data_7I2G
# 
_entry.id   7I2G 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   7I2G         pdb_00007i2g 10.2210/pdb7i2g/pdb 
WWPDB D_1001408231 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-02 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.entry_id                        7I2G 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.recvd_initial_deposition_date   2025-03-06 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.SG_entry                        ? 
_pdbx_database_status.pdb_format_compatible           Y 
_pdbx_database_status.methods_development_category    ? 
# 
_pdbx_contact_author.id                 1 
_pdbx_contact_author.email              fr193@cabm.rutgers.edu 
_pdbx_contact_author.name_first         'Francesc Xavier' 
_pdbx_contact_author.name_last          Ruiz 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0457-0030 
_pdbx_contact_author.name_mi            ? 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Aschenbrenner, J.C.' 1  ? 
'Saini, M.'           2  ? 
'Chopra, A.'          3  ? 
'Marples, P.G.'       4  ? 
'Balcomb, B.H.'       5  ? 
'Lithgo, R.M.'        6  ? 
'Fearon, D.'          7  ? 
'von Delft, F.'       8  ? 
'Ruiz, F.X.'          9  ? 
'Arnold, E.'          10 ? 
# 
_citation.id                        primary 
_citation.title                     
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_volume            ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.year                      ? 
_citation.journal_id_ASTM           ? 
_citation.country                   ? 
_citation.journal_id_ISSN           ? 
_citation.journal_id_CSD            0353 
_citation.book_publisher            ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_DOI      ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.identifier_ORCID 
_citation_author.ordinal 
primary 'Aschenbrenner, J.C.' ? 1  
primary 'Saini, M.'           ? 2  
primary 'Chopra, A.'          ? 3  
primary 'Marples, P.G.'       ? 4  
primary 'Balcomb, B.H.'       ? 5  
primary 'Lithgo, R.M.'        ? 6  
primary 'Fearon, D.'          ? 7  
primary 'von Delft, F.'       ? 8  
primary 'Ruiz, F.X.'          ? 9  
primary 'Arnold, E.'          ? 10 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'NS5 RNA-dependent RNA polymerase'                                 73890.008 1   ? ? ? ? 
2 non-polymer syn 'ZINC ION'                                                         65.409    2   ? ? ? ? 
3 non-polymer syn '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                             195.237   1   ? ? ? ? 
4 non-polymer syn 'DIMETHYL SULFOXIDE'                                               78.133    2   ? ? ? ? 
5 non-polymer syn 'PHOSPHATE ION'                                                    94.971    2   ? ? ? ? 
6 non-polymer syn 'DI(HYDROXYETHYL)ETHER'                                            106.120   1   ? ? ? ? 
7 non-polymer syn 'CHLORIDE ION'                                                     35.453    2   ? ? ? ? 
8 non-polymer syn '6-methyl-2-[(3-methyl-1,2-oxazol-5-yl)methyl]pyridazin-3(2H)-one' 205.213   2   ? ? ? ? 
9 water       nat water                                                              18.015    307 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION'                                                         ZN  
3 '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                             MES 
4 'DIMETHYL SULFOXIDE'                                               DMS 
5 'PHOSPHATE ION'                                                    PO4 
6 'DI(HYDROXYETHYL)ETHER'                                            PEG 
7 'CHLORIDE ION'                                                     CL  
8 '6-methyl-2-[(3-methyl-1,2-oxazol-5-yl)methyl]pyridazin-3(2H)-one' UWS 
9 water                                                              HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PRO n 
1 3   GLY n 
1 4   ILE n 
1 5   GLU n 
1 6   SER n 
1 7   GLU n 
1 8   THR n 
1 9   PRO n 
1 10  ASN n 
1 11  LEU n 
1 12  ASP n 
1 13  ILE n 
1 14  ILE n 
1 15  GLY n 
1 16  LYS n 
1 17  ARG n 
1 18  ILE n 
1 19  GLU n 
1 20  LYS n 
1 21  ILE n 
1 22  LYS n 
1 23  GLN n 
1 24  GLU n 
1 25  HIS n 
1 26  GLU n 
1 27  THR n 
1 28  SER n 
1 29  TRP n 
1 30  HIS n 
1 31  TYR n 
1 32  ASP n 
1 33  GLN n 
1 34  ASP n 
1 35  HIS n 
1 36  PRO n 
1 37  TYR n 
1 38  LYS n 
1 39  THR n 
1 40  TRP n 
1 41  ALA n 
1 42  TYR n 
1 43  HIS n 
1 44  GLY n 
1 45  SER n 
1 46  TYR n 
1 47  GLU n 
1 48  THR n 
1 49  LYS n 
1 50  GLN n 
1 51  THR n 
1 52  GLY n 
1 53  SER n 
1 54  ALA n 
1 55  SER n 
1 56  SER n 
1 57  MET n 
1 58  VAL n 
1 59  ASN n 
1 60  GLY n 
1 61  VAL n 
1 62  VAL n 
1 63  ARG n 
1 64  LEU n 
1 65  LEU n 
1 66  THR n 
1 67  LYS n 
1 68  PRO n 
1 69  TRP n 
1 70  ASP n 
1 71  ILE n 
1 72  ILE n 
1 73  PRO n 
1 74  MET n 
1 75  VAL n 
1 76  THR n 
1 77  GLN n 
1 78  MET n 
1 79  ALA n 
1 80  MET n 
1 81  THR n 
1 82  ASP n 
1 83  THR n 
1 84  THR n 
1 85  PRO n 
1 86  PHE n 
1 87  GLY n 
1 88  GLN n 
1 89  GLN n 
1 90  ARG n 
1 91  VAL n 
1 92  PHE n 
1 93  LYS n 
1 94  GLU n 
1 95  LYS n 
1 96  VAL n 
1 97  ASP n 
1 98  THR n 
1 99  ARG n 
1 100 THR n 
1 101 GLN n 
1 102 GLU n 
1 103 PRO n 
1 104 LYS n 
1 105 GLU n 
1 106 GLY n 
1 107 THR n 
1 108 LYS n 
1 109 LYS n 
1 110 LEU n 
1 111 MET n 
1 112 LYS n 
1 113 ILE n 
1 114 THR n 
1 115 ALA n 
1 116 GLU n 
1 117 TRP n 
1 118 LEU n 
1 119 TRP n 
1 120 LYS n 
1 121 GLU n 
1 122 LEU n 
1 123 GLY n 
1 124 LYS n 
1 125 LYS n 
1 126 LYS n 
1 127 THR n 
1 128 PRO n 
1 129 ARG n 
1 130 MET n 
1 131 CYS n 
1 132 THR n 
1 133 ARG n 
1 134 GLU n 
1 135 GLU n 
1 136 PHE n 
1 137 THR n 
1 138 ARG n 
1 139 LYS n 
1 140 VAL n 
1 141 ARG n 
1 142 SER n 
1 143 ASN n 
1 144 ALA n 
1 145 ALA n 
1 146 LEU n 
1 147 GLY n 
1 148 ALA n 
1 149 ILE n 
1 150 PHE n 
1 151 THR n 
1 152 ASP n 
1 153 GLU n 
1 154 ASN n 
1 155 LYS n 
1 156 TRP n 
1 157 LYS n 
1 158 SER n 
1 159 ALA n 
1 160 ARG n 
1 161 GLU n 
1 162 ALA n 
1 163 VAL n 
1 164 GLU n 
1 165 ASP n 
1 166 SER n 
1 167 GLY n 
1 168 PHE n 
1 169 TRP n 
1 170 GLU n 
1 171 LEU n 
1 172 VAL n 
1 173 ASP n 
1 174 LYS n 
1 175 GLU n 
1 176 ARG n 
1 177 ASN n 
1 178 LEU n 
1 179 HIS n 
1 180 LEU n 
1 181 GLU n 
1 182 GLY n 
1 183 LYS n 
1 184 CYS n 
1 185 GLU n 
1 186 THR n 
1 187 CYS n 
1 188 VAL n 
1 189 TYR n 
1 190 ASN n 
1 191 MET n 
1 192 MET n 
1 193 GLY n 
1 194 LYS n 
1 195 ARG n 
1 196 GLU n 
1 197 LYS n 
1 198 LYS n 
1 199 LEU n 
1 200 GLY n 
1 201 GLU n 
1 202 PHE n 
1 203 GLY n 
1 204 LYS n 
1 205 ALA n 
1 206 LYS n 
1 207 GLY n 
1 208 SER n 
1 209 ARG n 
1 210 ALA n 
1 211 ILE n 
1 212 TRP n 
1 213 TYR n 
1 214 MET n 
1 215 TRP n 
1 216 LEU n 
1 217 GLY n 
1 218 ALA n 
1 219 ARG n 
1 220 PHE n 
1 221 LEU n 
1 222 GLU n 
1 223 PHE n 
1 224 GLU n 
1 225 ALA n 
1 226 LEU n 
1 227 GLY n 
1 228 PHE n 
1 229 LEU n 
1 230 ASN n 
1 231 GLU n 
1 232 ASP n 
1 233 HIS n 
1 234 TRP n 
1 235 PHE n 
1 236 SER n 
1 237 ARG n 
1 238 GLU n 
1 239 ASN n 
1 240 SER n 
1 241 LEU n 
1 242 SER n 
1 243 GLY n 
1 244 VAL n 
1 245 GLU n 
1 246 GLY n 
1 247 GLU n 
1 248 GLY n 
1 249 LEU n 
1 250 HIS n 
1 251 LYS n 
1 252 LEU n 
1 253 GLY n 
1 254 TYR n 
1 255 ILE n 
1 256 LEU n 
1 257 ARG n 
1 258 ASP n 
1 259 VAL n 
1 260 SER n 
1 261 LYS n 
1 262 LYS n 
1 263 GLU n 
1 264 GLY n 
1 265 GLY n 
1 266 ALA n 
1 267 MET n 
1 268 TYR n 
1 269 ALA n 
1 270 ASP n 
1 271 ASP n 
1 272 THR n 
1 273 ALA n 
1 274 GLY n 
1 275 TRP n 
1 276 ASP n 
1 277 THR n 
1 278 ARG n 
1 279 ILE n 
1 280 THR n 
1 281 LEU n 
1 282 GLU n 
1 283 ASP n 
1 284 LEU n 
1 285 LYS n 
1 286 ASN n 
1 287 GLU n 
1 288 GLU n 
1 289 MET n 
1 290 VAL n 
1 291 THR n 
1 292 ASN n 
1 293 HIS n 
1 294 MET n 
1 295 GLU n 
1 296 GLY n 
1 297 GLU n 
1 298 HIS n 
1 299 LYS n 
1 300 LYS n 
1 301 LEU n 
1 302 ALA n 
1 303 GLU n 
1 304 ALA n 
1 305 ILE n 
1 306 PHE n 
1 307 LYS n 
1 308 LEU n 
1 309 THR n 
1 310 TYR n 
1 311 GLN n 
1 312 ASN n 
1 313 LYS n 
1 314 VAL n 
1 315 VAL n 
1 316 ARG n 
1 317 VAL n 
1 318 GLN n 
1 319 ARG n 
1 320 PRO n 
1 321 THR n 
1 322 PRO n 
1 323 ARG n 
1 324 GLY n 
1 325 THR n 
1 326 VAL n 
1 327 MET n 
1 328 ASP n 
1 329 ILE n 
1 330 ILE n 
1 331 SER n 
1 332 ARG n 
1 333 ARG n 
1 334 ASP n 
1 335 GLN n 
1 336 ARG n 
1 337 GLY n 
1 338 SER n 
1 339 GLY n 
1 340 GLN n 
1 341 VAL n 
1 342 VAL n 
1 343 THR n 
1 344 TYR n 
1 345 GLY n 
1 346 LEU n 
1 347 ASN n 
1 348 THR n 
1 349 PHE n 
1 350 THR n 
1 351 ASN n 
1 352 MET n 
1 353 GLU n 
1 354 ALA n 
1 355 GLN n 
1 356 LEU n 
1 357 ILE n 
1 358 ARG n 
1 359 GLN n 
1 360 MET n 
1 361 GLU n 
1 362 GLY n 
1 363 GLU n 
1 364 GLY n 
1 365 VAL n 
1 366 PHE n 
1 367 LYS n 
1 368 SER n 
1 369 ILE n 
1 370 GLN n 
1 371 HIS n 
1 372 LEU n 
1 373 THR n 
1 374 VAL n 
1 375 THR n 
1 376 GLU n 
1 377 GLU n 
1 378 ILE n 
1 379 ALA n 
1 380 VAL n 
1 381 LYS n 
1 382 ASN n 
1 383 TRP n 
1 384 LEU n 
1 385 VAL n 
1 386 ARG n 
1 387 VAL n 
1 388 GLY n 
1 389 ARG n 
1 390 GLU n 
1 391 ARG n 
1 392 LEU n 
1 393 SER n 
1 394 ARG n 
1 395 MET n 
1 396 ALA n 
1 397 ILE n 
1 398 SER n 
1 399 GLY n 
1 400 ASP n 
1 401 ASP n 
1 402 CYS n 
1 403 VAL n 
1 404 VAL n 
1 405 LYS n 
1 406 PRO n 
1 407 LEU n 
1 408 ASP n 
1 409 ASP n 
1 410 ARG n 
1 411 PHE n 
1 412 ALA n 
1 413 SER n 
1 414 ALA n 
1 415 LEU n 
1 416 THR n 
1 417 ALA n 
1 418 LEU n 
1 419 ASN n 
1 420 ASP n 
1 421 MET n 
1 422 GLY n 
1 423 LYS n 
1 424 VAL n 
1 425 ARG n 
1 426 LYS n 
1 427 ASP n 
1 428 ILE n 
1 429 GLN n 
1 430 GLN n 
1 431 TRP n 
1 432 GLU n 
1 433 PRO n 
1 434 SER n 
1 435 ARG n 
1 436 GLY n 
1 437 TRP n 
1 438 ASN n 
1 439 ASP n 
1 440 TRP n 
1 441 THR n 
1 442 GLN n 
1 443 VAL n 
1 444 PRO n 
1 445 PHE n 
1 446 CYS n 
1 447 SER n 
1 448 HIS n 
1 449 HIS n 
1 450 PHE n 
1 451 HIS n 
1 452 GLU n 
1 453 LEU n 
1 454 ILE n 
1 455 MET n 
1 456 LYS n 
1 457 ASP n 
1 458 GLY n 
1 459 ARG n 
1 460 VAL n 
1 461 LEU n 
1 462 VAL n 
1 463 VAL n 
1 464 PRO n 
1 465 CYS n 
1 466 ARG n 
1 467 ASN n 
1 468 GLN n 
1 469 ASP n 
1 470 GLU n 
1 471 LEU n 
1 472 ILE n 
1 473 GLY n 
1 474 ARG n 
1 475 ALA n 
1 476 ARG n 
1 477 ILE n 
1 478 SER n 
1 479 GLN n 
1 480 GLY n 
1 481 ALA n 
1 482 GLY n 
1 483 TRP n 
1 484 SER n 
1 485 LEU n 
1 486 ARG n 
1 487 GLU n 
1 488 THR n 
1 489 ALA n 
1 490 CYS n 
1 491 LEU n 
1 492 GLY n 
1 493 LYS n 
1 494 SER n 
1 495 TYR n 
1 496 ALA n 
1 497 GLN n 
1 498 MET n 
1 499 TRP n 
1 500 SER n 
1 501 LEU n 
1 502 MET n 
1 503 TYR n 
1 504 PHE n 
1 505 HIS n 
1 506 ARG n 
1 507 ARG n 
1 508 ASP n 
1 509 LEU n 
1 510 ARG n 
1 511 LEU n 
1 512 ALA n 
1 513 ALA n 
1 514 ASN n 
1 515 ALA n 
1 516 ILE n 
1 517 CYS n 
1 518 SER n 
1 519 ALA n 
1 520 VAL n 
1 521 PRO n 
1 522 SER n 
1 523 HIS n 
1 524 TRP n 
1 525 VAL n 
1 526 PRO n 
1 527 THR n 
1 528 SER n 
1 529 ARG n 
1 530 THR n 
1 531 THR n 
1 532 TRP n 
1 533 SER n 
1 534 ILE n 
1 535 HIS n 
1 536 ALA n 
1 537 THR n 
1 538 HIS n 
1 539 GLU n 
1 540 TRP n 
1 541 MET n 
1 542 THR n 
1 543 THR n 
1 544 GLU n 
1 545 ASP n 
1 546 MET n 
1 547 LEU n 
1 548 THR n 
1 549 VAL n 
1 550 TRP n 
1 551 ASN n 
1 552 ARG n 
1 553 VAL n 
1 554 TRP n 
1 555 ILE n 
1 556 GLN n 
1 557 GLU n 
1 558 ASN n 
1 559 PRO n 
1 560 TRP n 
1 561 MET n 
1 562 GLU n 
1 563 ASP n 
1 564 LYS n 
1 565 THR n 
1 566 PRO n 
1 567 VAL n 
1 568 GLU n 
1 569 SER n 
1 570 TRP n 
1 571 GLU n 
1 572 GLU n 
1 573 ILE n 
1 574 PRO n 
1 575 TYR n 
1 576 LEU n 
1 577 GLY n 
1 578 LYS n 
1 579 ARG n 
1 580 GLU n 
1 581 ASP n 
1 582 GLN n 
1 583 TRP n 
1 584 CYS n 
1 585 GLY n 
1 586 SER n 
1 587 LEU n 
1 588 ILE n 
1 589 GLY n 
1 590 LEU n 
1 591 THR n 
1 592 SER n 
1 593 ARG n 
1 594 ALA n 
1 595 THR n 
1 596 TRP n 
1 597 ALA n 
1 598 LYS n 
1 599 ASN n 
1 600 ILE n 
1 601 GLN n 
1 602 THR n 
1 603 ALA n 
1 604 ILE n 
1 605 ASN n 
1 606 GLN n 
1 607 VAL n 
1 608 ARG n 
1 609 SER n 
1 610 LEU n 
1 611 ILE n 
1 612 GLY n 
1 613 ASN n 
1 614 GLU n 
1 615 GLU n 
1 616 TYR n 
1 617 THR n 
1 618 ASP n 
1 619 TYR n 
1 620 MET n 
1 621 PRO n 
1 622 SER n 
1 623 MET n 
1 624 LYS n 
1 625 ARG n 
1 626 PHE n 
1 627 ARG n 
1 628 ARG n 
1 629 GLU n 
1 630 GLU n 
1 631 GLU n 
1 632 GLU n 
1 633 ALA n 
1 634 GLY n 
1 635 VAL n 
1 636 LEU n 
1 637 TRP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   637 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'dengue virus type 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     11060 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                                            ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                                           ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                                         ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                                    ? 'C4 H7 N O4'     133.103 
CL  non-polymer         . 'CHLORIDE ION'                                                     ? 'Cl -1'          35.453  
CYS 'L-peptide linking' y CYSTEINE                                                           ? 'C3 H7 N O2 S'   121.158 
DMS non-polymer         . 'DIMETHYL SULFOXIDE'                                               ? 'C2 H6 O S'      78.133  
GLN 'L-peptide linking' y GLUTAMINE                                                          ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                                    ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                                            ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                                          ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                                              ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                                         ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                                            ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                                             ? 'C6 H15 N2 O2 1' 147.195 
MES non-polymer         . '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                             ? 'C6 H13 N O4 S'  195.237 
MET 'L-peptide linking' y METHIONINE                                                         ? 'C5 H11 N O2 S'  149.211 
PEG non-polymer         . 'DI(HYDROXYETHYL)ETHER'                                            ? 'C4 H10 O3'      106.120 
PHE 'L-peptide linking' y PHENYLALANINE                                                      ? 'C9 H11 N O2'    165.189 
PO4 non-polymer         . 'PHOSPHATE ION'                                                    ? 'O4 P -3'        94.971  
PRO 'L-peptide linking' y PROLINE                                                            ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                                             ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                                          ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                                         ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                                           ? 'C9 H11 N O3'    181.189 
UWS non-polymer         . '6-methyl-2-[(3-methyl-1,2-oxazol-5-yl)methyl]pyridazin-3(2H)-one' ? 'C10 H11 N3 O2'  205.213 
VAL 'L-peptide linking' y VALINE                                                             ? 'C5 H11 N O2'    117.146 
ZN  non-polymer         . 'ZINC ION'                                                         ? 'Zn 2'           65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   264 ?   ?   ?   A . n 
A 1 2   PRO 2   265 ?   ?   ?   A . n 
A 1 3   GLY 3   266 ?   ?   ?   A . n 
A 1 4   ILE 4   267 ?   ?   ?   A . n 
A 1 5   GLU 5   268 ?   ?   ?   A . n 
A 1 6   SER 6   269 ?   ?   ?   A . n 
A 1 7   GLU 7   270 ?   ?   ?   A . n 
A 1 8   THR 8   271 ?   ?   ?   A . n 
A 1 9   PRO 9   272 ?   ?   ?   A . n 
A 1 10  ASN 10  273 273 ASN ASN A . n 
A 1 11  LEU 11  274 274 LEU LEU A . n 
A 1 12  ASP 12  275 275 ASP ASP A . n 
A 1 13  ILE 13  276 276 ILE ILE A . n 
A 1 14  ILE 14  277 277 ILE ILE A . n 
A 1 15  GLY 15  278 278 GLY GLY A . n 
A 1 16  LYS 16  279 279 LYS LYS A . n 
A 1 17  ARG 17  280 280 ARG ARG A . n 
A 1 18  ILE 18  281 281 ILE ILE A . n 
A 1 19  GLU 19  282 282 GLU GLU A . n 
A 1 20  LYS 20  283 283 LYS LYS A . n 
A 1 21  ILE 21  284 284 ILE ILE A . n 
A 1 22  LYS 22  285 285 LYS LYS A . n 
A 1 23  GLN 23  286 286 GLN GLN A . n 
A 1 24  GLU 24  287 287 GLU GLU A . n 
A 1 25  HIS 25  288 288 HIS HIS A . n 
A 1 26  GLU 26  289 289 GLU GLU A . n 
A 1 27  THR 27  290 290 THR THR A . n 
A 1 28  SER 28  291 291 SER SER A . n 
A 1 29  TRP 29  292 292 TRP TRP A . n 
A 1 30  HIS 30  293 293 HIS HIS A . n 
A 1 31  TYR 31  294 294 TYR TYR A . n 
A 1 32  ASP 32  295 295 ASP ASP A . n 
A 1 33  GLN 33  296 296 GLN GLN A . n 
A 1 34  ASP 34  297 297 ASP ASP A . n 
A 1 35  HIS 35  298 298 HIS HIS A . n 
A 1 36  PRO 36  299 299 PRO PRO A . n 
A 1 37  TYR 37  300 300 TYR TYR A . n 
A 1 38  LYS 38  301 301 LYS LYS A . n 
A 1 39  THR 39  302 302 THR THR A . n 
A 1 40  TRP 40  303 303 TRP TRP A . n 
A 1 41  ALA 41  304 304 ALA ALA A . n 
A 1 42  TYR 42  305 305 TYR TYR A . n 
A 1 43  HIS 43  306 306 HIS HIS A . n 
A 1 44  GLY 44  307 307 GLY GLY A . n 
A 1 45  SER 45  308 308 SER SER A . n 
A 1 46  TYR 46  309 309 TYR TYR A . n 
A 1 47  GLU 47  310 310 GLU GLU A . n 
A 1 48  THR 48  311 311 THR THR A . n 
A 1 49  LYS 49  312 ?   ?   ?   A . n 
A 1 50  GLN 50  313 ?   ?   ?   A . n 
A 1 51  THR 51  314 ?   ?   ?   A . n 
A 1 52  GLY 52  315 ?   ?   ?   A . n 
A 1 53  SER 53  316 ?   ?   ?   A . n 
A 1 54  ALA 54  317 317 ALA ALA A . n 
A 1 55  SER 55  318 318 SER SER A . n 
A 1 56  SER 56  319 319 SER SER A . n 
A 1 57  MET 57  320 320 MET MET A . n 
A 1 58  VAL 58  321 321 VAL VAL A . n 
A 1 59  ASN 59  322 322 ASN ASN A . n 
A 1 60  GLY 60  323 323 GLY GLY A . n 
A 1 61  VAL 61  324 324 VAL VAL A . n 
A 1 62  VAL 62  325 325 VAL VAL A . n 
A 1 63  ARG 63  326 326 ARG ARG A . n 
A 1 64  LEU 64  327 327 LEU LEU A . n 
A 1 65  LEU 65  328 328 LEU LEU A . n 
A 1 66  THR 66  329 329 THR THR A . n 
A 1 67  LYS 67  330 330 LYS LYS A . n 
A 1 68  PRO 68  331 331 PRO PRO A . n 
A 1 69  TRP 69  332 332 TRP TRP A . n 
A 1 70  ASP 70  333 333 ASP ASP A . n 
A 1 71  ILE 71  334 334 ILE ILE A . n 
A 1 72  ILE 72  335 335 ILE ILE A . n 
A 1 73  PRO 73  336 336 PRO PRO A . n 
A 1 74  MET 74  337 337 MET MET A . n 
A 1 75  VAL 75  338 338 VAL VAL A . n 
A 1 76  THR 76  339 339 THR THR A . n 
A 1 77  GLN 77  340 340 GLN GLN A . n 
A 1 78  MET 78  341 341 MET MET A . n 
A 1 79  ALA 79  342 342 ALA ALA A . n 
A 1 80  MET 80  343 343 MET MET A . n 
A 1 81  THR 81  344 344 THR GLY A . n 
A 1 82  ASP 82  345 ?   ?   ?   A . n 
A 1 83  THR 83  346 ?   ?   ?   A . n 
A 1 84  THR 84  347 ?   ?   ?   A . n 
A 1 85  PRO 85  348 ?   ?   ?   A . n 
A 1 86  PHE 86  349 ?   ?   ?   A . n 
A 1 87  GLY 87  350 ?   ?   ?   A . n 
A 1 88  GLN 88  351 ?   ?   ?   A . n 
A 1 89  GLN 89  352 ?   ?   ?   A . n 
A 1 90  ARG 90  353 ?   ?   ?   A . n 
A 1 91  VAL 91  354 ?   ?   ?   A . n 
A 1 92  PHE 92  355 ?   ?   ?   A . n 
A 1 93  LYS 93  356 ?   ?   ?   A . n 
A 1 94  GLU 94  357 357 GLU GLU A . n 
A 1 95  LYS 95  358 358 LYS LYS A . n 
A 1 96  VAL 96  359 359 VAL VAL A . n 
A 1 97  ASP 97  360 360 ASP ASP A . n 
A 1 98  THR 98  361 361 THR THR A . n 
A 1 99  ARG 99  362 362 ARG ARG A . n 
A 1 100 THR 100 363 363 THR THR A . n 
A 1 101 GLN 101 364 364 GLN GLN A . n 
A 1 102 GLU 102 365 365 GLU GLU A . n 
A 1 103 PRO 103 366 366 PRO PRO A . n 
A 1 104 LYS 104 367 367 LYS LYS A . n 
A 1 105 GLU 105 368 368 GLU GLU A . n 
A 1 106 GLY 106 369 369 GLY GLY A . n 
A 1 107 THR 107 370 370 THR THR A . n 
A 1 108 LYS 108 371 371 LYS LYS A . n 
A 1 109 LYS 109 372 372 LYS LYS A . n 
A 1 110 LEU 110 373 373 LEU LEU A . n 
A 1 111 MET 111 374 374 MET MET A . n 
A 1 112 LYS 112 375 375 LYS LYS A . n 
A 1 113 ILE 113 376 376 ILE ILE A . n 
A 1 114 THR 114 377 377 THR THR A . n 
A 1 115 ALA 115 378 378 ALA ALA A . n 
A 1 116 GLU 116 379 379 GLU GLU A . n 
A 1 117 TRP 117 380 380 TRP TRP A . n 
A 1 118 LEU 118 381 381 LEU LEU A . n 
A 1 119 TRP 119 382 382 TRP TRP A . n 
A 1 120 LYS 120 383 383 LYS LYS A . n 
A 1 121 GLU 121 384 384 GLU GLU A . n 
A 1 122 LEU 122 385 385 LEU LEU A . n 
A 1 123 GLY 123 386 386 GLY GLY A . n 
A 1 124 LYS 124 387 387 LYS LYS A . n 
A 1 125 LYS 125 388 388 LYS LYS A . n 
A 1 126 LYS 126 389 389 LYS LYS A . n 
A 1 127 THR 127 390 390 THR THR A . n 
A 1 128 PRO 128 391 391 PRO PRO A . n 
A 1 129 ARG 129 392 392 ARG ARG A . n 
A 1 130 MET 130 393 393 MET MET A . n 
A 1 131 CYS 131 394 394 CYS CYS A . n 
A 1 132 THR 132 395 395 THR THR A . n 
A 1 133 ARG 133 396 396 ARG ARG A . n 
A 1 134 GLU 134 397 397 GLU GLU A . n 
A 1 135 GLU 135 398 398 GLU GLU A . n 
A 1 136 PHE 136 399 399 PHE PHE A . n 
A 1 137 THR 137 400 400 THR THR A . n 
A 1 138 ARG 138 401 401 ARG ARG A . n 
A 1 139 LYS 139 402 402 LYS LYS A . n 
A 1 140 VAL 140 403 403 VAL VAL A . n 
A 1 141 ARG 141 404 404 ARG ARG A . n 
A 1 142 SER 142 405 405 SER SER A . n 
A 1 143 ASN 143 406 406 ASN ASN A . n 
A 1 144 ALA 144 407 407 ALA ALA A . n 
A 1 145 ALA 145 408 408 ALA ALA A . n 
A 1 146 LEU 146 409 409 LEU LEU A . n 
A 1 147 GLY 147 410 410 GLY GLY A . n 
A 1 148 ALA 148 411 411 ALA ALA A . n 
A 1 149 ILE 149 412 412 ILE ILE A . n 
A 1 150 PHE 150 413 ?   ?   ?   A . n 
A 1 151 THR 151 414 ?   ?   ?   A . n 
A 1 152 ASP 152 415 ?   ?   ?   A . n 
A 1 153 GLU 153 416 ?   ?   ?   A . n 
A 1 154 ASN 154 417 ?   ?   ?   A . n 
A 1 155 LYS 155 418 418 LYS LYS A . n 
A 1 156 TRP 156 419 419 TRP TRP A . n 
A 1 157 LYS 157 420 420 LYS LYS A . n 
A 1 158 SER 158 421 421 SER SER A . n 
A 1 159 ALA 159 422 422 ALA ALA A . n 
A 1 160 ARG 160 423 423 ARG ARG A . n 
A 1 161 GLU 161 424 424 GLU GLU A . n 
A 1 162 ALA 162 425 425 ALA ALA A . n 
A 1 163 VAL 163 426 426 VAL VAL A . n 
A 1 164 GLU 164 427 427 GLU GLU A . n 
A 1 165 ASP 165 428 428 ASP ASP A . n 
A 1 166 SER 166 429 429 SER SER A . n 
A 1 167 GLY 167 430 430 GLY GLY A . n 
A 1 168 PHE 168 431 431 PHE PHE A . n 
A 1 169 TRP 169 432 432 TRP TRP A . n 
A 1 170 GLU 170 433 433 GLU GLU A . n 
A 1 171 LEU 171 434 434 LEU LEU A . n 
A 1 172 VAL 172 435 435 VAL VAL A . n 
A 1 173 ASP 173 436 436 ASP ASP A . n 
A 1 174 LYS 174 437 437 LYS LYS A . n 
A 1 175 GLU 175 438 438 GLU GLU A . n 
A 1 176 ARG 176 439 439 ARG ARG A . n 
A 1 177 ASN 177 440 440 ASN ASN A . n 
A 1 178 LEU 178 441 441 LEU LEU A . n 
A 1 179 HIS 179 442 442 HIS HIS A . n 
A 1 180 LEU 180 443 443 LEU LEU A . n 
A 1 181 GLU 181 444 444 GLU GLU A . n 
A 1 182 GLY 182 445 445 GLY GLY A . n 
A 1 183 LYS 183 446 446 LYS LYS A . n 
A 1 184 CYS 184 447 447 CYS CYS A . n 
A 1 185 GLU 185 448 448 GLU GLU A . n 
A 1 186 THR 186 449 449 THR THR A . n 
A 1 187 CYS 187 450 450 CYS CYS A . n 
A 1 188 VAL 188 451 451 VAL VAL A . n 
A 1 189 TYR 189 452 452 TYR TYR A . n 
A 1 190 ASN 190 453 453 ASN ASN A . n 
A 1 191 MET 191 454 454 MET MET A . n 
A 1 192 MET 192 455 455 MET MET A . n 
A 1 193 GLY 193 456 ?   ?   ?   A . n 
A 1 194 LYS 194 457 ?   ?   ?   A . n 
A 1 195 ARG 195 458 ?   ?   ?   A . n 
A 1 196 GLU 196 459 ?   ?   ?   A . n 
A 1 197 LYS 197 460 ?   ?   ?   A . n 
A 1 198 LYS 198 461 ?   ?   ?   A . n 
A 1 199 LEU 199 462 ?   ?   ?   A . n 
A 1 200 GLY 200 463 ?   ?   ?   A . n 
A 1 201 GLU 201 464 ?   ?   ?   A . n 
A 1 202 PHE 202 465 ?   ?   ?   A . n 
A 1 203 GLY 203 466 ?   ?   ?   A . n 
A 1 204 LYS 204 467 ?   ?   ?   A . n 
A 1 205 ALA 205 468 ?   ?   ?   A . n 
A 1 206 LYS 206 469 ?   ?   ?   A . n 
A 1 207 GLY 207 470 ?   ?   ?   A . n 
A 1 208 SER 208 471 ?   ?   ?   A . n 
A 1 209 ARG 209 472 ?   ?   ?   A . n 
A 1 210 ALA 210 473 ?   ?   ?   A . n 
A 1 211 ILE 211 474 474 ILE ILE A . n 
A 1 212 TRP 212 475 475 TRP TRP A . n 
A 1 213 TYR 213 476 476 TYR TYR A . n 
A 1 214 MET 214 477 477 MET MET A . n 
A 1 215 TRP 215 478 478 TRP TRP A . n 
A 1 216 LEU 216 479 479 LEU LEU A . n 
A 1 217 GLY 217 480 480 GLY GLY A . n 
A 1 218 ALA 218 481 481 ALA ALA A . n 
A 1 219 ARG 219 482 482 ARG ARG A . n 
A 1 220 PHE 220 483 483 PHE PHE A . n 
A 1 221 LEU 221 484 484 LEU LEU A . n 
A 1 222 GLU 222 485 485 GLU GLU A . n 
A 1 223 PHE 223 486 486 PHE PHE A . n 
A 1 224 GLU 224 487 487 GLU GLU A . n 
A 1 225 ALA 225 488 488 ALA ALA A . n 
A 1 226 LEU 226 489 489 LEU LEU A . n 
A 1 227 GLY 227 490 490 GLY GLY A . n 
A 1 228 PHE 228 491 491 PHE PHE A . n 
A 1 229 LEU 229 492 492 LEU LEU A . n 
A 1 230 ASN 230 493 493 ASN ASN A . n 
A 1 231 GLU 231 494 494 GLU GLU A . n 
A 1 232 ASP 232 495 495 ASP ASP A . n 
A 1 233 HIS 233 496 496 HIS HIS A . n 
A 1 234 TRP 234 497 497 TRP TRP A . n 
A 1 235 PHE 235 498 498 PHE PHE A . n 
A 1 236 SER 236 499 499 SER SER A . n 
A 1 237 ARG 237 500 500 ARG ARG A . n 
A 1 238 GLU 238 501 501 GLU GLU A . n 
A 1 239 ASN 239 502 502 ASN ASN A . n 
A 1 240 SER 240 503 503 SER SER A . n 
A 1 241 LEU 241 504 504 LEU LEU A . n 
A 1 242 SER 242 505 505 SER SER A . n 
A 1 243 GLY 243 506 506 GLY GLY A . n 
A 1 244 VAL 244 507 507 VAL VAL A . n 
A 1 245 GLU 245 508 508 GLU GLU A . n 
A 1 246 GLY 246 509 509 GLY GLY A . n 
A 1 247 GLU 247 510 510 GLU GLU A . n 
A 1 248 GLY 248 511 511 GLY GLY A . n 
A 1 249 LEU 249 512 512 LEU LEU A . n 
A 1 250 HIS 250 513 513 HIS HIS A . n 
A 1 251 LYS 251 514 514 LYS LYS A . n 
A 1 252 LEU 252 515 515 LEU LEU A . n 
A 1 253 GLY 253 516 516 GLY GLY A . n 
A 1 254 TYR 254 517 517 TYR TYR A . n 
A 1 255 ILE 255 518 518 ILE ILE A . n 
A 1 256 LEU 256 519 519 LEU LEU A . n 
A 1 257 ARG 257 520 520 ARG ARG A . n 
A 1 258 ASP 258 521 521 ASP ASP A . n 
A 1 259 VAL 259 522 522 VAL VAL A . n 
A 1 260 SER 260 523 523 SER SER A . n 
A 1 261 LYS 261 524 524 LYS LYS A . n 
A 1 262 LYS 262 525 525 LYS LYS A . n 
A 1 263 GLU 263 526 526 GLU GLU A . n 
A 1 264 GLY 264 527 527 GLY GLY A . n 
A 1 265 GLY 265 528 528 GLY GLY A . n 
A 1 266 ALA 266 529 529 ALA ALA A . n 
A 1 267 MET 267 530 530 MET MET A . n 
A 1 268 TYR 268 531 531 TYR TYR A . n 
A 1 269 ALA 269 532 532 ALA ALA A . n 
A 1 270 ASP 270 533 533 ASP ASP A . n 
A 1 271 ASP 271 534 534 ASP ASP A . n 
A 1 272 THR 272 535 535 THR THR A . n 
A 1 273 ALA 273 536 536 ALA ALA A . n 
A 1 274 GLY 274 537 537 GLY GLY A . n 
A 1 275 TRP 275 538 538 TRP TRP A . n 
A 1 276 ASP 276 539 539 ASP ASP A . n 
A 1 277 THR 277 540 540 THR THR A . n 
A 1 278 ARG 278 541 541 ARG ARG A . n 
A 1 279 ILE 279 542 542 ILE ILE A . n 
A 1 280 THR 280 543 543 THR THR A . n 
A 1 281 LEU 281 544 544 LEU LEU A . n 
A 1 282 GLU 282 545 545 GLU GLU A . n 
A 1 283 ASP 283 546 546 ASP ASP A . n 
A 1 284 LEU 284 547 547 LEU LEU A . n 
A 1 285 LYS 285 548 548 LYS LYS A . n 
A 1 286 ASN 286 549 549 ASN ASN A . n 
A 1 287 GLU 287 550 550 GLU GLU A . n 
A 1 288 GLU 288 551 551 GLU GLU A . n 
A 1 289 MET 289 552 552 MET MET A . n 
A 1 290 VAL 290 553 553 VAL VAL A . n 
A 1 291 THR 291 554 554 THR THR A . n 
A 1 292 ASN 292 555 555 ASN ASN A . n 
A 1 293 HIS 293 556 556 HIS HIS A . n 
A 1 294 MET 294 557 557 MET MET A . n 
A 1 295 GLU 295 558 558 GLU GLU A . n 
A 1 296 GLY 296 559 559 GLY GLY A . n 
A 1 297 GLU 297 560 560 GLU GLU A . n 
A 1 298 HIS 298 561 561 HIS HIS A . n 
A 1 299 LYS 299 562 562 LYS LYS A . n 
A 1 300 LYS 300 563 563 LYS LYS A . n 
A 1 301 LEU 301 564 564 LEU LEU A . n 
A 1 302 ALA 302 565 565 ALA ALA A . n 
A 1 303 GLU 303 566 566 GLU GLU A . n 
A 1 304 ALA 304 567 567 ALA ALA A . n 
A 1 305 ILE 305 568 568 ILE ILE A . n 
A 1 306 PHE 306 569 569 PHE PHE A . n 
A 1 307 LYS 307 570 570 LYS LYS A . n 
A 1 308 LEU 308 571 571 LEU LEU A . n 
A 1 309 THR 309 572 572 THR THR A . n 
A 1 310 TYR 310 573 573 TYR TYR A . n 
A 1 311 GLN 311 574 574 GLN GLN A . n 
A 1 312 ASN 312 575 575 ASN ASN A . n 
A 1 313 LYS 313 576 576 LYS LYS A . n 
A 1 314 VAL 314 577 577 VAL VAL A . n 
A 1 315 VAL 315 578 578 VAL VAL A . n 
A 1 316 ARG 316 579 579 ARG ARG A . n 
A 1 317 VAL 317 580 580 VAL VAL A . n 
A 1 318 GLN 318 581 581 GLN GLN A . n 
A 1 319 ARG 319 582 582 ARG ARG A . n 
A 1 320 PRO 320 583 583 PRO PRO A . n 
A 1 321 THR 321 584 584 THR THR A . n 
A 1 322 PRO 322 585 ?   ?   ?   A . n 
A 1 323 ARG 323 586 ?   ?   ?   A . n 
A 1 324 GLY 324 587 ?   ?   ?   A . n 
A 1 325 THR 325 588 588 THR THR A . n 
A 1 326 VAL 326 589 589 VAL VAL A . n 
A 1 327 MET 327 590 590 MET MET A . n 
A 1 328 ASP 328 591 591 ASP ASP A . n 
A 1 329 ILE 329 592 592 ILE ILE A . n 
A 1 330 ILE 330 593 593 ILE ILE A . n 
A 1 331 SER 331 594 594 SER SER A . n 
A 1 332 ARG 332 595 595 ARG ARG A . n 
A 1 333 ARG 333 596 596 ARG ARG A . n 
A 1 334 ASP 334 597 597 ASP ASP A . n 
A 1 335 GLN 335 598 598 GLN GLN A . n 
A 1 336 ARG 336 599 599 ARG ARG A . n 
A 1 337 GLY 337 600 600 GLY GLY A . n 
A 1 338 SER 338 601 601 SER SER A . n 
A 1 339 GLY 339 602 602 GLY GLY A . n 
A 1 340 GLN 340 603 603 GLN GLN A . n 
A 1 341 VAL 341 604 604 VAL VAL A . n 
A 1 342 VAL 342 605 605 VAL VAL A . n 
A 1 343 THR 343 606 606 THR THR A . n 
A 1 344 TYR 344 607 607 TYR TYR A . n 
A 1 345 GLY 345 608 608 GLY GLY A . n 
A 1 346 LEU 346 609 609 LEU LEU A . n 
A 1 347 ASN 347 610 610 ASN ASN A . n 
A 1 348 THR 348 611 611 THR THR A . n 
A 1 349 PHE 349 612 612 PHE PHE A . n 
A 1 350 THR 350 613 613 THR THR A . n 
A 1 351 ASN 351 614 614 ASN ASN A . n 
A 1 352 MET 352 615 615 MET MET A . n 
A 1 353 GLU 353 616 616 GLU GLU A . n 
A 1 354 ALA 354 617 617 ALA ALA A . n 
A 1 355 GLN 355 618 618 GLN GLN A . n 
A 1 356 LEU 356 619 619 LEU LEU A . n 
A 1 357 ILE 357 620 620 ILE ILE A . n 
A 1 358 ARG 358 621 621 ARG ARG A . n 
A 1 359 GLN 359 622 622 GLN GLN A . n 
A 1 360 MET 360 623 623 MET MET A . n 
A 1 361 GLU 361 624 624 GLU GLU A . n 
A 1 362 GLY 362 625 625 GLY GLY A . n 
A 1 363 GLU 363 626 626 GLU GLU A . n 
A 1 364 GLY 364 627 627 GLY GLY A . n 
A 1 365 VAL 365 628 628 VAL VAL A . n 
A 1 366 PHE 366 629 629 PHE PHE A . n 
A 1 367 LYS 367 630 630 LYS LYS A . n 
A 1 368 SER 368 631 631 SER SER A . n 
A 1 369 ILE 369 632 632 ILE ILE A . n 
A 1 370 GLN 370 633 633 GLN GLN A . n 
A 1 371 HIS 371 634 634 HIS HIS A . n 
A 1 372 LEU 372 635 635 LEU LEU A . n 
A 1 373 THR 373 636 636 THR THR A . n 
A 1 374 VAL 374 637 637 VAL VAL A . n 
A 1 375 THR 375 638 638 THR THR A . n 
A 1 376 GLU 376 639 639 GLU GLU A . n 
A 1 377 GLU 377 640 640 GLU GLU A . n 
A 1 378 ILE 378 641 641 ILE ILE A . n 
A 1 379 ALA 379 642 642 ALA ALA A . n 
A 1 380 VAL 380 643 643 VAL VAL A . n 
A 1 381 LYS 381 644 644 LYS LYS A . n 
A 1 382 ASN 382 645 645 ASN ASN A . n 
A 1 383 TRP 383 646 646 TRP TRP A . n 
A 1 384 LEU 384 647 647 LEU LEU A . n 
A 1 385 VAL 385 648 648 VAL VAL A . n 
A 1 386 ARG 386 649 649 ARG ARG A . n 
A 1 387 VAL 387 650 650 VAL VAL A . n 
A 1 388 GLY 388 651 651 GLY GLY A . n 
A 1 389 ARG 389 652 652 ARG ARG A . n 
A 1 390 GLU 390 653 653 GLU GLU A . n 
A 1 391 ARG 391 654 654 ARG ARG A . n 
A 1 392 LEU 392 655 655 LEU LEU A . n 
A 1 393 SER 393 656 656 SER SER A . n 
A 1 394 ARG 394 657 657 ARG ARG A . n 
A 1 395 MET 395 658 658 MET MET A . n 
A 1 396 ALA 396 659 659 ALA ALA A . n 
A 1 397 ILE 397 660 660 ILE ILE A . n 
A 1 398 SER 398 661 661 SER SER A . n 
A 1 399 GLY 399 662 662 GLY GLY A . n 
A 1 400 ASP 400 663 663 ASP ASP A . n 
A 1 401 ASP 401 664 664 ASP ASP A . n 
A 1 402 CYS 402 665 665 CYS CYS A . n 
A 1 403 VAL 403 666 666 VAL VAL A . n 
A 1 404 VAL 404 667 667 VAL VAL A . n 
A 1 405 LYS 405 668 668 LYS LYS A . n 
A 1 406 PRO 406 669 669 PRO PRO A . n 
A 1 407 LEU 407 670 670 LEU LEU A . n 
A 1 408 ASP 408 671 671 ASP ASP A . n 
A 1 409 ASP 409 672 672 ASP ASP A . n 
A 1 410 ARG 410 673 673 ARG ARG A . n 
A 1 411 PHE 411 674 674 PHE PHE A . n 
A 1 412 ALA 412 675 675 ALA ALA A . n 
A 1 413 SER 413 676 676 SER SER A . n 
A 1 414 ALA 414 677 677 ALA ALA A . n 
A 1 415 LEU 415 678 678 LEU LEU A . n 
A 1 416 THR 416 679 679 THR THR A . n 
A 1 417 ALA 417 680 680 ALA ALA A . n 
A 1 418 LEU 418 681 681 LEU LEU A . n 
A 1 419 ASN 419 682 682 ASN ASN A . n 
A 1 420 ASP 420 683 683 ASP ASP A . n 
A 1 421 MET 421 684 684 MET MET A . n 
A 1 422 GLY 422 685 685 GLY GLY A . n 
A 1 423 LYS 423 686 686 LYS LYS A . n 
A 1 424 VAL 424 687 687 VAL VAL A . n 
A 1 425 ARG 425 688 688 ARG ARG A . n 
A 1 426 LYS 426 689 689 LYS LYS A . n 
A 1 427 ASP 427 690 690 ASP ASP A . n 
A 1 428 ILE 428 691 691 ILE ILE A . n 
A 1 429 GLN 429 692 692 GLN GLN A . n 
A 1 430 GLN 430 693 693 GLN GLN A . n 
A 1 431 TRP 431 694 694 TRP TRP A . n 
A 1 432 GLU 432 695 695 GLU GLU A . n 
A 1 433 PRO 433 696 696 PRO PRO A . n 
A 1 434 SER 434 697 697 SER SER A . n 
A 1 435 ARG 435 698 698 ARG ARG A . n 
A 1 436 GLY 436 699 699 GLY GLY A . n 
A 1 437 TRP 437 700 700 TRP TRP A . n 
A 1 438 ASN 438 701 701 ASN ASN A . n 
A 1 439 ASP 439 702 702 ASP ASP A . n 
A 1 440 TRP 440 703 703 TRP TRP A . n 
A 1 441 THR 441 704 704 THR THR A . n 
A 1 442 GLN 442 705 705 GLN GLN A . n 
A 1 443 VAL 443 706 706 VAL VAL A . n 
A 1 444 PRO 444 707 707 PRO PRO A . n 
A 1 445 PHE 445 708 708 PHE PHE A . n 
A 1 446 CYS 446 709 709 CYS CYS A . n 
A 1 447 SER 447 710 710 SER SER A . n 
A 1 448 HIS 448 711 711 HIS HIS A . n 
A 1 449 HIS 449 712 712 HIS HIS A . n 
A 1 450 PHE 450 713 713 PHE PHE A . n 
A 1 451 HIS 451 714 714 HIS HIS A . n 
A 1 452 GLU 452 715 715 GLU GLU A . n 
A 1 453 LEU 453 716 716 LEU LEU A . n 
A 1 454 ILE 454 717 717 ILE ILE A . n 
A 1 455 MET 455 718 718 MET MET A . n 
A 1 456 LYS 456 719 719 LYS LYS A . n 
A 1 457 ASP 457 720 720 ASP ASP A . n 
A 1 458 GLY 458 721 721 GLY GLY A . n 
A 1 459 ARG 459 722 722 ARG ARG A . n 
A 1 460 VAL 460 723 723 VAL VAL A . n 
A 1 461 LEU 461 724 724 LEU LEU A . n 
A 1 462 VAL 462 725 725 VAL VAL A . n 
