data_7I2H
# 
_entry.id   7I2H 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   7I2H         pdb_00007i2h 10.2210/pdb7i2h/pdb 
WWPDB D_1001408232 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-02 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.entry_id                        7I2H 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.recvd_initial_deposition_date   2025-03-06 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.SG_entry                        ? 
_pdbx_database_status.pdb_format_compatible           Y 
_pdbx_database_status.methods_development_category    ? 
# 
_pdbx_contact_author.id                 1 
_pdbx_contact_author.email              fr193@cabm.rutgers.edu 
_pdbx_contact_author.name_first         'Francesc Xavier' 
_pdbx_contact_author.name_last          Ruiz 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0457-0030 
_pdbx_contact_author.name_mi            ? 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Aschenbrenner, J.C.' 1  ? 
'Saini, M.'           2  ? 
'Chopra, A.'          3  ? 
'Marples, P.G.'       4  ? 
'Balcomb, B.H.'       5  ? 
'Lithgo, R.M.'        6  ? 
'Fearon, D.'          7  ? 
'von Delft, F.'       8  ? 
'Ruiz, F.X.'          9  ? 
'Arnold, E.'          10 ? 
# 
_citation.id                        primary 
_citation.title                     
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_volume            ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.year                      ? 
_citation.journal_id_ASTM           ? 
_citation.country                   ? 
_citation.journal_id_ISSN           ? 
_citation.journal_id_CSD            0353 
_citation.book_publisher            ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_DOI      ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.identifier_ORCID 
_citation_author.ordinal 
primary 'Aschenbrenner, J.C.' ? 1  
primary 'Saini, M.'           ? 2  
primary 'Chopra, A.'          ? 3  
primary 'Marples, P.G.'       ? 4  
primary 'Balcomb, B.H.'       ? 5  
primary 'Lithgo, R.M.'        ? 6  
primary 'Fearon, D.'          ? 7  
primary 'von Delft, F.'       ? 8  
primary 'Ruiz, F.X.'          ? 9  
primary 'Arnold, E.'          ? 10 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'NS5 RNA-dependent RNA polymerase'          73890.008 1   ? ? ? ? 
2 non-polymer syn 'ZINC ION'                                  65.409    2   ? ? ? ? 
3 non-polymer syn '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'      195.237   1   ? ? ? ? 
4 non-polymer syn 'DIMETHYL SULFOXIDE'                        78.133    3   ? ? ? ? 
5 non-polymer syn 'PHOSPHATE ION'                             94.971    2   ? ? ? ? 
6 non-polymer syn 'DI(HYDROXYETHYL)ETHER'                     106.120   1   ? ? ? ? 
7 non-polymer syn '(2M)-2-(2-methoxyphenyl)-1,3,4-oxadiazole' 176.172   2   ? ? ? ? 
8 non-polymer syn 'CHLORIDE ION'                              35.453    1   ? ? ? ? 
9 water       nat water                                       18.015    306 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION'                                  ZN  
3 '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'      MES 
4 'DIMETHYL SULFOXIDE'                        DMS 
5 'PHOSPHATE ION'                             PO4 
6 'DI(HYDROXYETHYL)ETHER'                     PEG 
7 '(2M)-2-(2-methoxyphenyl)-1,3,4-oxadiazole' K6U 
8 'CHLORIDE ION'                              CL  
9 water                                       HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PRO n 
1 3   GLY n 
1 4   ILE n 
1 5   GLU n 
1 6   SER n 
1 7   GLU n 
1 8   THR n 
1 9   PRO n 
1 10  ASN n 
1 11  LEU n 
1 12  ASP n 
1 13  ILE n 
1 14  ILE n 
1 15  GLY n 
1 16  LYS n 
1 17  ARG n 
1 18  ILE n 
1 19  GLU n 
1 20  LYS n 
1 21  ILE n 
1 22  LYS n 
1 23  GLN n 
1 24  GLU n 
1 25  HIS n 
1 26  GLU n 
1 27  THR n 
1 28  SER n 
1 29  TRP n 
1 30  HIS n 
1 31  TYR n 
1 32  ASP n 
1 33  GLN n 
1 34  ASP n 
1 35  HIS n 
1 36  PRO n 
1 37  TYR n 
1 38  LYS n 
1 39  THR n 
1 40  TRP n 
1 41  ALA n 
1 42  TYR n 
1 43  HIS n 
1 44  GLY n 
1 45  SER n 
1 46  TYR n 
1 47  GLU n 
1 48  THR n 
1 49  LYS n 
1 50  GLN n 
1 51  THR n 
1 52  GLY n 
1 53  SER n 
1 54  ALA n 
1 55  SER n 
1 56  SER n 
1 57  MET n 
1 58  VAL n 
1 59  ASN n 
1 60  GLY n 
1 61  VAL n 
1 62  VAL n 
1 63  ARG n 
1 64  LEU n 
1 65  LEU n 
1 66  THR n 
1 67  LYS n 
1 68  PRO n 
1 69  TRP n 
1 70  ASP n 
1 71  ILE n 
1 72  ILE n 
1 73  PRO n 
1 74  MET n 
1 75  VAL n 
1 76  THR n 
1 77  GLN n 
1 78  MET n 
1 79  ALA n 
1 80  MET n 
1 81  THR n 
1 82  ASP n 
1 83  THR n 
1 84  THR n 
1 85  PRO n 
1 86  PHE n 
1 87  GLY n 
1 88  GLN n 
1 89  GLN n 
1 90  ARG n 
1 91  VAL n 
1 92  PHE n 
1 93  LYS n 
1 94  GLU n 
1 95  LYS n 
1 96  VAL n 
1 97  ASP n 
1 98  THR n 
1 99  ARG n 
1 100 THR n 
1 101 GLN n 
1 102 GLU n 
1 103 PRO n 
1 104 LYS n 
1 105 GLU n 
1 106 GLY n 
1 107 THR n 
1 108 LYS n 
1 109 LYS n 
1 110 LEU n 
1 111 MET n 
1 112 LYS n 
1 113 ILE n 
1 114 THR n 
1 115 ALA n 
1 116 GLU n 
1 117 TRP n 
1 118 LEU n 
1 119 TRP n 
1 120 LYS n 
1 121 GLU n 
1 122 LEU n 
1 123 GLY n 
1 124 LYS n 
1 125 LYS n 
1 126 LYS n 
1 127 THR n 
1 128 PRO n 
1 129 ARG n 
1 130 MET n 
1 131 CYS n 
1 132 THR n 
1 133 ARG n 
1 134 GLU n 
1 135 GLU n 
1 136 PHE n 
1 137 THR n 
1 138 ARG n 
1 139 LYS n 
1 140 VAL n 
1 141 ARG n 
1 142 SER n 
1 143 ASN n 
1 144 ALA n 
1 145 ALA n 
1 146 LEU n 
1 147 GLY n 
1 148 ALA n 
1 149 ILE n 
1 150 PHE n 
1 151 THR n 
1 152 ASP n 
1 153 GLU n 
1 154 ASN n 
1 155 LYS n 
1 156 TRP n 
1 157 LYS n 
1 158 SER n 
1 159 ALA n 
1 160 ARG n 
1 161 GLU n 
1 162 ALA n 
1 163 VAL n 
1 164 GLU n 
1 165 ASP n 
1 166 SER n 
1 167 GLY n 
1 168 PHE n 
1 169 TRP n 
1 170 GLU n 
1 171 LEU n 
1 172 VAL n 
1 173 ASP n 
1 174 LYS n 
1 175 GLU n 
1 176 ARG n 
1 177 ASN n 
1 178 LEU n 
1 179 HIS n 
1 180 LEU n 
1 181 GLU n 
1 182 GLY n 
1 183 LYS n 
1 184 CYS n 
1 185 GLU n 
1 186 THR n 
1 187 CYS n 
1 188 VAL n 
1 189 TYR n 
1 190 ASN n 
1 191 MET n 
1 192 MET n 
1 193 GLY n 
1 194 LYS n 
1 195 ARG n 
1 196 GLU n 
1 197 LYS n 
1 198 LYS n 
1 199 LEU n 
1 200 GLY n 
1 201 GLU n 
1 202 PHE n 
1 203 GLY n 
1 204 LYS n 
1 205 ALA n 
1 206 LYS n 
1 207 GLY n 
1 208 SER n 
1 209 ARG n 
1 210 ALA n 
1 211 ILE n 
1 212 TRP n 
1 213 TYR n 
1 214 MET n 
1 215 TRP n 
1 216 LEU n 
1 217 GLY n 
1 218 ALA n 
1 219 ARG n 
1 220 PHE n 
1 221 LEU n 
1 222 GLU n 
1 223 PHE n 
1 224 GLU n 
1 225 ALA n 
1 226 LEU n 
1 227 GLY n 
1 228 PHE n 
1 229 LEU n 
1 230 ASN n 
1 231 GLU n 
1 232 ASP n 
1 233 HIS n 
1 234 TRP n 
1 235 PHE n 
1 236 SER n 
1 237 ARG n 
1 238 GLU n 
1 239 ASN n 
1 240 SER n 
1 241 LEU n 
1 242 SER n 
1 243 GLY n 
1 244 VAL n 
1 245 GLU n 
1 246 GLY n 
1 247 GLU n 
1 248 GLY n 
1 249 LEU n 
1 250 HIS n 
1 251 LYS n 
1 252 LEU n 
1 253 GLY n 
1 254 TYR n 
1 255 ILE n 
1 256 LEU n 
1 257 ARG n 
1 258 ASP n 
1 259 VAL n 
1 260 SER n 
1 261 LYS n 
1 262 LYS n 
1 263 GLU n 
1 264 GLY n 
1 265 GLY n 
1 266 ALA n 
1 267 MET n 
1 268 TYR n 
1 269 ALA n 
1 270 ASP n 
1 271 ASP n 
1 272 THR n 
1 273 ALA n 
1 274 GLY n 
1 275 TRP n 
1 276 ASP n 
1 277 THR n 
1 278 ARG n 
1 279 ILE n 
1 280 THR n 
1 281 LEU n 
1 282 GLU n 
1 283 ASP n 
1 284 LEU n 
1 285 LYS n 
1 286 ASN n 
1 287 GLU n 
1 288 GLU n 
1 289 MET n 
1 290 VAL n 
1 291 THR n 
1 292 ASN n 
1 293 HIS n 
1 294 MET n 
1 295 GLU n 
1 296 GLY n 
1 297 GLU n 
1 298 HIS n 
1 299 LYS n 
1 300 LYS n 
1 301 LEU n 
1 302 ALA n 
1 303 GLU n 
1 304 ALA n 
1 305 ILE n 
1 306 PHE n 
1 307 LYS n 
1 308 LEU n 
1 309 THR n 
1 310 TYR n 
1 311 GLN n 
1 312 ASN n 
1 313 LYS n 
1 314 VAL n 
1 315 VAL n 
1 316 ARG n 
1 317 VAL n 
1 318 GLN n 
1 319 ARG n 
1 320 PRO n 
1 321 THR n 
1 322 PRO n 
1 323 ARG n 
1 324 GLY n 
1 325 THR n 
1 326 VAL n 
1 327 MET n 
1 328 ASP n 
1 329 ILE n 
1 330 ILE n 
1 331 SER n 
1 332 ARG n 
1 333 ARG n 
1 334 ASP n 
1 335 GLN n 
1 336 ARG n 
1 337 GLY n 
1 338 SER n 
1 339 GLY n 
1 340 GLN n 
1 341 VAL n 
1 342 VAL n 
1 343 THR n 
1 344 TYR n 
1 345 GLY n 
1 346 LEU n 
1 347 ASN n 
1 348 THR n 
1 349 PHE n 
1 350 THR n 
1 351 ASN n 
1 352 MET n 
1 353 GLU n 
1 354 ALA n 
1 355 GLN n 
1 356 LEU n 
1 357 ILE n 
1 358 ARG n 
1 359 GLN n 
1 360 MET n 
1 361 GLU n 
1 362 GLY n 
1 363 GLU n 
1 364 GLY n 
1 365 VAL n 
1 366 PHE n 
1 367 LYS n 
1 368 SER n 
1 369 ILE n 
1 370 GLN n 
1 371 HIS n 
1 372 LEU n 
1 373 THR n 
1 374 VAL n 
1 375 THR n 
1 376 GLU n 
1 377 GLU n 
1 378 ILE n 
1 379 ALA n 
1 380 VAL n 
1 381 LYS n 
1 382 ASN n 
1 383 TRP n 
1 384 LEU n 
1 385 VAL n 
1 386 ARG n 
1 387 VAL n 
1 388 GLY n 
1 389 ARG n 
1 390 GLU n 
1 391 ARG n 
1 392 LEU n 
1 393 SER n 
1 394 ARG n 
1 395 MET n 
1 396 ALA n 
1 397 ILE n 
1 398 SER n 
1 399 GLY n 
1 400 ASP n 
1 401 ASP n 
1 402 CYS n 
1 403 VAL n 
1 404 VAL n 
1 405 LYS n 
1 406 PRO n 
1 407 LEU n 
1 408 ASP n 
1 409 ASP n 
1 410 ARG n 
1 411 PHE n 
1 412 ALA n 
1 413 SER n 
1 414 ALA n 
1 415 LEU n 
1 416 THR n 
1 417 ALA n 
1 418 LEU n 
1 419 ASN n 
1 420 ASP n 
1 421 MET n 
1 422 GLY n 
1 423 LYS n 
1 424 VAL n 
1 425 ARG n 
1 426 LYS n 
1 427 ASP n 
1 428 ILE n 
1 429 GLN n 
1 430 GLN n 
1 431 TRP n 
1 432 GLU n 
1 433 PRO n 
1 434 SER n 
1 435 ARG n 
1 436 GLY n 
1 437 TRP n 
1 438 ASN n 
1 439 ASP n 
1 440 TRP n 
1 441 THR n 
1 442 GLN n 
1 443 VAL n 
1 444 PRO n 
1 445 PHE n 
1 446 CYS n 
1 447 SER n 
1 448 HIS n 
1 449 HIS n 
1 450 PHE n 
1 451 HIS n 
1 452 GLU n 
1 453 LEU n 
1 454 ILE n 
1 455 MET n 
1 456 LYS n 
1 457 ASP n 
1 458 GLY n 
1 459 ARG n 
1 460 VAL n 
1 461 LEU n 
1 462 VAL n 
1 463 VAL n 
1 464 PRO n 
1 465 CYS n 
1 466 ARG n 
1 467 ASN n 
1 468 GLN n 
1 469 ASP n 
1 470 GLU n 
1 471 LEU n 
1 472 ILE n 
1 473 GLY n 
1 474 ARG n 
1 475 ALA n 
1 476 ARG n 
1 477 ILE n 
1 478 SER n 
1 479 GLN n 
1 480 GLY n 
1 481 ALA n 
1 482 GLY n 
1 483 TRP n 
1 484 SER n 
1 485 LEU n 
1 486 ARG n 
1 487 GLU n 
1 488 THR n 
1 489 ALA n 
1 490 CYS n 
1 491 LEU n 
1 492 GLY n 
1 493 LYS n 
1 494 SER n 
1 495 TYR n 
1 496 ALA n 
1 497 GLN n 
1 498 MET n 
1 499 TRP n 
1 500 SER n 
1 501 LEU n 
1 502 MET n 
1 503 TYR n 
1 504 PHE n 
1 505 HIS n 
1 506 ARG n 
1 507 ARG n 
1 508 ASP n 
1 509 LEU n 
1 510 ARG n 
1 511 LEU n 
1 512 ALA n 
1 513 ALA n 
1 514 ASN n 
1 515 ALA n 
1 516 ILE n 
1 517 CYS n 
1 518 SER n 
1 519 ALA n 
1 520 VAL n 
1 521 PRO n 
1 522 SER n 
1 523 HIS n 
1 524 TRP n 
1 525 VAL n 
1 526 PRO n 
1 527 THR n 
1 528 SER n 
1 529 ARG n 
1 530 THR n 
1 531 THR n 
1 532 TRP n 
1 533 SER n 
1 534 ILE n 
1 535 HIS n 
1 536 ALA n 
1 537 THR n 
1 538 HIS n 
1 539 GLU n 
1 540 TRP n 
1 541 MET n 
1 542 THR n 
1 543 THR n 
1 544 GLU n 
1 545 ASP n 
1 546 MET n 
1 547 LEU n 
1 548 THR n 
1 549 VAL n 
1 550 TRP n 
1 551 ASN n 
1 552 ARG n 
1 553 VAL n 
1 554 TRP n 
1 555 ILE n 
1 556 GLN n 
1 557 GLU n 
1 558 ASN n 
1 559 PRO n 
1 560 TRP n 
1 561 MET n 
1 562 GLU n 
1 563 ASP n 
1 564 LYS n 
1 565 THR n 
1 566 PRO n 
1 567 VAL n 
1 568 GLU n 
1 569 SER n 
1 570 TRP n 
1 571 GLU n 
1 572 GLU n 
1 573 ILE n 
1 574 PRO n 
1 575 TYR n 
1 576 LEU n 
1 577 GLY n 
1 578 LYS n 
1 579 ARG n 
1 580 GLU n 
1 581 ASP n 
1 582 GLN n 
1 583 TRP n 
1 584 CYS n 
1 585 GLY n 
1 586 SER n 
1 587 LEU n 
1 588 ILE n 
1 589 GLY n 
1 590 LEU n 
1 591 THR n 
1 592 SER n 
1 593 ARG n 
1 594 ALA n 
1 595 THR n 
1 596 TRP n 
1 597 ALA n 
1 598 LYS n 
1 599 ASN n 
1 600 ILE n 
1 601 GLN n 
1 602 THR n 
1 603 ALA n 
1 604 ILE n 
1 605 ASN n 
1 606 GLN n 
1 607 VAL n 
1 608 ARG n 
1 609 SER n 
1 610 LEU n 
1 611 ILE n 
1 612 GLY n 
1 613 ASN n 
1 614 GLU n 
1 615 GLU n 
1 616 TYR n 
1 617 THR n 
1 618 ASP n 
1 619 TYR n 
1 620 MET n 
1 621 PRO n 
1 622 SER n 
1 623 MET n 
1 624 LYS n 
1 625 ARG n 
1 626 PHE n 
1 627 ARG n 
1 628 ARG n 
1 629 GLU n 
1 630 GLU n 
1 631 GLU n 
1 632 GLU n 
1 633 ALA n 
1 634 GLY n 
1 635 VAL n 
1 636 LEU n 
1 637 TRP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   637 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'dengue virus type 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     11060 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                     ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                    ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                  ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                             ? 'C4 H7 N O4'     133.103 
CL  non-polymer         . 'CHLORIDE ION'                              ? 'Cl -1'          35.453  
CYS 'L-peptide linking' y CYSTEINE                                    ? 'C3 H7 N O2 S'   121.158 
DMS non-polymer         . 'DIMETHYL SULFOXIDE'                        ? 'C2 H6 O S'      78.133  
GLN 'L-peptide linking' y GLUTAMINE                                   ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                             ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                     ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                   ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                       ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                  ? 'C6 H13 N O2'    131.173 
K6U non-polymer         . '(2M)-2-(2-methoxyphenyl)-1,3,4-oxadiazole' ? 'C9 H8 N2 O2'    176.172 
LEU 'L-peptide linking' y LEUCINE                                     ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                      ? 'C6 H15 N2 O2 1' 147.195 
MES non-polymer         . '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'      ? 'C6 H13 N O4 S'  195.237 
MET 'L-peptide linking' y METHIONINE                                  ? 'C5 H11 N O2 S'  149.211 
PEG non-polymer         . 'DI(HYDROXYETHYL)ETHER'                     ? 'C4 H10 O3'      106.120 
PHE 'L-peptide linking' y PHENYLALANINE                               ? 'C9 H11 N O2'    165.189 
PO4 non-polymer         . 'PHOSPHATE ION'                             ? 'O4 P -3'        94.971  
PRO 'L-peptide linking' y PROLINE                                     ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                      ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                   ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                  ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                    ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                                      ? 'C5 H11 N O2'    117.146 
ZN  non-polymer         . 'ZINC ION'                                  ? 'Zn 2'           65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   264 ?   ?   ?   A . n 
A 1 2   PRO 2   265 ?   ?   ?   A . n 
A 1 3   GLY 3   266 ?   ?   ?   A . n 
A 1 4   ILE 4   267 ?   ?   ?   A . n 
A 1 5   GLU 5   268 ?   ?   ?   A . n 
A 1 6   SER 6   269 ?   ?   ?   A . n 
A 1 7   GLU 7   270 ?   ?   ?   A . n 
A 1 8   THR 8   271 ?   ?   ?   A . n 
A 1 9   PRO 9   272 ?   ?   ?   A . n 
A 1 10  ASN 10  273 273 ASN ASN A . n 
A 1 11  LEU 11  274 274 LEU LEU A . n 
A 1 12  ASP 12  275 275 ASP ASP A . n 
A 1 13  ILE 13  276 276 ILE ILE A . n 
A 1 14  ILE 14  277 277 ILE ILE A . n 
A 1 15  GLY 15  278 278 GLY GLY A . n 
A 1 16  LYS 16  279 279 LYS LYS A . n 
A 1 17  ARG 17  280 280 ARG ARG A . n 
A 1 18  ILE 18  281 281 ILE ILE A . n 
A 1 19  GLU 19  282 282 GLU GLU A . n 
A 1 20  LYS 20  283 283 LYS LYS A . n 
A 1 21  ILE 21  284 284 ILE ILE A . n 
A 1 22  LYS 22  285 285 LYS LYS A . n 
A 1 23  GLN 23  286 286 GLN GLN A . n 
A 1 24  GLU 24  287 287 GLU GLU A . n 
A 1 25  HIS 25  288 288 HIS HIS A . n 
A 1 26  GLU 26  289 289 GLU GLU A . n 
A 1 27  THR 27  290 290 THR THR A . n 
A 1 28  SER 28  291 291 SER SER A . n 
A 1 29  TRP 29  292 292 TRP TRP A . n 
A 1 30  HIS 30  293 293 HIS HIS A . n 
A 1 31  TYR 31  294 294 TYR TYR A . n 
A 1 32  ASP 32  295 295 ASP ASP A . n 
A 1 33  GLN 33  296 296 GLN GLN A . n 
A 1 34  ASP 34  297 297 ASP ASP A . n 
A 1 35  HIS 35  298 298 HIS HIS A . n 
A 1 36  PRO 36  299 299 PRO PRO A . n 
A 1 37  TYR 37  300 300 TYR TYR A . n 
A 1 38  LYS 38  301 301 LYS LYS A . n 
A 1 39  THR 39  302 302 THR THR A . n 
A 1 40  TRP 40  303 303 TRP TRP A . n 
A 1 41  ALA 41  304 304 ALA ALA A . n 
A 1 42  TYR 42  305 305 TYR TYR A . n 
A 1 43  HIS 43  306 306 HIS HIS A . n 
A 1 44  GLY 44  307 307 GLY GLY A . n 
A 1 45  SER 45  308 308 SER SER A . n 
A 1 46  TYR 46  309 309 TYR TYR A . n 
A 1 47  GLU 47  310 310 GLU GLU A . n 
A 1 48  THR 48  311 311 THR THR A . n 
A 1 49  LYS 49  312 ?   ?   ?   A . n 
A 1 50  GLN 50  313 ?   ?   ?   A . n 
A 1 51  THR 51  314 ?   ?   ?   A . n 
A 1 52  GLY 52  315 ?   ?   ?   A . n 
A 1 53  SER 53  316 ?   ?   ?   A . n 
A 1 54  ALA 54  317 ?   ?   ?   A . n 
A 1 55  SER 55  318 ?   ?   ?   A . n 
A 1 56  SER 56  319 319 SER SER A . n 
A 1 57  MET 57  320 320 MET MET A . n 
A 1 58  VAL 58  321 321 VAL VAL A . n 
A 1 59  ASN 59  322 322 ASN ASN A . n 
A 1 60  GLY 60  323 323 GLY GLY A . n 
A 1 61  VAL 61  324 324 VAL VAL A . n 
A 1 62  VAL 62  325 325 VAL VAL A . n 
A 1 63  ARG 63  326 326 ARG ARG A . n 
A 1 64  LEU 64  327 327 LEU LEU A . n 
A 1 65  LEU 65  328 328 LEU LEU A . n 
A 1 66  THR 66  329 329 THR THR A . n 
A 1 67  LYS 67  330 330 LYS LYS A . n 
A 1 68  PRO 68  331 331 PRO PRO A . n 
A 1 69  TRP 69  332 332 TRP TRP A . n 
A 1 70  ASP 70  333 333 ASP ASP A . n 
A 1 71  ILE 71  334 334 ILE ILE A . n 
A 1 72  ILE 72  335 335 ILE ILE A . n 
A 1 73  PRO 73  336 336 PRO PRO A . n 
A 1 74  MET 74  337 337 MET MET A . n 
A 1 75  VAL 75  338 338 VAL VAL A . n 
A 1 76  THR 76  339 339 THR THR A . n 
A 1 77  GLN 77  340 340 GLN GLN A . n 
A 1 78  MET 78  341 341 MET MET A . n 
A 1 79  ALA 79  342 342 ALA ALA A . n 
A 1 80  MET 80  343 343 MET MET A . n 
A 1 81  THR 81  344 344 THR GLY A . n 
A 1 82  ASP 82  345 ?   ?   ?   A . n 
A 1 83  THR 83  346 ?   ?   ?   A . n 
A 1 84  THR 84  347 ?   ?   ?   A . n 
A 1 85  PRO 85  348 ?   ?   ?   A . n 
A 1 86  PHE 86  349 ?   ?   ?   A . n 
A 1 87  GLY 87  350 ?   ?   ?   A . n 
A 1 88  GLN 88  351 ?   ?   ?   A . n 
A 1 89  GLN 89  352 ?   ?   ?   A . n 
A 1 90  ARG 90  353 ?   ?   ?   A . n 
A 1 91  VAL 91  354 ?   ?   ?   A . n 
A 1 92  PHE 92  355 ?   ?   ?   A . n 
A 1 93  LYS 93  356 ?   ?   ?   A . n 
A 1 94  GLU 94  357 357 GLU GLU A . n 
A 1 95  LYS 95  358 358 LYS LYS A . n 
A 1 96  VAL 96  359 359 VAL VAL A . n 
A 1 97  ASP 97  360 360 ASP ASP A . n 
A 1 98  THR 98  361 361 THR THR A . n 
A 1 99  ARG 99  362 362 ARG ARG A . n 
A 1 100 THR 100 363 363 THR THR A . n 
A 1 101 GLN 101 364 364 GLN GLN A . n 
A 1 102 GLU 102 365 365 GLU GLU A . n 
A 1 103 PRO 103 366 366 PRO PRO A . n 
A 1 104 LYS 104 367 367 LYS LYS A . n 
A 1 105 GLU 105 368 368 GLU GLU A . n 
A 1 106 GLY 106 369 369 GLY GLY A . n 
A 1 107 THR 107 370 370 THR THR A . n 
A 1 108 LYS 108 371 371 LYS LYS A . n 
A 1 109 LYS 109 372 372 LYS LYS A . n 
A 1 110 LEU 110 373 373 LEU LEU A . n 
A 1 111 MET 111 374 374 MET MET A . n 
A 1 112 LYS 112 375 375 LYS LYS A . n 
A 1 113 ILE 113 376 376 ILE ILE A . n 
A 1 114 THR 114 377 377 THR THR A . n 
A 1 115 ALA 115 378 378 ALA ALA A . n 
A 1 116 GLU 116 379 379 GLU GLU A . n 
A 1 117 TRP 117 380 380 TRP TRP A . n 
A 1 118 LEU 118 381 381 LEU LEU A . n 
A 1 119 TRP 119 382 382 TRP TRP A . n 
A 1 120 LYS 120 383 383 LYS LYS A . n 
A 1 121 GLU 121 384 384 GLU GLU A . n 
A 1 122 LEU 122 385 385 LEU LEU A . n 
A 1 123 GLY 123 386 386 GLY GLY A . n 
A 1 124 LYS 124 387 387 LYS LYS A . n 
A 1 125 LYS 125 388 388 LYS LYS A . n 
A 1 126 LYS 126 389 389 LYS LYS A . n 
A 1 127 THR 127 390 390 THR THR A . n 
A 1 128 PRO 128 391 391 PRO PRO A . n 
A 1 129 ARG 129 392 392 ARG ARG A . n 
A 1 130 MET 130 393 393 MET MET A . n 
A 1 131 CYS 131 394 394 CYS CYS A . n 
A 1 132 THR 132 395 395 THR THR A . n 
A 1 133 ARG 133 396 396 ARG ARG A . n 
A 1 134 GLU 134 397 397 GLU GLU A . n 
A 1 135 GLU 135 398 398 GLU GLU A . n 
A 1 136 PHE 136 399 399 PHE PHE A . n 
A 1 137 THR 137 400 400 THR THR A . n 
A 1 138 ARG 138 401 401 ARG ARG A . n 
A 1 139 LYS 139 402 402 LYS LYS A . n 
A 1 140 VAL 140 403 403 VAL VAL A . n 
A 1 141 ARG 141 404 404 ARG ARG A . n 
A 1 142 SER 142 405 405 SER SER A . n 
A 1 143 ASN 143 406 406 ASN ASN A . n 
A 1 144 ALA 144 407 407 ALA ALA A . n 
A 1 145 ALA 145 408 408 ALA ALA A . n 
A 1 146 LEU 146 409 409 LEU LEU A . n 
A 1 147 GLY 147 410 410 GLY GLY A . n 
A 1 148 ALA 148 411 411 ALA ALA A . n 
A 1 149 ILE 149 412 ?   ?   ?   A . n 
A 1 150 PHE 150 413 ?   ?   ?   A . n 
A 1 151 THR 151 414 ?   ?   ?   A . n 
A 1 152 ASP 152 415 ?   ?   ?   A . n 
A 1 153 GLU 153 416 ?   ?   ?   A . n 
A 1 154 ASN 154 417 ?   ?   ?   A . n 
A 1 155 LYS 155 418 ?   ?   ?   A . n 
A 1 156 TRP 156 419 419 TRP TRP A . n 
A 1 157 LYS 157 420 420 LYS LYS A . n 
A 1 158 SER 158 421 421 SER SER A . n 
A 1 159 ALA 159 422 422 ALA ALA A . n 
A 1 160 ARG 160 423 423 ARG ARG A . n 
A 1 161 GLU 161 424 424 GLU GLU A . n 
A 1 162 ALA 162 425 425 ALA ALA A . n 
A 1 163 VAL 163 426 426 VAL VAL A . n 
A 1 164 GLU 164 427 427 GLU GLU A . n 
A 1 165 ASP 165 428 428 ASP ASP A . n 
A 1 166 SER 166 429 429 SER SER A . n 
A 1 167 GLY 167 430 430 GLY GLY A . n 
A 1 168 PHE 168 431 431 PHE PHE A . n 
A 1 169 TRP 169 432 432 TRP TRP A . n 
A 1 170 GLU 170 433 433 GLU GLU A . n 
A 1 171 LEU 171 434 434 LEU LEU A . n 
A 1 172 VAL 172 435 435 VAL VAL A . n 
A 1 173 ASP 173 436 436 ASP ASP A . n 
A 1 174 LYS 174 437 437 LYS LYS A . n 
A 1 175 GLU 175 438 438 GLU GLU A . n 
A 1 176 ARG 176 439 439 ARG ARG A . n 
A 1 177 ASN 177 440 440 ASN ASN A . n 
A 1 178 LEU 178 441 441 LEU LEU A . n 
A 1 179 HIS 179 442 442 HIS HIS A . n 
A 1 180 LEU 180 443 443 LEU LEU A . n 
A 1 181 GLU 181 444 444 GLU GLU A . n 
A 1 182 GLY 182 445 445 GLY GLY A . n 
A 1 183 LYS 183 446 446 LYS LYS A . n 
A 1 184 CYS 184 447 447 CYS CYS A . n 
A 1 185 GLU 185 448 448 GLU GLU A . n 
A 1 186 THR 186 449 449 THR THR A . n 
A 1 187 CYS 187 450 450 CYS CYS A . n 
A 1 188 VAL 188 451 451 VAL VAL A . n 
A 1 189 TYR 189 452 452 TYR TYR A . n 
A 1 190 ASN 190 453 453 ASN ASN A . n 
A 1 191 MET 191 454 454 MET MET A . n 
A 1 192 MET 192 455 455 MET MET A . n 
A 1 193 GLY 193 456 ?   ?   ?   A . n 
A 1 194 LYS 194 457 ?   ?   ?   A . n 
A 1 195 ARG 195 458 ?   ?   ?   A . n 
A 1 196 GLU 196 459 ?   ?   ?   A . n 
A 1 197 LYS 197 460 ?   ?   ?   A . n 
A 1 198 LYS 198 461 ?   ?   ?   A . n 
A 1 199 LEU 199 462 ?   ?   ?   A . n 
A 1 200 GLY 200 463 ?   ?   ?   A . n 
A 1 201 GLU 201 464 ?   ?   ?   A . n 
A 1 202 PHE 202 465 ?   ?   ?   A . n 
A 1 203 GLY 203 466 ?   ?   ?   A . n 
A 1 204 LYS 204 467 ?   ?   ?   A . n 
A 1 205 ALA 205 468 ?   ?   ?   A . n 
A 1 206 LYS 206 469 ?   ?   ?   A . n 
A 1 207 GLY 207 470 ?   ?   ?   A . n 
A 1 208 SER 208 471 ?   ?   ?   A . n 
A 1 209 ARG 209 472 ?   ?   ?   A . n 
A 1 210 ALA 210 473 473 ALA ALA A . n 
A 1 211 ILE 211 474 474 ILE ILE A . n 
A 1 212 TRP 212 475 475 TRP TRP A . n 
A 1 213 TYR 213 476 476 TYR TYR A . n 
A 1 214 MET 214 477 477 MET MET A . n 
A 1 215 TRP 215 478 478 TRP TRP A . n 
A 1 216 LEU 216 479 479 LEU LEU A . n 
A 1 217 GLY 217 480 480 GLY GLY A . n 
A 1 218 ALA 218 481 481 ALA ALA A . n 
A 1 219 ARG 219 482 482 ARG ARG A . n 
A 1 220 PHE 220 483 483 PHE PHE A . n 
A 1 221 LEU 221 484 484 LEU LEU A . n 
A 1 222 GLU 222 485 485 GLU GLU A . n 
A 1 223 PHE 223 486 486 PHE PHE A . n 
A 1 224 GLU 224 487 487 GLU GLU A . n 
A 1 225 ALA 225 488 488 ALA ALA A . n 
A 1 226 LEU 226 489 489 LEU LEU A . n 
A 1 227 GLY 227 490 490 GLY GLY A . n 
A 1 228 PHE 228 491 491 PHE PHE A . n 
A 1 229 LEU 229 492 492 LEU LEU A . n 
A 1 230 ASN 230 493 493 ASN ASN A . n 
A 1 231 GLU 231 494 494 GLU GLU A . n 
A 1 232 ASP 232 495 495 ASP ASP A . n 
A 1 233 HIS 233 496 496 HIS HIS A . n 
A 1 234 TRP 234 497 497 TRP TRP A . n 
A 1 235 PHE 235 498 498 PHE PHE A . n 
A 1 236 SER 236 499 499 SER SER A . n 
A 1 237 ARG 237 500 500 ARG ARG A . n 
A 1 238 GLU 238 501 501 GLU GLU A . n 
A 1 239 ASN 239 502 502 ASN ASN A . n 
A 1 240 SER 240 503 503 SER SER A . n 
A 1 241 LEU 241 504 504 LEU LEU A . n 
A 1 242 SER 242 505 505 SER SER A . n 
A 1 243 GLY 243 506 506 GLY GLY A . n 
A 1 244 VAL 244 507 507 VAL VAL A . n 
A 1 245 GLU 245 508 508 GLU GLU A . n 
A 1 246 GLY 246 509 509 GLY GLY A . n 
A 1 247 GLU 247 510 510 GLU GLU A . n 
A 1 248 GLY 248 511 511 GLY GLY A . n 
A 1 249 LEU 249 512 512 LEU LEU A . n 
A 1 250 HIS 250 513 513 HIS HIS A . n 
A 1 251 LYS 251 514 514 LYS LYS A . n 
A 1 252 LEU 252 515 515 LEU LEU A . n 
A 1 253 GLY 253 516 516 GLY GLY A . n 
A 1 254 TYR 254 517 517 TYR TYR A . n 
A 1 255 ILE 255 518 518 ILE ILE A . n 
A 1 256 LEU 256 519 519 LEU LEU A . n 
A 1 257 ARG 257 520 520 ARG ARG A . n 
A 1 258 ASP 258 521 521 ASP ASP A . n 
A 1 259 VAL 259 522 522 VAL VAL A . n 
A 1 260 SER 260 523 523 SER SER A . n 
A 1 261 LYS 261 524 524 LYS LYS A . n 
A 1 262 LYS 262 525 525 LYS LYS A . n 
A 1 263 GLU 263 526 526 GLU GLU A . n 
A 1 264 GLY 264 527 527 GLY GLY A . n 
A 1 265 GLY 265 528 528 GLY GLY A . n 
A 1 266 ALA 266 529 529 ALA ALA A . n 
A 1 267 MET 267 530 530 MET MET A . n 
A 1 268 TYR 268 531 531 TYR TYR A . n 
A 1 269 ALA 269 532 532 ALA ALA A . n 
A 1 270 ASP 270 533 533 ASP ASP A . n 
A 1 271 ASP 271 534 534 ASP ASP A . n 
A 1 272 THR 272 535 535 THR THR A . n 
A 1 273 ALA 273 536 536 ALA ALA A . n 
A 1 274 GLY 274 537 537 GLY GLY A . n 
A 1 275 TRP 275 538 538 TRP TRP A . n 
A 1 276 ASP 276 539 539 ASP ASP A . n 
A 1 277 THR 277 540 540 THR THR A . n 
A 1 278 ARG 278 541 541 ARG ARG A . n 
A 1 279 ILE 279 542 542 ILE ILE A . n 
A 1 280 THR 280 543 543 THR THR A . n 
A 1 281 LEU 281 544 544 LEU LEU A . n 
A 1 282 GLU 282 545 545 GLU GLU A . n 
A 1 283 ASP 283 546 546 ASP ASP A . n 
A 1 284 LEU 284 547 547 LEU LEU A . n 
A 1 285 LYS 285 548 548 LYS LYS A . n 
A 1 286 ASN 286 549 549 ASN ASN A . n 
A 1 287 GLU 287 550 550 GLU GLU A . n 
A 1 288 GLU 288 551 551 GLU GLU A . n 
A 1 289 MET 289 552 552 MET MET A . n 
A 1 290 VAL 290 553 553 VAL VAL A . n 
A 1 291 THR 291 554 554 THR THR A . n 
A 1 292 ASN 292 555 555 ASN ASN A . n 
A 1 293 HIS 293 556 556 HIS HIS A . n 
A 1 294 MET 294 557 557 MET MET A . n 
A 1 295 GLU 295 558 558 GLU GLU A . n 
A 1 296 GLY 296 559 559 GLY GLY A . n 
A 1 297 GLU 297 560 560 GLU GLU A . n 
A 1 298 HIS 298 561 561 HIS HIS A . n 
A 1 299 LYS 299 562 562 LYS LYS A . n 
A 1 300 LYS 300 563 563 LYS LYS A . n 
A 1 301 LEU 301 564 564 LEU LEU A . n 
A 1 302 ALA 302 565 565 ALA ALA A . n 
A 1 303 GLU 303 566 566 GLU GLU A . n 
A 1 304 ALA 304 567 567 ALA ALA A . n 
A 1 305 ILE 305 568 568 ILE ILE A . n 
A 1 306 PHE 306 569 569 PHE PHE A . n 
A 1 307 LYS 307 570 570 LYS LYS A . n 
A 1 308 LEU 308 571 571 LEU LEU A . n 
A 1 309 THR 309 572 572 THR THR A . n 
A 1 310 TYR 310 573 573 TYR TYR A . n 
A 1 311 GLN 311 574 574 GLN GLN A . n 
A 1 312 ASN 312 575 575 ASN ASN A . n 
A 1 313 LYS 313 576 576 LYS LYS A . n 
A 1 314 VAL 314 577 577 VAL VAL A . n 
A 1 315 VAL 315 578 578 VAL VAL A . n 
A 1 316 ARG 316 579 579 ARG ARG A . n 
A 1 317 VAL 317 580 580 VAL VAL A . n 
A 1 318 GLN 318 581 581 GLN GLN A . n 
A 1 319 ARG 319 582 582 ARG ARG A . n 
A 1 320 PRO 320 583 583 PRO PRO A . n 
A 1 321 THR 321 584 584 THR THR A . n 
A 1 322 PRO 322 585 ?   ?   ?   A . n 
A 1 323 ARG 323 586 ?   ?   ?   A . n 
A 1 324 GLY 324 587 ?   ?   ?   A . n 
A 1 325 THR 325 588 588 THR THR A . n 
A 1 326 VAL 326 589 589 VAL VAL A . n 
A 1 327 MET 327 590 590 MET MET A . n 
A 1 328 ASP 328 591 591 ASP ASP A . n 
A 1 329 ILE 329 592 592 ILE ILE A . n 
A 1 330 ILE 330 593 593 ILE ILE A . n 
A 1 331 SER 331 594 594 SER SER A . n 
A 1 332 ARG 332 595 595 ARG ARG A . n 
A 1 333 ARG 333 596 596 ARG ARG A . n 
A 1 334 ASP 334 597 597 ASP ASP A . n 
A 1 335 GLN 335 598 598 GLN GLN A . n 
A 1 336 ARG 336 599 599 ARG ARG A . n 
A 1 337 GLY 337 600 600 GLY GLY A . n 
A 1 338 SER 338 601 601 SER SER A . n 
A 1 339 GLY 339 602 602 GLY GLY A . n 
A 1 340 GLN 340 603 603 GLN GLN A . n 
A 1 341 VAL 341 604 604 VAL VAL A . n 
A 1 342 VAL 342 605 605 VAL VAL A . n 
A 1 343 THR 343 606 606 THR THR A . n 
A 1 344 TYR 344 607 607 TYR TYR A . n 
A 1 345 GLY 345 608 608 GLY GLY A . n 
A 1 346 LEU 346 609 609 LEU LEU A . n 
A 1 347 ASN 347 610 610 ASN ASN A . n 
A 1 348 THR 348 611 611 THR THR A . n 
A 1 349 PHE 349 612 612 PHE PHE A . n 
A 1 350 THR 350 613 613 THR THR A . n 
A 1 351 ASN 351 614 614 ASN ASN A . n 
A 1 352 MET 352 615 615 MET MET A . n 
A 1 353 GLU 353 616 616 GLU GLU A . n 
A 1 354 ALA 354 617 617 ALA ALA A . n 
A 1 355 GLN 355 618 618 GLN GLN A . n 
A 1 356 LEU 356 619 619 LEU LEU A . n 
A 1 357 ILE 357 620 620 ILE ILE A . n 
A 1 358 ARG 358 621 621 ARG ARG A . n 
A 1 359 GLN 359 622 622 GLN GLN A . n 
A 1 360 MET 360 623 623 MET MET A . n 
A 1 361 GLU 361 624 624 GLU GLU A . n 
A 1 362 GLY 362 625 625 GLY GLY A . n 
A 1 363 GLU 363 626 626 GLU GLU A . n 
A 1 364 GLY 364 627 627 GLY GLY A . n 
A 1 365 VAL 365 628 628 VAL VAL A . n 
A 1 366 PHE 366 629 629 PHE PHE A . n 
A 1 367 LYS 367 630 630 LYS LYS A . n 
A 1 368 SER 368 631 631 SER SER A . n 
A 1 369 ILE 369 632 632 ILE ILE A . n 
A 1 370 GLN 370 633 633 GLN GLN A . n 
A 1 371 HIS 371 634 634 HIS HIS A . n 
A 1 372 LEU 372 635 635 LEU LEU A . n 
A 1 373 THR 373 636 636 THR THR A . n 
A 1 374 VAL 374 637 637 VAL VAL A . n 
A 1 375 THR 375 638 638 THR THR A . n 
A 1 376 GLU 376 639 639 GLU GLU A . n 
A 1 377 GLU 377 640 640 GLU GLU A . n 
A 1 378 ILE 378 641 641 ILE ILE A . n 
A 1 379 ALA 379 642 642 ALA ALA A . n 
A 1 380 VAL 380 643 643 VAL VAL A . n 
A 1 381 LYS 381 644 644 LYS LYS A . n 
A 1 382 ASN 382 645 645 ASN ASN A . n 
A 1 383 TRP 383 646 646 TRP TRP A . n 
A 1 384 LEU 384 647 647 LEU LEU A . n 
A 1 385 VAL 385 648 648 VAL VAL A . n 
A 1 386 ARG 386 649 649 ARG ARG A . n 
A 1 387 VAL 387 650 650 VAL VAL A . n 
A 1 388 GLY 388 651 651 GLY GLY A . n 
A 1 389 ARG 389 652 652 ARG ARG A . n 
A 1 390 GLU 390 653 653 GLU GLU A . n 
A 1 391 ARG 391 654 654 ARG ARG A . n 
A 1 392 LEU 392 655 655 LEU LEU A . n 
A 1 393 SER 393 656 656 SER SER A . n 
A 1 394 ARG 394 657 657 ARG ARG A . n 
A 1 395 MET 395 658 658 MET MET A . n 
A 1 396 ALA 396 659 659 ALA ALA A . n 
A 1 397 ILE 397 660 660 ILE ILE A . n 
A 1 398 SER 398 661 661 SER SER A . n 
A 1 399 GLY 399 662 662 GLY GLY A . n 
A 1 400 ASP 400 663 663 ASP ASP A . n 
A 1 401 ASP 401 664 664 ASP ASP A . n 
A 1 402 CYS 402 665 665 CYS CYS A . n 
A 1 403 VAL 403 666 666 VAL VAL A . n 
A 1 404 VAL 404 667 667 VAL VAL A . n 
A 1 405 LYS 405 668 668 LYS LYS A . n 
A 1 406 PRO 406 669 669 PRO PRO A . n 
A 1 407 LEU 407 670 670 LEU LEU A . n 
A 1 408 ASP 408 671 671 ASP ASP A . n 
A 1 409 ASP 409 672 672 ASP ASP A . n 
A 1 410 ARG 410 673 673 ARG ARG A . n 
A 1 411 PHE 411 674 674 PHE PHE A . n 
A 1 412 ALA 412 675 675 ALA ALA A . n 
A 1 413 SER 413 676 676 SER SER A . n 
A 1 414 ALA 414 677 677 ALA ALA A . n 
A 1 415 LEU 415 678 678 LEU LEU A . n 
A 1 416 THR 416 679 679 THR THR A . n 
A 1 417 ALA 417 680 680 ALA ALA A . n 
A 1 418 LEU 418 681 681 LEU LEU A . n 
A 1 419 ASN 419 682 682 ASN ASN A . n 
A 1 420 ASP 420 683 683 ASP ASP A . n 
A 1 421 MET 421 684 684 MET MET A . n 
A 1 422 GLY 422 685 685 GLY GLY A . n 
A 1 423 LYS 423 686 686 LYS LYS A . n 
A 1 424 VAL 424 687 687 VAL VAL A . n 
A 1 425 ARG 425 688 688 ARG ARG A . n 
A 1 426 LYS 426 689 689 LYS LYS A . n 
A 1 427 ASP 427 690 690 ASP ASP A . n 
A 1 428 ILE 428 691 691 ILE ILE A . n 
A 1 429 GLN 429 692 692 GLN GLN A . n 
A 1 430 GLN 430 693 693 GLN GLN A . n 
A 1 431 TRP 431 694 694 TRP TRP A . n 
A 1 432 GLU 432 695 695 GLU GLU A . n 
A 1 433 PRO 433 696 696 PRO PRO A . n 
A 1 434 SER 434 697 697 SER SER A . n 
A 1 435 ARG 435 698 698 ARG ARG A . n 
A 1 436 GLY 436 699 699 GLY GLY A . n 
A 1 437 TRP 437 700 700 TRP TRP A . n 
A 1 438 ASN 438 701 701 ASN ASN A . n 
A 1 439 ASP 439 702 702 ASP ASP A . n 
A 1 440 TRP 440 703 703 TRP TRP A . n 
A 1 441 THR 441 704 704 THR THR A . n 
A 1 442 GLN 442 705 705 GLN GLN A . n 
A 1 443 VAL 443 706 706 VAL VAL A . n 
A 1 444 PRO 444 707 707 PRO PRO A . n 
A 1 445 PHE 445 708 708 PHE PHE A . n 
A 1 446 CYS 446 709 709 CYS CYS A . n 
A 1 447 SER 447 710 710 SER SER A . n 
A 1 448 HIS 448 711 711 HIS HIS A . n 
A 1 449 HIS 449 712 712 HIS HIS A . n 
A 1 450 PHE 450 713 713 PHE PHE A . n 
A 1 451 HIS 451 714 714 HIS HIS A . n 
A 1 452 GLU 452 715 715 GLU GLU A . n 
A 1 453 LEU 453 716 716 LEU LEU A . n 
A 1 454 ILE 454 717 717 ILE ILE A . n 
A 1 455 MET 455 718 718 MET MET A . n 
A 1 456 LYS 456 719 719 LYS LYS A . n 
A 1 457 ASP 457 720 720 ASP ASP A . n 
A 1 458 GLY 458 721 721 GLY GLY A . n 
A 1 459 ARG 459 722 722 ARG ARG A . n 
A 1 460 VAL 460 723 723 VAL VAL A . n 
A 1 461 LEU 461 724 724 LEU LEU A . n 
A 1 462 VAL 462 725 725 VAL VAL A . n 
A 1 463 VAL 463 726 726 VAL VAL A . n 
A 1 464 PRO 464 727 727 PRO PRO A . n 
A 1 465 CYS 465 728 728 CYS CYS A . n 
A 1 466 ARG 466 729 729 ARG ARG A . n 
A 1 467 ASN 467 730 730 ASN ASN A . n 
A 1 468 GLN 468 731 731 GLN GLN A . n 
A 1 469 ASP 469 732 732 ASP ASP A . n 
A 1 470 GLU 470 733 733 GLU GLU A . n 
A 1 471 LEU 471 734 734 LEU LEU A . n 
A 1 472 ILE 472 735 735 ILE ILE A . n 
A 1 473 GLY 473 736 736 GLY GLY A . n 
A 1 474 ARG 474 737 737 ARG ARG A . n 
A 1 475 ALA 475 738 738 ALA ALA A . n 
A 1 476 ARG 476 739 739 ARG ARG A . n 
A 1 477 ILE 477 740 740 ILE ILE A . n 
A 1 478 SER 478 741 741 SER SER A . n 
A 1 479 GLN 479 742 742 GLN GLN A . n 
A 1 480 GLY 480 743 743 GLY GLY A . n 
A 1 481 ALA 481 744 744 ALA ALA A . n 
A 1 482 GLY 482 745 745 GLY GLY A . n 
A 1 483 TRP 483 746 746 TRP TRP A . n 
A 1 484 SER 484 747 747 SER SER A . n 
A 1 485 LEU 485 748 748 LEU LEU A . n 
A 1 486 ARG 486 749 749 ARG ARG A . n 
A 1 487 GLU 487 750 750 GLU GLU A . n 
A 1 488 THR 488 751 751 THR THR A . n 
A 1 489 ALA 489 752 752 ALA ALA A . n 
A 1 490 CYS 490 753 753 CYS CYS A . n 
A 1 491 LEU 491 754 754 LEU LEU A . n 
A 1 492 GLY 492 755 755 GLY GLY A . n 
A 1 493 LYS 493 756 756 LYS LYS A . n 
A 1 494 SER 494 757 757 SER SER A . n 
A 1 495 TYR 495 758 758 TYR TYR A . n 
A 1 496 ALA 496 759 759 ALA ALA A . n 
A 1 497 GLN 497 760 760 GLN GLN A . n 
A 1 498 MET 498 761 761 MET MET A . n 
A 1 499 TRP 499 762 762 TRP TRP A . n 
A 1 500 SER 500 763 763 SER SER A . n 
A 1 501 LEU 501 764 764 LEU LEU A . n 
A 1 502 MET 502 765 765 MET MET A . n 
A 1 503 TYR 503 766 766 TYR TYR A . n 
A 1 504 PHE 504 767 767 PHE PHE A . n 
A 1 505 HIS 505 768 768 HIS HIS A . n 
A 1 506 ARG 506 769 769 ARG ARG A . n 
A 1 507 ARG 507 770 770 ARG ARG A . n 
A 1 508 ASP 508 771 771 ASP ASP A . n 
A 1 509 LEU 509 772 772 LEU LEU A . n 
A 1 510 ARG 510 773 773 ARG ARG A . n 
A 1 511 LEU 511 774 774 LEU LEU A . n 
A 1 512 ALA 512 775 775 ALA ALA A . n 
A 1 513 ALA 513 776 776 ALA ALA A . n 
A 1 514 ASN 514 777 777 ASN ASN A . n 
A 1 515 ALA 515 778 778 ALA ALA A . n 
A 1 516 ILE 516 779 779 ILE ILE A . n 
A 1 517 CYS 517 780 780 CYS CYS A . n 
A 1 518 SER 518 781 781 SER SER A . n 
A 1 519 ALA 519 782 782 ALA ALA A . n 
A 1 520 VAL 520 783 783 VAL VAL A . n 
A 1 521 PRO 521 784 784 PRO PRO A . n 
A 1 522 SER 522 785 785 SER SER A . n 
A 1 523 HIS 523 786 786 HIS HIS A . n 
A 1 524 TRP 524 787 787 TRP TRP A . n 
A 1 525 VAL 525 788 788 VAL VAL A . n 
A 1 526 PRO 526 789 789 PRO PRO A . n 
A 1 527 THR 527 790 790 THR THR A . n 
A 1 528 SER 528 791 791 SER SER A . n 
A 1 529 ARG 529 792 792 ARG ARG A . n 
A 1 530 THR 530 793 ?   ?   ?   A . n 
A 1 531 THR 531 794 ?   ?   ?   A . n 
A 1 532 TRP 532 795 ?   ?   ?   A . n 
A 1 533 SER 533 796 ?   ?   ?   A . n 
A 1 534 ILE 534 797 ?   ?   ?   A . n 
A 1 535 HIS 535 798 ?   ?   ?   A . n 
A 1 536 ALA 536 799 799 ALA ALA A . n 
A 1 537 THR 537 800 800 THR THR A . n 
A 1 538 HIS 538 801 801 HIS HIS A . n 
A 1 539 GLU 539 802 802 GLU GLU A . n 
A 1 540 TRP 540 803 803 TRP TRP A . n 
A 1 541 MET 541 804 804 MET MET A . n 
A 1 542 THR 542 805 805 THR THR A . n 
A 1 543 THR 543 806 806 THR THR A . n 
A 1 544 GLU 544 807 807 GLU GLU A . n 
A 1 545 ASP 545 808 808 ASP ASP A . n 
A 1 546 MET 546 809 809 MET MET A . n 
A 1 547 LEU 547 810 810 LEU LEU A . n 
A 1 548 THR 548 811 811 THR THR A . n 
A 1 549 VAL 549 812 812 VAL VAL A . n 
A 1 550 TRP 550 813 813 TRP TRP A . n 
A 1 551 ASN 551 814 814 ASN ASN A . n 
A 1 552 ARG 552 815 815 ARG ARG A . n 
A 1 553 VAL 553 816 816 VAL VAL A . n 
A 1 554 TRP 554 817 817 TRP TRP A . n 
A 1 555 ILE 555 818 818 ILE ILE A . n 
A 1 556 GLN 556 819 819 GLN GLN A . n 
A 1 557 GLU 557 820 820 GLU GLU A . n 
A 1 558 ASN 558 821 821 ASN ASN A . n 
A 1 559 PRO 559 822 822 PRO PRO A . n 
A 1 560 TRP 560 823 823 TRP TRP A . n 
A 1 561 MET 561 824 824 MET MET A . n 
A 1 562 GLU 562 825 825 GLU GLU A . n 
A 1 563 ASP 563 826 826 ASP ASP A . n 
A 1 564 LYS 564 827 827 LYS LYS A . n 
A 1 565 THR 565 828 828 THR THR A . n 
A 1 566 PRO 566 829 829 PRO PRO A . n 
A 1 567 VAL 567 830 830 VAL VAL A . n 
A 1 568 GLU 568 831 831 GLU GLU A . n 
A 1 569 SER 569 832 832 SER SER A . n 
A 1 570 TRP 570 833 833 TRP TRP A . n 
A 1 571 GLU 571 834 834 GLU GLU A . n 
A 1 572 GLU 572 835 835 GLU GLU A . n 
A 1 573 ILE 573 836 836 ILE ILE A . n 
A 1 574 PRO 574 837 837 PRO PRO A . n 
A 1 575 TYR 575 838 838 TYR TYR A . n 
A 1 576 LEU 576 839 839 LEU LEU A . n 
A 1 577 GLY 577 840 840 GLY GLY A . n 
A 1 578 LYS 578 841 841 LYS LYS A . n 
A 1 579 ARG 579 842 842 ARG ARG A . n 
A 1 580 GLU 580 843 843 GLU GLU A . n 
A 1 581 ASP 581 844 844 ASP ASP A . n 
A 1 582 GLN 582 845 845 GLN GLN A . n 
A 1 583 TRP 583 846 846 TRP TRP A . n 
A 1 584 CYS 584 847 847 CYS CYS A . n 
A 1 585 GLY 585 848 848 GLY GLY A . n 
A 1 586 SER 586 849 849 SER SER A . n 
A 1 587 LEU 587 850 850 LEU LEU A . n 
A 1 588 ILE 588 851 851 ILE ILE A . n 
A 1 589 GLY 589 852 852 GLY GLY A . n 
A 1 590 LEU 590 853 853 LEU LEU A . n 
A 1 591 THR 591 854 854 THR THR A . n 
A 1 592 SER 592 855 855 SER SER A . n 
A 1 593 ARG 593 856 856 ARG ARG A . n 
A 1 594 ALA 594 857 857 ALA ALA A . n 
A 1 595 THR 595 858 858 THR THR A . n 
A 1 596 TRP 596 859 859 TRP TRP A . n 
A 1 597 ALA 597 860 860 ALA ALA A . n 
A 1 598 LYS 598 861 861 LYS LYS A . n 
A 1 599 ASN 599 862 862 ASN ASN A . n 
A 1 600 ILE 600 863 863 ILE ILE A . n 
A 1 601 GLN 601 864 864 GLN GLN A . n 
A 1 602 THR 602 865 865 THR THR A . n 
A 1 603 ALA 603 866 866 ALA ALA A . n 
A 1 604 ILE 604 867 867 ILE ILE A . n 
A 1 605 ASN 605 868 868 ASN ASN A . n 
A 1 606 GLN 606 869 869 GLN GLN A . n 
A 1 607 VAL 607 870 870 VAL VAL A . n 
A 1 608 ARG 608 871 871 ARG ARG A . n 
A 1 609 SER 609 872 872 SER SER A . n 
A 1 610 LEU 610 873 873 LEU LEU A . n 
A 1 611 ILE 611 874 874 ILE ILE A . n 
A 1 612 GLY 612 875 875 GLY GLY A . n 
A 1 613 ASN 613 876 876 ASN ASN A . n 
A 1 614 GLU 614 877 877 GLU GLU A . n 
A 1 615 GLU 615 878 878 GLU GLU A . n 
A 1 616 TYR 616 879 879 TYR TYR A . n 
A 1 617 THR 617 880 880 THR THR A . n 
A 1 618 ASP 618 881 881 ASP ASP A . n 
A 1 619 TYR 619 882 882 TYR TYR A . n 
A 1 620 MET 620 883 883 MET MET A . n 
A 1 621 PRO 621 884 884 PRO PRO A . n 
A 1 622 SER 622 885 885 SER SER A . n 
A 1 623 MET 623 886 886 MET MET A . n 
A 1 624 LYS 624 887 887 LYS LYS A . n 
A 1 625 ARG 625 888 888 ARG ARG A . n 
A 1 626 PHE 626 889 889 PHE PHE A . n 
A 1 627 ARG 627 890 890 ARG ARG A . n 
A 1 628 ARG 628 891 891 ARG ARG A . n 
A 1 629 GLU 629 892 ?   ?   ?   A . n 
A 1 630 GLU 630 893 ?   ?   ?   A . n 
A 1 631 GLU 631 894 ?   ?   ?   A . n 
A 1 632 GLU 632 895 ?   ?   ?   A . n 
A 1 633 ALA 633 896 ?   ?   ?   A . n 
A 1 634 GLY 634 897 ?   ?   ?   A . n 
A 1 635 VAL 635 898 ?   ?   ?   A . n 
A 1 636 LEU 636 899 ?   ?   ?   A . n 
A 1 637 TRP 637 900 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        K6U 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   K6U 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 ZN  1   1001 1001 ZN  ZN  A . 
C 2 ZN  1   1002 1002 ZN  ZN  A . 
D 3 MES 1   1003 1004 MES MES A . 
E 4 DMS 1   1004 1530 DMS DMS A . 
F 4 DMS 1   1005 1601 DMS DMS A . 
G 4 DMS 1   1006 1602 DMS DMS A . 
H 5 PO4 1   1007 1604 PO4 PO4 A . 
I 5 PO4 1   1008 1606 PO4 PO4 A . 
J 6 PEG 1   1009 1607 PEG PEG A . 
K 7 K6U 1   1010 1707 K6U LIG A . 
L 7 K6U 1   1011 1708 K6U LIG A . 
M 8 CL  1   1012 1    CL  CL  A . 
N 9 HOH 1   1101 189  HOH HOH A . 
N 9 HOH 2   1102 70   HOH HOH A . 
N 9 HOH 3   1103 120  HOH HOH A . 
N 9 HOH 4   1104 214  HOH HOH A . 
N 9 HOH 5   1105 180  HOH HOH A . 
N 9 HOH 6   1106 465  HOH HOH A . 
N 9 HOH 7   1107 1    HOH HOH A . 
N 9 HOH 8   1108 461  HOH HOH A . 
N 9 HOH 9   1109 288  HOH HOH A . 
N 9 HOH 10  1110 319  HOH HOH A . 
N 9 HOH 11  1111 220  HOH HOH A . 
N 9 HOH 12  1112 277  HOH HOH A . 
N 9 HOH 13  1113 217  HOH HOH A . 
N 9 HOH 14  1114 165  HOH HOH A . 
N 9 HOH 15  1115 341  HOH HOH A . 
N 9 HOH 16  1116 76   HOH HOH A . 
N 9 HOH 17  1117 209  HOH HOH A . 
N 9 HOH 18  1118 52   HOH HOH A . 
N 9 HOH 19  1119 401  HOH HOH A . 
N 9 HOH 20  1120 166  HOH HOH A . 
N 9 HOH 21  1121 188  HOH HOH A . 
N 9 HOH 22  1122 122  HOH HOH A . 
N 9 HOH 23  1123 204  HOH HOH A . 
N 9 HOH 24  1124 230  HOH HOH A . 
N 9 HOH 25  1125 201  HOH HOH A . 
N 9 HOH 26  1126 177  HOH HOH A . 
N 9 HOH 27  1127 211  HOH HOH A . 
N 9 HOH 28  1128 206  HOH HOH A . 
N 9 HOH 29  1129 207  HOH HOH A . 
N 9 HOH 30  1130 292  HOH HOH A . 
N 9 HOH 31  1131 197  HOH HOH A . 
N 9 HOH 32  1132 152  HOH HOH A . 
N 9 HOH 33  1133 112  HOH HOH A . 
N 9 HOH 34  1134 276  HOH HOH A . 
N 9 HOH 35  1135 258  HOH HOH A . 
N 9 HOH 36  1136 239  HOH HOH A . 
N 9 HOH 37  1137 60   HOH HOH A . 
N 9 HOH 38  1138 251  HOH HOH A . 
N 9 HOH 39  1139 151  HOH HOH A . 
N 9 HOH 40  1140 227  HOH HOH A . 
N 9 HOH 41  1141 333  HOH HOH A . 
N 9 HOH 42  1142 320  HOH HOH A . 
N 9 HOH 43  1143 190  HOH HOH A . 
N 9 HOH 44  1144 240  HOH HOH A . 
N 9 HOH 45  1145 127  HOH HOH A . 
N 9 HOH 46  1146 191  HOH HOH A . 
N 9 HOH 47  1147 34   HOH HOH A . 
N 9 HOH 48  1148 250  HOH HOH A . 
N 9 HOH 49  1149 198  HOH HOH A . 
N 9 HOH 50  1150 176  HOH HOH A . 
N 9 HOH 51  1151 300  HOH HOH A . 
N 9 HOH 52  1152 315  HOH HOH A . 
N 9 HOH 53  1153 185  HOH HOH A . 
N 9 HOH 54  1154 303  HOH HOH A . 
N 9 HOH 55  1155 203  HOH HOH A . 
N 9 HOH 56  1156 186  HOH HOH A . 
N 9 HOH 57  1157 365  HOH HOH A . 
N 9 HOH 58  1158 243  HOH HOH A . 
N 9 HOH 59  1159 463  HOH HOH A . 
N 9 HOH 60  1160 281  HOH HOH A . 
N 9 HOH 61  1161 225  HOH HOH A . 
N 9 HOH 62  1162 236  HOH HOH A . 
N 9 HOH 63  1163 215  HOH HOH A . 
N 9 HOH 64  1164 205  HOH HOH A . 
N 9 HOH 65  1165 92   HOH HOH A . 
N 9 HOH 66  1166 196  HOH HOH A . 
N 9 HOH 67  1167 202  HOH HOH A . 
N 9 HOH 68  1168 318  HOH HOH A . 
N 9 HOH 69  1169 234  HOH HOH A . 
N 9 HOH 70  1170 213  HOH HOH A . 
N 9 HOH 71  1171 179  HOH HOH A . 
N 9 HOH 72  1172 244  HOH HOH A . 
N 9 HOH 73  1173 289  HOH HOH A . 
N 9 HOH 74  1174 278  HOH HOH A . 
N 9 HOH 75  1175 308  HOH HOH A . 
N 9 HOH 76  1176 256  HOH HOH A . 
N 9 HOH 77  1177 136  HOH HOH A . 
N 9 HOH 78  1178 226  HOH HOH A . 
N 9 HOH 79  1179 274  HOH HOH A . 
N 9 HOH 80  1180 269  HOH HOH A . 
N 9 HOH 81  1181 210  HOH HOH A . 
N 9 HOH 82  1182 262  HOH HOH A . 
N 9 HOH 83  1183 265  HOH HOH A . 
N 9 HOH 84  1184 287  HOH HOH A . 
N 9 HOH 85  1185 306  HOH HOH A . 
N 9 HOH 86  1186 363  HOH HOH A . 
N 9 HOH 87  1187 178  HOH HOH A . 
N 9 HOH 88  1188 232  HOH HOH A . 
N 9 HOH 89  1189 86   HOH HOH A . 
N 9 HOH 90  1190 309  HOH HOH A . 
N 9 HOH 91  1191 245  HOH HOH A . 
N 9 HOH 92  1192 279  HOH HOH A . 
N 9 HOH 93  1193 270  HOH HOH A . 
N 9 HOH 94  1194 254  HOH HOH A . 
N 9 HOH 95  1195 325  HOH HOH A . 
N 9 HOH 96  1196 400  HOH HOH A . 
N 9 HOH 97  1197 199  HOH HOH A . 
N 9 HOH 98  1198 32   HOH HOH A . 
N 9 HOH 99  1199 231  HOH HOH A . 
N 9 HOH 100 1200 246  HOH HOH A . 
N 9 HOH 101 1201 67   HOH HOH A . 
N 9 HOH 102 1202 187  HOH HOH A . 
N 9 HOH 103 1203 242  HOH HOH A . 
N 9 HOH 104 1204 241  HOH HOH A . 
N 9 HOH 105 1205 184  HOH HOH A . 
N 9 HOH 106 1206 260  HOH HOH A . 
N 9 HOH 107 1207 458  HOH HOH A . 
N 9 HOH 108 1208 311  HOH HOH A . 
N 9 HOH 109 1209 327  HOH HOH A . 
N 9 HOH 110 1210 222  HOH HOH A . 
N 9 HOH 111 1211 389  HOH HOH A . 
N 9 HOH 112 1212 252  HOH HOH A . 
N 9 HOH 113 1213 293  HOH HOH A . 
N 9 HOH 114 1214 467  HOH HOH A . 
N 9 HOH 115 1215 350  HOH HOH A . 
N 9 HOH 116 1216 355  HOH HOH A . 
N 9 HOH 117 1217 314  HOH HOH A . 
N 9 HOH 118 1218 200  HOH HOH A . 
N 9 HOH 119 1219 375  HOH HOH A . 
N 9 HOH 120 1220 331  HOH HOH A . 
N 9 HOH 121 1221 263  HOH HOH A . 
N 9 HOH 122 1222 3    HOH HOH A . 
N 9 HOH 123 1223 392  HOH HOH A . 
N 9 HOH 124 1224 233  HOH HOH A . 
N 9 HOH 125 1225 285  HOH HOH A . 
N 9 HOH 126 1226 366  HOH HOH A . 
N 9 HOH 127 1227 330  HOH HOH A . 
N 9 HOH 128 1228 144  HOH HOH A . 
N 9 HOH 129 1229 313  HOH HOH A . 
N 9 HOH 130 1230 372  HOH HOH A . 
N 9 HOH 131 1231 45   HOH HOH A . 
N 9 HOH 132 1232 316  HOH HOH A . 
N 9 HOH 133 1233 223  HOH HOH A . 
N 9 HOH 134 1234 255  HOH HOH A . 
N 9 HOH 135 1235 322  HOH HOH A . 
N 9 HOH 136 1236 357  HOH HOH A . 
N 9 HOH 137 1237 312  HOH HOH A . 
N 9 HOH 138 1238 338  HOH HOH A . 
N 9 HOH 139 1239 321  HOH HOH A . 
N 9 HOH 140 1240 5    HOH HOH A . 
N 9 HOH 141 1241 446  HOH HOH A . 
N 9 HOH 142 1242 369  HOH HOH A . 
N 9 HOH 143 1243 367  HOH HOH A . 
N 9 HOH 144 1244 339  HOH HOH A . 
N 9 HOH 145 1245 296  HOH HOH A . 
N 9 HOH 146 1246 82   HOH HOH A . 
N 9 HOH 147 1247 284  HOH HOH A . 
N 9 HOH 148 1248 295  HOH HOH A . 
N 9 HOH 149 1249 351  HOH HOH A . 
N 9 HOH 150 1250 238  HOH HOH A . 
N 9 HOH 151 1251 212  HOH HOH A . 
N 9 HOH 152 1252 323  HOH HOH A . 
N 9 HOH 153 1253 370  HOH HOH A . 
N 9 HOH 154 1254 378  HOH HOH A . 
N 9 HOH 155 1255 304  HOH HOH A . 
N 9 HOH 156 1256 368  HOH HOH A . 
N 9 HOH 157 1257 381  HOH HOH A . 
N 9 HOH 158 1258 290  HOH HOH A . 
N 9 HOH 159 1259 307  HOH HOH A . 
N 9 HOH 160 1260 175  HOH HOH A . 
N 9 HOH 161 1261 248  HOH HOH A . 
N 9 HOH 162 1262 148  HOH HOH A . 
N 9 HOH 163 1263 371  HOH HOH A . 
N 9 HOH 164 1264 364  HOH HOH A . 
N 9 HOH 165 1265 387  HOH HOH A . 
N 9 HOH 166 1266 352  HOH HOH A . 
N 9 HOH 167 1267 402  HOH HOH A . 
N 9 HOH 168 1268 182  HOH HOH A . 
N 9 HOH 169 1269 129  HOH HOH A . 
N 9 HOH 170 1270 326  HOH HOH A . 
N 9 HOH 171 1271 394  HOH HOH A . 
N 9 HOH 172 1272 356  HOH HOH A . 
N 9 HOH 173 1273 33   HOH HOH A . 
N 9 HOH 174 1274 462  HOH HOH A . 
N 9 HOH 175 1275 361  HOH HOH A . 
N 9 HOH 176 1276 335  HOH HOH A . 
N 9 HOH 177 1277 380  HOH HOH A . 
N 9 HOH 178 1278 344  HOH HOH A . 
N 9 HOH 179 1279 47   HOH HOH A . 
N 9 HOH 180 1280 218  HOH HOH A . 
N 9 HOH 181 1281 305  HOH HOH A . 
N 9 HOH 182 1282 91   HOH HOH A . 
N 9 HOH 183 1283 404  HOH HOH A . 
N 9 HOH 184 1284 299  HOH HOH A . 
N 9 HOH 185 1285 342  HOH HOH A . 
N 9 HOH 186 1286 399  HOH HOH A . 
N 9 HOH 187 1287 354  HOH HOH A . 
N 9 HOH 188 1288 69   HOH HOH A . 
N 9 HOH 189 1289 282  HOH HOH A . 
N 9 HOH 190 1290 362  HOH HOH A . 
N 9 HOH 191 1291 297  HOH HOH A . 
N 9 HOH 192 1292 384  HOH HOH A . 
N 9 HOH 193 1293 444  HOH HOH A . 
N 9 HOH 194 1294 391  HOH HOH A . 
N 9 HOH 195 1295 14   HOH HOH A . 
N 9 HOH 196 1296 376  HOH HOH A . 
N 9 HOH 197 1297 388  HOH HOH A . 
N 9 HOH 198 1298 283  HOH HOH A . 
N 9 HOH 199 1299 193  HOH HOH A . 
N 9 HOH 200 1300 87   HOH HOH A . 
N 9 HOH 201 1301 4    HOH HOH A . 
N 9 HOH 202 1302 374  HOH HOH A . 
N 9 HOH 203 1303 286  HOH HOH A . 
N 9 HOH 204 1304 393  HOH HOH A . 
N 9 HOH 205 1305 353  HOH HOH A . 
N 9 HOH 206 1306 416  HOH HOH A . 
N 9 HOH 207 1307 403  HOH HOH A . 
N 9 HOH 208 1308 459  HOH HOH A . 
N 9 HOH 209 1309 406  HOH HOH A . 
N 9 HOH 210 1310 379  HOH HOH A . 
N 9 HOH 211 1311 340  HOH HOH A . 
N 9 HOH 212 1312 382  HOH HOH A . 
N 9 HOH 213 1313 409  HOH HOH A . 
N 9 HOH 214 1314 373  HOH HOH A . 
N 9 HOH 215 1315 422  HOH HOH A . 
N 9 HOH 216 1316 44   HOH HOH A . 
N 9 HOH 217 1317 328  HOH HOH A . 
N 9 HOH 218 1318 62   HOH HOH A . 
N 9 HOH 219 1319 349  HOH HOH A . 
N 9 HOH 220 1320 228  HOH HOH A . 
N 9 HOH 221 1321 423  HOH HOH A . 
N 9 HOH 222 1322 15   HOH HOH A . 
N 9 HOH 223 1323 360  HOH HOH A . 
N 9 HOH 224 1324 386  HOH HOH A . 
N 9 HOH 225 1325 359  HOH HOH A . 
N 9 HOH 226 1326 383  HOH HOH A . 
N 9 HOH 227 1327 411  HOH HOH A . 
N 9 HOH 228 1328 50   HOH HOH A . 
N 9 HOH 229 1329 28   HOH HOH A . 
N 9 HOH 230 1330 104  HOH HOH A . 
N 9 HOH 231 1331 398  HOH HOH A . 
N 9 HOH 232 1332 427  HOH HOH A . 
N 9 HOH 233 1333 412  HOH HOH A . 
N 9 HOH 234 1334 466  HOH HOH A . 
N 9 HOH 235 1335 56   HOH HOH A . 
N 9 HOH 236 1336 347  HOH HOH A . 
N 9 HOH 237 1337 418  HOH HOH A . 
N 9 HOH 238 1338 128  HOH HOH A . 
N 9 HOH 239 1339 390  HOH HOH A . 
N 9 HOH 240 1340 99   HOH HOH A . 
N 9 HOH 241 1341 18   HOH HOH A . 
N 9 HOH 242 1342 132  HOH HOH A . 
N 9 HOH 243 1343 452  HOH HOH A . 
N 9 HOH 244 1344 410  HOH HOH A . 
N 9 HOH 245 1345 146  HOH HOH A . 
N 9 HOH 246 1346 438  HOH HOH A . 
N 9 HOH 247 1347 72   HOH HOH A . 
N 9 HOH 248 1348 415  HOH HOH A . 
N 9 HOH 249 1349 431  HOH HOH A . 
N 9 HOH 250 1350 324  HOH HOH A . 
N 9 HOH 251 1351 439  HOH HOH A . 
N 9 HOH 252 1352 414  HOH HOH A . 
N 9 HOH 253 1353 432  HOH HOH A . 
N 9 HOH 254 1354 43   HOH HOH A . 
N 9 HOH 255 1355 123  HOH HOH A . 
N 9 HOH 256 1356 59   HOH HOH A . 
N 9 HOH 257 1357 437  HOH HOH A . 
N 9 HOH 258 1358 430  HOH HOH A . 
N 9 HOH 259 1359 424  HOH HOH A . 
N 9 HOH 260 1360 434  HOH HOH A . 
N 9 HOH 261 1361 159  HOH HOH A . 
N 9 HOH 262 1362 428  HOH HOH A . 
N 9 HOH 263 1363 332  HOH HOH A . 
N 9 HOH 264 1364 126  HOH HOH A . 
N 9 HOH 265 1365 425  HOH HOH A . 
N 9 HOH 266 1366 54   HOH HOH A . 
N 9 HOH 267 1367 436  HOH HOH A . 
N 9 HOH 268 1368 435  HOH HOH A . 
N 9 HOH 269 1369 420  HOH HOH A . 
N 9 HOH 270 1370 124  HOH HOH A . 
N 9 HOH 271 1371 131  HOH HOH A . 
N 9 HOH 272 1372 63   HOH HOH A . 
N 9 HOH 273 1373 329  HOH HOH A . 
N 9 HOH 274 1374 53   HOH HOH A . 
N 9 HOH 275 1375 181  HOH HOH A . 
N 9 HOH 276 1376 93   HOH HOH A . 
N 9 HOH 277 1377 88   HOH HOH A . 
N 9 HOH 278 1378 426  HOH HOH A . 
N 9 HOH 279 1379 172  HOH HOH A . 
N 9 HOH 280 1380 464  HOH HOH A . 
N 9 HOH 281 1381 301  HOH HOH A . 
N 9 HOH 282 1382 78   HOH HOH A . 
N 9 HOH 283 1383 61   HOH HOH A . 
N 9 HOH 284 1384 40   HOH HOH A . 
N 9 HOH 285 1385 171  HOH HOH A . 
N 9 HOH 286 1386 449  HOH HOH A . 
N 9 HOH 287 1387 121  HOH HOH A . 
N 9 HOH 288 1388 445  HOH HOH A . 
N 9 HOH 289 1389 8    HOH HOH A . 
N 9 HOH 290 1390 441  HOH HOH A . 
N 9 HOH 291 1391 64   HOH HOH A . 
N 9 HOH 292 1392 162  HOH HOH A . 
N 9 HOH 293 1393 55   HOH HOH A . 
N 9 HOH 294 1394 455  HOH HOH A . 
N 9 HOH 295 1395 440  HOH HOH A . 
N 9 HOH 296 1396 443  HOH HOH A . 
N 9 HOH 297 1397 447  HOH HOH A . 
N 9 HOH 298 1398 448  HOH HOH A . 
N 9 HOH 299 1399 453  HOH HOH A . 
N 9 HOH 300 1400 95   HOH HOH A . 
N 9 HOH 301 1401 9    HOH HOH A . 
N 9 HOH 302 1402 130  HOH HOH A . 
N 9 HOH 303 1403 49   HOH HOH A . 
N 9 HOH 304 1404 73   HOH HOH A . 
N 9 HOH 305 1405 450  HOH HOH A . 
N 9 HOH 306 1406 156  HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A THR 344 ? CB  ? A THR 81 CB  
2 1 Y 1 A THR 344 ? OG1 ? A THR 81 OG1 
3 1 Y 1 A THR 344 ? CG2 ? A THR 81 CG2 
# 
loop_
_software.classification 
_software.name 
_software.version 
_software.citation_id 
_software.pdbx_ordinal 
_software.date 
_software.type 
_software.location 
_software.language 
refinement       REFMAC  5.8.0267 ? 1 ? ? ? ? 
'data scaling'   Aimless .        ? 2 ? ? ? ? 
phasing          PHASER  .        ? 3 ? ? ? ? 
'data reduction' XDS     .        ? 4 ? ? ? ? 
# 
_cell.entry_id           7I2H 
_cell.length_a           82.375 
_cell.length_b           115.505 
_cell.length_c           146.633 
_cell.angle_alpha        90.00 
_cell.angle_beta         90.00 
_cell.angle_gamma        90.00 
_cell.Z_PDB              8 
_cell.pdbx_unique_axis   ? 
# 
_symmetry.entry_id                         7I2H 
_symmetry.space_group_name_H-M             'I 2 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                23 
# 
_exptl.entry_id          7I2H 
_exptl.method            'X-RAY DIFFRACTION' 
_exptl.crystals_number   1 
# 
_exptl_crystal.id                    1 
_exptl_crystal.density_meas          ? 
_exptl_crystal.density_Matthews      2.36 
_exptl_crystal.density_percent_sol   47.89 
_exptl_crystal.description           ? 
_exptl_crystal.preparation           ? 
# 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.temp            293.15 
_exptl_crystal_grow.pdbx_details    '350 mM Magnesium chloride, 10% PEG 4000, 100 mM MES, pH 6.5' 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.pdbx_pH_range   ? 
# 
_diffrn.id                               1 
_diffrn.ambient_temp                     100 
_diffrn.crystal_id                       1 
_diffrn.ambient_temp_details             ? 
_diffrn.pdbx_serial_crystal_experiment   ? 
# 
_diffrn_detector.detector               PIXEL 
_diffrn_detector.type                   'DECTRIS EIGER2 XE 9M' 
_diffrn_detector.pdbx_collection_date   2023-12-03 
_diffrn_detector.diffrn_id              1 
_diffrn_detector.details                ? 
# 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.92124 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.diffrn_id                   1 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.type                        'DIAMOND BEAMLINE I04-1' 
_diffrn_source.pdbx_wavelength_list        0.92124 
_diffrn_source.pdbx_synchrotron_site       Diamond 
_diffrn_source.pdbx_synchrotron_beamline   I04-1 
_diffrn_source.pdbx_wavelength             ? 
# 
_reflns.entry_id                     7I2H 
_reflns.pdbx_diffrn_id               1 
_reflns.pdbx_ordinal                 1 
_reflns.d_resolution_low             37.50 
_reflns.d_resolution_high            1.84 
_reflns.number_obs                   60872 
_reflns.percent_possible_obs         100.0 
_reflns.pdbx_Rmerge_I_obs            0.179 
_reflns.pdbx_netI_over_sigmaI        7.8 
_reflns.pdbx_redundancy              13.7 
_reflns.pdbx_Rrim_I_all              0.186 
_reflns.pdbx_Rpim_I_all              0.050 
_reflns.pdbx_CC_half                 0.998 
_reflns.pdbx_number_measured_all     832493 
_reflns.pdbx_chi_squared             0.35 
_reflns.observed_criterion_sigma_I   ? 
_reflns.observed_criterion_sigma_F   ? 
_reflns.number_all                   ? 
_reflns.pdbx_Rsym_value              ? 
_reflns.B_iso_Wilson_estimate        ? 
_reflns.pdbx_CC_star                 ? 
# 
_reflns_shell.pdbx_diffrn_id              1 
_reflns_shell.pdbx_ordinal                1 
_reflns_shell.d_res_high                  1.84 
_reflns_shell.d_res_low                   1.88 
_reflns_shell.number_measured_all         51698 
_reflns_shell.number_unique_obs           3722 
_reflns_shell.Rmerge_I_obs                5.225 
_reflns_shell.pdbx_chi_squared            0.15 
_reflns_shell.pdbx_redundancy             13.9 
_reflns_shell.percent_possible_obs        99.5 
_reflns_shell.pdbx_netI_over_sigmaI_obs   0.3 
_reflns_shell.pdbx_Rrim_I_all             5.423 
_reflns_shell.pdbx_Rpim_I_all             1.446 
_reflns_shell.pdbx_CC_half                0.360 
_reflns_shell.percent_possible_all        ? 
_reflns_shell.pdbx_Rsym_value             ? 
_reflns_shell.meanI_over_sigI_obs         ? 
_reflns_shell.number_measured_obs         ? 
_reflns_shell.number_unique_all           ? 
_reflns_shell.pdbx_CC_star                ? 
# 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.entry_id                                 7I2H 
_refine.pdbx_diffrn_id                           1 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     55272 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             37.5 
_refine.ls_d_res_high                            1.84 
_refine.ls_percent_reflns_obs                    95.65 
_refine.ls_R_factor_obs                          0.20510 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       0.20292 
_refine.ls_R_factor_R_free                       0.24386 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 5.2 
_refine.ls_number_reflns_R_free                  3011 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               0.964 
_refine.correlation_coeff_Fo_to_Fc_free          0.951 
_refine.B_iso_mean                               65.515 
_refine.aniso_B[1][1]                            -3.35 
_refine.aniso_B[2][2]                            0.75 
_refine.aniso_B[3][3]                            2.60 
_refine.aniso_B[1][2]                            -0.00 
_refine.aniso_B[1][3]                            0.00 
_refine.aniso_B[2][3]                            -0.00 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_overall_ESU_R                       0.309 
_refine.pdbx_overall_ESU_R_Free                  0.197 
_refine.overall_SU_ML                            0.278 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             11.169 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.pdbx_number_atoms_protein        4636 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         70 
_refine_hist.number_atoms_solvent             306 
_refine_hist.number_atoms_total               5012 
_refine_hist.d_res_high                       1.84 
_refine_hist.d_res_low                        37.5 
# 
loop_
_refine_ls_restr.type 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.weight 
_refine_ls_restr.number 
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.pdbx_restraint_function 
r_bond_refined_d             0.006  0.015  ? 13138 'X-RAY DIFFRACTION' ? 
r_bond_other_d               0.001  0.015  ? 8886  'X-RAY DIFFRACTION' ? 
r_angle_refined_deg          1.392  1.642  ? 13037 'X-RAY DIFFRACTION' ? 
r_angle_other_deg            1.187  1.592  ? 20524 'X-RAY DIFFRACTION' ? 
r_dihedral_angle_1_deg       6.043  5.000  ? 1208  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_2_deg       30.914 20.868 ? 576   'X-RAY DIFFRACTION' ? 
r_dihedral_angle_3_deg       15.896 15.000 ? 1743  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_4_deg       17.630 15.000 ? 98    'X-RAY DIFFRACTION' ? 
r_chiral_restr               0.059  0.200  ? 1162  'X-RAY DIFFRACTION' ? 
r_gen_planes_refined         0.006  0.020  ? 11471 'X-RAY DIFFRACTION' ? 
r_gen_planes_other           0.001  0.020  ? 2449  'X-RAY DIFFRACTION' ? 
r_nbd_refined                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbd_other                  ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_refined              ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_other                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_refined        ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_other          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_refined          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_other            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_refined       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_other         ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_refined     ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_other       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_refined ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_other   ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_mcbond_it                  3.141  6.551  ? 6315  'X-RAY DIFFRACTION' ? 
r_mcbond_other               3.192  6.564  ? 6112  'X-RAY DIFFRACTION' ? 
r_mcangle_it                 5.861  9.444  ? 5832  'X-RAY DIFFRACTION' ? 
r_mcangle_other              5.861  9.444  ? 5833  'X-RAY DIFFRACTION' ? 
r_scbond_it                  3.367  7.312  ? 6823  'X-RAY DIFFRACTION' ? 
r_scbond_other               3.368  7.314  ? 6819  'X-RAY DIFFRACTION' ? 
r_scangle_it                 ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_scangle_other              5.912  10.498 ? 7206  'X-RAY DIFFRACTION' ? 
r_long_range_B_refined       10.258 67.960 ? 10769 'X-RAY DIFFRACTION' ? 
r_long_range_B_other         10.079 67.768 ? 10613 'X-RAY DIFFRACTION' ? 
r_rigid_bond_restr           ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_free            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_bonded          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.d_res_high                       1.840 
_refine_ls_shell.d_res_low                        1.888 
_refine_ls_shell.number_reflns_R_work             2195 
_refine_ls_shell.R_factor_R_work                  0.486 
_refine_ls_shell.percent_reflns_obs               51.30 
_refine_ls_shell.R_factor_R_free                  0.529 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.number_reflns_R_free             118 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.number_reflns_obs                ? 
# 
_struct.entry_id                  7I2H 
_struct.title                     
;Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z1198177230 (DNV2_NS5A-x0411)
;
_struct.pdbx_model_details        ? 
_struct.pdbx_CASP_flag            ? 
_struct.pdbx_model_type_details   ? 
# 
_struct_keywords.entry_id        7I2H 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
_struct_keywords.text            
;Diamond Light Source, I04-1, READDI, Dengue Virus, crystallographic fragment screening, PanDDA, XChemExplorer, cluster4x, VIRAL PROTEIN
;
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 4 ? 
H N N 5 ? 
I N N 5 ? 
J N N 6 ? 
K N N 7 ? 
L N N 7 ? 
M N N 8 ? 
N N N 9 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q91H74_9FLAV 
_struct_ref.pdbx_db_accession          Q91H74 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;GIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAMTD
TTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAREA
VEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLS
GVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRPTP
RGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGDDC
VVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQGAG
WSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPWME
DKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_struct_ref.pdbx_align_begin           2757 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              7I2H 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 3 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 637 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q91H74 
_struct_ref_seq.db_align_beg                  2757 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3391 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       266 
_struct_ref_seq.pdbx_auth_seq_align_end       900 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 7I2H GLY A 1 ? UNP Q91H74 ? ? 'expression tag' 264 1 
1 7I2H PRO A 2 ? UNP Q91H74 ? ? 'expression tag' 265 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 10  ? HIS A 25  ? ASN A 273 HIS A 288 1 ? 16 
HELX_P HELX_P2  AA2 ASN A 59  ? LEU A 65  ? ASN A 322 LEU A 328 1 ? 7  
HELX_P HELX_P3  AA3 THR A 66  ? ILE A 71  ? THR A 329 ILE A 334 5 ? 6  
HELX_P HELX_P4  AA4 ILE A 72  ? GLN A 77  ? ILE A 335 GLN A 340 1 ? 6  
HELX_P HELX_P5  AA5 MET A 78  ? MET A 80  ? MET A 341 MET A 343 5 ? 3  
HELX_P HELX_P6  AA6 LYS A 104 ? GLY A 123 ? LYS A 367 GLY A 386 1 ? 20 
HELX_P HELX_P7  AA7 LYS A 124 ? LYS A 126 ? LYS A 387 LYS A 389 5 ? 3  
HELX_P HELX_P8  AA8 THR A 132 ? ARG A 141 ? THR A 395 ARG A 404 1 ? 10 
HELX_P HELX_P9  AA9 SER A 158 ? VAL A 163 ? SER A 421 VAL A 426 1 ? 6  
HELX_P HELX_P10 AB1 ASP A 165 ? GLU A 181 ? ASP A 428 GLU A 444 1 ? 17 
HELX_P HELX_P11 AB2 TRP A 215 ? GLY A 227 ? TRP A 478 GLY A 490 1 ? 13 
HELX_P HELX_P12 AB3 GLY A 227 ? ASP A 232 ? GLY A 490 ASP A 495 1 ? 6  
HELX_P HELX_P13 AB4 SER A 236 ? LEU A 241 ? SER A 499 LEU A 504 1 ? 6  
HELX_P HELX_P14 AB5 GLY A 248 ? LYS A 261 ? GLY A 511 LYS A 524 1 ? 14 
HELX_P HELX_P15 AB6 GLY A 274 ? ILE A 279 ? GLY A 537 ILE A 542 5 ? 6  
HELX_P HELX_P16 AB7 THR A 280 ? MET A 289 ? THR A 543 MET A 552 1 ? 10 
HELX_P HELX_P17 AB8 VAL A 290 ? MET A 294 ? VAL A 553 MET A 557 5 ? 5  
HELX_P HELX_P18 AB9 GLU A 295 ? THR A 309 ? GLU A 558 THR A 572 1 ? 15 
HELX_P HELX_P19 AC1 VAL A 342 ? GLU A 363 ? VAL A 605 GLU A 626 1 ? 22 
HELX_P HELX_P20 AC2 THR A 373 ? SER A 393 ? THR A 636 SER A 656 1 ? 21 
HELX_P HELX_P21 AC3 ASP A 408 ? ALA A 414 ? ASP A 671 ALA A 677 5 ? 7  
HELX_P HELX_P22 AC4 LEU A 415 ? MET A 421 ? LEU A 678 MET A 684 1 ? 7  
HELX_P HELX_P23 AC5 ASN A 467 ? ARG A 476 ? ASN A 730 ARG A 739 1 ? 10 
HELX_P HELX_P24 AC6 SER A 484 ? TYR A 503 ? SER A 747 TYR A 766 1 ? 20 
HELX_P HELX_P25 AC7 ARG A 506 ? VAL A 520 ? ARG A 769 VAL A 783 1 ? 15 
HELX_P HELX_P26 AC8 ASP A 545 ? ILE A 555 ? ASP A 808 ILE A 818 1 ? 11 
HELX_P HELX_P27 AC9 SER A 569 ? ILE A 573 ? SER A 832 ILE A 836 5 ? 5  
HELX_P HELX_P28 AD1 GLY A 577 ? CYS A 584 ? GLY A 840 CYS A 847 1 ? 8  
HELX_P HELX_P29 AD2 LEU A 590 ? ASN A 599 ? LEU A 853 ASN A 862 1 ? 10 
HELX_P HELX_P30 AD3 ASN A 599 ? GLY A 612 ? ASN A 862 GLY A 875 1 ? 14 
HELX_P HELX_P31 AD4 TYR A 619 ? MET A 623 ? TYR A 882 MET A 886 5 ? 5  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A GLU 175 OE1 ? ? ? 1_555 C ZN . ZN ? ? A GLU 438 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.069 ? ? 
metalc2 metalc ? ? A HIS 179 NE2 ? ? ? 1_555 C ZN . ZN ? ? A HIS 442 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.108 ? ? 
metalc3 metalc ? ? A CYS 184 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 447 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.324 ? ? 
metalc4 metalc ? ? A CYS 187 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 450 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.550 ? ? 
metalc5 metalc ? ? A HIS 449 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 712 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.010 ? ? 
metalc6 metalc ? ? A HIS 451 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 714 A ZN 1001 1_555 ? ? ? ? ? ? ? 1.969 ? ? 
metalc7 metalc ? ? A CYS 465 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 728 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.401 ? ? 
metalc8 metalc ? ? A CYS 584 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 847 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.335 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 NE2 ? A HIS 179 ? A HIS 442 ? 1_555 99.8  ? 
2  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 127.2 ? 
3  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 122.6 ? 
4  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 79.7  ? 
5  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 107.5 ? 
6  SG  ? A CYS 184 ? A CYS 447 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 111.2 ? 
7  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 100.1 ? 
8  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 106.5 ? 
9  NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 107.4 ? 
10 NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 105.0 ? 
11 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 119.3 ? 
12 SG  ? A CYS 465 ? A CYS 728 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 116.5 ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 41  ? GLY A 44  ? ALA A 304 GLY A 307 
AA1 2 VAL A 326 ? ARG A 332 ? VAL A 589 ARG A 595 
AA1 3 LYS A 313 ? ARG A 319 ? LYS A 576 ARG A 582 
AA1 4 TYR A 189 ? ASN A 190 ? TYR A 452 ASN A 453 
AA2 1 MET A 57  ? VAL A 58  ? MET A 320 VAL A 321 
AA2 2 ILE A 477 ? SER A 478 ? ILE A 740 SER A 741 
AA3 1 MET A 395 ? SER A 398 ? MET A 658 SER A 661 
AA3 2 ASP A 401 ? VAL A 404 ? ASP A 664 VAL A 667 
AA4 1 HIS A 449 ? ILE A 454 ? HIS A 712 ILE A 717 
AA4 2 VAL A 460 ? CYS A 465 ? VAL A 723 CYS A 728 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N HIS A 43  ? N HIS A 306 O ILE A 329 ? O ILE A 592 
AA1 2 3 O ARG A 332 ? O ARG A 595 N LYS A 313 ? N LYS A 576 
AA1 3 4 O VAL A 314 ? O VAL A 577 N TYR A 189 ? N TYR A 452 
AA2 1 2 N MET A 57  ? N MET A 320 O SER A 478 ? O SER A 741 
AA3 1 2 N SER A 398 ? N SER A 661 O ASP A 401 ? O ASP A 664 
AA4 1 2 N HIS A 449 ? N HIS A 712 O CYS A 465 ? O CYS A 728 
# 
_pdbx_entry_details.entry_id                   7I2H 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 OD1 A ASP 664 ? ? O4 A PO4 1007 ? ? 2.06 
2 1 OD1 A ASP 534 ? ? O4 A PO4 1007 ? ? 2.18 
# 
loop_
_pdbx_validate_symm_contact.id 
_pdbx_validate_symm_contact.PDB_model_num 
_pdbx_validate_symm_contact.auth_atom_id_1 
_pdbx_validate_symm_contact.auth_asym_id_1 
_pdbx_validate_symm_contact.auth_comp_id_1 
_pdbx_validate_symm_contact.auth_seq_id_1 
_pdbx_validate_symm_contact.PDB_ins_code_1 
_pdbx_validate_symm_contact.label_alt_id_1 
_pdbx_validate_symm_contact.site_symmetry_1 
_pdbx_validate_symm_contact.auth_atom_id_2 
_pdbx_validate_symm_contact.auth_asym_id_2 
_pdbx_validate_symm_contact.auth_comp_id_2 
_pdbx_validate_symm_contact.auth_seq_id_2 
_pdbx_validate_symm_contact.PDB_ins_code_2 
_pdbx_validate_symm_contact.label_alt_id_2 
_pdbx_validate_symm_contact.site_symmetry_2 
_pdbx_validate_symm_contact.dist 
1 1 O A HOH 1105 ? ? 1_555 O A HOH 1105 ? ? 2_445 1.75 
2 1 O A HOH 1251 ? ? 1_555 O A HOH 1368 ? ? 2_445 2.09 
3 1 O A HOH 1247 ? ? 1_555 O A HOH 1344 ? ? 2_545 2.18 
# 
_pdbx_validate_rmsd_bond.id                        1 
_pdbx_validate_rmsd_bond.PDB_model_num             1 
_pdbx_validate_rmsd_bond.auth_atom_id_1            CD 
_pdbx_validate_rmsd_bond.auth_asym_id_1            A 
_pdbx_validate_rmsd_bond.auth_comp_id_1            GLU 
_pdbx_validate_rmsd_bond.auth_seq_id_1             510 
_pdbx_validate_rmsd_bond.PDB_ins_code_1            ? 
_pdbx_validate_rmsd_bond.label_alt_id_1            ? 
_pdbx_validate_rmsd_bond.auth_atom_id_2            OE2 
_pdbx_validate_rmsd_bond.auth_asym_id_2            A 
_pdbx_validate_rmsd_bond.auth_comp_id_2            GLU 
_pdbx_validate_rmsd_bond.auth_seq_id_2             510 
_pdbx_validate_rmsd_bond.PDB_ins_code_2            ? 
_pdbx_validate_rmsd_bond.label_alt_id_2            ? 
_pdbx_validate_rmsd_bond.bond_value                1.326 
_pdbx_validate_rmsd_bond.bond_target_value         1.252 
_pdbx_validate_rmsd_bond.bond_deviation            0.074 
_pdbx_validate_rmsd_bond.bond_standard_deviation   0.011 
_pdbx_validate_rmsd_bond.linker_flag               N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 ASP A 297 ? ? -103.97 74.71   
2  1 ASN A 406 ? ? 45.83   70.87   
3  1 LEU A 504 ? ? 74.41   -37.09  
4  1 GLN A 598 ? ? 66.71   163.73  
5  1 SER A 601 ? ? -106.17 -157.46 
6  1 LYS A 719 ? A -39.50  -34.11  
7  1 SER A 791 ? ? -171.45 112.45  
8  1 HIS A 801 ? A -119.43 63.02   
9  1 HIS A 801 ? B -117.22 62.17   
10 1 PRO A 884 ? ? -59.08  -9.75   
11 1 ARG A 890 ? ? -64.58  45.33   
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A MES 1003 ? D MES . 
2 1 A HOH 1127 ? N HOH . 
3 1 A HOH 1199 ? N HOH . 
4 1 A HOH 1346 ? N HOH . 
5 1 A HOH 1363 ? N HOH . 
6 1 A HOH 1406 ? N HOH . 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 1404 ? 6.12 . 
2 1 O ? A HOH 1405 ? 6.55 . 
