data_7I2J
# 
_entry.id   7I2J 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   7I2J         pdb_00007i2j 10.2210/pdb7i2j/pdb 
WWPDB D_1001408234 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-02 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.entry_id                        7I2J 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.recvd_initial_deposition_date   2025-03-06 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.SG_entry                        ? 
_pdbx_database_status.pdb_format_compatible           Y 
_pdbx_database_status.methods_development_category    ? 
# 
_pdbx_contact_author.id                 1 
_pdbx_contact_author.email              fr193@cabm.rutgers.edu 
_pdbx_contact_author.name_first         'Francesc Xavier' 
_pdbx_contact_author.name_last          Ruiz 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0457-0030 
_pdbx_contact_author.name_mi            ? 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Aschenbrenner, J.C.' 1  ? 
'Saini, M.'           2  ? 
'Chopra, A.'          3  ? 
'Marples, P.G.'       4  ? 
'Balcomb, B.H.'       5  ? 
'Lithgo, R.M.'        6  ? 
'Fearon, D.'          7  ? 
'von Delft, F.'       8  ? 
'Ruiz, F.X.'          9  ? 
'Arnold, E.'          10 ? 
# 
_citation.id                        primary 
_citation.title                     
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_volume            ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.year                      ? 
_citation.journal_id_ASTM           ? 
_citation.country                   ? 
_citation.journal_id_ISSN           ? 
_citation.journal_id_CSD            0353 
_citation.book_publisher            ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_DOI      ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.identifier_ORCID 
_citation_author.ordinal 
primary 'Aschenbrenner, J.C.' ? 1  
primary 'Saini, M.'           ? 2  
primary 'Chopra, A.'          ? 3  
primary 'Marples, P.G.'       ? 4  
primary 'Balcomb, B.H.'       ? 5  
primary 'Lithgo, R.M.'        ? 6  
primary 'Fearon, D.'          ? 7  
primary 'von Delft, F.'       ? 8  
primary 'Ruiz, F.X.'          ? 9  
primary 'Arnold, E.'          ? 10 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'NS5 RNA-dependent RNA polymerase'                         73890.008 1   ? ? ? ? 
2 non-polymer syn 'ZINC ION'                                                 65.409    2   ? ? ? ? 
3 non-polymer syn '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                     195.237   1   ? ? ? ? 
4 non-polymer syn 'DIMETHYL SULFOXIDE'                                       78.133    3   ? ? ? ? 
5 non-polymer syn 'PHOSPHATE ION'                                            94.971    2   ? ? ? ? 
6 non-polymer syn 'DI(HYDROXYETHYL)ETHER'                                    106.120   1   ? ? ? ? 
7 non-polymer syn '4-[(furan-2-yl)methyl]-1lambda~6~,4-thiazinane-1,1-dione' 215.269   1   ? ? ? ? 
8 non-polymer syn 'CHLORIDE ION'                                             35.453    1   ? ? ? ? 
9 water       nat water                                                      18.015    393 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION'                                                 ZN  
3 '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                     MES 
4 'DIMETHYL SULFOXIDE'                                       DMS 
5 'PHOSPHATE ION'                                            PO4 
6 'DI(HYDROXYETHYL)ETHER'                                    PEG 
7 '4-[(furan-2-yl)methyl]-1lambda~6~,4-thiazinane-1,1-dione' O3D 
8 'CHLORIDE ION'                                             CL  
9 water                                                      HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PRO n 
1 3   GLY n 
1 4   ILE n 
1 5   GLU n 
1 6   SER n 
1 7   GLU n 
1 8   THR n 
1 9   PRO n 
1 10  ASN n 
1 11  LEU n 
1 12  ASP n 
1 13  ILE n 
1 14  ILE n 
1 15  GLY n 
1 16  LYS n 
1 17  ARG n 
1 18  ILE n 
1 19  GLU n 
1 20  LYS n 
1 21  ILE n 
1 22  LYS n 
1 23  GLN n 
1 24  GLU n 
1 25  HIS n 
1 26  GLU n 
1 27  THR n 
1 28  SER n 
1 29  TRP n 
1 30  HIS n 
1 31  TYR n 
1 32  ASP n 
1 33  GLN n 
1 34  ASP n 
1 35  HIS n 
1 36  PRO n 
1 37  TYR n 
1 38  LYS n 
1 39  THR n 
1 40  TRP n 
1 41  ALA n 
1 42  TYR n 
1 43  HIS n 
1 44  GLY n 
1 45  SER n 
1 46  TYR n 
1 47  GLU n 
1 48  THR n 
1 49  LYS n 
1 50  GLN n 
1 51  THR n 
1 52  GLY n 
1 53  SER n 
1 54  ALA n 
1 55  SER n 
1 56  SER n 
1 57  MET n 
1 58  VAL n 
1 59  ASN n 
1 60  GLY n 
1 61  VAL n 
1 62  VAL n 
1 63  ARG n 
1 64  LEU n 
1 65  LEU n 
1 66  THR n 
1 67  LYS n 
1 68  PRO n 
1 69  TRP n 
1 70  ASP n 
1 71  ILE n 
1 72  ILE n 
1 73  PRO n 
1 74  MET n 
1 75  VAL n 
1 76  THR n 
1 77  GLN n 
1 78  MET n 
1 79  ALA n 
1 80  MET n 
1 81  THR n 
1 82  ASP n 
1 83  THR n 
1 84  THR n 
1 85  PRO n 
1 86  PHE n 
1 87  GLY n 
1 88  GLN n 
1 89  GLN n 
1 90  ARG n 
1 91  VAL n 
1 92  PHE n 
1 93  LYS n 
1 94  GLU n 
1 95  LYS n 
1 96  VAL n 
1 97  ASP n 
1 98  THR n 
1 99  ARG n 
1 100 THR n 
1 101 GLN n 
1 102 GLU n 
1 103 PRO n 
1 104 LYS n 
1 105 GLU n 
1 106 GLY n 
1 107 THR n 
1 108 LYS n 
1 109 LYS n 
1 110 LEU n 
1 111 MET n 
1 112 LYS n 
1 113 ILE n 
1 114 THR n 
1 115 ALA n 
1 116 GLU n 
1 117 TRP n 
1 118 LEU n 
1 119 TRP n 
1 120 LYS n 
1 121 GLU n 
1 122 LEU n 
1 123 GLY n 
1 124 LYS n 
1 125 LYS n 
1 126 LYS n 
1 127 THR n 
1 128 PRO n 
1 129 ARG n 
1 130 MET n 
1 131 CYS n 
1 132 THR n 
1 133 ARG n 
1 134 GLU n 
1 135 GLU n 
1 136 PHE n 
1 137 THR n 
1 138 ARG n 
1 139 LYS n 
1 140 VAL n 
1 141 ARG n 
1 142 SER n 
1 143 ASN n 
1 144 ALA n 
1 145 ALA n 
1 146 LEU n 
1 147 GLY n 
1 148 ALA n 
1 149 ILE n 
1 150 PHE n 
1 151 THR n 
1 152 ASP n 
1 153 GLU n 
1 154 ASN n 
1 155 LYS n 
1 156 TRP n 
1 157 LYS n 
1 158 SER n 
1 159 ALA n 
1 160 ARG n 
1 161 GLU n 
1 162 ALA n 
1 163 VAL n 
1 164 GLU n 
1 165 ASP n 
1 166 SER n 
1 167 GLY n 
1 168 PHE n 
1 169 TRP n 
1 170 GLU n 
1 171 LEU n 
1 172 VAL n 
1 173 ASP n 
1 174 LYS n 
1 175 GLU n 
1 176 ARG n 
1 177 ASN n 
1 178 LEU n 
1 179 HIS n 
1 180 LEU n 
1 181 GLU n 
1 182 GLY n 
1 183 LYS n 
1 184 CYS n 
1 185 GLU n 
1 186 THR n 
1 187 CYS n 
1 188 VAL n 
1 189 TYR n 
1 190 ASN n 
1 191 MET n 
1 192 MET n 
1 193 GLY n 
1 194 LYS n 
1 195 ARG n 
1 196 GLU n 
1 197 LYS n 
1 198 LYS n 
1 199 LEU n 
1 200 GLY n 
1 201 GLU n 
1 202 PHE n 
1 203 GLY n 
1 204 LYS n 
1 205 ALA n 
1 206 LYS n 
1 207 GLY n 
1 208 SER n 
1 209 ARG n 
1 210 ALA n 
1 211 ILE n 
1 212 TRP n 
1 213 TYR n 
1 214 MET n 
1 215 TRP n 
1 216 LEU n 
1 217 GLY n 
1 218 ALA n 
1 219 ARG n 
1 220 PHE n 
1 221 LEU n 
1 222 GLU n 
1 223 PHE n 
1 224 GLU n 
1 225 ALA n 
1 226 LEU n 
1 227 GLY n 
1 228 PHE n 
1 229 LEU n 
1 230 ASN n 
1 231 GLU n 
1 232 ASP n 
1 233 HIS n 
1 234 TRP n 
1 235 PHE n 
1 236 SER n 
1 237 ARG n 
1 238 GLU n 
1 239 ASN n 
1 240 SER n 
1 241 LEU n 
1 242 SER n 
1 243 GLY n 
1 244 VAL n 
1 245 GLU n 
1 246 GLY n 
1 247 GLU n 
1 248 GLY n 
1 249 LEU n 
1 250 HIS n 
1 251 LYS n 
1 252 LEU n 
1 253 GLY n 
1 254 TYR n 
1 255 ILE n 
1 256 LEU n 
1 257 ARG n 
1 258 ASP n 
1 259 VAL n 
1 260 SER n 
1 261 LYS n 
1 262 LYS n 
1 263 GLU n 
1 264 GLY n 
1 265 GLY n 
1 266 ALA n 
1 267 MET n 
1 268 TYR n 
1 269 ALA n 
1 270 ASP n 
1 271 ASP n 
1 272 THR n 
1 273 ALA n 
1 274 GLY n 
1 275 TRP n 
1 276 ASP n 
1 277 THR n 
1 278 ARG n 
1 279 ILE n 
1 280 THR n 
1 281 LEU n 
1 282 GLU n 
1 283 ASP n 
1 284 LEU n 
1 285 LYS n 
1 286 ASN n 
1 287 GLU n 
1 288 GLU n 
1 289 MET n 
1 290 VAL n 
1 291 THR n 
1 292 ASN n 
1 293 HIS n 
1 294 MET n 
1 295 GLU n 
1 296 GLY n 
1 297 GLU n 
1 298 HIS n 
1 299 LYS n 
1 300 LYS n 
1 301 LEU n 
1 302 ALA n 
1 303 GLU n 
1 304 ALA n 
1 305 ILE n 
1 306 PHE n 
1 307 LYS n 
1 308 LEU n 
1 309 THR n 
1 310 TYR n 
1 311 GLN n 
1 312 ASN n 
1 313 LYS n 
1 314 VAL n 
1 315 VAL n 
1 316 ARG n 
1 317 VAL n 
1 318 GLN n 
1 319 ARG n 
1 320 PRO n 
1 321 THR n 
1 322 PRO n 
1 323 ARG n 
1 324 GLY n 
1 325 THR n 
1 326 VAL n 
1 327 MET n 
1 328 ASP n 
1 329 ILE n 
1 330 ILE n 
1 331 SER n 
1 332 ARG n 
1 333 ARG n 
1 334 ASP n 
1 335 GLN n 
1 336 ARG n 
1 337 GLY n 
1 338 SER n 
1 339 GLY n 
1 340 GLN n 
1 341 VAL n 
1 342 VAL n 
1 343 THR n 
1 344 TYR n 
1 345 GLY n 
1 346 LEU n 
1 347 ASN n 
1 348 THR n 
1 349 PHE n 
1 350 THR n 
1 351 ASN n 
1 352 MET n 
1 353 GLU n 
1 354 ALA n 
1 355 GLN n 
1 356 LEU n 
1 357 ILE n 
1 358 ARG n 
1 359 GLN n 
1 360 MET n 
1 361 GLU n 
1 362 GLY n 
1 363 GLU n 
1 364 GLY n 
1 365 VAL n 
1 366 PHE n 
1 367 LYS n 
1 368 SER n 
1 369 ILE n 
1 370 GLN n 
1 371 HIS n 
1 372 LEU n 
1 373 THR n 
1 374 VAL n 
1 375 THR n 
1 376 GLU n 
1 377 GLU n 
1 378 ILE n 
1 379 ALA n 
1 380 VAL n 
1 381 LYS n 
1 382 ASN n 
1 383 TRP n 
1 384 LEU n 
1 385 VAL n 
1 386 ARG n 
1 387 VAL n 
1 388 GLY n 
1 389 ARG n 
1 390 GLU n 
1 391 ARG n 
1 392 LEU n 
1 393 SER n 
1 394 ARG n 
1 395 MET n 
1 396 ALA n 
1 397 ILE n 
1 398 SER n 
1 399 GLY n 
1 400 ASP n 
1 401 ASP n 
1 402 CYS n 
1 403 VAL n 
1 404 VAL n 
1 405 LYS n 
1 406 PRO n 
1 407 LEU n 
1 408 ASP n 
1 409 ASP n 
1 410 ARG n 
1 411 PHE n 
1 412 ALA n 
1 413 SER n 
1 414 ALA n 
1 415 LEU n 
1 416 THR n 
1 417 ALA n 
1 418 LEU n 
1 419 ASN n 
1 420 ASP n 
1 421 MET n 
1 422 GLY n 
1 423 LYS n 
1 424 VAL n 
1 425 ARG n 
1 426 LYS n 
1 427 ASP n 
1 428 ILE n 
1 429 GLN n 
1 430 GLN n 
1 431 TRP n 
1 432 GLU n 
1 433 PRO n 
1 434 SER n 
1 435 ARG n 
1 436 GLY n 
1 437 TRP n 
1 438 ASN n 
1 439 ASP n 
1 440 TRP n 
1 441 THR n 
1 442 GLN n 
1 443 VAL n 
1 444 PRO n 
1 445 PHE n 
1 446 CYS n 
1 447 SER n 
1 448 HIS n 
1 449 HIS n 
1 450 PHE n 
1 451 HIS n 
1 452 GLU n 
1 453 LEU n 
1 454 ILE n 
1 455 MET n 
1 456 LYS n 
1 457 ASP n 
1 458 GLY n 
1 459 ARG n 
1 460 VAL n 
1 461 LEU n 
1 462 VAL n 
1 463 VAL n 
1 464 PRO n 
1 465 CYS n 
1 466 ARG n 
1 467 ASN n 
1 468 GLN n 
1 469 ASP n 
1 470 GLU n 
1 471 LEU n 
1 472 ILE n 
1 473 GLY n 
1 474 ARG n 
1 475 ALA n 
1 476 ARG n 
1 477 ILE n 
1 478 SER n 
1 479 GLN n 
1 480 GLY n 
1 481 ALA n 
1 482 GLY n 
1 483 TRP n 
1 484 SER n 
1 485 LEU n 
1 486 ARG n 
1 487 GLU n 
1 488 THR n 
1 489 ALA n 
1 490 CYS n 
1 491 LEU n 
1 492 GLY n 
1 493 LYS n 
1 494 SER n 
1 495 TYR n 
1 496 ALA n 
1 497 GLN n 
1 498 MET n 
1 499 TRP n 
1 500 SER n 
1 501 LEU n 
1 502 MET n 
1 503 TYR n 
1 504 PHE n 
1 505 HIS n 
1 506 ARG n 
1 507 ARG n 
1 508 ASP n 
1 509 LEU n 
1 510 ARG n 
1 511 LEU n 
1 512 ALA n 
1 513 ALA n 
1 514 ASN n 
1 515 ALA n 
1 516 ILE n 
1 517 CYS n 
1 518 SER n 
1 519 ALA n 
1 520 VAL n 
1 521 PRO n 
1 522 SER n 
1 523 HIS n 
1 524 TRP n 
1 525 VAL n 
1 526 PRO n 
1 527 THR n 
1 528 SER n 
1 529 ARG n 
1 530 THR n 
1 531 THR n 
1 532 TRP n 
1 533 SER n 
1 534 ILE n 
1 535 HIS n 
1 536 ALA n 
1 537 THR n 
1 538 HIS n 
1 539 GLU n 
1 540 TRP n 
1 541 MET n 
1 542 THR n 
1 543 THR n 
1 544 GLU n 
1 545 ASP n 
1 546 MET n 
1 547 LEU n 
1 548 THR n 
1 549 VAL n 
1 550 TRP n 
1 551 ASN n 
1 552 ARG n 
1 553 VAL n 
1 554 TRP n 
1 555 ILE n 
1 556 GLN n 
1 557 GLU n 
1 558 ASN n 
1 559 PRO n 
1 560 TRP n 
1 561 MET n 
1 562 GLU n 
1 563 ASP n 
1 564 LYS n 
1 565 THR n 
1 566 PRO n 
1 567 VAL n 
1 568 GLU n 
1 569 SER n 
1 570 TRP n 
1 571 GLU n 
1 572 GLU n 
1 573 ILE n 
1 574 PRO n 
1 575 TYR n 
1 576 LEU n 
1 577 GLY n 
1 578 LYS n 
1 579 ARG n 
1 580 GLU n 
1 581 ASP n 
1 582 GLN n 
1 583 TRP n 
1 584 CYS n 
1 585 GLY n 
1 586 SER n 
1 587 LEU n 
1 588 ILE n 
1 589 GLY n 
1 590 LEU n 
1 591 THR n 
1 592 SER n 
1 593 ARG n 
1 594 ALA n 
1 595 THR n 
1 596 TRP n 
1 597 ALA n 
1 598 LYS n 
1 599 ASN n 
1 600 ILE n 
1 601 GLN n 
1 602 THR n 
1 603 ALA n 
1 604 ILE n 
1 605 ASN n 
1 606 GLN n 
1 607 VAL n 
1 608 ARG n 
1 609 SER n 
1 610 LEU n 
1 611 ILE n 
1 612 GLY n 
1 613 ASN n 
1 614 GLU n 
1 615 GLU n 
1 616 TYR n 
1 617 THR n 
1 618 ASP n 
1 619 TYR n 
1 620 MET n 
1 621 PRO n 
1 622 SER n 
1 623 MET n 
1 624 LYS n 
1 625 ARG n 
1 626 PHE n 
1 627 ARG n 
1 628 ARG n 
1 629 GLU n 
1 630 GLU n 
1 631 GLU n 
1 632 GLU n 
1 633 ALA n 
1 634 GLY n 
1 635 VAL n 
1 636 LEU n 
1 637 TRP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   637 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'dengue virus type 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     11060 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                                    ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                                   ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                                 ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                            ? 'C4 H7 N O4'     133.103 
CL  non-polymer         . 'CHLORIDE ION'                                             ? 'Cl -1'          35.453  
CYS 'L-peptide linking' y CYSTEINE                                                   ? 'C3 H7 N O2 S'   121.158 
DMS non-polymer         . 'DIMETHYL SULFOXIDE'                                       ? 'C2 H6 O S'      78.133  
GLN 'L-peptide linking' y GLUTAMINE                                                  ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                            ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                                    ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                                  ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                                      ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                                 ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                                    ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                                     ? 'C6 H15 N2 O2 1' 147.195 
MES non-polymer         . '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                     ? 'C6 H13 N O4 S'  195.237 
MET 'L-peptide linking' y METHIONINE                                                 ? 'C5 H11 N O2 S'  149.211 
O3D non-polymer         . '4-[(furan-2-yl)methyl]-1lambda~6~,4-thiazinane-1,1-dione' ? 'C9 H13 N O3 S'  215.269 
PEG non-polymer         . 'DI(HYDROXYETHYL)ETHER'                                    ? 'C4 H10 O3'      106.120 
PHE 'L-peptide linking' y PHENYLALANINE                                              ? 'C9 H11 N O2'    165.189 
PO4 non-polymer         . 'PHOSPHATE ION'                                            ? 'O4 P -3'        94.971  
PRO 'L-peptide linking' y PROLINE                                                    ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                                     ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                                  ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                                 ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                                   ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                                                     ? 'C5 H11 N O2'    117.146 
ZN  non-polymer         . 'ZINC ION'                                                 ? 'Zn 2'           65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   264 ?   ?   ?   A . n 
A 1 2   PRO 2   265 ?   ?   ?   A . n 
A 1 3   GLY 3   266 ?   ?   ?   A . n 
A 1 4   ILE 4   267 ?   ?   ?   A . n 
A 1 5   GLU 5   268 ?   ?   ?   A . n 
A 1 6   SER 6   269 ?   ?   ?   A . n 
A 1 7   GLU 7   270 ?   ?   ?   A . n 
A 1 8   THR 8   271 ?   ?   ?   A . n 
A 1 9   PRO 9   272 ?   ?   ?   A . n 
A 1 10  ASN 10  273 273 ASN ASN A . n 
A 1 11  LEU 11  274 274 LEU LEU A . n 
A 1 12  ASP 12  275 275 ASP ASP A . n 
A 1 13  ILE 13  276 276 ILE ILE A . n 
A 1 14  ILE 14  277 277 ILE ILE A . n 
A 1 15  GLY 15  278 278 GLY GLY A . n 
A 1 16  LYS 16  279 279 LYS LYS A . n 
A 1 17  ARG 17  280 280 ARG ARG A . n 
A 1 18  ILE 18  281 281 ILE ILE A . n 
A 1 19  GLU 19  282 282 GLU GLU A . n 
A 1 20  LYS 20  283 283 LYS LYS A . n 
A 1 21  ILE 21  284 284 ILE ILE A . n 
A 1 22  LYS 22  285 285 LYS LYS A . n 
A 1 23  GLN 23  286 286 GLN GLN A . n 
A 1 24  GLU 24  287 287 GLU GLU A . n 
A 1 25  HIS 25  288 288 HIS HIS A . n 
A 1 26  GLU 26  289 289 GLU GLU A . n 
A 1 27  THR 27  290 290 THR THR A . n 
A 1 28  SER 28  291 291 SER SER A . n 
A 1 29  TRP 29  292 292 TRP TRP A . n 
A 1 30  HIS 30  293 293 HIS HIS A . n 
A 1 31  TYR 31  294 294 TYR TYR A . n 
A 1 32  ASP 32  295 295 ASP ASP A . n 
A 1 33  GLN 33  296 296 GLN GLN A . n 
A 1 34  ASP 34  297 297 ASP ASP A . n 
A 1 35  HIS 35  298 298 HIS HIS A . n 
A 1 36  PRO 36  299 299 PRO PRO A . n 
A 1 37  TYR 37  300 300 TYR TYR A . n 
A 1 38  LYS 38  301 301 LYS LYS A . n 
A 1 39  THR 39  302 302 THR THR A . n 
A 1 40  TRP 40  303 303 TRP TRP A . n 
A 1 41  ALA 41  304 304 ALA ALA A . n 
A 1 42  TYR 42  305 305 TYR TYR A . n 
A 1 43  HIS 43  306 306 HIS HIS A . n 
A 1 44  GLY 44  307 307 GLY GLY A . n 
A 1 45  SER 45  308 308 SER SER A . n 
A 1 46  TYR 46  309 309 TYR TYR A . n 
A 1 47  GLU 47  310 310 GLU GLU A . n 
A 1 48  THR 48  311 311 THR THR A . n 
A 1 49  LYS 49  312 312 LYS LYS A . n 
A 1 50  GLN 50  313 ?   ?   ?   A . n 
A 1 51  THR 51  314 ?   ?   ?   A . n 
A 1 52  GLY 52  315 ?   ?   ?   A . n 
A 1 53  SER 53  316 ?   ?   ?   A . n 
A 1 54  ALA 54  317 ?   ?   ?   A . n 
A 1 55  SER 55  318 318 SER SER A . n 
A 1 56  SER 56  319 319 SER SER A . n 
A 1 57  MET 57  320 320 MET MET A . n 
A 1 58  VAL 58  321 321 VAL VAL A . n 
A 1 59  ASN 59  322 322 ASN ASN A . n 
A 1 60  GLY 60  323 323 GLY GLY A . n 
A 1 61  VAL 61  324 324 VAL VAL A . n 
A 1 62  VAL 62  325 325 VAL VAL A . n 
A 1 63  ARG 63  326 326 ARG ARG A . n 
A 1 64  LEU 64  327 327 LEU LEU A . n 
A 1 65  LEU 65  328 328 LEU LEU A . n 
A 1 66  THR 66  329 329 THR THR A . n 
A 1 67  LYS 67  330 330 LYS LYS A . n 
A 1 68  PRO 68  331 331 PRO PRO A . n 
A 1 69  TRP 69  332 332 TRP TRP A . n 
A 1 70  ASP 70  333 333 ASP ASP A . n 
A 1 71  ILE 71  334 334 ILE ILE A . n 
A 1 72  ILE 72  335 335 ILE ILE A . n 
A 1 73  PRO 73  336 336 PRO PRO A . n 
A 1 74  MET 74  337 337 MET MET A . n 
A 1 75  VAL 75  338 338 VAL VAL A . n 
A 1 76  THR 76  339 339 THR THR A . n 
A 1 77  GLN 77  340 340 GLN GLN A . n 
A 1 78  MET 78  341 341 MET MET A . n 
A 1 79  ALA 79  342 342 ALA ALA A . n 
A 1 80  MET 80  343 343 MET MET A . n 
A 1 81  THR 81  344 344 THR GLY A . n 
A 1 82  ASP 82  345 ?   ?   ?   A . n 
A 1 83  THR 83  346 ?   ?   ?   A . n 
A 1 84  THR 84  347 ?   ?   ?   A . n 
A 1 85  PRO 85  348 ?   ?   ?   A . n 
A 1 86  PHE 86  349 ?   ?   ?   A . n 
A 1 87  GLY 87  350 ?   ?   ?   A . n 
A 1 88  GLN 88  351 ?   ?   ?   A . n 
A 1 89  GLN 89  352 ?   ?   ?   A . n 
A 1 90  ARG 90  353 ?   ?   ?   A . n 
A 1 91  VAL 91  354 ?   ?   ?   A . n 
A 1 92  PHE 92  355 ?   ?   ?   A . n 
A 1 93  LYS 93  356 356 LYS LYS A . n 
A 1 94  GLU 94  357 357 GLU GLU A . n 
A 1 95  LYS 95  358 358 LYS LYS A . n 
A 1 96  VAL 96  359 359 VAL VAL A . n 
A 1 97  ASP 97  360 360 ASP ASP A . n 
A 1 98  THR 98  361 361 THR THR A . n 
A 1 99  ARG 99  362 362 ARG ARG A . n 
A 1 100 THR 100 363 363 THR THR A . n 
A 1 101 GLN 101 364 364 GLN GLN A . n 
A 1 102 GLU 102 365 365 GLU GLU A . n 
A 1 103 PRO 103 366 366 PRO PRO A . n 
A 1 104 LYS 104 367 367 LYS LYS A . n 
A 1 105 GLU 105 368 368 GLU GLU A . n 
A 1 106 GLY 106 369 369 GLY GLY A . n 
A 1 107 THR 107 370 370 THR THR A . n 
A 1 108 LYS 108 371 371 LYS LYS A . n 
A 1 109 LYS 109 372 372 LYS LYS A . n 
A 1 110 LEU 110 373 373 LEU LEU A . n 
A 1 111 MET 111 374 374 MET MET A . n 
A 1 112 LYS 112 375 375 LYS LYS A . n 
A 1 113 ILE 113 376 376 ILE ILE A . n 
A 1 114 THR 114 377 377 THR THR A . n 
A 1 115 ALA 115 378 378 ALA ALA A . n 
A 1 116 GLU 116 379 379 GLU GLU A . n 
A 1 117 TRP 117 380 380 TRP TRP A . n 
A 1 118 LEU 118 381 381 LEU LEU A . n 
A 1 119 TRP 119 382 382 TRP TRP A . n 
A 1 120 LYS 120 383 383 LYS LYS A . n 
A 1 121 GLU 121 384 384 GLU GLU A . n 
A 1 122 LEU 122 385 385 LEU LEU A . n 
A 1 123 GLY 123 386 386 GLY GLY A . n 
A 1 124 LYS 124 387 387 LYS LYS A . n 
A 1 125 LYS 125 388 388 LYS LYS A . n 
A 1 126 LYS 126 389 389 LYS LYS A . n 
A 1 127 THR 127 390 390 THR THR A . n 
A 1 128 PRO 128 391 391 PRO PRO A . n 
A 1 129 ARG 129 392 392 ARG ARG A . n 
A 1 130 MET 130 393 393 MET MET A . n 
A 1 131 CYS 131 394 394 CYS CYS A . n 
A 1 132 THR 132 395 395 THR THR A . n 
A 1 133 ARG 133 396 396 ARG ARG A . n 
A 1 134 GLU 134 397 397 GLU GLU A . n 
A 1 135 GLU 135 398 398 GLU GLU A . n 
A 1 136 PHE 136 399 399 PHE PHE A . n 
A 1 137 THR 137 400 400 THR THR A . n 
A 1 138 ARG 138 401 401 ARG ARG A . n 
A 1 139 LYS 139 402 402 LYS LYS A . n 
A 1 140 VAL 140 403 403 VAL VAL A . n 
A 1 141 ARG 141 404 404 ARG ARG A . n 
A 1 142 SER 142 405 405 SER SER A . n 
A 1 143 ASN 143 406 406 ASN ASN A . n 
A 1 144 ALA 144 407 407 ALA ALA A . n 
A 1 145 ALA 145 408 408 ALA ALA A . n 
A 1 146 LEU 146 409 409 LEU LEU A . n 
A 1 147 GLY 147 410 410 GLY GLY A . n 
A 1 148 ALA 148 411 411 ALA ALA A . n 
A 1 149 ILE 149 412 412 ILE ILE A . n 
A 1 150 PHE 150 413 ?   ?   ?   A . n 
A 1 151 THR 151 414 ?   ?   ?   A . n 
A 1 152 ASP 152 415 ?   ?   ?   A . n 
A 1 153 GLU 153 416 ?   ?   ?   A . n 
A 1 154 ASN 154 417 ?   ?   ?   A . n 
A 1 155 LYS 155 418 ?   ?   ?   A . n 
A 1 156 TRP 156 419 419 TRP TRP A . n 
A 1 157 LYS 157 420 420 LYS LYS A . n 
A 1 158 SER 158 421 421 SER SER A . n 
A 1 159 ALA 159 422 422 ALA ALA A . n 
A 1 160 ARG 160 423 423 ARG ARG A . n 
A 1 161 GLU 161 424 424 GLU GLU A . n 
A 1 162 ALA 162 425 425 ALA ALA A . n 
A 1 163 VAL 163 426 426 VAL VAL A . n 
A 1 164 GLU 164 427 427 GLU GLU A . n 
A 1 165 ASP 165 428 428 ASP ASP A . n 
A 1 166 SER 166 429 429 SER SER A . n 
A 1 167 GLY 167 430 430 GLY GLY A . n 
A 1 168 PHE 168 431 431 PHE PHE A . n 
A 1 169 TRP 169 432 432 TRP TRP A . n 
A 1 170 GLU 170 433 433 GLU GLU A . n 
A 1 171 LEU 171 434 434 LEU LEU A . n 
A 1 172 VAL 172 435 435 VAL VAL A . n 
A 1 173 ASP 173 436 436 ASP ASP A . n 
A 1 174 LYS 174 437 437 LYS LYS A . n 
A 1 175 GLU 175 438 438 GLU GLU A . n 
A 1 176 ARG 176 439 439 ARG ARG A . n 
A 1 177 ASN 177 440 440 ASN ASN A . n 
A 1 178 LEU 178 441 441 LEU LEU A . n 
A 1 179 HIS 179 442 442 HIS HIS A . n 
A 1 180 LEU 180 443 443 LEU LEU A . n 
A 1 181 GLU 181 444 444 GLU GLU A . n 
A 1 182 GLY 182 445 445 GLY GLY A . n 
A 1 183 LYS 183 446 446 LYS LYS A . n 
A 1 184 CYS 184 447 447 CYS CYS A . n 
A 1 185 GLU 185 448 448 GLU GLU A . n 
A 1 186 THR 186 449 449 THR THR A . n 
A 1 187 CYS 187 450 450 CYS CYS A . n 
A 1 188 VAL 188 451 451 VAL VAL A . n 
A 1 189 TYR 189 452 452 TYR TYR A . n 
A 1 190 ASN 190 453 453 ASN ASN A . n 
A 1 191 MET 191 454 454 MET MET A . n 
A 1 192 MET 192 455 455 MET MET A . n 
A 1 193 GLY 193 456 ?   ?   ?   A . n 
A 1 194 LYS 194 457 ?   ?   ?   A . n 
A 1 195 ARG 195 458 ?   ?   ?   A . n 
A 1 196 GLU 196 459 ?   ?   ?   A . n 
A 1 197 LYS 197 460 ?   ?   ?   A . n 
A 1 198 LYS 198 461 ?   ?   ?   A . n 
A 1 199 LEU 199 462 ?   ?   ?   A . n 
A 1 200 GLY 200 463 ?   ?   ?   A . n 
A 1 201 GLU 201 464 ?   ?   ?   A . n 
A 1 202 PHE 202 465 ?   ?   ?   A . n 
A 1 203 GLY 203 466 ?   ?   ?   A . n 
A 1 204 LYS 204 467 ?   ?   ?   A . n 
A 1 205 ALA 205 468 ?   ?   ?   A . n 
A 1 206 LYS 206 469 ?   ?   ?   A . n 
A 1 207 GLY 207 470 ?   ?   ?   A . n 
A 1 208 SER 208 471 ?   ?   ?   A . n 
A 1 209 ARG 209 472 ?   ?   ?   A . n 
A 1 210 ALA 210 473 473 ALA ALA A . n 
A 1 211 ILE 211 474 474 ILE ILE A . n 
A 1 212 TRP 212 475 475 TRP TRP A . n 
A 1 213 TYR 213 476 476 TYR TYR A . n 
A 1 214 MET 214 477 477 MET MET A . n 
A 1 215 TRP 215 478 478 TRP TRP A . n 
A 1 216 LEU 216 479 479 LEU LEU A . n 
A 1 217 GLY 217 480 480 GLY GLY A . n 
A 1 218 ALA 218 481 481 ALA ALA A . n 
A 1 219 ARG 219 482 482 ARG ARG A . n 
A 1 220 PHE 220 483 483 PHE PHE A . n 
A 1 221 LEU 221 484 484 LEU LEU A . n 
A 1 222 GLU 222 485 485 GLU GLU A . n 
A 1 223 PHE 223 486 486 PHE PHE A . n 
A 1 224 GLU 224 487 487 GLU GLU A . n 
A 1 225 ALA 225 488 488 ALA ALA A . n 
A 1 226 LEU 226 489 489 LEU LEU A . n 
A 1 227 GLY 227 490 490 GLY GLY A . n 
A 1 228 PHE 228 491 491 PHE PHE A . n 
A 1 229 LEU 229 492 492 LEU LEU A . n 
A 1 230 ASN 230 493 493 ASN ASN A . n 
A 1 231 GLU 231 494 494 GLU GLU A . n 
A 1 232 ASP 232 495 495 ASP ASP A . n 
A 1 233 HIS 233 496 496 HIS HIS A . n 
A 1 234 TRP 234 497 497 TRP TRP A . n 
A 1 235 PHE 235 498 498 PHE PHE A . n 
A 1 236 SER 236 499 499 SER SER A . n 
A 1 237 ARG 237 500 500 ARG ARG A . n 
A 1 238 GLU 238 501 501 GLU GLU A . n 
A 1 239 ASN 239 502 502 ASN ASN A . n 
A 1 240 SER 240 503 503 SER SER A . n 
A 1 241 LEU 241 504 504 LEU LEU A . n 
A 1 242 SER 242 505 505 SER SER A . n 
A 1 243 GLY 243 506 506 GLY GLY A . n 
A 1 244 VAL 244 507 507 VAL VAL A . n 
A 1 245 GLU 245 508 508 GLU GLU A . n 
A 1 246 GLY 246 509 509 GLY GLY A . n 
A 1 247 GLU 247 510 510 GLU GLU A . n 
A 1 248 GLY 248 511 511 GLY GLY A . n 
A 1 249 LEU 249 512 512 LEU LEU A . n 
A 1 250 HIS 250 513 513 HIS HIS A . n 
A 1 251 LYS 251 514 514 LYS LYS A . n 
A 1 252 LEU 252 515 515 LEU LEU A . n 
A 1 253 GLY 253 516 516 GLY GLY A . n 
A 1 254 TYR 254 517 517 TYR TYR A . n 
A 1 255 ILE 255 518 518 ILE ILE A . n 
A 1 256 LEU 256 519 519 LEU LEU A . n 
A 1 257 ARG 257 520 520 ARG ARG A . n 
A 1 258 ASP 258 521 521 ASP ASP A . n 
A 1 259 VAL 259 522 522 VAL VAL A . n 
A 1 260 SER 260 523 523 SER SER A . n 
A 1 261 LYS 261 524 524 LYS LYS A . n 
A 1 262 LYS 262 525 525 LYS LYS A . n 
A 1 263 GLU 263 526 526 GLU GLU A . n 
A 1 264 GLY 264 527 527 GLY GLY A . n 
A 1 265 GLY 265 528 528 GLY GLY A . n 
A 1 266 ALA 266 529 529 ALA ALA A . n 
A 1 267 MET 267 530 530 MET MET A . n 
A 1 268 TYR 268 531 531 TYR TYR A . n 
A 1 269 ALA 269 532 532 ALA ALA A . n 
A 1 270 ASP 270 533 533 ASP ASP A . n 
A 1 271 ASP 271 534 534 ASP ASP A . n 
A 1 272 THR 272 535 535 THR THR A . n 
A 1 273 ALA 273 536 536 ALA ALA A . n 
A 1 274 GLY 274 537 537 GLY GLY A . n 
A 1 275 TRP 275 538 538 TRP TRP A . n 
A 1 276 ASP 276 539 539 ASP ASP A . n 
A 1 277 THR 277 540 540 THR THR A . n 
A 1 278 ARG 278 541 541 ARG ARG A . n 
A 1 279 ILE 279 542 542 ILE ILE A . n 
A 1 280 THR 280 543 543 THR THR A . n 
A 1 281 LEU 281 544 544 LEU LEU A . n 
A 1 282 GLU 282 545 545 GLU GLU A . n 
A 1 283 ASP 283 546 546 ASP ASP A . n 
A 1 284 LEU 284 547 547 LEU LEU A . n 
A 1 285 LYS 285 548 548 LYS LYS A . n 
A 1 286 ASN 286 549 549 ASN ASN A . n 
A 1 287 GLU 287 550 550 GLU GLU A . n 
A 1 288 GLU 288 551 551 GLU GLU A . n 
A 1 289 MET 289 552 552 MET MET A . n 
A 1 290 VAL 290 553 553 VAL VAL A . n 
A 1 291 THR 291 554 554 THR THR A . n 
A 1 292 ASN 292 555 555 ASN ASN A . n 
A 1 293 HIS 293 556 556 HIS HIS A . n 
A 1 294 MET 294 557 557 MET MET A . n 
A 1 295 GLU 295 558 558 GLU GLU A . n 
A 1 296 GLY 296 559 559 GLY GLY A . n 
A 1 297 GLU 297 560 560 GLU GLU A . n 
A 1 298 HIS 298 561 561 HIS HIS A . n 
A 1 299 LYS 299 562 562 LYS LYS A . n 
A 1 300 LYS 300 563 563 LYS LYS A . n 
A 1 301 LEU 301 564 564 LEU LEU A . n 
A 1 302 ALA 302 565 565 ALA ALA A . n 
A 1 303 GLU 303 566 566 GLU GLU A . n 
A 1 304 ALA 304 567 567 ALA ALA A . n 
A 1 305 ILE 305 568 568 ILE ILE A . n 
A 1 306 PHE 306 569 569 PHE PHE A . n 
A 1 307 LYS 307 570 570 LYS LYS A . n 
A 1 308 LEU 308 571 571 LEU LEU A . n 
A 1 309 THR 309 572 572 THR THR A . n 
A 1 310 TYR 310 573 573 TYR TYR A . n 
A 1 311 GLN 311 574 574 GLN GLN A . n 
A 1 312 ASN 312 575 575 ASN ASN A . n 
A 1 313 LYS 313 576 576 LYS LYS A . n 
A 1 314 VAL 314 577 577 VAL VAL A . n 
A 1 315 VAL 315 578 578 VAL VAL A . n 
A 1 316 ARG 316 579 579 ARG ARG A . n 
A 1 317 VAL 317 580 580 VAL VAL A . n 
A 1 318 GLN 318 581 581 GLN GLN A . n 
A 1 319 ARG 319 582 582 ARG ARG A . n 
A 1 320 PRO 320 583 583 PRO PRO A . n 
A 1 321 THR 321 584 584 THR THR A . n 
A 1 322 PRO 322 585 ?   ?   ?   A . n 
A 1 323 ARG 323 586 ?   ?   ?   A . n 
A 1 324 GLY 324 587 ?   ?   ?   A . n 
A 1 325 THR 325 588 588 THR THR A . n 
A 1 326 VAL 326 589 589 VAL VAL A . n 
A 1 327 MET 327 590 590 MET MET A . n 
A 1 328 ASP 328 591 591 ASP ASP A . n 
A 1 329 ILE 329 592 592 ILE ILE A . n 
A 1 330 ILE 330 593 593 ILE ILE A . n 
A 1 331 SER 331 594 594 SER SER A . n 
A 1 332 ARG 332 595 595 ARG ARG A . n 
A 1 333 ARG 333 596 596 ARG ARG A . n 
A 1 334 ASP 334 597 597 ASP ASP A . n 
A 1 335 GLN 335 598 598 GLN GLN A . n 
A 1 336 ARG 336 599 599 ARG ARG A . n 
A 1 337 GLY 337 600 600 GLY GLY A . n 
A 1 338 SER 338 601 601 SER SER A . n 
A 1 339 GLY 339 602 602 GLY GLY A . n 
A 1 340 GLN 340 603 603 GLN GLN A . n 
A 1 341 VAL 341 604 604 VAL VAL A . n 
A 1 342 VAL 342 605 605 VAL VAL A . n 
A 1 343 THR 343 606 606 THR THR A . n 
A 1 344 TYR 344 607 607 TYR TYR A . n 
A 1 345 GLY 345 608 608 GLY GLY A . n 
A 1 346 LEU 346 609 609 LEU LEU A . n 
A 1 347 ASN 347 610 610 ASN ASN A . n 
A 1 348 THR 348 611 611 THR THR A . n 
A 1 349 PHE 349 612 612 PHE PHE A . n 
A 1 350 THR 350 613 613 THR THR A . n 
A 1 351 ASN 351 614 614 ASN ASN A . n 
A 1 352 MET 352 615 615 MET MET A . n 
A 1 353 GLU 353 616 616 GLU GLU A . n 
A 1 354 ALA 354 617 617 ALA ALA A . n 
A 1 355 GLN 355 618 618 GLN GLN A . n 
A 1 356 LEU 356 619 619 LEU LEU A . n 
A 1 357 ILE 357 620 620 ILE ILE A . n 
A 1 358 ARG 358 621 621 ARG ARG A . n 
A 1 359 GLN 359 622 622 GLN GLN A . n 
A 1 360 MET 360 623 623 MET MET A . n 
A 1 361 GLU 361 624 624 GLU GLU A . n 
A 1 362 GLY 362 625 625 GLY GLY A . n 
A 1 363 GLU 363 626 626 GLU GLU A . n 
A 1 364 GLY 364 627 627 GLY GLY A . n 
A 1 365 VAL 365 628 628 VAL VAL A . n 
A 1 366 PHE 366 629 629 PHE PHE A . n 
A 1 367 LYS 367 630 630 LYS LYS A . n 
A 1 368 SER 368 631 631 SER SER A . n 
A 1 369 ILE 369 632 632 ILE ILE A . n 
A 1 370 GLN 370 633 633 GLN GLN A . n 
A 1 371 HIS 371 634 634 HIS HIS A . n 
A 1 372 LEU 372 635 635 LEU LEU A . n 
A 1 373 THR 373 636 636 THR THR A . n 
A 1 374 VAL 374 637 637 VAL VAL A . n 
A 1 375 THR 375 638 638 THR THR A . n 
A 1 376 GLU 376 639 639 GLU GLU A . n 
A 1 377 GLU 377 640 640 GLU GLU A . n 
A 1 378 ILE 378 641 641 ILE ILE A . n 
A 1 379 ALA 379 642 642 ALA ALA A . n 
A 1 380 VAL 380 643 643 VAL VAL A . n 
A 1 381 LYS 381 644 644 LYS LYS A . n 
A 1 382 ASN 382 645 645 ASN ASN A . n 
A 1 383 TRP 383 646 646 TRP TRP A . n 
A 1 384 LEU 384 647 647 LEU LEU A . n 
A 1 385 VAL 385 648 648 VAL VAL A . n 
A 1 386 ARG 386 649 649 ARG ARG A . n 
A 1 387 VAL 387 650 650 VAL VAL A . n 
A 1 388 GLY 388 651 651 GLY GLY A . n 
A 1 389 ARG 389 652 652 ARG ARG A . n 
A 1 390 GLU 390 653 653 GLU GLU A . n 
A 1 391 ARG 391 654 654 ARG ARG A . n 
A 1 392 LEU 392 655 655 LEU LEU A . n 
A 1 393 SER 393 656 656 SER SER A . n 
A 1 394 ARG 394 657 657 ARG ARG A . n 
A 1 395 MET 395 658 658 MET MET A . n 
A 1 396 ALA 396 659 659 ALA ALA A . n 
A 1 397 ILE 397 660 660 ILE ILE A . n 
A 1 398 SER 398 661 661 SER SER A . n 
A 1 399 GLY 399 662 662 GLY GLY A . n 
A 1 400 ASP 400 663 663 ASP ASP A . n 
A 1 401 ASP 401 664 664 ASP ASP A . n 
A 1 402 CYS 402 665 665 CYS CYS A . n 
A 1 403 VAL 403 666 666 VAL VAL A . n 
A 1 404 VAL 404 667 667 VAL VAL A . n 
A 1 405 LYS 405 668 668 LYS LYS A . n 
A 1 406 PRO 406 669 669 PRO PRO A . n 
A 1 407 LEU 407 670 670 LEU LEU A . n 
A 1 408 ASP 408 671 671 ASP ASP A . n 
A 1 409 ASP 409 672 672 ASP ASP A . n 
A 1 410 ARG 410 673 673 ARG ARG A . n 
A 1 411 PHE 411 674 674 PHE PHE A . n 
A 1 412 ALA 412 675 675 ALA ALA A . n 
A 1 413 SER 413 676 676 SER SER A . n 
A 1 414 ALA 414 677 677 ALA ALA A . n 
A 1 415 LEU 415 678 678 LEU LEU A . n 
A 1 416 THR 416 679 679 THR THR A . n 
A 1 417 ALA 417 680 680 ALA ALA A . n 
A 1 418 LEU 418 681 681 LEU LEU A . n 
A 1 419 ASN 419 682 682 ASN ASN A . n 
A 1 420 ASP 420 683 683 ASP ASP A . n 
A 1 421 MET 421 684 684 MET MET A . n 
A 1 422 GLY 422 685 685 GLY GLY A . n 
A 1 423 LYS 423 686 686 LYS LYS A . n 
A 1 424 VAL 424 687 687 VAL VAL A . n 
A 1 425 ARG 425 688 688 ARG ARG A . n 
A 1 426 LYS 426 689 689 LYS LYS A . n 
A 1 427 ASP 427 690 690 ASP ASP A . n 
A 1 428 ILE 428 691 691 ILE ILE A . n 
A 1 429 GLN 429 692 692 GLN GLN A . n 
A 1 430 GLN 430 693 693 GLN GLN A . n 
A 1 431 TRP 431 694 694 TRP TRP A . n 
A 1 432 GLU 432 695 695 GLU GLU A . n 
A 1 433 PRO 433 696 696 PRO PRO A . n 
A 1 434 SER 434 697 697 SER SER A . n 
A 1 435 ARG 435 698 698 ARG ARG A . n 
A 1 436 GLY 436 699 699 GLY GLY A . n 
A 1 437 TRP 437 700 700 TRP TRP A . n 
A 1 438 ASN 438 701 701 ASN ASN A . n 
A 1 439 ASP 439 702 702 ASP ASP A . n 
A 1 440 TRP 440 703 703 TRP TRP A . n 
A 1 441 THR 441 704 704 THR THR A . n 
A 1 442 GLN 442 705 705 GLN GLN A . n 
A 1 443 VAL 443 706 706 VAL VAL A . n 
A 1 444 PRO 444 707 707 PRO PRO A . n 
A 1 445 PHE 445 708 708 PHE PHE A . n 
A 1 446 CYS 446 709 709 CYS CYS A . n 
A 1 447 SER 447 710 710 SER SER A . n 
A 1 448 HIS 448 711 711 HIS HIS A . n 
A 1 449 HIS 449 712 712 HIS HIS A . n 
A 1 450 PHE 450 713 713 PHE PHE A . n 
A 1 451 HIS 451 714 714 HIS HIS A . n 
A 1 452 GLU 452 715 715 GLU GLU A . n 
A 1 453 LEU 453 716 716 LEU LEU A . n 
A 1 454 ILE 454 717 717 ILE ILE A . n 
A 1 455 MET 455 718 718 MET MET A . n 
A 1 456 LYS 456 719 719 LYS LYS A . n 
A 1 457 ASP 457 720 720 ASP ASP A . n 
A 1 458 GLY 458 721 721 GLY GLY A . n 
A 1 459 ARG 459 722 722 ARG ARG A . n 
A 1 460 VAL 460 723 723 VAL VAL A . n 
A 1 461 LEU 461 724 724 LEU LEU A . n 
A 1 462 VAL 462 725 725 VAL VAL A . n 
A 1 463 VAL 463 726 726 VAL VAL A . n 
A 1 464 PRO 464 727 727 PRO PRO A . n 
A 1 465 CYS 465 728 728 CYS CYS A . n 
A 1 466 ARG 466 729 729 ARG ARG A . n 
A 1 467 ASN 467 730 730 ASN ASN A . n 
A 1 468 GLN 468 731 731 GLN GLN A . n 
A 1 469 ASP 469 732 732 ASP ASP A . n 
A 1 470 GLU 470 733 733 GLU GLU A . n 
A 1 471 LEU 471 734 734 LEU LEU A . n 
A 1 472 ILE 472 735 735 ILE ILE A . n 
A 1 473 GLY 473 736 736 GLY GLY A . n 
A 1 474 ARG 474 737 737 ARG ARG A . n 
A 1 475 ALA 475 738 738 ALA ALA A . n 
A 1 476 ARG 476 739 739 ARG ARG A . n 
A 1 477 ILE 477 740 740 ILE ILE A . n 
A 1 478 SER 478 741 741 SER SER A . n 
A 1 479 GLN 479 742 742 GLN GLN A . n 
A 1 480 GLY 480 743 743 GLY GLY A . n 
A 1 481 ALA 481 744 744 ALA ALA A . n 
A 1 482 GLY 482 745 745 GLY GLY A . n 
A 1 483 TRP 483 746 746 TRP TRP A . n 
A 1 484 SER 484 747 747 SER SER A . n 
A 1 485 LEU 485 748 748 LEU LEU A . n 
A 1 486 ARG 486 749 749 ARG ARG A . n 
A 1 487 GLU 487 750 750 GLU GLU A . n 
A 1 488 THR 488 751 751 THR THR A . n 
A 1 489 ALA 489 752 752 ALA ALA A . n 
A 1 490 CYS 490 753 753 CYS CYS A . n 
A 1 491 LEU 491 754 754 LEU LEU A . n 
A 1 492 GLY 492 755 755 GLY GLY A . n 
A 1 493 LYS 493 756 756 LYS LYS A . n 
A 1 494 SER 494 757 757 SER SER A . n 
A 1 495 TYR 495 758 758 TYR TYR A . n 
A 1 496 ALA 496 759 759 ALA ALA A . n 
A 1 497 GLN 497 760 760 GLN GLN A . n 
A 1 498 MET 498 761 761 MET MET A . n 
A 1 499 TRP 499 762 762 TRP TRP A . n 
A 1 500 SER 500 763 763 SER SER A . n 
A 1 501 LEU 501 764 764 LEU LEU A . n 
A 1 502 MET 502 765 765 MET MET A . n 
A 1 503 TYR 503 766 766 TYR TYR A . n 
A 1 504 PHE 504 767 767 PHE PHE A . n 
A 1 505 HIS 505 768 768 HIS HIS A . n 
A 1 506 ARG 506 769 769 ARG ARG A . n 
A 1 507 ARG 507 770 770 ARG ARG A . n 
A 1 508 ASP 508 771 771 ASP ASP A . n 
A 1 509 LEU 509 772 772 LEU LEU A . n 
A 1 510 ARG 510 773 773 ARG ARG A . n 
A 1 511 LEU 511 774 774 LEU LEU A . n 
A 1 512 ALA 512 775 775 ALA ALA A . n 
A 1 513 ALA 513 776 776 ALA ALA A . n 
A 1 514 ASN 514 777 777 ASN ASN A . n 
A 1 515 ALA 515 778 778 ALA ALA A . n 
A 1 516 ILE 516 779 779 ILE ILE A . n 
A 1 517 CYS 517 780 780 CYS CYS A . n 
A 1 518 SER 518 781 781 SER SER A . n 
A 1 519 ALA 519 782 782 ALA ALA A . n 
A 1 520 VAL 520 783 783 VAL VAL A . n 
A 1 521 PRO 521 784 784 PRO PRO A . n 
A 1 522 SER 522 785 785 SER SER A . n 
A 1 523 HIS 523 786 786 HIS HIS A . n 
A 1 524 TRP 524 787 787 TRP TRP A . n 
A 1 525 VAL 525 788 788 VAL VAL A . n 
A 1 526 PRO 526 789 789 PRO PRO A . n 
A 1 527 THR 527 790 790 THR THR A . n 
A 1 528 SER 528 791 791 SER SER A . n 
A 1 529 ARG 529 792 792 ARG ARG A . n 
A 1 530 THR 530 793 ?   ?   ?   A . n 
A 1 531 THR 531 794 ?   ?   ?   A . n 
A 1 532 TRP 532 795 ?   ?   ?   A . n 
A 1 533 SER 533 796 ?   ?   ?   A . n 
A 1 534 ILE 534 797 ?   ?   ?   A . n 
A 1 535 HIS 535 798 ?   ?   ?   A . n 
A 1 536 ALA 536 799 799 ALA ALA A . n 
A 1 537 THR 537 800 800 THR THR A . n 
A 1 538 HIS 538 801 801 HIS HIS A . n 
A 1 539 GLU 539 802 802 GLU GLU A . n 
A 1 540 TRP 540 803 803 TRP TRP A . n 
A 1 541 MET 541 804 804 MET MET A . n 
A 1 542 THR 542 805 805 THR THR A . n 
A 1 543 THR 543 806 806 THR THR A . n 
A 1 544 GLU 544 807 807 GLU GLU A . n 
A 1 545 ASP 545 808 808 ASP ASP A . n 
A 1 546 MET 546 809 809 MET MET A . n 
A 1 547 LEU 547 810 810 LEU LEU A . n 
A 1 548 THR 548 811 811 THR THR A . n 
A 1 549 VAL 549 812 812 VAL VAL A . n 
A 1 550 TRP 550 813 813 TRP TRP A . n 
A 1 551 ASN 551 814 814 ASN ASN A . n 
A 1 552 ARG 552 815 815 ARG ARG A . n 
A 1 553 VAL 553 816 816 VAL VAL A . n 
A 1 554 TRP 554 817 817 TRP TRP A . n 
A 1 555 ILE 555 818 818 ILE ILE A . n 
A 1 556 GLN 556 819 819 GLN GLN A . n 
A 1 557 GLU 557 820 820 GLU GLU A . n 
A 1 558 ASN 558 821 821 ASN ASN A . n 
A 1 559 PRO 559 822 822 PRO PRO A . n 
A 1 560 TRP 560 823 823 TRP TRP A . n 
A 1 561 MET 561 824 824 MET MET A . n 
A 1 562 GLU 562 825 825 GLU GLU A . n 
A 1 563 ASP 563 826 826 ASP ASP A . n 
A 1 564 LYS 564 827 827 LYS LYS A . n 
A 1 565 THR 565 828 828 THR THR A . n 
A 1 566 PRO 566 829 829 PRO PRO A . n 
A 1 567 VAL 567 830 830 VAL VAL A . n 
A 1 568 GLU 568 831 831 GLU GLU A . n 
A 1 569 SER 569 832 832 SER SER A . n 
A 1 570 TRP 570 833 833 TRP TRP A . n 
A 1 571 GLU 571 834 834 GLU GLU A . n 
A 1 572 GLU 572 835 835 GLU GLU A . n 
A 1 573 ILE 573 836 836 ILE ILE A . n 
A 1 574 PRO 574 837 837 PRO PRO A . n 
A 1 575 TYR 575 838 838 TYR TYR A . n 
A 1 576 LEU 576 839 839 LEU LEU A . n 
A 1 577 GLY 577 840 840 GLY GLY A . n 
A 1 578 LYS 578 841 841 LYS LYS A . n 
A 1 579 ARG 579 842 842 ARG ARG A . n 
A 1 580 GLU 580 843 843 GLU GLU A . n 
A 1 581 ASP 581 844 844 ASP ASP A . n 
A 1 582 GLN 582 845 845 GLN GLN A . n 
A 1 583 TRP 583 846 846 TRP TRP A . n 
A 1 584 CYS 584 847 847 CYS CYS A . n 
A 1 585 GLY 585 848 848 GLY GLY A . n 
A 1 586 SER 586 849 849 SER SER A . n 
A 1 587 LEU 587 850 850 LEU LEU A . n 
A 1 588 ILE 588 851 851 ILE ILE A . n 
A 1 589 GLY 589 852 852 GLY GLY A . n 
A 1 590 LEU 590 853 853 LEU LEU A . n 
A 1 591 THR 591 854 854 THR THR A . n 
A 1 592 SER 592 855 855 SER SER A . n 
A 1 593 ARG 593 856 856 ARG ARG A . n 
A 1 594 ALA 594 857 857 ALA ALA A . n 
A 1 595 THR 595 858 858 THR THR A . n 
A 1 596 TRP 596 859 859 TRP TRP A . n 
A 1 597 ALA 597 860 860 ALA ALA A . n 
A 1 598 LYS 598 861 861 LYS LYS A . n 
A 1 599 ASN 599 862 862 ASN ASN A . n 
A 1 600 ILE 600 863 863 ILE ILE A . n 
A 1 601 GLN 601 864 864 GLN GLN A . n 
A 1 602 THR 602 865 865 THR THR A . n 
A 1 603 ALA 603 866 866 ALA ALA A . n 
A 1 604 ILE 604 867 867 ILE ILE A . n 
A 1 605 ASN 605 868 868 ASN ASN A . n 
A 1 606 GLN 606 869 869 GLN GLN A . n 
A 1 607 VAL 607 870 870 VAL VAL A . n 
A 1 608 ARG 608 871 871 ARG ARG A . n 
A 1 609 SER 609 872 872 SER SER A . n 
A 1 610 LEU 610 873 873 LEU LEU A . n 
A 1 611 ILE 611 874 874 ILE ILE A . n 
A 1 612 GLY 612 875 875 GLY GLY A . n 
A 1 613 ASN 613 876 876 ASN ASN A . n 
A 1 614 GLU 614 877 877 GLU GLU A . n 
A 1 615 GLU 615 878 878 GLU GLU A . n 
A 1 616 TYR 616 879 879 TYR TYR A . n 
A 1 617 THR 617 880 880 THR THR A . n 
A 1 618 ASP 618 881 881 ASP ASP A . n 
A 1 619 TYR 619 882 882 TYR TYR A . n 
A 1 620 MET 620 883 883 MET MET A . n 
A 1 621 PRO 621 884 884 PRO PRO A . n 
A 1 622 SER 622 885 885 SER SER A . n 
A 1 623 MET 623 886 886 MET MET A . n 
A 1 624 LYS 624 887 887 LYS LYS A . n 
A 1 625 ARG 625 888 888 ARG ARG A . n 
A 1 626 PHE 626 889 889 PHE PHE A . n 
A 1 627 ARG 627 890 890 ARG ARG A . n 
A 1 628 ARG 628 891 891 ARG ARG A . n 
A 1 629 GLU 629 892 ?   ?   ?   A . n 
A 1 630 GLU 630 893 ?   ?   ?   A . n 
A 1 631 GLU 631 894 ?   ?   ?   A . n 
A 1 632 GLU 632 895 ?   ?   ?   A . n 
A 1 633 ALA 633 896 ?   ?   ?   A . n 
A 1 634 GLY 634 897 ?   ?   ?   A . n 
A 1 635 VAL 635 898 ?   ?   ?   A . n 
A 1 636 LEU 636 899 ?   ?   ?   A . n 
A 1 637 TRP 637 900 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        O3D 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   O3D 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 ZN  1   1001 1001 ZN  ZN  A . 
C 2 ZN  1   1002 1002 ZN  ZN  A . 
D 3 MES 1   1003 1004 MES MES A . 
E 4 DMS 1   1004 1530 DMS DMS A . 
F 4 DMS 1   1005 1601 DMS DMS A . 
G 4 DMS 1   1006 1602 DMS DMS A . 
H 5 PO4 1   1007 1604 PO4 PO4 A . 
I 5 PO4 1   1008 1606 PO4 PO4 A . 
J 6 PEG 1   1009 1607 PEG PEG A . 
K 7 O3D 1   1010 1707 O3D LIG A . 
L 8 CL  1   1011 1    CL  CL  A . 
M 9 HOH 1   1101 11   HOH HOH A . 
M 9 HOH 2   1102 341  HOH HOH A . 
M 9 HOH 3   1103 175  HOH HOH A . 
M 9 HOH 4   1104 153  HOH HOH A . 
M 9 HOH 5   1105 254  HOH HOH A . 
M 9 HOH 6   1106 189  HOH HOH A . 
M 9 HOH 7   1107 214  HOH HOH A . 
M 9 HOH 8   1108 125  HOH HOH A . 
M 9 HOH 9   1109 464  HOH HOH A . 
M 9 HOH 10  1110 36   HOH HOH A . 
M 9 HOH 11  1111 112  HOH HOH A . 
M 9 HOH 12  1112 267  HOH HOH A . 
M 9 HOH 13  1113 176  HOH HOH A . 
M 9 HOH 14  1114 247  HOH HOH A . 
M 9 HOH 15  1115 320  HOH HOH A . 
M 9 HOH 16  1116 165  HOH HOH A . 
M 9 HOH 17  1117 202  HOH HOH A . 
M 9 HOH 18  1118 195  HOH HOH A . 
M 9 HOH 19  1119 460  HOH HOH A . 
M 9 HOH 20  1120 16   HOH HOH A . 
M 9 HOH 21  1121 35   HOH HOH A . 
M 9 HOH 22  1122 206  HOH HOH A . 
M 9 HOH 23  1123 348  HOH HOH A . 
M 9 HOH 24  1124 277  HOH HOH A . 
M 9 HOH 25  1125 227  HOH HOH A . 
M 9 HOH 26  1126 273  HOH HOH A . 
M 9 HOH 27  1127 174  HOH HOH A . 
M 9 HOH 28  1128 193  HOH HOH A . 
M 9 HOH 29  1129 191  HOH HOH A . 
M 9 HOH 30  1130 242  HOH HOH A . 
M 9 HOH 31  1131 58   HOH HOH A . 
M 9 HOH 32  1132 179  HOH HOH A . 
M 9 HOH 33  1133 187  HOH HOH A . 
M 9 HOH 34  1134 287  HOH HOH A . 
M 9 HOH 35  1135 239  HOH HOH A . 
M 9 HOH 36  1136 149  HOH HOH A . 
M 9 HOH 37  1137 217  HOH HOH A . 
M 9 HOH 38  1138 251  HOH HOH A . 
M 9 HOH 39  1139 197  HOH HOH A . 
M 9 HOH 40  1140 266  HOH HOH A . 
M 9 HOH 41  1141 204  HOH HOH A . 
M 9 HOH 42  1142 185  HOH HOH A . 
M 9 HOH 43  1143 265  HOH HOH A . 
M 9 HOH 44  1144 34   HOH HOH A . 
M 9 HOH 45  1145 226  HOH HOH A . 
M 9 HOH 46  1146 232  HOH HOH A . 
M 9 HOH 47  1147 180  HOH HOH A . 
M 9 HOH 48  1148 205  HOH HOH A . 
M 9 HOH 49  1149 201  HOH HOH A . 
M 9 HOH 50  1150 52   HOH HOH A . 
M 9 HOH 51  1151 211  HOH HOH A . 
M 9 HOH 52  1152 396  HOH HOH A . 
M 9 HOH 53  1153 274  HOH HOH A . 
M 9 HOH 54  1154 151  HOH HOH A . 
M 9 HOH 55  1155 178  HOH HOH A . 
M 9 HOH 56  1156 258  HOH HOH A . 
M 9 HOH 57  1157 86   HOH HOH A . 
M 9 HOH 58  1158 327  HOH HOH A . 
M 9 HOH 59  1159 198  HOH HOH A . 
M 9 HOH 60  1160 210  HOH HOH A . 
M 9 HOH 61  1161 166  HOH HOH A . 
M 9 HOH 62  1162 292  HOH HOH A . 
M 9 HOH 63  1163 288  HOH HOH A . 
M 9 HOH 64  1164 96   HOH HOH A . 
M 9 HOH 65  1165 110  HOH HOH A . 
M 9 HOH 66  1166 257  HOH HOH A . 
M 9 HOH 67  1167 23   HOH HOH A . 
M 9 HOH 68  1168 312  HOH HOH A . 
M 9 HOH 69  1169 37   HOH HOH A . 
M 9 HOH 70  1170 463  HOH HOH A . 
M 9 HOH 71  1171 248  HOH HOH A . 
M 9 HOH 72  1172 220  HOH HOH A . 
M 9 HOH 73  1173 225  HOH HOH A . 
M 9 HOH 74  1174 262  HOH HOH A . 
M 9 HOH 75  1175 224  HOH HOH A . 
M 9 HOH 76  1176 87   HOH HOH A . 
M 9 HOH 77  1177 184  HOH HOH A . 
M 9 HOH 78  1178 236  HOH HOH A . 
M 9 HOH 79  1179 144  HOH HOH A . 
M 9 HOH 80  1180 216  HOH HOH A . 
M 9 HOH 81  1181 329  HOH HOH A . 
M 9 HOH 82  1182 234  HOH HOH A . 
M 9 HOH 83  1183 281  HOH HOH A . 
M 9 HOH 84  1184 190  HOH HOH A . 
M 9 HOH 85  1185 150  HOH HOH A . 
M 9 HOH 86  1186 186  HOH HOH A . 
M 9 HOH 87  1187 143  HOH HOH A . 
M 9 HOH 88  1188 244  HOH HOH A . 
M 9 HOH 89  1189 223  HOH HOH A . 
M 9 HOH 90  1190 199  HOH HOH A . 
M 9 HOH 91  1191 177  HOH HOH A . 
M 9 HOH 92  1192 306  HOH HOH A . 
M 9 HOH 93  1193 215  HOH HOH A . 
M 9 HOH 94  1194 89   HOH HOH A . 
M 9 HOH 95  1195 3    HOH HOH A . 
M 9 HOH 96  1196 346  HOH HOH A . 
M 9 HOH 97  1197 221  HOH HOH A . 
M 9 HOH 98  1198 192  HOH HOH A . 
M 9 HOH 99  1199 250  HOH HOH A . 
M 9 HOH 100 1200 268  HOH HOH A . 
M 9 HOH 101 1201 307  HOH HOH A . 
M 9 HOH 102 1202 2    HOH HOH A . 
M 9 HOH 103 1203 293  HOH HOH A . 
M 9 HOH 104 1204 365  HOH HOH A . 
M 9 HOH 105 1205 213  HOH HOH A . 
M 9 HOH 106 1206 212  HOH HOH A . 
M 9 HOH 107 1207 203  HOH HOH A . 
M 9 HOH 108 1208 209  HOH HOH A . 
M 9 HOH 109 1209 401  HOH HOH A . 
M 9 HOH 110 1210 298  HOH HOH A . 
M 9 HOH 111 1211 7    HOH HOH A . 
M 9 HOH 112 1212 462  HOH HOH A . 
M 9 HOH 113 1213 196  HOH HOH A . 
M 9 HOH 114 1214 152  HOH HOH A . 
M 9 HOH 115 1215 238  HOH HOH A . 
M 9 HOH 116 1216 323  HOH HOH A . 
M 9 HOH 117 1217 240  HOH HOH A . 
M 9 HOH 118 1218 246  HOH HOH A . 
M 9 HOH 119 1219 296  HOH HOH A . 
M 9 HOH 120 1220 256  HOH HOH A . 
M 9 HOH 121 1221 318  HOH HOH A . 
M 9 HOH 122 1222 272  HOH HOH A . 
M 9 HOH 123 1223 207  HOH HOH A . 
M 9 HOH 124 1224 395  HOH HOH A . 
M 9 HOH 125 1225 311  HOH HOH A . 
M 9 HOH 126 1226 333  HOH HOH A . 
M 9 HOH 127 1227 255  HOH HOH A . 
M 9 HOH 128 1228 188  HOH HOH A . 
M 9 HOH 129 1229 280  HOH HOH A . 
M 9 HOH 130 1230 182  HOH HOH A . 
M 9 HOH 131 1231 25   HOH HOH A . 
M 9 HOH 132 1232 303  HOH HOH A . 
M 9 HOH 133 1233 6    HOH HOH A . 
M 9 HOH 134 1234 308  HOH HOH A . 
M 9 HOH 135 1235 104  HOH HOH A . 
M 9 HOH 136 1236 82   HOH HOH A . 
M 9 HOH 137 1237 45   HOH HOH A . 
M 9 HOH 138 1238 243  HOH HOH A . 
M 9 HOH 139 1239 368  HOH HOH A . 
M 9 HOH 140 1240 310  HOH HOH A . 
M 9 HOH 141 1241 219  HOH HOH A . 
M 9 HOH 142 1242 222  HOH HOH A . 
M 9 HOH 143 1243 325  HOH HOH A . 
M 9 HOH 144 1244 289  HOH HOH A . 
M 9 HOH 145 1245 331  HOH HOH A . 
M 9 HOH 146 1246 294  HOH HOH A . 
M 9 HOH 147 1247 231  HOH HOH A . 
M 9 HOH 148 1248 300  HOH HOH A . 
M 9 HOH 149 1249 252  HOH HOH A . 
M 9 HOH 150 1250 405  HOH HOH A . 
M 9 HOH 151 1251 245  HOH HOH A . 
M 9 HOH 152 1252 90   HOH HOH A . 
M 9 HOH 153 1253 69   HOH HOH A . 
M 9 HOH 154 1254 345  HOH HOH A . 
M 9 HOH 155 1255 30   HOH HOH A . 
M 9 HOH 156 1256 39   HOH HOH A . 
M 9 HOH 157 1257 271  HOH HOH A . 
M 9 HOH 158 1258 145  HOH HOH A . 
M 9 HOH 159 1259 109  HOH HOH A . 
M 9 HOH 160 1260 278  HOH HOH A . 
M 9 HOH 161 1261 316  HOH HOH A . 
M 9 HOH 162 1262 275  HOH HOH A . 
M 9 HOH 163 1263 339  HOH HOH A . 
M 9 HOH 164 1264 279  HOH HOH A . 
M 9 HOH 165 1265 27   HOH HOH A . 
M 9 HOH 166 1266 319  HOH HOH A . 
M 9 HOH 167 1267 285  HOH HOH A . 
M 9 HOH 168 1268 350  HOH HOH A . 
M 9 HOH 169 1269 241  HOH HOH A . 
M 9 HOH 170 1270 347  HOH HOH A . 
M 9 HOH 171 1271 309  HOH HOH A . 
M 9 HOH 172 1272 136  HOH HOH A . 
M 9 HOH 173 1273 458  HOH HOH A . 
M 9 HOH 174 1274 47   HOH HOH A . 
M 9 HOH 175 1275 194  HOH HOH A . 
M 9 HOH 176 1276 322  HOH HOH A . 
M 9 HOH 177 1277 5    HOH HOH A . 
M 9 HOH 178 1278 302  HOH HOH A . 
M 9 HOH 179 1279 313  HOH HOH A . 
M 9 HOH 180 1280 260  HOH HOH A . 
M 9 HOH 181 1281 387  HOH HOH A . 
M 9 HOH 182 1282 26   HOH HOH A . 
M 9 HOH 183 1283 355  HOH HOH A . 
M 9 HOH 184 1284 249  HOH HOH A . 
M 9 HOH 185 1285 233  HOH HOH A . 
M 9 HOH 186 1286 33   HOH HOH A . 
M 9 HOH 187 1287 91   HOH HOH A . 
M 9 HOH 188 1288 100  HOH HOH A . 
M 9 HOH 189 1289 389  HOH HOH A . 
M 9 HOH 190 1290 336  HOH HOH A . 
M 9 HOH 191 1291 315  HOH HOH A . 
M 9 HOH 192 1292 357  HOH HOH A . 
M 9 HOH 193 1293 370  HOH HOH A . 
M 9 HOH 194 1294 218  HOH HOH A . 
M 9 HOH 195 1295 31   HOH HOH A . 
M 9 HOH 196 1296 235  HOH HOH A . 
M 9 HOH 197 1297 321  HOH HOH A . 
M 9 HOH 198 1298 270  HOH HOH A . 
M 9 HOH 199 1299 358  HOH HOH A . 
M 9 HOH 200 1300 381  HOH HOH A . 
M 9 HOH 201 1301 290  HOH HOH A . 
M 9 HOH 202 1302 392  HOH HOH A . 
M 9 HOH 203 1303 92   HOH HOH A . 
M 9 HOH 204 1304 377  HOH HOH A . 
M 9 HOH 205 1305 15   HOH HOH A . 
M 9 HOH 206 1306 81   HOH HOH A . 
M 9 HOH 207 1307 83   HOH HOH A . 
M 9 HOH 208 1308 342  HOH HOH A . 
M 9 HOH 209 1309 129  HOH HOH A . 
M 9 HOH 210 1310 330  HOH HOH A . 
M 9 HOH 211 1311 328  HOH HOH A . 
M 9 HOH 212 1312 304  HOH HOH A . 
M 9 HOH 213 1313 111  HOH HOH A . 
M 9 HOH 214 1314 369  HOH HOH A . 
M 9 HOH 215 1315 394  HOH HOH A . 
M 9 HOH 216 1316 286  HOH HOH A . 
M 9 HOH 217 1317 386  HOH HOH A . 
M 9 HOH 218 1318 399  HOH HOH A . 
M 9 HOH 219 1319 283  HOH HOH A . 
M 9 HOH 220 1320 360  HOH HOH A . 
M 9 HOH 221 1321 19   HOH HOH A . 
M 9 HOH 222 1322 295  HOH HOH A . 
M 9 HOH 223 1323 297  HOH HOH A . 
M 9 HOH 224 1324 354  HOH HOH A . 
M 9 HOH 225 1325 384  HOH HOH A . 
M 9 HOH 226 1326 378  HOH HOH A . 
M 9 HOH 227 1327 363  HOH HOH A . 
M 9 HOH 228 1328 391  HOH HOH A . 
M 9 HOH 229 1329 314  HOH HOH A . 
M 9 HOH 230 1330 32   HOH HOH A . 
M 9 HOH 231 1331 366  HOH HOH A . 
M 9 HOH 232 1332 344  HOH HOH A . 
M 9 HOH 233 1333 67   HOH HOH A . 
M 9 HOH 234 1334 416  HOH HOH A . 
M 9 HOH 235 1335 20   HOH HOH A . 
M 9 HOH 236 1336 261  HOH HOH A . 
M 9 HOH 237 1337 334  HOH HOH A . 
M 9 HOH 238 1338 24   HOH HOH A . 
M 9 HOH 239 1339 299  HOH HOH A . 
M 9 HOH 240 1340 367  HOH HOH A . 
M 9 HOH 241 1341 388  HOH HOH A . 
M 9 HOH 242 1342 418  HOH HOH A . 
M 9 HOH 243 1343 361  HOH HOH A . 
M 9 HOH 244 1344 148  HOH HOH A . 
M 9 HOH 245 1345 57   HOH HOH A . 
M 9 HOH 246 1346 364  HOH HOH A . 
M 9 HOH 247 1347 356  HOH HOH A . 
M 9 HOH 248 1348 14   HOH HOH A . 
M 9 HOH 249 1349 284  HOH HOH A . 
M 9 HOH 250 1350 461  HOH HOH A . 
M 9 HOH 251 1351 352  HOH HOH A . 
M 9 HOH 252 1352 228  HOH HOH A . 
M 9 HOH 253 1353 380  HOH HOH A . 
M 9 HOH 254 1354 338  HOH HOH A . 
M 9 HOH 255 1355 117  HOH HOH A . 
M 9 HOH 256 1356 38   HOH HOH A . 
M 9 HOH 257 1357 127  HOH HOH A . 
M 9 HOH 258 1358 383  HOH HOH A . 
M 9 HOH 259 1359 375  HOH HOH A . 
M 9 HOH 260 1360 353  HOH HOH A . 
M 9 HOH 261 1361 305  HOH HOH A . 
M 9 HOH 262 1362 114  HOH HOH A . 
M 9 HOH 263 1363 362  HOH HOH A . 
M 9 HOH 264 1364 42   HOH HOH A . 
M 9 HOH 265 1365 371  HOH HOH A . 
M 9 HOH 266 1366 48   HOH HOH A . 
M 9 HOH 267 1367 282  HOH HOH A . 
M 9 HOH 268 1368 237  HOH HOH A . 
M 9 HOH 269 1369 372  HOH HOH A . 
M 9 HOH 270 1370 402  HOH HOH A . 
M 9 HOH 271 1371 335  HOH HOH A . 
M 9 HOH 272 1372 116  HOH HOH A . 
M 9 HOH 273 1373 97   HOH HOH A . 
M 9 HOH 274 1374 351  HOH HOH A . 
M 9 HOH 275 1375 459  HOH HOH A . 
M 9 HOH 276 1376 400  HOH HOH A . 
M 9 HOH 277 1377 4    HOH HOH A . 
M 9 HOH 278 1378 393  HOH HOH A . 
M 9 HOH 279 1379 124  HOH HOH A . 
M 9 HOH 280 1380 169  HOH HOH A . 
M 9 HOH 281 1381 403  HOH HOH A . 
M 9 HOH 282 1382 373  HOH HOH A . 
M 9 HOH 283 1383 68   HOH HOH A . 
M 9 HOH 284 1384 379  HOH HOH A . 
M 9 HOH 285 1385 40   HOH HOH A . 
M 9 HOH 286 1386 406  HOH HOH A . 
M 9 HOH 287 1387 291  HOH HOH A . 
M 9 HOH 288 1388 404  HOH HOH A . 
M 9 HOH 289 1389 390  HOH HOH A . 
M 9 HOH 290 1390 62   HOH HOH A . 
M 9 HOH 291 1391 118  HOH HOH A . 
M 9 HOH 292 1392 1    HOH HOH A . 
M 9 HOH 293 1393 56   HOH HOH A . 
M 9 HOH 294 1394 326  HOH HOH A . 
M 9 HOH 295 1395 374  HOH HOH A . 
M 9 HOH 296 1396 411  HOH HOH A . 
M 9 HOH 297 1397 349  HOH HOH A . 
M 9 HOH 298 1398 359  HOH HOH A . 
M 9 HOH 299 1399 80   HOH HOH A . 
M 9 HOH 300 1400 269  HOH HOH A . 
M 9 HOH 301 1401 181  HOH HOH A . 
M 9 HOH 302 1402 454  HOH HOH A . 
M 9 HOH 303 1403 128  HOH HOH A . 
M 9 HOH 304 1404 99   HOH HOH A . 
M 9 HOH 305 1405 412  HOH HOH A . 
M 9 HOH 306 1406 340  HOH HOH A . 
M 9 HOH 307 1407 146  HOH HOH A . 
M 9 HOH 308 1408 253  HOH HOH A . 
M 9 HOH 309 1409 138  HOH HOH A . 
M 9 HOH 310 1410 65   HOH HOH A . 
M 9 HOH 311 1411 444  HOH HOH A . 
M 9 HOH 312 1412 398  HOH HOH A . 
M 9 HOH 313 1413 409  HOH HOH A . 
M 9 HOH 314 1414 410  HOH HOH A . 
M 9 HOH 315 1415 131  HOH HOH A . 
M 9 HOH 316 1416 28   HOH HOH A . 
M 9 HOH 317 1417 376  HOH HOH A . 
M 9 HOH 318 1418 71   HOH HOH A . 
M 9 HOH 319 1419 422  HOH HOH A . 
M 9 HOH 320 1420 415  HOH HOH A . 
M 9 HOH 321 1421 18   HOH HOH A . 
M 9 HOH 322 1422 72   HOH HOH A . 
M 9 HOH 323 1423 200  HOH HOH A . 
M 9 HOH 324 1424 13   HOH HOH A . 
M 9 HOH 325 1425 132  HOH HOH A . 
M 9 HOH 326 1426 63   HOH HOH A . 
M 9 HOH 327 1427 54   HOH HOH A . 
M 9 HOH 328 1428 413  HOH HOH A . 
M 9 HOH 329 1429 147  HOH HOH A . 
M 9 HOH 330 1430 437  HOH HOH A . 
M 9 HOH 331 1431 98   HOH HOH A . 
M 9 HOH 332 1432 301  HOH HOH A . 
M 9 HOH 333 1433 154  HOH HOH A . 
M 9 HOH 334 1434 102  HOH HOH A . 
M 9 HOH 335 1435 41   HOH HOH A . 
M 9 HOH 336 1436 43   HOH HOH A . 
M 9 HOH 337 1437 88   HOH HOH A . 
M 9 HOH 338 1438 123  HOH HOH A . 
M 9 HOH 339 1439 382  HOH HOH A . 
M 9 HOH 340 1440 78   HOH HOH A . 
M 9 HOH 341 1441 439  HOH HOH A . 
M 9 HOH 342 1442 332  HOH HOH A . 
M 9 HOH 343 1443 457  HOH HOH A . 
M 9 HOH 344 1444 436  HOH HOH A . 
M 9 HOH 345 1445 59   HOH HOH A . 
M 9 HOH 346 1446 414  HOH HOH A . 
M 9 HOH 347 1447 430  HOH HOH A . 
M 9 HOH 348 1448 337  HOH HOH A . 
M 9 HOH 349 1449 431  HOH HOH A . 
M 9 HOH 350 1450 429  HOH HOH A . 
M 9 HOH 351 1451 425  HOH HOH A . 
M 9 HOH 352 1452 44   HOH HOH A . 
M 9 HOH 353 1453 456  HOH HOH A . 
M 9 HOH 354 1454 423  HOH HOH A . 
M 9 HOH 355 1455 428  HOH HOH A . 
M 9 HOH 356 1456 465  HOH HOH A . 
M 9 HOH 357 1457 208  HOH HOH A . 
M 9 HOH 358 1458 424  HOH HOH A . 
M 9 HOH 359 1459 61   HOH HOH A . 
M 9 HOH 360 1460 397  HOH HOH A . 
M 9 HOH 361 1461 452  HOH HOH A . 
M 9 HOH 362 1462 435  HOH HOH A . 
M 9 HOH 363 1463 53   HOH HOH A . 
M 9 HOH 364 1464 466  HOH HOH A . 
M 9 HOH 365 1465 426  HOH HOH A . 
M 9 HOH 366 1466 137  HOH HOH A . 
M 9 HOH 367 1467 103  HOH HOH A . 
M 9 HOH 368 1468 438  HOH HOH A . 
M 9 HOH 369 1469 8    HOH HOH A . 
M 9 HOH 370 1470 121  HOH HOH A . 
M 9 HOH 371 1471 443  HOH HOH A . 
M 9 HOH 372 1472 445  HOH HOH A . 
M 9 HOH 373 1473 55   HOH HOH A . 
M 9 HOH 374 1474 64   HOH HOH A . 
M 9 HOH 375 1475 455  HOH HOH A . 
M 9 HOH 376 1476 453  HOH HOH A . 
M 9 HOH 377 1477 449  HOH HOH A . 
M 9 HOH 378 1478 126  HOH HOH A . 
M 9 HOH 379 1479 130  HOH HOH A . 
M 9 HOH 380 1480 105  HOH HOH A . 
M 9 HOH 381 1481 441  HOH HOH A . 
M 9 HOH 382 1482 420  HOH HOH A . 
M 9 HOH 383 1483 447  HOH HOH A . 
M 9 HOH 384 1484 162  HOH HOH A . 
M 9 HOH 385 1485 168  HOH HOH A . 
M 9 HOH 386 1486 440  HOH HOH A . 
M 9 HOH 387 1487 448  HOH HOH A . 
M 9 HOH 388 1488 9    HOH HOH A . 
M 9 HOH 389 1489 135  HOH HOH A . 
M 9 HOH 390 1490 95   HOH HOH A . 
M 9 HOH 391 1491 17   HOH HOH A . 
M 9 HOH 392 1492 73   HOH HOH A . 
M 9 HOH 393 1493 450  HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A THR 344 ? CB  ? A THR 81 CB  
2 1 Y 1 A THR 344 ? OG1 ? A THR 81 OG1 
3 1 Y 1 A THR 344 ? CG2 ? A THR 81 CG2 
# 
loop_
_software.classification 
_software.name 
_software.version 
_software.citation_id 
_software.pdbx_ordinal 
_software.date 
_software.type 
_software.location 
_software.language 
refinement       REFMAC  5.8.0267 ? 1 ? ? ? ? 
'data scaling'   Aimless .        ? 2 ? ? ? ? 
phasing          PHASER  .        ? 3 ? ? ? ? 
'data reduction' XDS     .        ? 4 ? ? ? ? 
# 
_cell.entry_id           7I2J 
_cell.length_a           82.424 
_cell.length_b           116.066 
_cell.length_c           148.261 
_cell.angle_alpha        90.00 
_cell.angle_beta         90.00 
_cell.angle_gamma        90.00 
_cell.Z_PDB              8 
_cell.pdbx_unique_axis   ? 
# 
_symmetry.entry_id                         7I2J 
_symmetry.space_group_name_H-M             'I 2 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                23 
# 
_exptl.entry_id          7I2J 
_exptl.method            'X-RAY DIFFRACTION' 
_exptl.crystals_number   1 
# 
_exptl_crystal.id                    1 
_exptl_crystal.density_meas          ? 
_exptl_crystal.density_Matthews      2.40 
_exptl_crystal.density_percent_sol   48.74 
_exptl_crystal.description           ? 
_exptl_crystal.preparation           ? 
# 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.temp            293.15 
_exptl_crystal_grow.pdbx_details    '350 mM Magnesium chloride, 10% PEG 4000, 100 mM MES, pH 6.5' 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.pdbx_pH_range   ? 
# 
_diffrn.id                               1 
_diffrn.ambient_temp                     100 
_diffrn.crystal_id                       1 
_diffrn.ambient_temp_details             ? 
_diffrn.pdbx_serial_crystal_experiment   ? 
# 
_diffrn_detector.detector               PIXEL 
_diffrn_detector.type                   'DECTRIS EIGER2 XE 9M' 
_diffrn_detector.pdbx_collection_date   2023-12-02 
_diffrn_detector.diffrn_id              1 
_diffrn_detector.details                ? 
# 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.92124 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.diffrn_id                   1 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.type                        'DIAMOND BEAMLINE I04-1' 
_diffrn_source.pdbx_wavelength_list        0.92124 
_diffrn_source.pdbx_synchrotron_site       Diamond 
_diffrn_source.pdbx_synchrotron_beamline   I04-1 
_diffrn_source.pdbx_wavelength             ? 
# 
_reflns.entry_id                     7I2J 
_reflns.pdbx_diffrn_id               1 
_reflns.pdbx_ordinal                 1 
_reflns.d_resolution_low             72.04 
_reflns.d_resolution_high            1.98 
_reflns.number_obs                   49086 
_reflns.percent_possible_obs         98.6 
_reflns.pdbx_Rmerge_I_obs            0.161 
_reflns.pdbx_netI_over_sigmaI        10.5 
_reflns.pdbx_redundancy              10.5 
_reflns.pdbx_Rrim_I_all              0.170 
_reflns.pdbx_Rpim_I_all              0.052 
_reflns.pdbx_CC_half                 0.993 
_reflns.pdbx_number_measured_all     517164 
_reflns.pdbx_chi_squared             0.89 
_reflns.observed_criterion_sigma_I   ? 
_reflns.observed_criterion_sigma_F   ? 
_reflns.number_all                   ? 
_reflns.pdbx_Rsym_value              ? 
_reflns.B_iso_Wilson_estimate        ? 
_reflns.pdbx_CC_star                 ? 
# 
_reflns_shell.pdbx_diffrn_id              1 
_reflns_shell.pdbx_ordinal                1 
_reflns_shell.d_res_high                  1.98 
_reflns_shell.d_res_low                   2.08 
_reflns_shell.number_measured_all         74879 
_reflns_shell.number_unique_obs           7115 
_reflns_shell.Rmerge_I_obs                2.120 
_reflns_shell.pdbx_chi_squared            0.77 
_reflns_shell.pdbx_redundancy             10.5 
_reflns_shell.percent_possible_obs        99.2 
_reflns_shell.pdbx_netI_over_sigmaI_obs   1.4 
_reflns_shell.pdbx_Rrim_I_all             2.247 
_reflns_shell.pdbx_Rpim_I_all             0.718 
_reflns_shell.pdbx_CC_half                0.390 
_reflns_shell.percent_possible_all        ? 
_reflns_shell.pdbx_Rsym_value             ? 
_reflns_shell.meanI_over_sigI_obs         ? 
_reflns_shell.number_measured_obs         ? 
_reflns_shell.number_unique_all           ? 
_reflns_shell.pdbx_CC_star                ? 
# 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.entry_id                                 7I2J 
_refine.pdbx_diffrn_id                           1 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     45960 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             72.0 
_refine.ls_d_res_high                            1.98 
_refine.ls_percent_reflns_obs                    96.71 
_refine.ls_R_factor_obs                          0.18576 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       0.18348 
_refine.ls_R_factor_R_free                       0.22720 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 5.1 
_refine.ls_number_reflns_R_free                  2472 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               0.963 
_refine.correlation_coeff_Fo_to_Fc_free          0.941 
_refine.B_iso_mean                               60.643 
_refine.aniso_B[1][1]                            -3.59 
_refine.aniso_B[2][2]                            0.29 
_refine.aniso_B[3][3]                            3.30 
_refine.aniso_B[1][2]                            -0.00 
_refine.aniso_B[1][3]                            0.00 
_refine.aniso_B[2][3]                            -0.00 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_overall_ESU_R                       0.412 
_refine.pdbx_overall_ESU_R_Free                  0.210 
_refine.overall_SU_ML                            0.204 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             7.947 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.pdbx_number_atoms_protein        4668 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         58 
_refine_hist.number_atoms_solvent             393 
_refine_hist.number_atoms_total               5119 
_refine_hist.d_res_high                       1.98 
_refine_hist.d_res_low                        72.0 
# 
loop_
_refine_ls_restr.type 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.weight 
_refine_ls_restr.number 
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.pdbx_restraint_function 
r_bond_refined_d             0.007  0.015  ? 12263 'X-RAY DIFFRACTION' ? 
r_bond_other_d               0.001  0.015  ? 8764  'X-RAY DIFFRACTION' ? 
r_angle_refined_deg          1.434  1.648  ? 12548 'X-RAY DIFFRACTION' ? 
r_angle_other_deg            1.174  1.600  ? 20265 'X-RAY DIFFRACTION' ? 
r_dihedral_angle_1_deg       6.202  5.000  ? 1158  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_2_deg       29.729 20.496 ? 565   'X-RAY DIFFRACTION' ? 
r_dihedral_angle_3_deg       17.304 15.000 ? 1780  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_4_deg       16.232 15.000 ? 104   'X-RAY DIFFRACTION' ? 
r_chiral_restr               0.064  0.200  ? 1140  'X-RAY DIFFRACTION' ? 
r_gen_planes_refined         0.007  0.020  ? 10800 'X-RAY DIFFRACTION' ? 
r_gen_planes_other           0.001  0.020  ? 2336  'X-RAY DIFFRACTION' ? 
r_nbd_refined                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbd_other                  ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_refined              ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_other                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_refined        ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_other          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_refined          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_other            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_refined       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_other         ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_refined     ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_other       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_refined ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_other   ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_mcbond_it                  2.762  6.163  ? 5773  'X-RAY DIFFRACTION' ? 
r_mcbond_other               2.789  6.183  ? 5660  'X-RAY DIFFRACTION' ? 
r_mcangle_it                 5.000  8.717  ? 5586  'X-RAY DIFFRACTION' ? 
r_mcangle_other              5.001  8.718  ? 5583  'X-RAY DIFFRACTION' ? 
r_scbond_it                  2.953  6.946  ? 6490  'X-RAY DIFFRACTION' ? 
r_scbond_other               2.953  6.946  ? 6490  'X-RAY DIFFRACTION' ? 
r_scangle_it                 ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_scangle_other              5.071  9.785  ? 6963  'X-RAY DIFFRACTION' ? 
r_long_range_B_refined       8.241  63.991 ? 10664 'X-RAY DIFFRACTION' ? 
r_long_range_B_other         8.103  63.901 ? 10528 'X-RAY DIFFRACTION' ? 
r_rigid_bond_restr           ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_free            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_bonded          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.d_res_high                       1.976 
_refine_ls_shell.d_res_low                        2.028 
_refine_ls_shell.number_reflns_R_work             3147 
_refine_ls_shell.R_factor_R_work                  0.342 
_refine_ls_shell.percent_reflns_obs               92.27 
_refine_ls_shell.R_factor_R_free                  0.346 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.number_reflns_R_free             195 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.number_reflns_obs                ? 
# 
_struct.entry_id                  7I2J 
_struct.title                     
;Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z1269139261 (DNV2_NS5A-x0479)
;
_struct.pdbx_model_details        ? 
_struct.pdbx_CASP_flag            ? 
_struct.pdbx_model_type_details   ? 
# 
_struct_keywords.entry_id        7I2J 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
_struct_keywords.text            
;Diamond Light Source, I04-1, READDI, Dengue Virus, crystallographic fragment screening, PanDDA, XChemExplorer, cluster4x, VIRAL PROTEIN
;
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 4 ? 
H N N 5 ? 
I N N 5 ? 
J N N 6 ? 
K N N 7 ? 
L N N 8 ? 
M N N 9 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q91H74_9FLAV 
_struct_ref.pdbx_db_accession          Q91H74 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;GIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAMTD
TTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAREA
VEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLS
GVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRPTP
RGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGDDC
VVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQGAG
WSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPWME
DKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_struct_ref.pdbx_align_begin           2757 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              7I2J 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 3 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 637 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q91H74 
_struct_ref_seq.db_align_beg                  2757 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3391 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       266 
_struct_ref_seq.pdbx_auth_seq_align_end       900 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 7I2J GLY A 1 ? UNP Q91H74 ? ? 'expression tag' 264 1 
1 7I2J PRO A 2 ? UNP Q91H74 ? ? 'expression tag' 265 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 10  ? HIS A 25  ? ASN A 273 HIS A 288 1 ? 16 
HELX_P HELX_P2  AA2 ASN A 59  ? LEU A 65  ? ASN A 322 LEU A 328 1 ? 7  
HELX_P HELX_P3  AA3 THR A 66  ? ILE A 71  ? THR A 329 ILE A 334 5 ? 6  
HELX_P HELX_P4  AA4 ILE A 72  ? GLN A 77  ? ILE A 335 GLN A 340 1 ? 6  
HELX_P HELX_P5  AA5 MET A 78  ? MET A 80  ? MET A 341 MET A 343 5 ? 3  
HELX_P HELX_P6  AA6 LYS A 104 ? LYS A 124 ? LYS A 367 LYS A 387 1 ? 21 
HELX_P HELX_P7  AA7 THR A 132 ? ARG A 141 ? THR A 395 ARG A 404 1 ? 10 
HELX_P HELX_P8  AA8 SER A 158 ? VAL A 163 ? SER A 421 VAL A 426 1 ? 6  
HELX_P HELX_P9  AA9 ASP A 165 ? GLU A 181 ? ASP A 428 GLU A 444 1 ? 17 
HELX_P HELX_P10 AB1 TRP A 215 ? GLY A 227 ? TRP A 478 GLY A 490 1 ? 13 
HELX_P HELX_P11 AB2 GLY A 227 ? ASP A 232 ? GLY A 490 ASP A 495 1 ? 6  
HELX_P HELX_P12 AB3 SER A 236 ? LEU A 241 ? SER A 499 LEU A 504 1 ? 6  
HELX_P HELX_P13 AB4 GLY A 248 ? LYS A 261 ? GLY A 511 LYS A 524 1 ? 14 
HELX_P HELX_P14 AB5 GLY A 274 ? ILE A 279 ? GLY A 537 ILE A 542 5 ? 6  
HELX_P HELX_P15 AB6 THR A 280 ? MET A 289 ? THR A 543 MET A 552 1 ? 10 
HELX_P HELX_P16 AB7 VAL A 290 ? MET A 294 ? VAL A 553 MET A 557 5 ? 5  
HELX_P HELX_P17 AB8 GLU A 295 ? THR A 309 ? GLU A 558 THR A 572 1 ? 15 
HELX_P HELX_P18 AB9 GLY A 339 ? GLU A 363 ? GLY A 602 GLU A 626 1 ? 25 
HELX_P HELX_P19 AC1 VAL A 374 ? SER A 393 ? VAL A 637 SER A 656 1 ? 20 
HELX_P HELX_P20 AC2 ASP A 408 ? ALA A 414 ? ASP A 671 ALA A 677 5 ? 7  
HELX_P HELX_P21 AC3 LEU A 415 ? MET A 421 ? LEU A 678 MET A 684 1 ? 7  
HELX_P HELX_P22 AC4 ASP A 439 ? VAL A 443 ? ASP A 702 VAL A 706 5 ? 5  
HELX_P HELX_P23 AC5 ASN A 467 ? ARG A 476 ? ASN A 730 ARG A 739 1 ? 10 
HELX_P HELX_P24 AC6 SER A 484 ? TYR A 503 ? SER A 747 TYR A 766 1 ? 20 
HELX_P HELX_P25 AC7 ARG A 506 ? VAL A 520 ? ARG A 769 VAL A 783 1 ? 15 
HELX_P HELX_P26 AC8 ASP A 545 ? ILE A 555 ? ASP A 808 ILE A 818 1 ? 11 
HELX_P HELX_P27 AC9 SER A 569 ? ILE A 573 ? SER A 832 ILE A 836 5 ? 5  
HELX_P HELX_P28 AD1 GLY A 577 ? CYS A 584 ? GLY A 840 CYS A 847 1 ? 8  
HELX_P HELX_P29 AD2 LEU A 590 ? ASN A 599 ? LEU A 853 ASN A 862 1 ? 10 
HELX_P HELX_P30 AD3 ASN A 599 ? GLY A 612 ? ASN A 862 GLY A 875 1 ? 14 
HELX_P HELX_P31 AD4 TYR A 619 ? SER A 622 ? TYR A 882 SER A 885 5 ? 4  
HELX_P HELX_P32 AD5 MET A 623 ? ARG A 628 ? MET A 886 ARG A 891 1 ? 6  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A GLU 175 OE1 ? ? ? 1_555 C ZN . ZN ? ? A GLU 438 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.348 ? ? 
metalc2 metalc ? ? A HIS 179 NE2 ? ? ? 1_555 C ZN . ZN ? ? A HIS 442 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.116 ? ? 
metalc3 metalc ? ? A CYS 184 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 447 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.192 ? ? 
metalc4 metalc ? ? A CYS 187 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 450 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.679 ? ? 
metalc5 metalc ? ? A HIS 449 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 712 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.117 ? ? 
metalc6 metalc ? ? A HIS 451 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 714 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.057 ? ? 
metalc7 metalc ? ? A CYS 465 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 728 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.364 ? ? 
metalc8 metalc ? ? A CYS 584 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 847 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.328 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 NE2 ? A HIS 179 ? A HIS 442 ? 1_555 116.1 ? 
2  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 118.9 ? 
3  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 118.5 ? 
4  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 73.0  ? 
5  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 112.6 ? 
6  SG  ? A CYS 184 ? A CYS 447 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 108.0 ? 
7  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 99.7  ? 
8  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 107.3 ? 
9  NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 108.1 ? 
10 NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 104.4 ? 
11 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 119.1 ? 
12 SG  ? A CYS 465 ? A CYS 728 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 116.2 ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 41  ? GLU A 47  ? ALA A 304 GLU A 310 
AA1 2 VAL A 326 ? ARG A 332 ? VAL A 589 ARG A 595 
AA1 3 LYS A 313 ? ARG A 319 ? LYS A 576 ARG A 582 
AA1 4 TYR A 189 ? MET A 191 ? TYR A 452 MET A 454 
AA1 5 TRP A 212 ? TYR A 213 ? TRP A 475 TYR A 476 
AA2 1 SER A 56  ? VAL A 58  ? SER A 319 VAL A 321 
AA2 2 ILE A 477 ? GLN A 479 ? ILE A 740 GLN A 742 
AA3 1 MET A 395 ? SER A 398 ? MET A 658 SER A 661 
AA3 2 ASP A 401 ? VAL A 404 ? ASP A 664 VAL A 667 
AA4 1 HIS A 449 ? ILE A 454 ? HIS A 712 ILE A 717 
AA4 2 VAL A 460 ? CYS A 465 ? VAL A 723 CYS A 728 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ALA A 41  ? N ALA A 304 O SER A 331 ? O SER A 594 
AA1 2 3 O ASP A 328 ? O ASP A 591 N VAL A 317 ? N VAL A 580 
AA1 3 4 O ARG A 316 ? O ARG A 579 N TYR A 189 ? N TYR A 452 
AA1 4 5 N ASN A 190 ? N ASN A 453 O TYR A 213 ? O TYR A 476 
AA2 1 2 N MET A 57  ? N MET A 320 O SER A 478 ? O SER A 741 
AA3 1 2 N SER A 398 ? N SER A 661 O ASP A 401 ? O ASP A 664 
AA4 1 2 N LEU A 453 ? N LEU A 716 O LEU A 461 ? O LEU A 724 
# 
_pdbx_entry_details.entry_id                   7I2J 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 OD1 A ASP 534 ? ? O4 A PO4 1007 ? ? 1.79 
2 1 OD1 A ASP 664 ? ? O4 A PO4 1007 ? ? 1.98 
# 
loop_
_pdbx_validate_symm_contact.id 
_pdbx_validate_symm_contact.PDB_model_num 
_pdbx_validate_symm_contact.auth_atom_id_1 
_pdbx_validate_symm_contact.auth_asym_id_1 
_pdbx_validate_symm_contact.auth_comp_id_1 
_pdbx_validate_symm_contact.auth_seq_id_1 
_pdbx_validate_symm_contact.PDB_ins_code_1 
_pdbx_validate_symm_contact.label_alt_id_1 
_pdbx_validate_symm_contact.site_symmetry_1 
_pdbx_validate_symm_contact.auth_atom_id_2 
_pdbx_validate_symm_contact.auth_asym_id_2 
_pdbx_validate_symm_contact.auth_comp_id_2 
_pdbx_validate_symm_contact.auth_seq_id_2 
_pdbx_validate_symm_contact.PDB_ins_code_2 
_pdbx_validate_symm_contact.label_alt_id_2 
_pdbx_validate_symm_contact.site_symmetry_2 
_pdbx_validate_symm_contact.dist 
1 1 O A HOH 1147 ? ? 1_555 O A HOH 1147 ? ? 2_445 1.44 
2 1 O A HOH 1331 ? ? 1_555 O A HOH 1331 ? ? 4_545 2.10 
3 1 O A HOH 1349 ? ? 1_555 O A HOH 1414 ? ? 2_545 2.12 
# 
_pdbx_validate_rmsd_bond.id                        1 
_pdbx_validate_rmsd_bond.PDB_model_num             1 
_pdbx_validate_rmsd_bond.auth_atom_id_1            CD 
_pdbx_validate_rmsd_bond.auth_asym_id_1            A 
_pdbx_validate_rmsd_bond.auth_comp_id_1            GLU 
_pdbx_validate_rmsd_bond.auth_seq_id_1             510 
_pdbx_validate_rmsd_bond.PDB_ins_code_1            ? 
_pdbx_validate_rmsd_bond.label_alt_id_1            ? 
_pdbx_validate_rmsd_bond.auth_atom_id_2            OE2 
_pdbx_validate_rmsd_bond.auth_asym_id_2            A 
_pdbx_validate_rmsd_bond.auth_comp_id_2            GLU 
_pdbx_validate_rmsd_bond.auth_seq_id_2             510 
_pdbx_validate_rmsd_bond.PDB_ins_code_2            ? 
_pdbx_validate_rmsd_bond.label_alt_id_2            ? 
_pdbx_validate_rmsd_bond.bond_value                1.337 
_pdbx_validate_rmsd_bond.bond_target_value         1.252 
_pdbx_validate_rmsd_bond.bond_deviation            0.085 
_pdbx_validate_rmsd_bond.bond_standard_deviation   0.011 
_pdbx_validate_rmsd_bond.linker_flag               N 
# 
loop_
_pdbx_validate_rmsd_angle.id 
_pdbx_validate_rmsd_angle.PDB_model_num 
_pdbx_validate_rmsd_angle.auth_atom_id_1 
_pdbx_validate_rmsd_angle.auth_asym_id_1 
_pdbx_validate_rmsd_angle.auth_comp_id_1 
_pdbx_validate_rmsd_angle.auth_seq_id_1 
_pdbx_validate_rmsd_angle.PDB_ins_code_1 
_pdbx_validate_rmsd_angle.label_alt_id_1 
_pdbx_validate_rmsd_angle.auth_atom_id_2 
_pdbx_validate_rmsd_angle.auth_asym_id_2 
_pdbx_validate_rmsd_angle.auth_comp_id_2 
_pdbx_validate_rmsd_angle.auth_seq_id_2 
_pdbx_validate_rmsd_angle.PDB_ins_code_2 
_pdbx_validate_rmsd_angle.label_alt_id_2 
_pdbx_validate_rmsd_angle.auth_atom_id_3 
_pdbx_validate_rmsd_angle.auth_asym_id_3 
_pdbx_validate_rmsd_angle.auth_comp_id_3 
_pdbx_validate_rmsd_angle.auth_seq_id_3 
_pdbx_validate_rmsd_angle.PDB_ins_code_3 
_pdbx_validate_rmsd_angle.label_alt_id_3 
_pdbx_validate_rmsd_angle.angle_value 
_pdbx_validate_rmsd_angle.angle_target_value 
_pdbx_validate_rmsd_angle.angle_deviation 
_pdbx_validate_rmsd_angle.angle_standard_deviation 
_pdbx_validate_rmsd_angle.linker_flag 
1 1 NE A ARG 621 ? ? CZ A ARG 621 ? ? NH1 A ARG 621 ? ? 123.45 120.30 3.15   0.50 N 
2 1 NE A ARG 621 ? ? CZ A ARG 621 ? ? NH2 A ARG 621 ? ? 117.22 120.30 -3.08  0.50 N 
3 1 CG A ARG 657 ? ? CD A ARG 657 ? ? NE  A ARG 657 ? ? 98.69  111.80 -13.11 2.10 N 
4 1 NE A ARG 815 ? ? CZ A ARG 815 ? ? NH2 A ARG 815 ? ? 116.80 120.30 -3.50  0.50 N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASP A 297 ? ? -98.70  44.60  
2  1 ASP A 360 ? ? -91.20  56.96  
3  1 SER A 405 ? ? -146.09 34.22  
4  1 ASN A 406 ? ? 67.14   103.23 
5  1 ALA A 407 ? ? -160.18 49.01  
6  1 GLU A 427 ? ? -102.91 48.42  
7  1 ASP A 428 ? ? -164.86 108.15 
8  1 CYS A 450 ? ? -115.14 72.52  
9  1 LEU A 504 ? ? 73.06   -36.84 
10 1 GLN A 598 ? ? 79.88   164.06 
11 1 HIS A 801 ? A -100.59 68.52  
12 1 HIS A 801 ? B -100.04 66.42  
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A MES 1003 ? D MES . 
2 1 A HOH 1151 ? M HOH . 
3 1 A HOH 1247 ? M HOH . 
4 1 A HOH 1442 ? M HOH . 
5 1 A HOH 1468 ? M HOH . 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 1492 ? 6.24 . 