A 1 463 VAL 463 726 726 VAL VAL A . n 
A 1 464 PRO 464 727 727 PRO PRO A . n 
A 1 465 CYS 465 728 728 CYS CYS A . n 
A 1 466 ARG 466 729 729 ARG ARG A . n 
A 1 467 ASN 467 730 730 ASN ASN A . n 
A 1 468 GLN 468 731 731 GLN GLN A . n 
A 1 469 ASP 469 732 732 ASP ASP A . n 
A 1 470 GLU 470 733 733 GLU GLU A . n 
A 1 471 LEU 471 734 734 LEU LEU A . n 
A 1 472 ILE 472 735 735 ILE ILE A . n 
A 1 473 GLY 473 736 736 GLY GLY A . n 
A 1 474 ARG 474 737 737 ARG ARG A . n 
A 1 475 ALA 475 738 738 ALA ALA A . n 
A 1 476 ARG 476 739 739 ARG ARG A . n 
A 1 477 ILE 477 740 740 ILE ILE A . n 
A 1 478 SER 478 741 741 SER SER A . n 
A 1 479 GLN 479 742 742 GLN GLN A . n 
A 1 480 GLY 480 743 743 GLY GLY A . n 
A 1 481 ALA 481 744 744 ALA ALA A . n 
A 1 482 GLY 482 745 745 GLY GLY A . n 
A 1 483 TRP 483 746 746 TRP TRP A . n 
A 1 484 SER 484 747 747 SER SER A . n 
A 1 485 LEU 485 748 748 LEU LEU A . n 
A 1 486 ARG 486 749 749 ARG ARG A . n 
A 1 487 GLU 487 750 750 GLU GLU A . n 
A 1 488 THR 488 751 751 THR THR A . n 
A 1 489 ALA 489 752 752 ALA ALA A . n 
A 1 490 CYS 490 753 753 CYS CYS A . n 
A 1 491 LEU 491 754 754 LEU LEU A . n 
A 1 492 GLY 492 755 755 GLY GLY A . n 
A 1 493 LYS 493 756 756 LYS LYS A . n 
A 1 494 SER 494 757 757 SER SER A . n 
A 1 495 TYR 495 758 758 TYR TYR A . n 
A 1 496 ALA 496 759 759 ALA ALA A . n 
A 1 497 GLN 497 760 760 GLN GLN A . n 
A 1 498 MET 498 761 761 MET MET A . n 
A 1 499 TRP 499 762 762 TRP TRP A . n 
A 1 500 SER 500 763 763 SER SER A . n 
A 1 501 LEU 501 764 764 LEU LEU A . n 
A 1 502 MET 502 765 765 MET MET A . n 
A 1 503 TYR 503 766 766 TYR TYR A . n 
A 1 504 PHE 504 767 767 PHE PHE A . n 
A 1 505 HIS 505 768 768 HIS HIS A . n 
A 1 506 ARG 506 769 769 ARG ARG A . n 
A 1 507 ARG 507 770 770 ARG ARG A . n 
A 1 508 ASP 508 771 771 ASP ASP A . n 
A 1 509 LEU 509 772 772 LEU LEU A . n 
A 1 510 ARG 510 773 773 ARG ARG A . n 
A 1 511 LEU 511 774 774 LEU LEU A . n 
A 1 512 ALA 512 775 775 ALA ALA A . n 
A 1 513 ALA 513 776 776 ALA ALA A . n 
A 1 514 ASN 514 777 777 ASN ASN A . n 
A 1 515 ALA 515 778 778 ALA ALA A . n 
A 1 516 ILE 516 779 779 ILE ILE A . n 
A 1 517 CYS 517 780 780 CYS CYS A . n 
A 1 518 SER 518 781 781 SER SER A . n 
A 1 519 ALA 519 782 782 ALA ALA A . n 
A 1 520 VAL 520 783 783 VAL VAL A . n 
A 1 521 PRO 521 784 784 PRO PRO A . n 
A 1 522 SER 522 785 785 SER SER A . n 
A 1 523 HIS 523 786 786 HIS HIS A . n 
A 1 524 TRP 524 787 787 TRP TRP A . n 
A 1 525 VAL 525 788 788 VAL VAL A . n 
A 1 526 PRO 526 789 789 PRO PRO A . n 
A 1 527 THR 527 790 790 THR THR A . n 
A 1 528 SER 528 791 ?   ?   ?   A . n 
A 1 529 ARG 529 792 ?   ?   ?   A . n 
A 1 530 THR 530 793 ?   ?   ?   A . n 
A 1 531 THR 531 794 ?   ?   ?   A . n 
A 1 532 TRP 532 795 ?   ?   ?   A . n 
A 1 533 SER 533 796 ?   ?   ?   A . n 
A 1 534 ILE 534 797 797 ILE ILE A . n 
A 1 535 HIS 535 798 798 HIS HIS A . n 
A 1 536 ALA 536 799 799 ALA ALA A . n 
A 1 537 THR 537 800 800 THR THR A . n 
A 1 538 HIS 538 801 801 HIS HIS A . n 
A 1 539 GLU 539 802 802 GLU GLU A . n 
A 1 540 TRP 540 803 803 TRP TRP A . n 
A 1 541 MET 541 804 804 MET MET A . n 
A 1 542 THR 542 805 805 THR THR A . n 
A 1 543 THR 543 806 806 THR THR A . n 
A 1 544 GLU 544 807 807 GLU GLU A . n 
A 1 545 ASP 545 808 808 ASP ASP A . n 
A 1 546 MET 546 809 809 MET MET A . n 
A 1 547 LEU 547 810 810 LEU LEU A . n 
A 1 548 THR 548 811 811 THR THR A . n 
A 1 549 VAL 549 812 812 VAL VAL A . n 
A 1 550 TRP 550 813 813 TRP TRP A . n 
A 1 551 ASN 551 814 814 ASN ASN A . n 
A 1 552 ARG 552 815 815 ARG ARG A . n 
A 1 553 VAL 553 816 816 VAL VAL A . n 
A 1 554 TRP 554 817 817 TRP TRP A . n 
A 1 555 ILE 555 818 818 ILE ILE A . n 
A 1 556 GLN 556 819 819 GLN GLN A . n 
A 1 557 GLU 557 820 820 GLU GLU A . n 
A 1 558 ASN 558 821 821 ASN ASN A . n 
A 1 559 PRO 559 822 822 PRO PRO A . n 
A 1 560 TRP 560 823 823 TRP TRP A . n 
A 1 561 MET 561 824 824 MET MET A . n 
A 1 562 GLU 562 825 825 GLU GLU A . n 
A 1 563 ASP 563 826 826 ASP ASP A . n 
A 1 564 LYS 564 827 827 LYS LYS A . n 
A 1 565 THR 565 828 828 THR THR A . n 
A 1 566 PRO 566 829 829 PRO PRO A . n 
A 1 567 VAL 567 830 830 VAL VAL A . n 
A 1 568 GLU 568 831 831 GLU GLU A . n 
A 1 569 SER 569 832 832 SER SER A . n 
A 1 570 TRP 570 833 833 TRP TRP A . n 
A 1 571 GLU 571 834 834 GLU GLU A . n 
A 1 572 GLU 572 835 835 GLU GLU A . n 
A 1 573 ILE 573 836 836 ILE ILE A . n 
A 1 574 PRO 574 837 837 PRO PRO A . n 
A 1 575 TYR 575 838 838 TYR TYR A . n 
A 1 576 LEU 576 839 839 LEU LEU A . n 
A 1 577 GLY 577 840 840 GLY GLY A . n 
A 1 578 LYS 578 841 841 LYS LYS A . n 
A 1 579 ARG 579 842 842 ARG ARG A . n 
A 1 580 GLU 580 843 843 GLU GLU A . n 
A 1 581 ASP 581 844 844 ASP ASP A . n 
A 1 582 GLN 582 845 845 GLN GLN A . n 
A 1 583 TRP 583 846 846 TRP TRP A . n 
A 1 584 CYS 584 847 847 CYS CYS A . n 
A 1 585 GLY 585 848 848 GLY GLY A . n 
A 1 586 SER 586 849 849 SER SER A . n 
A 1 587 LEU 587 850 850 LEU LEU A . n 
A 1 588 ILE 588 851 851 ILE ILE A . n 
A 1 589 GLY 589 852 852 GLY GLY A . n 
A 1 590 LEU 590 853 853 LEU LEU A . n 
A 1 591 THR 591 854 854 THR THR A . n 
A 1 592 SER 592 855 855 SER SER A . n 
A 1 593 ARG 593 856 856 ARG ARG A . n 
A 1 594 ALA 594 857 857 ALA ALA A . n 
A 1 595 THR 595 858 858 THR THR A . n 
A 1 596 TRP 596 859 859 TRP TRP A . n 
A 1 597 ALA 597 860 860 ALA ALA A . n 
A 1 598 LYS 598 861 861 LYS LYS A . n 
A 1 599 ASN 599 862 862 ASN ASN A . n 
A 1 600 ILE 600 863 863 ILE ILE A . n 
A 1 601 GLN 601 864 864 GLN GLN A . n 
A 1 602 THR 602 865 865 THR THR A . n 
A 1 603 ALA 603 866 866 ALA ALA A . n 
A 1 604 ILE 604 867 867 ILE ILE A . n 
A 1 605 ASN 605 868 868 ASN ASN A . n 
A 1 606 GLN 606 869 869 GLN GLN A . n 
A 1 607 VAL 607 870 870 VAL VAL A . n 
A 1 608 ARG 608 871 871 ARG ARG A . n 
A 1 609 SER 609 872 872 SER SER A . n 
A 1 610 LEU 610 873 873 LEU LEU A . n 
A 1 611 ILE 611 874 874 ILE ILE A . n 
A 1 612 GLY 612 875 875 GLY GLY A . n 
A 1 613 ASN 613 876 876 ASN ASN A . n 
A 1 614 GLU 614 877 877 GLU GLU A . n 
A 1 615 GLU 615 878 878 GLU GLU A . n 
A 1 616 TYR 616 879 879 TYR TYR A . n 
A 1 617 THR 617 880 880 THR THR A . n 
A 1 618 ASP 618 881 881 ASP ASP A . n 
A 1 619 TYR 619 882 882 TYR TYR A . n 
A 1 620 MET 620 883 883 MET MET A . n 
A 1 621 PRO 621 884 884 PRO PRO A . n 
A 1 622 SER 622 885 885 SER SER A . n 
A 1 623 MET 623 886 886 MET MET A . n 
A 1 624 LYS 624 887 887 LYS LYS A . n 
A 1 625 ARG 625 888 888 ARG ARG A . n 
A 1 626 PHE 626 889 889 PHE PHE A . n 
A 1 627 ARG 627 890 890 ARG ARG A . n 
A 1 628 ARG 628 891 891 ARG ARG A . n 
A 1 629 GLU 629 892 ?   ?   ?   A . n 
A 1 630 GLU 630 893 ?   ?   ?   A . n 
A 1 631 GLU 631 894 ?   ?   ?   A . n 
A 1 632 GLU 632 895 ?   ?   ?   A . n 
A 1 633 ALA 633 896 ?   ?   ?   A . n 
A 1 634 GLY 634 897 ?   ?   ?   A . n 
A 1 635 VAL 635 898 ?   ?   ?   A . n 
A 1 636 LEU 636 899 ?   ?   ?   A . n 
A 1 637 TRP 637 900 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        UWS 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   UWS 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 ZN  1   1001 1001 ZN  ZN  A . 
C 2 ZN  1   1002 1002 ZN  ZN  A . 
D 3 MES 1   1003 1004 MES MES A . 
E 4 DMS 1   1004 1530 DMS DMS A . 
F 4 DMS 1   1005 1601 DMS DMS A . 
G 5 PO4 1   1006 1604 PO4 PO4 A . 
H 5 PO4 1   1007 1606 PO4 PO4 A . 
I 6 PEG 1   1008 1607 PEG PEG A . 
J 7 CL  1   1009 2001 CL  CL  A . 
K 8 UWS 1   1010 2101 UWS LIG A . 
L 8 UWS 1   1011 2102 UWS LIG A . 
M 7 CL  1   1012 1    CL  CL  A . 
N 9 HOH 1   1101 341  HOH HOH A . 
N 9 HOH 2   1102 90   HOH HOH A . 
N 9 HOH 3   1103 254  HOH HOH A . 
N 9 HOH 4   1104 195  HOH HOH A . 
N 9 HOH 5   1105 259  HOH HOH A . 
N 9 HOH 6   1106 197  HOH HOH A . 
N 9 HOH 7   1107 416  HOH HOH A . 
N 9 HOH 8   1108 363  HOH HOH A . 
N 9 HOH 9   1109 209  HOH HOH A . 
N 9 HOH 10  1110 220  HOH HOH A . 
N 9 HOH 11  1111 243  HOH HOH A . 
N 9 HOH 12  1112 248  HOH HOH A . 
N 9 HOH 13  1113 76   HOH HOH A . 
N 9 HOH 14  1114 204  HOH HOH A . 
N 9 HOH 15  1115 189  HOH HOH A . 
N 9 HOH 16  1116 318  HOH HOH A . 
N 9 HOH 17  1117 266  HOH HOH A . 
N 9 HOH 18  1118 27   HOH HOH A . 
N 9 HOH 19  1119 152  HOH HOH A . 
N 9 HOH 20  1120 34   HOH HOH A . 
N 9 HOH 21  1121 247  HOH HOH A . 
N 9 HOH 22  1122 278  HOH HOH A . 
N 9 HOH 23  1123 348  HOH HOH A . 
N 9 HOH 24  1124 300  HOH HOH A . 
N 9 HOH 25  1125 217  HOH HOH A . 
N 9 HOH 26  1126 47   HOH HOH A . 
N 9 HOH 27  1127 185  HOH HOH A . 
N 9 HOH 28  1128 191  HOH HOH A . 
N 9 HOH 29  1129 312  HOH HOH A . 
N 9 HOH 30  1130 176  HOH HOH A . 
N 9 HOH 31  1131 179  HOH HOH A . 
N 9 HOH 32  1132 239  HOH HOH A . 
N 9 HOH 33  1133 58   HOH HOH A . 
N 9 HOH 34  1134 308  HOH HOH A . 
N 9 HOH 35  1135 184  HOH HOH A . 
N 9 HOH 36  1136 227  HOH HOH A . 
N 9 HOH 37  1137 225  HOH HOH A . 
N 9 HOH 38  1138 201  HOH HOH A . 
N 9 HOH 39  1139 292  HOH HOH A . 
N 9 HOH 40  1140 177  HOH HOH A . 
N 9 HOH 41  1141 151  HOH HOH A . 
N 9 HOH 42  1142 230  HOH HOH A . 
N 9 HOH 43  1143 376  HOH HOH A . 
N 9 HOH 44  1144 277  HOH HOH A . 
N 9 HOH 45  1145 236  HOH HOH A . 
N 9 HOH 46  1146 461  HOH HOH A . 
N 9 HOH 47  1147 222  HOH HOH A . 
N 9 HOH 48  1148 251  HOH HOH A . 
N 9 HOH 49  1149 224  HOH HOH A . 
N 9 HOH 50  1150 178  HOH HOH A . 
N 9 HOH 51  1151 345  HOH HOH A . 
N 9 HOH 52  1152 265  HOH HOH A . 
N 9 HOH 53  1153 346  HOH HOH A . 
N 9 HOH 54  1154 401  HOH HOH A . 
N 9 HOH 55  1155 107  HOH HOH A . 
N 9 HOH 56  1156 303  HOH HOH A . 
N 9 HOH 57  1157 250  HOH HOH A . 
N 9 HOH 58  1158 210  HOH HOH A . 
N 9 HOH 59  1159 333  HOH HOH A . 
N 9 HOH 60  1160 45   HOH HOH A . 
N 9 HOH 61  1161 186  HOH HOH A . 
N 9 HOH 62  1162 272  HOH HOH A . 
N 9 HOH 63  1163 268  HOH HOH A . 
N 9 HOH 64  1164 133  HOH HOH A . 
N 9 HOH 65  1165 187  HOH HOH A . 
N 9 HOH 66  1166 281  HOH HOH A . 
N 9 HOH 67  1167 289  HOH HOH A . 
N 9 HOH 68  1168 325  HOH HOH A . 
N 9 HOH 69  1169 196  HOH HOH A . 
N 9 HOH 70  1170 175  HOH HOH A . 
N 9 HOH 71  1171 2    HOH HOH A . 
N 9 HOH 72  1172 211  HOH HOH A . 
N 9 HOH 73  1173 190  HOH HOH A . 
N 9 HOH 74  1174 274  HOH HOH A . 
N 9 HOH 75  1175 238  HOH HOH A . 
N 9 HOH 76  1176 365  HOH HOH A . 
N 9 HOH 77  1177 273  HOH HOH A . 
N 9 HOH 78  1178 465  HOH HOH A . 
N 9 HOH 79  1179 202  HOH HOH A . 
N 9 HOH 80  1180 205  HOH HOH A . 
N 9 HOH 81  1181 216  HOH HOH A . 
N 9 HOH 82  1182 257  HOH HOH A . 
N 9 HOH 83  1183 306  HOH HOH A . 
N 9 HOH 84  1184 198  HOH HOH A . 
N 9 HOH 85  1185 258  HOH HOH A . 
N 9 HOH 86  1186 232  HOH HOH A . 
N 9 HOH 87  1187 215  HOH HOH A . 
N 9 HOH 88  1188 207  HOH HOH A . 
N 9 HOH 89  1189 269  HOH HOH A . 
N 9 HOH 90  1190 194  HOH HOH A . 
N 9 HOH 91  1191 244  HOH HOH A . 
N 9 HOH 92  1192 361  HOH HOH A . 
N 9 HOH 93  1193 294  HOH HOH A . 
N 9 HOH 94  1194 276  HOH HOH A . 
N 9 HOH 95  1195 234  HOH HOH A . 
N 9 HOH 96  1196 252  HOH HOH A . 
N 9 HOH 97  1197 240  HOH HOH A . 
N 9 HOH 98  1198 188  HOH HOH A . 
N 9 HOH 99  1199 285  HOH HOH A . 
N 9 HOH 100 1200 182  HOH HOH A . 
N 9 HOH 101 1201 262  HOH HOH A . 
N 9 HOH 102 1202 89   HOH HOH A . 
N 9 HOH 103 1203 83   HOH HOH A . 
N 9 HOH 104 1204 315  HOH HOH A . 
N 9 HOH 105 1205 231  HOH HOH A . 
N 9 HOH 106 1206 237  HOH HOH A . 
N 9 HOH 107 1207 16   HOH HOH A . 
N 9 HOH 108 1208 368  HOH HOH A . 
N 9 HOH 109 1209 219  HOH HOH A . 
N 9 HOH 110 1210 256  HOH HOH A . 
N 9 HOH 111 1211 270  HOH HOH A . 
N 9 HOH 112 1212 7    HOH HOH A . 
N 9 HOH 113 1213 309  HOH HOH A . 
N 9 HOH 114 1214 86   HOH HOH A . 
N 9 HOH 115 1215 199  HOH HOH A . 
N 9 HOH 116 1216 316  HOH HOH A . 
N 9 HOH 117 1217 355  HOH HOH A . 
N 9 HOH 118 1218 18   HOH HOH A . 
N 9 HOH 119 1219 255  HOH HOH A . 
N 9 HOH 120 1220 280  HOH HOH A . 
N 9 HOH 121 1221 298  HOH HOH A . 
N 9 HOH 122 1222 30   HOH HOH A . 
N 9 HOH 123 1223 423  HOH HOH A . 
N 9 HOH 124 1224 322  HOH HOH A . 
N 9 HOH 125 1225 467  HOH HOH A . 
N 9 HOH 126 1226 304  HOH HOH A . 
N 9 HOH 127 1227 389  HOH HOH A . 
N 9 HOH 128 1228 351  HOH HOH A . 
N 9 HOH 129 1229 320  HOH HOH A . 
N 9 HOH 130 1230 386  HOH HOH A . 
N 9 HOH 131 1231 260  HOH HOH A . 
N 9 HOH 132 1232 106  HOH HOH A . 
N 9 HOH 133 1233 241  HOH HOH A . 
N 9 HOH 134 1234 319  HOH HOH A . 
N 9 HOH 135 1235 305  HOH HOH A . 
N 9 HOH 136 1236 91   HOH HOH A . 
N 9 HOH 137 1237 82   HOH HOH A . 
N 9 HOH 138 1238 339  HOH HOH A . 
N 9 HOH 139 1239 233  HOH HOH A . 
N 9 HOH 140 1240 245  HOH HOH A . 
N 9 HOH 141 1241 331  HOH HOH A . 
N 9 HOH 142 1242 143  HOH HOH A . 
N 9 HOH 143 1243 314  HOH HOH A . 
N 9 HOH 144 1244 321  HOH HOH A . 
N 9 HOH 145 1245 279  HOH HOH A . 
N 9 HOH 146 1246 323  HOH HOH A . 
N 9 HOH 147 1247 367  HOH HOH A . 
N 9 HOH 148 1248 48   HOH HOH A . 
N 9 HOH 149 1249 372  HOH HOH A . 
N 9 HOH 150 1250 366  HOH HOH A . 
N 9 HOH 151 1251 350  HOH HOH A . 
N 9 HOH 152 1252 328  HOH HOH A . 
N 9 HOH 153 1253 377  HOH HOH A . 
N 9 HOH 154 1254 290  HOH HOH A . 
N 9 HOH 155 1255 284  HOH HOH A . 
N 9 HOH 156 1256 330  HOH HOH A . 
N 9 HOH 157 1257 261  HOH HOH A . 
N 9 HOH 158 1258 458  HOH HOH A . 
N 9 HOH 159 1259 39   HOH HOH A . 
N 9 HOH 160 1260 379  HOH HOH A . 
N 9 HOH 161 1261 391  HOH HOH A . 
N 9 HOH 162 1262 96   HOH HOH A . 
N 9 HOH 163 1263 148  HOH HOH A . 
N 9 HOH 164 1264 20   HOH HOH A . 
N 9 HOH 165 1265 67   HOH HOH A . 
N 9 HOH 166 1266 4    HOH HOH A . 
N 9 HOH 167 1267 5    HOH HOH A . 
N 9 HOH 168 1268 354  HOH HOH A . 
N 9 HOH 169 1269 313  HOH HOH A . 
N 9 HOH 170 1270 335  HOH HOH A . 
N 9 HOH 171 1271 357  HOH HOH A . 
N 9 HOH 172 1272 97   HOH HOH A . 
N 9 HOH 173 1273 349  HOH HOH A . 
N 9 HOH 174 1274 393  HOH HOH A . 
N 9 HOH 175 1275 374  HOH HOH A . 
N 9 HOH 176 1276 218  HOH HOH A . 
N 9 HOH 177 1277 422  HOH HOH A . 
N 9 HOH 178 1278 110  HOH HOH A . 
N 9 HOH 179 1279 282  HOH HOH A . 
N 9 HOH 180 1280 347  HOH HOH A . 
N 9 HOH 181 1281 295  HOH HOH A . 
N 9 HOH 182 1282 33   HOH HOH A . 
N 9 HOH 183 1283 15   HOH HOH A . 
N 9 HOH 184 1284 384  HOH HOH A . 
N 9 HOH 185 1285 413  HOH HOH A . 
N 9 HOH 186 1286 127  HOH HOH A . 
N 9 HOH 187 1287 369  HOH HOH A . 
N 9 HOH 188 1288 402  HOH HOH A . 
N 9 HOH 189 1289 399  HOH HOH A . 
N 9 HOH 190 1290 109  HOH HOH A . 
N 9 HOH 191 1291 287  HOH HOH A . 
N 9 HOH 192 1292 344  HOH HOH A . 
N 9 HOH 193 1293 371  HOH HOH A . 
N 9 HOH 194 1294 38   HOH HOH A . 
N 9 HOH 195 1295 381  HOH HOH A . 
N 9 HOH 196 1296 56   HOH HOH A . 
N 9 HOH 197 1297 310  HOH HOH A . 
N 9 HOH 198 1298 118  HOH HOH A . 
N 9 HOH 199 1299 32   HOH HOH A . 
N 9 HOH 200 1300 291  HOH HOH A . 
N 9 HOH 201 1301 433  HOH HOH A . 
N 9 HOH 202 1302 14   HOH HOH A . 
N 9 HOH 203 1303 297  HOH HOH A . 
N 9 HOH 204 1304 398  HOH HOH A . 
N 9 HOH 205 1305 352  HOH HOH A . 
N 9 HOH 206 1306 68   HOH HOH A . 
N 9 HOH 207 1307 392  HOH HOH A . 
N 9 HOH 208 1308 380  HOH HOH A . 
N 9 HOH 209 1309 99   HOH HOH A . 
N 9 HOH 210 1310 404  HOH HOH A . 
N 9 HOH 211 1311 403  HOH HOH A . 
N 9 HOH 212 1312 334  HOH HOH A . 
N 9 HOH 213 1313 338  HOH HOH A . 
N 9 HOH 214 1314 394  HOH HOH A . 
N 9 HOH 215 1315 466  HOH HOH A . 
N 9 HOH 216 1316 340  HOH HOH A . 
N 9 HOH 217 1317 360  HOH HOH A . 
N 9 HOH 218 1318 444  HOH HOH A . 
N 9 HOH 219 1319 342  HOH HOH A . 
N 9 HOH 220 1320 383  HOH HOH A . 
N 9 HOH 221 1321 378  HOH HOH A . 
N 9 HOH 222 1322 329  HOH HOH A . 
N 9 HOH 223 1323 411  HOH HOH A . 
N 9 HOH 224 1324 42   HOH HOH A . 
N 9 HOH 225 1325 406  HOH HOH A . 
N 9 HOH 226 1326 203  HOH HOH A . 
N 9 HOH 227 1327 337  HOH HOH A . 
N 9 HOH 228 1328 1    HOH HOH A . 
N 9 HOH 229 1329 246  HOH HOH A . 
N 9 HOH 230 1330 359  HOH HOH A . 
N 9 HOH 231 1331 462  HOH HOH A . 
N 9 HOH 232 1332 324  HOH HOH A . 
N 9 HOH 233 1333 235  HOH HOH A . 
N 9 HOH 234 1334 136  HOH HOH A . 
N 9 HOH 235 1335 459  HOH HOH A . 
N 9 HOH 236 1336 137  HOH HOH A . 
N 9 HOH 237 1337 40   HOH HOH A . 
N 9 HOH 238 1338 452  HOH HOH A . 
N 9 HOH 239 1339 114  HOH HOH A . 
N 9 HOH 240 1340 412  HOH HOH A . 
N 9 HOH 241 1341 92   HOH HOH A . 
N 9 HOH 242 1342 326  HOH HOH A . 
N 9 HOH 243 1343 390  HOH HOH A . 
N 9 HOH 244 1344 418  HOH HOH A . 
N 9 HOH 245 1345 427  HOH HOH A . 
N 9 HOH 246 1346 396  HOH HOH A . 
N 9 HOH 247 1347 253  HOH HOH A . 
N 9 HOH 248 1348 31   HOH HOH A . 
N 9 HOH 249 1349 373  HOH HOH A . 
N 9 HOH 250 1350 132  HOH HOH A . 
N 9 HOH 251 1351 62   HOH HOH A . 
N 9 HOH 252 1352 409  HOH HOH A . 
N 9 HOH 253 1353 60   HOH HOH A . 
N 9 HOH 254 1354 415  HOH HOH A . 
N 9 HOH 255 1355 353  HOH HOH A . 
N 9 HOH 256 1356 117  HOH HOH A . 
N 9 HOH 257 1357 464  HOH HOH A . 
N 9 HOH 258 1358 436  HOH HOH A . 
N 9 HOH 259 1359 75   HOH HOH A . 
N 9 HOH 260 1360 410  HOH HOH A . 
N 9 HOH 261 1361 364  HOH HOH A . 
N 9 HOH 262 1362 437  HOH HOH A . 
N 9 HOH 263 1363 439  HOH HOH A . 
N 9 HOH 264 1364 426  HOH HOH A . 
N 9 HOH 265 1365 434  HOH HOH A . 
N 9 HOH 266 1366 430  HOH HOH A . 
N 9 HOH 267 1367 159  HOH HOH A . 
N 9 HOH 268 1368 414  HOH HOH A . 
N 9 HOH 269 1369 332  HOH HOH A . 
N 9 HOH 270 1370 424  HOH HOH A . 
N 9 HOH 271 1371 438  HOH HOH A . 
N 9 HOH 272 1372 299  HOH HOH A . 
N 9 HOH 273 1373 429  HOH HOH A . 
N 9 HOH 274 1374 112  HOH HOH A . 
N 9 HOH 275 1375 154  HOH HOH A . 
N 9 HOH 276 1376 163  HOH HOH A . 
N 9 HOH 277 1377 6    HOH HOH A . 
N 9 HOH 278 1378 428  HOH HOH A . 
N 9 HOH 279 1379 417  HOH HOH A . 
N 9 HOH 280 1380 431  HOH HOH A . 
N 9 HOH 281 1381 41   HOH HOH A . 
N 9 HOH 282 1382 88   HOH HOH A . 
N 9 HOH 283 1383 78   HOH HOH A . 
N 9 HOH 284 1384 63   HOH HOH A . 
N 9 HOH 285 1385 435  HOH HOH A . 
N 9 HOH 286 1386 123  HOH HOH A . 
N 9 HOH 287 1387 301  HOH HOH A . 
N 9 HOH 288 1388 425  HOH HOH A . 
N 9 HOH 289 1389 126  HOH HOH A . 
N 9 HOH 290 1390 443  HOH HOH A . 
N 9 HOH 291 1391 61   HOH HOH A . 
N 9 HOH 292 1392 397  HOH HOH A . 
N 9 HOH 293 1393 131  HOH HOH A . 
N 9 HOH 294 1394 8    HOH HOH A . 
N 9 HOH 295 1395 445  HOH HOH A . 
N 9 HOH 296 1396 441  HOH HOH A . 
N 9 HOH 297 1397 447  HOH HOH A . 
N 9 HOH 298 1398 171  HOH HOH A . 
N 9 HOH 299 1399 135  HOH HOH A . 
N 9 HOH 300 1400 456  HOH HOH A . 
N 9 HOH 301 1401 9    HOH HOH A . 
N 9 HOH 302 1402 440  HOH HOH A . 
N 9 HOH 303 1403 95   HOH HOH A . 
N 9 HOH 304 1404 122  HOH HOH A . 
N 9 HOH 305 1405 450  HOH HOH A . 
N 9 HOH 306 1406 200  HOH HOH A . 
N 9 HOH 307 1407 73   HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A THR 344 ? CB  ? A THR 81 CB  
2 1 Y 1 A THR 344 ? OG1 ? A THR 81 OG1 
3 1 Y 1 A THR 344 ? CG2 ? A THR 81 CG2 
# 
loop_
_software.classification 
_software.name 
_software.version 
_software.citation_id 
_software.pdbx_ordinal 
_software.date 
_software.type 
_software.location 
_software.language 
refinement       REFMAC  5.8.0267 ? 1 ? ? ? ? 
'data scaling'   Aimless .        ? 2 ? ? ? ? 
phasing          PHASER  .        ? 3 ? ? ? ? 
'data reduction' XDS     .        ? 4 ? ? ? ? 
# 
_cell.entry_id           7I2G 
_cell.length_a           82.422 
_cell.length_b           116.041 
_cell.length_c           147.388 
_cell.angle_alpha        90.00 
_cell.angle_beta         90.00 
_cell.angle_gamma        90.00 
_cell.Z_PDB              8 
_cell.pdbx_unique_axis   ? 
# 
_symmetry.entry_id                         7I2G 
_symmetry.space_group_name_H-M             'I 2 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                23 
# 
_exptl.entry_id          7I2G 
_exptl.method            'X-RAY DIFFRACTION' 
_exptl.crystals_number   1 
# 
_exptl_crystal.id                    1 
_exptl_crystal.density_meas          ? 
_exptl_crystal.density_Matthews      2.38 
_exptl_crystal.density_percent_sol   48.42 
_exptl_crystal.description           ? 
_exptl_crystal.preparation           ? 
# 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.temp            293.15 
_exptl_crystal_grow.pdbx_details    '350 mM Magnesium chloride, 10% PEG 4000, 100 mM MES, pH 6.5' 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.pdbx_pH_range   ? 
# 
_diffrn.id                               1 
_diffrn.ambient_temp                     100 
_diffrn.crystal_id                       1 
_diffrn.ambient_temp_details             ? 
_diffrn.pdbx_serial_crystal_experiment   ? 
# 
_diffrn_detector.detector               PIXEL 
_diffrn_detector.type                   'DECTRIS EIGER2 XE 9M' 
_diffrn_detector.pdbx_collection_date   2023-12-03 
_diffrn_detector.diffrn_id              1 
_diffrn_detector.details                ? 
# 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.92124 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.diffrn_id                   1 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.type                        'DIAMOND BEAMLINE I04-1' 
_diffrn_source.pdbx_wavelength_list        0.92124 
_diffrn_source.pdbx_synchrotron_site       Diamond 
_diffrn_source.pdbx_synchrotron_beamline   I04-1 
_diffrn_source.pdbx_wavelength             ? 
# 
_reflns.entry_id                     7I2G 
_reflns.pdbx_diffrn_id               1 
_reflns.pdbx_ordinal                 1 
_reflns.d_resolution_low             73.69 
_reflns.d_resolution_high            1.85 
_reflns.number_obs                   60472 
_reflns.percent_possible_obs         99.9 
_reflns.pdbx_Rmerge_I_obs            0.213 
_reflns.pdbx_netI_over_sigmaI        7.8 
_reflns.pdbx_redundancy              13.7 
_reflns.pdbx_Rrim_I_all              0.221 
_reflns.pdbx_Rpim_I_all              0.059 
_reflns.pdbx_CC_half                 0.998 
_reflns.pdbx_number_measured_all     830374 
_reflns.pdbx_chi_squared             0.42 
_reflns.observed_criterion_sigma_I   ? 
_reflns.observed_criterion_sigma_F   ? 
_reflns.number_all                   ? 
_reflns.pdbx_Rsym_value              ? 
_reflns.B_iso_Wilson_estimate        ? 
_reflns.pdbx_CC_star                 ? 
# 
_reflns_shell.pdbx_diffrn_id              1 
_reflns_shell.pdbx_ordinal                1 
_reflns_shell.d_res_high                  1.85 
_reflns_shell.d_res_low                   1.89 
_reflns_shell.number_measured_all         51028 
_reflns_shell.number_unique_obs           3664 
_reflns_shell.Rmerge_I_obs                6.127 
_reflns_shell.pdbx_chi_squared            0.21 
_reflns_shell.pdbx_redundancy             13.9 
_reflns_shell.percent_possible_obs        99.0 
_reflns_shell.pdbx_netI_over_sigmaI_obs   0.2 
_reflns_shell.pdbx_Rrim_I_all             6.360 
_reflns_shell.pdbx_Rpim_I_all             1.699 
_reflns_shell.pdbx_CC_half                0.329 
_reflns_shell.percent_possible_all        ? 
_reflns_shell.pdbx_Rsym_value             ? 
_reflns_shell.meanI_over_sigI_obs         ? 
_reflns_shell.number_measured_obs         ? 
_reflns_shell.number_unique_all           ? 
_reflns_shell.pdbx_CC_star                ? 
# 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.entry_id                                 7I2G 
_refine.pdbx_diffrn_id                           1 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     56225 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             73.69 
_refine.ls_d_res_high                            1.85 
_refine.ls_percent_reflns_obs                    98.03 
_refine.ls_R_factor_obs                          0.20889 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       0.20677 
_refine.ls_R_factor_R_free                       0.24669 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 5.2 
_refine.ls_number_reflns_R_free                  3076 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               0.961 
_refine.correlation_coeff_Fo_to_Fc_free          0.950 
_refine.B_iso_mean                               59.649 
_refine.aniso_B[1][1]                            -2.87 
_refine.aniso_B[2][2]                            0.16 
_refine.aniso_B[3][3]                            2.71 
_refine.aniso_B[1][2]                            -0.00 
_refine.aniso_B[1][3]                            0.00 
_refine.aniso_B[2][3]                            -0.00 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_overall_ESU_R                       0.347 
_refine.pdbx_overall_ESU_R_Free                  0.204 
_refine.overall_SU_ML                            0.298 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             12.096 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.pdbx_number_atoms_protein        4660 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         71 
_refine_hist.number_atoms_solvent             307 
_refine_hist.number_atoms_total               5038 
_refine_hist.d_res_high                       1.85 
_refine_hist.d_res_low                        73.69 
# 
loop_
_refine_ls_restr.type 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.weight 
_refine_ls_restr.number 
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.pdbx_restraint_function 
r_bond_refined_d             0.005  0.015  ? 14205 'X-RAY DIFFRACTION' ? 
r_bond_other_d               0.001  0.015  ? 9633  'X-RAY DIFFRACTION' ? 
r_angle_refined_deg          1.299  1.639  ? 14233 'X-RAY DIFFRACTION' ? 
r_angle_other_deg            1.162  1.597  ? 22325 'X-RAY DIFFRACTION' ? 
r_dihedral_angle_1_deg       5.719  5.000  ? 1351  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_2_deg       29.635 21.482 ? 614   'X-RAY DIFFRACTION' ? 
r_dihedral_angle_3_deg       15.910 15.000 ? 1929  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_4_deg       17.383 15.000 ? 94    'X-RAY DIFFRACTION' ? 
r_chiral_restr               0.055  0.200  ? 1259  'X-RAY DIFFRACTION' ? 
r_gen_planes_refined         0.005  0.020  ? 12730 'X-RAY DIFFRACTION' ? 
r_gen_planes_other           0.001  0.020  ? 2650  'X-RAY DIFFRACTION' ? 
r_nbd_refined                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbd_other                  ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_refined              ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_other                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_refined        ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_other          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_refined          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_other            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_refined       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_other         ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_refined     ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_other       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_refined ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_other   ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_mcbond_it                  2.473  5.920  ? 6806  'X-RAY DIFFRACTION' ? 
r_mcbond_other               2.512  5.952  ? 6598  'X-RAY DIFFRACTION' ? 
r_mcangle_it                 4.623  8.638  ? 6425  'X-RAY DIFFRACTION' ? 
r_mcangle_other              4.623  8.638  ? 6422  'X-RAY DIFFRACTION' ? 
r_scbond_it                  2.757  6.655  ? 7399  'X-RAY DIFFRACTION' ? 
r_scbond_other               2.757  6.655  ? 7400  'X-RAY DIFFRACTION' ? 
r_scangle_it                 ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_scangle_other              4.966  9.627  ? 7809  'X-RAY DIFFRACTION' ? 
r_long_range_B_refined       8.203  50.716 ? 10193 'X-RAY DIFFRACTION' ? 
r_long_range_B_other         8.084  50.363 ? 10034 'X-RAY DIFFRACTION' ? 
r_rigid_bond_restr           ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_free            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_bonded          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.d_res_high                       1.851 
_refine_ls_shell.d_res_low                        1.899 
_refine_ls_shell.number_reflns_R_work             3193 
_refine_ls_shell.R_factor_R_work                  0.487 
_refine_ls_shell.percent_reflns_obs               76.19 
_refine_ls_shell.R_factor_R_free                  0.483 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.number_reflns_R_free             195 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.number_reflns_obs                ? 
# 
_struct.entry_id                  7I2G 
_struct.title                     
;Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z1079512010 (DNV2_NS5A-x0379)
;
_struct.pdbx_model_details        ? 
_struct.pdbx_CASP_flag            ? 
_struct.pdbx_model_type_details   ? 
# 
_struct_keywords.entry_id        7I2G 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
_struct_keywords.text            
;Diamond Light Source, I04-1, READDI, Dengue Virus, crystallographic fragment screening, PanDDA, XChemExplorer, cluster4x, VIRAL PROTEIN
;
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 5 ? 
H N N 5 ? 
I N N 6 ? 
J N N 7 ? 
K N N 8 ? 
L N N 8 ? 
M N N 7 ? 
N N N 9 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q91H74_9FLAV 
_struct_ref.pdbx_db_accession          Q91H74 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;GIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAMTD
TTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAREA
VEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLS
GVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRPTP
RGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGDDC
VVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQGAG
WSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPWME
DKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_struct_ref.pdbx_align_begin           2757 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              7I2G 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 3 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 637 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q91H74 
_struct_ref_seq.db_align_beg                  2757 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3391 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       266 
_struct_ref_seq.pdbx_auth_seq_align_end       900 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 7I2G GLY A 1 ? UNP Q91H74 ? ? 'expression tag' 264 1 
1 7I2G PRO A 2 ? UNP Q91H74 ? ? 'expression tag' 265 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M,N 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 10  ? HIS A 25  ? ASN A 273 HIS A 288 1 ? 16 
HELX_P HELX_P2  AA2 ASN A 59  ? LEU A 65  ? ASN A 322 LEU A 328 1 ? 7  
HELX_P HELX_P3  AA3 THR A 66  ? ILE A 71  ? THR A 329 ILE A 334 5 ? 6  
HELX_P HELX_P4  AA4 ILE A 72  ? GLN A 77  ? ILE A 335 GLN A 340 1 ? 6  
HELX_P HELX_P5  AA5 MET A 78  ? MET A 80  ? MET A 341 MET A 343 5 ? 3  
HELX_P HELX_P6  AA6 LYS A 104 ? LYS A 124 ? LYS A 367 LYS A 387 1 ? 21 
HELX_P HELX_P7  AA7 THR A 132 ? ASN A 143 ? THR A 395 ASN A 406 1 ? 12 
HELX_P HELX_P8  AA8 SER A 158 ? ASP A 165 ? SER A 421 ASP A 428 1 ? 8  
HELX_P HELX_P9  AA9 ASP A 165 ? GLU A 181 ? ASP A 428 GLU A 444 1 ? 17 
HELX_P HELX_P10 AB1 LEU A 216 ? GLY A 227 ? LEU A 479 GLY A 490 1 ? 12 
HELX_P HELX_P11 AB2 GLY A 227 ? ASP A 232 ? GLY A 490 ASP A 495 1 ? 6  
HELX_P HELX_P12 AB3 SER A 236 ? LEU A 241 ? SER A 499 LEU A 504 1 ? 6  
HELX_P HELX_P13 AB4 GLY A 248 ? LYS A 261 ? GLY A 511 LYS A 524 1 ? 14 
HELX_P HELX_P14 AB5 TRP A 275 ? ILE A 279 ? TRP A 538 ILE A 542 5 ? 5  
HELX_P HELX_P15 AB6 THR A 280 ? GLU A 288 ? THR A 543 GLU A 551 1 ? 9  
HELX_P HELX_P16 AB7 MET A 289 ? MET A 294 ? MET A 552 MET A 557 5 ? 6  
HELX_P HELX_P17 AB8 GLU A 295 ? THR A 309 ? GLU A 558 THR A 572 1 ? 15 
HELX_P HELX_P18 AB9 GLY A 339 ? GLU A 363 ? GLY A 602 GLU A 626 1 ? 25 
HELX_P HELX_P19 AC1 THR A 373 ? SER A 393 ? THR A 636 SER A 656 1 ? 21 
HELX_P HELX_P20 AC2 ASP A 408 ? ALA A 414 ? ASP A 671 ALA A 677 5 ? 7  
HELX_P HELX_P21 AC3 LEU A 415 ? MET A 421 ? LEU A 678 MET A 684 1 ? 7  
HELX_P HELX_P22 AC4 ASP A 439 ? VAL A 443 ? ASP A 702 VAL A 706 5 ? 5  
HELX_P HELX_P23 AC5 ASN A 467 ? ARG A 476 ? ASN A 730 ARG A 739 1 ? 10 
HELX_P HELX_P24 AC6 SER A 484 ? TYR A 503 ? SER A 747 TYR A 766 1 ? 20 
HELX_P HELX_P25 AC7 ARG A 506 ? VAL A 520 ? ARG A 769 VAL A 783 1 ? 15 
HELX_P HELX_P26 AC8 ASP A 545 ? ILE A 555 ? ASP A 808 ILE A 818 1 ? 11 
HELX_P HELX_P27 AC9 SER A 569 ? ILE A 573 ? SER A 832 ILE A 836 5 ? 5  
HELX_P HELX_P28 AD1 GLY A 577 ? CYS A 584 ? GLY A 840 CYS A 847 1 ? 8  
HELX_P HELX_P29 AD2 LEU A 590 ? ASN A 599 ? LEU A 853 ASN A 862 1 ? 10 
HELX_P HELX_P30 AD3 ASN A 599 ? GLY A 612 ? ASN A 862 GLY A 875 1 ? 14 
HELX_P HELX_P31 AD4 TYR A 619 ? ARG A 627 ? TYR A 882 ARG A 890 5 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A GLU 175 OE1 ? ? ? 1_555 C ZN . ZN ? ? A GLU 438 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.128 ? ? 
metalc2 metalc ? ? A HIS 179 NE2 ? ? ? 1_555 C ZN . ZN ? ? A HIS 442 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.183 ? ? 
metalc3 metalc ? ? A CYS 184 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 447 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.207 ? ? 
metalc4 metalc ? ? A CYS 187 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 450 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.225 ? ? 
metalc5 metalc ? ? A HIS 449 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 712 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.034 ? ? 
metalc6 metalc ? ? A HIS 451 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 714 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.003 ? ? 
metalc7 metalc ? ? A CYS 465 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 728 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.395 ? ? 
metalc8 metalc ? ? A CYS 584 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 847 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.348 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 NE2 ? A HIS 179 ? A HIS 442 ? 1_555 87.3  ? 