3 1 O ? A HOH 1406 ? 6.99 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 264 ? A GLY 1   
2  1 Y 1 A PRO 265 ? A PRO 2   
3  1 Y 1 A GLY 266 ? A GLY 3   
4  1 Y 1 A ILE 267 ? A ILE 4   
5  1 Y 1 A GLU 268 ? A GLU 5   
6  1 Y 1 A SER 269 ? A SER 6   
7  1 Y 1 A GLU 270 ? A GLU 7   
8  1 Y 1 A THR 271 ? A THR 8   
9  1 Y 1 A PRO 272 ? A PRO 9   
10 1 Y 1 A LYS 312 ? A LYS 49  
11 1 Y 1 A GLN 313 ? A GLN 50  
12 1 Y 1 A THR 314 ? A THR 51  
13 1 Y 1 A GLY 315 ? A GLY 52  
14 1 Y 1 A SER 316 ? A SER 53  
15 1 Y 1 A ALA 317 ? A ALA 54  
16 1 Y 1 A SER 318 ? A SER 55  
17 1 Y 1 A ASP 345 ? A ASP 82  
18 1 Y 1 A THR 346 ? A THR 83  
19 1 Y 1 A THR 347 ? A THR 84  
20 1 Y 1 A PRO 348 ? A PRO 85  
21 1 Y 1 A PHE 349 ? A PHE 86  
22 1 Y 1 A GLY 350 ? A GLY 87  
23 1 Y 1 A GLN 351 ? A GLN 88  
24 1 Y 1 A GLN 352 ? A GLN 89  
25 1 Y 1 A ARG 353 ? A ARG 90  
26 1 Y 1 A VAL 354 ? A VAL 91  
27 1 Y 1 A PHE 355 ? A PHE 92  
28 1 Y 1 A LYS 356 ? A LYS 93  
29 1 Y 1 A ILE 412 ? A ILE 149 
30 1 Y 1 A PHE 413 ? A PHE 150 
31 1 Y 1 A THR 414 ? A THR 151 
32 1 Y 1 A ASP 415 ? A ASP 152 
33 1 Y 1 A GLU 416 ? A GLU 153 
34 1 Y 1 A ASN 417 ? A ASN 154 
35 1 Y 1 A LYS 418 ? A LYS 155 
36 1 Y 1 A GLY 456 ? A GLY 193 
37 1 Y 1 A LYS 457 ? A LYS 194 
38 1 Y 1 A ARG 458 ? A ARG 195 
39 1 Y 1 A GLU 459 ? A GLU 196 
40 1 Y 1 A LYS 460 ? A LYS 197 
41 1 Y 1 A LYS 461 ? A LYS 198 
42 1 Y 1 A LEU 462 ? A LEU 199 
43 1 Y 1 A GLY 463 ? A GLY 200 
44 1 Y 1 A GLU 464 ? A GLU 201 
45 1 Y 1 A PHE 465 ? A PHE 202 
46 1 Y 1 A GLY 466 ? A GLY 203 
47 1 Y 1 A LYS 467 ? A LYS 204 
48 1 Y 1 A ALA 468 ? A ALA 205 
49 1 Y 1 A LYS 469 ? A LYS 206 
50 1 Y 1 A GLY 470 ? A GLY 207 
51 1 Y 1 A SER 471 ? A SER 208 
52 1 Y 1 A ARG 472 ? A ARG 209 
53 1 Y 1 A PRO 585 ? A PRO 322 
54 1 Y 1 A ARG 586 ? A ARG 323 
55 1 Y 1 A GLY 587 ? A GLY 324 
56 1 Y 1 A THR 793 ? A THR 530 
57 1 Y 1 A THR 794 ? A THR 531 
58 1 Y 1 A TRP 795 ? A TRP 532 
59 1 Y 1 A SER 796 ? A SER 533 
60 1 Y 1 A ILE 797 ? A ILE 534 
61 1 Y 1 A HIS 798 ? A HIS 535 
62 1 Y 1 A GLU 892 ? A GLU 629 
63 1 Y 1 A GLU 893 ? A GLU 630 
64 1 Y 1 A GLU 894 ? A GLU 631 
65 1 Y 1 A GLU 895 ? A GLU 632 
66 1 Y 1 A ALA 896 ? A ALA 633 
67 1 Y 1 A GLY 897 ? A GLY 634 
68 1 Y 1 A VAL 898 ? A VAL 635 
69 1 Y 1 A LEU 899 ? A LEU 636 
70 1 Y 1 A TRP 900 ? A TRP 637 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CL  CL   CL N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
DMS S    S  N N 89  
DMS O    O  N N 90  
DMS C1   C  N N 91  
DMS C2   C  N N 92  
DMS H11  H  N N 93  
DMS H12  H  N N 94  
DMS H13  H  N N 95  
DMS H21  H  N N 96  
DMS H22  H  N N 97  
DMS H23  H  N N 98  
GLN N    N  N N 99  
GLN CA   C  N S 100 
GLN C    C  N N 101 
GLN O    O  N N 102 
GLN CB   C  N N 103 
GLN CG   C  N N 104 
GLN CD   C  N N 105 
GLN OE1  O  N N 106 
GLN NE2  N  N N 107 
GLN OXT  O  N N 108 
GLN H    H  N N 109 
GLN H2   H  N N 110 
GLN HA   H  N N 111 
GLN HB2  H  N N 112 
GLN HB3  H  N N 113 
GLN HG2  H  N N 114 
GLN HG3  H  N N 115 
GLN HE21 H  N N 116 
GLN HE22 H  N N 117 
GLN HXT  H  N N 118 
GLU N    N  N N 119 
GLU CA   C  N S 120 
GLU C    C  N N 121 
GLU O    O  N N 122 
GLU CB   C  N N 123 
GLU CG   C  N N 124 
GLU CD   C  N N 125 
GLU OE1  O  N N 126 
GLU OE2  O  N N 127 
GLU OXT  O  N N 128 
GLU H    H  N N 129 
GLU H2   H  N N 130 
GLU HA   H  N N 131 
GLU HB2  H  N N 132 
GLU HB3  H  N N 133 
GLU HG2  H  N N 134 
GLU HG3  H  N N 135 
GLU HE2  H  N N 136 
GLU HXT  H  N N 137 
GLY N    N  N N 138 
GLY CA   C  N N 139 
GLY C    C  N N 140 
GLY O    O  N N 141 
GLY OXT  O  N N 142 
GLY H    H  N N 143 
GLY H2   H  N N 144 
GLY HA2  H  N N 145 
GLY HA3  H  N N 146 
GLY HXT  H  N N 147 
HIS N    N  N N 148 
HIS CA   C  N S 149 
HIS C    C  N N 150 
HIS O    O  N N 151 
HIS CB   C  N N 152 
HIS CG   C  Y N 153 
HIS ND1  N  Y N 154 
HIS CD2  C  Y N 155 
HIS CE1  C  Y N 156 
HIS NE2  N  Y N 157 
HIS OXT  O  N N 158 
HIS H    H  N N 159 
HIS H2   H  N N 160 
HIS HA   H  N N 161 
HIS HB2  H  N N 162 
HIS HB3  H  N N 163 
HIS HD1  H  N N 164 
HIS HD2  H  N N 165 
HIS HE1  H  N N 166 
HIS HE2  H  N N 167 
HIS HXT  H  N N 168 
HOH O    O  N N 169 
HOH H1   H  N N 170 
HOH H2   H  N N 171 
ILE N    N  N N 172 
ILE CA   C  N S 173 
ILE C    C  N N 174 
ILE O    O  N N 175 
ILE CB   C  N S 176 
ILE CG1  C  N N 177 
ILE CG2  C  N N 178 
ILE CD1  C  N N 179 
ILE OXT  O  N N 180 
ILE H    H  N N 181 
ILE H2   H  N N 182 
ILE HA   H  N N 183 
ILE HB   H  N N 184 
ILE HG12 H  N N 185 
ILE HG13 H  N N 186 
ILE HG21 H  N N 187 
ILE HG22 H  N N 188 
ILE HG23 H  N N 189 
ILE HD11 H  N N 190 
ILE HD12 H  N N 191 
ILE HD13 H  N N 192 
ILE HXT  H  N N 193 
K6U N1   N  Y N 194 
K6U C4   C  Y N 195 
K6U C5   C  Y N 196 
K6U C6   C  Y N 197 
K6U C7   C  Y N 198 
K6U C8   C  Y N 199 
K6U C1   C  N N 200 
K6U C2   C  Y N 201 
K6U C3   C  Y N 202 
K6U C9   C  Y N 203 
K6U N2   N  Y N 204 
K6U O1   O  N N 205 
K6U O2   O  Y N 206 
K6U H5   H  N N 207 
K6U H6   H  N N 208 
K6U H7   H  N N 209 
K6U H3   H  N N 210 
K6U H2   H  N N 211 
K6U H1   H  N N 212 
K6U H4   H  N N 213 
K6U H8   H  N N 214 
LEU N    N  N N 215 
LEU CA   C  N S 216 
LEU C    C  N N 217 
LEU O    O  N N 218 
LEU CB   C  N N 219 
LEU CG   C  N N 220 
LEU CD1  C  N N 221 
LEU CD2  C  N N 222 
LEU OXT  O  N N 223 
LEU H    H  N N 224 
LEU H2   H  N N 225 
LEU HA   H  N N 226 
LEU HB2  H  N N 227 
LEU HB3  H  N N 228 
LEU HG   H  N N 229 
LEU HD11 H  N N 230 
LEU HD12 H  N N 231 
LEU HD13 H  N N 232 
LEU HD21 H  N N 233 
LEU HD22 H  N N 234 
LEU HD23 H  N N 235 
LEU HXT  H  N N 236 
LYS N    N  N N 237 
LYS CA   C  N S 238 
LYS C    C  N N 239 
LYS O    O  N N 240 
LYS CB   C  N N 241 
LYS CG   C  N N 242 
LYS CD   C  N N 243 
LYS CE   C  N N 244 
LYS NZ   N  N N 245 
LYS OXT  O  N N 246 
LYS H    H  N N 247 
LYS H2   H  N N 248 
LYS HA   H  N N 249 
LYS HB2  H  N N 250 
LYS HB3  H  N N 251 
LYS HG2  H  N N 252 
LYS HG3  H  N N 253 
LYS HD2  H  N N 254 
LYS HD3  H  N N 255 
LYS HE2  H  N N 256 
LYS HE3  H  N N 257 
LYS HZ1  H  N N 258 
LYS HZ2  H  N N 259 
LYS HZ3  H  N N 260 
LYS HXT  H  N N 261 
MES O1   O  N N 262 
MES C2   C  N N 263 
MES C3   C  N N 264 
MES N4   N  N N 265 
MES C5   C  N N 266 
MES C6   C  N N 267 
MES C7   C  N N 268 
MES C8   C  N N 269 
MES S    S  N N 270 
MES O1S  O  N N 271 
MES O2S  O  N N 272 
MES O3S  O  N N 273 
MES H21  H  N N 274 
MES H22  H  N N 275 
MES H31  H  N N 276 
MES H32  H  N N 277 
MES HN4  H  N N 278 
MES H51  H  N N 279 
MES H52  H  N N 280 
MES H61  H  N N 281 
MES H62  H  N N 282 
MES H71  H  N N 283 
MES H72  H  N N 284 
MES H81  H  N N 285 
MES H82  H  N N 286 
MET N    N  N N 287 
MET CA   C  N S 288 
MET C    C  N N 289 
MET O    O  N N 290 
MET CB   C  N N 291 
MET CG   C  N N 292 
MET SD   S  N N 293 
MET CE   C  N N 294 
MET OXT  O  N N 295 
MET H    H  N N 296 
MET H2   H  N N 297 
MET HA   H  N N 298 
MET HB2  H  N N 299 
MET HB3  H  N N 300 
MET HG2  H  N N 301 
MET HG3  H  N N 302 
MET HE1  H  N N 303 
MET HE2  H  N N 304 
MET HE3  H  N N 305 
MET HXT  H  N N 306 
PEG C1   C  N N 307 
PEG O1   O  N N 308 
PEG C2   C  N N 309 
PEG O2   O  N N 310 
PEG C3   C  N N 311 
PEG C4   C  N N 312 
PEG O4   O  N N 313 
PEG H11  H  N N 314 
PEG H12  H  N N 315 
PEG HO1  H  N N 316 
PEG H21  H  N N 317 
PEG H22  H  N N 318 
PEG H31  H  N N 319 
PEG H32  H  N N 320 
PEG H41  H  N N 321 
PEG H42  H  N N 322 
PEG HO4  H  N N 323 
PHE N    N  N N 324 
PHE CA   C  N S 325 
PHE C    C  N N 326 
PHE O    O  N N 327 
PHE CB   C  N N 328 
PHE CG   C  Y N 329 
PHE CD1  C  Y N 330 
PHE CD2  C  Y N 331 
PHE CE1  C  Y N 332 
PHE CE2  C  Y N 333 
PHE CZ   C  Y N 334 
PHE OXT  O  N N 335 
PHE H    H  N N 336 
PHE H2   H  N N 337 
PHE HA   H  N N 338 
PHE HB2  H  N N 339 
PHE HB3  H  N N 340 
PHE HD1  H  N N 341 
PHE HD2  H  N N 342 
PHE HE1  H  N N 343 
PHE HE2  H  N N 344 
PHE HZ   H  N N 345 
PHE HXT  H  N N 346 
PO4 P    P  N N 347 
PO4 O1   O  N N 348 
PO4 O2   O  N N 349 
PO4 O3   O  N N 350 
PO4 O4   O  N N 351 
PRO N    N  N N 352 
PRO CA   C  N S 353 
PRO C    C  N N 354 
PRO O    O  N N 355 
PRO CB   C  N N 356 
PRO CG   C  N N 357 
PRO CD   C  N N 358 
PRO OXT  O  N N 359 
PRO H    H  N N 360 
PRO HA   H  N N 361 
PRO HB2  H  N N 362 
PRO HB3  H  N N 363 
PRO HG2  H  N N 364 
PRO HG3  H  N N 365 
PRO HD2  H  N N 366 
PRO HD3  H  N N 367 
PRO HXT  H  N N 368 
SER N    N  N N 369 
SER CA   C  N S 370 
SER C    C  N N 371 
SER O    O  N N 372 
SER CB   C  N N 373 
SER OG   O  N N 374 
SER OXT  O  N N 375 
SER H    H  N N 376 
SER H2   H  N N 377 
SER HA   H  N N 378 
SER HB2  H  N N 379 
SER HB3  H  N N 380 
SER HG   H  N N 381 
SER HXT  H  N N 382 
THR N    N  N N 383 
THR CA   C  N S 384 
THR C    C  N N 385 
THR O    O  N N 386 
THR CB   C  N R 387 
THR OG1  O  N N 388 
THR CG2  C  N N 389 
THR OXT  O  N N 390 
THR H    H  N N 391 
THR H2   H  N N 392 
THR HA   H  N N 393 
THR HB   H  N N 394 
THR HG1  H  N N 395 
THR HG21 H  N N 396 
THR HG22 H  N N 397 
THR HG23 H  N N 398 
THR HXT  H  N N 399 
TRP N    N  N N 400 
TRP CA   C  N S 401 
TRP C    C  N N 402 
TRP O    O  N N 403 
TRP CB   C  N N 404 
TRP CG   C  Y N 405 
TRP CD1  C  Y N 406 
TRP CD2  C  Y N 407 
TRP NE1  N  Y N 408 
TRP CE2  C  Y N 409 
TRP CE3  C  Y N 410 
TRP CZ2  C  Y N 411 
TRP CZ3  C  Y N 412 
TRP CH2  C  Y N 413 
TRP OXT  O  N N 414 
TRP H    H  N N 415 
TRP H2   H  N N 416 
TRP HA   H  N N 417 
TRP HB2  H  N N 418 
TRP HB3  H  N N 419 
TRP HD1  H  N N 420 
TRP HE1  H  N N 421 
TRP HE3  H  N N 422 
TRP HZ2  H  N N 423 
TRP HZ3  H  N N 424 
TRP HH2  H  N N 425 
TRP HXT  H  N N 426 
TYR N    N  N N 427 
TYR CA   C  N S 428 
TYR C    C  N N 429 
TYR O    O  N N 430 
TYR CB   C  N N 431 
TYR CG   C  Y N 432 
TYR CD1  C  Y N 433 
TYR CD2  C  Y N 434 
TYR CE1  C  Y N 435 
TYR CE2  C  Y N 436 
TYR CZ   C  Y N 437 
TYR OH   O  N N 438 
TYR OXT  O  N N 439 
TYR H    H  N N 440 
TYR H2   H  N N 441 
TYR HA   H  N N 442 
TYR HB2  H  N N 443 
TYR HB3  H  N N 444 
TYR HD1  H  N N 445 
TYR HD2  H  N N 446 
TYR HE1  H  N N 447 
TYR HE2  H  N N 448 
TYR HH   H  N N 449 
TYR HXT  H  N N 450 
VAL N    N  N N 451 
VAL CA   C  N S 452 
VAL C    C  N N 453 
VAL O    O  N N 454 
VAL CB   C  N N 455 
VAL CG1  C  N N 456 
VAL CG2  C  N N 457 
VAL OXT  O  N N 458 
VAL H    H  N N 459 
VAL H2   H  N N 460 
VAL HA   H  N N 461 
VAL HB   H  N N 462 
VAL HG11 H  N N 463 
VAL HG12 H  N N 464 
VAL HG13 H  N N 465 
VAL HG21 H  N N 466 
VAL HG22 H  N N 467 
VAL HG23 H  N N 468 
VAL HXT  H  N N 469 
ZN  ZN   ZN N N 470 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
DMS S   O    doub N N 83  
DMS S   C1   sing N N 84  
DMS S   C2   sing N N 85  
DMS C1  H11  sing N N 86  
DMS C1  H12  sing N N 87  
DMS C1  H13  sing N N 88  
DMS C2  H21  sing N N 89  
DMS C2  H22  sing N N 90  
DMS C2  H23  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
HIS N   CA   sing N N 138 
HIS N   H    sing N N 139 
HIS N   H2   sing N N 140 
HIS CA  C    sing N N 141 
HIS CA  CB   sing N N 142 
HIS CA  HA   sing N N 143 
HIS C   O    doub N N 144 
HIS C   OXT  sing N N 145 
HIS CB  CG   sing N N 146 
HIS CB  HB2  sing N N 147 
HIS CB  HB3  sing N N 148 
HIS CG  ND1  sing Y N 149 
HIS CG  CD2  doub Y N 150 
HIS ND1 CE1  doub Y N 151 
HIS ND1 HD1  sing N N 152 
HIS CD2 NE2  sing Y N 153 
HIS CD2 HD2  sing N N 154 
HIS CE1 NE2  sing Y N 155 
HIS CE1 HE1  sing N N 156 
HIS NE2 HE2  sing N N 157 
HIS OXT HXT  sing N N 158 
HOH O   H1   sing N N 159 
HOH O   H2   sing N N 160 
ILE N   CA   sing N N 161 
ILE N   H    sing N N 162 
ILE N   H2   sing N N 163 
ILE CA  C    sing N N 164 
ILE CA  CB   sing N N 165 
ILE CA  HA   sing N N 166 
ILE C   O    doub N N 167 
ILE C   OXT  sing N N 168 
ILE CB  CG1  sing N N 169 
ILE CB  CG2  sing N N 170 
ILE CB  HB   sing N N 171 
ILE CG1 CD1  sing N N 172 
ILE CG1 HG12 sing N N 173 
ILE CG1 HG13 sing N N 174 
ILE CG2 HG21 sing N N 175 
ILE CG2 HG22 sing N N 176 
ILE CG2 HG23 sing N N 177 
ILE CD1 HD11 sing N N 178 
ILE CD1 HD12 sing N N 179 
ILE CD1 HD13 sing N N 180 
ILE OXT HXT  sing N N 181 
K6U C1  O1   sing N N 182 
K6U O1  C2   sing N N 183 
K6U C2  C3   doub Y N 184 
K6U C3  C4   sing Y N 185 
K6U C4  C5   doub Y N 186 
K6U C5  C6   sing Y N 187 
K6U C6  C7   doub Y N 188 
K6U C7  C8   sing N N 189 
K6U C8  N1   doub Y N 190 
K6U N1  N2   sing Y N 191 
K6U N2  C9   doub Y N 192 
K6U C9  O2   sing Y N 193 
K6U C2  C7   sing Y N 194 
K6U C8  O2   sing Y N 195 
K6U C4  H5   sing N N 196 
K6U C5  H6   sing N N 197 
K6U C6  H7   sing N N 198 
K6U C1  H3   sing N N 199 
K6U C1  H2   sing N N 200 
K6U C1  H1   sing N N 201 
K6U C3  H4   sing N N 202 
K6U C9  H8   sing N N 203 
LEU N   CA   sing N N 204 
LEU N   H    sing N N 205 
LEU N   H2   sing N N 206 
LEU CA  C    sing N N 207 
LEU CA  CB   sing N N 208 
LEU CA  HA   sing N N 209 
LEU C   O    doub N N 210 
LEU C   OXT  sing N N 211 
LEU CB  CG   sing N N 212 
LEU CB  HB2  sing N N 213 
LEU CB  HB3  sing N N 214 
LEU CG  CD1  sing N N 215 
LEU CG  CD2  sing N N 216 
LEU CG  HG   sing N N 217 
LEU CD1 HD11 sing N N 218 
LEU CD1 HD12 sing N N 219 
LEU CD1 HD13 sing N N 220 
LEU CD2 HD21 sing N N 221 
LEU CD2 HD22 sing N N 222 
LEU CD2 HD23 sing N N 223 
LEU OXT HXT  sing N N 224 
LYS N   CA   sing N N 225 
LYS N   H    sing N N 226 
LYS N   H2   sing N N 227 
LYS CA  C    sing N N 228 
LYS CA  CB   sing N N 229 
LYS CA  HA   sing N N 230 
LYS C   O    doub N N 231 
LYS C   OXT  sing N N 232 
LYS CB  CG   sing N N 233 
LYS CB  HB2  sing N N 234 
LYS CB  HB3  sing N N 235 
LYS CG  CD   sing N N 236 
LYS CG  HG2  sing N N 237 
LYS CG  HG3  sing N N 238 
LYS CD  CE   sing N N 239 
LYS CD  HD2  sing N N 240 
LYS CD  HD3  sing N N 241 
LYS CE  NZ   sing N N 242 
LYS CE  HE2  sing N N 243 
LYS CE  HE3  sing N N 244 
LYS NZ  HZ1  sing N N 245 
LYS NZ  HZ2  sing N N 246 
LYS NZ  HZ3  sing N N 247 
LYS OXT HXT  sing N N 248 
MES O1  C2   sing N N 249 
MES O1  C6   sing N N 250 
MES C2  C3   sing N N 251 
MES C2  H21  sing N N 252 
MES C2  H22  sing N N 253 
MES C3  N4   sing N N 254 
MES C3  H31  sing N N 255 
MES C3  H32  sing N N 256 
MES N4  C5   sing N N 257 
MES N4  C7   sing N N 258 
MES N4  HN4  sing N N 259 
MES C5  C6   sing N N 260 
MES C5  H51  sing N N 261 
MES C5  H52  sing N N 262 
MES C6  H61  sing N N 263 
MES C6  H62  sing N N 264 
MES C7  C8   sing N N 265 
MES C7  H71  sing N N 266 
MES C7  H72  sing N N 267 
MES C8  S    sing N N 268 
MES C8  H81  sing N N 269 
MES C8  H82  sing N N 270 
MES S   O1S  doub N N 271 
MES S   O2S  doub N N 272 
MES S   O3S  sing N N 273 
MET N   CA   sing N N 274 
MET N   H    sing N N 275 
MET N   H2   sing N N 276 
MET CA  C    sing N N 277 
MET CA  CB   sing N N 278 
MET CA  HA   sing N N 279 
MET C   O    doub N N 280 
MET C   OXT  sing N N 281 
MET CB  CG   sing N N 282 
MET CB  HB2  sing N N 283 
MET CB  HB3  sing N N 284 
MET CG  SD   sing N N 285 
MET CG  HG2  sing N N 286 
MET CG  HG3  sing N N 287 
MET SD  CE   sing N N 288 
MET CE  HE1  sing N N 289 
MET CE  HE2  sing N N 290 
MET CE  HE3  sing N N 291 
MET OXT HXT  sing N N 292 
PEG C1  O1   sing N N 293 
PEG C1  C2   sing N N 294 
PEG C1  H11  sing N N 295 
PEG C1  H12  sing N N 296 
PEG O1  HO1  sing N N 297 
PEG C2  O2   sing N N 298 
PEG C2  H21  sing N N 299 
PEG C2  H22  sing N N 300 
PEG O2  C3   sing N N 301 
PEG C3  C4   sing N N 302 
PEG C3  H31  sing N N 303 
PEG C3  H32  sing N N 304 
PEG C4  O4   sing N N 305 
PEG C4  H41  sing N N 306 
PEG C4  H42  sing N N 307 
PEG O4  HO4  sing N N 308 
PHE N   CA   sing N N 309 
PHE N   H    sing N N 310 
PHE N   H2   sing N N 311 
PHE CA  C    sing N N 312 
PHE CA  CB   sing N N 313 
PHE CA  HA   sing N N 314 
PHE C   O    doub N N 315 
PHE C   OXT  sing N N 316 
PHE CB  CG   sing N N 317 
PHE CB  HB2  sing N N 318 
PHE CB  HB3  sing N N 319 
PHE CG  CD1  doub Y N 320 
PHE CG  CD2  sing Y N 321 
PHE CD1 CE1  sing Y N 322 
PHE CD1 HD1  sing N N 323 
PHE CD2 CE2  doub Y N 324 
PHE CD2 HD2  sing N N 325 
PHE CE1 CZ   doub Y N 326 
PHE CE1 HE1  sing N N 327 
PHE CE2 CZ   sing Y N 328 
PHE CE2 HE2  sing N N 329 
PHE CZ  HZ   sing N N 330 
PHE OXT HXT  sing N N 331 
PO4 P   O1   doub N N 332 
PO4 P   O2   sing N N 333 
PO4 P   O3   sing N N 334 
PO4 P   O4   sing N N 335 
PRO N   CA   sing N N 336 
PRO N   CD   sing N N 337 
PRO N   H    sing N N 338 
PRO CA  C    sing N N 339 
PRO CA  CB   sing N N 340 
PRO CA  HA   sing N N 341 
PRO C   O    doub N N 342 
PRO C   OXT  sing N N 343 
PRO CB  CG   sing N N 344 
PRO CB  HB2  sing N N 345 
PRO CB  HB3  sing N N 346 
PRO CG  CD   sing N N 347 
PRO CG  HG2  sing N N 348 
PRO CG  HG3  sing N N 349 
PRO CD  HD2  sing N N 350 
PRO CD  HD3  sing N N 351 
PRO OXT HXT  sing N N 352 
SER N   CA   sing N N 353 
SER N   H    sing N N 354 
SER N   H2   sing N N 355 
SER CA  C    sing N N 356 
SER CA  CB   sing N N 357 
SER CA  HA   sing N N 358 
SER C   O    doub N N 359 
SER C   OXT  sing N N 360 
SER CB  OG   sing N N 361 
SER CB  HB2  sing N N 362 
SER CB  HB3  sing N N 363 
SER OG  HG   sing N N 364 
SER OXT HXT  sing N N 365 
THR N   CA   sing N N 366 
THR N   H    sing N N 367 
THR N   H2   sing N N 368 
THR CA  C    sing N N 369 
THR CA  CB   sing N N 370 
THR CA  HA   sing N N 371 
THR C   O    doub N N 372 
THR C   OXT  sing N N 373 
THR CB  OG1  sing N N 374 
THR CB  CG2  sing N N 375 
THR CB  HB   sing N N 376 
THR OG1 HG1  sing N N 377 
THR CG2 HG21 sing N N 378 
THR CG2 HG22 sing N N 379 
THR CG2 HG23 sing N N 380 
THR OXT HXT  sing N N 381 
TRP N   CA   sing N N 382 
TRP N   H    sing N N 383 
TRP N   H2   sing N N 384 
TRP CA  C    sing N N 385 
TRP CA  CB   sing N N 386 
TRP CA  HA   sing N N 387 
TRP C   O    doub N N 388 
TRP C   OXT  sing N N 389 
TRP CB  CG   sing N N 390 
TRP CB  HB2  sing N N 391 
TRP CB  HB3  sing N N 392 
TRP CG  CD1  doub Y N 393 
TRP CG  CD2  sing Y N 394 
TRP CD1 NE1  sing Y N 395 
TRP CD1 HD1  sing N N 396 
TRP CD2 CE2  doub Y N 397 
TRP CD2 CE3  sing Y N 398 
TRP NE1 CE2  sing Y N 399 
TRP NE1 HE1  sing N N 400 
TRP CE2 CZ2  sing Y N 401 
TRP CE3 CZ3  doub Y N 402 
TRP CE3 HE3  sing N N 403 
TRP CZ2 CH2  doub Y N 404 
TRP CZ2 HZ2  sing N N 405 
TRP CZ3 CH2  sing Y N 406 
TRP CZ3 HZ3  sing N N 407 
TRP CH2 HH2  sing N N 408 
TRP OXT HXT  sing N N 409 
TYR N   CA   sing N N 410 
TYR N   H    sing N N 411 
TYR N   H2   sing N N 412 
TYR CA  C    sing N N 413 
TYR CA  CB   sing N N 414 
TYR CA  HA   sing N N 415 
TYR C   O    doub N N 416 
TYR C   OXT  sing N N 417 
TYR CB  CG   sing N N 418 
TYR CB  HB2  sing N N 419 
TYR CB  HB3  sing N N 420 
TYR CG  CD1  doub Y N 421 
TYR CG  CD2  sing Y N 422 
TYR CD1 CE1  sing Y N 423 
TYR CD1 HD1  sing N N 424 
TYR CD2 CE2  doub Y N 425 
TYR CD2 HD2  sing N N 426 
TYR CE1 CZ   doub Y N 427 
TYR CE1 HE1  sing N N 428 
TYR CE2 CZ   sing Y N 429 
TYR CE2 HE2  sing N N 430 
TYR CZ  OH   sing N N 431 
TYR OH  HH   sing N N 432 
TYR OXT HXT  sing N N 433 
VAL N   CA   sing N N 434 
VAL N   H    sing N N 435 
VAL N   H2   sing N N 436 
VAL CA  C    sing N N 437 
VAL CA  CB   sing N N 438 
VAL CA  HA   sing N N 439 
VAL C   O    doub N N 440 
VAL C   OXT  sing N N 441 
VAL CB  CG1  sing N N 442 
VAL CB  CG2  sing N N 443 
VAL CB  HB   sing N N 444 
VAL CG1 HG11 sing N N 445 
VAL CG1 HG12 sing N N 446 
VAL CG1 HG13 sing N N 447 
VAL CG2 HG21 sing N N 448 
VAL CG2 HG22 sing N N 449 
VAL CG2 HG23 sing N N 450 
VAL OXT HXT  sing N N 451 
# 
_pdbx_audit_support.ordinal                1 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)' 
_pdbx_audit_support.grant_number           U19AI171292 
_pdbx_audit_support.country                'United States' 
# 
_pdbx_deposit_group.group_id            G_1002341 
_pdbx_deposit_group.group_description   
'Crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_title         
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_type          'changed state' 
# 
_atom_sites.entry_id                    7I2H 
_atom_sites.fract_transf_matrix[1][1]   0.012140 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.008658 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006820 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
# 
loop_
_atom_type.symbol 
C  
CL 
N  
O  
P  
S  
ZN 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ASN A 1 10  ? -14.201 -5.706  -12.150 0.26 109.57 ? 273  ASN A N   1 
ATOM   2    C  CA  . ASN A 1 10  ? -13.829 -6.726  -11.135 0.26 110.10 ? 273  ASN A CA  1 
ATOM   3    C  C   . ASN A 1 10  ? -14.840 -6.692  -9.987  0.26 109.34 ? 273  ASN A C   1 
ATOM   4    O  O   . ASN A 1 10  ? -15.790 -7.495  -10.017 0.26 108.72 ? 273  ASN A O   1 
ATOM   5    C  CB  . ASN A 1 10  ? -12.407 -6.518  -10.609 0.26 110.95 ? 273  ASN A CB  1 
ATOM   6    C  CG  . ASN A 1 10  ? -12.024 -7.514  -9.535  0.26 111.01 ? 273  ASN A CG  1 
ATOM   7    O  OD1 . ASN A 1 10  ? -12.653 -8.561  -9.398  0.26 110.26 ? 273  ASN A OD1 1 
ATOM   8    N  ND2 . ASN A 1 10  ? -10.992 -7.199  -8.770  0.26 109.73 ? 273  ASN A ND2 1 
ATOM   9    N  N   . LEU A 1 11  ? -14.626 -5.807  -9.009  1.00 110.04 ? 274  LEU A N   1 
ATOM   10   C  CA  . LEU A 1 11  ? -15.530 -5.750  -7.832  1.00 98.95  ? 274  LEU A CA  1 
ATOM   11   C  C   . LEU A 1 11  ? -16.893 -5.243  -8.290  1.00 91.57  ? 274  LEU A C   1 
ATOM   12   O  O   . LEU A 1 11  ? -17.896 -5.610  -7.665  1.00 80.64  ? 274  LEU A O   1 
ATOM   13   C  CB  . LEU A 1 11  ? -14.921 -4.847  -6.758  1.00 99.18  ? 274  LEU A CB  1 
ATOM   14   C  CG  . LEU A 1 11  ? -14.247 -5.592  -5.607  1.00 97.29  ? 274  LEU A CG  1 
ATOM   15   C  CD1 . LEU A 1 11  ? -13.525 -4.627  -4.680  1.00 92.26  ? 274  LEU A CD1 1 
ATOM   16   C  CD2 . LEU A 1 11  ? -15.261 -6.418  -4.832  1.00 89.09  ? 274  LEU A CD2 1 
ATOM   17   N  N   . ASP A 1 12  ? -16.916 -4.439  -9.349  1.00 81.86  ? 275  ASP A N   1 
ATOM   18   C  CA  . ASP A 1 12  ? -18.222 -4.009  -9.900  1.00 92.80  ? 275  ASP A CA  1 
ATOM   19   C  C   . ASP A 1 12  ? -18.974 -5.255  -10.364 1.00 94.48  ? 275  ASP A C   1 
ATOM   20   O  O   . ASP A 1 12  ? -20.202 -5.292  -10.184 1.00 88.86  ? 275  ASP A O   1 
ATOM   21   C  CB  . ASP A 1 12  ? -18.042 -3.001  -11.036 1.00 97.71  ? 275  ASP A CB  1 
ATOM   22   C  CG  . ASP A 1 12  ? -16.991 -3.409  -12.050 1.00 100.18 ? 275  ASP A CG  1 
ATOM   23   O  OD1 . ASP A 1 12  ? -15.967 -3.977  -11.633 1.00 109.30 ? 275  ASP A OD1 1 
ATOM   24   O  OD2 . ASP A 1 12  ? -17.210 -3.158  -13.250 1.00 99.78  ? 275  ASP A OD2 1 
ATOM   25   N  N   . ILE A 1 13  ? -18.256 -6.241  -10.912 1.00 91.23  ? 276  ILE A N   1 
ATOM   26   C  CA  . ILE A 1 13  ? -18.910 -7.456  -11.483 1.00 75.02  ? 276  ILE A CA  1 
ATOM   27   C  C   . ILE A 1 13  ? -19.206 -8.482  -10.387 1.00 69.80  ? 276  ILE A C   1 
ATOM   28   O  O   . ILE A 1 13  ? -20.171 -9.234  -10.561 1.00 63.27  ? 276  ILE A O   1 
ATOM   29   C  CB  . ILE A 1 13  ? -18.027 -8.028  -12.610 1.00 76.77  ? 276  ILE A CB  1 
ATOM   30   C  CG1 . ILE A 1 13  ? -17.897 -7.032  -13.764 1.00 70.49  ? 276  ILE A CG1 1 
ATOM   31   C  CG2 . ILE A 1 13  ? -18.535 -9.380  -13.081 1.00 74.20  ? 276  ILE A CG2 1 
ATOM   32   C  CD1 . ILE A 1 13  ? -16.986 -7.489  -14.874 1.00 68.89  ? 276  ILE A CD1 1 
ATOM   33   N  N   . ILE A 1 14  ? -18.448 -8.481  -9.288  0.26 73.24  ? 277  ILE A N   1 
ATOM   34   C  CA  . ILE A 1 14  ? -18.628 -9.538  -8.246  0.26 77.06  ? 277  ILE A CA  1 
ATOM   35   C  C   . ILE A 1 14  ? -19.238 -8.944  -6.973  0.26 77.93  ? 277  ILE A C   1 
ATOM   36   O  O   . ILE A 1 14  ? -19.866 -9.708  -6.217  0.26 76.85  ? 277  ILE A O   1 
ATOM   37   C  CB  . ILE A 1 14  ? -17.275 -10.220 -7.962  0.26 79.75  ? 277  ILE A CB  1 
ATOM   38   C  CG1 . ILE A 1 14  ? -16.255 -9.231  -7.392  0.26 79.56  ? 277  ILE A CG1 1 
ATOM   39   C  CG2 . ILE A 1 14  ? -16.751 -10.912 -9.210  0.26 80.44  ? 277  ILE A CG2 1 
ATOM   40   C  CD1 . ILE A 1 14  ? -14.884 -9.825  -7.169  0.26 80.29  ? 277  ILE A CD1 1 
ATOM   41   N  N   . GLY A 1 15  ? -19.070 -7.640  -6.746  1.00 83.70  ? 278  GLY A N   1 
ATOM   42   C  CA  . GLY A 1 15  ? -19.549 -6.999  -5.502  1.00 78.85  ? 278  GLY A CA  1 
ATOM   43   C  C   . GLY A 1 15  ? -20.991 -7.322  -5.187  1.00 77.57  ? 278  GLY A C   1 
ATOM   44   O  O   . GLY A 1 15  ? -21.265 -7.760  -4.061  1.00 85.72  ? 278  GLY A O   1 
ATOM   45   N  N   . LYS A 1 16  ? -21.881 -7.109  -6.150  1.00 74.80  ? 279  LYS A N   1 
ATOM   46   C  CA  . LYS A 1 16  ? -23.328 -7.367  -5.940  1.00 71.92  ? 279  LYS A CA  1 
ATOM   47   C  C   . LYS A 1 16  ? -23.521 -8.778  -5.369  1.00 71.51  ? 279  LYS A C   1 
ATOM   48   O  O   . LYS A 1 16  ? -24.260 -8.936  -4.381  1.00 64.17  ? 279  LYS A O   1 
ATOM   49   C  CB  . LYS A 1 16  ? -24.023 -7.157  -7.287  1.00 77.24  ? 279  LYS A CB  1 
ATOM   50   C  CG  . LYS A 1 16  ? -25.538 -7.287  -7.311  1.00 82.01  ? 279  LYS A CG  1 
ATOM   51   C  CD  . LYS A 1 16  ? -26.133 -6.683  -8.584  1.00 87.08  ? 279  LYS A CD  1 
ATOM   52   C  CE  . LYS A 1 16  ? -27.645 -6.731  -8.643  1.00 89.94  ? 279  LYS A CE  1 
ATOM   53   N  NZ  . LYS A 1 16  ? -28.251 -5.548  -7.994  1.00 97.85  ? 279  LYS A NZ  1 
ATOM   54   N  N   . ARG A 1 17  ? -22.884 -9.776  -5.985  1.00 75.65  ? 280  ARG A N   1 
ATOM   55   C  CA  . ARG A 1 17  ? -22.978 -11.198 -5.555  1.00 77.71  ? 280  ARG A CA  1 
ATOM   56   C  C   . ARG A 1 17  ? -22.504 -11.303 -4.107  1.00 77.14  ? 280  ARG A C   1 
ATOM   57   O  O   . ARG A 1 17  ? -23.197 -11.964 -3.299  1.00 75.46  ? 280  ARG A O   1 
ATOM   58   C  CB  . ARG A 1 17  ? -22.130 -12.112 -6.447  1.00 76.64  ? 280  ARG A CB  1 
ATOM   59   C  CG  . ARG A 1 17  ? -22.930 -12.923 -7.454  1.00 76.34  ? 280  ARG A CG  1 
ATOM   60   C  CD  . ARG A 1 17  ? -22.037 -13.634 -8.450  1.00 60.13  ? 280  ARG A CD  1 
ATOM   61   N  NE  . ARG A 1 17  ? -21.445 -12.684 -9.375  1.00 58.79  ? 280  ARG A NE  1 
ATOM   62   C  CZ  . ARG A 1 17  ? -20.664 -13.002 -10.400 1.00 58.52  ? 280  ARG A CZ  1 
ATOM   63   N  NH1 . ARG A 1 17  ? -20.345 -14.264 -10.629 1.00 61.65  ? 280  ARG A NH1 1 
ATOM   64   N  NH2 . ARG A 1 17  ? -20.207 -12.055 -11.202 1.00 59.76  ? 280  ARG A NH2 1 
ATOM   65   N  N   . ILE A 1 18  ? -21.370 -10.659 -3.816  1.00 81.14  ? 281  ILE A N   1 
ATOM   66   C  CA  . ILE A 1 18  ? -20.694 -10.675 -2.486  1.00 86.75  ? 281  ILE A CA  1 
ATOM   67   C  C   . ILE A 1 18  ? -21.602 -9.953  -1.484  1.00 89.02  ? 281  ILE A C   1 
ATOM   68   O  O   . ILE A 1 18  ? -21.902 -10.534 -0.402  1.00 84.42  ? 281  ILE A O   1 
ATOM   69   C  CB  . ILE A 1 18  ? -19.275 -10.065 -2.581  1.00 90.69  ? 281  ILE A CB  1 
ATOM   70   C  CG1 . ILE A 1 18  ? -18.382 -10.875 -3.526  1.00 89.83  ? 281  ILE A CG1 1 
ATOM   71   C  CG2 . ILE A 1 18  ? -18.627 -9.938  -1.207  1.00 92.58  ? 281  ILE A CG2 1 
ATOM   72   C  CD1 . ILE A 1 18  ? -17.099 -10.182 -3.899  1.00 92.65  ? 281  ILE A CD1 1 
ATOM   73   N  N   . GLU A 1 19  ? -22.037 -8.737  -1.838  0.26 88.88  ? 282  GLU A N   1 
ATOM   74   C  CA  . GLU A 1 19  ? -22.901 -7.854  -1.005  0.26 87.12  ? 282  GLU A CA  1 
ATOM   75   C  C   . GLU A 1 19  ? -24.136 -8.630  -0.533  0.26 84.08  ? 282  GLU A C   1 
ATOM   76   O  O   . GLU A 1 19  ? -24.465 -8.525  0.663   0.26 81.64  ? 282  GLU A O   1 
ATOM   77   C  CB  . GLU A 1 19  ? -23.316 -6.605  -1.785  0.26 89.31  ? 282  GLU A CB  1 
ATOM   78   C  CG  . GLU A 1 19  ? -22.234 -5.540  -1.843  0.26 93.14  ? 282  GLU A CG  1 
ATOM   79   C  CD  . GLU A 1 19  ? -22.435 -4.471  -2.905  0.26 96.39  ? 282  GLU A CD  1 
ATOM   80   O  OE1 . GLU A 1 19  ? -23.581 -4.305  -3.373  0.26 100.96 ? 282  GLU A OE1 1 
ATOM   81   O  OE2 . GLU A 1 19  ? -21.442 -3.807  -3.267  0.26 97.59  ? 282  GLU A OE2 1 
ATOM   82   N  N   . LYS A 1 20  ? -24.782 -9.377  -1.436  0.26 85.72  ? 283  LYS A N   1 
ATOM   83   C  CA  . LYS A 1 20  ? -26.034 -10.136 -1.157  0.26 88.27  ? 283  LYS A CA  1 
ATOM   84   C  C   . LYS A 1 20  ? -25.754 -11.248 -0.139  0.26 90.60  ? 283  LYS A C   1 
ATOM   85   O  O   . LYS A 1 20  ? -26.571 -11.408 0.791   0.26 90.88  ? 283  LYS A O   1 
ATOM   86   C  CB  . LYS A 1 20  ? -26.621 -10.728 -2.441  0.26 88.21  ? 283  LYS A CB  1 
ATOM   87   C  CG  . LYS A 1 20  ? -27.845 -11.612 -2.233  0.26 88.45  ? 283  LYS A CG  1 
ATOM   88   C  CD  . LYS A 1 20  ? -28.720 -11.752 -3.460  0.26 89.86  ? 283  LYS A CD  1 
ATOM   89   C  CE  . LYS A 1 20  ? -30.042 -12.434 -3.172  0.26 89.47  ? 283  LYS A CE  1 
ATOM   90   N  NZ  . LYS A 1 20  ? -29.870 -13.882 -2.903  0.26 89.30  ? 283  LYS A NZ  1 
ATOM   91   N  N   . ILE A 1 21  ? -24.654 -11.987 -0.321  1.00 90.64  ? 284  ILE A N   1 
ATOM   92   C  CA  . ILE A 1 21  ? -24.277 -13.118 0.573   1.00 95.86  ? 284  ILE A CA  1 
ATOM   93   C  C   . ILE A 1 21  ? -23.932 -12.567 1.967   1.00 96.62  ? 284  ILE A C   1 
ATOM   94   O  O   . ILE A 1 21  ? -24.381 -13.177 2.972   1.00 83.12  ? 284  ILE A O   1 
ATOM   95   C  CB  . ILE A 1 21  ? -23.135 -13.935 -0.058  1.00 102.52 ? 284  ILE A CB  1 
ATOM   96   C  CG1 . ILE A 1 21  ? -23.616 -14.623 -1.338  1.00 99.70  ? 284  ILE A CG1 1 
ATOM   97   C  CG2 . ILE A 1 21  ? -22.556 -14.926 0.944   1.00 104.49 ? 284  ILE A CG2 1 
ATOM   98   C  CD1 . ILE A 1 21  ? -22.523 -15.280 -2.152  1.00 98.19  ? 284  ILE A CD1 1 
ATOM   99   N  N   . LYS A 1 22  ? -23.198 -11.450 2.029   1.00 91.96  ? 285  LYS A N   1 
ATOM   100  C  CA  . LYS A 1 22  ? -22.846 -10.781 3.312   1.00 96.34  ? 285  LYS A CA  1 
ATOM   101  C  C   . LYS A 1 22  ? -24.135 -10.526 4.095   1.00 95.21  ? 285  LYS A C   1 
ATOM   102  O  O   . LYS A 1 22  ? -24.273 -11.110 5.184   1.00 91.56  ? 285  LYS A O   1 
ATOM   103  C  CB  . LYS A 1 22  ? -22.073 -9.480  3.084   1.00 100.41 ? 285  LYS A CB  1 
ATOM   104  C  CG  . LYS A 1 22  ? -21.674 -8.744  4.358   1.00 111.75 ? 285  LYS A CG  1 
ATOM   105  C  CD  . LYS A 1 22  ? -20.733 -7.573  4.127   1.00 116.22 ? 285  LYS A CD  1 
ATOM   106  C  CE  . LYS A 1 22  ? -20.793 -6.527  5.222   1.00 113.64 ? 285  LYS A CE  1 
ATOM   107  N  NZ  . LYS A 1 22  ? -19.977 -5.340  4.875   1.00 113.99 ? 285  LYS A NZ  1 
ATOM   108  N  N   . GLN A 1 23  ? -25.056 -9.744  3.516   1.00 106.64 ? 286  GLN A N   1 
ATOM   109  C  CA  . GLN A 1 23  ? -26.369 -9.350  4.108   1.00 104.91 ? 286  GLN A CA  1 
ATOM   110  C  C   . GLN A 1 23  ? -27.145 -10.576 4.618   1.00 100.32 ? 286  GLN A C   1 
ATOM   111  O  O   . GLN A 1 23  ? -27.756 -10.462 5.688   1.00 104.53 ? 286  GLN A O   1 
ATOM   112  C  CB  . GLN A 1 23  ? -27.197 -8.560  3.091   1.00 107.71 ? 286  GLN A CB  1 
ATOM   113  C  CG  . GLN A 1 23  ? -26.711 -7.125  2.926   1.00 114.12 ? 286  GLN A CG  1 
ATOM   114  C  CD  . GLN A 1 23  ? -27.135 -6.489  1.625   1.00 117.46 ? 286  GLN A CD  1 
ATOM   115  O  OE1 . GLN A 1 23  ? -28.067 -6.941  0.957   1.00 113.41 ? 286  GLN A OE1 1 
ATOM   116  N  NE2 . GLN A 1 23  ? -26.442 -5.423  1.252   1.00 121.61 ? 286  GLN A NE2 1 
ATOM   117  N  N   . GLU A 1 24  ? -27.121 -11.707 3.910   1.00 99.04  ? 287  GLU A N   1 
ATOM   118  C  CA  . GLU A 1 24  ? -27.883 -12.923 4.303   1.00 101.03 ? 287  GLU A CA  1 
ATOM   119  C  C   . GLU A 1 24  ? -27.244 -13.575 5.537   1.00 103.51 ? 287  GLU A C   1 
ATOM   120  O  O   . GLU A 1 24  ? -27.918 -14.403 6.174   1.00 104.68 ? 287  GLU A O   1 
ATOM   121  C  CB  . GLU A 1 24  ? -27.989 -13.879 3.116   1.00 105.74 ? 287  GLU A CB  1 
ATOM   122  C  CG  . GLU A 1 24  ? -29.006 -13.402 2.096   1.00 117.16 ? 287  GLU A CG  1 
ATOM   123  C  CD  . GLU A 1 24  ? -28.763 -13.808 0.654   1.00 122.12 ? 287  GLU A CD  1 
ATOM   124  O  OE1 . GLU A 1 24  ? -29.760 -13.907 -0.095  1.00 125.92 ? 287  GLU A OE1 1 
ATOM   125  O  OE2 . GLU A 1 24  ? -27.588 -14.008 0.276   1.00 120.51 ? 287  GLU A OE2 1 
ATOM   126  N  N   . HIS A 1 25  ? -25.999 -13.215 5.862   1.00 114.86 ? 288  HIS A N   1 
ATOM   127  C  CA  . HIS A 1 25  ? -25.245 -13.716 7.043   1.00 117.06 ? 288  HIS A CA  1 
ATOM   128  C  C   . HIS A 1 25  ? -24.539 -12.540 7.730   1.00 122.71 ? 288  HIS A C   1 
ATOM   129  O  O   . HIS A 1 25  ? -23.300 -12.601 7.881   1.00 122.04 ? 288  HIS A O   1 
ATOM   130  C  CB  . HIS A 1 25  ? -24.254 -14.810 6.614   1.00 113.64 ? 288  HIS A CB  1 
ATOM   131  C  CG  . HIS A 1 25  ? -24.852 -15.890 5.777   1.00 103.99 ? 288  HIS A CG  1 
ATOM   132  N  ND1 . HIS A 1 25  ? -25.956 -16.614 6.180   1.00 96.68  ? 288  HIS A ND1 1 
ATOM   133  C  CD2 . HIS A 1 25  ? -24.500 -16.380 4.569   1.00 101.30 ? 288  HIS A CD2 1 
ATOM   134  C  CE1 . HIS A 1 25  ? -26.257 -17.506 5.257   1.00 94.62  ? 288  HIS A CE1 1 
ATOM   135  N  NE2 . HIS A 1 25  ? -25.378 -17.386 4.261   1.00 97.30  ? 288  HIS A NE2 1 
ATOM   136  N  N   . GLU A 1 26  ? -25.299 -11.516 8.142   1.00 123.95 ? 289  GLU A N   1 
ATOM   137  C  CA  . GLU A 1 26  ? -24.761 -10.234 8.691   1.00 123.08 ? 289  GLU A CA  1 
ATOM   138  C  C   . GLU A 1 26  ? -24.341 -10.388 10.166  1.00 120.87 ? 289  GLU A C   1 
ATOM   139  O  O   . GLU A 1 26  ? -23.707 -9.465  10.708  1.00 115.00 ? 289  GLU A O   1 
ATOM   140  C  CB  . GLU A 1 26  ? -25.793 -9.110  8.512   1.00 120.87 ? 289  GLU A CB  1 
ATOM   141  C  CG  . GLU A 1 26  ? -25.247 -7.684  8.649   1.00 114.76 ? 289  GLU A CG  1 
ATOM   142  C  CD  . GLU A 1 26  ? -24.294 -7.170  7.573   1.00 112.06 ? 289  GLU A CD  1 
ATOM   143  O  OE1 . GLU A 1 26  ? -23.096 -7.016  7.894   1.00 107.20 ? 289  GLU A OE1 1 
ATOM   144  O  OE2 . GLU A 1 26  ? -24.747 -6.882  6.428   1.00 98.37  ? 289  GLU A OE2 1 
ATOM   145  N  N   . THR A 1 27  ? -24.654 -11.534 10.783  0.26 119.70 ? 290  THR A N   1 
ATOM   146  C  CA  . THR A 1 27  ? -24.392 -11.825 12.220  0.26 120.02 ? 290  THR A CA  1 
ATOM   147  C  C   . THR A 1 27  ? -23.060 -12.572 12.401  0.26 119.63 ? 290  THR A C   1 
ATOM   148  O  O   . THR A 1 27  ? -22.621 -12.673 13.566  0.26 121.64 ? 290  THR A O   1 
ATOM   149  C  CB  . THR A 1 27  ? -25.561 -12.606 12.837  0.26 120.50 ? 290  THR A CB  1 
ATOM   150  O  OG1 . THR A 1 27  ? -25.806 -13.761 12.034  0.26 121.97 ? 290  THR A OG1 1 
ATOM   151  C  CG2 . THR A 1 27  ? -26.827 -11.785 12.940  0.26 119.14 ? 290  THR A CG2 1 
ATOM   152  N  N   . SER A 1 28  ? -22.434 -13.064 11.320  0.26 116.00 ? 291  SER A N   1 
ATOM   153  C  CA  . SER A 1 28  ? -21.231 -13.943 11.370  0.26 109.79 ? 291  SER A CA  1 
ATOM   154  C  C   . SER A 1 28  ? -20.107 -13.477 10.428  0.26 106.09 ? 291  SER A C   1 
ATOM   155  O  O   . SER A 1 28  ? -19.094 -14.199 10.352  0.26 107.12 ? 291  SER A O   1 
ATOM   156  C  CB  . SER A 1 28  ? -21.609 -15.372 11.063  0.26 109.14 ? 291  SER A CB  1 
ATOM   157  O  OG  . SER A 1 28  ? -22.614 -15.835 11.953  0.26 109.32 ? 291  SER A OG  1 
ATOM   158  N  N   . TRP A 1 29  ? -20.245 -12.331 9.750   0.26 103.80 ? 292  TRP A N   1 
ATOM   159  C  CA  . TRP A 1 29  ? -19.260 -11.855 8.737   0.26 103.40 ? 292  TRP A CA  1 
ATOM   160  C  C   . TRP A 1 29  ? -17.978 -11.381 9.436   0.26 103.22 ? 292  TRP A C   1 
ATOM   161  O  O   . TRP A 1 29  ? -18.089 -10.689 10.468  0.26 104.42 ? 292  TRP A O   1 
ATOM   162  C  CB  . TRP A 1 29  ? -19.860 -10.759 7.844   0.26 101.23 ? 292  TRP A CB  1 
ATOM   163  C  CG  . TRP A 1 29  ? -19.071 -10.491 6.596   0.26 99.69  ? 292  TRP A CG  1 
ATOM   164  C  CD1 . TRP A 1 29  ? -18.211 -9.455  6.374   0.26 99.64  ? 292  TRP A CD1 1 
ATOM   165  C  CD2 . TRP A 1 29  ? -19.065 -11.279 5.390   0.26 99.36  ? 292  TRP A CD2 1 
ATOM   166  N  NE1 . TRP A 1 29  ? -17.674 -9.539  5.117   0.26 98.64  ? 292  TRP A NE1 1 
ATOM   167  C  CE2 . TRP A 1 29  ? -18.178 -10.648 4.489   0.26 98.87  ? 292  TRP A CE2 1 
ATOM   168  C  CE3 . TRP A 1 29  ? -19.718 -12.449 4.982   0.26 98.02  ? 292  TRP A CE3 1 
ATOM   169  C  CZ2 . TRP A 1 29  ? -17.932 -11.150 3.211   0.26 97.32  ? 292  TRP A CZ2 1 
ATOM   170  C  CZ3 . TRP A 1 29  ? -19.474 -12.943 3.719   0.26 97.17  ? 292  TRP A CZ3 1 
ATOM   171  C  CH2 . TRP A 1 29  ? -18.593 -12.301 2.847   0.26 96.98  ? 292  TRP A CH2 1 
ATOM   172  N  N   . HIS A 1 30  ? -16.812 -11.753 8.894   0.26 102.80 ? 293  HIS A N   1 
ATOM   173  C  CA  . HIS A 1 30  ? -15.467 -11.371 9.406   0.26 101.35 ? 293  HIS A CA  1 
ATOM   174  C  C   . HIS A 1 30  ? -14.416 -11.523 8.298   0.26 101.17 ? 293  HIS A C   1 
ATOM   175  O  O   . HIS A 1 30  ? -14.454 -12.544 7.585   0.26 105.16 ? 293  HIS A O   1 
ATOM   176  C  CB  . HIS A 1 30  ? -15.110 -12.193 10.654  0.26 101.61 ? 293  HIS A CB  1 
ATOM   177  C  CG  . HIS A 1 30  ? -15.058 -13.669 10.436  0.26 100.32 ? 293  HIS A CG  1 
ATOM   178  N  ND1 . HIS A 1 30  ? -16.160 -14.484 10.619  0.26 100.65 ? 293  HIS A ND1 1 
ATOM   179  C  CD2 . HIS A 1 30  ? -14.041 -14.484 10.077  0.26 98.86  ? 293  HIS A CD2 1 
ATOM   180  C  CE1 . HIS A 1 30  ? -15.827 -15.735 10.374  0.26 99.64  ? 293  HIS A CE1 1 
ATOM   181  N  NE2 . HIS A 1 30  ? -14.531 -15.762 10.039  0.26 100.52 ? 293  HIS A NE2 1 
ATOM   182  N  N   . TYR A 1 31  ? -13.522 -10.537 8.166   0.26 99.35  ? 294  TYR A N   1 
ATOM   183  C  CA  . TYR A 1 31  ? -12.362 -10.548 7.235   0.26 98.93  ? 294  TYR A CA  1 
ATOM   184  C  C   . TYR A 1 31  ? -11.193 -11.267 7.920   0.26 98.83  ? 294  TYR A C   1 
ATOM   185  O  O   . TYR A 1 31  ? -10.309 -10.588 8.481   0.26 101.42 ? 294  TYR A O   1 
ATOM   186  C  CB  . TYR A 1 31  ? -12.006 -9.120  6.810   0.26 99.31  ? 294  TYR A CB  1 
ATOM   187  C  CG  . TYR A 1 31  ? -10.834 -9.007  5.866   0.26 101.92 ? 294  TYR A CG  1 
ATOM   188  C  CD1 . TYR A 1 31  ? -9.657  -8.384  6.256   0.26 102.99 ? 294  TYR A CD1 1 
ATOM   189  C  CD2 . TYR A 1 31  ? -10.897 -9.523  4.581   0.26 102.90 ? 294  TYR A CD2 1 
ATOM   190  C  CE1 . TYR A 1 31  ? -8.576  -8.276  5.395   0.26 103.20 ? 294  TYR A CE1 1 
ATOM   191  C  CE2 . TYR A 1 31  ? -9.825  -9.424  3.708   0.26 103.17 ? 294  TYR A CE2 1 
ATOM   192  C  CZ  . TYR A 1 31  ? -8.660  -8.798  4.116   0.26 103.26 ? 294  TYR A CZ  1 
ATOM   193  O  OH  . TYR A 1 31  ? -7.600  -8.695  3.264   0.26 104.98 ? 294  TYR A OH  1 
ATOM   194  N  N   . ASP A 1 32  ? -11.207 -12.604 7.883   0.26 98.07  ? 295  ASP A N   1 
ATOM   195  C  CA  . ASP A 1 32  ? -10.214 -13.490 8.553   0.26 98.26  ? 295  ASP A CA  1 
ATOM   196  C  C   . ASP A 1 32  ? -8.816  -13.170 8.005   0.26 99.65  ? 295  ASP A C   1 
ATOM   197  O  O   . ASP A 1 32  ? -8.687  -13.018 6.772   0.26 100.09 ? 295  ASP A O   1 
ATOM   198  C  CB  . ASP A 1 32  ? -10.585 -14.966 8.370   0.26 95.65  ? 295  ASP A CB  1 
ATOM   199  C  CG  . ASP A 1 32  ? -10.014 -15.891 9.431   0.26 93.26  ? 295  ASP A CG  1 
ATOM   200  O  OD1 . ASP A 1 32  ? -8.775  -15.937 9.565   0.26 94.25  ? 295  ASP A OD1 1 
ATOM   201  O  OD2 . ASP A 1 32  ? -10.816 -16.558 10.115  0.26 89.59  ? 295  ASP A OD2 1 
ATOM   202  N  N   . GLN A 1 33  ? -7.821  -13.058 8.894   0.26 100.09 ? 296  GLN A N   1 
ATOM   203  C  CA  . GLN A 1 33  ? -6.415  -12.690 8.563   0.26 99.47  ? 296  GLN A CA  1 
ATOM   204  C  C   . GLN A 1 33  ? -5.572  -13.957 8.352   0.26 99.05  ? 296  GLN A C   1 
ATOM   205  O  O   . GLN A 1 33  ? -4.487  -13.838 7.745   0.26 95.92  ? 296  GLN A O   1 
ATOM   206  C  CB  . GLN A 1 33  ? -5.822  -11.807 9.665   0.26 97.90  ? 296  GLN A CB  1 
ATOM   207  C  CG  . GLN A 1 33  ? -6.350  -10.377 9.651   0.26 96.84  ? 296  GLN A CG  1 
ATOM   208  C  CD  . GLN A 1 33  ? -5.745  -9.531  8.555   0.26 96.62  ? 296  GLN A CD  1 
ATOM   209  O  OE1 . GLN A 1 33  ? -4.656  -9.807  8.056   0.26 95.30  ? 296  GLN A OE1 1 
ATOM   210  N  NE2 . GLN A 1 33  ? -6.449  -8.476  8.175   0.26 95.73  ? 296  GLN A NE2 1 
ATOM   211  N  N   . ASP A 1 34  ? -6.043  -15.111 8.841   0.26 98.55  ? 297  ASP A N   1 
ATOM   212  C  CA  . ASP A 1 34  ? -5.423  -16.445 8.610   0.26 99.27  ? 297  ASP A CA  1 
ATOM   213  C  C   . ASP A 1 34  ? -6.261  -17.202 7.571   0.26 100.72 ? 297  ASP A C   1 
ATOM   214  O  O   . ASP A 1 34  ? -7.013  -18.119 7.964   0.26 102.72 ? 297  ASP A O   1 
ATOM   215  C  CB  . ASP A 1 34  ? -5.272  -17.228 9.918   0.26 97.90  ? 297  ASP A CB  1 
ATOM   216  C  CG  . ASP A 1 34  ? -4.085  -16.798 10.765  0.26 97.27  ? 297  ASP A CG  1 
ATOM   217  O  OD1 . ASP A 1 34  ? -3.860  -15.575 10.889  0.26 96.29  ? 297  ASP A OD1 1 
ATOM   218  O  OD2 . ASP A 1 34  ? -3.391  -17.691 11.290  0.26 93.40  ? 297  ASP A OD2 1 
ATOM   219  N  N   . HIS A 1 35  ? -6.143  -16.809 6.297   0.26 99.20  ? 298  HIS A N   1 
ATOM   220  C  CA  . HIS A 1 35  ? -6.781  -17.466 5.124   0.26 97.03  ? 298  HIS A CA  1 
ATOM   221  C  C   . HIS A 1 35  ? -5.686  -18.004 4.205   0.26 96.27  ? 298  HIS A C   1 
ATOM   222  O  O   . HIS A 1 35  ? -4.718  -17.302 3.919   0.26 95.55  ? 298  HIS A O   1 
ATOM   223  C  CB  . HIS A 1 35  ? -7.744  -16.498 4.415   0.26 95.10  ? 298  HIS A CB  1 
ATOM   224  C  CG  . HIS A 1 35  ? -7.084  -15.307 3.803   0.26 93.32  ? 298  HIS A CG  1 
ATOM   225  N  ND1 . HIS A 1 35  ? -6.889  -14.131 4.500   0.26 93.49  ? 298  HIS A ND1 1 
ATOM   226  C  CD2 . HIS A 1 35  ? -6.582  -15.102 2.565   0.26 91.89  ? 298  HIS A CD2 1 
ATOM   227  C  CE1 . HIS A 1 35  ? -6.293  -13.253 3.718   0.26 93.75  ? 298  HIS A CE1 1 
ATOM   228  N  NE2 . HIS A 1 35  ? -6.093  -13.824 2.526   0.26 92.54  ? 298  HIS A NE2 1 
ATOM   229  N  N   . PRO A 1 36  ? -5.797  -19.261 3.714   0.26 93.66  ? 299  PRO A N   1 
ATOM   230  C  CA  . PRO A 1 36  ? -4.709  -19.898 2.967   0.26 93.23  ? 299  PRO A CA  1 
ATOM   231  C  C   . PRO A 1 36  ? -4.568  -19.481 1.493   0.26 94.63  ? 299  PRO A C   1 
ATOM   232  O  O   . PRO A 1 36  ? -3.772  -20.094 0.799   0.26 95.74  ? 299  PRO A O   1 
ATOM   233  C  CB  . PRO A 1 36  ? -5.097  -21.383 3.050   0.26 93.50  ? 299  PRO A CB  1 
ATOM   234  C  CG  . PRO A 1 36  ? -6.609  -21.359 3.037   0.26 93.72  ? 299  PRO A CG  1 
ATOM   235  C  CD  . PRO A 1 36  ? -6.968  -20.141 3.862   0.26 93.60  ? 299  PRO A CD  1 
ATOM   236  N  N   . TYR A 1 37  ? -5.306  -18.456 1.051   0.26 94.10  ? 300  TYR A N   1 
ATOM   237  C  CA  . TYR A 1 37  ? -5.445  -18.083 -0.383  0.26 91.39  ? 300  TYR A CA  1 
ATOM   238  C  C   . TYR A 1 37  ? -4.389  -17.036 -0.750  0.26 91.79  ? 300  TYR A C   1 
ATOM   239  O  O   . TYR A 1 37  ? -4.348  -15.969 -0.104  0.26 91.20  ? 300  TYR A O   1 
ATOM   240  C  CB  . TYR A 1 37  ? -6.868  -17.597 -0.668  0.26 88.42  ? 300  TYR A CB  1 
ATOM   241  C  CG  . TYR A 1 37  ? -7.937  -18.488 -0.090  0.26 84.51  ? 300  TYR A CG  1 
ATOM   242  C  CD1 . TYR A 1 37  ? -8.173  -19.750 -0.612  0.26 82.91  ? 300  TYR A CD1 1 
ATOM   243  C  CD2 . TYR A 1 37  ? -8.689  -18.088 1.003   0.26 82.11  ? 300  TYR A CD2 1 
ATOM   244  C  CE1 . TYR A 1 37  ? -9.139  -20.585 -0.075  0.26 80.99  ? 300  TYR A CE1 1 
ATOM   245  C  CE2 . TYR A 1 37  ? -9.660  -18.911 1.551   0.26 79.77  ? 300  TYR A CE2 1 
ATOM   246  C  CZ  . TYR A 1 37  ? -9.887  -20.164 1.010   0.26 79.01  ? 300  TYR A CZ  1 
ATOM   247  O  OH  . TYR A 1 37  ? -10.841 -20.980 1.545   0.26 81.18  ? 300  TYR A OH  1 
ATOM   248  N  N   . LYS A 1 38  ? -3.562  -17.351 -1.754  1.00 92.35  ? 301  LYS A N   1 
ATOM   249  C  CA  . LYS A 1 38  ? -2.556  -16.411 -2.324  1.00 102.72 ? 301  LYS A CA  1 
ATOM   250  C  C   . LYS A 1 38  ? -3.004  -16.002 -3.736  1.00 102.36 ? 301  LYS A C   1 
ATOM   251  O  O   . LYS A 1 38  ? -2.894  -14.801 -4.050  1.00 111.74 ? 301  LYS A O   1 
ATOM   252  C  CB  . LYS A 1 38  ? -1.154  -17.038 -2.347  1.00 107.39 ? 301  LYS A CB  1 
ATOM   253  C  CG  . LYS A 1 38  ? -0.026  -16.124 -2.827  1.00 105.71 ? 301  LYS A CG  1 
ATOM   254  C  CD  . LYS A 1 38  ? 0.208   -14.900 -1.949  1.00 107.80 ? 301  LYS A CD  1 
ATOM   255  C  CE  . LYS A 1 38  ? 0.797   -13.716 -2.691  1.00 113.72 ? 301  LYS A CE  1 
ATOM   256  N  NZ  . LYS A 1 38  ? 2.280   -13.756 -2.714  1.00 115.04 ? 301  LYS A NZ  1 
ATOM   257  N  N   . THR A 1 39  ? -3.488  -16.954 -4.548  1.00 105.64 ? 302  THR A N   1 
ATOM   258  C  CA  . THR A 1 39  ? -3.853  -16.737 -5.978  1.00 104.32 ? 302  THR A CA  1 
ATOM   259  C  C   . THR A 1 39  ? -5.368  -16.549 -6.139  1.00 100.43 ? 302  THR A C   1 
ATOM   260  O  O   . THR A 1 39  ? -5.758  -16.046 -7.205  1.00 101.38 ? 302  THR A O   1 
ATOM   261  C  CB  . THR A 1 39  ? -3.380  -17.886 -6.878  1.00 97.17  ? 302  THR A CB  1 
ATOM   262  O  OG1 . THR A 1 39  ? -4.072  -19.056 -6.445  1.00 95.30  ? 302  THR A OG1 1 
ATOM   263  C  CG2 . THR A 1 39  ? -1.884  -18.111 -6.839  1.00 93.55  ? 302  THR A CG2 1 
ATOM   264  N  N   . TRP A 1 40  ? -6.177  -16.978 -5.162  1.00 85.61  ? 303  TRP A N   1 
ATOM   265  C  CA  . TRP A 1 40  ? -7.626  -16.667 -5.087  1.00 82.34  ? 303  TRP A CA  1 
ATOM   266  C  C   . TRP A 1 40  ? -7.812  -15.423 -4.220  1.00 87.04  ? 303  TRP A C   1 
ATOM   267  O  O   . TRP A 1 40  ? -7.311  -15.416 -3.086  1.00 104.51 ? 303  TRP A O   1 
ATOM   268  C  CB  . TRP A 1 40  ? -8.403  -17.813 -4.446  1.00 85.12  ? 303  TRP A CB  1 
ATOM   269  C  CG  . TRP A 1 40  ? -8.632  -19.022 -5.290  1.00 85.47  ? 303  TRP A CG  1 
ATOM   270  C  CD1 . TRP A 1 40  ? -7.819  -20.106 -5.398  1.00 88.38  ? 303  TRP A CD1 1 
ATOM   271  C  CD2 . TRP A 1 40  ? -9.805  -19.321 -6.060  1.00 89.01  ? 303  TRP A CD2 1 
ATOM   272  N  NE1 . TRP A 1 40  ? -8.391  -21.048 -6.205  1.00 96.03  ? 303  TRP A NE1 1 
ATOM   273  C  CE2 . TRP A 1 40  ? -9.617  -20.602 -6.617  1.00 99.28  ? 303  TRP A CE2 1 
ATOM   274  C  CE3 . TRP A 1 40  ? -10.993 -18.636 -6.330  1.00 87.08  ? 303  TRP A CE3 1 
ATOM   275  C  CZ2 . TRP A 1 40  ? -10.565 -21.200 -7.448  1.00 102.21 ? 303  TRP A CZ2 1 
ATOM   276  C  CZ3 . TRP A 1 40  ? -11.933 -19.230 -7.141  1.00 93.07  ? 303  TRP A CZ3 1 
ATOM   277  C  CH2 . TRP A 1 40  ? -11.722 -20.495 -7.689  1.00 94.57  ? 303  TRP A CH2 1 
ATOM   278  N  N   . ALA A 1 41  ? -8.516  -14.412 -4.740  0.26 86.50  ? 304  ALA A N   1 
ATOM   279  C  CA  . ALA A 1 41  ? -8.951  -13.208 -3.991  0.26 84.06  ? 304  ALA A CA  1 
ATOM   280  C  C   . ALA A 1 41  ? -9.952  -13.637 -2.912  0.26 82.65  ? 304  ALA A C   1 
ATOM   281  O  O   . ALA A 1 41  ? -10.909 -14.352 -3.254  0.26 81.32  ? 304  ALA A O   1 
ATOM   282  C  CB  . ALA A 1 41  ? -9.550  -12.189 -4.931  0.26 82.60  ? 304  ALA A CB  1 
ATOM   283  N  N   . TYR A 1 42  ? -9.721  -13.221 -1.662  1.00 82.99  ? 305  TYR A N   1 
ATOM   284  C  CA  . TYR A 1 42  ? -10.508 -13.648 -0.475  1.00 82.18  ? 305  TYR A CA  1 
ATOM   285  C  C   . TYR A 1 42  ? -11.284 -12.459 0.093   1.00 82.88  ? 305  TYR A C   1 
ATOM   286  O  O   . TYR A 1 42  ? -10.683 -11.376 0.264   1.00 87.75  ? 305  TYR A O   1 
ATOM   287  C  CB  . TYR A 1 42  ? -9.564  -14.167 0.603   1.00 80.63  ? 305  TYR A CB  1 
ATOM   288  C  CG  . TYR A 1 42  ? -10.233 -14.313 1.937   1.00 75.16  ? 305  TYR A CG  1 
ATOM   289  C  CD1 . TYR A 1 42  ? -10.877 -15.490 2.261   1.00 71.60  ? 305  TYR A CD1 1 
ATOM   290  C  CD2 . TYR A 1 42  ? -10.231 -13.277 2.857   1.00 75.25  ? 305  TYR A CD2 1 
ATOM   291  C  CE1 . TYR A 1 42  ? -11.498 -15.651 3.485   1.00 78.80  ? 305  TYR A CE1 1 
ATOM   292  C  CE2 . TYR A 1 42  ? -10.871 -13.410 4.077   1.00 75.49  ? 305  TYR A CE2 1 
ATOM   293  C  CZ  . TYR A 1 42  ? -11.500 -14.605 4.389   1.00 80.47  ? 305  TYR A CZ  1 
ATOM   294  O  OH  . TYR A 1 42  ? -12.144 -14.772 5.578   1.00 78.65  ? 305  TYR A OH  1 
ATOM   295  N  N   . HIS A 1 43  ? -12.562 -12.667 0.418   1.00 81.73  ? 306  HIS A N   1 
ATOM   296  C  CA  . HIS A 1 43  ? -13.534 -11.565 0.635   1.00 78.51  ? 306  HIS A CA  1 
ATOM   297  C  C   . HIS A 1 43  ? -14.102 -11.590 2.055   1.00 76.07  ? 306  HIS A C   1 
ATOM   298  O  O   . HIS A 1 43  ? -14.423 -10.486 2.537   1.00 80.23  ? 306  HIS A O   1 
ATOM   299  C  CB  . HIS A 1 43  ? -14.618 -11.595 -0.452  1.00 75.05  ? 306  HIS A CB  1 
ATOM   300  C  CG  . HIS A 1 43  ? -14.124 -11.092 -1.764  1.00 67.67  ? 306  HIS A CG  1 
ATOM   301  N  ND1 . HIS A 1 43  ? -13.932 -11.923 -2.851  1.00 65.29  ? 306  HIS A ND1 1 
ATOM   302  C  CD2 . HIS A 1 43  ? -13.755 -9.851  -2.159  1.00 70.93  ? 306  HIS A CD2 1 
ATOM   303  C  CE1 . HIS A 1 43  ? -13.480 -11.201 -3.868  1.00 64.53  ? 306  HIS A CE1 1 
ATOM   304  N  NE2 . HIS A 1 43  ? -13.369 -9.929  -3.475  1.00 66.82  ? 306  HIS A NE2 1 
ATOM   305  N  N   . GLY A 1 44  ? -14.247 -12.769 2.674   1.00 69.69  ? 307  GLY A N   1 
ATOM   306  C  CA  . GLY A 1 44  ? -14.773 -12.901 4.050   1.00 68.42  ? 307  GLY A CA  1 
ATOM   307  C  C   . GLY A 1 44  ? -15.367 -14.271 4.310   1.00 69.41  ? 307  GLY A C   1 
ATOM   308  O  O   . GLY A 1 44  ? -15.210 -15.140 3.432   1.00 71.29  ? 307  GLY A O   1 
ATOM   309  N  N   . SER A 1 45  ? -16.029 -14.462 5.465   1.00 72.06  ? 308  SER A N   1 
ATOM   310  C  CA  . SER A 1 45  ? -16.522 -15.783 5.953   1.00 80.17  ? 308  SER A CA  1 
ATOM   311  C  C   . SER A 1 45  ? -17.752 -15.602 6.853   1.00 88.25  ? 308  SER A C   1 
ATOM   312  O  O   . SER A 1 45  ? -17.846 -14.553 7.474   1.00 95.55  ? 308  SER A O   1 
ATOM   313  C  CB  . SER A 1 45  ? -15.437 -16.552 6.693   1.00 79.25  ? 308  SER A CB  1 
ATOM   314  O  OG  . SER A 1 45  ? -14.124 -16.139 6.311   1.00 75.65  ? 308  SER A OG  1 
ATOM   315  N  N   . TYR A 1 46  ? -18.631 -16.610 6.922   1.00 96.54  ? 309  TYR A N   1 
ATOM   316  C  CA  . TYR A 1 46  ? -19.813 -16.713 7.827   1.00 100.64 ? 309  TYR A CA  1 
ATOM   317  C  C   . TYR A 1 46  ? -19.838 -18.135 8.423   1.00 106.75 ? 309  TYR A C   1 
ATOM   318  O  O   . TYR A 1 46  ? -18.810 -18.814 8.307   1.00 113.67 ? 309  TYR A O   1 
ATOM   319  C  CB  . TYR A 1 46  ? -21.088 -16.298 7.078   1.00 101.29 ? 309  TYR A CB  1 
ATOM   320  C  CG  . TYR A 1 46  ? -21.495 -17.184 5.924   1.00 98.35  ? 309  TYR A CG  1 
ATOM   321  C  CD1 . TYR A 1 46  ? -22.327 -18.277 6.128   1.00 103.63 ? 309  TYR A CD1 1 
ATOM   322  C  CD2 . TYR A 1 46  ? -21.079 -16.924 4.624   1.00 92.20  ? 309  TYR A CD2 1 
ATOM   323  C  CE1 . TYR A 1 46  ? -22.718 -19.101 5.083   1.00 107.80 ? 309  TYR A CE1 1 
ATOM   324  C  CE2 . TYR A 1 46  ? -21.463 -17.738 3.566   1.00 92.42  ? 309  TYR A CE2 1 
ATOM   325  C  CZ  . TYR A 1 46  ? -22.283 -18.834 3.796   1.00 101.29 ? 309  TYR A CZ  1 
ATOM   326  O  OH  . TYR A 1 46  ? -22.676 -19.664 2.784   1.00 92.64  ? 309  TYR A OH  1 
ATOM   327  N  N   . GLU A 1 47  ? -20.952 -18.579 9.023   1.00 114.60 ? 310  GLU A N   1 
ATOM   328  C  CA  . GLU A 1 47  ? -21.024 -19.790 9.897   1.00 119.65 ? 310  GLU A CA  1 
ATOM   329  C  C   . GLU A 1 47  ? -21.802 -20.936 9.218   1.00 127.63 ? 310  GLU A C   1 
ATOM   330  O  O   . GLU A 1 47  ? -22.924 -20.682 8.720   1.00 129.39 ? 310  GLU A O   1 
ATOM   331  C  CB  . GLU A 1 47  ? -21.651 -19.376 11.234  1.00 128.56 ? 310  GLU A CB  1 
ATOM   332  C  CG  . GLU A 1 47  ? -21.531 -20.415 12.340  1.00 130.28 ? 310  GLU A CG  1 
ATOM   333  C  CD  . GLU A 1 47  ? -21.497 -19.851 13.754  1.00 133.12 ? 310  GLU A CD  1 
ATOM   334  O  OE1 . GLU A 1 47  ? -22.461 -20.093 14.518  1.00 134.74 ? 310  GLU A OE1 1 
ATOM   335  O  OE2 . GLU A 1 47  ? -20.498 -19.179 14.095  1.00 129.82 ? 310  GLU A OE2 1 
ATOM   336  N  N   . THR A 1 48  ? -21.241 -22.160 9.240   1.00 128.48 ? 311  THR A N   1 
ATOM   337  C  CA  . THR A 1 48  ? -21.809 -23.413 8.649   1.00 122.45 ? 311  THR A CA  1 
ATOM   338  C  C   . THR A 1 48  ? -21.156 -24.644 9.306   1.00 122.32 ? 311  THR A C   1 
ATOM   339  O  O   . THR A 1 48  ? -20.251 -24.446 10.137  1.00 112.92 ? 311  THR A O   1 
ATOM   340  C  CB  . THR A 1 48  ? -21.623 -23.423 7.124   1.00 115.56 ? 311  THR A CB  1 
ATOM   341  O  OG1 . THR A 1 48  ? -20.366 -22.807 6.830   1.00 110.20 ? 311  THR A OG1 1 
ATOM   342  C  CG2 . THR A 1 48  ? -22.734 -22.710 6.383   1.00 116.06 ? 311  THR A CG2 1 
ATOM   343  N  N   . SER A 1 56  ? -18.316 -43.334 -1.446  1.00 96.33  ? 319  SER A N   1 
ATOM   344  C  CA  . SER A 1 56  ? -18.687 -44.482 -2.311  1.00 86.15  ? 319  SER A CA  1 
ATOM   345  C  C   . SER A 1 56  ? -19.105 -45.682 -1.448  1.00 82.88  ? 319  SER A C   1 
ATOM   346  O  O   . SER A 1 56  ? -18.344 -46.042 -0.523  1.00 70.66  ? 319  SER A O   1 
ATOM   347  C  CB  . SER A 1 56  ? -17.526 -44.857 -3.197  1.00 94.14  ? 319  SER A CB  1 
ATOM   348  O  OG  . SER A 1 56  ? -16.602 -45.697 -2.500  1.00 84.67  ? 319  SER A OG  1 
ATOM   349  N  N   . MET A 1 57  ? -20.214 -46.334 -1.815  1.00 65.74  ? 320  MET A N   1 
ATOM   350  C  CA  . MET A 1 57  ? -20.721 -47.586 -1.192  1.00 54.48  ? 320  MET A CA  1 
ATOM   351  C  C   . MET A 1 57  ? -20.488 -48.780 -2.136  1.00 39.44  ? 320  MET A C   1 
ATOM   352  O  O   . MET A 1 57  ? -20.425 -48.594 -3.348  1.00 42.05  ? 320  MET A O   1 
ATOM   353  C  CB  . MET A 1 57  ? -22.214 -47.397 -0.926  1.00 65.43  ? 320  MET A CB  1 
ATOM   354  C  CG  . MET A 1 57  ? -22.537 -45.975 -0.445  1.00 72.80  ? 320  MET A CG  1 
ATOM   355  S  SD  . MET A 1 57  ? -21.753 -45.641 1.171   1.00 71.29  ? 320  MET A SD  1 
ATOM   356  C  CE  . MET A 1 57  ? -22.908 -46.473 2.262   1.00 63.99  ? 320  MET A CE  1 
ATOM   357  N  N   . VAL A 1 58  ? -20.423 -49.990 -1.623  1.00 35.41  ? 321  VAL A N   1 
ATOM   358  C  CA  . VAL A 1 58  ? -20.260 -51.204 -2.475  1.00 36.37  ? 321  VAL A CA  1 
ATOM   359  C  C   . VAL A 1 58  ? -21.614 -51.738 -2.929  1.00 36.73  ? 321  VAL A C   1 
ATOM   360  O  O   . VAL A 1 58  ? -22.471 -51.950 -2.096  1.00 38.68  ? 321  VAL A O   1 
ATOM   361  C  CB  . VAL A 1 58  ? -19.494 -52.324 -1.760  1.00 37.00  ? 321  VAL A CB  1 
ATOM   362  C  CG1 . VAL A 1 58  ? -19.348 -53.570 -2.650  1.00 34.72  ? 321  VAL A CG1 1 
ATOM   363  C  CG2 . VAL A 1 58  ? -18.157 -51.819 -1.306  1.00 40.43  ? 321  VAL A CG2 1 
ATOM   364  N  N   . ASN A 1 59  ? -21.700 -52.047 -4.215  1.00 28.63  ? 322  ASN A N   1 
ATOM   365  C  CA  . ASN A 1 59  ? -22.795 -52.767 -4.862  1.00 29.04  ? 322  ASN A CA  1 
ATOM   366  C  C   . ASN A 1 59  ? -22.653 -54.227 -4.515  1.00 28.42  ? 322  ASN A C   1 
ATOM   367  O  O   . ASN A 1 59  ? -21.772 -54.867 -5.118  1.00 33.15  ? 322  ASN A O   1 
ATOM   368  C  CB  . ASN A 1 59  ? -22.743 -52.540 -6.372  1.00 29.13  ? 322  ASN A CB  1 
ATOM   369  C  CG  . ASN A 1 59  ? -23.953 -53.143 -7.046  1.00 29.65  ? 322  ASN A CG  1 
ATOM   370  O  OD1 . ASN A 1 59  ? -24.390 -54.240 -6.680  1.00 29.31  ? 322  ASN A OD1 1 
ATOM   371  N  ND2 . ASN A 1 59  ? -24.527 -52.410 -7.979  1.00 32.51  ? 322  ASN A ND2 1 
ATOM   372  N  N   . GLY A 1 60  ? -23.510 -54.753 -3.648  1.00 31.07  ? 323  GLY A N   1 
ATOM   373  C  CA  . GLY A 1 60  ? -23.405 -56.154 -3.170  1.00 31.09  ? 323  GLY A CA  1 
ATOM   374  C  C   . GLY A 1 60  ? -23.800 -57.162 -4.253  1.00 33.53  ? 323  GLY A C   1 
ATOM   375  O  O   . GLY A 1 60  ? -23.304 -58.313 -4.317  1.00 31.82  ? 323  GLY A O   1 
ATOM   376  N  N   . VAL A 1 61  ? -24.666 -56.781 -5.162  1.00 35.01  ? 324  VAL A N   1 
ATOM   377  C  CA  . VAL A 1 61  ? -25.045 -57.745 -6.225  1.00 34.48  ? 324  VAL A CA  1 
ATOM   378  C  C   . VAL A 1 61  ? -23.774 -58.059 -7.020  1.00 32.18  ? 324  VAL A C   1 
ATOM   379  O  O   . VAL A 1 61  ? -23.455 -59.241 -7.188  1.00 31.57  ? 324  VAL A O   1 
ATOM   380  C  CB  . VAL A 1 61  ? -26.231 -57.204 -7.040  1.00 30.64  ? 324  VAL A CB  1 
ATOM   381  C  CG1 . VAL A 1 61  ? -26.491 -57.999 -8.294  1.00 30.15  ? 324  VAL A CG1 1 
ATOM   382  C  CG2 . VAL A 1 61  ? -27.449 -57.204 -6.143  1.00 32.91  ? 324  VAL A CG2 1 
ATOM   383  N  N   . VAL A 1 62  ? -23.049 -57.030 -7.456  1.00 31.58  ? 325  VAL A N   1 
ATOM   384  C  CA  . VAL A 1 62  ? -21.846 -57.213 -8.319  1.00 29.61  ? 325  VAL A CA  1 
ATOM   385  C  C   . VAL A 1 62  ? -20.764 -57.931 -7.504  1.00 30.25  ? 325  VAL A C   1 
ATOM   386  O  O   . VAL A 1 62  ? -20.180 -58.857 -8.026  1.00 27.60  ? 325  VAL A O   1 
ATOM   387  C  CB  . VAL A 1 62  ? -21.303 -55.908 -8.916  1.00 28.42  ? 325  VAL A CB  1 
ATOM   388  C  CG1 . VAL A 1 62  ? -20.018 -56.191 -9.647  1.00 26.44  ? 325  VAL A CG1 1 
ATOM   389  C  CG2 . VAL A 1 62  ? -22.305 -55.254 -9.862  1.00 27.62  ? 325  VAL A CG2 1 
ATOM   390  N  N   . ARG A 1 63  ? -20.538 -57.523 -6.261  1.00 27.20  ? 326  ARG A N   1 
ATOM   391  C  CA  . ARG A 1 63  ? -19.460 -58.110 -5.444  1.00 30.32  ? 326  ARG A CA  1 
ATOM   392  C  C   . ARG A 1 63  ? -19.741 -59.606 -5.186  1.00 31.43  ? 326  ARG A C   1 
ATOM   393  O  O   . ARG A 1 63  ? -18.751 -60.417 -5.198  1.00 29.94  ? 326  ARG A O   1 
ATOM   394  C  CB  . ARG A 1 63  ? -19.217 -57.319 -4.162  1.00 28.12  ? 326  ARG A CB  1 
ATOM   395  C  CG  . ARG A 1 63  ? -18.206 -58.014 -3.259  1.00 27.92  ? 326  ARG A CG  1 
ATOM   396  C  CD  . ARG A 1 63  ? -17.519 -57.138 -2.248  1.00 26.52  ? 326  ARG A CD  1 
ATOM   397  N  NE  . ARG A 1 63  ? -18.447 -56.596 -1.269  1.00 29.47  ? 326  ARG A NE  1 
ATOM   398  C  CZ  . ARG A 1 63  ? -18.078 -55.736 -0.311  1.00 34.62  ? 326  ARG A CZ  1 
ATOM   399  N  NH1 . ARG A 1 63  ? -16.801 -55.393 -0.197  1.00 32.32  ? 326  ARG A NH1 1 
ATOM   400  N  NH2 . ARG A 1 63  ? -18.969 -55.203 0.519   1.00 30.11  ? 326  ARG A NH2 1 
ATOM   401  N  N   . LEU A 1 64  ? -20.988 -59.998 -4.957  1.00 27.66  ? 327  LEU A N   1 
ATOM   402  C  CA  . LEU A 1 64  ? -21.280 -61.419 -4.626  1.00 28.61  ? 327  LEU A CA  1 
ATOM   403  C  C   . LEU A 1 64  ? -21.040 -62.259 -5.879  1.00 27.57  ? 327  LEU A C   1 
ATOM   404  O  O   . LEU A 1 64  ? -20.730 -63.455 -5.727  1.00 31.25  ? 327  LEU A O   1 
ATOM   405  C  CB  . LEU A 1 64  ? -22.712 -61.611 -4.102  1.00 29.74  ? 327  LEU A CB  1 
ATOM   406  C  CG  . LEU A 1 64  ? -22.953 -61.286 -2.630  1.00 30.80  ? 327  LEU A CG  1 
ATOM   407  C  CD1 . LEU A 1 64  ? -24.419 -61.516 -2.248  1.00 35.63  ? 327  LEU A CD1 1 
ATOM   408  C  CD2 . LEU A 1 64  ? -22.110 -62.132 -1.703  1.00 35.24  ? 327  LEU A CD2 1 
ATOM   409  N  N   . LEU A 1 65  ? -21.107 -61.672 -7.074  1.00 28.36  ? 328  LEU A N   1 
ATOM   410  C  CA  . LEU A 1 65  ? -20.911 -62.455 -8.339  1.00 28.78  ? 328  LEU A CA  1 
ATOM   411  C  C   . LEU A 1 65  ? -19.495 -62.276 -8.897  1.00 28.78  ? 328  LEU A C   1 
ATOM   412  O  O   . LEU A 1 65  ? -19.225 -62.822 -10.001 1.00 28.01  ? 328  LEU A O   1 
ATOM   413  C  CB  . LEU A 1 65  ? -22.004 -62.105 -9.355  1.00 30.00  ? 328  LEU A CB  1 
ATOM   414  C  CG  . LEU A 1 65  ? -23.430 -62.390 -8.856  1.00 30.52  ? 328  LEU A CG  1 
ATOM   415  C  CD1 . LEU A 1 65  ? -24.498 -61.756 -9.733  1.00 32.69  ? 328  LEU A CD1 1 
ATOM   416  C  CD2 . LEU A 1 65  ? -23.666 -63.867 -8.746  1.00 33.36  ? 328  LEU A CD2 1 
ATOM   417  N  N   . THR A 1 66  ? -18.581 -61.645 -8.143  1.00 26.06  ? 329  THR A N   1 
ATOM   418  C  CA  . THR A 1 66  ? -17.161 -61.445 -8.555  1.00 25.40  ? 329  THR A CA  1 
ATOM   419  C  C   . THR A 1 66  ? -16.263 -61.795 -7.353  1.00 24.52  ? 329  THR A C   1 
ATOM   420  O  O   . THR A 1 66  ? -15.272 -61.066 -7.053  1.00 31.41  ? 329  THR A O   1 
ATOM   421  C  CB  . THR A 1 66  ? -16.915 -60.027 -9.108  1.00 25.20  ? 329  THR A CB  1 
ATOM   422  O  OG1 . THR A 1 66  ? -17.343 -59.013 -8.183  1.00 23.09  ? 329  THR A OG1 1 
ATOM   423  C  CG2 . THR A 1 66  ? -17.543 -59.820 -10.465 1.00 25.69  ? 329  THR A CG2 1 
ATOM   424  N  N   . LYS A 1 67  ? -16.467 -62.967 -6.785  1.00 24.12  ? 330  LYS A N   1 
ATOM   425  C  CA  . LYS A 1 67  ? -15.814 -63.391 -5.526  1.00 26.86  ? 330  LYS A CA  1 
ATOM   426  C  C   . LYS A 1 67  ? -14.279 -63.484 -5.669  1.00 28.26  ? 330  LYS A C   1 
ATOM   427  O  O   . LYS A 1 67  ? -13.581 -63.117 -4.746  1.00 30.46  ? 330  LYS A O   1 
ATOM   428  C  CB  . LYS A 1 67  ? -16.379 -64.727 -5.069  1.00 28.56  ? 330  LYS A CB  1 
ATOM   429  C  CG  . LYS A 1 67  ? -16.032 -65.032 -3.628  1.00 34.18  ? 330  LYS A CG  1 
ATOM   430  C  CD  . LYS A 1 67  ? -16.274 -66.439 -3.211  1.00 37.59  ? 330  LYS A CD  1 
ATOM   431  C  CE  . LYS A 1 67  ? -16.458 -66.491 -1.713  1.00 42.72  ? 330  LYS A CE  1 
ATOM   432  N  NZ  . LYS A 1 67  ? -16.099 -67.832 -1.223  1.00 50.34  ? 330  LYS A NZ  1 
ATOM   433  N  N   . PRO A 1 68  ? -13.691 -64.006 -6.759  1.00 25.17  ? 331  PRO A N   1 
ATOM   434  C  CA  . PRO A 1 68  ? -12.231 -64.056 -6.896  1.00 29.66  ? 331  PRO A CA  1 
ATOM   435  C  C   . PRO A 1 68  ? -11.574 -62.686 -6.672  1.00 32.09  ? 331  PRO A C   1 
ATOM   436  O  O   . PRO A 1 68  ? -10.421 -62.616 -6.217  1.00 26.24  ? 331  PRO A O   1 
ATOM   437  C  CB  . PRO A 1 68  ? -12.020 -64.547 -8.349  1.00 29.06  ? 331  PRO A CB  1 
ATOM   438  C  CG  . PRO A 1 68  ? -13.199 -65.439 -8.540  1.00 30.15  ? 331  PRO A CG  1 
ATOM   439  C  CD  . PRO A 1 68  ? -14.359 -64.662 -7.888  1.00 29.26  ? 331  PRO A CD  1 
ATOM   440  N  N   . TRP A 1 69  ? -12.297 -61.611 -6.967  1.00 25.44  ? 332  TRP A N   1 
ATOM   441  C  CA  . TRP A 1 69  ? -11.714 -60.260 -6.909  1.00 29.60  ? 332  TRP A CA  1 
ATOM   442  C  C   . TRP A 1 69  ? -11.753 -59.715 -5.474  1.00 30.50  ? 332  TRP A C   1 
ATOM   443  O  O   . TRP A 1 69  ? -11.159 -58.675 -5.235  1.00 32.20  ? 332  TRP A O   1 
ATOM   444  C  CB  . TRP A 1 69  ? -12.375 -59.400 -7.976  1.00 29.29  ? 332  TRP A CB  1 
ATOM   445  C  CG  . TRP A 1 69  ? -11.955 -59.849 -9.342  1.00 28.14  ? 332  TRP A CG  1 
ATOM   446  C  CD1 . TRP A 1 69  ? -10.867 -59.390 -10.016 1.00 28.43  ? 332  TRP A CD1 1 
ATOM   447  C  CD2 . TRP A 1 69  ? -12.550 -60.854 -10.184 1.00 28.65  ? 332  TRP A CD2 1 
ATOM   448  N  NE1 . TRP A 1 69  ? -10.734 -60.052 -11.211 1.00 32.08  ? 332  TRP A NE1 1 
ATOM   449  C  CE2 . TRP A 1 69  ? -11.756 -60.932 -11.354 1.00 29.52  ? 332  TRP A CE2 1 
ATOM   450  C  CE3 . TRP A 1 69  ? -13.693 -61.663 -10.101 1.00 31.50  ? 332  TRP A CE3 1 
ATOM   451  C  CZ2 . TRP A 1 69  ? -12.042 -61.790 -12.407 1.00 32.66  ? 332  TRP A CZ2 1 
ATOM   452  C  CZ3 . TRP A 1 69  ? -13.992 -62.498 -11.156 1.00 30.22  ? 332  TRP A CZ3 1 
ATOM   453  C  CH2 . TRP A 1 69  ? -13.169 -62.574 -12.283 1.00 31.83  ? 332  TRP A CH2 1 
ATOM   454  N  N   . ASP A 1 70  ? -12.330 -60.444 -4.524  1.00 28.75  ? 333  ASP A N   1 
ATOM   455  C  CA  . ASP A 1 70  ? -12.375 -60.001 -3.106  1.00 28.43  ? 333  ASP A CA  1 
ATOM   456  C  C   . ASP A 1 70  ? -10.970 -59.908 -2.477  1.00 30.51  ? 333  ASP A C   1 
ATOM   457  O  O   . ASP A 1 70  ? -10.853 -59.259 -1.368  1.00 34.17  ? 333  ASP A O   1 
ATOM   458  C  CB  . ASP A 1 70  ? -13.267 -60.934 -2.290  1.00 31.09  ? 333  ASP A CB  1 
ATOM   459  C  CG  . ASP A 1 70  ? -14.759 -60.779 -2.593  1.00 32.01  ? 333  ASP A CG  1 
ATOM   460  O  OD1 . ASP A 1 70  ? -15.122 -59.894 -3.453  1.00 31.49  ? 333  ASP A OD1 1 
ATOM   461  O  OD2 . ASP A 1 70  ? -15.526 -61.580 -2.014  1.00 28.57  ? 333  ASP A OD2 1 
ATOM   462  N  N   . ILE A 1 71  ? -9.963  -60.579 -3.063  1.00 32.86  ? 334  ILE A N   1 
ATOM   463  C  CA  . ILE A 1 71  ? -8.564  -60.687 -2.541  1.00 29.93  ? 334  ILE A CA  1 
ATOM   464  C  C   . ILE A 1 71  ? -7.559  -59.935 -3.440  1.00 34.54  ? 334  ILE A C   1 
ATOM   465  O  O   . ILE A 1 71  ? -6.315  -59.982 -3.118  1.00 37.43  ? 334  ILE A O   1 
ATOM   466  C  CB  . ILE A 1 71  ? -8.164  -62.164 -2.322  1.00 32.98  ? 334  ILE A CB  1 
ATOM   467  C  CG1 . ILE A 1 71  ? -8.189  -62.998 -3.603  1.00 34.84  ? 334  ILE A CG1 1 
ATOM   468  C  CG2 . ILE A 1 71  ? -8.996  -62.822 -1.249  1.00 30.03  ? 334  ILE A CG2 1 
ATOM   469  C  CD1 . ILE A 1 71  ? -7.523  -64.314 -3.440  1.00 43.12  ? 334  ILE A CD1 1 
ATOM   470  N  N   . ILE A 1 72  ? -8.018  -59.248 -4.499  1.00 31.73  ? 335  ILE A N   1 
ATOM   471  C  CA  . ILE A 1 72  ? -7.208  -58.411 -5.419  1.00 30.49  ? 335  ILE A CA  1 
ATOM   472  C  C   . ILE A 1 72  ? -7.233  -56.971 -4.926  1.00 36.24  ? 335  ILE A C   1 
ATOM   473  O  O   . ILE A 1 72  ? -8.217  -56.246 -5.106  1.00 36.11  ? 335  ILE A O   1 
ATOM   474  C  CB  . ILE A 1 72  ? -7.765  -58.504 -6.846  1.00 35.36  ? 335  ILE A CB  1 
ATOM   475  C  CG1 . ILE A 1 72  ? -7.905  -59.949 -7.340  1.00 35.39  ? 335  ILE A CG1 1 
ATOM   476  C  CG2 . ILE A 1 72  ? -6.978  -57.623 -7.819  1.00 35.21  ? 335  ILE A CG2 1 
ATOM   477  C  CD1 . ILE A 1 72  ? -6.646  -60.731 -7.328  1.00 39.56  ? 335  ILE A CD1 1 
ATOM   478  N  N   . PRO A 1 73  ? -6.141  -56.495 -4.294  1.00 39.12  ? 336  PRO A N   1 
ATOM   479  C  CA  . PRO A 1 73  ? -6.074  -55.130 -3.755  1.00 36.65  ? 336  PRO A CA  1 
ATOM   480  C  C   . PRO A 1 73  ? -6.384  -53.997 -4.741  1.00 35.70  ? 336  PRO A C   1 
ATOM   481  O  O   . PRO A 1 73  ? -7.029  -53.077 -4.344  1.00 42.31  ? 336  PRO A O   1 
ATOM   482  C  CB  . PRO A 1 73  ? -4.600  -55.021 -3.346  1.00 42.09  ? 336  PRO A CB  1 
ATOM   483  C  CG  . PRO A 1 73  ? -4.294  -56.448 -2.925  1.00 42.56  ? 336  PRO A CG  1 
ATOM   484  C  CD  . PRO A 1 73  ? -4.919  -57.276 -4.029  1.00 39.93  ? 336  PRO A CD  1 
ATOM   485  N  N   . MET A 1 74  ? -6.021  -54.135 -6.017  1.00 36.33  ? 337  MET A N   1 
ATOM   486  C  CA  . MET A 1 74  ? -6.353  -53.130 -7.065  1.00 37.58  ? 337  MET A CA  1 
ATOM   487  C  C   . MET A 1 74  ? -7.887  -52.999 -7.164  1.00 39.25  ? 337  MET A C   1 
ATOM   488  O  O   . MET A 1 74  ? -8.356  -51.861 -7.306  1.00 39.97  ? 337  MET A O   1 
ATOM   489  C  CB  . MET A 1 74  ? -5.748  -53.529 -8.416  1.00 46.18  ? 337  MET A CB  1 
ATOM   490  C  CG  . MET A 1 74  ? -4.195  -53.517 -8.420  1.00 56.22  ? 337  MET A CG  1 
ATOM   491  S  SD  . MET A 1 74  ? -3.468  -51.846 -8.080  1.00 67.98  ? 337  MET A SD  1 
ATOM   492  C  CE  . MET A 1 74  ? -4.483  -50.838 -9.168  1.00 63.35  ? 337  MET A CE  1 
ATOM   493  N  N   . VAL A 1 75  ? -8.650  -54.089 -6.978  1.00 30.16  ? 338  VAL A N   1 
ATOM   494  C  CA  . VAL A 1 75  ? -10.156 -54.026 -6.981  1.00 29.45  ? 338  VAL A CA  1 
ATOM   495  C  C   . VAL A 1 75  ? -10.669 -53.467 -5.659  1.00 28.26  ? 338  VAL A C   1 
ATOM   496  O  O   . VAL A 1 75  ? -11.372 -52.472 -5.696  1.00 32.72  ? 338  VAL A O   1 
ATOM   497  C  CB  . VAL A 1 75  ? -10.796 -55.385 -7.315  1.00 28.82  ? 338  VAL A CB  1 
ATOM   498  C  CG1 . VAL A 1 75  ? -12.306 -55.395 -7.049  1.00 30.62  ? 338  VAL A CG1 1 
ATOM   499  C  CG2 . VAL A 1 75  ? -10.511 -55.743 -8.767  1.00 26.56  ? 338  VAL A CG2 1 
ATOM   500  N  N   . THR A 1 76  ? -10.299 -54.067 -4.539  1.00 32.40  ? 339  THR A N   1 
ATOM   501  C  CA  . THR A 1 76  ? -10.842 -53.765 -3.192  1.00 35.01  ? 339  THR A CA  1 
ATOM   502  C  C   . THR A 1 76  ? -10.482 -52.338 -2.767  1.00 36.71  ? 339  THR A C   1 
ATOM   503  O  O   . THR A 1 76  ? -11.333 -51.669 -2.123  1.00 40.13  ? 339  THR A O   1 
ATOM   504  C  CB  . THR A 1 76  ? -10.350 -54.788 -2.166  1.00 38.38  ? 339  THR A CB  1 
ATOM   505  O  OG1 . THR A 1 76  ? -8.920  -54.821 -2.087  1.00 41.84  ? 339  THR A OG1 1 
ATOM   506  C  CG2 . THR A 1 76  ? -10.797 -56.183 -2.528  1.00 43.39  ? 339  THR A CG2 1 
ATOM   507  N  N   . GLN A 1 77  ? -9.299  -51.858 -3.105  1.00 37.42  ? 340  GLN A N   1 
ATOM   508  C  CA  . GLN A 1 77  ? -8.849  -50.512 -2.635  1.00 41.77  ? 340  GLN A CA  1 
ATOM   509  C  C   . GLN A 1 77  ? -9.615  -49.410 -3.347  1.00 36.79  ? 340  GLN A C   1 
ATOM   510  O  O   . GLN A 1 77  ? -9.653  -48.339 -2.782  1.00 38.77  ? 340  GLN A O   1 
ATOM   511  C  CB  . GLN A 1 77  ? -7.363  -50.210 -2.872  1.00 43.48  ? 340  GLN A CB  1 
ATOM   512  C  CG  . GLN A 1 77  ? -6.440  -51.323 -2.423  1.00 52.55  ? 340  GLN A CG  1 
ATOM   513  C  CD  . GLN A 1 77  ? -6.047  -51.311 -0.976  1.00 64.50  ? 340  GLN A CD  1 
ATOM   514  O  OE1 . GLN A 1 77  ? -6.606  -50.569 -0.166  1.00 73.87  ? 340  GLN A OE1 1 
ATOM   515  N  NE2 . GLN A 1 77  ? -5.075  -52.158 -0.654  1.00 70.47  ? 340  GLN A NE2 1 
ATOM   516  N  N   . MET A 1 78  ? -10.160 -49.650 -4.545  1.00 38.23  ? 341  MET A N   1 
ATOM   517  C  CA  . MET A 1 78  ? -10.889 -48.605 -5.306  1.00 39.30  ? 341  MET A CA  1 
ATOM   518  C  C   . MET A 1 78  ? -12.089 -48.137 -4.496  1.00 42.08  ? 341  MET A C   1 
ATOM   519  O  O   . MET A 1 78  ? -12.503 -46.986 -4.693  1.00 40.11  ? 341  MET A O   1 
ATOM   520  C  CB  . MET A 1 78  ? -11.392 -49.075 -6.666  1.00 42.77  ? 341  MET A CB  1 
ATOM   521  C  CG  . MET A 1 78  ? -10.300 -49.187 -7.699  1.00 52.79  ? 341  MET A CG  1 
ATOM   522  S  SD  . MET A 1 78  ? -10.934 -49.584 -9.359  1.00 54.94  ? 341  MET A SD  1 
ATOM   523  C  CE  . MET A 1 78  ? -12.134 -48.259 -9.493  1.00 46.09  ? 341  MET A CE  1 
ATOM   524  N  N   . ALA A 1 79  ? -12.635 -48.996 -3.626  1.00 43.17  ? 342  ALA A N   1 
ATOM   525  C  CA  . ALA A 1 79  ? -13.901 -48.717 -2.913  1.00 39.50  ? 342  ALA A CA  1 
ATOM   526  C  C   . ALA A 1 79  ? -13.620 -48.035 -1.574  1.00 42.24  ? 342  ALA A C   1 
ATOM   527  O  O   . ALA A 1 79  ? -14.581 -47.686 -0.935  1.00 38.31  ? 342  ALA A O   1 
ATOM   528  C  CB  . ALA A 1 79  ? -14.662 -50.003 -2.723  1.00 43.81  ? 342  ALA A CB  1 
ATOM   529  N  N   . MET A 1 80  ? -12.359 -47.853 -1.162  1.00 42.87  ? 343  MET A N   1 
ATOM   530  C  CA  . MET A 1 80  ? -12.050 -47.153 0.121   1.00 55.23  ? 343  MET A CA  1 
ATOM   531  C  C   . MET A 1 80  ? -11.894 -45.648 -0.155  1.00 57.52  ? 343  MET A C   1 
ATOM   532  O  O   . MET A 1 80  ? -11.776 -45.283 -1.332  1.00 65.87  ? 343  MET A O   1 
ATOM   533  C  CB  . MET A 1 80  ? -10.780 -47.730 0.763   1.00 51.91  ? 343  MET A CB  1 
ATOM   534  C  CG  . MET A 1 80  ? -10.752 -49.274 0.801   1.00 58.12  ? 343  MET A CG  1 
ATOM   535  S  SD  . MET A 1 80  ? -12.084 -50.117 1.785   1.00 55.36  ? 343  MET A SD  1 
ATOM   536  C  CE  . MET A 1 80  ? -11.698 -49.483 3.426   1.00 52.81  ? 343  MET A CE  1 