2 1 O ? A HOH 1493 ? 6.44 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 264 ? A GLY 1   
2  1 Y 1 A PRO 265 ? A PRO 2   
3  1 Y 1 A GLY 266 ? A GLY 3   
4  1 Y 1 A ILE 267 ? A ILE 4   
5  1 Y 1 A GLU 268 ? A GLU 5   
6  1 Y 1 A SER 269 ? A SER 6   
7  1 Y 1 A GLU 270 ? A GLU 7   
8  1 Y 1 A THR 271 ? A THR 8   
9  1 Y 1 A PRO 272 ? A PRO 9   
10 1 Y 1 A GLN 313 ? A GLN 50  
11 1 Y 1 A THR 314 ? A THR 51  
12 1 Y 1 A GLY 315 ? A GLY 52  
13 1 Y 1 A SER 316 ? A SER 53  
14 1 Y 1 A ALA 317 ? A ALA 54  
15 1 Y 1 A ASP 345 ? A ASP 82  
16 1 Y 1 A THR 346 ? A THR 83  
17 1 Y 1 A THR 347 ? A THR 84  
18 1 Y 1 A PRO 348 ? A PRO 85  
19 1 Y 1 A PHE 349 ? A PHE 86  
20 1 Y 1 A GLY 350 ? A GLY 87  
21 1 Y 1 A GLN 351 ? A GLN 88  
22 1 Y 1 A GLN 352 ? A GLN 89  
23 1 Y 1 A ARG 353 ? A ARG 90  
24 1 Y 1 A VAL 354 ? A VAL 91  
25 1 Y 1 A PHE 355 ? A PHE 92  
26 1 Y 1 A PHE 413 ? A PHE 150 
27 1 Y 1 A THR 414 ? A THR 151 
28 1 Y 1 A ASP 415 ? A ASP 152 
29 1 Y 1 A GLU 416 ? A GLU 153 
30 1 Y 1 A ASN 417 ? A ASN 154 
31 1 Y 1 A LYS 418 ? A LYS 155 
32 1 Y 1 A GLY 456 ? A GLY 193 
33 1 Y 1 A LYS 457 ? A LYS 194 
34 1 Y 1 A ARG 458 ? A ARG 195 
35 1 Y 1 A GLU 459 ? A GLU 196 
36 1 Y 1 A LYS 460 ? A LYS 197 
37 1 Y 1 A LYS 461 ? A LYS 198 
38 1 Y 1 A LEU 462 ? A LEU 199 
39 1 Y 1 A GLY 463 ? A GLY 200 
40 1 Y 1 A GLU 464 ? A GLU 201 
41 1 Y 1 A PHE 465 ? A PHE 202 
42 1 Y 1 A GLY 466 ? A GLY 203 
43 1 Y 1 A LYS 467 ? A LYS 204 
44 1 Y 1 A ALA 468 ? A ALA 205 
45 1 Y 1 A LYS 469 ? A LYS 206 
46 1 Y 1 A GLY 470 ? A GLY 207 
47 1 Y 1 A SER 471 ? A SER 208 
48 1 Y 1 A ARG 472 ? A ARG 209 
49 1 Y 1 A PRO 585 ? A PRO 322 
50 1 Y 1 A ARG 586 ? A ARG 323 
51 1 Y 1 A GLY 587 ? A GLY 324 
52 1 Y 1 A THR 793 ? A THR 530 
53 1 Y 1 A THR 794 ? A THR 531 
54 1 Y 1 A TRP 795 ? A TRP 532 
55 1 Y 1 A SER 796 ? A SER 533 
56 1 Y 1 A ILE 797 ? A ILE 534 
57 1 Y 1 A HIS 798 ? A HIS 535 
58 1 Y 1 A GLU 892 ? A GLU 629 
59 1 Y 1 A GLU 893 ? A GLU 630 
60 1 Y 1 A GLU 894 ? A GLU 631 
61 1 Y 1 A GLU 895 ? A GLU 632 
62 1 Y 1 A ALA 896 ? A ALA 633 
63 1 Y 1 A GLY 897 ? A GLY 634 
64 1 Y 1 A VAL 898 ? A VAL 635 
65 1 Y 1 A LEU 899 ? A LEU 636 
66 1 Y 1 A TRP 900 ? A TRP 637 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CL  CL   CL N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
DMS S    S  N N 89  
DMS O    O  N N 90  
DMS C1   C  N N 91  
DMS C2   C  N N 92  
DMS H11  H  N N 93  
DMS H12  H  N N 94  
DMS H13  H  N N 95  
DMS H21  H  N N 96  
DMS H22  H  N N 97  
DMS H23  H  N N 98  
GLN N    N  N N 99  
GLN CA   C  N S 100 
GLN C    C  N N 101 
GLN O    O  N N 102 
GLN CB   C  N N 103 
GLN CG   C  N N 104 
GLN CD   C  N N 105 
GLN OE1  O  N N 106 
GLN NE2  N  N N 107 
GLN OXT  O  N N 108 
GLN H    H  N N 109 
GLN H2   H  N N 110 
GLN HA   H  N N 111 
GLN HB2  H  N N 112 
GLN HB3  H  N N 113 
GLN HG2  H  N N 114 
GLN HG3  H  N N 115 
GLN HE21 H  N N 116 
GLN HE22 H  N N 117 
GLN HXT  H  N N 118 
GLU N    N  N N 119 
GLU CA   C  N S 120 
GLU C    C  N N 121 
GLU O    O  N N 122 
GLU CB   C  N N 123 
GLU CG   C  N N 124 
GLU CD   C  N N 125 
GLU OE1  O  N N 126 
GLU OE2  O  N N 127 
GLU OXT  O  N N 128 
GLU H    H  N N 129 
GLU H2   H  N N 130 
GLU HA   H  N N 131 
GLU HB2  H  N N 132 
GLU HB3  H  N N 133 
GLU HG2  H  N N 134 
GLU HG3  H  N N 135 
GLU HE2  H  N N 136 
GLU HXT  H  N N 137 
GLY N    N  N N 138 
GLY CA   C  N N 139 
GLY C    C  N N 140 
GLY O    O  N N 141 
GLY OXT  O  N N 142 
GLY H    H  N N 143 
GLY H2   H  N N 144 
GLY HA2  H  N N 145 
GLY HA3  H  N N 146 
GLY HXT  H  N N 147 
HIS N    N  N N 148 
HIS CA   C  N S 149 
HIS C    C  N N 150 
HIS O    O  N N 151 
HIS CB   C  N N 152 
HIS CG   C  Y N 153 
HIS ND1  N  Y N 154 
HIS CD2  C  Y N 155 
HIS CE1  C  Y N 156 
HIS NE2  N  Y N 157 
HIS OXT  O  N N 158 
HIS H    H  N N 159 
HIS H2   H  N N 160 
HIS HA   H  N N 161 
HIS HB2  H  N N 162 
HIS HB3  H  N N 163 
HIS HD1  H  N N 164 
HIS HD2  H  N N 165 
HIS HE1  H  N N 166 
HIS HE2  H  N N 167 
HIS HXT  H  N N 168 
HOH O    O  N N 169 
HOH H1   H  N N 170 
HOH H2   H  N N 171 
ILE N    N  N N 172 
ILE CA   C  N S 173 
ILE C    C  N N 174 
ILE O    O  N N 175 
ILE CB   C  N S 176 
ILE CG1  C  N N 177 
ILE CG2  C  N N 178 
ILE CD1  C  N N 179 
ILE OXT  O  N N 180 
ILE H    H  N N 181 
ILE H2   H  N N 182 
ILE HA   H  N N 183 
ILE HB   H  N N 184 
ILE HG12 H  N N 185 
ILE HG13 H  N N 186 
ILE HG21 H  N N 187 
ILE HG22 H  N N 188 
ILE HG23 H  N N 189 
ILE HD11 H  N N 190 
ILE HD12 H  N N 191 
ILE HD13 H  N N 192 
ILE HXT  H  N N 193 
LEU N    N  N N 194 
LEU CA   C  N S 195 
LEU C    C  N N 196 
LEU O    O  N N 197 
LEU CB   C  N N 198 
LEU CG   C  N N 199 
LEU CD1  C  N N 200 
LEU CD2  C  N N 201 
LEU OXT  O  N N 202 
LEU H    H  N N 203 
LEU H2   H  N N 204 
LEU HA   H  N N 205 
LEU HB2  H  N N 206 
LEU HB3  H  N N 207 
LEU HG   H  N N 208 
LEU HD11 H  N N 209 
LEU HD12 H  N N 210 
LEU HD13 H  N N 211 
LEU HD21 H  N N 212 
LEU HD22 H  N N 213 
LEU HD23 H  N N 214 
LEU HXT  H  N N 215 
LYS N    N  N N 216 
LYS CA   C  N S 217 
LYS C    C  N N 218 
LYS O    O  N N 219 
LYS CB   C  N N 220 
LYS CG   C  N N 221 
LYS CD   C  N N 222 
LYS CE   C  N N 223 
LYS NZ   N  N N 224 
LYS OXT  O  N N 225 
LYS H    H  N N 226 
LYS H2   H  N N 227 
LYS HA   H  N N 228 
LYS HB2  H  N N 229 
LYS HB3  H  N N 230 
LYS HG2  H  N N 231 
LYS HG3  H  N N 232 
LYS HD2  H  N N 233 
LYS HD3  H  N N 234 
LYS HE2  H  N N 235 
LYS HE3  H  N N 236 
LYS HZ1  H  N N 237 
LYS HZ2  H  N N 238 
LYS HZ3  H  N N 239 
LYS HXT  H  N N 240 
MES O1   O  N N 241 
MES C2   C  N N 242 
MES C3   C  N N 243 
MES N4   N  N N 244 
MES C5   C  N N 245 
MES C6   C  N N 246 
MES C7   C  N N 247 
MES C8   C  N N 248 
MES S    S  N N 249 
MES O1S  O  N N 250 
MES O2S  O  N N 251 
MES O3S  O  N N 252 
MES H21  H  N N 253 
MES H22  H  N N 254 
MES H31  H  N N 255 
MES H32  H  N N 256 
MES HN4  H  N N 257 
MES H51  H  N N 258 
MES H52  H  N N 259 
MES H61  H  N N 260 
MES H62  H  N N 261 
MES H71  H  N N 262 
MES H72  H  N N 263 
MES H81  H  N N 264 
MES H82  H  N N 265 
MET N    N  N N 266 
MET CA   C  N S 267 
MET C    C  N N 268 
MET O    O  N N 269 
MET CB   C  N N 270 
MET CG   C  N N 271 
MET SD   S  N N 272 
MET CE   C  N N 273 
MET OXT  O  N N 274 
MET H    H  N N 275 
MET H2   H  N N 276 
MET HA   H  N N 277 
MET HB2  H  N N 278 
MET HB3  H  N N 279 
MET HG2  H  N N 280 
MET HG3  H  N N 281 
MET HE1  H  N N 282 
MET HE2  H  N N 283 
MET HE3  H  N N 284 
MET HXT  H  N N 285 
O3D N1   N  N N 286 
O3D C4   C  Y N 287 
O3D C5   C  Y N 288 
O3D C6   C  Y N 289 
O3D C7   C  Y N 290 
O3D C8   C  N N 291 
O3D C1   C  N N 292 
O3D C2   C  N N 293 
O3D C3   C  N N 294 
O3D C9   C  N N 295 
O3D O1   O  N N 296 
O3D O2   O  N N 297 
O3D O3   O  Y N 298 
O3D S1   S  N N 299 
O3D H2   H  N N 300 
O3D H3   H  N N 301 
O3D H4   H  N N 302 
O3D H5   H  N N 303 
O3D H6   H  N N 304 
O3D H7   H  N N 305 
O3D H8   H  N N 306 
O3D H9   H  N N 307 
O3D H10  H  N N 308 
O3D H11  H  N N 309 
O3D H12  H  N N 310 
O3D H13  H  N N 311 
O3D H14  H  N N 312 
PEG C1   C  N N 313 
PEG O1   O  N N 314 
PEG C2   C  N N 315 
PEG O2   O  N N 316 
PEG C3   C  N N 317 
PEG C4   C  N N 318 
PEG O4   O  N N 319 
PEG H11  H  N N 320 
PEG H12  H  N N 321 
PEG HO1  H  N N 322 
PEG H21  H  N N 323 
PEG H22  H  N N 324 
PEG H31  H  N N 325 
PEG H32  H  N N 326 
PEG H41  H  N N 327 
PEG H42  H  N N 328 
PEG HO4  H  N N 329 
PHE N    N  N N 330 
PHE CA   C  N S 331 
PHE C    C  N N 332 
PHE O    O  N N 333 
PHE CB   C  N N 334 
PHE CG   C  Y N 335 
PHE CD1  C  Y N 336 
PHE CD2  C  Y N 337 
PHE CE1  C  Y N 338 
PHE CE2  C  Y N 339 
PHE CZ   C  Y N 340 
PHE OXT  O  N N 341 
PHE H    H  N N 342 
PHE H2   H  N N 343 
PHE HA   H  N N 344 
PHE HB2  H  N N 345 
PHE HB3  H  N N 346 
PHE HD1  H  N N 347 
PHE HD2  H  N N 348 
PHE HE1  H  N N 349 
PHE HE2  H  N N 350 
PHE HZ   H  N N 351 
PHE HXT  H  N N 352 
PO4 P    P  N N 353 
PO4 O1   O  N N 354 
PO4 O2   O  N N 355 
PO4 O3   O  N N 356 
PO4 O4   O  N N 357 
PRO N    N  N N 358 
PRO CA   C  N S 359 
PRO C    C  N N 360 
PRO O    O  N N 361 
PRO CB   C  N N 362 
PRO CG   C  N N 363 
PRO CD   C  N N 364 
PRO OXT  O  N N 365 
PRO H    H  N N 366 
PRO HA   H  N N 367 
PRO HB2  H  N N 368 
PRO HB3  H  N N 369 
PRO HG2  H  N N 370 
PRO HG3  H  N N 371 
PRO HD2  H  N N 372 
PRO HD3  H  N N 373 
PRO HXT  H  N N 374 
SER N    N  N N 375 
SER CA   C  N S 376 
SER C    C  N N 377 
SER O    O  N N 378 
SER CB   C  N N 379 
SER OG   O  N N 380 
SER OXT  O  N N 381 
SER H    H  N N 382 
SER H2   H  N N 383 
SER HA   H  N N 384 
SER HB2  H  N N 385 
SER HB3  H  N N 386 
SER HG   H  N N 387 
SER HXT  H  N N 388 
THR N    N  N N 389 
THR CA   C  N S 390 
THR C    C  N N 391 
THR O    O  N N 392 
THR CB   C  N R 393 
THR OG1  O  N N 394 
THR CG2  C  N N 395 
THR OXT  O  N N 396 
THR H    H  N N 397 
THR H2   H  N N 398 
THR HA   H  N N 399 
THR HB   H  N N 400 
THR HG1  H  N N 401 
THR HG21 H  N N 402 
THR HG22 H  N N 403 
THR HG23 H  N N 404 
THR HXT  H  N N 405 
TRP N    N  N N 406 
TRP CA   C  N S 407 
TRP C    C  N N 408 
TRP O    O  N N 409 
TRP CB   C  N N 410 
TRP CG   C  Y N 411 
TRP CD1  C  Y N 412 
TRP CD2  C  Y N 413 
TRP NE1  N  Y N 414 
TRP CE2  C  Y N 415 
TRP CE3  C  Y N 416 
TRP CZ2  C  Y N 417 
TRP CZ3  C  Y N 418 
TRP CH2  C  Y N 419 
TRP OXT  O  N N 420 
TRP H    H  N N 421 
TRP H2   H  N N 422 
TRP HA   H  N N 423 
TRP HB2  H  N N 424 
TRP HB3  H  N N 425 
TRP HD1  H  N N 426 
TRP HE1  H  N N 427 
TRP HE3  H  N N 428 
TRP HZ2  H  N N 429 
TRP HZ3  H  N N 430 
TRP HH2  H  N N 431 
TRP HXT  H  N N 432 
TYR N    N  N N 433 
TYR CA   C  N S 434 
TYR C    C  N N 435 
TYR O    O  N N 436 
TYR CB   C  N N 437 
TYR CG   C  Y N 438 
TYR CD1  C  Y N 439 
TYR CD2  C  Y N 440 
TYR CE1  C  Y N 441 
TYR CE2  C  Y N 442 
TYR CZ   C  Y N 443 
TYR OH   O  N N 444 
TYR OXT  O  N N 445 
TYR H    H  N N 446 
TYR H2   H  N N 447 
TYR HA   H  N N 448 
TYR HB2  H  N N 449 
TYR HB3  H  N N 450 
TYR HD1  H  N N 451 
TYR HD2  H  N N 452 
TYR HE1  H  N N 453 
TYR HE2  H  N N 454 
TYR HH   H  N N 455 
TYR HXT  H  N N 456 
VAL N    N  N N 457 
VAL CA   C  N S 458 
VAL C    C  N N 459 
VAL O    O  N N 460 
VAL CB   C  N N 461 
VAL CG1  C  N N 462 
VAL CG2  C  N N 463 
VAL OXT  O  N N 464 
VAL H    H  N N 465 
VAL H2   H  N N 466 
VAL HA   H  N N 467 
VAL HB   H  N N 468 
VAL HG11 H  N N 469 
VAL HG12 H  N N 470 
VAL HG13 H  N N 471 
VAL HG21 H  N N 472 
VAL HG22 H  N N 473 
VAL HG23 H  N N 474 
VAL HXT  H  N N 475 
ZN  ZN   ZN N N 476 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
DMS S   O    doub N N 83  
DMS S   C1   sing N N 84  
DMS S   C2   sing N N 85  
DMS C1  H11  sing N N 86  
DMS C1  H12  sing N N 87  
DMS C1  H13  sing N N 88  
DMS C2  H21  sing N N 89  
DMS C2  H22  sing N N 90  
DMS C2  H23  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
HIS N   CA   sing N N 138 
HIS N   H    sing N N 139 
HIS N   H2   sing N N 140 
HIS CA  C    sing N N 141 
HIS CA  CB   sing N N 142 
HIS CA  HA   sing N N 143 
HIS C   O    doub N N 144 
HIS C   OXT  sing N N 145 
HIS CB  CG   sing N N 146 
HIS CB  HB2  sing N N 147 
HIS CB  HB3  sing N N 148 
HIS CG  ND1  sing Y N 149 
HIS CG  CD2  doub Y N 150 
HIS ND1 CE1  doub Y N 151 
HIS ND1 HD1  sing N N 152 
HIS CD2 NE2  sing Y N 153 
HIS CD2 HD2  sing N N 154 
HIS CE1 NE2  sing Y N 155 
HIS CE1 HE1  sing N N 156 
HIS NE2 HE2  sing N N 157 
HIS OXT HXT  sing N N 158 
HOH O   H1   sing N N 159 
HOH O   H2   sing N N 160 
ILE N   CA   sing N N 161 
ILE N   H    sing N N 162 
ILE N   H2   sing N N 163 
ILE CA  C    sing N N 164 
ILE CA  CB   sing N N 165 
ILE CA  HA   sing N N 166 
ILE C   O    doub N N 167 
ILE C   OXT  sing N N 168 
ILE CB  CG1  sing N N 169 
ILE CB  CG2  sing N N 170 
ILE CB  HB   sing N N 171 
ILE CG1 CD1  sing N N 172 
ILE CG1 HG12 sing N N 173 
ILE CG1 HG13 sing N N 174 
ILE CG2 HG21 sing N N 175 
ILE CG2 HG22 sing N N 176 
ILE CG2 HG23 sing N N 177 
ILE CD1 HD11 sing N N 178 
ILE CD1 HD12 sing N N 179 
ILE CD1 HD13 sing N N 180 
ILE OXT HXT  sing N N 181 
LEU N   CA   sing N N 182 
LEU N   H    sing N N 183 
LEU N   H2   sing N N 184 
LEU CA  C    sing N N 185 
LEU CA  CB   sing N N 186 
LEU CA  HA   sing N N 187 
LEU C   O    doub N N 188 
LEU C   OXT  sing N N 189 
LEU CB  CG   sing N N 190 
LEU CB  HB2  sing N N 191 
LEU CB  HB3  sing N N 192 
LEU CG  CD1  sing N N 193 
LEU CG  CD2  sing N N 194 
LEU CG  HG   sing N N 195 
LEU CD1 HD11 sing N N 196 
LEU CD1 HD12 sing N N 197 
LEU CD1 HD13 sing N N 198 
LEU CD2 HD21 sing N N 199 
LEU CD2 HD22 sing N N 200 
LEU CD2 HD23 sing N N 201 
LEU OXT HXT  sing N N 202 
LYS N   CA   sing N N 203 
LYS N   H    sing N N 204 
LYS N   H2   sing N N 205 
LYS CA  C    sing N N 206 
LYS CA  CB   sing N N 207 
LYS CA  HA   sing N N 208 
LYS C   O    doub N N 209 
LYS C   OXT  sing N N 210 
LYS CB  CG   sing N N 211 
LYS CB  HB2  sing N N 212 
LYS CB  HB3  sing N N 213 
LYS CG  CD   sing N N 214 
LYS CG  HG2  sing N N 215 
LYS CG  HG3  sing N N 216 
LYS CD  CE   sing N N 217 
LYS CD  HD2  sing N N 218 
LYS CD  HD3  sing N N 219 
LYS CE  NZ   sing N N 220 
LYS CE  HE2  sing N N 221 
LYS CE  HE3  sing N N 222 
LYS NZ  HZ1  sing N N 223 
LYS NZ  HZ2  sing N N 224 
LYS NZ  HZ3  sing N N 225 
LYS OXT HXT  sing N N 226 
MES O1  C2   sing N N 227 
MES O1  C6   sing N N 228 
MES C2  C3   sing N N 229 
MES C2  H21  sing N N 230 
MES C2  H22  sing N N 231 
MES C3  N4   sing N N 232 
MES C3  H31  sing N N 233 
MES C3  H32  sing N N 234 
MES N4  C5   sing N N 235 
MES N4  C7   sing N N 236 
MES N4  HN4  sing N N 237 
MES C5  C6   sing N N 238 
MES C5  H51  sing N N 239 
MES C5  H52  sing N N 240 
MES C6  H61  sing N N 241 
MES C6  H62  sing N N 242 
MES C7  C8   sing N N 243 
MES C7  H71  sing N N 244 
MES C7  H72  sing N N 245 
MES C8  S    sing N N 246 
MES C8  H81  sing N N 247 
MES C8  H82  sing N N 248 
MES S   O1S  doub N N 249 
MES S   O2S  doub N N 250 
MES S   O3S  sing N N 251 
MET N   CA   sing N N 252 
MET N   H    sing N N 253 
MET N   H2   sing N N 254 
MET CA  C    sing N N 255 
MET CA  CB   sing N N 256 
MET CA  HA   sing N N 257 
MET C   O    doub N N 258 
MET C   OXT  sing N N 259 
MET CB  CG   sing N N 260 
MET CB  HB2  sing N N 261 
MET CB  HB3  sing N N 262 
MET CG  SD   sing N N 263 
MET CG  HG2  sing N N 264 
MET CG  HG3  sing N N 265 
MET SD  CE   sing N N 266 
MET CE  HE1  sing N N 267 
MET CE  HE2  sing N N 268 
MET CE  HE3  sing N N 269 
MET OXT HXT  sing N N 270 
O3D C7  C6   doub Y N 271 
O3D C7  O3   sing Y N 272 
O3D C6  C5   sing Y N 273 
O3D O3  C4   sing Y N 274 
O3D C5  C4   doub Y N 275 
O3D C4  C3   sing N N 276 
O3D C3  N1   sing N N 277 
O3D N1  C2   sing N N 278 
O3D N1  C8   sing N N 279 
O3D C2  C1   sing N N 280 
O3D C8  C9   sing N N 281 
O3D C1  S1   sing N N 282 
O3D O1  S1   doub N N 283 
O3D C9  S1   sing N N 284 
O3D S1  O2   doub N N 285 
O3D C5  H2   sing N N 286 
O3D C6  H3   sing N N 287 
O3D C7  H4   sing N N 288 
O3D C8  H5   sing N N 289 
O3D C8  H6   sing N N 290 
O3D C1  H7   sing N N 291 
O3D C1  H8   sing N N 292 
O3D C2  H9   sing N N 293 
O3D C2  H10  sing N N 294 
O3D C3  H11  sing N N 295 
O3D C3  H12  sing N N 296 
O3D C9  H13  sing N N 297 
O3D C9  H14  sing N N 298 
PEG C1  O1   sing N N 299 
PEG C1  C2   sing N N 300 
PEG C1  H11  sing N N 301 
PEG C1  H12  sing N N 302 
PEG O1  HO1  sing N N 303 
PEG C2  O2   sing N N 304 
PEG C2  H21  sing N N 305 
PEG C2  H22  sing N N 306 
PEG O2  C3   sing N N 307 
PEG C3  C4   sing N N 308 
PEG C3  H31  sing N N 309 
PEG C3  H32  sing N N 310 
PEG C4  O4   sing N N 311 
PEG C4  H41  sing N N 312 
PEG C4  H42  sing N N 313 
PEG O4  HO4  sing N N 314 
PHE N   CA   sing N N 315 
PHE N   H    sing N N 316 
PHE N   H2   sing N N 317 
PHE CA  C    sing N N 318 
PHE CA  CB   sing N N 319 
PHE CA  HA   sing N N 320 
PHE C   O    doub N N 321 
PHE C   OXT  sing N N 322 
PHE CB  CG   sing N N 323 
PHE CB  HB2  sing N N 324 
PHE CB  HB3  sing N N 325 
PHE CG  CD1  doub Y N 326 
PHE CG  CD2  sing Y N 327 
PHE CD1 CE1  sing Y N 328 
PHE CD1 HD1  sing N N 329 
PHE CD2 CE2  doub Y N 330 
PHE CD2 HD2  sing N N 331 
PHE CE1 CZ   doub Y N 332 
PHE CE1 HE1  sing N N 333 
PHE CE2 CZ   sing Y N 334 
PHE CE2 HE2  sing N N 335 
PHE CZ  HZ   sing N N 336 
PHE OXT HXT  sing N N 337 
PO4 P   O1   doub N N 338 
PO4 P   O2   sing N N 339 
PO4 P   O3   sing N N 340 
PO4 P   O4   sing N N 341 
PRO N   CA   sing N N 342 
PRO N   CD   sing N N 343 
PRO N   H    sing N N 344 
PRO CA  C    sing N N 345 
PRO CA  CB   sing N N 346 
PRO CA  HA   sing N N 347 
PRO C   O    doub N N 348 
PRO C   OXT  sing N N 349 
PRO CB  CG   sing N N 350 
PRO CB  HB2  sing N N 351 
PRO CB  HB3  sing N N 352 
PRO CG  CD   sing N N 353 
PRO CG  HG2  sing N N 354 
PRO CG  HG3  sing N N 355 
PRO CD  HD2  sing N N 356 
PRO CD  HD3  sing N N 357 
PRO OXT HXT  sing N N 358 
SER N   CA   sing N N 359 
SER N   H    sing N N 360 
SER N   H2   sing N N 361 
SER CA  C    sing N N 362 
SER CA  CB   sing N N 363 
SER CA  HA   sing N N 364 
SER C   O    doub N N 365 
SER C   OXT  sing N N 366 
SER CB  OG   sing N N 367 
SER CB  HB2  sing N N 368 
SER CB  HB3  sing N N 369 
SER OG  HG   sing N N 370 
SER OXT HXT  sing N N 371 
THR N   CA   sing N N 372 
THR N   H    sing N N 373 
THR N   H2   sing N N 374 
THR CA  C    sing N N 375 
THR CA  CB   sing N N 376 
THR CA  HA   sing N N 377 
THR C   O    doub N N 378 
THR C   OXT  sing N N 379 
THR CB  OG1  sing N N 380 
THR CB  CG2  sing N N 381 
THR CB  HB   sing N N 382 
THR OG1 HG1  sing N N 383 
THR CG2 HG21 sing N N 384 
THR CG2 HG22 sing N N 385 
THR CG2 HG23 sing N N 386 
THR OXT HXT  sing N N 387 
TRP N   CA   sing N N 388 
TRP N   H    sing N N 389 
TRP N   H2   sing N N 390 
TRP CA  C    sing N N 391 
TRP CA  CB   sing N N 392 
TRP CA  HA   sing N N 393 
TRP C   O    doub N N 394 
TRP C   OXT  sing N N 395 
TRP CB  CG   sing N N 396 
TRP CB  HB2  sing N N 397 
TRP CB  HB3  sing N N 398 
TRP CG  CD1  doub Y N 399 
TRP CG  CD2  sing Y N 400 
TRP CD1 NE1  sing Y N 401 
TRP CD1 HD1  sing N N 402 
TRP CD2 CE2  doub Y N 403 
TRP CD2 CE3  sing Y N 404 
TRP NE1 CE2  sing Y N 405 
TRP NE1 HE1  sing N N 406 
TRP CE2 CZ2  sing Y N 407 
TRP CE3 CZ3  doub Y N 408 
TRP CE3 HE3  sing N N 409 
TRP CZ2 CH2  doub Y N 410 
TRP CZ2 HZ2  sing N N 411 
TRP CZ3 CH2  sing Y N 412 
TRP CZ3 HZ3  sing N N 413 
TRP CH2 HH2  sing N N 414 
TRP OXT HXT  sing N N 415 
TYR N   CA   sing N N 416 
TYR N   H    sing N N 417 
TYR N   H2   sing N N 418 
TYR CA  C    sing N N 419 
TYR CA  CB   sing N N 420 
TYR CA  HA   sing N N 421 
TYR C   O    doub N N 422 
TYR C   OXT  sing N N 423 
TYR CB  CG   sing N N 424 
TYR CB  HB2  sing N N 425 
TYR CB  HB3  sing N N 426 
TYR CG  CD1  doub Y N 427 
TYR CG  CD2  sing Y N 428 
TYR CD1 CE1  sing Y N 429 
TYR CD1 HD1  sing N N 430 
TYR CD2 CE2  doub Y N 431 
TYR CD2 HD2  sing N N 432 
TYR CE1 CZ   doub Y N 433 
TYR CE1 HE1  sing N N 434 
TYR CE2 CZ   sing Y N 435 
TYR CE2 HE2  sing N N 436 
TYR CZ  OH   sing N N 437 
TYR OH  HH   sing N N 438 
TYR OXT HXT  sing N N 439 
VAL N   CA   sing N N 440 
VAL N   H    sing N N 441 
VAL N   H2   sing N N 442 
VAL CA  C    sing N N 443 
VAL CA  CB   sing N N 444 
VAL CA  HA   sing N N 445 
VAL C   O    doub N N 446 
VAL C   OXT  sing N N 447 
VAL CB  CG1  sing N N 448 
VAL CB  CG2  sing N N 449 
VAL CB  HB   sing N N 450 
VAL CG1 HG11 sing N N 451 
VAL CG1 HG12 sing N N 452 
VAL CG1 HG13 sing N N 453 
VAL CG2 HG21 sing N N 454 
VAL CG2 HG22 sing N N 455 
VAL CG2 HG23 sing N N 456 
VAL OXT HXT  sing N N 457 
# 
_pdbx_audit_support.ordinal                1 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)' 
_pdbx_audit_support.grant_number           U19AI171292 
_pdbx_audit_support.country                'United States' 
# 
_pdbx_deposit_group.group_id            G_1002341 
_pdbx_deposit_group.group_description   
'Crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_title         
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_type          'changed state' 
# 
_atom_sites.entry_id                    7I2J 
_atom_sites.fract_transf_matrix[1][1]   0.012132 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.008616 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006745 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
# 
loop_
_atom_type.symbol 
C  
CL 
N  
O  
P  
S  
ZN 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ASN A 1 10  ? -13.971 -5.157  -12.955 0.35 81.54  ? 273  ASN A N   1 
ATOM   2    C  CA  . ASN A 1 10  ? -13.663 -6.364  -12.128 0.35 80.46  ? 273  ASN A CA  1 
ATOM   3    C  C   . ASN A 1 10  ? -14.640 -6.424  -10.945 0.35 79.13  ? 273  ASN A C   1 
ATOM   4    O  O   . ASN A 1 10  ? -15.566 -7.255  -10.998 0.35 76.64  ? 273  ASN A O   1 
ATOM   5    C  CB  . ASN A 1 10  ? -12.196 -6.384  -11.683 0.35 80.66  ? 273  ASN A CB  1 
ATOM   6    C  CG  . ASN A 1 10  ? -11.781 -7.689  -11.035 0.35 81.14  ? 273  ASN A CG  1 
ATOM   7    O  OD1 . ASN A 1 10  ? -11.887 -8.752  -11.646 0.35 78.75  ? 273  ASN A OD1 1 
ATOM   8    N  ND2 . ASN A 1 10  ? -11.292 -7.622  -9.806  0.35 82.07  ? 273  ASN A ND2 1 
ATOM   9    N  N   . LEU A 1 11  ? -14.460 -5.558  -9.939  0.35 79.75  ? 274  LEU A N   1 
ATOM   10   C  CA  . LEU A 1 11  ? -15.225 -5.591  -8.659  0.35 77.48  ? 274  LEU A CA  1 
ATOM   11   C  C   . LEU A 1 11  ? -16.671 -5.142  -8.892  0.35 73.47  ? 274  LEU A C   1 
ATOM   12   O  O   . LEU A 1 11  ? -17.540 -5.560  -8.101  0.35 69.98  ? 274  LEU A O   1 
ATOM   13   C  CB  . LEU A 1 11  ? -14.537 -4.720  -7.602  0.35 80.48  ? 274  LEU A CB  1 
ATOM   14   C  CG  . LEU A 1 11  ? -13.936 -5.487  -6.424  0.35 83.00  ? 274  LEU A CG  1 
ATOM   15   C  CD1 . LEU A 1 11  ? -12.986 -4.608  -5.627  0.35 84.42  ? 274  LEU A CD1 1 
ATOM   16   C  CD2 . LEU A 1 11  ? -15.032 -6.044  -5.526  0.35 82.42  ? 274  LEU A CD2 1 
ATOM   17   N  N   . ASP A 1 12  ? -16.921 -4.331  -9.926  0.35 71.21  ? 275  ASP A N   1 
ATOM   18   C  CA  . ASP A 1 12  ? -18.293 -3.916  -10.324 0.35 72.91  ? 275  ASP A CA  1 
ATOM   19   C  C   . ASP A 1 12  ? -19.045 -5.146  -10.852 0.35 71.48  ? 275  ASP A C   1 
ATOM   20   O  O   . ASP A 1 12  ? -20.271 -5.221  -10.625 0.35 70.58  ? 275  ASP A O   1 
ATOM   21   C  CB  . ASP A 1 12  ? -18.274 -2.758  -11.329 0.35 75.17  ? 275  ASP A CB  1 
ATOM   22   C  CG  . ASP A 1 12  ? -17.971 -3.166  -12.760 0.35 76.55  ? 275  ASP A CG  1 
ATOM   23   O  OD1 . ASP A 1 12  ? -16.821 -3.577  -13.019 0.35 79.09  ? 275  ASP A OD1 1 
ATOM   24   O  OD2 . ASP A 1 12  ? -18.890 -3.077  -13.602 0.35 73.98  ? 275  ASP A OD2 1 
ATOM   25   N  N   . ILE A 1 13  ? -18.335 -6.084  -11.495 0.35 70.70  ? 276  ILE A N   1 
ATOM   26   C  CA  . ILE A 1 13  ? -18.939 -7.298  -12.127 0.35 65.07  ? 276  ILE A CA  1 
ATOM   27   C  C   . ILE A 1 13  ? -19.258 -8.342  -11.047 0.35 63.15  ? 276  ILE A C   1 
ATOM   28   O  O   . ILE A 1 13  ? -20.294 -9.029  -11.190 0.35 58.58  ? 276  ILE A O   1 
ATOM   29   C  CB  . ILE A 1 13  ? -18.022 -7.857  -13.234 0.35 64.67  ? 276  ILE A CB  1 
ATOM   30   C  CG1 . ILE A 1 13  ? -17.927 -6.884  -14.413 0.35 63.15  ? 276  ILE A CG1 1 
ATOM   31   C  CG2 . ILE A 1 13  ? -18.479 -9.242  -13.674 0.35 64.94  ? 276  ILE A CG2 1 
ATOM   32   C  CD1 . ILE A 1 13  ? -16.962 -7.309  -15.497 0.35 62.90  ? 276  ILE A CD1 1 
ATOM   33   N  N   . ILE A 1 14  ? -18.411 -8.457  -10.016 1.00 61.46  ? 277  ILE A N   1 
ATOM   34   C  CA  . ILE A 1 14  ? -18.563 -9.489  -8.938  1.00 66.67  ? 277  ILE A CA  1 
ATOM   35   C  C   . ILE A 1 14  ? -19.134 -8.914  -7.626  1.00 70.74  ? 277  ILE A C   1 
ATOM   36   O  O   . ILE A 1 14  ? -19.607 -9.736  -6.787  1.00 69.54  ? 277  ILE A O   1 
ATOM   37   C  CB  . ILE A 1 14  ? -17.226 -10.223 -8.699  1.00 77.12  ? 277  ILE A CB  1 
ATOM   38   C  CG1 . ILE A 1 14  ? -16.120 -9.292  -8.194  1.00 73.42  ? 277  ILE A CG1 1 
ATOM   39   C  CG2 . ILE A 1 14  ? -16.796 -10.977 -9.954  1.00 77.66  ? 277  ILE A CG2 1 
ATOM   40   C  CD1 . ILE A 1 14  ? -14.936 -10.021 -7.600  1.00 74.86  ? 277  ILE A CD1 1 
ATOM   41   N  N   . GLY A 1 15  ? -19.102 -7.588  -7.433  1.00 78.77  ? 278  GLY A N   1 
ATOM   42   C  CA  . GLY A 1 15  ? -19.526 -6.906  -6.189  1.00 76.06  ? 278  GLY A CA  1 
ATOM   43   C  C   . GLY A 1 15  ? -20.917 -7.317  -5.730  1.00 75.25  ? 278  GLY A C   1 
ATOM   44   O  O   . GLY A 1 15  ? -21.081 -7.679  -4.547  1.00 82.16  ? 278  GLY A O   1 
ATOM   45   N  N   . LYS A 1 16  ? -21.896 -7.261  -6.639  0.35 75.42  ? 279  LYS A N   1 
ATOM   46   C  CA  . LYS A 1 16  ? -23.335 -7.526  -6.359  0.35 74.90  ? 279  LYS A CA  1 
ATOM   47   C  C   . LYS A 1 16  ? -23.496 -8.939  -5.784  0.35 75.42  ? 279  LYS A C   1 
ATOM   48   O  O   . LYS A 1 16  ? -24.212 -9.087  -4.770  0.35 71.80  ? 279  LYS A O   1 
ATOM   49   C  CB  . LYS A 1 16  ? -24.161 -7.346  -7.637  0.35 76.44  ? 279  LYS A CB  1 
ATOM   50   C  CG  . LYS A 1 16  ? -25.671 -7.429  -7.462  0.35 77.30  ? 279  LYS A CG  1 
ATOM   51   C  CD  . LYS A 1 16  ? -26.438 -6.797  -8.609  0.35 78.29  ? 279  LYS A CD  1 
ATOM   52   C  CE  . LYS A 1 16  ? -27.934 -7.016  -8.527  0.35 79.70  ? 279  LYS A CE  1 
ATOM   53   N  NZ  . LYS A 1 16  ? -28.495 -6.533  -7.243  0.35 80.33  ? 279  LYS A NZ  1 
ATOM   54   N  N   . ARG A 1 17  ? -22.852 -9.929  -6.412  0.35 76.12  ? 280  ARG A N   1 
ATOM   55   C  CA  . ARG A 1 17  ? -22.851 -11.351 -5.972  0.35 77.12  ? 280  ARG A CA  1 
ATOM   56   C  C   . ARG A 1 17  ? -22.257 -11.447 -4.561  0.35 77.86  ? 280  ARG A C   1 
ATOM   57   O  O   . ARG A 1 17  ? -22.845 -12.160 -3.724  0.35 78.90  ? 280  ARG A O   1 
ATOM   58   C  CB  . ARG A 1 17  ? -22.070 -12.232 -6.956  0.35 76.82  ? 280  ARG A CB  1 
ATOM   59   C  CG  . ARG A 1 17  ? -22.925 -12.848 -8.055  0.35 75.76  ? 280  ARG A CG  1 
ATOM   60   C  CD  . ARG A 1 17  ? -22.096 -13.546 -9.116  0.35 73.28  ? 280  ARG A CD  1 
ATOM   61   N  NE  . ARG A 1 17  ? -21.377 -12.598 -9.954  0.35 72.76  ? 280  ARG A NE  1 
ATOM   62   C  CZ  . ARG A 1 17  ? -20.540 -12.928 -10.934 0.35 72.31  ? 280  ARG A CZ  1 
ATOM   63   N  NH1 . ARG A 1 17  ? -20.301 -14.199 -11.216 0.35 72.48  ? 280  ARG A NH1 1 
ATOM   64   N  NH2 . ARG A 1 17  ? -19.943 -11.979 -11.634 0.35 71.83  ? 280  ARG A NH2 1 
ATOM   65   N  N   . ILE A 1 18  ? -21.142 -10.749 -4.315  0.35 80.16  ? 281  ILE A N   1 
ATOM   66   C  CA  . ILE A 1 18  ? -20.419 -10.744 -3.007  0.35 82.16  ? 281  ILE A CA  1 
ATOM   67   C  C   . ILE A 1 18  ? -21.274 -9.992  -1.979  0.35 84.43  ? 281  ILE A C   1 
ATOM   68   O  O   . ILE A 1 18  ? -21.556 -10.579 -0.913  0.35 85.58  ? 281  ILE A O   1 
ATOM   69   C  CB  . ILE A 1 18  ? -19.005 -10.139 -3.157  0.35 83.34  ? 281  ILE A CB  1 
ATOM   70   C  CG1 . ILE A 1 18  ? -18.127 -10.980 -4.088  0.35 84.23  ? 281  ILE A CG1 1 
ATOM   71   C  CG2 . ILE A 1 18  ? -18.347 -9.950  -1.797  0.35 83.83  ? 281  ILE A CG2 1 
ATOM   72   C  CD1 . ILE A 1 18  ? -16.956 -10.230 -4.677  0.35 84.96  ? 281  ILE A CD1 1 
ATOM   73   N  N   . GLU A 1 19  ? -21.687 -8.760  -2.304  0.35 86.07  ? 282  GLU A N   1 
ATOM   74   C  CA  . GLU A 1 19  ? -22.480 -7.858  -1.419  0.35 87.37  ? 282  GLU A CA  1 
ATOM   75   C  C   . GLU A 1 19  ? -23.790 -8.541  -1.006  0.35 84.84  ? 282  GLU A C   1 
ATOM   76   O  O   . GLU A 1 19  ? -24.238 -8.289  0.128   0.35 83.66  ? 282  GLU A O   1 
ATOM   77   C  CB  . GLU A 1 19  ? -22.753 -6.517  -2.107  0.35 89.39  ? 282  GLU A CB  1 
ATOM   78   C  CG  . GLU A 1 19  ? -21.545 -5.594  -2.125  0.35 89.36  ? 282  GLU A CG  1 
ATOM   79   C  CD  . GLU A 1 19  ? -21.704 -4.333  -2.958  0.35 90.89  ? 282  GLU A CD  1 
ATOM   80   O  OE1 . GLU A 1 19  ? -22.735 -3.646  -2.802  0.35 92.04  ? 282  GLU A OE1 1 
ATOM   81   O  OE2 . GLU A 1 19  ? -20.793 -4.039  -3.762  0.35 89.09  ? 282  GLU A OE2 1 
ATOM   82   N  N   . LYS A 1 20  ? -24.376 -9.362  -1.888  0.35 85.89  ? 283  LYS A N   1 
ATOM   83   C  CA  . LYS A 1 20  ? -25.596 -10.166 -1.601  0.35 86.51  ? 283  LYS A CA  1 
ATOM   84   C  C   . LYS A 1 20  ? -25.273 -11.210 -0.525  0.35 87.78  ? 283  LYS A C   1 
ATOM   85   O  O   . LYS A 1 20  ? -25.913 -11.163 0.544   0.35 88.18  ? 283  LYS A O   1 
ATOM   86   C  CB  . LYS A 1 20  ? -26.130 -10.845 -2.867  0.35 87.20  ? 283  LYS A CB  1 
ATOM   87   C  CG  . LYS A 1 20  ? -27.281 -11.819 -2.638  0.35 86.50  ? 283  LYS A CG  1 
ATOM   88   C  CD  . LYS A 1 20  ? -28.135 -12.070 -3.864  0.35 87.50  ? 283  LYS A CD  1 
ATOM   89   C  CE  . LYS A 1 20  ? -29.454 -12.746 -3.545  0.35 87.56  ? 283  LYS A CE  1 
ATOM   90   N  NZ  . LYS A 1 20  ? -29.264 -14.119 -3.020  0.35 87.39  ? 283  LYS A NZ  1 
ATOM   91   N  N   . ILE A 1 21  ? -24.311 -12.100 -0.801  0.35 87.20  ? 284  ILE A N   1 
ATOM   92   C  CA  . ILE A 1 21  ? -23.926 -13.252 0.074   0.35 87.98  ? 284  ILE A CA  1 
ATOM   93   C  C   . ILE A 1 21  ? -23.713 -12.749 1.507   0.35 86.46  ? 284  ILE A C   1 
ATOM   94   O  O   . ILE A 1 21  ? -24.214 -13.411 2.441   0.35 83.90  ? 284  ILE A O   1 
ATOM   95   C  CB  . ILE A 1 21  ? -22.675 -13.976 -0.474  0.35 89.32  ? 284  ILE A CB  1 
ATOM   96   C  CG1 . ILE A 1 21  ? -22.988 -14.754 -1.755  0.35 88.55  ? 284  ILE A CG1 1 
ATOM   97   C  CG2 . ILE A 1 21  ? -22.057 -14.880 0.586   0.35 88.85  ? 284  ILE A CG2 1 
ATOM   98   C  CD1 . ILE A 1 21  ? -21.773 -15.066 -2.601  0.35 87.88  ? 284  ILE A CD1 1 
ATOM   99   N  N   . LYS A 1 22  ? -22.995 -11.630 1.663   0.35 85.40  ? 285  LYS A N   1 
ATOM   100  C  CA  . LYS A 1 22  ? -22.680 -10.991 2.971   0.35 86.76  ? 285  LYS A CA  1 
ATOM   101  C  C   . LYS A 1 22  ? -23.966 -10.845 3.794   0.35 84.77  ? 285  LYS A C   1 
ATOM   102  O  O   . LYS A 1 22  ? -24.008 -11.380 4.918   0.35 80.34  ? 285  LYS A O   1 
ATOM   103  C  CB  . LYS A 1 22  ? -22.011 -9.629  2.754   0.35 89.41  ? 285  LYS A CB  1 
ATOM   104  C  CG  . LYS A 1 22  ? -21.653 -8.867  4.026   0.35 91.43  ? 285  LYS A CG  1 
ATOM   105  C  CD  . LYS A 1 22  ? -20.919 -7.564  3.778   0.35 91.82  ? 285  LYS A CD  1 
ATOM   106  C  CE  . LYS A 1 22  ? -20.736 -6.743  5.038   0.35 90.70  ? 285  LYS A CE  1 
ATOM   107  N  NZ  . LYS A 1 22  ? -20.134 -5.421  4.750   0.35 89.63  ? 285  LYS A NZ  1 
ATOM   108  N  N   . GLN A 1 23  ? -24.975 -10.167 3.237   0.35 85.74  ? 286  GLN A N   1 
ATOM   109  C  CA  . GLN A 1 23  ? -26.226 -9.768  3.941   0.35 84.91  ? 286  GLN A CA  1 
ATOM   110  C  C   . GLN A 1 23  ? -26.943 -11.001 4.506   0.35 85.46  ? 286  GLN A C   1 
ATOM   111  O  O   . GLN A 1 23  ? -27.540 -10.878 5.593   0.35 86.67  ? 286  GLN A O   1 
ATOM   112  C  CB  . GLN A 1 23  ? -27.152 -8.985  3.008   0.35 83.59  ? 286  GLN A CB  1 
ATOM   113  C  CG  . GLN A 1 23  ? -26.553 -7.668  2.530   0.35 83.69  ? 286  GLN A CG  1 
ATOM   114  C  CD  . GLN A 1 23  ? -27.403 -6.474  2.892   0.35 83.51  ? 286  GLN A CD  1 
ATOM   115  O  OE1 . GLN A 1 23  ? -28.621 -6.476  2.721   0.35 82.43  ? 286  GLN A OE1 1 
ATOM   116  N  NE2 . GLN A 1 23  ? -26.762 -5.434  3.403   0.35 81.98  ? 286  GLN A NE2 1 
ATOM   117  N  N   . GLU A 1 24  ? -26.890 -12.136 3.802   0.35 86.99  ? 287  GLU A N   1 
ATOM   118  C  CA  . GLU A 1 24  ? -27.544 -13.404 4.225   0.35 90.46  ? 287  GLU A CA  1 
ATOM   119  C  C   . GLU A 1 24  ? -26.771 -14.019 5.402   0.35 97.34  ? 287  GLU A C   1 
ATOM   120  O  O   . GLU A 1 24  ? -27.418 -14.693 6.230   0.35 99.66  ? 287  GLU A O   1 
ATOM   121  C  CB  . GLU A 1 24  ? -27.657 -14.384 3.054   0.35 88.24  ? 287  GLU A CB  1 
ATOM   122  C  CG  . GLU A 1 24  ? -28.775 -14.042 2.083   0.35 86.78  ? 287  GLU A CG  1 
ATOM   123  C  CD  . GLU A 1 24  ? -28.437 -12.955 1.077   0.35 84.59  ? 287  GLU A CD  1 
ATOM   124  O  OE1 . GLU A 1 24  ? -28.906 -11.812 1.259   0.35 79.84  ? 287  GLU A OE1 1 
ATOM   125  O  OE2 . GLU A 1 24  ? -27.713 -13.257 0.108   0.35 81.92  ? 287  GLU A OE2 1 
ATOM   126  N  N   . HIS A 1 25  ? -25.450 -13.805 5.475   1.00 105.35 ? 288  HIS A N   1 
ATOM   127  C  CA  . HIS A 1 25  ? -24.598 -14.327 6.583   1.00 105.75 ? 288  HIS A CA  1 
ATOM   128  C  C   . HIS A 1 25  ? -23.818 -13.183 7.246   1.00 111.60 ? 288  HIS A C   1 
ATOM   129  O  O   . HIS A 1 25  ? -22.605 -13.346 7.514   1.00 116.10 ? 288  HIS A O   1 
ATOM   130  C  CB  . HIS A 1 25  ? -23.680 -15.434 6.048   1.00 94.07  ? 288  HIS A CB  1 
ATOM   131  C  CG  . HIS A 1 25  ? -24.396 -16.489 5.275   1.00 91.64  ? 288  HIS A CG  1 
ATOM   132  N  ND1 . HIS A 1 25  ? -25.049 -17.546 5.890   1.00 101.87 ? 288  HIS A ND1 1 
ATOM   133  C  CD2 . HIS A 1 25  ? -24.551 -16.674 3.948   1.00 87.05  ? 288  HIS A CD2 1 
ATOM   134  C  CE1 . HIS A 1 25  ? -25.576 -18.333 4.975   1.00 90.61  ? 288  HIS A CE1 1 
ATOM   135  N  NE2 . HIS A 1 25  ? -25.288 -17.816 3.777   1.00 86.22  ? 288  HIS A NE2 1 
ATOM   136  N  N   . GLU A 1 26  ? -24.495 -12.058 7.503   0.35 115.96 ? 289  GLU A N   1 
ATOM   137  C  CA  . GLU A 1 26  ? -23.893 -10.828 8.090   0.35 120.13 ? 289  GLU A CA  1 
ATOM   138  C  C   . GLU A 1 26  ? -23.761 -10.992 9.612   0.35 125.40 ? 289  GLU A C   1 
ATOM   139  O  O   . GLU A 1 26  ? -23.107 -10.135 10.241  0.35 123.67 ? 289  GLU A O   1 
ATOM   140  C  CB  . GLU A 1 26  ? -24.729 -9.599  7.725   0.35 119.32 ? 289  GLU A CB  1 
ATOM   141  C  CG  . GLU A 1 26  ? -23.986 -8.284  7.903   0.35 118.85 ? 289  GLU A CG  1 
ATOM   142  C  CD  . GLU A 1 26  ? -24.548 -7.107  7.123   0.35 117.82 ? 289  GLU A CD  1 
ATOM   143  O  OE1 . GLU A 1 26  ? -23.795 -6.139  6.901   0.35 117.47 ? 289  GLU A OE1 1 
ATOM   144  O  OE2 . GLU A 1 26  ? -25.734 -7.158  6.740   0.35 117.25 ? 289  GLU A OE2 1 
ATOM   145  N  N   . THR A 1 27  ? -24.351 -12.052 10.176  0.35 129.87 ? 290  THR A N   1 
ATOM   146  C  CA  . THR A 1 27  ? -24.254 -12.422 11.614  0.35 132.82 ? 290  THR A CA  1 
ATOM   147  C  C   . THR A 1 27  ? -22.955 -13.203 11.872  0.35 134.00 ? 290  THR A C   1 
ATOM   148  O  O   . THR A 1 27  ? -22.622 -13.384 13.061  0.35 136.24 ? 290  THR A O   1 
ATOM   149  C  CB  . THR A 1 27  ? -25.493 -13.208 12.062  0.35 134.64 ? 290  THR A CB  1 
ATOM   150  O  OG1 . THR A 1 27  ? -25.604 -14.381 11.254  0.35 138.50 ? 290  THR A OG1 1 
ATOM   151  C  CG2 . THR A 1 27  ? -26.771 -12.404 11.959  0.35 133.53 ? 290  THR A CG2 1 
ATOM   152  N  N   . SER A 1 28  ? -22.254 -13.644 10.817  0.35 131.47 ? 291  SER A N   1 
ATOM   153  C  CA  . SER A 1 28  ? -21.000 -14.444 10.902  0.35 127.15 ? 291  SER A CA  1 
ATOM   154  C  C   . SER A 1 28  ? -19.906 -13.903 9.966   0.35 126.02 ? 291  SER A C   1 
ATOM   155  O  O   . SER A 1 28  ? -18.886 -14.602 9.812   0.35 123.91 ? 291  SER A O   1 
ATOM   156  C  CB  . SER A 1 28  ? -21.281 -15.897 10.606  0.35 124.97 ? 291  SER A CB  1 
ATOM   157  O  OG  . SER A 1 28  ? -22.279 -16.411 11.476  0.35 121.44 ? 291  SER A OG  1 
ATOM   158  N  N   . TRP A 1 29  ? -20.081 -12.710 9.384   0.35 126.27 ? 292  TRP A N   1 
ATOM   159  C  CA  . TRP A 1 29  ? -19.133 -12.126 8.393   0.35 128.49 ? 292  TRP A CA  1 
ATOM   160  C  C   . TRP A 1 29  ? -17.835 -11.720 9.101   0.35 129.51 ? 292  TRP A C   1 
ATOM   161  O  O   . TRP A 1 29  ? -17.920 -11.023 10.132  0.35 132.34 ? 292  TRP A O   1 
ATOM   162  C  CB  . TRP A 1 29  ? -19.768 -10.945 7.644   0.35 126.66 ? 292  TRP A CB  1 
ATOM   163  C  CG  . TRP A 1 29  ? -19.071 -10.584 6.366   0.35 125.64 ? 292  TRP A CG  1 
ATOM   164  C  CD1 . TRP A 1 29  ? -18.344 -9.456  6.114   0.35 124.98 ? 292  TRP A CD1 1 
ATOM   165  C  CD2 . TRP A 1 29  ? -19.035 -11.360 5.154   0.35 124.73 ? 292  TRP A CD2 1 
ATOM   166  N  NE1 . TRP A 1 29  ? -17.862 -9.475  4.832   0.35 124.27 ? 292  TRP A NE1 1 
ATOM   167  C  CE2 . TRP A 1 29  ? -18.269 -10.630 4.218   0.35 124.59 ? 292  TRP A CE2 1 
ATOM   168  C  CE3 . TRP A 1 29  ? -19.574 -12.594 4.767   0.35 123.00 ? 292  TRP A CE3 1 
ATOM   169  C  CZ2 . TRP A 1 29  ? -18.032 -11.097 2.925   0.35 123.35 ? 292  TRP A CZ2 1 
ATOM   170  C  CZ3 . TRP A 1 29  ? -19.338 -13.054 3.489   0.35 122.05 ? 292  TRP A CZ3 1 
ATOM   171  C  CH2 . TRP A 1 29  ? -18.577 -12.314 2.583   0.35 121.94 ? 292  TRP A CH2 1 
ATOM   172  N  N   . HIS A 1 30  ? -16.685 -12.153 8.571   0.35 129.47 ? 293  HIS A N   1 
ATOM   173  C  CA  . HIS A 1 30  ? -15.329 -11.853 9.109   0.35 128.47 ? 293  HIS A CA  1 
ATOM   174  C  C   . HIS A 1 30  ? -14.278 -12.003 8.003   0.35 129.17 ? 293  HIS A C   1 
ATOM   175  O  O   . HIS A 1 30  ? -14.353 -12.994 7.249   0.35 129.14 ? 293  HIS A O   1 
ATOM   176  C  CB  . HIS A 1 30  ? -15.022 -12.747 10.320  0.35 127.47 ? 293  HIS A CB  1 
ATOM   177  C  CG  . HIS A 1 30  ? -14.914 -14.202 10.005  0.35 124.70 ? 293  HIS A CG  1 
ATOM   178  N  ND1 . HIS A 1 30  ? -16.013 -15.038 9.986   0.35 124.80 ? 293  HIS A ND1 1 
ATOM   179  C  CD2 . HIS A 1 30  ? -13.845 -14.975 9.714   0.35 124.66 ? 293  HIS A CD2 1 
ATOM   180  C  CE1 . HIS A 1 30  ? -15.627 -16.263 9.690   0.35 124.79 ? 293  HIS A CE1 1 
ATOM   181  N  NE2 . HIS A 1 30  ? -14.301 -16.252 9.520   0.35 125.53 ? 293  HIS A NE2 1 
ATOM   182  N  N   . TYR A 1 31  ? -13.342 -11.051 7.915   0.35 130.42 ? 294  TYR A N   1 
ATOM   183  C  CA  . TYR A 1 31  ? -12.181 -11.080 6.987   0.35 131.57 ? 294  TYR A CA  1 
ATOM   184  C  C   . TYR A 1 31  ? -10.979 -11.704 7.707   0.35 133.30 ? 294  TYR A C   1 
ATOM   185  O  O   . TYR A 1 31  ? -10.314 -11.003 8.495   0.35 136.37 ? 294  TYR A O   1 
ATOM   186  C  CB  . TYR A 1 31  ? -11.849 -9.680  6.463   0.35 131.83 ? 294  TYR A CB  1 
ATOM   187  C  CG  . TYR A 1 31  ? -10.860 -9.679  5.324   0.35 133.54 ? 294  TYR A CG  1 
ATOM   188  C  CD1 . TYR A 1 31  ? -9.493  -9.688  5.557   0.35 133.09 ? 294  TYR A CD1 1 
ATOM   189  C  CD2 . TYR A 1 31  ? -11.290 -9.697  4.008   0.35 134.44 ? 294  TYR A CD2 1 
ATOM   190  C  CE1 . TYR A 1 31  ? -8.582  -9.702  4.513   0.35 132.27 ? 294  TYR A CE1 1 
ATOM   191  C  CE2 . TYR A 1 31  ? -10.394 -9.710  2.951   0.35 133.10 ? 294  TYR A CE2 1 
ATOM   192  C  CZ  . TYR A 1 31  ? -9.033  -9.712  3.205   0.35 131.97 ? 294  TYR A CZ  1 
ATOM   193  O  OH  . TYR A 1 31  ? -8.145  -9.725  2.169   0.35 129.93 ? 294  TYR A OH  1 
ATOM   194  N  N   . ASP A 1 32  ? -10.719 -12.987 7.438   0.35 135.18 ? 295  ASP A N   1 
ATOM   195  C  CA  . ASP A 1 32  ? -9.594  -13.768 8.021   0.35 135.17 ? 295  ASP A CA  1 
ATOM   196  C  C   . ASP A 1 32  ? -8.284  -13.325 7.357   0.35 135.65 ? 295  ASP A C   1 
ATOM   197  O  O   . ASP A 1 32  ? -8.175  -13.461 6.121   0.35 136.03 ? 295  ASP A O   1 
ATOM   198  C  CB  . ASP A 1 32  ? -9.837  -15.272 7.857   0.35 133.18 ? 295  ASP A CB  1 
ATOM   199  C  CG  . ASP A 1 32  ? -8.725  -16.152 8.402   0.35 130.78 ? 295  ASP A CG  1 
ATOM   200  O  OD1 . ASP A 1 32  ? -8.118  -15.772 9.423   0.35 128.43 ? 295  ASP A OD1 1 
ATOM   201  O  OD2 . ASP A 1 32  ? -8.475  -17.214 7.796   0.35 128.72 ? 295  ASP A OD2 1 
ATOM   202  N  N   . GLN A 1 33  ? -7.334  -12.815 8.152   0.35 134.88 ? 296  GLN A N   1 
ATOM   203  C  CA  . GLN A 1 33  ? -5.992  -12.363 7.688   0.35 132.58 ? 296  GLN A CA  1 
ATOM   204  C  C   . GLN A 1 33  ? -5.061  -13.574 7.532   0.35 129.71 ? 296  GLN A C   1 
ATOM   205  O  O   . GLN A 1 33  ? -4.008  -13.418 6.881   0.35 127.24 ? 296  GLN A O   1 
ATOM   206  C  CB  . GLN A 1 33  ? -5.396  -11.339 8.658   0.35 132.44 ? 296  GLN A CB  1 
ATOM   207  C  CG  . GLN A 1 33  ? -6.128  -10.003 8.660   0.35 132.10 ? 296  GLN A CG  1 
ATOM   208  C  CD  . GLN A 1 33  ? -5.338  -8.895  9.315   0.35 130.79 ? 296  GLN A CD  1 
ATOM   209  O  OE1 . GLN A 1 33  ? -4.320  -9.124  9.966   0.35 127.60 ? 296  GLN A OE1 1 
ATOM   210  N  NE2 . GLN A 1 33  ? -5.807  -7.669  9.146   0.35 128.88 ? 296  GLN A NE2 1 
ATOM   211  N  N   . ASP A 1 34  ? -5.431  -14.725 8.108   0.35 126.78 ? 297  ASP A N   1 
ATOM   212  C  CA  . ASP A 1 34  ? -4.707  -16.018 7.969   0.35 125.33 ? 297  ASP A CA  1 
ATOM   213  C  C   . ASP A 1 34  ? -5.404  -16.873 6.901   0.35 122.93 ? 297  ASP A C   1 
ATOM   214  O  O   . ASP A 1 34  ? -5.592  -18.083 7.143   0.35 123.72 ? 297  ASP A O   1 
ATOM   215  C  CB  . ASP A 1 34  ? -4.618  -16.747 9.315   0.35 125.44 ? 297  ASP A CB  1 
ATOM   216  C  CG  . ASP A 1 34  ? -3.826  -16.004 10.380  0.35 125.37 ? 297  ASP A CG  1 
ATOM   217  O  OD1 . ASP A 1 34  ? -2.906  -15.245 10.010  0.35 123.36 ? 297  ASP A OD1 1 
ATOM   218  O  OD2 . ASP A 1 34  ? -4.134  -16.195 11.574  0.35 124.01 ? 297  ASP A OD2 1 
ATOM   219  N  N   . HIS A 1 35  ? -5.766  -16.267 5.763   0.35 117.53 ? 298  HIS A N   1 
ATOM   220  C  CA  . HIS A 1 35  ? -6.399  -16.950 4.601   0.35 111.75 ? 298  HIS A CA  1 
ATOM   221  C  C   . HIS A 1 35  ? -5.301  -17.556 3.729   0.35 106.34 ? 298  HIS A C   1 
ATOM   222  O  O   . HIS A 1 35  ? -4.312  -16.891 3.425   0.35 106.55 ? 298  HIS A O   1 
ATOM   223  C  CB  . HIS A 1 35  ? -7.334  -15.993 3.838   0.35 110.69 ? 298  HIS A CB  1 
ATOM   224  C  CG  . HIS A 1 35  ? -6.651  -14.875 3.121   0.35 109.04 ? 298  HIS A CG  1 
ATOM   225  N  ND1 . HIS A 1 35  ? -6.591  -13.594 3.636   0.35 110.12 ? 298  HIS A ND1 1 
ATOM   226  C  CD2 . HIS A 1 35  ? -6.022  -14.830 1.926   0.35 108.82 ? 298  HIS A CD2 1 
ATOM   227  C  CE1 . HIS A 1 35  ? -5.945  -12.813 2.796   0.35 109.29 ? 298  HIS A CE1 1 
ATOM   228  N  NE2 . HIS A 1 35  ? -5.583  -13.547 1.738   0.35 108.93 ? 298  HIS A NE2 1 
ATOM   229  N  N   . PRO A 1 36  ? -5.431  -18.837 3.305   0.35 98.38  ? 299  PRO A N   1 
ATOM   230  C  CA  . PRO A 1 36  ? -4.367  -19.516 2.560   0.35 94.89  ? 299  PRO A CA  1 
ATOM   231  C  C   . PRO A 1 36  ? -4.220  -19.085 1.091   0.35 93.74  ? 299  PRO A C   1 
ATOM   232  O  O   . PRO A 1 36  ? -3.238  -19.459 0.475   0.35 90.21  ? 299  PRO A O   1 
ATOM   233  C  CB  . PRO A 1 36  ? -4.797  -20.990 2.628   0.35 94.04  ? 299  PRO A CB  1 
ATOM   234  C  CG  . PRO A 1 36  ? -6.307  -20.931 2.696   0.35 94.65  ? 299  PRO A CG  1 
ATOM   235  C  CD  . PRO A 1 36  ? -6.605  -19.698 3.523   0.35 96.09  ? 299  PRO A CD  1 
ATOM   236  N  N   . TYR A 1 37  ? -5.177  -18.307 0.573   0.35 93.37  ? 300  TYR A N   1 
ATOM   237  C  CA  . TYR A 1 37  ? -5.334  -17.998 -0.873  0.35 92.28  ? 300  TYR A CA  1 
ATOM   238  C  C   . TYR A 1 37  ? -4.244  -17.013 -1.309  0.35 94.40  ? 300  TYR A C   1 
ATOM   239  O  O   . TYR A 1 37  ? -4.094  -15.953 -0.666  0.35 95.75  ? 300  TYR A O   1 
ATOM   240  C  CB  . TYR A 1 37  ? -6.744  -17.469 -1.158  0.35 88.98  ? 300  TYR A CB  1 
ATOM   241  C  CG  . TYR A 1 37  ? -7.843  -18.367 -0.648  0.35 83.49  ? 300  TYR A CG  1 
ATOM   242  C  CD1 . TYR A 1 37  ? -8.161  -19.548 -1.297  0.35 81.13  ? 300  TYR A CD1 1 
ATOM   243  C  CD2 . TYR A 1 37  ? -8.541  -18.057 0.508   0.35 82.42  ? 300  TYR A CD2 1 
ATOM   244  C  CE1 . TYR A 1 37  ? -9.153  -20.391 -0.821  0.35 79.27  ? 300  TYR A CE1 1 
ATOM   245  C  CE2 . TYR A 1 37  ? -9.537  -18.887 0.998   0.35 80.42  ? 300  TYR A CE2 1 
ATOM   246  C  CZ  . TYR A 1 37  ? -9.844  -20.059 0.330   0.35 78.30  ? 300  TYR A CZ  1 
ATOM   247  O  OH  . TYR A 1 37  ? -10.821 -20.882 0.806   0.35 78.22  ? 300  TYR A OH  1 
ATOM   248  N  N   . LYS A 1 38  ? -3.499  -17.376 -2.359  0.35 95.29  ? 301  LYS A N   1 
ATOM   249  C  CA  . LYS A 1 38  ? -2.453  -16.529 -2.994  0.35 97.06  ? 301  LYS A CA  1 
ATOM   250  C  C   . LYS A 1 38  ? -2.912  -16.131 -4.403  0.35 97.18  ? 301  LYS A C   1 
ATOM   251  O  O   . LYS A 1 38  ? -2.906  -14.920 -4.698  0.35 99.41  ? 301  LYS A O   1 
ATOM   252  C  CB  . LYS A 1 38  ? -1.108  -17.265 -3.026  0.35 97.61  ? 301  LYS A CB  1 
ATOM   253  C  CG  . LYS A 1 38  ? 0.117   -16.359 -2.988  0.35 98.65  ? 301  LYS A CG  1 
ATOM   254  C  CD  . LYS A 1 38  ? 0.362   -15.736 -1.625  0.35 99.84  ? 301  LYS A CD  1 
ATOM   255  C  CE  . LYS A 1 38  ? 0.937   -14.335 -1.685  0.35 101.49 ? 301  LYS A CE  1 
ATOM   256  N  NZ  . LYS A 1 38  ? 2.339   -14.329 -2.167  0.35 102.25 ? 301  LYS A NZ  1 
ATOM   257  N  N   . THR A 1 39  ? -3.309  -17.109 -5.228  0.35 96.40  ? 302  THR A N   1 
ATOM   258  C  CA  . THR A 1 39  ? -3.703  -16.918 -6.653  0.35 93.71  ? 302  THR A CA  1 
ATOM   259  C  C   . THR A 1 39  ? -5.182  -16.513 -6.725  0.35 90.39  ? 302  THR A C   1 
ATOM   260  O  O   . THR A 1 39  ? -5.524  -15.708 -7.613  0.35 85.57  ? 302  THR A O   1 
ATOM   261  C  CB  . THR A 1 39  ? -3.403  -18.169 -7.491  0.35 92.27  ? 302  THR A CB  1 
ATOM   262  O  OG1 . THR A 1 39  ? -4.368  -19.170 -7.170  0.35 93.08  ? 302  THR A OG1 1 
ATOM   263  C  CG2 . THR A 1 39  ? -2.006  -18.708 -7.271  0.35 92.18  ? 302  THR A CG2 1 
ATOM   264  N  N   . TRP A 1 40  ? -6.018  -17.063 -5.836  0.35 89.07  ? 303  TRP A N   1 
ATOM   265  C  CA  . TRP A 1 40  ? -7.436  -16.657 -5.632  0.35 87.59  ? 303  TRP A CA  1 
ATOM   266  C  C   . TRP A 1 40  ? -7.480  -15.336 -4.854  0.35 87.62  ? 303  TRP A C   1 
ATOM   267  O  O   . TRP A 1 40  ? -6.581  -15.116 -4.020  0.35 89.83  ? 303  TRP A O   1 
ATOM   268  C  CB  . TRP A 1 40  ? -8.218  -17.751 -4.894  0.35 87.02  ? 303  TRP A CB  1 
ATOM   269  C  CG  . TRP A 1 40  ? -8.433  -19.009 -5.676  0.35 86.44  ? 303  TRP A CG  1 
ATOM   270  C  CD1 . TRP A 1 40  ? -7.553  -20.039 -5.839  0.35 86.80  ? 303  TRP A CD1 1 
ATOM   271  C  CD2 . TRP A 1 40  ? -9.628  -19.390 -6.381  0.35 85.84  ? 303  TRP A CD2 1 
ATOM   272  N  NE1 . TRP A 1 40  ? -8.111  -21.026 -6.605  0.35 86.64  ? 303  TRP A NE1 1 
ATOM   273  C  CE2 . TRP A 1 40  ? -9.384  -20.658 -6.951  0.35 86.71  ? 303  TRP A CE2 1 
ATOM   274  C  CE3 . TRP A 1 40  ? -10.873 -18.784 -6.591  0.35 84.52  ? 303  TRP A CE3 1 
ATOM   275  C  CZ2 . TRP A 1 40  ? -10.341 -21.325 -7.716  0.35 86.41  ? 303  TRP A CZ2 1 
ATOM   276  C  CZ3 . TRP A 1 40  ? -11.817 -19.445 -7.346  0.35 85.55  ? 303  TRP A CZ3 1 
ATOM   277  C  CH2 . TRP A 1 40  ? -11.552 -20.698 -7.899  0.35 85.35  ? 303  TRP A CH2 1 
ATOM   278  N  N   . ALA A 1 41  ? -8.495  -14.504 -5.116  0.35 87.84  ? 304  ALA A N   1 
ATOM   279  C  CA  . ALA A 1 41  ? -8.761  -13.222 -4.418  0.35 87.36  ? 304  ALA A CA  1 
ATOM   280  C  C   . ALA A 1 41  ? -9.819  -13.448 -3.331  0.35 88.15  ? 304  ALA A C   1 
ATOM   281  O  O   . ALA A 1 41  ? -10.990 -13.670 -3.687  0.35 87.32  ? 304  ALA A O   1 
ATOM   282  C  CB  . ALA A 1 41  ? -9.200  -12.170 -5.407  0.35 84.48  ? 304  ALA A CB  1 
ATOM   283  N  N   . TYR A 1 42  ? -9.407  -13.395 -2.059  0.35 91.32  ? 305  TYR A N   1 
ATOM   284  C  CA  . TYR A 1 42  ? -10.254 -13.630 -0.858  0.35 92.20  ? 305  TYR A CA  1 
ATOM   285  C  C   . TYR A 1 42  ? -11.017 -12.348 -0.502  0.35 93.04  ? 305  TYR A C   1 
ATOM   286  O  O   . TYR A 1 42  ? -10.388 -11.270 -0.463  0.35 96.49  ? 305  TYR A O   1 
ATOM   287  C  CB  . TYR A 1 42  ? -9.393  -14.096 0.320   0.35 92.16  ? 305  TYR A CB  1 
ATOM   288  C  CG  . TYR A 1 42  ? -10.126 -14.178 1.634   0.35 91.63  ? 305  TYR A CG  1 
ATOM   289  C  CD1 . TYR A 1 42  ? -10.974 -15.237 1.911   0.35 91.57  ? 305  TYR A CD1 1 
ATOM   290  C  CD2 . TYR A 1 42  ? -9.974  -13.196 2.600   0.35 92.47  ? 305  TYR A CD2 1 
ATOM   291  C  CE1 . TYR A 1 42  ? -11.652 -15.321 3.116   0.35 92.59  ? 305  TYR A CE1 1 
ATOM   292  C  CE2 . TYR A 1 42  ? -10.646 -13.264 3.810   0.35 92.79  ? 305  TYR A CE2 1 
ATOM   293  C  CZ  . TYR A 1 42  ? -11.488 -14.331 4.069   0.35 93.11  ? 305  TYR A CZ  1 
ATOM   294  O  OH  . TYR A 1 42  ? -12.155 -14.405 5.257   0.35 95.34  ? 305  TYR A OH  1 
ATOM   295  N  N   . HIS A 1 43  ? -12.323 -12.473 -0.234  0.35 90.95  ? 306  HIS A N   1 
ATOM   296  C  CA  . HIS A 1 43  ? -13.258 -11.340 0.019   0.35 88.54  ? 306  HIS A CA  1 
ATOM   297  C  C   . HIS A 1 43  ? -13.790 -11.374 1.459   0.35 88.09  ? 306  HIS A C   1 
ATOM   298  O  O   . HIS A 1 43  ? -13.867 -10.291 2.069   0.35 92.15  ? 306  HIS A O   1 
ATOM   299  C  CB  . HIS A 1 43  ? -14.387 -11.340 -1.021  0.35 85.01  ? 306  HIS A CB  1 
ATOM   300  C  CG  . HIS A 1 43  ? -13.946 -10.879 -2.369  0.35 81.96  ? 306  HIS A CG  1 
ATOM   301  N  ND1 . HIS A 1 43  ? -13.619 -11.760 -3.382  0.35 80.11  ? 306  HIS A ND1 1 
ATOM   302  C  CD2 . HIS A 1 43  ? -13.764 -9.639  -2.871  0.35 80.09  ? 306  HIS A CD2 1 
ATOM   303  C  CE1 . HIS A 1 43  ? -13.262 -11.080 -4.451  0.35 78.83  ? 306  HIS A CE1 1 
ATOM   304  N  NE2 . HIS A 1 43  ? -13.342 -9.777  -4.165  0.35 79.31  ? 306  HIS A NE2 1 
ATOM   305  N  N   . GLY A 1 44  ? -14.161 -12.552 1.974   0.35 84.34  ? 307  GLY A N   1 
ATOM   306  C  CA  . GLY A 1 44  ? -14.679 -12.711 3.347   0.35 84.91  ? 307  GLY A CA  1 
ATOM   307  C  C   . GLY A 1 44  ? -15.041 -14.151 3.667   0.35 85.10  ? 307  GLY A C   1 
ATOM   308  O  O   . GLY A 1 44  ? -14.809 -15.023 2.807   0.35 86.11  ? 307  GLY A O   1 
ATOM   309  N  N   . SER A 1 45  ? -15.594 -14.386 4.863   0.35 87.52  ? 308  SER A N   1 
ATOM   310  C  CA  . SER A 1 45  ? -15.959 -15.727 5.395   0.35 89.82  ? 308  SER A CA  1 
ATOM   311  C  C   . SER A 1 45  ? -17.237 -15.635 6.238   0.35 90.01  ? 308  SER A C   1 
ATOM   312  O  O   . SER A 1 45  ? -17.570 -14.520 6.676   0.35 90.60  ? 308  SER A O   1 
ATOM   313  C  CB  . SER A 1 45  ? -14.826 -16.315 6.198   0.35 91.82  ? 308  SER A CB  1 
ATOM   314  O  OG  . SER A 1 45  ? -13.674 -16.512 5.391   0.35 92.11  ? 308  SER A OG  1 
ATOM   315  N  N   . TYR A 1 46  ? -17.887 -16.776 6.474   0.35 91.80  ? 309  TYR A N   1 
ATOM   316  C  CA  . TYR A 1 46  ? -19.104 -16.803 7.326   0.35 92.41  ? 309  TYR A CA  1 
ATOM   317  C  C   . TYR A 1 46  ? -19.297 -18.218 7.878   0.35 93.66  ? 309  TYR A C   1 
ATOM   318  O  O   . TYR A 1 46  ? -18.852 -19.181 7.227   0.35 96.14  ? 309  TYR A O   1 
ATOM   319  C  CB  . TYR A 1 46  ? -20.323 -16.298 6.549   0.35 91.83  ? 309  TYR A CB  1 
ATOM   320  C  CG  . TYR A 1 46  ? -20.799 -17.186 5.428   0.35 91.88  ? 309  TYR A CG  1 
ATOM   321  C  CD1 . TYR A 1 46  ? -21.679 -18.226 5.671   0.35 92.58  ? 309  TYR A CD1 1 
ATOM   322  C  CD2 . TYR A 1 46  ? -20.395 -16.972 4.122   0.35 91.29  ? 309  TYR A CD2 1 
ATOM   323  C  CE1 . TYR A 1 46  ? -22.134 -19.040 4.649   0.35 93.66  ? 309  TYR A CE1 1 
ATOM   324  C  CE2 . TYR A 1 46  ? -20.839 -17.777 3.086   0.35 91.37  ? 309  TYR A CE2 1 
ATOM   325  C  CZ  . TYR A 1 46  ? -21.712 -18.817 3.352   0.35 93.33  ? 309  TYR A CZ  1 
ATOM   326  O  OH  . TYR A 1 46  ? -22.157 -19.620 2.343   0.35 91.93  ? 309  TYR A OH  1 
ATOM   327  N  N   . GLU A 1 47  ? -19.945 -18.334 9.037   0.35 95.03  ? 310  GLU A N   1 
ATOM   328  C  CA  . GLU A 1 47  ? -20.135 -19.654 9.692   0.35 97.18  ? 310  GLU A CA  1 
ATOM   329  C  C   . GLU A 1 47  ? -20.827 -20.627 8.738   0.35 99.26  ? 310  GLU A C   1 
ATOM   330  O  O   . GLU A 1 47  ? -21.728 -20.187 8.006   0.35 103.68 ? 310  GLU A O   1 
ATOM   331  C  CB  . GLU A 1 47  ? -20.962 -19.489 10.967  0.35 99.21  ? 310  GLU A CB  1 
ATOM   332  C  CG  . GLU A 1 47  ? -21.396 -20.805 11.588  0.35 98.83  ? 310  GLU A CG  1 
ATOM   333  C  CD  . GLU A 1 47  ? -22.076 -20.667 12.940  0.35 98.74  ? 310  GLU A CD  1 
ATOM   334  O  OE1 . GLU A 1 47  ? -22.736 -21.633 13.369  0.35 97.33  ? 310  GLU A OE1 1 
ATOM   335  O  OE2 . GLU A 1 47  ? -21.937 -19.596 13.563  0.35 96.21  ? 310  GLU A OE2 1 
ATOM   336  N  N   . THR A 1 48  ? -20.423 -21.899 8.766   0.35 100.30 ? 311  THR A N   1 
ATOM   337  C  CA  . THR A 1 48  ? -21.041 -22.945 7.908   0.35 99.25  ? 311  THR A CA  1 
ATOM   338  C  C   . THR A 1 48  ? -20.756 -24.314 8.528   0.35 101.49 ? 311  THR A C   1 
ATOM   339  O  O   . THR A 1 48  ? -20.050 -24.356 9.554   0.35 101.38 ? 311  THR A O   1 
ATOM   340  C  CB  . THR A 1 48  ? -20.518 -22.877 6.469   0.35 100.01 ? 311  THR A CB  1 
ATOM   341  O  OG1 . THR A 1 48  ? -19.198 -22.333 6.508   0.35 101.02 ? 311  THR A OG1 1 
ATOM   342  C  CG2 . THR A 1 48  ? -21.389 -22.039 5.560   0.35 100.73 ? 311  THR A CG2 1 
ATOM   343  N  N   . LYS A 1 49  ? -21.282 -25.383 7.927   0.35 101.88 ? 312  LYS A N   1 
ATOM   344  C  CA  . LYS A 1 49  ? -21.033 -26.759 8.437   0.35 101.19 ? 312  LYS A CA  1 
ATOM   345  C  C   . LYS A 1 49  ? -21.517 -27.775 7.395   0.35 99.86  ? 312  LYS A C   1 
ATOM   346  O  O   . LYS A 1 49  ? -21.583 -28.972 7.745   0.35 96.43  ? 312  LYS A O   1 
ATOM   347  C  CB  . LYS A 1 49  ? -21.738 -26.950 9.782   0.35 103.63 ? 312  LYS A CB  1 
ATOM   348  C  CG  . LYS A 1 49  ? -20.944 -27.720 10.829  0.35 103.29 ? 312  LYS A CG  1 
ATOM   349  C  CD  . LYS A 1 49  ? -21.562 -27.657 12.209  0.35 103.89 ? 312  LYS A CD  1 
ATOM   350  C  CE  . LYS A 1 49  ? -21.740 -26.239 12.708  0.35 104.24 ? 312  LYS A CE  1 
ATOM   351  N  NZ  . LYS A 1 49  ? -22.387 -26.201 14.041  0.35 104.60 ? 312  LYS A NZ  1 
ATOM   352  N  N   . SER A 1 55  ? -19.558 -40.726 0.220   1.00 104.75 ? 318  SER A N   1 
ATOM   353  C  CA  . SER A 1 55  ? -18.484 -41.720 -0.072  1.00 95.34  ? 318  SER A CA  1 
ATOM   354  C  C   . SER A 1 55  ? -19.051 -42.891 -0.897  1.00 87.60  ? 318  SER A C   1 
ATOM   355  O  O   . SER A 1 55  ? -20.294 -42.982 -1.060  1.00 73.52  ? 318  SER A O   1 
ATOM   356  C  CB  . SER A 1 55  ? -17.815 -42.208 1.199   1.00 88.15  ? 318  SER A CB  1 
ATOM   357  O  OG  . SER A 1 55  ? -18.417 -43.405 1.675   1.00 82.89  ? 318  SER A OG  1 
ATOM   358  N  N   . SER A 1 56  ? -18.154 -43.750 -1.392  1.00 79.02  ? 319  SER A N   1 
ATOM   359  C  CA  . SER A 1 56  ? -18.442 -44.858 -2.337  1.00 74.71  ? 319  SER A CA  1 
ATOM   360  C  C   . SER A 1 56  ? -18.886 -46.101 -1.559  1.00 69.09  ? 319  SER A C   1 
ATOM   361  O  O   . SER A 1 56  ? -18.101 -46.603 -0.736  1.00 65.96  ? 319  SER A O   1 
ATOM   362  C  CB  . SER A 1 56  ? -17.239 -45.154 -3.205  1.00 84.39  ? 319  SER A CB  1 
ATOM   363  O  OG  . SER A 1 56  ? -16.247 -45.905 -2.503  1.00 78.26  ? 319  SER A OG  1 
ATOM   364  N  N   . MET A 1 57  ? -20.075 -46.616 -1.876  1.00 55.76  ? 320  MET A N   1 
ATOM   365  C  CA  . MET A 1 57  ? -20.677 -47.818 -1.242  1.00 46.71  ? 320  MET A CA  1 
ATOM   366  C  C   . MET A 1 57  ? -20.450 -49.034 -2.153  1.00 36.85  ? 320  MET A C   1 
ATOM   367  O  O   . MET A 1 57  ? -20.302 -48.844 -3.370  1.00 34.89  ? 320  MET A O   1 
ATOM   368  C  CB  . MET A 1 57  ? -22.165 -47.536 -1.071  1.00 52.78  ? 320  MET A CB  1 
ATOM   369  C  CG  . MET A 1 57  ? -22.421 -46.096 -0.610  1.00 56.37  ? 320  MET A CG  1 
ATOM   370  S  SD  . MET A 1 57  ? -21.640 -45.809 1.002   1.00 54.43  ? 320  MET A SD  1 
ATOM   371  C  CE  . MET A 1 57  ? -22.805 -46.687 2.043   1.00 46.65  ? 320  MET A CE  1 
ATOM   372  N  N   . VAL A 1 58  ? -20.390 -50.246 -1.611  1.00 31.27  ? 321  VAL A N   1 
ATOM   373  C  CA  . VAL A 1 58  ? -20.189 -51.462 -2.454  1.00 32.17  ? 321  VAL A CA  1 
ATOM   374  C  C   . VAL A 1 58  ? -21.541 -51.987 -2.952  1.00 31.00  ? 321  VAL A C   1 
ATOM   375  O  O   . VAL A 1 58  ? -22.461 -52.062 -2.130  1.00 33.28  ? 321  VAL A O   1 
ATOM   376  C  CB  . VAL A 1 58  ? -19.409 -52.557 -1.718  1.00 33.16  ? 321  VAL A CB  1 
ATOM   377  C  CG1 . VAL A 1 58  ? -19.297 -53.827 -2.575  1.00 32.18  ? 321  VAL A CG1 1 
ATOM   378  C  CG2 . VAL A 1 58  ? -18.060 -52.038 -1.313  1.00 36.62  ? 321  VAL A CG2 1 
ATOM   379  N  N   . ASN A 1 59  ? -21.628 -52.306 -4.248  1.00 22.97  ? 322  ASN A N   1 
ATOM   380  C  CA  . ASN A 1 59  ? -22.763 -52.989 -4.908  1.00 23.82  ? 322  ASN A CA  1 
ATOM   381  C  C   . ASN A 1 59  ? -22.688 -54.480 -4.589  1.00 24.96  ? 322  ASN A C   1 
ATOM   382  O  O   . ASN A 1 59  ? -21.832 -55.188 -5.200  1.00 24.33  ? 322  ASN A O   1 
ATOM   383  C  CB  . ASN A 1 59  ? -22.716 -52.757 -6.427  1.00 25.86  ? 322  ASN A CB  1 
ATOM   384  C  CG  . ASN A 1 59  ? -23.905 -53.384 -7.126  1.00 24.37  ? 322  ASN A CG  1 
ATOM   385  O  OD1 . ASN A 1 59  ? -24.329 -54.489 -6.785  1.00 24.99  ? 322  ASN A OD1 1 
ATOM   386  N  ND2 . ASN A 1 59  ? -24.565 -52.609 -7.965  1.00 26.22  ? 322  ASN A ND2 1 
ATOM   387  N  N   . GLY A 1 60  ? -23.514 -54.967 -3.665  1.00 26.58  ? 323  GLY A N   1 
ATOM   388  C  CA  . GLY A 1 60  ? -23.446 -56.348 -3.159  1.00 24.39  ? 323  GLY A CA  1 
ATOM   389  C  C   . GLY A 1 60  ? -23.832 -57.396 -4.215  1.00 26.27  ? 323  GLY A C   1 
ATOM   390  O  O   . GLY A 1 60  ? -23.323 -58.519 -4.216  1.00 25.29  ? 323  GLY A O   1 
ATOM   391  N  N   . VAL A 1 61  ? -24.713 -57.071 -5.126  1.00 24.63  ? 324  VAL A N   1 
ATOM   392  C  CA  . VAL A 1 61  ? -25.063 -58.018 -6.215  1.00 24.97  ? 324  VAL A CA  1 
ATOM   393  C  C   . VAL A 1 61  ? -23.792 -58.300 -7.009  1.00 22.86  ? 324  VAL A C   1 
ATOM   394  O  O   . VAL A 1 61  ? -23.494 -59.482 -7.220  1.00 22.41  ? 324  VAL A O   1 
ATOM   395  C  CB  . VAL A 1 61  ? -26.236 -57.460 -7.044  1.00 25.92  ? 324  VAL A CB  1 
ATOM   396  C  CG1 . VAL A 1 61  ? -26.439 -58.186 -8.354  1.00 24.35  ? 324  VAL A CG1 1 
ATOM   397  C  CG2 . VAL A 1 61  ? -27.499 -57.479 -6.195  1.00 27.11  ? 324  VAL A CG2 1 
ATOM   398  N  N   . VAL A 1 62  ? -23.081 -57.263 -7.483  1.00 25.57  ? 325  VAL A N   1 
ATOM   399  C  CA  . VAL A 1 62  ? -21.866 -57.463 -8.330  1.00 25.46  ? 325  VAL A CA  1 
ATOM   400  C  C   . VAL A 1 62  ? -20.782 -58.147 -7.476  1.00 26.70  ? 325  VAL A C   1 
ATOM   401  O  O   . VAL A 1 62  ? -20.168 -59.092 -7.959  1.00 22.34  ? 325  VAL A O   1 
ATOM   402  C  CB  . VAL A 1 62  ? -21.313 -56.178 -8.958  1.00 24.70  ? 325  VAL A CB  1 
ATOM   403  C  CG1 . VAL A 1 62  ? -20.035 -56.475 -9.699  1.00 22.72  ? 325  VAL A CG1 1 
ATOM   404  C  CG2 . VAL A 1 62  ? -22.314 -55.509 -9.885  1.00 24.85  ? 325  VAL A CG2 1 
ATOM   405  N  N   . ARG A 1 63  ? -20.558 -57.741 -6.234  1.00 23.92  ? 326  ARG A N   1 
ATOM   406  C  CA  . ARG A 1 63  ? -19.467 -58.357 -5.453  1.00 25.11  ? 326  ARG A CA  1 
ATOM   407  C  C   . ARG A 1 63  ? -19.750 -59.865 -5.257  1.00 28.16  ? 326  ARG A C   1 
ATOM   408  O  O   . ARG A 1 63  ? -18.793 -60.694 -5.425  1.00 26.76  ? 326  ARG A O   1 
ATOM   409  C  CB  . ARG A 1 63  ? -19.211 -57.601 -4.150  1.00 23.01  ? 326  ARG A CB  1 
ATOM   410  C  CG  . ARG A 1 63  ? -18.154 -58.265 -3.282  1.00 22.93  ? 326  ARG A CG  1 
ATOM   411  C  CD  . ARG A 1 63  ? -17.459 -57.312 -2.328  1.00 21.50  ? 326  ARG A CD  1 
ATOM   412  N  NE  . ARG A 1 63  ? -18.354 -56.830 -1.301  1.00 22.92  ? 326  ARG A NE  1 
ATOM   413  C  CZ  . ARG A 1 63  ? -17.998 -56.018 -0.289  1.00 26.59  ? 326  ARG A CZ  1 
ATOM   414  N  NH1 . ARG A 1 63  ? -16.728 -55.688 -0.102  1.00 25.04  ? 326  ARG A NH1 1 
ATOM   415  N  NH2 . ARG A 1 63  ? -18.917 -55.556 0.563   1.00 25.69  ? 326  ARG A NH2 1 
ATOM   416  N  N   . LEU A 1 64  ? -20.970 -60.270 -4.894  1.00 27.13  ? 327  LEU A N   1 
ATOM   417  C  CA  . LEU A 1 64  ? -21.245 -61.707 -4.558  1.00 25.82  ? 327  LEU A CA  1 
ATOM   418  C  C   . LEU A 1 64  ? -21.022 -62.536 -5.827  1.00 25.52  ? 327  LEU A C   1 
ATOM   419  O  O   . LEU A 1 64  ? -20.711 -63.713 -5.688  1.00 26.05  ? 327  LEU A O   1 
ATOM   420  C  CB  . LEU A 1 64  ? -22.667 -61.932 -4.021  1.00 24.81  ? 327  LEU A CB  1 
ATOM   421  C  CG  . LEU A 1 64  ? -22.877 -61.594 -2.547  1.00 25.20  ? 327  LEU A CG  1 
ATOM   422  C  CD1 . LEU A 1 64  ? -24.355 -61.719 -2.179  1.00 26.70  ? 327  LEU A CD1 1 
ATOM   423  C  CD2 . LEU A 1 64  ? -22.059 -62.478 -1.622  1.00 24.22  ? 327  LEU A CD2 1 
ATOM   424  N  N   . LEU A 1 65  ? -21.085 -61.927 -7.020  1.00 23.92  ? 328  LEU A N   1 
ATOM   425  C  CA  . LEU A 1 65  ? -20.918 -62.671 -8.310  1.00 25.54  ? 328  LEU A CA  1 
ATOM   426  C  C   . LEU A 1 65  ? -19.511 -62.485 -8.912  1.00 24.61  ? 328  LEU A C   1 
ATOM   427  O  O   . LEU A 1 65  ? -19.281 -63.022 -9.986  1.00 24.21  ? 328  LEU A O   1 
ATOM   428  C  CB  . LEU A 1 65  ? -22.029 -62.275 -9.285  1.00 25.99  ? 328  LEU A CB  1 
ATOM   429  C  CG  . LEU A 1 65  ? -23.423 -62.614 -8.753  1.00 27.04  ? 328  LEU A CG  1 
ATOM   430  C  CD1 . LEU A 1 65  ? -24.534 -61.993 -9.590  1.00 27.54  ? 328  LEU A CD1 1 
ATOM   431  C  CD2 . LEU A 1 65  ? -23.608 -64.102 -8.684  1.00 28.51  ? 328  LEU A CD2 1 
ATOM   432  N  N   . THR A 1 66  ? -18.576 -61.887 -8.167  1.00 22.06  ? 329  THR A N   1 
ATOM   433  C  CA  . THR A 1 66  ? -17.162 -61.722 -8.549  1.00 21.65  ? 329  THR A CA  1 
ATOM   434  C  C   . THR A 1 66  ? -16.255 -62.096 -7.355  1.00 22.10  ? 329  THR A C   1 
ATOM   435  O  O   . THR A 1 66  ? -15.245 -61.419 -7.101  1.00 24.52  ? 329  THR A O   1 
ATOM   436  C  CB  . THR A 1 66  ? -16.907 -60.298 -9.091  1.00 23.07  ? 329  THR A CB  1 
ATOM   437  O  OG1 . THR A 1 66  ? -17.327 -59.300 -8.132  1.00 21.33  ? 329  THR A OG1 1 
ATOM   438  C  CG2 . THR A 1 66  ? -17.586 -60.093 -10.430 1.00 21.65  ? 329  THR A CG2 1 
ATOM   439  N  N   . LYS A 1 67  ? -16.482 -63.223 -6.736  1.00 22.94  ? 330  LYS A N   1 
ATOM   440  C  CA  . LYS A 1 67  ? -15.767 -63.630 -5.493  1.00 23.02  ? 330  LYS A CA  1 
ATOM   441  C  C   . LYS A 1 67  ? -14.257 -63.743 -5.696  1.00 23.54  ? 330  LYS A C   1 
ATOM   442  O  O   . LYS A 1 67  ? -13.533 -63.277 -4.833  1.00 25.08  ? 330  LYS A O   1 
ATOM   443  C  CB  . LYS A 1 67  ? -16.351 -64.936 -4.964  1.00 24.88  ? 330  LYS A CB  1 
ATOM   444  C  CG  . LYS A 1 67  ? -15.808 -65.367 -3.617  1.00 27.53  ? 330  LYS A CG  1 
ATOM   445  C  CD  . LYS A 1 67  ? -16.353 -66.692 -3.192  1.00 30.37  ? 330  LYS A CD  1 
ATOM   446  C  CE  . LYS A 1 67  ? -16.435 -66.783 -1.684  1.00 33.94  ? 330  LYS A CE  1 
ATOM   447  N  NZ  . LYS A 1 67  ? -16.196 -68.175 -1.269  1.00 35.83  ? 330  LYS A NZ  1 
ATOM   448  N  N   . PRO A 1 68  ? -13.679 -64.273 -6.799  1.00 22.49  ? 331  PRO A N   1 
ATOM   449  C  CA  . PRO A 1 68  ? -12.226 -64.333 -6.913  1.00 25.77  ? 331  PRO A CA  1 
ATOM   450  C  C   . PRO A 1 68  ? -11.530 -62.980 -6.668  1.00 28.28  ? 331  PRO A C   1 
ATOM   451  O  O   . PRO A 1 68  ? -10.383 -62.962 -6.164  1.00 22.57  ? 331  PRO A O   1 
ATOM   452  C  CB  . PRO A 1 68  ? -11.960 -64.804 -8.382  1.00 26.50  ? 331  PRO A CB  1 
ATOM   453  C  CG  . PRO A 1 68  ? -13.193 -65.632 -8.688  1.00 26.84  ? 331  PRO A CG  1 
ATOM   454  C  CD  . PRO A 1 68  ? -14.336 -64.908 -7.956  1.00 26.41  ? 331  PRO A CD  1 
ATOM   455  N  N   . TRP A 1 69  ? -12.210 -61.867 -7.004  1.00 27.13  ? 332  TRP A N   1 
ATOM   456  C  CA  . TRP A 1 69  ? -11.650 -60.497 -6.906  1.00 24.94  ? 332  TRP A CA  1 
ATOM   457  C  C   . TRP A 1 69  ? -11.695 -59.971 -5.469  1.00 26.57  ? 332  TRP A C   1 
ATOM   458  O  O   . TRP A 1 69  ? -11.100 -58.930 -5.229  1.00 25.40  ? 332  TRP A O   1 
ATOM   459  C  CB  . TRP A 1 69  ? -12.337 -59.597 -7.937  1.00 25.76  ? 332  TRP A CB  1 
ATOM   460  C  CG  . TRP A 1 69  ? -11.935 -59.992 -9.319  1.00 24.03  ? 332  TRP A CG  1 
ATOM   461  C  CD1 . TRP A 1 69  ? -10.836 -59.541 -9.982  1.00 25.58  ? 332  TRP A CD1 1 
ATOM   462  C  CD2 . TRP A 1 69  ? -12.526 -61.001 -10.151 1.00 23.83  ? 332  TRP A CD2 1 
ATOM   463  N  NE1 . TRP A 1 69  ? -10.714 -60.179 -11.188 1.00 26.41  ? 332  TRP A NE1 1 
ATOM   464  C  CE2 . TRP A 1 69  ? -11.731 -61.086 -11.314 1.00 25.69  ? 332  TRP A CE2 1 
ATOM   465  C  CE3 . TRP A 1 69  ? -13.633 -61.847 -10.040 1.00 27.11  ? 332  TRP A CE3 1 
ATOM   466  C  CZ2 . TRP A 1 69  ? -12.023 -61.952 -12.362 1.00 27.63  ? 332  TRP A CZ2 1 
ATOM   467  C  CZ3 . TRP A 1 69  ? -13.926 -62.705 -11.081 1.00 25.36  ? 332  TRP A CZ3 1 
ATOM   468  C  CH2 . TRP A 1 69  ? -13.117 -62.773 -12.208 1.00 27.84  ? 332  TRP A CH2 1 
ATOM   469  N  N   . ASP A 1 70  ? -12.304 -60.683 -4.520  1.00 25.12  ? 333  ASP A N   1 
ATOM   470  C  CA  . ASP A 1 70  ? -12.351 -60.206 -3.111  1.00 24.51  ? 333  ASP A CA  1 
ATOM   471  C  C   . ASP A 1 70  ? -10.936 -60.166 -2.498  1.00 25.92  ? 333  ASP A C   1 
ATOM   472  O  O   . ASP A 1 70  ? -10.784 -59.583 -1.386  1.00 28.42  ? 333  ASP A O   1 
ATOM   473  C  CB  . ASP A 1 70  ? -13.253 -61.120 -2.271  1.00 25.50  ? 333  ASP A CB  1 
ATOM   474  C  CG  . ASP A 1 70  ? -14.721 -61.003 -2.609  1.00 24.74  ? 333  ASP A CG  1 
ATOM   475  O  OD1 . ASP A 1 70  ? -15.065 -60.098 -3.411  1.00 24.13  ? 333  ASP A OD1 1 
ATOM   476  O  OD2 . ASP A 1 70  ? -15.507 -61.798 -2.058  1.00 24.84  ? 333  ASP A OD2 1 
ATOM   477  N  N   . ILE A 1 71  ? -9.952  -60.828 -3.125  1.00 28.88  ? 334  ILE A N   1 
ATOM   478  C  CA  . ILE A 1 71  ? -8.563  -60.953 -2.593  1.00 25.17  ? 334  ILE A CA  1 
ATOM   479  C  C   . ILE A 1 71  ? -7.574  -60.215 -3.503  1.00 27.32  ? 334  ILE A C   1 
ATOM   480  O  O   . ILE A 1 71  ? -6.335  -60.355 -3.263  1.00 28.54  ? 334  ILE A O   1 
ATOM   481  C  CB  . ILE A 1 71  ? -8.148  -62.422 -2.361  1.00 26.90  ? 334  ILE A CB  1 
ATOM   482  C  CG1 . ILE A 1 71  ? -8.176  -63.288 -3.629  1.00 28.34  ? 334  ILE A CG1 1 
ATOM   483  C  CG2 . ILE A 1 71  ? -8.981  -63.071 -1.275  1.00 26.86  ? 334  ILE A CG2 1 
ATOM   484  C  CD1 . ILE A 1 71  ? -7.490  -64.604 -3.450  1.00 31.52  ? 334  ILE A CD1 1 
ATOM   485  N  N   . ILE A 1 72  ? -8.047  -59.460 -4.498  1.00 26.95  ? 335  ILE A N   1 
ATOM   486  C  CA  . ILE A 1 72  ? -7.193  -58.683 -5.443  1.00 25.81  ? 335  ILE A CA  1 
ATOM   487  C  C   . ILE A 1 72  ? -7.180  -57.235 -4.976  1.00 28.61  ? 335  ILE A C   1 
ATOM   488  O  O   . ILE A 1 72  ? -8.141  -56.488 -5.228  1.00 29.43  ? 335  ILE A O   1 
ATOM   489  C  CB  . ILE A 1 72  ? -7.732  -58.762 -6.881  1.00 31.07  ? 335  ILE A CB  1 
ATOM   490  C  CG1 . ILE A 1 72  ? -7.888  -60.203 -7.379  1.00 34.04  ? 335  ILE A CG1 1 
ATOM   491  C  CG2 . ILE A 1 72  ? -6.904  -57.886 -7.826  1.00 30.19  ? 335  ILE A CG2 1 
ATOM   492  C  CD1 . ILE A 1 72  ? -6.622  -60.922 -7.657  1.00 35.95  ? 335  ILE A CD1 1 
ATOM   493  N  N   . PRO A 1 73  ? -6.094  -56.766 -4.314  1.00 30.36  ? 336  PRO A N   1 
ATOM   494  C  CA  . PRO A 1 73  ? -6.027  -55.394 -3.820  1.00 32.12  ? 336  PRO A CA  1 
ATOM   495  C  C   . PRO A 1 73  ? -6.334  -54.303 -4.861  1.00 30.95  ? 336  PRO A C   1 
ATOM   496  O  O   . PRO A 1 73  ? -7.010  -53.346 -4.515  1.00 27.65  ? 336  PRO A O   1 
ATOM   497  C  CB  . PRO A 1 73  ? -4.555  -55.279 -3.380  1.00 37.76  ? 336  PRO A CB  1 
ATOM   498  C  CG  . PRO A 1 73  ? -4.260  -56.682 -2.916  1.00 39.14  ? 336  PRO A CG  1 
ATOM   499  C  CD  . PRO A 1 73  ? -4.873  -57.527 -4.026  1.00 32.32  ? 336  PRO A CD  1 
ATOM   500  N  N   . MET A 1 74  ? -5.947  -54.467 -6.129  1.00 31.90  ? 337  MET A N   1 
ATOM   501  C  CA  . MET A 1 74  ? -6.261  -53.405 -7.126  1.00 32.11  ? 337  MET A CA  1 
ATOM   502  C  C   . MET A 1 74  ? -7.787  -53.249 -7.225  1.00 33.56  ? 337  MET A C   1 
ATOM   503  O  O   . MET A 1 74  ? -8.235  -52.134 -7.479  1.00 35.34  ? 337  MET A O   1 
ATOM   504  C  CB  . MET A 1 74  ? -5.665  -53.717 -8.504  1.00 42.07  ? 337  MET A CB  1 
ATOM   505  C  CG  . MET A 1 74  ? -4.132  -53.676 -8.497  1.00 52.88  ? 337  MET A CG  1 
ATOM   506  S  SD  . MET A 1 74  ? -3.508  -52.021 -7.995  1.00 61.78  ? 337  MET A SD  1 
ATOM   507  C  CE  . MET A 1 74  ? -4.446  -50.989 -9.127  1.00 61.01  ? 337  MET A CE  1 
ATOM   508  N  N   . VAL A 1 75  ? -8.566  -54.316 -7.020  1.00 27.38  ? 338  VAL A N   1 
ATOM   509  C  CA  . VAL A 1 75  ? -10.063 -54.219 -7.044  1.00 26.56  ? 338  VAL A CA  1 
ATOM   510  C  C   . VAL A 1 75  ? -10.562 -53.670 -5.707  1.00 25.25  ? 338  VAL A C   1 
ATOM   511  O  O   . VAL A 1 75  ? -11.347 -52.770 -5.729  1.00 30.19  ? 338  VAL A O   1 
ATOM   512  C  CB  . VAL A 1 75  ? -10.719 -55.575 -7.376  1.00 24.23  ? 338  VAL A CB  1 
ATOM   513  C  CG1 . VAL A 1 75  ? -12.204 -55.581 -7.025  1.00 24.44  ? 338  VAL A CG1 1 
ATOM   514  C  CG2 . VAL A 1 75  ? -10.512 -55.926 -8.854  1.00 23.83  ? 338  VAL A CG2 1 
ATOM   515  N  N   . THR A 1 76  ? -10.176 -54.264 -4.592  1.00 27.07  ? 339  THR A N   1 
ATOM   516  C  CA  . THR A 1 76  ? -10.791 -54.002 -3.276  1.00 30.53  ? 339  THR A CA  1 
ATOM   517  C  C   . THR A 1 76  ? -10.438 -52.606 -2.804  1.00 32.68  ? 339  THR A C   1 
ATOM   518  O  O   . THR A 1 76  ? -11.305 -51.984 -2.099  1.00 34.98  ? 339  THR A O   1 
ATOM   519  C  CB  . THR A 1 76  ? -10.409 -55.068 -2.239  1.00 30.14  ? 339  THR A CB  1 
ATOM   520  O  OG1 . THR A 1 76  ? -8.989  -55.124 -2.044  1.00 32.41  ? 339  THR A OG1 1 
ATOM   521  C  CG2 . THR A 1 76  ? -10.896 -56.421 -2.694  1.00 32.00  ? 339  THR A CG2 1 
ATOM   522  N  N   . GLN A 1 77  ? -9.260  -52.100 -3.164  1.00 33.51  ? 340  GLN A N   1 
ATOM   523  C  CA  . GLN A 1 77  ? -8.813  -50.766 -2.647  1.00 38.58  ? 340  GLN A CA  1 
ATOM   524  C  C   . GLN A 1 77  ? -9.589  -49.677 -3.356  1.00 34.26  ? 340  GLN A C   1 
ATOM   525  O  O   . GLN A 1 77  ? -9.708  -48.613 -2.750  1.00 30.10  ? 340  GLN A O   1 
ATOM   526  C  CB  . GLN A 1 77  ? -7.326  -50.465 -2.830  1.00 38.92  ? 340  GLN A CB  1 
ATOM   527  C  CG  . GLN A 1 77  ? -6.432  -51.562 -2.308  1.00 50.54  ? 340  GLN A CG  1 
ATOM   528  C  CD  . GLN A 1 77  ? -5.944  -51.379 -0.897  1.00 63.60  ? 340  GLN A CD  1 
ATOM   529  O  OE1 . GLN A 1 77  ? -6.550  -50.653 -0.109  1.00 68.62  ? 340  GLN A OE1 1 
ATOM   530  N  NE2 . GLN A 1 77  ? -4.854  -52.075 -0.572  1.00 64.99  ? 340  GLN A NE2 1 
ATOM   531  N  N   . MET A 1 78  ? -10.101 -49.944 -4.566  1.00 30.16  ? 341  MET A N   1 
ATOM   532  C  CA  . MET A 1 78  ? -10.859 -48.920 -5.319  1.00 31.71  ? 341  MET A CA  1 
ATOM   533  C  C   . MET A 1 78  ? -12.082 -48.481 -4.527  1.00 33.31  ? 341  MET A C   1 
ATOM   534  O  O   . MET A 1 78  ? -12.511 -47.361 -4.758  1.00 32.66  ? 341  MET A O   1 
ATOM   535  C  CB  . MET A 1 78  ? -11.343 -49.366 -6.689  1.00 33.19  ? 341  MET A CB  1 
ATOM   536  C  CG  . MET A 1 78  ? -10.212 -49.523 -7.678  1.00 42.56  ? 341  MET A CG  1 
ATOM   537  S  SD  . MET A 1 78  ? -10.870 -49.824 -9.353  1.00 46.15  ? 341  MET A SD  1 
ATOM   538  C  CE  . MET A 1 78  ? -12.201 -48.638 -9.287  1.00 35.53  ? 341  MET A CE  1 
ATOM   539  N  N   . ALA A 1 79  ? -12.636 -49.316 -3.638  1.00 34.53  ? 342  ALA A N   1 
ATOM   540  C  CA  . ALA A 1 79  ? -13.888 -48.978 -2.924  1.00 33.77  ? 342  ALA A CA  1 
ATOM   541  C  C   . ALA A 1 79  ? -13.611 -48.262 -1.599  1.00 34.05  ? 342  ALA A C   1 
ATOM   542  O  O   . ALA A 1 79  ? -14.574 -47.852 -1.016  1.00 35.81  ? 342  ALA A O   1 
ATOM   543  C  CB  . ALA A 1 79  ? -14.721 -50.230 -2.700  1.00 36.26  ? 342  ALA A CB  1 
ATOM   544  N  N   . MET A 1 80  ? -12.374 -48.132 -1.129  1.00 37.69  ? 343  MET A N   1 
ATOM   545  C  CA  . MET A 1 80  ? -12.071 -47.473 0.180   1.00 46.85  ? 343  MET A CA  1 
ATOM   546  C  C   . MET A 1 80  ? -11.929 -45.948 0.027   1.00 57.49  ? 343  MET A C   1 
ATOM   547  O  O   . MET A 1 80  ? -11.578 -45.503 -1.076  1.00 61.50  ? 343  MET A O   1 
ATOM   548  C  CB  . MET A 1 80  ? -10.766 -48.016 0.774   1.00 45.76  ? 343  MET A CB  1 
ATOM   549  C  CG  . MET A 1 80  ? -10.721 -49.526 0.860   1.00 48.72  ? 343  MET A CG  1 
ATOM   550  S  SD  . MET A 1 80  ? -12.050 -50.287 1.888   1.00 47.76  ? 343  MET A SD  1 
ATOM   551  C  CE  . MET A 1 80  ? -11.606 -49.639 3.504   1.00 46.04  ? 343  MET A CE  1 
