N 42  
ALA   OXT HXT  sing N N 43  
ARG   N   CA   sing N N 44  
ARG   N   H    sing N N 45  
ARG   N   H2   sing N N 46  
ARG   CA  C    sing N N 47  
ARG   CA  CB   sing N N 48  
ARG   CA  HA   sing N N 49  
ARG   C   O    doub N N 50  
ARG   C   OXT  sing N N 51  
ARG   CB  CG   sing N N 52  
ARG   CB  HB2  sing N N 53  
ARG   CB  HB3  sing N N 54  
ARG   CG  CD   sing N N 55  
ARG   CG  HG2  sing N N 56  
ARG   CG  HG3  sing N N 57  
ARG   CD  NE   sing N N 58  
ARG   CD  HD2  sing N N 59  
ARG   CD  HD3  sing N N 60  
ARG   NE  CZ   sing N N 61  
ARG   NE  HE   sing N N 62  
ARG   CZ  NH1  sing N N 63  
ARG   CZ  NH2  doub N N 64  
ARG   NH1 HH11 sing N N 65  
ARG   NH1 HH12 sing N N 66  
ARG   NH2 HH21 sing N N 67  
ARG   NH2 HH22 sing N N 68  
ARG   OXT HXT  sing N N 69  
ASN   N   CA   sing N N 70  
ASN   N   H    sing N N 71  
ASN   N   H2   sing N N 72  
ASN   CA  C    sing N N 73  
ASN   CA  CB   sing N N 74  
ASN   CA  HA   sing N N 75  
ASN   C   O    doub N N 76  
ASN   C   OXT  sing N N 77  
ASN   CB  CG   sing N N 78  
ASN   CB  HB2  sing N N 79  
ASN   CB  HB3  sing N N 80  
ASN   CG  OD1  doub N N 81  
ASN   CG  ND2  sing N N 82  
ASN   ND2 HD21 sing N N 83  
ASN   ND2 HD22 sing N N 84  
ASN   OXT HXT  sing N N 85  
ASP   N   CA   sing N N 86  
ASP   N   H    sing N N 87  
ASP   N   H2   sing N N 88  
ASP   CA  C    sing N N 89  
ASP   CA  CB   sing N N 90  
ASP   CA  HA   sing N N 91  
ASP   C   O    doub N N 92  
ASP   C   OXT  sing N N 93  
ASP   CB  CG   sing N N 94  
ASP   CB  HB2  sing N N 95  
ASP   CB  HB3  sing N N 96  
ASP   CG  OD1  doub N N 97  
ASP   CG  OD2  sing N N 98  
ASP   OD2 HD2  sing N N 99  
ASP   OXT HXT  sing N N 100 
CYS   N   CA   sing N N 101 
CYS   N   H    sing N N 102 
CYS   N   H2   sing N N 103 
CYS   CA  C    sing N N 104 
CYS   CA  CB   sing N N 105 
CYS   CA  HA   sing N N 106 
CYS   C   O    doub N N 107 
CYS   C   OXT  sing N N 108 
CYS   CB  SG   sing N N 109 
CYS   CB  HB2  sing N N 110 
CYS   CB  HB3  sing N N 111 
CYS   SG  HG   sing N N 112 
CYS   OXT HXT  sing N N 113 
DMS   S   O    doub N N 114 
DMS   S   C1   sing N N 115 
DMS   S   C2   sing N N 116 
DMS   C1  H11  sing N N 117 
DMS   C1  H12  sing N N 118 
DMS   C1  H13  sing N N 119 
DMS   C2  H21  sing N N 120 
DMS   C2  H22  sing N N 121 
DMS   C2  H23  sing N N 122 
GLN   N   CA   sing N N 123 
GLN   N   H    sing N N 124 
GLN   N   H2   sing N N 125 
GLN   CA  C    sing N N 126 
GLN   CA  CB   sing N N 127 
GLN   CA  HA   sing N N 128 
GLN   C   O    doub N N 129 
GLN   C   OXT  sing N N 130 
GLN   CB  CG   sing N N 131 
GLN   CB  HB2  sing N N 132 
GLN   CB  HB3  sing N N 133 
GLN   CG  CD   sing N N 134 
GLN   CG  HG2  sing N N 135 
GLN   CG  HG3  sing N N 136 
GLN   CD  OE1  doub N N 137 
GLN   CD  NE2  sing N N 138 
GLN   NE2 HE21 sing N N 139 
GLN   NE2 HE22 sing N N 140 
GLN   OXT HXT  sing N N 141 
GLU   N   CA   sing N N 142 
GLU   N   H    sing N N 143 
GLU   N   H2   sing N N 144 
GLU   CA  C    sing N N 145 
GLU   CA  CB   sing N N 146 
GLU   CA  HA   sing N N 147 
GLU   C   O    doub N N 148 
GLU   C   OXT  sing N N 149 
GLU   CB  CG   sing N N 150 
GLU   CB  HB2  sing N N 151 
GLU   CB  HB3  sing N N 152 
GLU   CG  CD   sing N N 153 
GLU   CG  HG2  sing N N 154 
GLU   CG  HG3  sing N N 155 
GLU   CD  OE1  doub N N 156 
GLU   CD  OE2  sing N N 157 
GLU   OE2 HE2  sing N N 158 
GLU   OXT HXT  sing N N 159 
GLY   N   CA   sing N N 160 
GLY   N   H    sing N N 161 
GLY   N   H2   sing N N 162 
GLY   CA  C    sing N N 163 
GLY   CA  HA2  sing N N 164 
GLY   CA  HA3  sing N N 165 
GLY   C   O    doub N N 166 
GLY   C   OXT  sing N N 167 
GLY   OXT HXT  sing N N 168 
HIS   N   CA   sing N N 169 
HIS   N   H    sing N N 170 
HIS   N   H2   sing N N 171 
HIS   CA  C    sing N N 172 
HIS   CA  CB   sing N N 173 
HIS   CA  HA   sing N N 174 
HIS   C   O    doub N N 175 
HIS   C   OXT  sing N N 176 
HIS   CB  CG   sing N N 177 
HIS   CB  HB2  sing N N 178 
HIS   CB  HB3  sing N N 179 
HIS   CG  ND1  sing Y N 180 
HIS   CG  CD2  doub Y N 181 
HIS   ND1 CE1  doub Y N 182 
HIS   ND1 HD1  sing N N 183 
HIS   CD2 NE2  sing Y N 184 
HIS   CD2 HD2  sing N N 185 
HIS   CE1 NE2  sing Y N 186 
HIS   CE1 HE1  sing N N 187 
HIS   NE2 HE2  sing N N 188 
HIS   OXT HXT  sing N N 189 
HOH   O   H1   sing N N 190 
HOH   O   H2   sing N N 191 
ILE   N   CA   sing N N 192 
ILE   N   H    sing N N 193 
ILE   N   H2   sing N N 194 
ILE   CA  C    sing N N 195 
ILE   CA  CB   sing N N 196 
ILE   CA  HA   sing N N 197 
ILE   C   O    doub N N 198 
ILE   C   OXT  sing N N 199 
ILE   CB  CG1  sing N N 200 
ILE   CB  CG2  sing N N 201 
ILE   CB  HB   sing N N 202 
ILE   CG1 CD1  sing N N 203 
ILE   CG1 HG12 sing N N 204 
ILE   CG1 HG13 sing N N 205 
ILE   CG2 HG21 sing N N 206 
ILE   CG2 HG22 sing N N 207 
ILE   CG2 HG23 sing N N 208 
ILE   CD1 HD11 sing N N 209 
ILE   CD1 HD12 sing N N 210 
ILE   CD1 HD13 sing N N 211 
ILE   OXT HXT  sing N N 212 
LEU   N   CA   sing N N 213 
LEU   N   H    sing N N 214 
LEU   N   H2   sing N N 215 
LEU   CA  C    sing N N 216 
LEU   CA  CB   sing N N 217 
LEU   CA  HA   sing N N 218 
LEU   C   O    doub N N 219 
LEU   C   OXT  sing N N 220 
LEU   CB  CG   sing N N 221 
LEU   CB  HB2  sing N N 222 
LEU   CB  HB3  sing N N 223 
LEU   CG  CD1  sing N N 224 
LEU   CG  CD2  sing N N 225 
LEU   CG  HG   sing N N 226 
LEU   CD1 HD11 sing N N 227 
LEU   CD1 HD12 sing N N 228 
LEU   CD1 HD13 sing N N 229 
LEU   CD2 HD21 sing N N 230 
LEU   CD2 HD22 sing N N 231 
LEU   CD2 HD23 sing N N 232 
LEU   OXT HXT  sing N N 233 
LYS   N   CA   sing N N 234 
LYS   N   H    sing N N 235 
LYS   N   H2   sing N N 236 
LYS   CA  C    sing N N 237 
LYS   CA  CB   sing N N 238 
LYS   CA  HA   sing N N 239 
LYS   C   O    doub N N 240 
LYS   C   OXT  sing N N 241 
LYS   CB  CG   sing N N 242 
LYS   CB  HB2  sing N N 243 
LYS   CB  HB3  sing N N 244 
LYS   CG  CD   sing N N 245 
LYS   CG  HG2  sing N N 246 
LYS   CG  HG3  sing N N 247 
LYS   CD  CE   sing N N 248 
LYS   CD  HD2  sing N N 249 
LYS   CD  HD3  sing N N 250 
LYS   CE  NZ   sing N N 251 
LYS   CE  HE2  sing N N 252 
LYS   CE  HE3  sing N N 253 
LYS   NZ  HZ1  sing N N 254 
LYS   NZ  HZ2  sing N N 255 
LYS   NZ  HZ3  sing N N 256 
LYS   OXT HXT  sing N N 257 
MES   O1  C2   sing N N 258 
MES   O1  C6   sing N N 259 
MES   C2  C3   sing N N 260 
MES   C2  H21  sing N N 261 
MES   C2  H22  sing N N 262 
MES   C3  N4   sing N N 263 
MES   C3  H31  sing N N 264 
MES   C3  H32  sing N N 265 
MES   N4  C5   sing N N 266 
MES   N4  C7   sing N N 267 
MES   N4  HN4  sing N N 268 
MES   C5  C6   sing N N 269 
MES   C5  H51  sing N N 270 
MES   C5  H52  sing N N 271 
MES   C6  H61  sing N N 272 
MES   C6  H62  sing N N 273 
MES   C7  C8   sing N N 274 
MES   C7  H71  sing N N 275 
MES   C7  H72  sing N N 276 
MES   C8  S    sing N N 277 
MES   C8  H81  sing N N 278 
MES   C8  H82  sing N N 279 
MES   S   O1S  doub N N 280 
MES   S   O2S  doub N N 281 
MES   S   O3S  sing N N 282 
MET   N   CA   sing N N 283 
MET   N   H    sing N N 284 
MET   N   H2   sing N N 285 
MET   CA  C    sing N N 286 
MET   CA  CB   sing N N 287 
MET   CA  HA   sing N N 288 
MET   C   O    doub N N 289 
MET   C   OXT  sing N N 290 
MET   CB  CG   sing N N 291 
MET   CB  HB2  sing N N 292 
MET   CB  HB3  sing N N 293 
MET   CG  SD   sing N N 294 
MET   CG  HG2  sing N N 295 
MET   CG  HG3  sing N N 296 
MET   SD  CE   sing N N 297 
MET   CE  HE1  sing N N 298 
MET   CE  HE2  sing N N 299 
MET   CE  HE3  sing N N 300 
MET   OXT HXT  sing N N 301 
PEG   C1  O1   sing N N 302 
PEG   C1  C2   sing N N 303 
PEG   C1  H11  sing N N 304 
PEG   C1  H12  sing N N 305 
PEG   O1  HO1  sing N N 306 
PEG   C2  O2   sing N N 307 
PEG   C2  H21  sing N N 308 
PEG   C2  H22  sing N N 309 
PEG   O2  C3   sing N N 310 
PEG   C3  C4   sing N N 311 
PEG   C3  H31  sing N N 312 
PEG   C3  H32  sing N N 313 
PEG   C4  O4   sing N N 314 
PEG   C4  H41  sing N N 315 
PEG   C4  H42  sing N N 316 
PEG   O4  HO4  sing N N 317 
PHE   N   CA   sing N N 318 
PHE   N   H    sing N N 319 
PHE   N   H2   sing N N 320 
PHE   CA  C    sing N N 321 
PHE   CA  CB   sing N N 322 
PHE   CA  HA   sing N N 323 
PHE   C   O    doub N N 324 
PHE   C   OXT  sing N N 325 
PHE   CB  CG   sing N N 326 
PHE   CB  HB2  sing N N 327 
PHE   CB  HB3  sing N N 328 
PHE   CG  CD1  doub Y N 329 
PHE   CG  CD2  sing Y N 330 
PHE   CD1 CE1  sing Y N 331 
PHE   CD1 HD1  sing N N 332 
PHE   CD2 CE2  doub Y N 333 
PHE   CD2 HD2  sing N N 334 
PHE   CE1 CZ   doub Y N 335 
PHE   CE1 HE1  sing N N 336 
PHE   CE2 CZ   sing Y N 337 
PHE   CE2 HE2  sing N N 338 
PHE   CZ  HZ   sing N N 339 
PHE   OXT HXT  sing N N 340 
PO4   P   O1   doub N N 341 
PO4   P   O2   sing N N 342 
PO4   P   O3   sing N N 343 
PO4   P   O4   sing N N 344 
PRO   N   CA   sing N N 345 
PRO   N   CD   sing N N 346 
PRO   N   H    sing N N 347 
PRO   CA  C    sing N N 348 
PRO   CA  CB   sing N N 349 
PRO   CA  HA   sing N N 350 
PRO   C   O    doub N N 351 
PRO   C   OXT  sing N N 352 
PRO   CB  CG   sing N N 353 
PRO   CB  HB2  sing N N 354 
PRO   CB  HB3  sing N N 355 
PRO   CG  CD   sing N N 356 
PRO   CG  HG2  sing N N 357 
PRO   CG  HG3  sing N N 358 
PRO   CD  HD2  sing N N 359 
PRO   CD  HD3  sing N N 360 
PRO   OXT HXT  sing N N 361 
SER   N   CA   sing N N 362 
SER   N   H    sing N N 363 
SER   N   H2   sing N N 364 
SER   CA  C    sing N N 365 
SER   CA  CB   sing N N 366 
SER   CA  HA   sing N N 367 
SER   C   O    doub N N 368 
SER   C   OXT  sing N N 369 
SER   CB  OG   sing N N 370 
SER   CB  HB2  sing N N 371 
SER   CB  HB3  sing N N 372 
SER   OG  HG   sing N N 373 
SER   OXT HXT  sing N N 374 
THR   N   CA   sing N N 375 
THR   N   H    sing N N 376 
THR   N   H2   sing N N 377 
THR   CA  C    sing N N 378 
THR   CA  CB   sing N N 379 
THR   CA  HA   sing N N 380 
THR   C   O    doub N N 381 
THR   C   OXT  sing N N 382 
THR   CB  OG1  sing N N 383 
THR   CB  CG2  sing N N 384 
THR   CB  HB   sing N N 385 
THR   OG1 HG1  sing N N 386 
THR   CG2 HG21 sing N N 387 
THR   CG2 HG22 sing N N 388 
THR   CG2 HG23 sing N N 389 
THR   OXT HXT  sing N N 390 
TRP   N   CA   sing N N 391 
TRP   N   H    sing N N 392 
TRP   N   H2   sing N N 393 
TRP   CA  C    sing N N 394 
TRP   CA  CB   sing N N 395 
TRP   CA  HA   sing N N 396 
TRP   C   O    doub N N 397 
TRP   C   OXT  sing N N 398 
TRP   CB  CG   sing N N 399 
TRP   CB  HB2  sing N N 400 
TRP   CB  HB3  sing N N 401 
TRP   CG  CD1  doub Y N 402 
TRP   CG  CD2  sing Y N 403 
TRP   CD1 NE1  sing Y N 404 
TRP   CD1 HD1  sing N N 405 
TRP   CD2 CE2  doub Y N 406 
TRP   CD2 CE3  sing Y N 407 
TRP   NE1 CE2  sing Y N 408 
TRP   NE1 HE1  sing N N 409 
TRP   CE2 CZ2  sing Y N 410 
TRP   CE3 CZ3  doub Y N 411 
TRP   CE3 HE3  sing N N 412 
TRP   CZ2 CH2  doub Y N 413 
TRP   CZ2 HZ2  sing N N 414 
TRP   CZ3 CH2  sing Y N 415 
TRP   CZ3 HZ3  sing N N 416 
TRP   CH2 HH2  sing N N 417 
TRP   OXT HXT  sing N N 418 
TYR   N   CA   sing N N 419 
TYR   N   H    sing N N 420 
TYR   N   H2   sing N N 421 
TYR   CA  C    sing N N 422 
TYR   CA  CB   sing N N 423 
TYR   CA  HA   sing N N 424 
TYR   C   O    doub N N 425 
TYR   C   OXT  sing N N 426 
TYR   CB  CG   sing N N 427 
TYR   CB  HB2  sing N N 428 
TYR   CB  HB3  sing N N 429 
TYR   CG  CD1  doub Y N 430 
TYR   CG  CD2  sing Y N 431 
TYR   CD1 CE1  sing Y N 432 
TYR   CD1 HD1  sing N N 433 
TYR   CD2 CE2  doub Y N 434 
TYR   CD2 HD2  sing N N 435 
TYR   CE1 CZ   doub Y N 436 
TYR   CE1 HE1  sing N N 437 
TYR   CE2 CZ   sing Y N 438 
TYR   CE2 HE2  sing N N 439 
TYR   CZ  OH   sing N N 440 
TYR   OH  HH   sing N N 441 
TYR   OXT HXT  sing N N 442 
VAL   N   CA   sing N N 443 
VAL   N   H    sing N N 444 
VAL   N   H2   sing N N 445 
VAL   CA  C    sing N N 446 
VAL   CA  CB   sing N N 447 
VAL   CA  HA   sing N N 448 
VAL   C   O    doub N N 449 
VAL   C   OXT  sing N N 450 
VAL   CB  CG1  sing N N 451 
VAL   CB  CG2  sing N N 452 
VAL   CB  HB   sing N N 453 
VAL   CG1 HG11 sing N N 454 
VAL   CG1 HG12 sing N N 455 
VAL   CG1 HG13 sing N N 456 
VAL   CG2 HG21 sing N N 457 
VAL   CG2 HG22 sing N N 458 
VAL   CG2 HG23 sing N N 459 
VAL   OXT HXT  sing N N 460 
# 
_pdbx_audit_support.ordinal                1 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)' 
_pdbx_audit_support.grant_number           U19AI171292 
_pdbx_audit_support.country                'United States' 
# 
_pdbx_deposit_group.group_id            G_1002341 
_pdbx_deposit_group.group_description   
'Crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_title         
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_type          'changed state' 
# 
_atom_sites.entry_id                    7I2K 
_atom_sites.fract_transf_matrix[1][1]   0.012154 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.008618 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006761 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
# 
loop_
_atom_type.symbol 
C  
CL 
N  
O  
P  
S  
ZN 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ASN   A 1 10  ? -13.771 -5.450  -12.349 0.50 98.34  ? 273  ASN   A N   1 
ATOM   2    C  CA  . ASN   A 1 10  ? -13.564 -6.575  -11.400 0.50 96.99  ? 273  ASN   A CA  1 
ATOM   3    C  C   . ASN   A 1 10  ? -14.684 -6.578  -10.358 0.50 96.25  ? 273  ASN   A C   1 
ATOM   4    O  O   . ASN   A 1 10  ? -15.664 -7.316  -10.561 0.50 92.62  ? 273  ASN   A O   1 
ATOM   5    C  CB  . ASN   A 1 10  ? -12.187 -6.509  -10.736 0.50 98.74  ? 273  ASN   A CB  1 
ATOM   6    C  CG  . ASN   A 1 10  ? -11.960 -7.614  -9.727  0.50 98.32  ? 273  ASN   A CG  1 
ATOM   7    O  OD1 . ASN   A 1 10  ? -12.653 -8.629  -9.745  0.50 97.45  ? 273  ASN   A OD1 1 
ATOM   8    N  ND2 . ASN   A 1 10  ? -10.988 -7.430  -8.848  0.50 95.90  ? 273  ASN   A ND2 1 
ATOM   9    N  N   . LEU   A 1 11  ? -14.548 -5.778  -9.294  1.00 95.13  ? 274  LEU   A N   1 
ATOM   10   C  CA  . LEU   A 1 11  ? -15.548 -5.813  -8.195  1.00 84.17  ? 274  LEU   A CA  1 
ATOM   11   C  C   . LEU   A 1 11  ? -16.888 -5.292  -8.711  1.00 77.71  ? 274  LEU   A C   1 
ATOM   12   O  O   . LEU   A 1 11  ? -17.915 -5.619  -8.102  1.00 70.89  ? 274  LEU   A O   1 
ATOM   13   C  CB  . LEU   A 1 11  ? -15.022 -5.001  -7.011  1.00 90.31  ? 274  LEU   A CB  1 
ATOM   14   C  CG  . LEU   A 1 11  ? -14.409 -5.831  -5.886  1.00 99.15  ? 274  LEU   A CG  1 
ATOM   15   C  CD1 . LEU   A 1 11  ? -13.619 -4.955  -4.928  1.00 99.93  ? 274  LEU   A CD1 1 
ATOM   16   C  CD2 . LEU   A 1 11  ? -15.483 -6.608  -5.142  1.00 92.75  ? 274  LEU   A CD2 1 
ATOM   17   N  N   . ASP   A 1 12  ? -16.871 -4.535  -9.803  0.50 77.21  ? 275  ASP   A N   1 
ATOM   18   C  CA  . ASP   A 1 12  ? -18.147 -4.080  -10.410 0.50 82.15  ? 275  ASP   A CA  1 
ATOM   19   C  C   . ASP   A 1 12  ? -18.925 -5.302  -10.906 0.50 82.77  ? 275  ASP   A C   1 
ATOM   20   O  O   . ASP   A 1 12  ? -20.166 -5.250  -10.875 0.50 84.14  ? 275  ASP   A O   1 
ATOM   21   C  CB  . ASP   A 1 12  ? -17.889 -3.085  -11.541 0.50 85.43  ? 275  ASP   A CB  1 
ATOM   22   C  CG  . ASP   A 1 12  ? -16.950 -3.620  -12.607 0.50 88.52  ? 275  ASP   A CG  1 
ATOM   23   O  OD1 . ASP   A 1 12  ? -16.251 -4.612  -12.326 0.50 88.08  ? 275  ASP   A OD1 1 
ATOM   24   O  OD2 . ASP   A 1 12  ? -16.931 -3.043  -13.711 0.50 95.79  ? 275  ASP   A OD2 1 
ATOM   25   N  N   . ILE   A 1 13  ? -18.222 -6.356  -11.337 1.00 82.08  ? 276  ILE   A N   1 
ATOM   26   C  CA  . ILE   A 1 13  ? -18.894 -7.554  -11.925 1.00 68.28  ? 276  ILE   A CA  1 
ATOM   27   C  C   . ILE   A 1 13  ? -19.161 -8.595  -10.838 1.00 60.88  ? 276  ILE   A C   1 
ATOM   28   O  O   . ILE   A 1 13  ? -20.116 -9.359  -10.995 1.00 54.72  ? 276  ILE   A O   1 
ATOM   29   C  CB  . ILE   A 1 13  ? -18.031 -8.111  -13.073 1.00 68.83  ? 276  ILE   A CB  1 
ATOM   30   C  CG1 . ILE   A 1 13  ? -17.868 -7.080  -14.193 1.00 64.10  ? 276  ILE   A CG1 1 
ATOM   31   C  CG2 . ILE   A 1 13  ? -18.582 -9.429  -13.590 1.00 62.83  ? 276  ILE   A CG2 1 
ATOM   32   C  CD1 . ILE   A 1 13  ? -16.890 -7.482  -15.266 1.00 62.70  ? 276  ILE   A CD1 1 
ATOM   33   N  N   . ILE   A 1 14  ? -18.381 -8.583  -9.761  1.00 61.30  ? 277  ILE   A N   1 
ATOM   34   C  CA  . ILE   A 1 14  ? -18.512 -9.639  -8.718  1.00 69.08  ? 277  ILE   A CA  1 
ATOM   35   C  C   . ILE   A 1 14  ? -19.125 -9.083  -7.430  1.00 69.93  ? 277  ILE   A C   1 
ATOM   36   O  O   . ILE   A 1 14  ? -19.667 -9.885  -6.659  1.00 70.08  ? 277  ILE   A O   1 
ATOM   37   C  CB  . ILE   A 1 14  ? -17.131 -10.265 -8.458  1.00 74.78  ? 277  ILE   A CB  1 
ATOM   38   C  CG1 . ILE   A 1 14  ? -16.120 -9.229  -7.967  1.00 69.71  ? 277  ILE   A CG1 1 
ATOM   39   C  CG2 . ILE   A 1 14  ? -16.637 -10.992 -9.698  1.00 72.43  ? 277  ILE   A CG2 1 
ATOM   40   C  CD1 . ILE   A 1 14  ? -14.766 -9.809  -7.648  1.00 74.05  ? 277  ILE   A CD1 1 
ATOM   41   N  N   . GLY   A 1 15  ? -19.047 -7.772  -7.205  1.00 83.06  ? 278  GLY   A N   1 
ATOM   42   C  CA  . GLY   A 1 15  ? -19.531 -7.177  -5.940  1.00 84.21  ? 278  GLY   A CA  1 
ATOM   43   C  C   . GLY   A 1 15  ? -20.957 -7.558  -5.584  1.00 76.49  ? 278  GLY   A C   1 
ATOM   44   O  O   . GLY   A 1 15  ? -21.158 -8.085  -4.487  1.00 87.12  ? 278  GLY   A O   1 
ATOM   45   N  N   . LYS   A 1 16  ? -21.912 -7.303  -6.474  1.00 70.63  ? 279  LYS   A N   1 
ATOM   46   C  CA  . LYS   A 1 16  ? -23.337 -7.581  -6.171  1.00 66.24  ? 279  LYS   A CA  1 
ATOM   47   C  C   . LYS   A 1 16  ? -23.459 -9.011  -5.664  1.00 65.71  ? 279  LYS   A C   1 
ATOM   48   O  O   . LYS   A 1 16  ? -24.161 -9.229  -4.669  1.00 57.72  ? 279  LYS   A O   1 
ATOM   49   C  CB  . LYS   A 1 16  ? -24.160 -7.378  -7.443  1.00 72.10  ? 279  LYS   A CB  1 
ATOM   50   C  CG  . LYS   A 1 16  ? -25.666 -7.557  -7.318  1.00 75.49  ? 279  LYS   A CG  1 
ATOM   51   C  CD  . LYS   A 1 16  ? -26.382 -7.245  -8.615  1.00 79.79  ? 279  LYS   A CD  1 
ATOM   52   C  CE  . LYS   A 1 16  ? -27.888 -7.194  -8.480  1.00 86.17  ? 279  LYS   A CE  1 
ATOM   53   N  NZ  . LYS   A 1 16  ? -28.319 -6.117  -7.559  1.00 92.43  ? 279  LYS   A NZ  1 
ATOM   54   N  N   . ARG   A 1 17  ? -22.786 -9.937  -6.341  1.00 68.62  ? 280  ARG   A N   1 
ATOM   55   C  CA  . ARG   A 1 17  ? -22.856 -11.371 -5.970  1.00 67.58  ? 280  ARG   A CA  1 
ATOM   56   C  C   . ARG   A 1 17  ? -22.273 -11.517 -4.573  1.00 66.83  ? 280  ARG   A C   1 
ATOM   57   O  O   . ARG   A 1 17  ? -22.852 -12.280 -3.788  1.00 65.90  ? 280  ARG   A O   1 
ATOM   58   C  CB  . ARG   A 1 17  ? -22.071 -12.249 -6.952  1.00 72.43  ? 280  ARG   A CB  1 
ATOM   59   C  CG  . ARG   A 1 17  ? -22.936 -13.074 -7.893  1.00 69.14  ? 280  ARG   A CG  1 
ATOM   60   C  CD  . ARG   A 1 17  ? -22.127 -13.780 -8.965  1.00 59.11  ? 280  ARG   A CD  1 
ATOM   61   N  NE  . ARG   A 1 17  ? -21.514 -12.820 -9.864  1.00 56.67  ? 280  ARG   A NE  1 
ATOM   62   C  CZ  . ARG   A 1 17  ? -20.662 -13.120 -10.834 1.00 55.06  ? 280  ARG   A CZ  1 
ATOM   63   N  NH1 . ARG   A 1 17  ? -20.273 -14.368 -11.037 1.00 54.20  ? 280  ARG   A NH1 1 
ATOM   64   N  NH2 . ARG   A 1 17  ? -20.184 -12.152 -11.588 1.00 53.63  ? 280  ARG   A NH2 1 
ATOM   65   N  N   . ILE   A 1 18  ? -21.171 -10.798 -4.314  1.00 74.28  ? 281  ILE   A N   1 
ATOM   66   C  CA  . ILE   A 1 18  ? -20.436 -10.771 -3.014  1.00 77.74  ? 281  ILE   A CA  1 
ATOM   67   C  C   . ILE   A 1 18  ? -21.330 -10.070 -1.978  1.00 81.51  ? 281  ILE   A C   1 
ATOM   68   O  O   . ILE   A 1 18  ? -21.630 -10.719 -0.942  1.00 82.83  ? 281  ILE   A O   1 
ATOM   69   C  CB  . ILE   A 1 18  ? -19.041 -10.123 -3.180  1.00 79.26  ? 281  ILE   A CB  1 
ATOM   70   C  CG1 . ILE   A 1 18  ? -18.155 -10.957 -4.102  1.00 82.41  ? 281  ILE   A CG1 1 
ATOM   71   C  CG2 . ILE   A 1 18  ? -18.348 -9.912  -1.843  1.00 81.42  ? 281  ILE   A CG2 1 
ATOM   72   C  CD1 . ILE   A 1 18  ? -16.910 -10.249 -4.541  1.00 85.73  ? 281  ILE   A CD1 1 
ATOM   73   N  N   . GLU   A 1 19  ? -21.791 -8.841  -2.277  1.00 82.35  ? 282  GLU   A N   1 
ATOM   74   C  CA  . GLU   A 1 19  ? -22.683 -8.020  -1.404  1.00 78.53  ? 282  GLU   A CA  1 
ATOM   75   C  C   . GLU   A 1 19  ? -23.878 -8.850  -0.950  1.00 74.99  ? 282  GLU   A C   1 
ATOM   76   O  O   . GLU   A 1 19  ? -24.193 -8.801  0.247   1.00 82.03  ? 282  GLU   A O   1 
ATOM   77   C  CB  . GLU   A 1 19  ? -23.251 -6.804  -2.124  1.00 84.80  ? 282  GLU   A CB  1 
ATOM   78   C  CG  . GLU   A 1 19  ? -22.280 -5.649  -2.240  1.00 94.11  ? 282  GLU   A CG  1 
ATOM   79   C  CD  . GLU   A 1 19  ? -22.741 -4.596  -3.234  1.00 107.28 ? 282  GLU   A CD  1 
ATOM   80   O  OE1 . GLU   A 1 19  ? -23.969 -4.500  -3.472  1.00 113.05 ? 282  GLU   A OE1 1 
ATOM   81   O  OE2 . GLU   A 1 19  ? -21.876 -3.893  -3.792  1.00 118.26 ? 282  GLU   A OE2 1 
ATOM   82   N  N   . LYS   A 1 20  ? -24.512 -9.567  -1.883  1.00 70.64  ? 283  LYS   A N   1 
ATOM   83   C  CA  . LYS   A 1 20  ? -25.713 -10.395 -1.614  1.00 67.52  ? 283  LYS   A CA  1 
ATOM   84   C  C   . LYS   A 1 20  ? -25.371 -11.496 -0.608  1.00 72.47  ? 283  LYS   A C   1 
ATOM   85   O  O   . LYS   A 1 20  ? -26.134 -11.626 0.358   1.00 73.59  ? 283  LYS   A O   1 
ATOM   86   C  CB  . LYS   A 1 20  ? -26.265 -11.020 -2.895  1.00 70.95  ? 283  LYS   A CB  1 
ATOM   87   C  CG  . LYS   A 1 20  ? -27.315 -12.103 -2.671  1.00 68.36  ? 283  LYS   A CG  1 
ATOM   88   C  CD  . LYS   A 1 20  ? -28.331 -12.182 -3.802  1.00 73.30  ? 283  LYS   A CD  1 
ATOM   89   C  CE  . LYS   A 1 20  ? -29.661 -12.779 -3.390  1.00 71.12  ? 283  LYS   A CE  1 
ATOM   90   N  NZ  . LYS   A 1 20  ? -29.583 -14.248 -3.225  1.00 67.84  ? 283  LYS   A NZ  1 
ATOM   91   N  N   . ILE   A 1 21  ? -24.307 -12.276 -0.836  1.00 70.35  ? 284  ILE   A N   1 
ATOM   92   C  CA  . ILE   A 1 21  ? -23.976 -13.446 0.035   1.00 78.29  ? 284  ILE   A CA  1 
ATOM   93   C  C   . ILE   A 1 21  ? -23.683 -12.902 1.439   1.00 79.78  ? 284  ILE   A C   1 
ATOM   94   O  O   . ILE   A 1 21  ? -24.195 -13.486 2.439   1.00 66.12  ? 284  ILE   A O   1 
ATOM   95   C  CB  . ILE   A 1 21  ? -22.787 -14.263 -0.513  1.00 80.98  ? 284  ILE   A CB  1 
ATOM   96   C  CG1 . ILE   A 1 21  ? -23.100 -14.904 -1.866  1.00 78.49  ? 284  ILE   A CG1 1 
ATOM   97   C  CG2 . ILE   A 1 21  ? -22.337 -15.309 0.502   1.00 80.90  ? 284  ILE   A CG2 1 
ATOM   98   C  CD1 . ILE   A 1 21  ? -21.870 -15.190 -2.708  1.00 76.36  ? 284  ILE   A CD1 1 
ATOM   99   N  N   . LYS   A 1 22  ? -22.901 -11.817 1.486   1.00 76.32  ? 285  LYS   A N   1 
ATOM   100  C  CA  . LYS   A 1 22  ? -22.451 -11.121 2.721   1.00 89.05  ? 285  LYS   A CA  1 
ATOM   101  C  C   . LYS   A 1 22  ? -23.644 -10.889 3.648   1.00 82.67  ? 285  LYS   A C   1 
ATOM   102  O  O   . LYS   A 1 22  ? -23.461 -11.011 4.864   1.00 85.05  ? 285  LYS   A O   1 
ATOM   103  C  CB  . LYS   A 1 22  ? -21.769 -9.795  2.368   1.00 100.61 ? 285  LYS   A CB  1 
ATOM   104  C  CG  . LYS   A 1 22  ? -21.381 -8.923  3.555   1.00 111.84 ? 285  LYS   A CG  1 
ATOM   105  C  CD  . LYS   A 1 22  ? -20.497 -7.741  3.193   1.00 116.73 ? 285  LYS   A CD  1 
ATOM   106  C  CE  . LYS   A 1 22  ? -20.345 -6.766  4.343   1.00 121.54 ? 285  LYS   A CE  1 
ATOM   107  N  NZ  . LYS   A 1 22  ? -19.775 -5.471  3.904   1.00 123.68 ? 285  LYS   A NZ  1 
ATOM   108  N  N   . GLN   A 1 23  ? -24.790 -10.530 3.076   1.00 85.67  ? 286  GLN   A N   1 
ATOM   109  C  CA  . GLN   A 1 23  ? -25.977 -10.174 3.895   1.00 85.22  ? 286  GLN   A CA  1 
ATOM   110  C  C   . GLN   A 1 23  ? -26.653 -11.432 4.444   1.00 85.54  ? 286  GLN   A C   1 
ATOM   111  O  O   . GLN   A 1 23  ? -26.840 -11.497 5.667   1.00 106.66 ? 286  GLN   A O   1 
ATOM   112  C  CB  . GLN   A 1 23  ? -26.918 -9.310  3.056   1.00 81.08  ? 286  GLN   A CB  1 
ATOM   113  C  CG  . GLN   A 1 23  ? -26.242 -8.058  2.519   1.00 86.74  ? 286  GLN   A CG  1 
ATOM   114  C  CD  . GLN   A 1 23  ? -27.132 -7.264  1.596   1.00 93.14  ? 286  GLN   A CD  1 
ATOM   115  O  OE1 . GLN   A 1 23  ? -28.318 -7.547  1.449   1.00 97.74  ? 286  GLN   A OE1 1 
ATOM   116  N  NE2 . GLN   A 1 23  ? -26.559 -6.255  0.963   1.00 103.59 ? 286  GLN   A NE2 1 
ATOM   117  N  N   . GLU   A 1 24  ? -27.001 -12.392 3.592   1.00 81.64  ? 287  GLU   A N   1 
ATOM   118  C  CA  . GLU   A 1 24  ? -27.746 -13.569 4.097   1.00 89.96  ? 287  GLU   A CA  1 
ATOM   119  C  C   . GLU   A 1 24  ? -26.970 -14.162 5.271   1.00 101.25 ? 287  GLU   A C   1 
ATOM   120  O  O   . GLU   A 1 24  ? -27.571 -14.928 6.046   1.00 99.83  ? 287  GLU   A O   1 
ATOM   121  C  CB  . GLU   A 1 24  ? -27.919 -14.619 3.002   1.00 98.17  ? 287  GLU   A CB  1 
ATOM   122  C  CG  . GLU   A 1 24  ? -28.881 -14.205 1.905   1.00 106.14 ? 287  GLU   A CG  1 
ATOM   123  C  CD  . GLU   A 1 24  ? -28.252 -13.486 0.724   1.00 108.24 ? 287  GLU   A CD  1 
ATOM   124  O  OE1 . GLU   A 1 24  ? -28.762 -12.414 0.350   1.00 105.67 ? 287  GLU   A OE1 1 
ATOM   125  O  OE2 . GLU   A 1 24  ? -27.264 -14.009 0.173   1.00 97.10  ? 287  GLU   A OE2 1 
ATOM   126  N  N   . HIS   A 1 25  ? -25.683 -13.830 5.381   1.00 109.63 ? 288  HIS   A N   1 
ATOM   127  C  CA  . HIS   A 1 25  ? -24.824 -14.386 6.458   1.00 107.96 ? 288  HIS   A CA  1 
ATOM   128  C  C   . HIS   A 1 25  ? -24.139 -13.239 7.216   1.00 111.05 ? 288  HIS   A C   1 
ATOM   129  O  O   . HIS   A 1 25  ? -23.014 -13.443 7.699   1.00 109.73 ? 288  HIS   A O   1 
ATOM   130  C  CB  . HIS   A 1 25  ? -23.842 -15.391 5.846   1.00 100.50 ? 288  HIS   A CB  1 
ATOM   131  C  CG  . HIS   A 1 25  ? -24.497 -16.431 5.004   1.00 98.65  ? 288  HIS   A CG  1 
ATOM   132  N  ND1 . HIS   A 1 25  ? -25.274 -17.434 5.543   1.00 104.57 ? 288  HIS   A ND1 1 
ATOM   133  C  CD2 . HIS   A 1 25  ? -24.489 -16.633 3.670   1.00 95.65  ? 288  HIS   A CD2 1 
ATOM   134  C  CE1 . HIS   A 1 25  ? -25.720 -18.209 4.576   1.00 98.57  ? 288  HIS   A CE1 1 
ATOM   135  N  NE2 . HIS   A 1 25  ? -25.253 -17.738 3.418   1.00 93.97  ? 288  HIS   A NE2 1 
ATOM   136  N  N   . GLU   A 1 26  ? -24.802 -12.086 7.338   1.00 117.77 ? 289  GLU   A N   1 
ATOM   137  C  CA  . GLU   A 1 26  ? -24.196 -10.901 8.007   1.00 119.33 ? 289  GLU   A CA  1 
ATOM   138  C  C   . GLU   A 1 26  ? -23.900 -11.219 9.481   1.00 121.49 ? 289  GLU   A C   1 
ATOM   139  O  O   . GLU   A 1 26  ? -23.092 -10.494 10.097  1.00 119.44 ? 289  GLU   A O   1 
ATOM   140  C  CB  . GLU   A 1 26  ? -25.132 -9.695  7.895   1.00 111.16 ? 289  GLU   A CB  1 
ATOM   141  C  CG  . GLU   A 1 26  ? -24.509 -8.391  8.354   1.00 102.05 ? 289  GLU   A CG  1 
ATOM   142  C  CD  . GLU   A 1 26  ? -24.143 -7.432  7.235   1.00 102.13 ? 289  GLU   A CD  1 
ATOM   143  O  OE1 . GLU   A 1 26  ? -23.271 -6.573  7.461   1.00 99.58  ? 289  GLU   A OE1 1 
ATOM   144  O  OE2 . GLU   A 1 26  ? -24.738 -7.539  6.146   1.00 92.57  ? 289  GLU   A OE2 1 
ATOM   145  N  N   . THR   A 1 27  ? -24.539 -12.253 10.028  0.50 119.16 ? 290  THR   A N   1 
ATOM   146  C  CA  . THR   A 1 27  ? -24.335 -12.613 11.455  0.50 118.26 ? 290  THR   A CA  1 
ATOM   147  C  C   . THR   A 1 27  ? -22.903 -13.112 11.682  0.50 115.98 ? 290  THR   A C   1 
ATOM   148  O  O   . THR   A 1 27  ? -22.421 -12.973 12.821  0.50 120.30 ? 290  THR   A O   1 
ATOM   149  C  CB  . THR   A 1 27  ? -25.353 -13.664 11.908  0.50 119.58 ? 290  THR   A CB  1 
ATOM   150  O  OG1 . THR   A 1 27  ? -25.286 -14.760 10.995  0.50 122.69 ? 290  THR   A OG1 1 
ATOM   151  C  CG2 . THR   A 1 27  ? -26.767 -13.128 11.956  0.50 117.58 ? 290  THR   A CG2 1 
ATOM   152  N  N   . SER   A 1 28  ? -22.249 -13.669 10.657  0.50 108.28 ? 291  SER   A N   1 
ATOM   153  C  CA  . SER   A 1 28  ? -20.906 -14.269 10.878  0.50 99.25  ? 291  SER   A CA  1 
ATOM   154  C  C   . SER   A 1 28  ? -19.887 -13.816 9.827   0.50 93.69  ? 291  SER   A C   1 
ATOM   155  O  O   . SER   A 1 28  ? -18.967 -14.598 9.542   0.50 90.84  ? 291  SER   A O   1 
ATOM   156  C  CB  . SER   A 1 28  ? -21.014 -15.768 10.896  0.50 98.41  ? 291  SER   A CB  1 
ATOM   157  O  OG  . SER   A 1 28  ? -21.959 -16.192 11.867  0.50 100.14 ? 291  SER   A OG  1 
ATOM   158  N  N   . TRP   A 1 29  ? -20.016 -12.604 9.286   0.50 92.13  ? 292  TRP   A N   1 
ATOM   159  C  CA  . TRP   A 1 29  ? -19.096 -12.199 8.187   0.50 92.14  ? 292  TRP   A CA  1 
ATOM   160  C  C   . TRP   A 1 29  ? -17.712 -11.864 8.755   0.50 91.36  ? 292  TRP   A C   1 
ATOM   161  O  O   . TRP   A 1 29  ? -17.518 -10.711 9.175   0.50 92.53  ? 292  TRP   A O   1 
ATOM   162  C  CB  . TRP   A 1 29  ? -19.677 -11.033 7.379   0.50 88.75  ? 292  TRP   A CB  1 
ATOM   163  C  CG  . TRP   A 1 29  ? -18.935 -10.747 6.109   0.50 88.24  ? 292  TRP   A CG  1 
ATOM   164  C  CD1 . TRP   A 1 29  ? -18.151 -9.664  5.840   0.50 88.52  ? 292  TRP   A CD1 1 
ATOM   165  C  CD2 . TRP   A 1 29  ? -18.904 -11.566 4.927   0.50 85.89  ? 292  TRP   A CD2 1 
ATOM   166  N  NE1 . TRP   A 1 29  ? -17.639 -9.749  4.573   0.50 87.00  ? 292  TRP   A NE1 1 
ATOM   167  C  CE2 . TRP   A 1 29  ? -18.083 -10.905 3.989   0.50 87.45  ? 292  TRP   A CE2 1 
ATOM   168  C  CE3 . TRP   A 1 29  ? -19.488 -12.785 4.569   0.50 82.96  ? 292  TRP   A CE3 1 
ATOM   169  C  CZ2 . TRP   A 1 29  ? -17.835 -11.426 2.720   0.50 84.74  ? 292  TRP   A CZ2 1 
ATOM   170  C  CZ3 . TRP   A 1 29  ? -19.242 -13.299 3.315   0.50 82.30  ? 292  TRP   A CZ3 1 
ATOM   171  C  CH2 . TRP   A 1 29  ? -18.426 -12.627 2.406   0.50 83.09  ? 292  TRP   A CH2 1 
ATOM   172  N  N   . HIS   A 1 30  ? -16.790 -12.832 8.739   1.00 89.66  ? 293  HIS   A N   1 
ATOM   173  C  CA  . HIS   A 1 30  ? -15.418 -12.603 9.269   1.00 88.74  ? 293  HIS   A CA  1 
ATOM   174  C  C   . HIS   A 1 30  ? -14.380 -12.563 8.147   1.00 88.09  ? 293  HIS   A C   1 
ATOM   175  O  O   . HIS   A 1 30  ? -14.340 -13.514 7.363   1.00 101.14 ? 293  HIS   A O   1 
ATOM   176  C  CB  . HIS   A 1 30  ? -15.048 -13.647 10.328  1.00 84.99  ? 293  HIS   A CB  1 
ATOM   177  C  CG  . HIS   A 1 30  ? -15.241 -15.074 9.957   1.00 78.89  ? 293  HIS   A CG  1 
ATOM   178  N  ND1 . HIS   A 1 30  ? -16.476 -15.682 9.978   1.00 79.93  ? 293  HIS   A ND1 1 
ATOM   179  C  CD2 . HIS   A 1 30  ? -14.348 -16.030 9.637   1.00 85.13  ? 293  HIS   A CD2 1 
ATOM   180  C  CE1 . HIS   A 1 30  ? -16.343 -16.948 9.644   1.00 78.01  ? 293  HIS   A CE1 1 
ATOM   181  N  NE2 . HIS   A 1 30  ? -15.047 -17.186 9.431   1.00 87.18  ? 293  HIS   A NE2 1 
ATOM   182  N  N   . TYR   A 1 31  ? -13.565 -11.507 8.093   1.00 89.23  ? 294  TYR   A N   1 
ATOM   183  C  CA  . TYR   A 1 31  ? -12.476 -11.408 7.086   1.00 94.81  ? 294  TYR   A CA  1 
ATOM   184  C  C   . TYR   A 1 31  ? -11.232 -12.141 7.596   1.00 96.31  ? 294  TYR   A C   1 
ATOM   185  O  O   . TYR   A 1 31  ? -10.201 -11.482 7.804   1.00 98.59  ? 294  TYR   A O   1 
ATOM   186  C  CB  . TYR   A 1 31  ? -12.169 -9.937  6.805   1.00 99.79  ? 294  TYR   A CB  1 
ATOM   187  C  CG  . TYR   A 1 31  ? -11.123 -9.668  5.753   1.00 117.47 ? 294  TYR   A CG  1 
ATOM   188  C  CD1 . TYR   A 1 31  ? -9.944  -9.013  6.071   1.00 121.07 ? 294  TYR   A CD1 1 
ATOM   189  C  CD2 . TYR   A 1 31  ? -11.313 -10.051 4.436   1.00 123.97 ? 294  TYR   A CD2 1 
ATOM   190  C  CE1 . TYR   A 1 31  ? -8.980  -8.751  5.112   1.00 119.37 ? 294  TYR   A CE1 1 
ATOM   191  C  CE2 . TYR   A 1 31  ? -10.360 -9.795  3.464   1.00 118.73 ? 294  TYR   A CE2 1 
ATOM   192  C  CZ  . TYR   A 1 31  ? -9.188  -9.144  3.803   1.00 118.05 ? 294  TYR   A CZ  1 
ATOM   193  O  OH  . TYR   A 1 31  ? -8.242  -8.889  2.854   1.00 116.43 ? 294  TYR   A OH  1 
ATOM   194  N  N   . ASP   A 1 32  ? -11.313 -13.464 7.756   0.50 96.99  ? 295  ASP   A N   1 
ATOM   195  C  CA  . ASP   A 1 32  ? -10.180 -14.239 8.335   0.50 98.87  ? 295  ASP   A CA  1 
ATOM   196  C  C   . ASP   A 1 32  ? -8.848  -13.724 7.779   0.50 104.21 ? 295  ASP   A C   1 
ATOM   197  O  O   . ASP   A 1 32  ? -8.769  -13.478 6.561   0.50 105.74 ? 295  ASP   A O   1 
ATOM   198  C  CB  . ASP   A 1 32  ? -10.341 -15.743 8.097   0.50 94.75  ? 295  ASP   A CB  1 
ATOM   199  C  CG  . ASP   A 1 32  ? -9.176  -16.566 8.617   0.50 91.99  ? 295  ASP   A CG  1 
ATOM   200  O  OD1 . ASP   A 1 32  ? -8.412  -16.041 9.449   0.50 87.95  ? 295  ASP   A OD1 1 
ATOM   201  O  OD2 . ASP   A 1 32  ? -9.038  -17.724 8.180   0.50 89.76  ? 295  ASP   A OD2 1 
ATOM   202  N  N   . GLN   A 1 33  ? -7.829  -13.616 8.636   0.50 108.26 ? 296  GLN   A N   1 
ATOM   203  C  CA  . GLN   A 1 33  ? -6.495  -13.132 8.194   0.50 109.46 ? 296  GLN   A CA  1 
ATOM   204  C  C   . GLN   A 1 33  ? -5.552  -14.327 8.045   0.50 111.09 ? 296  GLN   A C   1 
ATOM   205  O  O   . GLN   A 1 33  ? -4.374  -14.107 7.709   0.50 112.61 ? 296  GLN   A O   1 
ATOM   206  C  CB  . GLN   A 1 33  ? -5.940  -12.113 9.190   0.50 107.94 ? 296  GLN   A CB  1 
ATOM   207  C  CG  . GLN   A 1 33  ? -6.637  -10.761 9.136   0.50 107.22 ? 296  GLN   A CG  1 
ATOM   208  C  CD  . GLN   A 1 33  ? -6.269  -9.978  7.900   0.50 106.88 ? 296  GLN   A CD  1 
ATOM   209  O  OE1 . GLN   A 1 33  ? -5.551  -10.458 7.026   0.50 101.74 ? 296  GLN   A OE1 1 
ATOM   210  N  NE2 . GLN   A 1 33  ? -6.759  -8.751  7.821   0.50 106.96 ? 296  GLN   A NE2 1 
ATOM   211  N  N   . ASP   A 1 34  ? -6.056  -15.538 8.287   0.50 112.80 ? 297  ASP   A N   1 
ATOM   212  C  CA  . ASP   A 1 34  ? -5.220  -16.763 8.164   0.50 117.12 ? 297  ASP   A CA  1 
ATOM   213  C  C   . ASP   A 1 34  ? -5.760  -17.636 7.027   0.50 119.67 ? 297  ASP   A C   1 
ATOM   214  O  O   . ASP   A 1 34  ? -5.546  -18.862 7.083   0.50 122.93 ? 297  ASP   A O   1 
ATOM   215  C  CB  . ASP   A 1 34  ? -5.163  -17.537 9.482   0.50 116.50 ? 297  ASP   A CB  1 
ATOM   216  C  CG  . ASP   A 1 34  ? -4.554  -16.749 10.629  0.50 117.06 ? 297  ASP   A CG  1 
ATOM   217  O  OD1 . ASP   A 1 34  ? -4.007  -15.659 10.368  0.50 118.75 ? 297  ASP   A OD1 1 
ATOM   218  O  OD2 . ASP   A 1 34  ? -4.636  -17.231 11.775  0.50 116.15 ? 297  ASP   A OD2 1 
ATOM   219  N  N   . HIS   A 1 35  ? -6.437  -17.028 6.047   0.50 115.85 ? 298  HIS   A N   1 
ATOM   220  C  CA  . HIS   A 1 35  ? -6.981  -17.784 4.886   0.50 108.50 ? 298  HIS   A CA  1 
ATOM   221  C  C   . HIS   A 1 35  ? -5.828  -18.314 4.027   0.50 104.70 ? 298  HIS   A C   1 
ATOM   222  O  O   . HIS   A 1 35  ? -4.818  -17.597 3.888   0.50 102.91 ? 298  HIS   A O   1 
ATOM   223  C  CB  . HIS   A 1 35  ? -7.926  -16.896 4.071   0.50 105.25 ? 298  HIS   A CB  1 
ATOM   224  C  CG  . HIS   A 1 35  ? -7.245  -15.744 3.413   0.50 101.55 ? 298  HIS   A CG  1 
ATOM   225  N  ND1 . HIS   A 1 35  ? -7.198  -14.490 3.987   0.50 99.47  ? 298  HIS   A ND1 1 
ATOM   226  C  CD2 . HIS   A 1 35  ? -6.582  -15.651 2.240   0.50 100.34 ? 298  HIS   A CD2 1 
ATOM   227  C  CE1 . HIS   A 1 35  ? -6.538  -13.672 3.194   0.50 96.70  ? 298  HIS   A CE1 1 
ATOM   228  N  NE2 . HIS   A 1 35  ? -6.149  -14.360 2.116   0.50 98.37  ? 298  HIS   A NE2 1 
ATOM   229  N  N   . PRO   A 1 36  ? -5.935  -19.527 3.446   0.50 96.80  ? 299  PRO   A N   1 
ATOM   230  C  CA  . PRO   A 1 36  ? -4.844  -20.109 2.667   0.50 93.51  ? 299  PRO   A CA  1 
ATOM   231  C  C   . PRO   A 1 36  ? -4.899  -19.741 1.180   0.50 92.50  ? 299  PRO   A C   1 
ATOM   232  O  O   . PRO   A 1 36  ? -5.075  -20.637 0.379   0.50 90.71  ? 299  PRO   A O   1 
ATOM   233  C  CB  . PRO   A 1 36  ? -5.159  -21.599 2.799   0.50 93.22  ? 299  PRO   A CB  1 
ATOM   234  C  CG  . PRO   A 1 36  ? -6.670  -21.652 2.784   0.50 93.29  ? 299  PRO   A CG  1 
ATOM   235  C  CD  . PRO   A 1 36  ? -7.107  -20.400 3.515   0.50 93.68  ? 299  PRO   A CD  1 
ATOM   236  N  N   . TYR   A 1 37  ? -4.719  -18.463 0.839   0.50 88.73  ? 300  TYR   A N   1 
ATOM   237  C  CA  . TYR   A 1 37  ? -4.883  -18.057 -0.580  0.50 86.10  ? 300  TYR   A CA  1 
ATOM   238  C  C   . TYR   A 1 37  ? -3.815  -17.047 -1.006  0.50 89.08  ? 300  TYR   A C   1 
ATOM   239  O  O   . TYR   A 1 37  ? -3.490  -16.152 -0.206  0.50 90.01  ? 300  TYR   A O   1 
ATOM   240  C  CB  . TYR   A 1 37  ? -6.279  -17.466 -0.791  0.50 79.35  ? 300  TYR   A CB  1 
ATOM   241  C  CG  . TYR   A 1 37  ? -7.425  -18.364 -0.399  0.50 70.12  ? 300  TYR   A CG  1 
ATOM   242  C  CD1 . TYR   A 1 37  ? -7.818  -19.414 -1.211  0.50 67.79  ? 300  TYR   A CD1 1 
ATOM   243  C  CD2 . TYR   A 1 37  ? -8.125  -18.159 0.776   0.50 66.05  ? 300  TYR   A CD2 1 
ATOM   244  C  CE1 . TYR   A 1 37  ? -8.870  -20.243 -0.859  0.50 63.46  ? 300  TYR   A CE1 1 
ATOM   245  C  CE2 . TYR   A 1 37  ? -9.181  -18.976 1.142   0.50 63.00  ? 300  TYR   A CE2 1 
ATOM   246  C  CZ  . TYR   A 1 37  ? -9.555  -20.023 0.321   0.50 61.74  ? 300  TYR   A CZ  1 
ATOM   247  O  OH  . TYR   A 1 37  ? -10.592 -20.835 0.673   0.50 61.42  ? 300  TYR   A OH  1 
ATOM   248  N  N   . LYS   A 1 38  ? -3.295  -17.185 -2.229  0.50 92.52  ? 301  LYS   A N   1 
ATOM   249  C  CA  . LYS   A 1 38  ? -2.317  -16.211 -2.787  0.50 94.03  ? 301  LYS   A CA  1 
ATOM   250  C  C   . LYS   A 1 38  ? -2.590  -16.134 -4.286  0.50 90.03  ? 301  LYS   A C   1 
ATOM   251  O  O   . LYS   A 1 38  ? -2.060  -15.222 -4.940  0.50 87.50  ? 301  LYS   A O   1 
ATOM   252  C  CB  . LYS   A 1 38  ? -0.883  -16.679 -2.525  0.50 97.58  ? 301  LYS   A CB  1 
ATOM   253  C  CG  . LYS   A 1 38  ? 0.215   -15.830 -3.151  0.50 97.82  ? 301  LYS   A CG  1 
ATOM   254  C  CD  . LYS   A 1 38  ? 0.209   -14.393 -2.679  0.50 98.46  ? 301  LYS   A CD  1 
ATOM   255  C  CE  . LYS   A 1 38  ? 1.241   -13.537 -3.381  0.50 98.39  ? 301  LYS   A CE  1 
ATOM   256  N  NZ  . LYS   A 1 38  ? 2.617   -14.037 -3.151  0.50 98.28  ? 301  LYS   A NZ  1 
ATOM   257  N  N   . THR   A 1 39  ? -3.418  -17.044 -4.792  0.50 88.07  ? 302  THR   A N   1 
ATOM   258  C  CA  . THR   A 1 39  ? -3.729  -17.147 -6.246  0.50 85.52  ? 302  THR   A CA  1 
ATOM   259  C  C   . THR   A 1 39  ? -5.178  -16.711 -6.496  0.50 79.71  ? 302  THR   A C   1 
ATOM   260  O  O   . THR   A 1 39  ? -5.412  -16.010 -7.500  0.50 75.98  ? 302  THR   A O   1 
ATOM   261  C  CB  . THR   A 1 39  ? -3.457  -18.564 -6.762  0.50 85.58  ? 302  THR   A CB  1 
ATOM   262  O  OG1 . THR   A 1 39  ? -3.903  -19.467 -5.750  0.50 86.89  ? 302  THR   A OG1 1 
ATOM   263  C  CG2 . THR   A 1 39  ? -1.995  -18.805 -7.071  0.50 86.42  ? 302  THR   A CG2 1 
ATOM   264  N  N   . TRP   A 1 40  ? -6.104  -17.125 -5.625  0.50 73.07  ? 303  TRP   A N   1 
ATOM   265  C  CA  . TRP   A 1 40  ? -7.499  -16.613 -5.574  0.50 69.66  ? 303  TRP   A CA  1 
ATOM   266  C  C   . TRP   A 1 40  ? -7.477  -15.189 -5.006  0.50 68.24  ? 303  TRP   A C   1 
ATOM   267  O  O   . TRP   A 1 40  ? -6.442  -14.802 -4.435  0.50 66.72  ? 303  TRP   A O   1 
ATOM   268  C  CB  . TRP   A 1 40  ? -8.388  -17.528 -4.724  0.50 67.60  ? 303  TRP   A CB  1 
ATOM   269  C  CG  . TRP   A 1 40  ? -8.570  -18.920 -5.250  0.50 66.17  ? 303  TRP   A CG  1 
ATOM   270  C  CD1 . TRP   A 1 40  ? -7.741  -19.987 -5.059  0.50 67.56  ? 303  TRP   A CD1 1 
ATOM   271  C  CD2 . TRP   A 1 40  ? -9.684  -19.416 -6.014  0.50 65.71  ? 303  TRP   A CD2 1 
ATOM   272  N  NE1 . TRP   A 1 40  ? -8.252  -21.105 -5.662  0.50 66.95  ? 303  TRP   A NE1 1 
ATOM   273  C  CE2 . TRP   A 1 40  ? -9.445  -20.786 -6.254  0.50 66.75  ? 303  TRP   A CE2 1 
ATOM   274  C  CE3 . TRP   A 1 40  ? -10.855 -18.840 -6.518  0.50 64.90  ? 303  TRP   A CE3 1 
ATOM   275  C  CZ2 . TRP   A 1 40  ? -10.332 -21.581 -6.977  0.50 64.09  ? 303  TRP   A CZ2 1 
ATOM   276  C  CZ3 . TRP   A 1 40  ? -11.729 -19.627 -7.234  0.50 65.41  ? 303  TRP   A CZ3 1 
ATOM   277  C  CH2 . TRP   A 1 40  ? -11.471 -20.979 -7.458  0.50 62.97  ? 303  TRP   A CH2 1 
ATOM   278  N  N   . ALA   A 1 41  ? -8.633  -14.525 -5.024  0.50 69.32  ? 304  ALA   A N   1 
ATOM   279  C  CA  . ALA   A 1 41  ? -8.773  -13.215 -4.353  0.50 69.75  ? 304  ALA   A CA  1 
ATOM   280  C  C   . ALA   A 1 41  ? -9.761  -13.439 -3.207  0.50 70.38  ? 304  ALA   A C   1 
ATOM   281  O  O   . ALA   A 1 41  ? -10.948 -13.632 -3.502  0.50 71.71  ? 304  ALA   A O   1 
ATOM   282  C  CB  . ALA   A 1 41  ? -9.269  -12.175 -5.316  0.50 67.11  ? 304  ALA   A CB  1 
ATOM   283  N  N   . TYR   A 1 42  ? -9.280  -13.478 -1.962  0.50 75.46  ? 305  TYR   A N   1 
ATOM   284  C  CA  . TYR   A 1 42  ? -10.158 -13.777 -0.798  0.50 77.01  ? 305  TYR   A CA  1 
ATOM   285  C  C   . TYR   A 1 42  ? -11.085 -12.591 -0.534  0.50 78.88  ? 305  TYR   A C   1 
ATOM   286  O  O   . TYR   A 1 42  ? -10.652 -11.438 -0.719  0.50 82.38  ? 305  TYR   A O   1 
ATOM   287  C  CB  . TYR   A 1 42  ? -9.315  -14.106 0.436   0.50 75.93  ? 305  TYR   A CB  1 
ATOM   288  C  CG  . TYR   A 1 42  ? -10.089 -14.284 1.716   0.50 74.12  ? 305  TYR   A CG  1 
ATOM   289  C  CD1 . TYR   A 1 42  ? -10.771 -15.459 1.982   0.50 71.65  ? 305  TYR   A CD1 1 
ATOM   290  C  CD2 . TYR   A 1 42  ? -10.127 -13.282 2.670   0.50 74.33  ? 305  TYR   A CD2 1 
ATOM   291  C  CE1 . TYR   A 1 42  ? -11.479 -15.631 3.160   0.50 72.54  ? 305  TYR   A CE1 1 
ATOM   292  C  CE2 . TYR   A 1 42  ? -10.829 -13.437 3.853   0.50 73.41  ? 305  TYR   A CE2 1 
ATOM   293  C  CZ  . TYR   A 1 42  ? -11.508 -14.616 4.098   0.50 73.37  ? 305  TYR   A CZ  1 
ATOM   294  O  OH  . TYR   A 1 42  ? -12.202 -14.772 5.262   0.50 72.67  ? 305  TYR   A OH  1 
ATOM   295  N  N   . HIS   A 1 43  ? -12.318 -12.870 -0.109  1.00 76.93  ? 306  HIS   A N   1 
ATOM   296  C  CA  . HIS   A 1 43  ? -13.303 -11.776 0.096   1.00 74.92  ? 306  HIS   A CA  1 
ATOM   297  C  C   . HIS   A 1 43  ? -13.889 -11.820 1.513   1.00 73.26  ? 306  HIS   A C   1 
ATOM   298  O  O   . HIS   A 1 43  ? -14.150 -10.738 2.056   1.00 86.15  ? 306  HIS   A O   1 
ATOM   299  C  CB  . HIS   A 1 43  ? -14.385 -11.819 -0.993  1.00 72.94  ? 306  HIS   A CB  1 
ATOM   300  C  CG  . HIS   A 1 43  ? -13.909 -11.427 -2.349  1.00 66.73  ? 306  HIS   A CG  1 
ATOM   301  N  ND1 . HIS   A 1 43  ? -13.740 -10.111 -2.717  1.00 61.54  ? 306  HIS   A ND1 1 
ATOM   302  C  CD2 . HIS   A 1 43  ? -13.589 -12.167 -3.430  1.00 62.65  ? 306  HIS   A CD2 1 
ATOM   303  C  CE1 . HIS   A 1 43  ? -13.323 -10.055 -3.963  1.00 60.86  ? 306  HIS   A CE1 1 
ATOM   304  N  NE2 . HIS   A 1 43  ? -13.223 -11.302 -4.422  1.00 60.32  ? 306  HIS   A NE2 1 
ATOM   305  N  N   . GLY   A 1 44  ? -14.103 -13.007 2.082   1.00 67.49  ? 307  GLY   A N   1 
ATOM   306  C  CA  . GLY   A 1 44  ? -14.737 -13.091 3.411   1.00 70.09  ? 307  GLY   A CA  1 
ATOM   307  C  C   . GLY   A 1 44  ? -15.099 -14.508 3.802   1.00 74.49  ? 307  GLY   A C   1 
ATOM   308  O  O   . GLY   A 1 44  ? -14.847 -15.414 3.000   1.00 76.00  ? 307  GLY   A O   1 
ATOM   309  N  N   . SER   A 1 45  ? -15.679 -14.690 4.991   0.50 75.55  ? 308  SER   A N   1 
ATOM   310  C  CA  . SER   A 1 45  ? -16.013 -16.052 5.486   0.50 76.72  ? 308  SER   A CA  1 
ATOM   311  C  C   . SER   A 1 45  ? -17.298 -16.016 6.315   0.50 76.44  ? 308  SER   A C   1 
ATOM   312  O  O   . SER   A 1 45  ? -17.635 -14.932 6.813   0.50 80.54  ? 308  SER   A O   1 
ATOM   313  C  CB  . SER   A 1 45  ? -14.874 -16.629 6.284   0.50 77.95  ? 308  SER   A CB  1 
ATOM   314  O  OG  . SER   A 1 45  ? -13.692 -16.701 5.502   0.50 75.93  ? 308  SER   A OG  1 
ATOM   315  N  N   . TYR   A 1 46  ? -17.976 -17.162 6.455   0.50 76.44  ? 309  TYR   A N   1 
ATOM   316  C  CA  . TYR   A 1 46  ? -19.207 -17.230 7.292   0.50 76.33  ? 309  TYR   A CA  1 
ATOM   317  C  C   . TYR   A 1 46  ? -19.396 -18.640 7.871   0.50 78.55  ? 309  TYR   A C   1 
ATOM   318  O  O   . TYR   A 1 46  ? -18.792 -19.584 7.341   0.50 80.73  ? 309  TYR   A O   1 
ATOM   319  C  CB  . TYR   A 1 46  ? -20.428 -16.703 6.528   0.50 75.89  ? 309  TYR   A CB  1 
ATOM   320  C  CG  . TYR   A 1 46  ? -20.979 -17.574 5.428   0.50 73.96  ? 309  TYR   A CG  1 
ATOM   321  C  CD1 . TYR   A 1 46  ? -21.817 -18.637 5.713   0.50 72.93  ? 309  TYR   A CD1 1 
ATOM   322  C  CD2 . TYR   A 1 46  ? -20.709 -17.301 4.098   0.50 72.93  ? 309  TYR   A CD2 1 
ATOM   323  C  CE1 . TYR   A 1 46  ? -22.347 -19.428 4.707   0.50 74.56  ? 309  TYR   A CE1 1 
ATOM   324  C  CE2 . TYR   A 1 46  ? -21.231 -18.080 3.080   0.50 71.98  ? 309  TYR   A CE2 1 
ATOM   325  C  CZ  . TYR   A 1 46  ? -22.052 -19.150 3.385   0.50 74.35  ? 309  TYR   A CZ  1 
ATOM   326  O  OH  . TYR   A 1 46  ? -22.571 -19.929 2.392   0.50 67.57  ? 309  TYR   A OH  1 
ATOM   327  N  N   . GLU   A 1 47  ? -20.231 -18.776 8.902   0.50 81.37  ? 310  GLU   A N   1 
ATOM   328  C  CA  . GLU   A 1 47  ? -20.439 -20.058 9.635   0.50 84.72  ? 310  GLU   A CA  1 
ATOM   329  C  C   . GLU   A 1 47  ? -21.265 -21.025 8.778   0.50 86.01  ? 310  GLU   A C   1 
ATOM   330  O  O   . GLU   A 1 47  ? -22.311 -20.594 8.253   0.50 91.36  ? 310  GLU   A O   1 
ATOM   331  C  CB  . GLU   A 1 47  ? -21.128 -19.757 10.971  0.50 87.85  ? 310  GLU   A CB  1 
ATOM   332  C  CG  . GLU   A 1 47  ? -21.522 -20.983 11.779  0.50 87.65  ? 310  GLU   A CG  1 
ATOM   333  C  CD  . GLU   A 1 47  ? -21.832 -20.680 13.237  0.50 89.26  ? 310  GLU   A CD  1 
ATOM   334  O  OE1 . GLU   A 1 47  ? -22.992 -20.889 13.659  0.50 83.61  ? 310  GLU   A OE1 1 
ATOM   335  O  OE2 . GLU   A 1 47  ? -20.909 -20.228 13.951  0.50 92.94  ? 310  GLU   A OE2 1 
ATOM   336  N  N   . THR   A 1 48  ? -20.823 -22.286 8.664   0.50 85.79  ? 311  THR   A N   1 
ATOM   337  C  CA  . THR   A 1 48  ? -21.447 -23.340 7.814   0.50 84.59  ? 311  THR   A CA  1 
ATOM   338  C  C   . THR   A 1 48  ? -21.411 -24.698 8.527   0.50 82.42  ? 311  THR   A C   1 
ATOM   339  O  O   . THR   A 1 48  ? -20.716 -24.805 9.557   0.50 86.35  ? 311  THR   A O   1 
ATOM   340  C  CB  . THR   A 1 48  ? -20.752 -23.436 6.449   0.50 86.57  ? 311  THR   A CB  1 
ATOM   341  O  OG1 . THR   A 1 48  ? -19.344 -23.550 6.663   0.50 88.95  ? 311  THR   A OG1 1 
ATOM   342  C  CG2 . THR   A 1 48  ? -21.023 -22.241 5.561   0.50 88.69  ? 311  THR   A CG2 1 
ATOM   343  N  N   . LYS   A 1 49  ? -22.139 -25.686 7.991   0.50 79.88  ? 312  LYS   A N   1 
ATOM   344  C  CA  . LYS   A 1 49  ? -22.136 -27.102 8.453   0.50 79.00  ? 312  LYS   A CA  1 
ATOM   345  C  C   . LYS   A 1 49  ? -22.528 -28.017 7.285   0.50 78.68  ? 312  LYS   A C   1 
ATOM   346  O  O   . LYS   A 1 49  ? -21.994 -29.147 7.238   0.50 75.07  ? 312  LYS   A O   1 
ATOM   347  C  CB  . LYS   A 1 49  ? -23.093 -27.295 9.633   0.50 77.45  ? 312  LYS   A CB  1 
ATOM   348  C  CG  . LYS   A 1 49  ? -23.112 -28.703 10.214  0.50 78.36  ? 312  LYS   A CG  1 
ATOM   349  C  CD  . LYS   A 1 49  ? -23.868 -28.826 11.524  0.50 77.92  ? 312  LYS   A CD  1 
ATOM   350  C  CE  . LYS   A 1 49  ? -23.198 -28.106 12.676  0.50 76.99  ? 312  LYS   A CE  1 
ATOM   351  N  NZ  . LYS   A 1 49  ? -23.983 -28.233 13.926  0.50 75.34  ? 312  LYS   A NZ  1 
ATOM   352  N  N   . SER   A 1 56  ? -19.017 -43.685 -1.407  0.50 47.00  ? 319  SER   A N   1 
ATOM   353  C  CA  . SER   A 1 56  ? -18.258 -44.853 -1.930  0.50 44.98  ? 319  SER   A CA  1 
ATOM   354  C  C   . SER   A 1 56  ? -18.753 -46.141 -1.260  0.50 42.25  ? 319  SER   A C   1 
ATOM   355  O  O   . SER   A 1 56  ? -18.015 -46.687 -0.420  0.50 38.39  ? 319  SER   A O   1 
ATOM   356  C  CB  . SER   A 1 56  ? -16.768 -44.677 -1.739  0.50 46.56  ? 319  SER   A CB  1 
ATOM   357  O  OG  . SER   A 1 56  ? -16.053 -45.784 -2.283  0.50 46.68  ? 319  SER   A OG  1 
ATOM   358  N  N   . MET   A 1 57  ? -19.941 -46.619 -1.659  0.50 39.53  ? 320  MET   A N   1 
ATOM   359  C  CA  . MET   A 1 57  ? -20.596 -47.846 -1.124  0.50 35.50  ? 320  MET   A CA  1 
ATOM   360  C  C   . MET   A 1 57  ? -20.433 -49.009 -2.114  0.50 30.10  ? 320  MET   A C   1 
ATOM   361  O  O   . MET   A 1 57  ? -20.375 -48.762 -3.325  0.50 29.16  ? 320  MET   A O   1 
ATOM   362  C  CB  . MET   A 1 57  ? -22.079 -47.558 -0.897  0.50 39.32  ? 320  MET   A CB  1 
ATOM   363  C  CG  . MET   A 1 57  ? -22.329 -46.133 -0.416  0.50 40.80  ? 320  MET   A CG  1 
ATOM   364  S  SD  . MET   A 1 57  ? -21.549 -45.811 1.188   0.50 43.23  ? 320  MET   A SD  1 
ATOM   365  C  CE  . MET   A 1 57  ? -22.739 -46.567 2.294   0.50 40.99  ? 320  MET   A CE  1 
ATOM   366  N  N   . VAL   A 1 58  ? -20.377 -50.244 -1.626  0.50 27.32  ? 321  VAL   A N   1 
ATOM   367  C  CA  . VAL   A 1 58  ? -20.164 -51.438 -2.493  0.50 28.23  ? 321  VAL   A CA  1 
ATOM   368  C  C   . VAL   A 1 58  ? -21.508 -52.018 -2.947  0.50 28.03  ? 321  VAL   A C   1 
ATOM   369  O  O   . VAL   A 1 58  ? -22.382 -52.220 -2.093  0.50 27.23  ? 321  VAL   A O   1 
ATOM   370  C  CB  . VAL   A 1 58  ? -19.317 -52.517 -1.799  0.50 28.16  ? 321  VAL   A CB  1 
ATOM   371  C  CG1 . VAL   A 1 58  ? -19.359 -53.830 -2.571  0.50 27.90  ? 321  VAL   A CG1 1 
ATOM   372  C  CG2 . VAL   A 1 58  ? -17.886 -52.049 -1.610  0.50 29.31  ? 321  VAL   A CG2 1 
ATOM   373  N  N   . ASN   A 1 59  ? -21.610 -52.317 -4.244  1.00 26.87  ? 322  ASN   A N   1 
ATOM   374  C  CA  . ASN   A 1 59  ? -22.745 -53.022 -4.854  1.00 27.72  ? 322  ASN   A CA  1 
ATOM   375  C  C   . ASN   A 1 59  ? -22.652 -54.503 -4.506  1.00 27.61  ? 322  ASN   A C   1 
ATOM   376  O  O   . ASN   A 1 59  ? -21.804 -55.215 -5.110  1.00 26.08  ? 322  ASN   A O   1 
ATOM   377  C  CB  . ASN   A 1 59  ? -22.730 -52.798 -6.370  1.00 27.56  ? 322  ASN   A CB  1 
ATOM   378  C  CG  . ASN   A 1 59  ? -23.919 -53.452 -7.050  1.00 28.15  ? 322  ASN   A CG  1 
ATOM   379  O  OD1 . ASN   A 1 59  ? -24.334 -54.569 -6.691  1.00 27.92  ? 322  ASN   A OD1 1 
ATOM   380  N  ND2 . ASN   A 1 59  ? -24.489 -52.743 -8.010  1.00 30.31  ? 322  ASN   A ND2 1 
ATOM   381  N  N   . GLY   A 1 60  ? -23.503 -54.991 -3.621  1.00 26.27  ? 323  GLY   A N   1 
ATOM   382  C  CA  . GLY   A 1 60  ? -23.396 -56.385 -3.143  1.00 25.78  ? 323  GLY   A CA  1 
ATOM   383  C  C   . GLY   A 1 60  ? -23.778 -57.415 -4.202  1.00 28.39  ? 323  GLY   A C   1 
ATOM   384  O  O   . GLY   A 1 60  ? -23.257 -58.563 -4.196  1.00 29.34  ? 323  GLY   A O   1 
ATOM   385  N  N   . VAL   A 1 61  ? -24.632 -57.044 -5.141  1.00 27.38  ? 324  VAL   A N   1 
ATOM   386  C  CA  . VAL   A 1 61  ? -25.006 -57.992 -6.222  1.00 26.82  ? 324  VAL   A CA  1 
ATOM   387  C  C   . VAL   A 1 61  ? -23.752 -58.279 -7.054  1.00 24.03  ? 324  VAL   A C   1 
ATOM   388  O  O   . VAL   A 1 61  ? -23.417 -59.462 -7.233  1.00 23.18  ? 324  VAL   A O   1 
ATOM   389  C  CB  . VAL   A 1 61  ? -26.213 -57.462 -7.022  1.00 25.35  ? 324  VAL   A CB  1 
ATOM   390  C  CG1 . VAL   A 1 61  ? -26.419 -58.225 -8.288  1.00 24.20  ? 324  VAL   A CG1 1 
ATOM   391  C  CG2 . VAL   A 1 61  ? -27.468 -57.482 -6.178  1.00 27.73  ? 324  VAL   A CG2 1 
ATOM   392  N  N   . VAL   A 1 62  ? -23.057 -57.257 -7.546  1.00 25.06  ? 325  VAL   A N   1 
ATOM   393  C  CA  . VAL   A 1 62  ? -21.803 -57.463 -8.339  1.00 26.57  ? 325  VAL   A CA  1 
ATOM   394  C  C   . VAL   A 1 62  ? -20.722 -58.159 -7.482  1.00 26.13  ? 325  VAL   A C   1 
ATOM   395  O  O   . VAL   A 1 62  ? -20.121 -59.130 -7.972  1.00 24.30  ? 325  VAL   A O   1 
ATOM   396  C  CB  . VAL   A 1 62  ? -21.254 -56.161 -8.933  1.00 24.21  ? 325  VAL   A CB  1 
ATOM   397  C  CG1 . VAL   A 1 62  ? -20.004 -56.455 -9.725  1.00 24.69  ? 325  VAL   A CG1 1 
ATOM   398  C  CG2 . VAL   A 1 62  ? -22.286 -55.463 -9.800  1.00 24.72  ? 325  VAL   A CG2 1 
ATOM   399  N  N   . ARG   A 1 63  ? -20.551 -57.771 -6.221  1.00 26.12  ? 326  ARG   A N   1 
ATOM   400  C  CA  . ARG   A 1 63  ? -19.459 -58.346 -5.413  1.00 28.11  ? 326  ARG   A CA  1 
ATOM   401  C  C   . ARG   A 1 63  ? -19.743 -59.832 -5.153  1.00 28.03  ? 326  ARG   A C   1 
ATOM   402  O  O   . ARG   A 1 63  ? -18.809 -60.623 -5.279  1.00 27.98  ? 326  ARG   A O   1 
ATOM   403  C  CB  . ARG   A 1 63  ? -19.152 -57.552 -4.151  1.00 26.52  ? 326  ARG   A CB  1 
ATOM   404  C  CG  . ARG   A 1 63  ? -18.143 -58.276 -3.270  1.00 26.37  ? 326  ARG   A CG  1 
ATOM   405  C  CD  . ARG   A 1 63  ? -17.447 -57.393 -2.268  1.00 24.96  ? 326  ARG   A CD  1 
ATOM   406  N  NE  . ARG   A 1 63  ? -18.382 -56.873 -1.285  1.00 27.76  ? 326  ARG   A NE  1 
ATOM   407  C  CZ  . ARG   A 1 63  ? -18.027 -56.064 -0.293  1.00 29.16  ? 326  ARG   A CZ  1 
ATOM   408  N  NH1 . ARG   A 1 63  ? -16.749 -55.771 -0.126  1.00 26.22  ? 326  ARG   A NH1 1 
ATOM   409  N  NH2 . ARG   A 1 63  ? -18.932 -55.570 0.537   1.00 28.44  ? 326  ARG   A NH2 1 
ATOM   410  N  N   . LEU   A 1 64  ? -20.967 -60.248 -4.885  1.00 26.18  ? 327  LEU   A N   1 
ATOM   411  C  CA  . LEU   A 1 64  ? -21.244 -61.691 -4.616  1.00 25.13  ? 327  LEU   A CA  1 
ATOM   412  C  C   . LEU   A 1 64  ? -20.997 -62.535 -5.875  1.00 22.89  ? 327  LEU   A C   1 
ATOM   413  O  O   . LEU   A 1 64  ? -20.702 -63.766 -5.757  1.00 25.68  ? 327  LEU   A O   1 
ATOM   414  C  CB  . LEU   A 1 64  ? -22.686 -61.866 -4.112  1.00 25.51  ? 327  LEU   A CB  1 
ATOM   415  C  CG  . LEU   A 1 64  ? -22.915 -61.521 -2.634  1.00 26.78  ? 327  LEU   A CG  1 
ATOM   416  C  CD1 . LEU   A 1 64  ? -24.379 -61.742 -2.226  1.00 28.50  ? 327  LEU   A CD1 1 
ATOM   417  C  CD2 . LEU   A 1 64  ? -22.058 -62.363 -1.706  1.00 26.20  ? 327  LEU   A CD2 1 
ATOM   418  N  N   . LEU   A 1 65  ? -21.115 -61.945 -7.058  1.00 24.37  ? 328  LEU   A N   1 
ATOM   419  C  CA  . LEU   A 1 65  ? -20.923 -62.688 -8.344  1.00 24.22  ? 328  LEU   A CA  1 
ATOM   420  C  C   . LEU   A 1 65  ? -19.510 -62.477 -8.912  1.00 24.10  ? 328  LEU   A C   1 
ATOM   421  O  O   . LEU   A 1 65  ? -19.250 -62.988 -10.002 1.00 26.21  ? 328  LEU   A O   1 
ATOM   422  C  CB  . LEU   A 1 65  ? -22.023 -62.286 -9.320  1.00 25.48  ? 328  LEU   A CB  1 
ATOM   423  C  CG  . LEU   A 1 65  ? -23.423 -62.637 -8.795  1.00 26.45  ? 328  LEU   A CG  1 
ATOM   424  C  CD1 . LEU   A 1 65  ? -24.518 -62.043 -9.655  1.00 26.69  ? 328  LEU   A CD1 1 
ATOM   425  C  CD2 . LEU   A 1 65  ? -23.589 -64.144 -8.726  1.00 29.82  ? 328  LEU   A CD2 1 
ATOM   426  N  N   . THR   A 1 66  ? -18.611 -61.849 -8.161  1.00 23.34  ? 329  THR   A N   1 
ATOM   427  C  CA  . THR   A 1 66  ? -17.180 -61.691 -8.550  1.00 22.39  ? 329  THR   A CA  1 
ATOM   428  C  C   . THR   A 1 66  ? -16.255 -62.045 -7.358  1.00 23.21  ? 329  THR   A C   1 
ATOM   429  O  O   . THR   A 1 66  ? -15.250 -61.356 -7.123  1.00 27.09  ? 329  THR   A O   1 
ATOM   430  C  CB  . THR   A 1 66  ? -16.939 -60.277 -9.127  1.00 22.18  ? 329  THR   A CB  1 
ATOM   431  O  OG1 . THR   A 1 66  ? -17.387 -59.294 -8.185  1.00 19.92  ? 329  THR   A OG1 1 
ATOM   432  C  CG2 . THR   A 1 66  ? -17.593 -60.060 -10.477 1.00 23.16  ? 329  THR   A CG2 1 
ATOM   433  N  N   . LYS   A 1 67  ? -16.439 -63.200 -6.755  1.00 21.99  ? 330  LYS   A N   1 
ATOM   434  C  CA  . LYS   A 1 67  ? -15.752 -63.584 -5.504  1.00 24.12  ? 330  LYS   A CA  1 
ATOM   435  C  C   . LYS   A 1 67  ? -14.229 -63.723 -5.681  1.00 23.30  ? 330  LYS   A C   1 
ATOM   436  O  O   . LYS   A 1 67  ? -13.502 -63.355 -4.762  1.00 25.74  ? 330  LYS   A O   1 
ATOM   437  C  CB  . LYS   A 1 67  ? -16.339 -64.885 -4.954  1.00 26.98  ? 330  LYS   A CB  1 
ATOM   438  C  CG  . LYS   A 1 67  ? -15.723 -65.364 -3.655  1.00 27.21  ? 330  LYS   A CG  1 
ATOM   439  C  CD  . LYS   A 1 67  ? -16.265 -66.692 -3.237  1.00 31.54  ? 330  LYS   A CD  1 
ATOM   440  C  CE  . LYS   A 1 67  ? -16.388 -66.748 -1.733  1.00 37.94  ? 330  LYS   A CE  1 
ATOM   441  N  NZ  . LYS   A 1 67  ? -16.307 -68.142 -1.264  1.00 41.12  ? 330  LYS   A NZ  1 
ATOM   442  N  N   . PRO   A 1 68  ? -13.675 -64.231 -6.788  1.00 22.16  ? 331  PRO   A N   1 
ATOM   443  C  CA  . PRO   A 1 68  ? -12.210 -64.322 -6.925  1.00 24.25  ? 331  PRO   A CA  1 
ATOM   444  C  C   . PRO   A 1 68  ? -11.525 -62.969 -6.683  1.00 24.43  ? 331  PRO   A C   1 
ATOM   445  O  O   . PRO   A 1 68  ? -10.366 -62.920 -6.225  1.00 23.43  ? 331  PRO   A O   1 
ATOM   446  C  CB  . PRO   A 1 68  ? -11.994 -64.799 -8.372  1.00 24.52  ? 331  PRO   A CB  1 
ATOM   447  C  CG  . PRO   A 1 68  ? -13.241 -65.605 -8.628  1.00 28.85  ? 331  PRO   A CG  1 
ATOM   448  C  CD  . PRO   A 1 68  ? -14.362 -64.839 -7.929  1.00 25.47  ? 331  PRO   A CD  1 
ATOM   449  N  N   . TRP   A 1 69  ? -12.235 -61.868 -6.968  1.00 23.64  ? 332  TRP   A N   1 
ATOM   450  C  CA  . TRP   A 1 69  ? -11.629 -60.509 -6.919  1.00 25.01  ? 332  TRP   A CA  1 
ATOM   451  C  C   . TRP   A 1 69  ? -11.648 -59.987 -5.475  1.00 27.09  ? 332  TRP   A C   1 
ATOM   452  O  O   . TRP   A 1 69  ? -11.002 -58.961 -5.187  1.00 29.94  ? 332  TRP   A O   1 
ATOM   453  C  CB  . TRP   A 1 69  ? -12.296 -59.612 -7.978  1.00 26.44  ? 332  TRP   A CB  1 
ATOM   454  C  CG  . TRP   A 1 69  ? -11.907 -60.041 -9.360  1.00 24.84  ? 332  TRP   A CG  1 
ATOM   455  C  CD1 . TRP   A 1 69  ? -10.821 -59.596 -10.054 1.00 25.81  ? 332  TRP   A CD1 1 
ATOM   456  C  CD2 . TRP   A 1 69  ? -12.511 -61.059 -10.178 1.00 25.28  ? 332  TRP   A CD2 1 
ATOM   457  N  NE1 . TRP   A 1 69  ? -10.712 -60.262 -11.240 1.00 26.00  ? 332  TRP   A NE1 1 
ATOM   458  C  CE2 . TRP   A 1 69  ? -11.734 -61.155 -11.348 1.00 24.44  ? 332  TRP   A CE2 1 
ATOM   459  C  CE3 . TRP   A 1 69  ? -13.655 -61.856 -10.070 1.00 26.21  ? 332  TRP   A CE3 1 
ATOM   460  C  CZ2 . TRP   A 1 69  ? -12.055 -62.010 -12.398 1.00 26.25  ? 332  TRP   A CZ2 1 
ATOM   461  C  CZ3 . TRP   A 1 69  ? -13.950 -62.731 -11.085 1.00 24.64  ? 332  TRP   A CZ3 1 
ATOM   462  C  CH2 . TRP   A 1 69  ? -13.165 -62.799 -12.240 1.00 24.96  ? 332  TRP   A CH2 1 
ATOM   463  N  N   . ASP   A 1 70  ? -12.268 -60.723 -4.547  1.00 26.05  ? 333  ASP   A N   1 
ATOM   464  C  CA  . ASP   A 1 70  ? -12.311 -60.286 -3.129  1.00 24.61  ? 333  ASP   A CA  1 
ATOM   465  C  C   . ASP   A 1 70  ? -10.894 -60.233 -2.529  1.00 26.87  ? 333  ASP   A C   1 
ATOM   466  O  O   . ASP   A 1 70  ? -10.747 -59.631 -1.436  1.00 24.67  ? 333  ASP   A O   1 
ATOM   467  C  CB  . ASP   A 1 70  ? -13.216 -61.192 -2.310  1.00 26.86  ? 333  ASP   A CB  1 
ATOM   468  C  CG  . ASP   A 1 70  ? -14.699 -61.040 -2.631  1.00 26.25  ? 333  ASP   A CG  1 
ATOM   469  O  OD1 . ASP   A 1 70  ? -15.063 -60.070 -3.363  1.00 26.11  ? 333  ASP   A OD1 1 
ATOM   470  O  OD2 . ASP   A 1 70  ? -15.471 -61.873 -2.120  1.00 26.68  ? 333  ASP   A OD2 1 
ATOM   471  N  N   . ILE   A 1 71  ? -9.895  -60.847 -3.180  1.00 29.02  ? 334  ILE   A N   1 
ATOM   472  C  CA  . ILE   A 1 71  ? -8.516  -60.982 -2.630  1.00 25.16  ? 334  ILE   A CA  1 
ATOM   473  C  C   . ILE   A 1 71  ? -7.525  -60.241 -3.544  1.00 30.45  ? 334  ILE   A C   1 
ATOM   474  O  O   . ILE   A 1 71  ? -6.302  -60.323 -3.284  1.00 34.20  ? 334  ILE   A O   1 
ATOM   475  C  CB  . ILE   A 1 71  ? -8.163  -62.465 -2.362  1.00 27.60  ? 334  ILE   A CB  1 
ATOM   476  C  CG1 . ILE   A 1 71  ? -8.213  -63.356 -3.600  1.00 29.58  ? 334  ILE   A CG1 1 
ATOM   477  C  CG2 . ILE   A 1 71  ? -9.012  -63.060 -1.263  1.00 26.84  ? 334  ILE   A CG2 1 
ATOM   478  C  CD1 . ILE   A 1 71  ? -7.394  -64.614 -3.469  1.00 34.60  ? 334  ILE   A CD1 1 
ATOM   479  N  N   . ILE   A 1 72  ? -7.999  -59.466 -4.527  1.00 27.52  ? 335  ILE   A N   1 
ATOM   480  C  CA  . ILE   A 1 72  ? -7.166  -58.668 -5.453  1.00 25.74  ? 335  ILE   A CA  1 
ATOM   481  C  C   . ILE   A 1 72  ? -7.203  -57.230 -4.967  1.00 29.57  ? 335  ILE   A C   1 
ATOM   482  O  O   . ILE   A 1 72  ? -8.216  -56.549 -5.156  1.00 28.19  ? 335  ILE   A O   1 
ATOM   483  C  CB  . ILE   A 1 72  ? -7.684  -58.762 -6.901  1.00 31.12  ? 335  ILE   A CB  1 
ATOM   484  C  CG1 . ILE   A 1 72  ? -7.806  -60.194 -7.416  1.00 32.22  ? 335  ILE   A CG1 1 
ATOM   485  C  CG2 . ILE   A 1 72  ? -6.871  -57.879 -7.854  1.00 29.56  ? 335  ILE   A CG2 1 
ATOM   486  C  CD1 . ILE   A 1 72  ? -6.517  -60.908 -7.520  1.00 35.41  ? 335  ILE   A CD1 1 
ATOM   487  N  N   . PRO   A 1 73  ? -6.105  -56.721 -4.347  1.00 33.99  ? 336  PRO   A N   1 
ATOM   488  C  CA  . PRO   A 1 73  ? -6.050  -55.356 -3.799  1.00 32.15  ? 336  PRO   A CA  1 
ATOM   489  C  C   . PRO   A 1 73  ? -6.344  -54.229 -4.790  1.00 32.93  ? 336  PRO   A C   1 
ATOM   490  O  O   . PRO   A 1 73  ? -6.989  -53.284 -4.416  1.00 35.34  ? 336  PRO   A O   1 
ATOM   491  C  CB  . PRO   A 1 73  ? -4.595  -55.221 -3.330  1.00 37.47  ? 336  PRO   A CB  1 
ATOM   492  C  CG  . PRO   A 1 73  ? -4.272  -56.642 -2.925  1.00 37.66  ? 336  PRO   A CG  1 
ATOM   493  C  CD  . PRO   A 1 73  ? -4.892  -57.489 -4.030  1.00 33.51  ? 336  PRO   A CD  1 
ATOM   494  N  N   . MET   A 1 74  ? -5.966  -54.388 -6.050  1.00 33.40  ? 337  MET   A N   1 
ATOM   495  C  CA  . MET   A 1 74  ? -6.281  -53.373 -7.085  1.00 35.73  ? 337  MET   A CA  1 
ATOM   496  C  C   . MET   A 1 74  ? -7.810  -53.208 -7.201  1.00 35.49  ? 337  MET   A C   1 
ATOM   497  O  O   . MET   A 1 74  ? -8.257  -52.083 -7.447  1.00 37.36  ? 337  MET   A O   1 
ATOM   498  C  CB  . MET   A 1 74  ? -5.667  -53.784 -8.423  1.00 40.91  ? 337  MET   A CB  1 
ATOM   499  C  CG  . MET   A 1 74  ? -4.130  -53.768 -8.389  1.00 49.82  ? 337  MET   A CG  1 
ATOM   500  S  SD  . MET   A 1 74  ? -3.453  -52.069 -8.040  1.00 65.40  ? 337  MET   A SD  1 
ATOM   501  C  CE  . MET   A 1 74  ? -4.516  -51.060 -9.080  1.00 57.70  ? 337  MET   A CE  1 
ATOM   502  N  N   . VAL   A 1 75  ? -8.583  -54.278 -7.021  1.00 27.37  ? 338  VAL   A N   1 
ATOM   503  C  CA  . VAL   A 1 75  ? -10.082 -54.225 -6.990  1.00 27.99  ? 338  VAL   A CA  1 
ATOM   504  C  C   . VAL   A 1 75  ? -10.561 -53.696 -5.635  1.00 27.13  ? 338  VAL   A C   1 
ATOM   505  O  O   . VAL   A 1 75  ? -11.319 -52.768 -5.645  1.00 33.46  ? 338  VAL   A O   1 
ATOM   506  C  CB  . VAL   A 1 75  ? -10.735 -55.587 -7.301  1.00 25.68  ? 338  VAL   A CB  1 
ATOM   507  C  CG1 . VAL   A 1 75  ? -12.254 -55.550 -7.010  1.00 25.12  ? 338  VAL   A CG1 1 
ATOM   508  C  CG2 . VAL   A 1 75  ? -10.478 -55.979 -8.751  1.00 24.32  ? 338  VAL   A CG2 1 
ATOM   509  N  N   . THR   A 1 76  ? -10.191 -54.321 -4.520  1.00 30.37  ? 339  THR   A N   1 
ATOM   510  C  CA  . THR   A 1 76  ? -10.787 -54.032 -3.186  1.00 32.16  ? 339  THR   A CA  1 
ATOM   511  C  C   . THR   A 1 76  ? -10.416 -52.620 -2.727  1.00 32.36  ? 339  THR   A C   1 
ATOM   512  O  O   . THR   A 1 76  ? -11.272 -51.960 -2.110  1.00 34.07  ? 339  THR   A O   1 
ATOM   513  C  CB  . THR   A 1 76  ? -10.350 -55.056 -2.140  1.00 34.22  ? 339  THR   A CB  1 
ATOM   514  O  OG1 . THR   A 1 76  ? -8.927  -55.001 -1.957  1.00 38.19  ? 339  THR   A OG1 1 
ATOM   515  C  CG2 . THR   A 1 76  ? -10.759 -56.452 -2.553  1.00 37.37  ? 339  THR   A CG2 1 
ATOM   516  N  N   . GLN   A 1 77  ? -9.217  -52.146 -3.044  1.00 32.31  ? 340  GLN   A N   1 
ATOM   517  C  CA  . GLN   A 1 77  ? -8.752  -50.801 -2.579  1.00 37.24  ? 340  GLN   A CA  1 
ATOM   518  C  C   . GLN   A 1 77  ? -9.509  -49.696 -3.295  1.00 30.09  ? 340  GLN   A C   1 
ATOM   519  O  O   . GLN   A 1 77  ? -9.563  -48.615 -2.730  1.00 30.15  ? 340  GLN   A O   1 
ATOM   520  C  CB  . GLN   A 1 77  ? -7.273  -50.541 -2.828  1.00 36.97  ? 340  GLN   A CB  1 
ATOM   521  C  CG  . GLN   A 1 77  ? -6.393  -51.622 -2.270  1.00 49.24  ? 340  GLN   A CG  1 
ATOM   522  C  CD  . GLN   A 1 77  ? -5.936  -51.369 -0.865  1.00 61.77  ? 340  GLN   A CD  1 