ATOM   537  N  N   . THR A 1 81  ? -11.897 -44.805 0.881   1.00 77.10  ? 344  THR A N   1 
ATOM   538  C  CA  . THR A 1 81  ? -11.459 -43.389 0.802   1.00 77.17  ? 344  THR A CA  1 
ATOM   539  C  C   . THR A 1 81  ? -12.116 -42.534 1.869   1.00 74.75  ? 344  THR A C   1 
ATOM   540  O  O   . THR A 1 81  ? -13.352 -42.650 1.983   1.00 86.54  ? 344  THR A O   1 
ATOM   541  N  N   . GLU A 1 94  ? -4.159  -28.205 -3.857  0.26 101.36 ? 357  GLU A N   1 
ATOM   542  C  CA  . GLU A 1 94  ? -2.948  -27.337 -3.852  0.26 101.81 ? 357  GLU A CA  1 
ATOM   543  C  C   . GLU A 1 94  ? -2.579  -26.950 -5.292  0.26 100.90 ? 357  GLU A C   1 
ATOM   544  O  O   . GLU A 1 94  ? -1.653  -26.131 -5.458  0.26 97.08  ? 357  GLU A O   1 
ATOM   545  C  CB  . GLU A 1 94  ? -1.785  -28.044 -3.150  0.26 102.27 ? 357  GLU A CB  1 
ATOM   546  C  CG  . GLU A 1 94  ? -1.929  -28.097 -1.638  0.26 103.55 ? 357  GLU A CG  1 
ATOM   547  C  CD  . GLU A 1 94  ? -3.122  -28.891 -1.132  0.26 104.78 ? 357  GLU A CD  1 
ATOM   548  O  OE1 . GLU A 1 94  ? -4.035  -28.275 -0.544  0.26 102.24 ? 357  GLU A OE1 1 
ATOM   549  O  OE2 . GLU A 1 94  ? -3.132  -30.125 -1.322  0.26 105.94 ? 357  GLU A OE2 1 
ATOM   550  N  N   . LYS A 1 95  ? -3.278  -27.513 -6.286  0.26 101.72 ? 358  LYS A N   1 
ATOM   551  C  CA  . LYS A 1 95  ? -3.088  -27.221 -7.734  0.26 102.16 ? 358  LYS A CA  1 
ATOM   552  C  C   . LYS A 1 95  ? -4.060  -26.120 -8.181  0.26 102.98 ? 358  LYS A C   1 
ATOM   553  O  O   . LYS A 1 95  ? -3.706  -25.371 -9.114  0.26 96.38  ? 358  LYS A O   1 
ATOM   554  C  CB  . LYS A 1 95  ? -3.295  -28.489 -8.567  0.26 102.09 ? 358  LYS A CB  1 
ATOM   555  C  CG  . LYS A 1 95  ? -2.801  -28.398 -10.004 0.26 100.32 ? 358  LYS A CG  1 
ATOM   556  C  CD  . LYS A 1 95  ? -2.669  -29.740 -10.687 0.26 98.42  ? 358  LYS A CD  1 
ATOM   557  C  CE  . LYS A 1 95  ? -1.600  -29.751 -11.759 0.26 98.26  ? 358  LYS A CE  1 
ATOM   558  N  NZ  . LYS A 1 95  ? -1.281  -31.133 -12.187 0.26 98.08  ? 358  LYS A NZ  1 
ATOM   559  N  N   . VAL A 1 96  ? -5.241  -26.038 -7.556  0.26 106.79 ? 359  VAL A N   1 
ATOM   560  C  CA  . VAL A 1 96  ? -6.283  -25.007 -7.852  0.26 109.40 ? 359  VAL A CA  1 
ATOM   561  C  C   . VAL A 1 96  ? -5.753  -23.629 -7.427  0.26 109.84 ? 359  VAL A C   1 
ATOM   562  O  O   . VAL A 1 96  ? -6.102  -22.638 -8.099  0.26 110.26 ? 359  VAL A O   1 
ATOM   563  C  CB  . VAL A 1 96  ? -7.631  -25.340 -7.179  0.26 109.10 ? 359  VAL A CB  1 
ATOM   564  C  CG1 . VAL A 1 96  ? -7.599  -25.136 -5.670  0.26 109.37 ? 359  VAL A CG1 1 
ATOM   565  C  CG2 . VAL A 1 96  ? -8.779  -24.556 -7.800  0.26 108.34 ? 359  VAL A CG2 1 
ATOM   566  N  N   . ASP A 1 97  ? -4.938  -23.576 -6.366  0.26 110.20 ? 360  ASP A N   1 
ATOM   567  C  CA  . ASP A 1 97  ? -4.313  -22.333 -5.837  0.26 111.81 ? 360  ASP A CA  1 
ATOM   568  C  C   . ASP A 1 97  ? -2.930  -22.174 -6.489  0.26 115.69 ? 360  ASP A C   1 
ATOM   569  O  O   . ASP A 1 97  ? -1.914  -22.238 -5.766  0.26 117.84 ? 360  ASP A O   1 
ATOM   570  C  CB  . ASP A 1 97  ? -4.282  -22.355 -4.303  0.26 109.33 ? 360  ASP A CB  1 
ATOM   571  C  CG  . ASP A 1 97  ? -4.460  -20.994 -3.646  0.26 107.57 ? 360  ASP A CG  1 
ATOM   572  O  OD1 . ASP A 1 97  ? -3.918  -20.005 -4.177  0.26 103.28 ? 360  ASP A OD1 1 
ATOM   573  O  OD2 . ASP A 1 97  ? -5.147  -20.934 -2.605  0.26 106.07 ? 360  ASP A OD2 1 
ATOM   574  N  N   . THR A 1 98  ? -2.908  -21.978 -7.814  1.00 119.36 ? 361  THR A N   1 
ATOM   575  C  CA  . THR A 1 98  ? -1.669  -21.793 -8.635  1.00 116.37 ? 361  THR A CA  1 
ATOM   576  C  C   . THR A 1 98  ? -1.964  -20.722 -9.695  1.00 122.14 ? 361  THR A C   1 
ATOM   577  O  O   . THR A 1 98  ? -3.159  -20.427 -9.870  1.00 120.33 ? 361  THR A O   1 
ATOM   578  C  CB  . THR A 1 98  ? -1.233  -23.093 -9.324  1.00 113.39 ? 361  THR A CB  1 
ATOM   579  O  OG1 . THR A 1 98  ? -2.373  -23.627 -10.004 1.00 94.63  ? 361  THR A OG1 1 
ATOM   580  C  CG2 . THR A 1 98  ? -0.660  -24.114 -8.363  1.00 116.47 ? 361  THR A CG2 1 
ATOM   581  N  N   . ARG A 1 99  ? -0.946  -20.185 -10.389 1.00 130.47 ? 362  ARG A N   1 
ATOM   582  C  CA  . ARG A 1 99  ? -1.108  -19.052 -11.353 1.00 128.35 ? 362  ARG A CA  1 
ATOM   583  C  C   . ARG A 1 99  ? -0.213  -19.242 -12.591 1.00 117.64 ? 362  ARG A C   1 
ATOM   584  O  O   . ARG A 1 99  ? 1.021   -19.158 -12.444 1.00 130.10 ? 362  ARG A O   1 
ATOM   585  C  CB  . ARG A 1 99  ? -0.792  -17.723 -10.653 1.00 137.02 ? 362  ARG A CB  1 
ATOM   586  C  CG  . ARG A 1 99  ? -1.672  -16.554 -11.081 1.00 138.30 ? 362  ARG A CG  1 
ATOM   587  C  CD  . ARG A 1 99  ? -0.925  -15.230 -11.050 1.00 143.60 ? 362  ARG A CD  1 
ATOM   588  N  NE  . ARG A 1 99  ? -0.331  -14.891 -12.344 1.00 147.36 ? 362  ARG A NE  1 
ATOM   589  C  CZ  . ARG A 1 99  ? 0.810   -14.220 -12.529 1.00 139.12 ? 362  ARG A CZ  1 
ATOM   590  N  NH1 . ARG A 1 99  ? 1.534   -13.807 -11.500 1.00 138.18 ? 362  ARG A NH1 1 
ATOM   591  N  NH2 . ARG A 1 99  ? 1.234   -13.976 -13.759 1.00 129.83 ? 362  ARG A NH2 1 
ATOM   592  N  N   . THR A 1 100 ? -0.817  -19.458 -13.769 1.00 107.49 ? 363  THR A N   1 
ATOM   593  C  CA  . THR A 1 100 ? -0.130  -19.529 -15.092 1.00 102.72 ? 363  THR A CA  1 
ATOM   594  C  C   . THR A 1 100 ? 0.151   -18.102 -15.577 1.00 97.51  ? 363  THR A C   1 
ATOM   595  O  O   . THR A 1 100 ? -0.727  -17.252 -15.381 1.00 94.37  ? 363  THR A O   1 
ATOM   596  C  CB  . THR A 1 100 ? -0.957  -20.299 -16.136 1.00 103.73 ? 363  THR A CB  1 
ATOM   597  O  OG1 . THR A 1 100 ? -1.085  -21.680 -15.776 1.00 95.32  ? 363  THR A OG1 1 
ATOM   598  C  CG2 . THR A 1 100 ? -0.362  -20.221 -17.527 1.00 96.70  ? 363  THR A CG2 1 
ATOM   599  N  N   . GLN A 1 101 ? 1.311   -17.866 -16.203 1.00 102.89 ? 364  GLN A N   1 
ATOM   600  C  CA  . GLN A 1 101 ? 1.764   -16.526 -16.678 1.00 102.30 ? 364  GLN A CA  1 
ATOM   601  C  C   . GLN A 1 101 ? 0.955   -16.109 -17.913 1.00 89.09  ? 364  GLN A C   1 
ATOM   602  O  O   . GLN A 1 101 ? 0.431   -16.994 -18.606 1.00 83.74  ? 364  GLN A O   1 
ATOM   603  C  CB  . GLN A 1 101 ? 3.262   -16.544 -17.003 1.00 109.20 ? 364  GLN A CB  1 
ATOM   604  C  CG  . GLN A 1 101 ? 3.848   -15.160 -17.284 1.00 120.66 ? 364  GLN A CG  1 
ATOM   605  C  CD  . GLN A 1 101 ? 5.332   -15.166 -17.575 1.00 125.34 ? 364  GLN A CD  1 
ATOM   606  O  OE1 . GLN A 1 101 ? 5.858   -16.075 -18.219 1.00 122.68 ? 364  GLN A OE1 1 
ATOM   607  N  NE2 . GLN A 1 101 ? 6.023   -14.132 -17.115 1.00 117.07 ? 364  GLN A NE2 1 
ATOM   608  N  N   . GLU A 1 102 ? 0.866   -14.804 -18.184 1.00 83.54  ? 365  GLU A N   1 
ATOM   609  C  CA  . GLU A 1 102 ? 0.331   -14.282 -19.470 1.00 85.67  ? 365  GLU A CA  1 
ATOM   610  C  C   . GLU A 1 102 ? 1.265   -14.766 -20.583 1.00 76.79  ? 365  GLU A C   1 
ATOM   611  O  O   . GLU A 1 102 ? 2.471   -14.536 -20.565 1.00 74.00  ? 365  GLU A O   1 
ATOM   612  C  CB  . GLU A 1 102 ? 0.140   -12.757 -19.415 1.00 99.78  ? 365  GLU A CB  1 
ATOM   613  C  CG  . GLU A 1 102 ? -0.274  -12.093 -20.739 1.00 111.26 ? 365  GLU A CG  1 
ATOM   614  C  CD  . GLU A 1 102 ? -1.751  -11.804 -21.030 1.00 116.85 ? 365  GLU A CD  1 
ATOM   615  O  OE1 . GLU A 1 102 ? -2.019  -10.763 -21.670 1.00 124.01 ? 365  GLU A OE1 1 
ATOM   616  O  OE2 . GLU A 1 102 ? -2.634  -12.620 -20.672 1.00 110.28 ? 365  GLU A OE2 1 
ATOM   617  N  N   . PRO A 1 103 ? 0.748   -15.508 -21.583 1.00 70.52  ? 366  PRO A N   1 
ATOM   618  C  CA  . PRO A 1 103 ? 1.549   -15.869 -22.752 1.00 65.04  ? 366  PRO A CA  1 
ATOM   619  C  C   . PRO A 1 103 ? 2.241   -14.656 -23.400 1.00 58.96  ? 366  PRO A C   1 
ATOM   620  O  O   . PRO A 1 103 ? 1.718   -13.594 -23.300 1.00 56.39  ? 366  PRO A O   1 
ATOM   621  C  CB  . PRO A 1 103 ? 0.488   -16.463 -23.703 1.00 59.52  ? 366  PRO A CB  1 
ATOM   622  C  CG  . PRO A 1 103 ? -0.556  -17.033 -22.778 1.00 63.78  ? 366  PRO A CG  1 
ATOM   623  C  CD  . PRO A 1 103 ? -0.627  -16.039 -21.642 1.00 65.62  ? 366  PRO A CD  1 
ATOM   624  N  N   . LYS A 1 104 ? 3.370   -14.866 -24.078 1.00 62.86  ? 367  LYS A N   1 
ATOM   625  C  CA  . LYS A 1 104 ? 4.013   -13.862 -24.973 1.00 63.10  ? 367  LYS A CA  1 
ATOM   626  C  C   . LYS A 1 104 ? 3.029   -13.427 -26.070 1.00 62.85  ? 367  LYS A C   1 
ATOM   627  O  O   . LYS A 1 104 ? 2.140   -14.216 -26.426 1.00 57.78  ? 367  LYS A O   1 
ATOM   628  C  CB  . LYS A 1 104 ? 5.269   -14.419 -25.657 1.00 68.20  ? 367  LYS A CB  1 
ATOM   629  C  CG  . LYS A 1 104 ? 6.260   -15.186 -24.782 1.00 72.18  ? 367  LYS A CG  1 
ATOM   630  C  CD  . LYS A 1 104 ? 6.588   -14.496 -23.494 1.00 78.47  ? 367  LYS A CD  1 
ATOM   631  C  CE  . LYS A 1 104 ? 7.524   -15.284 -22.608 1.00 80.13  ? 367  LYS A CE  1 
ATOM   632  N  NZ  . LYS A 1 104 ? 7.499   -14.732 -21.230 1.00 84.88  ? 367  LYS A NZ  1 
ATOM   633  N  N   . GLU A 1 105 ? 3.254   -12.242 -26.641 1.00 59.93  ? 368  GLU A N   1 
ATOM   634  C  CA  . GLU A 1 105 ? 2.395   -11.597 -27.666 1.00 59.17  ? 368  GLU A CA  1 
ATOM   635  C  C   . GLU A 1 105 ? 2.289   -12.502 -28.890 1.00 54.02  ? 368  GLU A C   1 
ATOM   636  O  O   . GLU A 1 105 ? 1.245   -12.464 -29.552 1.00 57.63  ? 368  GLU A O   1 
ATOM   637  C  CB  . GLU A 1 105 ? 2.973   -10.251 -28.136 1.00 67.25  ? 368  GLU A CB  1 
ATOM   638  C  CG  . GLU A 1 105 ? 2.992   -9.147  -27.086 1.00 70.14  ? 368  GLU A CG  1 
ATOM   639  C  CD  . GLU A 1 105 ? 1.823   -9.098  -26.111 1.00 76.23  ? 368  GLU A CD  1 
ATOM   640  O  OE1 . GLU A 1 105 ? 0.741   -8.592  -26.487 1.00 83.96  ? 368  GLU A OE1 1 
ATOM   641  O  OE2 . GLU A 1 105 ? 1.993   -9.574  -24.971 1.00 83.42  ? 368  GLU A OE2 1 
ATOM   642  N  N   . GLY A 1 106 ? 3.364   -13.213 -29.233 1.00 54.04  ? 369  GLY A N   1 
ATOM   643  C  CA  . GLY A 1 106 ? 3.399   -14.082 -30.431 1.00 53.08  ? 369  GLY A CA  1 
ATOM   644  C  C   . GLY A 1 106 ? 2.430   -15.248 -30.259 1.00 54.76  ? 369  GLY A C   1 
ATOM   645  O  O   . GLY A 1 106 ? 1.675   -15.545 -31.189 1.00 53.80  ? 369  GLY A O   1 
ATOM   646  N  N   . THR A 1 107 ? 2.459   -15.878 -29.079 0.50 51.64  ? 370  THR A N   1 
ATOM   647  C  CA  . THR A 1 107 ? 1.519   -16.944 -28.647 0.50 54.12  ? 370  THR A CA  1 
ATOM   648  C  C   . THR A 1 107 ? 0.077   -16.423 -28.725 0.50 55.02  ? 370  THR A C   1 
ATOM   649  O  O   . THR A 1 107 ? -0.742  -17.055 -29.428 0.50 53.55  ? 370  THR A O   1 
ATOM   650  C  CB  . THR A 1 107 ? 1.865   -17.420 -27.231 0.50 55.24  ? 370  THR A CB  1 
ATOM   651  O  OG1 . THR A 1 107 ? 3.288   -17.465 -27.128 0.50 50.27  ? 370  THR A OG1 1 
ATOM   652  C  CG2 . THR A 1 107 ? 1.272   -18.774 -26.901 0.50 55.92  ? 370  THR A CG2 1 
ATOM   653  N  N   . LYS A 1 108 ? -0.214  -15.304 -28.053 0.50 55.80  ? 371  LYS A N   1 
ATOM   654  C  CA  . LYS A 1 108 ? -1.572  -14.690 -27.997 0.50 56.12  ? 371  LYS A CA  1 
ATOM   655  C  C   . LYS A 1 108 ? -2.109  -14.453 -29.417 0.50 53.17  ? 371  LYS A C   1 
ATOM   656  O  O   . LYS A 1 108 ? -3.326  -14.618 -29.622 0.50 50.15  ? 371  LYS A O   1 
ATOM   657  C  CB  . LYS A 1 108 ? -1.544  -13.396 -27.178 0.50 58.32  ? 371  LYS A CB  1 
ATOM   658  C  CG  . LYS A 1 108 ? -1.288  -13.598 -25.690 0.50 60.38  ? 371  LYS A CG  1 
ATOM   659  C  CD  . LYS A 1 108 ? -1.578  -12.386 -24.830 0.50 62.72  ? 371  LYS A CD  1 
ATOM   660  C  CE  . LYS A 1 108 ? -0.527  -11.303 -24.956 0.50 67.18  ? 371  LYS A CE  1 
ATOM   661  N  NZ  . LYS A 1 108 ? -0.379  -10.526 -23.700 0.50 69.32  ? 371  LYS A NZ  1 
ATOM   662  N  N   . LYS A 1 109 ? -1.243  -14.086 -30.362 0.50 51.18  ? 372  LYS A N   1 
ATOM   663  C  CA  . LYS A 1 109 ? -1.638  -13.824 -31.771 0.50 52.35  ? 372  LYS A CA  1 
ATOM   664  C  C   . LYS A 1 109 ? -1.930  -15.156 -32.474 0.50 51.72  ? 372  LYS A C   1 
ATOM   665  O  O   . LYS A 1 109 ? -2.887  -15.204 -33.291 0.50 49.08  ? 372  LYS A O   1 
ATOM   666  C  CB  . LYS A 1 109 ? -0.540  -13.035 -32.490 0.50 57.10  ? 372  LYS A CB  1 
ATOM   667  C  CG  . LYS A 1 109 ? -0.881  -12.590 -33.907 0.50 62.97  ? 372  LYS A CG  1 
ATOM   668  C  CD  . LYS A 1 109 ? -2.016  -11.579 -33.978 0.50 66.93  ? 372  LYS A CD  1 
ATOM   669  C  CE  . LYS A 1 109 ? -1.695  -10.278 -33.274 0.50 68.59  ? 372  LYS A CE  1 
ATOM   670  N  NZ  . LYS A 1 109 ? -2.669  -9.214  -33.613 0.50 68.58  ? 372  LYS A NZ  1 
ATOM   671  N  N   . LEU A 1 110 ? -1.132  -16.189 -32.173 0.50 52.27  ? 373  LEU A N   1 
ATOM   672  C  CA  . LEU A 1 110 ? -1.263  -17.558 -32.745 0.50 49.83  ? 373  LEU A CA  1 
ATOM   673  C  C   . LEU A 1 110 ? -2.635  -18.118 -32.350 0.50 45.88  ? 373  LEU A C   1 
ATOM   674  O  O   . LEU A 1 110 ? -3.352  -18.618 -33.235 0.50 43.76  ? 373  LEU A O   1 
ATOM   675  C  CB  . LEU A 1 110 ? -0.126  -18.446 -32.223 0.50 49.97  ? 373  LEU A CB  1 
ATOM   676  C  CG  . LEU A 1 110 ? 1.232   -18.270 -32.908 0.50 50.23  ? 373  LEU A CG  1 
ATOM   677  C  CD1 . LEU A 1 110 ? 2.324   -19.022 -32.159 0.50 49.26  ? 373  LEU A CD1 1 
ATOM   678  C  CD2 . LEU A 1 110 ? 1.179   -18.721 -34.362 0.50 50.72  ? 373  LEU A CD2 1 
ATOM   679  N  N   . MET A 1 111 ? -2.976  -18.011 -31.067 0.50 43.29  ? 374  MET A N   1 
ATOM   680  C  CA  . MET A 1 111 ? -4.252  -18.503 -30.487 0.50 46.06  ? 374  MET A CA  1 
ATOM   681  C  C   . MET A 1 111 ? -5.427  -17.758 -31.135 0.50 47.15  ? 374  MET A C   1 
ATOM   682  O  O   . MET A 1 111 ? -6.279  -18.435 -31.769 0.50 40.46  ? 374  MET A O   1 
ATOM   683  C  CB  . MET A 1 111 ? -4.260  -18.306 -28.967 0.50 46.32  ? 374  MET A CB  1 
ATOM   684  C  CG  . MET A 1 111 ? -3.113  -19.026 -28.282 0.50 46.37  ? 374  MET A CG  1 
ATOM   685  S  SD  . MET A 1 111 ? -3.439  -19.492 -26.566 0.50 50.51  ? 374  MET A SD  1 
ATOM   686  C  CE  . MET A 1 111 ? -3.198  -17.927 -25.728 0.50 49.86  ? 374  MET A CE  1 
ATOM   687  N  N   . LYS A 1 112 ? -5.449  -16.424 -31.002 0.50 48.54  ? 375  LYS A N   1 
ATOM   688  C  CA  . LYS A 1 112 ? -6.539  -15.531 -31.485 0.50 49.69  ? 375  LYS A CA  1 
ATOM   689  C  C   . LYS A 1 112 ? -6.872  -15.889 -32.937 0.50 49.94  ? 375  LYS A C   1 
ATOM   690  O  O   . LYS A 1 112 ? -8.048  -16.129 -33.226 0.50 46.64  ? 375  LYS A O   1 
ATOM   691  C  CB  . LYS A 1 112 ? -6.124  -14.061 -31.379 0.50 54.58  ? 375  LYS A CB  1 
ATOM   692  C  CG  . LYS A 1 112 ? -7.100  -13.151 -30.645 0.50 57.72  ? 375  LYS A CG  1 
ATOM   693  C  CD  . LYS A 1 112 ? -6.900  -13.152 -29.137 0.50 59.45  ? 375  LYS A CD  1 
ATOM   694  C  CE  . LYS A 1 112 ? -8.087  -12.608 -28.366 0.50 59.87  ? 375  LYS A CE  1 
ATOM   695  N  NZ  . LYS A 1 112 ? -8.069  -13.039 -26.947 0.50 58.54  ? 375  LYS A NZ  1 
ATOM   696  N  N   . ILE A 1 113 ? -5.862  -15.942 -33.808 1.00 48.95  ? 376  ILE A N   1 
ATOM   697  C  CA  . ILE A 1 113 ? -6.059  -16.273 -35.249 1.00 49.73  ? 376  ILE A CA  1 
ATOM   698  C  C   . ILE A 1 113 ? -6.649  -17.682 -35.391 1.00 52.40  ? 376  ILE A C   1 
ATOM   699  O  O   . ILE A 1 113 ? -7.576  -17.868 -36.248 1.00 49.36  ? 376  ILE A O   1 
ATOM   700  C  CB  . ILE A 1 113 ? -4.740  -16.148 -36.033 1.00 48.51  ? 376  ILE A CB  1 
ATOM   701  C  CG1 . ILE A 1 113 ? -4.256  -14.697 -36.118 1.00 60.08  ? 376  ILE A CG1 1 
ATOM   702  C  CG2 . ILE A 1 113 ? -4.891  -16.743 -37.419 1.00 47.58  ? 376  ILE A CG2 1 
ATOM   703  C  CD1 . ILE A 1 113 ? -2.789  -14.545 -36.479 1.00 63.73  ? 376  ILE A CD1 1 
ATOM   704  N  N   . THR A 1 114 ? -6.113  -18.652 -34.637 1.00 46.44  ? 377  THR A N   1 
ATOM   705  C  CA  . THR A 1 114 ? -6.539  -20.077 -34.737 1.00 40.43  ? 377  THR A CA  1 
ATOM   706  C  C   . THR A 1 114 ? -7.984  -20.176 -34.232 1.00 38.73  ? 377  THR A C   1 
ATOM   707  O  O   . THR A 1 114 ? -8.770  -20.844 -34.907 1.00 33.95  ? 377  THR A O   1 
ATOM   708  C  CB  . THR A 1 114 ? -5.549  -21.020 -34.035 1.00 37.66  ? 377  THR A CB  1 
ATOM   709  O  OG1 . THR A 1 114 ? -4.226  -20.696 -34.456 1.00 40.86  ? 377  THR A OG1 1 
ATOM   710  C  CG2 . THR A 1 114 ? -5.799  -22.469 -34.360 1.00 37.13  ? 377  THR A CG2 1 
ATOM   711  N  N   . ALA A 1 115 ? -8.308  -19.512 -33.111 1.00 39.45  ? 378  ALA A N   1 
ATOM   712  C  CA  . ALA A 1 115 ? -9.616  -19.573 -32.433 1.00 42.28  ? 378  ALA A CA  1 
ATOM   713  C  C   . ALA A 1 115 ? -10.679 -18.970 -33.353 1.00 46.72  ? 378  ALA A C   1 
ATOM   714  O  O   . ALA A 1 115 ? -11.731 -19.626 -33.568 1.00 43.75  ? 378  ALA A O   1 
ATOM   715  C  CB  . ALA A 1 115 ? -9.597  -18.894 -31.093 1.00 41.68  ? 378  ALA A CB  1 
ATOM   716  N  N   . GLU A 1 116 ? -10.410 -17.779 -33.904 0.50 46.79  ? 379  GLU A N   1 
ATOM   717  C  CA  . GLU A 1 116 ? -11.317 -17.081 -34.858 0.50 47.94  ? 379  GLU A CA  1 
ATOM   718  C  C   . GLU A 1 116 ? -11.616 -18.028 -36.023 0.50 45.51  ? 379  GLU A C   1 
ATOM   719  O  O   . GLU A 1 116 ? -12.795 -18.206 -36.348 0.50 50.08  ? 379  GLU A O   1 
ATOM   720  C  CB  . GLU A 1 116 ? -10.710 -15.760 -35.339 0.50 50.29  ? 379  GLU A CB  1 
ATOM   721  C  CG  . GLU A 1 116 ? -11.718 -14.845 -36.015 0.50 53.02  ? 379  GLU A CG  1 
ATOM   722  C  CD  . GLU A 1 116 ? -11.313 -13.381 -36.095 0.50 53.63  ? 379  GLU A CD  1 
ATOM   723  O  OE1 . GLU A 1 116 ? -10.195 -13.058 -35.632 0.50 52.44  ? 379  GLU A OE1 1 
ATOM   724  O  OE2 . GLU A 1 116 ? -12.114 -12.570 -36.624 0.50 52.18  ? 379  GLU A OE2 1 
ATOM   725  N  N   . TRP A 1 117 ? -10.587 -18.648 -36.597 0.50 43.27  ? 380  TRP A N   1 
ATOM   726  C  CA  . TRP A 1 117 ? -10.733 -19.619 -37.712 0.50 41.86  ? 380  TRP A CA  1 
ATOM   727  C  C   . TRP A 1 117 ? -11.507 -20.860 -37.245 0.50 42.38  ? 380  TRP A C   1 
ATOM   728  O  O   . TRP A 1 117 ? -12.279 -21.409 -38.056 0.50 45.22  ? 380  TRP A O   1 
ATOM   729  C  CB  . TRP A 1 117 ? -9.358  -19.987 -38.276 0.50 39.32  ? 380  TRP A CB  1 
ATOM   730  C  CG  . TRP A 1 117 ? -9.420  -21.071 -39.301 0.50 37.19  ? 380  TRP A CG  1 
ATOM   731  C  CD1 . TRP A 1 117 ? -9.563  -20.917 -40.645 0.50 36.84  ? 380  TRP A CD1 1 
ATOM   732  C  CD2 . TRP A 1 117 ? -9.364  -22.486 -39.061 0.50 37.33  ? 380  TRP A CD2 1 
ATOM   733  N  NE1 . TRP A 1 117 ? -9.576  -22.135 -41.263 0.50 39.29  ? 380  TRP A NE1 1 
ATOM   734  C  CE2 . TRP A 1 117 ? -9.467  -23.119 -40.315 0.50 38.47  ? 380  TRP A CE2 1 
ATOM   735  C  CE3 . TRP A 1 117 ? -9.230  -23.278 -37.918 0.50 38.00  ? 380  TRP A CE3 1 
ATOM   736  C  CZ2 . TRP A 1 117 ? -9.453  -24.505 -40.453 0.50 39.20  ? 380  TRP A CZ2 1 
ATOM   737  C  CZ3 . TRP A 1 117 ? -9.202  -24.646 -38.056 0.50 37.16  ? 380  TRP A CZ3 1 
ATOM   738  C  CH2 . TRP A 1 117 ? -9.319  -25.250 -39.306 0.50 37.99  ? 380  TRP A CH2 1 
ATOM   739  N  N   . LEU A 1 118 ? -11.301 -21.310 -36.002 1.00 41.64  ? 381  LEU A N   1 
ATOM   740  C  CA  . LEU A 1 118 ? -11.892 -22.605 -35.533 1.00 39.81  ? 381  LEU A CA  1 
ATOM   741  C  C   . LEU A 1 118 ? -13.407 -22.441 -35.305 1.00 37.62  ? 381  LEU A C   1 
ATOM   742  O  O   . LEU A 1 118 ? -14.184 -23.273 -35.849 1.00 32.92  ? 381  LEU A O   1 
ATOM   743  C  CB  . LEU A 1 118 ? -11.157 -23.135 -34.297 1.00 38.46  ? 381  LEU A CB  1 
ATOM   744  C  CG  . LEU A 1 118 ? -11.508 -24.572 -33.909 1.00 41.37  ? 381  LEU A CG  1 
ATOM   745  C  CD1 . LEU A 1 118 ? -11.337 -25.553 -35.075 1.00 43.89  ? 381  LEU A CD1 1 
ATOM   746  C  CD2 . LEU A 1 118 ? -10.700 -25.018 -32.714 1.00 41.27  ? 381  LEU A CD2 1 
ATOM   747  N  N   . TRP A 1 119 ? -13.830 -21.395 -34.586 1.00 34.15  ? 382  TRP A N   1 
ATOM   748  C  CA  . TRP A 1 119 ? -15.264 -21.051 -34.410 1.00 38.79  ? 382  TRP A CA  1 
ATOM   749  C  C   . TRP A 1 119 ? -15.946 -20.905 -35.784 1.00 42.12  ? 382  TRP A C   1 
ATOM   750  O  O   . TRP A 1 119 ? -17.092 -21.431 -35.950 1.00 52.95  ? 382  TRP A O   1 
ATOM   751  C  CB  . TRP A 1 119 ? -15.380 -19.783 -33.580 1.00 37.37  ? 382  TRP A CB  1 
ATOM   752  C  CG  . TRP A 1 119 ? -15.190 -19.988 -32.114 1.00 33.67  ? 382  TRP A CG  1 
ATOM   753  C  CD1 . TRP A 1 119 ? -14.388 -19.255 -31.293 1.00 35.24  ? 382  TRP A CD1 1 
ATOM   754  C  CD2 . TRP A 1 119 ? -15.829 -20.972 -31.281 1.00 35.59  ? 382  TRP A CD2 1 
ATOM   755  N  NE1 . TRP A 1 119 ? -14.511 -19.681 -29.998 1.00 35.86  ? 382  TRP A NE1 1 
ATOM   756  C  CE2 . TRP A 1 119 ? -15.390 -20.737 -29.964 1.00 35.71  ? 382  TRP A CE2 1 
ATOM   757  C  CE3 . TRP A 1 119 ? -16.773 -21.983 -31.508 1.00 39.31  ? 382  TRP A CE3 1 
ATOM   758  C  CZ2 . TRP A 1 119 ? -15.804 -21.531 -28.898 1.00 39.54  ? 382  TRP A CZ2 1 
ATOM   759  C  CZ3 . TRP A 1 119 ? -17.201 -22.749 -30.451 1.00 34.42  ? 382  TRP A CZ3 1 
ATOM   760  C  CH2 . TRP A 1 119 ? -16.727 -22.522 -29.166 1.00 34.32  ? 382  TRP A CH2 1 
ATOM   761  N  N   . LYS A 1 120 ? -15.260 -20.306 -36.765 1.00 41.20  ? 383  LYS A N   1 
ATOM   762  C  CA  . LYS A 1 120 ? -15.768 -20.191 -38.156 1.00 45.66  ? 383  LYS A CA  1 
ATOM   763  C  C   . LYS A 1 120 ? -16.008 -21.587 -38.716 1.00 44.20  ? 383  LYS A C   1 
ATOM   764  O  O   . LYS A 1 120 ? -17.061 -21.782 -39.293 1.00 46.23  ? 383  LYS A O   1 
ATOM   765  C  CB  . LYS A 1 120 ? -14.861 -19.438 -39.135 1.00 56.37  ? 383  LYS A CB  1 
ATOM   766  C  CG  . LYS A 1 120 ? -15.190 -17.974 -39.390 1.00 72.58  ? 383  LYS A CG  1 
ATOM   767  C  CD  . LYS A 1 120 ? -14.994 -17.562 -40.849 1.00 82.69  ? 383  LYS A CD  1 
ATOM   768  C  CE  . LYS A 1 120 ? -14.911 -16.062 -41.045 1.00 97.15  ? 383  LYS A CE  1 
ATOM   769  N  NZ  . LYS A 1 120 ? -13.905 -15.444 -40.141 1.00 100.17 ? 383  LYS A NZ  1 
ATOM   770  N  N   . GLU A 1 121 ? -15.073 -22.527 -38.593 1.00 44.44  ? 384  GLU A N   1 
ATOM   771  C  CA  . GLU A 1 121 ? -15.261 -23.862 -39.222 1.00 43.70  ? 384  GLU A CA  1 
ATOM   772  C  C   . GLU A 1 121 ? -16.373 -24.620 -38.513 1.00 40.54  ? 384  GLU A C   1 
ATOM   773  O  O   . GLU A 1 121 ? -17.090 -25.384 -39.184 1.00 40.49  ? 384  GLU A O   1 
ATOM   774  C  CB  . GLU A 1 121 ? -14.017 -24.726 -39.084 1.00 47.98  ? 384  GLU A CB  1 
ATOM   775  C  CG  . GLU A 1 121 ? -12.920 -24.241 -39.968 1.00 52.62  ? 384  GLU A CG  1 
ATOM   776  C  CD  . GLU A 1 121 ? -13.183 -24.489 -41.431 1.00 52.13  ? 384  GLU A CD  1 
ATOM   777  O  OE1 . GLU A 1 121 ? -13.579 -25.626 -41.798 1.00 54.94  ? 384  GLU A OE1 1 
ATOM   778  O  OE2 . GLU A 1 121 ? -12.977 -23.541 -42.171 1.00 51.54  ? 384  GLU A OE2 1 
ATOM   779  N  N   . LEU A 1 122 ? -16.453 -24.466 -37.191 1.00 35.58  ? 385  LEU A N   1 
ATOM   780  C  CA  . LEU A 1 122 ? -17.410 -25.248 -36.394 1.00 39.67  ? 385  LEU A CA  1 
ATOM   781  C  C   . LEU A 1 122 ? -18.809 -24.738 -36.749 1.00 40.28  ? 385  LEU A C   1 
ATOM   782  O  O   . LEU A 1 122 ? -19.699 -25.564 -36.838 1.00 39.97  ? 385  LEU A O   1 
ATOM   783  C  CB  . LEU A 1 122 ? -17.085 -25.113 -34.910 1.00 35.93  ? 385  LEU A CB  1 
ATOM   784  C  CG  . LEU A 1 122 ? -15.813 -25.839 -34.469 1.00 35.51  ? 385  LEU A CG  1 
ATOM   785  C  CD1 . LEU A 1 122 ? -15.565 -25.647 -32.997 1.00 35.40  ? 385  LEU A CD1 1 
ATOM   786  C  CD2 . LEU A 1 122 ? -15.890 -27.306 -34.791 1.00 38.81  ? 385  LEU A CD2 1 
ATOM   787  N  N   . GLY A 1 123 ? -18.918 -23.441 -37.033 1.00 46.74  ? 386  GLY A N   1 
ATOM   788  C  CA  . GLY A 1 123 ? -20.181 -22.735 -37.307 1.00 47.84  ? 386  GLY A CA  1 
ATOM   789  C  C   . GLY A 1 123 ? -20.608 -22.808 -38.762 1.00 48.48  ? 386  GLY A C   1 
ATOM   790  O  O   . GLY A 1 123 ? -21.703 -22.326 -39.033 1.00 54.36  ? 386  GLY A O   1 
ATOM   791  N  N   . LYS A 1 124 ? -19.835 -23.431 -39.658 1.00 46.20  ? 387  LYS A N   1 
ATOM   792  C  CA  . LYS A 1 124 ? -20.171 -23.459 -41.109 1.00 48.21  ? 387  LYS A CA  1 
ATOM   793  C  C   . LYS A 1 124 ? -21.479 -24.214 -41.372 1.00 51.48  ? 387  LYS A C   1 
ATOM   794  O  O   . LYS A 1 124 ? -22.107 -23.884 -42.364 1.00 50.07  ? 387  LYS A O   1 
ATOM   795  C  CB  . LYS A 1 124 ? -19.088 -24.103 -41.973 1.00 50.46  ? 387  LYS A CB  1 
ATOM   796  C  CG  . LYS A 1 124 ? -17.979 -23.151 -42.429 1.00 55.73  ? 387  LYS A CG  1 
ATOM   797  C  CD  . LYS A 1 124 ? -16.969 -23.851 -43.342 1.00 59.20  ? 387  LYS A CD  1 
ATOM   798  C  CE  . LYS A 1 124 ? -15.756 -23.029 -43.715 1.00 59.15  ? 387  LYS A CE  1 
ATOM   799  N  NZ  . LYS A 1 124 ? -14.793 -23.887 -44.450 1.00 69.06  ? 387  LYS A NZ  1 
ATOM   800  N  N   . LYS A 1 125 ? -21.809 -25.242 -40.589 1.00 47.62  ? 388  LYS A N   1 
ATOM   801  C  CA  . LYS A 1 125 ? -22.971 -26.138 -40.834 1.00 50.84  ? 388  LYS A CA  1 
ATOM   802  C  C   . LYS A 1 125 ? -23.826 -26.266 -39.568 1.00 45.03  ? 388  LYS A C   1 
ATOM   803  O  O   . LYS A 1 125 ? -24.477 -27.281 -39.409 1.00 51.86  ? 388  LYS A O   1 
ATOM   804  C  CB  . LYS A 1 125 ? -22.487 -27.526 -41.238 1.00 50.47  ? 388  LYS A CB  1 
ATOM   805  C  CG  . LYS A 1 125 ? -21.732 -27.597 -42.547 1.00 56.19  ? 388  LYS A CG  1 
ATOM   806  C  CD  . LYS A 1 125 ? -21.293 -29.020 -42.867 1.00 67.50  ? 388  LYS A CD  1 
ATOM   807  C  CE  . LYS A 1 125 ? -20.080 -29.460 -42.064 1.00 77.73  ? 388  LYS A CE  1 
ATOM   808  N  NZ  . LYS A 1 125 ? -20.157 -30.895 -41.682 1.00 81.66  ? 388  LYS A NZ  1 
ATOM   809  N  N   . LYS A 1 126 ? -23.727 -25.308 -38.657 1.00 42.63  ? 389  LYS A N   1 
ATOM   810  C  CA  . LYS A 1 126 ? -24.417 -25.328 -37.356 1.00 47.22  ? 389  LYS A CA  1 
ATOM   811  C  C   . LYS A 1 126 ? -24.908 -23.915 -37.115 1.00 48.63  ? 389  LYS A C   1 
ATOM   812  O  O   . LYS A 1 126 ? -24.211 -22.994 -37.530 1.00 55.29  ? 389  LYS A O   1 
ATOM   813  C  CB  . LYS A 1 126 ? -23.513 -25.708 -36.182 1.00 45.50  ? 389  LYS A CB  1 
ATOM   814  C  CG  . LYS A 1 126 ? -22.939 -27.111 -36.235 1.00 42.07  ? 389  LYS A CG  1 
ATOM   815  C  CD  . LYS A 1 126 ? -23.966 -28.147 -35.914 1.00 47.78  ? 389  LYS A CD  1 
ATOM   816  C  CE  . LYS A 1 126 ? -23.345 -29.519 -35.872 1.00 46.98  ? 389  LYS A CE  1 
ATOM   817  N  NZ  . LYS A 1 126 ? -24.371 -30.562 -35.851 1.00 45.20  ? 389  LYS A NZ  1 
ATOM   818  N  N   . THR A 1 127 ? -26.057 -23.789 -36.451 1.00 55.14  ? 390  THR A N   1 
ATOM   819  C  CA  . THR A 1 127 ? -26.685 -22.500 -36.087 1.00 53.74  ? 390  THR A CA  1 
ATOM   820  C  C   . THR A 1 127 ? -26.681 -22.386 -34.571 1.00 41.03  ? 390  THR A C   1 
ATOM   821  O  O   . THR A 1 127 ? -27.448 -23.041 -33.882 1.00 48.82  ? 390  THR A O   1 
ATOM   822  C  CB  . THR A 1 127 ? -28.112 -22.384 -36.659 1.00 59.12  ? 390  THR A CB  1 
ATOM   823  O  OG1 . THR A 1 127 ? -28.055 -22.514 -38.082 1.00 54.49  ? 390  THR A OG1 1 
ATOM   824  C  CG2 . THR A 1 127 ? -28.764 -21.064 -36.311 1.00 57.87  ? 390  THR A CG2 1 
ATOM   825  N  N   . PRO A 1 128 ? -25.903 -21.460 -34.000 1.00 36.23  ? 391  PRO A N   1 
ATOM   826  C  CA  . PRO A 1 128 ? -26.051 -21.162 -32.580 1.00 38.15  ? 391  PRO A CA  1 
ATOM   827  C  C   . PRO A 1 128 ? -27.531 -20.840 -32.280 1.00 46.31  ? 391  PRO A C   1 
ATOM   828  O  O   . PRO A 1 128 ? -28.227 -20.233 -33.109 1.00 46.23  ? 391  PRO A O   1 
ATOM   829  C  CB  . PRO A 1 128 ? -25.192 -19.923 -32.359 1.00 34.94  ? 391  PRO A CB  1 
ATOM   830  C  CG  . PRO A 1 128 ? -24.283 -19.881 -33.553 1.00 38.52  ? 391  PRO A CG  1 
ATOM   831  C  CD  . PRO A 1 128 ? -24.989 -20.568 -34.698 1.00 35.56  ? 391  PRO A CD  1 
ATOM   832  N  N   . ARG A 1 129 ? -28.013 -21.208 -31.109 1.00 46.88  ? 392  ARG A N   1 
ATOM   833  C  CA  . ARG A 1 129 ? -29.418 -20.907 -30.755 1.00 47.36  ? 392  ARG A CA  1 
ATOM   834  C  C   . ARG A 1 129 ? -29.566 -21.073 -29.259 1.00 52.83  ? 392  ARG A C   1 
ATOM   835  O  O   . ARG A 1 129 ? -28.684 -21.737 -28.666 1.00 45.91  ? 392  ARG A O   1 
ATOM   836  C  CB  . ARG A 1 129 ? -30.384 -21.774 -31.570 1.00 48.97  ? 392  ARG A CB  1 
ATOM   837  C  CG  . ARG A 1 129 ? -30.074 -23.262 -31.607 1.00 48.34  ? 392  ARG A CG  1 
ATOM   838  C  CD  . ARG A 1 129 ? -31.041 -23.993 -30.749 1.00 42.23  ? 392  ARG A CD  1 
ATOM   839  N  NE  . ARG A 1 129 ? -30.813 -25.416 -30.595 1.00 44.91  ? 392  ARG A NE  1 
ATOM   840  C  CZ  . ARG A 1 129 ? -31.292 -26.108 -29.572 1.00 46.58  ? 392  ARG A CZ  1 
ATOM   841  N  NH1 . ARG A 1 129 ? -32.051 -25.493 -28.677 1.00 47.83  ? 392  ARG A NH1 1 
ATOM   842  N  NH2 . ARG A 1 129 ? -31.061 -27.405 -29.471 1.00 40.35  ? 392  ARG A NH2 1 
ATOM   843  N  N   . MET A 1 130 ? -30.599 -20.445 -28.692 1.00 50.39  ? 393  MET A N   1 
ATOM   844  C  CA  . MET A 1 130 ? -30.935 -20.568 -27.260 1.00 51.29  ? 393  MET A CA  1 
ATOM   845  C  C   . MET A 1 130 ? -31.532 -21.947 -27.014 1.00 49.23  ? 393  MET A C   1 
ATOM   846  O  O   . MET A 1 130 ? -32.185 -22.472 -27.902 1.00 47.61  ? 393  MET A O   1 
ATOM   847  C  CB  . MET A 1 130 ? -31.906 -19.477 -26.820 1.00 59.93  ? 393  MET A CB  1 
ATOM   848  C  CG  . MET A 1 130 ? -31.185 -18.185 -26.544 1.00 69.07  ? 393  MET A CG  1 
ATOM   849  S  SD  . MET A 1 130 ? -32.270 -16.917 -25.886 1.00 79.94  ? 393  MET A SD  1 
ATOM   850  C  CE  . MET A 1 130 ? -32.784 -16.115 -27.403 1.00 83.14  ? 393  MET A CE  1 
ATOM   851  N  N   . CYS A 1 131 ? -31.242 -22.543 -25.861 1.00 48.79  ? 394  CYS A N   1 
ATOM   852  C  CA  . CYS A 1 131 ? -31.963 -23.747 -25.367 1.00 51.09  ? 394  CYS A CA  1 
ATOM   853  C  C   . CYS A 1 131 ? -33.133 -23.301 -24.443 1.00 53.13  ? 394  CYS A C   1 
ATOM   854  O  O   . CYS A 1 131 ? -33.134 -22.144 -23.915 1.00 52.41  ? 394  CYS A O   1 
ATOM   855  C  CB  . CYS A 1 131 ? -30.985 -24.724 -24.712 1.00 52.84  ? 394  CYS A CB  1 
ATOM   856  S  SG  . CYS A 1 131 ? -29.772 -25.451 -25.853 1.00 52.24  ? 394  CYS A SG  1 
ATOM   857  N  N   . THR A 1 132 ? -34.170 -24.122 -24.305 1.00 54.61  ? 395  THR A N   1 
ATOM   858  C  CA  . THR A 1 132 ? -35.495 -23.658 -23.786 1.00 60.77  ? 395  THR A CA  1 
ATOM   859  C  C   . THR A 1 132 ? -35.784 -24.232 -22.389 1.00 58.58  ? 395  THR A C   1 
ATOM   860  O  O   . THR A 1 132 ? -35.207 -25.298 -22.029 1.00 56.73  ? 395  THR A O   1 
ATOM   861  C  CB  . THR A 1 132 ? -36.597 -23.984 -24.807 1.00 59.71  ? 395  THR A CB  1 
ATOM   862  O  OG1 . THR A 1 132 ? -36.655 -25.397 -25.009 1.00 57.12  ? 395  THR A OG1 1 
ATOM   863  C  CG2 . THR A 1 132 ? -36.376 -23.300 -26.143 1.00 59.39  ? 395  THR A CG2 1 
ATOM   864  N  N   . ARG A 1 133 ? -36.658 -23.552 -21.637 1.00 64.35  ? 396  ARG A N   1 
ATOM   865  C  CA  . ARG A 1 133 ? -37.267 -24.067 -20.372 1.00 68.74  ? 396  ARG A CA  1 
ATOM   866  C  C   . ARG A 1 133 ? -37.785 -25.493 -20.619 1.00 67.44  ? 396  ARG A C   1 
ATOM   867  O  O   . ARG A 1 133 ? -37.528 -26.381 -19.789 1.00 70.05  ? 396  ARG A O   1 
ATOM   868  C  CB  . ARG A 1 133 ? -38.379 -23.135 -19.873 1.00 77.42  ? 396  ARG A CB  1 
ATOM   869  C  CG  . ARG A 1 133 ? -38.018 -21.654 -19.923 1.00 93.37  ? 396  ARG A CG  1 
ATOM   870  C  CD  . ARG A 1 133 ? -38.677 -20.732 -18.901 1.00 102.16 ? 396  ARG A CD  1 
ATOM   871  N  NE  . ARG A 1 133 ? -37.891 -19.510 -18.701 1.00 99.16  ? 396  ARG A NE  1 
ATOM   872  C  CZ  . ARG A 1 133 ? -38.273 -18.450 -17.986 1.00 101.83 ? 396  ARG A CZ  1 
ATOM   873  N  NH1 . ARG A 1 133 ? -39.456 -18.433 -17.394 1.00 103.36 ? 396  ARG A NH1 1 
ATOM   874  N  NH2 . ARG A 1 133 ? -37.475 -17.399 -17.884 1.00 89.81  ? 396  ARG A NH2 1 
ATOM   875  N  N   . GLU A 1 134 ? -38.416 -25.718 -21.773 1.00 64.46  ? 397  GLU A N   1 
ATOM   876  C  CA  . GLU A 1 134 ? -39.042 -27.004 -22.155 1.00 65.86  ? 397  GLU A CA  1 
ATOM   877  C  C   . GLU A 1 134 ? -37.986 -28.109 -22.274 1.00 66.67  ? 397  GLU A C   1 
ATOM   878  O  O   . GLU A 1 134 ? -38.187 -29.164 -21.689 1.00 72.15  ? 397  GLU A O   1 
ATOM   879  C  CB  . GLU A 1 134 ? -39.870 -26.822 -23.426 1.00 74.94  ? 397  GLU A CB  1 
ATOM   880  C  CG  . GLU A 1 134 ? -41.118 -25.980 -23.219 1.00 81.93  ? 397  GLU A CG  1 
ATOM   881  C  CD  . GLU A 1 134 ? -40.969 -24.460 -23.197 1.00 92.35  ? 397  GLU A CD  1 
ATOM   882  O  OE1 . GLU A 1 134 ? -39.862 -23.947 -23.502 1.00 78.39  ? 397  GLU A OE1 1 
ATOM   883  O  OE2 . GLU A 1 134 ? -41.983 -23.778 -22.894 1.00 97.01  ? 397  GLU A OE2 1 
ATOM   884  N  N   . GLU A 1 135 ? -36.910 -27.898 -23.040 0.26 68.81  ? 398  GLU A N   1 
ATOM   885  C  CA  . GLU A 1 135 ? -35.889 -28.959 -23.284 0.26 67.82  ? 398  GLU A CA  1 
ATOM   886  C  C   . GLU A 1 135 ? -35.000 -29.100 -22.040 0.26 68.22  ? 398  GLU A C   1 
ATOM   887  O  O   . GLU A 1 135 ? -34.435 -30.198 -21.847 0.26 68.02  ? 398  GLU A O   1 
ATOM   888  C  CB  . GLU A 1 135 ? -35.094 -28.693 -24.567 0.26 66.64  ? 398  GLU A CB  1 
ATOM   889  C  CG  . GLU A 1 135 ? -33.890 -27.787 -24.392 0.26 64.76  ? 398  GLU A CG  1 
ATOM   890  C  CD  . GLU A 1 135 ? -33.302 -27.286 -25.701 0.26 63.82  ? 398  GLU A CD  1 
ATOM   891  O  OE1 . GLU A 1 135 ? -33.662 -26.168 -26.115 0.26 62.03  ? 398  GLU A OE1 1 
ATOM   892  O  OE2 . GLU A 1 135 ? -32.485 -28.013 -26.301 0.26 61.10  ? 398  GLU A OE2 1 
ATOM   893  N  N   . PHE A 1 136 ? -34.898 -28.040 -21.228 0.26 67.14  ? 399  PHE A N   1 
ATOM   894  C  CA  . PHE A 1 136 ? -34.183 -28.027 -19.924 0.26 67.86  ? 399  PHE A CA  1 
ATOM   895  C  C   . PHE A 1 136 ? -34.921 -28.925 -18.922 0.26 69.54  ? 399  PHE A C   1 
ATOM   896  O  O   . PHE A 1 136 ? -34.248 -29.619 -18.136 0.26 69.15  ? 399  PHE A O   1 
ATOM   897  C  CB  . PHE A 1 136 ? -34.046 -26.596 -19.395 0.26 68.16  ? 399  PHE A CB  1 
ATOM   898  C  CG  . PHE A 1 136 ? -33.438 -26.491 -18.018 0.26 68.69  ? 399  PHE A CG  1 
ATOM   899  C  CD1 . PHE A 1 136 ? -32.080 -26.696 -17.823 0.26 68.86  ? 399  PHE A CD1 1 
ATOM   900  C  CD2 . PHE A 1 136 ? -34.223 -26.186 -16.916 0.26 69.11  ? 399  PHE A CD2 1 
ATOM   901  C  CE1 . PHE A 1 136 ? -31.522 -26.601 -16.557 0.26 69.32  ? 399  PHE A CE1 1 
ATOM   902  C  CE2 . PHE A 1 136 ? -33.663 -26.091 -15.651 0.26 69.95  ? 399  PHE A CE2 1 
ATOM   903  C  CZ  . PHE A 1 136 ? -32.314 -26.298 -15.473 0.26 69.37  ? 399  PHE A CZ  1 
ATOM   904  N  N   . THR A 1 137 ? -36.259 -28.900 -18.947 0.26 71.29  ? 400  THR A N   1 
ATOM   905  C  CA  . THR A 1 137 ? -37.149 -29.714 -18.071 0.26 72.11  ? 400  THR A CA  1 
ATOM   906  C  C   . THR A 1 137 ? -37.011 -31.200 -18.428 0.26 72.61  ? 400  THR A C   1 
ATOM   907  O  O   . THR A 1 137 ? -36.863 -32.014 -17.502 0.26 71.02  ? 400  THR A O   1 
ATOM   908  C  CB  . THR A 1 137 ? -38.606 -29.249 -18.173 0.26 71.73  ? 400  THR A CB  1 
ATOM   909  O  OG1 . THR A 1 137 ? -38.668 -27.909 -17.682 0.26 72.69  ? 400  THR A OG1 1 
ATOM   910  C  CG2 . THR A 1 137 ? -39.561 -30.134 -17.404 0.26 71.67  ? 400  THR A CG2 1 
ATOM   911  N  N   . ARG A 1 138 ? -37.049 -31.532 -19.721 0.26 74.58  ? 401  ARG A N   1 
ATOM   912  C  CA  . ARG A 1 138 ? -36.907 -32.920 -20.244 0.26 76.24  ? 401  ARG A CA  1 
ATOM   913  C  C   . ARG A 1 138 ? -35.629 -33.571 -19.692 0.26 77.09  ? 401  ARG A C   1 
ATOM   914  O  O   . ARG A 1 138 ? -35.563 -34.815 -19.693 0.26 78.35  ? 401  ARG A O   1 
ATOM   915  C  CB  . ARG A 1 138 ? -36.898 -32.908 -21.776 0.26 78.51  ? 401  ARG A CB  1 
ATOM   916  C  CG  . ARG A 1 138 ? -38.276 -32.743 -22.404 0.26 79.05  ? 401  ARG A CG  1 
ATOM   917  C  CD  . ARG A 1 138 ? -38.274 -31.992 -23.726 0.26 80.44  ? 401  ARG A CD  1 
ATOM   918  N  NE  . ARG A 1 138 ? -37.062 -32.173 -24.519 0.26 81.34  ? 401  ARG A NE  1 
ATOM   919  C  CZ  . ARG A 1 138 ? -36.734 -33.273 -25.195 0.26 82.31  ? 401  ARG A CZ  1 
ATOM   920  N  NH1 . ARG A 1 138 ? -37.521 -34.338 -25.184 0.26 81.40  ? 401  ARG A NH1 1 
ATOM   921  N  NH2 . ARG A 1 138 ? -35.602 -33.305 -25.878 0.26 83.15  ? 401  ARG A NH2 1 
ATOM   922  N  N   . LYS A 1 139 ? -34.651 -32.767 -19.258 0.26 76.09  ? 402  LYS A N   1 
ATOM   923  C  CA  . LYS A 1 139 ? -33.389 -33.236 -18.621 0.26 76.84  ? 402  LYS A CA  1 
ATOM   924  C  C   . LYS A 1 139 ? -33.602 -33.463 -17.117 0.26 78.89  ? 402  LYS A C   1 
ATOM   925  O  O   . LYS A 1 139 ? -33.004 -34.423 -16.587 0.26 81.19  ? 402  LYS A O   1 
ATOM   926  C  CB  . LYS A 1 139 ? -32.253 -32.239 -18.872 0.26 75.61  ? 402  LYS A CB  1 
ATOM   927  C  CG  . LYS A 1 139 ? -31.773 -32.160 -20.315 0.26 75.10  ? 402  LYS A CG  1 
ATOM   928  C  CD  . LYS A 1 139 ? -30.510 -31.342 -20.491 0.26 75.33  ? 402  LYS A CD  1 
ATOM   929  C  CE  . LYS A 1 139 ? -29.880 -31.502 -21.859 0.26 74.42  ? 402  LYS A CE  1 
ATOM   930  N  NZ  . LYS A 1 139 ? -29.288 -32.849 -22.045 0.26 73.63  ? 402  LYS A NZ  1 
ATOM   931  N  N   . VAL A 1 140 ? -34.408 -32.624 -16.451 0.26 79.93  ? 403  VAL A N   1 
ATOM   932  C  CA  . VAL A 1 140 ? -34.671 -32.710 -14.979 0.26 81.63  ? 403  VAL A CA  1 
ATOM   933  C  C   . VAL A 1 140 ? -35.607 -33.899 -14.712 0.26 79.91  ? 403  VAL A C   1 
ATOM   934  O  O   . VAL A 1 140 ? -35.479 -34.513 -13.632 0.26 79.53  ? 403  VAL A O   1 
ATOM   935  C  CB  . VAL A 1 140 ? -35.235 -31.402 -14.380 0.26 83.60  ? 403  VAL A CB  1 
ATOM   936  C  CG1 . VAL A 1 140 ? -34.654 -30.156 -15.035 0.26 84.80  ? 403  VAL A CG1 1 
ATOM   937  C  CG2 . VAL A 1 140 ? -36.758 -31.351 -14.398 0.26 83.96  ? 403  VAL A CG2 1 
ATOM   938  N  N   . ARG A 1 141 ? -36.508 -34.201 -15.654 0.26 77.46  ? 404  ARG A N   1 
ATOM   939  C  CA  . ARG A 1 141 ? -37.468 -35.336 -15.576 0.26 77.13  ? 404  ARG A CA  1 
ATOM   940  C  C   . ARG A 1 141 ? -36.803 -36.631 -16.060 0.26 76.87  ? 404  ARG A C   1 
ATOM   941  O  O   . ARG A 1 141 ? -37.475 -37.678 -16.007 0.26 80.08  ? 404  ARG A O   1 
ATOM   942  C  CB  . ARG A 1 141 ? -38.720 -35.045 -16.408 0.26 76.37  ? 404  ARG A CB  1 
ATOM   943  C  CG  . ARG A 1 141 ? -39.466 -33.785 -15.995 0.26 78.10  ? 404  ARG A CG  1 
ATOM   944  C  CD  . ARG A 1 141 ? -40.874 -33.742 -16.560 0.26 79.67  ? 404  ARG A CD  1 
ATOM   945  N  NE  . ARG A 1 141 ? -41.525 -32.455 -16.348 0.26 79.93  ? 404  ARG A NE  1 
ATOM   946  C  CZ  . ARG A 1 141 ? -42.037 -32.027 -15.195 0.26 81.30  ? 404  ARG A CZ  1 
ATOM   947  N  NH1 . ARG A 1 141 ? -41.982 -32.779 -14.107 0.26 83.30  ? 404  ARG A NH1 1 
ATOM   948  N  NH2 . ARG A 1 141 ? -42.603 -30.834 -15.134 0.26 82.44  ? 404  ARG A NH2 1 
ATOM   949  N  N   . SER A 1 142 ? -35.547 -36.565 -16.519 0.26 77.58  ? 405  SER A N   1 
ATOM   950  C  CA  . SER A 1 142 ? -34.741 -37.725 -16.988 0.26 79.82  ? 405  SER A CA  1 
ATOM   951  C  C   . SER A 1 142 ? -33.577 -38.006 -16.027 0.26 80.31  ? 405  SER A C   1 
ATOM   952  O  O   . SER A 1 142 ? -32.747 -38.879 -16.360 0.26 82.21  ? 405  SER A O   1 
ATOM   953  C  CB  . SER A 1 142 ? -34.236 -37.492 -18.389 0.26 81.08  ? 405  SER A CB  1 
ATOM   954  O  OG  . SER A 1 142 ? -33.250 -36.470 -18.405 0.26 80.17  ? 405  SER A OG  1 
ATOM   955  N  N   . ASN A 1 143 ? -33.521 -37.303 -14.888 0.26 79.62  ? 406  ASN A N   1 
ATOM   956  C  CA  . ASN A 1 143 ? -32.434 -37.391 -13.872 0.26 78.89  ? 406  ASN A CA  1 
ATOM   957  C  C   . ASN A 1 143 ? -31.069 -37.360 -14.568 0.26 76.95  ? 406  ASN A C   1 
ATOM   958  O  O   . ASN A 1 143 ? -30.394 -38.409 -14.603 0.26 78.54  ? 406  ASN A O   1 
ATOM   959  C  CB  . ASN A 1 143 ? -32.560 -38.637 -12.989 0.26 79.93  ? 406  ASN A CB  1 
ATOM   960  C  CG  . ASN A 1 143 ? -33.652 -38.530 -11.946 0.26 81.63  ? 406  ASN A CG  1 
ATOM   961  O  OD1 . ASN A 1 143 ? -34.460 -39.443 -11.797 0.26 83.54  ? 406  ASN A OD1 1 
ATOM   962  N  ND2 . ASN A 1 143 ? -33.689 -37.424 -11.220 0.26 82.13  ? 406  ASN A ND2 1 
ATOM   963  N  N   . ALA A 1 144 ? -30.691 -36.199 -15.109 0.26 73.75  ? 407  ALA A N   1 
ATOM   964  C  CA  . ALA A 1 144 ? -29.338 -35.900 -15.634 0.26 69.83  ? 407  ALA A CA  1 
ATOM   965  C  C   . ALA A 1 144 ? -28.625 -34.957 -14.657 0.26 66.58  ? 407  ALA A C   1 
ATOM   966  O  O   . ALA A 1 144 ? -29.321 -34.268 -13.884 0.26 62.96  ? 407  ALA A O   1 
ATOM   967  C  CB  . ALA A 1 144 ? -29.438 -35.302 -17.016 0.26 69.75  ? 407  ALA A CB  1 
ATOM   968  N  N   . ALA A 1 145 ? -27.289 -34.944 -14.685 0.26 65.74  ? 408  ALA A N   1 
ATOM   969  C  CA  . ALA A 1 145 ? -26.434 -34.027 -13.895 0.26 64.49  ? 408  ALA A CA  1 
ATOM   970  C  C   . ALA A 1 145 ? -26.653 -32.593 -14.394 0.26 64.33  ? 408  ALA A C   1 
ATOM   971  O  O   . ALA A 1 145 ? -26.269 -32.301 -15.545 0.26 65.41  ? 408  ALA A O   1 
ATOM   972  C  CB  . ALA A 1 145 ? -24.987 -34.443 -13.999 0.26 63.85  ? 408  ALA A CB  1 
ATOM   973  N  N   . LEU A 1 146 ? -27.280 -31.750 -13.567 0.26 63.12  ? 409  LEU A N   1 
ATOM   974  C  CA  . LEU A 1 146 ? -27.591 -30.328 -13.876 0.26 61.35  ? 409  LEU A CA  1 
ATOM   975  C  C   . LEU A 1 146 ? -26.695 -29.393 -13.057 0.26 59.28  ? 409  LEU A C   1 
ATOM   976  O  O   . LEU A 1 146 ? -26.611 -28.207 -13.424 0.26 57.99  ? 409  LEU A O   1 
ATOM   977  C  CB  . LEU A 1 146 ? -29.069 -30.069 -13.568 0.26 62.92  ? 409  LEU A CB  1 
ATOM   978  C  CG  . LEU A 1 146 ? -30.061 -30.917 -14.362 0.26 64.21  ? 409  LEU A CG  1 
ATOM   979  C  CD1 . LEU A 1 146 ? -31.476 -30.729 -13.839 0.26 63.92  ? 409  LEU A CD1 1 
ATOM   980  C  CD2 . LEU A 1 146 ? -29.989 -30.595 -15.848 0.26 64.80  ? 409  LEU A CD2 1 
ATOM   981  N  N   . GLY A 1 147 ? -26.045 -29.908 -12.008 0.26 58.55  ? 410  GLY A N   1 
ATOM   982  C  CA  . GLY A 1 147 ? -25.277 -29.110 -11.032 0.26 58.52  ? 410  GLY A CA  1 
ATOM   983  C  C   . GLY A 1 147 ? -26.198 -28.274 -10.157 0.26 57.10  ? 410  GLY A C   1 
ATOM   984  O  O   . GLY A 1 147 ? -25.912 -27.075 -9.971  0.26 55.72  ? 410  GLY A O   1 
ATOM   985  N  N   . ALA A 1 148 ? -27.269 -28.886 -9.644  0.26 57.46  ? 411  ALA A N   1 
ATOM   986  C  CA  . ALA A 1 148 ? -28.276 -28.261 -8.754  0.26 57.29  ? 411  ALA A CA  1 
ATOM   987  C  C   . ALA A 1 148 ? -28.697 -29.264 -7.672  0.26 56.28  ? 411  ALA A C   1 
ATOM   988  O  O   . ALA A 1 148 ? -28.359 -29.014 -6.496  0.26 55.08  ? 411  ALA A O   1 
ATOM   989  C  CB  . ALA A 1 148 ? -29.459 -27.794 -9.568  0.26 56.14  ? 411  ALA A CB  1 
ATOM   990  N  N   . TRP A 1 156 ? -37.192 -25.776 -2.514  0.26 67.74  ? 419  TRP A N   1 
ATOM   991  C  CA  . TRP A 1 156 ? -37.528 -27.051 -3.205  0.26 66.44  ? 419  TRP A CA  1 
ATOM   992  C  C   . TRP A 1 156 ? -36.507 -28.128 -2.820  0.26 69.39  ? 419  TRP A C   1 
ATOM   993  O  O   . TRP A 1 156 ? -35.320 -27.781 -2.643  0.26 71.59  ? 419  TRP A O   1 
ATOM   994  C  CB  . TRP A 1 156 ? -37.581 -26.844 -4.725  0.26 64.58  ? 419  TRP A CB  1 
ATOM   995  C  CG  . TRP A 1 156 ? -38.298 -25.597 -5.140  0.26 61.89  ? 419  TRP A CG  1 
ATOM   996  C  CD1 . TRP A 1 156 ? -39.643 -25.438 -5.304  0.26 61.85  ? 419  TRP A CD1 1 
ATOM   997  C  CD2 . TRP A 1 156 ? -37.705 -24.319 -5.436  0.26 60.07  ? 419  TRP A CD2 1 
ATOM   998  N  NE1 . TRP A 1 156 ? -39.928 -24.154 -5.684  0.26 60.78  ? 419  TRP A NE1 1 
ATOM   999  C  CE2 . TRP A 1 156 ? -38.760 -23.444 -5.774  0.26 59.39  ? 419  TRP A CE2 1 
ATOM   1000 C  CE3 . TRP A 1 156 ? -36.392 -23.830 -5.454  0.26 60.27  ? 419  TRP A CE3 1 
ATOM   1001 C  CZ2 . TRP A 1 156 ? -38.538 -22.110 -6.117  0.26 59.67  ? 419  TRP A CZ2 1 
ATOM   1002 C  CZ3 . TRP A 1 156 ? -36.174 -22.513 -5.797  0.26 59.10  ? 419  TRP A CZ3 1 
ATOM   1003 C  CH2 . TRP A 1 156 ? -37.235 -21.666 -6.124  0.26 60.12  ? 419  TRP A CH2 1 
ATOM   1004 N  N   . LYS A 1 157 ? -36.960 -29.381 -2.706  0.26 71.85  ? 420  LYS A N   1 
ATOM   1005 C  CA  . LYS A 1 157 ? -36.143 -30.554 -2.290  0.26 73.91  ? 420  LYS A CA  1 
ATOM   1006 C  C   . LYS A 1 157 ? -35.081 -30.842 -3.361  0.26 74.40  ? 420  LYS A C   1 
ATOM   1007 O  O   . LYS A 1 157 ? -33.880 -30.667 -3.066  0.26 73.16  ? 420  LYS A O   1 
ATOM   1008 C  CB  . LYS A 1 157 ? -37.052 -31.767 -2.061  0.26 75.84  ? 420  LYS A CB  1 
ATOM   1009 C  CG  . LYS A 1 157 ? -36.363 -33.028 -1.551  0.26 75.31  ? 420  LYS A CG  1 
ATOM   1010 C  CD  . LYS A 1 157 ? -37.051 -34.308 -1.983  0.26 75.37  ? 420  LYS A CD  1 
ATOM   1011 C  CE  . LYS A 1 157 ? -38.497 -34.399 -1.539  0.26 74.90  ? 420  LYS A CE  1 
ATOM   1012 N  NZ  . LYS A 1 157 ? -39.198 -35.522 -2.206  0.26 75.68  ? 420  LYS A NZ  1 
ATOM   1013 N  N   . SER A 1 158 ? -35.521 -31.261 -4.552  0.26 75.71  ? 421  SER A N   1 
ATOM   1014 C  CA  . SER A 1 158 ? -34.673 -31.615 -5.721  0.26 75.91  ? 421  SER A CA  1 
ATOM   1015 C  C   . SER A 1 158 ? -34.957 -30.649 -6.878  0.26 78.79  ? 421  SER A C   1 
ATOM   1016 O  O   . SER A 1 158 ? -35.848 -29.783 -6.728  0.26 75.92  ? 421  SER A O   1 
ATOM   1017 C  CB  . SER A 1 158 ? -34.898 -33.052 -6.128  0.26 74.78  ? 421  SER A CB  1 
ATOM   1018 O  OG  . SER A 1 158 ? -36.284 -33.364 -6.150  0.26 70.95  ? 421  SER A OG  1 
ATOM   1019 N  N   . ALA A 1 159 ? -34.219 -30.794 -7.984  0.26 81.06  ? 422  ALA A N   1 
ATOM   1020 C  CA  . ALA A 1 159 ? -34.397 -30.027 -9.241  0.26 82.54  ? 422  ALA A CA  1 
ATOM   1021 C  C   . ALA A 1 159 ? -35.757 -30.361 -9.871  0.26 82.23  ? 422  ALA A C   1 
ATOM   1022 O  O   . ALA A 1 159 ? -36.358 -29.462 -10.489 0.26 79.19  ? 422  ALA A O   1 
ATOM   1023 C  CB  . ALA A 1 159 ? -33.261 -30.325 -10.189 0.26 82.43  ? 422  ALA A CB  1 
ATOM   1024 N  N   . ARG A 1 160 ? -36.224 -31.604 -9.696  0.26 84.22  ? 423  ARG A N   1 
ATOM   1025 C  CA  . ARG A 1 160 ? -37.496 -32.133 -10.264 0.26 85.01  ? 423  ARG A CA  1 
ATOM   1026 C  C   . ARG A 1 160 ? -38.696 -31.344 -9.711  0.26 86.73  ? 423  ARG A C   1 
ATOM   1027 O  O   . ARG A 1 160 ? -39.719 -31.272 -10.420 0.26 86.07  ? 423  ARG A O   1 
ATOM   1028 C  CB  . ARG A 1 160 ? -37.620 -33.631 -9.960  0.26 85.03  ? 423  ARG A CB  1 
ATOM   1029 C  CG  . ARG A 1 160 ? -38.456 -34.412 -10.966 0.26 86.21  ? 423  ARG A CG  1 
ATOM   1030 C  CD  . ARG A 1 160 ? -38.712 -35.845 -10.530 0.26 87.43  ? 423  ARG A CD  1 
ATOM   1031 N  NE  . ARG A 1 160 ? -37.716 -36.801 -11.011 0.26 88.06  ? 423  ARG A NE  1 
ATOM   1032 C  CZ  . ARG A 1 160 ? -37.910 -37.714 -11.966 0.26 88.16  ? 423  ARG A CZ  1 
ATOM   1033 N  NH1 . ARG A 1 160 ? -36.923 -38.524 -12.308 0.26 86.48  ? 423  ARG A NH1 1 
ATOM   1034 N  NH2 . ARG A 1 160 ? -39.077 -37.824 -12.581 0.26 88.97  ? 423  ARG A NH2 1 
ATOM   1035 N  N   . GLU A 1 161 ? -38.579 -30.779 -8.501  0.26 90.57  ? 424  GLU A N   1 
ATOM   1036 C  CA  . GLU A 1 161 ? -39.658 -30.015 -7.809  0.26 92.32  ? 424  GLU A CA  1 
ATOM   1037 C  C   . GLU A 1 161 ? -39.729 -28.578 -8.342  0.26 92.85  ? 424  GLU A C   1 
ATOM   1038 O  O   . GLU A 1 161 ? -40.834 -28.147 -8.726  0.26 91.73  ? 424  GLU A O   1 
ATOM   1039 C  CB  . GLU A 1 161 ? -39.426 -29.969 -6.295  0.26 94.57  ? 424  GLU A CB  1 
ATOM   1040 C  CG  . GLU A 1 161 ? -40.030 -31.139 -5.538  0.26 96.16  ? 424  GLU A CG  1 
ATOM   1041 C  CD  . GLU A 1 161 ? -40.284 -30.869 -4.064  0.26 95.76  ? 424  GLU A CD  1 
ATOM   1042 O  OE1 . GLU A 1 161 ? -39.471 -30.154 -3.443  0.26 94.92  ? 424  GLU A OE1 1 
ATOM   1043 O  OE2 . GLU A 1 161 ? -41.302 -31.366 -3.542  0.26 95.70  ? 424  GLU A OE2 1 
ATOM   1044 N  N   . ALA A 1 162 ? -38.596 -27.867 -8.335  0.26 91.79  ? 425  ALA A N   1 
ATOM   1045 C  CA  . ALA A 1 162 ? -38.483 -26.413 -8.605  0.26 92.26  ? 425  ALA A CA  1 
ATOM   1046 C  C   . ALA A 1 162 ? -39.002 -26.068 -10.008 0.26 92.99  ? 425  ALA A C   1 
ATOM   1047 O  O   . ALA A 1 162 ? -39.564 -24.965 -10.171 0.26 89.55  ? 425  ALA A O   1 
ATOM   1048 C  CB  . ALA A 1 162 ? -37.049 -25.974 -8.433  0.26 92.18  ? 425  ALA A CB  1 
ATOM   1049 N  N   . VAL A 1 163 ? -38.811 -26.970 -10.977 0.26 95.76  ? 426  VAL A N   1 
ATOM   1050 C  CA  . VAL A 1 163 ? -39.179 -26.778 -12.414 0.26 99.72  ? 426  VAL A CA  1 
ATOM   1051 C  C   . VAL A 1 163 ? -40.707 -26.691 -12.549 0.26 103.65 ? 426  VAL A C   1 
ATOM   1052 O  O   . VAL A 1 163 ? -41.174 -25.947 -13.432 0.26 102.42 ? 426  VAL A O   1 
ATOM   1053 C  CB  . VAL A 1 163 ? -38.584 -27.898 -13.292 0.26 99.76  ? 426  VAL A CB  1 
ATOM   1054 C  CG1 . VAL A 1 163 ? -39.287 -28.021 -14.635 0.26 100.01 ? 426  VAL A CG1 1 
ATOM   1055 C  CG2 . VAL A 1 163 ? -37.087 -27.710 -13.488 0.26 99.57  ? 426  VAL A CG2 1 
ATOM   1056 N  N   . GLU A 1 164 ? -41.451 -27.421 -11.712 0.26 109.74 ? 427  GLU A N   1 
ATOM   1057 C  CA  . GLU A 1 164 ? -42.940 -27.449 -11.718 0.26 112.45 ? 427  GLU A CA  1 
ATOM   1058 C  C   . GLU A 1 164 ? -43.491 -26.120 -11.176 0.26 112.68 ? 427  GLU A C   1 
ATOM   1059 O  O   . GLU A 1 164 ? -44.597 -25.729 -11.599 0.26 113.93 ? 427  GLU A O   1 
ATOM   1060 C  CB  . GLU A 1 164 ? -43.449 -28.645 -10.910 0.26 115.14 ? 427  GLU A CB  1 
ATOM   1061 C  CG  . GLU A 1 164 ? -43.142 -29.984 -11.560 0.26 117.30 ? 427  GLU A CG  1 
ATOM   1062 C  CD  . GLU A 1 164 ? -43.179 -31.189 -10.632 0.26 120.79 ? 427  GLU A CD  1 
ATOM   1063 O  OE1 . GLU A 1 164 ? -43.856 -31.115 -9.586  0.26 121.57 ? 427  GLU A OE1 1 
ATOM   1064 O  OE2 . GLU A 1 164 ? -42.528 -32.202 -10.960 0.26 121.36 ? 427  GLU A OE2 1 
ATOM   1065 N  N   . ASP A 1 165 ? -42.746 -25.455 -10.286 0.26 111.57 ? 428  ASP A N   1 
ATOM   1066 C  CA  . ASP A 1 165 ? -43.134 -24.172 -9.636  0.26 109.75 ? 428  ASP A CA  1 
ATOM   1067 C  C   . ASP A 1 165 ? -42.828 -23.009 -10.588 0.26 108.67 ? 428  ASP A C   1 
ATOM   1068 O  O   . ASP A 1 165 ? -41.717 -22.988 -11.151 0.26 113.82 ? 428  ASP A O   1 
ATOM   1069 C  CB  . ASP A 1 165 ? -42.410 -24.005 -8.296  0.26 110.42 ? 428  ASP A CB  1 
ATOM   1070 C  CG  . ASP A 1 165 ? -42.959 -22.891 -7.421  0.26 110.97 ? 428  ASP A CG  1 
ATOM   1071 O  OD1 . ASP A 1 165 ? -43.084 -21.759 -7.923  0.26 108.87 ? 428  ASP A OD1 1 
ATOM   1072 O  OD2 . ASP A 1 165 ? -43.255 -23.165 -6.241  0.26 114.17 ? 428  ASP A OD2 1 
ATOM   1073 N  N   . SER A 1 166 ? -43.775 -22.076 -10.743 0.26 105.61 ? 429  SER A N   1 
ATOM   1074 C  CA  . SER A 1 166 ? -43.657 -20.860 -11.595 0.26 103.99 ? 429  SER A CA  1 
ATOM   1075 C  C   . SER A 1 166 ? -43.046 -19.700 -10.796 0.26 102.71 ? 429  SER A C   1 
ATOM   1076 O  O   . SER A 1 166 ? -42.625 -18.713 -11.431 0.26 104.10 ? 429  SER A O   1 
ATOM   1077 C  CB  . SER A 1 166 ? -44.989 -20.473 -12.194 0.26 104.15 ? 429  SER A CB  1 
ATOM   1078 O  OG  . SER A 1 166 ? -45.284 -21.272 -13.331 0.26 103.42 ? 429  SER A OG  1 
ATOM   1079 N  N   . GLY A 1 167 ? -43.015 -19.805 -9.462  0.26 99.51  ? 430  GLY A N   1 
ATOM   1080 C  CA  . GLY A 1 167 ? -42.313 -18.862 -8.569  0.26 96.46  ? 430  GLY A CA  1 
ATOM   1081 C  C   . GLY A 1 167 ? -40.809 -18.920 -8.778  0.26 94.33  ? 430  GLY A C   1 
ATOM   1082 O  O   . GLY A 1 167 ? -40.156 -17.867 -8.659  0.26 91.78  ? 430  GLY A O   1 
ATOM   1083 N  N   . PHE A 1 168 ? -40.285 -20.114 -9.075  0.26 92.59  ? 431  PHE A N   1 
ATOM   1084 C  CA  . PHE A 1 168 ? -38.865 -20.373 -9.435  0.26 91.96  ? 431  PHE A CA  1 
ATOM   1085 C  C   . PHE A 1 168 ? -38.480 -19.532 -10.658 0.26 88.61  ? 431  PHE A C   1 
ATOM   1086 O  O   . PHE A 1 168 ? -37.464 -18.816 -10.598 0.26 88.73  ? 431  PHE A O   1 
ATOM   1087 C  CB  . PHE A 1 168 ? -38.641 -21.862 -9.715  0.26 94.77  ? 431  PHE A CB  1 
ATOM   1088 C  CG  . PHE A 1 168 ? -37.375 -22.171 -10.473 0.26 95.55  ? 431  PHE A CG  1 
ATOM   1089 C  CD1 . PHE A 1 168 ? -36.135 -21.999 -9.878  0.26 95.54  ? 431  PHE A CD1 1 
ATOM   1090 C  CD2 . PHE A 1 168 ? -37.422 -22.625 -11.782 0.26 96.62  ? 431  PHE A CD2 1 
ATOM   1091 C  CE1 . PHE A 1 168 ? -34.970 -22.275 -10.576 0.26 96.16  ? 431  PHE A CE1 1 
ATOM   1092 C  CE2 . PHE A 1 168 ? -36.256 -22.905 -12.478 0.26 96.97  ? 431  PHE A CE2 1 
ATOM   1093 C  CZ  . PHE A 1 168 ? -35.032 -22.729 -11.873 0.26 97.00  ? 431  PHE A CZ  1 
ATOM   1094 N  N   . TRP A 1 169 ? -39.276 -19.624 -11.728 0.26 85.42  ? 432  TRP A N   1 
ATOM   1095 C  CA  . TRP A 1 169 ? -39.018 -18.971 -13.041 0.26 85.06  ? 432  TRP A CA  1 
ATOM   1096 C  C   . TRP A 1 169 ? -39.124 -17.444 -12.916 0.26 86.98  ? 432  TRP A C   1 
ATOM   1097 O  O   . TRP A 1 169 ? -38.432 -16.746 -13.686 0.26 85.52  ? 432  TRP A O   1 
ATOM   1098 C  CB  . TRP A 1 169 ? -39.963 -19.521 -14.117 0.26 82.41  ? 432  TRP A CB  1 
ATOM   1099 C  CG  . TRP A 1 169 ? -39.727 -20.963 -14.444 0.26 82.09  ? 432  TRP A CG  1 
ATOM   1100 C  CD1 . TRP A 1 169 ? -40.566 -22.009 -14.194 0.26 83.00  ? 432  TRP A CD1 1 
ATOM   1101 C  CD2 . TRP A 1 169 ? -38.561 -21.529 -15.071 0.26 82.79  ? 432  TRP A CD2 1 
ATOM   1102 N  NE1 . TRP A 1 169 ? -40.009 -23.182 -14.626 0.26 84.00  ? 432  TRP A NE1 1 
ATOM   1103 C  CE2 . TRP A 1 169 ? -38.780 -22.921 -15.169 0.26 82.87  ? 432  TRP A CE2 1 
ATOM   1104 C  CE3 . TRP A 1 169 ? -37.361 -21.002 -15.561 0.26 83.33  ? 432  TRP A CE3 1 
ATOM   1105 C  CZ2 . TRP A 1 169 ? -37.844 -23.785 -15.736 0.26 83.48  ? 432  TRP A CZ2 1 
ATOM   1106 C  CZ3 . TRP A 1 169 ? -36.437 -21.858 -16.121 0.26 84.06  ? 432  TRP A CZ3 1 
ATOM   1107 C  CH2 . TRP A 1 169 ? -36.677 -23.230 -16.207 0.26 83.55  ? 432  TRP A CH2 1 
ATOM   1108 N  N   . GLU A 1 170 ? -39.955 -16.943 -11.993 0.26 88.98  ? 433  GLU A N   1 
ATOM   1109 C  CA  . GLU A 1 170 ? -40.084 -15.488 -11.694 0.26 88.24  ? 433  GLU A CA  1 
ATOM   1110 C  C   . GLU A 1 170 ? -38.745 -14.968 -11.153 0.26 85.00  ? 433  GLU A C   1 
ATOM   1111 O  O   . GLU A 1 170 ? -38.435 -13.787 -11.400 0.26 83.40  ? 433  GLU A O   1 
ATOM   1112 C  CB  . GLU A 1 170 ? -41.226 -15.219 -10.709 0.26 89.74  ? 433  GLU A CB  1 
ATOM   1113 C  CG  . GLU A 1 170 ? -42.607 -15.265 -11.343 0.26 92.36  ? 433  GLU A CG  1 
ATOM   1114 C  CD  . GLU A 1 170 ? -43.760 -15.022 -10.381 0.26 93.62  ? 433  GLU A CD  1 
ATOM   1115 O  OE1 . GLU A 1 170 ? -43.671 -14.067 -9.582  0.26 90.84  ? 433  GLU A OE1 1 
ATOM   1116 O  OE2 . GLU A 1 170 ? -44.744 -15.791 -10.428 0.26 94.54  ? 433  GLU A OE2 1 
ATOM   1117 N  N   . LEU A 1 171 ? -37.988 -15.819 -10.449 0.26 83.25  ? 434  LEU A N   1 
ATOM   1118 C  CA  . LEU A 1 171 ? -36.625 -15.512 -9.933  0.26 83.42  ? 434  LEU A CA  1 
ATOM   1119 C  C   . LEU A 1 171 ? -35.617 -15.596 -11.086 0.26 81.85  ? 434  LEU A C   1 
ATOM   1120 O  O   . LEU A 1 171 ? -34.713 -14.741 -11.137 0.26 79.93  ? 434  LEU A O   1 
ATOM   1121 C  CB  . LEU A 1 171 ? -36.262 -16.492 -8.811  0.26 83.58  ? 434  LEU A CB  1 
ATOM   1122 C  CG  . LEU A 1 171 ? -37.168 -16.465 -7.580  0.26 83.67  ? 434  LEU A CG  1 
ATOM   1123 C  CD1 . LEU A 1 171 ? -36.939 -17.692 -6.710  0.26 83.17  ? 434  LEU A CD1 1 
ATOM   1124 C  CD2 . LEU A 1 171 ? -36.959 -15.192 -6.773  0.26 82.79  ? 434  LEU A CD2 1 
ATOM   1125 N  N   . VAL A 1 172 ? -35.767 -16.596 -11.965 0.26 80.82  ? 435  VAL A N   1 
ATOM   1126 C  CA  . VAL A 1 172 ? -34.920 -16.802 -13.181 0.26 77.28  ? 435  VAL A CA  1 
ATOM   1127 C  C   . VAL A 1 172 ? -34.992 -15.544 -14.055 0.26 76.30  ? 435  VAL A C   1 
ATOM   1128 O  O   . VAL A 1 172 ? -33.930 -15.100 -14.533 0.26 72.84  ? 435  VAL A O   1 
ATOM   1129 C  CB  . VAL A 1 172 ? -35.348 -18.055 -13.971 0.26 76.61  ? 435  VAL A CB  1 
ATOM   1130 C  CG1 . VAL A 1 172 ? -34.680 -18.120 -15.337 0.26 76.80  ? 435  VAL A CG1 1 
ATOM   1131 C  CG2 . VAL A 1 172 ? -35.086 -19.332 -13.187 0.26 77.68  ? 435  VAL A CG2 1 
ATOM   1132 N  N   . ASP A 1 173 ? -36.201 -15.003 -14.250 1.00 73.59  ? 436  ASP A N   1 
ATOM   1133 C  CA  . ASP A 1 173 ? -36.430 -13.777 -15.064 1.00 77.07  ? 436  ASP A CA  1 
ATOM   1134 C  C   . ASP A 1 173 ? -35.726 -12.591 -14.394 1.00 75.13  ? 436  ASP A C   1 
ATOM   1135 O  O   . ASP A 1 173 ? -35.165 -11.724 -15.115 1.00 67.52  ? 436  ASP A O   1 
ATOM   1136 C  CB  . ASP A 1 173 ? -37.921 -13.478 -15.262 1.00 87.93  ? 436  ASP A CB  1 
ATOM   1137 C  CG  . ASP A 1 173 ? -38.717 -14.584 -15.942 1.00 96.26  ? 436  ASP A CG  1 
ATOM   1138 O  OD1 . ASP A 1 173 ? -38.173 -15.230 -16.879 1.00 96.11  ? 436  ASP A OD1 1 
ATOM   1139 O  OD2 . ASP A 1 173 ? -39.877 -14.801 -15.519 1.00 96.21  ? 436  ASP A OD2 1 
ATOM   1140 N  N   . LYS A 1 174 ? -35.752 -12.541 -13.062 1.00 73.80  ? 437  LYS A N   1 
ATOM   1141 C  CA  . LYS A 1 174 ? -35.090 -11.444 -12.320 1.00 73.49  ? 437  LYS A CA  1 
ATOM   1142 C  C   . LYS A 1 174 ? -33.636 -11.466 -12.796 1.00 75.75  ? 437  LYS A C   1 
ATOM   1143 O  O   . LYS A 1 174 ? -33.208 -10.468 -13.423 1.00 75.75  ? 437  LYS A O   1 
ATOM   1144 C  CB  . LYS A 1 174 ? -35.267 -11.606 -10.806 1.00 74.34  ? 437  LYS A CB  1 
ATOM   1145 C  CG  . LYS A 1 174 ? -34.942 -10.372 -9.977  1.00 81.52  ? 437  LYS A CG  1 
ATOM   1146 C  CD  . LYS A 1 174 ? -34.891 -10.635 -8.481  1.00 83.94  ? 437  LYS A CD  1 
ATOM   1147 C  CE  . LYS A 1 174 ? -34.128 -9.566  -7.728  1.00 85.65  ? 437  LYS A CE  1 
ATOM   1148 N  NZ  . LYS A 1 174 ? -34.522 -9.535  -6.302  1.00 93.87  ? 437  LYS A NZ  1 
ATOM   1149 N  N   . GLU A 1 175 ? -32.965 -12.615 -12.620 1.00 69.47  ? 438  GLU A N   1 
ATOM   1150 C  CA  . GLU A 1 175 ? -31.533 -12.821 -12.973 1.00 69.78  ? 438  GLU A CA  1 
ATOM   1151 C  C   . GLU A 1 175 ? -31.316 -12.590 -14.471 1.00 63.43  ? 438  GLU A C   1 
ATOM   1152 O  O   . GLU A 1 175 ? -30.399 -11.792 -14.825 1.00 54.07  ? 438  GLU A O   1 
ATOM   1153 C  CB  . GLU A 1 175 ? -31.066 -14.222 -12.609 1.00 72.88  ? 438  GLU A CB  1 
ATOM   1154 C  CG  . GLU A 1 175 ? -30.236 -14.261 -11.348 1.00 84.37  ? 438  GLU A CG  1 
ATOM   1155 C  CD  . GLU A 1 175 ? -28.818 -13.746 -11.486 1.00 80.39  ? 438  GLU A CD  1 
ATOM   1156 O  OE1 . GLU A 1 175 ? -27.971 -14.496 -11.996 1.00 90.74  ? 438  GLU A OE1 1 
ATOM   1157 O  OE2 . GLU A 1 175 ? -28.561 -12.612 -11.065 1.00 80.36  ? 438  GLU A OE2 1 
ATOM   1158 N  N   . ARG A 1 176 ? -32.105 -13.274 -15.308 1.00 59.34  ? 439  ARG A N   1 
ATOM   1159 C  CA  . ARG A 1 176 ? -32.062 -13.116 -16.788 1.00 61.50  ? 439  ARG A CA  1 
ATOM   1160 C  C   . ARG A 1 176 ? -32.027 -11.619 -17.116 1.00 63.18  ? 439  ARG A C   1 
ATOM   1161 O  O   . ARG A 1 176 ? -31.066 -11.184 -17.765 1.00 61.53  ? 439  ARG A O   1 
ATOM   1162 C  CB  . ARG A 1 176 ? -33.243 -13.830 -17.440 1.00 59.48  ? 439  ARG A CB  1 
ATOM   1163 C  CG  . ARG A 1 176 ? -33.089 -14.027 -18.937 1.00 62.83  ? 439  ARG A CG  1 
ATOM   1164 C  CD  . ARG A 1 176 ? -33.956 -15.176 -19.426 1.00 63.01  ? 439  ARG A CD  1 
ATOM   1165 N  NE  . ARG A 1 176 ? -34.110 -15.011 -20.856 1.00 79.73  ? 439  ARG A NE  1 
ATOM   1166 C  CZ  . ARG A 1 176 ? -35.064 -15.557 -21.599 1.00 100.95 ? 439  ARG A CZ  1 
ATOM   1167 N  NH1 . ARG A 1 176 ? -35.972 -16.354 -21.050 1.00 106.57 ? 439  ARG A NH1 1 
ATOM   1168 N  NH2 . ARG A 1 176 ? -35.089 -15.307 -22.900 1.00 93.94  ? 439  ARG A NH2 1 
ATOM   1169 N  N   . ASN A 1 177 ? -32.997 -10.843 -16.616 1.00 68.78  ? 440  ASN A N   1 
ATOM   1170 C  CA  . ASN A 1 177 ? -33.075 -9.374  -16.848 1.00 66.05  ? 440  ASN A CA  1 
ATOM   1171 C  C   . ASN A 1 177 ? -31.811 -8.700  -16.296 1.00 58.69  ? 440  ASN A C   1 
ATOM   1172 O  O   . ASN A 1 177 ? -31.277 -7.795  -16.967 1.00 57.90  ? 440  ASN A O   1 
ATOM   1173 C  CB  . ASN A 1 177 ? -34.386 -8.785  -16.315 1.00 71.54  ? 440  ASN A CB  1 
ATOM   1174 C  CG  . ASN A 1 177 ? -35.563 -9.138  -17.204 1.00 77.42  ? 440  ASN A CG  1 
ATOM   1175 O  OD1 . ASN A 1 177 ? -35.552 -8.856  -18.403 1.00 78.52  ? 440  ASN A OD1 1 
ATOM   1176 N  ND2 . ASN A 1 177 ? -36.569 -9.786  -16.641 1.00 82.09  ? 440  ASN A ND2 1 
ATOM   1177 N  N   . LEU A 1 178 ? -31.317 -9.135  -15.140 1.00 59.94  ? 441  LEU A N   1 
ATOM   1178 C  CA  . LEU A 1 178 ? -30.033 -8.618  -14.590 1.00 64.70  ? 441  LEU A CA  1 
ATOM   1179 C  C   . LEU A 1 178 ? -28.875 -8.816  -15.592 1.00 63.95  ? 441  LEU A C   1 
ATOM   1180 O  O   . LEU A 1 178 ? -28.126 -7.841  -15.843 1.00 64.91  ? 441  LEU A O   1 
ATOM   1181 C  CB  . LEU A 1 178 ? -29.748 -9.260  -13.229 1.00 67.35  ? 441  LEU A CB  1 
ATOM   1182 C  CG  . LEU A 1 178 ? -30.543 -8.682  -12.058 1.00 72.22  ? 441  LEU A CG  1 
ATOM   1183 C  CD1 . LEU A 1 178 ? -30.293 -9.475  -10.784 1.00 72.19  ? 441  LEU A CD1 1 
ATOM   1184 C  CD2 . LEU A 1 178 ? -30.205 -7.208  -11.848 1.00 76.26  ? 441  LEU A CD2 1 
ATOM   1185 N  N   . HIS A 1 179 ? -28.743 -10.022 -16.159 0.26 63.77  ? 442  HIS A N   1 
ATOM   1186 C  CA  . HIS A 1 179 ? -27.685 -10.385 -17.144 0.26 65.69  ? 442  HIS A CA  1 
ATOM   1187 C  C   . HIS A 1 179 ? -27.783 -9.484  -18.383 0.26 65.68  ? 442  HIS A C   1 
ATOM   1188 O  O   . HIS A 1 179 ? -26.721 -9.063  -18.881 0.26 66.13  ? 442  HIS A O   1 
ATOM   1189 C  CB  . HIS A 1 179 ? -27.750 -11.871 -17.536 0.26 65.55  ? 442  HIS A CB  1 
ATOM   1190 C  CG  . HIS A 1 179 ? -27.278 -12.811 -16.477 0.26 65.55  ? 442  HIS A CG  1 
ATOM   1191 N  ND1 . HIS A 1 179 ? -27.496 -14.173 -16.555 0.26 65.48  ? 442  HIS A ND1 1 
ATOM   1192 C  CD2 . HIS A 1 179 ? -26.619 -12.598 -15.317 0.26 64.95  ? 442  HIS A CD2 1 
ATOM   1193 C  CE1 . HIS A 1 179 ? -26.984 -14.758 -15.492 0.26 66.53  ? 442  HIS A CE1 1 
ATOM   1194 N  NE2 . HIS A 1 179 ? -26.440 -13.813 -14.716 0.26 65.21  ? 442  HIS A NE2 1 
ATOM   1195 N  N   . LEU A 1 180 ? -29.002 -9.203  -18.856 0.26 67.72  ? 443  LEU A N   1 
ATOM   1196 C  CA  . LEU A 1 180 ? -29.265 -8.306  -20.018 0.26 67.55  ? 443  LEU A CA  1 
ATOM   1197 C  C   . LEU A 1 180 ? -28.799 -6.880  -19.688 0.26 66.97  ? 443  LEU A C   1 
ATOM   1198 O  O   . LEU A 1 180 ? -28.435 -6.154  -20.630 0.26 67.38  ? 443  LEU A O   1 
ATOM   1199 C  CB  . LEU A 1 180 ? -30.756 -8.345  -20.371 0.26 66.14  ? 443  LEU A CB  1 
ATOM   1200 C  CG  . LEU A 1 180 ? -31.261 -9.665  -20.956 0.26 66.24  ? 443  LEU A CG  1 
ATOM   1201 C  CD1 . LEU A 1 180 ? -32.774 -9.768  -20.858 0.26 66.28  ? 443  LEU A CD1 1 
ATOM   1202 C  CD2 . LEU A 1 180 ? -30.816 -9.830  -22.401 0.26 66.81  ? 443  LEU A CD2 1 
ATOM   1203 N  N   . GLU A 1 181 ? -28.787 -6.510  -18.401 0.26 68.62  ? 444  GLU A N   1 
ATOM   1204 C  CA  . GLU A 1 181 ? -28.327 -5.187  -17.894 0.26 72.21  ? 444  GLU A CA  1 
ATOM   1205 C  C   . GLU A 1 181 ? -26.865 -5.274  -17.421 0.26 72.63  ? 444  GLU A C   1 
ATOM   1206 O  O   . GLU A 1 181 ? -26.433 -4.359  -16.692 0.26 72.47  ? 444  GLU A O   1 
ATOM   1207 C  CB  . GLU A 1 181 ? -29.251 -4.720  -16.766 0.26 75.33  ? 444  GLU A CB  1 
ATOM   1208 C  CG  . GLU A 1 181 ? -29.381 -3.210  -16.668 0.26 78.48  ? 444  GLU A CG  1 
ATOM   1209 C  CD  . GLU A 1 181 ? -30.302 -2.713  -15.564 0.26 81.10  ? 444  GLU A CD  1 
ATOM   1210 O  OE1 . GLU A 1 181 ? -30.836 -1.591  -15.707 0.26 82.69  ? 444  GLU A OE1 1 
ATOM   1211 O  OE2 . GLU A 1 181 ? -30.480 -3.442  -14.563 0.26 80.15  ? 444  GLU A OE2 1 
ATOM   1212 N  N   . GLY A 1 182 ? -26.139 -6.329  -17.817 0.26 72.50  ? 445  GLY A N   1 
ATOM   1213 C  CA  . GLY A 1 182 ? -24.692 -6.510  -17.576 0.26 68.45  ? 445  GLY A CA  1 
ATOM   1214 C  C   . GLY A 1 182 ? -24.351 -6.702  -16.105 0.26 66.40  ? 445  GLY A C   1 
ATOM   1215 O  O   . GLY A 1 182 ? -23.201 -6.403  -15.733 0.26 66.28  ? 445  GLY A O   1 
ATOM   1216 N  N   . LYS A 1 183 ? -25.298 -7.196  -15.301 0.26 64.70  ? 446  LYS A N   1 
ATOM   1217 C  CA  . LYS A 1 183 ? -25.140 -7.415  -13.835 0.26 65.35  ? 446  LYS A CA  1 
ATOM   1218 C  C   . LYS A 1 183 ? -25.473 -8.872  -13.496 0.26 62.49  ? 446  LYS A C   1 
ATOM   1219 O  O   . LYS A 1 183 ? -26.139 -9.529  -14.313 0.26 60.72  ? 446  LYS A O   1 
ATOM   1220 C  CB  . LYS A 1 183 ? -26.063 -6.482  -13.045 0.26 66.89  ? 446  LYS A CB  1 
ATOM   1221 C  CG  . LYS A 1 183 ? -25.852 -4.992  -13.276 0.26 68.78  ? 446  LYS A CG  1 
ATOM   1222 C  CD  . LYS A 1 183 ? -27.143 -4.201  -13.230 0.26 70.18  ? 446  LYS A CD  1 
ATOM   1223 C  CE  . LYS A 1 183 ? -26.938 -2.708  -13.370 0.26 71.39  ? 446  LYS A CE  1 
ATOM   1224 N  NZ  . LYS A 1 183 ? -26.693 -2.065  -12.058 0.26 71.19  ? 446  LYS A NZ  1 
ATOM   1225 N  N   . CYS A 1 184 ? -25.040 -9.338  -12.320 1.00 61.20  ? 447  CYS A N   1 
ATOM   1226 C  CA  . CYS A 1 184 ? -25.291 -10.720 -11.819 1.00 64.30  ? 447  CYS A CA  1 
ATOM   1227 C  C   . CYS A 1 184 ? -25.438 -10.646 -10.294 1.00 63.04  ? 447  CYS A C   1 
ATOM   1228 O  O   . CYS A 1 184 ? -24.723 -9.838  -9.656  1.00 65.04  ? 447  CYS A O   1 
ATOM   1229 C  CB  . CYS A 1 184 ? -24.144 -11.647 -12.238 1.00 64.95  ? 447  CYS A CB  1 
ATOM   1230 S  SG  . CYS A 1 184 ? -24.239 -13.326 -11.548 1.00 60.25  ? 447  CYS A SG  1 
ATOM   1231 N  N   . GLU A 1 185 ? -26.317 -11.480 -9.729  0.26 66.14  ? 448  GLU A N   1 
ATOM   1232 C  CA  . GLU A 1 185 ? -26.735 -11.414 -8.302  0.26 69.90  ? 448  GLU A CA  1 
ATOM   1233 C  C   . GLU A 1 185 ? -26.571 -12.779 -7.615  0.26 70.34  ? 448  GLU A C   1 
ATOM   1234 O  O   . GLU A 1 185 ? -26.029 -12.793 -6.493  0.26 71.07  ? 448  GLU A O   1 
ATOM   1235 C  CB  . GLU A 1 185 ? -28.179 -10.914 -8.221  0.26 72.55  ? 448  GLU A CB  1 
ATOM   1236 C  CG  . GLU A 1 185 ? -28.650 -10.587 -6.815  0.26 74.89  ? 448  GLU A CG  1 
ATOM   1237 C  CD  . GLU A 1 185 ? -30.022 -9.933  -6.761  0.26 76.97  ? 448  GLU A CD  1 
ATOM   1238 O  OE1 . GLU A 1 185 ? -30.148 -8.786  -7.238  0.26 75.22  ? 448  GLU A OE1 1 
ATOM   1239 O  OE2 . GLU A 1 185 ? -30.967 -10.581 -6.260  0.26 78.86  ? 448  GLU A OE2 1 
ATOM   1240 N  N   . THR A 1 186 ? -27.020 -13.874 -8.243  0.26 69.79  ? 449  THR A N   1 
ATOM   1241 C  CA  . THR A 1 186 ? -27.220 -15.190 -7.575  0.26 70.93  ? 449  THR A CA  1 
ATOM   1242 C  C   . THR A 1 186 ? -26.401 -16.318 -8.225  0.26 71.39  ? 449  THR A C   1 
ATOM   1243 O  O   . THR A 1 186 ? -26.488 -17.447 -7.702  0.26 74.11  ? 449  THR A O   1 
ATOM   1244 C  CB  . THR A 1 186 ? -28.711 -15.552 -7.543  0.26 71.70  ? 449  THR A CB  1 
ATOM   1245 O  OG1 . THR A 1 186 ? -29.173 -15.683 -8.886  0.26 71.98  ? 449  THR A OG1 1 
ATOM   1246 C  CG2 . THR A 1 186 ? -29.551 -14.521 -6.823  0.26 73.06  ? 449  THR A CG2 1 
ATOM   1247 N  N   . CYS A 1 187 ? -25.630 -16.057 -9.289  0.26 70.61  ? 450  CYS A N   1 
ATOM   1248 C  CA  . CYS A 1 187 ? -24.799 -17.087 -9.978  0.26 70.83  ? 450  CYS A CA  1 
ATOM   1249 C  C   . CYS A 1 187 ? -23.462 -17.254 -9.242  0.26 71.48  ? 450  CYS A C   1 
ATOM   1250 O  O   . CYS A 1 187 ? -22.445 -16.688 -9.702  0.26 68.96  ? 450  CYS A O   1 
ATOM   1251 C  CB  . CYS A 1 187 ? -24.578 -16.756 -11.449 0.26 70.26  ? 450  CYS A CB  1 
ATOM   1252 S  SG  . CYS A 1 187 ? -26.105 -16.782 -12.424 0.26 72.28  ? 450  CYS A SG  1 
ATOM   1253 N  N   . VAL A 1 188 ? -23.475 -18.036 -8.156  0.26 73.36  ? 451  VAL A N   1 
ATOM   1254 C  CA  . VAL A 1 188 ? -22.315 -18.281 -7.247  0.26 73.94  ? 451  VAL A CA  1 
ATOM   1255 C  C   . VAL A 1 188 ? -22.014 -19.785 -7.211  0.26 72.42  ? 451  VAL A C   1 
ATOM   1256 O  O   . VAL A 1 188 ? -22.947 -20.574 -6.961  0.26 71.47  ? 451  VAL A O   1 
ATOM   1257 C  CB  . VAL A 1 188 ? -22.599 -17.726 -5.838  0.26 74.54  ? 451  VAL A CB  1 
ATOM   1258 C  CG1 . VAL A 1 188 ? -21.503 -18.090 -4.846  0.26 75.16  ? 451  VAL A CG1 1 
ATOM   1259 C  CG2 . VAL A 1 188 ? -22.816 -16.220 -5.874  0.26 75.07  ? 451  VAL A CG2 1 
ATOM   1260 N  N   . TYR A 1 189 ? -20.752 -20.154 -7.444  0.26 73.19  ? 452  TYR A N   1 
ATOM   1261 C  CA  . TYR A 1 189 ? -20.251 -21.554 -7.423  0.26 75.26  ? 452  TYR A CA  1 
ATOM   1262 C  C   . TYR A 1 189 ? -20.056 -22.001 -5.969  0.26 78.36  ? 452  TYR A C   1 
ATOM   1263 O  O   . TYR A 1 189 ? -19.717 -21.155 -5.122  0.26 79.92  ? 452  TYR A O   1 
ATOM   1264 C  CB  . TYR A 1 189 ? -18.959 -21.670 -8.236  0.26 72.22  ? 452  TYR A CB  1 
ATOM   1265 C  CG  . TYR A 1 189 ? -19.133 -21.444 -9.717  0.26 69.96  ? 452  TYR A CG  1 
ATOM   1266 C  CD1 . TYR A 1 189 ? -19.973 -22.252 -10.465 0.26 69.66  ? 452  TYR A CD1 1 
ATOM   1267 C  CD2 . TYR A 1 189 ? -18.454 -20.431 -10.376 0.26 68.59  ? 452  TYR A CD2 1 
ATOM   1268 C  CE1 . TYR A 1 189 ? -20.144 -22.055 -11.826 0.26 69.09  ? 452  TYR A CE1 1 
ATOM   1269 C  CE2 . TYR A 1 189 ? -18.608 -20.225 -11.739 0.26 68.37  ? 452  TYR A CE2 1 
ATOM   1270 C  CZ  . TYR A 1 189 ? -19.458 -21.039 -12.467 0.26 68.58  ? 452  TYR A CZ  1 
ATOM   1271 O  OH  . TYR A 1 189 ? -19.625 -20.846 -13.808 0.26 68.48  ? 452  TYR A OH  1 
ATOM   1272 N  N   . ASN A 1 190 ? -20.287 -23.290 -5.697  0.26 82.28  ? 453  ASN A N   1 
ATOM   1273 C  CA  . ASN A 1 190 ? -20.162 -23.918 -4.353  0.26 84.65  ? 453  ASN A CA  1 
ATOM   1274 C  C   . ASN A 1 190 ? -19.113 -25.038 -4.409  0.26 86.43  ? 453  ASN A C   1 
ATOM   1275 O  O   . ASN A 1 190 ? -19.461 -26.144 -4.863  0.26 85.50  ? 453  ASN A O   1 
ATOM   1276 C  CB  . ASN A 1 190 ? -21.506 -24.460 -3.857  0.26 84.91  ? 453  ASN A CB  1 
ATOM   1277 C  CG  . ASN A 1 190 ? -22.574 -23.393 -3.735  0.26 86.19  ? 453  ASN A CG  1 
ATOM   1278 O  OD1 . ASN A 1 190 ? -22.542 -22.387 -4.441  0.26 90.56  ? 453  ASN A OD1 1 
ATOM   1279 N  ND2 . ASN A 1 190 ? -23.531 -23.607 -2.847  0.26 86.49  ? 453  ASN A ND2 1 
ATOM   1280 N  N   . MET A 1 191 ? -17.882 -24.759 -3.964  0.26 91.20  ? 454  MET A N   1 
ATOM   1281 C  CA  . MET A 1 191 ? -16.775 -25.753 -3.878  0.26 95.37  ? 454  MET A CA  1 
ATOM   1282 C  C   . MET A 1 191 ? -17.087 -26.744 -2.750  0.26 97.87  ? 454  MET A C   1 
ATOM   1283 O  O   . MET A 1 191 ? -17.491 -26.287 -1.661  0.26 97.70  ? 454  MET A O   1 
ATOM   1284 C  CB  . MET A 1 191 ? -15.429 -25.068 -3.612  0.26 98.11  ? 454  MET A CB  1 
ATOM   1285 C  CG  . MET A 1 191 ? -14.241 -26.020 -3.648  0.26 101.41 ? 454  MET A CG  1 
ATOM   1286 S  SD  . MET A 1 191 ? -12.640 -25.183 -3.452  0.26 108.14 ? 454  MET A SD  1 
ATOM   1287 C  CE  . MET A 1 191 ? -12.408 -24.507 -5.096  0.26 107.13 ? 454  MET A CE  1 
ATOM   1288 N  N   . MET A 1 192 ? -16.916 -28.045 -3.012  0.26 100.94 ? 455  MET A N   1 
ATOM   1289 C  CA  . MET A 1 192 ? -17.253 -29.154 -2.075  0.26 102.21 ? 455  MET A CA  1 
ATOM   1290 C  C   . MET A 1 192 ? -16.171 -30.239 -2.152  0.26 101.20 ? 455  MET A C   1 
ATOM   1291 O  O   . MET A 1 192 ? -15.981 -30.778 -3.260  0.26 100.98 ? 455  MET A O   1 
ATOM   1292 C  CB  . MET A 1 192 ? -18.616 -29.762 -2.420  0.26 101.72 ? 455  MET A CB  1 
ATOM   1293 C  CG  . MET A 1 192 ? -19.789 -28.904 -1.983  0.26 102.80 ? 455  MET A CG  1 