ATOM   552  N  N   . THR A 1 81  ? -12.174 -45.183 1.107   1.00 73.05  ? 344  THR A N   1 
ATOM   553  C  CA  . THR A 1 81  ? -11.608 -43.827 1.337   1.00 69.54  ? 344  THR A CA  1 
ATOM   554  C  C   . THR A 1 81  ? -12.645 -42.716 1.340   1.00 58.21  ? 344  THR A C   1 
ATOM   555  O  O   . THR A 1 81  ? -13.835 -43.036 1.584   1.00 62.07  ? 344  THR A O   1 
ATOM   556  N  N   . LYS A 1 93  ? -6.128  -30.046 -4.689  0.35 95.15  ? 356  LYS A N   1 
ATOM   557  C  CA  . LYS A 1 93  ? -6.546  -28.704 -4.197  0.35 98.55  ? 356  LYS A CA  1 
ATOM   558  C  C   . LYS A 1 93  ? -5.313  -27.823 -3.929  0.35 101.28 ? 356  LYS A C   1 
ATOM   559  O  O   . LYS A 1 93  ? -5.506  -26.658 -3.528  0.35 104.43 ? 356  LYS A O   1 
ATOM   560  C  CB  . LYS A 1 93  ? -7.409  -28.855 -2.939  0.35 98.13  ? 356  LYS A CB  1 
ATOM   561  C  CG  . LYS A 1 93  ? -8.736  -28.103 -2.960  0.35 96.02  ? 356  LYS A CG  1 
ATOM   562  C  CD  . LYS A 1 93  ? -8.610  -26.598 -2.823  0.35 95.34  ? 356  LYS A CD  1 
ATOM   563  C  CE  . LYS A 1 93  ? -8.302  -26.137 -1.413  0.35 92.54  ? 356  LYS A CE  1 
ATOM   564  N  NZ  . LYS A 1 93  ? -9.496  -26.206 -0.539  0.35 91.89  ? 356  LYS A NZ  1 
ATOM   565  N  N   . GLU A 1 94  ? -4.100  -28.355 -4.130  0.35 101.92 ? 357  GLU A N   1 
ATOM   566  C  CA  . GLU A 1 94  ? -2.817  -27.600 -4.073  0.35 102.35 ? 357  GLU A CA  1 
ATOM   567  C  C   . GLU A 1 94  ? -2.345  -27.310 -5.506  0.35 101.65 ? 357  GLU A C   1 
ATOM   568  O  O   . GLU A 1 94  ? -1.213  -26.809 -5.666  0.35 100.69 ? 357  GLU A O   1 
ATOM   569  C  CB  . GLU A 1 94  ? -1.781  -28.388 -3.265  0.35 101.96 ? 357  GLU A CB  1 
ATOM   570  C  CG  . GLU A 1 94  ? -2.070  -28.427 -1.770  0.35 100.72 ? 357  GLU A CG  1 
ATOM   571  C  CD  . GLU A 1 94  ? -3.360  -29.121 -1.357  0.35 98.36  ? 357  GLU A CD  1 
ATOM   572  O  OE1 . GLU A 1 94  ? -4.019  -28.631 -0.416  0.35 94.46  ? 357  GLU A OE1 1 
ATOM   573  O  OE2 . GLU A 1 94  ? -3.703  -30.154 -1.968  0.35 96.45  ? 357  GLU A OE2 1 
ATOM   574  N  N   . LYS A 1 95  ? -3.190  -27.616 -6.500  0.35 102.03 ? 358  LYS A N   1 
ATOM   575  C  CA  . LYS A 1 95  ? -2.983  -27.318 -7.945  0.35 101.37 ? 358  LYS A CA  1 
ATOM   576  C  C   . LYS A 1 95  ? -3.982  -26.242 -8.403  0.35 100.64 ? 358  LYS A C   1 
ATOM   577  O  O   . LYS A 1 95  ? -3.618  -25.450 -9.296  0.35 96.54  ? 358  LYS A O   1 
ATOM   578  C  CB  . LYS A 1 95  ? -3.099  -28.610 -8.765  0.35 100.17 ? 358  LYS A CB  1 
ATOM   579  C  CG  . LYS A 1 95  ? -3.701  -28.469 -10.159 0.35 98.81  ? 358  LYS A CG  1 
ATOM   580  C  CD  . LYS A 1 95  ? -3.236  -29.528 -11.132 0.35 96.41  ? 358  LYS A CD  1 
ATOM   581  C  CE  . LYS A 1 95  ? -1.987  -29.121 -11.885 0.35 95.05  ? 358  LYS A CE  1 
ATOM   582  N  NZ  . LYS A 1 95  ? -1.448  -30.238 -12.696 0.35 94.24  ? 358  LYS A NZ  1 
ATOM   583  N  N   . VAL A 1 96  ? -5.191  -26.214 -7.830  0.35 101.56 ? 359  VAL A N   1 
ATOM   584  C  CA  . VAL A 1 96  ? -6.250  -25.211 -8.162  0.35 103.40 ? 359  VAL A CA  1 
ATOM   585  C  C   . VAL A 1 96  ? -5.761  -23.810 -7.758  0.35 102.60 ? 359  VAL A C   1 
ATOM   586  O  O   . VAL A 1 96  ? -6.128  -22.843 -8.455  0.35 103.11 ? 359  VAL A O   1 
ATOM   587  C  CB  . VAL A 1 96  ? -7.605  -25.567 -7.515  0.35 103.68 ? 359  VAL A CB  1 
ATOM   588  C  CG1 . VAL A 1 96  ? -7.600  -25.370 -6.006  0.35 105.02 ? 359  VAL A CG1 1 
ATOM   589  C  CG2 . VAL A 1 96  ? -8.753  -24.794 -8.148  0.35 102.87 ? 359  VAL A CG2 1 
ATOM   590  N  N   . ASP A 1 97  ? -4.953  -23.711 -6.693  1.00 100.32 ? 360  ASP A N   1 
ATOM   591  C  CA  . ASP A 1 97  ? -4.331  -22.429 -6.238  1.00 96.68  ? 360  ASP A CA  1 
ATOM   592  C  C   . ASP A 1 97  ? -2.949  -22.260 -6.910  1.00 99.12  ? 360  ASP A C   1 
ATOM   593  O  O   . ASP A 1 97  ? -1.945  -22.091 -6.179  1.00 103.61 ? 360  ASP A O   1 
ATOM   594  C  CB  . ASP A 1 97  ? -4.284  -22.360 -4.701  1.00 93.38  ? 360  ASP A CB  1 
ATOM   595  C  CG  . ASP A 1 97  ? -4.297  -20.967 -4.063  1.00 90.19  ? 360  ASP A CG  1 
ATOM   596  O  OD1 . ASP A 1 97  ? -4.074  -19.970 -4.769  1.00 84.05  ? 360  ASP A OD1 1 
ATOM   597  O  OD2 . ASP A 1 97  ? -4.528  -20.886 -2.840  1.00 89.77  ? 360  ASP A OD2 1 
ATOM   598  N  N   . THR A 1 98  ? -2.897  -22.277 -8.252  1.00 92.08  ? 361  THR A N   1 
ATOM   599  C  CA  . THR A 1 98  ? -1.697  -22.000 -9.096  1.00 97.53  ? 361  THR A CA  1 
ATOM   600  C  C   . THR A 1 98  ? -2.067  -20.891 -10.083 1.00 99.41  ? 361  THR A C   1 
ATOM   601  O  O   . THR A 1 98  ? -3.267  -20.703 -10.347 1.00 99.02  ? 361  THR A O   1 
ATOM   602  C  CB  . THR A 1 98  ? -1.199  -23.244 -9.845  1.00 96.32  ? 361  THR A CB  1 
ATOM   603  O  OG1 . THR A 1 98  ? -2.290  -23.757 -10.614 1.00 93.58  ? 361  THR A OG1 1 
ATOM   604  C  CG2 . THR A 1 98  ? -0.651  -24.311 -8.921  1.00 95.37  ? 361  THR A CG2 1 
ATOM   605  N  N   . ARG A 1 99  ? -1.050  -20.199 -10.609 0.35 101.34 ? 362  ARG A N   1 
ATOM   606  C  CA  . ARG A 1 99  ? -1.183  -19.005 -11.486 0.35 102.89 ? 362  ARG A CA  1 
ATOM   607  C  C   . ARG A 1 99  ? -0.437  -19.259 -12.804 0.35 101.16 ? 362  ARG A C   1 
ATOM   608  O  O   . ARG A 1 99  ? 0.776   -19.548 -12.745 0.35 103.83 ? 362  ARG A O   1 
ATOM   609  C  CB  . ARG A 1 99  ? -0.626  -17.774 -10.761 0.35 105.43 ? 362  ARG A CB  1 
ATOM   610  C  CG  . ARG A 1 99  ? -1.399  -16.487 -11.011 0.35 106.55 ? 362  ARG A CG  1 
ATOM   611  C  CD  . ARG A 1 99  ? -0.484  -15.279 -11.086 0.35 108.51 ? 362  ARG A CD  1 
ATOM   612  N  NE  . ARG A 1 99  ? 0.277   -15.262 -12.330 0.35 110.74 ? 362  ARG A NE  1 
ATOM   613  C  CZ  . ARG A 1 99  ? 1.135   -14.311 -12.692 0.35 109.18 ? 362  ARG A CZ  1 
ATOM   614  N  NH1 . ARG A 1 99  ? 1.361   -13.273 -11.903 0.35 110.65 ? 362  ARG A NH1 1 
ATOM   615  N  NH2 . ARG A 1 99  ? 1.768   -14.404 -13.849 0.35 107.57 ? 362  ARG A NH2 1 
ATOM   616  N  N   . THR A 1 100 ? -1.146  -19.156 -13.934 0.35 97.03  ? 363  THR A N   1 
ATOM   617  C  CA  . THR A 1 100 ? -0.520  -19.348 -15.268 0.35 93.06  ? 363  THR A CA  1 
ATOM   618  C  C   . THR A 1 100 ? -0.087  -17.987 -15.811 0.35 90.46  ? 363  THR A C   1 
ATOM   619  O  O   . THR A 1 100 ? -0.768  -16.995 -15.501 0.35 92.57  ? 363  THR A O   1 
ATOM   620  C  CB  . THR A 1 100 ? -1.485  -20.046 -16.232 0.35 94.68  ? 363  THR A CB  1 
ATOM   621  O  OG1 . THR A 1 100 ? -1.967  -21.231 -15.598 0.35 95.27  ? 363  THR A OG1 1 
ATOM   622  C  CG2 . THR A 1 100 ? -0.844  -20.397 -17.557 0.35 94.12  ? 363  THR A CG2 1 
ATOM   623  N  N   . GLN A 1 101 ? 0.996   -17.946 -16.589 0.35 89.82  ? 364  GLN A N   1 
ATOM   624  C  CA  . GLN A 1 101 ? 1.532   -16.658 -17.104 0.35 88.22  ? 364  GLN A CA  1 
ATOM   625  C  C   . GLN A 1 101 ? 0.844   -16.278 -18.417 0.35 83.17  ? 364  GLN A C   1 
ATOM   626  O  O   . GLN A 1 101 ? 0.323   -17.182 -19.093 0.35 80.32  ? 364  GLN A O   1 
ATOM   627  C  CB  . GLN A 1 101 ? 3.043   -16.771 -17.316 0.35 90.26  ? 364  GLN A CB  1 
ATOM   628  C  CG  . GLN A 1 101 ? 3.655   -15.566 -18.015 0.35 93.68  ? 364  GLN A CG  1 
ATOM   629  C  CD  . GLN A 1 101 ? 5.019   -15.865 -18.588 0.35 94.94  ? 364  GLN A CD  1 
ATOM   630  O  OE1 . GLN A 1 101 ? 5.599   -16.920 -18.345 0.35 94.50  ? 364  GLN A OE1 1 
ATOM   631  N  NE2 . GLN A 1 101 ? 5.542   -14.928 -19.361 0.35 94.94  ? 364  GLN A NE2 1 
ATOM   632  N  N   . GLU A 1 102 ? 0.851   -14.988 -18.759 0.35 80.66  ? 365  GLU A N   1 
ATOM   633  C  CA  . GLU A 1 102 ? 0.276   -14.531 -20.050 0.35 77.26  ? 365  GLU A CA  1 
ATOM   634  C  C   . GLU A 1 102 ? 1.166   -15.031 -21.190 0.35 70.52  ? 365  GLU A C   1 
ATOM   635  O  O   . GLU A 1 102 ? 2.397   -14.891 -21.087 0.35 67.30  ? 365  GLU A O   1 
ATOM   636  C  CB  . GLU A 1 102 ? 0.187   -13.005 -20.071 0.35 80.83  ? 365  GLU A CB  1 
ATOM   637  C  CG  . GLU A 1 102 ? -0.392  -12.443 -21.356 0.35 83.27  ? 365  GLU A CG  1 
ATOM   638  C  CD  . GLU A 1 102 ? -1.907  -12.498 -21.446 0.35 85.29  ? 365  GLU A CD  1 
ATOM   639  O  OE1 . GLU A 1 102 ? -2.450  -12.098 -22.493 0.35 86.75  ? 365  GLU A OE1 1 
ATOM   640  O  OE2 . GLU A 1 102 ? -2.540  -12.932 -20.464 0.35 86.13  ? 365  GLU A OE2 1 
ATOM   641  N  N   . PRO A 1 103 ? 0.596   -15.603 -22.270 0.35 64.11  ? 366  PRO A N   1 
ATOM   642  C  CA  . PRO A 1 103 ? 1.390   -16.051 -23.410 0.35 61.70  ? 366  PRO A CA  1 
ATOM   643  C  C   . PRO A 1 103 ? 2.064   -14.881 -24.138 0.35 58.70  ? 366  PRO A C   1 
ATOM   644  O  O   . PRO A 1 103 ? 1.613   -13.766 -23.983 0.35 57.77  ? 366  PRO A O   1 
ATOM   645  C  CB  . PRO A 1 103 ? 0.354   -16.700 -24.340 0.35 62.39  ? 366  PRO A CB  1 
ATOM   646  C  CG  . PRO A 1 103 ? -0.821  -17.010 -23.441 0.35 63.64  ? 366  PRO A CG  1 
ATOM   647  C  CD  . PRO A 1 103 ? -0.829  -15.885 -22.430 0.35 63.72  ? 366  PRO A CD  1 
ATOM   648  N  N   . LYS A 1 104 ? 3.117   -15.167 -24.907 0.35 58.63  ? 367  LYS A N   1 
ATOM   649  C  CA  . LYS A 1 104 ? 3.823   -14.117 -25.691 0.35 57.68  ? 367  LYS A CA  1 
ATOM   650  C  C   . LYS A 1 104 ? 2.894   -13.570 -26.776 0.35 54.96  ? 367  LYS A C   1 
ATOM   651  O  O   . LYS A 1 104 ? 1.834   -14.176 -27.004 0.35 53.16  ? 367  LYS A O   1 
ATOM   652  C  CB  . LYS A 1 104 ? 5.099   -14.679 -26.326 0.35 59.23  ? 367  LYS A CB  1 
ATOM   653  C  CG  . LYS A 1 104 ? 6.050   -15.383 -25.368 0.35 59.78  ? 367  LYS A CG  1 
ATOM   654  C  CD  . LYS A 1 104 ? 6.357   -14.566 -24.135 0.35 60.24  ? 367  LYS A CD  1 
ATOM   655  C  CE  . LYS A 1 104 ? 7.309   -15.259 -23.184 0.35 60.36  ? 367  LYS A CE  1 
ATOM   656  N  NZ  . LYS A 1 104 ? 7.426   -14.525 -21.902 0.35 61.95  ? 367  LYS A NZ  1 
ATOM   657  N  N   . GLU A 1 105 ? 3.304   -12.491 -27.444 1.00 52.64  ? 368  GLU A N   1 
ATOM   658  C  CA  . GLU A 1 105 ? 2.432   -11.834 -28.442 1.00 55.36  ? 368  GLU A CA  1 
ATOM   659  C  C   . GLU A 1 105 ? 2.254   -12.759 -29.647 1.00 49.08  ? 368  GLU A C   1 
ATOM   660  O  O   . GLU A 1 105 ? 1.117   -12.826 -30.155 1.00 52.72  ? 368  GLU A O   1 
ATOM   661  C  CB  . GLU A 1 105 ? 3.026   -10.460 -28.789 1.00 68.03  ? 368  GLU A CB  1 
ATOM   662  C  CG  . GLU A 1 105 ? 3.170   -9.534  -27.579 1.00 66.85  ? 368  GLU A CG  1 
ATOM   663  C  CD  . GLU A 1 105 ? 1.907   -9.364  -26.749 1.00 70.34  ? 368  GLU A CD  1 
ATOM   664  O  OE1 . GLU A 1 105 ? 0.879   -8.960  -27.320 1.00 72.96  ? 368  GLU A OE1 1 
ATOM   665  O  OE2 . GLU A 1 105 ? 1.941   -9.665  -25.539 1.00 74.56  ? 368  GLU A OE2 1 
ATOM   666  N  N   . GLY A 1 106 ? 3.302   -13.486 -30.054 1.00 48.61  ? 369  GLY A N   1 
ATOM   667  C  CA  . GLY A 1 106 ? 3.231   -14.420 -31.202 1.00 46.89  ? 369  GLY A CA  1 
ATOM   668  C  C   . GLY A 1 106 ? 2.304   -15.606 -30.893 1.00 46.81  ? 369  GLY A C   1 
ATOM   669  O  O   . GLY A 1 106 ? 1.528   -15.979 -31.775 1.00 47.84  ? 369  GLY A O   1 
ATOM   670  N  N   . THR A 1 107 ? 2.381   -16.179 -29.690 1.00 42.04  ? 370  THR A N   1 
ATOM   671  C  CA  . THR A 1 107 ? 1.434   -17.210 -29.193 1.00 47.75  ? 370  THR A CA  1 
ATOM   672  C  C   . THR A 1 107 ? -0.011  -16.685 -29.314 1.00 51.59  ? 370  THR A C   1 
ATOM   673  O  O   . THR A 1 107 ? -0.804  -17.269 -30.122 1.00 44.00  ? 370  THR A O   1 
ATOM   674  C  CB  . THR A 1 107 ? 1.810   -17.632 -27.767 1.00 43.41  ? 370  THR A CB  1 
ATOM   675  O  OG1 . THR A 1 107 ? 3.221   -17.855 -27.718 1.00 40.16  ? 370  THR A OG1 1 
ATOM   676  C  CG2 . THR A 1 107 ? 1.094   -18.896 -27.345 1.00 43.10  ? 370  THR A CG2 1 
ATOM   677  N  N   . LYS A 1 108 ? -0.342  -15.593 -28.601 1.00 52.71  ? 371  LYS A N   1 
ATOM   678  C  CA  . LYS A 1 108 ? -1.678  -14.904 -28.624 1.00 47.88  ? 371  LYS A CA  1 
ATOM   679  C  C   . LYS A 1 108 ? -2.226  -14.700 -30.056 1.00 43.58  ? 371  LYS A C   1 
ATOM   680  O  O   . LYS A 1 108 ? -3.440  -14.919 -30.281 1.00 41.46  ? 371  LYS A O   1 
ATOM   681  C  CB  . LYS A 1 108 ? -1.607  -13.609 -27.808 1.00 49.80  ? 371  LYS A CB  1 
ATOM   682  C  CG  . LYS A 1 108 ? -1.435  -13.837 -26.314 1.00 52.99  ? 371  LYS A CG  1 
ATOM   683  C  CD  . LYS A 1 108 ? -1.690  -12.620 -25.455 1.00 55.92  ? 371  LYS A CD  1 
ATOM   684  C  CE  . LYS A 1 108 ? -0.573  -11.610 -25.546 1.00 63.57  ? 371  LYS A CE  1 
ATOM   685  N  NZ  . LYS A 1 108 ? -0.623  -10.650 -24.419 1.00 72.60  ? 371  LYS A NZ  1 
ATOM   686  N  N   . LYS A 1 109 ? -1.343  -14.345 -30.996 0.35 42.38  ? 372  LYS A N   1 
ATOM   687  C  CA  . LYS A 1 109 ? -1.659  -14.119 -32.433 0.35 42.73  ? 372  LYS A CA  1 
ATOM   688  C  C   . LYS A 1 109 ? -2.012  -15.447 -33.118 0.35 42.60  ? 372  LYS A C   1 
ATOM   689  O  O   . LYS A 1 109 ? -2.973  -15.456 -33.924 0.35 42.67  ? 372  LYS A O   1 
ATOM   690  C  CB  . LYS A 1 109 ? -0.468  -13.459 -33.135 0.35 45.87  ? 372  LYS A CB  1 
ATOM   691  C  CG  . LYS A 1 109 ? -0.775  -12.809 -34.479 0.35 49.13  ? 372  LYS A CG  1 
ATOM   692  C  CD  . LYS A 1 109 ? -1.802  -11.685 -34.412 0.35 51.17  ? 372  LYS A CD  1 
ATOM   693  C  CE  . LYS A 1 109 ? -1.506  -10.648 -33.345 0.35 52.37  ? 372  LYS A CE  1 
ATOM   694  N  NZ  . LYS A 1 109 ? -2.407  -9.474  -33.455 0.35 53.49  ? 372  LYS A NZ  1 
ATOM   695  N  N   . LEU A 1 110 ? -1.242  -16.511 -32.843 0.35 40.78  ? 373  LEU A N   1 
ATOM   696  C  CA  . LEU A 1 110 ? -1.478  -17.889 -33.364 0.35 38.82  ? 373  LEU A CA  1 
ATOM   697  C  C   . LEU A 1 110 ? -2.837  -18.393 -32.859 0.35 36.23  ? 373  LEU A C   1 
ATOM   698  O  O   . LEU A 1 110 ? -3.598  -18.953 -33.674 0.35 35.19  ? 373  LEU A O   1 
ATOM   699  C  CB  . LEU A 1 110 ? -0.347  -18.823 -32.912 0.35 39.09  ? 373  LEU A CB  1 
ATOM   700  C  CG  . LEU A 1 110 ? 1.017   -18.591 -33.563 0.35 39.38  ? 373  LEU A CG  1 
ATOM   701  C  CD1 . LEU A 1 110 ? 2.128   -19.257 -32.760 0.35 37.86  ? 373  LEU A CD1 1 
ATOM   702  C  CD2 . LEU A 1 110 ? 1.024   -19.087 -35.001 0.35 39.23  ? 373  LEU A CD2 1 
ATOM   703  N  N   . MET A 1 111 ? -3.120  -18.189 -31.568 1.00 33.51  ? 374  MET A N   1 
ATOM   704  C  CA  . MET A 1 111 ? -4.367  -18.658 -30.908 1.00 37.25  ? 374  MET A CA  1 
ATOM   705  C  C   . MET A 1 111 ? -5.621  -17.955 -31.478 1.00 42.69  ? 374  MET A C   1 
ATOM   706  O  O   . MET A 1 111 ? -6.634  -18.667 -31.764 1.00 38.14  ? 374  MET A O   1 
ATOM   707  C  CB  . MET A 1 111 ? -4.283  -18.488 -29.384 1.00 34.13  ? 374  MET A CB  1 
ATOM   708  C  CG  . MET A 1 111 ? -3.293  -19.477 -28.738 1.00 34.35  ? 374  MET A CG  1 
ATOM   709  S  SD  . MET A 1 111 ? -3.425  -19.661 -26.924 1.00 40.34  ? 374  MET A SD  1 
ATOM   710  C  CE  . MET A 1 111 ? -3.135  -17.986 -26.375 1.00 43.83  ? 374  MET A CE  1 
ATOM   711  N  N   . LYS A 1 112 ? -5.556  -16.628 -31.656 0.35 41.20  ? 375  LYS A N   1 
ATOM   712  C  CA  . LYS A 1 112 ? -6.683  -15.779 -32.141 0.35 43.47  ? 375  LYS A CA  1 
ATOM   713  C  C   . LYS A 1 112 ? -6.998  -16.141 -33.600 0.35 41.97  ? 375  LYS A C   1 
ATOM   714  O  O   . LYS A 1 112 ? -8.185  -16.332 -33.909 0.35 40.69  ? 375  LYS A O   1 
ATOM   715  C  CB  . LYS A 1 112 ? -6.352  -14.284 -32.020 0.35 47.43  ? 375  LYS A CB  1 
ATOM   716  C  CG  . LYS A 1 112 ? -7.530  -13.358 -31.723 0.35 49.87  ? 375  LYS A CG  1 
ATOM   717  C  CD  . LYS A 1 112 ? -7.606  -12.916 -30.264 0.35 52.67  ? 375  LYS A CD  1 
ATOM   718  C  CE  . LYS A 1 112 ? -8.902  -12.223 -29.890 0.35 53.44  ? 375  LYS A CE  1 
ATOM   719  N  NZ  . LYS A 1 112 ? -9.039  -12.069 -28.419 0.35 53.95  ? 375  LYS A NZ  1 
ATOM   720  N  N   . ILE A 1 113 ? -5.974  -16.227 -34.457 1.00 39.87  ? 376  ILE A N   1 
ATOM   721  C  CA  . ILE A 1 113 ? -6.148  -16.588 -35.898 1.00 42.83  ? 376  ILE A CA  1 
ATOM   722  C  C   . ILE A 1 113 ? -6.743  -17.993 -36.033 1.00 42.86  ? 376  ILE A C   1 
ATOM   723  O  O   . ILE A 1 113 ? -7.674  -18.181 -36.877 1.00 39.79  ? 376  ILE A O   1 
ATOM   724  C  CB  . ILE A 1 113 ? -4.829  -16.506 -36.681 1.00 42.26  ? 376  ILE A CB  1 
ATOM   725  C  CG1 . ILE A 1 113 ? -4.337  -15.065 -36.813 1.00 53.30  ? 376  ILE A CG1 1 
ATOM   726  C  CG2 . ILE A 1 113 ? -4.964  -17.149 -38.049 1.00 41.19  ? 376  ILE A CG2 1 
ATOM   727  C  CD1 . ILE A 1 113 ? -2.888  -14.953 -37.245 1.00 56.06  ? 376  ILE A CD1 1 
ATOM   728  N  N   . THR A 1 114 ? -6.213  -18.959 -35.267 1.00 44.47  ? 377  THR A N   1 
ATOM   729  C  CA  . THR A 1 114 ? -6.665  -20.381 -35.309 1.00 37.53  ? 377  THR A CA  1 
ATOM   730  C  C   . THR A 1 114 ? -8.097  -20.473 -34.799 1.00 32.67  ? 377  THR A C   1 
ATOM   731  O  O   . THR A 1 114 ? -8.918  -21.193 -35.471 1.00 31.68  ? 377  THR A O   1 
ATOM   732  C  CB  . THR A 1 114 ? -5.727  -21.321 -34.539 1.00 36.20  ? 377  THR A CB  1 
ATOM   733  O  OG1 . THR A 1 114 ? -4.424  -21.126 -35.064 1.00 34.05  ? 377  THR A OG1 1 
ATOM   734  C  CG2 . THR A 1 114 ? -6.053  -22.777 -34.741 1.00 36.74  ? 377  THR A CG2 1 
ATOM   735  N  N   . ALA A 1 115 ? -8.393  -19.787 -33.682 1.00 33.66  ? 378  ALA A N   1 
ATOM   736  C  CA  . ALA A 1 115 ? -9.727  -19.803 -33.040 1.00 35.00  ? 378  ALA A CA  1 
ATOM   737  C  C   . ALA A 1 115 ? -10.793 -19.198 -33.977 1.00 37.76  ? 378  ALA A C   1 
ATOM   738  O  O   . ALA A 1 115 ? -11.913 -19.788 -34.129 1.00 39.17  ? 378  ALA A O   1 
ATOM   739  C  CB  . ALA A 1 115 ? -9.707  -19.115 -31.712 1.00 33.01  ? 378  ALA A CB  1 
ATOM   740  N  N   . GLU A 1 116 ? -10.466 -18.070 -34.612 0.35 37.44  ? 379  GLU A N   1 
ATOM   741  C  CA  . GLU A 1 116 ? -11.365 -17.376 -35.575 0.35 38.22  ? 379  GLU A CA  1 
ATOM   742  C  C   . GLU A 1 116 ? -11.704 -18.357 -36.708 0.35 37.56  ? 379  GLU A C   1 
ATOM   743  O  O   . GLU A 1 116 ? -12.903 -18.543 -36.980 0.35 39.52  ? 379  GLU A O   1 
ATOM   744  C  CB  . GLU A 1 116 ? -10.721 -16.072 -36.060 0.35 37.91  ? 379  GLU A CB  1 
ATOM   745  C  CG  . GLU A 1 116 ? -11.716 -15.053 -36.595 0.35 39.41  ? 379  GLU A CG  1 
ATOM   746  C  CD  . GLU A 1 116 ? -11.345 -13.588 -36.403 0.35 39.70  ? 379  GLU A CD  1 
ATOM   747  O  OE1 . GLU A 1 116 ? -10.241 -13.313 -35.882 0.35 39.34  ? 379  GLU A OE1 1 
ATOM   748  O  OE2 . GLU A 1 116 ? -12.172 -12.721 -36.769 0.35 41.54  ? 379  GLU A OE2 1 
ATOM   749  N  N   . TRP A 1 117 ? -10.691 -18.984 -37.313 1.00 36.72  ? 380  TRP A N   1 
ATOM   750  C  CA  . TRP A 1 117 ? -10.876 -19.975 -38.402 1.00 33.20  ? 380  TRP A CA  1 
ATOM   751  C  C   . TRP A 1 117 ? -11.651 -21.224 -37.891 1.00 39.83  ? 380  TRP A C   1 
ATOM   752  O  O   . TRP A 1 117 ? -12.529 -21.775 -38.633 1.00 37.25  ? 380  TRP A O   1 
ATOM   753  C  CB  . TRP A 1 117 ? -9.495  -20.347 -38.942 1.00 33.29  ? 380  TRP A CB  1 
ATOM   754  C  CG  . TRP A 1 117 ? -9.546  -21.451 -39.938 1.00 30.18  ? 380  TRP A CG  1 
ATOM   755  C  CD1 . TRP A 1 117 ? -9.685  -21.312 -41.277 1.00 33.32  ? 380  TRP A CD1 1 
ATOM   756  C  CD2 . TRP A 1 117 ? -9.524  -22.864 -39.681 1.00 34.82  ? 380  TRP A CD2 1 
ATOM   757  N  NE1 . TRP A 1 117 ? -9.647  -22.532 -41.890 1.00 36.16  ? 380  TRP A NE1 1 
ATOM   758  C  CE2 . TRP A 1 117 ? -9.594  -23.511 -40.932 1.00 34.68  ? 380  TRP A CE2 1 
ATOM   759  C  CE3 . TRP A 1 117 ? -9.364  -23.651 -38.537 1.00 32.98  ? 380  TRP A CE3 1 
ATOM   760  C  CZ2 . TRP A 1 117 ? -9.562  -24.900 -41.061 1.00 35.49  ? 380  TRP A CZ2 1 
ATOM   761  C  CZ3 . TRP A 1 117 ? -9.308  -25.017 -38.668 1.00 32.17  ? 380  TRP A CZ3 1 
ATOM   762  C  CH2 . TRP A 1 117 ? -9.439  -25.635 -39.908 1.00 32.85  ? 380  TRP A CH2 1 
ATOM   763  N  N   . LEU A 1 118 ? -11.383 -21.694 -36.670 1.00 35.57  ? 381  LEU A N   1 
ATOM   764  C  CA  . LEU A 1 118 ? -12.008 -22.970 -36.195 1.00 33.26  ? 381  LEU A CA  1 
ATOM   765  C  C   . LEU A 1 118 ? -13.516 -22.761 -35.964 1.00 32.12  ? 381  LEU A C   1 
ATOM   766  O  O   . LEU A 1 118 ? -14.279 -23.616 -36.491 1.00 29.16  ? 381  LEU A O   1 
ATOM   767  C  CB  . LEU A 1 118 ? -11.310 -23.500 -34.942 1.00 31.30  ? 381  LEU A CB  1 
ATOM   768  C  CG  . LEU A 1 118 ? -11.745 -24.909 -34.512 1.00 34.98  ? 381  LEU A CG  1 
ATOM   769  C  CD1 . LEU A 1 118 ? -11.549 -25.928 -35.644 1.00 30.58  ? 381  LEU A CD1 1 
ATOM   770  C  CD2 . LEU A 1 118 ? -10.998 -25.323 -33.246 1.00 33.36  ? 381  LEU A CD2 1 
ATOM   771  N  N   . TRP A 1 119 ? -13.940 -21.700 -35.238 1.00 30.20  ? 382  TRP A N   1 
ATOM   772  C  CA  . TRP A 1 119 ? -15.387 -21.364 -35.068 1.00 35.60  ? 382  TRP A CA  1 
ATOM   773  C  C   . TRP A 1 119 ? -16.074 -21.210 -36.446 1.00 36.73  ? 382  TRP A C   1 
ATOM   774  O  O   . TRP A 1 119 ? -17.198 -21.799 -36.660 1.00 40.52  ? 382  TRP A O   1 
ATOM   775  C  CB  . TRP A 1 119 ? -15.596 -20.107 -34.242 1.00 31.81  ? 382  TRP A CB  1 
ATOM   776  C  CG  . TRP A 1 119 ? -15.354 -20.259 -32.780 1.00 31.22  ? 382  TRP A CG  1 
ATOM   777  C  CD1 . TRP A 1 119 ? -14.562 -19.477 -32.003 1.00 31.79  ? 382  TRP A CD1 1 
ATOM   778  C  CD2 . TRP A 1 119 ? -15.955 -21.228 -31.904 1.00 30.91  ? 382  TRP A CD2 1 
ATOM   779  N  NE1 . TRP A 1 119 ? -14.644 -19.865 -30.695 1.00 32.90  ? 382  TRP A NE1 1 
ATOM   780  C  CE2 . TRP A 1 119 ? -15.493 -20.938 -30.605 1.00 33.57  ? 382  TRP A CE2 1 
ATOM   781  C  CE3 . TRP A 1 119 ? -16.911 -22.237 -32.072 1.00 31.17  ? 382  TRP A CE3 1 
ATOM   782  C  CZ2 . TRP A 1 119 ? -15.893 -21.688 -29.503 1.00 33.48  ? 382  TRP A CZ2 1 
ATOM   783  C  CZ3 . TRP A 1 119 ? -17.312 -22.979 -30.984 1.00 29.93  ? 382  TRP A CZ3 1 
ATOM   784  C  CH2 . TRP A 1 119 ? -16.778 -22.727 -29.726 1.00 33.58  ? 382  TRP A CH2 1 
ATOM   785  N  N   . LYS A 1 120 ? -15.430 -20.556 -37.409 1.00 33.84  ? 383  LYS A N   1 
ATOM   786  C  CA  . LYS A 1 120 ? -16.045 -20.497 -38.761 1.00 39.15  ? 383  LYS A CA  1 
ATOM   787  C  C   . LYS A 1 120 ? -16.213 -21.916 -39.285 1.00 35.42  ? 383  LYS A C   1 
ATOM   788  O  O   . LYS A 1 120 ? -17.313 -22.222 -39.784 1.00 40.02  ? 383  LYS A O   1 
ATOM   789  C  CB  . LYS A 1 120 ? -15.283 -19.613 -39.755 1.00 48.14  ? 383  LYS A CB  1 
ATOM   790  C  CG  . LYS A 1 120 ? -15.392 -18.130 -39.443 1.00 57.38  ? 383  LYS A CG  1 
ATOM   791  C  CD  . LYS A 1 120 ? -14.820 -17.207 -40.482 1.00 65.98  ? 383  LYS A CD  1 
ATOM   792  C  CE  . LYS A 1 120 ? -14.578 -15.826 -39.911 1.00 67.68  ? 383  LYS A CE  1 
ATOM   793  N  NZ  . LYS A 1 120 ? -13.260 -15.309 -40.352 1.00 79.19  ? 383  LYS A NZ  1 
ATOM   794  N  N   . GLU A 1 121 ? -15.193 -22.774 -39.218 1.00 36.22  ? 384  GLU A N   1 
ATOM   795  C  CA  . GLU A 1 121 ? -15.343 -24.148 -39.779 1.00 35.40  ? 384  GLU A CA  1 
ATOM   796  C  C   . GLU A 1 121 ? -16.465 -24.876 -39.052 1.00 33.70  ? 384  GLU A C   1 
ATOM   797  O  O   . GLU A 1 121 ? -17.232 -25.595 -39.722 1.00 36.37  ? 384  GLU A O   1 
ATOM   798  C  CB  . GLU A 1 121 ? -14.116 -25.031 -39.622 1.00 39.51  ? 384  GLU A CB  1 
ATOM   799  C  CG  . GLU A 1 121 ? -13.009 -24.608 -40.523 1.00 42.93  ? 384  GLU A CG  1 
ATOM   800  C  CD  . GLU A 1 121 ? -13.293 -24.715 -42.003 1.00 47.04  ? 384  GLU A CD  1 
ATOM   801  O  OE1 . GLU A 1 121 ? -13.736 -25.799 -42.482 1.00 44.33  ? 384  GLU A OE1 1 
ATOM   802  O  OE2 . GLU A 1 121 ? -13.021 -23.707 -42.660 1.00 52.02  ? 384  GLU A OE2 1 
ATOM   803  N  N   . LEU A 1 122 ? -16.541 -24.755 -37.724 1.00 33.39  ? 385  LEU A N   1 
ATOM   804  C  CA  . LEU A 1 122 ? -17.522 -25.564 -36.949 1.00 32.04  ? 385  LEU A CA  1 
ATOM   805  C  C   . LEU A 1 122 ? -18.926 -25.043 -37.298 1.00 37.12  ? 385  LEU A C   1 
ATOM   806  O  O   . LEU A 1 122 ? -19.897 -25.836 -37.274 1.00 35.77  ? 385  LEU A O   1 
ATOM   807  C  CB  . LEU A 1 122 ? -17.219 -25.446 -35.454 1.00 30.26  ? 385  LEU A CB  1 
ATOM   808  C  CG  . LEU A 1 122 ? -15.952 -26.178 -35.008 1.00 31.91  ? 385  LEU A CG  1 
ATOM   809  C  CD1 . LEU A 1 122 ? -15.667 -25.949 -33.538 1.00 32.17  ? 385  LEU A CD1 1 
ATOM   810  C  CD2 . LEU A 1 122 ? -16.088 -27.665 -35.291 1.00 34.16  ? 385  LEU A CD2 1 
ATOM   811  N  N   . GLY A 1 123 ? -18.996 -23.758 -37.652 1.00 38.22  ? 386  GLY A N   1 
ATOM   812  C  CA  . GLY A 1 123 ? -20.227 -23.015 -37.966 1.00 39.40  ? 386  GLY A CA  1 
ATOM   813  C  C   . GLY A 1 123 ? -20.710 -23.221 -39.381 1.00 40.34  ? 386  GLY A C   1 
ATOM   814  O  O   . GLY A 1 123 ? -21.882 -22.907 -39.613 1.00 41.69  ? 386  GLY A O   1 
ATOM   815  N  N   . LYS A 1 124 ? -19.899 -23.742 -40.300 1.00 38.80  ? 387  LYS A N   1 
ATOM   816  C  CA  . LYS A 1 124 ? -20.308 -23.796 -41.734 1.00 43.36  ? 387  LYS A CA  1 
ATOM   817  C  C   . LYS A 1 124 ? -21.615 -24.567 -41.938 1.00 45.53  ? 387  LYS A C   1 
ATOM   818  O  O   . LYS A 1 124 ? -22.376 -24.140 -42.786 1.00 51.66  ? 387  LYS A O   1 
ATOM   819  C  CB  . LYS A 1 124 ? -19.244 -24.398 -42.646 1.00 41.83  ? 387  LYS A CB  1 
ATOM   820  C  CG  . LYS A 1 124 ? -18.118 -23.436 -43.014 1.00 49.09  ? 387  LYS A CG  1 
ATOM   821  C  CD  . LYS A 1 124 ? -17.120 -24.044 -43.993 1.00 52.15  ? 387  LYS A CD  1 
ATOM   822  C  CE  . LYS A 1 124 ? -15.797 -23.316 -44.084 1.00 52.51  ? 387  LYS A CE  1 
ATOM   823  N  NZ  . LYS A 1 124 ? -14.888 -24.073 -44.978 1.00 62.30  ? 387  LYS A NZ  1 
ATOM   824  N  N   . LYS A 1 125 ? -21.855 -25.672 -41.233 1.00 45.43  ? 388  LYS A N   1 
ATOM   825  C  CA  . LYS A 1 125 ? -23.051 -26.535 -41.433 1.00 42.64  ? 388  LYS A CA  1 
ATOM   826  C  C   . LYS A 1 125 ? -23.904 -26.606 -40.149 1.00 39.03  ? 388  LYS A C   1 
ATOM   827  O  O   . LYS A 1 125 ? -24.670 -27.543 -39.990 1.00 42.21  ? 388  LYS A O   1 
ATOM   828  C  CB  . LYS A 1 125 ? -22.600 -27.923 -41.874 1.00 47.02  ? 388  LYS A CB  1 
ATOM   829  C  CG  . LYS A 1 125 ? -21.802 -27.980 -43.163 1.00 53.30  ? 388  LYS A CG  1 
ATOM   830  C  CD  . LYS A 1 125 ? -21.416 -29.420 -43.522 1.00 61.33  ? 388  LYS A CD  1 
ATOM   831  C  CE  . LYS A 1 125 ? -20.220 -29.938 -42.738 1.00 72.64  ? 388  LYS A CE  1 
ATOM   832  N  NZ  . LYS A 1 125 ? -20.437 -31.310 -42.207 1.00 73.10  ? 388  LYS A NZ  1 
ATOM   833  N  N   . LYS A 1 126 ? -23.802 -25.642 -39.244 1.00 39.04  ? 389  LYS A N   1 
ATOM   834  C  CA  . LYS A 1 126 ? -24.579 -25.665 -37.983 1.00 42.35  ? 389  LYS A CA  1 
ATOM   835  C  C   . LYS A 1 126 ? -25.094 -24.257 -37.744 1.00 44.80  ? 389  LYS A C   1 
ATOM   836  O  O   . LYS A 1 126 ? -24.401 -23.330 -38.156 1.00 48.42  ? 389  LYS A O   1 
ATOM   837  C  CB  . LYS A 1 126 ? -23.713 -26.035 -36.775 1.00 42.04  ? 389  LYS A CB  1 
ATOM   838  C  CG  . LYS A 1 126 ? -23.102 -27.422 -36.843 1.00 39.28  ? 389  LYS A CG  1 
ATOM   839  C  CD  . LYS A 1 126 ? -24.080 -28.446 -36.377 1.00 39.93  ? 389  LYS A CD  1 
ATOM   840  C  CE  . LYS A 1 126 ? -23.501 -29.827 -36.367 1.00 39.86  ? 389  LYS A CE  1 
ATOM   841  N  NZ  . LYS A 1 126 ? -24.584 -30.806 -36.409 1.00 38.06  ? 389  LYS A NZ  1 
ATOM   842  N  N   . THR A 1 127 ? -26.223 -24.132 -37.032 1.00 44.21  ? 390  THR A N   1 
ATOM   843  C  CA  . THR A 1 127 ? -26.846 -22.832 -36.697 1.00 43.15  ? 390  THR A CA  1 
ATOM   844  C  C   . THR A 1 127 ? -26.899 -22.634 -35.195 1.00 30.57  ? 390  THR A C   1 
ATOM   845  O  O   . THR A 1 127 ? -27.729 -23.210 -34.519 1.00 39.72  ? 390  THR A O   1 
ATOM   846  C  CB  . THR A 1 127 ? -28.275 -22.729 -37.254 1.00 47.12  ? 390  THR A CB  1 
ATOM   847  O  OG1 . THR A 1 127 ? -28.102 -22.713 -38.671 1.00 41.74  ? 390  THR A OG1 1 
ATOM   848  C  CG2 . THR A 1 127 ? -28.994 -21.497 -36.737 1.00 45.15  ? 390  THR A CG2 1 
ATOM   849  N  N   . PRO A 1 128 ? -26.120 -21.716 -34.623 1.00 32.28  ? 391  PRO A N   1 
ATOM   850  C  CA  . PRO A 1 128 ? -26.267 -21.462 -33.191 1.00 35.76  ? 391  PRO A CA  1 
ATOM   851  C  C   . PRO A 1 128 ? -27.740 -21.135 -32.856 1.00 41.34  ? 391  PRO A C   1 
ATOM   852  O  O   . PRO A 1 128 ? -28.440 -20.498 -33.650 1.00 43.60  ? 391  PRO A O   1 
ATOM   853  C  CB  . PRO A 1 128 ? -25.338 -20.283 -32.913 1.00 31.78  ? 391  PRO A CB  1 
ATOM   854  C  CG  . PRO A 1 128 ? -24.435 -20.193 -34.120 1.00 30.96  ? 391  PRO A CG  1 
ATOM   855  C  CD  . PRO A 1 128 ? -25.151 -20.836 -35.286 1.00 30.54  ? 391  PRO A CD  1 
ATOM   856  N  N   . ARG A 1 129 ? -28.210 -21.575 -31.702 1.00 42.27  ? 392  ARG A N   1 
ATOM   857  C  CA  . ARG A 1 129 ? -29.610 -21.309 -31.290 1.00 40.86  ? 392  ARG A CA  1 
ATOM   858  C  C   . ARG A 1 129 ? -29.727 -21.481 -29.782 1.00 48.40  ? 392  ARG A C   1 
ATOM   859  O  O   . ARG A 1 129 ? -28.852 -22.143 -29.178 1.00 40.78  ? 392  ARG A O   1 
ATOM   860  C  CB  . ARG A 1 129 ? -30.585 -22.197 -32.068 1.00 40.70  ? 392  ARG A CB  1 
ATOM   861  C  CG  . ARG A 1 129 ? -30.318 -23.693 -32.037 1.00 41.71  ? 392  ARG A CG  1 
ATOM   862  C  CD  . ARG A 1 129 ? -31.116 -24.347 -30.951 1.00 41.71  ? 392  ARG A CD  1 
ATOM   863  N  NE  . ARG A 1 129 ? -30.865 -25.762 -30.779 1.00 38.30  ? 392  ARG A NE  1 
ATOM   864  C  CZ  . ARG A 1 129 ? -31.410 -26.487 -29.821 1.00 38.60  ? 392  ARG A CZ  1 
ATOM   865  N  NH1 . ARG A 1 129 ? -32.284 -25.930 -29.001 1.00 36.25  ? 392  ARG A NH1 1 
ATOM   866  N  NH2 . ARG A 1 129 ? -31.152 -27.779 -29.731 1.00 35.25  ? 392  ARG A NH2 1 
ATOM   867  N  N   . MET A 1 130 ? -30.775 -20.889 -29.206 1.00 46.78  ? 393  MET A N   1 
ATOM   868  C  CA  . MET A 1 130 ? -31.058 -20.955 -27.760 1.00 44.05  ? 393  MET A CA  1 
ATOM   869  C  C   . MET A 1 130 ? -31.678 -22.307 -27.449 1.00 41.35  ? 393  MET A C   1 
ATOM   870  O  O   . MET A 1 130 ? -32.429 -22.864 -28.290 1.00 42.93  ? 393  MET A O   1 
ATOM   871  C  CB  . MET A 1 130 ? -32.009 -19.838 -27.335 1.00 55.55  ? 393  MET A CB  1 
ATOM   872  C  CG  . MET A 1 130 ? -31.295 -18.558 -26.971 1.00 64.08  ? 393  MET A CG  1 
ATOM   873  S  SD  . MET A 1 130 ? -32.419 -17.327 -26.258 1.00 73.97  ? 393  MET A SD  1 
ATOM   874  C  CE  . MET A 1 130 ? -32.879 -16.440 -27.744 1.00 75.34  ? 393  MET A CE  1 
ATOM   875  N  N   . CYS A 1 131 ? -31.313 -22.864 -26.308 1.00 38.17  ? 394  CYS A N   1 
ATOM   876  C  CA  . CYS A 1 131 ? -31.990 -24.056 -25.755 1.00 38.11  ? 394  CYS A CA  1 
ATOM   877  C  C   . CYS A 1 131 ? -33.130 -23.561 -24.830 1.00 41.42  ? 394  CYS A C   1 
ATOM   878  O  O   . CYS A 1 131 ? -33.077 -22.386 -24.356 1.00 46.59  ? 394  CYS A O   1 
ATOM   879  C  CB  . CYS A 1 131 ? -30.970 -24.977 -25.086 1.00 40.75  ? 394  CYS A CB  1 
ATOM   880  S  SG  . CYS A 1 131 ? -29.854 -25.812 -26.255 1.00 43.16  ? 394  CYS A SG  1 
ATOM   881  N  N   . THR A 1 132 ? -34.172 -24.366 -24.636 1.00 44.59  ? 395  THR A N   1 
ATOM   882  C  CA  . THR A 1 132 ? -35.474 -23.908 -24.078 1.00 51.01  ? 395  THR A CA  1 
ATOM   883  C  C   . THR A 1 132 ? -35.720 -24.523 -22.698 1.00 51.99  ? 395  THR A C   1 
ATOM   884  O  O   . THR A 1 132 ? -35.150 -25.618 -22.414 1.00 48.53  ? 395  THR A O   1 
ATOM   885  C  CB  . THR A 1 132 ? -36.604 -24.271 -25.044 1.00 49.26  ? 395  THR A CB  1 
ATOM   886  O  OG1 . THR A 1 132 ? -36.617 -25.696 -25.154 1.00 49.31  ? 395  THR A OG1 1 
ATOM   887  C  CG2 . THR A 1 132 ? -36.423 -23.627 -26.402 1.00 52.39  ? 395  THR A CG2 1 
ATOM   888  N  N   . ARG A 1 133 ? -36.563 -23.856 -21.902 1.00 56.20  ? 396  ARG A N   1 
ATOM   889  C  CA  . ARG A 1 133 ? -37.120 -24.385 -20.623 1.00 59.34  ? 396  ARG A CA  1 
ATOM   890  C  C   . ARG A 1 133 ? -37.679 -25.780 -20.895 1.00 57.53  ? 396  ARG A C   1 
ATOM   891  O  O   . ARG A 1 133 ? -37.402 -26.712 -20.117 1.00 62.42  ? 396  ARG A O   1 
ATOM   892  C  CB  . ARG A 1 133 ? -38.223 -23.484 -20.051 1.00 67.13  ? 396  ARG A CB  1 
ATOM   893  C  CG  . ARG A 1 133 ? -37.909 -21.998 -20.132 1.00 77.56  ? 396  ARG A CG  1 
ATOM   894  C  CD  . ARG A 1 133 ? -38.593 -21.105 -19.108 1.00 88.45  ? 396  ARG A CD  1 
ATOM   895  N  NE  . ARG A 1 133 ? -37.858 -19.850 -18.955 1.00 87.98  ? 396  ARG A NE  1 
ATOM   896  C  CZ  . ARG A 1 133 ? -38.148 -18.891 -18.079 1.00 92.44  ? 396  ARG A CZ  1 
ATOM   897  N  NH1 . ARG A 1 133 ? -39.186 -19.013 -17.269 1.00 91.87  ? 396  ARG A NH1 1 
ATOM   898  N  NH2 . ARG A 1 133 ? -37.401 -17.801 -18.030 1.00 84.53  ? 396  ARG A NH2 1 
ATOM   899  N  N   . GLU A 1 134 ? -38.424 -25.924 -21.988 1.00 60.22  ? 397  GLU A N   1 
ATOM   900  C  CA  . GLU A 1 134 ? -39.015 -27.221 -22.375 1.00 61.37  ? 397  GLU A CA  1 
ATOM   901  C  C   . GLU A 1 134 ? -37.863 -28.218 -22.341 1.00 56.65  ? 397  GLU A C   1 
ATOM   902  O  O   . GLU A 1 134 ? -37.870 -29.035 -21.445 1.00 63.52  ? 397  GLU A O   1 
ATOM   903  C  CB  . GLU A 1 134 ? -39.728 -27.116 -23.724 1.00 74.06  ? 397  GLU A CB  1 
ATOM   904  C  CG  . GLU A 1 134 ? -41.047 -26.353 -23.673 1.00 85.34  ? 397  GLU A CG  1 
ATOM   905  C  CD  . GLU A 1 134 ? -41.015 -24.868 -23.302 1.00 91.32  ? 397  GLU A CD  1 
ATOM   906  O  OE1 . GLU A 1 134 ? -40.017 -24.168 -23.628 1.00 83.08  ? 397  GLU A OE1 1 
ATOM   907  O  OE2 . GLU A 1 134 ? -42.009 -24.397 -22.691 1.00 89.66  ? 397  GLU A OE2 1 
ATOM   908  N  N   . GLU A 1 135 ? -36.846 -28.053 -23.204 1.00 66.45  ? 398  GLU A N   1 
ATOM   909  C  CA  . GLU A 1 135 ? -35.672 -28.973 -23.313 1.00 61.24  ? 398  GLU A CA  1 
ATOM   910  C  C   . GLU A 1 135 ? -35.031 -29.188 -21.935 1.00 60.59  ? 398  GLU A C   1 
ATOM   911  O  O   . GLU A 1 135 ? -34.692 -30.346 -21.612 1.00 60.71  ? 398  GLU A O   1 
ATOM   912  C  CB  . GLU A 1 135 ? -34.569 -28.422 -24.221 1.00 57.91  ? 398  GLU A CB  1 
ATOM   913  C  CG  . GLU A 1 135 ? -34.915 -28.441 -25.680 1.00 56.03  ? 398  GLU A CG  1 
ATOM   914  C  CD  . GLU A 1 135 ? -33.860 -27.775 -26.540 1.00 53.95  ? 398  GLU A CD  1 
ATOM   915  O  OE1 . GLU A 1 135 ? -33.657 -26.559 -26.388 1.00 51.98  ? 398  GLU A OE1 1 
ATOM   916  O  OE2 . GLU A 1 135 ? -33.252 -28.476 -27.361 1.00 57.64  ? 398  GLU A OE2 1 
ATOM   917  N  N   . PHE A 1 136 ? -34.811 -28.105 -21.182 1.00 60.47  ? 399  PHE A N   1 
ATOM   918  C  CA  . PHE A 1 136 ? -34.124 -28.153 -19.867 1.00 60.13  ? 399  PHE A CA  1 
ATOM   919  C  C   . PHE A 1 136 ? -34.956 -29.029 -18.907 1.00 71.56  ? 399  PHE A C   1 
ATOM   920  O  O   . PHE A 1 136 ? -34.413 -29.935 -18.214 1.00 61.25  ? 399  PHE A O   1 
ATOM   921  C  CB  . PHE A 1 136 ? -33.873 -26.738 -19.339 1.00 59.52  ? 399  PHE A CB  1 
ATOM   922  C  CG  . PHE A 1 136 ? -33.147 -26.759 -18.019 1.00 65.07  ? 399  PHE A CG  1 
ATOM   923  C  CD1 . PHE A 1 136 ? -31.793 -27.032 -17.975 1.00 58.12  ? 399  PHE A CD1 1 
ATOM   924  C  CD2 . PHE A 1 136 ? -33.833 -26.612 -16.823 1.00 64.49  ? 399  PHE A CD2 1 
ATOM   925  C  CE1 . PHE A 1 136 ? -31.122 -27.093 -16.770 1.00 57.56  ? 399  PHE A CE1 1 
ATOM   926  C  CE2 . PHE A 1 136 ? -33.164 -26.676 -15.615 1.00 63.40  ? 399  PHE A CE2 1 
ATOM   927  C  CZ  . PHE A 1 136 ? -31.806 -26.912 -15.592 1.00 65.80  ? 399  PHE A CZ  1 
ATOM   928  N  N   . THR A 1 137 ? -36.270 -28.792 -18.888 1.00 71.60  ? 400  THR A N   1 
ATOM   929  C  CA  . THR A 1 137 ? -37.256 -29.561 -18.081 1.00 74.78  ? 400  THR A CA  1 
ATOM   930  C  C   . THR A 1 137 ? -37.192 -31.058 -18.419 1.00 75.01  ? 400  THR A C   1 
ATOM   931  O  O   . THR A 1 137 ? -37.070 -31.872 -17.512 1.00 64.42  ? 400  THR A O   1 
ATOM   932  C  CB  . THR A 1 137 ? -38.664 -28.983 -18.265 1.00 71.82  ? 400  THR A CB  1 
ATOM   933  O  OG1 . THR A 1 137 ? -38.605 -27.645 -17.769 1.00 78.36  ? 400  THR A OG1 1 
ATOM   934  C  CG2 . THR A 1 137 ? -39.741 -29.790 -17.576 1.00 68.74  ? 400  THR A CG2 1 
ATOM   935  N  N   . ARG A 1 138 ? -37.241 -31.400 -19.709 0.35 76.06  ? 401  ARG A N   1 
ATOM   936  C  CA  . ARG A 1 138 ? -37.303 -32.808 -20.188 0.35 79.54  ? 401  ARG A CA  1 
ATOM   937  C  C   . ARG A 1 138 ? -35.991 -33.537 -19.857 0.35 80.80  ? 401  ARG A C   1 
ATOM   938  O  O   . ARG A 1 138 ? -36.026 -34.779 -19.772 0.35 82.85  ? 401  ARG A O   1 
ATOM   939  C  CB  . ARG A 1 138 ? -37.611 -32.848 -21.688 0.35 82.59  ? 401  ARG A CB  1 
ATOM   940  C  CG  . ARG A 1 138 ? -38.142 -34.188 -22.181 0.35 84.45  ? 401  ARG A CG  1 
ATOM   941  C  CD  . ARG A 1 138 ? -38.914 -34.052 -23.481 0.35 84.99  ? 401  ARG A CD  1 
ATOM   942  N  NE  . ARG A 1 138 ? -38.178 -33.264 -24.464 0.35 86.63  ? 401  ARG A NE  1 
ATOM   943  C  CZ  . ARG A 1 138 ? -37.289 -33.742 -25.336 0.35 86.36  ? 401  ARG A CZ  1 
ATOM   944  N  NH1 . ARG A 1 138 ? -37.005 -35.034 -25.381 0.35 85.52  ? 401  ARG A NH1 1 
ATOM   945  N  NH2 . ARG A 1 138 ? -36.683 -32.913 -26.170 0.35 86.84  ? 401  ARG A NH2 1 
ATOM   946  N  N   . LYS A 1 139 ? -34.885 -32.806 -19.675 0.35 81.69  ? 402  LYS A N   1 
ATOM   947  C  CA  . LYS A 1 139 ? -33.558 -33.379 -19.313 0.35 83.06  ? 402  LYS A CA  1 
ATOM   948  C  C   . LYS A 1 139 ? -33.571 -33.835 -17.847 0.35 86.03  ? 402  LYS A C   1 
ATOM   949  O  O   . LYS A 1 139 ? -33.131 -34.974 -17.587 0.35 86.73  ? 402  LYS A O   1 
ATOM   950  C  CB  . LYS A 1 139 ? -32.426 -32.374 -19.558 0.35 82.92  ? 402  LYS A CB  1 
ATOM   951  C  CG  . LYS A 1 139 ? -31.984 -32.237 -21.009 0.35 82.76  ? 402  LYS A CG  1 
ATOM   952  C  CD  . LYS A 1 139 ? -30.818 -31.288 -21.206 0.35 82.22  ? 402  LYS A CD  1 
ATOM   953  C  CE  . LYS A 1 139 ? -29.477 -31.897 -20.852 0.35 81.59  ? 402  LYS A CE  1 
ATOM   954  N  NZ  . LYS A 1 139 ? -29.059 -32.922 -21.839 0.35 80.58  ? 402  LYS A NZ  1 
ATOM   955  N  N   . VAL A 1 140 ? -34.056 -32.989 -16.930 0.35 87.34  ? 403  VAL A N   1 
ATOM   956  C  CA  . VAL A 1 140 ? -34.042 -33.258 -15.458 0.35 88.98  ? 403  VAL A CA  1 
ATOM   957  C  C   . VAL A 1 140 ? -35.027 -34.393 -15.142 0.35 91.29  ? 403  VAL A C   1 
ATOM   958  O  O   . VAL A 1 140 ? -34.808 -35.092 -14.131 0.35 92.12  ? 403  VAL A O   1 
ATOM   959  C  CB  . VAL A 1 140 ? -34.338 -31.996 -14.619 0.35 88.05  ? 403  VAL A CB  1 
ATOM   960  C  CG1 . VAL A 1 140 ? -33.432 -30.834 -14.999 0.35 87.72  ? 403  VAL A CG1 1 
ATOM   961  C  CG2 . VAL A 1 140 ? -35.797 -31.569 -14.680 0.35 88.54  ? 403  VAL A CG2 1 
ATOM   962  N  N   . ARG A 1 141 ? -36.054 -34.580 -15.981 0.35 91.64  ? 404  ARG A N   1 
ATOM   963  C  CA  . ARG A 1 141 ? -37.149 -35.567 -15.766 0.35 92.36  ? 404  ARG A CA  1 
ATOM   964  C  C   . ARG A 1 141 ? -36.762 -36.943 -16.329 0.35 94.99  ? 404  ARG A C   1 
ATOM   965  O  O   . ARG A 1 141 ? -37.659 -37.804 -16.418 0.35 97.58  ? 404  ARG A O   1 
ATOM   966  C  CB  . ARG A 1 141 ? -38.454 -35.047 -16.380 0.35 89.75  ? 404  ARG A CB  1 
ATOM   967  C  CG  . ARG A 1 141 ? -39.079 -33.897 -15.602 0.35 89.07  ? 404  ARG A CG  1 
ATOM   968  C  CD  . ARG A 1 141 ? -40.552 -34.115 -15.305 0.35 89.95  ? 404  ARG A CD  1 
ATOM   969  N  NE  . ARG A 1 141 ? -41.428 -33.635 -16.367 0.35 88.96  ? 404  ARG A NE  1 
ATOM   970  C  CZ  . ARG A 1 141 ? -41.944 -32.409 -16.447 0.35 86.68  ? 404  ARG A CZ  1 
ATOM   971  N  NH1 . ARG A 1 141 ? -41.675 -31.496 -15.525 0.35 85.76  ? 404  ARG A NH1 1 
ATOM   972  N  NH2 . ARG A 1 141 ? -42.734 -32.097 -17.460 0.35 86.74  ? 404  ARG A NH2 1 
ATOM   973  N  N   . SER A 1 142 ? -35.487 -37.151 -16.683 0.35 98.53  ? 405  SER A N   1 
ATOM   974  C  CA  . SER A 1 142 ? -34.912 -38.477 -17.042 0.35 101.71 ? 405  SER A CA  1 
ATOM   975  C  C   . SER A 1 142 ? -33.447 -38.572 -16.588 0.35 104.52 ? 405  SER A C   1 
ATOM   976  O  O   . SER A 1 142 ? -32.655 -39.240 -17.286 0.35 102.99 ? 405  SER A O   1 
ATOM   977  C  CB  . SER A 1 142 ? -35.065 -38.749 -18.520 0.35 101.51 ? 405  SER A CB  1 
ATOM   978  O  OG  . SER A 1 142 ? -34.450 -37.730 -19.292 0.35 103.49 ? 405  SER A OG  1 
ATOM   979  N  N   . ASN A 1 143 ? -33.115 -37.941 -15.452 0.35 108.26 ? 406  ASN A N   1 
ATOM   980  C  CA  . ASN A 1 143 ? -31.796 -38.014 -14.762 0.35 111.11 ? 406  ASN A CA  1 
ATOM   981  C  C   . ASN A 1 143 ? -30.707 -37.345 -15.612 0.35 114.02 ? 406  ASN A C   1 
ATOM   982  O  O   . ASN A 1 143 ? -30.247 -37.969 -16.589 0.35 117.34 ? 406  ASN A O   1 
ATOM   983  C  CB  . ASN A 1 143 ? -31.413 -39.455 -14.412 0.35 110.00 ? 406  ASN A CB  1 
ATOM   984  C  CG  . ASN A 1 143 ? -32.435 -40.136 -13.528 0.35 109.76 ? 406  ASN A CG  1 
ATOM   985  O  OD1 . ASN A 1 143 ? -32.933 -41.210 -13.859 0.35 111.89 ? 406  ASN A OD1 1 
ATOM   986  N  ND2 . ASN A 1 143 ? -32.760 -39.517 -12.405 0.35 108.96 ? 406  ASN A ND2 1 
ATOM   987  N  N   . ALA A 1 144 ? -30.308 -36.125 -15.235 0.35 118.00 ? 407  ALA A N   1 
ATOM   988  C  CA  . ALA A 1 144 ? -29.172 -35.372 -15.821 0.35 118.79 ? 407  ALA A CA  1 
ATOM   989  C  C   . ALA A 1 144 ? -28.714 -34.277 -14.844 0.35 117.58 ? 407  ALA A C   1 
ATOM   990  O  O   . ALA A 1 144 ? -28.558 -33.115 -15.278 0.35 118.56 ? 407  ALA A O   1 
ATOM   991  C  CB  . ALA A 1 144 ? -29.567 -34.804 -17.164 0.35 118.78 ? 407  ALA A CB  1 
ATOM   992  N  N   . ALA A 1 145 ? -28.508 -34.645 -13.573 0.35 114.83 ? 408  ALA A N   1 
ATOM   993  C  CA  . ALA A 1 145 ? -27.980 -33.777 -12.493 0.35 110.49 ? 408  ALA A CA  1 
ATOM   994  C  C   . ALA A 1 145 ? -26.456 -33.938 -12.426 0.35 106.80 ? 408  ALA A C   1 
ATOM   995  O  O   . ALA A 1 145 ? -25.994 -35.080 -12.228 0.35 109.66 ? 408  ALA A O   1 
ATOM   996  C  CB  . ALA A 1 145 ? -28.634 -34.129 -11.178 0.35 109.36 ? 408  ALA A CB  1 
ATOM   997  N  N   . LEU A 1 146 ? -25.712 -32.837 -12.584 0.35 99.67  ? 409  LEU A N   1 
ATOM   998  C  CA  . LEU A 1 146 ? -24.232 -32.838 -12.754 0.35 93.95  ? 409  LEU A CA  1 
ATOM   999  C  C   . LEU A 1 146 ? -23.619 -31.634 -12.024 0.35 90.00  ? 409  LEU A C   1 
ATOM   1000 O  O   . LEU A 1 146 ? -23.124 -30.707 -12.694 0.35 89.81  ? 409  LEU A O   1 
ATOM   1001 C  CB  . LEU A 1 146 ? -23.905 -32.845 -14.253 0.35 93.50  ? 409  LEU A CB  1 
ATOM   1002 C  CG  . LEU A 1 146 ? -24.908 -32.155 -15.181 0.35 94.44  ? 409  LEU A CG  1 
ATOM   1003 C  CD1 . LEU A 1 146 ? -24.884 -30.642 -15.012 0.35 95.22  ? 409  LEU A CD1 1 
ATOM   1004 C  CD2 . LEU A 1 146 ? -24.640 -32.525 -16.631 0.35 93.96  ? 409  LEU A CD2 1 
ATOM   1005 N  N   . GLY A 1 147 ? -23.633 -31.674 -10.688 0.35 85.56  ? 410  GLY A N   1 
ATOM   1006 C  CA  . GLY A 1 147 ? -23.150 -30.589 -9.812  0.35 81.98  ? 410  GLY A CA  1 
ATOM   1007 C  C   . GLY A 1 147 ? -24.158 -29.456 -9.730  0.35 78.79  ? 410  GLY A C   1 
ATOM   1008 O  O   . GLY A 1 147 ? -24.004 -28.480 -10.492 0.35 71.87  ? 410  GLY A O   1 
ATOM   1009 N  N   . ALA A 1 148 ? -25.153 -29.583 -8.842  0.35 76.65  ? 411  ALA A N   1 
ATOM   1010 C  CA  . ALA A 1 148 ? -26.285 -28.639 -8.681  0.35 78.37  ? 411  ALA A CA  1 
ATOM   1011 C  C   . ALA A 1 148 ? -26.530 -28.332 -7.196  0.35 77.90  ? 411  ALA A C   1 
ATOM   1012 O  O   . ALA A 1 148 ? -26.057 -29.104 -6.338  0.35 80.24  ? 411  ALA A O   1 
ATOM   1013 C  CB  . ALA A 1 148 ? -27.521 -29.212 -9.332  0.35 77.91  ? 411  ALA A CB  1 
ATOM   1014 N  N   . ILE A 1 149 ? -27.235 -27.226 -6.925  0.35 77.09  ? 412  ILE A N   1 
ATOM   1015 C  CA  . ILE A 1 149 ? -27.759 -26.826 -5.582  0.35 76.44  ? 412  ILE A CA  1 
ATOM   1016 C  C   . ILE A 1 149 ? -29.208 -26.353 -5.764  0.35 76.29  ? 412  ILE A C   1 
ATOM   1017 O  O   . ILE A 1 149 ? -29.904 -26.954 -6.609  0.35 73.96  ? 412  ILE A O   1 
ATOM   1018 C  CB  . ILE A 1 149 ? -26.864 -25.764 -4.894  0.35 76.55  ? 412  ILE A CB  1 
ATOM   1019 C  CG1 . ILE A 1 149 ? -27.684 -24.629 -4.264  0.35 77.53  ? 412  ILE A CG1 1 
ATOM   1020 C  CG2 . ILE A 1 149 ? -25.805 -25.222 -5.844  0.35 76.60  ? 412  ILE A CG2 1 
ATOM   1021 C  CD1 . ILE A 1 149 ? -26.866 -23.617 -3.489  0.35 77.77  ? 412  ILE A CD1 1 
ATOM   1022 N  N   . TRP A 1 156 ? -37.005 -25.915 -2.430  0.35 77.08  ? 419  TRP A N   1 
ATOM   1023 C  CA  . TRP A 1 156 ? -37.292 -27.275 -2.963  0.35 78.50  ? 419  TRP A CA  1 
ATOM   1024 C  C   . TRP A 1 156 ? -36.242 -28.271 -2.458  0.35 79.87  ? 419  TRP A C   1 
ATOM   1025 O  O   . TRP A 1 156 ? -35.186 -27.828 -1.959  0.35 79.43  ? 419  TRP A O   1 
ATOM   1026 C  CB  . TRP A 1 156 ? -37.337 -27.269 -4.497  0.35 78.27  ? 419  TRP A CB  1 
ATOM   1027 C  CG  . TRP A 1 156 ? -38.191 -26.191 -5.088  0.35 78.14  ? 419  TRP A CG  1 
ATOM   1028 C  CD1 . TRP A 1 156 ? -39.494 -26.294 -5.480  0.35 77.87  ? 419  TRP A CD1 1 
ATOM   1029 C  CD2 . TRP A 1 156 ? -37.795 -24.834 -5.363  0.35 77.16  ? 419  TRP A CD2 1 
ATOM   1030 N  NE1 . TRP A 1 156 ? -39.936 -25.099 -5.979  0.35 77.79  ? 419  TRP A NE1 1 
ATOM   1031 C  CE2 . TRP A 1 156 ? -38.917 -24.184 -5.920  0.35 76.58  ? 419  TRP A CE2 1 
ATOM   1032 C  CE3 . TRP A 1 156 ? -36.609 -24.109 -5.194  0.35 77.24  ? 419  TRP A CE3 1 
ATOM   1033 C  CZ2 . TRP A 1 156 ? -38.882 -22.844 -6.305  0.35 76.66  ? 419  TRP A CZ2 1 
ATOM   1034 C  CZ3 . TRP A 1 156 ? -36.575 -22.786 -5.576  0.35 76.11  ? 419  TRP A CZ3 1 
ATOM   1035 C  CH2 . TRP A 1 156 ? -37.698 -22.165 -6.123  0.35 77.45  ? 419  TRP A CH2 1 
ATOM   1036 N  N   . LYS A 1 157 ? -36.529 -29.568 -2.608  0.35 80.39  ? 420  LYS A N   1 
ATOM   1037 C  CA  . LYS A 1 157 ? -35.626 -30.692 -2.240  0.35 78.86  ? 420  LYS A CA  1 
ATOM   1038 C  C   . LYS A 1 157 ? -34.709 -30.998 -3.430  0.35 77.72  ? 420  LYS A C   1 
ATOM   1039 O  O   . LYS A 1 157 ? -33.479 -30.865 -3.273  0.35 78.14  ? 420  LYS A O   1 
ATOM   1040 C  CB  . LYS A 1 157 ? -36.456 -31.919 -1.847  0.35 80.21  ? 420  LYS A CB  1 
ATOM   1041 C  CG  . LYS A 1 157 ? -35.668 -33.184 -1.526  0.35 80.81  ? 420  LYS A CG  1 
ATOM   1042 C  CD  . LYS A 1 157 ? -36.437 -34.457 -1.830  0.35 81.51  ? 420  LYS A CD  1 
ATOM   1043 C  CE  . LYS A 1 157 ? -37.729 -34.582 -1.047  0.35 79.75  ? 420  LYS A CE  1 
ATOM   1044 N  NZ  . LYS A 1 157 ? -38.719 -35.425 -1.757  0.35 79.18  ? 420  LYS A NZ  1 
ATOM   1045 N  N   . SER A 1 158 ? -35.298 -31.386 -4.567  0.35 73.80  ? 421  SER A N   1 
ATOM   1046 C  CA  . SER A 1 158 ? -34.595 -31.811 -5.807  0.35 71.12  ? 421  SER A CA  1 
ATOM   1047 C  C   . SER A 1 158 ? -34.829 -30.793 -6.929  0.35 72.62  ? 421  SER A C   1 
ATOM   1048 O  O   . SER A 1 158 ? -35.655 -29.872 -6.747  0.35 70.65  ? 421  SER A O   1 
ATOM   1049 C  CB  . SER A 1 158 ? -35.033 -33.191 -6.228  0.35 68.71  ? 421  SER A CB  1 
ATOM   1050 O  OG  . SER A 1 158 ? -36.442 -33.248 -6.390  0.35 66.31  ? 421  SER A OG  1 
ATOM   1051 N  N   . ALA A 1 159 ? -34.115 -30.968 -8.045  0.35 73.66  ? 422  ALA A N   1 
ATOM   1052 C  CA  . ALA A 1 159 ? -34.237 -30.165 -9.284  0.35 74.30  ? 422  ALA A CA  1 
ATOM   1053 C  C   . ALA A 1 159 ? -35.481 -30.606 -10.066 0.35 73.87  ? 422  ALA A C   1 
ATOM   1054 O  O   . ALA A 1 159 ? -35.999 -29.794 -10.855 0.35 71.57  ? 422  ALA A O   1 
ATOM   1055 C  CB  . ALA A 1 159 ? -32.985 -30.312 -10.114 0.35 75.72  ? 422  ALA A CB  1 
ATOM   1056 N  N   . ARG A 1 160 ? -35.933 -31.848 -9.855  0.35 75.65  ? 423  ARG A N   1 
ATOM   1057 C  CA  . ARG A 1 160 ? -37.163 -32.416 -10.471 0.35 76.99  ? 423  ARG A CA  1 
ATOM   1058 C  C   . ARG A 1 160 ? -38.382 -31.604 -10.007 0.35 78.42  ? 423  ARG A C   1 
ATOM   1059 O  O   . ARG A 1 160 ? -39.287 -31.380 -10.836 0.35 78.03  ? 423  ARG A O   1 
ATOM   1060 C  CB  . ARG A 1 160 ? -37.295 -33.902 -10.117 0.35 78.16  ? 423  ARG A CB  1 
ATOM   1061 C  CG  . ARG A 1 160 ? -38.136 -34.707 -11.099 0.35 80.44  ? 423  ARG A CG  1 
ATOM   1062 C  CD  . ARG A 1 160 ? -38.211 -36.180 -10.737 0.35 80.47  ? 423  ARG A CD  1 
ATOM   1063 N  NE  . ARG A 1 160 ? -37.143 -36.973 -11.343 0.35 80.81  ? 423  ARG A NE  1 
ATOM   1064 C  CZ  . ARG A 1 160 ? -37.309 -37.957 -12.231 0.35 81.68  ? 423  ARG A CZ  1 
ATOM   1065 N  NH1 . ARG A 1 160 ? -36.252 -38.597 -12.703 0.35 82.12  ? 423  ARG A NH1 1 
ATOM   1066 N  NH2 . ARG A 1 160 ? -38.516 -38.308 -12.646 0.35 81.45  ? 423  ARG A NH2 1 
ATOM   1067 N  N   . GLU A 1 161 ? -38.394 -31.170 -8.739  0.35 78.51  ? 424  GLU A N   1 
ATOM   1068 C  CA  . GLU A 1 161 ? -39.492 -30.373 -8.121  0.35 78.55  ? 424  GLU A CA  1 
ATOM   1069 C  C   . GLU A 1 161 ? -39.442 -28.927 -8.626  0.35 75.53  ? 424  GLU A C   1 
ATOM   1070 O  O   . GLU A 1 161 ? -40.475 -28.444 -9.131  0.35 73.58  ? 424  GLU A O   1 
ATOM   1071 C  CB  . GLU A 1 161 ? -39.382 -30.377 -6.594  0.35 81.63  ? 424  GLU A CB  1 
ATOM   1072 C  CG  . GLU A 1 161 ? -39.728 -31.711 -5.958  0.35 84.53  ? 424  GLU A CG  1 
ATOM   1073 C  CD  . GLU A 1 161 ? -39.815 -31.672 -4.441  0.35 86.41  ? 424  GLU A CD  1 
ATOM   1074 O  OE1 . GLU A 1 161 ? -39.044 -30.906 -3.823  0.35 85.41  ? 424  GLU A OE1 1 
ATOM   1075 O  OE2 . GLU A 1 161 ? -40.661 -32.401 -3.883  0.35 86.68  ? 424  GLU A OE2 1 
ATOM   1076 N  N   . ALA A 1 162 ? -38.282 -28.275 -8.483  0.35 74.67  ? 425  ALA A N   1 
ATOM   1077 C  CA  . ALA A 1 162 ? -38.044 -26.837 -8.764  0.35 75.28  ? 425  ALA A CA  1 
ATOM   1078 C  C   . ALA A 1 162 ? -38.538 -26.462 -10.169 0.35 75.80  ? 425  ALA A C   1 
ATOM   1079 O  O   . ALA A 1 162 ? -39.021 -25.325 -10.340 0.35 74.23  ? 425  ALA A O   1 
ATOM   1080 C  CB  . ALA A 1 162 ? -36.576 -26.522 -8.605  0.35 74.31  ? 425  ALA A CB  1 
ATOM   1081 N  N   . VAL A 1 163 ? -38.411 -27.384 -11.128 0.35 77.66  ? 426  VAL A N   1 
ATOM   1082 C  CA  . VAL A 1 163 ? -38.749 -27.177 -12.569 0.35 81.03  ? 426  VAL A CA  1 
ATOM   1083 C  C   . VAL A 1 163 ? -40.275 -27.179 -12.755 0.35 83.92  ? 426  VAL A C   1 
ATOM   1084 O  O   . VAL A 1 163 ? -40.739 -26.627 -13.770 0.35 84.20  ? 426  VAL A O   1 
ATOM   1085 C  CB  . VAL A 1 163 ? -38.045 -28.236 -13.444 0.35 82.25  ? 426  VAL A CB  1 
ATOM   1086 C  CG1 . VAL A 1 163 ? -38.690 -28.390 -14.812 0.35 82.26  ? 426  VAL A CG1 1 
ATOM   1087 C  CG2 . VAL A 1 163 ? -36.559 -27.936 -13.588 0.35 81.00  ? 426  VAL A CG2 1 
ATOM   1088 N  N   . GLU A 1 164 ? -41.029 -27.762 -11.817 0.35 90.13  ? 427  GLU A N   1 
ATOM   1089 C  CA  . GLU A 1 164 ? -42.518 -27.804 -11.843 0.35 93.70  ? 427  GLU A CA  1 
ATOM   1090 C  C   . GLU A 1 164 ? -43.073 -26.767 -10.855 0.35 95.89  ? 427  GLU A C   1 
ATOM   1091 O  O   . GLU A 1 164 ? -43.961 -27.126 -10.057 0.35 102.49 ? 427  GLU A O   1 
ATOM   1092 C  CB  . GLU A 1 164 ? -43.002 -29.222 -11.528 0.35 94.22  ? 427  GLU A CB  1 
ATOM   1093 C  CG  . GLU A 1 164 ? -42.693 -30.221 -12.629 0.35 96.03  ? 427  GLU A CG  1 
ATOM   1094 C  CD  . GLU A 1 164 ? -42.341 -31.619 -12.149 0.35 99.21  ? 427  GLU A CD  1 
ATOM   1095 O  OE1 . GLU A 1 164 ? -43.019 -32.122 -11.228 0.35 101.44 ? 427  GLU A OE1 1 
ATOM   1096 O  OE2 . GLU A 1 164 ? -41.381 -32.199 -12.692 0.35 98.89  ? 427  GLU A OE2 1 
ATOM   1097 N  N   . ASP A 1 165 ? -42.566 -25.530 -10.912 1.00 98.29  ? 428  ASP A N   1 
ATOM   1098 C  CA  . ASP A 1 165 ? -42.966 -24.437 -9.984  1.00 92.90  ? 428  ASP A CA  1 
ATOM   1099 C  C   . ASP A 1 165 ? -42.487 -23.104 -10.570 1.00 88.95  ? 428  ASP A C   1 
ATOM   1100 O  O   . ASP A 1 165 ? -41.260 -22.830 -10.514 1.00 84.02  ? 428  ASP A O   1 
ATOM   1101 C  CB  . ASP A 1 165 ? -42.386 -24.634 -8.580  1.00 93.64  ? 428  ASP A CB  1 
ATOM   1102 C  CG  . ASP A 1 165 ? -42.569 -23.422 -7.676  1.00 95.56  ? 428  ASP A CG  1 
ATOM   1103 O  OD1 . ASP A 1 165 ? -42.341 -22.287 -8.157  1.00 80.62  ? 428  ASP A OD1 1 
ATOM   1104 O  OD2 . ASP A 1 165 ? -42.946 -23.619 -6.497  1.00 111.76 ? 428  ASP A OD2 1 
ATOM   1105 N  N   . SER A 1 166 ? -43.423 -22.290 -11.062 1.00 87.39  ? 429  SER A N   1 
ATOM   1106 C  CA  . SER A 1 166 ? -43.168 -21.043 -11.831 1.00 78.13  ? 429  SER A CA  1 
ATOM   1107 C  C   . SER A 1 166 ? -42.429 -20.007 -10.976 1.00 76.22  ? 429  SER A C   1 
ATOM   1108 O  O   . SER A 1 166 ? -41.901 -19.050 -11.568 1.00 80.48  ? 429  SER A O   1 
ATOM   1109 C  CB  . SER A 1 166 ? -44.453 -20.485 -12.373 1.00 88.67  ? 429  SER A CB  1 
ATOM   1110 O  OG  . SER A 1 166 ? -45.289 -21.532 -12.850 1.00 93.59  ? 429  SER A OG  1 
ATOM   1111 N  N   . GLY A 1 167 ? -42.398 -20.173 -9.647  1.00 73.82  ? 430  GLY A N   1 
ATOM   1112 C  CA  . GLY A 1 167 ? -41.656 -19.285 -8.728  1.00 70.54  ? 430  GLY A CA  1 
ATOM   1113 C  C   . GLY A 1 167 ? -40.180 -19.280 -9.080  1.00 69.27  ? 430  GLY A C   1 
ATOM   1114 O  O   . GLY A 1 167 ? -39.643 -18.203 -9.324  1.00 68.58  ? 430  GLY A O   1 
ATOM   1115 N  N   . PHE A 1 168 ? -39.579 -20.469 -9.132  1.00 67.90  ? 431  PHE A N   1 
ATOM   1116 C  CA  . PHE A 1 168 ? -38.224 -20.751 -9.680  1.00 77.55  ? 431  PHE A CA  1 
ATOM   1117 C  C   . PHE A 1 168 ? -38.030 -19.974 -10.986 1.00 68.11  ? 431  PHE A C   1 
ATOM   1118 O  O   . PHE A 1 168 ? -37.105 -19.164 -11.086 1.00 74.99  ? 431  PHE A O   1 
ATOM   1119 C  CB  . PHE A 1 168 ? -38.035 -22.261 -9.896  1.00 88.32  ? 431  PHE A CB  1 
ATOM   1120 C  CG  . PHE A 1 168 ? -36.786 -22.661 -10.647 1.00 82.41  ? 431  PHE A CG  1 
ATOM   1121 C  CD1 . PHE A 1 168 ? -35.580 -22.820 -9.983  1.00 81.81  ? 431  PHE A CD1 1 
ATOM   1122 C  CD2 . PHE A 1 168 ? -36.817 -22.875 -12.017 1.00 80.59  ? 431  PHE A CD2 1 
ATOM   1123 C  CE1 . PHE A 1 168 ? -34.432 -23.180 -10.672 1.00 80.35  ? 431  PHE A CE1 1 
ATOM   1124 C  CE2 . PHE A 1 168 ? -35.668 -23.230 -12.705 1.00 81.67  ? 431  PHE A CE2 1 
ATOM   1125 C  CZ  . PHE A 1 168 ? -34.479 -23.388 -12.030 1.00 82.52  ? 431  PHE A CZ  1 
ATOM   1126 N  N   . TRP A 1 169 ? -38.917 -20.181 -11.956 1.00 70.17  ? 432  TRP A N   1 
ATOM   1127 C  CA  . TRP A 1 169 ? -38.816 -19.540 -13.293 1.00 68.14  ? 432  TRP A CA  1 
ATOM   1128 C  C   . TRP A 1 169 ? -38.868 -18.002 -13.176 1.00 73.85  ? 432  TRP A C   1 
ATOM   1129 O  O   . TRP A 1 169 ? -38.275 -17.329 -14.038 1.00 74.52  ? 432  TRP A O   1 
ATOM   1130 C  CB  . TRP A 1 169 ? -39.853 -20.143 -14.244 1.00 62.73  ? 432  TRP A CB  1 
ATOM   1131 C  CG  . TRP A 1 169 ? -39.536 -21.577 -14.534 1.00 70.05  ? 432  TRP A CG  1 
ATOM   1132 C  CD1 . TRP A 1 169 ? -40.202 -22.665 -14.062 1.00 73.58  ? 432  TRP A CD1 1 
ATOM   1133 C  CD2 . TRP A 1 169 ? -38.406 -22.095 -15.267 1.00 74.09  ? 432  TRP A CD2 1 
ATOM   1134 N  NE1 . TRP A 1 169 ? -39.588 -23.817 -14.472 1.00 71.10  ? 432  TRP A NE1 1 
ATOM   1135 C  CE2 . TRP A 1 169 ? -38.489 -23.502 -15.222 1.00 69.09  ? 432  TRP A CE2 1 
ATOM   1136 C  CE3 . TRP A 1 169 ? -37.342 -21.521 -15.972 1.00 79.37  ? 432  TRP A CE3 1 
ATOM   1137 C  CZ2 . TRP A 1 169 ? -37.561 -24.336 -15.851 1.00 71.24  ? 432  TRP A CZ2 1 
ATOM   1138 C  CZ3 . TRP A 1 169 ? -36.431 -22.347 -16.604 1.00 80.65  ? 432  TRP A CZ3 1 
ATOM   1139 C  CH2 . TRP A 1 169 ? -36.541 -23.736 -16.550 1.00 68.67  ? 432  TRP A CH2 1 
ATOM   1140 N  N   . GLU A 1 170 ? -39.468 -17.441 -12.123 1.00 78.14  ? 433  GLU A N   1 
ATOM   1141 C  CA  . GLU A 1 170 ? -39.472 -15.964 -11.911 1.00 83.11  ? 433  GLU A CA  1 
ATOM   1142 C  C   . GLU A 1 170 ? -38.073 -15.553 -11.434 1.00 72.22  ? 433  GLU A C   1 
ATOM   1143 O  O   . GLU A 1 170 ? -37.561 -14.523 -11.900 1.00 73.52  ? 433  GLU A O   1 
ATOM   1144 C  CB  . GLU A 1 170 ? -40.621 -15.546 -10.981 1.00 89.34  ? 433  GLU A CB  1 
ATOM   1145 C  CG  . GLU A 1 170 ? -41.987 -15.642 -11.657 1.00 99.44  ? 433  GLU A CG  1 
ATOM   1146 C  CD  . GLU A 1 170 ? -43.216 -15.677 -10.755 1.00 109.89 ? 433  GLU A CD  1 
ATOM   1147 O  OE1 . GLU A 1 170 ? -43.644 -14.595 -10.304 1.00 110.64 ? 433  GLU A OE1 1 
ATOM   1148 O  OE2 . GLU A 1 170 ? -43.762 -16.786 -10.525 1.00 109.04 ? 433  GLU A OE2 1 
ATOM   1149 N  N   . LEU A 1 171 ? -37.457 -16.349 -10.560 1.00 75.14  ? 434  LEU A N   1 
ATOM   1150 C  CA  . LEU A 1 171 ? -36.032 -16.167 -10.151 1.00 73.23  ? 434  LEU A CA  1 
ATOM   1151 C  C   . LEU A 1 171 ? -35.159 -16.118 -11.422 1.00 70.53  ? 434  LEU A C   1 
ATOM   1152 O  O   . LEU A 1 171 ? -34.346 -15.173 -11.587 1.00 64.02  ? 434  LEU A O   1 
ATOM   1153 C  CB  . LEU A 1 171 ? -35.602 -17.323 -9.239  1.00 68.15  ? 434  LEU A CB  1 
ATOM   1154 C  CG  . LEU A 1 171 ? -36.557 -17.717 -8.111  1.00 68.05  ? 434  LEU A CG  1 
ATOM   1155 C  CD1 . LEU A 1 171 ? -35.954 -18.828 -7.265  1.00 70.00  ? 434  LEU A CD1 1 
ATOM   1156 C  CD2 . LEU A 1 171 ? -36.917 -16.516 -7.248  1.00 68.87  ? 434  LEU A CD2 1 
ATOM   1157 N  N   . VAL A 1 172 ? -35.344 -17.114 -12.297 0.35 67.35  ? 435  VAL A N   1 
ATOM   1158 C  CA  . VAL A 1 172 ? -34.601 -17.285 -13.582 0.35 65.36  ? 435  VAL A CA  1 
ATOM   1159 C  C   . VAL A 1 172 ? -34.812 -16.037 -14.447 0.35 64.14  ? 435  VAL A C   1 
ATOM   1160 O  O   . VAL A 1 172 ? -33.821 -15.553 -15.023 0.35 61.89  ? 435  VAL A O   1 
ATOM   1161 C  CB  . VAL A 1 172 ? -35.034 -18.572 -14.314 0.35 66.46  ? 435  VAL A CB  1 
ATOM   1162 C  CG1 . VAL A 1 172 ? -34.450 -18.649 -15.718 0.35 67.31  ? 435  VAL A CG1 1 
ATOM   1163 C  CG2 . VAL A 1 172 ? -34.679 -19.823 -13.519 0.35 66.35  ? 435  VAL A CG2 1 
ATOM   1164 N  N   . ASP A 1 173 ? -36.050 -15.533 -14.521 0.35 65.71  ? 436  ASP A N   1 
ATOM   1165 C  CA  . ASP A 1 173 ? -36.408 -14.295 -15.267 0.35 64.46  ? 436  ASP A CA  1 
ATOM   1166 C  C   . ASP A 1 173 ? -35.639 -13.106 -14.676 0.35 63.14  ? 436  ASP A C   1 
ATOM   1167 O  O   . ASP A 1 173 ? -35.113 -12.293 -15.464 0.35 61.88  ? 436  ASP A O   1 
ATOM   1168 C  CB  . ASP A 1 173 ? -37.918 -14.029 -15.248 0.35 67.91  ? 436  ASP A CB  1 
ATOM   1169 C  CG  . ASP A 1 173 ? -38.752 -14.974 -16.101 0.35 70.62  ? 436  ASP A CG  1 
ATOM   1170 O  OD1 . ASP A 1 173 ? -38.195 -15.571 -17.047 0.35 69.80  ? 436  ASP A OD1 1 
ATOM   1171 O  OD2 . ASP A 1 173 ? -39.961 -15.105 -15.812 0.35 75.47  ? 436  ASP A OD2 1 
ATOM   1172 N  N   . LYS A 1 174 ? -35.570 -13.010 -13.344 0.35 63.40  ? 437  LYS A N   1 
ATOM   1173 C  CA  . LYS A 1 174 ? -34.898 -11.890 -12.628 0.35 64.36  ? 437  LYS A CA  1 
ATOM   1174 C  C   . LYS A 1 174 ? -33.411 -11.875 -13.007 0.35 64.00  ? 437  LYS A C   1 
ATOM   1175 O  O   . LYS A 1 174 ? -32.924 -10.803 -13.433 0.35 63.62  ? 437  LYS A O   1 
ATOM   1176 C  CB  . LYS A 1 174 ? -35.086 -12.013 -11.112 0.35 65.56  ? 437  LYS A CB  1 
ATOM   1177 C  CG  . LYS A 1 174 ? -34.659 -10.792 -10.307 0.35 67.33  ? 437  LYS A CG  1 
ATOM   1178 C  CD  . LYS A 1 174 ? -34.888 -10.938 -8.816  0.35 67.89  ? 437  LYS A CD  1 
ATOM   1179 C  CE  . LYS A 1 174 ? -34.344 -9.775  -8.014  0.35 68.40  ? 437  LYS A CE  1 
ATOM   1180 N  NZ  . LYS A 1 174 ? -34.658 -9.919  -6.573  0.35 69.29  ? 437  LYS A NZ  1 
ATOM   1181 N  N   . GLU A 1 175 ? -32.730 -13.020 -12.867 0.35 61.39  ? 438  GLU A N   1 
ATOM   1182 C  CA  . GLU A 1 175 ? -31.300 -13.205 -13.243 0.35 59.52  ? 438  GLU A CA  1 
ATOM   1183 C  C   . GLU A 1 175 ? -31.102 -12.866 -14.724 0.35 56.69  ? 438  GLU A C   1 
ATOM   1184 O  O   . GLU A 1 175 ? -30.137 -12.148 -15.046 0.35 56.62  ? 438  GLU A O   1 
ATOM   1185 C  CB  . GLU A 1 175 ? -30.848 -14.645 -12.990 0.35 61.03  ? 438  GLU A CB  1 
ATOM   1186 C  CG  . GLU A 1 175 ? -30.144 -14.844 -11.663 0.35 62.08  ? 438  GLU A CG  1 
ATOM   1187 C  CD  . GLU A 1 175 ? -28.772 -14.202 -11.584 0.35 59.64  ? 438  GLU A CD  1 
ATOM   1188 O  OE1 . GLU A 1 175 ? -27.776 -14.906 -11.848 0.35 62.21  ? 438  GLU A OE1 1 
ATOM   1189 O  OE2 . GLU A 1 175 ? -28.702 -13.006 -11.245 0.35 56.42  ? 438  GLU A OE2 1 
ATOM   1190 N  N   . ARG A 1 176 ? -31.988 -13.383 -15.579 0.35 56.14  ? 439  ARG A N   1 
ATOM   1191 C  CA  . ARG A 1 176 ? -31.921 -13.282 -17.062 0.35 57.74  ? 439  ARG A CA  1 
ATOM   1192 C  C   . ARG A 1 176 ? -31.930 -11.811 -17.495 0.35 58.48  ? 439  ARG A C   1 
ATOM   1193 O  O   . ARG A 1 176 ? -31.037 -11.420 -18.273 0.35 58.29  ? 439  ARG A O   1 
ATOM   1194 C  CB  . ARG A 1 176 ? -33.103 -14.049 -17.658 0.35 58.99  ? 439  ARG A CB  1 
ATOM   1195 C  CG  . ARG A 1 176 ? -33.078 -14.192 -19.170 0.35 60.01  ? 439  ARG A CG  1 
ATOM   1196 C  CD  . ARG A 1 176 ? -33.852 -15.441 -19.539 0.35 60.40  ? 439  ARG A CD  1 
ATOM   1197 N  NE  . ARG A 1 176 ? -34.259 -15.462 -20.932 0.35 63.97  ? 439  ARG A NE  1 
ATOM   1198 C  CZ  . ARG A 1 176 ? -34.928 -16.457 -21.504 0.35 68.56  ? 439  ARG A CZ  1 
ATOM   1199 N  NH1 . ARG A 1 176 ? -35.256 -17.531 -20.800 0.35 67.22  ? 439  ARG A NH1 1 
ATOM   1200 N  NH2 . ARG A 1 176 ? -35.255 -16.377 -22.784 0.35 69.76  ? 439  ARG A NH2 1 
ATOM   1201 N  N   . ASN A 1 177 ? -32.904 -11.033 -17.007 1.00 61.95  ? 440  ASN A N   1 
ATOM   1202 C  CA  . ASN A 1 177 ? -33.028 -9.578  -17.324 1.00 59.64  ? 440  ASN A CA  1 
ATOM   1203 C  C   . ASN A 1 177 ? -31.830 -8.842  -16.715 1.00 55.42  ? 440  ASN A C   1 
ATOM   1204 O  O   . ASN A 1 177 ? -31.310 -7.924  -17.375 1.00 60.52  ? 440  ASN A O   1 
ATOM   1205 C  CB  . ASN A 1 177 ? -34.382 -9.003  -16.886 1.00 68.29  ? 440  ASN A CB  1 
ATOM   1206 C  CG  . ASN A 1 177 ? -35.503 -9.408  -17.824 1.00 70.55  ? 440  ASN A CG  1 
ATOM   1207 O  OD1 . ASN A 1 177 ? -35.514 -9.029  -18.995 1.00 72.98  ? 440  ASN A OD1 1 
ATOM   1208 N  ND2 . ASN A 1 177 ? -36.438 -10.205 -17.337 1.00 71.57  ? 440  ASN A ND2 1 
ATOM   1209 N  N   . LEU A 1 178 ? -31.341 -9.273  -15.547 1.00 54.61  ? 441  LEU A N   1 
ATOM   1210 C  CA  . LEU A 1 178 ? -30.051 -8.754  -15.006 1.00 56.63  ? 441  LEU A CA  1 
ATOM   1211 C  C   . LEU A 1 178 ? -28.906 -9.019  -15.999 1.00 61.97  ? 441  LEU A C   1 
ATOM   1212 O  O   . LEU A 1 178 ? -28.129 -8.061  -16.258 1.00 65.12  ? 441  LEU A O   1 
ATOM   1213 C  CB  . LEU A 1 178 ? -29.762 -9.349  -13.625 1.00 58.90  ? 441  LEU A CB  1 
ATOM   1214 C  CG  . LEU A 1 178 ? -30.556 -8.739  -12.470 1.00 63.57  ? 441  LEU A CG  1 
ATOM   1215 C  CD1 . LEU A 1 178 ? -30.451 -9.608  -11.222 1.00 66.47  ? 441  LEU A CD1 1 
ATOM   1216 C  CD2 . LEU A 1 178 ? -30.081 -7.317  -12.185 1.00 66.16  ? 441  LEU A CD2 1 
ATOM   1217 N  N   . HIS A 1 179 ? -28.782 -10.230 -16.562 1.00 59.84  ? 442  HIS A N   1 
ATOM   1218 C  CA  . HIS A 1 179 ? -27.705 -10.530 -17.553 1.00 64.13  ? 442  HIS A CA  1 
ATOM   1219 C  C   . HIS A 1 179 ? -27.839 -9.578  -18.757 1.00 60.72  ? 442  HIS A C   1 
ATOM   1220 O  O   . HIS A 1 179 ? -26.827 -8.935  -19.083 1.00 63.60  ? 442  HIS A O   1 
ATOM   1221 C  CB  . HIS A 1 179 ? -27.656 -12.013 -17.981 1.00 58.77  ? 442  HIS A CB  1 
ATOM   1222 C  CG  . HIS A 1 179 ? -27.116 -12.960 -16.955 1.00 63.40  ? 442  HIS A CG  1 
ATOM   1223 N  ND1 . HIS A 1 179 ? -27.155 -14.337 -17.129 1.00 62.29  ? 442  HIS A ND1 1 
ATOM   1224 C  CD2 . HIS A 1 179 ? -26.556 -12.745 -15.741 1.00 60.58  ? 442  HIS A CD2 1 
ATOM   1225 C  CE1 . HIS A 1 179 ? -26.656 -14.912 -16.054 1.00 65.68  ? 442  HIS A CE1 1 
ATOM   1226 N  NE2 . HIS A 1 179 ? -26.269 -13.952 -15.191 1.00 57.20  ? 442  HIS A NE2 1 
ATOM   1227 N  N   . LEU A 1 180 ? -29.030 -9.451  -19.371 1.00 67.21  ? 443  LEU A N   1 
ATOM   1228 C  CA  . LEU A 1 180 ? -29.292 -8.523  -20.525 1.00 62.16  ? 443  LEU A CA  1 
ATOM   1229 C  C   . LEU A 1 180 ? -28.841 -7.097  -20.146 1.00 62.51  ? 443  LEU A C   1 
ATOM   1230 O  O   . LEU A 1 180 ? -28.449 -6.352  -21.036 1.00 61.43  ? 443  LEU A O   1 
ATOM   1231 C  CB  . LEU A 1 180 ? -30.775 -8.561  -20.918 1.00 61.61  ? 443  LEU A CB  1 
ATOM   1232 C  CG  . LEU A 1 180 ? -31.319 -9.892  -21.450 1.00 60.72  ? 443  LEU A CG  1 
ATOM   1233 C  CD1 . LEU A 1 180 ? -32.837 -9.886  -21.506 1.00 61.94  ? 443  LEU A CD1 1 
ATOM   1234 C  CD2 . LEU A 1 180 ? -30.775 -10.213 -22.831 1.00 65.50  ? 443  LEU A CD2 1 
ATOM   1235 N  N   . GLU A 1 181 ? -28.790 -6.784  -18.850 1.00 66.33  ? 444  GLU A N   1 
ATOM   1236 C  CA  . GLU A 1 181 ? -28.382 -5.472  -18.278 1.00 78.41  ? 444  GLU A CA  1 
ATOM   1237 C  C   . GLU A 1 181 ? -26.875 -5.452  -17.957 1.00 80.93  ? 444  GLU A C   1 
ATOM   1238 O  O   . GLU A 1 181 ? -26.423 -4.440  -17.378 1.00 82.90  ? 444  GLU A O   1 
ATOM   1239 C  CB  . GLU A 1 181 ? -29.210 -5.243  -17.009 1.00 84.40  ? 444  GLU A CB  1 
ATOM   1240 C  CG  . GLU A 1 181 ? -29.643 -3.815  -16.754 1.00 84.96  ? 444  GLU A CG  1 
ATOM   1241 C  CD  . GLU A 1 181 ? -30.239 -3.681  -15.362 1.00 89.36  ? 444  GLU A CD  1 
ATOM   1242 O  OE1 . GLU A 1 181 ? -29.711 -2.880  -14.567 1.00 84.74  ? 444  GLU A OE1 1 
ATOM   1243 O  OE2 . GLU A 1 181 ? -31.194 -4.429  -15.054 1.00 86.45  ? 444  GLU A OE2 1 
ATOM   1244 N  N   . GLY A 1 182 ? -26.131 -6.522  -18.286 1.00 74.78  ? 445  GLY A N   1 
ATOM   1245 C  CA  . GLY A 1 182 ? -24.674 -6.651  -18.051 1.00 60.50  ? 445  GLY A CA  1 
ATOM   1246 C  C   . GLY A 1 182 ? -24.293 -6.809  -16.581 1.00 56.29  ? 445  GLY A C   1 
ATOM   1247 O  O   . GLY A 1 182 ? -23.185 -6.419  -16.204 1.00 61.19  ? 445  GLY A O   1 
ATOM   1248 N  N   . LYS A 1 183 ? -25.195 -7.389  -15.783 0.35 56.55  ? 446  LYS A N   1 
ATOM   1249 C  CA  . LYS A 1 183 ? -25.064 -7.547  -14.308 0.35 57.92  ? 446  LYS A CA  1 
ATOM   1250 C  C   . LYS A 1 183 ? -25.403 -8.990  -13.916 0.35 54.72  ? 446  LYS A C   1 
ATOM   1251 O  O   . LYS A 1 183 ? -26.163 -9.636  -14.659 0.35 52.33  ? 446  LYS A O   1 
ATOM   1252 C  CB  . LYS A 1 183 ? -26.010 -6.581  -13.584 0.35 61.13  ? 446  LYS A CB  1 
ATOM   1253 C  CG  . LYS A 1 183 ? -25.679 -5.101  -13.737 0.35 63.16  ? 446  LYS A CG  1 
ATOM   1254 C  CD  . LYS A 1 183 ? -26.905 -4.222  -13.905 0.35 64.89  ? 446  LYS A CD  1 
ATOM   1255 C  CE  . LYS A 1 183 ? -26.648 -2.770  -13.559 0.35 66.70  ? 446  LYS A CE  1 
ATOM   1256 N  NZ  . LYS A 1 183 ? -26.755 -2.531  -12.100 0.35 67.04  ? 446  LYS A NZ  1 
ATOM   1257 N  N   . CYS A 1 184 ? -24.882 -9.455  -12.776 1.00 53.51  ? 447  CYS A N   1 
ATOM   1258 C  CA  . CYS A 1 184 ? -25.119 -10.823 -12.245 1.00 57.21  ? 447  CYS A CA  1 
ATOM   1259 C  C   . CYS A 1 184 ? -25.302 -10.726 -10.723 1.00 56.02  ? 447  CYS A C   1 
ATOM   1260 O  O   . CYS A 1 184 ? -24.630 -9.892  -10.096 1.00 62.12  ? 447  CYS A O   1 
ATOM   1261 C  CB  . CYS A 1 184 ? -23.929 -11.711 -12.627 1.00 57.90  ? 447  CYS A CB  1 
ATOM   1262 S  SG  . CYS A 1 184 ? -24.161 -13.453 -12.189 1.00 55.03  ? 447  CYS A SG  1 
ATOM   1263 N  N   . GLU A 1 185 ? -26.177 -11.570 -10.163 0.35 57.38  ? 448  GLU A N   1 
ATOM   1264 C  CA  . GLU A 1 185 ? -26.605 -11.515 -8.737  0.35 59.55  ? 448  GLU A CA  1 
ATOM   1265 C  C   . GLU A 1 185 ? -26.452 -12.884 -8.055  0.35 59.87  ? 448  GLU A C   1 
ATOM   1266 O  O   . GLU A 1 185 ? -26.011 -12.896 -6.884  0.35 60.03  ? 448  GLU A O   1 
ATOM   1267 C  CB  . GLU A 1 185 ? -28.050 -11.011 -8.659  0.35 61.72  ? 448  GLU A CB  1 
ATOM   1268 C  CG  . GLU A 1 185 ? -28.456 -10.507 -7.285  0.35 62.55  ? 448  GLU A CG  1 
ATOM   1269 C  CD  . GLU A 1 185 ? -29.818 -9.830  -7.245  0.35 64.41  ? 448  GLU A CD  1 
ATOM   1270 O  OE1 . GLU A 1 185 ? -29.901 -8.706  -6.708  0.35 64.69  ? 448  GLU A OE1 1 
ATOM   1271 O  OE2 . GLU A 1 185 ? -30.796 -10.427 -7.752  0.35 64.19  ? 448  GLU A OE2 1 
ATOM   1272 N  N   . THR A 1 186 ? -26.804 -13.988 -8.728  0.35 57.42  ? 449  THR A N   1 
ATOM   1273 C  CA  . THR A 1 186 ? -26.965 -15.327 -8.092  0.35 57.29  ? 449  THR A CA  1 
ATOM   1274 C  C   . THR A 1 186 ? -26.287 -16.436 -8.912  0.35 54.29  ? 449  THR A C   1 
ATOM   1275 O  O   . THR A 1 186 ? -26.799 -17.566 -8.873  0.35 53.17  ? 449  THR A O   1 
ATOM   1276 C  CB  . THR A 1 186 ? -28.450 -15.650 -7.862  0.35 58.63  ? 449  THR A CB  1 
ATOM   1277 O  OG1 . THR A 1 186 ? -29.033 -16.107 -9.084  0.35 59.71  ? 449  THR A OG1 1 
ATOM   1278 C  CG2 . THR A 1 186 ? -29.242 -14.469 -7.343  0.35 59.50  ? 449  THR A CG2 1 
ATOM   1279 N  N   . CYS A 1 187 ? -25.169 -16.152 -9.593  0.35 52.29  ? 450  CYS A N   1 
ATOM   1280 C  CA  . CYS A 1 187 ? -24.332 -17.170 -10.294 0.35 50.46  ? 450  CYS A CA  1 
ATOM   1281 C  C   . CYS A 1 187 ? -22.951 -17.247 -9.627  0.35 48.08  ? 450  CYS A C   1 
ATOM   1282 O  O   . CYS A 1 187 ? -21.964 -16.765 -10.215 0.35 46.02  ? 450  CYS A O   1 
ATOM   1283 C  CB  . CYS A 1 187 ? -24.222 -16.878 -11.786 0.35 50.26  ? 450  CYS A CB  1 
ATOM   1284 S  SG  . CYS A 1 187 ? -25.803 -17.017 -12.662 0.35 52.64  ? 450  CYS A SG  1 
ATOM   1285 N  N   . VAL A 1 188 ? -22.904 -17.829 -8.427  0.35 48.95  ? 451  VAL A N   1 
ATOM   1286 C  CA  . VAL A 1 188 ? -21.670 -18.053 -7.618  0.35 51.63  ? 451  VAL A CA  1 
ATOM   1287 C  C   . VAL A 1 188 ? -21.506 -19.566 -7.420  0.35 51.27  ? 451  VAL A C   1 
ATOM   1288 O  O   . VAL A 1 188 ? -22.443 -20.199 -6.893  0.35 48.24  ? 451  VAL A O   1 
ATOM   1289 C  CB  . VAL A 1 188 ? -21.741 -17.298 -6.275  0.35 53.02  ? 451  VAL A CB  1 
ATOM   1290 C  CG1 . VAL A 1 188 ? -20.549 -17.593 -5.375  0.35 53.65  ? 451  VAL A CG1 1 
ATOM   1291 C  CG2 . VAL A 1 188 ? -21.885 -15.800 -6.483  0.35 53.48  ? 451  VAL A CG2 1 
ATOM   1292 N  N   . TYR A 1 189 ? -20.360 -20.117 -7.829  0.35 51.61  ? 452  TYR A N   1 
ATOM   1293 C  CA  . TYR A 1 189 ? -20.077 -21.577 -7.809  0.35 53.30  ? 452  TYR A CA  1 
ATOM   1294 C  C   . TYR A 1 189 ? -19.869 -22.046 -6.364  0.35 52.25  ? 452  TYR A C   1 
ATOM   1295 O  O   . TYR A 1 189 ? -19.535 -21.218 -5.500  0.35 53.26  ? 452  TYR A O   1 
ATOM   1296 C  CB  . TYR A 1 189 ? -18.886 -21.908 -8.713  0.35 51.83  ? 452  TYR A CB  1 
ATOM   1297 C  CG  . TYR A 1 189 ? -19.198 -21.823 -10.186 0.35 50.71  ? 452  TYR A CG  1 
ATOM   1298 C  CD1 . TYR A 1 189 ? -19.952 -22.804 -10.809 0.35 50.87  ? 452  TYR A CD1 1 
ATOM   1299 C  CD2 . TYR A 1 189 ? -18.763 -20.756 -10.956 0.35 50.67  ? 452  TYR A CD2 1 
ATOM   1300 C  CE1 . TYR A 1 189 ? -20.260 -22.730 -12.158 0.35 51.12  ? 452  TYR A CE1 1 
ATOM   1301 C  CE2 . TYR A 1 189 ? -19.057 -20.672 -12.309 0.35 50.99  ? 452  TYR A CE2 1 
ATOM   1302 C  CZ  . TYR A 1 189 ? -19.812 -21.661 -12.913 0.35 49.92  ? 452  TYR A CZ  1 
ATOM   1303 O  OH  . TYR A 1 189 ? -20.120 -21.592 -14.242 0.35 50.97  ? 452  TYR A OH  1 
ATOM   1304 N  N   . ASN A 1 190 ? -20.105 -23.338 -6.120  0.35 54.14  ? 453  ASN A N   1 
ATOM   1305 C  CA  . ASN A 1 190 ? -19.853 -24.044 -4.834  0.35 55.58  ? 453  ASN A CA  1 
ATOM   1306 C  C   . ASN A 1 190 ? -18.781 -25.118 -5.080  0.35 55.64  ? 453  ASN A C   1 
ATOM   1307 O  O   . ASN A 1 190 ? -19.023 -25.995 -5.932  0.35 50.94  ? 453  ASN A O   1 
ATOM   1308 C  CB  . ASN A 1 190 ? -21.146 -24.643 -4.270  0.35 54.92  ? 453  ASN A CB  1 
ATOM   1309 C  CG  . ASN A 1 190 ? -22.119 -23.610 -3.735  0.35 55.31  ? 453  ASN A CG  1 
ATOM   1310 O  OD1 . ASN A 1 190 ? -22.931 -23.909 -2.863  0.35 54.48  ? 453  ASN A OD1 1 
ATOM   1311 N  ND2 . ASN A 1 190 ? -22.058 -22.393 -4.248  0.35 56.34  ? 453  ASN A ND2 1 
ATOM   1312 N  N   . MET A 1 191 ? -17.642 -25.044 -4.380  0.35 59.70  ? 454  MET A N   1 
ATOM   1313 C  CA  . MET A 1 191 ? -16.436 -25.884 -4.638  0.35 65.41  ? 454  MET A CA  1 
ATOM   1314 C  C   . MET A 1 191 ? -16.175 -26.832 -3.459  0.35 68.19  ? 454  MET A C   1 
ATOM   1315 O  O   . MET A 1 191 ? -16.041 -26.333 -2.324  0.35 69.49  ? 454  MET A O   1 
ATOM   1316 C  CB  . MET A 1 191 ? -15.195 -25.009 -4.852  0.35 66.94  ? 454  MET A CB  1 
ATOM   1317 C  CG  . MET A 1 191 ? -13.933 -25.802 -5.164  0.35 68.55  ? 454  MET A CG  1 
ATOM   1318 S  SD  . MET A 1 191 ? -12.461 -24.760 -5.351  0.35 71.35  ? 454  MET A SD  1 
ATOM   1319 C  CE  . MET A 1 191 ? -12.773 -24.029 -6.957  0.35 70.19  ? 454  MET A CE  1 
ATOM   1320 N  N   . MET A 1 192 ? -16.087 -28.141 -3.739  0.35 71.43  ? 455  MET A N   1 
ATOM   1321 C  CA  . MET A 1 192 ? -15.595 -29.199 -2.810  0.35 72.68  ? 455  MET A CA  1 
ATOM   1322 C  C   . MET A 1 192 ? -14.520 -30.038 -3.515  0.35 74.56  ? 455  MET A C   1 
ATOM   1323 O  O   . MET A 1 192 ? -14.252 -29.753 -4.703  0.35 76.69  ? 455  MET A O   1 
ATOM   1324 C  CB  . MET A 1 192 ? -16.728 -30.124 -2.349  0.35 72.67  ? 455  MET A CB  1 
ATOM   1325 C  CG  . MET A 1 192 ? -17.490 -29.600 -1.148  0.35 72.03  ? 455  MET A CG  1 