ATOM   523  O  OE1 . GLN   A 1 77  ? -6.581  -50.636 -0.113  1.00 69.98  ? 340  GLN   A OE1 1 
ATOM   524  N  NE2 . GLN   A 1 77  ? -4.823  -52.005 -0.515  1.00 65.96  ? 340  GLN   A NE2 1 
ATOM   525  N  N   . MET   A 1 78  ? -10.023 -49.951 -4.499  1.00 31.53  ? 341  MET   A N   1 
ATOM   526  C  CA  . MET   A 1 78  ? -10.820 -48.957 -5.266  1.00 34.59  ? 341  MET   A CA  1 
ATOM   527  C  C   . MET   A 1 78  ? -12.055 -48.524 -4.471  1.00 35.00  ? 341  MET   A C   1 
ATOM   528  O  O   . MET   A 1 78  ? -12.505 -47.390 -4.710  1.00 33.12  ? 341  MET   A O   1 
ATOM   529  C  CB  . MET   A 1 78  ? -11.293 -49.468 -6.629  1.00 35.79  ? 341  MET   A CB  1 
ATOM   530  C  CG  . MET   A 1 78  ? -10.182 -49.482 -7.660  1.00 41.74  ? 341  MET   A CG  1 
ATOM   531  S  SD  . MET   A 1 78  ? -10.762 -49.841 -9.346  1.00 44.05  ? 341  MET   A SD  1 
ATOM   532  C  CE  . MET   A 1 78  ? -12.135 -48.692 -9.366  1.00 36.85  ? 341  MET   A CE  1 
ATOM   533  N  N   . ALA   A 1 79  ? -12.619 -49.373 -3.591  1.00 34.27  ? 342  ALA   A N   1 
ATOM   534  C  CA  . ALA   A 1 79  ? -13.889 -49.027 -2.895  1.00 38.15  ? 342  ALA   A CA  1 
ATOM   535  C  C   . ALA   A 1 79  ? -13.654 -48.275 -1.574  1.00 36.64  ? 342  ALA   A C   1 
ATOM   536  O  O   . ALA   A 1 79  ? -14.636 -47.885 -0.978  1.00 37.65  ? 342  ALA   A O   1 
ATOM   537  C  CB  . ALA   A 1 79  ? -14.724 -50.283 -2.679  1.00 38.97  ? 342  ALA   A CB  1 
ATOM   538  N  N   . MET   A 1 80  ? -12.424 -48.105 -1.097  1.00 38.79  ? 343  MET   A N   1 
ATOM   539  C  CA  . MET   A 1 80  ? -12.171 -47.503 0.242   1.00 48.66  ? 343  MET   A CA  1 
ATOM   540  C  C   . MET   A 1 80  ? -12.132 -45.968 0.153   1.00 56.46  ? 343  MET   A C   1 
ATOM   541  O  O   . MET   A 1 80  ? -11.728 -45.458 -0.913  1.00 55.59  ? 343  MET   A O   1 
ATOM   542  C  CB  . MET   A 1 80  ? -10.836 -48.001 0.804   1.00 47.03  ? 343  MET   A CB  1 
ATOM   543  C  CG  . MET   A 1 80  ? -10.742 -49.521 0.890   1.00 51.41  ? 343  MET   A CG  1 
ATOM   544  S  SD  . MET   A 1 80  ? -11.962 -50.359 2.008   1.00 52.11  ? 343  MET   A SD  1 
ATOM   545  C  CE  . MET   A 1 80  ? -11.552 -49.620 3.595   1.00 47.38  ? 343  MET   A CE  1 
ATOM   546  N  N   . THR   A 1 81  ? -12.520 -45.270 1.239   1.00 74.16  ? 344  THR   A N   1 
ATOM   547  C  CA  . THR   A 1 81  ? -12.034 -43.911 1.601   1.00 73.74  ? 344  THR   A CA  1 
ATOM   548  C  C   . THR   A 1 81  ? -12.919 -42.795 1.081   1.00 70.05  ? 344  THR   A C   1 
ATOM   549  O  O   . THR   A 1 81  ? -14.149 -42.933 1.240   1.00 79.17  ? 344  THR   A O   1 
ATOM   550  N  N   . LYS   A 1 93  ? -7.813  -27.047 -3.401  0.50 107.22 ? 356  LYS   A N   1 
ATOM   551  C  CA  . LYS   A 1 93  ? -6.826  -28.095 -3.780  0.50 108.44 ? 356  LYS   A CA  1 
ATOM   552  C  C   . LYS   A 1 93  ? -5.485  -27.422 -4.107  0.50 109.05 ? 356  LYS   A C   1 
ATOM   553  O  O   . LYS   A 1 93  ? -5.492  -26.217 -4.431  0.50 109.95 ? 356  LYS   A O   1 
ATOM   554  C  CB  . LYS   A 1 93  ? -7.358  -28.919 -4.959  0.50 108.11 ? 356  LYS   A CB  1 
ATOM   555  C  CG  . LYS   A 1 93  ? -8.870  -29.112 -4.982  0.50 105.13 ? 356  LYS   A CG  1 
ATOM   556  C  CD  . LYS   A 1 93  ? -9.334  -30.259 -5.857  0.50 106.04 ? 356  LYS   A CD  1 
ATOM   557  C  CE  . LYS   A 1 93  ? -8.891  -30.134 -7.299  0.50 108.67 ? 356  LYS   A CE  1 
ATOM   558  N  NZ  . LYS   A 1 93  ? -9.379  -31.263 -8.127  0.50 108.15 ? 356  LYS   A NZ  1 
ATOM   559  N  N   . GLU   A 1 94  ? -4.382  -28.172 -4.017  0.50 107.99 ? 357  GLU   A N   1 
ATOM   560  C  CA  . GLU   A 1 94  ? -2.992  -27.671 -4.209  0.50 104.48 ? 357  GLU   A CA  1 
ATOM   561  C  C   . GLU   A 1 94  ? -2.694  -27.555 -5.708  0.50 99.08  ? 357  GLU   A C   1 
ATOM   562  O  O   . GLU   A 1 94  ? -1.533  -27.269 -6.062  0.50 91.23  ? 357  GLU   A O   1 
ATOM   563  C  CB  . GLU   A 1 94  ? -2.000  -28.607 -3.517  0.50 106.69 ? 357  GLU   A CB  1 
ATOM   564  C  CG  . GLU   A 1 94  ? -2.450  -29.043 -2.133  0.50 110.63 ? 357  GLU   A CG  1 
ATOM   565  C  CD  . GLU   A 1 94  ? -3.771  -29.798 -2.091  0.50 113.42 ? 357  GLU   A CD  1 
ATOM   566  O  OE1 . GLU   A 1 94  ? -4.509  -29.642 -1.095  0.50 114.08 ? 357  GLU   A OE1 1 
ATOM   567  O  OE2 . GLU   A 1 94  ? -4.058  -30.547 -3.049  0.50 114.94 ? 357  GLU   A OE2 1 
ATOM   568  N  N   . LYS   A 1 95  ? -3.713  -27.779 -6.545  0.50 96.51  ? 358  LYS   A N   1 
ATOM   569  C  CA  . LYS   A 1 95  ? -3.648  -27.662 -8.027  0.50 91.21  ? 358  LYS   A CA  1 
ATOM   570  C  C   . LYS   A 1 95  ? -4.389  -26.392 -8.459  0.50 87.14  ? 358  LYS   A C   1 
ATOM   571  O  O   . LYS   A 1 95  ? -3.897  -25.696 -9.370  0.50 81.41  ? 358  LYS   A O   1 
ATOM   572  C  CB  . LYS   A 1 95  ? -4.272  -28.898 -8.684  0.50 91.78  ? 358  LYS   A CB  1 
ATOM   573  C  CG  . LYS   A 1 95  ? -3.958  -29.077 -10.163 0.50 90.49  ? 358  LYS   A CG  1 
ATOM   574  C  CD  . LYS   A 1 95  ? -2.500  -29.380 -10.429 0.50 89.26  ? 358  LYS   A CD  1 
ATOM   575  C  CE  . LYS   A 1 95  ? -2.180  -29.524 -11.900 0.50 87.04  ? 358  LYS   A CE  1 
ATOM   576  N  NZ  . LYS   A 1 95  ? -0.812  -30.049 -12.111 0.50 85.67  ? 358  LYS   A NZ  1 
ATOM   577  N  N   . VAL   A 1 96  ? -5.524  -26.108 -7.809  0.50 85.15  ? 359  VAL   A N   1 
ATOM   578  C  CA  . VAL   A 1 96  ? -6.444  -24.976 -8.138  0.50 80.76  ? 359  VAL   A CA  1 
ATOM   579  C  C   . VAL   A 1 96  ? -5.799  -23.654 -7.690  0.50 74.09  ? 359  VAL   A C   1 
ATOM   580  O  O   . VAL   A 1 96  ? -5.957  -22.655 -8.413  0.50 70.38  ? 359  VAL   A O   1 
ATOM   581  C  CB  . VAL   A 1 96  ? -7.840  -25.190 -7.514  0.50 80.13  ? 359  VAL   A CB  1 
ATOM   582  C  CG1 . VAL   A 1 96  ? -7.776  -25.350 -6.001  0.50 81.44  ? 359  VAL   A CG1 1 
ATOM   583  C  CG2 . VAL   A 1 96  ? -8.811  -24.083 -7.893  0.50 77.48  ? 359  VAL   A CG2 1 
ATOM   584  N  N   . ASP   A 1 97  ? -5.080  -23.651 -6.561  0.50 69.91  ? 360  ASP   A N   1 
ATOM   585  C  CA  . ASP   A 1 97  ? -4.409  -22.441 -6.010  0.50 69.05  ? 360  ASP   A CA  1 
ATOM   586  C  C   . ASP   A 1 97  ? -3.048  -22.263 -6.706  0.50 70.75  ? 360  ASP   A C   1 
ATOM   587  O  O   . ASP   A 1 97  ? -2.054  -21.984 -6.003  0.50 70.89  ? 360  ASP   A O   1 
ATOM   588  C  CB  . ASP   A 1 97  ? -4.291  -22.520 -4.482  0.50 65.94  ? 360  ASP   A CB  1 
ATOM   589  C  CG  . ASP   A 1 97  ? -4.455  -21.193 -3.749  0.50 63.48  ? 360  ASP   A CG  1 
ATOM   590  O  OD1 . ASP   A 1 97  ? -4.337  -20.133 -4.395  0.50 60.49  ? 360  ASP   A OD1 1 
ATOM   591  O  OD2 . ASP   A 1 97  ? -4.706  -21.228 -2.528  0.50 63.07  ? 360  ASP   A OD2 1 
ATOM   592  N  N   . THR   A 1 98  ? -3.013  -22.414 -8.037  0.50 71.07  ? 361  THR   A N   1 
ATOM   593  C  CA  . THR   A 1 98  ? -1.841  -22.124 -8.914  0.50 71.65  ? 361  THR   A CA  1 
ATOM   594  C  C   . THR   A 1 98  ? -2.215  -20.998 -9.887  0.50 74.62  ? 361  THR   A C   1 
ATOM   595  O  O   . THR   A 1 98  ? -3.425  -20.750 -10.049 0.50 69.82  ? 361  THR   A O   1 
ATOM   596  C  CB  . THR   A 1 98  ? -1.369  -23.380 -9.661  0.50 70.60  ? 361  THR   A CB  1 
ATOM   597  O  OG1 . THR   A 1 98  ? -2.502  -23.995 -10.276 0.50 68.16  ? 361  THR   A OG1 1 
ATOM   598  C  CG2 . THR   A 1 98  ? -0.675  -24.380 -8.761  0.50 70.11  ? 361  THR   A CG2 1 
ATOM   599  N  N   . ARG   A 1 99  ? -1.221  -20.345 -10.504 0.50 81.51  ? 362  ARG   A N   1 
ATOM   600  C  CA  . ARG   A 1 99  ? -1.420  -19.199 -11.438 0.50 85.30  ? 362  ARG   A CA  1 
ATOM   601  C  C   . ARG   A 1 99  ? -0.621  -19.426 -12.730 0.50 87.22  ? 362  ARG   A C   1 
ATOM   602  O  O   . ARG   A 1 99  ? 0.625   -19.429 -12.659 0.50 92.09  ? 362  ARG   A O   1 
ATOM   603  C  CB  . ARG   A 1 99  ? -0.986  -17.884 -10.779 0.50 87.93  ? 362  ARG   A CB  1 
ATOM   604  C  CG  . ARG   A 1 99  ? -1.386  -16.639 -11.560 0.50 89.82  ? 362  ARG   A CG  1 
ATOM   605  C  CD  . ARG   A 1 99  ? -0.346  -15.532 -11.515 0.50 89.38  ? 362  ARG   A CD  1 
ATOM   606  N  NE  . ARG   A 1 99  ? 0.861   -15.867 -12.263 0.50 90.67  ? 362  ARG   A NE  1 
ATOM   607  C  CZ  . ARG   A 1 99  ? 1.611   -14.988 -12.922 0.50 85.79  ? 362  ARG   A CZ  1 
ATOM   608  N  NH1 . ARG   A 1 99  ? 1.271   -13.711 -12.939 0.50 83.98  ? 362  ARG   A NH1 1 
ATOM   609  N  NH2 . ARG   A 1 99  ? 2.691   -15.388 -13.572 0.50 84.02  ? 362  ARG   A NH2 1 
ATOM   610  N  N   . THR   A 1 100 ? -1.313  -19.582 -13.865 0.50 85.63  ? 363  THR   A N   1 
ATOM   611  C  CA  . THR   A 1 100 ? -0.711  -19.746 -15.218 0.50 82.05  ? 363  THR   A CA  1 
ATOM   612  C  C   . THR   A 1 100 ? -0.275  -18.379 -15.750 0.50 76.55  ? 363  THR   A C   1 
ATOM   613  O  O   . THR   A 1 100 ? -1.038  -17.417 -15.570 0.50 75.90  ? 363  THR   A O   1 
ATOM   614  C  CB  . THR   A 1 100 ? -1.690  -20.402 -16.198 0.50 85.18  ? 363  THR   A CB  1 
ATOM   615  O  OG1 . THR   A 1 100 ? -2.024  -21.695 -15.693 0.50 85.00  ? 363  THR   A OG1 1 
ATOM   616  C  CG2 . THR   A 1 100 ? -1.120  -20.531 -17.594 0.50 86.15  ? 363  THR   A CG2 1 
ATOM   617  N  N   . GLN   A 1 101 ? 0.898   -18.309 -16.387 0.50 74.21  ? 364  GLN   A N   1 
ATOM   618  C  CA  . GLN   A 1 101 ? 1.486   -17.047 -16.917 0.50 72.61  ? 364  GLN   A CA  1 
ATOM   619  C  C   . GLN   A 1 101 ? 0.652   -16.549 -18.105 0.50 68.57  ? 364  GLN   A C   1 
ATOM   620  O  O   . GLN   A 1 101 ? -0.381  -17.178 -18.415 0.50 69.04  ? 364  GLN   A O   1 
ATOM   621  C  CB  . GLN   A 1 101 ? 2.950   -17.247 -17.320 0.50 70.76  ? 364  GLN   A CB  1 
ATOM   622  C  CG  . GLN   A 1 101 ? 3.555   -16.024 -17.999 0.50 71.35  ? 364  GLN   A CG  1 
ATOM   623  C  CD  . GLN   A 1 101 ? 5.052   -16.118 -18.176 0.50 71.60  ? 364  GLN   A CD  1 
ATOM   624  O  OE1 . GLN   A 1 101 ? 5.649   -17.184 -18.044 0.50 69.34  ? 364  GLN   A OE1 1 
ATOM   625  N  NE2 . GLN   A 1 101 ? 5.674   -14.988 -18.475 0.50 70.35  ? 364  GLN   A NE2 1 
ATOM   626  N  N   . GLU   A 1 102 ? 1.086   -15.447 -18.725 0.50 64.33  ? 365  GLU   A N   1 
ATOM   627  C  CA  . GLU   A 1 102 ? 0.448   -14.833 -19.921 0.50 61.06  ? 365  GLU   A CA  1 
ATOM   628  C  C   . GLU   A 1 102 ? 1.245   -15.224 -21.160 0.50 55.09  ? 365  GLU   A C   1 
ATOM   629  O  O   . GLU   A 1 102 ? 2.439   -14.953 -21.253 0.50 52.90  ? 365  GLU   A O   1 
ATOM   630  C  CB  . GLU   A 1 102 ? 0.395   -13.310 -19.781 0.50 64.11  ? 365  GLU   A CB  1 
ATOM   631  C  CG  . GLU   A 1 102 ? -0.414  -12.617 -20.871 0.50 65.17  ? 365  GLU   A CG  1 
ATOM   632  C  CD  . GLU   A 1 102 ? -1.906  -12.534 -20.595 0.50 64.08  ? 365  GLU   A CD  1 
ATOM   633  O  OE1 . GLU   A 1 102 ? -2.623  -11.843 -21.357 0.50 64.70  ? 365  GLU   A OE1 1 
ATOM   634  O  OE2 . GLU   A 1 102 ? -2.346  -13.157 -19.612 0.50 64.13  ? 365  GLU   A OE2 1 
ATOM   635  N  N   . PRO   A 1 103 ? 0.610   -15.874 -22.157 0.50 51.35  ? 366  PRO   A N   1 
ATOM   636  C  CA  . PRO   A 1 103 ? 1.313   -16.248 -23.379 0.50 49.06  ? 366  PRO   A CA  1 
ATOM   637  C  C   . PRO   A 1 103 ? 1.999   -14.994 -23.930 0.50 48.10  ? 366  PRO   A C   1 
ATOM   638  O  O   . PRO   A 1 103 ? 1.631   -13.918 -23.510 0.50 46.97  ? 366  PRO   A O   1 
ATOM   639  C  CB  . PRO   A 1 103 ? 0.211   -16.774 -24.309 0.50 48.79  ? 366  PRO   A CB  1 
ATOM   640  C  CG  . PRO   A 1 103 ? -0.910  -17.181 -23.370 0.50 49.98  ? 366  PRO   A CG  1 
ATOM   641  C  CD  . PRO   A 1 103 ? -0.810  -16.252 -22.177 0.50 49.66  ? 366  PRO   A CD  1 
ATOM   642  N  N   . LYS   A 1 104 ? 2.961   -15.169 -24.837 0.50 48.25  ? 367  LYS   A N   1 
ATOM   643  C  CA  . LYS   A 1 104 ? 3.721   -14.066 -25.480 0.50 49.12  ? 367  LYS   A CA  1 
ATOM   644  C  C   . LYS   A 1 104 ? 3.020   -13.658 -26.782 0.50 50.37  ? 367  LYS   A C   1 
ATOM   645  O  O   . LYS   A 1 104 ? 2.256   -14.477 -27.336 0.50 47.57  ? 367  LYS   A O   1 
ATOM   646  C  CB  . LYS   A 1 104 ? 5.172   -14.501 -25.711 0.50 50.48  ? 367  LYS   A CB  1 
ATOM   647  C  CG  . LYS   A 1 104 ? 5.850   -15.114 -24.491 0.50 49.40  ? 367  LYS   A CG  1 
ATOM   648  C  CD  . LYS   A 1 104 ? 7.352   -15.103 -24.555 0.50 48.56  ? 367  LYS   A CD  1 
ATOM   649  C  CE  . LYS   A 1 104 ? 7.975   -15.579 -23.264 0.50 48.99  ? 367  LYS   A CE  1 
ATOM   650  N  NZ  . LYS   A 1 104 ? 7.320   -14.952 -22.092 0.50 48.55  ? 367  LYS   A NZ  1 
ATOM   651  N  N   . GLU   A 1 105 ? 3.282   -12.432 -27.241 0.50 53.33  ? 368  GLU   A N   1 
ATOM   652  C  CA  . GLU   A 1 105 ? 2.593   -11.771 -28.381 0.50 57.17  ? 368  GLU   A CA  1 
ATOM   653  C  C   . GLU   A 1 105 ? 2.323   -12.796 -29.488 0.50 54.07  ? 368  GLU   A C   1 
ATOM   654  O  O   . GLU   A 1 105 ? 1.170   -12.860 -29.960 0.50 53.60  ? 368  GLU   A O   1 
ATOM   655  C  CB  . GLU   A 1 105 ? 3.437   -10.612 -28.922 0.50 62.29  ? 368  GLU   A CB  1 
ATOM   656  C  CG  . GLU   A 1 105 ? 4.056   -9.741  -27.839 0.50 64.52  ? 368  GLU   A CG  1 
ATOM   657  C  CD  . GLU   A 1 105 ? 3.080   -9.224  -26.795 0.50 67.12  ? 368  GLU   A CD  1 
ATOM   658  O  OE1 . GLU   A 1 105 ? 1.885   -9.079  -27.121 0.50 69.66  ? 368  GLU   A OE1 1 
ATOM   659  O  OE2 . GLU   A 1 105 ? 3.518   -8.974  -25.654 0.50 69.44  ? 368  GLU   A OE2 1 
ATOM   660  N  N   . GLY   A 1 106 ? 3.355   -13.544 -29.890 1.00 51.86  ? 369  GLY   A N   1 
ATOM   661  C  CA  . GLY   A 1 106 ? 3.290   -14.457 -31.050 1.00 48.55  ? 369  GLY   A CA  1 
ATOM   662  C  C   . GLY   A 1 106 ? 2.385   -15.649 -30.741 1.00 47.07  ? 369  GLY   A C   1 
ATOM   663  O  O   . GLY   A 1 106 ? 1.612   -16.047 -31.638 1.00 50.83  ? 369  GLY   A O   1 
ATOM   664  N  N   . THR   A 1 107 ? 2.443   -16.177 -29.514 1.00 40.90  ? 370  THR   A N   1 
ATOM   665  C  CA  . THR   A 1 107 ? 1.513   -17.227 -29.026 1.00 48.14  ? 370  THR   A CA  1 
ATOM   666  C  C   . THR   A 1 107 ? 0.057   -16.728 -29.078 1.00 49.32  ? 370  THR   A C   1 
ATOM   667  O  O   . THR   A 1 107 ? -0.781  -17.410 -29.722 1.00 47.43  ? 370  THR   A O   1 
ATOM   668  C  CB  . THR   A 1 107 ? 1.909   -17.700 -27.630 1.00 47.49  ? 370  THR   A CB  1 
ATOM   669  O  OG1 . THR   A 1 107 ? 3.326   -17.868 -27.650 1.00 44.01  ? 370  THR   A OG1 1 
ATOM   670  C  CG2 . THR   A 1 107 ? 1.217   -18.996 -27.275 1.00 45.94  ? 370  THR   A CG2 1 
ATOM   671  N  N   . LYS   A 1 108 ? -0.236  -15.569 -28.485 1.00 51.51  ? 371  LYS   A N   1 
ATOM   672  C  CA  . LYS   A 1 108 ? -1.585  -14.909 -28.520 1.00 52.19  ? 371  LYS   A CA  1 
ATOM   673  C  C   . LYS   A 1 108 ? -2.125  -14.693 -29.952 1.00 46.44  ? 371  LYS   A C   1 
ATOM   674  O  O   . LYS   A 1 108 ? -3.330  -14.956 -30.163 1.00 43.64  ? 371  LYS   A O   1 
ATOM   675  C  CB  . LYS   A 1 108 ? -1.544  -13.600 -27.726 1.00 52.54  ? 371  LYS   A CB  1 
ATOM   676  C  CG  . LYS   A 1 108 ? -1.383  -13.814 -26.228 1.00 52.74  ? 371  LYS   A CG  1 
ATOM   677  C  CD  . LYS   A 1 108 ? -1.813  -12.646 -25.394 1.00 55.52  ? 371  LYS   A CD  1 
ATOM   678  C  CE  . LYS   A 1 108 ? -0.712  -11.633 -25.179 1.00 66.59  ? 371  LYS   A CE  1 
ATOM   679  N  NZ  . LYS   A 1 108 ? -0.841  -10.953 -23.866 1.00 75.70  ? 371  LYS   A NZ  1 
ATOM   680  N  N   . LYS   A 1 109 ? -1.284  -14.304 -30.911 1.00 42.17  ? 372  LYS   A N   1 
ATOM   681  C  CA  . LYS   A 1 109 ? -1.680  -14.101 -32.328 1.00 45.08  ? 372  LYS   A CA  1 
ATOM   682  C  C   . LYS   A 1 109 ? -2.060  -15.450 -32.970 1.00 49.41  ? 372  LYS   A C   1 
ATOM   683  O  O   . LYS   A 1 109 ? -3.117  -15.485 -33.674 1.00 42.90  ? 372  LYS   A O   1 
ATOM   684  C  CB  . LYS   A 1 109 ? -0.548  -13.397 -33.084 1.00 54.74  ? 372  LYS   A CB  1 
ATOM   685  C  CG  . LYS   A 1 109 ? -0.869  -12.898 -34.496 1.00 69.55  ? 372  LYS   A CG  1 
ATOM   686  C  CD  . LYS   A 1 109 ? -1.971  -11.833 -34.591 1.00 76.60  ? 372  LYS   A CD  1 
ATOM   687  C  CE  . LYS   A 1 109 ? -1.775  -10.661 -33.651 1.00 83.97  ? 372  LYS   A CE  1 
ATOM   688  N  NZ  . LYS   A 1 109 ? -2.670  -9.530  -33.992 1.00 80.59  ? 372  LYS   A NZ  1 
ATOM   689  N  N   . LEU   A 1 110 ? -1.203  -16.480 -32.796 1.00 49.46  ? 373  LEU   A N   1 
ATOM   690  C  CA  . LEU   A 1 110 ? -1.397  -17.878 -33.290 1.00 45.26  ? 373  LEU   A CA  1 
ATOM   691  C  C   . LEU   A 1 110 ? -2.765  -18.382 -32.809 1.00 37.13  ? 373  LEU   A C   1 
ATOM   692  O  O   . LEU   A 1 110 ? -3.509  -18.918 -33.632 1.00 35.69  ? 373  LEU   A O   1 
ATOM   693  C  CB  . LEU   A 1 110 ? -0.282  -18.793 -32.764 1.00 44.81  ? 373  LEU   A CB  1 
ATOM   694  C  CG  . LEU   A 1 110 ? 1.098   -18.620 -33.417 1.00 48.92  ? 373  LEU   A CG  1 
ATOM   695  C  CD1 . LEU   A 1 110 ? 2.195   -19.333 -32.618 1.00 43.35  ? 373  LEU   A CD1 1 
ATOM   696  C  CD2 . LEU   A 1 110 ? 1.070   -19.110 -34.868 1.00 48.74  ? 373  LEU   A CD2 1 
ATOM   697  N  N   . MET   A 1 111 ? -3.060  -18.206 -31.527 1.00 31.69  ? 374  MET   A N   1 
ATOM   698  C  CA  . MET   A 1 111 ? -4.318  -18.672 -30.878 1.00 37.63  ? 374  MET   A CA  1 
ATOM   699  C  C   . MET   A 1 111 ? -5.535  -17.908 -31.434 1.00 40.72  ? 374  MET   A C   1 
ATOM   700  O  O   . MET   A 1 111 ? -6.543  -18.588 -31.762 1.00 38.89  ? 374  MET   A O   1 
ATOM   701  C  CB  . MET   A 1 111 ? -4.269  -18.529 -29.346 1.00 36.00  ? 374  MET   A CB  1 
ATOM   702  C  CG  . MET   A 1 111 ? -3.199  -19.429 -28.719 1.00 36.77  ? 374  MET   A CG  1 
ATOM   703  S  SD  . MET   A 1 111 ? -3.330  -19.693 -26.940 1.00 42.26  ? 374  MET   A SD  1 
ATOM   704  C  CE  . MET   A 1 111 ? -3.106  -18.056 -26.258 1.00 42.80  ? 374  MET   A CE  1 
ATOM   705  N  N   . LYS   A 1 112 ? -5.470  -16.572 -31.521 1.00 36.94  ? 375  LYS   A N   1 
ATOM   706  C  CA  . LYS   A 1 112 ? -6.584  -15.727 -32.030 1.00 41.27  ? 375  LYS   A CA  1 
ATOM   707  C  C   . LYS   A 1 112 ? -6.851  -16.116 -33.491 1.00 40.77  ? 375  LYS   A C   1 
ATOM   708  O  O   . LYS   A 1 112 ? -8.011  -16.343 -33.828 1.00 38.73  ? 375  LYS   A O   1 
ATOM   709  C  CB  . LYS   A 1 112 ? -6.249  -14.227 -31.928 1.00 50.47  ? 375  LYS   A CB  1 
ATOM   710  C  CG  . LYS   A 1 112 ? -7.323  -13.304 -31.345 1.00 57.72  ? 375  LYS   A CG  1 
ATOM   711  C  CD  . LYS   A 1 112 ? -7.213  -13.099 -29.814 1.00 66.09  ? 375  LYS   A CD  1 
ATOM   712  C  CE  . LYS   A 1 112 ? -8.497  -12.645 -29.131 1.00 73.81  ? 375  LYS   A CE  1 
ATOM   713  N  NZ  . LYS   A 1 112 ? -8.464  -12.876 -27.662 1.00 71.00  ? 375  LYS   A NZ  1 
ATOM   714  N  N   . ILE   A 1 113 ? -5.817  -16.226 -34.329 1.00 37.65  ? 376  ILE   A N   1 
ATOM   715  C  CA  . ILE   A 1 113 ? -6.016  -16.571 -35.762 1.00 39.53  ? 376  ILE   A CA  1 
ATOM   716  C  C   . ILE   A 1 113 ? -6.631  -17.965 -35.869 1.00 40.69  ? 376  ILE   A C   1 
ATOM   717  O  O   . ILE   A 1 113 ? -7.494  -18.153 -36.777 1.00 37.67  ? 376  ILE   A O   1 
ATOM   718  C  CB  . ILE   A 1 113 ? -4.722  -16.513 -36.586 1.00 42.06  ? 376  ILE   A CB  1 
ATOM   719  C  CG1 . ILE   A 1 113 ? -4.213  -15.080 -36.755 1.00 54.41  ? 376  ILE   A CG1 1 
ATOM   720  C  CG2 . ILE   A 1 113 ? -4.907  -17.159 -37.943 1.00 40.62  ? 376  ILE   A CG2 1 
ATOM   721  C  CD1 . ILE   A 1 113 ? -2.784  -15.003 -37.247 1.00 57.42  ? 376  ILE   A CD1 1 
ATOM   722  N  N   . THR   A 1 114 ? -6.122  -18.925 -35.083 1.00 37.92  ? 377  THR   A N   1 
ATOM   723  C  CA  . THR   A 1 114 ? -6.561  -20.347 -35.146 1.00 34.63  ? 377  THR   A CA  1 
ATOM   724  C  C   . THR   A 1 114 ? -8.006  -20.459 -34.642 1.00 33.93  ? 377  THR   A C   1 
ATOM   725  O  O   . THR   A 1 114 ? -8.827  -21.146 -35.303 1.00 29.87  ? 377  THR   A O   1 
ATOM   726  C  CB  . THR   A 1 114 ? -5.624  -21.269 -34.369 1.00 32.93  ? 377  THR   A CB  1 
ATOM   727  O  OG1 . THR   A 1 114 ? -4.316  -21.055 -34.892 1.00 33.51  ? 377  THR   A OG1 1 
ATOM   728  C  CG2 . THR   A 1 114 ? -6.006  -22.717 -34.538 1.00 34.20  ? 377  THR   A CG2 1 
ATOM   729  N  N   . ALA   A 1 115 ? -8.307  -19.792 -33.527 1.00 37.31  ? 378  ALA   A N   1 
ATOM   730  C  CA  . ALA   A 1 115 ? -9.634  -19.821 -32.874 1.00 37.50  ? 378  ALA   A CA  1 
ATOM   731  C  C   . ALA   A 1 115 ? -10.699 -19.230 -33.817 1.00 40.51  ? 378  ALA   A C   1 
ATOM   732  O  O   . ALA   A 1 115 ? -11.774 -19.875 -34.037 1.00 40.18  ? 378  ALA   A O   1 
ATOM   733  C  CB  . ALA   A 1 115 ? -9.561  -19.078 -31.577 1.00 37.03  ? 378  ALA   A CB  1 
ATOM   734  N  N   . GLU   A 1 116 ? -10.396 -18.078 -34.410 1.00 38.86  ? 379  GLU   A N   1 
ATOM   735  C  CA  . GLU   A 1 116 ? -11.287 -17.412 -35.392 1.00 42.67  ? 379  GLU   A CA  1 
ATOM   736  C  C   . GLU   A 1 116 ? -11.606 -18.405 -36.521 1.00 39.65  ? 379  GLU   A C   1 
ATOM   737  O  O   . GLU   A 1 116 ? -12.787 -18.579 -36.866 1.00 38.82  ? 379  GLU   A O   1 
ATOM   738  C  CB  . GLU   A 1 116 ? -10.637 -16.128 -35.903 1.00 43.66  ? 379  GLU   A CB  1 
ATOM   739  C  CG  . GLU   A 1 116 ? -11.433 -15.456 -37.007 1.00 52.69  ? 379  GLU   A CG  1 
ATOM   740  C  CD  . GLU   A 1 116 ? -10.867 -14.140 -37.525 1.00 61.23  ? 379  GLU   A CD  1 
ATOM   741  O  OE1 . GLU   A 1 116 ? -9.633  -14.094 -37.808 1.00 62.68  ? 379  GLU   A OE1 1 
ATOM   742  O  OE2 . GLU   A 1 116 ? -11.660 -13.168 -37.644 1.00 69.65  ? 379  GLU   A OE2 1 
ATOM   743  N  N   . TRP   A 1 117 ? -10.595 -19.039 -37.091 1.00 34.15  ? 380  TRP   A N   1 
ATOM   744  C  CA  . TRP   A 1 117 ? -10.765 -19.992 -38.213 1.00 34.62  ? 380  TRP   A CA  1 
ATOM   745  C  C   . TRP   A 1 117 ? -11.530 -21.242 -37.742 1.00 38.08  ? 380  TRP   A C   1 
ATOM   746  O  O   . TRP   A 1 117 ? -12.277 -21.840 -38.562 1.00 35.53  ? 380  TRP   A O   1 
ATOM   747  C  CB  . TRP   A 1 117 ? -9.391  -20.341 -38.768 1.00 34.91  ? 380  TRP   A CB  1 
ATOM   748  C  CG  . TRP   A 1 117 ? -9.433  -21.440 -39.768 1.00 31.18  ? 380  TRP   A CG  1 
ATOM   749  C  CD1 . TRP   A 1 117 ? -9.558  -21.302 -41.105 1.00 32.53  ? 380  TRP   A CD1 1 
ATOM   750  C  CD2 . TRP   A 1 117 ? -9.398  -22.848 -39.508 1.00 33.51  ? 380  TRP   A CD2 1 
ATOM   751  N  NE1 . TRP   A 1 117 ? -9.545  -22.524 -41.706 1.00 35.78  ? 380  TRP   A NE1 1 
ATOM   752  C  CE2 . TRP   A 1 117 ? -9.471  -23.498 -40.749 1.00 34.69  ? 380  TRP   A CE2 1 
ATOM   753  C  CE3 . TRP   A 1 117 ? -9.285  -23.630 -38.357 1.00 35.44  ? 380  TRP   A CE3 1 
ATOM   754  C  CZ2 . TRP   A 1 117 ? -9.443  -24.888 -40.874 1.00 37.89  ? 380  TRP   A CZ2 1 
ATOM   755  C  CZ3 . TRP   A 1 117 ? -9.219  -24.998 -38.483 1.00 33.45  ? 380  TRP   A CZ3 1 
ATOM   756  C  CH2 . TRP   A 1 117 ? -9.328  -25.622 -39.717 1.00 33.17  ? 380  TRP   A CH2 1 
ATOM   757  N  N   . LEU   A 1 118 ? -11.344 -21.669 -36.488 1.00 38.25  ? 381  LEU   A N   1 
ATOM   758  C  CA  . LEU   A 1 118 ? -11.925 -22.961 -36.035 1.00 34.48  ? 381  LEU   A CA  1 
ATOM   759  C  C   . LEU   A 1 118 ? -13.431 -22.776 -35.811 1.00 33.35  ? 381  LEU   A C   1 
ATOM   760  O  O   . LEU   A 1 118 ? -14.169 -23.616 -36.314 1.00 28.88  ? 381  LEU   A O   1 
ATOM   761  C  CB  . LEU   A 1 118 ? -11.213 -23.473 -34.785 1.00 34.43  ? 381  LEU   A CB  1 
ATOM   762  C  CG  . LEU   A 1 118 ? -11.643 -24.876 -34.356 1.00 39.03  ? 381  LEU   A CG  1 
ATOM   763  C  CD1 . LEU   A 1 118 ? -11.491 -25.896 -35.491 1.00 37.15  ? 381  LEU   A CD1 1 
ATOM   764  C  CD2 . LEU   A 1 118 ? -10.883 -25.301 -33.111 1.00 38.79  ? 381  LEU   A CD2 1 
ATOM   765  N  N   . TRP   A 1 119 ? -13.859 -21.702 -35.136 1.00 32.12  ? 382  TRP   A N   1 
ATOM   766  C  CA  . TRP   A 1 119 ? -15.303 -21.360 -34.983 1.00 35.46  ? 382  TRP   A CA  1 
ATOM   767  C  C   . TRP   A 1 119 ? -15.999 -21.217 -36.351 1.00 37.68  ? 382  TRP   A C   1 
ATOM   768  O  O   . TRP   A 1 119 ? -17.121 -21.820 -36.530 1.00 40.36  ? 382  TRP   A O   1 
ATOM   769  C  CB  . TRP   A 1 119 ? -15.484 -20.110 -34.139 1.00 32.68  ? 382  TRP   A CB  1 
ATOM   770  C  CG  . TRP   A 1 119 ? -15.297 -20.329 -32.676 1.00 30.52  ? 382  TRP   A CG  1 
ATOM   771  C  CD1 . TRP   A 1 119 ? -14.517 -19.580 -31.856 1.00 32.12  ? 382  TRP   A CD1 1 
ATOM   772  C  CD2 . TRP   A 1 119 ? -15.951 -21.296 -31.831 1.00 33.15  ? 382  TRP   A CD2 1 
ATOM   773  N  NE1 . TRP   A 1 119 ? -14.644 -19.994 -30.561 1.00 32.82  ? 382  TRP   A NE1 1 
ATOM   774  C  CE2 . TRP   A 1 119 ? -15.506 -21.057 -30.516 1.00 33.19  ? 382  TRP   A CE2 1 
ATOM   775  C  CE3 . TRP   A 1 119 ? -16.881 -22.325 -32.044 1.00 32.68  ? 382  TRP   A CE3 1 
ATOM   776  C  CZ2 . TRP   A 1 119 ? -15.907 -21.845 -29.441 1.00 33.06  ? 382  TRP   A CZ2 1 
ATOM   777  C  CZ3 . TRP   A 1 119 ? -17.302 -23.082 -30.976 1.00 30.29  ? 382  TRP   A CZ3 1 
ATOM   778  C  CH2 . TRP   A 1 119 ? -16.807 -22.852 -29.697 1.00 30.69  ? 382  TRP   A CH2 1 
ATOM   779  N  N   . LYS   A 1 120 ? -15.364 -20.537 -37.316 1.00 36.16  ? 383  LYS   A N   1 
ATOM   780  C  CA  . LYS   A 1 120 ? -15.895 -20.482 -38.703 1.00 40.23  ? 383  LYS   A CA  1 
ATOM   781  C  C   . LYS   A 1 120 ? -16.093 -21.906 -39.213 1.00 38.35  ? 383  LYS   A C   1 
ATOM   782  O  O   . LYS   A 1 120 ? -17.203 -22.228 -39.649 1.00 39.72  ? 383  LYS   A O   1 
ATOM   783  C  CB  . LYS   A 1 120 ? -15.023 -19.657 -39.659 1.00 52.23  ? 383  LYS   A CB  1 
ATOM   784  C  CG  . LYS   A 1 120 ? -15.316 -18.161 -39.636 1.00 63.70  ? 383  LYS   A CG  1 
ATOM   785  C  CD  . LYS   A 1 120 ? -14.381 -17.297 -40.444 1.00 74.76  ? 383  LYS   A CD  1 
ATOM   786  C  CE  . LYS   A 1 120 ? -14.275 -15.897 -39.874 1.00 80.78  ? 383  LYS   A CE  1 
ATOM   787  N  NZ  . LYS   A 1 120 ? -13.008 -15.245 -40.285 1.00 88.27  ? 383  LYS   A NZ  1 
ATOM   788  N  N   . GLU   A 1 121 ? -15.072 -22.754 -39.172 1.00 37.88  ? 384  GLU   A N   1 
ATOM   789  C  CA  . GLU   A 1 121 ? -15.216 -24.125 -39.707 1.00 37.81  ? 384  GLU   A CA  1 
ATOM   790  C  C   . GLU   A 1 121 ? -16.339 -24.847 -38.978 1.00 35.07  ? 384  GLU   A C   1 
ATOM   791  O  O   . GLU   A 1 121 ? -17.082 -25.552 -39.671 1.00 40.25  ? 384  GLU   A O   1 
ATOM   792  C  CB  . GLU   A 1 121 ? -13.992 -24.992 -39.476 1.00 43.55  ? 384  GLU   A CB  1 
ATOM   793  C  CG  . GLU   A 1 121 ? -12.896 -24.680 -40.414 1.00 46.11  ? 384  GLU   A CG  1 
ATOM   794  C  CD  . GLU   A 1 121 ? -13.229 -24.878 -41.872 1.00 47.09  ? 384  GLU   A CD  1 
ATOM   795  O  OE1 . GLU   A 1 121 ? -13.602 -25.997 -42.269 1.00 46.14  ? 384  GLU   A OE1 1 
ATOM   796  O  OE2 . GLU   A 1 121 ? -13.043 -23.912 -42.599 1.00 47.84  ? 384  GLU   A OE2 1 
ATOM   797  N  N   . LEU   A 1 122 ? -16.444 -24.716 -37.645 1.00 32.89  ? 385  LEU   A N   1 
ATOM   798  C  CA  . LEU   A 1 122 ? -17.444 -25.516 -36.865 1.00 33.68  ? 385  LEU   A CA  1 
ATOM   799  C  C   . LEU   A 1 122 ? -18.848 -25.005 -37.219 1.00 35.30  ? 385  LEU   A C   1 
ATOM   800  O  O   . LEU   A 1 122 ? -19.801 -25.806 -37.228 1.00 36.35  ? 385  LEU   A O   1 
ATOM   801  C  CB  . LEU   A 1 122 ? -17.165 -25.418 -35.360 1.00 29.52  ? 385  LEU   A CB  1 
ATOM   802  C  CG  . LEU   A 1 122 ? -15.910 -26.149 -34.881 1.00 32.15  ? 385  LEU   A CG  1 
ATOM   803  C  CD1 . LEU   A 1 122 ? -15.613 -25.887 -33.420 1.00 28.71  ? 385  LEU   A CD1 1 
ATOM   804  C  CD2 . LEU   A 1 122 ? -16.054 -27.636 -35.106 1.00 31.78  ? 385  LEU   A CD2 1 
ATOM   805  N  N   . GLY   A 1 123 ? -18.938 -23.710 -37.520 1.00 37.86  ? 386  GLY   A N   1 
ATOM   806  C  CA  . GLY   A 1 123 ? -20.190 -22.999 -37.813 1.00 40.96  ? 386  GLY   A CA  1 
ATOM   807  C  C   . GLY   A 1 123 ? -20.646 -23.152 -39.250 1.00 43.11  ? 386  GLY   A C   1 
ATOM   808  O  O   . GLY   A 1 123 ? -21.779 -22.764 -39.498 1.00 47.93  ? 386  GLY   A O   1 
ATOM   809  N  N   . LYS   A 1 124 ? -19.845 -23.711 -40.162 1.00 39.61  ? 387  LYS   A N   1 
ATOM   810  C  CA  . LYS   A 1 124 ? -20.220 -23.755 -41.597 1.00 42.56  ? 387  LYS   A CA  1 
ATOM   811  C  C   . LYS   A 1 124 ? -21.515 -24.537 -41.818 1.00 44.86  ? 387  LYS   A C   1 
ATOM   812  O  O   . LYS   A 1 124 ? -22.197 -24.189 -42.744 1.00 46.09  ? 387  LYS   A O   1 
ATOM   813  C  CB  . LYS   A 1 124 ? -19.164 -24.388 -42.497 1.00 42.98  ? 387  LYS   A CB  1 
ATOM   814  C  CG  . LYS   A 1 124 ? -18.016 -23.459 -42.894 1.00 48.61  ? 387  LYS   A CG  1 
ATOM   815  C  CD  . LYS   A 1 124 ? -17.166 -24.034 -44.012 1.00 52.97  ? 387  LYS   A CD  1 
ATOM   816  C  CE  . LYS   A 1 124 ? -15.737 -23.529 -44.054 1.00 55.58  ? 387  LYS   A CE  1 
ATOM   817  N  NZ  . LYS   A 1 124 ? -14.901 -24.451 -44.867 1.00 60.94  ? 387  LYS   A NZ  1 
ATOM   818  N  N   . LYS   A 1 125 ? -21.782 -25.600 -41.065 1.00 42.05  ? 388  LYS   A N   1 
ATOM   819  C  CA  . LYS   A 1 125 ? -22.945 -26.491 -41.294 1.00 42.91  ? 388  LYS   A CA  1 
ATOM   820  C  C   . LYS   A 1 125 ? -23.826 -26.556 -40.038 1.00 38.07  ? 388  LYS   A C   1 
ATOM   821  O  O   . LYS   A 1 125 ? -24.630 -27.482 -39.937 1.00 43.57  ? 388  LYS   A O   1 
ATOM   822  C  CB  . LYS   A 1 125 ? -22.437 -27.868 -41.705 1.00 45.52  ? 388  LYS   A CB  1 
ATOM   823  C  CG  . LYS   A 1 125 ? -21.741 -27.893 -43.053 1.00 53.83  ? 388  LYS   A CG  1 
ATOM   824  C  CD  . LYS   A 1 125 ? -21.296 -29.295 -43.452 1.00 58.57  ? 388  LYS   A CD  1 
ATOM   825  C  CE  . LYS   A 1 125 ? -20.172 -29.821 -42.577 1.00 67.77  ? 388  LYS   A CE  1 
ATOM   826  N  NZ  . LYS   A 1 125 ? -20.368 -31.248 -42.207 1.00 69.90  ? 388  LYS   A NZ  1 
ATOM   827  N  N   . LYS   A 1 126 ? -23.676 -25.603 -39.120 1.00 36.08  ? 389  LYS   A N   1 
ATOM   828  C  CA  . LYS   A 1 126 ? -24.441 -25.533 -37.860 1.00 38.81  ? 389  LYS   A CA  1 
ATOM   829  C  C   . LYS   A 1 126 ? -24.863 -24.086 -37.630 1.00 42.74  ? 389  LYS   A C   1 
ATOM   830  O  O   . LYS   A 1 126 ? -24.096 -23.190 -37.981 1.00 44.14  ? 389  LYS   A O   1 
ATOM   831  C  CB  . LYS   A 1 126 ? -23.612 -25.939 -36.638 1.00 39.75  ? 389  LYS   A CB  1 
ATOM   832  C  CG  . LYS   A 1 126 ? -22.997 -27.321 -36.701 1.00 37.37  ? 389  LYS   A CG  1 
ATOM   833  C  CD  . LYS   A 1 126 ? -23.930 -28.386 -36.209 1.00 39.69  ? 389  LYS   A CD  1 
ATOM   834  C  CE  . LYS   A 1 126 ? -23.308 -29.756 -36.322 1.00 38.40  ? 389  LYS   A CE  1 
ATOM   835  N  NZ  . LYS   A 1 126 ? -24.351 -30.781 -36.392 1.00 37.88  ? 389  LYS   A NZ  1 
ATOM   836  N  N   . THR   A 1 127 ? -26.013 -23.908 -36.968 1.00 43.57  ? 390  THR   A N   1 
ATOM   837  C  CA  . THR   A 1 127 ? -26.628 -22.608 -36.627 1.00 42.15  ? 390  THR   A CA  1 
ATOM   838  C  C   . THR   A 1 127 ? -26.691 -22.496 -35.118 1.00 33.92  ? 390  THR   A C   1 
ATOM   839  O  O   . THR   A 1 127 ? -27.501 -23.166 -34.488 1.00 39.15  ? 390  THR   A O   1 
ATOM   840  C  CB  . THR   A 1 127 ? -28.077 -22.519 -37.142 1.00 50.83  ? 390  THR   A CB  1 
ATOM   841  O  OG1 . THR   A 1 127 ? -28.015 -22.592 -38.562 1.00 45.20  ? 390  THR   A OG1 1 
ATOM   842  C  CG2 . THR   A 1 127 ? -28.797 -21.267 -36.685 1.00 51.12  ? 390  THR   A CG2 1 
ATOM   843  N  N   . PRO   A 1 128 ? -25.920 -21.588 -34.501 1.00 34.73  ? 391  PRO   A N   1 
ATOM   844  C  CA  . PRO   A 1 128 ? -26.078 -21.356 -33.069 1.00 35.33  ? 391  PRO   A CA  1 
ATOM   845  C  C   . PRO   A 1 128 ? -27.567 -21.057 -32.781 1.00 40.20  ? 391  PRO   A C   1 
ATOM   846  O  O   . PRO   A 1 128 ? -28.251 -20.455 -33.608 1.00 41.32  ? 391  PRO   A O   1 
ATOM   847  C  CB  . PRO   A 1 128 ? -25.170 -20.156 -32.784 1.00 33.57  ? 391  PRO   A CB  1 
ATOM   848  C  CG  . PRO   A 1 128 ? -24.215 -20.101 -33.955 1.00 33.83  ? 391  PRO   A CG  1 
ATOM   849  C  CD  . PRO   A 1 128 ? -24.919 -20.722 -35.140 1.00 32.09  ? 391  PRO   A CD  1 
ATOM   850  N  N   . ARG   A 1 129 ? -28.074 -21.499 -31.641 1.00 40.52  ? 392  ARG   A N   1 
ATOM   851  C  CA  . ARG   A 1 129 ? -29.475 -21.198 -31.247 1.00 41.83  ? 392  ARG   A CA  1 
ATOM   852  C  C   . ARG   A 1 129 ? -29.597 -21.359 -29.742 1.00 45.18  ? 392  ARG   A C   1 
ATOM   853  O  O   . ARG   A 1 129 ? -28.786 -22.098 -29.135 1.00 40.69  ? 392  ARG   A O   1 
ATOM   854  C  CB  . ARG   A 1 129 ? -30.444 -22.088 -32.023 1.00 43.10  ? 392  ARG   A CB  1 
ATOM   855  C  CG  . ARG   A 1 129 ? -30.130 -23.573 -31.980 1.00 41.73  ? 392  ARG   A CG  1 
ATOM   856  C  CD  . ARG   A 1 129 ? -30.973 -24.235 -30.939 1.00 41.32  ? 392  ARG   A CD  1 
ATOM   857  N  NE  . ARG   A 1 129 ? -30.752 -25.667 -30.772 1.00 40.52  ? 392  ARG   A NE  1 
ATOM   858  C  CZ  . ARG   A 1 129 ? -31.296 -26.369 -29.787 1.00 39.12  ? 392  ARG   A CZ  1 
ATOM   859  N  NH1 . ARG   A 1 129 ? -32.126 -25.774 -28.955 1.00 42.11  ? 392  ARG   A NH1 1 
ATOM   860  N  NH2 . ARG   A 1 129 ? -31.060 -27.657 -29.653 1.00 40.54  ? 392  ARG   A NH2 1 
ATOM   861  N  N   . MET   A 1 130 ? -30.574 -20.676 -29.140 0.50 45.28  ? 393  MET   A N   1 
ATOM   862  C  CA  . MET   A 1 130 ? -30.849 -20.768 -27.685 0.50 46.00  ? 393  MET   A CA  1 
ATOM   863  C  C   . MET   A 1 130 ? -31.540 -22.103 -27.400 0.50 43.53  ? 393  MET   A C   1 
ATOM   864  O  O   . MET   A 1 130 ? -32.347 -22.540 -28.237 0.50 44.58  ? 393  MET   A O   1 
ATOM   865  C  CB  . MET   A 1 130 ? -31.718 -19.604 -27.205 0.50 50.02  ? 393  MET   A CB  1 
ATOM   866  C  CG  . MET   A 1 130 ? -30.911 -18.349 -26.940 0.50 52.42  ? 393  MET   A CG  1 
ATOM   867  S  SD  . MET   A 1 130 ? -31.924 -16.871 -26.686 0.50 57.96  ? 393  MET   A SD  1 
ATOM   868  C  CE  . MET   A 1 130 ? -32.997 -17.446 -25.370 0.50 57.15  ? 393  MET   A CE  1 
ATOM   869  N  N   . CYS   A 1 131 ? -31.189 -22.735 -26.280 1.00 41.73  ? 394  CYS   A N   1 
ATOM   870  C  CA  . CYS   A 1 131 ? -31.867 -23.945 -25.777 1.00 43.81  ? 394  CYS   A CA  1 
ATOM   871  C  C   . CYS   A 1 131 ? -33.025 -23.459 -24.872 1.00 47.94  ? 394  CYS   A C   1 
ATOM   872  O  O   . CYS   A 1 131 ? -33.001 -22.260 -24.425 1.00 52.79  ? 394  CYS   A O   1 
ATOM   873  C  CB  . CYS   A 1 131 ? -30.866 -24.881 -25.110 1.00 43.98  ? 394  CYS   A CB  1 
ATOM   874  S  SG  . CYS   A 1 131 ? -29.757 -25.715 -26.275 1.00 45.92  ? 394  CYS   A SG  1 
ATOM   875  N  N   . THR   A 1 132 ? -34.032 -24.306 -24.643 1.00 48.02  ? 395  THR   A N   1 
ATOM   876  C  CA  . THR   A 1 132 ? -35.378 -23.900 -24.123 1.00 51.70  ? 395  THR   A CA  1 
ATOM   877  C  C   . THR   A 1 132 ? -35.671 -24.494 -22.742 1.00 48.27  ? 395  THR   A C   1 
ATOM   878  O  O   . THR   A 1 132 ? -35.223 -25.625 -22.476 1.00 45.71  ? 395  THR   A O   1 
ATOM   879  C  CB  . THR   A 1 132 ? -36.486 -24.347 -25.087 1.00 48.24  ? 395  THR   A CB  1 
ATOM   880  O  OG1 . THR   A 1 132 ? -36.495 -25.776 -25.161 1.00 48.41  ? 395  THR   A OG1 1 
ATOM   881  C  CG2 . THR   A 1 132 ? -36.315 -23.772 -26.477 1.00 50.13  ? 395  THR   A CG2 1 
ATOM   882  N  N   . ARG   A 1 133 ? -36.452 -23.769 -21.928 1.00 58.61  ? 396  ARG   A N   1 
ATOM   883  C  CA  . ARG   A 1 133 ? -37.049 -24.271 -20.656 1.00 57.81  ? 396  ARG   A CA  1 
ATOM   884  C  C   . ARG   A 1 133 ? -37.558 -25.690 -20.894 1.00 58.98  ? 396  ARG   A C   1 
ATOM   885  O  O   . ARG   A 1 133 ? -37.257 -26.591 -20.093 1.00 63.22  ? 396  ARG   A O   1 
ATOM   886  C  CB  . ARG   A 1 133 ? -38.201 -23.385 -20.174 1.00 67.69  ? 396  ARG   A CB  1 
ATOM   887  C  CG  . ARG   A 1 133 ? -37.857 -21.904 -20.174 1.00 79.91  ? 396  ARG   A CG  1 
ATOM   888  C  CD  . ARG   A 1 133 ? -38.570 -21.051 -19.144 1.00 86.77  ? 396  ARG   A CD  1 
ATOM   889  N  NE  . ARG   A 1 133 ? -37.836 -19.808 -18.921 1.00 85.39  ? 396  ARG   A NE  1 
ATOM   890  C  CZ  . ARG   A 1 133 ? -38.272 -18.785 -18.187 1.00 92.58  ? 396  ARG   A CZ  1 
ATOM   891  N  NH1 . ARG   A 1 133 ? -39.472 -18.827 -17.625 1.00 93.14  ? 396  ARG   A NH1 1 
ATOM   892  N  NH2 . ARG   A 1 133 ? -37.509 -17.711 -18.043 1.00 84.45  ? 396  ARG   A NH2 1 
ATOM   893  N  N   . GLU   A 1 134 ? -38.267 -25.878 -22.001 1.00 61.42  ? 397  GLU   A N   1 
ATOM   894  C  CA  . GLU   A 1 134 ? -38.898 -27.165 -22.359 1.00 59.06  ? 397  GLU   A CA  1 
ATOM   895  C  C   . GLU   A 1 134 ? -37.793 -28.217 -22.429 1.00 57.53  ? 397  GLU   A C   1 
ATOM   896  O  O   . GLU   A 1 134 ? -37.905 -29.217 -21.743 1.00 65.29  ? 397  GLU   A O   1 
ATOM   897  C  CB  . GLU   A 1 134 ? -39.735 -26.996 -23.629 1.00 69.97  ? 397  GLU   A CB  1 
ATOM   898  C  CG  . GLU   A 1 134 ? -40.950 -26.086 -23.446 1.00 80.10  ? 397  GLU   A CG  1 
ATOM   899  C  CD  . GLU   A 1 134 ? -40.771 -24.566 -23.540 1.00 87.75  ? 397  GLU   A CD  1 
ATOM   900  O  OE1 . GLU   A 1 134 ? -39.693 -24.089 -23.981 1.00 76.01  ? 397  GLU   A OE1 1 
ATOM   901  O  OE2 . GLU   A 1 134 ? -41.731 -23.842 -23.182 1.00 89.07  ? 397  GLU   A OE2 1 
ATOM   902  N  N   . GLU   A 1 135 ? -36.742 -27.963 -23.211 0.50 60.34  ? 398  GLU   A N   1 
ATOM   903  C  CA  . GLU   A 1 135 ? -35.612 -28.922 -23.336 0.50 58.61  ? 398  GLU   A CA  1 
ATOM   904  C  C   . GLU   A 1 135 ? -35.008 -29.191 -21.957 0.50 59.79  ? 398  GLU   A C   1 
ATOM   905  O  O   . GLU   A 1 135 ? -34.764 -30.370 -21.640 0.50 57.34  ? 398  GLU   A O   1 
ATOM   906  C  CB  . GLU   A 1 135 ? -34.524 -28.356 -24.249 0.50 56.04  ? 398  GLU   A CB  1 
ATOM   907  C  CG  . GLU   A 1 135 ? -34.835 -28.468 -25.728 0.50 54.73  ? 398  GLU   A CG  1 
ATOM   908  C  CD  . GLU   A 1 135 ? -33.750 -27.894 -26.622 0.50 51.57  ? 398  GLU   A CD  1 
ATOM   909  O  OE1 . GLU   A 1 135 ? -33.361 -26.733 -26.402 0.50 46.12  ? 398  GLU   A OE1 1 
ATOM   910  O  OE2 . GLU   A 1 135 ? -33.286 -28.615 -27.523 0.50 47.94  ? 398  GLU   A OE2 1 
ATOM   911  N  N   . PHE   A 1 136 ? -34.780 -28.136 -21.175 1.00 58.57  ? 399  PHE   A N   1 
ATOM   912  C  CA  . PHE   A 1 136 ? -34.121 -28.278 -19.853 1.00 62.58  ? 399  PHE   A CA  1 
ATOM   913  C  C   . PHE   A 1 136 ? -34.988 -29.128 -18.922 1.00 68.05  ? 399  PHE   A C   1 
ATOM   914  O  O   . PHE   A 1 136 ? -34.448 -30.028 -18.264 1.00 62.04  ? 399  PHE   A O   1 
ATOM   915  C  CB  . PHE   A 1 136 ? -33.858 -26.890 -19.271 1.00 61.71  ? 399  PHE   A CB  1 
ATOM   916  C  CG  . PHE   A 1 136 ? -33.031 -26.853 -18.013 1.00 63.35  ? 399  PHE   A CG  1 
ATOM   917  C  CD1 . PHE   A 1 136 ? -31.656 -27.007 -18.064 1.00 59.41  ? 399  PHE   A CD1 1 
ATOM   918  C  CD2 . PHE   A 1 136 ? -33.623 -26.639 -16.780 1.00 61.33  ? 399  PHE   A CD2 1 
ATOM   919  C  CE1 . PHE   A 1 136 ? -30.894 -26.962 -16.909 1.00 57.82  ? 399  PHE   A CE1 1 
ATOM   920  C  CE2 . PHE   A 1 136 ? -32.859 -26.592 -15.626 1.00 64.12  ? 399  PHE   A CE2 1 
ATOM   921  C  CZ  . PHE   A 1 136 ? -31.496 -26.754 -15.693 1.00 61.18  ? 399  PHE   A CZ  1 
ATOM   922  N  N   . THR   A 1 137 ? -36.292 -28.851 -18.889 0.50 66.98  ? 400  THR   A N   1 
ATOM   923  C  CA  . THR   A 1 137 ? -37.208 -29.593 -17.986 0.50 66.99  ? 400  THR   A CA  1 
ATOM   924  C  C   . THR   A 1 137 ? -37.134 -31.085 -18.319 0.50 67.00  ? 400  THR   A C   1 
ATOM   925  O  O   . THR   A 1 137 ? -36.996 -31.883 -17.388 0.50 63.75  ? 400  THR   A O   1 
ATOM   926  C  CB  . THR   A 1 137 ? -38.635 -29.045 -18.092 0.50 65.85  ? 400  THR   A CB  1 
ATOM   927  O  OG1 . THR   A 1 137 ? -38.596 -27.657 -17.765 0.50 66.37  ? 400  THR   A OG1 1 
ATOM   928  C  CG2 . THR   A 1 137 ? -39.611 -29.764 -17.187 0.50 65.79  ? 400  THR   A CG2 1 
ATOM   929  N  N   . ARG   A 1 138 ? -37.186 -31.432 -19.603 0.50 69.72  ? 401  ARG   A N   1 
ATOM   930  C  CA  . ARG   A 1 138 ? -37.194 -32.862 -20.005 0.50 72.72  ? 401  ARG   A CA  1 
ATOM   931  C  C   . ARG   A 1 138 ? -35.900 -33.530 -19.536 0.50 72.55  ? 401  ARG   A C   1 
ATOM   932  O  O   . ARG   A 1 138 ? -35.969 -34.661 -19.028 0.50 74.95  ? 401  ARG   A O   1 
ATOM   933  C  CB  . ARG   A 1 138 ? -37.360 -32.966 -21.522 0.50 78.86  ? 401  ARG   A CB  1 
ATOM   934  C  CG  . ARG   A 1 138 ? -37.610 -34.378 -22.028 0.50 82.79  ? 401  ARG   A CG  1 
ATOM   935  C  CD  . ARG   A 1 138 ? -38.387 -34.357 -23.330 0.50 83.86  ? 401  ARG   A CD  1 
ATOM   936  N  NE  . ARG   A 1 138 ? -37.696 -33.612 -24.371 0.50 85.37  ? 401  ARG   A NE  1 
ATOM   937  C  CZ  . ARG   A 1 138 ? -36.925 -34.160 -25.301 0.50 84.11  ? 401  ARG   A CZ  1 
ATOM   938  N  NH1 . ARG   A 1 138 ? -36.752 -35.471 -25.326 0.50 83.52  ? 401  ARG   A NH1 1 
ATOM   939  N  NH2 . ARG   A 1 138 ? -36.335 -33.399 -26.205 0.50 83.20  ? 401  ARG   A NH2 1 
ATOM   940  N  N   . LYS   A 1 139 ? -34.769 -32.846 -19.694 0.50 71.52  ? 402  LYS   A N   1 
ATOM   941  C  CA  . LYS   A 1 139 ? -33.469 -33.413 -19.261 0.50 71.71  ? 402  LYS   A CA  1 
ATOM   942  C  C   . LYS   A 1 139 ? -33.563 -33.776 -17.779 0.50 76.39  ? 402  LYS   A C   1 
ATOM   943  O  O   . LYS   A 1 139 ? -33.124 -34.881 -17.412 0.50 77.85  ? 402  LYS   A O   1 
ATOM   944  C  CB  . LYS   A 1 139 ? -32.343 -32.404 -19.501 0.50 69.94  ? 402  LYS   A CB  1 
ATOM   945  C  CG  . LYS   A 1 139 ? -32.174 -31.952 -20.944 0.50 69.75  ? 402  LYS   A CG  1 
ATOM   946  C  CD  . LYS   A 1 139 ? -31.022 -30.992 -21.143 0.50 68.53  ? 402  LYS   A CD  1 
ATOM   947  C  CE  . LYS   A 1 139 ? -29.669 -31.633 -20.921 0.50 66.20  ? 402  LYS   A CE  1 
ATOM   948  N  NZ  . LYS   A 1 139 ? -29.400 -32.703 -21.910 0.50 63.36  ? 402  LYS   A NZ  1 
ATOM   949  N  N   . VAL   A 1 140 ? -34.123 -32.878 -16.966 0.50 80.45  ? 403  VAL   A N   1 
ATOM   950  C  CA  . VAL   A 1 140 ? -34.216 -33.123 -15.497 0.50 84.03  ? 403  VAL   A CA  1 
ATOM   951  C  C   . VAL   A 1 140 ? -35.186 -34.284 -15.249 0.50 88.07  ? 403  VAL   A C   1 
ATOM   952  O  O   . VAL   A 1 140 ? -34.870 -35.140 -14.401 0.50 92.07  ? 403  VAL   A O   1 
ATOM   953  C  CB  . VAL   A 1 140 ? -34.629 -31.851 -14.730 0.50 84.56  ? 403  VAL   A CB  1 
ATOM   954  C  CG1 . VAL   A 1 140 ? -33.991 -30.602 -15.313 0.50 84.67  ? 403  VAL   A CG1 1 
ATOM   955  C  CG2 . VAL   A 1 140 ? -36.136 -31.690 -14.629 0.50 85.44  ? 403  VAL   A CG2 1 
ATOM   956  N  N   . ARG   A 1 141 ? -36.308 -34.318 -15.972 0.36 86.54  ? 404  ARG   A N   1 
ATOM   957  C  CA  . ARG   A 1 141 ? -37.294 -35.417 -15.813 0.36 86.75  ? 404  ARG   A CA  1 
ATOM   958  C  C   . ARG   A 1 141 ? -36.609 -36.731 -16.179 0.36 87.01  ? 404  ARG   A C   1 
ATOM   959  O  O   . ARG   A 1 141 ? -36.949 -37.763 -15.575 0.36 86.37  ? 404  ARG   A O   1 
ATOM   960  C  CB  . ARG   A 1 141 ? -38.515 -35.183 -16.703 0.36 87.33  ? 404  ARG   A CB  1 
ATOM   961  C  CG  . ARG   A 1 141 ? -39.061 -33.764 -16.640 0.36 89.12  ? 404  ARG   A CG  1 
ATOM   962  C  CD  . ARG   A 1 141 ? -39.280 -33.280 -15.220 0.36 90.89  ? 404  ARG   A CD  1 
ATOM   963  N  NE  . ARG   A 1 141 ? -40.560 -33.711 -14.680 0.36 90.37  ? 404  ARG   A NE  1 
ATOM   964  C  CZ  . ARG   A 1 141 ? -41.690 -33.023 -14.797 0.36 90.54  ? 404  ARG   A CZ  1 
ATOM   965  N  NH1 . ARG   A 1 141 ? -41.696 -31.866 -15.436 0.36 90.77  ? 404  ARG   A NH1 1 
ATOM   966  N  NH2 . ARG   A 1 141 ? -42.808 -33.492 -14.273 0.36 90.02  ? 404  ARG   A NH2 1 
ATOM   967  N  N   . SER   A 1 142 ? -35.681 -36.680 -17.136 0.36 90.19  ? 405  SER   A N   1 
ATOM   968  C  CA  . SER   A 1 142 ? -34.952 -37.899 -17.569 0.36 95.10  ? 405  SER   A CA  1 
ATOM   969  C  C   . SER   A 1 142 ? -33.762 -38.137 -16.638 0.36 96.52  ? 405  SER   A C   1 
ATOM   970  O  O   . SER   A 1 142 ? -33.083 -39.166 -16.810 0.36 96.79  ? 405  SER   A O   1 
ATOM   971  C  CB  . SER   A 1 142 ? -34.517 -37.778 -19.002 0.36 96.95  ? 405  SER   A CB  1 
ATOM   972  O  OG  . SER   A 1 142 ? -33.733 -36.610 -19.193 0.36 99.47  ? 405  SER   A OG  1 
ATOM   973  N  N   . ASN   A 1 143 ? -33.519 -37.215 -15.703 0.36 98.06  ? 406  ASN   A N   1 
ATOM   974  C  CA  . ASN   A 1 143 ? -32.423 -37.379 -14.709 0.36 99.93  ? 406  ASN   A CA  1 
ATOM   975  C  C   . ASN   A 1 143 ? -31.068 -37.362 -15.422 0.36 100.50 ? 406  ASN   A C   1 
ATOM   976  O  O   . ASN   A 1 143 ? -30.692 -38.399 -15.997 0.36 101.59 ? 406  ASN   A O   1 
ATOM   977  C  CB  . ASN   A 1 143 ? -32.609 -38.642 -13.863 0.36 101.47 ? 406  ASN   A CB  1 
ATOM   978  C  CG  . ASN   A 1 143 ? -34.014 -38.782 -13.317 0.36 102.06 ? 406  ASN   A CG  1 
ATOM   979  O  OD1 . ASN   A 1 143 ? -34.867 -37.931 -13.558 0.36 100.65 ? 406  ASN   A OD1 1 
ATOM   980  N  ND2 . ASN   A 1 143 ? -34.266 -39.853 -12.583 0.36 102.26 ? 406  ASN   A ND2 1 
ATOM   981  N  N   . ALA   A 1 144 ? -30.365 -36.229 -15.371 0.50 102.54 ? 407  ALA   A N   1 
ATOM   982  C  CA  . ALA   A 1 144 ? -29.026 -36.112 -15.995 0.50 104.59 ? 407  ALA   A CA  1 
ATOM   983  C  C   . ALA   A 1 144 ? -28.140 -35.220 -15.119 0.50 107.22 ? 407  ALA   A C   1 
ATOM   984  O  O   . ALA   A 1 144 ? -28.688 -34.332 -14.439 0.50 105.63 ? 407  ALA   A O   1 
ATOM   985  C  CB  . ALA   A 1 144 ? -29.147 -35.565 -17.396 0.50 101.53 ? 407  ALA   A CB  1 
ATOM   986  N  N   . ALA   A 1 145 ? -26.824 -35.450 -15.142 0.36 105.83 ? 408  ALA   A N   1 
ATOM   987  C  CA  . ALA   A 1 145 ? -25.890 -34.679 -14.286 0.36 103.29 ? 408  ALA   A CA  1 
ATOM   988  C  C   . ALA   A 1 145 ? -25.865 -33.211 -14.727 0.36 102.59 ? 408  ALA   A C   1 
ATOM   989  O  O   . ALA   A 1 145 ? -25.170 -32.897 -15.714 0.36 102.74 ? 408  ALA   A O   1 
ATOM   990  C  CB  . ALA   A 1 145 ? -24.512 -35.293 -14.344 0.36 102.20 ? 408  ALA   A CB  1 
ATOM   991  N  N   . LEU   A 1 146 ? -26.595 -32.350 -14.010 0.36 100.24 ? 409  LEU   A N   1 
ATOM   992  C  CA  . LEU   A 1 146 ? -26.655 -30.884 -14.251 0.36 98.34  ? 409  LEU   A CA  1 
ATOM   993  C  C   . LEU   A 1 146 ? -25.931 -30.157 -13.111 0.36 96.11  ? 409  LEU   A C   1 
ATOM   994  O  O   . LEU   A 1 146 ? -26.027 -28.921 -13.043 0.36 92.34  ? 409  LEU   A O   1 
ATOM   995  C  CB  . LEU   A 1 146 ? -28.121 -30.449 -14.351 0.36 98.57  ? 409  LEU   A CB  1 
ATOM   996  C  CG  . LEU   A 1 146 ? -28.869 -30.942 -15.590 0.36 99.41  ? 409  LEU   A CG  1 
ATOM   997  C  CD1 . LEU   A 1 146 ? -30.302 -30.433 -15.601 0.36 99.39  ? 409  LEU   A CD1 1 
ATOM   998  C  CD2 . LEU   A 1 146 ? -28.150 -30.524 -16.864 0.36 99.54  ? 409  LEU   A CD2 1 
ATOM   999  N  N   . GLY   A 1 147 ? -25.244 -30.912 -12.247 0.36 95.11  ? 410  GLY   A N   1 
ATOM   1000 C  CA  . GLY   A 1 147 ? -24.396 -30.384 -11.159 0.36 93.21  ? 410  GLY   A CA  1 
ATOM   1001 C  C   . GLY   A 1 147 ? -25.023 -29.190 -10.457 0.36 91.56  ? 410  GLY   A C   1 
ATOM   1002 O  O   . GLY   A 1 147 ? -24.285 -28.226 -10.174 0.36 90.74  ? 410  GLY   A O   1 
ATOM   1003 N  N   . ALA   A 1 148 ? -26.330 -29.251 -10.174 0.36 88.82  ? 411  ALA   A N   1 
ATOM   1004 C  CA  . ALA   A 1 148 ? -27.102 -28.198 -9.472  0.36 86.25  ? 411  ALA   A CA  1 
ATOM   1005 C  C   . ALA   A 1 148 ? -27.041 -28.435 -7.958  0.36 86.58  ? 411  ALA   A C   1 
ATOM   1006 O  O   . ALA   A 1 148 ? -26.428 -29.438 -7.543  0.36 84.93  ? 411  ALA   A O   1 
ATOM   1007 C  CB  . ALA   A 1 148 ? -28.526 -28.186 -9.972  0.36 84.31  ? 411  ALA   A CB  1 
ATOM   1008 N  N   . ILE   A 1 149 ? -27.649 -27.538 -7.172  0.36 86.78  ? 412  ILE   A N   1 
ATOM   1009 C  CA  . ILE   A 1 149 ? -27.754 -27.638 -5.684  0.36 86.52  ? 412  ILE   A CA  1 
ATOM   1010 C  C   . ILE   A 1 149 ? -29.199 -27.999 -5.319  0.36 85.32  ? 412  ILE   A C   1 
ATOM   1011 O  O   . ILE   A 1 149 ? -29.469 -29.210 -5.190  0.36 80.87  ? 412  ILE   A O   1 
ATOM   1012 C  CB  . ILE   A 1 149 ? -27.306 -26.328 -5.002  0.36 87.11  ? 412  ILE   A CB  1 
ATOM   1013 C  CG1 . ILE   A 1 149 ? -28.406 -25.262 -5.037  0.36 89.31  ? 412  ILE   A CG1 1 
ATOM   1014 C  CG2 . ILE   A 1 149 ? -26.005 -25.821 -5.604  0.36 85.30  ? 412  ILE   A CG2 1 
ATOM   1015 C  CD1 . ILE   A 1 149 ? -28.139 -24.069 -4.144  0.36 88.49  ? 412  ILE   A CD1 1 
ATOM   1016 N  N   . LYS   A 1 155 ? -35.778 -24.305 -0.631  0.36 94.04  ? 418  LYS   A N   1 
ATOM   1017 C  CA  . LYS   A 1 155 ? -37.074 -23.879 -1.226  0.36 93.08  ? 418  LYS   A CA  1 
ATOM   1018 C  C   . LYS   A 1 155 ? -37.681 -25.056 -2.003  0.36 92.71  ? 418  LYS   A C   1 
ATOM   1019 O  O   . LYS   A 1 155 ? -38.920 -25.207 -1.970  0.36 93.27  ? 418  LYS   A O   1 
ATOM   1020 C  CB  . LYS   A 1 155 ? -36.862 -22.655 -2.123  0.36 92.53  ? 418  LYS   A CB  1 
ATOM   1021 C  CG  . LYS   A 1 155 ? -38.017 -21.663 -2.152  0.36 91.31  ? 418  LYS   A CG  1 
ATOM   1022 C  CD  . LYS   A 1 155 ? -39.354 -22.300 -2.463  0.36 90.21  ? 418  LYS   A CD  1 
ATOM   1023 C  CE  . LYS   A 1 155 ? -40.497 -21.308 -2.463  0.36 88.30  ? 418  LYS   A CE  1 
ATOM   1024 N  NZ  . LYS   A 1 155 ? -41.795 -21.978 -2.706  0.36 87.22  ? 418  LYS   A NZ  1 
ATOM   1025 N  N   . TRP   A 1 156 ? -36.836 -25.849 -2.674  0.36 91.40  ? 419  TRP   A N   1 
ATOM   1026 C  CA  . TRP   A 1 156 ? -37.212 -27.080 -3.424  0.36 91.48  ? 419  TRP   A CA  1 
ATOM   1027 C  C   . TRP   A 1 156 ? -36.241 -28.212 -3.069  0.36 92.00  ? 419  TRP   A C   1 
ATOM   1028 O  O   . TRP   A 1 156 ? -35.029 -27.939 -2.980  0.36 90.35  ? 419  TRP   A O   1 
ATOM   1029 C  CB  . TRP   A 1 156 ? -37.215 -26.827 -4.937  0.36 91.48  ? 419  TRP   A CB  1 
ATOM   1030 C  CG  . TRP   A 1 156 ? -38.071 -25.678 -5.370  0.36 89.16  ? 419  TRP   A CG  1 
ATOM   1031 C  CD1 . TRP   A 1 156 ? -39.418 -25.692 -5.590  0.36 88.27  ? 419  TRP   A CD1 1 
ATOM   1032 C  CD2 . TRP   A 1 156 ? -37.632 -24.337 -5.651  0.36 87.46  ? 419  TRP   A CD2 1 
ATOM   1033 N  NE1 . TRP   A 1 156 ? -39.848 -24.453 -5.981  0.36 89.37  ? 419  TRP   A NE1 1 
ATOM   1034 C  CE2 . TRP   A 1 156 ? -38.775 -23.601 -6.028  0.36 87.73  ? 419  TRP   A CE2 1 
ATOM   1035 C  CE3 . TRP   A 1 156 ? -36.392 -23.689 -5.619  0.36 87.15  ? 419  TRP   A CE3 1 
ATOM   1036 C  CZ2 . TRP   A 1 156 ? -38.710 -22.251 -6.368  0.36 88.98  ? 419  TRP   A CZ2 1 
ATOM   1037 C  CZ3 . TRP   A 1 156 ? -36.329 -22.355 -5.956  0.36 87.20  ? 419  TRP   A CZ3 1 
ATOM   1038 C  CH2 . TRP   A 1 156 ? -37.474 -21.649 -6.324  0.36 89.00  ? 419  TRP   A CH2 1 
ATOM   1039 N  N   . LYS   A 1 157 ? -36.755 -29.434 -2.899  0.36 94.04  ? 420  LYS   A N   1 
ATOM   1040 C  CA  . LYS   A 1 157 ? -35.948 -30.634 -2.551  0.36 95.68  ? 420  LYS   A CA  1 
ATOM   1041 C  C   . LYS   A 1 157 ? -34.998 -30.955 -3.712  0.36 96.47  ? 420  LYS   A C   1 
ATOM   1042 O  O   . LYS   A 1 157 ? -33.789 -30.677 -3.578  0.36 95.07  ? 420  LYS   A O   1 
ATOM   1043 C  CB  . LYS   A 1 157 ? -36.860 -31.823 -2.230  0.36 97.07  ? 420  LYS   A CB  1 
ATOM   1044 C  CG  . LYS   A 1 157 ? -36.146 -33.162 -2.084  0.36 97.05  ? 420  LYS   A CG  1 
ATOM   1045 C  CD  . LYS   A 1 157 ? -37.061 -34.356 -2.249  0.36 96.83  ? 420  LYS   A CD  1 
ATOM   1046 C  CE  . LYS   A 1 157 ? -38.259 -34.317 -1.324  0.36 95.73  ? 420  LYS   A CE  1 
ATOM   1047 N  NZ  . LYS   A 1 157 ? -39.200 -35.427 -1.602  0.36 96.44  ? 420  LYS   A NZ  1 
ATOM   1048 N  N   . SER   A 1 158 ? -35.536 -31.504 -4.807  1.00 97.76  ? 421  SER   A N   1 
ATOM   1049 C  CA  . SER   A 1 158 ? -34.755 -31.970 -5.981  1.00 97.32  ? 421  SER   A CA  1 
ATOM   1050 C  C   . SER   A 1 158 ? -34.808 -30.919 -7.090  1.00 103.73 ? 421  SER   A C   1 
ATOM   1051 O  O   . SER   A 1 158 ? -35.496 -29.879 -6.924  1.00 93.04  ? 421  SER   A O   1 
ATOM   1052 C  CB  . SER   A 1 158 ? -35.253 -33.319 -6.469  1.00 88.87  ? 421  SER   A CB  1 
ATOM   1053 O  OG  . SER   A 1 158 ? -36.662 -33.324 -6.638  1.00 88.60  ? 421  SER   A OG  1 
ATOM   1054 N  N   . ALA   A 1 159 ? -34.228 -31.236 -8.247  1.00 107.10 ? 422  ALA   A N   1 
ATOM   1055 C  CA  . ALA   A 1 159 ? -34.294 -30.308 -9.399  1.00 99.08  ? 422  ALA   A CA  1 
ATOM   1056 C  C   . ALA   A 1 159 ? -35.645 -30.451 -10.102 1.00 88.08  ? 422  ALA   A C   1 
ATOM   1057 O  O   . ALA   A 1 159 ? -36.152 -29.445 -10.607 1.00 78.22  ? 422  ALA   A O   1 
ATOM   1058 C  CB  . ALA   A 1 159 ? -33.156 -30.606 -10.332 1.00 106.47 ? 422  ALA   A CB  1 
ATOM   1059 N  N   . ARG   A 1 160 ? -36.207 -31.659 -10.099 0.50 87.11  ? 423  ARG   A N   1 
ATOM   1060 C  CA  . ARG   A 1 160 ? -37.503 -31.907 -10.778 0.50 88.25  ? 423  ARG   A CA  1 
ATOM   1061 C  C   . ARG   A 1 160 ? -38.581 -30.991 -10.185 0.50 88.89  ? 423  ARG   A C   1 
ATOM   1062 O  O   . ARG   A 1 160 ? -39.366 -30.418 -10.962 0.50 90.12  ? 423  ARG   A O   1 
ATOM   1063 C  CB  . ARG   A 1 160 ? -37.873 -33.383 -10.627 0.50 91.15  ? 423  ARG   A CB  1 
ATOM   1064 C  CG  . ARG   A 1 160 ? -39.101 -33.802 -11.422 0.50 97.87  ? 423  ARG   A CG  1 
ATOM   1065 C  CD  . ARG   A 1 160 ? -39.510 -35.225 -11.096 0.50 101.37 ? 423  ARG   A CD  1 
ATOM   1066 N  NE  . ARG   A 1 160 ? -38.427 -36.175 -11.305 0.50 102.76 ? 423  ARG   A NE  1 
ATOM   1067 C  CZ  . ARG   A 1 160 ? -38.254 -36.888 -12.411 0.50 104.23 ? 423  ARG   A CZ  1 
ATOM   1068 N  NH1 . ARG   A 1 160 ? -37.237 -37.727 -12.505 0.50 101.43 ? 423  ARG   A NH1 1 
ATOM   1069 N  NH2 . ARG   A 1 160 ? -39.103 -36.765 -13.415 0.50 103.87 ? 423  ARG   A NH2 1 
ATOM   1070 N  N   . GLU   A 1 161 ? -38.614 -30.850 -8.859  0.36 86.97  ? 424  GLU   A N   1 
ATOM   1071 C  CA  . GLU   A 1 161 ? -39.673 -30.034 -8.209  0.36 84.74  ? 424  GLU   A CA  1 
ATOM   1072 C  C   . GLU   A 1 161 ? -39.561 -28.580 -8.667  0.36 83.84  ? 424  GLU   A C   1 
ATOM   1073 O  O   . GLU   A 1 161 ? -40.610 -27.968 -8.938  0.36 83.42  ? 424  GLU   A O   1 
ATOM   1074 C  CB  . GLU   A 1 161 ? -39.533 -30.102 -6.689  0.36 84.29  ? 424  GLU   A CB  1 
ATOM   1075 C  CG  . GLU   A 1 161 ? -39.524 -31.515 -6.141  0.36 84.10  ? 424  GLU   A CG  1 
ATOM   1076 C  CD  . GLU   A 1 161 ? -39.330 -31.591 -4.637  0.36 82.41  ? 424  GLU   A CD  1 
ATOM   1077 O  OE1 . GLU   A 1 161 ? -39.074 -30.537 -4.022  0.36 78.06  ? 424  GLU   A OE1 1 
ATOM   1078 O  OE2 . GLU   A 1 161 ? -39.439 -32.703 -4.084  0.36 82.41  ? 424  GLU   A OE2 1 
ATOM   1079 N  N   . ALA   A 1 162 ? -38.339 -28.052 -8.752  1.00 83.22  ? 425  ALA   A N   1 
ATOM   1080 C  CA  . ALA   A 1 162 ? -38.148 -26.624 -9.094  1.00 79.68  ? 425  ALA   A CA  1 
ATOM   1081 C  C   . ALA   A 1 162 ? -38.646 -26.341 -10.509 1.00 76.97  ? 425  ALA   A C   1 
ATOM   1082 O  O   . ALA   A 1 162 ? -39.188 -25.249 -10.731 1.00 71.72  ? 425  ALA   A O   1 
ATOM   1083 C  CB  . ALA   A 1 162 ? -36.696 -26.258 -8.948  1.00 80.11  ? 425  ALA   A CB  1 
ATOM   1084 N  N   . VAL   A 1 163 ? -38.457 -27.290 -11.422 1.00 80.11  ? 426  VAL   A N   1 
ATOM   1085 C  CA  . VAL   A 1 163 ? -38.858 -27.078 -12.844 1.00 88.01  ? 426  VAL   A CA  1 
ATOM   1086 C  C   . VAL   A 1 163 ? -40.382 -27.049 -12.902 1.00 88.04  ? 426  VAL   A C   1 
ATOM   1087 O  O   . VAL   A 1 163 ? -40.925 -26.628 -13.935 1.00 92.19  ? 426  VAL   A O   1 
ATOM   1088 C  CB  . VAL   A 1 163 ? -38.280 -28.164 -13.771 1.00 89.34  ? 426  VAL   A CB  1 
ATOM   1089 C  CG1 . VAL   A 1 163 ? -36.785 -28.350 -13.565 1.00 82.08  ? 426  VAL   A CG1 1 
ATOM   1090 C  CG2 . VAL   A 1 163 ? -39.011 -29.488 -13.646 1.00 95.02  ? 426  VAL   A CG2 1 
ATOM   1091 N  N   . GLU   A 1 164 ? -41.034 -27.474 -11.819 0.36 88.06  ? 427  GLU   A N   1 
ATOM   1092 C  CA  . GLU   A 1 164 ? -42.519 -27.494 -11.772 0.36 86.37  ? 427  GLU   A CA  1 
ATOM   1093 C  C   . GLU   A 1 164 ? -43.018 -26.312 -10.933 0.36 84.69  ? 427  GLU   A C   1 
ATOM   1094 O  O   . GLU   A 1 164 ? -44.222 -26.287 -10.618 0.36 86.56  ? 427  GLU   A O   1 
ATOM   1095 C  CB  . GLU   A 1 164 ? -42.979 -28.835 -11.203 0.36 86.47  ? 427  GLU   A CB  1 
ATOM   1096 C  CG  . GLU   A 1 164 ? -42.414 -30.024 -11.959 0.36 86.83  ? 427  GLU   A CG  1 
ATOM   1097 C  CD  . GLU   A 1 164 ? -42.337 -31.306 -11.149 0.36 88.51  ? 427  GLU   A CD  1 
ATOM   1098 O  OE1 . GLU   A 1 164 ? -42.654 -31.262 -9.944  0.36 87.30  ? 427  GLU   A OE1 1 
ATOM   1099 O  OE2 . GLU   A 1 164 ? -41.957 -32.345 -11.725 0.36 89.04  ? 427  GLU   A OE2 1 
ATOM   1100 N  N   . ASP   A 1 165 ? -42.130 -25.374 -10.590 0.36 82.47  ? 428  ASP   A N   1 
ATOM   1101 C  CA  . ASP   A 1 165 ? -42.522 -24.180 -9.792  0.36 80.66  ? 428  ASP   A CA  1 
ATOM   1102 C  C   . ASP   A 1 165 ? -42.278 -22.920 -10.623 0.36 80.80  ? 428  ASP   A C   1 
ATOM   1103 O  O   . ASP   A 1 165 ? -41.121 -22.688 -11.019 0.36 81.09  ? 428  ASP   A O   1 
ATOM   1104 C  CB  . ASP   A 1 165 ? -41.789 -24.119 -8.450  0.36 79.88  ? 428  ASP   A CB  1 
ATOM   1105 C  CG  . ASP   A 1 165 ? -42.266 -22.989 -7.552  0.36 79.00  ? 428  ASP   A CG  1 
ATOM   1106 O  OD1 . ASP   A 1 165 ? -42.766 -21.983 -8.088  0.36 75.66  ? 428  ASP   A OD1 1 
ATOM   1107 O  OD2 . ASP   A 1 165 ? -42.145 -23.129 -6.320  0.36 78.20  ? 428  ASP   A OD2 1 
ATOM   1108 N  N   . SER   A 1 166 ? -43.329 -22.132 -10.847 0.50 80.74  ? 429  SER   A N   1 
ATOM   1109 C  CA  . SER   A 1 166 ? -43.212 -20.917 -11.691 0.50 80.11  ? 429  SER   A CA  1 
ATOM   1110 C  C   . SER   A 1 166 ? -42.360 -19.859 -10.987 0.50 78.18  ? 429  SER   A C   1 
ATOM   1111 O  O   . SER   A 1 166 ? -41.764 -19.026 -11.690 0.50 80.88  ? 429  SER   A O   1 
ATOM   1112 C  CB  . SER   A 1 166 ? -44.575 -20.389 -12.029 0.50 82.55  ? 429  SER   A CB  1 
ATOM   1113 O  OG  . SER   A 1 166 ? -45.398 -21.426 -12.542 0.50 83.49  ? 429  SER   A OG  1 
ATOM   1114 N  N   . GLY   A 1 167 ? -42.318 -19.890 -9.655  0.50 77.19  ? 430  GLY   A N   1 
ATOM   1115 C  CA  . GLY   A 1 167 ? -41.504 -18.921 -8.898  0.50 74.32  ? 430  GLY   A CA  1 
ATOM   1116 C  C   . GLY   A 1 167 ? -40.047 -19.033 -9.290  0.50 73.84  ? 430  GLY   A C   1 
ATOM   1117 O  O   . GLY   A 1 167 ? -39.418 -17.990 -9.514  0.50 73.02  ? 430  GLY   A O   1 
ATOM   1118 N  N   . PHE   A 1 168 ? -39.539 -20.262 -9.387  0.50 74.27  ? 431  PHE   A N   1 
ATOM   1119 C  CA  . PHE   A 1 168 ? -38.138 -20.489 -9.815  0.50 77.35  ? 431  PHE   A CA  1 
ATOM   1120 C  C   . PHE   A 1 168 ? -37.911 -19.794 -11.152 0.50 73.77  ? 431  PHE   A C   1 
ATOM   1121 O  O   . PHE   A 1 168 ? -36.876 -19.134 -11.328 0.50 73.54  ? 431  PHE   A O   1 
ATOM   1122 C  CB  . PHE   A 1 168 ? -37.884 -21.991 -9.951  0.50 81.37  ? 431  PHE   A CB  1 
ATOM   1123 C  CG  . PHE   A 1 168 ? -36.687 -22.378 -10.781 0.50 82.19  ? 431  PHE   A CG  1 
ATOM   1124 C  CD1 . PHE   A 1 168 ? -35.440 -22.535 -10.199 0.50 82.83  ? 431  PHE   A CD1 1 
ATOM   1125 C  CD2 . PHE   A 1 168 ? -36.811 -22.605 -12.142 0.50 83.96  ? 431  PHE   A CD2 1 
ATOM   1126 C  CE1 . PHE   A 1 168 ? -34.342 -22.897 -10.962 0.50 83.85  ? 431  PHE   A CE1 1 
ATOM   1127 C  CE2 . PHE   A 1 168 ? -35.712 -22.966 -12.904 0.50 84.83  ? 431  PHE   A CE2 1 
ATOM   1128 C  CZ  . PHE   A 1 168 ? -34.480 -23.112 -12.313 0.50 85.48  ? 431  PHE   A CZ  1 
ATOM   1129 N  N   . TRP   A 1 169 ? -38.863 -19.948 -12.067 1.00 73.81  ? 432  TRP   A N   1 
ATOM   1130 C  CA  . TRP   A 1 169 ? -38.723 -19.353 -13.420 1.00 71.58  ? 432  TRP   A CA  1 
ATOM   1131 C  C   . TRP   A 1 169 ? -38.762 -17.823 -13.321 1.00 73.12  ? 432  TRP   A C   1 
ATOM   1132 O  O   . TRP   A 1 169 ? -38.052 -17.164 -14.092 1.00 72.78  ? 432  TRP   A O   1 
ATOM   1133 C  CB  . TRP   A 1 169 ? -39.773 -19.949 -14.365 1.00 62.26  ? 432  TRP   A CB  1 
ATOM   1134 C  CG  . TRP   A 1 169 ? -39.553 -21.405 -14.632 1.00 61.38  ? 432  TRP   A CG  1 
ATOM   1135 C  CD1 . TRP   A 1 169 ? -40.364 -22.440 -14.272 1.00 66.21  ? 432  TRP   A CD1 1 
ATOM   1136 C  CD2 . TRP   A 1 169 ? -38.426 -21.997 -15.303 1.00 67.15  ? 432  TRP   A CD2 1 
ATOM   1137 N  NE1 . TRP   A 1 169 ? -39.827 -23.630 -14.681 1.00 68.02  ? 432  TRP   A NE1 1 
ATOM   1138 C  CE2 . TRP   A 1 169 ? -38.639 -23.390 -15.316 1.00 62.36  ? 432  TRP   A CE2 1 
ATOM   1139 C  CE3 . TRP   A 1 169 ? -37.267 -21.488 -15.897 1.00 66.98  ? 432  TRP   A CE3 1 
ATOM   1140 C  CZ2 . TRP   A 1 169 ? -37.734 -24.276 -15.899 1.00 67.99  ? 432  TRP   A CZ2 1 
ATOM   1141 C  CZ3 . TRP   A 1 169 ? -36.375 -22.364 -16.474 1.00 72.26  ? 432  TRP   A CZ3 1 
ATOM   1142 C  CH2 . TRP   A 1 169 ? -36.606 -23.738 -16.472 1.00 66.86  ? 432  TRP   A CH2 1 
ATOM   1143 N  N   . GLU   A 1 170 ? -39.533 -17.280 -12.381 0.50 76.35  ? 433  GLU   A N   1 
ATOM   1144 C  CA  . GLU   A 1 170 ? -39.534 -15.810 -12.174 0.50 78.18  ? 433  GLU   A CA  1 
ATOM   1145 C  C   . GLU   A 1 170 ? -38.130 -15.413 -11.718 0.50 75.66  ? 433  GLU   A C   1 
ATOM   1146 O  O   . GLU   A 1 170 ? -37.653 -14.340 -12.122 0.50 74.67  ? 433  GLU   A O   1 
ATOM   1147 C  CB  . GLU   A 1 170 ? -40.607 -15.437 -11.151 0.50 79.97  ? 433  GLU   A CB  1 
ATOM   1148 C  CG  . GLU   A 1 170 ? -41.966 -16.024 -11.485 0.50 81.50  ? 433  GLU   A CG  1 
ATOM   1149 C  CD  . GLU   A 1 170 ? -42.981 -16.010 -10.355 0.50 83.06  ? 433  GLU   A CD  1 
ATOM   1150 O  OE1 . GLU   A 1 170 ? -42.841 -15.171 -9.444  0.50 83.75  ? 433  GLU   A OE1 1 
ATOM   1151 O  OE2 . GLU   A 1 170 ? -43.905 -16.848 -10.386 0.50 79.81  ? 433  GLU   A OE2 1 
ATOM   1152 N  N   . LEU   A 1 171 ? -37.502 -16.263 -10.909 1.00 74.30  ? 434  LEU   A N   1 
ATOM   1153 C  CA  . LEU   A 1 171 ? -36.121 -16.007 -10.433 1.00 80.05  ? 434  LEU   A CA  1 
ATOM   1154 C  C   . LEU   A 1 171 ? -35.171 -16.005 -11.635 1.00 77.13  ? 434  LEU   A C   1 
ATOM   1155 O  O   . LEU   A 1 171 ? -34.363 -15.071 -11.739 1.00 67.84  ? 434  LEU   A O   1 
ATOM   1156 C  CB  . LEU   A 1 171 ? -35.756 -17.118 -9.447  1.00 77.78  ? 434  LEU   A CB  1 
ATOM   1157 C  CG  . LEU   A 1 171 ? -36.610 -17.201 -8.184  1.00 77.26  ? 434  LEU   A CG  1 
ATOM   1158 C  CD1 . LEU   A 1 171 ? -36.210 -18.402 -7.344  1.00 80.18  ? 434  LEU   A CD1 1 
ATOM   1159 C  CD2 . LEU   A 1 171 ? -36.495 -15.924 -7.368  1.00 75.06  ? 434  LEU   A CD2 1 
ATOM   1160 N  N   . VAL   A 1 172 ? -35.291 -17.004 -12.512 1.00 70.78  ? 435  VAL   A N   1 
ATOM   1161 C  CA  . VAL   A 1 172 ? -34.459 -17.065 -13.746 1.00 62.09  ? 435  VAL   A CA  1 
ATOM   1162 C  C   . VAL   A 1 172 ? -34.685 -15.784 -14.539 1.00 63.75  ? 435  VAL   A C   1 
ATOM   1163 O  O   . VAL   A 1 172 ? -33.705 -15.221 -15.035 1.00 56.06  ? 435  VAL   A O   1 
ATOM   1164 C  CB  . VAL   A 1 172 ? -34.834 -18.301 -14.578 1.00 66.93  ? 435  VAL   A CB  1 
ATOM   1165 C  CG1 . VAL   A 1 172 ? -34.025 -18.386 -15.860 1.00 70.65  ? 435  VAL   A CG1 1 
ATOM   1166 C  CG2 . VAL   A 1 172 ? -34.705 -19.583 -13.772 1.00 70.21  ? 435  VAL   A CG2 1 
ATOM   1167 N  N   . ASP   A 1 173 ? -35.939 -15.337 -14.626 0.50 65.29  ? 436  ASP   A N   1 
ATOM   1168 C  CA  . ASP   A 1 173 ? -36.272 -14.129 -15.426 0.50 65.04  ? 436  ASP   A CA  1 
ATOM   1169 C  C   . ASP   A 1 173 ? -35.546 -12.910 -14.854 0.50 62.95  ? 436  ASP   A C   1 
ATOM   1170 O  O   . ASP   A 1 173 ? -34.927 -12.170 -15.636 0.50 64.39  ? 436  ASP   A O   1 
ATOM   1171 C  CB  . ASP   A 1 173 ? -37.785 -13.919 -15.483 0.50 69.33  ? 436  ASP   A CB  1 
ATOM   1172 C  CG  . ASP   A 1 173 ? -38.504 -14.954 -16.329 0.50 73.14  ? 436  ASP   A CG  1 
ATOM   1173 O  OD1 . ASP   A 1 173 ? -37.967 -15.312 -17.393 0.50 71.74  ? 436  ASP   A OD1 1 
ATOM   1174 O  OD2 . ASP   A 1 173 ? -39.593 -15.396 -15.914 0.50 75.72  ? 436  ASP   A OD2 1 
ATOM   1175 N  N   . LYS   A 1 174 ? -35.626 -12.714 -13.540 0.50 61.10  ? 437  LYS   A N   1 
ATOM   1176 C  CA  . LYS   A 1 174 ? -34.933 -11.571 -12.897 0.50 59.39  ? 437  LYS   A CA  1 
ATOM   1177 C  C   . LYS   A 1 174 ? -33.448 -11.671 -13.233 0.50 58.51  ? 437  LYS   A C   1 
ATOM   1178 O  O   . LYS   A 1 174 ? -32.860 -10.644 -13.614 0.50 55.76  ? 437  LYS   A O   1 
ATOM   1179 C  CB  . LYS   A 1 174 ? -35.147 -11.616 -11.383 0.50 60.59  ? 437  LYS   A CB  1 
ATOM   1180 C  CG  . LYS   A 1 174 ? -34.377 -10.583 -10.574 0.50 63.76  ? 437  LYS   A CG  1 
ATOM   1181 C  CD  . LYS   A 1 174 ? -34.654 -10.685 -9.089  0.50 66.96  ? 437  LYS   A CD  1 