ATOM   1294 S  SD  . MET A 1 192 ? -21.297 -29.240 -2.929  0.26 105.94 ? 455  MET A SD  1 
ATOM   1295 C  CE  . MET A 1 192 ? -21.486 -31.000 -2.649  0.26 105.16 ? 455  MET A CE  1 
ATOM   1296 N  N   . ALA A 1 210 ? -17.246 -32.970 -6.809  0.26 56.34  ? 473  ALA A N   1 
ATOM   1297 C  CA  . ALA A 1 210 ? -16.489 -32.851 -8.078  0.26 56.71  ? 473  ALA A CA  1 
ATOM   1298 C  C   . ALA A 1 210 ? -17.009 -31.655 -8.890  0.26 56.19  ? 473  ALA A C   1 
ATOM   1299 O  O   . ALA A 1 210 ? -16.180 -30.958 -9.510  0.26 59.46  ? 473  ALA A O   1 
ATOM   1300 C  CB  . ALA A 1 210 ? -16.592 -34.141 -8.857  0.26 56.91  ? 473  ALA A CB  1 
ATOM   1301 N  N   . ILE A 1 211 ? -18.330 -31.437 -8.881  0.26 54.42  ? 474  ILE A N   1 
ATOM   1302 C  CA  . ILE A 1 211 ? -19.037 -30.318 -9.577  0.26 51.81  ? 474  ILE A CA  1 
ATOM   1303 C  C   . ILE A 1 211 ? -19.295 -29.208 -8.551  0.26 51.63  ? 474  ILE A C   1 
ATOM   1304 O  O   . ILE A 1 211 ? -19.541 -29.547 -7.378  0.26 53.32  ? 474  ILE A O   1 
ATOM   1305 C  CB  . ILE A 1 211 ? -20.346 -30.826 -10.221 0.26 50.59  ? 474  ILE A CB  1 
ATOM   1306 C  CG1 . ILE A 1 211 ? -20.116 -32.076 -11.074 0.26 49.98  ? 474  ILE A CG1 1 
ATOM   1307 C  CG2 . ILE A 1 211 ? -21.030 -29.729 -11.022 0.26 50.37  ? 474  ILE A CG2 1 
ATOM   1308 C  CD1 . ILE A 1 211 ? -21.371 -32.863 -11.358 0.26 49.48  ? 474  ILE A CD1 1 
ATOM   1309 N  N   . TRP A 1 212 ? -19.215 -27.939 -8.966  0.26 51.55  ? 475  TRP A N   1 
ATOM   1310 C  CA  . TRP A 1 212 ? -19.646 -26.765 -8.160  0.26 50.79  ? 475  TRP A CA  1 
ATOM   1311 C  C   . TRP A 1 212 ? -21.142 -26.535 -8.403  0.26 53.58  ? 475  TRP A C   1 
ATOM   1312 O  O   . TRP A 1 212 ? -21.479 -25.965 -9.454  0.26 57.26  ? 475  TRP A O   1 
ATOM   1313 C  CB  . TRP A 1 212 ? -18.818 -25.513 -8.495  0.26 48.52  ? 475  TRP A CB  1 
ATOM   1314 C  CG  . TRP A 1 212 ? -17.365 -25.592 -8.136  0.26 46.54  ? 475  TRP A CG  1 
ATOM   1315 C  CD1 . TRP A 1 212 ? -16.763 -26.496 -7.307  0.26 45.98  ? 475  TRP A CD1 1 
ATOM   1316 C  CD2 . TRP A 1 212 ? -16.320 -24.706 -8.582  0.26 45.27  ? 475  TRP A CD2 1 
ATOM   1317 N  NE1 . TRP A 1 212 ? -15.420 -26.244 -7.219  0.26 44.08  ? 475  TRP A NE1 1 
ATOM   1318 C  CE2 . TRP A 1 212 ? -15.118 -25.151 -7.988  0.26 44.48  ? 475  TRP A CE2 1 
ATOM   1319 C  CE3 . TRP A 1 212 ? -16.279 -23.591 -9.430  0.26 44.21  ? 475  TRP A CE3 1 
ATOM   1320 C  CZ2 . TRP A 1 212 ? -13.896 -24.519 -8.218  0.26 44.30  ? 475  TRP A CZ2 1 
ATOM   1321 C  CZ3 . TRP A 1 212 ? -15.073 -22.965 -9.654  0.26 44.61  ? 475  TRP A CZ3 1 
ATOM   1322 C  CH2 . TRP A 1 212 ? -13.897 -23.425 -9.054  0.26 45.30  ? 475  TRP A CH2 1 
ATOM   1323 N  N   . TYR A 1 213 ? -22.002 -26.969 -7.473  0.26 55.51  ? 476  TYR A N   1 
ATOM   1324 C  CA  . TYR A 1 213 ? -23.486 -26.915 -7.592  0.26 55.61  ? 476  TYR A CA  1 
ATOM   1325 C  C   . TYR A 1 213 ? -23.962 -25.465 -7.435  0.26 56.58  ? 476  TYR A C   1 
ATOM   1326 O  O   . TYR A 1 213 ? -23.454 -24.758 -6.541  0.26 61.25  ? 476  TYR A O   1 
ATOM   1327 C  CB  . TYR A 1 213 ? -24.151 -27.856 -6.582  0.26 54.21  ? 476  TYR A CB  1 
ATOM   1328 C  CG  . TYR A 1 213 ? -23.957 -29.322 -6.885  0.26 54.82  ? 476  TYR A CG  1 
ATOM   1329 C  CD1 . TYR A 1 213 ? -24.921 -30.044 -7.568  0.26 55.55  ? 476  TYR A CD1 1 
ATOM   1330 C  CD2 . TYR A 1 213 ? -22.798 -29.986 -6.514  0.26 55.09  ? 476  TYR A CD2 1 
ATOM   1331 C  CE1 . TYR A 1 213 ? -24.750 -31.388 -7.862  0.26 56.51  ? 476  TYR A CE1 1 
ATOM   1332 C  CE2 . TYR A 1 213 ? -22.610 -31.330 -6.798  0.26 56.17  ? 476  TYR A CE2 1 
ATOM   1333 C  CZ  . TYR A 1 213 ? -23.590 -32.036 -7.476  0.26 57.41  ? 476  TYR A CZ  1 
ATOM   1334 O  OH  . TYR A 1 213 ? -23.422 -33.361 -7.768  0.26 55.21  ? 476  TYR A OH  1 
ATOM   1335 N  N   . MET A 1 214 ? -24.907 -25.044 -8.287  0.26 53.78  ? 477  MET A N   1 
ATOM   1336 C  CA  . MET A 1 214 ? -25.497 -23.677 -8.312  0.26 52.84  ? 477  MET A CA  1 
ATOM   1337 C  C   . MET A 1 214 ? -26.996 -23.763 -8.007  0.26 52.79  ? 477  MET A C   1 
ATOM   1338 O  O   . MET A 1 214 ? -27.535 -24.891 -8.008  0.26 52.39  ? 477  MET A O   1 
ATOM   1339 C  CB  . MET A 1 214 ? -25.310 -23.028 -9.688  0.26 52.31  ? 477  MET A CB  1 
ATOM   1340 C  CG  . MET A 1 214 ? -24.087 -22.146 -9.792  0.26 53.03  ? 477  MET A CG  1 
ATOM   1341 S  SD  . MET A 1 214 ? -23.917 -21.418 -11.442 0.26 53.79  ? 477  MET A SD  1 
ATOM   1342 C  CE  . MET A 1 214 ? -22.764 -20.090 -11.101 0.26 51.42  ? 477  MET A CE  1 
ATOM   1343 N  N   . TRP A 1 215 ? -27.643 -22.615 -7.769  0.26 51.90  ? 478  TRP A N   1 
ATOM   1344 C  CA  . TRP A 1 215 ? -29.125 -22.500 -7.703  0.26 52.63  ? 478  TRP A CA  1 
ATOM   1345 C  C   . TRP A 1 215 ? -29.690 -22.791 -9.098  0.26 53.09  ? 478  TRP A C   1 
ATOM   1346 O  O   . TRP A 1 215 ? -29.130 -22.270 -10.080 0.26 54.34  ? 478  TRP A O   1 
ATOM   1347 C  CB  . TRP A 1 215 ? -29.565 -21.133 -7.154  0.26 52.56  ? 478  TRP A CB  1 
ATOM   1348 C  CG  . TRP A 1 215 ? -29.718 -20.045 -8.173  0.26 52.91  ? 478  TRP A CG  1 
ATOM   1349 C  CD1 . TRP A 1 215 ? -28.721 -19.377 -8.824  0.26 52.92  ? 478  TRP A CD1 1 
ATOM   1350 C  CD2 . TRP A 1 215 ? -30.953 -19.471 -8.641  0.26 52.23  ? 478  TRP A CD2 1 
ATOM   1351 N  NE1 . TRP A 1 215 ? -29.249 -18.440 -9.673  0.26 53.34  ? 478  TRP A NE1 1 
ATOM   1352 C  CE2 . TRP A 1 215 ? -30.615 -18.472 -9.580  0.26 51.91  ? 478  TRP A CE2 1 
ATOM   1353 C  CE3 . TRP A 1 215 ? -32.305 -19.705 -8.365  0.26 51.73  ? 478  TRP A CE3 1 
ATOM   1354 C  CZ2 . TRP A 1 215 ? -31.581 -17.715 -10.242 0.26 51.13  ? 478  TRP A CZ2 1 
ATOM   1355 C  CZ3 . TRP A 1 215 ? -33.258 -18.955 -9.020  0.26 52.09  ? 478  TRP A CZ3 1 
ATOM   1356 C  CH2 . TRP A 1 215 ? -32.898 -17.975 -9.945  0.26 50.88  ? 478  TRP A CH2 1 
ATOM   1357 N  N   . LEU A 1 216 ? -30.744 -23.607 -9.176  0.26 56.68  ? 479  LEU A N   1 
ATOM   1358 C  CA  . LEU A 1 216 ? -31.253 -24.216 -10.438 0.26 58.78  ? 479  LEU A CA  1 
ATOM   1359 C  C   . LEU A 1 216 ? -31.373 -23.157 -11.545 0.26 59.95  ? 479  LEU A C   1 
ATOM   1360 O  O   . LEU A 1 216 ? -31.149 -23.510 -12.719 0.26 59.92  ? 479  LEU A O   1 
ATOM   1361 C  CB  . LEU A 1 216 ? -32.601 -24.888 -10.159 0.26 58.74  ? 479  LEU A CB  1 
ATOM   1362 C  CG  . LEU A 1 216 ? -33.198 -25.673 -11.325 0.26 60.21  ? 479  LEU A CG  1 
ATOM   1363 C  CD1 . LEU A 1 216 ? -32.373 -26.919 -11.623 0.26 59.91  ? 479  LEU A CD1 1 
ATOM   1364 C  CD2 . LEU A 1 216 ? -34.640 -26.051 -11.039 0.26 60.69  ? 479  LEU A CD2 1 
ATOM   1365 N  N   . GLY A 1 217 ? -31.708 -21.913 -11.188 0.26 60.26  ? 480  GLY A N   1 
ATOM   1366 C  CA  . GLY A 1 217 ? -31.893 -20.798 -12.137 0.26 63.39  ? 480  GLY A CA  1 
ATOM   1367 C  C   . GLY A 1 217 ? -30.628 -20.478 -12.919 0.26 63.25  ? 480  GLY A C   1 
ATOM   1368 O  O   . GLY A 1 217 ? -30.739 -20.202 -14.130 0.26 63.53  ? 480  GLY A O   1 
ATOM   1369 N  N   . ALA A 1 218 ? -29.467 -20.501 -12.258 0.26 63.33  ? 481  ALA A N   1 
ATOM   1370 C  CA  . ALA A 1 218 ? -28.144 -20.226 -12.873 0.26 64.27  ? 481  ALA A CA  1 
ATOM   1371 C  C   . ALA A 1 218 ? -27.759 -21.371 -13.817 0.26 62.84  ? 481  ALA A C   1 
ATOM   1372 O  O   . ALA A 1 218 ? -27.065 -21.101 -14.817 0.26 62.32  ? 481  ALA A O   1 
ATOM   1373 C  CB  . ALA A 1 218 ? -27.100 -20.025 -11.804 0.26 63.57  ? 481  ALA A CB  1 
ATOM   1374 N  N   . ARG A 1 219 ? -28.192 -22.597 -13.505 0.26 61.64  ? 482  ARG A N   1 
ATOM   1375 C  CA  . ARG A 1 219 ? -27.909 -23.821 -14.302 0.26 61.38  ? 482  ARG A CA  1 
ATOM   1376 C  C   . ARG A 1 219 ? -28.726 -23.800 -15.596 0.26 60.55  ? 482  ARG A C   1 
ATOM   1377 O  O   . ARG A 1 219 ? -28.261 -24.399 -16.587 0.26 63.04  ? 482  ARG A O   1 
ATOM   1378 C  CB  . ARG A 1 219 ? -28.200 -25.079 -13.478 0.26 61.39  ? 482  ARG A CB  1 
ATOM   1379 C  CG  . ARG A 1 219 ? -27.210 -25.310 -12.347 0.26 62.82  ? 482  ARG A CG  1 
ATOM   1380 C  CD  . ARG A 1 219 ? -25.786 -25.207 -12.857 0.26 63.43  ? 482  ARG A CD  1 
ATOM   1381 N  NE  . ARG A 1 219 ? -24.801 -25.850 -12.002 0.26 65.35  ? 482  ARG A NE  1 
ATOM   1382 C  CZ  . ARG A 1 219 ? -23.526 -26.031 -12.330 0.26 64.48  ? 482  ARG A CZ  1 
ATOM   1383 N  NH1 . ARG A 1 219 ? -23.077 -25.628 -13.507 0.26 63.42  ? 482  ARG A NH1 1 
ATOM   1384 N  NH2 . ARG A 1 219 ? -22.707 -26.629 -11.482 0.26 64.80  ? 482  ARG A NH2 1 
ATOM   1385 N  N   . PHE A 1 220 ? -29.889 -23.143 -15.583 0.26 59.14  ? 483  PHE A N   1 
ATOM   1386 C  CA  . PHE A 1 220 ? -30.742 -22.923 -16.779 0.26 59.02  ? 483  PHE A CA  1 
ATOM   1387 C  C   . PHE A 1 220 ? -30.113 -21.839 -17.661 0.26 57.62  ? 483  PHE A C   1 
ATOM   1388 O  O   . PHE A 1 220 ? -29.907 -22.095 -18.859 0.26 57.02  ? 483  PHE A O   1 
ATOM   1389 C  CB  . PHE A 1 220 ? -32.171 -22.530 -16.396 0.26 59.19  ? 483  PHE A CB  1 
ATOM   1390 C  CG  . PHE A 1 220 ? -32.977 -22.025 -17.564 0.26 59.45  ? 483  PHE A CG  1 
ATOM   1391 C  CD1 . PHE A 1 220 ? -33.442 -22.902 -18.531 0.26 60.34  ? 483  PHE A CD1 1 
ATOM   1392 C  CD2 . PHE A 1 220 ? -33.227 -20.671 -17.728 0.26 61.22  ? 483  PHE A CD2 1 
ATOM   1393 C  CE1 . PHE A 1 220 ? -34.162 -22.439 -19.620 0.26 60.89  ? 483  PHE A CE1 1 
ATOM   1394 C  CE2 . PHE A 1 220 ? -33.949 -20.209 -18.818 0.26 60.83  ? 483  PHE A CE2 1 
ATOM   1395 C  CZ  . PHE A 1 220 ? -34.413 -21.094 -19.763 0.26 61.34  ? 483  PHE A CZ  1 
ATOM   1396 N  N   . LEU A 1 221 ? -29.837 -20.666 -17.080 0.26 57.76  ? 484  LEU A N   1 
ATOM   1397 C  CA  . LEU A 1 221 ? -29.297 -19.474 -17.792 0.26 57.41  ? 484  LEU A CA  1 
ATOM   1398 C  C   . LEU A 1 221 ? -28.001 -19.846 -18.522 0.26 55.13  ? 484  LEU A C   1 
ATOM   1399 O  O   . LEU A 1 221 ? -27.788 -19.336 -19.640 0.26 54.11  ? 484  LEU A O   1 
ATOM   1400 C  CB  . LEU A 1 221 ? -29.064 -18.341 -16.787 0.26 58.02  ? 484  LEU A CB  1 
ATOM   1401 C  CG  . LEU A 1 221 ? -30.326 -17.632 -16.295 0.26 58.18  ? 484  LEU A CG  1 
ATOM   1402 C  CD1 . LEU A 1 221 ? -30.007 -16.683 -15.151 0.26 57.99  ? 484  LEU A CD1 1 
ATOM   1403 C  CD2 . LEU A 1 221 ? -31.011 -16.882 -17.427 0.26 58.19  ? 484  LEU A CD2 1 
ATOM   1404 N  N   . GLU A 1 222 ? -27.181 -20.707 -17.913 0.26 53.65  ? 485  GLU A N   1 
ATOM   1405 C  CA  . GLU A 1 222 ? -25.940 -21.260 -18.519 0.26 52.04  ? 485  GLU A CA  1 
ATOM   1406 C  C   . GLU A 1 222 ? -26.324 -22.176 -19.690 0.26 51.00  ? 485  GLU A C   1 
ATOM   1407 O  O   . GLU A 1 222 ? -25.725 -22.035 -20.775 0.26 48.68  ? 485  GLU A O   1 
ATOM   1408 C  CB  . GLU A 1 222 ? -25.137 -22.004 -17.451 0.26 51.67  ? 485  GLU A CB  1 
ATOM   1409 C  CG  . GLU A 1 222 ? -23.724 -22.345 -17.877 0.26 51.18  ? 485  GLU A CG  1 
ATOM   1410 C  CD  . GLU A 1 222 ? -22.910 -23.057 -16.812 0.26 50.47  ? 485  GLU A CD  1 
ATOM   1411 O  OE1 . GLU A 1 222 ? -21.669 -22.996 -16.887 0.26 49.32  ? 485  GLU A OE1 1 
ATOM   1412 O  OE2 . GLU A 1 222 ? -23.519 -23.667 -15.912 0.26 49.37  ? 485  GLU A OE2 1 
ATOM   1413 N  N   . PHE A 1 223 ? -27.289 -23.073 -19.461 1.00 50.02  ? 486  PHE A N   1 
ATOM   1414 C  CA  . PHE A 1 223 ? -27.856 -24.001 -20.481 1.00 53.12  ? 486  PHE A CA  1 
ATOM   1415 C  C   . PHE A 1 223 ? -28.533 -23.236 -21.633 1.00 51.83  ? 486  PHE A C   1 
ATOM   1416 O  O   . PHE A 1 223 ? -28.448 -23.657 -22.815 1.00 48.58  ? 486  PHE A O   1 
ATOM   1417 C  CB  . PHE A 1 223 ? -28.851 -24.954 -19.817 1.00 51.86  ? 486  PHE A CB  1 
ATOM   1418 C  CG  . PHE A 1 223 ? -29.481 -25.933 -20.763 1.00 49.94  ? 486  PHE A CG  1 
ATOM   1419 C  CD1 . PHE A 1 223 ? -28.724 -26.949 -21.324 1.00 44.86  ? 486  PHE A CD1 1 
ATOM   1420 C  CD2 . PHE A 1 223 ? -30.833 -25.844 -21.080 1.00 53.72  ? 486  PHE A CD2 1 
ATOM   1421 C  CE1 . PHE A 1 223 ? -29.299 -27.857 -22.204 1.00 49.69  ? 486  PHE A CE1 1 
ATOM   1422 C  CE2 . PHE A 1 223 ? -31.422 -26.774 -21.930 1.00 48.31  ? 486  PHE A CE2 1 
ATOM   1423 C  CZ  . PHE A 1 223 ? -30.651 -27.768 -22.508 1.00 53.78  ? 486  PHE A CZ  1 
ATOM   1424 N  N   . GLU A 1 224 ? -29.198 -22.129 -21.292 0.26 52.16  ? 487  GLU A N   1 
ATOM   1425 C  CA  . GLU A 1 224 ? -29.906 -21.232 -22.245 0.26 53.55  ? 487  GLU A CA  1 
ATOM   1426 C  C   . GLU A 1 224 ? -28.897 -20.680 -23.258 0.26 52.22  ? 487  GLU A C   1 
ATOM   1427 O  O   . GLU A 1 224 ? -29.144 -20.809 -24.473 0.26 52.60  ? 487  GLU A O   1 
ATOM   1428 C  CB  . GLU A 1 224 ? -30.600 -20.099 -21.482 0.26 54.59  ? 487  GLU A CB  1 
ATOM   1429 C  CG  . GLU A 1 224 ? -31.447 -19.192 -22.356 0.26 55.67  ? 487  GLU A CG  1 
ATOM   1430 C  CD  . GLU A 1 224 ? -32.330 -18.224 -21.584 0.26 56.29  ? 487  GLU A CD  1 
ATOM   1431 O  OE1 . GLU A 1 224 ? -33.565 -18.320 -21.717 0.26 55.61  ? 487  GLU A OE1 1 
ATOM   1432 O  OE2 . GLU A 1 224 ? -31.779 -17.371 -20.857 0.26 57.49  ? 487  GLU A OE2 1 
ATOM   1433 N  N   . ALA A 1 225 ? -27.798 -20.104 -22.762 1.00 51.89  ? 488  ALA A N   1 
ATOM   1434 C  CA  . ALA A 1 225 ? -26.794 -19.400 -23.581 1.00 49.10  ? 488  ALA A CA  1 
ATOM   1435 C  C   . ALA A 1 225 ? -25.874 -20.366 -24.325 1.00 49.25  ? 488  ALA A C   1 
ATOM   1436 O  O   . ALA A 1 225 ? -25.447 -19.969 -25.466 1.00 42.52  ? 488  ALA A O   1 
ATOM   1437 C  CB  . ALA A 1 225 ? -26.020 -18.463 -22.709 1.00 49.30  ? 488  ALA A CB  1 
ATOM   1438 N  N   . LEU A 1 226 ? -25.509 -21.515 -23.725 1.00 44.57  ? 489  LEU A N   1 
ATOM   1439 C  CA  . LEU A 1 226 ? -24.365 -22.324 -24.266 1.00 44.74  ? 489  LEU A CA  1 
ATOM   1440 C  C   . LEU A 1 226 ? -24.724 -23.799 -24.500 1.00 39.19  ? 489  LEU A C   1 
ATOM   1441 O  O   . LEU A 1 226 ? -23.918 -24.481 -25.135 1.00 44.52  ? 489  LEU A O   1 
ATOM   1442 C  CB  . LEU A 1 226 ? -23.156 -22.179 -23.345 1.00 39.44  ? 489  LEU A CB  1 
ATOM   1443 C  CG  . LEU A 1 226 ? -22.689 -20.745 -23.094 1.00 44.57  ? 489  LEU A CG  1 
ATOM   1444 C  CD1 . LEU A 1 226 ? -21.590 -20.694 -22.033 1.00 44.76  ? 489  LEU A CD1 1 
ATOM   1445 C  CD2 . LEU A 1 226 ? -22.156 -20.131 -24.379 1.00 48.39  ? 489  LEU A CD2 1 
ATOM   1446 N  N   . GLY A 1 227 ? -25.878 -24.280 -24.050 1.00 36.08  ? 490  GLY A N   1 
ATOM   1447 C  CA  . GLY A 1 227 ? -26.288 -25.694 -24.187 1.00 33.53  ? 490  GLY A CA  1 
ATOM   1448 C  C   . GLY A 1 227 ? -26.237 -26.136 -25.633 1.00 33.01  ? 490  GLY A C   1 
ATOM   1449 O  O   . GLY A 1 227 ? -26.100 -27.342 -25.901 1.00 36.27  ? 490  GLY A O   1 
ATOM   1450 N  N   . PHE A 1 228 ? -26.339 -25.208 -26.584 1.00 35.38  ? 491  PHE A N   1 
ATOM   1451 C  CA  . PHE A 1 228 ? -26.377 -25.611 -28.013 1.00 38.16  ? 491  PHE A CA  1 
ATOM   1452 C  C   . PHE A 1 228 ? -25.103 -26.377 -28.365 1.00 37.95  ? 491  PHE A C   1 
ATOM   1453 O  O   . PHE A 1 228 ? -25.172 -27.267 -29.236 1.00 37.89  ? 491  PHE A O   1 
ATOM   1454 C  CB  . PHE A 1 228 ? -26.565 -24.455 -29.013 1.00 35.45  ? 491  PHE A CB  1 
ATOM   1455 C  CG  . PHE A 1 228 ? -25.444 -23.468 -29.057 1.00 34.66  ? 491  PHE A CG  1 
ATOM   1456 C  CD1 . PHE A 1 228 ? -25.314 -22.498 -28.077 1.00 39.10  ? 491  PHE A CD1 1 
ATOM   1457 C  CD2 . PHE A 1 228 ? -24.488 -23.542 -30.047 1.00 34.26  ? 491  PHE A CD2 1 
ATOM   1458 C  CE1 . PHE A 1 228 ? -24.253 -21.615 -28.096 1.00 37.97  ? 491  PHE A CE1 1 
ATOM   1459 C  CE2 . PHE A 1 228 ? -23.415 -22.671 -30.051 1.00 35.45  ? 491  PHE A CE2 1 
ATOM   1460 C  CZ  . PHE A 1 228 ? -23.287 -21.716 -29.071 1.00 35.61  ? 491  PHE A CZ  1 
ATOM   1461 N  N   . LEU A 1 229 ? -23.978 -26.005 -27.741 0.26 37.20  ? 492  LEU A N   1 
ATOM   1462 C  CA  . LEU A 1 229 ? -22.650 -26.653 -27.932 0.26 37.38  ? 492  LEU A CA  1 
ATOM   1463 C  C   . LEU A 1 229 ? -22.800 -28.158 -27.669 0.26 35.78  ? 492  LEU A C   1 
ATOM   1464 O  O   . LEU A 1 229 ? -22.356 -28.970 -28.529 0.26 36.26  ? 492  LEU A O   1 
ATOM   1465 C  CB  . LEU A 1 229 ? -21.630 -26.002 -26.989 0.26 37.57  ? 492  LEU A CB  1 
ATOM   1466 C  CG  . LEU A 1 229 ? -21.266 -24.550 -27.311 0.26 37.84  ? 492  LEU A CG  1 
ATOM   1467 C  CD1 . LEU A 1 229 ? -20.604 -23.871 -26.122 0.26 38.89  ? 492  LEU A CD1 1 
ATOM   1468 C  CD2 . LEU A 1 229 ? -20.368 -24.469 -28.533 0.26 37.65  ? 492  LEU A CD2 1 
ATOM   1469 N  N   . ASN A 1 230 ? -23.464 -28.510 -26.563 0.26 35.39  ? 493  ASN A N   1 
ATOM   1470 C  CA  . ASN A 1 230 ? -23.705 -29.914 -26.136 0.26 36.52  ? 493  ASN A CA  1 
ATOM   1471 C  C   . ASN A 1 230 ? -24.710 -30.587 -27.083 0.26 36.79  ? 493  ASN A C   1 
ATOM   1472 O  O   . ASN A 1 230 ? -24.305 -31.526 -27.801 0.26 37.47  ? 493  ASN A O   1 
ATOM   1473 C  CB  . ASN A 1 230 ? -24.175 -29.986 -24.678 0.26 35.71  ? 493  ASN A CB  1 
ATOM   1474 C  CG  . ASN A 1 230 ? -23.172 -29.411 -23.700 0.26 35.35  ? 493  ASN A CG  1 
ATOM   1475 O  OD1 . ASN A 1 230 ? -23.549 -28.843 -22.677 0.26 36.27  ? 493  ASN A OD1 1 
ATOM   1476 N  ND2 . ASN A 1 230 ? -21.894 -29.542 -24.009 0.26 34.80  ? 493  ASN A ND2 1 
ATOM   1477 N  N   . GLU A 1 231 ? -25.964 -30.122 -27.094 0.26 38.24  ? 494  GLU A N   1 
ATOM   1478 C  CA  . GLU A 1 231 ? -27.120 -30.878 -27.659 0.26 37.75  ? 494  GLU A CA  1 
ATOM   1479 C  C   . GLU A 1 231 ? -27.144 -30.811 -29.193 0.26 38.14  ? 494  GLU A C   1 
ATOM   1480 O  O   . GLU A 1 231 ? -27.779 -31.702 -29.788 0.26 38.08  ? 494  GLU A O   1 
ATOM   1481 C  CB  . GLU A 1 231 ? -28.435 -30.389 -27.050 0.26 37.85  ? 494  GLU A CB  1 
ATOM   1482 C  CG  . GLU A 1 231 ? -28.731 -31.009 -25.690 0.26 38.92  ? 494  GLU A CG  1 
ATOM   1483 C  CD  . GLU A 1 231 ? -28.837 -32.528 -25.686 0.26 38.16  ? 494  GLU A CD  1 
ATOM   1484 O  OE1 . GLU A 1 231 ? -29.897 -33.051 -26.093 0.26 36.04  ? 494  GLU A OE1 1 
ATOM   1485 O  OE2 . GLU A 1 231 ? -27.847 -33.190 -25.301 0.26 37.72  ? 494  GLU A OE2 1 
ATOM   1486 N  N   . ASP A 1 232 ? -26.477 -29.829 -29.814 0.26 37.93  ? 495  ASP A N   1 
ATOM   1487 C  CA  . ASP A 1 232 ? -26.401 -29.692 -31.296 0.26 37.53  ? 495  ASP A CA  1 
ATOM   1488 C  C   . ASP A 1 232 ? -25.076 -30.277 -31.811 0.26 38.09  ? 495  ASP A C   1 
ATOM   1489 O  O   . ASP A 1 232 ? -24.785 -30.115 -33.016 0.26 37.03  ? 495  ASP A O   1 
ATOM   1490 C  CB  . ASP A 1 232 ? -26.627 -28.239 -31.719 0.26 37.59  ? 495  ASP A CB  1 
ATOM   1491 C  CG  . ASP A 1 232 ? -28.011 -27.730 -31.348 0.26 37.19  ? 495  ASP A CG  1 
ATOM   1492 O  OD1 . ASP A 1 232 ? -28.988 -28.269 -31.896 0.26 35.18  ? 495  ASP A OD1 1 
ATOM   1493 O  OD2 . ASP A 1 232 ? -28.102 -26.818 -30.496 0.26 36.66  ? 495  ASP A OD2 1 
ATOM   1494 N  N   . HIS A 1 233 ? -24.319 -30.952 -30.938 1.00 37.40  ? 496  HIS A N   1 
ATOM   1495 C  CA  . HIS A 1 233 ? -23.154 -31.797 -31.323 1.00 43.76  ? 496  HIS A CA  1 
ATOM   1496 C  C   . HIS A 1 233 ? -22.108 -31.009 -32.107 1.00 35.89  ? 496  HIS A C   1 
ATOM   1497 O  O   . HIS A 1 233 ? -21.782 -31.414 -33.225 1.00 38.65  ? 496  HIS A O   1 
ATOM   1498 C  CB  . HIS A 1 233 ? -23.673 -32.989 -32.133 1.00 45.21  ? 496  HIS A CB  1 
ATOM   1499 C  CG  . HIS A 1 233 ? -24.745 -33.690 -31.393 1.00 51.59  ? 496  HIS A CG  1 
ATOM   1500 N  ND1 . HIS A 1 233 ? -24.588 -34.038 -30.061 1.00 66.31  ? 496  HIS A ND1 1 
ATOM   1501 C  CD2 . HIS A 1 233 ? -26.001 -34.041 -31.744 1.00 54.13  ? 496  HIS A CD2 1 
ATOM   1502 C  CE1 . HIS A 1 233 ? -25.696 -34.623 -29.636 1.00 67.23  ? 496  HIS A CE1 1 
ATOM   1503 N  NE2 . HIS A 1 233 ? -26.570 -34.641 -30.656 1.00 51.61  ? 496  HIS A NE2 1 
ATOM   1504 N  N   . TRP A 1 234 ? -21.708 -29.867 -31.588 1.00 35.55  ? 497  TRP A N   1 
ATOM   1505 C  CA  . TRP A 1 234 ? -20.691 -29.003 -32.252 1.00 41.30  ? 497  TRP A CA  1 
ATOM   1506 C  C   . TRP A 1 234 ? -19.344 -29.756 -32.354 1.00 38.41  ? 497  TRP A C   1 
ATOM   1507 O  O   . TRP A 1 234 ? -18.614 -29.559 -33.380 1.00 32.03  ? 497  TRP A O   1 
ATOM   1508 C  CB  . TRP A 1 234 ? -20.601 -27.645 -31.529 1.00 41.52  ? 497  TRP A CB  1 
ATOM   1509 C  CG  . TRP A 1 234 ? -21.646 -26.688 -32.018 1.00 48.75  ? 497  TRP A CG  1 
ATOM   1510 C  CD1 . TRP A 1 234 ? -22.989 -26.932 -32.078 1.00 46.52  ? 497  TRP A CD1 1 
ATOM   1511 C  CD2 . TRP A 1 234 ? -21.455 -25.357 -32.549 1.00 49.62  ? 497  TRP A CD2 1 
ATOM   1512 N  NE1 . TRP A 1 234 ? -23.637 -25.867 -32.634 1.00 46.58  ? 497  TRP A NE1 1 
ATOM   1513 C  CE2 . TRP A 1 234 ? -22.737 -24.871 -32.905 1.00 53.05  ? 497  TRP A CE2 1 
ATOM   1514 C  CE3 . TRP A 1 234 ? -20.350 -24.525 -32.762 1.00 46.89  ? 497  TRP A CE3 1 
ATOM   1515 C  CZ2 . TRP A 1 234 ? -22.937 -23.595 -33.451 1.00 47.26  ? 497  TRP A CZ2 1 
ATOM   1516 C  CZ3 . TRP A 1 234 ? -20.546 -23.270 -33.313 1.00 50.16  ? 497  TRP A CZ3 1 
ATOM   1517 C  CH2 . TRP A 1 234 ? -21.824 -22.812 -33.648 1.00 48.81  ? 497  TRP A CH2 1 
ATOM   1518 N  N   . PHE A 1 235 ? -19.068 -30.661 -31.397 1.00 37.11  ? 498  PHE A N   1 
ATOM   1519 C  CA  . PHE A 1 235 ? -17.802 -31.423 -31.284 1.00 37.62  ? 498  PHE A CA  1 
ATOM   1520 C  C   . PHE A 1 235 ? -17.976 -32.865 -31.770 1.00 37.62  ? 498  PHE A C   1 
ATOM   1521 O  O   . PHE A 1 235 ? -17.137 -33.713 -31.448 1.00 41.89  ? 498  PHE A O   1 
ATOM   1522 C  CB  . PHE A 1 235 ? -17.290 -31.208 -29.863 1.00 34.39  ? 498  PHE A CB  1 
ATOM   1523 C  CG  . PHE A 1 235 ? -16.961 -29.752 -29.664 1.00 36.93  ? 498  PHE A CG  1 
ATOM   1524 C  CD1 . PHE A 1 235 ? -15.904 -29.184 -30.357 1.00 36.18  ? 498  PHE A CD1 1 
ATOM   1525 C  CD2 . PHE A 1 235 ? -17.760 -28.926 -28.895 1.00 37.47  ? 498  PHE A CD2 1 
ATOM   1526 C  CE1 . PHE A 1 235 ? -15.637 -27.830 -30.256 1.00 41.09  ? 498  PHE A CE1 1 
ATOM   1527 C  CE2 . PHE A 1 235 ? -17.488 -27.564 -28.799 1.00 36.59  ? 498  PHE A CE2 1 
ATOM   1528 C  CZ  . PHE A 1 235 ? -16.427 -27.024 -29.470 1.00 38.55  ? 498  PHE A CZ  1 
ATOM   1529 N  N   . SER A 1 236 ? -19.006 -33.144 -32.562 1.00 34.48  ? 499  SER A N   1 
ATOM   1530 C  CA  . SER A 1 236 ? -19.178 -34.424 -33.277 1.00 36.79  ? 499  SER A CA  1 
ATOM   1531 C  C   . SER A 1 236 ? -17.957 -34.605 -34.176 1.00 32.79  ? 499  SER A C   1 
ATOM   1532 O  O   . SER A 1 236 ? -17.438 -33.599 -34.635 1.00 34.43  ? 499  SER A O   1 
ATOM   1533 C  CB  . SER A 1 236 ? -20.448 -34.438 -34.126 1.00 39.31  ? 499  SER A CB  1 
ATOM   1534 O  OG  . SER A 1 236 ? -20.306 -33.579 -35.273 1.00 39.88  ? 499  SER A OG  1 
ATOM   1535 N  N   . ARG A 1 237 ? -17.620 -35.825 -34.585 1.00 35.37  ? 500  ARG A N   1 
ATOM   1536 C  CA  . ARG A 1 237 ? -16.514 -35.965 -35.551 1.00 40.81  ? 500  ARG A CA  1 
ATOM   1537 C  C   . ARG A 1 237 ? -16.866 -35.351 -36.915 1.00 42.69  ? 500  ARG A C   1 
ATOM   1538 O  O   . ARG A 1 237 ? -15.967 -34.710 -37.556 1.00 36.90  ? 500  ARG A O   1 
ATOM   1539 C  CB  . ARG A 1 237 ? -16.083 -37.413 -35.736 1.00 43.44  ? 500  ARG A CB  1 
ATOM   1540 C  CG  . ARG A 1 237 ? -14.694 -37.483 -36.359 1.00 40.47  ? 500  ARG A CG  1 
ATOM   1541 C  CD  . ARG A 1 237 ? -13.954 -38.707 -35.932 1.00 37.36  ? 500  ARG A CD  1 
ATOM   1542 N  NE  . ARG A 1 237 ? -12.592 -38.606 -36.381 1.00 35.27  ? 500  ARG A NE  1 
ATOM   1543 C  CZ  . ARG A 1 237 ? -11.618 -38.007 -35.736 1.00 33.03  ? 500  ARG A CZ  1 
ATOM   1544 N  NH1 . ARG A 1 237 ? -11.817 -37.418 -34.569 1.00 33.16  ? 500  ARG A NH1 1 
ATOM   1545 N  NH2 . ARG A 1 237 ? -10.411 -38.048 -36.258 1.00 35.12  ? 500  ARG A NH2 1 
ATOM   1546 N  N   . GLU A 1 238 ? -18.081 -35.576 -37.387 1.00 40.36  ? 501  GLU A N   1 
ATOM   1547 C  CA  . GLU A 1 238 ? -18.567 -35.062 -38.703 1.00 44.88  ? 501  GLU A CA  1 
ATOM   1548 C  C   . GLU A 1 238 ? -18.385 -33.547 -38.800 1.00 39.22  ? 501  GLU A C   1 
ATOM   1549 O  O   . GLU A 1 238 ? -17.983 -33.076 -39.836 1.00 43.82  ? 501  GLU A O   1 
ATOM   1550 C  CB  . GLU A 1 238 ? -20.052 -35.428 -38.928 1.00 58.41  ? 501  GLU A CB  1 
ATOM   1551 C  CG  . GLU A 1 238 ? -20.563 -35.177 -40.346 1.00 66.43  ? 501  GLU A CG  1 
ATOM   1552 C  CD  . GLU A 1 238 ? -21.718 -36.066 -40.821 1.00 82.07  ? 501  GLU A CD  1 
ATOM   1553 O  OE1 . GLU A 1 238 ? -22.060 -36.027 -42.029 1.00 87.47  ? 501  GLU A OE1 1 
ATOM   1554 O  OE2 . GLU A 1 238 ? -22.283 -36.808 -39.994 1.00 94.17  ? 501  GLU A OE2 1 
ATOM   1555 N  N   . ASN A 1 239 ? -18.676 -32.818 -37.719 0.26 40.93  ? 502  ASN A N   1 
ATOM   1556 C  CA  . ASN A 1 239 ? -18.720 -31.330 -37.711 0.26 40.64  ? 502  ASN A CA  1 
ATOM   1557 C  C   . ASN A 1 239 ? -17.331 -30.731 -37.448 0.26 39.87  ? 502  ASN A C   1 
ATOM   1558 O  O   . ASN A 1 239 ? -16.995 -29.741 -38.128 0.26 39.99  ? 502  ASN A O   1 
ATOM   1559 C  CB  . ASN A 1 239 ? -19.697 -30.787 -36.668 0.26 40.49  ? 502  ASN A CB  1 
ATOM   1560 C  CG  . ASN A 1 239 ? -19.929 -29.303 -36.841 0.26 41.71  ? 502  ASN A CG  1 
ATOM   1561 O  OD1 . ASN A 1 239 ? -20.297 -28.857 -37.925 0.26 42.59  ? 502  ASN A OD1 1 
ATOM   1562 N  ND2 . ASN A 1 239 ? -19.693 -28.529 -35.793 0.26 42.18  ? 502  ASN A ND2 1 
ATOM   1563 N  N   . SER A 1 240 ? -16.585 -31.270 -36.474 0.26 38.18  ? 503  SER A N   1 
ATOM   1564 C  CA  . SER A 1 240 ? -15.333 -30.678 -35.922 0.26 36.91  ? 503  SER A CA  1 
ATOM   1565 C  C   . SER A 1 240 ? -14.079 -31.366 -36.480 0.26 35.91  ? 503  SER A C   1 
ATOM   1566 O  O   . SER A 1 240 ? -13.000 -30.759 -36.376 0.26 36.27  ? 503  SER A O   1 
ATOM   1567 C  CB  . SER A 1 240 ? -15.332 -30.724 -34.415 0.26 37.52  ? 503  SER A CB  1 
ATOM   1568 O  OG  . SER A 1 240 ? -15.191 -32.059 -33.947 0.26 36.98  ? 503  SER A OG  1 
ATOM   1569 N  N   . LEU A 1 241 ? -14.216 -32.584 -37.016 1.00 34.97  ? 504  LEU A N   1 
ATOM   1570 C  CA  . LEU A 1 241 ? -13.117 -33.393 -37.649 1.00 36.41  ? 504  LEU A CA  1 
ATOM   1571 C  C   . LEU A 1 241 ? -12.140 -34.007 -36.626 1.00 37.77  ? 504  LEU A C   1 
ATOM   1572 O  O   . LEU A 1 241 ? -11.693 -35.143 -36.846 1.00 35.43  ? 504  LEU A O   1 
ATOM   1573 C  CB  . LEU A 1 241 ? -12.381 -32.600 -38.731 1.00 42.87  ? 504  LEU A CB  1 
ATOM   1574 C  CG  . LEU A 1 241 ? -13.212 -31.986 -39.868 1.00 48.44  ? 504  LEU A CG  1 
ATOM   1575 C  CD1 . LEU A 1 241 ? -12.295 -31.247 -40.853 1.00 48.01  ? 504  LEU A CD1 1 
ATOM   1576 C  CD2 . LEU A 1 241 ? -13.982 -33.033 -40.631 1.00 53.63  ? 504  LEU A CD2 1 
ATOM   1577 N  N   . SER A 1 242 ? -11.835 -33.273 -35.549 0.26 35.96  ? 505  SER A N   1 
ATOM   1578 C  CA  . SER A 1 242 ? -10.991 -33.730 -34.414 0.26 36.44  ? 505  SER A CA  1 
ATOM   1579 C  C   . SER A 1 242 ? -11.857 -34.385 -33.333 0.26 34.84  ? 505  SER A C   1 
ATOM   1580 O  O   . SER A 1 242 ? -11.385 -35.351 -32.718 0.26 35.01  ? 505  SER A O   1 
ATOM   1581 C  CB  . SER A 1 242 ? -10.186 -32.591 -33.836 0.26 36.57  ? 505  SER A CB  1 
ATOM   1582 O  OG  . SER A 1 242 ? -9.449  -31.932 -34.847 0.26 36.74  ? 505  SER A OG  1 
ATOM   1583 N  N   . GLY A 1 243 ? -13.068 -33.864 -33.110 1.00 35.81  ? 506  GLY A N   1 
ATOM   1584 C  CA  . GLY A 1 243 ? -13.944 -34.275 -31.989 1.00 30.60  ? 506  GLY A CA  1 
ATOM   1585 C  C   . GLY A 1 243 ? -14.412 -35.702 -32.084 1.00 30.54  ? 506  GLY A C   1 
ATOM   1586 O  O   . GLY A 1 243 ? -14.335 -36.329 -33.197 1.00 28.56  ? 506  GLY A O   1 
ATOM   1587 N  N   . VAL A 1 244 ? -14.835 -36.216 -30.936 1.00 28.59  ? 507  VAL A N   1 
ATOM   1588 C  CA  . VAL A 1 244 ? -15.510 -37.540 -30.817 1.00 35.91  ? 507  VAL A CA  1 
ATOM   1589 C  C   . VAL A 1 244 ? -16.819 -37.500 -29.953 1.00 35.12  ? 507  VAL A C   1 
ATOM   1590 O  O   . VAL A 1 244 ? -17.233 -38.546 -29.429 1.00 31.55  ? 507  VAL A O   1 
ATOM   1591 C  CB  . VAL A 1 244 ? -14.496 -38.520 -30.209 1.00 33.24  ? 507  VAL A CB  1 
ATOM   1592 C  CG1 . VAL A 1 244 ? -13.299 -38.731 -31.096 1.00 35.85  ? 507  VAL A CG1 1 
ATOM   1593 C  CG2 . VAL A 1 244 ? -14.030 -38.033 -28.858 1.00 35.58  ? 507  VAL A CG2 1 
ATOM   1594 N  N   . GLU A 1 245 ? -17.438 -36.324 -29.823 0.26 33.69  ? 508  GLU A N   1 
ATOM   1595 C  CA  . GLU A 1 245 ? -18.666 -36.115 -29.005 0.26 34.57  ? 508  GLU A CA  1 
ATOM   1596 C  C   . GLU A 1 245 ? -19.795 -37.000 -29.543 0.26 35.12  ? 508  GLU A C   1 
ATOM   1597 O  O   . GLU A 1 245 ? -20.049 -36.939 -30.771 0.26 33.44  ? 508  GLU A O   1 
ATOM   1598 C  CB  . GLU A 1 245 ? -19.094 -34.652 -29.059 0.26 33.95  ? 508  GLU A CB  1 
ATOM   1599 C  CG  . GLU A 1 245 ? -20.030 -34.247 -27.942 0.26 33.54  ? 508  GLU A CG  1 
ATOM   1600 C  CD  . GLU A 1 245 ? -20.319 -32.759 -27.965 0.26 33.26  ? 508  GLU A CD  1 
ATOM   1601 O  OE1 . GLU A 1 245 ? -20.920 -32.299 -28.959 0.26 32.25  ? 508  GLU A OE1 1 
ATOM   1602 O  OE2 . GLU A 1 245 ? -19.895 -32.062 -27.020 0.26 31.85  ? 508  GLU A OE2 1 
ATOM   1603 N  N   . GLY A 1 246 ? -20.435 -37.797 -28.677 1.00 35.51  ? 509  GLY A N   1 
ATOM   1604 C  CA  . GLY A 1 246 ? -21.513 -38.692 -29.120 1.00 40.71  ? 509  GLY A CA  1 
ATOM   1605 C  C   . GLY A 1 246 ? -20.994 -39.885 -29.919 1.00 41.52  ? 509  GLY A C   1 
ATOM   1606 O  O   . GLY A 1 246 ? -21.838 -40.635 -30.398 1.00 41.03  ? 509  GLY A O   1 
ATOM   1607 N  N   . GLU A 1 247 ? -19.683 -40.108 -30.086 1.00 39.07  ? 510  GLU A N   1 
ATOM   1608 C  CA  . GLU A 1 247 ? -19.263 -41.206 -31.004 1.00 43.59  ? 510  GLU A CA  1 
ATOM   1609 C  C   . GLU A 1 247 ? -19.514 -42.549 -30.296 1.00 42.90  ? 510  GLU A C   1 
ATOM   1610 O  O   . GLU A 1 247 ? -19.938 -43.486 -30.984 1.00 46.09  ? 510  GLU A O   1 
ATOM   1611 C  CB  . GLU A 1 247 ? -17.816 -41.125 -31.510 1.00 41.13  ? 510  GLU A CB  1 
ATOM   1612 C  CG  . GLU A 1 247 ? -17.570 -39.929 -32.394 1.00 47.52  ? 510  GLU A CG  1 
ATOM   1613 C  CD  . GLU A 1 247 ? -18.500 -39.748 -33.582 1.00 54.78  ? 510  GLU A CD  1 
ATOM   1614 O  OE1 . GLU A 1 247 ? -18.725 -40.784 -34.267 1.00 46.46  ? 510  GLU A OE1 1 
ATOM   1615 O  OE2 . GLU A 1 247 ? -18.989 -38.540 -33.826 1.00 49.88  ? 510  GLU A OE2 1 
ATOM   1616 N  N   . GLY A 1 248 ? -19.261 -42.672 -28.995 1.00 37.60  ? 511  GLY A N   1 
ATOM   1617 C  CA  . GLY A 1 248 ? -19.438 -43.993 -28.356 1.00 39.61  ? 511  GLY A CA  1 
ATOM   1618 C  C   . GLY A 1 248 ? -18.145 -44.817 -28.350 1.00 41.27  ? 511  GLY A C   1 
ATOM   1619 O  O   . GLY A 1 248 ? -17.345 -44.777 -29.326 1.00 36.37  ? 511  GLY A O   1 
ATOM   1620 N  N   A LEU A 1 249 ? -17.970 -45.594 -27.286 0.25 39.03  ? 512  LEU A N   1 
ATOM   1621 N  N   B LEU A 1 249 ? -17.929 -45.538 -27.244 0.25 40.46  ? 512  LEU A N   1 
ATOM   1622 C  CA  A LEU A 1 249 ? -16.725 -46.324 -26.957 0.25 38.79  ? 512  LEU A CA  1 
ATOM   1623 C  CA  B LEU A 1 249 ? -16.714 -46.346 -26.959 0.25 40.99  ? 512  LEU A CA  1 
ATOM   1624 C  C   A LEU A 1 249 ? -16.457 -47.432 -27.983 0.25 39.32  ? 512  LEU A C   1 
ATOM   1625 C  C   B LEU A 1 249 ? -16.432 -47.292 -28.125 0.25 40.30  ? 512  LEU A C   1 
ATOM   1626 O  O   A LEU A 1 249 ? -15.305 -47.904 -28.043 0.25 40.34  ? 512  LEU A O   1 
ATOM   1627 O  O   B LEU A 1 249 ? -15.244 -47.479 -28.450 0.25 41.29  ? 512  LEU A O   1 
ATOM   1628 C  CB  A LEU A 1 249 ? -16.901 -46.892 -25.549 0.25 37.87  ? 512  LEU A CB  1 
ATOM   1629 C  CB  B LEU A 1 249 ? -16.930 -47.149 -25.673 0.25 41.97  ? 512  LEU A CB  1 
ATOM   1630 C  CG  A LEU A 1 249 ? -15.681 -47.604 -24.985 0.25 36.18  ? 512  LEU A CG  1 
ATOM   1631 C  CG  B LEU A 1 249 ? -16.274 -46.582 -24.419 0.25 41.67  ? 512  LEU A CG  1 
ATOM   1632 C  CD1 A LEU A 1 249 ? -14.488 -46.659 -24.930 0.25 37.15  ? 512  LEU A CD1 1 
ATOM   1633 C  CD1 B LEU A 1 249 ? -16.403 -47.563 -23.268 0.25 41.57  ? 512  LEU A CD1 1 
ATOM   1634 C  CD2 A LEU A 1 249 ? -15.997 -48.173 -23.616 0.25 35.76  ? 512  LEU A CD2 1 
ATOM   1635 C  CD2 B LEU A 1 249 ? -14.814 -46.238 -24.677 0.25 42.16  ? 512  LEU A CD2 1 
ATOM   1636 N  N   . HIS A 1 250 ? -17.486 -47.856 -28.720 1.00 37.97  ? 513  HIS A N   1 
ATOM   1637 C  CA  . HIS A 1 250 ? -17.375 -48.857 -29.815 1.00 35.52  ? 513  HIS A CA  1 
ATOM   1638 C  C   . HIS A 1 250 ? -16.949 -48.198 -31.129 1.00 35.26  ? 513  HIS A C   1 
ATOM   1639 O  O   . HIS A 1 250 ? -16.792 -48.946 -32.138 1.00 35.41  ? 513  HIS A O   1 
ATOM   1640 C  CB  . HIS A 1 250 ? -18.732 -49.596 -29.968 1.00 41.83  ? 513  HIS A CB  1 
ATOM   1641 C  CG  . HIS A 1 250 ? -19.876 -48.688 -30.259 1.00 39.08  ? 513  HIS A CG  1 
ATOM   1642 N  ND1 . HIS A 1 250 ? -20.425 -47.868 -29.289 1.00 41.79  ? 513  HIS A ND1 1 
ATOM   1643 C  CD2 . HIS A 1 250 ? -20.513 -48.413 -31.418 1.00 40.06  ? 513  HIS A CD2 1 
ATOM   1644 C  CE1 . HIS A 1 250 ? -21.345 -47.106 -29.853 1.00 43.31  ? 513  HIS A CE1 1 
ATOM   1645 N  NE2 . HIS A 1 250 ? -21.425 -47.438 -31.162 1.00 41.92  ? 513  HIS A NE2 1 
ATOM   1646 N  N   . LYS A 1 251 ? -16.828 -46.858 -31.170 1.00 36.13  ? 514  LYS A N   1 
ATOM   1647 C  CA  . LYS A 1 251 ? -16.339 -46.158 -32.387 1.00 38.88  ? 514  LYS A CA  1 
ATOM   1648 C  C   . LYS A 1 251 ? -14.900 -45.639 -32.196 1.00 35.79  ? 514  LYS A C   1 
ATOM   1649 O  O   . LYS A 1 251 ? -14.254 -45.493 -33.218 1.00 30.66  ? 514  LYS A O   1 
ATOM   1650 C  CB  . LYS A 1 251 ? -17.313 -45.063 -32.816 1.00 43.56  ? 514  LYS A CB  1 
ATOM   1651 C  CG  . LYS A 1 251 ? -18.778 -45.476 -32.724 1.00 50.24  ? 514  LYS A CG  1 
ATOM   1652 C  CD  . LYS A 1 251 ? -19.505 -45.517 -34.003 1.00 52.99  ? 514  LYS A CD  1 
ATOM   1653 C  CE  . LYS A 1 251 ? -19.881 -44.134 -34.464 1.00 57.54  ? 514  LYS A CE  1 
ATOM   1654 N  NZ  . LYS A 1 251 ? -20.931 -44.216 -35.502 1.00 60.02  ? 514  LYS A NZ  1 
ATOM   1655 N  N   . LEU A 1 252 ? -14.459 -45.319 -30.980 1.00 31.73  ? 515  LEU A N   1 
ATOM   1656 C  CA  . LEU A 1 252 ? -13.172 -44.615 -30.713 1.00 36.09  ? 515  LEU A CA  1 
ATOM   1657 C  C   . LEU A 1 252 ? -12.013 -45.422 -31.329 1.00 33.07  ? 515  LEU A C   1 
ATOM   1658 O  O   . LEU A 1 252 ? -11.156 -44.807 -31.977 1.00 35.56  ? 515  LEU A O   1 
ATOM   1659 C  CB  . LEU A 1 252 ? -13.000 -44.427 -29.198 1.00 31.64  ? 515  LEU A CB  1 
ATOM   1660 C  CG  . LEU A 1 252 ? -14.043 -43.537 -28.529 1.00 32.39  ? 515  LEU A CG  1 
ATOM   1661 C  CD1 . LEU A 1 252 ? -13.653 -43.186 -27.101 1.00 33.33  ? 515  LEU A CD1 1 
ATOM   1662 C  CD2 . LEU A 1 252 ? -14.250 -42.275 -29.309 1.00 32.22  ? 515  LEU A CD2 1 
ATOM   1663 N  N   . GLY A 1 253 ? -12.039 -46.759 -31.199 1.00 30.46  ? 516  GLY A N   1 
ATOM   1664 C  CA  . GLY A 1 253 ? -11.011 -47.651 -31.768 1.00 33.72  ? 516  GLY A CA  1 
ATOM   1665 C  C   . GLY A 1 253 ? -10.896 -47.524 -33.287 1.00 32.97  ? 516  GLY A C   1 
ATOM   1666 O  O   . GLY A 1 253 ? -9.769  -47.388 -33.790 1.00 34.82  ? 516  GLY A O   1 
ATOM   1667 N  N   . TYR A 1 254 ? -12.020 -47.550 -33.981 1.00 30.49  ? 517  TYR A N   1 
ATOM   1668 C  CA  . TYR A 1 254 ? -12.112 -47.393 -35.446 1.00 31.34  ? 517  TYR A CA  1 
ATOM   1669 C  C   . TYR A 1 254 ? -11.624 -46.004 -35.821 1.00 34.16  ? 517  TYR A C   1 
ATOM   1670 O  O   . TYR A 1 254 ? -10.901 -45.876 -36.840 1.00 34.16  ? 517  TYR A O   1 
ATOM   1671 C  CB  . TYR A 1 254 ? -13.542 -47.571 -35.944 1.00 33.55  ? 517  TYR A CB  1 
ATOM   1672 C  CG  . TYR A 1 254 ? -14.002 -49.002 -36.002 1.00 32.57  ? 517  TYR A CG  1 
ATOM   1673 C  CD1 . TYR A 1 254 ? -13.454 -49.890 -36.910 1.00 33.94  ? 517  TYR A CD1 1 
ATOM   1674 C  CD2 . TYR A 1 254 ? -14.982 -49.470 -35.136 1.00 32.13  ? 517  TYR A CD2 1 
ATOM   1675 C  CE1 . TYR A 1 254 ? -13.850 -51.223 -36.961 1.00 35.14  ? 517  TYR A CE1 1 
ATOM   1676 C  CE2 . TYR A 1 254 ? -15.409 -50.788 -35.191 1.00 34.12  ? 517  TYR A CE2 1 
ATOM   1677 C  CZ  . TYR A 1 254 ? -14.862 -51.661 -36.122 1.00 37.84  ? 517  TYR A CZ  1 
ATOM   1678 O  OH  . TYR A 1 254 ? -15.315 -52.955 -36.180 1.00 37.59  ? 517  TYR A OH  1 
ATOM   1679 N  N   . ILE A 1 255 ? -11.913 -45.019 -34.977 1.00 28.98  ? 518  ILE A N   1 
ATOM   1680 C  CA  . ILE A 1 255 ? -11.482 -43.630 -35.271 1.00 34.80  ? 518  ILE A CA  1 
ATOM   1681 C  C   . ILE A 1 255 ? -9.950  -43.545 -35.186 1.00 36.74  ? 518  ILE A C   1 
ATOM   1682 O  O   . ILE A 1 255 ? -9.360  -42.997 -36.156 1.00 36.97  ? 518  ILE A O   1 
ATOM   1683 C  CB  . ILE A 1 255 ? -12.223 -42.617 -34.389 1.00 36.41  ? 518  ILE A CB  1 
ATOM   1684 C  CG1 . ILE A 1 255 ? -13.683 -42.476 -34.871 1.00 38.10  ? 518  ILE A CG1 1 
ATOM   1685 C  CG2 . ILE A 1 255 ? -11.492 -41.284 -34.338 1.00 33.09  ? 518  ILE A CG2 1 
ATOM   1686 C  CD1 . ILE A 1 255 ? -14.591 -41.765 -33.891 1.00 36.96  ? 518  ILE A CD1 1 
ATOM   1687 N  N   . LEU A 1 256 ? -9.338  -44.074 -34.117 1.00 32.37  ? 519  LEU A N   1 
ATOM   1688 C  CA  . LEU A 1 256 ? -7.866  -44.093 -33.959 1.00 35.85  ? 519  LEU A CA  1 
ATOM   1689 C  C   . LEU A 1 256 ? -7.210  -44.869 -35.101 1.00 34.46  ? 519  LEU A C   1 
ATOM   1690 O  O   . LEU A 1 256 ? -6.114  -44.455 -35.514 1.00 35.88  ? 519  LEU A O   1 
ATOM   1691 C  CB  . LEU A 1 256 ? -7.462  -44.727 -32.629 1.00 35.62  ? 519  LEU A CB  1 
ATOM   1692 C  CG  . LEU A 1 256 ? -7.882  -43.980 -31.375 1.00 38.61  ? 519  LEU A CG  1 
ATOM   1693 C  CD1 . LEU A 1 256 ? -7.256  -44.639 -30.159 1.00 44.19  ? 519  LEU A CD1 1 
ATOM   1694 C  CD2 . LEU A 1 256 ? -7.500  -42.515 -31.433 1.00 44.07  ? 519  LEU A CD2 1 
ATOM   1695 N  N   . ARG A 1 257 ? -7.799  -45.982 -35.542 1.00 37.40  ? 520  ARG A N   1 
ATOM   1696 C  CA  . ARG A 1 257 ? -7.258  -46.769 -36.687 1.00 38.16  ? 520  ARG A CA  1 
ATOM   1697 C  C   . ARG A 1 257 ? -7.323  -45.955 -37.976 1.00 37.46  ? 520  ARG A C   1 
ATOM   1698 O  O   . ARG A 1 257 ? -6.403  -46.150 -38.798 1.00 36.74  ? 520  ARG A O   1 
ATOM   1699 C  CB  . ARG A 1 257 ? -7.957  -48.099 -36.925 1.00 34.86  ? 520  ARG A CB  1 
ATOM   1700 C  CG  . ARG A 1 257 ? -7.297  -48.957 -38.004 1.00 37.11  ? 520  ARG A CG  1 
ATOM   1701 C  CD  . ARG A 1 257 ? -7.996  -50.302 -38.201 1.00 35.48  ? 520  ARG A CD  1 
ATOM   1702 N  NE  . ARG A 1 257 ? -9.349  -50.091 -38.737 1.00 38.98  ? 520  ARG A NE  1 
ATOM   1703 C  CZ  . ARG A 1 257 ? -10.200 -51.037 -39.113 1.00 37.87  ? 520  ARG A CZ  1 
ATOM   1704 N  NH1 . ARG A 1 257 ? -9.920  -52.326 -38.987 1.00 40.01  ? 520  ARG A NH1 1 
ATOM   1705 N  NH2 . ARG A 1 257 ? -11.339 -50.669 -39.646 1.00 44.37  ? 520  ARG A NH2 1 
ATOM   1706 N  N   . ASP A 1 258 ? -8.358  -45.132 -38.168 1.00 38.64  ? 521  ASP A N   1 
ATOM   1707 C  CA  . ASP A 1 258 ? -8.444  -44.227 -39.361 1.00 41.78  ? 521  ASP A CA  1 
ATOM   1708 C  C   . ASP A 1 258 ? -7.331  -43.158 -39.280 1.00 39.17  ? 521  ASP A C   1 
ATOM   1709 O  O   . ASP A 1 258 ? -6.723  -42.872 -40.284 1.00 42.34  ? 521  ASP A O   1 
ATOM   1710 C  CB  . ASP A 1 258 ? -9.836  -43.609 -39.560 1.00 40.08  ? 521  ASP A CB  1 
ATOM   1711 C  CG  . ASP A 1 258 ? -10.885 -44.515 -40.226 1.00 43.74  ? 521  ASP A CG  1 
ATOM   1712 O  OD1 . ASP A 1 258 ? -10.521 -45.591 -40.735 1.00 41.58  ? 521  ASP A OD1 1 
ATOM   1713 O  OD2 . ASP A 1 258 ? -12.089 -44.144 -40.196 1.00 42.24  ? 521  ASP A OD2 1 
ATOM   1714 N  N   . VAL A 1 259 ? -7.082  -42.558 -38.122 1.00 37.38  ? 522  VAL A N   1 
ATOM   1715 C  CA  . VAL A 1 259 ? -5.967  -41.601 -37.958 1.00 39.59  ? 522  VAL A CA  1 
ATOM   1716 C  C   . VAL A 1 259 ? -4.665  -42.314 -38.340 1.00 37.79  ? 522  VAL A C   1 
ATOM   1717 O  O   . VAL A 1 259 ? -3.933  -41.740 -39.063 1.00 44.16  ? 522  VAL A O   1 
ATOM   1718 C  CB  . VAL A 1 259 ? -5.888  -41.068 -36.531 1.00 38.69  ? 522  VAL A CB  1 
ATOM   1719 C  CG1 . VAL A 1 259 ? -4.614  -40.232 -36.362 1.00 36.38  ? 522  VAL A CG1 1 
ATOM   1720 C  CG2 . VAL A 1 259 ? -7.145  -40.276 -36.220 1.00 40.10  ? 522  VAL A CG2 1 
ATOM   1721 N  N   . SER A 1 260 ? -4.453  -43.554 -37.895 1.00 43.05  ? 523  SER A N   1 
ATOM   1722 C  CA  . SER A 1 260 ? -3.251  -44.388 -38.163 1.00 42.75  ? 523  SER A CA  1 
ATOM   1723 C  C   . SER A 1 260 ? -3.026  -44.499 -39.672 1.00 44.11  ? 523  SER A C   1 
ATOM   1724 O  O   . SER A 1 260 ? -1.902  -44.472 -40.061 1.00 41.45  ? 523  SER A O   1 
ATOM   1725 C  CB  . SER A 1 260 ? -3.328  -45.763 -37.528 1.00 43.58  ? 523  SER A CB  1 
ATOM   1726 O  OG  . SER A 1 260 ? -3.942  -46.706 -38.407 1.00 45.05  ? 523  SER A OG  1 
ATOM   1727 N  N   . LYS A 1 261 ? -4.074  -44.534 -40.481 1.00 42.85  ? 524  LYS A N   1 
ATOM   1728 C  CA  . LYS A 1 261 ? -4.003  -44.778 -41.948 1.00 45.90  ? 524  LYS A CA  1 
ATOM   1729 C  C   . LYS A 1 261 ? -3.389  -43.577 -42.675 1.00 44.21  ? 524  LYS A C   1 
ATOM   1730 O  O   . LYS A 1 261 ? -2.993  -43.766 -43.832 1.00 48.51  ? 524  LYS A O   1 
ATOM   1731 C  CB  . LYS A 1 261 ? -5.399  -45.057 -42.517 1.00 45.13  ? 524  LYS A CB  1 
ATOM   1732 C  CG  . LYS A 1 261 ? -5.815  -46.507 -42.428 1.00 54.34  ? 524  LYS A CG  1 
ATOM   1733 C  CD  . LYS A 1 261 ? -7.292  -46.685 -42.702 1.00 61.44  ? 524  LYS A CD  1 
ATOM   1734 C  CE  . LYS A 1 261 ? -7.794  -47.981 -42.126 1.00 68.56  ? 524  LYS A CE  1 
ATOM   1735 N  NZ  . LYS A 1 261 ? -8.779  -48.599 -43.038 1.00 90.07  ? 524  LYS A NZ  1 
ATOM   1736 N  N   . LYS A 1 262 ? -3.384  -42.399 -42.048 1.00 43.51  ? 525  LYS A N   1 
ATOM   1737 C  CA  . LYS A 1 262 ? -2.776  -41.159 -42.601 1.00 48.78  ? 525  LYS A CA  1 
ATOM   1738 C  C   . LYS A 1 262 ? -1.258  -41.338 -42.683 1.00 49.81  ? 525  LYS A C   1 
ATOM   1739 O  O   . LYS A 1 262 ? -0.695  -42.031 -41.814 1.00 52.19  ? 525  LYS A O   1 
ATOM   1740 C  CB  . LYS A 1 262 ? -3.140  -39.936 -41.752 1.00 45.77  ? 525  LYS A CB  1 
ATOM   1741 C  CG  . LYS A 1 262 ? -4.642  -39.668 -41.698 1.00 50.85  ? 525  LYS A CG  1 
ATOM   1742 C  CD  . LYS A 1 262 ? -4.997  -38.231 -41.733 1.00 55.57  ? 525  LYS A CD  1 
ATOM   1743 C  CE  . LYS A 1 262 ? -6.358  -37.971 -42.336 1.00 67.77  ? 525  LYS A CE  1 
ATOM   1744 N  NZ  . LYS A 1 262 ? -6.400  -36.630 -42.970 1.00 73.39  ? 525  LYS A NZ  1 
ATOM   1745 N  N   . GLU A 1 263 ? -0.630  -40.715 -43.678 1.00 49.38  ? 526  GLU A N   1 
ATOM   1746 C  CA  . GLU A 1 263 ? 0.846   -40.648 -43.775 1.00 49.77  ? 526  GLU A CA  1 
ATOM   1747 C  C   . GLU A 1 263 ? 1.298   -39.723 -42.650 1.00 46.41  ? 526  GLU A C   1 
ATOM   1748 O  O   . GLU A 1 263 ? 0.632   -38.704 -42.465 1.00 46.37  ? 526  GLU A O   1 
ATOM   1749 C  CB  . GLU A 1 263 ? 1.308   -40.139 -45.148 1.00 60.17  ? 526  GLU A CB  1 
ATOM   1750 C  CG  . GLU A 1 263 ? 1.011   -41.076 -46.329 1.00 69.30  ? 526  GLU A CG  1 
ATOM   1751 C  CD  . GLU A 1 263 ? 1.591   -42.493 -46.290 1.00 75.10  ? 526  GLU A CD  1 
ATOM   1752 O  OE1 . GLU A 1 263 ? 2.617   -42.713 -45.603 1.00 80.05  ? 526  GLU A OE1 1 
ATOM   1753 O  OE2 . GLU A 1 263 ? 1.012   -43.389 -46.952 1.00 81.03  ? 526  GLU A OE2 1 
ATOM   1754 N  N   . GLY A 1 264 ? 2.349   -40.084 -41.912 1.00 42.98  ? 527  GLY A N   1 
ATOM   1755 C  CA  . GLY A 1 264 ? 3.031   -39.150 -41.003 1.00 43.88  ? 527  GLY A CA  1 
ATOM   1756 C  C   . GLY A 1 264 ? 3.904   -39.837 -39.974 1.00 46.73  ? 527  GLY A C   1 
ATOM   1757 O  O   . GLY A 1 264 ? 4.376   -40.977 -40.196 1.00 45.73  ? 527  GLY A O   1 
ATOM   1758 N  N   . GLY A 1 265 ? 4.125   -39.166 -38.847 1.00 48.34  ? 528  GLY A N   1 
ATOM   1759 C  CA  . GLY A 1 265 ? 5.038   -39.678 -37.809 1.00 49.02  ? 528  GLY A CA  1 
ATOM   1760 C  C   . GLY A 1 265 ? 4.329   -40.558 -36.797 1.00 51.25  ? 528  GLY A C   1 
ATOM   1761 O  O   . GLY A 1 265 ? 3.282   -41.161 -37.129 1.00 49.40  ? 528  GLY A O   1 
ATOM   1762 N  N   . ALA A 1 266 ? 4.894   -40.646 -35.601 1.00 45.48  ? 529  ALA A N   1 
ATOM   1763 C  CA  . ALA A 1 266 ? 4.344   -41.445 -34.495 1.00 45.42  ? 529  ALA A CA  1 
ATOM   1764 C  C   . ALA A 1 266 ? 2.980   -40.857 -34.127 1.00 41.56  ? 529  ALA A C   1 
ATOM   1765 O  O   . ALA A 1 266 ? 2.651   -39.722 -34.577 1.00 38.99  ? 529  ALA A O   1 
ATOM   1766 C  CB  . ALA A 1 266 ? 5.308   -41.425 -33.334 1.00 41.17  ? 529  ALA A CB  1 
ATOM   1767 N  N   . MET A 1 267 ? 2.231   -41.571 -33.296 1.00 37.17  ? 530  MET A N   1 
ATOM   1768 C  CA  . MET A 1 267 ? 1.013   -41.032 -32.664 1.00 39.30  ? 530  MET A CA  1 
ATOM   1769 C  C   . MET A 1 267 ? 1.405   -40.518 -31.272 1.00 36.18  ? 530  MET A C   1 
ATOM   1770 O  O   . MET A 1 267 ? 1.989   -41.275 -30.484 1.00 39.54  ? 530  MET A O   1 
ATOM   1771 C  CB  . MET A 1 267 ? -0.089  -42.099 -32.623 1.00 43.87  ? 530  MET A CB  1 
ATOM   1772 C  CG  . MET A 1 267 ? -0.603  -42.503 -34.013 1.00 45.73  ? 530  MET A CG  1 
ATOM   1773 S  SD  . MET A 1 267 ? -1.977  -43.700 -34.001 1.00 49.23  ? 530  MET A SD  1 
ATOM   1774 C  CE  . MET A 1 267 ? -3.415  -42.659 -33.803 1.00 60.00  ? 530  MET A CE  1 
ATOM   1775 N  N   . TYR A 1 268 ? 1.086   -39.266 -30.987 1.00 34.30  ? 531  TYR A N   1 
ATOM   1776 C  CA  . TYR A 1 268 ? 1.385   -38.577 -29.721 1.00 33.58  ? 531  TYR A CA  1 
ATOM   1777 C  C   . TYR A 1 268 ? 0.108   -38.446 -28.902 1.00 33.45  ? 531  TYR A C   1 
ATOM   1778 O  O   . TYR A 1 268 ? -0.925  -38.116 -29.437 1.00 38.16  ? 531  TYR A O   1 
ATOM   1779 C  CB  . TYR A 1 268 ? 2.070   -37.241 -30.003 1.00 36.08  ? 531  TYR A CB  1 
ATOM   1780 C  CG  . TYR A 1 268 ? 3.382   -37.418 -30.724 1.00 37.76  ? 531  TYR A CG  1 
ATOM   1781 C  CD1 . TYR A 1 268 ? 3.418   -37.590 -32.092 1.00 38.32  ? 531  TYR A CD1 1 
ATOM   1782 C  CD2 . TYR A 1 268 ? 4.574   -37.515 -30.026 1.00 37.37  ? 531  TYR A CD2 1 
ATOM   1783 C  CE1 . TYR A 1 268 ? 4.617   -37.788 -32.749 1.00 38.94  ? 531  TYR A CE1 1 
ATOM   1784 C  CE2 . TYR A 1 268 ? 5.772   -37.737 -30.664 1.00 38.12  ? 531  TYR A CE2 1 
ATOM   1785 C  CZ  . TYR A 1 268 ? 5.792   -37.879 -32.036 1.00 43.65  ? 531  TYR A CZ  1 
ATOM   1786 O  OH  . TYR A 1 268 ? 6.953   -38.129 -32.707 1.00 39.66  ? 531  TYR A OH  1 
ATOM   1787 N  N   . ALA A 1 269 ? 0.227   -38.690 -27.606 1.00 35.89  ? 532  ALA A N   1 
ATOM   1788 C  CA  . ALA A 1 269 ? -0.874  -38.692 -26.654 1.00 36.68  ? 532  ALA A CA  1 
ATOM   1789 C  C   . ALA A 1 269 ? -0.347  -38.146 -25.343 1.00 34.66  ? 532  ALA A C   1 
ATOM   1790 O  O   . ALA A 1 269 ? -0.392  -38.841 -24.352 1.00 38.76  ? 532  ALA A O   1 
ATOM   1791 C  CB  . ALA A 1 269 ? -1.436  -40.069 -26.546 1.00 40.88  ? 532  ALA A CB  1 
ATOM   1792 N  N   . ASP A 1 270 ? 0.033   -36.884 -25.346 1.00 31.95  ? 533  ASP A N   1 
ATOM   1793 C  CA  . ASP A 1 270 ? 0.575   -36.180 -24.161 1.00 36.00  ? 533  ASP A CA  1 
ATOM   1794 C  C   . ASP A 1 270 ? -0.597  -35.675 -23.344 1.00 42.31  ? 533  ASP A C   1 
ATOM   1795 O  O   . ASP A 1 270 ? -1.349  -34.858 -23.858 1.00 45.08  ? 533  ASP A O   1 
ATOM   1796 C  CB  . ASP A 1 270 ? 1.514   -35.032 -24.563 1.00 34.84  ? 533  ASP A CB  1 
ATOM   1797 C  CG  . ASP A 1 270 ? 2.752   -35.527 -25.297 1.00 38.80  ? 533  ASP A CG  1 
ATOM   1798 O  OD1 . ASP A 1 270 ? 3.064   -36.735 -25.150 1.00 42.07  ? 533  ASP A OD1 1 
ATOM   1799 O  OD2 . ASP A 1 270 ? 3.349   -34.744 -26.057 1.00 38.29  ? 533  ASP A OD2 1 
ATOM   1800 N  N   . ASP A 1 271 ? -0.733  -36.180 -22.129 1.00 44.53  ? 534  ASP A N   1 
ATOM   1801 C  CA  . ASP A 1 271 ? -1.636  -35.627 -21.096 1.00 45.86  ? 534  ASP A CA  1 
ATOM   1802 C  C   . ASP A 1 271 ? -1.085  -34.304 -20.588 1.00 43.76  ? 534  ASP A C   1 
ATOM   1803 O  O   . ASP A 1 271 ? 0.123   -34.197 -20.383 1.00 47.13  ? 534  ASP A O   1 
ATOM   1804 C  CB  . ASP A 1 271 ? -1.721  -36.541 -19.878 1.00 49.12  ? 534  ASP A CB  1 
ATOM   1805 C  CG  . ASP A 1 271 ? -2.651  -37.700 -20.119 1.00 57.07  ? 534  ASP A CG  1 
ATOM   1806 O  OD1 . ASP A 1 271 ? -3.204  -37.744 -21.232 1.00 62.39  ? 534  ASP A OD1 1 
ATOM   1807 O  OD2 . ASP A 1 271 ? -2.873  -38.497 -19.176 1.00 63.90  ? 534  ASP A OD2 1 
ATOM   1808 N  N   . THR A 1 272 ? -1.966  -33.325 -20.369 0.26 44.43  ? 535  THR A N   1 
ATOM   1809 C  CA  . THR A 1 272 ? -1.644  -32.037 -19.700 0.26 45.11  ? 535  THR A CA  1 
ATOM   1810 C  C   . THR A 1 272 ? -1.791  -32.229 -18.190 0.26 46.56  ? 535  THR A C   1 
ATOM   1811 O  O   . THR A 1 272 ? -2.688  -32.986 -17.780 0.26 49.59  ? 535  THR A O   1 
ATOM   1812 C  CB  . THR A 1 272 ? -2.516  -30.892 -20.228 0.26 44.75  ? 535  THR A CB  1 
ATOM   1813 O  OG1 . THR A 1 272 ? -2.287  -30.795 -21.634 0.26 45.67  ? 535  THR A OG1 1 
ATOM   1814 C  CG2 . THR A 1 272 ? -2.216  -29.560 -19.574 0.26 44.87  ? 535  THR A CG2 1 
ATOM   1815 N  N   . ALA A 1 273 ? -0.932  -31.570 -17.409 0.26 49.04  ? 536  ALA A N   1 
ATOM   1816 C  CA  . ALA A 1 273 ? -0.886  -31.637 -15.929 0.26 50.72  ? 536  ALA A CA  1 
ATOM   1817 C  C   . ALA A 1 273 ? -1.870  -30.619 -15.336 0.26 50.93  ? 536  ALA A C   1 
ATOM   1818 O  O   . ALA A 1 273 ? -1.488  -29.441 -15.183 0.26 54.18  ? 536  ALA A O   1 
ATOM   1819 C  CB  . ALA A 1 273 ? 0.531   -31.396 -15.460 0.26 51.11  ? 536  ALA A CB  1 
ATOM   1820 N  N   . GLY A 1 274 ? -3.092  -31.066 -15.024 0.26 51.00  ? 537  GLY A N   1 
ATOM   1821 C  CA  . GLY A 1 274 ? -4.166  -30.246 -14.425 0.26 49.73  ? 537  GLY A CA  1 
ATOM   1822 C  C   . GLY A 1 274 ? -4.753  -29.257 -15.419 0.26 48.76  ? 537  GLY A C   1 
ATOM   1823 O  O   . GLY A 1 274 ? -4.792  -28.055 -15.094 0.26 47.52  ? 537  GLY A O   1 
ATOM   1824 N  N   . TRP A 1 275 ? -5.223  -29.749 -16.572 0.26 46.70  ? 538  TRP A N   1 
ATOM   1825 C  CA  . TRP A 1 275 ? -5.728  -28.933 -17.712 0.26 45.74  ? 538  TRP A CA  1 
ATOM   1826 C  C   . TRP A 1 275 ? -6.596  -27.771 -17.212 0.26 45.27  ? 538  TRP A C   1 
ATOM   1827 O  O   . TRP A 1 275 ? -6.352  -26.635 -17.654 0.26 44.33  ? 538  TRP A O   1 
ATOM   1828 C  CB  . TRP A 1 275 ? -6.499  -29.800 -18.715 0.26 44.84  ? 538  TRP A CB  1 
ATOM   1829 C  CG  . TRP A 1 275 ? -7.129  -29.005 -19.818 0.26 44.17  ? 538  TRP A CG  1 
ATOM   1830 C  CD1 . TRP A 1 275 ? -8.364  -28.428 -19.809 0.26 43.86  ? 538  TRP A CD1 1 
ATOM   1831 C  CD2 . TRP A 1 275 ? -6.550  -28.689 -21.097 0.26 44.07  ? 538  TRP A CD2 1 
ATOM   1832 N  NE1 . TRP A 1 275 ? -8.593  -27.777 -20.991 0.26 44.27  ? 538  TRP A NE1 1 
ATOM   1833 C  CE2 . TRP A 1 275 ? -7.500  -27.918 -21.800 0.26 44.51  ? 538  TRP A CE2 1 
ATOM   1834 C  CE3 . TRP A 1 275 ? -5.331  -28.979 -21.717 0.26 43.73  ? 538  TRP A CE3 1 
ATOM   1835 C  CZ2 . TRP A 1 275 ? -7.266  -27.435 -23.087 0.26 44.79  ? 538  TRP A CZ2 1 
ATOM   1836 C  CZ3 . TRP A 1 275 ? -5.100  -28.502 -22.989 0.26 44.70  ? 538  TRP A CZ3 1 
ATOM   1837 C  CH2 . TRP A 1 275 ? -6.056  -27.743 -23.664 0.26 44.72  ? 538  TRP A CH2 1 
ATOM   1838 N  N   . ASP A 1 276 ? -7.569  -28.048 -16.338 0.26 45.89  ? 539  ASP A N   1 
ATOM   1839 C  CA  . ASP A 1 276 ? -8.564  -27.053 -15.850 0.26 47.54  ? 539  ASP A CA  1 
ATOM   1840 C  C   . ASP A 1 276 ? -7.846  -25.907 -15.121 0.26 49.35  ? 539  ASP A C   1 
ATOM   1841 O  O   . ASP A 1 276 ? -8.293  -24.751 -15.272 0.26 48.13  ? 539  ASP A O   1 
ATOM   1842 C  CB  . ASP A 1 276 ? -9.638  -27.703 -14.970 0.26 47.73  ? 539  ASP A CB  1 
ATOM   1843 C  CG  . ASP A 1 276 ? -10.742 -28.394 -15.758 0.26 48.44  ? 539  ASP A CG  1 
ATOM   1844 O  OD1 . ASP A 1 276 ? -10.418 -29.085 -16.746 0.26 47.25  ? 539  ASP A OD1 1 
ATOM   1845 O  OD2 . ASP A 1 276 ? -11.923 -28.232 -15.381 0.26 48.33  ? 539  ASP A OD2 1 
ATOM   1846 N  N   . THR A 1 277 ? -6.767  -26.200 -14.382 0.26 50.32  ? 540  THR A N   1 
ATOM   1847 C  CA  . THR A 1 277 ? -5.992  -25.192 -13.607 0.26 50.29  ? 540  THR A CA  1 
ATOM   1848 C  C   . THR A 1 277 ? -5.092  -24.373 -14.546 0.26 49.33  ? 540  THR A C   1 
ATOM   1849 O  O   . THR A 1 277 ? -4.595  -23.327 -14.093 0.26 49.43  ? 540  THR A O   1 
ATOM   1850 C  CB  . THR A 1 277 ? -5.207  -25.854 -12.466 0.26 51.51  ? 540  THR A CB  1 
ATOM   1851 O  OG1 . THR A 1 277 ? -4.255  -26.777 -12.995 0.26 54.19  ? 540  THR A OG1 1 
ATOM   1852 C  CG2 . THR A 1 277 ? -6.108  -26.584 -11.495 0.26 51.86  ? 540  THR A CG2 1 
ATOM   1853 N  N   . ARG A 1 278 ? -4.910  -24.813 -15.799 0.26 49.47  ? 541  ARG A N   1 
ATOM   1854 C  CA  . ARG A 1 278 ? -3.954  -24.233 -16.785 0.26 48.37  ? 541  ARG A CA  1 
ATOM   1855 C  C   . ARG A 1 278 ? -4.689  -23.384 -17.831 0.26 47.32  ? 541  ARG A C   1 
ATOM   1856 O  O   . ARG A 1 278 ? -4.026  -22.954 -18.794 0.26 47.73  ? 541  ARG A O   1 
ATOM   1857 C  CB  . ARG A 1 278 ? -3.188  -25.345 -17.508 0.26 50.24  ? 541  ARG A CB  1 
ATOM   1858 C  CG  . ARG A 1 278 ? -2.504  -26.345 -16.588 0.26 53.46  ? 541  ARG A CG  1 
ATOM   1859 C  CD  . ARG A 1 278 ? -1.115  -25.919 -16.159 0.26 55.80  ? 541  ARG A CD  1 
ATOM   1860 N  NE  . ARG A 1 278 ? -0.539  -26.850 -15.196 0.26 58.94  ? 541  ARG A NE  1 
ATOM   1861 C  CZ  . ARG A 1 278 ? 0.712   -26.799 -14.744 0.26 58.51  ? 541  ARG A CZ  1 
ATOM   1862 N  NH1 . ARG A 1 278 ? 1.541   -25.862 -15.175 0.26 58.21  ? 541  ARG A NH1 1 
ATOM   1863 N  NH2 . ARG A 1 278 ? 1.130   -27.692 -13.862 0.26 58.48  ? 541  ARG A NH2 1 
ATOM   1864 N  N   . ILE A 1 279 ? -6.000  -23.172 -17.674 0.26 47.29  ? 542  ILE A N   1 
ATOM   1865 C  CA  . ILE A 1 279 ? -6.824  -22.336 -18.600 0.26 47.45  ? 542  ILE A CA  1 
ATOM   1866 C  C   . ILE A 1 279 ? -6.574  -20.859 -18.268 0.26 46.29  ? 542  ILE A C   1 
ATOM   1867 O  O   . ILE A 1 279 ? -6.880  -20.443 -17.135 0.26 45.94  ? 542  ILE A O   1 
ATOM   1868 C  CB  . ILE A 1 279 ? -8.317  -22.724 -18.516 0.26 48.22  ? 542  ILE A CB  1 
ATOM   1869 C  CG1 . ILE A 1 279 ? -8.565  -24.131 -19.070 0.26 47.66  ? 542  ILE A CG1 1 
ATOM   1870 C  CG2 . ILE A 1 279 ? -9.200  -21.693 -19.209 0.26 48.21  ? 542  ILE A CG2 1 
ATOM   1871 C  CD1 . ILE A 1 279 ? -8.247  -24.285 -20.542 0.26 47.49  ? 542  ILE A CD1 1 
ATOM   1872 N  N   . THR A 1 280 ? -6.028  -20.106 -19.227 1.00 46.07  ? 543  THR A N   1 
ATOM   1873 C  CA  . THR A 1 280 ? -5.634  -18.689 -19.042 1.00 48.33  ? 543  THR A CA  1 
ATOM   1874 C  C   . THR A 1 280 ? -6.873  -17.838 -19.295 1.00 57.54  ? 543  THR A C   1 
ATOM   1875 O  O   . THR A 1 280 ? -7.821  -18.369 -19.905 1.00 51.45  ? 543  THR A O   1 
ATOM   1876 C  CB  . THR A 1 280 ? -4.466  -18.383 -19.977 1.00 46.49  ? 543  THR A CB  1 
ATOM   1877 O  OG1 . THR A 1 280 ? -4.906  -18.545 -21.323 1.00 44.29  ? 543  THR A OG1 1 
ATOM   1878 C  CG2 . THR A 1 280 ? -3.307  -19.322 -19.744 1.00 51.04  ? 543  THR A CG2 1 
ATOM   1879 N  N   . LEU A 1 281 ? -6.884  -16.593 -18.822 1.00 60.94  ? 544  LEU A N   1 
ATOM   1880 C  CA  . LEU A 1 281 ? -7.928  -15.617 -19.225 1.00 60.38  ? 544  LEU A CA  1 
ATOM   1881 C  C   . LEU A 1 281 ? -7.860  -15.427 -20.749 1.00 52.43  ? 544  LEU A C   1 
ATOM   1882 O  O   . LEU A 1 281 ? -8.899  -15.224 -21.350 1.00 51.83  ? 544  LEU A O   1 
ATOM   1883 C  CB  . LEU A 1 281 ? -7.732  -14.299 -18.474 1.00 74.35  ? 544  LEU A CB  1 
ATOM   1884 C  CG  . LEU A 1 281 ? -8.622  -13.148 -18.948 1.00 81.48  ? 544  LEU A CG  1 
ATOM   1885 C  CD1 . LEU A 1 281 ? -10.109 -13.522 -18.931 1.00 69.69  ? 544  LEU A CD1 1 
ATOM   1886 C  CD2 . LEU A 1 281 ? -8.363  -11.906 -18.107 1.00 87.58  ? 544  LEU A CD2 1 
ATOM   1887 N  N   . GLU A 1 282 ? -6.698  -15.592 -21.381 1.00 56.05  ? 545  GLU A N   1 
ATOM   1888 C  CA  . GLU A 1 282 ? -6.594  -15.508 -22.867 1.00 54.27  ? 545  GLU A CA  1 
ATOM   1889 C  C   . GLU A 1 282 ? -7.369  -16.665 -23.530 1.00 49.74  ? 545  GLU A C   1 
ATOM   1890 O  O   . GLU A 1 282 ? -7.996  -16.461 -24.608 1.00 47.91  ? 545  GLU A O   1 
ATOM   1891 C  CB  . GLU A 1 282 ? -5.126  -15.452 -23.291 1.00 59.38  ? 545  GLU A CB  1 
ATOM   1892 C  CG  . GLU A 1 282 ? -4.947  -14.748 -24.621 1.00 66.21  ? 545  GLU A CG  1 
ATOM   1893 C  CD  . GLU A 1 282 ? -5.080  -13.236 -24.567 1.00 68.75  ? 545  GLU A CD  1 
ATOM   1894 O  OE1 . GLU A 1 282 ? -4.876  -12.652 -23.454 1.00 69.60  ? 545  GLU A OE1 1 
ATOM   1895 O  OE2 . GLU A 1 282 ? -5.377  -12.649 -25.635 1.00 75.48  ? 545  GLU A OE2 1 
ATOM   1896 N  N   . ASP A 1 283 ? -7.348  -17.846 -22.918 1.00 49.50  ? 546  ASP A N   1 
ATOM   1897 C  CA  . ASP A 1 283 ? -8.137  -19.026 -23.383 1.00 49.51  ? 546  ASP A CA  1 
ATOM   1898 C  C   . ASP A 1 283 ? -9.637  -18.697 -23.243 1.00 48.30  ? 546  ASP A C   1 
ATOM   1899 O  O   . ASP A 1 283 ? -10.407 -18.884 -24.241 1.00 44.86  ? 546  ASP A O   1 
ATOM   1900 C  CB  . ASP A 1 283 ? -7.811  -20.292 -22.572 1.00 43.88  ? 546  ASP A CB  1 
ATOM   1901 C  CG  . ASP A 1 283 ? -6.450  -20.914 -22.851 1.00 45.99  ? 546  ASP A CG  1 
ATOM   1902 O  OD1 . ASP A 1 283 ? -5.969  -20.791 -23.988 1.00 39.17  ? 546  ASP A OD1 1 
ATOM   1903 O  OD2 . ASP A 1 283 ? -5.879  -21.519 -21.903 1.00 47.86  ? 546  ASP A OD2 1 
ATOM   1904 N  N   . LEU A 1 284 ? -10.035 -18.215 -22.055 1.00 41.12  ? 547  LEU A N   1 
ATOM   1905 C  CA  . LEU A 1 284 ? -11.444 -17.829 -21.749 1.00 42.47  ? 547  LEU A CA  1 
ATOM   1906 C  C   . LEU A 1 284 ? -11.968 -16.781 -22.761 1.00 45.49  ? 547  LEU A C   1 
ATOM   1907 O  O   . LEU A 1 284 ? -13.142 -16.883 -23.161 1.00 45.86  ? 547  LEU A O   1 
ATOM   1908 C  CB  . LEU A 1 284 ? -11.509 -17.352 -20.297 1.00 39.03  ? 547  LEU A CB  1 
ATOM   1909 C  CG  . LEU A 1 284 ? -11.296 -18.459 -19.267 1.00 44.64  ? 547  LEU A CG  1 
ATOM   1910 C  CD1 . LEU A 1 284 ? -11.171 -17.901 -17.858 1.00 49.09  ? 547  LEU A CD1 1 
ATOM   1911 C  CD2 . LEU A 1 284 ? -12.408 -19.515 -19.300 1.00 44.45  ? 547  LEU A CD2 1 
ATOM   1912 N  N   . LYS A 1 285 ? -11.121 -15.846 -23.205 1.00 49.26  ? 548  LYS A N   1 
ATOM   1913 C  CA  . LYS A 1 285 ? -11.457 -14.778 -24.180 1.00 51.28  ? 548  LYS A CA  1 
ATOM   1914 C  C   . LYS A 1 285 ? -11.575 -15.365 -25.587 1.00 49.02  ? 548  LYS A C   1 
ATOM   1915 O  O   . LYS A 1 285 ? -12.459 -14.944 -26.332 1.00 51.35  ? 548  LYS A O   1 
ATOM   1916 C  CB  . LYS A 1 285 ? -10.411 -13.658 -24.154 1.00 50.47  ? 548  LYS A CB  1 
ATOM   1917 C  CG  . LYS A 1 285 ? -10.555 -12.686 -22.997 1.00 63.70  ? 548  LYS A CG  1 
ATOM   1918 C  CD  . LYS A 1 285 ? -9.697  -11.437 -23.140 1.00 78.60  ? 548  LYS A CD  1 
ATOM   1919 C  CE  . LYS A 1 285 ? -10.134 -10.302 -22.233 1.00 89.92  ? 548  LYS A CE  1 
ATOM   1920 N  NZ  . LYS A 1 285 ? -8.971  -9.566  -21.672 1.00 102.67 ? 548  LYS A NZ  1 
ATOM   1921 N  N   . ASN A 1 286 ? -10.694 -16.272 -25.965 1.00 44.03  ? 549  ASN A N   1 
ATOM   1922 C  CA  . ASN A 1 286 ? -10.788 -16.955 -27.279 1.00 44.89  ? 549  ASN A CA  1 
ATOM   1923 C  C   . ASN A 1 286 ? -12.055 -17.829 -27.343 1.00 43.24  ? 549  ASN A C   1 
ATOM   1924 O  O   . ASN A 1 286 ? -12.618 -17.944 -28.439 1.00 39.45  ? 549  ASN A O   1 
ATOM   1925 C  CB  . ASN A 1 286 ? -9.503  -17.732 -27.532 1.00 50.54  ? 549  ASN A CB  1 
ATOM   1926 C  CG  . ASN A 1 286 ? -8.340  -16.792 -27.789 1.00 54.51  ? 549  ASN A CG  1 
ATOM   1927 O  OD1 . ASN A 1 286 ? -8.506  -15.746 -28.409 1.00 48.39  ? 549  ASN A OD1 1 
ATOM   1928 N  ND2 . ASN A 1 286 ? -7.156  -17.161 -27.339 1.00 62.47  ? 549  ASN A ND2 1 
ATOM   1929 N  N   . GLU A 1 287 ? -12.443 -18.445 -26.221 1.00 40.17  ? 550  GLU A N   1 
ATOM   1930 C  CA  . GLU A 1 287 ? -13.684 -19.258 -26.066 1.00 46.05  ? 550  GLU A CA  1 
ATOM   1931 C  C   . GLU A 1 287 ? -14.934 -18.366 -26.252 1.00 44.35  ? 550  GLU A C   1 
ATOM   1932 O  O   . GLU A 1 287 ? -15.872 -18.795 -26.906 1.00 46.17  ? 550  GLU A O   1 
ATOM   1933 C  CB  . GLU A 1 287 ? -13.676 -19.972 -24.706 1.00 42.34  ? 550  GLU A CB  1 
ATOM   1934 C  CG  . GLU A 1 287 ? -12.700 -21.123 -24.664 1.00 45.48  ? 550  GLU A CG  1 
ATOM   1935 C  CD  . GLU A 1 287 ? -12.320 -21.685 -23.299 1.00 48.82  ? 550  GLU A CD  1 
ATOM   1936 O  OE1 . GLU A 1 287 ? -12.992 -21.372 -22.295 1.00 47.46  ? 550  GLU A OE1 1 
ATOM   1937 O  OE2 . GLU A 1 287 ? -11.382 -22.517 -23.244 1.00 48.14  ? 550  GLU A OE2 1 
ATOM   1938 N  N   . GLU A 1 288 ? -14.902 -17.153 -25.687 0.40 45.17  ? 551  GLU A N   1 
ATOM   1939 C  CA  . GLU A 1 288 ? -15.990 -16.136 -25.753 0.40 47.00  ? 551  GLU A CA  1 
ATOM   1940 C  C   . GLU A 1 288 ? -16.289 -15.770 -27.212 0.40 46.45  ? 551  GLU A C   1 
ATOM   1941 O  O   . GLU A 1 288 ? -17.438 -15.387 -27.485 0.40 50.21  ? 551  GLU A O   1 
ATOM   1942 C  CB  . GLU A 1 288 ? -15.605 -14.880 -24.964 0.40 49.11  ? 551  GLU A CB  1 
ATOM   1943 C  CG  . GLU A 1 288 ? -16.754 -13.906 -24.743 0.40 50.73  ? 551  GLU A CG  1 
ATOM   1944 C  CD  . GLU A 1 288 ? -16.970 -12.841 -25.813 0.40 51.33  ? 551  GLU A CD  1 
ATOM   1945 O  OE1 . GLU A 1 288 ? -16.096 -12.676 -26.693 0.40 50.04  ? 551  GLU A OE1 1 
ATOM   1946 O  OE2 . GLU A 1 288 ? -18.020 -12.171 -25.760 0.40 54.13  ? 551  GLU A OE2 1 
ATOM   1947 N  N   . MET A 1 289 ? -15.309 -15.898 -28.112 1.00 44.64  ? 552  MET A N   1 
ATOM   1948 C  CA  . MET A 1 289 ? -15.486 -15.507 -29.530 1.00 44.42  ? 552  MET A CA  1 
ATOM   1949 C  C   . MET A 1 289 ? -16.593 -16.314 -30.183 1.00 44.99  ? 552  MET A C   1 
ATOM   1950 O  O   . MET A 1 289 ? -16.996 -15.922 -31.309 1.00 50.24  ? 552  MET A O   1 
ATOM   1951 C  CB  . MET A 1 289 ? -14.197 -15.630 -30.348 1.00 45.76  ? 552  MET A CB  1 
ATOM   1952 C  CG  . MET A 1 289 ? -13.099 -14.713 -29.781 1.00 53.79  ? 552  MET A CG  1 
ATOM   1953 S  SD  . MET A 1 289 ? -11.837 -14.205 -30.967 1.00 58.98  ? 552  MET A SD  1 
ATOM   1954 C  CE  . MET A 1 289 ? -11.607 -15.661 -31.966 1.00 51.08  ? 552  MET A CE  1 
ATOM   1955 N  N   . VAL A 1 290 ? -17.108 -17.376 -29.552 1.00 44.43  ? 553  VAL A N   1 
ATOM   1956 C  CA  . VAL A 1 290 ? -18.305 -18.058 -30.135 1.00 40.85  ? 553  VAL A CA  1 
ATOM   1957 C  C   . VAL A 1 290 ? -19.481 -17.057 -30.200 1.00 41.27  ? 553  VAL A C   1 
ATOM   1958 O  O   . VAL A 1 290 ? -20.297 -17.178 -31.149 1.00 40.89  ? 553  VAL A O   1 
ATOM   1959 C  CB  . VAL A 1 290 ? -18.672 -19.365 -29.418 1.00 37.86  ? 553  VAL A CB  1 
ATOM   1960 C  CG1 . VAL A 1 290 ? -19.102 -19.183 -27.962 1.00 35.29  ? 553  VAL A CG1 1 
ATOM   1961 C  CG2 . VAL A 1 290 ? -19.719 -20.123 -30.225 1.00 40.06  ? 553  VAL A CG2 1 
ATOM   1962 N  N   . THR A 1 291 ? -19.546 -16.076 -29.292 1.00 39.13  ? 554  THR A N   1 
ATOM   1963 C  CA  . THR A 1 291 ? -20.624 -15.040 -29.294 1.00 44.92  ? 554  THR A CA  1 
ATOM   1964 C  C   . THR A 1 291 ? -20.604 -14.233 -30.603 1.00 44.77  ? 554  THR A C   1 
ATOM   1965 O  O   . THR A 1 291 ? -21.688 -13.757 -31.021 1.00 45.76  ? 554  THR A O   1 
ATOM   1966 C  CB  . THR A 1 291 ? -20.560 -14.067 -28.116 1.00 40.48  ? 554  THR A CB  1 
ATOM   1967 O  OG1 . THR A 1 291 ? -19.258 -13.476 -28.102 1.00 40.41  ? 554  THR A OG1 1 
ATOM   1968 C  CG2 . THR A 1 291 ? -20.816 -14.722 -26.779 1.00 40.62  ? 554  THR A CG2 1 
ATOM   1969 N  N   . ASN A 1 292 ? -19.486 -14.150 -31.309 1.00 44.69  ? 555  ASN A N   1 
ATOM   1970 C  CA  . ASN A 1 292 ? -19.470 -13.439 -32.625 1.00 47.89  ? 555  ASN A CA  1 
ATOM   1971 C  C   . ASN A 1 292 ? -20.318 -14.160 -33.691 1.00 51.22  ? 555  ASN A C   1 
ATOM   1972 O  O   . ASN A 1 292 ? -20.482 -13.579 -34.773 1.00 53.42  ? 555  ASN A O   1 
ATOM   1973 C  CB  . ASN A 1 292 ? -18.070 -13.272 -33.205 1.00 48.00  ? 555  ASN A CB  1 
ATOM   1974 C  CG  . ASN A 1 292 ? -17.121 -12.591 -32.247 1.00 52.01  ? 555  ASN A CG  1 
ATOM   1975 O  OD1 . ASN A 1 292 ? -17.528 -12.041 -31.233 1.00 65.83  ? 555  ASN A OD1 1 
ATOM   1976 N  ND2 . ASN A 1 292 ? -15.842 -12.653 -32.547 1.00 60.62  ? 555  ASN A ND2 1 
ATOM   1977 N  N   . HIS A 1 293 ? -20.817 -15.380 -33.463 1.00 43.79  ? 556  HIS A N   1 
ATOM   1978 C  CA  . HIS A 1 293 ? -21.618 -16.119 -34.482 1.00 50.98  ? 556  HIS A CA  1 
ATOM   1979 C  C   . HIS A 1 293 ? -23.114 -16.083 -34.123 1.00 43.22  ? 556  HIS A C   1 
ATOM   1980 O  O   . HIS A 1 293 ? -23.923 -16.725 -34.826 1.00 46.26  ? 556  HIS A O   1 
ATOM   1981 C  CB  . HIS A 1 293 ? -20.999 -17.513 -34.691 1.00 53.41  ? 556  HIS A CB  1 
ATOM   1982 C  CG  . HIS A 1 293 ? -19.573 -17.395 -35.121 1.00 55.82  ? 556  HIS A CG  1 
ATOM   1983 N  ND1 . HIS A 1 293 ? -19.184 -17.559 -36.433 1.00 52.20  ? 556  HIS A ND1 1 
ATOM   1984 C  CD2 . HIS A 1 293 ? -18.463 -17.041 -34.432 1.00 61.19  ? 556  HIS A CD2 1 
ATOM   1985 C  CE1 . HIS A 1 293 ? -17.890 -17.324 -36.538 1.00 53.31  ? 556  HIS A CE1 1 
ATOM   1986 N  NE2 . HIS A 1 293 ? -17.429 -17.006 -35.326 1.00 61.74  ? 556  HIS A NE2 1 
ATOM   1987 N  N   . MET A 1 294 ? -23.435 -15.347 -33.059 1.00 43.77  ? 557  MET A N   1 
ATOM   1988 C  CA  . MET A 1 294 ? -24.743 -15.293 -32.367 1.00 49.28  ? 557  MET A CA  1 
ATOM   1989 C  C   . MET A 1 294 ? -25.442 -13.980 -32.744 1.00 52.99  ? 557  MET A C   1 
ATOM   1990 O  O   . MET A 1 294 ? -24.882 -13.204 -33.532 1.00 52.08  ? 557  MET A O   1 
ATOM   1991 C  CB  . MET A 1 294 ? -24.558 -15.329 -30.844 1.00 50.51  ? 557  MET A CB  1 
ATOM   1992 C  CG  . MET A 1 294 ? -24.158 -16.697 -30.291 1.00 51.51  ? 557  MET A CG  1 
ATOM   1993 S  SD  . MET A 1 294 ? -24.048 -16.627 -28.491 1.00 50.36  ? 557  MET A SD  1 
ATOM   1994 C  CE  . MET A 1 294 ? -23.140 -18.156 -28.245 1.00 58.19  ? 557  MET A CE  1 
ATOM   1995 N  N   . GLU A 1 295 ? -26.623 -13.740 -32.180 1.00 60.10  ? 558  GLU A N   1 
ATOM   1996 C  CA  . GLU A 1 295 ? -27.428 -12.542 -32.503 1.00 63.24  ? 558  GLU A CA  1 
ATOM   1997 C  C   . GLU A 1 295 ? -28.526 -12.322 -31.477 1.00 60.81  ? 558  GLU A C   1 
ATOM   1998 O  O   . GLU A 1 295 ? -28.904 -13.268 -30.750 1.00 67.53  ? 558  GLU A O   1 
ATOM   1999 C  CB  . GLU A 1 295 ? -28.044 -12.691 -33.890 1.00 63.35  ? 558  GLU A CB  1 
ATOM   2000 C  CG  . GLU A 1 295 ? -29.198 -13.657 -33.979 1.00 64.76  ? 558  GLU A CG  1 
ATOM   2001 C  CD  . GLU A 1 295 ? -29.626 -13.961 -35.411 1.00 77.27  ? 558  GLU A CD  1 
ATOM   2002 O  OE1 . GLU A 1 295 ? -29.100 -13.332 -36.363 1.00 81.43  ? 558  GLU A OE1 1 
ATOM   2003 O  OE2 . GLU A 1 295 ? -30.474 -14.849 -35.577 1.00 82.55  ? 558  GLU A OE2 1 
ATOM   2004 N  N   . GLY A 1 296 ? -29.043 -11.101 -31.496 1.00 65.24  ? 559  GLY A N   1 
ATOM   2005 C  CA  . GLY A 1 296 ? -30.167 -10.670 -30.661 1.00 58.02  ? 559  GLY A CA  1 
ATOM   2006 C  C   . GLY A 1 296 ? -29.851 -10.878 -29.196 1.00 52.93  ? 559  GLY A C   1 
ATOM   2007 O  O   . GLY A 1 296 ? -28.717 -10.577 -28.773 1.00 47.84  ? 559  GLY A O   1 
ATOM   2008 N  N   . GLU A 1 297 ? -30.859 -11.379 -28.493 1.00 50.56  ? 560  GLU A N   1 
ATOM   2009 C  CA  . GLU A 1 297 ? -30.895 -11.668 -27.047 1.00 61.41  ? 560  GLU A CA  1 
ATOM   2010 C  C   . GLU A 1 297 ? -29.823 -12.724 -26.723 1.00 58.25  ? 560  GLU A C   1 
ATOM   2011 O  O   . GLU A 1 297 ? -29.158 -12.596 -25.690 1.00 62.57  ? 560  GLU A O   1 
ATOM   2012 C  CB  . GLU A 1 297 ? -32.301 -12.174 -26.709 1.00 62.73  ? 560  GLU A CB  1 
ATOM   2013 C  CG  . GLU A 1 297 ? -32.806 -11.691 -25.364 1.00 78.67  ? 560  GLU A CG  1 
ATOM   2014 C  CD  . GLU A 1 297 ? -34.247 -12.059 -25.062 1.00 84.17  ? 560  GLU A CD  1 
ATOM   2015 O  OE1 . GLU A 1 297 ? -34.639 -13.196 -25.399 1.00 77.31  ? 560  GLU A OE1 1 
ATOM   2016 O  OE2 . GLU A 1 297 ? -34.975 -11.205 -24.491 1.00 94.91  ? 560  GLU A OE2 1 
ATOM   2017 N  N   . HIS A 1 298 ? -29.702 -13.742 -27.573 1.00 54.92  ? 561  HIS A N   1 
ATOM   2018 C  CA  . HIS A 1 298 ? -28.816 -14.913 -27.369 1.00 55.67  ? 561  HIS A CA  1 
ATOM   2019 C  C   . HIS A 1 298 ? -27.410 -14.377 -27.140 1.00 51.16  ? 561  HIS A C   1 
ATOM   2020 O  O   . HIS A 1 298 ? -26.823 -14.645 -26.073 1.00 49.20  ? 561  HIS A O   1 
ATOM   2021 C  CB  . HIS A 1 298 ? -28.892 -15.873 -28.558 1.00 54.94  ? 561  HIS A CB  1 
ATOM   2022 C  CG  . HIS A 1 298 ? -28.101 -17.117 -28.335 1.00 54.03  ? 561  HIS A CG  1 
ATOM   2023 N  ND1 . HIS A 1 298 ? -27.716 -17.937 -29.367 1.00 51.46  ? 561  HIS A ND1 1 
ATOM   2024 C  CD2 . HIS A 1 298 ? -27.644 -17.685 -27.200 1.00 50.58  ? 561  HIS A CD2 1 
ATOM   2025 C  CE1 . HIS A 1 298 ? -27.061 -18.967 -28.879 1.00 60.28  ? 561  HIS A CE1 1 
ATOM   2026 N  NE2 . HIS A 1 298 ? -27.004 -18.834 -27.550 1.00 55.62  ? 561  HIS A NE2 1 
ATOM   2027 N  N   . LYS A 1 299 ? -26.956 -13.562 -28.086 1.00 46.43  ? 562  LYS A N   1 
ATOM   2028 C  CA  . LYS A 1 299 ? -25.639 -12.910 -28.037 1.00 49.43  ? 562  LYS A CA  1 
ATOM   2029 C  C   . LYS A 1 299 ? -25.488 -12.220 -26.677 1.00 53.12  ? 562  LYS A C   1 
ATOM   2030 O  O   . LYS A 1 299 ? -24.472 -12.465 -26.013 1.00 57.76  ? 562  LYS A O   1 
ATOM   2031 C  CB  . LYS A 1 299 ? -25.499 -11.990 -29.241 1.00 48.95  ? 562  LYS A CB  1 
ATOM   2032 C  CG  . LYS A 1 299 ? -24.180 -11.245 -29.268 1.00 49.77  ? 562  LYS A CG  1 
ATOM   2033 C  CD  . LYS A 1 299 ? -23.880 -10.592 -30.601 1.00 53.09  ? 562  LYS A CD  1 
ATOM   2034 C  CE  . LYS A 1 299 ? -22.708 -9.646  -30.505 1.00 53.36  ? 562  LYS A CE  1 
ATOM   2035 N  NZ  . LYS A 1 299 ? -21.453 -10.295 -30.946 1.00 63.50  ? 562  LYS A NZ  1 
ATOM   2036 N  N   . LYS A 1 300 ? -26.465 -11.425 -26.238 1.00 56.24  ? 563  LYS A N   1 
ATOM   2037 C  CA  . LYS A 1 300 ? -26.334 -10.660 -24.962 1.00 59.51  ? 563  LYS A CA  1 
ATOM   2038 C  C   . LYS A 1 300 ? -26.279 -11.667 -23.821 1.00 50.12  ? 563  LYS A C   1 
ATOM   2039 O  O   . LYS A 1 300 ? -25.496 -11.467 -22.898 1.00 56.96  ? 563  LYS A O   1 
ATOM   2040 C  CB  . LYS A 1 300 ? -27.492 -9.687  -24.678 1.00 75.74  ? 563  LYS A CB  1 
ATOM   2041 C  CG  . LYS A 1 300 ? -27.741 -8.591  -25.713 1.00 89.63  ? 563  LYS A CG  1 
ATOM   2042 C  CD  . LYS A 1 300 ? -26.712 -7.479  -25.732 1.00 98.23  ? 563  LYS A CD  1 
ATOM   2043 C  CE  . LYS A 1 300 ? -26.734 -6.670  -27.017 1.00 106.36 ? 563  LYS A CE  1 
ATOM   2044 N  NZ  . LYS A 1 300 ? -25.518 -5.833  -27.171 1.00 109.24 ? 563  LYS A NZ  1 
ATOM   2045 N  N   . LEU A 1 301 ? -27.121 -12.690 -23.875 1.00 49.12  ? 564  LEU A N   1 
ATOM   2046 C  CA  . LEU A 1 301 ? -27.228 -13.688 -22.783 1.00 54.84  ? 564  LEU A CA  1 
ATOM   2047 C  C   . LEU A 1 301 ? -25.886 -14.451 -22.683 1.00 61.03  ? 564  LEU A C   1 
ATOM   2048 O  O   . LEU A 1 301 ? -25.337 -14.511 -21.563 1.00 50.42  ? 564  LEU A O   1 
ATOM   2049 C  CB  . LEU A 1 301 ? -28.431 -14.597 -23.054 1.00 56.02  ? 564  LEU A CB  1 
ATOM   2050 C  CG  . LEU A 1 301 ? -29.822 -13.995 -22.781 1.00 57.06  ? 564  LEU A CG  1 