ATOM   1326 S  SD  . MET A 1 192 ? -18.318 -30.902 -0.196  0.35 71.72  ? 455  MET A SD  1 
ATOM   1327 C  CE  . MET A 1 192 ? -19.190 -31.780 -1.493  0.35 72.10  ? 455  MET A CE  1 
ATOM   1328 N  N   . ALA A 1 210 ? -11.253 -31.038 -7.853  0.35 62.32  ? 473  ALA A N   1 
ATOM   1329 C  CA  . ALA A 1 210 ? -12.225 -29.988 -7.459  0.35 63.20  ? 473  ALA A CA  1 
ATOM   1330 C  C   . ALA A 1 210 ? -13.413 -29.980 -8.435  0.35 62.42  ? 473  ALA A C   1 
ATOM   1331 O  O   . ALA A 1 210 ? -13.171 -29.891 -9.660  0.35 59.20  ? 473  ALA A O   1 
ATOM   1332 C  CB  . ALA A 1 210 ? -11.534 -28.645 -7.416  0.35 63.09  ? 473  ALA A CB  1 
ATOM   1333 N  N   . ILE A 1 211 ? -14.640 -30.079 -7.903  0.35 60.94  ? 474  ILE A N   1 
ATOM   1334 C  CA  . ILE A 1 211 ? -15.926 -30.012 -8.665  0.35 61.39  ? 474  ILE A CA  1 
ATOM   1335 C  C   . ILE A 1 211 ? -16.669 -28.728 -8.265  0.35 60.96  ? 474  ILE A C   1 
ATOM   1336 O  O   . ILE A 1 211 ? -16.764 -28.444 -7.050  0.35 61.33  ? 474  ILE A O   1 
ATOM   1337 C  CB  . ILE A 1 211 ? -16.781 -31.278 -8.428  0.35 61.98  ? 474  ILE A CB  1 
ATOM   1338 C  CG1 . ILE A 1 211 ? -16.213 -32.498 -9.162  0.35 62.74  ? 474  ILE A CG1 1 
ATOM   1339 C  CG2 . ILE A 1 211 ? -18.235 -31.037 -8.810  0.35 62.20  ? 474  ILE A CG2 1 
ATOM   1340 C  CD1 . ILE A 1 211 ? -15.064 -33.180 -8.453  0.35 63.40  ? 474  ILE A CD1 1 
ATOM   1341 N  N   . TRP A 1 212 ? -17.177 -27.989 -9.256  0.35 59.14  ? 475  TRP A N   1 
ATOM   1342 C  CA  . TRP A 1 212 ? -17.832 -26.663 -9.093  0.35 58.80  ? 475  TRP A CA  1 
ATOM   1343 C  C   . TRP A 1 212 ? -19.342 -26.822 -9.288  0.35 59.59  ? 475  TRP A C   1 
ATOM   1344 O  O   . TRP A 1 212 ? -19.774 -26.939 -10.450 0.35 57.97  ? 475  TRP A O   1 
ATOM   1345 C  CB  . TRP A 1 212 ? -17.267 -25.641 -10.089 0.35 57.34  ? 475  TRP A CB  1 
ATOM   1346 C  CG  . TRP A 1 212 ? -15.790 -25.399 -10.022 0.35 54.41  ? 475  TRP A CG  1 
ATOM   1347 C  CD1 . TRP A 1 212 ? -14.798 -26.304 -9.776  0.35 53.75  ? 475  TRP A CD1 1 
ATOM   1348 C  CD2 . TRP A 1 212 ? -15.128 -24.151 -10.287 0.35 53.38  ? 475  TRP A CD2 1 
ATOM   1349 N  NE1 . TRP A 1 212 ? -13.573 -25.699 -9.836  0.35 53.10  ? 475  TRP A NE1 1 
ATOM   1350 C  CE2 . TRP A 1 212 ? -13.742 -24.378 -10.151 0.35 53.28  ? 475  TRP A CE2 1 
ATOM   1351 C  CE3 . TRP A 1 212 ? -15.573 -22.865 -10.610 0.35 51.94  ? 475  TRP A CE3 1 
ATOM   1352 C  CZ2 . TRP A 1 212 ? -12.801 -23.364 -10.327 0.35 53.15  ? 475  TRP A CZ2 1 
ATOM   1353 C  CZ3 . TRP A 1 212 ? -14.644 -21.864 -10.785 0.35 51.75  ? 475  TRP A CZ3 1 
ATOM   1354 C  CH2 . TRP A 1 212 ? -13.277 -22.113 -10.650 0.35 53.52  ? 475  TRP A CH2 1 
ATOM   1355 N  N   . TYR A 1 213 ? -20.068 -26.738 -8.174  0.35 63.04  ? 476  TYR A N   1 
ATOM   1356 C  CA  . TYR A 1 213 ? -21.543 -26.809 -8.224  0.35 65.11  ? 476  TYR A CA  1 
ATOM   1357 C  C   . TYR A 1 213 ? -22.101 -25.431 -8.560  0.35 65.67  ? 476  TYR A C   1 
ATOM   1358 O  O   . TYR A 1 213 ? -21.425 -24.428 -8.277  0.35 64.20  ? 476  TYR A O   1 
ATOM   1359 C  CB  . TYR A 1 213 ? -22.087 -27.251 -6.866  0.35 67.48  ? 476  TYR A CB  1 
ATOM   1360 C  CG  . TYR A 1 213 ? -21.545 -28.571 -6.381  0.35 68.84  ? 476  TYR A CG  1 
ATOM   1361 C  CD1 . TYR A 1 213 ? -22.291 -29.732 -6.486  0.35 68.17  ? 476  TYR A CD1 1 
ATOM   1362 C  CD2 . TYR A 1 213 ? -20.278 -28.665 -5.829  0.35 69.53  ? 476  TYR A CD2 1 
ATOM   1363 C  CE1 . TYR A 1 213 ? -21.797 -30.950 -6.050  0.35 68.53  ? 476  TYR A CE1 1 
ATOM   1364 C  CE2 . TYR A 1 213 ? -19.767 -29.874 -5.391  0.35 70.65  ? 476  TYR A CE2 1 
ATOM   1365 C  CZ  . TYR A 1 213 ? -20.530 -31.021 -5.502  0.35 69.41  ? 476  TYR A CZ  1 
ATOM   1366 O  OH  . TYR A 1 213 ? -20.034 -32.216 -5.070  0.35 71.96  ? 476  TYR A OH  1 
ATOM   1367 N  N   . MET A 1 214 ? -23.286 -25.394 -9.162  0.35 68.07  ? 477  MET A N   1 
ATOM   1368 C  CA  . MET A 1 214 ? -23.993 -24.120 -9.470  0.35 70.13  ? 477  MET A CA  1 
ATOM   1369 C  C   . MET A 1 214 ? -25.504 -24.362 -9.375  0.35 67.52  ? 477  MET A C   1 
ATOM   1370 O  O   . MET A 1 214 ? -25.950 -25.437 -9.818  0.35 67.51  ? 477  MET A O   1 
ATOM   1371 C  CB  . MET A 1 214 ? -23.621 -23.598 -10.864 0.35 72.48  ? 477  MET A CB  1 
ATOM   1372 C  CG  . MET A 1 214 ? -23.871 -24.587 -11.992 0.35 75.58  ? 477  MET A CG  1 
ATOM   1373 S  SD  . MET A 1 214 ? -22.872 -24.260 -13.473 0.35 79.56  ? 477  MET A SD  1 
ATOM   1374 C  CE  . MET A 1 214 ? -23.293 -22.550 -13.807 0.35 75.35  ? 477  MET A CE  1 
ATOM   1375 N  N   . TRP A 1 215 ? -26.252 -23.414 -8.798  0.35 67.44  ? 478  TRP A N   1 
ATOM   1376 C  CA  . TRP A 1 215 ? -27.715 -23.549 -8.551  0.35 67.87  ? 478  TRP A CA  1 
ATOM   1377 C  C   . TRP A 1 215 ? -28.438 -23.697 -9.896  0.35 64.40  ? 478  TRP A C   1 
ATOM   1378 O  O   . TRP A 1 215 ? -27.952 -23.131 -10.896 0.35 63.06  ? 478  TRP A O   1 
ATOM   1379 C  CB  . TRP A 1 215 ? -28.257 -22.388 -7.699  0.35 69.46  ? 478  TRP A CB  1 
ATOM   1380 C  CG  . TRP A 1 215 ? -28.771 -21.208 -8.466  0.35 72.55  ? 478  TRP A CG  1 
ATOM   1381 C  CD1 . TRP A 1 215 ? -28.046 -20.346 -9.237  0.35 75.15  ? 478  TRP A CD1 1 
ATOM   1382 C  CD2 . TRP A 1 215 ? -30.130 -20.736 -8.513  0.35 73.58  ? 478  TRP A CD2 1 
ATOM   1383 N  NE1 . TRP A 1 215 ? -28.859 -19.382 -9.771  0.35 75.72  ? 478  TRP A NE1 1 
ATOM   1384 C  CE2 . TRP A 1 215 ? -30.143 -19.594 -9.345  0.35 75.55  ? 478  TRP A CE2 1 
ATOM   1385 C  CE3 . TRP A 1 215 ? -31.333 -21.168 -7.944  0.35 74.01  ? 478  TRP A CE3 1 
ATOM   1386 C  CZ2 . TRP A 1 215 ? -31.311 -18.881 -9.615  0.35 74.13  ? 478  TRP A CZ2 1 
ATOM   1387 C  CZ3 . TRP A 1 215 ? -32.487 -20.464 -8.212  0.35 74.44  ? 478  TRP A CZ3 1 
ATOM   1388 C  CH2 . TRP A 1 215 ? -32.474 -19.338 -9.038  0.35 75.25  ? 478  TRP A CH2 1 
ATOM   1389 N  N   . LEU A 1 216 ? -29.535 -24.460 -9.917  1.00 62.60  ? 479  LEU A N   1 
ATOM   1390 C  CA  . LEU A 1 216 ? -30.220 -24.857 -11.177 1.00 64.02  ? 479  LEU A CA  1 
ATOM   1391 C  C   . LEU A 1 216 ? -30.515 -23.663 -12.102 1.00 65.89  ? 479  LEU A C   1 
ATOM   1392 O  O   . LEU A 1 216 ? -30.389 -23.834 -13.323 1.00 72.58  ? 479  LEU A O   1 
ATOM   1393 C  CB  . LEU A 1 216 ? -31.508 -25.580 -10.797 1.00 64.46  ? 479  LEU A CB  1 
ATOM   1394 C  CG  . LEU A 1 216 ? -31.930 -26.655 -11.779 1.00 65.40  ? 479  LEU A CG  1 
ATOM   1395 C  CD1 . LEU A 1 216 ? -30.920 -27.791 -11.787 1.00 66.73  ? 479  LEU A CD1 1 
ATOM   1396 C  CD2 . LEU A 1 216 ? -33.323 -27.148 -11.439 1.00 71.53  ? 479  LEU A CD2 1 
ATOM   1397 N  N   . GLY A 1 217 ? -30.879 -22.498 -11.562 1.00 57.10  ? 480  GLY A N   1 
ATOM   1398 C  CA  . GLY A 1 217 ? -31.201 -21.313 -12.377 1.00 60.42  ? 480  GLY A CA  1 
ATOM   1399 C  C   . GLY A 1 217 ? -30.046 -20.898 -13.266 1.00 54.37  ? 480  GLY A C   1 
ATOM   1400 O  O   . GLY A 1 217 ? -30.267 -20.752 -14.478 1.00 57.43  ? 480  GLY A O   1 
ATOM   1401 N  N   . ALA A 1 218 ? -28.859 -20.739 -12.677 1.00 57.35  ? 481  ALA A N   1 
ATOM   1402 C  CA  . ALA A 1 218 ? -27.574 -20.417 -13.353 1.00 56.38  ? 481  ALA A CA  1 
ATOM   1403 C  C   . ALA A 1 218 ? -27.240 -21.490 -14.400 1.00 52.43  ? 481  ALA A C   1 
ATOM   1404 O  O   . ALA A 1 218 ? -26.791 -21.133 -15.511 1.00 51.78  ? 481  ALA A O   1 
ATOM   1405 C  CB  . ALA A 1 218 ? -26.492 -20.336 -12.327 1.00 55.10  ? 481  ALA A CB  1 
ATOM   1406 N  N   . ARG A 1 219 ? -27.431 -22.761 -14.025 0.35 52.19  ? 482  ARG A N   1 
ATOM   1407 C  CA  . ARG A 1 219 ? -27.309 -23.957 -14.907 0.35 52.92  ? 482  ARG A CA  1 
ATOM   1408 C  C   . ARG A 1 219 ? -28.215 -23.767 -16.129 0.35 52.51  ? 482  ARG A C   1 
ATOM   1409 O  O   . ARG A 1 219 ? -27.726 -23.969 -17.262 0.35 51.34  ? 482  ARG A O   1 
ATOM   1410 C  CB  . ARG A 1 219 ? -27.663 -25.236 -14.136 0.35 52.64  ? 482  ARG A CB  1 
ATOM   1411 C  CG  . ARG A 1 219 ? -28.314 -26.334 -14.971 0.35 55.31  ? 482  ARG A CG  1 
ATOM   1412 C  CD  . ARG A 1 219 ? -27.393 -27.436 -15.469 0.35 55.15  ? 482  ARG A CD  1 
ATOM   1413 N  NE  . ARG A 1 219 ? -25.994 -27.048 -15.438 0.35 55.95  ? 482  ARG A NE  1 
ATOM   1414 C  CZ  . ARG A 1 219 ? -25.334 -26.429 -16.411 0.35 56.37  ? 482  ARG A CZ  1 
ATOM   1415 N  NH1 . ARG A 1 219 ? -24.063 -26.126 -16.221 0.35 57.25  ? 482  ARG A NH1 1 
ATOM   1416 N  NH2 . ARG A 1 219 ? -25.920 -26.110 -17.554 0.35 56.36  ? 482  ARG A NH2 1 
ATOM   1417 N  N   . PHE A 1 220 ? -29.480 -23.393 -15.896 1.00 53.13  ? 483  PHE A N   1 
ATOM   1418 C  CA  . PHE A 1 220 ? -30.481 -23.162 -16.964 1.00 45.82  ? 483  PHE A CA  1 
ATOM   1419 C  C   . PHE A 1 220 ? -29.954 -22.094 -17.924 1.00 42.68  ? 483  PHE A C   1 
ATOM   1420 O  O   . PHE A 1 220 ? -29.956 -22.330 -19.129 1.00 48.46  ? 483  PHE A O   1 
ATOM   1421 C  CB  . PHE A 1 220 ? -31.861 -22.723 -16.456 1.00 43.03  ? 483  PHE A CB  1 
ATOM   1422 C  CG  . PHE A 1 220 ? -32.724 -22.373 -17.636 1.00 39.95  ? 483  PHE A CG  1 
ATOM   1423 C  CD1 . PHE A 1 220 ? -33.121 -23.358 -18.522 1.00 44.21  ? 483  PHE A CD1 1 
ATOM   1424 C  CD2 . PHE A 1 220 ? -32.926 -21.053 -17.995 1.00 46.06  ? 483  PHE A CD2 1 
ATOM   1425 C  CE1 . PHE A 1 220 ? -33.820 -23.034 -19.673 1.00 48.73  ? 483  PHE A CE1 1 
ATOM   1426 C  CE2 . PHE A 1 220 ? -33.618 -20.728 -19.158 1.00 44.64  ? 483  PHE A CE2 1 
ATOM   1427 C  CZ  . PHE A 1 220 ? -34.067 -21.720 -19.989 1.00 45.61  ? 483  PHE A CZ  1 
ATOM   1428 N  N   . LEU A 1 221 ? -29.523 -20.952 -17.391 1.00 47.26  ? 484  LEU A N   1 
ATOM   1429 C  CA  . LEU A 1 221 ? -29.051 -19.798 -18.203 1.00 49.87  ? 484  LEU A CA  1 
ATOM   1430 C  C   . LEU A 1 221 ? -27.812 -20.207 -19.007 1.00 49.66  ? 484  LEU A C   1 
ATOM   1431 O  O   . LEU A 1 221 ? -27.675 -19.779 -20.192 1.00 43.80  ? 484  LEU A O   1 
ATOM   1432 C  CB  . LEU A 1 221 ? -28.778 -18.602 -17.281 1.00 50.29  ? 484  LEU A CB  1 
ATOM   1433 C  CG  . LEU A 1 221 ? -30.020 -17.862 -16.759 1.00 51.97  ? 484  LEU A CG  1 
ATOM   1434 C  CD1 . LEU A 1 221 ? -29.627 -16.725 -15.816 1.00 53.37  ? 484  LEU A CD1 1 
ATOM   1435 C  CD2 . LEU A 1 221 ? -30.859 -17.302 -17.900 1.00 52.02  ? 484  LEU A CD2 1 
ATOM   1436 N  N   . GLU A 1 222 ? -26.931 -21.016 -18.413 1.00 48.25  ? 485  GLU A N   1 
ATOM   1437 C  CA  . GLU A 1 222 ? -25.751 -21.526 -19.157 1.00 45.79  ? 485  GLU A CA  1 
ATOM   1438 C  C   . GLU A 1 222 ? -26.243 -22.404 -20.316 1.00 39.32  ? 485  GLU A C   1 
ATOM   1439 O  O   . GLU A 1 222 ? -25.800 -22.181 -21.477 1.00 42.27  ? 485  GLU A O   1 
ATOM   1440 C  CB  . GLU A 1 222 ? -24.794 -22.238 -18.200 1.00 48.22  ? 485  GLU A CB  1 
ATOM   1441 C  CG  . GLU A 1 222 ? -23.571 -22.734 -18.929 1.00 53.28  ? 485  GLU A CG  1 
ATOM   1442 C  CD  . GLU A 1 222 ? -22.712 -23.687 -18.142 1.00 48.74  ? 485  GLU A CD  1 
ATOM   1443 O  OE1 . GLU A 1 222 ? -21.561 -23.309 -17.834 1.00 44.63  ? 485  GLU A OE1 1 
ATOM   1444 O  OE2 . GLU A 1 222 ? -23.191 -24.806 -17.911 1.00 46.69  ? 485  GLU A OE2 1 
ATOM   1445 N  N   . PHE A 1 223 ? -27.173 -23.324 -20.036 1.00 42.00  ? 486  PHE A N   1 
ATOM   1446 C  CA  . PHE A 1 223 ? -27.767 -24.278 -21.012 1.00 42.78  ? 486  PHE A CA  1 
ATOM   1447 C  C   . PHE A 1 223 ? -28.487 -23.519 -22.124 1.00 47.27  ? 486  PHE A C   1 
ATOM   1448 O  O   . PHE A 1 223 ? -28.357 -23.916 -23.299 1.00 44.59  ? 486  PHE A O   1 
ATOM   1449 C  CB  . PHE A 1 223 ? -28.714 -25.247 -20.310 1.00 46.17  ? 486  PHE A CB  1 
ATOM   1450 C  CG  . PHE A 1 223 ? -29.468 -26.194 -21.215 1.00 49.40  ? 486  PHE A CG  1 
ATOM   1451 C  CD1 . PHE A 1 223 ? -28.841 -27.306 -21.758 1.00 45.75  ? 486  PHE A CD1 1 
ATOM   1452 C  CD2 . PHE A 1 223 ? -30.818 -25.990 -21.487 1.00 47.10  ? 486  PHE A CD2 1 
ATOM   1453 C  CE1 . PHE A 1 223 ? -29.536 -28.171 -22.594 1.00 50.71  ? 486  PHE A CE1 1 
ATOM   1454 C  CE2 . PHE A 1 223 ? -31.513 -26.870 -22.297 1.00 46.45  ? 486  PHE A CE2 1 
ATOM   1455 C  CZ  . PHE A 1 223 ? -30.874 -27.955 -22.857 1.00 50.47  ? 486  PHE A CZ  1 
ATOM   1456 N  N   . GLU A 1 224 ? -29.179 -22.436 -21.771 1.00 49.13  ? 487  GLU A N   1 
ATOM   1457 C  CA  . GLU A 1 224 ? -29.963 -21.613 -22.730 1.00 51.36  ? 487  GLU A CA  1 
ATOM   1458 C  C   . GLU A 1 224 ? -29.015 -21.010 -23.770 1.00 49.29  ? 487  GLU A C   1 
ATOM   1459 O  O   . GLU A 1 224 ? -29.364 -20.954 -24.986 1.00 44.29  ? 487  GLU A O   1 
ATOM   1460 C  CB  . GLU A 1 224 ? -30.719 -20.512 -21.981 1.00 60.51  ? 487  GLU A CB  1 
ATOM   1461 C  CG  . GLU A 1 224 ? -31.316 -19.455 -22.894 1.00 63.71  ? 487  GLU A CG  1 
ATOM   1462 C  CD  . GLU A 1 224 ? -32.399 -18.619 -22.229 1.00 65.88  ? 487  GLU A CD  1 
ATOM   1463 O  OE1 . GLU A 1 224 ? -33.589 -18.927 -22.456 1.00 60.82  ? 487  GLU A OE1 1 
ATOM   1464 O  OE2 . GLU A 1 224 ? -32.044 -17.678 -21.489 1.00 53.85  ? 487  GLU A OE2 1 
ATOM   1465 N  N   . ALA A 1 225 ? -27.841 -20.591 -23.314 1.00 43.40  ? 488  ALA A N   1 
ATOM   1466 C  CA  . ALA A 1 225 ? -26.907 -19.777 -24.113 1.00 44.45  ? 488  ALA A CA  1 
ATOM   1467 C  C   . ALA A 1 225 ? -25.953 -20.676 -24.905 1.00 42.85  ? 488  ALA A C   1 
ATOM   1468 O  O   . ALA A 1 225 ? -25.565 -20.251 -26.042 1.00 38.36  ? 488  ALA A O   1 
ATOM   1469 C  CB  . ALA A 1 225 ? -26.171 -18.816 -23.214 1.00 45.41  ? 488  ALA A CB  1 
ATOM   1470 N  N   . LEU A 1 226 ? -25.559 -21.820 -24.329 1.00 39.98  ? 489  LEU A N   1 
ATOM   1471 C  CA  . LEU A 1 226 ? -24.378 -22.613 -24.799 1.00 39.28  ? 489  LEU A CA  1 
ATOM   1472 C  C   . LEU A 1 226 ? -24.722 -24.096 -25.005 1.00 36.55  ? 489  LEU A C   1 
ATOM   1473 O  O   . LEU A 1 226 ? -23.887 -24.825 -25.604 1.00 37.58  ? 489  LEU A O   1 
ATOM   1474 C  CB  . LEU A 1 226 ? -23.244 -22.401 -23.783 1.00 36.27  ? 489  LEU A CB  1 
ATOM   1475 C  CG  . LEU A 1 226 ? -22.714 -20.970 -23.699 1.00 40.16  ? 489  LEU A CG  1 
ATOM   1476 C  CD1 . LEU A 1 226 ? -21.578 -20.822 -22.668 1.00 41.54  ? 489  LEU A CD1 1 
ATOM   1477 C  CD2 . LEU A 1 226 ? -22.224 -20.491 -25.070 1.00 41.02  ? 489  LEU A CD2 1 
ATOM   1478 N  N   . GLY A 1 227 ? -25.895 -24.547 -24.542 1.00 32.50  ? 490  GLY A N   1 
ATOM   1479 C  CA  . GLY A 1 227 ? -26.383 -25.933 -24.674 1.00 32.70  ? 490  GLY A CA  1 
ATOM   1480 C  C   . GLY A 1 227 ? -26.317 -26.441 -26.103 1.00 29.54  ? 490  GLY A C   1 
ATOM   1481 O  O   . GLY A 1 227 ? -26.093 -27.646 -26.314 1.00 35.49  ? 490  GLY A O   1 
ATOM   1482 N  N   . PHE A 1 228 ? -26.438 -25.557 -27.081 1.00 32.58  ? 491  PHE A N   1 
ATOM   1483 C  CA  . PHE A 1 228 ? -26.510 -25.949 -28.516 1.00 33.72  ? 491  PHE A CA  1 
ATOM   1484 C  C   . PHE A 1 228 ? -25.239 -26.697 -28.970 1.00 30.72  ? 491  PHE A C   1 
ATOM   1485 O  O   . PHE A 1 228 ? -25.329 -27.517 -29.892 1.00 31.35  ? 491  PHE A O   1 
ATOM   1486 C  CB  . PHE A 1 228 ? -26.758 -24.721 -29.393 1.00 33.70  ? 491  PHE A CB  1 
ATOM   1487 C  CG  . PHE A 1 228 ? -25.601 -23.786 -29.539 1.00 30.74  ? 491  PHE A CG  1 
ATOM   1488 C  CD1 . PHE A 1 228 ? -25.395 -22.773 -28.625 1.00 35.11  ? 491  PHE A CD1 1 
ATOM   1489 C  CD2 . PHE A 1 228 ? -24.718 -23.916 -30.598 1.00 34.96  ? 491  PHE A CD2 1 
ATOM   1490 C  CE1 . PHE A 1 228 ? -24.326 -21.909 -28.756 1.00 34.36  ? 491  PHE A CE1 1 
ATOM   1491 C  CE2 . PHE A 1 228 ? -23.646 -23.046 -30.730 1.00 32.68  ? 491  PHE A CE2 1 
ATOM   1492 C  CZ  . PHE A 1 228 ? -23.421 -22.080 -29.788 1.00 32.78  ? 491  PHE A CZ  1 
ATOM   1493 N  N   . LEU A 1 229 ? -24.085 -26.378 -28.379 1.00 36.06  ? 492  LEU A N   1 
ATOM   1494 C  CA  . LEU A 1 229 ? -22.758 -26.995 -28.686 1.00 36.05  ? 492  LEU A CA  1 
ATOM   1495 C  C   . LEU A 1 229 ? -22.841 -28.523 -28.524 1.00 32.63  ? 492  LEU A C   1 
ATOM   1496 O  O   . LEU A 1 229 ? -22.490 -29.272 -29.490 1.00 34.15  ? 492  LEU A O   1 
ATOM   1497 C  CB  . LEU A 1 229 ? -21.707 -26.344 -27.764 1.00 35.51  ? 492  LEU A CB  1 
ATOM   1498 C  CG  . LEU A 1 229 ? -21.251 -24.921 -28.143 1.00 34.71  ? 492  LEU A CG  1 
ATOM   1499 C  CD1 . LEU A 1 229 ? -20.306 -24.382 -27.100 1.00 36.02  ? 492  LEU A CD1 1 
ATOM   1500 C  CD2 . LEU A 1 229 ? -20.603 -24.834 -29.523 1.00 34.31  ? 492  LEU A CD2 1 
ATOM   1501 N  N   . ASN A 1 230 ? -23.394 -28.965 -27.397 1.00 32.40  ? 493  ASN A N   1 
ATOM   1502 C  CA  . ASN A 1 230 ? -23.668 -30.394 -27.094 1.00 33.74  ? 493  ASN A CA  1 
ATOM   1503 C  C   . ASN A 1 230 ? -24.928 -30.889 -27.828 1.00 37.00  ? 493  ASN A C   1 
ATOM   1504 O  O   . ASN A 1 230 ? -24.844 -31.881 -28.619 1.00 36.68  ? 493  ASN A O   1 
ATOM   1505 C  CB  . ASN A 1 230 ? -23.798 -30.626 -25.582 1.00 36.37  ? 493  ASN A CB  1 
ATOM   1506 C  CG  . ASN A 1 230 ? -23.923 -32.111 -25.319 1.00 43.26  ? 493  ASN A CG  1 
ATOM   1507 O  OD1 . ASN A 1 230 ? -24.961 -32.613 -24.856 1.00 45.10  ? 493  ASN A OD1 1 
ATOM   1508 N  ND2 . ASN A 1 230 ? -22.912 -32.837 -25.777 1.00 41.95  ? 493  ASN A ND2 1 
ATOM   1509 N  N   . GLU A 1 231 ? -26.066 -30.216 -27.598 1.00 39.73  ? 494  GLU A N   1 
ATOM   1510 C  CA  . GLU A 1 231 ? -27.402 -30.645 -28.093 1.00 34.14  ? 494  GLU A CA  1 
ATOM   1511 C  C   . GLU A 1 231 ? -27.408 -30.786 -29.613 1.00 34.33  ? 494  GLU A C   1 
ATOM   1512 O  O   . GLU A 1 231 ? -28.101 -31.691 -30.022 1.00 32.21  ? 494  GLU A O   1 
ATOM   1513 C  CB  . GLU A 1 231 ? -28.494 -29.646 -27.708 1.00 39.74  ? 494  GLU A CB  1 
ATOM   1514 C  CG  . GLU A 1 231 ? -28.849 -29.620 -26.229 1.00 37.17  ? 494  GLU A CG  1 
ATOM   1515 C  CD  . GLU A 1 231 ? -29.382 -30.915 -25.662 1.00 40.72  ? 494  GLU A CD  1 
ATOM   1516 O  OE1 . GLU A 1 231 ? -30.277 -31.529 -26.280 1.00 45.72  ? 494  GLU A OE1 1 
ATOM   1517 O  OE2 . GLU A 1 231 ? -28.884 -31.298 -24.612 1.00 53.59  ? 494  GLU A OE2 1 
ATOM   1518 N  N   . ASP A 1 232 ? -26.691 -29.946 -30.398 1.00 33.02  ? 495  ASP A N   1 
ATOM   1519 C  CA  . ASP A 1 232 ? -26.664 -30.067 -31.889 1.00 33.45  ? 495  ASP A CA  1 
ATOM   1520 C  C   . ASP A 1 232 ? -25.295 -30.585 -32.387 1.00 36.33  ? 495  ASP A C   1 
ATOM   1521 O  O   . ASP A 1 232 ? -25.011 -30.514 -33.625 1.00 33.08  ? 495  ASP A O   1 
ATOM   1522 C  CB  . ASP A 1 232 ? -27.066 -28.748 -32.561 1.00 36.63  ? 495  ASP A CB  1 
ATOM   1523 C  CG  . ASP A 1 232 ? -28.370 -28.158 -32.040 1.00 34.11  ? 495  ASP A CG  1 
ATOM   1524 O  OD1 . ASP A 1 232 ? -29.165 -28.921 -31.524 1.00 39.40  ? 495  ASP A OD1 1 
ATOM   1525 O  OD2 . ASP A 1 232 ? -28.500 -26.945 -32.042 1.00 35.49  ? 495  ASP A OD2 1 
ATOM   1526 N  N   . HIS A 1 233 ? -24.490 -31.180 -31.506 1.00 34.92  ? 496  HIS A N   1 
ATOM   1527 C  CA  . HIS A 1 233 ? -23.343 -32.044 -31.911 1.00 36.45  ? 496  HIS A CA  1 
ATOM   1528 C  C   . HIS A 1 233 ? -22.312 -31.241 -32.704 1.00 29.93  ? 496  HIS A C   1 
ATOM   1529 O  O   . HIS A 1 233 ? -21.918 -31.696 -33.796 1.00 29.90  ? 496  HIS A O   1 
ATOM   1530 C  CB  . HIS A 1 233 ? -23.835 -33.236 -32.736 1.00 36.21  ? 496  HIS A CB  1 
ATOM   1531 C  CG  . HIS A 1 233 ? -24.938 -33.960 -32.077 1.00 39.15  ? 496  HIS A CG  1 
ATOM   1532 N  ND1 . HIS A 1 233 ? -24.788 -34.535 -30.841 1.00 46.11  ? 496  HIS A ND1 1 
ATOM   1533 C  CD2 . HIS A 1 233 ? -26.237 -34.129 -32.427 1.00 47.26  ? 496  HIS A CD2 1 
ATOM   1534 C  CE1 . HIS A 1 233 ? -25.943 -35.075 -30.465 1.00 43.79  ? 496  HIS A CE1 1 
ATOM   1535 N  NE2 . HIS A 1 233 ? -26.832 -34.847 -31.424 1.00 43.42  ? 496  HIS A NE2 1 
ATOM   1536 N  N   . TRP A 1 234 ? -21.851 -30.133 -32.136 1.00 30.45  ? 497  TRP A N   1 
ATOM   1537 C  CA  . TRP A 1 234 ? -20.808 -29.250 -32.737 1.00 32.80  ? 497  TRP A CA  1 
ATOM   1538 C  C   . TRP A 1 234 ? -19.479 -30.025 -32.827 1.00 33.10  ? 497  TRP A C   1 
ATOM   1539 O  O   . TRP A 1 234 ? -18.753 -29.893 -33.874 1.00 28.77  ? 497  TRP A O   1 
ATOM   1540 C  CB  . TRP A 1 234 ? -20.719 -27.906 -31.991 1.00 34.77  ? 497  TRP A CB  1 
ATOM   1541 C  CG  . TRP A 1 234 ? -21.745 -26.946 -32.529 1.00 41.52  ? 497  TRP A CG  1 
ATOM   1542 C  CD1 . TRP A 1 234 ? -23.076 -27.218 -32.691 1.00 42.97  ? 497  TRP A CD1 1 
ATOM   1543 C  CD2 . TRP A 1 234 ? -21.541 -25.638 -33.102 1.00 41.12  ? 497  TRP A CD2 1 
ATOM   1544 N  NE1 . TRP A 1 234 ? -23.712 -26.171 -33.297 1.00 41.40  ? 497  TRP A NE1 1 
ATOM   1545 C  CE2 . TRP A 1 234 ? -22.808 -25.181 -33.556 1.00 44.87  ? 497  TRP A CE2 1 
ATOM   1546 C  CE3 . TRP A 1 234 ? -20.435 -24.789 -33.263 1.00 39.46  ? 497  TRP A CE3 1 
ATOM   1547 C  CZ2 . TRP A 1 234 ? -23.001 -23.922 -34.140 1.00 39.40  ? 497  TRP A CZ2 1 
ATOM   1548 C  CZ3 . TRP A 1 234 ? -20.624 -23.552 -33.853 1.00 42.73  ? 497  TRP A CZ3 1 
ATOM   1549 C  CH2 . TRP A 1 234 ? -21.888 -23.127 -34.297 1.00 39.30  ? 497  TRP A CH2 1 
ATOM   1550 N  N   . PHE A 1 235 ? -19.263 -30.949 -31.887 1.00 29.20  ? 498  PHE A N   1 
ATOM   1551 C  CA  . PHE A 1 235 ? -18.021 -31.738 -31.784 1.00 31.05  ? 498  PHE A CA  1 
ATOM   1552 C  C   . PHE A 1 235 ? -18.150 -33.176 -32.307 1.00 31.79  ? 498  PHE A C   1 
ATOM   1553 O  O   . PHE A 1 235 ? -17.260 -33.982 -32.040 1.00 34.63  ? 498  PHE A O   1 
ATOM   1554 C  CB  . PHE A 1 235 ? -17.485 -31.536 -30.371 1.00 28.76  ? 498  PHE A CB  1 
ATOM   1555 C  CG  . PHE A 1 235 ? -17.125 -30.095 -30.185 1.00 32.36  ? 498  PHE A CG  1 
ATOM   1556 C  CD1 . PHE A 1 235 ? -16.093 -29.537 -30.941 1.00 34.45  ? 498  PHE A CD1 1 
ATOM   1557 C  CD2 . PHE A 1 235 ? -17.911 -29.262 -29.404 1.00 31.06  ? 498  PHE A CD2 1 
ATOM   1558 C  CE1 . PHE A 1 235 ? -15.795 -28.189 -30.836 1.00 34.59  ? 498  PHE A CE1 1 
ATOM   1559 C  CE2 . PHE A 1 235 ? -17.607 -27.908 -29.309 1.00 33.05  ? 498  PHE A CE2 1 
ATOM   1560 C  CZ  . PHE A 1 235 ? -16.566 -27.371 -30.024 1.00 33.47  ? 498  PHE A CZ  1 
ATOM   1561 N  N   . SER A 1 236 ? -19.210 -33.483 -33.064 0.50 31.64  ? 499  SER A N   1 
ATOM   1562 C  CA  . SER A 1 236 ? -19.342 -34.767 -33.802 0.50 31.69  ? 499  SER A CA  1 
ATOM   1563 C  C   . SER A 1 236 ? -18.142 -34.904 -34.745 0.50 31.64  ? 499  SER A C   1 
ATOM   1564 O  O   . SER A 1 236 ? -17.629 -33.863 -35.206 0.50 32.27  ? 499  SER A O   1 
ATOM   1565 C  CB  . SER A 1 236 ? -20.648 -34.858 -34.566 0.50 32.12  ? 499  SER A CB  1 
ATOM   1566 O  OG  . SER A 1 236 ? -20.463 -34.611 -35.960 0.50 31.06  ? 499  SER A OG  1 
ATOM   1567 N  N   . ARG A 1 237 ? -17.718 -36.132 -35.038 1.00 30.76  ? 500  ARG A N   1 
ATOM   1568 C  CA  . ARG A 1 237 ? -16.613 -36.350 -35.993 1.00 32.06  ? 500  ARG A CA  1 
ATOM   1569 C  C   . ARG A 1 237 ? -16.995 -35.738 -37.344 1.00 34.19  ? 500  ARG A C   1 
ATOM   1570 O  O   . ARG A 1 237 ? -16.143 -35.035 -37.948 1.00 31.37  ? 500  ARG A O   1 
ATOM   1571 C  CB  . ARG A 1 237 ? -16.201 -37.806 -36.149 1.00 33.90  ? 500  ARG A CB  1 
ATOM   1572 C  CG  . ARG A 1 237 ? -14.823 -37.943 -36.777 1.00 30.79  ? 500  ARG A CG  1 
ATOM   1573 C  CD  . ARG A 1 237 ? -14.069 -39.112 -36.211 1.00 32.13  ? 500  ARG A CD  1 
ATOM   1574 N  NE  . ARG A 1 237 ? -12.718 -39.066 -36.720 1.00 31.16  ? 500  ARG A NE  1 
ATOM   1575 C  CZ  . ARG A 1 237 ? -11.706 -38.437 -36.139 1.00 28.40  ? 500  ARG A CZ  1 
ATOM   1576 N  NH1 . ARG A 1 237 ? -11.882 -37.766 -35.008 1.00 24.86  ? 500  ARG A NH1 1 
ATOM   1577 N  NH2 . ARG A 1 237 ? -10.515 -38.477 -36.724 1.00 27.77  ? 500  ARG A NH2 1 
ATOM   1578 N  N   . GLU A 1 238 ? -18.230 -35.932 -37.793 1.00 36.16  ? 501  GLU A N   1 
ATOM   1579 C  CA  . GLU A 1 238 ? -18.670 -35.449 -39.135 1.00 34.74  ? 501  GLU A CA  1 
ATOM   1580 C  C   . GLU A 1 238 ? -18.542 -33.939 -39.157 1.00 30.50  ? 501  GLU A C   1 
ATOM   1581 O  O   . GLU A 1 238 ? -18.091 -33.364 -40.153 1.00 30.53  ? 501  GLU A O   1 
ATOM   1582 C  CB  . GLU A 1 238 ? -20.113 -35.872 -39.469 1.00 43.08  ? 501  GLU A CB  1 
ATOM   1583 C  CG  . GLU A 1 238 ? -20.617 -35.258 -40.763 1.00 49.06  ? 501  GLU A CG  1 
ATOM   1584 C  CD  . GLU A 1 238 ? -22.089 -35.452 -41.101 1.00 62.99  ? 501  GLU A CD  1 
ATOM   1585 O  OE1 . GLU A 1 238 ? -22.769 -34.416 -41.305 1.00 71.67  ? 501  GLU A OE1 1 
ATOM   1586 O  OE2 . GLU A 1 238 ? -22.551 -36.624 -41.190 1.00 57.70  ? 501  GLU A OE2 1 
ATOM   1587 N  N   . ASN A 1 239 ? -18.927 -33.278 -38.086 1.00 32.17  ? 502  ASN A N   1 
ATOM   1588 C  CA  . ASN A 1 239 ? -18.915 -31.803 -38.108 1.00 32.39  ? 502  ASN A CA  1 
ATOM   1589 C  C   . ASN A 1 239 ? -17.532 -31.183 -37.830 1.00 33.53  ? 502  ASN A C   1 
ATOM   1590 O  O   . ASN A 1 239 ? -17.298 -30.124 -38.406 1.00 31.32  ? 502  ASN A O   1 
ATOM   1591 C  CB  . ASN A 1 239 ? -19.927 -31.192 -37.149 1.00 33.78  ? 502  ASN A CB  1 
ATOM   1592 C  CG  . ASN A 1 239 ? -20.116 -29.732 -37.484 1.00 37.52  ? 502  ASN A CG  1 
ATOM   1593 O  OD1 . ASN A 1 239 ? -20.510 -29.408 -38.618 1.00 35.91  ? 502  ASN A OD1 1 
ATOM   1594 N  ND2 . ASN A 1 239 ? -19.752 -28.860 -36.550 1.00 35.34  ? 502  ASN A ND2 1 
ATOM   1595 N  N   . SER A 1 240 ? -16.734 -31.682 -36.871 1.00 29.47  ? 503  SER A N   1 
ATOM   1596 C  CA  . SER A 1 240 ? -15.464 -31.036 -36.401 1.00 28.22  ? 503  SER A CA  1 
ATOM   1597 C  C   . SER A 1 240 ? -14.182 -31.737 -36.898 1.00 27.74  ? 503  SER A C   1 
ATOM   1598 O  O   . SER A 1 240 ? -13.121 -31.140 -36.692 1.00 30.61  ? 503  SER A O   1 
ATOM   1599 C  CB  . SER A 1 240 ? -15.439 -30.946 -34.913 1.00 29.14  ? 503  SER A CB  1 
ATOM   1600 O  OG  . SER A 1 240 ? -15.349 -32.260 -34.315 1.00 29.51  ? 503  SER A OG  1 
ATOM   1601 N  N   . LEU A 1 241 ? -14.263 -32.936 -37.490 1.00 31.04  ? 504  LEU A N   1 
ATOM   1602 C  CA  . LEU A 1 241 ? -13.182 -33.749 -38.134 1.00 31.16  ? 504  LEU A CA  1 
ATOM   1603 C  C   . LEU A 1 241 ? -12.238 -34.369 -37.079 1.00 33.00  ? 504  LEU A C   1 
ATOM   1604 O  O   . LEU A 1 241 ? -11.808 -35.504 -37.284 1.00 30.78  ? 504  LEU A O   1 
ATOM   1605 C  CB  . LEU A 1 241 ? -12.414 -32.892 -39.143 1.00 35.35  ? 504  LEU A CB  1 
ATOM   1606 C  CG  . LEU A 1 241 ? -13.192 -32.304 -40.334 1.00 39.97  ? 504  LEU A CG  1 
ATOM   1607 C  CD1 . LEU A 1 241 ? -12.241 -31.900 -41.451 1.00 39.14  ? 504  LEU A CD1 1 
ATOM   1608 C  CD2 . LEU A 1 241 ? -14.187 -33.271 -40.910 1.00 45.54  ? 504  LEU A CD2 1 
ATOM   1609 N  N   . SER A 1 242 ? -11.931 -33.668 -35.985 1.00 28.63  ? 505  SER A N   1 
ATOM   1610 C  CA  . SER A 1 242 ? -11.077 -34.166 -34.887 1.00 27.73  ? 505  SER A CA  1 
ATOM   1611 C  C   . SER A 1 242 ? -11.926 -34.772 -33.780 1.00 27.52  ? 505  SER A C   1 
ATOM   1612 O  O   . SER A 1 242 ? -11.401 -35.579 -32.972 1.00 24.46  ? 505  SER A O   1 
ATOM   1613 C  CB  . SER A 1 242 ? -10.211 -33.041 -34.295 1.00 28.63  ? 505  SER A CB  1 
ATOM   1614 O  OG  . SER A 1 242 ? -9.397  -32.486 -35.290 1.00 29.73  ? 505  SER A OG  1 
ATOM   1615 N  N   . GLY A 1 243 ? -13.118 -34.223 -33.588 1.00 29.36  ? 506  GLY A N   1 
ATOM   1616 C  CA  . GLY A 1 243 ? -14.023 -34.578 -32.476 1.00 27.47  ? 506  GLY A CA  1 
ATOM   1617 C  C   . GLY A 1 243 ? -14.541 -36.000 -32.552 1.00 26.81  ? 506  GLY A C   1 
ATOM   1618 O  O   . GLY A 1 243 ? -14.432 -36.651 -33.586 1.00 25.73  ? 506  GLY A O   1 
ATOM   1619 N  N   . VAL A 1 244 ? -15.055 -36.473 -31.437 1.00 27.67  ? 507  VAL A N   1 
ATOM   1620 C  CA  . VAL A 1 244 ? -15.678 -37.814 -31.302 1.00 31.90  ? 507  VAL A CA  1 
ATOM   1621 C  C   . VAL A 1 244 ? -16.967 -37.682 -30.454 1.00 31.30  ? 507  VAL A C   1 
ATOM   1622 O  O   . VAL A 1 244 ? -17.399 -38.708 -29.866 1.00 29.89  ? 507  VAL A O   1 
ATOM   1623 C  CB  . VAL A 1 244 ? -14.690 -38.824 -30.650 1.00 31.50  ? 507  VAL A CB  1 
ATOM   1624 C  CG1 . VAL A 1 244 ? -13.452 -39.093 -31.483 1.00 28.58  ? 507  VAL A CG1 1 
ATOM   1625 C  CG2 . VAL A 1 244 ? -14.253 -38.361 -29.266 1.00 27.52  ? 507  VAL A CG2 1 
ATOM   1626 N  N   . GLU A 1 245 ? -17.555 -36.490 -30.296 1.00 33.15  ? 508  GLU A N   1 
ATOM   1627 C  CA  . GLU A 1 245 ? -18.738 -36.348 -29.389 1.00 34.18  ? 508  GLU A CA  1 
ATOM   1628 C  C   . GLU A 1 245 ? -19.878 -37.243 -29.914 1.00 30.96  ? 508  GLU A C   1 
ATOM   1629 O  O   . GLU A 1 245 ? -20.117 -37.226 -31.150 1.00 27.96  ? 508  GLU A O   1 
ATOM   1630 C  CB  . GLU A 1 245 ? -19.277 -34.928 -29.277 1.00 33.34  ? 508  GLU A CB  1 
ATOM   1631 C  CG  . GLU A 1 245 ? -20.374 -34.804 -28.222 1.00 37.65  ? 508  GLU A CG  1 
ATOM   1632 C  CD  . GLU A 1 245 ? -21.807 -35.131 -28.650 1.00 42.05  ? 508  GLU A CD  1 
ATOM   1633 O  OE1 . GLU A 1 245 ? -22.181 -34.847 -29.820 1.00 47.72  ? 508  GLU A OE1 1 
ATOM   1634 O  OE2 . GLU A 1 245 ? -22.565 -35.677 -27.810 1.00 51.94  ? 508  GLU A OE2 1 
ATOM   1635 N  N   . GLY A 1 246 ? -20.479 -38.063 -29.033 1.00 34.13  ? 509  GLY A N   1 
ATOM   1636 C  CA  . GLY A 1 246 ? -21.551 -39.016 -29.409 1.00 37.04  ? 509  GLY A CA  1 
ATOM   1637 C  C   . GLY A 1 246 ? -21.038 -40.251 -30.153 1.00 37.22  ? 509  GLY A C   1 
ATOM   1638 O  O   . GLY A 1 246 ? -21.881 -41.035 -30.621 1.00 32.09  ? 509  GLY A O   1 
ATOM   1639 N  N   . GLU A 1 247 ? -19.727 -40.469 -30.297 1.00 34.74  ? 510  GLU A N   1 
ATOM   1640 C  CA  . GLU A 1 247 ? -19.268 -41.565 -31.194 1.00 37.77  ? 510  GLU A CA  1 
ATOM   1641 C  C   . GLU A 1 247 ? -19.528 -42.909 -30.496 1.00 38.11  ? 510  GLU A C   1 
ATOM   1642 O  O   . GLU A 1 247 ? -20.006 -43.834 -31.207 1.00 46.28  ? 510  GLU A O   1 
ATOM   1643 C  CB  . GLU A 1 247 ? -17.840 -41.389 -31.714 1.00 33.45  ? 510  GLU A CB  1 
ATOM   1644 C  CG  . GLU A 1 247 ? -17.709 -40.154 -32.573 1.00 38.84  ? 510  GLU A CG  1 
ATOM   1645 C  CD  . GLU A 1 247 ? -18.600 -40.062 -33.810 1.00 46.36  ? 510  GLU A CD  1 
ATOM   1646 O  OE1 . GLU A 1 247 ? -18.703 -41.108 -34.493 1.00 39.39  ? 510  GLU A OE1 1 
ATOM   1647 O  OE2 . GLU A 1 247 ? -19.179 -38.893 -34.104 1.00 43.96  ? 510  GLU A OE2 1 
ATOM   1648 N  N   . GLY A 1 248 ? -19.264 -43.066 -29.203 1.00 34.60  ? 511  GLY A N   1 
ATOM   1649 C  CA  . GLY A 1 248 ? -19.469 -44.406 -28.579 1.00 33.72  ? 511  GLY A CA  1 
ATOM   1650 C  C   . GLY A 1 248 ? -18.183 -45.264 -28.582 1.00 35.44  ? 511  GLY A C   1 
ATOM   1651 O  O   . GLY A 1 248 ? -17.410 -45.264 -29.575 1.00 32.94  ? 511  GLY A O   1 
ATOM   1652 N  N   A LEU A 1 249 ? -17.992 -46.035 -27.515 0.25 32.37  ? 512  LEU A N   1 
ATOM   1653 N  N   B LEU A 1 249 ? -17.962 -46.005 -27.491 0.25 33.88  ? 512  LEU A N   1 
ATOM   1654 C  CA  A LEU A 1 249 ? -16.736 -46.760 -27.207 0.25 32.25  ? 512  LEU A CA  1 
ATOM   1655 C  CA  B LEU A 1 249 ? -16.723 -46.784 -27.219 0.25 34.63  ? 512  LEU A CA  1 
ATOM   1656 C  C   A LEU A 1 249 ? -16.488 -47.867 -28.238 0.25 32.29  ? 512  LEU A C   1 
ATOM   1657 C  C   B LEU A 1 249 ? -16.466 -47.789 -28.339 0.25 33.93  ? 512  LEU A C   1 
ATOM   1658 O  O   A LEU A 1 249 ? -15.327 -48.278 -28.389 0.25 34.05  ? 512  LEU A O   1 
ATOM   1659 O  O   B LEU A 1 249 ? -15.290 -48.068 -28.623 0.25 35.35  ? 512  LEU A O   1 
ATOM   1660 C  CB  A LEU A 1 249 ? -16.881 -47.317 -25.791 0.25 31.68  ? 512  LEU A CB  1 
ATOM   1661 C  CB  B LEU A 1 249 ? -16.870 -47.517 -25.885 0.25 35.81  ? 512  LEU A CB  1 
ATOM   1662 C  CG  A LEU A 1 249 ? -15.613 -47.863 -25.155 0.25 29.80  ? 512  LEU A CG  1 
ATOM   1663 C  CG  B LEU A 1 249 ? -16.019 -46.980 -24.741 0.25 35.52  ? 512  LEU A CG  1 
ATOM   1664 C  CD1 A LEU A 1 249 ? -14.544 -46.779 -25.036 0.25 30.45  ? 512  LEU A CD1 1 
ATOM   1665 C  CD1 B LEU A 1 249 ? -16.124 -47.899 -23.537 0.25 34.86  ? 512  LEU A CD1 1 
ATOM   1666 C  CD2 A LEU A 1 249 ? -15.947 -48.448 -23.797 0.25 29.24  ? 512  LEU A CD2 1 
ATOM   1667 C  CD2 B LEU A 1 249 ? -14.567 -46.819 -25.179 0.25 35.95  ? 512  LEU A CD2 1 
ATOM   1668 N  N   . HIS A 1 250 ? -17.536 -48.316 -28.930 0.50 32.11  ? 513  HIS A N   1 
ATOM   1669 C  CA  . HIS A 1 250 ? -17.477 -49.286 -30.056 0.50 31.08  ? 513  HIS A CA  1 
ATOM   1670 C  C   . HIS A 1 250 ? -17.056 -48.612 -31.372 0.50 30.65  ? 513  HIS A C   1 
ATOM   1671 O  O   . HIS A 1 250 ? -16.957 -49.340 -32.393 0.50 31.28  ? 513  HIS A O   1 
ATOM   1672 C  CB  . HIS A 1 250 ? -18.850 -49.939 -30.248 0.50 33.43  ? 513  HIS A CB  1 
ATOM   1673 C  CG  . HIS A 1 250 ? -19.927 -48.934 -30.455 0.50 33.18  ? 513  HIS A CG  1 
ATOM   1674 N  ND1 . HIS A 1 250 ? -20.299 -48.056 -29.461 0.50 33.27  ? 513  HIS A ND1 1 
ATOM   1675 C  CD2 . HIS A 1 250 ? -20.679 -48.638 -31.537 0.50 33.65  ? 513  HIS A CD2 1 
ATOM   1676 C  CE1 . HIS A 1 250 ? -21.247 -47.262 -29.917 0.50 34.26  ? 513  HIS A CE1 1 
ATOM   1677 N  NE2 . HIS A 1 250 ? -21.503 -47.605 -31.188 0.50 34.33  ? 513  HIS A NE2 1 
ATOM   1678 N  N   . LYS A 1 251 ? -16.920 -47.272 -31.384 1.00 30.69  ? 514  LYS A N   1 
ATOM   1679 C  CA  . LYS A 1 251 ? -16.450 -46.536 -32.594 1.00 29.58  ? 514  LYS A CA  1 
ATOM   1680 C  C   . LYS A 1 251 ? -15.026 -46.015 -32.406 1.00 29.29  ? 514  LYS A C   1 
ATOM   1681 O  O   . LYS A 1 251 ? -14.336 -45.874 -33.439 1.00 27.02  ? 514  LYS A O   1 
ATOM   1682 C  CB  . LYS A 1 251 ? -17.453 -45.443 -32.956 1.00 36.73  ? 514  LYS A CB  1 
ATOM   1683 C  CG  . LYS A 1 251 ? -18.879 -45.980 -33.114 1.00 42.79  ? 514  LYS A CG  1 
ATOM   1684 C  CD  . LYS A 1 251 ? -19.417 -45.923 -34.480 1.00 44.99  ? 514  LYS A CD  1 
ATOM   1685 C  CE  . LYS A 1 251 ? -20.149 -44.633 -34.736 1.00 50.00  ? 514  LYS A CE  1 
ATOM   1686 N  NZ  . LYS A 1 251 ? -20.827 -44.676 -36.050 1.00 55.37  ? 514  LYS A NZ  1 
ATOM   1687 N  N   . LEU A 1 252 ? -14.586 -45.735 -31.170 1.00 27.34  ? 515  LEU A N   1 
ATOM   1688 C  CA  . LEU A 1 252 ? -13.314 -44.994 -30.935 1.00 26.98  ? 515  LEU A CA  1 
ATOM   1689 C  C   . LEU A 1 252 ? -12.125 -45.765 -31.523 1.00 28.36  ? 515  LEU A C   1 
ATOM   1690 O  O   . LEU A 1 252 ? -11.245 -45.137 -32.168 1.00 28.39  ? 515  LEU A O   1 
ATOM   1691 C  CB  . LEU A 1 252 ? -13.170 -44.746 -29.443 1.00 25.48  ? 515  LEU A CB  1 
ATOM   1692 C  CG  . LEU A 1 252 ? -14.248 -43.865 -28.826 1.00 26.52  ? 515  LEU A CG  1 
ATOM   1693 C  CD1 . LEU A 1 252 ? -13.883 -43.502 -27.402 1.00 27.17  ? 515  LEU A CD1 1 
ATOM   1694 C  CD2 . LEU A 1 252 ? -14.477 -42.573 -29.603 1.00 24.39  ? 515  LEU A CD2 1 
ATOM   1695 N  N   . GLY A 1 253 ? -12.102 -47.093 -31.380 1.00 27.33  ? 516  GLY A N   1 
ATOM   1696 C  CA  . GLY A 1 253 ? -11.017 -47.911 -31.943 1.00 28.69  ? 516  GLY A CA  1 
ATOM   1697 C  C   . GLY A 1 253 ? -10.959 -47.847 -33.471 1.00 29.55  ? 516  GLY A C   1 
ATOM   1698 O  O   . GLY A 1 253 ? -9.858  -47.753 -34.039 1.00 29.65  ? 516  GLY A O   1 
ATOM   1699 N  N   . TYR A 1 254 ? -12.103 -47.912 -34.139 1.00 29.02  ? 517  TYR A N   1 
ATOM   1700 C  CA  . TYR A 1 254 ? -12.177 -47.796 -35.612 1.00 26.79  ? 517  TYR A CA  1 
ATOM   1701 C  C   . TYR A 1 254 ? -11.689 -46.413 -36.071 1.00 27.13  ? 517  TYR A C   1 
ATOM   1702 O  O   . TYR A 1 254 ? -10.992 -46.284 -37.091 1.00 27.32  ? 517  TYR A O   1 
ATOM   1703 C  CB  . TYR A 1 254 ? -13.612 -48.008 -36.073 1.00 29.30  ? 517  TYR A CB  1 
ATOM   1704 C  CG  . TYR A 1 254 ? -14.071 -49.438 -36.155 1.00 26.10  ? 517  TYR A CG  1 
ATOM   1705 C  CD1 . TYR A 1 254 ? -13.499 -50.339 -37.057 1.00 29.71  ? 517  TYR A CD1 1 
ATOM   1706 C  CD2 . TYR A 1 254 ? -15.066 -49.899 -35.301 1.00 27.92  ? 517  TYR A CD2 1 
ATOM   1707 C  CE1 . TYR A 1 254 ? -13.917 -51.668 -37.119 1.00 25.56  ? 517  TYR A CE1 1 
ATOM   1708 C  CE2 . TYR A 1 254 ? -15.512 -51.210 -35.358 1.00 27.35  ? 517  TYR A CE2 1 
ATOM   1709 C  CZ  . TYR A 1 254 ? -14.940 -52.091 -36.278 1.00 30.37  ? 517  TYR A CZ  1 
ATOM   1710 O  OH  . TYR A 1 254 ? -15.443 -53.369 -36.374 1.00 29.36  ? 517  TYR A OH  1 
ATOM   1711 N  N   . ILE A 1 255 ? -12.029 -45.383 -35.311 1.00 27.84  ? 518  ILE A N   1 
ATOM   1712 C  CA  . ILE A 1 255 ? -11.583 -44.002 -35.569 1.00 29.48  ? 518  ILE A CA  1 
ATOM   1713 C  C   . ILE A 1 255 ? -10.050 -43.911 -35.453 1.00 31.21  ? 518  ILE A C   1 
ATOM   1714 O  O   . ILE A 1 255 ? -9.449  -43.389 -36.441 1.00 29.14  ? 518  ILE A O   1 
ATOM   1715 C  CB  . ILE A 1 255 ? -12.350 -43.002 -34.678 1.00 29.89  ? 518  ILE A CB  1 
ATOM   1716 C  CG1 . ILE A 1 255 ? -13.804 -42.879 -35.169 1.00 27.89  ? 518  ILE A CG1 1 
ATOM   1717 C  CG2 . ILE A 1 255 ? -11.617 -41.665 -34.681 1.00 28.57  ? 518  ILE A CG2 1 
ATOM   1718 C  CD1 . ILE A 1 255 ? -14.758 -42.166 -34.210 1.00 29.41  ? 518  ILE A CD1 1 
ATOM   1719 N  N   . LEU A 1 256 ? -9.433  -44.441 -34.383 1.00 28.27  ? 519  LEU A N   1 
ATOM   1720 C  CA  . LEU A 1 256 ? -7.950  -44.449 -34.230 1.00 30.47  ? 519  LEU A CA  1 
ATOM   1721 C  C   . LEU A 1 256 ? -7.288  -45.220 -35.381 1.00 33.66  ? 519  LEU A C   1 
ATOM   1722 O  O   . LEU A 1 256 ? -6.217  -44.777 -35.870 1.00 33.39  ? 519  LEU A O   1 
ATOM   1723 C  CB  . LEU A 1 256 ? -7.542  -45.081 -32.898 1.00 32.16  ? 519  LEU A CB  1 
ATOM   1724 C  CG  . LEU A 1 256 ? -7.885  -44.296 -31.631 1.00 29.93  ? 519  LEU A CG  1 
ATOM   1725 C  CD1 . LEU A 1 256 ? -7.184  -44.913 -30.430 1.00 34.00  ? 519  LEU A CD1 1 
ATOM   1726 C  CD2 . LEU A 1 256 ? -7.502  -42.830 -31.736 1.00 32.82  ? 519  LEU A CD2 1 
ATOM   1727 N  N   . ARG A 1 257 ? -7.845  -46.375 -35.762 1.00 34.30  ? 520  ARG A N   1 
ATOM   1728 C  CA  . ARG A 1 257 ? -7.306  -47.163 -36.899 1.00 34.13  ? 520  ARG A CA  1 
ATOM   1729 C  C   . ARG A 1 257 ? -7.423  -46.339 -38.189 1.00 33.90  ? 520  ARG A C   1 
ATOM   1730 O  O   . ARG A 1 257 ? -6.495  -46.441 -39.035 1.00 34.51  ? 520  ARG A O   1 
ATOM   1731 C  CB  . ARG A 1 257 ? -7.984  -48.523 -37.004 1.00 32.41  ? 520  ARG A CB  1 
ATOM   1732 C  CG  . ARG A 1 257 ? -7.437  -49.391 -38.136 1.00 34.11  ? 520  ARG A CG  1 
ATOM   1733 C  CD  . ARG A 1 257 ? -8.170  -50.715 -38.188 1.00 33.99  ? 520  ARG A CD  1 
ATOM   1734 N  NE  . ARG A 1 257 ? -9.457  -50.545 -38.870 1.00 38.29  ? 520  ARG A NE  1 
ATOM   1735 C  CZ  . ARG A 1 257 ? -10.238 -51.530 -39.328 1.00 33.98  ? 520  ARG A CZ  1 
ATOM   1736 N  NH1 . ARG A 1 257 ? -9.934  -52.794 -39.138 1.00 35.83  ? 520  ARG A NH1 1 
ATOM   1737 N  NH2 . ARG A 1 257 ? -11.356 -51.238 -39.944 1.00 37.25  ? 520  ARG A NH2 1 
ATOM   1738 N  N   . ASP A 1 258 ? -8.485  -45.549 -38.355 1.00 32.02  ? 521  ASP A N   1 
ATOM   1739 C  CA  . ASP A 1 258 ? -8.608  -44.684 -39.569 1.00 33.32  ? 521  ASP A CA  1 
ATOM   1740 C  C   . ASP A 1 258 ? -7.487  -43.614 -39.551 1.00 32.42  ? 521  ASP A C   1 
ATOM   1741 O  O   . ASP A 1 258 ? -6.872  -43.383 -40.578 1.00 31.56  ? 521  ASP A O   1 
ATOM   1742 C  CB  . ASP A 1 258 ? -10.027 -44.118 -39.761 1.00 35.10  ? 521  ASP A CB  1 
ATOM   1743 C  CG  . ASP A 1 258 ? -11.015 -45.012 -40.531 1.00 35.94  ? 521  ASP A CG  1 
ATOM   1744 O  OD1 . ASP A 1 258 ? -10.619 -46.058 -41.058 1.00 32.71  ? 521  ASP A OD1 1 
ATOM   1745 O  OD2 . ASP A 1 258 ? -12.201 -44.670 -40.551 1.00 35.77  ? 521  ASP A OD2 1 
ATOM   1746 N  N   . VAL A 1 259 ? -7.245  -42.960 -38.424 1.00 29.14  ? 522  VAL A N   1 
ATOM   1747 C  CA  . VAL A 1 259 ? -6.142  -41.986 -38.267 1.00 31.91  ? 522  VAL A CA  1 
ATOM   1748 C  C   . VAL A 1 259 ? -4.815  -42.664 -38.645 1.00 34.60  ? 522  VAL A C   1 
ATOM   1749 O  O   . VAL A 1 259 ? -4.045  -42.064 -39.387 1.00 38.18  ? 522  VAL A O   1 
ATOM   1750 C  CB  . VAL A 1 259 ? -6.079  -41.498 -36.823 1.00 31.79  ? 522  VAL A CB  1 
ATOM   1751 C  CG1 . VAL A 1 259 ? -4.782  -40.727 -36.607 1.00 30.35  ? 522  VAL A CG1 1 
ATOM   1752 C  CG2 . VAL A 1 259 ? -7.311  -40.679 -36.485 1.00 33.39  ? 522  VAL A CG2 1 
ATOM   1753 N  N   . SER A 1 260 ? -4.592  -43.893 -38.192 1.00 32.24  ? 523  SER A N   1 
ATOM   1754 C  CA  . SER A 1 260 ? -3.347  -44.674 -38.418 1.00 36.09  ? 523  SER A CA  1 
ATOM   1755 C  C   . SER A 1 260 ? -3.079  -44.878 -39.920 1.00 36.28  ? 523  SER A C   1 
ATOM   1756 O  O   . SER A 1 260 ? -1.931  -45.018 -40.277 1.00 33.97  ? 523  SER A O   1 
ATOM   1757 C  CB  . SER A 1 260 ? -3.395  -45.997 -37.694 1.00 35.64  ? 523  SER A CB  1 
ATOM   1758 O  OG  . SER A 1 260 ? -3.934  -47.024 -38.525 1.00 35.20  ? 523  SER A OG  1 
ATOM   1759 N  N   . LYS A 1 261 ? -4.105  -44.851 -40.753 1.00 34.86  ? 524  LYS A N   1 
ATOM   1760 C  CA  . LYS A 1 261 ? -4.028  -45.138 -42.204 1.00 38.71  ? 524  LYS A CA  1 
ATOM   1761 C  C   . LYS A 1 261 ? -3.426  -43.953 -42.956 1.00 40.46  ? 524  LYS A C   1 
ATOM   1762 O  O   . LYS A 1 261 ? -3.053  -44.157 -44.130 1.00 40.06  ? 524  LYS A O   1 
ATOM   1763 C  CB  . LYS A 1 261 ? -5.424  -45.436 -42.771 1.00 43.28  ? 524  LYS A CB  1 
ATOM   1764 C  CG  . LYS A 1 261 ? -5.821  -46.883 -42.556 1.00 53.07  ? 524  LYS A CG  1 
ATOM   1765 C  CD  . LYS A 1 261 ? -7.271  -47.215 -42.816 1.00 60.55  ? 524  LYS A CD  1 
ATOM   1766 C  CE  . LYS A 1 261 ? -7.471  -48.695 -42.581 1.00 68.51  ? 524  LYS A CE  1 
ATOM   1767 N  NZ  . LYS A 1 261 ? -8.781  -49.138 -43.096 1.00 87.84  ? 524  LYS A NZ  1 
ATOM   1768 N  N   . LYS A 1 262 ? -3.440  -42.762 -42.351 1.00 40.87  ? 525  LYS A N   1 
ATOM   1769 C  CA  . LYS A 1 262 ? -2.845  -41.524 -42.914 1.00 41.54  ? 525  LYS A CA  1 
ATOM   1770 C  C   . LYS A 1 262 ? -1.344  -41.728 -42.983 1.00 41.75  ? 525  LYS A C   1 
ATOM   1771 O  O   . LYS A 1 262 ? -0.787  -42.269 -42.002 1.00 43.84  ? 525  LYS A O   1 
ATOM   1772 C  CB  . LYS A 1 262 ? -3.176  -40.301 -42.051 1.00 43.87  ? 525  LYS A CB  1 
ATOM   1773 C  CG  . LYS A 1 262 ? -4.674  -40.026 -41.952 1.00 46.26  ? 525  LYS A CG  1 
ATOM   1774 C  CD  . LYS A 1 262 ? -5.065  -38.581 -41.956 1.00 47.25  ? 525  LYS A CD  1 
ATOM   1775 C  CE  . LYS A 1 262 ? -6.491  -38.358 -42.402 1.00 54.98  ? 525  LYS A CE  1 
ATOM   1776 N  NZ  . LYS A 1 262 ? -6.562  -37.299 -43.446 1.00 58.28  ? 525  LYS A NZ  1 
ATOM   1777 N  N   . GLU A 1 263 ? -0.720  -41.291 -44.074 1.00 41.10  ? 526  GLU A N   1 
ATOM   1778 C  CA  . GLU A 1 263 ? 0.757   -41.168 -44.139 1.00 39.16  ? 526  GLU A CA  1 
ATOM   1779 C  C   . GLU A 1 263 ? 1.180   -40.181 -43.042 1.00 37.31  ? 526  GLU A C   1 
ATOM   1780 O  O   . GLU A 1 263 ? 0.505   -39.163 -42.917 1.00 40.55  ? 526  GLU A O   1 
ATOM   1781 C  CB  . GLU A 1 263 ? 1.186   -40.677 -45.518 1.00 50.37  ? 526  GLU A CB  1 
ATOM   1782 C  CG  . GLU A 1 263 ? 0.883   -41.656 -46.658 1.00 57.75  ? 526  GLU A CG  1 
ATOM   1783 C  CD  . GLU A 1 263 ? 1.684   -42.950 -46.642 1.00 61.60  ? 526  GLU A CD  1 
ATOM   1784 O  OE1 . GLU A 1 263 ? 2.840   -42.939 -46.153 1.00 65.72  ? 526  GLU A OE1 1 
ATOM   1785 O  OE2 . GLU A 1 263 ? 1.150   -43.973 -47.107 1.00 69.58  ? 526  GLU A OE2 1 
ATOM   1786 N  N   . GLY A 1 264 ? 2.211   -40.490 -42.259 1.00 33.54  ? 527  GLY A N   1 
ATOM   1787 C  CA  . GLY A 1 264 ? 2.818   -39.536 -41.312 1.00 37.43  ? 527  GLY A CA  1 
ATOM   1788 C  C   . GLY A 1 264 ? 3.740   -40.230 -40.337 1.00 36.85  ? 527  GLY A C   1 
ATOM   1789 O  O   . GLY A 1 264 ? 4.184   -41.331 -40.621 1.00 39.00  ? 527  GLY A O   1 
ATOM   1790 N  N   . GLY A 1 265 ? 4.003   -39.622 -39.188 1.00 38.75  ? 528  GLY A N   1 
ATOM   1791 C  CA  . GLY A 1 265 ? 4.932   -40.208 -38.205 1.00 38.30  ? 528  GLY A CA  1 
ATOM   1792 C  C   . GLY A 1 265 ? 4.209   -40.994 -37.109 1.00 41.14  ? 528  GLY A C   1 
ATOM   1793 O  O   . GLY A 1 265 ? 3.166   -41.573 -37.377 1.00 41.50  ? 528  GLY A O   1 
ATOM   1794 N  N   . ALA A 1 266 ? 4.761   -41.015 -35.904 1.00 32.48  ? 529  ALA A N   1 
ATOM   1795 C  CA  . ALA A 1 266 ? 4.218   -41.754 -34.761 1.00 34.66  ? 529  ALA A CA  1 
ATOM   1796 C  C   . ALA A 1 266 ? 2.856   -41.156 -34.416 1.00 33.97  ? 529  ALA A C   1 
ATOM   1797 O  O   . ALA A 1 266 ? 2.541   -40.076 -34.930 1.00 31.70  ? 529  ALA A O   1 
ATOM   1798 C  CB  . ALA A 1 266 ? 5.188   -41.686 -33.596 1.00 33.54  ? 529  ALA A CB  1 
ATOM   1799 N  N   . MET A 1 267 ? 2.070   -41.866 -33.609 1.00 31.33  ? 530  MET A N   1 
ATOM   1800 C  CA  . MET A 1 267 ? 0.834   -41.356 -32.990 1.00 31.07  ? 530  MET A CA  1 
ATOM   1801 C  C   . MET A 1 267 ? 1.236   -40.819 -31.612 1.00 29.18  ? 530  MET A C   1 
ATOM   1802 O  O   . MET A 1 267 ? 1.853   -41.549 -30.845 1.00 34.07  ? 530  MET A O   1 
ATOM   1803 C  CB  . MET A 1 267 ? -0.269  -42.437 -32.939 1.00 34.24  ? 530  MET A CB  1 
ATOM   1804 C  CG  . MET A 1 267 ? -0.611  -42.949 -34.359 1.00 38.67  ? 530  MET A CG  1 
ATOM   1805 S  SD  . MET A 1 267 ? -2.040  -44.062 -34.644 1.00 40.65  ? 530  MET A SD  1 
ATOM   1806 C  CE  . MET A 1 267 ? -3.207  -43.478 -33.440 1.00 42.37  ? 530  MET A CE  1 
ATOM   1807 N  N   . TYR A 1 268 ? 0.923   -39.555 -31.329 1.00 28.03  ? 531  TYR A N   1 
ATOM   1808 C  CA  . TYR A 1 268 ? 1.233   -38.874 -30.055 1.00 25.00  ? 531  TYR A CA  1 
ATOM   1809 C  C   . TYR A 1 268 ? -0.033  -38.741 -29.236 1.00 26.68  ? 531  TYR A C   1 
ATOM   1810 O  O   . TYR A 1 268 ? -1.135  -38.384 -29.758 1.00 29.70  ? 531  TYR A O   1 
ATOM   1811 C  CB  . TYR A 1 268 ? 1.904   -37.529 -30.293 1.00 26.02  ? 531  TYR A CB  1 
ATOM   1812 C  CG  . TYR A 1 268 ? 3.220   -37.666 -31.011 1.00 29.50  ? 531  TYR A CG  1 
ATOM   1813 C  CD1 . TYR A 1 268 ? 3.267   -37.891 -32.381 1.00 29.03  ? 531  TYR A CD1 1 
ATOM   1814 C  CD2 . TYR A 1 268 ? 4.407   -37.730 -30.312 1.00 29.97  ? 531  TYR A CD2 1 
ATOM   1815 C  CE1 . TYR A 1 268 ? 4.478   -38.078 -33.029 1.00 32.34  ? 531  TYR A CE1 1 
ATOM   1816 C  CE2 . TYR A 1 268 ? 5.620   -37.930 -30.950 1.00 30.77  ? 531  TYR A CE2 1 
ATOM   1817 C  CZ  . TYR A 1 268 ? 5.668   -38.101 -32.318 1.00 34.24  ? 531  TYR A CZ  1 
ATOM   1818 O  OH  . TYR A 1 268 ? 6.871   -38.342 -32.961 1.00 30.02  ? 531  TYR A OH  1 
ATOM   1819 N  N   . ALA A 1 269 ? 0.115   -39.025 -27.952 1.00 28.15  ? 532  ALA A N   1 
ATOM   1820 C  CA  . ALA A 1 269 ? -0.986  -38.969 -26.989 1.00 29.16  ? 532  ALA A CA  1 
ATOM   1821 C  C   . ALA A 1 269 ? -0.446  -38.406 -25.694 1.00 31.82  ? 532  ALA A C   1 
ATOM   1822 O  O   . ALA A 1 269 ? -0.439  -39.122 -24.700 1.00 33.35  ? 532  ALA A O   1 
ATOM   1823 C  CB  . ALA A 1 269 ? -1.616  -40.336 -26.820 1.00 30.07  ? 532  ALA A CB  1 
ATOM   1824 N  N   . ASP A 1 270 ? -0.108  -37.129 -25.706 1.00 28.50  ? 533  ASP A N   1 
ATOM   1825 C  CA  . ASP A 1 270 ? 0.429   -36.434 -24.519 1.00 29.89  ? 533  ASP A CA  1 
ATOM   1826 C  C   . ASP A 1 270 ? -0.747  -35.934 -23.689 1.00 33.47  ? 533  ASP A C   1 
ATOM   1827 O  O   . ASP A 1 270 ? -1.528  -35.144 -24.176 1.00 32.26  ? 533  ASP A O   1 
ATOM   1828 C  CB  . ASP A 1 270 ? 1.342   -35.290 -24.974 1.00 32.43  ? 533  ASP A CB  1 
ATOM   1829 C  CG  . ASP A 1 270 ? 2.571   -35.759 -25.725 1.00 32.24  ? 533  ASP A CG  1 
ATOM   1830 O  OD1 . ASP A 1 270 ? 2.922   -36.942 -25.530 1.00 36.73  ? 533  ASP A OD1 1 
ATOM   1831 O  OD2 . ASP A 1 270 ? 3.156   -34.961 -26.506 1.00 31.29  ? 533  ASP A OD2 1 
ATOM   1832 N  N   . ASP A 1 271 ? -0.876  -36.412 -22.477 1.00 34.16  ? 534  ASP A N   1 
ATOM   1833 C  CA  . ASP A 1 271 ? -1.806  -35.833 -21.487 1.00 36.85  ? 534  ASP A CA  1 
ATOM   1834 C  C   . ASP A 1 271 ? -1.245  -34.519 -20.961 1.00 36.48  ? 534  ASP A C   1 
ATOM   1835 O  O   . ASP A 1 271 ? -0.033  -34.409 -20.761 1.00 34.07  ? 534  ASP A O   1 
ATOM   1836 C  CB  . ASP A 1 271 ? -1.979  -36.738 -20.264 1.00 38.13  ? 534  ASP A CB  1 
ATOM   1837 C  CG  . ASP A 1 271 ? -2.958  -37.855 -20.516 1.00 41.21  ? 534  ASP A CG  1 
ATOM   1838 O  OD1 . ASP A 1 271 ? -3.582  -37.836 -21.593 1.00 42.83  ? 534  ASP A OD1 1 
ATOM   1839 O  OD2 . ASP A 1 271 ? -3.133  -38.699 -19.627 1.00 50.53  ? 534  ASP A OD2 1 
ATOM   1840 N  N   . THR A 1 272 ? -2.127  -33.545 -20.727 0.35 36.39  ? 535  THR A N   1 
ATOM   1841 C  CA  . THR A 1 272 ? -1.798  -32.245 -20.089 0.35 36.18  ? 535  THR A CA  1 
ATOM   1842 C  C   . THR A 1 272 ? -1.937  -32.410 -18.577 0.35 36.72  ? 535  THR A C   1 
ATOM   1843 O  O   . THR A 1 272 ? -2.909  -33.047 -18.147 0.35 38.79  ? 535  THR A O   1 
ATOM   1844 C  CB  . THR A 1 272 ? -2.685  -31.120 -20.635 0.35 36.33  ? 535  THR A CB  1 
ATOM   1845 O  OG1 . THR A 1 272 ? -2.508  -31.085 -22.051 0.35 37.72  ? 535  THR A OG1 1 
ATOM   1846 C  CG2 . THR A 1 272 ? -2.359  -29.762 -20.053 0.35 36.67  ? 535  THR A CG2 1 
ATOM   1847 N  N   . ALA A 1 273 ? -0.989  -31.867 -17.811 0.35 39.05  ? 536  ALA A N   1 
ATOM   1848 C  CA  . ALA A 1 273 ? -1.049  -31.803 -16.333 0.35 40.91  ? 536  ALA A CA  1 
ATOM   1849 C  C   . ALA A 1 273 ? -2.126  -30.787 -15.932 0.35 40.93  ? 536  ALA A C   1 
ATOM   1850 O  O   . ALA A 1 273 ? -1.931  -29.594 -16.211 0.35 43.75  ? 536  ALA A O   1 
ATOM   1851 C  CB  . ALA A 1 273 ? 0.307   -31.436 -15.775 0.35 41.06  ? 536  ALA A CB  1 
ATOM   1852 N  N   . GLY A 1 274 ? -3.237  -31.260 -15.359 1.00 43.18  ? 537  GLY A N   1 
ATOM   1853 C  CA  . GLY A 1 274 ? -4.333  -30.403 -14.842 1.00 41.13  ? 537  GLY A CA  1 
ATOM   1854 C  C   . GLY A 1 274 ? -4.920  -29.437 -15.869 1.00 40.76  ? 537  GLY A C   1 
ATOM   1855 O  O   . GLY A 1 274 ? -4.931  -28.215 -15.596 1.00 35.76  ? 537  GLY A O   1 
ATOM   1856 N  N   . TRP A 1 275 ? -5.438  -29.946 -16.986 1.00 37.42  ? 538  TRP A N   1 
ATOM   1857 C  CA  . TRP A 1 275 ? -5.884  -29.112 -18.131 1.00 34.53  ? 538  TRP A CA  1 
ATOM   1858 C  C   . TRP A 1 275 ? -6.793  -27.955 -17.699 1.00 35.67  ? 538  TRP A C   1 
ATOM   1859 O  O   . TRP A 1 275 ? -6.564  -26.848 -18.217 1.00 36.37  ? 538  TRP A O   1 
ATOM   1860 C  CB  . TRP A 1 275 ? -6.597  -29.958 -19.167 1.00 31.39  ? 538  TRP A CB  1 
ATOM   1861 C  CG  . TRP A 1 275 ? -7.205  -29.109 -20.231 1.00 30.04  ? 538  TRP A CG  1 
ATOM   1862 C  CD1 . TRP A 1 275 ? -8.401  -28.471 -20.137 1.00 30.66  ? 538  TRP A CD1 1 
ATOM   1863 C  CD2 . TRP A 1 275 ? -6.697  -28.825 -21.551 1.00 29.28  ? 538  TRP A CD2 1 
ATOM   1864 N  NE1 . TRP A 1 275 ? -8.692  -27.864 -21.324 1.00 33.66  ? 538  TRP A NE1 1 
ATOM   1865 C  CE2 . TRP A 1 275 ? -7.647  -28.000 -22.189 1.00 30.16  ? 538  TRP A CE2 1 
ATOM   1866 C  CE3 . TRP A 1 275 ? -5.550  -29.174 -22.266 1.00 28.60  ? 538  TRP A CE3 1 
ATOM   1867 C  CZ2 . TRP A 1 275 ? -7.490  -27.511 -23.490 1.00 32.94  ? 538  TRP A CZ2 1 
ATOM   1868 C  CZ3 . TRP A 1 275 ? -5.386  -28.686 -23.551 1.00 32.19  ? 538  TRP A CZ3 1 
ATOM   1869 C  CH2 . TRP A 1 275 ? -6.366  -27.910 -24.175 1.00 32.38  ? 538  TRP A CH2 1 
ATOM   1870 N  N   . ASP A 1 276 ? -7.759  -28.183 -16.803 1.00 37.95  ? 539  ASP A N   1 
ATOM   1871 C  CA  . ASP A 1 276 ? -8.765  -27.154 -16.372 1.00 43.41  ? 539  ASP A CA  1 
ATOM   1872 C  C   . ASP A 1 276 ? -8.074  -25.964 -15.678 1.00 46.27  ? 539  ASP A C   1 
ATOM   1873 O  O   . ASP A 1 276 ? -8.489  -24.791 -15.920 1.00 42.06  ? 539  ASP A O   1 
ATOM   1874 C  CB  . ASP A 1 276 ? -9.859  -27.756 -15.496 1.00 41.59  ? 539  ASP A CB  1 
ATOM   1875 C  CG  . ASP A 1 276 ? -10.889 -28.535 -16.314 1.00 45.12  ? 539  ASP A CG  1 
ATOM   1876 O  OD1 . ASP A 1 276 ? -10.787 -28.547 -17.568 1.00 46.00  ? 539  ASP A OD1 1 
ATOM   1877 O  OD2 . ASP A 1 276 ? -11.776 -29.124 -15.712 1.00 44.59  ? 539  ASP A OD2 1 
ATOM   1878 N  N   . THR A 1 277 ? -7.002  -26.220 -14.925 1.00 42.11  ? 540  THR A N   1 
ATOM   1879 C  CA  . THR A 1 277 ? -6.227  -25.165 -14.211 1.00 40.98  ? 540  THR A CA  1 
ATOM   1880 C  C   . THR A 1 277 ? -5.302  -24.360 -15.141 1.00 39.61  ? 540  THR A C   1 
ATOM   1881 O  O   . THR A 1 277 ? -4.827  -23.320 -14.710 1.00 45.66  ? 540  THR A O   1 
ATOM   1882 C  CB  . THR A 1 277 ? -5.437  -25.760 -13.037 1.00 41.28  ? 540  THR A CB  1 
ATOM   1883 O  OG1 . THR A 1 277 ? -4.462  -26.667 -13.541 1.00 48.26  ? 540  THR A OG1 1 
ATOM   1884 C  CG2 . THR A 1 277 ? -6.328  -26.491 -12.061 1.00 42.46  ? 540  THR A CG2 1 
ATOM   1885 N  N   . ARG A 1 278 ? -5.071  -24.851 -16.365 0.35 40.76  ? 541  ARG A N   1 
ATOM   1886 C  CA  . ARG A 1 278 ? -4.127  -24.274 -17.362 0.35 40.90  ? 541  ARG A CA  1 
ATOM   1887 C  C   . ARG A 1 278 ? -4.891  -23.486 -18.432 0.35 40.44  ? 541  ARG A C   1 
ATOM   1888 O  O   . ARG A 1 278 ? -4.261  -23.120 -19.445 0.35 40.24  ? 541  ARG A O   1 
ATOM   1889 C  CB  . ARG A 1 278 ? -3.327  -25.381 -18.058 0.35 43.00  ? 541  ARG A CB  1 
ATOM   1890 C  CG  . ARG A 1 278 ? -2.705  -26.403 -17.120 0.35 46.16  ? 541  ARG A CG  1 
ATOM   1891 C  CD  . ARG A 1 278 ? -1.405  -25.938 -16.502 0.35 49.14  ? 541  ARG A CD  1 
ATOM   1892 N  NE  . ARG A 1 278 ? -0.811  -26.965 -15.652 0.35 52.48  ? 541  ARG A NE  1 
ATOM   1893 C  CZ  . ARG A 1 278 ? 0.378   -26.865 -15.062 0.35 53.34  ? 541  ARG A CZ  1 
ATOM   1894 N  NH1 . ARG A 1 278 ? 1.121   -25.783 -15.235 0.35 54.21  ? 541  ARG A NH1 1 
ATOM   1895 N  NH2 . ARG A 1 278 ? 0.819   -27.846 -14.295 0.35 55.97  ? 541  ARG A NH2 1 
ATOM   1896 N  N   . ILE A 1 279 ? -6.199  -23.281 -18.250 0.35 40.62  ? 542  ILE A N   1 
ATOM   1897 C  CA  . ILE A 1 279 ? -7.046  -22.468 -19.172 0.35 41.47  ? 542  ILE A CA  1 
ATOM   1898 C  C   . ILE A 1 279 ? -6.812  -20.988 -18.841 0.35 40.65  ? 542  ILE A C   1 
ATOM   1899 O  O   . ILE A 1 279 ? -7.147  -20.572 -17.717 0.35 39.42  ? 542  ILE A O   1 
ATOM   1900 C  CB  . ILE A 1 279 ? -8.529  -22.886 -19.068 0.35 41.92  ? 542  ILE A CB  1 
ATOM   1901 C  CG1 . ILE A 1 279 ? -8.763  -24.258 -19.704 0.35 41.88  ? 542  ILE A CG1 1 
ATOM   1902 C  CG2 . ILE A 1 279 ? -9.451  -21.833 -19.670 0.35 41.67  ? 542  ILE A CG2 1 
ATOM   1903 C  CD1 . ILE A 1 279 ? -8.684  -24.255 -21.213 0.35 42.06  ? 542  ILE A CD1 1 
ATOM   1904 N  N   . THR A 1 280 ? -6.238  -20.237 -19.786 1.00 41.28  ? 543  THR A N   1 
ATOM   1905 C  CA  . THR A 1 280 ? -5.839  -18.822 -19.586 1.00 44.05  ? 543  THR A CA  1 
ATOM   1906 C  C   . THR A 1 280 ? -7.035  -17.919 -19.875 1.00 47.50  ? 543  THR A C   1 
ATOM   1907 O  O   . THR A 1 280 ? -7.966  -18.355 -20.603 1.00 45.71  ? 543  THR A O   1 
ATOM   1908 C  CB  . THR A 1 280 ? -4.663  -18.494 -20.498 1.00 38.69  ? 543  THR A CB  1 
ATOM   1909 O  OG1 . THR A 1 280 ? -5.127  -18.713 -21.828 1.00 37.35  ? 543  THR A OG1 1 
ATOM   1910 C  CG2 . THR A 1 280 ? -3.479  -19.386 -20.226 1.00 44.81  ? 543  THR A CG2 1 
ATOM   1911 N  N   . LEU A 1 281 ? -7.010  -16.700 -19.362 1.00 49.16  ? 544  LEU A N   1 
ATOM   1912 C  CA  . LEU A 1 281 ? -8.000  -15.675 -19.780 1.00 48.13  ? 544  LEU A CA  1 
ATOM   1913 C  C   . LEU A 1 281 ? -7.935  -15.519 -21.307 1.00 43.52  ? 544  LEU A C   1 
ATOM   1914 O  O   . LEU A 1 281 ? -8.957  -15.277 -21.886 1.00 43.83  ? 544  LEU A O   1 
ATOM   1915 C  CB  . LEU A 1 281 ? -7.707  -14.343 -19.078 1.00 54.94  ? 544  LEU A CB  1 
ATOM   1916 C  CG  . LEU A 1 281 ? -8.668  -13.210 -19.439 1.00 60.98  ? 544  LEU A CG  1 
ATOM   1917 C  CD1 . LEU A 1 281 ? -10.139 -13.660 -19.346 1.00 52.19  ? 544  LEU A CD1 1 
ATOM   1918 C  CD2 . LEU A 1 281 ? -8.409  -11.990 -18.564 1.00 65.17  ? 544  LEU A CD2 1 
ATOM   1919 N  N   . GLU A 1 282 ? -6.781  -15.703 -21.951 1.00 46.03  ? 545  GLU A N   1 
ATOM   1920 C  CA  . GLU A 1 282 ? -6.675  -15.608 -23.437 1.00 44.00  ? 545  GLU A CA  1 
ATOM   1921 C  C   . GLU A 1 282 ? -7.465  -16.747 -24.111 1.00 44.60  ? 545  GLU A C   1 
ATOM   1922 O  O   . GLU A 1 282 ? -8.172  -16.522 -25.156 1.00 41.25  ? 545  GLU A O   1 
ATOM   1923 C  CB  . GLU A 1 282 ? -5.210  -15.644 -23.834 1.00 50.23  ? 545  GLU A CB  1 
ATOM   1924 C  CG  . GLU A 1 282 ? -4.965  -14.982 -25.165 1.00 61.98  ? 545  GLU A CG  1 
ATOM   1925 C  CD  . GLU A 1 282 ? -5.055  -13.465 -25.124 1.00 62.65  ? 545  GLU A CD  1 
ATOM   1926 O  OE1 . GLU A 1 282 ? -4.861  -12.893 -24.022 1.00 60.96  ? 545  GLU A OE1 1 
ATOM   1927 O  OE2 . GLU A 1 282 ? -5.340  -12.875 -26.188 1.00 61.67  ? 545  GLU A OE2 1 
ATOM   1928 N  N   . ASP A 1 283 ? -7.397  -17.938 -23.528 1.00 38.71  ? 546  ASP A N   1 
ATOM   1929 C  CA  . ASP A 1 283 ? -8.239  -19.092 -23.942 1.00 38.31  ? 546  ASP A CA  1 
ATOM   1930 C  C   . ASP A 1 283 ? -9.734  -18.722 -23.787 1.00 37.94  ? 546  ASP A C   1 
ATOM   1931 O  O   . ASP A 1 283 ? -10.517 -18.917 -24.761 1.00 38.04  ? 546  ASP A O   1 
ATOM   1932 C  CB  . ASP A 1 283 ? -7.893  -20.358 -23.140 1.00 35.92  ? 546  ASP A CB  1 
ATOM   1933 C  CG  . ASP A 1 283 ? -6.525  -20.974 -23.394 1.00 31.79  ? 546  ASP A CG  1 
ATOM   1934 O  OD1 . ASP A 1 283 ? -6.003  -20.862 -24.523 1.00 33.02  ? 546  ASP A OD1 1 
ATOM   1935 O  OD2 . ASP A 1 283 ? -6.018  -21.595 -22.458 1.00 32.79  ? 546  ASP A OD2 1 
ATOM   1936 N  N   . LEU A 1 284 ? -10.166 -18.262 -22.605 1.00 36.74  ? 547  LEU A N   1 
ATOM   1937 C  CA  . LEU A 1 284 ? -11.594 -17.866 -22.368 1.00 38.99  ? 547  LEU A CA  1 
ATOM   1938 C  C   . LEU A 1 284 ? -12.093 -16.859 -23.440 1.00 40.74  ? 547  LEU A C   1 
ATOM   1939 O  O   . LEU A 1 284 ? -13.227 -16.995 -23.919 1.00 41.71  ? 547  LEU A O   1 
ATOM   1940 C  CB  . LEU A 1 284 ? -11.721 -17.338 -20.936 1.00 41.56  ? 547  LEU A CB  1 
ATOM   1941 C  CG  . LEU A 1 284 ? -11.480 -18.395 -19.856 1.00 43.13  ? 547  LEU A CG  1 
ATOM   1942 C  CD1 . LEU A 1 284 ? -11.467 -17.797 -18.471 1.00 47.49  ? 547  LEU A CD1 1 
ATOM   1943 C  CD2 . LEU A 1 284 ? -12.537 -19.487 -19.900 1.00 43.84  ? 547  LEU A CD2 1 
ATOM   1944 N  N   . LYS A 1 285 ? -11.236 -15.897 -23.808 0.35 40.97  ? 548  LYS A N   1 
ATOM   1945 C  CA  . LYS A 1 285 ? -11.517 -14.837 -24.815 0.35 41.10  ? 548  LYS A CA  1 
ATOM   1946 C  C   . LYS A 1 285 ? -11.671 -15.460 -26.210 0.35 40.26  ? 548  LYS A C   1 
ATOM   1947 O  O   . LYS A 1 285 ? -12.613 -15.065 -26.921 0.35 41.54  ? 548  LYS A O   1 
ATOM   1948 C  CB  . LYS A 1 285 ? -10.421 -13.765 -24.798 0.35 41.61  ? 548  LYS A CB  1 
ATOM   1949 C  CG  . LYS A 1 285 ? -10.480 -12.804 -23.617 0.35 42.17  ? 548  LYS A CG  1 
ATOM   1950 C  CD  . LYS A 1 285 ? -9.361  -11.776 -23.613 0.35 43.62  ? 548  LYS A CD  1 
ATOM   1951 C  CE  . LYS A 1 285 ? -9.424  -10.817 -22.440 0.35 44.34  ? 548  LYS A CE  1 
ATOM   1952 N  NZ  . LYS A 1 285 ? -8.161  -10.053 -22.287 0.35 45.00  ? 548  LYS A NZ  1 
ATOM   1953 N  N   . ASN A 1 286 ? -10.795 -16.394 -26.591 1.00 38.06  ? 549  ASN A N   1 
ATOM   1954 C  CA  . ASN A 1 286 ? -10.923 -17.100 -27.899 1.00 38.03  ? 549  ASN A CA  1 
ATOM   1955 C  C   . ASN A 1 286 ? -12.185 -17.982 -27.934 1.00 33.93  ? 549  ASN A C   1 
ATOM   1956 O  O   . ASN A 1 286 ? -12.830 -18.050 -28.983 1.00 32.69  ? 549  ASN A O   1 
ATOM   1957 C  CB  . ASN A 1 286 ? -9.662  -17.879 -28.222 1.00 40.83  ? 549  ASN A CB  1 
ATOM   1958 C  CG  . ASN A 1 286 ? -8.492  -16.934 -28.407 1.00 46.32  ? 549  ASN A CG  1 
ATOM   1959 O  OD1 . ASN A 1 286 ? -8.581  -15.935 -29.129 1.00 39.52  ? 549  ASN A OD1 1 
ATOM   1960 N  ND2 . ASN A 1 286 ? -7.410  -17.220 -27.720 1.00 45.52  ? 549  ASN A ND2 1 
ATOM   1961 N  N   . GLU A 1 287 ? -12.550 -18.618 -26.820 1.00 34.26  ? 550  GLU A N   1 
ATOM   1962 C  CA  . GLU A 1 287 ? -13.805 -19.422 -26.720 1.00 37.40  ? 550  GLU A CA  1 
ATOM   1963 C  C   . GLU A 1 287 ? -15.053 -18.525 -26.925 1.00 37.17  ? 550  GLU A C   1 
ATOM   1964 O  O   . GLU A 1 287 ? -16.020 -18.982 -27.603 1.00 36.32  ? 550  GLU A O   1 
ATOM   1965 C  CB  . GLU A 1 287 ? -13.819 -20.193 -25.394 1.00 35.47  ? 550  GLU A CB  1 
ATOM   1966 C  CG  . GLU A 1 287 ? -12.751 -21.264 -25.368 1.00 38.00  ? 550  GLU A CG  1 
ATOM   1967 C  CD  . GLU A 1 287 ? -12.432 -21.853 -24.012 1.00 41.21  ? 550  GLU A CD  1 
ATOM   1968 O  OE1 . GLU A 1 287 ? -13.162 -21.538 -23.035 1.00 41.08  ? 550  GLU A OE1 1 
ATOM   1969 O  OE2 . GLU A 1 287 ? -11.470 -22.660 -23.947 1.00 39.66  ? 550  GLU A OE2 1 
ATOM   1970 N  N   A GLU A 1 288 ? -15.035 -17.304 -26.368 0.17 38.15  ? 551  GLU A N   1 
ATOM   1971 N  N   B GLU A 1 288 ? -15.011 -17.304 -26.379 0.18 36.47  ? 551  GLU A N   1 
ATOM   1972 C  CA  A GLU A 1 288 ? -16.155 -16.316 -26.435 0.17 39.27  ? 551  GLU A CA  1 
ATOM   1973 C  CA  B GLU A 1 288 ? -16.102 -16.289 -26.420 0.18 36.59  ? 551  GLU A CA  1 
ATOM   1974 C  C   A GLU A 1 288 ? -16.456 -15.948 -27.896 0.17 37.39  ? 551  GLU A C   1 
ATOM   1975 C  C   B GLU A 1 288 ? -16.427 -15.902 -27.870 0.18 35.80  ? 551  GLU A C   1 
ATOM   1976 O  O   A GLU A 1 288 ? -17.621 -15.616 -28.184 0.17 38.98  ? 551  GLU A O   1 
ATOM   1977 O  O   B GLU A 1 288 ? -17.581 -15.508 -28.122 0.18 37.67  ? 551  GLU A O   1 
ATOM   1978 C  CB  A GLU A 1 288 ? -15.854 -15.047 -25.626 0.17 41.20  ? 551  GLU A CB  1 
ATOM   1979 C  CB  B GLU A 1 288 ? -15.701 -15.065 -25.590 0.18 36.26  ? 551  GLU A CB  1 
ATOM   1980 C  CG  A GLU A 1 288 ? -17.038 -14.084 -25.551 0.17 44.05  ? 551  GLU A CG  1 
ATOM   1981 C  CG  B GLU A 1 288 ? -16.824 -14.061 -25.376 0.18 37.36  ? 551  GLU A CG  1 
ATOM   1982 C  CD  A GLU A 1 288 ? -16.804 -12.730 -24.893 0.17 44.89  ? 551  GLU A CD  1 
ATOM   1983 C  CD  B GLU A 1 288 ? -17.018 -13.016 -26.468 0.18 35.98  ? 551  GLU A CD  1 
ATOM   1984 O  OE1 A GLU A 1 288 ? -15.644 -12.434 -24.542 0.17 47.44  ? 551  GLU A OE1 1 
ATOM   1985 O  OE1 B GLU A 1 288 ? -16.058 -12.729 -27.187 0.18 33.89  ? 551  GLU A OE1 1 
ATOM   1986 O  OE2 A GLU A 1 288 ? -17.795 -11.966 -24.736 0.17 42.10  ? 551  GLU A OE2 1 
ATOM   1987 O  OE2 B GLU A 1 288 ? -18.140 -12.493 -26.589 0.18 38.71  ? 551  GLU A OE2 1 
ATOM   1988 N  N   . MET A 1 289 ? -15.468 -16.034 -28.790 1.00 35.03  ? 552  MET A N   1 
ATOM   1989 C  CA  . MET A 1 289 ? -15.667 -15.675 -30.220 1.00 35.84  ? 552  MET A CA  1 
ATOM   1990 C  C   . MET A 1 289 ? -16.757 -16.527 -30.867 1.00 38.92  ? 552  MET A C   1 
ATOM   1991 O  O   . MET A 1 289 ? -17.176 -16.202 -32.023 1.00 43.36  ? 552  MET A O   1 
ATOM   1992 C  CB  . MET A 1 289 ? -14.364 -15.805 -31.013 1.00 36.01  ? 552  MET A CB  1 
ATOM   1993 C  CG  . MET A 1 289 ? -13.318 -14.798 -30.556 1.00 38.98  ? 552  MET A CG  1 
ATOM   1994 S  SD  . MET A 1 289 ? -12.017 -14.415 -31.794 1.00 48.94  ? 552  MET A SD  1 
ATOM   1995 C  CE  . MET A 1 289 ? -11.727 -15.991 -32.575 1.00 46.25  ? 552  MET A CE  1 
ATOM   1996 N  N   . VAL A 1 290 ? -17.233 -17.595 -30.216 1.00 36.84  ? 553  VAL A N   1 
ATOM   1997 C  CA  . VAL A 1 290 ? -18.425 -18.313 -30.765 1.00 35.86  ? 553  VAL A CA  1 
ATOM   1998 C  C   . VAL A 1 290 ? -19.596 -17.312 -30.862 1.00 32.77  ? 553  VAL A C   1 
ATOM   1999 O  O   . VAL A 1 290 ? -20.417 -17.491 -31.786 1.00 36.92  ? 553  VAL A O   1 
ATOM   2000 C  CB  . VAL A 1 290 ? -18.803 -19.564 -29.948 1.00 30.46  ? 553  VAL A CB  1 
ATOM   2001 C  CG1 . VAL A 1 290 ? -19.223 -19.230 -28.510 1.00 32.90  ? 553  VAL A CG1 1 
ATOM   2002 C  CG2 . VAL A 1 290 ? -19.880 -20.379 -30.651 1.00 32.72  ? 553  VAL A CG2 1 
ATOM   2003 N  N   . THR A 1 291 ? -19.711 -16.341 -29.933 1.00 33.36  ? 554  THR A N   1 
ATOM   2004 C  CA  . THR A 1 291 ? -20.778 -15.282 -29.943 1.00 36.00  ? 554  THR A CA  1 
ATOM   2005 C  C   . THR A 1 291 ? -20.771 -14.448 -31.233 1.00 37.78  ? 554  THR A C   1 
ATOM   2006 O  O   . THR A 1 291 ? -21.887 -13.988 -31.632 1.00 40.60  ? 554  THR A O   1 
ATOM   2007 C  CB  . THR A 1 291 ? -20.709 -14.344 -28.747 1.00 33.41  ? 554  THR A CB  1 
ATOM   2008 O  OG1 . THR A 1 291 ? -19.447 -13.686 -28.800 1.00 35.67  ? 554  THR A OG1 1 
ATOM   2009 C  CG2 . THR A 1 291 ? -20.893 -15.091 -27.449 1.00 31.55  ? 554  THR A CG2 1 
ATOM   2010 N  N   . ASN A 1 292 ? -19.631 -14.311 -31.908 1.00 39.07  ? 555  ASN A N   1 
ATOM   2011 C  CA  . ASN A 1 292 ? -19.561 -13.629 -33.239 1.00 42.21  ? 555  ASN A CA  1 
ATOM   2012 C  C   . ASN A 1 292 ? -20.450 -14.320 -34.273 1.00 44.28  ? 555  ASN A C   1 
ATOM   2013 O  O   . ASN A 1 292 ? -20.625 -13.736 -35.377 1.00 46.61  ? 555  ASN A O   1 
ATOM   2014 C  CB  . ASN A 1 292 ? -18.172 -13.609 -33.876 1.00 40.23  ? 555  ASN A CB  1 
ATOM   2015 C  CG  . ASN A 1 292 ? -17.154 -12.925 -33.000 1.00 44.55  ? 555  ASN A CG  1 
ATOM   2016 O  OD1 . ASN A 1 292 ? -17.501 -12.256 -32.028 1.00 44.90  ? 555  ASN A OD1 1 
ATOM   2017 N  ND2 . ASN A 1 292 ? -15.892 -13.125 -33.324 1.00 49.31  ? 555  ASN A ND2 1 
ATOM   2018 N  N   . HIS A 1 293 ? -20.961 -15.524 -33.997 1.00 41.23  ? 556  HIS A N   1 
ATOM   2019 C  CA  . HIS A 1 293 ? -21.768 -16.294 -34.993 1.00 42.37  ? 556  HIS A CA  1 
ATOM   2020 C  C   . HIS A 1 293 ? -23.251 -16.261 -34.642 1.00 38.78  ? 556  HIS A C   1 
ATOM   2021 O  O   . HIS A 1 293 ? -24.027 -16.913 -35.356 1.00 36.23  ? 556  HIS A O   1 
ATOM   2022 C  CB  . HIS A 1 293 ? -21.236 -17.724 -35.131 1.00 42.21  ? 556  HIS A CB  1 
ATOM   2023 C  CG  . HIS A 1 293 ? -19.846 -17.722 -35.648 1.00 44.86  ? 556  HIS A CG  1 
ATOM   2024 N  ND1 . HIS A 1 293 ? -19.578 -17.891 -36.976 1.00 44.62  ? 556  HIS A ND1 1 
ATOM   2025 C  CD2 . HIS A 1 293 ? -18.662 -17.510 -35.031 1.00 45.64  ? 556  HIS A CD2 1 
ATOM   2026 C  CE1 . HIS A 1 293 ? -18.276 -17.788 -37.168 1.00 44.93  ? 556  HIS A CE1 1 
ATOM   2027 N  NE2 . HIS A 1 293 ? -17.697 -17.545 -35.996 1.00 45.67  ? 556  HIS A NE2 1 
ATOM   2028 N  N   . MET A 1 294 ? -23.569 -15.611 -33.529 1.00 36.19  ? 557  MET A N   1 
ATOM   2029 C  CA  . MET A 1 294 ? -24.902 -15.550 -32.903 1.00 41.67  ? 557  MET A CA  1 
ATOM   2030 C  C   . MET A 1 294 ? -25.547 -14.195 -33.256 1.00 47.21  ? 557  MET A C   1 
ATOM   2031 O  O   . MET A 1 294 ? -24.936 -13.401 -33.979 1.00 46.27  ? 557  MET A O   1 
ATOM   2032 C  CB  . MET A 1 294 ? -24.809 -15.643 -31.378 1.00 42.23  ? 557  MET A CB  1 
ATOM   2033 C  CG  . MET A 1 294 ? -24.177 -16.932 -30.836 1.00 39.32  ? 557  MET A CG  1 
ATOM   2034 S  SD  . MET A 1 294 ? -24.240 -16.927 -29.047 1.00 41.08  ? 557  MET A SD  1 
ATOM   2035 C  CE  . MET A 1 294 ? -23.237 -18.373 -28.687 1.00 42.19  ? 557  MET A CE  1 
ATOM   2036 N  N   . GLU A 1 295 ? -26.762 -13.961 -32.769 1.00 50.72  ? 558  GLU A N   1 
ATOM   2037 C  CA  . GLU A 1 295 ? -27.522 -12.722 -33.054 1.00 52.41  ? 558  GLU A CA  1 
ATOM   2038 C  C   . GLU A 1 295 ? -28.627 -12.504 -32.038 1.00 48.81  ? 558  GLU A C   1 
ATOM   2039 O  O   . GLU A 1 295 ? -28.973 -13.454 -31.307 1.00 47.69  ? 558  GLU A O   1 
ATOM   2040 C  CB  . GLU A 1 295 ? -28.185 -12.821 -34.414 1.00 47.79  ? 558  GLU A CB  1 
ATOM   2041 C  CG  . GLU A 1 295 ? -29.373 -13.732 -34.461 1.00 50.26  ? 558  GLU A CG  1 
ATOM   2042 C  CD  . GLU A 1 295 ? -29.856 -13.946 -35.879 1.00 61.15  ? 558  GLU A CD  1 
ATOM   2043 O  OE1 . GLU A 1 295 ? -29.004 -13.936 -36.820 1.00 69.82  ? 558  GLU A OE1 1 
ATOM   2044 O  OE2 . GLU A 1 295 ? -31.081 -14.079 -36.046 1.00 64.07  ? 558  GLU A OE2 1 
ATOM   2045 N  N   . GLY A 1 296 ? -29.210 -11.309 -32.091 1.00 53.21  ? 559  GLY A N   1 
ATOM   2046 C  CA  . GLY A 1 296 ? -30.400 -10.964 -31.304 1.00 45.15  ? 559  GLY A CA  1 
ATOM   2047 C  C   . GLY A 1 296 ? -30.117 -11.155 -29.834 1.00 49.17  ? 559  GLY A C   1 
ATOM   2048 O  O   . GLY A 1 296 ? -28.924 -10.884 -29.412 1.00 47.56  ? 559  GLY A O   1 
ATOM   2049 N  N   . GLU A 1 297 ? -31.144 -11.637 -29.119 1.00 41.50  ? 560  GLU A N   1 
ATOM   2050 C  CA  . GLU A 1 297 ? -31.106 -11.943 -27.672 1.00 50.38  ? 560  GLU A CA  1 
ATOM   2051 C  C   . GLU A 1 297 ? -29.965 -12.948 -27.403 1.00 54.23  ? 560  GLU A C   1 
ATOM   2052 O  O   . GLU A 1 297 ? -29.248 -12.811 -26.386 1.00 51.37  ? 560  GLU A O   1 
ATOM   2053 C  CB  . GLU A 1 297 ? -32.459 -12.506 -27.251 1.00 57.14  ? 560  GLU A CB  1 
ATOM   2054 C  CG  . GLU A 1 297 ? -32.863 -12.098 -25.852 1.00 67.00  ? 560  GLU A CG  1 
ATOM   2055 C  CD  . GLU A 1 297 ? -34.255 -12.532 -25.433 1.00 73.53  ? 560  GLU A CD  1 
ATOM   2056 O  OE1 . GLU A 1 297 ? -34.421 -13.718 -25.091 1.00 80.94  ? 560  GLU A OE1 1 
ATOM   2057 O  OE2 . GLU A 1 297 ? -35.159 -11.673 -25.413 1.00 91.20  ? 560  GLU A OE2 1 
ATOM   2058 N  N   . HIS A 1 298 ? -29.806 -13.937 -28.285 1.00 49.48  ? 561  HIS A N   1 
ATOM   2059 C  CA  . HIS A 1 298 ? -28.929 -15.105 -28.044 1.00 49.36  ? 561  HIS A CA  1 
ATOM   2060 C  C   . HIS A 1 298 ? -27.523 -14.552 -27.809 1.00 46.18  ? 561  HIS A C   1 
ATOM   2061 O  O   . HIS A 1 298 ? -26.962 -14.786 -26.705 1.00 47.79  ? 561  HIS A O   1 
ATOM   2062 C  CB  . HIS A 1 298 ? -29.057 -16.144 -29.168 1.00 48.35  ? 561  HIS A CB  1 
ATOM   2063 C  CG  . HIS A 1 298 ? -28.208 -17.349 -28.917 1.00 49.73  ? 561  HIS A CG  1 
ATOM   2064 N  ND1 . HIS A 1 298 ? -27.685 -18.120 -29.939 1.00 46.29  ? 561  HIS A ND1 1 
ATOM   2065 C  CD2 . HIS A 1 298 ? -27.762 -17.889 -27.759 1.00 43.80  ? 561  HIS A CD2 1 
ATOM   2066 C  CE1 . HIS A 1 298 ? -26.965 -19.091 -29.415 1.00 49.13  ? 561  HIS A CE1 1 
ATOM   2067 N  NE2 . HIS A 1 298 ? -27.012 -18.981 -28.074 1.00 46.30  ? 561  HIS A NE2 1 
ATOM   2068 N  N   . LYS A 1 299 ? -27.061 -13.732 -28.747 1.00 38.89  ? 562  LYS A N   1 
ATOM   2069 C  CA  . LYS A 1 299 ? -25.707 -13.149 -28.751 1.00 44.99  ? 562  LYS A CA  1 
ATOM   2070 C  C   . LYS A 1 299 ? -25.484 -12.479 -27.404 1.00 50.48  ? 562  LYS A C   1 
ATOM   2071 O  O   . LYS A 1 299 ? -24.374 -12.639 -26.830 1.00 52.83  ? 562  LYS A O   1 
ATOM   2072 C  CB  . LYS A 1 299 ? -25.530 -12.144 -29.886 1.00 45.25  ? 562  LYS A CB  1 
ATOM   2073 C  CG  . LYS A 1 299 ? -24.187 -11.431 -29.891 1.00 44.48  ? 562  LYS A CG  1 
ATOM   2074 C  CD  . LYS A 1 299 ? -23.915 -10.757 -31.225 1.00 51.34  ? 562  LYS A CD  1 
ATOM   2075 C  CE  . LYS A 1 299 ? -22.665 -9.907  -31.254 1.00 50.75  ? 562  LYS A CE  1 
ATOM   2076 N  NZ  . LYS A 1 299 ? -21.665 -10.488 -32.178 1.00 55.33  ? 562  LYS A NZ  1 
ATOM   2077 N  N   . LYS A 1 300 ? -26.497 -11.769 -26.917 1.00 52.70  ? 563  LYS A N   1 
ATOM   2078 C  CA  . LYS A 1 300 ? -26.375 -10.982 -25.661 1.00 53.69  ? 563  LYS A CA  1 
ATOM   2079 C  C   . LYS A 1 300 ? -26.344 -11.952 -24.490 1.00 40.10  ? 563  LYS A C   1 
ATOM   2080 O  O   . LYS A 1 300 ? -25.557 -11.738 -23.611 1.00 47.22  ? 563  LYS A O   1 
ATOM   2081 C  CB  . LYS A 1 300 ? -27.505 -9.952  -25.483 1.00 65.27  ? 563  LYS A CB  1 
ATOM   2082 C  CG  . LYS A 1 300 ? -27.561 -8.841  -26.534 1.00 71.27  ? 563  LYS A CG  1 
ATOM   2083 C  CD  . LYS A 1 300 ? -26.331 -7.946  -26.608 1.00 74.73  ? 563  LYS A CD  1 
ATOM   2084 C  CE  . LYS A 1 300 ? -26.045 -7.435  -28.009 1.00 81.86  ? 563  LYS A CE  1 
ATOM   2085 N  NZ  . LYS A 1 300 ? -25.002 -6.377  -28.017 1.00 82.28  ? 563  LYS A NZ  1 
ATOM   2086 N  N   . LEU A 1 301 ? -27.217 -12.951 -24.469 1.00 44.80  ? 564  LEU A N   1 
ATOM   2087 C  CA  . LEU A 1 301 ? -27.279 -13.928 -23.345 1.00 46.80  ? 564  LEU A CA  1 
ATOM   2088 C  C   . LEU A 1 301 ? -25.917 -14.678 -23.224 1.00 51.89  ? 564  LEU A C   1 
ATOM   2089 O  O   . LEU A 1 301 ? -25.357 -14.793 -22.091 1.00 51.04  ? 564  LEU A O   1 
ATOM   2090 C  CB  . LEU A 1 301 ? -28.472 -14.860 -23.588 1.00 44.66  ? 564  LEU A CB  1 
ATOM   2091 C  CG  . LEU A 1 301 ? -29.880 -14.302 -23.286 1.00 43.47  ? 564  LEU A CG  1 
ATOM   2092 C  CD1 . LEU A 1 301 ? -30.944 -15.257 -23.768 1.00 38.85  ? 564  LEU A CD1 1 
ATOM   2093 C  CD2 . LEU A 1 301 ? -30.106 -14.060 -21.789 1.00 46.26  ? 564  LEU A CD2 1 
ATOM   2094 N  N   . ALA A 1 302 ? -25.352 -15.129 -24.342 1.00 47.53  ? 565  ALA A N   1 
ATOM   2095 C  CA  . ALA A 1 302 ? -24.097 -15.915 -24.388 1.00 46.82  ? 565  ALA A CA  1 
ATOM   2096 C  C   . ALA A 1 302 ? -22.957 -15.015 -23.915 1.00 50.39  ? 565  ALA A C   1 
ATOM   2097 O  O   . ALA A 1 302 ? -22.184 -15.471 -23.061 1.00 51.02  ? 565  ALA A O   1 
ATOM   2098 C  CB  . ALA A 1 302 ? -23.853 -16.457 -25.780 1.00 42.19  ? 565  ALA A CB  1 
ATOM   2099 N  N   . GLU A 1 303 ? -22.909 -13.775 -24.419 1.00 46.40  ? 566  GLU A N   1 