2  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 139.4 ? 
3  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 120.1 ? 
4  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 80.3  ? 
5  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 110.8 ? 
6  SG  ? A CYS 184 ? A CYS 447 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 112.0 ? 
7  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 101.3 ? 
8  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 106.0 ? 
9  NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 106.1 ? 
10 NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 104.8 ? 
11 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 119.0 ? 
12 SG  ? A CYS 465 ? A CYS 728 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 117.6 ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 4 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
AA5 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA2 1 2 ? anti-parallel 
AA3 1 2 ? parallel      
AA4 1 2 ? anti-parallel 
AA5 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 41  ? TYR A 42  ? ALA A 304 TYR A 305 
AA1 2 VAL A 326 ? SER A 331 ? VAL A 589 SER A 594 
AA1 3 VAL A 315 ? ARG A 319 ? VAL A 578 ARG A 582 
AA1 4 TYR A 189 ? ASN A 190 ? TYR A 452 ASN A 453 
AA2 1 SER A 56  ? VAL A 58  ? SER A 319 VAL A 321 
AA2 2 ILE A 477 ? GLN A 479 ? ILE A 740 GLN A 742 
AA3 1 ALA A 148 ? ILE A 149 ? ALA A 411 ILE A 412 
AA3 2 MET A 214 ? TRP A 215 ? MET A 477 TRP A 478 
AA4 1 MET A 395 ? SER A 398 ? MET A 658 SER A 661 
AA4 2 ASP A 401 ? VAL A 404 ? ASP A 664 VAL A 667 
AA5 1 HIS A 449 ? ILE A 454 ? HIS A 712 ILE A 717 
AA5 2 VAL A 460 ? CYS A 465 ? VAL A 723 CYS A 728 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ALA A 41  ? N ALA A 304 O SER A 331 ? O SER A 594 
AA1 2 3 O ILE A 330 ? O ILE A 593 N VAL A 315 ? N VAL A 578 
AA1 3 4 O ARG A 316 ? O ARG A 579 N TYR A 189 ? N TYR A 452 
AA2 1 2 N MET A 57  ? N MET A 320 O SER A 478 ? O SER A 741 
AA3 1 2 N ILE A 149 ? N ILE A 412 O MET A 214 ? O MET A 477 
AA4 1 2 N SER A 398 ? N SER A 661 O ASP A 401 ? O ASP A 664 
AA5 1 2 N LEU A 453 ? N LEU A 716 O LEU A 461 ? O LEU A 724 
# 
_pdbx_entry_details.entry_id                   7I2G 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 O   A HOH 1255 ? ? O  A HOH 1360 ? ? 1.97 
2 1 OD1 A ASP 664  ? ? O4 A PO4 1006 ? ? 2.00 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    HOH 
_pdbx_validate_symm_contact.auth_seq_id_1     1313 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    A 
_pdbx_validate_symm_contact.auth_comp_id_2    HOH 
_pdbx_validate_symm_contact.auth_seq_id_2     1313 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   4_545 
_pdbx_validate_symm_contact.dist              2.19 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 ASP A 360 ? ? -96.07  53.74  
2 1 ASN A 406 ? ? 65.87   115.79 
3 1 LYS A 420 ? ? -50.86  -79.58 
4 1 LEU A 504 ? ? 71.29   -33.22 
5 1 ASN A 575 ? ? -151.24 76.64  
6 1 GLN A 598 ? ? 72.85   166.19 
7 1 THR A 800 ? ? -145.66 -9.19  
8 1 ASN A 862 ? ? -98.55  38.71  
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A MES 1003 ? D MES . 
2 1 A HOH 1172 ? N HOH . 
3 1 A HOH 1205 ? N HOH . 
4 1 A HOH 1369 ? N HOH . 
5 1 A HOH 1371 ? N HOH . 
# 
_pdbx_distant_solvent_atoms.id                                1 
_pdbx_distant_solvent_atoms.PDB_model_num                     1 
_pdbx_distant_solvent_atoms.auth_atom_id                      O 
_pdbx_distant_solvent_atoms.label_alt_id                      ? 
_pdbx_distant_solvent_atoms.auth_asym_id                      A 
_pdbx_distant_solvent_atoms.auth_comp_id                      HOH 
_pdbx_distant_solvent_atoms.auth_seq_id                       1407 
_pdbx_distant_solvent_atoms.PDB_ins_code                      ? 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance   6.28 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance          . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 264 ? A GLY 1   
2  1 Y 1 A PRO 265 ? A PRO 2   
3  1 Y 1 A GLY 266 ? A GLY 3   
4  1 Y 1 A ILE 267 ? A ILE 4   
5  1 Y 1 A GLU 268 ? A GLU 5   
6  1 Y 1 A SER 269 ? A SER 6   
7  1 Y 1 A GLU 270 ? A GLU 7   
8  1 Y 1 A THR 271 ? A THR 8   
9  1 Y 1 A PRO 272 ? A PRO 9   
10 1 Y 1 A LYS 312 ? A LYS 49  
11 1 Y 1 A GLN 313 ? A GLN 50  
12 1 Y 1 A THR 314 ? A THR 51  
13 1 Y 1 A GLY 315 ? A GLY 52  
14 1 Y 1 A SER 316 ? A SER 53  
15 1 Y 1 A ASP 345 ? A ASP 82  
16 1 Y 1 A THR 346 ? A THR 83  
17 1 Y 1 A THR 347 ? A THR 84  
18 1 Y 1 A PRO 348 ? A PRO 85  
19 1 Y 1 A PHE 349 ? A PHE 86  
20 1 Y 1 A GLY 350 ? A GLY 87  
21 1 Y 1 A GLN 351 ? A GLN 88  
22 1 Y 1 A GLN 352 ? A GLN 89  
23 1 Y 1 A ARG 353 ? A ARG 90  
24 1 Y 1 A VAL 354 ? A VAL 91  
25 1 Y 1 A PHE 355 ? A PHE 92  
26 1 Y 1 A LYS 356 ? A LYS 93  
27 1 Y 1 A PHE 413 ? A PHE 150 
28 1 Y 1 A THR 414 ? A THR 151 
29 1 Y 1 A ASP 415 ? A ASP 152 
30 1 Y 1 A GLU 416 ? A GLU 153 
31 1 Y 1 A ASN 417 ? A ASN 154 
32 1 Y 1 A GLY 456 ? A GLY 193 
33 1 Y 1 A LYS 457 ? A LYS 194 
34 1 Y 1 A ARG 458 ? A ARG 195 
35 1 Y 1 A GLU 459 ? A GLU 196 
36 1 Y 1 A LYS 460 ? A LYS 197 
37 1 Y 1 A LYS 461 ? A LYS 198 
38 1 Y 1 A LEU 462 ? A LEU 199 
39 1 Y 1 A GLY 463 ? A GLY 200 
40 1 Y 1 A GLU 464 ? A GLU 201 
41 1 Y 1 A PHE 465 ? A PHE 202 
42 1 Y 1 A GLY 466 ? A GLY 203 
43 1 Y 1 A LYS 467 ? A LYS 204 
44 1 Y 1 A ALA 468 ? A ALA 205 
45 1 Y 1 A LYS 469 ? A LYS 206 
46 1 Y 1 A GLY 470 ? A GLY 207 
47 1 Y 1 A SER 471 ? A SER 208 
48 1 Y 1 A ARG 472 ? A ARG 209 
49 1 Y 1 A ALA 473 ? A ALA 210 
50 1 Y 1 A PRO 585 ? A PRO 322 
51 1 Y 1 A ARG 586 ? A ARG 323 
52 1 Y 1 A GLY 587 ? A GLY 324 
53 1 Y 1 A SER 791 ? A SER 528 
54 1 Y 1 A ARG 792 ? A ARG 529 
55 1 Y 1 A THR 793 ? A THR 530 
56 1 Y 1 A THR 794 ? A THR 531 
57 1 Y 1 A TRP 795 ? A TRP 532 
58 1 Y 1 A SER 796 ? A SER 533 
59 1 Y 1 A GLU 892 ? A GLU 629 
60 1 Y 1 A GLU 893 ? A GLU 630 
61 1 Y 1 A GLU 894 ? A GLU 631 
62 1 Y 1 A GLU 895 ? A GLU 632 
63 1 Y 1 A ALA 896 ? A ALA 633 
64 1 Y 1 A GLY 897 ? A GLY 634 
65 1 Y 1 A VAL 898 ? A VAL 635 
66 1 Y 1 A LEU 899 ? A LEU 636 
67 1 Y 1 A TRP 900 ? A TRP 637 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CL  CL   CL N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
DMS S    S  N N 89  
DMS O    O  N N 90  
DMS C1   C  N N 91  
DMS C2   C  N N 92  
DMS H11  H  N N 93  
DMS H12  H  N N 94  
DMS H13  H  N N 95  
DMS H21  H  N N 96  
DMS H22  H  N N 97  
DMS H23  H  N N 98  
GLN N    N  N N 99  
GLN CA   C  N S 100 
GLN C    C  N N 101 
GLN O    O  N N 102 
GLN CB   C  N N 103 
GLN CG   C  N N 104 
GLN CD   C  N N 105 
GLN OE1  O  N N 106 
GLN NE2  N  N N 107 
GLN OXT  O  N N 108 
GLN H    H  N N 109 
GLN H2   H  N N 110 
GLN HA   H  N N 111 
GLN HB2  H  N N 112 
GLN HB3  H  N N 113 
GLN HG2  H  N N 114 
GLN HG3  H  N N 115 
GLN HE21 H  N N 116 
GLN HE22 H  N N 117 
GLN HXT  H  N N 118 
GLU N    N  N N 119 
GLU CA   C  N S 120 
GLU C    C  N N 121 
GLU O    O  N N 122 
GLU CB   C  N N 123 
GLU CG   C  N N 124 
GLU CD   C  N N 125 
GLU OE1  O  N N 126 
GLU OE2  O  N N 127 
GLU OXT  O  N N 128 
GLU H    H  N N 129 
GLU H2   H  N N 130 
GLU HA   H  N N 131 
GLU HB2  H  N N 132 
GLU HB3  H  N N 133 
GLU HG2  H  N N 134 
GLU HG3  H  N N 135 
GLU HE2  H  N N 136 
GLU HXT  H  N N 137 
GLY N    N  N N 138 
GLY CA   C  N N 139 
GLY C    C  N N 140 
GLY O    O  N N 141 
GLY OXT  O  N N 142 
GLY H    H  N N 143 
GLY H2   H  N N 144 
GLY HA2  H  N N 145 
GLY HA3  H  N N 146 
GLY HXT  H  N N 147 
HIS N    N  N N 148 
HIS CA   C  N S 149 
HIS C    C  N N 150 
HIS O    O  N N 151 
HIS CB   C  N N 152 
HIS CG   C  Y N 153 
HIS ND1  N  Y N 154 
HIS CD2  C  Y N 155 
HIS CE1  C  Y N 156 
HIS NE2  N  Y N 157 
HIS OXT  O  N N 158 
HIS H    H  N N 159 
HIS H2   H  N N 160 
HIS HA   H  N N 161 
HIS HB2  H  N N 162 
HIS HB3  H  N N 163 
HIS HD1  H  N N 164 
HIS HD2  H  N N 165 
HIS HE1  H  N N 166 
HIS HE2  H  N N 167 
HIS HXT  H  N N 168 
HOH O    O  N N 169 
HOH H1   H  N N 170 
HOH H2   H  N N 171 
ILE N    N  N N 172 
ILE CA   C  N S 173 
ILE C    C  N N 174 
ILE O    O  N N 175 
ILE CB   C  N S 176 
ILE CG1  C  N N 177 
ILE CG2  C  N N 178 
ILE CD1  C  N N 179 
ILE OXT  O  N N 180 
ILE H    H  N N 181 
ILE H2   H  N N 182 
ILE HA   H  N N 183 
ILE HB   H  N N 184 
ILE HG12 H  N N 185 
ILE HG13 H  N N 186 
ILE HG21 H  N N 187 
ILE HG22 H  N N 188 
ILE HG23 H  N N 189 
ILE HD11 H  N N 190 
ILE HD12 H  N N 191 
ILE HD13 H  N N 192 
ILE HXT  H  N N 193 
LEU N    N  N N 194 
LEU CA   C  N S 195 
LEU C    C  N N 196 
LEU O    O  N N 197 
LEU CB   C  N N 198 
LEU CG   C  N N 199 
LEU CD1  C  N N 200 
LEU CD2  C  N N 201 
LEU OXT  O  N N 202 
LEU H    H  N N 203 
LEU H2   H  N N 204 
LEU HA   H  N N 205 
LEU HB2  H  N N 206 
LEU HB3  H  N N 207 
LEU HG   H  N N 208 
LEU HD11 H  N N 209 
LEU HD12 H  N N 210 
LEU HD13 H  N N 211 
LEU HD21 H  N N 212 
LEU HD22 H  N N 213 
LEU HD23 H  N N 214 
LEU HXT  H  N N 215 
LYS N    N  N N 216 
LYS CA   C  N S 217 
LYS C    C  N N 218 
LYS O    O  N N 219 
LYS CB   C  N N 220 
LYS CG   C  N N 221 
LYS CD   C  N N 222 
LYS CE   C  N N 223 
LYS NZ   N  N N 224 
LYS OXT  O  N N 225 
LYS H    H  N N 226 
LYS H2   H  N N 227 
LYS HA   H  N N 228 
LYS HB2  H  N N 229 
LYS HB3  H  N N 230 
LYS HG2  H  N N 231 
LYS HG3  H  N N 232 
LYS HD2  H  N N 233 
LYS HD3  H  N N 234 
LYS HE2  H  N N 235 
LYS HE3  H  N N 236 
LYS HZ1  H  N N 237 
LYS HZ2  H  N N 238 
LYS HZ3  H  N N 239 
LYS HXT  H  N N 240 
MES O1   O  N N 241 
MES C2   C  N N 242 
MES C3   C  N N 243 
MES N4   N  N N 244 
MES C5   C  N N 245 
MES C6   C  N N 246 
MES C7   C  N N 247 
MES C8   C  N N 248 
MES S    S  N N 249 
MES O1S  O  N N 250 
MES O2S  O  N N 251 
MES O3S  O  N N 252 
MES H21  H  N N 253 
MES H22  H  N N 254 
MES H31  H  N N 255 
MES H32  H  N N 256 
MES HN4  H  N N 257 
MES H51  H  N N 258 
MES H52  H  N N 259 
MES H61  H  N N 260 
MES H62  H  N N 261 
MES H71  H  N N 262 
MES H72  H  N N 263 
MES H81  H  N N 264 
MES H82  H  N N 265 
MET N    N  N N 266 
MET CA   C  N S 267 
MET C    C  N N 268 
MET O    O  N N 269 
MET CB   C  N N 270 
MET CG   C  N N 271 
MET SD   S  N N 272 
MET CE   C  N N 273 
MET OXT  O  N N 274 
MET H    H  N N 275 
MET H2   H  N N 276 
MET HA   H  N N 277 
MET HB2  H  N N 278 
MET HB3  H  N N 279 
MET HG2  H  N N 280 
MET HG3  H  N N 281 
MET HE1  H  N N 282 
MET HE2  H  N N 283 
MET HE3  H  N N 284 
MET HXT  H  N N 285 
PEG C1   C  N N 286 
PEG O1   O  N N 287 
PEG C2   C  N N 288 
PEG O2   O  N N 289 
PEG C3   C  N N 290 
PEG C4   C  N N 291 
PEG O4   O  N N 292 
PEG H11  H  N N 293 
PEG H12  H  N N 294 
PEG HO1  H  N N 295 
PEG H21  H  N N 296 
PEG H22  H  N N 297 
PEG H31  H  N N 298 
PEG H32  H  N N 299 
PEG H41  H  N N 300 
PEG H42  H  N N 301 
PEG HO4  H  N N 302 
PHE N    N  N N 303 
PHE CA   C  N S 304 
PHE C    C  N N 305 
PHE O    O  N N 306 
PHE CB   C  N N 307 
PHE CG   C  Y N 308 
PHE CD1  C  Y N 309 
PHE CD2  C  Y N 310 
PHE CE1  C  Y N 311 
PHE CE2  C  Y N 312 
PHE CZ   C  Y N 313 
PHE OXT  O  N N 314 
PHE H    H  N N 315 
PHE H2   H  N N 316 
PHE HA   H  N N 317 
PHE HB2  H  N N 318 
PHE HB3  H  N N 319 
PHE HD1  H  N N 320 
PHE HD2  H  N N 321 
PHE HE1  H  N N 322 
PHE HE2  H  N N 323 
PHE HZ   H  N N 324 
PHE HXT  H  N N 325 
PO4 P    P  N N 326 
PO4 O1   O  N N 327 
PO4 O2   O  N N 328 
PO4 O3   O  N N 329 
PO4 O4   O  N N 330 
PRO N    N  N N 331 
PRO CA   C  N S 332 
PRO C    C  N N 333 
PRO O    O  N N 334 
PRO CB   C  N N 335 
PRO CG   C  N N 336 
PRO CD   C  N N 337 
PRO OXT  O  N N 338 
PRO H    H  N N 339 
PRO HA   H  N N 340 
PRO HB2  H  N N 341 
PRO HB3  H  N N 342 
PRO HG2  H  N N 343 
PRO HG3  H  N N 344 
PRO HD2  H  N N 345 
PRO HD3  H  N N 346 
PRO HXT  H  N N 347 
SER N    N  N N 348 
SER CA   C  N S 349 
SER C    C  N N 350 
SER O    O  N N 351 
SER CB   C  N N 352 
SER OG   O  N N 353 
SER OXT  O  N N 354 
SER H    H  N N 355 
SER H2   H  N N 356 
SER HA   H  N N 357 
SER HB2  H  N N 358 
SER HB3  H  N N 359 
SER HG   H  N N 360 
SER HXT  H  N N 361 
THR N    N  N N 362 
THR CA   C  N S 363 
THR C    C  N N 364 
THR O    O  N N 365 
THR CB   C  N R 366 
THR OG1  O  N N 367 
THR CG2  C  N N 368 
THR OXT  O  N N 369 
THR H    H  N N 370 
THR H2   H  N N 371 
THR HA   H  N N 372 
THR HB   H  N N 373 
THR HG1  H  N N 374 
THR HG21 H  N N 375 
THR HG22 H  N N 376 
THR HG23 H  N N 377 
THR HXT  H  N N 378 
TRP N    N  N N 379 
TRP CA   C  N S 380 
TRP C    C  N N 381 
TRP O    O  N N 382 
TRP CB   C  N N 383 
TRP CG   C  Y N 384 
TRP CD1  C  Y N 385 
TRP CD2  C  Y N 386 
TRP NE1  N  Y N 387 
TRP CE2  C  Y N 388 
TRP CE3  C  Y N 389 
TRP CZ2  C  Y N 390 
TRP CZ3  C  Y N 391 
TRP CH2  C  Y N 392 
TRP OXT  O  N N 393 
TRP H    H  N N 394 
TRP H2   H  N N 395 
TRP HA   H  N N 396 
TRP HB2  H  N N 397 
TRP HB3  H  N N 398 
TRP HD1  H  N N 399 
TRP HE1  H  N N 400 
TRP HE3  H  N N 401 
TRP HZ2  H  N N 402 
TRP HZ3  H  N N 403 
TRP HH2  H  N N 404 
TRP HXT  H  N N 405 
TYR N    N  N N 406 
TYR CA   C  N S 407 
TYR C    C  N N 408 
TYR O    O  N N 409 
TYR CB   C  N N 410 
TYR CG   C  Y N 411 
TYR CD1  C  Y N 412 
TYR CD2  C  Y N 413 
TYR CE1  C  Y N 414 
TYR CE2  C  Y N 415 
TYR CZ   C  Y N 416 
TYR OH   O  N N 417 
TYR OXT  O  N N 418 
TYR H    H  N N 419 
TYR H2   H  N N 420 
TYR HA   H  N N 421 
TYR HB2  H  N N 422 
TYR HB3  H  N N 423 
TYR HD1  H  N N 424 
TYR HD2  H  N N 425 
TYR HE1  H  N N 426 
TYR HE2  H  N N 427 
TYR HH   H  N N 428 
TYR HXT  H  N N 429 
UWS N1   N  N N 430 
UWS C4   C  N N 431 
UWS C5   C  N N 432 
UWS C6   C  N N 433 
UWS C7   C  N N 434 
UWS C8   C  N N 435 
UWS N    N  N N 436 
UWS C    C  N N 437 
UWS O    O  N N 438 
UWS C1   C  Y N 439 
UWS C2   C  Y N 440 
UWS C3   C  Y N 441 
UWS C9   C  N N 442 
UWS N2   N  Y N 443 
UWS O1   O  Y N 444 
UWS H1   H  N N 445 
UWS H2   H  N N 446 
UWS H3   H  N N 447 
UWS H4   H  N N 448 
UWS H5   H  N N 449 
UWS H6   H  N N 450 
UWS H7   H  N N 451 
UWS H8   H  N N 452 
UWS H9   H  N N 453 
UWS H10  H  N N 454 
UWS H11  H  N N 455 
VAL N    N  N N 456 
VAL CA   C  N S 457 
VAL C    C  N N 458 
VAL O    O  N N 459 
VAL CB   C  N N 460 
VAL CG1  C  N N 461 
VAL CG2  C  N N 462 
VAL OXT  O  N N 463 
VAL H    H  N N 464 
VAL H2   H  N N 465 
VAL HA   H  N N 466 
VAL HB   H  N N 467 
VAL HG11 H  N N 468 
VAL HG12 H  N N 469 
VAL HG13 H  N N 470 
VAL HG21 H  N N 471 
VAL HG22 H  N N 472 
VAL HG23 H  N N 473 
VAL HXT  H  N N 474 
ZN  ZN   ZN N N 475 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
DMS S   O    doub N N 83  
DMS S   C1   sing N N 84  
DMS S   C2   sing N N 85  
DMS C1  H11  sing N N 86  
DMS C1  H12  sing N N 87  
DMS C1  H13  sing N N 88  
DMS C2  H21  sing N N 89  
DMS C2  H22  sing N N 90  
DMS C2  H23  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
HIS N   CA   sing N N 138 
HIS N   H    sing N N 139 
HIS N   H2   sing N N 140 
HIS CA  C    sing N N 141 
HIS CA  CB   sing N N 142 
HIS CA  HA   sing N N 143 
HIS C   O    doub N N 144 
HIS C   OXT  sing N N 145 
HIS CB  CG   sing N N 146 
HIS CB  HB2  sing N N 147 
HIS CB  HB3  sing N N 148 
HIS CG  ND1  sing Y N 149 
HIS CG  CD2  doub Y N 150 
HIS ND1 CE1  doub Y N 151 
HIS ND1 HD1  sing N N 152 
HIS CD2 NE2  sing Y N 153 
HIS CD2 HD2  sing N N 154 
HIS CE1 NE2  sing Y N 155 
HIS CE1 HE1  sing N N 156 
HIS NE2 HE2  sing N N 157 
HIS OXT HXT  sing N N 158 
HOH O   H1   sing N N 159 
HOH O   H2   sing N N 160 
ILE N   CA   sing N N 161 
ILE N   H    sing N N 162 
ILE N   H2   sing N N 163 
ILE CA  C    sing N N 164 
ILE CA  CB   sing N N 165 
ILE CA  HA   sing N N 166 
ILE C   O    doub N N 167 
ILE C   OXT  sing N N 168 
ILE CB  CG1  sing N N 169 
ILE CB  CG2  sing N N 170 
ILE CB  HB   sing N N 171 
ILE CG1 CD1  sing N N 172 
ILE CG1 HG12 sing N N 173 
ILE CG1 HG13 sing N N 174 
ILE CG2 HG21 sing N N 175 
ILE CG2 HG22 sing N N 176 
ILE CG2 HG23 sing N N 177 
ILE CD1 HD11 sing N N 178 
ILE CD1 HD12 sing N N 179 
ILE CD1 HD13 sing N N 180 
ILE OXT HXT  sing N N 181 
LEU N   CA   sing N N 182 
LEU N   H    sing N N 183 
LEU N   H2   sing N N 184 
LEU CA  C    sing N N 185 
LEU CA  CB   sing N N 186 
LEU CA  HA   sing N N 187 
LEU C   O    doub N N 188 
LEU C   OXT  sing N N 189 
LEU CB  CG   sing N N 190 
LEU CB  HB2  sing N N 191 
LEU CB  HB3  sing N N 192 
LEU CG  CD1  sing N N 193 
LEU CG  CD2  sing N N 194 
LEU CG  HG   sing N N 195 
LEU CD1 HD11 sing N N 196 
LEU CD1 HD12 sing N N 197 
LEU CD1 HD13 sing N N 198 
LEU CD2 HD21 sing N N 199 
LEU CD2 HD22 sing N N 200 
LEU CD2 HD23 sing N N 201 
LEU OXT HXT  sing N N 202 
LYS N   CA   sing N N 203 
LYS N   H    sing N N 204 
LYS N   H2   sing N N 205 
LYS CA  C    sing N N 206 
LYS CA  CB   sing N N 207 
LYS CA  HA   sing N N 208 
LYS C   O    doub N N 209 
LYS C   OXT  sing N N 210 
LYS CB  CG   sing N N 211 
LYS CB  HB2  sing N N 212 
LYS CB  HB3  sing N N 213 
LYS CG  CD   sing N N 214 
LYS CG  HG2  sing N N 215 
LYS CG  HG3  sing N N 216 
LYS CD  CE   sing N N 217 
LYS CD  HD2  sing N N 218 
LYS CD  HD3  sing N N 219 
LYS CE  NZ   sing N N 220 
LYS CE  HE2  sing N N 221 
LYS CE  HE3  sing N N 222 
LYS NZ  HZ1  sing N N 223 
LYS NZ  HZ2  sing N N 224 
LYS NZ  HZ3  sing N N 225 
LYS OXT HXT  sing N N 226 
MES O1  C2   sing N N 227 
MES O1  C6   sing N N 228 
MES C2  C3   sing N N 229 
MES C2  H21  sing N N 230 
MES C2  H22  sing N N 231 
MES C3  N4   sing N N 232 
MES C3  H31  sing N N 233 
MES C3  H32  sing N N 234 
MES N4  C5   sing N N 235 
MES N4  C7   sing N N 236 
MES N4  HN4  sing N N 237 
MES C5  C6   sing N N 238 
MES C5  H51  sing N N 239 
MES C5  H52  sing N N 240 
MES C6  H61  sing N N 241 
MES C6  H62  sing N N 242 
MES C7  C8   sing N N 243 
MES C7  H71  sing N N 244 
MES C7  H72  sing N N 245 
MES C8  S    sing N N 246 
MES C8  H81  sing N N 247 
MES C8  H82  sing N N 248 
MES S   O1S  doub N N 249 
MES S   O2S  doub N N 250 
MES S   O3S  sing N N 251 
MET N   CA   sing N N 252 
MET N   H    sing N N 253 
MET N   H2   sing N N 254 
MET CA  C    sing N N 255 
MET CA  CB   sing N N 256 
MET CA  HA   sing N N 257 
MET C   O    doub N N 258 
MET C   OXT  sing N N 259 
MET CB  CG   sing N N 260 
MET CB  HB2  sing N N 261 
MET CB  HB3  sing N N 262 
MET CG  SD   sing N N 263 
MET CG  HG2  sing N N 264 
MET CG  HG3  sing N N 265 
MET SD  CE   sing N N 266 
MET CE  HE1  sing N N 267 
MET CE  HE2  sing N N 268 
MET CE  HE3  sing N N 269 
MET OXT HXT  sing N N 270 
PEG C1  O1   sing N N 271 
PEG C1  C2   sing N N 272 
PEG C1  H11  sing N N 273 
PEG C1  H12  sing N N 274 
PEG O1  HO1  sing N N 275 
PEG C2  O2   sing N N 276 
PEG C2  H21  sing N N 277 
PEG C2  H22  sing N N 278 
PEG O2  C3   sing N N 279 
PEG C3  C4   sing N N 280 
PEG C3  H31  sing N N 281 
PEG C3  H32  sing N N 282 
PEG C4  O4   sing N N 283 
PEG C4  H41  sing N N 284 
PEG C4  H42  sing N N 285 
PEG O4  HO4  sing N N 286 
PHE N   CA   sing N N 287 
PHE N   H    sing N N 288 
PHE N   H2   sing N N 289 
PHE CA  C    sing N N 290 
PHE CA  CB   sing N N 291 
PHE CA  HA   sing N N 292 
PHE C   O    doub N N 293 
PHE C   OXT  sing N N 294 
PHE CB  CG   sing N N 295 
PHE CB  HB2  sing N N 296 
PHE CB  HB3  sing N N 297 
PHE CG  CD1  doub Y N 298 
PHE CG  CD2  sing Y N 299 
PHE CD1 CE1  sing Y N 300 
PHE CD1 HD1  sing N N 301 
PHE CD2 CE2  doub Y N 302 
PHE CD2 HD2  sing N N 303 
PHE CE1 CZ   doub Y N 304 
PHE CE1 HE1  sing N N 305 
PHE CE2 CZ   sing Y N 306 
PHE CE2 HE2  sing N N 307 
PHE CZ  HZ   sing N N 308 
PHE OXT HXT  sing N N 309 
PO4 P   O1   doub N N 310 
PO4 P   O2   sing N N 311 
PO4 P   O3   sing N N 312 
PO4 P   O4   sing N N 313 
PRO N   CA   sing N N 314 
PRO N   CD   sing N N 315 
PRO N   H    sing N N 316 
PRO CA  C    sing N N 317 
PRO CA  CB   sing N N 318 
PRO CA  HA   sing N N 319 
PRO C   O    doub N N 320 
PRO C   OXT  sing N N 321 
PRO CB  CG   sing N N 322 
PRO CB  HB2  sing N N 323 
PRO CB  HB3  sing N N 324 
PRO CG  CD   sing N N 325 
PRO CG  HG2  sing N N 326 
PRO CG  HG3  sing N N 327 
PRO CD  HD2  sing N N 328 
PRO CD  HD3  sing N N 329 
PRO OXT HXT  sing N N 330 
SER N   CA   sing N N 331 
SER N   H    sing N N 332 
SER N   H2   sing N N 333 
SER CA  C    sing N N 334 
SER CA  CB   sing N N 335 
SER CA  HA   sing N N 336 
SER C   O    doub N N 337 
SER C   OXT  sing N N 338 
SER CB  OG   sing N N 339 
SER CB  HB2  sing N N 340 
SER CB  HB3  sing N N 341 
SER OG  HG   sing N N 342 
SER OXT HXT  sing N N 343 
THR N   CA   sing N N 344 
THR N   H    sing N N 345 
THR N   H2   sing N N 346 
THR CA  C    sing N N 347 
THR CA  CB   sing N N 348 
THR CA  HA   sing N N 349 
THR C   O    doub N N 350 
THR C   OXT  sing N N 351 
THR CB  OG1  sing N N 352 
THR CB  CG2  sing N N 353 
THR CB  HB   sing N N 354 
THR OG1 HG1  sing N N 355 
THR CG2 HG21 sing N N 356 
THR CG2 HG22 sing N N 357 
THR CG2 HG23 sing N N 358 
THR OXT HXT  sing N N 359 
TRP N   CA   sing N N 360 
TRP N   H    sing N N 361 
TRP N   H2   sing N N 362 
TRP CA  C    sing N N 363 
TRP CA  CB   sing N N 364 
TRP CA  HA   sing N N 365 
TRP C   O    doub N N 366 
TRP C   OXT  sing N N 367 
TRP CB  CG   sing N N 368 
TRP CB  HB2  sing N N 369 
TRP CB  HB3  sing N N 370 
TRP CG  CD1  doub Y N 371 
TRP CG  CD2  sing Y N 372 
TRP CD1 NE1  sing Y N 373 
TRP CD1 HD1  sing N N 374 
TRP CD2 CE2  doub Y N 375 
TRP CD2 CE3  sing Y N 376 
TRP NE1 CE2  sing Y N 377 
TRP NE1 HE1  sing N N 378 
TRP CE2 CZ2  sing Y N 379 
TRP CE3 CZ3  doub Y N 380 
TRP CE3 HE3  sing N N 381 
TRP CZ2 CH2  doub Y N 382 
TRP CZ2 HZ2  sing N N 383 
TRP CZ3 CH2  sing Y N 384 
TRP CZ3 HZ3  sing N N 385 
TRP CH2 HH2  sing N N 386 
TRP OXT HXT  sing N N 387 
TYR N   CA   sing N N 388 
TYR N   H    sing N N 389 
TYR N   H2   sing N N 390 
TYR CA  C    sing N N 391 
TYR CA  CB   sing N N 392 
TYR CA  HA   sing N N 393 
TYR C   O    doub N N 394 
TYR C   OXT  sing N N 395 
TYR CB  CG   sing N N 396 
TYR CB  HB2  sing N N 397 
TYR CB  HB3  sing N N 398 
TYR CG  CD1  doub Y N 399 
TYR CG  CD2  sing Y N 400 
TYR CD1 CE1  sing Y N 401 
TYR CD1 HD1  sing N N 402 
TYR CD2 CE2  doub Y N 403 
TYR CD2 HD2  sing N N 404 
TYR CE1 CZ   doub Y N 405 
TYR CE1 HE1  sing N N 406 
TYR CE2 CZ   sing Y N 407 
TYR CE2 HE2  sing N N 408 
TYR CZ  OH   sing N N 409 
TYR OH  HH   sing N N 410 
TYR OXT HXT  sing N N 411 
UWS C   C1   sing N N 412 
UWS C1  N2   doub Y N 413 
UWS C1  C2   sing Y N 414 
UWS N2  O1   sing Y N 415 
UWS C2  C3   doub Y N 416 
UWS O1  C3   sing Y N 417 
UWS C3  C4   sing N N 418 
UWS C4  N    sing N N 419 
UWS N1  N    sing N N 420 
UWS N1  C5   doub N N 421 
UWS N   C9   sing N N 422 
UWS O   C9   doub N N 423 
UWS C6  C5   sing N N 424 
UWS C9  C8   sing N N 425 
UWS C5  C7   sing N N 426 
UWS C8  C7   doub N N 427 
UWS C4  H1   sing N N 428 
UWS C4  H2   sing N N 429 
UWS C6  H3   sing N N 430 
UWS C6  H4   sing N N 431 
UWS C6  H5   sing N N 432 
UWS C7  H6   sing N N 433 
UWS C8  H7   sing N N 434 
UWS C   H8   sing N N 435 
UWS C   H9   sing N N 436 
UWS C   H10  sing N N 437 
UWS C2  H11  sing N N 438 
VAL N   CA   sing N N 439 
VAL N   H    sing N N 440 
VAL N   H2   sing N N 441 
VAL CA  C    sing N N 442 
VAL CA  CB   sing N N 443 
VAL CA  HA   sing N N 444 
VAL C   O    doub N N 445 
VAL C   OXT  sing N N 446 
VAL CB  CG1  sing N N 447 
VAL CB  CG2  sing N N 448 
VAL CB  HB   sing N N 449 
VAL CG1 HG11 sing N N 450 
VAL CG1 HG12 sing N N 451 
VAL CG1 HG13 sing N N 452 
VAL CG2 HG21 sing N N 453 
VAL CG2 HG22 sing N N 454 
VAL CG2 HG23 sing N N 455 
VAL OXT HXT  sing N N 456 
# 
_pdbx_audit_support.ordinal                1 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)' 
_pdbx_audit_support.grant_number           U19AI171292 
_pdbx_audit_support.country                'United States' 
# 
_pdbx_deposit_group.group_id            G_1002341 
_pdbx_deposit_group.group_description   
'Crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_title         
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_type          'changed state' 
# 
_atom_sites.entry_id                    7I2G 
_atom_sites.fract_transf_matrix[1][1]   0.012133 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.008618 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006785 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
# 
loop_
_atom_type.symbol 
C  
CL 
N  
O  
P  
S  
ZN 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ASN A 1 10  ? -12.943 -6.454  -11.983 1.00 104.98 ? 273  ASN A N   1 
ATOM   2    C  CA  . ASN A 1 10  ? -12.837 -6.877  -10.550 1.00 108.13 ? 273  ASN A CA  1 
ATOM   3    C  C   . ASN A 1 10  ? -14.201 -6.621  -9.872  1.00 111.05 ? 273  ASN A C   1 
ATOM   4    O  O   . ASN A 1 10  ? -15.232 -6.962  -10.501 1.00 101.47 ? 273  ASN A O   1 
ATOM   5    C  CB  . ASN A 1 10  ? -11.607 -6.225  -9.897  1.00 108.85 ? 273  ASN A CB  1 
ATOM   6    C  CG  . ASN A 1 10  ? -11.020 -6.997  -8.729  1.00 105.94 ? 273  ASN A CG  1 
ATOM   7    O  OD1 . ASN A 1 10  ? -11.721 -7.724  -8.031  1.00 104.45 ? 273  ASN A OD1 1 
ATOM   8    N  ND2 . ASN A 1 10  ? -9.727  -6.840  -8.495  1.00 100.25 ? 273  ASN A ND2 1 
ATOM   9    N  N   . LEU A 1 11  ? -14.217 -6.015  -8.671  1.00 110.52 ? 274  LEU A N   1 
ATOM   10   C  CA  . LEU A 1 11  ? -15.329 -6.079  -7.672  1.00 96.73  ? 274  LEU A CA  1 
ATOM   11   C  C   . LEU A 1 11  ? -16.635 -5.514  -8.235  1.00 85.14  ? 274  LEU A C   1 
ATOM   12   O  O   . LEU A 1 11  ? -17.702 -5.880  -7.713  1.00 77.69  ? 274  LEU A O   1 
ATOM   13   C  CB  . LEU A 1 11  ? -14.915 -5.332  -6.399  1.00 104.96 ? 274  LEU A CB  1 
ATOM   14   C  CG  . LEU A 1 11  ? -14.030 -6.132  -5.440  1.00 114.73 ? 274  LEU A CG  1 
ATOM   15   C  CD1 . LEU A 1 11  ? -13.012 -5.239  -4.740  1.00 114.86 ? 274  LEU A CD1 1 
ATOM   16   C  CD2 . LEU A 1 11  ? -14.879 -6.888  -4.425  1.00 117.40 ? 274  LEU A CD2 1 
ATOM   17   N  N   . ASP A 1 12  ? -16.564 -4.660  -9.255  1.00 76.35  ? 275  ASP A N   1 
ATOM   18   C  CA  . ASP A 1 12  ? -17.766 -4.032  -9.859  1.00 83.66  ? 275  ASP A CA  1 
ATOM   19   C  C   . ASP A 1 12  ? -18.646 -5.094  -10.541 1.00 83.27  ? 275  ASP A C   1 
ATOM   20   O  O   . ASP A 1 12  ? -19.835 -4.791  -10.714 1.00 83.92  ? 275  ASP A O   1 
ATOM   21   C  CB  . ASP A 1 12  ? -17.374 -2.906  -10.820 1.00 90.81  ? 275  ASP A CB  1 
ATOM   22   C  CG  . ASP A 1 12  ? -16.685 -3.406  -12.073 1.00 94.60  ? 275  ASP A CG  1 
ATOM   23   O  OD1 . ASP A 1 12  ? -15.745 -4.220  -11.934 1.00 99.87  ? 275  ASP A OD1 1 
ATOM   24   O  OD2 . ASP A 1 12  ? -17.117 -3.005  -13.174 1.00 99.45  ? 275  ASP A OD2 1 
ATOM   25   N  N   . ILE A 1 13  ? -18.099 -6.268  -10.918 1.00 78.93  ? 276  ILE A N   1 
ATOM   26   C  CA  . ILE A 1 13  ? -18.817 -7.376  -11.637 1.00 67.73  ? 276  ILE A CA  1 
ATOM   27   C  C   . ILE A 1 13  ? -19.227 -8.493  -10.657 1.00 66.68  ? 276  ILE A C   1 
ATOM   28   O  O   . ILE A 1 13  ? -20.306 -9.108  -10.858 1.00 57.78  ? 276  ILE A O   1 
ATOM   29   C  CB  . ILE A 1 13  ? -17.955 -7.897  -12.808 1.00 68.04  ? 276  ILE A CB  1 
ATOM   30   C  CG1 . ILE A 1 13  ? -17.885 -6.853  -13.928 1.00 62.85  ? 276  ILE A CG1 1 
ATOM   31   C  CG2 . ILE A 1 13  ? -18.446 -9.252  -13.316 1.00 63.85  ? 276  ILE A CG2 1 
ATOM   32   C  CD1 . ILE A 1 13  ? -17.046 -7.260  -15.117 1.00 62.02  ? 276  ILE A CD1 1 
ATOM   33   N  N   . ILE A 1 14  ? -18.436 -8.721  -9.609  1.00 66.19  ? 277  ILE A N   1 
ATOM   34   C  CA  . ILE A 1 14  ? -18.644 -9.834  -8.638  1.00 75.44  ? 277  ILE A CA  1 
ATOM   35   C  C   . ILE A 1 14  ? -19.270 -9.304  -7.344  1.00 76.53  ? 277  ILE A C   1 
ATOM   36   O  O   . ILE A 1 14  ? -19.902 -10.116 -6.629  1.00 72.36  ? 277  ILE A O   1 
ATOM   37   C  CB  . ILE A 1 14  ? -17.308 -10.558 -8.381  1.00 83.80  ? 277  ILE A CB  1 
ATOM   38   C  CG1 . ILE A 1 14  ? -16.183 -9.572  -8.047  1.00 81.47  ? 277  ILE A CG1 1 
ATOM   39   C  CG2 . ILE A 1 14  ? -16.950 -11.437 -9.570  1.00 84.21  ? 277  ILE A CG2 1 
ATOM   40   C  CD1 . ILE A 1 14  ? -14.932 -10.223 -7.509  1.00 85.97  ? 277  ILE A CD1 1 
ATOM   41   N  N   . GLY A 1 15  ? -19.094 -8.007  -7.051  1.00 85.03  ? 278  GLY A N   1 
ATOM   42   C  CA  . GLY A 1 15  ? -19.600 -7.331  -5.834  1.00 82.54  ? 278  GLY A CA  1 
ATOM   43   C  C   . GLY A 1 15  ? -21.016 -7.757  -5.469  1.00 79.88  ? 278  GLY A C   1 
ATOM   44   O  O   . GLY A 1 15  ? -21.197 -8.352  -4.392  1.00 84.97  ? 278  GLY A O   1 
ATOM   45   N  N   . LYS A 1 16  ? -21.987 -7.488  -6.344  1.00 74.61  ? 279  LYS A N   1 
ATOM   46   C  CA  . LYS A 1 16  ? -23.431 -7.752  -6.101  1.00 71.12  ? 279  LYS A CA  1 
ATOM   47   C  C   . LYS A 1 16  ? -23.589 -9.161  -5.517  1.00 70.61  ? 279  LYS A C   1 