ATOM   2051 C  CD1 . LEU A 1 301 ? -30.902 -14.926 -23.274 1.00 53.85  ? 564  LEU A CD1 1 
ATOM   2052 C  CD2 . LEU A 1 301 ? -30.058 -13.728 -21.303 1.00 57.28  ? 564  LEU A CD2 1 
ATOM   2053 N  N   . ALA A 1 302 ? -25.328 -14.930 -23.810 1.00 56.97  ? 565  ALA A N   1 
ATOM   2054 C  CA  . ALA A 1 302 ? -24.049 -15.681 -23.860 1.00 53.64  ? 565  ALA A CA  1 
ATOM   2055 C  C   . ALA A 1 302 ? -22.913 -14.771 -23.395 1.00 52.85  ? 565  ALA A C   1 
ATOM   2056 O  O   . ALA A 1 302 ? -22.146 -15.200 -22.534 1.00 60.80  ? 565  ALA A O   1 
ATOM   2057 C  CB  . ALA A 1 302 ? -23.790 -16.236 -25.243 1.00 51.63  ? 565  ALA A CB  1 
ATOM   2058 N  N   . GLU A 1 303 ? -22.835 -13.545 -23.905 1.00 52.78  ? 566  GLU A N   1 
ATOM   2059 C  CA  . GLU A 1 303 ? -21.765 -12.585 -23.519 1.00 55.11  ? 566  GLU A CA  1 
ATOM   2060 C  C   . GLU A 1 303 ? -21.742 -12.433 -22.001 1.00 48.94  ? 566  GLU A C   1 
ATOM   2061 O  O   . GLU A 1 303 ? -20.653 -12.284 -21.443 1.00 52.92  ? 566  GLU A O   1 
ATOM   2062 C  CB  . GLU A 1 303 ? -21.957 -11.211 -24.156 1.00 55.22  ? 566  GLU A CB  1 
ATOM   2063 C  CG  . GLU A 1 303 ? -21.510 -11.178 -25.604 1.00 65.35  ? 566  GLU A CG  1 
ATOM   2064 C  CD  . GLU A 1 303 ? -21.815 -9.924  -26.411 1.00 67.51  ? 566  GLU A CD  1 
ATOM   2065 O  OE1 . GLU A 1 303 ? -22.293 -8.930  -25.827 1.00 77.66  ? 566  GLU A OE1 1 
ATOM   2066 O  OE2 . GLU A 1 303 ? -21.562 -9.948  -27.633 1.00 71.00  ? 566  GLU A OE2 1 
ATOM   2067 N  N   . ALA A 1 304 ? -22.899 -12.444 -21.364 1.00 45.86  ? 567  ALA A N   1 
ATOM   2068 C  CA  . ALA A 1 304 ? -23.016 -12.227 -19.905 1.00 54.72  ? 567  ALA A CA  1 
ATOM   2069 C  C   . ALA A 1 304 ? -22.446 -13.444 -19.167 1.00 51.12  ? 567  ALA A C   1 
ATOM   2070 O  O   . ALA A 1 304 ? -21.660 -13.252 -18.220 1.00 60.54  ? 567  ALA A O   1 
ATOM   2071 C  CB  . ALA A 1 304 ? -24.460 -11.958 -19.515 1.00 51.37  ? 567  ALA A CB  1 
ATOM   2072 N  N   . ILE A 1 305 ? -22.849 -14.650 -19.580 1.00 52.85  ? 568  ILE A N   1 
ATOM   2073 C  CA  . ILE A 1 305 ? -22.375 -15.910 -18.952 1.00 49.28  ? 568  ILE A CA  1 
ATOM   2074 C  C   . ILE A 1 305 ? -20.845 -15.863 -19.028 1.00 47.36  ? 568  ILE A C   1 
ATOM   2075 O  O   . ILE A 1 305 ? -20.202 -15.963 -17.989 1.00 45.28  ? 568  ILE A O   1 
ATOM   2076 C  CB  . ILE A 1 305 ? -22.976 -17.143 -19.644 1.00 55.09  ? 568  ILE A CB  1 
ATOM   2077 C  CG1 . ILE A 1 305 ? -24.480 -17.286 -19.368 1.00 53.79  ? 568  ILE A CG1 1 
ATOM   2078 C  CG2 . ILE A 1 305 ? -22.193 -18.414 -19.281 1.00 55.80  ? 568  ILE A CG2 1 
ATOM   2079 C  CD1 . ILE A 1 305 ? -24.866 -17.376 -17.908 1.00 48.89  ? 568  ILE A CD1 1 
ATOM   2080 N  N   . PHE A 1 306 ? -20.293 -15.565 -20.199 1.00 48.71  ? 569  PHE A N   1 
ATOM   2081 C  CA  . PHE A 1 306 ? -18.824 -15.534 -20.395 1.00 59.38  ? 569  PHE A CA  1 
ATOM   2082 C  C   . PHE A 1 306 ? -18.206 -14.484 -19.459 1.00 70.61  ? 569  PHE A C   1 
ATOM   2083 O  O   . PHE A 1 306 ? -17.238 -14.837 -18.755 1.00 62.43  ? 569  PHE A O   1 
ATOM   2084 C  CB  . PHE A 1 306 ? -18.465 -15.319 -21.865 1.00 52.32  ? 569  PHE A CB  1 
ATOM   2085 C  CG  . PHE A 1 306 ? -18.399 -16.596 -22.660 1.00 50.56  ? 569  PHE A CG  1 
ATOM   2086 C  CD1 . PHE A 1 306 ? -17.531 -17.609 -22.286 1.00 56.37  ? 569  PHE A CD1 1 
ATOM   2087 C  CD2 . PHE A 1 306 ? -19.150 -16.768 -23.806 1.00 45.42  ? 569  PHE A CD2 1 
ATOM   2088 C  CE1 . PHE A 1 306 ? -17.458 -18.787 -23.013 1.00 56.13  ? 569  PHE A CE1 1 
ATOM   2089 C  CE2 . PHE A 1 306 ? -19.085 -17.950 -24.532 1.00 53.30  ? 569  PHE A CE2 1 
ATOM   2090 C  CZ  . PHE A 1 306 ? -18.243 -18.966 -24.129 1.00 52.98  ? 569  PHE A CZ  1 
ATOM   2091 N  N   . LYS A 1 307 ? -18.762 -13.263 -19.436 1.00 76.38  ? 570  LYS A N   1 
ATOM   2092 C  CA  . LYS A 1 307 ? -18.198 -12.083 -18.718 1.00 69.65  ? 570  LYS A CA  1 
ATOM   2093 C  C   . LYS A 1 307 ? -18.321 -12.291 -17.212 1.00 61.00  ? 570  LYS A C   1 
ATOM   2094 O  O   . LYS A 1 307 ? -17.330 -12.067 -16.515 1.00 62.58  ? 570  LYS A O   1 
ATOM   2095 C  CB  . LYS A 1 307 ? -18.928 -10.778 -19.063 1.00 81.47  ? 570  LYS A CB  1 
ATOM   2096 C  CG  . LYS A 1 307 ? -18.346 -9.999  -20.227 1.00 88.40  ? 570  LYS A CG  1 
ATOM   2097 C  CD  . LYS A 1 307 ? -19.061 -8.704  -20.551 1.00 99.49  ? 570  LYS A CD  1 
ATOM   2098 C  CE  . LYS A 1 307 ? -18.549 -8.070  -21.831 1.00 101.07 ? 570  LYS A CE  1 
ATOM   2099 N  NZ  . LYS A 1 307 ? -18.561 -9.023  -22.970 1.00 100.08 ? 570  LYS A NZ  1 
ATOM   2100 N  N   . LEU A 1 308 ? -19.494 -12.716 -16.743 1.00 52.27  ? 571  LEU A N   1 
ATOM   2101 C  CA  . LEU A 1 308 ? -19.895 -12.544 -15.328 1.00 53.38  ? 571  LEU A CA  1 
ATOM   2102 C  C   . LEU A 1 308 ? -19.709 -13.836 -14.510 1.00 57.74  ? 571  LEU A C   1 
ATOM   2103 O  O   . LEU A 1 308 ? -19.532 -13.723 -13.281 1.00 55.38  ? 571  LEU A O   1 
ATOM   2104 C  CB  . LEU A 1 308 ? -21.352 -12.068 -15.343 1.00 64.45  ? 571  LEU A CB  1 
ATOM   2105 C  CG  . LEU A 1 308 ? -21.619 -10.832 -16.220 1.00 63.37  ? 571  LEU A CG  1 
ATOM   2106 C  CD1 . LEU A 1 308 ? -23.105 -10.597 -16.371 1.00 63.27  ? 571  LEU A CD1 1 
ATOM   2107 C  CD2 . LEU A 1 308 ? -20.941 -9.581  -15.669 1.00 60.49  ? 571  LEU A CD2 1 
ATOM   2108 N  N   . THR A 1 309 ? -19.808 -15.017 -15.123 1.00 51.55  ? 572  THR A N   1 
ATOM   2109 C  CA  . THR A 1 309 ? -19.670 -16.315 -14.415 1.00 52.68  ? 572  THR A CA  1 
ATOM   2110 C  C   . THR A 1 309 ? -18.316 -16.958 -14.747 1.00 53.29  ? 572  THR A C   1 
ATOM   2111 O  O   . THR A 1 309 ? -17.718 -17.434 -13.811 1.00 67.34  ? 572  THR A O   1 
ATOM   2112 C  CB  . THR A 1 309 ? -20.823 -17.282 -14.711 1.00 55.73  ? 572  THR A CB  1 
ATOM   2113 O  OG1 . THR A 1 309 ? -20.877 -17.523 -16.120 1.00 51.71  ? 572  THR A OG1 1 
ATOM   2114 C  CG2 . THR A 1 309 ? -22.150 -16.754 -14.226 1.00 65.27  ? 572  THR A CG2 1 
ATOM   2115 N  N   . TYR A 1 310 ? -17.849 -16.936 -16.006 1.00 53.09  ? 573  TYR A N   1 
ATOM   2116 C  CA  . TYR A 1 310 ? -16.634 -17.662 -16.484 1.00 54.40  ? 573  TYR A CA  1 
ATOM   2117 C  C   . TYR A 1 310 ? -15.356 -16.808 -16.268 1.00 56.06  ? 573  TYR A C   1 
ATOM   2118 O  O   . TYR A 1 310 ? -14.405 -17.339 -15.673 1.00 59.47  ? 573  TYR A O   1 
ATOM   2119 C  CB  . TYR A 1 310 ? -16.799 -18.128 -17.949 1.00 49.81  ? 573  TYR A CB  1 
ATOM   2120 C  CG  . TYR A 1 310 ? -17.807 -19.234 -18.214 1.00 44.91  ? 573  TYR A CG  1 
ATOM   2121 C  CD1 . TYR A 1 310 ? -18.702 -19.654 -17.254 1.00 40.71  ? 573  TYR A CD1 1 
ATOM   2122 C  CD2 . TYR A 1 310 ? -17.941 -19.800 -19.470 1.00 45.12  ? 573  TYR A CD2 1 
ATOM   2123 C  CE1 . TYR A 1 310 ? -19.658 -20.619 -17.512 1.00 42.37  ? 573  TYR A CE1 1 
ATOM   2124 C  CE2 . TYR A 1 310 ? -18.870 -20.799 -19.732 1.00 44.81  ? 573  TYR A CE2 1 
ATOM   2125 C  CZ  . TYR A 1 310 ? -19.747 -21.210 -18.753 1.00 45.55  ? 573  TYR A CZ  1 
ATOM   2126 O  OH  . TYR A 1 310 ? -20.708 -22.172 -18.979 1.00 48.83  ? 573  TYR A OH  1 
ATOM   2127 N  N   . GLN A 1 311 ? -15.306 -15.566 -16.781 1.00 52.69  ? 574  GLN A N   1 
ATOM   2128 C  CA  . GLN A 1 311 ? -14.128 -14.659 -16.756 1.00 49.88  ? 574  GLN A CA  1 
ATOM   2129 C  C   . GLN A 1 311 ? -14.079 -13.852 -15.447 1.00 58.25  ? 574  GLN A C   1 
ATOM   2130 O  O   . GLN A 1 311 ? -13.137 -13.034 -15.317 1.00 56.84  ? 574  GLN A O   1 
ATOM   2131 C  CB  . GLN A 1 311 ? -14.137 -13.710 -17.947 1.00 50.01  ? 574  GLN A CB  1 
ATOM   2132 C  CG  . GLN A 1 311 ? -13.981 -14.421 -19.277 1.00 51.46  ? 574  GLN A CG  1 
ATOM   2133 C  CD  . GLN A 1 311 ? -14.234 -13.472 -20.420 1.00 56.11  ? 574  GLN A CD  1 
ATOM   2134 O  OE1 . GLN A 1 311 ? -14.914 -12.469 -20.264 1.00 66.04  ? 574  GLN A OE1 1 
ATOM   2135 N  NE2 . GLN A 1 311 ? -13.720 -13.791 -21.594 1.00 65.01  ? 574  GLN A NE2 1 
ATOM   2136 N  N   . ASN A 1 312 ? -15.028 -14.096 -14.527 1.00 62.03  ? 575  ASN A N   1 
ATOM   2137 C  CA  . ASN A 1 312 ? -15.052 -13.635 -13.108 1.00 61.33  ? 575  ASN A CA  1 
ATOM   2138 C  C   . ASN A 1 312 ? -15.851 -14.648 -12.288 1.00 60.59  ? 575  ASN A C   1 
ATOM   2139 O  O   . ASN A 1 312 ? -17.069 -14.715 -12.449 1.00 85.04  ? 575  ASN A O   1 
ATOM   2140 C  CB  . ASN A 1 312 ? -15.736 -12.280 -12.917 1.00 58.13  ? 575  ASN A CB  1 
ATOM   2141 C  CG  . ASN A 1 312 ? -14.897 -11.125 -13.401 1.00 59.28  ? 575  ASN A CG  1 
ATOM   2142 O  OD1 . ASN A 1 312 ? -13.987 -10.685 -12.697 1.00 74.24  ? 575  ASN A OD1 1 
ATOM   2143 N  ND2 . ASN A 1 312 ? -15.196 -10.630 -14.591 1.00 59.76  ? 575  ASN A ND2 1 
ATOM   2144 N  N   . LYS A 1 313 ? -15.190 -15.447 -11.469 1.00 67.15  ? 576  LYS A N   1 
ATOM   2145 C  CA  . LYS A 1 313 ? -15.859 -16.522 -10.700 1.00 69.88  ? 576  LYS A CA  1 
ATOM   2146 C  C   . LYS A 1 313 ? -16.071 -16.014 -9.278  1.00 70.25  ? 576  LYS A C   1 
ATOM   2147 O  O   . LYS A 1 313 ? -15.281 -15.194 -8.829  1.00 67.96  ? 576  LYS A O   1 
ATOM   2148 C  CB  . LYS A 1 313 ? -15.013 -17.793 -10.761 1.00 72.45  ? 576  LYS A CB  1 
ATOM   2149 C  CG  . LYS A 1 313 ? -14.534 -18.111 -12.164 1.00 70.46  ? 576  LYS A CG  1 
ATOM   2150 C  CD  . LYS A 1 313 ? -13.805 -19.418 -12.282 1.00 71.63  ? 576  LYS A CD  1 
ATOM   2151 C  CE  . LYS A 1 313 ? -13.045 -19.544 -13.586 1.00 66.85  ? 576  LYS A CE  1 
ATOM   2152 N  NZ  . LYS A 1 313 ? -12.375 -18.278 -13.968 1.00 69.91  ? 576  LYS A NZ  1 
ATOM   2153 N  N   . VAL A 1 314 ? -17.153 -16.431 -8.641  1.00 63.31  ? 577  VAL A N   1 
ATOM   2154 C  CA  . VAL A 1 314 ? -17.362 -16.215 -7.192  1.00 60.18  ? 577  VAL A CA  1 
ATOM   2155 C  C   . VAL A 1 314 ? -17.708 -17.590 -6.663  1.00 60.72  ? 577  VAL A C   1 
ATOM   2156 O  O   . VAL A 1 314 ? -18.592 -18.253 -7.258  1.00 55.57  ? 577  VAL A O   1 
ATOM   2157 C  CB  . VAL A 1 314 ? -18.461 -15.183 -6.850  1.00 60.25  ? 577  VAL A CB  1 
ATOM   2158 C  CG1 . VAL A 1 314 ? -18.814 -15.245 -5.372  1.00 58.76  ? 577  VAL A CG1 1 
ATOM   2159 C  CG2 . VAL A 1 314 ? -18.097 -13.759 -7.243  1.00 56.55  ? 577  VAL A CG2 1 
ATOM   2160 N  N   . VAL A 1 315 ? -17.010 -17.979 -5.600  1.00 66.79  ? 578  VAL A N   1 
ATOM   2161 C  CA  . VAL A 1 315 ? -17.051 -19.351 -5.044  1.00 65.27  ? 578  VAL A CA  1 
ATOM   2162 C  C   . VAL A 1 315 ? -17.144 -19.240 -3.532  1.00 63.38  ? 578  VAL A C   1 
ATOM   2163 O  O   . VAL A 1 315 ? -16.372 -18.447 -2.977  1.00 68.27  ? 578  VAL A O   1 
ATOM   2164 C  CB  . VAL A 1 315 ? -15.810 -20.167 -5.439  1.00 69.18  ? 578  VAL A CB  1 
ATOM   2165 C  CG1 . VAL A 1 315 ? -16.009 -21.636 -5.110  1.00 73.17  ? 578  VAL A CG1 1 
ATOM   2166 C  CG2 . VAL A 1 315 ? -15.424 -19.970 -6.898  1.00 69.53  ? 578  VAL A CG2 1 
ATOM   2167 N  N   . ARG A 1 316 ? -18.007 -20.064 -2.942  1.00 68.06  ? 579  ARG A N   1 
ATOM   2168 C  CA  . ARG A 1 316 ? -18.150 -20.276 -1.486  1.00 80.51  ? 579  ARG A CA  1 
ATOM   2169 C  C   . ARG A 1 316 ? -17.560 -21.655 -1.140  1.00 93.11  ? 579  ARG A C   1 
ATOM   2170 O  O   . ARG A 1 316 ? -18.136 -22.675 -1.560  1.00 80.20  ? 579  ARG A O   1 
ATOM   2171 C  CB  . ARG A 1 316 ? -19.613 -20.080 -1.077  1.00 77.61  ? 579  ARG A CB  1 
ATOM   2172 C  CG  . ARG A 1 316 ? -20.622 -20.965 -1.787  1.00 83.83  ? 579  ARG A CG  1 
ATOM   2173 C  CD  . ARG A 1 316 ? -21.995 -20.892 -1.135  1.00 94.02  ? 579  ARG A CD  1 
ATOM   2174 N  NE  . ARG A 1 316 ? -22.467 -19.530 -0.898  1.00 97.57  ? 579  ARG A NE  1 
ATOM   2175 C  CZ  . ARG A 1 316 ? -23.744 -19.154 -0.852  1.00 101.05 ? 579  ARG A CZ  1 
ATOM   2176 N  NH1 . ARG A 1 316 ? -24.041 -17.886 -0.626  1.00 98.65  ? 579  ARG A NH1 1 
ATOM   2177 N  NH2 . ARG A 1 316 ? -24.722 -20.028 -1.034  1.00 104.49 ? 579  ARG A NH2 1 
ATOM   2178 N  N   . VAL A 1 317 ? -16.437 -21.661 -0.406  1.00 106.17 ? 580  VAL A N   1 
ATOM   2179 C  CA  . VAL A 1 317 ? -15.604 -22.856 -0.070  1.00 101.55 ? 580  VAL A CA  1 
ATOM   2180 C  C   . VAL A 1 317 ? -15.803 -23.213 1.405   1.00 100.95 ? 580  VAL A C   1 
ATOM   2181 O  O   . VAL A 1 317 ? -16.090 -22.303 2.186   1.00 97.89  ? 580  VAL A O   1 
ATOM   2182 C  CB  . VAL A 1 317 ? -14.114 -22.586 -0.353  1.00 104.48 ? 580  VAL A CB  1 
ATOM   2183 C  CG1 . VAL A 1 317 ? -13.312 -23.873 -0.334  1.00 109.77 ? 580  VAL A CG1 1 
ATOM   2184 C  CG2 . VAL A 1 317 ? -13.889 -21.844 -1.661  1.00 110.52 ? 580  VAL A CG2 1 
ATOM   2185 N  N   . GLN A 1 318 ? -15.610 -24.486 1.765   1.00 113.06 ? 581  GLN A N   1 
ATOM   2186 C  CA  . GLN A 1 318 ? -15.516 -24.976 3.172   1.00 117.04 ? 581  GLN A CA  1 
ATOM   2187 C  C   . GLN A 1 318 ? -14.071 -24.867 3.684   1.00 132.25 ? 581  GLN A C   1 
ATOM   2188 O  O   . GLN A 1 318 ? -13.149 -25.124 2.883   1.00 144.44 ? 581  GLN A O   1 
ATOM   2189 C  CB  . GLN A 1 318 ? -15.944 -26.440 3.228   1.00 108.10 ? 581  GLN A CB  1 
ATOM   2190 C  CG  . GLN A 1 318 ? -17.424 -26.631 2.979   1.00 109.41 ? 581  GLN A CG  1 
ATOM   2191 C  CD  . GLN A 1 318 ? -18.202 -26.398 4.247   1.00 100.72 ? 581  GLN A CD  1 
ATOM   2192 O  OE1 . GLN A 1 318 ? -18.581 -27.337 4.941   1.00 93.84  ? 581  GLN A OE1 1 
ATOM   2193 N  NE2 . GLN A 1 318 ? -18.419 -25.137 4.574   1.00 106.88 ? 581  GLN A NE2 1 
ATOM   2194 N  N   . ARG A 1 319 ? -13.867 -24.541 4.968   1.00 131.13 ? 582  ARG A N   1 
ATOM   2195 C  CA  . ARG A 1 319 ? -12.519 -24.539 5.614   1.00 137.51 ? 582  ARG A CA  1 
ATOM   2196 C  C   . ARG A 1 319 ? -12.645 -25.009 7.063   1.00 140.82 ? 582  ARG A C   1 
ATOM   2197 O  O   . ARG A 1 319 ? -13.204 -24.286 7.880   1.00 131.65 ? 582  ARG A O   1 
ATOM   2198 C  CB  . ARG A 1 319 ? -11.870 -23.150 5.521   1.00 134.55 ? 582  ARG A CB  1 
ATOM   2199 C  CG  . ARG A 1 319 ? -10.407 -23.114 5.948   1.00 126.28 ? 582  ARG A CG  1 
ATOM   2200 C  CD  . ARG A 1 319 ? -9.578  -22.042 5.256   1.00 125.61 ? 582  ARG A CD  1 
ATOM   2201 N  NE  . ARG A 1 319 ? -9.976  -20.678 5.595   1.00 125.19 ? 582  ARG A NE  1 
ATOM   2202 C  CZ  . ARG A 1 319 ? -9.386  -19.888 6.495   1.00 128.83 ? 582  ARG A CZ  1 
ATOM   2203 N  NH1 . ARG A 1 319 ? -8.338  -20.305 7.186   1.00 133.50 ? 582  ARG A NH1 1 
ATOM   2204 N  NH2 . ARG A 1 319 ? -9.843  -18.663 6.693   1.00 128.34 ? 582  ARG A NH2 1 
ATOM   2205 N  N   . PRO A 1 320 ? -12.140 -26.220 7.424   1.00 156.47 ? 583  PRO A N   1 
ATOM   2206 C  CA  . PRO A 1 320 ? -12.311 -26.780 8.772   1.00 145.62 ? 583  PRO A CA  1 
ATOM   2207 C  C   . PRO A 1 320 ? -11.885 -25.894 9.959   1.00 133.76 ? 583  PRO A C   1 
ATOM   2208 O  O   . PRO A 1 320 ? -12.550 -25.940 10.987  1.00 124.78 ? 583  PRO A O   1 
ATOM   2209 C  CB  . PRO A 1 320 ? -11.417 -28.035 8.753   1.00 153.71 ? 583  PRO A CB  1 
ATOM   2210 C  CG  . PRO A 1 320 ? -11.370 -28.449 7.296   1.00 156.32 ? 583  PRO A CG  1 
ATOM   2211 C  CD  . PRO A 1 320 ? -11.413 -27.143 6.531   1.00 160.31 ? 583  PRO A CD  1 
ATOM   2212 N  N   . THR A 1 321 ? -10.802 -25.124 9.796   1.00 124.52 ? 584  THR A N   1 
ATOM   2213 C  CA  . THR A 1 321 ? -10.152 -24.278 10.842  1.00 123.22 ? 584  THR A CA  1 
ATOM   2214 C  C   . THR A 1 321 ? -11.209 -23.573 11.708  1.00 104.46 ? 584  THR A C   1 
ATOM   2215 O  O   . THR A 1 321 ? -11.134 -23.719 12.951  1.00 96.93  ? 584  THR A O   1 
ATOM   2216 C  CB  . THR A 1 321 ? -9.205  -23.254 10.198  1.00 130.14 ? 584  THR A CB  1 
ATOM   2217 O  OG1 . THR A 1 321 ? -9.948  -22.561 9.196   1.00 131.62 ? 584  THR A OG1 1 
ATOM   2218 C  CG2 . THR A 1 321 ? -7.967  -23.862 9.571   1.00 125.61 ? 584  THR A CG2 1 
ATOM   2219 N  N   . THR A 1 325 ? -15.331 -24.616 10.854  1.00 132.72 ? 588  THR A N   1 
ATOM   2220 C  CA  . THR A 1 325 ? -15.875 -24.655 9.466   1.00 128.52 ? 588  THR A CA  1 
ATOM   2221 C  C   . THR A 1 325 ? -16.567 -23.315 9.153   1.00 132.52 ? 588  THR A C   1 
ATOM   2222 O  O   . THR A 1 325 ? -17.764 -23.150 9.508   1.00 121.10 ? 588  THR A O   1 
ATOM   2223 C  CB  . THR A 1 325 ? -16.767 -25.890 9.264   1.00 132.49 ? 588  THR A CB  1 
ATOM   2224 O  OG1 . THR A 1 325 ? -15.928 -27.046 9.270   1.00 137.95 ? 588  THR A OG1 1 
ATOM   2225 C  CG2 . THR A 1 325 ? -17.547 -25.879 7.968   1.00 134.87 ? 588  THR A CG2 1 
ATOM   2226 N  N   . VAL A 1 326 ? -15.829 -22.386 8.531   1.00 128.98 ? 589  VAL A N   1 
ATOM   2227 C  CA  . VAL A 1 326 ? -16.376 -21.142 7.906   1.00 128.34 ? 589  VAL A CA  1 
ATOM   2228 C  C   . VAL A 1 326 ? -16.583 -21.400 6.410   1.00 130.38 ? 589  VAL A C   1 
ATOM   2229 O  O   . VAL A 1 326 ? -16.042 -22.399 5.885   1.00 132.48 ? 589  VAL A O   1 
ATOM   2230 C  CB  . VAL A 1 326 ? -15.479 -19.901 8.108   1.00 128.82 ? 589  VAL A CB  1 
ATOM   2231 C  CG1 . VAL A 1 326 ? -15.026 -19.740 9.551   1.00 136.91 ? 589  VAL A CG1 1 
ATOM   2232 C  CG2 . VAL A 1 326 ? -14.286 -19.881 7.160   1.00 126.93 ? 589  VAL A CG2 1 
ATOM   2233 N  N   . MET A 1 327 ? -17.323 -20.501 5.759   1.00 123.48 ? 590  MET A N   1 
ATOM   2234 C  CA  . MET A 1 327 ? -17.535 -20.479 4.293   1.00 115.59 ? 590  MET A CA  1 
ATOM   2235 C  C   . MET A 1 327 ? -16.757 -19.294 3.710   1.00 105.15 ? 590  MET A C   1 
ATOM   2236 O  O   . MET A 1 327 ? -17.279 -18.178 3.717   1.00 122.80 ? 590  MET A O   1 
ATOM   2237 C  CB  . MET A 1 327 ? -19.028 -20.361 3.966   1.00 119.55 ? 590  MET A CB  1 
ATOM   2238 C  CG  . MET A 1 327 ? -19.366 -20.778 2.550   1.00 124.44 ? 590  MET A CG  1 
ATOM   2239 S  SD  . MET A 1 327 ? -19.301 -22.576 2.306   1.00 129.65 ? 590  MET A SD  1 
ATOM   2240 C  CE  . MET A 1 327 ? -20.798 -23.081 3.156   1.00 111.33 ? 590  MET A CE  1 
ATOM   2241 N  N   . ASP A 1 328 ? -15.533 -19.526 3.247   1.00 99.59  ? 591  ASP A N   1 
ATOM   2242 C  CA  . ASP A 1 328 ? -14.705 -18.481 2.592   1.00 98.91  ? 591  ASP A CA  1 
ATOM   2243 C  C   . ASP A 1 328 ? -15.366 -18.086 1.275   1.00 93.71  ? 591  ASP A C   1 
ATOM   2244 O  O   . ASP A 1 328 ? -15.813 -18.976 0.536   1.00 95.60  ? 591  ASP A O   1 
ATOM   2245 C  CB  . ASP A 1 328 ? -13.276 -18.966 2.372   1.00 110.70 ? 591  ASP A CB  1 
ATOM   2246 C  CG  . ASP A 1 328 ? -12.598 -19.307 3.682   1.00 120.87 ? 591  ASP A CG  1 
ATOM   2247 O  OD1 . ASP A 1 328 ? -12.588 -18.430 4.572   1.00 122.48 ? 591  ASP A OD1 1 
ATOM   2248 O  OD2 . ASP A 1 328 ? -12.122 -20.455 3.812   1.00 119.15 ? 591  ASP A OD2 1 
ATOM   2249 N  N   . ILE A 1 329 ? -15.455 -16.788 1.015   1.00 78.70  ? 592  ILE A N   1 
ATOM   2250 C  CA  . ILE A 1 329 ? -16.013 -16.273 -0.257  1.00 68.71  ? 592  ILE A CA  1 
ATOM   2251 C  C   . ILE A 1 329 ? -14.820 -15.762 -1.026  1.00 67.15  ? 592  ILE A C   1 
ATOM   2252 O  O   . ILE A 1 329 ? -14.252 -14.736 -0.664  1.00 70.56  ? 592  ILE A O   1 
ATOM   2253 C  CB  . ILE A 1 329 ? -17.093 -15.195 -0.055  1.00 73.32  ? 592  ILE A CB  1 
ATOM   2254 C  CG1 . ILE A 1 329 ? -18.275 -15.730 0.757   1.00 76.23  ? 592  ILE A CG1 1 
ATOM   2255 C  CG2 . ILE A 1 329 ? -17.547 -14.629 -1.392  1.00 70.87  ? 592  ILE A CG2 1 
ATOM   2256 C  CD1 . ILE A 1 329 ? -18.794 -17.064 0.292   1.00 74.87  ? 592  ILE A CD1 1 
ATOM   2257 N  N   . ILE A 1 330 ? -14.450 -16.505 -2.046  1.00 78.00  ? 593  ILE A N   1 
ATOM   2258 C  CA  . ILE A 1 330 ? -13.203 -16.244 -2.802  1.00 77.44  ? 593  ILE A CA  1 
ATOM   2259 C  C   . ILE A 1 330 ? -13.626 -15.942 -4.237  1.00 69.48  ? 593  ILE A C   1 
ATOM   2260 O  O   . ILE A 1 330 ? -14.778 -16.224 -4.594  1.00 66.16  ? 593  ILE A O   1 
ATOM   2261 C  CB  . ILE A 1 330 ? -12.268 -17.455 -2.644  1.00 78.35  ? 593  ILE A CB  1 
ATOM   2262 C  CG1 . ILE A 1 330 ? -12.774 -18.676 -3.423  1.00 82.30  ? 593  ILE A CG1 1 
ATOM   2263 C  CG2 . ILE A 1 330 ? -12.120 -17.765 -1.161  1.00 75.20  ? 593  ILE A CG2 1 
ATOM   2264 C  CD1 . ILE A 1 330 ? -11.830 -19.867 -3.417  1.00 85.35  ? 593  ILE A CD1 1 
ATOM   2265 N  N   . SER A 1 331 ? -12.719 -15.364 -5.028  0.26 69.14  ? 594  SER A N   1 
ATOM   2266 C  CA  . SER A 1 331 ? -12.951 -14.980 -6.445  0.26 69.78  ? 594  SER A CA  1 
ATOM   2267 C  C   . SER A 1 331 ? -11.658 -15.135 -7.251  0.26 70.89  ? 594  SER A C   1 
ATOM   2268 O  O   . SER A 1 331 ? -10.568 -15.074 -6.648  0.26 71.94  ? 594  SER A O   1 
ATOM   2269 C  CB  . SER A 1 331 ? -13.490 -13.576 -6.545  0.26 68.99  ? 594  SER A CB  1 
ATOM   2270 O  OG  . SER A 1 331 ? -12.433 -12.629 -6.611  0.26 68.52  ? 594  SER A OG  1 
ATOM   2271 N  N   . ARG A 1 332 ? -11.790 -15.326 -8.566  0.26 70.42  ? 595  ARG A N   1 
ATOM   2272 C  CA  . ARG A 1 332 ? -10.658 -15.389 -9.527  0.26 71.03  ? 595  ARG A CA  1 
ATOM   2273 C  C   . ARG A 1 332 ? -11.199 -15.189 -10.946 0.26 70.27  ? 595  ARG A C   1 
ATOM   2274 O  O   . ARG A 1 332 ? -12.394 -15.471 -11.165 0.26 71.94  ? 595  ARG A O   1 
ATOM   2275 C  CB  . ARG A 1 332 ? -9.904  -16.715 -9.381  0.26 73.74  ? 595  ARG A CB  1 
ATOM   2276 C  CG  . ARG A 1 332 ? -10.330 -17.813 -10.347 0.26 75.12  ? 595  ARG A CG  1 
ATOM   2277 C  CD  . ARG A 1 332 ? -9.415  -19.019 -10.245 0.26 76.70  ? 595  ARG A CD  1 
ATOM   2278 N  NE  . ARG A 1 332 ? -8.027  -18.665 -10.535 0.26 76.19  ? 595  ARG A NE  1 
ATOM   2279 C  CZ  . ARG A 1 332 ? -6.978  -18.898 -9.743  0.26 76.52  ? 595  ARG A CZ  1 
ATOM   2280 N  NH1 . ARG A 1 332 ? -7.124  -19.520 -8.585  0.26 76.87  ? 595  ARG A NH1 1 
ATOM   2281 N  NH2 . ARG A 1 332 ? -5.771  -18.520 -10.128 0.26 75.39  ? 595  ARG A NH2 1 
ATOM   2282 N  N   . ARG A 1 333 ? -10.343 -14.743 -11.869 1.00 67.81  ? 596  ARG A N   1 
ATOM   2283 C  CA  . ARG A 1 333 ? -10.739 -14.468 -13.266 1.00 71.42  ? 596  ARG A CA  1 
ATOM   2284 C  C   . ARG A 1 333 ? -10.437 -15.684 -14.159 1.00 74.71  ? 596  ARG A C   1 
ATOM   2285 O  O   . ARG A 1 333 ? -11.250 -15.956 -15.084 1.00 70.95  ? 596  ARG A O   1 
ATOM   2286 C  CB  . ARG A 1 333 ? -10.033 -13.172 -13.645 1.00 71.54  ? 596  ARG A CB  1 
ATOM   2287 C  CG  . ARG A 1 333 ? -10.410 -12.014 -12.723 1.00 76.76  ? 596  ARG A CG  1 
ATOM   2288 C  CD  . ARG A 1 333 ? -10.407 -10.703 -13.490 1.00 93.40  ? 596  ARG A CD  1 
ATOM   2289 N  NE  . ARG A 1 333 ? -11.118 -10.868 -14.766 1.00 106.51 ? 596  ARG A NE  1 
ATOM   2290 C  CZ  . ARG A 1 333 ? -10.740 -10.375 -15.953 1.00 105.99 ? 596  ARG A CZ  1 
ATOM   2291 N  NH1 . ARG A 1 333 ? -9.641  -9.642  -16.071 1.00 107.34 ? 596  ARG A NH1 1 
ATOM   2292 N  NH2 . ARG A 1 333 ? -11.472 -10.630 -17.027 1.00 100.59 ? 596  ARG A NH2 1 
ATOM   2293 N  N   . ASP A 1 334 ? -9.359  -16.418 -13.859 1.00 64.92  ? 597  ASP A N   1 
ATOM   2294 C  CA  . ASP A 1 334 ? -8.757  -17.438 -14.761 1.00 61.23  ? 597  ASP A CA  1 
ATOM   2295 C  C   . ASP A 1 334 ? -9.114  -18.842 -14.247 1.00 55.96  ? 597  ASP A C   1 
ATOM   2296 O  O   . ASP A 1 334 ? -9.933  -18.954 -13.305 1.00 54.31  ? 597  ASP A O   1 
ATOM   2297 C  CB  . ASP A 1 334 ? -7.262  -17.161 -14.985 1.00 67.01  ? 597  ASP A CB  1 
ATOM   2298 C  CG  . ASP A 1 334 ? -6.315  -17.587 -13.873 1.00 68.43  ? 597  ASP A CG  1 
ATOM   2299 O  OD1 . ASP A 1 334 ? -6.784  -17.970 -12.797 1.00 65.32  ? 597  ASP A OD1 1 
ATOM   2300 O  OD2 . ASP A 1 334 ? -5.095  -17.539 -14.107 1.00 93.17  ? 597  ASP A OD2 1 
ATOM   2301 N  N   . GLN A 1 335 ? -8.468  -19.853 -14.843 0.26 53.29  ? 598  GLN A N   1 
ATOM   2302 C  CA  . GLN A 1 335 ? -8.717  -21.305 -14.649 0.26 51.16  ? 598  GLN A CA  1 
ATOM   2303 C  C   . GLN A 1 335 ? -10.103 -21.646 -15.204 0.26 48.98  ? 598  GLN A C   1 
ATOM   2304 O  O   . GLN A 1 335 ? -10.895 -20.718 -15.463 0.26 50.54  ? 598  GLN A O   1 
ATOM   2305 C  CB  . GLN A 1 335 ? -8.565  -21.704 -13.178 0.26 51.59  ? 598  GLN A CB  1 
ATOM   2306 C  CG  . GLN A 1 335 ? -7.179  -21.409 -12.620 0.26 51.28  ? 598  GLN A CG  1 
ATOM   2307 C  CD  . GLN A 1 335 ? -6.976  -21.925 -11.217 0.26 51.17  ? 598  GLN A CD  1 
ATOM   2308 O  OE1 . GLN A 1 335 ? -7.903  -22.391 -10.560 0.26 53.02  ? 598  GLN A OE1 1 
ATOM   2309 N  NE2 . GLN A 1 335 ? -5.747  -21.834 -10.739 0.26 52.18  ? 598  GLN A NE2 1 
ATOM   2310 N  N   . ARG A 1 336 ? -10.355 -22.936 -15.419 0.26 47.43  ? 599  ARG A N   1 
ATOM   2311 C  CA  . ARG A 1 336 ? -11.681 -23.478 -15.808 0.26 46.08  ? 599  ARG A CA  1 
ATOM   2312 C  C   . ARG A 1 336 ? -12.569 -23.569 -14.566 0.26 43.76  ? 599  ARG A C   1 
ATOM   2313 O  O   . ARG A 1 336 ? -13.793 -23.392 -14.708 0.26 46.05  ? 599  ARG A O   1 
ATOM   2314 C  CB  . ARG A 1 336 ? -11.543 -24.873 -16.425 0.26 46.05  ? 599  ARG A CB  1 
ATOM   2315 C  CG  . ARG A 1 336 ? -12.856 -25.476 -16.905 0.26 45.54  ? 599  ARG A CG  1 
ATOM   2316 C  CD  . ARG A 1 336 ? -13.435 -24.708 -18.075 0.26 45.16  ? 599  ARG A CD  1 
ATOM   2317 N  NE  . ARG A 1 336 ? -12.553 -24.787 -19.227 0.26 44.99  ? 599  ARG A NE  1 
ATOM   2318 C  CZ  . ARG A 1 336 ? -12.643 -24.035 -20.316 0.26 44.75  ? 599  ARG A CZ  1 
ATOM   2319 N  NH1 . ARG A 1 336 ? -13.592 -23.120 -20.428 0.26 43.86  ? 599  ARG A NH1 1 
ATOM   2320 N  NH2 . ARG A 1 336 ? -11.772 -24.208 -21.294 0.26 45.44  ? 599  ARG A NH2 1 
ATOM   2321 N  N   . GLY A 1 337 ? -11.968 -23.862 -13.408 0.26 40.31  ? 600  GLY A N   1 
ATOM   2322 C  CA  . GLY A 1 337 ? -12.688 -24.279 -12.192 0.26 37.75  ? 600  GLY A CA  1 
ATOM   2323 C  C   . GLY A 1 337 ? -13.513 -25.525 -12.463 0.26 35.44  ? 600  GLY A C   1 
ATOM   2324 O  O   . GLY A 1 337 ? -13.156 -26.297 -13.368 0.26 33.48  ? 600  GLY A O   1 
ATOM   2325 N  N   . SER A 1 338 ? -14.555 -25.734 -11.668 0.26 34.10  ? 601  SER A N   1 
ATOM   2326 C  CA  . SER A 1 338 ? -15.710 -26.603 -11.990 0.26 34.36  ? 601  SER A CA  1 
ATOM   2327 C  C   . SER A 1 338 ? -16.882 -25.673 -12.305 0.26 33.74  ? 601  SER A C   1 
ATOM   2328 O  O   . SER A 1 338 ? -16.608 -24.508 -12.683 0.26 32.86  ? 601  SER A O   1 
ATOM   2329 C  CB  . SER A 1 338 ? -15.996 -27.560 -10.867 0.26 35.47  ? 601  SER A CB  1 
ATOM   2330 O  OG  . SER A 1 338 ? -14.827 -28.291 -10.517 0.26 35.21  ? 601  SER A OG  1 
ATOM   2331 N  N   . GLY A 1 339 ? -18.124 -26.148 -12.182 0.26 34.27  ? 602  GLY A N   1 
ATOM   2332 C  CA  . GLY A 1 339 ? -19.324 -25.302 -12.318 0.26 33.18  ? 602  GLY A CA  1 
ATOM   2333 C  C   . GLY A 1 339 ? -19.728 -25.048 -13.760 0.26 33.52  ? 602  GLY A C   1 
ATOM   2334 O  O   . GLY A 1 339 ? -20.877 -24.636 -13.963 0.26 34.42  ? 602  GLY A O   1 
ATOM   2335 N  N   . GLN A 1 340 ? -18.849 -25.283 -14.741 0.26 33.61  ? 603  GLN A N   1 
ATOM   2336 C  CA  . GLN A 1 340 ? -19.150 -25.007 -16.173 0.26 32.76  ? 603  GLN A CA  1 
ATOM   2337 C  C   . GLN A 1 340 ? -19.766 -26.261 -16.815 0.26 32.75  ? 603  GLN A C   1 
ATOM   2338 O  O   . GLN A 1 340 ? -19.100 -27.315 -16.828 0.26 30.19  ? 603  GLN A O   1 
ATOM   2339 C  CB  . GLN A 1 340 ? -17.898 -24.509 -16.895 0.26 32.27  ? 603  GLN A CB  1 
ATOM   2340 C  CG  . GLN A 1 340 ? -17.397 -23.171 -16.370 0.26 31.61  ? 603  GLN A CG  1 
ATOM   2341 C  CD  . GLN A 1 340 ? -16.261 -22.596 -17.182 0.26 30.66  ? 603  GLN A CD  1 
ATOM   2342 O  OE1 . GLN A 1 340 ? -16.001 -23.005 -18.311 0.26 31.06  ? 603  GLN A OE1 1 
ATOM   2343 N  NE2 . GLN A 1 340 ? -15.574 -21.625 -16.608 0.26 29.81  ? 603  GLN A NE2 1 
ATOM   2344 N  N   . VAL A 1 341 ? -21.001 -26.135 -17.320 0.26 32.53  ? 604  VAL A N   1 
ATOM   2345 C  CA  . VAL A 1 341 ? -21.802 -27.234 -17.940 0.26 32.95  ? 604  VAL A CA  1 
ATOM   2346 C  C   . VAL A 1 341 ? -21.263 -27.522 -19.349 0.26 33.04  ? 604  VAL A C   1 
ATOM   2347 O  O   . VAL A 1 341 ? -21.533 -28.623 -19.861 0.26 31.87  ? 604  VAL A O   1 
ATOM   2348 C  CB  . VAL A 1 341 ? -23.307 -26.893 -17.963 0.26 33.60  ? 604  VAL A CB  1 
ATOM   2349 C  CG1 . VAL A 1 341 ? -23.643 -25.810 -18.980 0.26 33.38  ? 604  VAL A CG1 1 
ATOM   2350 C  CG2 . VAL A 1 341 ? -24.165 -28.129 -18.201 0.26 33.84  ? 604  VAL A CG2 1 
ATOM   2351 N  N   . VAL A 1 342 ? -20.535 -26.575 -19.952 0.26 34.00  ? 605  VAL A N   1 
ATOM   2352 C  CA  . VAL A 1 342 ? -19.922 -26.728 -21.307 0.26 35.35  ? 605  VAL A CA  1 
ATOM   2353 C  C   . VAL A 1 342 ? -18.402 -26.863 -21.154 0.26 36.09  ? 605  VAL A C   1 
ATOM   2354 O  O   . VAL A 1 342 ? -17.682 -26.496 -22.097 0.26 36.77  ? 605  VAL A O   1 
ATOM   2355 C  CB  . VAL A 1 342 ? -20.313 -25.577 -22.256 0.26 34.82  ? 605  VAL A CB  1 
ATOM   2356 C  CG1 . VAL A 1 342 ? -21.762 -25.694 -22.690 0.26 34.84  ? 605  VAL A CG1 1 
ATOM   2357 C  CG2 . VAL A 1 342 ? -20.042 -24.207 -21.655 0.26 35.27  ? 605  VAL A CG2 1 
ATOM   2358 N  N   . THR A 1 343 ? -17.937 -27.381 -20.012 1.00 38.30  ? 606  THR A N   1 
ATOM   2359 C  CA  . THR A 1 343 ? -16.490 -27.614 -19.748 1.00 40.82  ? 606  THR A CA  1 
ATOM   2360 C  C   . THR A 1 343 ? -15.905 -28.574 -20.797 1.00 36.32  ? 606  THR A C   1 
ATOM   2361 O  O   . THR A 1 343 ? -14.835 -28.262 -21.363 1.00 37.44  ? 606  THR A O   1 
ATOM   2362 C  CB  . THR A 1 343 ? -16.274 -28.153 -18.332 1.00 43.38  ? 606  THR A CB  1 
ATOM   2363 O  OG1 . THR A 1 343 ? -16.589 -27.088 -17.440 1.00 42.87  ? 606  THR A OG1 1 
ATOM   2364 C  CG2 . THR A 1 343 ? -14.849 -28.587 -18.071 1.00 46.15  ? 606  THR A CG2 1 
ATOM   2365 N  N   . TYR A 1 344 ? -16.591 -29.687 -21.059 1.00 34.45  ? 607  TYR A N   1 
ATOM   2366 C  CA  . TYR A 1 344 ? -16.167 -30.685 -22.062 1.00 33.71  ? 607  TYR A CA  1 
ATOM   2367 C  C   . TYR A 1 344 ? -15.958 -29.955 -23.402 1.00 33.49  ? 607  TYR A C   1 
ATOM   2368 O  O   . TYR A 1 344 ? -14.913 -30.133 -24.068 1.00 33.36  ? 607  TYR A O   1 
ATOM   2369 C  CB  . TYR A 1 344 ? -17.169 -31.836 -22.178 1.00 33.38  ? 607  TYR A CB  1 
ATOM   2370 C  CG  . TYR A 1 344 ? -16.770 -32.867 -23.210 1.00 34.63  ? 607  TYR A CG  1 
ATOM   2371 C  CD1 . TYR A 1 344 ? -15.842 -33.847 -22.925 1.00 35.52  ? 607  TYR A CD1 1 
ATOM   2372 C  CD2 . TYR A 1 344 ? -17.252 -32.821 -24.501 1.00 37.24  ? 607  TYR A CD2 1 
ATOM   2373 C  CE1 . TYR A 1 344 ? -15.436 -34.764 -23.878 1.00 34.83  ? 607  TYR A CE1 1 
ATOM   2374 C  CE2 . TYR A 1 344 ? -16.862 -33.738 -25.468 1.00 37.42  ? 607  TYR A CE2 1 
ATOM   2375 C  CZ  . TYR A 1 344 ? -15.944 -34.718 -25.160 1.00 36.87  ? 607  TYR A CZ  1 
ATOM   2376 O  OH  . TYR A 1 344 ? -15.509 -35.592 -26.127 1.00 38.33  ? 607  TYR A OH  1 
ATOM   2377 N  N   . GLY A 1 345 ? -16.957 -29.185 -23.829 1.00 30.94  ? 608  GLY A N   1 
ATOM   2378 C  CA  . GLY A 1 345 ? -16.963 -28.616 -25.190 1.00 32.10  ? 608  GLY A CA  1 
ATOM   2379 C  C   . GLY A 1 345 ? -15.884 -27.566 -25.339 1.00 33.01  ? 608  GLY A C   1 
ATOM   2380 O  O   . GLY A 1 345 ? -15.210 -27.565 -26.357 1.00 34.49  ? 608  GLY A O   1 
ATOM   2381 N  N   . LEU A 1 346 ? -15.720 -26.719 -24.324 1.00 31.17  ? 609  LEU A N   1 
ATOM   2382 C  CA  . LEU A 1 346 ? -14.760 -25.601 -24.345 1.00 36.21  ? 609  LEU A CA  1 
ATOM   2383 C  C   . LEU A 1 346 ? -13.328 -26.151 -24.171 1.00 34.44  ? 609  LEU A C   1 
ATOM   2384 O  O   . LEU A 1 346 ? -12.415 -25.651 -24.916 1.00 31.77  ? 609  LEU A O   1 
ATOM   2385 C  CB  . LEU A 1 346 ? -15.159 -24.594 -23.261 1.00 36.24  ? 609  LEU A CB  1 
ATOM   2386 C  CG  . LEU A 1 346 ? -16.426 -23.779 -23.523 1.00 35.57  ? 609  LEU A CG  1 
ATOM   2387 C  CD1 . LEU A 1 346 ? -16.598 -22.729 -22.433 1.00 37.33  ? 609  LEU A CD1 1 
ATOM   2388 C  CD2 . LEU A 1 346 ? -16.417 -23.098 -24.887 1.00 34.08  ? 609  LEU A CD2 1 
ATOM   2389 N  N   . ASN A 1 347 ? -13.141 -27.170 -23.323 1.00 31.28  ? 610  ASN A N   1 
ATOM   2390 C  CA  . ASN A 1 347 ? -11.875 -27.955 -23.270 1.00 33.90  ? 610  ASN A CA  1 
ATOM   2391 C  C   . ASN A 1 347 ? -11.555 -28.564 -24.644 1.00 32.62  ? 610  ASN A C   1 
ATOM   2392 O  O   . ASN A 1 347 ? -10.452 -28.406 -25.111 1.00 33.05  ? 610  ASN A O   1 
ATOM   2393 C  CB  . ASN A 1 347 ? -11.924 -29.050 -22.215 1.00 31.45  ? 610  ASN A CB  1 
ATOM   2394 C  CG  . ASN A 1 347 ? -11.786 -28.486 -20.819 1.00 33.61  ? 610  ASN A CG  1 
ATOM   2395 O  OD1 . ASN A 1 347 ? -11.506 -27.309 -20.636 1.00 33.40  ? 610  ASN A OD1 1 
ATOM   2396 N  ND2 . ASN A 1 347 ? -12.012 -29.316 -19.815 1.00 38.41  ? 610  ASN A ND2 1 
ATOM   2397 N  N   . THR A 1 348 ? -12.503 -29.193 -25.314 1.00 35.54  ? 611  THR A N   1 
ATOM   2398 C  CA  . THR A 1 348 ? -12.238 -29.763 -26.649 1.00 33.82  ? 611  THR A CA  1 
ATOM   2399 C  C   . THR A 1 348 ? -11.766 -28.622 -27.567 1.00 36.08  ? 611  THR A C   1 
ATOM   2400 O  O   . THR A 1 348 ? -10.759 -28.799 -28.278 1.00 33.51  ? 611  THR A O   1 
ATOM   2401 C  CB  . THR A 1 348 ? -13.467 -30.506 -27.159 1.00 32.68  ? 611  THR A CB  1 
ATOM   2402 O  OG1 . THR A 1 348 ? -13.863 -31.478 -26.187 1.00 35.00  ? 611  THR A OG1 1 
ATOM   2403 C  CG2 . THR A 1 348 ? -13.248 -31.141 -28.514 1.00 32.19  ? 611  THR A CG2 1 
ATOM   2404 N  N   . PHE A 1 349 ? -12.484 -27.498 -27.565 1.00 36.08  ? 612  PHE A N   1 
ATOM   2405 C  CA  . PHE A 1 349 ? -12.185 -26.329 -28.433 1.00 37.55  ? 612  PHE A CA  1 
ATOM   2406 C  C   . PHE A 1 349 ? -10.727 -25.874 -28.232 1.00 35.32  ? 612  PHE A C   1 
ATOM   2407 O  O   . PHE A 1 349 ? -9.985  -25.776 -29.214 1.00 32.11  ? 612  PHE A O   1 
ATOM   2408 C  CB  . PHE A 1 349 ? -13.114 -25.166 -28.102 1.00 36.79  ? 612  PHE A CB  1 
ATOM   2409 C  CG  . PHE A 1 349 ? -12.830 -23.979 -28.968 1.00 32.83  ? 612  PHE A CG  1 
ATOM   2410 C  CD1 . PHE A 1 349 ? -13.308 -23.944 -30.255 1.00 36.71  ? 612  PHE A CD1 1 
ATOM   2411 C  CD2 . PHE A 1 349 ? -12.085 -22.924 -28.504 1.00 34.81  ? 612  PHE A CD2 1 
ATOM   2412 C  CE1 . PHE A 1 349 ? -13.038 -22.877 -31.091 1.00 37.21  ? 612  PHE A CE1 1 
ATOM   2413 C  CE2 . PHE A 1 349 ? -11.805 -21.860 -29.342 1.00 38.81  ? 612  PHE A CE2 1 
ATOM   2414 C  CZ  . PHE A 1 349 ? -12.270 -21.846 -30.636 1.00 37.26  ? 612  PHE A CZ  1 
ATOM   2415 N  N   . THR A 1 350 ? -10.348 -25.576 -26.990 1.00 31.90  ? 613  THR A N   1 
ATOM   2416 C  CA  . THR A 1 350 ? -9.047  -24.972 -26.629 1.00 41.47  ? 613  THR A CA  1 
ATOM   2417 C  C   . THR A 1 350 ? -7.915  -25.986 -26.900 1.00 40.35  ? 613  THR A C   1 
ATOM   2418 O  O   . THR A 1 350 ? -6.853  -25.584 -27.444 1.00 47.36  ? 613  THR A O   1 
ATOM   2419 C  CB  . THR A 1 350 ? -9.111  -24.461 -25.184 1.00 40.79  ? 613  THR A CB  1 
ATOM   2420 O  OG1 . THR A 1 350 ? -10.145 -23.477 -25.138 1.00 39.86  ? 613  THR A OG1 1 
ATOM   2421 C  CG2 . THR A 1 350 ? -7.796  -23.871 -24.713 1.00 39.96  ? 613  THR A CG2 1 
ATOM   2422 N  N   . ASN A 1 351 ? -8.157  -27.269 -26.618 1.00 36.07  ? 614  ASN A N   1 
ATOM   2423 C  CA  . ASN A 1 351 ? -7.216  -28.384 -26.898 1.00 37.53  ? 614  ASN A CA  1 
ATOM   2424 C  C   . ASN A 1 351 ? -7.033  -28.502 -28.414 1.00 33.68  ? 614  ASN A C   1 
ATOM   2425 O  O   . ASN A 1 351 ? -5.912  -28.609 -28.821 1.00 30.80  ? 614  ASN A O   1 
ATOM   2426 C  CB  . ASN A 1 351 ? -7.663  -29.697 -26.239 1.00 35.87  ? 614  ASN A CB  1 
ATOM   2427 C  CG  . ASN A 1 351 ? -6.525  -30.674 -25.993 1.00 36.91  ? 614  ASN A CG  1 
ATOM   2428 O  OD1 . ASN A 1 351 ? -5.368  -30.354 -26.234 1.00 34.94  ? 614  ASN A OD1 1 
ATOM   2429 N  ND2 . ASN A 1 351 ? -6.827  -31.854 -25.465 1.00 37.09  ? 614  ASN A ND2 1 
ATOM   2430 N  N   . MET A 1 352 ? -8.100  -28.444 -29.199 1.00 32.00  ? 615  MET A N   1 
ATOM   2431 C  CA  . MET A 1 352 ? -8.022  -28.458 -30.681 1.00 36.72  ? 615  MET A CA  1 
ATOM   2432 C  C   . MET A 1 352 ? -7.091  -27.323 -31.140 1.00 37.06  ? 615  MET A C   1 
ATOM   2433 O  O   . MET A 1 352 ? -6.213  -27.571 -31.980 1.00 34.25  ? 615  MET A O   1 
ATOM   2434 C  CB  . MET A 1 352 ? -9.400  -28.282 -31.344 1.00 38.33  ? 615  MET A CB  1 
ATOM   2435 C  CG  . MET A 1 352 ? -10.255 -29.537 -31.383 1.00 35.83  ? 615  MET A CG  1 
ATOM   2436 S  SD  . MET A 1 352 ? -11.968 -29.302 -32.033 1.00 38.70  ? 615  MET A SD  1 
ATOM   2437 C  CE  . MET A 1 352 ? -11.644 -29.030 -33.767 1.00 34.20  ? 615  MET A CE  1 
ATOM   2438 N  N   . GLU A 1 353 ? -7.276  -26.136 -30.584 1.00 32.94  ? 616  GLU A N   1 
ATOM   2439 C  CA  . GLU A 1 353 ? -6.514  -24.924 -30.941 1.00 36.61  ? 616  GLU A CA  1 
ATOM   2440 C  C   . GLU A 1 353 ? -5.027  -25.130 -30.583 1.00 37.27  ? 616  GLU A C   1 
ATOM   2441 O  O   . GLU A 1 353 ? -4.153  -24.909 -31.447 1.00 32.91  ? 616  GLU A O   1 
ATOM   2442 C  CB  . GLU A 1 353 ? -7.150  -23.766 -30.181 1.00 37.95  ? 616  GLU A CB  1 
ATOM   2443 C  CG  . GLU A 1 353 ? -6.539  -22.384 -30.390 1.00 39.85  ? 616  GLU A CG  1 
ATOM   2444 C  CD  . GLU A 1 353 ? -6.879  -21.445 -29.235 1.00 44.95  ? 616  GLU A CD  1 
ATOM   2445 O  OE1 . GLU A 1 353 ? -8.112  -21.086 -29.025 1.00 44.17  ? 616  GLU A OE1 1 
ATOM   2446 O  OE2 . GLU A 1 353 ? -5.956  -21.179 -28.467 1.00 42.60  ? 616  GLU A OE2 1 
ATOM   2447 N  N   . ALA A 1 354 ? -4.749  -25.547 -29.348 1.00 33.76  ? 617  ALA A N   1 
ATOM   2448 C  CA  . ALA A 1 354 ? -3.377  -25.772 -28.863 1.00 34.79  ? 617  ALA A CA  1 
ATOM   2449 C  C   . ALA A 1 354 ? -2.679  -26.802 -29.765 1.00 37.92  ? 617  ALA A C   1 
ATOM   2450 O  O   . ALA A 1 354 ? -1.513  -26.541 -30.144 1.00 35.22  ? 617  ALA A O   1 
ATOM   2451 C  CB  . ALA A 1 354 ? -3.417  -26.183 -27.423 1.00 37.23  ? 617  ALA A CB  1 
ATOM   2452 N  N   . GLN A 1 355 ? -3.366  -27.903 -30.113 1.00 34.44  ? 618  GLN A N   1 
ATOM   2453 C  CA  . GLN A 1 355 ? -2.760  -29.000 -30.893 1.00 33.93  ? 618  GLN A CA  1 
ATOM   2454 C  C   . GLN A 1 355 ? -2.501  -28.563 -32.329 1.00 35.87  ? 618  GLN A C   1 
ATOM   2455 O  O   . GLN A 1 355 ? -1.460  -29.022 -32.857 1.00 36.45  ? 618  GLN A O   1 
ATOM   2456 C  CB  . GLN A 1 355 ? -3.535  -30.311 -30.867 1.00 31.81  ? 618  GLN A CB  1 
ATOM   2457 C  CG  . GLN A 1 355 ? -3.713  -30.881 -29.467 1.00 33.71  ? 618  GLN A CG  1 
ATOM   2458 C  CD  . GLN A 1 355 ? -2.418  -31.016 -28.715 1.00 37.04  ? 618  GLN A CD  1 
ATOM   2459 O  OE1 . GLN A 1 355 ? -1.413  -31.492 -29.231 1.00 36.55  ? 618  GLN A OE1 1 
ATOM   2460 N  NE2 . GLN A 1 355 ? -2.452  -30.631 -27.462 1.00 37.86  ? 618  GLN A NE2 1 
ATOM   2461 N  N   . LEU A 1 356 ? -3.352  -27.749 -32.950 1.00 35.51  ? 619  LEU A N   1 
ATOM   2462 C  CA  . LEU A 1 356 ? -3.064  -27.199 -34.316 1.00 39.65  ? 619  LEU A CA  1 
ATOM   2463 C  C   . LEU A 1 356 ? -1.818  -26.289 -34.252 1.00 37.35  ? 619  LEU A C   1 
ATOM   2464 O  O   . LEU A 1 356 ? -1.055  -26.286 -35.203 1.00 35.31  ? 619  LEU A O   1 
ATOM   2465 C  CB  . LEU A 1 356 ? -4.207  -26.336 -34.829 1.00 39.76  ? 619  LEU A CB  1 
ATOM   2466 C  CG  . LEU A 1 356 ? -5.347  -27.020 -35.560 1.00 45.56  ? 619  LEU A CG  1 
ATOM   2467 C  CD1 . LEU A 1 356 ? -6.478  -26.017 -35.710 1.00 43.96  ? 619  LEU A CD1 1 
ATOM   2468 C  CD2 . LEU A 1 356 ? -4.917  -27.558 -36.921 1.00 48.50  ? 619  LEU A CD2 1 
ATOM   2469 N  N   . ILE A 1 357 ? -1.675  -25.500 -33.195 1.00 35.78  ? 620  ILE A N   1 
ATOM   2470 C  CA  . ILE A 1 357 ? -0.554  -24.537 -33.063 1.00 38.69  ? 620  ILE A CA  1 
ATOM   2471 C  C   . ILE A 1 357 ? 0.734   -25.328 -32.846 1.00 43.80  ? 620  ILE A C   1 
ATOM   2472 O  O   . ILE A 1 357 ? 1.716   -25.039 -33.530 1.00 43.80  ? 620  ILE A O   1 
ATOM   2473 C  CB  . ILE A 1 357 ? -0.835  -23.529 -31.946 1.00 40.76  ? 620  ILE A CB  1 
ATOM   2474 C  CG1 . ILE A 1 357 ? -1.906  -22.528 -32.385 1.00 42.57  ? 620  ILE A CG1 1 
ATOM   2475 C  CG2 . ILE A 1 357 ? 0.452   -22.839 -31.528 1.00 41.62  ? 620  ILE A CG2 1 
ATOM   2476 C  CD1 . ILE A 1 357 ? -2.598  -21.798 -31.237 1.00 45.29  ? 620  ILE A CD1 1 
ATOM   2477 N  N   . ARG A 1 358 ? 0.700   -26.358 -31.999 1.00 43.86  ? 621  ARG A N   1 
ATOM   2478 C  CA  . ARG A 1 358 ? 1.835   -27.293 -31.870 1.00 36.09  ? 621  ARG A CA  1 
ATOM   2479 C  C   . ARG A 1 358 ? 2.164   -27.909 -33.235 1.00 38.24  ? 621  ARG A C   1 
ATOM   2480 O  O   . ARG A 1 358 ? 3.361   -28.061 -33.564 1.00 38.72  ? 621  ARG A O   1 
ATOM   2481 C  CB  . ARG A 1 358 ? 1.573   -28.381 -30.834 1.00 36.10  ? 621  ARG A CB  1 
ATOM   2482 C  CG  . ARG A 1 358 ? 2.798   -29.269 -30.642 1.00 34.66  ? 621  ARG A CG  1 
ATOM   2483 C  CD  . ARG A 1 358 ? 2.746   -30.174 -29.423 1.00 37.03  ? 621  ARG A CD  1 
ATOM   2484 N  NE  . ARG A 1 358 ? 3.919   -31.022 -29.317 1.00 37.40  ? 621  ARG A NE  1 
ATOM   2485 C  CZ  . ARG A 1 358 ? 4.123   -32.002 -28.437 1.00 37.63  ? 621  ARG A CZ  1 
ATOM   2486 N  NH1 . ARG A 1 358 ? 3.179   -32.394 -27.597 1.00 33.70  ? 621  ARG A NH1 1 
ATOM   2487 N  NH2 . ARG A 1 358 ? 5.289   -32.627 -28.439 1.00 40.87  ? 621  ARG A NH2 1 
ATOM   2488 N  N   . GLN A 1 359 ? 1.180   -28.367 -33.988 1.00 35.56  ? 622  GLN A N   1 
ATOM   2489 C  CA  . GLN A 1 359 ? 1.419   -28.868 -35.372 1.00 38.96  ? 622  GLN A CA  1 
ATOM   2490 C  C   . GLN A 1 359 ? 2.062   -27.736 -36.225 1.00 43.14  ? 622  GLN A C   1 
ATOM   2491 O  O   . GLN A 1 359 ? 2.945   -28.032 -37.067 1.00 48.58  ? 622  GLN A O   1 
ATOM   2492 C  CB  . GLN A 1 359 ? 0.120   -29.370 -36.006 1.00 39.11  ? 622  GLN A CB  1 
ATOM   2493 C  CG  . GLN A 1 359 ? -0.291  -30.773 -35.610 1.00 39.30  ? 622  GLN A CG  1 
ATOM   2494 C  CD  . GLN A 1 359 ? -1.297  -31.397 -36.554 1.00 40.97  ? 622  GLN A CD  1 
ATOM   2495 O  OE1 . GLN A 1 359 ? -0.969  -31.926 -37.624 1.00 38.85  ? 622  GLN A OE1 1 
ATOM   2496 N  NE2 . GLN A 1 359 ? -2.546  -31.381 -36.133 1.00 35.91  ? 622  GLN A NE2 1 
ATOM   2497 N  N   . MET A 1 360 ? 1.635   -26.479 -36.083 1.00 40.95  ? 623  MET A N   1 
ATOM   2498 C  CA  . MET A 1 360 ? 2.211   -25.346 -36.874 1.00 45.12  ? 623  MET A CA  1 
ATOM   2499 C  C   . MET A 1 360 ? 3.719   -25.225 -36.552 1.00 44.23  ? 623  MET A C   1 
ATOM   2500 O  O   . MET A 1 360 ? 4.526   -25.100 -37.480 1.00 39.17  ? 623  MET A O   1 
ATOM   2501 C  CB  . MET A 1 360 ? 1.533   -24.018 -36.535 1.00 45.21  ? 623  MET A CB  1 
ATOM   2502 C  CG  . MET A 1 360 ? 0.277   -23.709 -37.355 1.00 49.95  ? 623  MET A CG  1 
ATOM   2503 S  SD  . MET A 1 360 ? -0.551  -22.340 -36.549 1.00 51.23  ? 623  MET A SD  1 
ATOM   2504 C  CE  . MET A 1 360 ? -2.258  -22.793 -36.843 1.00 55.99  ? 623  MET A CE  1 
ATOM   2505 N  N   . GLU A 1 361 ? 4.057   -25.330 -35.273 1.00 36.98  ? 624  GLU A N   1 
ATOM   2506 C  CA  . GLU A 1 361 ? 5.415   -25.160 -34.749 1.00 42.59  ? 624  GLU A CA  1 
ATOM   2507 C  C   . GLU A 1 361 ? 6.294   -26.261 -35.328 1.00 44.89  ? 624  GLU A C   1 
ATOM   2508 O  O   . GLU A 1 361 ? 7.360   -25.927 -35.795 1.00 44.50  ? 624  GLU A O   1 
ATOM   2509 C  CB  . GLU A 1 361 ? 5.412   -25.175 -33.227 1.00 41.94  ? 624  GLU A CB  1 
ATOM   2510 C  CG  . GLU A 1 361 ? 6.760   -24.788 -32.669 1.00 45.75  ? 624  GLU A CG  1 
ATOM   2511 C  CD  . GLU A 1 361 ? 6.779   -24.564 -31.169 1.00 51.42  ? 624  GLU A CD  1 
ATOM   2512 O  OE1 . GLU A 1 361 ? 7.875   -24.651 -30.585 1.00 52.41  ? 624  GLU A OE1 1 
ATOM   2513 O  OE2 . GLU A 1 361 ? 5.689   -24.309 -30.582 1.00 54.32  ? 624  GLU A OE2 1 
ATOM   2514 N  N   . GLY A 1 362 ? 5.844   -27.511 -35.331 1.00 44.31  ? 625  GLY A N   1 
ATOM   2515 C  CA  . GLY A 1 362 ? 6.614   -28.627 -35.913 1.00 48.87  ? 625  GLY A CA  1 
ATOM   2516 C  C   . GLY A 1 362 ? 6.845   -28.456 -37.419 1.00 48.38  ? 625  GLY A C   1 
ATOM   2517 O  O   . GLY A 1 362 ? 7.881   -28.883 -37.916 1.00 47.75  ? 625  GLY A O   1 
ATOM   2518 N  N   . GLU A 1 363 ? 5.881   -27.916 -38.151 1.00 44.44  ? 626  GLU A N   1 
ATOM   2519 C  CA  . GLU A 1 363 ? 6.009   -27.716 -39.614 1.00 49.29  ? 626  GLU A CA  1 
ATOM   2520 C  C   . GLU A 1 363 ? 6.818   -26.436 -39.901 1.00 49.30  ? 626  GLU A C   1 
ATOM   2521 O  O   . GLU A 1 363 ? 7.012   -26.133 -41.087 1.00 48.54  ? 626  GLU A O   1 
ATOM   2522 C  CB  . GLU A 1 363 ? 4.625   -27.705 -40.250 1.00 49.16  ? 626  GLU A CB  1 
ATOM   2523 C  CG  . GLU A 1 363 ? 4.011   -29.106 -40.257 1.00 50.15  ? 626  GLU A CG  1 
ATOM   2524 C  CD  . GLU A 1 363 ? 2.600   -29.191 -40.823 1.00 51.62  ? 626  GLU A CD  1 
ATOM   2525 O  OE1 . GLU A 1 363 ? 2.323   -28.525 -41.851 1.00 45.45  ? 626  GLU A OE1 1 
ATOM   2526 O  OE2 . GLU A 1 363 ? 1.783   -29.895 -40.218 1.00 44.38  ? 626  GLU A OE2 1 
ATOM   2527 N  N   . GLY A 1 364 ? 7.275   -25.728 -38.866 1.00 44.39  ? 627  GLY A N   1 
ATOM   2528 C  CA  . GLY A 1 364 ? 7.955   -24.428 -38.999 1.00 51.72  ? 627  GLY A CA  1 
ATOM   2529 C  C   . GLY A 1 364 ? 7.113   -23.363 -39.699 1.00 62.39  ? 627  GLY A C   1 
ATOM   2530 O  O   . GLY A 1 364 ? 7.714   -22.495 -40.371 1.00 63.95  ? 627  GLY A O   1 
ATOM   2531 N  N   . VAL A 1 365 ? 5.786   -23.346 -39.507 1.00 57.90  ? 628  VAL A N   1 
ATOM   2532 C  CA  . VAL A 1 365 ? 4.900   -22.262 -40.025 1.00 52.38  ? 628  VAL A CA  1 
ATOM   2533 C  C   . VAL A 1 365 ? 5.313   -20.914 -39.401 1.00 56.29  ? 628  VAL A C   1 
ATOM   2534 O  O   . VAL A 1 365 ? 5.039   -19.874 -40.006 1.00 64.07  ? 628  VAL A O   1 
ATOM   2535 C  CB  . VAL A 1 365 ? 3.410   -22.577 -39.783 1.00 52.37  ? 628  VAL A CB  1 
ATOM   2536 C  CG1 . VAL A 1 365 ? 2.511   -21.461 -40.285 1.00 50.60  ? 628  VAL A CG1 1 
ATOM   2537 C  CG2 . VAL A 1 365 ? 2.995   -23.884 -40.443 1.00 55.20  ? 628  VAL A CG2 1 
ATOM   2538 N  N   . PHE A 1 366 ? 5.916   -20.913 -38.219 1.00 55.43  ? 629  PHE A N   1 
ATOM   2539 C  CA  . PHE A 1 366 ? 6.405   -19.702 -37.511 1.00 62.52  ? 629  PHE A CA  1 
ATOM   2540 C  C   . PHE A 1 366 ? 7.674   -20.078 -36.731 1.00 66.67  ? 629  PHE A C   1 
ATOM   2541 O  O   . PHE A 1 366 ? 7.792   -21.229 -36.288 1.00 65.44  ? 629  PHE A O   1 
ATOM   2542 C  CB  . PHE A 1 366 ? 5.323   -19.147 -36.577 1.00 60.15  ? 629  PHE A CB  1 
ATOM   2543 C  CG  . PHE A 1 366 ? 5.068   -19.990 -35.348 1.00 57.88  ? 629  PHE A CG  1 
ATOM   2544 C  CD1 . PHE A 1 366 ? 4.127   -21.008 -35.368 1.00 57.05  ? 629  PHE A CD1 1 
ATOM   2545 C  CD2 . PHE A 1 366 ? 5.776   -19.778 -34.174 1.00 58.35  ? 629  PHE A CD2 1 
ATOM   2546 C  CE1 . PHE A 1 366 ? 3.885   -21.783 -34.245 1.00 53.38  ? 629  PHE A CE1 1 
ATOM   2547 C  CE2 . PHE A 1 366 ? 5.526   -20.545 -33.043 1.00 63.64  ? 629  PHE A CE2 1 
ATOM   2548 C  CZ  . PHE A 1 366 ? 4.586   -21.556 -33.085 1.00 59.05  ? 629  PHE A CZ  1 
ATOM   2549 N  N   . LYS A 1 367 ? 8.581   -19.122 -36.549 1.00 72.36  ? 630  LYS A N   1 
ATOM   2550 C  CA  . LYS A 1 367 ? 9.944   -19.349 -36.014 1.00 75.13  ? 630  LYS A CA  1 
ATOM   2551 C  C   . LYS A 1 367 ? 9.938   -19.088 -34.498 1.00 65.76  ? 630  LYS A C   1 
ATOM   2552 O  O   . LYS A 1 367 ? 10.555  -19.861 -33.769 1.00 62.63  ? 630  LYS A O   1 
ATOM   2553 C  CB  . LYS A 1 367 ? 10.920  -18.464 -36.802 1.00 91.02  ? 630  LYS A CB  1 
ATOM   2554 C  CG  . LYS A 1 367 ? 12.402  -18.816 -36.659 1.00 110.24 ? 630  LYS A CG  1 
ATOM   2555 C  CD  . LYS A 1 367 ? 13.350  -17.996 -37.543 1.00 113.04 ? 630  LYS A CD  1 
ATOM   2556 C  CE  . LYS A 1 367 ? 14.778  -17.946 -37.032 1.00 118.69 ? 630  LYS A CE  1 
ATOM   2557 N  NZ  . LYS A 1 367 ? 14.908  -17.097 -35.821 1.00 125.10 ? 630  LYS A NZ  1 
ATOM   2558 N  N   . SER A 1 368 ? 9.262   -18.046 -34.020 1.00 56.87  ? 631  SER A N   1 
ATOM   2559 C  CA  . SER A 1 368 ? 9.345   -17.626 -32.602 1.00 57.93  ? 631  SER A CA  1 
ATOM   2560 C  C   . SER A 1 368 ? 7.978   -17.248 -32.048 1.00 54.21  ? 631  SER A C   1 
ATOM   2561 O  O   . SER A 1 368 ? 7.247   -16.566 -32.763 1.00 59.56  ? 631  SER A O   1 
ATOM   2562 C  CB  . SER A 1 368 ? 10.265  -16.457 -32.462 1.00 68.60  ? 631  SER A CB  1 
ATOM   2563 O  OG  . SER A 1 368 ? 9.842   -15.620 -31.390 1.00 76.42  ? 631  SER A OG  1 
ATOM   2564 N  N   . ILE A 1 369 ? 7.744   -17.567 -30.772 1.00 54.13  ? 632  ILE A N   1 
ATOM   2565 C  CA  . ILE A 1 369 ? 6.516   -17.224 -29.996 1.00 65.97  ? 632  ILE A CA  1 
ATOM   2566 C  C   . ILE A 1 369 ? 6.596   -15.826 -29.373 1.00 70.86  ? 632  ILE A C   1 
ATOM   2567 O  O   . ILE A 1 369 ? 5.556   -15.322 -28.914 1.00 64.90  ? 632  ILE A O   1 
ATOM   2568 C  CB  . ILE A 1 369 ? 6.251   -18.266 -28.890 1.00 59.54  ? 632  ILE A CB  1 
ATOM   2569 C  CG1 . ILE A 1 369 ? 7.329   -18.252 -27.804 1.00 59.94  ? 632  ILE A CG1 1 
ATOM   2570 C  CG2 . ILE A 1 369 ? 6.081   -19.646 -29.493 1.00 64.70  ? 632  ILE A CG2 1 
ATOM   2571 C  CD1 . ILE A 1 369 ? 6.817   -18.540 -26.427 1.00 58.11  ? 632  ILE A CD1 1 
ATOM   2572 N  N   . GLN A 1 370 ? 7.801   -15.247 -29.318 0.50 78.55  ? 633  GLN A N   1 
ATOM   2573 C  CA  . GLN A 1 370 ? 8.097   -13.959 -28.632 0.50 86.31  ? 633  GLN A CA  1 
ATOM   2574 C  C   . GLN A 1 370 ? 7.319   -12.834 -29.326 0.50 91.98  ? 633  GLN A C   1 
ATOM   2575 O  O   . GLN A 1 370 ? 6.710   -12.008 -28.617 0.50 89.99  ? 633  GLN A O   1 
ATOM   2576 C  CB  . GLN A 1 370 ? 9.603   -13.688 -28.649 0.50 85.49  ? 633  GLN A CB  1 
ATOM   2577 C  CG  . GLN A 1 370 ? 10.121  -13.046 -27.369 0.50 87.57  ? 633  GLN A CG  1 
ATOM   2578 C  CD  . GLN A 1 370 ? 10.237  -14.038 -26.237 0.50 88.11  ? 633  GLN A CD  1 
ATOM   2579 O  OE1 . GLN A 1 370 ? 10.510  -15.218 -26.445 0.50 88.89  ? 633  GLN A OE1 1 
ATOM   2580 N  NE2 . GLN A 1 370 ? 10.032  -13.560 -25.020 0.50 87.32  ? 633  GLN A NE2 1 
ATOM   2581 N  N   . HIS A 1 371 ? 7.339   -12.828 -30.662 0.50 98.88  ? 634  HIS A N   1 
ATOM   2582 C  CA  . HIS A 1 371 ? 6.574   -11.898 -31.534 0.50 104.12 ? 634  HIS A CA  1 
ATOM   2583 C  C   . HIS A 1 371 ? 6.195   -12.616 -32.833 0.50 104.11 ? 634  HIS A C   1 
ATOM   2584 O  O   . HIS A 1 371 ? 7.111   -13.062 -33.554 0.50 99.91  ? 634  HIS A O   1 
ATOM   2585 C  CB  . HIS A 1 371 ? 7.380   -10.623 -31.813 0.50 113.49 ? 634  HIS A CB  1 
ATOM   2586 C  CG  . HIS A 1 371 ? 6.959   -9.913  -33.056 0.50 121.42 ? 634  HIS A CG  1 
ATOM   2587 N  ND1 . HIS A 1 371 ? 5.767   -9.215  -33.143 0.50 124.65 ? 634  HIS A ND1 1 
ATOM   2588 C  CD2 . HIS A 1 371 ? 7.557   -9.795  -34.262 0.50 125.46 ? 634  HIS A CD2 1 
ATOM   2589 C  CE1 . HIS A 1 371 ? 5.652   -8.696  -34.348 0.50 127.84 ? 634  HIS A CE1 1 
ATOM   2590 N  NE2 . HIS A 1 371 ? 6.737   -9.037  -35.055 0.50 129.08 ? 634  HIS A NE2 1 
ATOM   2591 N  N   . LEU A 1 372 ? 4.893   -12.717 -33.112 0.50 107.16 ? 635  LEU A N   1 
ATOM   2592 C  CA  . LEU A 1 372 ? 4.356   -13.275 -34.380 0.50 107.26 ? 635  LEU A CA  1 
ATOM   2593 C  C   . LEU A 1 372 ? 4.363   -12.151 -35.421 0.50 107.13 ? 635  LEU A C   1 
ATOM   2594 O  O   . LEU A 1 372 ? 3.613   -11.169 -35.238 0.50 107.08 ? 635  LEU A O   1 
ATOM   2595 C  CB  . LEU A 1 372 ? 2.949   -13.838 -34.146 0.50 106.89 ? 635  LEU A CB  1 
ATOM   2596 C  CG  . LEU A 1 372 ? 2.399   -14.732 -35.257 0.50 105.54 ? 635  LEU A CG  1 
ATOM   2597 C  CD1 . LEU A 1 372 ? 3.282   -15.953 -35.460 0.50 106.76 ? 635  LEU A CD1 1 
ATOM   2598 C  CD2 . LEU A 1 372 ? 0.971   -15.160 -34.958 0.50 107.01 ? 635  LEU A CD2 1 
ATOM   2599 N  N   . THR A 1 373 ? 5.223   -12.277 -36.436 0.50 106.09 ? 636  THR A N   1 
ATOM   2600 C  CA  . THR A 1 373 ? 5.379   -11.311 -37.555 0.50 107.19 ? 636  THR A CA  1 
ATOM   2601 C  C   . THR A 1 373 ? 4.157   -11.399 -38.474 0.50 109.39 ? 636  THR A C   1 
ATOM   2602 O  O   . THR A 1 373 ? 3.715   -12.530 -38.754 0.50 111.40 ? 636  THR A O   1 
ATOM   2603 C  CB  . THR A 1 373 ? 6.669   -11.582 -38.338 0.50 107.44 ? 636  THR A CB  1 
ATOM   2604 O  OG1 . THR A 1 373 ? 6.452   -12.726 -39.164 0.50 109.65 ? 636  THR A OG1 1 
ATOM   2605 C  CG2 . THR A 1 373 ? 7.864   -11.823 -37.443 0.50 106.07 ? 636  THR A CG2 1 
ATOM   2606 N  N   . VAL A 1 374 ? 3.803   -10.258 -39.081 0.50 113.15 ? 637  VAL A N   1 
ATOM   2607 C  CA  . VAL A 1 374 ? 2.629   -10.164 -40.001 0.50 117.55 ? 637  VAL A CA  1 
ATOM   2608 C  C   . VAL A 1 374 ? 2.801   -11.100 -41.199 0.50 120.33 ? 637  VAL A C   1 
ATOM   2609 O  O   . VAL A 1 374 ? 1.793   -11.685 -41.628 0.50 120.90 ? 637  VAL A O   1 
ATOM   2610 C  CB  . VAL A 1 374 ? 2.431   -8.711  -40.471 0.50 118.20 ? 637  VAL A CB  1 
ATOM   2611 C  CG1 . VAL A 1 374 ? 2.106   -7.786  -39.309 0.50 118.52 ? 637  VAL A CG1 1 
ATOM   2612 C  CG2 . VAL A 1 374 ? 3.638   -8.197  -41.240 0.50 117.57 ? 637  VAL A CG2 1 
ATOM   2613 N  N   . THR A 1 375 ? 4.011   -11.201 -41.747 0.50 122.86 ? 638  THR A N   1 
ATOM   2614 C  CA  . THR A 1 375 ? 4.224   -12.187 -42.836 0.50 125.68 ? 638  THR A CA  1 
ATOM   2615 C  C   . THR A 1 375 ? 3.911   -13.574 -42.270 0.50 121.95 ? 638  THR A C   1 
ATOM   2616 O  O   . THR A 1 375 ? 3.296   -14.381 -42.984 0.50 123.48 ? 638  THR A O   1 
ATOM   2617 C  CB  . THR A 1 375 ? 5.647   -12.103 -43.396 0.50 129.46 ? 638  THR A CB  1 
ATOM   2618 O  OG1 . THR A 1 375 ? 6.556   -12.406 -42.337 0.50 134.07 ? 638  THR A OG1 1 
ATOM   2619 C  CG2 . THR A 1 375 ? 5.970   -10.744 -43.975 0.50 129.73 ? 638  THR A CG2 1 
ATOM   2620 N  N   . GLU A 1 376 ? 4.323   -13.832 -41.028 0.50 116.30 ? 639  GLU A N   1 
ATOM   2621 C  CA  . GLU A 1 376 ? 4.011   -15.130 -40.378 0.50 111.70 ? 639  GLU A CA  1 
ATOM   2622 C  C   . GLU A 1 376 ? 2.504   -15.193 -40.109 0.50 106.52 ? 639  GLU A C   1 
ATOM   2623 O  O   . GLU A 1 376 ? 1.930   -16.282 -40.250 0.50 107.83 ? 639  GLU A O   1 
ATOM   2624 C  CB  . GLU A 1 376 ? 4.840   -15.307 -39.105 0.50 110.15 ? 639  GLU A CB  1 
ATOM   2625 C  CG  . GLU A 1 376 ? 6.248   -15.806 -39.368 0.50 108.91 ? 639  GLU A CG  1 
ATOM   2626 C  CD  . GLU A 1 376 ? 7.147   -15.824 -38.145 0.50 109.99 ? 639  GLU A CD  1 
ATOM   2627 O  OE1 . GLU A 1 376 ? 8.092   -16.635 -38.121 0.50 104.87 ? 639  GLU A OE1 1 
ATOM   2628 O  OE2 . GLU A 1 376 ? 6.905   -15.021 -37.225 0.50 115.21 ? 639  GLU A OE2 1 
ATOM   2629 N  N   . GLU A 1 377 ? 1.895   -14.057 -39.761 0.50 99.52  ? 640  GLU A N   1 
ATOM   2630 C  CA  . GLU A 1 377 ? 0.431   -14.024 -39.511 0.50 96.16  ? 640  GLU A CA  1 
ATOM   2631 C  C   . GLU A 1 377 ? -0.297  -14.514 -40.764 0.50 93.88  ? 640  GLU A C   1 
ATOM   2632 O  O   . GLU A 1 377 ? -1.155  -15.402 -40.633 0.50 104.25 ? 640  GLU A O   1 
ATOM   2633 C  CB  . GLU A 1 377 ? -0.032  -12.623 -39.116 0.50 94.28  ? 640  GLU A CB  1 
ATOM   2634 C  CG  . GLU A 1 377 ? 0.523   -12.159 -37.783 0.50 95.89  ? 640  GLU A CG  1 
ATOM   2635 C  CD  . GLU A 1 377 ? -0.010  -10.812 -37.329 0.50 97.72  ? 640  GLU A CD  1 
ATOM   2636 O  OE1 . GLU A 1 377 ? -0.893  -10.270 -38.018 0.50 101.05 ? 640  GLU A OE1 1 
ATOM   2637 O  OE2 . GLU A 1 377 ? 0.457   -10.311 -36.289 0.50 95.25  ? 640  GLU A OE2 1 
ATOM   2638 N  N   . ILE A 1 378 ? 0.048   -13.970 -41.931 0.50 87.49  ? 641  ILE A N   1 
ATOM   2639 C  CA  . ILE A 1 378 ? -0.667  -14.366 -43.180 0.50 86.06  ? 641  ILE A CA  1 
ATOM   2640 C  C   . ILE A 1 378 ? -0.364  -15.839 -43.452 0.50 77.90  ? 641  ILE A C   1 
ATOM   2641 O  O   . ILE A 1 378 ? -1.286  -16.561 -43.852 0.50 80.99  ? 641  ILE A O   1 
ATOM   2642 C  CB  . ILE A 1 378 ? -0.294  -13.469 -44.379 0.50 89.52  ? 641  ILE A CB  1 
ATOM   2643 C  CG1 . ILE A 1 378 ? -1.060  -13.876 -45.640 0.50 90.37  ? 641  ILE A CG1 1 
ATOM   2644 C  CG2 . ILE A 1 378 ? 1.205   -13.459 -44.618 0.50 89.61  ? 641  ILE A CG2 1 
ATOM   2645 C  CD1 . ILE A 1 378 ? -0.649  -13.119 -46.878 0.50 92.05  ? 641  ILE A CD1 1 
ATOM   2646 N  N   . ALA A 1 379 ? 0.884   -16.256 -43.232 0.50 70.68  ? 642  ALA A N   1 
ATOM   2647 C  CA  . ALA A 1 379 ? 1.275   -17.661 -43.485 0.50 68.14  ? 642  ALA A CA  1 
ATOM   2648 C  C   . ALA A 1 379 ? 0.446   -18.589 -42.593 0.50 61.65  ? 642  ALA A C   1 
ATOM   2649 O  O   . ALA A 1 379 ? -0.029  -19.620 -43.093 0.50 57.20  ? 642  ALA A O   1 
ATOM   2650 C  CB  . ALA A 1 379 ? 2.750   -17.826 -43.231 0.50 65.71  ? 642  ALA A CB  1 
ATOM   2651 N  N   . VAL A 1 380 ? 0.287   -18.223 -41.323 1.00 54.41  ? 643  VAL A N   1 
ATOM   2652 C  CA  . VAL A 1 380 ? -0.524  -19.032 -40.375 1.00 56.12  ? 643  VAL A CA  1 
ATOM   2653 C  C   . VAL A 1 380 ? -1.950  -19.111 -40.921 1.00 59.50  ? 643  VAL A C   1 
ATOM   2654 O  O   . VAL A 1 380 ? -2.486  -20.223 -41.006 1.00 51.42  ? 643  VAL A O   1 
ATOM   2655 C  CB  . VAL A 1 380 ? -0.489  -18.426 -38.962 1.00 53.15  ? 643  VAL A CB  1 
ATOM   2656 C  CG1 . VAL A 1 380 ? -1.629  -18.937 -38.097 1.00 54.25  ? 643  VAL A CG1 1 
ATOM   2657 C  CG2 . VAL A 1 380 ? 0.851   -18.657 -38.284 1.00 54.02  ? 643  VAL A CG2 1 
ATOM   2658 N  N   . LYS A 1 381 ? -2.509  -17.967 -41.319 0.50 58.76  ? 644  LYS A N   1 
ATOM   2659 C  CA  . LYS A 1 381 ? -3.894  -17.930 -41.851 0.50 58.97  ? 644  LYS A CA  1 
ATOM   2660 C  C   . LYS A 1 381 ? -3.960  -18.774 -43.126 0.50 56.17  ? 644  LYS A C   1 
ATOM   2661 O  O   . LYS A 1 381 ? -4.948  -19.513 -43.289 0.50 55.01  ? 644  LYS A O   1 
ATOM   2662 C  CB  . LYS A 1 381 ? -4.316  -16.478 -42.092 0.50 62.19  ? 644  LYS A CB  1 
ATOM   2663 C  CG  . LYS A 1 381 ? -4.272  -15.589 -40.858 0.50 66.61  ? 644  LYS A CG  1 
ATOM   2664 C  CD  . LYS A 1 381 ? -4.453  -14.119 -41.157 0.50 70.02  ? 644  LYS A CD  1 
ATOM   2665 C  CE  . LYS A 1 381 ? -4.333  -13.252 -39.922 0.50 72.40  ? 644  LYS A CE  1 
ATOM   2666 N  NZ  . LYS A 1 381 ? -4.508  -11.816 -40.240 0.50 77.76  ? 644  LYS A NZ  1 
ATOM   2667 N  N   . ASN A 1 382 ? -2.936  -18.683 -43.976 0.50 51.43  ? 645  ASN A N   1 
ATOM   2668 C  CA  . ASN A 1 382 ? -2.924  -19.430 -45.261 0.50 52.35  ? 645  ASN A CA  1 
ATOM   2669 C  C   . ASN A 1 382 ? -2.829  -20.927 -44.963 0.50 50.89  ? 645  ASN A C   1 
ATOM   2670 O  O   . ASN A 1 382 ? -3.459  -21.715 -45.689 0.50 48.27  ? 645  ASN A O   1 
ATOM   2671 C  CB  . ASN A 1 382 ? -1.802  -18.944 -46.178 0.50 55.85  ? 645  ASN A CB  1 
ATOM   2672 C  CG  . ASN A 1 382 ? -1.953  -17.496 -46.596 0.50 59.78  ? 645  ASN A CG  1 
ATOM   2673 O  OD1 . ASN A 1 382 ? -1.127  -16.972 -47.339 0.50 58.43  ? 645  ASN A OD1 1 
ATOM   2674 N  ND2 . ASN A 1 382 ? -3.001  -16.841 -46.127 0.50 61.85  ? 645  ASN A ND2 1 
ATOM   2675 N  N   . TRP A 1 383 ? -2.068  -21.294 -43.932 1.00 51.53  ? 646  TRP A N   1 
ATOM   2676 C  CA  . TRP A 1 383 ? -1.949  -22.715 -43.516 1.00 47.91  ? 646  TRP A CA  1 
ATOM   2677 C  C   . TRP A 1 383 ? -3.324  -23.223 -43.084 1.00 43.46  ? 646  TRP A C   1 
ATOM   2678 O  O   . TRP A 1 383 ? -3.760  -24.249 -43.609 1.00 39.34  ? 646  TRP A O   1 
ATOM   2679 C  CB  . TRP A 1 383 ? -0.914  -22.815 -42.393 1.00 46.73  ? 646  TRP A CB  1 
ATOM   2680 C  CG  . TRP A 1 383 ? -0.536  -24.192 -41.948 1.00 49.39  ? 646  TRP A CG  1 
ATOM   2681 C  CD1 . TRP A 1 383 ? 0.412   -25.005 -42.496 1.00 52.61  ? 646  TRP A CD1 1 
ATOM   2682 C  CD2 . TRP A 1 383 ? -1.059  -24.900 -40.812 1.00 50.84  ? 646  TRP A CD2 1 
ATOM   2683 N  NE1 . TRP A 1 383 ? 0.497   -26.176 -41.796 1.00 50.75  ? 646  TRP A NE1 1 
ATOM   2684 C  CE2 . TRP A 1 383 ? -0.393  -26.141 -40.757 1.00 50.98  ? 646  TRP A CE2 1 
ATOM   2685 C  CE3 . TRP A 1 383 ? -2.030  -24.612 -39.849 1.00 47.57  ? 646  TRP A CE3 1 
ATOM   2686 C  CZ2 . TRP A 1 383 ? -0.670  -27.089 -39.776 1.00 45.12  ? 646  TRP A CZ2 1 
ATOM   2687 C  CZ3 . TRP A 1 383 ? -2.303  -25.550 -38.880 1.00 47.28  ? 646  TRP A CZ3 1 
ATOM   2688 C  CH2 . TRP A 1 383 ? -1.630  -26.770 -38.846 1.00 44.90  ? 646  TRP A CH2 1 
ATOM   2689 N  N   . LEU A 1 384 ? -3.995  -22.476 -42.211 0.50 42.09  ? 647  LEU A N   1 
ATOM   2690 C  CA  . LEU A 1 384 ? -5.323  -22.892 -41.699 0.50 45.34  ? 647  LEU A CA  1 
ATOM   2691 C  C   . LEU A 1 384 ? -6.307  -23.060 -42.859 0.50 48.87  ? 647  LEU A C   1 
ATOM   2692 O  O   . LEU A 1 384 ? -7.065  -24.036 -42.840 0.50 46.88  ? 647  LEU A O   1 
ATOM   2693 C  CB  . LEU A 1 384 ? -5.805  -21.823 -40.717 0.50 42.65  ? 647  LEU A CB  1 
ATOM   2694 C  CG  . LEU A 1 384 ? -5.116  -21.828 -39.354 0.50 43.91  ? 647  LEU A CG  1 
ATOM   2695 C  CD1 . LEU A 1 384 ? -5.499  -20.600 -38.546 0.50 43.74  ? 647  LEU A CD1 1 
ATOM   2696 C  CD2 . LEU A 1 384 ? -5.448  -23.098 -38.587 0.50 42.76  ? 647  LEU A CD2 1 
ATOM   2697 N  N   . VAL A 1 385 ? -6.277  -22.157 -43.840 0.50 53.84  ? 648  VAL A N   1 
ATOM   2698 C  CA  . VAL A 1 385 ? -7.283  -22.191 -44.941 0.50 52.49  ? 648  VAL A CA  1 
ATOM   2699 C  C   . VAL A 1 385 ? -6.970  -23.324 -45.918 0.50 52.26  ? 648  VAL A C   1 
ATOM   2700 O  O   . VAL A 1 385 ? -7.923  -23.893 -46.471 0.50 55.69  ? 648  VAL A O   1 
ATOM   2701 C  CB  . VAL A 1 385 ? -7.327  -20.834 -45.669 0.50 56.39  ? 648  VAL A CB  1 
ATOM   2702 C  CG1 . VAL A 1 385 ? -8.042  -20.921 -47.007 0.50 55.68  ? 648  VAL A CG1 1 
ATOM   2703 C  CG2 . VAL A 1 385 ? -7.940  -19.749 -44.797 0.50 58.36  ? 648  VAL A CG2 1 
ATOM   2704 N  N   . ARG A 1 386 ? -5.698  -23.663 -46.095 0.50 52.43  ? 649  ARG A N   1 
ATOM   2705 C  CA  . ARG A 1 386 ? -5.325  -24.652 -47.142 0.50 54.05  ? 649  ARG A CA  1 
ATOM   2706 C  C   . ARG A 1 386 ? -5.255  -26.071 -46.549 0.50 53.29  ? 649  ARG A C   1 
ATOM   2707 O  O   . ARG A 1 386 ? -5.628  -27.019 -47.280 0.50 52.61  ? 649  ARG A O   1 
ATOM   2708 C  CB  . ARG A 1 386 ? -4.048  -24.185 -47.855 0.50 59.95  ? 649  ARG A CB  1 
ATOM   2709 C  CG  . ARG A 1 386 ? -2.918  -25.204 -47.927 0.50 66.41  ? 649  ARG A CG  1 
ATOM   2710 C  CD  . ARG A 1 386 ? -1.626  -24.584 -48.455 0.50 69.06  ? 649  ARG A CD  1 
ATOM   2711 N  NE  . ARG A 1 386 ? -0.428  -25.048 -47.755 0.50 69.05  ? 649  ARG A NE  1 
ATOM   2712 C  CZ  . ARG A 1 386 ? 0.308   -24.303 -46.928 0.50 70.15  ? 649  ARG A CZ  1 
ATOM   2713 N  NH1 . ARG A 1 386 ? -0.012  -23.040 -46.699 0.50 70.48  ? 649  ARG A NH1 1 
ATOM   2714 N  NH2 . ARG A 1 386 ? 1.366   -24.826 -46.331 0.50 69.57  ? 649  ARG A NH2 1 
ATOM   2715 N  N   . VAL A 1 387 ? -4.822  -26.241 -45.291 0.50 49.89  ? 650  VAL A N   1 
ATOM   2716 C  CA  . VAL A 1 387 ? -4.591  -27.600 -44.704 0.50 50.49  ? 650  VAL A CA  1 
ATOM   2717 C  C   . VAL A 1 387 ? -5.247  -27.713 -43.321 0.50 47.07  ? 650  VAL A C   1 
ATOM   2718 O  O   . VAL A 1 387 ? -5.175  -28.810 -42.736 0.50 46.11  ? 650  VAL A O   1 
ATOM   2719 C  CB  . VAL A 1 387 ? -3.093  -27.965 -44.627 0.50 48.31  ? 650  VAL A CB  1 
ATOM   2720 C  CG1 . VAL A 1 387 ? -2.458  -28.053 -46.003 0.50 47.98  ? 650  VAL A CG1 1 
ATOM   2721 C  CG2 . VAL A 1 387 ? -2.313  -27.014 -43.733 0.50 48.23  ? 650  VAL A CG2 1 
ATOM   2722 N  N   . GLY A 1 388 ? -5.857  -26.638 -42.822 0.50 45.21  ? 651  GLY A N   1 
ATOM   2723 C  CA  . GLY A 1 388 ? -6.493  -26.610 -41.490 0.50 45.05  ? 651  GLY A CA  1 
ATOM   2724 C  C   . GLY A 1 388 ? -7.324  -27.860 -41.244 0.50 45.56  ? 651  GLY A C   1 
ATOM   2725 O  O   . GLY A 1 388 ? -7.083  -28.559 -40.241 0.50 45.27  ? 651  GLY A O   1 
ATOM   2726 N  N   . ARG A 1 389 ? -8.263  -28.147 -42.142 0.50 44.61  ? 652  ARG A N   1 
ATOM   2727 C  CA  . ARG A 1 389 ? -9.223  -29.273 -42.010 0.50 45.03  ? 652  ARG A CA  1 
ATOM   2728 C  C   . ARG A 1 389 ? -8.444  -30.591 -42.061 0.50 43.98  ? 652  ARG A C   1 
ATOM   2729 O  O   . ARG A 1 389 ? -8.768  -31.491 -41.261 0.50 46.25  ? 652  ARG A O   1 
ATOM   2730 C  CB  . ARG A 1 389 ? -10.307 -29.163 -43.089 0.50 44.25  ? 652  ARG A CB  1 
ATOM   2731 C  CG  . ARG A 1 389 ? -11.212 -27.950 -42.912 0.50 45.65  ? 652  ARG A CG  1 
ATOM   2732 C  CD  . ARG A 1 389 ? -12.281 -27.823 -43.987 0.50 46.44  ? 652  ARG A CD  1 
ATOM   2733 N  NE  . ARG A 1 389 ? -13.157 -28.981 -44.043 0.50 46.98  ? 652  ARG A NE  1 
ATOM   2734 C  CZ  . ARG A 1 389 ? -14.214 -29.158 -43.257 0.50 49.52  ? 652  ARG A CZ  1 
ATOM   2735 N  NH1 . ARG A 1 389 ? -14.529 -28.249 -42.346 0.50 50.96  ? 652  ARG A NH1 1 
ATOM   2736 N  NH2 . ARG A 1 389 ? -14.944 -30.251 -43.375 0.50 48.91  ? 652  ARG A NH2 1 
ATOM   2737 N  N   . GLU A 1 390 ? -7.452  -30.702 -42.951 1.00 40.47  ? 653  GLU A N   1 
ATOM   2738 C  CA  . GLU A 1 390 ? -6.604  -31.930 -43.039 1.00 44.00  ? 653  GLU A CA  1 
ATOM   2739 C  C   . GLU A 1 390 ? -5.868  -32.164 -41.696 1.00 39.53  ? 653  GLU A C   1 
ATOM   2740 O  O   . GLU A 1 390 ? -5.871  -33.299 -41.225 1.00 37.91  ? 653  GLU A O   1 
ATOM   2741 C  CB  . GLU A 1 390 ? -5.611  -31.908 -44.193 1.00 42.11  ? 653  GLU A CB  1 
ATOM   2742 C  CG  . GLU A 1 390 ? -5.139  -33.320 -44.553 1.00 44.72  ? 653  GLU A CG  1 
ATOM   2743 C  CD  . GLU A 1 390 ? -3.938  -33.872 -43.771 1.00 46.04  ? 653  GLU A CD  1 
ATOM   2744 O  OE1 . GLU A 1 390 ? -3.345  -33.136 -42.935 1.00 38.22  ? 653  GLU A OE1 1 
ATOM   2745 O  OE2 . GLU A 1 390 ? -3.589  -35.050 -43.995 1.00 51.56  ? 653  GLU A OE2 1 
ATOM   2746 N  N   . ARG A 1 391 ? -5.388  -31.112 -41.034 1.00 35.47  ? 654  ARG A N   1 
ATOM   2747 C  CA  . ARG A 1 391 ? -4.637  -31.247 -39.771 1.00 38.13  ? 654  ARG A CA  1 
ATOM   2748 C  C   . ARG A 1 391 ? -5.607  -31.585 -38.641 1.00 35.04  ? 654  ARG A C   1 
ATOM   2749 O  O   . ARG A 1 391 ? -5.207  -32.291 -37.729 1.00 33.89  ? 654  ARG A O   1 
ATOM   2750 C  CB  . ARG A 1 391 ? -3.804  -29.990 -39.516 1.00 42.40  ? 654  ARG A CB  1 
ATOM   2751 C  CG  . ARG A 1 391 ? -2.812  -29.696 -40.645 1.00 42.56  ? 654  ARG A CG  1 
ATOM   2752 C  CD  . ARG A 1 391 ? -1.710  -30.738 -40.779 1.00 43.27  ? 654  ARG A CD  1 
ATOM   2753 N  NE  . ARG A 1 391 ? -0.664  -30.237 -41.645 1.00 45.26  ? 654  ARG A NE  1 
ATOM   2754 C  CZ  . ARG A 1 391 ? -0.589  -30.410 -42.974 1.00 48.30  ? 654  ARG A CZ  1 
ATOM   2755 N  NH1 . ARG A 1 391 ? -1.463  -31.130 -43.649 1.00 46.47  ? 654  ARG A NH1 1 
ATOM   2756 N  NH2 . ARG A 1 391 ? 0.414   -29.887 -43.641 1.00 53.92  ? 654  ARG A NH2 1 
ATOM   2757 N  N   . LEU A 1 392 ? -6.843  -31.106 -38.701 1.00 34.78  ? 655  LEU A N   1 
ATOM   2758 C  CA  . LEU A 1 392 ? -7.879  -31.437 -37.677 1.00 36.80  ? 655  LEU A CA  1 
ATOM   2759 C  C   . LEU A 1 392 ? -8.219  -32.931 -37.779 1.00 33.57  ? 655  LEU A C   1 
ATOM   2760 O  O   . LEU A 1 392 ? -8.362  -33.574 -36.744 1.00 31.73  ? 655  LEU A O   1 
ATOM   2761 C  CB  . LEU A 1 392 ? -9.118  -30.563 -37.870 1.00 40.13  ? 655  LEU A CB  1 
ATOM   2762 C  CG  . LEU A 1 392 ? -8.998  -29.108 -37.432 1.00 40.81  ? 655  LEU A CG  1 
ATOM   2763 C  CD1 . LEU A 1 392 ? -10.306 -28.379 -37.752 1.00 44.50  ? 655  LEU A CD1 1 
ATOM   2764 C  CD2 . LEU A 1 392 ? -8.650  -28.997 -35.949 1.00 37.20  ? 655  LEU A CD2 1 
ATOM   2765 N  N   . SER A 1 393 ? -8.254  -33.481 -38.986 1.00 30.86  ? 656  SER A N   1 
ATOM   2766 C  CA  . SER A 1 393 ? -8.575  -34.903 -39.230 1.00 33.95  ? 656  SER A CA  1 
ATOM   2767 C  C   . SER A 1 393 ? -7.481  -35.843 -38.736 1.00 36.38  ? 656  SER A C   1 
ATOM   2768 O  O   . SER A 1 393 ? -7.767  -37.040 -38.670 1.00 32.84  ? 656  SER A O   1 
ATOM   2769 C  CB  . SER A 1 393 ? -8.864  -35.134 -40.692 1.00 41.17  ? 656  SER A CB  1 
ATOM   2770 O  OG  . SER A 1 393 ? -7.683  -35.016 -41.474 1.00 49.46  ? 656  SER A OG  1 
ATOM   2771 N  N   . ARG A 1 394 ? -6.294  -35.315 -38.379 1.00 35.91  ? 657  ARG A N   1 
ATOM   2772 C  CA  . ARG A 1 394 ? -5.117  -36.069 -37.896 1.00 38.60  ? 657  ARG A CA  1 
ATOM   2773 C  C   . ARG A 1 394 ? -5.189  -36.248 -36.382 1.00 34.42  ? 657  ARG A C   1 
ATOM   2774 O  O   . ARG A 1 394 ? -4.220  -36.764 -35.791 1.00 34.36  ? 657  ARG A O   1 
ATOM   2775 C  CB  . ARG A 1 394 ? -3.836  -35.283 -38.203 1.00 37.47  ? 657  ARG A CB  1 
ATOM   2776 C  CG  . ARG A 1 394 ? -3.481  -35.299 -39.673 1.00 40.67  ? 657  ARG A CG  1 
ATOM   2777 C  CD  . ARG A 1 394 ? -2.173  -34.567 -39.948 1.00 42.10  ? 657  ARG A CD  1 
ATOM   2778 N  NE  . ARG A 1 394 ? -1.795  -35.065 -41.246 1.00 41.92  ? 657  ARG A NE  1 
ATOM   2779 C  CZ  . ARG A 1 394 ? -1.087  -36.157 -41.474 1.00 46.12  ? 657  ARG A CZ  1 
ATOM   2780 N  NH1 . ARG A 1 394 ? -0.576  -36.880 -40.484 1.00 43.60  ? 657  ARG A NH1 1 
ATOM   2781 N  NH2 . ARG A 1 394 ? -0.856  -36.511 -42.722 1.00 49.72  ? 657  ARG A NH2 1 
ATOM   2782 N  N   . MET A 1 395 ? -6.252  -35.765 -35.773 1.00 32.83  ? 658  MET A N   1 
ATOM   2783 C  CA  . MET A 1 395 ? -6.422  -35.768 -34.299 1.00 34.25  ? 658  MET A CA  1 
ATOM   2784 C  C   . MET A 1 395 ? -7.764  -36.390 -33.865 1.00 32.12  ? 658  MET A C   1 
ATOM   2785 O  O   . MET A 1 395 ? -8.721  -36.329 -34.596 1.00 28.50  ? 658  MET A O   1 
ATOM   2786 C  CB  . MET A 1 395 ? -6.286  -34.333 -33.786 1.00 34.88  ? 658  MET A CB  1 
ATOM   2787 C  CG  . MET A 1 395 ? -5.054  -33.622 -34.320 1.00 36.83  ? 658  MET A CG  1 
ATOM   2788 S  SD  . MET A 1 395 ? -4.754  -32.050 -33.470 1.00 36.58  ? 658  MET A SD  1 
ATOM   2789 C  CE  . MET A 1 395 ? -5.945  -30.932 -34.193 1.00 41.19  ? 658  MET A CE  1 
ATOM   2790 N  N   . ALA A 1 396 ? -7.766  -36.988 -32.679 1.00 31.73  ? 659  ALA A N   1 
ATOM   2791 C  CA  . ALA A 1 396 ? -8.919  -37.382 -31.871 1.00 32.59  ? 659  ALA A CA  1 
ATOM   2792 C  C   . ALA A 1 396 ? -8.802  -36.650 -30.525 1.00 31.69  ? 659  ALA A C   1 
ATOM   2793 O  O   . ALA A 1 396 ? -7.867  -36.912 -29.794 1.00 29.67  ? 659  ALA A O   1 
ATOM   2794 C  CB  . ALA A 1 396 ? -8.926  -38.878 -31.700 1.00 35.40  ? 659  ALA A CB  1 
ATOM   2795 N  N   . ILE A 1 397 ? -9.766  -35.801 -30.207 1.00 31.13  ? 660  ILE A N   1 
ATOM   2796 C  CA  . ILE A 1 397 ? -9.726  -34.888 -29.049 1.00 30.04  ? 660  ILE A CA  1 
ATOM   2797 C  C   . ILE A 1 397 ? -11.051 -35.026 -28.295 1.00 35.14  ? 660  ILE A C   1 
ATOM   2798 O  O   . ILE A 1 397 ? -12.133 -34.837 -28.893 1.00 30.24  ? 660  ILE A O   1 
ATOM   2799 C  CB  . ILE A 1 397 ? -9.433  -33.452 -29.512 1.00 31.81  ? 660  ILE A CB  1 
ATOM   2800 C  CG1 . ILE A 1 397 ? -8.119  -33.439 -30.315 1.00 39.97  ? 660  ILE A CG1 1 
ATOM   2801 C  CG2 . ILE A 1 397 ? -9.440  -32.545 -28.298 1.00 31.75  ? 660  ILE A CG2 1 
ATOM   2802 C  CD1 . ILE A 1 397 ? -7.460  -32.109 -30.569 1.00 38.52  ? 660  ILE A CD1 1 
ATOM   2803 N  N   . SER A 1 398 ? -10.938 -35.339 -27.011 1.00 31.19  ? 661  SER A N   1 
ATOM   2804 C  CA  . SER A 1 398 ? -12.045 -35.503 -26.079 1.00 34.70  ? 661  SER A CA  1 
ATOM   2805 C  C   . SER A 1 398 ? -11.740 -34.649 -24.877 1.00 34.48  ? 661  SER A C   1 
ATOM   2806 O  O   . SER A 1 398 ? -10.996 -35.142 -24.020 1.00 33.49  ? 661  SER A O   1 
ATOM   2807 C  CB  . SER A 1 398 ? -12.226 -36.951 -25.693 1.00 37.33  ? 661  SER A CB  1 