ATOM   2100 C  CA  . GLU A 1 303 ? -21.887 -12.749 -24.078 1.00 46.48  ? 566  GLU A CA  1 
ATOM   2101 C  C   . GLU A 1 303 ? -21.845 -12.538 -22.563 1.00 44.03  ? 566  GLU A C   1 
ATOM   2102 O  O   . GLU A 1 303 ? -20.751 -12.281 -22.029 1.00 42.63  ? 566  GLU A O   1 
ATOM   2103 C  CB  . GLU A 1 303 ? -22.181 -11.405 -24.751 1.00 47.74  ? 566  GLU A CB  1 
ATOM   2104 C  CG  . GLU A 1 303 ? -21.827 -11.398 -26.212 1.00 54.68  ? 566  GLU A CG  1 
ATOM   2105 C  CD  . GLU A 1 303 ? -22.037 -10.096 -26.959 1.00 58.67  ? 566  GLU A CD  1 
ATOM   2106 O  OE1 . GLU A 1 303 ? -22.384 -9.097  -26.316 1.00 70.51  ? 566  GLU A OE1 1 
ATOM   2107 O  OE2 . GLU A 1 303 ? -21.825 -10.090 -28.192 1.00 60.58  ? 566  GLU A OE2 1 
ATOM   2108 N  N   . ALA A 1 304 ? -22.991 -12.626 -21.900 1.00 41.26  ? 567  ALA A N   1 
ATOM   2109 C  CA  . ALA A 1 304 ? -23.108 -12.385 -20.447 1.00 45.92  ? 567  ALA A CA  1 
ATOM   2110 C  C   . ALA A 1 304 ? -22.550 -13.594 -19.690 1.00 40.84  ? 567  ALA A C   1 
ATOM   2111 O  O   . ALA A 1 304 ? -21.869 -13.394 -18.681 1.00 43.57  ? 567  ALA A O   1 
ATOM   2112 C  CB  . ALA A 1 304 ? -24.548 -12.078 -20.066 1.00 43.32  ? 567  ALA A CB  1 
ATOM   2113 N  N   . ILE A 1 305 ? -22.877 -14.800 -20.143 1.00 43.71  ? 568  ILE A N   1 
ATOM   2114 C  CA  . ILE A 1 305 ? -22.355 -16.050 -19.533 1.00 42.26  ? 568  ILE A CA  1 
ATOM   2115 C  C   . ILE A 1 305 ? -20.825 -15.966 -19.550 1.00 39.96  ? 568  ILE A C   1 
ATOM   2116 O  O   . ILE A 1 305 ? -20.222 -16.110 -18.486 1.00 39.19  ? 568  ILE A O   1 
ATOM   2117 C  CB  . ILE A 1 305 ? -22.896 -17.291 -20.268 1.00 48.86  ? 568  ILE A CB  1 
ATOM   2118 C  CG1 . ILE A 1 305 ? -24.392 -17.517 -19.984 1.00 47.11  ? 568  ILE A CG1 1 
ATOM   2119 C  CG2 . ILE A 1 305 ? -22.046 -18.538 -19.946 1.00 47.56  ? 568  ILE A CG2 1 
ATOM   2120 C  CD1 . ILE A 1 305 ? -24.778 -17.594 -18.510 1.00 44.46  ? 568  ILE A CD1 1 
ATOM   2121 N  N   . PHE A 1 306 ? -20.236 -15.665 -20.707 1.00 40.19  ? 569  PHE A N   1 
ATOM   2122 C  CA  . PHE A 1 306 ? -18.766 -15.563 -20.923 1.00 45.07  ? 569  PHE A CA  1 
ATOM   2123 C  C   . PHE A 1 306 ? -18.144 -14.460 -20.043 1.00 49.90  ? 569  PHE A C   1 
ATOM   2124 O  O   . PHE A 1 306 ? -17.157 -14.770 -19.313 1.00 45.77  ? 569  PHE A O   1 
ATOM   2125 C  CB  . PHE A 1 306 ? -18.455 -15.350 -22.409 1.00 42.45  ? 569  PHE A CB  1 
ATOM   2126 C  CG  . PHE A 1 306 ? -18.321 -16.631 -23.194 1.00 44.52  ? 569  PHE A CG  1 
ATOM   2127 C  CD1 . PHE A 1 306 ? -17.196 -17.431 -23.050 1.00 47.30  ? 569  PHE A CD1 1 
ATOM   2128 C  CD2 . PHE A 1 306 ? -19.302 -17.037 -24.081 1.00 43.89  ? 569  PHE A CD2 1 
ATOM   2129 C  CE1 . PHE A 1 306 ? -17.075 -18.618 -23.758 1.00 48.19  ? 569  PHE A CE1 1 
ATOM   2130 C  CE2 . PHE A 1 306 ? -19.175 -18.217 -24.799 1.00 48.27  ? 569  PHE A CE2 1 
ATOM   2131 C  CZ  . PHE A 1 306 ? -18.071 -19.022 -24.616 1.00 47.44  ? 569  PHE A CZ  1 
ATOM   2132 N  N   . LYS A 1 307 ? -18.668 -13.225 -20.107 1.00 51.89  ? 570  LYS A N   1 
ATOM   2133 C  CA  . LYS A 1 307 ? -18.191 -12.054 -19.305 1.00 49.55  ? 570  LYS A CA  1 
ATOM   2134 C  C   . LYS A 1 307 ? -18.348 -12.311 -17.808 1.00 46.43  ? 570  LYS A C   1 
ATOM   2135 O  O   . LYS A 1 307 ? -17.365 -12.170 -17.112 1.00 49.65  ? 570  LYS A O   1 
ATOM   2136 C  CB  . LYS A 1 307 ? -18.962 -10.765 -19.613 1.00 58.03  ? 570  LYS A CB  1 
ATOM   2137 C  CG  . LYS A 1 307 ? -18.359 -9.930  -20.727 1.00 61.96  ? 570  LYS A CG  1 
ATOM   2138 C  CD  . LYS A 1 307 ? -18.979 -8.562  -20.922 1.00 74.58  ? 570  LYS A CD  1 
ATOM   2139 C  CE  . LYS A 1 307 ? -18.483 -7.886  -22.185 1.00 82.95  ? 570  LYS A CE  1 
ATOM   2140 N  NZ  . LYS A 1 307 ? -18.555 -8.787  -23.370 1.00 86.42  ? 570  LYS A NZ  1 
ATOM   2141 N  N   . LEU A 1 308 ? -19.539 -12.680 -17.345 1.00 47.86  ? 571  LEU A N   1 
ATOM   2142 C  CA  . LEU A 1 308 ? -19.922 -12.529 -15.921 1.00 50.56  ? 571  LEU A CA  1 
ATOM   2143 C  C   . LEU A 1 308 ? -19.686 -13.820 -15.140 1.00 55.53  ? 571  LEU A C   1 
ATOM   2144 O  O   . LEU A 1 308 ? -19.555 -13.738 -13.882 1.00 59.13  ? 571  LEU A O   1 
ATOM   2145 C  CB  . LEU A 1 308 ? -21.400 -12.125 -15.855 1.00 53.69  ? 571  LEU A CB  1 
ATOM   2146 C  CG  . LEU A 1 308 ? -21.767 -10.906 -16.707 1.00 55.95  ? 571  LEU A CG  1 
ATOM   2147 C  CD1 . LEU A 1 308 ? -23.276 -10.766 -16.791 1.00 59.74  ? 571  LEU A CD1 1 
ATOM   2148 C  CD2 . LEU A 1 308 ? -21.118 -9.629  -16.168 1.00 50.28  ? 571  LEU A CD2 1 
ATOM   2149 N  N   . THR A 1 309 ? -19.735 -14.976 -15.800 1.00 49.44  ? 572  THR A N   1 
ATOM   2150 C  CA  . THR A 1 309 ? -19.668 -16.279 -15.087 1.00 51.56  ? 572  THR A CA  1 
ATOM   2151 C  C   . THR A 1 309 ? -18.338 -16.980 -15.370 1.00 45.88  ? 572  THR A C   1 
ATOM   2152 O  O   . THR A 1 309 ? -17.888 -17.641 -14.471 1.00 45.78  ? 572  THR A O   1 
ATOM   2153 C  CB  . THR A 1 309 ? -20.861 -17.184 -15.411 1.00 56.68  ? 572  THR A CB  1 
ATOM   2154 O  OG1 . THR A 1 309 ? -20.872 -17.425 -16.819 1.00 52.17  ? 572  THR A OG1 1 
ATOM   2155 C  CG2 . THR A 1 309 ? -22.176 -16.575 -14.979 1.00 64.98  ? 572  THR A CG2 1 
ATOM   2156 N  N   . TYR A 1 310 ? -17.724 -16.810 -16.539 1.00 44.35  ? 573  TYR A N   1 
ATOM   2157 C  CA  . TYR A 1 310 ? -16.534 -17.608 -16.979 1.00 50.11  ? 573  TYR A CA  1 
ATOM   2158 C  C   . TYR A 1 310 ? -15.269 -16.753 -16.805 1.00 50.61  ? 573  TYR A C   1 
ATOM   2159 O  O   . TYR A 1 310 ? -14.333 -17.229 -16.124 1.00 50.92  ? 573  TYR A O   1 
ATOM   2160 C  CB  . TYR A 1 310 ? -16.643 -18.095 -18.438 1.00 40.28  ? 573  TYR A CB  1 
ATOM   2161 C  CG  . TYR A 1 310 ? -17.674 -19.162 -18.739 1.00 36.02  ? 573  TYR A CG  1 
ATOM   2162 C  CD1 . TYR A 1 310 ? -18.546 -19.646 -17.783 1.00 34.16  ? 573  TYR A CD1 1 
ATOM   2163 C  CD2 . TYR A 1 310 ? -17.814 -19.659 -20.023 1.00 34.71  ? 573  TYR A CD2 1 
ATOM   2164 C  CE1 . TYR A 1 310 ? -19.500 -20.599 -18.082 1.00 34.22  ? 573  TYR A CE1 1 
ATOM   2165 C  CE2 . TYR A 1 310 ? -18.777 -20.603 -20.346 1.00 33.78  ? 573  TYR A CE2 1 
ATOM   2166 C  CZ  . TYR A 1 310 ? -19.602 -21.100 -19.372 1.00 35.82  ? 573  TYR A CZ  1 
ATOM   2167 O  OH  . TYR A 1 310 ? -20.566 -22.017 -19.704 1.00 37.10  ? 573  TYR A OH  1 
ATOM   2168 N  N   . GLN A 1 311 ? -15.263 -15.533 -17.370 1.00 42.19  ? 574  GLN A N   1 
ATOM   2169 C  CA  . GLN A 1 311 ? -14.112 -14.599 -17.337 1.00 44.54  ? 574  GLN A CA  1 
ATOM   2170 C  C   . GLN A 1 311 ? -14.016 -13.808 -16.014 1.00 44.99  ? 574  GLN A C   1 
ATOM   2171 O  O   . GLN A 1 311 ? -12.978 -13.156 -15.790 1.00 43.62  ? 574  GLN A O   1 
ATOM   2172 C  CB  . GLN A 1 311 ? -14.135 -13.692 -18.552 1.00 42.36  ? 574  GLN A CB  1 
ATOM   2173 C  CG  . GLN A 1 311 ? -14.042 -14.457 -19.865 1.00 43.84  ? 574  GLN A CG  1 
ATOM   2174 C  CD  . GLN A 1 311 ? -14.217 -13.501 -21.011 1.00 44.07  ? 574  GLN A CD  1 
ATOM   2175 O  OE1 . GLN A 1 311 ? -14.412 -12.330 -20.776 1.00 61.10  ? 574  GLN A OE1 1 
ATOM   2176 N  NE2 . GLN A 1 311 ? -14.113 -13.967 -22.249 1.00 51.75  ? 574  GLN A NE2 1 
ATOM   2177 N  N   . ASN A 1 312 ? -15.048 -13.843 -15.165 0.35 45.21  ? 575  ASN A N   1 
ATOM   2178 C  CA  . ASN A 1 312 ? -15.082 -13.075 -13.888 0.35 46.83  ? 575  ASN A CA  1 
ATOM   2179 C  C   . ASN A 1 312 ? -15.832 -13.899 -12.834 0.35 46.76  ? 575  ASN A C   1 
ATOM   2180 O  O   . ASN A 1 312 ? -16.968 -13.528 -12.481 0.35 47.83  ? 575  ASN A O   1 
ATOM   2181 C  CB  . ASN A 1 312 ? -15.686 -11.678 -14.088 0.35 44.83  ? 575  ASN A CB  1 
ATOM   2182 C  CG  . ASN A 1 312 ? -14.890 -10.817 -15.050 0.35 45.51  ? 575  ASN A CG  1 
ATOM   2183 O  OD1 . ASN A 1 312 ? -13.716 -10.537 -14.819 0.35 46.01  ? 575  ASN A OD1 1 
ATOM   2184 N  ND2 . ASN A 1 312 ? -15.513 -10.384 -16.135 0.35 44.70  ? 575  ASN A ND2 1 
ATOM   2185 N  N   . LYS A 1 313 ? -15.192 -14.958 -12.333 0.35 49.03  ? 576  LYS A N   1 
ATOM   2186 C  CA  . LYS A 1 313 ? -15.822 -16.014 -11.493 0.35 51.14  ? 576  LYS A CA  1 
ATOM   2187 C  C   . LYS A 1 313 ? -15.830 -15.589 -10.021 0.35 51.65  ? 576  LYS A C   1 
ATOM   2188 O  O   . LYS A 1 313 ? -14.937 -14.818 -9.627  0.35 52.82  ? 576  LYS A O   1 
ATOM   2189 C  CB  . LYS A 1 313 ? -15.059 -17.340 -11.590 0.35 52.71  ? 576  LYS A CB  1 
ATOM   2190 C  CG  . LYS A 1 313 ? -14.609 -17.772 -12.979 0.35 52.75  ? 576  LYS A CG  1 
ATOM   2191 C  CD  . LYS A 1 313 ? -14.073 -19.185 -12.987 0.35 53.70  ? 576  LYS A CD  1 
ATOM   2192 C  CE  . LYS A 1 313 ? -13.559 -19.635 -14.336 0.35 54.60  ? 576  LYS A CE  1 
ATOM   2193 N  NZ  . LYS A 1 313 ? -12.451 -18.778 -14.812 0.35 55.74  ? 576  LYS A NZ  1 
ATOM   2194 N  N   . VAL A 1 314 ? -16.788 -16.114 -9.250  0.35 50.80  ? 577  VAL A N   1 
ATOM   2195 C  CA  . VAL A 1 314 ? -16.866 -16.022 -7.760  0.35 50.71  ? 577  VAL A CA  1 
ATOM   2196 C  C   . VAL A 1 314 ? -17.334 -17.390 -7.254  0.35 49.84  ? 577  VAL A C   1 
ATOM   2197 O  O   . VAL A 1 314 ? -18.190 -17.988 -7.933  0.35 47.88  ? 577  VAL A O   1 
ATOM   2198 C  CB  . VAL A 1 314 ? -17.820 -14.901 -7.298  0.35 52.98  ? 577  VAL A CB  1 
ATOM   2199 C  CG1 . VAL A 1 314 ? -17.578 -14.521 -5.845  0.35 52.75  ? 577  VAL A CG1 1 
ATOM   2200 C  CG2 . VAL A 1 314 ? -17.748 -13.669 -8.189  0.35 52.50  ? 577  VAL A CG2 1 
ATOM   2201 N  N   . VAL A 1 315 ? -16.804 -17.868 -6.121  0.35 51.99  ? 578  VAL A N   1 
ATOM   2202 C  CA  . VAL A 1 315 ? -16.989 -19.279 -5.658  0.35 53.63  ? 578  VAL A CA  1 
ATOM   2203 C  C   . VAL A 1 315 ? -17.099 -19.339 -4.128  0.35 54.32  ? 578  VAL A C   1 
ATOM   2204 O  O   . VAL A 1 315 ? -16.424 -18.539 -3.458  0.35 54.69  ? 578  VAL A O   1 
ATOM   2205 C  CB  . VAL A 1 315 ? -15.835 -20.176 -6.147  0.35 54.65  ? 578  VAL A CB  1 
ATOM   2206 C  CG1 . VAL A 1 315 ? -16.162 -21.650 -5.967  0.35 56.00  ? 578  VAL A CG1 1 
ATOM   2207 C  CG2 . VAL A 1 315 ? -15.453 -19.887 -7.592  0.35 55.06  ? 578  VAL A CG2 1 
ATOM   2208 N  N   . ARG A 1 316 ? -17.900 -20.285 -3.620  0.35 57.31  ? 579  ARG A N   1 
ATOM   2209 C  CA  . ARG A 1 316 ? -17.989 -20.676 -2.185  0.35 60.01  ? 579  ARG A CA  1 
ATOM   2210 C  C   . ARG A 1 316 ? -17.032 -21.851 -1.934  0.35 63.00  ? 579  ARG A C   1 
ATOM   2211 O  O   . ARG A 1 316 ? -16.920 -22.711 -2.829  0.35 60.24  ? 579  ARG A O   1 
ATOM   2212 C  CB  . ARG A 1 316 ? -19.427 -21.062 -1.813  0.35 60.42  ? 579  ARG A CB  1 
ATOM   2213 C  CG  . ARG A 1 316 ? -20.418 -19.905 -1.813  0.35 61.26  ? 579  ARG A CG  1 
ATOM   2214 C  CD  . ARG A 1 316 ? -21.550 -20.066 -0.807  0.35 62.08  ? 579  ARG A CD  1 
ATOM   2215 N  NE  . ARG A 1 316 ? -22.412 -21.217 -1.065  0.35 62.77  ? 579  ARG A NE  1 
ATOM   2216 C  CZ  . ARG A 1 316 ? -23.493 -21.546 -0.357  0.35 61.93  ? 579  ARG A CZ  1 
ATOM   2217 N  NH1 . ARG A 1 316 ? -24.197 -22.618 -0.683  0.35 61.65  ? 579  ARG A NH1 1 
ATOM   2218 N  NH2 . ARG A 1 316 ? -23.869 -20.812 0.676   0.35 63.32  ? 579  ARG A NH2 1 
ATOM   2219 N  N   . VAL A 1 317 ? -16.379 -21.886 -0.762  0.35 66.70  ? 580  VAL A N   1 
ATOM   2220 C  CA  . VAL A 1 317 ? -15.336 -22.889 -0.378  0.35 69.75  ? 580  VAL A CA  1 
ATOM   2221 C  C   . VAL A 1 317 ? -15.456 -23.206 1.119   0.35 73.16  ? 580  VAL A C   1 
ATOM   2222 O  O   . VAL A 1 317 ? -15.399 -22.255 1.916   0.35 74.65  ? 580  VAL A O   1 
ATOM   2223 C  CB  . VAL A 1 317 ? -13.924 -22.368 -0.718  0.35 68.93  ? 580  VAL A CB  1 
ATOM   2224 C  CG1 . VAL A 1 317 ? -12.836 -23.132 0.022   0.35 71.04  ? 580  VAL A CG1 1 
ATOM   2225 C  CG2 . VAL A 1 317 ? -13.660 -22.385 -2.215  0.35 68.85  ? 580  VAL A CG2 1 
ATOM   2226 N  N   . GLN A 1 318 ? -15.585 -24.488 1.485   0.35 79.28  ? 581  GLN A N   1 
ATOM   2227 C  CA  . GLN A 1 318 ? -15.587 -24.960 2.901   0.35 83.68  ? 581  GLN A CA  1 
ATOM   2228 C  C   . GLN A 1 318 ? -14.142 -25.144 3.383   0.35 90.35  ? 581  GLN A C   1 
ATOM   2229 O  O   . GLN A 1 318 ? -13.419 -25.961 2.776   0.35 89.77  ? 581  GLN A O   1 
ATOM   2230 C  CB  . GLN A 1 318 ? -16.357 -26.274 3.062   0.35 79.96  ? 581  GLN A CB  1 
ATOM   2231 C  CG  . GLN A 1 318 ? -17.862 -26.087 3.207   0.35 78.57  ? 581  GLN A CG  1 
ATOM   2232 C  CD  . GLN A 1 318 ? -18.452 -26.824 4.387   0.35 76.87  ? 581  GLN A CD  1 
ATOM   2233 O  OE1 . GLN A 1 318 ? -17.845 -27.728 4.959   0.35 74.91  ? 581  GLN A OE1 1 
ATOM   2234 N  NE2 . GLN A 1 318 ? -19.660 -26.436 4.765   0.35 75.77  ? 581  GLN A NE2 1 
ATOM   2235 N  N   . ARG A 1 319 ? -13.757 -24.417 4.439   0.35 99.32  ? 582  ARG A N   1 
ATOM   2236 C  CA  . ARG A 1 319 ? -12.426 -24.498 5.105   0.35 106.85 ? 582  ARG A CA  1 
ATOM   2237 C  C   . ARG A 1 319 ? -12.637 -24.785 6.591   0.35 114.44 ? 582  ARG A C   1 
ATOM   2238 O  O   . ARG A 1 319 ? -13.337 -24.033 7.265   0.35 114.55 ? 582  ARG A O   1 
ATOM   2239 C  CB  . ARG A 1 319 ? -11.655 -23.191 4.895   0.35 106.26 ? 582  ARG A CB  1 
ATOM   2240 C  CG  . ARG A 1 319 ? -10.303 -23.135 5.593   0.35 105.24 ? 582  ARG A CG  1 
ATOM   2241 C  CD  . ARG A 1 319 ? -9.436  -22.006 5.065   0.35 104.79 ? 582  ARG A CD  1 
ATOM   2242 N  NE  . ARG A 1 319 ? -10.051 -20.698 5.266   0.35 103.54 ? 582  ARG A NE  1 
ATOM   2243 C  CZ  . ARG A 1 319 ? -9.553  -19.703 6.001   0.35 106.30 ? 582  ARG A CZ  1 
ATOM   2244 N  NH1 . ARG A 1 319 ? -8.395  -19.829 6.630   0.35 108.56 ? 582  ARG A NH1 1 
ATOM   2245 N  NH2 . ARG A 1 319 ? -10.222 -18.566 6.095   0.35 106.02 ? 582  ARG A NH2 1 
ATOM   2246 N  N   . PRO A 1 320 ? -12.028 -25.859 7.150   1.00 123.93 ? 583  PRO A N   1 
ATOM   2247 C  CA  . PRO A 1 320 ? -12.357 -26.315 8.509   1.00 123.61 ? 583  PRO A CA  1 
ATOM   2248 C  C   . PRO A 1 320 ? -11.720 -25.576 9.699   1.00 121.08 ? 583  PRO A C   1 
ATOM   2249 O  O   . PRO A 1 320 ? -12.076 -25.884 10.824  1.00 114.56 ? 583  PRO A O   1 
ATOM   2250 C  CB  . PRO A 1 320 ? -11.817 -27.754 8.480   1.00 123.76 ? 583  PRO A CB  1 
ATOM   2251 C  CG  . PRO A 1 320 ? -10.593 -27.663 7.591   1.00 124.85 ? 583  PRO A CG  1 
ATOM   2252 C  CD  . PRO A 1 320 ? -10.994 -26.689 6.502   1.00 127.58 ? 583  PRO A CD  1 
ATOM   2253 N  N   . THR A 1 321 ? -10.808 -24.638 9.432   1.00 118.85 ? 584  THR A N   1 
ATOM   2254 C  CA  . THR A 1 321 ? -10.064 -23.853 10.452  1.00 123.28 ? 584  THR A CA  1 
ATOM   2255 C  C   . THR A 1 321 ? -11.020 -22.884 11.161  1.00 109.12 ? 584  THR A C   1 
ATOM   2256 O  O   . THR A 1 321 ? -11.623 -23.308 12.162  1.00 98.04  ? 584  THR A O   1 
ATOM   2257 C  CB  . THR A 1 321 ? -8.895  -23.103 9.799   1.00 134.40 ? 584  THR A CB  1 
ATOM   2258 O  OG1 . THR A 1 321 ? -9.468  -22.142 8.913   1.00 142.64 ? 584  THR A OG1 1 
ATOM   2259 C  CG2 . THR A 1 321 ? -7.938  -24.003 9.044   1.00 131.04 ? 584  THR A CG2 1 
ATOM   2260 N  N   . THR A 1 325 ? -15.234 -24.551 10.899  1.00 99.46  ? 588  THR A N   1 
ATOM   2261 C  CA  . THR A 1 325 ? -15.599 -24.562 9.458   1.00 97.29  ? 588  THR A CA  1 
ATOM   2262 C  C   . THR A 1 325 ? -16.185 -23.196 9.078   1.00 100.58 ? 588  THR A C   1 
ATOM   2263 O  O   . THR A 1 325 ? -17.326 -22.899 9.509   1.00 93.78  ? 588  THR A O   1 
ATOM   2264 C  CB  . THR A 1 325 ? -16.549 -25.718 9.110   1.00 98.96  ? 588  THR A CB  1 
ATOM   2265 O  OG1 . THR A 1 325 ? -15.804 -26.935 9.044   1.00 100.69 ? 588  THR A OG1 1 
ATOM   2266 C  CG2 . THR A 1 325 ? -17.231 -25.535 7.775   1.00 105.51 ? 588  THR A CG2 1 
ATOM   2267 N  N   . VAL A 1 326 ? -15.432 -22.391 8.318   1.00 96.34  ? 589  VAL A N   1 
ATOM   2268 C  CA  . VAL A 1 326 ? -15.966 -21.185 7.619   1.00 98.21  ? 589  VAL A CA  1 
ATOM   2269 C  C   . VAL A 1 326 ? -16.270 -21.583 6.173   1.00 101.23 ? 589  VAL A C   1 
ATOM   2270 O  O   . VAL A 1 326 ? -15.701 -22.595 5.692   1.00 104.33 ? 589  VAL A O   1 
ATOM   2271 C  CB  . VAL A 1 326 ? -15.035 -19.954 7.675   1.00 97.44  ? 589  VAL A CB  1 
ATOM   2272 C  CG1 . VAL A 1 326 ? -14.280 -19.859 8.990   1.00 106.04 ? 589  VAL A CG1 1 
ATOM   2273 C  CG2 . VAL A 1 326 ? -14.067 -19.886 6.500   1.00 99.46  ? 589  VAL A CG2 1 
ATOM   2274 N  N   . MET A 1 327 ? -17.165 -20.826 5.531   1.00 97.44  ? 590  MET A N   1 
ATOM   2275 C  CA  . MET A 1 327 ? -17.325 -20.780 4.056   1.00 90.46  ? 590  MET A CA  1 
ATOM   2276 C  C   . MET A 1 327 ? -16.547 -19.563 3.554   1.00 79.38  ? 590  MET A C   1 
ATOM   2277 O  O   . MET A 1 327 ? -16.860 -18.456 3.973   1.00 77.88  ? 590  MET A O   1 
ATOM   2278 C  CB  . MET A 1 327 ? -18.796 -20.641 3.649   1.00 94.11  ? 590  MET A CB  1 
ATOM   2279 C  CG  . MET A 1 327 ? -19.021 -20.793 2.156   1.00 92.04  ? 590  MET A CG  1 
ATOM   2280 S  SD  . MET A 1 327 ? -18.736 -22.486 1.560   1.00 96.21  ? 590  MET A SD  1 
ATOM   2281 C  CE  . MET A 1 327 ? -20.205 -23.330 2.149   1.00 105.29 ? 590  MET A CE  1 
ATOM   2282 N  N   . ASP A 1 328 ? -15.558 -19.782 2.680   0.35 80.30  ? 591  ASP A N   1 
ATOM   2283 C  CA  . ASP A 1 328 ? -14.715 -18.720 2.064   0.35 81.25  ? 591  ASP A CA  1 
ATOM   2284 C  C   . ASP A 1 328 ? -15.342 -18.280 0.736   0.35 78.67  ? 591  ASP A C   1 
ATOM   2285 O  O   . ASP A 1 328 ? -15.762 -19.162 -0.040  0.35 78.13  ? 591  ASP A O   1 
ATOM   2286 C  CB  . ASP A 1 328 ? -13.278 -19.201 1.848   0.35 83.41  ? 591  ASP A CB  1 
ATOM   2287 C  CG  . ASP A 1 328 ? -12.496 -19.394 3.136   0.35 85.34  ? 591  ASP A CG  1 
ATOM   2288 O  OD1 . ASP A 1 328 ? -12.417 -18.429 3.924   0.35 84.38  ? 591  ASP A OD1 1 
ATOM   2289 O  OD2 . ASP A 1 328 ? -11.975 -20.511 3.345   0.35 84.00  ? 591  ASP A OD2 1 
ATOM   2290 N  N   . ILE A 1 329 ? -15.393 -16.967 0.494   0.35 74.78  ? 592  ILE A N   1 
ATOM   2291 C  CA  . ILE A 1 329 ? -15.898 -16.349 -0.768  0.35 72.89  ? 592  ILE A CA  1 
ATOM   2292 C  C   . ILE A 1 329 ? -14.693 -15.781 -1.521  0.35 72.35  ? 592  ILE A C   1 
ATOM   2293 O  O   . ILE A 1 329 ? -14.124 -14.774 -1.056  0.35 72.07  ? 592  ILE A O   1 
ATOM   2294 C  CB  . ILE A 1 329 ? -16.968 -15.275 -0.477  0.35 74.20  ? 592  ILE A CB  1 
ATOM   2295 C  CG1 . ILE A 1 329 ? -18.127 -15.832 0.356   0.35 75.28  ? 592  ILE A CG1 1 
ATOM   2296 C  CG2 . ILE A 1 329 ? -17.462 -14.636 -1.768  0.35 74.11  ? 592  ILE A CG2 1 
ATOM   2297 C  CD1 . ILE A 1 329 ? -18.830 -17.018 -0.265  0.35 75.28  ? 592  ILE A CD1 1 
ATOM   2298 N  N   . ILE A 1 330 ? -14.332 -16.415 -2.640  0.35 71.30  ? 593  ILE A N   1 
ATOM   2299 C  CA  . ILE A 1 330 ? -13.091 -16.135 -3.422  0.35 69.13  ? 593  ILE A CA  1 
ATOM   2300 C  C   . ILE A 1 330 ? -13.470 -15.897 -4.887  0.35 64.92  ? 593  ILE A C   1 
ATOM   2301 O  O   . ILE A 1 330 ? -14.555 -16.353 -5.292  0.35 63.85  ? 593  ILE A O   1 
ATOM   2302 C  CB  . ILE A 1 330 ? -12.078 -17.288 -3.266  0.35 71.43  ? 593  ILE A CB  1 
ATOM   2303 C  CG1 . ILE A 1 330 ? -12.737 -18.661 -3.439  0.35 72.37  ? 593  ILE A CG1 1 
ATOM   2304 C  CG2 . ILE A 1 330 ? -11.349 -17.178 -1.935  0.35 72.07  ? 593  ILE A CG2 1 
ATOM   2305 C  CD1 . ILE A 1 330 ? -11.760 -19.815 -3.506  0.35 72.64  ? 593  ILE A CD1 1 
ATOM   2306 N  N   . SER A 1 331 ? -12.598 -15.216 -5.637  1.00 63.08  ? 594  SER A N   1 
ATOM   2307 C  CA  . SER A 1 331 ? -12.806 -14.887 -7.066  1.00 59.11  ? 594  SER A CA  1 
ATOM   2308 C  C   . SER A 1 331 ? -11.511 -15.053 -7.868  1.00 59.19  ? 594  SER A C   1 
ATOM   2309 O  O   . SER A 1 331 ? -10.417 -14.957 -7.295  1.00 59.51  ? 594  SER A O   1 
ATOM   2310 C  CB  . SER A 1 331 ? -13.314 -13.476 -7.194  1.00 58.22  ? 594  SER A CB  1 
ATOM   2311 O  OG  . SER A 1 331 ? -12.244 -12.534 -7.198  1.00 55.96  ? 594  SER A OG  1 
ATOM   2312 N  N   . ARG A 1 332 ? -11.652 -15.334 -9.164  0.35 57.20  ? 595  ARG A N   1 
ATOM   2313 C  CA  . ARG A 1 332 ? -10.539 -15.375 -10.147 0.35 57.79  ? 595  ARG A CA  1 
ATOM   2314 C  C   . ARG A 1 332 ? -11.138 -15.289 -11.551 0.35 56.01  ? 595  ARG A C   1 
ATOM   2315 O  O   . ARG A 1 332 ? -12.334 -15.605 -11.701 0.35 57.64  ? 595  ARG A O   1 
ATOM   2316 C  CB  . ARG A 1 332 ? -9.692  -16.641 -9.981  0.35 59.62  ? 595  ARG A CB  1 
ATOM   2317 C  CG  . ARG A 1 332 ? -10.247 -17.872 -10.684 0.35 59.85  ? 595  ARG A CG  1 
ATOM   2318 C  CD  . ARG A 1 332 ? -9.342  -19.082 -10.536 0.35 62.06  ? 595  ARG A CD  1 
ATOM   2319 N  NE  . ARG A 1 332 ? -7.987  -18.843 -11.029 0.35 61.76  ? 595  ARG A NE  1 
ATOM   2320 C  CZ  . ARG A 1 332 ? -6.882  -18.784 -10.282 0.35 60.85  ? 595  ARG A CZ  1 
ATOM   2321 N  NH1 . ARG A 1 332 ? -6.931  -18.949 -8.970  0.35 61.67  ? 595  ARG A NH1 1 
ATOM   2322 N  NH2 . ARG A 1 332 ? -5.714  -18.569 -10.863 0.35 59.46  ? 595  ARG A NH2 1 
ATOM   2323 N  N   . ARG A 1 333 ? -10.326 -14.896 -12.530 0.35 53.76  ? 596  ARG A N   1 
ATOM   2324 C  CA  . ARG A 1 333 ? -10.762 -14.655 -13.929 0.35 54.30  ? 596  ARG A CA  1 
ATOM   2325 C  C   . ARG A 1 333 ? -10.492 -15.901 -14.785 0.35 50.80  ? 596  ARG A C   1 
ATOM   2326 O  O   . ARG A 1 333 ? -11.407 -16.305 -15.531 0.35 43.90  ? 596  ARG A O   1 
ATOM   2327 C  CB  . ARG A 1 333 ? -10.057 -13.405 -14.462 0.35 56.73  ? 596  ARG A CB  1 
ATOM   2328 C  CG  . ARG A 1 333 ? -10.417 -12.136 -13.700 0.35 60.54  ? 596  ARG A CG  1 
ATOM   2329 C  CD  . ARG A 1 333 ? -10.164 -10.871 -14.502 0.35 62.55  ? 596  ARG A CD  1 
ATOM   2330 N  NE  . ARG A 1 333 ? -10.939 -10.851 -15.740 0.35 64.96  ? 596  ARG A NE  1 
ATOM   2331 C  CZ  . ARG A 1 333 ? -10.674 -10.091 -16.801 0.35 66.31  ? 596  ARG A CZ  1 
ATOM   2332 N  NH1 . ARG A 1 333 ? -9.641  -9.261  -16.799 0.35 68.16  ? 596  ARG A NH1 1 
ATOM   2333 N  NH2 . ARG A 1 333 ? -11.446 -10.168 -17.872 0.35 65.82  ? 596  ARG A NH2 1 
ATOM   2334 N  N   . ASP A 1 334 ? -9.290  -16.479 -14.663 0.35 49.75  ? 597  ASP A N   1 
ATOM   2335 C  CA  . ASP A 1 334 ? -8.762  -17.582 -15.517 0.35 49.97  ? 597  ASP A CA  1 
ATOM   2336 C  C   . ASP A 1 334 ? -9.240  -18.947 -14.995 0.35 49.11  ? 597  ASP A C   1 
ATOM   2337 O  O   . ASP A 1 334 ? -9.951  -18.976 -13.968 0.35 46.82  ? 597  ASP A O   1 
ATOM   2338 C  CB  . ASP A 1 334 ? -7.231  -17.535 -15.578 0.35 51.00  ? 597  ASP A CB  1 
ATOM   2339 C  CG  . ASP A 1 334 ? -6.550  -17.804 -14.244 0.35 52.50  ? 597  ASP A CG  1 
ATOM   2340 O  OD1 . ASP A 1 334 ? -7.112  -17.397 -13.206 0.35 51.97  ? 597  ASP A OD1 1 
ATOM   2341 O  OD2 . ASP A 1 334 ? -5.465  -18.427 -14.249 0.35 54.63  ? 597  ASP A OD2 1 
ATOM   2342 N  N   . GLN A 1 335 ? -8.856  -20.026 -15.697 0.35 47.61  ? 598  GLN A N   1 
ATOM   2343 C  CA  . GLN A 1 335 ? -9.127  -21.456 -15.368 0.35 46.01  ? 598  GLN A CA  1 
ATOM   2344 C  C   . GLN A 1 335 ? -10.552 -21.835 -15.789 0.35 46.56  ? 598  GLN A C   1 
ATOM   2345 O  O   . GLN A 1 335 ? -11.360 -20.921 -16.061 0.35 45.87  ? 598  GLN A O   1 
ATOM   2346 C  CB  . GLN A 1 335 ? -8.877  -21.746 -13.886 0.35 45.58  ? 598  GLN A CB  1 
ATOM   2347 C  CG  . GLN A 1 335 ? -7.469  -21.373 -13.436 0.35 45.79  ? 598  GLN A CG  1 
ATOM   2348 C  CD  . GLN A 1 335 ? -7.130  -21.881 -12.055 0.35 44.70  ? 598  GLN A CD  1 
ATOM   2349 O  OE1 . GLN A 1 335 ? -7.993  -22.015 -11.189 0.35 44.43  ? 598  GLN A OE1 1 
ATOM   2350 N  NE2 . GLN A 1 335 ? -5.856  -22.161 -11.839 0.35 43.96  ? 598  GLN A NE2 1 
ATOM   2351 N  N   . ARG A 1 336 ? -10.830 -23.142 -15.864 1.00 47.20  ? 599  ARG A N   1 
ATOM   2352 C  CA  . ARG A 1 336 ? -12.131 -23.669 -16.313 1.00 49.36  ? 599  ARG A CA  1 
ATOM   2353 C  C   . ARG A 1 336 ? -13.024 -23.926 -15.111 1.00 52.55  ? 599  ARG A C   1 
ATOM   2354 O  O   . ARG A 1 336 ? -12.650 -24.674 -14.191 1.00 49.88  ? 599  ARG A O   1 
ATOM   2355 C  CB  . ARG A 1 336 ? -12.029 -24.961 -17.118 1.00 46.24  ? 599  ARG A CB  1 
ATOM   2356 C  CG  . ARG A 1 336 ? -13.381 -25.517 -17.536 1.00 40.67  ? 599  ARG A CG  1 
ATOM   2357 C  CD  . ARG A 1 336 ? -13.961 -24.787 -18.726 1.00 40.61  ? 599  ARG A CD  1 
ATOM   2358 N  NE  . ARG A 1 336 ? -13.133 -25.061 -19.868 1.00 37.68  ? 599  ARG A NE  1 
ATOM   2359 C  CZ  . ARG A 1 336 ? -12.823 -24.199 -20.819 1.00 37.27  ? 599  ARG A CZ  1 
ATOM   2360 N  NH1 . ARG A 1 336 ? -13.338 -22.989 -20.818 1.00 36.19  ? 599  ARG A NH1 1 
ATOM   2361 N  NH2 . ARG A 1 336 ? -12.059 -24.592 -21.826 1.00 37.92  ? 599  ARG A NH2 1 
ATOM   2362 N  N   . GLY A 1 337 ? -14.227 -23.344 -15.146 0.35 55.80  ? 600  GLY A N   1 
ATOM   2363 C  CA  . GLY A 1 337 ? -15.287 -23.522 -14.134 0.35 57.71  ? 600  GLY A CA  1 
ATOM   2364 C  C   . GLY A 1 337 ? -16.662 -23.299 -14.739 0.35 60.46  ? 600  GLY A C   1 
ATOM   2365 O  O   . GLY A 1 337 ? -17.169 -22.160 -14.662 0.35 66.07  ? 600  GLY A O   1 
ATOM   2366 N  N   . SER A 1 338 ? -17.226 -24.345 -15.348 0.35 60.55  ? 601  SER A N   1 
ATOM   2367 C  CA  . SER A 1 338 ? -18.548 -24.352 -16.028 0.35 58.67  ? 601  SER A CA  1 
ATOM   2368 C  C   . SER A 1 338 ? -19.274 -25.661 -15.691 0.35 59.17  ? 601  SER A C   1 
ATOM   2369 O  O   . SER A 1 338 ? -18.743 -26.431 -14.861 0.35 57.42  ? 601  SER A O   1 
ATOM   2370 C  CB  . SER A 1 338 ? -18.385 -24.176 -17.520 0.35 58.63  ? 601  SER A CB  1 
ATOM   2371 O  OG  . SER A 1 338 ? -17.350 -23.253 -17.822 0.35 59.52  ? 601  SER A OG  1 
ATOM   2372 N  N   . GLY A 1 339 ? -20.443 -25.899 -16.297 1.00 58.75  ? 602  GLY A N   1 
ATOM   2373 C  CA  . GLY A 1 339 ? -21.091 -27.219 -16.241 1.00 62.29  ? 602  GLY A CA  1 
ATOM   2374 C  C   . GLY A 1 339 ? -20.197 -28.217 -16.950 1.00 55.90  ? 602  GLY A C   1 
ATOM   2375 O  O   . GLY A 1 339 ? -19.504 -27.788 -17.893 1.00 48.43  ? 602  GLY A O   1 
ATOM   2376 N  N   . GLN A 1 340 ? -20.194 -29.474 -16.511 1.00 54.24  ? 603  GLN A N   1 
ATOM   2377 C  CA  . GLN A 1 340 ? -19.296 -30.503 -17.077 1.00 59.27  ? 603  GLN A CA  1 
ATOM   2378 C  C   . GLN A 1 340 ? -19.527 -30.562 -18.599 1.00 50.90  ? 603  GLN A C   1 
ATOM   2379 O  O   . GLN A 1 340 ? -18.567 -30.838 -19.328 1.00 51.02  ? 603  GLN A O   1 
ATOM   2380 C  CB  . GLN A 1 340 ? -19.469 -31.836 -16.342 1.00 68.56  ? 603  GLN A CB  1 
ATOM   2381 C  CG  . GLN A 1 340 ? -20.908 -32.345 -16.291 1.00 83.59  ? 603  GLN A CG  1 
ATOM   2382 C  CD  . GLN A 1 340 ? -21.070 -33.849 -16.161 1.00 85.98  ? 603  GLN A CD  1 
ATOM   2383 O  OE1 . GLN A 1 340 ? -22.185 -34.376 -16.098 1.00 87.03  ? 603  GLN A OE1 1 
ATOM   2384 N  NE2 . GLN A 1 340 ? -19.959 -34.568 -16.161 1.00 84.42  ? 603  GLN A NE2 1 
ATOM   2385 N  N   . VAL A 1 341 ? -20.734 -30.282 -19.094 1.00 47.37  ? 604  VAL A N   1 
ATOM   2386 C  CA  . VAL A 1 341 ? -21.066 -30.530 -20.532 1.00 43.94  ? 604  VAL A CA  1 
ATOM   2387 C  C   . VAL A 1 341 ? -20.573 -29.365 -21.388 1.00 42.49  ? 604  VAL A C   1 
ATOM   2388 O  O   . VAL A 1 341 ? -19.959 -29.629 -22.450 1.00 38.06  ? 604  VAL A O   1 
ATOM   2389 C  CB  . VAL A 1 341 ? -22.560 -30.793 -20.769 1.00 46.08  ? 604  VAL A CB  1 
ATOM   2390 C  CG1 . VAL A 1 341 ? -22.790 -30.982 -22.257 1.00 46.24  ? 604  VAL A CG1 1 
ATOM   2391 C  CG2 . VAL A 1 341 ? -23.066 -31.997 -19.975 1.00 45.09  ? 604  VAL A CG2 1 
ATOM   2392 N  N   . VAL A 1 342 ? -20.773 -28.113 -20.962 1.00 37.87  ? 605  VAL A N   1 
ATOM   2393 C  CA  . VAL A 1 342 ? -20.104 -26.986 -21.686 1.00 39.04  ? 605  VAL A CA  1 
ATOM   2394 C  C   . VAL A 1 342 ? -18.575 -27.094 -21.524 1.00 36.24  ? 605  VAL A C   1 
ATOM   2395 O  O   . VAL A 1 342 ? -17.866 -26.757 -22.475 1.00 31.07  ? 605  VAL A O   1 
ATOM   2396 C  CB  . VAL A 1 342 ? -20.694 -25.627 -21.262 1.00 41.41  ? 605  VAL A CB  1 
ATOM   2397 C  CG1 . VAL A 1 342 ? -19.946 -24.436 -21.853 1.00 41.08  ? 605  VAL A CG1 1 
ATOM   2398 C  CG2 . VAL A 1 342 ? -22.168 -25.579 -21.645 1.00 44.98  ? 605  VAL A CG2 1 
ATOM   2399 N  N   . THR A 1 343 ? -18.061 -27.524 -20.363 1.00 32.83  ? 606  THR A N   1 
ATOM   2400 C  CA  . THR A 1 343 ? -16.603 -27.741 -20.155 1.00 32.93  ? 606  THR A CA  1 
ATOM   2401 C  C   . THR A 1 343 ? -16.047 -28.731 -21.195 1.00 31.00  ? 606  THR A C   1 
ATOM   2402 O  O   . THR A 1 343 ? -14.992 -28.452 -21.735 1.00 35.43  ? 606  THR A O   1 
ATOM   2403 C  CB  . THR A 1 343 ? -16.311 -28.215 -18.732 1.00 35.19  ? 606  THR A CB  1 
ATOM   2404 O  OG1 . THR A 1 343 ? -16.683 -27.128 -17.889 1.00 36.01  ? 606  THR A OG1 1 
ATOM   2405 C  CG2 . THR A 1 343 ? -14.853 -28.555 -18.512 1.00 37.67  ? 606  THR A CG2 1 
ATOM   2406 N  N   . TYR A 1 344 ? -16.756 -29.831 -21.485 1.00 30.31  ? 607  TYR A N   1 
ATOM   2407 C  CA  . TYR A 1 344 ? -16.321 -30.822 -22.492 1.00 27.48  ? 607  TYR A CA  1 
ATOM   2408 C  C   . TYR A 1 344 ? -16.125 -30.097 -23.833 1.00 28.85  ? 607  TYR A C   1 
ATOM   2409 O  O   . TYR A 1 344 ? -15.095 -30.318 -24.535 1.00 29.43  ? 607  TYR A O   1 
ATOM   2410 C  CB  . TYR A 1 344 ? -17.309 -31.997 -22.568 1.00 28.28  ? 607  TYR A CB  1 
ATOM   2411 C  CG  . TYR A 1 344 ? -16.968 -33.027 -23.630 1.00 28.99  ? 607  TYR A CG  1 
ATOM   2412 C  CD1 . TYR A 1 344 ? -16.030 -34.015 -23.396 1.00 29.16  ? 607  TYR A CD1 1 
ATOM   2413 C  CD2 . TYR A 1 344 ? -17.507 -32.953 -24.902 1.00 26.99  ? 607  TYR A CD2 1 
ATOM   2414 C  CE1 . TYR A 1 344 ? -15.678 -34.939 -24.369 1.00 28.35  ? 607  TYR A CE1 1 
ATOM   2415 C  CE2 . TYR A 1 344 ? -17.168 -33.864 -25.891 1.00 29.49  ? 607  TYR A CE2 1 
ATOM   2416 C  CZ  . TYR A 1 344 ? -16.245 -34.857 -25.627 1.00 30.30  ? 607  TYR A CZ  1 
ATOM   2417 O  OH  . TYR A 1 344 ? -15.883 -35.719 -26.615 1.00 35.02  ? 607  TYR A OH  1 
ATOM   2418 N  N   . GLY A 1 345 ? -17.156 -29.369 -24.284 1.00 28.30  ? 608  GLY A N   1 
ATOM   2419 C  CA  . GLY A 1 345 ? -17.149 -28.791 -25.639 1.00 27.61  ? 608  GLY A CA  1 
ATOM   2420 C  C   . GLY A 1 345 ? -16.053 -27.747 -25.786 1.00 27.59  ? 608  GLY A C   1 
ATOM   2421 O  O   . GLY A 1 345 ? -15.344 -27.782 -26.760 1.00 31.79  ? 608  GLY A O   1 
ATOM   2422 N  N   . LEU A 1 346 ? -15.902 -26.869 -24.806 1.00 26.30  ? 609  LEU A N   1 
ATOM   2423 C  CA  . LEU A 1 346 ? -14.885 -25.802 -24.849 1.00 32.02  ? 609  LEU A CA  1 
ATOM   2424 C  C   . LEU A 1 346 ? -13.478 -26.400 -24.650 1.00 29.74  ? 609  LEU A C   1 
ATOM   2425 O  O   . LEU A 1 346 ? -12.560 -25.885 -25.312 1.00 28.82  ? 609  LEU A O   1 
ATOM   2426 C  CB  . LEU A 1 346 ? -15.224 -24.715 -23.806 1.00 31.01  ? 609  LEU A CB  1 
ATOM   2427 C  CG  . LEU A 1 346 ? -16.538 -23.964 -23.994 1.00 33.90  ? 609  LEU A CG  1 
ATOM   2428 C  CD1 . LEU A 1 346 ? -16.684 -22.882 -22.941 1.00 36.16  ? 609  LEU A CD1 1 
ATOM   2429 C  CD2 . LEU A 1 346 ? -16.629 -23.350 -25.367 1.00 34.16  ? 609  LEU A CD2 1 
ATOM   2430 N  N   . ASN A 1 347 ? -13.312 -27.432 -23.808 1.00 24.29  ? 610  ASN A N   1 
ATOM   2431 C  CA  . ASN A 1 347 ? -12.049 -28.209 -23.741 1.00 23.82  ? 610  ASN A CA  1 
ATOM   2432 C  C   . ASN A 1 347 ? -11.712 -28.789 -25.126 1.00 23.83  ? 610  ASN A C   1 
ATOM   2433 O  O   . ASN A 1 347 ? -10.605 -28.604 -25.575 1.00 24.56  ? 610  ASN A O   1 
ATOM   2434 C  CB  . ASN A 1 347 ? -12.154 -29.271 -22.653 1.00 23.69  ? 610  ASN A CB  1 
ATOM   2435 C  CG  . ASN A 1 347 ? -11.960 -28.645 -21.290 1.00 26.16  ? 610  ASN A CG  1 
ATOM   2436 O  OD1 . ASN A 1 347 ? -11.597 -27.487 -21.175 1.00 28.66  ? 610  ASN A OD1 1 
ATOM   2437 N  ND2 . ASN A 1 347 ? -12.166 -29.399 -20.231 1.00 32.25  ? 610  ASN A ND2 1 
ATOM   2438 N  N   . THR A 1 348 ? -12.650 -29.414 -25.817 1.00 24.77  ? 611  THR A N   1 
ATOM   2439 C  CA  . THR A 1 348 ? -12.381 -30.018 -27.146 1.00 26.58  ? 611  THR A CA  1 
ATOM   2440 C  C   . THR A 1 348 ? -11.907 -28.914 -28.122 1.00 28.27  ? 611  THR A C   1 
ATOM   2441 O  O   . THR A 1 348 ? -10.885 -29.122 -28.866 1.00 27.41  ? 611  THR A O   1 
ATOM   2442 C  CB  . THR A 1 348 ? -13.622 -30.764 -27.631 1.00 25.81  ? 611  THR A CB  1 
ATOM   2443 O  OG1 . THR A 1 348 ? -14.062 -31.676 -26.622 1.00 25.55  ? 611  THR A OG1 1 
ATOM   2444 C  CG2 . THR A 1 348 ? -13.402 -31.469 -28.943 1.00 25.23  ? 611  THR A CG2 1 
ATOM   2445 N  N   . PHE A 1 349 ? -12.625 -27.784 -28.153 1.00 31.71  ? 612  PHE A N   1 
ATOM   2446 C  CA  . PHE A 1 349 ? -12.340 -26.625 -29.040 1.00 30.78  ? 612  PHE A CA  1 
ATOM   2447 C  C   . PHE A 1 349 ? -10.892 -26.151 -28.825 1.00 32.54  ? 612  PHE A C   1 
ATOM   2448 O  O   . PHE A 1 349 ? -10.146 -26.033 -29.786 1.00 29.86  ? 612  PHE A O   1 
ATOM   2449 C  CB  . PHE A 1 349 ? -13.297 -25.463 -28.755 1.00 31.59  ? 612  PHE A CB  1 
ATOM   2450 C  CG  . PHE A 1 349 ? -13.054 -24.268 -29.642 1.00 30.14  ? 612  PHE A CG  1 
ATOM   2451 C  CD1 . PHE A 1 349 ? -13.575 -24.222 -30.928 1.00 32.36  ? 612  PHE A CD1 1 
ATOM   2452 C  CD2 . PHE A 1 349 ? -12.253 -23.227 -29.219 1.00 29.41  ? 612  PHE A CD2 1 
ATOM   2453 C  CE1 . PHE A 1 349 ? -13.334 -23.143 -31.769 1.00 30.02  ? 612  PHE A CE1 1 
ATOM   2454 C  CE2 . PHE A 1 349 ? -12.001 -22.152 -30.058 1.00 31.61  ? 612  PHE A CE2 1 
ATOM   2455 C  CZ  . PHE A 1 349 ? -12.524 -22.117 -31.333 1.00 33.30  ? 612  PHE A CZ  1 
ATOM   2456 N  N   . THR A 1 350 ? -10.554 -25.774 -27.594 1.00 32.23  ? 613  THR A N   1 
ATOM   2457 C  CA  . THR A 1 350 ? -9.247  -25.185 -27.225 1.00 37.05  ? 613  THR A CA  1 
ATOM   2458 C  C   . THR A 1 350 ? -8.135  -26.240 -27.447 1.00 35.44  ? 613  THR A C   1 
ATOM   2459 O  O   . THR A 1 350 ? -7.090  -25.889 -28.030 1.00 38.10  ? 613  THR A O   1 
ATOM   2460 C  CB  . THR A 1 350 ? -9.292  -24.654 -25.787 1.00 33.51  ? 613  THR A CB  1 
ATOM   2461 O  OG1 . THR A 1 350 ? -10.274 -23.623 -25.694 1.00 34.09  ? 613  THR A OG1 1 
ATOM   2462 C  CG2 . THR A 1 350 ? -7.958  -24.091 -25.347 1.00 35.64  ? 613  THR A CG2 1 
ATOM   2463 N  N   . ASN A 1 351 ? -8.393  -27.507 -27.101 1.00 32.01  ? 614  ASN A N   1 
ATOM   2464 C  CA  . ASN A 1 351 ? -7.462  -28.628 -27.380 1.00 31.84  ? 614  ASN A CA  1 
ATOM   2465 C  C   . ASN A 1 351 ? -7.258  -28.755 -28.894 1.00 28.24  ? 614  ASN A C   1 
ATOM   2466 O  O   . ASN A 1 351 ? -6.119  -28.874 -29.315 1.00 24.99  ? 614  ASN A O   1 
ATOM   2467 C  CB  . ASN A 1 351 ? -7.895  -29.937 -26.729 1.00 28.53  ? 614  ASN A CB  1 
ATOM   2468 C  CG  . ASN A 1 351 ? -6.724  -30.839 -26.394 1.00 29.77  ? 614  ASN A CG  1 
ATOM   2469 O  OD1 . ASN A 1 351 ? -5.553  -30.455 -26.547 1.00 26.93  ? 614  ASN A OD1 1 
ATOM   2470 N  ND2 . ASN A 1 351 ? -7.028  -32.035 -25.914 1.00 29.52  ? 614  ASN A ND2 1 
ATOM   2471 N  N   . MET A 1 352 ? -8.315  -28.689 -29.682 1.00 26.44  ? 615  MET A N   1 
ATOM   2472 C  CA  . MET A 1 352 ? -8.179  -28.788 -31.159 1.00 30.27  ? 615  MET A CA  1 
ATOM   2473 C  C   . MET A 1 352 ? -7.279  -27.619 -31.655 1.00 32.07  ? 615  MET A C   1 
ATOM   2474 O  O   . MET A 1 352 ? -6.417  -27.822 -32.543 1.00 32.69  ? 615  MET A O   1 
ATOM   2475 C  CB  . MET A 1 352 ? -9.551  -28.700 -31.852 1.00 29.11  ? 615  MET A CB  1 
ATOM   2476 C  CG  . MET A 1 352 ? -10.410 -29.945 -31.809 1.00 28.05  ? 615  MET A CG  1 
ATOM   2477 S  SD  . MET A 1 352 ? -12.105 -29.661 -32.503 1.00 30.29  ? 615  MET A SD  1 
ATOM   2478 C  CE  . MET A 1 352 ? -11.770 -29.398 -34.230 1.00 27.99  ? 615  MET A CE  1 
ATOM   2479 N  N   . GLU A 1 353 ? -7.475  -26.427 -31.107 1.00 32.22  ? 616  GLU A N   1 
ATOM   2480 C  CA  . GLU A 1 353 ? -6.734  -25.188 -31.481 1.00 34.12  ? 616  GLU A CA  1 
ATOM   2481 C  C   . GLU A 1 353 ? -5.240  -25.398 -31.150 1.00 33.03  ? 616  GLU A C   1 
ATOM   2482 O  O   . GLU A 1 353 ? -4.350  -25.216 -32.021 1.00 30.27  ? 616  GLU A O   1 
ATOM   2483 C  CB  . GLU A 1 353 ? -7.330  -24.025 -30.682 1.00 32.27  ? 616  GLU A CB  1 
ATOM   2484 C  CG  . GLU A 1 353 ? -6.689  -22.646 -30.920 1.00 35.28  ? 616  GLU A CG  1 
ATOM   2485 C  CD  . GLU A 1 353 ? -7.025  -21.664 -29.804 1.00 38.73  ? 616  GLU A CD  1 
ATOM   2486 O  OE1 . GLU A 1 353 ? -8.240  -21.298 -29.670 1.00 37.10  ? 616  GLU A OE1 1 
ATOM   2487 O  OE2 . GLU A 1 353 ? -6.110  -21.367 -28.989 1.00 34.37  ? 616  GLU A OE2 1 
ATOM   2488 N  N   . ALA A 1 354 ? -4.966  -25.731 -29.904 1.00 29.45  ? 617  ALA A N   1 
ATOM   2489 C  CA  . ALA A 1 354 ? -3.605  -26.031 -29.417 1.00 30.06  ? 617  ALA A CA  1 
ATOM   2490 C  C   . ALA A 1 354 ? -2.903  -27.095 -30.267 1.00 29.70  ? 617  ALA A C   1 
ATOM   2491 O  O   . ALA A 1 354 ? -1.701  -26.885 -30.559 1.00 29.89  ? 617  ALA A O   1 
ATOM   2492 C  CB  . ALA A 1 354 ? -3.691  -26.436 -27.986 1.00 29.18  ? 617  ALA A CB  1 
ATOM   2493 N  N   . GLN A 1 355 ? -3.564  -28.211 -30.599 1.00 26.93  ? 618  GLN A N   1 
ATOM   2494 C  CA  . GLN A 1 355 ? -2.905  -29.278 -31.381 1.00 27.20  ? 618  GLN A CA  1 
ATOM   2495 C  C   . GLN A 1 355 ? -2.646  -28.809 -32.824 1.00 27.22  ? 618  GLN A C   1 
ATOM   2496 O  O   . GLN A 1 355 ? -1.642  -29.314 -33.402 1.00 30.32  ? 618  GLN A O   1 
ATOM   2497 C  CB  . GLN A 1 355 ? -3.622  -30.634 -31.313 1.00 25.62  ? 618  GLN A CB  1 
ATOM   2498 C  CG  . GLN A 1 355 ? -3.841  -31.149 -29.897 1.00 26.80  ? 618  GLN A CG  1 
ATOM   2499 C  CD  . GLN A 1 355 ? -2.550  -31.253 -29.131 1.00 30.06  ? 618  GLN A CD  1 
ATOM   2500 O  OE1 . GLN A 1 355 ? -1.528  -31.700 -29.636 1.00 29.82  ? 618  GLN A OE1 1 
ATOM   2501 N  NE2 . GLN A 1 355 ? -2.613  -30.885 -27.875 1.00 29.76  ? 618  GLN A NE2 1 
ATOM   2502 N  N   . LEU A 1 356 ? -3.504  -27.993 -33.439 1.00 27.20  ? 619  LEU A N   1 
ATOM   2503 C  CA  . LEU A 1 356 ? -3.251  -27.474 -34.837 1.00 30.62  ? 619  LEU A CA  1 
ATOM   2504 C  C   . LEU A 1 356 ? -2.013  -26.558 -34.783 1.00 29.61  ? 619  LEU A C   1 
ATOM   2505 O  O   . LEU A 1 356 ? -1.195  -26.599 -35.703 1.00 33.51  ? 619  LEU A O   1 
ATOM   2506 C  CB  . LEU A 1 356 ? -4.431  -26.648 -35.374 1.00 30.58  ? 619  LEU A CB  1 
ATOM   2507 C  CG  . LEU A 1 356 ? -5.562  -27.355 -36.095 1.00 34.60  ? 619  LEU A CG  1 
ATOM   2508 C  CD1 . LEU A 1 356 ? -6.660  -26.346 -36.376 1.00 39.41  ? 619  LEU A CD1 1 
ATOM   2509 C  CD2 . LEU A 1 356 ? -5.112  -28.028 -37.382 1.00 37.83  ? 619  LEU A CD2 1 
ATOM   2510 N  N   . ILE A 1 357 ? -1.882  -25.752 -33.733 1.00 29.42  ? 620  ILE A N   1 
ATOM   2511 C  CA  . ILE A 1 357 ? -0.718  -24.831 -33.585 1.00 32.47  ? 620  ILE A CA  1 
ATOM   2512 C  C   . ILE A 1 357 ? 0.552   -25.664 -33.367 1.00 37.03  ? 620  ILE A C   1 
ATOM   2513 O  O   . ILE A 1 357 ? 1.571   -25.331 -33.995 1.00 31.50  ? 620  ILE A O   1 
ATOM   2514 C  CB  . ILE A 1 357 ? -0.977  -23.781 -32.493 1.00 32.89  ? 620  ILE A CB  1 
ATOM   2515 C  CG1 . ILE A 1 357 ? -2.136  -22.854 -32.904 1.00 32.75  ? 620  ILE A CG1 1 
ATOM   2516 C  CG2 . ILE A 1 357 ? 0.300   -23.020 -32.167 1.00 35.52  ? 620  ILE A CG2 1 
ATOM   2517 C  CD1 . ILE A 1 357 ? -2.751  -22.036 -31.781 1.00 34.02  ? 620  ILE A CD1 1 
ATOM   2518 N  N   . ARG A 1 358 ? 0.508   -26.737 -32.568 1.00 34.31  ? 621  ARG A N   1 
ATOM   2519 C  CA  . ARG A 1 358 ? 1.698   -27.602 -32.407 1.00 30.54  ? 621  ARG A CA  1 
ATOM   2520 C  C   . ARG A 1 358 ? 2.072   -28.246 -33.742 1.00 31.37  ? 621  ARG A C   1 
ATOM   2521 O  O   . ARG A 1 358 ? 3.303   -28.435 -33.977 1.00 29.91  ? 621  ARG A O   1 
ATOM   2522 C  CB  . ARG A 1 358 ? 1.504   -28.699 -31.373 1.00 29.35  ? 621  ARG A CB  1 
ATOM   2523 C  CG  . ARG A 1 358 ? 2.786   -29.442 -31.058 1.00 28.13  ? 621  ARG A CG  1 
ATOM   2524 C  CD  . ARG A 1 358 ? 2.614   -30.388 -29.879 1.00 29.36  ? 621  ARG A CD  1 
ATOM   2525 N  NE  . ARG A 1 358 ? 3.763   -31.275 -29.766 1.00 29.75  ? 621  ARG A NE  1 
ATOM   2526 C  CZ  . ARG A 1 358 ? 3.954   -32.257 -28.877 1.00 30.46  ? 621  ARG A CZ  1 
ATOM   2527 N  NH1 . ARG A 1 358 ? 3.041   -32.626 -27.987 1.00 29.38  ? 621  ARG A NH1 1 
ATOM   2528 N  NH2 . ARG A 1 358 ? 5.106   -32.895 -28.922 1.00 32.96  ? 621  ARG A NH2 1 
ATOM   2529 N  N   . GLN A 1 359 ? 1.088   -28.700 -34.516 1.00 28.35  ? 622  GLN A N   1 
ATOM   2530 C  CA  . GLN A 1 359 ? 1.358   -29.217 -35.880 1.00 30.49  ? 622  GLN A CA  1 
ATOM   2531 C  C   . GLN A 1 359 ? 1.986   -28.080 -36.737 1.00 33.91  ? 622  GLN A C   1 
ATOM   2532 O  O   . GLN A 1 359 ? 2.844   -28.392 -37.631 1.00 40.35  ? 622  GLN A O   1 
ATOM   2533 C  CB  . GLN A 1 359 ? 0.102   -29.766 -36.572 1.00 28.60  ? 622  GLN A CB  1 
ATOM   2534 C  CG  . GLN A 1 359 ? -0.475  -31.062 -36.026 1.00 30.77  ? 622  GLN A CG  1 
ATOM   2535 C  CD  . GLN A 1 359 ? -1.470  -31.701 -36.963 1.00 29.42  ? 622  GLN A CD  1 
ATOM   2536 O  OE1 . GLN A 1 359 ? -1.110  -32.253 -37.992 1.00 32.73  ? 622  GLN A OE1 1 
ATOM   2537 N  NE2 . GLN A 1 359 ? -2.734  -31.713 -36.570 1.00 30.19  ? 622  GLN A NE2 1 
ATOM   2538 N  N   . MET A 1 360 ? 1.543   -26.830 -36.591 1.00 35.38  ? 623  MET A N   1 
ATOM   2539 C  CA  . MET A 1 360 ? 2.116   -25.672 -37.359 1.00 39.02  ? 623  MET A CA  1 
ATOM   2540 C  C   . MET A 1 360 ? 3.622   -25.538 -37.005 1.00 35.55  ? 623  MET A C   1 
ATOM   2541 O  O   . MET A 1 360 ? 4.443   -25.565 -37.944 1.00 34.34  ? 623  MET A O   1 
ATOM   2542 C  CB  . MET A 1 360 ? 1.382   -24.366 -37.040 1.00 39.46  ? 623  MET A CB  1 
ATOM   2543 C  CG  . MET A 1 360 ? 0.144   -24.068 -37.906 1.00 43.95  ? 623  MET A CG  1 
ATOM   2544 S  SD  . MET A 1 360 ? -0.692  -22.694 -37.100 1.00 39.69  ? 623  MET A SD  1 
ATOM   2545 C  CE  . MET A 1 360 ? -2.389  -22.934 -37.619 1.00 47.15  ? 623  MET A CE  1 
ATOM   2546 N  N   . GLU A 1 361 ? 3.951   -25.551 -35.708 1.00 34.15  ? 624  GLU A N   1 
ATOM   2547 C  CA  . GLU A 1 361 ? 5.326   -25.451 -35.160 1.00 37.15  ? 624  GLU A CA  1 
ATOM   2548 C  C   . GLU A 1 361 ? 6.162   -26.590 -35.721 1.00 41.64  ? 624  GLU A C   1 
ATOM   2549 O  O   . GLU A 1 361 ? 7.253   -26.300 -36.181 1.00 40.28  ? 624  GLU A O   1 
ATOM   2550 C  CB  . GLU A 1 361 ? 5.343   -25.465 -33.630 1.00 36.55  ? 624  GLU A CB  1 
ATOM   2551 C  CG  . GLU A 1 361 ? 6.715   -25.138 -33.033 1.00 38.13  ? 624  GLU A CG  1 
ATOM   2552 C  CD  . GLU A 1 361 ? 6.719   -24.790 -31.542 1.00 42.24  ? 624  GLU A CD  1 
ATOM   2553 O  OE1 . GLU A 1 361 ? 7.817   -24.666 -30.962 1.00 41.17  ? 624  GLU A OE1 1 
ATOM   2554 O  OE2 . GLU A 1 361 ? 5.616   -24.591 -30.938 1.00 38.92  ? 624  GLU A OE2 1 
ATOM   2555 N  N   . GLY A 1 362 ? 5.658   -27.827 -35.712 1.00 37.23  ? 625  GLY A N   1 
ATOM   2556 C  CA  . GLY A 1 362 ? 6.371   -28.986 -36.279 1.00 37.87  ? 625  GLY A CA  1 
ATOM   2557 C  C   . GLY A 1 362 ? 6.675   -28.825 -37.772 1.00 41.16  ? 625  GLY A C   1 
ATOM   2558 O  O   . GLY A 1 362 ? 7.741   -29.315 -38.229 1.00 38.51  ? 625  GLY A O   1 
ATOM   2559 N  N   . GLU A 1 363 ? 5.731   -28.286 -38.543 1.00 35.35  ? 626  GLU A N   1 
ATOM   2560 C  CA  . GLU A 1 363 ? 5.889   -28.088 -40.003 1.00 37.72  ? 626  GLU A CA  1 
ATOM   2561 C  C   . GLU A 1 363 ? 6.662   -26.773 -40.253 1.00 39.74  ? 626  GLU A C   1 
ATOM   2562 O  O   . GLU A 1 363 ? 6.844   -26.418 -41.376 1.00 36.93  ? 626  GLU A O   1 
ATOM   2563 C  CB  . GLU A 1 363 ? 4.517   -28.092 -40.686 1.00 39.39  ? 626  GLU A CB  1 
ATOM   2564 C  CG  . GLU A 1 363 ? 3.848   -29.471 -40.696 1.00 39.24  ? 626  GLU A CG  1 
ATOM   2565 C  CD  . GLU A 1 363 ? 2.435   -29.541 -41.261 1.00 41.04  ? 626  GLU A CD  1 
ATOM   2566 O  OE1 . GLU A 1 363 ? 2.232   -28.943 -42.321 1.00 38.87  ? 626  GLU A OE1 1 
ATOM   2567 O  OE2 . GLU A 1 363 ? 1.520   -30.217 -40.641 1.00 38.13  ? 626  GLU A OE2 1 
ATOM   2568 N  N   . GLY A 1 364 ? 7.055   -26.021 -39.234 1.00 43.23  ? 627  GLY A N   1 
ATOM   2569 C  CA  . GLY A 1 364 ? 7.765   -24.746 -39.462 1.00 48.85  ? 627  GLY A CA  1 
ATOM   2570 C  C   . GLY A 1 364 ? 6.961   -23.729 -40.273 1.00 56.70  ? 627  GLY A C   1 
ATOM   2571 O  O   . GLY A 1 364 ? 7.582   -23.067 -41.154 1.00 50.06  ? 627  GLY A O   1 
ATOM   2572 N  N   . VAL A 1 365 ? 5.679   -23.527 -39.948 1.00 47.37  ? 628  VAL A N   1 
ATOM   2573 C  CA  . VAL A 1 365 ? 4.864   -22.458 -40.598 1.00 45.31  ? 628  VAL A CA  1 
ATOM   2574 C  C   . VAL A 1 365 ? 5.255   -21.135 -39.934 1.00 46.62  ? 628  VAL A C   1 
ATOM   2575 O  O   . VAL A 1 365 ? 5.134   -20.098 -40.595 1.00 48.45  ? 628  VAL A O   1 
ATOM   2576 C  CB  . VAL A 1 365 ? 3.355   -22.743 -40.470 1.00 46.52  ? 628  VAL A CB  1 
ATOM   2577 C  CG1 . VAL A 1 365 ? 2.504   -21.624 -41.044 1.00 47.37  ? 628  VAL A CG1 1 
ATOM   2578 C  CG2 . VAL A 1 365 ? 2.974   -24.080 -41.080 1.00 46.12  ? 628  VAL A CG2 1 
ATOM   2579 N  N   . PHE A 1 366 ? 5.694   -21.184 -38.677 1.00 44.58  ? 629  PHE A N   1 
ATOM   2580 C  CA  . PHE A 1 366 ? 6.178   -19.984 -37.947 1.00 47.94  ? 629  PHE A CA  1 
ATOM   2581 C  C   . PHE A 1 366 ? 7.497   -20.345 -37.258 1.00 51.87  ? 629  PHE A C   1 
ATOM   2582 O  O   . PHE A 1 366 ? 7.717   -21.531 -37.003 1.00 53.63  ? 629  PHE A O   1 
ATOM   2583 C  CB  . PHE A 1 366 ? 5.142   -19.485 -36.938 1.00 45.27  ? 629  PHE A CB  1 
ATOM   2584 C  CG  . PHE A 1 366 ? 4.918   -20.362 -35.734 1.00 47.79  ? 629  PHE A CG  1 
ATOM   2585 C  CD1 . PHE A 1 366 ? 3.962   -21.362 -35.753 1.00 48.98  ? 629  PHE A CD1 1 
ATOM   2586 C  CD2 . PHE A 1 366 ? 5.645   -20.170 -34.571 1.00 47.62  ? 629  PHE A CD2 1 
ATOM   2587 C  CE1 . PHE A 1 366 ? 3.748   -22.161 -34.642 1.00 44.94  ? 629  PHE A CE1 1 
ATOM   2588 C  CE2 . PHE A 1 366 ? 5.431   -20.970 -33.461 1.00 50.10  ? 629  PHE A CE2 1 
ATOM   2589 C  CZ  . PHE A 1 366 ? 4.483   -21.963 -33.499 1.00 46.44  ? 629  PHE A CZ  1 
ATOM   2590 N  N   . LYS A 1 367 ? 8.340   -19.355 -36.962 1.00 54.22  ? 630  LYS A N   1 
ATOM   2591 C  CA  . LYS A 1 367 ? 9.677   -19.660 -36.389 1.00 53.48  ? 630  LYS A CA  1 
ATOM   2592 C  C   . LYS A 1 367 ? 9.761   -19.229 -34.918 1.00 50.10  ? 630  LYS A C   1 
ATOM   2593 O  O   . LYS A 1 367 ? 10.532  -19.857 -34.188 1.00 51.07  ? 630  LYS A O   1 
ATOM   2594 C  CB  . LYS A 1 367 ? 10.768  -19.008 -37.242 1.00 66.35  ? 630  LYS A CB  1 
ATOM   2595 C  CG  . LYS A 1 367 ? 12.188  -19.473 -36.950 1.00 76.94  ? 630  LYS A CG  1 
ATOM   2596 C  CD  . LYS A 1 367 ? 13.252  -18.698 -37.699 1.00 81.38  ? 630  LYS A CD  1 
ATOM   2597 C  CE  . LYS A 1 367 ? 14.070  -17.788 -36.807 1.00 86.70  ? 630  LYS A CE  1 
ATOM   2598 N  NZ  . LYS A 1 367 ? 13.253  -16.706 -36.210 1.00 89.42  ? 630  LYS A NZ  1 
ATOM   2599 N  N   . SER A 1 368 ? 9.005   -18.213 -34.502 0.35 48.50  ? 631  SER A N   1 
ATOM   2600 C  CA  . SER A 1 368 ? 9.148   -17.723 -33.106 0.35 48.33  ? 631  SER A CA  1 
ATOM   2601 C  C   . SER A 1 368 ? 7.790   -17.392 -32.485 0.35 49.65  ? 631  SER A C   1 
ATOM   2602 O  O   . SER A 1 368 ? 6.978   -16.734 -33.157 0.35 50.69  ? 631  SER A O   1 
ATOM   2603 C  CB  . SER A 1 368 ? 10.062  -16.534 -33.044 0.35 48.43  ? 631  SER A CB  1 
ATOM   2604 O  OG  . SER A 1 368 ? 10.113  -16.012 -31.725 0.35 44.97  ? 631  SER A OG  1 
ATOM   2605 N  N   . ILE A 1 369 ? 7.578   -17.812 -31.236 0.35 50.57  ? 632  ILE A N   1 
ATOM   2606 C  CA  . ILE A 1 369 ? 6.312   -17.498 -30.513 0.35 53.32  ? 632  ILE A CA  1 
ATOM   2607 C  C   . ILE A 1 369 ? 6.423   -16.083 -29.942 0.35 55.39  ? 632  ILE A C   1 
ATOM   2608 O  O   . ILE A 1 369 ? 5.399   -15.547 -29.492 0.35 54.13  ? 632  ILE A O   1 
ATOM   2609 C  CB  . ILE A 1 369 ? 6.061   -18.532 -29.400 0.35 51.34  ? 632  ILE A CB  1 
ATOM   2610 C  CG1 . ILE A 1 369 ? 7.121   -18.447 -28.300 0.35 50.60  ? 632  ILE A CG1 1 
ATOM   2611 C  CG2 . ILE A 1 369 ? 5.958   -19.933 -29.981 0.35 53.78  ? 632  ILE A CG2 1 
ATOM   2612 C  CD1 . ILE A 1 369 ? 6.869   -19.372 -27.135 0.35 51.17  ? 632  ILE A CD1 1 
ATOM   2613 N  N   . GLN A 1 370 ? 7.623   -15.498 -29.966 1.00 59.18  ? 633  GLN A N   1 
ATOM   2614 C  CA  . GLN A 1 370 ? 7.842   -14.151 -29.370 1.00 61.15  ? 633  GLN A CA  1 
ATOM   2615 C  C   . GLN A 1 370 ? 7.113   -13.095 -30.199 1.00 62.32  ? 633  GLN A C   1 
ATOM   2616 O  O   . GLN A 1 370 ? 6.524   -12.187 -29.600 1.00 53.40  ? 633  GLN A O   1 
ATOM   2617 C  CB  . GLN A 1 370 ? 9.333   -13.836 -29.312 1.00 62.41  ? 633  GLN A CB  1 
ATOM   2618 C  CG  . GLN A 1 370 ? 9.731   -13.022 -28.092 1.00 72.56  ? 633  GLN A CG  1 
ATOM   2619 C  CD  . GLN A 1 370 ? 10.035  -13.898 -26.904 1.00 70.70  ? 633  GLN A CD  1 
ATOM   2620 O  OE1 . GLN A 1 370 ? 10.270  -15.096 -27.038 1.00 67.98  ? 633  GLN A OE1 1 
ATOM   2621 N  NE2 . GLN A 1 370 ? 10.046  -13.299 -25.725 1.00 73.82  ? 633  GLN A NE2 1 
ATOM   2622 N  N   . HIS A 1 371 ? 7.169   -13.222 -31.527 0.35 61.72  ? 634  HIS A N   1 
ATOM   2623 C  CA  . HIS A 1 371 ? 6.500   -12.247 -32.425 0.35 64.36  ? 634  HIS A CA  1 
ATOM   2624 C  C   . HIS A 1 371 ? 6.248   -12.881 -33.793 0.35 62.96  ? 634  HIS A C   1 
ATOM   2625 O  O   . HIS A 1 371 ? 7.155   -13.560 -34.305 0.35 60.60  ? 634  HIS A O   1 
ATOM   2626 C  CB  . HIS A 1 371 ? 7.343   -10.974 -32.558 0.35 68.02  ? 634  HIS A CB  1 
ATOM   2627 C  CG  . HIS A 1 371 ? 7.144   -10.268 -33.857 0.35 71.17  ? 634  HIS A CG  1 
ATOM   2628 N  ND1 . HIS A 1 371 ? 7.988   -10.455 -34.933 0.35 75.36  ? 634  HIS A ND1 1 
ATOM   2629 C  CD2 . HIS A 1 371 ? 6.199   -9.394  -34.263 0.35 72.57  ? 634  HIS A CD2 1 
ATOM   2630 C  CE1 . HIS A 1 371 ? 7.576   -9.720  -35.946 0.35 75.19  ? 634  HIS A CE1 1 
ATOM   2631 N  NE2 . HIS A 1 371 ? 6.480   -9.059  -35.560 0.35 73.69  ? 634  HIS A NE2 1 
ATOM   2632 N  N   . LEU A 1 372 ? 5.067   -12.642 -34.364 0.35 64.20  ? 635  LEU A N   1 
ATOM   2633 C  CA  . LEU A 1 372 ? 4.754   -13.168 -35.716 0.35 65.22  ? 635  LEU A CA  1 
ATOM   2634 C  C   . LEU A 1 372 ? 4.886   -12.032 -36.733 0.35 64.68  ? 635  LEU A C   1 
ATOM   2635 O  O   . LEU A 1 372 ? 4.280   -10.972 -36.512 0.35 67.03  ? 635  LEU A O   1 
ATOM   2636 C  CB  . LEU A 1 372 ? 3.333   -13.739 -35.722 0.35 66.23  ? 635  LEU A CB  1 
ATOM   2637 C  CG  . LEU A 1 372 ? 3.213   -15.203 -36.142 0.35 66.12  ? 635  LEU A CG  1 
ATOM   2638 C  CD1 . LEU A 1 372 ? 3.831   -16.115 -35.094 0.35 67.16  ? 635  LEU A CD1 1 
ATOM   2639 C  CD2 . LEU A 1 372 ? 1.759   -15.577 -36.379 0.35 66.43  ? 635  LEU A CD2 1 
ATOM   2640 N  N   . THR A 1 373 ? 5.644   -12.262 -37.805 0.35 64.60  ? 636  THR A N   1 
ATOM   2641 C  CA  . THR A 1 373 ? 5.792   -11.246 -38.874 0.35 66.11  ? 636  THR A CA  1 
ATOM   2642 C  C   . THR A 1 373 ? 4.467   -11.110 -39.622 0.35 65.96  ? 636  THR A C   1 
ATOM   2643 O  O   . THR A 1 373 ? 3.643   -12.037 -39.531 0.35 66.13  ? 636  THR A O   1 
ATOM   2644 C  CB  . THR A 1 373 ? 6.909   -11.641 -39.844 0.35 66.17  ? 636  THR A CB  1 
ATOM   2645 O  OG1 . THR A 1 373 ? 6.410   -12.662 -40.707 0.35 66.70  ? 636  THR A OG1 1 
ATOM   2646 C  CG2 . THR A 1 373 ? 8.153   -12.127 -39.135 0.35 66.28  ? 636  THR A CG2 1 
ATOM   2647 N  N   . VAL A 1 374 ? 4.276   -9.998  -40.331 0.35 67.01  ? 637  VAL A N   1 
ATOM   2648 C  CA  . VAL A 1 374 ? 3.045   -9.822  -41.152 0.35 67.37  ? 637  VAL A CA  1 
ATOM   2649 C  C   . VAL A 1 374 ? 2.921   -11.020 -42.096 0.35 66.07  ? 637  VAL A C   1 
ATOM   2650 O  O   . VAL A 1 374 ? 1.794   -11.524 -42.259 0.35 66.91  ? 637  VAL A O   1 
ATOM   2651 C  CB  . VAL A 1 374 ? 3.073   -8.494  -41.931 0.35 69.59  ? 637  VAL A CB  1 
ATOM   2652 C  CG1 . VAL A 1 374 ? 2.894   -7.299  -41.010 0.35 71.01  ? 637  VAL A CG1 1 
ATOM   2653 C  CG2 . VAL A 1 374 ? 4.340   -8.350  -42.760 0.35 69.95  ? 637  VAL A CG2 1 
ATOM   2654 N  N   . THR A 1 375 ? 4.036   -11.463 -42.680 0.35 63.40  ? 638  THR A N   1 
ATOM   2655 C  CA  . THR A 1 375 ? 3.959   -12.568 -43.674 0.35 64.22  ? 638  THR A CA  1 
ATOM   2656 C  C   . THR A 1 375 ? 3.924   -13.935 -42.965 0.35 62.49  ? 638  THR A C   1 
ATOM   2657 O  O   . THR A 1 375 ? 3.773   -14.953 -43.675 0.35 59.28  ? 638  THR A O   1 
ATOM   2658 C  CB  . THR A 1 375 ? 5.101   -12.467 -44.694 0.35 65.33  ? 638  THR A CB  1 
ATOM   2659 O  OG1 . THR A 1 375 ? 6.321   -12.355 -43.962 0.35 69.27  ? 638  THR A OG1 1 
ATOM   2660 C  CG2 . THR A 1 375 ? 4.950   -11.292 -45.637 0.35 66.15  ? 638  THR A CG2 1 
ATOM   2661 N  N   . GLU A 1 376 ? 4.058   -13.970 -41.631 0.35 60.82  ? 639  GLU A N   1 
ATOM   2662 C  CA  . GLU A 1 376 ? 3.902   -15.201 -40.803 0.35 59.52  ? 639  GLU A CA  1 
ATOM   2663 C  C   . GLU A 1 376 ? 2.466   -15.283 -40.264 0.35 58.23  ? 639  GLU A C   1 
ATOM   2664 O  O   . GLU A 1 376 ? 2.145   -16.297 -39.612 0.35 58.07  ? 639  GLU A O   1 
ATOM   2665 C  CB  . GLU A 1 376 ? 4.934   -15.249 -39.670 0.35 57.51  ? 639  GLU A CB  1 
ATOM   2666 C  CG  . GLU A 1 376 ? 6.268   -15.848 -40.096 0.35 54.94  ? 639  GLU A CG  1 
ATOM   2667 C  CD  . GLU A 1 376 ? 7.249   -16.149 -38.974 0.35 53.66  ? 639  GLU A CD  1 
ATOM   2668 O  OE1 . GLU A 1 376 ? 8.112   -17.024 -39.176 0.35 53.62  ? 639  GLU A OE1 1 
ATOM   2669 O  OE2 . GLU A 1 376 ? 7.156   -15.511 -37.906 0.35 51.09  ? 639  GLU A OE2 1 
ATOM   2670 N  N   . GLU A 1 377 ? 1.610   -14.342 -40.669 0.35 57.36  ? 640  GLU A N   1 
ATOM   2671 C  CA  . GLU A 1 377 ? 0.164   -14.431 -40.336 0.35 56.19  ? 640  GLU A CA  1 
ATOM   2672 C  C   . GLU A 1 377 ? -0.527  -14.859 -41.634 0.35 57.35  ? 640  GLU A C   1 
ATOM   2673 O  O   . GLU A 1 377 ? -1.395  -15.744 -41.571 0.35 60.00  ? 640  GLU A O   1 
ATOM   2674 C  CB  . GLU A 1 377 ? -0.341  -13.091 -39.807 0.35 55.08  ? 640  GLU A CB  1 
ATOM   2675 C  CG  . GLU A 1 377 ? 0.410   -12.614 -38.578 0.35 56.95  ? 640  GLU A CG  1 
ATOM   2676 C  CD  . GLU A 1 377 ? -0.129  -11.340 -37.952 0.35 56.76  ? 640  GLU A CD  1 
ATOM   2677 O  OE1 . GLU A 1 377 ? -1.213  -10.892 -38.371 0.35 54.37  ? 640  GLU A OE1 1 
ATOM   2678 O  OE2 . GLU A 1 377 ? 0.538   -10.798 -37.050 0.35 58.81  ? 640  GLU A OE2 1 
ATOM   2679 N  N   . ILE A 1 378 ? -0.139  -14.263 -42.764 0.35 57.77  ? 641  ILE A N   1 
ATOM   2680 C  CA  . ILE A 1 378 ? -0.661  -14.650 -44.110 0.35 58.35  ? 641  ILE A CA  1 
ATOM   2681 C  C   . ILE A 1 378 ? -0.369  -16.141 -44.345 0.35 58.32  ? 641  ILE A C   1 
ATOM   2682 O  O   . ILE A 1 378 ? -1.246  -16.822 -44.912 0.35 60.19  ? 641  ILE A O   1 
ATOM   2683 C  CB  . ILE A 1 378 ? -0.079  -13.734 -45.213 0.35 56.19  ? 641  ILE A CB  1 
ATOM   2684 C  CG1 . ILE A 1 378 ? -0.912  -13.749 -46.502 0.35 56.23  ? 641  ILE A CG1 1 
ATOM   2685 C  CG2 . ILE A 1 378 ? 1.387   -14.046 -45.468 0.35 55.69  ? 641  ILE A CG2 1 
ATOM   2686 C  CD1 . ILE A 1 378 ? -0.472  -14.751 -47.548 0.35 55.64  ? 641  ILE A CD1 1 
ATOM   2687 N  N   . ALA A 1 379 ? 0.802   -16.634 -43.920 1.00 58.31  ? 642  ALA A N   1 
ATOM   2688 C  CA  . ALA A 1 379 ? 1.190   -18.054 -44.122 1.00 55.06  ? 642  ALA A CA  1 
ATOM   2689 C  C   . ALA A 1 379 ? 0.396   -19.000 -43.175 1.00 48.70  ? 642  ALA A C   1 
ATOM   2690 O  O   . ALA A 1 379 ? -0.047  -20.042 -43.659 1.00 40.00  ? 642  ALA A O   1 
ATOM   2691 C  CB  . ALA A 1 379 ? 2.691   -18.193 -43.970 1.00 48.22  ? 642  ALA A CB  1 
ATOM   2692 N  N   . VAL A 1 380 ? 0.207   -18.633 -41.900 1.00 37.51  ? 643  VAL A N   1 
ATOM   2693 C  CA  . VAL A 1 380 ? -0.625  -19.371 -40.914 1.00 46.64  ? 643  VAL A CA  1 
ATOM   2694 C  C   . VAL A 1 380 ? -2.045  -19.488 -41.488 1.00 51.29  ? 643  VAL A C   1 
ATOM   2695 O  O   . VAL A 1 380 ? -2.610  -20.626 -41.535 1.00 44.17  ? 643  VAL A O   1 
ATOM   2696 C  CB  . VAL A 1 380 ? -0.553  -18.718 -39.521 1.00 46.52  ? 643  VAL A CB  1 
ATOM   2697 C  CG1 . VAL A 1 380 ? -1.634  -19.211 -38.583 1.00 47.25  ? 643  VAL A CG1 1 
ATOM   2698 C  CG2 . VAL A 1 380 ? 0.804   -18.966 -38.885 1.00 47.50  ? 643  VAL A CG2 1 
ATOM   2699 N  N   . LYS A 1 381 ? -2.597  -18.356 -41.940 0.35 50.69  ? 644  LYS A N   1 
ATOM   2700 C  CA  . LYS A 1 381 ? -3.956  -18.252 -42.540 0.35 51.48  ? 644  LYS A CA  1 
ATOM   2701 C  C   . LYS A 1 381 ? -4.041  -19.132 -43.794 0.35 50.66  ? 644  LYS A C   1 
ATOM   2702 O  O   . LYS A 1 381 ? -5.036  -19.878 -43.921 0.35 48.31  ? 644  LYS A O   1 
ATOM   2703 C  CB  . LYS A 1 381 ? -4.295  -16.790 -42.850 0.35 54.32  ? 644  LYS A CB  1 
ATOM   2704 C  CG  . LYS A 1 381 ? -4.897  -16.016 -41.685 0.35 56.73  ? 644  LYS A CG  1 
ATOM   2705 C  CD  . LYS A 1 381 ? -4.456  -14.569 -41.616 0.35 59.14  ? 644  LYS A CD  1 
ATOM   2706 C  CE  . LYS A 1 381 ? -5.083  -13.817 -40.461 0.35 59.97  ? 644  LYS A CE  1 
ATOM   2707 N  NZ  . LYS A 1 381 ? -4.209  -12.715 -39.996 0.35 61.35  ? 644  LYS A NZ  1 
ATOM   2708 N  N   . ASN A 1 382 ? -3.038  -19.058 -44.676 0.35 48.83  ? 645  ASN A N   1 
ATOM   2709 C  CA  . ASN A 1 382 ? -2.971  -19.881 -45.914 0.35 50.49  ? 645  ASN A CA  1 
ATOM   2710 C  C   . ASN A 1 382 ? -2.943  -21.365 -45.532 0.35 47.98  ? 645  ASN A C   1 
ATOM   2711 O  O   . ASN A 1 382 ? -3.696  -22.142 -46.147 0.35 46.35  ? 645  ASN A O   1 
ATOM   2712 C  CB  . ASN A 1 382 ? -1.774  -19.521 -46.801 0.35 54.35  ? 645  ASN A CB  1 
ATOM   2713 C  CG  . ASN A 1 382 ? -2.165  -18.675 -47.994 0.35 58.41  ? 645  ASN A CG  1 
ATOM   2714 O  OD1 . ASN A 1 382 ? -2.665  -17.561 -47.837 0.35 61.85  ? 645  ASN A OD1 1 
ATOM   2715 N  ND2 . ASN A 1 382 ? -1.947  -19.198 -49.191 0.35 58.82  ? 645  ASN A ND2 1 
ATOM   2716 N  N   . TRP A 1 383 ? -2.114  -21.727 -44.548 1.00 47.00  ? 646  TRP A N   1 
ATOM   2717 C  CA  . TRP A 1 383 ? -2.005  -23.126 -44.040 1.00 42.24  ? 646  TRP A CA  1 
ATOM   2718 C  C   . TRP A 1 383 ? -3.408  -23.616 -43.629 1.00 33.18  ? 646  TRP A C   1 
ATOM   2719 O  O   . TRP A 1 383 ? -3.888  -24.571 -44.217 1.00 31.67  ? 646  TRP A O   1 
ATOM   2720 C  CB  . TRP A 1 383 ? -0.978  -23.159 -42.901 1.00 37.67  ? 646  TRP A CB  1 
ATOM   2721 C  CG  . TRP A 1 383 ? -0.574  -24.521 -42.422 1.00 43.79  ? 646  TRP A CG  1 
ATOM   2722 C  CD1 . TRP A 1 383 ? 0.444   -25.320 -42.871 1.00 46.23  ? 646  TRP A CD1 1 
ATOM   2723 C  CD2 . TRP A 1 383 ? -1.175  -25.232 -41.331 1.00 40.23  ? 646  TRP A CD2 1 
ATOM   2724 N  NE1 . TRP A 1 383 ? 0.519   -26.470 -42.127 1.00 41.18  ? 646  TRP A NE1 1 
ATOM   2725 C  CE2 . TRP A 1 383 ? -0.450  -26.431 -41.164 1.00 41.72  ? 646  TRP A CE2 1 
ATOM   2726 C  CE3 . TRP A 1 383 ? -2.222  -24.941 -40.458 1.00 37.47  ? 646  TRP A CE3 1 
ATOM   2727 C  CZ2 . TRP A 1 383 ? -0.770  -27.346 -40.167 1.00 41.13  ? 646  TRP A CZ2 1 
ATOM   2728 C  CZ3 . TRP A 1 383 ? -2.529  -25.844 -39.464 1.00 40.08  ? 646  TRP A CZ3 1 
ATOM   2729 C  CH2 . TRP A 1 383 ? -1.793  -27.015 -39.306 1.00 38.92  ? 646  TRP A CH2 1 
ATOM   2730 N  N   . LEU A 1 384 ? -4.105  -22.869 -42.774 1.00 36.07  ? 647  LEU A N   1 
ATOM   2731 C  CA  . LEU A 1 384 ? -5.454  -23.252 -42.277 1.00 40.18  ? 647  LEU A CA  1 
ATOM   2732 C  C   . LEU A 1 384 ? -6.405  -23.476 -43.463 1.00 45.10  ? 647  LEU A C   1 
ATOM   2733 O  O   . LEU A 1 384 ? -7.087  -24.517 -43.489 1.00 43.72  ? 647  LEU A O   1 
ATOM   2734 C  CB  . LEU A 1 384 ? -5.957  -22.178 -41.317 1.00 38.00  ? 647  LEU A CB  1 
ATOM   2735 C  CG  . LEU A 1 384 ? -5.262  -22.170 -39.954 1.00 38.53  ? 647  LEU A CG  1 
ATOM   2736 C  CD1 . LEU A 1 384 ? -5.626  -20.934 -39.155 1.00 41.05  ? 647  LEU A CD1 1 
ATOM   2737 C  CD2 . LEU A 1 384 ? -5.592  -23.409 -39.137 1.00 41.46  ? 647  LEU A CD2 1 
ATOM   2738 N  N   . VAL A 1 385 ? -6.393  -22.575 -44.445 1.00 47.03  ? 648  VAL A N   1 
ATOM   2739 C  CA  . VAL A 1 385 ? -7.322  -22.589 -45.609 1.00 45.05  ? 648  VAL A CA  1 
ATOM   2740 C  C   . VAL A 1 385 ? -6.969  -23.762 -46.512 1.00 44.95  ? 648  VAL A C   1 
ATOM   2741 O  O   . VAL A 1 385 ? -7.876  -24.420 -47.042 1.00 50.68  ? 648  VAL A O   1 
ATOM   2742 C  CB  . VAL A 1 385 ? -7.253  -21.238 -46.373 1.00 53.57  ? 648  VAL A CB  1 
ATOM   2743 C  CG1 . VAL A 1 385 ? -7.801  -21.329 -47.786 1.00 51.69  ? 648  VAL A CG1 1 
ATOM   2744 C  CG2 . VAL A 1 385 ? -7.979  -20.129 -45.627 1.00 53.14  ? 648  VAL A CG2 1 
ATOM   2745 N  N   . ARG A 1 386 ? -5.667  -24.022 -46.650 0.35 46.09  ? 649  ARG A N   1 
ATOM   2746 C  CA  . ARG A 1 386 ? -5.077  -24.997 -47.604 0.35 47.29  ? 649  ARG A CA  1 
ATOM   2747 C  C   . ARG A 1 386 ? -5.150  -26.419 -47.020 0.35 46.93  ? 649  ARG A C   1 
ATOM   2748 O  O   . ARG A 1 386 ? -5.572  -27.336 -47.754 0.35 46.45  ? 649  ARG A O   1 
ATOM   2749 C  CB  . ARG A 1 386 ? -3.641  -24.550 -47.905 0.35 49.46  ? 649  ARG A CB  1 
ATOM   2750 C  CG  . ARG A 1 386 ? -3.016  -25.136 -49.163 0.35 50.61  ? 649  ARG A CG  1 
ATOM   2751 C  CD  . ARG A 1 386 ? -1.646  -24.525 -49.432 0.35 52.11  ? 649  ARG A CD  1 
ATOM   2752 N  NE  . ARG A 1 386 ? -0.591  -25.061 -48.567 0.35 52.74  ? 649  ARG A NE  1 
ATOM   2753 C  CZ  . ARG A 1 386 ? 0.076   -24.392 -47.620 0.35 51.32  ? 649  ARG A CZ  1 
ATOM   2754 N  NH1 . ARG A 1 386 ? -0.171  -23.115 -47.369 0.35 51.70  ? 649  ARG A NH1 1 
ATOM   2755 N  NH2 . ARG A 1 386 ? 1.008   -25.016 -46.920 0.35 50.41  ? 649  ARG A NH2 1 
ATOM   2756 N  N   . VAL A 1 387 ? -4.751  -26.599 -45.753 1.00 44.94  ? 650  VAL A N   1 
ATOM   2757 C  CA  . VAL A 1 387 ? -4.580  -27.968 -45.147 1.00 46.69  ? 650  VAL A CA  1 
ATOM   2758 C  C   . VAL A 1 387 ? -5.313  -28.156 -43.812 1.00 38.95  ? 650  VAL A C   1 
ATOM   2759 O  O   . VAL A 1 387 ? -5.242  -29.325 -43.323 1.00 39.83  ? 650  VAL A O   1 
ATOM   2760 C  CB  . VAL A 1 387 ? -3.091  -28.365 -44.999 1.00 38.52  ? 650  VAL A CB  1 
ATOM   2761 C  CG1 . VAL A 1 387 ? -2.413  -28.419 -46.356 1.00 38.80  ? 650  VAL A CG1 1 
ATOM   2762 C  CG2 . VAL A 1 387 ? -2.337  -27.472 -44.018 1.00 34.89  ? 650  VAL A CG2 1 
ATOM   2763 N  N   . GLY A 1 388 ? -5.977  -27.119 -43.283 1.00 33.61  ? 651  GLY A N   1 
ATOM   2764 C  CA  . GLY A 1 388 ? -6.563  -27.099 -41.920 1.00 37.62  ? 651  GLY A CA  1 
ATOM   2765 C  C   . GLY A 1 388 ? -7.462  -28.309 -41.691 1.00 37.51  ? 651  GLY A C   1 
ATOM   2766 O  O   . GLY A 1 388 ? -7.284  -29.044 -40.707 1.00 36.22  ? 651  GLY A O   1 
ATOM   2767 N  N   . ARG A 1 389 ? -8.354  -28.562 -42.628 1.00 37.83  ? 652  ARG A N   1 
ATOM   2768 C  CA  . ARG A 1 389 ? -9.343  -29.652 -42.527 1.00 39.54  ? 652  ARG A CA  1 
ATOM   2769 C  C   . ARG A 1 389 ? -8.565  -30.968 -42.566 1.00 38.52  ? 652  ARG A C   1 
ATOM   2770 O  O   . ARG A 1 389 ? -8.936  -31.874 -41.783 1.00 39.87  ? 652  ARG A O   1 
ATOM   2771 C  CB  . ARG A 1 389 ? -10.400 -29.572 -43.635 1.00 38.67  ? 652  ARG A CB  1 
ATOM   2772 C  CG  . ARG A 1 389 ? -11.393 -28.424 -43.488 1.00 41.62  ? 652  ARG A CG  1 
ATOM   2773 C  CD  . ARG A 1 389 ? -12.443 -28.468 -44.604 1.00 39.78  ? 652  ARG A CD  1 
ATOM   2774 N  NE  . ARG A 1 389 ? -13.444 -29.519 -44.444 1.00 38.95  ? 652  ARG A NE  1 
ATOM   2775 C  CZ  . ARG A 1 389 ? -14.424 -29.482 -43.527 1.00 40.88  ? 652  ARG A CZ  1 
ATOM   2776 N  NH1 . ARG A 1 389 ? -14.550 -28.463 -42.678 1.00 42.98  ? 652  ARG A NH1 1 
ATOM   2777 N  NH2 . ARG A 1 389 ? -15.277 -30.474 -43.454 1.00 38.99  ? 652  ARG A NH2 1 
ATOM   2778 N  N   . GLU A 1 390 ? -7.542  -31.092 -43.417 1.00 31.80  ? 653  GLU A N   1 
ATOM   2779 C  CA  . GLU A 1 390 ? -6.756  -32.357 -43.479 1.00 34.48  ? 653  GLU A CA  1 
ATOM   2780 C  C   . GLU A 1 390 ? -6.051  -32.580 -42.117 1.00 33.63  ? 653  GLU A C   1 
ATOM   2781 O  O   . GLU A 1 390 ? -6.117  -33.696 -41.591 1.00 35.33  ? 653  GLU A O   1 
ATOM   2782 C  CB  . GLU A 1 390 ? -5.762  -32.353 -44.636 1.00 36.27  ? 653  GLU A CB  1 
ATOM   2783 C  CG  . GLU A 1 390 ? -5.231  -33.728 -45.005 1.00 32.89  ? 653  GLU A CG  1 
ATOM   2784 C  CD  . GLU A 1 390 ? -4.127  -34.287 -44.111 1.00 35.95  ? 653  GLU A CD  1 
ATOM   2785 O  OE1 . GLU A 1 390 ? -3.508  -33.524 -43.300 1.00 31.96  ? 653  GLU A OE1 1 
ATOM   2786 O  OE2 . GLU A 1 390 ? -3.903  -35.503 -44.197 1.00 39.05  ? 653  GLU A OE2 1 
ATOM   2787 N  N   . ARG A 1 391 ? -5.555  -31.524 -41.483 1.00 31.15  ? 654  ARG A N   1 
ATOM   2788 C  CA  . ARG A 1 391 ? -4.796  -31.642 -40.241 1.00 32.63  ? 654  ARG A CA  1 
ATOM   2789 C  C   . ARG A 1 391 ? -5.773  -31.971 -39.111 1.00 31.02  ? 654  ARG A C   1 
ATOM   2790 O  O   . ARG A 1 391 ? -5.312  -32.618 -38.144 1.00 28.71  ? 654  ARG A O   1 
ATOM   2791 C  CB  . ARG A 1 391 ? -3.937  -30.396 -40.012 1.00 34.31  ? 654  ARG A CB  1 
ATOM   2792 C  CG  . ARG A 1 391 ? -2.952  -30.114 -41.143 1.00 36.19  ? 654  ARG A CG  1 
ATOM   2793 C  CD  . ARG A 1 391 ? -1.853  -31.148 -41.217 1.00 38.97  ? 654  ARG A CD  1 
ATOM   2794 N  NE  . ARG A 1 391 ? -0.772  -30.593 -42.014 1.00 40.92  ? 654  ARG A NE  1 
ATOM   2795 C  CZ  . ARG A 1 391 ? -0.635  -30.738 -43.325 1.00 41.54  ? 654  ARG A CZ  1 
ATOM   2796 N  NH1 . ARG A 1 391 ? -1.468  -31.478 -44.035 1.00 43.28  ? 654  ARG A NH1 1 
ATOM   2797 N  NH2 . ARG A 1 391 ? 0.389   -30.173 -43.929 1.00 47.34  ? 654  ARG A NH2 1 
ATOM   2798 N  N   . LEU A 1 392 ? -7.037  -31.532 -39.173 1.00 31.88  ? 655  LEU A N   1 
ATOM   2799 C  CA  . LEU A 1 392 ? -8.025  -31.844 -38.081 1.00 31.37  ? 655  LEU A CA  1 
ATOM   2800 C  C   . LEU A 1 392 ? -8.331  -33.339 -38.160 1.00 30.62  ? 655  LEU A C   1 
ATOM   2801 O  O   . LEU A 1 392 ? -8.437  -33.978 -37.112 1.00 28.49  ? 655  LEU A O   1 
ATOM   2802 C  CB  . LEU A 1 392 ? -9.307  -31.018 -38.177 1.00 32.04  ? 655  LEU A CB  1 
ATOM   2803 C  CG  . LEU A 1 392 ? -9.225  -29.530 -37.842 1.00 30.40  ? 655  LEU A CG  1 
ATOM   2804 C  CD1 . LEU A 1 392 ? -10.543 -28.871 -38.204 1.00 34.33  ? 655  LEU A CD1 1 
ATOM   2805 C  CD2 . LEU A 1 392 ? -8.884  -29.284 -36.391 1.00 27.66  ? 655  LEU A CD2 1 
ATOM   2806 N  N   . SER A 1 393 ? -8.357  -33.879 -39.373 1.00 29.75  ? 656  SER A N   1 
ATOM   2807 C  CA  . SER A 1 393 ? -8.696  -35.292 -39.626 1.00 32.00  ? 656  SER A CA  1 
ATOM   2808 C  C   . SER A 1 393 ? -7.591  -36.208 -39.129 1.00 31.56  ? 656  SER A C   1 
ATOM   2809 O  O   . SER A 1 393 ? -7.855  -37.369 -39.064 1.00 28.01  ? 656  SER A O   1 
ATOM   2810 C  CB  . SER A 1 393 ? -8.985  -35.549 -41.088 1.00 35.07  ? 656  SER A CB  1 
ATOM   2811 O  OG  . SER A 1 393 ? -7.803  -35.515 -41.873 1.00 40.31  ? 656  SER A OG  1 
ATOM   2812 N  N   . ARG A 1 394 ? -6.392  -35.689 -38.825 1.00 31.70  ? 657  ARG A N   1 
ATOM   2813 C  CA  . ARG A 1 394 ? -5.253  -36.480 -38.297 1.00 31.61  ? 657  ARG A CA  1 
ATOM   2814 C  C   . ARG A 1 394 ? -5.346  -36.571 -36.786 1.00 26.41  ? 657  ARG A C   1 
ATOM   2815 O  O   . ARG A 1 394 ? -4.354  -37.013 -36.150 1.00 27.30  ? 657  ARG A O   1 
ATOM   2816 C  CB  . ARG A 1 394 ? -3.926  -35.768 -38.562 1.00 34.22  ? 657  ARG A CB  1 
ATOM   2817 C  CG  . ARG A 1 394 ? -3.547  -35.739 -40.020 1.00 34.77  ? 657  ARG A CG  1 
ATOM   2818 C  CD  . ARG A 1 394 ? -2.285  -34.946 -40.246 1.00 33.87  ? 657  ARG A CD  1 
ATOM   2819 N  NE  . ARG A 1 394 ? -2.004  -35.364 -41.602 1.00 34.76  ? 657  ARG A NE  1 
ATOM   2820 C  CZ  . ARG A 1 394 ? -1.299  -36.417 -41.910 1.00 36.34  ? 657  ARG A CZ  1 
ATOM   2821 N  NH1 . ARG A 1 394 ? -0.711  -37.132 -40.961 1.00 35.62  ? 657  ARG A NH1 1 
ATOM   2822 N  NH2 . ARG A 1 394 ? -1.165  -36.752 -43.178 1.00 40.09  ? 657  ARG A NH2 1 
ATOM   2823 N  N   . MET A 1 395 ? -6.430  -36.093 -36.218 1.00 25.69  ? 658  MET A N   1 
ATOM   2824 C  CA  . MET A 1 395 ? -6.575  -36.093 -34.734 1.00 26.17  ? 658  MET A CA  1 
ATOM   2825 C  C   . MET A 1 395 ? -7.876  -36.767 -34.249 1.00 25.29  ? 658  MET A C   1 
ATOM   2826 O  O   . MET A 1 395 ? -8.894  -36.716 -34.900 1.00 25.35  ? 658  MET A O   1 
ATOM   2827 C  CB  . MET A 1 395 ? -6.486  -34.641 -34.269 1.00 27.80  ? 658  MET A CB  1 
ATOM   2828 C  CG  . MET A 1 395 ? -5.212  -33.909 -34.759 1.00 30.24  ? 658  MET A CG  1 
ATOM   2829 S  SD  . MET A 1 395 ? -4.879  -32.353 -33.837 1.00 29.80  ? 658  MET A SD  1 
ATOM   2830 C  CE  . MET A 1 395 ? -6.133  -31.288 -34.538 1.00 28.49  ? 658  MET A CE  1 
ATOM   2831 N  N   . ALA A 1 396 ? -7.835  -37.341 -33.064 1.00 25.14  ? 659  ALA A N   1 
ATOM   2832 C  CA  . ALA A 1 396 ? -9.006  -37.737 -32.278 1.00 24.99  ? 659  ALA A CA  1 
ATOM   2833 C  C   . ALA A 1 396 ? -8.941  -36.972 -30.949 1.00 25.00  ? 659  ALA A C   1 
ATOM   2834 O  O   . ALA A 1 396 ? -7.990  -37.174 -30.242 1.00 24.69  ? 659  ALA A O   1 
ATOM   2835 C  CB  . ALA A 1 396 ? -9.032  -39.234 -32.105 1.00 25.48  ? 659  ALA A CB  1 
ATOM   2836 N  N   . ILE A 1 397 ? -9.919  -36.111 -30.664 1.00 24.00  ? 660  ILE A N   1 
ATOM   2837 C  CA  . ILE A 1 397 ? -9.896  -35.214 -29.485 1.00 26.27  ? 660  ILE A CA  1 
ATOM   2838 C  C   . ILE A 1 397 ? -11.211 -35.346 -28.696 1.00 27.28  ? 660  ILE A C   1 
ATOM   2839 O  O   . ILE A 1 397 ? -12.293 -35.097 -29.231 1.00 26.75  ? 660  ILE A O   1 
ATOM   2840 C  CB  . ILE A 1 397 ? -9.556  -33.774 -29.918 1.00 25.57  ? 660  ILE A CB  1 
ATOM   2841 C  CG1 . ILE A 1 397 ? -8.187  -33.772 -30.605 1.00 30.30  ? 660  ILE A CG1 1 
ATOM   2842 C  CG2 . ILE A 1 397 ? -9.592  -32.846 -28.710 1.00 26.94  ? 660  ILE A CG2 1 
ATOM   2843 C  CD1 . ILE A 1 397 ? -7.621  -32.441 -31.087 1.00 31.40  ? 660  ILE A CD1 1 
ATOM   2844 N  N   . SER A 1 398 ? -11.082 -35.646 -27.414 1.00 28.43  ? 661  SER A N   1 
ATOM   2845 C  CA  . SER A 1 398 ? -12.195 -35.752 -26.465 1.00 29.09  ? 661  SER A CA  1 
ATOM   2846 C  C   . SER A 1 398 ? -11.891 -34.901 -25.248 1.00 31.35  ? 661  SER A C   1 
ATOM   2847 O  O   . SER A 1 398 ? -11.185 -35.404 -24.342 1.00 30.38  ? 661  SER A O   1 
ATOM   2848 C  CB  . SER A 1 398 ? -12.426 -37.184 -26.091 1.00 29.23  ? 661  SER A CB  1 
ATOM   2849 O  OG  . SER A 1 398 ? -13.605 -37.300 -25.335 1.00 27.09  ? 661  SER A OG  1 
ATOM   2850 N  N   . GLY A 1 399 ? -12.407 -33.672 -25.226 1.00 27.45  ? 662  GLY A N   1 
ATOM   2851 C  CA  . GLY A 1 399 ? -12.007 -32.694 -24.200 1.00 28.90  ? 662  GLY A CA  1 
ATOM   2852 C  C   . GLY A 1 399 ? -10.495 -32.526 -24.100 1.00 28.61  ? 662  GLY A C   1 
ATOM   2853 O  O   . GLY A 1 399 ? -9.838  -32.221 -25.166 1.00 27.99  ? 662  GLY A O   1 
ATOM   2854 N  N   . ASP A 1 400 ? -9.925  -32.744 -22.903 1.00 26.06  ? 663  ASP A N   1 
ATOM   2855 C  CA  . ASP A 1 400 ? -8.471  -32.542 -22.677 1.00 28.68  ? 663  ASP A CA  1 
ATOM   2856 C  C   . ASP A 1 400 ? -7.679  -33.719 -23.232 1.00 27.82  ? 663  ASP A C   1 
ATOM   2857 O  O   . ASP A 1 400 ? -6.427  -33.671 -23.216 1.00 26.21  ? 663  ASP A O   1 
ATOM   2858 C  CB  . ASP A 1 400 ? -8.132  -32.285 -21.209 1.00 34.05  ? 663  ASP A CB  1 
ATOM   2859 C  CG  . ASP A 1 400 ? -8.422  -33.466 -20.305 1.00 37.60  ? 663  ASP A CG  1 
ATOM   2860 O  OD1 . ASP A 1 400 ? -9.133  -34.344 -20.733 1.00 38.81  ? 663  ASP A OD1 1 
ATOM   2861 O  OD2 . ASP A 1 400 ? -7.882  -33.500 -19.198 1.00 45.70  ? 663  ASP A OD2 1 
ATOM   2862 N  N   . ASP A 1 401 ? -8.347  -34.733 -23.758 1.00 28.60  ? 664  ASP A N   1 
ATOM   2863 C  CA  . ASP A 1 401 ? -7.654  -35.976 -24.154 1.00 26.16  ? 664  ASP A CA  1 
ATOM   2864 C  C   . ASP A 1 401 ? -7.474  -35.945 -25.658 1.00 25.23  ? 664  ASP A C   1 
ATOM   2865 O  O   . ASP A 1 401 ? -8.450  -35.627 -26.312 1.00 28.49  ? 664  ASP A O   1 
ATOM   2866 C  CB  . ASP A 1 401 ? -8.436  -37.213 -23.731 1.00 31.40  ? 664  ASP A CB  1 
ATOM   2867 C  CG  . ASP A 1 401 ? -7.528  -38.421 -23.670 1.00 33.76  ? 664  ASP A CG  1 
ATOM   2868 O  OD1 . ASP A 1 401 ? -6.361  -38.201 -23.658 1.00 39.17  ? 664  ASP A OD1 1 
ATOM   2869 O  OD2 . ASP A 1 401 ? -7.997  -39.517 -23.665 1.00 39.69  ? 664  ASP A OD2 1 
ATOM   2870 N  N   . CYS A 1 402 ? -6.275  -36.215 -26.171 1.00 27.82  ? 665  CYS A N   1 
ATOM   2871 C  CA  . CYS A 1 402 ? -5.984  -36.201 -27.628 1.00 25.35  ? 665  CYS A CA  1 
ATOM   2872 C  C   . CYS A 1 402 ? -5.062  -37.333 -28.085 1.00 28.09  ? 665  CYS A C   1 
ATOM   2873 O  O   . CYS A 1 402 ? -4.129  -37.727 -27.339 1.00 28.52  ? 665  CYS A O   1 