ATOM   1182 C  CE  . LYS   A 1 174 ? -33.853 -9.707  -8.258  0.50 68.48  ? 437  LYS   A CE  1 
ATOM   1183 N  NZ  . LYS   A 1 174 ? -34.171 -9.830  -6.816  0.50 71.36  ? 437  LYS   A NZ  1 
ATOM   1184 N  N   . GLU   A 1 175 ? -32.883 -12.872 -13.117 0.50 54.75  ? 438  GLU   A N   1 
ATOM   1185 C  CA  . GLU   A 1 175 ? -31.434 -13.093 -13.376 0.50 53.12  ? 438  GLU   A CA  1 
ATOM   1186 C  C   . GLU   A 1 175 ? -31.111 -12.771 -14.838 0.50 49.91  ? 438  GLU   A C   1 
ATOM   1187 O  O   . GLU   A 1 175 ? -30.129 -12.037 -15.082 0.50 49.41  ? 438  GLU   A O   1 
ATOM   1188 C  CB  . GLU   A 1 175 ? -31.049 -14.528 -13.031 0.50 53.37  ? 438  GLU   A CB  1 
ATOM   1189 C  CG  . GLU   A 1 175 ? -30.315 -14.630 -11.713 0.50 55.45  ? 438  GLU   A CG  1 
ATOM   1190 C  CD  . GLU   A 1 175 ? -29.143 -13.674 -11.583 0.50 54.24  ? 438  GLU   A CD  1 
ATOM   1191 O  OE1 . GLU   A 1 175 ? -28.566 -13.613 -10.495 0.50 56.74  ? 438  GLU   A OE1 1 
ATOM   1192 O  OE2 . GLU   A 1 175 ? -28.810 -12.995 -12.572 0.50 55.88  ? 438  GLU   A OE2 1 
ATOM   1193 N  N   . ARG   A 1 176 ? -31.911 -13.308 -15.762 0.50 48.48  ? 439  ARG   A N   1 
ATOM   1194 C  CA  . ARG   A 1 176 ? -31.787 -13.091 -17.226 0.50 48.26  ? 439  ARG   A CA  1 
ATOM   1195 C  C   . ARG   A 1 176 ? -31.682 -11.587 -17.517 0.50 48.71  ? 439  ARG   A C   1 
ATOM   1196 O  O   . ARG   A 1 176 ? -30.592 -11.141 -17.952 0.50 46.22  ? 439  ARG   A O   1 
ATOM   1197 C  CB  . ARG   A 1 176 ? -32.985 -13.735 -17.924 0.50 50.40  ? 439  ARG   A CB  1 
ATOM   1198 C  CG  . ARG   A 1 176 ? -32.807 -13.956 -19.418 0.50 52.03  ? 439  ARG   A CG  1 
ATOM   1199 C  CD  . ARG   A 1 176 ? -33.644 -15.142 -19.859 0.50 54.87  ? 439  ARG   A CD  1 
ATOM   1200 N  NE  . ARG   A 1 176 ? -33.908 -15.126 -21.286 0.50 59.96  ? 439  ARG   A NE  1 
ATOM   1201 C  CZ  . ARG   A 1 176 ? -34.536 -16.094 -21.938 0.50 64.57  ? 439  ARG   A CZ  1 
ATOM   1202 N  NH1 . ARG   A 1 176 ? -34.957 -17.161 -21.276 0.50 66.37  ? 439  ARG   A NH1 1 
ATOM   1203 N  NH2 . ARG   A 1 176 ? -34.738 -15.990 -23.241 0.50 62.09  ? 439  ARG   A NH2 1 
ATOM   1204 N  N   . ASN   A 1 177 ? -32.761 -10.829 -17.278 0.50 49.44  ? 440  ASN   A N   1 
ATOM   1205 C  CA  . ASN   A 1 177 ? -32.825 -9.366  -17.560 0.50 48.43  ? 440  ASN   A CA  1 
ATOM   1206 C  C   . ASN   A 1 177 ? -31.606 -8.692  -16.920 0.50 47.55  ? 440  ASN   A C   1 
ATOM   1207 O  O   . ASN   A 1 177 ? -31.034 -7.778  -17.547 0.50 47.73  ? 440  ASN   A O   1 
ATOM   1208 C  CB  . ASN   A 1 177 ? -34.146 -8.738  -17.103 0.50 49.62  ? 440  ASN   A CB  1 
ATOM   1209 C  CG  . ASN   A 1 177 ? -35.240 -8.838  -18.148 0.50 48.60  ? 440  ASN   A CG  1 
ATOM   1210 O  OD1 . ASN   A 1 177 ? -35.067 -8.415  -19.292 0.50 46.24  ? 440  ASN   A OD1 1 
ATOM   1211 N  ND2 . ASN   A 1 177 ? -36.371 -9.407  -17.764 0.50 49.60  ? 440  ASN   A ND2 1 
ATOM   1212 N  N   . LEU   A 1 178 ? -31.207 -9.147  -15.730 0.50 49.03  ? 441  LEU   A N   1 
ATOM   1213 C  CA  . LEU   A 1 178 ? -29.940 -8.726  -15.073 0.50 51.02  ? 441  LEU   A CA  1 
ATOM   1214 C  C   . LEU   A 1 178 ? -28.770 -8.945  -16.041 0.50 51.44  ? 441  LEU   A C   1 
ATOM   1215 O  O   . LEU   A 1 178 ? -28.000 -7.985  -16.258 0.50 49.50  ? 441  LEU   A O   1 
ATOM   1216 C  CB  . LEU   A 1 178 ? -29.755 -9.512  -13.772 0.50 53.57  ? 441  LEU   A CB  1 
ATOM   1217 C  CG  . LEU   A 1 178 ? -30.456 -8.914  -12.552 0.50 55.15  ? 441  LEU   A CG  1 
ATOM   1218 C  CD1 . LEU   A 1 178 ? -30.286 -9.798  -11.324 0.50 55.97  ? 441  LEU   A CD1 1 
ATOM   1219 C  CD2 . LEU   A 1 178 ? -29.937 -7.509  -12.275 0.50 56.78  ? 441  LEU   A CD2 1 
ATOM   1220 N  N   . HIS   A 1 179 ? -28.650 -10.148 -16.617 0.50 51.36  ? 442  HIS   A N   1 
ATOM   1221 C  CA  . HIS   A 1 179 ? -27.597 -10.492 -17.615 0.50 52.02  ? 442  HIS   A CA  1 
ATOM   1222 C  C   . HIS   A 1 179 ? -27.719 -9.569  -18.837 0.50 51.87  ? 442  HIS   A C   1 
ATOM   1223 O  O   . HIS   A 1 179 ? -26.672 -9.123  -19.342 0.50 52.70  ? 442  HIS   A O   1 
ATOM   1224 C  CB  . HIS   A 1 179 ? -27.652 -11.977 -18.007 0.50 50.31  ? 442  HIS   A CB  1 
ATOM   1225 C  CG  . HIS   A 1 179 ? -27.094 -12.902 -16.976 0.50 49.43  ? 442  HIS   A CG  1 
ATOM   1226 N  ND1 . HIS   A 1 179 ? -27.096 -14.277 -17.136 0.50 47.06  ? 442  HIS   A ND1 1 
ATOM   1227 C  CD2 . HIS   A 1 179 ? -26.528 -12.660 -15.772 0.50 46.96  ? 442  HIS   A CD2 1 
ATOM   1228 C  CE1 . HIS   A 1 179 ? -26.554 -14.837 -16.077 0.50 47.40  ? 442  HIS   A CE1 1 
ATOM   1229 N  NE2 . HIS   A 1 179 ? -26.196 -13.866 -15.226 0.50 46.91  ? 442  HIS   A NE2 1 
ATOM   1230 N  N   . LEU   A 1 180 ? -28.945 -9.303  -19.304 0.50 54.37  ? 443  LEU   A N   1 
ATOM   1231 C  CA  . LEU   A 1 180 ? -29.217 -8.316  -20.385 0.50 52.21  ? 443  LEU   A CA  1 
ATOM   1232 C  C   . LEU   A 1 180 ? -28.850 -6.925  -19.857 0.50 51.23  ? 443  LEU   A C   1 
ATOM   1233 O  O   . LEU   A 1 180 ? -28.226 -6.155  -20.604 0.50 47.14  ? 443  LEU   A O   1 
ATOM   1234 C  CB  . LEU   A 1 180 ? -30.687 -8.410  -20.813 0.50 52.62  ? 443  LEU   A CB  1 
ATOM   1235 C  CG  . LEU   A 1 180 ? -31.135 -9.775  -21.345 0.50 53.59  ? 443  LEU   A CG  1 
ATOM   1236 C  CD1 . LEU   A 1 180 ? -32.652 -9.873  -21.413 0.50 54.11  ? 443  LEU   A CD1 1 
ATOM   1237 C  CD2 . LEU   A 1 180 ? -30.535 -10.058 -22.713 0.50 54.37  ? 443  LEU   A CD2 1 
ATOM   1238 N  N   . GLU   A 1 181 ? -29.179 -6.646  -18.592 0.50 55.16  ? 444  GLU   A N   1 
ATOM   1239 C  CA  . GLU   A 1 181 ? -28.789 -5.405  -17.865 0.50 58.07  ? 444  GLU   A CA  1 
ATOM   1240 C  C   . GLU   A 1 181 ? -27.269 -5.425  -17.638 0.50 59.18  ? 444  GLU   A C   1 
ATOM   1241 O  O   . GLU   A 1 181 ? -26.736 -4.443  -17.073 0.50 57.63  ? 444  GLU   A O   1 
ATOM   1242 C  CB  . GLU   A 1 181 ? -29.585 -5.294  -16.559 0.50 57.64  ? 444  GLU   A CB  1 
ATOM   1243 C  CG  . GLU   A 1 181 ? -29.561 -3.912  -15.924 0.50 57.55  ? 444  GLU   A CG  1 
ATOM   1244 C  CD  . GLU   A 1 181 ? -30.374 -3.777  -14.642 0.50 56.67  ? 444  GLU   A CD  1 
ATOM   1245 O  OE1 . GLU   A 1 181 ? -29.947 -3.017  -13.746 0.50 54.57  ? 444  GLU   A OE1 1 
ATOM   1246 O  OE2 . GLU   A 1 181 ? -31.432 -4.433  -14.540 0.50 52.29  ? 444  GLU   A OE2 1 
ATOM   1247 N  N   . GLY   A 1 182 ? -26.605 -6.510  -18.062 0.50 62.51  ? 445  GLY   A N   1 
ATOM   1248 C  CA  . GLY   A 1 182 ? -25.133 -6.653  -18.095 0.50 60.45  ? 445  GLY   A CA  1 
ATOM   1249 C  C   . GLY   A 1 182 ? -24.529 -6.846  -16.712 0.50 59.67  ? 445  GLY   A C   1 
ATOM   1250 O  O   . GLY   A 1 182 ? -23.346 -6.499  -16.532 0.50 61.62  ? 445  GLY   A O   1 
ATOM   1251 N  N   . LYS   A 1 183 ? -25.301 -7.397  -15.772 0.50 57.66  ? 446  LYS   A N   1 
ATOM   1252 C  CA  . LYS   A 1 183 ? -24.890 -7.598  -14.356 0.50 59.51  ? 446  LYS   A CA  1 
ATOM   1253 C  C   . LYS   A 1 183 ? -25.358 -8.983  -13.890 0.50 55.17  ? 446  LYS   A C   1 
ATOM   1254 O  O   . LYS   A 1 183 ? -26.166 -9.604  -14.602 0.50 53.48  ? 446  LYS   A O   1 
ATOM   1255 C  CB  . LYS   A 1 183 ? -25.474 -6.488  -13.474 0.50 64.75  ? 446  LYS   A CB  1 
ATOM   1256 C  CG  . LYS   A 1 183 ? -25.190 -5.066  -13.945 0.50 67.53  ? 446  LYS   A CG  1 
ATOM   1257 C  CD  . LYS   A 1 183 ? -26.176 -4.043  -13.421 0.50 70.58  ? 446  LYS   A CD  1 
ATOM   1258 C  CE  . LYS   A 1 183 ? -26.073 -2.706  -14.125 0.50 72.50  ? 446  LYS   A CE  1 
ATOM   1259 N  NZ  . LYS   A 1 183 ? -27.249 -1.848  -13.842 0.50 74.90  ? 446  LYS   A NZ  1 
ATOM   1260 N  N   . CYS   A 1 184 ? -24.876 -9.430  -12.726 1.00 55.19  ? 447  CYS   A N   1 
ATOM   1261 C  CA  . CYS   A 1 184 ? -25.086 -10.812 -12.199 1.00 58.14  ? 447  CYS   A CA  1 
ATOM   1262 C  C   . CYS   A 1 184 ? -25.351 -10.742 -10.687 1.00 54.92  ? 447  CYS   A C   1 
ATOM   1263 O  O   . CYS   A 1 184 ? -24.628 -9.973  -10.004 1.00 59.47  ? 447  CYS   A O   1 
ATOM   1264 C  CB  . CYS   A 1 184 ? -23.860 -11.688 -12.504 1.00 52.89  ? 447  CYS   A CB  1 
ATOM   1265 S  SG  . CYS   A 1 184 ? -24.094 -13.453 -12.140 1.00 52.73  ? 447  CYS   A SG  1 
ATOM   1266 N  N   . GLU   A 1 185 ? -26.263 -11.567 -10.160 1.00 54.61  ? 448  GLU   A N   1 
ATOM   1267 C  CA  . GLU   A 1 185 ? -26.579 -11.569 -8.702  1.00 62.25  ? 448  GLU   A CA  1 
ATOM   1268 C  C   . GLU   A 1 185 ? -26.367 -12.961 -8.075  1.00 63.62  ? 448  GLU   A C   1 
ATOM   1269 O  O   . GLU   A 1 185 ? -25.862 -13.009 -6.929  1.00 65.22  ? 448  GLU   A O   1 
ATOM   1270 C  CB  . GLU   A 1 185 ? -27.999 -11.013 -8.494  1.00 72.63  ? 448  GLU   A CB  1 
ATOM   1271 C  CG  . GLU   A 1 185 ? -28.321 -10.579 -7.067  1.00 75.46  ? 448  GLU   A CG  1 
ATOM   1272 C  CD  . GLU   A 1 185 ? -29.761 -10.123 -6.872  1.00 84.63  ? 448  GLU   A CD  1 
ATOM   1273 O  OE1 . GLU   A 1 185 ? -30.036 -8.941  -7.164  1.00 80.42  ? 448  GLU   A OE1 1 
ATOM   1274 O  OE2 . GLU   A 1 185 ? -30.616 -10.955 -6.455  1.00 90.30  ? 448  GLU   A OE2 1 
ATOM   1275 N  N   . THR   A 1 186 ? -26.726 -14.050 -8.759  1.00 61.65  ? 449  THR   A N   1 
ATOM   1276 C  CA  . THR   A 1 186 ? -26.943 -15.380 -8.125  1.00 65.40  ? 449  THR   A CA  1 
ATOM   1277 C  C   . THR   A 1 186 ? -26.086 -16.483 -8.762  1.00 58.58  ? 449  THR   A C   1 
ATOM   1278 O  O   . THR   A 1 186 ? -26.148 -17.608 -8.255  1.00 69.06  ? 449  THR   A O   1 
ATOM   1279 C  CB  . THR   A 1 186 ? -28.429 -15.756 -8.164  1.00 68.00  ? 449  THR   A CB  1 
ATOM   1280 O  OG1 . THR   A 1 186 ? -28.824 -16.018 -9.507  1.00 71.19  ? 449  THR   A OG1 1 
ATOM   1281 C  CG2 . THR   A 1 186 ? -29.322 -14.674 -7.603  1.00 75.20  ? 449  THR   A CG2 1 
ATOM   1282 N  N   . CYS   A 1 187 ? -25.324 -16.194 -9.818  1.00 59.18  ? 450  CYS   A N   1 
ATOM   1283 C  CA  . CYS   A 1 187 ? -24.459 -17.183 -10.521 1.00 51.99  ? 450  CYS   A CA  1 
ATOM   1284 C  C   . CYS   A 1 187 ? -23.113 -17.305 -9.785  1.00 50.87  ? 450  CYS   A C   1 
ATOM   1285 O  O   . CYS   A 1 187 ? -22.105 -16.731 -10.237 1.00 45.34  ? 450  CYS   A O   1 
ATOM   1286 C  CB  . CYS   A 1 187 ? -24.341 -16.811 -11.990 1.00 51.47  ? 450  CYS   A CB  1 
ATOM   1287 S  SG  . CYS   A 1 187 ? -25.976 -16.586 -12.750 1.00 55.17  ? 450  CYS   A SG  1 
ATOM   1288 N  N   . VAL   A 1 188 ? -23.122 -18.098 -8.710  1.00 56.69  ? 451  VAL   A N   1 
ATOM   1289 C  CA  . VAL   A 1 188 ? -21.989 -18.357 -7.775  1.00 61.32  ? 451  VAL   A CA  1 
ATOM   1290 C  C   . VAL   A 1 188 ? -21.655 -19.856 -7.769  1.00 58.72  ? 451  VAL   A C   1 
ATOM   1291 O  O   . VAL   A 1 188 ? -22.581 -20.692 -7.667  1.00 57.77  ? 451  VAL   A O   1 
ATOM   1292 C  CB  . VAL   A 1 188 ? -22.359 -17.887 -6.356  1.00 65.15  ? 451  VAL   A CB  1 
ATOM   1293 C  CG1 . VAL   A 1 188 ? -21.380 -18.404 -5.307  1.00 70.27  ? 451  VAL   A CG1 1 
ATOM   1294 C  CG2 . VAL   A 1 188 ? -22.482 -16.374 -6.295  1.00 68.80  ? 451  VAL   A CG2 1 
ATOM   1295 N  N   . TYR   A 1 189 ? -20.370 -20.189 -7.811  1.00 59.11  ? 452  TYR   A N   1 
ATOM   1296 C  CA  . TYR   A 1 189 ? -19.898 -21.598 -7.829  1.00 64.21  ? 452  TYR   A CA  1 
ATOM   1297 C  C   . TYR   A 1 189 ? -19.731 -22.135 -6.401  1.00 61.38  ? 452  TYR   A C   1 
ATOM   1298 O  O   . TYR   A 1 189 ? -19.517 -21.338 -5.482  1.00 63.23  ? 452  TYR   A O   1 
ATOM   1299 C  CB  . TYR   A 1 189 ? -18.600 -21.687 -8.620  1.00 64.90  ? 452  TYR   A CB  1 
ATOM   1300 C  CG  . TYR   A 1 189 ? -18.768 -21.524 -10.103 1.00 61.33  ? 452  TYR   A CG  1 
ATOM   1301 C  CD1 . TYR   A 1 189 ? -19.357 -22.514 -10.868 1.00 67.59  ? 452  TYR   A CD1 1 
ATOM   1302 C  CD2 . TYR   A 1 189 ? -18.324 -20.381 -10.742 1.00 64.18  ? 452  TYR   A CD2 1 
ATOM   1303 C  CE1 . TYR   A 1 189 ? -19.507 -22.368 -12.238 1.00 72.16  ? 452  TYR   A CE1 1 
ATOM   1304 C  CE2 . TYR   A 1 189 ? -18.448 -20.225 -12.112 1.00 66.54  ? 452  TYR   A CE2 1 
ATOM   1305 C  CZ  . TYR   A 1 189 ? -19.044 -21.221 -12.861 1.00 70.35  ? 452  TYR   A CZ  1 
ATOM   1306 O  OH  . TYR   A 1 189 ? -19.189 -21.051 -14.206 1.00 79.08  ? 452  TYR   A OH  1 
ATOM   1307 N  N   . ASN   A 1 190 ? -19.872 -23.455 -6.232  1.00 70.91  ? 453  ASN   A N   1 
ATOM   1308 C  CA  . ASN   A 1 190 ? -19.538 -24.214 -4.990  1.00 75.24  ? 453  ASN   A CA  1 
ATOM   1309 C  C   . ASN   A 1 190 ? -18.522 -25.318 -5.301  1.00 74.65  ? 453  ASN   A C   1 
ATOM   1310 O  O   . ASN   A 1 190 ? -18.900 -26.236 -6.026  1.00 73.94  ? 453  ASN   A O   1 
ATOM   1311 C  CB  . ASN   A 1 190 ? -20.790 -24.821 -4.366  1.00 68.55  ? 453  ASN   A CB  1 
ATOM   1312 C  CG  . ASN   A 1 190 ? -21.836 -23.758 -4.140  1.00 66.02  ? 453  ASN   A CG  1 
ATOM   1313 O  OD1 . ASN   A 1 190 ? -21.769 -22.705 -4.753  1.00 65.84  ? 453  ASN   A OD1 1 
ATOM   1314 N  ND2 . ASN   A 1 190 ? -22.784 -24.009 -3.256  1.00 64.63  ? 453  ASN   A ND2 1 
ATOM   1315 N  N   . MET   A 1 191 ? -17.300 -25.233 -4.760  1.00 87.57  ? 454  MET   A N   1 
ATOM   1316 C  CA  . MET   A 1 191 ? -16.178 -26.152 -5.096  1.00 97.73  ? 454  MET   A CA  1 
ATOM   1317 C  C   . MET   A 1 191 ? -16.295 -27.427 -4.257  1.00 102.13 ? 454  MET   A C   1 
ATOM   1318 O  O   . MET   A 1 191 ? -16.739 -27.312 -3.110  1.00 97.15  ? 454  MET   A O   1 
ATOM   1319 C  CB  . MET   A 1 191 ? -14.822 -25.497 -4.826  1.00 107.55 ? 454  MET   A CB  1 
ATOM   1320 C  CG  . MET   A 1 191 ? -13.658 -26.310 -5.370  1.00 123.38 ? 454  MET   A CG  1 
ATOM   1321 S  SD  . MET   A 1 191 ? -12.132 -25.359 -5.600  1.00 141.62 ? 454  MET   A SD  1 
ATOM   1322 C  CE  . MET   A 1 191 ? -12.688 -24.170 -6.816  1.00 134.41 ? 454  MET   A CE  1 
ATOM   1323 N  N   . MET   A 1 192 ? -15.904 -28.580 -4.823  1.00 117.83 ? 455  MET   A N   1 
ATOM   1324 C  CA  . MET   A 1 192 ? -15.920 -29.926 -4.172  1.00 115.49 ? 455  MET   A CA  1 
ATOM   1325 C  C   . MET   A 1 192 ? -15.129 -30.931 -5.022  1.00 115.12 ? 455  MET   A C   1 
ATOM   1326 O  O   . MET   A 1 192 ? -15.658 -31.339 -6.085  1.00 95.70  ? 455  MET   A O   1 
ATOM   1327 C  CB  . MET   A 1 192 ? -17.354 -30.439 -3.994  1.00 116.96 ? 455  MET   A CB  1 
ATOM   1328 C  CG  . MET   A 1 192 ? -17.943 -30.161 -2.624  1.00 110.81 ? 455  MET   A CG  1 
ATOM   1329 S  SD  . MET   A 1 192 ? -19.750 -30.036 -2.669  1.00 117.40 ? 455  MET   A SD  1 
ATOM   1330 C  CE  . MET   A 1 192 ? -20.209 -31.754 -2.904  1.00 113.50 ? 455  MET   A CE  1 
ATOM   1331 N  N   . ALA   A 1 210 ? -11.629 -31.105 -7.951  0.50 111.55 ? 473  ALA   A N   1 
ATOM   1332 C  CA  . ALA   A 1 210 ? -12.479 -29.950 -7.574  0.50 109.96 ? 473  ALA   A CA  1 
ATOM   1333 C  C   . ALA   A 1 210 ? -13.544 -29.711 -8.655  0.50 106.90 ? 473  ALA   A C   1 
ATOM   1334 O  O   . ALA   A 1 210 ? -13.212 -29.089 -9.686  0.50 108.33 ? 473  ALA   A O   1 
ATOM   1335 C  CB  . ALA   A 1 210 ? -11.613 -28.730 -7.364  0.50 107.66 ? 473  ALA   A CB  1 
ATOM   1336 N  N   . ILE   A 1 211 ? -14.773 -30.191 -8.420  0.50 101.43 ? 474  ILE   A N   1 
ATOM   1337 C  CA  . ILE   A 1 211 ? -15.955 -30.033 -9.324  0.50 97.52  ? 474  ILE   A CA  1 
ATOM   1338 C  C   . ILE   A 1 211 ? -16.932 -29.033 -8.693  0.50 94.31  ? 474  ILE   A C   1 
ATOM   1339 O  O   . ILE   A 1 211 ? -17.448 -29.330 -7.595  0.50 92.48  ? 474  ILE   A O   1 
ATOM   1340 C  CB  . ILE   A 1 211 ? -16.636 -31.392 -9.588  0.50 96.60  ? 474  ILE   A CB  1 
ATOM   1341 C  CG1 . ILE   A 1 211 ? -15.738 -32.340 -10.389 0.50 97.85  ? 474  ILE   A CG1 1 
ATOM   1342 C  CG2 . ILE   A 1 211 ? -17.987 -31.194 -10.260 0.50 94.04  ? 474  ILE   A CG2 1 
ATOM   1343 C  CD1 . ILE   A 1 211 ? -14.599 -32.939 -9.591  0.50 96.60  ? 474  ILE   A CD1 1 
ATOM   1344 N  N   . TRP   A 1 212 ? -17.190 -27.908 -9.370  0.50 88.80  ? 475  TRP   A N   1 
ATOM   1345 C  CA  . TRP   A 1 212 ? -18.000 -26.779 -8.838  0.50 83.91  ? 475  TRP   A CA  1 
ATOM   1346 C  C   . TRP   A 1 212 ? -19.469 -26.934 -9.248  0.50 82.31  ? 475  TRP   A C   1 
ATOM   1347 O  O   . TRP   A 1 212 ? -19.733 -27.072 -10.455 0.50 83.29  ? 475  TRP   A O   1 
ATOM   1348 C  CB  . TRP   A 1 212 ? -17.434 -25.429 -9.294  0.50 79.38  ? 475  TRP   A CB  1 
ATOM   1349 C  CG  . TRP   A 1 212 ? -15.942 -25.396 -9.404  0.50 77.12  ? 475  TRP   A CG  1 
ATOM   1350 C  CD1 . TRP   A 1 212 ? -15.062 -26.332 -8.944  0.50 76.38  ? 475  TRP   A CD1 1 
ATOM   1351 C  CD2 . TRP   A 1 212 ? -15.145 -24.355 -9.996  0.50 74.75  ? 475  TRP   A CD2 1 
ATOM   1352 N  NE1 . TRP   A 1 212 ? -13.777 -25.957 -9.227  0.50 75.29  ? 475  TRP   A NE1 1 
ATOM   1353 C  CE2 . TRP   A 1 212 ? -13.796 -24.748 -9.870  0.50 74.48  ? 475  TRP   A CE2 1 
ATOM   1354 C  CE3 . TRP   A 1 212 ? -15.436 -23.139 -10.623 0.50 72.32  ? 475  TRP   A CE3 1 
ATOM   1355 C  CZ2 . TRP   A 1 212 ? -12.746 -23.964 -10.345 0.50 74.97  ? 475  TRP   A CZ2 1 
ATOM   1356 C  CZ3 . TRP   A 1 212 ? -14.398 -22.368 -11.097 0.50 72.79  ? 475  TRP   A CZ3 1 
ATOM   1357 C  CH2 . TRP   A 1 212 ? -13.072 -22.778 -10.961 0.50 73.94  ? 475  TRP   A CH2 1 
ATOM   1358 N  N   . TYR   A 1 213 ? -20.379 -26.897 -8.269  0.50 81.75  ? 476  TYR   A N   1 
ATOM   1359 C  CA  . TYR   A 1 213 ? -21.853 -26.859 -8.460  0.50 82.46  ? 476  TYR   A CA  1 
ATOM   1360 C  C   . TYR   A 1 213 ? -22.326 -25.404 -8.557  0.50 79.93  ? 476  TYR   A C   1 
ATOM   1361 O  O   . TYR   A 1 213 ? -21.784 -24.540 -7.838  0.50 80.90  ? 476  TYR   A O   1 
ATOM   1362 C  CB  . TYR   A 1 213 ? -22.583 -27.528 -7.292  0.50 86.14  ? 476  TYR   A CB  1 
ATOM   1363 C  CG  . TYR   A 1 213 ? -22.373 -29.014 -7.143  0.50 88.58  ? 476  TYR   A CG  1 
ATOM   1364 C  CD1 . TYR   A 1 213 ? -23.303 -29.920 -7.626  0.50 90.86  ? 476  TYR   A CD1 1 
ATOM   1365 C  CD2 . TYR   A 1 213 ? -21.264 -29.517 -6.484  0.50 91.36  ? 476  TYR   A CD2 1 
ATOM   1366 C  CE1 . TYR   A 1 213 ? -23.126 -31.286 -7.479  0.50 93.36  ? 476  TYR   A CE1 1 
ATOM   1367 C  CE2 . TYR   A 1 213 ? -21.072 -30.880 -6.326  0.50 92.22  ? 476  TYR   A CE2 1 
ATOM   1368 C  CZ  . TYR   A 1 213 ? -22.007 -31.769 -6.826  0.50 93.74  ? 476  TYR   A CZ  1 
ATOM   1369 O  OH  . TYR   A 1 213 ? -21.824 -33.114 -6.677  0.50 95.10  ? 476  TYR   A OH  1 
ATOM   1370 N  N   . MET   A 1 214 ? -23.302 -25.148 -9.432  0.50 76.64  ? 477  MET   A N   1 
ATOM   1371 C  CA  . MET   A 1 214 ? -24.161 -23.932 -9.426  0.50 73.42  ? 477  MET   A CA  1 
ATOM   1372 C  C   . MET   A 1 214 ? -25.583 -24.392 -9.108  0.50 66.43  ? 477  MET   A C   1 
ATOM   1373 O  O   . MET   A 1 214 ? -25.850 -25.591 -9.297  0.50 64.48  ? 477  MET   A O   1 
ATOM   1374 C  CB  . MET   A 1 214 ? -24.165 -23.227 -10.785 0.50 74.72  ? 477  MET   A CB  1 
ATOM   1375 C  CG  . MET   A 1 214 ? -22.833 -22.625 -11.187 0.50 77.09  ? 477  MET   A CG  1 
ATOM   1376 S  SD  . MET   A 1 214 ? -22.844 -22.095 -12.923 0.50 78.68  ? 477  MET   A SD  1 
ATOM   1377 C  CE  . MET   A 1 214 ? -22.278 -20.403 -12.756 0.50 78.21  ? 477  MET   A CE  1 
ATOM   1378 N  N   . TRP   A 1 215 ? -26.461 -23.493 -8.659  0.50 64.16  ? 478  TRP   A N   1 
ATOM   1379 C  CA  . TRP   A 1 215 ? -27.890 -23.834 -8.429  0.50 63.84  ? 478  TRP   A CA  1 
ATOM   1380 C  C   . TRP   A 1 215 ? -28.615 -23.890 -9.781  0.50 61.74  ? 478  TRP   A C   1 
ATOM   1381 O  O   . TRP   A 1 215 ? -28.135 -23.252 -10.736 0.50 59.08  ? 478  TRP   A O   1 
ATOM   1382 C  CB  . TRP   A 1 215 ? -28.548 -22.872 -7.435  0.50 62.09  ? 478  TRP   A CB  1 
ATOM   1383 C  CG  . TRP   A 1 215 ? -28.974 -21.560 -8.013  0.50 62.85  ? 478  TRP   A CG  1 
ATOM   1384 C  CD1 . TRP   A 1 215 ? -28.173 -20.502 -8.328  0.50 63.16  ? 478  TRP   A CD1 1 
ATOM   1385 C  CD2 . TRP   A 1 215 ? -30.321 -21.149 -8.304  0.50 61.76  ? 478  TRP   A CD2 1 
ATOM   1386 N  NE1 . TRP   A 1 215 ? -28.927 -19.465 -8.810  0.50 64.15  ? 478  TRP   A NE1 1 
ATOM   1387 C  CE2 . TRP   A 1 215 ? -30.248 -19.832 -8.806  0.50 63.81  ? 478  TRP   A CE2 1 
ATOM   1388 C  CE3 . TRP   A 1 215 ? -31.574 -21.762 -8.192  0.50 61.43  ? 478  TRP   A CE3 1 
ATOM   1389 C  CZ2 . TRP   A 1 215 ? -31.382 -19.123 -9.201  0.50 63.42  ? 478  TRP   A CZ2 1 
ATOM   1390 C  CZ3 . TRP   A 1 215 ? -32.692 -21.063 -8.587  0.50 61.65  ? 478  TRP   A CZ3 1 
ATOM   1391 C  CH2 . TRP   A 1 215 ? -32.595 -19.761 -9.082  0.50 63.55  ? 478  TRP   A CH2 1 
ATOM   1392 N  N   . LEU   A 1 216 ? -29.702 -24.663 -9.850  1.00 62.54  ? 479  LEU   A N   1 
ATOM   1393 C  CA  . LEU   A 1 216 ? -30.381 -25.049 -11.115 1.00 62.03  ? 479  LEU   A CA  1 
ATOM   1394 C  C   . LEU   A 1 216 ? -30.622 -23.848 -12.028 1.00 63.29  ? 479  LEU   A C   1 
ATOM   1395 O  O   . LEU   A 1 216 ? -30.384 -23.979 -13.228 1.00 68.81  ? 479  LEU   A O   1 
ATOM   1396 C  CB  . LEU   A 1 216 ? -31.712 -25.694 -10.749 1.00 64.91  ? 479  LEU   A CB  1 
ATOM   1397 C  CG  . LEU   A 1 216 ? -32.260 -26.648 -11.794 1.00 71.01  ? 479  LEU   A CG  1 
ATOM   1398 C  CD1 . LEU   A 1 216 ? -31.299 -27.807 -12.016 1.00 74.72  ? 479  LEU   A CD1 1 
ATOM   1399 C  CD2 . LEU   A 1 216 ? -33.633 -27.145 -11.377 1.00 73.17  ? 479  LEU   A CD2 1 
ATOM   1400 N  N   . GLY   A 1 217 ? -31.056 -22.727 -11.457 1.00 61.84  ? 480  GLY   A N   1 
ATOM   1401 C  CA  . GLY   A 1 217 ? -31.317 -21.471 -12.174 1.00 62.71  ? 480  GLY   A CA  1 
ATOM   1402 C  C   . GLY   A 1 217 ? -30.140 -21.021 -13.013 1.00 57.76  ? 480  GLY   A C   1 
ATOM   1403 O  O   . GLY   A 1 217 ? -30.347 -20.742 -14.213 1.00 58.17  ? 480  GLY   A O   1 
ATOM   1404 N  N   . ALA   A 1 218 ? -28.949 -20.927 -12.422 1.00 53.61  ? 481  ALA   A N   1 
ATOM   1405 C  CA  . ALA   A 1 218 ? -27.736 -20.473 -13.147 1.00 54.06  ? 481  ALA   A CA  1 
ATOM   1406 C  C   . ALA   A 1 218 ? -27.330 -21.527 -14.194 1.00 50.85  ? 481  ALA   A C   1 
ATOM   1407 O  O   . ALA   A 1 218 ? -26.809 -21.120 -15.244 1.00 44.59  ? 481  ALA   A O   1 
ATOM   1408 C  CB  . ALA   A 1 218 ? -26.629 -20.181 -12.186 1.00 48.60  ? 481  ALA   A CB  1 
ATOM   1409 N  N   . ARG   A 1 219 ? -27.590 -22.816 -13.931 1.00 51.82  ? 482  ARG   A N   1 
ATOM   1410 C  CA  . ARG   A 1 219 ? -27.356 -23.931 -14.890 1.00 56.69  ? 482  ARG   A CA  1 
ATOM   1411 C  C   . ARG   A 1 219 ? -28.250 -23.738 -16.106 1.00 55.59  ? 482  ARG   A C   1 
ATOM   1412 O  O   . ARG   A 1 219 ? -27.770 -23.996 -17.222 1.00 48.82  ? 482  ARG   A O   1 
ATOM   1413 C  CB  . ARG   A 1 219 ? -27.638 -25.323 -14.320 1.00 58.25  ? 482  ARG   A CB  1 
ATOM   1414 C  CG  . ARG   A 1 219 ? -26.388 -26.184 -14.248 1.00 74.47  ? 482  ARG   A CG  1 
ATOM   1415 C  CD  . ARG   A 1 219 ? -25.486 -25.606 -13.166 1.00 86.80  ? 482  ARG   A CD  1 
ATOM   1416 N  NE  . ARG   A 1 219 ? -24.086 -26.029 -13.038 1.00 86.27  ? 482  ARG   A NE  1 
ATOM   1417 C  CZ  . ARG   A 1 219 ? -23.028 -25.426 -13.589 1.00 86.11  ? 482  ARG   A CZ  1 
ATOM   1418 N  NH1 . ARG   A 1 219 ? -23.168 -24.390 -14.401 1.00 87.50  ? 482  ARG   A NH1 1 
ATOM   1419 N  NH2 . ARG   A 1 219 ? -21.814 -25.879 -13.328 1.00 96.01  ? 482  ARG   A NH2 1 
ATOM   1420 N  N   . PHE   A 1 220 ? -29.499 -23.319 -15.885 1.00 52.82  ? 483  PHE   A N   1 
ATOM   1421 C  CA  . PHE   A 1 220 ? -30.466 -23.067 -16.976 1.00 47.96  ? 483  PHE   A CA  1 
ATOM   1422 C  C   . PHE   A 1 220 ? -29.889 -22.011 -17.913 1.00 42.31  ? 483  PHE   A C   1 
ATOM   1423 O  O   . PHE   A 1 220 ? -29.863 -22.253 -19.109 1.00 48.06  ? 483  PHE   A O   1 
ATOM   1424 C  CB  . PHE   A 1 220 ? -31.840 -22.605 -16.488 1.00 43.69  ? 483  PHE   A CB  1 
ATOM   1425 C  CG  . PHE   A 1 220 ? -32.714 -22.297 -17.670 1.00 40.59  ? 483  PHE   A CG  1 
ATOM   1426 C  CD1 . PHE   A 1 220 ? -33.095 -23.309 -18.528 1.00 43.13  ? 483  PHE   A CD1 1 
ATOM   1427 C  CD2 . PHE   A 1 220 ? -32.999 -20.990 -18.020 1.00 45.88  ? 483  PHE   A CD2 1 
ATOM   1428 C  CE1 . PHE   A 1 220 ? -33.830 -23.030 -19.669 1.00 52.16  ? 483  PHE   A CE1 1 
ATOM   1429 C  CE2 . PHE   A 1 220 ? -33.726 -20.706 -19.173 1.00 48.05  ? 483  PHE   A CE2 1 
ATOM   1430 C  CZ  . PHE   A 1 220 ? -34.154 -21.729 -19.986 1.00 49.50  ? 483  PHE   A CZ  1 
ATOM   1431 N  N   . LEU   A 1 221 ? -29.489 -20.863 -17.373 1.00 49.15  ? 484  LEU   A N   1 
ATOM   1432 C  CA  . LEU   A 1 221 ? -29.002 -19.704 -18.169 1.00 51.41  ? 484  LEU   A CA  1 
ATOM   1433 C  C   . LEU   A 1 221 ? -27.713 -20.086 -18.911 1.00 48.32  ? 484  LEU   A C   1 
ATOM   1434 O  O   . LEU   A 1 221 ? -27.548 -19.670 -20.079 1.00 45.36  ? 484  LEU   A O   1 
ATOM   1435 C  CB  . LEU   A 1 221 ? -28.789 -18.506 -17.240 1.00 52.37  ? 484  LEU   A CB  1 
ATOM   1436 C  CG  . LEU   A 1 221 ? -30.058 -17.798 -16.759 1.00 56.23  ? 484  LEU   A CG  1 
ATOM   1437 C  CD1 . LEU   A 1 221 ? -29.695 -16.562 -15.953 1.00 58.97  ? 484  LEU   A CD1 1 
ATOM   1438 C  CD2 . LEU   A 1 221 ? -30.960 -17.399 -17.918 1.00 53.30  ? 484  LEU   A CD2 1 
ATOM   1439 N  N   . GLU   A 1 222 ? -26.842 -20.883 -18.293 1.00 48.28  ? 485  GLU   A N   1 
ATOM   1440 C  CA  . GLU   A 1 222 ? -25.655 -21.426 -19.005 1.00 47.51  ? 485  GLU   A CA  1 
ATOM   1441 C  C   . GLU   A 1 222 ? -26.133 -22.300 -20.194 1.00 42.82  ? 485  GLU   A C   1 
ATOM   1442 O  O   . GLU   A 1 222 ? -25.630 -22.098 -21.311 1.00 42.11  ? 485  GLU   A O   1 
ATOM   1443 C  CB  . GLU   A 1 222 ? -24.726 -22.155 -18.029 1.00 44.41  ? 485  GLU   A CB  1 
ATOM   1444 C  CG  . GLU   A 1 222 ? -23.662 -22.915 -18.776 1.00 52.51  ? 485  GLU   A CG  1 
ATOM   1445 C  CD  . GLU   A 1 222 ? -22.713 -23.728 -17.937 1.00 54.01  ? 485  GLU   A CD  1 
ATOM   1446 O  OE1 . GLU   A 1 222 ? -21.551 -23.287 -17.763 1.00 52.30  ? 485  GLU   A OE1 1 
ATOM   1447 O  OE2 . GLU   A 1 222 ? -23.128 -24.809 -17.523 1.00 58.06  ? 485  GLU   A OE2 1 
ATOM   1448 N  N   . PHE   A 1 223 ? -27.084 -23.215 -19.971 1.00 41.81  ? 486  PHE   A N   1 
ATOM   1449 C  CA  . PHE   A 1 223 ? -27.654 -24.166 -20.966 1.00 46.27  ? 486  PHE   A CA  1 
ATOM   1450 C  C   . PHE   A 1 223 ? -28.365 -23.454 -22.112 1.00 49.22  ? 486  PHE   A C   1 
ATOM   1451 O  O   . PHE   A 1 223 ? -28.255 -23.889 -23.281 1.00 45.57  ? 486  PHE   A O   1 
ATOM   1452 C  CB  . PHE   A 1 223 ? -28.723 -25.030 -20.313 1.00 46.23  ? 486  PHE   A CB  1 
ATOM   1453 C  CG  . PHE   A 1 223 ? -29.395 -26.026 -21.213 1.00 47.82  ? 486  PHE   A CG  1 
ATOM   1454 C  CD1 . PHE   A 1 223 ? -28.690 -27.105 -21.728 1.00 47.61  ? 486  PHE   A CD1 1 
ATOM   1455 C  CD2 . PHE   A 1 223 ? -30.756 -25.930 -21.473 1.00 47.28  ? 486  PHE   A CD2 1 
ATOM   1456 C  CE1 . PHE   A 1 223 ? -29.325 -28.022 -22.558 1.00 50.39  ? 486  PHE   A CE1 1 
ATOM   1457 C  CE2 . PHE   A 1 223 ? -31.395 -26.871 -22.266 1.00 45.90  ? 486  PHE   A CE2 1 
ATOM   1458 C  CZ  . PHE   A 1 223 ? -30.680 -27.907 -22.822 1.00 48.55  ? 486  PHE   A CZ  1 
ATOM   1459 N  N   . GLU   A 1 224 ? -29.108 -22.394 -21.775 0.50 49.37  ? 487  GLU   A N   1 
ATOM   1460 C  CA  . GLU   A 1 224 ? -29.883 -21.552 -22.727 0.50 50.49  ? 487  GLU   A CA  1 
ATOM   1461 C  C   . GLU   A 1 224 ? -28.921 -20.924 -23.741 0.50 49.20  ? 487  GLU   A C   1 
ATOM   1462 O  O   . GLU   A 1 224 ? -29.257 -20.891 -24.949 0.50 48.48  ? 487  GLU   A O   1 
ATOM   1463 C  CB  . GLU   A 1 224 ? -30.654 -20.462 -21.974 0.50 52.35  ? 487  GLU   A CB  1 
ATOM   1464 C  CG  . GLU   A 1 224 ? -31.365 -19.473 -22.885 0.50 52.04  ? 487  GLU   A CG  1 
ATOM   1465 C  CD  . GLU   A 1 224 ? -32.194 -18.408 -22.180 0.50 51.49  ? 487  GLU   A CD  1 
ATOM   1466 O  OE1 . GLU   A 1 224 ? -33.398 -18.290 -22.503 0.50 48.44  ? 487  GLU   A OE1 1 
ATOM   1467 O  OE2 . GLU   A 1 224 ? -31.634 -17.686 -21.326 0.50 49.29  ? 487  GLU   A OE2 1 
ATOM   1468 N  N   . ALA   A 1 225 ? -27.768 -20.452 -23.264 1.00 45.88  ? 488  ALA   A N   1 
ATOM   1469 C  CA  . ALA   A 1 225 ? -26.806 -19.690 -24.083 1.00 44.04  ? 488  ALA   A CA  1 
ATOM   1470 C  C   . ALA   A 1 225 ? -25.890 -20.639 -24.861 1.00 41.57  ? 488  ALA   A C   1 
ATOM   1471 O  O   . ALA   A 1 225 ? -25.550 -20.253 -26.017 1.00 41.32  ? 488  ALA   A O   1 
ATOM   1472 C  CB  . ALA   A 1 225 ? -26.060 -18.735 -23.209 1.00 41.88  ? 488  ALA   A CB  1 
ATOM   1473 N  N   . LEU   A 1 226 ? -25.536 -21.811 -24.301 1.00 37.46  ? 489  LEU   A N   1 
ATOM   1474 C  CA  . LEU   A 1 226 ? -24.360 -22.600 -24.781 1.00 37.11  ? 489  LEU   A CA  1 
ATOM   1475 C  C   . LEU   A 1 226 ? -24.669 -24.085 -24.964 1.00 35.07  ? 489  LEU   A C   1 
ATOM   1476 O  O   . LEU   A 1 226 ? -23.796 -24.800 -25.528 1.00 35.47  ? 489  LEU   A O   1 
ATOM   1477 C  CB  . LEU   A 1 226 ? -23.187 -22.386 -23.822 1.00 35.48  ? 489  LEU   A CB  1 
ATOM   1478 C  CG  . LEU   A 1 226 ? -22.709 -20.936 -23.710 1.00 40.57  ? 489  LEU   A CG  1 
ATOM   1479 C  CD1 . LEU   A 1 226 ? -21.596 -20.753 -22.669 1.00 42.91  ? 489  LEU   A CD1 1 
ATOM   1480 C  CD2 . LEU   A 1 226 ? -22.209 -20.428 -25.052 1.00 44.89  ? 489  LEU   A CD2 1 
ATOM   1481 N  N   . GLY   A 1 227 ? -25.843 -24.560 -24.560 1.00 31.80  ? 490  GLY   A N   1 
ATOM   1482 C  CA  . GLY   A 1 227 ? -26.228 -25.984 -24.698 1.00 30.65  ? 490  GLY   A CA  1 
ATOM   1483 C  C   . GLY   A 1 227 ? -26.228 -26.447 -26.136 1.00 29.12  ? 490  GLY   A C   1 
ATOM   1484 O  O   . GLY   A 1 227 ? -26.097 -27.674 -26.412 1.00 31.21  ? 490  GLY   A O   1 
ATOM   1485 N  N   . PHE   A 1 228 ? -26.383 -25.521 -27.077 1.00 33.49  ? 491  PHE   A N   1 
ATOM   1486 C  CA  . PHE   A 1 228 ? -26.403 -25.893 -28.512 1.00 36.07  ? 491  PHE   A CA  1 
ATOM   1487 C  C   . PHE   A 1 228 ? -25.103 -26.626 -28.874 1.00 33.81  ? 491  PHE   A C   1 
ATOM   1488 O  O   . PHE   A 1 228 ? -25.174 -27.464 -29.762 1.00 34.08  ? 491  PHE   A O   1 
ATOM   1489 C  CB  . PHE   A 1 228 ? -26.632 -24.703 -29.439 1.00 32.55  ? 491  PHE   A CB  1 
ATOM   1490 C  CG  . PHE   A 1 228 ? -25.495 -23.745 -29.524 1.00 29.26  ? 491  PHE   A CG  1 
ATOM   1491 C  CD1 . PHE   A 1 228 ? -25.377 -22.711 -28.613 1.00 34.34  ? 491  PHE   A CD1 1 
ATOM   1492 C  CD2 . PHE   A 1 228 ? -24.524 -23.886 -30.495 1.00 32.91  ? 491  PHE   A CD2 1 
ATOM   1493 C  CE1 . PHE   A 1 228 ? -24.321 -21.818 -28.688 1.00 31.06  ? 491  PHE   A CE1 1 
ATOM   1494 C  CE2 . PHE   A 1 228 ? -23.447 -23.011 -30.555 1.00 31.40  ? 491  PHE   A CE2 1 
ATOM   1495 C  CZ  . PHE   A 1 228 ? -23.332 -21.988 -29.639 1.00 32.79  ? 491  PHE   A CZ  1 
ATOM   1496 N  N   . LEU   A 1 229 ? -23.965 -26.268 -28.266 1.00 36.21  ? 492  LEU   A N   1 
ATOM   1497 C  CA  . LEU   A 1 229 ? -22.646 -26.890 -28.567 1.00 37.06  ? 492  LEU   A CA  1 
ATOM   1498 C  C   . LEU   A 1 229 ? -22.769 -28.406 -28.417 1.00 33.30  ? 492  LEU   A C   1 
ATOM   1499 O  O   . LEU   A 1 229 ? -22.354 -29.152 -29.358 1.00 34.47  ? 492  LEU   A O   1 
ATOM   1500 C  CB  . LEU   A 1 229 ? -21.573 -26.304 -27.634 1.00 37.64  ? 492  LEU   A CB  1 
ATOM   1501 C  CG  . LEU   A 1 229 ? -21.102 -24.884 -27.968 1.00 37.99  ? 492  LEU   A CG  1 
ATOM   1502 C  CD1 . LEU   A 1 229 ? -20.134 -24.399 -26.917 1.00 39.93  ? 492  LEU   A CD1 1 
ATOM   1503 C  CD2 . LEU   A 1 229 ? -20.466 -24.810 -29.360 1.00 39.68  ? 492  LEU   A CD2 1 
ATOM   1504 N  N   . ASN   A 1 230 ? -23.371 -28.843 -27.310 1.00 33.27  ? 493  ASN   A N   1 
ATOM   1505 C  CA  . ASN   A 1 230 ? -23.596 -30.289 -27.044 1.00 35.76  ? 493  ASN   A CA  1 
ATOM   1506 C  C   . ASN   A 1 230 ? -24.891 -30.769 -27.708 1.00 35.93  ? 493  ASN   A C   1 
ATOM   1507 O  O   . ASN   A 1 230 ? -24.840 -31.791 -28.460 1.00 37.25  ? 493  ASN   A O   1 
ATOM   1508 C  CB  . ASN   A 1 230 ? -23.638 -30.577 -25.545 1.00 40.34  ? 493  ASN   A CB  1 
ATOM   1509 C  CG  . ASN   A 1 230 ? -23.772 -32.066 -25.298 1.00 48.02  ? 493  ASN   A CG  1 
ATOM   1510 O  OD1 . ASN   A 1 230 ? -24.796 -32.536 -24.784 1.00 50.69  ? 493  ASN   A OD1 1 
ATOM   1511 N  ND2 . ASN   A 1 230 ? -22.757 -32.818 -25.711 1.00 45.03  ? 493  ASN   A ND2 1 
ATOM   1512 N  N   . GLU   A 1 231 ? -26.024 -30.103 -27.444 1.00 36.44  ? 494  GLU   A N   1 
ATOM   1513 C  CA  . GLU   A 1 231 ? -27.354 -30.538 -27.984 1.00 35.93  ? 494  GLU   A CA  1 
ATOM   1514 C  C   . GLU   A 1 231 ? -27.331 -30.710 -29.525 1.00 36.22  ? 494  GLU   A C   1 
ATOM   1515 O  O   . GLU   A 1 231 ? -28.004 -31.644 -29.986 1.00 34.26  ? 494  GLU   A O   1 
ATOM   1516 C  CB  . GLU   A 1 231 ? -28.456 -29.537 -27.622 1.00 36.78  ? 494  GLU   A CB  1 
ATOM   1517 C  CG  . GLU   A 1 231 ? -28.860 -29.533 -26.155 1.00 40.02  ? 494  GLU   A CG  1 
ATOM   1518 C  CD  . GLU   A 1 231 ? -29.226 -30.893 -25.584 1.00 49.45  ? 494  GLU   A CD  1 
ATOM   1519 O  OE1 . GLU   A 1 231 ? -30.145 -31.551 -26.141 1.00 52.89  ? 494  GLU   A OE1 1 
ATOM   1520 O  OE2 . GLU   A 1 231 ? -28.548 -31.318 -24.615 1.00 61.25  ? 494  GLU   A OE2 1 
ATOM   1521 N  N   . ASP   A 1 232 ? -26.581 -29.882 -30.293 1.00 32.93  ? 495  ASP   A N   1 
ATOM   1522 C  CA  . ASP   A 1 232 ? -26.523 -29.919 -31.781 1.00 30.65  ? 495  ASP   A CA  1 
ATOM   1523 C  C   . ASP   A 1 232 ? -25.165 -30.491 -32.258 1.00 33.32  ? 495  ASP   A C   1 
ATOM   1524 O  O   . ASP   A 1 232 ? -24.856 -30.406 -33.455 1.00 32.37  ? 495  ASP   A O   1 
ATOM   1525 C  CB  . ASP   A 1 232 ? -26.844 -28.527 -32.350 1.00 34.69  ? 495  ASP   A CB  1 
ATOM   1526 C  CG  . ASP   A 1 232 ? -28.199 -27.964 -31.922 1.00 32.46  ? 495  ASP   A CG  1 
ATOM   1527 O  OD1 . ASP   A 1 232 ? -29.007 -28.752 -31.519 1.00 32.08  ? 495  ASP   A OD1 1 
ATOM   1528 O  OD2 . ASP   A 1 232 ? -28.402 -26.740 -31.952 1.00 34.31  ? 495  ASP   A OD2 1 
ATOM   1529 N  N   . HIS   A 1 233 ? -24.406 -31.158 -31.391 1.00 33.61  ? 496  HIS   A N   1 
ATOM   1530 C  CA  . HIS   A 1 233 ? -23.281 -32.042 -31.805 1.00 37.17  ? 496  HIS   A CA  1 
ATOM   1531 C  C   . HIS   A 1 233 ? -22.216 -31.258 -32.591 1.00 30.11  ? 496  HIS   A C   1 
ATOM   1532 O  O   . HIS   A 1 233 ? -21.795 -31.727 -33.635 1.00 30.59  ? 496  HIS   A O   1 
ATOM   1533 C  CB  . HIS   A 1 233 ? -23.829 -33.208 -32.637 1.00 37.84  ? 496  HIS   A CB  1 
ATOM   1534 C  CG  . HIS   A 1 233 ? -24.989 -33.885 -32.010 1.00 44.79  ? 496  HIS   A CG  1 
ATOM   1535 N  ND1 . HIS   A 1 233 ? -24.915 -34.470 -30.764 1.00 51.24  ? 496  HIS   A ND1 1 
ATOM   1536 C  CD2 . HIS   A 1 233 ? -26.267 -34.034 -32.427 1.00 47.36  ? 496  HIS   A CD2 1 
ATOM   1537 C  CE1 . HIS   A 1 233 ? -26.093 -34.975 -30.447 1.00 43.46  ? 496  HIS   A CE1 1 
ATOM   1538 N  NE2 . HIS   A 1 233 ? -26.926 -34.727 -31.457 1.00 44.90  ? 496  HIS   A NE2 1 
ATOM   1539 N  N   . TRP   A 1 234 ? -21.796 -30.100 -32.109 1.00 31.77  ? 497  TRP   A N   1 
ATOM   1540 C  CA  . TRP   A 1 234 ? -20.763 -29.264 -32.782 1.00 34.74  ? 497  TRP   A CA  1 
ATOM   1541 C  C   . TRP   A 1 234 ? -19.409 -29.998 -32.820 1.00 32.81  ? 497  TRP   A C   1 
ATOM   1542 O  O   . TRP   A 1 234 ? -18.658 -29.797 -33.791 1.00 29.66  ? 497  TRP   A O   1 
ATOM   1543 C  CB  . TRP   A 1 234 ? -20.660 -27.884 -32.113 1.00 35.26  ? 497  TRP   A CB  1 
ATOM   1544 C  CG  . TRP   A 1 234 ? -21.704 -26.928 -32.611 1.00 38.49  ? 497  TRP   A CG  1 
ATOM   1545 C  CD1 . TRP   A 1 234 ? -23.058 -27.135 -32.624 1.00 36.53  ? 497  TRP   A CD1 1 
ATOM   1546 C  CD2 . TRP   A 1 234 ? -21.494 -25.630 -33.194 1.00 36.08  ? 497  TRP   A CD2 1 
ATOM   1547 N  NE1 . TRP   A 1 234 ? -23.697 -26.054 -33.162 1.00 35.72  ? 497  TRP   A NE1 1 
ATOM   1548 C  CE2 . TRP   A 1 234 ? -22.774 -25.110 -33.508 1.00 38.02  ? 497  TRP   A CE2 1 
ATOM   1549 C  CE3 . TRP   A 1 234 ? -20.373 -24.839 -33.444 1.00 36.91  ? 497  TRP   A CE3 1 
ATOM   1550 C  CZ2 . TRP   A 1 234 ? -22.955 -23.845 -34.065 1.00 36.84  ? 497  TRP   A CZ2 1 
ATOM   1551 C  CZ3 . TRP   A 1 234 ? -20.550 -23.593 -34.011 1.00 39.28  ? 497  TRP   A CZ3 1 
ATOM   1552 C  CH2 . TRP   A 1 234 ? -21.824 -23.107 -34.324 1.00 37.07  ? 497  TRP   A CH2 1 
ATOM   1553 N  N   . PHE   A 1 235 ? -19.171 -30.899 -31.863 1.00 33.44  ? 498  PHE   A N   1 
ATOM   1554 C  CA  . PHE   A 1 235 ? -17.934 -31.705 -31.728 1.00 30.57  ? 498  PHE   A CA  1 
ATOM   1555 C  C   . PHE   A 1 235 ? -18.143 -33.160 -32.166 1.00 30.14  ? 498  PHE   A C   1 
ATOM   1556 O  O   . PHE   A 1 235 ? -17.249 -34.002 -31.883 1.00 32.09  ? 498  PHE   A O   1 
ATOM   1557 C  CB  . PHE   A 1 235 ? -17.447 -31.497 -30.305 1.00 29.49  ? 498  PHE   A CB  1 
ATOM   1558 C  CG  . PHE   A 1 235 ? -17.124 -30.048 -30.103 1.00 31.60  ? 498  PHE   A CG  1 
ATOM   1559 C  CD1 . PHE   A 1 235 ? -16.083 -29.472 -30.810 1.00 32.87  ? 498  PHE   A CD1 1 
ATOM   1560 C  CD2 . PHE   A 1 235 ? -17.892 -29.252 -29.281 1.00 30.73  ? 498  PHE   A CD2 1 
ATOM   1561 C  CE1 . PHE   A 1 235 ? -15.789 -28.125 -30.666 1.00 35.88  ? 498  PHE   A CE1 1 
ATOM   1562 C  CE2 . PHE   A 1 235 ? -17.609 -27.897 -29.164 1.00 32.71  ? 498  PHE   A CE2 1 
ATOM   1563 C  CZ  . PHE   A 1 235 ? -16.565 -27.340 -29.851 1.00 32.78  ? 498  PHE   A CZ  1 
ATOM   1564 N  N   . SER   A 1 236 ? -19.188 -33.448 -32.941 1.00 27.62  ? 499  SER   A N   1 
ATOM   1565 C  CA  . SER   A 1 236 ? -19.300 -34.717 -33.700 1.00 29.56  ? 499  SER   A CA  1 
ATOM   1566 C  C   . SER   A 1 236 ? -18.064 -34.841 -34.588 1.00 28.37  ? 499  SER   A C   1 
ATOM   1567 O  O   . SER   A 1 236 ? -17.583 -33.807 -35.073 1.00 28.12  ? 499  SER   A O   1 
ATOM   1568 C  CB  . SER   A 1 236 ? -20.518 -34.755 -34.593 1.00 32.87  ? 499  SER   A CB  1 
ATOM   1569 O  OG  . SER   A 1 236 ? -20.403 -33.761 -35.634 1.00 35.01  ? 499  SER   A OG  1 
ATOM   1570 N  N   . ARG   A 1 237 ? -17.664 -36.061 -34.942 1.00 30.45  ? 500  ARG   A N   1 
ATOM   1571 C  CA  . ARG   A 1 237 ? -16.553 -36.248 -35.892 1.00 31.39  ? 500  ARG   A CA  1 
ATOM   1572 C  C   . ARG   A 1 237 ? -16.915 -35.635 -37.253 1.00 33.31  ? 500  ARG   A C   1 
ATOM   1573 O  O   . ARG   A 1 237 ? -16.057 -34.945 -37.866 1.00 33.08  ? 500  ARG   A O   1 
ATOM   1574 C  CB  . ARG   A 1 237 ? -16.145 -37.712 -36.032 1.00 32.88  ? 500  ARG   A CB  1 
ATOM   1575 C  CG  . ARG   A 1 237 ? -14.736 -37.840 -36.605 1.00 30.95  ? 500  ARG   A CG  1 
ATOM   1576 C  CD  . ARG   A 1 237 ? -14.062 -39.107 -36.173 1.00 31.22  ? 500  ARG   A CD  1 
ATOM   1577 N  NE  . ARG   A 1 237 ? -12.697 -39.024 -36.636 1.00 28.83  ? 500  ARG   A NE  1 
ATOM   1578 C  CZ  . ARG   A 1 237 ? -11.700 -38.413 -36.007 1.00 28.19  ? 500  ARG   A CZ  1 
ATOM   1579 N  NH1 . ARG   A 1 237 ? -11.893 -37.819 -34.844 1.00 27.31  ? 500  ARG   A NH1 1 
ATOM   1580 N  NH2 . ARG   A 1 237 ? -10.488 -38.413 -36.561 1.00 27.12  ? 500  ARG   A NH2 1 
ATOM   1581 N  N   . GLU   A 1 238 ? -18.136 -35.856 -37.717 1.00 33.26  ? 501  GLU   A N   1 
ATOM   1582 C  CA  . GLU   A 1 238 ? -18.599 -35.405 -39.060 1.00 35.20  ? 501  GLU   A CA  1 
ATOM   1583 C  C   . GLU   A 1 238 ? -18.475 -33.881 -39.138 1.00 29.55  ? 501  GLU   A C   1 
ATOM   1584 O  O   . GLU   A 1 238 ? -17.959 -33.372 -40.116 1.00 32.56  ? 501  GLU   A O   1 
ATOM   1585 C  CB  . GLU   A 1 238 ? -20.042 -35.880 -39.266 1.00 44.55  ? 501  GLU   A CB  1 
ATOM   1586 C  CG  . GLU   A 1 238 ? -20.498 -35.768 -40.688 1.00 54.57  ? 501  GLU   A CG  1 
ATOM   1587 C  CD  . GLU   A 1 238 ? -21.877 -35.158 -40.795 1.00 71.54  ? 501  GLU   A CD  1 
ATOM   1588 O  OE1 . GLU   A 1 238 ? -21.973 -33.899 -40.658 1.00 80.51  ? 501  GLU   A OE1 1 
ATOM   1589 O  OE2 . GLU   A 1 238 ? -22.849 -35.947 -40.964 1.00 64.75  ? 501  GLU   A OE2 1 
ATOM   1590 N  N   . ASN   A 1 239 ? -18.844 -33.172 -38.090 1.00 26.90  ? 502  ASN   A N   1 
ATOM   1591 C  CA  . ASN   A 1 239 ? -18.813 -31.695 -38.103 1.00 32.06  ? 502  ASN   A CA  1 
ATOM   1592 C  C   . ASN   A 1 239 ? -17.442 -31.056 -37.783 1.00 31.01  ? 502  ASN   A C   1 
ATOM   1593 O  O   . ASN   A 1 239 ? -17.154 -30.022 -38.333 1.00 31.76  ? 502  ASN   A O   1 
ATOM   1594 C  CB  . ASN   A 1 239 ? -19.787 -31.113 -37.085 1.00 30.20  ? 502  ASN   A CB  1 
ATOM   1595 C  CG  . ASN   A 1 239 ? -19.946 -29.636 -37.348 1.00 32.96  ? 502  ASN   A CG  1 
ATOM   1596 O  OD1 . ASN   A 1 239 ? -20.296 -29.269 -38.462 1.00 35.57  ? 502  ASN   A OD1 1 
ATOM   1597 N  ND2 . ASN   A 1 239 ? -19.655 -28.792 -36.363 1.00 34.52  ? 502  ASN   A ND2 1 
ATOM   1598 N  N   . SER   A 1 240 ? -16.712 -31.615 -36.816 0.50 34.27  ? 503  SER   A N   1 
ATOM   1599 C  CA  . SER   A 1 240 ? -15.315 -31.246 -36.459 0.50 37.07  ? 503  SER   A CA  1 
ATOM   1600 C  C   . SER   A 1 240 ? -14.450 -32.494 -36.623 0.50 39.27  ? 503  SER   A C   1 
ATOM   1601 O  O   . SER   A 1 240 ? -14.536 -33.390 -35.754 0.50 48.05  ? 503  SER   A O   1 
ATOM   1602 C  CB  . SER   A 1 240 ? -15.223 -30.706 -35.058 0.50 36.65  ? 503  SER   A CB  1 
ATOM   1603 O  OG  . SER   A 1 240 ? -15.022 -31.755 -34.120 0.50 37.37  ? 503  SER   A OG  1 
ATOM   1604 N  N   . LEU   A 1 241 ? -13.679 -32.569 -37.705 0.50 37.94  ? 504  LEU   A N   1 
ATOM   1605 C  CA  . LEU   A 1 241 ? -12.995 -33.812 -38.150 0.50 36.29  ? 504  LEU   A CA  1 
ATOM   1606 C  C   . LEU   A 1 241 ? -12.059 -34.355 -37.050 0.50 34.73  ? 504  LEU   A C   1 
ATOM   1607 O  O   . LEU   A 1 241 ? -11.528 -35.476 -37.238 0.50 33.76  ? 504  LEU   A O   1 
ATOM   1608 C  CB  . LEU   A 1 241 ? -12.240 -33.501 -39.447 0.50 37.67  ? 504  LEU   A CB  1 
ATOM   1609 C  CG  . LEU   A 1 241 ? -13.065 -32.869 -40.570 0.50 36.76  ? 504  LEU   A CG  1 
ATOM   1610 C  CD1 . LEU   A 1 241 ? -12.195 -32.552 -41.773 0.50 36.03  ? 504  LEU   A CD1 1 
ATOM   1611 C  CD2 . LEU   A 1 241 ? -14.212 -33.772 -40.987 0.50 40.30  ? 504  LEU   A CD2 1 
ATOM   1612 N  N   . SER   A 1 242 ? -11.850 -33.622 -35.945 1.00 30.32  ? 505  SER   A N   1 
ATOM   1613 C  CA  . SER   A 1 242 ? -11.022 -34.120 -34.811 1.00 29.43  ? 505  SER   A CA  1 
ATOM   1614 C  C   . SER   A 1 242 ? -11.869 -34.726 -33.709 1.00 27.64  ? 505  SER   A C   1 
ATOM   1615 O  O   . SER   A 1 242 ? -11.344 -35.541 -32.938 1.00 22.64  ? 505  SER   A O   1 
ATOM   1616 C  CB  . SER   A 1 242 ? -10.149 -33.027 -34.196 1.00 27.82  ? 505  SER   A CB  1 
ATOM   1617 O  OG  . SER   A 1 242 ? -9.394  -32.402 -35.186 1.00 29.48  ? 505  SER   A OG  1 
ATOM   1618 N  N   . GLY   A 1 243 ? -13.079 -34.215 -33.524 1.00 27.71  ? 506  GLY   A N   1 
ATOM   1619 C  CA  . GLY   A 1 243 ? -13.934 -34.578 -32.377 1.00 25.98  ? 506  GLY   A CA  1 
ATOM   1620 C  C   . GLY   A 1 243 ? -14.481 -35.984 -32.502 1.00 25.81  ? 506  GLY   A C   1 
ATOM   1621 O  O   . GLY   A 1 243 ? -14.368 -36.585 -33.560 1.00 27.30  ? 506  GLY   A O   1 
ATOM   1622 N  N   . VAL   A 1 244 ? -15.037 -36.463 -31.410 1.00 26.22  ? 507  VAL   A N   1 
ATOM   1623 C  CA  . VAL   A 1 244 ? -15.660 -37.801 -31.254 1.00 30.79  ? 507  VAL   A CA  1 
ATOM   1624 C  C   . VAL   A 1 244 ? -16.957 -37.679 -30.397 1.00 30.05  ? 507  VAL   A C   1 
ATOM   1625 O  O   . VAL   A 1 244 ? -17.374 -38.694 -29.817 1.00 28.39  ? 507  VAL   A O   1 
ATOM   1626 C  CB  . VAL   A 1 244 ? -14.667 -38.773 -30.582 1.00 30.63  ? 507  VAL   A CB  1 
ATOM   1627 C  CG1 . VAL   A 1 244 ? -13.408 -39.043 -31.401 1.00 32.54  ? 507  VAL   A CG1 1 
ATOM   1628 C  CG2 . VAL   A 1 244 ? -14.290 -38.272 -29.206 1.00 31.50  ? 507  VAL   A CG2 1 
ATOM   1629 N  N   . GLU   A 1 245 ? -17.524 -36.487 -30.204 1.00 28.00  ? 508  GLU   A N   1 
ATOM   1630 C  CA  . GLU   A 1 245 ? -18.742 -36.345 -29.342 1.00 33.76  ? 508  GLU   A CA  1 
ATOM   1631 C  C   . GLU   A 1 245 ? -19.860 -37.248 -29.891 1.00 28.83  ? 508  GLU   A C   1 
ATOM   1632 O  O   . GLU   A 1 245 ? -20.100 -37.247 -31.114 1.00 28.19  ? 508  GLU   A O   1 
ATOM   1633 C  CB  . GLU   A 1 245 ? -19.268 -34.917 -29.250 1.00 33.32  ? 508  GLU   A CB  1 
ATOM   1634 C  CG  . GLU   A 1 245 ? -20.369 -34.753 -28.195 1.00 40.60  ? 508  GLU   A CG  1 
ATOM   1635 C  CD  . GLU   A 1 245 ? -21.784 -35.153 -28.614 1.00 46.31  ? 508  GLU   A CD  1 
ATOM   1636 O  OE1 . GLU   A 1 245 ? -22.136 -34.936 -29.809 1.00 49.23  ? 508  GLU   A OE1 1 
ATOM   1637 O  OE2 . GLU   A 1 245 ? -22.543 -35.704 -27.744 1.00 57.49  ? 508  GLU   A OE2 1 
ATOM   1638 N  N   . GLY   A 1 246 ? -20.479 -38.050 -29.032 1.00 33.92  ? 509  GLY   A N   1 
ATOM   1639 C  CA  . GLY   A 1 246 ? -21.565 -38.956 -29.457 1.00 36.44  ? 509  GLY   A CA  1 
ATOM   1640 C  C   . GLY   A 1 246 ? -21.036 -40.229 -30.105 1.00 37.00  ? 509  GLY   A C   1 
ATOM   1641 O  O   . GLY   A 1 246 ? -21.890 -41.066 -30.471 1.00 35.94  ? 509  GLY   A O   1 
ATOM   1642 N  N   . GLU   A 1 247 ? -19.713 -40.426 -30.243 1.00 35.06  ? 510  GLU   A N   1 
ATOM   1643 C  CA  . GLU   A 1 247 ? -19.239 -41.572 -31.067 1.00 38.73  ? 510  GLU   A CA  1 
ATOM   1644 C  C   . GLU   A 1 247 ? -19.535 -42.857 -30.290 1.00 37.10  ? 510  GLU   A C   1 
ATOM   1645 O  O   . GLU   A 1 247 ? -20.275 -43.684 -30.831 1.00 50.42  ? 510  GLU   A O   1 
ATOM   1646 C  CB  . GLU   A 1 247 ? -17.785 -41.498 -31.550 1.00 38.45  ? 510  GLU   A CB  1 
ATOM   1647 C  CG  . GLU   A 1 247 ? -17.546 -40.382 -32.548 1.00 42.62  ? 510  GLU   A CG  1 
ATOM   1648 C  CD  . GLU   A 1 247 ? -18.489 -40.301 -33.740 1.00 46.04  ? 510  GLU   A CD  1 
ATOM   1649 O  OE1 . GLU   A 1 247 ? -18.725 -41.376 -34.282 1.00 42.63  ? 510  GLU   A OE1 1 
ATOM   1650 O  OE2 . GLU   A 1 247 ? -18.976 -39.125 -34.129 1.00 47.62  ? 510  GLU   A OE2 1 
ATOM   1651 N  N   . GLY   A 1 248 ? -19.064 -43.052 -29.071 1.00 35.32  ? 511  GLY   A N   1 
ATOM   1652 C  CA  . GLY   A 1 248 ? -19.316 -44.376 -28.436 1.00 35.92  ? 511  GLY   A CA  1 
ATOM   1653 C  C   . GLY   A 1 248 ? -18.059 -45.246 -28.475 1.00 36.48  ? 511  GLY   A C   1 
ATOM   1654 O  O   . GLY   A 1 248 ? -17.289 -45.185 -29.453 1.00 36.93  ? 511  GLY   A O   1 
ATOM   1655 N  N   A LEU   A 1 249 ? -17.872 -46.044 -27.426 0.24 35.44  ? 512  LEU   A N   1 
ATOM   1656 N  N   B LEU   A 1 249 ? -17.830 -46.022 -27.411 0.25 35.75  ? 512  LEU   A N   1 
ATOM   1657 C  CA  A LEU   A 1 249 ? -16.640 -46.817 -27.136 0.24 35.18  ? 512  LEU   A CA  1 
ATOM   1658 C  CA  B LEU   A 1 249 ? -16.587 -46.806 -27.175 0.25 35.66  ? 512  LEU   A CA  1 
ATOM   1659 C  C   A LEU   A 1 249 ? -16.373 -47.819 -28.260 0.24 33.95  ? 512  LEU   A C   1 
ATOM   1660 C  C   B LEU   A 1 249 ? -16.351 -47.780 -28.329 0.25 34.21  ? 512  LEU   A C   1 
ATOM   1661 O  O   A LEU   A 1 249 ? -15.199 -48.140 -28.499 0.24 32.74  ? 512  LEU   A O   1 
ATOM   1662 O  O   B LEU   A 1 249 ? -15.182 -48.063 -28.631 0.25 32.70  ? 512  LEU   A O   1 
ATOM   1663 C  CB  A LEU   A 1 249 ? -16.860 -47.528 -25.801 0.24 35.48  ? 512  LEU   A CB  1 
ATOM   1664 C  CB  B LEU   A 1 249 ? -16.725 -47.580 -25.862 0.25 36.43  ? 512  LEU   A CB  1 
ATOM   1665 C  CG  A LEU   A 1 249 ? -15.598 -47.897 -25.037 0.24 33.66  ? 512  LEU   A CG  1 
ATOM   1666 C  CG  B LEU   A 1 249 ? -16.043 -46.953 -24.653 0.25 35.04  ? 512  LEU   A CG  1 
ATOM   1667 C  CD1 A LEU   A 1 249 ? -14.546 -46.804 -25.173 0.24 32.83  ? 512  LEU   A CD1 1 
ATOM   1668 C  CD1 B LEU   A 1 249 ? -16.222 -47.840 -23.433 0.25 34.82  ? 512  LEU   A CD1 1 
ATOM   1669 C  CD2 A LEU   A 1 249 ? -15.934 -48.160 -23.583 0.24 33.53  ? 512  LEU   A CD2 1 
ATOM   1670 C  CD2 B LEU   A 1 249 ? -14.568 -46.709 -24.939 0.25 34.37  ? 512  LEU   A CD2 1 
ATOM   1671 N  N   . HIS   A 1 250 ? -17.436 -48.289 -28.915 0.48 32.32  ? 513  HIS   A N   1 
ATOM   1672 C  CA  . HIS   A 1 250 ? -17.404 -49.274 -30.028 0.48 31.96  ? 513  HIS   A CA  1 
ATOM   1673 C  C   . HIS   A 1 250 ? -16.927 -48.610 -31.321 0.48 31.28  ? 513  HIS   A C   1 
ATOM   1674 O  O   . HIS   A 1 250 ? -16.643 -49.343 -32.285 0.48 30.60  ? 513  HIS   A O   1 
ATOM   1675 C  CB  . HIS   A 1 250 ? -18.799 -49.872 -30.233 0.48 32.07  ? 513  HIS   A CB  1 
ATOM   1676 C  CG  . HIS   A 1 250 ? -19.847 -48.837 -30.453 0.48 30.71  ? 513  HIS   A CG  1 
ATOM   1677 N  ND1 . HIS   A 1 250 ? -20.138 -47.877 -29.506 0.48 30.25  ? 513  HIS   A ND1 1 
ATOM   1678 C  CD2 . HIS   A 1 250 ? -20.660 -48.599 -31.504 0.48 31.04  ? 513  HIS   A CD2 1 
ATOM   1679 C  CE1 . HIS   A 1 250 ? -21.095 -47.092 -29.962 0.48 30.53  ? 513  HIS   A CE1 1 
ATOM   1680 N  NE2 . HIS   A 1 250 ? -21.435 -47.519 -31.182 0.48 31.54  ? 513  HIS   A NE2 1 
ATOM   1681 N  N   . LYS   A 1 251 ? -16.872 -47.274 -31.346 0.48 31.81  ? 514  LYS   A N   1 
ATOM   1682 C  CA  . LYS   A 1 251 ? -16.436 -46.484 -32.530 0.48 32.09  ? 514  LYS   A CA  1 
ATOM   1683 C  C   . LYS   A 1 251 ? -14.989 -45.997 -32.361 0.48 30.75  ? 514  LYS   A C   1 
ATOM   1684 O  O   . LYS   A 1 251 ? -14.268 -45.959 -33.378 0.48 29.41  ? 514  LYS   A O   1 
ATOM   1685 C  CB  . LYS   A 1 251 ? -17.391 -45.309 -32.737 0.48 35.34  ? 514  LYS   A CB  1 
ATOM   1686 C  CG  . LYS   A 1 251 ? -18.860 -45.657 -32.531 0.48 37.76  ? 514  LYS   A CG  1 
ATOM   1687 C  CD  . LYS   A 1 251 ? -19.545 -46.178 -33.763 0.48 38.51  ? 514  LYS   A CD  1 
ATOM   1688 C  CE  . LYS   A 1 251 ? -20.366 -45.106 -34.443 0.48 38.91  ? 514  LYS   A CE  1 
ATOM   1689 N  NZ  . LYS   A 1 251 ? -21.214 -45.682 -35.508 0.48 40.10  ? 514  LYS   A NZ  1 
ATOM   1690 N  N   . LEU   A 1 252 ? -14.585 -45.630 -31.140 1.00 29.27  ? 515  LEU   A N   1 
ATOM   1691 C  CA  . LEU   A 1 252 ? -13.264 -44.965 -30.886 1.00 30.66  ? 515  LEU   A CA  1 
ATOM   1692 C  C   . LEU   A 1 252 ? -12.116 -45.766 -31.493 1.00 27.83  ? 515  LEU   A C   1 
ATOM   1693 O  O   . LEU   A 1 252 ? -11.271 -45.166 -32.137 1.00 30.97  ? 515  LEU   A O   1 
ATOM   1694 C  CB  . LEU   A 1 252 ? -13.073 -44.754 -29.393 1.00 28.35  ? 515  LEU   A CB  1 
ATOM   1695 C  CG  . LEU   A 1 252 ? -14.144 -43.891 -28.739 1.00 30.09  ? 515  LEU   A CG  1 
ATOM   1696 C  CD1 . LEU   A 1 252 ? -13.750 -43.549 -27.319 1.00 34.67  ? 515  LEU   A CD1 1 
ATOM   1697 C  CD2 . LEU   A 1 252 ? -14.394 -42.615 -29.516 1.00 29.35  ? 515  LEU   A CD2 1 
ATOM   1698 N  N   . GLY   A 1 253 ? -12.141 -47.095 -31.379 1.00 28.17  ? 516  GLY   A N   1 
ATOM   1699 C  CA  . GLY   A 1 253 ? -11.061 -47.938 -31.920 1.00 26.56  ? 516  GLY   A CA  1 
ATOM   1700 C  C   . GLY   A 1 253 ? -10.985 -47.846 -33.433 1.00 26.61  ? 516  GLY   A C   1 
ATOM   1701 O  O   . GLY   A 1 253 ? -9.879  -47.742 -33.990 1.00 28.30  ? 516  GLY   A O   1 
ATOM   1702 N  N   . TYR   A 1 254 ? -12.124 -47.874 -34.106 1.00 23.82  ? 517  TYR   A N   1 
ATOM   1703 C  CA  . TYR   A 1 254 ? -12.182 -47.737 -35.581 1.00 26.11  ? 517  TYR   A CA  1 
ATOM   1704 C  C   . TYR   A 1 254 ? -11.661 -46.355 -35.998 1.00 25.16  ? 517  TYR   A C   1 
ATOM   1705 O  O   . TYR   A 1 254 ? -10.914 -46.233 -36.978 1.00 27.76  ? 517  TYR   A O   1 
ATOM   1706 C  CB  . TYR   A 1 254 ? -13.600 -47.968 -36.093 1.00 27.32  ? 517  TYR   A CB  1 
ATOM   1707 C  CG  . TYR   A 1 254 ? -14.059 -49.403 -36.097 1.00 27.31  ? 517  TYR   A CG  1 
ATOM   1708 C  CD1 . TYR   A 1 254 ? -13.541 -50.321 -37.007 1.00 29.55  ? 517  TYR   A CD1 1 
ATOM   1709 C  CD2 . TYR   A 1 254 ? -15.032 -49.844 -35.219 1.00 28.41  ? 517  TYR   A CD2 1 
ATOM   1710 C  CE1 . TYR   A 1 254 ? -13.955 -51.645 -37.039 1.00 26.60  ? 517  TYR   A CE1 1 
ATOM   1711 C  CE2 . TYR   A 1 254 ? -15.480 -51.155 -35.258 1.00 27.26  ? 517  TYR   A CE2 1 
ATOM   1712 C  CZ  . TYR   A 1 254 ? -14.971 -52.049 -36.187 1.00 30.37  ? 517  TYR   A CZ  1 
ATOM   1713 O  OH  . TYR   A 1 254 ? -15.458 -53.343 -36.229 1.00 29.09  ? 517  TYR   A OH  1 
ATOM   1714 N  N   . ILE   A 1 255 ? -11.984 -45.345 -35.222 1.00 23.46  ? 518  ILE   A N   1 
ATOM   1715 C  CA  . ILE   A 1 255 ? -11.534 -43.971 -35.505 1.00 27.21  ? 518  ILE   A CA  1 
ATOM   1716 C  C   . ILE   A 1 255 ? -10.008 -43.907 -35.412 1.00 28.96  ? 518  ILE   A C   1 
ATOM   1717 O  O   . ILE   A 1 255 ? -9.421  -43.388 -36.382 1.00 31.94  ? 518  ILE   A O   1 
ATOM   1718 C  CB  . ILE   A 1 255 ? -12.274 -42.971 -34.599 1.00 27.42  ? 518  ILE   A CB  1 
ATOM   1719 C  CG1 . ILE   A 1 255 ? -13.745 -42.881 -35.046 1.00 29.98  ? 518  ILE   A CG1 1 
ATOM   1720 C  CG2 . ILE   A 1 255 ? -11.572 -41.612 -34.597 1.00 29.57  ? 518  ILE   A CG2 1 
ATOM   1721 C  CD1 . ILE   A 1 255 ? -14.674 -42.188 -34.047 1.00 29.52  ? 518  ILE   A CD1 1 
ATOM   1722 N  N   . LEU   A 1 256 ? -9.399  -44.452 -34.351 1.00 30.20  ? 519  LEU   A N   1 
ATOM   1723 C  CA  . LEU   A 1 256 ? -7.927  -44.436 -34.150 1.00 34.07  ? 519  LEU   A CA  1 
ATOM   1724 C  C   . LEU   A 1 256 ? -7.250  -45.192 -35.286 1.00 32.53  ? 519  LEU   A C   1 
ATOM   1725 O  O   . LEU   A 1 256 ? -6.156  -44.748 -35.704 1.00 34.74  ? 519  LEU   A O   1 
ATOM   1726 C  CB  . LEU   A 1 256 ? -7.533  -45.100 -32.825 1.00 34.81  ? 519  LEU   A CB  1 
ATOM   1727 C  CG  . LEU   A 1 256 ? -7.872  -44.348 -31.538 1.00 34.81  ? 519  LEU   A CG  1 
ATOM   1728 C  CD1 . LEU   A 1 256 ? -7.165  -45.027 -30.383 1.00 34.71  ? 519  LEU   A CD1 1 
ATOM   1729 C  CD2 . LEU   A 1 256 ? -7.495  -42.868 -31.597 1.00 35.18  ? 519  LEU   A CD2 1 
ATOM   1730 N  N   . ARG   A 1 257 ? -7.823  -46.331 -35.707 1.00 34.13  ? 520  ARG   A N   1 
ATOM   1731 C  CA  . ARG   A 1 257 ? -7.297  -47.122 -36.855 1.00 33.35  ? 520  ARG   A CA  1 
ATOM   1732 C  C   . ARG   A 1 257 ? -7.413  -46.298 -38.146 1.00 34.45  ? 520  ARG   A C   1 
ATOM   1733 O  O   . ARG   A 1 257 ? -6.436  -46.375 -38.968 1.00 29.37  ? 520  ARG   A O   1 
ATOM   1734 C  CB  . ARG   A 1 257 ? -7.995  -48.468 -37.008 1.00 31.38  ? 520  ARG   A CB  1 
ATOM   1735 C  CG  . ARG   A 1 257 ? -7.417  -49.324 -38.133 1.00 30.48  ? 520  ARG   A CG  1 
ATOM   1736 C  CD  . ARG   A 1 257 ? -8.154  -50.647 -38.264 1.00 30.10  ? 520  ARG   A CD  1 
ATOM   1737 N  NE  . ARG   A 1 257 ? -9.448  -50.464 -38.926 1.00 34.01  ? 520  ARG   A NE  1 
ATOM   1738 C  CZ  . ARG   A 1 257 ? -10.285 -51.435 -39.294 1.00 30.87  ? 520  ARG   A CZ  1 
ATOM   1739 N  NH1 . ARG   A 1 257 ? -10.025 -52.698 -39.050 1.00 28.99  ? 520  ARG   A NH1 1 
ATOM   1740 N  NH2 . ARG   A 1 257 ? -11.404 -51.118 -39.898 1.00 37.43  ? 520  ARG   A NH2 1 
ATOM   1741 N  N   . ASP   A 1 258 ? -8.494  -45.516 -38.312 1.00 30.61  ? 521  ASP   A N   1 
ATOM   1742 C  CA  . ASP   A 1 258 ? -8.619  -44.608 -39.501 1.00 35.20  ? 521  ASP   A CA  1 
ATOM   1743 C  C   . ASP   A 1 258 ? -7.487  -43.553 -39.444 1.00 31.17  ? 521  ASP   A C   1 
ATOM   1744 O  O   . ASP   A 1 258 ? -6.804  -43.380 -40.406 1.00 32.34  ? 521  ASP   A O   1 
ATOM   1745 C  CB  . ASP   A 1 258 ? -10.017 -44.005 -39.708 1.00 34.25  ? 521  ASP   A CB  1 
ATOM   1746 C  CG  . ASP   A 1 258 ? -11.058 -44.908 -40.405 1.00 37.43  ? 521  ASP   A CG  1 
ATOM   1747 O  OD1 . ASP   A 1 258 ? -10.697 -45.978 -40.909 1.00 34.80  ? 521  ASP   A OD1 1 
ATOM   1748 O  OD2 . ASP   A 1 258 ? -12.274 -44.547 -40.391 1.00 41.70  ? 521  ASP   A OD2 1 
ATOM   1749 N  N   . VAL   A 1 259 ? -7.246  -42.905 -38.327 1.00 29.61  ? 522  VAL   A N   1 
ATOM   1750 C  CA  . VAL   A 1 259 ? -6.101  -41.986 -38.199 1.00 33.16  ? 522  VAL   A CA  1 
ATOM   1751 C  C   . VAL   A 1 259 ? -4.798  -42.740 -38.545 1.00 33.63  ? 522  VAL   A C   1 
ATOM   1752 O  O   . VAL   A 1 259 ? -4.012  -42.176 -39.246 1.00 32.62  ? 522  VAL   A O   1 
ATOM   1753 C  CB  . VAL   A 1 259 ? -6.037  -41.414 -36.787 1.00 33.87  ? 522  VAL   A CB  1 
ATOM   1754 C  CG1 . VAL   A 1 259 ? -4.745  -40.614 -36.627 1.00 37.34  ? 522  VAL   A CG1 1 
ATOM   1755 C  CG2 . VAL   A 1 259 ? -7.282  -40.594 -36.498 1.00 33.49  ? 522  VAL   A CG2 1 
ATOM   1756 N  N   . SER   A 1 260 ? -4.605  -43.983 -38.096 1.00 31.44  ? 523  SER   A N   1 
ATOM   1757 C  CA  . SER   A 1 260 ? -3.360  -44.769 -38.313 1.00 33.05  ? 523  SER   A CA  1 
ATOM   1758 C  C   . SER   A 1 260 ? -3.073  -44.922 -39.812 1.00 34.03  ? 523  SER   A C   1 
ATOM   1759 O  O   . SER   A 1 260 ? -1.924  -44.999 -40.148 1.00 34.13  ? 523  SER   A O   1 
ATOM   1760 C  CB  . SER   A 1 260 ? -3.409  -46.113 -37.646 1.00 31.73  ? 523  SER   A CB  1 
ATOM   1761 O  OG  . SER   A 1 260 ? -3.944  -47.082 -38.526 1.00 34.78  ? 523  SER   A OG  1 
ATOM   1762 N  N   . LYS   A 1 261 ? -4.089  -44.867 -40.664 1.00 36.10  ? 524  LYS   A N   1 
ATOM   1763 C  CA  . LYS   A 1 261 ? -4.023  -45.139 -42.127 1.00 38.98  ? 524  LYS   A CA  1 
ATOM   1764 C  C   . LYS   A 1 261 ? -3.400  -43.967 -42.890 1.00 39.21  ? 524  LYS   A C   1 
ATOM   1765 O  O   . LYS   A 1 261 ? -3.014  -44.192 -44.052 1.00 42.60  ? 524  LYS   A O   1 
ATOM   1766 C  CB  . LYS   A 1 261 ? -5.430  -45.354 -42.697 1.00 38.99  ? 524  LYS   A CB  1 
ATOM   1767 C  CG  . LYS   A 1 261 ? -5.942  -46.765 -42.506 1.00 49.74  ? 524  LYS   A CG  1 
ATOM   1768 C  CD  . LYS   A 1 261 ? -7.336  -46.912 -43.026 1.00 55.22  ? 524  LYS   A CD  1 
ATOM   1769 C  CE  . LYS   A 1 261 ? -7.969  -48.199 -42.586 1.00 62.06  ? 524  LYS   A CE  1 
ATOM   1770 N  NZ  . LYS   A 1 261 ? -9.438  -48.007 -42.532 1.00 82.78  ? 524  LYS   A NZ  1 
ATOM   1771 N  N   . LYS   A 1 262 ? -3.426  -42.769 -42.303 1.00 36.72  ? 525  LYS   A N   1 
ATOM   1772 C  CA  . LYS   A 1 262 ? -2.778  -41.553 -42.840 1.00 41.12  ? 525  LYS   A CA  1 
ATOM   1773 C  C   . LYS   A 1 262 ? -1.269  -41.769 -42.872 1.00 41.04  ? 525  LYS   A C   1 
ATOM   1774 O  O   . LYS   A 1 262 ? -0.731  -42.468 -42.004 1.00 50.14  ? 525  LYS   A O   1 
ATOM   1775 C  CB  . LYS   A 1 262 ? -3.153  -40.323 -42.013 1.00 40.64  ? 525  LYS   A CB  1 
ATOM   1776 C  CG  . LYS   A 1 262 ? -4.659  -40.079 -41.995 1.00 41.47  ? 525  LYS   A CG  1 
ATOM   1777 C  CD  . LYS   A 1 262 ? -5.041  -38.655 -41.971 1.00 43.87  ? 525  LYS   A CD  1 
ATOM   1778 C  CE  . LYS   A 1 262 ? -6.463  -38.425 -42.410 1.00 50.94  ? 525  LYS   A CE  1 
ATOM   1779 N  NZ  . LYS   A 1 262 ? -6.533  -37.260 -43.322 1.00 57.46  ? 525  LYS   A NZ  1 
ATOM   1780 N  N   . GLU   A 1 263 ? -0.633  -41.232 -43.897 1.00 44.93  ? 526  GLU   A N   1 
ATOM   1781 C  CA  . GLU   A 1 263 ? 0.841   -41.156 -43.977 1.00 46.64  ? 526  GLU   A CA  1 
ATOM   1782 C  C   . GLU   A 1 263 ? 1.256   -40.163 -42.896 1.00 39.59  ? 526  GLU   A C   1 
ATOM   1783 O  O   . GLU   A 1 263 ? 0.564   -39.149 -42.771 1.00 42.66  ? 526  GLU   A O   1 
ATOM   1784 C  CB  . GLU   A 1 263 ? 1.256   -40.737 -45.389 1.00 55.74  ? 526  GLU   A CB  1 
ATOM   1785 C  CG  . GLU   A 1 263 ? 0.959   -41.790 -46.454 1.00 65.67  ? 526  GLU   A CG  1 
ATOM   1786 C  CD  . GLU   A 1 263 ? 1.919   -42.972 -46.482 1.00 76.62  ? 526  GLU   A CD  1 
ATOM   1787 O  OE1 . GLU   A 1 263 ? 3.140   -42.745 -46.329 1.00 87.96  ? 526  GLU   A OE1 1 
ATOM   1788 O  OE2 . GLU   A 1 263 ? 1.449   -44.114 -46.660 1.00 78.45  ? 526  GLU   A OE2 1 
ATOM   1789 N  N   . GLY   A 1 264 ? 2.286   -40.469 -42.118 1.00 36.04  ? 527  GLY   A N   1 
ATOM   1790 C  CA  . GLY   A 1 264 ? 2.847   -39.516 -41.148 1.00 38.53  ? 527  GLY   A CA  1 
ATOM   1791 C  C   . GLY   A 1 264 ? 3.756   -40.187 -40.138 1.00 39.50  ? 527  GLY   A C   1 
ATOM   1792 O  O   . GLY   A 1 264 ? 4.230   -41.308 -40.374 1.00 39.74  ? 527  GLY   A O   1 
ATOM   1793 N  N   . GLY   A 1 265 ? 3.983   -39.539 -39.008 1.00 40.38  ? 528  GLY   A N   1 
ATOM   1794 C  CA  . GLY   A 1 265 ? 4.940   -40.065 -38.024 1.00 42.88  ? 528  GLY   A CA  1 
ATOM   1795 C  C   . GLY   A 1 265 ? 4.248   -40.970 -37.028 1.00 43.23  ? 528  GLY   A C   1 
ATOM   1796 O  O   . GLY   A 1 265 ? 3.203   -41.569 -37.368 1.00 40.49  ? 528  GLY   A O   1 
ATOM   1797 N  N   . ALA   A 1 266 ? 4.798   -41.046 -35.825 1.00 38.09  ? 529  ALA   A N   1 
ATOM   1798 C  CA  . ALA   A 1 266 ? 4.256   -41.852 -34.720 1.00 35.19  ? 529  ALA   A CA  1 
ATOM   1799 C  C   . ALA   A 1 266 ? 2.873   -41.305 -34.364 1.00 32.06  ? 529  ALA   A C   1 
ATOM   1800 O  O   . ALA   A 1 266 ? 2.483   -40.227 -34.865 1.00 35.21  ? 529  ALA   A O   1 
ATOM   1801 C  CB  . ALA   A 1 266 ? 5.211   -41.805 -33.549 1.00 30.53  ? 529  ALA   A CB  1 
ATOM   1802 N  N   . MET   A 1 267 ? 2.174   -41.969 -33.458 1.00 33.07  ? 530  MET   A N   1 
ATOM   1803 C  CA  . MET   A 1 267 ? 0.933   -41.408 -32.870 1.00 31.79  ? 530  MET   A CA  1 
ATOM   1804 C  C   . MET   A 1 267 ? 1.308   -40.857 -31.484 1.00 29.55  ? 530  MET   A C   1 
ATOM   1805 O  O   . MET   A 1 267 ? 2.020   -41.548 -30.718 1.00 33.47  ? 530  MET   A O   1 
ATOM   1806 C  CB  . MET   A 1 267 ? -0.194  -42.456 -32.836 1.00 33.70  ? 530  MET   A CB  1 
ATOM   1807 C  CG  . MET   A 1 267 ? -0.711  -42.813 -34.211 1.00 37.85  ? 530  MET   A CG  1 
ATOM   1808 S  SD  . MET   A 1 267 ? -2.077  -44.045 -34.289 1.00 41.38  ? 530  MET   A SD  1 
ATOM   1809 C  CE  . MET   A 1 267 ? -3.531  -43.089 -33.906 1.00 44.70  ? 530  MET   A CE  1 
ATOM   1810 N  N   . TYR   A 1 268 ? 0.927   -39.618 -31.202 1.00 28.19  ? 531  TYR   A N   1 
ATOM   1811 C  CA  . TYR   A 1 268 ? 1.281   -38.911 -29.953 1.00 27.46  ? 531  TYR   A CA  1 
ATOM   1812 C  C   . TYR   A 1 268 ? 0.016   -38.769 -29.149 1.00 28.29  ? 531  TYR   A C   1 
ATOM   1813 O  O   . TYR   A 1 268 ? -1.035  -38.500 -29.741 1.00 31.71  ? 531  TYR   A O   1 
ATOM   1814 C  CB  . TYR   A 1 268 ? 1.950   -37.576 -30.256 1.00 30.50  ? 531  TYR   A CB  1 
ATOM   1815 C  CG  . TYR   A 1 268 ? 3.270   -37.744 -30.965 1.00 32.42  ? 531  TYR   A CG  1 
ATOM   1816 C  CD1 . TYR   A 1 268 ? 3.326   -37.892 -32.334 1.00 30.64  ? 531  TYR   A CD1 1 
ATOM   1817 C  CD2 . TYR   A 1 268 ? 4.450   -37.871 -30.256 1.00 32.94  ? 531  TYR   A CD2 1 
ATOM   1818 C  CE1 . TYR   A 1 268 ? 4.534   -38.080 -32.979 1.00 31.40  ? 531  TYR   A CE1 1 
ATOM   1819 C  CE2 . TYR   A 1 268 ? 5.658   -38.082 -30.885 1.00 31.55  ? 531  TYR   A CE2 1 
ATOM   1820 C  CZ  . TYR   A 1 268 ? 5.705   -38.181 -32.258 1.00 33.10  ? 531  TYR   A CZ  1 
ATOM   1821 O  OH  . TYR   A 1 268 ? 6.887   -38.399 -32.915 1.00 30.66  ? 531  TYR   A OH  1 
ATOM   1822 N  N   . ALA   A 1 269 ? 0.116   -39.046 -27.862 1.00 30.12  ? 532  ALA   A N   1 
ATOM   1823 C  CA  . ALA   A 1 269 ? -1.021  -38.960 -26.940 1.00 30.81  ? 532  ALA   A CA  1 
ATOM   1824 C  C   . ALA   A 1 269 ? -0.479  -38.391 -25.651 1.00 32.45  ? 532  ALA   A C   1 
ATOM   1825 O  O   . ALA   A 1 269 ? -0.457  -39.118 -24.667 1.00 35.57  ? 532  ALA   A O   1 
ATOM   1826 C  CB  . ALA   A 1 269 ? -1.673  -40.312 -26.743 1.00 30.82  ? 532  ALA   A CB  1 
ATOM   1827 N  N   . ASP   A 1 270 ? -0.073  -37.135 -25.668 1.00 29.79  ? 533  ASP   A N   1 
ATOM   1828 C  CA  . ASP   A 1 270 ? 0.425   -36.475 -24.446 1.00 32.69  ? 533  ASP   A CA  1 
ATOM   1829 C  C   . ASP   A 1 270 ? -0.771  -35.967 -23.648 1.00 36.72  ? 533  ASP   A C   1 
ATOM   1830 O  O   . ASP   A 1 270 ? -1.559  -35.204 -24.188 1.00 37.70  ? 533  ASP   A O   1 
ATOM   1831 C  CB  . ASP   A 1 270 ? 1.379   -35.331 -24.785 1.00 32.36  ? 533  ASP   A CB  1 
ATOM   1832 C  CG  . ASP   A 1 270 ? 2.578   -35.802 -25.600 1.00 36.11  ? 533  ASP   A CG  1 
ATOM   1833 O  OD1 . ASP   A 1 270 ? 2.874   -37.036 -25.536 1.00 35.70  ? 533  ASP   A OD1 1 
ATOM   1834 O  OD2 . ASP   A 1 270 ? 3.192   -34.963 -26.310 1.00 31.59  ? 533  ASP   A OD2 1 
ATOM   1835 N  N   . ASP   A 1 271 ? -0.895  -36.406 -22.394 0.50 36.40  ? 534  ASP   A N   1 
ATOM   1836 C  CA  . ASP   A 1 271 ? -1.865  -35.867 -21.405 0.50 36.68  ? 534  ASP   A CA  1 
ATOM   1837 C  C   . ASP   A 1 271 ? -1.294  -34.572 -20.821 0.50 35.61  ? 534  ASP   A C   1 
ATOM   1838 O  O   . ASP   A 1 271 ? -0.072  -34.507 -20.615 0.50 34.56  ? 534  ASP   A O   1 
ATOM   1839 C  CB  . ASP   A 1 271 ? -2.168  -36.888 -20.308 0.50 37.25  ? 534  ASP   A CB  1 
ATOM   1840 C  CG  . ASP   A 1 271 ? -3.119  -37.981 -20.762 0.50 38.63  ? 534  ASP   A CG  1 