ATOM   2808 O  OG  . SER A 1 398 ? -13.514 -37.094 -25.125 1.00 32.44  ? 661  SER A OG  1 
ATOM   2809 N  N   . GLY A 1 399 ? -12.261 -33.424 -24.830 1.00 30.55  ? 662  GLY A N   1 
ATOM   2810 C  CA  . GLY A 1 399 ? -11.884 -32.531 -23.715 1.00 30.65  ? 662  GLY A CA  1 
ATOM   2811 C  C   . GLY A 1 399 ? -10.372 -32.345 -23.643 1.00 32.11  ? 662  GLY A C   1 
ATOM   2812 O  O   . GLY A 1 399 ? -9.758  -32.031 -24.693 1.00 31.32  ? 662  GLY A O   1 
ATOM   2813 N  N   . ASP A 1 400 ? -9.777  -32.539 -22.465 1.00 32.82  ? 663  ASP A N   1 
ATOM   2814 C  CA  . ASP A 1 400 ? -8.317  -32.373 -22.263 1.00 37.76  ? 663  ASP A CA  1 
ATOM   2815 C  C   . ASP A 1 400 ? -7.567  -33.570 -22.839 1.00 35.01  ? 663  ASP A C   1 
ATOM   2816 O  O   . ASP A 1 400 ? -6.337  -33.539 -22.833 1.00 39.53  ? 663  ASP A O   1 
ATOM   2817 C  CB  . ASP A 1 400 ? -7.975  -32.138 -20.789 1.00 43.17  ? 663  ASP A CB  1 
ATOM   2818 C  CG  . ASP A 1 400 ? -8.209  -33.334 -19.888 1.00 45.11  ? 663  ASP A CG  1 
ATOM   2819 O  OD1 . ASP A 1 400 ? -9.003  -34.209 -20.256 1.00 47.54  ? 663  ASP A OD1 1 
ATOM   2820 O  OD2 . ASP A 1 400 ? -7.596  -33.363 -18.822 1.00 56.28  ? 663  ASP A OD2 1 
ATOM   2821 N  N   . ASP A 1 401 ? -8.248  -34.566 -23.377 1.00 33.01  ? 664  ASP A N   1 
ATOM   2822 C  CA  . ASP A 1 401 ? -7.560  -35.797 -23.842 1.00 34.60  ? 664  ASP A CA  1 
ATOM   2823 C  C   . ASP A 1 401 ? -7.328  -35.695 -25.346 1.00 35.52  ? 664  ASP A C   1 
ATOM   2824 O  O   . ASP A 1 401 ? -8.255  -35.282 -26.032 1.00 34.94  ? 664  ASP A O   1 
ATOM   2825 C  CB  . ASP A 1 401 ? -8.357  -37.049 -23.490 1.00 36.87  ? 664  ASP A CB  1 
ATOM   2826 C  CG  . ASP A 1 401 ? -7.434  -38.238 -23.391 1.00 40.99  ? 664  ASP A CG  1 
ATOM   2827 O  OD1 . ASP A 1 401 ? -6.253  -37.983 -23.435 1.00 40.02  ? 664  ASP A OD1 1 
ATOM   2828 O  OD2 . ASP A 1 401 ? -7.893  -39.374 -23.298 1.00 47.27  ? 664  ASP A OD2 1 
ATOM   2829 N  N   . CYS A 1 402 ? -6.129  -36.017 -25.840 1.00 31.50  ? 665  CYS A N   1 
ATOM   2830 C  CA  . CYS A 1 402 ? -5.853  -36.002 -27.298 1.00 31.90  ? 665  CYS A CA  1 
ATOM   2831 C  C   . CYS A 1 402 ? -4.900  -37.115 -27.744 1.00 33.80  ? 665  CYS A C   1 
ATOM   2832 O  O   . CYS A 1 402 ? -3.987  -37.522 -26.994 1.00 33.85  ? 665  CYS A O   1 
ATOM   2833 C  CB  . CYS A 1 402 ? -5.264  -34.663 -27.738 1.00 36.24  ? 665  CYS A CB  1 
ATOM   2834 S  SG  . CYS A 1 402 ? -3.600  -34.328 -27.082 1.00 40.93  ? 665  CYS A SG  1 
ATOM   2835 N  N   . VAL A 1 403 ? -5.049  -37.438 -29.025 1.00 32.22  ? 666  VAL A N   1 
ATOM   2836 C  CA  . VAL A 1 403 ? -4.139  -38.256 -29.852 1.00 30.49  ? 666  VAL A CA  1 
ATOM   2837 C  C   . VAL A 1 403 ? -3.889  -37.449 -31.130 1.00 34.48  ? 666  VAL A C   1 
ATOM   2838 O  O   . VAL A 1 403 ? -4.849  -36.977 -31.717 1.00 30.79  ? 666  VAL A O   1 
ATOM   2839 C  CB  . VAL A 1 403 ? -4.750  -39.640 -30.114 1.00 29.90  ? 666  VAL A CB  1 
ATOM   2840 C  CG1 . VAL A 1 403 ? -3.888  -40.456 -31.067 1.00 31.58  ? 666  VAL A CG1 1 
ATOM   2841 C  CG2 . VAL A 1 403 ? -4.998  -40.398 -28.799 1.00 28.13  ? 666  VAL A CG2 1 
ATOM   2842 N  N   . VAL A 1 404 ? -2.627  -37.213 -31.498 1.00 32.26  ? 667  VAL A N   1 
ATOM   2843 C  CA  . VAL A 1 404 ? -2.253  -36.457 -32.728 1.00 30.87  ? 667  VAL A CA  1 
ATOM   2844 C  C   . VAL A 1 404 ? -1.319  -37.333 -33.547 1.00 32.26  ? 667  VAL A C   1 
ATOM   2845 O  O   . VAL A 1 404 ? -0.363  -37.876 -32.989 1.00 31.80  ? 667  VAL A O   1 
ATOM   2846 C  CB  . VAL A 1 404 ? -1.565  -35.120 -32.422 1.00 30.99  ? 667  VAL A CB  1 
ATOM   2847 C  CG1 . VAL A 1 404 ? -1.323  -34.336 -33.692 1.00 30.40  ? 667  VAL A CG1 1 
ATOM   2848 C  CG2 . VAL A 1 404 ? -2.328  -34.280 -31.423 1.00 34.90  ? 667  VAL A CG2 1 
ATOM   2849 N  N   . LYS A 1 405 ? -1.602  -37.459 -34.826 1.00 30.39  ? 668  LYS A N   1 
ATOM   2850 C  CA  . LYS A 1 405 ? -0.672  -38.080 -35.772 1.00 32.67  ? 668  LYS A CA  1 
ATOM   2851 C  C   . LYS A 1 405 ? -0.186  -36.982 -36.699 1.00 34.95  ? 668  LYS A C   1 
ATOM   2852 O  O   . LYS A 1 405 ? -0.821  -36.735 -37.733 1.00 32.46  ? 668  LYS A O   1 
ATOM   2853 C  CB  . LYS A 1 405 ? -1.301  -39.206 -36.577 1.00 33.47  ? 668  LYS A CB  1 
ATOM   2854 C  CG  . LYS A 1 405 ? -0.321  -39.732 -37.601 1.00 36.44  ? 668  LYS A CG  1 
ATOM   2855 C  CD  . LYS A 1 405 ? -0.617  -41.071 -38.180 1.00 39.29  ? 668  LYS A CD  1 
ATOM   2856 C  CE  . LYS A 1 405 ? 0.607   -41.572 -38.927 1.00 43.89  ? 668  LYS A CE  1 
ATOM   2857 N  NZ  . LYS A 1 405 ? 0.519   -43.018 -39.190 1.00 44.97  ? 668  LYS A NZ  1 
ATOM   2858 N  N   . PRO A 1 406 ? 0.934   -36.295 -36.348 1.00 37.30  ? 669  PRO A N   1 
ATOM   2859 C  CA  . PRO A 1 406 ? 1.398   -35.149 -37.129 1.00 37.26  ? 669  PRO A CA  1 
ATOM   2860 C  C   . PRO A 1 406 ? 2.019   -35.591 -38.451 1.00 33.38  ? 669  PRO A C   1 
ATOM   2861 O  O   . PRO A 1 406 ? 2.246   -36.798 -38.693 1.00 34.86  ? 669  PRO A O   1 
ATOM   2862 C  CB  . PRO A 1 406 ? 2.378   -34.432 -36.217 1.00 36.98  ? 669  PRO A CB  1 
ATOM   2863 C  CG  . PRO A 1 406 ? 2.910   -35.572 -35.381 1.00 45.53  ? 669  PRO A CG  1 
ATOM   2864 C  CD  . PRO A 1 406 ? 1.735   -36.495 -35.149 1.00 36.61  ? 669  PRO A CD  1 
ATOM   2865 N  N   . LEU A 1 407 ? 2.272   -34.607 -39.299 1.00 38.00  ? 670  LEU A N   1 
ATOM   2866 C  CA  . LEU A 1 407 ? 2.939   -34.830 -40.613 1.00 41.37  ? 670  LEU A CA  1 
ATOM   2867 C  C   . LEU A 1 407 ? 4.247   -35.633 -40.452 1.00 42.75  ? 670  LEU A C   1 
ATOM   2868 O  O   . LEU A 1 407 ? 4.527   -36.456 -41.370 1.00 38.46  ? 670  LEU A O   1 
ATOM   2869 C  CB  . LEU A 1 407 ? 3.198   -33.471 -41.250 1.00 46.48  ? 670  LEU A CB  1 
ATOM   2870 C  CG  . LEU A 1 407 ? 3.013   -33.427 -42.754 1.00 56.52  ? 670  LEU A CG  1 
ATOM   2871 C  CD1 . LEU A 1 407 ? 1.607   -33.858 -43.126 1.00 54.68  ? 670  LEU A CD1 1 
ATOM   2872 C  CD2 . LEU A 1 407 ? 3.324   -32.021 -43.264 1.00 65.00  ? 670  LEU A CD2 1 
ATOM   2873 N  N   . ASP A 1 408 ? 5.007   -35.431 -39.355 1.00 39.88  ? 671  ASP A N   1 
ATOM   2874 C  CA  . ASP A 1 408 ? 6.337   -36.091 -39.115 1.00 44.46  ? 671  ASP A CA  1 
ATOM   2875 C  C   . ASP A 1 408 ? 6.764   -35.891 -37.655 1.00 40.40  ? 671  ASP A C   1 
ATOM   2876 O  O   . ASP A 1 408 ? 6.050   -35.217 -36.915 1.00 40.09  ? 671  ASP A O   1 
ATOM   2877 C  CB  . ASP A 1 408 ? 7.387   -35.564 -40.115 1.00 38.68  ? 671  ASP A CB  1 
ATOM   2878 C  CG  . ASP A 1 408 ? 7.414   -34.065 -40.045 1.00 37.12  ? 671  ASP A CG  1 
ATOM   2879 O  OD1 . ASP A 1 408 ? 7.738   -33.563 -38.929 1.00 40.26  ? 671  ASP A OD1 1 
ATOM   2880 O  OD2 . ASP A 1 408 ? 7.037   -33.406 -41.061 1.00 40.02  ? 671  ASP A OD2 1 
ATOM   2881 N  N   . ASP A 1 409 ? 7.936   -36.378 -37.249 1.00 42.95  ? 672  ASP A N   1 
ATOM   2882 C  CA  . ASP A 1 409 ? 8.261   -36.410 -35.797 1.00 38.08  ? 672  ASP A CA  1 
ATOM   2883 C  C   . ASP A 1 409 ? 8.893   -35.109 -35.299 1.00 35.67  ? 672  ASP A C   1 
ATOM   2884 O  O   . ASP A 1 409 ? 9.160   -35.059 -34.098 1.00 36.10  ? 672  ASP A O   1 
ATOM   2885 C  CB  . ASP A 1 409 ? 8.988   -37.701 -35.459 1.00 39.83  ? 672  ASP A CB  1 
ATOM   2886 C  CG  . ASP A 1 409 ? 8.073   -38.895 -35.682 1.00 41.73  ? 672  ASP A CG  1 
ATOM   2887 O  OD1 . ASP A 1 409 ? 6.954   -38.868 -35.118 1.00 36.00  ? 672  ASP A OD1 1 
ATOM   2888 O  OD2 . ASP A 1 409 ? 8.467   -39.815 -36.460 1.00 44.41  ? 672  ASP A OD2 1 
ATOM   2889 N  N   . ARG A 1 410 ? 8.932   -34.021 -36.078 1.00 33.72  ? 673  ARG A N   1 
ATOM   2890 C  CA  . ARG A 1 410 ? 9.398   -32.709 -35.532 1.00 35.14  ? 673  ARG A CA  1 
ATOM   2891 C  C   . ARG A 1 410 ? 8.451   -32.262 -34.426 1.00 36.11  ? 673  ARG A C   1 
ATOM   2892 O  O   . ARG A 1 410 ? 8.867   -31.509 -33.529 1.00 40.01  ? 673  ARG A O   1 
ATOM   2893 C  CB  . ARG A 1 410 ? 9.424   -31.593 -36.590 1.00 43.92  ? 673  ARG A CB  1 
ATOM   2894 C  CG  . ARG A 1 410 ? 10.430  -31.789 -37.714 1.00 46.61  ? 673  ARG A CG  1 
ATOM   2895 C  CD  . ARG A 1 410 ? 10.211  -30.796 -38.833 1.00 48.34  ? 673  ARG A CD  1 
ATOM   2896 N  NE  . ARG A 1 410 ? 9.069   -31.158 -39.654 1.00 52.26  ? 673  ARG A NE  1 
ATOM   2897 C  CZ  . ARG A 1 410 ? 8.593   -30.439 -40.672 1.00 56.76  ? 673  ARG A CZ  1 
ATOM   2898 N  NH1 . ARG A 1 410 ? 9.155   -29.282 -40.984 1.00 50.60  ? 673  ARG A NH1 1 
ATOM   2899 N  NH2 . ARG A 1 410 ? 7.544   -30.872 -41.361 1.00 54.38  ? 673  ARG A NH2 1 
ATOM   2900 N  N   . PHE A 1 411 ? 7.167   -32.641 -34.535 1.00 40.42  ? 674  PHE A N   1 
ATOM   2901 C  CA  . PHE A 1 411 ? 6.126   -32.336 -33.526 1.00 31.97  ? 674  PHE A CA  1 
ATOM   2902 C  C   . PHE A 1 411 ? 6.647   -32.658 -32.116 1.00 30.48  ? 674  PHE A C   1 
ATOM   2903 O  O   . PHE A 1 411 ? 6.339   -31.899 -31.158 1.00 32.31  ? 674  PHE A O   1 
ATOM   2904 C  CB  . PHE A 1 411 ? 4.878   -33.158 -33.867 1.00 42.86  ? 674  PHE A CB  1 
ATOM   2905 C  CG  . PHE A 1 411 ? 3.699   -32.989 -32.951 1.00 34.60  ? 674  PHE A CG  1 
ATOM   2906 C  CD1 . PHE A 1 411 ? 3.561   -33.791 -31.815 1.00 38.04  ? 674  PHE A CD1 1 
ATOM   2907 C  CD2 . PHE A 1 411 ? 2.682   -32.100 -33.277 1.00 38.45  ? 674  PHE A CD2 1 
ATOM   2908 C  CE1 . PHE A 1 411 ? 2.420   -33.685 -31.018 1.00 39.01  ? 674  PHE A CE1 1 
ATOM   2909 C  CE2 . PHE A 1 411 ? 1.570   -31.951 -32.451 1.00 33.11  ? 674  PHE A CE2 1 
ATOM   2910 C  CZ  . PHE A 1 411 ? 1.439   -32.747 -31.320 1.00 35.50  ? 674  PHE A CZ  1 
ATOM   2911 N  N   . ALA A 1 412 ? 7.390   -33.763 -31.966 1.00 32.89  ? 675  ALA A N   1 
ATOM   2912 C  CA  . ALA A 1 412 ? 7.863   -34.304 -30.664 1.00 34.23  ? 675  ALA A CA  1 
ATOM   2913 C  C   . ALA A 1 412 ? 8.674   -33.274 -29.874 1.00 35.56  ? 675  ALA A C   1 
ATOM   2914 O  O   . ALA A 1 412 ? 8.554   -33.249 -28.638 1.00 36.26  ? 675  ALA A O   1 
ATOM   2915 C  CB  . ALA A 1 412 ? 8.634   -35.593 -30.875 1.00 32.28  ? 675  ALA A CB  1 
ATOM   2916 N  N   . SER A 1 413 ? 9.443   -32.417 -30.541 1.00 35.94  ? 676  SER A N   1 
ATOM   2917 C  CA  . SER A 1 413 ? 10.285  -31.408 -29.842 1.00 40.69  ? 676  SER A CA  1 
ATOM   2918 C  C   . SER A 1 413 ? 9.758   -29.991 -30.061 1.00 41.58  ? 676  SER A C   1 
ATOM   2919 O  O   . SER A 1 413 ? 10.421  -29.072 -29.587 1.00 44.68  ? 676  SER A O   1 
ATOM   2920 C  CB  . SER A 1 413 ? 11.761  -31.533 -30.205 1.00 40.50  ? 676  SER A CB  1 
ATOM   2921 O  OG  . SER A 1 413 ? 11.926  -31.991 -31.538 1.00 43.30  ? 676  SER A OG  1 
ATOM   2922 N  N   . ALA A 1 414 ? 8.587   -29.817 -30.678 1.00 45.01  ? 677  ALA A N   1 
ATOM   2923 C  CA  . ALA A 1 414 ? 7.937   -28.489 -30.877 1.00 44.69  ? 677  ALA A CA  1 
ATOM   2924 C  C   . ALA A 1 414 ? 7.209   -28.096 -29.594 1.00 47.73  ? 677  ALA A C   1 
ATOM   2925 O  O   . ALA A 1 414 ? 5.982   -28.350 -29.493 1.00 53.91  ? 677  ALA A O   1 
ATOM   2926 C  CB  . ALA A 1 414 ? 6.980   -28.543 -32.054 1.00 49.14  ? 677  ALA A CB  1 
ATOM   2927 N  N   . LEU A 1 415 ? 7.907   -27.525 -28.626 1.00 39.44  ? 678  LEU A N   1 
ATOM   2928 C  CA  . LEU A 1 415 ? 7.387   -27.410 -27.245 1.00 39.88  ? 678  LEU A CA  1 
ATOM   2929 C  C   . LEU A 1 415 ? 7.221   -25.956 -26.805 1.00 40.10  ? 678  LEU A C   1 
ATOM   2930 O  O   . LEU A 1 415 ? 6.699   -25.768 -25.702 1.00 44.02  ? 678  LEU A O   1 
ATOM   2931 C  CB  . LEU A 1 415 ? 8.305   -28.178 -26.295 1.00 42.56  ? 678  LEU A CB  1 
ATOM   2932 C  CG  . LEU A 1 415 ? 8.413   -29.695 -26.515 1.00 46.75  ? 678  LEU A CG  1 
ATOM   2933 C  CD1 . LEU A 1 415 ? 9.488   -30.324 -25.603 1.00 41.10  ? 678  LEU A CD1 1 
ATOM   2934 C  CD2 . LEU A 1 415 ? 7.078   -30.382 -26.287 1.00 49.36  ? 678  LEU A CD2 1 
ATOM   2935 N  N   . THR A 1 416 ? 7.596   -24.951 -27.601 1.00 43.37  ? 679  THR A N   1 
ATOM   2936 C  CA  . THR A 1 416 ? 7.669   -23.557 -27.066 1.00 47.68  ? 679  THR A CA  1 
ATOM   2937 C  C   . THR A 1 416 ? 6.247   -23.022 -26.896 1.00 45.68  ? 679  THR A C   1 
ATOM   2938 O  O   . THR A 1 416 ? 5.926   -22.540 -25.788 1.00 46.65  ? 679  THR A O   1 
ATOM   2939 C  CB  . THR A 1 416 ? 8.548   -22.608 -27.897 1.00 50.71  ? 679  THR A CB  1 
ATOM   2940 O  OG1 . THR A 1 416 ? 8.061   -22.402 -29.230 1.00 47.49  ? 679  THR A OG1 1 
ATOM   2941 C  CG2 . THR A 1 416 ? 9.968   -23.121 -27.977 1.00 56.88  ? 679  THR A CG2 1 
ATOM   2942 N  N   . ALA A 1 417 ? 5.434   -23.092 -27.955 1.00 44.72  ? 680  ALA A N   1 
ATOM   2943 C  CA  . ALA A 1 417 ? 4.025   -22.622 -27.938 1.00 42.79  ? 680  ALA A CA  1 
ATOM   2944 C  C   . ALA A 1 417 ? 3.236   -23.382 -26.863 1.00 41.38  ? 680  ALA A C   1 
ATOM   2945 O  O   . ALA A 1 417 ? 2.518   -22.738 -26.039 1.00 44.69  ? 680  ALA A O   1 
ATOM   2946 C  CB  . ALA A 1 417 ? 3.420   -22.762 -29.310 1.00 45.71  ? 680  ALA A CB  1 
ATOM   2947 N  N   . LEU A 1 418 ? 3.367   -24.710 -26.827 1.00 42.42  ? 681  LEU A N   1 
ATOM   2948 C  CA  . LEU A 1 418 ? 2.576   -25.550 -25.885 1.00 38.81  ? 681  LEU A CA  1 
ATOM   2949 C  C   . LEU A 1 418 ? 2.882   -25.166 -24.430 1.00 42.45  ? 681  LEU A C   1 
ATOM   2950 O  O   . LEU A 1 418 ? 1.945   -25.040 -23.644 1.00 42.10  ? 681  LEU A O   1 
ATOM   2951 C  CB  . LEU A 1 418 ? 2.945   -27.000 -26.159 1.00 41.53  ? 681  LEU A CB  1 
ATOM   2952 C  CG  . LEU A 1 418 ? 2.171   -28.008 -25.319 1.00 45.20  ? 681  LEU A CG  1 
ATOM   2953 C  CD1 . LEU A 1 418 ? 0.716   -28.087 -25.794 1.00 41.14  ? 681  LEU A CD1 1 
ATOM   2954 C  CD2 . LEU A 1 418 ? 2.860   -29.377 -25.381 1.00 39.97  ? 681  LEU A CD2 1 
ATOM   2955 N  N   . ASN A 1 419 ? 4.170   -24.999 -24.087 1.00 44.23  ? 682  ASN A N   1 
ATOM   2956 C  CA  . ASN A 1 419 ? 4.630   -24.609 -22.732 1.00 42.52  ? 682  ASN A CA  1 
ATOM   2957 C  C   . ASN A 1 419 ? 4.215   -23.158 -22.422 1.00 44.31  ? 682  ASN A C   1 
ATOM   2958 O  O   . ASN A 1 419 ? 3.722   -22.914 -21.302 1.00 44.96  ? 682  ASN A O   1 
ATOM   2959 C  CB  . ASN A 1 419 ? 6.139   -24.810 -22.620 1.00 46.14  ? 682  ASN A CB  1 
ATOM   2960 C  CG  . ASN A 1 419 ? 6.543   -26.252 -22.378 1.00 46.44  ? 682  ASN A CG  1 
ATOM   2961 O  OD1 . ASN A 1 419 ? 5.863   -26.990 -21.658 1.00 47.56  ? 682  ASN A OD1 1 
ATOM   2962 N  ND2 . ASN A 1 419 ? 7.646   -26.668 -22.973 1.00 44.74  ? 682  ASN A ND2 1 
ATOM   2963 N  N   . ASP A 1 420 ? 4.385   -22.224 -23.363 1.00 41.66  ? 683  ASP A N   1 
ATOM   2964 C  CA  . ASP A 1 420 ? 3.994   -20.796 -23.171 1.00 46.77  ? 683  ASP A CA  1 
ATOM   2965 C  C   . ASP A 1 420 ? 2.455   -20.610 -23.089 1.00 46.07  ? 683  ASP A C   1 
ATOM   2966 O  O   . ASP A 1 420 ? 2.004   -19.742 -22.293 1.00 46.70  ? 683  ASP A O   1 
ATOM   2967 C  CB  . ASP A 1 420 ? 4.588   -19.898 -24.262 1.00 48.26  ? 683  ASP A CB  1 
ATOM   2968 C  CG  . ASP A 1 420 ? 4.428   -18.429 -23.918 1.00 50.94  ? 683  ASP A CG  1 
ATOM   2969 O  OD1 . ASP A 1 420 ? 4.704   -18.079 -22.755 1.00 49.66  ? 683  ASP A OD1 1 
ATOM   2970 O  OD2 . ASP A 1 420 ? 3.956   -17.657 -24.790 1.00 51.71  ? 683  ASP A OD2 1 
ATOM   2971 N  N   . MET A 1 421 ? 1.640   -21.413 -23.787 1.00 44.12  ? 684  MET A N   1 
ATOM   2972 C  CA  . MET A 1 421 ? 0.149   -21.403 -23.583 1.00 41.06  ? 684  MET A CA  1 
ATOM   2973 C  C   . MET A 1 421 ? -0.217  -21.954 -22.194 1.00 43.29  ? 684  MET A C   1 
ATOM   2974 O  O   . MET A 1 421 ? -1.409  -21.909 -21.848 1.00 50.76  ? 684  MET A O   1 
ATOM   2975 C  CB  . MET A 1 421 ? -0.568  -22.233 -24.648 1.00 43.43  ? 684  MET A CB  1 
ATOM   2976 C  CG  . MET A 1 421 ? -0.437  -21.656 -26.044 1.00 43.84  ? 684  MET A CG  1 
ATOM   2977 S  SD  . MET A 1 421 ? -1.385  -22.574 -27.272 1.00 50.31  ? 684  MET A SD  1 
ATOM   2978 C  CE  . MET A 1 421 ? -0.408  -24.053 -27.526 1.00 56.88  ? 684  MET A CE  1 
ATOM   2979 N  N   . GLY A 1 422 ? 0.737   -22.525 -21.449 1.00 43.00  ? 685  GLY A N   1 
ATOM   2980 C  CA  . GLY A 1 422 ? 0.522   -23.102 -20.099 1.00 39.28  ? 685  GLY A CA  1 
ATOM   2981 C  C   . GLY A 1 422 ? 0.087   -24.556 -20.088 1.00 38.37  ? 685  GLY A C   1 
ATOM   2982 O  O   . GLY A 1 422 ? -0.140  -25.060 -18.987 1.00 37.71  ? 685  GLY A O   1 
ATOM   2983 N  N   . LYS A 1 423 ? 0.027   -25.230 -21.243 1.00 38.68  ? 686  LYS A N   1 
ATOM   2984 C  CA  . LYS A 1 423 ? -0.418  -26.653 -21.356 1.00 42.26  ? 686  LYS A CA  1 
ATOM   2985 C  C   . LYS A 1 423 ? 0.793   -27.583 -21.195 1.00 46.32  ? 686  LYS A C   1 
ATOM   2986 O  O   . LYS A 1 423 ? 1.135   -28.365 -22.109 1.00 42.74  ? 686  LYS A O   1 
ATOM   2987 C  CB  . LYS A 1 423 ? -1.202  -26.825 -22.658 1.00 43.00  ? 686  LYS A CB  1 
ATOM   2988 C  CG  . LYS A 1 423 ? -2.336  -25.810 -22.804 1.00 43.32  ? 686  LYS A CG  1 
ATOM   2989 C  CD  . LYS A 1 423 ? -3.251  -25.759 -21.558 1.00 47.19  ? 686  LYS A CD  1 
ATOM   2990 C  CE  . LYS A 1 423 ? -4.360  -24.732 -21.633 1.00 49.04  ? 686  LYS A CE  1 
ATOM   2991 N  NZ  . LYS A 1 423 ? -3.867  -23.406 -22.075 1.00 53.74  ? 686  LYS A NZ  1 
ATOM   2992 N  N   . VAL A 1 424 ? 1.372   -27.517 -20.006 1.00 49.44  ? 687  VAL A N   1 
ATOM   2993 C  CA  . VAL A 1 424 ? 2.600   -28.247 -19.592 1.00 49.39  ? 687  VAL A CA  1 
ATOM   2994 C  C   . VAL A 1 424 ? 2.279   -29.744 -19.548 1.00 40.30  ? 687  VAL A C   1 
ATOM   2995 O  O   . VAL A 1 424 ? 1.251   -30.104 -18.945 1.00 43.30  ? 687  VAL A O   1 
ATOM   2996 C  CB  . VAL A 1 424 ? 3.059   -27.677 -18.229 1.00 56.10  ? 687  VAL A CB  1 
ATOM   2997 C  CG1 . VAL A 1 424 ? 3.873   -28.661 -17.403 1.00 61.33  ? 687  VAL A CG1 1 
ATOM   2998 C  CG2 . VAL A 1 424 ? 3.806   -26.366 -18.430 1.00 50.46  ? 687  VAL A CG2 1 
ATOM   2999 N  N   . ARG A 1 425 ? 3.102   -30.580 -20.181 1.00 35.15  ? 688  ARG A N   1 
ATOM   3000 C  CA  . ARG A 1 425 ? 2.823   -32.034 -20.281 1.00 38.89  ? 688  ARG A CA  1 
ATOM   3001 C  C   . ARG A 1 425 ? 3.012   -32.665 -18.893 1.00 44.50  ? 688  ARG A C   1 
ATOM   3002 O  O   . ARG A 1 425 ? 3.835   -32.129 -18.114 1.00 46.45  ? 688  ARG A O   1 
ATOM   3003 C  CB  . ARG A 1 425 ? 3.689   -32.680 -21.357 1.00 39.07  ? 688  ARG A CB  1 
ATOM   3004 C  CG  . ARG A 1 425 ? 3.435   -32.127 -22.748 1.00 41.40  ? 688  ARG A CG  1 
ATOM   3005 C  CD  . ARG A 1 425 ? 4.574   -32.426 -23.688 1.00 44.05  ? 688  ARG A CD  1 
ATOM   3006 N  NE  . ARG A 1 425 ? 5.850   -31.885 -23.215 1.00 44.07  ? 688  ARG A NE  1 
ATOM   3007 C  CZ  . ARG A 1 425 ? 7.062   -32.384 -23.502 1.00 42.52  ? 688  ARG A CZ  1 
ATOM   3008 N  NH1 . ARG A 1 425 ? 7.215   -33.434 -24.305 1.00 37.87  ? 688  ARG A NH1 1 
ATOM   3009 N  NH2 . ARG A 1 425 ? 8.130   -31.805 -22.973 1.00 49.07  ? 688  ARG A NH2 1 
ATOM   3010 N  N   . LYS A 1 426 ? 2.245   -33.722 -18.582 1.00 46.49  ? 689  LYS A N   1 
ATOM   3011 C  CA  . LYS A 1 426 ? 2.359   -34.517 -17.321 1.00 53.17  ? 689  LYS A CA  1 
ATOM   3012 C  C   . LYS A 1 426 ? 3.568   -35.484 -17.390 1.00 56.98  ? 689  LYS A C   1 
ATOM   3013 O  O   . LYS A 1 426 ? 3.828   -36.048 -18.481 1.00 54.28  ? 689  LYS A O   1 
ATOM   3014 C  CB  . LYS A 1 426 ? 1.062   -35.291 -17.087 1.00 56.58  ? 689  LYS A CB  1 
ATOM   3015 C  CG  . LYS A 1 426 ? 0.843   -35.793 -15.663 1.00 66.22  ? 689  LYS A CG  1 
ATOM   3016 C  CD  . LYS A 1 426 ? -0.509  -36.444 -15.423 1.00 67.21  ? 689  LYS A CD  1 
ATOM   3017 C  CE  . LYS A 1 426 ? -0.920  -37.346 -16.564 1.00 79.37  ? 689  LYS A CE  1 
ATOM   3018 N  NZ  . LYS A 1 426 ? -1.955  -38.325 -16.160 1.00 91.74  ? 689  LYS A NZ  1 
ATOM   3019 N  N   . ASP A 1 427 ? 4.301   -35.646 -16.277 1.00 55.41  ? 690  ASP A N   1 
ATOM   3020 C  CA  . ASP A 1 427 ? 5.342   -36.697 -16.063 1.00 58.21  ? 690  ASP A CA  1 
ATOM   3021 C  C   . ASP A 1 427 ? 6.428   -36.720 -17.158 1.00 55.72  ? 690  ASP A C   1 
ATOM   3022 O  O   . ASP A 1 427 ? 6.739   -37.820 -17.672 1.00 58.97  ? 690  ASP A O   1 
ATOM   3023 C  CB  . ASP A 1 427 ? 4.682   -38.069 -15.997 1.00 63.13  ? 690  ASP A CB  1 
ATOM   3024 C  CG  . ASP A 1 427 ? 3.794   -38.232 -14.786 1.00 68.30  ? 690  ASP A CG  1 
ATOM   3025 O  OD1 . ASP A 1 427 ? 4.028   -37.496 -13.776 1.00 65.66  ? 690  ASP A OD1 1 
ATOM   3026 O  OD2 . ASP A 1 427 ? 2.885   -39.089 -14.869 1.00 73.34  ? 690  ASP A OD2 1 
ATOM   3027 N  N   . ILE A 1 428 ? 7.001   -35.569 -17.502 1.00 47.49  ? 691  ILE A N   1 
ATOM   3028 C  CA  . ILE A 1 428 ? 8.148   -35.467 -18.449 1.00 46.92  ? 691  ILE A CA  1 
ATOM   3029 C  C   . ILE A 1 428 ? 8.745   -34.076 -18.283 1.00 48.96  ? 691  ILE A C   1 
ATOM   3030 O  O   . ILE A 1 428 ? 7.968   -33.139 -18.057 1.00 56.58  ? 691  ILE A O   1 
ATOM   3031 C  CB  . ILE A 1 428 ? 7.712   -35.761 -19.902 1.00 54.04  ? 691  ILE A CB  1 
ATOM   3032 C  CG1 . ILE A 1 428 ? 8.918   -35.853 -20.841 1.00 55.37  ? 691  ILE A CG1 1 
ATOM   3033 C  CG2 . ILE A 1 428 ? 6.683   -34.750 -20.403 1.00 53.13  ? 691  ILE A CG2 1 
ATOM   3034 C  CD1 . ILE A 1 428 ? 8.643   -36.562 -22.150 1.00 57.69  ? 691  ILE A CD1 1 
ATOM   3035 N  N   . GLN A 1 429 ? 10.067  -33.948 -18.335 1.00 51.57  ? 692  GLN A N   1 
ATOM   3036 C  CA  . GLN A 1 429 ? 10.754  -32.642 -18.166 1.00 55.08  ? 692  GLN A CA  1 
ATOM   3037 C  C   . GLN A 1 429 ? 10.229  -31.684 -19.237 1.00 48.94  ? 692  GLN A C   1 
ATOM   3038 O  O   . GLN A 1 429 ? 10.047  -32.097 -20.417 1.00 44.24  ? 692  GLN A O   1 
ATOM   3039 C  CB  . GLN A 1 429 ? 12.285  -32.785 -18.218 1.00 67.67  ? 692  GLN A CB  1 
ATOM   3040 C  CG  . GLN A 1 429 ? 12.931  -33.107 -16.864 1.00 81.10  ? 692  GLN A CG  1 
ATOM   3041 C  CD  . GLN A 1 429 ? 14.266  -33.827 -16.940 1.00 93.38  ? 692  GLN A CD  1 
ATOM   3042 O  OE1 . GLN A 1 429 ? 14.685  -34.318 -17.993 1.00 99.96  ? 692  GLN A OE1 1 
ATOM   3043 N  NE2 . GLN A 1 429 ? 14.956  -33.912 -15.808 1.00 92.44  ? 692  GLN A NE2 1 
ATOM   3044 N  N   . GLN A 1 430 ? 10.091  -30.429 -18.845 1.00 51.54  ? 693  GLN A N   1 
ATOM   3045 C  CA  . GLN A 1 430 ? 9.444   -29.370 -19.644 1.00 58.82  ? 693  GLN A CA  1 
ATOM   3046 C  C   . GLN A 1 430 ? 9.976   -29.371 -21.076 1.00 53.53  ? 693  GLN A C   1 
ATOM   3047 O  O   . GLN A 1 430 ? 9.148   -29.136 -21.976 1.00 54.36  ? 693  GLN A O   1 
ATOM   3048 C  CB  . GLN A 1 430 ? 9.596   -27.997 -18.985 1.00 68.31  ? 693  GLN A CB  1 
ATOM   3049 C  CG  . GLN A 1 430 ? 8.279   -27.220 -19.003 1.00 78.41  ? 693  GLN A CG  1 
ATOM   3050 C  CD  . GLN A 1 430 ? 8.390   -25.711 -18.993 1.00 85.69  ? 693  GLN A CD  1 
ATOM   3051 O  OE1 . GLN A 1 430 ? 9.442   -25.143 -19.304 1.00 75.09  ? 693  GLN A OE1 1 
ATOM   3052 N  NE2 . GLN A 1 430 ? 7.325   -25.042 -18.582 1.00 84.38  ? 693  GLN A NE2 1 
ATOM   3053 N  N   . TRP A 1 431 ? 11.277  -29.602 -21.295 1.00 51.02  ? 694  TRP A N   1 
ATOM   3054 C  CA  . TRP A 1 431 ? 11.920  -29.416 -22.628 1.00 48.19  ? 694  TRP A CA  1 
ATOM   3055 C  C   . TRP A 1 431 ? 12.406  -30.743 -23.204 1.00 46.09  ? 694  TRP A C   1 
ATOM   3056 O  O   . TRP A 1 431 ? 12.984  -30.715 -24.287 1.00 47.06  ? 694  TRP A O   1 
ATOM   3057 C  CB  . TRP A 1 431 ? 13.016  -28.342 -22.583 1.00 55.53  ? 694  TRP A CB  1 
ATOM   3058 C  CG  . TRP A 1 431 ? 12.480  -26.995 -22.187 1.00 56.12  ? 694  TRP A CG  1 
ATOM   3059 C  CD1 . TRP A 1 431 ? 12.622  -26.375 -20.979 1.00 54.18  ? 694  TRP A CD1 1 
ATOM   3060 C  CD2 . TRP A 1 431 ? 11.618  -26.141 -22.972 1.00 59.99  ? 694  TRP A CD2 1 
ATOM   3061 N  NE1 . TRP A 1 431 ? 11.951  -25.177 -20.977 1.00 58.74  ? 694  TRP A NE1 1 
ATOM   3062 C  CE2 . TRP A 1 431 ? 11.315  -25.011 -22.177 1.00 57.08  ? 694  TRP A CE2 1 
ATOM   3063 C  CE3 . TRP A 1 431 ? 11.070  -26.221 -24.261 1.00 53.06  ? 694  TRP A CE3 1 
ATOM   3064 C  CZ2 . TRP A 1 431 ? 10.480  -23.993 -22.625 1.00 56.62  ? 694  TRP A CZ2 1 
ATOM   3065 C  CZ3 . TRP A 1 431 ? 10.290  -25.185 -24.725 1.00 53.40  ? 694  TRP A CZ3 1 
ATOM   3066 C  CH2 . TRP A 1 431 ? 9.984   -24.098 -23.909 1.00 56.03  ? 694  TRP A CH2 1 
ATOM   3067 N  N   . GLU A 1 432 ? 12.033  -31.858 -22.578 1.00 45.41  ? 695  GLU A N   1 
ATOM   3068 C  CA  . GLU A 1 432 ? 12.277  -33.230 -23.088 1.00 50.84  ? 695  GLU A CA  1 
ATOM   3069 C  C   . GLU A 1 432 ? 11.293  -33.533 -24.228 1.00 50.82  ? 695  GLU A C   1 
ATOM   3070 O  O   . GLU A 1 432 ? 10.101  -33.307 -24.085 1.00 45.09  ? 695  GLU A O   1 
ATOM   3071 C  CB  . GLU A 1 432 ? 12.132  -34.205 -21.912 1.00 54.85  ? 695  GLU A CB  1 
ATOM   3072 C  CG  . GLU A 1 432 ? 12.729  -35.575 -22.162 1.00 64.73  ? 695  GLU A CG  1 
ATOM   3073 C  CD  . GLU A 1 432 ? 14.226  -35.561 -22.475 1.00 74.48  ? 695  GLU A CD  1 
ATOM   3074 O  OE1 . GLU A 1 432 ? 14.644  -36.441 -23.276 1.00 70.13  ? 695  GLU A OE1 1 
ATOM   3075 O  OE2 . GLU A 1 432 ? 14.980  -34.670 -21.923 1.00 66.49  ? 695  GLU A OE2 1 
ATOM   3076 N  N   . PRO A 1 433 ? 11.732  -34.054 -25.396 1.00 47.25  ? 696  PRO A N   1 
ATOM   3077 C  CA  . PRO A 1 433 ? 10.810  -34.389 -26.481 1.00 40.01  ? 696  PRO A CA  1 
ATOM   3078 C  C   . PRO A 1 433 ? 9.808   -35.492 -26.145 1.00 40.87  ? 696  PRO A C   1 
ATOM   3079 O  O   . PRO A 1 433 ? 10.120  -36.387 -25.414 1.00 38.86  ? 696  PRO A O   1 
ATOM   3080 C  CB  . PRO A 1 433 ? 11.709  -34.882 -27.617 1.00 46.10  ? 696  PRO A CB  1 
ATOM   3081 C  CG  . PRO A 1 433 ? 13.088  -34.286 -27.271 1.00 48.55  ? 696  PRO A CG  1 
ATOM   3082 C  CD  . PRO A 1 433 ? 13.135  -34.321 -25.763 1.00 48.09  ? 696  PRO A CD  1 
ATOM   3083 N  N   . SER A 1 434 ? 8.597   -35.376 -26.691 1.00 42.91  ? 697  SER A N   1 
ATOM   3084 C  CA  . SER A 1 434 ? 7.500   -36.323 -26.431 1.00 39.14  ? 697  SER A CA  1 
ATOM   3085 C  C   . SER A 1 434 ? 7.931   -37.669 -26.998 1.00 40.35  ? 697  SER A C   1 
ATOM   3086 O  O   . SER A 1 434 ? 8.532   -37.690 -28.034 1.00 43.89  ? 697  SER A O   1 
ATOM   3087 C  CB  . SER A 1 434 ? 6.211   -35.864 -27.090 1.00 35.02  ? 697  SER A CB  1 
ATOM   3088 O  OG  . SER A 1 434 ? 5.769   -34.646 -26.539 1.00 35.33  ? 697  SER A OG  1 
ATOM   3089 N  N   . ARG A 1 435 ? 7.610   -38.754 -26.295 0.50 43.61  ? 698  ARG A N   1 
ATOM   3090 C  CA  . ARG A 1 435 ? 7.760   -40.151 -26.780 0.50 49.67  ? 698  ARG A CA  1 
ATOM   3091 C  C   . ARG A 1 435 ? 6.421   -40.577 -27.394 0.50 49.01  ? 698  ARG A C   1 
ATOM   3092 O  O   . ARG A 1 435 ? 5.414   -40.589 -26.658 0.50 49.97  ? 698  ARG A O   1 
ATOM   3093 C  CB  . ARG A 1 435 ? 8.218   -41.054 -25.628 0.50 56.14  ? 698  ARG A CB  1 
ATOM   3094 C  CG  . ARG A 1 435 ? 9.640   -40.762 -25.162 0.50 62.21  ? 698  ARG A CG  1 
ATOM   3095 C  CD  . ARG A 1 435 ? 10.082  -41.577 -23.960 0.50 70.62  ? 698  ARG A CD  1 
ATOM   3096 N  NE  . ARG A 1 435 ? 9.554   -41.063 -22.701 0.50 78.65  ? 698  ARG A NE  1 
ATOM   3097 C  CZ  . ARG A 1 435 ? 10.087  -40.060 -22.004 0.50 82.61  ? 698  ARG A CZ  1 
ATOM   3098 N  NH1 . ARG A 1 435 ? 11.172  -39.447 -22.448 0.50 83.26  ? 698  ARG A NH1 1 
ATOM   3099 N  NH2 . ARG A 1 435 ? 9.529   -39.669 -20.871 0.50 81.96  ? 698  ARG A NH2 1 
ATOM   3100 N  N   . GLY A 1 436 ? 6.414   -40.862 -28.699 1.00 46.05  ? 699  GLY A N   1 
ATOM   3101 C  CA  . GLY A 1 436 ? 5.201   -41.234 -29.450 1.00 48.38  ? 699  GLY A CA  1 
ATOM   3102 C  C   . GLY A 1 436 ? 5.032   -42.741 -29.559 1.00 45.91  ? 699  GLY A C   1 
ATOM   3103 O  O   . GLY A 1 436 ? 5.928   -43.459 -29.171 1.00 44.42  ? 699  GLY A O   1 
ATOM   3104 N  N   . TRP A 1 437 ? 3.908   -43.194 -30.099 1.00 41.70  ? 700  TRP A N   1 
ATOM   3105 C  CA  . TRP A 1 437 ? 3.552   -44.624 -30.187 1.00 38.63  ? 700  TRP A CA  1 
ATOM   3106 C  C   . TRP A 1 437 ? 3.621   -45.001 -31.647 1.00 37.43  ? 700  TRP A C   1 
ATOM   3107 O  O   . TRP A 1 437 ? 3.192   -44.167 -32.450 1.00 36.57  ? 700  TRP A O   1 
ATOM   3108 C  CB  . TRP A 1 437 ? 2.153   -44.871 -29.621 1.00 36.36  ? 700  TRP A CB  1 
ATOM   3109 C  CG  . TRP A 1 437 ? 1.967   -44.372 -28.230 1.00 31.21  ? 700  TRP A CG  1 
ATOM   3110 C  CD1 . TRP A 1 437 ? 1.677   -43.109 -27.811 1.00 31.92  ? 700  TRP A CD1 1 
ATOM   3111 C  CD2 . TRP A 1 437 ? 2.058   -45.175 -27.059 1.00 29.98  ? 700  TRP A CD2 1 
ATOM   3112 N  NE1 . TRP A 1 437 ? 1.594   -43.073 -26.450 1.00 30.89  ? 700  TRP A NE1 1 
ATOM   3113 C  CE2 . TRP A 1 437 ? 1.799   -44.332 -25.965 1.00 29.28  ? 700  TRP A CE2 1 
ATOM   3114 C  CE3 . TRP A 1 437 ? 2.309   -46.524 -26.862 1.00 33.19  ? 700  TRP A CE3 1 
ATOM   3115 C  CZ2 . TRP A 1 437 ? 1.841   -44.789 -24.663 1.00 28.74  ? 700  TRP A CZ2 1 
ATOM   3116 C  CZ3 . TRP A 1 437 ? 2.329   -46.976 -25.578 1.00 34.38  ? 700  TRP A CZ3 1 
ATOM   3117 C  CH2 . TRP A 1 437 ? 2.125   -46.115 -24.506 1.00 32.70  ? 700  TRP A CH2 1 
ATOM   3118 N  N   . ASN A 1 438 ? 4.135   -46.184 -31.965 1.00 37.19  ? 701  ASN A N   1 
ATOM   3119 C  CA  . ASN A 1 438 ? 4.300   -46.634 -33.373 1.00 45.00  ? 701  ASN A CA  1 
ATOM   3120 C  C   . ASN A 1 438 ? 3.119   -47.481 -33.818 1.00 43.08  ? 701  ASN A C   1 
ATOM   3121 O  O   . ASN A 1 438 ? 3.087   -47.817 -35.013 1.00 43.77  ? 701  ASN A O   1 
ATOM   3122 C  CB  . ASN A 1 438 ? 5.574   -47.477 -33.553 1.00 52.55  ? 701  ASN A CB  1 
ATOM   3123 C  CG  . ASN A 1 438 ? 6.824   -46.645 -33.357 1.00 55.34  ? 701  ASN A CG  1 
ATOM   3124 O  OD1 . ASN A 1 438 ? 7.665   -46.944 -32.493 1.00 69.52  ? 701  ASN A OD1 1 
ATOM   3125 N  ND2 . ASN A 1 438 ? 6.885   -45.551 -34.100 1.00 47.76  ? 701  ASN A ND2 1 
ATOM   3126 N  N   . ASP A 1 439 ? 2.262   -47.879 -32.875 1.00 45.66  ? 702  ASP A N   1 
ATOM   3127 C  CA  . ASP A 1 439 ? 1.152   -48.849 -33.110 1.00 52.41  ? 702  ASP A CA  1 
ATOM   3128 C  C   . ASP A 1 439 ? -0.132  -48.252 -32.510 1.00 43.86  ? 702  ASP A C   1 
ATOM   3129 O  O   . ASP A 1 439 ? -0.161  -47.970 -31.289 1.00 42.59  ? 702  ASP A O   1 
ATOM   3130 C  CB  . ASP A 1 439 ? 1.612   -50.192 -32.531 1.00 54.05  ? 702  ASP A CB  1 
ATOM   3131 C  CG  . ASP A 1 439 ? 0.651   -51.370 -32.585 1.00 63.27  ? 702  ASP A CG  1 
ATOM   3132 O  OD1 . ASP A 1 439 ? -0.462  -51.215 -33.187 1.00 56.33  ? 702  ASP A OD1 1 
ATOM   3133 O  OD2 . ASP A 1 439 ? 1.054   -52.461 -32.025 1.00 59.69  ? 702  ASP A OD2 1 
ATOM   3134 N  N   . TRP A 1 440 ? -1.167  -48.038 -33.312 1.00 42.57  ? 703  TRP A N   1 
ATOM   3135 C  CA  . TRP A 1 440 ? -2.445  -47.444 -32.824 1.00 38.82  ? 703  TRP A CA  1 
ATOM   3136 C  C   . TRP A 1 440 ? -3.080  -48.299 -31.706 1.00 36.46  ? 703  TRP A C   1 
ATOM   3137 O  O   . TRP A 1 440 ? -3.792  -47.739 -30.865 1.00 38.29  ? 703  TRP A O   1 
ATOM   3138 C  CB  . TRP A 1 440 ? -3.372  -47.165 -33.997 1.00 36.65  ? 703  TRP A CB  1 
ATOM   3139 C  CG  . TRP A 1 440 ? -3.847  -48.394 -34.714 1.00 43.48  ? 703  TRP A CG  1 
ATOM   3140 C  CD1 . TRP A 1 440 ? -3.315  -48.978 -35.831 1.00 41.28  ? 703  TRP A CD1 1 
ATOM   3141 C  CD2 . TRP A 1 440 ? -5.000  -49.179 -34.376 1.00 40.88  ? 703  TRP A CD2 1 
ATOM   3142 N  NE1 . TRP A 1 440 ? -4.045  -50.080 -36.195 1.00 41.61  ? 703  TRP A NE1 1 
ATOM   3143 C  CE2 . TRP A 1 440 ? -5.071  -50.241 -35.308 1.00 42.99  ? 703  TRP A CE2 1 
ATOM   3144 C  CE3 . TRP A 1 440 ? -5.966  -49.092 -33.374 1.00 42.85  ? 703  TRP A CE3 1 
ATOM   3145 C  CZ2 . TRP A 1 440 ? -6.088  -51.197 -35.271 1.00 45.39  ? 703  TRP A CZ2 1 
ATOM   3146 C  CZ3 . TRP A 1 440 ? -6.971  -50.039 -33.337 1.00 44.52  ? 703  TRP A CZ3 1 
ATOM   3147 C  CH2 . TRP A 1 440 ? -7.032  -51.072 -34.280 1.00 43.88  ? 703  TRP A CH2 1 
ATOM   3148 N  N   . THR A 1 441 ? -2.773  -49.589 -31.629 1.00 34.34  ? 704  THR A N   1 
ATOM   3149 C  CA  . THR A 1 441 ? -3.353  -50.522 -30.624 1.00 33.03  ? 704  THR A CA  1 
ATOM   3150 C  C   . THR A 1 441 ? -2.650  -50.386 -29.276 1.00 33.61  ? 704  THR A C   1 
ATOM   3151 O  O   . THR A 1 441 ? -3.059  -51.065 -28.321 1.00 34.47  ? 704  THR A O   1 
ATOM   3152 C  CB  . THR A 1 441 ? -3.279  -51.972 -31.113 1.00 32.57  ? 704  THR A CB  1 
ATOM   3153 O  OG1 . THR A 1 441 ? -1.911  -52.342 -31.214 1.00 38.93  ? 704  THR A OG1 1 
ATOM   3154 C  CG2 . THR A 1 441 ? -3.959  -52.185 -32.444 1.00 32.48  ? 704  THR A CG2 1 
ATOM   3155 N  N   . GLN A 1 442 ? -1.649  -49.516 -29.170 1.00 36.22  ? 705  GLN A N   1 
ATOM   3156 C  CA  . GLN A 1 442 ? -0.957  -49.200 -27.891 1.00 36.70  ? 705  GLN A CA  1 
ATOM   3157 C  C   . GLN A 1 442 ? -1.280  -47.791 -27.369 1.00 34.32  ? 705  GLN A C   1 
ATOM   3158 O  O   . GLN A 1 442 ? -1.035  -47.535 -26.181 1.00 31.57  ? 705  GLN A O   1 
ATOM   3159 C  CB  . GLN A 1 442 ? 0.541   -49.246 -28.153 1.00 43.41  ? 705  GLN A CB  1 
ATOM   3160 C  CG  . GLN A 1 442 ? 0.913   -50.425 -29.008 1.00 46.60  ? 705  GLN A CG  1 
ATOM   3161 C  CD  . GLN A 1 442 ? 0.977   -51.617 -28.109 1.00 51.36  ? 705  GLN A CD  1 
ATOM   3162 O  OE1 . GLN A 1 442 ? 1.935   -51.732 -27.349 1.00 47.22  ? 705  GLN A OE1 1 
ATOM   3163 N  NE2 . GLN A 1 442 ? 0.005   -52.516 -28.239 1.00 59.54  ? 705  GLN A NE2 1 
ATOM   3164 N  N   . VAL A 1 443 ? -1.767  -46.902 -28.219 1.00 31.84  ? 706  VAL A N   1 
ATOM   3165 C  CA  . VAL A 1 443 ? -2.040  -45.482 -27.857 1.00 37.00  ? 706  VAL A CA  1 
ATOM   3166 C  C   . VAL A 1 443 ? -3.103  -45.490 -26.769 1.00 32.10  ? 706  VAL A C   1 
ATOM   3167 O  O   . VAL A 1 443 ? -4.127  -46.113 -26.953 1.00 28.97  ? 706  VAL A O   1 
ATOM   3168 C  CB  . VAL A 1 443 ? -2.546  -44.693 -29.081 1.00 35.69  ? 706  VAL A CB  1 
ATOM   3169 C  CG1 . VAL A 1 443 ? -2.922  -43.273 -28.723 1.00 44.03  ? 706  VAL A CG1 1 
ATOM   3170 C  CG2 . VAL A 1 443 ? -1.528  -44.701 -30.180 1.00 45.81  ? 706  VAL A CG2 1 
ATOM   3171 N  N   . PRO A 1 444 ? -2.943  -44.776 -25.646 1.00 28.39  ? 707  PRO A N   1 
ATOM   3172 C  CA  . PRO A 1 444 ? -4.056  -44.588 -24.718 1.00 29.07  ? 707  PRO A CA  1 
ATOM   3173 C  C   . PRO A 1 444 ? -4.999  -43.453 -25.174 1.00 29.39  ? 707  PRO A C   1 
ATOM   3174 O  O   . PRO A 1 444 ? -4.516  -42.421 -25.611 1.00 29.94  ? 707  PRO A O   1 
ATOM   3175 C  CB  . PRO A 1 444 ? -3.366  -44.168 -23.423 1.00 30.31  ? 707  PRO A CB  1 
ATOM   3176 C  CG  . PRO A 1 444 ? -2.103  -43.453 -23.897 1.00 31.90  ? 707  PRO A CG  1 
ATOM   3177 C  CD  . PRO A 1 444 ? -1.741  -44.044 -25.261 1.00 29.70  ? 707  PRO A CD  1 
ATOM   3178 N  N   . PHE A 1 445 ? -6.314  -43.615 -24.986 1.00 28.06  ? 708  PHE A N   1 
ATOM   3179 C  CA  . PHE A 1 445 ? -7.324  -42.572 -25.296 1.00 27.33  ? 708  PHE A CA  1 
ATOM   3180 C  C   . PHE A 1 445 ? -8.605  -42.867 -24.519 1.00 29.80  ? 708  PHE A C   1 
ATOM   3181 O  O   . PHE A 1 445 ? -9.039  -44.026 -24.597 1.00 26.13  ? 708  PHE A O   1 
ATOM   3182 C  CB  . PHE A 1 445 ? -7.624  -42.550 -26.803 1.00 31.71  ? 708  PHE A CB  1 
ATOM   3183 C  CG  . PHE A 1 445 ? -8.491  -41.405 -27.288 1.00 32.70  ? 708  PHE A CG  1 
ATOM   3184 C  CD1 . PHE A 1 445 ? -8.211  -40.086 -26.931 1.00 34.29  ? 708  PHE A CD1 1 
ATOM   3185 C  CD2 . PHE A 1 445 ? -9.532  -41.627 -28.185 1.00 37.82  ? 708  PHE A CD2 1 
ATOM   3186 C  CE1 . PHE A 1 445 ? -8.975  -39.027 -27.416 1.00 36.02  ? 708  PHE A CE1 1 
ATOM   3187 C  CE2 . PHE A 1 445 ? -10.302 -40.566 -28.674 1.00 37.95  ? 708  PHE A CE2 1 
ATOM   3188 C  CZ  . PHE A 1 445 ? -10.043 -39.272 -28.257 1.00 36.55  ? 708  PHE A CZ  1 
ATOM   3189 N  N   . CYS A 1 446 ? -9.105  -41.881 -23.760 1.00 29.50  ? 709  CYS A N   1 
ATOM   3190 C  CA  . CYS A 1 446 ? -10.356 -41.917 -22.947 1.00 31.71  ? 709  CYS A CA  1 
ATOM   3191 C  C   . CYS A 1 446 ? -10.277 -43.097 -21.974 1.00 30.13  ? 709  CYS A C   1 
ATOM   3192 O  O   . CYS A 1 446 ? -11.264 -43.839 -21.858 1.00 34.41  ? 709  CYS A O   1 
ATOM   3193 C  CB  . CYS A 1 446 ? -11.582 -41.935 -23.842 1.00 32.49  ? 709  CYS A CB  1 
ATOM   3194 S  SG  . CYS A 1 446 ? -11.670 -40.456 -24.898 1.00 38.10  ? 709  CYS A SG  1 
ATOM   3195 N  N   . SER A 1 447 ? -9.095  -43.296 -21.386 1.00 27.58  ? 710  SER A N   1 
ATOM   3196 C  CA  . SER A 1 447 ? -8.812  -44.308 -20.344 1.00 30.38  ? 710  SER A CA  1 
ATOM   3197 C  C   . SER A 1 447 ? -8.816  -45.706 -20.976 1.00 31.53  ? 710  SER A C   1 
ATOM   3198 O  O   . SER A 1 447 ? -8.851  -46.700 -20.215 1.00 30.83  ? 710  SER A O   1 
ATOM   3199 C  CB  . SER A 1 447 ? -9.827  -44.218 -19.240 1.00 35.80  ? 710  SER A CB  1 
ATOM   3200 O  OG  . SER A 1 447 ? -9.783  -42.954 -18.601 1.00 40.83  ? 710  SER A OG  1 
ATOM   3201 N  N   . HIS A 1 448 ? -8.768  -45.807 -22.305 1.00 28.73  ? 711  HIS A N   1 
ATOM   3202 C  CA  . HIS A 1 448 ? -8.806  -47.131 -22.982 1.00 29.60  ? 711  HIS A CA  1 
ATOM   3203 C  C   . HIS A 1 448 ? -7.616  -47.340 -23.918 1.00 32.45  ? 711  HIS A C   1 
ATOM   3204 O  O   . HIS A 1 448 ? -6.904  -46.345 -24.236 1.00 26.47  ? 711  HIS A O   1 
ATOM   3205 C  CB  . HIS A 1 448 ? -10.081 -47.280 -23.788 1.00 30.37  ? 711  HIS A CB  1 
ATOM   3206 C  CG  . HIS A 1 448 ? -11.287 -47.494 -22.930 1.00 31.76  ? 711  HIS A CG  1 
ATOM   3207 N  ND1 . HIS A 1 448 ? -11.845 -46.475 -22.187 1.00 31.33  ? 711  HIS A ND1 1 
ATOM   3208 C  CD2 . HIS A 1 448 ? -11.982 -48.617 -22.638 1.00 32.32  ? 711  HIS A CD2 1 
ATOM   3209 C  CE1 . HIS A 1 448 ? -12.872 -46.955 -21.513 1.00 35.38  ? 711  HIS A CE1 1 
ATOM   3210 N  NE2 . HIS A 1 448 ? -12.993 -48.269 -21.771 1.00 32.58  ? 711  HIS A NE2 1 
ATOM   3211 N  N   . HIS A 1 449 ? -7.426  -48.601 -24.341 1.00 29.93  ? 712  HIS A N   1 
ATOM   3212 C  CA  . HIS A 1 449 ? -6.675  -48.973 -25.561 1.00 29.82  ? 712  HIS A CA  1 
ATOM   3213 C  C   . HIS A 1 449 ? -7.619  -49.825 -26.420 1.00 31.02  ? 712  HIS A C   1 
ATOM   3214 O  O   . HIS A 1 449 ? -8.655  -50.246 -25.927 1.00 30.79  ? 712  HIS A O   1 
ATOM   3215 C  CB  . HIS A 1 449 ? -5.325  -49.661 -25.208 1.00 27.88  ? 712  HIS A CB  1 
ATOM   3216 C  CG  . HIS A 1 449 ? -5.508  -50.910 -24.409 1.00 26.50  ? 712  HIS A CG  1 
ATOM   3217 N  ND1 . HIS A 1 449 ? -5.661  -50.890 -23.031 1.00 24.15  ? 712  HIS A ND1 1 
ATOM   3218 C  CD2 . HIS A 1 449 ? -5.631  -52.199 -24.788 1.00 24.72  ? 712  HIS A CD2 1 
ATOM   3219 C  CE1 . HIS A 1 449 ? -5.851  -52.129 -22.590 1.00 25.72  ? 712  HIS A CE1 1 
ATOM   3220 N  NE2 . HIS A 1 449 ? -5.819  -52.954 -23.654 1.00 26.84  ? 712  HIS A NE2 1 
ATOM   3221 N  N   . PHE A 1 450 ? -7.187  -50.163 -27.625 1.00 29.71  ? 713  PHE A N   1 
ATOM   3222 C  CA  . PHE A 1 450 ? -8.051  -50.777 -28.637 1.00 31.00  ? 713  PHE A CA  1 
ATOM   3223 C  C   . PHE A 1 450 ? -7.319  -51.963 -29.247 1.00 30.69  ? 713  PHE A C   1 
ATOM   3224 O  O   . PHE A 1 450 ? -6.185  -51.811 -29.645 1.00 30.52  ? 713  PHE A O   1 
ATOM   3225 C  CB  . PHE A 1 450 ? -8.509  -49.679 -29.600 1.00 31.09  ? 713  PHE A CB  1 
ATOM   3226 C  CG  . PHE A 1 450 ? -9.208  -48.569 -28.857 1.00 30.70  ? 713  PHE A CG  1 
ATOM   3227 C  CD1 . PHE A 1 450 ? -8.493  -47.526 -28.296 1.00 34.72  ? 713  PHE A CD1 1 
ATOM   3228 C  CD2 . PHE A 1 450 ? -10.566 -48.628 -28.612 1.00 33.06  ? 713  PHE A CD2 1 
ATOM   3229 C  CE1 . PHE A 1 450 ? -9.147  -46.521 -27.591 1.00 36.18  ? 713  PHE A CE1 1 
ATOM   3230 C  CE2 . PHE A 1 450 ? -11.200 -47.639 -27.876 1.00 33.88  ? 713  PHE A CE2 1 
ATOM   3231 C  CZ  . PHE A 1 450 ? -10.497 -46.587 -27.372 1.00 32.33  ? 713  PHE A CZ  1 
ATOM   3232 N  N   . HIS A 1 451 ? -7.988  -53.111 -29.283 1.00 31.88  ? 714  HIS A N   1 
ATOM   3233 C  CA  . HIS A 1 451 ? -7.502  -54.336 -29.932 1.00 33.89  ? 714  HIS A CA  1 
ATOM   3234 C  C   . HIS A 1 451 ? -8.187  -54.502 -31.283 1.00 34.09  ? 714  HIS A C   1 
ATOM   3235 O  O   . HIS A 1 451 ? -9.364  -54.136 -31.398 1.00 34.90  ? 714  HIS A O   1 
ATOM   3236 C  CB  . HIS A 1 451 ? -7.777  -55.523 -29.012 1.00 32.01  ? 714  HIS A CB  1 
ATOM   3237 C  CG  . HIS A 1 451 ? -7.086  -55.504 -27.677 1.00 31.26  ? 714  HIS A CG  1 
ATOM   3238 N  ND1 . HIS A 1 451 ? -6.010  -56.287 -27.392 1.00 32.03  ? 714  HIS A ND1 1 
ATOM   3239 C  CD2 . HIS A 1 451 ? -7.379  -54.874 -26.518 1.00 33.92  ? 714  HIS A CD2 1 
ATOM   3240 C  CE1 . HIS A 1 451 ? -5.677  -56.120 -26.119 1.00 34.94  ? 714  HIS A CE1 1 
ATOM   3241 N  NE2 . HIS A 1 451 ? -6.476  -55.235 -25.570 1.00 22.73  ? 714  HIS A NE2 1 
ATOM   3242 N  N   . GLU A 1 452 ? -7.468  -54.997 -32.299 0.50 37.12  ? 715  GLU A N   1 
ATOM   3243 C  CA  . GLU A 1 452 ? -8.032  -55.296 -33.649 0.50 37.70  ? 715  GLU A CA  1 
ATOM   3244 C  C   . GLU A 1 452 ? -8.364  -56.792 -33.722 0.50 38.92  ? 715  GLU A C   1 
ATOM   3245 O  O   . GLU A 1 452 ? -7.487  -57.568 -34.099 0.50 38.51  ? 715  GLU A O   1 
ATOM   3246 C  CB  . GLU A 1 452 ? -7.080  -54.877 -34.778 0.50 37.80  ? 715  GLU A CB  1 
ATOM   3247 C  CG  . GLU A 1 452 ? -7.795  -54.690 -36.112 0.50 38.22  ? 715  GLU A CG  1 
ATOM   3248 C  CD  . GLU A 1 452 ? -7.028  -54.031 -37.252 0.50 39.09  ? 715  GLU A CD  1 
ATOM   3249 O  OE1 . GLU A 1 452 ? -7.687  -53.473 -38.169 0.50 36.43  ? 715  GLU A OE1 1 
ATOM   3250 O  OE2 . GLU A 1 452 ? -5.779  -54.087 -37.242 0.50 41.88  ? 715  GLU A OE2 1 
ATOM   3251 N  N   . LEU A 1 453 ? -9.605  -57.160 -33.392 0.50 40.48  ? 716  LEU A N   1 
ATOM   3252 C  CA  . LEU A 1 453 ? -10.061 -58.563 -33.206 0.50 42.99  ? 716  LEU A CA  1 
ATOM   3253 C  C   . LEU A 1 453 ? -10.654 -59.097 -34.519 0.50 42.62  ? 716  LEU A C   1 
ATOM   3254 O  O   . LEU A 1 453 ? -11.318 -58.323 -35.237 0.50 41.11  ? 716  LEU A O   1 
ATOM   3255 C  CB  . LEU A 1 453 ? -11.088 -58.566 -32.071 0.50 46.01  ? 716  LEU A CB  1 
ATOM   3256 C  CG  . LEU A 1 453 ? -11.541 -59.932 -31.570 0.50 49.64  ? 716  LEU A CG  1 
ATOM   3257 C  CD1 . LEU A 1 453 ? -10.349 -60.825 -31.281 0.50 51.96  ? 716  LEU A CD1 1 
ATOM   3258 C  CD2 . LEU A 1 453 ? -12.407 -59.784 -30.327 0.50 52.82  ? 716  LEU A CD2 1 
ATOM   3259 N  N   . ILE A 1 454 ? -10.418 -60.374 -34.822 0.50 43.76  ? 717  ILE A N   1 
ATOM   3260 C  CA  . ILE A 1 454 ? -10.860 -61.031 -36.091 0.50 45.06  ? 717  ILE A CA  1 
ATOM   3261 C  C   . ILE A 1 454 ? -11.923 -62.083 -35.763 0.50 43.86  ? 717  ILE A C   1 
ATOM   3262 O  O   . ILE A 1 454 ? -11.641 -62.969 -34.926 0.50 42.88  ? 717  ILE A O   1 
ATOM   3263 C  CB  . ILE A 1 454 ? -9.654  -61.643 -36.830 0.50 50.16  ? 717  ILE A CB  1 
ATOM   3264 C  CG1 . ILE A 1 454 ? -8.517  -60.627 -36.979 0.50 49.73  ? 717  ILE A CG1 1 
ATOM   3265 C  CG2 . ILE A 1 454 ? -10.080 -62.219 -38.174 0.50 51.17  ? 717  ILE A CG2 1 
ATOM   3266 C  CD1 . ILE A 1 454 ? -7.347  -61.129 -37.784 0.50 50.84  ? 717  ILE A CD1 1 
ATOM   3267 N  N   . MET A 1 455 ? -13.111 -61.982 -36.367 1.00 42.14  ? 718  MET A N   1 
ATOM   3268 C  CA  . MET A 1 455 ? -14.190 -62.973 -36.101 1.00 49.75  ? 718  MET A CA  1 
ATOM   3269 C  C   . MET A 1 455 ? -13.926 -64.230 -36.928 1.00 46.74  ? 718  MET A C   1 
ATOM   3270 O  O   . MET A 1 455 ? -13.274 -64.140 -37.985 1.00 44.99  ? 718  MET A O   1 
ATOM   3271 C  CB  . MET A 1 455 ? -15.567 -62.423 -36.470 1.00 49.03  ? 718  MET A CB  1 
ATOM   3272 C  CG  . MET A 1 455 ? -15.892 -61.137 -35.760 1.00 57.21  ? 718  MET A CG  1 
ATOM   3273 S  SD  . MET A 1 455 ? -17.444 -60.426 -36.349 1.00 51.68  ? 718  MET A SD  1 
ATOM   3274 C  CE  . MET A 1 455 ? -18.548 -61.646 -35.652 1.00 48.09  ? 718  MET A CE  1 
ATOM   3275 N  N   A LYS A 1 456 ? -14.420 -65.370 -36.436 0.25 46.09  ? 719  LYS A N   1 
ATOM   3276 N  N   B LYS A 1 456 ? -14.439 -65.369 -36.460 0.25 47.22  ? 719  LYS A N   1 
ATOM   3277 C  CA  A LYS A 1 456 ? -14.341 -66.701 -37.097 0.25 48.29  ? 719  LYS A CA  1 
ATOM   3278 C  CA  B LYS A 1 456 ? -14.259 -66.692 -37.112 0.25 50.25  ? 719  LYS A CA  1 
ATOM   3279 C  C   A LYS A 1 456 ? -14.565 -66.538 -38.606 0.25 48.86  ? 719  LYS A C   1 
ATOM   3280 C  C   B LYS A 1 456 ? -14.590 -66.567 -38.609 0.25 50.06  ? 719  LYS A C   1 
ATOM   3281 O  O   A LYS A 1 456 ? -13.928 -67.267 -39.387 0.25 50.79  ? 719  LYS A O   1 
ATOM   3282 O  O   B LYS A 1 456 ? -14.040 -67.355 -39.397 0.25 52.10  ? 719  LYS A O   1 
ATOM   3283 C  CB  A LYS A 1 456 ? -15.377 -67.648 -36.482 0.25 48.74  ? 719  LYS A CB  1 
ATOM   3284 C  CB  B LYS A 1 456 ? -15.097 -67.757 -36.395 0.25 52.23  ? 719  LYS A CB  1 
ATOM   3285 C  CG  A LYS A 1 456 ? -14.976 -68.258 -35.147 0.25 49.16  ? 719  LYS A CG  1 
ATOM   3286 C  CG  B LYS A 1 456 ? -14.810 -69.185 -36.842 0.25 54.65  ? 719  LYS A CG  1 
ATOM   3287 C  CD  A LYS A 1 456 ? -15.901 -69.358 -34.672 0.25 48.24  ? 719  LYS A CD  1 
ATOM   3288 C  CD  B LYS A 1 456 ? -15.040 -70.265 -35.798 0.25 53.42  ? 719  LYS A CD  1 
ATOM   3289 C  CE  A LYS A 1 456 ? -17.284 -68.867 -34.303 0.25 48.16  ? 719  LYS A CE  1 
ATOM   3290 C  CE  B LYS A 1 456 ? -15.156 -71.648 -36.412 0.25 52.85  ? 719  LYS A CE  1 
ATOM   3291 N  NZ  A LYS A 1 456 ? -17.997 -69.852 -33.458 0.25 45.66  ? 719  LYS A NZ  1 
ATOM   3292 N  NZ  B LYS A 1 456 ? -14.819 -72.721 -35.448 0.25 51.60  ? 719  LYS A NZ  1 
ATOM   3293 N  N   . ASP A 1 457 ? -15.415 -65.586 -38.993 1.00 48.43  ? 720  ASP A N   1 
ATOM   3294 C  CA  . ASP A 1 457 ? -15.807 -65.351 -40.422 1.00 50.99  ? 720  ASP A CA  1 
ATOM   3295 C  C   . ASP A 1 457 ? -14.978 -64.253 -41.115 1.00 53.28  ? 720  ASP A C   1 
ATOM   3296 O  O   . ASP A 1 457 ? -15.423 -63.835 -42.204 1.00 46.53  ? 720  ASP A O   1 
ATOM   3297 C  CB  . ASP A 1 457 ? -17.296 -64.979 -40.521 1.00 54.41  ? 720  ASP A CB  1 
ATOM   3298 C  CG  . ASP A 1 457 ? -17.703 -63.709 -39.781 1.00 61.50  ? 720  ASP A CG  1 
ATOM   3299 O  OD1 . ASP A 1 457 ? -17.003 -62.676 -39.943 1.00 66.67  ? 720  ASP A OD1 1 
ATOM   3300 O  OD2 . ASP A 1 457 ? -18.724 -63.752 -39.056 1.00 66.98  ? 720  ASP A OD2 1 
ATOM   3301 N  N   . GLY A 1 458 ? -13.906 -63.735 -40.481 1.00 52.32  ? 721  GLY A N   1 
ATOM   3302 C  CA  . GLY A 1 458 ? -12.932 -62.800 -41.081 1.00 52.63  ? 721  GLY A CA  1 
ATOM   3303 C  C   . GLY A 1 458 ? -13.346 -61.338 -40.970 1.00 48.75  ? 721  GLY A C   1 
ATOM   3304 O  O   . GLY A 1 458 ? -12.545 -60.473 -41.254 1.00 50.88  ? 721  GLY A O   1 
ATOM   3305 N  N   . ARG A 1 459 ? -14.561 -61.029 -40.541 1.00 49.63  ? 722  ARG A N   1 
ATOM   3306 C  CA  . ARG A 1 459 ? -14.915 -59.613 -40.288 1.00 45.71  ? 722  ARG A CA  1 
ATOM   3307 C  C   . ARG A 1 459 ? -14.093 -59.086 -39.094 1.00 46.40  ? 722  ARG A C   1 
ATOM   3308 O  O   . ARG A 1 459 ? -13.686 -59.854 -38.175 1.00 42.97  ? 722  ARG A O   1 
ATOM   3309 C  CB  . ARG A 1 459 ? -16.427 -59.481 -40.113 1.00 49.41  ? 722  ARG A CB  1 
ATOM   3310 C  CG  . ARG A 1 459 ? -17.230 -59.837 -41.361 1.00 48.50  ? 722  ARG A CG  1 
ATOM   3311 C  CD  . ARG A 1 459 ? -18.721 -59.538 -41.200 1.00 45.79  ? 722  ARG A CD  1 
ATOM   3312 N  NE  . ARG A 1 459 ? -19.327 -60.429 -40.228 1.00 42.96  ? 722  ARG A NE  1 
ATOM   3313 C  CZ  . ARG A 1 459 ? -20.609 -60.441 -39.908 1.00 50.60  ? 722  ARG A CZ  1 
ATOM   3314 N  NH1 . ARG A 1 459 ? -21.449 -59.604 -40.503 1.00 53.23  ? 722  ARG A NH1 1 
ATOM   3315 N  NH2 . ARG A 1 459 ? -21.043 -61.304 -38.997 1.00 50.84  ? 722  ARG A NH2 1 
ATOM   3316 N  N   . VAL A 1 460 ? -13.867 -57.788 -39.099 1.00 45.76  ? 723  VAL A N   1 
ATOM   3317 C  CA  . VAL A 1 460 ? -12.901 -57.147 -38.178 1.00 44.23  ? 723  VAL A CA  1 
ATOM   3318 C  C   . VAL A 1 460 ? -13.662 -56.241 -37.222 1.00 42.16  ? 723  VAL A C   1 
ATOM   3319 O  O   . VAL A 1 460 ? -14.331 -55.293 -37.667 1.00 49.59  ? 723  VAL A O   1 
ATOM   3320 C  CB  . VAL A 1 460 ? -11.808 -56.444 -38.980 1.00 52.31  ? 723  VAL A CB  1 
ATOM   3321 C  CG1 . VAL A 1 460 ? -10.680 -55.975 -38.085 1.00 62.06  ? 723  VAL A CG1 1 
ATOM   3322 C  CG2 . VAL A 1 460 ? -11.260 -57.405 -40.023 1.00 56.10  ? 723  VAL A CG2 1 
ATOM   3323 N  N   . LEU A 1 461 ? -13.604 -56.603 -35.951 1.00 38.84  ? 724  LEU A N   1 
ATOM   3324 C  CA  . LEU A 1 461 ? -14.004 -55.764 -34.806 1.00 36.48  ? 724  LEU A CA  1 
ATOM   3325 C  C   . LEU A 1 461 ? -12.770 -54.983 -34.327 1.00 39.57  ? 724  LEU A C   1 
ATOM   3326 O  O   . LEU A 1 461 ? -11.661 -55.562 -34.217 1.00 39.00  ? 724  LEU A O   1 
ATOM   3327 C  CB  . LEU A 1 461 ? -14.538 -56.699 -33.724 1.00 38.45  ? 724  LEU A CB  1 
ATOM   3328 C  CG  . LEU A 1 461 ? -15.726 -57.558 -34.173 1.00 35.36  ? 724  LEU A CG  1 
ATOM   3329 C  CD1 . LEU A 1 461 ? -16.047 -58.596 -33.134 1.00 35.97  ? 724  LEU A CD1 1 
ATOM   3330 C  CD2 . LEU A 1 461 ? -16.931 -56.709 -34.451 1.00 33.25  ? 724  LEU A CD2 1 
ATOM   3331 N  N   . VAL A 1 462 ? -12.955 -53.705 -34.051 1.00 35.14  ? 725  VAL A N   1 
ATOM   3332 C  CA  . VAL A 1 462 ? -12.020 -52.892 -33.250 1.00 32.10  ? 725  VAL A CA  1 
ATOM   3333 C  C   . VAL A 1 462 ? -12.698 -52.602 -31.922 1.00 29.48  ? 725  VAL A C   1 
ATOM   3334 O  O   . VAL A 1 462 ? -13.704 -51.878 -31.929 1.00 34.09  ? 725  VAL A O   1 
ATOM   3335 C  CB  . VAL A 1 462 ? -11.588 -51.615 -33.979 1.00 32.66  ? 725  VAL A CB  1 
ATOM   3336 C  CG1 . VAL A 1 462 ? -10.718 -50.756 -33.056 1.00 34.48  ? 725  VAL A CG1 1 
ATOM   3337 C  CG2 . VAL A 1 462 ? -10.832 -51.981 -35.241 1.00 31.71  ? 725  VAL A CG2 1 
ATOM   3338 N  N   . VAL A 1 463 ? -12.142 -53.138 -30.841 1.00 28.85  ? 726  VAL A N   1 
ATOM   3339 C  CA  . VAL A 1 463 ? -12.842 -53.254 -29.535 1.00 28.10  ? 726  VAL A CA  1 
ATOM   3340 C  C   . VAL A 1 463 ? -12.097 -52.453 -28.479 1.00 29.41  ? 726  VAL A C   1 
ATOM   3341 O  O   . VAL A 1 463 ? -10.866 -52.371 -28.454 1.00 31.15  ? 726  VAL A O   1 
ATOM   3342 C  CB  . VAL A 1 463 ? -12.985 -54.726 -29.134 1.00 29.65  ? 726  VAL A CB  1 
ATOM   3343 C  CG1 . VAL A 1 463 ? -13.868 -55.435 -30.145 1.00 30.53  ? 726  VAL A CG1 1 
ATOM   3344 C  CG2 . VAL A 1 463 ? -11.621 -55.418 -29.010 1.00 30.49  ? 726  VAL A CG2 1 
ATOM   3345 N  N   . PRO A 1 464 ? -12.824 -51.811 -27.566 1.00 28.18  ? 727  PRO A N   1 
ATOM   3346 C  CA  . PRO A 1 464 ? -12.184 -51.037 -26.508 1.00 27.93  ? 727  PRO A CA  1 
ATOM   3347 C  C   . PRO A 1 464 ? -11.821 -51.985 -25.372 1.00 31.07  ? 727  PRO A C   1 
ATOM   3348 O  O   . PRO A 1 464 ? -12.500 -53.006 -25.208 1.00 26.01  ? 727  PRO A O   1 
ATOM   3349 C  CB  . PRO A 1 464 ? -13.326 -50.110 -26.070 1.00 28.03  ? 727  PRO A CB  1 
ATOM   3350 C  CG  . PRO A 1 464 ? -14.532 -51.040 -26.189 1.00 28.86  ? 727  PRO A CG  1 
ATOM   3351 C  CD  . PRO A 1 464 ? -14.292 -51.765 -27.506 1.00 29.62  ? 727  PRO A CD  1 
ATOM   3352 N  N   . CYS A 1 465 ? -10.804 -51.591 -24.596 1.00 31.50  ? 728  CYS A N   1 
ATOM   3353 C  CA  . CYS A 1 465 ? -10.216 -52.424 -23.521 1.00 29.45  ? 728  CYS A CA  1 
ATOM   3354 C  C   . CYS A 1 465 ? -9.525  -51.537 -22.481 1.00 31.41  ? 728  CYS A C   1 
ATOM   3355 O  O   . CYS A 1 465 ? -9.055  -50.449 -22.817 1.00 28.38  ? 728  CYS A O   1 
ATOM   3356 C  CB  . CYS A 1 465 ? -9.184  -53.399 -24.082 1.00 29.17  ? 728  CYS A CB  1 
ATOM   3357 S  SG  . CYS A 1 465 ? -8.783  -54.756 -22.939 1.00 30.03  ? 728  CYS A SG  1 
ATOM   3358 N  N   . ARG A 1 466 ? -9.498  -52.005 -21.232 0.50 30.98  ? 729  ARG A N   1 
ATOM   3359 C  CA  . ARG A 1 466 ? -8.659  -51.446 -20.151 0.50 32.23  ? 729  ARG A CA  1 
ATOM   3360 C  C   . ARG A 1 466 ? -8.407  -52.539 -19.108 0.50 31.68  ? 729  ARG A C   1 
ATOM   3361 O  O   . ARG A 1 466 ? -8.986  -53.633 -19.228 0.50 30.73  ? 729  ARG A O   1 
ATOM   3362 C  CB  . ARG A 1 466 ? -9.288  -50.177 -19.572 0.50 33.99  ? 729  ARG A CB  1 
ATOM   3363 C  CG  . ARG A 1 466 ? -10.716 -50.331 -19.082 0.50 35.68  ? 729  ARG A CG  1 
ATOM   3364 C  CD  . ARG A 1 466 ? -11.282 -48.999 -18.612 0.50 36.01  ? 729  ARG A CD  1 
ATOM   3365 N  NE  . ARG A 1 466 ? -10.495 -48.435 -17.530 0.50 35.99  ? 729  ARG A NE  1 
ATOM   3366 C  CZ  . ARG A 1 466 ? -10.762 -47.293 -16.916 0.50 38.43  ? 729  ARG A CZ  1 
ATOM   3367 N  NH1 . ARG A 1 466 ? -11.820 -46.574 -17.260 0.50 40.86  ? 729  ARG A NH1 1 
ATOM   3368 N  NH2 . ARG A 1 466 ? -9.964  -46.868 -15.958 0.50 38.26  ? 729  ARG A NH2 1 
ATOM   3369 N  N   . ASN A 1 467 ? -7.512  -52.266 -18.159 1.00 33.25  ? 730  ASN A N   1 
ATOM   3370 C  CA  . ASN A 1 467 ? -7.133  -53.249 -17.127 1.00 35.41  ? 730  ASN A CA  1 
ATOM   3371 C  C   . ASN A 1 467 ? -8.431  -53.688 -16.439 1.00 29.94  ? 730  ASN A C   1 
ATOM   3372 O  O   . ASN A 1 467 ? -9.155  -52.850 -15.924 1.00 28.69  ? 730  ASN A O   1 
ATOM   3373 C  CB  . ASN A 1 467 ? -6.057  -52.721 -16.185 1.00 34.99  ? 730  ASN A CB  1 
ATOM   3374 C  CG  . ASN A 1 467 ? -5.827  -53.732 -15.088 1.00 38.01  ? 730  ASN A CG  1 
ATOM   3375 O  OD1 . ASN A 1 467 ? -6.509  -53.707 -14.093 1.00 35.09  ? 730  ASN A OD1 1 
ATOM   3376 N  ND2 . ASN A 1 467 ? -4.892  -54.647 -15.283 1.00 49.49  ? 730  ASN A ND2 1 
ATOM   3377 N  N   . GLN A 1 468 ? -8.666  -54.992 -16.440 1.00 28.83  ? 731  GLN A N   1 
ATOM   3378 C  CA  . GLN A 1 468 ? -9.919  -55.593 -15.966 1.00 31.34  ? 731  GLN A CA  1 
ATOM   3379 C  C   . GLN A 1 468 ? -10.134 -55.266 -14.496 1.00 31.01  ? 731  GLN A C   1 
ATOM   3380 O  O   . GLN A 1 468 ? -11.316 -55.189 -14.105 1.00 28.21  ? 731  GLN A O   1 
ATOM   3381 C  CB  . GLN A 1 468 ? -9.916  -57.084 -16.239 1.00 32.11  ? 731  GLN A CB  1 
ATOM   3382 C  CG  . GLN A 1 468 ? -11.269 -57.722 -16.033 1.00 30.74  ? 731  GLN A CG  1 
ATOM   3383 C  CD  . GLN A 1 468 ? -11.191 -59.210 -16.301 1.00 30.16  ? 731  GLN A CD  1 
ATOM   3384 O  OE1 . GLN A 1 468 ? -11.456 -59.671 -17.398 1.00 29.99  ? 731  GLN A OE1 1 
ATOM   3385 N  NE2 . GLN A 1 468 ? -10.845 -59.984 -15.290 1.00 31.53  ? 731  GLN A NE2 1 
ATOM   3386 N  N   . ASP A 1 469 ? -9.075  -55.052 -13.722 1.00 29.10  ? 732  ASP A N   1 
ATOM   3387 C  CA  . ASP A 1 469 ? -9.217  -54.665 -12.289 1.00 29.93  ? 732  ASP A CA  1 
ATOM   3388 C  C   . ASP A 1 469 ? -9.950  -53.332 -12.177 1.00 29.07  ? 732  ASP A C   1 
ATOM   3389 O  O   . ASP A 1 469 ? -10.746 -53.192 -11.224 1.00 33.32  ? 732  ASP A O   1 
ATOM   3390 C  CB  . ASP A 1 469 ? -7.893  -54.566 -11.554 1.00 29.53  ? 732  ASP A CB  1 
ATOM   3391 C  CG  . ASP A 1 469 ? -7.193  -55.911 -11.378 1.00 39.93  ? 732  ASP A CG  1 
ATOM   3392 O  OD1 . ASP A 1 469 ? -7.843  -56.975 -11.520 1.00 39.84  ? 732  ASP A OD1 1 
ATOM   3393 O  OD2 . ASP A 1 469 ? -5.993  -55.877 -11.089 1.00 44.34  ? 732  ASP A OD2 1 
ATOM   3394 N  N   . GLU A 1 470 ? -9.702  -52.408 -13.108 1.00 26.39  ? 733  GLU A N   1 
ATOM   3395 C  CA  . GLU A 1 470 ? -10.365 -51.083 -13.173 1.00 29.93  ? 733  GLU A CA  1 
ATOM   3396 C  C   . GLU A 1 470 ? -11.861 -51.279 -13.503 1.00 31.33  ? 733  GLU A C   1 
ATOM   3397 O  O   . GLU A 1 470 ? -12.689 -50.622 -12.835 1.00 32.00  ? 733  GLU A O   1 
ATOM   3398 C  CB  . GLU A 1 470 ? -9.702  -50.188 -14.227 1.00 33.22  ? 733  GLU A CB  1 
ATOM   3399 C  CG  . GLU A 1 470 ? -8.237  -49.838 -13.950 1.00 41.43  ? 733  GLU A CG  1 
ATOM   3400 C  CD  . GLU A 1 470 ? -7.468  -49.158 -15.083 1.00 44.33  ? 733  GLU A CD  1 
ATOM   3401 O  OE1 . GLU A 1 470 ? -6.206  -49.100 -15.019 1.00 57.09  ? 733  GLU A OE1 1 
ATOM   3402 O  OE2 . GLU A 1 470 ? -8.110  -48.713 -16.056 1.00 43.14  ? 733  GLU A OE2 1 
ATOM   3403 N  N   . LEU A 1 471 ? -12.204 -52.142 -14.470 1.00 28.89  ? 734  LEU A N   1 
ATOM   3404 C  CA  . LEU A 1 471 ? -13.610 -52.451 -14.842 1.00 25.65  ? 734  LEU A CA  1 
ATOM   3405 C  C   . LEU A 1 471 ? -14.359 -53.077 -13.658 1.00 28.21  ? 734  LEU A C   1 
ATOM   3406 O  O   . LEU A 1 471 ? -15.481 -52.596 -13.292 1.00 28.29  ? 734  LEU A O   1 
ATOM   3407 C  CB  . LEU A 1 471 ? -13.628 -53.325 -16.105 1.00 25.96  ? 734  LEU A CB  1 
ATOM   3408 C  CG  . LEU A 1 471 ? -13.080 -52.571 -17.318 1.00 30.71  ? 734  LEU A CG  1 
ATOM   3409 C  CD1 . LEU A 1 471 ? -13.054 -53.421 -18.587 1.00 29.59  ? 734  LEU A CD1 1 
ATOM   3410 C  CD2 . LEU A 1 471 ? -13.841 -51.291 -17.553 1.00 32.74  ? 734  LEU A CD2 1 
ATOM   3411 N  N   . ILE A 1 472 ? -13.796 -54.099 -13.037 1.00 27.52  ? 735  ILE A N   1 
ATOM   3412 C  CA  . ILE A 1 472 ? -14.517 -54.808 -11.945 1.00 29.38  ? 735  ILE A CA  1 
ATOM   3413 C  C   . ILE A 1 472 ? -14.631 -53.889 -10.721 1.00 30.55  ? 735  ILE A C   1 
ATOM   3414 O  O   . ILE A 1 472 ? -15.717 -53.881 -10.092 1.00 28.15  ? 735  ILE A O   1 
ATOM   3415 C  CB  . ILE A 1 472 ? -13.834 -56.145 -11.669 1.00 27.75  ? 735  ILE A CB  1 
ATOM   3416 C  CG1 . ILE A 1 472 ? -14.115 -57.055 -12.858 1.00 32.54  ? 735  ILE A CG1 1 
ATOM   3417 C  CG2 . ILE A 1 472 ? -14.336 -56.772 -10.367 1.00 29.31  ? 735  ILE A CG2 1 
ATOM   3418 C  CD1 . ILE A 1 472 ? -13.330 -58.334 -12.819 1.00 36.88  ? 735  ILE A CD1 1 
ATOM   3419 N  N   . GLY A 1 473 ? -13.563 -53.166 -10.373 1.00 26.13  ? 736  GLY A N   1 
ATOM   3420 C  CA  . GLY A 1 473 ? -13.567 -52.230 -9.235  1.00 31.32  ? 736  GLY A CA  1 
ATOM   3421 C  C   . GLY A 1 473 ? -14.625 -51.125 -9.400  1.00 33.47  ? 736  GLY A C   1 
ATOM   3422 O  O   . GLY A 1 473 ? -15.260 -50.748 -8.383  1.00 35.28  ? 736  GLY A O   1 
ATOM   3423 N  N   . ARG A 1 474 ? -14.861 -50.611 -10.612 1.00 29.14  ? 737  ARG A N   1 
ATOM   3424 C  CA  . ARG A 1 474 ? -15.865 -49.519 -10.820 1.00 31.40  ? 737  ARG A CA  1 
ATOM   3425 C  C   . ARG A 1 474 ? -17.290 -50.085 -10.690 1.00 28.21  ? 737  ARG A C   1 
ATOM   3426 O  O   . ARG A 1 474 ? -18.132 -49.425 -10.073 1.00 32.51  ? 737  ARG A O   1 
ATOM   3427 C  CB  . ARG A 1 474 ? -15.691 -48.837 -12.195 1.00 35.30  ? 737  ARG A CB  1 
ATOM   3428 C  CG  . ARG A 1 474 ? -14.268 -48.356 -12.472 1.00 54.72  ? 737  ARG A CG  1 
ATOM   3429 C  CD  . ARG A 1 474 ? -13.757 -48.327 -13.931 1.00 59.94  ? 737  ARG A CD  1 
ATOM   3430 N  NE  . ARG A 1 474 ? -14.286 -47.125 -14.546 1.00 73.10  ? 737  ARG A NE  1 
ATOM   3431 C  CZ  . ARG A 1 474 ? -13.963 -45.881 -14.174 1.00 73.24  ? 737  ARG A CZ  1 
ATOM   3432 N  NH1 . ARG A 1 474 ? -14.552 -44.858 -14.773 1.00 72.08  ? 737  ARG A NH1 1 
ATOM   3433 N  NH2 . ARG A 1 474 ? -13.038 -45.663 -13.247 1.00 66.27  ? 737  ARG A NH2 1 
ATOM   3434 N  N   . ALA A 1 475 ? -17.565 -51.258 -11.264 1.00 28.77  ? 738  ALA A N   1 
ATOM   3435 C  CA  . ALA A 1 475 ? -18.885 -51.921 -11.201 1.00 25.10  ? 738  ALA A CA  1 
ATOM   3436 C  C   . ALA A 1 475 ? -19.211 -52.280 -9.758  1.00 29.19  ? 738  ALA A C   1 
ATOM   3437 O  O   . ALA A 1 475 ? -20.383 -52.386 -9.463  1.00 30.47  ? 738  ALA A O   1 
ATOM   3438 C  CB  . ALA A 1 475 ? -18.901 -53.155 -12.047 1.00 22.54  ? 738  ALA A CB  1 
ATOM   3439 N  N   . ARG A 1 476 ? -18.232 -52.412 -8.864  1.00 32.22  ? 739  ARG A N   1 
ATOM   3440 C  CA  . ARG A 1 476 ? -18.535 -52.770 -7.444  1.00 32.61  ? 739  ARG A CA  1 
ATOM   3441 C  C   . ARG A 1 476 ? -18.888 -51.532 -6.628  1.00 32.29  ? 739  ARG A C   1 
ATOM   3442 O  O   . ARG A 1 476 ? -19.151 -51.659 -5.414  1.00 33.07  ? 739  ARG A O   1 
ATOM   3443 C  CB  . ARG A 1 476 ? -17.381 -53.569 -6.840  1.00 30.91  ? 739  ARG A CB  1 
ATOM   3444 C  CG  . ARG A 1 476 ? -17.415 -55.027 -7.274  1.00 30.85  ? 739  ARG A CG  1 
ATOM   3445 C  CD  . ARG A 1 476 ? -16.028 -55.712 -7.226  1.00 32.40  ? 739  ARG A CD  1 
ATOM   3446 N  NE  . ARG A 1 476 ? -15.565 -55.974 -5.868  1.00 30.86  ? 739  ARG A NE  1 
ATOM   3447 C  CZ  . ARG A 1 476 ? -15.324 -57.159 -5.331  1.00 28.48  ? 739  ARG A CZ  1 
ATOM   3448 N  NH1 . ARG A 1 476 ? -15.469 -58.263 -6.008  1.00 31.10  ? 739  ARG A NH1 1 
ATOM   3449 N  NH2 . ARG A 1 476 ? -14.854 -57.232 -4.110  1.00 32.08  ? 739  ARG A NH2 1 
ATOM   3450 N  N   . ILE A 1 477 ? -18.869 -50.369 -7.247  1.00 34.64  ? 740  ILE A N   1 
ATOM   3451 C  CA  . ILE A 1 477 ? -19.121 -49.107 -6.516  1.00 44.10  ? 740  ILE A CA  1 
ATOM   3452 C  C   . ILE A 1 477 ? -20.457 -48.500 -6.945  1.00 48.64  ? 740  ILE A C   1 
ATOM   3453 O  O   . ILE A 1 477 ? -20.763 -48.469 -8.142  1.00 40.96  ? 740  ILE A O   1 
ATOM   3454 C  CB  . ILE A 1 477 ? -17.981 -48.118 -6.751  1.00 48.05  ? 740  ILE A CB  1 
ATOM   3455 C  CG1 . ILE A 1 477 ? -16.713 -48.585 -6.023  1.00 48.21  ? 740  ILE A CG1 1 
ATOM   3456 C  CG2 . ILE A 1 477 ? -18.427 -46.725 -6.334  1.00 46.47  ? 740  ILE A CG2 1 
ATOM   3457 C  CD1 . ILE A 1 477 ? -15.459 -47.814 -6.396  1.00 48.16  ? 740  ILE A CD1 1 
ATOM   3458 N  N   A SER A 1 478 ? -21.212 -48.021 -5.955  0.25 53.61  ? 741  SER A N   1 
ATOM   3459 N  N   B SER A 1 478 ? -21.245 -48.045 -5.968  0.25 52.51  ? 741  SER A N   1 
ATOM   3460 C  CA  A SER A 1 478 ? -22.453 -47.217 -6.107  0.25 60.81  ? 741  SER A CA  1 
ATOM   3461 C  CA  B SER A 1 478 ? -22.458 -47.206 -6.173  0.25 58.78  ? 741  SER A CA  1 
ATOM   3462 C  C   A SER A 1 478 ? -22.241 -45.838 -5.466  0.25 65.15  ? 741  SER A C   1 
ATOM   3463 C  C   B SER A 1 478 ? -22.270 -45.853 -5.473  0.25 64.06  ? 741  SER A C   1 
ATOM   3464 O  O   A SER A 1 478 ? -21.668 -45.785 -4.354  0.25 67.83  ? 741  SER A O   1 
ATOM   3465 O  O   B SER A 1 478 ? -21.754 -45.834 -4.333  0.25 67.22  ? 741  SER A O   1 
ATOM   3466 C  CB  A SER A 1 478 ? -23.628 -47.944 -5.500  0.25 59.51  ? 741  SER A CB  1 
ATOM   3467 C  CB  B SER A 1 478 ? -23.720 -47.909 -5.716  0.25 56.31  ? 741  SER A CB  1 
ATOM   3468 O  OG  A SER A 1 478 ? -24.732 -47.074 -5.322  0.25 61.28  ? 741  SER A OG  1 
ATOM   3469 O  OG  B SER A 1 478 ? -23.465 -48.798 -4.640  0.25 54.86  ? 741  SER A OG  1 
ATOM   3470 N  N   . GLN A 1 479 ? -22.655 -44.767 -6.152  1.00 68.69  ? 742  GLN A N   1 
ATOM   3471 C  CA  . GLN A 1 479 ? -22.657 -43.387 -5.581  1.00 79.51  ? 742  GLN A CA  1 
ATOM   3472 C  C   . GLN A 1 479 ? -24.033 -43.127 -4.948  1.00 80.09  ? 742  GLN A C   1 
ATOM   3473 O  O   . GLN A 1 479 ? -25.045 -43.410 -5.628  1.00 70.35  ? 742  GLN A O   1 
ATOM   3474 C  CB  . GLN A 1 479 ? -22.364 -42.334 -6.658  1.00 88.06  ? 742  GLN A CB  1 
ATOM   3475 C  CG  . GLN A 1 479 ? -21.111 -42.611 -7.483  1.00 100.57 ? 742  GLN A CG  1 
ATOM   3476 C  CD  . GLN A 1 479 ? -19.860 -42.911 -6.680  1.00 109.67 ? 742  GLN A CD  1 
ATOM   3477 O  OE1 . GLN A 1 479 ? -19.772 -42.675 -5.470  1.00 106.50 ? 742  GLN A OE1 1 
ATOM   3478 N  NE2 . GLN A 1 479 ? -18.858 -43.445 -7.366  1.00 102.23 ? 742  GLN A NE2 1 
ATOM   3479 N  N   . GLY A 1 480 ? -24.059 -42.646 -3.696  1.00 77.04  ? 743  GLY A N   1 
ATOM   3480 C  CA  . GLY A 1 480 ? -25.262 -42.100 -3.032  1.00 76.59  ? 743  GLY A CA  1 
ATOM   3481 C  C   . GLY A 1 480 ? -25.893 -43.035 -2.002  1.00 75.89  ? 743  GLY A C   1 
ATOM   3482 O  O   . GLY A 1 480 ? -25.416 -44.179 -1.829  1.00 75.79  ? 743  GLY A O   1 
ATOM   3483 N  N   . ALA A 1 481 ? -26.952 -42.534 -1.350  1.00 79.59  ? 744  ALA A N   1 
ATOM   3484 C  CA  . ALA A 1 481 ? -27.673 -43.141 -0.207  1.00 75.11  ? 744  ALA A CA  1 
ATOM   3485 C  C   . ALA A 1 481 ? -29.062 -43.609 -0.655  1.00 66.76  ? 744  ALA A C   1 
ATOM   3486 O  O   . ALA A 1 481 ? -29.507 -43.200 -1.742  1.00 63.09  ? 744  ALA A O   1 
ATOM   3487 C  CB  . ALA A 1 481 ? -27.790 -42.136 0.924   1.00 72.60  ? 744  ALA A CB  1 
ATOM   3488 N  N   . GLY A 1 482 ? -29.694 -44.452 0.169   1.00 59.38  ? 745  GLY A N   1 
ATOM   3489 C  CA  . GLY A 1 482 ? -31.106 -44.880 0.069   1.00 52.86  ? 745  GLY A CA  1 
ATOM   3490 C  C   . GLY A 1 482 ? -31.328 -45.838 -1.072  1.00 54.15  ? 745  GLY A C   1 
ATOM   3491 O  O   . GLY A 1 482 ? -32.430 -45.803 -1.637  1.00 57.23  ? 745  GLY A O   1 
ATOM   3492 N  N   . TRP A 1 483 ? -30.327 -46.644 -1.453  1.00 46.29  ? 746  TRP A N   1 
ATOM   3493 C  CA  . TRP A 1 483 ? -30.528 -47.645 -2.533  1.00 44.35  ? 746  TRP A CA  1 
ATOM   3494 C  C   . TRP A 1 483 ? -31.299 -48.840 -1.958  1.00 39.76  ? 746  TRP A C   1 
ATOM   3495 O  O   . TRP A 1 483 ? -30.856 -49.511 -1.034  1.00 41.74  ? 746  TRP A O   1 
ATOM   3496 C  CB  . TRP A 1 483 ? -29.208 -48.090 -3.161  1.00 55.10  ? 746  TRP A CB  1 
ATOM   3497 C  CG  . TRP A 1 483 ? -28.468 -47.043 -3.923  1.00 59.02  ? 746  TRP A CG  1 
ATOM   3498 C  CD1 . TRP A 1 483 ? -27.726 -46.014 -3.407  1.00 76.09  ? 746  TRP A CD1 1 
ATOM   3499 C  CD2 . TRP A 1 483 ? -28.290 -46.987 -5.344  1.00 60.28  ? 746  TRP A CD2 1 
ATOM   3500 N  NE1 . TRP A 1 483 ? -27.140 -45.290 -4.415  1.00 73.37  ? 746  TRP A NE1 1 
ATOM   3501 C  CE2 . TRP A 1 483 ? -27.466 -45.870 -5.616  1.00 68.50  ? 746  TRP A CE2 1 
ATOM   3502 C  CE3 . TRP A 1 483 ? -28.761 -47.752 -6.412  1.00 57.67  ? 746  TRP A CE3 1 
ATOM   3503 C  CZ2 . TRP A 1 483 ? -27.116 -45.504 -6.916  1.00 62.42  ? 746  TRP A CZ2 1 
ATOM   3504 C  CZ3 . TRP A 1 483 ? -28.422 -47.380 -7.697  1.00 60.74  ? 746  TRP A CZ3 1 
ATOM   3505 C  CH2 . TRP A 1 483 ? -27.625 -46.261 -7.944  1.00 58.00  ? 746  TRP A CH2 1 
ATOM   3506 N  N   . SER A 1 484 ? -32.444 -49.123 -2.514  1.00 37.60  ? 747  SER A N   1 
ATOM   3507 C  CA  . SER A 1 484 ? -33.137 -50.395 -2.252  1.00 38.28  ? 747  SER A CA  1 
ATOM   3508 C  C   . SER A 1 484 ? -32.286 -51.520 -2.835  1.00 32.49  ? 747  SER A C   1 
ATOM   3509 O  O   . SER A 1 484 ? -31.444 -51.217 -3.641  1.00 33.41  ? 747  SER A O   1 
ATOM   3510 C  CB  . SER A 1 484 ? -34.484 -50.339 -2.870  1.00 34.09  ? 747  SER A CB  1 
ATOM   3511 O  OG  . SER A 1 484 ? -34.339 -50.230 -4.269  1.00 33.11  ? 747  SER A OG  1 
ATOM   3512 N  N   . LEU A 1 485 ? -32.604 -52.780 -2.522  1.00 34.36  ? 748  LEU A N   1 
ATOM   3513 C  CA  . LEU A 1 485 ? -31.996 -53.963 -3.177  1.00 33.38  ? 748  LEU A CA  1 
ATOM   3514 C  C   . LEU A 1 485 ? -32.285 -53.938 -4.671  1.00 37.41  ? 748  LEU A C   1 
ATOM   3515 O  O   . LEU A 1 485 ? -31.414 -54.326 -5.506  1.00 35.68  ? 748  LEU A O   1 
ATOM   3516 C  CB  . LEU A 1 485 ? -32.533 -55.253 -2.562  1.00 34.07  ? 748  LEU A CB  1 
ATOM   3517 C  CG  . LEU A 1 485 ? -31.883 -56.514 -3.123  1.00 36.06  ? 748  LEU A CG  1 
ATOM   3518 C  CD1 . LEU A 1 485 ? -30.378 -56.298 -3.222  1.00 39.49  ? 748  LEU A CD1 1 
ATOM   3519 C  CD2 . LEU A 1 485 ? -32.200 -57.720 -2.260  1.00 36.63  ? 748  LEU A CD2 1 
ATOM   3520 N  N   . ARG A 1 486 ? -33.490 -53.529 -5.021  1.00 39.40  ? 749  ARG A N   1 
ATOM   3521 C  CA  . ARG A 1 486 ? -33.929 -53.610 -6.421  1.00 35.37  ? 749  ARG A CA  1 
ATOM   3522 C  C   . ARG A 1 486 ? -33.119 -52.614 -7.272  1.00 33.14  ? 749  ARG A C   1 
ATOM   3523 O  O   . ARG A 1 486 ? -32.753 -52.966 -8.420  1.00 32.93  ? 749  ARG A O   1 
ATOM   3524 C  CB  . ARG A 1 486 ? -35.438 -53.350 -6.518  1.00 36.53  ? 749  ARG A CB  1 
ATOM   3525 C  CG  . ARG A 1 486 ? -35.871 -53.090 -7.950  1.00 36.06  ? 749  ARG A CG  1 
ATOM   3526 C  CD  . ARG A 1 486 ? -37.354 -53.226 -8.042  1.00 39.04  ? 749  ARG A CD  1 
ATOM   3527 N  NE  . ARG A 1 486 ? -37.877 -53.056 -9.399  1.00 40.10  ? 749  ARG A NE  1 
ATOM   3528 C  CZ  . ARG A 1 486 ? -39.023 -53.603 -9.799  1.00 38.78  ? 749  ARG A CZ  1 
ATOM   3529 N  NH1 . ARG A 1 486 ? -39.674 -54.392 -8.972  1.00 34.14  ? 749  ARG A NH1 1 
ATOM   3530 N  NH2 . ARG A 1 486 ? -39.471 -53.429 -11.027 1.00 37.57  ? 749  ARG A NH2 1 
ATOM   3531 N  N   . GLU A 1 487 ? -32.901 -51.402 -6.749  0.26 30.67  ? 750  GLU A N   1 
ATOM   3532 C  CA  . GLU A 1 487 ? -32.128 -50.316 -7.413  0.26 30.32  ? 750  GLU A CA  1 
ATOM   3533 C  C   . GLU A 1 487 ? -30.661 -50.754 -7.577  0.26 31.25  ? 750  GLU A C   1 
ATOM   3534 O  O   . GLU A 1 487 ? -30.079 -50.519 -8.663  0.26 30.51  ? 750  GLU A O   1 
ATOM   3535 C  CB  . GLU A 1 487 ? -32.222 -49.020 -6.601  0.26 29.40  ? 750  GLU A CB  1 
ATOM   3536 C  CG  . GLU A 1 487 ? -33.571 -48.325 -6.688  0.26 28.38  ? 750  GLU A CG  1 
ATOM   3537 C  CD  . GLU A 1 487 ? -33.691 -47.086 -5.816  0.26 28.04  ? 750  GLU A CD  1 
ATOM   3538 O  OE1 . GLU A 1 487 ? -33.382 -47.174 -4.613  0.26 27.76  ? 750  GLU A OE1 1 
ATOM   3539 O  OE2 . GLU A 1 487 ? -34.072 -46.027 -6.346  0.26 28.24  ? 750  GLU A OE2 1 
ATOM   3540 N  N   . THR A 1 488 ? -30.094 -51.373 -6.535  1.00 32.04  ? 751  THR A N   1 
ATOM   3541 C  CA  . THR A 1 488 ? -28.705 -51.897 -6.520  1.00 31.23  ? 751  THR A CA  1 
ATOM   3542 C  C   . THR A 1 488 ? -28.560 -52.978 -7.616  1.00 34.78  ? 751  THR A C   1 
ATOM   3543 O  O   . THR A 1 488 ? -27.535 -52.983 -8.346  1.00 36.49  ? 751  THR A O   1 
ATOM   3544 C  CB  . THR A 1 488 ? -28.401 -52.470 -5.133  1.00 31.60  ? 751  THR A CB  1 
ATOM   3545 O  OG1 . THR A 1 488 ? -28.635 -51.441 -4.159  1.00 34.35  ? 751  THR A OG1 1 
ATOM   3546 C  CG2 . THR A 1 488 ? -26.998 -53.025 -5.050  1.00 31.42  ? 751  THR A CG2 1 
ATOM   3547 N  N   . ALA A 1 489 ? -29.563 -53.841 -7.777  1.00 30.34  ? 752  ALA A N   1 
ATOM   3548 C  CA  . ALA A 1 489 ? -29.540 -54.950 -8.748  1.00 27.17  ? 752  ALA A CA  1 
ATOM   3549 C  C   . ALA A 1 489 ? -29.626 -54.373 -10.165 1.00 29.51  ? 752  ALA A C   1 
ATOM   3550 O  O   . ALA A 1 489 ? -28.979 -54.919 -11.056 1.00 29.44  ? 752  ALA A O   1 
ATOM   3551 C  CB  . ALA A 1 489 ? -30.676 -55.899 -8.448  1.00 28.79  ? 752  ALA A CB  1 
ATOM   3552 N  N   . CYS A 1 490 ? -30.439 -53.331 -10.376 1.00 29.49  ? 753  CYS A N   1 
ATOM   3553 C  CA  . CYS A 1 490 ? -30.619 -52.684 -11.706 1.00 32.43  ? 753  CYS A CA  1 
ATOM   3554 C  C   . CYS A 1 490 ? -29.342 -51.928 -12.101 1.00 31.66  ? 753  CYS A C   1 
ATOM   3555 O  O   . CYS A 1 490 ? -29.003 -51.899 -13.274 1.00 29.57  ? 753  CYS A O   1 
ATOM   3556 C  CB  . CYS A 1 490 ? -31.835 -51.755 -11.713 1.00 37.32  ? 753  CYS A CB  1 
ATOM   3557 S  SG  . CYS A 1 490 ? -33.393 -52.683 -11.544 1.00 37.67  ? 753  CYS A SG  1 
ATOM   3558 N  N   . LEU A 1 491 ? -28.630 -51.351 -11.155 1.00 27.98  ? 754  LEU A N   1 
ATOM   3559 C  CA  . LEU A 1 491 ? -27.294 -50.759 -11.458 1.00 32.77  ? 754  LEU A CA  1 
ATOM   3560 C  C   . LEU A 1 491 ? -26.282 -51.868 -11.808 1.00 32.44  ? 754  LEU A C   1 
ATOM   3561 O  O   . LEU A 1 491 ? -25.530 -51.719 -12.765 1.00 32.66  ? 754  LEU A O   1 
ATOM   3562 C  CB  . LEU A 1 491 ? -26.854 -49.929 -10.252 1.00 33.02  ? 754  LEU A CB  1 
ATOM   3563 C  CG  . LEU A 1 491 ? -25.494 -49.262 -10.425 1.00 33.41  ? 754  LEU A CG  1 
ATOM   3564 C  CD1 . LEU A 1 491 ? -25.476 -48.308 -11.619 1.00 32.95  ? 754  LEU A CD1 1 