ATOM   48   O  O   . LYS A 1 16  ? -24.248 -9.291  -4.471  1.00 64.45  ? 279  LYS A O   1 
ATOM   49   C  CB  . LYS A 1 16  ? -24.199 -7.552  -7.412  1.00 76.88  ? 279  LYS A CB  1 
ATOM   50   C  CG  . LYS A 1 16  ? -25.721 -7.561  -7.317  1.00 83.39  ? 279  LYS A CG  1 
ATOM   51   C  CD  . LYS A 1 16  ? -26.386 -6.685  -8.378  1.00 85.82  ? 279  LYS A CD  1 
ATOM   52   C  CE  . LYS A 1 16  ? -27.746 -7.189  -8.816  1.00 89.32  ? 279  LYS A CE  1 
ATOM   53   N  NZ  . LYS A 1 16  ? -28.743 -7.137  -7.721  1.00 91.60  ? 279  LYS A NZ  1 
ATOM   54   N  N   . ARG A 1 17  ? -22.992 -10.165 -6.172  1.00 72.42  ? 280  ARG A N   1 
ATOM   55   C  CA  . ARG A 1 17  ? -23.034 -11.591 -5.748  1.00 74.98  ? 280  ARG A CA  1 
ATOM   56   C  C   . ARG A 1 17  ? -22.431 -11.709 -4.353  1.00 73.45  ? 280  ARG A C   1 
ATOM   57   O  O   . ARG A 1 17  ? -23.006 -12.426 -3.526  1.00 78.86  ? 280  ARG A O   1 
ATOM   58   C  CB  . ARG A 1 17  ? -22.237 -12.496 -6.695  1.00 79.36  ? 280  ARG A CB  1 
ATOM   59   C  CG  . ARG A 1 17  ? -23.071 -13.187 -7.763  1.00 77.89  ? 280  ARG A CG  1 
ATOM   60   C  CD  . ARG A 1 17  ? -22.208 -13.917 -8.773  1.00 64.51  ? 280  ARG A CD  1 
ATOM   61   N  NE  . ARG A 1 17  ? -21.563 -12.986 -9.679  1.00 62.72  ? 280  ARG A NE  1 
ATOM   62   C  CZ  . ARG A 1 17  ? -20.727 -13.328 -10.653 1.00 62.71  ? 280  ARG A CZ  1 
ATOM   63   N  NH1 . ARG A 1 17  ? -20.406 -14.598 -10.841 1.00 63.44  ? 280  ARG A NH1 1 
ATOM   64   N  NH2 . ARG A 1 17  ? -20.213 -12.395 -11.438 1.00 56.88  ? 280  ARG A NH2 1 
ATOM   65   N  N   . ILE A 1 18  ? -21.301 -11.034 -4.134  1.00 84.94  ? 281  ILE A N   1 
ATOM   66   C  CA  . ILE A 1 18  ? -20.572 -10.996 -2.832  1.00 89.35  ? 281  ILE A CA  1 
ATOM   67   C  C   . ILE A 1 18  ? -21.483 -10.337 -1.780  1.00 94.19  ? 281  ILE A C   1 
ATOM   68   O  O   . ILE A 1 18  ? -21.711 -10.954 -0.707  1.00 91.38  ? 281  ILE A O   1 
ATOM   69   C  CB  . ILE A 1 18  ? -19.198 -10.307 -3.007  1.00 88.96  ? 281  ILE A CB  1 
ATOM   70   C  CG1 . ILE A 1 18  ? -18.270 -11.163 -3.871  1.00 87.68  ? 281  ILE A CG1 1 
ATOM   71   C  CG2 . ILE A 1 18  ? -18.550 -9.981  -1.669  1.00 90.18  ? 281  ILE A CG2 1 
ATOM   72   C  CD1 . ILE A 1 18  ? -16.999 -10.471 -4.283  1.00 88.00  ? 281  ILE A CD1 1 
ATOM   73   N  N   . GLU A 1 19  ? -21.999 -9.140  -2.092  0.34 93.34  ? 282  GLU A N   1 
ATOM   74   C  CA  . GLU A 1 19  ? -22.872 -8.317  -1.208  0.34 92.56  ? 282  GLU A CA  1 
ATOM   75   C  C   . GLU A 1 19  ? -24.086 -9.139  -0.760  0.34 89.44  ? 282  GLU A C   1 
ATOM   76   O  O   . GLU A 1 19  ? -24.395 -9.121  0.447   0.34 90.07  ? 282  GLU A O   1 
ATOM   77   C  CB  . GLU A 1 19  ? -23.343 -7.055  -1.933  0.34 94.94  ? 282  GLU A CB  1 
ATOM   78   C  CG  . GLU A 1 19  ? -22.252 -6.019  -2.136  0.34 98.09  ? 282  GLU A CG  1 
ATOM   79   C  CD  . GLU A 1 19  ? -22.658 -4.848  -3.015  0.34 100.57 ? 282  GLU A CD  1 
ATOM   80   O  OE1 . GLU A 1 19  ? -23.839 -4.796  -3.421  0.34 102.54 ? 282  GLU A OE1 1 
ATOM   81   O  OE2 . GLU A 1 19  ? -21.794 -3.992  -3.296  0.34 102.37 ? 282  GLU A OE2 1 
ATOM   82   N  N   . LYS A 1 20  ? -24.746 -9.823  -1.700  0.34 86.02  ? 283  LYS A N   1 
ATOM   83   C  CA  . LYS A 1 20  ? -25.970 -10.628 -1.442  0.34 83.36  ? 283  LYS A CA  1 
ATOM   84   C  C   . LYS A 1 20  ? -25.662 -11.729 -0.423  0.34 82.55  ? 283  LYS A C   1 
ATOM   85   O  O   . LYS A 1 20  ? -26.490 -11.929 0.488   0.34 82.24  ? 283  LYS A O   1 
ATOM   86   C  CB  . LYS A 1 20  ? -26.505 -11.248 -2.735  0.34 83.00  ? 283  LYS A CB  1 
ATOM   87   C  CG  . LYS A 1 20  ? -27.651 -12.231 -2.536  0.34 82.90  ? 283  LYS A CG  1 
ATOM   88   C  CD  . LYS A 1 20  ? -28.513 -12.411 -3.766  0.34 83.92  ? 283  LYS A CD  1 
ATOM   89   C  CE  . LYS A 1 20  ? -29.793 -13.173 -3.492  0.34 83.25  ? 283  LYS A CE  1 
ATOM   90   N  NZ  . LYS A 1 20  ? -29.521 -14.564 -3.063  0.34 83.42  ? 283  LYS A NZ  1 
ATOM   91   N  N   . ILE A 1 21  ? -24.528 -12.421 -0.586  1.00 81.48  ? 284  ILE A N   1 
ATOM   92   C  CA  . ILE A 1 21  ? -24.124 -13.549 0.309   1.00 86.38  ? 284  ILE A CA  1 
ATOM   93   C  C   . ILE A 1 21  ? -23.767 -12.971 1.686   1.00 85.39  ? 284  ILE A C   1 
ATOM   94   O  O   . ILE A 1 21  ? -24.238 -13.535 2.704   1.00 73.81  ? 284  ILE A O   1 
ATOM   95   C  CB  . ILE A 1 21  ? -22.958 -14.372 -0.285  1.00 93.87  ? 284  ILE A CB  1 
ATOM   96   C  CG1 . ILE A 1 21  ? -23.294 -14.957 -1.660  1.00 89.84  ? 284  ILE A CG1 1 
ATOM   97   C  CG2 . ILE A 1 21  ? -22.521 -15.470 0.682   1.00 92.46  ? 284  ILE A CG2 1 
ATOM   98   C  CD1 . ILE A 1 21  ? -22.075 -15.321 -2.487  1.00 85.12  ? 284  ILE A CD1 1 
ATOM   99   N  N   . LYS A 1 22  ? -22.982 -11.886 1.708   1.00 82.73  ? 285  LYS A N   1 
ATOM   100  C  CA  . LYS A 1 22  ? -22.523 -11.196 2.947   1.00 92.25  ? 285  LYS A CA  1 
ATOM   101  C  C   . LYS A 1 22  ? -23.727 -10.863 3.835   1.00 90.88  ? 285  LYS A C   1 
ATOM   102  O  O   . LYS A 1 22  ? -23.579 -10.943 5.059   1.00 96.12  ? 285  LYS A O   1 
ATOM   103  C  CB  . LYS A 1 22  ? -21.733 -9.930  2.602   1.00 100.33 ? 285  LYS A CB  1 
ATOM   104  C  CG  . LYS A 1 22  ? -21.269 -9.104  3.796   1.00 111.60 ? 285  LYS A CG  1 
ATOM   105  C  CD  . LYS A 1 22  ? -20.184 -8.094  3.457   1.00 119.83 ? 285  LYS A CD  1 
ATOM   106  C  CE  . LYS A 1 22  ? -19.902 -7.124  4.587   1.00 126.73 ? 285  LYS A CE  1 
ATOM   107  N  NZ  . LYS A 1 22  ? -18.636 -6.381  4.377   1.00 125.55 ? 285  LYS A NZ  1 
ATOM   108  N  N   . GLN A 1 23  ? -24.869 -10.522 3.232   1.00 97.99  ? 286  GLN A N   1 
ATOM   109  C  CA  . GLN A 1 23  ? -26.108 -10.088 3.934   1.00 99.65  ? 286  GLN A CA  1 
ATOM   110  C  C   . GLN A 1 23  ? -26.932 -11.281 4.446   1.00 102.78 ? 286  GLN A C   1 
ATOM   111  O  O   . GLN A 1 23  ? -27.591 -11.143 5.479   1.00 116.41 ? 286  GLN A O   1 
ATOM   112  C  CB  . GLN A 1 23  ? -26.932 -9.173  3.025   1.00 98.26  ? 286  GLN A CB  1 
ATOM   113  C  CG  . GLN A 1 23  ? -26.329 -7.780  2.897   1.00 102.86 ? 286  GLN A CG  1 
ATOM   114  C  CD  . GLN A 1 23  ? -26.837 -7.010  1.702   1.00 105.78 ? 286  GLN A CD  1 
ATOM   115  O  OE1 . GLN A 1 23  ? -27.871 -7.331  1.120   1.00 108.64 ? 286  GLN A OE1 1 
ATOM   116  N  NE2 . GLN A 1 23  ? -26.105 -5.975  1.324   1.00 108.06 ? 286  GLN A NE2 1 
ATOM   117  N  N   . GLU A 1 24  ? -26.887 -12.413 3.734   0.34 105.40 ? 287  GLU A N   1 
ATOM   118  C  CA  . GLU A 1 24  ? -27.621 -13.661 4.080   0.34 107.75 ? 287  GLU A CA  1 
ATOM   119  C  C   . GLU A 1 24  ? -26.972 -14.315 5.305   0.34 109.34 ? 287  GLU A C   1 
ATOM   120  O  O   . GLU A 1 24  ? -27.634 -15.153 5.948   0.34 109.08 ? 287  GLU A O   1 
ATOM   121  C  CB  . GLU A 1 24  ? -27.627 -14.619 2.887   0.34 110.70 ? 287  GLU A CB  1 
ATOM   122  C  CG  . GLU A 1 24  ? -28.389 -14.084 1.688   0.34 113.62 ? 287  GLU A CG  1 
ATOM   123  C  CD  . GLU A 1 24  ? -28.003 -14.711 0.359   0.34 115.29 ? 287  GLU A CD  1 
ATOM   124  O  OE1 . GLU A 1 24  ? -28.487 -14.223 -0.682  0.34 116.56 ? 287  GLU A OE1 1 
ATOM   125  O  OE2 . GLU A 1 24  ? -27.217 -15.681 0.367   0.34 115.12 ? 287  GLU A OE2 1 
ATOM   126  N  N   . HIS A 1 25  ? -25.721 -13.949 5.604   0.34 112.29 ? 288  HIS A N   1 
ATOM   127  C  CA  . HIS A 1 25  ? -24.944 -14.428 6.778   0.34 113.52 ? 288  HIS A CA  1 
ATOM   128  C  C   . HIS A 1 25  ? -24.276 -13.232 7.468   0.34 115.54 ? 288  HIS A C   1 
ATOM   129  O  O   . HIS A 1 25  ? -23.070 -13.323 7.776   0.34 117.08 ? 288  HIS A O   1 
ATOM   130  C  CB  . HIS A 1 25  ? -23.934 -15.499 6.340   0.34 112.16 ? 288  HIS A CB  1 
ATOM   131  C  CG  . HIS A 1 25  ? -24.538 -16.613 5.550   0.34 109.79 ? 288  HIS A CG  1 
ATOM   132  N  ND1 . HIS A 1 25  ? -25.120 -17.715 6.150   0.34 110.08 ? 288  HIS A ND1 1 
ATOM   133  C  CD2 . HIS A 1 25  ? -24.652 -16.805 4.218   0.34 107.63 ? 288  HIS A CD2 1 
ATOM   134  C  CE1 . HIS A 1 25  ? -25.567 -18.536 5.220   0.34 108.06 ? 288  HIS A CE1 1 
ATOM   135  N  NE2 . HIS A 1 25  ? -25.292 -18.000 4.026   0.34 106.70 ? 288  HIS A NE2 1 
ATOM   136  N  N   . GLU A 1 26  ? -25.040 -12.158 7.700   0.34 117.35 ? 289  GLU A N   1 
ATOM   137  C  CA  . GLU A 1 26  ? -24.566 -10.883 8.307   0.34 118.29 ? 289  GLU A CA  1 
ATOM   138  C  C   . GLU A 1 26  ? -24.205 -11.121 9.778   0.34 118.77 ? 289  GLU A C   1 
ATOM   139  O  O   . GLU A 1 26  ? -23.255 -10.475 10.265  0.34 116.28 ? 289  GLU A O   1 
ATOM   140  C  CB  . GLU A 1 26  ? -25.639 -9.798  8.178   0.34 117.13 ? 289  GLU A CB  1 
ATOM   141  C  CG  . GLU A 1 26  ? -25.155 -8.408  8.558   0.34 115.75 ? 289  GLU A CG  1 
ATOM   142  C  CD  . GLU A 1 26  ? -24.419 -7.656  7.460   0.34 114.55 ? 289  GLU A CD  1 
ATOM   143  O  OE1 . GLU A 1 26  ? -23.375 -7.047  7.763   0.34 113.38 ? 289  GLU A OE1 1 
ATOM   144  O  OE2 . GLU A 1 26  ? -24.899 -7.668  6.308   0.34 111.37 ? 289  GLU A OE2 1 
ATOM   145  N  N   . THR A 1 27  ? -24.940 -12.012 10.453  0.34 118.91 ? 290  THR A N   1 
ATOM   146  C  CA  . THR A 1 27  ? -24.717 -12.399 11.873  0.34 119.15 ? 290  THR A CA  1 
ATOM   147  C  C   . THR A 1 27  ? -23.276 -12.899 12.036  0.34 118.23 ? 290  THR A C   1 
ATOM   148  O  O   . THR A 1 27  ? -22.567 -12.362 12.910  0.34 118.92 ? 290  THR A O   1 
ATOM   149  C  CB  . THR A 1 27  ? -25.752 -13.435 12.335  0.34 120.59 ? 290  THR A CB  1 
ATOM   150  O  OG1 . THR A 1 27  ? -25.829 -14.466 11.351  0.34 121.91 ? 290  THR A OG1 1 
ATOM   151  C  CG2 . THR A 1 27  ? -27.126 -12.839 12.552  0.34 119.69 ? 290  THR A CG2 1 
ATOM   152  N  N   . SER A 1 28  ? -22.862 -13.876 11.219  0.34 114.67 ? 291  SER A N   1 
ATOM   153  C  CA  . SER A 1 28  ? -21.500 -14.476 11.220  0.34 110.47 ? 291  SER A CA  1 
ATOM   154  C  C   . SER A 1 28  ? -20.750 -14.083 9.942   0.34 108.86 ? 291  SER A C   1 
ATOM   155  O  O   . SER A 1 28  ? -20.910 -14.789 8.927   0.34 109.20 ? 291  SER A O   1 
ATOM   156  C  CB  . SER A 1 28  ? -21.562 -15.975 11.363  0.34 108.33 ? 291  SER A CB  1 
ATOM   157  O  OG  . SER A 1 28  ? -22.083 -16.346 12.630  0.34 106.52 ? 291  SER A OG  1 
ATOM   158  N  N   . TRP A 1 29  ? -19.962 -13.005 9.999   0.34 106.84 ? 292  TRP A N   1 
ATOM   159  C  CA  . TRP A 1 29  ? -19.093 -12.536 8.885   0.34 108.79 ? 292  TRP A CA  1 
ATOM   160  C  C   . TRP A 1 29  ? -17.749 -12.058 9.445   0.34 108.99 ? 292  TRP A C   1 
ATOM   161  O  O   . TRP A 1 29  ? -17.735 -11.033 10.153  0.34 112.58 ? 292  TRP A O   1 
ATOM   162  C  CB  . TRP A 1 29  ? -19.787 -11.437 8.070   0.34 108.68 ? 292  TRP A CB  1 
ATOM   163  C  CG  . TRP A 1 29  ? -19.099 -11.120 6.776   0.34 109.19 ? 292  TRP A CG  1 
ATOM   164  C  CD1 . TRP A 1 29  ? -18.285 -10.055 6.515   0.34 110.12 ? 292  TRP A CD1 1 
ATOM   165  C  CD2 . TRP A 1 29  ? -19.159 -11.884 5.558   0.34 108.95 ? 292  TRP A CD2 1 
ATOM   166  N  NE1 . TRP A 1 29  ? -17.840 -10.101 5.221   0.34 109.96 ? 292  TRP A NE1 1 
ATOM   167  C  CE2 . TRP A 1 29  ? -18.359 -11.212 4.609   0.34 109.81 ? 292  TRP A CE2 1 
ATOM   168  C  CE3 . TRP A 1 29  ? -19.809 -13.063 5.177   0.34 107.38 ? 292  TRP A CE3 1 
ATOM   169  C  CZ2 . TRP A 1 29  ? -18.195 -11.684 3.307   0.34 108.28 ? 292  TRP A CZ2 1 
ATOM   170  C  CZ3 . TRP A 1 29  ? -19.646 -13.528 3.891   0.34 106.90 ? 292  TRP A CZ3 1 
ATOM   171  C  CH2 . TRP A 1 29  ? -18.850 -12.846 2.971   0.34 107.30 ? 292  TRP A CH2 1 
ATOM   172  N  N   . HIS A 1 30  ? -16.668 -12.779 9.132   0.34 107.45 ? 293  HIS A N   1 
ATOM   173  C  CA  . HIS A 1 30  ? -15.278 -12.460 9.551   0.34 107.27 ? 293  HIS A CA  1 
ATOM   174  C  C   . HIS A 1 30  ? -14.362 -12.431 8.324   0.34 107.64 ? 293  HIS A C   1 
ATOM   175  O  O   . HIS A 1 30  ? -14.491 -13.330 7.473   0.34 110.52 ? 293  HIS A O   1 
ATOM   176  C  CB  . HIS A 1 30  ? -14.794 -13.459 10.613  0.34 106.58 ? 293  HIS A CB  1 
ATOM   177  C  CG  . HIS A 1 30  ? -15.235 -14.867 10.385  0.34 105.89 ? 293  HIS A CG  1 
ATOM   178  N  ND1 . HIS A 1 30  ? -16.547 -15.269 10.558  0.34 105.50 ? 293  HIS A ND1 1 
ATOM   179  C  CD2 . HIS A 1 30  ? -14.545 -15.973 10.030  0.34 106.05 ? 293  HIS A CD2 1 
ATOM   180  C  CE1 . HIS A 1 30  ? -16.647 -16.558 10.305  0.34 104.34 ? 293  HIS A CE1 1 
ATOM   181  N  NE2 . HIS A 1 30  ? -15.432 -17.015 9.979   0.34 105.39 ? 293  HIS A NE2 1 
ATOM   182  N  N   . TYR A 1 31  ? -13.482 -11.428 8.239   0.34 107.28 ? 294  TYR A N   1 
ATOM   183  C  CA  . TYR A 1 31  ? -12.428 -11.309 7.198   0.34 108.24 ? 294  TYR A CA  1 
ATOM   184  C  C   . TYR A 1 31  ? -11.143 -11.967 7.710   0.34 107.70 ? 294  TYR A C   1 
ATOM   185  O  O   . TYR A 1 31  ? -10.143 -11.251 7.915   0.34 107.96 ? 294  TYR A O   1 
ATOM   186  C  CB  . TYR A 1 31  ? -12.177 -9.847  6.822   0.34 110.08 ? 294  TYR A CB  1 
ATOM   187  C  CG  . TYR A 1 31  ? -11.100 -9.654  5.784   0.34 114.86 ? 294  TYR A CG  1 
ATOM   188  C  CD1 . TYR A 1 31  ? -9.926  -8.981  6.083   0.34 116.34 ? 294  TYR A CD1 1 
ATOM   189  C  CD2 . TYR A 1 31  ? -11.244 -10.164 4.504   0.34 117.12 ? 294  TYR A CD2 1 
ATOM   190  C  CE1 . TYR A 1 31  ? -8.932  -8.805  5.135   0.34 116.18 ? 294  TYR A CE1 1 
ATOM   191  C  CE2 . TYR A 1 31  ? -10.259 -9.999  3.544   0.34 116.83 ? 294  TYR A CE2 1 
ATOM   192  C  CZ  . TYR A 1 31  ? -9.098  -9.317  3.861   0.34 116.29 ? 294  TYR A CZ  1 
ATOM   193  O  OH  . TYR A 1 31  ? -8.125  -9.151  2.919   0.34 117.08 ? 294  TYR A OH  1 
ATOM   194  N  N   . ASP A 1 32  ? -11.187 -13.290 7.900   1.00 107.06 ? 295  ASP A N   1 
ATOM   195  C  CA  . ASP A 1 32  ? -10.059 -14.118 8.427   1.00 109.73 ? 295  ASP A CA  1 
ATOM   196  C  C   . ASP A 1 32  ? -8.703  -13.695 7.830   1.00 116.31 ? 295  ASP A C   1 
ATOM   197  O  O   . ASP A 1 32  ? -8.620  -13.440 6.601   1.00 122.28 ? 295  ASP A O   1 
ATOM   198  C  CB  . ASP A 1 32  ? -10.349 -15.597 8.149   1.00 100.69 ? 295  ASP A CB  1 
ATOM   199  C  CG  . ASP A 1 32  ? -9.584  -16.567 9.021   1.00 98.22  ? 295  ASP A CG  1 
ATOM   200  O  OD1 . ASP A 1 32  ? -8.404  -16.281 9.315   1.00 93.10  ? 295  ASP A OD1 1 
ATOM   201  O  OD2 . ASP A 1 32  ? -10.183 -17.596 9.399   1.00 100.24 ? 295  ASP A OD2 1 
ATOM   202  N  N   . GLN A 1 33  ? -7.671  -13.637 8.681   0.34 114.92 ? 296  GLN A N   1 
ATOM   203  C  CA  . GLN A 1 33  ? -6.291  -13.206 8.324   0.34 114.85 ? 296  GLN A CA  1 
ATOM   204  C  C   . GLN A 1 33  ? -5.389  -14.440 8.195   0.34 111.83 ? 296  GLN A C   1 
ATOM   205  O  O   . GLN A 1 33  ? -4.201  -14.268 7.852   0.34 109.95 ? 296  GLN A O   1 
ATOM   206  C  CB  . GLN A 1 33  ? -5.748  -12.240 9.379   0.34 116.16 ? 296  GLN A CB  1 
ATOM   207  C  CG  . GLN A 1 33  ? -6.589  -10.982 9.546   0.34 116.87 ? 296  GLN A CG  1 
ATOM   208  C  CD  . GLN A 1 33  ? -6.528  -10.088 8.332   0.34 117.74 ? 296  GLN A CD  1 
ATOM   209  O  OE1 . GLN A 1 33  ? -5.983  -10.456 7.294   0.34 118.76 ? 296  GLN A OE1 1 
ATOM   210  N  NE2 . GLN A 1 33  ? -7.091  -8.897  8.455   0.34 118.65 ? 296  GLN A NE2 1 
ATOM   211  N  N   . ASP A 1 34  ? -5.937  -15.630 8.464   0.34 108.14 ? 297  ASP A N   1 
ATOM   212  C  CA  . ASP A 1 34  ? -5.225  -16.932 8.364   0.34 106.24 ? 297  ASP A CA  1 
ATOM   213  C  C   . ASP A 1 34  ? -5.826  -17.752 7.215   0.34 104.74 ? 297  ASP A C   1 
ATOM   214  O  O   . ASP A 1 34  ? -5.858  -18.993 7.335   0.34 106.38 ? 297  ASP A O   1 
ATOM   215  C  CB  . ASP A 1 34  ? -5.293  -17.712 9.681   0.34 105.57 ? 297  ASP A CB  1 
ATOM   216  C  CG  . ASP A 1 34  ? -4.436  -17.133 10.796  0.34 105.74 ? 297  ASP A CG  1 
ATOM   217  O  OD1 . ASP A 1 34  ? -4.381  -15.891 10.912  0.34 105.34 ? 297  ASP A OD1 1 
ATOM   218  O  OD2 . ASP A 1 34  ? -3.828  -17.930 11.539  0.34 104.08 ? 297  ASP A OD2 1 
ATOM   219  N  N   . HIS A 1 35  ? -6.278  -17.083 6.147   0.34 101.13 ? 298  HIS A N   1 
ATOM   220  C  CA  . HIS A 1 35  ? -6.897  -17.711 4.947   0.34 96.09  ? 298  HIS A CA  1 
ATOM   221  C  C   . HIS A 1 35  ? -5.804  -18.299 4.057   0.34 92.73  ? 298  HIS A C   1 
ATOM   222  O  O   . HIS A 1 35  ? -4.809  -17.633 3.778   0.34 92.45  ? 298  HIS A O   1 
ATOM   223  C  CB  . HIS A 1 35  ? -7.780  -16.701 4.197   0.34 95.86  ? 298  HIS A CB  1 
ATOM   224  C  CG  . HIS A 1 35  ? -7.039  -15.551 3.598   0.34 95.06  ? 298  HIS A CG  1 
ATOM   225  N  ND1 . HIS A 1 35  ? -7.132  -14.268 4.105   0.34 96.00  ? 298  HIS A ND1 1 
ATOM   226  C  CD2 . HIS A 1 35  ? -6.215  -15.474 2.530   0.34 93.69  ? 298  HIS A CD2 1 
ATOM   227  C  CE1 . HIS A 1 35  ? -6.391  -13.455 3.380   0.34 95.09  ? 298  HIS A CE1 1 
ATOM   228  N  NE2 . HIS A 1 35  ? -5.816  -14.170 2.408   0.34 93.70  ? 298  HIS A NE2 1 
ATOM   229  N  N   . PRO A 1 36  ? -5.956  -19.556 3.575   1.00 87.56  ? 299  PRO A N   1 
ATOM   230  C  CA  . PRO A 1 36  ? -4.895  -20.221 2.812   1.00 82.94  ? 299  PRO A CA  1 
ATOM   231  C  C   . PRO A 1 36  ? -4.712  -19.882 1.322   1.00 92.49  ? 299  PRO A C   1 
ATOM   232  O  O   . PRO A 1 36  ? -3.937  -20.565 0.670   1.00 91.48  ? 299  PRO A O   1 
ATOM   233  C  CB  . PRO A 1 36  ? -5.362  -21.682 2.905   1.00 85.55  ? 299  PRO A CB  1 
ATOM   234  C  CG  . PRO A 1 36  ? -6.864  -21.579 2.859   1.00 85.83  ? 299  PRO A CG  1 
ATOM   235  C  CD  . PRO A 1 36  ? -7.154  -20.393 3.750   1.00 87.25  ? 299  PRO A CD  1 
ATOM   236  N  N   . TYR A 1 37  ? -5.406  -18.864 0.806   1.00 92.81  ? 300  TYR A N   1 
ATOM   237  C  CA  . TYR A 1 37  ? -5.447  -18.527 -0.641  1.00 87.38  ? 300  TYR A CA  1 
ATOM   238  C  C   . TYR A 1 37  ? -4.316  -17.558 -0.977  1.00 87.38  ? 300  TYR A C   1 
ATOM   239  O  O   . TYR A 1 37  ? -4.173  -16.545 -0.264  1.00 85.95  ? 300  TYR A O   1 
ATOM   240  C  CB  . TYR A 1 37  ? -6.823  -17.968 -1.011  1.00 82.03  ? 300  TYR A CB  1 
ATOM   241  C  CG  . TYR A 1 37  ? -7.941  -18.802 -0.453  1.00 72.00  ? 300  TYR A CG  1 
ATOM   242  C  CD1 . TYR A 1 37  ? -8.313  -19.989 -1.055  1.00 72.60  ? 300  TYR A CD1 1 
ATOM   243  C  CD2 . TYR A 1 37  ? -8.558  -18.459 0.734   1.00 70.85  ? 300  TYR A CD2 1 
ATOM   244  C  CE1 . TYR A 1 37  ? -9.295  -20.800 -0.508  1.00 68.68  ? 300  TYR A CE1 1 
ATOM   245  C  CE2 . TYR A 1 37  ? -9.547  -19.253 1.290   1.00 62.88  ? 300  TYR A CE2 1 
ATOM   246  C  CZ  . TYR A 1 37  ? -9.920  -20.424 0.665   1.00 60.15  ? 300  TYR A CZ  1 
ATOM   247  O  OH  . TYR A 1 37  ? -10.886 -21.210 1.213   1.00 68.76  ? 300  TYR A OH  1 
ATOM   248  N  N   . LYS A 1 38  ? -3.549  -17.871 -2.030  1.00 90.46  ? 301  LYS A N   1 
ATOM   249  C  CA  . LYS A 1 38  ? -2.554  -16.946 -2.647  1.00 90.99  ? 301  LYS A CA  1 
ATOM   250  C  C   . LYS A 1 38  ? -3.037  -16.448 -4.021  1.00 84.48  ? 301  LYS A C   1 
ATOM   251  O  O   . LYS A 1 38  ? -3.061  -15.222 -4.242  1.00 83.34  ? 301  LYS A O   1 
ATOM   252  C  CB  . LYS A 1 38  ? -1.175  -17.606 -2.796  1.00 95.63  ? 301  LYS A CB  1 
ATOM   253  C  CG  . LYS A 1 38  ? -0.102  -16.746 -3.469  1.00 98.92  ? 301  LYS A CG  1 
ATOM   254  C  CD  . LYS A 1 38  ? 0.174   -15.408 -2.782  1.00 101.15 ? 301  LYS A CD  1 
ATOM   255  C  CE  . LYS A 1 38  ? 0.872   -14.396 -3.672  1.00 105.14 ? 301  LYS A CE  1 
ATOM   256  N  NZ  . LYS A 1 38  ? 2.348   -14.460 -3.546  1.00 105.01 ? 301  LYS A NZ  1 
ATOM   257  N  N   . THR A 1 39  ? -3.395  -17.379 -4.913  0.34 81.24  ? 302  THR A N   1 
ATOM   258  C  CA  . THR A 1 39  ? -3.770  -17.115 -6.330  0.34 77.71  ? 302  THR A CA  1 
ATOM   259  C  C   . THR A 1 39  ? -5.277  -16.854 -6.432  0.34 74.27  ? 302  THR A C   1 
ATOM   260  O  O   . THR A 1 39  ? -5.722  -16.398 -7.504  0.34 72.97  ? 302  THR A O   1 
ATOM   261  C  CB  . THR A 1 39  ? -3.359  -18.284 -7.231  0.34 75.99  ? 302  THR A CB  1 
ATOM   262  O  OG1 . THR A 1 39  ? -4.289  -19.343 -7.006  0.34 75.99  ? 302  THR A OG1 1 
ATOM   263  C  CG2 . THR A 1 39  ? -1.947  -18.762 -6.970  0.34 76.10  ? 302  THR A CG2 1 
ATOM   264  N  N   . TRP A 1 40  ? -6.031  -17.181 -5.380  0.34 69.64  ? 303  TRP A N   1 
ATOM   265  C  CA  . TRP A 1 40  ? -7.488  -16.896 -5.359  0.34 66.58  ? 303  TRP A CA  1 
ATOM   266  C  C   . TRP A 1 40  ? -7.721  -15.647 -4.508  0.34 67.35  ? 303  TRP A C   1 
ATOM   267  O  O   . TRP A 1 40  ? -7.020  -15.498 -3.491  0.34 67.99  ? 303  TRP A O   1 
ATOM   268  C  CB  . TRP A 1 40  ? -8.265  -18.093 -4.803  0.34 64.04  ? 303  TRP A CB  1 
ATOM   269  C  CG  . TRP A 1 40  ? -8.455  -19.217 -5.772  0.34 60.65  ? 303  TRP A CG  1 
ATOM   270  C  CD1 . TRP A 1 40  ? -7.511  -20.103 -6.203  0.34 58.95  ? 303  TRP A CD1 1 
ATOM   271  C  CD2 . TRP A 1 40  ? -9.681  -19.589 -6.424  0.34 60.32  ? 303  TRP A CD2 1 
ATOM   272  N  NE1 . TRP A 1 40  ? -8.063  -20.995 -7.082  0.34 58.58  ? 303  TRP A NE1 1 
ATOM   273  C  CE2 . TRP A 1 40  ? -9.393  -20.706 -7.236  0.34 60.01  ? 303  TRP A CE2 1 
ATOM   274  C  CE3 . TRP A 1 40  ? -10.987 -19.089 -6.403  0.34 58.98  ? 303  TRP A CE3 1 
ATOM   275  C  CZ2 . TRP A 1 40  ? -10.366 -21.327 -8.016  0.34 59.72  ? 303  TRP A CZ2 1 
ATOM   276  C  CZ3 . TRP A 1 40  ? -11.947 -19.703 -7.175  0.34 58.38  ? 303  TRP A CZ3 1 
ATOM   277  C  CH2 . TRP A 1 40  ? -11.638 -20.807 -7.970  0.34 58.74  ? 303  TRP A CH2 1 
ATOM   278  N  N   . ALA A 1 41  ? -8.661  -14.789 -4.906  0.34 67.42  ? 304  ALA A N   1 
ATOM   279  C  CA  . ALA A 1 41  ? -8.987  -13.592 -4.097  0.34 67.02  ? 304  ALA A CA  1 
ATOM   280  C  C   . ALA A 1 41  ? -9.983  -13.978 -3.000  0.34 67.69  ? 304  ALA A C   1 
ATOM   281  O  O   . ALA A 1 41  ? -11.017 -14.580 -3.332  0.34 66.92  ? 304  ALA A O   1 
ATOM   282  C  CB  . ALA A 1 41  ? -9.527  -12.498 -4.980  0.34 66.14  ? 304  ALA A CB  1 
ATOM   283  N  N   . TYR A 1 42  ? -9.672  -13.646 -1.745  0.34 69.54  ? 305  TYR A N   1 
ATOM   284  C  CA  . TYR A 1 42  ? -10.556 -13.985 -0.599  0.34 69.52  ? 305  TYR A CA  1 
ATOM   285  C  C   . TYR A 1 42  ? -11.353 -12.737 -0.218  0.34 70.92  ? 305  TYR A C   1 
ATOM   286  O  O   . TYR A 1 42  ? -10.766 -11.640 -0.210  0.34 71.08  ? 305  TYR A O   1 
ATOM   287  C  CB  . TYR A 1 42  ? -9.721  -14.511 0.570   0.34 68.59  ? 305  TYR A CB  1 
ATOM   288  C  CG  . TYR A 1 42  ? -10.379 -14.431 1.923   0.34 68.81  ? 305  TYR A CG  1 
ATOM   289  C  CD1 . TYR A 1 42  ? -11.303 -15.381 2.321   0.34 68.96  ? 305  TYR A CD1 1 
ATOM   290  C  CD2 . TYR A 1 42  ? -10.069 -13.415 2.811   0.34 69.74  ? 305  TYR A CD2 1 
ATOM   291  C  CE1 . TYR A 1 42  ? -11.909 -15.317 3.564   0.34 69.67  ? 305  TYR A CE1 1 
ATOM   292  C  CE2 . TYR A 1 42  ? -10.665 -13.339 4.058   0.34 69.62  ? 305  TYR A CE2 1 
ATOM   293  C  CZ  . TYR A 1 42  ? -11.589 -14.295 4.437   0.34 70.67  ? 305  TYR A CZ  1 
ATOM   294  O  OH  . TYR A 1 42  ? -12.188 -14.233 5.661   0.34 73.09  ? 305  TYR A OH  1 
ATOM   295  N  N   . HIS A 1 43  ? -12.644 -12.895 0.080   0.34 72.12  ? 306  HIS A N   1 
ATOM   296  C  CA  . HIS A 1 43  ? -13.491 -11.704 0.355   0.34 73.02  ? 306  HIS A CA  1 
ATOM   297  C  C   . HIS A 1 43  ? -14.051 -11.753 1.781   0.34 74.87  ? 306  HIS A C   1 
ATOM   298  O  O   . HIS A 1 43  ? -14.301 -10.673 2.344   0.34 78.30  ? 306  HIS A O   1 
ATOM   299  C  CB  . HIS A 1 43  ? -14.596 -11.595 -0.703  0.34 71.26  ? 306  HIS A CB  1 
ATOM   300  C  CG  . HIS A 1 43  ? -14.077 -11.435 -2.091  0.34 68.91  ? 306  HIS A CG  1 
ATOM   301  N  ND1 . HIS A 1 43  ? -13.661 -10.216 -2.585  0.34 68.06  ? 306  HIS A ND1 1 
ATOM   302  C  CD2 . HIS A 1 43  ? -13.902 -12.328 -3.088  0.34 68.39  ? 306  HIS A CD2 1 
ATOM   303  C  CE1 . HIS A 1 43  ? -13.253 -10.364 -3.829  0.34 67.61  ? 306  HIS A CE1 1 
ATOM   304  N  NE2 . HIS A 1 43  ? -13.392 -11.651 -4.160  0.34 67.79  ? 306  HIS A NE2 1 
ATOM   305  N  N   . GLY A 1 44  ? -14.249 -12.952 2.334   1.00 74.64  ? 307  GLY A N   1 
ATOM   306  C  CA  . GLY A 1 44  ? -14.849 -13.061 3.674   1.00 72.25  ? 307  GLY A CA  1 
ATOM   307  C  C   . GLY A 1 44  ? -15.216 -14.481 4.044   1.00 75.38  ? 307  GLY A C   1 
ATOM   308  O  O   . GLY A 1 44  ? -14.900 -15.386 3.258   1.00 76.71  ? 307  GLY A O   1 
ATOM   309  N  N   . SER A 1 45  ? -15.868 -14.668 5.196   1.00 77.44  ? 308  SER A N   1 
ATOM   310  C  CA  . SER A 1 45  ? -16.208 -16.029 5.681   1.00 84.94  ? 308  SER A CA  1 
ATOM   311  C  C   . SER A 1 45  ? -17.461 -15.995 6.556   1.00 88.50  ? 308  SER A C   1 
ATOM   312  O  O   . SER A 1 45  ? -17.812 -14.899 7.010   1.00 92.21  ? 308  SER A O   1 
ATOM   313  C  CB  . SER A 1 45  ? -15.055 -16.633 6.434   1.00 89.44  ? 308  SER A CB  1 
ATOM   314  O  OG  . SER A 1 45  ? -13.821 -16.352 5.790   1.00 92.97  ? 308  SER A OG  1 
ATOM   315  N  N   . TYR A 1 46  ? -18.096 -17.150 6.780   0.34 92.03  ? 309  TYR A N   1 
ATOM   316  C  CA  . TYR A 1 46  ? -19.329 -17.259 7.606   0.34 94.64  ? 309  TYR A CA  1 
ATOM   317  C  C   . TYR A 1 46  ? -19.535 -18.724 8.020   0.34 98.56  ? 309  TYR A C   1 
ATOM   318  O  O   . TYR A 1 46  ? -19.085 -19.626 7.287   0.34 100.50 ? 309  TYR A O   1 
ATOM   319  C  CB  . TYR A 1 46  ? -20.536 -16.694 6.848   0.34 93.95  ? 309  TYR A CB  1 
ATOM   320  C  CG  . TYR A 1 46  ? -20.934 -17.458 5.609   0.34 92.08  ? 309  TYR A CG  1 
ATOM   321  C  CD1 . TYR A 1 46  ? -21.734 -18.585 5.693   0.34 91.94  ? 309  TYR A CD1 1 
ATOM   322  C  CD2 . TYR A 1 46  ? -20.526 -17.048 4.350   0.34 90.76  ? 309  TYR A CD2 1 
ATOM   323  C  CE1 . TYR A 1 46  ? -22.110 -19.292 4.562   0.34 92.45  ? 309  TYR A CE1 1 
ATOM   324  C  CE2 . TYR A 1 46  ? -20.893 -17.743 3.209   0.34 90.82  ? 309  TYR A CE2 1 
ATOM   325  C  CZ  . TYR A 1 46  ? -21.688 -18.870 3.315   0.34 91.62  ? 309  TYR A CZ  1 
ATOM   326  O  OH  . TYR A 1 46  ? -22.057 -19.564 2.199   0.34 91.58  ? 309  TYR A OH  1 
ATOM   327  N  N   . GLU A 1 47  ? -20.193 -18.945 9.163   0.34 103.16 ? 310  GLU A N   1 
ATOM   328  C  CA  . GLU A 1 47  ? -20.393 -20.284 9.784   0.34 109.06 ? 310  GLU A CA  1 
ATOM   329  C  C   . GLU A 1 47  ? -21.102 -21.217 8.793   0.34 112.09 ? 310  GLU A C   1 
ATOM   330  O  O   . GLU A 1 47  ? -21.883 -20.713 7.963   0.34 116.52 ? 310  GLU A O   1 
ATOM   331  C  CB  . GLU A 1 47  ? -21.195 -20.158 11.082  0.34 112.41 ? 310  GLU A CB  1 
ATOM   332  C  CG  . GLU A 1 47  ? -21.498 -21.496 11.737  0.34 114.30 ? 310  GLU A CG  1 
ATOM   333  C  CD  . GLU A 1 47  ? -22.066 -21.413 13.144  0.34 116.64 ? 310  GLU A CD  1 
ATOM   334  O  OE1 . GLU A 1 47  ? -22.406 -20.295 13.582  0.34 117.00 ? 310  GLU A OE1 1 
ATOM   335  O  OE2 . GLU A 1 47  ? -22.165 -22.471 13.801  0.34 118.80 ? 310  GLU A OE2 1 
ATOM   336  N  N   . THR A 1 48  ? -20.830 -22.524 8.889   0.34 114.38 ? 311  THR A N   1 
ATOM   337  C  CA  . THR A 1 48  ? -21.449 -23.603 8.069   0.34 114.63 ? 311  THR A CA  1 
ATOM   338  C  C   . THR A 1 48  ? -21.365 -24.932 8.829   0.34 115.12 ? 311  THR A C   1 
ATOM   339  O  O   . THR A 1 48  ? -21.954 -25.912 8.326   0.34 115.25 ? 311  THR A O   1 
ATOM   340  C  CB  . THR A 1 48  ? -20.784 -23.710 6.690   0.34 115.24 ? 311  THR A CB  1 
ATOM   341  O  OG1 . THR A 1 48  ? -19.372 -23.574 6.859   0.34 116.69 ? 311  THR A OG1 1 
ATOM   342  C  CG2 . THR A 1 48  ? -21.280 -22.667 5.713   0.34 115.69 ? 311  THR A CG2 1 
ATOM   343  N  N   . ALA A 1 54  ? -21.147 -37.953 0.404   1.00 133.80 ? 317  ALA A N   1 
ATOM   344  C  CA  . ALA A 1 54  ? -21.787 -38.962 -0.478  1.00 132.25 ? 317  ALA A CA  1 
ATOM   345  C  C   . ALA A 1 54  ? -20.739 -39.983 -0.943  1.00 135.21 ? 317  ALA A C   1 
ATOM   346  O  O   . ALA A 1 54  ? -20.585 -40.164 -2.170  1.00 137.76 ? 317  ALA A O   1 
ATOM   347  C  CB  . ALA A 1 54  ? -22.458 -38.279 -1.648  1.00 127.38 ? 317  ALA A CB  1 
ATOM   348  N  N   . SER A 1 55  ? -20.069 -40.644 0.011   1.00 132.54 ? 318  SER A N   1 
ATOM   349  C  CA  . SER A 1 55  ? -18.909 -41.548 -0.225  1.00 118.17 ? 318  SER A CA  1 
ATOM   350  C  C   . SER A 1 55  ? -19.334 -42.760 -1.068  1.00 102.35 ? 318  SER A C   1 
ATOM   351  O  O   . SER A 1 55  ? -20.556 -42.969 -1.283  1.00 97.56  ? 318  SER A O   1 
ATOM   352  C  CB  . SER A 1 55  ? -18.243 -41.971 1.077   1.00 114.15 ? 318  SER A CB  1 
ATOM   353  O  OG  . SER A 1 55  ? -18.859 -43.123 1.638   1.00 108.78 ? 318  SER A OG  1 
ATOM   354  N  N   . SER A 1 56  ? -18.342 -43.517 -1.536  1.00 86.72  ? 319  SER A N   1 
ATOM   355  C  CA  . SER A 1 56  ? -18.503 -44.723 -2.384  1.00 81.57  ? 319  SER A CA  1 
ATOM   356  C  C   . SER A 1 56  ? -18.938 -45.904 -1.502  1.00 72.60  ? 319  SER A C   1 
ATOM   357  O  O   . SER A 1 56  ? -18.289 -46.154 -0.477  1.00 64.85  ? 319  SER A O   1 
ATOM   358  C  CB  . SER A 1 56  ? -17.229 -45.023 -3.155  1.00 88.52  ? 319  SER A CB  1 