ATOM   2874 C  CB  . CYS A 1 402 ? -5.378  -34.874 -28.053 1.00 30.08  ? 665  CYS A CB  1 
ATOM   2875 S  SG  . CYS A 1 402 ? -3.717  -34.554 -27.401 1.00 31.41  ? 665  CYS A SG  1 
ATOM   2876 N  N   . VAL A 1 403 ? -5.250  -37.715 -29.355 1.00 27.37  ? 666  VAL A N   1 
ATOM   2877 C  CA  . VAL A 1 403 ? -4.329  -38.535 -30.183 1.00 27.18  ? 666  VAL A CA  1 
ATOM   2878 C  C   . VAL A 1 403 ? -4.062  -37.722 -31.461 1.00 27.78  ? 666  VAL A C   1 
ATOM   2879 O  O   . VAL A 1 403 ? -5.026  -37.271 -32.072 1.00 29.02  ? 666  VAL A O   1 
ATOM   2880 C  CB  . VAL A 1 403 ? -4.931  -39.924 -30.449 1.00 26.85  ? 666  VAL A CB  1 
ATOM   2881 C  CG1 . VAL A 1 403 ? -4.085  -40.771 -31.398 1.00 26.41  ? 666  VAL A CG1 1 
ATOM   2882 C  CG2 . VAL A 1 403 ? -5.179  -40.668 -29.118 1.00 24.23  ? 666  VAL A CG2 1 
ATOM   2883 N  N   . VAL A 1 404 ? -2.800  -37.481 -31.804 1.00 26.08  ? 667  VAL A N   1 
ATOM   2884 C  CA  . VAL A 1 404 ? -2.397  -36.760 -33.064 1.00 28.79  ? 667  VAL A CA  1 
ATOM   2885 C  C   . VAL A 1 404 ? -1.467  -37.637 -33.891 1.00 24.70  ? 667  VAL A C   1 
ATOM   2886 O  O   . VAL A 1 404 ? -0.445  -38.109 -33.349 1.00 28.66  ? 667  VAL A O   1 
ATOM   2887 C  CB  . VAL A 1 404 ? -1.708  -35.419 -32.748 1.00 28.44  ? 667  VAL A CB  1 
ATOM   2888 C  CG1 . VAL A 1 404 ? -1.397  -34.631 -34.013 1.00 27.02  ? 667  VAL A CG1 1 
ATOM   2889 C  CG2 . VAL A 1 404 ? -2.525  -34.577 -31.758 1.00 29.20  ? 667  VAL A CG2 1 
ATOM   2890 N  N   . LYS A 1 405 ? -1.783  -37.844 -35.154 1.00 27.15  ? 668  LYS A N   1 
ATOM   2891 C  CA  . LYS A 1 405 ? -0.806  -38.410 -36.117 1.00 28.30  ? 668  LYS A CA  1 
ATOM   2892 C  C   . LYS A 1 405 ? -0.330  -37.293 -37.046 1.00 33.75  ? 668  LYS A C   1 
ATOM   2893 O  O   . LYS A 1 405 ? -0.924  -37.044 -38.104 1.00 27.97  ? 668  LYS A O   1 
ATOM   2894 C  CB  . LYS A 1 405 ? -1.359  -39.545 -36.967 1.00 30.37  ? 668  LYS A CB  1 
ATOM   2895 C  CG  . LYS A 1 405 ? -0.234  -40.261 -37.704 1.00 32.46  ? 668  LYS A CG  1 
ATOM   2896 C  CD  . LYS A 1 405 ? -0.606  -41.444 -38.543 1.00 34.49  ? 668  LYS A CD  1 
ATOM   2897 C  CE  . LYS A 1 405 ? 0.653   -41.982 -39.208 1.00 38.40  ? 668  LYS A CE  1 
ATOM   2898 N  NZ  . LYS A 1 405 ? 0.450   -43.320 -39.794 1.00 41.22  ? 668  LYS A NZ  1 
ATOM   2899 N  N   . PRO A 1 406 ? 0.764   -36.599 -36.687 1.00 31.32  ? 669  PRO A N   1 
ATOM   2900 C  CA  . PRO A 1 406 ? 1.268   -35.507 -37.522 1.00 30.58  ? 669  PRO A CA  1 
ATOM   2901 C  C   . PRO A 1 406 ? 1.926   -35.996 -38.816 1.00 30.08  ? 669  PRO A C   1 
ATOM   2902 O  O   . PRO A 1 406 ? 2.144   -37.193 -39.038 1.00 32.07  ? 669  PRO A O   1 
ATOM   2903 C  CB  . PRO A 1 406 ? 2.246   -34.817 -36.578 1.00 30.31  ? 669  PRO A CB  1 
ATOM   2904 C  CG  . PRO A 1 406 ? 2.783   -35.998 -35.785 1.00 33.04  ? 669  PRO A CG  1 
ATOM   2905 C  CD  . PRO A 1 406 ? 1.555   -36.810 -35.471 1.00 31.61  ? 669  PRO A CD  1 
ATOM   2906 N  N   . LEU A 1 407 ? 2.200   -35.031 -39.689 1.00 36.33  ? 670  LEU A N   1 
ATOM   2907 C  CA  . LEU A 1 407 ? 2.888   -35.227 -40.991 1.00 37.35  ? 670  LEU A CA  1 
ATOM   2908 C  C   . LEU A 1 407 ? 4.193   -36.028 -40.780 1.00 33.15  ? 670  LEU A C   1 
ATOM   2909 O  O   . LEU A 1 407 ? 4.456   -36.928 -41.555 1.00 34.04  ? 670  LEU A O   1 
ATOM   2910 C  CB  . LEU A 1 407 ? 3.115   -33.831 -41.592 1.00 37.92  ? 670  LEU A CB  1 
ATOM   2911 C  CG  . LEU A 1 407 ? 3.086   -33.764 -43.113 1.00 43.30  ? 670  LEU A CG  1 
ATOM   2912 C  CD1 . LEU A 1 407 ? 1.705   -34.086 -43.641 1.00 44.00  ? 670  LEU A CD1 1 
ATOM   2913 C  CD2 . LEU A 1 407 ? 3.551   -32.402 -43.614 1.00 48.04  ? 670  LEU A CD2 1 
ATOM   2914 N  N   . ASP A 1 408 ? 4.948   -35.777 -39.711 1.00 31.95  ? 671  ASP A N   1 
ATOM   2915 C  CA  . ASP A 1 408 ? 6.246   -36.468 -39.458 1.00 34.66  ? 671  ASP A CA  1 
ATOM   2916 C  C   . ASP A 1 408 ? 6.613   -36.295 -37.990 1.00 31.73  ? 671  ASP A C   1 
ATOM   2917 O  O   . ASP A 1 408 ? 5.815   -35.697 -37.308 1.00 34.01  ? 671  ASP A O   1 
ATOM   2918 C  CB  . ASP A 1 408 ? 7.329   -35.941 -40.420 1.00 35.44  ? 671  ASP A CB  1 
ATOM   2919 C  CG  . ASP A 1 408 ? 7.299   -34.451 -40.531 1.00 31.85  ? 671  ASP A CG  1 
ATOM   2920 O  OD1 . ASP A 1 408 ? 7.541   -33.788 -39.483 1.00 35.53  ? 671  ASP A OD1 1 
ATOM   2921 O  OD2 . ASP A 1 408 ? 6.955   -33.961 -41.637 1.00 38.03  ? 671  ASP A OD2 1 
ATOM   2922 N  N   . ASP A 1 409 ? 7.805   -36.720 -37.555 1.00 32.07  ? 672  ASP A N   1 
ATOM   2923 C  CA  . ASP A 1 409 ? 8.157   -36.746 -36.108 1.00 32.98  ? 672  ASP A CA  1 
ATOM   2924 C  C   . ASP A 1 409 ? 8.794   -35.432 -35.638 1.00 29.95  ? 672  ASP A C   1 
ATOM   2925 O  O   . ASP A 1 409 ? 9.094   -35.332 -34.445 1.00 33.51  ? 672  ASP A O   1 
ATOM   2926 C  CB  . ASP A 1 409 ? 8.896   -38.039 -35.775 1.00 32.05  ? 672  ASP A CB  1 
ATOM   2927 C  CG  . ASP A 1 409 ? 7.977   -39.239 -35.906 1.00 34.06  ? 672  ASP A CG  1 
ATOM   2928 O  OD1 . ASP A 1 409 ? 6.851   -39.187 -35.328 1.00 32.80  ? 672  ASP A OD1 1 
ATOM   2929 O  OD2 . ASP A 1 409 ? 8.364   -40.197 -36.635 1.00 37.73  ? 672  ASP A OD2 1 
ATOM   2930 N  N   . ARG A 1 410 ? 8.823   -34.378 -36.461 1.00 37.21  ? 673  ARG A N   1 
ATOM   2931 C  CA  . ARG A 1 410 ? 9.321   -33.053 -35.994 1.00 33.81  ? 673  ARG A CA  1 
ATOM   2932 C  C   . ARG A 1 410 ? 8.399   -32.560 -34.878 1.00 32.18  ? 673  ARG A C   1 
ATOM   2933 O  O   . ARG A 1 410 ? 8.863   -31.798 -34.003 1.00 35.51  ? 673  ARG A O   1 
ATOM   2934 C  CB  . ARG A 1 410 ? 9.326   -32.026 -37.127 1.00 37.60  ? 673  ARG A CB  1 
ATOM   2935 C  CG  . ARG A 1 410 ? 10.395  -32.216 -38.194 1.00 39.84  ? 673  ARG A CG  1 
ATOM   2936 C  CD  . ARG A 1 410 ? 10.226  -31.179 -39.299 1.00 36.61  ? 673  ARG A CD  1 
ATOM   2937 N  NE  . ARG A 1 410 ? 9.088   -31.493 -40.135 1.00 37.58  ? 673  ARG A NE  1 
ATOM   2938 C  CZ  . ARG A 1 410 ? 8.558   -30.685 -41.060 1.00 43.48  ? 673  ARG A CZ  1 
ATOM   2939 N  NH1 . ARG A 1 410 ? 9.083   -29.489 -41.297 1.00 35.12  ? 673  ARG A NH1 1 
ATOM   2940 N  NH2 . ARG A 1 410 ? 7.508   -31.096 -41.766 1.00 42.62  ? 673  ARG A NH2 1 
ATOM   2941 N  N   . PHE A 1 411 ? 7.106   -32.926 -34.957 1.00 33.56  ? 674  PHE A N   1 
ATOM   2942 C  CA  . PHE A 1 411 ? 6.030   -32.683 -33.953 1.00 27.99  ? 674  PHE A CA  1 
ATOM   2943 C  C   . PHE A 1 411 ? 6.546   -32.983 -32.552 1.00 27.22  ? 674  PHE A C   1 
ATOM   2944 O  O   . PHE A 1 411 ? 6.197   -32.179 -31.619 1.00 30.66  ? 674  PHE A O   1 
ATOM   2945 C  CB  . PHE A 1 411 ? 4.804   -33.572 -34.256 1.00 31.37  ? 674  PHE A CB  1 
ATOM   2946 C  CG  . PHE A 1 411 ? 3.577   -33.376 -33.404 1.00 29.25  ? 674  PHE A CG  1 
ATOM   2947 C  CD1 . PHE A 1 411 ? 3.369   -34.136 -32.256 1.00 32.37  ? 674  PHE A CD1 1 
ATOM   2948 C  CD2 . PHE A 1 411 ? 2.607   -32.452 -33.762 1.00 31.23  ? 674  PHE A CD2 1 
ATOM   2949 C  CE1 . PHE A 1 411 ? 2.218   -33.960 -31.482 1.00 30.21  ? 674  PHE A CE1 1 
ATOM   2950 C  CE2 . PHE A 1 411 ? 1.463   -32.273 -32.995 1.00 30.28  ? 674  PHE A CE2 1 
ATOM   2951 C  CZ  . PHE A 1 411 ? 1.272   -33.022 -31.842 1.00 29.63  ? 674  PHE A CZ  1 
ATOM   2952 N  N   . ALA A 1 412 ? 7.303   -34.083 -32.382 1.00 29.60  ? 675  ALA A N   1 
ATOM   2953 C  CA  . ALA A 1 412 ? 7.747   -34.592 -31.053 1.00 30.14  ? 675  ALA A CA  1 
ATOM   2954 C  C   . ALA A 1 412 ? 8.548   -33.547 -30.272 1.00 32.50  ? 675  ALA A C   1 
ATOM   2955 O  O   . ALA A 1 412 ? 8.399   -33.509 -29.044 1.00 29.42  ? 675  ALA A O   1 
ATOM   2956 C  CB  . ALA A 1 412 ? 8.564   -35.861 -31.191 1.00 31.29  ? 675  ALA A CB  1 
ATOM   2957 N  N   . SER A 1 413 ? 9.383   -32.754 -30.956 1.00 33.73  ? 676  SER A N   1 
ATOM   2958 C  CA  . SER A 1 413 ? 10.228  -31.700 -30.328 1.00 37.78  ? 676  SER A CA  1 
ATOM   2959 C  C   . SER A 1 413 ? 9.654   -30.293 -30.540 1.00 38.35  ? 676  SER A C   1 
ATOM   2960 O  O   . SER A 1 413 ? 10.301  -29.361 -30.092 1.00 38.79  ? 676  SER A O   1 
ATOM   2961 C  CB  . SER A 1 413 ? 11.684  -31.797 -30.809 1.00 35.81  ? 676  SER A CB  1 
ATOM   2962 O  OG  . SER A 1 413 ? 11.711  -32.058 -32.201 1.00 42.11  ? 676  SER A OG  1 
ATOM   2963 N  N   . ALA A 1 414 ? 8.464   -30.123 -31.132 1.00 37.87  ? 677  ALA A N   1 
ATOM   2964 C  CA  . ALA A 1 414 ? 7.825   -28.793 -31.320 1.00 34.22  ? 677  ALA A CA  1 
ATOM   2965 C  C   . ALA A 1 414 ? 7.066   -28.416 -30.044 1.00 36.10  ? 677  ALA A C   1 
ATOM   2966 O  O   . ALA A 1 414 ? 5.855   -28.770 -29.971 1.00 37.31  ? 677  ALA A O   1 
ATOM   2967 C  CB  . ALA A 1 414 ? 6.917   -28.844 -32.516 1.00 33.79  ? 677  ALA A CB  1 
ATOM   2968 N  N   . LEU A 1 415 ? 7.706   -27.756 -29.072 1.00 33.75  ? 678  LEU A N   1 
ATOM   2969 C  CA  . LEU A 1 415 ? 7.184   -27.635 -27.674 1.00 35.47  ? 678  LEU A CA  1 
ATOM   2970 C  C   . LEU A 1 415 ? 6.983   -26.182 -27.234 1.00 36.41  ? 678  LEU A C   1 
ATOM   2971 O  O   . LEU A 1 415 ? 6.402   -25.980 -26.131 1.00 41.38  ? 678  LEU A O   1 
ATOM   2972 C  CB  . LEU A 1 415 ? 8.104   -28.377 -26.691 1.00 36.48  ? 678  LEU A CB  1 
ATOM   2973 C  CG  . LEU A 1 415 ? 8.272   -29.888 -26.955 1.00 38.34  ? 678  LEU A CG  1 
ATOM   2974 C  CD1 . LEU A 1 415 ? 9.381   -30.531 -26.101 1.00 37.27  ? 678  LEU A CD1 1 
ATOM   2975 C  CD2 . LEU A 1 415 ? 6.965   -30.640 -26.750 1.00 37.92  ? 678  LEU A CD2 1 
ATOM   2976 N  N   . THR A 1 416 ? 7.381   -25.189 -28.028 1.00 35.33  ? 679  THR A N   1 
ATOM   2977 C  CA  . THR A 1 416 ? 7.484   -23.798 -27.513 1.00 36.93  ? 679  THR A CA  1 
ATOM   2978 C  C   . THR A 1 416 ? 6.079   -23.212 -27.414 1.00 34.95  ? 679  THR A C   1 
ATOM   2979 O  O   . THR A 1 416 ? 5.749   -22.640 -26.343 1.00 35.75  ? 679  THR A O   1 
ATOM   2980 C  CB  . THR A 1 416 ? 8.412   -22.913 -28.360 1.00 41.93  ? 679  THR A CB  1 
ATOM   2981 O  OG1 . THR A 1 416 ? 7.859   -22.624 -29.645 1.00 41.77  ? 679  THR A OG1 1 
ATOM   2982 C  CG2 . THR A 1 416 ? 9.768   -23.545 -28.588 1.00 46.83  ? 679  THR A CG2 1 
ATOM   2983 N  N   . ALA A 1 417 ? 5.274   -23.317 -28.481 1.00 35.18  ? 680  ALA A N   1 
ATOM   2984 C  CA  . ALA A 1 417 ? 3.874   -22.818 -28.453 1.00 34.96  ? 680  ALA A CA  1 
ATOM   2985 C  C   . ALA A 1 417 ? 3.097   -23.570 -27.352 1.00 37.51  ? 680  ALA A C   1 
ATOM   2986 O  O   . ALA A 1 417 ? 2.405   -22.883 -26.519 1.00 38.47  ? 680  ALA A O   1 
ATOM   2987 C  CB  . ALA A 1 417 ? 3.239   -22.934 -29.821 1.00 35.02  ? 680  ALA A CB  1 
ATOM   2988 N  N   . LEU A 1 418 ? 3.206   -24.917 -27.322 1.00 38.24  ? 681  LEU A N   1 
ATOM   2989 C  CA  . LEU A 1 418 ? 2.437   -25.782 -26.387 1.00 35.86  ? 681  LEU A CA  1 
ATOM   2990 C  C   . LEU A 1 418 ? 2.766   -25.391 -24.948 1.00 35.91  ? 681  LEU A C   1 
ATOM   2991 O  O   . LEU A 1 418 ? 1.822   -25.165 -24.166 1.00 36.01  ? 681  LEU A O   1 
ATOM   2992 C  CB  . LEU A 1 418 ? 2.755   -27.251 -26.663 1.00 38.54  ? 681  LEU A CB  1 
ATOM   2993 C  CG  . LEU A 1 418 ? 1.913   -28.265 -25.882 1.00 40.65  ? 681  LEU A CG  1 
ATOM   2994 C  CD1 . LEU A 1 418 ? 0.531   -28.390 -26.506 1.00 38.08  ? 681  LEU A CD1 1 
ATOM   2995 C  CD2 . LEU A 1 418 ? 2.609   -29.616 -25.831 1.00 37.54  ? 681  LEU A CD2 1 
ATOM   2996 N  N   . ASN A 1 419 ? 4.055   -25.232 -24.624 1.00 39.55  ? 682  ASN A N   1 
ATOM   2997 C  CA  . ASN A 1 419 ? 4.459   -24.830 -23.251 1.00 38.79  ? 682  ASN A CA  1 
ATOM   2998 C  C   . ASN A 1 419 ? 3.938   -23.415 -22.960 1.00 37.70  ? 682  ASN A C   1 
ATOM   2999 O  O   . ASN A 1 419 ? 3.298   -23.224 -21.901 1.00 37.57  ? 682  ASN A O   1 
ATOM   3000 C  CB  . ASN A 1 419 ? 5.966   -24.975 -23.063 1.00 40.37  ? 682  ASN A CB  1 
ATOM   3001 C  CG  . ASN A 1 419 ? 6.364   -26.414 -22.793 1.00 40.74  ? 682  ASN A CG  1 
ATOM   3002 O  OD1 . ASN A 1 419 ? 5.618   -27.164 -22.169 1.00 43.51  ? 682  ASN A OD1 1 
ATOM   3003 N  ND2 . ASN A 1 419 ? 7.543   -26.799 -23.225 1.00 37.35  ? 682  ASN A ND2 1 
ATOM   3004 N  N   . ASP A 1 420 ? 4.154   -22.465 -23.878 1.00 35.31  ? 683  ASP A N   1 
ATOM   3005 C  CA  . ASP A 1 420 ? 3.797   -21.035 -23.685 1.00 36.75  ? 683  ASP A CA  1 
ATOM   3006 C  C   . ASP A 1 420 ? 2.276   -20.837 -23.601 1.00 36.59  ? 683  ASP A C   1 
ATOM   3007 O  O   . ASP A 1 420 ? 1.864   -19.907 -22.894 1.00 35.75  ? 683  ASP A O   1 
ATOM   3008 C  CB  . ASP A 1 420 ? 4.367   -20.130 -24.792 1.00 40.93  ? 683  ASP A CB  1 
ATOM   3009 C  CG  . ASP A 1 420 ? 4.284   -18.646 -24.448 1.00 40.85  ? 683  ASP A CG  1 
ATOM   3010 O  OD1 . ASP A 1 420 ? 4.678   -18.293 -23.316 1.00 37.63  ? 683  ASP A OD1 1 
ATOM   3011 O  OD2 . ASP A 1 420 ? 3.795   -17.861 -25.300 1.00 38.29  ? 683  ASP A OD2 1 
ATOM   3012 N  N   . MET A 1 421 ? 1.459   -21.635 -24.301 1.00 36.52  ? 684  MET A N   1 
ATOM   3013 C  CA  . MET A 1 421 ? -0.029  -21.608 -24.114 1.00 33.56  ? 684  MET A CA  1 
ATOM   3014 C  C   . MET A 1 421 ? -0.394  -22.102 -22.710 1.00 33.58  ? 684  MET A C   1 
ATOM   3015 O  O   . MET A 1 421 ? -1.562  -22.010 -22.373 1.00 38.13  ? 684  MET A O   1 
ATOM   3016 C  CB  . MET A 1 421 ? -0.751  -22.474 -25.152 1.00 34.89  ? 684  MET A CB  1 
ATOM   3017 C  CG  . MET A 1 421 ? -0.560  -21.963 -26.565 1.00 34.32  ? 684  MET A CG  1 
ATOM   3018 S  SD  . MET A 1 421 ? -1.549  -22.852 -27.786 1.00 42.81  ? 684  MET A SD  1 
ATOM   3019 C  CE  . MET A 1 421 ? -0.463  -24.155 -28.360 1.00 46.05  ? 684  MET A CE  1 
ATOM   3020 N  N   . GLY A 1 422 ? 0.552   -22.683 -21.964 1.00 35.88  ? 685  GLY A N   1 
ATOM   3021 C  CA  . GLY A 1 422 ? 0.346   -23.245 -20.602 1.00 34.31  ? 685  GLY A CA  1 
ATOM   3022 C  C   . GLY A 1 422 ? -0.110  -24.694 -20.589 1.00 33.02  ? 685  GLY A C   1 
ATOM   3023 O  O   . GLY A 1 422 ? -0.366  -25.196 -19.473 1.00 32.28  ? 685  GLY A O   1 
ATOM   3024 N  N   . LYS A 1 423 ? -0.181  -25.370 -21.753 1.00 32.77  ? 686  LYS A N   1 
ATOM   3025 C  CA  . LYS A 1 423 ? -0.626  -26.797 -21.871 1.00 35.75  ? 686  LYS A CA  1 
ATOM   3026 C  C   . LYS A 1 423 ? 0.579   -27.735 -21.668 1.00 38.63  ? 686  LYS A C   1 
ATOM   3027 O  O   . LYS A 1 423 ? 0.892   -28.588 -22.535 1.00 35.81  ? 686  LYS A O   1 
ATOM   3028 C  CB  . LYS A 1 423 ? -1.428  -26.988 -23.162 1.00 32.41  ? 686  LYS A CB  1 
ATOM   3029 C  CG  . LYS A 1 423 ? -2.577  -25.987 -23.312 1.00 33.20  ? 686  LYS A CG  1 
ATOM   3030 C  CD  . LYS A 1 423 ? -3.476  -25.921 -22.059 1.00 33.60  ? 686  LYS A CD  1 
ATOM   3031 C  CE  . LYS A 1 423 ? -4.638  -24.950 -22.115 1.00 34.72  ? 686  LYS A CE  1 
ATOM   3032 N  NZ  . LYS A 1 423 ? -4.210  -23.567 -22.461 1.00 38.26  ? 686  LYS A NZ  1 
ATOM   3033 N  N   . VAL A 1 424 ? 1.165   -27.628 -20.477 1.00 41.39  ? 687  VAL A N   1 
ATOM   3034 C  CA  . VAL A 1 424 ? 2.369   -28.383 -20.018 1.00 41.24  ? 687  VAL A CA  1 
ATOM   3035 C  C   . VAL A 1 424 ? 2.016   -29.868 -19.912 1.00 33.08  ? 687  VAL A C   1 
ATOM   3036 O  O   . VAL A 1 424 ? 1.020   -30.210 -19.185 1.00 41.00  ? 687  VAL A O   1 
ATOM   3037 C  CB  . VAL A 1 424 ? 2.860   -27.781 -18.681 1.00 44.03  ? 687  VAL A CB  1 
ATOM   3038 C  CG1 . VAL A 1 424 ? 3.796   -28.690 -17.907 1.00 48.37  ? 687  VAL A CG1 1 
ATOM   3039 C  CG2 . VAL A 1 424 ? 3.500   -26.420 -18.918 1.00 43.20  ? 687  VAL A CG2 1 
ATOM   3040 N  N   . ARG A 1 425 ? 2.838   -30.706 -20.551 1.00 32.60  ? 688  ARG A N   1 
ATOM   3041 C  CA  . ARG A 1 425 ? 2.645   -32.171 -20.639 1.00 35.74  ? 688  ARG A CA  1 
ATOM   3042 C  C   . ARG A 1 425 ? 2.911   -32.770 -19.260 1.00 36.93  ? 688  ARG A C   1 
ATOM   3043 O  O   . ARG A 1 425 ? 3.811   -32.252 -18.528 1.00 41.01  ? 688  ARG A O   1 
ATOM   3044 C  CB  . ARG A 1 425 ? 3.539   -32.823 -21.690 1.00 32.22  ? 688  ARG A CB  1 
ATOM   3045 C  CG  . ARG A 1 425 ? 3.271   -32.334 -23.099 1.00 39.05  ? 688  ARG A CG  1 
ATOM   3046 C  CD  . ARG A 1 425 ? 4.393   -32.685 -24.045 1.00 37.02  ? 688  ARG A CD  1 
ATOM   3047 N  NE  . ARG A 1 425 ? 5.643   -32.097 -23.591 1.00 39.11  ? 688  ARG A NE  1 
ATOM   3048 C  CZ  . ARG A 1 425 ? 6.873   -32.548 -23.883 1.00 39.99  ? 688  ARG A CZ  1 
ATOM   3049 N  NH1 . ARG A 1 425 ? 7.062   -33.581 -24.689 1.00 36.21  ? 688  ARG A NH1 1 
ATOM   3050 N  NH2 . ARG A 1 425 ? 7.923   -31.932 -23.370 1.00 42.42  ? 688  ARG A NH2 1 
ATOM   3051 N  N   . LYS A 1 426 ? 2.155   -33.817 -18.911 0.35 37.89  ? 689  LYS A N   1 
ATOM   3052 C  CA  . LYS A 1 426 ? 2.200   -34.518 -17.597 0.35 40.00  ? 689  LYS A CA  1 
ATOM   3053 C  C   . LYS A 1 426 ? 3.247   -35.644 -17.634 0.35 40.27  ? 689  LYS A C   1 
ATOM   3054 O  O   . LYS A 1 426 ? 3.144   -36.511 -18.520 0.35 39.55  ? 689  LYS A O   1 
ATOM   3055 C  CB  . LYS A 1 426 ? 0.822   -35.097 -17.268 0.35 42.18  ? 689  LYS A CB  1 
ATOM   3056 C  CG  . LYS A 1 426 ? 0.710   -35.798 -15.920 0.35 44.63  ? 689  LYS A CG  1 
ATOM   3057 C  CD  . LYS A 1 426 ? -0.556  -36.608 -15.748 0.35 46.66  ? 689  LYS A CD  1 
ATOM   3058 C  CE  . LYS A 1 426 ? -0.828  -37.539 -16.911 0.35 50.20  ? 689  LYS A CE  1 
ATOM   3059 N  NZ  . LYS A 1 426 ? -1.788  -38.609 -16.553 0.35 51.43  ? 689  LYS A NZ  1 
ATOM   3060 N  N   . ASP A 1 427 ? 4.201   -35.627 -16.695 0.35 40.81  ? 690  ASP A N   1 
ATOM   3061 C  CA  . ASP A 1 427 ? 5.181   -36.722 -16.437 0.35 41.09  ? 690  ASP A CA  1 
ATOM   3062 C  C   . ASP A 1 427 ? 6.144   -36.860 -17.624 0.35 43.55  ? 690  ASP A C   1 
ATOM   3063 O  O   . ASP A 1 427 ? 6.285   -37.981 -18.171 0.35 46.14  ? 690  ASP A O   1 
ATOM   3064 C  CB  . ASP A 1 427 ? 4.461   -38.028 -16.099 0.35 39.55  ? 690  ASP A CB  1 
ATOM   3065 C  CG  . ASP A 1 427 ? 3.932   -38.053 -14.680 0.35 38.93  ? 690  ASP A CG  1 
ATOM   3066 O  OD1 . ASP A 1 427 ? 4.299   -37.146 -13.903 0.35 35.89  ? 690  ASP A OD1 1 
ATOM   3067 O  OD2 . ASP A 1 427 ? 3.167   -38.984 -14.364 0.35 40.97  ? 690  ASP A OD2 1 
ATOM   3068 N  N   . ILE A 1 428 ? 6.761   -35.739 -18.000 0.35 42.75  ? 691  ILE A N   1 
ATOM   3069 C  CA  . ILE A 1 428 ? 7.903   -35.637 -18.955 0.35 43.13  ? 691  ILE A CA  1 
ATOM   3070 C  C   . ILE A 1 428 ? 8.487   -34.232 -18.795 0.35 43.13  ? 691  ILE A C   1 
ATOM   3071 O  O   . ILE A 1 428 ? 7.694   -33.276 -18.748 0.35 44.45  ? 691  ILE A O   1 
ATOM   3072 C  CB  . ILE A 1 428 ? 7.467   -35.928 -20.407 0.35 42.89  ? 691  ILE A CB  1 
ATOM   3073 C  CG1 . ILE A 1 428 ? 8.678   -36.028 -21.338 0.35 42.79  ? 691  ILE A CG1 1 
ATOM   3074 C  CG2 . ILE A 1 428 ? 6.462   -34.898 -20.905 0.35 43.32  ? 691  ILE A CG2 1 
ATOM   3075 C  CD1 . ILE A 1 428 ? 8.408   -36.762 -22.627 0.35 41.82  ? 691  ILE A CD1 1 
ATOM   3076 N  N   . GLN A 1 429 ? 9.809   -34.113 -18.665 0.35 43.18  ? 692  GLN A N   1 
ATOM   3077 C  CA  . GLN A 1 429 ? 10.480  -32.805 -18.442 0.35 42.84  ? 692  GLN A CA  1 
ATOM   3078 C  C   . GLN A 1 429 ? 10.081  -31.850 -19.568 0.35 42.04  ? 692  GLN A C   1 
ATOM   3079 O  O   . GLN A 1 429 ? 9.934   -32.300 -20.722 0.35 39.79  ? 692  GLN A O   1 
ATOM   3080 C  CB  . GLN A 1 429 ? 11.998  -32.956 -18.340 0.35 44.67  ? 692  GLN A CB  1 
ATOM   3081 C  CG  . GLN A 1 429 ? 12.464  -33.424 -16.968 0.35 47.10  ? 692  GLN A CG  1 
ATOM   3082 C  CD  . GLN A 1 429 ? 13.806  -32.842 -16.599 0.35 45.95  ? 692  GLN A CD  1 
ATOM   3083 O  OE1 . GLN A 1 429 ? 14.723  -32.787 -17.416 0.35 47.53  ? 692  GLN A OE1 1 
ATOM   3084 N  NE2 . GLN A 1 429 ? 13.930  -32.402 -15.358 0.35 45.02  ? 692  GLN A NE2 1 
ATOM   3085 N  N   . GLN A 1 430 ? 9.938   -30.572 -19.222 0.35 43.09  ? 693  GLN A N   1 
ATOM   3086 C  CA  . GLN A 1 430 ? 9.222   -29.547 -20.023 0.35 44.91  ? 693  GLN A CA  1 
ATOM   3087 C  C   . GLN A 1 430 ? 9.786   -29.484 -21.448 0.35 45.15  ? 693  GLN A C   1 
ATOM   3088 O  O   . GLN A 1 430 ? 8.985   -29.229 -22.372 0.35 45.79  ? 693  GLN A O   1 
ATOM   3089 C  CB  . GLN A 1 430 ? 9.300   -28.187 -19.327 0.35 45.42  ? 693  GLN A CB  1 
ATOM   3090 C  CG  . GLN A 1 430 ? 7.934   -27.561 -19.095 0.35 44.84  ? 693  GLN A CG  1 
ATOM   3091 C  CD  . GLN A 1 430 ? 8.034   -26.158 -18.553 0.35 44.51  ? 693  GLN A CD  1 
ATOM   3092 O  OE1 . GLN A 1 430 ? 9.123   -25.619 -18.378 0.35 42.10  ? 693  GLN A OE1 1 
ATOM   3093 N  NE2 . GLN A 1 430 ? 6.889   -25.556 -18.273 0.35 45.45  ? 693  GLN A NE2 1 
ATOM   3094 N  N   . TRP A 1 431 ? 11.096  -29.697 -21.624 1.00 45.10  ? 694  TRP A N   1 
ATOM   3095 C  CA  . TRP A 1 431 ? 11.751  -29.569 -22.959 1.00 45.68  ? 694  TRP A CA  1 
ATOM   3096 C  C   . TRP A 1 431 ? 12.160  -30.902 -23.604 1.00 44.04  ? 694  TRP A C   1 
ATOM   3097 O  O   . TRP A 1 431 ? 12.734  -30.876 -24.703 1.00 42.05  ? 694  TRP A O   1 
ATOM   3098 C  CB  . TRP A 1 431 ? 12.891  -28.548 -22.857 1.00 53.67  ? 694  TRP A CB  1 
ATOM   3099 C  CG  . TRP A 1 431 ? 12.381  -27.190 -22.455 1.00 59.28  ? 694  TRP A CG  1 
ATOM   3100 C  CD1 . TRP A 1 431 ? 12.566  -26.557 -21.260 1.00 55.36  ? 694  TRP A CD1 1 
ATOM   3101 C  CD2 . TRP A 1 431 ? 11.507  -26.337 -23.226 1.00 54.80  ? 694  TRP A CD2 1 
ATOM   3102 N  NE1 . TRP A 1 431 ? 11.906  -25.356 -21.253 1.00 58.42  ? 694  TRP A NE1 1 
ATOM   3103 C  CE2 . TRP A 1 431 ? 11.254  -25.190 -22.444 1.00 61.12  ? 694  TRP A CE2 1 
ATOM   3104 C  CE3 . TRP A 1 431 ? 10.954  -26.414 -24.508 1.00 53.07  ? 694  TRP A CE3 1 
ATOM   3105 C  CZ2 . TRP A 1 431 ? 10.448  -24.144 -22.895 1.00 61.04  ? 694  TRP A CZ2 1 
ATOM   3106 C  CZ3 . TRP A 1 431 ? 10.179  -25.372 -24.965 1.00 56.26  ? 694  TRP A CZ3 1 
ATOM   3107 C  CH2 . TRP A 1 431 ? 9.917   -24.260 -24.161 1.00 56.74  ? 694  TRP A CH2 1 
ATOM   3108 N  N   . GLU A 1 432 ? 11.822  -32.020 -22.954 0.35 43.49  ? 695  GLU A N   1 
ATOM   3109 C  CA  . GLU A 1 432 ? 12.143  -33.399 -23.407 0.35 45.17  ? 695  GLU A CA  1 
ATOM   3110 C  C   . GLU A 1 432 ? 11.157  -33.780 -24.512 0.35 43.16  ? 695  GLU A C   1 
ATOM   3111 O  O   . GLU A 1 432 ? 9.949   -33.644 -24.330 0.35 41.83  ? 695  GLU A O   1 
ATOM   3112 C  CB  . GLU A 1 432 ? 12.095  -34.348 -22.203 0.35 47.85  ? 695  GLU A CB  1 
ATOM   3113 C  CG  . GLU A 1 432 ? 13.059  -35.517 -22.290 0.35 50.78  ? 695  GLU A CG  1 
ATOM   3114 C  CD  . GLU A 1 432 ? 14.536  -35.148 -22.240 0.35 51.60  ? 695  GLU A CD  1 
ATOM   3115 O  OE1 . GLU A 1 432 ? 15.298  -35.654 -23.091 0.35 52.55  ? 695  GLU A OE1 1 
ATOM   3116 O  OE2 . GLU A 1 432 ? 14.927  -34.357 -21.353 0.35 51.65  ? 695  GLU A OE2 1 
ATOM   3117 N  N   . PRO A 1 433 ? 11.620  -34.244 -25.698 1.00 42.44  ? 696  PRO A N   1 
ATOM   3118 C  CA  . PRO A 1 433 ? 10.703  -34.546 -26.805 1.00 36.61  ? 696  PRO A CA  1 
ATOM   3119 C  C   . PRO A 1 433 ? 9.659   -35.616 -26.465 1.00 39.02  ? 696  PRO A C   1 
ATOM   3120 O  O   . PRO A 1 433 ? 9.950   -36.481 -25.690 1.00 34.26  ? 696  PRO A O   1 
ATOM   3121 C  CB  . PRO A 1 433 ? 11.596  -35.080 -27.932 1.00 42.03  ? 696  PRO A CB  1 
ATOM   3122 C  CG  . PRO A 1 433 ? 13.038  -34.644 -27.527 1.00 44.26  ? 696  PRO A CG  1 
ATOM   3123 C  CD  . PRO A 1 433 ? 13.034  -34.509 -26.021 1.00 41.11  ? 696  PRO A CD  1 
ATOM   3124 N  N   . SER A 1 434 ? 8.452   -35.517 -27.036 1.00 37.53  ? 697  SER A N   1 
ATOM   3125 C  CA  . SER A 1 434 ? 7.366   -36.489 -26.800 1.00 35.02  ? 697  SER A CA  1 
ATOM   3126 C  C   . SER A 1 434 ? 7.822   -37.829 -27.370 1.00 35.46  ? 697  SER A C   1 
ATOM   3127 O  O   . SER A 1 434 ? 8.494   -37.835 -28.380 1.00 39.36  ? 697  SER A O   1 
ATOM   3128 C  CB  . SER A 1 434 ? 6.080   -36.035 -27.484 1.00 31.70  ? 697  SER A CB  1 
ATOM   3129 O  OG  . SER A 1 434 ? 5.548   -34.870 -26.890 1.00 29.69  ? 697  SER A OG  1 
ATOM   3130 N  N   . ARG A 1 435 ? 7.395   -38.927 -26.741 0.35 38.48  ? 698  ARG A N   1 
ATOM   3131 C  CA  . ARG A 1 435 ? 7.604   -40.323 -27.215 0.35 42.45  ? 698  ARG A CA  1 
ATOM   3132 C  C   . ARG A 1 435 ? 6.299   -40.824 -27.853 0.35 42.09  ? 698  ARG A C   1 
ATOM   3133 O  O   . ARG A 1 435 ? 5.283   -40.890 -27.137 0.35 42.86  ? 698  ARG A O   1 
ATOM   3134 C  CB  . ARG A 1 435 ? 8.063   -41.195 -26.039 0.35 46.55  ? 698  ARG A CB  1 
ATOM   3135 C  CG  . ARG A 1 435 ? 9.338   -40.695 -25.372 0.35 50.90  ? 698  ARG A CG  1 
ATOM   3136 C  CD  . ARG A 1 435 ? 9.822   -41.544 -24.207 0.35 56.46  ? 698  ARG A CD  1 
ATOM   3137 N  NE  . ARG A 1 435 ? 9.536   -40.947 -22.904 0.35 61.23  ? 698  ARG A NE  1 
ATOM   3138 C  CZ  . ARG A 1 435 ? 10.200  -39.925 -22.358 0.35 62.96  ? 698  ARG A CZ  1 
ATOM   3139 N  NH1 . ARG A 1 435 ? 11.202  -39.345 -23.001 0.35 62.95  ? 698  ARG A NH1 1 
ATOM   3140 N  NH2 . ARG A 1 435 ? 9.845   -39.475 -21.165 0.35 63.48  ? 698  ARG A NH2 1 
ATOM   3141 N  N   . GLY A 1 436 ? 6.326   -41.159 -29.148 1.00 41.06  ? 699  GLY A N   1 
ATOM   3142 C  CA  . GLY A 1 436 ? 5.122   -41.551 -29.901 1.00 41.70  ? 699  GLY A CA  1 
ATOM   3143 C  C   . GLY A 1 436 ? 4.877   -43.046 -29.855 1.00 40.27  ? 699  GLY A C   1 
ATOM   3144 O  O   . GLY A 1 436 ? 5.769   -43.779 -29.456 1.00 41.48  ? 699  GLY A O   1 
ATOM   3145 N  N   . TRP A 1 437 ? 3.716   -43.487 -30.323 1.00 34.92  ? 700  TRP A N   1 
ATOM   3146 C  CA  . TRP A 1 437 ? 3.388   -44.919 -30.443 1.00 28.67  ? 700  TRP A CA  1 
ATOM   3147 C  C   . TRP A 1 437 ? 3.497   -45.317 -31.907 1.00 30.88  ? 700  TRP A C   1 
ATOM   3148 O  O   . TRP A 1 437 ? 3.003   -44.573 -32.749 1.00 33.20  ? 700  TRP A O   1 
ATOM   3149 C  CB  . TRP A 1 437 ? 1.990   -45.154 -29.908 1.00 28.81  ? 700  TRP A CB  1 
ATOM   3150 C  CG  . TRP A 1 437 ? 1.825   -44.660 -28.509 1.00 28.42  ? 700  TRP A CG  1 
ATOM   3151 C  CD1 . TRP A 1 437 ? 1.471   -43.415 -28.091 1.00 29.75  ? 700  TRP A CD1 1 
ATOM   3152 C  CD2 . TRP A 1 437 ? 2.006   -45.451 -27.329 1.00 28.20  ? 700  TRP A CD2 1 
ATOM   3153 N  NE1 . TRP A 1 437 ? 1.461   -43.368 -26.719 1.00 32.55  ? 700  TRP A NE1 1 
ATOM   3154 C  CE2 . TRP A 1 437 ? 1.731   -44.613 -26.225 1.00 28.69  ? 700  TRP A CE2 1 
ATOM   3155 C  CE3 . TRP A 1 437 ? 2.319   -46.786 -27.122 1.00 28.28  ? 700  TRP A CE3 1 
ATOM   3156 C  CZ2 . TRP A 1 437 ? 1.773   -45.066 -24.918 1.00 26.52  ? 700  TRP A CZ2 1 
ATOM   3157 C  CZ3 . TRP A 1 437 ? 2.366   -47.238 -25.826 1.00 30.94  ? 700  TRP A CZ3 1 
ATOM   3158 C  CH2 . TRP A 1 437 ? 2.114   -46.381 -24.750 1.00 30.35  ? 700  TRP A CH2 1 
ATOM   3159 N  N   . ASN A 1 438 ? 4.071   -46.476 -32.170 1.00 30.88  ? 701  ASN A N   1 
ATOM   3160 C  CA  . ASN A 1 438 ? 4.253   -47.015 -33.530 1.00 35.87  ? 701  ASN A CA  1 
ATOM   3161 C  C   . ASN A 1 438 ? 3.042   -47.827 -33.943 1.00 35.76  ? 701  ASN A C   1 
ATOM   3162 O  O   . ASN A 1 438 ? 2.943   -48.081 -35.141 1.00 42.04  ? 701  ASN A O   1 
ATOM   3163 C  CB  . ASN A 1 438 ? 5.516   -47.872 -33.575 1.00 40.20  ? 701  ASN A CB  1 
ATOM   3164 C  CG  . ASN A 1 438 ? 6.711   -47.051 -33.128 1.00 51.79  ? 701  ASN A CG  1 
ATOM   3165 O  OD1 . ASN A 1 438 ? 7.428   -47.406 -32.168 1.00 58.12  ? 701  ASN A OD1 1 
ATOM   3166 N  ND2 . ASN A 1 438 ? 6.851   -45.896 -33.772 1.00 42.23  ? 701  ASN A ND2 1 
ATOM   3167 N  N   . ASP A 1 439 ? 2.188   -48.233 -33.000 1.00 37.46  ? 702  ASP A N   1 
ATOM   3168 C  CA  . ASP A 1 439 ? 1.061   -49.162 -33.302 1.00 42.11  ? 702  ASP A CA  1 
ATOM   3169 C  C   . ASP A 1 439 ? -0.222  -48.585 -32.680 1.00 35.86  ? 702  ASP A C   1 
ATOM   3170 O  O   . ASP A 1 439 ? -0.246  -48.353 -31.460 1.00 33.36  ? 702  ASP A O   1 
ATOM   3171 C  CB  . ASP A 1 439 ? 1.537   -50.562 -32.884 1.00 45.55  ? 702  ASP A CB  1 
ATOM   3172 C  CG  . ASP A 1 439 ? 0.523   -51.688 -32.773 1.00 49.22  ? 702  ASP A CG  1 
ATOM   3173 O  OD1 . ASP A 1 439 ? -0.633  -51.534 -33.257 1.00 40.81  ? 702  ASP A OD1 1 
ATOM   3174 O  OD2 . ASP A 1 439 ? 0.915   -52.726 -32.159 1.00 50.90  ? 702  ASP A OD2 1 
ATOM   3175 N  N   . TRP A 1 440 ? -1.249  -48.345 -33.495 1.00 31.81  ? 703  TRP A N   1 
ATOM   3176 C  CA  . TRP A 1 440 ? -2.538  -47.752 -33.062 1.00 32.07  ? 703  TRP A CA  1 
ATOM   3177 C  C   . TRP A 1 440 ? -3.171  -48.634 -31.970 1.00 30.94  ? 703  TRP A C   1 
ATOM   3178 O  O   . TRP A 1 440 ? -3.896  -48.105 -31.114 1.00 31.71  ? 703  TRP A O   1 
ATOM   3179 C  CB  . TRP A 1 440 ? -3.463  -47.513 -34.259 1.00 32.82  ? 703  TRP A CB  1 
ATOM   3180 C  CG  . TRP A 1 440 ? -3.969  -48.759 -34.935 1.00 35.01  ? 703  TRP A CG  1 
ATOM   3181 C  CD1 . TRP A 1 440 ? -3.422  -49.408 -36.007 1.00 38.18  ? 703  TRP A CD1 1 
ATOM   3182 C  CD2 . TRP A 1 440 ? -5.118  -49.532 -34.564 1.00 35.82  ? 703  TRP A CD2 1 
ATOM   3183 N  NE1 . TRP A 1 440 ? -4.180  -50.495 -36.354 1.00 35.46  ? 703  TRP A NE1 1 
ATOM   3184 C  CE2 . TRP A 1 440 ? -5.201  -50.625 -35.463 1.00 37.21  ? 703  TRP A CE2 1 
ATOM   3185 C  CE3 . TRP A 1 440 ? -6.095  -49.398 -33.577 1.00 32.91  ? 703  TRP A CE3 1 
ATOM   3186 C  CZ2 . TRP A 1 440 ? -6.212  -51.587 -35.393 1.00 36.39  ? 703  TRP A CZ2 1 
ATOM   3187 C  CZ3 . TRP A 1 440 ? -7.103  -50.332 -33.534 1.00 32.95  ? 703  TRP A CZ3 1 
ATOM   3188 C  CH2 . TRP A 1 440 ? -7.149  -51.418 -34.412 1.00 32.80  ? 703  TRP A CH2 1 
ATOM   3189 N  N   . THR A 1 441 ? -2.841  -49.912 -31.919 1.00 30.01  ? 704  THR A N   1 
ATOM   3190 C  CA  . THR A 1 441 ? -3.405  -50.836 -30.889 1.00 30.62  ? 704  THR A CA  1 
ATOM   3191 C  C   . THR A 1 441 ? -2.761  -50.644 -29.511 1.00 28.58  ? 704  THR A C   1 
ATOM   3192 O  O   . THR A 1 441 ? -3.203  -51.290 -28.562 1.00 29.17  ? 704  THR A O   1 
ATOM   3193 C  CB  . THR A 1 441 ? -3.386  -52.307 -31.335 1.00 25.89  ? 704  THR A CB  1 
ATOM   3194 O  OG1 . THR A 1 441 ? -2.040  -52.746 -31.369 1.00 27.96  ? 704  THR A OG1 1 
ATOM   3195 C  CG2 . THR A 1 441 ? -4.019  -52.578 -32.689 1.00 27.70  ? 704  THR A CG2 1 
ATOM   3196 N  N   . GLN A 1 442 ? -1.745  -49.780 -29.408 0.42 29.17  ? 705  GLN A N   1 
ATOM   3197 C  CA  . GLN A 1 442 ? -1.010  -49.492 -28.145 0.42 28.89  ? 705  GLN A CA  1 
ATOM   3198 C  C   . GLN A 1 442 ? -1.349  -48.094 -27.615 0.42 28.36  ? 705  GLN A C   1 
ATOM   3199 O  O   . GLN A 1 442 ? -1.032  -47.833 -26.434 0.42 27.02  ? 705  GLN A O   1 
ATOM   3200 C  CB  . GLN A 1 442 ? 0.492   -49.630 -28.393 0.42 30.21  ? 705  GLN A CB  1 
ATOM   3201 C  CG  . GLN A 1 442 ? 0.842   -50.920 -29.116 0.42 30.97  ? 705  GLN A CG  1 
ATOM   3202 C  CD  . GLN A 1 442 ? 0.417   -52.102 -28.287 0.42 32.54  ? 705  GLN A CD  1 
ATOM   3203 O  OE1 . GLN A 1 442 ? 0.706   -52.162 -27.093 0.42 31.45  ? 705  GLN A OE1 1 
ATOM   3204 N  NE2 . GLN A 1 442 ? -0.283  -53.043 -28.910 0.42 35.35  ? 705  GLN A NE2 1 
ATOM   3205 N  N   . VAL A 1 443 ? -1.934  -47.228 -28.449 1.00 27.72  ? 706  VAL A N   1 
ATOM   3206 C  CA  . VAL A 1 443 ? -2.252  -45.811 -28.079 1.00 30.01  ? 706  VAL A CA  1 
ATOM   3207 C  C   . VAL A 1 443 ? -3.313  -45.751 -26.984 1.00 25.21  ? 706  VAL A C   1 
ATOM   3208 O  O   . VAL A 1 443 ? -4.338  -46.387 -27.105 1.00 27.46  ? 706  VAL A O   1 
ATOM   3209 C  CB  . VAL A 1 443 ? -2.702  -45.016 -29.319 1.00 31.50  ? 706  VAL A CB  1 
ATOM   3210 C  CG1 . VAL A 1 443 ? -3.169  -43.620 -28.962 1.00 36.02  ? 706  VAL A CG1 1 
ATOM   3211 C  CG2 . VAL A 1 443 ? -1.574  -44.945 -30.319 1.00 32.23  ? 706  VAL A CG2 1 
ATOM   3212 N  N   . PRO A 1 444 ? -3.108  -45.004 -25.869 1.00 24.91  ? 707  PRO A N   1 
ATOM   3213 C  CA  . PRO A 1 444 ? -4.169  -44.774 -24.892 1.00 25.42  ? 707  PRO A CA  1 
ATOM   3214 C  C   . PRO A 1 444 ? -5.097  -43.676 -25.416 1.00 25.51  ? 707  PRO A C   1 
ATOM   3215 O  O   . PRO A 1 444 ? -4.623  -42.734 -26.023 1.00 28.03  ? 707  PRO A O   1 
ATOM   3216 C  CB  . PRO A 1 444 ? -3.446  -44.291 -23.641 1.00 27.35  ? 707  PRO A CB  1 
ATOM   3217 C  CG  . PRO A 1 444 ? -2.159  -43.637 -24.186 1.00 26.57  ? 707  PRO A CG  1 
ATOM   3218 C  CD  . PRO A 1 444 ? -1.863  -44.315 -25.518 1.00 25.28  ? 707  PRO A CD  1 
ATOM   3219 N  N   . PHE A 1 445 ? -6.401  -43.829 -25.213 1.00 25.97  ? 708  PHE A N   1 
ATOM   3220 C  CA  . PHE A 1 445 ? -7.407  -42.791 -25.515 1.00 24.68  ? 708  PHE A CA  1 
ATOM   3221 C  C   . PHE A 1 445 ? -8.643  -43.062 -24.683 1.00 25.23  ? 708  PHE A C   1 
ATOM   3222 O  O   . PHE A 1 445 ? -9.132  -44.186 -24.755 1.00 22.11  ? 708  PHE A O   1 
ATOM   3223 C  CB  . PHE A 1 445 ? -7.783  -42.832 -26.997 1.00 25.79  ? 708  PHE A CB  1 
ATOM   3224 C  CG  . PHE A 1 445 ? -8.660  -41.705 -27.507 1.00 27.82  ? 708  PHE A CG  1 
ATOM   3225 C  CD1 . PHE A 1 445 ? -8.416  -40.390 -27.155 1.00 29.03  ? 708  PHE A CD1 1 
ATOM   3226 C  CD2 . PHE A 1 445 ? -9.685  -41.957 -28.421 1.00 31.50  ? 708  PHE A CD2 1 
ATOM   3227 C  CE1 . PHE A 1 445 ? -9.202  -39.354 -27.653 1.00 31.85  ? 708  PHE A CE1 1 
ATOM   3228 C  CE2 . PHE A 1 445 ? -10.449 -40.919 -28.955 1.00 31.45  ? 708  PHE A CE2 1 
ATOM   3229 C  CZ  . PHE A 1 445 ? -10.217 -39.621 -28.554 1.00 33.35  ? 708  PHE A CZ  1 
ATOM   3230 N  N   . CYS A 1 446 ? -9.167  -42.045 -24.000 1.00 25.84  ? 709  CYS A N   1 
ATOM   3231 C  CA  . CYS A 1 446 ? -10.423 -42.140 -23.204 1.00 26.40  ? 709  CYS A CA  1 
ATOM   3232 C  C   . CYS A 1 446 ? -10.356 -43.330 -22.225 1.00 26.04  ? 709  CYS A C   1 
ATOM   3233 O  O   . CYS A 1 446 ? -11.381 -44.034 -22.076 1.00 27.02  ? 709  CYS A O   1 
ATOM   3234 C  CB  . CYS A 1 446 ? -11.645 -42.199 -24.110 1.00 26.24  ? 709  CYS A CB  1 
ATOM   3235 S  SG  . CYS A 1 446 ? -11.868 -40.688 -25.107 1.00 29.32  ? 709  CYS A SG  1 
ATOM   3236 N  N   . SER A 1 447 ? -9.200  -43.534 -21.583 1.00 25.98  ? 710  SER A N   1 
ATOM   3237 C  CA  . SER A 1 447 ? -8.956  -44.543 -20.518 1.00 27.87  ? 710  SER A CA  1 
ATOM   3238 C  C   . SER A 1 447 ? -8.943  -45.975 -21.094 1.00 29.86  ? 710  SER A C   1 
ATOM   3239 O  O   . SER A 1 447 ? -8.963  -46.930 -20.277 1.00 29.11  ? 710  SER A O   1 
ATOM   3240 C  CB  . SER A 1 447 ? -10.011 -44.412 -19.448 1.00 35.03  ? 710  SER A CB  1 
ATOM   3241 O  OG  . SER A 1 447 ? -9.935  -43.143 -18.812 1.00 38.81  ? 710  SER A OG  1 
ATOM   3242 N  N   . HIS A 1 448 ? -8.853  -46.142 -22.424 1.00 26.73  ? 711  HIS A N   1 
ATOM   3243 C  CA  . HIS A 1 448 ? -8.854  -47.456 -23.113 1.00 25.05  ? 711  HIS A CA  1 
ATOM   3244 C  C   . HIS A 1 448 ? -7.640  -47.660 -24.045 1.00 25.58  ? 711  HIS A C   1 
ATOM   3245 O  O   . HIS A 1 448 ? -6.936  -46.654 -24.406 1.00 23.43  ? 711  HIS A O   1 
ATOM   3246 C  CB  . HIS A 1 448 ? -10.146 -47.599 -23.953 1.00 23.83  ? 711  HIS A CB  1 
ATOM   3247 C  CG  . HIS A 1 448 ? -11.347 -47.832 -23.107 1.00 23.95  ? 711  HIS A CG  1 
ATOM   3248 N  ND1 . HIS A 1 448 ? -11.894 -46.836 -22.306 1.00 26.77  ? 711  HIS A ND1 1 
ATOM   3249 C  CD2 . HIS A 1 448 ? -12.053 -48.962 -22.863 1.00 25.97  ? 711  HIS A CD2 1 
ATOM   3250 C  CE1 . HIS A 1 448 ? -12.906 -47.341 -21.624 1.00 25.24  ? 711  HIS A CE1 1 
ATOM   3251 N  NE2 . HIS A 1 448 ? -13.037 -48.666 -21.938 1.00 25.31  ? 711  HIS A NE2 1 
ATOM   3252 N  N   . HIS A 1 449 ? -7.470  -48.907 -24.516 1.00 23.59  ? 712  HIS A N   1 
ATOM   3253 C  CA  . HIS A 1 449 ? -6.725  -49.234 -25.756 1.00 22.41  ? 712  HIS A CA  1 
ATOM   3254 C  C   . HIS A 1 449 ? -7.643  -50.115 -26.586 1.00 23.94  ? 712  HIS A C   1 
ATOM   3255 O  O   . HIS A 1 449 ? -8.708  -50.481 -26.089 1.00 26.71  ? 712  HIS A O   1 
ATOM   3256 C  CB  . HIS A 1 449 ? -5.373  -49.895 -25.501 1.00 21.42  ? 712  HIS A CB  1 
ATOM   3257 C  CG  . HIS A 1 449 ? -5.516  -51.128 -24.675 1.00 23.63  ? 712  HIS A CG  1 
ATOM   3258 N  ND1 . HIS A 1 449 ? -5.695  -51.068 -23.319 1.00 23.48  ? 712  HIS A ND1 1 
ATOM   3259 C  CD2 . HIS A 1 449 ? -5.611  -52.424 -25.013 1.00 22.37  ? 712  HIS A CD2 1 
ATOM   3260 C  CE1 . HIS A 1 449 ? -5.849  -52.289 -22.826 1.00 22.73  ? 712  HIS A CE1 1 
ATOM   3261 N  NE2 . HIS A 1 449 ? -5.793  -53.146 -23.846 1.00 24.75  ? 712  HIS A NE2 1 
ATOM   3262 N  N   . PHE A 1 450 ? -7.237  -50.428 -27.805 1.00 22.97  ? 713  PHE A N   1 
ATOM   3263 C  CA  . PHE A 1 450 ? -8.146  -51.063 -28.775 1.00 23.73  ? 713  PHE A CA  1 
ATOM   3264 C  C   . PHE A 1 450 ? -7.417  -52.240 -29.403 1.00 23.45  ? 713  PHE A C   1 
ATOM   3265 O  O   . PHE A 1 450 ? -6.221  -52.142 -29.761 1.00 24.33  ? 713  PHE A O   1 
ATOM   3266 C  CB  . PHE A 1 450 ? -8.698  -50.018 -29.765 1.00 26.55  ? 713  PHE A CB  1 
ATOM   3267 C  CG  . PHE A 1 450 ? -9.396  -48.891 -29.052 1.00 25.41  ? 713  PHE A CG  1 
ATOM   3268 C  CD1 . PHE A 1 450 ? -8.661  -47.902 -28.421 1.00 27.51  ? 713  PHE A CD1 1 
ATOM   3269 C  CD2 . PHE A 1 450 ? -10.753 -48.948 -28.810 1.00 26.32  ? 713  PHE A CD2 1 
ATOM   3270 C  CE1 . PHE A 1 450 ? -9.303  -46.922 -27.666 1.00 26.81  ? 713  PHE A CE1 1 
ATOM   3271 C  CE2 . PHE A 1 450 ? -11.385 -47.964 -28.070 1.00 29.25  ? 713  PHE A CE2 1 
ATOM   3272 C  CZ  . PHE A 1 450 ? -10.663 -46.943 -27.513 1.00 26.55  ? 713  PHE A CZ  1 
ATOM   3273 N  N   . HIS A 1 451 ? -8.142  -53.360 -29.496 1.00 25.45  ? 714  HIS A N   1 
ATOM   3274 C  CA  . HIS A 1 451 ? -7.660  -54.595 -30.139 1.00 26.22  ? 714  HIS A CA  1 
ATOM   3275 C  C   . HIS A 1 451 ? -8.354  -54.787 -31.484 1.00 27.80  ? 714  HIS A C   1 
ATOM   3276 O  O   . HIS A 1 451 ? -9.540  -54.412 -31.618 1.00 28.11  ? 714  HIS A O   1 
ATOM   3277 C  CB  . HIS A 1 451 ? -7.916  -55.769 -29.200 1.00 26.63  ? 714  HIS A CB  1 
ATOM   3278 C  CG  . HIS A 1 451 ? -7.183  -55.751 -27.898 1.00 25.79  ? 714  HIS A CG  1 
ATOM   3279 N  ND1 . HIS A 1 451 ? -6.086  -56.528 -27.689 1.00 26.31  ? 714  HIS A ND1 1 
ATOM   3280 C  CD2 . HIS A 1 451 ? -7.441  -55.143 -26.705 1.00 27.31  ? 714  HIS A CD2 1 
ATOM   3281 C  CE1 . HIS A 1 451 ? -5.691  -56.401 -26.411 1.00 28.11  ? 714  HIS A CE1 1 
ATOM   3282 N  NE2 . HIS A 1 451 ? -6.530  -55.579 -25.774 1.00 20.50  ? 714  HIS A NE2 1 
ATOM   3283 N  N   . GLU A 1 452 ? -7.643  -55.408 -32.417 1.00 32.07  ? 715  GLU A N   1 
ATOM   3284 C  CA  . GLU A 1 452 ? -8.195  -55.939 -33.676 1.00 35.88  ? 715  GLU A CA  1 
ATOM   3285 C  C   . GLU A 1 452 ? -8.503  -57.431 -33.479 1.00 37.93  ? 715  GLU A C   1 
ATOM   3286 O  O   . GLU A 1 452 ? -7.633  -58.170 -33.115 1.00 38.86  ? 715  GLU A O   1 
ATOM   3287 C  CB  . GLU A 1 452 ? -7.205  -55.702 -34.802 1.00 36.64  ? 715  GLU A CB  1 
ATOM   3288 C  CG  . GLU A 1 452 ? -7.912  -55.300 -36.077 1.00 41.46  ? 715  GLU A CG  1 
ATOM   3289 C  CD  . GLU A 1 452 ? -6.987  -54.951 -37.231 1.00 45.13  ? 715  GLU A CD  1 
ATOM   3290 O  OE1 . GLU A 1 452 ? -7.428  -54.205 -38.152 1.00 43.97  ? 715  GLU A OE1 1 
ATOM   3291 O  OE2 . GLU A 1 452 ? -5.849  -55.450 -37.213 1.00 52.35  ? 715  GLU A OE2 1 
ATOM   3292 N  N   . LEU A 1 453 ? -9.749  -57.836 -33.656 1.00 33.21  ? 716  LEU A N   1 
ATOM   3293 C  CA  . LEU A 1 453 ? -10.221 -59.186 -33.295 1.00 35.79  ? 716  LEU A CA  1 
ATOM   3294 C  C   . LEU A 1 453 ? -10.921 -59.754 -34.526 1.00 34.79  ? 716  LEU A C   1 
ATOM   3295 O  O   . LEU A 1 453 ? -11.877 -59.106 -35.039 1.00 33.64  ? 716  LEU A O   1 
ATOM   3296 C  CB  . LEU A 1 453 ? -11.113 -58.972 -32.083 1.00 38.31  ? 716  LEU A CB  1 
ATOM   3297 C  CG  . LEU A 1 453 ? -11.835 -60.165 -31.512 1.00 44.69  ? 716  LEU A CG  1 
ATOM   3298 C  CD1 . LEU A 1 453 ? -10.867 -61.270 -31.147 1.00 48.60  ? 716  LEU A CD1 1 
ATOM   3299 C  CD2 . LEU A 1 453 ? -12.626 -59.722 -30.295 1.00 44.93  ? 716  LEU A CD2 1 
ATOM   3300 N  N   . ILE A 1 454 ? -10.363 -60.829 -35.085 1.00 34.37  ? 717  ILE A N   1 
ATOM   3301 C  CA  . ILE A 1 454 ? -10.921 -61.427 -36.342 1.00 36.42  ? 717  ILE A CA  1 
ATOM   3302 C  C   . ILE A 1 454 ? -11.930 -62.506 -35.943 1.00 35.36  ? 717  ILE A C   1 
ATOM   3303 O  O   . ILE A 1 454 ? -11.651 -63.302 -35.030 1.00 36.63  ? 717  ILE A O   1 
ATOM   3304 C  CB  . ILE A 1 454 ? -9.800  -61.912 -37.287 1.00 43.66  ? 717  ILE A CB  1 
ATOM   3305 C  CG1 . ILE A 1 454 ? -8.869  -60.754 -37.677 1.00 39.87  ? 717  ILE A CG1 1 
ATOM   3306 C  CG2 . ILE A 1 454 ? -10.387 -62.565 -38.537 1.00 46.50  ? 717  ILE A CG2 1 
ATOM   3307 C  CD1 . ILE A 1 454 ? -7.613  -61.195 -38.343 1.00 45.10  ? 717  ILE A CD1 1 
ATOM   3308 N  N   . MET A 1 455 ? -13.134 -62.420 -36.488 1.00 35.40  ? 718  MET A N   1 
ATOM   3309 C  CA  . MET A 1 455 ? -14.193 -63.437 -36.240 1.00 40.27  ? 718  MET A CA  1 
ATOM   3310 C  C   . MET A 1 455 ? -13.951 -64.666 -37.129 1.00 39.30  ? 718  MET A C   1 
ATOM   3311 O  O   . MET A 1 455 ? -13.406 -64.522 -38.243 1.00 38.25  ? 718  MET A O   1 
ATOM   3312 C  CB  . MET A 1 455 ? -15.575 -62.873 -36.579 1.00 39.70  ? 718  MET A CB  1 
ATOM   3313 C  CG  . MET A 1 455 ? -15.990 -61.726 -35.701 1.00 39.59  ? 718  MET A CG  1 
ATOM   3314 S  SD  . MET A 1 455 ? -17.509 -60.957 -36.311 1.00 38.86  ? 718  MET A SD  1 
ATOM   3315 C  CE  . MET A 1 455 ? -18.692 -62.170 -35.746 1.00 42.35  ? 718  MET A CE  1 
ATOM   3316 N  N   A LYS A 1 456 ? -14.380 -65.836 -36.656 0.25 39.64  ? 719  LYS A N   1 
ATOM   3317 N  N   B LYS A 1 456 ? -14.384 -65.834 -36.649 0.25 40.74  ? 719  LYS A N   1 
ATOM   3318 C  CA  A LYS A 1 456 ? -14.278 -67.135 -37.377 0.25 42.86  ? 719  LYS A CA  1 
ATOM   3319 C  CA  B LYS A 1 456 ? -14.314 -67.139 -37.363 0.25 44.70  ? 719  LYS A CA  1 
ATOM   3320 C  C   A LYS A 1 456 ? -14.700 -66.958 -38.845 0.25 41.82  ? 719  LYS A C   1 
ATOM   3321 C  C   B LYS A 1 456 ? -14.691 -66.946 -38.841 0.25 42.79  ? 719  LYS A C   1 
ATOM   3322 O  O   A LYS A 1 456 ? -14.113 -67.643 -39.697 0.25 43.34  ? 719  LYS A O   1 
ATOM   3323 O  O   B LYS A 1 456 ? -14.069 -67.606 -39.688 0.25 43.87  ? 719  LYS A O   1 
ATOM   3324 C  CB  A LYS A 1 456 ? -15.089 -68.199 -36.629 0.25 43.90  ? 719  LYS A CB  1 
ATOM   3325 C  CB  B LYS A 1 456 ? -15.205 -68.168 -36.658 0.25 47.29  ? 719  LYS A CB  1 
ATOM   3326 C  CG  A LYS A 1 456 ? -14.327 -68.897 -35.508 0.25 44.08  ? 719  LYS A CG  1 
ATOM   3327 C  CG  B LYS A 1 456 ? -15.183 -69.560 -37.275 0.25 50.23  ? 719  LYS A CG  1 
ATOM   3328 C  CD  A LYS A 1 456 ? -15.178 -69.816 -34.657 0.25 45.83  ? 719  LYS A CD  1 
ATOM   3329 C  CD  B LYS A 1 456 ? -15.048 -70.695 -36.269 0.25 49.95  ? 719  LYS A CD  1 
ATOM   3330 C  CE  A LYS A 1 456 ? -15.776 -69.133 -33.443 0.25 45.95  ? 719  LYS A CE  1 
ATOM   3331 C  CE  B LYS A 1 456 ? -15.333 -72.057 -36.874 0.25 49.22  ? 719  LYS A CE  1 
ATOM   3332 N  NZ  A LYS A 1 456 ? -17.005 -69.817 -32.975 0.25 45.32  ? 719  LYS A NZ  1 
ATOM   3333 N  NZ  B LYS A 1 456 ? -14.585 -73.139 -36.190 0.25 47.41  ? 719  LYS A NZ  1 
ATOM   3334 N  N   . ASP A 1 457 ? -15.623 -66.037 -39.141 1.00 41.65  ? 720  ASP A N   1 
ATOM   3335 C  CA  . ASP A 1 457 ? -16.071 -65.755 -40.548 1.00 42.13  ? 720  ASP A CA  1 
ATOM   3336 C  C   . ASP A 1 457 ? -15.227 -64.684 -41.270 1.00 49.83  ? 720  ASP A C   1 
ATOM   3337 O  O   . ASP A 1 457 ? -15.618 -64.259 -42.390 1.00 46.16  ? 720  ASP A O   1 
ATOM   3338 C  CB  . ASP A 1 457 ? -17.558 -65.377 -40.560 1.00 47.07  ? 720  ASP A CB  1 
ATOM   3339 C  CG  . ASP A 1 457 ? -17.923 -64.179 -39.700 1.00 46.92  ? 720  ASP A CG  1 
ATOM   3340 O  OD1 . ASP A 1 457 ? -17.077 -63.282 -39.562 1.00 46.31  ? 720  ASP A OD1 1 
ATOM   3341 O  OD2 . ASP A 1 457 ? -19.062 -64.123 -39.226 1.00 43.31  ? 720  ASP A OD2 1 
ATOM   3342 N  N   . GLY A 1 458 ? -14.116 -64.237 -40.668 1.00 53.07  ? 721  GLY A N   1 
ATOM   3343 C  CA  . GLY A 1 458 ? -13.162 -63.302 -41.283 1.00 49.47  ? 721  GLY A CA  1 
ATOM   3344 C  C   . GLY A 1 458 ? -13.560 -61.836 -41.127 1.00 51.15  ? 721  GLY A C   1 
ATOM   3345 O  O   . GLY A 1 458 ? -12.804 -60.962 -41.554 1.00 46.81  ? 721  GLY A O   1 
ATOM   3346 N  N   . ARG A 1 459 ? -14.719 -61.505 -40.568 1.00 44.63  ? 722  ARG A N   1 
ATOM   3347 C  CA  . ARG A 1 459 ? -15.046 -60.071 -40.416 1.00 36.69  ? 722  ARG A CA  1 
ATOM   3348 C  C   . ARG A 1 459 ? -14.193 -59.513 -39.242 1.00 39.76  ? 722  ARG A C   1 
ATOM   3349 O  O   . ARG A 1 459 ? -13.791 -60.254 -38.312 1.00 36.66  ? 722  ARG A O   1 
ATOM   3350 C  CB  . ARG A 1 459 ? -16.566 -59.907 -40.316 1.00 41.82  ? 722  ARG A CB  1 
ATOM   3351 C  CG  . ARG A 1 459 ? -17.353 -60.238 -41.587 1.00 37.60  ? 722  ARG A CG  1 
ATOM   3352 C  CD  . ARG A 1 459 ? -18.858 -60.032 -41.439 1.00 35.64  ? 722  ARG A CD  1 
ATOM   3353 N  NE  . ARG A 1 459 ? -19.387 -60.841 -40.353 1.00 36.29  ? 722  ARG A NE  1 
ATOM   3354 C  CZ  . ARG A 1 459 ? -20.659 -60.906 -40.002 1.00 39.21  ? 722  ARG A CZ  1 
ATOM   3355 N  NH1 . ARG A 1 459 ? -21.544 -60.182 -40.663 1.00 41.29  ? 722  ARG A NH1 1 
ATOM   3356 N  NH2 . ARG A 1 459 ? -21.041 -61.710 -39.012 1.00 39.10  ? 722  ARG A NH2 1 
ATOM   3357 N  N   . VAL A 1 460 ? -13.906 -58.223 -39.286 1.00 39.34  ? 723  VAL A N   1 
ATOM   3358 C  CA  . VAL A 1 460 ? -12.958 -57.564 -38.346 1.00 35.12  ? 723  VAL A CA  1 
ATOM   3359 C  C   . VAL A 1 460 ? -13.704 -56.715 -37.336 1.00 29.87  ? 723  VAL A C   1 
ATOM   3360 O  O   . VAL A 1 460 ? -14.414 -55.745 -37.747 1.00 34.41  ? 723  VAL A O   1 
ATOM   3361 C  CB  . VAL A 1 460 ? -11.932 -56.723 -39.114 1.00 39.89  ? 723  VAL A CB  1 
ATOM   3362 C  CG1 . VAL A 1 460 ? -10.884 -56.182 -38.152 1.00 47.87  ? 723  VAL A CG1 1 
ATOM   3363 C  CG2 . VAL A 1 460 ? -11.269 -57.556 -40.205 1.00 39.01  ? 723  VAL A CG2 1 
ATOM   3364 N  N   . LEU A 1 461 ? -13.496 -57.009 -36.049 1.00 29.13  ? 724  LEU A N   1 
ATOM   3365 C  CA  . LEU A 1 461 ? -13.992 -56.171 -34.932 1.00 27.77  ? 724  LEU A CA  1 
ATOM   3366 C  C   . LEU A 1 461 ? -12.812 -55.357 -34.383 1.00 30.85  ? 724  LEU A C   1 
ATOM   3367 O  O   . LEU A 1 461 ? -11.706 -55.911 -34.221 1.00 32.80  ? 724  LEU A O   1 
ATOM   3368 C  CB  . LEU A 1 461 ? -14.589 -57.084 -33.854 1.00 31.93  ? 724  LEU A CB  1 
ATOM   3369 C  CG  . LEU A 1 461 ? -15.757 -57.959 -34.339 1.00 30.17  ? 724  LEU A CG  1 
ATOM   3370 C  CD1 . LEU A 1 461 ? -16.047 -59.043 -33.364 1.00 32.83  ? 724  LEU A CD1 1 
ATOM   3371 C  CD2 . LEU A 1 461 ? -16.998 -57.161 -34.598 1.00 27.44  ? 724  LEU A CD2 1 
ATOM   3372 N  N   . VAL A 1 462 ? -13.037 -54.086 -34.065 1.00 28.29  ? 725  VAL A N   1 
ATOM   3373 C  CA  . VAL A 1 462 ? -12.073 -53.255 -33.310 1.00 24.55  ? 725  VAL A CA  1 
ATOM   3374 C  C   . VAL A 1 462 ? -12.751 -52.908 -31.999 1.00 23.70  ? 725  VAL A C   1 
ATOM   3375 O  O   . VAL A 1 462 ? -13.794 -52.244 -32.031 1.00 23.68  ? 725  VAL A O   1 
ATOM   3376 C  CB  . VAL A 1 462 ? -11.639 -52.004 -34.083 1.00 27.23  ? 725  VAL A CB  1 
ATOM   3377 C  CG1 . VAL A 1 462 ? -10.701 -51.184 -33.197 1.00 26.30  ? 725  VAL A CG1 1 
ATOM   3378 C  CG2 . VAL A 1 462 ? -10.961 -52.390 -35.397 1.00 26.71  ? 725  VAL A CG2 1 
ATOM   3379 N  N   . VAL A 1 463 ? -12.231 -53.482 -30.917 1.00 24.63  ? 726  VAL A N   1 
ATOM   3380 C  CA  . VAL A 1 463 ? -12.930 -53.577 -29.623 1.00 23.68  ? 726  VAL A CA  1 
ATOM   3381 C  C   . VAL A 1 463 ? -12.194 -52.723 -28.592 1.00 22.23  ? 726  VAL A C   1 
ATOM   3382 O  O   . VAL A 1 463 ? -10.962 -52.681 -28.568 1.00 25.30  ? 726  VAL A O   1 
ATOM   3383 C  CB  . VAL A 1 463 ? -13.066 -55.046 -29.186 1.00 23.46  ? 726  VAL A CB  1 
ATOM   3384 C  CG1 . VAL A 1 463 ? -13.922 -55.830 -30.175 1.00 26.41  ? 726  VAL A CG1 1 
ATOM   3385 C  CG2 . VAL A 1 463 ? -11.705 -55.714 -28.976 1.00 23.22  ? 726  VAL A CG2 1 
ATOM   3386 N  N   . PRO A 1 464 ? -12.933 -52.117 -27.650 1.00 20.87  ? 727  PRO A N   1 
ATOM   3387 C  CA  . PRO A 1 464 ? -12.310 -51.351 -26.582 1.00 22.07  ? 727  PRO A CA  1 
ATOM   3388 C  C   . PRO A 1 464 ? -11.865 -52.241 -25.436 1.00 21.89  ? 727  PRO A C   1 
ATOM   3389 O  O   . PRO A 1 464 ? -12.475 -53.251 -25.243 1.00 22.46  ? 727  PRO A O   1 
ATOM   3390 C  CB  . PRO A 1 464 ? -13.483 -50.492 -26.119 1.00 23.20  ? 727  PRO A CB  1 
ATOM   3391 C  CG  . PRO A 1 464 ? -14.684 -51.404 -26.259 1.00 23.65  ? 727  PRO A CG  1 
ATOM   3392 C  CD  . PRO A 1 464 ? -14.397 -52.159 -27.550 1.00 22.14  ? 727  PRO A CD  1 
ATOM   3393 N  N   . CYS A 1 465 ? -10.840 -51.834 -24.687 1.00 23.17  ? 728  CYS A N   1 
ATOM   3394 C  CA  . CYS A 1 465 ? -10.250 -52.696 -23.628 1.00 23.14  ? 728  CYS A CA  1 
ATOM   3395 C  C   . CYS A 1 465 ? -9.574  -51.826 -22.558 1.00 25.24  ? 728  CYS A C   1 
ATOM   3396 O  O   . CYS A 1 465 ? -9.098  -50.757 -22.883 1.00 22.21  ? 728  CYS A O   1 
ATOM   3397 C  CB  . CYS A 1 465 ? -9.263  -53.715 -24.204 1.00 22.63  ? 728  CYS A CB  1 
ATOM   3398 S  SG  . CYS A 1 465 ? -8.765  -55.028 -23.028 1.00 24.63  ? 728  CYS A SG  1 
ATOM   3399 N  N   . ARG A 1 466 ? -9.540  -52.286 -21.313 1.00 24.81  ? 729  ARG A N   1 
ATOM   3400 C  CA  . ARG A 1 466 ? -8.630  -51.727 -20.309 1.00 24.15  ? 729  ARG A CA  1 
ATOM   3401 C  C   . ARG A 1 466 ? -8.398  -52.791 -19.242 1.00 24.24  ? 729  ARG A C   1 
ATOM   3402 O  O   . ARG A 1 466 ? -9.006  -53.863 -19.314 1.00 24.67  ? 729  ARG A O   1 
ATOM   3403 C  CB  . ARG A 1 466 ? -9.205  -50.458 -19.716 1.00 29.30  ? 729  ARG A CB  1 
ATOM   3404 C  CG  . ARG A 1 466 ? -10.588 -50.620 -19.143 1.00 32.37  ? 729  ARG A CG  1 
ATOM   3405 C  CD  . ARG A 1 466 ? -11.266 -49.290 -18.806 1.00 33.36  ? 729  ARG A CD  1 
ATOM   3406 N  NE  . ARG A 1 466 ? -10.684 -48.597 -17.679 1.00 31.44  ? 729  ARG A NE  1 
ATOM   3407 C  CZ  . ARG A 1 466 ? -11.190 -47.484 -17.148 1.00 35.00  ? 729  ARG A CZ  1 
ATOM   3408 N  NH1 . ARG A 1 466 ? -12.308 -46.938 -17.610 1.00 39.24  ? 729  ARG A NH1 1 
ATOM   3409 N  NH2 . ARG A 1 466 ? -10.546 -46.892 -16.176 1.00 33.20  ? 729  ARG A NH2 1 
ATOM   3410 N  N   . ASN A 1 467 ? -7.473  -52.523 -18.337 1.00 24.46  ? 730  ASN A N   1 
ATOM   3411 C  CA  . ASN A 1 467 ? -7.070  -53.516 -17.324 1.00 25.72  ? 730  ASN A CA  1 
ATOM   3412 C  C   . ASN A 1 467 ? -8.355  -53.973 -16.628 1.00 24.49  ? 730  ASN A C   1 
ATOM   3413 O  O   . ASN A 1 467 ? -9.109  -53.138 -16.134 1.00 25.27  ? 730  ASN A O   1 
ATOM   3414 C  CB  . ASN A 1 467 ? -5.992  -52.969 -16.390 1.00 26.67  ? 730  ASN A CB  1 
ATOM   3415 C  CG  . ASN A 1 467 ? -5.725  -53.979 -15.306 1.00 29.49  ? 730  ASN A CG  1 
ATOM   3416 O  OD1 . ASN A 1 467 ? -6.472  -54.043 -14.349 1.00 27.51  ? 730  ASN A OD1 1 
ATOM   3417 N  ND2 . ASN A 1 467 ? -4.766  -54.868 -15.543 1.00 36.07  ? 730  ASN A ND2 1 
ATOM   3418 N  N   . GLN A 1 468 ? -8.545  -55.272 -16.520 1.00 24.62  ? 731  GLN A N   1 
ATOM   3419 C  CA  . GLN A 1 468 ? -9.824  -55.827 -16.032 1.00 26.00  ? 731  GLN A CA  1 
ATOM   3420 C  C   . GLN A 1 468 ? -10.042 -55.526 -14.549 1.00 25.69  ? 731  GLN A C   1 
ATOM   3421 O  O   . GLN A 1 468 ? -11.223 -55.499 -14.114 1.00 21.25  ? 731  GLN A O   1 
ATOM   3422 C  CB  . GLN A 1 468 ? -9.891  -57.310 -16.320 1.00 28.10  ? 731  GLN A CB  1 
ATOM   3423 C  CG  . GLN A 1 468 ? -11.282 -57.889 -16.158 1.00 25.79  ? 731  GLN A CG  1 
ATOM   3424 C  CD  . GLN A 1 468 ? -11.196 -59.374 -16.379 1.00 26.62  ? 731  GLN A CD  1 
ATOM   3425 O  OE1 . GLN A 1 468 ? -11.520 -59.862 -17.450 1.00 25.98  ? 731  GLN A OE1 1 
ATOM   3426 N  NE2 . GLN A 1 468 ? -10.795 -60.109 -15.361 1.00 24.80  ? 731  GLN A NE2 1 
ATOM   3427 N  N   . ASP A 1 469 ? -8.984  -55.310 -13.786 1.00 25.53  ? 732  ASP A N   1 
ATOM   3428 C  CA  . ASP A 1 469 ? -9.159  -54.901 -12.361 1.00 27.91  ? 732  ASP A CA  1 
ATOM   3429 C  C   . ASP A 1 469 ? -9.961  -53.591 -12.295 1.00 26.88  ? 732  ASP A C   1 
ATOM   3430 O  O   . ASP A 1 469 ? -10.756 -53.440 -11.390 1.00 28.16  ? 732  ASP A O   1 
ATOM   3431 C  CB  . ASP A 1 469 ? -7.820  -54.796 -11.641 1.00 28.39  ? 732  ASP A CB  1 
ATOM   3432 C  CG  . ASP A 1 469 ? -7.127  -56.143 -11.457 1.00 31.57  ? 732  ASP A CG  1 
ATOM   3433 O  OD1 . ASP A 1 469 ? -7.771  -57.203 -11.655 1.00 29.62  ? 732  ASP A OD1 1 
ATOM   3434 O  OD2 . ASP A 1 469 ? -5.954  -56.113 -11.124 1.00 33.63  ? 732  ASP A OD2 1 
ATOM   3435 N  N   . GLU A 1 470 ? -9.719  -52.653 -13.209 1.00 26.50  ? 733  GLU A N   1 
ATOM   3436 C  CA  . GLU A 1 470 ? -10.400 -51.337 -13.264 1.00 26.32  ? 733  GLU A CA  1 
ATOM   3437 C  C   . GLU A 1 470 ? -11.891 -51.539 -13.537 1.00 23.58  ? 733  GLU A C   1 
ATOM   3438 O  O   . GLU A 1 470 ? -12.713 -50.905 -12.840 1.00 23.75  ? 733  GLU A O   1 
ATOM   3439 C  CB  . GLU A 1 470 ? -9.801  -50.449 -14.352 1.00 27.59  ? 733  GLU A CB  1 
ATOM   3440 C  CG  . GLU A 1 470 ? -8.312  -50.188 -14.198 1.00 31.81  ? 733  GLU A CG  1 
ATOM   3441 C  CD  . GLU A 1 470 ? -7.677  -49.384 -15.323 1.00 32.36  ? 733  GLU A CD  1 
ATOM   3442 O  OE1 . GLU A 1 470 ? -6.471  -49.260 -15.316 1.00 41.05  ? 733  GLU A OE1 1 
ATOM   3443 O  OE2 . GLU A 1 470 ? -8.403  -48.896 -16.192 1.00 34.75  ? 733  GLU A OE2 1 
ATOM   3444 N  N   . LEU A 1 471 ? -12.234 -52.415 -14.480 1.00 22.43  ? 734  LEU A N   1 
ATOM   3445 C  CA  . LEU A 1 471 ? -13.633 -52.721 -14.874 1.00 22.32  ? 734  LEU A CA  1 
ATOM   3446 C  C   . LEU A 1 471 ? -14.401 -53.374 -13.707 1.00 22.38  ? 734  LEU A C   1 
ATOM   3447 O  O   . LEU A 1 471 ? -15.548 -52.926 -13.355 1.00 24.18  ? 734  LEU A O   1 
ATOM   3448 C  CB  . LEU A 1 471 ? -13.573 -53.586 -16.139 1.00 21.69  ? 734  LEU A CB  1 
ATOM   3449 C  CG  . LEU A 1 471 ? -13.067 -52.781 -17.341 1.00 26.60  ? 734  LEU A CG  1 
ATOM   3450 C  CD1 . LEU A 1 471 ? -13.019 -53.587 -18.647 1.00 26.50  ? 734  LEU A CD1 1 
ATOM   3451 C  CD2 . LEU A 1 471 ? -13.944 -51.572 -17.534 1.00 28.49  ? 734  LEU A CD2 1 
ATOM   3452 N  N   . ILE A 1 472 ? -13.814 -54.372 -13.079 1.00 22.47  ? 735  ILE A N   1 
ATOM   3453 C  CA  . ILE A 1 472 ? -14.487 -55.080 -11.961 1.00 24.36  ? 735  ILE A CA  1 
ATOM   3454 C  C   . ILE A 1 472 ? -14.590 -54.142 -10.756 1.00 24.42  ? 735  ILE A C   1 
ATOM   3455 O  O   . ILE A 1 472 ? -15.700 -54.094 -10.166 1.00 24.81  ? 735  ILE A O   1 
ATOM   3456 C  CB  . ILE A 1 472 ? -13.782 -56.394 -11.668 1.00 24.23  ? 735  ILE A CB  1 
ATOM   3457 C  CG1 . ILE A 1 472 ? -14.034 -57.312 -12.873 1.00 25.31  ? 735  ILE A CG1 1 
ATOM   3458 C  CG2 . ILE A 1 472 ? -14.297 -57.020 -10.381 1.00 23.81  ? 735  ILE A CG2 1 
ATOM   3459 C  CD1 . ILE A 1 472 ? -13.324 -58.608 -12.779 1.00 28.34  ? 735  ILE A CD1 1 
ATOM   3460 N  N   . GLY A 1 473 ? -13.532 -53.405 -10.447 1.00 21.22  ? 736  GLY A N   1 
ATOM   3461 C  CA  . GLY A 1 473 ? -13.522 -52.489 -9.283  1.00 27.54  ? 736  GLY A CA  1 
ATOM   3462 C  C   . GLY A 1 473 ? -14.593 -51.378 -9.371  1.00 29.82  ? 736  GLY A C   1 
ATOM   3463 O  O   . GLY A 1 473 ? -15.206 -51.038 -8.329  1.00 28.42  ? 736  GLY A O   1 
ATOM   3464 N  N   . ARG A 1 474 ? -14.818 -50.831 -10.571 0.50 28.44  ? 737  ARG A N   1 
ATOM   3465 C  CA  . ARG A 1 474 ? -15.845 -49.784 -10.834 0.50 30.97  ? 737  ARG A CA  1 
ATOM   3466 C  C   . ARG A 1 474 ? -17.253 -50.378 -10.701 0.50 28.73  ? 737  ARG A C   1 
ATOM   3467 O  O   . ARG A 1 474 ? -18.108 -49.716 -10.077 0.50 29.70  ? 737  ARG A O   1 
ATOM   3468 C  CB  . ARG A 1 474 ? -15.663 -49.169 -12.226 0.50 34.43  ? 737  ARG A CB  1 
ATOM   3469 C  CG  . ARG A 1 474 ? -14.328 -48.461 -12.407 0.50 42.36  ? 737  ARG A CG  1 
ATOM   3470 C  CD  . ARG A 1 474 ? -13.955 -48.183 -13.855 0.50 46.80  ? 737  ARG A CD  1 
ATOM   3471 N  NE  . ARG A 1 474 ? -14.455 -46.864 -14.201 0.50 51.99  ? 737  ARG A NE  1 
ATOM   3472 C  CZ  . ARG A 1 474 ? -13.903 -45.735 -13.780 0.50 53.68  ? 737  ARG A CZ  1 
ATOM   3473 N  NH1 . ARG A 1 474 ? -14.436 -44.572 -14.116 0.50 54.02  ? 737  ARG A NH1 1 
ATOM   3474 N  NH2 . ARG A 1 474 ? -12.819 -45.779 -13.023 0.50 54.71  ? 737  ARG A NH2 1 
ATOM   3475 N  N   . ALA A 1 475 ? -17.494 -51.562 -11.270 1.00 25.42  ? 738  ALA A N   1 
ATOM   3476 C  CA  . ALA A 1 475 ? -18.830 -52.215 -11.226 1.00 26.22  ? 738  ALA A CA  1 
ATOM   3477 C  C   . ALA A 1 475 ? -19.197 -52.595 -9.768  1.00 24.36  ? 738  ALA A C   1 
ATOM   3478 O  O   . ALA A 1 475 ? -20.389 -52.641 -9.453  1.00 24.72  ? 738  ALA A O   1 
ATOM   3479 C  CB  . ALA A 1 475 ? -18.904 -53.373 -12.199 1.00 22.42  ? 738  ALA A CB  1 
ATOM   3480 N  N   . ARG A 1 476 ? -18.225 -52.715 -8.858  1.00 25.56  ? 739  ARG A N   1 
ATOM   3481 C  CA  . ARG A 1 476 ? -18.499 -53.043 -7.430  1.00 27.78  ? 739  ARG A CA  1 
ATOM   3482 C  C   . ARG A 1 476 ? -18.840 -51.790 -6.621  1.00 28.52  ? 739  ARG A C   1 
ATOM   3483 O  O   . ARG A 1 476 ? -19.124 -51.900 -5.435  1.00 26.81  ? 739  ARG A O   1 
ATOM   3484 C  CB  . ARG A 1 476 ? -17.371 -53.883 -6.845  1.00 24.39  ? 739  ARG A CB  1 
ATOM   3485 C  CG  . ARG A 1 476 ? -17.366 -55.296 -7.415  1.00 24.23  ? 739  ARG A CG  1 
ATOM   3486 C  CD  . ARG A 1 476 ? -16.015 -55.999 -7.260  1.00 26.79  ? 739  ARG A CD  1 
ATOM   3487 N  NE  . ARG A 1 476 ? -15.585 -56.265 -5.892  1.00 25.09  ? 739  ARG A NE  1 
ATOM   3488 C  CZ  . ARG A 1 476 ? -15.265 -57.450 -5.350  1.00 24.36  ? 739  ARG A CZ  1 
ATOM   3489 N  NH1 . ARG A 1 476 ? -15.348 -58.585 -6.003  1.00 25.97  ? 739  ARG A NH1 1 
ATOM   3490 N  NH2 . ARG A 1 476 ? -14.802 -57.498 -4.117  1.00 24.58  ? 739  ARG A NH2 1 
ATOM   3491 N  N   . ILE A 1 477 ? -18.902 -50.641 -7.251  1.00 30.22  ? 740  ILE A N   1 
ATOM   3492 C  CA  . ILE A 1 477 ? -19.123 -49.383 -6.504  1.00 38.72  ? 740  ILE A CA  1 
ATOM   3493 C  C   . ILE A 1 477 ? -20.447 -48.775 -6.945  1.00 41.96  ? 740  ILE A C   1 
ATOM   3494 O  O   . ILE A 1 477 ? -20.749 -48.764 -8.135  1.00 35.98  ? 740  ILE A O   1 
ATOM   3495 C  CB  . ILE A 1 477 ? -17.949 -48.421 -6.720  1.00 41.13  ? 740  ILE A CB  1 
ATOM   3496 C  CG1 . ILE A 1 477 ? -16.693 -48.896 -5.976  1.00 40.33  ? 740  ILE A CG1 1 
ATOM   3497 C  CG2 . ILE A 1 477 ? -18.362 -47.016 -6.317  1.00 47.70  ? 740  ILE A CG2 1 
ATOM   3498 C  CD1 . ILE A 1 477 ? -15.427 -48.103 -6.328  1.00 42.83  ? 740  ILE A CD1 1 
ATOM   3499 N  N   A SER A 1 478 ? -21.213 -48.287 -5.968  0.15 47.39  ? 741  SER A N   1 
ATOM   3500 N  N   B SER A 1 478 ? -21.245 -48.307 -5.982  0.15 45.86  ? 741  SER A N   1 
ATOM   3501 C  CA  A SER A 1 478 ? -22.438 -47.464 -6.152  0.15 53.64  ? 741  SER A CA  1 
ATOM   3502 C  CA  B SER A 1 478 ? -22.438 -47.450 -6.224  0.15 50.87  ? 741  SER A CA  1 
ATOM   3503 C  C   A SER A 1 478 ? -22.187 -46.063 -5.578  0.15 58.41  ? 741  SER A C   1 
ATOM   3504 C  C   B SER A 1 478 ? -22.221 -46.078 -5.575  0.15 56.72  ? 741  SER A C   1 
ATOM   3505 O  O   A SER A 1 478 ? -21.424 -45.955 -4.588  0.15 60.62  ? 741  SER A O   1 
ATOM   3506 O  O   B SER A 1 478 ? -21.525 -46.009 -4.535  0.15 59.57  ? 741  SER A O   1 
ATOM   3507 C  CB  A SER A 1 478 ? -23.626 -48.131 -5.506  0.15 53.79  ? 741  SER A CB  1 
ATOM   3508 C  CB  B SER A 1 478 ? -23.716 -48.104 -5.751  0.15 49.24  ? 741  SER A CB  1 
ATOM   3509 O  OG  A SER A 1 478 ? -24.761 -47.281 -5.523  0.15 55.36  ? 741  SER A OG  1 
ATOM   3510 O  OG  B SER A 1 478 ? -23.476 -49.026 -4.699  0.15 47.50  ? 741  SER A OG  1 
ATOM   3511 N  N   . GLN A 1 479 ? -22.772 -45.031 -6.195  1.00 62.28  ? 742  GLN A N   1 
ATOM   3512 C  CA  . GLN A 1 479 ? -22.735 -43.639 -5.660  1.00 70.99  ? 742  GLN A CA  1 
ATOM   3513 C  C   . GLN A 1 479 ? -24.106 -43.377 -5.035  1.00 71.67  ? 742  GLN A C   1 
ATOM   3514 O  O   . GLN A 1 479 ? -25.112 -43.676 -5.710  1.00 57.27  ? 742  GLN A O   1 
ATOM   3515 C  CB  . GLN A 1 479 ? -22.415 -42.596 -6.738  1.00 76.15  ? 742  GLN A CB  1 
ATOM   3516 C  CG  . GLN A 1 479 ? -21.039 -42.749 -7.384  1.00 85.66  ? 742  GLN A CG  1 
ATOM   3517 C  CD  . GLN A 1 479 ? -19.859 -42.810 -6.434  1.00 85.86  ? 742  GLN A CD  1 
ATOM   3518 O  OE1 . GLN A 1 479 ? -19.914 -42.359 -5.289  1.00 74.61  ? 742  GLN A OE1 1 
ATOM   3519 N  NE2 . GLN A 1 479 ? -18.755 -43.363 -6.919  1.00 79.08  ? 742  GLN A NE2 1 
ATOM   3520 N  N   . GLY A 1 480 ? -24.125 -42.906 -3.784  1.00 72.04  ? 743  GLY A N   1 
ATOM   3521 C  CA  . GLY A 1 480 ? -25.335 -42.415 -3.100  1.00 69.84  ? 743  GLY A CA  1 
ATOM   3522 C  C   . GLY A 1 480 ? -25.866 -43.379 -2.056  1.00 68.22  ? 743  GLY A C   1 
ATOM   3523 O  O   . GLY A 1 480 ? -25.351 -44.510 -1.944  1.00 77.71  ? 743  GLY A O   1 
ATOM   3524 N  N   . ALA A 1 481 ? -26.855 -42.889 -1.305  1.00 70.43  ? 744  ALA A N   1 
ATOM   3525 C  CA  . ALA A 1 481 ? -27.574 -43.551 -0.198  1.00 67.49  ? 744  ALA A CA  1 
ATOM   3526 C  C   . ALA A 1 481 ? -28.999 -43.882 -0.645  1.00 59.63  ? 744  ALA A C   1 
ATOM   3527 O  O   . ALA A 1 481 ? -29.452 -43.289 -1.632  1.00 47.63  ? 744  ALA A O   1 
ATOM   3528 C  CB  . ALA A 1 481 ? -27.622 -42.620 0.993   1.00 71.10  ? 744  ALA A CB  1 
ATOM   3529 N  N   . GLY A 1 482 ? -29.681 -44.752 0.108   1.00 48.73  ? 745  GLY A N   1 
ATOM   3530 C  CA  . GLY A 1 482 ? -31.119 -45.051 -0.032  1.00 43.88  ? 745  GLY A CA  1 
ATOM   3531 C  C   . GLY A 1 482 ? -31.363 -46.063 -1.127  1.00 44.21  ? 745  GLY A C   1 
ATOM   3532 O  O   . GLY A 1 482 ? -32.517 -46.170 -1.584  1.00 47.27  ? 745  GLY A O   1 
ATOM   3533 N  N   . TRP A 1 483 ? -30.323 -46.787 -1.568  1.00 37.97  ? 746  TRP A N   1 
ATOM   3534 C  CA  . TRP A 1 483 ? -30.498 -47.843 -2.596  1.00 36.91  ? 746  TRP A CA  1 
ATOM   3535 C  C   . TRP A 1 483 ? -31.275 -49.038 -2.010  1.00 35.13  ? 746  TRP A C   1 
ATOM   3536 O  O   . TRP A 1 483 ? -30.800 -49.748 -1.131  1.00 34.49  ? 746  TRP A O   1 
ATOM   3537 C  CB  . TRP A 1 483 ? -29.157 -48.277 -3.173  1.00 46.17  ? 746  TRP A CB  1 
ATOM   3538 C  CG  . TRP A 1 483 ? -28.419 -47.258 -3.982  1.00 52.76  ? 746  TRP A CG  1 
ATOM   3539 C  CD1 . TRP A 1 483 ? -27.627 -46.247 -3.507  1.00 66.63  ? 746  TRP A CD1 1 
ATOM   3540 C  CD2 . TRP A 1 483 ? -28.295 -47.217 -5.410  1.00 46.58  ? 746  TRP A CD2 1 
ATOM   3541 N  NE1 . TRP A 1 483 ? -27.053 -45.554 -4.543  1.00 62.98  ? 746  TRP A NE1 1 
ATOM   3542 C  CE2 . TRP A 1 483 ? -27.457 -46.122 -5.725  1.00 59.94  ? 746  TRP A CE2 1 
ATOM   3543 C  CE3 . TRP A 1 483 ? -28.815 -47.977 -6.451  1.00 47.31  ? 746  TRP A CE3 1 
ATOM   3544 C  CZ2 . TRP A 1 483 ? -27.137 -45.784 -7.039  1.00 55.69  ? 746  TRP A CZ2 1 
ATOM   3545 C  CZ3 . TRP A 1 483 ? -28.510 -47.632 -7.751  1.00 48.95  ? 746  TRP A CZ3 1 
ATOM   3546 C  CH2 . TRP A 1 483 ? -27.693 -46.545 -8.039  1.00 52.31  ? 746  TRP A CH2 1 
ATOM   3547 N  N   . SER A 1 484 ? -32.436 -49.322 -2.547  1.00 32.86  ? 747  SER A N   1 
ATOM   3548 C  CA  . SER A 1 484 ? -33.127 -50.603 -2.299  1.00 31.11  ? 747  SER A CA  1 
ATOM   3549 C  C   . SER A 1 484 ? -32.299 -51.760 -2.896  1.00 30.90  ? 747  SER A C   1 
ATOM   3550 O  O   . SER A 1 484 ? -31.418 -51.491 -3.743  1.00 28.76  ? 747  SER A O   1 
ATOM   3551 C  CB  . SER A 1 484 ? -34.523 -50.523 -2.888  1.00 31.22  ? 747  SER A CB  1 
ATOM   3552 O  OG  . SER A 1 484 ? -34.453 -50.542 -4.308  1.00 27.25  ? 747  SER A OG  1 
ATOM   3553 N  N   . LEU A 1 485 ? -32.638 -53.012 -2.549  1.00 28.03  ? 748  LEU A N   1 
ATOM   3554 C  CA  . LEU A 1 485 ? -32.017 -54.220 -3.153  1.00 29.98  ? 748  LEU A CA  1 
ATOM   3555 C  C   . LEU A 1 485 ? -32.307 -54.245 -4.654  1.00 30.55  ? 748  LEU A C   1 
ATOM   3556 O  O   . LEU A 1 485 ? -31.388 -54.589 -5.434  1.00 31.25  ? 748  LEU A O   1 
ATOM   3557 C  CB  . LEU A 1 485 ? -32.533 -55.486 -2.469  1.00 31.23  ? 748  LEU A CB  1 
ATOM   3558 C  CG  . LEU A 1 485 ? -31.963 -56.788 -3.016  1.00 34.81  ? 748  LEU A CG  1 
ATOM   3559 C  CD1 . LEU A 1 485 ? -30.444 -56.706 -3.063  1.00 37.23  ? 748  LEU A CD1 1 
ATOM   3560 C  CD2 . LEU A 1 485 ? -32.416 -57.965 -2.176  1.00 32.71  ? 748  LEU A CD2 1 
ATOM   3561 N  N   . ARG A 1 486 ? -33.526 -53.882 -5.042  1.00 29.23  ? 749  ARG A N   1 
ATOM   3562 C  CA  . ARG A 1 486 ? -33.968 -53.878 -6.459  1.00 29.73  ? 749  ARG A CA  1 
ATOM   3563 C  C   . ARG A 1 486 ? -33.147 -52.850 -7.235  1.00 27.02  ? 749  ARG A C   1 
ATOM   3564 O  O   . ARG A 1 486 ? -32.724 -53.173 -8.350  1.00 28.29  ? 749  ARG A O   1 
ATOM   3565 C  CB  . ARG A 1 486 ? -35.452 -53.542 -6.593  1.00 31.42  ? 749  ARG A CB  1 
ATOM   3566 C  CG  . ARG A 1 486 ? -35.880 -53.302 -8.039  1.00 30.80  ? 749  ARG A CG  1 
ATOM   3567 C  CD  . ARG A 1 486 ? -37.372 -53.430 -8.107  1.00 30.44  ? 749  ARG A CD  1 
ATOM   3568 N  NE  . ARG A 1 486 ? -37.900 -53.321 -9.469  1.00 31.35  ? 749  ARG A NE  1 
ATOM   3569 C  CZ  . ARG A 1 486 ? -39.049 -53.853 -9.833  1.00 32.45  ? 749  ARG A CZ  1 
ATOM   3570 N  NH1 . ARG A 1 486 ? -39.745 -54.540 -8.937  1.00 31.32  ? 749  ARG A NH1 1 
ATOM   3571 N  NH2 . ARG A 1 486 ? -39.484 -53.723 -11.078 1.00 33.21  ? 749  ARG A NH2 1 
ATOM   3572 N  N   . GLU A 1 487 ? -32.953 -51.654 -6.699  1.00 26.85  ? 750  GLU A N   1 
ATOM   3573 C  CA  . GLU A 1 487 ? -32.174 -50.598 -7.407  1.00 29.29  ? 750  GLU A CA  1 
ATOM   3574 C  C   . GLU A 1 487 ? -30.698 -51.046 -7.541  1.00 31.55  ? 750  GLU A C   1 
ATOM   3575 O  O   . GLU A 1 487 ? -30.069 -50.823 -8.663  1.00 24.39  ? 750  GLU A O   1 
ATOM   3576 C  CB  . GLU A 1 487 ? -32.310 -49.223 -6.741  1.00 39.85  ? 750  GLU A CB  1 
ATOM   3577 C  CG  . GLU A 1 487 ? -32.007 -48.073 -7.711  1.00 51.12  ? 750  GLU A CG  1 
ATOM   3578 C  CD  . GLU A 1 487 ? -32.006 -46.624 -7.186  1.00 66.06  ? 750  GLU A CD  1 
ATOM   3579 O  OE1 . GLU A 1 487 ? -32.296 -46.425 -5.966  1.00 70.41  ? 750  GLU A OE1 1 
ATOM   3580 O  OE2 . GLU A 1 487 ? -31.744 -45.665 -8.016  1.00 59.34  ? 750  GLU A OE2 1 
ATOM   3581 N  N   . THR A 1 488 ? -30.144 -51.683 -6.498  1.00 28.30  ? 751  THR A N   1 
ATOM   3582 C  CA  . THR A 1 488 ? -28.734 -52.178 -6.495  1.00 26.35  ? 751  THR A CA  1 
ATOM   3583 C  C   . THR A 1 488 ? -28.597 -53.255 -7.580  1.00 27.93  ? 751  THR A C   1 
ATOM   3584 O  O   . THR A 1 488 ? -27.579 -53.250 -8.332  1.00 30.98  ? 751  THR A O   1 
ATOM   3585 C  CB  . THR A 1 488 ? -28.390 -52.740 -5.116  1.00 26.77  ? 751  THR A CB  1 
ATOM   3586 O  OG1 . THR A 1 488 ? -28.624 -51.664 -4.200  1.00 28.75  ? 751  THR A OG1 1 
ATOM   3587 C  CG2 . THR A 1 488 ? -26.979 -53.276 -5.058  1.00 25.73  ? 751  THR A CG2 1 
ATOM   3588 N  N   . ALA A 1 489 ? -29.580 -54.160 -7.662  1.00 26.18  ? 752  ALA A N   1 
ATOM   3589 C  CA  . ALA A 1 489 ? -29.601 -55.234 -8.662  1.00 25.59  ? 752  ALA A CA  1 
ATOM   3590 C  C   . ALA A 1 489 ? -29.650 -54.629 -10.077 1.00 26.63  ? 752  ALA A C   1 
ATOM   3591 O  O   . ALA A 1 489 ? -28.911 -55.148 -10.965 1.00 25.28  ? 752  ALA A O   1 
ATOM   3592 C  CB  . ALA A 1 489 ? -30.764 -56.146 -8.397  1.00 26.37  ? 752  ALA A CB  1 
ATOM   3593 N  N   . CYS A 1 490 ? -30.459 -53.580 -10.296 1.00 25.85  ? 753  CYS A N   1 
ATOM   3594 C  CA  . CYS A 1 490 ? -30.656 -52.974 -11.648 1.00 27.01  ? 753  CYS A CA  1 
ATOM   3595 C  C   . CYS A 1 490 ? -29.378 -52.220 -12.060 1.00 26.62  ? 753  CYS A C   1 
ATOM   3596 O  O   . CYS A 1 490 ? -29.052 -52.211 -13.246 1.00 24.94  ? 753  CYS A O   1 
ATOM   3597 C  CB  . CYS A 1 490 ? -31.878 -52.066 -11.695 1.00 28.31  ? 753  CYS A CB  1 
ATOM   3598 S  SG  . CYS A 1 490 ? -33.451 -52.967 -11.620 1.00 30.70  ? 753  CYS A SG  1 
ATOM   3599 N  N   . LEU A 1 491 ? -28.650 -51.630 -11.115 1.00 24.88  ? 754  LEU A N   1 
ATOM   3600 C  CA  . LEU A 1 491 ? -27.310 -51.050 -11.428 1.00 27.73  ? 754  LEU A CA  1 
ATOM   3601 C  C   . LEU A 1 491 ? -26.305 -52.169 -11.785 1.00 30.10  ? 754  LEU A C   1 
ATOM   3602 O  O   . LEU A 1 491 ? -25.532 -52.017 -12.759 1.00 25.44  ? 754  LEU A O   1 
ATOM   3603 C  CB  . LEU A 1 491 ? -26.849 -50.191 -10.241 1.00 28.87  ? 754  LEU A CB  1 
ATOM   3604 C  CG  . LEU A 1 491 ? -25.476 -49.543 -10.424 1.00 29.96  ? 754  LEU A CG  1 
ATOM   3605 C  CD1 . LEU A 1 491 ? -25.465 -48.604 -11.616 1.00 29.31  ? 754  LEU A CD1 1 
ATOM   3606 C  CD2 . LEU A 1 491 ? -25.013 -48.837 -9.154  1.00 28.82  ? 754  LEU A CD2 1 
ATOM   3607 N  N   . GLY A 1 492 ? -26.289 -53.279 -11.039 1.00 28.20  ? 755  GLY A N   1 
ATOM   3608 C  CA  . GLY A 1 492 ? -25.481 -54.433 -11.441 1.00 24.17  ? 755  GLY A CA  1 
ATOM   3609 C  C   . GLY A 1 492 ? -25.733 -54.830 -12.891 1.00 26.64  ? 755  GLY A C   1 
ATOM   3610 O  O   . GLY A 1 492 ? -24.784 -55.121 -13.635 1.00 25.72  ? 755  GLY A O   1 
ATOM   3611 N  N   . LYS A 1 493 ? -26.991 -54.881 -13.294 1.00 23.55  ? 756  LYS A N   1 
ATOM   3612 C  CA  . LYS A 1 493 ? -27.431 -55.369 -14.626 1.00 24.53  ? 756  LYS A CA  1 
ATOM   3613 C  C   . LYS A 1 493 ? -26.941 -54.387 -15.696 1.00 23.43  ? 756  LYS A C   1 
ATOM   3614 O  O   . LYS A 1 493 ? -26.596 -54.855 -16.799 1.00 27.87  ? 756  LYS A O   1 
ATOM   3615 C  CB  . LYS A 1 493 ? -28.968 -55.476 -14.634 1.00 25.80  ? 756  LYS A CB  1 
ATOM   3616 C  CG  . LYS A 1 493 ? -29.580 -56.055 -15.898 1.00 26.58  ? 756  LYS A CG  1 
ATOM   3617 C  CD  . LYS A 1 493 ? -31.069 -56.274 -15.794 1.00 27.80  ? 756  LYS A CD  1 
ATOM   3618 C  CE  . LYS A 1 493 ? -31.682 -56.749 -17.107 1.00 29.32  ? 756  LYS A CE  1 
ATOM   3619 N  NZ  . LYS A 1 493 ? -33.010 -57.376 -16.921 1.00 29.03  ? 756  LYS A NZ  1 
ATOM   3620 N  N   . SER A 1 494 ? -26.972 -53.086 -15.419 1.00 23.98  ? 757  SER A N   1 
ATOM   3621 C  CA  . SER A 1 494 ? -26.405 -52.052 -16.329 1.00 30.39  ? 757  SER A CA  1 
ATOM   3622 C  C   . SER A 1 494 ? -24.929 -52.368 -16.591 1.00 27.81  ? 757  SER A C   1 
ATOM   3623 O  O   . SER A 1 494 ? -24.582 -52.315 -17.741 1.00 23.89  ? 757  SER A O   1 
ATOM   3624 C  CB  . SER A 1 494 ? -26.497 -50.645 -15.832 1.00 30.35  ? 757  SER A CB  1 
ATOM   3625 O  OG  . SER A 1 494 ? -27.831 -50.304 -15.545 1.00 44.47  ? 757  SER A OG  1 
ATOM   3626 N  N   . TYR A 1 495 ? -24.118 -52.633 -15.557 1.00 23.10  ? 758  TYR A N   1 
ATOM   3627 C  CA  . TYR A 1 495 ? -22.679 -53.006 -15.732 1.00 26.24  ? 758  TYR A CA  1 
ATOM   3628 C  C   . TYR A 1 495 ? -22.561 -54.273 -16.579 1.00 26.69  ? 758  TYR A C   1 
ATOM   3629 O  O   . TYR A 1 495 ? -21.773 -54.304 -17.569 1.00 25.51  ? 758  TYR A O   1 
ATOM   3630 C  CB  . TYR A 1 495 ? -21.964 -53.105 -14.373 1.00 25.87  ? 758  TYR A CB  1 
ATOM   3631 C  CG  . TYR A 1 495 ? -21.505 -51.771 -13.864 1.00 26.39  ? 758  TYR A CG  1 
ATOM   3632 C  CD1 . TYR A 1 495 ? -20.431 -51.129 -14.480 1.00 26.60  ? 758  TYR A CD1 1 
ATOM   3633 C  CD2 . TYR A 1 495 ? -22.126 -51.140 -12.797 1.00 28.03  ? 758  TYR A CD2 1 
ATOM   3634 C  CE1 . TYR A 1 495 ? -19.996 -49.888 -14.080 1.00 28.71  ? 758  TYR A CE1 1 
ATOM   3635 C  CE2 . TYR A 1 495 ? -21.678 -49.897 -12.355 1.00 29.00  ? 758  TYR A CE2 1 
ATOM   3636 C  CZ  . TYR A 1 495 ? -20.613 -49.277 -13.000 1.00 35.81  ? 758  TYR A CZ  1 
ATOM   3637 O  OH  . TYR A 1 495 ? -20.146 -48.071 -12.597 1.00 31.18  ? 758  TYR A OH  1 
ATOM   3638 N  N   . ALA A 1 496 ? -23.327 -55.306 -16.207 1.00 27.34  ? 759  ALA A N   1 
ATOM   3639 C  CA  . ALA A 1 496 ? -23.344 -56.598 -16.913 1.00 24.10  ? 759  ALA A CA  1 
ATOM   3640 C  C   . ALA A 1 496 ? -23.656 -56.363 -18.385 1.00 23.80  ? 759  ALA A C   1 
ATOM   3641 O  O   . ALA A 1 496 ? -22.954 -56.957 -19.243 1.00 25.85  ? 759  ALA A O   1 
ATOM   3642 C  CB  . ALA A 1 496 ? -24.361 -57.494 -16.301 1.00 26.56  ? 759  ALA A CB  1 
ATOM   3643 N  N   . GLN A 1 497 ? -24.715 -55.619 -18.710 1.00 23.34  ? 760  GLN A N   1 
ATOM   3644 C  CA  . GLN A 1 497 ? -25.061 -55.443 -20.171 1.00 27.86  ? 760  GLN A CA  1 
ATOM   3645 C  C   . GLN A 1 497 ? -23.972 -54.589 -20.856 1.00 25.65  ? 760  GLN A C   1 
ATOM   3646 O  O   . GLN A 1 497 ? -23.632 -54.891 -22.044 1.00 24.57  ? 760  GLN A O   1 