ATOM   1841 O  OD1 . ASP   A 1 271 ? -4.018  -37.671 -21.571 0.50 35.65  ? 534  ASP   A OD1 1 
ATOM   1842 O  OD2 . ASP   A 1 271 ? -2.958  -39.130 -20.306 0.50 38.95  ? 534  ASP   A OD2 1 
ATOM   1843 N  N   . THR   A 1 272 ? -2.154  -33.583 -20.575 0.50 34.69  ? 535  THR   A N   1 
ATOM   1844 C  CA  . THR   A 1 272 ? -1.799  -32.303 -19.918 0.50 33.88  ? 535  THR   A CA  1 
ATOM   1845 C  C   . THR   A 1 272 ? -1.916  -32.490 -18.407 0.50 35.17  ? 535  THR   A C   1 
ATOM   1846 O  O   . THR   A 1 272 ? -2.832  -33.209 -17.973 0.50 37.76  ? 535  THR   A O   1 
ATOM   1847 C  CB  . THR   A 1 272 ? -2.676  -31.164 -20.442 0.50 34.46  ? 535  THR   A CB  1 
ATOM   1848 O  OG1 . THR   A 1 272 ? -2.658  -31.264 -21.865 0.50 34.66  ? 535  THR   A OG1 1 
ATOM   1849 C  CG2 . THR   A 1 272 ? -2.202  -29.795 -20.008 0.50 34.28  ? 535  THR   A CG2 1 
ATOM   1850 N  N   . ALA   A 1 273 ? -0.996  -31.896 -17.647 1.00 36.64  ? 536  ALA   A N   1 
ATOM   1851 C  CA  . ALA   A 1 273 ? -1.063  -31.870 -16.168 1.00 41.28  ? 536  ALA   A CA  1 
ATOM   1852 C  C   . ALA   A 1 273 ? -2.141  -30.841 -15.761 1.00 40.13  ? 536  ALA   A C   1 
ATOM   1853 O  O   . ALA   A 1 273 ? -1.899  -29.652 -15.973 1.00 47.59  ? 536  ALA   A O   1 
ATOM   1854 C  CB  . ALA   A 1 273 ? 0.315   -31.551 -15.612 1.00 38.80  ? 536  ALA   A CB  1 
ATOM   1855 N  N   . GLY   A 1 274 ? -3.297  -31.305 -15.275 1.00 43.97  ? 537  GLY   A N   1 
ATOM   1856 C  CA  . GLY   A 1 274 ? -4.423  -30.480 -14.778 1.00 43.23  ? 537  GLY   A CA  1 
ATOM   1857 C  C   . GLY   A 1 274 ? -4.903  -29.464 -15.800 1.00 41.82  ? 537  GLY   A C   1 
ATOM   1858 O  O   . GLY   A 1 274 ? -4.873  -28.243 -15.516 1.00 43.10  ? 537  GLY   A O   1 
ATOM   1859 N  N   . TRP   A 1 275 ? -5.395  -29.952 -16.931 1.00 38.22  ? 538  TRP   A N   1 
ATOM   1860 C  CA  . TRP   A 1 275 ? -5.959  -29.124 -18.025 1.00 37.60  ? 538  TRP   A CA  1 
ATOM   1861 C  C   . TRP   A 1 275 ? -6.795  -27.933 -17.534 1.00 38.13  ? 538  TRP   A C   1 
ATOM   1862 O  O   . TRP   A 1 275 ? -6.501  -26.819 -17.941 1.00 37.19  ? 538  TRP   A O   1 
ATOM   1863 C  CB  . TRP   A 1 275 ? -6.778  -29.965 -18.984 1.00 32.47  ? 538  TRP   A CB  1 
ATOM   1864 C  CG  . TRP   A 1 275 ? -7.345  -29.133 -20.089 1.00 32.90  ? 538  TRP   A CG  1 
ATOM   1865 C  CD1 . TRP   A 1 275 ? -8.552  -28.504 -20.087 1.00 33.88  ? 538  TRP   A CD1 1 
ATOM   1866 C  CD2 . TRP   A 1 275 ? -6.748  -28.850 -21.367 1.00 31.69  ? 538  TRP   A CD2 1 
ATOM   1867 N  NE1 . TRP   A 1 275 ? -8.737  -27.841 -21.269 1.00 37.15  ? 538  TRP   A NE1 1 
ATOM   1868 C  CE2 . TRP   A 1 275 ? -7.655  -28.032 -22.077 1.00 33.70  ? 538  TRP   A CE2 1 
ATOM   1869 C  CE3 . TRP   A 1 275 ? -5.550  -29.204 -21.987 1.00 28.29  ? 538  TRP   A CE3 1 
ATOM   1870 C  CZ2 . TRP   A 1 275 ? -7.410  -27.558 -23.363 1.00 33.12  ? 538  TRP   A CZ2 1 
ATOM   1871 C  CZ3 . TRP   A 1 275 ? -5.293  -28.710 -23.249 1.00 31.76  ? 538  TRP   A CZ3 1 
ATOM   1872 C  CH2 . TRP   A 1 275 ? -6.222  -27.932 -23.942 1.00 31.99  ? 538  TRP   A CH2 1 
ATOM   1873 N  N   . ASP   A 1 276 ? -7.817  -28.176 -16.706 0.50 36.73  ? 539  ASP   A N   1 
ATOM   1874 C  CA  . ASP   A 1 276 ? -8.806  -27.142 -16.286 0.50 37.97  ? 539  ASP   A CA  1 
ATOM   1875 C  C   . ASP   A 1 276 ? -8.079  -25.994 -15.566 0.50 40.18  ? 539  ASP   A C   1 
ATOM   1876 O  O   . ASP   A 1 276 ? -8.521  -24.837 -15.713 0.50 38.29  ? 539  ASP   A O   1 
ATOM   1877 C  CB  . ASP   A 1 276 ? -9.932  -27.738 -15.436 0.50 36.32  ? 539  ASP   A CB  1 
ATOM   1878 C  CG  . ASP   A 1 276 ? -11.075 -28.353 -16.236 0.50 37.41  ? 539  ASP   A CG  1 
ATOM   1879 O  OD1 . ASP   A 1 276 ? -10.952 -28.440 -17.473 0.50 37.04  ? 539  ASP   A OD1 1 
ATOM   1880 O  OD2 . ASP   A 1 276 ? -12.089 -28.749 -15.612 0.50 35.33  ? 539  ASP   A OD2 1 
ATOM   1881 N  N   . THR   A 1 277 ? -6.985  -26.283 -14.849 0.50 41.43  ? 540  THR   A N   1 
ATOM   1882 C  CA  . THR   A 1 277 ? -6.210  -25.276 -14.066 0.50 43.57  ? 540  THR   A CA  1 
ATOM   1883 C  C   . THR   A 1 277 ? -5.287  -24.458 -14.980 0.50 43.40  ? 540  THR   A C   1 
ATOM   1884 O  O   . THR   A 1 277 ? -4.840  -23.383 -14.533 0.50 47.16  ? 540  THR   A O   1 
ATOM   1885 C  CB  . THR   A 1 277 ? -5.410  -25.933 -12.934 0.50 44.55  ? 540  THR   A CB  1 
ATOM   1886 O  OG1 . THR   A 1 277 ? -4.357  -26.705 -13.510 0.50 47.54  ? 540  THR   A OG1 1 
ATOM   1887 C  CG2 . THR   A 1 277 ? -6.271  -26.806 -12.049 0.50 46.37  ? 540  THR   A CG2 1 
ATOM   1888 N  N   . ARG   A 1 278 ? -5.018  -24.936 -16.200 1.00 41.57  ? 541  ARG   A N   1 
ATOM   1889 C  CA  . ARG   A 1 278 ? -4.095  -24.279 -17.158 1.00 37.07  ? 541  ARG   A CA  1 
ATOM   1890 C  C   . ARG   A 1 278 ? -4.851  -23.486 -18.214 1.00 37.61  ? 541  ARG   A C   1 
ATOM   1891 O  O   . ARG   A 1 278 ? -4.208  -23.151 -19.212 1.00 36.17  ? 541  ARG   A O   1 
ATOM   1892 C  CB  . ARG   A 1 278 ? -3.307  -25.320 -17.958 1.00 41.42  ? 541  ARG   A CB  1 
ATOM   1893 C  CG  . ARG   A 1 278 ? -2.715  -26.427 -17.111 1.00 46.55  ? 541  ARG   A CG  1 
ATOM   1894 C  CD  . ARG   A 1 278 ? -1.389  -26.004 -16.568 1.00 50.59  ? 541  ARG   A CD  1 
ATOM   1895 N  NE  . ARG   A 1 278 ? -0.839  -26.978 -15.634 1.00 65.36  ? 541  ARG   A NE  1 
ATOM   1896 C  CZ  . ARG   A 1 278 ? 0.424   -26.984 -15.209 1.00 57.32  ? 541  ARG   A CZ  1 
ATOM   1897 N  NH1 . ARG   A 1 278 ? 1.289   -26.101 -15.684 1.00 57.90  ? 541  ARG   A NH1 1 
ATOM   1898 N  NH2 . ARG   A 1 278 ? 0.807   -27.866 -14.305 1.00 56.29  ? 541  ARG   A NH2 1 
ATOM   1899 N  N   . ILE   A 1 279 ? -6.173  -23.338 -18.095 1.00 35.82  ? 542  ILE   A N   1 
ATOM   1900 C  CA  . ILE   A 1 279 ? -6.965  -22.515 -19.050 1.00 38.15  ? 542  ILE   A CA  1 
ATOM   1901 C  C   . ILE   A 1 279 ? -6.747  -21.027 -18.713 1.00 36.73  ? 542  ILE   A C   1 
ATOM   1902 O  O   . ILE   A 1 279 ? -7.042  -20.601 -17.583 1.00 39.02  ? 542  ILE   A O   1 
ATOM   1903 C  CB  . ILE   A 1 279 ? -8.440  -22.967 -19.029 1.00 40.16  ? 542  ILE   A CB  1 
ATOM   1904 C  CG1 . ILE   A 1 279 ? -8.601  -24.303 -19.749 1.00 40.19  ? 542  ILE   A CG1 1 
ATOM   1905 C  CG2 . ILE   A 1 279 ? -9.367  -21.921 -19.629 1.00 37.98  ? 542  ILE   A CG2 1 
ATOM   1906 C  CD1 . ILE   A 1 279 ? -8.507  -24.167 -21.260 1.00 41.57  ? 542  ILE   A CD1 1 
ATOM   1907 N  N   . THR   A 1 280 ? -6.173  -20.284 -19.652 1.00 43.13  ? 543  THR   A N   1 
ATOM   1908 C  CA  . THR   A 1 280 ? -5.760  -18.866 -19.504 1.00 43.19  ? 543  THR   A CA  1 
ATOM   1909 C  C   . THR   A 1 280 ? -6.964  -17.975 -19.807 1.00 47.25  ? 543  THR   A C   1 
ATOM   1910 O  O   . THR   A 1 280 ? -7.869  -18.428 -20.548 1.00 44.78  ? 543  THR   A O   1 
ATOM   1911 C  CB  . THR   A 1 280 ? -4.611  -18.530 -20.458 1.00 41.53  ? 543  THR   A CB  1 
ATOM   1912 O  OG1 . THR   A 1 280 ? -5.086  -18.682 -21.790 1.00 39.62  ? 543  THR   A OG1 1 
ATOM   1913 C  CG2 . THR   A 1 280 ? -3.415  -19.432 -20.293 1.00 44.67  ? 543  THR   A CG2 1 
ATOM   1914 N  N   . LEU   A 1 281 ? -6.966  -16.739 -19.311 1.00 52.57  ? 544  LEU   A N   1 
ATOM   1915 C  CA  . LEU   A 1 281 ? -7.983  -15.736 -19.730 1.00 52.49  ? 544  LEU   A CA  1 
ATOM   1916 C  C   . LEU   A 1 281 ? -7.923  -15.594 -21.264 1.00 46.29  ? 544  LEU   A C   1 
ATOM   1917 O  O   . LEU   A 1 281 ? -8.974  -15.479 -21.878 1.00 41.39  ? 544  LEU   A O   1 
ATOM   1918 C  CB  . LEU   A 1 281 ? -7.741  -14.403 -19.008 1.00 62.71  ? 544  LEU   A CB  1 
ATOM   1919 C  CG  . LEU   A 1 281 ? -8.668  -13.249 -19.416 1.00 70.49  ? 544  LEU   A CG  1 
ATOM   1920 C  CD1 . LEU   A 1 281 ? -10.145 -13.623 -19.277 1.00 59.78  ? 544  LEU   A CD1 1 
ATOM   1921 C  CD2 . LEU   A 1 281 ? -8.358  -11.992 -18.613 1.00 74.58  ? 544  LEU   A CD2 1 
ATOM   1922 N  N   . GLU   A 1 282 ? -6.745  -15.695 -21.880 1.00 46.34  ? 545  GLU   A N   1 
ATOM   1923 C  CA  . GLU   A 1 282 ? -6.618  -15.653 -23.365 1.00 46.26  ? 545  GLU   A CA  1 
ATOM   1924 C  C   . GLU   A 1 282 ? -7.390  -16.824 -24.014 1.00 44.39  ? 545  GLU   A C   1 
ATOM   1925 O  O   . GLU   A 1 282 ? -8.141  -16.620 -25.018 1.00 37.41  ? 545  GLU   A O   1 
ATOM   1926 C  CB  . GLU   A 1 282 ? -5.136  -15.642 -23.729 1.00 52.32  ? 545  GLU   A CB  1 
ATOM   1927 C  CG  . GLU   A 1 282 ? -4.871  -14.929 -25.039 1.00 64.16  ? 545  GLU   A CG  1 
ATOM   1928 C  CD  . GLU   A 1 282 ? -5.146  -13.429 -25.056 1.00 64.82  ? 545  GLU   A CD  1 
ATOM   1929 O  OE1 . GLU   A 1 282 ? -5.386  -12.833 -23.970 1.00 63.02  ? 545  GLU   A OE1 1 
ATOM   1930 O  OE2 . GLU   A 1 282 ? -5.135  -12.866 -26.170 1.00 69.93  ? 545  GLU   A OE2 1 
ATOM   1931 N  N   . ASP   A 1 283 ? -7.268  -18.031 -23.467 1.00 40.43  ? 546  ASP   A N   1 
ATOM   1932 C  CA  . ASP   A 1 283 ? -8.136  -19.165 -23.893 1.00 39.76  ? 546  ASP   A CA  1 
ATOM   1933 C  C   . ASP   A 1 283 ? -9.632  -18.779 -23.733 1.00 38.68  ? 546  ASP   A C   1 
ATOM   1934 O  O   . ASP   A 1 283 ? -10.404 -18.947 -24.729 1.00 39.23  ? 546  ASP   A O   1 
ATOM   1935 C  CB  . ASP   A 1 283 ? -7.822  -20.439 -23.108 1.00 35.08  ? 546  ASP   A CB  1 
ATOM   1936 C  CG  . ASP   A 1 283 ? -6.449  -21.029 -23.362 1.00 33.30  ? 546  ASP   A CG  1 
ATOM   1937 O  OD1 . ASP   A 1 283 ? -5.934  -20.917 -24.494 1.00 34.66  ? 546  ASP   A OD1 1 
ATOM   1938 O  OD2 . ASP   A 1 283 ? -5.923  -21.628 -22.416 1.00 34.68  ? 546  ASP   A OD2 1 
ATOM   1939 N  N   . LEU   A 1 284 ? -10.055 -18.309 -22.549 1.00 35.85  ? 547  LEU   A N   1 
ATOM   1940 C  CA  . LEU   A 1 284 ? -11.484 -17.916 -22.283 1.00 37.92  ? 547  LEU   A CA  1 
ATOM   1941 C  C   . LEU   A 1 284 ? -11.994 -16.863 -23.296 1.00 39.90  ? 547  LEU   A C   1 
ATOM   1942 O  O   . LEU   A 1 284 ? -13.162 -16.964 -23.705 1.00 40.85  ? 547  LEU   A O   1 
ATOM   1943 C  CB  . LEU   A 1 284 ? -11.622 -17.401 -20.851 1.00 35.10  ? 547  LEU   A CB  1 
ATOM   1944 C  CG  . LEU   A 1 284 ? -11.432 -18.452 -19.764 1.00 37.56  ? 547  LEU   A CG  1 
ATOM   1945 C  CD1 . LEU   A 1 284 ? -11.446 -17.814 -18.390 1.00 43.39  ? 547  LEU   A CD1 1 
ATOM   1946 C  CD2 . LEU   A 1 284 ? -12.491 -19.553 -19.812 1.00 34.40  ? 547  LEU   A CD2 1 
ATOM   1947 N  N   . LYS   A 1 285 ? -11.132 -15.947 -23.760 1.00 43.05  ? 548  LYS   A N   1 
ATOM   1948 C  CA  . LYS   A 1 285 ? -11.461 -14.915 -24.776 1.00 44.52  ? 548  LYS   A CA  1 
ATOM   1949 C  C   . LYS   A 1 285 ? -11.604 -15.537 -26.172 1.00 43.61  ? 548  LYS   A C   1 
ATOM   1950 O  O   . LYS   A 1 285 ? -12.521 -15.135 -26.893 1.00 49.46  ? 548  LYS   A O   1 
ATOM   1951 C  CB  . LYS   A 1 285 ? -10.437 -13.778 -24.713 1.00 46.74  ? 548  LYS   A CB  1 
ATOM   1952 C  CG  . LYS   A 1 285 ? -10.610 -12.901 -23.481 1.00 51.43  ? 548  LYS   A CG  1 
ATOM   1953 C  CD  . LYS   A 1 285 ? -9.673  -11.713 -23.445 1.00 61.82  ? 548  LYS   A CD  1 
ATOM   1954 C  CE  . LYS   A 1 285 ? -10.183 -10.567 -22.595 1.00 69.14  ? 548  LYS   A CE  1 
ATOM   1955 N  NZ  . LYS   A 1 285 ? -9.073  -9.671  -22.184 1.00 82.75  ? 548  LYS   A NZ  1 
ATOM   1956 N  N   . ASN   A 1 286 ? -10.761 -16.481 -26.563 1.00 40.81  ? 549  ASN   A N   1 
ATOM   1957 C  CA  . ASN   A 1 286 ? -10.893 -17.152 -27.886 1.00 40.72  ? 549  ASN   A CA  1 
ATOM   1958 C  C   . ASN   A 1 286 ? -12.149 -18.041 -27.922 1.00 36.77  ? 549  ASN   A C   1 
ATOM   1959 O  O   . ASN   A 1 286 ? -12.753 -18.160 -28.989 1.00 36.69  ? 549  ASN   A O   1 
ATOM   1960 C  CB  . ASN   A 1 286 ? -9.608  -17.913 -28.205 1.00 41.95  ? 549  ASN   A CB  1 
ATOM   1961 C  CG  . ASN   A 1 286 ? -8.429  -16.963 -28.314 1.00 43.29  ? 549  ASN   A CG  1 
ATOM   1962 O  OD1 . ASN   A 1 286 ? -8.492  -15.930 -28.977 1.00 41.35  ? 549  ASN   A OD1 1 
ATOM   1963 N  ND2 . ASN   A 1 286 ? -7.354  -17.274 -27.635 1.00 45.64  ? 549  ASN   A ND2 1 
ATOM   1964 N  N   . GLU   A 1 287 ? -12.533 -18.655 -26.807 1.00 37.45  ? 550  GLU   A N   1 
ATOM   1965 C  CA  . GLU   A 1 287 ? -13.784 -19.469 -26.695 1.00 41.82  ? 550  GLU   A CA  1 
ATOM   1966 C  C   . GLU   A 1 287 ? -15.009 -18.553 -26.880 1.00 38.92  ? 550  GLU   A C   1 
ATOM   1967 O  O   . GLU   A 1 287 ? -15.911 -18.929 -27.642 1.00 39.86  ? 550  GLU   A O   1 
ATOM   1968 C  CB  . GLU   A 1 287 ? -13.788 -20.225 -25.362 1.00 38.87  ? 550  GLU   A CB  1 
ATOM   1969 C  CG  . GLU   A 1 287 ? -12.729 -21.305 -25.334 1.00 40.13  ? 550  GLU   A CG  1 
ATOM   1970 C  CD  . GLU   A 1 287 ? -12.375 -21.865 -23.970 1.00 46.48  ? 550  GLU   A CD  1 
ATOM   1971 O  OE1 . GLU   A 1 287 ? -13.074 -21.544 -22.972 1.00 48.86  ? 550  GLU   A OE1 1 
ATOM   1972 O  OE2 . GLU   A 1 287 ? -11.423 -22.663 -23.906 1.00 44.08  ? 550  GLU   A OE2 1 
ATOM   1973 N  N   . GLU   A 1 288 ? -14.983 -17.369 -26.272 1.00 36.52  ? 551  GLU   A N   1 
ATOM   1974 C  CA  . GLU   A 1 288 ? -16.026 -16.311 -26.362 1.00 37.83  ? 551  GLU   A CA  1 
ATOM   1975 C  C   . GLU   A 1 288 ? -16.269 -15.916 -27.822 1.00 37.79  ? 551  GLU   A C   1 
ATOM   1976 O  O   . GLU   A 1 288 ? -17.385 -15.527 -28.148 1.00 39.12  ? 551  GLU   A O   1 
ATOM   1977 C  CB  . GLU   A 1 288 ? -15.610 -15.115 -25.506 1.00 45.53  ? 551  GLU   A CB  1 
ATOM   1978 C  CG  . GLU   A 1 288 ? -16.736 -14.161 -25.140 1.00 52.24  ? 551  GLU   A CG  1 
ATOM   1979 C  CD  . GLU   A 1 288 ? -16.957 -12.947 -26.043 1.00 57.62  ? 551  GLU   A CD  1 
ATOM   1980 O  OE1 . GLU   A 1 288 ? -16.207 -12.784 -27.014 1.00 56.13  ? 551  GLU   A OE1 1 
ATOM   1981 O  OE2 . GLU   A 1 288 ? -17.887 -12.149 -25.762 1.00 66.48  ? 551  GLU   A OE2 1 
ATOM   1982 N  N   . MET   A 1 289 ? -15.309 -16.090 -28.717 1.00 35.40  ? 552  MET   A N   1 
ATOM   1983 C  CA  . MET   A 1 289 ? -15.515 -15.638 -30.111 1.00 37.68  ? 552  MET   A CA  1 
ATOM   1984 C  C   . MET   A 1 289 ? -16.618 -16.462 -30.767 1.00 37.48  ? 552  MET   A C   1 
ATOM   1985 O  O   . MET   A 1 289 ? -17.000 -16.106 -31.923 1.00 41.69  ? 552  MET   A O   1 
ATOM   1986 C  CB  . MET   A 1 289 ? -14.236 -15.728 -30.950 1.00 36.89  ? 552  MET   A CB  1 
ATOM   1987 C  CG  . MET   A 1 289 ? -13.182 -14.742 -30.465 1.00 42.65  ? 552  MET   A CG  1 
ATOM   1988 S  SD  . MET   A 1 289 ? -11.808 -14.465 -31.638 1.00 51.28  ? 552  MET   A SD  1 
ATOM   1989 C  CE  . MET   A 1 289 ? -11.518 -16.061 -32.382 1.00 50.35  ? 552  MET   A CE  1 
ATOM   1990 N  N   . VAL   A 1 290 ? -17.099 -17.544 -30.144 1.00 35.75  ? 553  VAL   A N   1 
ATOM   1991 C  CA  . VAL   A 1 290 ? -18.307 -18.248 -30.689 1.00 36.06  ? 553  VAL   A CA  1 
ATOM   1992 C  C   . VAL   A 1 290 ? -19.487 -17.265 -30.692 1.00 35.87  ? 553  VAL   A C   1 
ATOM   1993 O  O   . VAL   A 1 290 ? -20.304 -17.405 -31.591 1.00 37.89  ? 553  VAL   A O   1 
ATOM   1994 C  CB  . VAL   A 1 290 ? -18.681 -19.553 -29.962 1.00 33.00  ? 553  VAL   A CB  1 
ATOM   1995 C  CG1 . VAL   A 1 290 ? -19.125 -19.331 -28.530 1.00 34.40  ? 553  VAL   A CG1 1 
ATOM   1996 C  CG2 . VAL   A 1 290 ? -19.739 -20.340 -30.709 1.00 33.31  ? 553  VAL   A CG2 1 
ATOM   1997 N  N   . THR   A 1 291 ? -19.568 -16.300 -29.762 1.00 34.86  ? 554  THR   A N   1 
ATOM   1998 C  CA  . THR   A 1 291 ? -20.671 -15.289 -29.761 1.00 39.42  ? 554  THR   A CA  1 
ATOM   1999 C  C   . THR   A 1 291 ? -20.686 -14.475 -31.066 1.00 39.58  ? 554  THR   A C   1 
ATOM   2000 O  O   . THR   A 1 291 ? -21.797 -14.018 -31.481 1.00 38.90  ? 554  THR   A O   1 
ATOM   2001 C  CB  . THR   A 1 291 ? -20.594 -14.335 -28.575 1.00 36.45  ? 554  THR   A CB  1 
ATOM   2002 O  OG1 . THR   A 1 291 ? -19.332 -13.663 -28.622 1.00 38.02  ? 554  THR   A OG1 1 
ATOM   2003 C  CG2 . THR   A 1 291 ? -20.770 -15.055 -27.266 1.00 33.27  ? 554  THR   A CG2 1 
ATOM   2004 N  N   . ASN   A 1 292 ? -19.545 -14.343 -31.745 1.00 39.68  ? 555  ASN   A N   1 
ATOM   2005 C  CA  . ASN   A 1 292 ? -19.477 -13.644 -33.060 1.00 41.66  ? 555  ASN   A CA  1 
ATOM   2006 C  C   . ASN   A 1 292 ? -20.353 -14.329 -34.106 1.00 45.82  ? 555  ASN   A C   1 
ATOM   2007 O  O   . ASN   A 1 292 ? -20.525 -13.709 -35.176 1.00 53.56  ? 555  ASN   A O   1 
ATOM   2008 C  CB  . ASN   A 1 292 ? -18.095 -13.610 -33.705 1.00 41.10  ? 555  ASN   A CB  1 
ATOM   2009 C  CG  . ASN   A 1 292 ? -17.113 -12.853 -32.854 1.00 42.57  ? 555  ASN   A CG  1 
ATOM   2010 O  OD1 . ASN   A 1 292 ? -17.520 -12.173 -31.932 1.00 52.29  ? 555  ASN   A OD1 1 
ATOM   2011 N  ND2 . ASN   A 1 292 ? -15.835 -13.012 -33.126 1.00 44.88  ? 555  ASN   A ND2 1 
ATOM   2012 N  N   . HIS   A 1 293 ? -20.809 -15.566 -33.879 1.00 40.25  ? 556  HIS   A N   1 
ATOM   2013 C  CA  . HIS   A 1 293 ? -21.581 -16.346 -34.891 1.00 43.28  ? 556  HIS   A CA  1 
ATOM   2014 C  C   . HIS   A 1 293 ? -23.077 -16.292 -34.566 1.00 37.60  ? 556  HIS   A C   1 
ATOM   2015 O  O   . HIS   A 1 293 ? -23.864 -16.950 -35.269 1.00 39.16  ? 556  HIS   A O   1 
ATOM   2016 C  CB  . HIS   A 1 293 ? -20.997 -17.759 -35.025 1.00 43.63  ? 556  HIS   A CB  1 
ATOM   2017 C  CG  . HIS   A 1 293 ? -19.592 -17.698 -35.516 1.00 44.63  ? 556  HIS   A CG  1 
ATOM   2018 N  ND1 . HIS   A 1 293 ? -19.276 -17.898 -36.833 1.00 43.66  ? 556  HIS   A ND1 1 
ATOM   2019 C  CD2 . HIS   A 1 293 ? -18.435 -17.372 -34.888 1.00 49.19  ? 556  HIS   A CD2 1 
ATOM   2020 C  CE1 . HIS   A 1 293 ? -17.980 -17.715 -37.006 1.00 44.64  ? 556  HIS   A CE1 1 
ATOM   2021 N  NE2 . HIS   A 1 293 ? -17.443 -17.384 -35.835 1.00 46.14  ? 556  HIS   A NE2 1 
ATOM   2022 N  N   . MET   A 1 294 ? -23.423 -15.553 -33.517 1.00 38.88  ? 557  MET   A N   1 
ATOM   2023 C  CA  . MET   A 1 294 ? -24.769 -15.499 -32.905 1.00 43.57  ? 557  MET   A CA  1 
ATOM   2024 C  C   . MET   A 1 294 ? -25.437 -14.171 -33.273 1.00 45.01  ? 557  MET   A C   1 
ATOM   2025 O  O   . MET   A 1 294 ? -24.779 -13.303 -33.828 1.00 45.33  ? 557  MET   A O   1 
ATOM   2026 C  CB  . MET   A 1 294 ? -24.675 -15.573 -31.380 1.00 44.16  ? 557  MET   A CB  1 
ATOM   2027 C  CG  . MET   A 1 294 ? -24.141 -16.901 -30.865 1.00 44.28  ? 557  MET   A CG  1 
ATOM   2028 S  SD  . MET   A 1 294 ? -24.105 -16.935 -29.065 1.00 41.23  ? 557  MET   A SD  1 
ATOM   2029 C  CE  . MET   A 1 294 ? -23.129 -18.427 -28.854 1.00 42.86  ? 557  MET   A CE  1 
ATOM   2030 N  N   . GLU   A 1 295 ? -26.694 -14.006 -32.891 1.00 50.00  ? 558  GLU   A N   1 
ATOM   2031 C  CA  . GLU   A 1 295 ? -27.446 -12.771 -33.186 1.00 53.62  ? 558  GLU   A CA  1 
ATOM   2032 C  C   . GLU   A 1 295 ? -28.478 -12.489 -32.107 1.00 52.41  ? 558  GLU   A C   1 
ATOM   2033 O  O   . GLU   A 1 295 ? -28.781 -13.399 -31.284 1.00 51.48  ? 558  GLU   A O   1 
ATOM   2034 C  CB  . GLU   A 1 295 ? -28.143 -12.912 -34.526 1.00 57.59  ? 558  GLU   A CB  1 
ATOM   2035 C  CG  . GLU   A 1 295 ? -29.159 -14.019 -34.574 1.00 60.06  ? 558  GLU   A CG  1 
ATOM   2036 C  CD  . GLU   A 1 295 ? -29.829 -14.067 -35.928 1.00 69.43  ? 558  GLU   A CD  1 
ATOM   2037 O  OE1 . GLU   A 1 295 ? -29.099 -14.056 -36.963 1.00 75.20  ? 558  GLU   A OE1 1 
ATOM   2038 O  OE2 . GLU   A 1 295 ? -31.071 -14.064 -35.944 1.00 80.05  ? 558  GLU   A OE2 1 
ATOM   2039 N  N   . GLY   A 1 296 ? -28.968 -11.253 -32.146 1.00 55.08  ? 559  GLY   A N   1 
ATOM   2040 C  CA  . GLY   A 1 296 ? -30.062 -10.751 -31.310 1.00 49.80  ? 559  GLY   A CA  1 
ATOM   2041 C  C   . GLY   A 1 296 ? -29.798 -11.051 -29.857 1.00 49.73  ? 559  GLY   A C   1 
ATOM   2042 O  O   . GLY   A 1 296 ? -28.635 -10.828 -29.395 1.00 43.64  ? 559  GLY   A O   1 
ATOM   2043 N  N   . GLU   A 1 297 ? -30.839 -11.570 -29.208 1.00 45.55  ? 560  GLU   A N   1 
ATOM   2044 C  CA  . GLU   A 1 297 ? -30.909 -11.877 -27.762 1.00 55.22  ? 560  GLU   A CA  1 
ATOM   2045 C  C   . GLU   A 1 297 ? -29.808 -12.886 -27.389 1.00 54.13  ? 560  GLU   A C   1 
ATOM   2046 O  O   . GLU   A 1 297 ? -29.059 -12.630 -26.426 1.00 55.32  ? 560  GLU   A O   1 
ATOM   2047 C  CB  . GLU   A 1 297 ? -32.301 -12.428 -27.478 1.00 58.55  ? 560  GLU   A CB  1 
ATOM   2048 C  CG  . GLU   A 1 297 ? -32.475 -12.913 -26.058 1.00 72.50  ? 560  GLU   A CG  1 
ATOM   2049 C  CD  . GLU   A 1 297 ? -33.902 -12.813 -25.554 1.00 79.87  ? 560  GLU   A CD  1 
ATOM   2050 O  OE1 . GLU   A 1 297 ? -34.408 -13.805 -24.963 1.00 83.17  ? 560  GLU   A OE1 1 
ATOM   2051 O  OE2 . GLU   A 1 297 ? -34.493 -11.734 -25.736 1.00 84.92  ? 560  GLU   A OE2 1 
ATOM   2052 N  N   . HIS   A 1 298 ? -29.740 -13.993 -28.122 1.00 49.16  ? 561  HIS   A N   1 
ATOM   2053 C  CA  . HIS   A 1 298 ? -28.803 -15.116 -27.886 1.00 50.52  ? 561  HIS   A CA  1 
ATOM   2054 C  C   . HIS   A 1 298 ? -27.392 -14.538 -27.686 1.00 49.46  ? 561  HIS   A C   1 
ATOM   2055 O  O   . HIS   A 1 298 ? -26.786 -14.775 -26.628 1.00 51.92  ? 561  HIS   A O   1 
ATOM   2056 C  CB  . HIS   A 1 298 ? -28.913 -16.135 -29.018 1.00 47.87  ? 561  HIS   A CB  1 
ATOM   2057 C  CG  . HIS   A 1 298 ? -28.068 -17.350 -28.793 1.00 51.30  ? 561  HIS   A CG  1 
ATOM   2058 N  ND1 . HIS   A 1 298 ? -27.691 -18.193 -29.823 1.00 48.89  ? 561  HIS   A ND1 1 
ATOM   2059 C  CD2 . HIS   A 1 298 ? -27.564 -17.884 -27.657 1.00 46.07  ? 561  HIS   A CD2 1 
ATOM   2060 C  CE1 . HIS   A 1 298 ? -26.980 -19.179 -29.329 1.00 50.41  ? 561  HIS   A CE1 1 
ATOM   2061 N  NE2 . HIS   A 1 298 ? -26.895 -19.014 -28.001 1.00 49.73  ? 561  HIS   A NE2 1 
ATOM   2062 N  N   . LYS   A 1 299 ? -26.904 -13.772 -28.667 0.50 48.27  ? 562  LYS   A N   1 
ATOM   2063 C  CA  . LYS   A 1 299 ? -25.543 -13.175 -28.653 0.50 49.75  ? 562  LYS   A CA  1 
ATOM   2064 C  C   . LYS   A 1 299 ? -25.306 -12.461 -27.318 0.50 52.30  ? 562  LYS   A C   1 
ATOM   2065 O  O   . LYS   A 1 299 ? -24.201 -12.614 -26.760 0.50 51.47  ? 562  LYS   A O   1 
ATOM   2066 C  CB  . LYS   A 1 299 ? -25.344 -12.198 -29.814 0.50 48.43  ? 562  LYS   A CB  1 
ATOM   2067 C  CG  . LYS   A 1 299 ? -24.125 -11.298 -29.662 0.50 47.11  ? 562  LYS   A CG  1 
ATOM   2068 C  CD  . LYS   A 1 299 ? -23.613 -10.722 -30.963 0.50 47.83  ? 562  LYS   A CD  1 
ATOM   2069 C  CE  . LYS   A 1 299 ? -22.471 -9.748  -30.768 0.50 49.76  ? 562  LYS   A CE  1 
ATOM   2070 N  NZ  . LYS   A 1 299 ? -21.265 -10.411 -30.214 0.50 50.57  ? 562  LYS   A NZ  1 
ATOM   2071 N  N   . LYS   A 1 300 ? -26.306 -11.720 -26.829 1.00 53.70  ? 563  LYS   A N   1 
ATOM   2072 C  CA  . LYS   A 1 300 ? -26.186 -10.932 -25.566 1.00 62.02  ? 563  LYS   A CA  1 
ATOM   2073 C  C   . LYS   A 1 300 ? -26.162 -11.882 -24.371 1.00 48.43  ? 563  LYS   A C   1 
ATOM   2074 O  O   . LYS   A 1 300 ? -25.342 -11.675 -23.506 1.00 52.10  ? 563  LYS   A O   1 
ATOM   2075 C  CB  . LYS   A 1 300 ? -27.327 -9.918  -25.383 1.00 75.23  ? 563  LYS   A CB  1 
ATOM   2076 C  CG  . LYS   A 1 300 ? -27.573 -8.977  -26.558 1.00 86.00  ? 563  LYS   A CG  1 
ATOM   2077 C  CD  . LYS   A 1 300 ? -27.014 -7.575  -26.426 1.00 94.10  ? 563  LYS   A CD  1 
ATOM   2078 C  CE  . LYS   A 1 300 ? -27.918 -6.548  -27.087 1.00 100.72 ? 563  LYS   A CE  1 
ATOM   2079 N  NZ  . LYS   A 1 300 ? -27.320 -5.192  -27.140 1.00 101.55 ? 563  LYS   A NZ  1 
ATOM   2080 N  N   . LEU   A 1 301 ? -27.059 -12.860 -24.336 1.00 47.25  ? 564  LEU   A N   1 
ATOM   2081 C  CA  . LEU   A 1 301 ? -27.127 -13.869 -23.252 1.00 51.49  ? 564  LEU   A CA  1 
ATOM   2082 C  C   . LEU   A 1 301 ? -25.782 -14.635 -23.160 1.00 52.88  ? 564  LEU   A C   1 
ATOM   2083 O  O   . LEU   A 1 301 ? -25.225 -14.719 -22.034 1.00 48.55  ? 564  LEU   A O   1 
ATOM   2084 C  CB  . LEU   A 1 301 ? -28.311 -14.801 -23.532 1.00 50.64  ? 564  LEU   A CB  1 
ATOM   2085 C  CG  . LEU   A 1 301 ? -29.713 -14.206 -23.323 1.00 47.65  ? 564  LEU   A CG  1 
ATOM   2086 C  CD1 . LEU   A 1 301 ? -30.775 -15.193 -23.737 1.00 46.55  ? 564  LEU   A CD1 1 
ATOM   2087 C  CD2 . LEU   A 1 301 ? -29.959 -13.807 -21.881 1.00 48.22  ? 564  LEU   A CD2 1 
ATOM   2088 N  N   . ALA   A 1 302 ? -25.271 -15.144 -24.291 1.00 45.80  ? 565  ALA   A N   1 
ATOM   2089 C  CA  . ALA   A 1 302 ? -23.985 -15.874 -24.411 1.00 45.76  ? 565  ALA   A CA  1 
ATOM   2090 C  C   . ALA   A 1 302 ? -22.838 -14.984 -23.942 1.00 44.74  ? 565  ALA   A C   1 
ATOM   2091 O  O   . ALA   A 1 302 ? -21.981 -15.463 -23.195 1.00 48.69  ? 565  ALA   A O   1 
ATOM   2092 C  CB  . ALA   A 1 302 ? -23.733 -16.338 -25.831 1.00 44.82  ? 565  ALA   A CB  1 
ATOM   2093 N  N   . GLU   A 1 303 ? -22.822 -13.722 -24.384 0.50 45.02  ? 566  GLU   A N   1 
ATOM   2094 C  CA  . GLU   A 1 303 ? -21.785 -12.723 -24.008 0.50 45.08  ? 566  GLU   A CA  1 
ATOM   2095 C  C   . GLU   A 1 303 ? -21.770 -12.564 -22.484 0.50 43.56  ? 566  GLU   A C   1 
ATOM   2096 O  O   . GLU   A 1 303 ? -20.668 -12.488 -21.909 0.50 43.57  ? 566  GLU   A O   1 
ATOM   2097 C  CB  . GLU   A 1 303 ? -22.031 -11.372 -24.686 0.50 46.49  ? 566  GLU   A CB  1 
ATOM   2098 C  CG  . GLU   A 1 303 ? -21.780 -11.391 -26.181 0.50 47.50  ? 566  GLU   A CG  1 
ATOM   2099 C  CD  . GLU   A 1 303 ? -21.347 -10.065 -26.788 0.50 49.82  ? 566  GLU   A CD  1 
ATOM   2100 O  OE1 . GLU   A 1 303 ? -21.090 -9.113  -26.020 0.50 51.38  ? 566  GLU   A OE1 1 
ATOM   2101 O  OE2 . GLU   A 1 303 ? -21.259 -9.988  -28.036 0.50 50.51  ? 566  GLU   A OE2 1 
ATOM   2102 N  N   . ALA   A 1 304 ? -22.949 -12.529 -21.859 1.00 41.45  ? 567  ALA   A N   1 
ATOM   2103 C  CA  . ALA   A 1 304 ? -23.075 -12.357 -20.402 1.00 45.37  ? 567  ALA   A CA  1 
ATOM   2104 C  C   . ALA   A 1 304 ? -22.516 -13.596 -19.688 1.00 43.36  ? 567  ALA   A C   1 
ATOM   2105 O  O   . ALA   A 1 304 ? -21.760 -13.412 -18.720 1.00 44.71  ? 567  ALA   A O   1 
ATOM   2106 C  CB  . ALA   A 1 304 ? -24.507 -12.046 -20.020 1.00 45.67  ? 567  ALA   A CB  1 
ATOM   2107 N  N   . ILE   A 1 305 ? -22.834 -14.806 -20.156 1.00 44.75  ? 568  ILE   A N   1 
ATOM   2108 C  CA  . ILE   A 1 305 ? -22.324 -16.036 -19.495 1.00 42.59  ? 568  ILE   A CA  1 
ATOM   2109 C  C   . ILE   A 1 305 ? -20.794 -15.963 -19.550 1.00 44.21  ? 568  ILE   A C   1 
ATOM   2110 O  O   . ILE   A 1 305 ? -20.164 -16.070 -18.507 1.00 40.63  ? 568  ILE   A O   1 
ATOM   2111 C  CB  . ILE   A 1 305 ? -22.872 -17.315 -20.141 1.00 47.84  ? 568  ILE   A CB  1 
ATOM   2112 C  CG1 . ILE   A 1 305 ? -24.374 -17.470 -19.904 1.00 45.32  ? 568  ILE   A CG1 1 
ATOM   2113 C  CG2 . ILE   A 1 305 ? -22.090 -18.562 -19.682 1.00 46.66  ? 568  ILE   A CG2 1 
ATOM   2114 C  CD1 . ILE   A 1 305 ? -24.803 -17.489 -18.448 1.00 44.63  ? 568  ILE   A CD1 1 
ATOM   2115 N  N   . PHE   A 1 306 ? -20.218 -15.678 -20.710 1.00 42.59  ? 569  PHE   A N   1 
ATOM   2116 C  CA  . PHE   A 1 306 ? -18.745 -15.637 -20.901 1.00 47.69  ? 569  PHE   A CA  1 
ATOM   2117 C  C   . PHE   A 1 306 ? -18.094 -14.558 -20.015 1.00 53.79  ? 569  PHE   A C   1 
ATOM   2118 O  O   . PHE   A 1 306 ? -17.132 -14.864 -19.291 1.00 55.01  ? 569  PHE   A O   1 
ATOM   2119 C  CB  . PHE   A 1 306 ? -18.398 -15.445 -22.376 1.00 46.81  ? 569  PHE   A CB  1 
ATOM   2120 C  CG  . PHE   A 1 306 ? -18.218 -16.729 -23.140 1.00 45.76  ? 569  PHE   A CG  1 
ATOM   2121 C  CD1 . PHE   A 1 306 ? -17.068 -17.484 -22.980 1.00 47.96  ? 569  PHE   A CD1 1 
ATOM   2122 C  CD2 . PHE   A 1 306 ? -19.163 -17.153 -24.052 1.00 44.08  ? 569  PHE   A CD2 1 
ATOM   2123 C  CE1 . PHE   A 1 306 ? -16.896 -18.659 -23.691 1.00 50.19  ? 569  PHE   A CE1 1 
ATOM   2124 C  CE2 . PHE   A 1 306 ? -18.998 -18.340 -24.752 1.00 46.62  ? 569  PHE   A CE2 1 
ATOM   2125 C  CZ  . PHE   A 1 306 ? -17.873 -19.098 -24.556 1.00 49.29  ? 569  PHE   A CZ  1 
ATOM   2126 N  N   . LYS   A 1 307 ? -18.622 -13.328 -20.085 0.50 54.57  ? 570  LYS   A N   1 
ATOM   2127 C  CA  . LYS   A 1 307 ? -18.130 -12.119 -19.361 0.50 52.20  ? 570  LYS   A CA  1 
ATOM   2128 C  C   . LYS   A 1 307 ? -18.305 -12.302 -17.846 0.50 47.92  ? 570  LYS   A C   1 
ATOM   2129 O  O   . LYS   A 1 307 ? -17.325 -12.111 -17.111 0.50 47.96  ? 570  LYS   A O   1 
ATOM   2130 C  CB  . LYS   A 1 307 ? -18.889 -10.879 -19.857 0.50 52.91  ? 570  LYS   A CB  1 
ATOM   2131 C  CG  . LYS   A 1 307 ? -18.574 -9.566  -19.146 0.50 53.69  ? 570  LYS   A CG  1 
ATOM   2132 C  CD  . LYS   A 1 307 ? -19.774 -8.625  -19.027 0.50 54.33  ? 570  LYS   A CD  1 
ATOM   2133 C  CE  . LYS   A 1 307 ? -20.487 -8.367  -20.341 0.50 52.41  ? 570  LYS   A CE  1 
ATOM   2134 N  NZ  . LYS   A 1 307 ? -21.959 -8.472  -20.204 0.50 50.19  ? 570  LYS   A NZ  1 
ATOM   2135 N  N   . LEU   A 1 308 ? -19.503 -12.684 -17.407 1.00 46.11  ? 571  LEU   A N   1 
ATOM   2136 C  CA  . LEU   A 1 308 ? -19.898 -12.606 -15.975 1.00 49.68  ? 571  LEU   A CA  1 
ATOM   2137 C  C   . LEU   A 1 308 ? -19.630 -13.855 -15.124 1.00 51.32  ? 571  LEU   A C   1 
ATOM   2138 O  O   . LEU   A 1 308 ? -19.432 -13.697 -13.906 1.00 58.27  ? 571  LEU   A O   1 
ATOM   2139 C  CB  . LEU   A 1 308 ? -21.384 -12.221 -15.920 1.00 53.54  ? 571  LEU   A CB  1 
ATOM   2140 C  CG  . LEU   A 1 308 ? -21.713 -10.894 -16.616 1.00 56.17  ? 571  LEU   A CG  1 
ATOM   2141 C  CD1 . LEU   A 1 308 ? -23.209 -10.684 -16.712 1.00 60.32  ? 571  LEU   A CD1 1 
ATOM   2142 C  CD2 . LEU   A 1 308 ? -21.057 -9.721  -15.904 1.00 53.42  ? 571  LEU   A CD2 1 
ATOM   2143 N  N   . THR   A 1 309 ? -19.612 -15.042 -15.741 0.50 50.22  ? 572  THR   A N   1 
ATOM   2144 C  CA  . THR   A 1 309 ? -19.553 -16.354 -15.037 0.50 50.04  ? 572  THR   A CA  1 
ATOM   2145 C  C   . THR   A 1 309 ? -18.337 -17.177 -15.489 0.50 46.30  ? 572  THR   A C   1 
ATOM   2146 O  O   . THR   A 1 309 ? -18.121 -18.237 -14.886 0.50 44.91  ? 572  THR   A O   1 
ATOM   2147 C  CB  . THR   A 1 309 ? -20.849 -17.149 -15.246 0.50 52.41  ? 572  THR   A CB  1 
ATOM   2148 O  OG1 . THR   A 1 309 ? -20.868 -17.659 -16.578 0.50 50.89  ? 572  THR   A OG1 1 
ATOM   2149 C  CG2 . THR   A 1 309 ? -22.093 -16.317 -15.017 0.50 54.83  ? 572  THR   A CG2 1 
ATOM   2150 N  N   . TYR   A 1 310 ? -17.589 -16.731 -16.507 0.50 45.71  ? 573  TYR   A N   1 
ATOM   2151 C  CA  . TYR   A 1 310 ? -16.389 -17.443 -17.035 0.50 47.22  ? 573  TYR   A CA  1 
ATOM   2152 C  C   . TYR   A 1 310 ? -15.138 -16.562 -16.886 0.50 47.32  ? 573  TYR   A C   1 
ATOM   2153 O  O   . TYR   A 1 310 ? -14.194 -16.994 -16.189 0.50 47.99  ? 573  TYR   A O   1 
ATOM   2154 C  CB  . TYR   A 1 310 ? -16.575 -17.895 -18.490 0.50 44.64  ? 573  TYR   A CB  1 
ATOM   2155 C  CG  . TYR   A 1 310 ? -17.586 -18.996 -18.718 0.50 43.10  ? 573  TYR   A CG  1 
ATOM   2156 C  CD1 . TYR   A 1 310 ? -18.268 -19.591 -17.668 0.50 40.10  ? 573  TYR   A CD1 1 
ATOM   2157 C  CD2 . TYR   A 1 310 ? -17.845 -19.462 -19.997 0.50 41.56  ? 573  TYR   A CD2 1 
ATOM   2158 C  CE1 . TYR   A 1 310 ? -19.200 -20.593 -17.886 0.50 39.98  ? 573  TYR   A CE1 1 
ATOM   2159 C  CE2 . TYR   A 1 310 ? -18.764 -20.471 -20.230 0.50 40.81  ? 573  TYR   A CE2 1 
ATOM   2160 C  CZ  . TYR   A 1 310 ? -19.444 -21.042 -19.172 0.50 40.97  ? 573  TYR   A CZ  1 
ATOM   2161 O  OH  . TYR   A 1 310 ? -20.356 -22.031 -19.409 0.50 42.64  ? 573  TYR   A OH  1 
ATOM   2162 N  N   . GLN   A 1 311 ? -15.115 -15.385 -17.525 0.50 44.21  ? 574  GLN   A N   1 
ATOM   2163 C  CA  . GLN   A 1 311 ? -13.964 -14.443 -17.476 0.50 45.33  ? 574  GLN   A CA  1 
ATOM   2164 C  C   . GLN   A 1 311 ? -13.962 -13.737 -16.115 0.50 45.93  ? 574  GLN   A C   1 
ATOM   2165 O  O   . GLN   A 1 311 ? -12.982 -13.020 -15.823 0.50 43.74  ? 574  GLN   A O   1 
ATOM   2166 C  CB  . GLN   A 1 311 ? -14.009 -13.467 -18.653 0.50 44.82  ? 574  GLN   A CB  1 
ATOM   2167 C  CG  . GLN   A 1 311 ? -13.998 -14.166 -20.005 0.50 43.91  ? 574  GLN   A CG  1 
ATOM   2168 C  CD  . GLN   A 1 311 ? -13.668 -13.220 -21.130 0.50 44.73  ? 574  GLN   A CD  1 
ATOM   2169 O  OE1 . GLN   A 1 311 ? -13.006 -12.206 -20.933 0.50 45.77  ? 574  GLN   A OE1 1 
ATOM   2170 N  NE2 . GLN   A 1 311 ? -14.113 -13.556 -22.329 0.50 46.06  ? 574  GLN   A NE2 1 
ATOM   2171 N  N   . ASN   A 1 312 ? -15.016 -13.968 -15.320 0.50 46.95  ? 575  ASN   A N   1 
ATOM   2172 C  CA  . ASN   A 1 312 ? -15.118 -13.619 -13.876 0.50 46.78  ? 575  ASN   A CA  1 
ATOM   2173 C  C   . ASN   A 1 312 ? -15.883 -14.736 -13.162 0.50 48.52  ? 575  ASN   A C   1 
ATOM   2174 O  O   . ASN   A 1 312 ? -16.877 -15.218 -13.735 0.50 48.17  ? 575  ASN   A O   1 
ATOM   2175 C  CB  . ASN   A 1 312 ? -15.833 -12.286 -13.641 0.50 46.85  ? 575  ASN   A CB  1 
ATOM   2176 C  CG  . ASN   A 1 312 ? -15.019 -11.096 -14.092 0.50 46.80  ? 575  ASN   A CG  1 
ATOM   2177 O  OD1 . ASN   A 1 312 ? -14.354 -10.461 -13.282 0.50 50.24  ? 575  ASN   A OD1 1 
ATOM   2178 N  ND2 . ASN   A 1 312 ? -15.047 -10.803 -15.381 0.50 47.66  ? 575  ASN   A ND2 1 
ATOM   2179 N  N   . LYS   A 1 313 ? -15.440 -15.120 -11.961 0.50 50.99  ? 576  LYS   A N   1 
ATOM   2180 C  CA  . LYS   A 1 313 ? -16.009 -16.253 -11.181 0.50 54.91  ? 576  LYS   A CA  1 
ATOM   2181 C  C   . LYS   A 1 313 ? -16.100 -15.865 -9.701  0.50 56.98  ? 576  LYS   A C   1 
ATOM   2182 O  O   . LYS   A 1 313 ? -15.255 -15.075 -9.250  0.50 60.63  ? 576  LYS   A O   1 
ATOM   2183 C  CB  . LYS   A 1 313 ? -15.131 -17.505 -11.289 0.50 56.13  ? 576  LYS   A CB  1 
ATOM   2184 C  CG  . LYS   A 1 313 ? -14.725 -17.935 -12.692 0.50 55.89  ? 576  LYS   A CG  1 
ATOM   2185 C  CD  . LYS   A 1 313 ? -14.009 -19.276 -12.698 0.50 56.65  ? 576  LYS   A CD  1 
ATOM   2186 C  CE  . LYS   A 1 313 ? -13.376 -19.613 -14.029 0.50 56.71  ? 576  LYS   A CE  1 
ATOM   2187 N  NZ  . LYS   A 1 313 ? -12.292 -18.664 -14.373 0.50 57.93  ? 576  LYS   A NZ  1 
ATOM   2188 N  N   . VAL   A 1 314 ? -17.074 -16.423 -8.980  1.00 54.29  ? 577  VAL   A N   1 
ATOM   2189 C  CA  . VAL   A 1 314 ? -17.217 -16.232 -7.518  1.00 56.34  ? 577  VAL   A CA  1 
ATOM   2190 C  C   . VAL   A 1 314 ? -17.533 -17.627 -7.030  1.00 54.89  ? 577  VAL   A C   1 
ATOM   2191 O  O   . VAL   A 1 314 ? -18.395 -18.278 -7.660  1.00 45.58  ? 577  VAL   A O   1 
ATOM   2192 C  CB  . VAL   A 1 314 ? -18.353 -15.257 -7.139  1.00 60.89  ? 577  VAL   A CB  1 
ATOM   2193 C  CG1 . VAL   A 1 314 ? -18.682 -15.317 -5.649  1.00 59.76  ? 577  VAL   A CG1 1 
ATOM   2194 C  CG2 . VAL   A 1 314 ? -18.051 -13.833 -7.581  1.00 54.65  ? 577  VAL   A CG2 1 
ATOM   2195 N  N   . VAL   A 1 315 ? -16.847 -18.060 -5.978  1.00 55.57  ? 578  VAL   A N   1 
ATOM   2196 C  CA  . VAL   A 1 315 ? -16.898 -19.477 -5.530  1.00 57.19  ? 578  VAL   A CA  1 
ATOM   2197 C  C   . VAL   A 1 315 ? -17.029 -19.500 -4.019  1.00 55.75  ? 578  VAL   A C   1 
ATOM   2198 O  O   . VAL   A 1 315 ? -16.401 -18.671 -3.368  1.00 59.32  ? 578  VAL   A O   1 
ATOM   2199 C  CB  . VAL   A 1 315 ? -15.637 -20.244 -5.963  1.00 61.36  ? 578  VAL   A CB  1 
ATOM   2200 C  CG1 . VAL   A 1 315 ? -15.837 -21.739 -5.782  1.00 66.43  ? 578  VAL   A CG1 1 
ATOM   2201 C  CG2 . VAL   A 1 315 ? -15.218 -19.905 -7.386  1.00 58.95  ? 578  VAL   A CG2 1 
ATOM   2202 N  N   . ARG   A 1 316 ? -17.743 -20.487 -3.513  1.00 61.66  ? 579  ARG   A N   1 
ATOM   2203 C  CA  . ARG   A 1 316 ? -17.886 -20.707 -2.069  1.00 68.35  ? 579  ARG   A CA  1 
ATOM   2204 C  C   . ARG   A 1 316 ? -17.247 -22.069 -1.770  1.00 75.49  ? 579  ARG   A C   1 
ATOM   2205 O  O   . ARG   A 1 316 ? -17.738 -23.087 -2.283  1.00 73.13  ? 579  ARG   A O   1 
ATOM   2206 C  CB  . ARG   A 1 316 ? -19.355 -20.520 -1.684  1.00 71.16  ? 579  ARG   A CB  1 
ATOM   2207 C  CG  . ARG   A 1 316 ? -20.332 -21.429 -2.401  1.00 75.23  ? 579  ARG   A CG  1 
ATOM   2208 C  CD  . ARG   A 1 316 ? -21.694 -21.364 -1.740  1.00 84.13  ? 579  ARG   A CD  1 
ATOM   2209 N  NE  . ARG   A 1 316 ? -22.235 -20.014 -1.727  1.00 92.01  ? 579  ARG   A NE  1 
ATOM   2210 C  CZ  . ARG   A 1 316 ? -23.387 -19.677 -1.165  1.00 97.87  ? 579  ARG   A CZ  1 
ATOM   2211 N  NH1 . ARG   A 1 316 ? -23.793 -18.418 -1.204  1.00 101.92 ? 579  ARG   A NH1 1 
ATOM   2212 N  NH2 . ARG   A 1 316 ? -24.125 -20.594 -0.561  1.00 96.07  ? 579  ARG   A NH2 1 
ATOM   2213 N  N   . VAL   A 1 317 ? -16.163 -22.063 -0.983  0.50 76.28  ? 580  VAL   A N   1 
ATOM   2214 C  CA  . VAL   A 1 317 ? -15.357 -23.264 -0.608  0.50 77.45  ? 580  VAL   A CA  1 
ATOM   2215 C  C   . VAL   A 1 317 ? -15.383 -23.417 0.916   0.50 80.40  ? 580  VAL   A C   1 
ATOM   2216 O  O   . VAL   A 1 317 ? -15.073 -22.429 1.605   0.50 77.52  ? 580  VAL   A O   1 
ATOM   2217 C  CB  . VAL   A 1 317 ? -13.910 -23.146 -1.124  0.50 76.16  ? 580  VAL   A CB  1 
ATOM   2218 C  CG1 . VAL   A 1 317 ? -13.225 -24.501 -1.178  0.50 75.78  ? 580  VAL   A CG1 1 
ATOM   2219 C  CG2 . VAL   A 1 317 ? -13.847 -22.463 -2.479  0.50 76.22  ? 580  VAL   A CG2 1 
ATOM   2220 N  N   . GLN   A 1 318 ? -15.725 -24.612 1.411   0.50 88.00  ? 581  GLN   A N   1 
ATOM   2221 C  CA  . GLN   A 1 318 ? -15.749 -24.947 2.862   0.50 93.58  ? 581  GLN   A CA  1 
ATOM   2222 C  C   . GLN   A 1 318 ? -14.324 -25.222 3.354   0.50 98.63  ? 581  GLN   A C   1 
ATOM   2223 O  O   . GLN   A 1 318 ? -13.612 -26.008 2.696   0.50 97.76  ? 581  GLN   A O   1 
ATOM   2224 C  CB  . GLN   A 1 318 ? -16.639 -26.160 3.129   0.50 92.81  ? 581  GLN   A CB  1 
ATOM   2225 C  CG  . GLN   A 1 318 ? -18.108 -25.802 3.273   0.50 96.75  ? 581  GLN   A CG  1 
ATOM   2226 C  CD  . GLN   A 1 318 ? -18.807 -26.683 4.278   0.50 100.06 ? 581  GLN   A CD  1 
ATOM   2227 O  OE1 . GLN   A 1 318 ? -18.367 -27.793 4.570   0.50 102.24 ? 581  GLN   A OE1 1 
ATOM   2228 N  NE2 . GLN   A 1 318 ? -19.907 -26.187 4.822   0.50 100.86 ? 581  GLN   A NE2 1 
ATOM   2229 N  N   . ARG   A 1 319 ? -13.943 -24.600 4.475   0.50 103.29 ? 582  ARG   A N   1 
ATOM   2230 C  CA  . ARG   A 1 319 ? -12.619 -24.766 5.133   0.50 106.76 ? 582  ARG   A CA  1 
ATOM   2231 C  C   . ARG   A 1 319 ? -12.839 -25.298 6.549   0.50 112.55 ? 582  ARG   A C   1 
ATOM   2232 O  O   . ARG   A 1 319 ? -13.648 -24.740 7.289   0.50 110.14 ? 582  ARG   A O   1 
ATOM   2233 C  CB  . ARG   A 1 319 ? -11.867 -23.431 5.137   0.50 105.70 ? 582  ARG   A CB  1 
ATOM   2234 C  CG  . ARG   A 1 319 ? -10.452 -23.513 5.690   0.50 105.62 ? 582  ARG   A CG  1 
ATOM   2235 C  CD  . ARG   A 1 319 ? -9.530  -22.489 5.057   0.50 107.05 ? 582  ARG   A CD  1 
ATOM   2236 N  NE  . ARG   A 1 319 ? -10.101 -21.151 5.038   0.50 108.27 ? 582  ARG   A NE  1 
ATOM   2237 C  CZ  . ARG   A 1 319 ? -9.768  -20.180 5.880   0.50 110.19 ? 582  ARG   A CZ  1 
ATOM   2238 N  NH1 . ARG   A 1 319 ? -8.859  -20.399 6.814   0.50 112.84 ? 582  ARG   A NH1 1 
ATOM   2239 N  NH2 . ARG   A 1 319 ? -10.339 -18.992 5.783   0.50 110.01 ? 582  ARG   A NH2 1 
ATOM   2240 N  N   . PRO   A 1 320 ? -12.148 -26.387 6.970   1.00 120.21 ? 583  PRO   A N   1 
ATOM   2241 C  CA  . PRO   A 1 320 ? -12.357 -26.964 8.308   1.00 120.58 ? 583  PRO   A CA  1 
ATOM   2242 C  C   . PRO   A 1 320 ? -12.184 -26.056 9.544   1.00 123.28 ? 583  PRO   A C   1 
ATOM   2243 O  O   . PRO   A 1 320 ? -12.927 -26.222 10.506  1.00 116.99 ? 583  PRO   A O   1 
ATOM   2244 C  CB  . PRO   A 1 320 ? -11.273 -28.059 8.402   1.00 122.89 ? 583  PRO   A CB  1 
ATOM   2245 C  CG  . PRO   A 1 320 ? -10.904 -28.399 6.969   1.00 119.24 ? 583  PRO   A CG  1 
ATOM   2246 C  CD  . PRO   A 1 320 ? -11.132 -27.123 6.186   1.00 123.63 ? 583  PRO   A CD  1 
ATOM   2247 N  N   . THR   A 1 321 ? -11.222 -25.130 9.493   1.00 118.02 ? 584  THR   A N   1 
ATOM   2248 C  CA  . THR   A 1 321 ? -10.778 -24.283 10.635  1.00 115.62 ? 584  THR   A CA  1 
ATOM   2249 C  C   . THR   A 1 321 ? -11.981 -23.576 11.271  1.00 104.44 ? 584  THR   A C   1 
ATOM   2250 O  O   . THR   A 1 321 ? -11.918 -23.360 12.494  1.00 105.72 ? 584  THR   A O   1 
ATOM   2251 C  CB  . THR   A 1 321 ? -9.723  -23.275 10.169  1.00 121.86 ? 584  THR   A CB  1 
ATOM   2252 O  OG1 . THR   A 1 321 ? -10.330 -22.506 9.132   1.00 119.79 ? 584  THR   A OG1 1 
ATOM   2253 C  CG2 . THR   A 1 321 ? -8.455  -23.927 9.659   1.00 121.97 ? 584  THR   A CG2 1 
ATOM   2254 N  N   . THR   A 1 325 ? -15.801 -25.084 10.892  0.50 111.59 ? 588  THR   A N   1 
ATOM   2255 C  CA  . THR   A 1 325 ? -15.933 -25.045 9.411   0.50 110.92 ? 588  THR   A CA  1 
ATOM   2256 C  C   . THR   A 1 325 ? -16.623 -23.743 8.990   0.50 110.17 ? 588  THR   A C   1 
ATOM   2257 O  O   . THR   A 1 325 ? -17.800 -23.548 9.363   0.50 107.81 ? 588  THR   A O   1 
ATOM   2258 C  CB  . THR   A 1 325 ? -16.705 -26.260 8.883   0.50 112.73 ? 588  THR   A CB  1 
ATOM   2259 O  OG1 . THR   A 1 325 ? -15.846 -27.399 8.939   0.50 113.25 ? 588  THR   A OG1 1 
ATOM   2260 C  CG2 . THR   A 1 325 ? -17.195 -26.067 7.465   0.50 114.64 ? 588  THR   A CG2 1 
ATOM   2261 N  N   . VAL   A 1 326 ? -15.912 -22.897 8.237   0.50 106.75 ? 589  VAL   A N   1 
ATOM   2262 C  CA  . VAL   A 1 326 ? -16.432 -21.613 7.680   0.50 103.34 ? 589  VAL   A CA  1 
ATOM   2263 C  C   . VAL   A 1 326 ? -16.746 -21.814 6.193   0.50 96.83  ? 589  VAL   A C   1 
ATOM   2264 O  O   . VAL   A 1 326 ? -16.437 -22.901 5.657   0.50 91.02  ? 589  VAL   A O   1 
ATOM   2265 C  CB  . VAL   A 1 326 ? -15.428 -20.460 7.880   0.50 105.64 ? 589  VAL   A CB  1 
ATOM   2266 C  CG1 . VAL   A 1 326 ? -14.820 -20.474 9.274   0.50 107.90 ? 589  VAL   A CG1 1 
ATOM   2267 C  CG2 . VAL   A 1 326 ? -14.335 -20.470 6.821   0.50 106.70 ? 589  VAL   A CG2 1 
ATOM   2268 N  N   . MET   A 1 327 ? -17.351 -20.799 5.569   0.50 91.52  ? 590  MET   A N   1 
ATOM   2269 C  CA  . MET   A 1 327 ? -17.536 -20.688 4.098   0.50 87.68  ? 590  MET   A CA  1 
ATOM   2270 C  C   . MET   A 1 327 ? -16.683 -19.517 3.597   0.50 79.27  ? 590  MET   A C   1 
ATOM   2271 O  O   . MET   A 1 327 ? -16.802 -18.416 4.163   0.50 76.99  ? 590  MET   A O   1 
ATOM   2272 C  CB  . MET   A 1 327 ? -19.005 -20.449 3.735   0.50 88.70  ? 590  MET   A CB  1 
ATOM   2273 C  CG  . MET   A 1 327 ? -19.306 -20.677 2.267   0.50 89.39  ? 590  MET   A CG  1 
ATOM   2274 S  SD  . MET   A 1 327 ? -18.931 -22.369 1.735   0.50 88.27  ? 590  MET   A SD  1 
ATOM   2275 C  CE  . MET   A 1 327 ? -20.245 -23.276 2.551   0.50 86.77  ? 590  MET   A CE  1 
ATOM   2276 N  N   . ASP   A 1 328 ? -15.840 -19.764 2.592   0.50 74.57  ? 591  ASP   A N   1 
ATOM   2277 C  CA  . ASP   A 1 328 ? -14.864 -18.781 2.051   0.50 72.76  ? 591  ASP   A CA  1 
ATOM   2278 C  C   . ASP   A 1 328 ? -15.330 -18.352 0.654   0.50 71.49  ? 591  ASP   A C   1 
ATOM   2279 O  O   . ASP   A 1 328 ? -15.509 -19.238 -0.204  0.50 72.48  ? 591  ASP   A O   1 
ATOM   2280 C  CB  . ASP   A 1 328 ? -13.449 -19.368 2.056   0.50 71.52  ? 591  ASP   A CB  1 
ATOM   2281 C  CG  . ASP   A 1 328 ? -12.995 -19.846 3.429   0.50 69.50  ? 591  ASP   A CG  1 
ATOM   2282 O  OD1 . ASP   A 1 328 ? -13.026 -19.029 4.375   0.50 69.73  ? 591  ASP   A OD1 1 
ATOM   2283 O  OD2 . ASP   A 1 328 ? -12.627 -21.033 3.547   0.50 61.40  ? 591  ASP   A OD2 1 
ATOM   2284 N  N   . ILE   A 1 329 ? -15.513 -17.043 0.452   1.00 67.29  ? 592  ILE   A N   1 
ATOM   2285 C  CA  . ILE   A 1 329 ? -16.081 -16.463 -0.787  1.00 63.72  ? 592  ILE   A CA  1 
ATOM   2286 C  C   . ILE   A 1 329 ? -14.887 -15.908 -1.531  1.00 66.02  ? 592  ILE   A C   1 
ATOM   2287 O  O   . ILE   A 1 329 ? -14.362 -14.855 -1.142  1.00 57.31  ? 592  ILE   A O   1 
ATOM   2288 C  CB  . ILE   A 1 329 ? -17.144 -15.392 -0.475  1.00 62.72  ? 592  ILE   A CB  1 
ATOM   2289 C  CG1 . ILE   A 1 329 ? -18.360 -16.007 0.225   1.00 64.38  ? 592  ILE   A CG1 1 
ATOM   2290 C  CG2 . ILE   A 1 329 ? -17.531 -14.616 -1.723  1.00 61.51  ? 592  ILE   A CG2 1 
ATOM   2291 C  CD1 . ILE   A 1 329 ? -18.847 -17.308 -0.370  1.00 62.94  ? 592  ILE   A CD1 1 
ATOM   2292 N  N   . ILE   A 1 330 ? -14.458 -16.648 -2.539  1.00 75.35  ? 593  ILE   A N   1 
ATOM   2293 C  CA  . ILE   A 1 330 ? -13.203 -16.345 -3.272  1.00 79.46  ? 593  ILE   A CA  1 
ATOM   2294 C  C   . ILE   A 1 330 ? -13.573 -16.108 -4.731  1.00 68.07  ? 593  ILE   A C   1 
ATOM   2295 O  O   . ILE   A 1 330 ? -14.682 -16.498 -5.128  1.00 68.05  ? 593  ILE   A O   1 
ATOM   2296 C  CB  . ILE   A 1 330 ? -12.191 -17.489 -3.075  1.00 89.06  ? 593  ILE   A CB  1 
ATOM   2297 C  CG1 . ILE   A 1 330 ? -12.860 -18.866 -3.192  1.00 86.92  ? 593  ILE   A CG1 1 
ATOM   2298 C  CG2 . ILE   A 1 330 ? -11.471 -17.316 -1.746  1.00 90.37  ? 593  ILE   A CG2 1 
ATOM   2299 C  CD1 . ILE   A 1 330 ? -11.909 -20.002 -3.508  1.00 82.84  ? 593  ILE   A CD1 1 
ATOM   2300 N  N   . SER   A 1 331 ? -12.658 -15.507 -5.480  1.00 64.36  ? 594  SER   A N   1 
ATOM   2301 C  CA  . SER   A 1 331 ? -12.865 -15.145 -6.895  1.00 59.58  ? 594  SER   A CA  1 
ATOM   2302 C  C   . SER   A 1 331 ? -11.545 -15.200 -7.666  1.00 62.52  ? 594  SER   A C   1 
ATOM   2303 O  O   . SER   A 1 331 ? -10.463 -15.151 -7.057  1.00 62.92  ? 594  SER   A O   1 
ATOM   2304 C  CB  . SER   A 1 331 ? -13.457 -13.792 -6.954  1.00 56.23  ? 594  SER   A CB  1 
ATOM   2305 O  OG  . SER   A 1 331 ? -12.477 -12.855 -6.566  1.00 58.98  ? 594  SER   A OG  1 
ATOM   2306 N  N   . ARG   A 1 332 ? -11.640 -15.292 -8.995  0.50 61.01  ? 595  ARG   A N   1 
ATOM   2307 C  CA  . ARG   A 1 332 ? -10.497 -15.195 -9.940  0.50 60.38  ? 595  ARG   A CA  1 
ATOM   2308 C  C   . ARG   A 1 332 ? -11.053 -15.166 -11.362 0.50 61.41  ? 595  ARG   A C   1 
ATOM   2309 O  O   . ARG   A 1 332 ? -12.260 -15.429 -11.524 0.50 66.61  ? 595  ARG   A O   1 
ATOM   2310 C  CB  . ARG   A 1 332 ? -9.524  -16.369 -9.792  0.50 60.87  ? 595  ARG   A CB  1 
ATOM   2311 C  CG  . ARG   A 1 332 ? -9.911  -17.606 -10.587 0.50 58.75  ? 595  ARG   A CG  1 
ATOM   2312 C  CD  . ARG   A 1 332 ? -8.881  -18.706 -10.425 0.50 58.39  ? 595  ARG   A CD  1 
ATOM   2313 N  NE  . ARG   A 1 332 ? -7.583  -18.354 -10.986 0.50 56.97  ? 595  ARG   A NE  1 
ATOM   2314 C  CZ  . ARG   A 1 332 ? -6.424  -18.866 -10.579 0.50 55.87  ? 595  ARG   A CZ  1 
ATOM   2315 N  NH1 . ARG   A 1 332 ? -6.398  -19.747 -9.593  0.50 54.41  ? 595  ARG   A NH1 1 
ATOM   2316 N  NH2 . ARG   A 1 332 ? -5.295  -18.493 -11.152 0.50 55.84  ? 595  ARG   A NH2 1 
ATOM   2317 N  N   . ARG   A 1 333 ? -10.195 -14.886 -12.343 0.50 60.50  ? 596  ARG   A N   1 
ATOM   2318 C  CA  . ARG   A 1 333 ? -10.596 -14.653 -13.753 0.50 63.13  ? 596  ARG   A CA  1 
ATOM   2319 C  C   . ARG   A 1 333 ? -10.379 -15.931 -14.579 0.50 60.71  ? 596  ARG   A C   1 
ATOM   2320 O  O   . ARG   A 1 333 ? -11.387 -16.481 -15.078 0.50 56.40  ? 596  ARG   A O   1 
ATOM   2321 C  CB  . ARG   A 1 333 ? -9.830  -13.442 -14.290 0.50 65.55  ? 596  ARG   A CB  1 
ATOM   2322 C  CG  . ARG   A 1 333 ? -9.945  -12.214 -13.395 0.50 72.23  ? 596  ARG   A CG  1 
ATOM   2323 C  CD  . ARG   A 1 333 ? -9.800  -10.915 -14.167 0.50 77.38  ? 596  ARG   A CD  1 
ATOM   2324 N  NE  . ARG   A 1 333 ? -10.703 -10.879 -15.311 0.50 84.17  ? 596  ARG   A NE  1 
ATOM   2325 C  CZ  . ARG   A 1 333 ? -10.474 -10.206 -16.435 0.50 86.60  ? 596  ARG   A CZ  1 
ATOM   2326 N  NH1 . ARG   A 1 333 ? -9.361  -9.505  -16.573 0.50 86.60  ? 596  ARG   A NH1 1 
ATOM   2327 N  NH2 . ARG   A 1 333 ? -11.357 -10.244 -17.418 0.50 87.01  ? 596  ARG   A NH2 1 
ATOM   2328 N  N   . ASP   A 1 334 ? -9.127  -16.387 -14.707 0.50 55.62  ? 597  ASP   A N   1 
ATOM   2329 C  CA  . ASP   A 1 334 ? -8.725  -17.517 -15.591 0.50 53.20  ? 597  ASP   A CA  1 
ATOM   2330 C  C   . ASP   A 1 334 ? -9.082  -18.855 -14.921 0.50 51.46  ? 597  ASP   A C   1 
ATOM   2331 O  O   . ASP   A 1 334 ? -9.620  -18.826 -13.798 0.50 48.61  ? 597  ASP   A O   1 
ATOM   2332 C  CB  . ASP   A 1 334 ? -7.244  -17.414 -15.975 0.50 51.61  ? 597  ASP   A CB  1 
ATOM   2333 C  CG  . ASP   A 1 334 ? -6.274  -17.783 -14.865 0.50 50.04  ? 597  ASP   A CG  1 
ATOM   2334 O  OD1 . ASP   A 1 334 ? -6.747  -18.128 -13.763 0.50 52.38  ? 597  ASP   A OD1 1 
ATOM   2335 O  OD2 . ASP   A 1 334 ? -5.053  -17.738 -15.117 0.50 47.95  ? 597  ASP   A OD2 1 
ATOM   2336 N  N   . GLN   A 1 335 ? -8.806  -19.971 -15.613 0.50 51.16  ? 598  GLN   A N   1 
ATOM   2337 C  CA  . GLN   A 1 335 ? -9.140  -21.372 -15.218 0.50 49.24  ? 598  GLN   A CA  1 
ATOM   2338 C  C   . GLN   A 1 335 ? -10.534 -21.749 -15.738 0.50 48.10  ? 598  GLN   A C   1 
ATOM   2339 O  O   . GLN   A 1 335 ? -11.359 -20.833 -15.954 0.50 47.75  ? 598  GLN   A O   1 
ATOM   2340 C  CB  . GLN   A 1 335 ? -9.079  -21.567 -13.700 0.50 50.66  ? 598  GLN   A CB  1 
ATOM   2341 C  CG  . GLN   A 1 335 ? -7.662  -21.730 -13.161 0.50 50.90  ? 598  GLN   A CG  1 
ATOM   2342 C  CD  . GLN   A 1 335 ? -7.616  -22.503 -11.864 0.50 51.86  ? 598  GLN   A CD  1 
ATOM   2343 O  OE1 . GLN   A 1 335 ? -8.484  -23.324 -11.571 0.50 52.54  ? 598  GLN   A OE1 1 
ATOM   2344 N  NE2 . GLN   A 1 335 ? -6.584  -22.251 -11.076 0.50 51.49  ? 598  GLN   A NE2 1 
ATOM   2345 N  N   . ARG   A 1 336 ? -10.775 -23.054 -15.911 0.50 45.63  ? 599  ARG   A N   1 
ATOM   2346 C  CA  . ARG   A 1 336 ? -12.073 -23.638 -16.342 0.50 46.57  ? 599  ARG   A CA  1 
ATOM   2347 C  C   . ARG   A 1 336 ? -13.035 -23.739 -15.154 0.50 47.29  ? 599  ARG   A C   1 
ATOM   2348 O  O   . ARG   A 1 336 ? -12.757 -24.515 -14.212 0.50 47.90  ? 599  ARG   A O   1 
ATOM   2349 C  CB  . ARG   A 1 336 ? -11.887 -25.034 -16.942 0.50 44.53  ? 599  ARG   A CB  1 
ATOM   2350 C  CG  . ARG   A 1 336 ? -13.188 -25.674 -17.402 0.50 41.08  ? 599  ARG   A CG  1 
ATOM   2351 C  CD  . ARG   A 1 336 ? -13.762 -24.927 -18.582 0.50 39.54  ? 599  ARG   A CD  1 
ATOM   2352 N  NE  . ARG   A 1 336 ? -12.969 -25.190 -19.764 0.50 37.95  ? 599  ARG   A NE  1 
ATOM   2353 C  CZ  . ARG   A 1 336 ? -12.792 -24.335 -20.754 0.50 37.24  ? 599  ARG   A CZ  1 
ATOM   2354 N  NH1 . ARG   A 1 336 ? -13.362 -23.144 -20.704 0.50 36.55  ? 599  ARG   A NH1 1 
ATOM   2355 N  NH2 . ARG   A 1 336 ? -12.049 -24.680 -21.791 0.50 36.76  ? 599  ARG   A NH2 1 
ATOM   2356 N  N   . GLY   A 1 337 ? -14.129 -22.978 -15.224 0.50 49.06  ? 600  GLY   A N   1 
ATOM   2357 C  CA  . GLY   A 1 337 ? -15.290 -23.052 -14.321 0.50 50.70  ? 600  GLY   A CA  1 
ATOM   2358 C  C   . GLY   A 1 337 ? -16.572 -22.896 -15.119 0.50 52.99  ? 600  GLY   A C   1 
ATOM   2359 O  O   . GLY   A 1 337 ? -16.898 -21.752 -15.486 0.50 55.73  ? 600  GLY   A O   1 
ATOM   2360 N  N   . SER   A 1 338 ? -17.229 -24.021 -15.416 0.50 52.93  ? 601  SER   A N   1 
ATOM   2361 C  CA  . SER   A 1 338 ? -18.460 -24.145 -16.239 0.50 51.54  ? 601  SER   A CA  1 
ATOM   2362 C  C   . SER   A 1 338 ? -19.130 -25.486 -15.918 0.50 51.85  ? 601  SER   A C   1 
ATOM   2363 O  O   . SER   A 1 338 ? -18.459 -26.358 -15.332 0.50 48.52  ? 601  SER   A O   1 
ATOM   2364 C  CB  . SER   A 1 338 ? -18.148 -24.051 -17.717 0.50 52.50  ? 601  SER   A CB  1 
ATOM   2365 O  OG  . SER   A 1 338 ? -17.151 -23.075 -17.974 0.50 55.16  ? 601  SER   A OG  1 
ATOM   2366 N  N   . GLY   A 1 339 ? -20.397 -25.651 -16.302 0.50 53.76  ? 602  GLY   A N   1 
ATOM   2367 C  CA  . GLY   A 1 339 ? -21.060 -26.968 -16.321 0.50 54.86  ? 602  GLY   A CA  1 
ATOM   2368 C  C   . GLY   A 1 339 ? -20.130 -28.008 -16.915 0.50 53.41  ? 602  GLY   A C   1 
ATOM   2369 O  O   . GLY   A 1 339 ? -19.240 -27.615 -17.688 0.50 49.65  ? 602  GLY   A O   1 
ATOM   2370 N  N   . GLN   A 1 340 ? -20.318 -29.283 -16.564 0.50 54.82  ? 603  GLN   A N   1 
ATOM   2371 C  CA  . GLN   A 1 340 ? -19.426 -30.393 -16.988 0.50 57.80  ? 603  GLN   A CA  1 
ATOM   2372 C  C   . GLN   A 1 340 ? -19.602 -30.655 -18.493 0.50 55.51  ? 603  GLN   A C   1 
ATOM   2373 O  O   . GLN   A 1 340 ? -18.634 -31.131 -19.110 0.50 57.06  ? 603  GLN   A O   1 
ATOM   2374 C  CB  . GLN   A 1 340 ? -19.673 -31.636 -16.123 0.50 62.49  ? 603  GLN   A CB  1 
ATOM   2375 C  CG  . GLN   A 1 340 ? -21.143 -32.000 -15.954 0.50 66.86  ? 603  GLN   A CG  1 
ATOM   2376 C  CD  . GLN   A 1 340 ? -21.354 -33.092 -14.931 0.50 69.04  ? 603  GLN   A CD  1 
ATOM   2377 O  OE1 . GLN   A 1 340 ? -22.482 -33.475 -14.617 0.50 71.34  ? 603  GLN   A OE1 1 
ATOM   2378 N  NE2 . GLN   A 1 340 ? -20.257 -33.608 -14.402 0.50 66.99  ? 603  GLN   A NE2 1 
ATOM   2379 N  N   . VAL   A 1 341 ? -20.774 -30.348 -19.066 1.00 54.62  ? 604  VAL   A N   1 
ATOM   2380 C  CA  . VAL   A 1 341 ? -21.060 -30.576 -20.525 1.00 47.65  ? 604  VAL   A CA  1 
ATOM   2381 C  C   . VAL   A 1 341 ? -20.503 -29.456 -21.411 1.00 43.63  ? 604  VAL   A C   1 
ATOM   2382 O  O   . VAL   A 1 341 ? -19.937 -29.760 -22.519 1.00 38.04  ? 604  VAL   A O   1 
ATOM   2383 C  CB  . VAL   A 1 341 ? -22.553 -30.802 -20.819 1.00 49.55  ? 604  VAL   A CB  1 
ATOM   2384 C  CG1 . VAL   A 1 341 ? -22.761 -30.963 -22.318 1.00 56.10  ? 604  VAL   A CG1 1 
ATOM   2385 C  CG2 . VAL   A 1 341 ? -23.114 -32.008 -20.066 1.00 47.43  ? 604  VAL   A CG2 1 
ATOM   2386 N  N   . VAL   A 1 342 ? -20.688 -28.201 -20.988 0.50 40.36  ? 605  VAL   A N   1 
ATOM   2387 C  CA  . VAL   A 1 342 ? -20.110 -27.017 -21.687 0.50 38.49  ? 605  VAL   A CA  1 
ATOM   2388 C  C   . VAL   A 1 342 ? -18.584 -27.126 -21.618 0.50 34.94  ? 605  VAL   A C   1 
ATOM   2389 O  O   . VAL   A 1 342 ? -17.937 -26.943 -22.663 0.50 35.12  ? 605  VAL   A O   1 
ATOM   2390 C  CB  . VAL   A 1 342 ? -20.639 -25.695 -21.102 0.50 39.30  ? 605  VAL   A CB  1 
ATOM   2391 C  CG1 . VAL   A 1 342 ? -19.722 -24.522 -21.398 0.50 39.77  ? 605  VAL   A CG1 1 
ATOM   2392 C  CG2 . VAL   A 1 342 ? -22.044 -25.407 -21.606 0.50 41.77  ? 605  VAL   A CG2 1 
ATOM   2393 N  N   . THR   A 1 343 ? -18.042 -27.446 -20.440 0.50 32.37  ? 606  THR   A N   1 
ATOM   2394 C  CA  . THR   A 1 343 ? -16.585 -27.633 -20.199 0.50 32.52  ? 606  THR   A CA  1 
ATOM   2395 C  C   . THR   A 1 343 ? -16.016 -28.678 -21.172 0.50 31.73  ? 606  THR   A C   1 
ATOM   2396 O  O   . THR   A 1 343 ? -14.896 -28.459 -21.664 0.50 32.44  ? 606  THR   A O   1 
ATOM   2397 C  CB  . THR   A 1 343 ? -16.306 -28.014 -18.739 0.50 31.53  ? 606  THR   A CB  1 
ATOM   2398 O  OG1 . THR   A 1 343 ? -16.368 -26.825 -17.954 0.50 30.27  ? 606  THR   A OG1 1 
ATOM   2399 C  CG2 . THR   A 1 343 ? -14.949 -28.654 -18.549 0.50 31.51  ? 606  THR   A CG2 1 
ATOM   2400 N  N   . TYR   A 1 344 ? -16.747 -29.769 -21.440 1.00 31.63  ? 607  TYR   A N   1 
ATOM   2401 C  CA  . TYR   A 1 344 ? -16.309 -30.783 -22.414 1.00 28.85  ? 607  TYR   A CA  1 
ATOM   2402 C  C   . TYR   A 1 344 ? -16.111 -30.121 -23.776 1.00 30.34  ? 607  TYR   A C   1 
ATOM   2403 O  O   . TYR   A 1 344 ? -15.058 -30.336 -24.426 1.00 29.39  ? 607  TYR   A O   1 
ATOM   2404 C  CB  . TYR   A 1 344 ? -17.304 -31.935 -22.505 1.00 29.04  ? 607  TYR   A CB  1 
ATOM   2405 C  CG  . TYR   A 1 344 ? -16.932 -32.954 -23.553 1.00 30.38  ? 607  TYR   A CG  1 
ATOM   2406 C  CD1 . TYR   A 1 344 ? -16.016 -33.955 -23.268 1.00 30.35  ? 607  TYR   A CD1 1 
ATOM   2407 C  CD2 . TYR   A 1 344 ? -17.432 -32.887 -24.845 1.00 29.96  ? 607  TYR   A CD2 1 
ATOM   2408 C  CE1 . TYR   A 1 344 ? -15.621 -34.877 -24.228 1.00 30.96  ? 607  TYR   A CE1 1 
ATOM   2409 C  CE2 . TYR   A 1 344 ? -17.067 -33.817 -25.809 1.00 33.88  ? 607  TYR   A CE2 1 
ATOM   2410 C  CZ  . TYR   A 1 344 ? -16.158 -34.820 -25.502 1.00 33.61  ? 607  TYR   A CZ  1 
ATOM   2411 O  OH  . TYR   A 1 344 ? -15.771 -35.740 -26.436 1.00 35.43  ? 607  TYR   A OH  1 
ATOM   2412 N  N   . GLY   A 1 345 ? -17.103 -29.347 -24.226 1.00 28.61  ? 608  GLY   A N   1 
ATOM   2413 C  CA  . GLY   A 1 345 ? -17.070 -28.791 -25.592 1.00 28.57  ? 608  GLY   A CA  1 
ATOM   2414 C  C   . GLY   A 1 345 ? -15.980 -27.757 -25.749 1.00 28.47  ? 608  GLY   A C   1 
ATOM   2415 O  O   . GLY   A 1 345 ? -15.375 -27.711 -26.820 1.00 30.93  ? 608  GLY   A O   1 
ATOM   2416 N  N   . LEU   A 1 346 ? -15.780 -26.922 -24.733 1.00 26.81  ? 609  LEU   A N   1 
ATOM   2417 C  CA  . LEU   A 1 346 ? -14.819 -25.805 -24.805 1.00 31.58  ? 609  LEU   A CA  1 
ATOM   2418 C  C   . LEU   A 1 346 ? -13.405 -26.382 -24.606 1.00 31.06  ? 609  LEU   A C   1 
ATOM   2419 O  O   . LEU   A 1 346 ? -12.462 -25.872 -25.267 1.00 30.21  ? 609  LEU   A O   1 
ATOM   2420 C  CB  . LEU   A 1 346 ? -15.178 -24.724 -23.765 1.00 30.37  ? 609  LEU   A CB  1 
ATOM   2421 C  CG  . LEU   A 1 346 ? -16.439 -23.906 -24.037 1.00 30.62  ? 609  LEU   A CG  1 
ATOM   2422 C  CD1 . LEU   A 1 346 ? -16.594 -22.799 -23.002 1.00 31.51  ? 609  LEU   A CD1 1 
ATOM   2423 C  CD2 . LEU   A 1 346 ? -16.450 -23.299 -25.422 1.00 31.24  ? 609  LEU   A CD2 1 
ATOM   2424 N  N   . ASN   A 1 347 ? -13.271 -27.428 -23.776 1.00 28.74  ? 610  ASN   A N   1 
ATOM   2425 C  CA  . ASN   A 1 347 ? -12.000 -28.186 -23.653 1.00 29.45  ? 610  ASN   A CA  1 
ATOM   2426 C  C   . ASN   A 1 347 ? -11.642 -28.762 -25.020 1.00 26.65  ? 610  ASN   A C   1 
ATOM   2427 O  O   . ASN   A 1 347 ? -10.549 -28.513 -25.462 1.00 26.71  ? 610  ASN   A O   1 
ATOM   2428 C  CB  . ASN   A 1 347 ? -12.048 -29.252 -22.564 1.00 27.79  ? 610  ASN   A CB  1 
ATOM   2429 C  CG  . ASN   A 1 347 ? -11.886 -28.646 -21.197 1.00 29.29  ? 610  ASN   A CG  1 
ATOM   2430 O  OD1 . ASN   A 1 347 ? -11.528 -27.481 -21.043 1.00 28.77  ? 610  ASN   A OD1 1 
ATOM   2431 N  ND2 . ASN   A 1 347 ? -12.143 -29.440 -20.180 1.00 33.83  ? 610  ASN   A ND2 1 
ATOM   2432 N  N   . THR   A 1 348 ? -12.576 -29.409 -25.705 1.00 29.15  ? 611  THR   A N   1 
ATOM   2433 C  CA  . THR   A 1 348 ? -12.347 -29.995 -27.049 1.00 28.84  ? 611  THR   A CA  1 
ATOM   2434 C  C   . THR   A 1 348 ? -11.865 -28.895 -28.003 1.00 30.13  ? 611  THR   A C   1 
ATOM   2435 O  O   . THR   A 1 348 ? -10.867 -29.121 -28.743 1.00 28.76  ? 611  THR   A O   1 
ATOM   2436 C  CB  . THR   A 1 348 ? -13.602 -30.692 -27.566 1.00 27.28  ? 611  THR   A CB  1 
ATOM   2437 O  OG1 . THR   A 1 348 ? -14.030 -31.620 -26.577 1.00 28.37  ? 611  THR   A OG1 1 
ATOM   2438 C  CG2 . THR   A 1 348 ? -13.373 -31.396 -28.873 1.00 25.79  ? 611  THR   A CG2 1 
ATOM   2439 N  N   . PHE   A 1 349 ? -12.572 -27.764 -28.015 1.00 32.52  ? 612  PHE   A N   1 
ATOM   2440 C  CA  . PHE   A 1 349 ? -12.272 -26.625 -28.918 1.00 31.99  ? 612  PHE   A CA  1 
ATOM   2441 C  C   . PHE   A 1 349 ? -10.826 -26.150 -28.677 1.00 31.64  ? 612  PHE   A C   1 
ATOM   2442 O  O   . PHE   A 1 349 ? -10.077 -26.029 -29.632 1.00 27.91  ? 612  PHE   A O   1 
ATOM   2443 C  CB  . PHE   A 1 349 ? -13.246 -25.478 -28.674 1.00 32.59  ? 612  PHE   A CB  1 
ATOM   2444 C  CG  . PHE   A 1 349 ? -12.954 -24.286 -29.541 1.00 31.45  ? 612  PHE   A CG  1 
ATOM   2445 C  CD1 . PHE   A 1 349 ? -13.463 -24.216 -30.822 1.00 34.37  ? 612  PHE   A CD1 1 
ATOM   2446 C  CD2 . PHE   A 1 349 ? -12.156 -23.263 -29.089 1.00 29.05  ? 612  PHE   A CD2 1 
ATOM   2447 C  CE1 . PHE   A 1 349 ? -13.188 -23.139 -31.645 1.00 34.18  ? 612  PHE   A CE1 1 
ATOM   2448 C  CE2 . PHE   A 1 349 ? -11.892 -22.179 -29.908 1.00 32.59  ? 612  PHE   A CE2 1 
ATOM   2449 C  CZ  . PHE   A 1 349 ? -12.387 -22.122 -31.187 1.00 31.82  ? 612  PHE   A CZ  1 
ATOM   2450 N  N   . THR   A 1 350 ? -10.489 -25.825 -27.432 1.00 29.55  ? 613  THR   A N   1 
ATOM   2451 C  CA  . THR   A 1 350 ? -9.198  -25.205 -27.066 1.00 38.42  ? 613  THR   A CA  1 
ATOM   2452 C  C   . THR   A 1 350 ? -8.085  -26.244 -27.292 1.00 35.37  ? 613  THR   A C   1 
ATOM   2453 O  O   . THR   A 1 350 ? -7.022  -25.848 -27.804 1.00 38.32  ? 613  THR   A O   1 
ATOM   2454 C  CB  . THR   A 1 350 ? -9.259  -24.618 -25.657 1.00 37.00  ? 613  THR   A CB  1 
ATOM   2455 O  OG1 . THR   A 1 350 ? -10.201 -23.556 -25.706 1.00 34.84  ? 613  THR   A OG1 1 
ATOM   2456 C  CG2 . THR   A 1 350 ? -7.917  -24.091 -25.195 1.00 38.63  ? 613  THR   A CG2 1 
ATOM   2457 N  N   . ASN   A 1 351 ? -8.383  -27.532 -27.070 1.00 30.99  ? 614  ASN   A N   1 
ATOM   2458 C  CA  . ASN   A 1 351 ? -7.433  -28.643 -27.323 1.00 31.93  ? 614  ASN   A CA  1 
ATOM   2459 C  C   . ASN   A 1 351 ? -7.211  -28.783 -28.835 1.00 30.42  ? 614  ASN   A C   1 
ATOM   2460 O  O   . ASN   A 1 351 ? -6.059  -28.932 -29.239 1.00 29.61  ? 614  ASN   A O   1 
ATOM   2461 C  CB  . ASN   A 1 351 ? -7.864  -29.959 -26.658 1.00 29.49  ? 614  ASN   A CB  1 
ATOM   2462 C  CG  . ASN   A 1 351 ? -6.697  -30.904 -26.381 1.00 30.51  ? 614  ASN   A CG  1 
ATOM   2463 O  OD1 . ASN   A 1 351 ? -5.516  -30.535 -26.547 1.00 29.43  ? 614  ASN   A OD1 1 
ATOM   2464 N  ND2 . ASN   A 1 351 ? -7.019  -32.108 -25.918 1.00 29.12  ? 614  ASN   A ND2 1 
ATOM   2465 N  N   . MET   A 1 352 ? -8.262  -28.700 -29.639 1.00 27.16  ? 615  MET   A N   1 
ATOM   2466 C  CA  . MET   A 1 352 ? -8.139  -28.747 -31.115 1.00 32.23  ? 615  MET   A CA  1 
ATOM   2467 C  C   . MET   A 1 352 ? -7.213  -27.598 -31.562 1.00 33.25  ? 615  MET   A C   1 
ATOM   2468 O  O   . MET   A 1 352 ? -6.314  -27.834 -32.398 1.00 31.17  ? 615  MET   A O   1 
ATOM   2469 C  CB  . MET   A 1 352 ? -9.500  -28.617 -31.819 1.00 29.68  ? 615  MET   A CB  1 
ATOM   2470 C  CG  . MET   A 1 352 ? -10.370 -29.836 -31.696 1.00 31.04  ? 615  MET   A CG  1 
ATOM   2471 S  SD  . MET   A 1 352 ? -12.044 -29.656 -32.414 1.00 34.84  ? 615  MET   A SD  1 
ATOM   2472 C  CE  . MET   A 1 352 ? -11.654 -29.292 -34.117 1.00 32.31  ? 615  MET   A CE  1 
ATOM   2473 N  N   . GLU   A 1 353 ? -7.409  -26.420 -30.979 1.00 28.47  ? 616  GLU   A N   1 
ATOM   2474 C  CA  . GLU   A 1 353 ? -6.627  -25.195 -31.287 1.00 32.08  ? 616  GLU   A CA  1 
ATOM   2475 C  C   . GLU   A 1 353 ? -5.145  -25.447 -30.937 1.00 28.90  ? 616  GLU   A C   1 
ATOM   2476 O  O   . GLU   A 1 353 ? -4.278  -25.335 -31.809 1.00 28.39  ? 616  GLU   A O   1 
ATOM   2477 C  CB  . GLU   A 1 353 ? -7.251  -24.044 -30.502 1.00 30.00  ? 616  GLU   A CB  1 
ATOM   2478 C  CG  . GLU   A 1 353 ? -6.684  -22.684 -30.823 1.00 34.35  ? 616  GLU   A CG  1 
ATOM   2479 C  CD  . GLU   A 1 353 ? -6.960  -21.678 -29.714 1.00 39.39  ? 616  GLU   A CD  1 
ATOM   2480 O  OE1 . GLU   A 1 353 ? -8.173  -21.258 -29.540 1.00 37.49  ? 616  GLU   A OE1 1 
ATOM   2481 O  OE2 . GLU   A 1 353 ? -5.997  -21.408 -28.948 1.00 35.09  ? 616  GLU   A OE2 1 
ATOM   2482 N  N   . ALA   A 1 354 ? -4.869  -25.799 -29.694 1.00 28.29  ? 617  ALA   A N   1 
ATOM   2483 C  CA  . ALA   A 1 354 ? -3.498  -26.067 -29.221 1.00 30.91  ? 617  ALA   A CA  1 
ATOM   2484 C  C   . ALA   A 1 354 ? -2.821  -27.110 -30.121 1.00 32.21  ? 617  ALA   A C   1 
ATOM   2485 O  O   . ALA   A 1 354 ? -1.625  -26.926 -30.454 1.00 28.45  ? 617  ALA   A O   1 
ATOM   2486 C  CB  . ALA   A 1 354 ? -3.555  -26.517 -27.795 1.00 34.21  ? 617  ALA   A CB  1 
ATOM   2487 N  N   . GLN   A 1 355 ? -3.523  -28.181 -30.502 1.00 28.56  ? 618  GLN   A N   1 
ATOM   2488 C  CA  . GLN   A 1 355 ? -2.850  -29.255 -31.263 1.00 28.20  ? 618  GLN   A CA  1 
ATOM   2489 C  C   . GLN   A 1 355 ? -2.598  -28.836 -32.718 1.00 29.11  ? 618  GLN   A C   1 
ATOM   2490 O  O   . GLN   A 1 355 ? -1.576  -29.305 -33.265 1.00 30.57  ? 618  GLN   A O   1 
ATOM   2491 C  CB  . GLN   A 1 355 ? -3.550  -30.608 -31.172 1.00 25.79  ? 618  GLN   A CB  1 
ATOM   2492 C  CG  . GLN   A 1 355 ? -3.810  -31.066 -29.767 1.00 25.87  ? 618  GLN   A CG  1 
ATOM   2493 C  CD  . GLN   A 1 355 ? -2.538  -31.290 -29.000 1.00 28.96  ? 618  GLN   A CD  1 
ATOM   2494 O  OE1 . GLN   A 1 355 ? -1.532  -31.774 -29.496 1.00 30.23  ? 618  GLN   A OE1 1 
ATOM   2495 N  NE2 . GLN   A 1 355 ? -2.628  -31.056 -27.721 1.00 31.62  ? 618  GLN   A NE2 1 
ATOM   2496 N  N   . LEU   A 1 356 ? -3.463  -28.062 -33.378 1.00 30.53  ? 619  LEU   A N   1 
ATOM   2497 C  CA  . LEU   A 1 356 ? -3.150  -27.535 -34.746 1.00 31.75  ? 619  LEU   A CA  1 
ATOM   2498 C  C   . LEU   A 1 356 ? -1.915  -26.618 -34.675 1.00 31.31  ? 619  LEU   A C   1 