ATOM   359  O  OG  . SER A 1 56  ? -16.409 -45.971 -2.473  1.00 81.84  ? 319  SER A OG  1 
ATOM   360  N  N   . MET A 1 57  ? -20.002 -46.604 -1.908  1.00 63.02  ? 320  MET A N   1 
ATOM   361  C  CA  . MET A 1 57  ? -20.551 -47.819 -1.246  1.00 51.63  ? 320  MET A CA  1 
ATOM   362  C  C   . MET A 1 57  ? -20.314 -49.028 -2.162  1.00 42.81  ? 320  MET A C   1 
ATOM   363  O  O   . MET A 1 57  ? -20.064 -48.836 -3.371  1.00 40.39  ? 320  MET A O   1 
ATOM   364  C  CB  . MET A 1 57  ? -22.044 -47.605 -1.004  1.00 57.56  ? 320  MET A CB  1 
ATOM   365  C  CG  . MET A 1 57  ? -22.372 -46.165 -0.566  1.00 60.26  ? 320  MET A CG  1 
ATOM   366  S  SD  . MET A 1 57  ? -21.687 -45.797 1.084   1.00 62.00  ? 320  MET A SD  1 
ATOM   367  C  CE  . MET A 1 57  ? -22.764 -46.815 2.095   1.00 60.63  ? 320  MET A CE  1 
ATOM   368  N  N   . VAL A 1 58  ? -20.334 -50.239 -1.631  1.00 33.72  ? 321  VAL A N   1 
ATOM   369  C  CA  . VAL A 1 58  ? -20.180 -51.442 -2.488  1.00 34.99  ? 321  VAL A CA  1 
ATOM   370  C  C   . VAL A 1 58  ? -21.561 -51.925 -2.943  1.00 33.39  ? 321  VAL A C   1 
ATOM   371  O  O   . VAL A 1 58  ? -22.453 -51.977 -2.099  1.00 34.00  ? 321  VAL A O   1 
ATOM   372  C  CB  . VAL A 1 58  ? -19.413 -52.553 -1.763  1.00 37.38  ? 321  VAL A CB  1 
ATOM   373  C  CG1 . VAL A 1 58  ? -19.340 -53.821 -2.598  1.00 36.83  ? 321  VAL A CG1 1 
ATOM   374  C  CG2 . VAL A 1 58  ? -18.036 -52.079 -1.376  1.00 40.40  ? 321  VAL A CG2 1 
ATOM   375  N  N   . ASN A 1 59  ? -21.675 -52.252 -4.235  1.00 27.12  ? 322  ASN A N   1 
ATOM   376  C  CA  . ASN A 1 59  ? -22.766 -53.023 -4.863  1.00 28.87  ? 322  ASN A CA  1 
ATOM   377  C  C   . ASN A 1 59  ? -22.609 -54.503 -4.512  1.00 30.18  ? 322  ASN A C   1 
ATOM   378  O  O   . ASN A 1 59  ? -21.731 -55.183 -5.085  1.00 30.51  ? 322  ASN A O   1 
ATOM   379  C  CB  . ASN A 1 59  ? -22.741 -52.781 -6.377  1.00 30.16  ? 322  ASN A CB  1 
ATOM   380  C  CG  . ASN A 1 59  ? -23.954 -53.365 -7.077  1.00 30.74  ? 322  ASN A CG  1 
ATOM   381  O  OD1 . ASN A 1 59  ? -24.340 -54.506 -6.812  1.00 28.69  ? 322  ASN A OD1 1 
ATOM   382  N  ND2 . ASN A 1 59  ? -24.561 -52.592 -7.962  1.00 32.15  ? 322  ASN A ND2 1 
ATOM   383  N  N   . GLY A 1 60  ? -23.480 -55.018 -3.655  1.00 32.67  ? 323  GLY A N   1 
ATOM   384  C  CA  . GLY A 1 60  ? -23.429 -56.402 -3.158  1.00 27.69  ? 323  GLY A CA  1 
ATOM   385  C  C   . GLY A 1 60  ? -23.774 -57.406 -4.249  1.00 33.27  ? 323  GLY A C   1 
ATOM   386  O  O   . GLY A 1 60  ? -23.221 -58.547 -4.267  1.00 33.40  ? 323  GLY A O   1 
ATOM   387  N  N   . VAL A 1 61  ? -24.625 -57.021 -5.192  1.00 31.29  ? 324  VAL A N   1 
ATOM   388  C  CA  . VAL A 1 61  ? -25.015 -57.960 -6.269  1.00 28.86  ? 324  VAL A CA  1 
ATOM   389  C  C   . VAL A 1 61  ? -23.764 -58.270 -7.091  1.00 28.07  ? 324  VAL A C   1 
ATOM   390  O  O   . VAL A 1 61  ? -23.444 -59.457 -7.213  1.00 28.47  ? 324  VAL A O   1 
ATOM   391  C  CB  . VAL A 1 61  ? -26.220 -57.432 -7.058  1.00 30.19  ? 324  VAL A CB  1 
ATOM   392  C  CG1 . VAL A 1 61  ? -26.502 -58.261 -8.289  1.00 29.37  ? 324  VAL A CG1 1 
ATOM   393  C  CG2 . VAL A 1 61  ? -27.451 -57.401 -6.150  1.00 29.16  ? 324  VAL A CG2 1 
ATOM   394  N  N   . VAL A 1 62  ? -23.028 -57.253 -7.546  1.00 30.30  ? 325  VAL A N   1 
ATOM   395  C  CA  . VAL A 1 62  ? -21.792 -57.432 -8.365  1.00 31.19  ? 325  VAL A CA  1 
ATOM   396  C  C   . VAL A 1 62  ? -20.728 -58.152 -7.526  1.00 28.44  ? 325  VAL A C   1 
ATOM   397  O  O   . VAL A 1 62  ? -20.141 -59.098 -8.038  1.00 27.18  ? 325  VAL A O   1 
ATOM   398  C  CB  . VAL A 1 62  ? -21.243 -56.110 -8.926  1.00 29.61  ? 325  VAL A CB  1 
ATOM   399  C  CG1 . VAL A 1 62  ? -19.944 -56.362 -9.676  1.00 28.15  ? 325  VAL A CG1 1 
ATOM   400  C  CG2 . VAL A 1 62  ? -22.261 -55.435 -9.826  1.00 28.35  ? 325  VAL A CG2 1 
ATOM   401  N  N   . ARG A 1 63  ? -20.563 -57.787 -6.258  1.00 27.76  ? 326  ARG A N   1 
ATOM   402  C  CA  . ARG A 1 63  ? -19.471 -58.363 -5.449  1.00 29.81  ? 326  ARG A CA  1 
ATOM   403  C  C   . ARG A 1 63  ? -19.742 -59.852 -5.180  1.00 30.72  ? 326  ARG A C   1 
ATOM   404  O  O   . ARG A 1 63  ? -18.784 -60.643 -5.312  1.00 30.16  ? 326  ARG A O   1 
ATOM   405  C  CB  . ARG A 1 63  ? -19.185 -57.544 -4.198  1.00 30.05  ? 326  ARG A CB  1 
ATOM   406  C  CG  . ARG A 1 63  ? -18.186 -58.226 -3.274  1.00 28.60  ? 326  ARG A CG  1 
ATOM   407  C  CD  . ARG A 1 63  ? -17.499 -57.282 -2.322  1.00 28.06  ? 326  ARG A CD  1 
ATOM   408  N  NE  . ARG A 1 63  ? -18.374 -56.794 -1.276  1.00 30.10  ? 326  ARG A NE  1 
ATOM   409  C  CZ  . ARG A 1 63  ? -17.988 -56.014 -0.272  1.00 29.62  ? 326  ARG A CZ  1 
ATOM   410  N  NH1 . ARG A 1 63  ? -16.707 -55.687 -0.127  1.00 30.07  ? 326  ARG A NH1 1 
ATOM   411  N  NH2 . ARG A 1 63  ? -18.889 -55.565 0.588   1.00 29.92  ? 326  ARG A NH2 1 
ATOM   412  N  N   . LEU A 1 64  ? -20.968 -60.276 -4.882  1.00 29.22  ? 327  LEU A N   1 
ATOM   413  C  CA  . LEU A 1 64  ? -21.230 -61.712 -4.573  1.00 27.14  ? 327  LEU A CA  1 
ATOM   414  C  C   . LEU A 1 64  ? -20.982 -62.540 -5.834  1.00 25.05  ? 327  LEU A C   1 
ATOM   415  O  O   . LEU A 1 64  ? -20.680 -63.733 -5.715  1.00 30.01  ? 327  LEU A O   1 
ATOM   416  C  CB  . LEU A 1 64  ? -22.664 -61.909 -4.054  1.00 28.31  ? 327  LEU A CB  1 
ATOM   417  C  CG  . LEU A 1 64  ? -22.887 -61.541 -2.581  1.00 30.52  ? 327  LEU A CG  1 
ATOM   418  C  CD1 . LEU A 1 64  ? -24.358 -61.711 -2.178  1.00 33.56  ? 327  LEU A CD1 1 
ATOM   419  C  CD2 . LEU A 1 64  ? -22.032 -62.376 -1.644  1.00 30.32  ? 327  LEU A CD2 1 
ATOM   420  N  N   . LEU A 1 65  ? -21.088 -61.945 -7.018  1.00 27.26  ? 328  LEU A N   1 
ATOM   421  C  CA  . LEU A 1 65  ? -20.923 -62.694 -8.304  1.00 26.83  ? 328  LEU A CA  1 
ATOM   422  C  C   . LEU A 1 65  ? -19.505 -62.524 -8.885  1.00 26.49  ? 328  LEU A C   1 
ATOM   423  O  O   . LEU A 1 65  ? -19.266 -63.061 -9.988  1.00 25.99  ? 328  LEU A O   1 
ATOM   424  C  CB  . LEU A 1 65  ? -22.023 -62.245 -9.268  1.00 28.58  ? 328  LEU A CB  1 
ATOM   425  C  CG  . LEU A 1 65  ? -23.439 -62.625 -8.800  1.00 29.48  ? 328  LEU A CG  1 
ATOM   426  C  CD1 . LEU A 1 65  ? -24.516 -62.042 -9.687  1.00 29.87  ? 328  LEU A CD1 1 
ATOM   427  C  CD2 . LEU A 1 65  ? -23.608 -64.127 -8.723  1.00 31.97  ? 328  LEU A CD2 1 
ATOM   428  N  N   . THR A 1 66  ? -18.590 -61.877 -8.153  1.00 24.04  ? 329  THR A N   1 
ATOM   429  C  CA  . THR A 1 66  ? -17.168 -61.709 -8.558  1.00 24.51  ? 329  THR A CA  1 
ATOM   430  C  C   . THR A 1 66  ? -16.236 -62.066 -7.376  1.00 25.52  ? 329  THR A C   1 
ATOM   431  O  O   . THR A 1 66  ? -15.223 -61.345 -7.133  1.00 29.34  ? 329  THR A O   1 
ATOM   432  C  CB  . THR A 1 66  ? -16.925 -60.290 -9.111  1.00 25.00  ? 329  THR A CB  1 
ATOM   433  O  OG1 . THR A 1 66  ? -17.352 -59.301 -8.162  1.00 22.68  ? 329  THR A OG1 1 
ATOM   434  C  CG2 . THR A 1 66  ? -17.598 -60.070 -10.448 1.00 25.15  ? 329  THR A CG2 1 
ATOM   435  N  N   . LYS A 1 67  ? -16.465 -63.196 -6.727  1.00 23.42  ? 330  LYS A N   1 
ATOM   436  C  CA  . LYS A 1 67  ? -15.766 -63.612 -5.483  1.00 26.67  ? 330  LYS A CA  1 
ATOM   437  C  C   . LYS A 1 67  ? -14.242 -63.705 -5.672  1.00 25.82  ? 330  LYS A C   1 
ATOM   438  O  O   . LYS A 1 67  ? -13.512 -63.280 -4.787  1.00 26.70  ? 330  LYS A O   1 
ATOM   439  C  CB  . LYS A 1 67  ? -16.303 -64.956 -4.983  1.00 29.98  ? 330  LYS A CB  1 
ATOM   440  C  CG  . LYS A 1 67  ? -15.907 -65.283 -3.557  1.00 30.70  ? 330  LYS A CG  1 
ATOM   441  C  CD  . LYS A 1 67  ? -16.244 -66.674 -3.144  1.00 35.57  ? 330  LYS A CD  1 
ATOM   442  C  CE  . LYS A 1 67  ? -16.345 -66.756 -1.635  1.00 40.35  ? 330  LYS A CE  1 
ATOM   443  N  NZ  . LYS A 1 67  ? -16.306 -68.160 -1.190  1.00 44.72  ? 330  LYS A NZ  1 
ATOM   444  N  N   . PRO A 1 68  ? -13.687 -64.226 -6.775  1.00 25.32  ? 331  PRO A N   1 
ATOM   445  C  CA  . PRO A 1 68  ? -12.227 -64.321 -6.914  1.00 29.36  ? 331  PRO A CA  1 
ATOM   446  C  C   . PRO A 1 68  ? -11.540 -62.960 -6.688  1.00 31.61  ? 331  PRO A C   1 
ATOM   447  O  O   . PRO A 1 68  ? -10.389 -62.908 -6.241  1.00 26.05  ? 331  PRO A O   1 
ATOM   448  C  CB  . PRO A 1 68  ? -12.018 -64.807 -8.353  1.00 28.93  ? 331  PRO A CB  1 
ATOM   449  C  CG  . PRO A 1 68  ? -13.270 -65.617 -8.606  1.00 30.49  ? 331  PRO A CG  1 
ATOM   450  C  CD  . PRO A 1 68  ? -14.384 -64.829 -7.918  1.00 29.21  ? 331  PRO A CD  1 
ATOM   451  N  N   . TRP A 1 69  ? -12.265 -61.864 -6.935  1.00 28.04  ? 332  TRP A N   1 
ATOM   452  C  CA  . TRP A 1 69  ? -11.661 -60.512 -6.878  1.00 27.62  ? 332  TRP A CA  1 
ATOM   453  C  C   . TRP A 1 69  ? -11.680 -60.000 -5.435  1.00 28.17  ? 332  TRP A C   1 
ATOM   454  O  O   . TRP A 1 69  ? -11.063 -58.976 -5.150  1.00 31.92  ? 332  TRP A O   1 
ATOM   455  C  CB  . TRP A 1 69  ? -12.325 -59.618 -7.934  1.00 29.70  ? 332  TRP A CB  1 
ATOM   456  C  CG  . TRP A 1 69  ? -11.920 -60.026 -9.322  1.00 28.17  ? 332  TRP A CG  1 
ATOM   457  C  CD1 . TRP A 1 69  ? -10.824 -59.571 -9.991  1.00 27.64  ? 332  TRP A CD1 1 
ATOM   458  C  CD2 . TRP A 1 69  ? -12.517 -61.027 -10.173 1.00 26.72  ? 332  TRP A CD2 1 
ATOM   459  N  NE1 . TRP A 1 69  ? -10.709 -60.205 -11.203 1.00 29.91  ? 332  TRP A NE1 1 
ATOM   460  C  CE2 . TRP A 1 69  ? -11.734 -61.099 -11.341 1.00 28.80  ? 332  TRP A CE2 1 
ATOM   461  C  CE3 . TRP A 1 69  ? -13.635 -61.859 -10.082 1.00 29.01  ? 332  TRP A CE3 1 
ATOM   462  C  CZ2 . TRP A 1 69  ? -12.026 -61.963 -12.392 1.00 31.22  ? 332  TRP A CZ2 1 
ATOM   463  C  CZ3 . TRP A 1 69  ? -13.937 -62.701 -11.126 1.00 27.99  ? 332  TRP A CZ3 1 
ATOM   464  C  CH2 . TRP A 1 69  ? -13.135 -62.758 -12.264 1.00 28.97  ? 332  TRP A CH2 1 
ATOM   465  N  N   . ASP A 1 70  ? -12.276 -60.740 -4.504  1.00 27.11  ? 333  ASP A N   1 
ATOM   466  C  CA  . ASP A 1 70  ? -12.308 -60.280 -3.094  1.00 27.43  ? 333  ASP A CA  1 
ATOM   467  C  C   . ASP A 1 70  ? -10.883 -60.211 -2.527  1.00 28.24  ? 333  ASP A C   1 
ATOM   468  O  O   . ASP A 1 70  ? -10.717 -59.596 -1.432  1.00 32.03  ? 333  ASP A O   1 
ATOM   469  C  CB  . ASP A 1 70  ? -13.203 -61.190 -2.266  1.00 29.67  ? 333  ASP A CB  1 
ATOM   470  C  CG  . ASP A 1 70  ? -14.678 -61.034 -2.610  1.00 30.97  ? 333  ASP A CG  1 
ATOM   471  O  OD1 . ASP A 1 70  ? -15.025 -60.116 -3.426  1.00 30.99  ? 333  ASP A OD1 1 
ATOM   472  O  OD2 . ASP A 1 70  ? -15.466 -61.808 -2.044  1.00 30.43  ? 333  ASP A OD2 1 
ATOM   473  N  N   . ILE A 1 71  ? -9.909  -60.867 -3.169  1.00 28.59  ? 334  ILE A N   1 
ATOM   474  C  CA  . ILE A 1 71  ? -8.514  -60.988 -2.645  1.00 27.42  ? 334  ILE A CA  1 
ATOM   475  C  C   . ILE A 1 71  ? -7.526  -60.226 -3.553  1.00 31.88  ? 334  ILE A C   1 
ATOM   476  O  O   . ILE A 1 71  ? -6.309  -60.353 -3.308  1.00 37.30  ? 334  ILE A O   1 
ATOM   477  C  CB  . ILE A 1 71  ? -8.135  -62.474 -2.434  1.00 29.91  ? 334  ILE A CB  1 
ATOM   478  C  CG1 . ILE A 1 71  ? -8.179  -63.320 -3.710  1.00 30.59  ? 334  ILE A CG1 1 
ATOM   479  C  CG2 . ILE A 1 71  ? -8.979  -63.116 -1.367  1.00 29.36  ? 334  ILE A CG2 1 
ATOM   480  C  CD1 . ILE A 1 71  ? -7.502  -64.643 -3.568  1.00 35.10  ? 334  ILE A CD1 1 
ATOM   481  N  N   . ILE A 1 72  ? -7.995  -59.467 -4.556  1.00 30.65  ? 335  ILE A N   1 
ATOM   482  C  CA  . ILE A 1 72  ? -7.174  -58.652 -5.484  1.00 29.75  ? 335  ILE A CA  1 
ATOM   483  C  C   . ILE A 1 72  ? -7.170  -57.211 -4.994  1.00 36.14  ? 335  ILE A C   1 
ATOM   484  O  O   . ILE A 1 72  ? -8.164  -56.489 -5.184  1.00 33.37  ? 335  ILE A O   1 
ATOM   485  C  CB  . ILE A 1 72  ? -7.732  -58.720 -6.915  1.00 35.87  ? 335  ILE A CB  1 
ATOM   486  C  CG1 . ILE A 1 72  ? -7.913  -60.153 -7.428  1.00 34.99  ? 335  ILE A CG1 1 
ATOM   487  C  CG2 . ILE A 1 72  ? -6.882  -57.862 -7.855  1.00 32.90  ? 335  ILE A CG2 1 
ATOM   488  C  CD1 . ILE A 1 72  ? -6.639  -60.886 -7.654  1.00 37.17  ? 335  ILE A CD1 1 
ATOM   489  N  N   . PRO A 1 73  ? -6.067  -56.735 -4.354  1.00 38.78  ? 336  PRO A N   1 
ATOM   490  C  CA  . PRO A 1 73  ? -6.000  -55.379 -3.796  1.00 35.86  ? 336  PRO A CA  1 
ATOM   491  C  C   . PRO A 1 73  ? -6.326  -54.258 -4.791  1.00 37.41  ? 336  PRO A C   1 
ATOM   492  O  O   . PRO A 1 73  ? -6.977  -53.325 -4.424  1.00 38.40  ? 336  PRO A O   1 
ATOM   493  C  CB  . PRO A 1 73  ? -4.542  -55.228 -3.369  1.00 42.21  ? 336  PRO A CB  1 
ATOM   494  C  CG  . PRO A 1 73  ? -4.127  -56.654 -3.057  1.00 43.83  ? 336  PRO A CG  1 
ATOM   495  C  CD  . PRO A 1 73  ? -4.832  -57.494 -4.109  1.00 42.93  ? 336  PRO A CD  1 
ATOM   496  N  N   . MET A 1 74  ? -5.947  -54.405 -6.054  1.00 39.19  ? 337  MET A N   1 
ATOM   497  C  CA  . MET A 1 74  ? -6.308  -53.403 -7.090  1.00 42.17  ? 337  MET A CA  1 
ATOM   498  C  C   . MET A 1 74  ? -7.843  -53.243 -7.156  1.00 39.49  ? 337  MET A C   1 
ATOM   499  O  O   . MET A 1 74  ? -8.280  -52.102 -7.305  1.00 43.27  ? 337  MET A O   1 
ATOM   500  C  CB  . MET A 1 74  ? -5.716  -53.790 -8.448  1.00 47.01  ? 337  MET A CB  1 
ATOM   501  C  CG  . MET A 1 74  ? -4.172  -53.723 -8.466  1.00 55.92  ? 337  MET A CG  1 
ATOM   502  S  SD  . MET A 1 74  ? -3.492  -52.022 -8.219  1.00 69.31  ? 337  MET A SD  1 
ATOM   503  C  CE  . MET A 1 74  ? -4.604  -51.058 -9.251  1.00 65.67  ? 337  MET A CE  1 
ATOM   504  N  N   . VAL A 1 75  ? -8.628  -54.323 -7.017  1.00 31.94  ? 338  VAL A N   1 
ATOM   505  C  CA  . VAL A 1 75  ? -10.123 -54.270 -7.041  1.00 30.80  ? 338  VAL A CA  1 
ATOM   506  C  C   . VAL A 1 75  ? -10.601 -53.681 -5.714  1.00 30.19  ? 338  VAL A C   1 
ATOM   507  O  O   . VAL A 1 75  ? -11.346 -52.724 -5.758  1.00 34.70  ? 338  VAL A O   1 
ATOM   508  C  CB  . VAL A 1 75  ? -10.776 -55.635 -7.355  1.00 29.80  ? 338  VAL A CB  1 
ATOM   509  C  CG1 . VAL A 1 75  ? -12.281 -55.658 -7.023  1.00 31.48  ? 338  VAL A CG1 1 
ATOM   510  C  CG2 . VAL A 1 75  ? -10.581 -55.993 -8.822  1.00 29.53  ? 338  VAL A CG2 1 
ATOM   511  N  N   . THR A 1 76  ? -10.179 -54.234 -4.584  1.00 33.69  ? 339  THR A N   1 
ATOM   512  C  CA  . THR A 1 76  ? -10.787 -53.984 -3.255  1.00 35.71  ? 339  THR A CA  1 
ATOM   513  C  C   . THR A 1 76  ? -10.418 -52.593 -2.765  1.00 36.57  ? 339  THR A C   1 
ATOM   514  O  O   . THR A 1 76  ? -11.291 -51.961 -2.139  1.00 39.33  ? 339  THR A O   1 
ATOM   515  C  CB  . THR A 1 76  ? -10.373 -55.029 -2.216  1.00 38.21  ? 339  THR A CB  1 
ATOM   516  O  OG1 . THR A 1 76  ? -8.955  -54.993 -2.022  1.00 40.43  ? 339  THR A OG1 1 
ATOM   517  C  CG2 . THR A 1 76  ? -10.793 -56.417 -2.635  1.00 41.41  ? 339  THR A CG2 1 
ATOM   518  N  N   . GLN A 1 77  ? -9.203  -52.128 -3.051  1.00 36.70  ? 340  GLN A N   1 
ATOM   519  C  CA  . GLN A 1 77  ? -8.750  -50.780 -2.618  1.00 44.21  ? 340  GLN A CA  1 
ATOM   520  C  C   . GLN A 1 77  ? -9.561  -49.695 -3.321  1.00 36.82  ? 340  GLN A C   1 
ATOM   521  O  O   . GLN A 1 77  ? -9.605  -48.580 -2.771  1.00 35.94  ? 340  GLN A O   1 
ATOM   522  C  CB  . GLN A 1 77  ? -7.276  -50.496 -2.910  1.00 45.76  ? 340  GLN A CB  1 
ATOM   523  C  CG  . GLN A 1 77  ? -6.320  -51.470 -2.247  1.00 57.27  ? 340  GLN A CG  1 
ATOM   524  C  CD  . GLN A 1 77  ? -6.165  -51.256 -0.766  1.00 65.20  ? 340  GLN A CD  1 
ATOM   525  O  OE1 . GLN A 1 77  ? -6.828  -50.410 -0.168  1.00 74.10  ? 340  GLN A OE1 1 
ATOM   526  N  NE2 . GLN A 1 77  ? -5.269  -52.029 -0.169  1.00 74.43  ? 340  GLN A NE2 1 
ATOM   527  N  N   . MET A 1 78  ? -10.082 -49.955 -4.520  1.00 33.93  ? 341  MET A N   1 
ATOM   528  C  CA  . MET A 1 78  ? -10.834 -48.922 -5.280  1.00 37.44  ? 341  MET A CA  1 
ATOM   529  C  C   . MET A 1 78  ? -12.084 -48.494 -4.503  1.00 39.93  ? 341  MET A C   1 
ATOM   530  O  O   . MET A 1 78  ? -12.523 -47.349 -4.737  1.00 37.70  ? 341  MET A O   1 
ATOM   531  C  CB  . MET A 1 78  ? -11.294 -49.383 -6.662  1.00 39.02  ? 341  MET A CB  1 
ATOM   532  C  CG  . MET A 1 78  ? -10.181 -49.553 -7.670  1.00 45.25  ? 341  MET A CG  1 
ATOM   533  S  SD  . MET A 1 78  ? -10.839 -49.832 -9.353  1.00 49.10  ? 341  MET A SD  1 
ATOM   534  C  CE  . MET A 1 78  ? -12.129 -48.587 -9.332  1.00 43.38  ? 341  MET A CE  1 
ATOM   535  N  N   . ALA A 1 79  ? -12.647 -49.345 -3.627  1.00 38.76  ? 342  ALA A N   1 
ATOM   536  C  CA  . ALA A 1 79  ? -13.904 -49.019 -2.905  1.00 40.62  ? 342  ALA A CA  1 
ATOM   537  C  C   . ALA A 1 79  ? -13.633 -48.314 -1.565  1.00 41.90  ? 342  ALA A C   1 
ATOM   538  O  O   . ALA A 1 79  ? -14.614 -47.957 -0.901  1.00 40.92  ? 342  ALA A O   1 
ATOM   539  C  CB  . ALA A 1 79  ? -14.720 -50.276 -2.698  1.00 44.05  ? 342  ALA A CB  1 
ATOM   540  N  N   . MET A 1 80  ? -12.378 -48.108 -1.160  1.00 44.64  ? 343  MET A N   1 
ATOM   541  C  CA  . MET A 1 80  ? -12.063 -47.455 0.145   1.00 54.34  ? 343  MET A CA  1 
ATOM   542  C  C   . MET A 1 80  ? -11.892 -45.948 -0.075  1.00 60.94  ? 343  MET A C   1 
ATOM   543  O  O   . MET A 1 80  ? -11.866 -45.539 -1.247  1.00 68.07  ? 343  MET A O   1 
ATOM   544  C  CB  . MET A 1 80  ? -10.781 -48.031 0.757   1.00 47.89  ? 343  MET A CB  1 
ATOM   545  C  CG  . MET A 1 80  ? -10.763 -49.554 0.804   1.00 55.73  ? 343  MET A CG  1 
ATOM   546  S  SD  . MET A 1 80  ? -12.116 -50.343 1.781   1.00 53.28  ? 343  MET A SD  1 
ATOM   547  C  CE  . MET A 1 80  ? -11.575 -49.936 3.446   1.00 47.93  ? 343  MET A CE  1 
ATOM   548  N  N   . THR A 1 81  ? -11.754 -45.173 1.010   1.00 81.17  ? 344  THR A N   1 
ATOM   549  C  CA  . THR A 1 81  ? -11.369 -43.739 0.997   1.00 79.06  ? 344  THR A CA  1 
ATOM   550  C  C   . THR A 1 81  ? -12.305 -42.882 1.832   1.00 71.84  ? 344  THR A C   1 
ATOM   551  O  O   . THR A 1 81  ? -13.534 -43.060 1.664   1.00 71.15  ? 344  THR A O   1 
ATOM   552  N  N   . GLU A 1 94  ? -5.733  -29.252 -4.333  0.34 97.84  ? 357  GLU A N   1 
ATOM   553  C  CA  . GLU A 1 94  ? -4.834  -28.161 -3.866  0.34 98.50  ? 357  GLU A CA  1 
ATOM   554  C  C   . GLU A 1 94  ? -4.109  -27.547 -5.070  0.34 99.96  ? 357  GLU A C   1 
ATOM   555  O  O   . GLU A 1 94  ? -3.424  -26.521 -4.885  0.34 99.94  ? 357  GLU A O   1 
ATOM   556  C  CB  . GLU A 1 94  ? -3.843  -28.696 -2.829  0.34 96.97  ? 357  GLU A CB  1 
ATOM   557  C  CG  . GLU A 1 94  ? -4.333  -28.581 -1.393  0.34 95.68  ? 357  GLU A CG  1 
ATOM   558  C  CD  . GLU A 1 94  ? -5.595  -29.362 -1.061  0.34 95.24  ? 357  GLU A CD  1 
ATOM   559  O  OE1 . GLU A 1 94  ? -6.116  -29.191 0.060   0.34 91.51  ? 357  GLU A OE1 1 
ATOM   560  O  OE2 . GLU A 1 94  ? -6.054  -30.143 -1.920  0.34 93.56  ? 357  GLU A OE2 1 
ATOM   561  N  N   . LYS A 1 95  ? -4.267  -28.152 -6.254  0.34 101.04 ? 358  LYS A N   1 
ATOM   562  C  CA  . LYS A 1 95  ? -3.663  -27.685 -7.533  0.34 100.19 ? 358  LYS A CA  1 
ATOM   563  C  C   . LYS A 1 95  ? -4.488  -26.518 -8.092  0.34 99.22  ? 358  LYS A C   1 
ATOM   564  O  O   . LYS A 1 95  ? -3.987  -25.821 -8.998  0.34 95.59  ? 358  LYS A O   1 
ATOM   565  C  CB  . LYS A 1 95  ? -3.590  -28.831 -8.547  0.34 100.13 ? 358  LYS A CB  1 
ATOM   566  C  CG  . LYS A 1 95  ? -3.091  -28.434 -9.931  0.34 98.39  ? 358  LYS A CG  1 
ATOM   567  C  CD  . LYS A 1 95  ? -2.587  -29.598 -10.757 0.34 96.25  ? 358  LYS A CD  1 
ATOM   568  C  CE  . LYS A 1 95  ? -1.710  -29.159 -11.911 0.34 94.87  ? 358  LYS A CE  1 
ATOM   569  N  NZ  . LYS A 1 95  ? -0.960  -30.295 -12.495 0.34 93.31  ? 358  LYS A NZ  1 
ATOM   570  N  N   . VAL A 1 96  ? -5.703  -26.322 -7.568  0.34 99.40  ? 359  VAL A N   1 
ATOM   571  C  CA  . VAL A 1 96  ? -6.645  -25.242 -7.992  0.34 99.30  ? 359  VAL A CA  1 
ATOM   572  C  C   . VAL A 1 96  ? -6.035  -23.883 -7.627  0.34 99.46  ? 359  VAL A C   1 
ATOM   573  O  O   . VAL A 1 96  ? -6.381  -22.884 -8.289  0.34 100.05 ? 359  VAL A O   1 
ATOM   574  C  CB  . VAL A 1 96  ? -8.037  -25.419 -7.355  0.34 97.91  ? 359  VAL A CB  1 
ATOM   575  C  CG1 . VAL A 1 96  ? -8.002  -25.208 -5.849  0.34 97.37  ? 359  VAL A CG1 1 
ATOM   576  C  CG2 . VAL A 1 96  ? -9.069  -24.505 -7.998  0.34 97.49  ? 359  VAL A CG2 1 
ATOM   577  N  N   . ASP A 1 97  ? -5.159  -23.855 -6.617  0.34 97.92  ? 360  ASP A N   1 
ATOM   578  C  CA  . ASP A 1 97  ? -4.515  -22.619 -6.096  0.34 98.02  ? 360  ASP A CA  1 
ATOM   579  C  C   . ASP A 1 97  ? -3.137  -22.454 -6.751  0.34 101.10 ? 360  ASP A C   1 
ATOM   580  O  O   . ASP A 1 97  ? -2.143  -22.313 -6.011  0.34 102.85 ? 360  ASP A O   1 
ATOM   581  C  CB  . ASP A 1 97  ? -4.428  -22.651 -4.568  0.34 96.01  ? 360  ASP A CB  1 
ATOM   582  C  CG  . ASP A 1 97  ? -4.408  -21.277 -3.917  0.34 94.58  ? 360  ASP A CG  1 
ATOM   583  O  OD1 . ASP A 1 97  ? -4.392  -20.273 -4.658  0.34 92.09  ? 360  ASP A OD1 1 
ATOM   584  O  OD2 . ASP A 1 97  ? -4.415  -21.222 -2.672  0.34 94.17  ? 360  ASP A OD2 1 
ATOM   585  N  N   . THR A 1 98  ? -3.090  -22.474 -8.088  0.34 103.38 ? 361  THR A N   1 
ATOM   586  C  CA  . THR A 1 98  ? -1.879  -22.218 -8.918  0.34 104.62 ? 361  THR A CA  1 
ATOM   587  C  C   . THR A 1 98  ? -2.167  -21.035 -9.850  0.34 105.87 ? 361  THR A C   1 
ATOM   588  O  O   . THR A 1 98  ? -3.346  -20.635 -9.926  0.34 104.98 ? 361  THR A O   1 
ATOM   589  C  CB  . THR A 1 98  ? -1.462  -23.476 -9.692  0.34 105.08 ? 361  THR A CB  1 
ATOM   590  O  OG1 . THR A 1 98  ? -2.559  -23.891 -10.506 0.34 104.87 ? 361  THR A OG1 1 
ATOM   591  C  CG2 . THR A 1 98  ? -1.047  -24.614 -8.785  0.34 105.81 ? 361  THR A CG2 1 
ATOM   592  N  N   . ARG A 1 99  ? -1.141  -20.500 -10.525 1.00 108.93 ? 362  ARG A N   1 
ATOM   593  C  CA  . ARG A 1 99  ? -1.294  -19.311 -11.423 1.00 111.22 ? 362  ARG A CA  1 
ATOM   594  C  C   . ARG A 1 99  ? -0.479  -19.484 -12.716 1.00 111.90 ? 362  ARG A C   1 
ATOM   595  O  O   . ARG A 1 99  ? 0.770   -19.471 -12.631 1.00 121.22 ? 362  ARG A O   1 
ATOM   596  C  CB  . ARG A 1 99  ? -0.843  -18.047 -10.679 1.00 118.17 ? 362  ARG A CB  1 
ATOM   597  C  CG  . ARG A 1 99  ? -1.458  -16.753 -11.200 1.00 123.37 ? 362  ARG A CG  1 
ATOM   598  C  CD  . ARG A 1 99  ? -0.500  -15.571 -11.169 1.00 125.74 ? 362  ARG A CD  1 
ATOM   599  N  NE  . ARG A 1 99  ? 0.535   -15.675 -12.198 1.00 129.21 ? 362  ARG A NE  1 
ATOM   600  C  CZ  . ARG A 1 99  ? 1.274   -14.668 -12.666 1.00 113.81 ? 362  ARG A CZ  1 
ATOM   601  N  NH1 . ARG A 1 99  ? 1.114   -13.439 -12.205 1.00 111.73 ? 362  ARG A NH1 1 
ATOM   602  N  NH2 . ARG A 1 99  ? 2.176   -14.897 -13.606 1.00 107.88 ? 362  ARG A NH2 1 
ATOM   603  N  N   . THR A 1 100 ? -1.155  -19.587 -13.870 1.00 104.97 ? 363  THR A N   1 
ATOM   604  C  CA  . THR A 1 100 ? -0.530  -19.702 -15.220 1.00 105.82 ? 363  THR A CA  1 
ATOM   605  C  C   . THR A 1 100 ? -0.197  -18.309 -15.768 1.00 101.17 ? 363  THR A C   1 
ATOM   606  O  O   . THR A 1 100 ? -1.135  -17.522 -15.947 1.00 107.79 ? 363  THR A O   1 
ATOM   607  C  CB  . THR A 1 100 ? -1.434  -20.437 -16.221 1.00 111.97 ? 363  THR A CB  1 
ATOM   608  O  OG1 . THR A 1 100 ? -1.792  -21.712 -15.686 1.00 112.44 ? 363  THR A OG1 1 
ATOM   609  C  CG2 . THR A 1 100 ? -0.775  -20.630 -17.572 1.00 108.32 ? 363  THR A CG2 1 
ATOM   610  N  N   . GLN A 1 101 ? 1.084   -18.045 -16.054 1.00 104.02 ? 364  GLN A N   1 
ATOM   611  C  CA  . GLN A 1 101 ? 1.599   -16.791 -16.678 1.00 97.53  ? 364  GLN A CA  1 
ATOM   612  C  C   . GLN A 1 101 ? 0.866   -16.517 -18.000 1.00 89.81  ? 364  GLN A C   1 
ATOM   613  O  O   . GLN A 1 101 ? 0.387   -17.483 -18.614 1.00 95.11  ? 364  GLN A O   1 
ATOM   614  C  CB  . GLN A 1 101 ? 3.104   -16.918 -16.925 1.00 95.82  ? 364  GLN A CB  1 
ATOM   615  C  CG  . GLN A 1 101 ? 3.688   -15.768 -17.736 1.00 104.59 ? 364  GLN A CG  1 
ATOM   616  C  CD  . GLN A 1 101 ? 5.197   -15.773 -17.748 1.00 109.27 ? 364  GLN A CD  1 
ATOM   617  O  OE1 . GLN A 1 101 ? 5.830   -16.827 -17.689 1.00 104.39 ? 364  GLN A OE1 1 
ATOM   618  N  NE2 . GLN A 1 101 ? 5.783   -14.588 -17.834 1.00 106.54 ? 364  GLN A NE2 1 
ATOM   619  N  N   . GLU A 1 102 ? 0.801   -15.254 -18.437 1.00 82.58  ? 365  GLU A N   1 
ATOM   620  C  CA  . GLU A 1 102 ? 0.143   -14.881 -19.718 1.00 81.77  ? 365  GLU A CA  1 
ATOM   621  C  C   . GLU A 1 102 ? 1.064   -15.242 -20.888 1.00 70.07  ? 365  GLU A C   1 
ATOM   622  O  O   . GLU A 1 102 ? 2.257   -14.935 -20.903 1.00 64.75  ? 365  GLU A O   1 
ATOM   623  C  CB  . GLU A 1 102 ? -0.283  -13.407 -19.741 1.00 90.79  ? 365  GLU A CB  1 
ATOM   624  C  CG  . GLU A 1 102 ? -1.259  -13.089 -20.878 1.00 99.13  ? 365  GLU A CG  1 
ATOM   625  C  CD  . GLU A 1 102 ? -2.055  -11.789 -20.817 1.00 104.31 ? 365  GLU A CD  1 
ATOM   626  O  OE1 . GLU A 1 102 ? -1.476  -10.749 -20.435 1.00 115.24 ? 365  GLU A OE1 1 
ATOM   627  O  OE2 . GLU A 1 102 ? -3.256  -11.810 -21.195 1.00 100.29 ? 365  GLU A OE2 1 
ATOM   628  N  N   . PRO A 1 103 ? 0.536   -15.891 -21.944 1.00 61.29  ? 366  PRO A N   1 
ATOM   629  C  CA  . PRO A 1 103 ? 1.351   -16.251 -23.102 1.00 61.78  ? 366  PRO A CA  1 
ATOM   630  C  C   . PRO A 1 103 ? 2.029   -15.021 -23.714 1.00 55.38  ? 366  PRO A C   1 
ATOM   631  O  O   . PRO A 1 103 ? 1.505   -13.967 -23.544 1.00 50.85  ? 366  PRO A O   1 
ATOM   632  C  CB  . PRO A 1 103 ? 0.339   -16.836 -24.101 1.00 58.48  ? 366  PRO A CB  1 
ATOM   633  C  CG  . PRO A 1 103 ? -0.807  -17.295 -23.242 1.00 59.21  ? 366  PRO A CG  1 
ATOM   634  C  CD  . PRO A 1 103 ? -0.868  -16.289 -22.112 1.00 61.21  ? 366  PRO A CD  1 
ATOM   635  N  N   . LYS A 1 104 ? 3.143   -15.224 -24.417 1.00 60.87  ? 367  LYS A N   1 
ATOM   636  C  CA  . LYS A 1 104 ? 3.825   -14.207 -25.261 1.00 63.88  ? 367  LYS A CA  1 
ATOM   637  C  C   . LYS A 1 104 ? 2.887   -13.769 -26.395 1.00 63.27  ? 367  LYS A C   1 
ATOM   638  O  O   . LYS A 1 104 ? 1.984   -14.544 -26.779 1.00 58.80  ? 367  LYS A O   1 
ATOM   639  C  CB  . LYS A 1 104 ? 5.118   -14.750 -25.896 1.00 72.71  ? 367  LYS A CB  1 
ATOM   640  C  CG  . LYS A 1 104 ? 6.109   -15.490 -24.994 1.00 69.47  ? 367  LYS A CG  1 
ATOM   641  C  CD  . LYS A 1 104 ? 6.191   -14.942 -23.609 1.00 71.83  ? 367  LYS A CD  1 
ATOM   642  C  CE  . LYS A 1 104 ? 7.370   -15.477 -22.835 1.00 76.55  ? 367  LYS A CE  1 
ATOM   643  N  NZ  . LYS A 1 104 ? 7.351   -14.936 -21.456 1.00 77.24  ? 367  LYS A NZ  1 
ATOM   644  N  N   . GLU A 1 105 ? 3.162   -12.597 -26.966 1.00 63.61  ? 368  GLU A N   1 
ATOM   645  C  CA  . GLU A 1 105 ? 2.297   -11.905 -27.956 1.00 66.41  ? 368  GLU A CA  1 
ATOM   646  C  C   . GLU A 1 105 ? 2.139   -12.788 -29.195 1.00 59.26  ? 368  GLU A C   1 
ATOM   647  O  O   . GLU A 1 105 ? 1.023   -12.827 -29.740 1.00 60.62  ? 368  GLU A O   1 
ATOM   648  C  CB  . GLU A 1 105 ? 2.878   -10.533 -28.327 1.00 73.55  ? 368  GLU A CB  1 
ATOM   649  C  CG  . GLU A 1 105 ? 2.938   -9.545  -27.170 1.00 74.18  ? 368  GLU A CG  1 
ATOM   650  C  CD  . GLU A 1 105 ? 1.634   -9.365  -26.407 1.00 80.60  ? 368  GLU A CD  1 
ATOM   651  O  OE1 . GLU A 1 105 ? 0.611   -9.060  -27.049 1.00 83.94  ? 368  GLU A OE1 1 
ATOM   652  O  OE2 . GLU A 1 105 ? 1.638   -9.549  -25.174 1.00 83.70  ? 368  GLU A OE2 1 
ATOM   653  N  N   . GLY A 1 106 ? 3.214   -13.453 -29.629 1.00 52.63  ? 369  GLY A N   1 
ATOM   654  C  CA  . GLY A 1 106 ? 3.196   -14.333 -30.817 1.00 53.29  ? 369  GLY A CA  1 
ATOM   655  C  C   . GLY A 1 106 ? 2.329   -15.568 -30.564 1.00 55.02  ? 369  GLY A C   1 
ATOM   656  O  O   . GLY A 1 106 ? 1.626   -16.001 -31.502 1.00 53.57  ? 369  GLY A O   1 
ATOM   657  N  N   . THR A 1 107 ? 2.352   -16.104 -29.338 1.00 48.22  ? 370  THR A N   1 
ATOM   658  C  CA  . THR A 1 107 ? 1.450   -17.195 -28.897 1.00 52.65  ? 370  THR A CA  1 
ATOM   659  C  C   . THR A 1 107 ? -0.007  -16.709 -28.971 1.00 53.43  ? 370  THR A C   1 
ATOM   660  O  O   . THR A 1 107 ? -0.835  -17.375 -29.626 1.00 55.14  ? 370  THR A O   1 
ATOM   661  C  CB  . THR A 1 107 ? 1.847   -17.707 -27.513 1.00 52.98  ? 370  THR A CB  1 
ATOM   662  O  OG1 . THR A 1 107 ? 3.270   -17.865 -27.518 1.00 47.66  ? 370  THR A OG1 1 
ATOM   663  C  CG2 . THR A 1 107 ? 1.154   -19.009 -27.178 1.00 51.56  ? 370  THR A CG2 1 
ATOM   664  N  N   . LYS A 1 108 ? -0.299  -15.575 -28.323 0.34 52.57  ? 371  LYS A N   1 
ATOM   665  C  CA  . LYS A 1 108 ? -1.653  -14.958 -28.246 0.34 51.54  ? 371  LYS A CA  1 
ATOM   666  C  C   . LYS A 1 108 ? -2.209  -14.722 -29.659 0.34 48.58  ? 371  LYS A C   1 
ATOM   667  O  O   . LYS A 1 108 ? -3.411  -14.968 -29.863 0.34 46.28  ? 371  LYS A O   1 
ATOM   668  C  CB  . LYS A 1 108 ? -1.599  -13.657 -27.439 0.34 52.64  ? 371  LYS A CB  1 
ATOM   669  C  CG  . LYS A 1 108 ? -1.311  -13.840 -25.954 0.34 53.88  ? 371  LYS A CG  1 
ATOM   670  C  CD  . LYS A 1 108 ? -1.808  -12.701 -25.090 0.34 55.02  ? 371  LYS A CD  1 