ATOM   3647 C  CB  . GLN A 1 497 ? -26.502 -54.958 -20.403 1.00 30.22  ? 760  GLN A CB  1 
ATOM   3648 C  CG  . GLN A 1 497 ? -27.543 -55.923 -19.834 1.00 31.03  ? 760  GLN A CG  1 
ATOM   3649 C  CD  . GLN A 1 497 ? -28.997 -55.639 -20.164 1.00 30.02  ? 760  GLN A CD  1 
ATOM   3650 O  OE1 . GLN A 1 497 ? -29.832 -56.538 -20.081 1.00 31.61  ? 760  GLN A OE1 1 
ATOM   3651 N  NE2 . GLN A 1 497 ? -29.325 -54.414 -20.518 1.00 28.21  ? 760  GLN A NE2 1 
ATOM   3652 N  N   . MET A 1 498 ? -23.342 -53.636 -20.139 1.00 23.10  ? 761  MET A N   1 
ATOM   3653 C  CA  . MET A 1 498 ? -22.216 -52.899 -20.767 1.00 25.33  ? 761  MET A CA  1 
ATOM   3654 C  C   . MET A 1 498 ? -21.115 -53.911 -21.132 1.00 23.59  ? 761  MET A C   1 
ATOM   3655 O  O   . MET A 1 498 ? -20.542 -53.852 -22.255 1.00 19.82  ? 761  MET A O   1 
ATOM   3656 C  CB  . MET A 1 498 ? -21.676 -51.777 -19.883 1.00 27.05  ? 761  MET A CB  1 
ATOM   3657 C  CG  . MET A 1 498 ? -20.384 -51.109 -20.445 1.00 29.42  ? 761  MET A CG  1 
ATOM   3658 S  SD  . MET A 1 498 ? -19.878 -49.819 -19.291 1.00 36.96  ? 761  MET A SD  1 
ATOM   3659 C  CE  . MET A 1 498 ? -19.049 -50.780 -18.034 1.00 36.37  ? 761  MET A CE  1 
ATOM   3660 N  N   . TRP A 1 499 ? -20.764 -54.781 -20.194 1.00 20.90  ? 762  TRP A N   1 
ATOM   3661 C  CA  . TRP A 1 499 ? -19.679 -55.748 -20.409 1.00 21.64  ? 762  TRP A CA  1 
ATOM   3662 C  C   . TRP A 1 499 ? -20.012 -56.666 -21.604 1.00 25.47  ? 762  TRP A C   1 
ATOM   3663 O  O   . TRP A 1 499 ? -19.117 -56.956 -22.386 1.00 27.52  ? 762  TRP A O   1 
ATOM   3664 C  CB  . TRP A 1 499 ? -19.433 -56.583 -19.154 1.00 22.82  ? 762  TRP A CB  1 
ATOM   3665 C  CG  . TRP A 1 499 ? -18.828 -55.876 -17.987 1.00 22.41  ? 762  TRP A CG  1 
ATOM   3666 C  CD1 . TRP A 1 499 ? -18.306 -54.625 -17.946 1.00 24.50  ? 762  TRP A CD1 1 
ATOM   3667 C  CD2 . TRP A 1 499 ? -18.647 -56.421 -16.675 1.00 21.69  ? 762  TRP A CD2 1 
ATOM   3668 N  NE1 . TRP A 1 499 ? -17.893 -54.330 -16.680 1.00 26.13  ? 762  TRP A NE1 1 
ATOM   3669 C  CE2 . TRP A 1 499 ? -18.040 -55.428 -15.896 1.00 22.24  ? 762  TRP A CE2 1 
ATOM   3670 C  CE3 . TRP A 1 499 ? -18.980 -57.628 -16.076 1.00 23.43  ? 762  TRP A CE3 1 
ATOM   3671 C  CZ2 . TRP A 1 499 ? -17.726 -55.606 -14.559 1.00 22.49  ? 762  TRP A CZ2 1 
ATOM   3672 C  CZ3 . TRP A 1 499 ? -18.723 -57.792 -14.723 1.00 22.67  ? 762  TRP A CZ3 1 
ATOM   3673 C  CH2 . TRP A 1 499 ? -18.077 -56.809 -13.989 1.00 24.40  ? 762  TRP A CH2 1 
ATOM   3674 N  N   A SER A 1 500 ? -21.261 -57.132 -21.706 0.25 25.32  ? 763  SER A N   1 
ATOM   3675 N  N   B SER A 1 500 ? -21.259 -57.138 -21.730 0.25 24.52  ? 763  SER A N   1 
ATOM   3676 C  CA  A SER A 1 500 ? -21.730 -57.996 -22.820 0.25 25.61  ? 763  SER A CA  1 
ATOM   3677 C  CA  B SER A 1 500 ? -21.655 -58.039 -22.846 0.25 24.30  ? 763  SER A CA  1 
ATOM   3678 C  C   A SER A 1 500 ? -21.565 -57.281 -24.163 0.25 25.07  ? 763  SER A C   1 
ATOM   3679 C  C   B SER A 1 500 ? -21.599 -57.291 -24.185 0.25 24.38  ? 763  SER A C   1 
ATOM   3680 O  O   A SER A 1 500 ? -21.224 -57.953 -25.146 0.25 26.38  ? 763  SER A O   1 
ATOM   3681 O  O   B SER A 1 500 ? -21.349 -57.956 -25.201 0.25 25.91  ? 763  SER A O   1 
ATOM   3682 C  CB  A SER A 1 500 ? -23.146 -58.428 -22.596 0.25 27.30  ? 763  SER A CB  1 
ATOM   3683 C  CB  B SER A 1 500 ? -22.995 -58.700 -22.612 0.25 25.02  ? 763  SER A CB  1 
ATOM   3684 O  OG  A SER A 1 500 ? -23.243 -59.103 -21.352 0.25 29.96  ? 763  SER A OG  1 
ATOM   3685 O  OG  B SER A 1 500 ? -24.063 -57.937 -23.138 0.25 25.26  ? 763  SER A OG  1 
ATOM   3686 N  N   . LEU A 1 501 ? -21.780 -55.966 -24.200 1.00 25.54  ? 764  LEU A N   1 
ATOM   3687 C  CA  . LEU A 1 501 ? -21.715 -55.175 -25.469 1.00 28.68  ? 764  LEU A CA  1 
ATOM   3688 C  C   . LEU A 1 501 ? -20.308 -54.682 -25.856 1.00 29.37  ? 764  LEU A C   1 
ATOM   3689 O  O   . LEU A 1 501 ? -19.973 -54.659 -27.056 1.00 28.02  ? 764  LEU A O   1 
ATOM   3690 C  CB  . LEU A 1 501 ? -22.686 -54.009 -25.311 1.00 35.14  ? 764  LEU A CB  1 
ATOM   3691 C  CG  . LEU A 1 501 ? -23.145 -53.419 -26.629 1.00 45.05  ? 764  LEU A CG  1 
ATOM   3692 C  CD1 . LEU A 1 501 ? -23.727 -54.498 -27.550 1.00 51.14  ? 764  LEU A CD1 1 
ATOM   3693 C  CD2 . LEU A 1 501 ? -24.168 -52.331 -26.341 1.00 54.35  ? 764  LEU A CD2 1 
ATOM   3694 N  N   . MET A 1 502 ? -19.496 -54.271 -24.891 1.00 26.29  ? 765  MET A N   1 
ATOM   3695 C  CA  . MET A 1 502 ? -18.207 -53.584 -25.116 1.00 25.92  ? 765  MET A CA  1 
ATOM   3696 C  C   . MET A 1 502 ? -17.045 -54.545 -24.835 1.00 27.69  ? 765  MET A C   1 
ATOM   3697 O  O   . MET A 1 502 ? -16.064 -54.440 -25.543 1.00 21.98  ? 765  MET A O   1 
ATOM   3698 C  CB  . MET A 1 502 ? -18.112 -52.365 -24.178 1.00 31.29  ? 765  MET A CB  1 
ATOM   3699 C  CG  . MET A 1 502 ? -19.202 -51.294 -24.419 1.00 31.24  ? 765  MET A CG  1 
ATOM   3700 S  SD  . MET A 1 502 ? -19.076 -50.609 -26.099 1.00 35.25  ? 765  MET A SD  1 
ATOM   3701 C  CE  . MET A 1 502 ? -20.354 -51.344 -27.087 1.00 44.65  ? 765  MET A CE  1 
ATOM   3702 N  N   . TYR A 1 503 ? -17.163 -55.418 -23.826 1.00 24.22  ? 766  TYR A N   1 
ATOM   3703 C  CA  . TYR A 1 503 ? -16.025 -56.192 -23.283 1.00 25.85  ? 766  TYR A CA  1 
ATOM   3704 C  C   . TYR A 1 503 ? -16.290 -57.710 -23.382 1.00 26.44  ? 766  TYR A C   1 
ATOM   3705 O  O   . TYR A 1 503 ? -15.725 -58.451 -22.552 1.00 23.82  ? 766  TYR A O   1 
ATOM   3706 C  CB  . TYR A 1 503 ? -15.738 -55.738 -21.850 1.00 27.89  ? 766  TYR A CB  1 
ATOM   3707 C  CG  . TYR A 1 503 ? -15.533 -54.255 -21.643 1.00 27.67  ? 766  TYR A CG  1 
ATOM   3708 C  CD1 . TYR A 1 503 ? -14.558 -53.542 -22.345 1.00 29.25  ? 766  TYR A CD1 1 
ATOM   3709 C  CD2 . TYR A 1 503 ? -16.360 -53.532 -20.795 1.00 30.85  ? 766  TYR A CD2 1 
ATOM   3710 C  CE1 . TYR A 1 503 ? -14.397 -52.170 -22.191 1.00 27.53  ? 766  TYR A CE1 1 
ATOM   3711 C  CE2 . TYR A 1 503 ? -16.212 -52.160 -20.619 1.00 29.45  ? 766  TYR A CE2 1 
ATOM   3712 C  CZ  . TYR A 1 503 ? -15.219 -51.478 -21.312 1.00 29.67  ? 766  TYR A CZ  1 
ATOM   3713 O  OH  . TYR A 1 503 ? -15.063 -50.150 -21.077 1.00 28.80  ? 766  TYR A OH  1 
ATOM   3714 N  N   . PHE A 1 504 ? -17.107 -58.149 -24.356 1.00 26.25  ? 767  PHE A N   1 
ATOM   3715 C  CA  . PHE A 1 504 ? -17.538 -59.555 -24.589 1.00 27.17  ? 767  PHE A CA  1 
ATOM   3716 C  C   . PHE A 1 504 ? -16.314 -60.449 -24.838 1.00 27.68  ? 767  PHE A C   1 
ATOM   3717 O  O   . PHE A 1 504 ? -16.375 -61.697 -24.588 1.00 25.41  ? 767  PHE A O   1 
ATOM   3718 C  CB  . PHE A 1 504 ? -18.462 -59.679 -25.812 1.00 25.22  ? 767  PHE A CB  1 
ATOM   3719 C  CG  . PHE A 1 504 ? -17.987 -58.939 -27.036 1.00 23.26  ? 767  PHE A CG  1 
ATOM   3720 C  CD1 . PHE A 1 504 ? -17.123 -59.534 -27.939 1.00 22.52  ? 767  PHE A CD1 1 
ATOM   3721 C  CD2 . PHE A 1 504 ? -18.358 -57.632 -27.250 1.00 24.19  ? 767  PHE A CD2 1 
ATOM   3722 C  CE1 . PHE A 1 504 ? -16.634 -58.847 -29.035 1.00 20.56  ? 767  PHE A CE1 1 
ATOM   3723 C  CE2 . PHE A 1 504 ? -17.865 -56.945 -28.343 1.00 22.43  ? 767  PHE A CE2 1 
ATOM   3724 C  CZ  . PHE A 1 504 ? -17.010 -57.553 -29.230 1.00 23.47  ? 767  PHE A CZ  1 
ATOM   3725 N  N   . HIS A 1 505 ? -15.253 -59.825 -25.348 1.00 30.11  ? 768  HIS A N   1 
ATOM   3726 C  CA  . HIS A 1 505 ? -13.962 -60.466 -25.759 1.00 28.20  ? 768  HIS A CA  1 
ATOM   3727 C  C   . HIS A 1 505 ? -13.096 -60.841 -24.537 1.00 26.38  ? 768  HIS A C   1 
ATOM   3728 O  O   . HIS A 1 505 ? -12.076 -61.521 -24.718 1.00 25.95  ? 768  HIS A O   1 
ATOM   3729 C  CB  . HIS A 1 505 ? -13.238 -59.572 -26.778 1.00 26.24  ? 768  HIS A CB  1 
ATOM   3730 C  CG  . HIS A 1 505 ? -13.078 -58.171 -26.306 1.00 28.00  ? 768  HIS A CG  1 
ATOM   3731 N  ND1 . HIS A 1 505 ? -12.025 -57.780 -25.540 1.00 25.03  ? 768  HIS A ND1 1 
ATOM   3732 C  CD2 . HIS A 1 505 ? -13.882 -57.090 -26.459 1.00 28.88  ? 768  HIS A CD2 1 
ATOM   3733 C  CE1 . HIS A 1 505 ? -12.177 -56.523 -25.228 1.00 30.03  ? 768  HIS A CE1 1 
ATOM   3734 N  NE2 . HIS A 1 505 ? -13.338 -56.081 -25.765 1.00 27.65  ? 768  HIS A NE2 1 
ATOM   3735 N  N   . ARG A 1 506 ? -13.469 -60.430 -23.328 1.00 23.63  ? 769  ARG A N   1 
ATOM   3736 C  CA  . ARG A 1 506 ? -12.739 -60.748 -22.075 1.00 22.71  ? 769  ARG A CA  1 
ATOM   3737 C  C   . ARG A 1 506 ? -13.516 -61.937 -21.443 1.00 24.14  ? 769  ARG A C   1 
ATOM   3738 O  O   . ARG A 1 506 ? -14.713 -61.775 -21.144 1.00 25.51  ? 769  ARG A O   1 
ATOM   3739 C  CB  . ARG A 1 506 ? -12.682 -59.500 -21.165 1.00 23.60  ? 769  ARG A CB  1 
ATOM   3740 C  CG  . ARG A 1 506 ? -12.180 -58.217 -21.806 1.00 23.50  ? 769  ARG A CG  1 
ATOM   3741 C  CD  . ARG A 1 506 ? -10.834 -58.303 -22.544 1.00 23.65  ? 769  ARG A CD  1 
ATOM   3742 N  NE  . ARG A 1 506 ? -9.955  -58.855 -21.545 1.00 24.10  ? 769  ARG A NE  1 
ATOM   3743 C  CZ  . ARG A 1 506 ? -9.454  -58.214 -20.514 1.00 22.74  ? 769  ARG A CZ  1 
ATOM   3744 N  NH1 . ARG A 1 506 ? -8.722  -58.860 -19.619 1.00 24.79  ? 769  ARG A NH1 1 
ATOM   3745 N  NH2 . ARG A 1 506 ? -9.557  -56.918 -20.428 1.00 25.31  ? 769  ARG A NH2 1 
ATOM   3746 N  N   . ARG A 1 507 ? -12.865 -63.097 -21.295 0.50 24.33  ? 770  ARG A N   1 
ATOM   3747 C  CA  . ARG A 1 507 ? -13.482 -64.364 -20.819 0.50 24.61  ? 770  ARG A CA  1 
ATOM   3748 C  C   . ARG A 1 507 ? -14.176 -64.128 -19.473 0.50 23.80  ? 770  ARG A C   1 
ATOM   3749 O  O   . ARG A 1 507 ? -15.332 -64.536 -19.335 0.50 23.92  ? 770  ARG A O   1 
ATOM   3750 C  CB  . ARG A 1 507 ? -12.434 -65.472 -20.693 0.50 25.64  ? 770  ARG A CB  1 
ATOM   3751 C  CG  . ARG A 1 507 ? -11.902 -65.982 -22.025 0.50 27.12  ? 770  ARG A CG  1 
ATOM   3752 C  CD  . ARG A 1 507 ? -10.595 -66.747 -21.899 0.50 27.36  ? 770  ARG A CD  1 
ATOM   3753 N  NE  . ARG A 1 507 ? -10.237 -67.293 -23.196 0.50 27.84  ? 770  ARG A NE  1 
ATOM   3754 C  CZ  . ARG A 1 507 ? -9.649  -66.588 -24.150 0.50 28.38  ? 770  ARG A CZ  1 
ATOM   3755 N  NH1 . ARG A 1 507 ? -9.320  -65.326 -23.926 0.50 27.78  ? 770  ARG A NH1 1 
ATOM   3756 N  NH2 . ARG A 1 507 ? -9.383  -67.142 -25.315 0.50 27.30  ? 770  ARG A NH2 1 
ATOM   3757 N  N   . ASP A 1 508 ? -13.499 -63.481 -18.527 1.00 24.33  ? 771  ASP A N   1 
ATOM   3758 C  CA  . ASP A 1 508 ? -14.056 -63.281 -17.169 1.00 24.14  ? 771  ASP A CA  1 
ATOM   3759 C  C   . ASP A 1 508 ? -15.294 -62.358 -17.223 1.00 26.54  ? 771  ASP A C   1 
ATOM   3760 O  O   . ASP A 1 508 ? -16.223 -62.569 -16.426 1.00 23.20  ? 771  ASP A O   1 
ATOM   3761 C  CB  . ASP A 1 508 ? -13.002 -62.706 -16.249 1.00 23.54  ? 771  ASP A CB  1 
ATOM   3762 C  CG  . ASP A 1 508 ? -11.819 -63.617 -16.012 1.00 23.47  ? 771  ASP A CG  1 
ATOM   3763 O  OD1 . ASP A 1 508 ? -11.868 -64.777 -16.384 1.00 24.84  ? 771  ASP A OD1 1 
ATOM   3764 O  OD2 . ASP A 1 508 ? -10.885 -63.156 -15.379 1.00 25.24  ? 771  ASP A OD2 1 
ATOM   3765 N  N   . LEU A 1 509 ? -15.332 -61.370 -18.134 1.00 26.33  ? 772  LEU A N   1 
ATOM   3766 C  CA  . LEU A 1 509 ? -16.436 -60.378 -18.123 1.00 24.74  ? 772  LEU A CA  1 
ATOM   3767 C  C   . LEU A 1 509 ? -17.654 -60.974 -18.844 1.00 26.31  ? 772  LEU A C   1 
ATOM   3768 O  O   . LEU A 1 509 ? -18.764 -60.632 -18.473 1.00 24.60  ? 772  LEU A O   1 
ATOM   3769 C  CB  . LEU A 1 509 ? -15.948 -59.048 -18.713 1.00 25.78  ? 772  LEU A CB  1 
ATOM   3770 C  CG  . LEU A 1 509 ? -14.843 -58.317 -17.919 1.00 26.25  ? 772  LEU A CG  1 
ATOM   3771 C  CD1 . LEU A 1 509 ? -14.630 -56.927 -18.474 1.00 26.80  ? 772  LEU A CD1 1 
ATOM   3772 C  CD2 . LEU A 1 509 ? -15.140 -58.301 -16.430 1.00 24.51  ? 772  LEU A CD2 1 
ATOM   3773 N  N   . ARG A 1 510 ? -17.492 -61.843 -19.842 1.00 25.35  ? 773  ARG A N   1 
ATOM   3774 C  CA  . ARG A 1 510 ? -18.694 -62.415 -20.509 1.00 23.91  ? 773  ARG A CA  1 
ATOM   3775 C  C   . ARG A 1 510 ? -19.372 -63.358 -19.509 1.00 26.18  ? 773  ARG A C   1 
ATOM   3776 O  O   . ARG A 1 510 ? -20.603 -63.431 -19.458 1.00 24.49  ? 773  ARG A O   1 
ATOM   3777 C  CB  . ARG A 1 510 ? -18.319 -63.170 -21.781 1.00 23.94  ? 773  ARG A CB  1 
ATOM   3778 C  CG  . ARG A 1 510 ? -19.527 -63.411 -22.688 1.00 25.54  ? 773  ARG A CG  1 
ATOM   3779 C  CD  . ARG A 1 510 ? -19.258 -64.313 -23.881 1.00 25.17  ? 773  ARG A CD  1 
ATOM   3780 N  NE  . ARG A 1 510 ? -18.304 -63.751 -24.808 1.00 23.92  ? 773  ARG A NE  1 
ATOM   3781 C  CZ  . ARG A 1 510 ? -18.126 -64.170 -26.058 1.00 26.61  ? 773  ARG A CZ  1 
ATOM   3782 N  NH1 . ARG A 1 510 ? -18.928 -65.094 -26.553 1.00 27.86  ? 773  ARG A NH1 1 
ATOM   3783 N  NH2 . ARG A 1 510 ? -17.240 -63.570 -26.849 1.00 26.07  ? 773  ARG A NH2 1 
ATOM   3784 N  N   . LEU A 1 511 ? -18.565 -64.099 -18.751 1.00 25.35  ? 774  LEU A N   1 
ATOM   3785 C  CA  . LEU A 1 511 ? -19.078 -65.096 -17.800 1.00 24.95  ? 774  LEU A CA  1 
ATOM   3786 C  C   . LEU A 1 511 ? -19.762 -64.342 -16.679 1.00 23.07  ? 774  LEU A C   1 
ATOM   3787 O  O   . LEU A 1 511 ? -20.902 -64.666 -16.373 1.00 22.54  ? 774  LEU A O   1 
ATOM   3788 C  CB  . LEU A 1 511 ? -17.929 -65.978 -17.301 1.00 26.91  ? 774  LEU A CB  1 
ATOM   3789 C  CG  . LEU A 1 511 ? -18.334 -67.276 -16.596 1.00 27.66  ? 774  LEU A CG  1 
ATOM   3790 C  CD1 . LEU A 1 511 ? -17.183 -68.258 -16.593 1.00 31.63  ? 774  LEU A CD1 1 
ATOM   3791 C  CD2 . LEU A 1 511 ? -18.775 -67.052 -15.161 1.00 29.08  ? 774  LEU A CD2 1 
ATOM   3792 N  N   . ALA A 1 512 ? -19.128 -63.341 -16.104 1.00 24.63  ? 775  ALA A N   1 
ATOM   3793 C  CA  . ALA A 1 512 ? -19.735 -62.612 -14.958 1.00 22.45  ? 775  ALA A CA  1 
ATOM   3794 C  C   . ALA A 1 512 ? -20.983 -61.843 -15.421 1.00 25.03  ? 775  ALA A C   1 
ATOM   3795 O  O   . ALA A 1 512 ? -21.949 -61.778 -14.671 1.00 27.12  ? 775  ALA A O   1 
ATOM   3796 C  CB  . ALA A 1 512 ? -18.718 -61.696 -14.328 1.00 20.10  ? 775  ALA A CB  1 
ATOM   3797 N  N   . ALA A 1 513 ? -20.960 -61.252 -16.616 1.00 24.66  ? 776  ALA A N   1 
ATOM   3798 C  CA  . ALA A 1 513 ? -22.116 -60.545 -17.202 1.00 24.30  ? 776  ALA A CA  1 
ATOM   3799 C  C   . ALA A 1 513 ? -23.292 -61.514 -17.272 1.00 26.04  ? 776  ALA A C   1 
ATOM   3800 O  O   . ALA A 1 513 ? -24.424 -61.129 -16.841 1.00 22.78  ? 776  ALA A O   1 
ATOM   3801 C  CB  . ALA A 1 513 ? -21.785 -59.971 -18.578 1.00 22.88  ? 776  ALA A CB  1 
ATOM   3802 N  N   . ASN A 1 514 ? -23.043 -62.696 -17.843 1.00 25.43  ? 777  ASN A N   1 
ATOM   3803 C  CA  . ASN A 1 514 ? -24.088 -63.750 -17.958 1.00 27.77  ? 777  ASN A CA  1 
ATOM   3804 C  C   . ASN A 1 514 ? -24.581 -64.119 -16.559 1.00 26.74  ? 777  ASN A C   1 
ATOM   3805 O  O   . ASN A 1 514 ? -25.802 -64.268 -16.384 1.00 27.22  ? 777  ASN A O   1 
ATOM   3806 C  CB  . ASN A 1 514 ? -23.594 -64.969 -18.720 1.00 25.92  ? 777  ASN A CB  1 
ATOM   3807 C  CG  . ASN A 1 514 ? -23.514 -64.703 -20.217 1.00 30.17  ? 777  ASN A CG  1 
ATOM   3808 O  OD1 . ASN A 1 514 ? -24.358 -64.038 -20.799 1.00 27.94  ? 777  ASN A OD1 1 
ATOM   3809 N  ND2 . ASN A 1 514 ? -22.526 -65.272 -20.881 1.00 32.16  ? 777  ASN A ND2 1 
ATOM   3810 N  N   . ALA A 1 515 ? -23.683 -64.314 -15.607 1.00 23.93  ? 778  ALA A N   1 
ATOM   3811 C  CA  . ALA A 1 515 ? -24.059 -64.668 -14.216 1.00 23.07  ? 778  ALA A CA  1 
ATOM   3812 C  C   . ALA A 1 515 ? -24.941 -63.562 -13.602 1.00 23.32  ? 778  ALA A C   1 
ATOM   3813 O  O   . ALA A 1 515 ? -25.959 -63.872 -13.014 1.00 24.26  ? 778  ALA A O   1 
ATOM   3814 C  CB  . ALA A 1 515 ? -22.836 -64.944 -13.383 1.00 20.97  ? 778  ALA A CB  1 
ATOM   3815 N  N   . ILE A 1 516 ? -24.604 -62.285 -13.753 1.00 27.43  ? 779  ILE A N   1 
ATOM   3816 C  CA  . ILE A 1 516 ? -25.400 -61.181 -13.127 1.00 27.30  ? 779  ILE A CA  1 
ATOM   3817 C  C   . ILE A 1 516 ? -26.768 -61.115 -13.848 1.00 29.55  ? 779  ILE A C   1 
ATOM   3818 O  O   . ILE A 1 516 ? -27.760 -60.985 -13.147 1.00 27.16  ? 779  ILE A O   1 
ATOM   3819 C  CB  . ILE A 1 516 ? -24.658 -59.824 -13.168 1.00 25.68  ? 779  ILE A CB  1 
ATOM   3820 C  CG1 . ILE A 1 516 ? -23.424 -59.822 -12.281 1.00 25.13  ? 779  ILE A CG1 1 
ATOM   3821 C  CG2 . ILE A 1 516 ? -25.570 -58.645 -12.833 1.00 23.87  ? 779  ILE A CG2 1 
ATOM   3822 C  CD1 . ILE A 1 516 ? -22.390 -58.830 -12.741 1.00 24.78  ? 779  ILE A CD1 1 
ATOM   3823 N  N   . CYS A 1 517 ? -26.833 -61.184 -15.185 1.00 25.94  ? 780  CYS A N   1 
ATOM   3824 C  CA  . CYS A 1 517 ? -28.123 -61.146 -15.920 1.00 27.66  ? 780  CYS A CA  1 
ATOM   3825 C  C   . CYS A 1 517 ? -28.971 -62.381 -15.588 1.00 29.32  ? 780  CYS A C   1 
ATOM   3826 O  O   . CYS A 1 517 ? -30.195 -62.306 -15.738 1.00 27.41  ? 780  CYS A O   1 
ATOM   3827 C  CB  . CYS A 1 517 ? -27.910 -61.012 -17.418 1.00 26.71  ? 780  CYS A CB  1 
ATOM   3828 S  SG  . CYS A 1 517 ? -27.213 -59.398 -17.824 1.00 29.19  ? 780  CYS A SG  1 
ATOM   3829 N  N   . SER A 1 518 ? -28.352 -63.454 -15.111 1.00 28.31  ? 781  SER A N   1 
ATOM   3830 C  CA  . SER A 1 518 ? -29.059 -64.683 -14.688 1.00 26.15  ? 781  SER A CA  1 
ATOM   3831 C  C   . SER A 1 518 ? -29.607 -64.490 -13.277 1.00 28.19  ? 781  SER A C   1 
ATOM   3832 O  O   . SER A 1 518 ? -30.675 -65.064 -12.984 1.00 28.03  ? 781  SER A O   1 
ATOM   3833 C  CB  . SER A 1 518 ? -28.205 -65.920 -14.789 1.00 27.45  ? 781  SER A CB  1 
ATOM   3834 O  OG  . SER A 1 518 ? -27.930 -66.263 -16.135 1.00 31.01  ? 781  SER A OG  1 
ATOM   3835 N  N   . ALA A 1 519 ? -28.975 -63.631 -12.474 1.00 29.15  ? 782  ALA A N   1 
ATOM   3836 C  CA  . ALA A 1 519 ? -29.254 -63.490 -11.016 1.00 31.02  ? 782  ALA A CA  1 
ATOM   3837 C  C   . ALA A 1 519 ? -30.263 -62.382 -10.730 1.00 27.29  ? 782  ALA A C   1 
ATOM   3838 O  O   . ALA A 1 519 ? -30.800 -62.369 -9.614  1.00 28.44  ? 782  ALA A O   1 
ATOM   3839 C  CB  . ALA A 1 519 ? -27.974 -63.273 -10.231 1.00 29.85  ? 782  ALA A CB  1 
ATOM   3840 N  N   . VAL A 1 520 ? -30.406 -61.448 -11.649 1.00 27.15  ? 783  VAL A N   1 
ATOM   3841 C  CA  . VAL A 1 520 ? -31.354 -60.314 -11.602 1.00 27.01  ? 783  VAL A CA  1 
ATOM   3842 C  C   . VAL A 1 520 ? -32.579 -60.699 -12.438 1.00 30.08  ? 783  VAL A C   1 
ATOM   3843 O  O   . VAL A 1 520 ? -32.453 -61.253 -13.533 1.00 26.62  ? 783  VAL A O   1 
ATOM   3844 C  CB  . VAL A 1 520 ? -30.692 -59.025 -12.128 1.00 28.71  ? 783  VAL A CB  1 
ATOM   3845 C  CG1 . VAL A 1 520 ? -31.684 -57.859 -12.156 1.00 26.41  ? 783  VAL A CG1 1 
ATOM   3846 C  CG2 . VAL A 1 520 ? -29.435 -58.642 -11.328 1.00 27.94  ? 783  VAL A CG2 1 
ATOM   3847 N  N   . PRO A 1 521 ? -33.804 -60.422 -11.935 1.00 27.72  ? 784  PRO A N   1 
ATOM   3848 C  CA  . PRO A 1 521 ? -35.018 -60.767 -12.670 1.00 27.02  ? 784  PRO A CA  1 
ATOM   3849 C  C   . PRO A 1 521 ? -34.977 -60.275 -14.119 1.00 30.00  ? 784  PRO A C   1 
ATOM   3850 O  O   . PRO A 1 521 ? -34.601 -59.149 -14.377 1.00 30.60  ? 784  PRO A O   1 
ATOM   3851 C  CB  . PRO A 1 521 ? -36.122 -60.176 -11.789 1.00 27.38  ? 784  PRO A CB  1 
ATOM   3852 C  CG  . PRO A 1 521 ? -35.559 -60.370 -10.351 1.00 28.31  ? 784  PRO A CG  1 
ATOM   3853 C  CD  . PRO A 1 521 ? -34.082 -60.009 -10.539 1.00 26.98  ? 784  PRO A CD  1 
ATOM   3854 N  N   A SER A 1 522 ? -35.374 -61.160 -15.035 0.25 29.72  ? 785  SER A N   1 
ATOM   3855 N  N   B SER A 1 522 ? -35.395 -61.150 -15.036 0.25 29.69  ? 785  SER A N   1 
ATOM   3856 C  CA  A SER A 1 522 ? -35.280 -61.006 -16.509 0.25 32.51  ? 785  SER A CA  1 
ATOM   3857 C  CA  B SER A 1 522 ? -35.264 -61.001 -16.508 0.25 32.50  ? 785  SER A CA  1 
ATOM   3858 C  C   A SER A 1 522 ? -35.838 -59.655 -16.954 0.25 32.35  ? 785  SER A C   1 
ATOM   3859 C  C   B SER A 1 522 ? -35.849 -59.666 -16.972 0.25 32.33  ? 785  SER A C   1 
ATOM   3860 O  O   A SER A 1 522 ? -35.190 -59.006 -17.797 0.25 32.65  ? 785  SER A O   1 
ATOM   3861 O  O   B SER A 1 522 ? -35.225 -59.034 -17.846 0.25 32.64  ? 785  SER A O   1 
ATOM   3862 C  CB  A SER A 1 522 ? -36.008 -62.136 -17.192 0.25 34.47  ? 785  SER A CB  1 
ATOM   3863 C  CB  B SER A 1 522 ? -35.922 -62.162 -17.219 0.25 34.51  ? 785  SER A CB  1 
ATOM   3864 O  OG  A SER A 1 522 ? -37.362 -62.179 -16.767 0.25 34.28  ? 785  SER A OG  1 
ATOM   3865 O  OG  B SER A 1 522 ? -35.736 -63.370 -16.495 0.25 34.57  ? 785  SER A OG  1 
ATOM   3866 N  N   . HIS A 1 523 ? -36.994 -59.252 -16.412 1.00 32.69  ? 786  HIS A N   1 
ATOM   3867 C  CA  . HIS A 1 523 ? -37.720 -58.022 -16.850 1.00 31.43  ? 786  HIS A CA  1 
ATOM   3868 C  C   . HIS A 1 523 ? -37.332 -56.755 -16.088 1.00 33.39  ? 786  HIS A C   1 
ATOM   3869 O  O   . HIS A 1 523 ? -37.739 -55.677 -16.591 1.00 31.17  ? 786  HIS A O   1 
ATOM   3870 C  CB  . HIS A 1 523 ? -39.242 -58.251 -16.826 1.00 35.89  ? 786  HIS A CB  1 
ATOM   3871 C  CG  . HIS A 1 523 ? -39.666 -59.329 -17.753 1.00 35.05  ? 786  HIS A CG  1 
ATOM   3872 N  ND1 . HIS A 1 523 ? -39.712 -59.138 -19.115 1.00 35.86  ? 786  HIS A ND1 1 
ATOM   3873 C  CD2 . HIS A 1 523 ? -39.987 -60.623 -17.530 1.00 43.08  ? 786  HIS A CD2 1 
ATOM   3874 C  CE1 . HIS A 1 523 ? -40.075 -60.255 -19.701 1.00 34.99  ? 786  HIS A CE1 1 
ATOM   3875 N  NE2 . HIS A 1 523 ? -40.243 -61.193 -18.752 1.00 35.93  ? 786  HIS A NE2 1 
ATOM   3876 N  N   . TRP A 1 524 ? -36.582 -56.818 -14.971 1.00 29.85  ? 787  TRP A N   1 
ATOM   3877 C  CA  . TRP A 1 524 ? -36.145 -55.583 -14.252 1.00 29.16  ? 787  TRP A CA  1 
ATOM   3878 C  C   . TRP A 1 524 ? -35.256 -54.699 -15.143 1.00 33.60  ? 787  TRP A C   1 
ATOM   3879 O  O   . TRP A 1 524 ? -34.407 -55.221 -15.909 1.00 34.38  ? 787  TRP A O   1 
ATOM   3880 C  CB  . TRP A 1 524 ? -35.486 -55.948 -12.927 1.00 28.92  ? 787  TRP A CB  1 
ATOM   3881 C  CG  . TRP A 1 524 ? -36.477 -56.399 -11.892 1.00 30.12  ? 787  TRP A CG  1 
ATOM   3882 C  CD1 . TRP A 1 524 ? -37.804 -56.683 -12.075 1.00 30.73  ? 787  TRP A CD1 1 
ATOM   3883 C  CD2 . TRP A 1 524 ? -36.210 -56.671 -10.508 1.00 28.71  ? 787  TRP A CD2 1 
ATOM   3884 N  NE1 . TRP A 1 524 ? -38.367 -57.133 -10.913 1.00 29.93  ? 787  TRP A NE1 1 
ATOM   3885 C  CE2 . TRP A 1 524 ? -37.417 -57.104 -9.923  1.00 27.90  ? 787  TRP A CE2 1 
ATOM   3886 C  CE3 . TRP A 1 524 ? -35.067 -56.592 -9.713  1.00 28.85  ? 787  TRP A CE3 1 
ATOM   3887 C  CZ2 . TRP A 1 524 ? -37.504 -57.447 -8.573  1.00 31.15  ? 787  TRP A CZ2 1 
ATOM   3888 C  CZ3 . TRP A 1 524 ? -35.159 -56.950 -8.384  1.00 30.68  ? 787  TRP A CZ3 1 
ATOM   3889 C  CH2 . TRP A 1 524 ? -36.356 -57.363 -7.819  1.00 26.93  ? 787  TRP A CH2 1 
ATOM   3890 N  N   . VAL A 1 525 ? -35.488 -53.394 -15.102 1.00 33.33  ? 788  VAL A N   1 
ATOM   3891 C  CA  . VAL A 1 525 ? -34.890 -52.431 -16.071 1.00 35.30  ? 788  VAL A CA  1 
ATOM   3892 C  C   . VAL A 1 525 ? -33.536 -51.949 -15.524 1.00 33.98  ? 788  VAL A C   1 
ATOM   3893 O  O   . VAL A 1 525 ? -33.424 -51.436 -14.401 1.00 30.59  ? 788  VAL A O   1 
ATOM   3894 C  CB  . VAL A 1 525 ? -35.853 -51.247 -16.353 1.00 35.69  ? 788  VAL A CB  1 
ATOM   3895 C  CG1 . VAL A 1 525 ? -35.238 -50.226 -17.313 1.00 38.89  ? 788  VAL A CG1 1 
ATOM   3896 C  CG2 . VAL A 1 525 ? -37.211 -51.690 -16.881 1.00 36.49  ? 788  VAL A CG2 1 
ATOM   3897 N  N   . PRO A 1 526 ? -32.462 -52.021 -16.327 1.00 34.72  ? 789  PRO A N   1 
ATOM   3898 C  CA  . PRO A 1 526 ? -31.182 -51.411 -15.944 1.00 34.01  ? 789  PRO A CA  1 
ATOM   3899 C  C   . PRO A 1 526 ? -31.281 -49.905 -15.625 1.00 36.86  ? 789  PRO A C   1 
ATOM   3900 O  O   . PRO A 1 526 ? -31.956 -49.212 -16.365 1.00 38.96  ? 789  PRO A O   1 
ATOM   3901 C  CB  . PRO A 1 526 ? -30.301 -51.566 -17.183 1.00 33.31  ? 789  PRO A CB  1 
ATOM   3902 C  CG  . PRO A 1 526 ? -30.996 -52.567 -18.098 1.00 34.82  ? 789  PRO A CG  1 
ATOM   3903 C  CD  . PRO A 1 526 ? -32.441 -52.653 -17.654 1.00 37.07  ? 789  PRO A CD  1 
ATOM   3904 N  N   . THR A 1 527 ? -30.642 -49.451 -14.541 1.00 39.15  ? 790  THR A N   1 
ATOM   3905 C  CA  . THR A 1 527 ? -30.605 -48.042 -14.075 1.00 47.89  ? 790  THR A CA  1 
ATOM   3906 C  C   . THR A 1 527 ? -29.190 -47.569 -13.816 1.00 47.59  ? 790  THR A C   1 
ATOM   3907 O  O   . THR A 1 527 ? -28.301 -48.418 -13.662 1.00 50.73  ? 790  THR A O   1 
ATOM   3908 C  CB  . THR A 1 527 ? -31.264 -47.781 -12.712 1.00 55.32  ? 790  THR A CB  1 
ATOM   3909 O  OG1 . THR A 1 527 ? -30.652 -48.552 -11.666 1.00 62.36  ? 790  THR A OG1 1 
ATOM   3910 C  CG2 . THR A 1 527 ? -32.749 -48.025 -12.767 1.00 60.16  ? 790  THR A CG2 1 
ATOM   3911 N  N   . SER A 1 528 ? -29.050 -46.251 -13.698 1.00 59.15  ? 791  SER A N   1 
ATOM   3912 C  CA  . SER A 1 528 ? -27.807 -45.501 -13.377 1.00 69.40  ? 791  SER A CA  1 
ATOM   3913 C  C   . SER A 1 528 ? -28.196 -44.092 -12.935 1.00 87.11  ? 791  SER A C   1 
ATOM   3914 O  O   . SER A 1 528 ? -28.979 -43.458 -13.681 1.00 95.72  ? 791  SER A O   1 
ATOM   3915 C  CB  . SER A 1 528 ? -26.905 -45.436 -14.569 1.00 63.95  ? 791  SER A CB  1 
ATOM   3916 O  OG  . SER A 1 528 ? -25.582 -45.154 -14.159 1.00 72.70  ? 791  SER A OG  1 
ATOM   3917 N  N   . ARG A 1 529 ? -27.645 -43.603 -11.816 1.00 104.00 ? 792  ARG A N   1 
ATOM   3918 C  CA  . ARG A 1 529 ? -27.968 -42.253 -11.261 1.00 105.65 ? 792  ARG A CA  1 
ATOM   3919 C  C   . ARG A 1 529 ? -27.147 -41.144 -11.954 1.00 108.98 ? 792  ARG A C   1 
ATOM   3920 O  O   . ARG A 1 529 ? -27.616 -39.986 -11.964 1.00 114.05 ? 792  ARG A O   1 
ATOM   3921 C  CB  . ARG A 1 529 ? -27.836 -42.251 -9.734  1.00 97.69  ? 792  ARG A CB  1 
ATOM   3922 C  CG  . ARG A 1 529 ? -29.081 -42.771 -9.029  1.00 96.90  ? 792  ARG A CG  1 
ATOM   3923 C  CD  . ARG A 1 529 ? -29.059 -42.522 -7.535  1.00 98.97  ? 792  ARG A CD  1 
ATOM   3924 N  NE  . ARG A 1 529 ? -29.622 -43.624 -6.761  1.00 94.92  ? 792  ARG A NE  1 
ATOM   3925 C  CZ  . ARG A 1 529 ? -29.618 -43.702 -5.433  1.00 84.17  ? 792  ARG A CZ  1 
ATOM   3926 N  NH1 . ARG A 1 529 ? -29.092 -42.723 -4.712  1.00 79.08  ? 792  ARG A NH1 1 
ATOM   3927 N  NH2 . ARG A 1 529 ? -30.143 -44.759 -4.832  1.00 75.11  ? 792  ARG A NH2 1 
ATOM   3928 N  N   . ALA A 1 536 ? -20.270 -40.357 -25.501 1.00 120.25 ? 799  ALA A N   1 
ATOM   3929 C  CA  . ALA A 1 536 ? -20.533 -41.794 -25.772 1.00 118.67 ? 799  ALA A CA  1 
ATOM   3930 C  C   . ALA A 1 536 ? -22.047 -42.094 -25.804 1.00 107.11 ? 799  ALA A C   1 
ATOM   3931 O  O   . ALA A 1 536 ? -22.865 -41.207 -25.458 1.00 111.32 ? 799  ALA A O   1 
ATOM   3932 C  CB  . ALA A 1 536 ? -19.817 -42.650 -24.749 1.00 124.10 ? 799  ALA A CB  1 
ATOM   3933 N  N   . THR A 1 537 ? -22.408 -43.313 -26.220 1.00 84.10  ? 800  THR A N   1 
ATOM   3934 C  CA  . THR A 1 537 ? -23.803 -43.768 -26.453 1.00 69.27  ? 800  THR A CA  1 
ATOM   3935 C  C   . THR A 1 537 ? -24.014 -45.068 -25.662 1.00 64.57  ? 800  THR A C   1 
ATOM   3936 O  O   . THR A 1 537 ? -23.194 -46.032 -25.829 1.00 68.40  ? 800  THR A O   1 
ATOM   3937 C  CB  . THR A 1 537 ? -24.074 -43.881 -27.960 1.00 77.51  ? 800  THR A CB  1 
ATOM   3938 O  OG1 . THR A 1 537 ? -23.553 -45.110 -28.473 1.00 82.38  ? 800  THR A OG1 1 
ATOM   3939 C  CG2 . THR A 1 537 ? -23.488 -42.733 -28.753 1.00 74.10  ? 800  THR A CG2 1 
ATOM   3940 N  N   A HIS A 1 538 ? -25.070 -45.119 -24.838 0.15 57.07  ? 801  HIS A N   1 
ATOM   3941 N  N   B HIS A 1 538 ? -25.094 -45.112 -24.867 0.15 58.96  ? 801  HIS A N   1 
ATOM   3942 C  CA  A HIS A 1 538 ? -25.320 -46.195 -23.839 0.15 49.69  ? 801  HIS A CA  1 
ATOM   3943 C  CA  B HIS A 1 538 ? -25.377 -46.158 -23.844 0.15 52.44  ? 801  HIS A CA  1 
ATOM   3944 C  C   A HIS A 1 538 ? -26.355 -47.196 -24.374 0.15 43.89  ? 801  HIS A C   1 
ATOM   3945 C  C   B HIS A 1 538 ? -26.379 -47.188 -24.387 0.15 45.33  ? 801  HIS A C   1 
ATOM   3946 O  O   A HIS A 1 538 ? -27.460 -47.282 -23.796 0.15 40.41  ? 801  HIS A O   1 
ATOM   3947 O  O   B HIS A 1 538 ? -27.492 -47.288 -23.826 0.15 41.58  ? 801  HIS A O   1 
ATOM   3948 C  CB  A HIS A 1 538 ? -25.725 -45.576 -22.495 0.15 49.44  ? 801  HIS A CB  1 
ATOM   3949 C  CB  B HIS A 1 538 ? -25.843 -45.508 -22.528 0.15 54.39  ? 801  HIS A CB  1 
ATOM   3950 C  CG  A HIS A 1 538 ? -24.620 -44.842 -21.811 0.15 47.86  ? 801  HIS A CG  1 
ATOM   3951 C  CG  B HIS A 1 538 ? -26.517 -44.184 -22.682 0.15 55.31  ? 801  HIS A CG  1 
ATOM   3952 N  ND1 A HIS A 1 538 ? -24.375 -44.970 -20.457 0.15 46.90  ? 801  HIS A ND1 1 
ATOM   3953 N  ND1 B HIS A 1 538 ? -26.162 -43.082 -21.922 0.15 54.36  ? 801  HIS A ND1 1 
ATOM   3954 C  CD2 A HIS A 1 538 ? -23.697 -43.974 -22.282 0.15 47.38  ? 801  HIS A CD2 1 
ATOM   3955 C  CD2 B HIS A 1 538 ? -27.515 -43.774 -23.498 0.15 56.19  ? 801  HIS A CD2 1 
ATOM   3956 C  CE1 A HIS A 1 538 ? -23.353 -44.210 -20.123 0.15 45.73  ? 801  HIS A CE1 1 
ATOM   3957 C  CE1 B HIS A 1 538 ? -26.914 -42.056 -22.262 0.15 54.44  ? 801  HIS A CE1 1 
ATOM   3958 N  NE2 A HIS A 1 538 ? -22.916 -43.593 -21.224 0.15 45.53  ? 801  HIS A NE2 1 
ATOM   3959 N  NE2 B HIS A 1 538 ? -27.754 -42.454 -23.228 0.15 54.24  ? 801  HIS A NE2 1 
ATOM   3960 N  N   . GLU A 1 539 ? -25.978 -47.965 -25.402 1.00 41.34  ? 802  GLU A N   1 
ATOM   3961 C  CA  . GLU A 1 539 ? -26.867 -48.976 -26.035 1.00 40.52  ? 802  GLU A CA  1 
ATOM   3962 C  C   . GLU A 1 539 ? -27.215 -50.138 -25.091 1.00 40.42  ? 802  GLU A C   1 
ATOM   3963 O  O   . GLU A 1 539 ? -28.194 -50.850 -25.399 1.00 37.29  ? 802  GLU A O   1 
ATOM   3964 C  CB  . GLU A 1 539 ? -26.281 -49.552 -27.317 1.00 49.03  ? 802  GLU A CB  1 
ATOM   3965 C  CG  . GLU A 1 539 ? -26.719 -48.808 -28.565 1.00 49.40  ? 802  GLU A CG  1 
ATOM   3966 C  CD  . GLU A 1 539 ? -25.707 -47.760 -28.917 1.00 56.51  ? 802  GLU A CD  1 
ATOM   3967 O  OE1 . GLU A 1 539 ? -25.899 -47.101 -29.965 1.00 70.96  ? 802  GLU A OE1 1 
ATOM   3968 O  OE2 . GLU A 1 539 ? -24.720 -47.632 -28.140 1.00 57.79  ? 802  GLU A OE2 1 
ATOM   3969 N  N   . TRP A 1 540 ? -26.471 -50.335 -23.995 1.00 31.57  ? 803  TRP A N   1 
ATOM   3970 C  CA  . TRP A 1 540 ? -26.764 -51.412 -23.027 1.00 33.88  ? 803  TRP A CA  1 
ATOM   3971 C  C   . TRP A 1 540 ? -27.918 -51.025 -22.101 1.00 34.16  ? 803  TRP A C   1 
ATOM   3972 O  O   . TRP A 1 540 ? -28.309 -51.868 -21.284 1.00 31.63  ? 803  TRP A O   1 
ATOM   3973 C  CB  . TRP A 1 540 ? -25.483 -51.747 -22.237 1.00 33.67  ? 803  TRP A CB  1 
ATOM   3974 C  CG  . TRP A 1 540 ? -24.860 -50.609 -21.489 1.00 28.67  ? 803  TRP A CG  1 
ATOM   3975 C  CD1 . TRP A 1 540 ? -25.154 -50.218 -20.218 1.00 29.08  ? 803  TRP A CD1 1 
ATOM   3976 C  CD2 . TRP A 1 540 ? -23.828 -49.712 -21.943 1.00 29.71  ? 803  TRP A CD2 1 
ATOM   3977 N  NE1 . TRP A 1 540 ? -24.392 -49.130 -19.857 1.00 30.09  ? 803  TRP A NE1 1 
ATOM   3978 C  CE2 . TRP A 1 540 ? -23.573 -48.796 -20.892 1.00 29.10  ? 803  TRP A CE2 1 
ATOM   3979 C  CE3 . TRP A 1 540 ? -23.124 -49.554 -23.137 1.00 31.55  ? 803  TRP A CE3 1 
ATOM   3980 C  CZ2 . TRP A 1 540 ? -22.597 -47.810 -20.982 1.00 32.91  ? 803  TRP A CZ2 1 
ATOM   3981 C  CZ3 . TRP A 1 540 ? -22.179 -48.565 -23.239 1.00 35.41  ? 803  TRP A CZ3 1 
ATOM   3982 C  CH2 . TRP A 1 540 ? -21.899 -47.717 -22.166 1.00 33.80  ? 803  TRP A CH2 1 
ATOM   3983 N  N   . MET A 1 541 ? -28.371 -49.770 -22.107 1.00 37.76  ? 804  MET A N   1 
ATOM   3984 C  CA  . MET A 1 541 ? -29.439 -49.314 -21.177 1.00 37.66  ? 804  MET A CA  1 
ATOM   3985 C  C   . MET A 1 541 ? -30.786 -49.629 -21.850 1.00 40.20  ? 804  MET A C   1 
ATOM   3986 O  O   . MET A 1 541 ? -31.326 -48.748 -22.508 1.00 38.29  ? 804  MET A O   1 
ATOM   3987 C  CB  . MET A 1 541 ? -29.337 -47.819 -20.838 1.00 37.98  ? 804  MET A CB  1 
ATOM   3988 C  CG  . MET A 1 541 ? -28.079 -47.463 -20.074 1.00 40.72  ? 804  MET A CG  1 
ATOM   3989 S  SD  . MET A 1 541 ? -27.910 -48.414 -18.558 1.00 44.81  ? 804  MET A SD  1 
ATOM   3990 C  CE  . MET A 1 541 ? -29.177 -47.645 -17.557 1.00 46.28  ? 804  MET A CE  1 
ATOM   3991 N  N   . THR A 1 542 ? -31.256 -50.871 -21.712 1.00 37.80  ? 805  THR A N   1 
ATOM   3992 C  CA  . THR A 1 542 ? -32.359 -51.475 -22.510 1.00 38.29  ? 805  THR A CA  1 
ATOM   3993 C  C   . THR A 1 542 ? -32.745 -52.820 -21.897 1.00 38.09  ? 805  THR A C   1 
ATOM   3994 O  O   . THR A 1 542 ? -31.891 -53.442 -21.214 1.00 36.32  ? 805  THR A O   1 
ATOM   3995 C  CB  . THR A 1 542 ? -31.974 -51.708 -23.977 1.00 43.00  ? 805  THR A CB  1 
ATOM   3996 O  OG1 . THR A 1 542 ? -33.066 -52.285 -24.704 1.00 42.38  ? 805  THR A OG1 1 
ATOM   3997 C  CG2 . THR A 1 542 ? -30.796 -52.654 -24.108 1.00 42.97  ? 805  THR A CG2 1 
ATOM   3998 N  N   . THR A 1 543 ? -33.979 -53.264 -22.152 1.00 34.22  ? 806  THR A N   1 
ATOM   3999 C  CA  . THR A 1 543 ? -34.518 -54.586 -21.728 1.00 37.96  ? 806  THR A CA  1 
ATOM   4000 C  C   . THR A 1 543 ? -34.580 -55.522 -22.934 1.00 34.02  ? 806  THR A C   1 
ATOM   4001 O  O   . THR A 1 543 ? -34.943 -56.671 -22.738 1.00 33.47  ? 806  THR A O   1 
ATOM   4002 C  CB  . THR A 1 543 ? -35.908 -54.457 -21.076 1.00 44.11  ? 806  THR A CB  1 
ATOM   4003 O  OG1 . THR A 1 543 ? -36.768 -53.694 -21.932 1.00 39.69  ? 806  THR A OG1 1 
ATOM   4004 C  CG2 . THR A 1 543 ? -35.816 -53.781 -19.727 1.00 45.98  ? 806  THR A CG2 1 
ATOM   4005 N  N   . GLU A 1 544 ? -34.227 -55.037 -24.120 1.00 34.28  ? 807  GLU A N   1 
ATOM   4006 C  CA  . GLU A 1 544 ? -34.068 -55.863 -25.350 1.00 33.80  ? 807  GLU A CA  1 
ATOM   4007 C  C   . GLU A 1 544 ? -32.964 -56.896 -25.137 1.00 35.71  ? 807  GLU A C   1 
ATOM   4008 O  O   . GLU A 1 544 ? -32.081 -56.696 -24.251 1.00 34.38  ? 807  GLU A O   1 
ATOM   4009 C  CB  . GLU A 1 544 ? -33.740 -54.943 -26.513 1.00 39.14  ? 807  GLU A CB  1 
ATOM   4010 C  CG  . GLU A 1 544 ? -33.648 -55.658 -27.832 1.00 47.29  ? 807  GLU A CG  1 
ATOM   4011 C  CD  . GLU A 1 544 ? -33.681 -54.690 -29.017 1.00 58.95  ? 807  GLU A CD  1 
ATOM   4012 O  OE1 . GLU A 1 544 ? -34.161 -55.106 -30.114 1.00 56.49  ? 807  GLU A OE1 1 
ATOM   4013 O  OE2 . GLU A 1 544 ? -33.241 -53.512 -28.848 1.00 46.96  ? 807  GLU A OE2 1 
ATOM   4014 N  N   . ASP A 1 545 ? -33.038 -57.986 -25.885 1.00 33.40  ? 808  ASP A N   1 
ATOM   4015 C  CA  . ASP A 1 545 ? -32.143 -59.159 -25.825 1.00 35.16  ? 808  ASP A CA  1 
ATOM   4016 C  C   . ASP A 1 545 ? -30.732 -58.655 -26.156 1.00 33.83  ? 808  ASP A C   1 
ATOM   4017 O  O   . ASP A 1 545 ? -30.625 -57.920 -27.163 1.00 29.18  ? 808  ASP A O   1 
ATOM   4018 C  CB  . ASP A 1 545 ? -32.637 -60.194 -26.839 1.00 42.19  ? 808  ASP A CB  1 
ATOM   4019 C  CG  . ASP A 1 545 ? -31.822 -61.474 -26.920 1.00 52.65  ? 808  ASP A CG  1 
ATOM   4020 O  OD1 . ASP A 1 545 ? -30.592 -61.383 -26.988 1.00 67.55  ? 808  ASP A OD1 1 
ATOM   4021 O  OD2 . ASP A 1 545 ? -32.433 -62.563 -26.916 1.00 74.70  ? 808  ASP A OD2 1 
ATOM   4022 N  N   . MET A 1 546 ? -29.687 -59.046 -25.403 1.00 28.75  ? 809  MET A N   1 
ATOM   4023 C  CA  . MET A 1 546 ? -28.328 -58.452 -25.649 1.00 29.19  ? 809  MET A CA  1 
ATOM   4024 C  C   . MET A 1 546 ? -27.738 -58.976 -26.959 1.00 28.14  ? 809  MET A C   1 
ATOM   4025 O  O   . MET A 1 546 ? -27.006 -58.192 -27.582 1.00 27.25  ? 809  MET A O   1 
ATOM   4026 C  CB  . MET A 1 546 ? -27.362 -58.643 -24.476 1.00 33.03  ? 809  MET A CB  1 
ATOM   4027 C  CG  . MET A 1 546 ? -27.701 -57.710 -23.275 1.00 33.83  ? 809  MET A CG  1 
ATOM   4028 S  SD  . MET A 1 546 ? -27.577 -55.930 -23.655 1.00 41.91  ? 809  MET A SD  1 
ATOM   4029 C  CE  . MET A 1 546 ? -29.183 -55.538 -24.307 1.00 52.53  ? 809  MET A CE  1 
ATOM   4030 N  N   . LEU A 1 547 ? -28.106 -60.170 -27.443 1.00 26.15  ? 810  LEU A N   1 
ATOM   4031 C  CA  . LEU A 1 547 ? -27.570 -60.605 -28.762 1.00 28.40  ? 810  LEU A CA  1 
ATOM   4032 C  C   . LEU A 1 547 ? -28.143 -59.719 -29.865 1.00 31.36  ? 810  LEU A C   1 
ATOM   4033 O  O   . LEU A 1 547 ? -27.368 -59.467 -30.808 1.00 31.61  ? 810  LEU A O   1 
ATOM   4034 C  CB  . LEU A 1 547 ? -27.837 -62.071 -29.064 1.00 31.68  ? 810  LEU A CB  1 
ATOM   4035 C  CG  . LEU A 1 547 ? -27.197 -62.584 -30.356 1.00 34.62  ? 810  LEU A CG  1 
ATOM   4036 C  CD1 . LEU A 1 547 ? -25.675 -62.520 -30.292 1.00 33.15  ? 810  LEU A CD1 1 
ATOM   4037 C  CD2 . LEU A 1 547 ? -27.621 -64.002 -30.597 1.00 37.18  ? 810  LEU A CD2 1 
ATOM   4038 N  N   . THR A 1 548 ? -29.405 -59.255 -29.774 1.00 30.38  ? 811  THR A N   1 
ATOM   4039 C  CA  . THR A 1 548 ? -30.021 -58.406 -30.842 1.00 32.61  ? 811  THR A CA  1 
ATOM   4040 C  C   . THR A 1 548 ? -29.341 -57.030 -30.844 1.00 32.16  ? 811  THR A C   1 
ATOM   4041 O  O   . THR A 1 548 ? -29.073 -56.493 -31.921 1.00 30.30  ? 811  THR A O   1 
ATOM   4042 C  CB  . THR A 1 548 ? -31.544 -58.298 -30.669 1.00 37.23  ? 811  THR A CB  1 
ATOM   4043 O  OG1 . THR A 1 548 ? -32.043 -59.616 -30.859 1.00 39.60  ? 811  THR A OG1 1 
ATOM   4044 C  CG2 . THR A 1 548 ? -32.232 -57.347 -31.632 1.00 37.80  ? 811  THR A CG2 1 
ATOM   4045 N  N   . VAL A 1 549 ? -29.164 -56.435 -29.674 1.00 28.13  ? 812  VAL A N   1 
ATOM   4046 C  CA  . VAL A 1 549 ? -28.371 -55.194 -29.482 1.00 33.38  ? 812  VAL A CA  1 
ATOM   4047 C  C   . VAL A 1 549 ? -26.952 -55.378 -30.046 1.00 31.02  ? 812  VAL A C   1 
ATOM   4048 O  O   . VAL A 1 549 ? -26.504 -54.483 -30.766 1.00 28.34  ? 812  VAL A O   1 
ATOM   4049 C  CB  . VAL A 1 549 ? -28.324 -54.754 -28.007 1.00 34.78  ? 812  VAL A CB  1 
ATOM   4050 C  CG1 . VAL A 1 549 ? -27.513 -53.477 -27.877 1.00 36.81  ? 812  VAL A CG1 1 
ATOM   4051 C  CG2 . VAL A 1 549 ? -29.716 -54.563 -27.416 1.00 38.32  ? 812  VAL A CG2 1 
ATOM   4052 N  N   . TRP A 1 550 ? -26.245 -56.459 -29.703 1.00 33.71  ? 813  TRP A N   1 
ATOM   4053 C  CA  . TRP A 1 550 ? -24.874 -56.743 -30.240 1.00 30.38  ? 813  TRP A CA  1 
ATOM   4054 C  C   . TRP A 1 550 ? -24.910 -56.688 -31.763 1.00 32.61  ? 813  TRP A C   1 
ATOM   4055 O  O   . TRP A 1 550 ? -24.054 -56.002 -32.378 1.00 33.67  ? 813  TRP A O   1 
ATOM   4056 C  CB  . TRP A 1 550 ? -24.297 -58.069 -29.743 1.00 28.74  ? 813  TRP A CB  1 
ATOM   4057 C  CG  . TRP A 1 550 ? -22.832 -58.231 -30.003 1.00 26.73  ? 813  TRP A CG  1 
ATOM   4058 C  CD1 . TRP A 1 550 ? -21.826 -58.057 -29.088 1.00 30.90  ? 813  TRP A CD1 1 
ATOM   4059 C  CD2 . TRP A 1 550 ? -22.192 -58.615 -31.224 1.00 28.62  ? 813  TRP A CD2 1 
ATOM   4060 N  NE1 . TRP A 1 550 ? -20.606 -58.298 -29.653 1.00 31.10  ? 813  TRP A NE1 1 
ATOM   4061 C  CE2 . TRP A 1 550 ? -20.794 -58.601 -30.980 1.00 30.16  ? 813  TRP A CE2 1 
ATOM   4062 C  CE3 . TRP A 1 550 ? -22.650 -59.008 -32.483 1.00 29.21  ? 813  TRP A CE3 1 
ATOM   4063 C  CZ2 . TRP A 1 550 ? -19.851 -58.901 -31.960 1.00 27.40  ? 813  TRP A CZ2 1 
ATOM   4064 C  CZ3 . TRP A 1 550 ? -21.715 -59.296 -33.456 1.00 30.65  ? 813  TRP A CZ3 1 
ATOM   4065 C  CH2 . TRP A 1 550 ? -20.341 -59.263 -33.190 1.00 29.19  ? 813  TRP A CH2 1 
ATOM   4066 N  N   . ASN A 1 551 ? -25.857 -57.387 -32.381 1.00 32.90  ? 814  ASN A N   1 
ATOM   4067 C  CA  . ASN A 1 551 ? -25.957 -57.408 -33.863 1.00 33.26  ? 814  ASN A CA  1 
ATOM   4068 C  C   . ASN A 1 551 ? -26.176 -55.990 -34.386 1.00 29.18  ? 814  ASN A C   1 
ATOM   4069 O  O   . ASN A 1 551 ? -25.565 -55.624 -35.410 1.00 32.15  ? 814  ASN A O   1 
ATOM   4070 C  CB  . ASN A 1 551 ? -27.049 -58.357 -34.374 1.00 35.17  ? 814  ASN A CB  1 
ATOM   4071 C  CG  . ASN A 1 551 ? -26.527 -59.753 -34.621 1.00 39.27  ? 814  ASN A CG  1 
ATOM   4072 O  OD1 . ASN A 1 551 ? -25.647 -59.975 -35.462 1.00 44.92  ? 814  ASN A OD1 1 
ATOM   4073 N  ND2 . ASN A 1 551 ? -27.053 -60.718 -33.885 1.00 41.16  ? 814  ASN A ND2 1 
ATOM   4074 N  N   . ARG A 1 552 ? -27.084 -55.228 -33.793 1.00 30.49  ? 815  ARG A N   1 
ATOM   4075 C  CA  . ARG A 1 552 ? -27.366 -53.845 -34.277 1.00 34.45  ? 815  ARG A CA  1 
ATOM   4076 C  C   . ARG A 1 552 ? -26.070 -52.986 -34.252 1.00 36.76  ? 815  ARG A C   1 
ATOM   4077 O  O   . ARG A 1 552 ? -25.764 -52.265 -35.263 1.00 35.05  ? 815  ARG A O   1 
ATOM   4078 C  CB  . ARG A 1 552 ? -28.465 -53.234 -33.401 1.00 36.08  ? 815  ARG A CB  1 
ATOM   4079 C  CG  . ARG A 1 552 ? -28.985 -51.882 -33.881 1.00 38.98  ? 815  ARG A CG  1 
ATOM   4080 C  CD  . ARG A 1 552 ? -29.957 -51.247 -32.881 1.00 43.18  ? 815  ARG A CD  1 
ATOM   4081 N  NE  . ARG A 1 552 ? -31.127 -52.105 -32.889 1.00 52.07  ? 815  ARG A NE  1 
ATOM   4082 C  CZ  . ARG A 1 552 ? -31.738 -52.663 -31.844 1.00 50.61  ? 815  ARG A CZ  1 
ATOM   4083 N  NH1 . ARG A 1 552 ? -31.359 -52.444 -30.590 1.00 49.42  ? 815  ARG A NH1 1 
ATOM   4084 N  NH2 . ARG A 1 552 ? -32.767 -53.445 -32.105 1.00 54.33  ? 815  ARG A NH2 1 
ATOM   4085 N  N   . VAL A 1 553 ? -25.343 -53.028 -33.121 1.00 34.54  ? 816  VAL A N   1 
ATOM   4086 C  CA  . VAL A 1 553 ? -24.183 -52.140 -32.820 1.00 33.01  ? 816  VAL A CA  1 
ATOM   4087 C  C   . VAL A 1 553 ? -22.963 -52.577 -33.651 1.00 32.93  ? 816  VAL A C   1 
ATOM   4088 O  O   . VAL A 1 553 ? -22.347 -51.709 -34.296 1.00 36.56  ? 816  VAL A O   1 
ATOM   4089 C  CB  . VAL A 1 553 ? -23.919 -52.117 -31.307 1.00 32.93  ? 816  VAL A CB  1 
ATOM   4090 C  CG1 . VAL A 1 553 ? -22.606 -51.483 -30.977 1.00 34.49  ? 816  VAL A CG1 1 
ATOM   4091 C  CG2 . VAL A 1 553 ? -25.044 -51.397 -30.598 1.00 32.40  ? 816  VAL A CG2 1 
ATOM   4092 N  N   . TRP A 1 554 ? -22.631 -53.870 -33.671 1.00 28.90  ? 817  TRP A N   1 
ATOM   4093 C  CA  . TRP A 1 554 ? -21.341 -54.341 -34.212 1.00 26.26  ? 817  TRP A CA  1 
ATOM   4094 C  C   . TRP A 1 554 ? -21.480 -54.701 -35.678 1.00 29.33  ? 817  TRP A C   1 
ATOM   4095 O  O   . TRP A 1 554 ? -20.426 -54.818 -36.281 1.00 28.08  ? 817  TRP A O   1 
ATOM   4096 C  CB  . TRP A 1 554 ? -20.766 -55.492 -33.388 1.00 26.42  ? 817  TRP A CB  1 
ATOM   4097 C  CG  . TRP A 1 554 ? -20.293 -55.037 -32.038 1.00 28.34  ? 817  TRP A CG  1 
ATOM   4098 C  CD1 . TRP A 1 554 ? -20.911 -55.187 -30.841 1.00 24.99  ? 817  TRP A CD1 1 
ATOM   4099 C  CD2 . TRP A 1 554 ? -19.090 -54.294 -31.774 1.00 25.06  ? 817  TRP A CD2 1 
ATOM   4100 N  NE1 . TRP A 1 554 ? -20.138 -54.663 -29.840 1.00 26.04  ? 817  TRP A NE1 1 
ATOM   4101 C  CE2 . TRP A 1 554 ? -19.017 -54.106 -30.371 1.00 25.51  ? 817  TRP A CE2 1 
ATOM   4102 C  CE3 . TRP A 1 554 ? -18.026 -53.875 -32.566 1.00 23.70  ? 817  TRP A CE3 1 
ATOM   4103 C  CZ2 . TRP A 1 554 ? -17.971 -53.418 -29.759 1.00 22.41  ? 817  TRP A CZ2 1 
ATOM   4104 C  CZ3 . TRP A 1 554 ? -16.963 -53.211 -31.962 1.00 24.74  ? 817  TRP A CZ3 1 
ATOM   4105 C  CH2 . TRP A 1 554 ? -16.959 -52.968 -30.581 1.00 25.14  ? 817  TRP A CH2 1 
ATOM   4106 N  N   . ILE A 1 555 ? -22.703 -54.968 -36.188 1.00 31.19  ? 818  ILE A N   1 
ATOM   4107 C  CA  . ILE A 1 555 ? -22.892 -55.436 -37.600 1.00 32.68  ? 818  ILE A CA  1 
ATOM   4108 C  C   . ILE A 1 555 ? -23.739 -54.393 -38.339 1.00 36.40  ? 818  ILE A C   1 
ATOM   4109 O  O   . ILE A 1 555 ? -23.180 -53.682 -39.229 1.00 31.24  ? 818  ILE A O   1 
ATOM   4110 C  CB  . ILE A 1 555 ? -23.526 -56.839 -37.684 1.00 35.86  ? 818  ILE A CB  1 
ATOM   4111 C  CG1 . ILE A 1 555 ? -22.815 -57.901 -36.832 1.00 34.62  ? 818  ILE A CG1 1 
ATOM   4112 C  CG2 . ILE A 1 555 ? -23.630 -57.290 -39.138 1.00 35.49  ? 818  ILE A CG2 1 
ATOM   4113 C  CD1 . ILE A 1 555 ? -21.445 -58.164 -37.249 1.00 37.25  ? 818  ILE A CD1 1 
ATOM   4114 N  N   . GLN A 1 556 ? -25.028 -54.275 -37.976 1.00 41.07  ? 819  GLN A N   1 
ATOM   4115 C  CA  . GLN A 1 556 ? -26.049 -53.552 -38.797 1.00 40.25  ? 819  GLN A CA  1 
ATOM   4116 C  C   . GLN A 1 556 ? -25.603 -52.102 -38.977 1.00 37.34  ? 819  GLN A C   1 
ATOM   4117 O  O   . GLN A 1 556 ? -25.423 -51.705 -40.109 1.00 35.22  ? 819  GLN A O   1 
ATOM   4118 C  CB  . GLN A 1 556 ? -27.437 -53.679 -38.169 1.00 44.15  ? 819  GLN A CB  1 
ATOM   4119 C  CG  . GLN A 1 556 ? -28.566 -53.121 -39.039 1.00 54.03  ? 819  GLN A CG  1 
ATOM   4120 C  CD  . GLN A 1 556 ? -29.834 -52.856 -38.245 1.00 62.10  ? 819  GLN A CD  1 
ATOM   4121 O  OE1 . GLN A 1 556 ? -30.390 -51.753 -38.285 1.00 65.20  ? 819  GLN A OE1 1 
ATOM   4122 N  NE2 . GLN A 1 556 ? -30.290 -53.852 -37.486 1.00 54.66  ? 819  GLN A NE2 1 
ATOM   4123 N  N   . GLU A 1 557 ? -25.340 -51.392 -37.876 1.00 35.48  ? 820  GLU A N   1 
ATOM   4124 C  CA  . GLU A 1 557 ? -25.086 -49.933 -37.870 1.00 38.09  ? 820  GLU A CA  1 
ATOM   4125 C  C   . GLU A 1 557 ? -23.580 -49.616 -37.972 1.00 39.79  ? 820  GLU A C   1 
ATOM   4126 O  O   . GLU A 1 557 ? -23.233 -48.431 -37.843 1.00 36.78  ? 820  GLU A O   1 
ATOM   4127 C  CB  . GLU A 1 557 ? -25.661 -49.318 -36.595 1.00 36.37  ? 820  GLU A CB  1 
ATOM   4128 C  CG  . GLU A 1 557 ? -27.160 -49.516 -36.431 1.00 42.95  ? 820  GLU A CG  1 
ATOM   4129 C  CD  . GLU A 1 557 ? -27.722 -48.846 -35.172 1.00 52.34  ? 820  GLU A CD  1 
ATOM   4130 O  OE1 . GLU A 1 557 ? -26.931 -48.646 -34.177 1.00 60.31  ? 820  GLU A OE1 1 
ATOM   4131 O  OE2 . GLU A 1 557 ? -28.953 -48.548 -35.153 1.00 65.63  ? 820  GLU A OE2 1 
ATOM   4132 N  N   . ASN A 1 558 ? -22.712 -50.619 -38.147 1.00 37.01  ? 821  ASN A N   1 
ATOM   4133 C  CA  . ASN A 1 558 ? -21.234 -50.448 -38.100 1.00 33.44  ? 821  ASN A CA  1 
ATOM   4134 C  C   . ASN A 1 558 ? -20.752 -50.065 -39.492 1.00 32.05  ? 821  ASN A C   1 
ATOM   4135 O  O   . ASN A 1 558 ? -20.637 -50.915 -40.359 1.00 31.99  ? 821  ASN A O   1 
ATOM   4136 C  CB  . ASN A 1 558 ? -20.568 -51.720 -37.579 1.00 31.32  ? 821  ASN A CB  1 
ATOM   4137 C  CG  . ASN A 1 558 ? -19.059 -51.685 -37.491 1.00 30.42  ? 821  ASN A CG  1 
ATOM   4138 O  OD1 . ASN A 1 558 ? -18.436 -50.812 -38.064 1.00 27.61  ? 821  ASN A OD1 1 
ATOM   4139 N  ND2 . ASN A 1 558 ? -18.460 -52.702 -36.861 1.00 29.91  ? 821  ASN A ND2 1 
ATOM   4140 N  N   . PRO A 1 559 ? -20.364 -48.804 -39.737 1.00 32.65  ? 822  PRO A N   1 
ATOM   4141 C  CA  . PRO A 1 559 ? -19.948 -48.406 -41.076 1.00 36.78  ? 822  PRO A CA  1 
ATOM   4142 C  C   . PRO A 1 559 ? -18.670 -49.093 -41.579 1.00 36.36  ? 822  PRO A C   1 
ATOM   4143 O  O   . PRO A 1 559 ? -18.406 -49.033 -42.771 1.00 39.12  ? 822  PRO A O   1 
ATOM   4144 C  CB  . PRO A 1 559 ? -19.781 -46.876 -40.966 1.00 38.76  ? 822  PRO A CB  1 
ATOM   4145 C  CG  . PRO A 1 559 ? -19.519 -46.636 -39.489 1.00 38.45  ? 822  PRO A CG  1 
ATOM   4146 C  CD  . PRO A 1 559 ? -20.353 -47.688 -38.775 1.00 35.97  ? 822  PRO A CD  1 
ATOM   4147 N  N   . TRP A 1 560 ? -17.897 -49.742 -40.713 1.00 33.18  ? 823  TRP A N   1 
ATOM   4148 C  CA  . TRP A 1 560 ? -16.632 -50.422 -41.120 1.00 34.75  ? 823  TRP A CA  1 
ATOM   4149 C  C   . TRP A 1 560 ? -16.849 -51.896 -41.554 1.00 36.22  ? 823  TRP A C   1 
ATOM   4150 O  O   . TRP A 1 560 ? -15.881 -52.526 -41.926 1.00 39.21  ? 823  TRP A O   1 
ATOM   4151 C  CB  . TRP A 1 560 ? -15.627 -50.284 -39.963 1.00 35.56  ? 823  TRP A CB  1 
ATOM   4152 C  CG  . TRP A 1 560 ? -15.130 -48.879 -39.829 1.00 30.04  ? 823  TRP A CG  1 
ATOM   4153 C  CD1 . TRP A 1 560 ? -14.193 -48.262 -40.613 1.00 26.95  ? 823  TRP A CD1 1 
ATOM   4154 C  CD2 . TRP A 1 560 ? -15.611 -47.882 -38.915 1.00 29.69  ? 823  TRP A CD2 1 
ATOM   4155 N  NE1 . TRP A 1 560 ? -14.034 -46.960 -40.212 1.00 29.21  ? 823  TRP A NE1 1 
ATOM   4156 C  CE2 . TRP A 1 560 ? -14.894 -46.694 -39.177 1.00 28.49  ? 823  TRP A CE2 1 
ATOM   4157 C  CE3 . TRP A 1 560 ? -16.519 -47.901 -37.861 1.00 27.95  ? 823  TRP A CE3 1 
ATOM   4158 C  CZ2 . TRP A 1 560 ? -15.035 -45.548 -38.412 1.00 25.91  ? 823  TRP A CZ2 1 
ATOM   4159 C  CZ3 . TRP A 1 560 ? -16.747 -46.732 -37.182 1.00 29.12  ? 823  TRP A CZ3 1 
ATOM   4160 C  CH2 . TRP A 1 560 ? -15.999 -45.577 -37.443 1.00 27.52  ? 823  TRP A CH2 1 
ATOM   4161 N  N   . MET A 1 561 ? -18.081 -52.414 -41.534 1.00 35.36  ? 824  MET A N   1 
ATOM   4162 C  CA  . MET A 1 561 ? -18.440 -53.847 -41.738 1.00 41.29  ? 824  MET A CA  1 
ATOM   4163 C  C   . MET A 1 561 ? -19.258 -53.885 -43.027 1.00 37.66  ? 824  MET A C   1 
ATOM   4164 O  O   . MET A 1 561 ? -20.351 -53.320 -43.045 1.00 36.19  ? 824  MET A O   1 
ATOM   4165 C  CB  . MET A 1 561 ? -19.281 -54.343 -40.552 1.00 41.42  ? 824  MET A CB  1 
ATOM   4166 C  CG  . MET A 1 561 ? -19.480 -55.832 -40.468 1.00 45.88  ? 824  MET A CG  1 
ATOM   4167 S  SD  . MET A 1 561 ? -17.978 -56.593 -39.909 1.00 61.72  ? 824  MET A SD  1 
ATOM   4168 C  CE  . MET A 1 561 ? -18.186 -56.522 -38.128 1.00 54.26  ? 824  MET A CE  1 
ATOM   4169 N  N   . GLU A 1 562 ? -18.699 -54.387 -44.117 1.00 43.43  ? 825  GLU A N   1 
ATOM   4170 C  CA  . GLU A 1 562 ? -19.428 -54.406 -45.416 1.00 45.45  ? 825  GLU A CA  1 
ATOM   4171 C  C   . GLU A 1 562 ? -20.478 -55.531 -45.400 1.00 40.40  ? 825  GLU A C   1 
ATOM   4172 O  O   . GLU A 1 562 ? -21.581 -55.283 -45.835 1.00 39.11  ? 825  GLU A O   1 
ATOM   4173 C  CB  . GLU A 1 562 ? -18.467 -54.561 -46.585 1.00 47.71  ? 825  GLU A CB  1 
ATOM   4174 C  CG  . GLU A 1 562 ? -19.049 -54.063 -47.890 1.00 65.09  ? 825  GLU A CG  1 
ATOM   4175 C  CD  . GLU A 1 562 ? -18.096 -54.110 -49.079 1.00 79.40  ? 825  GLU A CD  1 
ATOM   4176 O  OE1 . GLU A 1 562 ? -18.598 -54.195 -50.228 1.00 88.94  ? 825  GLU A OE1 1 
ATOM   4177 O  OE2 . GLU A 1 562 ? -16.853 -54.022 -48.867 1.00 87.20  ? 825  GLU A OE2 1 
ATOM   4178 N  N   . ASP A 1 563 ? -20.141 -56.718 -44.920 1.00 41.47  ? 826  ASP A N   1 
ATOM   4179 C  CA  . ASP A 1 563 ? -21.055 -57.893 -44.864 1.00 41.56  ? 826  ASP A CA  1 
ATOM   4180 C  C   . ASP A 1 563 ? -21.985 -57.776 -43.652 1.00 43.95  ? 826  ASP A C   1 
ATOM   4181 O  O   . ASP A 1 563 ? -21.470 -57.744 -42.515 1.00 41.24  ? 826  ASP A O   1 
ATOM   4182 C  CB  . ASP A 1 563 ? -20.210 -59.154 -44.782 1.00 39.84  ? 826  ASP A CB  1 
ATOM   4183 C  CG  . ASP A 1 563 ? -20.989 -60.426 -44.513 1.00 38.17  ? 826  ASP A CG  1 
ATOM   4184 O  OD1 . ASP A 1 563 ? -22.229 -60.383 -44.502 1.00 35.80  ? 826  ASP A OD1 1 
ATOM   4185 O  OD2 . ASP A 1 563 ? -20.332 -61.415 -44.219 1.00 40.25  ? 826  ASP A OD2 1 
ATOM   4186 N  N   . LYS A 1 564 ? -23.300 -57.729 -43.878 1.00 42.68  ? 827  LYS A N   1 
ATOM   4187 C  CA  . LYS A 1 564 ? -24.302 -57.393 -42.829 1.00 39.89  ? 827  LYS A CA  1 
ATOM   4188 C  C   . LYS A 1 564 ? -24.961 -58.677 -42.302 1.00 36.05  ? 827  LYS A C   1 
ATOM   4189 O  O   . LYS A 1 564 ? -26.023 -58.568 -41.646 1.00 32.91  ? 827  LYS A O   1 
ATOM   4190 C  CB  . LYS A 1 564 ? -25.358 -56.401 -43.350 1.00 43.28  ? 827  LYS A CB  1 
ATOM   4191 C  CG  . LYS A 1 564 ? -24.846 -55.018 -43.745 1.00 43.02  ? 827  LYS A CG  1 
ATOM   4192 C  CD  . LYS A 1 564 ? -23.925 -54.370 -42.730 1.00 40.34  ? 827  LYS A CD  1 
ATOM   4193 C  CE  . LYS A 1 564 ? -23.879 -52.867 -42.839 1.00 40.84  ? 827  LYS A CE  1 
ATOM   4194 N  NZ  . LYS A 1 564 ? -22.951 -52.273 -41.843 1.00 41.00  ? 827  LYS A NZ  1 
ATOM   4195 N  N   . THR A 1 565 ? -24.345 -59.840 -42.525 1.00 36.26  ? 828  THR A N   1 
ATOM   4196 C  CA  . THR A 1 565 ? -24.909 -61.161 -42.102 1.00 39.96  ? 828  THR A CA  1 
ATOM   4197 C  C   . THR A 1 565 ? -25.048 -61.209 -40.588 1.00 37.64  ? 828  THR A C   1 
ATOM   4198 O  O   . THR A 1 565 ? -24.039 -61.113 -39.892 1.00 37.85  ? 828  THR A O   1 
ATOM   4199 C  CB  . THR A 1 565 ? -24.017 -62.330 -42.527 1.00 42.19  ? 828  THR A CB  1 
ATOM   4200 O  OG1 . THR A 1 565 ? -23.804 -62.197 -43.924 1.00 48.13  ? 828  THR A OG1 1 
ATOM   4201 C  CG2 . THR A 1 565 ? -24.607 -63.691 -42.241 1.00 45.60  ? 828  THR A CG2 1 
ATOM   4202 N  N   . PRO A 1 566 ? -26.271 -61.350 -40.019 1.00 43.24  ? 829  PRO A N   1 
ATOM   4203 C  CA  . PRO A 1 566 ? -26.427 -61.301 -38.565 1.00 39.36  ? 829  PRO A CA  1 
ATOM   4204 C  C   . PRO A 1 566 ? -25.680 -62.469 -37.924 1.00 40.24  ? 829  PRO A C   1 
ATOM   4205 O  O   . PRO A 1 566 ? -25.510 -63.505 -38.543 1.00 37.58  ? 829  PRO A O   1 
ATOM   4206 C  CB  . PRO A 1 566 ? -27.939 -61.409 -38.342 1.00 39.56  ? 829  PRO A CB  1 
ATOM   4207 C  CG  . PRO A 1 566 ? -28.536 -60.984 -39.680 1.00 38.99  ? 829  PRO A CG  1 
ATOM   4208 C  CD  . PRO A 1 566 ? -27.565 -61.529 -40.707 1.00 38.42  ? 829  PRO A CD  1 
ATOM   4209 N  N   . VAL A 1 567 ? -25.232 -62.270 -36.699 1.00 39.40  ? 830  VAL A N   1 
ATOM   4210 C  CA  . VAL A 1 567 ? -24.661 -63.366 -35.877 1.00 42.38  ? 830  VAL A CA  1 
ATOM   4211 C  C   . VAL A 1 567 ? -25.870 -64.034 -35.199 1.00 42.69  ? 830  VAL A C   1 
ATOM   4212 O  O   . VAL A 1 567 ? -26.778 -63.283 -34.767 1.00 40.72  ? 830  VAL A O   1 
ATOM   4213 C  CB  . VAL A 1 567 ? -23.617 -62.777 -34.904 1.00 44.08  ? 830  VAL A CB  1 
ATOM   4214 C  CG1 . VAL A 1 567 ? -23.555 -63.517 -33.595 1.00 44.26  ? 830  VAL A CG1 1 
ATOM   4215 C  CG2 . VAL A 1 567 ? -22.245 -62.672 -35.530 1.00 38.73  ? 830  VAL A CG2 1 
ATOM   4216 N  N   . GLU A 1 568 ? -25.893 -65.374 -35.137 1.00 39.87  ? 831  GLU A N   1 
ATOM   4217 C  CA  . GLU A 1 568 ? -27.063 -66.197 -34.695 1.00 43.80  ? 831  GLU A CA  1 
ATOM   4218 C  C   . GLU A 1 568 ? -26.894 -66.654 -33.242 1.00 39.39  ? 831  GLU A C   1 
ATOM   4219 O  O   . GLU A 1 568 ? -27.885 -67.044 -32.658 1.00 38.24  ? 831  GLU A O   1 
ATOM   4220 C  CB  . GLU A 1 568 ? -27.232 -67.456 -35.569 1.00 44.15  ? 831  GLU A CB  1 
ATOM   4221 C  CG  . GLU A 1 568 ? -27.591 -67.161 -37.027 1.00 48.14  ? 831  GLU A CG  1 
ATOM   4222 C  CD  . GLU A 1 568 ? -28.927 -66.450 -37.191 1.00 50.66  ? 831  GLU A CD  1 
ATOM   4223 O  OE1 . GLU A 1 568 ? -29.771 -66.600 -36.301 1.00 51.54  ? 831  GLU A OE1 1 
ATOM   4224 O  OE2 . GLU A 1 568 ? -29.121 -65.730 -38.188 1.00 51.92  ? 831  GLU A OE2 1 
ATOM   4225 N  N   . SER A 1 569 ? -25.677 -66.692 -32.701 1.00 34.06  ? 832  SER A N   1 
ATOM   4226 C  CA  . SER A 1 569 ? -25.445 -67.039 -31.284 1.00 34.62  ? 832  SER A CA  1 
ATOM   4227 C  C   . SER A 1 569 ? -24.182 -66.367 -30.751 1.00 34.87  ? 832  SER A C   1 
ATOM   4228 O  O   . SER A 1 569 ? -23.290 -65.937 -31.527 1.00 32.53  ? 832  SER A O   1 
ATOM   4229 C  CB  . SER A 1 569 ? -25.343 -68.514 -31.104 1.00 33.90  ? 832  SER A CB  1 
ATOM   4230 O  OG  . SER A 1 569 ? -24.118 -68.954 -31.621 1.00 35.15  ? 832  SER A OG  1 
ATOM   4231 N  N   . TRP A 1 570 ? -24.084 -66.348 -29.440 1.00 31.73  ? 833  TRP A N   1 
ATOM   4232 C  CA  . TRP A 1 570 ? -22.913 -65.768 -28.745 1.00 36.16  ? 833  TRP A CA  1 
ATOM   4233 C  C   . TRP A 1 570 ? -21.633 -66.544 -29.111 1.00 36.84  ? 833  TRP A C   1 
ATOM   4234 O  O   . TRP A 1 570 ? -20.575 -65.976 -29.052 1.00 33.61  ? 833  TRP A O   1 
ATOM   4235 C  CB  . TRP A 1 570 ? -23.185 -65.719 -27.235 1.00 29.71  ? 833  TRP A CB  1 
ATOM   4236 C  CG  . TRP A 1 570 ? -24.069 -64.585 -26.820 1.00 36.77  ? 833  TRP A CG  1 
ATOM   4237 C  CD1 . TRP A 1 570 ? -25.403 -64.640 -26.518 1.00 34.98  ? 833  TRP A CD1 1 
ATOM   4238 C  CD2 . TRP A 1 570 ? -23.686 -63.196 -26.669 1.00 39.24  ? 833  TRP A CD2 1 
ATOM   4239 N  NE1 . TRP A 1 570 ? -25.859 -63.398 -26.155 1.00 35.90  ? 833  TRP A NE1 1 
ATOM   4240 C  CE2 . TRP A 1 570 ? -24.836 -62.491 -26.253 1.00 33.95  ? 833  TRP A CE2 1 
ATOM   4241 C  CE3 . TRP A 1 570 ? -22.489 -62.482 -26.842 1.00 39.16  ? 833  TRP A CE3 1 
ATOM   4242 C  CZ2 . TRP A 1 570 ? -24.816 -61.123 -25.981 1.00 37.55  ? 833  TRP A CZ2 1 
ATOM   4243 C  CZ3 . TRP A 1 570 ? -22.475 -61.129 -26.580 1.00 38.96  ? 833  TRP A CZ3 1 
ATOM   4244 C  CH2 . TRP A 1 570 ? -23.630 -60.456 -26.166 1.00 38.82  ? 833  TRP A CH2 1 
ATOM   4245 N  N   . GLU A 1 571 ? -21.778 -67.813 -29.501 0.50 37.86  ? 834  GLU A N   1 
ATOM   4246 C  CA  . GLU A 1 571 ? -20.645 -68.730 -29.779 0.50 41.41  ? 834  GLU A CA  1 
ATOM   4247 C  C   . GLU A 1 571 ? -19.889 -68.249 -31.028 0.50 38.71  ? 834  GLU A C   1 
ATOM   4248 O  O   . GLU A 1 571 ? -18.701 -68.574 -31.139 0.50 38.88  ? 834  GLU A O   1 
ATOM   4249 C  CB  . GLU A 1 571 ? -21.175 -70.165 -29.877 0.50 47.30  ? 834  GLU A CB  1 
ATOM   4250 C  CG  . GLU A 1 571 ? -21.606 -70.744 -28.530 0.50 51.32  ? 834  GLU A CG  1 
ATOM   4251 C  CD  . GLU A 1 571 ? -22.559 -71.935 -28.572 0.50 58.23  ? 834  GLU A CD  1 
ATOM   4252 O  OE1 . GLU A 1 571 ? -22.806 -72.465 -29.683 0.50 59.65  ? 834  GLU A OE1 1 
ATOM   4253 O  OE2 . GLU A 1 571 ? -23.062 -72.337 -27.487 0.50 62.39  ? 834  GLU A OE2 1 
ATOM   4254 N  N   . GLU A 1 572 ? -20.540 -67.484 -31.910 0.50 38.03  ? 835  GLU A N   1 
ATOM   4255 C  CA  . GLU A 1 572 ? -19.926 -66.893 -33.138 0.50 38.96  ? 835  GLU A CA  1 
ATOM   4256 C  C   . GLU A 1 572 ? -19.131 -65.619 -32.794 0.50 37.17  ? 835  GLU A C   1 
ATOM   4257 O  O   . GLU A 1 572 ? -18.548 -65.007 -33.733 0.50 34.27  ? 835  GLU A O   1 
ATOM   4258 C  CB  . GLU A 1 572 ? -20.997 -66.519 -34.170 0.50 40.62  ? 835  GLU A CB  1 
ATOM   4259 C  CG  . GLU A 1 572 ? -21.842 -67.686 -34.663 0.50 43.41  ? 835  GLU A CG  1 
ATOM   4260 C  CD  . GLU A 1 572 ? -22.895 -67.335 -35.713 0.50 44.31  ? 835  GLU A CD  1 
ATOM   4261 O  OE1 . GLU A 1 572 ? -22.800 -66.250 -36.329 0.50 43.33  ? 835  GLU A OE1 1 
ATOM   4262 O  OE2 . GLU A 1 572 ? -23.816 -68.150 -35.915 0.50 47.46  ? 835  GLU A OE2 1 
ATOM   4263 N  N   . ILE A 1 573 ? -19.180 -65.173 -31.534 1.00 33.82  ? 836  ILE A N   1 
ATOM   4264 C  CA  . ILE A 1 573 ? -18.535 -63.904 -31.100 1.00 34.47  ? 836  ILE A CA  1 
ATOM   4265 C  C   . ILE A 1 573 ? -17.255 -64.291 -30.366 1.00 33.98  ? 836  ILE A C   1 
ATOM   4266 O  O   . ILE A 1 573 ? -17.258 -64.926 -29.294 1.00 28.27  ? 836  ILE A O   1 
ATOM   4267 C  CB  . ILE A 1 573 ? -19.513 -63.031 -30.274 1.00 34.39  ? 836  ILE A CB  1 
ATOM   4268 C  CG1 . ILE A 1 573 ? -20.705 -62.561 -31.120 1.00 32.20  ? 836  ILE A CG1 1 
ATOM   4269 C  CG2 . ILE A 1 573 ? -18.758 -61.852 -29.682 1.00 33.12  ? 836  ILE A CG2 1 
ATOM   4270 C  CD1 . ILE A 1 573 ? -21.874 -61.992 -30.328 1.00 30.04  ? 836  ILE A CD1 1 
ATOM   4271 N  N   . PRO A 1 574 ? -16.109 -63.875 -30.927 1.00 32.74  ? 837  PRO A N   1 
ATOM   4272 C  CA  . PRO A 1 574 ? -14.803 -64.304 -30.418 1.00 33.44  ? 837  PRO A CA  1 
ATOM   4273 C  C   . PRO A 1 574 ? -14.287 -63.599 -29.154 1.00 27.49  ? 837  PRO A C   1 
ATOM   4274 O  O   . PRO A 1 574 ? -14.812 -62.586 -28.780 1.00 26.81  ? 837  PRO A O   1 
ATOM   4275 C  CB  . PRO A 1 574 ? -13.884 -63.947 -31.587 1.00 33.73  ? 837  PRO A CB  1 
ATOM   4276 C  CG  . PRO A 1 574 ? -14.522 -62.689 -32.141 1.00 38.58  ? 837  PRO A CG  1 
ATOM   4277 C  CD  . PRO A 1 574 ? -16.022 -62.901 -32.019 1.00 34.21  ? 837  PRO A CD  1 
ATOM   4278 N  N   . TYR A 1 575 ? -13.286 -64.200 -28.518 1.00 29.57  ? 838  TYR A N   1 
ATOM   4279 C  CA  . TYR A 1 575 ? -12.486 -63.637 -27.405 1.00 29.97  ? 838  TYR A CA  1 
ATOM   4280 C  C   . TYR A 1 575 ? -11.111 -63.184 -27.930 1.00 30.34  ? 838  TYR A C   1 
ATOM   4281 O  O   . TYR A 1 575 ? -10.669 -63.619 -28.998 1.00 27.19  ? 838  TYR A O   1 
ATOM   4282 C  CB  . TYR A 1 575 ? -12.294 -64.701 -26.332 1.00 30.60  ? 838  TYR A CB  1 
ATOM   4283 C  CG  . TYR A 1 575 ? -13.532 -65.220 -25.654 1.00 31.64  ? 838  TYR A CG  1 
ATOM   4284 C  CD1 . TYR A 1 575 ? -14.159 -64.510 -24.641 1.00 30.31  ? 838  TYR A CD1 1 
ATOM   4285 C  CD2 . TYR A 1 575 ? -14.065 -66.451 -25.997 1.00 36.31  ? 838  TYR A CD2 1 
ATOM   4286 C  CE1 . TYR A 1 575 ? -15.272 -65.014 -23.987 1.00 31.30  ? 838  TYR A CE1 1 
ATOM   4287 C  CE2 . TYR A 1 575 ? -15.171 -66.974 -25.348 1.00 35.71  ? 838  TYR A CE2 1 
ATOM   4288 C  CZ  . TYR A 1 575 ? -15.782 -66.251 -24.341 1.00 34.69  ? 838  TYR A CZ  1 
ATOM   4289 O  OH  . TYR A 1 575 ? -16.893 -66.748 -23.726 1.00 38.06  ? 838  TYR A OH  1 
ATOM   4290 N  N   . LEU A 1 576 ? -10.420 -62.344 -27.155 1.00 28.53  ? 839  LEU A N   1 
ATOM   4291 C  CA  . LEU A 1 576 ? -8.961  -62.130 -27.265 1.00 28.67  ? 839  LEU A CA  1 
ATOM   4292 C  C   . LEU A 1 576 ? -8.293  -63.506 -27.171 1.00 27.62  ? 839  LEU A C   1 
ATOM   4293 O  O   . LEU A 1 576 ? -8.884  -64.398 -26.550 1.00 27.79  ? 839  LEU A O   1 
ATOM   4294 C  CB  . LEU A 1 576 ? -8.484  -61.229 -26.113 1.00 28.89  ? 839  LEU A CB  1 
ATOM   4295 C  CG  . LEU A 1 576 ? -9.040  -59.803 -26.083 1.00 28.53  ? 839  LEU A CG  1 
ATOM   4296 C  CD1 . LEU A 1 576 ? -8.392  -59.008 -24.967 1.00 28.15  ? 839  LEU A CD1 1 
ATOM   4297 C  CD2 . LEU A 1 576 ? -8.842  -59.086 -27.411 1.00 28.91  ? 839  LEU A CD2 1 
ATOM   4298 N  N   . GLY A 1 577 ? -7.093  -63.654 -27.714 1.00 29.14  ? 840  GLY A N   1 
ATOM   4299 C  CA  . GLY A 1 577 ? -6.168  -64.738 -27.335 1.00 26.54  ? 840  GLY A CA  1 
ATOM   4300 C  C   . GLY A 1 577 ? -6.080  -64.878 -25.819 1.00 24.72  ? 840  GLY A C   1 
ATOM   4301 O  O   . GLY A 1 577 ? -6.220  -63.842 -25.093 1.00 22.98  ? 840  GLY A O   1 
ATOM   4302 N  N   . LYS A 1 578 ? -5.925  -66.115 -25.350 1.00 26.32  ? 841  LYS A N   1 
ATOM   4303 C  CA  . LYS A 1 578 ? -5.855  -66.418 -23.908 1.00 31.43  ? 841  LYS A CA  1 
ATOM   4304 C  C   . LYS A 1 578 ? -4.690  -65.649 -23.307 1.00 26.37  ? 841  LYS A C   1 
ATOM   4305 O  O   . LYS A 1 578 ? -4.877  -65.081 -22.252 1.00 28.74  ? 841  LYS A O   1 
ATOM   4306 C  CB  . LYS A 1 578 ? -5.707  -67.911 -23.643 1.00 39.11  ? 841  LYS A CB  1 
ATOM   4307 C  CG  . LYS A 1 578 ? -5.720  -68.293 -22.155 1.00 45.16  ? 841  LYS A CG  1 
ATOM   4308 C  CD  . LYS A 1 578 ? -5.543  -69.801 -21.915 1.00 54.62  ? 841  LYS A CD  1 
ATOM   4309 C  CE  . LYS A 1 578 ? -4.591  -70.162 -20.783 1.00 59.77  ? 841  LYS A CE  1 
ATOM   4310 N  NZ  . LYS A 1 578 ? -5.195  -71.128 -19.825 1.00 56.13  ? 841  LYS A NZ  1 
ATOM   4311 N  N   . ARG A 1 579 ? -3.561  -65.566 -23.995 1.00 25.40  ? 842  ARG A N   1 
ATOM   4312 C  CA  . ARG A 1 579 ? -2.373  -64.863 -23.462 1.00 27.53  ? 842  ARG A CA  1 
ATOM   4313 C  C   . ARG A 1 579 ? -2.681  -63.372 -23.423 1.00 24.64  ? 842  ARG A C   1 
ATOM   4314 O  O   . ARG A 1 579 ? -2.349  -62.706 -22.373 1.00 25.11  ? 842  ARG A O   1 
ATOM   4315 C  CB  . ARG A 1 579 ? -1.069  -65.227 -24.202 1.00 24.12  ? 842  ARG A CB  1 
ATOM   4316 C  CG  . ARG A 1 579 ? 0.184   -64.715 -23.512 1.00 25.31  ? 842  ARG A CG  1 
ATOM   4317 C  CD  . ARG A 1 579 ? 1.504   -65.088 -24.223 1.00 29.15  ? 842  ARG A CD  1 
ATOM   4318 N  NE  . ARG A 1 579 ? 1.509   -66.537 -24.382 1.00 31.23  ? 842  ARG A NE  1 
ATOM   4319 C  CZ  . ARG A 1 579 ? 1.706   -67.360 -23.374 1.00 36.73  ? 842  ARG A CZ  1 
ATOM   4320 N  NH1 . ARG A 1 579 ? 1.541   -68.659 -23.544 1.00 43.79  ? 842  ARG A NH1 1 
ATOM   4321 N  NH2 . ARG A 1 579 ? 2.045   -66.871 -22.198 1.00 37.72  ? 842  ARG A NH2 1 
ATOM   4322 N  N   . GLU A 1 580 ? -3.247  -62.823 -24.487 1.00 26.28  ? 843  GLU A N   1 
ATOM   4323 C  CA  . GLU A 1 580 ? -3.628  -61.379 -24.499 1.00 28.06  ? 843  GLU A CA  1 
ATOM   4324 C  C   . GLU A 1 580 ? -4.666  -61.095 -23.403 1.00 23.77  ? 843  GLU A C   1 
ATOM   4325 O  O   . GLU A 1 580 ? -4.573  -60.067 -22.758 1.00 25.21  ? 843  GLU A O   1 
ATOM   4326 C  CB  . GLU A 1 580 ? -4.295  -60.934 -25.795 1.00 30.46  ? 843  GLU A CB  1 
ATOM   4327 C  CG  . GLU A 1 580 ? -3.573  -61.323 -27.045 1.00 32.80  ? 843  GLU A CG  1 
ATOM   4328 C  CD  . GLU A 1 580 ? -4.315  -60.785 -28.255 1.00 39.63  ? 843  GLU A CD  1 
ATOM   4329 O  OE1 . GLU A 1 580 ? -5.284  -61.434 -28.720 1.00 40.10  ? 843  GLU A OE1 1 
ATOM   4330 O  OE2 . GLU A 1 580 ? -3.959  -59.688 -28.692 1.00 48.85  ? 843  GLU A OE2 1 
ATOM   4331 N  N   . ASP A 1 581 ? -5.604  -61.993 -23.170 1.00 24.25  ? 844  ASP A N   1 
ATOM   4332 C  CA  . ASP A 1 581 ? -6.627  -61.804 -22.114 1.00 26.41  ? 844  ASP A CA  1 
ATOM   4333 C  C   . ASP A 1 581 ? -5.936  -61.727 -20.753 1.00 27.10  ? 844  ASP A C   1 
ATOM   4334 O  O   . ASP A 1 581 ? -6.278  -60.818 -19.931 1.00 27.06  ? 844  ASP A O   1 
ATOM   4335 C  CB  . ASP A 1 581 ? -7.654  -62.915 -22.198 1.00 25.78  ? 844  ASP A CB  1 
ATOM   4336 C  CG  . ASP A 1 581 ? -9.040  -62.607 -21.666 1.00 27.08  ? 844  ASP A CG  1 
ATOM   4337 O  OD1 . ASP A 1 581 ? -9.240  -61.597 -20.903 1.00 23.29  ? 844  ASP A OD1 1 
ATOM   4338 O  OD2 . ASP A 1 581 ? -9.913  -63.416 -22.021 1.00 27.18  ? 844  ASP A OD2 1 
ATOM   4339 N  N   . GLN A 1 582 ? -4.927  -62.566 -20.522 1.00 25.97  ? 845  GLN A N   1 
ATOM   4340 C  CA  . GLN A 1 582 ? -4.148  -62.546 -19.246 1.00 25.85  ? 845  GLN A CA  1 
ATOM   4341 C  C   . GLN A 1 582 ? -3.353  -61.249 -19.095 1.00 23.80  ? 845  GLN A C   1 
ATOM   4342 O  O   . GLN A 1 582 ? -3.367  -60.602 -18.010 1.00 23.73  ? 845  GLN A O   1 
ATOM   4343 C  CB  . GLN A 1 582 ? -3.193  -63.770 -19.157 1.00 28.36  ? 845  GLN A CB  1 
ATOM   4344 C  CG  . GLN A 1 582 ? -3.908  -65.094 -18.953 1.00 29.91  ? 845  GLN A CG  1 
ATOM   4345 C  CD  . GLN A 1 582 ? -2.977  -66.292 -19.100 1.00 34.51  ? 845  GLN A CD  1 
ATOM   4346 O  OE1 . GLN A 1 582 ? -1.921  -66.202 -19.670 1.00 34.13  ? 845  GLN A OE1 1 
ATOM   4347 N  NE2 . GLN A 1 582 ? -3.329  -67.428 -18.528 1.00 35.10  ? 845  GLN A NE2 1 
ATOM   4348 N  N   . TRP A 1 583 ? -2.645  -60.854 -20.137 1.00 22.79  ? 846  TRP A N   1 
ATOM   4349 C  CA  . TRP A 1 583 ? -1.931  -59.551 -20.193 1.00 23.31  ? 846  TRP A CA  1 
ATOM   4350 C  C   . TRP A 1 583 ? -2.849  -58.390 -19.753 1.00 27.29  ? 846  TRP A C   1 
ATOM   4351 O  O   . TRP A 1 583 ? -2.352  -57.484 -19.041 1.00 24.56  ? 846  TRP A O   1 
ATOM   4352 C  CB  . TRP A 1 583 ? -1.380  -59.296 -21.607 1.00 23.43  ? 846  TRP A CB  1 
ATOM   4353 C  CG  . TRP A 1 583 ? -0.198  -60.155 -21.950 1.00 25.18  ? 846  TRP A CG  1 
ATOM   4354 C  CD1 . TRP A 1 583 ? 0.615   -60.833 -21.088 1.00 25.64  ? 846  TRP A CD1 1 
ATOM   4355 C  CD2 . TRP A 1 583 ? 0.322   -60.420 -23.262 1.00 24.84  ? 846  TRP A CD2 1 
ATOM   4356 N  NE1 . TRP A 1 583 ? 1.587   -61.507 -21.779 1.00 26.79  ? 846  TRP A NE1 1 
ATOM   4357 C  CE2 . TRP A 1 583 ? 1.421   -61.284 -23.115 1.00 25.87  ? 846  TRP A CE2 1 
ATOM   4358 C  CE3 . TRP A 1 583 ? -0.055  -60.044 -24.546 1.00 26.77  ? 846  TRP A CE3 1 
ATOM   4359 C  CZ2 . TRP A 1 583 ? 2.175   -61.726 -24.210 1.00 29.75  ? 846  TRP A CZ2 1 
ATOM   4360 C  CZ3 . TRP A 1 583 ? 0.673   -60.495 -25.629 1.00 29.67  ? 846  TRP A CZ3 1 
ATOM   4361 C  CH2 . TRP A 1 583 ? 1.770   -61.333 -25.467 1.00 29.25  ? 846  TRP A CH2 1 
ATOM   4362 N  N   . CYS A 1 584 ? -4.118  -58.356 -20.218 1.00 24.15  ? 847  CYS A N   1 
ATOM   4363 C  CA  . CYS A 1 584 ? -5.073  -57.276 -19.874 1.00 22.42  ? 847  CYS A CA  1 
ATOM   4364 C  C   . CYS A 1 584 ? -5.822  -57.582 -18.573 1.00 21.76  ? 847  CYS A C   1 
ATOM   4365 O  O   . CYS A 1 584 ? -6.889  -57.013 -18.397 1.00 22.09  ? 847  CYS A O   1 
ATOM   4366 C  CB  . CYS A 1 584 ? -5.986  -57.002 -21.053 1.00 23.54  ? 847  CYS A CB  1 
ATOM   4367 S  SG  . CYS A 1 584 ? -5.028  -56.239 -22.366 1.00 24.67  ? 847  CYS A SG  1 
ATOM   4368 N  N   . GLY A 1 585 ? -5.343  -58.553 -17.779 1.00 26.12  ? 848  GLY A N   1 
ATOM   4369 C  CA  . GLY A 1 585 ? -5.747  -58.730 -16.372 1.00 22.43  ? 848  GLY A CA  1 
ATOM   4370 C  C   . GLY A 1 585 ? -6.599  -59.945 -16.079 1.00 24.71  ? 848  GLY A C   1 
ATOM   4371 O  O   . GLY A 1 585 ? -7.004  -60.064 -14.918 1.00 25.66  ? 848  GLY A O   1 
ATOM   4372 N  N   . SER A 1 586 ? -6.953  -60.796 -17.062 1.00 23.13  ? 849  SER A N   1 
ATOM   4373 C  CA  . SER A 1 586 ? -7.813  -61.987 -16.830 1.00 23.29  ? 849  SER A CA  1 
ATOM   4374 C  C   . SER A 1 586 ? -7.200  -62.866 -15.734 1.00 25.23  ? 849  SER A C   1 
ATOM   4375 O  O   . SER A 1 586 ? -5.972  -63.016 -15.734 1.00 21.90  ? 849  SER A O   1 
ATOM   4376 C  CB  . SER A 1 586 ? -7.947  -62.783 -18.101 1.00 24.36  ? 849  SER A CB  1 
ATOM   4377 O  OG  . SER A 1 586 ? -8.710  -63.953 -17.839 1.00 23.45  ? 849  SER A OG  1 
ATOM   4378 N  N   . LEU A 1 587 ? -8.045  -63.524 -14.947 1.00 24.15  ? 850  LEU A N   1 
ATOM   4379 C  CA  . LEU A 1 587 ? -7.647  -64.527 -13.930 1.00 26.08  ? 850  LEU A CA  1 
ATOM   4380 C  C   . LEU A 1 587 ? -7.704  -65.939 -14.534 1.00 27.50  ? 850  LEU A C   1 
ATOM   4381 O  O   . LEU A 1 587 ? -7.534  -66.897 -13.754 1.00 27.77  ? 850  LEU A O   1 
ATOM   4382 C  CB  . LEU A 1 587 ? -8.598  -64.430 -12.727 1.00 23.51  ? 850  LEU A CB  1 
ATOM   4383 C  CG  . LEU A 1 587 ? -8.568  -63.119 -11.956 1.00 27.12  ? 850  LEU A CG  1 
ATOM   4384 C  CD1 . LEU A 1 587 ? -9.217  -63.274 -10.569 1.00 25.74  ? 850  LEU A CD1 1 
ATOM   4385 C  CD2 . LEU A 1 587 ? -7.157  -62.606 -11.785 1.00 29.88  ? 850  LEU A CD2 1 
ATOM   4386 N  N   . ILE A 1 588 ? -8.008  -66.083 -15.827 1.00 25.77  ? 851  ILE A N   1 
ATOM   4387 C  CA  . ILE A 1 588 ? -8.041  -67.418 -16.494 1.00 31.69  ? 851  ILE A CA  1 
ATOM   4388 C  C   . ILE A 1 588 ? -6.709  -68.124 -16.189 1.00 27.81  ? 851  ILE A C   1 
ATOM   4389 O  O   . ILE A 1 588 ? -5.636  -67.472 -16.254 1.00 27.33  ? 851  ILE A O   1 
ATOM   4390 C  CB  . ILE A 1 588 ? -8.376  -67.267 -18.007 1.00 34.70  ? 851  ILE A CB  1 
ATOM   4391 C  CG1 . ILE A 1 588 ? -8.768  -68.582 -18.661 1.00 41.20  ? 851  ILE A CG1 1 
ATOM   4392 C  CG2 . ILE A 1 588 ? -7.264  -66.582 -18.798 1.00 31.94  ? 851  ILE A CG2 1 
ATOM   4393 C  CD1 . ILE A 1 588 ? -10.232 -68.929 -18.542 1.00 45.79  ? 851  ILE A CD1 1 
ATOM   4394 N  N   . GLY A 1 589 ? -6.776  -69.395 -15.791 1.00 31.91  ? 852  GLY A N   1 
ATOM   4395 C  CA  . GLY A 1 589 ? -5.599  -70.202 -15.435 1.00 33.93  ? 852  GLY A CA  1 
ATOM   4396 C  C   . GLY A 1 589 ? -5.405  -70.266 -13.937 1.00 36.83  ? 852  GLY A C   1 
ATOM   4397 O  O   . GLY A 1 589 ? -4.727  -71.170 -13.499 1.00 42.29  ? 852  GLY A O   1 
ATOM   4398 N  N   . LEU A 1 590 ? -6.032  -69.395 -13.149 1.00 33.81  ? 853  LEU A N   1 
ATOM   4399 C  CA  . LEU A 1 590 ? -5.959  -69.505 -11.672 1.00 30.15  ? 853  LEU A CA  1 
ATOM   4400 C  C   . LEU A 1 590 ? -7.023  -70.488 -11.161 1.00 37.03  ? 853  LEU A C   1 
ATOM   4401 O  O   . LEU A 1 590 ? -8.138  -70.635 -11.771 1.00 34.19  ? 853  LEU A O   1 
ATOM   4402 C  CB  . LEU A 1 590 ? -6.169  -68.147 -11.001 1.00 32.71  ? 853  LEU A CB  1 
ATOM   4403 C  CG  . LEU A 1 590 ? -5.206  -66.986 -11.291 1.00 35.63  ? 853  LEU A CG  1 
ATOM   4404 C  CD1 . LEU A 1 590 ? -5.504  -65.836 -10.331 1.00 39.85  ? 853  LEU A CD1 1 
ATOM   4405 C  CD2 . LEU A 1 590 ? -3.740  -67.362 -11.181 1.00 35.60  ? 853  LEU A CD2 1 
ATOM   4406 N  N   . THR A 1 591 ? -6.698  -71.109 -10.030 1.00 36.45  ? 854  THR A N   1 
ATOM   4407 C  CA  . THR A 1 591 ? -7.531  -72.079 -9.280  1.00 39.70  ? 854  THR A CA  1 
ATOM   4408 C  C   . THR A 1 591 ? -8.792  -71.382 -8.785  1.00 33.46  ? 854  THR A C   1 
ATOM   4409 O  O   . THR A 1 591 ? -9.877  -71.947 -8.977  1.00 35.67  ? 854  THR A O   1 
ATOM   4410 C  CB  . THR A 1 591 ? -6.702  -72.700 -8.138  1.00 39.14  ? 854  THR A CB  1 
ATOM   4411 O  OG1 . THR A 1 591 ? -5.876  -73.567 -8.887  1.00 47.20  ? 854  THR A OG1 1 
ATOM   4412 C  CG2 . THR A 1 591 ? -7.473  -73.495 -7.112  1.00 45.58  ? 854  THR A CG2 1 
ATOM   4413 N  N   . SER A 1 592 ? -8.656  -70.196 -8.205  1.00 33.71  ? 855  SER A N   1 
ATOM   4414 C  CA  . SER A 1 592 ? -9.803  -69.370 -7.713  1.00 32.51  ? 855  SER A CA  1 
ATOM   4415 C  C   . SER A 1 592 ? -10.854 -69.146 -8.820  1.00 30.99  ? 855  SER A C   1 
ATOM   4416 O  O   . SER A 1 592 ? -12.056 -69.232 -8.543  1.00 34.76  ? 855  SER A O   1 
ATOM   4417 C  CB  . SER A 1 592 ? -9.346  -68.081 -7.057  1.00 33.29  ? 855  SER A CB  1 
ATOM   4418 O  OG  . SER A 1 592 ? -8.695  -67.144 -7.958  1.00 35.94  ? 855  SER A OG  1 
ATOM   4419 N  N   . ARG A 1 593 ? -10.393 -68.888 -10.045 0.50 31.23  ? 856  ARG A N   1 
ATOM   4420 C  CA  . ARG A 1 593 ? -11.236 -68.536 -11.217 0.50 30.56  ? 856  ARG A CA  1 