ATOM   2499 O  O   . LEU   A 1 356 ? -1.127  -26.638 -35.588 1.00 32.01  ? 619  LEU   A O   1 
ATOM   2500 C  CB  . LEU   A 1 356 ? -4.286  -26.691 -35.315 1.00 33.43  ? 619  LEU   A CB  1 
ATOM   2501 C  CG  . LEU   A 1 356 ? -5.450  -27.413 -35.959 1.00 35.76  ? 619  LEU   A CG  1 
ATOM   2502 C  CD1 . LEU   A 1 356 ? -6.543  -26.393 -36.205 1.00 35.81  ? 619  LEU   A CD1 1 
ATOM   2503 C  CD2 . LEU   A 1 356 ? -5.051  -28.118 -37.242 1.00 36.06  ? 619  LEU   A CD2 1 
ATOM   2504 N  N   . ILE   A 1 357 ? -1.813  -25.786 -33.654 1.00 31.07  ? 620  ILE   A N   1 
ATOM   2505 C  CA  . ILE   A 1 357 ? -0.668  -24.863 -33.481 1.00 34.84  ? 620  ILE   A CA  1 
ATOM   2506 C  C   . ILE   A 1 357 ? 0.608   -25.704 -33.263 1.00 41.94  ? 620  ILE   A C   1 
ATOM   2507 O  O   . ILE   A 1 357 ? 1.630   -25.403 -33.917 1.00 35.59  ? 620  ILE   A O   1 
ATOM   2508 C  CB  . ILE   A 1 357 ? -0.960  -23.869 -32.348 1.00 37.32  ? 620  ILE   A CB  1 
ATOM   2509 C  CG1 . ILE   A 1 357 ? -2.130  -22.941 -32.712 1.00 38.91  ? 620  ILE   A CG1 1 
ATOM   2510 C  CG2 . ILE   A 1 357 ? 0.296   -23.088 -31.984 1.00 36.81  ? 620  ILE   A CG2 1 
ATOM   2511 C  CD1 . ILE   A 1 357 ? -2.546  -21.988 -31.621 1.00 37.73  ? 620  ILE   A CD1 1 
ATOM   2512 N  N   . ARG   A 1 358 ? 0.549   -26.753 -32.430 1.00 36.19  ? 621  ARG   A N   1 
ATOM   2513 C  CA  . ARG   A 1 358 ? 1.698   -27.659 -32.238 1.00 32.03  ? 621  ARG   A CA  1 
ATOM   2514 C  C   . ARG   A 1 358 ? 2.087   -28.303 -33.566 1.00 32.99  ? 621  ARG   A C   1 
ATOM   2515 O  O   . ARG   A 1 358 ? 3.325   -28.453 -33.844 1.00 30.29  ? 621  ARG   A O   1 
ATOM   2516 C  CB  . ARG   A 1 358 ? 1.438   -28.728 -31.185 1.00 33.68  ? 621  ARG   A CB  1 
ATOM   2517 C  CG  . ARG   A 1 358 ? 2.712   -29.489 -30.858 1.00 32.68  ? 621  ARG   A CG  1 
ATOM   2518 C  CD  . ARG   A 1 358 ? 2.604   -30.463 -29.703 1.00 34.09  ? 621  ARG   A CD  1 
ATOM   2519 N  NE  . ARG   A 1 358 ? 3.783   -31.318 -29.652 1.00 34.17  ? 621  ARG   A NE  1 
ATOM   2520 C  CZ  . ARG   A 1 358 ? 3.982   -32.333 -28.815 1.00 33.26  ? 621  ARG   A CZ  1 
ATOM   2521 N  NH1 . ARG   A 1 358 ? 3.067   -32.714 -27.942 1.00 31.68  ? 621  ARG   A NH1 1 
ATOM   2522 N  NH2 . ARG   A 1 358 ? 5.130   -32.981 -28.872 1.00 40.51  ? 621  ARG   A NH2 1 
ATOM   2523 N  N   . GLN   A 1 359 ? 1.108   -28.712 -34.359 1.00 30.59  ? 622  GLN   A N   1 
ATOM   2524 C  CA  . GLN   A 1 359 ? 1.367   -29.223 -35.723 1.00 31.33  ? 622  GLN   A CA  1 
ATOM   2525 C  C   . GLN   A 1 359 ? 2.044   -28.100 -36.559 1.00 37.16  ? 622  GLN   A C   1 
ATOM   2526 O  O   . GLN   A 1 359 ? 2.990   -28.397 -37.312 1.00 39.76  ? 622  GLN   A O   1 
ATOM   2527 C  CB  . GLN   A 1 359 ? 0.084   -29.727 -36.389 1.00 30.84  ? 622  GLN   A CB  1 
ATOM   2528 C  CG  . GLN   A 1 359 ? -0.463  -31.036 -35.870 1.00 31.75  ? 622  GLN   A CG  1 
ATOM   2529 C  CD  . GLN   A 1 359 ? -1.437  -31.677 -36.833 1.00 31.87  ? 622  GLN   A CD  1 
ATOM   2530 O  OE1 . GLN   A 1 359 ? -1.087  -32.159 -37.909 1.00 29.22  ? 622  GLN   A OE1 1 
ATOM   2531 N  NE2 . GLN   A 1 359 ? -2.692  -31.742 -36.428 1.00 31.58  ? 622  GLN   A NE2 1 
ATOM   2532 N  N   . MET   A 1 360 ? 1.566   -26.857 -36.519 1.00 37.90  ? 623  MET   A N   1 
ATOM   2533 C  CA  . MET   A 1 360 ? 2.158   -25.745 -37.319 1.00 39.97  ? 623  MET   A CA  1 
ATOM   2534 C  C   . MET   A 1 360 ? 3.667   -25.612 -36.965 1.00 39.52  ? 623  MET   A C   1 
ATOM   2535 O  O   . MET   A 1 360 ? 4.500   -25.547 -37.887 1.00 36.32  ? 623  MET   A O   1 
ATOM   2536 C  CB  . MET   A 1 360 ? 1.461   -24.412 -37.018 1.00 42.56  ? 623  MET   A CB  1 
ATOM   2537 C  CG  . MET   A 1 360 ? 0.180   -24.169 -37.785 1.00 43.84  ? 623  MET   A CG  1 
ATOM   2538 S  SD  . MET   A 1 360 ? -0.618  -22.739 -37.062 1.00 41.29  ? 623  MET   A SD  1 
ATOM   2539 C  CE  . MET   A 1 360 ? -2.333  -23.114 -37.406 1.00 46.92  ? 623  MET   A CE  1 
ATOM   2540 N  N   . GLU   A 1 361 ? 3.992   -25.600 -35.678 1.00 31.80  ? 624  GLU   A N   1 
ATOM   2541 C  CA  . GLU   A 1 361 ? 5.365   -25.532 -35.156 1.00 35.98  ? 624  GLU   A CA  1 
ATOM   2542 C  C   . GLU   A 1 361 ? 6.178   -26.709 -35.715 1.00 40.30  ? 624  GLU   A C   1 
ATOM   2543 O  O   . GLU   A 1 361 ? 7.255   -26.463 -36.232 1.00 39.24  ? 624  GLU   A O   1 
ATOM   2544 C  CB  . GLU   A 1 361 ? 5.335   -25.481 -33.634 1.00 36.38  ? 624  GLU   A CB  1 
ATOM   2545 C  CG  . GLU   A 1 361 ? 6.707   -25.255 -33.041 1.00 37.96  ? 624  GLU   A CG  1 
ATOM   2546 C  CD  . GLU   A 1 361 ? 6.734   -24.887 -31.564 1.00 41.67  ? 624  GLU   A CD  1 
ATOM   2547 O  OE1 . GLU   A 1 361 ? 7.855   -24.791 -30.974 1.00 42.02  ? 624  GLU   A OE1 1 
ATOM   2548 O  OE2 . GLU   A 1 361 ? 5.641   -24.642 -31.000 1.00 43.29  ? 624  GLU   A OE2 1 
ATOM   2549 N  N   . GLY   A 1 362 ? 5.675   -27.936 -35.705 1.00 35.98  ? 625  GLY   A N   1 
ATOM   2550 C  CA  . GLY   A 1 362 ? 6.434   -29.068 -36.271 1.00 42.08  ? 625  GLY   A CA  1 
ATOM   2551 C  C   . GLY   A 1 362 ? 6.734   -28.890 -37.759 1.00 41.53  ? 625  GLY   A C   1 
ATOM   2552 O  O   . GLY   A 1 362 ? 7.799   -29.337 -38.230 1.00 38.84  ? 625  GLY   A O   1 
ATOM   2553 N  N   . GLU   A 1 363 ? 5.779   -28.347 -38.497 1.00 35.49  ? 626  GLU   A N   1 
ATOM   2554 C  CA  . GLU   A 1 363 ? 5.890   -28.115 -39.950 1.00 38.67  ? 626  GLU   A CA  1 
ATOM   2555 C  C   . GLU   A 1 363 ? 6.670   -26.805 -40.239 1.00 38.26  ? 626  GLU   A C   1 
ATOM   2556 O  O   . GLU   A 1 363 ? 6.855   -26.469 -41.391 1.00 39.55  ? 626  GLU   A O   1 
ATOM   2557 C  CB  . GLU   A 1 363 ? 4.479   -28.136 -40.534 1.00 36.08  ? 626  GLU   A CB  1 
ATOM   2558 C  CG  . GLU   A 1 363 ? 3.893   -29.552 -40.630 1.00 37.58  ? 626  GLU   A CG  1 
ATOM   2559 C  CD  . GLU   A 1 363 ? 2.473   -29.599 -41.171 1.00 40.73  ? 626  GLU   A CD  1 
ATOM   2560 O  OE1 . GLU   A 1 363 ? 2.259   -29.001 -42.249 1.00 39.07  ? 626  GLU   A OE1 1 
ATOM   2561 O  OE2 . GLU   A 1 363 ? 1.566   -30.206 -40.508 1.00 37.90  ? 626  GLU   A OE2 1 
ATOM   2562 N  N   . GLY   A 1 364 ? 7.156   -26.086 -39.242 1.00 35.68  ? 627  GLY   A N   1 
ATOM   2563 C  CA  . GLY   A 1 364 ? 7.892   -24.828 -39.481 1.00 40.20  ? 627  GLY   A CA  1 
ATOM   2564 C  C   . GLY   A 1 364 ? 7.055   -23.780 -40.204 1.00 48.93  ? 627  GLY   A C   1 
ATOM   2565 O  O   . GLY   A 1 364 ? 7.633   -23.093 -41.059 1.00 51.21  ? 627  GLY   A O   1 
ATOM   2566 N  N   . VAL   A 1 365 ? 5.752   -23.635 -39.884 1.00 41.59  ? 628  VAL   A N   1 
ATOM   2567 C  CA  . VAL   A 1 365 ? 4.874   -22.560 -40.430 1.00 42.27  ? 628  VAL   A CA  1 
ATOM   2568 C  C   . VAL   A 1 365 ? 5.314   -21.213 -39.830 1.00 44.36  ? 628  VAL   A C   1 
ATOM   2569 O  O   . VAL   A 1 365 ? 5.147   -20.176 -40.493 1.00 49.97  ? 628  VAL   A O   1 
ATOM   2570 C  CB  . VAL   A 1 365 ? 3.393   -22.871 -40.145 1.00 45.36  ? 628  VAL   A CB  1 
ATOM   2571 C  CG1 . VAL   A 1 365 ? 2.476   -21.784 -40.659 1.00 44.70  ? 628  VAL   A CG1 1 
ATOM   2572 C  CG2 . VAL   A 1 365 ? 2.987   -24.209 -40.740 1.00 49.28  ? 628  VAL   A CG2 1 
ATOM   2573 N  N   . PHE   A 1 366 ? 5.824   -21.225 -38.599 1.00 45.83  ? 629  PHE   A N   1 
ATOM   2574 C  CA  . PHE   A 1 366 ? 6.354   -20.049 -37.862 1.00 50.74  ? 629  PHE   A CA  1 
ATOM   2575 C  C   . PHE   A 1 366 ? 7.636   -20.475 -37.127 1.00 57.76  ? 629  PHE   A C   1 
ATOM   2576 O  O   . PHE   A 1 366 ? 7.823   -21.670 -36.849 1.00 60.76  ? 629  PHE   A O   1 
ATOM   2577 C  CB  . PHE   A 1 366 ? 5.282   -19.525 -36.909 1.00 49.65  ? 629  PHE   A CB  1 
ATOM   2578 C  CG  . PHE   A 1 366 ? 5.038   -20.391 -35.701 1.00 47.42  ? 629  PHE   A CG  1 
ATOM   2579 C  CD1 . PHE   A 1 366 ? 5.776   -20.220 -34.541 1.00 46.79  ? 629  PHE   A CD1 1 
ATOM   2580 C  CD2 . PHE   A 1 366 ? 4.060   -21.369 -35.723 1.00 47.35  ? 629  PHE   A CD2 1 
ATOM   2581 C  CE1 . PHE   A 1 366 ? 5.525   -21.006 -33.429 1.00 52.22  ? 629  PHE   A CE1 1 
ATOM   2582 C  CE2 . PHE   A 1 366 ? 3.812   -22.153 -34.611 1.00 42.22  ? 629  PHE   A CE2 1 
ATOM   2583 C  CZ  . PHE   A 1 366 ? 4.551   -21.984 -33.472 1.00 46.19  ? 629  PHE   A CZ  1 
ATOM   2584 N  N   . LYS   A 1 367 ? 8.492   -19.513 -36.772 0.50 56.34  ? 630  LYS   A N   1 
ATOM   2585 C  CA  . LYS   A 1 367 ? 9.819   -19.789 -36.156 0.50 55.39  ? 630  LYS   A CA  1 
ATOM   2586 C  C   . LYS   A 1 367 ? 9.817   -19.376 -34.680 0.50 51.74  ? 630  LYS   A C   1 
ATOM   2587 O  O   . LYS   A 1 367 ? 10.481  -20.056 -33.880 0.50 52.90  ? 630  LYS   A O   1 
ATOM   2588 C  CB  . LYS   A 1 367 ? 10.935  -19.060 -36.910 0.50 59.50  ? 630  LYS   A CB  1 
ATOM   2589 C  CG  . LYS   A 1 367 ? 12.304  -19.122 -36.238 0.50 62.95  ? 630  LYS   A CG  1 
ATOM   2590 C  CD  . LYS   A 1 367 ? 13.347  -18.198 -36.840 0.50 62.11  ? 630  LYS   A CD  1 
ATOM   2591 C  CE  . LYS   A 1 367 ? 14.356  -17.709 -35.822 0.50 62.19  ? 630  LYS   A CE  1 
ATOM   2592 N  NZ  . LYS   A 1 367 ? 13.770  -16.682 -34.928 0.50 61.40  ? 630  LYS   A NZ  1 
ATOM   2593 N  N   . SER   A 1 368 ? 9.117   -18.297 -34.330 0.50 47.55  ? 631  SER   A N   1 
ATOM   2594 C  CA  . SER   A 1 368 ? 9.238   -17.639 -33.004 0.50 47.41  ? 631  SER   A CA  1 
ATOM   2595 C  C   . SER   A 1 368 ? 7.867   -17.410 -32.373 0.50 46.97  ? 631  SER   A C   1 
ATOM   2596 O  O   . SER   A 1 368 ? 7.046   -16.704 -32.989 0.50 46.98  ? 631  SER   A O   1 
ATOM   2597 C  CB  . SER   A 1 368 ? 9.973   -16.335 -33.121 0.50 47.99  ? 631  SER   A CB  1 
ATOM   2598 O  OG  . SER   A 1 368 ? 9.580   -15.447 -32.084 0.50 48.72  ? 631  SER   A OG  1 
ATOM   2599 N  N   . ILE   A 1 369 ? 7.680   -17.877 -31.138 0.50 47.70  ? 632  ILE   A N   1 
ATOM   2600 C  CA  . ILE   A 1 369 ? 6.416   -17.592 -30.401 0.50 50.44  ? 632  ILE   A CA  1 
ATOM   2601 C  C   . ILE   A 1 369 ? 6.523   -16.174 -29.838 0.50 52.48  ? 632  ILE   A C   1 
ATOM   2602 O  O   . ILE   A 1 369 ? 5.500   -15.642 -29.380 0.50 49.00  ? 632  ILE   A O   1 
ATOM   2603 C  CB  . ILE   A 1 369 ? 6.200   -18.620 -29.276 0.50 48.28  ? 632  ILE   A CB  1 
ATOM   2604 C  CG1 . ILE   A 1 369 ? 7.245   -18.474 -28.168 0.50 48.19  ? 632  ILE   A CG1 1 
ATOM   2605 C  CG2 . ILE   A 1 369 ? 6.160   -20.033 -29.835 0.50 50.64  ? 632  ILE   A CG2 1 
ATOM   2606 C  CD1 . ILE   A 1 369 ? 6.978   -19.334 -26.959 0.50 49.09  ? 632  ILE   A CD1 1 
ATOM   2607 N  N   . GLN   A 1 370 ? 7.726   -15.598 -29.869 1.00 54.71  ? 633  GLN   A N   1 
ATOM   2608 C  CA  . GLN   A 1 370 ? 7.958   -14.253 -29.278 1.00 62.79  ? 633  GLN   A CA  1 
ATOM   2609 C  C   . GLN   A 1 370 ? 7.177   -13.202 -30.057 1.00 62.41  ? 633  GLN   A C   1 
ATOM   2610 O  O   . GLN   A 1 370 ? 6.556   -12.343 -29.423 1.00 57.77  ? 633  GLN   A O   1 
ATOM   2611 C  CB  . GLN   A 1 370 ? 9.445   -13.911 -29.318 1.00 65.75  ? 633  GLN   A CB  1 
ATOM   2612 C  CG  . GLN   A 1 370 ? 9.923   -13.155 -28.090 1.00 75.02  ? 633  GLN   A CG  1 
ATOM   2613 C  CD  . GLN   A 1 370 ? 10.120  -14.068 -26.907 1.00 78.12  ? 633  GLN   A CD  1 
ATOM   2614 O  OE1 . GLN   A 1 370 ? 10.232  -15.283 -27.049 1.00 84.01  ? 633  GLN   A OE1 1 
ATOM   2615 N  NE2 . GLN   A 1 370 ? 10.175  -13.484 -25.722 1.00 79.67  ? 633  GLN   A NE2 1 
ATOM   2616 N  N   . HIS   A 1 371 ? 7.234   -13.279 -31.382 0.50 62.84  ? 634  HIS   A N   1 
ATOM   2617 C  CA  . HIS   A 1 371 ? 6.546   -12.277 -32.230 0.50 66.02  ? 634  HIS   A CA  1 
ATOM   2618 C  C   . HIS   A 1 371 ? 6.294   -12.882 -33.608 0.50 66.37  ? 634  HIS   A C   1 
ATOM   2619 O  O   . HIS   A 1 371 ? 7.199   -13.546 -34.140 0.50 64.93  ? 634  HIS   A O   1 
ATOM   2620 C  CB  . HIS   A 1 371 ? 7.377   -10.993 -32.324 0.50 67.74  ? 634  HIS   A CB  1 
ATOM   2621 C  CG  . HIS   A 1 371 ? 7.090   -10.188 -33.546 0.50 67.82  ? 634  HIS   A CG  1 
ATOM   2622 N  ND1 . HIS   A 1 371 ? 7.834   -10.313 -34.702 0.50 69.29  ? 634  HIS   A ND1 1 
ATOM   2623 C  CD2 . HIS   A 1 371 ? 6.144   -9.260  -33.801 0.50 67.71  ? 634  HIS   A CD2 1 
ATOM   2624 C  CE1 . HIS   A 1 371 ? 7.362   -9.493  -35.617 0.50 68.72  ? 634  HIS   A CE1 1 
ATOM   2625 N  NE2 . HIS   A 1 371 ? 6.324   -8.834  -35.089 0.50 67.71  ? 634  HIS   A NE2 1 
ATOM   2626 N  N   . LEU   A 1 372 ? 5.109   -12.636 -34.159 1.00 68.26  ? 635  LEU   A N   1 
ATOM   2627 C  CA  . LEU   A 1 372 ? 4.793   -13.147 -35.510 1.00 71.18  ? 635  LEU   A CA  1 
ATOM   2628 C  C   . LEU   A 1 372 ? 4.997   -12.026 -36.523 1.00 67.13  ? 635  LEU   A C   1 
ATOM   2629 O  O   . LEU   A 1 372 ? 4.451   -10.942 -36.316 1.00 79.03  ? 635  LEU   A O   1 
ATOM   2630 C  CB  . LEU   A 1 372 ? 3.350   -13.654 -35.538 1.00 78.73  ? 635  LEU   A CB  1 
ATOM   2631 C  CG  . LEU   A 1 372 ? 3.120   -14.953 -36.307 1.00 78.51  ? 635  LEU   A CG  1 
ATOM   2632 C  CD1 . LEU   A 1 372 ? 3.814   -16.115 -35.615 1.00 78.93  ? 635  LEU   A CD1 1 
ATOM   2633 C  CD2 . LEU   A 1 372 ? 1.634   -15.236 -36.448 1.00 78.43  ? 635  LEU   A CD2 1 
ATOM   2634 N  N   . THR   A 1 373 ? 5.764   -12.301 -37.570 1.00 68.83  ? 636  THR   A N   1 
ATOM   2635 C  CA  . THR   A 1 373 ? 5.948   -11.311 -38.647 1.00 68.52  ? 636  THR   A CA  1 
ATOM   2636 C  C   . THR   A 1 373 ? 4.611   -11.125 -39.349 1.00 67.77  ? 636  THR   A C   1 
ATOM   2637 O  O   . THR   A 1 373 ? 3.694   -11.900 -39.070 1.00 69.91  ? 636  THR   A O   1 
ATOM   2638 C  CB  . THR   A 1 373 ? 7.019   -11.790 -39.625 1.00 67.41  ? 636  THR   A CB  1 
ATOM   2639 O  OG1 . THR   A 1 373 ? 6.476   -12.847 -40.415 1.00 69.33  ? 636  THR   A OG1 1 
ATOM   2640 C  CG2 . THR   A 1 373 ? 8.274   -12.261 -38.926 1.00 65.56  ? 636  THR   A CG2 1 
ATOM   2641 N  N   . VAL   A 1 374 ? 4.521   -10.131 -40.222 0.50 69.67  ? 637  VAL   A N   1 
ATOM   2642 C  CA  . VAL   A 1 374 ? 3.274   -9.899  -41.012 0.50 73.16  ? 637  VAL   A CA  1 
ATOM   2643 C  C   . VAL   A 1 374 ? 3.093   -11.050 -42.010 0.50 73.26  ? 637  VAL   A C   1 
ATOM   2644 O  O   . VAL   A 1 374 ? 1.948   -11.538 -42.146 0.50 69.14  ? 637  VAL   A O   1 
ATOM   2645 C  CB  . VAL   A 1 374 ? 3.288   -8.533  -41.726 0.50 76.15  ? 637  VAL   A CB  1 
ATOM   2646 C  CG1 . VAL   A 1 374 ? 3.061   -7.393  -40.745 0.50 78.10  ? 637  VAL   A CG1 1 
ATOM   2647 C  CG2 . VAL   A 1 374 ? 4.565   -8.312  -42.527 0.50 76.71  ? 637  VAL   A CG2 1 
ATOM   2648 N  N   . THR   A 1 375 ? 4.176   -11.467 -42.673 1.00 71.08  ? 638  THR   A N   1 
ATOM   2649 C  CA  . THR   A 1 375 ? 4.142   -12.544 -43.697 1.00 73.63  ? 638  THR   A CA  1 
ATOM   2650 C  C   . THR   A 1 375 ? 3.913   -13.905 -43.006 1.00 72.68  ? 638  THR   A C   1 
ATOM   2651 O  O   . THR   A 1 375 ? 3.436   -14.839 -43.692 1.00 64.47  ? 638  THR   A O   1 
ATOM   2652 C  CB  . THR   A 1 375 ? 5.393   -12.484 -44.582 1.00 77.24  ? 638  THR   A CB  1 
ATOM   2653 O  OG1 . THR   A 1 375 ? 6.514   -12.518 -43.703 1.00 86.08  ? 638  THR   A OG1 1 
ATOM   2654 C  CG2 . THR   A 1 375 ? 5.450   -11.246 -45.453 1.00 81.96  ? 638  THR   A CG2 1 
ATOM   2655 N  N   . GLU   A 1 376 ? 4.262   -14.032 -41.716 1.00 68.94  ? 639  GLU   A N   1 
ATOM   2656 C  CA  . GLU   A 1 376 ? 4.039   -15.277 -40.930 1.00 68.77  ? 639  GLU   A CA  1 
ATOM   2657 C  C   . GLU   A 1 376 ? 2.559   -15.368 -40.571 1.00 62.59  ? 639  GLU   A C   1 
ATOM   2658 O  O   . GLU   A 1 376 ? 2.065   -16.488 -40.575 1.00 59.14  ? 639  GLU   A O   1 
ATOM   2659 C  CB  . GLU   A 1 376 ? 4.940   -15.397 -39.699 1.00 62.34  ? 639  GLU   A CB  1 
ATOM   2660 C  CG  . GLU   A 1 376 ? 6.233   -16.127 -40.013 1.00 59.79  ? 639  GLU   A CG  1 
ATOM   2661 C  CD  . GLU   A 1 376 ? 7.228   -16.207 -38.877 1.00 59.68  ? 639  GLU   A CD  1 
ATOM   2662 O  OE1 . GLU   A 1 376 ? 8.110   -17.083 -38.935 1.00 67.68  ? 639  GLU   A OE1 1 
ATOM   2663 O  OE2 . GLU   A 1 376 ? 7.130   -15.382 -37.953 1.00 60.14  ? 639  GLU   A OE2 1 
ATOM   2664 N  N   . GLU   A 1 377 ? 1.871   -14.246 -40.353 1.00 57.89  ? 640  GLU   A N   1 
ATOM   2665 C  CA  . GLU   A 1 377 ? 0.393   -14.262 -40.179 1.00 58.28  ? 640  GLU   A CA  1 
ATOM   2666 C  C   . GLU   A 1 377 ? -0.284  -14.815 -41.430 1.00 60.43  ? 640  GLU   A C   1 
ATOM   2667 O  O   . GLU   A 1 377 ? -1.107  -15.718 -41.297 1.00 69.06  ? 640  GLU   A O   1 
ATOM   2668 C  CB  . GLU   A 1 377 ? -0.201  -12.910 -39.823 1.00 59.03  ? 640  GLU   A CB  1 
ATOM   2669 C  CG  . GLU   A 1 377 ? 0.156   -12.490 -38.419 1.00 67.40  ? 640  GLU   A CG  1 
ATOM   2670 C  CD  . GLU   A 1 377 ? -0.476  -11.177 -38.009 1.00 71.26  ? 640  GLU   A CD  1 
ATOM   2671 O  OE1 . GLU   A 1 377 ? -1.585  -10.889 -38.518 1.00 78.70  ? 640  GLU   A OE1 1 
ATOM   2672 O  OE2 . GLU   A 1 377 ? 0.133   -10.463 -37.169 1.00 70.19  ? 640  GLU   A OE2 1 
ATOM   2673 N  N   . ILE   A 1 378 ? 0.091   -14.307 -42.604 0.50 61.57  ? 641  ILE   A N   1 
ATOM   2674 C  CA  . ILE   A 1 378 ? -0.537  -14.768 -43.877 0.50 63.32  ? 641  ILE   A CA  1 
ATOM   2675 C  C   . ILE   A 1 378 ? -0.216  -16.254 -44.099 0.50 60.53  ? 641  ILE   A C   1 
ATOM   2676 O  O   . ILE   A 1 378 ? -1.091  -16.969 -44.611 0.50 63.18  ? 641  ILE   A O   1 
ATOM   2677 C  CB  . ILE   A 1 378 ? -0.114  -13.887 -45.074 0.50 63.84  ? 641  ILE   A CB  1 
ATOM   2678 C  CG1 . ILE   A 1 378 ? -0.361  -14.584 -46.415 0.50 66.69  ? 641  ILE   A CG1 1 
ATOM   2679 C  CG2 . ILE   A 1 378 ? 1.326   -13.427 -44.940 0.50 63.12  ? 641  ILE   A CG2 1 
ATOM   2680 C  CD1 . ILE   A 1 378 ? -1.821  -14.766 -46.753 0.50 68.17  ? 641  ILE   A CD1 1 
ATOM   2681 N  N   . ALA   A 1 379 ? 0.983   -16.698 -43.714 1.00 57.49  ? 642  ALA   A N   1 
ATOM   2682 C  CA  . ALA   A 1 379 ? 1.346   -18.128 -43.882 1.00 58.72  ? 642  ALA   A CA  1 
ATOM   2683 C  C   . ALA   A 1 379 ? 0.475   -19.019 -42.988 1.00 50.33  ? 642  ALA   A C   1 
ATOM   2684 O  O   . ALA   A 1 379 ? -0.039  -20.020 -43.493 1.00 45.66  ? 642  ALA   A O   1 
ATOM   2685 C  CB  . ALA   A 1 379 ? 2.805   -18.307 -43.574 1.00 52.13  ? 642  ALA   A CB  1 
ATOM   2686 N  N   . VAL   A 1 380 ? 0.350   -18.675 -41.712 1.00 44.93  ? 643  VAL   A N   1 
ATOM   2687 C  CA  . VAL   A 1 380 ? -0.514  -19.400 -40.740 1.00 48.41  ? 643  VAL   A CA  1 
ATOM   2688 C  C   . VAL   A 1 380 ? -1.925  -19.514 -41.336 1.00 48.73  ? 643  VAL   A C   1 
ATOM   2689 O  O   . VAL   A 1 380 ? -2.484  -20.636 -41.411 1.00 39.93  ? 643  VAL   A O   1 
ATOM   2690 C  CB  . VAL   A 1 380 ? -0.467  -18.714 -39.363 1.00 46.81  ? 643  VAL   A CB  1 
ATOM   2691 C  CG1 . VAL   A 1 380 ? -1.580  -19.162 -38.439 1.00 46.87  ? 643  VAL   A CG1 1 
ATOM   2692 C  CG2 . VAL   A 1 380 ? 0.879   -18.959 -38.693 1.00 48.98  ? 643  VAL   A CG2 1 
ATOM   2693 N  N   . LYS   A 1 381 ? -2.454  -18.394 -41.830 0.50 49.36  ? 644  LYS   A N   1 
ATOM   2694 C  CA  . LYS   A 1 381 ? -3.787  -18.309 -42.482 0.50 49.86  ? 644  LYS   A CA  1 
ATOM   2695 C  C   . LYS   A 1 381 ? -3.799  -19.198 -43.731 0.50 49.30  ? 644  LYS   A C   1 
ATOM   2696 O  O   . LYS   A 1 381 ? -4.739  -20.013 -43.864 0.50 49.30  ? 644  LYS   A O   1 
ATOM   2697 C  CB  . LYS   A 1 381 ? -4.109  -16.851 -42.809 0.50 53.37  ? 644  LYS   A CB  1 
ATOM   2698 C  CG  . LYS   A 1 381 ? -4.258  -15.951 -41.592 0.50 58.53  ? 644  LYS   A CG  1 
ATOM   2699 C  CD  . LYS   A 1 381 ? -4.159  -14.469 -41.905 0.50 60.93  ? 644  LYS   A CD  1 
ATOM   2700 C  CE  . LYS   A 1 381 ? -4.339  -13.594 -40.683 0.50 59.65  ? 644  LYS   A CE  1 
ATOM   2701 N  NZ  . LYS   A 1 381 ? -4.490  -12.169 -41.054 0.50 62.88  ? 644  LYS   A NZ  1 
ATOM   2702 N  N   . ASN   A 1 382 ? -2.793  -19.061 -44.599 0.50 46.48  ? 645  ASN   A N   1 
ATOM   2703 C  CA  . ASN   A 1 382 ? -2.660  -19.875 -45.838 0.50 47.89  ? 645  ASN   A CA  1 
ATOM   2704 C  C   . ASN   A 1 382 ? -2.700  -21.359 -45.461 0.50 46.50  ? 645  ASN   A C   1 
ATOM   2705 O  O   . ASN   A 1 382 ? -3.380  -22.141 -46.162 0.50 43.09  ? 645  ASN   A O   1 
ATOM   2706 C  CB  . ASN   A 1 382 ? -1.382  -19.539 -46.618 0.50 49.71  ? 645  ASN   A CB  1 
ATOM   2707 C  CG  . ASN   A 1 382 ? -1.608  -18.507 -47.704 0.50 53.31  ? 645  ASN   A CG  1 
ATOM   2708 O  OD1 . ASN   A 1 382 ? -0.760  -17.646 -47.948 0.50 54.53  ? 645  ASN   A OD1 1 
ATOM   2709 N  ND2 . ASN   A 1 382 ? -2.757  -18.581 -48.358 0.50 54.78  ? 645  ASN   A ND2 1 
ATOM   2710 N  N   . TRP   A 1 383 ? -1.985  -21.723 -44.392 1.00 47.65  ? 646  TRP   A N   1 
ATOM   2711 C  CA  . TRP   A 1 383 ? -1.850  -23.136 -43.933 1.00 43.44  ? 646  TRP   A CA  1 
ATOM   2712 C  C   . TRP   A 1 383 ? -3.246  -23.638 -43.506 1.00 35.93  ? 646  TRP   A C   1 
ATOM   2713 O  O   . TRP   A 1 383 ? -3.771  -24.589 -44.133 1.00 33.44  ? 646  TRP   A O   1 
ATOM   2714 C  CB  . TRP   A 1 383 ? -0.781  -23.185 -42.839 1.00 39.41  ? 646  TRP   A CB  1 
ATOM   2715 C  CG  . TRP   A 1 383 ? -0.406  -24.550 -42.360 1.00 44.63  ? 646  TRP   A CG  1 
ATOM   2716 C  CD1 . TRP   A 1 383 ? 0.598   -25.358 -42.813 1.00 45.85  ? 646  TRP   A CD1 1 
ATOM   2717 C  CD2 . TRP   A 1 383 ? -1.019  -25.255 -41.274 1.00 43.34  ? 646  TRP   A CD2 1 
ATOM   2718 N  NE1 . TRP   A 1 383 ? 0.650   -26.516 -42.085 1.00 43.52  ? 646  TRP   A NE1 1 
ATOM   2719 C  CE2 . TRP   A 1 383 ? -0.320  -26.473 -41.124 1.00 43.38  ? 646  TRP   A CE2 1 
ATOM   2720 C  CE3 . TRP   A 1 383 ? -2.058  -24.954 -40.394 1.00 39.87  ? 646  TRP   A CE3 1 
ATOM   2721 C  CZ2 . TRP   A 1 383 ? -0.652  -27.392 -40.135 1.00 40.57  ? 646  TRP   A CZ2 1 
ATOM   2722 C  CZ3 . TRP   A 1 383 ? -2.387  -25.867 -39.417 1.00 40.79  ? 646  TRP   A CZ3 1 
ATOM   2723 C  CH2 . TRP   A 1 383 ? -1.685  -27.061 -39.286 1.00 40.89  ? 646  TRP   A CH2 1 
ATOM   2724 N  N   . LEU   A 1 384 ? -3.915  -22.893 -42.634 1.00 33.77  ? 647  LEU   A N   1 
ATOM   2725 C  CA  . LEU   A 1 384 ? -5.266  -23.258 -42.124 1.00 40.93  ? 647  LEU   A CA  1 
ATOM   2726 C  C   . LEU   A 1 384 ? -6.232  -23.485 -43.299 1.00 42.17  ? 647  LEU   A C   1 
ATOM   2727 O  O   . LEU   A 1 384 ? -6.882  -24.528 -43.341 1.00 38.11  ? 647  LEU   A O   1 
ATOM   2728 C  CB  . LEU   A 1 384 ? -5.755  -22.169 -41.163 1.00 36.73  ? 647  LEU   A CB  1 
ATOM   2729 C  CG  . LEU   A 1 384 ? -5.100  -22.194 -39.778 1.00 40.50  ? 647  LEU   A CG  1 
ATOM   2730 C  CD1 . LEU   A 1 384 ? -5.439  -20.940 -38.978 1.00 41.06  ? 647  LEU   A CD1 1 
ATOM   2731 C  CD2 . LEU   A 1 384 ? -5.496  -23.425 -38.983 1.00 40.17  ? 647  LEU   A CD2 1 
ATOM   2732 N  N   . VAL   A 1 385 ? -6.262  -22.563 -44.257 1.00 49.16  ? 648  VAL   A N   1 
ATOM   2733 C  CA  . VAL   A 1 385 ? -7.181  -22.584 -45.427 1.00 46.97  ? 648  VAL   A CA  1 
ATOM   2734 C  C   . VAL   A 1 385 ? -6.795  -23.738 -46.351 1.00 47.36  ? 648  VAL   A C   1 
ATOM   2735 O  O   . VAL   A 1 385 ? -7.680  -24.422 -46.878 1.00 47.55  ? 648  VAL   A O   1 
ATOM   2736 C  CB  . VAL   A 1 385 ? -7.148  -21.210 -46.137 1.00 55.54  ? 648  VAL   A CB  1 
ATOM   2737 C  CG1 . VAL   A 1 385 ? -7.700  -21.268 -47.551 1.00 54.86  ? 648  VAL   A CG1 1 
ATOM   2738 C  CG2 . VAL   A 1 385 ? -7.901  -20.155 -45.328 1.00 54.59  ? 648  VAL   A CG2 1 
ATOM   2739 N  N   . ARG   A 1 386 ? -5.492  -23.951 -46.543 0.50 48.05  ? 649  ARG   A N   1 
ATOM   2740 C  CA  . ARG   A 1 386 ? -4.947  -24.947 -47.502 0.50 51.54  ? 649  ARG   A CA  1 
ATOM   2741 C  C   . ARG   A 1 386 ? -5.068  -26.367 -46.919 0.50 50.45  ? 649  ARG   A C   1 
ATOM   2742 O  O   . ARG   A 1 386 ? -5.498  -27.273 -47.664 0.50 49.04  ? 649  ARG   A O   1 
ATOM   2743 C  CB  . ARG   A 1 386 ? -3.498  -24.585 -47.852 0.50 57.05  ? 649  ARG   A CB  1 
ATOM   2744 C  CG  . ARG   A 1 386 ? -2.928  -25.351 -49.039 0.50 61.94  ? 649  ARG   A CG  1 
ATOM   2745 C  CD  . ARG   A 1 386 ? -1.526  -24.904 -49.435 0.50 67.17  ? 649  ARG   A CD  1 
ATOM   2746 N  NE  . ARG   A 1 386 ? -0.496  -25.245 -48.455 0.50 68.82  ? 649  ARG   A NE  1 
ATOM   2747 C  CZ  . ARG   A 1 386 ? 0.047   -24.385 -47.597 0.50 68.34  ? 649  ARG   A CZ  1 
ATOM   2748 N  NH1 . ARG   A 1 386 ? -0.340  -23.121 -47.589 0.50 70.25  ? 649  ARG   A NH1 1 
ATOM   2749 N  NH2 . ARG   A 1 386 ? 0.977   -24.791 -46.750 0.50 66.58  ? 649  ARG   A NH2 1 
ATOM   2750 N  N   . VAL   A 1 387 ? -4.701  -26.569 -45.647 1.00 46.41  ? 650  VAL   A N   1 
ATOM   2751 C  CA  . VAL   A 1 387 ? -4.590  -27.952 -45.081 1.00 47.13  ? 650  VAL   A CA  1 
ATOM   2752 C  C   . VAL   A 1 387 ? -5.256  -28.128 -43.709 1.00 42.82  ? 650  VAL   A C   1 
ATOM   2753 O  O   . VAL   A 1 387 ? -5.151  -29.291 -43.191 1.00 35.07  ? 650  VAL   A O   1 
ATOM   2754 C  CB  . VAL   A 1 387 ? -3.111  -28.394 -45.025 1.00 43.28  ? 650  VAL   A CB  1 
ATOM   2755 C  CG1 . VAL   A 1 387 ? -2.496  -28.462 -46.405 1.00 41.87  ? 650  VAL   A CG1 1 
ATOM   2756 C  CG2 . VAL   A 1 387 ? -2.290  -27.514 -44.094 1.00 40.86  ? 650  VAL   A CG2 1 
ATOM   2757 N  N   . GLY   A 1 388 ? -5.880  -27.080 -43.151 1.00 37.11  ? 651  GLY   A N   1 
ATOM   2758 C  CA  . GLY   A 1 388 ? -6.483  -27.089 -41.800 1.00 36.62  ? 651  GLY   A CA  1 
ATOM   2759 C  C   . GLY   A 1 388 ? -7.367  -28.308 -41.596 1.00 36.19  ? 651  GLY   A C   1 
ATOM   2760 O  O   . GLY   A 1 388 ? -7.216  -29.030 -40.594 1.00 34.32  ? 651  GLY   A O   1 
ATOM   2761 N  N   . ARG   A 1 389 ? -8.232  -28.596 -42.547 1.00 35.17  ? 652  ARG   A N   1 
ATOM   2762 C  CA  . ARG   A 1 389 ? -9.215  -29.687 -42.382 1.00 39.27  ? 652  ARG   A CA  1 
ATOM   2763 C  C   . ARG   A 1 389 ? -8.431  -30.996 -42.431 1.00 35.99  ? 652  ARG   A C   1 
ATOM   2764 O  O   . ARG   A 1 389 ? -8.770  -31.935 -41.676 1.00 37.90  ? 652  ARG   A O   1 
ATOM   2765 C  CB  . ARG   A 1 389 ? -10.297 -29.625 -43.469 1.00 39.39  ? 652  ARG   A CB  1 
ATOM   2766 C  CG  . ARG   A 1 389 ? -11.205 -28.409 -43.366 1.00 40.57  ? 652  ARG   A CG  1 
ATOM   2767 C  CD  . ARG   A 1 389 ? -12.271 -28.380 -44.453 1.00 41.34  ? 652  ARG   A CD  1 
ATOM   2768 N  NE  . ARG   A 1 389 ? -13.216 -29.482 -44.369 1.00 44.74  ? 652  ARG   A NE  1 
ATOM   2769 C  CZ  . ARG   A 1 389 ? -14.293 -29.506 -43.578 1.00 43.27  ? 652  ARG   A CZ  1 
ATOM   2770 N  NH1 . ARG   A 1 389 ? -14.546 -28.516 -42.733 1.00 41.41  ? 652  ARG   A NH1 1 
ATOM   2771 N  NH2 . ARG   A 1 389 ? -15.057 -30.578 -43.564 1.00 43.29  ? 652  ARG   A NH2 1 
ATOM   2772 N  N   . GLU   A 1 390 ? -7.454  -31.104 -43.329 1.00 33.37  ? 653  GLU   A N   1 
ATOM   2773 C  CA  . GLU   A 1 390 ? -6.662  -32.365 -43.408 1.00 36.56  ? 653  GLU   A CA  1 
ATOM   2774 C  C   . GLU   A 1 390 ? -5.962  -32.618 -42.054 1.00 33.42  ? 653  GLU   A C   1 
ATOM   2775 O  O   . GLU   A 1 390 ? -5.991  -33.768 -41.592 1.00 34.31  ? 653  GLU   A O   1 
ATOM   2776 C  CB  . GLU   A 1 390 ? -5.681  -32.371 -44.578 1.00 35.26  ? 653  GLU   A CB  1 
ATOM   2777 C  CG  . GLU   A 1 390 ? -5.201  -33.773 -44.934 1.00 34.14  ? 653  GLU   A CG  1 
ATOM   2778 C  CD  . GLU   A 1 390 ? -4.069  -34.356 -44.087 1.00 36.85  ? 653  GLU   A CD  1 
ATOM   2779 O  OE1 . GLU   A 1 390 ? -3.406  -33.607 -43.334 1.00 34.06  ? 653  GLU   A OE1 1 
ATOM   2780 O  OE2 . GLU   A 1 390 ? -3.876  -35.588 -44.137 1.00 44.12  ? 653  GLU   A OE2 1 
ATOM   2781 N  N   . ARG   A 1 391 ? -5.467  -31.569 -41.401 1.00 32.38  ? 654  ARG   A N   1 
ATOM   2782 C  CA  . ARG   A 1 391 ? -4.701  -31.664 -40.144 1.00 32.30  ? 654  ARG   A CA  1 
ATOM   2783 C  C   . ARG   A 1 391 ? -5.670  -31.969 -38.997 1.00 31.26  ? 654  ARG   A C   1 
ATOM   2784 O  O   . ARG   A 1 391 ? -5.242  -32.645 -38.042 1.00 27.12  ? 654  ARG   A O   1 
ATOM   2785 C  CB  . ARG   A 1 391 ? -3.875  -30.393 -39.906 1.00 33.82  ? 654  ARG   A CB  1 
ATOM   2786 C  CG  . ARG   A 1 391 ? -2.848  -30.104 -40.996 1.00 34.95  ? 654  ARG   A CG  1 
ATOM   2787 C  CD  . ARG   A 1 391 ? -1.788  -31.181 -41.078 1.00 41.28  ? 654  ARG   A CD  1 
ATOM   2788 N  NE  . ARG   A 1 391 ? -0.679  -30.716 -41.886 1.00 42.60  ? 654  ARG   A NE  1 
ATOM   2789 C  CZ  . ARG   A 1 391 ? -0.580  -30.869 -43.202 1.00 43.91  ? 654  ARG   A CZ  1 
ATOM   2790 N  NH1 . ARG   A 1 391 ? -1.488  -31.532 -43.894 1.00 43.30  ? 654  ARG   A NH1 1 
ATOM   2791 N  NH2 . ARG   A 1 391 ? 0.467   -30.389 -43.840 1.00 51.04  ? 654  ARG   A NH2 1 
ATOM   2792 N  N   . LEU   A 1 392 ? -6.929  -31.514 -39.070 1.00 30.12  ? 655  LEU   A N   1 
ATOM   2793 C  CA  . LEU   A 1 392 ? -7.941  -31.848 -38.020 1.00 30.55  ? 655  LEU   A CA  1 
ATOM   2794 C  C   . LEU   A 1 392 ? -8.253  -33.342 -38.115 1.00 29.01  ? 655  LEU   A C   1 
ATOM   2795 O  O   . LEU   A 1 392 ? -8.461  -33.985 -37.082 1.00 27.58  ? 655  LEU   A O   1 
ATOM   2796 C  CB  . LEU   A 1 392 ? -9.225  -31.033 -38.172 1.00 31.51  ? 655  LEU   A CB  1 
ATOM   2797 C  CG  . LEU   A 1 392 ? -9.164  -29.549 -37.825 1.00 30.70  ? 655  LEU   A CG  1 
ATOM   2798 C  CD1 . LEU   A 1 392 ? -10.489 -28.892 -38.210 1.00 34.03  ? 655  LEU   A CD1 1 
ATOM   2799 C  CD2 . LEU   A 1 392 ? -8.859  -29.324 -36.347 1.00 30.25  ? 655  LEU   A CD2 1 
ATOM   2800 N  N   . SER   A 1 393 ? -8.283  -33.885 -39.318 1.00 28.56  ? 656  SER   A N   1 
ATOM   2801 C  CA  . SER   A 1 393 ? -8.654  -35.304 -39.505 1.00 31.25  ? 656  SER   A CA  1 
ATOM   2802 C  C   . SER   A 1 393 ? -7.559  -36.221 -38.988 1.00 31.34  ? 656  SER   A C   1 
ATOM   2803 O  O   . SER   A 1 393 ? -7.828  -37.409 -38.973 1.00 28.79  ? 656  SER   A O   1 
ATOM   2804 C  CB  . SER   A 1 393 ? -8.967  -35.613 -40.934 1.00 32.71  ? 656  SER   A CB  1 
ATOM   2805 O  OG  . SER   A 1 393 ? -7.809  -35.448 -41.730 1.00 38.86  ? 656  SER   A OG  1 
ATOM   2806 N  N   . ARG   A 1 394 ? -6.362  -35.694 -38.665 1.00 30.39  ? 657  ARG   A N   1 
ATOM   2807 C  CA  . ARG   A 1 394 ? -5.205  -36.476 -38.145 1.00 30.08  ? 657  ARG   A CA  1 
ATOM   2808 C  C   . ARG   A 1 394 ? -5.287  -36.599 -36.624 1.00 28.59  ? 657  ARG   A C   1 
ATOM   2809 O  O   . ARG   A 1 394 ? -4.287  -37.050 -35.987 1.00 28.05  ? 657  ARG   A O   1 
ATOM   2810 C  CB  . ARG   A 1 394 ? -3.882  -35.740 -38.415 1.00 32.82  ? 657  ARG   A CB  1 
ATOM   2811 C  CG  . ARG   A 1 394 ? -3.551  -35.608 -39.883 1.00 34.19  ? 657  ARG   A CG  1 
ATOM   2812 C  CD  . ARG   A 1 394 ? -2.219  -34.923 -40.129 1.00 34.53  ? 657  ARG   A CD  1 
ATOM   2813 N  NE  . ARG   A 1 394 ? -1.939  -35.385 -41.468 1.00 34.53  ? 657  ARG   A NE  1 
ATOM   2814 C  CZ  . ARG   A 1 394 ? -1.232  -36.454 -41.764 1.00 36.41  ? 657  ARG   A CZ  1 
ATOM   2815 N  NH1 . ARG   A 1 394 ? -0.618  -37.168 -40.834 1.00 38.90  ? 657  ARG   A NH1 1 
ATOM   2816 N  NH2 . ARG   A 1 394 ? -1.125  -36.811 -43.019 1.00 38.76  ? 657  ARG   A NH2 1 
ATOM   2817 N  N   . MET   A 1 395 ? -6.367  -36.094 -36.049 1.00 25.32  ? 658  MET   A N   1 
ATOM   2818 C  CA  . MET   A 1 395 ? -6.558  -36.049 -34.586 1.00 26.15  ? 658  MET   A CA  1 
ATOM   2819 C  C   . MET   A 1 395 ? -7.881  -36.706 -34.161 1.00 26.63  ? 658  MET   A C   1 
ATOM   2820 O  O   . MET   A 1 395 ? -8.856  -36.705 -34.900 1.00 23.00  ? 658  MET   A O   1 
ATOM   2821 C  CB  . MET   A 1 395 ? -6.471  -34.583 -34.140 1.00 27.34  ? 658  MET   A CB  1 
ATOM   2822 C  CG  . MET   A 1 395 ? -5.158  -33.927 -34.577 1.00 30.23  ? 658  MET   A CG  1 
ATOM   2823 S  SD  . MET   A 1 395 ? -4.839  -32.366 -33.753 1.00 28.83  ? 658  MET   A SD  1 
ATOM   2824 C  CE  . MET   A 1 395 ? -6.048  -31.311 -34.537 1.00 29.29  ? 658  MET   A CE  1 
ATOM   2825 N  N   . ALA   A 1 396 ? -7.855  -37.288 -32.976 1.00 26.94  ? 659  ALA   A N   1 
ATOM   2826 C  CA  . ALA   A 1 396 ? -9.017  -37.673 -32.174 1.00 27.52  ? 659  ALA   A CA  1 
ATOM   2827 C  C   . ALA   A 1 396 ? -8.906  -36.940 -30.828 1.00 26.17  ? 659  ALA   A C   1 
ATOM   2828 O  O   . ALA   A 1 396 ? -7.944  -37.167 -30.112 1.00 25.76  ? 659  ALA   A O   1 
ATOM   2829 C  CB  . ALA   A 1 396 ? -9.008  -39.180 -32.023 1.00 29.14  ? 659  ALA   A CB  1 
ATOM   2830 N  N   . ILE   A 1 397 ? -9.870  -36.092 -30.517 1.00 24.56  ? 660  ILE   A N   1 
ATOM   2831 C  CA  . ILE   A 1 397 ? -9.845  -35.160 -29.372 1.00 25.19  ? 660  ILE   A CA  1 
ATOM   2832 C  C   . ILE   A 1 397 ? -11.179 -35.262 -28.629 1.00 27.60  ? 660  ILE   A C   1 
ATOM   2833 O  O   . ILE   A 1 397 ? -12.241 -35.024 -29.217 1.00 26.02  ? 660  ILE   A O   1 
ATOM   2834 C  CB  . ILE   A 1 397 ? -9.531  -33.735 -29.859 1.00 24.56  ? 660  ILE   A CB  1 
ATOM   2835 C  CG1 . ILE   A 1 397 ? -8.197  -33.738 -30.626 1.00 30.65  ? 660  ILE   A CG1 1 
ATOM   2836 C  CG2 . ILE   A 1 397 ? -9.538  -32.813 -28.672 1.00 24.51  ? 660  ILE   A CG2 1 
ATOM   2837 C  CD1 . ILE   A 1 397 ? -7.522  -32.401 -30.858 1.00 28.14  ? 660  ILE   A CD1 1 
ATOM   2838 N  N   . SER   A 1 398 ? -11.081 -35.621 -27.362 1.00 28.58  ? 661  SER   A N   1 
ATOM   2839 C  CA  . SER   A 1 398 ? -12.188 -35.762 -26.404 1.00 30.26  ? 661  SER   A CA  1 
ATOM   2840 C  C   . SER   A 1 398 ? -11.862 -34.862 -25.224 1.00 31.54  ? 661  SER   A C   1 
ATOM   2841 O  O   . SER   A 1 398 ? -11.057 -35.296 -24.387 1.00 31.17  ? 661  SER   A O   1 
ATOM   2842 C  CB  . SER   A 1 398 ? -12.335 -37.188 -25.990 1.00 30.08  ? 661  SER   A CB  1 
ATOM   2843 O  OG  . SER   A 1 398 ? -13.593 -37.400 -25.386 1.00 27.64  ? 661  SER   A OG  1 
ATOM   2844 N  N   . GLY   A 1 399 ? -12.385 -33.635 -25.201 1.00 27.30  ? 662  GLY   A N   1 
ATOM   2845 C  CA  . GLY   A 1 399 ? -12.017 -32.688 -24.123 1.00 27.45  ? 662  GLY   A CA  1 
ATOM   2846 C  C   . GLY   A 1 399 ? -10.508 -32.535 -24.017 1.00 27.47  ? 662  GLY   A C   1 
ATOM   2847 O  O   . GLY   A 1 399 ? -9.847  -32.229 -25.067 1.00 27.26  ? 662  GLY   A O   1 
ATOM   2848 N  N   . ASP   A 1 400 ? -9.948  -32.735 -22.828 1.00 28.36  ? 663  ASP   A N   1 
ATOM   2849 C  CA  . ASP   A 1 400 ? -8.493  -32.564 -22.599 1.00 29.77  ? 663  ASP   A CA  1 
ATOM   2850 C  C   . ASP   A 1 400 ? -7.709  -33.769 -23.122 1.00 29.93  ? 663  ASP   A C   1 
ATOM   2851 O  O   . ASP   A 1 400 ? -6.489  -33.707 -23.070 1.00 29.09  ? 663  ASP   A O   1 
ATOM   2852 C  CB  . ASP   A 1 400 ? -8.206  -32.270 -21.127 1.00 36.64  ? 663  ASP   A CB  1 
ATOM   2853 C  CG  . ASP   A 1 400 ? -8.452  -33.430 -20.182 1.00 38.77  ? 663  ASP   A CG  1 
ATOM   2854 O  OD1 . ASP   A 1 400 ? -9.203  -34.310 -20.527 1.00 38.30  ? 663  ASP   A OD1 1 
ATOM   2855 O  OD2 . ASP   A 1 400 ? -7.861  -33.425 -19.111 1.00 48.59  ? 663  ASP   A OD2 1 
ATOM   2856 N  N   . ASP   A 1 401 ? -8.360  -34.787 -23.678 1.00 28.53  ? 664  ASP   A N   1 
ATOM   2857 C  CA  . ASP   A 1 401 ? -7.669  -36.009 -24.167 1.00 27.63  ? 664  ASP   A CA  1 
ATOM   2858 C  C   . ASP   A 1 401 ? -7.485  -35.956 -25.681 1.00 27.36  ? 664  ASP   A C   1 
ATOM   2859 O  O   . ASP   A 1 401 ? -8.456  -35.645 -26.363 1.00 31.88  ? 664  ASP   A O   1 
ATOM   2860 C  CB  . ASP   A 1 401 ? -8.441  -37.273 -23.782 1.00 29.43  ? 664  ASP   A CB  1 
ATOM   2861 C  CG  . ASP   A 1 401 ? -7.513  -38.463 -23.630 1.00 29.80  ? 664  ASP   A CG  1 
ATOM   2862 O  OD1 . ASP   A 1 401 ? -6.334  -38.206 -23.589 1.00 35.54  ? 664  ASP   A OD1 1 
ATOM   2863 O  OD2 . ASP   A 1 401 ? -7.967  -39.595 -23.617 1.00 32.87  ? 664  ASP   A OD2 1 
ATOM   2864 N  N   . CYS   A 1 402 ? -6.275  -36.228 -26.184 1.00 24.69  ? 665  CYS   A N   1 
ATOM   2865 C  CA  . CYS   A 1 402 ? -5.973  -36.221 -27.631 1.00 24.87  ? 665  CYS   A CA  1 
ATOM   2866 C  C   . CYS   A 1 402 ? -5.047  -37.363 -28.046 1.00 29.29  ? 665  CYS   A C   1 
ATOM   2867 O  O   . CYS   A 1 402 ? -4.168  -37.802 -27.235 1.00 27.82  ? 665  CYS   A O   1 
ATOM   2868 C  CB  . CYS   A 1 402 ? -5.328  -34.912 -28.064 1.00 28.35  ? 665  CYS   A CB  1 
ATOM   2869 S  SG  . CYS   A 1 402 ? -3.659  -34.645 -27.388 1.00 33.33  ? 665  CYS   A SG  1 
ATOM   2870 N  N   . VAL   A 1 403 ? -5.187  -37.709 -29.324 1.00 27.42  ? 666  VAL   A N   1 
ATOM   2871 C  CA  . VAL   A 1 403 ? -4.255  -38.548 -30.118 1.00 29.86  ? 666  VAL   A CA  1 
ATOM   2872 C  C   . VAL   A 1 403 ? -4.024  -37.779 -31.415 1.00 30.08  ? 666  VAL   A C   1 
ATOM   2873 O  O   . VAL   A 1 403 ? -5.015  -37.324 -32.009 1.00 30.26  ? 666  VAL   A O   1 
ATOM   2874 C  CB  . VAL   A 1 403 ? -4.856  -39.943 -30.350 1.00 27.68  ? 666  VAL   A CB  1 
ATOM   2875 C  CG1 . VAL   A 1 403 ? -4.003  -40.810 -31.258 1.00 28.47  ? 666  VAL   A CG1 1 
ATOM   2876 C  CG2 . VAL   A 1 403 ? -5.131  -40.622 -29.015 1.00 27.55  ? 666  VAL   A CG2 1 
ATOM   2877 N  N   . VAL   A 1 404 ? -2.767  -37.536 -31.762 1.00 28.37  ? 667  VAL   A N   1 
ATOM   2878 C  CA  . VAL   A 1 404 ? -2.374  -36.808 -33.012 1.00 27.39  ? 667  VAL   A CA  1 
ATOM   2879 C  C   . VAL   A 1 404 ? -1.455  -37.693 -33.825 1.00 25.74  ? 667  VAL   A C   1 
ATOM   2880 O  O   . VAL   A 1 404 ? -0.457  -38.215 -33.261 1.00 26.42  ? 667  VAL   A O   1 
ATOM   2881 C  CB  . VAL   A 1 404 ? -1.678  -35.469 -32.721 1.00 28.09  ? 667  VAL   A CB  1 
ATOM   2882 C  CG1 . VAL   A 1 404 ? -1.367  -34.701 -33.997 1.00 28.18  ? 667  VAL   A CG1 1 
ATOM   2883 C  CG2 . VAL   A 1 404 ? -2.500  -34.602 -31.776 1.00 29.27  ? 667  VAL   A CG2 1 
ATOM   2884 N  N   . LYS   A 1 405 ? -1.773  -37.839 -35.104 1.00 27.51  ? 668  LYS   A N   1 
ATOM   2885 C  CA  . LYS   A 1 405 ? -0.843  -38.418 -36.085 1.00 31.35  ? 668  LYS   A CA  1 
ATOM   2886 C  C   . LYS   A 1 405 ? -0.338  -37.311 -37.005 1.00 32.60  ? 668  LYS   A C   1 
ATOM   2887 O  O   . LYS   A 1 405 ? -0.885  -37.089 -38.093 1.00 27.00  ? 668  LYS   A O   1 
ATOM   2888 C  CB  . LYS   A 1 405 ? -1.443  -39.552 -36.902 1.00 32.86  ? 668  LYS   A CB  1 
ATOM   2889 C  CG  . LYS   A 1 405 ? -0.356  -40.180 -37.746 1.00 35.13  ? 668  LYS   A CG  1 
ATOM   2890 C  CD  . LYS   A 1 405 ? -0.586  -41.582 -38.223 1.00 36.54  ? 668  LYS   A CD  1 
ATOM   2891 C  CE  . LYS   A 1 405 ? 0.580   -41.939 -39.120 1.00 38.04  ? 668  LYS   A CE  1 
ATOM   2892 N  NZ  . LYS   A 1 405 ? 0.532   -43.349 -39.518 1.00 42.62  ? 668  LYS   A NZ  1 
ATOM   2893 N  N   . PRO   A 1 406 ? 0.775   -36.644 -36.626 1.00 31.47  ? 669  PRO   A N   1 
ATOM   2894 C  CA  . PRO   A 1 406 ? 1.298   -35.533 -37.406 1.00 32.18  ? 669  PRO   A CA  1 
ATOM   2895 C  C   . PRO   A 1 406 ? 1.938   -36.006 -38.711 1.00 30.50  ? 669  PRO   A C   1 
ATOM   2896 O  O   . PRO   A 1 406 ? 2.159   -37.203 -38.948 1.00 31.11  ? 669  PRO   A O   1 
ATOM   2897 C  CB  . PRO   A 1 406 ? 2.353   -34.958 -36.475 1.00 31.55  ? 669  PRO   A CB  1 
ATOM   2898 C  CG  . PRO   A 1 406 ? 2.895   -36.213 -35.850 1.00 32.31  ? 669  PRO   A CG  1 
ATOM   2899 C  CD  . PRO   A 1 406 ? 1.645   -36.971 -35.493 1.00 30.98  ? 669  PRO   A CD  1 
ATOM   2900 N  N   . LEU   A 1 407 ? 2.229   -35.029 -39.547 1.00 32.82  ? 670  LEU   A N   1 
ATOM   2901 C  CA  . LEU   A 1 407 ? 2.866   -35.227 -40.871 1.00 35.21  ? 670  LEU   A CA  1 
ATOM   2902 C  C   . LEU   A 1 407 ? 4.182   -36.015 -40.697 1.00 35.16  ? 670  LEU   A C   1 
ATOM   2903 O  O   . LEU   A 1 407 ? 4.465   -36.873 -41.542 1.00 32.99  ? 670  LEU   A O   1 
ATOM   2904 C  CB  . LEU   A 1 407 ? 3.085   -33.832 -41.455 1.00 37.55  ? 670  LEU   A CB  1 
ATOM   2905 C  CG  . LEU   A 1 407 ? 2.977   -33.757 -42.963 1.00 42.74  ? 670  LEU   A CG  1 
ATOM   2906 C  CD1 . LEU   A 1 407 ? 1.543   -33.957 -43.381 1.00 45.45  ? 670  LEU   A CD1 1 
ATOM   2907 C  CD2 . LEU   A 1 407 ? 3.509   -32.424 -43.473 1.00 48.87  ? 670  LEU   A CD2 1 
ATOM   2908 N  N   . ASP   A 1 408 ? 4.925   -35.792 -39.604 1.00 32.00  ? 671  ASP   A N   1 
ATOM   2909 C  CA  . ASP   A 1 408 ? 6.211   -36.497 -39.344 1.00 33.13  ? 671  ASP   A CA  1 
ATOM   2910 C  C   . ASP   A 1 408 ? 6.602   -36.291 -37.883 1.00 32.12  ? 671  ASP   A C   1 
ATOM   2911 O  O   . ASP   A 1 408 ? 5.849   -35.648 -37.177 1.00 34.57  ? 671  ASP   A O   1 
ATOM   2912 C  CB  . ASP   A 1 408 ? 7.271   -36.022 -40.348 1.00 36.07  ? 671  ASP   A CB  1 
ATOM   2913 C  CG  . ASP   A 1 408 ? 7.376   -34.513 -40.378 1.00 32.93  ? 671  ASP   A CG  1 
ATOM   2914 O  OD1 . ASP   A 1 408 ? 7.736   -33.968 -39.324 1.00 35.25  ? 671  ASP   A OD1 1 
ATOM   2915 O  OD2 . ASP   A 1 408 ? 7.005   -33.892 -41.412 1.00 39.44  ? 671  ASP   A OD2 1 
ATOM   2916 N  N   . ASP   A 1 409 ? 7.772   -36.765 -37.458 1.00 33.35  ? 672  ASP   A N   1 
ATOM   2917 C  CA  . ASP   A 1 409 ? 8.144   -36.756 -36.024 1.00 32.63  ? 672  ASP   A CA  1 
ATOM   2918 C  C   . ASP   A 1 409 ? 8.806   -35.441 -35.588 1.00 30.42  ? 672  ASP   A C   1 
ATOM   2919 O  O   . ASP   A 1 409 ? 9.133   -35.329 -34.405 1.00 31.83  ? 672  ASP   A O   1 
ATOM   2920 C  CB  . ASP   A 1 409 ? 8.899   -38.032 -35.691 1.00 35.98  ? 672  ASP   A CB  1 
ATOM   2921 C  CG  . ASP   A 1 409 ? 8.031   -39.263 -35.866 1.00 37.07  ? 672  ASP   A CG  1 
ATOM   2922 O  OD1 . ASP   A 1 409 ? 6.884   -39.258 -35.361 1.00 37.38  ? 672  ASP   A OD1 1 
ATOM   2923 O  OD2 . ASP   A 1 409 ? 8.499   -40.206 -36.510 1.00 39.07  ? 672  ASP   A OD2 1 
ATOM   2924 N  N   . ARG   A 1 410 ? 8.860   -34.392 -36.408 1.00 32.84  ? 673  ARG   A N   1 
ATOM   2925 C  CA  . ARG   A 1 410 ? 9.321   -33.065 -35.890 1.00 31.02  ? 673  ARG   A CA  1 
ATOM   2926 C  C   . ARG   A 1 410 ? 8.399   -32.578 -34.766 1.00 32.36  ? 673  ARG   A C   1 
ATOM   2927 O  O   . ARG   A 1 410 ? 8.859   -31.823 -33.888 1.00 36.03  ? 673  ARG   A O   1 
ATOM   2928 C  CB  . ARG   A 1 410 ? 9.314   -32.021 -37.007 1.00 36.60  ? 673  ARG   A CB  1 
ATOM   2929 C  CG  . ARG   A 1 410 ? 10.431  -32.184 -38.032 1.00 39.49  ? 673  ARG   A CG  1 
ATOM   2930 C  CD  . ARG   A 1 410 ? 10.255  -31.191 -39.157 1.00 37.99  ? 673  ARG   A CD  1 
ATOM   2931 N  NE  . ARG   A 1 410 ? 9.090   -31.543 -39.964 1.00 40.24  ? 673  ARG   A NE  1 
ATOM   2932 C  CZ  . ARG   A 1 410 ? 8.557   -30.771 -40.909 1.00 45.18  ? 673  ARG   A CZ  1 
ATOM   2933 N  NH1 . ARG   A 1 410 ? 9.101   -29.588 -41.174 1.00 40.69  ? 673  ARG   A NH1 1 
ATOM   2934 N  NH2 . ARG   A 1 410 ? 7.503   -31.196 -41.604 1.00 43.85  ? 673  ARG   A NH2 1 
ATOM   2935 N  N   . PHE   A 1 411 ? 7.103   -32.934 -34.833 1.00 33.76  ? 674  PHE   A N   1 
ATOM   2936 C  CA  . PHE   A 1 411 ? 6.068   -32.664 -33.799 1.00 29.57  ? 674  PHE   A CA  1 
ATOM   2937 C  C   . PHE   A 1 411 ? 6.563   -33.025 -32.389 1.00 28.54  ? 674  PHE   A C   1 
ATOM   2938 O  O   . PHE   A 1 411 ? 6.246   -32.273 -31.437 1.00 30.06  ? 674  PHE   A O   1 
ATOM   2939 C  CB  . PHE   A 1 411 ? 4.800   -33.443 -34.179 1.00 34.36  ? 674  PHE   A CB  1 
ATOM   2940 C  CG  . PHE   A 1 411 ? 3.627   -33.313 -33.250 1.00 30.06  ? 674  PHE   A CG  1 
ATOM   2941 C  CD1 . PHE   A 1 411 ? 3.506   -34.132 -32.138 1.00 32.03  ? 674  PHE   A CD1 1 
ATOM   2942 C  CD2 . PHE   A 1 411 ? 2.582   -32.451 -33.558 1.00 33.86  ? 674  PHE   A CD2 1 
ATOM   2943 C  CE1 . PHE   A 1 411 ? 2.379   -34.038 -31.322 1.00 33.87  ? 674  PHE   A CE1 1 
ATOM   2944 C  CE2 . PHE   A 1 411 ? 1.473   -32.344 -32.728 1.00 32.70  ? 674  PHE   A CE2 1 
ATOM   2945 C  CZ  . PHE   A 1 411 ? 1.364   -33.142 -31.611 1.00 28.53  ? 674  PHE   A CZ  1 
ATOM   2946 N  N   . ALA   A 1 412 ? 7.290   -34.143 -32.233 1.00 30.91  ? 675  ALA   A N   1 
ATOM   2947 C  CA  . ALA   A 1 412 ? 7.775   -34.665 -30.929 1.00 30.23  ? 675  ALA   A CA  1 
ATOM   2948 C  C   . ALA   A 1 412 ? 8.524   -33.594 -30.131 1.00 31.23  ? 675  ALA   A C   1 
ATOM   2949 O  O   . ALA   A 1 412 ? 8.357   -33.543 -28.899 1.00 29.72  ? 675  ALA   A O   1 
ATOM   2950 C  CB  . ALA   A 1 412 ? 8.641   -35.880 -31.147 1.00 30.44  ? 675  ALA   A CB  1 
ATOM   2951 N  N   . SER   A 1 413 ? 9.335   -32.768 -30.805 1.00 32.89  ? 676  SER   A N   1 
ATOM   2952 C  CA  . SER   A 1 413 ? 10.182  -31.731 -30.165 1.00 35.67  ? 676  SER   A CA  1 
ATOM   2953 C  C   . SER   A 1 413 ? 9.629   -30.332 -30.431 1.00 35.99  ? 676  SER   A C   1 
ATOM   2954 O  O   . SER   A 1 413 ? 10.274  -29.380 -30.007 1.00 36.57  ? 676  SER   A O   1 
ATOM   2955 C  CB  . SER   A 1 413 ? 11.638  -31.858 -30.598 1.00 37.15  ? 676  SER   A CB  1 
ATOM   2956 O  OG  . SER   A 1 413 ? 11.711  -32.200 -31.981 1.00 41.01  ? 676  SER   A OG  1 
ATOM   2957 N  N   . ALA   A 1 414 ? 8.440   -30.188 -31.017 1.00 36.54  ? 677  ALA   A N   1 
ATOM   2958 C  CA  . ALA   A 1 414 ? 7.811   -28.855 -31.213 1.00 34.98  ? 677  ALA   A CA  1 
ATOM   2959 C  C   . ALA   A 1 414 ? 7.056   -28.481 -29.943 1.00 37.01  ? 677  ALA   A C   1 
ATOM   2960 O  O   . ALA   A 1 414 ? 5.831   -28.785 -29.882 1.00 38.11  ? 677  ALA   A O   1 
ATOM   2961 C  CB  . ALA   A 1 414 ? 6.900   -28.877 -32.413 1.00 35.02  ? 677  ALA   A CB  1 
ATOM   2962 N  N   . LEU   A 1 415 ? 7.729   -27.869 -28.971 1.00 31.48  ? 678  LEU   A N   1 
ATOM   2963 C  CA  . LEU   A 1 415 ? 7.202   -27.701 -27.594 1.00 34.68  ? 678  LEU   A CA  1 
ATOM   2964 C  C   . LEU   A 1 415 ? 7.077   -26.226 -27.175 1.00 38.43  ? 678  LEU   A C   1 
ATOM   2965 O  O   . LEU   A 1 415 ? 6.502   -25.998 -26.095 1.00 44.26  ? 678  LEU   A O   1 
ATOM   2966 C  CB  . LEU   A 1 415 ? 8.078   -28.467 -26.590 1.00 36.62  ? 678  LEU   A CB  1 
ATOM   2967 C  CG  . LEU   A 1 415 ? 8.210   -29.985 -26.800 1.00 36.97  ? 678  LEU   A CG  1 
ATOM   2968 C  CD1 . LEU   A 1 415 ? 9.375   -30.581 -25.981 1.00 38.27  ? 678  LEU   A CD1 1 
ATOM   2969 C  CD2 . LEU   A 1 415 ? 6.920   -30.708 -26.468 1.00 38.59  ? 678  LEU   A CD2 1 
ATOM   2970 N  N   . THR   A 1 416 ? 7.499   -25.241 -27.963 1.00 35.15  ? 679  THR   A N   1 
ATOM   2971 C  CA  . THR   A 1 416 ? 7.583   -23.860 -27.420 1.00 36.46  ? 679  THR   A CA  1 
ATOM   2972 C  C   . THR   A 1 416 ? 6.168   -23.286 -27.284 1.00 33.93  ? 679  THR   A C   1 
ATOM   2973 O  O   . THR   A 1 416 ? 5.835   -22.737 -26.200 1.00 33.76  ? 679  THR   A O   1 
ATOM   2974 C  CB  . THR   A 1 416 ? 8.523   -22.990 -28.251 1.00 40.01  ? 679  THR   A CB  1 
ATOM   2975 O  OG1 . THR   A 1 416 ? 7.986   -22.750 -29.550 1.00 42.53  ? 679  THR   A OG1 1 
ATOM   2976 C  CG2 . THR   A 1 416 ? 9.880   -23.640 -28.425 1.00 42.31  ? 679  THR   A CG2 1 
ATOM   2977 N  N   . ALA   A 1 417 ? 5.346   -23.410 -28.323 1.00 36.17  ? 680  ALA   A N   1 
ATOM   2978 C  CA  . ALA   A 1 417 ? 3.944   -22.903 -28.279 1.00 34.79  ? 680  ALA   A CA  1 
ATOM   2979 C  C   . ALA   A 1 417 ? 3.144   -23.682 -27.229 1.00 37.79  ? 680  ALA   A C   1 
ATOM   2980 O  O   . ALA   A 1 417 ? 2.431   -23.035 -26.405 1.00 39.08  ? 680  ALA   A O   1 
ATOM   2981 C  CB  . ALA   A 1 417 ? 3.319   -22.959 -29.648 1.00 34.46  ? 680  ALA   A CB  1 
ATOM   2982 N  N   . LEU   A 1 418 ? 3.251   -25.020 -27.227 1.00 36.36  ? 681  LEU   A N   1 
ATOM   2983 C  CA  . LEU   A 1 418 ? 2.476   -25.859 -26.272 1.00 34.25  ? 681  LEU   A CA  1 
ATOM   2984 C  C   . LEU   A 1 418 ? 2.827   -25.465 -24.838 1.00 35.58  ? 681  LEU   A C   1 
ATOM   2985 O  O   . LEU   A 1 418 ? 1.886   -25.332 -24.024 1.00 34.42  ? 681  LEU   A O   1 
ATOM   2986 C  CB  . LEU   A 1 418 ? 2.783   -27.334 -26.533 1.00 36.57  ? 681  LEU   A CB  1 
ATOM   2987 C  CG  . LEU   A 1 418 ? 1.919   -28.337 -25.768 1.00 38.37  ? 681  LEU   A CG  1 
ATOM   2988 C  CD1 . LEU   A 1 418 ? 0.536   -28.416 -26.375 1.00 38.21  ? 681  LEU   A CD1 1 
ATOM   2989 C  CD2 . LEU   A 1 418 ? 2.571   -29.706 -25.808 1.00 38.44  ? 681  LEU   A CD2 1 
ATOM   2990 N  N   . ASN   A 1 419 ? 4.129   -25.322 -24.513 1.00 37.21  ? 682  ASN   A N   1 
ATOM   2991 C  CA  . ASN   A 1 419 ? 4.570   -24.926 -23.146 1.00 35.79  ? 682  ASN   A CA  1 
ATOM   2992 C  C   . ASN   A 1 419 ? 4.077   -23.493 -22.874 1.00 37.31  ? 682  ASN   A C   1 
ATOM   2993 O  O   . ASN   A 1 419 ? 3.467   -23.288 -21.818 1.00 38.21  ? 682  ASN   A O   1 
ATOM   2994 C  CB  . ASN   A 1 419 ? 6.080   -25.086 -22.959 1.00 37.28  ? 682  ASN   A CB  1 
ATOM   2995 C  CG  . ASN   A 1 419 ? 6.531   -26.514 -22.685 1.00 37.15  ? 682  ASN   A CG  1 
ATOM   2996 O  OD1 . ASN   A 1 419 ? 5.822   -27.321 -22.075 1.00 40.27  ? 682  ASN   A OD1 1 
ATOM   2997 N  ND2 . ASN   A 1 419 ? 7.705   -26.854 -23.163 1.00 37.39  ? 682  ASN   A ND2 1 
ATOM   2998 N  N   . ASP   A 1 420 ? 4.253   -22.554 -23.816 1.00 35.86  ? 683  ASP   A N   1 
ATOM   2999 C  CA  . ASP   A 1 420 ? 3.907   -21.114 -23.614 1.00 39.37  ? 683  ASP   A CA  1 
ATOM   3000 C  C   . ASP   A 1 420 ? 2.375   -20.902 -23.564 1.00 38.89  ? 683  ASP   A C   1 
ATOM   3001 O  O   . ASP   A 1 420 ? 1.949   -19.985 -22.867 1.00 36.17  ? 683  ASP   A O   1 
ATOM   3002 C  CB  . ASP   A 1 420 ? 4.523   -20.204 -24.689 1.00 39.36  ? 683  ASP   A CB  1 
ATOM   3003 C  CG  . ASP   A 1 420 ? 4.343   -18.718 -24.372 1.00 42.24  ? 683  ASP   A CG  1 
ATOM   3004 O  OD1 . ASP   A 1 420 ? 4.647   -18.321 -23.226 1.00 41.82  ? 683  ASP   A OD1 1 
ATOM   3005 O  OD2 . ASP   A 1 420 ? 3.851   -17.968 -25.266 1.00 37.75  ? 683  ASP   A OD2 1 
ATOM   3006 N  N   . MET   A 1 421 ? 1.557   -21.729 -24.229 1.00 41.69  ? 684  MET   A N   1 
ATOM   3007 C  CA  . MET   A 1 421 ? 0.072   -21.683 -24.050 1.00 40.06  ? 684  MET   A CA  1 
ATOM   3008 C  C   . MET   A 1 421 ? -0.299  -22.170 -22.644 1.00 37.23  ? 684  MET   A C   1 
ATOM   3009 O  O   . MET   A 1 421 ? -1.460  -22.020 -22.272 1.00 36.40  ? 684  MET   A O   1 
ATOM   3010 C  CB  . MET   A 1 421 ? -0.658  -22.514 -25.106 1.00 41.08  ? 684  MET   A CB  1 
ATOM   3011 C  CG  . MET   A 1 421 ? -0.540  -21.911 -26.487 1.00 38.62  ? 684  MET   A CG  1 
ATOM   3012 S  SD  . MET   A 1 421 ? -1.413  -22.871 -27.755 1.00 44.08  ? 684  MET   A SD  1 
ATOM   3013 C  CE  . MET   A 1 421 ? -0.396  -24.335 -27.892 1.00 47.12  ? 684  MET   A CE  1 
ATOM   3014 N  N   . GLY   A 1 422 ? 0.658   -22.713 -21.885 1.00 36.73  ? 685  GLY   A N   1 
ATOM   3015 C  CA  . GLY   A 1 422 ? 0.440   -23.275 -20.533 1.00 32.98  ? 685  GLY   A CA  1 
ATOM   3016 C  C   . GLY   A 1 422 ? -0.058  -24.719 -20.526 1.00 32.48  ? 685  GLY   A C   1 
ATOM   3017 O  O   . GLY   A 1 422 ? -0.348  -25.221 -19.418 1.00 32.60  ? 685  GLY   A O   1 
ATOM   3018 N  N   . LYS   A 1 423 ? -0.154  -25.388 -21.677 1.00 33.16  ? 686  LYS   A N   1 
ATOM   3019 C  CA  . LYS   A 1 423 ? -0.624  -26.811 -21.783 1.00 36.92  ? 686  LYS   A CA  1 
ATOM   3020 C  C   . LYS   A 1 423 ? 0.573   -27.754 -21.568 1.00 40.00  ? 686  LYS   A C   1 
ATOM   3021 O  O   . LYS   A 1 423 ? 0.944   -28.535 -22.497 1.00 39.08  ? 686  LYS   A O   1 
ATOM   3022 C  CB  . LYS   A 1 423 ? -1.368  -27.020 -23.106 1.00 33.34  ? 686  LYS   A CB  1 
ATOM   3023 C  CG  . LYS   A 1 423 ? -2.504  -26.028 -23.310 1.00 33.72  ? 686  LYS   A CG  1 
ATOM   3024 C  CD  . LYS   A 1 423 ? -3.410  -25.968 -22.082 1.00 39.17  ? 686  LYS   A CD  1 
ATOM   3025 C  CE  . LYS   A 1 423 ? -4.581  -25.025 -22.216 1.00 43.84  ? 686  LYS   A CE  1 
ATOM   3026 N  NZ  . LYS   A 1 423 ? -4.138  -23.617 -22.355 1.00 47.02  ? 686  LYS   A NZ  1 
ATOM   3027 N  N   . VAL   A 1 424 ? 1.128   -27.701 -20.352 0.50 39.75  ? 687  VAL   A N   1 
ATOM   3028 C  CA  . VAL   A 1 424 ? 2.347   -28.437 -19.901 0.50 39.34  ? 687  VAL   A CA  1 
ATOM   3029 C  C   . VAL   A 1 424 ? 2.028   -29.933 -19.849 0.50 37.05  ? 687  VAL   A C   1 
ATOM   3030 O  O   . VAL   A 1 424 ? 0.974   -30.290 -19.264 0.50 38.65  ? 687  VAL   A O   1 
ATOM   3031 C  CB  . VAL   A 1 424 ? 2.816   -27.898 -18.533 0.50 41.66  ? 687  VAL   A CB  1 
ATOM   3032 C  CG1 . VAL   A 1 424 ? 3.244   -29.005 -17.581 0.50 42.37  ? 687  VAL   A CG1 1 
ATOM   3033 C  CG2 . VAL   A 1 424 ? 3.921   -26.861 -18.688 0.50 41.37  ? 687  VAL   A CG2 1 
ATOM   3034 N  N   . ARG   A 1 425 ? 2.891   -30.769 -20.438 1.00 34.86  ? 688  ARG   A N   1 
ATOM   3035 C  CA  . ARG   A 1 425 ? 2.651   -32.232 -20.509 1.00 35.77  ? 688  ARG   A CA  1 
ATOM   3036 C  C   . ARG   A 1 425 ? 2.863   -32.848 -19.126 1.00 36.73  ? 688  ARG   A C   1 
ATOM   3037 O  O   . ARG   A 1 425 ? 3.741   -32.355 -18.374 1.00 41.34  ? 688  ARG   A O   1 
ATOM   3038 C  CB  . ARG   A 1 425 ? 3.543   -32.904 -21.549 1.00 32.37  ? 688  ARG   A CB  1 
ATOM   3039 C  CG  . ARG   A 1 425 ? 3.264   -32.441 -22.962 1.00 33.83  ? 688  ARG   A CG  1 
ATOM   3040 C  CD  . ARG   A 1 425 ? 4.381   -32.807 -23.908 1.00 37.20  ? 688  ARG   A CD  1 
ATOM   3041 N  NE  . ARG   A 1 425 ? 5.653   -32.207 -23.512 1.00 40.79  ? 688  ARG   A NE  1 
ATOM   3042 C  CZ  . ARG   A 1 425 ? 6.865   -32.675 -23.837 1.00 37.96  ? 688  ARG   A CZ  1 
ATOM   3043 N  NH1 . ARG   A 1 425 ? 7.016   -33.705 -24.662 1.00 36.70  ? 688  ARG   A NH1 1 
ATOM   3044 N  NH2 . ARG   A 1 425 ? 7.931   -32.049 -23.375 1.00 42.56  ? 688  ARG   A NH2 1 
ATOM   3045 N  N   . LYS   A 1 426 ? 2.092   -33.904 -18.842 0.50 37.08  ? 689  LYS   A N   1 
ATOM   3046 C  CA  . LYS   A 1 426 ? 2.142   -34.752 -17.620 0.50 39.83  ? 689  LYS   A CA  1 
ATOM   3047 C  C   . LYS   A 1 426 ? 3.438   -35.588 -17.604 0.50 41.76  ? 689  LYS   A C   1 
ATOM   3048 O  O   . LYS   A 1 426 ? 3.898   -36.015 -18.690 0.50 37.62  ? 689  LYS   A O   1 
ATOM   3049 C  CB  . LYS   A 1 426 ? 0.902   -35.655 -17.624 0.50 41.77  ? 689  LYS   A CB  1 
ATOM   3050 C  CG  . LYS   A 1 426 ? 0.529   -36.314 -16.303 0.50 42.88  ? 689  LYS   A CG  1 
ATOM   3051 C  CD  . LYS   A 1 426 ? -0.353  -37.529 -16.492 0.50 45.92  ? 689  LYS   A CD  1 
ATOM   3052 C  CE  . LYS   A 1 426 ? 0.252   -38.542 -17.448 0.50 47.50  ? 689  LYS   A CE  1 
ATOM   3053 N  NZ  . LYS   A 1 426 ? -0.687  -39.646 -17.762 0.50 46.99  ? 689  LYS   A NZ  1 
ATOM   3054 N  N   . ASP   A 1 427 ? 4.004   -35.807 -16.411 0.50 43.79  ? 690  ASP   A N   1 
ATOM   3055 C  CA  . ASP   A 1 427 ? 5.103   -36.777 -16.136 0.50 46.71  ? 690  ASP   A CA  1 
ATOM   3056 C  C   . ASP   A 1 427 ? 6.011   -36.936 -17.369 0.50 46.45  ? 690  ASP   A C   1 
ATOM   3057 O  O   . ASP   A 1 427 ? 6.051   -38.036 -17.953 0.50 48.66  ? 690  ASP   A O   1 
ATOM   3058 C  CB  . ASP   A 1 427 ? 4.519   -38.099 -15.638 0.50 48.33  ? 690  ASP   A CB  1 
ATOM   3059 C  CG  . ASP   A 1 427 ? 3.881   -37.974 -14.265 0.50 50.82  ? 690  ASP   A CG  1 
ATOM   3060 O  OD1 . ASP   A 1 427 ? 4.153   -36.968 -13.580 0.50 50.61  ? 690  ASP   A OD1 1 
ATOM   3061 O  OD2 . ASP   A 1 427 ? 3.110   -38.880 -13.895 0.50 59.58  ? 690  ASP   A OD2 1 
ATOM   3062 N  N   . ILE   A 1 428 ? 6.670   -35.836 -17.743 1.00 46.06  ? 691  ILE   A N   1 
ATOM   3063 C  CA  . ILE   A 1 428 ? 7.824   -35.750 -18.689 1.00 46.75  ? 691  ILE   A CA  1 
ATOM   3064 C  C   . ILE   A 1 428 ? 8.401   -34.355 -18.487 1.00 47.50  ? 691  ILE   A C   1 
ATOM   3065 O  O   . ILE   A 1 428 ? 7.645   -33.449 -18.189 1.00 50.96  ? 691  ILE   A O   1 
ATOM   3066 C  CB  . ILE   A 1 428 ? 7.427   -36.022 -20.155 1.00 49.91  ? 691  ILE   A CB  1 
ATOM   3067 C  CG1 . ILE   A 1 428 ? 8.683   -36.150 -21.019 1.00 49.13  ? 691  ILE   A CG1 1 
ATOM   3068 C  CG2 . ILE   A 1 428 ? 6.500   -34.955 -20.700 1.00 48.99  ? 691  ILE   A CG2 1 
ATOM   3069 C  CD1 . ILE   A 1 428 ? 8.454   -36.668 -22.414 1.00 44.04  ? 691  ILE   A CD1 1 
ATOM   3070 N  N   . GLN   A 1 429 ? 9.725   -34.191 -18.607 0.50 48.84  ? 692  GLN   A N   1 
ATOM   3071 C  CA  . GLN   A 1 429 ? 10.413  -32.887 -18.382 0.50 47.89  ? 692  GLN   A CA  1 
ATOM   3072 C  C   . GLN   A 1 429 ? 10.014  -31.911 -19.495 0.50 45.23  ? 692  GLN   A C   1 
ATOM   3073 O  O   . GLN   A 1 429 ? 9.837   -32.352 -20.647 0.50 41.40  ? 692  GLN   A O   1 
ATOM   3074 C  CB  . GLN   A 1 429 ? 11.933  -33.054 -18.314 0.50 52.63  ? 692  GLN   A CB  1 
ATOM   3075 C  CG  . GLN   A 1 429 ? 12.461  -33.348 -16.913 0.50 56.25  ? 692  GLN   A CG  1 
ATOM   3076 C  CD  . GLN   A 1 429 ? 13.945  -33.631 -16.896 0.50 55.99  ? 692  GLN   A CD  1 
ATOM   3077 O  OE1 . GLN   A 1 429 ? 14.577  -33.809 -17.939 0.50 56.76  ? 692  GLN   A OE1 1 
ATOM   3078 N  NE2 . GLN   A 1 429 ? 14.514  -33.690 -15.702 0.50 54.91  ? 692  GLN   A NE2 1 
ATOM   3079 N  N   . GLN   A 1 430 ? 9.918   -30.625 -19.153 0.50 46.83  ? 693  GLN   A N   1 
ATOM   3080 C  CA  . GLN   A 1 430 ? 9.262   -29.576 -19.975 0.50 47.75  ? 693  GLN   A CA  1 
ATOM   3081 C  C   . GLN   A 1 430 ? 9.802   -29.597 -21.407 0.50 46.96  ? 693  GLN   A C   1 
ATOM   3082 O  O   . GLN   A 1 430 ? 8.985   -29.386 -22.327 0.50 45.63  ? 693  GLN   A O   1 
ATOM   3083 C  CB  . GLN   A 1 430 ? 9.448   -28.185 -19.366 0.50 48.33  ? 693  GLN   A CB  1 
ATOM   3084 C  CG  . GLN   A 1 430 ? 8.200   -27.326 -19.511 0.50 48.27  ? 693  GLN   A CG  1 
ATOM   3085 C  CD  . GLN   A 1 430 ? 8.479   -25.844 -19.508 0.50 48.30  ? 693  GLN   A CD  1 
ATOM   3086 O  OE1 . GLN   A 1 430 ? 9.630   -25.408 -19.531 0.50 49.09  ? 693  GLN   A OE1 1 
ATOM   3087 N  NE2 . GLN   A 1 430 ? 7.414   -25.056 -19.478 0.50 44.95  ? 693  GLN   A NE2 1 
ATOM   3088 N  N   . TRP   A 1 431 ? 11.111  -29.825 -21.581 1.00 45.95  ? 694  TRP   A N   1 
ATOM   3089 C  CA  . TRP   A 1 431 ? 11.791  -29.714 -22.906 1.00 44.10  ? 694  TRP   A CA  1 
ATOM   3090 C  C   . TRP   A 1 431 ? 12.232  -31.075 -23.460 1.00 41.88  ? 694  TRP   A C   1 
ATOM   3091 O  O   . TRP   A 1 431 ? 12.848  -31.090 -24.529 1.00 42.56  ? 694  TRP   A O   1 
ATOM   3092 C  CB  . TRP   A 1 431 ? 12.925  -28.681 -22.819 1.00 53.27  ? 694  TRP   A CB  1 
ATOM   3093 C  CG  . TRP   A 1 431 ? 12.420  -27.344 -22.347 1.00 59.10  ? 694  TRP   A CG  1 
ATOM   3094 C  CD1 . TRP   A 1 431 ? 12.653  -26.749 -21.141 1.00 56.45  ? 694  TRP   A CD1 1 
ATOM   3095 C  CD2 . TRP   A 1 431 ? 11.505  -26.475 -23.048 1.00 58.66  ? 694  TRP   A CD2 1 
ATOM   3096 N  NE1 . TRP   A 1 431 ? 11.974  -25.559 -21.061 1.00 62.95  ? 694  TRP   A NE1 1 
ATOM   3097 C  CE2 . TRP   A 1 431 ? 11.267  -25.362 -22.215 1.00 59.03  ? 694  TRP   A CE2 1 
ATOM   3098 C  CE3 . TRP   A 1 431 ? 10.893  -26.515 -24.307 1.00 52.70  ? 694  TRP   A CE3 1 
ATOM   3099 C  CZ2 . TRP   A 1 431 ? 10.406  -24.331 -22.584 1.00 56.91  ? 694  TRP   A CZ2 1 
ATOM   3100 C  CZ3 . TRP   A 1 431 ? 10.076  -25.475 -24.689 1.00 54.39  ? 694  TRP   A CZ3 1 
ATOM   3101 C  CH2 . TRP   A 1 431 ? 9.831   -24.404 -23.833 1.00 56.45  ? 694  TRP   A CH2 1 
ATOM   3102 N  N   . GLU   A 1 432 ? 11.790  -32.174 -22.851 1.00 42.32  ? 695  GLU   A N   1 
ATOM   3103 C  CA  . GLU   A 1 432 ? 12.093  -33.549 -23.316 1.00 45.92  ? 695  GLU   A CA  1 
ATOM   3104 C  C   . GLU   A 1 432 ? 11.114  -33.883 -24.458 1.00 42.65  ? 695  GLU   A C   1 
ATOM   3105 O  O   . GLU   A 1 432 ? 9.902   -33.736 -24.343 1.00 33.33  ? 695  GLU   A O   1 
ATOM   3106 C  CB  . GLU   A 1 432 ? 12.096  -34.438 -22.059 1.00 49.01  ? 695  GLU   A CB  1 
ATOM   3107 C  CG  . GLU   A 1 432 ? 12.604  -35.855 -22.265 1.00 58.00  ? 695  GLU   A CG  1 
ATOM   3108 C  CD  . GLU   A 1 432 ? 14.057  -36.001 -22.724 1.00 69.74  ? 695  GLU   A CD  1 
ATOM   3109 O  OE1 . GLU   A 1 432 ? 14.342  -37.029 -23.421 1.00 63.10  ? 695  GLU   A OE1 1 
ATOM   3110 O  OE2 . GLU   A 1 432 ? 14.914  -35.101 -22.392 1.00 66.08  ? 695  GLU   A OE2 1 
ATOM   3111 N  N   . PRO   A 1 433 ? 11.586  -34.313 -25.640 1.00 39.81  ? 696  PRO   A N   1 
ATOM   3112 C  CA  . PRO   A 1 433 ? 10.677  -34.642 -26.739 1.00 35.44  ? 696  PRO   A CA  1 
ATOM   3113 C  C   . PRO   A 1 433 ? 9.646   -35.706 -26.355 1.00 36.31  ? 696  PRO   A C   1 
ATOM   3114 O  O   . PRO   A 1 433 ? 9.946   -36.507 -25.550 1.00 34.13  ? 696  PRO   A O   1 
ATOM   3115 C  CB  . PRO   A 1 433 ? 11.573  -35.203 -27.853 1.00 40.82  ? 696  PRO   A CB  1 
ATOM   3116 C  CG  . PRO   A 1 433 ? 12.999  -34.692 -27.485 1.00 42.82  ? 696  PRO   A CG  1 
ATOM   3117 C  CD  . PRO   A 1 433 ? 12.999  -34.547 -25.976 1.00 40.97  ? 696  PRO   A CD  1 
ATOM   3118 N  N   . SER   A 1 434 ? 8.461   -35.670 -26.969 1.00 33.07  ? 697  SER   A N   1 
ATOM   3119 C  CA  . SER   A 1 434 ? 7.347   -36.597 -26.703 1.00 32.83  ? 697  SER   A CA  1 
ATOM   3120 C  C   . SER   A 1 434 ? 7.759   -37.978 -27.201 1.00 32.56  ? 697  SER   A C   1 
ATOM   3121 O  O   . SER   A 1 434 ? 8.377   -38.037 -28.245 1.00 38.87  ? 697  SER   A O   1 
ATOM   3122 C  CB  . SER   A 1 434 ? 6.078   -36.133 -27.415 1.00 30.88  ? 697  SER   A CB  1 
ATOM   3123 O  OG  . SER   A 1 434 ? 5.541   -35.002 -26.787 1.00 29.85  ? 697  SER   A OG  1 
ATOM   3124 N  N   . ARG   A 1 435 ? 7.369   -39.032 -26.509 1.00 33.89  ? 698  ARG   A N   1 
ATOM   3125 C  CA  . ARG   A 1 435 ? 7.536   -40.431 -26.962 1.00 41.76  ? 698  ARG   A CA  1 
ATOM   3126 C  C   . ARG   A 1 435 ? 6.213   -40.838 -27.609 1.00 45.47  ? 698  ARG   A C   1 
ATOM   3127 O  O   . ARG   A 1 435 ? 5.189   -40.845 -26.910 1.00 46.44  ? 698  ARG   A O   1 
ATOM   3128 C  CB  . ARG   A 1 435 ? 7.906   -41.329 -25.775 1.00 52.09  ? 698  ARG   A CB  1 
ATOM   3129 C  CG  . ARG   A 1 435 ? 9.357   -41.169 -25.319 1.00 61.93  ? 698  ARG   A CG  1 
ATOM   3130 C  CD  . ARG   A 1 435 ? 9.695   -41.917 -24.033 1.00 78.25  ? 698  ARG   A CD  1 
ATOM   3131 N  NE  . ARG   A 1 435 ? 8.846   -41.526 -22.900 1.00 93.62  ? 698  ARG   A NE  1 
ATOM   3132 C  CZ  . ARG   A 1 435 ? 9.114   -40.560 -22.004 1.00 99.93  ? 698  ARG   A CZ  1 
ATOM   3133 N  NH1 . ARG   A 1 435 ? 10.230  -39.845 -22.065 1.00 101.78 ? 698  ARG   A NH1 1 
ATOM   3134 N  NH2 . ARG   A 1 435 ? 8.248   -40.311 -21.035 1.00 89.82  ? 698  ARG   A NH2 1 
ATOM   3135 N  N   . GLY   A 1 436 ? 6.242   -41.128 -28.899 1.00 36.50  ? 699  GLY   A N   1 
ATOM   3136 C  CA  . GLY   A 1 436 ? 5.064   -41.517 -29.675 1.00 41.41  ? 699  GLY   A CA  1 
ATOM   3137 C  C   . GLY   A 1 436 ? 4.894   -43.023 -29.730 1.00 37.52  ? 699  GLY   A C   1 
ATOM   3138 O  O   . GLY   A 1 436 ? 5.786   -43.733 -29.361 1.00 37.15  ? 699  GLY   A O   1 
ATOM   3139 N  N   . TRP   A 1 437 ? 3.749   -43.468 -30.217 1.00 34.04  ? 700  TRP   A N   1 
ATOM   3140 C  CA  . TRP   A 1 437 ? 3.388   -44.884 -30.322 1.00 29.87  ? 700  TRP   A CA  1 
ATOM   3141 C  C   . TRP   A 1 437 ? 3.499   -45.263 -31.787 1.00 30.40  ? 700  TRP   A C   1 
ATOM   3142 O  O   . TRP   A 1 437 ? 3.041   -44.484 -32.649 1.00 31.15  ? 700  TRP   A O   1 
ATOM   3143 C  CB  . TRP   A 1 437 ? 1.977   -45.091 -29.790 1.00 31.88  ? 700  TRP   A CB  1 
ATOM   3144 C  CG  . TRP   A 1 437 ? 1.792   -44.636 -28.382 1.00 29.01  ? 700  TRP   A CG  1 
ATOM   3145 C  CD1 . TRP   A 1 437 ? 1.486   -43.387 -27.931 1.00 29.29  ? 700  TRP   A CD1 1 
ATOM   3146 C  CD2 . TRP   A 1 437 ? 1.951   -45.450 -27.220 1.00 25.42  ? 700  TRP   A CD2 1 
ATOM   3147 N  NE1 . TRP   A 1 437 ? 1.460   -43.368 -26.565 1.00 26.51  ? 700  TRP   A NE1 1 
ATOM   3148 C  CE2 . TRP   A 1 437 ? 1.681   -44.636 -26.108 1.00 27.90  ? 700  TRP   A CE2 1 
ATOM   3149 C  CE3 . TRP   A 1 437 ? 2.286   -46.771 -27.041 1.00 26.25  ? 700  TRP   A CE3 1 
ATOM   3150 C  CZ2 . TRP   A 1 437 ? 1.747   -45.116 -24.812 1.00 28.45  ? 700  TRP   A CZ2 1 
ATOM   3151 C  CZ3 . TRP   A 1 437 ? 2.354   -47.250 -25.768 1.00 29.02  ? 700  TRP   A CZ3 1 
ATOM   3152 C  CH2 . TRP   A 1 437 ? 2.093   -46.433 -24.674 1.00 28.00  ? 700  TRP   A CH2 1 
ATOM   3153 N  N   . ASN   A 1 438 ? 4.067   -46.418 -32.044 1.00 29.74  ? 701  ASN   A N   1 
ATOM   3154 C  CA  . ASN   A 1 438 ? 4.249   -46.956 -33.405 1.00 35.01  ? 701  ASN   A CA  1 
ATOM   3155 C  C   . ASN   A 1 438 ? 3.037   -47.765 -33.830 1.00 36.70  ? 701  ASN   A C   1 
ATOM   3156 O  O   . ASN   A 1 438 ? 2.937   -48.006 -35.025 1.00 37.83  ? 701  ASN   A O   1 
ATOM   3157 C  CB  . ASN   A 1 438 ? 5.492   -47.855 -33.452 1.00 42.46  ? 701  ASN   A CB  1 