ATOM   671  C  CE  . LYS A 1 108 ? -1.054  -11.408 -25.310 0.34 57.25  ? 371  LYS A CE  1 
ATOM   672  N  NZ  . LYS A 1 108 ? -1.467  -10.363 -24.342 0.34 59.17  ? 371  LYS A NZ  1 
ATOM   673  N  N   . LYS A 1 109 ? -1.367  -14.281 -30.596 0.34 46.50  ? 372  LYS A N   1 
ATOM   674  C  CA  . LYS A 1 109 ? -1.747  -14.076 -32.019 0.34 46.99  ? 372  LYS A CA  1 
ATOM   675  C  C   . LYS A 1 109 ? -2.159  -15.423 -32.627 0.34 47.28  ? 372  LYS A C   1 
ATOM   676  O  O   . LYS A 1 109 ? -3.299  -15.514 -33.135 0.34 47.39  ? 372  LYS A O   1 
ATOM   677  C  CB  . LYS A 1 109 ? -0.592  -13.443 -32.801 0.34 48.18  ? 372  LYS A CB  1 
ATOM   678  C  CG  . LYS A 1 109 ? -0.838  -13.251 -34.294 0.34 49.16  ? 372  LYS A CG  1 
ATOM   679  C  CD  . LYS A 1 109 ? -2.002  -12.326 -34.630 0.34 49.94  ? 372  LYS A CD  1 
ATOM   680  C  CE  . LYS A 1 109 ? -1.737  -10.872 -34.301 0.34 49.55  ? 372  LYS A CE  1 
ATOM   681  N  NZ  . LYS A 1 109 ? -2.700  -9.971  -34.977 0.34 48.62  ? 372  LYS A NZ  1 
ATOM   682  N  N   . LEU A 1 110 ? -1.262  -16.417 -32.572 0.34 46.73  ? 373  LEU A N   1 
ATOM   683  C  CA  . LEU A 1 110 ? -1.469  -17.794 -33.103 0.34 45.57  ? 373  LEU A CA  1 
ATOM   684  C  C   . LEU A 1 110 ? -2.802  -18.352 -32.589 0.34 42.76  ? 373  LEU A C   1 
ATOM   685  O  O   . LEU A 1 110 ? -3.547  -18.923 -33.405 0.34 41.32  ? 373  LEU A O   1 
ATOM   686  C  CB  . LEU A 1 110 ? -0.303  -18.689 -32.669 0.34 46.17  ? 373  LEU A CB  1 
ATOM   687  C  CG  . LEU A 1 110 ? 1.002   -18.494 -33.440 0.34 47.27  ? 373  LEU A CG  1 
ATOM   688  C  CD1 . LEU A 1 110 ? 2.161   -19.181 -32.730 0.34 45.97  ? 373  LEU A CD1 1 
ATOM   689  C  CD2 . LEU A 1 110 ? 0.865   -19.001 -34.870 0.34 47.42  ? 373  LEU A CD2 1 
ATOM   690  N  N   . MET A 1 111 ? -3.076  -18.190 -31.291 1.00 40.32  ? 374  MET A N   1 
ATOM   691  C  CA  . MET A 1 111 ? -4.329  -18.668 -30.645 1.00 42.12  ? 374  MET A CA  1 
ATOM   692  C  C   . MET A 1 111 ? -5.571  -17.929 -31.200 1.00 47.35  ? 374  MET A C   1 
ATOM   693  O  O   . MET A 1 111 ? -6.584  -18.600 -31.495 1.00 43.88  ? 374  MET A O   1 
ATOM   694  C  CB  . MET A 1 111 ? -4.253  -18.512 -29.114 1.00 40.71  ? 374  MET A CB  1 
ATOM   695  C  CG  . MET A 1 111 ? -3.250  -19.467 -28.442 1.00 41.41  ? 374  MET A CG  1 
ATOM   696  S  SD  . MET A 1 111 ? -3.409  -19.696 -26.641 1.00 46.60  ? 374  MET A SD  1 
ATOM   697  C  CE  . MET A 1 111 ? -3.040  -18.041 -26.067 1.00 50.16  ? 374  MET A CE  1 
ATOM   698  N  N   . LYS A 1 112 ? -5.480  -16.602 -31.355 0.34 45.48  ? 375  LYS A N   1 
ATOM   699  C  CA  . LYS A 1 112 ? -6.594  -15.729 -31.815 0.34 46.32  ? 375  LYS A CA  1 
ATOM   700  C  C   . LYS A 1 112 ? -6.969  -16.097 -33.257 0.34 45.57  ? 375  LYS A C   1 
ATOM   701  O  O   . LYS A 1 112 ? -8.173  -16.248 -33.527 0.34 45.26  ? 375  LYS A O   1 
ATOM   702  C  CB  . LYS A 1 112 ? -6.197  -14.251 -31.717 0.34 48.63  ? 375  LYS A CB  1 
ATOM   703  C  CG  . LYS A 1 112 ? -7.189  -13.354 -30.985 0.34 50.14  ? 375  LYS A CG  1 
ATOM   704  C  CD  . LYS A 1 112 ? -6.975  -13.334 -29.480 0.34 50.84  ? 375  LYS A CD  1 
ATOM   705  C  CE  . LYS A 1 112 ? -8.190  -12.884 -28.695 0.34 50.89  ? 375  LYS A CE  1 
ATOM   706  N  NZ  . LYS A 1 112 ? -8.042  -13.163 -27.247 0.34 49.35  ? 375  LYS A NZ  1 
ATOM   707  N  N   . ILE A 1 113 ? -5.976  -16.246 -34.140 0.34 44.32  ? 376  ILE A N   1 
ATOM   708  C  CA  . ILE A 1 113 ? -6.176  -16.571 -35.585 0.34 44.73  ? 376  ILE A CA  1 
ATOM   709  C  C   . ILE A 1 113 ? -6.750  -17.986 -35.719 0.34 44.67  ? 376  ILE A C   1 
ATOM   710  O  O   . ILE A 1 113 ? -7.653  -18.170 -36.557 0.34 44.65  ? 376  ILE A O   1 
ATOM   711  C  CB  . ILE A 1 113 ? -4.867  -16.431 -36.385 0.34 44.94  ? 376  ILE A CB  1 
ATOM   712  C  CG1 . ILE A 1 113 ? -4.520  -14.966 -36.662 0.34 47.14  ? 376  ILE A CG1 1 
ATOM   713  C  CG2 . ILE A 1 113 ? -4.942  -17.232 -37.674 0.34 44.57  ? 376  ILE A CG2 1 
ATOM   714  C  CD1 . ILE A 1 113 ? -3.193  -14.777 -37.364 0.34 47.87  ? 376  ILE A CD1 1 
ATOM   715  N  N   . THR A 1 114 ? -6.221  -18.949 -34.952 1.00 46.39  ? 377  THR A N   1 
ATOM   716  C  CA  . THR A 1 114 ? -6.648  -20.378 -35.022 1.00 41.14  ? 377  THR A CA  1 
ATOM   717  C  C   . THR A 1 114 ? -8.091  -20.515 -34.522 1.00 36.59  ? 377  THR A C   1 
ATOM   718  O  O   . THR A 1 114 ? -8.868  -21.209 -35.190 1.00 35.55  ? 377  THR A O   1 
ATOM   719  C  CB  . THR A 1 114 ? -5.707  -21.307 -34.249 1.00 36.59  ? 377  THR A CB  1 
ATOM   720  O  OG1 . THR A 1 114 ? -4.367  -21.057 -34.653 1.00 37.33  ? 377  THR A OG1 1 
ATOM   721  C  CG2 . THR A 1 114 ? -5.982  -22.758 -34.531 1.00 35.64  ? 377  THR A CG2 1 
ATOM   722  N  N   . ALA A 1 115 ? -8.410  -19.865 -33.399 1.00 38.32  ? 378  ALA A N   1 
ATOM   723  C  CA  . ALA A 1 115 ? -9.739  -19.862 -32.746 1.00 38.55  ? 378  ALA A CA  1 
ATOM   724  C  C   . ALA A 1 115 ? -10.794 -19.276 -33.699 1.00 41.37  ? 378  ALA A C   1 
ATOM   725  O  O   . ALA A 1 115 ? -11.889 -19.915 -33.905 1.00 40.19  ? 378  ALA A O   1 
ATOM   726  C  CB  . ALA A 1 115 ? -9.679  -19.097 -31.456 1.00 36.19  ? 378  ALA A CB  1 
ATOM   727  N  N   . GLU A 1 116 ? -10.502 -18.110 -34.287 0.34 39.40  ? 379  GLU A N   1 
ATOM   728  C  CA  . GLU A 1 116 ? -11.410 -17.435 -35.255 0.34 38.89  ? 379  GLU A CA  1 
ATOM   729  C  C   . GLU A 1 116 ? -11.682 -18.391 -36.424 0.34 38.71  ? 379  GLU A C   1 
ATOM   730  O  O   . GLU A 1 116 ? -12.866 -18.584 -36.763 0.34 38.72  ? 379  GLU A O   1 
ATOM   731  C  CB  . GLU A 1 116 ? -10.837 -16.103 -35.745 0.34 37.68  ? 379  GLU A CB  1 
ATOM   732  C  CG  . GLU A 1 116 ? -11.637 -15.510 -36.897 0.34 37.83  ? 379  GLU A CG  1 
ATOM   733  C  CD  . GLU A 1 116 ? -11.474 -14.018 -37.143 0.34 37.01  ? 379  GLU A CD  1 
ATOM   734  O  OE1 . GLU A 1 116 ? -10.626 -13.392 -36.472 0.34 35.46  ? 379  GLU A OE1 1 
ATOM   735  O  OE2 . GLU A 1 116 ? -12.208 -13.485 -38.006 0.34 36.93  ? 379  GLU A OE2 1 
ATOM   736  N  N   . TRP A 1 117 ? -10.631 -18.983 -37.000 1.00 38.31  ? 380  TRP A N   1 
ATOM   737  C  CA  . TRP A 1 117 ? -10.774 -19.946 -38.115 1.00 35.34  ? 380  TRP A CA  1 
ATOM   738  C  C   . TRP A 1 117 ? -11.566 -21.194 -37.671 1.00 42.37  ? 380  TRP A C   1 
ATOM   739  O  O   . TRP A 1 117 ? -12.330 -21.764 -38.521 1.00 40.92  ? 380  TRP A O   1 
ATOM   740  C  CB  . TRP A 1 117 ? -9.377  -20.307 -38.615 1.00 37.08  ? 380  TRP A CB  1 
ATOM   741  C  CG  . TRP A 1 117 ? -9.401  -21.391 -39.626 1.00 31.99  ? 380  TRP A CG  1 
ATOM   742  C  CD1 . TRP A 1 117 ? -9.556  -21.246 -40.961 1.00 33.67  ? 380  TRP A CD1 1 
ATOM   743  C  CD2 . TRP A 1 117 ? -9.389  -22.796 -39.365 1.00 38.15  ? 380  TRP A CD2 1 
ATOM   744  N  NE1 . TRP A 1 117 ? -9.562  -22.465 -41.570 1.00 40.04  ? 380  TRP A NE1 1 
ATOM   745  C  CE2 . TRP A 1 117 ? -9.464  -23.442 -40.612 1.00 38.65  ? 380  TRP A CE2 1 
ATOM   746  C  CE3 . TRP A 1 117 ? -9.258  -23.572 -38.212 1.00 38.80  ? 380  TRP A CE3 1 
ATOM   747  C  CZ2 . TRP A 1 117 ? -9.431  -24.831 -40.735 1.00 39.65  ? 380  TRP A CZ2 1 
ATOM   748  C  CZ3 . TRP A 1 117 ? -9.214  -24.941 -38.336 1.00 35.90  ? 380  TRP A CZ3 1 
ATOM   749  C  CH2 . TRP A 1 117 ? -9.331  -25.562 -39.575 1.00 35.59  ? 380  TRP A CH2 1 
ATOM   750  N  N   . LEU A 1 118 ? -11.407 -21.638 -36.414 1.00 39.62  ? 381  LEU A N   1 
ATOM   751  C  CA  . LEU A 1 118 ? -11.999 -22.928 -35.954 1.00 37.31  ? 381  LEU A CA  1 
ATOM   752  C  C   . LEU A 1 118 ? -13.501 -22.750 -35.687 1.00 35.51  ? 381  LEU A C   1 
ATOM   753  O  O   . LEU A 1 118 ? -14.274 -23.623 -36.124 1.00 33.50  ? 381  LEU A O   1 
ATOM   754  C  CB  . LEU A 1 118 ? -11.275 -23.437 -34.705 1.00 37.76  ? 381  LEU A CB  1 
ATOM   755  C  CG  . LEU A 1 118 ? -11.661 -24.859 -34.292 1.00 38.97  ? 381  LEU A CG  1 
ATOM   756  C  CD1 . LEU A 1 118 ? -11.460 -25.854 -35.434 1.00 36.94  ? 381  LEU A CD1 1 
ATOM   757  C  CD2 . LEU A 1 118 ? -10.882 -25.285 -33.061 1.00 41.02  ? 381  LEU A CD2 1 
ATOM   758  N  N   . TRP A 1 119 ? -13.898 -21.663 -35.019 1.00 32.53  ? 382  TRP A N   1 
ATOM   759  C  CA  . TRP A 1 119 ? -15.334 -21.295 -34.857 1.00 40.57  ? 382  TRP A CA  1 
ATOM   760  C  C   . TRP A 1 119 ? -16.022 -21.164 -36.229 1.00 42.93  ? 382  TRP A C   1 
ATOM   761  O  O   . TRP A 1 119 ? -17.141 -21.739 -36.390 1.00 45.55  ? 382  TRP A O   1 
ATOM   762  C  CB  . TRP A 1 119 ? -15.482 -20.034 -34.014 1.00 35.35  ? 382  TRP A CB  1 
ATOM   763  C  CG  . TRP A 1 119 ? -15.315 -20.259 -32.547 1.00 32.66  ? 382  TRP A CG  1 
ATOM   764  C  CD1 . TRP A 1 119 ? -14.549 -19.517 -31.694 1.00 34.60  ? 382  TRP A CD1 1 
ATOM   765  C  CD2 . TRP A 1 119 ? -15.961 -21.258 -31.737 1.00 32.29  ? 382  TRP A CD2 1 
ATOM   766  N  NE1 . TRP A 1 119 ? -14.694 -19.967 -30.409 1.00 32.82  ? 382  TRP A NE1 1 
ATOM   767  C  CE2 . TRP A 1 119 ? -15.571 -21.023 -30.407 1.00 32.81  ? 382  TRP A CE2 1 
ATOM   768  C  CE3 . TRP A 1 119 ? -16.882 -22.277 -31.989 1.00 35.62  ? 382  TRP A CE3 1 
ATOM   769  C  CZ2 . TRP A 1 119 ? -15.998 -21.825 -29.359 1.00 33.32  ? 382  TRP A CZ2 1 
ATOM   770  C  CZ3 . TRP A 1 119 ? -17.342 -23.041 -30.944 1.00 33.10  ? 382  TRP A CZ3 1 
ATOM   771  C  CH2 . TRP A 1 119 ? -16.891 -22.824 -29.649 1.00 31.00  ? 382  TRP A CH2 1 
ATOM   772  N  N   . LYS A 1 120 ? -15.365 -20.541 -37.217 1.00 39.88  ? 383  LYS A N   1 
ATOM   773  C  CA  . LYS A 1 120 ? -15.907 -20.484 -38.599 1.00 42.79  ? 383  LYS A CA  1 
ATOM   774  C  C   . LYS A 1 120 ? -16.153 -21.903 -39.098 1.00 42.45  ? 383  LYS A C   1 
ATOM   775  O  O   . LYS A 1 120 ? -17.268 -22.166 -39.562 1.00 45.81  ? 383  LYS A O   1 
ATOM   776  C  CB  . LYS A 1 120 ? -14.997 -19.751 -39.592 1.00 53.48  ? 383  LYS A CB  1 
ATOM   777  C  CG  . LYS A 1 120 ? -15.221 -18.250 -39.704 1.00 63.88  ? 383  LYS A CG  1 
ATOM   778  C  CD  . LYS A 1 120 ? -14.907 -17.696 -41.083 1.00 75.89  ? 383  LYS A CD  1 
ATOM   779  C  CE  . LYS A 1 120 ? -14.709 -16.194 -41.080 1.00 86.56  ? 383  LYS A CE  1 
ATOM   780  N  NZ  . LYS A 1 120 ? -13.647 -15.783 -40.126 1.00 94.99  ? 383  LYS A NZ  1 
ATOM   781  N  N   . GLU A 1 121 ? -15.161 -22.792 -39.033 1.00 39.64  ? 384  GLU A N   1 
ATOM   782  C  CA  . GLU A 1 121 ? -15.321 -24.154 -39.606 1.00 41.36  ? 384  GLU A CA  1 
ATOM   783  C  C   . GLU A 1 121 ? -16.472 -24.878 -38.916 1.00 38.05  ? 384  GLU A C   1 
ATOM   784  O  O   . GLU A 1 121 ? -17.233 -25.566 -39.624 1.00 42.23  ? 384  GLU A O   1 
ATOM   785  C  CB  . GLU A 1 121 ? -14.093 -25.033 -39.409 1.00 41.09  ? 384  GLU A CB  1 
ATOM   786  C  CG  . GLU A 1 121 ? -12.959 -24.614 -40.276 1.00 43.47  ? 384  GLU A CG  1 
ATOM   787  C  CD  . GLU A 1 121 ? -13.195 -24.774 -41.760 1.00 46.97  ? 384  GLU A CD  1 
ATOM   788  O  OE1 . GLU A 1 121 ? -13.705 -25.850 -42.185 1.00 44.57  ? 384  GLU A OE1 1 
ATOM   789  O  OE2 . GLU A 1 121 ? -12.829 -23.830 -42.480 1.00 48.56  ? 384  GLU A OE2 1 
ATOM   790  N  N   . LEU A 1 122 ? -16.538 -24.788 -37.583 1.00 38.14  ? 385  LEU A N   1 
ATOM   791  C  CA  . LEU A 1 122 ? -17.512 -25.555 -36.766 1.00 36.00  ? 385  LEU A CA  1 
ATOM   792  C  C   . LEU A 1 122 ? -18.905 -25.013 -37.100 1.00 36.67  ? 385  LEU A C   1 
ATOM   793  O  O   . LEU A 1 122 ? -19.862 -25.809 -37.097 1.00 37.47  ? 385  LEU A O   1 
ATOM   794  C  CB  . LEU A 1 122 ? -17.191 -25.416 -35.272 1.00 34.73  ? 385  LEU A CB  1 
ATOM   795  C  CG  . LEU A 1 122 ? -15.923 -26.139 -34.798 1.00 35.53  ? 385  LEU A CG  1 
ATOM   796  C  CD1 . LEU A 1 122 ? -15.661 -25.913 -33.320 1.00 31.00  ? 385  LEU A CD1 1 
ATOM   797  C  CD2 . LEU A 1 122 ? -16.025 -27.628 -35.088 1.00 35.58  ? 385  LEU A CD2 1 
ATOM   798  N  N   . GLY A 1 123 ? -18.962 -23.720 -37.420 1.00 39.66  ? 386  GLY A N   1 
ATOM   799  C  CA  . GLY A 1 123 ? -20.189 -22.970 -37.749 1.00 44.65  ? 386  GLY A CA  1 
ATOM   800  C  C   . GLY A 1 123 ? -20.665 -23.189 -39.176 1.00 45.53  ? 386  GLY A C   1 
ATOM   801  O  O   . GLY A 1 123 ? -21.823 -22.879 -39.423 1.00 48.48  ? 386  GLY A O   1 
ATOM   802  N  N   . LYS A 1 124 ? -19.850 -23.717 -40.092 1.00 42.31  ? 387  LYS A N   1 
ATOM   803  C  CA  . LYS A 1 124 ? -20.244 -23.778 -41.525 1.00 45.37  ? 387  LYS A CA  1 
ATOM   804  C  C   . LYS A 1 124 ? -21.578 -24.498 -41.717 1.00 46.88  ? 387  LYS A C   1 
ATOM   805  O  O   . LYS A 1 124 ? -22.292 -24.119 -42.638 1.00 50.45  ? 387  LYS A O   1 
ATOM   806  C  CB  . LYS A 1 124 ? -19.214 -24.482 -42.400 1.00 44.68  ? 387  LYS A CB  1 
ATOM   807  C  CG  . LYS A 1 124 ? -18.082 -23.569 -42.851 1.00 52.98  ? 387  LYS A CG  1 
ATOM   808  C  CD  . LYS A 1 124 ? -17.167 -24.225 -43.862 1.00 56.25  ? 387  LYS A CD  1 
ATOM   809  C  CE  . LYS A 1 124 ? -15.814 -23.557 -43.993 1.00 58.79  ? 387  LYS A CE  1 
ATOM   810  N  NZ  . LYS A 1 124 ? -14.906 -24.426 -44.788 1.00 67.33  ? 387  LYS A NZ  1 
ATOM   811  N  N   . LYS A 1 125 ? -21.857 -25.541 -40.942 1.00 46.30  ? 388  LYS A N   1 
ATOM   812  C  CA  . LYS A 1 125 ? -23.030 -26.424 -41.157 1.00 45.19  ? 388  LYS A CA  1 
ATOM   813  C  C   . LYS A 1 125 ? -23.872 -26.500 -39.881 1.00 41.26  ? 388  LYS A C   1 
ATOM   814  O  O   . LYS A 1 125 ? -24.601 -27.462 -39.722 1.00 47.95  ? 388  LYS A O   1 
ATOM   815  C  CB  . LYS A 1 125 ? -22.548 -27.813 -41.563 1.00 46.57  ? 388  LYS A CB  1 
ATOM   816  C  CG  . LYS A 1 125 ? -21.743 -27.869 -42.845 1.00 55.17  ? 388  LYS A CG  1 
ATOM   817  C  CD  . LYS A 1 125 ? -21.275 -29.288 -43.171 1.00 65.51  ? 388  LYS A CD  1 
ATOM   818  C  CE  . LYS A 1 125 ? -20.114 -29.749 -42.307 1.00 72.70  ? 388  LYS A CE  1 
ATOM   819  N  NZ  . LYS A 1 125 ? -20.101 -31.225 -42.139 1.00 75.00  ? 388  LYS A NZ  1 
ATOM   820  N  N   . LYS A 1 126 ? -23.731 -25.539 -38.982 1.00 42.03  ? 389  LYS A N   1 
ATOM   821  C  CA  . LYS A 1 126 ? -24.488 -25.497 -37.716 1.00 45.81  ? 389  LYS A CA  1 
ATOM   822  C  C   . LYS A 1 126 ? -24.968 -24.068 -37.497 1.00 46.76  ? 389  LYS A C   1 
ATOM   823  O  O   . LYS A 1 126 ? -24.246 -23.148 -37.872 1.00 44.97  ? 389  LYS A O   1 
ATOM   824  C  CB  . LYS A 1 126 ? -23.634 -25.875 -36.503 1.00 45.55  ? 389  LYS A CB  1 
ATOM   825  C  CG  . LYS A 1 126 ? -23.051 -27.272 -36.520 1.00 45.04  ? 389  LYS A CG  1 
ATOM   826  C  CD  . LYS A 1 126 ? -24.091 -28.326 -36.340 1.00 44.40  ? 389  LYS A CD  1 
ATOM   827  C  CE  . LYS A 1 126 ? -23.451 -29.651 -36.031 1.00 43.41  ? 389  LYS A CE  1 
ATOM   828  N  NZ  . LYS A 1 126 ? -24.333 -30.762 -36.400 1.00 40.65  ? 389  LYS A NZ  1 
ATOM   829  N  N   . THR A 1 127 ? -26.118 -23.921 -36.836 1.00 46.60  ? 390  THR A N   1 
ATOM   830  C  CA  . THR A 1 127 ? -26.734 -22.624 -36.489 1.00 43.95  ? 390  THR A CA  1 
ATOM   831  C  C   . THR A 1 127 ? -26.773 -22.531 -34.981 1.00 36.06  ? 390  THR A C   1 
ATOM   832  O  O   . THR A 1 127 ? -27.549 -23.234 -34.352 1.00 42.56  ? 390  THR A O   1 
ATOM   833  C  CB  . THR A 1 127 ? -28.162 -22.540 -37.043 1.00 51.27  ? 390  THR A CB  1 
ATOM   834  O  OG1 . THR A 1 127 ? -28.032 -22.653 -38.459 1.00 47.16  ? 390  THR A OG1 1 
ATOM   835  C  CG2 . THR A 1 127 ? -28.890 -21.281 -36.617 1.00 50.90  ? 390  THR A CG2 1 
ATOM   836  N  N   . PRO A 1 128 ? -26.000 -21.627 -34.351 1.00 37.28  ? 391  PRO A N   1 
ATOM   837  C  CA  . PRO A 1 128 ? -26.160 -21.405 -32.915 1.00 37.93  ? 391  PRO A CA  1 
ATOM   838  C  C   . PRO A 1 128 ? -27.648 -21.114 -32.641 1.00 43.32  ? 391  PRO A C   1 
ATOM   839  O  O   . PRO A 1 128 ? -28.340 -20.570 -33.500 1.00 42.35  ? 391  PRO A O   1 
ATOM   840  C  CB  . PRO A 1 128 ? -25.278 -20.197 -32.599 1.00 35.11  ? 391  PRO A CB  1 
ATOM   841  C  CG  . PRO A 1 128 ? -24.347 -20.094 -33.787 1.00 37.02  ? 391  PRO A CG  1 
ATOM   842  C  CD  . PRO A 1 128 ? -25.045 -20.715 -34.978 1.00 33.73  ? 391  PRO A CD  1 
ATOM   843  N  N   . ARG A 1 129 ? -28.130 -21.482 -31.467 1.00 46.52  ? 392  ARG A N   1 
ATOM   844  C  CA  . ARG A 1 129 ? -29.559 -21.279 -31.103 1.00 45.48  ? 392  ARG A CA  1 
ATOM   845  C  C   . ARG A 1 129 ? -29.711 -21.479 -29.598 1.00 51.46  ? 392  ARG A C   1 
ATOM   846  O  O   . ARG A 1 129 ? -28.873 -22.213 -29.016 1.00 49.46  ? 392  ARG A O   1 
ATOM   847  C  CB  . ARG A 1 129 ? -30.445 -22.198 -31.948 1.00 44.42  ? 392  ARG A CB  1 
ATOM   848  C  CG  . ARG A 1 129 ? -30.104 -23.676 -31.873 1.00 43.84  ? 392  ARG A CG  1 
ATOM   849  C  CD  . ARG A 1 129 ? -31.024 -24.319 -30.893 1.00 42.19  ? 392  ARG A CD  1 
ATOM   850  N  NE  . ARG A 1 129 ? -30.813 -25.738 -30.709 1.00 41.49  ? 392  ARG A NE  1 
ATOM   851  C  CZ  . ARG A 1 129 ? -31.385 -26.431 -29.736 1.00 42.41  ? 392  ARG A CZ  1 
ATOM   852  N  NH1 . ARG A 1 129 ? -32.224 -25.835 -28.900 1.00 43.19  ? 392  ARG A NH1 1 
ATOM   853  N  NH2 . ARG A 1 129 ? -31.143 -27.718 -29.609 1.00 44.62  ? 392  ARG A NH2 1 
ATOM   854  N  N   . MET A 1 130 ? -30.699 -20.818 -28.981 1.00 50.38  ? 393  MET A N   1 
ATOM   855  C  CA  . MET A 1 130 ? -30.933 -20.925 -27.521 1.00 50.16  ? 393  MET A CA  1 
ATOM   856  C  C   . MET A 1 130 ? -31.559 -22.285 -27.225 1.00 45.58  ? 393  MET A C   1 
ATOM   857  O  O   . MET A 1 130 ? -32.333 -22.765 -28.046 1.00 48.75  ? 393  MET A O   1 
ATOM   858  C  CB  . MET A 1 130 ? -31.856 -19.823 -27.010 1.00 60.16  ? 393  MET A CB  1 
ATOM   859  C  CG  . MET A 1 130 ? -31.383 -18.430 -27.360 1.00 67.87  ? 393  MET A CG  1 
ATOM   860  S  SD  . MET A 1 130 ? -32.154 -17.146 -26.332 1.00 75.03  ? 393  MET A SD  1 
ATOM   861  C  CE  . MET A 1 130 ? -33.795 -17.836 -26.097 1.00 75.52  ? 393  MET A CE  1 
ATOM   862  N  N   . CYS A 1 131 ? -31.197 -22.919 -26.118 1.00 44.18  ? 394  CYS A N   1 
ATOM   863  C  CA  . CYS A 1 131 ? -31.924 -24.116 -25.624 1.00 46.65  ? 394  CYS A CA  1 
ATOM   864  C  C   . CYS A 1 131 ? -33.102 -23.610 -24.760 1.00 51.17  ? 394  CYS A C   1 
ATOM   865  O  O   . CYS A 1 131 ? -33.067 -22.448 -24.277 1.00 54.10  ? 394  CYS A O   1 
ATOM   866  C  CB  . CYS A 1 131 ? -30.962 -25.097 -24.967 1.00 47.23  ? 394  CYS A CB  1 
ATOM   867  S  SG  . CYS A 1 131 ? -29.784 -25.831 -26.139 1.00 47.43  ? 394  CYS A SG  1 
ATOM   868  N  N   . THR A 1 132 ? -34.125 -24.451 -24.580 0.34 52.38  ? 395  THR A N   1 
ATOM   869  C  CA  . THR A 1 132 ? -35.441 -24.073 -23.995 0.34 54.47  ? 395  THR A CA  1 
ATOM   870  C  C   . THR A 1 132 ? -35.685 -24.838 -22.689 0.34 55.69  ? 395  THR A C   1 
ATOM   871  O  O   . THR A 1 132 ? -35.164 -25.964 -22.552 0.34 54.78  ? 395  THR A O   1 
ATOM   872  C  CB  . THR A 1 132 ? -36.573 -24.331 -24.997 0.34 54.25  ? 395  THR A CB  1 
ATOM   873  O  OG1 . THR A 1 132 ? -36.604 -25.731 -25.279 0.34 56.11  ? 395  THR A OG1 1 
ATOM   874  C  CG2 . THR A 1 132 ? -36.407 -23.555 -26.285 0.34 54.05  ? 395  THR A CG2 1 
ATOM   875  N  N   . ARG A 1 133 ? -36.455 -24.236 -21.776 0.34 58.57  ? 396  ARG A N   1 
ATOM   876  C  CA  . ARG A 1 133 ? -36.913 -24.863 -20.508 0.34 60.15  ? 396  ARG A CA  1 
ATOM   877  C  C   . ARG A 1 133 ? -37.461 -26.260 -20.823 0.34 61.12  ? 396  ARG A C   1 
ATOM   878  O  O   . ARG A 1 133 ? -37.057 -27.229 -20.148 0.34 58.16  ? 396  ARG A O   1 
ATOM   879  C  CB  . ARG A 1 133 ? -37.963 -23.973 -19.833 0.34 61.99  ? 396  ARG A CB  1 
ATOM   880  C  CG  . ARG A 1 133 ? -37.471 -22.565 -19.524 0.34 63.84  ? 396  ARG A CG  1 
ATOM   881  C  CD  . ARG A 1 133 ? -38.488 -21.687 -18.811 0.34 65.24  ? 396  ARG A CD  1 
ATOM   882  N  NE  . ARG A 1 133 ? -37.897 -20.422 -18.388 0.34 66.17  ? 396  ARG A NE  1 
ATOM   883  C  CZ  . ARG A 1 133 ? -38.555 -19.431 -17.793 0.34 67.19  ? 396  ARG A CZ  1 
ATOM   884  N  NH1 . ARG A 1 133 ? -39.850 -19.544 -17.548 0.34 67.46  ? 396  ARG A NH1 1 
ATOM   885  N  NH2 . ARG A 1 133 ? -37.915 -18.325 -17.452 0.34 66.67  ? 396  ARG A NH2 1 
ATOM   886  N  N   . GLU A 1 134 ? -38.321 -26.351 -21.841 0.34 63.26  ? 397  GLU A N   1 
ATOM   887  C  CA  . GLU A 1 134 ? -39.040 -27.588 -22.244 0.34 65.99  ? 397  GLU A CA  1 
ATOM   888  C  C   . GLU A 1 134 ? -38.032 -28.637 -22.725 0.34 66.85  ? 397  GLU A C   1 
ATOM   889  O  O   . GLU A 1 134 ? -38.437 -29.800 -22.908 0.34 67.02  ? 397  GLU A O   1 
ATOM   890  C  CB  . GLU A 1 134 ? -40.069 -27.263 -23.328 0.34 68.98  ? 397  GLU A CB  1 
ATOM   891  C  CG  . GLU A 1 134 ? -41.309 -26.564 -22.795 0.34 71.33  ? 397  GLU A CG  1 
ATOM   892  C  CD  . GLU A 1 134 ? -41.056 -25.424 -21.819 0.34 71.91  ? 397  GLU A CD  1 
ATOM   893  O  OE1 . GLU A 1 134 ? -39.894 -24.975 -21.715 0.34 74.71  ? 397  GLU A OE1 1 
ATOM   894  O  OE2 . GLU A 1 134 ? -42.025 -24.985 -21.164 0.34 71.12  ? 397  GLU A OE2 1 
ATOM   895  N  N   . GLU A 1 135 ? -36.776 -28.228 -22.932 0.34 70.87  ? 398  GLU A N   1 
ATOM   896  C  CA  . GLU A 1 135 ? -35.639 -29.126 -23.275 0.34 72.49  ? 398  GLU A CA  1 
ATOM   897  C  C   . GLU A 1 135 ? -34.854 -29.430 -21.994 0.34 73.62  ? 398  GLU A C   1 
ATOM   898  O  O   . GLU A 1 135 ? -34.419 -30.589 -21.824 0.34 72.64  ? 398  GLU A O   1 
ATOM   899  C  CB  . GLU A 1 135 ? -34.735 -28.478 -24.327 0.34 72.12  ? 398  GLU A CB  1 
ATOM   900  C  CG  . GLU A 1 135 ? -35.386 -28.349 -25.693 0.34 72.59  ? 398  GLU A CG  1 
ATOM   901  C  CD  . GLU A 1 135 ? -34.654 -27.436 -26.662 0.34 72.07  ? 398  GLU A CD  1 
ATOM   902  O  OE1 . GLU A 1 135 ? -33.844 -26.607 -26.194 0.34 68.50  ? 398  GLU A OE1 1 
ATOM   903  O  OE2 . GLU A 1 135 ? -34.895 -27.555 -27.882 0.34 71.47  ? 398  GLU A OE2 1 
ATOM   904  N  N   . PHE A 1 136 ? -34.688 -28.415 -21.138 0.34 74.07  ? 399  PHE A N   1 
ATOM   905  C  CA  . PHE A 1 136 ? -34.000 -28.497 -19.823 0.34 75.68  ? 399  PHE A CA  1 
ATOM   906  C  C   . PHE A 1 136 ? -34.831 -29.367 -18.876 0.34 78.06  ? 399  PHE A C   1 
ATOM   907  O  O   . PHE A 1 136 ? -34.267 -30.278 -18.236 0.34 77.26  ? 399  PHE A O   1 
ATOM   908  C  CB  . PHE A 1 136 ? -33.788 -27.098 -19.240 0.34 75.47  ? 399  PHE A CB  1 
ATOM   909  C  CG  . PHE A 1 136 ? -33.015 -27.070 -17.946 0.34 74.29  ? 399  PHE A CG  1 
ATOM   910  C  CD1 . PHE A 1 136 ? -31.674 -27.418 -17.916 0.34 73.71  ? 399  PHE A CD1 1 
ATOM   911  C  CD2 . PHE A 1 136 ? -33.625 -26.692 -16.761 0.34 74.18  ? 399  PHE A CD2 1 
ATOM   912  C  CE1 . PHE A 1 136 ? -30.961 -27.389 -16.728 0.34 73.68  ? 399  PHE A CE1 1 
ATOM   913  C  CE2 . PHE A 1 136 ? -32.910 -26.663 -15.574 0.34 74.39  ? 399  PHE A CE2 1 
ATOM   914  C  CZ  . PHE A 1 136 ? -31.580 -27.011 -15.561 0.34 74.24  ? 399  PHE A CZ  1 
ATOM   915  N  N   . THR A 1 137 ? -36.134 -29.079 -18.796 0.34 80.37  ? 400  THR A N   1 
ATOM   916  C  CA  . THR A 1 137 ? -37.128 -29.829 -17.983 0.34 81.86  ? 400  THR A CA  1 
ATOM   917  C  C   . THR A 1 137 ? -37.023 -31.321 -18.317 0.34 82.36  ? 400  THR A C   1 
ATOM   918  O  O   . THR A 1 137 ? -36.749 -32.113 -17.398 0.34 82.52  ? 400  THR A O   1 
ATOM   919  C  CB  . THR A 1 137 ? -38.546 -29.293 -18.217 0.34 81.97  ? 400  THR A CB  1 
ATOM   920  O  OG1 . THR A 1 137 ? -38.609 -27.962 -17.701 0.34 82.64  ? 400  THR A OG1 1 
ATOM   921  C  CG2 . THR A 1 137 ? -39.611 -30.147 -17.567 0.34 82.10  ? 400  THR A CG2 1 
ATOM   922  N  N   . ARG A 1 138 ? -37.220 -31.678 -19.588 0.34 85.46  ? 401  ARG A N   1 
ATOM   923  C  CA  . ARG A 1 138 ? -37.182 -33.082 -20.077 0.34 89.32  ? 401  ARG A CA  1 
ATOM   924  C  C   . ARG A 1 138 ? -35.878 -33.743 -19.617 0.34 89.37  ? 401  ARG A C   1 
ATOM   925  O  O   . ARG A 1 138 ? -35.914 -34.938 -19.272 0.34 90.48  ? 401  ARG A O   1 
ATOM   926  C  CB  . ARG A 1 138 ? -37.315 -33.121 -21.602 0.34 93.76  ? 401  ARG A CB  1 
ATOM   927  C  CG  . ARG A 1 138 ? -37.260 -34.523 -22.193 0.34 96.74  ? 401  ARG A CG  1 
ATOM   928  C  CD  . ARG A 1 138 ? -37.913 -34.591 -23.560 0.34 99.15  ? 401  ARG A CD  1 
ATOM   929  N  NE  . ARG A 1 138 ? -37.500 -33.489 -24.418 0.34 101.53 ? 401  ARG A NE  1 
ATOM   930  C  CZ  . ARG A 1 138 ? -36.455 -33.522 -25.238 0.34 101.59 ? 401  ARG A CZ  1 
ATOM   931  N  NH1 . ARG A 1 138 ? -35.709 -34.611 -25.314 0.34 103.61 ? 401  ARG A NH1 1 
ATOM   932  N  NH2 . ARG A 1 138 ? -36.159 -32.468 -25.977 0.34 99.81  ? 401  ARG A NH2 1 
ATOM   933  N  N   . LYS A 1 139 ? -34.774 -32.990 -19.611 0.34 90.17  ? 402  LYS A N   1 
ATOM   934  C  CA  . LYS A 1 139 ? -33.433 -33.480 -19.193 0.34 91.77  ? 402  LYS A CA  1 
ATOM   935  C  C   . LYS A 1 139 ? -33.475 -33.867 -17.710 0.34 94.21  ? 402  LYS A C   1 
ATOM   936  O  O   . LYS A 1 139 ? -32.948 -34.945 -17.367 0.34 93.60  ? 402  LYS A O   1 
ATOM   937  C  CB  . LYS A 1 139 ? -32.361 -32.418 -19.453 0.34 91.94  ? 402  LYS A CB  1 
ATOM   938  C  CG  . LYS A 1 139 ? -32.009 -32.203 -20.919 0.34 93.18  ? 402  LYS A CG  1 
ATOM   939  C  CD  . LYS A 1 139 ? -30.890 -31.204 -21.134 0.34 93.76  ? 402  LYS A CD  1 
ATOM   940  C  CE  . LYS A 1 139 ? -29.542 -31.709 -20.665 0.34 93.72  ? 402  LYS A CE  1 
ATOM   941  N  NZ  . LYS A 1 139 ? -29.087 -32.871 -21.464 0.34 92.96  ? 402  LYS A NZ  1 
ATOM   942  N  N   . VAL A 1 140 ? -34.077 -33.020 -16.868 0.34 95.78  ? 403  VAL A N   1 
ATOM   943  C  CA  . VAL A 1 140 ? -34.185 -33.239 -15.394 0.34 97.47  ? 403  VAL A CA  1 
ATOM   944  C  C   . VAL A 1 140 ? -35.116 -34.432 -15.137 0.34 99.31  ? 403  VAL A C   1 
ATOM   945  O  O   . VAL A 1 140 ? -34.870 -35.159 -14.152 0.34 101.84 ? 403  VAL A O   1 
ATOM   946  C  CB  . VAL A 1 140 ? -34.667 -31.974 -14.655 0.34 97.81  ? 403  VAL A CB  1 
ATOM   947  C  CG1 . VAL A 1 140 ? -34.047 -30.711 -15.234 0.34 97.85  ? 403  VAL A CG1 1 
ATOM   948  C  CG2 . VAL A 1 140 ? -36.184 -31.865 -14.636 0.34 98.98  ? 403  VAL A CG2 1 
ATOM   949  N  N   . ARG A 1 141 ? -36.135 -34.625 -15.984 1.00 97.29  ? 404  ARG A N   1 
ATOM   950  C  CA  . ARG A 1 141 ? -37.085 -35.772 -15.872 1.00 98.98  ? 404  ARG A CA  1 
ATOM   951  C  C   . ARG A 1 141 ? -36.367 -37.093 -16.189 1.00 103.89 ? 404  ARG A C   1 
ATOM   952  O  O   . ARG A 1 141 ? -36.658 -38.115 -15.541 1.00 114.12 ? 404  ARG A O   1 
ATOM   953  C  CB  . ARG A 1 141 ? -38.311 -35.567 -16.766 1.00 97.39  ? 404  ARG A CB  1 
ATOM   954  C  CG  . ARG A 1 141 ? -39.263 -34.493 -16.255 1.00 109.48 ? 404  ARG A CG  1 
ATOM   955  C  CD  . ARG A 1 141 ? -40.552 -34.385 -17.059 1.00 117.42 ? 404  ARG A CD  1 
ATOM   956  N  NE  . ARG A 1 141 ? -41.255 -33.121 -16.842 1.00 118.41 ? 404  ARG A NE  1 
ATOM   957  C  CZ  . ARG A 1 141 ? -41.921 -32.783 -15.736 1.00 118.85 ? 404  ARG A CZ  1 
ATOM   958  N  NH1 . ARG A 1 141 ? -41.993 -33.616 -14.711 1.00 127.49 ? 404  ARG A NH1 1 
ATOM   959  N  NH2 . ARG A 1 141 ? -42.512 -31.603 -15.656 1.00 114.80 ? 404  ARG A NH2 1 
ATOM   960  N  N   . SER A 1 142 ? -35.429 -37.058 -17.142 0.34 105.54 ? 405  SER A N   1 
ATOM   961  C  CA  . SER A 1 142 ? -34.592 -38.213 -17.563 0.34 106.72 ? 405  SER A CA  1 
ATOM   962  C  C   . SER A 1 142 ? -33.420 -38.398 -16.591 0.34 107.16 ? 405  SER A C   1 
ATOM   963  O  O   . SER A 1 142 ? -32.749 -39.446 -16.673 0.34 107.95 ? 405  SER A O   1 
ATOM   964  C  CB  . SER A 1 142 ? -34.104 -38.035 -18.975 0.34 107.42 ? 405  SER A CB  1 
ATOM   965  O  OG  . SER A 1 142 ? -33.260 -36.898 -19.073 0.34 109.45 ? 405  SER A OG  1 
ATOM   966  N  N   . ASN A 1 143 ? -33.182 -37.412 -15.719 0.34 107.53 ? 406  ASN A N   1 
ATOM   967  C  CA  . ASN A 1 143 ? -32.107 -37.426 -14.688 0.34 107.80 ? 406  ASN A CA  1 
ATOM   968  C  C   . ASN A 1 143 ? -30.739 -37.407 -15.380 0.34 107.41 ? 406  ASN A C   1 
ATOM   969  O  O   . ASN A 1 143 ? -30.423 -38.384 -16.086 0.34 109.25 ? 406  ASN A O   1 
ATOM   970  C  CB  . ASN A 1 143 ? -32.225 -38.635 -13.756 0.34 108.24 ? 406  ASN A CB  1 
ATOM   971  C  CG  . ASN A 1 143 ? -33.464 -38.599 -12.886 0.34 108.86 ? 406  ASN A CG  1 
ATOM   972  O  OD1 . ASN A 1 143 ? -34.098 -37.556 -12.740 0.34 109.90 ? 406  ASN A OD1 1 
ATOM   973  N  ND2 . ASN A 1 143 ? -33.816 -39.732 -12.302 0.34 109.05 ? 406  ASN A ND2 1 
ATOM   974  N  N   . ALA A 1 144 ? -29.965 -36.337 -15.175 0.34 107.03 ? 407  ALA A N   1 
ATOM   975  C  CA  . ALA A 1 144 ? -28.605 -36.143 -15.733 0.34 106.31 ? 407  ALA A CA  1 
ATOM   976  C  C   . ALA A 1 144 ? -27.753 -35.349 -14.736 0.34 106.53 ? 407  ALA A C   1 
ATOM   977  O  O   . ALA A 1 144 ? -28.336 -34.726 -13.827 0.34 105.36 ? 407  ALA A O   1 
ATOM   978  C  CB  . ALA A 1 144 ? -28.691 -35.445 -17.069 0.34 104.61 ? 407  ALA A CB  1 
ATOM   979  N  N   . ALA A 1 145 ? -26.427 -35.373 -14.910 0.34 106.48 ? 408  ALA A N   1 
ATOM   980  C  CA  . ALA A 1 145 ? -25.433 -34.709 -14.033 0.34 105.38 ? 408  ALA A CA  1 
ATOM   981  C  C   . ALA A 1 145 ? -25.369 -33.211 -14.355 0.34 105.02 ? 408  ALA A C   1 