ATOM   3565 C  CD2 . LEU A 1 491 ? -25.051 -48.571 -9.134  1.00 33.23  ? 754  LEU A CD2 1 
ATOM   3566 N  N   . GLY A 1 492 ? -26.285 -52.974 -11.066 1.00 31.58  ? 755  GLY A N   1 
ATOM   3567 C  CA  . GLY A 1 492 ? -25.419 -54.110 -11.380 1.00 28.75  ? 755  GLY A CA  1 
ATOM   3568 C  C   . GLY A 1 492 ? -25.673 -54.610 -12.784 1.00 29.74  ? 755  GLY A C   1 
ATOM   3569 O  O   . GLY A 1 492 ? -24.730 -54.943 -13.523 1.00 30.38  ? 755  GLY A O   1 
ATOM   3570 N  N   . LYS A 1 493 ? -26.920 -54.586 -13.188 1.00 28.42  ? 756  LYS A N   1 
ATOM   3571 C  CA  . LYS A 1 493 ? -27.387 -55.053 -14.521 1.00 28.42  ? 756  LYS A CA  1 
ATOM   3572 C  C   . LYS A 1 493 ? -26.962 -54.058 -15.594 1.00 25.40  ? 756  LYS A C   1 
ATOM   3573 O  O   . LYS A 1 493 ? -26.769 -54.498 -16.720 1.00 28.48  ? 756  LYS A O   1 
ATOM   3574 C  CB  . LYS A 1 493 ? -28.921 -55.172 -14.516 1.00 30.49  ? 756  LYS A CB  1 
ATOM   3575 C  CG  . LYS A 1 493 ? -29.526 -55.665 -15.828 1.00 34.95  ? 756  LYS A CG  1 
ATOM   3576 C  CD  . LYS A 1 493 ? -31.015 -55.999 -15.729 1.00 33.69  ? 756  LYS A CD  1 
ATOM   3577 C  CE  . LYS A 1 493 ? -31.557 -56.571 -17.021 1.00 35.26  ? 756  LYS A CE  1 
ATOM   3578 N  NZ  . LYS A 1 493 ? -32.888 -57.179 -16.805 1.00 36.86  ? 756  LYS A NZ  1 
ATOM   3579 N  N   . SER A 1 494 ? -26.933 -52.756 -15.319 1.00 24.25  ? 757  SER A N   1 
ATOM   3580 C  CA  . SER A 1 494 ? -26.381 -51.773 -16.288 1.00 30.76  ? 757  SER A CA  1 
ATOM   3581 C  C   . SER A 1 494 ? -24.904 -52.101 -16.559 1.00 30.04  ? 757  SER A C   1 
ATOM   3582 O  O   . SER A 1 494 ? -24.499 -52.038 -17.736 1.00 29.03  ? 757  SER A O   1 
ATOM   3583 C  CB  . SER A 1 494 ? -26.469 -50.340 -15.825 1.00 32.36  ? 757  SER A CB  1 
ATOM   3584 O  OG  . SER A 1 494 ? -27.754 -50.071 -15.324 1.00 44.77  ? 757  SER A OG  1 
ATOM   3585 N  N   . TYR A 1 495 ? -24.113 -52.390 -15.527 1.00 26.76  ? 758  TYR A N   1 
ATOM   3586 C  CA  . TYR A 1 495 ? -22.664 -52.716 -15.744 1.00 30.60  ? 758  TYR A CA  1 
ATOM   3587 C  C   . TYR A 1 495 ? -22.563 -54.006 -16.572 1.00 30.28  ? 758  TYR A C   1 
ATOM   3588 O  O   . TYR A 1 495 ? -21.789 -54.043 -17.507 1.00 30.50  ? 758  TYR A O   1 
ATOM   3589 C  CB  . TYR A 1 495 ? -21.910 -52.804 -14.417 1.00 29.66  ? 758  TYR A CB  1 
ATOM   3590 C  CG  . TYR A 1 495 ? -21.477 -51.470 -13.903 1.00 29.31  ? 758  TYR A CG  1 
ATOM   3591 C  CD1 . TYR A 1 495 ? -20.363 -50.833 -14.456 1.00 32.24  ? 758  TYR A CD1 1 
ATOM   3592 C  CD2 . TYR A 1 495 ? -22.127 -50.854 -12.844 1.00 31.25  ? 758  TYR A CD2 1 
ATOM   3593 C  CE1 . TYR A 1 495 ? -19.982 -49.565 -14.048 1.00 29.46  ? 758  TYR A CE1 1 
ATOM   3594 C  CE2 . TYR A 1 495 ? -21.742 -49.589 -12.403 1.00 31.14  ? 758  TYR A CE2 1 
ATOM   3595 C  CZ  . TYR A 1 495 ? -20.672 -48.946 -13.018 1.00 35.73  ? 758  TYR A CZ  1 
ATOM   3596 O  OH  . TYR A 1 495 ? -20.257 -47.730 -12.578 1.00 34.82  ? 758  TYR A OH  1 
ATOM   3597 N  N   . ALA A 1 496 ? -23.353 -55.033 -16.220 1.00 31.26  ? 759  ALA A N   1 
ATOM   3598 C  CA  . ALA A 1 496 ? -23.329 -56.351 -16.882 1.00 27.09  ? 759  ALA A CA  1 
ATOM   3599 C  C   . ALA A 1 496 ? -23.634 -56.130 -18.360 1.00 28.93  ? 759  ALA A C   1 
ATOM   3600 O  O   . ALA A 1 496 ? -22.902 -56.666 -19.227 1.00 31.62  ? 759  ALA A O   1 
ATOM   3601 C  CB  . ALA A 1 496 ? -24.305 -57.286 -16.226 1.00 28.96  ? 759  ALA A CB  1 
ATOM   3602 N  N   . GLN A 1 497 ? -24.643 -55.312 -18.668 1.00 32.25  ? 760  GLN A N   1 
ATOM   3603 C  CA  . GLN A 1 497 ? -25.058 -55.116 -20.093 1.00 34.59  ? 760  GLN A CA  1 
ATOM   3604 C  C   . GLN A 1 497 ? -23.966 -54.308 -20.813 1.00 31.95  ? 760  GLN A C   1 
ATOM   3605 O  O   . GLN A 1 497 ? -23.646 -54.629 -21.998 1.00 30.05  ? 760  GLN A O   1 
ATOM   3606 C  CB  . GLN A 1 497 ? -26.488 -54.563 -20.171 1.00 36.20  ? 760  GLN A CB  1 
ATOM   3607 C  CG  . GLN A 1 497 ? -27.523 -55.561 -19.648 1.00 36.81  ? 760  GLN A CG  1 
ATOM   3608 C  CD  . GLN A 1 497 ? -28.985 -55.317 -19.989 1.00 36.68  ? 760  GLN A CD  1 
ATOM   3609 O  OE1 . GLN A 1 497 ? -29.753 -56.272 -20.034 1.00 35.09  ? 760  GLN A OE1 1 
ATOM   3610 N  NE2 . GLN A 1 497 ? -29.380 -54.074 -20.225 1.00 32.06  ? 760  GLN A NE2 1 
ATOM   3611 N  N   . MET A 1 498 ? -23.337 -53.360 -20.120 1.00 30.37  ? 761  MET A N   1 
ATOM   3612 C  CA  . MET A 1 498 ? -22.222 -52.590 -20.731 1.00 31.66  ? 761  MET A CA  1 
ATOM   3613 C  C   . MET A 1 498 ? -21.081 -53.552 -21.065 1.00 28.72  ? 761  MET A C   1 
ATOM   3614 O  O   . MET A 1 498 ? -20.495 -53.466 -22.164 1.00 25.20  ? 761  MET A O   1 
ATOM   3615 C  CB  . MET A 1 498 ? -21.680 -51.488 -19.821 1.00 35.64  ? 761  MET A CB  1 
ATOM   3616 C  CG  . MET A 1 498 ? -20.420 -50.834 -20.406 1.00 39.12  ? 761  MET A CG  1 
ATOM   3617 S  SD  . MET A 1 498 ? -19.769 -49.591 -19.320 1.00 45.91  ? 761  MET A SD  1 
ATOM   3618 C  CE  . MET A 1 498 ? -19.176 -50.550 -17.931 1.00 50.32  ? 761  MET A CE  1 
ATOM   3619 N  N   . TRP A 1 499 ? -20.759 -54.440 -20.147 1.00 25.99  ? 762  TRP A N   1 
ATOM   3620 C  CA  . TRP A 1 499 ? -19.662 -55.413 -20.351 1.00 28.03  ? 762  TRP A CA  1 
ATOM   3621 C  C   . TRP A 1 499 ? -19.976 -56.311 -21.560 1.00 31.96  ? 762  TRP A C   1 
ATOM   3622 O  O   . TRP A 1 499 ? -19.053 -56.580 -22.360 1.00 32.82  ? 762  TRP A O   1 
ATOM   3623 C  CB  . TRP A 1 499 ? -19.418 -56.256 -19.095 1.00 27.84  ? 762  TRP A CB  1 
ATOM   3624 C  CG  . TRP A 1 499 ? -18.859 -55.538 -17.915 1.00 26.39  ? 762  TRP A CG  1 
ATOM   3625 C  CD1 . TRP A 1 499 ? -18.335 -54.285 -17.866 1.00 28.78  ? 762  TRP A CD1 1 
ATOM   3626 C  CD2 . TRP A 1 499 ? -18.694 -56.085 -16.602 1.00 27.25  ? 762  TRP A CD2 1 
ATOM   3627 N  NE1 . TRP A 1 499 ? -17.935 -53.987 -16.595 1.00 28.45  ? 762  TRP A NE1 1 
ATOM   3628 C  CE2 . TRP A 1 499 ? -18.111 -55.085 -15.810 1.00 26.81  ? 762  TRP A CE2 1 
ATOM   3629 C  CE3 . TRP A 1 499 ? -18.972 -57.323 -16.035 1.00 28.12  ? 762  TRP A CE3 1 
ATOM   3630 C  CZ2 . TRP A 1 499 ? -17.811 -55.279 -14.473 1.00 29.42  ? 762  TRP A CZ2 1 
ATOM   3631 C  CZ3 . TRP A 1 499 ? -18.706 -57.507 -14.702 1.00 28.64  ? 762  TRP A CZ3 1 
ATOM   3632 C  CH2 . TRP A 1 499 ? -18.139 -56.497 -13.939 1.00 29.17  ? 762  TRP A CH2 1 
ATOM   3633 N  N   A SER A 1 500 ? -21.223 -56.776 -21.694 0.25 30.79  ? 763  SER A N   1 
ATOM   3634 N  N   B SER A 1 500 ? -21.234 -56.762 -21.691 0.25 29.69  ? 763  SER A N   1 
ATOM   3635 C  CA  A SER A 1 500 ? -21.644 -57.664 -22.806 0.25 31.62  ? 763  SER A CA  1 
ATOM   3636 C  CA  B SER A 1 500 ? -21.690 -57.659 -22.785 0.25 29.87  ? 763  SER A CA  1 
ATOM   3637 C  C   A SER A 1 500 ? -21.499 -56.929 -24.147 0.25 31.23  ? 763  SER A C   1 
ATOM   3638 C  C   B SER A 1 500 ? -21.563 -56.942 -24.141 0.25 30.32  ? 763  SER A C   1 
ATOM   3639 O  O   A SER A 1 500 ? -21.170 -57.597 -25.184 0.25 34.43  ? 763  SER A O   1 
ATOM   3640 O  O   B SER A 1 500 ? -21.342 -57.642 -25.190 0.25 33.98  ? 763  SER A O   1 
ATOM   3641 C  CB  A SER A 1 500 ? -23.040 -58.183 -22.584 0.25 34.29  ? 763  SER A CB  1 
ATOM   3642 C  CB  B SER A 1 500 ? -23.100 -58.189 -22.539 0.25 30.91  ? 763  SER A CB  1 
ATOM   3643 O  OG  A SER A 1 500 ? -23.108 -58.839 -21.329 0.25 37.27  ? 763  SER A OG  1 
ATOM   3644 O  OG  B SER A 1 500 ? -24.101 -57.276 -22.980 0.25 30.57  ? 763  SER A OG  1 
ATOM   3645 N  N   . LEU A 1 501 ? -21.707 -55.603 -24.137 1.00 31.64  ? 764  LEU A N   1 
ATOM   3646 C  CA  . LEU A 1 501 ? -21.646 -54.803 -25.389 1.00 34.35  ? 764  LEU A CA  1 
ATOM   3647 C  C   . LEU A 1 501 ? -20.229 -54.339 -25.762 1.00 33.89  ? 764  LEU A C   1 
ATOM   3648 O  O   . LEU A 1 501 ? -19.885 -54.294 -26.973 1.00 36.14  ? 764  LEU A O   1 
ATOM   3649 C  CB  . LEU A 1 501 ? -22.598 -53.622 -25.190 1.00 42.35  ? 764  LEU A CB  1 
ATOM   3650 C  CG  . LEU A 1 501 ? -23.103 -52.976 -26.470 1.00 55.43  ? 764  LEU A CG  1 
ATOM   3651 C  CD1 . LEU A 1 501 ? -23.506 -54.030 -27.504 1.00 61.07  ? 764  LEU A CD1 1 
ATOM   3652 C  CD2 . LEU A 1 501 ? -24.278 -52.047 -26.139 1.00 65.80  ? 764  LEU A CD2 1 
ATOM   3653 N  N   . MET A 1 502 ? -19.429 -53.946 -24.789 1.00 31.31  ? 765  MET A N   1 
ATOM   3654 C  CA  . MET A 1 502 ? -18.131 -53.271 -25.010 1.00 31.22  ? 765  MET A CA  1 
ATOM   3655 C  C   . MET A 1 502 ? -16.952 -54.228 -24.756 1.00 31.67  ? 765  MET A C   1 
ATOM   3656 O  O   . MET A 1 502 ? -15.966 -54.101 -25.462 1.00 30.66  ? 765  MET A O   1 
ATOM   3657 C  CB  . MET A 1 502 ? -18.014 -52.069 -24.066 1.00 33.60  ? 765  MET A CB  1 
ATOM   3658 C  CG  . MET A 1 502 ? -19.019 -50.928 -24.332 1.00 35.25  ? 765  MET A CG  1 
ATOM   3659 S  SD  . MET A 1 502 ? -18.926 -50.238 -26.023 1.00 40.02  ? 765  MET A SD  1 
ATOM   3660 C  CE  . MET A 1 502 ? -20.114 -51.196 -26.931 1.00 48.86  ? 765  MET A CE  1 
ATOM   3661 N  N   . TYR A 1 503 ? -17.051 -55.111 -23.762 1.00 29.09  ? 766  TYR A N   1 
ATOM   3662 C  CA  . TYR A 1 503 ? -15.946 -55.925 -23.213 1.00 30.20  ? 766  TYR A CA  1 
ATOM   3663 C  C   . TYR A 1 503 ? -16.262 -57.426 -23.313 1.00 30.15  ? 766  TYR A C   1 
ATOM   3664 O  O   . TYR A 1 503 ? -15.782 -58.208 -22.488 1.00 30.62  ? 766  TYR A O   1 
ATOM   3665 C  CB  . TYR A 1 503 ? -15.738 -55.491 -21.766 1.00 30.51  ? 766  TYR A CB  1 
ATOM   3666 C  CG  . TYR A 1 503 ? -15.486 -54.005 -21.600 1.00 30.75  ? 766  TYR A CG  1 
ATOM   3667 C  CD1 . TYR A 1 503 ? -14.497 -53.319 -22.284 1.00 30.79  ? 766  TYR A CD1 1 
ATOM   3668 C  CD2 . TYR A 1 503 ? -16.266 -53.262 -20.737 1.00 33.19  ? 766  TYR A CD2 1 
ATOM   3669 C  CE1 . TYR A 1 503 ? -14.303 -51.950 -22.113 1.00 30.48  ? 766  TYR A CE1 1 
ATOM   3670 C  CE2 . TYR A 1 503 ? -16.112 -51.895 -20.582 1.00 30.93  ? 766  TYR A CE2 1 
ATOM   3671 C  CZ  . TYR A 1 503 ? -15.118 -51.236 -21.258 1.00 31.58  ? 766  TYR A CZ  1 
ATOM   3672 O  OH  . TYR A 1 503 ? -15.000 -49.915 -20.982 1.00 29.81  ? 766  TYR A OH  1 
ATOM   3673 N  N   . PHE A 1 504 ? -17.029 -57.815 -24.334 1.00 31.36  ? 767  PHE A N   1 
ATOM   3674 C  CA  . PHE A 1 504 ? -17.516 -59.203 -24.580 1.00 32.56  ? 767  PHE A CA  1 
ATOM   3675 C  C   . PHE A 1 504 ? -16.307 -60.104 -24.808 1.00 30.05  ? 767  PHE A C   1 
ATOM   3676 O  O   . PHE A 1 504 ? -16.395 -61.340 -24.535 1.00 32.63  ? 767  PHE A O   1 
ATOM   3677 C  CB  . PHE A 1 504 ? -18.451 -59.280 -25.799 1.00 27.31  ? 767  PHE A CB  1 
ATOM   3678 C  CG  . PHE A 1 504 ? -17.942 -58.556 -27.026 1.00 25.28  ? 767  PHE A CG  1 
ATOM   3679 C  CD1 . PHE A 1 504 ? -17.083 -59.172 -27.907 1.00 26.87  ? 767  PHE A CD1 1 
ATOM   3680 C  CD2 . PHE A 1 504 ? -18.236 -57.226 -27.228 1.00 26.27  ? 767  PHE A CD2 1 
ATOM   3681 C  CE1 . PHE A 1 504 ? -16.544 -58.490 -28.987 1.00 25.22  ? 767  PHE A CE1 1 
ATOM   3682 C  CE2 . PHE A 1 504 ? -17.718 -56.545 -28.316 1.00 28.23  ? 767  PHE A CE2 1 
ATOM   3683 C  CZ  . PHE A 1 504 ? -16.855 -57.168 -29.183 1.00 29.29  ? 767  PHE A CZ  1 
ATOM   3684 N  N   . HIS A 1 505 ? -15.216 -59.490 -25.282 1.00 31.47  ? 768  HIS A N   1 
ATOM   3685 C  CA  . HIS A 1 505 ? -13.937 -60.161 -25.693 1.00 30.45  ? 768  HIS A CA  1 
ATOM   3686 C  C   . HIS A 1 505 ? -13.064 -60.555 -24.486 1.00 27.73  ? 768  HIS A C   1 
ATOM   3687 O  O   . HIS A 1 505 ? -12.039 -61.227 -24.682 1.00 32.50  ? 768  HIS A O   1 
ATOM   3688 C  CB  . HIS A 1 505 ? -13.180 -59.272 -26.672 1.00 27.77  ? 768  HIS A CB  1 
ATOM   3689 C  CG  . HIS A 1 505 ? -13.023 -57.879 -26.197 1.00 29.67  ? 768  HIS A CG  1 
ATOM   3690 N  ND1 . HIS A 1 505 ? -11.948 -57.483 -25.418 1.00 30.51  ? 768  HIS A ND1 1 
ATOM   3691 C  CD2 . HIS A 1 505 ? -13.822 -56.788 -26.366 1.00 34.74  ? 768  HIS A CD2 1 
ATOM   3692 C  CE1 . HIS A 1 505 ? -12.102 -56.212 -25.109 1.00 36.81  ? 768  HIS A CE1 1 
ATOM   3693 N  NE2 . HIS A 1 505 ? -13.243 -55.741 -25.701 1.00 30.66  ? 768  HIS A NE2 1 
ATOM   3694 N  N   . ARG A 1 506 ? -13.403 -60.099 -23.282 1.00 27.19  ? 769  ARG A N   1 
ATOM   3695 C  CA  . ARG A 1 506 ? -12.695 -60.461 -22.041 1.00 25.67  ? 769  ARG A CA  1 
ATOM   3696 C  C   . ARG A 1 506 ? -13.472 -61.637 -21.430 1.00 27.91  ? 769  ARG A C   1 
ATOM   3697 O  O   . ARG A 1 506 ? -14.655 -61.453 -21.091 1.00 29.72  ? 769  ARG A O   1 
ATOM   3698 C  CB  . ARG A 1 506 ? -12.662 -59.249 -21.099 1.00 27.18  ? 769  ARG A CB  1 
ATOM   3699 C  CG  . ARG A 1 506 ? -12.194 -57.939 -21.727 1.00 26.03  ? 769  ARG A CG  1 
ATOM   3700 C  CD  . ARG A 1 506 ? -10.845 -58.030 -22.439 1.00 27.86  ? 769  ARG A CD  1 
ATOM   3701 N  NE  . ARG A 1 506 ? -9.909  -58.559 -21.466 1.00 27.81  ? 769  ARG A NE  1 
ATOM   3702 C  CZ  . ARG A 1 506 ? -9.425  -57.898 -20.428 1.00 26.77  ? 769  ARG A CZ  1 
ATOM   3703 N  NH1 . ARG A 1 506 ? -8.780  -58.588 -19.504 1.00 27.05  ? 769  ARG A NH1 1 
ATOM   3704 N  NH2 . ARG A 1 506 ? -9.540  -56.581 -20.306 1.00 26.43  ? 769  ARG A NH2 1 
ATOM   3705 N  N   . ARG A 1 507 ? -12.823 -62.800 -21.282 0.50 27.52  ? 770  ARG A N   1 
ATOM   3706 C  CA  . ARG A 1 507 ? -13.450 -64.056 -20.797 0.50 27.56  ? 770  ARG A CA  1 
ATOM   3707 C  C   . ARG A 1 507 ? -14.151 -63.810 -19.460 0.50 27.17  ? 770  ARG A C   1 
ATOM   3708 O  O   . ARG A 1 507 ? -15.291 -64.269 -19.314 0.50 27.70  ? 770  ARG A O   1 
ATOM   3709 C  CB  . ARG A 1 507 ? -12.412 -65.169 -20.655 0.50 29.43  ? 770  ARG A CB  1 
ATOM   3710 C  CG  . ARG A 1 507 ? -11.985 -65.775 -21.984 0.50 30.92  ? 770  ARG A CG  1 
ATOM   3711 C  CD  . ARG A 1 507 ? -10.618 -66.443 -21.956 0.50 31.48  ? 770  ARG A CD  1 
ATOM   3712 N  NE  . ARG A 1 507 ? -10.320 -66.937 -23.288 0.50 30.32  ? 770  ARG A NE  1 
ATOM   3713 C  CZ  . ARG A 1 507 ? -9.679  -66.235 -24.205 0.50 32.34  ? 770  ARG A CZ  1 
ATOM   3714 N  NH1 . ARG A 1 507 ? -9.242  -65.021 -23.918 0.50 31.91  ? 770  ARG A NH1 1 
ATOM   3715 N  NH2 . ARG A 1 507 ? -9.474  -66.745 -25.404 0.50 33.10  ? 770  ARG A NH2 1 
ATOM   3716 N  N   . ASP A 1 508 ? -13.507 -63.119 -18.520 1.00 26.95  ? 771  ASP A N   1 
ATOM   3717 C  CA  . ASP A 1 508 ? -14.081 -62.988 -17.151 1.00 29.42  ? 771  ASP A CA  1 
ATOM   3718 C  C   . ASP A 1 508 ? -15.325 -62.067 -17.177 1.00 30.41  ? 771  ASP A C   1 
ATOM   3719 O  O   . ASP A 1 508 ? -16.184 -62.249 -16.336 1.00 28.66  ? 771  ASP A O   1 
ATOM   3720 C  CB  . ASP A 1 508 ? -13.089 -62.477 -16.127 1.00 27.01  ? 771  ASP A CB  1 
ATOM   3721 C  CG  . ASP A 1 508 ? -11.865 -63.344 -15.925 1.00 28.15  ? 771  ASP A CG  1 
ATOM   3722 O  OD1 . ASP A 1 508 ? -11.879 -64.514 -16.306 1.00 25.98  ? 771  ASP A OD1 1 
ATOM   3723 O  OD2 . ASP A 1 508 ? -10.915 -62.812 -15.365 1.00 28.13  ? 771  ASP A OD2 1 
ATOM   3724 N  N   . LEU A 1 509 ? -15.379 -61.099 -18.090 1.00 32.00  ? 772  LEU A N   1 
ATOM   3725 C  CA  . LEU A 1 509 ? -16.438 -60.061 -18.097 1.00 31.62  ? 772  LEU A CA  1 
ATOM   3726 C  C   . LEU A 1 509 ? -17.660 -60.641 -18.819 1.00 31.77  ? 772  LEU A C   1 
ATOM   3727 O  O   . LEU A 1 509 ? -18.731 -60.375 -18.369 1.00 30.17  ? 772  LEU A O   1 
ATOM   3728 C  CB  . LEU A 1 509 ? -15.903 -58.770 -18.743 1.00 29.66  ? 772  LEU A CB  1 
ATOM   3729 C  CG  . LEU A 1 509 ? -14.859 -58.000 -17.934 1.00 30.65  ? 772  LEU A CG  1 
ATOM   3730 C  CD1 . LEU A 1 509 ? -14.688 -56.582 -18.475 1.00 29.20  ? 772  LEU A CD1 1 
ATOM   3731 C  CD2 . LEU A 1 509 ? -15.152 -58.008 -16.438 1.00 31.11  ? 772  LEU A CD2 1 
ATOM   3732 N  N   . ARG A 1 510 ? -17.489 -61.462 -19.865 1.00 34.11  ? 773  ARG A N   1 
ATOM   3733 C  CA  . ARG A 1 510 ? -18.630 -62.147 -20.500 1.00 29.93  ? 773  ARG A CA  1 
ATOM   3734 C  C   . ARG A 1 510 ? -19.292 -63.074 -19.477 1.00 32.03  ? 773  ARG A C   1 
ATOM   3735 O  O   . ARG A 1 510 ? -20.533 -63.111 -19.393 1.00 30.13  ? 773  ARG A O   1 
ATOM   3736 C  CB  . ARG A 1 510 ? -18.256 -62.893 -21.777 1.00 32.22  ? 773  ARG A CB  1 
ATOM   3737 C  CG  . ARG A 1 510 ? -19.481 -63.212 -22.640 1.00 33.82  ? 773  ARG A CG  1 
ATOM   3738 C  CD  . ARG A 1 510 ? -19.194 -64.074 -23.852 1.00 30.07  ? 773  ARG A CD  1 
ATOM   3739 N  NE  . ARG A 1 510 ? -18.296 -63.467 -24.813 1.00 31.00  ? 773  ARG A NE  1 
ATOM   3740 C  CZ  . ARG A 1 510 ? -18.153 -63.859 -26.085 1.00 33.20  ? 773  ARG A CZ  1 
ATOM   3741 N  NH1 . ARG A 1 510 ? -18.931 -64.799 -26.588 1.00 34.82  ? 773  ARG A NH1 1 
ATOM   3742 N  NH2 . ARG A 1 510 ? -17.274 -63.270 -26.875 1.00 30.68  ? 773  ARG A NH2 1 
ATOM   3743 N  N   . LEU A 1 511 ? -18.491 -63.800 -18.694 0.50 31.46  ? 774  LEU A N   1 
ATOM   3744 C  CA  . LEU A 1 511 ? -19.024 -64.802 -17.735 0.50 31.91  ? 774  LEU A CA  1 
ATOM   3745 C  C   . LEU A 1 511 ? -19.719 -64.071 -16.579 0.50 31.91  ? 774  LEU A C   1 
ATOM   3746 O  O   . LEU A 1 511 ? -20.863 -64.447 -16.253 0.50 32.07  ? 774  LEU A O   1 
ATOM   3747 C  CB  . LEU A 1 511 ? -17.897 -65.713 -17.247 0.50 31.72  ? 774  LEU A CB  1 
ATOM   3748 C  CG  . LEU A 1 511 ? -18.351 -67.001 -16.558 0.50 33.71  ? 774  LEU A CG  1 
ATOM   3749 C  CD1 . LEU A 1 511 ? -17.229 -68.024 -16.525 0.50 34.66  ? 774  LEU A CD1 1 
ATOM   3750 C  CD2 . LEU A 1 511 ? -18.846 -66.718 -15.147 0.50 34.24  ? 774  LEU A CD2 1 
ATOM   3751 N  N   . ALA A 1 512 ? -19.082 -63.046 -16.010 1.00 30.83  ? 775  ALA A N   1 
ATOM   3752 C  CA  . ALA A 1 512 ? -19.669 -62.292 -14.879 1.00 30.04  ? 775  ALA A CA  1 
ATOM   3753 C  C   . ALA A 1 512 ? -20.952 -61.569 -15.366 1.00 30.11  ? 775  ALA A C   1 
ATOM   3754 O  O   . ALA A 1 512 ? -21.902 -61.505 -14.597 1.00 28.61  ? 775  ALA A O   1 
ATOM   3755 C  CB  . ALA A 1 512 ? -18.672 -61.335 -14.293 1.00 27.86  ? 775  ALA A CB  1 
ATOM   3756 N  N   . ALA A 1 513 ? -20.974 -61.060 -16.603 1.00 28.61  ? 776  ALA A N   1 
ATOM   3757 C  CA  . ALA A 1 513 ? -22.092 -60.264 -17.139 1.00 30.69  ? 776  ALA A CA  1 
ATOM   3758 C  C   . ALA A 1 513 ? -23.294 -61.216 -17.286 1.00 35.63  ? 776  ALA A C   1 
ATOM   3759 O  O   . ALA A 1 513 ? -24.435 -60.831 -16.866 1.00 32.69  ? 776  ALA A O   1 
ATOM   3760 C  CB  . ALA A 1 513 ? -21.732 -59.604 -18.457 1.00 27.26  ? 776  ALA A CB  1 
ATOM   3761 N  N   . ASN A 1 514 ? -23.047 -62.417 -17.832 1.00 32.88  ? 777  ASN A N   1 
ATOM   3762 C  CA  . ASN A 1 514 ? -24.073 -63.489 -17.946 1.00 33.27  ? 777  ASN A CA  1 
ATOM   3763 C  C   . ASN A 1 514 ? -24.571 -63.879 -16.554 1.00 31.71  ? 777  ASN A C   1 
ATOM   3764 O  O   . ASN A 1 514 ? -25.796 -64.022 -16.368 1.00 37.06  ? 777  ASN A O   1 
ATOM   3765 C  CB  . ASN A 1 514 ? -23.545 -64.702 -18.717 1.00 33.76  ? 777  ASN A CB  1 
ATOM   3766 C  CG  . ASN A 1 514 ? -23.505 -64.422 -20.201 1.00 33.71  ? 777  ASN A CG  1 
ATOM   3767 O  OD1 . ASN A 1 514 ? -24.319 -63.671 -20.717 1.00 35.95  ? 777  ASN A OD1 1 
ATOM   3768 N  ND2 . ASN A 1 514 ? -22.568 -65.017 -20.912 1.00 39.33  ? 777  ASN A ND2 1 
ATOM   3769 N  N   . ALA A 1 515 ? -23.689 -64.030 -15.584 1.00 29.58  ? 778  ALA A N   1 
ATOM   3770 C  CA  . ALA A 1 515 ? -24.070 -64.389 -14.197 1.00 29.50  ? 778  ALA A CA  1 
ATOM   3771 C  C   . ALA A 1 515 ? -24.937 -63.269 -13.616 1.00 31.40  ? 778  ALA A C   1 
ATOM   3772 O  O   . ALA A 1 515 ? -25.956 -63.548 -13.002 1.00 28.82  ? 778  ALA A O   1 
ATOM   3773 C  CB  . ALA A 1 515 ? -22.852 -64.651 -13.351 1.00 30.43  ? 778  ALA A CB  1 
ATOM   3774 N  N   . ILE A 1 516 ? -24.541 -62.011 -13.765 1.00 33.25  ? 779  ILE A N   1 
ATOM   3775 C  CA  . ILE A 1 516 ? -25.334 -60.904 -13.171 1.00 31.46  ? 779  ILE A CA  1 
ATOM   3776 C  C   . ILE A 1 516 ? -26.722 -60.868 -13.862 1.00 33.20  ? 779  ILE A C   1 
ATOM   3777 O  O   . ILE A 1 516 ? -27.697 -60.726 -13.148 1.00 29.15  ? 779  ILE A O   1 
ATOM   3778 C  CB  . ILE A 1 516 ? -24.611 -59.553 -13.250 1.00 30.67  ? 779  ILE A CB  1 
ATOM   3779 C  CG1 . ILE A 1 516 ? -23.369 -59.550 -12.363 1.00 32.75  ? 779  ILE A CG1 1 
ATOM   3780 C  CG2 . ILE A 1 516 ? -25.579 -58.419 -12.898 1.00 31.49  ? 779  ILE A CG2 1 
ATOM   3781 C  CD1 . ILE A 1 516 ? -22.386 -58.466 -12.708 1.00 33.15  ? 779  ILE A CD1 1 
ATOM   3782 N  N   . CYS A 1 517 ? -26.814 -60.967 -15.189 1.00 31.27  ? 780  CYS A N   1 
ATOM   3783 C  CA  . CYS A 1 517 ? -28.097 -60.931 -15.928 1.00 35.80  ? 780  CYS A CA  1 
ATOM   3784 C  C   . CYS A 1 517 ? -28.973 -62.150 -15.591 1.00 37.10  ? 780  CYS A C   1 
ATOM   3785 O  O   . CYS A 1 517 ? -30.202 -62.013 -15.665 1.00 33.09  ? 780  CYS A O   1 
ATOM   3786 C  CB  . CYS A 1 517 ? -27.842 -60.789 -17.414 1.00 33.04  ? 780  CYS A CB  1 
ATOM   3787 S  SG  . CYS A 1 517 ? -27.246 -59.116 -17.728 1.00 35.68  ? 780  CYS A SG  1 
ATOM   3788 N  N   . SER A 1 518 ? -28.383 -63.251 -15.143 1.00 32.62  ? 781  SER A N   1 
ATOM   3789 C  CA  . SER A 1 518 ? -29.103 -64.468 -14.697 1.00 34.05  ? 781  SER A CA  1 
ATOM   3790 C  C   . SER A 1 518 ? -29.645 -64.238 -13.294 1.00 34.68  ? 781  SER A C   1 
ATOM   3791 O  O   . SER A 1 518 ? -30.721 -64.826 -12.954 1.00 34.15  ? 781  SER A O   1 
ATOM   3792 C  CB  . SER A 1 518 ? -28.223 -65.727 -14.732 1.00 31.81  ? 781  SER A CB  1 
ATOM   3793 O  OG  . SER A 1 518 ? -27.944 -66.078 -16.079 1.00 38.21  ? 781  SER A OG  1 
ATOM   3794 N  N   . ALA A 1 519 ? -28.935 -63.436 -12.503 1.00 35.02  ? 782  ALA A N   1 
ATOM   3795 C  CA  . ALA A 1 519 ? -29.225 -63.256 -11.056 1.00 35.86  ? 782  ALA A CA  1 
ATOM   3796 C  C   . ALA A 1 519 ? -30.235 -62.115 -10.804 1.00 31.19  ? 782  ALA A C   1 
ATOM   3797 O  O   . ALA A 1 519 ? -30.722 -62.015 -9.703  1.00 30.60  ? 782  ALA A O   1 
ATOM   3798 C  CB  . ALA A 1 519 ? -27.939 -63.062 -10.279 1.00 36.09  ? 782  ALA A CB  1 
ATOM   3799 N  N   . VAL A 1 520 ? -30.418 -61.208 -11.746 1.00 31.42  ? 783  VAL A N   1 
ATOM   3800 C  CA  . VAL A 1 520 ? -31.352 -60.062 -11.646 1.00 33.26  ? 783  VAL A CA  1 
ATOM   3801 C  C   . VAL A 1 520 ? -32.604 -60.422 -12.464 1.00 34.33  ? 783  VAL A C   1 
ATOM   3802 O  O   . VAL A 1 520 ? -32.501 -60.911 -13.589 1.00 33.96  ? 783  VAL A O   1 
ATOM   3803 C  CB  . VAL A 1 520 ? -30.715 -58.754 -12.136 1.00 34.58  ? 783  VAL A CB  1 
ATOM   3804 C  CG1 . VAL A 1 520 ? -31.685 -57.575 -12.004 1.00 31.49  ? 783  VAL A CG1 1 
ATOM   3805 C  CG2 . VAL A 1 520 ? -29.408 -58.423 -11.405 1.00 32.93  ? 783  VAL A CG2 1 
ATOM   3806 N  N   . PRO A 1 521 ? -33.824 -60.156 -11.935 1.00 33.81  ? 784  PRO A N   1 
ATOM   3807 C  CA  . PRO A 1 521 ? -35.061 -60.504 -12.646 1.00 32.46  ? 784  PRO A CA  1 
ATOM   3808 C  C   . PRO A 1 521 ? -35.012 -59.987 -14.082 1.00 34.50  ? 784  PRO A C   1 
ATOM   3809 O  O   . PRO A 1 521 ? -34.703 -58.813 -14.287 1.00 35.75  ? 784  PRO A O   1 
ATOM   3810 C  CB  . PRO A 1 521 ? -36.142 -59.860 -11.772 1.00 33.22  ? 784  PRO A CB  1 
ATOM   3811 C  CG  . PRO A 1 521 ? -35.564 -59.987 -10.363 1.00 37.53  ? 784  PRO A CG  1 
ATOM   3812 C  CD  . PRO A 1 521 ? -34.088 -59.628 -10.580 1.00 33.76  ? 784  PRO A CD  1 
ATOM   3813 N  N   A SER A 1 522 ? -35.315 -60.878 -15.034 0.25 35.58  ? 785  SER A N   1 
ATOM   3814 N  N   B SER A 1 522 ? -35.327 -60.869 -15.040 0.25 34.62  ? 785  SER A N   1 
ATOM   3815 C  CA  A SER A 1 522 ? -35.185 -60.692 -16.503 0.25 36.72  ? 785  SER A CA  1 
ATOM   3816 C  CA  B SER A 1 522 ? -35.153 -60.675 -16.504 0.25 35.12  ? 785  SER A CA  1 
ATOM   3817 C  C   A SER A 1 522 ? -35.771 -59.349 -16.945 0.25 37.82  ? 785  SER A C   1 
ATOM   3818 C  C   B SER A 1 522 ? -35.774 -59.350 -16.958 0.25 36.92  ? 785  SER A C   1 
ATOM   3819 O  O   A SER A 1 522 ? -35.140 -58.684 -17.781 0.25 37.21  ? 785  SER A O   1 
ATOM   3820 O  O   B SER A 1 522 ? -35.169 -58.692 -17.819 0.25 36.40  ? 785  SER A O   1 
ATOM   3821 C  CB  A SER A 1 522 ? -35.848 -61.836 -17.235 0.25 41.09  ? 785  SER A CB  1 
ATOM   3822 C  CB  B SER A 1 522 ? -35.736 -61.839 -17.281 0.25 38.16  ? 785  SER A CB  1 
ATOM   3823 O  OG  A SER A 1 522 ? -37.183 -62.026 -16.777 0.25 44.06  ? 785  SER A OG  1 
ATOM   3824 O  OG  B SER A 1 522 ? -35.559 -63.069 -16.588 0.25 38.92  ? 785  SER A OG  1 
ATOM   3825 N  N   . HIS A 1 523 ? -36.940 -58.977 -16.412 1.00 37.59  ? 786  HIS A N   1 
ATOM   3826 C  CA  . HIS A 1 523 ? -37.684 -57.750 -16.836 1.00 37.68  ? 786  HIS A CA  1 
ATOM   3827 C  C   . HIS A 1 523 ? -37.296 -56.488 -16.048 1.00 37.31  ? 786  HIS A C   1 
ATOM   3828 O  O   . HIS A 1 523 ? -37.771 -55.418 -16.480 1.00 39.77  ? 786  HIS A O   1 
ATOM   3829 C  CB  . HIS A 1 523 ? -39.203 -58.030 -16.783 1.00 40.35  ? 786  HIS A CB  1 
ATOM   3830 C  CG  . HIS A 1 523 ? -39.618 -59.155 -17.681 1.00 43.60  ? 786  HIS A CG  1 
ATOM   3831 N  ND1 . HIS A 1 523 ? -39.673 -59.015 -19.066 1.00 42.53  ? 786  HIS A ND1 1 
ATOM   3832 C  CD2 . HIS A 1 523 ? -39.929 -60.449 -17.412 1.00 47.33  ? 786  HIS A CD2 1 
ATOM   3833 C  CE1 . HIS A 1 523 ? -40.024 -60.167 -19.606 1.00 47.51  ? 786  HIS A CE1 1 
ATOM   3834 N  NE2 . HIS A 1 523 ? -40.193 -61.077 -18.611 1.00 47.13  ? 786  HIS A NE2 1 
ATOM   3835 N  N   . TRP A 1 524 ? -36.464 -56.544 -14.990 1.00 34.74  ? 787  TRP A N   1 
ATOM   3836 C  CA  . TRP A 1 524 ? -36.079 -55.315 -14.228 1.00 35.79  ? 787  TRP A CA  1 
ATOM   3837 C  C   . TRP A 1 524 ? -35.207 -54.407 -15.093 1.00 37.34  ? 787  TRP A C   1 
ATOM   3838 O  O   . TRP A 1 524 ? -34.384 -54.913 -15.867 1.00 36.42  ? 787  TRP A O   1 
ATOM   3839 C  CB  . TRP A 1 524 ? -35.428 -55.648 -12.891 1.00 35.28  ? 787  TRP A CB  1 
ATOM   3840 C  CG  . TRP A 1 524 ? -36.420 -56.126 -11.877 1.00 39.43  ? 787  TRP A CG  1 
ATOM   3841 C  CD1 . TRP A 1 524 ? -37.737 -56.432 -12.100 1.00 41.31  ? 787  TRP A CD1 1 
ATOM   3842 C  CD2 . TRP A 1 524 ? -36.187 -56.402 -10.482 1.00 38.58  ? 787  TRP A CD2 1 
ATOM   3843 N  NE1 . TRP A 1 524 ? -38.332 -56.865 -10.944 1.00 38.23  ? 787  TRP A NE1 1 
ATOM   3844 C  CE2 . TRP A 1 524 ? -37.419 -56.823 -9.928  1.00 37.56  ? 787  TRP A CE2 1 
ATOM   3845 C  CE3 . TRP A 1 524 ? -35.076 -56.302 -9.646  1.00 38.66  ? 787  TRP A CE3 1 
ATOM   3846 C  CZ2 . TRP A 1 524 ? -37.562 -57.158 -8.586  1.00 35.12  ? 787  TRP A CZ2 1 
ATOM   3847 C  CZ3 . TRP A 1 524 ? -35.217 -56.660 -8.322  1.00 43.59  ? 787  TRP A CZ3 1 
ATOM   3848 C  CH2 . TRP A 1 524 ? -36.447 -57.063 -7.798  1.00 38.75  ? 787  TRP A CH2 1 
ATOM   3849 N  N   . VAL A 1 525 ? -35.468 -53.108 -15.060 1.00 37.65  ? 788  VAL A N   1 
ATOM   3850 C  CA  . VAL A 1 525 ? -34.859 -52.180 -16.047 1.00 43.53  ? 788  VAL A CA  1 
ATOM   3851 C  C   . VAL A 1 525 ? -33.502 -51.729 -15.481 1.00 42.60  ? 788  VAL A C   1 
ATOM   3852 O  O   . VAL A 1 525 ? -33.380 -51.317 -14.327 1.00 38.35  ? 788  VAL A O   1 
ATOM   3853 C  CB  . VAL A 1 525 ? -35.798 -50.996 -16.392 1.00 47.50  ? 788  VAL A CB  1 
ATOM   3854 C  CG1 . VAL A 1 525 ? -35.208 -50.098 -17.472 1.00 48.18  ? 788  VAL A CG1 1 
ATOM   3855 C  CG2 . VAL A 1 525 ? -37.199 -51.448 -16.816 1.00 47.08  ? 788  VAL A CG2 1 
ATOM   3856 N  N   . PRO A 1 526 ? -32.432 -51.726 -16.298 1.00 42.63  ? 789  PRO A N   1 
ATOM   3857 C  CA  . PRO A 1 526 ? -31.166 -51.130 -15.871 1.00 45.35  ? 789  PRO A CA  1 
ATOM   3858 C  C   . PRO A 1 526 ? -31.279 -49.627 -15.579 1.00 48.52  ? 789  PRO A C   1 
ATOM   3859 O  O   . PRO A 1 526 ? -31.877 -48.924 -16.385 1.00 46.57  ? 789  PRO A O   1 
ATOM   3860 C  CB  . PRO A 1 526 ? -30.228 -51.323 -17.063 1.00 41.74  ? 789  PRO A CB  1 
ATOM   3861 C  CG  . PRO A 1 526 ? -30.936 -52.277 -18.020 1.00 44.21  ? 789  PRO A CG  1 
ATOM   3862 C  CD  . PRO A 1 526 ? -32.405 -52.233 -17.679 1.00 43.36  ? 789  PRO A CD  1 
ATOM   3863 N  N   . THR A 1 527 ? -30.717 -49.189 -14.443 0.26 50.46  ? 790  THR A N   1 
ATOM   3864 C  CA  . THR A 1 527 ? -30.694 -47.779 -13.959 0.26 53.63  ? 790  THR A CA  1 
ATOM   3865 C  C   . THR A 1 527 ? -29.254 -47.288 -13.791 0.26 54.93  ? 790  THR A C   1 
ATOM   3866 O  O   . THR A 1 527 ? -28.333 -48.122 -13.810 0.26 54.41  ? 790  THR A O   1 
ATOM   3867 C  CB  . THR A 1 527 ? -31.398 -47.615 -12.607 0.26 55.12  ? 790  THR A CB  1 
ATOM   3868 O  OG1 . THR A 1 527 ? -30.787 -48.488 -11.655 0.26 56.46  ? 790  THR A OG1 1 
ATOM   3869 C  CG2 . THR A 1 527 ? -32.882 -47.890 -12.685 0.26 55.82  ? 790  THR A CG2 1 
ATOM   3870 N  N   . SER A 1 528 ? -29.098 -45.975 -13.600 0.26 59.04  ? 791  SER A N   1 
ATOM   3871 C  CA  . SER A 1 528 ? -27.810 -45.265 -13.390 0.26 62.40  ? 791  SER A CA  1 
ATOM   3872 C  C   . SER A 1 528 ? -28.094 -43.810 -13.001 0.26 66.10  ? 791  SER A C   1 
ATOM   3873 O  O   . SER A 1 528 ? -28.607 -43.068 -13.865 0.26 70.41  ? 791  SER A O   1 
ATOM   3874 C  CB  . SER A 1 528 ? -26.949 -45.344 -14.624 0.26 62.54  ? 791  SER A CB  1 
ATOM   3875 O  OG  . SER A 1 528 ? -26.008 -44.283 -14.651 0.26 64.97  ? 791  SER A OG  1 
ATOM   3876 N  N   . ARG A 1 529 ? -27.779 -43.426 -11.757 0.26 67.87  ? 792  ARG A N   1 
ATOM   3877 C  CA  . ARG A 1 529 ? -27.956 -42.041 -11.233 0.26 66.51  ? 792  ARG A CA  1 
ATOM   3878 C  C   . ARG A 1 529 ? -26.955 -41.108 -11.926 0.26 66.49  ? 792  ARG A C   1 
ATOM   3879 O  O   . ARG A 1 529 ? -27.404 -40.050 -12.411 0.26 65.35  ? 792  ARG A O   1 
ATOM   3880 C  CB  . ARG A 1 529 ? -27.765 -41.994 -9.714  0.26 66.40  ? 792  ARG A CB  1 
ATOM   3881 C  CG  . ARG A 1 529 ? -28.805 -42.779 -8.926  0.26 67.44  ? 792  ARG A CG  1 
ATOM   3882 C  CD  . ARG A 1 529 ? -28.810 -42.423 -7.449  0.26 67.80  ? 792  ARG A CD  1 
ATOM   3883 N  NE  . ARG A 1 529 ? -29.483 -43.427 -6.627  0.26 68.12  ? 792  ARG A NE  1 
ATOM   3884 C  CZ  . ARG A 1 529 ? -29.738 -43.308 -5.324  0.26 66.44  ? 792  ARG A CZ  1 
ATOM   3885 N  NH1 . ARG A 1 529 ? -29.387 -42.215 -4.667  0.26 67.03  ? 792  ARG A NH1 1 
ATOM   3886 N  NH2 . ARG A 1 529 ? -30.351 -44.288 -4.681  0.26 64.40  ? 792  ARG A NH2 1 
ATOM   3887 N  N   . ALA A 1 536 ? -20.878 -41.094 -23.900 1.00 110.66 ? 799  ALA A N   1 
ATOM   3888 C  CA  . ALA A 1 536 ? -21.426 -40.645 -25.203 1.00 116.02 ? 799  ALA A CA  1 
ATOM   3889 C  C   . ALA A 1 536 ? -22.739 -41.395 -25.511 1.00 120.19 ? 799  ALA A C   1 
ATOM   3890 O  O   . ALA A 1 536 ? -23.825 -40.783 -25.390 1.00 127.83 ? 799  ALA A O   1 
ATOM   3891 C  CB  . ALA A 1 536 ? -20.381 -40.832 -26.285 1.00 115.76 ? 799  ALA A CB  1 
ATOM   3892 N  N   . THR A 1 537 ? -22.654 -42.677 -25.878 1.00 99.28  ? 800  THR A N   1 
ATOM   3893 C  CA  . THR A 1 537 ? -23.806 -43.520 -26.290 1.00 83.99  ? 800  THR A CA  1 
ATOM   3894 C  C   . THR A 1 537 ? -23.951 -44.685 -25.302 1.00 83.70  ? 800  THR A C   1 
ATOM   3895 O  O   . THR A 1 537 ? -22.938 -45.399 -25.043 1.00 86.25  ? 800  THR A O   1 
ATOM   3896 C  CB  . THR A 1 537 ? -23.604 -44.060 -27.705 1.00 82.17  ? 800  THR A CB  1 
ATOM   3897 O  OG1 . THR A 1 537 ? -22.648 -45.108 -27.556 1.00 98.75  ? 800  THR A OG1 1 
ATOM   3898 C  CG2 . THR A 1 537 ? -23.140 -43.006 -28.685 1.00 80.01  ? 800  THR A CG2 1 
ATOM   3899 N  N   A HIS A 1 538 ? -25.164 -44.891 -24.780 0.14 74.43  ? 801  HIS A N   1 
ATOM   3900 N  N   B HIS A 1 538 ? -25.170 -44.876 -24.778 0.14 75.43  ? 801  HIS A N   1 
ATOM   3901 C  CA  A HIS A 1 538 ? -25.469 -45.880 -23.711 0.14 65.95  ? 801  HIS A CA  1 
ATOM   3902 C  CA  B HIS A 1 538 ? -25.509 -45.856 -23.709 0.14 67.38  ? 801  HIS A CA  1 
ATOM   3903 C  C   A HIS A 1 538 ? -26.486 -46.905 -24.232 0.14 57.65  ? 801  HIS A C   1 
ATOM   3904 C  C   B HIS A 1 538 ? -26.503 -46.896 -24.245 0.14 58.39  ? 801  HIS A C   1 
ATOM   3905 O  O   A HIS A 1 538 ? -27.591 -46.995 -23.658 0.14 53.40  ? 801  HIS A O   1 
ATOM   3906 O  O   B HIS A 1 538 ? -27.617 -46.993 -23.689 0.14 54.12  ? 801  HIS A O   1 
ATOM   3907 C  CB  A HIS A 1 538 ? -25.892 -45.134 -22.438 0.14 66.49  ? 801  HIS A CB  1 
ATOM   3908 C  CB  B HIS A 1 538 ? -26.012 -45.132 -22.446 0.14 68.99  ? 801  HIS A CB  1 
ATOM   3909 C  CG  A HIS A 1 538 ? -24.756 -44.440 -21.761 0.14 66.39  ? 801  HIS A CG  1 
ATOM   3910 C  CG  B HIS A 1 538 ? -26.515 -43.743 -22.666 0.14 70.52  ? 801  HIS A CG  1 
ATOM   3911 N  ND1 A HIS A 1 538 ? -24.489 -44.601 -20.416 0.14 66.78  ? 801  HIS A ND1 1 
ATOM   3912 N  ND1 B HIS A 1 538 ? -26.094 -42.676 -21.890 0.14 70.75  ? 801  HIS A ND1 1 
ATOM   3913 C  CD2 A HIS A 1 538 ? -23.804 -43.605 -22.237 0.14 66.49  ? 801  HIS A CD2 1 
ATOM   3914 C  CD2 B HIS A 1 538 ? -27.399 -43.239 -23.555 0.14 70.50  ? 801  HIS A CD2 1 
ATOM   3915 C  CE1 A HIS A 1 538 ? -23.431 -43.886 -20.090 0.14 68.31  ? 801  HIS A CE1 1 
ATOM   3916 C  CE1 B HIS A 1 538 ? -26.697 -41.577 -22.295 0.14 70.55  ? 801  HIS A CE1 1 
ATOM   3917 N  NE2 A HIS A 1 538 ? -22.990 -43.267 -21.191 0.14 67.12  ? 801  HIS A NE2 1 
ATOM   3918 N  NE2 B HIS A 1 538 ? -27.504 -41.896 -23.315 0.14 70.45  ? 801  HIS A NE2 1 
ATOM   3919 N  N   . GLU A 1 539 ? -26.094 -47.669 -25.259 1.00 49.81  ? 802  GLU A N   1 
ATOM   3920 C  CA  . GLU A 1 539 ? -26.959 -48.692 -25.908 1.00 49.79  ? 802  GLU A CA  1 
ATOM   3921 C  C   . GLU A 1 539 ? -27.222 -49.908 -25.014 1.00 44.49  ? 802  GLU A C   1 
ATOM   3922 O  O   . GLU A 1 539 ? -28.109 -50.689 -25.369 1.00 48.21  ? 802  GLU A O   1 
ATOM   3923 C  CB  . GLU A 1 539 ? -26.374 -49.199 -27.210 1.00 53.25  ? 802  GLU A CB  1 
ATOM   3924 C  CG  . GLU A 1 539 ? -26.432 -48.184 -28.322 1.00 62.27  ? 802  GLU A CG  1 
ATOM   3925 C  CD  . GLU A 1 539 ? -25.180 -47.342 -28.386 1.00 70.59  ? 802  GLU A CD  1 
ATOM   3926 O  OE1 . GLU A 1 539 ? -24.960 -46.734 -29.459 1.00 85.75  ? 802  GLU A OE1 1 
ATOM   3927 O  OE2 . GLU A 1 539 ? -24.425 -47.302 -27.365 1.00 73.35  ? 802  GLU A OE2 1 
ATOM   3928 N  N   . TRP A 1 540 ? -26.523 -50.043 -23.892 1.00 36.37  ? 803  TRP A N   1 
ATOM   3929 C  CA  . TRP A 1 540 ? -26.755 -51.120 -22.904 1.00 39.12  ? 803  TRP A CA  1 
ATOM   3930 C  C   . TRP A 1 540 ? -27.905 -50.738 -21.975 1.00 43.38  ? 803  TRP A C   1 
ATOM   3931 O  O   . TRP A 1 540 ? -28.327 -51.593 -21.179 1.00 37.52  ? 803  TRP A O   1 
ATOM   3932 C  CB  . TRP A 1 540 ? -25.440 -51.425 -22.152 1.00 38.39  ? 803  TRP A CB  1 
ATOM   3933 C  CG  . TRP A 1 540 ? -24.821 -50.275 -21.428 1.00 34.82  ? 803  TRP A CG  1 
ATOM   3934 C  CD1 . TRP A 1 540 ? -25.120 -49.879 -20.158 1.00 32.88  ? 803  TRP A CD1 1 
ATOM   3935 C  CD2 . TRP A 1 540 ? -23.802 -49.374 -21.910 1.00 33.46  ? 803  TRP A CD2 1 
ATOM   3936 N  NE1 . TRP A 1 540 ? -24.385 -48.773 -19.824 1.00 38.28  ? 803  TRP A NE1 1 
ATOM   3937 C  CE2 . TRP A 1 540 ? -23.546 -48.454 -20.870 1.00 37.08  ? 803  TRP A CE2 1 
ATOM   3938 C  CE3 . TRP A 1 540 ? -23.093 -49.234 -23.112 1.00 36.52  ? 803  TRP A CE3 1 
ATOM   3939 C  CZ2 . TRP A 1 540 ? -22.580 -47.446 -20.989 1.00 41.54  ? 803  TRP A CZ2 1 
ATOM   3940 C  CZ3 . TRP A 1 540 ? -22.145 -48.244 -23.232 1.00 39.36  ? 803  TRP A CZ3 1 
ATOM   3941 C  CH2 . TRP A 1 540 ? -21.879 -47.373 -22.175 1.00 40.44  ? 803  TRP A CH2 1 
ATOM   3942 N  N   . MET A 1 541 ? -28.385 -49.487 -22.041 1.00 44.32  ? 804  MET A N   1 
ATOM   3943 C  CA  . MET A 1 541 ? -29.449 -49.008 -21.126 1.00 44.58  ? 804  MET A CA  1 
ATOM   3944 C  C   . MET A 1 541 ? -30.806 -49.331 -21.786 1.00 44.22  ? 804  MET A C   1 
ATOM   3945 O  O   . MET A 1 541 ? -31.372 -48.440 -22.439 1.00 45.81  ? 804  MET A O   1 
ATOM   3946 C  CB  . MET A 1 541 ? -29.330 -47.500 -20.846 1.00 49.14  ? 804  MET A CB  1 
ATOM   3947 C  CG  . MET A 1 541 ? -28.129 -47.092 -20.025 1.00 50.45  ? 804  MET A CG  1 
ATOM   3948 S  SD  . MET A 1 541 ? -27.912 -48.031 -18.485 1.00 51.94  ? 804  MET A SD  1 
ATOM   3949 C  CE  . MET A 1 541 ? -29.196 -47.344 -17.437 1.00 55.47  ? 804  MET A CE  1 
ATOM   3950 N  N   . THR A 1 542 ? -31.265 -50.580 -21.671 1.00 40.88  ? 805  THR A N   1 
ATOM   3951 C  CA  . THR A 1 542 ? -32.429 -51.140 -22.407 1.00 43.73  ? 805  THR A CA  1 
ATOM   3952 C  C   . THR A 1 542 ? -32.783 -52.499 -21.815 1.00 46.14  ? 805  THR A C   1 
ATOM   3953 O  O   . THR A 1 542 ? -31.915 -53.131 -21.129 1.00 39.27  ? 805  THR A O   1 
ATOM   3954 C  CB  . THR A 1 542 ? -32.185 -51.323 -23.918 1.00 52.55  ? 805  THR A CB  1 
ATOM   3955 O  OG1 . THR A 1 542 ? -33.260 -52.038 -24.545 1.00 47.82  ? 805  THR A OG1 1 
ATOM   3956 C  CG2 . THR A 1 542 ? -30.916 -52.100 -24.215 1.00 55.06  ? 805  THR A CG2 1 
ATOM   3957 N  N   . THR A 1 543 ? -34.004 -52.958 -22.075 1.00 39.79  ? 806  THR A N   1 
ATOM   3958 C  CA  . THR A 1 543 ? -34.436 -54.331 -21.705 1.00 44.66  ? 806  THR A CA  1 
ATOM   3959 C  C   . THR A 1 543 ? -34.493 -55.177 -22.976 1.00 38.74  ? 806  THR A C   1 
ATOM   3960 O  O   . THR A 1 543 ? -34.819 -56.349 -22.868 1.00 39.91  ? 806  THR A O   1 
ATOM   3961 C  CB  . THR A 1 543 ? -35.758 -54.302 -20.925 1.00 52.82  ? 806  THR A CB  1 
ATOM   3962 O  OG1 . THR A 1 543 ? -36.526 -53.255 -21.513 1.00 49.09  ? 806  THR A OG1 1 
ATOM   3963 C  CG2 . THR A 1 543 ? -35.562 -54.042 -19.445 1.00 58.12  ? 806  THR A CG2 1 
ATOM   3964 N  N   . GLU A 1 544 ? -34.147 -54.632 -24.135 1.00 38.07  ? 807  GLU A N   1 
ATOM   3965 C  CA  . GLU A 1 544 ? -34.023 -55.464 -25.360 1.00 39.22  ? 807  GLU A CA  1 
ATOM   3966 C  C   . GLU A 1 544 ? -32.972 -56.553 -25.125 1.00 41.52  ? 807  GLU A C   1 
ATOM   3967 O  O   . GLU A 1 544 ? -32.100 -56.400 -24.208 1.00 39.50  ? 807  GLU A O   1 
ATOM   3968 C  CB  . GLU A 1 544 ? -33.679 -54.574 -26.539 1.00 44.51  ? 807  GLU A CB  1 
ATOM   3969 C  CG  . GLU A 1 544 ? -33.644 -55.305 -27.849 1.00 51.69  ? 807  GLU A CG  1 
ATOM   3970 C  CD  . GLU A 1 544 ? -33.672 -54.336 -29.025 1.00 58.73  ? 807  GLU A CD  1 
ATOM   3971 O  OE1 . GLU A 1 544 ? -34.155 -54.734 -30.121 1.00 57.37  ? 807  GLU A OE1 1 
ATOM   3972 O  OE2 . GLU A 1 544 ? -33.225 -53.170 -28.843 1.00 49.46  ? 807  GLU A OE2 1 
ATOM   3973 N  N   . ASP A 1 545 ? -33.067 -57.651 -25.871 1.00 45.64  ? 808  ASP A N   1 
ATOM   3974 C  CA  . ASP A 1 545 ? -32.114 -58.791 -25.817 1.00 47.82  ? 808  ASP A CA  1 
ATOM   3975 C  C   . ASP A 1 545 ? -30.704 -58.287 -26.200 1.00 48.21  ? 808  ASP A C   1 
ATOM   3976 O  O   . ASP A 1 545 ? -30.564 -57.623 -27.249 1.00 41.71  ? 808  ASP A O   1 
ATOM   3977 C  CB  . ASP A 1 545 ? -32.568 -59.921 -26.751 1.00 54.20  ? 808  ASP A CB  1 
ATOM   3978 C  CG  . ASP A 1 545 ? -31.510 -60.974 -27.031 1.00 66.83  ? 808  ASP A CG  1 
ATOM   3979 O  OD1 . ASP A 1 545 ? -30.530 -60.628 -27.716 1.00 94.53  ? 808  ASP A OD1 1 
ATOM   3980 O  OD2 . ASP A 1 545 ? -31.664 -62.126 -26.564 1.00 87.98  ? 808  ASP A OD2 1 
ATOM   3981 N  N   . MET A 1 546 ? -29.679 -58.636 -25.417 1.00 42.41  ? 809  MET A N   1 
ATOM   3982 C  CA  . MET A 1 546 ? -28.306 -58.081 -25.636 1.00 40.64  ? 809  MET A CA  1 
ATOM   3983 C  C   . MET A 1 546 ? -27.721 -58.627 -26.940 1.00 35.50  ? 809  MET A C   1 
ATOM   3984 O  O   . MET A 1 546 ? -27.098 -57.816 -27.620 1.00 35.86  ? 809  MET A O   1 
ATOM   3985 C  CB  . MET A 1 546 ? -27.388 -58.318 -24.436 1.00 41.07  ? 809  MET A CB  1 
ATOM   3986 C  CG  . MET A 1 546 ? -27.686 -57.356 -23.264 1.00 41.89  ? 809  MET A CG  1 
ATOM   3987 S  SD  . MET A 1 546 ? -27.444 -55.591 -23.685 1.00 51.99  ? 809  MET A SD  1 
ATOM   3988 C  CE  . MET A 1 546 ? -29.117 -55.080 -24.042 1.00 60.28  ? 809  MET A CE  1 
ATOM   3989 N  N   . LEU A 1 547 ? -27.994 -59.873 -27.365 1.00 31.99  ? 810  LEU A N   1 
ATOM   3990 C  CA  . LEU A 1 547 ? -27.500 -60.296 -28.711 1.00 32.49  ? 810  LEU A CA  1 
ATOM   3991 C  C   . LEU A 1 547 ? -28.055 -59.365 -29.787 1.00 38.81  ? 810  LEU A C   1 
ATOM   3992 O  O   . LEU A 1 547 ? -27.303 -59.071 -30.736 1.00 38.16  ? 810  LEU A O   1 
ATOM   3993 C  CB  . LEU A 1 547 ? -27.862 -61.728 -29.061 1.00 36.16  ? 810  LEU A CB  1 
ATOM   3994 C  CG  . LEU A 1 547 ? -27.194 -62.250 -30.330 1.00 40.47  ? 810  LEU A CG  1 
ATOM   3995 C  CD1 . LEU A 1 547 ? -25.678 -62.165 -30.236 1.00 43.86  ? 810  LEU A CD1 1 
ATOM   3996 C  CD2 . LEU A 1 547 ? -27.589 -63.686 -30.577 1.00 42.14  ? 810  LEU A CD2 1 
ATOM   3997 N  N   . THR A 1 548 ? -29.318 -58.939 -29.679 1.00 36.29  ? 811  THR A N   1 
ATOM   3998 C  CA  . THR A 1 548 ? -29.939 -58.075 -30.709 1.00 36.96  ? 811  THR A CA  1 
ATOM   3999 C  C   . THR A 1 548 ? -29.245 -56.707 -30.720 1.00 33.79  ? 811  THR A C   1 
ATOM   4000 O  O   . THR A 1 548 ? -28.967 -56.218 -31.809 1.00 32.68  ? 811  THR A O   1 
ATOM   4001 C  CB  . THR A 1 548 ? -31.454 -57.941 -30.514 1.00 41.14  ? 811  THR A CB  1 
ATOM   4002 O  OG1 . THR A 1 548 ? -31.983 -59.253 -30.694 1.00 46.40  ? 811  THR A OG1 1 
ATOM   4003 C  CG2 . THR A 1 548 ? -32.095 -56.964 -31.480 1.00 38.95  ? 811  THR A CG2 1 
ATOM   4004 N  N   . VAL A 1 549 ? -29.066 -56.073 -29.571 1.00 30.63  ? 812  VAL A N   1 
ATOM   4005 C  CA  . VAL A 1 549 ? -28.305 -54.798 -29.464 1.00 39.07  ? 812  VAL A CA  1 
ATOM   4006 C  C   . VAL A 1 549 ? -26.859 -54.965 -29.983 1.00 35.49  ? 812  VAL A C   1 
ATOM   4007 O  O   . VAL A 1 549 ? -26.391 -54.101 -30.737 1.00 38.18  ? 812  VAL A O   1 
ATOM   4008 C  CB  . VAL A 1 549 ? -28.276 -54.289 -28.018 1.00 43.36  ? 812  VAL A CB  1 
ATOM   4009 C  CG1 . VAL A 1 549 ? -27.448 -53.002 -27.949 1.00 41.71  ? 812  VAL A CG1 1 
ATOM   4010 C  CG2 . VAL A 1 549 ? -29.698 -54.098 -27.496 1.00 49.44  ? 812  VAL A CG2 1 
ATOM   4011 N  N   . TRP A 1 550 ? -26.180 -56.054 -29.629 1.00 38.04  ? 813  TRP A N   1 
ATOM   4012 C  CA  . TRP A 1 550 ? -24.809 -56.342 -30.153 1.00 38.10  ? 813  TRP A CA  1 
ATOM   4013 C  C   . TRP A 1 550 ? -24.819 -56.296 -31.688 1.00 40.29  ? 813  TRP A C   1 
ATOM   4014 O  O   . TRP A 1 550 ? -23.921 -55.655 -32.268 1.00 36.62  ? 813  TRP A O   1 
ATOM   4015 C  CB  . TRP A 1 550 ? -24.258 -57.664 -29.613 1.00 33.95  ? 813  TRP A CB  1 
ATOM   4016 C  CG  . TRP A 1 550 ? -22.797 -57.838 -29.897 1.00 33.54  ? 813  TRP A CG  1 
ATOM   4017 C  CD1 . TRP A 1 550 ? -21.781 -57.684 -28.997 1.00 35.33  ? 813  TRP A CD1 1 
ATOM   4018 C  CD2 . TRP A 1 550 ? -22.176 -58.230 -31.134 1.00 34.69  ? 813  TRP A CD2 1 
ATOM   4019 N  NE1 . TRP A 1 550 ? -20.567 -57.906 -29.596 1.00 42.83  ? 813  TRP A NE1 1 
ATOM   4020 C  CE2 . TRP A 1 550 ? -20.773 -58.222 -30.914 1.00 38.54  ? 813  TRP A CE2 1 
ATOM   4021 C  CE3 . TRP A 1 550 ? -22.647 -58.615 -32.391 1.00 35.27  ? 813  TRP A CE3 1 
ATOM   4022 C  CZ2 . TRP A 1 550 ? -19.854 -58.558 -31.894 1.00 33.65  ? 813  TRP A CZ2 1 
ATOM   4023 C  CZ3 . TRP A 1 550 ? -21.730 -58.920 -33.376 1.00 37.15  ? 813  TRP A CZ3 1 
ATOM   4024 C  CH2 . TRP A 1 550 ? -20.358 -58.893 -33.129 1.00 38.39  ? 813  TRP A CH2 1 
ATOM   4025 N  N   . ASN A 1 551 ? -25.794 -56.948 -32.327 1.00 42.09  ? 814  ASN A N   1 
ATOM   4026 C  CA  . ASN A 1 551 ? -25.881 -57.040 -33.808 1.00 42.50  ? 814  ASN A CA  1 
ATOM   4027 C  C   . ASN A 1 551 ? -26.115 -55.630 -34.357 1.00 41.18  ? 814  ASN A C   1 
ATOM   4028 O  O   . ASN A 1 551 ? -25.525 -55.270 -35.405 1.00 39.91  ? 814  ASN A O   1 
ATOM   4029 C  CB  . ASN A 1 551 ? -26.945 -58.052 -34.269 1.00 47.52  ? 814  ASN A CB  1 
ATOM   4030 C  CG  . ASN A 1 551 ? -26.400 -59.457 -34.454 1.00 49.23  ? 814  ASN A CG  1 
ATOM   4031 O  OD1 . ASN A 1 551 ? -25.477 -59.659 -35.234 1.00 45.61  ? 814  ASN A OD1 1 
ATOM   4032 N  ND2 . ASN A 1 551 ? -26.957 -60.435 -33.749 1.00 48.52  ? 814  ASN A ND2 1 
ATOM   4033 N  N   . ARG A 1 552 ? -26.956 -54.843 -33.695 1.00 39.85  ? 815  ARG A N   1 
ATOM   4034 C  CA  . ARG A 1 552 ? -27.250 -53.467 -34.174 1.00 44.06  ? 815  ARG A CA  1 
ATOM   4035 C  C   . ARG A 1 552 ? -25.951 -52.628 -34.149 1.00 46.42  ? 815  ARG A C   1 
ATOM   4036 O  O   . ARG A 1 552 ? -25.610 -51.936 -35.196 1.00 39.81  ? 815  ARG A O   1 
ATOM   4037 C  CB  . ARG A 1 552 ? -28.341 -52.841 -33.304 1.00 41.92  ? 815  ARG A CB  1 
ATOM   4038 C  CG  . ARG A 1 552 ? -28.843 -51.498 -33.822 1.00 45.96  ? 815  ARG A CG  1 
ATOM   4039 C  CD  . ARG A 1 552 ? -29.950 -50.889 -32.968 1.00 48.91  ? 815  ARG A CD  1 
ATOM   4040 N  NE  . ARG A 1 552 ? -31.033 -51.864 -32.859 1.00 59.97  ? 815  ARG A NE  1 
ATOM   4041 C  CZ  . ARG A 1 552 ? -31.621 -52.303 -31.736 1.00 61.23  ? 815  ARG A CZ  1 
ATOM   4042 N  NH1 . ARG A 1 552 ? -31.294 -51.833 -30.539 1.00 56.22  ? 815  ARG A NH1 1 
ATOM   4043 N  NH2 . ARG A 1 552 ? -32.574 -53.216 -31.844 1.00 64.94  ? 815  ARG A NH2 1 
ATOM   4044 N  N   . VAL A 1 553 ? -25.252 -52.660 -33.000 1.00 38.05  ? 816  VAL A N   1 
ATOM   4045 C  CA  . VAL A 1 553 ? -24.109 -51.742 -32.703 1.00 39.10  ? 816  VAL A CA  1 
ATOM   4046 C  C   . VAL A 1 553 ? -22.867 -52.143 -33.521 1.00 34.61  ? 816  VAL A C   1 
ATOM   4047 O  O   . VAL A 1 553 ? -22.232 -51.249 -34.123 1.00 40.12  ? 816  VAL A O   1 
ATOM   4048 C  CB  . VAL A 1 553 ? -23.839 -51.701 -31.191 1.00 39.45  ? 816  VAL A CB  1 
ATOM   4049 C  CG1 . VAL A 1 553 ? -22.521 -51.032 -30.898 1.00 39.55  ? 816  VAL A CG1 1 
ATOM   4050 C  CG2 . VAL A 1 553 ? -24.968 -50.999 -30.448 1.00 34.45  ? 816  VAL A CG2 1 
ATOM   4051 N  N   . TRP A 1 554 ? -22.562 -53.438 -33.579 1.00 35.10  ? 817  TRP A N   1 
ATOM   4052 C  CA  . TRP A 1 554 ? -21.273 -53.974 -34.086 1.00 32.20  ? 817  TRP A CA  1 
ATOM   4053 C  C   . TRP A 1 554 ? -21.392 -54.311 -35.573 1.00 36.59  ? 817  TRP A C   1 
ATOM   4054 O  O   . TRP A 1 554 ? -20.334 -54.314 -36.236 1.00 36.76  ? 817  TRP A O   1 
ATOM   4055 C  CB  . TRP A 1 554 ? -20.776 -55.143 -33.217 1.00 32.06  ? 817  TRP A CB  1 
ATOM   4056 C  CG  . TRP A 1 554 ? -20.234 -54.677 -31.899 1.00 32.52  ? 817  TRP A CG  1 
ATOM   4057 C  CD1 . TRP A 1 554 ? -20.792 -54.827 -30.659 1.00 30.87  ? 817  TRP A CD1 1 
ATOM   4058 C  CD2 . TRP A 1 554 ? -18.991 -53.950 -31.696 1.00 29.67  ? 817  TRP A CD2 1 
ATOM   4059 N  NE1 . TRP A 1 554 ? -19.975 -54.255 -29.701 1.00 31.55  ? 817  TRP A NE1 1 
ATOM   4060 C  CE2 . TRP A 1 554 ? -18.873 -53.689 -30.315 1.00 31.10  ? 817  TRP A CE2 1 
ATOM   4061 C  CE3 . TRP A 1 554 ? -17.954 -53.546 -32.532 1.00 28.33  ? 817  TRP A CE3 1 
ATOM   4062 C  CZ2 . TRP A 1 554 ? -17.768 -53.017 -29.776 1.00 30.89  ? 817  TRP A CZ2 1 
ATOM   4063 C  CZ3 . TRP A 1 554 ? -16.872 -52.847 -32.003 1.00 30.26  ? 817  TRP A CZ3 1 
ATOM   4064 C  CH2 . TRP A 1 554 ? -16.791 -52.579 -30.640 1.00 27.07  ? 817  TRP A CH2 1 
ATOM   4065 N  N   . ILE A 1 555 ? -22.612 -54.539 -36.105 1.00 38.29  ? 818  ILE A N   1 
ATOM   4066 C  CA  . ILE A 1 555 ? -22.795 -54.998 -37.523 1.00 38.30  ? 818  ILE A CA  1 
ATOM   4067 C  C   . ILE A 1 555 ? -23.629 -53.962 -38.275 1.00 41.46  ? 818  ILE A C   1 
ATOM   4068 O  O   . ILE A 1 555 ? -23.079 -53.269 -39.129 1.00 34.57  ? 818  ILE A O   1 
ATOM   4069 C  CB  . ILE A 1 555 ? -23.436 -56.397 -37.638 1.00 42.30  ? 818  ILE A CB  1 
ATOM   4070 C  CG1 . ILE A 1 555 ? -22.742 -57.460 -36.787 1.00 41.14  ? 818  ILE A CG1 1 
ATOM   4071 C  CG2 . ILE A 1 555 ? -23.493 -56.828 -39.099 1.00 43.48  ? 818  ILE A CG2 1 
ATOM   4072 C  CD1 . ILE A 1 555 ? -21.289 -57.610 -37.088 1.00 43.05  ? 818  ILE A CD1 1 
ATOM   4073 N  N   . GLN A 1 556 ? -24.916 -53.849 -37.932 1.00 44.58  ? 819  GLN A N   1 
ATOM   4074 C  CA  . GLN A 1 556 ? -25.929 -53.100 -38.722 1.00 43.22  ? 819  GLN A CA  1 
ATOM   4075 C  C   . GLN A 1 556 ? -25.501 -51.641 -38.819 1.00 37.25  ? 819  GLN A C   1 
ATOM   4076 O  O   . GLN A 1 556 ? -25.350 -51.173 -39.916 1.00 41.97  ? 819  GLN A O   1 
ATOM   4077 C  CB  . GLN A 1 556 ? -27.305 -53.319 -38.084 1.00 48.92  ? 819  GLN A CB  1 
ATOM   4078 C  CG  . GLN A 1 556 ? -28.473 -52.766 -38.877 1.00 58.09  ? 819  GLN A CG  1 
ATOM   4079 C  CD  . GLN A 1 556 ? -29.718 -52.704 -38.019 1.00 69.47  ? 819  GLN A CD  1 
ATOM   4080 O  OE1 . GLN A 1 556 ? -30.415 -51.694 -38.006 1.00 75.10  ? 819  GLN A OE1 1 
ATOM   4081 N  NE2 . GLN A 1 556 ? -29.982 -53.756 -37.249 1.00 68.43  ? 819  GLN A NE2 1 
ATOM   4082 N  N   . GLU A 1 557 ? -25.269 -50.969 -37.700 1.00 35.30  ? 820  GLU A N   1 
ATOM   4083 C  CA  . GLU A 1 557 ? -25.020 -49.510 -37.664 1.00 42.15  ? 820  GLU A CA  1 
ATOM   4084 C  C   . GLU A 1 557 ? -23.505 -49.206 -37.720 1.00 40.34  ? 820  GLU A C   1 
ATOM   4085 O  O   . GLU A 1 557 ? -23.146 -48.010 -37.624 1.00 42.37  ? 820  GLU A O   1 
ATOM   4086 C  CB  . GLU A 1 557 ? -25.664 -48.893 -36.414 1.00 46.30  ? 820  GLU A CB  1 
ATOM   4087 C  CG  . GLU A 1 557 ? -27.201 -48.975 -36.378 1.00 56.48  ? 820  GLU A CG  1 
ATOM   4088 C  CD  . GLU A 1 557 ? -27.845 -48.333 -35.140 1.00 70.02  ? 820  GLU A CD  1 
ATOM   4089 O  OE1 . GLU A 1 557 ? -27.113 -48.103 -34.128 1.00 80.38  ? 820  GLU A OE1 1 
ATOM   4090 O  OE2 . GLU A 1 557 ? -29.084 -48.069 -35.159 1.00 76.97  ? 820  GLU A OE2 1 
ATOM   4091 N  N   . ASN A 1 558 ? -22.644 -50.206 -37.913 1.00 39.05  ? 821  ASN A N   1 
ATOM   4092 C  CA  . ASN A 1 558 ? -21.158 -50.041 -37.847 1.00 39.79  ? 821  ASN A CA  1 
ATOM   4093 C  C   . ASN A 1 558 ? -20.663 -49.671 -39.240 1.00 38.49  ? 821  ASN A C   1 
ATOM   4094 O  O   . ASN A 1 558 ? -20.620 -50.521 -40.113 1.00 36.33  ? 821  ASN A O   1 
ATOM   4095 C  CB  . ASN A 1 558 ? -20.503 -51.311 -37.287 1.00 36.33  ? 821  ASN A CB  1 
ATOM   4096 C  CG  . ASN A 1 558 ? -18.984 -51.309 -37.296 1.00 35.33  ? 821  ASN A CG  1 
ATOM   4097 O  OD1 . ASN A 1 558 ? -18.362 -50.393 -37.817 1.00 33.22  ? 821  ASN A OD1 1 
ATOM   4098 N  ND2 . ASN A 1 558 ? -18.386 -52.379 -36.772 1.00 34.10  ? 821  ASN A ND2 1 
ATOM   4099 N  N   . PRO A 1 559 ? -20.294 -48.404 -39.520 1.00 41.30  ? 822  PRO A N   1 
ATOM   4100 C  CA  . PRO A 1 559 ? -19.937 -48.017 -40.884 1.00 44.33  ? 822  PRO A CA  1 
ATOM   4101 C  C   . PRO A 1 559 ? -18.601 -48.578 -41.384 1.00 46.53  ? 822  PRO A C   1 
ATOM   4102 O  O   . PRO A 1 559 ? -18.293 -48.336 -42.523 1.00 46.85  ? 822  PRO A O   1 
ATOM   4103 C  CB  . PRO A 1 559 ? -19.811 -46.489 -40.827 1.00 48.03  ? 822  PRO A CB  1 
ATOM   4104 C  CG  . PRO A 1 559 ? -19.527 -46.216 -39.355 1.00 47.33  ? 822  PRO A CG  1 
ATOM   4105 C  CD  . PRO A 1 559 ? -20.310 -47.264 -38.591 1.00 39.86  ? 822  PRO A CD  1 
ATOM   4106 N  N   . TRP A 1 560 ? -17.838 -49.263 -40.530 1.00 43.67  ? 823  TRP A N   1 
ATOM   4107 C  CA  . TRP A 1 560 ? -16.543 -49.911 -40.904 1.00 43.66  ? 823  TRP A CA  1 
ATOM   4108 C  C   . TRP A 1 560 ? -16.731 -51.399 -41.234 1.00 46.66  ? 823  TRP A C   1 
ATOM   4109 O  O   . TRP A 1 560 ? -15.746 -51.993 -41.630 1.00 46.86  ? 823  TRP A O   1 
ATOM   4110 C  CB  . TRP A 1 560 ? -15.550 -49.737 -39.767 1.00 41.99  ? 823  TRP A CB  1 
ATOM   4111 C  CG  . TRP A 1 560 ? -15.066 -48.328 -39.640 1.00 38.47  ? 823  TRP A CG  1 
ATOM   4112 C  CD1 . TRP A 1 560 ? -14.117 -47.721 -40.402 1.00 33.61  ? 823  TRP A CD1 1 
ATOM   4113 C  CD2 . TRP A 1 560 ? -15.552 -47.333 -38.716 1.00 37.42  ? 823  TRP A CD2 1 
ATOM   4114 N  NE1 . TRP A 1 560 ? -13.936 -46.433 -39.972 1.00 38.69  ? 823  TRP A NE1 1 
ATOM   4115 C  CE2 . TRP A 1 560 ? -14.819 -46.156 -38.953 1.00 37.49  ? 823  TRP A CE2 1 
ATOM   4116 C  CE3 . TRP A 1 560 ? -16.469 -47.343 -37.662 1.00 35.93  ? 823  TRP A CE3 1 
ATOM   4117 C  CZ2 . TRP A 1 560 ? -14.996 -45.002 -38.189 1.00 34.84  ? 823  TRP A CZ2 1 
ATOM   4118 C  CZ3 . TRP A 1 560 ? -16.663 -46.193 -36.929 1.00 36.25  ? 823  TRP A CZ3 1 
ATOM   4119 C  CH2 . TRP A 1 560 ? -15.939 -45.031 -37.192 1.00 35.38  ? 823  TRP A CH2 1 
ATOM   4120 N  N   . MET A 1 561 ? -17.955 -51.947 -41.097 1.00 47.09  ? 824  MET A N   1 
ATOM   4121 C  CA  . MET A 1 561 ? -18.337 -53.344 -41.465 1.00 48.15  ? 824  MET A CA  1 
ATOM   4122 C  C   . MET A 1 561 ? -19.133 -53.321 -42.785 1.00 49.47  ? 824  MET A C   1 
ATOM   4123 O  O   . MET A 1 561 ? -20.256 -52.822 -42.761 1.00 47.69  ? 824  MET A O   1 
ATOM   4124 C  CB  . MET A 1 561 ? -19.199 -53.933 -40.343 1.00 49.63  ? 824  MET A CB  1 
ATOM   4125 C  CG  . MET A 1 561 ? -19.375 -55.433 -40.379 1.00 53.41  ? 824  MET A CG  1 
ATOM   4126 S  SD  . MET A 1 561 ? -17.857 -56.235 -39.852 1.00 70.58  ? 824  MET A SD  1 
ATOM   4127 C  CE  . MET A 1 561 ? -17.961 -56.080 -38.069 1.00 68.38  ? 824  MET A CE  1 
ATOM   4128 N  N   . GLU A 1 562 ? -18.588 -53.824 -43.899 1.00 51.38  ? 825  GLU A N   1 
ATOM   4129 C  CA  . GLU A 1 562 ? -19.306 -53.905 -45.208 1.00 54.49  ? 825  GLU A CA  1 
ATOM   4130 C  C   . GLU A 1 562 ? -20.359 -55.032 -45.198 1.00 50.54  ? 825  GLU A C   1 
ATOM   4131 O  O   . GLU A 1 562 ? -21.481 -54.780 -45.624 1.00 51.20  ? 825  GLU A O   1 
ATOM   4132 C  CB  . GLU A 1 562 ? -18.335 -54.130 -46.365 1.00 61.39  ? 825  GLU A CB  1 
ATOM   4133 C  CG  . GLU A 1 562 ? -18.863 -53.630 -47.700 1.00 74.26  ? 825  GLU A CG  1 
ATOM   4134 C  CD  . GLU A 1 562 ? -17.881 -53.719 -48.864 1.00 92.21  ? 825  GLU A CD  1 
ATOM   4135 O  OE1 . GLU A 1 562 ? -18.351 -53.861 -50.020 1.00 93.64  ? 825  GLU A OE1 1 
ATOM   4136 O  OE2 . GLU A 1 562 ? -16.645 -53.635 -48.623 1.00 101.31 ? 825  GLU A OE2 1 
ATOM   4137 N  N   . ASP A 1 563 ? -20.020 -56.233 -44.746 1.00 46.73  ? 826  ASP A N   1 
ATOM   4138 C  CA  . ASP A 1 563 ? -20.955 -57.385 -44.722 1.00 49.24  ? 826  ASP A CA  1 
ATOM   4139 C  C   . ASP A 1 563 ? -21.856 -57.290 -43.479 1.00 49.74  ? 826  ASP A C   1 
ATOM   4140 O  O   . ASP A 1 563 ? -21.314 -57.309 -42.356 1.00 48.88  ? 826  ASP A O   1 
ATOM   4141 C  CB  . ASP A 1 563 ? -20.173 -58.695 -44.790 1.00 48.76  ? 826  ASP A CB  1 
ATOM   4142 C  CG  . ASP A 1 563 ? -21.005 -59.910 -44.419 1.00 52.45  ? 826  ASP A CG  1 
ATOM   4143 O  OD1 . ASP A 1 563 ? -22.238 -59.752 -44.211 1.00 54.41  ? 826  ASP A OD1 1 
ATOM   4144 O  OD2 . ASP A 1 563 ? -20.404 -60.985 -44.258 1.00 56.45  ? 826  ASP A OD2 1 
ATOM   4145 N  N   . LYS A 1 564 ? -23.179 -57.237 -43.676 1.00 46.78  ? 827  LYS A N   1 
ATOM   4146 C  CA  . LYS A 1 564 ? -24.167 -56.924 -42.607 1.00 42.46  ? 827  LYS A CA  1 
ATOM   4147 C  C   . LYS A 1 564 ? -24.871 -58.193 -42.136 1.00 39.45  ? 827  LYS A C   1 
ATOM   4148 O  O   . LYS A 1 564 ? -25.945 -58.083 -41.501 1.00 41.33  ? 827  LYS A O   1 
ATOM   4149 C  CB  . LYS A 1 564 ? -25.212 -55.914 -43.086 1.00 47.35  ? 827  LYS A CB  1 
ATOM   4150 C  CG  . LYS A 1 564 ? -24.652 -54.591 -43.564 1.00 48.42  ? 827  LYS A CG  1 
ATOM   4151 C  CD  . LYS A 1 564 ? -23.834 -53.894 -42.528 1.00 46.12  ? 827  LYS A CD  1 
ATOM   4152 C  CE  . LYS A 1 564 ? -23.877 -52.394 -42.688 1.00 49.57  ? 827  LYS A CE  1 
ATOM   4153 N  NZ  . LYS A 1 564 ? -22.924 -51.686 -41.797 1.00 49.52  ? 827  LYS A NZ  1 
ATOM   4154 N  N   . THR A 1 565 ? -24.282 -59.357 -42.386 1.00 40.62  ? 828  THR A N   1 
ATOM   4155 C  CA  . THR A 1 565 ? -24.868 -60.653 -41.952 1.00 47.49  ? 828  THR A CA  1 
ATOM   4156 C  C   . THR A 1 565 ? -24.993 -60.667 -40.430 1.00 44.85  ? 828  THR A C   1 
ATOM   4157 O  O   . THR A 1 565 ? -23.980 -60.634 -39.739 1.00 45.37  ? 828  THR A O   1 
ATOM   4158 C  CB  . THR A 1 565 ? -24.007 -61.840 -42.411 1.00 52.31  ? 828  THR A CB  1 
ATOM   4159 O  OG1 . THR A 1 565 ? -23.820 -61.728 -43.823 1.00 55.95  ? 828  THR A OG1 1 
ATOM   4160 C  CG2 . THR A 1 565 ? -24.615 -63.180 -42.055 1.00 51.77  ? 828  THR A CG2 1 
ATOM   4161 N  N   . PRO A 1 566 ? -26.201 -60.810 -39.836 1.00 50.89  ? 829  PRO A N   1 
ATOM   4162 C  CA  . PRO A 1 566 ? -26.302 -60.811 -38.383 1.00 48.73  ? 829  PRO A CA  1 
ATOM   4163 C  C   . PRO A 1 566 ? -25.568 -62.031 -37.822 1.00 49.68  ? 829  PRO A C   1 
ATOM   4164 O  O   . PRO A 1 566 ? -25.460 -63.032 -38.471 1.00 49.32  ? 829  PRO A O   1 
ATOM   4165 C  CB  . PRO A 1 566 ? -27.809 -60.875 -38.082 1.00 51.23  ? 829  PRO A CB  1 
ATOM   4166 C  CG  . PRO A 1 566 ? -28.482 -60.633 -39.411 1.00 49.82  ? 829  PRO A CG  1 
ATOM   4167 C  CD  . PRO A 1 566 ? -27.494 -61.088 -40.468 1.00 47.41  ? 829  PRO A CD  1 
ATOM   4168 N  N   . VAL A 1 567 ? -25.048 -61.901 -36.604 0.50 51.05  ? 830  VAL A N   1 
ATOM   4169 C  CA  . VAL A 1 567 ? -24.554 -63.047 -35.788 0.50 53.02  ? 830  VAL A CA  1 
ATOM   4170 C  C   . VAL A 1 567 ? -25.794 -63.691 -35.154 0.50 52.62  ? 830  VAL A C   1 
ATOM   4171 O  O   . VAL A 1 567 ? -26.744 -62.948 -34.847 0.50 54.50  ? 830  VAL A O   1 
ATOM   4172 C  CB  . VAL A 1 567 ? -23.513 -62.588 -34.746 0.50 53.90  ? 830  VAL A CB  1 
ATOM   4173 C  CG1 . VAL A 1 567 ? -22.995 -63.746 -33.910 0.50 54.96  ? 830  VAL A CG1 1 
ATOM   4174 C  CG2 . VAL A 1 567 ? -22.352 -61.854 -35.395 0.50 52.29  ? 830  VAL A CG2 1 
ATOM   4175 N  N   . GLU A 1 568 ? -25.803 -65.017 -35.007 0.50 52.07  ? 831  GLU A N   1 
ATOM   4176 C  CA  . GLU A 1 568 ? -27.012 -65.795 -34.622 0.50 52.97  ? 831  GLU A CA  1 
ATOM   4177 C  C   . GLU A 1 568 ? -26.815 -66.418 -33.234 0.50 52.62  ? 831  GLU A C   1 
ATOM   4178 O  O   . GLU A 1 568 ? -27.763 -67.056 -32.744 0.50 51.24  ? 831  GLU A O   1 
ATOM   4179 C  CB  . GLU A 1 568 ? -27.305 -66.875 -35.671 0.50 55.05  ? 831  GLU A CB  1 
ATOM   4180 C  CG  . GLU A 1 568 ? -27.395 -66.352 -37.102 0.50 54.44  ? 831  GLU A CG  1 
ATOM   4181 C  CD  . GLU A 1 568 ? -28.685 -65.633 -37.470 0.50 55.98  ? 831  GLU A CD  1 
ATOM   4182 O  OE1 . GLU A 1 568 ? -29.532 -65.428 -36.572 0.50 57.87  ? 831  GLU A OE1 1 
ATOM   4183 O  OE2 . GLU A 1 568 ? -28.849 -65.283 -38.658 0.50 54.81  ? 831  GLU A OE2 1 
ATOM   4184 N  N   . SER A 1 569 ? -25.632 -66.253 -32.627 0.50 49.05  ? 832  SER A N   1 
ATOM   4185 C  CA  . SER A 1 569 ? -25.315 -66.759 -31.264 0.50 46.07  ? 832  SER A CA  1 
ATOM   4186 C  C   . SER A 1 569 ? -24.105 -66.023 -30.677 0.50 44.87  ? 832  SER A C   1 
ATOM   4187 O  O   . SER A 1 569 ? -23.288 -65.492 -31.456 0.50 43.56  ? 832  SER A O   1 
ATOM   4188 C  CB  . SER A 1 569 ? -25.069 -68.240 -31.288 0.50 44.21  ? 832  SER A CB  1 
ATOM   4189 O  OG  . SER A 1 569 ? -23.775 -68.520 -31.793 0.50 44.26  ? 832  SER A OG  1 
ATOM   4190 N  N   . TRP A 1 570 ? -23.983 -66.030 -29.348 1.00 42.66  ? 833  TRP A N   1 
ATOM   4191 C  CA  . TRP A 1 570 ? -22.805 -65.459 -28.644 1.00 44.58  ? 833  TRP A CA  1 
ATOM   4192 C  C   . TRP A 1 570 ? -21.503 -66.232 -28.966 1.00 45.65  ? 833  TRP A C   1 
ATOM   4193 O  O   . TRP A 1 570 ? -20.435 -65.636 -28.978 1.00 41.69  ? 833  TRP A O   1 
ATOM   4194 C  CB  . TRP A 1 570 ? -23.131 -65.417 -27.150 1.00 41.20  ? 833  TRP A CB  1 
ATOM   4195 C  CG  . TRP A 1 570 ? -24.037 -64.291 -26.761 1.00 40.42  ? 833  TRP A CG  1 
ATOM   4196 C  CD1 . TRP A 1 570 ? -25.358 -64.378 -26.449 1.00 37.43  ? 833  TRP A CD1 1 
ATOM   4197 C  CD2 . TRP A 1 570 ? -23.686 -62.894 -26.640 1.00 43.71  ? 833  TRP A CD2 1 
ATOM   4198 N  NE1 . TRP A 1 570 ? -25.848 -63.148 -26.119 1.00 40.57  ? 833  TRP A NE1 1 
ATOM   4199 C  CE2 . TRP A 1 570 ? -24.852 -62.217 -26.226 1.00 35.49  ? 833  TRP A CE2 1 
ATOM   4200 C  CE3 . TRP A 1 570 ? -22.500 -62.153 -26.799 1.00 39.09  ? 833  TRP A CE3 1 
ATOM   4201 C  CZ2 . TRP A 1 570 ? -24.856 -60.857 -25.925 1.00 38.10  ? 833  TRP A CZ2 1 
ATOM   4202 C  CZ3 . TRP A 1 570 ? -22.520 -60.798 -26.537 1.00 40.10  ? 833  TRP A CZ3 1 
ATOM   4203 C  CH2 . TRP A 1 570 ? -23.695 -60.150 -26.140 1.00 42.13  ? 833  TRP A CH2 1 
ATOM   4204 N  N   . GLU A 1 571 ? -21.581 -67.529 -29.276 0.50 46.52  ? 834  GLU A N   1 
ATOM   4205 C  CA  . GLU A 1 571 ? -20.379 -68.362 -29.565 0.50 46.87  ? 834  GLU A CA  1 
ATOM   4206 C  C   . GLU A 1 571 ? -19.697 -67.911 -30.870 0.50 46.27  ? 834  GLU A C   1 
ATOM   4207 O  O   . GLU A 1 571 ? -18.521 -68.278 -31.075 0.50 44.56  ? 834  GLU A O   1 
ATOM   4208 C  CB  . GLU A 1 571 ? -20.746 -69.848 -29.616 0.50 50.30  ? 834  GLU A CB  1 
ATOM   4209 C  CG  . GLU A 1 571 ? -20.905 -70.486 -28.243 0.50 53.18  ? 834  GLU A CG  1 
ATOM   4210 C  CD  . GLU A 1 571 ? -21.220 -71.977 -28.253 0.50 56.66  ? 834  GLU A CD  1 
ATOM   4211 O  OE1 . GLU A 1 571 ? -20.983 -72.635 -29.301 0.50 59.19  ? 834  GLU A OE1 1 
ATOM   4212 O  OE2 . GLU A 1 571 ? -21.702 -72.483 -27.213 0.50 55.53  ? 834  GLU A OE2 1 
ATOM   4213 N  N   . GLU A 1 572 ? -20.380 -67.153 -31.732 0.50 46.05  ? 835  GLU A N   1 
ATOM   4214 C  CA  . GLU A 1 572 ? -19.794 -66.641 -33.005 0.50 46.73  ? 835  GLU A CA  1 
ATOM   4215 C  C   . GLU A 1 572 ? -19.083 -65.304 -32.740 0.50 43.81  ? 835  GLU A C   1 
ATOM   4216 O  O   . GLU A 1 572 ? -18.499 -64.718 -33.686 0.50 38.92  ? 835  GLU A O   1 
ATOM   4217 C  CB  . GLU A 1 572 ? -20.880 -66.482 -34.069 0.50 50.81  ? 835  GLU A CB  1 
ATOM   4218 C  CG  . GLU A 1 572 ? -20.328 -66.415 -35.481 0.50 54.01  ? 835  GLU A CG  1 
ATOM   4219 C  CD  . GLU A 1 572 ? -21.342 -66.038 -36.549 0.50 57.56  ? 835  GLU A CD  1 
ATOM   4220 O  OE1 . GLU A 1 572 ? -20.906 -65.605 -37.646 0.50 55.45  ? 835  GLU A OE1 1 
ATOM   4221 O  OE2 . GLU A 1 572 ? -22.565 -66.171 -36.282 0.50 61.66  ? 835  GLU A OE2 1 
ATOM   4222 N  N   . ILE A 1 573 ? -19.144 -64.831 -31.495 0.50 40.38  ? 836  ILE A N   1 
ATOM   4223 C  CA  . ILE A 1 573 ? -18.518 -63.548 -31.063 0.50 40.28  ? 836  ILE A CA  1 
ATOM   4224 C  C   . ILE A 1 573 ? -17.218 -63.894 -30.344 0.50 37.72  ? 836  ILE A C   1 
ATOM   4225 O  O   . ILE A 1 573 ? -17.240 -64.527 -29.287 0.50 37.25  ? 836  ILE A O   1 
ATOM   4226 C  CB  . ILE A 1 573 ? -19.488 -62.728 -30.192 0.50 39.63  ? 836  ILE A CB  1 
ATOM   4227 C  CG1 . ILE A 1 573 ? -20.750 -62.346 -30.968 0.50 41.28  ? 836  ILE A CG1 1 
ATOM   4228 C  CG2 . ILE A 1 573 ? -18.787 -61.510 -29.623 0.50 41.84  ? 836  ILE A CG2 1 
ATOM   4229 C  CD1 . ILE A 1 573 ? -21.804 -61.643 -30.138 0.50 39.76  ? 836  ILE A CD1 1 
ATOM   4230 N  N   . PRO A 1 574 ? -16.050 -63.498 -30.894 1.00 37.21  ? 837  PRO A N   1 
ATOM   4231 C  CA  . PRO A 1 574 ? -14.763 -63.985 -30.383 1.00 36.22  ? 837  PRO A CA  1 
ATOM   4232 C  C   . PRO A 1 574 ? -14.241 -63.328 -29.104 1.00 34.19  ? 837  PRO A C   1 
ATOM   4233 O  O   . PRO A 1 574 ? -14.760 -62.320 -28.689 1.00 33.28  ? 837  PRO A O   1 
ATOM   4234 C  CB  . PRO A 1 574 ? -13.813 -63.648 -31.528 1.00 38.59  ? 837  PRO A CB  1 
ATOM   4235 C  CG  . PRO A 1 574 ? -14.409 -62.373 -32.123 1.00 42.93  ? 837  PRO A CG  1 
ATOM   4236 C  CD  . PRO A 1 574 ? -15.915 -62.508 -31.971 1.00 40.10  ? 837  PRO A CD  1 
ATOM   4237 N  N   . TYR A 1 575 ? -13.263 -63.977 -28.477 1.00 37.39  ? 838  TYR A N   1 
ATOM   4238 C  CA  . TYR A 1 575 ? -12.481 -63.433 -27.342 1.00 36.69  ? 838  TYR A CA  1 
ATOM   4239 C  C   . TYR A 1 575 ? -11.115 -62.963 -27.894 1.00 35.95  ? 838  TYR A C   1 
ATOM   4240 O  O   . TYR A 1 575 ? -10.739 -63.404 -29.023 1.00 33.37  ? 838  TYR A O   1 
ATOM   4241 C  CB  . TYR A 1 575 ? -12.377 -64.495 -26.253 1.00 33.43  ? 838  TYR A CB  1 
ATOM   4242 C  CG  . TYR A 1 575 ? -13.641 -64.973 -25.594 1.00 39.53  ? 838  TYR A CG  1 
ATOM   4243 C  CD1 . TYR A 1 575 ? -14.253 -64.270 -24.574 1.00 34.32  ? 838  TYR A CD1 1 
ATOM   4244 C  CD2 . TYR A 1 575 ? -14.139 -66.232 -25.890 1.00 41.99  ? 838  TYR A CD2 1 
ATOM   4245 C  CE1 . TYR A 1 575 ? -15.360 -64.773 -23.917 1.00 37.70  ? 838  TYR A CE1 1 
ATOM   4246 C  CE2 . TYR A 1 575 ? -15.240 -66.748 -25.242 1.00 42.85  ? 838  TYR A CE2 1 
ATOM   4247 C  CZ  . TYR A 1 575 ? -15.866 -66.012 -24.265 1.00 39.40  ? 838  TYR A CZ  1 
ATOM   4248 O  OH  . TYR A 1 575 ? -16.970 -66.549 -23.684 1.00 46.62  ? 838  TYR A OH  1 
ATOM   4249 N  N   . LEU A 1 576 ? -10.421 -62.070 -27.171 1.00 29.54  ? 839  LEU A N   1 
ATOM   4250 C  CA  . LEU A 1 576 ? -8.941  -61.871 -27.273 1.00 33.93  ? 839  LEU A CA  1 
ATOM   4251 C  C   . LEU A 1 576 ? -8.246  -63.227 -27.149 1.00 32.56  ? 839  LEU A C   1 
ATOM   4252 O  O   . LEU A 1 576 ? -8.834  -64.129 -26.482 1.00 34.25  ? 839  LEU A O   1 
ATOM   4253 C  CB  . LEU A 1 576 ? -8.440  -60.994 -26.121 1.00 29.87  ? 839  LEU A CB  1 
ATOM   4254 C  CG  . LEU A 1 576 ? -9.002  -59.581 -26.082 1.00 28.59  ? 839  LEU A CG  1 
ATOM   4255 C  CD1 . LEU A 1 576 ? -8.431  -58.806 -24.924 1.00 30.69  ? 839  LEU A CD1 1 
ATOM   4256 C  CD2 . LEU A 1 576 ? -8.736  -58.864 -27.386 1.00 28.85  ? 839  LEU A CD2 1 
ATOM   4257 N  N   . GLY A 1 577 ? -7.025  -63.339 -27.671 1.00 33.59  ? 840  GLY A N   1 
ATOM   4258 C  CA  . GLY A 1 577 ? -6.143  -64.470 -27.352 1.00 30.75  ? 840  GLY A CA  1 
ATOM   4259 C  C   . GLY A 1 577 ? -6.068  -64.628 -25.838 1.00 31.66  ? 840  GLY A C   1 
ATOM   4260 O  O   . GLY A 1 577 ? -6.135  -63.620 -25.104 1.00 28.34  ? 840  GLY A O   1 
ATOM   4261 N  N   . LYS A 1 578 ? -5.920  -65.846 -25.360 1.00 33.68  ? 841  LYS A N   1 
ATOM   4262 C  CA  . LYS A 1 578 ? -5.853  -66.105 -23.905 1.00 38.51  ? 841  LYS A CA  1 
ATOM   4263 C  C   . LYS A 1 578 ? -4.710  -65.321 -23.233 1.00 34.35  ? 841  LYS A C   1 
ATOM   4264 O  O   . LYS A 1 578 ? -4.917  -64.801 -22.078 1.00 34.24  ? 841  LYS A O   1 
ATOM   4265 C  CB  . LYS A 1 578 ? -5.796  -67.605 -23.627 1.00 42.94  ? 841  LYS A CB  1 
ATOM   4266 C  CG  . LYS A 1 578 ? -5.821  -67.967 -22.139 1.00 50.54  ? 841  LYS A CG  1 
ATOM   4267 C  CD  . LYS A 1 578 ? -5.334  -69.389 -21.862 1.00 56.47  ? 841  LYS A CD  1 
ATOM   4268 C  CE  . LYS A 1 578 ? -5.226  -69.727 -20.394 1.00 62.04  ? 841  LYS A CE  1 
ATOM   4269 N  NZ  . LYS A 1 578 ? -4.920  -71.162 -20.188 1.00 62.91  ? 841  LYS A NZ  1 
ATOM   4270 N  N   . ARG A 1 579 ? -3.551  -65.207 -23.891 0.50 31.87  ? 842  ARG A N   1 
ATOM   4271 C  CA  . ARG A 1 579 ? -2.369  -64.532 -23.290 0.50 32.99  ? 842  ARG A CA  1 
ATOM   4272 C  C   . ARG A 1 579 ? -2.646  -63.015 -23.246 0.50 30.58  ? 842  ARG A C   1 
ATOM   4273 O  O   . ARG A 1 579 ? -2.373  -62.350 -22.168 0.50 31.30  ? 842  ARG A O   1 
ATOM   4274 C  CB  . ARG A 1 579 ? -1.066  -64.900 -24.014 0.50 31.51  ? 842  ARG A CB  1 
ATOM   4275 C  CG  . ARG A 1 579 ? 0.184   -64.351 -23.338 0.50 32.97  ? 842  ARG A CG  1 
ATOM   4276 C  CD  . ARG A 1 579 ? 1.478   -64.776 -24.016 0.50 34.66  ? 842  ARG A CD  1 
ATOM   4277 N  NE  . ARG A 1 579 ? 1.423   -66.211 -24.204 0.50 36.24  ? 842  ARG A NE  1 
ATOM   4278 C  CZ  . ARG A 1 579 ? 1.617   -67.080 -23.229 0.50 38.68  ? 842  ARG A CZ  1 
ATOM   4279 N  NH1 . ARG A 1 579 ? 1.488   -68.375 -23.459 0.50 41.87  ? 842  ARG A NH1 1 
ATOM   4280 N  NH2 . ARG A 1 579 ? 1.942   -66.642 -22.029 0.50 38.38  ? 842  ARG A NH2 1 
ATOM   4281 N  N   . GLU A 1 580 ? -3.227  -62.478 -24.338 0.50 31.31  ? 843  GLU A N   1 
ATOM   4282 C  CA  . GLU A 1 580 ? -3.621  -61.045 -24.399 0.50 32.60  ? 843  GLU A CA  1 
ATOM   4283 C  C   . GLU A 1 580 ? -4.667  -60.767 -23.310 0.50 29.62  ? 843  GLU A C   1 
ATOM   4284 O  O   . GLU A 1 580 ? -4.618  -59.688 -22.717 0.50 29.31  ? 843  GLU A O   1 
ATOM   4285 C  CB  . GLU A 1 580 ? -4.169  -60.676 -25.777 0.50 34.37  ? 843  GLU A CB  1 
ATOM   4286 C  CG  . GLU A 1 580 ? -3.145  -60.774 -26.881 0.50 36.71  ? 843  GLU A CG  1 
ATOM   4287 C  CD  . GLU A 1 580 ? -3.681  -60.410 -28.256 0.50 39.76  ? 843  GLU A CD  1 
ATOM   4288 O  OE1 . GLU A 1 580 ? -4.764  -60.921 -28.620 0.50 44.40  ? 843  GLU A OE1 1 
ATOM   4289 O  OE2 . GLU A 1 580 ? -3.020  -59.611 -28.957 0.50 37.57  ? 843  GLU A OE2 1 
ATOM   4290 N  N   . ASP A 1 581 ? -5.571  -61.711 -23.047 0.50 30.24  ? 844  ASP A N   1 
ATOM   4291 C  CA  . ASP A 1 581 ? -6.631  -61.548 -22.015 0.50 30.55  ? 844  ASP A CA  1 
ATOM   4292 C  C   . ASP A 1 581 ? -5.956  -61.417 -20.647 0.50 31.54  ? 844  ASP A C   1 
ATOM   4293 O  O   . ASP A 1 581 ? -6.375  -60.518 -19.871 0.50 31.13  ? 844  ASP A O   1 
ATOM   4294 C  CB  . ASP A 1 581 ? -7.659  -62.680 -22.064 0.50 30.56  ? 844  ASP A CB  1 
ATOM   4295 C  CG  . ASP A 1 581 ? -9.062  -62.298 -21.597 0.50 30.59  ? 844  ASP A CG  1 
ATOM   4296 O  OD1 . ASP A 1 581 ? -9.219  -61.255 -20.918 0.50 28.38  ? 844  ASP A OD1 1 
ATOM   4297 O  OD2 . ASP A 1 581 ? -9.996  -63.065 -21.905 0.50 31.25  ? 844  ASP A OD2 1 
ATOM   4298 N  N   . GLN A 1 582 ? -4.934  -62.243 -20.387 1.00 31.45  ? 845  GLN A N   1 
ATOM   4299 C  CA  . GLN A 1 582 ? -4.175  -62.255 -19.093 1.00 31.35  ? 845  GLN A CA  1 
ATOM   4300 C  C   . GLN A 1 582 ? -3.329  -60.991 -18.962 1.00 27.60  ? 845  GLN A C   1 
ATOM   4301 O  O   . GLN A 1 582 ? -3.306  -60.369 -17.875 1.00 27.52  ? 845  GLN A O   1 
ATOM   4302 C  CB  . GLN A 1 582 ? -3.277  -63.491 -18.985 1.00 31.62  ? 845  GLN A CB  1 
ATOM   4303 C  CG  . GLN A 1 582 ? -4.047  -64.804 -18.923 1.00 34.64  ? 845  GLN A CG  1 
ATOM   4304 C  CD  . GLN A 1 582 ? -3.081  -65.973 -19.003 1.00 40.36  ? 845  GLN A CD  1 
ATOM   4305 O  OE1 . GLN A 1 582 ? -2.027  -65.867 -19.589 1.00 38.54  ? 845  GLN A OE1 1 
ATOM   4306 N  NE2 . GLN A 1 582 ? -3.377  -67.078 -18.356 1.00 41.32  ? 845  GLN A NE2 1 
ATOM   4307 N  N   . TRP A 1 583 ? -2.672  -60.595 -20.040 1.00 27.54  ? 846  TRP A N   1 
ATOM   4308 C  CA  . TRP A 1 583 ? -1.951  -59.297 -20.109 1.00 27.95  ? 846  TRP A CA  1 
ATOM   4309 C  C   . TRP A 1 583 ? -2.872  -58.140 -19.667 1.00 28.53  ? 846  TRP A C   1 
ATOM   4310 O  O   . TRP A 1 583 ? -2.380  -57.200 -18.979 1.00 25.83  ? 846  TRP A O   1 
ATOM   4311 C  CB  . TRP A 1 583 ? -1.429  -59.054 -21.522 1.00 28.69  ? 846  TRP A CB  1 
ATOM   4312 C  CG  . TRP A 1 583 ? -0.207  -59.859 -21.869 1.00 29.11  ? 846  TRP A CG  1 
ATOM   4313 C  CD1 . TRP A 1 583 ? 0.602   -60.549 -21.014 1.00 30.10  ? 846  TRP A CD1 1 
ATOM   4314 C  CD2 . TRP A 1 583 ? 0.254   -60.175 -23.192 1.00 29.37  ? 846  TRP A CD2 1 
ATOM   4315 N  NE1 . TRP A 1 583 ? 1.577   -61.213 -21.713 1.00 31.10  ? 846  TRP A NE1 1 
ATOM   4316 C  CE2 . TRP A 1 583 ? 1.398   -60.990 -23.052 1.00 30.31  ? 846  TRP A CE2 1 
ATOM   4317 C  CE3 . TRP A 1 583 ? -0.129  -59.786 -24.479 1.00 30.45  ? 846  TRP A CE3 1 
ATOM   4318 C  CZ2 . TRP A 1 583 ? 2.118   -61.466 -24.151 1.00 29.23  ? 846  TRP A CZ2 1 
ATOM   4319 C  CZ3 . TRP A 1 583 ? 0.562   -60.276 -25.578 1.00 34.07  ? 846  TRP A CZ3 1 
ATOM   4320 C  CH2 . TRP A 1 583 ? 1.706   -61.080 -25.408 1.00 30.37  ? 846  TRP A CH2 1 
ATOM   4321 N  N   . CYS A 1 584 ? -4.148  -58.134 -20.091 1.00 30.21  ? 847  CYS A N   1 