ATOM   3158 C  CG  . ASN   A 1 438 ? 6.754   -47.058 -33.173 1.00 52.48  ? 701  ASN   A CG  1 
ATOM   3159 O  OD1 . ASN   A 1 438 ? 7.559   -47.419 -32.292 1.00 58.65  ? 701  ASN   A OD1 1 
ATOM   3160 N  ND2 . ASN   A 1 438 ? 6.885   -45.937 -33.886 1.00 42.04  ? 701  ASN   A ND2 1 
ATOM   3161 N  N   . ASP   A 1 439 ? 2.206   -48.225 -32.895 1.00 36.56  ? 702  ASP   A N   1 
ATOM   3162 C  CA  . ASP   A 1 439 ? 1.113   -49.182 -33.210 1.00 40.95  ? 702  ASP   A CA  1 
ATOM   3163 C  C   . ASP   A 1 439 ? -0.182  -48.595 -32.628 1.00 36.71  ? 702  ASP   A C   1 
ATOM   3164 O  O   . ASP   A 1 439 ? -0.220  -48.323 -31.425 1.00 37.01  ? 702  ASP   A O   1 
ATOM   3165 C  CB  . ASP   A 1 439 ? 1.575   -50.569 -32.722 1.00 42.38  ? 702  ASP   A CB  1 
ATOM   3166 C  CG  . ASP   A 1 439 ? 0.544   -51.690 -32.689 1.00 50.45  ? 702  ASP   A CG  1 
ATOM   3167 O  OD1 . ASP   A 1 439 ? -0.564  -51.507 -33.269 1.00 45.24  ? 702  ASP   A OD1 1 
ATOM   3168 O  OD2 . ASP   A 1 439 ? 0.875   -52.771 -32.081 1.00 53.52  ? 702  ASP   A OD2 1 
ATOM   3169 N  N   . TRP   A 1 440 ? -1.212  -48.410 -33.449 1.00 34.19  ? 703  TRP   A N   1 
ATOM   3170 C  CA  . TRP   A 1 440 ? -2.497  -47.826 -33.012 1.00 30.88  ? 703  TRP   A CA  1 
ATOM   3171 C  C   . TRP   A 1 440 ? -3.136  -48.683 -31.910 1.00 29.74  ? 703  TRP   A C   1 
ATOM   3172 O  O   . TRP   A 1 440 ? -3.863  -48.118 -31.088 1.00 32.78  ? 703  TRP   A O   1 
ATOM   3173 C  CB  . TRP   A 1 440 ? -3.415  -47.584 -34.206 1.00 32.61  ? 703  TRP   A CB  1 
ATOM   3174 C  CG  . TRP   A 1 440 ? -3.939  -48.830 -34.853 1.00 35.71  ? 703  TRP   A CG  1 
ATOM   3175 C  CD1 . TRP   A 1 440 ? -3.391  -49.499 -35.905 1.00 37.80  ? 703  TRP   A CD1 1 
ATOM   3176 C  CD2 . TRP   A 1 440 ? -5.118  -49.562 -34.501 1.00 33.88  ? 703  TRP   A CD2 1 
ATOM   3177 N  NE1 . TRP   A 1 440 ? -4.172  -50.563 -36.260 1.00 34.55  ? 703  TRP   A NE1 1 
ATOM   3178 C  CE2 . TRP   A 1 440 ? -5.207  -50.667 -35.383 1.00 37.06  ? 703  TRP   A CE2 1 
ATOM   3179 C  CE3 . TRP   A 1 440 ? -6.113  -49.389 -33.545 1.00 32.15  ? 703  TRP   A CE3 1 
ATOM   3180 C  CZ2 . TRP   A 1 440 ? -6.244  -51.608 -35.332 1.00 34.08  ? 703  TRP   A CZ2 1 
ATOM   3181 C  CZ3 . TRP   A 1 440 ? -7.132  -50.317 -33.491 1.00 31.78  ? 703  TRP   A CZ3 1 
ATOM   3182 C  CH2 . TRP   A 1 440 ? -7.195  -51.401 -34.371 1.00 33.43  ? 703  TRP   A CH2 1 
ATOM   3183 N  N   . THR   A 1 441 ? -2.808  -49.966 -31.809 1.00 30.93  ? 704  THR   A N   1 
ATOM   3184 C  CA  . THR   A 1 441 ? -3.370  -50.875 -30.768 1.00 31.47  ? 704  THR   A CA  1 
ATOM   3185 C  C   . THR   A 1 441 ? -2.754  -50.669 -29.373 1.00 30.26  ? 704  THR   A C   1 
ATOM   3186 O  O   . THR   A 1 441 ? -3.241  -51.282 -28.427 1.00 32.47  ? 704  THR   A O   1 
ATOM   3187 C  CB  . THR   A 1 441 ? -3.350  -52.349 -31.211 1.00 30.03  ? 704  THR   A CB  1 
ATOM   3188 O  OG1 . THR   A 1 441 ? -2.015  -52.827 -31.239 1.00 30.75  ? 704  THR   A OG1 1 
ATOM   3189 C  CG2 . THR   A 1 441 ? -3.976  -52.586 -32.576 1.00 30.41  ? 704  THR   A CG2 1 
ATOM   3190 N  N   . GLN   A 1 442 ? -1.737  -49.812 -29.239 0.50 30.24  ? 705  GLN   A N   1 
ATOM   3191 C  CA  . GLN   A 1 442 ? -1.073  -49.505 -27.941 0.50 30.64  ? 705  GLN   A CA  1 
ATOM   3192 C  C   . GLN   A 1 442 ? -1.354  -48.069 -27.481 0.50 27.46  ? 705  GLN   A C   1 
ATOM   3193 O  O   . GLN   A 1 442 ? -0.960  -47.732 -26.358 0.50 25.40  ? 705  GLN   A O   1 
ATOM   3194 C  CB  . GLN   A 1 442 ? 0.434   -49.690 -28.095 0.50 32.48  ? 705  GLN   A CB  1 
ATOM   3195 C  CG  . GLN   A 1 442 ? 0.775   -50.897 -28.943 0.50 34.22  ? 705  GLN   A CG  1 
ATOM   3196 C  CD  . GLN   A 1 442 ? 0.615   -52.146 -28.124 0.50 35.42  ? 705  GLN   A CD  1 
ATOM   3197 O  OE1 . GLN   A 1 442 ? 1.210   -52.261 -27.052 0.50 37.00  ? 705  GLN   A OE1 1 
ATOM   3198 N  NE2 . GLN   A 1 442 ? -0.194  -53.074 -28.621 0.50 34.78  ? 705  GLN   A NE2 1 
ATOM   3199 N  N   . VAL   A 1 443 ? -1.960  -47.242 -28.330 1.00 28.36  ? 706  VAL   A N   1 
ATOM   3200 C  CA  . VAL   A 1 443 ? -2.274  -45.821 -27.991 1.00 30.83  ? 706  VAL   A CA  1 
ATOM   3201 C  C   . VAL   A 1 443 ? -3.334  -45.781 -26.895 1.00 26.49  ? 706  VAL   A C   1 
ATOM   3202 O  O   . VAL   A 1 443 ? -4.356  -46.429 -27.007 1.00 29.14  ? 706  VAL   A O   1 
ATOM   3203 C  CB  . VAL   A 1 443 ? -2.731  -45.042 -29.235 1.00 33.08  ? 706  VAL   A CB  1 
ATOM   3204 C  CG1 . VAL   A 1 443 ? -3.078  -43.588 -28.926 1.00 39.39  ? 706  VAL   A CG1 1 
ATOM   3205 C  CG2 . VAL   A 1 443 ? -1.665  -45.084 -30.299 1.00 37.18  ? 706  VAL   A CG2 1 
ATOM   3206 N  N   . PRO   A 1 444 ? -3.111  -45.034 -25.795 1.00 26.02  ? 707  PRO   A N   1 
ATOM   3207 C  CA  . PRO   A 1 444 ? -4.167  -44.801 -24.817 1.00 25.83  ? 707  PRO   A CA  1 
ATOM   3208 C  C   . PRO   A 1 444 ? -5.114  -43.695 -25.307 1.00 28.78  ? 707  PRO   A C   1 
ATOM   3209 O  O   . PRO   A 1 444 ? -4.644  -42.705 -25.812 1.00 28.60  ? 707  PRO   A O   1 
ATOM   3210 C  CB  . PRO   A 1 444 ? -3.403  -44.368 -23.576 1.00 28.22  ? 707  PRO   A CB  1 
ATOM   3211 C  CG  . PRO   A 1 444 ? -2.137  -43.677 -24.138 1.00 31.41  ? 707  PRO   A CG  1 
ATOM   3212 C  CD  . PRO   A 1 444 ? -1.848  -44.339 -25.475 1.00 28.99  ? 707  PRO   A CD  1 
ATOM   3213 N  N   . PHE   A 1 445 ? -6.429  -43.880 -25.164 1.00 26.36  ? 708  PHE   A N   1 
ATOM   3214 C  CA  . PHE   A 1 445 ? -7.422  -42.824 -25.469 1.00 26.03  ? 708  PHE   A CA  1 
ATOM   3215 C  C   . PHE   A 1 445 ? -8.684  -43.090 -24.650 1.00 24.51  ? 708  PHE   A C   1 
ATOM   3216 O  O   . PHE   A 1 445 ? -9.135  -44.220 -24.702 1.00 22.39  ? 708  PHE   A O   1 
ATOM   3217 C  CB  . PHE   A 1 445 ? -7.753  -42.845 -26.966 1.00 27.57  ? 708  PHE   A CB  1 
ATOM   3218 C  CG  . PHE   A 1 445 ? -8.616  -41.696 -27.437 1.00 27.31  ? 708  PHE   A CG  1 
ATOM   3219 C  CD1 . PHE   A 1 445 ? -8.302  -40.382 -27.104 1.00 29.72  ? 708  PHE   A CD1 1 
ATOM   3220 C  CD2 . PHE   A 1 445 ? -9.705  -41.913 -28.257 1.00 27.98  ? 708  PHE   A CD2 1 
ATOM   3221 C  CE1 . PHE   A 1 445 ? -9.076  -39.320 -27.550 1.00 29.75  ? 708  PHE   A CE1 1 
ATOM   3222 C  CE2 . PHE   A 1 445 ? -10.445 -40.848 -28.757 1.00 29.79  ? 708  PHE   A CE2 1 
ATOM   3223 C  CZ  . PHE   A 1 445 ? -10.166 -39.557 -28.355 1.00 30.02  ? 708  PHE   A CZ  1 
ATOM   3224 N  N   . CYS   A 1 446 ? -9.202  -42.086 -23.950 1.00 26.21  ? 709  CYS   A N   1 
ATOM   3225 C  CA  . CYS   A 1 446 ? -10.438 -42.135 -23.100 1.00 26.35  ? 709  CYS   A CA  1 
ATOM   3226 C  C   . CYS   A 1 446 ? -10.360 -43.338 -22.160 1.00 26.68  ? 709  CYS   A C   1 
ATOM   3227 O  O   . CYS   A 1 446 ? -11.352 -44.117 -22.099 1.00 26.98  ? 709  CYS   A O   1 
ATOM   3228 C  CB  . CYS   A 1 446 ? -11.666 -42.192 -23.989 1.00 27.49  ? 709  CYS   A CB  1 
ATOM   3229 S  SG  . CYS   A 1 446 ? -11.786 -40.740 -25.080 1.00 32.74  ? 709  CYS   A SG  1 
ATOM   3230 N  N   . SER   A 1 447 ? -9.162  -43.578 -21.595 1.00 25.58  ? 710  SER   A N   1 
ATOM   3231 C  CA  . SER   A 1 447 ? -8.903  -44.580 -20.534 1.00 25.58  ? 710  SER   A CA  1 
ATOM   3232 C  C   . SER   A 1 447 ? -8.933  -46.003 -21.118 1.00 27.07  ? 710  SER   A C   1 
ATOM   3233 O  O   . SER   A 1 447 ? -9.041  -46.974 -20.337 1.00 26.80  ? 710  SER   A O   1 
ATOM   3234 C  CB  . SER   A 1 447 ? -9.926  -44.476 -19.437 1.00 31.89  ? 710  SER   A CB  1 
ATOM   3235 O  OG  . SER   A 1 447 ? -9.943  -43.188 -18.862 1.00 36.30  ? 710  SER   A OG  1 
ATOM   3236 N  N   . HIS   A 1 448 ? -8.839  -46.143 -22.429 1.00 25.72  ? 711  HIS   A N   1 
ATOM   3237 C  CA  . HIS   A 1 448 ? -8.863  -47.455 -23.111 1.00 23.99  ? 711  HIS   A CA  1 
ATOM   3238 C  C   . HIS   A 1 448 ? -7.627  -47.653 -24.002 1.00 23.86  ? 711  HIS   A C   1 
ATOM   3239 O  O   . HIS   A 1 448 ? -6.958  -46.659 -24.347 1.00 19.75  ? 711  HIS   A O   1 
ATOM   3240 C  CB  . HIS   A 1 448 ? -10.149 -47.550 -23.932 1.00 25.22  ? 711  HIS   A CB  1 
ATOM   3241 C  CG  . HIS   A 1 448 ? -11.338 -47.794 -23.072 1.00 25.08  ? 711  HIS   A CG  1 
ATOM   3242 N  ND1 . HIS   A 1 448 ? -11.888 -46.796 -22.272 1.00 26.76  ? 711  HIS   A ND1 1 
ATOM   3243 C  CD2 . HIS   A 1 448 ? -12.013 -48.928 -22.818 1.00 27.49  ? 711  HIS   A CD2 1 
ATOM   3244 C  CE1 . HIS   A 1 448 ? -12.886 -47.315 -21.589 1.00 28.66  ? 711  HIS   A CE1 1 
ATOM   3245 N  NE2 . HIS   A 1 448 ? -12.999 -48.643 -21.908 1.00 26.88  ? 711  HIS   A NE2 1 
ATOM   3246 N  N   . HIS   A 1 449 ? -7.404  -48.898 -24.418 1.00 22.38  ? 712  HIS   A N   1 
ATOM   3247 C  CA  . HIS   A 1 449 ? -6.684  -49.246 -25.673 1.00 25.23  ? 712  HIS   A CA  1 
ATOM   3248 C  C   . HIS   A 1 449 ? -7.614  -50.136 -26.488 1.00 24.26  ? 712  HIS   A C   1 
ATOM   3249 O  O   . HIS   A 1 449 ? -8.677  -50.488 -25.993 1.00 24.23  ? 712  HIS   A O   1 
ATOM   3250 C  CB  . HIS   A 1 449 ? -5.360  -49.949 -25.408 1.00 22.08  ? 712  HIS   A CB  1 
ATOM   3251 C  CG  . HIS   A 1 449 ? -5.547  -51.163 -24.557 1.00 21.99  ? 712  HIS   A CG  1 
ATOM   3252 N  ND1 . HIS   A 1 449 ? -5.689  -51.080 -23.197 1.00 22.22  ? 712  HIS   A ND1 1 
ATOM   3253 C  CD2 . HIS   A 1 449 ? -5.661  -52.471 -24.857 1.00 21.74  ? 712  HIS   A CD2 1 
ATOM   3254 C  CE1 . HIS   A 1 449 ? -5.880  -52.289 -22.696 1.00 22.24  ? 712  HIS   A CE1 1 
ATOM   3255 N  NE2 . HIS   A 1 449 ? -5.906  -53.143 -23.689 1.00 21.26  ? 712  HIS   A NE2 1 
ATOM   3256 N  N   . PHE   A 1 450 ? -7.225  -50.432 -27.709 1.00 23.83  ? 713  PHE   A N   1 
ATOM   3257 C  CA  . PHE   A 1 450 ? -8.121  -51.073 -28.684 1.00 25.57  ? 713  PHE   A CA  1 
ATOM   3258 C  C   . PHE   A 1 450 ? -7.397  -52.247 -29.323 1.00 25.46  ? 713  PHE   A C   1 
ATOM   3259 O  O   . PHE   A 1 450 ? -6.221  -52.103 -29.755 1.00 26.91  ? 713  PHE   A O   1 
ATOM   3260 C  CB  . PHE   A 1 450 ? -8.612  -50.035 -29.694 1.00 25.03  ? 713  PHE   A CB  1 
ATOM   3261 C  CG  . PHE   A 1 450 ? -9.352  -48.924 -29.000 1.00 27.62  ? 713  PHE   A CG  1 
ATOM   3262 C  CD1 . PHE   A 1 450 ? -8.661  -47.875 -28.412 1.00 26.19  ? 713  PHE   A CD1 1 
ATOM   3263 C  CD2 . PHE   A 1 450 ? -10.719 -49.000 -28.820 1.00 27.53  ? 713  PHE   A CD2 1 
ATOM   3264 C  CE1 . PHE   A 1 450 ? -9.342  -46.884 -27.720 1.00 26.10  ? 713  PHE   A CE1 1 
ATOM   3265 C  CE2 . PHE   A 1 450 ? -11.405 -48.012 -28.111 1.00 29.04  ? 713  PHE   A CE2 1 
ATOM   3266 C  CZ  . PHE   A 1 450 ? -10.712 -46.957 -27.559 1.00 27.04  ? 713  PHE   A CZ  1 
ATOM   3267 N  N   . HIS   A 1 451 ? -8.114  -53.365 -29.422 1.00 26.12  ? 714  HIS   A N   1 
ATOM   3268 C  CA  . HIS   A 1 451 ? -7.609  -54.602 -30.045 1.00 26.73  ? 714  HIS   A CA  1 
ATOM   3269 C  C   . HIS   A 1 451 ? -8.296  -54.794 -31.394 1.00 28.31  ? 714  HIS   A C   1 
ATOM   3270 O  O   . HIS   A 1 451 ? -9.463  -54.420 -31.533 1.00 28.35  ? 714  HIS   A O   1 
ATOM   3271 C  CB  . HIS   A 1 451 ? -7.812  -55.780 -29.100 1.00 25.35  ? 714  HIS   A CB  1 
ATOM   3272 C  CG  . HIS   A 1 451 ? -7.056  -55.762 -27.801 1.00 24.43  ? 714  HIS   A CG  1 
ATOM   3273 N  ND1 . HIS   A 1 451 ? -5.984  -56.581 -27.563 1.00 26.75  ? 714  HIS   A ND1 1 
ATOM   3274 C  CD2 . HIS   A 1 451 ? -7.327  -55.157 -26.619 1.00 26.06  ? 714  HIS   A CD2 1 
ATOM   3275 C  CE1 . HIS   A 1 451 ? -5.606  -56.443 -26.287 1.00 28.51  ? 714  HIS   A CE1 1 
ATOM   3276 N  NE2 . HIS   A 1 451 ? -6.437  -55.567 -25.673 1.00 20.13  ? 714  HIS   A NE2 1 
ATOM   3277 N  N   . GLU   A 1 452 ? -7.590  -55.422 -32.325 1.00 33.36  ? 715  GLU   A N   1 
ATOM   3278 C  CA  . GLU   A 1 452 ? -8.133  -55.920 -33.606 1.00 33.90  ? 715  GLU   A CA  1 
ATOM   3279 C  C   . GLU   A 1 452 ? -8.437  -57.412 -33.432 1.00 34.81  ? 715  GLU   A C   1 
ATOM   3280 O  O   . GLU   A 1 452 ? -7.601  -58.145 -32.995 1.00 34.94  ? 715  GLU   A O   1 
ATOM   3281 C  CB  . GLU   A 1 452 ? -7.150  -55.682 -34.732 1.00 36.61  ? 715  GLU   A CB  1 
ATOM   3282 C  CG  . GLU   A 1 452 ? -7.868  -55.323 -36.010 1.00 44.26  ? 715  GLU   A CG  1 
ATOM   3283 C  CD  . GLU   A 1 452 ? -6.956  -55.000 -37.182 1.00 50.55  ? 715  GLU   A CD  1 
ATOM   3284 O  OE1 . GLU   A 1 452 ? -7.302  -54.054 -37.971 1.00 48.64  ? 715  GLU   A OE1 1 
ATOM   3285 O  OE2 . GLU   A 1 452 ? -5.916  -55.700 -37.306 1.00 56.48  ? 715  GLU   A OE2 1 
ATOM   3286 N  N   . LEU   A 1 453 ? -9.665  -57.820 -33.660 1.00 31.35  ? 716  LEU   A N   1 
ATOM   3287 C  CA  . LEU   A 1 453 ? -10.129 -59.171 -33.297 1.00 33.93  ? 716  LEU   A CA  1 
ATOM   3288 C  C   . LEU   A 1 453 ? -10.895 -59.719 -34.500 1.00 34.23  ? 716  LEU   A C   1 
ATOM   3289 O  O   . LEU   A 1 453 ? -11.830 -59.032 -35.012 1.00 36.87  ? 716  LEU   A O   1 
ATOM   3290 C  CB  . LEU   A 1 453 ? -10.956 -58.955 -32.037 1.00 38.26  ? 716  LEU   A CB  1 
ATOM   3291 C  CG  . LEU   A 1 453 ? -11.752 -60.131 -31.524 1.00 43.91  ? 716  LEU   A CG  1 
ATOM   3292 C  CD1 . LEU   A 1 453 ? -10.830 -61.283 -31.182 1.00 49.01  ? 716  LEU   A CD1 1 
ATOM   3293 C  CD2 . LEU   A 1 453 ? -12.558 -59.692 -30.308 1.00 47.49  ? 716  LEU   A CD2 1 
ATOM   3294 N  N   . ILE   A 1 454 ? -10.412 -60.830 -35.027 1.00 35.97  ? 717  ILE   A N   1 
ATOM   3295 C  CA  . ILE   A 1 454 ? -10.941 -61.441 -36.278 1.00 38.51  ? 717  ILE   A CA  1 
ATOM   3296 C  C   . ILE   A 1 454 ? -11.940 -62.535 -35.895 1.00 34.59  ? 717  ILE   A C   1 
ATOM   3297 O  O   . ILE   A 1 454 ? -11.640 -63.426 -35.061 1.00 33.51  ? 717  ILE   A O   1 
ATOM   3298 C  CB  . ILE   A 1 454 ? -9.780  -61.896 -37.191 1.00 44.36  ? 717  ILE   A CB  1 
ATOM   3299 C  CG1 . ILE   A 1 454 ? -8.932  -60.693 -37.625 1.00 46.21  ? 717  ILE   A CG1 1 
ATOM   3300 C  CG2 . ILE   A 1 454 ? -10.291 -62.642 -38.421 1.00 46.72  ? 717  ILE   A CG2 1 
ATOM   3301 C  CD1 . ILE   A 1 454 ? -7.570  -61.067 -38.122 1.00 48.43  ? 717  ILE   A CD1 1 
ATOM   3302 N  N   . MET   A 1 455 ? -13.147 -62.394 -36.397 1.00 36.39  ? 718  MET   A N   1 
ATOM   3303 C  CA  . MET   A 1 455 ? -14.226 -63.384 -36.154 1.00 40.55  ? 718  MET   A CA  1 
ATOM   3304 C  C   . MET   A 1 455 ? -13.958 -64.622 -37.001 1.00 40.12  ? 718  MET   A C   1 
ATOM   3305 O  O   . MET   A 1 455 ? -13.362 -64.516 -38.057 1.00 38.54  ? 718  MET   A O   1 
ATOM   3306 C  CB  . MET   A 1 455 ? -15.596 -62.829 -36.554 1.00 39.81  ? 718  MET   A CB  1 
ATOM   3307 C  CG  . MET   A 1 455 ? -16.010 -61.638 -35.746 1.00 43.14  ? 718  MET   A CG  1 
ATOM   3308 S  SD  . MET   A 1 455 ? -17.588 -60.928 -36.291 1.00 43.51  ? 718  MET   A SD  1 
ATOM   3309 C  CE  . MET   A 1 455 ? -18.716 -62.170 -35.672 1.00 43.75  ? 718  MET   A CE  1 
ATOM   3310 N  N   A LYS   A 1 456 ? -14.433 -65.776 -36.540 0.25 42.18  ? 719  LYS   A N   1 
ATOM   3311 N  N   B LYS   A 1 456 ? -14.426 -65.772 -36.516 0.25 42.65  ? 719  LYS   A N   1 
ATOM   3312 C  CA  A LYS   A 1 456 ? -14.284 -67.076 -37.243 0.25 44.71  ? 719  LYS   A CA  1 
ATOM   3313 C  CA  B LYS   A 1 456 ? -14.372 -67.087 -37.208 0.25 45.50  ? 719  LYS   A CA  1 
ATOM   3314 C  C   A LYS   A 1 456 ? -14.701 -66.919 -38.716 0.25 44.08  ? 719  LYS   A C   1 
ATOM   3315 C  C   B LYS   A 1 456 ? -14.686 -66.895 -38.700 0.25 44.39  ? 719  LYS   A C   1 
ATOM   3316 O  O   A LYS   A 1 456 ? -14.135 -67.640 -39.553 0.25 45.57  ? 719  LYS   A O   1 
ATOM   3317 O  O   B LYS   A 1 456 ? -14.037 -67.561 -39.524 0.25 45.30  ? 719  LYS   A O   1 
ATOM   3318 C  CB  A LYS   A 1 456 ? -15.065 -68.154 -36.486 0.25 46.80  ? 719  LYS   A CB  1 
ATOM   3319 C  CB  B LYS   A 1 456 ? -15.338 -68.057 -36.519 0.25 48.33  ? 719  LYS   A CB  1 
ATOM   3320 C  CG  A LYS   A 1 456 ? -14.312 -68.766 -35.313 0.25 48.73  ? 719  LYS   A CG  1 
ATOM   3321 C  CG  B LYS   A 1 456 ? -15.357 -69.471 -37.082 0.25 51.48  ? 719  LYS   A CG  1 
ATOM   3322 C  CD  A LYS   A 1 456 ? -15.162 -69.647 -34.424 0.25 50.55  ? 719  LYS   A CD  1 
ATOM   3323 C  CD  B LYS   A 1 456 ? -15.296 -70.546 -36.013 0.25 53.00  ? 719  LYS   A CD  1 
ATOM   3324 C  CE  A LYS   A 1 456 ? -15.900 -68.873 -33.351 0.25 51.16  ? 719  LYS   A CE  1 
ATOM   3325 C  CE  B LYS   A 1 456 ? -15.629 -71.929 -36.531 0.25 54.09  ? 719  LYS   A CE  1 
ATOM   3326 N  NZ  A LYS   A 1 456 ? -16.838 -69.745 -32.605 0.25 50.64  ? 719  LYS   A NZ  1 
ATOM   3327 N  NZ  B LYS   A 1 456 ? -15.136 -72.983 -35.612 0.25 55.05  ? 719  LYS   A NZ  1 
ATOM   3328 N  N   . ASP   A 1 457 ? -15.608 -65.987 -39.034 1.00 42.00  ? 720  ASP   A N   1 
ATOM   3329 C  CA  . ASP   A 1 457 ? -16.029 -65.732 -40.451 1.00 42.61  ? 720  ASP   A CA  1 
ATOM   3330 C  C   . ASP   A 1 457 ? -15.187 -64.667 -41.179 1.00 48.31  ? 720  ASP   A C   1 
ATOM   3331 O  O   . ASP   A 1 457 ? -15.628 -64.233 -42.250 1.00 43.84  ? 720  ASP   A O   1 
ATOM   3332 C  CB  . ASP   A 1 457 ? -17.505 -65.320 -40.516 1.00 49.83  ? 720  ASP   A CB  1 
ATOM   3333 C  CG  . ASP   A 1 457 ? -17.855 -64.054 -39.755 1.00 52.28  ? 720  ASP   A CG  1 
ATOM   3334 O  OD1 . ASP   A 1 457 ? -17.002 -63.129 -39.716 1.00 49.63  ? 720  ASP   A OD1 1 
ATOM   3335 O  OD2 . ASP   A 1 457 ? -18.995 -63.987 -39.247 1.00 55.60  ? 720  ASP   A OD2 1 
ATOM   3336 N  N   . GLY   A 1 458 ? -14.055 -64.217 -40.618 1.00 50.35  ? 721  GLY   A N   1 
ATOM   3337 C  CA  . GLY   A 1 458 ? -13.128 -63.276 -41.267 1.00 46.13  ? 721  GLY   A CA  1 
ATOM   3338 C  C   . GLY   A 1 458 ? -13.465 -61.813 -41.004 1.00 47.22  ? 721  GLY   A C   1 
ATOM   3339 O  O   . GLY   A 1 458 ? -12.586 -60.968 -41.249 1.00 48.22  ? 721  GLY   A O   1 
ATOM   3340 N  N   . ARG   A 1 459 ? -14.667 -61.470 -40.518 1.00 39.78  ? 722  ARG   A N   1 
ATOM   3341 C  CA  . ARG   A 1 459 ? -14.993 -60.032 -40.329 1.00 37.35  ? 722  ARG   A CA  1 
ATOM   3342 C  C   . ARG   A 1 459 ? -14.148 -59.459 -39.165 1.00 36.84  ? 722  ARG   A C   1 
ATOM   3343 O  O   . ARG   A 1 459 ? -13.734 -60.194 -38.233 1.00 34.41  ? 722  ARG   A O   1 
ATOM   3344 C  CB  . ARG   A 1 459 ? -16.502 -59.852 -40.166 1.00 39.58  ? 722  ARG   A CB  1 
ATOM   3345 C  CG  . ARG   A 1 459 ? -17.313 -60.303 -41.376 1.00 40.55  ? 722  ARG   A CG  1 
ATOM   3346 C  CD  . ARG   A 1 459 ? -18.802 -60.006 -41.241 1.00 38.19  ? 722  ARG   A CD  1 
ATOM   3347 N  NE  . ARG   A 1 459 ? -19.427 -60.871 -40.270 1.00 35.37  ? 722  ARG   A NE  1 
ATOM   3348 C  CZ  . ARG   A 1 459 ? -20.715 -60.858 -39.978 1.00 39.81  ? 722  ARG   A CZ  1 
ATOM   3349 N  NH1 . ARG   A 1 459 ? -21.524 -60.007 -40.583 1.00 40.97  ? 722  ARG   A NH1 1 
ATOM   3350 N  NH2 . ARG   A 1 459 ? -21.202 -61.714 -39.095 1.00 39.96  ? 722  ARG   A NH2 1 
ATOM   3351 N  N   . VAL   A 1 460 ? -13.944 -58.153 -39.162 1.00 34.92  ? 723  VAL   A N   1 
ATOM   3352 C  CA  . VAL   A 1 460 ? -12.990 -57.519 -38.217 1.00 32.93  ? 723  VAL   A CA  1 
ATOM   3353 C  C   . VAL   A 1 460 ? -13.725 -56.631 -37.217 1.00 30.92  ? 723  VAL   A C   1 
ATOM   3354 O  O   . VAL   A 1 460 ? -14.363 -55.649 -37.623 1.00 37.81  ? 723  VAL   A O   1 
ATOM   3355 C  CB  . VAL   A 1 460 ? -11.892 -56.766 -38.982 1.00 35.71  ? 723  VAL   A CB  1 
ATOM   3356 C  CG1 . VAL   A 1 460 ? -10.866 -56.172 -38.024 1.00 42.81  ? 723  VAL   A CG1 1 
ATOM   3357 C  CG2 . VAL   A 1 460 ? -11.190 -57.700 -39.949 1.00 38.96  ? 723  VAL   A CG2 1 
ATOM   3358 N  N   . LEU   A 1 461 ? -13.577 -56.957 -35.933 1.00 29.51  ? 724  LEU   A N   1 
ATOM   3359 C  CA  . LEU   A 1 461 ? -13.997 -56.121 -34.792 1.00 28.20  ? 724  LEU   A CA  1 
ATOM   3360 C  C   . LEU   A 1 461 ? -12.783 -55.352 -34.261 1.00 31.26  ? 724  LEU   A C   1 
ATOM   3361 O  O   . LEU   A 1 461 ? -11.714 -55.970 -34.022 1.00 34.10  ? 724  LEU   A O   1 
ATOM   3362 C  CB  . LEU   A 1 461 ? -14.559 -57.063 -33.737 1.00 30.69  ? 724  LEU   A CB  1 
ATOM   3363 C  CG  . LEU   A 1 461 ? -15.718 -57.915 -34.232 1.00 28.91  ? 724  LEU   A CG  1 
ATOM   3364 C  CD1 . LEU   A 1 461 ? -16.088 -58.907 -33.170 1.00 33.08  ? 724  LEU   A CD1 1 
ATOM   3365 C  CD2 . LEU   A 1 461 ? -16.896 -57.053 -34.608 1.00 29.05  ? 724  LEU   A CD2 1 
ATOM   3366 N  N   . VAL   A 1 462 ? -12.932 -54.046 -34.082 1.00 29.53  ? 725  VAL   A N   1 
ATOM   3367 C  CA  . VAL   A 1 462 ? -12.004 -53.226 -33.269 1.00 26.80  ? 725  VAL   A CA  1 
ATOM   3368 C  C   . VAL   A 1 462 ? -12.722 -52.909 -31.969 1.00 27.18  ? 725  VAL   A C   1 
ATOM   3369 O  O   . VAL   A 1 462 ? -13.742 -52.205 -32.038 1.00 26.49  ? 725  VAL   A O   1 
ATOM   3370 C  CB  . VAL   A 1 462 ? -11.581 -51.946 -33.994 1.00 27.46  ? 725  VAL   A CB  1 
ATOM   3371 C  CG1 . VAL   A 1 462 ? -10.688 -51.118 -33.063 1.00 28.57  ? 725  VAL   A CG1 1 
ATOM   3372 C  CG2 . VAL   A 1 462 ? -10.886 -52.277 -35.296 1.00 28.31  ? 725  VAL   A CG2 1 
ATOM   3373 N  N   . VAL   A 1 463 ? -12.194 -53.429 -30.860 1.00 26.69  ? 726  VAL   A N   1 
ATOM   3374 C  CA  . VAL   A 1 463 ? -12.912 -53.562 -29.559 1.00 23.20  ? 726  VAL   A CA  1 
ATOM   3375 C  C   . VAL   A 1 463 ? -12.181 -52.748 -28.509 1.00 22.78  ? 726  VAL   A C   1 
ATOM   3376 O  O   . VAL   A 1 463 ? -10.953 -52.690 -28.501 1.00 27.86  ? 726  VAL   A O   1 
ATOM   3377 C  CB  . VAL   A 1 463 ? -13.033 -55.036 -29.135 1.00 24.96  ? 726  VAL   A CB  1 
ATOM   3378 C  CG1 . VAL   A 1 463 ? -13.941 -55.799 -30.096 1.00 25.98  ? 726  VAL   A CG1 1 
ATOM   3379 C  CG2 . VAL   A 1 463 ? -11.670 -55.724 -28.994 1.00 23.96  ? 726  VAL   A CG2 1 
ATOM   3380 N  N   . PRO   A 1 464 ? -12.908 -52.087 -27.599 1.00 23.16  ? 727  PRO   A N   1 
ATOM   3381 C  CA  . PRO   A 1 464 ? -12.261 -51.333 -26.529 1.00 22.71  ? 727  PRO   A CA  1 
ATOM   3382 C  C   . PRO   A 1 464 ? -11.868 -52.270 -25.408 1.00 24.50  ? 727  PRO   A C   1 
ATOM   3383 O  O   . PRO   A 1 464 ? -12.524 -53.277 -25.263 1.00 20.62  ? 727  PRO   A O   1 
ATOM   3384 C  CB  . PRO   A 1 464 ? -13.394 -50.453 -26.020 1.00 23.67  ? 727  PRO   A CB  1 
ATOM   3385 C  CG  . PRO   A 1 464 ? -14.637 -51.355 -26.207 1.00 23.49  ? 727  PRO   A CG  1 
ATOM   3386 C  CD  . PRO   A 1 464 ? -14.379 -52.015 -27.551 1.00 22.54  ? 727  PRO   A CD  1 
ATOM   3387 N  N   . CYS   A 1 465 ? -10.853 -51.877 -24.632 1.00 24.07  ? 728  CYS   A N   1 
ATOM   3388 C  CA  . CYS   A 1 465 ? -10.245 -52.729 -23.583 1.00 24.29  ? 728  CYS   A CA  1 
ATOM   3389 C  C   . CYS   A 1 465 ? -9.581  -51.843 -22.534 1.00 26.94  ? 728  CYS   A C   1 
ATOM   3390 O  O   . CYS   A 1 465 ? -9.168  -50.739 -22.893 1.00 23.61  ? 728  CYS   A O   1 
ATOM   3391 C  CB  . CYS   A 1 465 ? -9.221  -53.697 -24.185 1.00 23.49  ? 728  CYS   A CB  1 
ATOM   3392 S  SG  . CYS   A 1 465 ? -8.756  -55.022 -23.031 1.00 24.21  ? 728  CYS   A SG  1 
ATOM   3393 N  N   . ARG   A 1 466 ? -9.549  -52.285 -21.282 1.00 26.69  ? 729  ARG   A N   1 
ATOM   3394 C  CA  . ARG   A 1 466 ? -8.630  -51.749 -20.272 1.00 26.96  ? 729  ARG   A CA  1 
ATOM   3395 C  C   . ARG   A 1 466 ? -8.386  -52.816 -19.222 1.00 25.74  ? 729  ARG   A C   1 
ATOM   3396 O  O   . ARG   A 1 466 ? -9.038  -53.887 -19.265 1.00 24.84  ? 729  ARG   A O   1 
ATOM   3397 C  CB  . ARG   A 1 466 ? -9.168  -50.474 -19.645 1.00 32.59  ? 729  ARG   A CB  1 
ATOM   3398 C  CG  . ARG   A 1 466 ? -10.502 -50.641 -18.948 1.00 35.92  ? 729  ARG   A CG  1 
ATOM   3399 C  CD  . ARG   A 1 466 ? -11.215 -49.312 -18.708 1.00 33.91  ? 729  ARG   A CD  1 
ATOM   3400 N  NE  . ARG   A 1 466 ? -10.693 -48.548 -17.595 1.00 31.80  ? 729  ARG   A NE  1 
ATOM   3401 C  CZ  . ARG   A 1 466 ? -11.244 -47.426 -17.131 1.00 34.66  ? 729  ARG   A CZ  1 
ATOM   3402 N  NH1 . ARG   A 1 466 ? -12.365 -46.923 -17.631 1.00 35.86  ? 729  ARG   A NH1 1 
ATOM   3403 N  NH2 . ARG   A 1 466 ? -10.663 -46.802 -16.146 1.00 35.56  ? 729  ARG   A NH2 1 
ATOM   3404 N  N   . ASN   A 1 467 ? -7.454  -52.538 -18.318 1.00 26.54  ? 730  ASN   A N   1 
ATOM   3405 C  CA  . ASN   A 1 467 ? -7.068  -53.496 -17.267 1.00 27.95  ? 730  ASN   A CA  1 
ATOM   3406 C  C   . ASN   A 1 467 ? -8.367  -53.946 -16.573 1.00 26.32  ? 730  ASN   A C   1 
ATOM   3407 O  O   . ASN   A 1 467 ? -9.075  -53.101 -16.093 1.00 26.35  ? 730  ASN   A O   1 
ATOM   3408 C  CB  . ASN   A 1 467 ? -6.035  -52.939 -16.284 1.00 29.31  ? 730  ASN   A CB  1 
ATOM   3409 C  CG  . ASN   A 1 467 ? -5.763  -53.979 -15.223 1.00 31.78  ? 730  ASN   A CG  1 
ATOM   3410 O  OD1 . ASN   A 1 467 ? -6.512  -54.086 -14.269 1.00 27.04  ? 730  ASN   A OD1 1 
ATOM   3411 N  ND2 . ASN   A 1 467 ? -4.780  -54.839 -15.456 1.00 36.23  ? 730  ASN   A ND2 1 
ATOM   3412 N  N   . GLN   A 1 468 ? -8.559  -55.252 -16.432 1.00 23.46  ? 731  GLN   A N   1 
ATOM   3413 C  CA  . GLN   A 1 468 ? -9.839  -55.849 -16.016 1.00 25.16  ? 731  GLN   A CA  1 
ATOM   3414 C  C   . GLN   A 1 468 ? -10.085 -55.533 -14.550 1.00 24.91  ? 731  GLN   A C   1 
ATOM   3415 O  O   . GLN   A 1 468 ? -11.275 -55.434 -14.150 1.00 21.87  ? 731  GLN   A O   1 
ATOM   3416 C  CB  . GLN   A 1 468 ? -9.861  -57.351 -16.309 1.00 26.24  ? 731  GLN   A CB  1 
ATOM   3417 C  CG  . GLN   A 1 468 ? -11.252 -57.962 -16.222 1.00 24.63  ? 731  GLN   A CG  1 
ATOM   3418 C  CD  . GLN   A 1 468 ? -11.168 -59.461 -16.411 1.00 24.40  ? 731  GLN   A CD  1 
ATOM   3419 O  OE1 . GLN   A 1 468 ? -11.406 -59.965 -17.493 1.00 23.04  ? 731  GLN   A OE1 1 
ATOM   3420 N  NE2 . GLN   A 1 468 ? -10.840 -60.197 -15.360 1.00 24.59  ? 731  GLN   A NE2 1 
ATOM   3421 N  N   . ASP   A 1 469 ? -9.031  -55.355 -13.778 1.00 25.98  ? 732  ASP   A N   1 
ATOM   3422 C  CA  . ASP   A 1 469 ? -9.173  -54.921 -12.361 1.00 28.29  ? 732  ASP   A CA  1 
ATOM   3423 C  C   . ASP   A 1 469 ? -9.942  -53.598 -12.291 1.00 27.66  ? 732  ASP   A C   1 
ATOM   3424 O  O   . ASP   A 1 469 ? -10.711 -53.407 -11.322 1.00 29.42  ? 732  ASP   A O   1 
ATOM   3425 C  CB  . ASP   A 1 469 ? -7.829  -54.804 -11.644 1.00 29.64  ? 732  ASP   A CB  1 
ATOM   3426 C  CG  . ASP   A 1 469 ? -7.131  -56.137 -11.425 1.00 33.59  ? 732  ASP   A CG  1 
ATOM   3427 O  OD1 . ASP   A 1 469 ? -7.797  -57.195 -11.553 1.00 33.38  ? 732  ASP   A OD1 1 
ATOM   3428 O  OD2 . ASP   A 1 469 ? -5.917  -56.107 -11.162 1.00 36.26  ? 732  ASP   A OD2 1 
ATOM   3429 N  N   . GLU   A 1 470 ? -9.659  -52.676 -13.198 1.00 25.64  ? 733  GLU   A N   1 
ATOM   3430 C  CA  . GLU   A 1 470 ? -10.323 -51.362 -13.232 1.00 27.00  ? 733  GLU   A CA  1 
ATOM   3431 C  C   . GLU   A 1 470 ? -11.816 -51.613 -13.526 1.00 26.89  ? 733  GLU   A C   1 
ATOM   3432 O  O   . GLU   A 1 470 ? -12.649 -51.003 -12.861 1.00 28.44  ? 733  GLU   A O   1 
ATOM   3433 C  CB  . GLU   A 1 470 ? -9.733  -50.465 -14.312 1.00 27.32  ? 733  GLU   A CB  1 
ATOM   3434 C  CG  . GLU   A 1 470 ? -8.288  -50.033 -14.070 1.00 33.59  ? 733  GLU   A CG  1 
ATOM   3435 C  CD  . GLU   A 1 470 ? -7.613  -49.329 -15.248 1.00 35.94  ? 733  GLU   A CD  1 
ATOM   3436 O  OE1 . GLU   A 1 470 ? -6.380  -49.287 -15.255 1.00 43.95  ? 733  GLU   A OE1 1 
ATOM   3437 O  OE2 . GLU   A 1 470 ? -8.320  -48.833 -16.170 1.00 36.40  ? 733  GLU   A OE2 1 
ATOM   3438 N  N   . LEU   A 1 471 ? -12.134 -52.470 -14.493 1.00 24.45  ? 734  LEU   A N   1 
ATOM   3439 C  CA  . LEU   A 1 471 ? -13.534 -52.733 -14.877 1.00 24.33  ? 734  LEU   A CA  1 
ATOM   3440 C  C   . LEU   A 1 471 ? -14.303 -53.358 -13.710 1.00 26.35  ? 734  LEU   A C   1 
ATOM   3441 O  O   . LEU   A 1 471 ? -15.448 -52.881 -13.367 1.00 26.11  ? 734  LEU   A O   1 
ATOM   3442 C  CB  . LEU   A 1 471 ? -13.561 -53.588 -16.132 1.00 22.86  ? 734  LEU   A CB  1 
ATOM   3443 C  CG  . LEU   A 1 471 ? -13.051 -52.856 -17.373 1.00 25.92  ? 734  LEU   A CG  1 
ATOM   3444 C  CD1 . LEU   A 1 471 ? -13.054 -53.748 -18.592 1.00 24.76  ? 734  LEU   A CD1 1 
ATOM   3445 C  CD2 . LEU   A 1 471 ? -13.862 -51.619 -17.650 1.00 28.48  ? 734  LEU   A CD2 1 
ATOM   3446 N  N   . ILE   A 1 472 ? -13.717 -54.342 -13.062 1.00 26.12  ? 735  ILE   A N   1 
ATOM   3447 C  CA  . ILE   A 1 472 ? -14.427 -55.059 -11.981 1.00 26.14  ? 735  ILE   A CA  1 
ATOM   3448 C  C   . ILE   A 1 472 ? -14.552 -54.152 -10.756 1.00 26.24  ? 735  ILE   A C   1 
ATOM   3449 O  O   . ILE   A 1 472 ? -15.639 -54.156 -10.117 1.00 23.39  ? 735  ILE   A O   1 
ATOM   3450 C  CB  . ILE   A 1 472 ? -13.751 -56.400 -11.705 1.00 25.74  ? 735  ILE   A CB  1 
ATOM   3451 C  CG1 . ILE   A 1 472 ? -13.989 -57.296 -12.911 1.00 27.59  ? 735  ILE   A CG1 1 
ATOM   3452 C  CG2 . ILE   A 1 472 ? -14.256 -57.005 -10.399 1.00 26.73  ? 735  ILE   A CG2 1 
ATOM   3453 C  CD1 . ILE   A 1 472 ? -13.302 -58.617 -12.823 1.00 31.28  ? 735  ILE   A CD1 1 
ATOM   3454 N  N   . GLY   A 1 473 ? -13.508 -53.403 -10.446 1.00 25.24  ? 736  GLY   A N   1 
ATOM   3455 C  CA  . GLY   A 1 473 ? -13.496 -52.483 -9.287  1.00 28.75  ? 736  GLY   A CA  1 
ATOM   3456 C  C   . GLY   A 1 473 ? -14.580 -51.401 -9.387  1.00 31.62  ? 736  GLY   A C   1 
ATOM   3457 O  O   . GLY   A 1 473 ? -15.220 -51.088 -8.340  1.00 33.02  ? 736  GLY   A O   1 
ATOM   3458 N  N   . ARG   A 1 474 ? -14.805 -50.867 -10.591 1.00 27.78  ? 737  ARG   A N   1 
ATOM   3459 C  CA  . ARG   A 1 474 ? -15.796 -49.787 -10.861 1.00 28.57  ? 737  ARG   A CA  1 
ATOM   3460 C  C   . ARG   A 1 474 ? -17.211 -50.374 -10.743 1.00 27.60  ? 737  ARG   A C   1 
ATOM   3461 O  O   . ARG   A 1 474 ? -18.059 -49.686 -10.206 1.00 28.59  ? 737  ARG   A O   1 
ATOM   3462 C  CB  . ARG   A 1 474 ? -15.621 -49.154 -12.261 1.00 32.00  ? 737  ARG   A CB  1 
ATOM   3463 C  CG  . ARG   A 1 474 ? -14.207 -48.644 -12.571 1.00 45.52  ? 737  ARG   A CG  1 
ATOM   3464 C  CD  . ARG   A 1 474 ? -13.838 -48.377 -14.049 1.00 44.50  ? 737  ARG   A CD  1 
ATOM   3465 N  NE  . ARG   A 1 474 ? -14.417 -47.067 -14.271 1.00 60.10  ? 737  ARG   A NE  1 
ATOM   3466 C  CZ  . ARG   A 1 474 ? -13.916 -45.926 -13.791 1.00 58.05  ? 737  ARG   A CZ  1 
ATOM   3467 N  NH1 . ARG   A 1 474 ? -14.569 -44.791 -13.995 1.00 54.65  ? 737  ARG   A NH1 1 
ATOM   3468 N  NH2 . ARG   A 1 474 ? -12.754 -45.924 -13.151 1.00 55.79  ? 737  ARG   A NH2 1 
ATOM   3469 N  N   . ALA   A 1 475 ? -17.465 -51.590 -11.244 1.00 24.91  ? 738  ALA   A N   1 
ATOM   3470 C  CA  . ALA   A 1 475 ? -18.823 -52.195 -11.230 1.00 24.92  ? 738  ALA   A CA  1 
ATOM   3471 C  C   . ALA   A 1 475 ? -19.195 -52.516 -9.780  1.00 25.86  ? 738  ALA   A C   1 
ATOM   3472 O  O   . ALA   A 1 475 ? -20.382 -52.671 -9.481  1.00 29.06  ? 738  ALA   A O   1 
ATOM   3473 C  CB  . ALA   A 1 475 ? -18.895 -53.429 -12.101 1.00 22.62  ? 738  ALA   A CB  1 
ATOM   3474 N  N   . ARG   A 1 476 ? -18.207 -52.642 -8.892  1.00 27.73  ? 739  ARG   A N   1 
ATOM   3475 C  CA  . ARG   A 1 476 ? -18.462 -53.014 -7.476  1.00 28.32  ? 739  ARG   A CA  1 
ATOM   3476 C  C   . ARG   A 1 476 ? -18.816 -51.777 -6.649  1.00 30.36  ? 739  ARG   A C   1 
ATOM   3477 O  O   . ARG   A 1 476 ? -19.085 -51.913 -5.437  1.00 27.57  ? 739  ARG   A O   1 
ATOM   3478 C  CB  . ARG   A 1 476 ? -17.289 -53.811 -6.901  1.00 26.14  ? 739  ARG   A CB  1 
ATOM   3479 C  CG  . ARG   A 1 476 ? -17.333 -55.268 -7.353  1.00 28.62  ? 739  ARG   A CG  1 
ATOM   3480 C  CD  . ARG   A 1 476 ? -15.969 -55.966 -7.240  1.00 29.30  ? 739  ARG   A CD  1 
ATOM   3481 N  NE  . ARG   A 1 476 ? -15.513 -56.238 -5.881  1.00 26.35  ? 739  ARG   A NE  1 
ATOM   3482 C  CZ  . ARG   A 1 476 ? -15.219 -57.434 -5.367  1.00 25.81  ? 739  ARG   A CZ  1 
ATOM   3483 N  NH1 . ARG   A 1 476 ? -15.356 -58.560 -6.037  1.00 28.11  ? 739  ARG   A NH1 1 
ATOM   3484 N  NH2 . ARG   A 1 476 ? -14.787 -57.509 -4.134  1.00 27.14  ? 739  ARG   A NH2 1 
ATOM   3485 N  N   . ILE   A 1 477 ? -18.825 -50.608 -7.257  1.00 33.06  ? 740  ILE   A N   1 
ATOM   3486 C  CA  . ILE   A 1 477 ? -19.095 -49.364 -6.498  1.00 40.99  ? 740  ILE   A CA  1 
ATOM   3487 C  C   . ILE   A 1 477 ? -20.414 -48.764 -6.968  1.00 45.25  ? 740  ILE   A C   1 
ATOM   3488 O  O   . ILE   A 1 477 ? -20.647 -48.674 -8.192  1.00 39.59  ? 740  ILE   A O   1 
ATOM   3489 C  CB  . ILE   A 1 477 ? -17.936 -48.374 -6.672  1.00 40.43  ? 740  ILE   A CB  1 
ATOM   3490 C  CG1 . ILE   A 1 477 ? -16.655 -48.871 -6.000  1.00 38.10  ? 740  ILE   A CG1 1 
ATOM   3491 C  CG2 . ILE   A 1 477 ? -18.339 -47.011 -6.165  1.00 44.94  ? 740  ILE   A CG2 1 
ATOM   3492 C  CD1 . ILE   A 1 477 ? -15.453 -48.002 -6.294  1.00 40.92  ? 740  ILE   A CD1 1 
ATOM   3493 N  N   A SER   A 1 478 ? -21.259 -48.391 -6.004  0.22 48.46  ? 741  SER   A N   1 
ATOM   3494 N  N   B SER   A 1 478 ? -21.272 -48.382 -6.016  0.22 47.71  ? 741  SER   A N   1 
ATOM   3495 C  CA  A SER   A 1 478 ? -22.436 -47.503 -6.187  0.22 54.59  ? 741  SER   A CA  1 
ATOM   3496 C  CA  B SER   A 1 478 ? -22.452 -47.503 -6.240  0.22 53.13  ? 741  SER   A CA  1 
ATOM   3497 C  C   A SER   A 1 478 ? -22.055 -46.092 -5.727  0.22 59.92  ? 741  SER   A C   1 
ATOM   3498 C  C   B SER   A 1 478 ? -22.161 -46.117 -5.650  0.22 59.26  ? 741  SER   A C   1 
ATOM   3499 O  O   A SER   A 1 478 ? -21.099 -45.974 -4.929  0.22 61.62  ? 741  SER   A O   1 
ATOM   3500 O  O   B SER   A 1 478 ? -21.395 -46.044 -4.664  0.22 62.20  ? 741  SER   A O   1 
ATOM   3501 C  CB  A SER   A 1 478 ? -23.632 -48.026 -5.437  0.22 53.86  ? 741  SER   A CB  1 
ATOM   3502 C  CB  B SER   A 1 478 ? -23.724 -48.097 -5.678  0.22 51.29  ? 741  SER   A CB  1 
ATOM   3503 O  OG  A SER   A 1 478 ? -24.693 -47.084 -5.464  0.22 55.18  ? 741  SER   A OG  1 
ATOM   3504 O  OG  B SER   A 1 478 ? -23.467 -49.262 -4.907  0.22 50.13  ? 741  SER   A OG  1 
ATOM   3505 N  N   . GLN   A 1 479 ? -22.743 -45.067 -6.243  1.00 67.08  ? 742  GLN   A N   1 
ATOM   3506 C  CA  . GLN   A 1 479 ? -22.574 -43.653 -5.781  1.00 75.07  ? 742  GLN   A CA  1 
ATOM   3507 C  C   . GLN   A 1 479 ? -23.864 -43.249 -5.062  1.00 78.42  ? 742  GLN   A C   1 
ATOM   3508 O  O   . GLN   A 1 479 ? -24.953 -43.564 -5.585  1.00 66.99  ? 742  GLN   A O   1 
ATOM   3509 C  CB  . GLN   A 1 479 ? -22.236 -42.672 -6.915  1.00 84.76  ? 742  GLN   A CB  1 
ATOM   3510 C  CG  . GLN   A 1 479 ? -20.860 -42.861 -7.573  1.00 101.98 ? 742  GLN   A CG  1 
ATOM   3511 C  CD  . GLN   A 1 479 ? -19.655 -43.090 -6.675  1.00 110.42 ? 742  GLN   A CD  1 
ATOM   3512 O  OE1 . GLN   A 1 479 ? -19.708 -42.975 -5.449  1.00 112.79 ? 742  GLN   A OE1 1 
ATOM   3513 N  NE2 . GLN   A 1 479 ? -18.524 -43.413 -7.291  1.00 99.38  ? 742  GLN   A NE2 1 
ATOM   3514 N  N   . GLY   A 1 480 ? -23.723 -42.614 -3.892  1.00 80.78  ? 743  GLY   A N   1 
ATOM   3515 C  CA  . GLY   A 1 480 ? -24.839 -42.260 -2.997  1.00 81.03  ? 743  GLY   A CA  1 
ATOM   3516 C  C   . GLY   A 1 480 ? -25.442 -43.495 -2.346  1.00 80.20  ? 743  GLY   A C   1 
ATOM   3517 O  O   . GLY   A 1 480 ? -25.024 -44.631 -2.680  1.00 80.72  ? 743  GLY   A O   1 
ATOM   3518 N  N   . ALA   A 1 481 ? -26.400 -43.275 -1.445  1.00 78.88  ? 744  ALA   A N   1 
ATOM   3519 C  CA  . ALA   A 1 481 ? -27.081 -44.330 -0.667  1.00 76.46  ? 744  ALA   A CA  1 
ATOM   3520 C  C   . ALA   A 1 481 ? -28.605 -44.072 -0.633  1.00 67.64  ? 744  ALA   A C   1 
ATOM   3521 O  O   . ALA   A 1 481 ? -29.112 -43.208 -1.379  1.00 51.76  ? 744  ALA   A O   1 
ATOM   3522 C  CB  . ALA   A 1 481 ? -26.439 -44.425 0.702   1.00 79.54  ? 744  ALA   A CB  1 
ATOM   3523 N  N   . GLY   A 1 482 ? -29.328 -44.866 0.159   1.00 59.94  ? 745  GLY   A N   1 
ATOM   3524 C  CA  . GLY   A 1 482 ? -30.798 -44.979 0.121   1.00 50.95  ? 745  GLY   A CA  1 
ATOM   3525 C  C   . GLY   A 1 482 ? -31.225 -46.021 -0.888  1.00 47.78  ? 745  GLY   A C   1 
ATOM   3526 O  O   . GLY   A 1 482 ? -32.400 -46.001 -1.253  1.00 52.16  ? 745  GLY   A O   1 
ATOM   3527 N  N   . TRP   A 1 483 ? -30.297 -46.870 -1.368  1.00 41.68  ? 746  TRP   A N   1 
ATOM   3528 C  CA  . TRP   A 1 483 ? -30.543 -47.812 -2.494  1.00 40.13  ? 746  TRP   A CA  1 
ATOM   3529 C  C   . TRP   A 1 483 ? -31.247 -49.071 -1.972  1.00 35.52  ? 746  TRP   A C   1 
ATOM   3530 O  O   . TRP   A 1 483 ? -30.747 -49.763 -1.087  1.00 35.91  ? 746  TRP   A O   1 
ATOM   3531 C  CB  . TRP   A 1 483 ? -29.269 -48.194 -3.250  1.00 49.27  ? 746  TRP   A CB  1 
ATOM   3532 C  CG  . TRP   A 1 483 ? -28.594 -47.116 -4.036  1.00 59.68  ? 746  TRP   A CG  1 
ATOM   3533 C  CD1 . TRP   A 1 483 ? -27.990 -45.997 -3.540  1.00 80.13  ? 746  TRP   A CD1 1 
ATOM   3534 C  CD2 . TRP   A 1 483 ? -28.336 -47.104 -5.446  1.00 61.72  ? 746  TRP   A CD2 1 
ATOM   3535 N  NE1 . TRP   A 1 483 ? -27.408 -45.270 -4.545  1.00 80.66  ? 746  TRP   A NE1 1 
ATOM   3536 C  CE2 . TRP   A 1 483 ? -27.611 -45.925 -5.728  1.00 76.42  ? 746  TRP   A CE2 1 
ATOM   3537 C  CE3 . TRP   A 1 483 ? -28.652 -47.963 -6.497  1.00 58.04  ? 746  TRP   A CE3 1 
ATOM   3538 C  CZ2 . TRP   A 1 483 ? -27.212 -45.583 -7.018  1.00 70.07  ? 746  TRP   A CZ2 1 
ATOM   3539 C  CZ3 . TRP   A 1 483 ? -28.261 -47.623 -7.771  1.00 58.20  ? 746  TRP   A CZ3 1 
ATOM   3540 C  CH2 . TRP   A 1 483 ? -27.566 -46.444 -8.026  1.00 63.49  ? 746  TRP   A CH2 1 
ATOM   3541 N  N   . SER   A 1 484 ? -32.374 -49.386 -2.553  1.00 29.61  ? 747  SER   A N   1 
ATOM   3542 C  CA  . SER   A 1 484 ? -33.079 -50.659 -2.308  1.00 31.29  ? 747  SER   A CA  1 
ATOM   3543 C  C   . SER   A 1 484 ? -32.272 -51.822 -2.907  1.00 27.72  ? 747  SER   A C   1 
ATOM   3544 O  O   . SER   A 1 484 ? -31.391 -51.587 -3.755  1.00 26.29  ? 747  SER   A O   1 
ATOM   3545 C  CB  . SER   A 1 484 ? -34.485 -50.568 -2.879  1.00 30.34  ? 747  SER   A CB  1 
ATOM   3546 O  OG  . SER   A 1 484 ? -34.414 -50.558 -4.289  1.00 30.14  ? 747  SER   A OG  1 
ATOM   3547 N  N   . LEU   A 1 485 ? -32.591 -53.061 -2.526  1.00 29.10  ? 748  LEU   A N   1 
ATOM   3548 C  CA  . LEU   A 1 485 ? -31.959 -54.250 -3.150  1.00 29.90  ? 748  LEU   A CA  1 
ATOM   3549 C  C   . LEU   A 1 485 ? -32.221 -54.248 -4.663  1.00 31.54  ? 748  LEU   A C   1 
ATOM   3550 O  O   . LEU   A 1 485 ? -31.287 -54.569 -5.459  1.00 30.88  ? 748  LEU   A O   1 
ATOM   3551 C  CB  . LEU   A 1 485 ? -32.496 -55.510 -2.488  1.00 29.66  ? 748  LEU   A CB  1 
ATOM   3552 C  CG  . LEU   A 1 485 ? -31.922 -56.797 -3.054  1.00 33.22  ? 748  LEU   A CG  1 
ATOM   3553 C  CD1 . LEU   A 1 485 ? -30.407 -56.675 -3.144  1.00 35.43  ? 748  LEU   A CD1 1 
ATOM   3554 C  CD2 . LEU   A 1 485 ? -32.338 -57.975 -2.199  1.00 33.55  ? 748  LEU   A CD2 1 
ATOM   3555 N  N   . ARG   A 1 486 ? -33.444 -53.886 -5.050  1.00 29.48  ? 749  ARG   A N   1 
ATOM   3556 C  CA  . ARG   A 1 486 ? -33.894 -53.857 -6.458  1.00 30.44  ? 749  ARG   A CA  1 
ATOM   3557 C  C   . ARG   A 1 486 ? -33.056 -52.863 -7.285  1.00 29.41  ? 749  ARG   A C   1 
ATOM   3558 O  O   . ARG   A 1 486 ? -32.612 -53.216 -8.370  1.00 30.23  ? 749  ARG   A O   1 
ATOM   3559 C  CB  . ARG   A 1 486 ? -35.392 -53.541 -6.546  1.00 30.01  ? 749  ARG   A CB  1 
ATOM   3560 C  CG  . ARG   A 1 486 ? -35.856 -53.418 -7.990  1.00 31.91  ? 749  ARG   A CG  1 
ATOM   3561 C  CD  . ARG   A 1 486 ? -37.376 -53.405 -8.036  1.00 33.25  ? 749  ARG   A CD  1 
ATOM   3562 N  NE  . ARG   A 1 486 ? -37.881 -53.326 -9.401  1.00 31.28  ? 749  ARG   A NE  1 
ATOM   3563 C  CZ  . ARG   A 1 486 ? -39.004 -53.896 -9.816  1.00 32.10  ? 749  ARG   A CZ  1 
ATOM   3564 N  NH1 . ARG   A 1 486 ? -39.739 -54.595 -8.976  1.00 31.59  ? 749  ARG   A NH1 1 
ATOM   3565 N  NH2 . ARG   A 1 486 ? -39.395 -53.773 -11.069 1.00 31.80  ? 749  ARG   A NH2 1 
ATOM   3566 N  N   A GLU   A 1 487 ? -32.898 -51.644 -6.771  0.24 27.30  ? 750  GLU   A N   1 
ATOM   3567 N  N   B GLU   A 1 487 ? -32.855 -51.653 -6.765  0.25 27.06  ? 750  GLU   A N   1 
ATOM   3568 C  CA  A GLU   A 1 487 ? -32.092 -50.561 -7.390  0.24 27.03  ? 750  GLU   A CA  1 
ATOM   3569 C  CA  B GLU   A 1 487 ? -32.112 -50.572 -7.461  0.25 26.71  ? 750  GLU   A CA  1 
ATOM   3570 C  C   A GLU   A 1 487 ? -30.654 -51.057 -7.590  0.24 28.19  ? 750  GLU   A C   1 
ATOM   3571 C  C   B GLU   A 1 487 ? -30.621 -50.957 -7.559  0.25 27.97  ? 750  GLU   A C   1 
ATOM   3572 O  O   A GLU   A 1 487 ? -30.119 -50.973 -8.732  0.24 26.34  ? 750  GLU   A O   1 
ATOM   3573 O  O   B GLU   A 1 487 ? -30.004 -50.685 -8.620  0.25 26.36  ? 750  GLU   A O   1 
ATOM   3574 C  CB  A GLU   A 1 487 ? -32.111 -49.339 -6.473  0.24 27.27  ? 750  GLU   A CB  1 
ATOM   3575 C  CB  B GLU   A 1 487 ? -32.359 -49.245 -6.740  0.25 26.96  ? 750  GLU   A CB  1 
ATOM   3576 C  CG  A GLU   A 1 487 ? -31.783 -48.042 -7.177  0.24 26.45  ? 750  GLU   A CG  1 
ATOM   3577 C  CG  B GLU   A 1 487 ? -33.818 -48.800 -6.763  0.25 25.31  ? 750  GLU   A CG  1 
ATOM   3578 C  CD  A GLU   A 1 487 ? -31.805 -46.838 -6.256  0.24 24.82  ? 750  GLU   A CD  1 
ATOM   3579 C  CD  B GLU   A 1 487 ? -34.170 -47.764 -5.713  0.25 25.73  ? 750  GLU   A CD  1 
ATOM   3580 O  OE1 A GLU   A 1 487 ? -32.516 -46.906 -5.238  0.24 24.12  ? 750  GLU   A OE1 1 
ATOM   3581 O  OE1 B GLU   A 1 487 ? -33.311 -47.479 -4.870  0.25 25.70  ? 750  GLU   A OE1 1 
ATOM   3582 O  OE2 A GLU   A 1 487 ? -31.133 -45.837 -6.573  0.24 24.16  ? 750  GLU   A OE2 1 
ATOM   3583 O  OE2 B GLU   A 1 487 ? -35.305 -47.235 -5.743  0.25 28.87  ? 750  GLU   A OE2 1 
ATOM   3584 N  N   . THR   A 1 488 ? -30.076 -51.600 -6.518  1.00 30.16  ? 751  THR   A N   1 
ATOM   3585 C  CA  . THR   A 1 488 ? -28.686 -52.139 -6.508  1.00 26.66  ? 751  THR   A CA  1 
ATOM   3586 C  C   . THR   A 1 488 ? -28.570 -53.229 -7.590  1.00 28.76  ? 751  THR   A C   1 
ATOM   3587 O  O   . THR   A 1 488 ? -27.558 -53.206 -8.334  1.00 29.65  ? 751  THR   A O   1 
ATOM   3588 C  CB  . THR   A 1 488 ? -28.316 -52.760 -5.166  1.00 26.14  ? 751  THR   A CB  1 
ATOM   3589 O  OG1 . THR   A 1 488 ? -28.511 -51.712 -4.217  1.00 30.66  ? 751  THR   A OG1 1 
ATOM   3590 C  CG2 . THR   A 1 488 ? -26.901 -53.304 -5.172  1.00 26.01  ? 751  THR   A CG2 1 
ATOM   3591 N  N   . ALA   A 1 489 ? -29.555 -54.142 -7.692  1.00 27.03  ? 752  ALA   A N   1 
ATOM   3592 C  CA  . ALA   A 1 489 ? -29.576 -55.215 -8.713  1.00 25.49  ? 752  ALA   A CA  1 
ATOM   3593 C  C   . ALA   A 1 489 ? -29.629 -54.612 -10.124 1.00 30.53  ? 752  ALA   A C   1 
ATOM   3594 O  O   . ALA   A 1 489 ? -28.899 -55.131 -11.017 1.00 27.58  ? 752  ALA   A O   1 
ATOM   3595 C  CB  . ALA   A 1 489 ? -30.731 -56.152 -8.483  1.00 27.31  ? 752  ALA   A CB  1 
ATOM   3596 N  N   . CYS   A 1 490 ? -30.436 -53.558 -10.334 1.00 27.81  ? 753  CYS   A N   1 
ATOM   3597 C  CA  . CYS   A 1 490 ? -30.590 -52.908 -11.668 1.00 30.04  ? 753  CYS   A CA  1 
ATOM   3598 C  C   . CYS   A 1 490 ? -29.300 -52.173 -12.081 1.00 28.02  ? 753  CYS   A C   1 
ATOM   3599 O  O   . CYS   A 1 490 ? -28.974 -52.159 -13.271 1.00 25.39  ? 753  CYS   A O   1 
ATOM   3600 C  CB  . CYS   A 1 490 ? -31.802 -51.995 -11.702 1.00 29.58  ? 753  CYS   A CB  1 
ATOM   3601 S  SG  . CYS   A 1 490 ? -33.350 -52.949 -11.629 1.00 32.00  ? 753  CYS   A SG  1 
ATOM   3602 N  N   . LEU   A 1 491 ? -28.560 -51.608 -11.146 1.00 26.34  ? 754  LEU   A N   1 
ATOM   3603 C  CA  . LEU   A 1 491 ? -27.205 -51.067 -11.448 1.00 28.27  ? 754  LEU   A CA  1 
ATOM   3604 C  C   . LEU   A 1 491 ? -26.231 -52.195 -11.815 1.00 27.76  ? 754  LEU   A C   1 
ATOM   3605 O  O   . LEU   A 1 491 ? -25.480 -52.048 -12.761 1.00 29.95  ? 754  LEU   A O   1 
ATOM   3606 C  CB  . LEU   A 1 491 ? -26.709 -50.293 -10.231 1.00 31.49  ? 754  LEU   A CB  1 
ATOM   3607 C  CG  . LEU   A 1 491 ? -25.381 -49.558 -10.433 1.00 32.62  ? 754  LEU   A CG  1 
ATOM   3608 C  CD1 . LEU   A 1 491 ? -25.457 -48.617 -11.633 1.00 33.00  ? 754  LEU   A CD1 1 
ATOM   3609 C  CD2 . LEU   A 1 491 ? -24.982 -48.809 -9.165  1.00 31.65  ? 754  LEU   A CD2 1 
ATOM   3610 N  N   . GLY   A 1 492 ? -26.242 -53.303 -11.086 1.00 25.57  ? 755  GLY   A N   1 
ATOM   3611 C  CA  . GLY   A 1 492 ? -25.392 -54.429 -11.447 1.00 23.96  ? 755  GLY   A CA  1 
ATOM   3612 C  C   . GLY   A 1 492 ? -25.673 -54.857 -12.866 1.00 24.75  ? 755  GLY   A C   1 
ATOM   3613 O  O   . GLY   A 1 492 ? -24.739 -55.105 -13.635 1.00 23.95  ? 755  GLY   A O   1 
ATOM   3614 N  N   . LYS   A 1 493 ? -26.951 -54.950 -13.198 1.00 23.34  ? 756  LYS   A N   1 
ATOM   3615 C  CA  . LYS   A 1 493 ? -27.459 -55.353 -14.537 1.00 24.69  ? 756  LYS   A CA  1 
ATOM   3616 C  C   . LYS   A 1 493 ? -26.938 -54.410 -15.614 1.00 23.64  ? 756  LYS   A C   1 
ATOM   3617 O  O   . LYS   A 1 493 ? -26.593 -54.868 -16.681 1.00 25.39  ? 756  LYS   A O   1 
ATOM   3618 C  CB  . LYS   A 1 493 ? -29.005 -55.349 -14.580 1.00 24.70  ? 756  LYS   A CB  1 
ATOM   3619 C  CG  . LYS   A 1 493 ? -29.576 -55.966 -15.848 1.00 26.19  ? 756  LYS   A CG  1 
ATOM   3620 C  CD  . LYS   A 1 493 ? -31.000 -56.438 -15.693 1.00 27.28  ? 756  LYS   A CD  1 
ATOM   3621 C  CE  . LYS   A 1 493 ? -31.648 -56.747 -17.030 1.00 30.32  ? 756  LYS   A CE  1 
ATOM   3622 N  NZ  . LYS   A 1 493 ? -32.969 -57.416 -16.864 1.00 33.29  ? 756  LYS   A NZ  1 
ATOM   3623 N  N   . SER   A 1 494 ? -26.903 -53.108 -15.322 0.48 23.55  ? 757  SER   A N   1 
ATOM   3624 C  CA  . SER   A 1 494 ? -26.378 -52.046 -16.221 0.48 24.54  ? 757  SER   A CA  1 
ATOM   3625 C  C   . SER   A 1 494 ? -24.891 -52.286 -16.518 0.48 25.04  ? 757  SER   A C   1 
ATOM   3626 O  O   . SER   A 1 494 ? -24.501 -52.089 -17.681 0.48 25.00  ? 757  SER   A O   1 
ATOM   3627 C  CB  . SER   A 1 494 ? -26.595 -50.672 -15.637 0.48 24.64  ? 757  SER   A CB  1 
ATOM   3628 O  OG  . SER   A 1 494 ? -27.958 -50.471 -15.291 0.48 23.18  ? 757  SER   A OG  1 
ATOM   3629 N  N   . TYR   A 1 495 ? -24.095 -52.668 -15.511 1.00 24.33  ? 758  TYR   A N   1 
ATOM   3630 C  CA  . TYR   A 1 495 ? -22.653 -53.013 -15.704 1.00 27.98  ? 758  TYR   A CA  1 
ATOM   3631 C  C   . TYR   A 1 495 ? -22.539 -54.294 -16.535 1.00 26.77  ? 758  TYR   A C   1 
ATOM   3632 O  O   . TYR   A 1 495 ? -21.771 -54.336 -17.533 1.00 26.29  ? 758  TYR   A O   1 
ATOM   3633 C  CB  . TYR   A 1 495 ? -21.912 -53.124 -14.371 1.00 27.22  ? 758  TYR   A CB  1 
ATOM   3634 C  CG  . TYR   A 1 495 ? -21.419 -51.790 -13.899 1.00 25.98  ? 758  TYR   A CG  1 
ATOM   3635 C  CD1 . TYR   A 1 495 ? -20.321 -51.202 -14.510 1.00 27.25  ? 758  TYR   A CD1 1 
ATOM   3636 C  CD2 . TYR   A 1 495 ? -22.047 -51.109 -12.874 1.00 26.56  ? 758  TYR   A CD2 1 
ATOM   3637 C  CE1 . TYR   A 1 495 ? -19.884 -49.949 -14.146 1.00 24.89  ? 758  TYR   A CE1 1 
ATOM   3638 C  CE2 . TYR   A 1 495 ? -21.597 -49.859 -12.476 1.00 28.30  ? 758  TYR   A CE2 1 
ATOM   3639 C  CZ  . TYR   A 1 495 ? -20.504 -49.288 -13.110 1.00 29.21  ? 758  TYR   A CZ  1 
ATOM   3640 O  OH  . TYR   A 1 495 ? -20.026 -48.072 -12.729 1.00 30.58  ? 758  TYR   A OH  1 
ATOM   3641 N  N   . ALA   A 1 496 ? -23.352 -55.287 -16.177 1.00 27.34  ? 759  ALA   A N   1 
ATOM   3642 C  CA  . ALA   A 1 496 ? -23.322 -56.597 -16.844 1.00 25.73  ? 759  ALA   A CA  1 
ATOM   3643 C  C   . ALA   A 1 496 ? -23.591 -56.403 -18.343 1.00 26.28  ? 759  ALA   A C   1 
ATOM   3644 O  O   . ALA   A 1 496 ? -22.865 -56.974 -19.173 1.00 25.59  ? 759  ALA   A O   1 
ATOM   3645 C  CB  . ALA   A 1 496 ? -24.312 -57.517 -16.194 1.00 27.26  ? 759  ALA   A CB  1 
ATOM   3646 N  N   . GLN   A 1 497 ? -24.628 -55.629 -18.679 0.48 26.40  ? 760  GLN   A N   1 
ATOM   3647 C  CA  . GLN   A 1 497 ? -25.035 -55.374 -20.092 0.48 27.87  ? 760  GLN   A CA  1 
ATOM   3648 C  C   . GLN   A 1 497 ? -23.906 -54.607 -20.806 0.48 26.69  ? 760  GLN   A C   1 
ATOM   3649 O  O   . GLN   A 1 497 ? -23.593 -54.947 -21.976 0.48 25.83  ? 760  GLN   A O   1 
ATOM   3650 C  CB  . GLN   A 1 497 ? -26.402 -54.679 -20.138 0.48 28.91  ? 760  GLN   A CB  1 
ATOM   3651 C  CG  . GLN   A 1 497 ? -27.510 -55.501 -19.486 0.48 29.57  ? 760  GLN   A CG  1 
ATOM   3652 C  CD  . GLN   A 1 497 ? -28.908 -55.149 -19.938 0.48 29.31  ? 760  GLN   A CD  1 
ATOM   3653 O  OE1 . GLN   A 1 497 ? -29.757 -56.019 -20.107 0.48 29.75  ? 760  GLN   A OE1 1 
ATOM   3654 N  NE2 . GLN   A 1 497 ? -29.161 -53.869 -20.137 0.48 28.60  ? 760  GLN   A NE2 1 
ATOM   3655 N  N   . MET   A 1 498 ? -23.256 -53.659 -20.132 1.00 25.04  ? 761  MET   A N   1 
ATOM   3656 C  CA  . MET   A 1 498 ? -22.125 -52.930 -20.758 1.00 27.19  ? 761  MET   A CA  1 
ATOM   3657 C  C   . MET   A 1 498 ? -21.006 -53.921 -21.110 1.00 24.72  ? 761  MET   A C   1 
ATOM   3658 O  O   . MET   A 1 498 ? -20.490 -53.840 -22.216 1.00 23.86  ? 761  MET   A O   1 
ATOM   3659 C  CB  . MET   A 1 498 ? -21.578 -51.833 -19.845 1.00 30.36  ? 761  MET   A CB  1 
ATOM   3660 C  CG  . MET   A 1 498 ? -20.394 -51.095 -20.428 1.00 34.04  ? 761  MET   A CG  1 
ATOM   3661 S  SD  . MET   A 1 498 ? -19.726 -49.863 -19.291 1.00 37.42  ? 761  MET   A SD  1 
ATOM   3662 C  CE  . MET   A 1 498 ? -19.085 -50.917 -17.994 1.00 38.86  ? 761  MET   A CE  1 
ATOM   3663 N  N   . TRP   A 1 499 ? -20.681 -54.829 -20.195 0.48 25.59  ? 762  TRP   A N   1 
ATOM   3664 C  CA  . TRP   A 1 499 ? -19.601 -55.820 -20.425 0.48 26.08  ? 762  TRP   A CA  1 
ATOM   3665 C  C   . TRP   A 1 499 ? -19.953 -56.740 -21.595 0.48 27.77  ? 762  TRP   A C   1 
ATOM   3666 O  O   . TRP   A 1 499 ? -19.119 -56.855 -22.502 0.48 26.55  ? 762  TRP   A O   1 
ATOM   3667 C  CB  . TRP   A 1 499 ? -19.374 -56.634 -19.147 0.48 26.32  ? 762  TRP   A CB  1 
ATOM   3668 C  CG  . TRP   A 1 499 ? -18.798 -55.872 -17.995 0.48 25.76  ? 762  TRP   A CG  1 
ATOM   3669 C  CD1 . TRP   A 1 499 ? -18.325 -54.593 -17.997 0.48 25.74  ? 762  TRP   A CD1 1 
ATOM   3670 C  CD2 . TRP   A 1 499 ? -18.619 -56.363 -16.656 0.48 25.76  ? 762  TRP   A CD2 1 
ATOM   3671 N  NE1 . TRP   A 1 499 ? -17.873 -54.253 -16.751 0.48 25.17  ? 762  TRP   A NE1 1 
ATOM   3672 C  CE2 . TRP   A 1 499 ? -18.039 -55.318 -15.908 0.48 24.42  ? 762  TRP   A CE2 1 
ATOM   3673 C  CE3 . TRP   A 1 499 ? -18.896 -57.577 -16.018 0.48 25.41  ? 762  TRP   A CE3 1 
ATOM   3674 C  CZ2 . TRP   A 1 499 ? -17.731 -55.456 -14.557 0.48 25.06  ? 762  TRP   A CZ2 1 
ATOM   3675 C  CZ3 . TRP   A 1 499 ? -18.592 -57.711 -14.682 0.48 25.19  ? 762  TRP   A CZ3 1 
ATOM   3676 C  CH2 . TRP   A 1 499 ? -18.017 -56.663 -13.964 0.48 25.32  ? 762  TRP   A CH2 1 
ATOM   3677 N  N   A SER   A 1 500 ? -21.234 -57.098 -21.722 0.24 27.02  ? 763  SER   A N   1 
ATOM   3678 N  N   B SER   A 1 500 ? -21.233 -57.103 -21.719 0.25 26.52  ? 763  SER   A N   1 
ATOM   3679 C  CA  A SER   A 1 500 ? -21.666 -58.030 -22.798 0.24 26.91  ? 763  SER   A CA  1 
ATOM   3680 C  CA  B SER   A 1 500 ? -21.664 -58.033 -22.798 0.25 26.20  ? 763  SER   A CA  1 
ATOM   3681 C  C   A SER   A 1 500 ? -21.561 -57.368 -24.171 0.24 26.11  ? 763  SER   A C   1 
ATOM   3682 C  C   B SER   A 1 500 ? -21.562 -57.368 -24.172 0.25 25.66  ? 763  SER   A C   1 
ATOM   3683 O  O   A SER   A 1 500 ? -21.104 -58.046 -25.106 0.24 27.40  ? 763  SER   A O   1 
ATOM   3684 O  O   B SER   A 1 500 ? -21.107 -58.046 -25.107 0.25 27.11  ? 763  SER   A O   1 
ATOM   3685 C  CB  A SER   A 1 500 ? -23.074 -58.494 -22.549 0.24 28.45  ? 763  SER   A CB  1 
ATOM   3686 C  CB  B SER   A 1 500 ? -23.064 -58.533 -22.547 0.25 27.30  ? 763  SER   A CB  1 
ATOM   3687 O  OG  A SER   A 1 500 ? -23.251 -58.841 -21.185 0.24 29.66  ? 763  SER   A OG  1 
ATOM   3688 O  OG  B SER   A 1 500 ? -24.003 -57.473 -22.629 0.25 27.90  ? 763  SER   A OG  1 
ATOM   3689 N  N   . LEU   A 1 501 ? -21.686 -56.040 -24.217 0.48 26.72  ? 764  LEU   A N   1 
ATOM   3690 C  CA  . LEU   A 1 501 ? -21.670 -55.328 -25.521 0.48 26.70  ? 764  LEU   A CA  1 
ATOM   3691 C  C   . LEU   A 1 501 ? -20.277 -54.807 -25.865 0.48 26.32  ? 764  LEU   A C   1 
ATOM   3692 O  O   . LEU   A 1 501 ? -19.913 -54.903 -27.040 0.48 26.00  ? 764  LEU   A O   1 
ATOM   3693 C  CB  . LEU   A 1 501 ? -22.655 -54.160 -25.405 0.48 27.83  ? 764  LEU   A CB  1 
ATOM   3694 C  CG  . LEU   A 1 501 ? -23.032 -53.471 -26.714 0.48 29.27  ? 764  LEU   A CG  1 
ATOM   3695 C  CD1 . LEU   A 1 501 ? -23.575 -54.473 -27.719 0.48 31.33  ? 764  LEU   A CD1 1 
ATOM   3696 C  CD2 . LEU   A 1 501 ? -24.040 -52.361 -26.465 0.48 29.93  ? 764  LEU   A CD2 1 
ATOM   3697 N  N   . MET   A 1 502 ? -19.498 -54.390 -24.875 0.48 25.87  ? 765  MET   A N   1 
ATOM   3698 C  CA  . MET   A 1 502 ? -18.225 -53.668 -25.129 0.48 25.53  ? 765  MET   A CA  1 
ATOM   3699 C  C   . MET   A 1 502 ? -16.999 -54.508 -24.741 0.48 25.32  ? 765  MET   A C   1 
ATOM   3700 O  O   . MET   A 1 502 ? -15.936 -54.260 -25.323 0.48 23.81  ? 765  MET   A O   1 
ATOM   3701 C  CB  . MET   A 1 502 ? -18.204 -52.355 -24.340 0.48 27.06  ? 765  MET   A CB  1 
ATOM   3702 C  CG  . MET   A 1 502 ? -19.280 -51.375 -24.766 0.48 26.51  ? 765  MET   A CG  1 
ATOM   3703 S  SD  . MET   A 1 502 ? -19.157 -50.923 -26.516 0.48 28.04  ? 765  MET   A SD  1 
ATOM   3704 C  CE  . MET   A 1 502 ? -20.086 -52.261 -27.261 0.48 30.99  ? 765  MET   A CE  1 
ATOM   3705 N  N   . TYR   A 1 503 ? -17.126 -55.414 -23.769 1.00 23.92  ? 766  TYR   A N   1 
ATOM   3706 C  CA  . TYR   A 1 503 ? -15.999 -56.206 -23.230 1.00 24.78  ? 766  TYR   A CA  1 
ATOM   3707 C  C   . TYR   A 1 503 ? -16.250 -57.720 -23.357 1.00 25.18  ? 766  TYR   A C   1 
ATOM   3708 O  O   . TYR   A 1 503 ? -15.658 -58.472 -22.562 1.00 24.52  ? 766  TYR   A O   1 
ATOM   3709 C  CB  . TYR   A 1 503 ? -15.760 -55.771 -21.779 1.00 25.71  ? 766  TYR   A CB  1 
ATOM   3710 C  CG  . TYR   A 1 503 ? -15.573 -54.278 -21.576 1.00 24.96  ? 766  TYR   A CG  1 
ATOM   3711 C  CD1 . TYR   A 1 503 ? -14.572 -53.576 -22.229 1.00 26.35  ? 766  TYR   A CD1 1 
ATOM   3712 C  CD2 . TYR   A 1 503 ? -16.369 -53.554 -20.712 1.00 27.11  ? 766  TYR   A CD2 1 
ATOM   3713 C  CE1 . TYR   A 1 503 ? -14.416 -52.205 -22.072 1.00 25.36  ? 766  TYR   A CE1 1 
ATOM   3714 C  CE2 . TYR   A 1 503 ? -16.244 -52.176 -20.561 1.00 27.24  ? 766  TYR   A CE2 1 
ATOM   3715 C  CZ  . TYR   A 1 503 ? -15.230 -51.503 -21.214 1.00 26.48  ? 766  TYR   A CZ  1 
ATOM   3716 O  OH  . TYR   A 1 503 ? -15.036 -50.171 -21.055 1.00 26.67  ? 766  TYR   A OH  1 
ATOM   3717 N  N   . PHE   A 1 504 ? -17.026 -58.151 -24.366 1.00 25.85  ? 767  PHE   A N   1 
ATOM   3718 C  CA  . PHE   A 1 504 ? -17.497 -59.549 -24.592 1.00 27.97  ? 767  PHE   A CA  1 
ATOM   3719 C  C   . PHE   A 1 504 ? -16.280 -60.461 -24.800 1.00 28.05  ? 767  PHE   A C   1 
ATOM   3720 O  O   . PHE   A 1 504 ? -16.306 -61.713 -24.552 1.00 24.42  ? 767  PHE   A O   1 
ATOM   3721 C  CB  . PHE   A 1 504 ? -18.407 -59.635 -25.828 1.00 23.89  ? 767  PHE   A CB  1 
ATOM   3722 C  CG  . PHE   A 1 504 ? -17.901 -58.888 -27.047 1.00 22.74  ? 767  PHE   A CG  1 
ATOM   3723 C  CD1 . PHE   A 1 504 ? -18.250 -57.579 -27.275 1.00 24.39  ? 767  PHE   A CD1 1 
ATOM   3724 C  CD2 . PHE   A 1 504 ? -17.099 -59.500 -27.982 1.00 22.28  ? 767  PHE   A CD2 1 
ATOM   3725 C  CE1 . PHE   A 1 504 ? -17.758 -56.896 -28.376 1.00 24.96  ? 767  PHE   A CE1 1 
ATOM   3726 C  CE2 . PHE   A 1 504 ? -16.574 -58.802 -29.055 1.00 21.60  ? 767  PHE   A CE2 1 
ATOM   3727 C  CZ  . PHE   A 1 504 ? -16.932 -57.508 -29.267 1.00 24.69  ? 767  PHE   A CZ  1 
ATOM   3728 N  N   . HIS   A 1 505 ? -15.234 -59.834 -25.323 1.00 26.35  ? 768  HIS   A N   1 
ATOM   3729 C  CA  . HIS   A 1 505 ? -13.953 -60.494 -25.713 1.00 27.43  ? 768  HIS   A CA  1 
ATOM   3730 C  C   . HIS   A 1 505 ? -13.079 -60.853 -24.494 1.00 25.79  ? 768  HIS   A C   1 
ATOM   3731 O  O   . HIS   A 1 505 ? -12.013 -61.458 -24.698 1.00 28.70  ? 768  HIS   A O   1 
ATOM   3732 C  CB  . HIS   A 1 505 ? -13.231 -59.580 -26.699 1.00 25.25  ? 768  HIS   A CB  1 
ATOM   3733 C  CG  . HIS   A 1 505 ? -13.078 -58.185 -26.205 1.00 24.77  ? 768  HIS   A CG  1 
ATOM   3734 N  ND1 . HIS   A 1 505 ? -12.032 -57.799 -25.409 1.00 24.48  ? 768  HIS   A ND1 1 
ATOM   3735 C  CD2 . HIS   A 1 505 ? -13.846 -57.090 -26.388 1.00 27.93  ? 768  HIS   A CD2 1 
ATOM   3736 C  CE1 . HIS   A 1 505 ? -12.159 -56.520 -25.118 1.00 27.69  ? 768  HIS   A CE1 1 
ATOM   3737 N  NE2 . HIS   A 1 505 ? -13.264 -56.045 -25.725 1.00 24.46  ? 768  HIS   A NE2 1 
ATOM   3738 N  N   . ARG   A 1 506 ? -13.443 -60.423 -23.278 1.00 23.18  ? 769  ARG   A N   1 
ATOM   3739 C  CA  . ARG   A 1 506 ? -12.724 -60.758 -22.023 1.00 22.22  ? 769  ARG   A CA  1 
ATOM   3740 C  C   . ARG   A 1 506 ? -13.488 -61.931 -21.394 1.00 26.98  ? 769  ARG   A C   1 
ATOM   3741 O  O   . ARG   A 1 506 ? -14.729 -61.775 -21.162 1.00 26.79  ? 769  ARG   A O   1 
ATOM   3742 C  CB  . ARG   A 1 506 ? -12.631 -59.551 -21.082 1.00 22.99  ? 769  ARG   A CB  1 
ATOM   3743 C  CG  . ARG   A 1 506 ? -12.155 -58.248 -21.717 1.00 22.24  ? 769  ARG   A CG  1 
ATOM   3744 C  CD  . ARG   A 1 506 ? -10.797 -58.289 -22.433 1.00 22.96  ? 769  ARG   A CD  1 
ATOM   3745 N  NE  . ARG   A 1 506 ? -9.862  -58.864 -21.484 1.00 23.37  ? 769  ARG   A NE  1 
ATOM   3746 C  CZ  . ARG   A 1 506 ? -9.370  -58.248 -20.428 1.00 22.71  ? 769  ARG   A CZ  1 
ATOM   3747 N  NH1 . ARG   A 1 506 ? -8.671  -58.940 -19.548 1.00 23.34  ? 769  ARG   A NH1 1 
ATOM   3748 N  NH2 . ARG   A 1 506 ? -9.505  -56.947 -20.265 1.00 23.69  ? 769  ARG   A NH2 1 
ATOM   3749 N  N   . ARG   A 1 507 ? -12.843 -63.091 -21.254 1.00 25.25  ? 770  ARG   A N   1 
ATOM   3750 C  CA  . ARG   A 1 507 ? -13.496 -64.343 -20.817 1.00 25.20  ? 770  ARG   A CA  1 
ATOM   3751 C  C   . ARG   A 1 507 ? -14.163 -64.114 -19.463 1.00 24.36  ? 770  ARG   A C   1 
ATOM   3752 O  O   . ARG   A 1 507 ? -15.325 -64.498 -19.346 1.00 24.73  ? 770  ARG   A O   1 
ATOM   3753 C  CB  . ARG   A 1 507 ? -12.494 -65.488 -20.729 1.00 26.59  ? 770  ARG   A CB  1 
ATOM   3754 C  CG  . ARG   A 1 507 ? -11.960 -65.948 -22.073 1.00 30.21  ? 770  ARG   A CG  1 
ATOM   3755 C  CD  . ARG   A 1 507 ? -10.663 -66.746 -21.888 1.00 29.59  ? 770  ARG   A CD  1 
ATOM   3756 N  NE  . ARG   A 1 507 ? -10.281 -67.271 -23.176 1.00 28.63  ? 770  ARG   A NE  1 
ATOM   3757 C  CZ  . ARG   A 1 507 ? -9.676  -66.556 -24.096 1.00 29.97  ? 770  ARG   A CZ  1 
ATOM   3758 N  NH1 . ARG   A 1 507 ? -9.384  -65.290 -23.837 1.00 27.64  ? 770  ARG   A NH1 1 
ATOM   3759 N  NH2 . ARG   A 1 507 ? -9.373  -67.092 -25.265 1.00 29.75  ? 770  ARG   A NH2 1 
ATOM   3760 N  N   . ASP   A 1 508 ? -13.512 -63.450 -18.504 1.00 22.95  ? 771  ASP   A N   1 
ATOM   3761 C  CA  . ASP   A 1 508 ? -14.075 -63.292 -17.131 1.00 24.94  ? 771  ASP   A CA  1 
ATOM   3762 C  C   . ASP   A 1 508 ? -15.333 -62.389 -17.159 1.00 25.87  ? 771  ASP   A C   1 
ATOM   3763 O  O   . ASP   A 1 508 ? -16.294 -62.608 -16.380 1.00 24.19  ? 771  ASP   A O   1 
ATOM   3764 C  CB  . ASP   A 1 508 ? -13.037 -62.747 -16.156 1.00 25.50  ? 771  ASP   A CB  1 
ATOM   3765 C  CG  . ASP   A 1 508 ? -11.821 -63.632 -15.956 1.00 25.51  ? 771  ASP   A CG  1 
ATOM   3766 O  OD1 . ASP   A 1 508 ? -11.876 -64.820 -16.352 1.00 23.46  ? 771  ASP   A OD1 1 
ATOM   3767 O  OD2 . ASP   A 1 508 ? -10.856 -63.131 -15.351 1.00 22.92  ? 771  ASP   A OD2 1 
ATOM   3768 N  N   . LEU   A 1 509 ? -15.342 -61.373 -18.009 1.00 26.75  ? 772  LEU   A N   1 
ATOM   3769 C  CA  . LEU   A 1 509 ? -16.429 -60.366 -18.030 1.00 26.24  ? 772  LEU   A CA  1 
ATOM   3770 C  C   . LEU   A 1 509 ? -17.618 -60.961 -18.769 1.00 25.21  ? 772  LEU   A C   1 
ATOM   3771 O  O   . LEU   A 1 509 ? -18.698 -60.682 -18.346 1.00 26.38  ? 772  LEU   A O   1 
ATOM   3772 C  CB  . LEU   A 1 509 ? -15.920 -59.061 -18.657 1.00 25.26  ? 772  LEU   A CB  1 
ATOM   3773 C  CG  . LEU   A 1 509 ? -14.825 -58.330 -17.860 1.00 25.57  ? 772  LEU   A CG  1 
ATOM   3774 C  CD1 . LEU   A 1 509 ? -14.642 -56.897 -18.386 1.00 25.52  ? 772  LEU   A CD1 1 
ATOM   3775 C  CD2 . LEU   A 1 509 ? -15.122 -58.330 -16.354 1.00 23.41  ? 772  LEU   A CD2 1 
ATOM   3776 N  N   . ARG   A 1 510 ? -17.422 -61.806 -19.795 1.00 28.33  ? 773  ARG   A N   1 
ATOM   3777 C  CA  . ARG   A 1 510 ? -18.590 -62.418 -20.495 1.00 26.64  ? 773  ARG   A CA  1 
ATOM   3778 C  C   . ARG   A 1 510 ? -19.259 -63.384 -19.503 1.00 27.81  ? 773  ARG   A C   1 
ATOM   3779 O  O   . ARG   A 1 510 ? -20.517 -63.460 -19.484 1.00 26.16  ? 773  ARG   A O   1 
ATOM   3780 C  CB  . ARG   A 1 510 ? -18.237 -63.119 -21.809 1.00 26.82  ? 773  ARG   A CB  1 
ATOM   3781 C  CG  . ARG   A 1 510 ? -19.460 -63.483 -22.655 1.00 28.28  ? 773  ARG   A CG  1 
ATOM   3782 C  CD  . ARG   A 1 510 ? -19.249 -64.331 -23.888 1.00 27.85  ? 773  ARG   A CD  1 
ATOM   3783 N  NE  . ARG   A 1 510 ? -18.319 -63.732 -24.834 1.00 28.43  ? 773  ARG   A NE  1 
ATOM   3784 C  CZ  . ARG   A 1 510 ? -18.110 -64.145 -26.094 1.00 29.69  ? 773  ARG   A CZ  1 
ATOM   3785 N  NH1 . ARG   A 1 510 ? -18.849 -65.107 -26.602 1.00 32.85  ? 773  ARG   A NH1 1 
ATOM   3786 N  NH2 . ARG   A 1 510 ? -17.219 -63.546 -26.874 1.00 29.37  ? 773  ARG   A NH2 1 
ATOM   3787 N  N   . LEU   A 1 511 ? -18.466 -64.064 -18.675 1.00 23.64  ? 774  LEU   A N   1 
ATOM   3788 C  CA  . LEU   A 1 511 ? -18.995 -65.070 -17.719 1.00 25.98  ? 774  LEU   A CA  1 
ATOM   3789 C  C   . LEU   A 1 511 ? -19.654 -64.329 -16.558 1.00 25.29  ? 774  LEU   A C   1 
ATOM   3790 O  O   . LEU   A 1 511 ? -20.787 -64.662 -16.194 1.00 25.26  ? 774  LEU   A O   1 
ATOM   3791 C  CB  . LEU   A 1 511 ? -17.871 -66.007 -17.261 1.00 29.89  ? 774  LEU   A CB  1 
ATOM   3792 C  CG  . LEU   A 1 511 ? -18.333 -67.287 -16.555 1.00 32.20  ? 774  LEU   A CG  1 
ATOM   3793 C  CD1 . LEU   A 1 511 ? -17.212 -68.276 -16.450 1.00 31.45  ? 774  LEU   A CD1 1 
ATOM   3794 C  CD2 . LEU   A 1 511 ? -18.883 -67.016 -15.165 1.00 33.29  ? 774  LEU   A CD2 1 
ATOM   3795 N  N   . ALA   A 1 512 ? -19.051 -63.271 -16.065 1.00 24.54  ? 775  ALA   A N   1 
ATOM   3796 C  CA  . ALA   A 1 512 ? -19.642 -62.538 -14.932 1.00 23.74  ? 775  ALA   A CA  1 
ATOM   3797 C  C   . ALA   A 1 512 ? -20.937 -61.837 -15.404 1.00 24.68  ? 775  ALA   A C   1 
ATOM   3798 O  O   . ALA   A 1 512 ? -21.880 -61.717 -14.611 1.00 23.27  ? 775  ALA   A O   1 
ATOM   3799 C  CB  . ALA   A 1 512 ? -18.610 -61.579 -14.393 1.00 22.02  ? 775  ALA   A CB  1 
ATOM   3800 N  N   . ALA   A 1 513 ? -20.972 -61.331 -16.632 1.00 24.95  ? 776  ALA   A N   1 
ATOM   3801 C  CA  . ALA   A 1 513 ? -22.133 -60.586 -17.170 1.00 26.77  ? 776  ALA   A CA  1 
ATOM   3802 C  C   . ALA   A 1 513 ? -23.312 -61.561 -17.305 1.00 26.92  ? 776  ALA   A C   1 
ATOM   3803 O  O   . ALA   A 1 513 ? -24.451 -61.207 -16.925 1.00 26.35  ? 776  ALA   A O   1 
ATOM   3804 C  CB  . ALA   A 1 513 ? -21.783 -59.903 -18.484 1.00 24.96  ? 776  ALA   A CB  1 
ATOM   3805 N  N   . ASN   A 1 514 ? -23.043 -62.757 -17.826 1.00 27.58  ? 777  ASN   A N   1 
ATOM   3806 C  CA  . ASN   A 1 514 ? -24.067 -63.818 -17.963 1.00 28.53  ? 777  ASN   A CA  1 
ATOM   3807 C  C   . ASN   A 1 514 ? -24.572 -64.181 -16.572 1.00 28.59  ? 777  ASN   A C   1 
ATOM   3808 O  O   . ASN   A 1 514 ? -25.815 -64.345 -16.400 1.00 26.79  ? 777  ASN   A O   1 
ATOM   3809 C  CB  . ASN   A 1 514 ? -23.531 -65.032 -18.707 1.00 28.21  ? 777  ASN   A CB  1 
ATOM   3810 C  CG  . ASN   A 1 514 ? -23.430 -64.752 -20.187 1.00 31.06  ? 777  ASN   A CG  1 
ATOM   3811 O  OD1 . ASN   A 1 514 ? -24.211 -63.974 -20.707 1.00 31.45  ? 777  ASN   A OD1 1 
ATOM   3812 N  ND2 . ASN   A 1 514 ? -22.440 -65.322 -20.865 1.00 33.71  ? 777  ASN   A ND2 1 
ATOM   3813 N  N   . ALA   A 1 515 ? -23.671 -64.270 -15.604 1.00 26.37  ? 778  ALA   A N   1 
ATOM   3814 C  CA  . ALA   A 1 515 ? -24.043 -64.647 -14.226 1.00 25.47  ? 778  ALA   A CA  1 
ATOM   3815 C  C   . ALA   A 1 515 ? -24.898 -63.524 -13.630 1.00 26.52  ? 778  ALA   A C   1 
ATOM   3816 O  O   . ALA   A 1 515 ? -25.919 -63.811 -13.027 1.00 24.81  ? 778  ALA   A O   1 