ATOM   982  O  O   . ALA A 1 145 ? -24.283 -32.734 -14.744 0.34 103.87 ? 408  ALA A O   1 
ATOM   983  C  CB  . ALA A 1 145 ? -24.085 -35.367 -14.199 0.34 104.66 ? 408  ALA A CB  1 
ATOM   984  N  N   . LEU A 1 146 ? -26.493 -32.505 -14.193 0.34 103.82 ? 409  LEU A N   1 
ATOM   985  C  CA  . LEU A 1 146 ? -26.615 -31.038 -14.411 0.34 102.46 ? 409  LEU A CA  1 
ATOM   986  C  C   . LEU A 1 146 ? -25.760 -30.302 -13.374 0.34 100.15 ? 409  LEU A C   1 
ATOM   987  O  O   . LEU A 1 146 ? -25.508 -29.096 -13.563 0.34 99.99  ? 409  LEU A O   1 
ATOM   988  C  CB  . LEU A 1 146 ? -28.087 -30.629 -14.289 0.34 104.11 ? 409  LEU A CB  1 
ATOM   989  C  CG  . LEU A 1 146 ? -29.021 -31.182 -15.365 0.34 105.77 ? 409  LEU A CG  1 
ATOM   990  C  CD1 . LEU A 1 146 ? -30.474 -30.897 -15.019 0.34 106.21 ? 409  LEU A CD1 1 
ATOM   991  C  CD2 . LEU A 1 146 ? -28.676 -30.613 -16.734 0.34 104.97 ? 409  LEU A CD2 1 
ATOM   992  N  N   . GLY A 1 147 ? -25.344 -31.011 -12.320 0.34 97.68  ? 410  GLY A N   1 
ATOM   993  C  CA  . GLY A 1 147 ? -24.528 -30.467 -11.217 0.34 96.58  ? 410  GLY A CA  1 
ATOM   994  C  C   . GLY A 1 147 ? -25.165 -29.234 -10.600 0.34 95.57  ? 410  GLY A C   1 
ATOM   995  O  O   . GLY A 1 147 ? -24.513 -28.172 -10.605 0.34 94.55  ? 410  GLY A O   1 
ATOM   996  N  N   . ALA A 1 148 ? -26.392 -29.370 -10.083 0.34 94.08  ? 411  ALA A N   1 
ATOM   997  C  CA  . ALA A 1 148 ? -27.171 -28.288 -9.433  0.34 92.78  ? 411  ALA A CA  1 
ATOM   998  C  C   . ALA A 1 148 ? -27.326 -28.589 -7.937  0.34 93.46  ? 411  ALA A C   1 
ATOM   999  O  O   . ALA A 1 148 ? -27.440 -29.780 -7.585  0.34 89.83  ? 411  ALA A O   1 
ATOM   1000 C  CB  . ALA A 1 148 ? -28.510 -28.137 -10.111 0.34 91.18  ? 411  ALA A CB  1 
ATOM   1001 N  N   . ILE A 1 149 ? -27.328 -27.546 -7.098  0.34 94.25  ? 412  ILE A N   1 
ATOM   1002 C  CA  . ILE A 1 149 ? -27.467 -27.644 -5.612  0.34 94.26  ? 412  ILE A CA  1 
ATOM   1003 C  C   . ILE A 1 149 ? -28.959 -27.674 -5.258  0.34 94.21  ? 412  ILE A C   1 
ATOM   1004 O  O   . ILE A 1 149 ? -29.771 -27.804 -6.218  0.34 93.60  ? 412  ILE A O   1 
ATOM   1005 C  CB  . ILE A 1 149 ? -26.738 -26.483 -4.902  0.34 95.01  ? 412  ILE A CB  1 
ATOM   1006 C  CG1 . ILE A 1 149 ? -27.547 -25.184 -4.951  0.34 96.76  ? 412  ILE A CG1 1 
ATOM   1007 C  CG2 . ILE A 1 149 ? -25.337 -26.298 -5.464  0.34 95.14  ? 412  ILE A CG2 1 
ATOM   1008 C  CD1 . ILE A 1 149 ? -26.936 -24.046 -4.162  0.34 96.70  ? 412  ILE A CD1 1 
ATOM   1009 N  N   . LYS A 1 155 ? -35.077 -24.711 -0.553  0.34 78.21  ? 418  LYS A N   1 
ATOM   1010 C  CA  . LYS A 1 155 ? -36.435 -24.238 -0.940  0.34 77.18  ? 418  LYS A CA  1 
ATOM   1011 C  C   . LYS A 1 155 ? -37.182 -25.381 -1.644  0.34 76.32  ? 418  LYS A C   1 
ATOM   1012 O  O   . LYS A 1 155 ? -38.331 -25.667 -1.253  0.34 73.32  ? 418  LYS A O   1 
ATOM   1013 C  CB  . LYS A 1 155 ? -36.323 -22.995 -1.829  0.34 77.52  ? 418  LYS A CB  1 
ATOM   1014 C  CG  . LYS A 1 155 ? -37.528 -22.062 -1.801  0.34 77.23  ? 418  LYS A CG  1 
ATOM   1015 C  CD  . LYS A 1 155 ? -38.812 -22.703 -2.287  0.34 76.41  ? 418  LYS A CD  1 
ATOM   1016 C  CE  . LYS A 1 155 ? -39.961 -21.721 -2.388  0.34 75.02  ? 418  LYS A CE  1 
ATOM   1017 N  NZ  . LYS A 1 155 ? -41.224 -22.393 -2.775  0.34 74.29  ? 418  LYS A NZ  1 
ATOM   1018 N  N   . TRP A 1 156 ? -36.548 -26.002 -2.645  0.34 76.16  ? 419  TRP A N   1 
ATOM   1019 C  CA  . TRP A 1 156 ? -37.047 -27.208 -3.363  0.34 75.39  ? 419  TRP A CA  1 
ATOM   1020 C  C   . TRP A 1 156 ? -36.155 -28.406 -3.025  0.34 77.39  ? 419  TRP A C   1 
ATOM   1021 O  O   . TRP A 1 156 ? -34.919 -28.267 -3.130  0.34 76.21  ? 419  TRP A O   1 
ATOM   1022 C  CB  . TRP A 1 156 ? -37.090 -26.971 -4.877  0.34 74.14  ? 419  TRP A CB  1 
ATOM   1023 C  CG  . TRP A 1 156 ? -37.987 -25.849 -5.296  0.34 71.89  ? 419  TRP A CG  1 
ATOM   1024 C  CD1 . TRP A 1 156 ? -39.335 -25.905 -5.499  0.34 70.18  ? 419  TRP A CD1 1 
ATOM   1025 C  CD2 . TRP A 1 156 ? -37.596 -24.491 -5.562  0.34 69.60  ? 419  TRP A CD2 1 
ATOM   1026 N  NE1 . TRP A 1 156 ? -39.809 -24.677 -5.875  0.34 69.75  ? 419  TRP A NE1 1 
ATOM   1027 C  CE2 . TRP A 1 156 ? -38.766 -23.790 -5.922  0.34 69.01  ? 419  TRP A CE2 1 
ATOM   1028 C  CE3 . TRP A 1 156 ? -36.378 -23.803 -5.535  0.34 69.59  ? 419  TRP A CE3 1 
ATOM   1029 C  CZ2 . TRP A 1 156 ? -38.748 -22.435 -6.248  0.34 69.74  ? 419  TRP A CZ2 1 
ATOM   1030 C  CZ3 . TRP A 1 156 ? -36.362 -22.464 -5.857  0.34 69.13  ? 419  TRP A CZ3 1 
ATOM   1031 C  CH2 . TRP A 1 156 ? -37.533 -21.792 -6.208  0.34 69.57  ? 419  TRP A CH2 1 
ATOM   1032 N  N   . LYS A 1 157 ? -36.765 -29.533 -2.646  0.34 80.57  ? 420  LYS A N   1 
ATOM   1033 C  CA  . LYS A 1 157 ? -36.064 -30.806 -2.333  0.34 83.00  ? 420  LYS A CA  1 
ATOM   1034 C  C   . LYS A 1 157 ? -35.114 -31.149 -3.487  0.34 85.50  ? 420  LYS A C   1 
ATOM   1035 O  O   . LYS A 1 157 ? -33.901 -30.878 -3.358  0.34 86.07  ? 420  LYS A O   1 
ATOM   1036 C  CB  . LYS A 1 157 ? -37.080 -31.929 -2.107  0.34 84.90  ? 420  LYS A CB  1 
ATOM   1037 C  CG  . LYS A 1 157 ? -36.480 -33.305 -1.846  0.34 85.49  ? 420  LYS A CG  1 
ATOM   1038 C  CD  . LYS A 1 157 ? -37.425 -34.445 -2.166  0.34 85.55  ? 420  LYS A CD  1 
ATOM   1039 C  CE  . LYS A 1 157 ? -38.733 -34.365 -1.409  0.34 84.48  ? 420  LYS A CE  1 
ATOM   1040 N  NZ  . LYS A 1 157 ? -39.706 -35.372 -1.895  0.34 85.15  ? 420  LYS A NZ  1 
ATOM   1041 N  N   . SER A 1 158 ? -35.659 -31.708 -4.574  0.34 86.65  ? 421  SER A N   1 
ATOM   1042 C  CA  . SER A 1 158 ? -34.912 -32.183 -5.769  0.34 86.39  ? 421  SER A CA  1 
ATOM   1043 C  C   . SER A 1 158 ? -35.028 -31.164 -6.909  0.34 88.32  ? 421  SER A C   1 
ATOM   1044 O  O   . SER A 1 158 ? -35.725 -30.143 -6.729  0.34 87.44  ? 421  SER A O   1 
ATOM   1045 C  CB  . SER A 1 158 ? -35.402 -33.540 -6.200  0.34 84.54  ? 421  SER A CB  1 
ATOM   1046 O  OG  . SER A 1 158 ? -36.807 -33.533 -6.396  0.34 84.88  ? 421  SER A OG  1 
ATOM   1047 N  N   . ALA A 1 159 ? -34.361 -31.439 -8.035  0.34 90.15  ? 422  ALA A N   1 
ATOM   1048 C  CA  . ALA A 1 159 ? -34.386 -30.613 -9.265  0.34 90.80  ? 422  ALA A CA  1 
ATOM   1049 C  C   . ALA A 1 159 ? -35.729 -30.808 -9.976  0.34 90.80  ? 422  ALA A C   1 
ATOM   1050 O  O   . ALA A 1 159 ? -36.288 -29.812 -10.474 0.34 86.83  ? 422  ALA A O   1 
ATOM   1051 C  CB  . ALA A 1 159 ? -33.228 -30.985 -10.158 0.34 91.25  ? 422  ALA A CB  1 
ATOM   1052 N  N   . ARG A 1 160 ? -36.226 -32.049 -9.999  0.34 93.17  ? 423  ARG A N   1 
ATOM   1053 C  CA  . ARG A 1 160 ? -37.512 -32.439 -10.637 0.34 96.16  ? 423  ARG A CA  1 
ATOM   1054 C  C   . ARG A 1 160 ? -38.644 -31.552 -10.099 0.34 98.68  ? 423  ARG A C   1 
ATOM   1055 O  O   . ARG A 1 160 ? -39.528 -31.188 -10.898 0.34 99.47  ? 423  ARG A O   1 
ATOM   1056 C  CB  . ARG A 1 160 ? -37.799 -33.922 -10.383 0.34 98.43  ? 423  ARG A CB  1 
ATOM   1057 C  CG  . ARG A 1 160 ? -38.909 -34.502 -11.250 0.34 102.09 ? 423  ARG A CG  1 
ATOM   1058 C  CD  . ARG A 1 160 ? -39.192 -35.960 -10.933 0.34 103.94 ? 423  ARG A CD  1 
ATOM   1059 N  NE  . ARG A 1 160 ? -38.057 -36.828 -11.220 0.34 104.85 ? 423  ARG A NE  1 
ATOM   1060 C  CZ  . ARG A 1 160 ? -37.906 -37.519 -12.344 0.34 105.74 ? 423  ARG A CZ  1 
ATOM   1061 N  NH1 . ARG A 1 160 ? -36.839 -38.281 -12.516 0.34 104.21 ? 423  ARG A NH1 1 
ATOM   1062 N  NH2 . ARG A 1 160 ? -38.823 -37.445 -13.291 0.34 106.97 ? 423  ARG A NH2 1 
ATOM   1063 N  N   . GLU A 1 161 ? -38.619 -31.225 -8.801  1.00 102.82 ? 424  GLU A N   1 
ATOM   1064 C  CA  . GLU A 1 161 ? -39.666 -30.379 -8.148  1.00 102.80 ? 424  GLU A CA  1 
ATOM   1065 C  C   . GLU A 1 161 ? -39.581 -28.914 -8.601  1.00 102.36 ? 424  GLU A C   1 
ATOM   1066 O  O   . GLU A 1 161 ? -40.623 -28.374 -9.014  1.00 109.93 ? 424  GLU A O   1 
ATOM   1067 C  CB  . GLU A 1 161 ? -39.531 -30.395 -6.624  1.00 109.04 ? 424  GLU A CB  1 
ATOM   1068 C  CG  . GLU A 1 161 ? -40.078 -31.645 -5.960  1.00 115.07 ? 424  GLU A CG  1 
ATOM   1069 C  CD  . GLU A 1 161 ? -40.121 -31.566 -4.441  1.00 117.86 ? 424  GLU A CD  1 
ATOM   1070 O  OE1 . GLU A 1 161 ? -39.613 -30.563 -3.882  1.00 116.24 ? 424  GLU A OE1 1 
ATOM   1071 O  OE2 . GLU A 1 161 ? -40.666 -32.505 -3.817  1.00 109.34 ? 424  GLU A OE2 1 
ATOM   1072 N  N   . ALA A 1 162 ? -38.403 -28.289 -8.478  1.00 95.07  ? 425  ALA A N   1 
ATOM   1073 C  CA  . ALA A 1 162 ? -38.140 -26.856 -8.772  1.00 88.33  ? 425  ALA A CA  1 
ATOM   1074 C  C   . ALA A 1 162 ? -38.569 -26.481 -10.200 1.00 88.31  ? 425  ALA A C   1 
ATOM   1075 O  O   . ALA A 1 162 ? -39.064 -25.356 -10.421 1.00 83.05  ? 425  ALA A O   1 
ATOM   1076 C  CB  . ALA A 1 162 ? -36.674 -26.566 -8.563  1.00 89.90  ? 425  ALA A CB  1 
ATOM   1077 N  N   . VAL A 1 163 ? -38.363 -27.407 -11.142 0.34 91.04  ? 426  VAL A N   1 
ATOM   1078 C  CA  . VAL A 1 163 ? -38.699 -27.269 -12.591 0.34 94.71  ? 426  VAL A CA  1 
ATOM   1079 C  C   . VAL A 1 163 ? -40.196 -26.976 -12.749 0.34 97.47  ? 426  VAL A C   1 
ATOM   1080 O  O   . VAL A 1 163 ? -40.544 -26.161 -13.627 0.34 97.70  ? 426  VAL A O   1 
ATOM   1081 C  CB  . VAL A 1 163 ? -38.292 -28.537 -13.368 0.34 94.94  ? 426  VAL A CB  1 
ATOM   1082 C  CG1 . VAL A 1 163 ? -39.295 -28.884 -14.456 0.34 95.65  ? 426  VAL A CG1 1 
ATOM   1083 C  CG2 . VAL A 1 163 ? -36.888 -28.420 -13.942 0.34 95.14  ? 426  VAL A CG2 1 
ATOM   1084 N  N   . GLU A 1 164 ? -41.037 -27.614 -11.927 1.00 101.65 ? 427  GLU A N   1 
ATOM   1085 C  CA  . GLU A 1 164 ? -42.525 -27.475 -11.986 1.00 104.27 ? 427  GLU A CA  1 
ATOM   1086 C  C   . GLU A 1 164 ? -43.027 -26.190 -11.293 1.00 100.19 ? 427  GLU A C   1 
ATOM   1087 O  O   . GLU A 1 164 ? -44.033 -25.612 -11.751 1.00 104.59 ? 427  GLU A O   1 
ATOM   1088 C  CB  . GLU A 1 164 ? -43.179 -28.739 -11.416 1.00 110.64 ? 427  GLU A CB  1 
ATOM   1089 C  CG  . GLU A 1 164 ? -43.314 -29.851 -12.445 1.00 119.07 ? 427  GLU A CG  1 
ATOM   1090 C  CD  . GLU A 1 164 ? -42.858 -31.227 -11.988 1.00 131.11 ? 427  GLU A CD  1 
ATOM   1091 O  OE1 . GLU A 1 164 ? -43.264 -31.656 -10.889 1.00 143.21 ? 427  GLU A OE1 1 
ATOM   1092 O  OE2 . GLU A 1 164 ? -42.087 -31.862 -12.734 1.00 140.22 ? 427  GLU A OE2 1 
ATOM   1093 N  N   . ASP A 1 165 ? -42.352 -25.756 -10.223 0.34 101.89 ? 428  ASP A N   1 
ATOM   1094 C  CA  . ASP A 1 165 ? -42.717 -24.539 -9.448  0.34 102.10 ? 428  ASP A CA  1 
ATOM   1095 C  C   . ASP A 1 165 ? -42.291 -23.289 -10.230 0.34 100.58 ? 428  ASP A C   1 
ATOM   1096 O  O   . ASP A 1 165 ? -41.071 -23.074 -10.388 0.34 100.00 ? 428  ASP A O   1 
ATOM   1097 C  CB  . ASP A 1 165 ? -42.096 -24.560 -8.049  0.34 103.66 ? 428  ASP A CB  1 
ATOM   1098 C  CG  . ASP A 1 165 ? -42.488 -23.364 -7.198  0.34 104.45 ? 428  ASP A CG  1 
ATOM   1099 O  OD1 . ASP A 1 165 ? -42.716 -22.284 -7.779  0.34 102.29 ? 428  ASP A OD1 1 
ATOM   1100 O  OD2 . ASP A 1 165 ? -42.569 -23.525 -5.962  0.34 106.27 ? 428  ASP A OD2 1 
ATOM   1101 N  N   . SER A 1 166 ? -43.266 -22.494 -10.684 0.34 98.13  ? 429  SER A N   1 
ATOM   1102 C  CA  . SER A 1 166 ? -43.068 -21.277 -11.514 0.34 96.36  ? 429  SER A CA  1 
ATOM   1103 C  C   . SER A 1 166 ? -42.285 -20.222 -10.725 0.34 93.73  ? 429  SER A C   1 
ATOM   1104 O  O   . SER A 1 166 ? -41.661 -19.351 -11.364 0.34 93.98  ? 429  SER A O   1 
ATOM   1105 C  CB  . SER A 1 166 ? -44.386 -20.733 -11.999 0.34 99.23  ? 429  SER A CB  1 
ATOM   1106 O  OG  . SER A 1 166 ? -45.061 -21.690 -12.803 0.34 101.16 ? 429  SER A OG  1 
ATOM   1107 N  N   . GLY A 1 167 ? -42.329 -20.293 -9.391  0.34 91.54  ? 430  GLY A N   1 
ATOM   1108 C  CA  . GLY A 1 167 ? -41.555 -19.414 -8.493  0.34 88.84  ? 430  GLY A CA  1 
ATOM   1109 C  C   . GLY A 1 167 ? -40.086 -19.426 -8.870  0.34 87.53  ? 430  GLY A C   1 
ATOM   1110 O  O   . GLY A 1 167 ? -39.462 -18.352 -8.858  0.34 85.53  ? 430  GLY A O   1 
ATOM   1111 N  N   . PHE A 1 168 ? -39.565 -20.610 -9.203  0.34 87.40  ? 431  PHE A N   1 
ATOM   1112 C  CA  . PHE A 1 168 ? -38.193 -20.839 -9.725  0.34 87.88  ? 431  PHE A CA  1 
ATOM   1113 C  C   . PHE A 1 168 ? -38.007 -20.026 -11.010 0.34 84.96  ? 431  PHE A C   1 
ATOM   1114 O  O   . PHE A 1 168 ? -37.096 -19.181 -11.059 0.34 85.63  ? 431  PHE A O   1 
ATOM   1115 C  CB  . PHE A 1 168 ? -37.965 -22.337 -9.953  0.34 89.98  ? 431  PHE A CB  1 
ATOM   1116 C  CG  . PHE A 1 168 ? -36.714 -22.692 -10.716 0.34 90.60  ? 431  PHE A CG  1 
ATOM   1117 C  CD1 . PHE A 1 168 ? -35.497 -22.827 -10.066 0.34 90.93  ? 431  PHE A CD1 1 
ATOM   1118 C  CD2 . PHE A 1 168 ? -36.757 -22.911 -12.084 0.34 91.57  ? 431  PHE A CD2 1 
ATOM   1119 C  CE1 . PHE A 1 168 ? -34.350 -23.162 -10.769 0.34 90.48  ? 431  PHE A CE1 1 
ATOM   1120 C  CE2 . PHE A 1 168 ? -35.609 -23.244 -12.785 0.34 91.76  ? 431  PHE A CE2 1 
ATOM   1121 C  CZ  . PHE A 1 168 ? -34.409 -23.370 -12.127 0.34 91.55  ? 431  PHE A CZ  1 
ATOM   1122 N  N   . TRP A 1 169 ? -38.863 -20.262 -12.009 0.34 82.82  ? 432  TRP A N   1 
ATOM   1123 C  CA  . TRP A 1 169 ? -38.789 -19.621 -13.350 0.34 82.26  ? 432  TRP A CA  1 
ATOM   1124 C  C   . TRP A 1 169 ? -38.874 -18.096 -13.206 0.34 82.63  ? 432  TRP A C   1 
ATOM   1125 O  O   . TRP A 1 169 ? -38.301 -17.388 -14.058 0.34 82.56  ? 432  TRP A O   1 
ATOM   1126 C  CB  . TRP A 1 169 ? -39.873 -20.178 -14.280 0.34 80.23  ? 432  TRP A CB  1 
ATOM   1127 C  CG  . TRP A 1 169 ? -39.656 -21.612 -14.656 0.34 80.55  ? 432  TRP A CG  1 
ATOM   1128 C  CD1 . TRP A 1 169 ? -40.525 -22.649 -14.479 0.34 81.22  ? 432  TRP A CD1 1 
ATOM   1129 C  CD2 . TRP A 1 169 ? -38.477 -22.180 -15.257 0.34 81.10  ? 432  TRP A CD2 1 
ATOM   1130 N  NE1 . TRP A 1 169 ? -39.975 -23.816 -14.937 0.34 81.67  ? 432  TRP A NE1 1 
ATOM   1131 C  CE2 . TRP A 1 169 ? -38.719 -23.560 -15.419 0.34 80.77  ? 432  TRP A CE2 1 
ATOM   1132 C  CE3 . TRP A 1 169 ? -37.247 -21.660 -15.677 0.34 80.77  ? 432  TRP A CE3 1 
ATOM   1133 C  CZ2 . TRP A 1 169 ? -37.777 -24.421 -15.981 0.34 80.73  ? 432  TRP A CZ2 1 
ATOM   1134 C  CZ3 . TRP A 1 169 ? -36.318 -22.511 -16.234 0.34 80.63  ? 432  TRP A CZ3 1 
ATOM   1135 C  CH2 . TRP A 1 169 ? -36.582 -23.873 -16.383 0.34 79.67  ? 432  TRP A CH2 1 
ATOM   1136 N  N   . GLU A 1 170 ? -39.553 -17.611 -12.163 0.34 83.45  ? 433  GLU A N   1 
ATOM   1137 C  CA  . GLU A 1 170 ? -39.627 -16.165 -11.819 0.34 83.67  ? 433  GLU A CA  1 
ATOM   1138 C  C   . GLU A 1 170 ? -38.230 -15.690 -11.401 0.34 80.03  ? 433  GLU A C   1 
ATOM   1139 O  O   . GLU A 1 170 ? -37.795 -14.629 -11.892 0.34 79.28  ? 433  GLU A O   1 
ATOM   1140 C  CB  . GLU A 1 170 ? -40.668 -15.934 -10.721 0.34 85.79  ? 433  GLU A CB  1 
ATOM   1141 C  CG  . GLU A 1 170 ? -42.081 -16.309 -11.139 0.34 88.58  ? 433  GLU A CG  1 
ATOM   1142 C  CD  . GLU A 1 170 ? -43.046 -16.568 -9.993  0.34 90.74  ? 433  GLU A CD  1 
ATOM   1143 O  OE1 . GLU A 1 170 ? -42.794 -16.060 -8.879  0.34 92.55  ? 433  GLU A OE1 1 
ATOM   1144 O  OE2 . GLU A 1 170 ? -44.048 -17.284 -10.213 0.34 88.03  ? 433  GLU A OE2 1 
ATOM   1145 N  N   . LEU A 1 171 ? -37.560 -16.459 -10.534 1.00 77.77  ? 434  LEU A N   1 
ATOM   1146 C  CA  . LEU A 1 171 ? -36.167 -16.181 -10.072 1.00 79.21  ? 434  LEU A CA  1 
ATOM   1147 C  C   . LEU A 1 171 ? -35.247 -16.176 -11.299 1.00 80.25  ? 434  LEU A C   1 
ATOM   1148 O  O   . LEU A 1 171 ? -34.435 -15.227 -11.441 1.00 67.13  ? 434  LEU A O   1 
ATOM   1149 C  CB  . LEU A 1 171 ? -35.678 -17.235 -9.069  1.00 78.59  ? 434  LEU A CB  1 
ATOM   1150 C  CG  . LEU A 1 171 ? -36.486 -17.416 -7.783  1.00 82.57  ? 434  LEU A CG  1 
ATOM   1151 C  CD1 . LEU A 1 171 ? -35.928 -18.572 -6.960  1.00 80.56  ? 434  LEU A CD1 1 
ATOM   1152 C  CD2 . LEU A 1 171 ? -36.502 -16.137 -6.956  1.00 81.36  ? 434  LEU A CD2 1 
ATOM   1153 N  N   . VAL A 1 172 ? -35.409 -17.187 -12.162 1.00 73.30  ? 435  VAL A N   1 
ATOM   1154 C  CA  . VAL A 1 172 ? -34.658 -17.334 -13.441 1.00 69.97  ? 435  VAL A CA  1 
ATOM   1155 C  C   . VAL A 1 172 ? -34.842 -16.065 -14.280 1.00 71.19  ? 435  VAL A C   1 
ATOM   1156 O  O   . VAL A 1 172 ? -33.830 -15.510 -14.768 1.00 66.92  ? 435  VAL A O   1 
ATOM   1157 C  CB  . VAL A 1 172 ? -35.068 -18.601 -14.211 1.00 74.56  ? 435  VAL A CB  1 
ATOM   1158 C  CG1 . VAL A 1 172 ? -34.387 -18.660 -15.566 1.00 76.91  ? 435  VAL A CG1 1 
ATOM   1159 C  CG2 . VAL A 1 172 ? -34.776 -19.871 -13.419 1.00 76.57  ? 435  VAL A CG2 1 
ATOM   1160 N  N   . ASP A 1 173 ? -36.093 -15.609 -14.426 0.34 70.06  ? 436  ASP A N   1 
ATOM   1161 C  CA  . ASP A 1 173 ? -36.468 -14.395 -15.203 0.34 69.60  ? 436  ASP A CA  1 
ATOM   1162 C  C   . ASP A 1 173 ? -35.697 -13.184 -14.662 0.34 67.98  ? 436  ASP A C   1 
ATOM   1163 O  O   . ASP A 1 173 ? -35.074 -12.469 -15.474 0.34 68.50  ? 436  ASP A O   1 
ATOM   1164 C  CB  . ASP A 1 173 ? -37.979 -14.153 -15.164 0.34 72.01  ? 436  ASP A CB  1 
ATOM   1165 C  CG  . ASP A 1 173 ? -38.782 -15.139 -15.997 0.34 74.55  ? 436  ASP A CG  1 
ATOM   1166 O  OD1 . ASP A 1 173 ? -38.234 -15.641 -17.003 0.34 74.76  ? 436  ASP A OD1 1 
ATOM   1167 O  OD2 . ASP A 1 173 ? -39.949 -15.401 -15.631 0.34 75.12  ? 436  ASP A OD2 1 
ATOM   1168 N  N   . LYS A 1 174 ? -35.733 -12.970 -13.343 0.34 66.29  ? 437  LYS A N   1 
ATOM   1169 C  CA  . LYS A 1 174 ? -35.053 -11.831 -12.667 0.34 65.00  ? 437  LYS A CA  1 
ATOM   1170 C  C   . LYS A 1 174 ? -33.568 -11.847 -13.046 0.34 63.83  ? 437  LYS A C   1 
ATOM   1171 O  O   . LYS A 1 174 ? -33.083 -10.836 -13.598 0.34 62.36  ? 437  LYS A O   1 
ATOM   1172 C  CB  . LYS A 1 174 ? -35.248 -11.917 -11.150 0.34 66.14  ? 437  LYS A CB  1 
ATOM   1173 C  CG  . LYS A 1 174 ? -34.619 -10.786 -10.347 0.34 67.65  ? 437  LYS A CG  1 
ATOM   1174 C  CD  . LYS A 1 174 ? -34.826 -10.926 -8.852  0.34 68.33  ? 437  LYS A CD  1 
ATOM   1175 C  CE  . LYS A 1 174 ? -34.006 -9.945  -8.041  0.34 68.58  ? 437  LYS A CE  1 
ATOM   1176 N  NZ  . LYS A 1 174 ? -34.192 -10.157 -6.586  0.34 69.72  ? 437  LYS A NZ  1 
ATOM   1177 N  N   . GLU A 1 175 ? -32.885 -12.963 -12.766 0.34 62.89  ? 438  GLU A N   1 
ATOM   1178 C  CA  . GLU A 1 175 ? -31.450 -13.183 -13.093 0.34 60.84  ? 438  GLU A CA  1 
ATOM   1179 C  C   . GLU A 1 175 ? -31.226 -12.927 -14.586 0.34 58.23  ? 438  GLU A C   1 
ATOM   1180 O  O   . GLU A 1 175 ? -30.383 -12.068 -14.923 0.34 54.97  ? 438  GLU A O   1 
ATOM   1181 C  CB  . GLU A 1 175 ? -31.032 -14.605 -12.718 0.34 61.59  ? 438  GLU A CB  1 
ATOM   1182 C  CG  . GLU A 1 175 ? -30.091 -14.657 -11.531 0.34 62.13  ? 438  GLU A CG  1 
ATOM   1183 C  CD  . GLU A 1 175 ? -28.715 -14.083 -11.811 0.34 60.29  ? 438  GLU A CD  1 
ATOM   1184 O  OE1 . GLU A 1 175 ? -28.020 -14.632 -12.688 0.34 59.74  ? 438  GLU A OE1 1 
ATOM   1185 O  OE2 . GLU A 1 175 ? -28.350 -13.082 -11.165 0.34 59.02  ? 438  GLU A OE2 1 
ATOM   1186 N  N   . ARG A 1 176 ? -31.959 -13.655 -15.433 0.34 57.04  ? 439  ARG A N   1 
ATOM   1187 C  CA  . ARG A 1 176 ? -31.912 -13.543 -16.914 0.34 57.89  ? 439  ARG A CA  1 
ATOM   1188 C  C   . ARG A 1 176 ? -31.902 -12.063 -17.305 0.34 57.90  ? 439  ARG A C   1 
ATOM   1189 O  O   . ARG A 1 176 ? -30.945 -11.637 -17.980 0.34 58.99  ? 439  ARG A O   1 
ATOM   1190 C  CB  . ARG A 1 176 ? -33.115 -14.272 -17.517 0.34 59.26  ? 439  ARG A CB  1 
ATOM   1191 C  CG  . ARG A 1 176 ? -33.101 -14.377 -19.033 0.34 60.38  ? 439  ARG A CG  1 
ATOM   1192 C  CD  . ARG A 1 176 ? -33.992 -15.523 -19.464 0.34 62.22  ? 439  ARG A CD  1 
ATOM   1193 N  NE  . ARG A 1 176 ? -34.319 -15.484 -20.878 0.34 66.75  ? 439  ARG A NE  1 
ATOM   1194 C  CZ  . ARG A 1 176 ? -35.014 -16.422 -21.507 0.34 71.23  ? 439  ARG A CZ  1 
ATOM   1195 N  NH1 . ARG A 1 176 ? -35.447 -17.477 -20.836 0.34 70.19  ? 439  ARG A NH1 1 
ATOM   1196 N  NH2 . ARG A 1 176 ? -35.271 -16.301 -22.799 0.34 72.23  ? 439  ARG A NH2 1 
ATOM   1197 N  N   . ASN A 1 177 ? -32.924 -11.315 -16.874 0.34 58.81  ? 440  ASN A N   1 
ATOM   1198 C  CA  . ASN A 1 177 ? -33.119 -9.875  -17.195 0.34 58.08  ? 440  ASN A CA  1 
ATOM   1199 C  C   . ASN A 1 177 ? -31.942 -9.068  -16.633 0.34 57.69  ? 440  ASN A C   1 
ATOM   1200 O  O   . ASN A 1 177 ? -31.604 -8.027  -17.228 0.34 57.89  ? 440  ASN A O   1 
ATOM   1201 C  CB  . ASN A 1 177 ? -34.476 -9.377  -16.692 0.34 59.08  ? 440  ASN A CB  1 
ATOM   1202 C  CG  . ASN A 1 177 ? -35.641 -10.093 -17.347 0.34 58.42  ? 440  ASN A CG  1 
ATOM   1203 O  OD1 . ASN A 1 177 ? -35.450 -10.994 -18.164 0.34 54.77  ? 440  ASN A OD1 1 
ATOM   1204 N  ND2 . ASN A 1 177 ? -36.853 -9.701  -16.993 0.34 58.97  ? 440  ASN A ND2 1 
ATOM   1205 N  N   . LEU A 1 178 ? -31.331 -9.541  -15.542 0.34 59.88  ? 441  LEU A N   1 
ATOM   1206 C  CA  . LEU A 1 178 ? -30.093 -8.955  -14.959 0.34 61.23  ? 441  LEU A CA  1 
ATOM   1207 C  C   . LEU A 1 178 ? -28.929 -9.135  -15.942 0.34 61.14  ? 441  LEU A C   1 
ATOM   1208 O  O   . LEU A 1 178 ? -28.167 -8.165  -16.137 0.34 60.21  ? 441  LEU A O   1 
ATOM   1209 C  CB  . LEU A 1 178 ? -29.790 -9.627  -13.616 0.34 62.72  ? 441  LEU A CB  1 
ATOM   1210 C  CG  . LEU A 1 178 ? -30.436 -8.972  -12.397 0.34 65.07  ? 441  LEU A CG  1 
ATOM   1211 C  CD1 . LEU A 1 178 ? -30.103 -9.741  -11.126 0.34 66.44  ? 441  LEU A CD1 1 
ATOM   1212 C  CD2 . LEU A 1 178 ? -30.005 -7.518  -12.269 0.34 65.96  ? 441  LEU A CD2 1 
ATOM   1213 N  N   . HIS A 1 179 ? -28.798 -10.326 -16.536 0.34 61.51  ? 442  HIS A N   1 
ATOM   1214 C  CA  . HIS A 1 179 ? -27.720 -10.670 -17.505 0.34 63.66  ? 442  HIS A CA  1 
ATOM   1215 C  C   . HIS A 1 179 ? -27.816 -9.757  -18.735 0.34 63.89  ? 442  HIS A C   1 
ATOM   1216 O  O   . HIS A 1 179 ? -26.754 -9.365  -19.256 0.34 64.00  ? 442  HIS A O   1 
ATOM   1217 C  CB  . HIS A 1 179 ? -27.769 -12.160 -17.879 0.34 64.32  ? 442  HIS A CB  1 
ATOM   1218 C  CG  . HIS A 1 179 ? -27.288 -13.076 -16.802 0.34 64.71  ? 442  HIS A CG  1 
ATOM   1219 N  ND1 . HIS A 1 179 ? -27.710 -14.391 -16.706 0.34 64.00  ? 442  HIS A ND1 1 
ATOM   1220 C  CD2 . HIS A 1 179 ? -26.435 -12.876 -15.772 0.34 63.96  ? 442  HIS A CD2 1 
ATOM   1221 C  CE1 . HIS A 1 179 ? -27.132 -14.960 -15.668 0.34 64.49  ? 442  HIS A CE1 1 
ATOM   1222 N  NE2 . HIS A 1 179 ? -26.344 -14.051 -15.077 0.34 64.12  ? 442  HIS A NE2 1 
ATOM   1223 N  N   . LEU A 1 180 ? -29.037 -9.430  -19.177 0.34 66.71  ? 443  LEU A N   1 
ATOM   1224 C  CA  . LEU A 1 180 ? -29.301 -8.467  -20.284 0.34 66.83  ? 443  LEU A CA  1 
ATOM   1225 C  C   . LEU A 1 180 ? -28.877 -7.067  -19.826 0.34 66.85  ? 443  LEU A C   1 
ATOM   1226 O  O   . LEU A 1 180 ? -28.484 -6.251  -20.681 0.34 65.58  ? 443  LEU A O   1 
ATOM   1227 C  CB  . LEU A 1 180 ? -30.788 -8.508  -20.656 0.34 66.78  ? 443  LEU A CB  1 
ATOM   1228 C  CG  . LEU A 1 180 ? -31.301 -9.844  -21.196 0.34 67.52  ? 443  LEU A CG  1 
ATOM   1229 C  CD1 . LEU A 1 180 ? -32.818 -9.841  -21.306 0.34 68.21  ? 443  LEU A CD1 1 
ATOM   1230 C  CD2 . LEU A 1 180 ? -30.674 -10.170 -22.543 0.34 68.03  ? 443  LEU A CD2 1 
ATOM   1231 N  N   . GLU A 1 181 ? -28.934 -6.830  -18.512 0.34 69.93  ? 444  GLU A N   1 
ATOM   1232 C  CA  . GLU A 1 181 ? -28.532 -5.568  -17.832 0.34 72.95  ? 444  GLU A CA  1 
ATOM   1233 C  C   . GLU A 1 181 ? -26.997 -5.473  -17.781 0.34 76.27  ? 444  GLU A C   1 
ATOM   1234 O  O   . GLU A 1 181 ? -26.481 -4.363  -17.535 0.34 78.73  ? 444  GLU A O   1 
ATOM   1235 C  CB  . GLU A 1 181 ? -29.135 -5.554  -16.423 0.34 71.30  ? 444  GLU A CB  1 
ATOM   1236 C  CG  . GLU A 1 181 ? -29.997 -4.339  -16.117 0.34 69.12  ? 444  GLU A CG  1 
ATOM   1237 C  CD  . GLU A 1 181 ? -30.848 -4.469  -14.861 0.34 67.15  ? 444  GLU A CD  1 
ATOM   1238 O  OE1 . GLU A 1 181 ? -30.519 -3.810  -13.850 0.34 62.41  ? 444  GLU A OE1 1 
ATOM   1239 O  OE2 . GLU A 1 181 ? -31.845 -5.223  -14.897 0.34 63.90  ? 444  GLU A OE2 1 
ATOM   1240 N  N   . GLY A 1 182 ? -26.304 -6.598  -18.004 1.00 81.14  ? 445  GLY A N   1 
ATOM   1241 C  CA  . GLY A 1 182 ? -24.838 -6.732  -17.849 1.00 71.27  ? 445  GLY A CA  1 
ATOM   1242 C  C   . GLY A 1 182 ? -24.422 -6.965  -16.406 1.00 62.18  ? 445  GLY A C   1 
ATOM   1243 O  O   . GLY A 1 182 ? -23.284 -6.627  -16.059 1.00 65.20  ? 445  GLY A O   1 
ATOM   1244 N  N   . LYS A 1 183 ? -25.301 -7.536  -15.590 1.00 58.51  ? 446  LYS A N   1 
ATOM   1245 C  CA  . LYS A 1 183 ? -25.104 -7.692  -14.123 1.00 67.98  ? 446  LYS A CA  1 
ATOM   1246 C  C   . LYS A 1 183 ? -25.458 -9.126  -13.715 1.00 57.51  ? 446  LYS A C   1 
ATOM   1247 O  O   . LYS A 1 183 ? -26.257 -9.744  -14.411 1.00 50.92  ? 446  LYS A O   1 
ATOM   1248 C  CB  . LYS A 1 183 ? -26.004 -6.734  -13.328 1.00 77.01  ? 446  LYS A CB  1 
ATOM   1249 C  CG  . LYS A 1 183 ? -25.894 -5.257  -13.685 1.00 82.94  ? 446  LYS A CG  1 
ATOM   1250 C  CD  . LYS A 1 183 ? -27.079 -4.438  -13.201 1.00 89.08  ? 446  LYS A CD  1 
ATOM   1251 C  CE  . LYS A 1 183 ? -27.317 -3.208  -14.049 1.00 98.04  ? 446  LYS A CE  1 
ATOM   1252 N  NZ  . LYS A 1 183 ? -26.195 -2.245  -13.956 1.00 106.07 ? 446  LYS A NZ  1 
ATOM   1253 N  N   . CYS A 1 184 ? -24.927 -9.594  -12.582 1.00 63.77  ? 447  CYS A N   1 
ATOM   1254 C  CA  . CYS A 1 184 ? -25.120 -10.967 -12.042 1.00 64.98  ? 447  CYS A CA  1 
ATOM   1255 C  C   . CYS A 1 184 ? -25.371 -10.888 -10.527 1.00 62.03  ? 447  CYS A C   1 
ATOM   1256 O  O   . CYS A 1 184 ? -24.651 -10.119 -9.850  1.00 63.96  ? 447  CYS A O   1 
ATOM   1257 C  CB  . CYS A 1 184 ? -23.900 -11.837 -12.362 1.00 62.94  ? 447  CYS A CB  1 
ATOM   1258 S  SG  . CYS A 1 184 ? -24.147 -13.600 -12.005 1.00 62.76  ? 447  CYS A SG  1 
ATOM   1259 N  N   . GLU A 1 185 ? -26.301 -11.695 -10.004 1.00 63.89  ? 448  GLU A N   1 
ATOM   1260 C  CA  . GLU A 1 185 ? -26.686 -11.680 -8.565  1.00 72.85  ? 448  GLU A CA  1 
ATOM   1261 C  C   . GLU A 1 185 ? -26.473 -13.058 -7.920  1.00 73.04  ? 448  GLU A C   1 
ATOM   1262 O  O   . GLU A 1 185 ? -25.915 -13.088 -6.803  1.00 73.13  ? 448  GLU A O   1 
ATOM   1263 C  CB  . GLU A 1 185 ? -28.136 -11.202 -8.414  1.00 84.10  ? 448  GLU A CB  1 
ATOM   1264 C  CG  . GLU A 1 185 ? -28.556 -10.926 -6.976  1.00 87.27  ? 448  GLU A CG  1 
ATOM   1265 C  CD  . GLU A 1 185 ? -30.017 -10.537 -6.786  1.00 94.74  ? 448  GLU A CD  1 
ATOM   1266 O  OE1 . GLU A 1 185 ? -30.386 -9.432  -7.236  1.00 101.73 ? 448  GLU A OE1 1 
ATOM   1267 O  OE2 . GLU A 1 185 ? -30.793 -11.343 -6.199  1.00 92.40  ? 448  GLU A OE2 1 
ATOM   1268 N  N   . THR A 1 186 ? -26.910 -14.151 -8.554  1.00 64.87  ? 449  THR A N   1 
ATOM   1269 C  CA  . THR A 1 186 ? -27.033 -15.468 -7.878  1.00 68.13  ? 449  THR A CA  1 
ATOM   1270 C  C   . THR A 1 186 ? -26.193 -16.562 -8.551  1.00 64.17  ? 449  THR A C   1 
ATOM   1271 O  O   . THR A 1 186 ? -26.298 -17.701 -8.089  1.00 74.62  ? 449  THR A O   1 
ATOM   1272 C  CB  . THR A 1 186 ? -28.502 -15.896 -7.790  1.00 77.68  ? 449  THR A CB  1 
ATOM   1273 O  OG1 . THR A 1 186 ? -28.979 -16.230 -9.092  1.00 80.19  ? 449  THR A OG1 1 
ATOM   1274 C  CG2 . THR A 1 186 ? -29.389 -14.825 -7.196  1.00 85.39  ? 449  THR A CG2 1 
ATOM   1275 N  N   . CYS A 1 187 ? -25.389 -16.258 -9.574  1.00 62.92  ? 450  CYS A N   1 
ATOM   1276 C  CA  . CYS A 1 187 ? -24.580 -17.266 -10.317 1.00 56.88  ? 450  CYS A CA  1 
ATOM   1277 C  C   . CYS A 1 187 ? -23.228 -17.464 -9.604  1.00 57.30  ? 450  CYS A C   1 
ATOM   1278 O  O   . CYS A 1 187 ? -22.218 -16.823 -9.976  1.00 49.40  ? 450  CYS A O   1 
ATOM   1279 C  CB  . CYS A 1 187 ? -24.465 -16.878 -11.785 1.00 54.40  ? 450  CYS A CB  1 
ATOM   1280 S  SG  . CYS A 1 187 ? -26.090 -16.667 -12.575 1.00 63.75  ? 450  CYS A SG  1 
ATOM   1281 N  N   . VAL A 1 188 ? -23.224 -18.352 -8.607  1.00 62.90  ? 451  VAL A N   1 
ATOM   1282 C  CA  . VAL A 1 188 ? -22.082 -18.588 -7.673  1.00 68.44  ? 451  VAL A CA  1 
ATOM   1283 C  C   . VAL A 1 188 ? -21.691 -20.074 -7.658  1.00 61.25  ? 451  VAL A C   1 
ATOM   1284 O  O   . VAL A 1 188 ? -22.576 -20.956 -7.560  1.00 56.90  ? 451  VAL A O   1 
ATOM   1285 C  CB  . VAL A 1 188 ? -22.437 -18.086 -6.263  1.00 72.21  ? 451  VAL A CB  1 
ATOM   1286 C  CG1 . VAL A 1 188 ? -21.486 -18.641 -5.208  1.00 79.04  ? 451  VAL A CG1 1 
ATOM   1287 C  CG2 . VAL A 1 188 ? -22.464 -16.564 -6.236  1.00 72.96  ? 451  VAL A CG2 1 
ATOM   1288 N  N   . TYR A 1 189 ? -20.392 -20.341 -7.729  1.00 62.45  ? 452  TYR A N   1 
ATOM   1289 C  CA  . TYR A 1 189 ? -19.852 -21.723 -7.739  1.00 71.24  ? 452  TYR A CA  1 
ATOM   1290 C  C   . TYR A 1 189 ? -19.720 -22.219 -6.294  1.00 71.54  ? 452  TYR A C   1 
ATOM   1291 O  O   . TYR A 1 189 ? -19.533 -21.400 -5.382  1.00 71.76  ? 452  TYR A O   1 
ATOM   1292 C  CB  . TYR A 1 189 ? -18.576 -21.774 -8.584  1.00 72.02  ? 452  TYR A CB  1 
ATOM   1293 C  CG  . TYR A 1 189 ? -18.848 -21.681 -10.064 1.00 71.08  ? 452  TYR A CG  1 