ATOM   4322 C  CA  . CYS A 1 584 ? -5.084  -57.030 -19.728 1.00 29.32  ? 847  CYS A CA  1 
ATOM   4323 C  C   . CYS A 1 584 ? -5.822  -57.331 -18.414 1.00 27.77  ? 847  CYS A C   1 
ATOM   4324 O  O   . CYS A 1 584 ? -6.802  -56.679 -18.151 1.00 30.44  ? 847  CYS A O   1 
ATOM   4325 C  CB  . CYS A 1 584 ? -5.991  -56.683 -20.893 1.00 29.65  ? 847  CYS A CB  1 
ATOM   4326 S  SG  . CYS A 1 584 ? -5.016  -55.997 -22.237 1.00 33.37  ? 847  CYS A SG  1 
ATOM   4327 N  N   . GLY A 1 585 ? -5.360  -58.299 -17.619 1.00 32.43  ? 848  GLY A N   1 
ATOM   4328 C  CA  . GLY A 1 585 ? -5.814  -58.466 -16.230 1.00 27.33  ? 848  GLY A CA  1 
ATOM   4329 C  C   . GLY A 1 585 ? -6.669  -59.685 -15.976 1.00 28.51  ? 848  GLY A C   1 
ATOM   4330 O  O   . GLY A 1 585 ? -7.078  -59.847 -14.820 1.00 30.70  ? 848  GLY A O   1 
ATOM   4331 N  N   . SER A 1 586 ? -6.951  -60.529 -16.978 1.00 26.98  ? 849  SER A N   1 
ATOM   4332 C  CA  . SER A 1 586 ? -7.781  -61.737 -16.765 1.00 27.55  ? 849  SER A CA  1 
ATOM   4333 C  C   . SER A 1 586 ? -7.184  -62.567 -15.630 1.00 30.37  ? 849  SER A C   1 
ATOM   4334 O  O   . SER A 1 586 ? -5.949  -62.655 -15.547 1.00 32.26  ? 849  SER A O   1 
ATOM   4335 C  CB  . SER A 1 586 ? -7.873  -62.569 -18.002 1.00 28.69  ? 849  SER A CB  1 
ATOM   4336 O  OG  . SER A 1 586 ? -8.702  -63.689 -17.758 1.00 27.71  ? 849  SER A OG  1 
ATOM   4337 N  N   . LEU A 1 587 ? -8.029  -63.225 -14.851 1.00 29.61  ? 850  LEU A N   1 
ATOM   4338 C  CA  . LEU A 1 587 ? -7.636  -64.274 -13.871 1.00 30.99  ? 850  LEU A CA  1 
ATOM   4339 C  C   . LEU A 1 587 ? -7.773  -65.662 -14.505 1.00 30.91  ? 850  LEU A C   1 
ATOM   4340 O  O   . LEU A 1 587 ? -7.614  -66.628 -13.765 1.00 32.74  ? 850  LEU A O   1 
ATOM   4341 C  CB  . LEU A 1 587 ? -8.529  -64.199 -12.635 1.00 30.44  ? 850  LEU A CB  1 
ATOM   4342 C  CG  . LEU A 1 587 ? -8.545  -62.871 -11.911 1.00 33.54  ? 850  LEU A CG  1 
ATOM   4343 C  CD1 . LEU A 1 587 ? -9.285  -63.030 -10.600 1.00 38.20  ? 850  LEU A CD1 1 
ATOM   4344 C  CD2 . LEU A 1 587 ? -7.149  -62.374 -11.641 1.00 34.92  ? 850  LEU A CD2 1 
ATOM   4345 N  N   . ILE A 1 588 ? -8.024  -65.761 -15.816 1.00 29.19  ? 851  ILE A N   1 
ATOM   4346 C  CA  . ILE A 1 588 ? -8.058  -67.075 -16.512 1.00 35.28  ? 851  ILE A CA  1 
ATOM   4347 C  C   . ILE A 1 588 ? -6.728  -67.796 -16.201 1.00 39.63  ? 851  ILE A C   1 
ATOM   4348 O  O   . ILE A 1 588 ? -5.658  -67.161 -16.277 1.00 39.73  ? 851  ILE A O   1 
ATOM   4349 C  CB  . ILE A 1 588 ? -8.416  -66.901 -18.012 1.00 38.55  ? 851  ILE A CB  1 
ATOM   4350 C  CG1 . ILE A 1 588 ? -8.830  -68.217 -18.665 1.00 46.44  ? 851  ILE A CG1 1 
ATOM   4351 C  CG2 . ILE A 1 588 ? -7.332  -66.223 -18.831 1.00 38.85  ? 851  ILE A CG2 1 
ATOM   4352 C  CD1 . ILE A 1 588 ? -10.197 -68.703 -18.273 1.00 46.20  ? 851  ILE A CD1 1 
ATOM   4353 N  N   . GLY A 1 589 ? -6.792  -69.052 -15.755 1.00 42.59  ? 852  GLY A N   1 
ATOM   4354 C  CA  . GLY A 1 589 ? -5.589  -69.829 -15.389 1.00 41.32  ? 852  GLY A CA  1 
ATOM   4355 C  C   . GLY A 1 589 ? -5.459  -69.998 -13.891 1.00 43.04  ? 852  GLY A C   1 
ATOM   4356 O  O   . GLY A 1 589 ? -4.920  -70.993 -13.511 1.00 48.95  ? 852  GLY A O   1 
ATOM   4357 N  N   . LEU A 1 590 ? -5.947  -69.068 -13.064 1.00 39.23  ? 853  LEU A N   1 
ATOM   4358 C  CA  . LEU A 1 590 ? -5.935  -69.226 -11.590 1.00 36.51  ? 853  LEU A CA  1 
ATOM   4359 C  C   . LEU A 1 590 ? -7.001  -70.231 -11.119 1.00 43.14  ? 853  LEU A C   1 
ATOM   4360 O  O   . LEU A 1 590 ? -8.120  -70.390 -11.727 1.00 39.15  ? 853  LEU A O   1 
ATOM   4361 C  CB  . LEU A 1 590 ? -6.138  -67.894 -10.866 1.00 37.60  ? 853  LEU A CB  1 
ATOM   4362 C  CG  . LEU A 1 590 ? -5.166  -66.763 -11.204 1.00 45.53  ? 853  LEU A CG  1 
ATOM   4363 C  CD1 . LEU A 1 590 ? -5.441  -65.557 -10.319 1.00 50.09  ? 853  LEU A CD1 1 
ATOM   4364 C  CD2 . LEU A 1 590 ? -3.719  -67.196 -11.032 1.00 46.74  ? 853  LEU A CD2 1 
ATOM   4365 N  N   . THR A 1 591 ? -6.671  -70.861 -10.007 1.00 44.15  ? 854  THR A N   1 
ATOM   4366 C  CA  . THR A 1 591 ? -7.513  -71.867 -9.332  1.00 44.31  ? 854  THR A CA  1 
ATOM   4367 C  C   . THR A 1 591 ? -8.771  -71.160 -8.840  1.00 37.35  ? 854  THR A C   1 
ATOM   4368 O  O   . THR A 1 591 ? -9.877  -71.706 -9.095  1.00 41.99  ? 854  THR A O   1 
ATOM   4369 C  CB  . THR A 1 591 ? -6.702  -72.590 -8.239  1.00 40.86  ? 854  THR A CB  1 
ATOM   4370 O  OG1 . THR A 1 591 ? -5.678  -73.242 -8.967  1.00 52.20  ? 854  THR A OG1 1 
ATOM   4371 C  CG2 . THR A 1 591 ? -7.455  -73.661 -7.487  1.00 44.26  ? 854  THR A CG2 1 
ATOM   4372 N  N   . SER A 1 592 ? -8.645  -70.008 -8.171  1.00 35.98  ? 855  SER A N   1 
ATOM   4373 C  CA  . SER A 1 592 ? -9.823  -69.247 -7.643  1.00 40.15  ? 855  SER A CA  1 
ATOM   4374 C  C   . SER A 1 592 ? -10.874 -68.950 -8.747  1.00 39.35  ? 855  SER A C   1 
ATOM   4375 O  O   . SER A 1 592 ? -12.100 -69.021 -8.473  1.00 43.03  ? 855  SER A O   1 
ATOM   4376 C  CB  . SER A 1 592 ? -9.405  -67.998 -6.945  1.00 33.79  ? 855  SER A CB  1 
ATOM   4377 O  OG  . SER A 1 592 ? -8.779  -67.133 -7.863  1.00 43.33  ? 855  SER A OG  1 
ATOM   4378 N  N   . ARG A 1 593 ? -10.408 -68.625 -9.956  0.50 38.65  ? 856  ARG A N   1 
ATOM   4379 C  CA  . ARG A 1 593 ? -11.265 -68.287 -11.120 0.50 38.69  ? 856  ARG A CA  1 
ATOM   4380 C  C   . ARG A 1 593 ? -11.929 -69.557 -11.670 0.50 39.07  ? 856  ARG A C   1 
ATOM   4381 O  O   . ARG A 1 593 ? -13.121 -69.487 -12.022 0.50 35.95  ? 856  ARG A O   1 
ATOM   4382 C  CB  . ARG A 1 593 ? -10.440 -67.581 -12.197 0.50 38.26  ? 856  ARG A CB  1 
ATOM   4383 C  CG  . ARG A 1 593 ? -11.277 -66.963 -13.305 0.50 38.78  ? 856  ARG A CG  1 
ATOM   4384 C  CD  . ARG A 1 593 ? -11.513 -67.886 -14.484 0.50 38.29  ? 856  ARG A CD  1 
ATOM   4385 N  NE  . ARG A 1 593 ? -12.056 -67.113 -15.593 0.50 40.45  ? 856  ARG A NE  1 
ATOM   4386 C  CZ  . ARG A 1 593 ? -12.891 -67.580 -16.512 0.50 38.40  ? 856  ARG A CZ  1 
ATOM   4387 N  NH1 . ARG A 1 593 ? -13.271 -68.843 -16.473 0.50 38.59  ? 856  ARG A NH1 1 
ATOM   4388 N  NH2 . ARG A 1 593 ? -13.326 -66.784 -17.476 0.50 36.19  ? 856  ARG A NH2 1 
ATOM   4389 N  N   . ALA A 1 594 ? -11.191 -70.667 -11.761 1.00 35.87  ? 857  ALA A N   1 
ATOM   4390 C  CA  . ALA A 1 594 ? -11.746 -71.946 -12.262 1.00 40.41  ? 857  ALA A CA  1 
ATOM   4391 C  C   . ALA A 1 594 ? -12.838 -72.473 -11.302 1.00 39.49  ? 857  ALA A C   1 
ATOM   4392 O  O   . ALA A 1 594 ? -13.850 -72.975 -11.777 1.00 29.62  ? 857  ALA A O   1 
ATOM   4393 C  CB  . ALA A 1 594 ? -10.637 -72.933 -12.472 1.00 45.74  ? 857  ALA A CB  1 
ATOM   4394 N  N   . THR A 1 595 ? -12.701 -72.276 -10.002 1.00 37.02  ? 858  THR A N   1 
ATOM   4395 C  CA  . THR A 1 595 ? -13.744 -72.639 -9.028  1.00 42.01  ? 858  THR A CA  1 
ATOM   4396 C  C   . THR A 1 595 ? -14.971 -71.750 -9.218  1.00 46.07  ? 858  THR A C   1 
ATOM   4397 O  O   . THR A 1 595 ? -16.126 -72.275 -9.212  1.00 43.40  ? 858  THR A O   1 
ATOM   4398 C  CB  . THR A 1 595 ? -13.283 -72.460 -7.580  1.00 43.65  ? 858  THR A CB  1 
ATOM   4399 O  OG1 . THR A 1 595 ? -12.109 -73.239 -7.414  1.00 48.32  ? 858  THR A OG1 1 
ATOM   4400 C  CG2 . THR A 1 595 ? -14.333 -72.931 -6.597  1.00 44.30  ? 858  THR A CG2 1 
ATOM   4401 N  N   . TRP A 1 596 ? -14.729 -70.446 -9.305  1.00 40.90  ? 859  TRP A N   1 
ATOM   4402 C  CA  . TRP A 1 596 ? -15.792 -69.437 -9.510  1.00 34.10  ? 859  TRP A CA  1 
ATOM   4403 C  C   . TRP A 1 596 ? -16.611 -69.835 -10.741 1.00 33.80  ? 859  TRP A C   1 
ATOM   4404 O  O   . TRP A 1 596 ? -17.876 -69.913 -10.646 1.00 32.39  ? 859  TRP A O   1 
ATOM   4405 C  CB  . TRP A 1 596 ? -15.178 -68.039 -9.638  1.00 35.14  ? 859  TRP A CB  1 
ATOM   4406 C  CG  . TRP A 1 596 ? -16.058 -66.947 -10.152 1.00 31.54  ? 859  TRP A CG  1 
ATOM   4407 C  CD1 . TRP A 1 596 ? -17.101 -66.354 -9.507  1.00 33.00  ? 859  TRP A CD1 1 
ATOM   4408 C  CD2 . TRP A 1 596 ? -15.914 -66.260 -11.395 1.00 31.60  ? 859  TRP A CD2 1 
ATOM   4409 N  NE1 . TRP A 1 596 ? -17.612 -65.330 -10.261 1.00 33.51  ? 859  TRP A NE1 1 
ATOM   4410 C  CE2 . TRP A 1 596 ? -16.893 -65.240 -11.421 1.00 32.01  ? 859  TRP A CE2 1 
ATOM   4411 C  CE3 . TRP A 1 596 ? -15.018 -66.373 -12.459 1.00 33.82  ? 859  TRP A CE3 1 
ATOM   4412 C  CZ2 . TRP A 1 596 ? -17.022 -64.357 -12.488 1.00 32.97  ? 859  TRP A CZ2 1 
ATOM   4413 C  CZ3 . TRP A 1 596 ? -15.130 -65.496 -13.519 1.00 34.06  ? 859  TRP A CZ3 1 
ATOM   4414 C  CH2 . TRP A 1 596 ? -16.150 -64.520 -13.543 1.00 36.60  ? 859  TRP A CH2 1 
ATOM   4415 N  N   . ALA A 1 597 ? -15.939 -70.068 -11.869 0.50 33.41  ? 860  ALA A N   1 
ATOM   4416 C  CA  . ALA A 1 597 ? -16.579 -70.396 -13.166 0.50 36.84  ? 860  ALA A CA  1 
ATOM   4417 C  C   . ALA A 1 597 ? -17.385 -71.698 -13.042 0.50 39.47  ? 860  ALA A C   1 
ATOM   4418 O  O   . ALA A 1 597 ? -18.573 -71.692 -13.401 0.50 39.64  ? 860  ALA A O   1 
ATOM   4419 C  CB  . ALA A 1 597 ? -15.539 -70.488 -14.252 0.50 36.05  ? 860  ALA A CB  1 
ATOM   4420 N  N   . LYS A 1 598 ? -16.762 -72.762 -12.528 1.00 41.04  ? 861  LYS A N   1 
ATOM   4421 C  CA  . LYS A 1 598 ? -17.404 -74.096 -12.398 1.00 40.52  ? 861  LYS A CA  1 
ATOM   4422 C  C   . LYS A 1 598 ? -18.656 -74.005 -11.524 1.00 37.41  ? 861  LYS A C   1 
ATOM   4423 O  O   . LYS A 1 598 ? -19.638 -74.620 -11.889 1.00 36.96  ? 861  LYS A O   1 
ATOM   4424 C  CB  . LYS A 1 598 ? -16.401 -75.078 -11.787 1.00 52.71  ? 861  LYS A CB  1 
ATOM   4425 C  CG  . LYS A 1 598 ? -16.842 -76.532 -11.750 1.00 64.62  ? 861  LYS A CG  1 
ATOM   4426 C  CD  . LYS A 1 598 ? -15.732 -77.491 -11.340 1.00 81.31  ? 861  LYS A CD  1 
ATOM   4427 C  CE  . LYS A 1 598 ? -15.774 -78.798 -12.110 1.00 90.74  ? 861  LYS A CE  1 
ATOM   4428 N  NZ  . LYS A 1 598 ? -17.144 -79.369 -12.170 1.00 91.13  ? 861  LYS A NZ  1 
ATOM   4429 N  N   . ASN A 1 599 ? -18.628 -73.246 -10.424 1.00 39.60  ? 862  ASN A N   1 
ATOM   4430 C  CA  . ASN A 1 599 ? -19.726 -73.199 -9.412  1.00 37.90  ? 862  ASN A CA  1 
ATOM   4431 C  C   . ASN A 1 599 ? -20.571 -71.934 -9.533  1.00 35.86  ? 862  ASN A C   1 
ATOM   4432 O  O   . ASN A 1 599 ? -21.066 -71.474 -8.505  1.00 38.74  ? 862  ASN A O   1 
ATOM   4433 C  CB  . ASN A 1 599 ? -19.186 -73.217 -7.975  1.00 41.56  ? 862  ASN A CB  1 
ATOM   4434 C  CG  . ASN A 1 599 ? -18.416 -74.488 -7.688  1.00 41.49  ? 862  ASN A CG  1 
ATOM   4435 O  OD1 . ASN A 1 599 ? -18.903 -75.564 -7.937  1.00 51.40  ? 862  ASN A OD1 1 
ATOM   4436 N  ND2 . ASN A 1 599 ? -17.218 -74.368 -7.180  1.00 43.81  ? 862  ASN A ND2 1 
ATOM   4437 N  N   . ILE A 1 600 ? -20.703 -71.381 -10.731 1.00 38.01  ? 863  ILE A N   1 
ATOM   4438 C  CA  . ILE A 1 600 ? -21.289 -70.024 -10.947 1.00 34.82  ? 863  ILE A CA  1 
ATOM   4439 C  C   . ILE A 1 600 ? -22.789 -70.044 -10.623 1.00 35.70  ? 863  ILE A C   1 
ATOM   4440 O  O   . ILE A 1 600 ? -23.290 -69.058 -10.073 1.00 33.05  ? 863  ILE A O   1 
ATOM   4441 C  CB  . ILE A 1 600 ? -20.990 -69.504 -12.362 1.00 32.41  ? 863  ILE A CB  1 
ATOM   4442 C  CG1 . ILE A 1 600 ? -21.301 -68.014 -12.475 1.00 38.48  ? 863  ILE A CG1 1 
ATOM   4443 C  CG2 . ILE A 1 600 ? -21.705 -70.304 -13.430 1.00 35.54  ? 863  ILE A CG2 1 
ATOM   4444 C  CD1 . ILE A 1 600 ? -20.437 -67.120 -11.593 1.00 35.39  ? 863  ILE A CD1 1 
ATOM   4445 N  N   A GLN A 1 601 ? -23.469 -71.152 -10.938 0.25 36.16  ? 864  GLN A N   1 
ATOM   4446 N  N   B GLN A 1 601 ? -23.476 -71.149 -10.925 0.25 36.25  ? 864  GLN A N   1 
ATOM   4447 C  CA  A GLN A 1 601 ? -24.925 -71.340 -10.678 0.25 38.64  ? 864  GLN A CA  1 
ATOM   4448 C  CA  B GLN A 1 601 ? -24.940 -71.295 -10.682 0.25 38.80  ? 864  GLN A CA  1 
ATOM   4449 C  C   A GLN A 1 601 ? -25.202 -71.187 -9.175  0.25 35.68  ? 864  GLN A C   1 
ATOM   4450 C  C   B GLN A 1 601 ? -25.220 -71.212 -9.171  0.25 35.76  ? 864  GLN A C   1 
ATOM   4451 O  O   A GLN A 1 601 ? -26.254 -70.647 -8.832  0.25 34.96  ? 864  GLN A O   1 
ATOM   4452 O  O   B GLN A 1 601 ? -26.295 -70.734 -8.813  0.25 35.27  ? 864  GLN A O   1 
ATOM   4453 C  CB  A GLN A 1 601 ? -25.421 -72.693 -11.203 0.25 38.33  ? 864  GLN A CB  1 
ATOM   4454 C  CB  B GLN A 1 601 ? -25.474 -72.581 -11.327 0.25 38.68  ? 864  GLN A CB  1 
ATOM   4455 C  CG  A GLN A 1 601 ? -25.433 -72.792 -12.724 0.25 37.48  ? 864  GLN A CG  1 
ATOM   4456 C  CG  B GLN A 1 601 ? -26.988 -72.740 -11.248 0.25 37.43  ? 864  GLN A CG  1 
ATOM   4457 C  CD  A GLN A 1 601 ? -26.246 -71.705 -13.376 0.25 36.80  ? 864  GLN A CD  1 
ATOM   4458 C  CD  B GLN A 1 601 ? -27.774 -71.575 -11.801 0.25 37.98  ? 864  GLN A CD  1 
ATOM   4459 O  OE1 A GLN A 1 601 ? -27.066 -71.051 -12.740 0.25 40.55  ? 864  GLN A OE1 1 
ATOM   4460 O  OE1 B GLN A 1 601 ? -27.630 -71.189 -12.960 0.25 39.54  ? 864  GLN A OE1 1 
ATOM   4461 N  NE2 A GLN A 1 601 ? -26.031 -71.512 -14.666 0.25 37.20  ? 864  GLN A NE2 1 
ATOM   4462 N  NE2 B GLN A 1 601 ? -28.648 -71.023 -10.974 0.25 35.93  ? 864  GLN A NE2 1 
ATOM   4463 N  N   . THR A 1 602 ? -24.274 -71.614 -8.321  1.00 34.56  ? 865  THR A N   1 
ATOM   4464 C  CA  . THR A 1 602 ? -24.377 -71.428 -6.844  1.00 36.73  ? 865  THR A CA  1 
ATOM   4465 C  C   . THR A 1 602 ? -24.303 -69.943 -6.452  1.00 34.75  ? 865  THR A C   1 
ATOM   4466 O  O   . THR A 1 602 ? -24.986 -69.510 -5.491  1.00 38.33  ? 865  THR A O   1 
ATOM   4467 C  CB  . THR A 1 602 ? -23.255 -72.215 -6.167  1.00 39.09  ? 865  THR A CB  1 
ATOM   4468 O  OG1 . THR A 1 602 ? -23.463 -73.549 -6.636  1.00 40.70  ? 865  THR A OG1 1 
ATOM   4469 C  CG2 . THR A 1 602 ? -23.270 -72.121 -4.665  1.00 41.63  ? 865  THR A CG2 1 
ATOM   4470 N  N   . ALA A 1 603 ? -23.499 -69.144 -7.134  1.00 38.29  ? 866  ALA A N   1 
ATOM   4471 C  CA  . ALA A 1 603 ? -23.402 -67.703 -6.801  1.00 34.76  ? 866  ALA A CA  1 
ATOM   4472 C  C   . ALA A 1 603 ? -24.681 -67.058 -7.275  1.00 29.48  ? 866  ALA A C   1 
ATOM   4473 O  O   . ALA A 1 603 ? -25.232 -66.290 -6.536  1.00 25.07  ? 866  ALA A O   1 
ATOM   4474 C  CB  . ALA A 1 603 ? -22.223 -67.040 -7.438  1.00 35.26  ? 866  ALA A CB  1 
ATOM   4475 N  N   . ILE A 1 604 ? -25.090 -67.361 -8.499  1.00 29.58  ? 867  ILE A N   1 
ATOM   4476 C  CA  . ILE A 1 604 ? -26.364 -66.861 -9.093  1.00 33.71  ? 867  ILE A CA  1 
ATOM   4477 C  C   . ILE A 1 604 ? -27.545 -67.145 -8.138  1.00 30.92  ? 867  ILE A C   1 
ATOM   4478 O  O   . ILE A 1 604 ? -28.289 -66.203 -7.822  1.00 34.66  ? 867  ILE A O   1 
ATOM   4479 C  CB  . ILE A 1 604 ? -26.539 -67.487 -10.490 1.00 35.24  ? 867  ILE A CB  1 
ATOM   4480 C  CG1 . ILE A 1 604 ? -25.503 -66.904 -11.456 1.00 31.22  ? 867  ILE A CG1 1 
ATOM   4481 C  CG2 . ILE A 1 604 ? -27.958 -67.304 -10.996 1.00 35.30  ? 867  ILE A CG2 1 
ATOM   4482 C  CD1 . ILE A 1 604 ? -25.491 -67.553 -12.822 1.00 34.79  ? 867  ILE A CD1 1 
ATOM   4483 N  N   . ASN A 1 605 ? -27.672 -68.379 -7.640  1.00 34.81  ? 868  ASN A N   1 
ATOM   4484 C  CA  . ASN A 1 605 ? -28.743 -68.809 -6.701  1.00 37.29  ? 868  ASN A CA  1 
ATOM   4485 C  C   . ASN A 1 605 ? -28.635 -68.023 -5.385  1.00 33.66  ? 868  ASN A C   1 
ATOM   4486 O  O   . ASN A 1 605 ? -29.668 -67.749 -4.797  1.00 34.80  ? 868  ASN A O   1 
ATOM   4487 C  CB  . ASN A 1 605 ? -28.762 -70.321 -6.468  1.00 42.02  ? 868  ASN A CB  1 
ATOM   4488 C  CG  . ASN A 1 605 ? -29.187 -71.132 -7.680  1.00 50.51  ? 868  ASN A CG  1 
ATOM   4489 O  OD1 . ASN A 1 605 ? -29.896 -70.660 -8.570  1.00 54.83  ? 868  ASN A OD1 1 
ATOM   4490 N  ND2 . ASN A 1 605 ? -28.718 -72.368 -7.746  1.00 57.15  ? 868  ASN A ND2 1 
ATOM   4491 N  N   . GLN A 1 606 ? -27.446 -67.699 -4.902  1.00 37.00  ? 869  GLN A N   1 
ATOM   4492 C  CA  . GLN A 1 606 ? -27.303 -66.935 -3.635  1.00 38.18  ? 869  GLN A CA  1 
ATOM   4493 C  C   . GLN A 1 606 ? -27.981 -65.571 -3.829  1.00 36.20  ? 869  GLN A C   1 
ATOM   4494 O  O   . GLN A 1 606 ? -28.653 -65.091 -2.912  1.00 35.22  ? 869  GLN A O   1 
ATOM   4495 C  CB  . GLN A 1 606 ? -25.837 -66.762 -3.219  1.00 38.10  ? 869  GLN A CB  1 
ATOM   4496 C  CG  . GLN A 1 606 ? -25.680 -66.030 -1.870  1.00 45.36  ? 869  GLN A CG  1 
ATOM   4497 C  CD  . GLN A 1 606 ? -24.268 -65.706 -1.399  1.00 63.58  ? 869  GLN A CD  1 
ATOM   4498 O  OE1 . GLN A 1 606 ? -23.283 -65.693 -2.173  1.00 54.51  ? 869  GLN A OE1 1 
ATOM   4499 N  NE2 . GLN A 1 606 ? -24.163 -65.447 -0.096  1.00 54.38  ? 869  GLN A NE2 1 
ATOM   4500 N  N   . VAL A 1 607 ? -27.748 -64.930 -4.971  1.00 30.22  ? 870  VAL A N   1 
ATOM   4501 C  CA  . VAL A 1 607 ? -28.272 -63.562 -5.206  1.00 31.19  ? 870  VAL A CA  1 
ATOM   4502 C  C   . VAL A 1 607 ? -29.800 -63.710 -5.461  1.00 30.32  ? 870  VAL A C   1 
ATOM   4503 O  O   . VAL A 1 607 ? -30.588 -62.933 -4.870  1.00 29.09  ? 870  VAL A O   1 
ATOM   4504 C  CB  . VAL A 1 607 ? -27.497 -62.883 -6.352  1.00 30.73  ? 870  VAL A CB  1 
ATOM   4505 C  CG1 . VAL A 1 607 ? -28.194 -61.637 -6.832  1.00 28.96  ? 870  VAL A CG1 1 
ATOM   4506 C  CG2 . VAL A 1 607 ? -26.026 -62.624 -5.973  1.00 30.64  ? 870  VAL A CG2 1 
ATOM   4507 N  N   . ARG A 1 608 ? -30.242 -64.722 -6.223  1.00 31.33  ? 871  ARG A N   1 
ATOM   4508 C  CA  . ARG A 1 608 ? -31.701 -64.995 -6.437  1.00 31.39  ? 871  ARG A CA  1 
ATOM   4509 C  C   . ARG A 1 608 ? -32.432 -65.175 -5.094  1.00 34.99  ? 871  ARG A C   1 
ATOM   4510 O  O   . ARG A 1 608 ? -33.493 -64.531 -4.901  1.00 37.85  ? 871  ARG A O   1 
ATOM   4511 C  CB  . ARG A 1 608 ? -31.890 -66.207 -7.333  1.00 28.87  ? 871  ARG A CB  1 
ATOM   4512 C  CG  . ARG A 1 608 ? -31.486 -65.894 -8.766  1.00 29.67  ? 871  ARG A CG  1 
ATOM   4513 C  CD  . ARG A 1 608 ? -31.753 -67.117 -9.586  1.00 30.11  ? 871  ARG A CD  1 
ATOM   4514 N  NE  . ARG A 1 608 ? -31.638 -66.815 -10.992 1.00 34.09  ? 871  ARG A NE  1 
ATOM   4515 C  CZ  . ARG A 1 608 ? -31.596 -67.752 -11.929 1.00 38.82  ? 871  ARG A CZ  1 
ATOM   4516 N  NH1 . ARG A 1 608 ? -31.704 -69.022 -11.571 1.00 43.57  ? 871  ARG A NH1 1 
ATOM   4517 N  NH2 . ARG A 1 608 ? -31.415 -67.433 -13.200 1.00 36.47  ? 871  ARG A NH2 1 
ATOM   4518 N  N   . SER A 1 609 ? -31.862 -65.925 -4.157  1.00 30.44  ? 872  SER A N   1 
ATOM   4519 C  CA  . SER A 1 609 ? -32.457 -66.096 -2.816  1.00 32.91  ? 872  SER A CA  1 
ATOM   4520 C  C   . SER A 1 609 ? -32.575 -64.766 -2.098  1.00 34.70  ? 872  SER A C   1 
ATOM   4521 O  O   . SER A 1 609 ? -33.498 -64.621 -1.311  1.00 34.50  ? 872  SER A O   1 
ATOM   4522 C  CB  . SER A 1 609 ? -31.679 -67.065 -1.989  1.00 34.70  ? 872  SER A CB  1 
ATOM   4523 O  OG  . SER A 1 609 ? -31.555 -68.285 -2.705  1.00 35.51  ? 872  SER A OG  1 
ATOM   4524 N  N   . LEU A 1 610 ? -31.653 -63.846 -2.297  1.00 34.09  ? 873  LEU A N   1 
ATOM   4525 C  CA  . LEU A 1 610 ? -31.658 -62.566 -1.536  1.00 36.24  ? 873  LEU A CA  1 
ATOM   4526 C  C   . LEU A 1 610 ? -32.764 -61.648 -2.073  1.00 34.00  ? 873  LEU A C   1 
ATOM   4527 O  O   . LEU A 1 610 ? -33.479 -61.046 -1.290  1.00 36.64  ? 873  LEU A O   1 
ATOM   4528 C  CB  . LEU A 1 610 ? -30.268 -61.929 -1.652  1.00 36.33  ? 873  LEU A CB  1 
ATOM   4529 C  CG  . LEU A 1 610 ? -29.179 -62.554 -0.785  1.00 38.85  ? 873  LEU A CG  1 
ATOM   4530 C  CD1 . LEU A 1 610 ? -27.834 -61.920 -1.103  1.00 40.29  ? 873  LEU A CD1 1 
ATOM   4531 C  CD2 . LEU A 1 610 ? -29.477 -62.423 0.708   1.00 37.69  ? 873  LEU A CD2 1 
ATOM   4532 N  N   . ILE A 1 611 ? -32.899 -61.585 -3.391  1.00 34.16  ? 874  ILE A N   1 
ATOM   4533 C  CA  . ILE A 1 611 ? -33.863 -60.712 -4.107  1.00 36.90  ? 874  ILE A CA  1 
ATOM   4534 C  C   . ILE A 1 611 ? -35.275 -61.293 -3.920  1.00 39.11  ? 874  ILE A C   1 
ATOM   4535 O  O   . ILE A 1 611 ? -36.203 -60.534 -3.564  1.00 44.36  ? 874  ILE A O   1 
ATOM   4536 C  CB  . ILE A 1 611 ? -33.446 -60.578 -5.585  1.00 38.03  ? 874  ILE A CB  1 
ATOM   4537 C  CG1 . ILE A 1 611 ? -32.104 -59.847 -5.707  1.00 38.28  ? 874  ILE A CG1 1 
ATOM   4538 C  CG2 . ILE A 1 611 ? -34.558 -59.900 -6.359  1.00 40.65  ? 874  ILE A CG2 1 
ATOM   4539 C  CD1 . ILE A 1 611 ? -31.556 -59.663 -7.099  1.00 38.62  ? 874  ILE A CD1 1 
ATOM   4540 N  N   . GLY A 1 612 ? -35.384 -62.612 -4.057  1.00 35.95  ? 875  GLY A N   1 
ATOM   4541 C  CA  . GLY A 1 612 ? -36.548 -63.434 -3.703  1.00 37.20  ? 875  GLY A CA  1 
ATOM   4542 C  C   . GLY A 1 612 ? -37.196 -64.070 -4.930  1.00 39.77  ? 875  GLY A C   1 
ATOM   4543 O  O   . GLY A 1 612 ? -36.530 -64.333 -5.928  1.00 35.23  ? 875  GLY A O   1 
ATOM   4544 N  N   . ASN A 1 613 ? -38.507 -64.277 -4.878  1.00 48.09  ? 876  ASN A N   1 
ATOM   4545 C  CA  . ASN A 1 613 ? -39.231 -65.182 -5.802  1.00 47.65  ? 876  ASN A CA  1 
ATOM   4546 C  C   . ASN A 1 613 ? -39.734 -64.337 -6.971  1.00 43.76  ? 876  ASN A C   1 
ATOM   4547 O  O   . ASN A 1 613 ? -40.839 -63.824 -6.877  1.00 55.05  ? 876  ASN A O   1 
ATOM   4548 C  CB  . ASN A 1 613 ? -40.355 -65.914 -5.057  1.00 55.52  ? 876  ASN A CB  1 
ATOM   4549 C  CG  . ASN A 1 613 ? -41.019 -66.970 -5.908  1.00 63.55  ? 876  ASN A CG  1 
ATOM   4550 O  OD1 . ASN A 1 613 ? -40.478 -67.366 -6.935  1.00 70.78  ? 876  ASN A OD1 1 
ATOM   4551 N  ND2 . ASN A 1 613 ? -42.173 -67.458 -5.476  1.00 63.69  ? 876  ASN A ND2 1 
ATOM   4552 N  N   . GLU A 1 614 ? -38.951 -64.266 -8.042  1.00 34.70  ? 877  GLU A N   1 
ATOM   4553 C  CA  . GLU A 1 614 ? -39.107 -63.333 -9.177  1.00 30.84  ? 877  GLU A CA  1 
ATOM   4554 C  C   . GLU A 1 614 ? -38.940 -64.180 -10.424 1.00 30.94  ? 877  GLU A C   1 
ATOM   4555 O  O   . GLU A 1 614 ? -38.650 -65.410 -10.270 1.00 29.66  ? 877  GLU A O   1 
ATOM   4556 C  CB  . GLU A 1 614 ? -38.089 -62.194 -9.119  1.00 35.72  ? 877  GLU A CB  1 
ATOM   4557 C  CG  . GLU A 1 614 ? -38.219 -61.283 -7.914  1.00 36.27  ? 877  GLU A CG  1 
ATOM   4558 C  CD  . GLU A 1 614 ? -39.377 -60.277 -7.914  1.00 40.85  ? 877  GLU A CD  1 
ATOM   4559 O  OE1 . GLU A 1 614 ? -39.990 -60.034 -8.994  1.00 36.62  ? 877  GLU A OE1 1 
ATOM   4560 O  OE2 . GLU A 1 614 ? -39.626 -59.659 -6.825  1.00 37.84  ? 877  GLU A OE2 1 
ATOM   4561 N  N   . GLU A 1 615 ? -39.189 -63.604 -11.594 1.00 35.58  ? 878  GLU A N   1 
ATOM   4562 C  CA  . GLU A 1 615 ? -38.957 -64.312 -12.880 1.00 41.89  ? 878  GLU A CA  1 
ATOM   4563 C  C   . GLU A 1 615 ? -37.504 -64.035 -13.284 1.00 46.80  ? 878  GLU A C   1 
ATOM   4564 O  O   . GLU A 1 615 ? -37.206 -62.865 -13.564 1.00 45.77  ? 878  GLU A O   1 
ATOM   4565 C  CB  . GLU A 1 615 ? -39.878 -63.822 -13.999 1.00 48.36  ? 878  GLU A CB  1 
ATOM   4566 C  CG  . GLU A 1 615 ? -39.706 -64.602 -15.302 1.00 54.87  ? 878  GLU A CG  1 
ATOM   4567 C  CD  . GLU A 1 615 ? -40.574 -64.088 -16.449 1.00 73.07  ? 878  GLU A CD  1 
ATOM   4568 O  OE1 . GLU A 1 615 ? -41.433 -63.206 -16.196 1.00 72.13  ? 878  GLU A OE1 1 
ATOM   4569 O  OE2 . GLU A 1 615 ? -40.397 -64.558 -17.603 1.00 83.18  ? 878  GLU A OE2 1 
ATOM   4570 N  N   . TYR A 1 616 ? -36.678 -65.082 -13.329 1.00 42.62  ? 879  TYR A N   1 
ATOM   4571 C  CA  . TYR A 1 616 ? -35.255 -65.074 -13.744 1.00 44.47  ? 879  TYR A CA  1 
ATOM   4572 C  C   . TYR A 1 616 ? -35.097 -65.884 -15.039 1.00 47.23  ? 879  TYR A C   1 
ATOM   4573 O  O   . TYR A 1 616 ? -35.852 -66.852 -15.230 1.00 43.91  ? 879  TYR A O   1 
ATOM   4574 C  CB  . TYR A 1 616 ? -34.390 -65.644 -12.617 1.00 38.60  ? 879  TYR A CB  1 
ATOM   4575 C  CG  . TYR A 1 616 ? -34.503 -64.949 -11.277 1.00 36.69  ? 879  TYR A CG  1 
ATOM   4576 C  CD1 . TYR A 1 616 ? -33.783 -63.805 -11.003 1.00 36.03  ? 879  TYR A CD1 1 
ATOM   4577 C  CD2 . TYR A 1 616 ? -35.264 -65.472 -10.248 1.00 34.72  ? 879  TYR A CD2 1 
ATOM   4578 C  CE1 . TYR A 1 616 ? -33.828 -63.193 -9.758  1.00 35.40  ? 879  TYR A CE1 1 
ATOM   4579 C  CE2 . TYR A 1 616 ? -35.312 -64.881 -8.998  1.00 32.49  ? 879  TYR A CE2 1 
ATOM   4580 C  CZ  . TYR A 1 616 ? -34.602 -63.725 -8.748  1.00 35.07  ? 879  TYR A CZ  1 
ATOM   4581 O  OH  . TYR A 1 616 ? -34.644 -63.091 -7.526  1.00 36.50  ? 879  TYR A OH  1 
ATOM   4582 N  N   . THR A 1 617 ? -34.129 -65.499 -15.883 1.00 46.69  ? 880  THR A N   1 
ATOM   4583 C  CA  . THR A 1 617 ? -33.607 -66.279 -17.043 1.00 43.63  ? 880  THR A CA  1 
ATOM   4584 C  C   . THR A 1 617 ? -32.192 -66.812 -16.751 1.00 46.71  ? 880  THR A C   1 
ATOM   4585 O  O   . THR A 1 617 ? -31.381 -66.124 -16.075 1.00 41.14  ? 880  THR A O   1 
ATOM   4586 C  CB  . THR A 1 617 ? -33.549 -65.399 -18.292 1.00 50.29  ? 880  THR A CB  1 
ATOM   4587 O  OG1 . THR A 1 617 ? -34.822 -64.774 -18.354 1.00 43.91  ? 880  THR A OG1 1 
ATOM   4588 C  CG2 . THR A 1 617 ? -33.244 -66.134 -19.582 1.00 50.91  ? 880  THR A CG2 1 
ATOM   4589 N  N   . ASP A 1 618 ? -31.878 -67.980 -17.307 1.00 44.88  ? 881  ASP A N   1 
ATOM   4590 C  CA  . ASP A 1 618 ? -30.500 -68.515 -17.197 1.00 45.75  ? 881  ASP A CA  1 
ATOM   4591 C  C   . ASP A 1 618 ? -29.772 -68.184 -18.503 1.00 48.16  ? 881  ASP A C   1 
ATOM   4592 O  O   . ASP A 1 618 ? -30.124 -68.772 -19.532 1.00 39.98  ? 881  ASP A O   1 
ATOM   4593 C  CB  . ASP A 1 618 ? -30.493 -70.009 -16.878 1.00 50.41  ? 881  ASP A CB  1 
ATOM   4594 C  CG  . ASP A 1 618 ? -29.104 -70.619 -16.828 1.00 57.78  ? 881  ASP A CG  1 
ATOM   4595 O  OD1 . ASP A 1 618 ? -28.153 -69.886 -16.514 1.00 47.14  ? 881  ASP A OD1 1 
ATOM   4596 O  OD2 . ASP A 1 618 ? -28.990 -71.827 -17.100 1.00 63.00  ? 881  ASP A OD2 1 
ATOM   4597 N  N   . TYR A 1 619 ? -28.793 -67.279 -18.442 1.00 43.01  ? 882  TYR A N   1 
ATOM   4598 C  CA  . TYR A 1 619 ? -28.037 -66.860 -19.648 1.00 42.60  ? 882  TYR A CA  1 
ATOM   4599 C  C   . TYR A 1 619 ? -26.720 -67.640 -19.764 1.00 41.85  ? 882  TYR A C   1 
ATOM   4600 O  O   . TYR A 1 619 ? -26.075 -67.545 -20.809 1.00 43.27  ? 882  TYR A O   1 
ATOM   4601 C  CB  . TYR A 1 619 ? -27.799 -65.351 -19.594 1.00 44.06  ? 882  TYR A CB  1 
ATOM   4602 C  CG  . TYR A 1 619 ? -29.019 -64.482 -19.759 1.00 43.22  ? 882  TYR A CG  1 
ATOM   4603 C  CD1 . TYR A 1 619 ? -29.567 -64.254 -21.008 1.00 44.76  ? 882  TYR A CD1 1 
ATOM   4604 C  CD2 . TYR A 1 619 ? -29.609 -63.864 -18.670 1.00 44.23  ? 882  TYR A CD2 1 
ATOM   4605 C  CE1 . TYR A 1 619 ? -30.680 -63.448 -21.172 1.00 46.88  ? 882  TYR A CE1 1 
ATOM   4606 C  CE2 . TYR A 1 619 ? -30.722 -63.054 -18.816 1.00 45.37  ? 882  TYR A CE2 1 
ATOM   4607 C  CZ  . TYR A 1 619 ? -31.259 -62.844 -20.072 1.00 46.56  ? 882  TYR A CZ  1 
ATOM   4608 O  OH  . TYR A 1 619 ? -32.355 -62.050 -20.231 1.00 45.61  ? 882  TYR A OH  1 
ATOM   4609 N  N   . MET A 1 620 ? -26.355 -68.408 -18.738 0.50 45.94  ? 883  MET A N   1 
ATOM   4610 C  CA  . MET A 1 620 ? -25.055 -69.135 -18.742 0.50 52.05  ? 883  MET A CA  1 
ATOM   4611 C  C   . MET A 1 620 ? -24.953 -70.103 -19.936 0.50 56.65  ? 883  MET A C   1 
ATOM   4612 O  O   . MET A 1 620 ? -23.858 -70.184 -20.514 0.50 55.82  ? 883  MET A O   1 
ATOM   4613 C  CB  . MET A 1 620 ? -24.848 -69.904 -17.433 0.50 51.17  ? 883  MET A CB  1 
ATOM   4614 C  CG  . MET A 1 620 ? -24.943 -69.037 -16.189 0.50 52.18  ? 883  MET A CG  1 
ATOM   4615 S  SD  . MET A 1 620 ? -24.138 -67.424 -16.352 0.50 52.04  ? 883  MET A SD  1 
ATOM   4616 C  CE  . MET A 1 620 ? -22.432 -67.919 -16.588 0.50 51.41  ? 883  MET A CE  1 
ATOM   4617 N  N   . PRO A 1 621 ? -26.018 -70.831 -20.342 0.50 61.33  ? 884  PRO A N   1 
ATOM   4618 C  CA  . PRO A 1 621 ? -25.958 -71.716 -21.515 0.50 63.93  ? 884  PRO A CA  1 
ATOM   4619 C  C   . PRO A 1 621 ? -25.596 -70.976 -22.811 0.50 68.57  ? 884  PRO A C   1 
ATOM   4620 O  O   . PRO A 1 621 ? -25.363 -71.639 -23.797 0.50 70.89  ? 884  PRO A O   1 
ATOM   4621 C  CB  . PRO A 1 621 ? -27.374 -72.297 -21.609 0.50 64.38  ? 884  PRO A CB  1 
ATOM   4622 C  CG  . PRO A 1 621 ? -27.903 -72.199 -20.200 0.50 62.98  ? 884  PRO A CG  1 
ATOM   4623 C  CD  . PRO A 1 621 ? -27.320 -70.905 -19.677 0.50 63.05  ? 884  PRO A CD  1 
ATOM   4624 N  N   . SER A 1 622 ? -25.576 -69.642 -22.788 0.50 77.91  ? 885  SER A N   1 
ATOM   4625 C  CA  . SER A 1 622 ? -25.126 -68.861 -23.970 0.50 84.65  ? 885  SER A CA  1 
ATOM   4626 C  C   . SER A 1 622 ? -23.628 -69.098 -24.159 0.50 90.68  ? 885  SER A C   1 
ATOM   4627 O  O   . SER A 1 622 ? -23.117 -68.815 -25.256 0.50 90.99  ? 885  SER A O   1 
ATOM   4628 C  CB  . SER A 1 622 ? -25.420 -67.398 -23.799 0.50 83.49  ? 885  SER A CB  1 
ATOM   4629 O  OG  . SER A 1 622 ? -24.556 -66.817 -22.836 0.50 82.79  ? 885  SER A OG  1 
ATOM   4630 N  N   . MET A 1 623 ? -22.959 -69.579 -23.110 0.50 95.44  ? 886  MET A N   1 
ATOM   4631 C  CA  . MET A 1 623 ? -21.510 -69.885 -23.193 0.50 104.01 ? 886  MET A CA  1 
ATOM   4632 C  C   . MET A 1 623 ? -21.345 -71.385 -23.450 0.50 112.55 ? 886  MET A C   1 
ATOM   4633 O  O   . MET A 1 623 ? -22.012 -72.174 -22.760 0.50 115.59 ? 886  MET A O   1 
ATOM   4634 C  CB  . MET A 1 623 ? -20.798 -69.488 -21.897 0.50 104.92 ? 886  MET A CB  1 
ATOM   4635 C  CG  . MET A 1 623 ? -21.279 -68.168 -21.331 0.50 103.96 ? 886  MET A CG  1 
ATOM   4636 S  SD  . MET A 1 623 ? -20.226 -67.567 -19.991 0.50 99.31  ? 886  MET A SD  1 
ATOM   4637 C  CE  . MET A 1 623 ? -18.881 -66.849 -20.931 0.50 98.23  ? 886  MET A CE  1 
ATOM   4638 N  N   . LYS A 1 624 ? -20.486 -71.756 -24.400 0.50 122.07 ? 887  LYS A N   1 
ATOM   4639 C  CA  . LYS A 1 624 ? -20.331 -73.182 -24.792 0.50 129.85 ? 887  LYS A CA  1 
ATOM   4640 C  C   . LYS A 1 624 ? -20.078 -74.073 -23.578 0.50 135.57 ? 887  LYS A C   1 
ATOM   4641 O  O   . LYS A 1 624 ? -20.669 -75.167 -23.524 0.50 138.62 ? 887  LYS A O   1 
ATOM   4642 C  CB  . LYS A 1 624 ? -19.168 -73.327 -25.775 0.50 134.58 ? 887  LYS A CB  1 
ATOM   4643 C  CG  . LYS A 1 624 ? -18.988 -74.714 -26.373 0.50 138.66 ? 887  LYS A CG  1 
ATOM   4644 C  CD  . LYS A 1 624 ? -18.061 -74.725 -27.568 0.50 142.76 ? 887  LYS A CD  1 
ATOM   4645 C  CE  . LYS A 1 624 ? -16.598 -74.751 -27.181 0.50 144.78 ? 887  LYS A CE  1 
ATOM   4646 N  NZ  . LYS A 1 624 ? -15.990 -73.401 -27.240 0.50 145.85 ? 887  LYS A NZ  1 
ATOM   4647 N  N   . ARG A 1 625 ? -19.250 -73.626 -22.636 0.50 140.15 ? 888  ARG A N   1 
ATOM   4648 C  CA  . ARG A 1 625 ? -18.874 -74.541 -21.521 0.50 144.71 ? 888  ARG A CA  1 
ATOM   4649 C  C   . ARG A 1 625 ? -20.108 -74.888 -20.678 0.50 145.73 ? 888  ARG A C   1 
ATOM   4650 O  O   . ARG A 1 625 ? -20.194 -76.045 -20.214 0.50 141.86 ? 888  ARG A O   1 
ATOM   4651 C  CB  . ARG A 1 625 ? -17.769 -73.926 -20.654 0.50 148.40 ? 888  ARG A CB  1 
ATOM   4652 C  CG  . ARG A 1 625 ? -18.199 -72.712 -19.843 0.50 151.03 ? 888  ARG A CG  1 
ATOM   4653 C  CD  . ARG A 1 625 ? -17.189 -72.367 -18.763 0.50 150.16 ? 888  ARG A CD  1 
ATOM   4654 N  NE  . ARG A 1 625 ? -17.291 -73.249 -17.608 0.50 149.59 ? 888  ARG A NE  1 
ATOM   4655 C  CZ  . ARG A 1 625 ? -16.341 -73.408 -16.694 0.50 148.14 ? 888  ARG A CZ  1 
ATOM   4656 N  NH1 . ARG A 1 625 ? -15.199 -72.750 -16.802 0.50 148.74 ? 888  ARG A NH1 1 
ATOM   4657 N  NH2 . ARG A 1 625 ? -16.533 -74.231 -15.678 0.50 144.39 ? 888  ARG A NH2 1 
ATOM   4658 N  N   . PHE A 1 626 ? -21.022 -73.930 -20.486 0.50 148.65 ? 889  PHE A N   1 
ATOM   4659 C  CA  . PHE A 1 626 ? -22.244 -74.073 -19.650 0.50 152.26 ? 889  PHE A CA  1 
ATOM   4660 C  C   . PHE A 1 626 ? -23.366 -74.711 -20.477 0.50 162.68 ? 889  PHE A C   1 
ATOM   4661 O  O   . PHE A 1 626 ? -24.321 -75.252 -19.884 0.50 165.03 ? 889  PHE A O   1 
ATOM   4662 C  CB  . PHE A 1 626 ? -22.677 -72.718 -19.086 0.50 147.72 ? 889  PHE A CB  1 
ATOM   4663 C  CG  . PHE A 1 626 ? -21.658 -72.058 -18.192 0.50 145.59 ? 889  PHE A CG  1 
ATOM   4664 C  CD1 . PHE A 1 626 ? -21.291 -72.636 -16.988 0.50 145.55 ? 889  PHE A CD1 1 
ATOM   4665 C  CD2 . PHE A 1 626 ? -21.069 -70.858 -18.554 0.50 145.96 ? 889  PHE A CD2 1 
ATOM   4666 C  CE1 . PHE A 1 626 ? -20.352 -72.030 -16.168 0.50 146.75 ? 889  PHE A CE1 1 
ATOM   4667 C  CE2 . PHE A 1 626 ? -20.131 -70.252 -17.733 0.50 146.39 ? 889  PHE A CE2 1 
ATOM   4668 C  CZ  . PHE A 1 626 ? -19.774 -70.839 -16.542 0.50 146.69 ? 889  PHE A CZ  1 
ATOM   4669 N  N   . ARG A 1 627 ? -23.251 -74.647 -21.806 0.50 175.44 ? 890  ARG A N   1 
ATOM   4670 C  CA  . ARG A 1 627 ? -24.247 -75.205 -22.759 0.50 183.77 ? 890  ARG A CA  1 
ATOM   4671 C  C   . ARG A 1 627 ? -24.284 -76.730 -22.595 0.50 187.97 ? 890  ARG A C   1 
ATOM   4672 O  O   . ARG A 1 627 ? -24.280 -77.437 -23.622 0.50 199.46 ? 890  ARG A O   1 
ATOM   4673 C  CB  . ARG A 1 627 ? -23.902 -74.784 -24.193 0.50 185.67 ? 890  ARG A CB  1 
ATOM   4674 C  CG  . ARG A 1 627 ? -24.959 -75.150 -25.226 0.50 186.85 ? 890  ARG A CG  1 
ATOM   4675 C  CD  . ARG A 1 627 ? -24.782 -74.409 -26.540 0.50 187.39 ? 890  ARG A CD  1 
ATOM   4676 N  NE  . ARG A 1 627 ? -23.400 -74.406 -26.998 0.50 189.82 ? 890  ARG A NE  1 
ATOM   4677 C  CZ  . ARG A 1 627 ? -22.860 -75.340 -27.774 0.50 191.52 ? 890  ARG A CZ  1 
ATOM   4678 N  NH1 . ARG A 1 627 ? -23.589 -76.362 -28.186 0.50 190.75 ? 890  ARG A NH1 1 
ATOM   4679 N  NH2 . ARG A 1 627 ? -21.592 -75.250 -28.134 0.50 191.80 ? 890  ARG A NH2 1 
ATOM   4680 N  N   . ARG A 1 628 ? -24.319 -77.207 -21.346 0.50 183.37 ? 891  ARG A N   1 
ATOM   4681 C  CA  . ARG A 1 628 ? -24.333 -78.652 -20.988 0.50 181.56 ? 891  ARG A CA  1 
ATOM   4682 C  C   . ARG A 1 628 ? -22.903 -79.201 -21.041 0.50 181.61 ? 891  ARG A C   1 
ATOM   4683 O  O   . ARG A 1 628 ? -22.583 -80.049 -21.875 0.50 178.95 ? 891  ARG A O   1 
ATOM   4684 C  CB  . ARG A 1 628 ? -25.252 -79.429 -21.936 0.50 181.71 ? 891  ARG A CB  1 
ATOM   4685 C  CG  . ARG A 1 628 ? -26.717 -79.026 -21.847 0.50 182.27 ? 891  ARG A CG  1 
ATOM   4686 C  CD  . ARG A 1 628 ? -27.214 -79.043 -20.415 0.50 184.90 ? 891  ARG A CD  1 
ATOM   4687 N  NE  . ARG A 1 628 ? -26.992 -80.335 -19.783 0.50 190.54 ? 891  ARG A NE  1 
ATOM   4688 C  CZ  . ARG A 1 628 ? -27.182 -80.585 -18.492 0.50 194.62 ? 891  ARG A CZ  1 
ATOM   4689 N  NH1 . ARG A 1 628 ? -27.599 -79.625 -17.686 0.50 195.69 ? 891  ARG A NH1 1 
ATOM   4690 N  NH2 . ARG A 1 628 ? -26.952 -81.794 -18.012 0.50 196.31 ? 891  ARG A NH2 1 
HETATM 4691 ZN ZN  . ZN  B 2 .   ? -6.488  -54.849 -23.639 1.00 30.16  2 1001 ZN  A ZN  1 
HETATM 4692 ZN ZN  . ZN  C 2 .   ? -26.039 -14.247 -12.693 1.00 60.21  2 1002 ZN  A ZN  1 
HETATM 4693 O  O1  A MES D 3 .   ? -28.525 -56.997 0.413   0.25 774.79 ? 1003 MES A O1  1 
HETATM 4694 O  O1  B MES D 3 .   ? -28.197 -56.808 0.248   0.25 43.56  ? 1003 MES A O1  1 
HETATM 4695 C  C2  A MES D 3 .   ? -27.917 -57.360 1.642   0.25 779.62 ? 1003 MES A C2  1 
HETATM 4696 C  C2  B MES D 3 .   ? -27.557 -57.477 1.328   0.25 41.50  ? 1003 MES A C2  1 
HETATM 4697 C  C3  A MES D 3 .   ? -26.458 -56.979 1.674   0.25 781.65 ? 1003 MES A C3  1 
HETATM 4698 C  C3  B MES D 3 .   ? -26.059 -57.562 1.136   0.25 39.53  ? 1003 MES A C3  1 
HETATM 4699 N  N4  A MES D 3 .   ? -25.727 -57.611 0.531   0.25 782.27 ? 1003 MES A N4  1 
HETATM 4700 N  N4  B MES D 3 .   ? -25.743 -58.239 -0.159  0.25 37.11  ? 1003 MES A N4  1 
HETATM 4701 C  C5  A MES D 3 .   ? -26.428 -57.284 -0.750  0.25 777.14 ? 1003 MES A C5  1 
HETATM 4702 C  C5  B MES D 3 .   ? -26.409 -57.467 -1.248  0.25 39.90  ? 1003 MES A C5  1 
HETATM 4703 C  C6  A MES D 3 .   ? -27.883 -57.668 -0.659  0.25 771.74 ? 1003 MES A C6  1 
HETATM 4704 C  C6  B MES D 3 .   ? -27.895 -57.432 -0.994  0.25 41.96  ? 1003 MES A C6  1 
HETATM 4705 C  C7  A MES D 3 .   ? -24.290 -57.181 0.496   0.25 782.29 ? 1003 MES A C7  1 
HETATM 4706 C  C7  B MES D 3 .   ? -24.266 -58.424 -0.409  0.25 35.83  ? 1003 MES A C7  1 
HETATM 4707 C  C8  A MES D 3 .   ? -23.385 -58.178 -0.201  0.25 781.68 ? 1003 MES A C8  1 
HETATM 4708 C  C8  B MES D 3 .   ? -23.375 -57.430 0.320   0.25 32.67  ? 1003 MES A C8  1 
HETATM 4709 S  S   A MES D 3 .   ? -21.663 -57.754 -0.010  0.25 792.31 ? 1003 MES A S   1 
HETATM 4710 S  S   B MES D 3 .   ? -21.630 -57.845 0.255   0.25 32.81  ? 1003 MES A S   1 
HETATM 4711 O  O1S A MES D 3 .   ? -21.118 -58.669 0.929   0.25 797.45 ? 1003 MES A O1S 1 
HETATM 4712 O  O1S B MES D 3 .   ? -21.547 -59.282 0.312   0.25 29.05  ? 1003 MES A O1S 1 
HETATM 4713 O  O2S A MES D 3 .   ? -21.087 -57.934 -1.342  0.25 767.38 ? 1003 MES A O2S 1 
HETATM 4714 O  O2S B MES D 3 .   ? -21.159 -57.333 -1.003  0.25 27.91  ? 1003 MES A O2S 1 
HETATM 4715 O  O3S A MES D 3 .   ? -21.625 -56.392 0.402   0.25 797.02 ? 1003 MES A O3S 1 
HETATM 4716 O  O3S B MES D 3 .   ? -21.062 -57.185 1.395   0.25 27.65  ? 1003 MES A O3S 1 
HETATM 4717 S  S   . DMS E 4 .   ? -26.877 -61.495 -20.941 1.00 57.17  ? 1004 DMS A S   1 
HETATM 4718 O  O   . DMS E 4 .   ? -26.804 -62.141 -22.340 1.00 49.39  ? 1004 DMS A O   1 
HETATM 4719 C  C1  . DMS E 4 .   ? -28.077 -60.188 -21.084 1.00 64.52  ? 1004 DMS A C1  1 
HETATM 4720 C  C2  . DMS E 4 .   ? -25.452 -60.434 -20.872 1.00 58.51  ? 1004 DMS A C2  1 
HETATM 4721 S  S   . DMS F 4 .   ? -16.131 -69.005 -28.790 1.00 102.52 ? 1005 DMS A S   1 
HETATM 4722 O  O   . DMS F 4 .   ? -16.423 -67.551 -29.024 1.00 85.87  ? 1005 DMS A O   1 
HETATM 4723 C  C1  . DMS F 4 .   ? -17.174 -69.514 -27.445 1.00 101.02 ? 1005 DMS A C1  1 
HETATM 4724 C  C2  . DMS F 4 .   ? -14.567 -69.079 -27.950 1.00 96.38  ? 1005 DMS A C2  1 
HETATM 4725 S  S   . DMS G 4 .   ? -23.014 -47.511 -16.216 1.00 65.39  ? 1006 DMS A S   1 
HETATM 4726 O  O   . DMS G 4 .   ? -24.192 -47.186 -17.090 1.00 67.10  ? 1006 DMS A O   1 
HETATM 4727 C  C1  . DMS G 4 .   ? -21.608 -47.195 -17.242 1.00 61.94  ? 1006 DMS A C1  1 
HETATM 4728 C  C2  . DMS G 4 .   ? -22.906 -49.262 -16.260 1.00 58.55  ? 1006 DMS A C2  1 
HETATM 4729 P  P   . PO4 H 5 .   ? -3.806  -39.121 -23.672 1.00 81.94  ? 1007 PO4 A P   1 
HETATM 4730 O  O1  . PO4 H 5 .   ? -2.437  -39.819 -23.095 1.00 50.38  ? 1007 PO4 A O1  1 
HETATM 4731 O  O2  . PO4 H 5 .   ? -3.492  -37.730 -24.423 1.00 46.66  ? 1007 PO4 A O2  1 
HETATM 4732 O  O3  . PO4 H 5 .   ? -4.622  -40.090 -24.656 1.00 42.89  ? 1007 PO4 A O3  1 
HETATM 4733 O  O4  . PO4 H 5 .   ? -4.645  -38.820 -22.464 1.00 55.29  ? 1007 PO4 A O4  1 
HETATM 4734 P  P   . PO4 I 5 .   ? -17.913 -9.323  -28.249 1.00 115.98 ? 1008 PO4 A P   1 
HETATM 4735 O  O1  . PO4 I 5 .   ? -17.600 -9.582  -26.755 1.00 83.78  ? 1008 PO4 A O1  1 
HETATM 4736 O  O2  . PO4 I 5 .   ? -16.612 -9.238  -29.052 1.00 101.94 ? 1008 PO4 A O2  1 
HETATM 4737 O  O3  . PO4 I 5 .   ? -18.792 -10.468 -28.802 1.00 92.17  ? 1008 PO4 A O3  1 
HETATM 4738 O  O4  . PO4 I 5 .   ? -18.656 -7.992  -28.387 1.00 96.67  ? 1008 PO4 A O4  1 
HETATM 4739 C  C1  . PEG J 6 .   ? -16.274 -42.966 -41.100 1.00 74.29  ? 1009 PEG A C1  1 
HETATM 4740 O  O1  . PEG J 6 .   ? -17.617 -43.094 -40.673 1.00 70.30  ? 1009 PEG A O1  1 
HETATM 4741 C  C2  . PEG J 6 .   ? -16.036 -43.664 -42.397 1.00 77.98  ? 1009 PEG A C2  1 
HETATM 4742 O  O2  . PEG J 6 .   ? -16.269 -45.061 -42.230 1.00 80.47  ? 1009 PEG A O2  1 
HETATM 4743 C  C3  . PEG J 6 .   ? -16.292 -45.787 -43.458 1.00 80.67  ? 1009 PEG A C3  1 
HETATM 4744 C  C4  . PEG J 6 .   ? -14.969 -46.438 -43.697 1.00 86.22  ? 1009 PEG A C4  1 
HETATM 4745 O  O4  . PEG J 6 .   ? -15.099 -47.806 -44.037 1.00 87.94  ? 1009 PEG A O4  1 
HETATM 4746 N  N1  . K6U K 7 .   ? -20.599 -31.242 -18.389 0.26 57.85  ? 1010 K6U A N1  1 
HETATM 4747 C  C4  . K6U K 7 .   ? -24.441 -32.544 -21.526 0.26 52.74  ? 1010 K6U A C4  1 
HETATM 4748 C  C5  . K6U K 7 .   ? -24.450 -31.940 -20.291 0.26 53.60  ? 1010 K6U A C5  1 
HETATM 4749 C  C6  . K6U K 7 .   ? -23.262 -31.560 -19.691 0.26 54.51  ? 1010 K6U A C6  1 
HETATM 4750 C  C7  . K6U K 7 .   ? -22.044 -31.786 -20.329 0.26 54.93  ? 1010 K6U A C7  1 
HETATM 4751 C  C8  . K6U K 7 .   ? -20.812 -31.369 -19.654 0.26 57.56  ? 1010 K6U A C8  1 
HETATM 4752 C  C1  . K6U K 7 .   ? -20.753 -32.512 -23.578 0.26 52.73  ? 1010 K6U A C1  1 
HETATM 4753 C  C2  . K6U K 7 .   ? -22.053 -32.403 -21.583 0.26 54.14  ? 1010 K6U A C2  1 
HETATM 4754 C  C3  . K6U K 7 .   ? -23.245 -32.779 -22.180 0.26 52.74  ? 1010 K6U A C3  1 
HETATM 4755 C  C9  . K6U K 7 .   ? -18.790 -30.673 -19.482 0.26 56.96  ? 1010 K6U A C9  1 
HETATM 4756 N  N2  . K6U K 7 .   ? -19.293 -30.789 -18.257 0.26 56.62  ? 1010 K6U A N2  1 
HETATM 4757 O  O1  . K6U K 7 .   ? -20.833 -32.610 -22.159 0.26 53.94  ? 1010 K6U A O1  1 
HETATM 4758 O  O2  . K6U K 7 .   ? -19.720 -31.033 -20.400 0.26 58.21  ? 1010 K6U A O2  1 
HETATM 4759 N  N1  . K6U L 7 .   ? -19.340 -28.646 -14.346 0.26 40.12  ? 1011 K6U A N1  1 
HETATM 4760 C  C4  . K6U L 7 .   ? -24.272 -29.885 -14.888 0.26 42.47  ? 1011 K6U A C4  1 
HETATM 4761 C  C5  . K6U L 7 .   ? -23.649 -28.753 -14.422 0.26 42.01  ? 1011 K6U A C5  1 
HETATM 4762 C  C6  . K6U L 7 .   ? -22.268 -28.665 -14.420 0.26 41.90  ? 1011 K6U A C6  1 
HETATM 4763 C  C7  . K6U L 7 .   ? -21.494 -29.723 -14.894 0.26 42.06  ? 1011 K6U A C7  1 
HETATM 4764 C  C8  . K6U L 7 .   ? -20.039 -29.584 -14.883 0.26 40.65  ? 1011 K6U A C8  1 
HETATM 4765 C  C1  . K6U L 7 .   ? -21.191 -33.018 -15.026 0.26 46.86  ? 1011 K6U A C1  1 
HETATM 4766 C  C2  . K6U L 7 .   ? -22.144 -30.866 -15.364 0.26 43.93  ? 1011 K6U A C2  1 
HETATM 4767 C  C3  . K6U L 7 .   ? -23.526 -30.950 -15.359 0.26 43.74  ? 1011 K6U A C3  1 
HETATM 4768 C  C9  . K6U L 7 .   ? -17.991 -30.081 -15.319 0.26 39.99  ? 1011 K6U A C9  1 
HETATM 4769 N  N2  . K6U L 7 .   ? -18.011 -28.945 -14.616 0.26 39.99  ? 1011 K6U A N2  1 
HETATM 4770 O  O1  . K6U L 7 .   ? -21.334 -31.859 -15.833 0.26 46.51  ? 1011 K6U A O1  1 
HETATM 4771 O  O2  . K6U L 7 .   ? -19.261 -30.517 -15.507 0.26 40.42  ? 1011 K6U A O2  1 
HETATM 4772 CL CL  . CL  M 8 .   ? 4.379   -48.425 -29.728 1.00 50.44  ? 1012 CL  A CL  1 
HETATM 4773 O  O   . HOH N 9 .   ? -32.765 -51.605 -26.744 1.00 51.35  ? 1101 HOH A O   1 
HETATM 4774 O  O   . HOH N 9 .   ? -22.197 -43.542 -31.416 1.00 49.93  ? 1102 HOH A O   1 
HETATM 4775 O  O   . HOH N 9 .   ? -3.677  -54.412 -36.289 1.00 63.97  ? 1103 HOH A O   1 
HETATM 4776 O  O   . HOH N 9 .   ? -28.625 -69.335 -14.024 1.00 53.92  ? 1104 HOH A O   1 
HETATM 4777 O  O   . HOH N 9 .   ? -40.371 -57.437 -6.414  1.00 66.00  ? 1105 HOH A O   1 
HETATM 4778 O  O   . HOH N 9 .   ? -2.865  -48.337 -39.770 1.00 53.12  ? 1106 HOH A O   1 
HETATM 4779 O  O   . HOH N 9 .   ? -20.338 -29.860 -26.173 0.26 24.21  ? 1107 HOH A O   1 
HETATM 4780 O  O   . HOH N 9 .   ? -19.890 -29.496 -22.241 0.26 13.97  ? 1108 HOH A O   1 
HETATM 4781 O  O   . HOH N 9 .   ? -13.708 -73.868 -14.027 1.00 46.33  ? 1109 HOH A O   1 
HETATM 4782 O  O   . HOH N 9 .   ? -21.619 -48.956 -34.751 1.00 55.87  ? 1110 HOH A O   1 
HETATM 4783 O  O   . HOH N 9 .   ? -32.790 -62.917 -15.005 1.00 32.39  ? 1111 HOH A O   1 
HETATM 4784 O  O   . HOH N 9 .   ? -5.621  -59.745 -0.750  1.00 44.01  ? 1112 HOH A O   1 
HETATM 4785 O  O   . HOH N 9 .   ? -31.787 -56.943 -21.805 1.00 38.45  ? 1113 HOH A O   1 
HETATM 4786 O  O   . HOH N 9 .   ? -15.905 -11.609 -29.277 1.00 49.99  ? 1114 HOH A O   1 
HETATM 4787 O  O   . HOH N 9 .   ? -7.503  -48.492 0.864   1.00 56.65  ? 1115 HOH A O   1 
HETATM 4788 O  O   . HOH N 9 .   ? -13.077 -11.018 -10.405 0.26 46.60  ? 1116 HOH A O   1 
HETATM 4789 O  O   . HOH N 9 .   ? -23.190 -64.841 -38.293 0.50 40.14  ? 1117 HOH A O   1 
HETATM 4790 O  O   . HOH N 9 .   ? -4.585  -53.945 -11.840 1.00 60.47  ? 1118 HOH A O   1 
HETATM 4791 O  O   . HOH N 9 .   ? -14.637 -70.662 -18.073 0.50 54.67  ? 1119 HOH A O   1 
HETATM 4792 O  O   . HOH N 9 .   ? -13.090 -12.511 -26.439 1.00 54.09  ? 1120 HOH A O   1 
HETATM 4793 O  O   . HOH N 9 .   ? -14.812 -63.567 -0.594  1.00 38.76  ? 1121 HOH A O   1 
HETATM 4794 O  O   . HOH N 9 .   ? -2.873  -60.073 -31.457 1.00 62.12  ? 1122 HOH A O   1 
HETATM 4795 O  O   . HOH N 9 .   ? -6.621  -19.831 -26.275 1.00 47.26  ? 1123 HOH A O   1 
HETATM 4796 O  O   . HOH N 9 .   ? -34.521 -20.027 -23.489 1.00 48.54  ? 1124 HOH A O   1 
HETATM 4797 O  O   . HOH N 9 .   ? -20.893 -46.840 -10.254 1.00 53.28  ? 1125 HOH A O   1 
HETATM 4798 O  O   . HOH N 9 .   ? -4.813  -15.076 -27.575 1.00 49.61  ? 1126 HOH A O   1 
HETATM 4799 O  O   . HOH N 9 .   ? -12.427 -57.752 -0.000  0.50 26.78  ? 1127 HOH A O   1 
HETATM 4800 O  O   . HOH N 9 .   ? -7.634  -42.461 -42.657 1.00 57.50  ? 1128 HOH A O   1 
HETATM 4801 O  O   . HOH N 9 .   ? -12.571 -42.042 -38.788 1.00 42.98  ? 1129 HOH A O   1 
HETATM 4802 O  O   . HOH N 9 .   ? -22.557 -65.413 -23.677 1.00 44.03  ? 1130 HOH A O   1 
HETATM 4803 O  O   . HOH N 9 .   ? -40.234 -60.938 -11.408 1.00 34.67  ? 1131 HOH A O   1 
HETATM 4804 O  O   . HOH N 9 .   ? -22.121 -9.797  -8.946  1.00 55.25  ? 1132 HOH A O   1 
HETATM 4805 O  O   . HOH N 9 .   ? -16.979 -34.226 -41.939 1.00 63.45  ? 1133 HOH A O   1 
HETATM 4806 O  O   . HOH N 9 .   ? -13.820 -49.279 -31.944 1.00 39.99  ? 1134 HOH A O   1 
HETATM 4807 O  O   . HOH N 9 .   ? 1.827   -31.959 -38.607 1.00 35.14  ? 1135 HOH A O   1 
HETATM 4808 O  O   . HOH N 9 .   ? -8.839  -63.439 -30.827 0.50 39.89  ? 1136 HOH A O   1 
HETATM 4809 O  O   . HOH N 9 .   ? -39.310 -63.419 -19.698 1.00 69.51  ? 1137 HOH A O   1 
HETATM 4810 O  O   . HOH N 9 .   ? 11.513  -34.306 -32.714 1.00 37.81  ? 1138 HOH A O   1 
HETATM 4811 O  O   . HOH N 9 .   ? -25.031 -13.926 -4.339  1.00 56.48  ? 1139 HOH A O   1 
HETATM 4812 O  O   . HOH N 9 .   ? 0.310   -32.366 -27.437 1.00 34.81  ? 1140 HOH A O   1 
HETATM 4813 O  O   . HOH N 9 .   ? -3.032  -54.860 -17.947 1.00 33.27  ? 1141 HOH A O   1 
HETATM 4814 O  O   . HOH N 9 .   ? 1.179   -41.497 -24.368 1.00 54.42  ? 1142 HOH A O   1 
HETATM 4815 O  O   . HOH N 9 .   ? -26.585 -25.371 -32.967 1.00 36.12  ? 1143 HOH A O   1 
HETATM 4816 O  O   . HOH N 9 .   ? -22.342 -50.621 -9.201  1.00 39.52  ? 1144 HOH A O   1 
HETATM 4817 O  O   . HOH N 9 .   ? 0.213   -54.685 -33.196 1.00 58.38  ? 1145 HOH A O   1 
HETATM 4818 O  O   . HOH N 9 .   ? -32.350 -59.813 -18.809 1.00 45.67  ? 1146 HOH A O   1 
HETATM 4819 O  O   . HOH N 9 .   ? -15.125 -53.668 -39.670 1.00 45.09  ? 1147 HOH A O   1 
HETATM 4820 O  O   . HOH N 9 .   ? -19.363 -26.881 -39.431 1.00 42.65  ? 1148 HOH A O   1 
HETATM 4821 O  O   . HOH N 9 .   ? -35.720 -65.893 -0.609  1.00 47.97  ? 1149 HOH A O   1 
HETATM 4822 O  O   . HOH N 9 .   ? -4.758  -53.521 -28.200 0.50 68.09  ? 1150 HOH A O   1 
HETATM 4823 O  O   . HOH N 9 .   ? 5.905   -32.296 -37.479 1.00 42.21  ? 1151 HOH A O   1 
HETATM 4824 O  O   . HOH N 9 .   ? 10.549  -26.465 -29.082 1.00 45.50  ? 1152 HOH A O   1 
HETATM 4825 O  O   . HOH N 9 .   ? -38.146 -67.142 -8.315  1.00 48.48  ? 1153 HOH A O   1 
HETATM 4826 O  O   . HOH N 9 .   ? -3.750  -61.179 -15.274 1.00 34.94  ? 1154 HOH A O   1 
HETATM 4827 O  O   . HOH N 9 .   ? -2.599  -57.536 -27.342 1.00 34.46  ? 1155 HOH A O   1 
HETATM 4828 O  O   . HOH N 9 .   ? 0.144   -30.950 -22.715 1.00 36.07  ? 1156 HOH A O   1 
HETATM 4829 O  O   . HOH N 9 .   ? -22.902 -20.637 -37.351 1.00 49.28  ? 1157 HOH A O   1 
HETATM 4830 O  O   . HOH N 9 .   ? 6.703   -34.603 -43.424 1.00 58.11  ? 1158 HOH A O   1 
HETATM 4831 O  O   . HOH N 9 .   ? 1.480   -17.492 -47.084 1.00 55.89  ? 1159 HOH A O   1 
HETATM 4832 O  O   . HOH N 9 .   ? 2.850   -38.948 -26.631 1.00 32.69  ? 1160 HOH A O   1 
HETATM 4833 O  O   . HOH N 9 .   ? -32.787 -48.434 -18.849 1.00 51.87  ? 1161 HOH A O   1 
HETATM 4834 O  O   . HOH N 9 .   ? -8.776  -25.754 -43.965 1.00 45.74  ? 1162 HOH A O   1 
HETATM 4835 O  O   . HOH N 9 .   ? -18.150 -61.785 -2.980  1.00 30.22  ? 1163 HOH A O   1 
HETATM 4836 O  O   . HOH N 9 .   ? -7.229  -47.057 -17.964 1.00 40.23  ? 1164 HOH A O   1 
HETATM 4837 O  O   . HOH N 9 .   ? -9.905  -63.440 -32.945 1.00 62.03  ? 1165 HOH A O   1 
HETATM 4838 O  O   . HOH N 9 .   ? -10.983 -61.917 -18.786 1.00 26.64  ? 1166 HOH A O   1 
HETATM 4839 O  O   . HOH N 9 .   ? 4.761   -15.826 -21.298 1.00 64.11  ? 1167 HOH A O   1 
HETATM 4840 O  O   . HOH N 9 .   ? -39.344 -55.008 -6.377  1.00 49.98  ? 1168 HOH A O   1 
HETATM 4841 O  O   . HOH N 9 .   ? -14.781 -34.417 -28.696 1.00 29.58  ? 1169 HOH A O   1 
HETATM 4842 O  O   . HOH N 9 .   ? -28.394 -65.983 -0.386  1.00 39.25  ? 1170 HOH A O   1 
HETATM 4843 O  O   . HOH N 9 .   ? -39.014 -60.363 -4.297  1.00 44.21  ? 1171 HOH A O   1 
HETATM 4844 O  O   . HOH N 9 .   ? -4.947  -48.336 -28.504 1.00 33.51  ? 1172 HOH A O   1 
HETATM 4845 O  O   . HOH N 9 .   ? -18.910 -64.795 -7.196  1.00 26.16  ? 1173 HOH A O   1 
HETATM 4846 O  O   . HOH N 9 .   ? -19.032 -69.297 -8.288  1.00 32.26  ? 1174 HOH A O   1 
HETATM 4847 O  O   . HOH N 9 .   ? -22.213 -73.822 -11.796 1.00 39.20  ? 1175 HOH A O   1 
HETATM 4848 O  O   . HOH N 9 .   ? -3.136  -19.746 -22.968 1.00 47.86  ? 1176 HOH A O   1 
HETATM 4849 O  O   . HOH N 9 .   ? -21.123 -40.980 -35.494 1.00 55.53  ? 1177 HOH A O   1 
HETATM 4850 O  O   . HOH N 9 .   ? -29.968 -49.775 -27.104 1.00 52.95  ? 1178 HOH A O   1 
HETATM 4851 O  O   . HOH N 9 .   ? -10.813 -47.670 -38.863 1.00 33.48  ? 1179 HOH A O   1 
HETATM 4852 O  O   . HOH N 9 .   ? 5.890   -38.278 -24.257 1.00 51.22  ? 1180 HOH A O   1 
HETATM 4853 O  O   . HOH N 9 .   ? -9.108  -58.564 -13.315 1.00 33.58  ? 1181 HOH A O   1 
HETATM 4854 O  O   . HOH N 9 .   ? 4.298   -28.677 -43.707 1.00 51.40  ? 1182 HOH A O   1 
HETATM 4855 O  O   . HOH N 9 .   ? -9.297  -21.047 -26.582 1.00 45.39  ? 1183 HOH A O   1 
HETATM 4856 O  O   . HOH N 9 .   ? -21.709 -30.819 -39.164 1.00 54.28  ? 1184 HOH A O   1 
HETATM 4857 O  O   . HOH N 9 .   ? -12.179 -36.319 -39.260 1.00 41.96  ? 1185 HOH A O   1 
HETATM 4858 O  O   . HOH N 9 .   ? -17.754 -41.353 -36.757 1.00 49.68  ? 1186 HOH A O   1 
HETATM 4859 O  O   . HOH N 9 .   ? -3.976  -57.096 -9.704  1.00 44.74  ? 1187 HOH A O   1 
HETATM 4860 O  O   . HOH N 9 .   ? -21.669 -65.662 -4.405  1.00 54.40  ? 1188 HOH A O   1 
HETATM 4861 O  O   . HOH N 9 .   ? 3.870   -37.043 -43.972 1.00 55.24  ? 1189 HOH A O   1 
HETATM 4862 O  O   . HOH N 9 .   ? -15.450 -65.449 -33.890 1.00 60.32  ? 1190 HOH A O   1 
HETATM 4863 O  O   . HOH N 9 .   ? 4.269   -26.163 -29.115 1.00 46.86  ? 1191 HOH A O   1 
HETATM 4864 O  O   . HOH N 9 .   ? -29.859 -59.024 -19.763 1.00 39.71  ? 1192 HOH A O   1 
HETATM 4865 O  O   . HOH N 9 .   ? -16.984 -51.497 -15.342 1.00 25.82  ? 1193 HOH A O   1 
HETATM 4866 O  O   . HOH N 9 .   ? 1.419   -21.294 -45.093 1.00 64.35  ? 1194 HOH A O   1 
HETATM 4867 O  O   . HOH N 9 .   ? -31.765 -59.653 -15.953 1.00 34.39  ? 1195 HOH A O   1 
HETATM 4868 O  O   . HOH N 9 .   ? -9.250  -26.328 -46.700 0.50 49.69  ? 1196 HOH A O   1 
HETATM 4869 O  O   . HOH N 9 .   ? -36.861 -49.754 -5.354  1.00 44.83  ? 1197 HOH A O   1 
HETATM 4870 O  O   . HOH N 9 .   ? -3.958  -52.287 -38.350 1.00 56.83  ? 1198 HOH A O   1 
HETATM 4871 O  O   . HOH N 9 .   ? -41.187 -57.752 -10.084 0.50 43.09  ? 1199 HOH A O   1 
HETATM 4872 O  O   . HOH N 9 .   ? -13.347 -68.068 -6.155  1.00 45.89  ? 1200 HOH A O   1 
HETATM 4873 O  O   . HOH N 9 .   ? -20.146 -45.609 -25.084 1.00 42.11  ? 1201 HOH A O   1 
HETATM 4874 O  O   . HOH N 9 .   ? -24.418 -68.754 -27.736 1.00 50.37  ? 1202 HOH A O   1 
HETATM 4875 O  O   . HOH N 9 .   ? -11.420 -46.815 -43.093 1.00 57.07  ? 1203 HOH A O   1 
HETATM 4876 O  O   . HOH N 9 .   ? -25.042 -53.045 -1.838  1.00 32.42  ? 1204 HOH A O   1 
HETATM 4877 O  O   . HOH N 9 .   ? -8.463  -64.542 -6.831  1.00 41.75  ? 1205 HOH A O   1 
HETATM 4878 O  O   . HOH N 9 .   ? -5.704  -58.762 -11.906 1.00 50.97  ? 1206 HOH A O   1 
HETATM 4879 O  O   . HOH N 9 .   ? -12.639 -53.114 -40.163 1.00 64.72  ? 1207 HOH A O   1 
HETATM 4880 O  O   . HOH N 9 .   ? -27.965 -46.757 0.078   1.00 55.61  ? 1208 HOH A O   1 
HETATM 4881 O  O   . HOH N 9 .   ? 0.133   -64.150 -19.019 1.00 43.27  ? 1209 HOH A O   1 
HETATM 4882 O  O   . HOH N 9 .   ? 5.585   -29.779 -21.314 1.00 41.98  ? 1210 HOH A O   1 
HETATM 4883 O  O   . HOH N 9 .   ? -0.269  -35.476 -27.781 1.00 43.57  ? 1211 HOH A O   1 
HETATM 4884 O  O   . HOH N 9 .   ? -19.163 -20.167 -40.287 1.00 48.01  ? 1212 HOH A O   1 
HETATM 4885 O  O   . HOH N 9 .   ? -28.753 -45.390 2.670   1.00 51.31  ? 1213 HOH A O   1 
HETATM 4886 O  O   . HOH N 9 .   ? -24.061 -33.982 -26.407 0.26 19.65  ? 1214 HOH A O   1 
HETATM 4887 O  O   . HOH N 9 .   ? -19.923 -37.431 -36.289 1.00 39.10  ? 1215 HOH A O   1 
HETATM 4888 O  O   . HOH N 9 .   ? -14.327 -56.099 -1.560  1.00 24.34  ? 1216 HOH A O   1 
HETATM 4889 O  O   . HOH N 9 .   ? -14.811 -53.892 -4.090  1.00 30.29  ? 1217 HOH A O   1 
HETATM 4890 O  O   . HOH N 9 .   ? -9.848  -61.040 -41.944 1.00 69.40  ? 1218 HOH A O   1 
HETATM 4891 O  O   . HOH N 9 .   ? -9.878  -25.142 -11.958 1.00 55.33  ? 1219 HOH A O   1 
HETATM 4892 O  O   . HOH N 9 .   ? -3.917  -22.676 -24.831 1.00 42.58  ? 1220 HOH A O   1 
HETATM 4893 O  O   . HOH N 9 .   ? -24.827 -30.052 -38.832 1.00 60.65  ? 1221 HOH A O   1 
HETATM 4894 O  O   . HOH N 9 .   ? -1.075  -41.429 -21.171 1.00 65.70  ? 1222 HOH A O   1 
HETATM 4895 O  O   . HOH N 9 .   ? -29.564 -62.717 -34.440 1.00 67.08  ? 1223 HOH A O   1 
HETATM 4896 O  O   . HOH N 9 .   ? -22.929 -33.327 -36.403 1.00 39.70  ? 1224 HOH A O   1 
HETATM 4897 O  O   . HOH N 9 .   ? -27.896 -22.804 -26.115 1.00 37.70  ? 1225 HOH A O   1 
HETATM 4898 O  O   . HOH N 9 .   ? -35.370 -59.012 -0.555  1.00 49.01  ? 1226 HOH A O   1 
HETATM 4899 O  O   . HOH N 9 .   ? -4.875  -55.927 -31.470 1.00 36.04  ? 1227 HOH A O   1 
HETATM 4900 O  O   . HOH N 9 .   ? -19.995 -75.772 -14.501 1.00 51.64  ? 1228 HOH A O   1 
HETATM 4901 O  O   . HOH N 9 .   ? -8.998  -70.553 -14.678 1.00 43.00  ? 1229 HOH A O   1 
HETATM 4902 O  O   . HOH N 9 .   ? -18.222 -68.936 -24.694 1.00 39.50  ? 1230 HOH A O   1 
HETATM 4903 O  O   . HOH N 9 .   ? -19.494 -17.017 -10.556 1.00 52.39  ? 1231 HOH A O   1 
HETATM 4904 O  O   . HOH N 9 .   ? -27.801 -16.414 -31.814 1.00 38.91  ? 1232 HOH A O   1 
HETATM 4905 O  O   . HOH N 9 .   ? -4.378  -64.986 -14.881 1.00 42.77  ? 1233 HOH A O   1 
HETATM 4906 O  O   . HOH N 9 .   ? -8.327  -16.233 -38.505 1.00 55.41  ? 1234 HOH A O   1 
HETATM 4907 O  O   . HOH N 9 .   ? -13.694 -53.239 -1.578  1.00 31.17  ? 1235 HOH A O   1 
HETATM 4908 O  O   . HOH N 9 .   ? -35.821 -53.766 -3.332  1.00 34.75  ? 1236 HOH A O   1 
HETATM 4909 O  O   . HOH N 9 .   ? 6.292   -30.924 -19.052 1.00 47.17  ? 1237 HOH A O   1 
HETATM 4910 O  O   . HOH N 9 .   ? -7.507  -57.134 -1.063  1.00 53.15  ? 1238 HOH A O   1 
HETATM 4911 O  O   . HOH N 9 .   ? -14.206 -51.847 -5.670  1.00 31.23  ? 1239 HOH A O   1 
HETATM 4912 O  O   . HOH N 9 .   ? 8.267   -42.515 -35.407 1.00 51.35  ? 1240 HOH A O   1 
HETATM 4913 O  O   . HOH N 9 .   ? -12.418 -31.435 -45.423 1.00 77.15  ? 1241 HOH A O   1 
HETATM 4914 O  O   . HOH N 9 .   ? -33.993 -69.517 -18.619 1.00 41.54  ? 1242 HOH A O   1 
HETATM 4915 O  O   . HOH N 9 .   ? -4.214  -56.736 -13.346 1.00 50.84  ? 1243 HOH A O   1 
HETATM 4916 O  O   . HOH N 9 .   ? -20.630 -66.847 -25.347 1.00 41.64  ? 1244 HOH A O   1 
HETATM 4917 O  O   . HOH N 9 .   ? -17.439 -29.904 -41.123 1.00 60.11  ? 1245 HOH A O   1 
HETATM 4918 O  O   . HOH N 9 .   ? -28.018 -48.699 -31.386 1.00 62.88  ? 1246 HOH A O   1 
HETATM 4919 O  O   . HOH N 9 .   ? -5.823  -48.669 -21.097 1.00 33.15  ? 1247 HOH A O   1 
HETATM 4920 O  O   . HOH N 9 .   ? -11.342 -40.637 -19.563 1.00 54.62  ? 1248 HOH A O   1 
HETATM 4921 O  O   . HOH N 9 .   ? -17.311 -56.705 -43.621 1.00 49.97  ? 1249 HOH A O   1 
HETATM 4922 O  O   . HOH N 9 .   ? -26.628 -71.054 -3.543  1.00 50.14  ? 1250 HOH A O   1 
HETATM 4923 O  O   . HOH N 9 .   ? -41.852 -60.692 -14.653 1.00 55.28  ? 1251 HOH A O   1 
HETATM 4924 O  O   . HOH N 9 .   ? -38.965 -54.548 -19.072 1.00 50.42  ? 1252 HOH A O   1 
HETATM 4925 O  O   . HOH N 9 .   ? -7.520  -71.777 -18.860 1.00 63.55  ? 1253 HOH A O   1 
HETATM 4926 O  O   . HOH N 9 .   ? -39.699 -63.935 -2.163  1.00 51.47  ? 1254 HOH A O   1 
HETATM 4927 O  O   . HOH N 9 .   ? -5.792  -49.879 -18.686 1.00 40.61  ? 1255 HOH A O   1 
HETATM 4928 O  O   . HOH N 9 .   ? -30.061 -60.431 -23.055 1.00 37.07  ? 1256 HOH A O   1 
HETATM 4929 O  O   . HOH N 9 .   ? -2.401  -39.154 -45.515 1.00 54.51  ? 1257 HOH A O   1 
HETATM 4930 O  O   . HOH N 9 .   ? 7.839   -21.649 -23.668 1.00 48.26  ? 1258 HOH A O   1 
HETATM 4931 O  O   . HOH N 9 .   ? 3.079   -43.946 -40.430 1.00 59.40  ? 1259 HOH A O   1 
HETATM 4932 O  O   . HOH N 9 .   ? -5.322  -57.863 -29.842 1.00 53.99  ? 1260 HOH A O   1 
HETATM 4933 O  O   . HOH N 9 .   ? -28.938 -62.279 -25.337 1.00 41.41  ? 1261 HOH A O   1 
HETATM 4934 O  O   . HOH N 9 .   ? -8.625  -37.001 -19.244 1.00 58.19  ? 1262 HOH A O   1 
HETATM 4935 O  O   . HOH N 9 .   ? -31.935 -18.475 -30.509 1.00 51.95  ? 1263 HOH A O   1 
HETATM 4936 O  O   . HOH N 9 .   ? -12.451 -66.519 -29.845 1.00 42.37  ? 1264 HOH A O   1 
HETATM 4937 O  O   . HOH N 9 .   ? -23.797 -44.822 -8.941  1.00 56.04  ? 1265 HOH A O   1 
HETATM 4938 O  O   . HOH N 9 .   ? -27.008 -26.351 -35.179 1.00 44.70  ? 1266 HOH A O   1 
HETATM 4939 O  O   . HOH N 9 .   ? 13.524  -30.033 -19.322 1.00 52.05  ? 1267 HOH A O   1 
HETATM 4940 O  O   . HOH N 9 .   ? -29.869 -56.172 -34.693 1.00 49.69  ? 1268 HOH A O   1 
HETATM 4941 O  O   . HOH N 9 .   ? 6.512   -39.887 -20.758 1.00 69.96  ? 1269 HOH A O   1 
HETATM 4942 O  O   . HOH N 9 .   ? -12.341 -43.315 -16.150 1.00 58.34  ? 1270 HOH A O   1 
HETATM 4943 O  O   . HOH N 9 .   ? 0.080   -47.801 -36.061 1.00 43.37  ? 1271 HOH A O   1 
HETATM 4944 O  O   . HOH N 9 .   ? -7.285  -49.297 -6.086  1.00 62.57  ? 1272 HOH A O   1 
HETATM 4945 O  O   . HOH N 9 .   ? -15.463 -54.361 -43.509 1.00 54.47  ? 1273 HOH A O   1 
HETATM 4946 O  O   . HOH N 9 .   ? 3.543   -23.373 -44.791 1.00 64.68  ? 1274 HOH A O   1 
HETATM 4947 O  O   . HOH N 9 .   ? -5.854  -68.058 -27.441 1.00 38.02  ? 1275 HOH A O   1 
HETATM 4948 O  O   . HOH N 9 .   ? -15.028 -48.302 -18.408 1.00 41.98  ? 1276 HOH A O   1 
HETATM 4949 O  O   . HOH N 9 .   ? -3.794  -70.676 -9.035  1.00 39.49  ? 1277 HOH A O   1 
HETATM 4950 O  O   . HOH N 9 .   ? -23.176 -48.684 -42.223 1.00 42.92  ? 1278 HOH A O   1 
HETATM 4951 O  O   . HOH N 9 .   ? 8.658   -44.598 -29.901 1.00 75.42  ? 1279 HOH A O   1 
HETATM 4952 O  O   . HOH N 9 .   ? 10.401  -28.887 -33.865 1.00 53.82  ? 1280 HOH A O   1 
HETATM 4953 O  O   . HOH N 9 .   ? -26.598 -50.797 -1.958  1.00 53.87  ? 1281 HOH A O   1 
HETATM 4954 O  O   . HOH N 9 .   ? -5.799  -58.292 -36.558 1.00 57.59  ? 1282 HOH A O   1 
HETATM 4955 O  O   . HOH N 9 .   ? -19.483 -64.214 -3.026  1.00 56.53  ? 1283 HOH A O   1 
HETATM 4956 O  O   . HOH N 9 .   ? -8.549  -30.777 -14.972 1.00 66.52  ? 1284 HOH A O   1 
HETATM 4957 O  O   . HOH N 9 .   ? 2.814   -64.102 -20.515 1.00 26.54  ? 1285 HOH A O   1 
HETATM 4958 O  O   . HOH N 9 .   ? 9.918   -37.886 -39.070 1.00 52.43  ? 1286 HOH A O   1 
HETATM 4959 O  O   . HOH N 9 .   ? -37.917 -67.811 -12.598 1.00 53.86  ? 1287 HOH A O   1 
HETATM 4960 O  O   . HOH N 9 .   ? -27.679 -52.027 -41.766 1.00 57.66  ? 1288 HOH A O   1 
HETATM 4961 O  O   . HOH N 9 .   ? 3.588   -31.046 -36.777 1.00 35.77  ? 1289 HOH A O   1 
HETATM 4962 O  O   . HOH N 9 .   ? -9.702  -69.907 -22.657 1.00 54.88  ? 1290 HOH A O   1 
HETATM 4963 O  O   . HOH N 9 .   ? -37.457 -52.027 -12.938 1.00 32.84  ? 1291 HOH A O   1 
HETATM 4964 O  O   . HOH N 9 .   ? -7.787  -29.463 -45.778 0.50 51.54  ? 1292 HOH A O   1 
HETATM 4965 O  O   . HOH N 9 .   ? -16.316 -48.810 -16.186 1.00 28.79  ? 1293 HOH A O   1 
HETATM 4966 O  O   . HOH N 9 .   ? -17.568 -70.997 -22.611 0.50 51.07  ? 1294 HOH A O   1 
HETATM 4967 O  O   . HOH N 9 .   ? -3.913  -56.147 -7.137  1.00 40.49  ? 1295 HOH A O   1 
HETATM 4968 O  O   . HOH N 9 .   ? -5.925  -68.645 -7.422  1.00 39.96  ? 1296 HOH A O   1 
HETATM 4969 O  O   . HOH N 9 .   ? -29.919 -60.973 -32.873 1.00 52.11  ? 1297 HOH A O   1 
HETATM 4970 O  O   . HOH N 9 .   ? -12.046 -36.849 -21.607 1.00 61.69  ? 1298 HOH A O   1 
HETATM 4971 O  O   . HOH N 9 .   ? -6.942  -61.041 -30.879 0.50 47.80  ? 1299 HOH A O   1 
HETATM 4972 O  O   . HOH N 9 .   ? 2.168   -19.591 -19.159 1.00 74.70  ? 1300 HOH A O   1 
HETATM 4973 O  O   . HOH N 9 .   ? 8.753   -40.217 -31.193 1.00 51.55  ? 1301 HOH A O   1 
HETATM 4974 O  O   . HOH N 9 .   ? -7.849  -61.556 -33.444 1.00 49.90  ? 1302 HOH A O   1 
HETATM 4975 O  O   . HOH N 9 .   ? 6.689   -28.718 -43.490 1.00 52.91  ? 1303 HOH A O   1 
HETATM 4976 O  O   . HOH N 9 .   ? -0.680  -32.036 -25.101 1.00 34.00  ? 1304 HOH A O   1 
HETATM 4977 O  O   . HOH N 9 .   ? -2.360  -69.951 -17.531 1.00 49.34  ? 1305 HOH A O   1 
HETATM 4978 O  O   . HOH N 9 .   ? 0.455   -70.310 -21.186 1.00 39.90  ? 1306 HOH A O   1 
HETATM 4979 O  O   . HOH N 9 .   ? 14.679  -30.453 -31.356 1.00 56.22  ? 1307 HOH A O   1 
HETATM 4980 O  O   . HOH N 9 .   ? -9.981  -54.245 -41.500 1.00 66.06  ? 1308 HOH A O   1 
HETATM 4981 O  O   . HOH N 9 .   ? -14.758 -56.259 -41.726 1.00 40.47  ? 1309 HOH A O   1 
HETATM 4982 O  O   . HOH N 9 .   ? -2.920  -57.605 -24.421 1.00 27.72  ? 1310 HOH A O   1 
HETATM 4983 O  O   . HOH N 9 .   ? -35.310 -67.263 -5.593  1.00 56.72  ? 1311 HOH A O   1 
HETATM 4984 O  O   . HOH N 9 .   ? 5.778   -45.001 -26.375 1.00 48.08  ? 1312 HOH A O   1 
HETATM 4985 O  O   . HOH N 9 .   ? -27.203 -73.223 -5.063  1.00 52.37  ? 1313 HOH A O   1 
HETATM 4986 O  O   . HOH N 9 .   ? 3.761   -33.578 -13.895 1.00 51.84  ? 1314 HOH A O   1 
HETATM 4987 O  O   . HOH N 9 .   ? 0.504   -44.954 -36.631 1.00 48.43  ? 1315 HOH A O   1 
HETATM 4988 O  O   . HOH N 9 .   ? -14.058 -43.276 -20.370 1.00 51.02  ? 1316 HOH A O   1 
HETATM 4989 O  O   . HOH N 9 .   ? -4.282  -62.041 -4.522  1.00 45.21  ? 1317 HOH A O   1 
HETATM 4990 O  O   . HOH N 9 .   ? -11.411 -38.998 -39.353 1.00 64.72  ? 1318 HOH A O   1 
HETATM 4991 O  O   . HOH N 9 .   ? -23.395 -47.527 -33.738 1.00 58.81  ? 1319 HOH A O   1 
HETATM 4992 O  O   . HOH N 9 .   ? -31.346 -44.741 -15.595 1.00 63.46  ? 1320 HOH A O   1 
HETATM 4993 O  O   . HOH N 9 .   ? -22.726 -36.961 -36.755 1.00 54.90  ? 1321 HOH A O   1 
HETATM 4994 O  O   . HOH N 9 .   ? 1.192   -38.391 -20.668 1.00 56.11  ? 1322 HOH A O   1 
HETATM 4995 O  O   . HOH N 9 .   ? -24.204 -57.230 -46.788 1.00 54.92  ? 1323 HOH A O   1 
HETATM 4996 O  O   . HOH N 9 .   ? -31.222 -71.338 -13.840 1.00 69.58  ? 1324 HOH A O   1 
HETATM 4997 O  O   . HOH N 9 .   ? -13.088 -32.402 -20.087 1.00 38.96  ? 1325 HOH A O   1 
HETATM 4998 O  O   . HOH N 9 .   ? -11.801 -71.731 -15.873 0.50 38.61  ? 1326 HOH A O   1 
HETATM 4999 O  O   . HOH N 9 .   ? -26.673 -67.268 -27.896 1.00 32.75  ? 1327 HOH A O   1 
HETATM 5000 O  O   . HOH N 9 .   ? -41.666 -23.768 -17.425 1.00 68.96  ? 1328 HOH A O   1 
HETATM 5001 O  O   . HOH N 9 .   ? -7.054  -29.500 -13.151 1.00 64.43  ? 1329 HOH A O   1 
HETATM 5002 O  O   . HOH N 9 .   ? -31.743 -73.675 -16.918 1.00 72.30  ? 1330 HOH A O   1 
HETATM 5003 O  O   . HOH N 9 .   ? 0.752   -30.810 -46.819 1.00 59.04  ? 1331 HOH A O   1 
HETATM 5004 O  O   . HOH N 9 .   ? -37.800 -60.743 -0.643  1.00 66.66  ? 1332 HOH A O   1 
HETATM 5005 O  O   . HOH N 9 .   ? 4.365   -62.047 -20.014 1.00 31.18  ? 1333 HOH A O   1 
HETATM 5006 O  O   . HOH N 9 .   ? -11.584 -69.390 -25.673 1.00 69.06  ? 1334 HOH A O   1 
HETATM 5007 O  O   . HOH N 9 .   ? -11.358 -46.198 3.948   1.00 63.67  ? 1335 HOH A O   1 
HETATM 5008 O  O   . HOH N 9 .   ? -22.865 -74.918 -9.713  0.50 33.74  ? 1336 HOH A O   1 
HETATM 5009 O  O   . HOH N 9 .   ? -25.115 -22.911 -41.055 1.00 72.36  ? 1337 HOH A O   1 
HETATM 5010 O  O   . HOH N 9 .   ? 8.934   -43.204 -32.626 1.00 61.10  ? 1338 HOH A O   1 
HETATM 5011 O  O   . HOH N 9 .   ? 0.017   -45.579 -42.741 1.00 58.43  ? 1339 HOH A O   1 
HETATM 5012 O  O   . HOH N 9 .   ? 11.778  -36.907 -18.974 1.00 49.12  ? 1340 HOH A O   1 
HETATM 5013 O  O   . HOH N 9 .   ? -15.536 -27.012 -45.827 1.00 70.02  ? 1341 HOH A O   1 
HETATM 5014 O  O   . HOH N 9 .   ? 8.300   -47.137 -29.040 0.50 43.96  ? 1342 HOH A O   1 
HETATM 5015 O  O   . HOH N 9 .   ? -16.945 -46.283 -11.162 1.00 54.10  ? 1343 HOH A O   1 
HETATM 5016 O  O   . HOH N 9 .   ? 4.735   -68.713 -21.335 1.00 37.70  ? 1344 HOH A O   1 
HETATM 5017 O  O   . HOH N 9 .   ? 4.944   -50.849 -34.770 1.00 71.57  ? 1345 HOH A O   1 
HETATM 5018 O  O   . HOH N 9 .   ? 0.000   -57.752 -28.533 0.50 36.63  ? 1346 HOH A O   1 
HETATM 5019 O  O   . HOH N 9 .   ? -40.525 -61.800 -3.263  1.00 69.08  ? 1347 HOH A O   1 
HETATM 5020 O  O   . HOH N 9 .   ? -2.961  -55.230 -28.946 1.00 39.32  ? 1348 HOH A O   1 
HETATM 5021 O  O   . HOH N 9 .   ? -34.599 -70.165 -13.656 1.00 64.00  ? 1349 HOH A O   1 
HETATM 5022 O  O   . HOH N 9 .   ? -10.225 -16.679 -39.773 1.00 65.08  ? 1350 HOH A O   1 
HETATM 5023 O  O   . HOH N 9 .   ? -17.700 -27.723 -44.304 1.00 65.77  ? 1351 HOH A O   1 
HETATM 5024 O  O   . HOH N 9 .   ? -42.366 -66.014 -10.426 1.00 59.39  ? 1352 HOH A O   1 
HETATM 5025 O  O   . HOH N 9 .   ? -23.609 -35.299 -34.659 1.00 52.69  ? 1353 HOH A O   1 
HETATM 5026 O  O   . HOH N 9 .   ? -34.240 -49.056 -10.236 1.00 51.07  ? 1354 HOH A O   1 
HETATM 5027 O  O   . HOH N 9 .   ? -4.910  -64.018 -30.785 1.00 61.17  ? 1355 HOH A O   1 
HETATM 5028 O  O   . HOH N 9 .   ? -34.840 -69.709 -9.514  1.00 53.12  ? 1356 HOH A O   1 
HETATM 5029 O  O   . HOH N 9 .   ? -15.418 -41.163 -38.225 1.00 45.95  ? 1357 HOH A O   1 
HETATM 5030 O  O   . HOH N 9 .   ? -38.054 -51.103 -4.068  1.00 56.21  ? 1358 HOH A O   1 
HETATM 5031 O  O   . HOH N 9 .   ? -36.282 -56.071 -4.400  1.00 55.65  ? 1359 HOH A O   1 
HETATM 5032 O  O   . HOH N 9 .   ? -3.521  -51.501 -4.249  1.00 78.50  ? 1360 HOH A O   1 
HETATM 5033 O  O   . HOH N 9 .   ? -2.768  -51.429 -15.057 1.00 62.55  ? 1361 HOH A O   1 
HETATM 5034 O  O   . HOH N 9 .   ? -15.747 -68.642 -6.043  1.00 36.34  ? 1362 HOH A O   1 
HETATM 5035 O  O   . HOH N 9 .   ? 0.000   -57.752 -15.939 0.50 55.94  ? 1363 HOH A O   1 
HETATM 5036 O  O   . HOH N 9 .   ? -13.638 -59.108 -44.761 1.00 68.96  ? 1364 HOH A O   1 
HETATM 5037 O  O   . HOH N 9 .   ? -18.843 -39.348 -38.135 1.00 58.78  ? 1365 HOH A O   1 
HETATM 5038 O  O   . HOH N 9 .   ? -1.907  -64.472 -15.801 1.00 66.94  ? 1366 HOH A O   1 
HETATM 5039 O  O   . HOH N 9 .   ? -37.140 -64.106 0.113   1.00 45.19  ? 1367 HOH A O   1 
HETATM 5040 O  O   . HOH N 9 .   ? -41.162 -56.546 -13.677 1.00 39.34  ? 1368 HOH A O   1 
HETATM 5041 O  O   . HOH N 9 .   ? -1.347  -72.212 -21.515 1.00 69.12  ? 1369 HOH A O   1 
HETATM 5042 O  O   . HOH N 9 .   ? -13.479 -69.274 -23.734 0.50 55.61  ? 1370 HOH A O   1 
HETATM 5043 O  O   . HOH N 9 .   ? -6.538  -74.620 -13.407 0.50 58.40  ? 1371 HOH A O   1 
HETATM 5044 O  O   . HOH N 9 .   ? -10.248 -37.604 -43.314 1.00 57.73  ? 1372 HOH A O   1 
HETATM 5045 O  O   . HOH N 9 .   ? -14.231 -69.136 -20.568 0.50 64.42  ? 1373 HOH A O   1 
HETATM 5046 O  O   . HOH N 9 .   ? -1.088  -62.206 -15.110 1.00 50.90  ? 1374 HOH A O   1 
HETATM 5047 O  O   . HOH N 9 .   ? -18.097 -46.688 -15.792 1.00 51.53  ? 1375 HOH A O   1 
HETATM 5048 O  O   . HOH N 9 .   ? -35.260 -61.981 -28.360 1.00 71.06  ? 1376 HOH A O   1 
HETATM 5049 O  O   . HOH N 9 .   ? -10.560 -67.334 -37.180 1.00 74.45  ? 1377 HOH A O   1 
HETATM 5050 O  O   . HOH N 9 .   ? 0.400   -61.958 -17.487 1.00 45.66  ? 1378 HOH A O   1 
HETATM 5051 O  O   . HOH N 9 .   ? 12.317  -36.017 -30.649 1.00 62.65  ? 1379 HOH A O   1 
HETATM 5052 O  O   . HOH N 9 .   ? 11.229  -19.198 -27.564 1.00 59.08  ? 1380 HOH A O   1 
HETATM 5053 O  O   . HOH N 9 .   ? -4.629  -48.872 3.137   1.00 73.89  ? 1381 HOH A O   1 
HETATM 5054 O  O   . HOH N 9 .   ? 16.771  -34.537 -26.435 1.00 54.34  ? 1382 HOH A O   1 
HETATM 5055 O  O   . HOH N 9 .   ? -16.507 -38.903 -39.570 1.00 62.74  ? 1383 HOH A O   1 
HETATM 5056 O  O   . HOH N 9 .   ? -35.565 -48.412 -23.545 1.00 68.93  ? 1384 HOH A O   1 
HETATM 5057 O  O   . HOH N 9 .   ? -27.335 -29.243 -18.469 1.00 75.75  ? 1385 HOH A O   1 
HETATM 5058 O  O   . HOH N 9 .   ? -2.804  -59.133 -0.575  1.00 57.96  ? 1386 HOH A O   1 
HETATM 5059 O  O   . HOH N 9 .   ? -2.780  -55.766 -33.945 1.00 58.77  ? 1387 HOH A O   1 
HETATM 5060 O  O   . HOH N 9 .   ? -18.347 -67.454 -6.397  1.00 28.10  ? 1388 HOH A O   1 
HETATM 5061 O  O   . HOH N 9 .   ? -35.495 -47.350 -14.149 1.00 64.62  ? 1389 HOH A O   1 
HETATM 5062 O  O   . HOH N 9 .   ? -19.842 -67.756 -4.321  1.00 37.59  ? 1390 HOH A O   1 
HETATM 5063 O  O   . HOH N 9 .   ? -12.075 -36.036 -42.320 1.00 57.80  ? 1391 HOH A O   1 
HETATM 5064 O  O   . HOH N 9 .   ? -16.324 -42.328 -24.340 1.00 58.94  ? 1392 HOH A O   1 
HETATM 5065 O  O   . HOH N 9 .   ? -1.205  -54.830 -0.793  1.00 55.29  ? 1393 HOH A O   1 
HETATM 5066 O  O   . HOH N 9 .   ? -32.279 -66.579 -23.162 1.00 69.35  ? 1394 HOH A O   1 
HETATM 5067 O  O   . HOH N 9 .   ? -4.041  -60.174 -9.966  1.00 56.91  ? 1395 HOH A O   1 
HETATM 5068 O  O   . HOH N 9 .   ? -3.009  -59.206 -6.853  1.00 65.44  ? 1396 HOH A O   1 
HETATM 5069 O  O   . HOH N 9 .   ? -5.423  -63.717 -6.494  1.00 57.91  ? 1397 HOH A O   1 
HETATM 5070 O  O   . HOH N 9 .   ? -1.388  -58.452 -4.155  1.00 65.67  ? 1398 HOH A O   1 
HETATM 5071 O  O   . HOH N 9 .   ? -19.287 -45.713 -18.261 1.00 62.22  ? 1399 HOH A O   1 
HETATM 5072 O  O   . HOH N 9 .   ? -28.123 -54.903 -45.082 1.00 63.76  ? 1400 HOH A O   1 
HETATM 5073 O  O   . HOH N 9 .   ? -44.372 -67.581 -15.453 1.00 59.56  ? 1401 HOH A O   1 
HETATM 5074 O  O   . HOH N 9 .   ? -32.066 -19.296 -5.146  1.00 77.10  ? 1402 HOH A O   1 
HETATM 5075 O  O   . HOH N 9 .   ? 12.044  -20.804 -25.548 1.00 66.23  ? 1403 HOH A O   1 
HETATM 5076 O  O   . HOH N 9 .   ? -42.728 -60.876 -1.693  1.00 62.55  ? 1404 HOH A O   1 
HETATM 5077 O  O   . HOH N 9 .   ? -3.977  -62.346 -8.766  1.00 55.57  ? 1405 HOH A O   1 
HETATM 5078 O  O   . HOH N 9 .   ? 0.000   -57.752 -7.377  0.50 72.49  ? 1406 HOH A O   1 
# 