ATOM   3817 C  CB  . ALA   A 1 515 ? -22.835 -64.945 -13.378 1.00 22.68  ? 778  ALA   A CB  1 
ATOM   3818 N  N   . ILE   A 1 516 ? -24.492 -62.267 -13.747 1.00 25.56  ? 779  ILE   A N   1 
ATOM   3819 C  CA  . ILE   A 1 516 ? -25.315 -61.166 -13.166 1.00 25.79  ? 779  ILE   A CA  1 
ATOM   3820 C  C   . ILE   A 1 516 ? -26.700 -61.135 -13.854 1.00 28.41  ? 779  ILE   A C   1 
ATOM   3821 O  O   . ILE   A 1 516 ? -27.680 -61.033 -13.131 1.00 27.45  ? 779  ILE   A O   1 
ATOM   3822 C  CB  . ILE   A 1 516 ? -24.607 -59.804 -13.240 1.00 22.75  ? 779  ILE   A CB  1 
ATOM   3823 C  CG1 . ILE   A 1 516 ? -23.330 -59.803 -12.416 1.00 24.57  ? 779  ILE   A CG1 1 
ATOM   3824 C  CG2 . ILE   A 1 516 ? -25.516 -58.643 -12.826 1.00 23.70  ? 779  ILE   A CG2 1 
ATOM   3825 C  CD1 . ILE   A 1 516 ? -22.355 -58.721 -12.863 1.00 26.16  ? 779  ILE   A CD1 1 
ATOM   3826 N  N   . CYS   A 1 517 ? -26.784 -61.175 -15.185 1.00 28.21  ? 780  CYS   A N   1 
ATOM   3827 C  CA  . CYS   A 1 517 ? -28.069 -61.160 -15.919 1.00 27.81  ? 780  CYS   A CA  1 
ATOM   3828 C  C   . CYS   A 1 517 ? -28.914 -62.394 -15.566 1.00 30.38  ? 780  CYS   A C   1 
ATOM   3829 O  O   . CYS   A 1 517 ? -30.137 -62.294 -15.683 1.00 29.86  ? 780  CYS   A O   1 
ATOM   3830 C  CB  . CYS   A 1 517 ? -27.845 -61.028 -17.413 1.00 26.77  ? 780  CYS   A CB  1 
ATOM   3831 S  SG  . CYS   A 1 517 ? -27.177 -59.394 -17.811 1.00 30.80  ? 780  CYS   A SG  1 
ATOM   3832 N  N   . SER   A 1 518 ? -28.302 -63.497 -15.127 1.00 28.42  ? 781  SER   A N   1 
ATOM   3833 C  CA  . SER   A 1 518 ? -29.022 -64.708 -14.671 1.00 29.05  ? 781  SER   A CA  1 
ATOM   3834 C  C   . SER   A 1 518 ? -29.559 -64.498 -13.246 1.00 31.54  ? 781  SER   A C   1 
ATOM   3835 O  O   . SER   A 1 518 ? -30.612 -65.075 -12.926 1.00 31.49  ? 781  SER   A O   1 
ATOM   3836 C  CB  . SER   A 1 518 ? -28.164 -65.961 -14.767 1.00 28.37  ? 781  SER   A CB  1 
ATOM   3837 O  OG  . SER   A 1 518 ? -27.885 -66.286 -16.118 1.00 29.77  ? 781  SER   A OG  1 
ATOM   3838 N  N   . ALA   A 1 519 ? -28.866 -63.695 -12.436 1.00 31.05  ? 782  ALA   A N   1 
ATOM   3839 C  CA  . ALA   A 1 519 ? -29.143 -63.509 -10.994 1.00 32.47  ? 782  ALA   A CA  1 
ATOM   3840 C  C   . ALA   A 1 519 ? -30.186 -62.406 -10.766 1.00 30.16  ? 782  ALA   A C   1 
ATOM   3841 O  O   . ALA   A 1 519 ? -30.737 -62.381 -9.699  1.00 31.07  ? 782  ALA   A O   1 
ATOM   3842 C  CB  . ALA   A 1 519 ? -27.864 -63.233 -10.228 1.00 31.74  ? 782  ALA   A CB  1 
ATOM   3843 N  N   . VAL   A 1 520 ? -30.345 -61.506 -11.724 1.00 29.25  ? 783  VAL   A N   1 
ATOM   3844 C  CA  . VAL   A 1 520 ? -31.293 -60.370 -11.598 1.00 29.62  ? 783  VAL   A CA  1 
ATOM   3845 C  C   . VAL   A 1 520 ? -32.552 -60.683 -12.416 1.00 29.34  ? 783  VAL   A C   1 
ATOM   3846 O  O   . VAL   A 1 520 ? -32.421 -61.172 -13.540 1.00 28.77  ? 783  VAL   A O   1 
ATOM   3847 C  CB  . VAL   A 1 520 ? -30.627 -59.057 -12.047 1.00 29.23  ? 783  VAL   A CB  1 
ATOM   3848 C  CG1 . VAL   A 1 520 ? -31.598 -57.888 -12.035 1.00 30.24  ? 783  VAL   A CG1 1 
ATOM   3849 C  CG2 . VAL   A 1 520 ? -29.385 -58.737 -11.232 1.00 29.51  ? 783  VAL   A CG2 1 
ATOM   3850 N  N   . PRO   A 1 521 ? -33.762 -60.413 -11.884 1.00 29.25  ? 784  PRO   A N   1 
ATOM   3851 C  CA  . PRO   A 1 521 ? -34.995 -60.720 -12.603 1.00 30.86  ? 784  PRO   A CA  1 
ATOM   3852 C  C   . PRO   A 1 521 ? -34.864 -60.324 -14.081 1.00 29.91  ? 784  PRO   A C   1 
ATOM   3853 O  O   . PRO   A 1 521 ? -34.622 -59.168 -14.319 1.00 31.29  ? 784  PRO   A O   1 
ATOM   3854 C  CB  . PRO   A 1 521 ? -36.046 -59.993 -11.757 1.00 30.92  ? 784  PRO   A CB  1 
ATOM   3855 C  CG  . PRO   A 1 521 ? -35.489 -60.085 -10.362 1.00 33.28  ? 784  PRO   A CG  1 
ATOM   3856 C  CD  . PRO   A 1 521 ? -34.006 -59.860 -10.553 1.00 29.45  ? 784  PRO   A CD  1 
ATOM   3857 N  N   A SER   A 1 522 ? -35.351 -61.176 -14.987 0.18 30.40  ? 785  SER   A N   1 
ATOM   3858 N  N   B SER   A 1 522 ? -35.356 -61.174 -14.986 0.18 29.63  ? 785  SER   A N   1 
ATOM   3859 C  CA  A SER   A 1 522 ? -35.207 -60.910 -16.446 0.18 31.17  ? 785  SER   A CA  1 
ATOM   3860 C  CA  B SER   A 1 522 ? -35.208 -60.910 -16.445 0.18 29.93  ? 785  SER   A CA  1 
ATOM   3861 C  C   A SER   A 1 522 ? -35.781 -59.555 -16.873 0.18 31.92  ? 785  SER   A C   1 
ATOM   3862 C  C   B SER   A 1 522 ? -35.782 -59.557 -16.875 0.18 31.19  ? 785  SER   A C   1 
ATOM   3863 O  O   A SER   A 1 522 ? -35.212 -58.966 -17.809 0.18 31.23  ? 785  SER   A O   1 
ATOM   3864 O  O   B SER   A 1 522 ? -35.213 -58.969 -17.811 0.18 30.49  ? 785  SER   A O   1 
ATOM   3865 C  CB  A SER   A 1 522 ? -35.841 -62.029 -17.233 0.18 31.81  ? 785  SER   A CB  1 
ATOM   3866 C  CB  B SER   A 1 522 ? -35.854 -62.024 -17.225 0.18 29.76  ? 785  SER   A CB  1 
ATOM   3867 O  OG  A SER   A 1 522 ? -37.218 -62.154 -16.911 0.18 33.54  ? 785  SER   A OG  1 
ATOM   3868 O  OG  B SER   A 1 522 ? -35.495 -63.287 -16.686 0.18 29.24  ? 785  SER   A OG  1 
ATOM   3869 N  N   . HIS   A 1 523 ? -36.995 -59.226 -16.424 1.00 31.45  ? 786  HIS   A N   1 
ATOM   3870 C  CA  . HIS   A 1 523 ? -37.654 -57.964 -16.874 1.00 31.52  ? 786  HIS   A CA  1 
ATOM   3871 C  C   . HIS   A 1 523 ? -37.268 -56.716 -16.067 1.00 30.87  ? 786  HIS   A C   1 
ATOM   3872 O  O   . HIS   A 1 523 ? -37.738 -55.642 -16.436 1.00 32.87  ? 786  HIS   A O   1 
ATOM   3873 C  CB  . HIS   A 1 523 ? -39.168 -58.191 -16.910 1.00 33.07  ? 786  HIS   A CB  1 
ATOM   3874 C  CG  . HIS   A 1 523 ? -39.558 -59.375 -17.724 1.00 36.02  ? 786  HIS   A CG  1 
ATOM   3875 N  ND1 . HIS   A 1 523 ? -39.659 -59.322 -19.095 1.00 35.12  ? 786  HIS   A ND1 1 
ATOM   3876 C  CD2 . HIS   A 1 523 ? -39.854 -60.641 -17.370 1.00 42.80  ? 786  HIS   A CD2 1 
ATOM   3877 C  CE1 . HIS   A 1 523 ? -40.011 -60.503 -19.551 1.00 41.62  ? 786  HIS   A CE1 1 
ATOM   3878 N  NE2 . HIS   A 1 523 ? -40.138 -61.328 -18.514 1.00 41.85  ? 786  HIS   A NE2 1 
ATOM   3879 N  N   . TRP   A 1 524 ? -36.430 -56.839 -15.041 1.00 30.65  ? 787  TRP   A N   1 
ATOM   3880 C  CA  . TRP   A 1 524 ? -35.995 -55.625 -14.303 1.00 29.34  ? 787  TRP   A CA  1 
ATOM   3881 C  C   . TRP   A 1 524 ? -35.157 -54.721 -15.214 1.00 32.64  ? 787  TRP   A C   1 
ATOM   3882 O  O   . TRP   A 1 524 ? -34.307 -55.240 -15.934 1.00 33.82  ? 787  TRP   A O   1 
ATOM   3883 C  CB  . TRP   A 1 524 ? -35.343 -55.972 -12.960 1.00 31.49  ? 787  TRP   A CB  1 
ATOM   3884 C  CG  . TRP   A 1 524 ? -36.339 -56.431 -11.940 1.00 34.24  ? 787  TRP   A CG  1 
ATOM   3885 C  CD1 . TRP   A 1 524 ? -37.660 -56.698 -12.152 1.00 35.24  ? 787  TRP   A CD1 1 
ATOM   3886 C  CD2 . TRP   A 1 524 ? -36.106 -56.675 -10.541 1.00 31.72  ? 787  TRP   A CD2 1 
ATOM   3887 N  NE1 . TRP   A 1 524 ? -38.261 -57.093 -10.990 1.00 32.69  ? 787  TRP   A NE1 1 
ATOM   3888 C  CE2 . TRP   A 1 524 ? -37.334 -57.088 -9.984  1.00 33.18  ? 787  TRP   A CE2 1 
ATOM   3889 C  CE3 . TRP   A 1 524 ? -34.986 -56.589 -9.709  1.00 33.22  ? 787  TRP   A CE3 1 
ATOM   3890 C  CZ2 . TRP   A 1 524 ? -37.469 -57.414 -8.637  1.00 32.69  ? 787  TRP   A CZ2 1 
ATOM   3891 C  CZ3 . TRP   A 1 524 ? -35.121 -56.912 -8.379  1.00 33.35  ? 787  TRP   A CZ3 1 
ATOM   3892 C  CH2 . TRP   A 1 524 ? -36.345 -57.318 -7.852  1.00 32.77  ? 787  TRP   A CH2 1 
ATOM   3893 N  N   . VAL   A 1 525 ? -35.386 -53.418 -15.143 1.00 30.83  ? 788  VAL   A N   1 
ATOM   3894 C  CA  . VAL   A 1 525 ? -34.775 -52.449 -16.074 1.00 34.84  ? 788  VAL   A CA  1 
ATOM   3895 C  C   . VAL   A 1 525 ? -33.445 -51.959 -15.483 1.00 33.78  ? 788  VAL   A C   1 
ATOM   3896 O  O   . VAL   A 1 525 ? -33.364 -51.441 -14.373 1.00 33.97  ? 788  VAL   A O   1 
ATOM   3897 C  CB  . VAL   A 1 525 ? -35.753 -51.286 -16.349 1.00 35.28  ? 788  VAL   A CB  1 
ATOM   3898 C  CG1 . VAL   A 1 525 ? -35.124 -50.227 -17.260 1.00 35.77  ? 788  VAL   A CG1 1 
ATOM   3899 C  CG2 . VAL   A 1 525 ? -37.110 -51.735 -16.909 1.00 34.80  ? 788  VAL   A CG2 1 
ATOM   3900 N  N   . PRO   A 1 526 ? -32.358 -51.995 -16.259 1.00 36.86  ? 789  PRO   A N   1 
ATOM   3901 C  CA  . PRO   A 1 526 ? -31.095 -51.365 -15.848 1.00 37.50  ? 789  PRO   A CA  1 
ATOM   3902 C  C   . PRO   A 1 526 ? -31.213 -49.851 -15.563 1.00 41.23  ? 789  PRO   A C   1 
ATOM   3903 O  O   . PRO   A 1 526 ? -31.935 -49.191 -16.295 1.00 36.32  ? 789  PRO   A O   1 
ATOM   3904 C  CB  . PRO   A 1 526 ? -30.217 -51.538 -17.087 1.00 37.32  ? 789  PRO   A CB  1 
ATOM   3905 C  CG  . PRO   A 1 526 ? -30.876 -52.556 -17.964 1.00 38.30  ? 789  PRO   A CG  1 
ATOM   3906 C  CD  . PRO   A 1 526 ? -32.336 -52.598 -17.594 1.00 37.96  ? 789  PRO   A CD  1 
ATOM   3907 N  N   . THR   A 1 527 ? -30.511 -49.374 -14.527 0.48 42.76  ? 790  THR   A N   1 
ATOM   3908 C  CA  . THR   A 1 527 ? -30.609 -47.952 -14.106 0.48 48.32  ? 790  THR   A CA  1 
ATOM   3909 C  C   . THR   A 1 527 ? -29.232 -47.306 -13.948 0.48 48.67  ? 790  THR   A C   1 
ATOM   3910 O  O   . THR   A 1 527 ? -28.240 -48.051 -13.889 0.48 49.14  ? 790  THR   A O   1 
ATOM   3911 C  CB  . THR   A 1 527 ? -31.322 -47.825 -12.757 0.48 52.18  ? 790  THR   A CB  1 
ATOM   3912 O  OG1 . THR   A 1 527 ? -30.570 -48.561 -11.792 0.48 56.87  ? 790  THR   A OG1 1 
ATOM   3913 C  CG2 . THR   A 1 527 ? -32.744 -48.332 -12.793 0.48 54.70  ? 790  THR   A CG2 1 
ATOM   3914 N  N   . SER   A 1 528 ? -29.194 -45.973 -13.853 0.48 52.22  ? 791  SER   A N   1 
ATOM   3915 C  CA  . SER   A 1 528 ? -27.925 -45.210 -13.708 0.48 52.79  ? 791  SER   A CA  1 
ATOM   3916 C  C   . SER   A 1 528 ? -26.856 -45.749 -14.661 0.48 51.39  ? 791  SER   A C   1 
ATOM   3917 O  O   . SER   A 1 528 ? -25.847 -45.044 -14.823 0.48 52.62  ? 791  SER   A O   1 
ATOM   3918 C  CB  . SER   A 1 528 ? -27.447 -45.207 -12.285 0.48 53.44  ? 791  SER   A CB  1 
ATOM   3919 O  OG  . SER   A 1 528 ? -28.259 -44.359 -11.488 0.48 54.81  ? 791  SER   A OG  1 
ATOM   3920 N  N   . ILE   A 1 534 ? -19.297 -38.169 -22.490 0.48 97.78  ? 797  ILE   A N   1 
ATOM   3921 C  CA  . ILE   A 1 534 ? -19.992 -37.296 -23.485 0.48 97.93  ? 797  ILE   A CA  1 
ATOM   3922 C  C   . ILE   A 1 534 ? -19.681 -37.814 -24.897 0.48 95.63  ? 797  ILE   A C   1 
ATOM   3923 O  O   . ILE   A 1 534 ? -20.453 -37.508 -25.825 0.48 93.01  ? 797  ILE   A O   1 
ATOM   3924 C  CB  . ILE   A 1 534 ? -19.588 -35.817 -23.298 0.48 96.66  ? 797  ILE   A CB  1 
ATOM   3925 C  CG1 . ILE   A 1 534 ? -19.608 -35.395 -21.825 0.48 96.79  ? 797  ILE   A CG1 1 
ATOM   3926 C  CG2 . ILE   A 1 534 ? -20.460 -34.909 -24.150 0.48 95.52  ? 797  ILE   A CG2 1 
ATOM   3927 C  CD1 . ILE   A 1 534 ? -20.978 -35.430 -21.185 0.48 95.71  ? 797  ILE   A CD1 1 
ATOM   3928 N  N   . HIS   A 1 535 ? -18.594 -38.579 -25.048 0.48 96.66  ? 798  HIS   A N   1 
ATOM   3929 C  CA  . HIS   A 1 535 ? -18.232 -39.300 -26.298 0.48 96.16  ? 798  HIS   A CA  1 
ATOM   3930 C  C   . HIS   A 1 535 ? -19.097 -40.564 -26.419 0.48 97.71  ? 798  HIS   A C   1 
ATOM   3931 O  O   . HIS   A 1 535 ? -18.840 -41.362 -27.344 0.48 96.55  ? 798  HIS   A O   1 
ATOM   3932 C  CB  . HIS   A 1 535 ? -16.726 -39.616 -26.329 0.48 92.17  ? 798  HIS   A CB  1 
ATOM   3933 C  CG  . HIS   A 1 535 ? -16.281 -40.616 -25.311 0.48 93.15  ? 798  HIS   A CG  1 
ATOM   3934 N  ND1 . HIS   A 1 535 ? -16.609 -41.959 -25.394 0.48 93.25  ? 798  HIS   A ND1 1 
ATOM   3935 C  CD2 . HIS   A 1 535 ? -15.526 -40.484 -24.198 0.48 92.78  ? 798  HIS   A CD2 1 
ATOM   3936 C  CE1 . HIS   A 1 535 ? -16.085 -42.605 -24.370 0.48 90.53  ? 798  HIS   A CE1 1 
ATOM   3937 N  NE2 . HIS   A 1 535 ? -15.414 -41.723 -23.622 0.48 93.34  ? 798  HIS   A NE2 1 
ATOM   3938 N  N   . ALA   A 1 536 ? -19.979 -40.824 -25.452 0.48 96.47  ? 799  ALA   A N   1 
ATOM   3939 C  CA  . ALA   A 1 536 ? -20.607 -42.169 -25.428 0.48 95.16  ? 799  ALA   A CA  1 
ATOM   3940 C  C   . ALA   A 1 536 ? -22.087 -42.270 -25.791 0.48 91.88  ? 799  ALA   A C   1 
ATOM   3941 O  O   . ALA   A 1 536 ? -22.796 -41.246 -25.764 0.48 91.50  ? 799  ALA   A O   1 
ATOM   3942 C  CB  . ALA   A 1 536 ? -20.373 -42.770 -24.058 0.48 95.37  ? 799  ALA   A CB  1 
ATOM   3943 N  N   . THR   A 1 537 ? -22.510 -43.492 -26.121 0.48 86.49  ? 800  THR   A N   1 
ATOM   3944 C  CA  . THR   A 1 537 ? -23.933 -43.786 -26.397 0.48 84.15  ? 800  THR   A CA  1 
ATOM   3945 C  C   . THR   A 1 537 ? -24.229 -45.032 -25.560 0.48 79.32  ? 800  THR   A C   1 
ATOM   3946 O  O   . THR   A 1 537 ? -23.497 -46.021 -25.736 0.48 85.07  ? 800  THR   A O   1 
ATOM   3947 C  CB  . THR   A 1 537 ? -24.153 -43.981 -27.899 0.48 83.87  ? 800  THR   A CB  1 
ATOM   3948 O  OG1 . THR   A 1 537 ? -23.262 -45.007 -28.337 0.48 86.10  ? 800  THR   A OG1 1 
ATOM   3949 C  CG2 . THR   A 1 537 ? -23.904 -42.721 -28.696 0.48 81.58  ? 800  THR   A CG2 1 
ATOM   3950 N  N   . HIS   A 1 538 ? -25.218 -44.986 -24.665 0.50 70.78  ? 801  HIS   A N   1 
ATOM   3951 C  CA  . HIS   A 1 538 ? -25.444 -46.126 -23.732 0.50 62.13  ? 801  HIS   A CA  1 
ATOM   3952 C  C   . HIS   A 1 538 ? -26.430 -47.144 -24.313 0.50 52.01  ? 801  HIS   A C   1 
ATOM   3953 O  O   . HIS   A 1 538 ? -27.580 -47.174 -23.853 0.50 44.42  ? 801  HIS   A O   1 
ATOM   3954 C  CB  . HIS   A 1 538 ? -25.861 -45.576 -22.367 0.50 65.43  ? 801  HIS   A CB  1 
ATOM   3955 C  CG  . HIS   A 1 538 ? -24.739 -44.896 -21.658 0.50 72.07  ? 801  HIS   A CG  1 
ATOM   3956 N  ND1 . HIS   A 1 538 ? -24.511 -45.059 -20.306 0.50 76.66  ? 801  HIS   A ND1 1 
ATOM   3957 C  CD2 . HIS   A 1 538 ? -23.767 -44.077 -22.112 0.50 73.12  ? 801  HIS   A CD2 1 
ATOM   3958 C  CE1 . HIS   A 1 538 ? -23.456 -44.354 -19.954 0.50 76.83  ? 801  HIS   A CE1 1 
ATOM   3959 N  NE2 . HIS   A 1 538 ? -22.981 -43.743 -21.045 0.50 76.43  ? 801  HIS   A NE2 1 
ATOM   3960 N  N   . GLU   A 1 539 ? -25.966 -47.980 -25.244 1.00 45.68  ? 802  GLU   A N   1 
ATOM   3961 C  CA  . GLU   A 1 539 ? -26.845 -48.977 -25.909 1.00 45.26  ? 802  GLU   A CA  1 
ATOM   3962 C  C   . GLU   A 1 539 ? -27.170 -50.145 -24.970 1.00 40.69  ? 802  GLU   A C   1 
ATOM   3963 O  O   . GLU   A 1 539 ? -28.105 -50.888 -25.276 1.00 39.90  ? 802  GLU   A O   1 
ATOM   3964 C  CB  . GLU   A 1 539 ? -26.199 -49.472 -27.199 1.00 50.24  ? 802  GLU   A CB  1 
ATOM   3965 C  CG  . GLU   A 1 539 ? -26.448 -48.575 -28.393 1.00 53.32  ? 802  GLU   A CG  1 
ATOM   3966 C  CD  . GLU   A 1 539 ? -25.357 -47.547 -28.610 1.00 62.14  ? 802  GLU   A CD  1 
ATOM   3967 O  OE1 . GLU   A 1 539 ? -25.418 -46.831 -29.625 1.00 71.57  ? 802  GLU   A OE1 1 
ATOM   3968 O  OE2 . GLU   A 1 539 ? -24.450 -47.474 -27.766 1.00 58.61  ? 802  GLU   A OE2 1 
ATOM   3969 N  N   . TRP   A 1 540 ? -26.434 -50.279 -23.872 1.00 33.09  ? 803  TRP   A N   1 
ATOM   3970 C  CA  . TRP   A 1 540 ? -26.688 -51.356 -22.883 1.00 34.51  ? 803  TRP   A CA  1 
ATOM   3971 C  C   . TRP   A 1 540 ? -27.856 -50.986 -21.958 1.00 35.45  ? 803  TRP   A C   1 
ATOM   3972 O  O   . TRP   A 1 540 ? -28.291 -51.849 -21.209 1.00 32.67  ? 803  TRP   A O   1 
ATOM   3973 C  CB  . TRP   A 1 540 ? -25.407 -51.670 -22.097 1.00 34.05  ? 803  TRP   A CB  1 
ATOM   3974 C  CG  . TRP   A 1 540 ? -24.782 -50.507 -21.394 1.00 29.24  ? 803  TRP   A CG  1 
ATOM   3975 C  CD1 . TRP   A 1 540 ? -25.054 -50.064 -20.135 1.00 29.76  ? 803  TRP   A CD1 1 
ATOM   3976 C  CD2 . TRP   A 1 540 ? -23.748 -49.650 -21.906 1.00 30.00  ? 803  TRP   A CD2 1 
ATOM   3977 N  NE1 . TRP   A 1 540 ? -24.272 -48.984 -19.833 1.00 31.45  ? 803  TRP   A NE1 1 
ATOM   3978 C  CE2 . TRP   A 1 540 ? -23.461 -48.707 -20.899 1.00 30.09  ? 803  TRP   A CE2 1 
ATOM   3979 C  CE3 . TRP   A 1 540 ? -23.045 -49.582 -23.112 1.00 33.09  ? 803  TRP   A CE3 1 
ATOM   3980 C  CZ2 . TRP   A 1 540 ? -22.500 -47.712 -21.066 1.00 33.63  ? 803  TRP   A CZ2 1 
ATOM   3981 C  CZ3 . TRP   A 1 540 ? -22.097 -48.600 -23.276 1.00 34.27  ? 803  TRP   A CZ3 1 
ATOM   3982 C  CH2 . TRP   A 1 540 ? -21.829 -47.679 -22.265 1.00 32.17  ? 803  TRP   A CH2 1 
ATOM   3983 N  N   . MET   A 1 541 ? -28.319 -49.735 -22.009 1.00 35.52  ? 804  MET   A N   1 
ATOM   3984 C  CA  . MET   A 1 541 ? -29.439 -49.283 -21.137 1.00 37.97  ? 804  MET   A CA  1 
ATOM   3985 C  C   . MET   A 1 541 ? -30.765 -49.634 -21.852 1.00 38.97  ? 804  MET   A C   1 
ATOM   3986 O  O   . MET   A 1 541 ? -31.300 -48.779 -22.559 1.00 41.43  ? 804  MET   A O   1 
ATOM   3987 C  CB  . MET   A 1 541 ? -29.380 -47.775 -20.840 1.00 39.89  ? 804  MET   A CB  1 
ATOM   3988 C  CG  . MET   A 1 541 ? -28.154 -47.307 -20.083 1.00 43.49  ? 804  MET   A CG  1 
ATOM   3989 S  SD  . MET   A 1 541 ? -27.850 -48.275 -18.578 1.00 48.16  ? 804  MET   A SD  1 
ATOM   3990 C  CE  . MET   A 1 541 ? -29.174 -47.682 -17.520 1.00 48.62  ? 804  MET   A CE  1 
ATOM   3991 N  N   . THR   A 1 542 ? -31.239 -50.871 -21.714 1.00 37.50  ? 805  THR   A N   1 
ATOM   3992 C  CA  . THR   A 1 542 ? -32.383 -51.444 -22.480 1.00 37.63  ? 805  THR   A CA  1 
ATOM   3993 C  C   . THR   A 1 542 ? -32.751 -52.782 -21.859 1.00 37.75  ? 805  THR   A C   1 
ATOM   3994 O  O   . THR   A 1 542 ? -31.851 -53.382 -21.222 1.00 34.16  ? 805  THR   A O   1 
ATOM   3995 C  CB  . THR   A 1 542 ? -32.045 -51.673 -23.959 1.00 42.94  ? 805  THR   A CB  1 
ATOM   3996 O  OG1 . THR   A 1 542 ? -33.114 -52.362 -24.615 1.00 42.39  ? 805  THR   A OG1 1 
ATOM   3997 C  CG2 . THR   A 1 542 ? -30.786 -52.498 -24.143 1.00 46.63  ? 805  THR   A CG2 1 
ATOM   3998 N  N   . THR   A 1 543 ? -33.988 -53.250 -22.079 1.00 32.80  ? 806  THR   A N   1 
ATOM   3999 C  CA  . THR   A 1 543 ? -34.470 -54.616 -21.707 1.00 37.82  ? 806  THR   A CA  1 
ATOM   4000 C  C   . THR   A 1 543 ? -34.489 -55.524 -22.948 1.00 34.19  ? 806  THR   A C   1 
ATOM   4001 O  O   . THR   A 1 543 ? -34.763 -56.754 -22.808 1.00 33.04  ? 806  THR   A O   1 
ATOM   4002 C  CB  . THR   A 1 543 ? -35.850 -54.546 -21.022 1.00 42.90  ? 806  THR   A CB  1 
ATOM   4003 O  OG1 . THR   A 1 543 ? -36.627 -53.606 -21.758 1.00 39.49  ? 806  THR   A OG1 1 
ATOM   4004 C  CG2 . THR   A 1 543 ? -35.763 -54.082 -19.582 1.00 45.29  ? 806  THR   A CG2 1 
ATOM   4005 N  N   . GLU   A 1 544 ? -34.159 -54.985 -24.113 1.00 32.36  ? 807  GLU   A N   1 
ATOM   4006 C  CA  . GLU   A 1 544 ? -33.993 -55.816 -25.335 1.00 34.56  ? 807  GLU   A CA  1 
ATOM   4007 C  C   . GLU   A 1 544 ? -32.916 -56.875 -25.086 1.00 36.84  ? 807  GLU   A C   1 
ATOM   4008 O  O   . GLU   A 1 544 ? -32.085 -56.703 -24.168 1.00 33.04  ? 807  GLU   A O   1 
ATOM   4009 C  CB  . GLU   A 1 544 ? -33.641 -54.942 -26.521 1.00 39.27  ? 807  GLU   A CB  1 
ATOM   4010 C  CG  . GLU   A 1 544 ? -33.707 -55.686 -27.822 1.00 46.64  ? 807  GLU   A CG  1 
ATOM   4011 C  CD  . GLU   A 1 544 ? -33.685 -54.754 -29.024 1.00 57.21  ? 807  GLU   A CD  1 
ATOM   4012 O  OE1 . GLU   A 1 544 ? -34.214 -55.169 -30.098 1.00 57.85  ? 807  GLU   A OE1 1 
ATOM   4013 O  OE2 . GLU   A 1 544 ? -33.146 -53.603 -28.886 1.00 50.48  ? 807  GLU   A OE2 1 
ATOM   4014 N  N   . ASP   A 1 545 ? -33.004 -57.977 -25.818 1.00 34.70  ? 808  ASP   A N   1 
ATOM   4015 C  CA  . ASP   A 1 545 ? -32.084 -59.131 -25.741 1.00 38.37  ? 808  ASP   A CA  1 
ATOM   4016 C  C   . ASP   A 1 545 ? -30.681 -58.647 -26.171 1.00 35.96  ? 808  ASP   A C   1 
ATOM   4017 O  O   . ASP   A 1 545 ? -30.586 -57.919 -27.185 1.00 32.97  ? 808  ASP   A O   1 
ATOM   4018 C  CB  . ASP   A 1 545 ? -32.621 -60.253 -26.622 1.00 43.38  ? 808  ASP   A CB  1 
ATOM   4019 C  CG  . ASP   A 1 545 ? -31.583 -61.285 -27.008 1.00 58.66  ? 808  ASP   A CG  1 
ATOM   4020 O  OD1 . ASP   A 1 545 ? -31.592 -61.692 -28.186 1.00 73.77  ? 808  ASP   A OD1 1 
ATOM   4021 O  OD2 . ASP   A 1 545 ? -30.777 -61.674 -26.126 1.00 74.06  ? 808  ASP   A OD2 1 
ATOM   4022 N  N   . MET   A 1 546 ? -29.626 -59.042 -25.454 1.00 34.19  ? 809  MET   A N   1 
ATOM   4023 C  CA  . MET   A 1 546 ? -28.274 -58.429 -25.649 1.00 32.52  ? 809  MET   A CA  1 
ATOM   4024 C  C   . MET   A 1 546 ? -27.659 -58.943 -26.951 1.00 29.63  ? 809  MET   A C   1 
ATOM   4025 O  O   . MET   A 1 546 ? -26.968 -58.150 -27.589 1.00 30.48  ? 809  MET   A O   1 
ATOM   4026 C  CB  . MET   A 1 546 ? -27.339 -58.657 -24.454 1.00 34.28  ? 809  MET   A CB  1 
ATOM   4027 C  CG  . MET   A 1 546 ? -27.659 -57.733 -23.268 1.00 35.50  ? 809  MET   A CG  1 
ATOM   4028 S  SD  . MET   A 1 546 ? -27.464 -55.954 -23.652 1.00 41.90  ? 809  MET   A SD  1 
ATOM   4029 C  CE  . MET   A 1 546 ? -29.156 -55.417 -23.601 1.00 48.22  ? 809  MET   A CE  1 
ATOM   4030 N  N   . LEU   A 1 547 ? -27.947 -60.169 -27.384 1.00 28.34  ? 810  LEU   A N   1 
ATOM   4031 C  CA  . LEU   A 1 547 ? -27.469 -60.598 -28.723 1.00 30.57  ? 810  LEU   A CA  1 
ATOM   4032 C  C   . LEU   A 1 547 ? -28.062 -59.692 -29.803 1.00 31.20  ? 810  LEU   A C   1 
ATOM   4033 O  O   . LEU   A 1 547 ? -27.333 -59.408 -30.750 1.00 34.67  ? 810  LEU   A O   1 
ATOM   4034 C  CB  . LEU   A 1 547 ? -27.787 -62.055 -29.029 1.00 30.32  ? 810  LEU   A CB  1 
ATOM   4035 C  CG  . LEU   A 1 547 ? -27.119 -62.588 -30.301 1.00 34.25  ? 810  LEU   A CG  1 
ATOM   4036 C  CD1 . LEU   A 1 547 ? -25.591 -62.488 -30.237 1.00 33.11  ? 810  LEU   A CD1 1 
ATOM   4037 C  CD2 . LEU   A 1 547 ? -27.518 -64.033 -30.517 1.00 36.99  ? 810  LEU   A CD2 1 
ATOM   4038 N  N   . THR   A 1 548 ? -29.326 -59.265 -29.701 1.00 30.46  ? 811  THR   A N   1 
ATOM   4039 C  CA  . THR   A 1 548 ? -29.956 -58.412 -30.745 1.00 31.18  ? 811  THR   A CA  1 
ATOM   4040 C  C   . THR   A 1 548 ? -29.298 -57.019 -30.763 1.00 29.61  ? 811  THR   A C   1 
ATOM   4041 O  O   . THR   A 1 548 ? -29.053 -56.481 -31.825 1.00 28.77  ? 811  THR   A O   1 
ATOM   4042 C  CB  . THR   A 1 548 ? -31.472 -58.283 -30.518 1.00 33.79  ? 811  THR   A CB  1 
ATOM   4043 O  OG1 . THR   A 1 548 ? -32.032 -59.592 -30.600 1.00 33.99  ? 811  THR   A OG1 1 
ATOM   4044 C  CG2 . THR   A 1 548 ? -32.150 -57.367 -31.515 1.00 35.72  ? 811  THR   A CG2 1 
ATOM   4045 N  N   . VAL   A 1 549 ? -29.054 -56.433 -29.602 1.00 28.02  ? 812  VAL   A N   1 
ATOM   4046 C  CA  . VAL   A 1 549 ? -28.300 -55.160 -29.473 1.00 33.83  ? 812  VAL   A CA  1 
ATOM   4047 C  C   . VAL   A 1 549 ? -26.865 -55.353 -29.990 1.00 30.50  ? 812  VAL   A C   1 
ATOM   4048 O  O   . VAL   A 1 549 ? -26.409 -54.477 -30.709 1.00 29.35  ? 812  VAL   A O   1 
ATOM   4049 C  CB  . VAL   A 1 549 ? -28.291 -54.621 -28.038 1.00 35.92  ? 812  VAL   A CB  1 
ATOM   4050 C  CG1 . VAL   A 1 549 ? -27.548 -53.294 -28.020 1.00 34.71  ? 812  VAL   A CG1 1 
ATOM   4051 C  CG2 . VAL   A 1 549 ? -29.715 -54.464 -27.484 1.00 39.21  ? 812  VAL   A CG2 1 
ATOM   4052 N  N   . TRP   A 1 550 ? -26.199 -56.471 -29.686 1.00 29.63  ? 813  TRP   A N   1 
ATOM   4053 C  CA  . TRP   A 1 550 ? -24.817 -56.721 -30.197 1.00 29.42  ? 813  TRP   A CA  1 
ATOM   4054 C  C   . TRP   A 1 550 ? -24.837 -56.631 -31.732 1.00 34.03  ? 813  TRP   A C   1 
ATOM   4055 O  O   . TRP   A 1 550 ? -23.958 -55.914 -32.300 1.00 32.08  ? 813  TRP   A O   1 
ATOM   4056 C  CB  . TRP   A 1 550 ? -24.249 -58.045 -29.692 1.00 26.00  ? 813  TRP   A CB  1 
ATOM   4057 C  CG  . TRP   A 1 550 ? -22.782 -58.192 -29.940 1.00 29.53  ? 813  TRP   A CG  1 
ATOM   4058 C  CD1 . TRP   A 1 550 ? -21.765 -58.012 -29.039 1.00 29.19  ? 813  TRP   A CD1 1 
ATOM   4059 C  CD2 . TRP   A 1 550 ? -22.153 -58.584 -31.165 1.00 31.08  ? 813  TRP   A CD2 1 
ATOM   4060 N  NE1 . TRP   A 1 550 ? -20.548 -58.263 -29.617 1.00 30.23  ? 813  TRP   A NE1 1 
ATOM   4061 C  CE2 . TRP   A 1 550 ? -20.751 -58.535 -30.943 1.00 32.23  ? 813  TRP   A CE2 1 
ATOM   4062 C  CE3 . TRP   A 1 550 ? -22.629 -58.970 -32.419 1.00 31.07  ? 813  TRP   A CE3 1 
ATOM   4063 C  CZ2 . TRP   A 1 550 ? -19.835 -58.872 -31.927 1.00 30.39  ? 813  TRP   A CZ2 1 
ATOM   4064 C  CZ3 . TRP   A 1 550 ? -21.716 -59.255 -33.407 1.00 31.65  ? 813  TRP   A CZ3 1 
ATOM   4065 C  CH2 . TRP   A 1 550 ? -20.349 -59.224 -33.154 1.00 32.20  ? 813  TRP   A CH2 1 
ATOM   4066 N  N   . ASN   A 1 551 ? -25.804 -57.314 -32.374 1.00 34.72  ? 814  ASN   A N   1 
ATOM   4067 C  CA  . ASN   A 1 551 ? -25.966 -57.372 -33.852 1.00 33.97  ? 814  ASN   A CA  1 
ATOM   4068 C  C   . ASN   A 1 551 ? -26.189 -55.960 -34.389 1.00 31.40  ? 814  ASN   A C   1 
ATOM   4069 O  O   . ASN   A 1 551 ? -25.536 -55.594 -35.383 1.00 31.59  ? 814  ASN   A O   1 
ATOM   4070 C  CB  . ASN   A 1 551 ? -27.067 -58.335 -34.321 1.00 35.36  ? 814  ASN   A CB  1 
ATOM   4071 C  CG  . ASN   A 1 551 ? -26.543 -59.741 -34.537 1.00 38.78  ? 814  ASN   A CG  1 
ATOM   4072 O  OD1 . ASN   A 1 551 ? -25.605 -59.952 -35.314 1.00 41.65  ? 814  ASN   A OD1 1 
ATOM   4073 N  ND2 . ASN   A 1 551 ? -27.110 -60.711 -33.835 1.00 40.04  ? 814  ASN   A ND2 1 
ATOM   4074 N  N   . ARG   A 1 552 ? -27.064 -55.185 -33.773 1.00 30.26  ? 815  ARG   A N   1 
ATOM   4075 C  CA  . ARG   A 1 552 ? -27.310 -53.796 -34.245 1.00 33.55  ? 815  ARG   A CA  1 
ATOM   4076 C  C   . ARG   A 1 552 ? -26.008 -52.948 -34.185 1.00 36.90  ? 815  ARG   A C   1 
ATOM   4077 O  O   . ARG   A 1 552 ? -25.681 -52.217 -35.183 1.00 38.00  ? 815  ARG   A O   1 
ATOM   4078 C  CB  . ARG   A 1 552 ? -28.436 -53.198 -33.409 1.00 34.02  ? 815  ARG   A CB  1 
ATOM   4079 C  CG  . ARG   A 1 552 ? -28.939 -51.866 -33.938 1.00 36.95  ? 815  ARG   A CG  1 
ATOM   4080 C  CD  . ARG   A 1 552 ? -29.913 -51.216 -32.976 1.00 41.89  ? 815  ARG   A CD  1 
ATOM   4081 N  NE  . ARG   A 1 552 ? -31.017 -52.151 -32.820 1.00 52.91  ? 815  ARG   A NE  1 
ATOM   4082 C  CZ  . ARG   A 1 552 ? -31.551 -52.575 -31.669 1.00 55.88  ? 815  ARG   A CZ  1 
ATOM   4083 N  NH1 . ARG   A 1 552 ? -31.128 -52.125 -30.494 1.00 52.18  ? 815  ARG   A NH1 1 
ATOM   4084 N  NH2 . ARG   A 1 552 ? -32.549 -53.442 -31.728 1.00 60.65  ? 815  ARG   A NH2 1 
ATOM   4085 N  N   . VAL   A 1 553 ? -25.283 -53.012 -33.061 1.00 33.81  ? 816  VAL   A N   1 
ATOM   4086 C  CA  . VAL   A 1 553 ? -24.143 -52.112 -32.740 1.00 33.37  ? 816  VAL   A CA  1 
ATOM   4087 C  C   . VAL   A 1 553 ? -22.928 -52.536 -33.574 1.00 34.17  ? 816  VAL   A C   1 
ATOM   4088 O  O   . VAL   A 1 553 ? -22.304 -51.642 -34.190 1.00 32.64  ? 816  VAL   A O   1 
ATOM   4089 C  CB  . VAL   A 1 553 ? -23.864 -52.102 -31.229 1.00 36.03  ? 816  VAL   A CB  1 
ATOM   4090 C  CG1 . VAL   A 1 553 ? -22.491 -51.555 -30.900 1.00 38.04  ? 816  VAL   A CG1 1 
ATOM   4091 C  CG2 . VAL   A 1 553 ? -24.930 -51.334 -30.493 1.00 32.10  ? 816  VAL   A CG2 1 
ATOM   4092 N  N   . TRP   A 1 554 ? -22.610 -53.834 -33.629 1.00 29.34  ? 817  TRP   A N   1 
ATOM   4093 C  CA  . TRP   A 1 554 ? -21.309 -54.306 -34.172 1.00 27.29  ? 817  TRP   A CA  1 
ATOM   4094 C  C   . TRP   A 1 554 ? -21.433 -54.668 -35.646 1.00 32.26  ? 817  TRP   A C   1 
ATOM   4095 O  O   . TRP   A 1 554 ? -20.394 -54.693 -36.306 1.00 27.24  ? 817  TRP   A O   1 
ATOM   4096 C  CB  . TRP   A 1 554 ? -20.754 -55.469 -33.349 1.00 28.21  ? 817  TRP   A CB  1 
ATOM   4097 C  CG  . TRP   A 1 554 ? -20.256 -55.017 -32.014 1.00 29.20  ? 817  TRP   A CG  1 
ATOM   4098 C  CD1 . TRP   A 1 554 ? -20.860 -55.182 -30.809 1.00 27.52  ? 817  TRP   A CD1 1 
ATOM   4099 C  CD2 . TRP   A 1 554 ? -19.043 -54.284 -31.773 1.00 26.13  ? 817  TRP   A CD2 1 
ATOM   4100 N  NE1 . TRP   A 1 554 ? -20.090 -54.625 -29.835 1.00 26.70  ? 817  TRP   A NE1 1 
ATOM   4101 C  CE2 . TRP   A 1 554 ? -18.992 -54.026 -30.394 1.00 27.27  ? 817  TRP   A CE2 1 
ATOM   4102 C  CE3 . TRP   A 1 554 ? -18.009 -53.822 -32.588 1.00 25.28  ? 817  TRP   A CE3 1 
ATOM   4103 C  CZ2 . TRP   A 1 554 ? -17.917 -53.362 -29.798 1.00 27.44  ? 817  TRP   A CZ2 1 
ATOM   4104 C  CZ3 . TRP   A 1 554 ? -16.947 -53.140 -32.003 1.00 27.25  ? 817  TRP   A CZ3 1 
ATOM   4105 C  CH2 . TRP   A 1 554 ? -16.890 -52.940 -30.623 1.00 26.26  ? 817  TRP   A CH2 1 
ATOM   4106 N  N   . ILE   A 1 555 ? -22.658 -54.929 -36.145 1.00 32.56  ? 818  ILE   A N   1 
ATOM   4107 C  CA  . ILE   A 1 555 ? -22.860 -55.401 -37.545 1.00 33.17  ? 818  ILE   A CA  1 
ATOM   4108 C  C   . ILE   A 1 555 ? -23.675 -54.351 -38.287 1.00 36.27  ? 818  ILE   A C   1 
ATOM   4109 O  O   . ILE   A 1 555 ? -23.085 -53.602 -39.089 1.00 34.14  ? 818  ILE   A O   1 
ATOM   4110 C  CB  . ILE   A 1 555 ? -23.554 -56.771 -37.625 1.00 34.16  ? 818  ILE   A CB  1 
ATOM   4111 C  CG1 . ILE   A 1 555 ? -22.893 -57.849 -36.761 1.00 32.81  ? 818  ILE   A CG1 1 
ATOM   4112 C  CG2 . ILE   A 1 555 ? -23.631 -57.196 -39.080 1.00 35.16  ? 818  ILE   A CG2 1 
ATOM   4113 C  CD1 . ILE   A 1 555 ? -21.528 -58.173 -37.158 1.00 37.31  ? 818  ILE   A CD1 1 
ATOM   4114 N  N   . GLN   A 1 556 ? -24.970 -54.258 -37.959 1.00 41.24  ? 819  GLN   A N   1 
ATOM   4115 C  CA  . GLN   A 1 556 ? -25.979 -53.511 -38.752 1.00 37.00  ? 819  GLN   A CA  1 
ATOM   4116 C  C   . GLN   A 1 556 ? -25.530 -52.054 -38.866 1.00 34.59  ? 819  GLN   A C   1 
ATOM   4117 O  O   . GLN   A 1 556 ? -25.419 -51.580 -39.979 1.00 36.02  ? 819  GLN   A O   1 
ATOM   4118 C  CB  . GLN   A 1 556 ? -27.343 -53.700 -38.090 1.00 43.04  ? 819  GLN   A CB  1 
ATOM   4119 C  CG  . GLN   A 1 556 ? -28.525 -53.235 -38.931 1.00 52.36  ? 819  GLN   A CG  1 
ATOM   4120 C  CD  . GLN   A 1 556 ? -29.770 -52.995 -38.097 1.00 58.10  ? 819  GLN   A CD  1 
ATOM   4121 O  OE1 . GLN   A 1 556 ? -30.362 -51.915 -38.129 1.00 60.93  ? 819  GLN   A OE1 1 
ATOM   4122 N  NE2 . GLN   A 1 556 ? -30.149 -53.980 -37.291 1.00 54.29  ? 819  GLN   A NE2 1 
ATOM   4123 N  N   . GLU   A 1 557 ? -25.237 -51.377 -37.758 1.00 32.94  ? 820  GLU   A N   1 
ATOM   4124 C  CA  . GLU   A 1 557 ? -25.011 -49.907 -37.748 1.00 35.17  ? 820  GLU   A CA  1 
ATOM   4125 C  C   . GLU   A 1 557 ? -23.517 -49.565 -37.845 1.00 36.75  ? 820  GLU   A C   1 
ATOM   4126 O  O   . GLU   A 1 557 ? -23.182 -48.357 -37.698 1.00 39.89  ? 820  GLU   A O   1 
ATOM   4127 C  CB  . GLU   A 1 557 ? -25.562 -49.292 -36.462 1.00 36.96  ? 820  GLU   A CB  1 
ATOM   4128 C  CG  . GLU   A 1 557 ? -27.054 -49.480 -36.284 1.00 45.17  ? 820  GLU   A CG  1 
ATOM   4129 C  CD  . GLU   A 1 557 ? -27.607 -48.743 -35.061 1.00 57.70  ? 820  GLU   A CD  1 
ATOM   4130 O  OE1 . GLU   A 1 557 ? -26.833 -48.563 -34.049 1.00 66.09  ? 820  GLU   A OE1 1 
ATOM   4131 O  OE2 . GLU   A 1 557 ? -28.817 -48.365 -35.094 1.00 65.65  ? 820  GLU   A OE2 1 
ATOM   4132 N  N   . ASN   A 1 558 ? -22.651 -50.568 -38.046 1.00 35.14  ? 821  ASN   A N   1 
ATOM   4133 C  CA  . ASN   A 1 558 ? -21.167 -50.419 -37.988 1.00 31.03  ? 821  ASN   A CA  1 
ATOM   4134 C  C   . ASN   A 1 558 ? -20.693 -50.060 -39.388 1.00 30.52  ? 821  ASN   A C   1 
ATOM   4135 O  O   . ASN   A 1 558 ? -20.672 -50.898 -40.280 1.00 29.50  ? 821  ASN   A O   1 
ATOM   4136 C  CB  . ASN   A 1 558 ? -20.549 -51.719 -37.466 1.00 31.70  ? 821  ASN   A CB  1 
ATOM   4137 C  CG  . ASN   A 1 558 ? -19.035 -51.749 -37.427 1.00 29.60  ? 821  ASN   A CG  1 
ATOM   4138 O  OD1 . ASN   A 1 558 ? -18.403 -50.797 -37.870 1.00 26.22  ? 821  ASN   A OD1 1 
ATOM   4139 N  ND2 . ASN   A 1 558 ? -18.462 -52.848 -36.923 1.00 25.69  ? 821  ASN   A ND2 1 
ATOM   4140 N  N   . PRO   A 1 559 ? -20.297 -48.807 -39.667 1.00 32.74  ? 822  PRO   A N   1 
ATOM   4141 C  CA  . PRO   A 1 559 ? -19.871 -48.451 -41.017 1.00 33.31  ? 822  PRO   A CA  1 
ATOM   4142 C  C   . PRO   A 1 559 ? -18.576 -49.109 -41.486 1.00 34.61  ? 822  PRO   A C   1 
ATOM   4143 O  O   . PRO   A 1 559 ? -18.285 -49.062 -42.652 1.00 39.55  ? 822  PRO   A O   1 
ATOM   4144 C  CB  . PRO   A 1 559 ? -19.703 -46.934 -40.957 1.00 36.90  ? 822  PRO   A CB  1 
ATOM   4145 C  CG  . PRO   A 1 559 ? -19.503 -46.647 -39.492 1.00 35.81  ? 822  PRO   A CG  1 
ATOM   4146 C  CD  . PRO   A 1 559 ? -20.377 -47.648 -38.777 1.00 34.30  ? 822  PRO   A CD  1 
ATOM   4147 N  N   . TRP   A 1 560 ? -17.810 -49.720 -40.599 1.00 35.74  ? 823  TRP   A N   1 
ATOM   4148 C  CA  . TRP   A 1 560 ? -16.552 -50.395 -41.021 1.00 35.50  ? 823  TRP   A CA  1 
ATOM   4149 C  C   . TRP   A 1 560 ? -16.799 -51.859 -41.404 1.00 35.89  ? 823  TRP   A C   1 
ATOM   4150 O  O   . TRP   A 1 560 ? -15.853 -52.462 -41.819 1.00 35.93  ? 823  TRP   A O   1 
ATOM   4151 C  CB  . TRP   A 1 560 ? -15.518 -50.240 -39.908 1.00 35.49  ? 823  TRP   A CB  1 
ATOM   4152 C  CG  . TRP   A 1 560 ? -15.073 -48.818 -39.778 1.00 32.97  ? 823  TRP   A CG  1 
ATOM   4153 C  CD1 . TRP   A 1 560 ? -14.163 -48.175 -40.565 1.00 31.28  ? 823  TRP   A CD1 1 
ATOM   4154 C  CD2 . TRP   A 1 560 ? -15.567 -47.840 -38.851 1.00 30.68  ? 823  TRP   A CD2 1 
ATOM   4155 N  NE1 . TRP   A 1 560 ? -14.025 -46.878 -40.149 1.00 33.06  ? 823  TRP   A NE1 1 
ATOM   4156 C  CE2 . TRP   A 1 560 ? -14.889 -46.635 -39.112 1.00 30.76  ? 823  TRP   A CE2 1 
ATOM   4157 C  CE3 . TRP   A 1 560 ? -16.468 -47.875 -37.789 1.00 30.00  ? 823  TRP   A CE3 1 
ATOM   4158 C  CZ2 . TRP   A 1 560 ? -15.070 -45.489 -38.336 1.00 29.02  ? 823  TRP   A CZ2 1 
ATOM   4159 C  CZ3 . TRP   A 1 560 ? -16.696 -46.725 -37.072 1.00 28.91  ? 823  TRP   A CZ3 1 
ATOM   4160 C  CH2 . TRP   A 1 560 ? -15.999 -45.552 -37.331 1.00 27.70  ? 823  TRP   A CH2 1 
ATOM   4161 N  N   . MET   A 1 561 ? -18.036 -52.374 -41.325 1.00 38.01  ? 824  MET   A N   1 
ATOM   4162 C  CA  . MET   A 1 561 ? -18.415 -53.797 -41.589 1.00 39.26  ? 824  MET   A CA  1 
ATOM   4163 C  C   . MET   A 1 561 ? -19.249 -53.840 -42.882 1.00 38.24  ? 824  MET   A C   1 
ATOM   4164 O  O   . MET   A 1 561 ? -20.401 -53.380 -42.860 1.00 36.49  ? 824  MET   A O   1 
ATOM   4165 C  CB  . MET   A 1 561 ? -19.249 -54.330 -40.413 1.00 43.62  ? 824  MET   A CB  1 
ATOM   4166 C  CG  . MET   A 1 561 ? -19.464 -55.838 -40.377 1.00 47.95  ? 824  MET   A CG  1 
ATOM   4167 S  SD  . MET   A 1 561 ? -17.944 -56.633 -39.880 1.00 65.70  ? 824  MET   A SD  1 
ATOM   4168 C  CE  . MET   A 1 561 ? -18.146 -56.672 -38.098 1.00 62.65  ? 824  MET   A CE  1 
ATOM   4169 N  N   . GLU   A 1 562 ? -18.687 -54.309 -43.992 1.00 43.20  ? 825  GLU   A N   1 
ATOM   4170 C  CA  . GLU   A 1 562 ? -19.392 -54.346 -45.307 1.00 47.63  ? 825  GLU   A CA  1 
ATOM   4171 C  C   . GLU   A 1 562 ? -20.419 -55.493 -45.305 1.00 43.54  ? 825  GLU   A C   1 
ATOM   4172 O  O   . GLU   A 1 562 ? -21.511 -55.268 -45.792 1.00 47.38  ? 825  GLU   A O   1 
ATOM   4173 C  CB  . GLU   A 1 562 ? -18.398 -54.474 -46.468 1.00 53.14  ? 825  GLU   A CB  1 
ATOM   4174 C  CG  . GLU   A 1 562 ? -19.048 -54.494 -47.844 1.00 65.86  ? 825  GLU   A CG  1 
ATOM   4175 C  CD  . GLU   A 1 562 ? -18.114 -54.373 -49.047 1.00 80.29  ? 825  GLU   A CD  1 
ATOM   4176 O  OE1 . GLU   A 1 562 ? -18.629 -54.318 -50.191 1.00 93.47  ? 825  GLU   A OE1 1 
ATOM   4177 O  OE2 . GLU   A 1 562 ? -16.876 -54.308 -48.856 1.00 96.64  ? 825  GLU   A OE2 1 
ATOM   4178 N  N   . ASP   A 1 563 ? -20.090 -56.672 -44.774 1.00 41.75  ? 826  ASP   A N   1 
ATOM   4179 C  CA  . ASP   A 1 563 ? -20.998 -57.850 -44.768 1.00 39.11  ? 826  ASP   A CA  1 
ATOM   4180 C  C   . ASP   A 1 563 ? -21.966 -57.751 -43.585 1.00 36.74  ? 826  ASP   A C   1 
ATOM   4181 O  O   . ASP   A 1 563 ? -21.497 -57.693 -42.453 1.00 37.26  ? 826  ASP   A O   1 
ATOM   4182 C  CB  . ASP   A 1 563 ? -20.167 -59.128 -44.749 1.00 37.43  ? 826  ASP   A CB  1 
ATOM   4183 C  CG  . ASP   A 1 563 ? -20.986 -60.373 -44.451 1.00 39.95  ? 826  ASP   A CG  1 
ATOM   4184 O  OD1 . ASP   A 1 563 ? -22.232 -60.278 -44.357 1.00 38.69  ? 826  ASP   A OD1 1 
ATOM   4185 O  OD2 . ASP   A 1 563 ? -20.370 -61.397 -44.217 1.00 38.31  ? 826  ASP   A OD2 1 
ATOM   4186 N  N   . LYS   A 1 564 ? -23.279 -57.734 -43.818 1.00 38.24  ? 827  LYS   A N   1 
ATOM   4187 C  CA  . LYS   A 1 564 ? -24.271 -57.388 -42.759 1.00 34.42  ? 827  LYS   A CA  1 
ATOM   4188 C  C   . LYS   A 1 564 ? -24.928 -58.669 -42.240 1.00 34.32  ? 827  LYS   A C   1 
ATOM   4189 O  O   . LYS   A 1 564 ? -26.012 -58.564 -41.632 1.00 34.03  ? 827  LYS   A O   1 
ATOM   4190 C  CB  . LYS   A 1 564 ? -25.330 -56.384 -43.236 1.00 37.82  ? 827  LYS   A CB  1 
ATOM   4191 C  CG  . LYS   A 1 564 ? -24.776 -55.031 -43.668 1.00 38.16  ? 827  LYS   A CG  1 
ATOM   4192 C  CD  . LYS   A 1 564 ? -23.851 -54.407 -42.660 1.00 36.72  ? 827  LYS   A CD  1 
ATOM   4193 C  CE  . LYS   A 1 564 ? -23.793 -52.906 -42.773 1.00 38.49  ? 827  LYS   A CE  1 
ATOM   4194 N  NZ  . LYS   A 1 564 ? -22.850 -52.311 -41.794 1.00 40.66  ? 827  LYS   A NZ  1 
ATOM   4195 N  N   . THR   A 1 565 ? -24.306 -59.827 -42.455 1.00 34.20  ? 828  THR   A N   1 
ATOM   4196 C  CA  . THR   A 1 565 ? -24.886 -61.133 -42.026 1.00 36.97  ? 828  THR   A CA  1 
ATOM   4197 C  C   . THR   A 1 565 ? -24.973 -61.146 -40.509 1.00 37.89  ? 828  THR   A C   1 
ATOM   4198 O  O   . THR   A 1 565 ? -23.935 -61.062 -39.844 1.00 37.91  ? 828  THR   A O   1 
ATOM   4199 C  CB  . THR   A 1 565 ? -24.040 -62.345 -42.434 1.00 40.59  ? 828  THR   A CB  1 
ATOM   4200 O  OG1 . THR   A 1 565 ? -23.896 -62.364 -43.850 1.00 49.28  ? 828  THR   A OG1 1 
ATOM   4201 C  CG2 . THR   A 1 565 ? -24.637 -63.655 -41.979 1.00 43.68  ? 828  THR   A CG2 1 
ATOM   4202 N  N   . PRO   A 1 566 ? -26.179 -61.319 -39.919 1.00 41.49  ? 829  PRO   A N   1 
ATOM   4203 C  CA  . PRO   A 1 566 ? -26.334 -61.255 -38.470 1.00 42.47  ? 829  PRO   A CA  1 
ATOM   4204 C  C   . PRO   A 1 566 ? -25.612 -62.447 -37.844 1.00 42.71  ? 829  PRO   A C   1 
ATOM   4205 O  O   . PRO   A 1 566 ? -25.461 -63.467 -38.485 1.00 43.02  ? 829  PRO   A O   1 
ATOM   4206 C  CB  . PRO   A 1 566 ? -27.851 -61.316 -38.216 1.00 41.11  ? 829  PRO   A CB  1 
ATOM   4207 C  CG  . PRO   A 1 566 ? -28.490 -61.138 -39.572 1.00 39.57  ? 829  PRO   A CG  1 
ATOM   4208 C  CD  . PRO   A 1 566 ? -27.458 -61.622 -40.575 1.00 40.18  ? 829  PRO   A CD  1 
ATOM   4209 N  N   . VAL   A 1 567 ? -25.148 -62.265 -36.617 1.00 46.97  ? 830  VAL   A N   1 
ATOM   4210 C  CA  . VAL   A 1 567 ? -24.606 -63.369 -35.778 1.00 43.87  ? 830  VAL   A CA  1 
ATOM   4211 C  C   . VAL   A 1 567 ? -25.807 -64.041 -35.082 1.00 44.79  ? 830  VAL   A C   1 
ATOM   4212 O  O   . VAL   A 1 567 ? -26.686 -63.326 -34.543 1.00 40.08  ? 830  VAL   A O   1 
ATOM   4213 C  CB  . VAL   A 1 567 ? -23.540 -62.805 -34.822 1.00 44.80  ? 830  VAL   A CB  1 
ATOM   4214 C  CG1 . VAL   A 1 567 ? -23.467 -63.578 -33.534 1.00 45.26  ? 830  VAL   A CG1 1 
ATOM   4215 C  CG2 . VAL   A 1 567 ? -22.172 -62.733 -35.485 1.00 42.64  ? 830  VAL   A CG2 1 
ATOM   4216 N  N   . GLU   A 1 568 ? -25.829 -65.375 -35.101 1.00 44.27  ? 831  GLU   A N   1 
ATOM   4217 C  CA  . GLU   A 1 568 ? -26.978 -66.230 -34.698 1.00 49.63  ? 831  GLU   A CA  1 
ATOM   4218 C  C   . GLU   A 1 568 ? -26.840 -66.646 -33.235 1.00 47.76  ? 831  GLU   A C   1 
ATOM   4219 O  O   . GLU   A 1 568 ? -27.872 -66.936 -32.632 1.00 47.89  ? 831  GLU   A O   1 
ATOM   4220 C  CB  . GLU   A 1 568 ? -27.037 -67.479 -35.592 1.00 52.65  ? 831  GLU   A CB  1 
ATOM   4221 C  CG  . GLU   A 1 568 ? -27.453 -67.181 -37.033 1.00 53.67  ? 831  GLU   A CG  1 
ATOM   4222 C  CD  . GLU   A 1 568 ? -28.769 -66.425 -37.126 1.00 56.19  ? 831  GLU   A CD  1 
ATOM   4223 O  OE1 . GLU   A 1 568 ? -29.637 -66.672 -36.273 1.00 54.94  ? 831  GLU   A OE1 1 
ATOM   4224 O  OE2 . GLU   A 1 568 ? -28.913 -65.570 -38.019 1.00 55.68  ? 831  GLU   A OE2 1 
ATOM   4225 N  N   . SER   A 1 569 ? -25.621 -66.715 -32.686 1.00 38.79  ? 832  SER   A N   1 
ATOM   4226 C  CA  . SER   A 1 569 ? -25.411 -67.067 -31.260 1.00 36.04  ? 832  SER   A CA  1 
ATOM   4227 C  C   . SER   A 1 569 ? -24.150 -66.414 -30.682 1.00 38.04  ? 832  SER   A C   1 
ATOM   4228 O  O   . SER   A 1 569 ? -23.246 -65.968 -31.447 1.00 34.96  ? 832  SER   A O   1 
ATOM   4229 C  CB  . SER   A 1 569 ? -25.323 -68.545 -31.099 1.00 34.36  ? 832  SER   A CB  1 
ATOM   4230 O  OG  . SER   A 1 569 ? -24.078 -68.978 -31.548 1.00 36.83  ? 832  SER   A OG  1 
ATOM   4231 N  N   . TRP   A 1 570 ? -24.065 -66.397 -29.363 1.00 34.89  ? 833  TRP   A N   1 
ATOM   4232 C  CA  . TRP   A 1 570 ? -22.912 -65.775 -28.670 1.00 38.03  ? 833  TRP   A CA  1 
ATOM   4233 C  C   . TRP   A 1 570 ? -21.623 -66.544 -29.012 1.00 36.89  ? 833  TRP   A C   1 
ATOM   4234 O  O   . TRP   A 1 570 ? -20.583 -65.924 -29.116 1.00 33.71  ? 833  TRP   A O   1 
ATOM   4235 C  CB  . TRP   A 1 570 ? -23.208 -65.687 -27.178 1.00 31.52  ? 833  TRP   A CB  1 
ATOM   4236 C  CG  . TRP   A 1 570 ? -24.046 -64.510 -26.812 1.00 34.19  ? 833  TRP   A CG  1 
ATOM   4237 C  CD1 . TRP   A 1 570 ? -25.376 -64.511 -26.493 1.00 31.13  ? 833  TRP   A CD1 1 
ATOM   4238 C  CD2 . TRP   A 1 570 ? -23.587 -63.149 -26.650 1.00 31.65  ? 833  TRP   A CD2 1 
ATOM   4239 N  NE1 . TRP   A 1 570 ? -25.779 -63.242 -26.183 1.00 33.43  ? 833  TRP   A NE1 1 
ATOM   4240 C  CE2 . TRP   A 1 570 ? -24.703 -62.389 -26.255 1.00 32.49  ? 833  TRP   A CE2 1 
ATOM   4241 C  CE3 . TRP   A 1 570 ? -22.358 -62.500 -26.808 1.00 34.20  ? 833  TRP   A CE3 1 
ATOM   4242 C  CZ2 . TRP   A 1 570 ? -24.609 -61.021 -25.991 1.00 32.17  ? 833  TRP   A CZ2 1 
ATOM   4243 C  CZ3 . TRP   A 1 570 ? -22.269 -61.149 -26.558 1.00 33.47  ? 833  TRP   A CZ3 1 
ATOM   4244 C  CH2 . TRP   A 1 570 ? -23.386 -60.416 -26.159 1.00 33.90  ? 833  TRP   A CH2 1 
ATOM   4245 N  N   . GLU   A 1 571 ? -21.694 -67.826 -29.329 1.00 37.39  ? 834  GLU   A N   1 
ATOM   4246 C  CA  . GLU   A 1 571 ? -20.473 -68.610 -29.631 1.00 42.60  ? 834  GLU   A CA  1 
ATOM   4247 C  C   . GLU   A 1 571 ? -19.808 -68.160 -30.941 1.00 37.61  ? 834  GLU   A C   1 
ATOM   4248 O  O   . GLU   A 1 571 ? -18.630 -68.436 -31.098 1.00 41.73  ? 834  GLU   A O   1 
ATOM   4249 C  CB  . GLU   A 1 571 ? -20.834 -70.095 -29.645 1.00 51.63  ? 834  GLU   A CB  1 
ATOM   4250 C  CG  . GLU   A 1 571 ? -21.126 -70.616 -28.248 1.00 64.89  ? 834  GLU   A CG  1 
ATOM   4251 C  CD  . GLU   A 1 571 ? -21.385 -72.111 -28.137 1.00 80.69  ? 834  GLU   A CD  1 
ATOM   4252 O  OE1 . GLU   A 1 571 ? -20.817 -72.884 -28.961 1.00 93.62  ? 834  GLU   A OE1 1 
ATOM   4253 O  OE2 . GLU   A 1 571 ? -22.173 -72.501 -27.233 1.00 95.44  ? 834  GLU   A OE2 1 
ATOM   4254 N  N   . GLU   A 1 572 ? -20.529 -67.547 -31.873 1.00 37.62  ? 835  GLU   A N   1 
ATOM   4255 C  CA  . GLU   A 1 572 ? -19.926 -66.926 -33.089 1.00 41.61  ? 835  GLU   A CA  1 
ATOM   4256 C  C   . GLU   A 1 572 ? -19.019 -65.738 -32.692 1.00 38.42  ? 835  GLU   A C   1 
ATOM   4257 O  O   . GLU   A 1 572 ? -18.300 -65.198 -33.580 1.00 34.07  ? 835  GLU   A O   1 
ATOM   4258 C  CB  . GLU   A 1 572 ? -20.998 -66.376 -34.036 1.00 39.22  ? 835  GLU   A CB  1 
ATOM   4259 C  CG  . GLU   A 1 572 ? -21.341 -67.254 -35.222 1.00 46.27  ? 835  GLU   A CG  1 
ATOM   4260 C  CD  . GLU   A 1 572 ? -22.509 -66.704 -36.043 1.00 49.03  ? 835  GLU   A CD  1 
ATOM   4261 O  OE1 . GLU   A 1 572 ? -22.261 -66.066 -37.087 1.00 58.81  ? 835  GLU   A OE1 1 
ATOM   4262 O  OE2 . GLU   A 1 572 ? -23.670 -66.897 -35.638 1.00 49.17  ? 835  GLU   A OE2 1 
ATOM   4263 N  N   . ILE   A 1 573 ? -19.167 -65.237 -31.463 1.00 33.24  ? 836  ILE   A N   1 
ATOM   4264 C  CA  . ILE   A 1 573 ? -18.566 -63.936 -31.056 1.00 32.40  ? 836  ILE   A CA  1 
ATOM   4265 C  C   . ILE   A 1 573 ? -17.261 -64.272 -30.350 1.00 29.74  ? 836  ILE   A C   1 
ATOM   4266 O  O   . ILE   A 1 573 ? -17.254 -64.935 -29.302 1.00 26.96  ? 836  ILE   A O   1 
ATOM   4267 C  CB  . ILE   A 1 573 ? -19.520 -63.096 -30.194 1.00 32.11  ? 836  ILE   A CB  1 
ATOM   4268 C  CG1 . ILE   A 1 573 ? -20.737 -62.627 -30.989 1.00 31.87  ? 836  ILE   A CG1 1 
ATOM   4269 C  CG2 . ILE   A 1 573 ? -18.770 -61.921 -29.583 1.00 38.20  ? 836  ILE   A CG2 1 
ATOM   4270 C  CD1 . ILE   A 1 573 ? -21.848 -62.056 -30.145 1.00 30.72  ? 836  ILE   A CD1 1 
ATOM   4271 N  N   . PRO   A 1 574 ? -16.125 -63.786 -30.886 1.00 28.74  ? 837  PRO   A N   1 
ATOM   4272 C  CA  . PRO   A 1 574 ? -14.819 -64.214 -30.410 1.00 29.44  ? 837  PRO   A CA  1 
ATOM   4273 C  C   . PRO   A 1 574 ? -14.315 -63.545 -29.116 1.00 29.05  ? 837  PRO   A C   1 
ATOM   4274 O  O   . PRO   A 1 574 ? -14.816 -62.546 -28.652 1.00 28.93  ? 837  PRO   A O   1 
ATOM   4275 C  CB  . PRO   A 1 574 ? -13.908 -63.839 -31.578 1.00 30.22  ? 837  PRO   A CB  1 
ATOM   4276 C  CG  . PRO   A 1 574 ? -14.543 -62.584 -32.120 1.00 33.05  ? 837  PRO   A CG  1 
ATOM   4277 C  CD  . PRO   A 1 574 ? -16.040 -62.730 -31.900 1.00 32.64  ? 837  PRO   A CD  1 
ATOM   4278 N  N   . TYR   A 1 575 ? -13.274 -64.139 -28.558 1.00 30.33  ? 838  TYR   A N   1 
ATOM   4279 C  CA  . TYR   A 1 575 ? -12.495 -63.604 -27.424 1.00 29.64  ? 838  TYR   A CA  1 
ATOM   4280 C  C   . TYR   A 1 575 ? -11.111 -63.177 -27.931 1.00 27.88  ? 838  TYR   A C   1 
ATOM   4281 O  O   . TYR   A 1 575 ? -10.694 -63.616 -28.998 1.00 26.19  ? 838  TYR   A O   1 
ATOM   4282 C  CB  . TYR   A 1 575 ? -12.299 -64.737 -26.426 1.00 30.29  ? 838  TYR   A CB  1 
ATOM   4283 C  CG  . TYR   A 1 575 ? -13.522 -65.255 -25.719 1.00 31.26  ? 838  TYR   A CG  1 
ATOM   4284 C  CD1 . TYR   A 1 575 ? -14.129 -64.517 -24.728 1.00 28.16  ? 838  TYR   A CD1 1 
ATOM   4285 C  CD2 . TYR   A 1 575 ? -13.994 -66.537 -25.955 1.00 36.46  ? 838  TYR   A CD2 1 
ATOM   4286 C  CE1 . TYR   A 1 575 ? -15.212 -65.005 -24.017 1.00 31.92  ? 838  TYR   A CE1 1 
ATOM   4287 C  CE2 . TYR   A 1 575 ? -15.082 -67.046 -25.257 1.00 37.48  ? 838  TYR   A CE2 1 
ATOM   4288 C  CZ  . TYR   A 1 575 ? -15.702 -66.272 -24.293 1.00 34.55  ? 838  TYR   A CZ  1 
ATOM   4289 O  OH  . TYR   A 1 575 ? -16.785 -66.748 -23.626 1.00 39.31  ? 838  TYR   A OH  1 
ATOM   4290 N  N   . LEU   A 1 576 ? -10.409 -62.341 -27.158 0.46 27.61  ? 839  LEU   A N   1 
ATOM   4291 C  CA  . LEU   A 1 576 ? -8.955  -62.072 -27.329 0.46 26.96  ? 839  LEU   A CA  1 
ATOM   4292 C  C   . LEU   A 1 576 ? -8.189  -63.389 -27.172 0.46 26.47  ? 839  LEU   A C   1 
ATOM   4293 O  O   . LEU   A 1 576 ? -8.771  -64.355 -26.661 0.46 27.27  ? 839  LEU   A O   1 
ATOM   4294 C  CB  . LEU   A 1 576 ? -8.474  -61.081 -26.265 0.46 27.29  ? 839  LEU   A CB  1 
ATOM   4295 C  CG  . LEU   A 1 576 ? -9.176  -59.726 -26.225 0.46 26.49  ? 839  LEU   A CG  1 
ATOM   4296 C  CD1 . LEU   A 1 576 ? -8.581  -58.867 -25.128 0.46 26.22  ? 839  LEU   A CD1 1 
ATOM   4297 C  CD2 . LEU   A 1 576 ? -9.095  -59.023 -27.572 0.46 26.78  ? 839  LEU   A CD2 1 
ATOM   4298 N  N   . GLY   A 1 577 ? -6.906  -63.410 -27.538 0.46 27.52  ? 840  GLY   A N   1 
ATOM   4299 C  CA  . GLY   A 1 577 ? -6.005  -64.538 -27.229 0.46 26.05  ? 840  GLY   A CA  1 
ATOM   4300 C  C   . GLY   A 1 577 ? -5.971  -64.816 -25.727 0.46 25.27  ? 840  GLY   A C   1 
ATOM   4301 O  O   . GLY   A 1 577 ? -6.125  -63.852 -24.922 0.46 24.22  ? 840  GLY   A O   1 
ATOM   4302 N  N   . LYS   A 1 578 ? -5.818  -66.099 -25.358 0.46 25.42  ? 841  LYS   A N   1 
ATOM   4303 C  CA  . LYS   A 1 578 ? -5.706  -66.546 -23.943 0.46 26.15  ? 841  LYS   A CA  1 
ATOM   4304 C  C   . LYS   A 1 578 ? -4.605  -65.756 -23.228 0.46 25.08  ? 841  LYS   A C   1 
ATOM   4305 O  O   . LYS   A 1 578 ? -4.827  -65.351 -22.075 0.46 25.20  ? 841  LYS   A O   1 
ATOM   4306 C  CB  . LYS   A 1 578 ? -5.409  -68.046 -23.875 0.46 26.97  ? 841  LYS   A CB  1 
ATOM   4307 C  CG  . LYS   A 1 578 ? -6.584  -68.963 -24.193 0.46 27.17  ? 841  LYS   A CG  1 
ATOM   4308 C  CD  . LYS   A 1 578 ? -6.255  -70.448 -24.080 0.46 27.52  ? 841  LYS   A CD  1 
ATOM   4309 C  CE  . LYS   A 1 578 ? -5.275  -70.943 -25.125 0.46 26.94  ? 841  LYS   A CE  1 
ATOM   4310 N  NZ  . LYS   A 1 578 ? -5.801  -70.764 -26.498 0.46 26.50  ? 841  LYS   A NZ  1 
ATOM   4311 N  N   . ARG   A 1 579 ? -3.461  -65.540 -23.878 0.46 24.62  ? 842  ARG   A N   1 
ATOM   4312 C  CA  . ARG   A 1 579 ? -2.299  -64.852 -23.251 0.46 25.03  ? 842  ARG   A CA  1 
ATOM   4313 C  C   . ARG   A 1 579 ? -2.597  -63.345 -23.214 0.46 24.41  ? 842  ARG   A C   1 
ATOM   4314 O  O   . ARG   A 1 579 ? -2.348  -62.719 -22.162 0.46 24.94  ? 842  ARG   A O   1 
ATOM   4315 C  CB  . ARG   A 1 579 ? -1.000  -65.207 -23.986 0.46 24.22  ? 842  ARG   A CB  1 
ATOM   4316 C  CG  . ARG   A 1 579 ? 0.264   -64.791 -23.246 0.46 24.93  ? 842  ARG   A CG  1 
ATOM   4317 C  CD  . ARG   A 1 579 ? 1.545   -65.463 -23.726 0.46 25.05  ? 842  ARG   A CD  1 
ATOM   4318 N  NE  . ARG   A 1 579 ? 1.358   -66.891 -23.953 0.46 24.32  ? 842  ARG   A NE  1 
ATOM   4319 C  CZ  . ARG   A 1 579 ? 1.156   -67.801 -23.003 0.46 24.38  ? 842  ARG   A CZ  1 
ATOM   4320 N  NH1 . ARG   A 1 579 ? 0.966   -69.066 -23.339 0.46 23.73  ? 842  ARG   A NH1 1 
ATOM   4321 N  NH2 . ARG   A 1 579 ? 1.146   -67.461 -21.726 0.46 25.49  ? 842  ARG   A NH2 1 
ATOM   4322 N  N   . GLU   A 1 580 ? -3.142  -62.797 -24.305 0.46 24.80  ? 843  GLU   A N   1 
ATOM   4323 C  CA  . GLU   A 1 580 ? -3.554  -61.364 -24.413 0.46 25.49  ? 843  GLU   A CA  1 
ATOM   4324 C  C   . GLU   A 1 580 ? -4.623  -61.033 -23.362 0.46 23.49  ? 843  GLU   A C   1 
ATOM   4325 O  O   . GLU   A 1 580 ? -4.669  -59.882 -22.930 0.46 23.22  ? 843  GLU   A O   1 
ATOM   4326 C  CB  . GLU   A 1 580 ? -4.113  -61.045 -25.801 0.46 26.05  ? 843  GLU   A CB  1 
ATOM   4327 C  CG  . GLU   A 1 580 ? -3.106  -61.203 -26.915 0.46 27.82  ? 843  GLU   A CG  1 
ATOM   4328 C  CD  . GLU   A 1 580 ? -3.688  -61.021 -28.305 0.46 29.28  ? 843  GLU   A CD  1 
ATOM   4329 O  OE1 . GLU   A 1 580 ? -4.727  -61.657 -28.592 0.46 29.98  ? 843  GLU   A OE1 1 
ATOM   4330 O  OE2 . GLU   A 1 580 ? -3.101  -60.241 -29.093 0.46 30.19  ? 843  GLU   A OE2 1 
ATOM   4331 N  N   . ASP   A 1 581 ? -5.439  -62.009 -22.966 0.46 23.82  ? 844  ASP   A N   1 
ATOM   4332 C  CA  . ASP   A 1 581 ? -6.517  -61.846 -21.953 0.46 24.55  ? 844  ASP   A CA  1 
ATOM   4333 C  C   . ASP   A 1 581 ? -5.867  -61.728 -20.570 0.46 25.35  ? 844  ASP   A C   1 
ATOM   4334 O  O   . ASP   A 1 581 ? -6.245  -60.801 -19.818 0.46 25.45  ? 844  ASP   A O   1 
ATOM   4335 C  CB  . ASP   A 1 581 ? -7.518  -62.998 -22.042 0.46 23.62  ? 844  ASP   A CB  1 
ATOM   4336 C  CG  . ASP   A 1 581 ? -8.920  -62.711 -21.525 0.46 24.00  ? 844  ASP   A CG  1 
ATOM   4337 O  OD1 . ASP   A 1 581 ? -9.152  -61.623 -20.947 0.46 22.64  ? 844  ASP   A OD1 1 
ATOM   4338 O  OD2 . ASP   A 1 581 ? -9.779  -63.591 -21.720 0.46 23.28  ? 844  ASP   A OD2 1 
ATOM   4339 N  N   . GLN   A 1 582 ? -4.904  -62.603 -20.264 0.46 25.75  ? 845  GLN   A N   1 
ATOM   4340 C  CA  . GLN   A 1 582 ? -4.101  -62.554 -19.006 0.46 26.36  ? 845  GLN   A CA  1 
ATOM   4341 C  C   . GLN   A 1 582 ? -3.373  -61.206 -18.928 0.46 25.41  ? 845  GLN   A C   1 
ATOM   4342 O  O   . GLN   A 1 582 ? -3.533  -60.493 -17.906 0.46 25.70  ? 845  GLN   A O   1 
ATOM   4343 C  CB  . GLN   A 1 582 ? -3.100  -63.715 -18.923 0.46 26.87  ? 845  GLN   A CB  1 
ATOM   4344 C  CG  . GLN   A 1 582 ? -3.721  -65.051 -18.547 0.46 27.74  ? 845  GLN   A CG  1 
ATOM   4345 C  CD  . GLN   A 1 582 ? -2.683  -66.122 -18.287 0.46 29.38  ? 845  GLN   A CD  1 
ATOM   4346 O  OE1 . GLN   A 1 582 ? -1.557  -66.064 -18.775 0.46 30.61  ? 845  GLN   A OE1 1 
ATOM   4347 N  NE2 . GLN   A 1 582 ? -3.057  -67.123 -17.506 0.46 29.17  ? 845  GLN   A NE2 1 
ATOM   4348 N  N   . TRP   A 1 583 ? -2.616  -60.856 -19.970 0.46 24.69  ? 846  TRP   A N   1 
ATOM   4349 C  CA  . TRP   A 1 583 ? -1.893  -59.559 -20.058 0.46 24.09  ? 846  TRP   A CA  1 
ATOM   4350 C  C   . TRP   A 1 583 ? -2.819  -58.421 -19.608 0.46 24.70  ? 846  TRP   A C   1 
ATOM   4351 O  O   . TRP   A 1 583 ? -2.372  -57.577 -18.800 0.46 24.24  ? 846  TRP   A O   1 
ATOM   4352 C  CB  . TRP   A 1 583 ? -1.339  -59.321 -21.469 0.46 24.19  ? 846  TRP   A CB  1 
ATOM   4353 C  CG  . TRP   A 1 583 ? -0.150  -60.167 -21.826 0.46 24.28  ? 846  TRP   A CG  1 
ATOM   4354 C  CD1 . TRP   A 1 583 ? 0.754   -60.739 -20.977 0.46 24.57  ? 846  TRP   A CD1 1 
ATOM   4355 C  CD2 . TRP   A 1 583 ? 0.277   -60.521 -23.152 0.46 23.58  ? 846  TRP   A CD2 1 
ATOM   4356 N  NE1 . TRP   A 1 583 ? 1.709   -61.426 -21.682 0.46 24.39  ? 846  TRP   A NE1 1 
ATOM   4357 C  CE2 . TRP   A 1 583 ? 1.432   -61.320 -23.020 0.46 24.12  ? 846  TRP   A CE2 1 
ATOM   4358 C  CE3 . TRP   A 1 583 ? -0.212  -60.251 -24.433 0.46 23.32  ? 846  TRP   A CE3 1 
ATOM   4359 C  CZ2 . TRP   A 1 583 ? 2.099   -61.848 -24.125 0.46 24.34  ? 846  TRP   A CZ2 1 
ATOM   4360 C  CZ3 . TRP   A 1 583 ? 0.445   -60.775 -25.524 0.46 23.95  ? 846  TRP   A CZ3 1 
ATOM   4361 C  CH2 . TRP   A 1 583 ? 1.586   -61.562 -25.370 0.46 24.04  ? 846  TRP   A CH2 1 
ATOM   4362 N  N   . CYS   A 1 584 ? -4.072  -58.400 -20.077 0.46 24.41  ? 847  CYS   A N   1 
ATOM   4363 C  CA  . CYS   A 1 584 ? -5.020  -57.291 -19.795 0.46 24.28  ? 847  CYS   A CA  1 
ATOM   4364 C  C   . CYS   A 1 584 ? -5.891  -57.619 -18.572 0.46 25.28  ? 847  CYS   A C   1 
ATOM   4365 O  O   . CYS   A 1 584 ? -6.994  -57.042 -18.452 0.46 27.01  ? 847  CYS   A O   1 
ATOM   4366 C  CB  . CYS   A 1 584 ? -5.807  -56.936 -21.048 0.46 24.44  ? 847  CYS   A CB  1 
ATOM   4367 S  SG  . CYS   A 1 584 ? -4.793  -56.033 -22.247 0.46 22.24  ? 847  CYS   A SG  1 
ATOM   4368 N  N   . GLY   A 1 585 ? -5.402  -58.492 -17.681 0.46 25.97  ? 848  GLY   A N   1 
ATOM   4369 C  CA  . GLY   A 1 585 ? -5.875  -58.606 -16.287 0.46 25.14  ? 848  GLY   A CA  1 
ATOM   4370 C  C   . GLY   A 1 585 ? -6.608  -59.900 -15.975 0.46 24.25  ? 848  GLY   A C   1 
ATOM   4371 O  O   . GLY   A 1 585 ? -6.884  -60.118 -14.791 0.46 26.61  ? 848  GLY   A O   1 
ATOM   4372 N  N   . SER   A 1 586 ? -6.924  -60.734 -16.966 1.00 24.41  ? 849  SER   A N   1 
ATOM   4373 C  CA  . SER   A 1 586 ? -7.758  -61.950 -16.743 1.00 24.34  ? 849  SER   A CA  1 
ATOM   4374 C  C   . SER   A 1 586 ? -7.152  -62.834 -15.640 1.00 26.77  ? 849  SER   A C   1 
ATOM   4375 O  O   . SER   A 1 586 ? -5.908  -62.972 -15.602 1.00 24.73  ? 849  SER   A O   1 
ATOM   4376 C  CB  . SER   A 1 586 ? -7.892  -62.749 -17.991 1.00 25.72  ? 849  SER   A CB  1 
ATOM   4377 O  OG  . SER   A 1 586 ? -8.719  -63.887 -17.776 1.00 23.79  ? 849  SER   A OG  1 
ATOM   4378 N  N   . LEU   A 1 587 ? -8.015  -63.499 -14.887 1.00 25.08  ? 850  LEU   A N   1 
ATOM   4379 C  CA  . LEU   A 1 587 ? -7.671  -64.530 -13.878 1.00 24.93  ? 850  LEU   A CA  1 
ATOM   4380 C  C   . LEU   A 1 587 ? -7.720  -65.948 -14.448 1.00 27.46  ? 850  LEU   A C   1 
ATOM   4381 O  O   . LEU   A 1 587 ? -7.552  -66.869 -13.673 1.00 28.20  ? 850  LEU   A O   1 
ATOM   4382 C  CB  . LEU   A 1 587 ? -8.624  -64.445 -12.674 1.00 26.66  ? 850  LEU   A CB  1 
ATOM   4383 C  CG  . LEU   A 1 587 ? -8.648  -63.125 -11.912 1.00 28.63  ? 850  LEU   A CG  1 
ATOM   4384 C  CD1 . LEU   A 1 587 ? -9.291  -63.283 -10.538 1.00 30.02  ? 850  LEU   A CD1 1 
ATOM   4385 C  CD2 . LEU   A 1 587 ? -7.242  -62.583 -11.740 1.00 30.23  ? 850  LEU   A CD2 1 
ATOM   4386 N  N   . ILE   A 1 588 ? -7.961  -66.119 -15.755 0.46 27.53  ? 851  ILE   A N   1 
ATOM   4387 C  CA  . ILE   A 1 588 ? -7.933  -67.472 -16.390 0.46 27.99  ? 851  ILE   A CA  1 
ATOM   4388 C  C   . ILE   A 1 588 ? -6.597  -68.134 -16.042 0.46 30.15  ? 851  ILE   A C   1 
ATOM   4389 O  O   . ILE   A 1 588 ? -5.552  -67.445 -16.071 0.46 28.22  ? 851  ILE   A O   1 
ATOM   4390 C  CB  . ILE   A 1 588 ? -8.173  -67.445 -17.914 0.46 26.96  ? 851  ILE   A CB  1 
ATOM   4391 C  CG1 . ILE   A 1 588 ? -7.208  -66.501 -18.637 0.46 26.38  ? 851  ILE   A CG1 1 
ATOM   4392 C  CG2 . ILE   A 1 588 ? -9.634  -67.140 -18.220 0.46 26.18  ? 851  ILE   A CG2 1 
ATOM   4393 C  CD1 . ILE   A 1 588 ? -7.403  -66.429 -20.130 0.46 25.57  ? 851  ILE   A CD1 1 
ATOM   4394 N  N   . GLY   A 1 589 ? -6.643  -69.427 -15.714 1.00 32.69  ? 852  GLY   A N   1 
ATOM   4395 C  CA  . GLY   A 1 589 ? -5.440  -70.190 -15.339 1.00 33.30  ? 852  GLY   A CA  1 
ATOM   4396 C  C   . GLY   A 1 589 ? -5.305  -70.276 -13.841 1.00 36.51  ? 852  GLY   A C   1 
ATOM   4397 O  O   . GLY   A 1 589 ? -4.639  -71.171 -13.422 1.00 39.85  ? 852  GLY   A O   1 
ATOM   4398 N  N   . LEU   A 1 590 ? -5.957  -69.404 -13.059 1.00 34.76  ? 853  LEU   A N   1 
ATOM   4399 C  CA  . LEU   A 1 590 ? -5.941  -69.507 -11.583 1.00 31.74  ? 853  LEU   A CA  1 
ATOM   4400 C  C   . LEU   A 1 590 ? -7.009  -70.482 -11.089 1.00 34.42  ? 853  LEU   A C   1 
ATOM   4401 O  O   . LEU   A 1 590 ? -8.088  -70.696 -11.743 1.00 34.65  ? 853  LEU   A O   1 
ATOM   4402 C  CB  . LEU   A 1 590 ? -6.118  -68.152 -10.904 1.00 32.27  ? 853  LEU   A CB  1 
ATOM   4403 C  CG  . LEU   A 1 590 ? -5.076  -67.068 -11.195 1.00 36.79  ? 853  LEU   A CG  1 
ATOM   4404 C  CD1 . LEU   A 1 590 ? -5.368  -65.865 -10.322 1.00 39.45  ? 853  LEU   A CD1 1 
ATOM   4405 C  CD2 . LEU   A 1 590 ? -3.653  -67.546 -10.957 1.00 37.83  ? 853  LEU   A CD2 1 
ATOM   4406 N  N   . THR   A 1 591 ? -6.694  -71.046 -9.936  1.00 36.08  ? 854  THR   A N   1 
ATOM   4407 C  CA  . THR   A 1 591 ? -7.511  -72.031 -9.193  1.00 39.71  ? 854  THR   A CA  1 
ATOM   4408 C  C   . THR   A 1 591 ? -8.770  -71.342 -8.681  1.00 32.05  ? 854  THR   A C   1 
ATOM   4409 O  O   . THR   A 1 591 ? -9.825  -71.874 -8.926  1.00 36.35  ? 854  THR   A O   1 
ATOM   4410 C  CB  . THR   A 1 591 ? -6.647  -72.650 -8.088  1.00 40.16  ? 854  THR   A CB  1 
ATOM   4411 O  OG1 . THR   A 1 591 ? -5.861  -73.522 -8.876  1.00 45.54  ? 854  THR   A OG1 1 
ATOM   4412 C  CG2 . THR   A 1 591 ? -7.389  -73.452 -7.050  1.00 44.60  ? 854  THR   A CG2 1 
ATOM   4413 N  N   . SER   A 1 592 ? -8.645  -70.185 -8.040  1.00 30.98  ? 855  SER   A N   1 
ATOM   4414 C  CA  . SER   A 1 592 ? -9.810  -69.369 -7.589  1.00 29.97  ? 855  SER   A CA  1 
ATOM   4415 C  C   . SER   A 1 592 ? -10.831 -69.163 -8.723  1.00 31.04  ? 855  SER   A C   1 
ATOM   4416 O  O   . SER   A 1 592 ? -12.045 -69.318 -8.482  1.00 36.09  ? 855  SER   A O   1 
ATOM   4417 C  CB  . SER   A 1 592 ? -9.398  -68.080 -6.970  1.00 31.20  ? 855  SER   A CB  1 
ATOM   4418 O  OG  . SER   A 1 592 ? -8.631  -67.273 -7.858  1.00 35.26  ? 855  SER   A OG  1 
ATOM   4419 N  N   . ARG   A 1 593 ? -10.348 -68.827 -9.921  0.46 30.52  ? 856  ARG   A N   1 
ATOM   4420 C  CA  . ARG   A 1 593 ? -11.180 -68.506 -11.108 0.46 31.24  ? 856  ARG   A CA  1 
ATOM   4421 C  C   . ARG   A 1 593 ? -11.855 -69.791 -11.615 0.46 32.07  ? 856  ARG   A C   1 
ATOM   4422 O  O   . ARG   A 1 593 ? -13.048 -69.725 -11.959 0.46 30.74  ? 856  ARG   A O   1 
ATOM   4423 C  CB  . ARG   A 1 593 ? -10.316 -67.841 -12.185 0.46 31.07  ? 856  ARG   A CB  1 
ATOM   4424 C  CG  . ARG   A 1 593 ? -11.095 -67.208 -13.330 0.46 31.83  ? 856  ARG   A CG  1 
ATOM   4425 C  CD  . ARG   A 1 593 ? -11.499 -68.165 -14.438 0.46 31.82  ? 856  ARG   A CD  1 
ATOM   4426 N  NE  . ARG   A 1 593 ? -12.088 -67.411 -15.535 0.46 32.96  ? 856  ARG   A NE  1 
ATOM   4427 C  CZ  . ARG   A 1 593 ? -12.846 -67.916 -16.503 0.46 31.66  ? 856  ARG   A CZ  1 
ATOM   4428 N  NH1 . ARG   A 1 593 ? -13.120 -69.209 -16.541 0.46 30.98  ? 856  ARG   A NH1 1 
ATOM   4429 N  NH2 . ARG   A 1 593 ? -13.330 -67.113 -17.437 0.46 30.85  ? 856  ARG   A NH2 1 
ATOM   4430 N  N   . ALA   A 1 594 ? -11.112 -70.901 -11.677 1.00 29.88  ? 857  ALA   A N   1 
ATOM   4431 C  CA  . ALA   A 1 594 ? -11.635 -72.226 -12.072 1.00 31.89  ? 857  ALA   A CA  1 
ATOM   4432 C  C   . ALA   A 1 594 ? -12.810 -72.650 -11.159 1.00 33.20  ? 857  ALA   A C   1 
ATOM   4433 O  O   . ALA   A 1 594 ? -13.840 -73.113 -11.676 1.00 28.18  ? 857  ALA   A O   1 
ATOM   4434 C  CB  . ALA   A 1 594 ? -10.527 -73.246 -11.984 1.00 35.82  ? 857  ALA   A CB  1 
ATOM   4435 N  N   . THR   A 1 595 ? -12.682 -72.474 -9.850  1.00 28.89  ? 858  THR   A N   1 
ATOM   4436 C  CA  . THR   A 1 595 ? -13.736 -72.855 -8.892  1.00 35.98  ? 858  THR   A CA  1 
ATOM   4437 C  C   . THR   A 1 595 ? -14.956 -71.955 -9.081  1.00 34.24  ? 858  THR   A C   1 
ATOM   4438 O  O   . THR   A 1 595 ? -16.103 -72.426 -9.009  1.00 33.49  ? 858  THR   A O   1 
ATOM   4439 C  CB  . THR   A 1 595 ? -13.235 -72.712 -7.460  1.00 39.00  ? 858  THR   A CB  1 
ATOM   4440 O  OG1 . THR   A 1 595 ? -12.108 -73.569 -7.392  1.00 44.88  ? 858  THR   A OG1 1 
ATOM   4441 C  CG2 . THR   A 1 595 ? -14.277 -73.118 -6.448  1.00 39.39  ? 858  THR   A CG2 1 
ATOM   4442 N  N   . TRP   A 1 596 ? -14.692 -70.679 -9.283  1.00 32.55  ? 859  TRP   A N   1 
ATOM   4443 C  CA  . TRP   A 1 596 ? -15.747 -69.669 -9.510  1.00 28.71  ? 859  TRP   A CA  1 
ATOM   4444 C  C   . TRP   A 1 596 ? -16.586 -70.079 -10.728 1.00 27.76  ? 859  TRP   A C   1 
ATOM   4445 O  O   . TRP   A 1 596 ? -17.839 -70.133 -10.608 1.00 26.83  ? 859  TRP   A O   1 
ATOM   4446 C  CB  . TRP   A 1 596 ? -15.099 -68.287 -9.650  1.00 29.44  ? 859  TRP   A CB  1 
ATOM   4447 C  CG  . TRP   A 1 596 ? -15.989 -67.208 -10.174 1.00 29.75  ? 859  TRP   A CG  1 
ATOM   4448 C  CD1 . TRP   A 1 596 ? -17.039 -66.646 -9.519  1.00 27.04  ? 859  TRP   A CD1 1 
ATOM   4449 C  CD2 . TRP   A 1 596 ? -15.855 -66.495 -11.413 1.00 30.68  ? 859  TRP   A CD2 1 
ATOM   4450 N  NE1 . TRP   A 1 596 ? -17.542 -65.611 -10.250 1.00 30.34  ? 859  TRP   A NE1 1 
ATOM   4451 C  CE2 . TRP   A 1 596 ? -16.869 -65.509 -11.427 1.00 28.65  ? 859  TRP   A CE2 1 
ATOM   4452 C  CE3 . TRP   A 1 596 ? -14.989 -66.585 -12.506 1.00 31.55  ? 859  TRP   A CE3 1 
ATOM   4453 C  CZ2 . TRP   A 1 596 ? -17.060 -64.626 -12.485 1.00 28.38  ? 859  TRP   A CZ2 1 
ATOM   4454 C  CZ3 . TRP   A 1 596 ? -15.142 -65.684 -13.543 1.00 33.40  ? 859  TRP   A CZ3 1 
ATOM   4455 C  CH2 . TRP   A 1 596 ? -16.189 -64.733 -13.539 1.00 32.88  ? 859  TRP   A CH2 1 
ATOM   4456 N  N   . ALA   A 1 597 ? -15.962 -70.276 -11.879 1.00 26.69  ? 860  ALA   A N   1 
ATOM   4457 C  CA  . ALA   A 1 597 ? -16.640 -70.688 -13.143 1.00 31.03  ? 860  ALA   A CA  1 
ATOM   4458 C  C   . ALA   A 1 597 ? -17.406 -72.015 -12.970 1.00 32.44  ? 860  ALA   A C   1 
ATOM   4459 O  O   . ALA   A 1 597 ? -18.617 -72.082 -13.249 1.00 33.46  ? 860  ALA   A O   1 
ATOM   4460 C  CB  . ALA   A 1 597 ? -15.629 -70.784 -14.257 1.00 28.91  ? 860  ALA   A CB  1 
ATOM   4461 N  N   . LYS   A 1 598 ? -16.716 -73.037 -12.480 1.00 37.71  ? 861  LYS   A N   1 
ATOM   4462 C  CA  . LYS   A 1 598 ? -17.278 -74.388 -12.263 1.00 38.31  ? 861  LYS   A CA  1 
ATOM   4463 C  C   . LYS   A 1 598 ? -18.549 -74.262 -11.426 1.00 33.96  ? 861  LYS   A C   1 
ATOM   4464 O  O   . LYS   A 1 598 ? -19.548 -74.832 -11.843 1.00 33.31  ? 861  LYS   A O   1 
ATOM   4465 C  CB  . LYS   A 1 598 ? -16.244 -75.269 -11.562 1.00 49.34  ? 861  LYS   A CB  1 
ATOM   4466 C  CG  . LYS   A 1 598 ? -16.532 -76.765 -11.571 1.00 61.03  ? 861  LYS   A CG  1 
ATOM   4467 C  CD  . LYS   A 1 598 ? -15.284 -77.620 -11.379 1.00 73.39  ? 861  LYS   A CD  1 
ATOM   4468 C  CE  . LYS   A 1 598 ? -15.186 -78.766 -12.373 1.00 83.59  ? 861  LYS   A CE  1 
ATOM   4469 N  NZ  . LYS   A 1 598 ? -16.442 -79.559 -12.464 1.00 83.51  ? 861  LYS   A NZ  1 
ATOM   4470 N  N   . ASN   A 1 599 ? -18.518 -73.505 -10.325 1.00 31.73  ? 862  ASN   A N   1 
ATOM   4471 C  CA  . ASN   A 1 599 ? -19.633 -73.429 -9.332  1.00 34.42  ? 862  ASN   A CA  1 
ATOM   4472 C  C   . ASN   A 1 599 ? -20.519 -72.199 -9.527  1.00 29.92  ? 862  ASN   A C   1 
ATOM   4473 O  O   . ASN   A 1 599 ? -21.191 -71.796 -8.567  1.00 33.07  ? 862  ASN   A O   1 
ATOM   4474 C  CB  . ASN   A 1 599 ? -19.086 -73.418 -7.901  1.00 32.72  ? 862  ASN   A CB  1 