ATOM   4421 C  C   . ARG A 1 593 ? -11.921 -69.802 -11.757 0.50 32.06  ? 856  ARG A C   1 
ATOM   4422 O  O   . ARG A 1 593 ? -13.120 -69.721 -12.090 0.50 30.39  ? 856  ARG A O   1 
ATOM   4423 C  CB  . ARG A 1 593 ? -10.366 -67.846 -12.270 0.50 30.16  ? 856  ARG A CB  1 
ATOM   4424 C  CG  . ARG A 1 593 ? -11.146 -67.198 -13.405 0.50 30.65  ? 856  ARG A CG  1 
ATOM   4425 C  CD  . ARG A 1 593 ? -11.597 -68.171 -14.479 0.50 30.38  ? 856  ARG A CD  1 
ATOM   4426 N  NE  . ARG A 1 593 ? -12.117 -67.409 -15.604 0.50 31.51  ? 856  ARG A NE  1 
ATOM   4427 C  CZ  . ARG A 1 593 ? -12.891 -67.895 -16.568 0.50 29.82  ? 856  ARG A CZ  1 
ATOM   4428 N  NH1 . ARG A 1 593 ? -13.223 -69.169 -16.561 0.50 30.34  ? 856  ARG A NH1 1 
ATOM   4429 N  NH2 . ARG A 1 593 ? -13.324 -67.107 -17.538 0.50 29.31  ? 856  ARG A NH2 1 
ATOM   4430 N  N   . ALA A 1 594 ? -11.189 -70.920 -11.849 1.00 29.48  ? 857  ALA A N   1 
ATOM   4431 C  CA  . ALA A 1 594 ? -11.739 -72.237 -12.250 1.00 30.30  ? 857  ALA A CA  1 
ATOM   4432 C  C   . ALA A 1 594 ? -12.858 -72.694 -11.270 1.00 31.53  ? 857  ALA A C   1 
ATOM   4433 O  O   . ALA A 1 594 ? -13.888 -73.190 -11.721 1.00 26.18  ? 857  ALA A O   1 
ATOM   4434 C  CB  . ALA A 1 594 ? -10.616 -73.242 -12.270 1.00 33.58  ? 857  ALA A CB  1 
ATOM   4435 N  N   . THR A 1 595 ? -12.696 -72.506 -9.961  1.00 29.64  ? 858  THR A N   1 
ATOM   4436 C  CA  . THR A 1 595 ? -13.722 -72.913 -8.978  1.00 35.02  ? 858  THR A CA  1 
ATOM   4437 C  C   . THR A 1 595 ? -14.943 -72.001 -9.078  1.00 34.93  ? 858  THR A C   1 
ATOM   4438 O  O   . THR A 1 595 ? -16.086 -72.450 -8.895  1.00 35.99  ? 858  THR A O   1 
ATOM   4439 C  CB  . THR A 1 595 ? -13.268 -72.776 -7.527  1.00 35.88  ? 858  THR A CB  1 
ATOM   4440 O  OG1 . THR A 1 595 ? -12.037 -73.476 -7.404  1.00 44.57  ? 858  THR A OG1 1 
ATOM   4441 C  CG2 . THR A 1 595 ? -14.324 -73.351 -6.616  1.00 35.37  ? 858  THR A CG2 1 
ATOM   4442 N  N   . TRP A 1 596 ? -14.693 -70.736 -9.335  1.00 33.38  ? 859  TRP A N   1 
ATOM   4443 C  CA  . TRP A 1 596 ? -15.776 -69.748 -9.562  1.00 30.13  ? 859  TRP A CA  1 
ATOM   4444 C  C   . TRP A 1 596 ? -16.573 -70.163 -10.800 1.00 27.11  ? 859  TRP A C   1 
ATOM   4445 O  O   . TRP A 1 596 ? -17.780 -70.183 -10.707 1.00 28.38  ? 859  TRP A O   1 
ATOM   4446 C  CB  . TRP A 1 596 ? -15.170 -68.339 -9.674  1.00 28.67  ? 859  TRP A CB  1 
ATOM   4447 C  CG  . TRP A 1 596 ? -16.060 -67.245 -10.185 1.00 26.44  ? 859  TRP A CG  1 
ATOM   4448 C  CD1 . TRP A 1 596 ? -17.075 -66.643 -9.518  1.00 25.57  ? 859  TRP A CD1 1 
ATOM   4449 C  CD2 . TRP A 1 596 ? -15.930 -66.548 -11.435 1.00 26.59  ? 859  TRP A CD2 1 
ATOM   4450 N  NE1 . TRP A 1 596 ? -17.571 -65.608 -10.259 1.00 25.03  ? 859  TRP A NE1 1 
ATOM   4451 C  CE2 . TRP A 1 596 ? -16.916 -65.539 -11.451 1.00 26.41  ? 859  TRP A CE2 1 
ATOM   4452 C  CE3 . TRP A 1 596 ? -15.046 -66.635 -12.513 1.00 28.91  ? 859  TRP A CE3 1 
ATOM   4453 C  CZ2 . TRP A 1 596 ? -17.041 -64.609 -12.485 1.00 26.90  ? 859  TRP A CZ2 1 
ATOM   4454 C  CZ3 . TRP A 1 596 ? -15.167 -65.729 -13.554 1.00 32.53  ? 859  TRP A CZ3 1 
ATOM   4455 C  CH2 . TRP A 1 596 ? -16.173 -64.739 -13.547 1.00 32.20  ? 859  TRP A CH2 1 
ATOM   4456 N  N   . ALA A 1 597 ? -15.928 -70.298 -11.956 1.00 29.17  ? 860  ALA A N   1 
ATOM   4457 C  CA  . ALA A 1 597 ? -16.600 -70.665 -13.224 1.00 31.47  ? 860  ALA A CA  1 
ATOM   4458 C  C   . ALA A 1 597 ? -17.395 -71.964 -13.026 1.00 33.21  ? 860  ALA A C   1 
ATOM   4459 O  O   . ALA A 1 597 ? -18.611 -71.976 -13.247 1.00 34.42  ? 860  ALA A O   1 
ATOM   4460 C  CB  . ALA A 1 597 ? -15.574 -70.768 -14.327 1.00 27.81  ? 860  ALA A CB  1 
ATOM   4461 N  N   . LYS A 1 598 ? -16.751 -72.985 -12.473 1.00 37.06  ? 861  LYS A N   1 
ATOM   4462 C  CA  . LYS A 1 598 ? -17.352 -74.331 -12.317 1.00 37.11  ? 861  LYS A CA  1 
ATOM   4463 C  C   . LYS A 1 598 ? -18.602 -74.233 -11.462 1.00 32.62  ? 861  LYS A C   1 
ATOM   4464 O  O   . LYS A 1 598 ? -19.588 -74.863 -11.836 1.00 31.20  ? 861  LYS A O   1 
ATOM   4465 C  CB  . LYS A 1 598 ? -16.321 -75.264 -11.670 1.00 47.34  ? 861  LYS A CB  1 
ATOM   4466 C  CG  . LYS A 1 598 ? -16.754 -76.701 -11.429 1.00 56.00  ? 861  LYS A CG  1 
ATOM   4467 C  CD  . LYS A 1 598 ? -15.624 -77.574 -10.870 1.00 70.28  ? 861  LYS A CD  1 
ATOM   4468 C  CE  . LYS A 1 598 ? -15.491 -78.911 -11.581 1.00 79.92  ? 861  LYS A CE  1 
ATOM   4469 N  NZ  . LYS A 1 598 ? -16.809 -79.565 -11.799 1.00 80.26  ? 861  LYS A NZ  1 
ATOM   4470 N  N   . ASN A 1 599 ? -18.558 -73.492 -10.352 1.00 30.60  ? 862  ASN A N   1 
ATOM   4471 C  CA  . ASN A 1 599 ? -19.660 -73.449 -9.338  1.00 32.88  ? 862  ASN A CA  1 
ATOM   4472 C  C   . ASN A 1 599 ? -20.568 -72.224 -9.510  1.00 32.16  ? 862  ASN A C   1 
ATOM   4473 O  O   . ASN A 1 599 ? -21.192 -71.793 -8.513  1.00 33.59  ? 862  ASN A O   1 
ATOM   4474 C  CB  . ASN A 1 599 ? -19.104 -73.463 -7.910  1.00 32.58  ? 862  ASN A CB  1 
ATOM   4475 C  CG  . ASN A 1 599 ? -18.329 -74.728 -7.636  1.00 37.69  ? 862  ASN A CG  1 
ATOM   4476 O  OD1 . ASN A 1 599 ? -18.779 -75.820 -7.937  1.00 41.66  ? 862  ASN A OD1 1 
ATOM   4477 N  ND2 . ASN A 1 599 ? -17.146 -74.589 -7.100  1.00 44.74  ? 862  ASN A ND2 1 
ATOM   4478 N  N   . ILE A 1 600 ? -20.617 -71.653 -10.709 1.00 31.27  ? 863  ILE A N   1 
ATOM   4479 C  CA  . ILE A 1 600 ? -21.255 -70.318 -10.936 1.00 28.64  ? 863  ILE A CA  1 
ATOM   4480 C  C   . ILE A 1 600 ? -22.763 -70.353 -10.605 1.00 30.08  ? 863  ILE A C   1 
ATOM   4481 O  O   . ILE A 1 600 ? -23.267 -69.368 -10.032 1.00 28.85  ? 863  ILE A O   1 
ATOM   4482 C  CB  . ILE A 1 600 ? -20.972 -69.804 -12.363 1.00 27.69  ? 863  ILE A CB  1 
ATOM   4483 C  CG1 . ILE A 1 600 ? -21.383 -68.343 -12.493 1.00 28.84  ? 863  ILE A CG1 1 
ATOM   4484 C  CG2 . ILE A 1 600 ? -21.601 -70.686 -13.429 1.00 28.81  ? 863  ILE A CG2 1 
ATOM   4485 C  CD1 . ILE A 1 600 ? -20.539 -67.410 -11.657 1.00 27.40  ? 863  ILE A CD1 1 
ATOM   4486 N  N   A GLN A 1 601 ? -23.453 -71.451 -10.934 0.25 28.65  ? 864  GLN A N   1 
ATOM   4487 N  N   B GLN A 1 601 ? -23.455 -71.452 -10.931 0.25 29.14  ? 864  GLN A N   1 
ATOM   4488 C  CA  A GLN A 1 601 ? -24.903 -71.635 -10.647 0.25 29.44  ? 864  GLN A CA  1 
ATOM   4489 C  CA  B GLN A 1 601 ? -24.910 -71.621 -10.655 0.25 30.28  ? 864  GLN A CA  1 
ATOM   4490 C  C   A GLN A 1 601 ? -25.177 -71.509 -9.138  0.25 29.68  ? 864  GLN A C   1 
ATOM   4491 C  C   B GLN A 1 601 ? -25.182 -71.519 -9.140  0.25 30.16  ? 864  GLN A C   1 
ATOM   4492 O  O   A GLN A 1 601 ? -26.268 -71.018 -8.770  0.25 28.46  ? 864  GLN A O   1 
ATOM   4493 O  O   B GLN A 1 601 ? -26.280 -71.044 -8.769  0.25 28.91  ? 864  GLN A O   1 
ATOM   4494 C  CB  A GLN A 1 601 ? -25.395 -72.968 -11.210 0.25 30.03  ? 864  GLN A CB  1 
ATOM   4495 C  CB  B GLN A 1 601 ? -25.426 -72.927 -11.265 0.25 31.50  ? 864  GLN A CB  1 
ATOM   4496 C  CG  A GLN A 1 601 ? -25.381 -73.013 -12.730 0.25 29.18  ? 864  GLN A CG  1 
ATOM   4497 C  CG  B GLN A 1 601 ? -26.942 -73.070 -11.224 0.25 31.05  ? 864  GLN A CG  1 
ATOM   4498 C  CD  A GLN A 1 601 ? -26.340 -72.026 -13.340 0.25 29.35  ? 864  GLN A CD  1 
ATOM   4499 C  CD  B GLN A 1 601 ? -27.670 -71.901 -11.844 0.25 32.97  ? 864  GLN A CD  1 
ATOM   4500 O  OE1 A GLN A 1 601 ? -27.179 -71.445 -12.657 0.25 32.17  ? 864  GLN A OE1 1 
ATOM   4501 O  OE1 B GLN A 1 601 ? -27.396 -71.504 -12.974 0.25 35.24  ? 864  GLN A OE1 1 
ATOM   4502 N  NE2 A GLN A 1 601 ? -26.229 -71.838 -14.644 0.25 29.77  ? 864  GLN A NE2 1 
ATOM   4503 N  NE2 B GLN A 1 601 ? -28.623 -71.351 -11.106 0.25 32.16  ? 864  GLN A NE2 1 
ATOM   4504 N  N   . THR A 1 602 ? -24.229 -71.910 -8.294  1.00 29.32  ? 865  THR A N   1 
ATOM   4505 C  CA  . THR A 1 602 ? -24.362 -71.757 -6.817  1.00 31.47  ? 865  THR A CA  1 
ATOM   4506 C  C   . THR A 1 602 ? -24.271 -70.280 -6.405  1.00 32.50  ? 865  THR A C   1 
ATOM   4507 O  O   . THR A 1 602 ? -24.922 -69.887 -5.424  1.00 31.41  ? 865  THR A O   1 
ATOM   4508 C  CB  . THR A 1 602 ? -23.277 -72.550 -6.098  1.00 33.29  ? 865  THR A CB  1 
ATOM   4509 O  OG1 . THR A 1 602 ? -23.463 -73.894 -6.554  1.00 37.94  ? 865  THR A OG1 1 
ATOM   4510 C  CG2 . THR A 1 602 ? -23.369 -72.418 -4.594  1.00 36.30  ? 865  THR A CG2 1 
ATOM   4511 N  N   . ALA A 1 603 ? -23.504 -69.462 -7.126  1.00 35.94  ? 866  ALA A N   1 
ATOM   4512 C  CA  . ALA A 1 603 ? -23.373 -68.012 -6.839  1.00 33.42  ? 866  ALA A CA  1 
ATOM   4513 C  C   . ALA A 1 603 ? -24.636 -67.326 -7.308  1.00 28.47  ? 866  ALA A C   1 
ATOM   4514 O  O   . ALA A 1 603 ? -25.241 -66.543 -6.537  1.00 24.20  ? 866  ALA A O   1 
ATOM   4515 C  CB  . ALA A 1 603 ? -22.181 -67.416 -7.528  1.00 35.02  ? 866  ALA A CB  1 
ATOM   4516 N  N   . ILE A 1 604 ? -25.098 -67.736 -8.484  1.00 25.71  ? 867  ILE A N   1 
ATOM   4517 C  CA  . ILE A 1 604 ? -26.345 -67.166 -9.064  1.00 26.51  ? 867  ILE A CA  1 
ATOM   4518 C  C   . ILE A 1 604 ? -27.500 -67.468 -8.100  1.00 27.27  ? 867  ILE A C   1 
ATOM   4519 O  O   . ILE A 1 604 ? -28.272 -66.551 -7.750  1.00 24.70  ? 867  ILE A O   1 
ATOM   4520 C  CB  . ILE A 1 604 ? -26.534 -67.751 -10.463 1.00 26.89  ? 867  ILE A CB  1 
ATOM   4521 C  CG1 . ILE A 1 604 ? -25.458 -67.228 -11.423 1.00 26.38  ? 867  ILE A CG1 1 
ATOM   4522 C  CG2 . ILE A 1 604 ? -27.943 -67.495 -10.947 1.00 27.60  ? 867  ILE A CG2 1 
ATOM   4523 C  CD1 . ILE A 1 604 ? -25.471 -67.871 -12.839 1.00 30.92  ? 867  ILE A CD1 1 
ATOM   4524 N  N   . ASN A 1 605 ? -27.550 -68.701 -7.585  1.00 31.30  ? 868  ASN A N   1 
ATOM   4525 C  CA  . ASN A 1 605 ? -28.642 -69.150 -6.683  1.00 30.46  ? 868  ASN A CA  1 
ATOM   4526 C  C   . ASN A 1 605 ? -28.563 -68.343 -5.381  1.00 29.20  ? 868  ASN A C   1 
ATOM   4527 O  O   . ASN A 1 605 ? -29.622 -68.042 -4.866  1.00 30.15  ? 868  ASN A O   1 
ATOM   4528 C  CB  . ASN A 1 605 ? -28.647 -70.671 -6.515  1.00 35.47  ? 868  ASN A CB  1 
ATOM   4529 C  CG  . ASN A 1 605 ? -29.197 -71.411 -7.727  1.00 41.96  ? 868  ASN A CG  1 
ATOM   4530 O  OD1 . ASN A 1 605 ? -29.959 -70.884 -8.532  1.00 47.62  ? 868  ASN A OD1 1 
ATOM   4531 N  ND2 . ASN A 1 605 ? -28.785 -72.648 -7.893  1.00 50.37  ? 868  ASN A ND2 1 
ATOM   4532 N  N   . GLN A 1 606 ? -27.372 -67.987 -4.877  1.00 28.57  ? 869  GLN A N   1 
ATOM   4533 C  CA  . GLN A 1 606 ? -27.262 -67.215 -3.604  1.00 31.44  ? 869  GLN A CA  1 
ATOM   4534 C  C   . GLN A 1 606 ? -27.956 -65.858 -3.775  1.00 30.41  ? 869  GLN A C   1 
ATOM   4535 O  O   . GLN A 1 606 ? -28.676 -65.387 -2.832  1.00 31.22  ? 869  GLN A O   1 
ATOM   4536 C  CB  . GLN A 1 606 ? -25.814 -66.997 -3.145  1.00 32.74  ? 869  GLN A CB  1 
ATOM   4537 C  CG  . GLN A 1 606 ? -25.690 -66.168 -1.846  1.00 38.23  ? 869  GLN A CG  1 
ATOM   4538 C  CD  . GLN A 1 606 ? -24.295 -65.835 -1.335  1.00 43.28  ? 869  GLN A CD  1 
ATOM   4539 O  OE1 . GLN A 1 606 ? -23.328 -65.688 -2.100  1.00 44.46  ? 869  GLN A OE1 1 
ATOM   4540 N  NE2 . GLN A 1 606 ? -24.176 -65.714 -0.016  1.00 43.31  ? 869  GLN A NE2 1 
ATOM   4541 N  N   . VAL A 1 607 ? -27.663 -65.186 -4.885  1.00 25.78  ? 870  VAL A N   1 
ATOM   4542 C  CA  . VAL A 1 607 ? -28.233 -63.855 -5.187  1.00 26.67  ? 870  VAL A CA  1 
ATOM   4543 C  C   . VAL A 1 607 ? -29.756 -64.020 -5.412  1.00 27.17  ? 870  VAL A C   1 
ATOM   4544 O  O   . VAL A 1 607 ? -30.533 -63.229 -4.772  1.00 26.16  ? 870  VAL A O   1 
ATOM   4545 C  CB  . VAL A 1 607 ? -27.507 -63.179 -6.378  1.00 26.82  ? 870  VAL A CB  1 
ATOM   4546 C  CG1 . VAL A 1 607 ? -28.199 -61.885 -6.783  1.00 23.51  ? 870  VAL A CG1 1 
ATOM   4547 C  CG2 . VAL A 1 607 ? -26.033 -62.946 -6.087  1.00 27.62  ? 870  VAL A CG2 1 
ATOM   4548 N  N   . ARG A 1 608 ? -30.197 -64.964 -6.269  1.00 25.27  ? 871  ARG A N   1 
ATOM   4549 C  CA  . ARG A 1 608 ? -31.666 -65.196 -6.493  1.00 27.14  ? 871  ARG A CA  1 
ATOM   4550 C  C   . ARG A 1 608 ? -32.401 -65.412 -5.152  1.00 30.27  ? 871  ARG A C   1 
ATOM   4551 O  O   . ARG A 1 608 ? -33.494 -64.869 -4.982  1.00 31.41  ? 871  ARG A O   1 
ATOM   4552 C  CB  . ARG A 1 608 ? -31.937 -66.401 -7.403  1.00 24.99  ? 871  ARG A CB  1 
ATOM   4553 C  CG  . ARG A 1 608 ? -31.455 -66.199 -8.831  1.00 25.87  ? 871  ARG A CG  1 
ATOM   4554 C  CD  . ARG A 1 608 ? -31.701 -67.449 -9.655  1.00 27.22  ? 871  ARG A CD  1 
ATOM   4555 N  NE  . ARG A 1 608 ? -31.606 -67.163 -11.071 1.00 31.38  ? 871  ARG A NE  1 
ATOM   4556 C  CZ  . ARG A 1 608 ? -31.510 -68.105 -12.012 1.00 33.22  ? 871  ARG A CZ  1 
ATOM   4557 N  NH1 . ARG A 1 608 ? -31.522 -69.373 -11.663 1.00 38.39  ? 871  ARG A NH1 1 
ATOM   4558 N  NH2 . ARG A 1 608 ? -31.394 -67.796 -13.287 1.00 30.90  ? 871  ARG A NH2 1 
ATOM   4559 N  N   . SER A 1 609 ? -31.824 -66.151 -4.218  1.00 26.48  ? 872  SER A N   1 
ATOM   4560 C  CA  . SER A 1 609 ? -32.445 -66.371 -2.888  1.00 28.32  ? 872  SER A CA  1 
ATOM   4561 C  C   . SER A 1 609 ? -32.548 -65.079 -2.116  1.00 28.72  ? 872  SER A C   1 
ATOM   4562 O  O   . SER A 1 609 ? -33.429 -65.010 -1.271  1.00 28.78  ? 872  SER A O   1 
ATOM   4563 C  CB  . SER A 1 609 ? -31.689 -67.374 -2.051  1.00 28.19  ? 872  SER A CB  1 
ATOM   4564 O  OG  . SER A 1 609 ? -31.587 -68.587 -2.764  1.00 30.34  ? 872  SER A OG  1 
ATOM   4565 N  N   . LEU A 1 610 ? -31.627 -64.136 -2.286  1.00 29.85  ? 873  LEU A N   1 
ATOM   4566 C  CA  . LEU A 1 610 ? -31.655 -62.866 -1.494  1.00 28.11  ? 873  LEU A CA  1 
ATOM   4567 C  C   . LEU A 1 610 ? -32.766 -61.943 -2.035  1.00 30.33  ? 873  LEU A C   1 
ATOM   4568 O  O   . LEU A 1 610 ? -33.493 -61.316 -1.227  1.00 26.71  ? 873  LEU A O   1 
ATOM   4569 C  CB  . LEU A 1 610 ? -30.274 -62.209 -1.552  1.00 29.18  ? 873  LEU A CB  1 
ATOM   4570 C  CG  . LEU A 1 610 ? -29.189 -62.851 -0.683  1.00 29.83  ? 873  LEU A CG  1 
ATOM   4571 C  CD1 . LEU A 1 610 ? -27.848 -62.205 -0.950  1.00 32.17  ? 873  LEU A CD1 1 
ATOM   4572 C  CD2 . LEU A 1 610 ? -29.508 -62.778 0.790   1.00 31.33  ? 873  LEU A CD2 1 
ATOM   4573 N  N   . ILE A 1 611 ? -32.884 -61.885 -3.361  1.00 29.52  ? 874  ILE A N   1 
ATOM   4574 C  CA  . ILE A 1 611 ? -33.836 -61.021 -4.105  1.00 29.97  ? 874  ILE A CA  1 
ATOM   4575 C  C   . ILE A 1 611 ? -35.252 -61.598 -3.959  1.00 32.32  ? 874  ILE A C   1 
ATOM   4576 O  O   . ILE A 1 611 ? -36.172 -60.817 -3.679  1.00 32.68  ? 874  ILE A O   1 
ATOM   4577 C  CB  . ILE A 1 611 ? -33.422 -60.882 -5.583  1.00 28.91  ? 874  ILE A CB  1 
ATOM   4578 C  CG1 . ILE A 1 611 ? -32.104 -60.119 -5.709  1.00 30.31  ? 874  ILE A CG1 1 
ATOM   4579 C  CG2 . ILE A 1 611 ? -34.545 -60.218 -6.369  1.00 31.17  ? 874  ILE A CG2 1 
ATOM   4580 C  CD1 . ILE A 1 611 ? -31.573 -59.985 -7.107  1.00 31.71  ? 874  ILE A CD1 1 
ATOM   4581 N  N   . GLY A 1 612 ? -35.389 -62.923 -4.056  1.00 31.27  ? 875  GLY A N   1 
ATOM   4582 C  CA  . GLY A 1 612 ? -36.607 -63.679 -3.694  1.00 34.87  ? 875  GLY A CA  1 
ATOM   4583 C  C   . GLY A 1 612 ? -37.234 -64.339 -4.910  1.00 33.20  ? 875  GLY A C   1 
ATOM   4584 O  O   . GLY A 1 612 ? -36.579 -64.478 -5.950  1.00 30.34  ? 875  GLY A O   1 
ATOM   4585 N  N   . ASN A 1 613 ? -38.521 -64.620 -4.821  1.00 38.09  ? 876  ASN A N   1 
ATOM   4586 C  CA  . ASN A 1 613 ? -39.232 -65.507 -5.774  1.00 38.49  ? 876  ASN A CA  1 
ATOM   4587 C  C   . ASN A 1 613 ? -39.738 -64.630 -6.910  1.00 36.52  ? 876  ASN A C   1 
ATOM   4588 O  O   . ASN A 1 613 ? -40.837 -64.110 -6.815  1.00 43.29  ? 876  ASN A O   1 
ATOM   4589 C  CB  . ASN A 1 613 ? -40.352 -66.273 -5.063  1.00 43.95  ? 876  ASN A CB  1 
ATOM   4590 C  CG  . ASN A 1 613 ? -41.020 -67.291 -5.962  1.00 49.41  ? 876  ASN A CG  1 
ATOM   4591 O  OD1 . ASN A 1 613 ? -40.504 -67.622 -7.024  1.00 47.72  ? 876  ASN A OD1 1 
ATOM   4592 N  ND2 . ASN A 1 613 ? -42.151 -67.826 -5.517  1.00 54.29  ? 876  ASN A ND2 1 
ATOM   4593 N  N   . GLU A 1 614 ? -38.928 -64.499 -7.934  1.00 32.78  ? 877  GLU A N   1 
ATOM   4594 C  CA  . GLU A 1 614 ? -39.112 -63.593 -9.077  1.00 30.20  ? 877  GLU A CA  1 
ATOM   4595 C  C   . GLU A 1 614 ? -38.948 -64.475 -10.312 1.00 30.11  ? 877  GLU A C   1 
ATOM   4596 O  O   . GLU A 1 614 ? -38.662 -65.684 -10.151 1.00 29.75  ? 877  GLU A O   1 
ATOM   4597 C  CB  . GLU A 1 614 ? -38.077 -62.467 -9.029  1.00 33.22  ? 877  GLU A CB  1 
ATOM   4598 C  CG  . GLU A 1 614 ? -38.172 -61.542 -7.820  1.00 31.28  ? 877  GLU A CG  1 
ATOM   4599 C  CD  . GLU A 1 614 ? -39.354 -60.572 -7.827  1.00 32.61  ? 877  GLU A CD  1 
ATOM   4600 O  OE1 . GLU A 1 614 ? -39.962 -60.321 -8.897  1.00 30.11  ? 877  GLU A OE1 1 
ATOM   4601 O  OE2 . GLU A 1 614 ? -39.586 -59.971 -6.777  1.00 31.81  ? 877  GLU A OE2 1 
ATOM   4602 N  N   . GLU A 1 615 ? -39.159 -63.919 -11.492 1.00 32.03  ? 878  GLU A N   1 
ATOM   4603 C  CA  . GLU A 1 615 ? -38.930 -64.651 -12.757 1.00 34.66  ? 878  GLU A CA  1 
ATOM   4604 C  C   . GLU A 1 615 ? -37.496 -64.345 -13.198 1.00 33.69  ? 878  GLU A C   1 
ATOM   4605 O  O   . GLU A 1 615 ? -37.246 -63.173 -13.448 1.00 36.18  ? 878  GLU A O   1 
ATOM   4606 C  CB  . GLU A 1 615 ? -39.882 -64.195 -13.860 1.00 40.57  ? 878  GLU A CB  1 
ATOM   4607 C  CG  . GLU A 1 615 ? -39.589 -64.902 -15.180 1.00 47.45  ? 878  GLU A CG  1 
ATOM   4608 C  CD  . GLU A 1 615 ? -40.454 -64.402 -16.322 1.00 64.84  ? 878  GLU A CD  1 
ATOM   4609 O  OE1 . GLU A 1 615 ? -41.469 -63.710 -16.044 1.00 68.86  ? 878  GLU A OE1 1 
ATOM   4610 O  OE2 . GLU A 1 615 ? -40.111 -64.684 -17.491 1.00 80.25  ? 878  GLU A OE2 1 
ATOM   4611 N  N   . TYR A 1 616 ? -36.675 -65.387 -13.371 1.00 34.05  ? 879  TYR A N   1 
ATOM   4612 C  CA  . TYR A 1 616 ? -35.261 -65.374 -13.805 1.00 34.67  ? 879  TYR A CA  1 
ATOM   4613 C  C   . TYR A 1 616 ? -35.130 -66.168 -15.098 1.00 36.08  ? 879  TYR A C   1 
ATOM   4614 O  O   . TYR A 1 616 ? -35.901 -67.083 -15.296 1.00 33.12  ? 879  TYR A O   1 
ATOM   4615 C  CB  . TYR A 1 616 ? -34.382 -66.011 -12.735 1.00 32.17  ? 879  TYR A CB  1 
ATOM   4616 C  CG  . TYR A 1 616 ? -34.481 -65.348 -11.383 1.00 32.01  ? 879  TYR A CG  1 
ATOM   4617 C  CD1 . TYR A 1 616 ? -33.768 -64.197 -11.095 1.00 31.17  ? 879  TYR A CD1 1 
ATOM   4618 C  CD2 . TYR A 1 616 ? -35.265 -65.883 -10.384 1.00 29.93  ? 879  TYR A CD2 1 
ATOM   4619 C  CE1 . TYR A 1 616 ? -33.834 -63.604 -9.840  1.00 34.04  ? 879  TYR A CE1 1 
ATOM   4620 C  CE2 . TYR A 1 616 ? -35.359 -65.291 -9.130  1.00 30.41  ? 879  TYR A CE2 1 
ATOM   4621 C  CZ  . TYR A 1 616 ? -34.645 -64.148 -8.850  1.00 32.35  ? 879  TYR A CZ  1 
ATOM   4622 O  OH  . TYR A 1 616 ? -34.713 -63.570 -7.605  1.00 31.48  ? 879  TYR A OH  1 
ATOM   4623 N  N   . THR A 1 617 ? -34.139 -65.814 -15.919 1.00 37.32  ? 880  THR A N   1 
ATOM   4624 C  CA  . THR A 1 617 ? -33.647 -66.591 -17.084 1.00 38.10  ? 880  THR A CA  1 
ATOM   4625 C  C   . THR A 1 617 ? -32.229 -67.091 -16.781 1.00 38.66  ? 880  THR A C   1 
ATOM   4626 O  O   . THR A 1 617 ? -31.418 -66.300 -16.193 1.00 34.69  ? 880  THR A O   1 
ATOM   4627 C  CB  . THR A 1 617 ? -33.598 -65.687 -18.317 1.00 42.87  ? 880  THR A CB  1 
ATOM   4628 O  OG1 . THR A 1 617 ? -34.846 -64.995 -18.397 1.00 42.10  ? 880  THR A OG1 1 
ATOM   4629 C  CG2 . THR A 1 617 ? -33.294 -66.420 -19.606 1.00 44.41  ? 880  THR A CG2 1 
ATOM   4630 N  N   . ASP A 1 618 ? -31.908 -68.325 -17.184 1.00 36.97  ? 881  ASP A N   1 
ATOM   4631 C  CA  . ASP A 1 618 ? -30.517 -68.836 -17.162 1.00 38.17  ? 881  ASP A CA  1 
ATOM   4632 C  C   . ASP A 1 618 ? -29.822 -68.445 -18.487 1.00 36.80  ? 881  ASP A C   1 
ATOM   4633 O  O   . ASP A 1 618 ? -30.110 -69.058 -19.522 1.00 31.13  ? 881  ASP A O   1 
ATOM   4634 C  CB  . ASP A 1 618 ? -30.518 -70.334 -16.869 1.00 40.33  ? 881  ASP A CB  1 
ATOM   4635 C  CG  . ASP A 1 618 ? -29.137 -70.973 -16.819 1.00 44.43  ? 881  ASP A CG  1 
ATOM   4636 O  OD1 . ASP A 1 618 ? -28.119 -70.233 -16.626 1.00 38.85  ? 881  ASP A OD1 1 
ATOM   4637 O  OD2 . ASP A 1 618 ? -29.089 -72.212 -16.972 1.00 43.53  ? 881  ASP A OD2 1 
ATOM   4638 N  N   . TYR A 1 619 ? -28.889 -67.485 -18.459 1.00 32.98  ? 882  TYR A N   1 
ATOM   4639 C  CA  . TYR A 1 619 ? -28.084 -67.126 -19.654 1.00 33.57  ? 882  TYR A CA  1 
ATOM   4640 C  C   . TYR A 1 619 ? -26.794 -67.948 -19.748 1.00 34.50  ? 882  TYR A C   1 
ATOM   4641 O  O   . TYR A 1 619 ? -26.106 -67.797 -20.766 1.00 33.41  ? 882  TYR A O   1 
ATOM   4642 C  CB  . TYR A 1 619 ? -27.793 -65.629 -19.682 1.00 33.95  ? 882  TYR A CB  1 
ATOM   4643 C  CG  . TYR A 1 619 ? -29.010 -64.782 -19.882 1.00 37.18  ? 882  TYR A CG  1 
ATOM   4644 C  CD1 . TYR A 1 619 ? -29.616 -64.691 -21.125 1.00 37.10  ? 882  TYR A CD1 1 
ATOM   4645 C  CD2 . TYR A 1 619 ? -29.575 -64.100 -18.818 1.00 36.19  ? 882  TYR A CD2 1 
ATOM   4646 C  CE1 . TYR A 1 619 ? -30.737 -63.899 -21.319 1.00 37.06  ? 882  TYR A CE1 1 
ATOM   4647 C  CE2 . TYR A 1 619 ? -30.692 -63.303 -18.993 1.00 35.90  ? 882  TYR A CE2 1 
ATOM   4648 C  CZ  . TYR A 1 619 ? -31.259 -63.183 -20.251 1.00 33.45  ? 882  TYR A CZ  1 
ATOM   4649 O  OH  . TYR A 1 619 ? -32.367 -62.411 -20.389 1.00 32.24  ? 882  TYR A OH  1 
ATOM   4650 N  N   . MET A 1 620 ? -26.467 -68.810 -18.780 1.00 35.24  ? 883  MET A N   1 
ATOM   4651 C  CA  . MET A 1 620 ? -25.150 -69.497 -18.793 1.00 36.53  ? 883  MET A CA  1 
ATOM   4652 C  C   . MET A 1 620 ? -25.032 -70.483 -19.972 1.00 38.66  ? 883  MET A C   1 
ATOM   4653 O  O   . MET A 1 620 ? -23.954 -70.562 -20.572 1.00 43.65  ? 883  MET A O   1 
ATOM   4654 C  CB  . MET A 1 620 ? -24.812 -70.164 -17.461 1.00 33.62  ? 883  MET A CB  1 
ATOM   4655 C  CG  . MET A 1 620 ? -24.957 -69.235 -16.247 1.00 38.01  ? 883  MET A CG  1 
ATOM   4656 S  SD  . MET A 1 620 ? -24.146 -67.621 -16.416 1.00 33.60  ? 883  MET A SD  1 
ATOM   4657 C  CE  . MET A 1 620 ? -22.457 -68.168 -16.678 1.00 32.19  ? 883  MET A CE  1 
ATOM   4658 N  N   . PRO A 1 621 ? -26.083 -71.234 -20.389 1.00 41.04  ? 884  PRO A N   1 
ATOM   4659 C  CA  . PRO A 1 621 ? -26.006 -72.053 -21.614 1.00 41.21  ? 884  PRO A CA  1 
ATOM   4660 C  C   . PRO A 1 621 ? -25.667 -71.343 -22.931 1.00 42.84  ? 884  PRO A C   1 
ATOM   4661 O  O   . PRO A 1 621 ? -25.387 -72.011 -23.890 1.00 47.10  ? 884  PRO A O   1 
ATOM   4662 C  CB  . PRO A 1 621 ? -27.400 -72.732 -21.693 1.00 40.83  ? 884  PRO A CB  1 
ATOM   4663 C  CG  . PRO A 1 621 ? -27.837 -72.816 -20.210 1.00 38.59  ? 884  PRO A CG  1 
ATOM   4664 C  CD  . PRO A 1 621 ? -27.341 -71.492 -19.645 1.00 38.53  ? 884  PRO A CD  1 
ATOM   4665 N  N   . SER A 1 622 ? -25.690 -70.004 -22.937 0.50 44.27  ? 885  SER A N   1 
ATOM   4666 C  CA  . SER A 1 622 ? -25.197 -69.150 -24.052 0.50 44.67  ? 885  SER A CA  1 
ATOM   4667 C  C   . SER A 1 622 ? -23.700 -69.411 -24.282 0.50 46.73  ? 885  SER A C   1 
ATOM   4668 O  O   . SER A 1 622 ? -23.230 -69.194 -25.422 0.50 47.39  ? 885  SER A O   1 
ATOM   4669 C  CB  . SER A 1 622 ? -25.478 -67.683 -23.795 0.50 44.14  ? 885  SER A CB  1 
ATOM   4670 O  OG  . SER A 1 622 ? -24.586 -67.132 -22.835 0.50 40.33  ? 885  SER A OG  1 
ATOM   4671 N  N   . MET A 1 623 ? -22.986 -69.867 -23.245 0.50 43.89  ? 886  MET A N   1 
ATOM   4672 C  CA  . MET A 1 623 ? -21.532 -70.177 -23.310 0.50 49.00  ? 886  MET A CA  1 
ATOM   4673 C  C   . MET A 1 623 ? -21.358 -71.681 -23.550 0.50 52.12  ? 886  MET A C   1 
ATOM   4674 O  O   . MET A 1 623 ? -22.124 -72.460 -22.953 0.50 52.90  ? 886  MET A O   1 
ATOM   4675 C  CB  . MET A 1 623 ? -20.820 -69.780 -22.011 0.50 48.03  ? 886  MET A CB  1 
ATOM   4676 C  CG  . MET A 1 623 ? -21.330 -68.483 -21.413 0.50 49.78  ? 886  MET A CG  1 
ATOM   4677 S  SD  . MET A 1 623 ? -20.364 -67.926 -19.981 0.50 48.80  ? 886  MET A SD  1 
ATOM   4678 C  CE  . MET A 1 623 ? -18.884 -67.366 -20.820 0.50 48.54  ? 886  MET A CE  1 
ATOM   4679 N  N   . LYS A 1 624 ? -20.378 -72.071 -24.371 0.50 56.60  ? 887  LYS A N   1 
ATOM   4680 C  CA  . LYS A 1 624 ? -20.143 -73.484 -24.777 0.50 59.10  ? 887  LYS A CA  1 
ATOM   4681 C  C   . LYS A 1 624 ? -20.018 -74.379 -23.533 0.50 55.51  ? 887  LYS A C   1 
ATOM   4682 O  O   . LYS A 1 624 ? -20.722 -75.408 -23.477 0.50 52.47  ? 887  LYS A O   1 
ATOM   4683 C  CB  . LYS A 1 624 ? -18.896 -73.589 -25.662 0.50 63.87  ? 887  LYS A CB  1 
ATOM   4684 C  CG  . LYS A 1 624 ? -18.770 -74.891 -26.446 0.50 66.98  ? 887  LYS A CG  1 
ATOM   4685 C  CD  . LYS A 1 624 ? -17.665 -74.884 -27.490 0.50 71.44  ? 887  LYS A CD  1 
ATOM   4686 C  CE  . LYS A 1 624 ? -16.337 -75.410 -26.980 0.50 74.63  ? 887  LYS A CE  1 
ATOM   4687 N  NZ  . LYS A 1 624 ? -15.634 -74.420 -26.128 0.50 76.71  ? 887  LYS A NZ  1 
ATOM   4688 N  N   . ARG A 1 625 ? -19.168 -74.009 -22.568 0.50 52.35  ? 888  ARG A N   1 
ATOM   4689 C  CA  . ARG A 1 625 ? -18.801 -74.885 -21.418 0.50 52.43  ? 888  ARG A CA  1 
ATOM   4690 C  C   . ARG A 1 625 ? -20.031 -75.193 -20.553 0.50 51.32  ? 888  ARG A C   1 
ATOM   4691 O  O   . ARG A 1 625 ? -19.980 -76.203 -19.830 0.50 50.26  ? 888  ARG A O   1 
ATOM   4692 C  CB  . ARG A 1 625 ? -17.699 -74.249 -20.563 0.50 53.44  ? 888  ARG A CB  1 
ATOM   4693 C  CG  . ARG A 1 625 ? -18.132 -73.010 -19.789 0.50 52.86  ? 888  ARG A CG  1 
ATOM   4694 C  CD  . ARG A 1 625 ? -17.107 -72.574 -18.755 0.50 52.59  ? 888  ARG A CD  1 
ATOM   4695 N  NE  . ARG A 1 625 ? -16.993 -73.528 -17.658 0.50 52.45  ? 888  ARG A NE  1 
ATOM   4696 C  CZ  . ARG A 1 625 ? -15.947 -73.620 -16.844 0.50 52.68  ? 888  ARG A CZ  1 
ATOM   4697 N  NH1 . ARG A 1 625 ? -14.907 -72.819 -17.007 0.50 55.04  ? 888  ARG A NH1 1 
ATOM   4698 N  NH2 . ARG A 1 625 ? -15.938 -74.517 -15.876 0.50 52.56  ? 888  ARG A NH2 1 
ATOM   4699 N  N   . PHE A 1 626 ? -21.070 -74.344 -20.588 1.00 51.65  ? 889  PHE A N   1 
ATOM   4700 C  CA  . PHE A 1 626 ? -22.322 -74.534 -19.789 1.00 54.90  ? 889  PHE A CA  1 
ATOM   4701 C  C   . PHE A 1 626 ? -23.475 -75.099 -20.630 1.00 63.88  ? 889  PHE A C   1 
ATOM   4702 O  O   . PHE A 1 626 ? -24.529 -75.427 -20.053 1.00 62.68  ? 889  PHE A O   1 
ATOM   4703 C  CB  . PHE A 1 626 ? -22.789 -73.234 -19.115 1.00 49.09  ? 889  PHE A CB  1 
ATOM   4704 C  CG  . PHE A 1 626 ? -21.790 -72.668 -18.138 1.00 47.66  ? 889  PHE A CG  1 
ATOM   4705 C  CD1 . PHE A 1 626 ? -21.474 -73.350 -16.970 1.00 48.77  ? 889  PHE A CD1 1 
ATOM   4706 C  CD2 . PHE A 1 626 ? -21.111 -71.495 -18.423 1.00 44.63  ? 889  PHE A CD2 1 
ATOM   4707 C  CE1 . PHE A 1 626 ? -20.487 -72.871 -16.115 1.00 51.36  ? 889  PHE A CE1 1 
ATOM   4708 C  CE2 . PHE A 1 626 ? -20.141 -71.004 -17.563 1.00 47.74  ? 889  PHE A CE2 1 
ATOM   4709 C  CZ  . PHE A 1 626 ? -19.837 -71.687 -16.399 1.00 48.43  ? 889  PHE A CZ  1 
ATOM   4710 N  N   . ARG A 1 627 ? -23.280 -75.189 -21.951 0.50 66.57  ? 890  ARG A N   1 
ATOM   4711 C  CA  . ARG A 1 627 ? -24.321 -75.599 -22.933 0.50 76.17  ? 890  ARG A CA  1 
ATOM   4712 C  C   . ARG A 1 627 ? -24.677 -77.074 -22.700 0.50 80.27  ? 890  ARG A C   1 
ATOM   4713 O  O   . ARG A 1 627 ? -25.816 -77.466 -23.029 0.50 88.75  ? 890  ARG A O   1 
ATOM   4714 C  CB  . ARG A 1 627 ? -23.845 -75.339 -24.368 0.50 76.08  ? 890  ARG A CB  1 
ATOM   4715 C  CG  . ARG A 1 627 ? -24.878 -75.671 -25.435 0.50 74.34  ? 890  ARG A CG  1 
ATOM   4716 C  CD  . ARG A 1 627 ? -24.650 -74.941 -26.746 0.50 74.47  ? 890  ARG A CD  1 
ATOM   4717 N  NE  . ARG A 1 627 ? -23.293 -75.087 -27.253 0.50 75.88  ? 890  ARG A NE  1 
ATOM   4718 C  CZ  . ARG A 1 627 ? -22.846 -76.137 -27.937 0.50 77.92  ? 890  ARG A CZ  1 
ATOM   4719 N  NH1 . ARG A 1 627 ? -23.647 -77.157 -28.201 0.50 74.10  ? 890  ARG A NH1 1 
ATOM   4720 N  NH2 . ARG A 1 627 ? -21.592 -76.164 -28.355 0.50 79.09  ? 890  ARG A NH2 1 
ATOM   4721 N  N   . ARG A 1 628 ? -23.744 -77.850 -22.139 0.50 80.61  ? 891  ARG A N   1 
ATOM   4722 C  CA  . ARG A 1 628 ? -23.969 -79.253 -21.699 0.50 79.07  ? 891  ARG A CA  1 
ATOM   4723 C  C   . ARG A 1 628 ? -24.989 -79.922 -22.631 0.50 77.25  ? 891  ARG A C   1 
ATOM   4724 O  O   . ARG A 1 628 ? -24.942 -81.125 -22.897 0.50 70.25  ? 891  ARG A O   1 
ATOM   4725 C  CB  . ARG A 1 628 ? -24.444 -79.269 -20.242 0.50 77.95  ? 891  ARG A CB  1 
ATOM   4726 C  CG  . ARG A 1 628 ? -25.776 -78.567 -20.009 0.50 77.34  ? 891  ARG A CG  1 
ATOM   4727 C  CD  . ARG A 1 628 ? -26.955 -79.356 -20.549 0.50 76.10  ? 891  ARG A CD  1 
ATOM   4728 N  NE  . ARG A 1 628 ? -26.841 -80.775 -20.245 0.50 75.53  ? 891  ARG A NE  1 
ATOM   4729 C  CZ  . ARG A 1 628 ? -27.048 -81.302 -19.046 0.50 73.09  ? 891  ARG A CZ  1 
ATOM   4730 N  NH1 . ARG A 1 628 ? -27.373 -80.522 -18.030 0.50 74.72  ? 891  ARG A NH1 1 
ATOM   4731 N  NH2 . ARG A 1 628 ? -26.923 -82.603 -18.863 0.50 73.48  ? 891  ARG A NH2 1 
HETATM 4732 ZN ZN  . ZN  B 2 .   ? -6.522  -55.132 -23.766 1.00 25.61  2 1001 ZN  A ZN  1 
HETATM 4733 ZN ZN  . ZN  C 2 .   ? -25.895 -14.385 -13.154 1.00 56.84  2 1002 ZN  A ZN  1 
HETATM 4734 O  O1  A MES D 3 .   ? -28.402 -57.363 0.354   0.25 861.15 ? 1003 MES A O1  1 
HETATM 4735 O  O1  B MES D 3 .   ? -28.297 -57.316 0.630   0.25 32.42  ? 1003 MES A O1  1 
HETATM 4736 C  C2  A MES D 3 .   ? -27.798 -57.701 1.593   0.25 863.78 ? 1003 MES A C2  1 
HETATM 4737 C  C2  B MES D 3 .   ? -27.506 -57.909 1.651   0.25 31.29  ? 1003 MES A C2  1 
HETATM 4738 C  C3  A MES D 3 .   ? -26.351 -57.280 1.630   0.25 864.36 ? 1003 MES A C3  1 
HETATM 4739 C  C3  B MES D 3 .   ? -26.026 -57.766 1.377   0.25 31.06  ? 1003 MES A C3  1 
HETATM 4740 N  N4  A MES D 3 .   ? -25.596 -57.925 0.512   0.25 863.84 ? 1003 MES A N4  1 
HETATM 4741 N  N4  B MES D 3 .   ? -25.713 -58.402 0.063   0.25 30.10  ? 1003 MES A N4  1 
HETATM 4742 C  C5  A MES D 3 .   ? -26.284 -57.632 -0.783  0.25 860.20 ? 1003 MES A C5  1 
HETATM 4743 C  C5  B MES D 3 .   ? -26.510 -57.694 -0.980  0.25 31.39  ? 1003 MES A C5  1 
HETATM 4744 C  C6  A MES D 3 .   ? -27.736 -58.034 -0.704  0.25 858.01 ? 1003 MES A C6  1 
HETATM 4745 C  C6  B MES D 3 .   ? -27.980 -57.830 -0.660  0.25 31.65  ? 1003 MES A C6  1 
HETATM 4746 C  C7  A MES D 3 .   ? -24.162 -57.481 0.489   0.25 864.74 ? 1003 MES A C7  1 
HETATM 4747 C  C7  B MES D 3 .   ? -24.245 -58.455 -0.276  0.25 30.02  ? 1003 MES A C7  1 
HETATM 4748 C  C8  A MES D 3 .   ? -23.241 -58.470 -0.197  0.25 863.85 ? 1003 MES A C8  1 
HETATM 4749 C  C8  B MES D 3 .   ? -23.338 -57.599 0.596   0.25 28.39  ? 1003 MES A C8  1 
HETATM 4750 S  S   A MES D 3 .   ? -21.526 -58.027 -0.024  0.25 863.55 ? 1003 MES A S   1 
HETATM 4751 S  S   B MES D 3 .   ? -21.612 -58.051 0.430   0.25 27.20  ? 1003 MES A S   1 
HETATM 4752 O  O1S A MES D 3 .   ? -20.999 -58.820 1.032   0.25 863.00 ? 1003 MES A O1S 1 
HETATM 4753 O  O1S B MES D 3 .   ? -21.547 -59.458 0.696   0.25 27.45  ? 1003 MES A O1S 1 
HETATM 4754 O  O2S A MES D 3 .   ? -20.918 -58.329 -1.303  0.25 847.90 ? 1003 MES A O2S 1 
HETATM 4755 O  O2S B MES D 3 .   ? -21.245 -57.758 -0.933  0.25 25.48  ? 1003 MES A O2S 1 
HETATM 4756 O  O3S A MES D 3 .   ? -21.507 -56.616 0.257   0.25 863.51 ? 1003 MES A O3S 1 
HETATM 4757 O  O3S B MES D 3 .   ? -20.901 -57.272 1.394   0.25 25.20  ? 1003 MES A O3S 1 
HETATM 4758 S  S   . DMS E 4 .   ? -26.952 -61.859 -20.991 1.00 45.93  ? 1004 DMS A S   1 
HETATM 4759 O  O   . DMS E 4 .   ? -26.854 -62.488 -22.389 1.00 49.00  ? 1004 DMS A O   1 
HETATM 4760 C  C1  . DMS E 4 .   ? -28.168 -60.588 -21.117 1.00 43.06  ? 1004 DMS A C1  1 
HETATM 4761 C  C2  . DMS E 4 .   ? -25.497 -60.819 -20.969 1.00 46.22  ? 1004 DMS A C2  1 
HETATM 4762 S  S   . DMS F 4 .   ? -15.994 -69.273 -28.936 1.00 98.15  ? 1005 DMS A S   1 
HETATM 4763 O  O   . DMS F 4 .   ? -16.401 -67.851 -29.167 1.00 81.43  ? 1005 DMS A O   1 
HETATM 4764 C  C1  . DMS F 4 .   ? -17.032 -69.888 -27.622 1.00 85.76  ? 1005 DMS A C1  1 
HETATM 4765 C  C2  . DMS F 4 .   ? -14.446 -69.227 -28.064 1.00 93.34  ? 1005 DMS A C2  1 
HETATM 4766 S  S   . DMS G 4 .   ? -23.091 -47.972 -16.210 1.00 58.70  ? 1006 DMS A S   1 
HETATM 4767 O  O   . DMS G 4 .   ? -24.216 -47.588 -17.132 1.00 55.48  ? 1006 DMS A O   1 
HETATM 4768 C  C1  . DMS G 4 .   ? -21.744 -46.986 -16.793 1.00 56.21  ? 1006 DMS A C1  1 
HETATM 4769 C  C2  . DMS G 4 .   ? -22.480 -49.465 -16.873 1.00 51.03  ? 1006 DMS A C2  1 
HETATM 4770 P  P   . PO4 H 5 .   ? -3.985  -39.167 -23.867 1.00 67.62  ? 1007 PO4 A P   1 
HETATM 4771 O  O1  . PO4 H 5 .   ? -2.607  -39.923 -23.341 1.00 44.42  ? 1007 PO4 A O1  1 
HETATM 4772 O  O2  . PO4 H 5 .   ? -3.660  -37.850 -24.737 1.00 35.44  ? 1007 PO4 A O2  1 
HETATM 4773 O  O3  . PO4 H 5 .   ? -4.876  -40.166 -24.708 1.00 44.23  ? 1007 PO4 A O3  1 
HETATM 4774 O  O4  . PO4 H 5 .   ? -4.740  -38.708 -22.648 1.00 54.01  ? 1007 PO4 A O4  1 
HETATM 4775 P  P   . PO4 I 5 .   ? -18.357 -9.468  -29.526 1.00 120.28 ? 1008 PO4 A P   1 
HETATM 4776 O  O1  . PO4 I 5 .   ? -17.695 -9.853  -28.155 1.00 71.04  ? 1008 PO4 A O1  1 
HETATM 4777 O  O2  . PO4 I 5 .   ? -17.289 -9.254  -30.611 1.00 92.57  ? 1008 PO4 A O2  1 
HETATM 4778 O  O3  . PO4 I 5 .   ? -19.320 -10.591 -29.994 1.00 91.08  ? 1008 PO4 A O3  1 
HETATM 4779 O  O4  . PO4 I 5 .   ? -19.140 -8.156  -29.349 1.00 98.60  ? 1008 PO4 A O4  1 
HETATM 4780 C  C1  . PEG J 6 .   ? -16.413 -43.580 -41.128 1.00 62.99  ? 1009 PEG A C1  1 
HETATM 4781 O  O1  . PEG J 6 .   ? -17.808 -43.458 -40.884 1.00 61.50  ? 1009 PEG A O1  1 
HETATM 4782 C  C2  . PEG J 6 .   ? -16.122 -44.110 -42.496 1.00 66.32  ? 1009 PEG A C2  1 
HETATM 4783 O  O2  . PEG J 6 .   ? -16.302 -45.527 -42.522 1.00 68.59  ? 1009 PEG A O2  1 
HETATM 4784 C  C3  . PEG J 6 .   ? -16.217 -46.076 -43.834 1.00 75.97  ? 1009 PEG A C3  1 
HETATM 4785 C  C4  . PEG J 6 .   ? -15.093 -47.058 -43.918 1.00 84.32  ? 1009 PEG A C4  1 
HETATM 4786 O  O4  . PEG J 6 .   ? -15.545 -48.356 -44.269 1.00 85.76  ? 1009 PEG A O4  1 
HETATM 4787 N  N1  . O3D K 7 .   ? -21.592 -28.383 -0.799  0.35 54.90  ? 1010 O3D A N1  1 
HETATM 4788 C  C4  . O3D K 7 .   ? -19.838 -26.647 -0.448  0.35 51.15  ? 1010 O3D A C4  1 
HETATM 4789 C  C5  . O3D K 7 .   ? -18.571 -26.487 -0.843  0.35 51.67  ? 1010 O3D A C5  1 
HETATM 4790 C  C6  . O3D K 7 .   ? -18.432 -25.132 -1.234  0.35 51.16  ? 1010 O3D A C6  1 
HETATM 4791 C  C7  . O3D K 7 .   ? -19.613 -24.563 -1.057  0.35 51.81  ? 1010 O3D A C7  1 
HETATM 4792 C  C8  . O3D K 7 .   ? -22.815 -27.594 -0.811  0.35 54.12  ? 1010 O3D A C8  1 
HETATM 4793 C  C1  . O3D K 7 .   ? -21.967 -29.300 -3.083  0.35 55.20  ? 1010 O3D A C1  1 
HETATM 4794 C  C2  . O3D K 7 .   ? -21.106 -28.441 -2.166  0.35 54.69  ? 1010 O3D A C2  1 
HETATM 4795 C  C3  . O3D K 7 .   ? -20.602 -27.797 0.100   0.35 52.79  ? 1010 O3D A C3  1 
HETATM 4796 C  C9  . O3D K 7 .   ? -23.996 -28.273 -1.491  0.35 54.06  ? 1010 O3D A C9  1 
HETATM 4797 O  O1  . O3D K 7 .   ? -23.623 -27.477 -3.948  0.35 55.19  ? 1010 O3D A O1  1 
HETATM 4798 O  O2  . O3D K 7 .   ? -24.493 -29.749 -3.584  0.35 52.43  ? 1010 O3D A O2  1 
HETATM 4799 O  O3  . O3D K 7 .   ? -20.512 -25.468 -0.572  0.35 51.86  ? 1010 O3D A O3  1 
HETATM 4800 S  S1  . O3D K 7 .   ? -23.621 -28.684 -3.167  0.35 53.32  ? 1010 O3D A S1  1 
HETATM 4801 CL CL  . CL  L 8 .   ? 4.269   -48.734 -29.814 0.42 17.92  ? 1011 CL  A CL  1 
HETATM 4802 O  O   . HOH M 9 .   ? -33.596 -47.399 -4.447  1.00 36.83  ? 1101 HOH A O   1 
HETATM 4803 O  O   . HOH M 9 .   ? -7.712  -48.837 0.489   1.00 50.08  ? 1102 HOH A O   1 
HETATM 4804 O  O   . HOH M 9 .   ? -5.287  -58.288 -29.828 1.00 35.39  ? 1103 HOH A O   1 
HETATM 4805 O  O   . HOH M 9 .   ? -6.181  -12.270 -22.295 1.00 56.86  ? 1104 HOH A O   1 
HETATM 4806 O  O   . HOH M 9 .   ? 1.183   -21.173 -45.268 1.00 51.58  ? 1105 HOH A O   1 
HETATM 4807 O  O   . HOH M 9 .   ? -32.813 -51.971 -27.156 1.00 43.26  ? 1106 HOH A O   1 
HETATM 4808 O  O   . HOH M 9 .   ? -28.599 -69.798 -14.086 1.00 48.41  ? 1107 HOH A O   1 
HETATM 4809 O  O   . HOH M 9 .   ? -35.737 -56.910 -29.797 1.00 62.54  ? 1108 HOH A O   1 
HETATM 4810 O  O   . HOH M 9 .   ? -3.046  -48.798 -39.940 1.00 55.03  ? 1109 HOH A O   1 
HETATM 4811 O  O   . HOH M 9 .   ? -13.673 -12.905 -40.369 1.00 54.85  ? 1110 HOH A O   1 
HETATM 4812 O  O   . HOH M 9 .   ? -17.228 -34.578 -42.089 1.00 58.86  ? 1111 HOH A O   1 
HETATM 4813 O  O   . HOH M 9 .   ? -29.390 -55.945 -36.582 1.00 59.18  ? 1112 HOH A O   1 
HETATM 4814 O  O   . HOH M 9 .   ? -4.356  -53.402 -28.094 1.00 32.20  ? 1113 HOH A O   1 
HETATM 4815 O  O   . HOH M 9 .   ? -14.796 -17.023 -36.546 1.00 49.99  ? 1114 HOH A O   1 
HETATM 4816 O  O   . HOH M 9 .   ? 1.591   -40.515 -24.407 0.35 42.77  ? 1115 HOH A O   1 
HETATM 4817 O  O   . HOH M 9 .   ? -16.422 -11.923 -29.515 1.00 53.84  ? 1116 HOH A O   1 
HETATM 4818 O  O   . HOH M 9 .   ? 4.637   -16.286 -21.841 1.00 54.37  ? 1117 HOH A O   1 
HETATM 4819 O  O   . HOH M 9 .   ? -22.603 -53.253 -46.861 1.00 56.17  ? 1118 HOH A O   1 
HETATM 4820 O  O   . HOH M 9 .   ? -23.576 -46.132 -36.904 1.00 54.83  ? 1119 HOH A O   1 
HETATM 4821 O  O   . HOH M 9 .   ? 10.411  -38.631 -29.794 1.00 53.89  ? 1120 HOH A O   1 
HETATM 4822 O  O   . HOH M 9 .   ? -19.867 -65.979 -37.725 1.00 55.07  ? 1121 HOH A O   1 
HETATM 4823 O  O   . HOH M 9 .   ? -7.858  -42.865 -42.840 1.00 58.13  ? 1122 HOH A O   1 
HETATM 4824 O  O   . HOH M 9 .   ? -15.550 -21.841 -18.924 1.00 40.26  ? 1123 HOH A O   1 
HETATM 4825 O  O   . HOH M 9 .   ? -5.509  -59.995 -0.882  1.00 37.85  ? 1124 HOH A O   1 
HETATM 4826 O  O   . HOH M 9 .   ? 0.095   -32.651 -27.918 1.00 28.84  ? 1125 HOH A O   1 
HETATM 4827 O  O   . HOH M 9 .   ? 5.887   -44.731 -35.823 1.00 48.10  ? 1126 HOH A O   1 
HETATM 4828 O  O   . HOH M 9 .   ? 3.065   -51.328 -26.574 0.42 33.99  ? 1127 HOH A O   1 
HETATM 4829 O  O   . HOH M 9 .   ? -6.900  -60.613 -30.525 1.00 57.29  ? 1128 HOH A O   1 
HETATM 4830 O  O   . HOH M 9 .   ? -32.486 -60.286 -18.969 1.00 45.50  ? 1129 HOH A O   1 
HETATM 4831 O  O   . HOH M 9 .   ? -11.419 -47.113 -43.251 1.00 52.21  ? 1130 HOH A O   1 
HETATM 4832 O  O   . HOH M 9 .   ? -32.437 -70.693 -9.155  1.00 53.88  ? 1131 HOH A O   1 
HETATM 4833 O  O   . HOH M 9 .   ? -38.919 -60.758 -4.429  1.00 33.94  ? 1132 HOH A O   1 
HETATM 4834 O  O   . HOH M 9 .   ? -24.390 -69.204 -27.711 1.00 46.45  ? 1133 HOH A O   1 
HETATM 4835 O  O   . HOH M 9 .   ? -21.902 -31.227 -39.779 1.00 43.57  ? 1134 HOH A O   1 
HETATM 4836 O  O   . HOH M 9 .   ? -8.768  -63.652 -30.733 1.00 49.99  ? 1135 HOH A O   1 
HETATM 4837 O  O   . HOH M 9 .   ? -19.563 -9.640  -33.406 1.00 60.63  ? 1136 HOH A O   1 
HETATM 4838 O  O   . HOH M 9 .   ? -31.843 -57.149 -21.724 1.00 30.58  ? 1137 HOH A O   1 
HETATM 4839 O  O   . HOH M 9 .   ? 11.312  -34.437 -33.124 1.00 43.69  ? 1138 HOH A O   1 
HETATM 4840 O  O   . HOH M 9 .   ? -40.246 -61.178 -11.319 1.00 31.70  ? 1139 HOH A O   1 
HETATM 4841 O  O   . HOH M 9 .   ? -0.516  -10.858 -29.754 1.00 50.09  ? 1140 HOH A O   1 
HETATM 4842 O  O   . HOH M 9 .   ? -6.986  -20.094 -26.911 1.00 38.79  ? 1141 HOH A O   1 
HETATM 4843 O  O   . HOH M 9 .   ? -38.188 -67.600 -8.200  1.00 38.82  ? 1142 HOH A O   1 
HETATM 4844 O  O   . HOH M 9 .   ? -9.386  -21.154 -27.342 1.00 36.86  ? 1143 HOH A O   1 
HETATM 4845 O  O   . HOH M 9 .   ? -15.188 -54.204 -39.692 1.00 44.21  ? 1144 HOH A O   1 
HETATM 4846 O  O   . HOH M 9 .   ? -29.812 -50.229 -27.339 1.00 42.24  ? 1145 HOH A O   1 
HETATM 4847 O  O   . HOH M 9 .   ? -21.664 -65.909 -4.652  1.00 41.17  ? 1146 HOH A O   1 
HETATM 4848 O  O   . HOH M 9 .   ? -40.632 -57.610 -6.385  1.00 58.76  ? 1147 HOH A O   1 
HETATM 4849 O  O   . HOH M 9 .   ? -7.368  -47.084 -18.211 1.00 33.45  ? 1148 HOH A O   1 
HETATM 4850 O  O   . HOH M 9 .   ? -21.043 -46.801 -9.837  1.00 56.79  ? 1149 HOH A O   1 
HETATM 4851 O  O   . HOH M 9 .   ? -4.457  -54.051 -11.763 1.00 46.93  ? 1150 HOH A O   1 
HETATM 4852 O  O   . HOH M 9 .   ? -12.392 -58.033 0.000   0.50 27.54  ? 1151 HOH A O   1 
HETATM 4853 O  O   . HOH M 9 .   ? -3.895  -15.187 -20.564 1.00 53.02  ? 1152 HOH A O   1 
HETATM 4854 O  O   . HOH M 9 .   ? -10.890 -48.008 -39.079 1.00 29.40  ? 1153 HOH A O   1 
HETATM 4855 O  O   . HOH M 9 .   ? -24.674 -13.780 -4.710  1.00 52.13  ? 1154 HOH A O   1 
HETATM 4856 O  O   . HOH M 9 .   ? -4.016  -57.352 -9.839  1.00 33.31  ? 1155 HOH A O   1 
HETATM 4857 O  O   . HOH M 9 .   ? 1.597   -32.176 -38.880 1.00 30.46  ? 1156 HOH A O   1 
HETATM 4858 O  O   . HOH M 9 .   ? 3.968   -37.466 -44.092 1.00 58.11  ? 1157 HOH A O   1 
HETATM 4859 O  O   . HOH M 9 .   ? 0.111   -64.604 -19.138 1.00 35.37  ? 1158 HOH A O   1 
HETATM 4860 O  O   . HOH M 9 .   ? -35.583 -66.444 -0.736  1.00 43.14  ? 1159 HOH A O   1 
HETATM 4861 O  O   . HOH M 9 .   ? -9.120  -58.826 -13.246 1.00 22.32  ? 1160 HOH A O   1 
HETATM 4862 O  O   . HOH M 9 .   ? -13.418 -12.664 -27.685 1.00 55.24  ? 1161 HOH A O   1 
HETATM 4863 O  O   . HOH M 9 .   ? -22.599 -65.707 -23.844 1.00 38.30  ? 1162 HOH A O   1 
HETATM 4864 O  O   . HOH M 9 .   ? -13.749 -74.279 -14.137 1.00 41.07  ? 1163 HOH A O   1 
HETATM 4865 O  O   . HOH M 9 .   ? -14.391 -44.648 -3.925  1.00 62.78  ? 1164 HOH A O   1 
HETATM 4866 O  O   . HOH M 9 .   ? -24.333 -68.576 -38.485 1.00 53.50  ? 1165 HOH A O   1 
HETATM 4867 O  O   . HOH M 9 .   ? -34.750 -62.739 0.635   1.00 26.53  ? 1166 HOH A O   1 
HETATM 4868 O  O   . HOH M 9 .   ? -19.631 -43.422 -38.068 1.00 62.12  ? 1167 HOH A O   1 
HETATM 4869 O  O   . HOH M 9 .   ? 6.101   -31.119 -19.271 1.00 39.46  ? 1168 HOH A O   1 
HETATM 4870 O  O   . HOH M 9 .   ? -28.377 -67.772 -30.145 1.00 57.05  ? 1169 HOH A O   1 
HETATM 4871 O  O   . HOH M 9 .   ? -26.597 -34.576 -25.603 0.35 30.65  ? 1170 HOH A O   1 
HETATM 4872 O  O   . HOH M 9 .   ? -28.869 -62.669 -25.411 1.00 33.14  ? 1171 HOH A O   1 
HETATM 4873 O  O   . HOH M 9 .   ? -32.835 -63.236 -15.277 1.00 30.52  ? 1172 HOH A O   1 
HETATM 4874 O  O   . HOH M 9 .   ? -32.828 -48.796 -18.853 1.00 49.78  ? 1173 HOH A O   1 
HETATM 4875 O  O   . HOH M 9 .   ? 4.034   -28.686 -44.281 1.00 44.22  ? 1174 HOH A O   1 
HETATM 4876 O  O   . HOH M 9 .   ? -27.260 -56.842 -40.019 1.00 51.68  ? 1175 HOH A O   1 
HETATM 4877 O  O   . HOH M 9 .   ? 1.306   -19.439 -20.141 1.00 64.02  ? 1176 HOH A O   1 
HETATM 4878 O  O   . HOH M 9 .   ? -8.386  -64.705 -6.901  1.00 40.20  ? 1177 HOH A O   1 
HETATM 4879 O  O   . HOH M 9 .   ? -8.841  -26.244 -44.543 1.00 43.05  ? 1178 HOH A O   1 
HETATM 4880 O  O   . HOH M 9 .   ? -20.147 -75.884 -14.249 1.00 60.02  ? 1179 HOH A O   1 
HETATM 4881 O  O   . HOH M 9 .   ? -42.452 -62.715 -5.194  1.00 44.67  ? 1180 HOH A O   1 
HETATM 4882 O  O   . HOH M 9 .   ? -14.893 -68.056 -19.496 0.50 23.19  ? 1181 HOH A O   1 
HETATM 4883 O  O   . HOH M 9 .   ? -14.938 -34.700 -29.019 1.00 26.40  ? 1182 HOH A O   1 
HETATM 4884 O  O   . HOH M 9 .   ? 2.761   -39.182 -27.000 1.00 32.14  ? 1183 HOH A O   1 
HETATM 4885 O  O   . HOH M 9 .   ? -26.675 -25.539 -33.421 1.00 31.03  ? 1184 HOH A O   1 
HETATM 4886 O  O   . HOH M 9 .   ? -20.744 -19.296 -38.946 1.00 53.51  ? 1185 HOH A O   1 
HETATM 4887 O  O   . HOH M 9 .   ? 0.008   -31.067 -23.107 1.00 29.71  ? 1186 HOH A O   1 
HETATM 4888 O  O   . HOH M 9 .   ? 7.465   -49.409 -30.365 1.00 55.21  ? 1187 HOH A O   1 
HETATM 4889 O  O   . HOH M 9 .   ? -5.251  -48.594 -28.836 1.00 31.54  ? 1188 HOH A O   1 
HETATM 4890 O  O   . HOH M 9 .   ? -4.440  -65.291 -15.214 1.00 37.92  ? 1189 HOH A O   1 
HETATM 4891 O  O   . HOH M 9 .   ? -36.919 -50.130 -5.333  1.00 37.28  ? 1190 HOH A O   1 
HETATM 4892 O  O   . HOH M 9 .   ? -4.985  -15.192 -28.079 1.00 43.54  ? 1191 HOH A O   1 
HETATM 4893 O  O   . HOH M 9 .   ? -12.278 -36.762 -39.632 1.00 30.04  ? 1192 HOH A O   1 
HETATM 4894 O  O   . HOH M 9 .   ? -18.056 -61.946 -2.958  1.00 25.08  ? 1193 HOH A O   1 
HETATM 4895 O  O   . HOH M 9 .   ? -29.671 -33.462 -28.704 1.00 57.18  ? 1194 HOH A O   1 
HETATM 4896 O  O   . HOH M 9 .   ? -1.230  -41.318 -21.470 1.00 56.41  ? 1195 HOH A O   1 
HETATM 4897 O  O   . HOH M 9 .   ? -17.896 -65.598 -36.299 1.00 46.18  ? 1196 HOH A O   1 
HETATM 4898 O  O   . HOH M 9 .   ? -24.512 -70.084 -34.144 1.00 57.47  ? 1197 HOH A O   1 
HETATM 4899 O  O   . HOH M 9 .   ? -20.678 -63.963 -43.351 1.00 52.54  ? 1198 HOH A O   1 
HETATM 4900 O  O   . HOH M 9 .   ? -19.592 -27.207 -39.914 1.00 33.96  ? 1199 HOH A O   1 
HETATM 4901 O  O   . HOH M 9 .   ? -38.842 -57.033 -20.592 1.00 39.07  ? 1200 HOH A O   1 
HETATM 4902 O  O   . HOH M 9 .   ? 2.481   -44.208 -41.362 1.00 50.36  ? 1201 HOH A O   1 
HETATM 4903 O  O   . HOH M 9 .   ? -20.636 -29.037 -25.012 1.00 44.93  ? 1202 HOH A O   1 
HETATM 4904 O  O   . HOH M 9 .   ? -28.786 -45.604 2.527   1.00 49.41  ? 1203 HOH A O   1 
HETATM 4905 O  O   . HOH M 9 .   ? -23.177 -20.905 -38.081 1.00 42.42  ? 1204 HOH A O   1 
HETATM 4906 O  O   . HOH M 9 .   ? -28.411 -66.330 -0.295  1.00 33.59  ? 1205 HOH A O   1 
HETATM 4907 O  O   . HOH M 9 .   ? -42.422 -61.437 -14.891 1.00 44.67  ? 1206 HOH A O   1 
HETATM 4908 O  O   . HOH M 9 .   ? -2.644  -57.762 -27.288 1.00 29.48  ? 1207 HOH A O   1 
HETATM 4909 O  O   . HOH M 9 .   ? -23.200 -64.923 -38.837 1.00 42.64  ? 1208 HOH A O   1 
HETATM 4910 O  O   . HOH M 9 .   ? -14.624 -70.583 -18.544 0.50 30.38  ? 1209 HOH A O   1 
HETATM 4911 O  O   . HOH M 9 .   ? -20.828 -31.435 -29.420 1.00 34.67  ? 1210 HOH A O   1 
HETATM 4912 O  O   . HOH M 9 .   ? -35.069 -50.006 -12.758 1.00 47.98  ? 1211 HOH A O   1 
HETATM 4913 O  O   . HOH M 9 .   ? -23.450 -24.243 1.380   0.35 45.40  ? 1212 HOH A O   1 
HETATM 4914 O  O   . HOH M 9 .   ? -10.955 -62.206 -18.867 1.00 21.35  ? 1213 HOH A O   1 
HETATM 4915 O  O   . HOH M 9 .   ? -22.019 -9.728  -9.189  1.00 56.27  ? 1214 HOH A O   1 
HETATM 4916 O  O   . HOH M 9 .   ? -26.481 -71.245 -3.636  1.00 45.55  ? 1215 HOH A O   1 
HETATM 4917 O  O   . HOH M 9 .   ? -38.787 -54.808 -18.963 1.00 40.78  ? 1216 HOH A O   1 
HETATM 4918 O  O   . HOH M 9 .   ? -22.496 -50.927 -9.129  1.00 31.45  ? 1217 HOH A O   1 
HETATM 4919 O  O   . HOH M 9 .   ? -13.228 -68.397 -6.214  1.00 44.39  ? 1218 HOH A O   1 
HETATM 4920 O  O   . HOH M 9 .   ? -17.422 -31.499 -42.046 1.00 53.60  ? 1219 HOH A O   1 
HETATM 4921 O  O   . HOH M 9 .   ? -3.380  -19.888 -23.585 1.00 42.44  ? 1220 HOH A O   1 
HETATM 4922 O  O   . HOH M 9 .   ? -39.451 -55.319 -6.322  1.00 44.11  ? 1221 HOH A O   1 
HETATM 4923 O  O   . HOH M 9 .   ? -26.548 -30.589 -23.358 1.00 48.86  ? 1222 HOH A O   1 
HETATM 4924 O  O   . HOH M 9 .   ? -12.861 -42.502 -39.003 1.00 39.83  ? 1223 HOH A O   1 
HETATM 4925 O  O   . HOH M 9 .   ? -29.518 -50.502 -29.977 1.00 52.73  ? 1224 HOH A O   1 
HETATM 4926 O  O   . HOH M 9 .   ? -27.919 -46.859 0.120   1.00 49.32  ? 1225 HOH A O   1 
HETATM 4927 O  O   . HOH M 9 .   ? -3.108  -55.039 -18.034 1.00 29.74  ? 1226 HOH A O   1 
HETATM 4928 O  O   . HOH M 9 .   ? -8.487  -17.036 -39.242 1.00 44.18  ? 1227 HOH A O   1 
HETATM 4929 O  O   . HOH M 9 .   ? -14.667 -63.876 -0.462  1.00 26.65  ? 1228 HOH A O   1 
HETATM 4930 O  O   . HOH M 9 .   ? -27.215 -65.256 -40.120 1.00 46.05  ? 1229 HOH A O   1 
HETATM 4931 O  O   . HOH M 9 .   ? -30.262 -56.731 -34.395 1.00 45.57  ? 1230 HOH A O   1 
HETATM 4932 O  O   . HOH M 9 .   ? -16.503 -32.148 -18.056 1.00 47.58  ? 1231 HOH A O   1 
HETATM 4933 O  O   . HOH M 9 .   ? -3.808  -61.347 -15.366 1.00 36.45  ? 1232 HOH A O   1 
HETATM 4934 O  O   . HOH M 9 .   ? -40.151 -24.034 -26.379 1.00 54.42  ? 1233 HOH A O   1 
HETATM 4935 O  O   . HOH M 9 .   ? -22.262 -74.233 -11.592 1.00 31.18  ? 1234 HOH A O   1 
HETATM 4936 O  O   . HOH M 9 .   ? -31.096 -73.548 -18.315 1.00 60.78  ? 1235 HOH A O   1 
HETATM 4937 O  O   . HOH M 9 .   ? -28.279 -48.977 -31.790 1.00 46.08  ? 1236 HOH A O   1 
HETATM 4938 O  O   . HOH M 9 .   ? -19.418 -17.056 -11.249 1.00 48.53  ? 1237 HOH A O   1 
HETATM 4939 O  O   . HOH M 9 .   ? 6.608   -35.309 -44.028 1.00 52.76  ? 1238 HOH A O   1 
HETATM 4940 O  O   . HOH M 9 .   ? -30.120 -60.662 -23.190 1.00 32.87  ? 1239 HOH A O   1 
HETATM 4941 O  O   . HOH M 9 .   ? -19.047 -45.019 -9.126  1.00 58.86  ? 1240 HOH A O   1 
HETATM 4942 O  O   . HOH M 9 .   ? -20.714 -66.069 -1.251  1.00 44.05  ? 1241 HOH A O   1 
HETATM 4943 O  O   . HOH M 9 .   ? 5.478   -29.896 -21.696 1.00 31.57  ? 1242 HOH A O   1 
HETATM 4944 O  O   . HOH M 9 .   ? -31.803 -59.936 -15.890 1.00 30.98  ? 1243 HOH A O   1 
HETATM 4945 O  O   . HOH M 9 .   ? -18.879 -65.064 -7.295  1.00 23.99  ? 1244 HOH A O   1 
HETATM 4946 O  O   . HOH M 9 .   ? -4.181  -22.868 -25.186 1.00 32.69  ? 1245 HOH A O   1 
HETATM 4947 O  O   . HOH M 9 .   ? -38.337 -60.712 -14.440 1.00 34.42  ? 1246 HOH A O   1 
HETATM 4948 O  O   . HOH M 9 .   ? -41.212 -58.033 -9.915  0.50 29.69  ? 1247 HOH A O   1 
HETATM 4949 O  O   . HOH M 9 .   ? 5.797   -32.589 -37.648 1.00 40.36  ? 1248 HOH A O   1 
HETATM 4950 O  O   . HOH M 9 .   ? -19.262 -20.454 -40.745 1.00 44.28  ? 1249 HOH A O   1 
HETATM 4951 O  O   . HOH M 9 .   ? -20.263 -70.726 -6.095  1.00 44.11  ? 1250 HOH A O   1 
HETATM 4952 O  O   . HOH M 9 .   ? 4.181   -26.496 -29.424 1.00 37.25  ? 1251 HOH A O   1 
HETATM 4953 O  O   . HOH M 9 .   ? -13.788 -49.479 -31.553 0.50 22.03  ? 1252 HOH A O   1 
HETATM 4954 O  O   . HOH M 9 .   ? -27.474 -52.249 -41.947 1.00 53.25  ? 1253 HOH A O   1 
HETATM 4955 O  O   . HOH M 9 .   ? -28.157 -18.121 -35.117 1.00 42.13  ? 1254 HOH A O   1 
HETATM 4956 O  O   . HOH M 9 .   ? 9.156   -23.876 -36.437 1.00 53.92  ? 1255 HOH A O   1 
HETATM 4957 O  O   . HOH M 9 .   ? -36.285 -58.113 -20.735 1.00 42.85  ? 1256 HOH A O   1 
HETATM 4958 O  O   . HOH M 9 .   ? -27.299 -15.359 -20.138 1.00 46.89  ? 1257 HOH A O   1 
HETATM 4959 O  O   . HOH M 9 .   ? -18.366 -75.841 -16.523 1.00 61.08  ? 1258 HOH A O   1 
HETATM 4960 O  O   . HOH M 9 .   ? -14.214 -45.951 2.930   1.00 61.58  ? 1259 HOH A O   1 
HETATM 4961 O  O   . HOH M 9 .   ? -19.082 -69.552 -8.261  1.00 24.89  ? 1260 HOH A O   1 
HETATM 4962 O  O   . HOH M 9 .   ? -27.955 -16.730 -32.403 1.00 38.62  ? 1261 HOH A O   1 
HETATM 4963 O  O   . HOH M 9 .   ? -17.379 -29.403 -41.155 1.00 57.23  ? 1262 HOH A O   1 
HETATM 4964 O  O   . HOH M 9 .   ? -20.537 -67.162 -25.448 1.00 30.44  ? 1263 HOH A O   1 
HETATM 4965 O  O   . HOH M 9 .   ? -29.871 -59.375 -19.833 1.00 30.34  ? 1264 HOH A O   1 
HETATM 4966 O  O   . HOH M 9 .   ? -22.693 -27.404 -18.981 1.00 42.92  ? 1265 HOH A O   1 
HETATM 4967 O  O   . HOH M 9 .   ? -21.377 -49.158 -35.112 1.00 43.11  ? 1266 HOH A O   1 
HETATM 4968 O  O   . HOH M 9 .   ? -27.916 -22.867 -26.582 1.00 33.28  ? 1267 HOH A O   1 
HETATM 4969 O  O   . HOH M 9 .   ? -20.068 -37.855 -36.761 1.00 32.45  ? 1268 HOH A O   1 
HETATM 4970 O  O   . HOH M 9 .   ? -25.051 -53.304 -1.926  1.00 29.84  ? 1269 HOH A O   1 
HETATM 4971 O  O   . HOH M 9 .   ? -23.016 -75.190 -9.063  1.00 36.77  ? 1270 HOH A O   1 
HETATM 4972 O  O   . HOH M 9 .   ? -15.441 -65.724 -33.989 1.00 50.64  ? 1271 HOH A O   1 
HETATM 4973 O  O   . HOH M 9 .   ? -21.349 -41.208 -35.586 1.00 48.58  ? 1272 HOH A O   1 
HETATM 4974 O  O   . HOH M 9 .   ? -13.015 -53.364 -40.914 1.00 52.12  ? 1273 HOH A O   1 
HETATM 4975 O  O   . HOH M 9 .   ? 8.201   -45.292 -29.357 0.42 39.87  ? 1274 HOH A O   1 
HETATM 4976 O  O   . HOH M 9 .   ? -23.100 -27.420 -24.675 1.00 41.08  ? 1275 HOH A O   1 
HETATM 4977 O  O   . HOH M 9 .   ? -13.685 -53.503 -1.591  1.00 28.56  ? 1276 HOH A O   1 
HETATM 4978 O  O   . HOH M 9 .   ? 7.817   -42.990 -36.268 1.00 47.11  ? 1277 HOH A O   1 
HETATM 4979 O  O   . HOH M 9 .   ? -19.029 -68.287 -1.715  1.00 45.81  ? 1278 HOH A O   1 
HETATM 4980 O  O   . HOH M 9 .   ? -8.996  -70.801 -14.620 1.00 38.19  ? 1279 HOH A O   1 
HETATM 4981 O  O   . HOH M 9 .   ? -5.598  -59.013 -12.197 1.00 38.91  ? 1280 HOH A O   1 
HETATM 4982 O  O   . HOH M 9 .   ? -23.538 -45.162 -8.968  1.00 49.08  ? 1281 HOH A O   1 
HETATM 4983 O  O   . HOH M 9 .   ? -4.991  -34.067 -20.750 1.00 48.02  ? 1282 HOH A O   1 
HETATM 4984 O  O   . HOH M 9 .   ? -14.277 -56.314 -1.540  1.00 20.77  ? 1283 HOH A O   1 
HETATM 4985 O  O   . HOH M 9 .   ? 10.113  -25.553 -32.477 1.00 58.16  ? 1284 HOH A O   1 
HETATM 4986 O  O   . HOH M 9 .   ? -23.050 -33.690 -36.881 1.00 32.37  ? 1285 HOH A O   1 
HETATM 4987 O  O   . HOH M 9 .   ? -15.688 -54.680 -43.853 1.00 51.16  ? 1286 HOH A O   1 
HETATM 4988 O  O   . HOH M 9 .   ? -5.956  -58.344 -37.138 1.00 53.08  ? 1287 HOH A O   1 
HETATM 4989 O  O   . HOH M 9 .   ? -7.588  -51.324 -10.185 1.00 51.66  ? 1288 HOH A O   1 
HETATM 4990 O  O   . HOH M 9 .   ? -0.357  -35.587 -28.150 1.00 35.13  ? 1289 HOH A O   1 
HETATM 4991 O  O   . HOH M 9 .   ? 4.943   -36.761 -23.453 1.00 48.90  ? 1290 HOH A O   1 
HETATM 4992 O  O   . HOH M 9 .   ? 10.484  -26.580 -29.277 1.00 42.14  ? 1291 HOH A O   1 
HETATM 4993 O  O   . HOH M 9 .   ? -35.858 -54.059 -3.317  1.00 33.08  ? 1292 HOH A O   1 
HETATM 4994 O  O   . HOH M 9 .   ? -7.442  -72.293 -18.395 1.00 61.76  ? 1293 HOH A O   1 
HETATM 4995 O  O   . HOH M 9 .   ? 10.592  -29.484 -34.335 1.00 47.01  ? 1294 HOH A O   1 
HETATM 4996 O  O   . HOH M 9 .   ? 6.083   -19.787 -43.330 1.00 55.87  ? 1295 HOH A O   1 
HETATM 4997 O  O   . HOH M 9 .   ? -6.120  -32.763 -16.669 0.35 42.99  ? 1296 HOH A O   1 
HETATM 4998 O  O   . HOH M 9 .   ? -14.199 -52.160 -5.824  1.00 25.50  ? 1297 HOH A O   1 
HETATM 4999 O  O   . HOH M 9 .   ? -17.030 -51.757 -15.581 1.00 21.48  ? 1298 HOH A O   1 
HETATM 5000 O  O   . HOH M 9 .   ? -21.187 -64.923 -41.065 1.00 44.20  ? 1299 HOH A O   1 
HETATM 5001 O  O   . HOH M 9 .   ? -2.462  -39.660 -45.780 1.00 47.65  ? 1300 HOH A O   1 
HETATM 5002 O  O   . HOH M 9 .   ? 7.746   -21.927 -24.315 1.00 46.11  ? 1301 HOH A O   1 
HETATM 5003 O  O   . HOH M 9 .   ? -29.569 -63.308 -33.851 1.00 62.06  ? 1302 HOH A O   1 
HETATM 5004 O  O   . HOH M 9 .   ? -9.699  -63.948 -32.929 1.00 48.86  ? 1303 HOH A O   1 
HETATM 5005 O  O   . HOH M 9 .   ? -35.460 -58.136 -27.547 1.00 51.82  ? 1304 HOH A O   1 
HETATM 5006 O  O   . HOH M 9 .   ? 1.043   -38.440 -21.546 1.00 50.13  ? 1305 HOH A O   1 
HETATM 5007 O  O   . HOH M 9 .   ? -19.057 -37.678 -25.265 1.00 75.99  ? 1306 HOH A O   1 
HETATM 5008 O  O   . HOH M 9 .   ? -13.878 -51.011 -43.477 1.00 55.10  ? 1307 HOH A O   1 
HETATM 5009 O  O   . HOH M 9 .   ? 2.777   -64.363 -20.824 1.00 23.73  ? 1308 HOH A O   1 
HETATM 5010 O  O   . HOH M 9 .   ? 6.187   -40.412 -19.845 0.35 32.28  ? 1309 HOH A O   1 
HETATM 5011 O  O   . HOH M 9 .   ? -4.938  -56.381 -31.695 1.00 28.01  ? 1310 HOH A O   1 
HETATM 5012 O  O   . HOH M 9 .   ? -4.595  -62.299 -4.676  1.00 39.48  ? 1311 HOH A O   1 
HETATM 5013 O  O   . HOH M 9 .   ? -5.752  -50.177 -18.923 1.00 28.01  ? 1312 HOH A O   1 
HETATM 5014 O  O   . HOH M 9 .   ? -11.703 -10.994 -34.393 1.00 58.70  ? 1313 HOH A O   1 
HETATM 5015 O  O   . HOH M 9 .   ? -34.048 -69.926 -18.494 1.00 38.42  ? 1314 HOH A O   1 
HETATM 5016 O  O   . HOH M 9 .   ? -0.083  -47.939 -36.208 1.00 42.39  ? 1315 HOH A O   1 
HETATM 5017 O  O   . HOH M 9 .   ? 6.386   -29.474 -44.009 1.00 50.94  ? 1316 HOH A O   1 
HETATM 5018 O  O   . HOH M 9 .   ? -31.160 -71.581 -13.641 1.00 53.04  ? 1317 HOH A O   1 
HETATM 5019 O  O   . HOH M 9 .   ? 9.890   -38.067 -39.239 1.00 46.14  ? 1318 HOH A O   1 
HETATM 5020 O  O   . HOH M 9 .   ? -12.604 -37.410 -22.508 1.00 51.82  ? 1319 HOH A O   1 
HETATM 5021 O  O   . HOH M 9 .   ? -24.203 -57.778 -46.743 1.00 48.04  ? 1320 HOH A O   1 
HETATM 5022 O  O   . HOH M 9 .   ? 10.707  -40.801 -38.416 1.00 58.51  ? 1321 HOH A O   1 
HETATM 5023 O  O   . HOH M 9 .   ? -11.551 -40.921 -20.029 1.00 55.81  ? 1322 HOH A O   1 
HETATM 5024 O  O   . HOH M 9 .   ? -37.486 -52.337 -12.850 1.00 27.18  ? 1323 HOH A O   1 
HETATM 5025 O  O   . HOH M 9 .   ? -37.659 -68.151 -12.692 1.00 47.16  ? 1324 HOH A O   1 
HETATM 5026 O  O   . HOH M 9 .   ? -7.685  -29.925 -46.190 1.00 48.23  ? 1325 HOH A O   1 
HETATM 5027 O  O   . HOH M 9 .   ? -39.710 -63.967 -2.129  1.00 45.96  ? 1326 HOH A O   1 
HETATM 5028 O  O   . HOH M 9 .   ? -17.583 -41.530 -37.262 1.00 45.17  ? 1327 HOH A O   1 
HETATM 5029 O  O   . HOH M 9 .   ? -17.574 -71.460 -22.841 1.00 45.16  ? 1328 HOH A O   1 
HETATM 5030 O  O   . HOH M 9 .   ? -14.825 -54.042 -3.991  1.00 27.22  ? 1329 HOH A O   1 
HETATM 5031 O  O   . HOH M 9 .   ? -4.084  -52.701 -38.424 1.00 60.74  ? 1330 HOH A O   1 
HETATM 5032 O  O   . HOH M 9 .   ? -35.262 -59.007 -0.386  1.00 49.02  ? 1331 HOH A O   1 
HETATM 5033 O  O   . HOH M 9 .   ? -23.381 -49.294 -42.176 1.00 41.92  ? 1332 HOH A O   1 
HETATM 5034 O  O   . HOH M 9 .   ? -20.214 -46.065 -25.284 1.00 38.62  ? 1333 HOH A O   1 
HETATM 5035 O  O   . HOH M 9 .   ? 0.489   -70.628 -21.495 1.00 41.39  ? 1334 HOH A O   1 
HETATM 5036 O  O   . HOH M 9 .   ? -26.230 -20.372 -39.130 1.00 65.31  ? 1335 HOH A O   1 
HETATM 5037 O  O   . HOH M 9 .   ? -33.805 -56.994 -19.827 1.00 46.33  ? 1336 HOH A O   1 
HETATM 5038 O  O   . HOH M 9 .   ? -6.310  -42.793 -21.000 1.00 42.80  ? 1337 HOH A O   1 
HETATM 5039 O  O   . HOH M 9 .   ? -18.855 -49.622 -34.754 1.00 59.98  ? 1338 HOH A O   1 
HETATM 5040 O  O   . HOH M 9 .   ? -8.519  -30.733 -15.314 1.00 47.56  ? 1339 HOH A O   1 
HETATM 5041 O  O   . HOH M 9 .   ? -4.106  -57.055 -13.523 1.00 44.38  ? 1340 HOH A O   1 
HETATM 5042 O  O   . HOH M 9 .   ? -30.165 -61.083 -32.770 1.00 54.62  ? 1341 HOH A O   1 
HETATM 5043 O  O   . HOH M 9 .   ? -25.251 -23.356 -42.081 1.00 58.85  ? 1342 HOH A O   1 
HETATM 5044 O  O   . HOH M 9 .   ? -5.877  -68.358 -27.435 1.00 34.72  ? 1343 HOH A O   1 
HETATM 5045 O  O   . HOH M 9 .   ? -9.013  -37.128 -19.459 1.00 49.62  ? 1344 HOH A O   1 
HETATM 5046 O  O   . HOH M 9 .   ? -20.908 -75.376 -5.731  1.00 58.91  ? 1345 HOH A O   1 
HETATM 5047 O  O   . HOH M 9 .   ? -12.430 -66.890 -29.717 1.00 34.59  ? 1346 HOH A O   1 
HETATM 5048 O  O   . HOH M 9 .   ? -7.137  -49.436 -6.514  1.00 48.84  ? 1347 HOH A O   1 
HETATM 5049 O  O   . HOH M 9 .   ? -3.836  -56.448 -7.162  1.00 32.42  ? 1348 HOH A O   1 
HETATM 5050 O  O   . HOH M 9 .   ? -5.825  -48.944 -21.101 1.00 28.09  ? 1349 HOH A O   1 
HETATM 5051 O  O   . HOH M 9 .   ? -30.448 -47.237 -25.037 1.00 75.36  ? 1350 HOH A O   1 
HETATM 5052 O  O   . HOH M 9 .   ? -27.261 -26.688 -35.670 1.00 37.02  ? 1351 HOH A O   1 
HETATM 5053 O  O   . HOH M 9 .   ? -31.132 -44.972 -15.607 1.00 48.03  ? 1352 HOH A O   1 
HETATM 5054 O  O   . HOH M 9 .   ? -3.800  -70.687 -9.003  1.00 37.36  ? 1353 HOH A O   1 
HETATM 5055 O  O   . HOH M 9 .   ? -7.137  -57.420 -1.078  1.00 52.21  ? 1354 HOH A O   1 
HETATM 5056 O  O   . HOH M 9 .   ? -38.141 -37.762 -26.349 1.00 60.62  ? 1355 HOH A O   1 
HETATM 5057 O  O   . HOH M 9 .   ? -34.785 -59.469 -29.397 1.00 56.00  ? 1356 HOH A O   1 
HETATM 5058 O  O   . HOH M 9 .   ? -0.298  -55.413 -33.157 1.00 59.33  ? 1357 HOH A O   1 
HETATM 5059 O  O   . HOH M 9 .   ? -11.752 -71.743 -15.596 1.00 24.86  ? 1358 HOH A O   1 
HETATM 5060 O  O   . HOH M 9 .   ? -10.684 -26.052 -12.195 0.35 28.33  ? 1359 HOH A O   1 
HETATM 5061 O  O   . HOH M 9 .   ? -2.198  -70.339 -18.413 1.00 47.49  ? 1360 HOH A O   1 
HETATM 5062 O  O   . HOH M 9 .   ? -26.693 -51.060 -1.815  1.00 40.30  ? 1361 HOH A O   1 
HETATM 5063 O  O   . HOH M 9 .   ? -13.638 -11.224 -32.281 1.00 55.23  ? 1362 HOH A O   1 
HETATM 5064 O  O   . HOH M 9 .   ? -9.539  -70.231 -22.377 1.00 55.86  ? 1363 HOH A O   1 
HETATM 5065 O  O   . HOH M 9 .   ? -33.869 -46.837 -15.665 1.00 52.39  ? 1364 HOH A O   1 
HETATM 5066 O  O   . HOH M 9 .   ? -32.185 -18.774 -31.035 1.00 55.69  ? 1365 HOH A O   1 
HETATM 5067 O  O   . HOH M 9 .   ? -12.643 -75.168 -26.738 1.00 60.15  ? 1366 HOH A O   1 
HETATM 5068 O  O   . HOH M 9 .   ? 3.567   -31.421 -37.182 1.00 29.52  ? 1367 HOH A O   1 
HETATM 5069 O  O   . HOH M 9 .   ? -6.438  -36.830 -20.728 1.00 52.63  ? 1368 HOH A O   1 
HETATM 5070 O  O   . HOH M 9 .   ? -18.268 -69.306 -24.946 1.00 39.60  ? 1369 HOH A O   1 
HETATM 5071 O  O   . HOH M 9 .   ? 13.540  -30.175 -19.692 1.00 54.46  ? 1370 HOH A O   1 
HETATM 5072 O  O   . HOH M 9 .   ? -15.131 -48.331 -18.499 1.00 37.06  ? 1371 HOH A O   1 
HETATM 5073 O  O   . HOH M 9 .   ? -3.008  -33.854 -13.567 0.35 39.85  ? 1372 HOH A O   1 
HETATM 5074 O  O   . HOH M 9 .   ? -13.365 -44.891 -10.037 0.50 36.34  ? 1373 HOH A O   1 
HETATM 5075 O  O   . HOH M 9 .   ? -17.244 -57.315 -43.789 1.00 34.38  ? 1374 HOH A O   1 
HETATM 5076 O  O   . HOH M 9 .   ? -9.549  -54.681 -41.655 1.00 52.28  ? 1375 HOH A O   1 
HETATM 5077 O  O   . HOH M 9 .   ? -8.727  -27.430 -46.523 1.00 50.30  ? 1376 HOH A O   1 
HETATM 5078 O  O   . HOH M 9 .   ? 8.513   -40.708 -31.600 1.00 52.22  ? 1377 HOH A O   1 
HETATM 5079 O  O   . HOH M 9 .   ? -0.928  -32.264 -25.545 1.00 28.71  ? 1378 HOH A O   1 
HETATM 5080 O  O   . HOH M 9 .   ? -11.579 -70.160 -23.590 1.00 59.24  ? 1379 HOH A O   1 
HETATM 5081 O  O   . HOH M 9 .   ? -15.942 -9.209  -33.503 1.00 48.57  ? 1380 HOH A O   1 
HETATM 5082 O  O   . HOH M 9 .   ? -26.406 -27.459 -42.679 1.00 51.37  ? 1381 HOH A O   1 
HETATM 5083 O  O   . HOH M 9 .   ? 3.629   -33.477 -14.391 1.00 52.64  ? 1382 HOH A O   1 
HETATM 5084 O  O   . HOH M 9 .   ? -37.597 -54.777 -24.830 1.00 62.82  ? 1383 HOH A O   1 
HETATM 5085 O  O   . HOH M 9 .   ? -3.026  -57.879 -24.523 1.00 22.34  ? 1384 HOH A O   1 
HETATM 5086 O  O   . HOH M 9 .   ? -35.720 -50.619 -22.677 1.00 54.25  ? 1385 HOH A O   1 
HETATM 5087 O  O   . HOH M 9 .   ? -14.892 -56.747 -41.965 1.00 30.24  ? 1386 HOH A O   1 
HETATM 5088 O  O   . HOH M 9 .   ? -10.028 -75.387 -9.090  1.00 66.23  ? 1387 HOH A O   1 
HETATM 5089 O  O   . HOH M 9 .   ? -19.363 -64.572 -2.857  1.00 41.02  ? 1388 HOH A O   1 
HETATM 5090 O  O   . HOH M 9 .   ? 0.019   -45.798 -42.771 1.00 50.26  ? 1389 HOH A O   1 
HETATM 5091 O  O   . HOH M 9 .   ? -11.427 -39.620 -39.665 1.00 51.76  ? 1390 HOH A O   1 
HETATM 5092 O  O   . HOH M 9 .   ? -9.024  -35.244 -44.910 1.00 53.43  ? 1391 HOH A O   1 
HETATM 5093 O  O   . HOH M 9 .   ? -20.224 -31.221 -26.753 1.00 29.83  ? 1392 HOH A O   1 
HETATM 5094 O  O   . HOH M 9 .   ? -11.015 -46.222 4.002   1.00 47.43  ? 1393 HOH A O   1 
HETATM 5095 O  O   . HOH M 9 .   ? -12.259 -43.750 -16.449 1.00 49.08  ? 1394 HOH A O   1 
HETATM 5096 O  O   . HOH M 9 .   ? -6.926  -61.379 -33.569 0.50 39.82  ? 1395 HOH A O   1 
HETATM 5097 O  O   . HOH M 9 .   ? -26.718 -67.651 -27.896 1.00 24.73  ? 1396 HOH A O   1 
HETATM 5098 O  O   . HOH M 9 .   ? -23.318 -47.908 -33.972 1.00 50.58  ? 1397 HOH A O   1 
HETATM 5099 O  O   . HOH M 9 .   ? -13.064 -32.633 -20.510 1.00 35.77  ? 1398 HOH A O   1 
HETATM 5100 O  O   . HOH M 9 .   ? -23.043 -36.948 -32.800 1.00 51.69  ? 1399 HOH A O   1 
HETATM 5101 O  O   . HOH M 9 .   ? 6.559   -39.406 -23.323 0.35 53.78  ? 1400 HOH A O   1 
HETATM 5102 O  O   . HOH M 9 .   ? -17.896 -46.938 -14.858 1.00 43.92  ? 1401 HOH A O   1 
HETATM 5103 O  O   . HOH M 9 .   ? -36.358 -60.786 -20.528 1.00 60.55  ? 1402 HOH A O   1 
HETATM 5104 O  O   . HOH M 9 .   ? 8.770   -43.448 -32.399 1.00 67.67  ? 1403 HOH A O   1 
HETATM 5105 O  O   . HOH M 9 .   ? 11.386  -37.130 -18.788 1.00 50.35  ? 1404 HOH A O   1 
HETATM 5106 O  O   . HOH M 9 .   ? 4.437   -62.288 -20.061 1.00 22.66  ? 1405 HOH A O   1 
HETATM 5107 O  O   . HOH M 9 .   ? -35.208 -67.739 -5.709  1.00 57.51  ? 1406 HOH A O   1 
HETATM 5108 O  O   . HOH M 9 .   ? 3.217   -51.349 -36.126 1.00 60.16  ? 1407 HOH A O   1 
HETATM 5109 O  O   . HOH M 9 .   ? -32.038 -13.158 -9.411  1.00 58.90  ? 1408 HOH A O   1 
HETATM 5110 O  O   . HOH M 9 .   ? -28.935 -68.875 -22.826 1.00 68.44  ? 1409 HOH A O   1 
HETATM 5111 O  O   . HOH M 9 .   ? 4.157   -40.417 -23.914 0.35 33.49  ? 1410 HOH A O   1 
HETATM 5112 O  O   . HOH M 9 .   ? -16.263 -48.996 -16.235 1.00 23.86  ? 1411 HOH A O   1 
HETATM 5113 O  O   . HOH M 9 .   ? 0.650   -31.316 -47.187 1.00 55.14  ? 1412 HOH A O   1 
HETATM 5114 O  O   . HOH M 9 .   ? -27.166 -73.542 -4.961  1.00 43.23  ? 1413 HOH A O   1 
HETATM 5115 O  O   . HOH M 9 .   ? 4.821   -68.903 -21.658 1.00 35.96  ? 1414 HOH A O   1 
HETATM 5116 O  O   . HOH M 9 .   ? -5.837  -74.370 -12.650 1.00 66.39  ? 1415 HOH A O   1 
HETATM 5117 O  O   . HOH M 9 .   ? -7.165  -29.525 -13.214 1.00 57.44  ? 1416 HOH A O   1 
HETATM 5118 O  O   . HOH M 9 .   ? -5.744  -68.726 -6.834  0.50 22.85  ? 1417 HOH A O   1 
HETATM 5119 O  O   . HOH M 9 .   ? -25.580 -75.738 -8.726  1.00 65.35  ? 1418 HOH A O   1 
HETATM 5120 O  O   . HOH M 9 .   ? 0.429   -45.152 -36.752 1.00 48.45  ? 1419 HOH A O   1 
HETATM 5121 O  O   . HOH M 9 .   ? -2.935  -55.539 -28.999 1.00 31.31  ? 1420 HOH A O   1 
HETATM 5122 O  O   . HOH M 9 .   ? -15.868 -27.297 -46.113 1.00 49.46  ? 1421 HOH A O   1 
HETATM 5123 O  O   . HOH M 9 .   ? -40.581 -62.108 -3.369  1.00 62.35  ? 1422 HOH A O   1 
HETATM 5124 O  O   . HOH M 9 .   ? -9.461  -61.949 -42.299 1.00 70.63  ? 1423 HOH A O   1 
HETATM 5125 O  O   . HOH M 9 .   ? -38.632 -28.009 -27.009 1.00 57.25  ? 1424 HOH A O   1 
HETATM 5126 O  O   . HOH M 9 .   ? 8.475   -47.921 -28.725 1.00 56.45  ? 1425 HOH A O   1 
HETATM 5127 O  O   . HOH M 9 .   ? -10.010 -38.438 -43.747 1.00 63.67  ? 1426 HOH A O   1 
HETATM 5128 O  O   . HOH M 9 .   ? -1.699  -64.913 -16.250 1.00 67.15  ? 1427 HOH A O   1 
HETATM 5129 O  O   . HOH M 9 .   ? -30.010 -33.698 -32.841 1.00 60.32  ? 1428 HOH A O   1 
HETATM 5130 O  O   . HOH M 9 .   ? -16.810 -39.244 -26.164 1.00 62.64  ? 1429 HOH A O   1 
HETATM 5131 O  O   . HOH M 9 .   ? -15.578 -41.516 -38.696 1.00 39.40  ? 1430 HOH A O   1 
HETATM 5132 O  O   . HOH M 9 .   ? -5.028  -34.485 -15.283 0.35 36.96  ? 1431 HOH A O   1 
HETATM 5133 O  O   . HOH M 9 .   ? -4.573  -49.197 2.646   1.00 68.78  ? 1432 HOH A O   1 
HETATM 5134 O  O   . HOH M 9 .   ? -13.051 -21.905 15.303  1.00 60.43  ? 1433 HOH A O   1 
HETATM 5135 O  O   . HOH M 9 .   ? -7.587  -75.580 -11.525 1.00 69.24  ? 1434 HOH A O   1 
HETATM 5136 O  O   . HOH M 9 .   ? -34.770 -49.224 -21.130 1.00 58.48  ? 1435 HOH A O   1 
HETATM 5137 O  O   . HOH M 9 .   ? -34.089 -49.289 -10.372 1.00 42.52  ? 1436 HOH A O   1 
HETATM 5138 O  O   . HOH M 9 .   ? -10.531 -68.173 -38.579 1.00 65.26  ? 1437 HOH A O   1 
HETATM 5139 O  O   . HOH M 9 .   ? -5.182  -65.129 -30.598 1.00 64.60  ? 1438 HOH A O   1 
HETATM 5140 O  O   . HOH M 9 .   ? 5.613   -44.906 -25.863 1.00 45.11  ? 1439 HOH A O   1 
HETATM 5141 O  O   . HOH M 9 .   ? 16.738  -34.527 -26.390 1.00 60.95  ? 1440 HOH A O   1 
HETATM 5142 O  O   . HOH M 9 .   ? -17.868 -28.016 -44.719 1.00 52.36  ? 1441 HOH A O   1 
HETATM 5143 O  O   . HOH M 9 .   ? 0.000   -58.033 -16.117 0.50 53.87  ? 1442 HOH A O   1 
HETATM 5144 O  O   . HOH M 9 .   ? -30.931 -24.828 -3.630  1.00 77.93  ? 1443 HOH A O   1 
HETATM 5145 O  O   . HOH M 9 .   ? -36.947 -64.709 0.156   1.00 42.55  ? 1444 HOH A O   1 
HETATM 5146 O  O   . HOH M 9 .   ? -34.640 -70.003 -9.496  1.00 58.98  ? 1445 HOH A O   1 
HETATM 5147 O  O   . HOH M 9 .   ? -42.529 -66.546 -10.125 1.00 55.19  ? 1446 HOH A O   1 
HETATM 5148 O  O   . HOH M 9 .   ? -38.042 -52.002 -4.123  1.00 46.76  ? 1447 HOH A O   1 
HETATM 5149 O  O   . HOH M 9 .   ? -41.075 -23.978 -18.055 1.00 62.28  ? 1448 HOH A O   1 
HETATM 5150 O  O   . HOH M 9 .   ? -34.937 -70.412 -13.208 1.00 59.66  ? 1449 HOH A O   1 
HETATM 5151 O  O   . HOH M 9 .   ? -30.785 -16.723 -32.454 1.00 49.78  ? 1450 HOH A O   1 
HETATM 5152 O  O   . HOH M 9 .   ? -18.983 -39.683 -38.669 1.00 48.12  ? 1451 HOH A O   1 
HETATM 5153 O  O   . HOH M 9 .   ? -15.565 -45.545 -19.375 1.00 50.55  ? 1452 HOH A O   1 
HETATM 5154 O  O   . HOH M 9 .   ? -9.431  -23.618 -3.550  1.00 55.79  ? 1453 HOH A O   1 
HETATM 5155 O  O   . HOH M 9 .   ? -22.760 -37.566 -37.288 1.00 56.86  ? 1454 HOH A O   1 
HETATM 5156 O  O   . HOH M 9 .   ? -15.842 -68.995 -5.950  1.00 31.71  ? 1455 HOH A O   1 
HETATM 5157 O  O   . HOH M 9 .   ? -36.511 -67.851 -3.666  1.00 47.05  ? 1456 HOH A O   1 
HETATM 5158 O  O   . HOH M 9 .   ? -18.868 -13.757 -38.950 1.00 74.67  ? 1457 HOH A O   1 
HETATM 5159 O  O   . HOH M 9 .   ? -36.589 -56.354 -4.438  1.00 49.39  ? 1458 HOH A O   1 
HETATM 5160 O  O   . HOH M 9 .   ? -16.695 -39.143 -39.685 1.00 54.17  ? 1459 HOH A O   1 
HETATM 5161 O  O   . HOH M 9 .   ? -24.965 -28.255 -22.471 1.00 46.12  ? 1460 HOH A O   1 
HETATM 5162 O  O   . HOH M 9 .   ? -15.397 -45.044 -9.958  0.50 43.01  ? 1461 HOH A O   1 
HETATM 5163 O  O   . HOH M 9 .   ? -41.262 -56.494 -13.733 1.00 36.11  ? 1462 HOH A O   1 
HETATM 5164 O  O   . HOH M 9 .   ? -1.196  -62.682 -15.203 1.00 51.84  ? 1463 HOH A O   1 
HETATM 5165 O  O   . HOH M 9 .   ? -14.353 -76.171 -19.385 1.00 59.48  ? 1464 HOH A O   1 
HETATM 5166 O  O   . HOH M 9 .   ? 0.380   -62.285 -17.681 1.00 45.47  ? 1465 HOH A O   1 
HETATM 5167 O  O   . HOH M 9 .   ? -21.639 -43.885 -42.342 1.00 67.36  ? 1466 HOH A O   1 
HETATM 5168 O  O   . HOH M 9 .   ? -23.456 -75.041 -14.024 1.00 61.13  ? 1467 HOH A O   1 
HETATM 5169 O  O   . HOH M 9 .   ? 0.000   -58.033 -28.901 0.50 29.05  ? 1468 HOH A O   1 
HETATM 5170 O  O   . HOH M 9 .   ? -35.638 -47.717 -14.238 1.00 55.27  ? 1469 HOH A O   1 
HETATM 5171 O  O   . HOH M 9 .   ? -2.584  -56.101 -34.130 1.00 58.02  ? 1470 HOH A O   1 
HETATM 5172 O  O   . HOH M 9 .   ? -3.104  -60.206 -6.273  1.00 56.28  ? 1471 HOH A O   1 
HETATM 5173 O  O   . HOH M 9 .   ? -18.262 -67.799 -6.394  1.00 23.17  ? 1472 HOH A O   1 
HETATM 5174 O  O   . HOH M 9 .   ? -1.266  -54.709 -1.320  1.00 46.24  ? 1473 HOH A O   1 
HETATM 5175 O  O   . HOH M 9 .   ? -12.211 -36.241 -42.561 1.00 47.06  ? 1474 HOH A O   1 
HETATM 5176 O  O   . HOH M 9 .   ? -32.007 -66.895 -23.011 1.00 60.41  ? 1475 HOH A O   1 
HETATM 5177 O  O   . HOH M 9 .   ? -19.539 -45.666 -18.996 1.00 64.08  ? 1476 HOH A O   1 
HETATM 5178 O  O   . HOH M 9 .   ? -2.780  -59.329 -0.607  1.00 49.49  ? 1477 HOH A O   1 
HETATM 5179 O  O   . HOH M 9 .   ? -25.330 -1.872  -28.619 1.00 63.57  ? 1478 HOH A O   1 
HETATM 5180 O  O   . HOH M 9 .   ? -31.774 -18.014 -5.930  1.00 68.65  ? 1479 HOH A O   1 
HETATM 5181 O  O   . HOH M 9 .   ? -32.468 -75.401 -7.346  1.00 78.83  ? 1480 HOH A O   1 
HETATM 5182 O  O   . HOH M 9 .   ? -19.970 -68.071 -4.300  1.00 33.28  ? 1481 HOH A O   1 
HETATM 5183 O  O   . HOH M 9 .   ? 0.887   -42.676 -21.960 1.00 61.15  ? 1482 HOH A O   1 
HETATM 5184 O  O   . HOH M 9 .   ? -5.461  -63.989 -6.610  1.00 52.06  ? 1483 HOH A O   1 
HETATM 5185 O  O   . HOH M 9 .   ? -16.208 -42.840 -24.409 1.00 55.13  ? 1484 HOH A O   1 
HETATM 5186 O  O   . HOH M 9 .   ? -28.336 -64.640 -42.777 1.00 61.41  ? 1485 HOH A O   1 
HETATM 5187 O  O   . HOH M 9 .   ? -4.190  -60.476 -10.222 1.00 50.55  ? 1486 HOH A O   1 
HETATM 5188 O  O   . HOH M 9 .   ? -1.634  -59.043 -3.358  1.00 54.05  ? 1487 HOH A O   1 
HETATM 5189 O  O   . HOH M 9 .   ? -44.447 -67.755 -15.599 1.00 59.36  ? 1488 HOH A O   1 
HETATM 5190 O  O   . HOH M 9 .   ? -25.448 -43.129 -33.602 1.00 65.21  ? 1489 HOH A O   1 
HETATM 5191 O  O   . HOH M 9 .   ? -28.220 -55.553 -45.347 1.00 59.30  ? 1490 HOH A O   1 
HETATM 5192 O  O   . HOH M 9 .   ? 13.147  -25.702 -27.120 1.00 48.46  ? 1491 HOH A O   1 
HETATM 5193 O  O   . HOH M 9 .   ? -43.133 -60.898 -1.729  1.00 57.70  ? 1492 HOH A O   1 
HETATM 5194 O  O   . HOH M 9 .   ? -4.225  -62.488 -8.958  1.00 52.13  ? 1493 HOH A O   1 
# 