ATOM   4475 C  CG  . ASN   A 1 599 ? -18.337 -74.699 -7.622  1.00 37.01  ? 862  ASN   A CG  1 
ATOM   4476 O  OD1 . ASN   A 1 599 ? -18.889 -75.767 -7.765  1.00 38.14  ? 862  ASN   A OD1 1 
ATOM   4477 N  ND2 . ASN   A 1 599 ? -17.067 -74.604 -7.318  1.00 42.08  ? 862  ASN   A ND2 1 
ATOM   4478 N  N   . ILE   A 1 600 ? -20.532 -71.605 -10.704 1.00 30.36  ? 863  ILE   A N   1 
ATOM   4479 C  CA  . ILE   A 1 600 ? -21.209 -70.282 -10.901 1.00 28.64  ? 863  ILE   A CA  1 
ATOM   4480 C  C   . ILE   A 1 600 ? -22.726 -70.329 -10.567 1.00 29.92  ? 863  ILE   A C   1 
ATOM   4481 O  O   . ILE   A 1 600 ? -23.234 -69.345 -10.030 1.00 25.75  ? 863  ILE   A O   1 
ATOM   4482 C  CB  . ILE   A 1 600 ? -20.938 -69.762 -12.319 1.00 27.42  ? 863  ILE   A CB  1 
ATOM   4483 C  CG1 . ILE   A 1 600 ? -21.284 -68.272 -12.445 1.00 30.73  ? 863  ILE   A CG1 1 
ATOM   4484 C  CG2 . ILE   A 1 600 ? -21.626 -70.619 -13.365 1.00 28.20  ? 863  ILE   A CG2 1 
ATOM   4485 C  CD1 . ILE   A 1 600 ? -20.447 -67.368 -11.557 1.00 28.63  ? 863  ILE   A CD1 1 
ATOM   4486 N  N   A GLN   A 1 601 ? -23.400 -71.451 -10.859 0.25 29.01  ? 864  GLN   A N   1 
ATOM   4487 N  N   B GLN   A 1 601 ? -23.406 -71.447 -10.849 0.25 29.54  ? 864  GLN   A N   1 
ATOM   4488 C  CA  A GLN   A 1 601 ? -24.862 -71.635 -10.620 0.25 30.67  ? 864  GLN   A CA  1 
ATOM   4489 C  CA  B GLN   A 1 601 ? -24.875 -71.587 -10.626 0.25 31.63  ? 864  GLN   A CA  1 
ATOM   4490 C  C   A GLN   A 1 601 ? -25.169 -71.491 -9.123  0.25 30.47  ? 864  GLN   A C   1 
ATOM   4491 C  C   B GLN   A 1 601 ? -25.182 -71.510 -9.121  0.25 30.97  ? 864  GLN   A C   1 
ATOM   4492 O  O   A GLN   A 1 601 ? -26.272 -71.015 -8.787  0.25 29.43  ? 864  GLN   A O   1 
ATOM   4493 O  O   B GLN   A 1 601 ? -26.297 -71.078 -8.774  0.25 29.93  ? 864  GLN   A O   1 
ATOM   4494 C  CB  A GLN   A 1 601 ? -25.364 -72.986 -11.138 0.25 30.48  ? 864  GLN   A CB  1 
ATOM   4495 C  CB  B GLN   A 1 601 ? -25.416 -72.863 -11.277 0.25 32.12  ? 864  GLN   A CB  1 
ATOM   4496 C  CG  A GLN   A 1 601 ? -25.366 -73.102 -12.657 0.25 30.32  ? 864  GLN   A CG  1 
ATOM   4497 C  CG  B GLN   A 1 601 ? -26.932 -73.005 -11.200 0.25 32.14  ? 864  GLN   A CG  1 
ATOM   4498 C  CD  A GLN   A 1 601 ? -26.275 -72.117 -13.352 0.25 29.71  ? 864  GLN   A CD  1 
ATOM   4499 C  CD  B GLN   A 1 601 ? -27.712 -71.813 -11.704 0.25 33.41  ? 864  GLN   A CD  1 
ATOM   4500 O  OE1 A GLN   A 1 601 ? -27.186 -71.548 -12.757 0.25 31.55  ? 864  GLN   A OE1 1 
ATOM   4501 O  OE1 B GLN   A 1 601 ? -27.606 -71.411 -12.861 0.25 34.24  ? 864  GLN   A OE1 1 
ATOM   4502 N  NE2 A GLN   A 1 601 ? -26.043 -71.929 -14.641 0.25 28.75  ? 864  GLN   A NE2 1 
ATOM   4503 N  NE2 B GLN   A 1 601 ? -28.545 -71.260 -10.838 0.25 32.66  ? 864  GLN   A NE2 1 
ATOM   4504 N  N   . THR   A 1 602 ? -24.221 -71.856 -8.263  1.00 30.11  ? 865  THR   A N   1 
ATOM   4505 C  CA  . THR   A 1 602 ? -24.368 -71.729 -6.791  1.00 33.20  ? 865  THR   A CA  1 
ATOM   4506 C  C   . THR   A 1 602 ? -24.294 -70.253 -6.362  1.00 31.79  ? 865  THR   A C   1 
ATOM   4507 O  O   . THR   A 1 602 ? -24.970 -69.867 -5.401  1.00 31.18  ? 865  THR   A O   1 
ATOM   4508 C  CB  . THR   A 1 602 ? -23.298 -72.569 -6.103  1.00 35.97  ? 865  THR   A CB  1 
ATOM   4509 O  OG1 . THR   A 1 602 ? -23.447 -73.911 -6.587  1.00 39.73  ? 865  THR   A OG1 1 
ATOM   4510 C  CG2 . THR   A 1 602 ? -23.413 -72.459 -4.603  1.00 41.84  ? 865  THR   A CG2 1 
ATOM   4511 N  N   . ALA   A 1 603 ? -23.472 -69.441 -7.009  1.00 33.18  ? 866  ALA   A N   1 
ATOM   4512 C  CA  . ALA   A 1 603 ? -23.380 -67.990 -6.719  1.00 29.23  ? 866  ALA   A CA  1 
ATOM   4513 C  C   . ALA   A 1 603 ? -24.644 -67.328 -7.245  1.00 25.85  ? 866  ALA   A C   1 
ATOM   4514 O  O   . ALA   A 1 603 ? -25.205 -66.543 -6.557  1.00 23.31  ? 866  ALA   A O   1 
ATOM   4515 C  CB  . ALA   A 1 603 ? -22.173 -67.392 -7.370  1.00 29.63  ? 866  ALA   A CB  1 
ATOM   4516 N  N   . ILE   A 1 604 ? -25.048 -67.666 -8.462  1.00 26.71  ? 867  ILE   A N   1 
ATOM   4517 C  CA  . ILE   A 1 604 ? -26.299 -67.154 -9.072  1.00 27.38  ? 867  ILE   A CA  1 
ATOM   4518 C  C   . ILE   A 1 604 ? -27.461 -67.434 -8.112  1.00 27.38  ? 867  ILE   A C   1 
ATOM   4519 O  O   . ILE   A 1 604 ? -28.210 -66.518 -7.831  1.00 26.50  ? 867  ILE   A O   1 
ATOM   4520 C  CB  . ILE   A 1 604 ? -26.483 -67.775 -10.460 1.00 27.11  ? 867  ILE   A CB  1 
ATOM   4521 C  CG1 . ILE   A 1 604 ? -25.393 -67.280 -11.420 1.00 27.24  ? 867  ILE   A CG1 1 
ATOM   4522 C  CG2 . ILE   A 1 604 ? -27.873 -67.465 -10.992 1.00 27.49  ? 867  ILE   A CG2 1 
ATOM   4523 C  CD1 . ILE   A 1 604 ? -25.482 -67.883 -12.813 1.00 28.51  ? 867  ILE   A CD1 1 
ATOM   4524 N  N   . ASN   A 1 605 ? -27.545 -68.646 -7.551  1.00 30.08  ? 868  ASN   A N   1 
ATOM   4525 C  CA  . ASN   A 1 605 ? -28.652 -69.068 -6.654  1.00 30.46  ? 868  ASN   A CA  1 
ATOM   4526 C  C   . ASN   A 1 605 ? -28.579 -68.302 -5.323  1.00 30.61  ? 868  ASN   A C   1 
ATOM   4527 O  O   . ASN   A 1 605 ? -29.630 -68.010 -4.769  1.00 31.28  ? 868  ASN   A O   1 
ATOM   4528 C  CB  . ASN   A 1 605 ? -28.662 -70.592 -6.465  1.00 32.98  ? 868  ASN   A CB  1 
ATOM   4529 C  CG  . ASN   A 1 605 ? -29.097 -71.347 -7.707  1.00 41.27  ? 868  ASN   A CG  1 
ATOM   4530 O  OD1 . ASN   A 1 605 ? -29.812 -70.837 -8.585  1.00 47.55  ? 868  ASN   A OD1 1 
ATOM   4531 N  ND2 . ASN   A 1 605 ? -28.648 -72.581 -7.814  1.00 45.63  ? 868  ASN   A ND2 1 
ATOM   4532 N  N   . GLN   A 1 606 ? -27.394 -68.017 -4.791  1.00 29.95  ? 869  GLN   A N   1 
ATOM   4533 C  CA  . GLN   A 1 606 ? -27.258 -67.210 -3.558  1.00 31.91  ? 869  GLN   A CA  1 
ATOM   4534 C  C   . GLN   A 1 606 ? -27.948 -65.860 -3.771  1.00 30.64  ? 869  GLN   A C   1 
ATOM   4535 O  O   . GLN   A 1 606 ? -28.747 -65.430 -2.928  1.00 32.51  ? 869  GLN   A O   1 
ATOM   4536 C  CB  . GLN   A 1 606 ? -25.801 -66.992 -3.138  1.00 33.71  ? 869  GLN   A CB  1 
ATOM   4537 C  CG  . GLN   A 1 606 ? -25.674 -66.180 -1.829  1.00 41.55  ? 869  GLN   A CG  1 
ATOM   4538 C  CD  . GLN   A 1 606 ? -24.258 -65.898 -1.340  1.00 49.26  ? 869  GLN   A CD  1 
ATOM   4539 O  OE1 . GLN   A 1 606 ? -23.299 -65.833 -2.126  1.00 49.05  ? 869  GLN   A OE1 1 
ATOM   4540 N  NE2 . GLN   A 1 606 ? -24.110 -65.736 -0.032  1.00 41.76  ? 869  GLN   A NE2 1 
ATOM   4541 N  N   . VAL   A 1 607 ? -27.621 -65.180 -4.853  1.00 27.41  ? 870  VAL   A N   1 
ATOM   4542 C  CA  . VAL   A 1 607 ? -28.177 -63.828 -5.115  1.00 27.23  ? 870  VAL   A CA  1 
ATOM   4543 C  C   . VAL   A 1 607 ? -29.702 -63.968 -5.387  1.00 26.63  ? 870  VAL   A C   1 
ATOM   4544 O  O   . VAL   A 1 607 ? -30.471 -63.103 -4.917  1.00 25.70  ? 870  VAL   A O   1 
ATOM   4545 C  CB  . VAL   A 1 607 ? -27.428 -63.181 -6.284  1.00 26.77  ? 870  VAL   A CB  1 
ATOM   4546 C  CG1 . VAL   A 1 607 ? -28.124 -61.923 -6.780  1.00 26.16  ? 870  VAL   A CG1 1 
ATOM   4547 C  CG2 . VAL   A 1 607 ? -25.967 -62.936 -5.912  1.00 31.15  ? 870  VAL   A CG2 1 
ATOM   4548 N  N   . ARG   A 1 608 ? -30.133 -64.995 -6.119  1.00 25.02  ? 871  ARG   A N   1 
ATOM   4549 C  CA  . ARG   A 1 608 ? -31.585 -65.181 -6.403  1.00 29.30  ? 871  ARG   A CA  1 
ATOM   4550 C  C   . ARG   A 1 608 ? -32.342 -65.353 -5.080  1.00 31.69  ? 871  ARG   A C   1 
ATOM   4551 O  O   . ARG   A 1 608 ? -33.462 -64.797 -4.944  1.00 35.00  ? 871  ARG   A O   1 
ATOM   4552 C  CB  . ARG   A 1 608 ? -31.801 -66.375 -7.332  1.00 27.29  ? 871  ARG   A CB  1 
ATOM   4553 C  CG  . ARG   A 1 608 ? -31.367 -66.109 -8.768  1.00 27.43  ? 871  ARG   A CG  1 
ATOM   4554 C  CD  . ARG   A 1 608 ? -31.669 -67.340 -9.591  1.00 28.06  ? 871  ARG   A CD  1 
ATOM   4555 N  NE  . ARG   A 1 608 ? -31.567 -67.073 -11.011 1.00 32.47  ? 871  ARG   A NE  1 
ATOM   4556 C  CZ  . ARG   A 1 608 ? -31.458 -68.006 -11.945 1.00 32.64  ? 871  ARG   A CZ  1 
ATOM   4557 N  NH1 . ARG   A 1 608 ? -31.480 -69.280 -11.609 1.00 38.77  ? 871  ARG   A NH1 1 
ATOM   4558 N  NH2 . ARG   A 1 608 ? -31.334 -67.679 -13.213 1.00 32.45  ? 871  ARG   A NH2 1 
ATOM   4559 N  N   . SER   A 1 609 ? -31.773 -66.116 -4.146  1.00 30.36  ? 872  SER   A N   1 
ATOM   4560 C  CA  . SER   A 1 609 ? -32.382 -66.352 -2.817  1.00 29.98  ? 872  SER   A CA  1 
ATOM   4561 C  C   . SER   A 1 609 ? -32.520 -65.048 -2.039  1.00 30.98  ? 872  SER   A C   1 
ATOM   4562 O  O   . SER   A 1 609 ? -33.466 -64.925 -1.259  1.00 31.83  ? 872  SER   A O   1 
ATOM   4563 C  CB  . SER   A 1 609 ? -31.599 -67.362 -2.049  1.00 30.60  ? 872  SER   A CB  1 
ATOM   4564 O  OG  . SER   A 1 609 ? -31.583 -68.567 -2.806  1.00 30.39  ? 872  SER   A OG  1 
ATOM   4565 N  N   . LEU   A 1 610 ? -31.598 -64.116 -2.211  1.00 30.28  ? 873  LEU   A N   1 
ATOM   4566 C  CA  . LEU   A 1 610 ? -31.591 -62.840 -1.445  1.00 30.50  ? 873  LEU   A CA  1 
ATOM   4567 C  C   . LEU   A 1 610 ? -32.692 -61.924 -2.007  1.00 31.97  ? 873  LEU   A C   1 
ATOM   4568 O  O   . LEU   A 1 610 ? -33.442 -61.340 -1.204  1.00 29.19  ? 873  LEU   A O   1 
ATOM   4569 C  CB  . LEU   A 1 610 ? -30.202 -62.210 -1.561  1.00 31.72  ? 873  LEU   A CB  1 
ATOM   4570 C  CG  . LEU   A 1 610 ? -29.119 -62.845 -0.701  1.00 31.73  ? 873  LEU   A CG  1 
ATOM   4571 C  CD1 . LEU   A 1 610 ? -27.767 -62.195 -0.975  1.00 35.80  ? 873  LEU   A CD1 1 
ATOM   4572 C  CD2 . LEU   A 1 610 ? -29.464 -62.752 0.790   1.00 33.93  ? 873  LEU   A CD2 1 
ATOM   4573 N  N   . ILE   A 1 611 ? -32.781 -61.848 -3.339  1.00 29.19  ? 874  ILE   A N   1 
ATOM   4574 C  CA  . ILE   A 1 611 ? -33.748 -61.001 -4.080  1.00 31.39  ? 874  ILE   A CA  1 
ATOM   4575 C  C   . ILE   A 1 611 ? -35.160 -61.600 -3.923  1.00 32.95  ? 874  ILE   A C   1 
ATOM   4576 O  O   . ILE   A 1 611 ? -36.082 -60.836 -3.646  1.00 33.00  ? 874  ILE   A O   1 
ATOM   4577 C  CB  . ILE   A 1 611 ? -33.322 -60.827 -5.548  1.00 31.22  ? 874  ILE   A CB  1 
ATOM   4578 C  CG1 . ILE   A 1 611 ? -32.047 -59.986 -5.662  1.00 30.44  ? 874  ILE   A CG1 1 
ATOM   4579 C  CG2 . ILE   A 1 611 ? -34.476 -60.196 -6.326  1.00 33.97  ? 874  ILE   A CG2 1 
ATOM   4580 C  CD1 . ILE   A 1 611 ? -31.449 -59.961 -7.026  1.00 30.55  ? 874  ILE   A CD1 1 
ATOM   4581 N  N   . GLY   A 1 612 ? -35.302 -62.921 -3.992  1.00 32.72  ? 875  GLY   A N   1 
ATOM   4582 C  CA  . GLY   A 1 612 ? -36.558 -63.624 -3.635  1.00 36.99  ? 875  GLY   A CA  1 
ATOM   4583 C  C   . GLY   A 1 612 ? -37.202 -64.289 -4.844  1.00 35.77  ? 875  GLY   A C   1 
ATOM   4584 O  O   . GLY   A 1 612 ? -36.531 -64.521 -5.850  1.00 33.87  ? 875  GLY   A O   1 
ATOM   4585 N  N   . ASN   A 1 613 ? -38.501 -64.537 -4.784  1.00 41.26  ? 876  ASN   A N   1 
ATOM   4586 C  CA  . ASN   A 1 613 ? -39.200 -65.456 -5.722  1.00 43.12  ? 876  ASN   A CA  1 
ATOM   4587 C  C   . ASN   A 1 613 ? -39.703 -64.646 -6.921  1.00 41.93  ? 876  ASN   A C   1 
ATOM   4588 O  O   . ASN   A 1 613 ? -40.865 -64.205 -6.910  1.00 54.87  ? 876  ASN   A O   1 
ATOM   4589 C  CB  . ASN   A 1 613 ? -40.321 -66.210 -5.005  1.00 48.07  ? 876  ASN   A CB  1 
ATOM   4590 C  CG  . ASN   A 1 613 ? -40.898 -67.329 -5.845  1.00 54.77  ? 876  ASN   A CG  1 
ATOM   4591 O  OD1 . ASN   A 1 613 ? -40.302 -67.732 -6.838  1.00 60.42  ? 876  ASN   A OD1 1 
ATOM   4592 N  ND2 . ASN   A 1 613 ? -42.039 -67.866 -5.435  1.00 57.87  ? 876  ASN   A ND2 1 
ATOM   4593 N  N   . GLU   A 1 614 ? -38.848 -64.485 -7.922  1.00 33.99  ? 877  GLU   A N   1 
ATOM   4594 C  CA  . GLU   A 1 614 ? -39.019 -63.550 -9.054  1.00 32.30  ? 877  GLU   A CA  1 
ATOM   4595 C  C   . GLU   A 1 614 ? -38.887 -64.394 -10.299 1.00 31.18  ? 877  GLU   A C   1 
ATOM   4596 O  O   . GLU   A 1 614 ? -38.645 -65.601 -10.120 1.00 31.25  ? 877  GLU   A O   1 
ATOM   4597 C  CB  . GLU   A 1 614 ? -37.971 -62.448 -9.006  1.00 32.51  ? 877  GLU   A CB  1 
ATOM   4598 C  CG  . GLU   A 1 614 ? -38.151 -61.534 -7.822  1.00 32.60  ? 877  GLU   A CG  1 
ATOM   4599 C  CD  . GLU   A 1 614 ? -39.311 -60.550 -7.886  1.00 32.86  ? 877  GLU   A CD  1 
ATOM   4600 O  OE1 . GLU   A 1 614 ? -39.914 -60.340 -8.990  1.00 30.65  ? 877  GLU   A OE1 1 
ATOM   4601 O  OE2 . GLU   A 1 614 ? -39.570 -59.937 -6.830  1.00 33.28  ? 877  GLU   A OE2 1 
ATOM   4602 N  N   . GLU   A 1 615 ? -39.084 -63.814 -11.482 1.00 34.08  ? 878  GLU   A N   1 
ATOM   4603 C  CA  . GLU   A 1 615 ? -38.882 -64.544 -12.768 1.00 36.19  ? 878  GLU   A CA  1 
ATOM   4604 C  C   . GLU   A 1 615 ? -37.441 -64.273 -13.221 1.00 35.39  ? 878  GLU   A C   1 
ATOM   4605 O  O   . GLU   A 1 615 ? -37.173 -63.104 -13.502 1.00 30.59  ? 878  GLU   A O   1 
ATOM   4606 C  CB  . GLU   A 1 615 ? -39.834 -64.092 -13.878 1.00 41.67  ? 878  GLU   A CB  1 
ATOM   4607 C  CG  . GLU   A 1 615 ? -39.553 -64.814 -15.195 1.00 51.71  ? 878  GLU   A CG  1 
ATOM   4608 C  CD  . GLU   A 1 615 ? -40.374 -64.369 -16.399 1.00 70.67  ? 878  GLU   A CD  1 
ATOM   4609 O  OE1 . GLU   A 1 615 ? -41.385 -63.628 -16.223 1.00 73.46  ? 878  GLU   A OE1 1 
ATOM   4610 O  OE2 . GLU   A 1 615 ? -40.007 -64.768 -17.523 1.00 77.30  ? 878  GLU   A OE2 1 
ATOM   4611 N  N   . TYR   A 1 616 ? -36.631 -65.329 -13.321 1.00 34.93  ? 879  TYR   A N   1 
ATOM   4612 C  CA  . TYR   A 1 616 ? -35.221 -65.381 -13.782 1.00 39.57  ? 879  TYR   A CA  1 
ATOM   4613 C  C   . TYR   A 1 616 ? -35.100 -66.180 -15.082 1.00 42.42  ? 879  TYR   A C   1 
ATOM   4614 O  O   . TYR   A 1 616 ? -35.839 -67.163 -15.268 1.00 41.04  ? 879  TYR   A O   1 
ATOM   4615 C  CB  . TYR   A 1 616 ? -34.348 -66.043 -12.714 1.00 34.38  ? 879  TYR   A CB  1 
ATOM   4616 C  CG  . TYR   A 1 616 ? -34.411 -65.355 -11.375 1.00 34.15  ? 879  TYR   A CG  1 
ATOM   4617 C  CD1 . TYR   A 1 616 ? -33.672 -64.209 -11.102 1.00 29.85  ? 879  TYR   A CD1 1 
ATOM   4618 C  CD2 . TYR   A 1 616 ? -35.229 -65.854 -10.381 1.00 30.57  ? 879  TYR   A CD2 1 
ATOM   4619 C  CE1 . TYR   A 1 616 ? -33.746 -63.589 -9.859  1.00 32.84  ? 879  TYR   A CE1 1 
ATOM   4620 C  CE2 . TYR   A 1 616 ? -35.318 -65.246 -9.144  1.00 30.80  ? 879  TYR   A CE2 1 
ATOM   4621 C  CZ  . TYR   A 1 616 ? -34.579 -64.113 -8.870  1.00 34.78  ? 879  TYR   A CZ  1 
ATOM   4622 O  OH  . TYR   A 1 616 ? -34.703 -63.535 -7.623  1.00 34.24  ? 879  TYR   A OH  1 
ATOM   4623 N  N   . THR   A 1 617 ? -34.138 -65.776 -15.920 1.00 43.11  ? 880  THR   A N   1 
ATOM   4624 C  CA  . THR   A 1 617 ? -33.593 -66.534 -17.083 1.00 42.02  ? 880  THR   A CA  1 
ATOM   4625 C  C   . THR   A 1 617 ? -32.175 -67.046 -16.767 1.00 40.59  ? 880  THR   A C   1 
ATOM   4626 O  O   . THR   A 1 617 ? -31.405 -66.302 -16.123 1.00 37.13  ? 880  THR   A O   1 
ATOM   4627 C  CB  . THR   A 1 617 ? -33.514 -65.613 -18.302 1.00 46.83  ? 880  THR   A CB  1 
ATOM   4628 O  OG1 . THR   A 1 617 ? -34.792 -64.986 -18.406 1.00 42.79  ? 880  THR   A OG1 1 
ATOM   4629 C  CG2 . THR   A 1 617 ? -33.149 -66.329 -19.585 1.00 44.12  ? 880  THR   A CG2 1 
ATOM   4630 N  N   . ASP   A 1 618 ? -31.848 -68.282 -17.159 1.00 38.69  ? 881  ASP   A N   1 
ATOM   4631 C  CA  . ASP   A 1 618 ? -30.463 -68.813 -17.111 1.00 39.87  ? 881  ASP   A CA  1 
ATOM   4632 C  C   . ASP   A 1 618 ? -29.783 -68.422 -18.430 1.00 37.77  ? 881  ASP   A C   1 
ATOM   4633 O  O   . ASP   A 1 618 ? -30.123 -69.022 -19.465 1.00 35.20  ? 881  ASP   A O   1 
ATOM   4634 C  CB  . ASP   A 1 618 ? -30.438 -70.326 -16.855 1.00 41.36  ? 881  ASP   A CB  1 
ATOM   4635 C  CG  . ASP   A 1 618 ? -29.047 -70.973 -16.832 1.00 50.77  ? 881  ASP   A CG  1 
ATOM   4636 O  OD1 . ASP   A 1 618 ? -28.016 -70.234 -16.620 1.00 40.81  ? 881  ASP   A OD1 1 
ATOM   4637 O  OD2 . ASP   A 1 618 ? -28.989 -72.243 -16.997 1.00 52.39  ? 881  ASP   A OD2 1 
ATOM   4638 N  N   . TYR   A 1 619 ? -28.835 -67.484 -18.393 1.00 33.53  ? 882  TYR   A N   1 
ATOM   4639 C  CA  . TYR   A 1 619 ? -28.034 -67.108 -19.585 1.00 33.22  ? 882  TYR   A CA  1 
ATOM   4640 C  C   . TYR   A 1 619 ? -26.743 -67.918 -19.683 1.00 31.90  ? 882  TYR   A C   1 
ATOM   4641 O  O   . TYR   A 1 619 ? -26.076 -67.799 -20.716 1.00 36.69  ? 882  TYR   A O   1 
ATOM   4642 C  CB  . TYR   A 1 619 ? -27.739 -65.615 -19.562 1.00 33.51  ? 882  TYR   A CB  1 
ATOM   4643 C  CG  . TYR   A 1 619 ? -28.957 -64.766 -19.761 1.00 37.06  ? 882  TYR   A CG  1 
ATOM   4644 C  CD1 . TYR   A 1 619 ? -29.541 -64.632 -21.014 1.00 37.59  ? 882  TYR   A CD1 1 
ATOM   4645 C  CD2 . TYR   A 1 619 ? -29.532 -64.102 -18.691 1.00 36.37  ? 882  TYR   A CD2 1 
ATOM   4646 C  CE1 . TYR   A 1 619 ? -30.676 -63.849 -21.197 1.00 39.17  ? 882  TYR   A CE1 1 
ATOM   4647 C  CE2 . TYR   A 1 619 ? -30.648 -63.296 -18.861 1.00 39.87  ? 882  TYR   A CE2 1 
ATOM   4648 C  CZ  . TYR   A 1 619 ? -31.219 -63.171 -20.117 1.00 38.41  ? 882  TYR   A CZ  1 
ATOM   4649 O  OH  . TYR   A 1 619 ? -32.287 -62.357 -20.261 1.00 37.37  ? 882  TYR   A OH  1 
ATOM   4650 N  N   . MET   A 1 620 ? -26.399 -68.747 -18.698 1.00 34.32  ? 883  MET   A N   1 
ATOM   4651 C  CA  . MET   A 1 620 ? -25.091 -69.472 -18.716 1.00 35.67  ? 883  MET   A CA  1 
ATOM   4652 C  C   . MET   A 1 620 ? -24.958 -70.457 -19.898 1.00 38.19  ? 883  MET   A C   1 
ATOM   4653 O  O   . MET   A 1 620 ? -23.864 -70.518 -20.471 1.00 52.88  ? 883  MET   A O   1 
ATOM   4654 C  CB  . MET   A 1 620 ? -24.778 -70.151 -17.381 1.00 33.51  ? 883  MET   A CB  1 
ATOM   4655 C  CG  . MET   A 1 620 ? -24.906 -69.243 -16.148 1.00 34.87  ? 883  MET   A CG  1 
ATOM   4656 S  SD  . MET   A 1 620 ? -24.111 -67.622 -16.298 1.00 35.44  ? 883  MET   A SD  1 
ATOM   4657 C  CE  . MET   A 1 620 ? -22.414 -68.172 -16.574 1.00 33.21  ? 883  MET   A CE  1 
ATOM   4658 N  N   . PRO   A 1 621 ? -25.984 -71.227 -20.353 1.00 46.53  ? 884  PRO   A N   1 
ATOM   4659 C  CA  . PRO   A 1 621 ? -25.857 -72.080 -21.553 1.00 44.14  ? 884  PRO   A CA  1 
ATOM   4660 C  C   . PRO   A 1 621 ? -25.635 -71.371 -22.900 1.00 42.47  ? 884  PRO   A C   1 
ATOM   4661 O  O   . PRO   A 1 621 ? -25.368 -72.050 -23.858 1.00 47.25  ? 884  PRO   A O   1 
ATOM   4662 C  CB  . PRO   A 1 621 ? -27.194 -72.859 -21.634 1.00 43.29  ? 884  PRO   A CB  1 
ATOM   4663 C  CG  . PRO   A 1 621 ? -27.776 -72.782 -20.230 1.00 41.03  ? 884  PRO   A CG  1 
ATOM   4664 C  CD  . PRO   A 1 621 ? -27.281 -71.457 -19.679 1.00 45.08  ? 884  PRO   A CD  1 
ATOM   4665 N  N   . SER   A 1 622 ? -25.659 -70.033 -22.934 1.00 39.11  ? 885  SER   A N   1 
ATOM   4666 C  CA  . SER   A 1 622 ? -25.154 -69.216 -24.071 1.00 43.75  ? 885  SER   A CA  1 
ATOM   4667 C  C   . SER   A 1 622 ? -23.625 -69.359 -24.261 1.00 46.61  ? 885  SER   A C   1 
ATOM   4668 O  O   . SER   A 1 622 ? -23.115 -68.940 -25.324 1.00 44.51  ? 885  SER   A O   1 
ATOM   4669 C  CB  . SER   A 1 622 ? -25.553 -67.764 -23.923 1.00 42.45  ? 885  SER   A CB  1 
ATOM   4670 O  OG  . SER   A 1 622 ? -24.728 -67.096 -22.981 1.00 35.90  ? 885  SER   A OG  1 
ATOM   4671 N  N   . MET   A 1 623 ? -22.936 -69.890 -23.244 0.46 48.56  ? 886  MET   A N   1 
ATOM   4672 C  CA  . MET   A 1 623 ? -21.488 -70.222 -23.273 0.46 56.88  ? 886  MET   A CA  1 
ATOM   4673 C  C   . MET   A 1 623 ? -21.336 -71.729 -23.505 0.46 61.41  ? 886  MET   A C   1 
ATOM   4674 O  O   . MET   A 1 623 ? -22.106 -72.498 -22.894 0.46 60.43  ? 886  MET   A O   1 
ATOM   4675 C  CB  . MET   A 1 623 ? -20.807 -69.838 -21.956 0.46 57.16  ? 886  MET   A CB  1 
ATOM   4676 C  CG  . MET   A 1 623 ? -21.229 -68.482 -21.423 0.46 58.44  ? 886  MET   A CG  1 
ATOM   4677 S  SD  . MET   A 1 623 ? -20.214 -67.949 -20.022 0.46 55.76  ? 886  MET   A SD  1 
ATOM   4678 C  CE  . MET   A 1 623 ? -18.741 -67.417 -20.893 0.46 56.44  ? 886  MET   A CE  1 
ATOM   4679 N  N   . LYS   A 1 624 ? -20.361 -72.121 -24.332 0.46 66.63  ? 887  LYS   A N   1 
ATOM   4680 C  CA  . LYS   A 1 624 ? -20.172 -73.509 -24.837 0.46 72.13  ? 887  LYS   A CA  1 
ATOM   4681 C  C   . LYS   A 1 624 ? -20.036 -74.491 -23.662 0.46 76.76  ? 887  LYS   A C   1 
ATOM   4682 O  O   . LYS   A 1 624 ? -20.655 -75.573 -23.730 0.46 75.32  ? 887  LYS   A O   1 
ATOM   4683 C  CB  . LYS   A 1 624 ? -18.948 -73.566 -25.759 0.46 74.29  ? 887  LYS   A CB  1 
ATOM   4684 C  CG  . LYS   A 1 624 ? -18.944 -74.715 -26.759 0.46 74.57  ? 887  LYS   A CG  1 
ATOM   4685 C  CD  . LYS   A 1 624 ? -17.702 -74.765 -27.627 0.46 76.06  ? 887  LYS   A CD  1 
ATOM   4686 C  CE  . LYS   A 1 624 ? -17.697 -73.727 -28.730 0.46 75.68  ? 887  LYS   A CE  1 
ATOM   4687 N  NZ  . LYS   A 1 624 ? -16.422 -73.741 -29.484 0.46 75.90  ? 887  LYS   A NZ  1 
ATOM   4688 N  N   . ARG   A 1 625 ? -19.270 -74.126 -22.627 0.46 81.68  ? 888  ARG   A N   1 
ATOM   4689 C  CA  . ARG   A 1 625 ? -18.911 -75.019 -21.487 0.46 85.00  ? 888  ARG   A CA  1 
ATOM   4690 C  C   . ARG   A 1 625 ? -20.152 -75.360 -20.646 0.46 85.81  ? 888  ARG   A C   1 
ATOM   4691 O  O   . ARG   A 1 625 ? -20.213 -76.501 -20.141 0.46 84.99  ? 888  ARG   A O   1 
ATOM   4692 C  CB  . ARG   A 1 625 ? -17.811 -74.389 -20.622 0.46 86.51  ? 888  ARG   A CB  1 
ATOM   4693 C  CG  . ARG   A 1 625 ? -18.219 -73.133 -19.863 0.46 87.65  ? 888  ARG   A CG  1 
ATOM   4694 C  CD  . ARG   A 1 625 ? -17.131 -72.690 -18.902 0.46 88.33  ? 888  ARG   A CD  1 
ATOM   4695 N  NE  . ARG   A 1 625 ? -17.092 -73.529 -17.709 0.46 88.37  ? 888  ARG   A NE  1 
ATOM   4696 C  CZ  . ARG   A 1 625 ? -16.106 -73.549 -16.814 0.46 87.72  ? 888  ARG   A CZ  1 
ATOM   4697 N  NH1 . ARG   A 1 625 ? -15.040 -72.777 -16.964 0.46 88.41  ? 888  ARG   A NH1 1 
ATOM   4698 N  NH2 . ARG   A 1 625 ? -16.191 -74.352 -15.767 0.46 86.29  ? 888  ARG   A NH2 1 
ATOM   4699 N  N   . PHE   A 1 626 ? -21.102 -74.424 -20.508 0.46 87.67  ? 889  PHE   A N   1 
ATOM   4700 C  CA  . PHE   A 1 626 ? -22.299 -74.546 -19.629 0.46 87.19  ? 889  PHE   A CA  1 
ATOM   4701 C  C   . PHE   A 1 626 ? -23.465 -75.204 -20.381 0.46 90.67  ? 889  PHE   A C   1 
ATOM   4702 O  O   . PHE   A 1 626 ? -24.616 -75.113 -19.900 0.46 92.30  ? 889  PHE   A O   1 
ATOM   4703 C  CB  . PHE   A 1 626 ? -22.707 -73.176 -19.077 0.46 85.15  ? 889  PHE   A CB  1 
ATOM   4704 C  CG  . PHE   A 1 626 ? -21.726 -72.580 -18.101 0.46 85.63  ? 889  PHE   A CG  1 
ATOM   4705 C  CD1 . PHE   A 1 626 ? -21.430 -73.228 -16.910 0.46 86.64  ? 889  PHE   A CD1 1 
ATOM   4706 C  CD2 . PHE   A 1 626 ? -21.097 -71.374 -18.370 0.46 85.84  ? 889  PHE   A CD2 1 
ATOM   4707 C  CE1 . PHE   A 1 626 ? -20.521 -72.686 -16.014 0.46 88.72  ? 889  PHE   A CE1 1 
ATOM   4708 C  CE2 . PHE   A 1 626 ? -20.191 -70.831 -17.472 0.46 88.25  ? 889  PHE   A CE2 1 
ATOM   4709 C  CZ  . PHE   A 1 626 ? -19.904 -71.488 -16.296 0.46 88.70  ? 889  PHE   A CZ  1 
ATOM   4710 N  N   . ARG   A 1 627 ? -23.159 -75.865 -21.496 0.46 91.49  ? 890  ARG   A N   1 
ATOM   4711 C  CA  . ARG   A 1 627 ? -24.203 -76.601 -22.253 0.46 95.77  ? 890  ARG   A CA  1 
ATOM   4712 C  C   . ARG   A 1 627 ? -24.274 -78.043 -21.736 0.46 94.75  ? 890  ARG   A C   1 
ATOM   4713 O  O   . ARG   A 1 627 ? -23.231 -78.720 -21.733 0.46 97.74  ? 890  ARG   A O   1 
ATOM   4714 C  CB  . ARG   A 1 627 ? -23.893 -76.532 -23.751 0.46 97.28  ? 890  ARG   A CB  1 
ATOM   4715 C  CG  . ARG   A 1 627 ? -23.841 -75.108 -24.285 0.46 97.23  ? 890  ARG   A CG  1 
ATOM   4716 C  CD  . ARG   A 1 627 ? -23.812 -75.004 -25.797 0.46 96.55  ? 890  ARG   A CD  1 
ATOM   4717 N  NE  . ARG   A 1 627 ? -22.659 -75.662 -26.394 0.46 97.46  ? 890  ARG   A NE  1 
ATOM   4718 C  CZ  . ARG   A 1 627 ? -22.352 -75.605 -27.684 0.46 98.34  ? 890  ARG   A CZ  1 
ATOM   4719 N  NH1 . ARG   A 1 627 ? -23.111 -74.910 -28.513 0.46 96.64  ? 890  ARG   A NH1 1 
ATOM   4720 N  NH2 . ARG   A 1 627 ? -21.286 -76.237 -28.141 0.46 97.73  ? 890  ARG   A NH2 1 
ATOM   4721 N  N   . ARG   A 1 628 ? -25.459 -78.483 -21.302 0.46 92.17  ? 891  ARG   A N   1 
ATOM   4722 C  CA  . ARG   A 1 628 ? -25.643 -79.878 -20.819 0.46 89.03  ? 891  ARG   A CA  1 
ATOM   4723 C  C   . ARG   A 1 628 ? -25.231 -80.849 -21.930 0.46 84.80  ? 891  ARG   A C   1 
ATOM   4724 O  O   . ARG   A 1 628 ? -25.312 -82.067 -21.682 0.46 78.56  ? 891  ARG   A O   1 
ATOM   4725 C  CB  . ARG   A 1 628 ? -27.102 -80.105 -20.415 0.46 87.92  ? 891  ARG   A CB  1 
ATOM   4726 C  CG  . ARG   A 1 628 ? -27.323 -81.299 -19.498 0.46 87.93  ? 891  ARG   A CG  1 
ATOM   4727 C  CD  . ARG   A 1 628 ? -26.843 -81.026 -18.087 0.46 86.13  ? 891  ARG   A CD  1 
ATOM   4728 N  NE  . ARG   A 1 628 ? -27.238 -82.068 -17.150 0.46 84.04  ? 891  ARG   A NE  1 
ATOM   4729 C  CZ  . ARG   A 1 628 ? -27.002 -82.033 -15.844 0.46 80.98  ? 891  ARG   A CZ  1 
ATOM   4730 N  NH1 . ARG   A 1 628 ? -26.370 -81.001 -15.312 0.46 79.70  ? 891  ARG   A NH1 1 
ATOM   4731 N  NH2 . ARG   A 1 628 ? -27.402 -83.029 -15.072 0.46 77.18  ? 891  ARG   A NH2 1 
HETATM 4732 ZN ZN  . ZN    B 2 .   ? -6.511  -55.116 -23.691 1.00 25.14  2 1001 ZN    A ZN  1 
HETATM 4733 ZN ZN  . ZN    C 2 .   ? -25.853 -14.370 -13.190 1.00 53.89  2 1002 ZN    A ZN  1 
HETATM 4734 O  O1  A MES   D 3 .   ? -28.513 -57.737 -0.461  0.25 694.46 ? 1003 MES   A O1  1 
HETATM 4735 O  O1  B MES   D 3 .   ? -28.326 -57.696 0.101   0.25 31.57  ? 1003 MES   A O1  1 
HETATM 4736 C  C2  A MES   D 3 .   ? -28.081 -58.100 0.841   0.25 701.34 ? 1003 MES   A C2  1 
HETATM 4737 C  C2  B MES   D 3 .   ? -27.616 -58.458 1.072   0.25 33.05  ? 1003 MES   A C2  1 
HETATM 4738 C  C3  A MES   D 3 .   ? -26.676 -57.622 1.107   0.25 701.93 ? 1003 MES   A C3  1 
HETATM 4739 C  C3  B MES   D 3 .   ? -26.115 -58.326 0.926   0.25 32.44  ? 1003 MES   A C3  1 
HETATM 4740 N  N4  A MES   D 3 .   ? -25.735 -58.180 0.086   0.25 699.31 ? 1003 MES   A N4  1 
HETATM 4741 N  N4  B MES   D 3 .   ? -25.718 -58.752 -0.446  0.25 32.42  ? 1003 MES   A N4  1 
HETATM 4742 C  C5  A MES   D 3 .   ? -26.246 -57.871 -1.286  0.25 688.26 ? 1003 MES   A C5  1 
HETATM 4743 C  C5  B MES   D 3 .   ? -26.423 -57.861 -1.413  0.25 33.35  ? 1003 MES   A C5  1 
HETATM 4744 C  C6  A MES   D 3 .   ? -27.671 -58.339 -1.432  0.25 686.72 ? 1003 MES   A C6  1 
HETATM 4745 C  C6  B MES   D 3 .   ? -27.914 -58.014 -1.224  0.25 32.63  ? 1003 MES   A C6  1 
HETATM 4746 C  C7  A MES   D 3 .   ? -24.342 -57.658 0.281   0.25 702.37 ? 1003 MES   A C7  1 
HETATM 4747 C  C7  B MES   D 3 .   ? -24.235 -58.796 -0.671  0.25 33.49  ? 1003 MES   A C7  1 
HETATM 4748 C  C8  A MES   D 3 .   ? -23.284 -58.540 -0.350  0.25 710.76 ? 1003 MES   A C8  1 
HETATM 4749 C  C8  B MES   D 3 .   ? -23.442 -57.744 0.078   0.25 34.54  ? 1003 MES   A C8  1 
HETATM 4750 S  S   A MES   D 3 .   ? -21.657 -57.829 -0.247  0.25 724.72 ? 1003 MES   A S   1 
HETATM 4751 S  S   B MES   D 3 .   ? -21.689 -58.044 -0.007  0.25 37.43  ? 1003 MES   A S   1 
HETATM 4752 O  O1S A MES   D 3 .   ? -21.099 -58.287 0.995   0.25 735.48 ? 1003 MES   A O1S 1 
HETATM 4753 O  O1S B MES   D 3 .   ? -21.568 -59.486 -0.232  0.25 32.77  ? 1003 MES   A O1S 1 
HETATM 4754 O  O2S A MES   D 3 .   ? -20.938 -58.318 -1.389  0.25 720.46 ? 1003 MES   A O2S 1 
HETATM 4755 O  O2S B MES   D 3 .   ? -21.196 -57.299 -1.126  0.25 34.82  ? 1003 MES   A O2S 1 
HETATM 4756 O  O3S A MES   D 3 .   ? -21.843 -56.405 -0.277  0.25 719.42 ? 1003 MES   A O3S 1 
HETATM 4757 O  O3S B MES   D 3 .   ? -21.151 -57.644 1.250   0.25 33.33  ? 1003 MES   A O3S 1 
HETATM 4758 S  S   . DMS   E 4 .   ? -26.849 -61.879 -21.035 1.00 49.38  ? 1004 DMS   A S   1 
HETATM 4759 O  O   . DMS   E 4 .   ? -26.854 -62.542 -22.414 1.00 47.95  ? 1004 DMS   A O   1 
HETATM 4760 C  C1  . DMS   E 4 .   ? -28.002 -60.546 -21.147 1.00 43.42  ? 1004 DMS   A C1  1 
HETATM 4761 C  C2  . DMS   E 4 .   ? -25.337 -60.907 -21.029 1.00 44.99  ? 1004 DMS   A C2  1 
HETATM 4762 S  S   . DMS   F 4 .   ? -15.907 -69.311 -28.842 1.00 100.02 ? 1005 DMS   A S   1 
HETATM 4763 O  O   . DMS   F 4 .   ? -16.306 -67.860 -28.936 1.00 78.07  ? 1005 DMS   A O   1 
HETATM 4764 C  C1  . DMS   F 4 .   ? -16.963 -70.034 -27.606 1.00 91.01  ? 1005 DMS   A C1  1 
HETATM 4765 C  C2  . DMS   F 4 .   ? -14.372 -69.366 -27.946 1.00 96.23  ? 1005 DMS   A C2  1 
HETATM 4766 P  P   . PO4   G 5 .   ? -3.983  -39.310 -23.846 1.00 67.10  ? 1006 PO4   A P   1 
HETATM 4767 O  O1  . PO4   G 5 .   ? -2.654  -40.039 -23.238 1.00 43.59  ? 1006 PO4   A O1  1 
HETATM 4768 O  O2  . PO4   G 5 .   ? -3.624  -37.868 -24.470 1.00 36.94  ? 1006 PO4   A O2  1 
HETATM 4769 O  O3  . PO4   G 5 .   ? -4.714  -40.194 -24.943 1.00 42.98  ? 1006 PO4   A O3  1 
HETATM 4770 O  O4  . PO4   G 5 .   ? -4.902  -39.167 -22.717 1.00 50.46  ? 1006 PO4   A O4  1 
HETATM 4771 P  P   . PO4   H 5 .   ? -17.949 -9.358  -28.852 1.00 115.35 ? 1007 PO4   A P   1 
HETATM 4772 O  O1  . PO4   H 5 .   ? -17.668 -9.853  -27.408 1.00 79.96  ? 1007 PO4   A O1  1 
HETATM 4773 O  O2  . PO4   H 5 .   ? -16.626 -9.097  -29.587 1.00 99.08  ? 1007 PO4   A O2  1 
HETATM 4774 O  O3  . PO4   H 5 .   ? -18.769 -10.415 -29.621 1.00 92.46  ? 1007 PO4   A O3  1 
HETATM 4775 O  O4  . PO4   H 5 .   ? -18.745 -8.052  -28.794 1.00 91.33  ? 1007 PO4   A O4  1 
HETATM 4776 C  C1  . PEG   I 6 .   ? -16.466 -43.337 -40.977 1.00 68.12  ? 1008 PEG   A C1  1 
HETATM 4777 O  O1  . PEG   I 6 .   ? -17.843 -43.668 -40.909 1.00 66.51  ? 1008 PEG   A O1  1 
HETATM 4778 C  C2  . PEG   I 6 .   ? -15.806 -43.914 -42.186 1.00 71.90  ? 1008 PEG   A C2  1 
HETATM 4779 O  O2  . PEG   I 6 .   ? -16.270 -45.247 -42.382 1.00 74.88  ? 1008 PEG   A O2  1 
HETATM 4780 C  C3  . PEG   I 6 .   ? -16.188 -45.685 -43.733 1.00 76.76  ? 1008 PEG   A C3  1 
HETATM 4781 C  C4  . PEG   I 6 .   ? -15.133 -46.731 -43.859 1.00 82.74  ? 1008 PEG   A C4  1 
HETATM 4782 O  O4  . PEG   I 6 .   ? -15.685 -48.006 -44.140 1.00 81.64  ? 1008 PEG   A O4  1 
HETATM 4783 CL CL  . CL    J 7 .   ? 4.234   -48.826 -29.872 1.00 44.71  ? 1009 CL    A CL  1 
HETATM 4784 N  N1  . A1BFU K 8 .   ? -5.697  -71.561 -19.828 0.46 85.81  ? 1010 A1BFU A N1  1 
HETATM 4785 C  C4  . A1BFU K 8 .   ? -5.090  -70.453 -19.044 0.46 82.43  ? 1010 A1BFU A C4  1 
HETATM 4786 C  C5  . A1BFU K 8 .   ? -8.445  -70.777 -21.113 0.46 84.79  ? 1010 A1BFU A C5  1 
HETATM 4787 C  C6  . A1BFU K 8 .   ? -9.952  -70.710 -21.240 0.46 83.50  ? 1010 A1BFU A C6  1 
HETATM 4788 C  C7  . A1BFU K 8 .   ? -10.426 -70.726 -19.808 0.46 84.55  ? 1010 A1BFU A C7  1 
HETATM 4789 C  C8  . A1BFU K 8 .   ? -9.526  -71.752 -19.152 0.46 84.95  ? 1010 A1BFU A C8  1 
HETATM 4790 C  C1  . A1BFU K 8 .   ? -2.946  -68.454 -21.201 0.46 75.94  ? 1010 A1BFU A C1  1 
HETATM 4791 C  C2  . A1BFU K 8 .   ? -4.640  -69.951 -20.426 0.46 81.18  ? 1010 A1BFU A C2  1 
HETATM 4792 C  C3  . A1BFU K 8 .   ? -4.659  -71.418 -20.882 0.46 81.80  ? 1010 A1BFU A C3  1 
HETATM 4793 N  N2  . A1BFU K 8 .   ? -8.259  -71.589 -19.894 0.46 85.46  ? 1010 A1BFU A N2  1 
HETATM 4794 O  O1  . A1BFU K 8 .   ? -3.260  -69.582 -20.400 0.46 76.39  ? 1010 A1BFU A O1  1 
HETATM 4795 O  O2  . A1BFU K 8 .   ? -6.951  -73.469 -20.700 0.46 89.48  ? 1010 A1BFU A O2  1 
HETATM 4796 O  O3  . A1BFU K 8 .   ? -7.006  -72.928 -18.292 0.46 91.64  ? 1010 A1BFU A O3  1 
HETATM 4797 S  S1  . A1BFU K 8 .   ? -6.978  -72.513 -19.650 0.46 90.25  ? 1010 A1BFU A S1  1 
HETATM 4798 CL CL  . CL    L 7 .   ? -23.046 -47.959 -16.326 0.48 34.97  ? 1011 CL    A CL  1 
HETATM 4799 O  O   . HOH   M 9 .   ? 5.934   -44.737 -35.536 1.00 45.90  ? 1101 HOH   A O   1 
HETATM 4800 O  O   . HOH   M 9 .   ? -15.466 -21.829 -18.947 1.00 42.35  ? 1102 HOH   A O   1 
HETATM 4801 O  O   . HOH   M 9 .   ? -34.326 -20.272 -23.299 0.50 33.27  ? 1103 HOH   A O   1 
HETATM 4802 O  O   . HOH   M 9 .   ? -39.610 -63.830 -19.621 1.00 57.66  ? 1104 HOH   A O   1 
HETATM 4803 O  O   . HOH   M 9 .   ? -28.865 -62.760 -25.319 1.00 33.99  ? 1105 HOH   A O   1 
HETATM 4804 O  O   . HOH   M 9 .   ? -32.629 -51.900 -27.276 1.00 48.96  ? 1106 HOH   A O   1 
HETATM 4805 O  O   . HOH   M 9 .   ? -14.542 -17.055 -36.222 1.00 49.49  ? 1107 HOH   A O   1 
HETATM 4806 O  O   . HOH   M 9 .   ? -27.343 -65.394 -39.863 1.00 52.18  ? 1108 HOH   A O   1 
HETATM 4807 O  O   . HOH   M 9 .   ? -4.255  -53.492 -28.099 1.00 35.69  ? 1109 HOH   A O   1 
HETATM 4808 O  O   . HOH   M 9 .   ? -23.357 -64.684 -38.823 1.00 45.03  ? 1110 HOH   A O   1 
HETATM 4809 O  O   . HOH   M 9 .   ? -19.924 -66.197 -37.852 1.00 53.97  ? 1111 HOH   A O   1 
HETATM 4810 O  O   . HOH   M 9 .   ? -2.390  -72.181 -13.487 0.46 38.03  ? 1112 HOH   A O   1 
HETATM 4811 O  O   . HOH   M 9 .   ? -31.823 -57.210 -21.757 1.00 34.82  ? 1113 HOH   A O   1 
HETATM 4812 O  O   . HOH   M 9 .   ? -6.862  -20.220 -26.952 1.00 42.64  ? 1114 HOH   A O   1 
HETATM 4813 O  O   . HOH   M 9 .   ? -22.261 -53.126 -46.801 1.00 57.09  ? 1115 HOH   A O   1 
HETATM 4814 O  O   . HOH   M 9 .   ? -4.907  -15.257 -28.264 1.00 44.92  ? 1116 HOH   A O   1 
HETATM 4815 O  O   . HOH   M 9 .   ? -1.787  -41.246 -21.227 1.00 53.51  ? 1117 HOH   A O   1 
HETATM 4816 O  O   . HOH   M 9 .   ? -12.783 -21.677 -41.484 1.00 50.68  ? 1118 HOH   A O   1 
HETATM 4817 O  O   . HOH   M 9 .   ? -7.364  -42.608 -42.736 1.00 59.75  ? 1119 HOH   A O   1 
HETATM 4818 O  O   . HOH   M 9 .   ? -3.490  -15.288 -20.323 1.00 46.91  ? 1120 HOH   A O   1 
HETATM 4819 O  O   . HOH   M 9 .   ? -40.173 -61.104 -11.381 1.00 28.62  ? 1121 HOH   A O   1 
HETATM 4820 O  O   . HOH   M 9 .   ? -32.385 -60.157 -19.005 1.00 44.61  ? 1122 HOH   A O   1 
HETATM 4821 O  O   . HOH   M 9 .   ? -24.625 -13.788 -4.855  1.00 45.74  ? 1123 HOH   A O   1 
HETATM 4822 O  O   . HOH   M 9 .   ? 0.054   -32.689 -27.726 1.00 29.60  ? 1124 HOH   A O   1 
HETATM 4823 O  O   . HOH   M 9 .   ? -5.480  -60.019 -0.888  1.00 38.11  ? 1125 HOH   A O   1 
HETATM 4824 O  O   . HOH   M 9 .   ? -4.443  -54.139 -11.860 1.00 49.15  ? 1126 HOH   A O   1 
HETATM 4825 O  O   . HOH   M 9 .   ? -22.136 -9.930  -9.435  1.00 52.15  ? 1127 HOH   A O   1 
HETATM 4826 O  O   . HOH   M 9 .   ? -28.631 -69.401 -14.081 1.00 52.33  ? 1128 HOH   A O   1 
HETATM 4827 O  O   . HOH   M 9 .   ? -14.716 -21.028 -16.785 1.00 53.04  ? 1129 HOH   A O   1 
HETATM 4828 O  O   . HOH   M 9 .   ? -26.584 -25.585 -33.355 1.00 31.67  ? 1130 HOH   A O   1 
HETATM 4829 O  O   . HOH   M 9 .   ? 6.687   -35.191 -43.610 1.00 49.61  ? 1131 HOH   A O   1 
HETATM 4830 O  O   . HOH   M 9 .   ? 1.593   -32.127 -38.783 1.00 31.44  ? 1132 HOH   A O   1 
HETATM 4831 O  O   . HOH   M 9 .   ? -21.364 -65.938 -4.515  1.00 52.83  ? 1133 HOH   A O   1 
HETATM 4832 O  O   . HOH   M 9 .   ? -38.151 -67.491 -8.412  1.00 40.83  ? 1134 HOH   A O   1 
HETATM 4833 O  O   . HOH   M 9 .   ? -10.896 -62.185 -18.736 1.00 21.26  ? 1135 HOH   A O   1 
HETATM 4834 O  O   . HOH   M 9 .   ? -34.471 -59.335 -22.824 1.00 58.25  ? 1136 HOH   A O   1 
HETATM 4835 O  O   . HOH   M 9 .   ? -7.885  -48.595 0.828   1.00 47.89  ? 1137 HOH   A O   1 
HETATM 4836 O  O   . HOH   M 9 .   ? -34.702 -62.746 0.585   1.00 23.84  ? 1138 HOH   A O   1 
HETATM 4837 O  O   . HOH   M 9 .   ? -29.514 -43.918 -5.275  1.00 64.62  ? 1139 HOH   A O   1 
HETATM 4838 O  O   . HOH   M 9 .   ? -29.776 -50.180 -27.148 1.00 48.78  ? 1140 HOH   A O   1 
HETATM 4839 O  O   . HOH   M 9 .   ? -5.948  -68.329 -27.419 1.00 31.69  ? 1141 HOH   A O   1 
HETATM 4840 O  O   . HOH   M 9 .   ? -3.997  -57.225 -9.795  1.00 37.58  ? 1142 HOH   A O   1 
HETATM 4841 O  O   . HOH   M 9 .   ? -27.954 -47.072 -0.078  1.00 48.02  ? 1143 HOH   A O   1 
HETATM 4842 O  O   . HOH   M 9 .   ? -26.490 -71.173 -3.729  1.00 42.84  ? 1144 HOH   A O   1 
HETATM 4843 O  O   . HOH   M 9 .   ? -20.532 -29.216 -25.004 1.00 43.72  ? 1145 HOH   A O   1 
HETATM 4844 O  O   . HOH   M 9 .   ? -40.114 -24.163 -26.563 1.00 51.58  ? 1146 HOH   A O   1 
HETATM 4845 O  O   . HOH   M 9 .   ? -28.738 -45.778 2.557   1.00 51.94  ? 1147 HOH   A O   1 
HETATM 4846 O  O   . HOH   M 9 .   ? 0.174   -68.042 -18.929 0.46 27.12  ? 1148 HOH   A O   1 
HETATM 4847 O  O   . HOH   M 9 .   ? 11.378  -34.592 -33.045 1.00 38.89  ? 1149 HOH   A O   1 
HETATM 4848 O  O   . HOH   M 9 .   ? -5.780  -58.333 -37.166 1.00 50.94  ? 1150 HOH   A O   1 
HETATM 4849 O  O   . HOH   M 9 .   ? 7.201   -49.607 -30.849 1.00 57.70  ? 1151 HOH   A O   1 
HETATM 4850 O  O   . HOH   M 9 .   ? -14.544 -44.362 -3.928  1.00 61.92  ? 1152 HOH   A O   1 
HETATM 4851 O  O   . HOH   M 9 .   ? 5.957   -31.159 -19.193 1.00 43.35  ? 1153 HOH   A O   1 
HETATM 4852 O  O   . HOH   M 9 .   ? 1.091   -21.446 -45.418 1.00 54.52  ? 1154 HOH   A O   1 
HETATM 4853 O  O   . HOH   M 9 .   ? -30.157 -56.675 -34.225 1.00 56.20  ? 1155 HOH   A O   1 
HETATM 4854 O  O   . HOH   M 9 .   ? -3.317  -19.938 -23.316 1.00 37.88  ? 1156 HOH   A O   1 
HETATM 4855 O  O   . HOH   M 9 .   ? 10.118  -25.616 -32.085 1.00 53.48  ? 1157 HOH   A O   1 
HETATM 4856 O  O   . HOH   M 9 .   ? -4.364  -65.294 -15.071 1.00 37.23  ? 1158 HOH   A O   1 
HETATM 4857 O  O   . HOH   M 9 .   ? 2.721   -39.276 -26.958 1.00 31.96  ? 1159 HOH   A O   1 
HETATM 4858 O  O   . HOH   M 9 .   ? 5.429   -29.895 -21.536 1.00 30.37  ? 1160 HOH   A O   1 
HETATM 4859 O  O   . HOH   M 9 .   ? -24.427 -69.034 -27.635 1.00 43.83  ? 1161 HOH   A O   1 
HETATM 4860 O  O   . HOH   M 9 .   ? -22.980 -20.775 -37.889 1.00 44.63  ? 1162 HOH   A O   1 
HETATM 4861 O  O   . HOH   M 9 .   ? -12.833 -42.420 -38.889 1.00 48.25  ? 1163 HOH   A O   1 
HETATM 4862 O  O   . HOH   M 9 .   ? -10.909 -47.995 -39.180 1.00 29.91  ? 1164 HOH   A O   1 
HETATM 4863 O  O   . HOH   M 9 .   ? -13.202 -68.470 -6.235  1.00 39.67  ? 1165 HOH   A O   1 
HETATM 4864 O  O   . HOH   M 9 .   ? -12.313 -58.020 -0.000  0.50 27.88  ? 1166 HOH   A O   1 
HETATM 4865 O  O   . HOH   M 9 .   ? -6.326  -36.794 -20.563 1.00 48.42  ? 1167 HOH   A O   1 
HETATM 4866 O  O   . HOH   M 9 .   ? -20.599 -47.007 -10.276 1.00 49.08  ? 1168 HOH   A O   1 
HETATM 4867 O  O   . HOH   M 9 .   ? -18.829 -65.082 -7.133  1.00 22.73  ? 1169 HOH   A O   1 
HETATM 4868 O  O   . HOH   M 9 .   ? -32.810 -63.253 -15.175 1.00 28.85  ? 1170 HOH   A O   1 
HETATM 4869 O  O   . HOH   M 9 .   ? -32.700 -48.782 -18.828 1.00 49.15  ? 1171 HOH   A O   1 
HETATM 4870 O  O   . HOH   M 9 .   ? -38.878 -60.784 -4.380  1.00 36.98  ? 1172 HOH   A O   1 
HETATM 4871 O  O   . HOH   M 9 .   ? -9.795  -63.818 -33.152 1.00 47.67  ? 1173 HOH   A O   1 
HETATM 4872 O  O   . HOH   M 9 .   ? -36.830 -50.119 -5.377  1.00 39.26  ? 1174 HOH   A O   1 
HETATM 4873 O  O   . HOH   M 9 .   ? -0.502  -10.763 -29.808 1.00 56.82  ? 1175 HOH   A O   1 
HETATM 4874 O  O   . HOH   M 9 .   ? -12.948 -53.214 -40.563 1.00 52.98  ? 1176 HOH   A O   1 
HETATM 4875 O  O   . HOH   M 9 .   ? -3.089  -55.097 -18.051 1.00 30.09  ? 1177 HOH   A O   1 
HETATM 4876 O  O   . HOH   M 9 .   ? 4.874   -16.082 -21.419 1.00 64.20  ? 1178 HOH   A O   1 
HETATM 4877 O  O   . HOH   M 9 .   ? -39.622 -55.192 -6.354  1.00 41.81  ? 1179 HOH   A O   1 
HETATM 4878 O  O   . HOH   M 9 .   ? -12.301 -36.760 -39.478 1.00 32.60  ? 1180 HOH   A O   1 
HETATM 4879 O  O   . HOH   M 9 .   ? -16.956 -34.781 -42.185 1.00 68.02  ? 1181 HOH   A O   1 
HETATM 4880 O  O   . HOH   M 9 .   ? -29.021 -17.393 -20.726 1.00 51.99  ? 1182 HOH   A O   1 
HETATM 4881 O  O   . HOH   M 9 .   ? -9.114  -58.853 -13.231 1.00 27.93  ? 1183 HOH   A O   1 
HETATM 4882 O  O   . HOH   M 9 .   ? -22.617 -27.425 -19.260 1.00 53.42  ? 1184 HOH   A O   1 
HETATM 4883 O  O   . HOH   M 9 .   ? -21.524 -49.146 -34.880 1.00 48.55  ? 1185 HOH   A O   1 
HETATM 4884 O  O   . HOH   M 9 .   ? 0.692   -70.053 -20.835 0.46 41.12  ? 1186 HOH   A O   1 
HETATM 4885 O  O   . HOH   M 9 .   ? -17.911 -65.603 -36.228 1.00 51.00  ? 1187 HOH   A O   1 
HETATM 4886 O  O   . HOH   M 9 .   ? -13.620 -74.235 -14.131 1.00 47.23  ? 1188 HOH   A O   1 
HETATM 4887 O  O   . HOH   M 9 .   ? 10.453  -38.627 -29.882 1.00 54.46  ? 1189 HOH   A O   1 
HETATM 4888 O  O   . HOH   M 9 .   ? -14.920 -34.673 -29.009 1.00 25.32  ? 1190 HOH   A O   1 
HETATM 4889 O  O   . HOH   M 9 .   ? -22.607 -65.653 -23.857 1.00 37.43  ? 1191 HOH   A O   1 
HETATM 4890 O  O   . HOH   M 9 .   ? -8.442  -64.673 -6.985  1.00 34.81  ? 1192 HOH   A O   1 
HETATM 4891 O  O   . HOH   M 9 .   ? 10.555  -26.798 -29.222 1.00 38.34  ? 1193 HOH   A O   1 
HETATM 4892 O  O   . HOH   M 9 .   ? -35.107 -49.962 -12.911 1.00 45.25  ? 1194 HOH   A O   1 
HETATM 4893 O  O   . HOH   M 9 .   ? -7.355  -47.117 -18.040 1.00 38.70  ? 1195 HOH   A O   1 
HETATM 4894 O  O   . HOH   M 9 .   ? -18.030 -62.026 -3.016  1.00 26.49  ? 1196 HOH   A O   1 
HETATM 4895 O  O   . HOH   M 9 .   ? -19.071 -69.620 -8.233  1.00 27.03  ? 1197 HOH   A O   1 
HETATM 4896 O  O   . HOH   M 9 .   ? -9.338  -21.324 -27.008 1.00 34.49  ? 1198 HOH   A O   1 
HETATM 4897 O  O   . HOH   M 9 .   ? -26.375 -30.258 -23.358 1.00 48.80  ? 1199 HOH   A O   1 
HETATM 4898 O  O   . HOH   M 9 .   ? -22.451 -50.938 -9.098  1.00 31.57  ? 1200 HOH   A O   1 
HETATM 4899 O  O   . HOH   M 9 .   ? 0.037   -31.057 -23.007 1.00 33.07  ? 1201 HOH   A O   1 
HETATM 4900 O  O   . HOH   M 9 .   ? 5.848   -32.749 -37.776 1.00 43.18  ? 1202 HOH   A O   1 
HETATM 4901 O  O   . HOH   M 9 .   ? -19.484 -17.025 -10.947 1.00 47.29  ? 1203 HOH   A O   1 
HETATM 4902 O  O   . HOH   M 9 .   ? -38.879 -56.994 -20.295 1.00 48.52  ? 1204 HOH   A O   1 
HETATM 4903 O  O   . HOH   M 9 .   ? -28.210 -48.969 -31.721 1.00 51.22  ? 1205 HOH   A O   1 
HETATM 4904 O  O   . HOH   M 9 .   ? -8.696  -26.210 -44.510 1.00 42.36  ? 1206 HOH   A O   1 
HETATM 4905 O  O   . HOH   M 9 .   ? -15.192 -54.038 -39.674 1.00 43.98  ? 1207 HOH   A O   1 
HETATM 4906 O  O   . HOH   M 9 .   ? -38.195 -60.740 -14.430 1.00 43.65  ? 1208 HOH   A O   1 
HETATM 4907 O  O   . HOH   M 9 .   ? -22.192 -74.155 -11.592 1.00 35.44  ? 1209 HOH   A O   1 
HETATM 4908 O  O   . HOH   M 9 .   ? -35.782 -66.274 -0.680  1.00 39.05  ? 1210 HOH   A O   1 
HETATM 4909 O  O   . HOH   M 9 .   ? -28.301 -49.775 0.160   1.00 39.87  ? 1211 HOH   A O   1 
HETATM 4910 O  O   . HOH   M 9 .   ? 1.041   -41.703 -24.421 1.00 41.91  ? 1212 HOH   A O   1 
HETATM 4911 O  O   . HOH   M 9 .   ? -22.004 -31.310 -39.725 1.00 44.55  ? 1213 HOH   A O   1 
HETATM 4912 O  O   . HOH   M 9 .   ? -14.636 -63.889 -0.440  1.00 33.07  ? 1214 HOH   A O   1 
HETATM 4913 O  O   . HOH   M 9 .   ? -19.447 -27.148 -40.003 1.00 34.40  ? 1215 HOH   A O   1 
HETATM 4914 O  O   . HOH   M 9 .   ? -13.905 -49.017 -32.283 0.48 39.35  ? 1216 HOH   A O   1 
HETATM 4915 O  O   . HOH   M 9 .   ? -7.414  -49.724 -6.285  1.00 57.15  ? 1217 HOH   A O   1 
HETATM 4916 O  O   . HOH   M 9 .   ? -24.965 -53.370 -1.927  1.00 31.80  ? 1218 HOH   A O   1 
HETATM 4917 O  O   . HOH   M 9 .   ? 5.868   -38.821 -24.198 1.00 51.75  ? 1219 HOH   A O   1 
HETATM 4918 O  O   . HOH   M 9 .   ? -19.178 -20.533 -40.581 1.00 42.67  ? 1220 HOH   A O   1 
HETATM 4919 O  O   . HOH   M 9 .   ? -34.351 -28.761 -30.070 1.00 50.41  ? 1221 HOH   A O   1 
HETATM 4920 O  O   . HOH   M 9 .   ? -29.404 -63.715 -34.154 1.00 61.92  ? 1222 HOH   A O   1 
HETATM 4921 O  O   . HOH   M 9 .   ? 4.324   -26.528 -29.301 1.00 37.59  ? 1223 HOH   A O   1 
HETATM 4922 O  O   . HOH   M 9 .   ? -4.081  -22.866 -25.183 1.00 36.43  ? 1224 HOH   A O   1 
HETATM 4923 O  O   . HOH   M 9 .   ? 4.179   -28.834 -44.264 1.00 43.12  ? 1225 HOH   A O   1 
HETATM 4924 O  O   . HOH   M 9 .   ? -20.660 -19.465 -38.683 1.00 58.69  ? 1226 HOH   A O   1 
HETATM 4925 O  O   . HOH   M 9 .   ? -42.503 -62.744 -5.183  1.00 46.67  ? 1227 HOH   A O   1 
HETATM 4926 O  O   . HOH   M 9 .   ? -5.217  -48.582 -28.582 1.00 36.53  ? 1228 HOH   A O   1 
HETATM 4927 O  O   . HOH   M 9 .   ? -31.690 -59.807 -15.880 1.00 37.68  ? 1229 HOH   A O   1 
HETATM 4928 O  O   . HOH   M 9 .   ? -33.491 -57.335 -19.620 1.00 45.26  ? 1230 HOH   A O   1 
HETATM 4929 O  O   . HOH   M 9 .   ? -8.831  -63.797 -31.094 1.00 47.28  ? 1231 HOH   A O   1 
HETATM 4930 O  O   . HOH   M 9 .   ? -13.697 -51.192 -43.101 1.00 53.29  ? 1232 HOH   A O   1 
HETATM 4931 O  O   . HOH   M 9 .   ? -0.569  -35.631 -28.001 1.00 37.52  ? 1233 HOH   A O   1 
HETATM 4932 O  O   . HOH   M 9 .   ? -27.849 -22.826 -26.572 1.00 35.41  ? 1234 HOH   A O   1 
HETATM 4933 O  O   . HOH   M 9 .   ? -20.733 -31.476 -29.321 1.00 41.39  ? 1235 HOH   A O   1 
HETATM 4934 O  O   . HOH   M 9 .   ? -5.709  -32.792 -17.369 1.00 44.75  ? 1236 HOH   A O   1 
HETATM 4935 O  O   . HOH   M 9 .   ? -18.486 -75.918 -16.366 1.00 54.10  ? 1237 HOH   A O   1 
HETATM 4936 O  O   . HOH   M 9 .   ? -16.981 -51.723 -15.468 1.00 20.41  ? 1238 HOH   A O   1 
HETATM 4937 O  O   . HOH   M 9 .   ? -27.770 -16.589 -32.363 1.00 41.18  ? 1239 HOH   A O   1 
HETATM 4938 O  O   . HOH   M 9 .   ? -23.057 -75.144 -9.125  1.00 40.89  ? 1240 HOH   A O   1 
HETATM 4939 O  O   . HOH   M 9 .   ? -38.009 -37.840 -26.287 1.00 48.48  ? 1241 HOH   A O   1 
HETATM 4940 O  O   . HOH   M 9 .   ? -24.559 -30.331 -39.899 1.00 56.10  ? 1242 HOH   A O   1 
HETATM 4941 O  O   . HOH   M 9 .   ? -5.903  -50.225 -18.931 1.00 37.64  ? 1243 HOH   A O   1 
HETATM 4942 O  O   . HOH   M 9 .   ? -15.575 -26.962 -46.041 1.00 45.23  ? 1244 HOH   A O   1 
HETATM 4943 O  O   . HOH   M 9 .   ? -21.154 -64.916 -40.869 1.00 45.33  ? 1245 HOH   A O   1 
HETATM 4944 O  O   . HOH   M 9 .   ? -41.137 -58.020 -10.121 0.50 34.98  ? 1246 HOH   A O   1 
HETATM 4945 O  O   . HOH   M 9 .   ? -23.070 -27.425 -24.667 1.00 49.85  ? 1247 HOH   A O   1 
HETATM 4946 O  O   . HOH   M 9 .   ? -31.082 -44.877 -15.699 1.00 48.80  ? 1248 HOH   A O   1 
HETATM 4947 O  O   . HOH   M 9 .   ? -8.395  -16.805 -39.140 1.00 47.66  ? 1249 HOH   A O   1 
HETATM 4948 O  O   . HOH   M 9 .   ? -15.475 -65.616 -33.840 1.00 53.77  ? 1250 HOH   A O   1 
HETATM 4949 O  O   . HOH   M 9 .   ? -22.933 -33.488 -36.973 1.00 32.21  ? 1251 HOH   A O   1 
HETATM 4950 O  O   . HOH   M 9 .   ? -17.530 -30.958 -41.621 1.00 52.71  ? 1252 HOH   A O   1 
HETATM 4951 O  O   . HOH   M 9 .   ? -38.857 -54.749 -18.940 1.00 40.08  ? 1253 HOH   A O   1 
HETATM 4952 O  O   . HOH   M 9 .   ? -14.120 -52.044 -5.850  1.00 26.12  ? 1254 HOH   A O   1 
HETATM 4953 O  O   . HOH   M 9 .   ? -14.869 -54.157 -3.988  1.00 27.89  ? 1255 HOH   A O   1 
HETATM 4954 O  O   . HOH   M 9 .   ? -4.212  -56.839 -13.448 1.00 45.72  ? 1256 HOH   A O   1 
HETATM 4955 O  O   . HOH   M 9 .   ? 7.813   -42.983 -36.057 1.00 43.33  ? 1257 HOH   A O   1 
HETATM 4956 O  O   . HOH   M 9 .   ? 9.282   -24.065 -36.084 1.00 55.67  ? 1258 HOH   A O   1 
HETATM 4957 O  O   . HOH   M 9 .   ? -13.701 -53.466 -1.577  1.00 27.47  ? 1259 HOH   A O   1 
HETATM 4958 O  O   . HOH   M 9 .   ? -35.732 -53.887 -3.256  1.00 34.54  ? 1260 HOH   A O   1 
HETATM 4959 O  O   . HOH   M 9 .   ? -14.236 -56.198 -1.528  1.00 25.67  ? 1261 HOH   A O   1 
HETATM 4960 O  O   . HOH   M 9 .   ? -27.218 -15.223 -19.975 1.00 49.90  ? 1262 HOH   A O   1 
HETATM 4961 O  O   . HOH   M 9 .   ? -30.032 -60.611 -23.032 1.00 33.13  ? 1263 HOH   A O   1 
HETATM 4962 O  O   . HOH   M 9 .   ? -21.466 -41.244 -35.269 1.00 49.88  ? 1264 HOH   A O   1 
HETATM 4963 O  O   . HOH   M 9 .   ? -36.240 -58.277 -20.800 1.00 47.67  ? 1265 HOH   A O   1 
HETATM 4964 O  O   . HOH   M 9 .   ? 7.914   -21.958 -24.287 1.00 46.26  ? 1266 HOH   A O   1 
HETATM 4965 O  O   . HOH   M 9 .   ? 10.473  -29.387 -34.130 1.00 47.58  ? 1267 HOH   A O   1 
HETATM 4966 O  O   . HOH   M 9 .   ? -40.057 -54.883 -14.807 1.00 48.66  ? 1268 HOH   A O   1 
HETATM 4967 O  O   . HOH   M 9 .   ? -20.000 -37.855 -36.619 1.00 30.99  ? 1269 HOH   A O   1 
HETATM 4968 O  O   . HOH   M 9 .   ? -5.590  -59.050 -12.161 1.00 42.10  ? 1270 HOH   A O   1 
HETATM 4969 O  O   . HOH   M 9 .   ? -5.801  -48.896 -21.220 1.00 28.11  ? 1271 HOH   A O   1 
HETATM 4970 O  O   . HOH   M 9 .   ? -4.851  -56.245 -31.600 1.00 27.51  ? 1272 HOH   A O   1 
HETATM 4971 O  O   . HOH   M 9 .   ? 0.211   -23.658 -16.943 1.00 57.91  ? 1273 HOH   A O   1 
HETATM 4972 O  O   . HOH   M 9 .   ? -20.582 -67.123 -25.311 1.00 33.25  ? 1274 HOH   A O   1 
HETATM 4973 O  O   . HOH   M 9 .   ? -27.662 -52.204 -41.801 1.00 49.47  ? 1275 HOH   A O   1 
HETATM 4974 O  O   . HOH   M 9 .   ? -3.371  -54.854 -36.056 1.00 57.65  ? 1276 HOH   A O   1 
HETATM 4975 O  O   . HOH   M 9 .   ? -8.841  -37.065 -19.506 1.00 52.95  ? 1277 HOH   A O   1 
HETATM 4976 O  O   . HOH   M 9 .   ? -4.508  -62.231 -4.673  1.00 37.49  ? 1278 HOH   A O   1 
HETATM 4977 O  O   . HOH   M 9 .   ? 3.355   -33.999 -14.152 1.00 49.92  ? 1279 HOH   A O   1 
HETATM 4978 O  O   . HOH   M 9 .   ? 8.578   -40.505 -31.673 1.00 46.99  ? 1280 HOH   A O   1 
HETATM 4979 O  O   . HOH   M 9 .   ? 3.612   -31.303 -37.111 1.00 30.12  ? 1281 HOH   A O   1 
HETATM 4980 O  O   . HOH   M 9 .   ? -0.064  -48.129 -36.184 1.00 38.35  ? 1282 HOH   A O   1 
HETATM 4981 O  O   . HOH   M 9 .   ? -39.586 -64.359 -2.008  1.00 51.20  ? 1283 HOH   A O   1 
HETATM 4982 O  O   . HOH   M 9 .   ? -17.500 -41.716 -36.989 1.00 49.15  ? 1284 HOH   A O   1 
HETATM 4983 O  O   . HOH   M 9 .   ? -2.628  -57.777 -27.463 1.00 30.03  ? 1285 HOH   A O   1 
HETATM 4984 O  O   . HOH   M 9 .   ? -17.299 -57.108 -43.776 1.00 35.04  ? 1286 HOH   A O   1 
HETATM 4985 O  O   . HOH   M 9 .   ? 8.457   -45.041 -29.737 1.00 66.05  ? 1287 HOH   A O   1 
HETATM 4986 O  O   . HOH   M 9 .   ? -14.939 -48.464 -18.592 1.00 36.78  ? 1288 HOH   A O   1 
HETATM 4987 O  O   . HOH   M 9 .   ? -15.522 -54.627 -43.869 1.00 46.13  ? 1289 HOH   A O   1 
HETATM 4988 O  O   . HOH   M 9 .   ? -11.812 -39.738 -39.418 1.00 56.27  ? 1290 HOH   A O   1 
HETATM 4989 O  O   . HOH   M 9 .   ? -22.495 -44.250 -33.190 0.48 32.87  ? 1291 HOH   A O   1 
HETATM 4990 O  O   . HOH   M 9 .   ? -0.281  -55.460 -32.856 1.00 57.84  ? 1292 HOH   A O   1 
HETATM 4991 O  O   . HOH   M 9 .   ? -24.295 -57.692 -46.671 1.00 49.52  ? 1293 HOH   A O   1 
HETATM 4992 O  O   . HOH   M 9 .   ? -2.956  -57.881 -24.430 1.00 26.27  ? 1294 HOH   A O   1 
HETATM 4993 O  O   . HOH   M 9 .   ? -6.281  -42.998 -20.849 1.00 52.51  ? 1295 HOH   A O   1 
HETATM 4994 O  O   . HOH   M 9 .   ? -26.619 -51.100 -1.906  1.00 40.02  ? 1296 HOH   A O   1 
HETATM 4995 O  O   . HOH   M 9 .   ? -35.711 -50.776 -22.551 1.00 58.66  ? 1297 HOH   A O   1 
HETATM 4996 O  O   . HOH   M 9 .   ? -12.489 -66.895 -29.618 1.00 36.47  ? 1298 HOH   A O   1 
HETATM 4997 O  O   . HOH   M 9 .   ? -33.754 -46.848 -15.549 1.00 57.86  ? 1299 HOH   A O   1 
HETATM 4998 O  O   . HOH   M 9 .   ? -20.060 -45.951 -25.284 1.00 42.13  ? 1300 HOH   A O   1 
HETATM 4999 O  O   . HOH   M 9 .   ? -10.178 -25.816 -12.161 1.00 56.10  ? 1301 HOH   A O   1 
HETATM 5000 O  O   . HOH   M 9 .   ? -27.229 -56.701 -39.516 1.00 50.91  ? 1302 HOH   A O   1 
HETATM 5001 O  O   . HOH   M 9 .   ? -37.345 -52.235 -12.772 1.00 28.84  ? 1303 HOH   A O   1 
HETATM 5002 O  O   . HOH   M 9 .   ? -10.202 -75.209 -9.171  1.00 65.25  ? 1304 HOH   A O   1 
HETATM 5003 O  O   . HOH   M 9 .   ? -30.053 -61.547 -33.469 1.00 57.09  ? 1305 HOH   A O   1 
HETATM 5004 O  O   . HOH   M 9 .   ? -11.738 -71.796 -15.570 1.00 24.82  ? 1306 HOH   A O   1 
HETATM 5005 O  O   . HOH   M 9 .   ? -9.041  -71.152 -14.805 0.46 32.97  ? 1307 HOH   A O   1 
HETATM 5006 O  O   . HOH   M 9 .   ? -30.493 -46.784 -24.827 0.48 38.78  ? 1308 HOH   A O   1 
HETATM 5007 O  O   . HOH   M 9 .   ? -34.710 -59.388 -29.042 1.00 56.79  ? 1309 HOH   A O   1 
HETATM 5008 O  O   . HOH   M 9 .   ? 13.613  -30.325 -19.809 1.00 52.08  ? 1310 HOH   A O   1 
HETATM 5009 O  O   . HOH   M 9 .   ? -35.734 -58.205 -27.285 1.00 52.39  ? 1311 HOH   A O   1 
HETATM 5010 O  O   . HOH   M 9 .   ? -37.610 -68.156 -12.431 1.00 46.70  ? 1312 HOH   A O   1 
HETATM 5011 O  O   . HOH   M 9 .   ? -31.501 -71.679 -13.621 1.00 54.90  ? 1313 HOH   A O   1 
HETATM 5012 O  O   . HOH   M 9 .   ? -3.777  -56.335 -7.161  1.00 34.52  ? 1314 HOH   A O   1 
HETATM 5013 O  O   . HOH   M 9 .   ? -34.079 -69.987 -18.551 1.00 36.89  ? 1315 HOH   A O   1 
HETATM 5014 O  O   . HOH   M 9 .   ? -35.408 -58.979 -0.537  1.00 47.99  ? 1316 HOH   A O   1 
HETATM 5015 O  O   . HOH   M 9 .   ? -23.133 -49.185 -41.998 1.00 41.37  ? 1317 HOH   A O   1 
HETATM 5016 O  O   . HOH   M 9 .   ? -2.436  -39.584 -45.879 1.00 45.96  ? 1318 HOH   A O   1 
HETATM 5017 O  O   . HOH   M 9 .   ? -7.889  -61.983 -33.535 1.00 50.81  ? 1319 HOH   A O   1 
HETATM 5018 O  O   . HOH   M 9 .   ? -5.363  -58.241 -30.168 1.00 37.43  ? 1320 HOH   A O   1 
HETATM 5019 O  O   . HOH   M 9 .   ? -24.347 -68.551 -38.239 1.00 51.90  ? 1321 HOH   A O   1 
HETATM 5020 O  O   . HOH   M 9 .   ? -0.879  -32.345 -25.432 1.00 30.40  ? 1322 HOH   A O   1 
HETATM 5021 O  O   . HOH   M 9 .   ? -20.127 -31.279 -26.538 1.00 32.45  ? 1323 HOH   A O   1 
HETATM 5022 O  O   . HOH   M 9 .   ? -4.116  -52.700 -38.589 1.00 67.46  ? 1324 HOH   A O   1 
HETATM 5023 O  O   . HOH   M 9 .   ? -7.684  -29.785 -46.193 1.00 42.40  ? 1325 HOH   A O   1 
HETATM 5024 O  O   . HOH   M 9 .   ? -3.674  -70.808 -9.028  1.00 39.41  ? 1326 HOH   A O   1 
HETATM 5025 O  O   . HOH   M 9 .   ? -18.231 -69.310 -24.805 1.00 36.77  ? 1327 HOH   A O   1 
HETATM 5026 O  O   . HOH   M 9 .   ? -5.888  -68.821 -7.246  1.00 35.52  ? 1328 HOH   A O   1 
HETATM 5027 O  O   . HOH   M 9 .   ? -27.060 -26.653 -35.759 1.00 35.39  ? 1329 HOH   A O   1 
HETATM 5028 O  O   . HOH   M 9 .   ? 3.554   -44.393 -40.023 1.00 58.24  ? 1330 HOH   A O   1 
HETATM 5029 O  O   . HOH   M 9 .   ? -1.059  -69.313 -16.361 0.46 31.84  ? 1331 HOH   A O   1 
HETATM 5030 O  O   . HOH   M 9 .   ? -7.437  -51.282 -10.418 1.00 57.80  ? 1332 HOH   A O   1 
HETATM 5031 O  O   . HOH   M 9 .   ? -2.419  -33.838 -13.535 1.00 56.47  ? 1333 HOH   A O   1 
HETATM 5032 O  O   . HOH   M 9 .   ? -22.582 -29.555 -14.319 1.00 64.25  ? 1334 HOH   A O   1 
HETATM 5033 O  O   . HOH   M 9 .   ? -26.419 -27.754 -42.583 1.00 51.31  ? 1335 HOH   A O   1 
HETATM 5034 O  O   . HOH   M 9 .   ? -18.776 -49.541 -34.676 1.00 56.42  ? 1336 HOH   A O   1 
HETATM 5035 O  O   . HOH   M 9 .   ? -32.106 -18.682 -31.137 1.00 47.63  ? 1337 HOH   A O   1 
HETATM 5036 O  O   . HOH   M 9 .   ? -17.893 -47.108 -14.931 1.00 38.86  ? 1338 HOH   A O   1 
HETATM 5037 O  O   . HOH   M 9 .   ? -17.592 -28.690 -41.227 1.00 60.04  ? 1339 HOH   A O   1 
HETATM 5038 O  O   . HOH   M 9 .   ? -26.670 -67.636 -27.939 1.00 26.50  ? 1340 HOH   A O   1 
HETATM 5039 O  O   . HOH   M 9 .   ? 9.880   -38.281 -39.360 1.00 50.80  ? 1341 HOH   A O   1 
HETATM 5040 O  O   . HOH   M 9 .   ? -14.891 -56.715 -41.892 1.00 30.90  ? 1342 HOH   A O   1 
HETATM 5041 O  O   . HOH   M 9 .   ? 1.025   -38.608 -21.019 1.00 52.04  ? 1343 HOH   A O   1 
HETATM 5042 O  O   . HOH   M 9 .   ? -23.481 -47.725 -33.679 1.00 51.37  ? 1344 HOH   A O   1 
HETATM 5043 O  O   . HOH   M 9 .   ? -19.239 -64.424 -2.948  1.00 46.32  ? 1345 HOH   A O   1 
HETATM 5044 O  O   . HOH   M 9 .   ? -4.424  -34.265 -14.603 1.00 53.33  ? 1346 HOH   A O   1 
HETATM 5045 O  O   . HOH   M 9 .   ? -12.637 -37.453 -22.291 1.00 54.21  ? 1347 HOH   A O   1 
HETATM 5046 O  O   . HOH   M 9 .   ? -10.981 -46.145 3.960   1.00 48.56  ? 1348 HOH   A O   1 
HETATM 5047 O  O   . HOH   M 9 .   ? 0.699   -31.287 -46.966 1.00 47.55  ? 1349 HOH   A O   1 
HETATM 5048 O  O   . HOH   M 9 .   ? 4.373   -62.355 -20.045 1.00 21.79  ? 1350 HOH   A O   1 
HETATM 5049 O  O   . HOH   M 9 .   ? -11.775 -40.801 -20.127 1.00 62.68  ? 1351 HOH   A O   1 
HETATM 5050 O  O   . HOH   M 9 .   ? -7.063  -57.507 -0.987  1.00 47.49  ? 1352 HOH   A O   1 
HETATM 5051 O  O   . HOH   M 9 .   ? -12.278 -43.888 -16.398 1.00 48.33  ? 1353 HOH   A O   1 
HETATM 5052 O  O   . HOH   M 9 .   ? -27.176 -73.581 -5.057  1.00 47.60  ? 1354 HOH   A O   1 
HETATM 5053 O  O   . HOH   M 9 .   ? -21.013 -43.557 -41.775 1.00 60.83  ? 1355 HOH   A O   1 
HETATM 5054 O  O   . HOH   M 9 .   ? -35.264 -67.545 -5.581  1.00 55.00  ? 1356 HOH   A O   1 
HETATM 5055 O  O   . HOH   M 9 .   ? -8.629  -30.869 -14.996 1.00 52.40  ? 1357 HOH   A O   1 
HETATM 5056 O  O   . HOH   M 9 .   ? -13.119 -32.576 -20.431 1.00 32.43  ? 1358 HOH   A O   1 
HETATM 5057 O  O   . HOH   M 9 .   ? -13.286 -11.115 -32.246 1.00 54.46  ? 1359 HOH   A O   1 
HETATM 5058 O  O   . HOH   M 9 .   ? -16.257 -49.003 -16.209 1.00 26.94  ? 1360 HOH   A O   1 
HETATM 5059 O  O   . HOH   M 9 .   ? -9.012  -35.484 -44.811 1.00 56.58  ? 1361 HOH   A O   1 
HETATM 5060 O  O   . HOH   M 9 .   ? 2.784   -64.399 -20.632 1.00 18.75  ? 1362 HOH   A O   1 
HETATM 5061 O  O   . HOH   M 9 .   ? -3.651  -50.315 -16.890 1.00 50.68  ? 1363 HOH   A O   1 
HETATM 5062 O  O   . HOH   M 9 .   ? -29.777 -59.357 -19.787 1.00 31.26  ? 1364 HOH   A O   1 
HETATM 5063 O  O   . HOH   M 9 .   ? 0.000   -58.020 -16.471 0.50 42.60  ? 1365 HOH   A O   1 
HETATM 5064 O  O   . HOH   M 9 .   ? -25.367 -23.443 -41.917 1.00 59.46  ? 1366 HOH   A O   1 
HETATM 5065 O  O   . HOH   M 9 .   ? 0.509   -45.237 -36.719 1.00 49.36  ? 1367 HOH   A O   1 
HETATM 5066 O  O   . HOH   M 9 .   ? -40.585 -62.319 -3.317  1.00 52.21  ? 1368 HOH   A O   1 
HETATM 5067 O  O   . HOH   M 9 .   ? -9.267  -23.752 -3.800  1.00 64.62  ? 1369 HOH   A O   1 
HETATM 5068 O  O   . HOH   M 9 .   ? -3.019  -55.494 -28.828 1.00 33.43  ? 1370 HOH   A O   1 
HETATM 5069 O  O   . HOH   M 9 .   ? 0.025   -45.637 -43.099 1.00 56.95  ? 1371 HOH   A O   1 
HETATM 5070 O  O   . HOH   M 9 .   ? -23.084 -37.053 -32.820 1.00 53.06  ? 1372 HOH   A O   1 
HETATM 5071 O  O   . HOH   M 9 .   ? -10.781 -68.124 -38.559 1.00 58.96  ? 1373 HOH   A O   1 
HETATM 5072 O  O   . HOH   M 9 .   ? -10.325 -17.396 -40.553 1.00 51.96  ? 1374 HOH   A O   1 
HETATM 5073 O  O   . HOH   M 9 .   ? -17.235 -71.281 -22.267 0.46 31.26  ? 1375 HOH   A O   1 
HETATM 5074 O  O   . HOH   M 9 .   ? 11.437  -37.340 -18.815 1.00 42.58  ? 1376 HOH   A O   1 
HETATM 5075 O  O   . HOH   M 9 .   ? -7.193  -29.777 -13.207 1.00 53.32  ? 1377 HOH   A O   1 
HETATM 5076 O  O   . HOH   M 9 .   ? -2.828  -51.795 -15.306 1.00 49.87  ? 1378 HOH   A O   1 
HETATM 5077 O  O   . HOH   M 9 .   ? -4.766  -47.295 -21.527 1.00 32.33  ? 1379 HOH   A O   1 
HETATM 5078 O  O   . HOH   M 9 .   ? -37.682 -55.038 -25.037 1.00 65.20  ? 1380 HOH   A O   1 
HETATM 5079 O  O   . HOH   M 9 .   ? -8.440  -67.857 -28.719 1.00 60.35  ? 1381 HOH   A O   1 
HETATM 5080 O  O   . HOH   M 9 .   ? -14.387 -44.580 -10.165 1.00 63.83  ? 1382 HOH   A O   1 
HETATM 5081 O  O   . HOH   M 9 .   ? -15.186 -45.365 -19.366 1.00 56.51  ? 1383 HOH   A O   1 
HETATM 5082 O  O   . HOH   M 9 .   ? -10.082 -38.188 -43.528 1.00 55.93  ? 1384 HOH   A O   1 
HETATM 5083 O  O   . HOH   M 9 .   ? -17.606 -28.063 -44.742 1.00 51.99  ? 1385 HOH   A O   1 
HETATM 5084 O  O   . HOH   M 9 .   ? -22.628 -37.382 -37.503 1.00 60.55  ? 1386 HOH   A O   1 
HETATM 5085 O  O   . HOH   M 9 .   ? -3.159  -52.184 -4.851  1.00 66.31  ? 1387 HOH   A O   1 
HETATM 5086 O  O   . HOH   M 9 .   ? -10.721 -33.809 -44.329 1.00 62.54  ? 1388 HOH   A O   1 
HETATM 5087 O  O   . HOH   M 9 .   ? -37.010 -64.546 0.082   1.00 45.35  ? 1389 HOH   A O   1 
HETATM 5088 O  O   . HOH   M 9 .   ? -34.196 -70.425 -14.165 1.00 61.01  ? 1390 HOH   A O   1 
HETATM 5089 O  O   . HOH   M 9 .   ? -42.402 -66.281 -10.297 1.00 53.75  ? 1391 HOH   A O   1 
HETATM 5090 O  O   . HOH   M 9 .   ? 0.000   -58.020 -28.760 0.50 31.99  ? 1392 HOH   A O   1 
HETATM 5091 O  O   . HOH   M 9 .   ? -25.576 -2.231  -28.855 1.00 60.36  ? 1393 HOH   A O   1 
HETATM 5092 O  O   . HOH   M 9 .   ? -37.993 -51.929 -4.006  1.00 46.20  ? 1394 HOH   A O   1 
HETATM 5093 O  O   . HOH   M 9 .   ? -29.415 -69.025 -39.641 1.00 66.49  ? 1395 HOH   A O   1 
HETATM 5094 O  O   . HOH   M 9 .   ? -19.649 -57.997 -48.370 1.00 68.83  ? 1396 HOH   A O   1 
HETATM 5095 O  O   . HOH   M 9 .   ? 0.125   -42.297 -21.791 0.46 29.83  ? 1397 HOH   A O   1 
HETATM 5096 O  O   . HOH   M 9 .   ? -6.904  -74.303 -13.286 0.46 45.48  ? 1398 HOH   A O   1 
HETATM 5097 O  O   . HOH   M 9 .   ? -15.836 -69.015 -5.984  1.00 27.60  ? 1399 HOH   A O   1 
HETATM 5098 O  O   . HOH   M 9 .   ? -15.621 -41.431 -38.610 1.00 38.73  ? 1400 HOH   A O   1 
HETATM 5099 O  O   . HOH   M 9 .   ? -36.398 -56.382 -4.206  1.00 44.69  ? 1401 HOH   A O   1 
HETATM 5100 O  O   . HOH   M 9 .   ? -4.338  -49.136 2.793   1.00 65.60  ? 1402 HOH   A O   1 
HETATM 5101 O  O   . HOH   M 9 .   ? -5.063  -66.505 -6.163  1.00 61.63  ? 1403 HOH   A O   1 
HETATM 5102 O  O   . HOH   M 9 .   ? -5.144  -64.717 -31.198 1.00 52.11  ? 1404 HOH   A O   1 
HETATM 5103 O  O   . HOH   M 9 .   ? -41.246 -56.733 -13.705 1.00 32.03  ? 1405 HOH   A O   1 
HETATM 5104 O  O   . HOH   M 9 .   ? -31.512 -18.430 -5.843  1.00 59.80  ? 1406 HOH   A O   1 
HETATM 5105 O  O   . HOH   M 9 .   ? -15.177 -69.693 -20.048 0.46 38.38  ? 1407 HOH   A O   1 
HETATM 5106 O  O   . HOH   M 9 .   ? 0.423   -62.215 -17.583 1.00 42.07  ? 1408 HOH   A O   1 
HETATM 5107 O  O   . HOH   M 9 .   ? -16.686 -39.092 -39.805 1.00 49.18  ? 1409 HOH   A O   1 
HETATM 5108 O  O   . HOH   M 9 .   ? -6.351  -44.715 -17.331 1.00 61.85  ? 1410 HOH   A O   1 
HETATM 5109 O  O   . HOH   M 9 .   ? -10.563 -67.364 -36.044 1.00 68.99  ? 1411 HOH   A O   1 
HETATM 5110 O  O   . HOH   M 9 .   ? -34.381 -49.247 -10.138 1.00 41.36  ? 1412 HOH   A O   1 
HETATM 5111 O  O   . HOH   M 9 .   ? -18.816 -13.704 -39.035 1.00 66.68  ? 1413 HOH   A O   1 
HETATM 5112 O  O   . HOH   M 9 .   ? -24.932 -28.215 -22.381 1.00 48.99  ? 1414 HOH   A O   1 
HETATM 5113 O  O   . HOH   M 9 .   ? -3.039  -60.462 -5.994  1.00 62.70  ? 1415 HOH   A O   1 
HETATM 5114 O  O   . HOH   M 9 .   ? -2.758  -56.296 -33.701 1.00 57.41  ? 1416 HOH   A O   1 
HETATM 5115 O  O   . HOH   M 9 .   ? -35.699 -47.827 -13.929 1.00 57.78  ? 1417 HOH   A O   1 
HETATM 5116 O  O   . HOH   M 9 .   ? -1.095  -62.867 -15.164 1.00 50.54  ? 1418 HOH   A O   1 
HETATM 5117 O  O   . HOH   M 9 .   ? -18.289 -67.678 -6.395  1.00 25.21  ? 1419 HOH   A O   1 
HETATM 5118 O  O   . HOH   M 9 .   ? -10.051 -65.034 -42.352 1.00 55.39  ? 1420 HOH   A O   1 
HETATM 5119 O  O   . HOH   M 9 .   ? -12.023 -36.266 -42.868 1.00 51.58  ? 1421 HOH   A O   1 
HETATM 5120 O  O   . HOH   M 9 .   ? 16.611  -34.206 -26.469 1.00 59.14  ? 1422 HOH   A O   1 
HETATM 5121 O  O   . HOH   M 9 .   ? -19.891 -68.005 -4.336  1.00 30.98  ? 1423 HOH   A O   1 
HETATM 5122 O  O   . HOH   M 9 .   ? -2.820  -59.420 -0.476  1.00 47.25  ? 1424 HOH   A O   1 
HETATM 5123 O  O   . HOH   M 9 .   ? -26.243 -20.866 -4.732  1.00 54.62  ? 1425 HOH   A O   1 
HETATM 5124 O  O   . HOH   M 9 .   ? -5.454  -63.927 -6.550  1.00 47.60  ? 1426 HOH   A O   1 
HETATM 5125 O  O   . HOH   M 9 .   ? -4.151  -60.522 -10.193 1.00 54.02  ? 1427 HOH   A O   1 
HETATM 5126 O  O   . HOH   M 9 .   ? -25.457 -43.389 -33.948 1.00 66.41  ? 1428 HOH   A O   1 
HETATM 5127 O  O   . HOH   M 9 .   ? 10.348  -20.125 -25.347 1.00 54.59  ? 1429 HOH   A O   1 
HETATM 5128 O  O   . HOH   M 9 .   ? -44.158 -67.966 -15.804 1.00 66.62  ? 1430 HOH   A O   1 
HETATM 5129 O  O   . HOH   M 9 .   ? 13.441  -25.357 -26.063 1.00 67.23  ? 1431 HOH   A O   1 
HETATM 5130 O  O   . HOH   M 9 .   ? -28.093 -55.364 -45.342 1.00 58.24  ? 1432 HOH   A O   1 
HETATM 5131 O  O   . HOH   M 9 .   ? -7.714  -63.461 -40.908 1.00 71.88  ? 1433 HOH   A O   1 
HETATM 5132 O  O   . HOH   M 9 .   ? -4.100  -62.589 -8.444  1.00 57.06  ? 1434 HOH   A O   1 
HETATM 5133 O  O   . HOH   M 9 .   ? -42.710 -61.188 -1.665  1.00 58.65  ? 1435 HOH   A O   1 
# 