ATOM   1294 C  CD1 . TYR A 1 189 ? -19.561 -22.677 -10.710 1.00 73.35  ? 452  TYR A CD1 1 
ATOM   1295 C  CD2 . TYR A 1 189 ? -18.440 -20.583 -10.809 1.00 71.37  ? 452  TYR A CD2 1 
ATOM   1296 C  CE1 . TYR A 1 189 ? -19.848 -22.597 -12.061 1.00 78.00  ? 452  TYR A CE1 1 
ATOM   1297 C  CE2 . TYR A 1 189 ? -18.698 -20.496 -12.167 1.00 69.45  ? 452  TYR A CE2 1 
ATOM   1298 C  CZ  . TYR A 1 189 ? -19.426 -21.497 -12.789 1.00 75.82  ? 452  TYR A CZ  1 
ATOM   1299 O  OH  . TYR A 1 189 ? -19.702 -21.426 -14.124 1.00 88.19  ? 452  TYR A OH  1 
ATOM   1300 N  N   . ASN A 1 190 ? -19.915 -23.528 -6.108  1.00 78.62  ? 453  ASN A N   1 
ATOM   1301 C  CA  . ASN A 1 190 ? -19.706 -24.280 -4.841  1.00 81.37  ? 453  ASN A CA  1 
ATOM   1302 C  C   . ASN A 1 190 ? -18.680 -25.392 -5.098  1.00 81.31  ? 453  ASN A C   1 
ATOM   1303 O  O   . ASN A 1 190 ? -19.026 -26.320 -5.846  1.00 77.38  ? 453  ASN A O   1 
ATOM   1304 C  CB  . ASN A 1 190 ? -21.026 -24.855 -4.324  1.00 77.09  ? 453  ASN A CB  1 
ATOM   1305 C  CG  . ASN A 1 190 ? -22.088 -23.796 -4.120  1.00 76.45  ? 453  ASN A CG  1 
ATOM   1306 O  OD1 . ASN A 1 190 ? -22.019 -22.714 -4.693  1.00 87.64  ? 453  ASN A OD1 1 
ATOM   1307 N  ND2 . ASN A 1 190 ? -23.075 -24.092 -3.295  1.00 72.84  ? 453  ASN A ND2 1 
ATOM   1308 N  N   . MET A 1 191 ? -17.469 -25.287 -4.531  1.00 94.16  ? 454  MET A N   1 
ATOM   1309 C  CA  . MET A 1 191 ? -16.322 -26.202 -4.809  1.00 109.26 ? 454  MET A CA  1 
ATOM   1310 C  C   . MET A 1 191 ? -16.491 -27.494 -4.000  1.00 116.52 ? 454  MET A C   1 
ATOM   1311 O  O   . MET A 1 191 ? -17.032 -27.406 -2.884  1.00 124.29 ? 454  MET A O   1 
ATOM   1312 C  CB  . MET A 1 191 ? -14.986 -25.541 -4.453  1.00 114.29 ? 454  MET A CB  1 
ATOM   1313 C  CG  . MET A 1 191 ? -13.771 -26.355 -4.870  1.00 129.45 ? 454  MET A CG  1 
ATOM   1314 S  SD  . MET A 1 191 ? -12.332 -25.336 -5.310  1.00 154.62 ? 454  MET A SD  1 
ATOM   1315 C  CE  . MET A 1 191 ? -12.825 -24.772 -6.938  1.00 149.82 ? 454  MET A CE  1 
ATOM   1316 N  N   . MET A 1 192 ? -16.050 -28.636 -4.555  1.00 124.79 ? 455  MET A N   1 
ATOM   1317 C  CA  . MET A 1 192 ? -16.202 -30.009 -3.982  1.00 121.64 ? 455  MET A CA  1 
ATOM   1318 C  C   . MET A 1 192 ? -15.428 -31.010 -4.856  1.00 123.93 ? 455  MET A C   1 
ATOM   1319 O  O   . MET A 1 192 ? -15.391 -32.208 -4.486  1.00 120.04 ? 455  MET A O   1 
ATOM   1320 C  CB  . MET A 1 192 ? -17.679 -30.425 -3.915  1.00 115.58 ? 455  MET A CB  1 
ATOM   1321 C  CG  . MET A 1 192 ? -18.357 -30.124 -2.586  1.00 108.15 ? 455  MET A CG  1 
ATOM   1322 S  SD  . MET A 1 192 ? -20.112 -29.694 -2.771  1.00 109.89 ? 455  MET A SD  1 
ATOM   1323 C  CE  . MET A 1 192 ? -20.886 -31.276 -2.432  1.00 105.50 ? 455  MET A CE  1 
ATOM   1324 N  N   . ILE A 1 211 ? -15.231 -30.293 -8.515  1.00 103.66 ? 474  ILE A N   1 
ATOM   1325 C  CA  . ILE A 1 211 ? -16.587 -30.197 -9.141  1.00 99.42  ? 474  ILE A CA  1 
ATOM   1326 C  C   . ILE A 1 211 ? -17.307 -28.943 -8.634  1.00 100.09 ? 474  ILE A C   1 
ATOM   1327 O  O   . ILE A 1 211 ? -17.440 -28.786 -7.407  1.00 101.20 ? 474  ILE A O   1 
ATOM   1328 C  CB  . ILE A 1 211 ? -17.417 -31.467 -8.870  1.00 99.36  ? 474  ILE A CB  1 
ATOM   1329 C  CG1 . ILE A 1 211 ? -16.542 -32.725 -8.827  1.00 108.94 ? 474  ILE A CG1 1 
ATOM   1330 C  CG2 . ILE A 1 211 ? -18.547 -31.593 -9.886  1.00 89.81  ? 474  ILE A CG2 1 
ATOM   1331 C  CD1 . ILE A 1 211 ? -15.972 -33.058 -7.456  1.00 116.53 ? 474  ILE A CD1 1 
ATOM   1332 N  N   . TRP A 1 212 ? -17.772 -28.107 -9.567  1.00 95.49  ? 475  TRP A N   1 
ATOM   1333 C  CA  . TRP A 1 212 ? -18.289 -26.736 -9.330  1.00 95.03  ? 475  TRP A CA  1 
ATOM   1334 C  C   . TRP A 1 212 ? -19.804 -26.731 -9.548  1.00 93.67  ? 475  TRP A C   1 
ATOM   1335 O  O   . TRP A 1 212 ? -20.232 -26.399 -10.670 1.00 102.66 ? 475  TRP A O   1 
ATOM   1336 C  CB  . TRP A 1 212 ? -17.589 -25.734 -10.259 1.00 97.23  ? 475  TRP A CB  1 
ATOM   1337 C  CG  . TRP A 1 212 ? -16.096 -25.722 -10.157 1.00 100.29 ? 475  TRP A CG  1 
ATOM   1338 C  CD1 . TRP A 1 212 ? -15.268 -26.792 -9.988  1.00 109.47 ? 475  TRP A CD1 1 
ATOM   1339 C  CD2 . TRP A 1 212 ? -15.239 -24.575 -10.256 1.00 100.12 ? 475  TRP A CD2 1 
ATOM   1340 N  NE1 . TRP A 1 212 ? -13.963 -26.389 -9.949  1.00 112.54 ? 475  TRP A NE1 1 
ATOM   1341 C  CE2 . TRP A 1 212 ? -13.912 -25.034 -10.115 1.00 101.82 ? 475  TRP A CE2 1 
ATOM   1342 C  CE3 . TRP A 1 212 ? -15.460 -23.210 -10.440 1.00 92.89  ? 475  TRP A CE3 1 
ATOM   1343 C  CZ2 . TRP A 1 212 ? -12.813 -24.182 -10.161 1.00 97.47  ? 475  TRP A CZ2 1 
ATOM   1344 C  CZ3 . TRP A 1 212 ? -14.375 -22.367 -10.491 1.00 97.35  ? 475  TRP A CZ3 1 
ATOM   1345 C  CH2 . TRP A 1 212 ? -13.071 -22.847 -10.357 1.00 101.40 ? 475  TRP A CH2 1 
ATOM   1346 N  N   . TYR A 1 213 ? -20.577 -27.096 -8.523  1.00 88.38  ? 476  TYR A N   1 
ATOM   1347 C  CA  . TYR A 1 213 ? -22.061 -27.009 -8.521  1.00 88.59  ? 476  TYR A CA  1 
ATOM   1348 C  C   . TYR A 1 213 ? -22.471 -25.532 -8.410  1.00 81.93  ? 476  TYR A C   1 
ATOM   1349 O  O   . TYR A 1 213 ? -21.884 -24.825 -7.573  1.00 84.57  ? 476  TYR A O   1 
ATOM   1350 C  CB  . TYR A 1 213 ? -22.655 -27.842 -7.378  1.00 92.29  ? 476  TYR A CB  1 
ATOM   1351 C  CG  . TYR A 1 213 ? -22.238 -29.294 -7.345  1.00 97.14  ? 476  TYR A CG  1 
ATOM   1352 C  CD1 . TYR A 1 213 ? -22.407 -30.116 -8.448  1.00 104.15 ? 476  TYR A CD1 1 
ATOM   1353 C  CD2 . TYR A 1 213 ? -21.692 -29.860 -6.202  1.00 104.46 ? 476  TYR A CD2 1 
ATOM   1354 C  CE1 . TYR A 1 213 ? -22.035 -31.452 -8.427  1.00 104.09 ? 476  TYR A CE1 1 
ATOM   1355 C  CE2 . TYR A 1 213 ? -21.319 -31.195 -6.159  1.00 102.92 ? 476  TYR A CE2 1 
ATOM   1356 C  CZ  . TYR A 1 213 ? -21.487 -31.994 -7.277  1.00 105.94 ? 476  TYR A CZ  1 
ATOM   1357 O  OH  . TYR A 1 213 ? -21.118 -33.308 -7.241  1.00 108.43 ? 476  TYR A OH  1 
ATOM   1358 N  N   . MET A 1 214 ? -23.393 -25.073 -9.267  1.00 79.40  ? 477  MET A N   1 
ATOM   1359 C  CA  . MET A 1 214 ? -24.227 -23.849 -9.067  1.00 79.13  ? 477  MET A CA  1 
ATOM   1360 C  C   . MET A 1 214 ? -25.642 -24.345 -8.839  1.00 69.21  ? 477  MET A C   1 
ATOM   1361 O  O   . MET A 1 214 ? -25.872 -25.522 -9.029  1.00 65.80  ? 477  MET A O   1 
ATOM   1362 C  CB  . MET A 1 214 ? -24.261 -22.935 -10.292 1.00 80.41  ? 477  MET A CB  1 
ATOM   1363 C  CG  . MET A 1 214 ? -22.933 -22.783 -10.962 1.00 86.93  ? 477  MET A CG  1 
ATOM   1364 S  SD  . MET A 1 214 ? -23.115 -21.762 -12.427 1.00 93.97  ? 477  MET A SD  1 
ATOM   1365 C  CE  . MET A 1 214 ? -22.575 -20.182 -11.774 1.00 79.51  ? 477  MET A CE  1 
ATOM   1366 N  N   . TRP A 1 215 ? -26.560 -23.455 -8.449  0.34 70.63  ? 478  TRP A N   1 
ATOM   1367 C  CA  . TRP A 1 215 ? -27.996 -23.793 -8.255  0.34 70.83  ? 478  TRP A CA  1 
ATOM   1368 C  C   . TRP A 1 215 ? -28.663 -23.961 -9.627  0.34 68.84  ? 478  TRP A C   1 
ATOM   1369 O  O   . TRP A 1 215 ? -28.183 -23.347 -10.601 0.34 65.37  ? 478  TRP A O   1 
ATOM   1370 C  CB  . TRP A 1 215 ? -28.700 -22.753 -7.372  0.34 71.32  ? 478  TRP A CB  1 
ATOM   1371 C  CG  . TRP A 1 215 ? -29.088 -21.486 -8.069  0.34 72.91  ? 478  TRP A CG  1 
ATOM   1372 C  CD1 . TRP A 1 215 ? -28.252 -20.511 -8.531  0.34 75.42  ? 478  TRP A CD1 1 
ATOM   1373 C  CD2 . TRP A 1 215 ? -30.425 -21.035 -8.353  0.34 73.33  ? 478  TRP A CD2 1 
ATOM   1374 N  NE1 . TRP A 1 215 ? -28.975 -19.495 -9.097  0.34 76.88  ? 478  TRP A NE1 1 
ATOM   1375 C  CE2 . TRP A 1 215 ? -30.310 -19.787 -9.002  0.34 75.17  ? 478  TRP A CE2 1 
ATOM   1376 C  CE3 . TRP A 1 215 ? -31.701 -21.566 -8.133  0.34 72.38  ? 478  TRP A CE3 1 
ATOM   1377 C  CZ2 . TRP A 1 215 ? -31.423 -19.065 -9.429  0.34 74.31  ? 478  TRP A CZ2 1 
ATOM   1378 C  CZ3 . TRP A 1 215 ? -32.799 -20.853 -8.558  0.34 73.28  ? 478  TRP A CZ3 1 
ATOM   1379 C  CH2 . TRP A 1 215 ? -32.660 -19.619 -9.196  0.34 74.31  ? 478  TRP A CH2 1 
ATOM   1380 N  N   . LEU A 1 216 ? -29.712 -24.786 -9.691  0.34 68.15  ? 479  LEU A N   1 
ATOM   1381 C  CA  . LEU A 1 216 ? -30.382 -25.227 -10.944 0.34 68.54  ? 479  LEU A CA  1 
ATOM   1382 C  C   . LEU A 1 216 ? -30.613 -24.030 -11.877 0.34 68.76  ? 479  LEU A C   1 
ATOM   1383 O  O   . LEU A 1 216 ? -30.414 -24.195 -13.096 0.34 69.79  ? 479  LEU A O   1 
ATOM   1384 C  CB  . LEU A 1 216 ? -31.704 -25.908 -10.581 0.34 68.73  ? 479  LEU A CB  1 
ATOM   1385 C  CG  . LEU A 1 216 ? -32.247 -26.873 -11.633 0.34 69.72  ? 479  LEU A CG  1 
ATOM   1386 C  CD1 . LEU A 1 216 ? -31.192 -27.895 -12.024 0.34 69.54  ? 479  LEU A CD1 1 
ATOM   1387 C  CD2 . LEU A 1 216 ? -33.506 -27.566 -11.134 0.34 70.26  ? 479  LEU A CD2 1 
ATOM   1388 N  N   . GLY A 1 217 ? -31.030 -22.885 -11.325 1.00 68.24  ? 480  GLY A N   1 
ATOM   1389 C  CA  . GLY A 1 217 ? -31.305 -21.657 -12.098 1.00 67.10  ? 480  GLY A CA  1 
ATOM   1390 C  C   . GLY A 1 217 ? -30.120 -21.156 -12.907 1.00 66.30  ? 480  GLY A C   1 
ATOM   1391 O  O   . GLY A 1 217 ? -30.303 -20.879 -14.114 1.00 66.93  ? 480  GLY A O   1 
ATOM   1392 N  N   . ALA A 1 218 ? -28.945 -21.026 -12.288 1.00 61.56  ? 481  ALA A N   1 
ATOM   1393 C  CA  . ALA A 1 218 ? -27.689 -20.657 -12.990 1.00 58.87  ? 481  ALA A CA  1 
ATOM   1394 C  C   . ALA A 1 218 ? -27.358 -21.692 -14.083 1.00 56.34  ? 481  ALA A C   1 
ATOM   1395 O  O   . ALA A 1 218 ? -26.905 -21.287 -15.171 1.00 53.09  ? 481  ALA A O   1 
ATOM   1396 C  CB  . ALA A 1 218 ? -26.565 -20.500 -12.008 1.00 54.83  ? 481  ALA A CB  1 
ATOM   1397 N  N   . ARG A 1 219 ? -27.588 -22.980 -13.796 0.34 55.94  ? 482  ARG A N   1 
ATOM   1398 C  CA  . ARG A 1 219 ? -27.341 -24.113 -14.730 0.34 57.45  ? 482  ARG A CA  1 
ATOM   1399 C  C   . ARG A 1 219 ? -28.219 -23.958 -15.974 0.34 55.60  ? 482  ARG A C   1 
ATOM   1400 O  O   . ARG A 1 219 ? -27.712 -24.214 -17.084 0.34 55.21  ? 482  ARG A O   1 
ATOM   1401 C  CB  . ARG A 1 219 ? -27.607 -25.462 -14.055 0.34 60.37  ? 482  ARG A CB  1 
ATOM   1402 C  CG  . ARG A 1 219 ? -26.343 -26.256 -13.755 0.34 65.44  ? 482  ARG A CG  1 
ATOM   1403 C  CD  . ARG A 1 219 ? -25.387 -25.487 -12.861 0.34 68.14  ? 482  ARG A CD  1 
ATOM   1404 N  NE  . ARG A 1 219 ? -24.057 -26.080 -12.774 0.34 69.62  ? 482  ARG A NE  1 
ATOM   1405 C  CZ  . ARG A 1 219 ? -22.965 -25.568 -13.330 0.34 70.99  ? 482  ARG A CZ  1 
ATOM   1406 N  NH1 . ARG A 1 219 ? -23.036 -24.447 -14.028 0.34 72.51  ? 482  ARG A NH1 1 
ATOM   1407 N  NH2 . ARG A 1 219 ? -21.801 -26.176 -13.183 0.34 73.31  ? 482  ARG A NH2 1 
ATOM   1408 N  N   . PHE A 1 220 ? -29.481 -23.554 -15.798 0.34 54.33  ? 483  PHE A N   1 
ATOM   1409 C  CA  . PHE A 1 220 ? -30.435 -23.330 -16.914 0.34 52.13  ? 483  PHE A CA  1 
ATOM   1410 C  C   . PHE A 1 220 ? -29.924 -22.200 -17.810 0.34 50.45  ? 483  PHE A C   1 
ATOM   1411 O  O   . PHE A 1 220 ? -29.912 -22.365 -19.041 0.34 51.36  ? 483  PHE A O   1 
ATOM   1412 C  CB  . PHE A 1 220 ? -31.838 -22.963 -16.429 0.34 51.89  ? 483  PHE A CB  1 
ATOM   1413 C  CG  . PHE A 1 220 ? -32.692 -22.414 -17.541 0.34 50.46  ? 483  PHE A CG  1 
ATOM   1414 C  CD1 . PHE A 1 220 ? -33.293 -23.265 -18.454 0.34 51.29  ? 483  PHE A CD1 1 
ATOM   1415 C  CD2 . PHE A 1 220 ? -32.832 -21.048 -17.720 0.34 51.09  ? 483  PHE A CD2 1 
ATOM   1416 C  CE1 . PHE A 1 220 ? -34.053 -22.761 -19.497 0.34 52.49  ? 483  PHE A CE1 1 
ATOM   1417 C  CE2 . PHE A 1 220 ? -33.592 -20.546 -18.764 0.34 52.15  ? 483  PHE A CE2 1 
ATOM   1418 C  CZ  . PHE A 1 220 ? -34.202 -21.403 -19.650 0.34 52.02  ? 483  PHE A CZ  1 
ATOM   1419 N  N   . LEU A 1 221 ? -29.546 -21.073 -17.203 0.34 50.84  ? 484  LEU A N   1 
ATOM   1420 C  CA  . LEU A 1 221 ? -29.098 -19.854 -17.926 0.34 52.08  ? 484  LEU A CA  1 
ATOM   1421 C  C   . LEU A 1 221 ? -27.820 -20.174 -18.709 0.34 52.13  ? 484  LEU A C   1 
ATOM   1422 O  O   . LEU A 1 221 ? -27.630 -19.588 -19.794 0.34 52.68  ? 484  LEU A O   1 
ATOM   1423 C  CB  . LEU A 1 221 ? -28.884 -18.720 -16.921 0.34 52.29  ? 484  LEU A CB  1 
ATOM   1424 C  CG  . LEU A 1 221 ? -30.156 -17.989 -16.489 0.34 54.02  ? 484  LEU A CG  1 
ATOM   1425 C  CD1 . LEU A 1 221 ? -29.833 -16.855 -15.528 0.34 55.03  ? 484  LEU A CD1 1 
ATOM   1426 C  CD2 . LEU A 1 221 ? -30.914 -17.461 -17.697 0.34 54.28  ? 484  LEU A CD2 1 
ATOM   1427 N  N   . GLU A 1 222 ? -26.988 -21.077 -18.179 0.34 51.57  ? 485  GLU A N   1 
ATOM   1428 C  CA  . GLU A 1 222 ? -25.778 -21.599 -18.868 0.34 50.65  ? 485  GLU A CA  1 
ATOM   1429 C  C   . GLU A 1 222 ? -26.216 -22.465 -20.055 0.34 48.84  ? 485  GLU A C   1 
ATOM   1430 O  O   . GLU A 1 222 ? -25.732 -22.222 -21.177 0.34 47.81  ? 485  GLU A O   1 
ATOM   1431 C  CB  . GLU A 1 222 ? -24.909 -22.405 -17.901 0.34 50.46  ? 485  GLU A CB  1 
ATOM   1432 C  CG  . GLU A 1 222 ? -23.614 -22.880 -18.529 0.34 52.20  ? 485  GLU A CG  1 
ATOM   1433 C  CD  . GLU A 1 222 ? -23.017 -24.125 -17.898 0.34 52.21  ? 485  GLU A CD  1 
ATOM   1434 O  OE1 . GLU A 1 222 ? -22.000 -23.992 -17.191 0.34 53.77  ? 485  GLU A OE1 1 
ATOM   1435 O  OE2 . GLU A 1 222 ? -23.562 -25.222 -18.127 0.34 51.28  ? 485  GLU A OE2 1 
ATOM   1436 N  N   . PHE A 1 223 ? -27.108 -23.430 -19.805 1.00 48.13  ? 486  PHE A N   1 
ATOM   1437 C  CA  . PHE A 1 223 ? -27.654 -24.363 -20.832 1.00 48.84  ? 486  PHE A CA  1 
ATOM   1438 C  C   . PHE A 1 223 ? -28.397 -23.630 -21.947 1.00 50.02  ? 486  PHE A C   1 
ATOM   1439 O  O   . PHE A 1 223 ? -28.285 -24.028 -23.122 1.00 47.94  ? 486  PHE A O   1 
ATOM   1440 C  CB  . PHE A 1 223 ? -28.587 -25.359 -20.155 1.00 48.44  ? 486  PHE A CB  1 
ATOM   1441 C  CG  . PHE A 1 223 ? -29.387 -26.232 -21.081 1.00 51.57  ? 486  PHE A CG  1 
ATOM   1442 C  CD1 . PHE A 1 223 ? -28.810 -27.344 -21.674 1.00 46.90  ? 486  PHE A CD1 1 
ATOM   1443 C  CD2 . PHE A 1 223 ? -30.733 -25.971 -21.310 1.00 50.73  ? 486  PHE A CD2 1 
ATOM   1444 C  CE1 . PHE A 1 223 ? -29.547 -28.145 -22.534 1.00 53.24  ? 486  PHE A CE1 1 
ATOM   1445 C  CE2 . PHE A 1 223 ? -31.479 -26.797 -22.137 1.00 51.16  ? 486  PHE A CE2 1 
ATOM   1446 C  CZ  . PHE A 1 223 ? -30.886 -27.881 -22.754 1.00 54.85  ? 486  PHE A CZ  1 
ATOM   1447 N  N   . GLU A 1 224 ? -29.139 -22.583 -21.577 0.34 50.99  ? 487  GLU A N   1 
ATOM   1448 C  CA  . GLU A 1 224 ? -29.927 -21.721 -22.500 0.34 52.18  ? 487  GLU A CA  1 
ATOM   1449 C  C   . GLU A 1 224 ? -28.990 -21.094 -23.540 0.34 51.01  ? 487  GLU A C   1 
ATOM   1450 O  O   . GLU A 1 224 ? -29.334 -21.121 -24.737 0.34 51.42  ? 487  GLU A O   1 
ATOM   1451 C  CB  . GLU A 1 224 ? -30.679 -20.655 -21.697 0.34 54.26  ? 487  GLU A CB  1 
ATOM   1452 C  CG  . GLU A 1 224 ? -31.135 -19.464 -22.523 0.34 55.39  ? 487  GLU A CG  1 
ATOM   1453 C  CD  . GLU A 1 224 ? -32.264 -18.658 -21.897 0.34 56.42  ? 487  GLU A CD  1 
ATOM   1454 O  OE1 . GLU A 1 224 ? -33.355 -19.230 -21.702 0.34 57.50  ? 487  GLU A OE1 1 
ATOM   1455 O  OE2 . GLU A 1 224 ? -32.050 -17.463 -21.602 0.34 55.15  ? 487  GLU A OE2 1 
ATOM   1456 N  N   . ALA A 1 225 ? -27.844 -20.571 -23.096 1.00 49.48  ? 488  ALA A N   1 
ATOM   1457 C  CA  . ALA A 1 225 ? -26.897 -19.829 -23.955 1.00 49.20  ? 488  ALA A CA  1 
ATOM   1458 C  C   . ALA A 1 225 ? -25.962 -20.759 -24.732 1.00 47.23  ? 488  ALA A C   1 
ATOM   1459 O  O   . ALA A 1 225 ? -25.605 -20.361 -25.857 1.00 45.51  ? 488  ALA A O   1 
ATOM   1460 C  CB  . ALA A 1 225 ? -26.135 -18.842 -23.118 1.00 48.55  ? 488  ALA A CB  1 
ATOM   1461 N  N   . LEU A 1 226 ? -25.554 -21.904 -24.160 1.00 43.51  ? 489  LEU A N   1 
ATOM   1462 C  CA  . LEU A 1 226 ? -24.375 -22.681 -24.640 1.00 41.87  ? 489  LEU A CA  1 
ATOM   1463 C  C   . LEU A 1 226 ? -24.689 -24.172 -24.829 1.00 38.39  ? 489  LEU A C   1 
ATOM   1464 O  O   . LEU A 1 226 ? -23.840 -24.878 -25.426 1.00 39.50  ? 489  LEU A O   1 
ATOM   1465 C  CB  . LEU A 1 226 ? -23.209 -22.468 -23.666 1.00 43.27  ? 489  LEU A CB  1 
ATOM   1466 C  CG  . LEU A 1 226 ? -22.692 -21.034 -23.539 1.00 45.72  ? 489  LEU A CG  1 
ATOM   1467 C  CD1 . LEU A 1 226 ? -21.572 -20.924 -22.503 1.00 48.93  ? 489  LEU A CD1 1 
ATOM   1468 C  CD2 . LEU A 1 226 ? -22.178 -20.525 -24.872 1.00 50.64  ? 489  LEU A CD2 1 
ATOM   1469 N  N   . GLY A 1 227 ? -25.870 -24.638 -24.423 1.00 33.72  ? 490  GLY A N   1 
ATOM   1470 C  CA  . GLY A 1 227 ? -26.329 -26.034 -24.601 1.00 33.17  ? 490  GLY A CA  1 
ATOM   1471 C  C   . GLY A 1 227 ? -26.297 -26.485 -26.049 1.00 32.22  ? 490  GLY A C   1 
ATOM   1472 O  O   . GLY A 1 227 ? -26.125 -27.711 -26.323 1.00 36.67  ? 490  GLY A O   1 
ATOM   1473 N  N   . PHE A 1 228 ? -26.461 -25.555 -26.989 1.00 33.42  ? 491  PHE A N   1 
ATOM   1474 C  CA  . PHE A 1 228 ? -26.474 -25.914 -28.428 1.00 34.06  ? 491  PHE A CA  1 
ATOM   1475 C  C   . PHE A 1 228 ? -25.189 -26.689 -28.752 1.00 32.40  ? 491  PHE A C   1 
ATOM   1476 O  O   . PHE A 1 228 ? -25.276 -27.550 -29.599 1.00 31.36  ? 491  PHE A O   1 
ATOM   1477 C  CB  . PHE A 1 228 ? -26.654 -24.699 -29.341 1.00 34.02  ? 491  PHE A CB  1 
ATOM   1478 C  CG  . PHE A 1 228 ? -25.502 -23.743 -29.397 1.00 31.71  ? 491  PHE A CG  1 
ATOM   1479 C  CD1 . PHE A 1 228 ? -25.369 -22.740 -28.460 1.00 36.30  ? 491  PHE A CD1 1 
ATOM   1480 C  CD2 . PHE A 1 228 ? -24.538 -23.861 -30.376 1.00 35.10  ? 491  PHE A CD2 1 
ATOM   1481 C  CE1 . PHE A 1 228 ? -24.302 -21.859 -28.514 1.00 35.79  ? 491  PHE A CE1 1 
ATOM   1482 C  CE2 . PHE A 1 228 ? -23.464 -22.984 -30.428 1.00 34.58  ? 491  PHE A CE2 1 
ATOM   1483 C  CZ  . PHE A 1 228 ? -23.330 -22.002 -29.482 1.00 35.63  ? 491  PHE A CZ  1 
ATOM   1484 N  N   . LEU A 1 229 ? -24.055 -26.365 -28.110 1.00 36.77  ? 492  LEU A N   1 
ATOM   1485 C  CA  . LEU A 1 229 ? -22.735 -26.982 -28.420 1.00 38.26  ? 492  LEU A CA  1 
ATOM   1486 C  C   . LEU A 1 229 ? -22.862 -28.505 -28.306 1.00 36.42  ? 492  LEU A C   1 
ATOM   1487 O  O   . LEU A 1 229 ? -22.491 -29.221 -29.259 1.00 35.24  ? 492  LEU A O   1 
ATOM   1488 C  CB  . LEU A 1 229 ? -21.681 -26.416 -27.463 1.00 38.51  ? 492  LEU A CB  1 
ATOM   1489 C  CG  . LEU A 1 229 ? -21.229 -24.980 -27.737 1.00 40.64  ? 492  LEU A CG  1 
ATOM   1490 C  CD1 . LEU A 1 229 ? -20.261 -24.526 -26.660 1.00 42.07  ? 492  LEU A CD1 1 
ATOM   1491 C  CD2 . LEU A 1 229 ? -20.603 -24.843 -29.118 1.00 40.78  ? 492  LEU A CD2 1 
ATOM   1492 N  N   . ASN A 1 230 ? -23.439 -28.974 -27.204 1.00 36.30  ? 493  ASN A N   1 
ATOM   1493 C  CA  . ASN A 1 230 ? -23.664 -30.423 -26.962 1.00 39.55  ? 493  ASN A CA  1 
ATOM   1494 C  C   . ASN A 1 230 ? -24.959 -30.881 -27.644 1.00 38.98  ? 493  ASN A C   1 
ATOM   1495 O  O   . ASN A 1 230 ? -24.909 -31.868 -28.412 1.00 38.73  ? 493  ASN A O   1 
ATOM   1496 C  CB  . ASN A 1 230 ? -23.698 -30.730 -25.460 1.00 43.63  ? 493  ASN A CB  1 
ATOM   1497 C  CG  . ASN A 1 230 ? -23.846 -32.217 -25.220 1.00 49.96  ? 493  ASN A CG  1 
ATOM   1498 O  OD1 . ASN A 1 230 ? -24.871 -32.679 -24.722 1.00 57.10  ? 493  ASN A OD1 1 
ATOM   1499 N  ND2 . ASN A 1 230 ? -22.855 -32.977 -25.648 1.00 47.97  ? 493  ASN A ND2 1 
ATOM   1500 N  N   . GLU A 1 231 ? -26.084 -30.191 -27.384 1.00 40.91  ? 494  GLU A N   1 
ATOM   1501 C  CA  . GLU A 1 231 ? -27.423 -30.588 -27.918 1.00 38.58  ? 494  GLU A CA  1 
ATOM   1502 C  C   . GLU A 1 231 ? -27.355 -30.769 -29.451 1.00 37.23  ? 494  GLU A C   1 
ATOM   1503 O  O   . GLU A 1 231 ? -27.994 -31.715 -29.938 1.00 35.21  ? 494  GLU A O   1 
ATOM   1504 C  CB  . GLU A 1 231 ? -28.493 -29.555 -27.544 1.00 41.96  ? 494  GLU A CB  1 
ATOM   1505 C  CG  . GLU A 1 231 ? -28.966 -29.588 -26.089 1.00 41.43  ? 494  GLU A CG  1 
ATOM   1506 C  CD  . GLU A 1 231 ? -29.187 -30.966 -25.483 1.00 54.78  ? 494  GLU A CD  1 
ATOM   1507 O  OE1 . GLU A 1 231 ? -30.102 -31.696 -25.971 1.00 57.40  ? 494  GLU A OE1 1 
ATOM   1508 O  OE2 . GLU A 1 231 ? -28.407 -31.332 -24.549 1.00 61.59  ? 494  GLU A OE2 1 
ATOM   1509 N  N   . ASP A 1 232 ? -26.594 -29.932 -30.187 1.00 34.71  ? 495  ASP A N   1 
ATOM   1510 C  CA  . ASP A 1 232 ? -26.547 -29.960 -31.678 1.00 34.57  ? 495  ASP A CA  1 
ATOM   1511 C  C   . ASP A 1 232 ? -25.208 -30.520 -32.196 1.00 37.92  ? 495  ASP A C   1 
ATOM   1512 O  O   . ASP A 1 232 ? -24.935 -30.393 -33.428 1.00 34.67  ? 495  ASP A O   1 
ATOM   1513 C  CB  . ASP A 1 232 ? -26.848 -28.567 -32.239 1.00 39.55  ? 495  ASP A CB  1 
ATOM   1514 C  CG  . ASP A 1 232 ? -28.236 -28.068 -31.855 1.00 36.81  ? 495  ASP A CG  1 
ATOM   1515 O  OD1 . ASP A 1 232 ? -29.058 -28.903 -31.527 1.00 39.50  ? 495  ASP A OD1 1 
ATOM   1516 O  OD2 . ASP A 1 232 ? -28.461 -26.855 -31.856 1.00 41.12  ? 495  ASP A OD2 1 
ATOM   1517 N  N   . HIS A 1 233 ? -24.420 -31.181 -31.338 1.00 38.02  ? 496  HIS A N   1 
ATOM   1518 C  CA  . HIS A 1 233 ? -23.301 -32.062 -31.775 1.00 38.10  ? 496  HIS A CA  1 
ATOM   1519 C  C   . HIS A 1 233 ? -22.254 -31.262 -32.570 1.00 31.68  ? 496  HIS A C   1 
ATOM   1520 O  O   . HIS A 1 233 ? -21.846 -31.691 -33.637 1.00 32.11  ? 496  HIS A O   1 
ATOM   1521 C  CB  . HIS A 1 233 ? -23.882 -33.207 -32.599 1.00 40.86  ? 496  HIS A CB  1 
ATOM   1522 C  CG  . HIS A 1 233 ? -24.960 -33.948 -31.895 1.00 49.38  ? 496  HIS A CG  1 
ATOM   1523 N  ND1 . HIS A 1 233 ? -24.770 -34.515 -30.649 1.00 59.39  ? 496  HIS A ND1 1 
ATOM   1524 C  CD2 . HIS A 1 233 ? -26.250 -34.182 -32.225 1.00 50.84  ? 496  HIS A CD2 1 
ATOM   1525 C  CE1 . HIS A 1 233 ? -25.893 -35.093 -30.255 1.00 55.63  ? 496  HIS A CE1 1 
ATOM   1526 N  NE2 . HIS A 1 233 ? -26.807 -34.906 -31.204 1.00 48.29  ? 496  HIS A NE2 1 
ATOM   1527 N  N   . TRP A 1 234 ? -21.835 -30.118 -32.065 1.00 30.39  ? 497  TRP A N   1 
ATOM   1528 C  CA  . TRP A 1 234 ? -20.797 -29.258 -32.702 1.00 34.89  ? 497  TRP A CA  1 
ATOM   1529 C  C   . TRP A 1 234 ? -19.448 -30.006 -32.743 1.00 35.04  ? 497  TRP A C   1 
ATOM   1530 O  O   . TRP A 1 234 ? -18.708 -29.845 -33.742 1.00 32.58  ? 497  TRP A O   1 
ATOM   1531 C  CB  . TRP A 1 234 ? -20.708 -27.899 -31.993 1.00 34.03  ? 497  TRP A CB  1 
ATOM   1532 C  CG  . TRP A 1 234 ? -21.738 -26.925 -32.488 1.00 40.75  ? 497  TRP A CG  1 
ATOM   1533 C  CD1 . TRP A 1 234 ? -23.088 -27.140 -32.565 1.00 42.15  ? 497  TRP A CD1 1 
ATOM   1534 C  CD2 . TRP A 1 234 ? -21.517 -25.611 -33.032 1.00 42.04  ? 497  TRP A CD2 1 
ATOM   1535 N  NE1 . TRP A 1 234 ? -23.710 -26.057 -33.121 1.00 42.08  ? 497  TRP A NE1 1 
ATOM   1536 C  CE2 . TRP A 1 234 ? -22.785 -25.092 -33.392 1.00 44.56  ? 497  TRP A CE2 1 
ATOM   1537 C  CE3 . TRP A 1 234 ? -20.391 -24.804 -33.225 1.00 42.57  ? 497  TRP A CE3 1 
ATOM   1538 C  CZ2 . TRP A 1 234 ? -22.953 -23.812 -33.923 1.00 42.74  ? 497  TRP A CZ2 1 
ATOM   1539 C  CZ3 . TRP A 1 234 ? -20.555 -23.542 -33.765 1.00 44.92  ? 497  TRP A CZ3 1 
ATOM   1540 C  CH2 . TRP A 1 234 ? -21.818 -23.053 -34.106 1.00 43.60  ? 497  TRP A CH2 1 
ATOM   1541 N  N   . PHE A 1 235 ? -19.195 -30.883 -31.768 1.00 33.64  ? 498  PHE A N   1 
ATOM   1542 C  CA  . PHE A 1 235 ? -17.940 -31.667 -31.641 1.00 33.05  ? 498  PHE A CA  1 
ATOM   1543 C  C   . PHE A 1 235 ? -18.088 -33.118 -32.112 1.00 32.52  ? 498  PHE A C   1 
ATOM   1544 O  O   . PHE A 1 235 ? -17.246 -33.968 -31.783 1.00 35.46  ? 498  PHE A O   1 
ATOM   1545 C  CB  . PHE A 1 235 ? -17.434 -31.473 -30.223 1.00 33.50  ? 498  PHE A CB  1 
ATOM   1546 C  CG  . PHE A 1 235 ? -17.112 -30.021 -30.016 1.00 35.49  ? 498  PHE A CG  1 
ATOM   1547 C  CD1 . PHE A 1 235 ? -16.042 -29.445 -30.690 1.00 35.30  ? 498  PHE A CD1 1 
ATOM   1548 C  CD2 . PHE A 1 235 ? -17.920 -29.216 -29.227 1.00 34.11  ? 498  PHE A CD2 1 
ATOM   1549 C  CE1 . PHE A 1 235 ? -15.784 -28.090 -30.565 1.00 38.40  ? 498  PHE A CE1 1 
ATOM   1550 C  CE2 . PHE A 1 235 ? -17.645 -27.860 -29.096 1.00 34.50  ? 498  PHE A CE2 1 
ATOM   1551 C  CZ  . PHE A 1 235 ? -16.589 -27.300 -29.766 1.00 34.74  ? 498  PHE A CZ  1 
ATOM   1552 N  N   . SER A 1 236 ? -19.131 -33.390 -32.898 0.34 32.00  ? 499  SER A N   1 
ATOM   1553 C  CA  . SER A 1 236 ? -19.280 -34.626 -33.707 0.34 31.68  ? 499  SER A CA  1 
ATOM   1554 C  C   . SER A 1 236 ? -18.046 -34.786 -34.599 0.34 32.01  ? 499  SER A C   1 
ATOM   1555 O  O   . SER A 1 236 ? -17.469 -33.750 -34.970 0.34 33.33  ? 499  SER A O   1 
ATOM   1556 C  CB  . SER A 1 236 ? -20.522 -34.547 -34.540 0.34 31.25  ? 499  SER A CB  1 
ATOM   1557 O  OG  . SER A 1 236 ? -20.517 -33.351 -35.309 0.34 28.81  ? 499  SER A OG  1 
ATOM   1558 N  N   . ARG A 1 237 ? -17.670 -36.021 -34.948 1.00 31.58  ? 500  ARG A N   1 
ATOM   1559 C  CA  . ARG A 1 237 ? -16.576 -36.249 -35.909 1.00 34.86  ? 500  ARG A CA  1 
ATOM   1560 C  C   . ARG A 1 237 ? -16.927 -35.657 -37.279 1.00 37.29  ? 500  ARG A C   1 
ATOM   1561 O  O   . ARG A 1 237 ? -16.031 -34.989 -37.903 1.00 33.30  ? 500  ARG A O   1 
ATOM   1562 C  CB  . ARG A 1 237 ? -16.159 -37.715 -36.014 1.00 36.93  ? 500  ARG A CB  1 
ATOM   1563 C  CG  . ARG A 1 237 ? -14.776 -37.844 -36.631 1.00 35.20  ? 500  ARG A CG  1 
ATOM   1564 C  CD  . ARG A 1 237 ? -14.046 -39.078 -36.195 1.00 34.10  ? 500  ARG A CD  1 
ATOM   1565 N  NE  . ARG A 1 237 ? -12.677 -39.011 -36.648 1.00 30.12  ? 500  ARG A NE  1 
ATOM   1566 C  CZ  . ARG A 1 237 ? -11.680 -38.392 -36.020 1.00 30.84  ? 500  ARG A CZ  1 
ATOM   1567 N  NH1 . ARG A 1 237 ? -11.888 -37.744 -34.888 1.00 28.49  ? 500  ARG A NH1 1 
ATOM   1568 N  NH2 . ARG A 1 237 ? -10.455 -38.442 -36.539 1.00 30.34  ? 500  ARG A NH2 1 
ATOM   1569 N  N   . GLU A 1 238 ? -18.169 -35.851 -37.731 0.34 37.11  ? 501  GLU A N   1 
ATOM   1570 C  CA  . GLU A 1 238 ? -18.612 -35.340 -39.058 0.34 37.50  ? 501  GLU A CA  1 
ATOM   1571 C  C   . GLU A 1 238 ? -18.487 -33.814 -39.102 0.34 36.54  ? 501  GLU A C   1 
ATOM   1572 O  O   . GLU A 1 238 ? -18.012 -33.295 -40.123 0.34 37.11  ? 501  GLU A O   1 
ATOM   1573 C  CB  . GLU A 1 238 ? -20.050 -35.776 -39.337 0.34 39.67  ? 501  GLU A CB  1 
ATOM   1574 C  CG  . GLU A 1 238 ? -20.622 -35.201 -40.618 0.34 40.53  ? 501  GLU A CG  1 
ATOM   1575 C  CD  . GLU A 1 238 ? -22.025 -35.680 -40.950 0.34 43.57  ? 501  GLU A CD  1 
ATOM   1576 O  OE1 . GLU A 1 238 ? -22.609 -35.163 -41.921 0.34 43.88  ? 501  GLU A OE1 1 
ATOM   1577 O  OE2 . GLU A 1 238 ? -22.528 -36.572 -40.239 0.34 45.80  ? 501  GLU A OE2 1 
ATOM   1578 N  N   . ASN A 1 239 ? -18.900 -33.131 -38.035 1.00 35.73  ? 502  ASN A N   1 
ATOM   1579 C  CA  . ASN A 1 239 ? -18.863 -31.650 -38.015 1.00 37.12  ? 502  ASN A CA  1 
ATOM   1580 C  C   . ASN A 1 239 ? -17.468 -31.054 -37.736 1.00 36.88  ? 502  ASN A C   1 
ATOM   1581 O  O   . ASN A 1 239 ? -17.230 -29.979 -38.272 1.00 36.72  ? 502  ASN A O   1 
ATOM   1582 C  CB  . ASN A 1 239 ? -19.810 -31.043 -36.989 1.00 34.44  ? 502  ASN A CB  1 
ATOM   1583 C  CG  . ASN A 1 239 ? -19.995 -29.575 -37.279 1.00 35.00  ? 502  ASN A CG  1 
ATOM   1584 O  OD1 . ASN A 1 239 ? -20.279 -29.222 -38.416 1.00 37.63  ? 502  ASN A OD1 1 
ATOM   1585 N  ND2 . ASN A 1 239 ? -19.759 -28.713 -36.302 1.00 37.56  ? 502  ASN A ND2 1 
ATOM   1586 N  N   . SER A 1 240 ? -16.682 -31.598 -36.797 1.00 34.43  ? 503  SER A N   1 
ATOM   1587 C  CA  . SER A 1 240 ? -15.429 -30.986 -36.253 1.00 34.07  ? 503  SER A CA  1 
ATOM   1588 C  C   . SER A 1 240 ? -14.152 -31.669 -36.774 1.00 31.66  ? 503  SER A C   1 
ATOM   1589 O  O   . SER A 1 240 ? -13.102 -31.091 -36.534 1.00 32.76  ? 503  SER A O   1 
ATOM   1590 C  CB  . SER A 1 240 ? -15.421 -30.976 -34.740 1.00 34.62  ? 503  SER A CB  1 
ATOM   1591 O  OG  . SER A 1 240 ? -15.322 -32.309 -34.199 1.00 35.93  ? 503  SER A OG  1 
ATOM   1592 N  N   . LEU A 1 241 ? -14.243 -32.868 -37.357 1.00 34.32  ? 504  LEU A N   1 
ATOM   1593 C  CA  . LEU A 1 241 ? -13.158 -33.697 -37.971 1.00 34.01  ? 504  LEU A CA  1 
ATOM   1594 C  C   . LEU A 1 241 ? -12.195 -34.305 -36.928 1.00 35.55  ? 504  LEU A C   1 
ATOM   1595 O  O   . LEU A 1 241 ? -11.693 -35.431 -37.189 1.00 34.90  ? 504  LEU A O   1 
ATOM   1596 C  CB  . LEU A 1 241 ? -12.397 -32.854 -38.993 1.00 40.13  ? 504  LEU A CB  1 
ATOM   1597 C  CG  . LEU A 1 241 ? -13.214 -32.229 -40.125 1.00 43.90  ? 504  LEU A CG  1 
ATOM   1598 C  CD1 . LEU A 1 241 ? -12.287 -31.563 -41.130 1.00 42.07  ? 504  LEU A CD1 1 
ATOM   1599 C  CD2 . LEU A 1 241 ? -14.071 -33.251 -40.838 1.00 47.49  ? 504  LEU A CD2 1 
ATOM   1600 N  N   . SER A 1 242 ? -11.927 -33.616 -35.811 1.00 30.79  ? 505  SER A N   1 
ATOM   1601 C  CA  . SER A 1 242 ? -11.064 -34.100 -34.703 1.00 32.16  ? 505  SER A CA  1 
ATOM   1602 C  C   . SER A 1 242 ? -11.900 -34.724 -33.600 1.00 30.20  ? 505  SER A C   1 
ATOM   1603 O  O   . SER A 1 242 ? -11.375 -35.550 -32.848 1.00 27.06  ? 505  SER A O   1 
ATOM   1604 C  CB  . SER A 1 242 ? -10.223 -32.983 -34.107 1.00 30.69  ? 505  SER A CB  1 
ATOM   1605 O  OG  . SER A 1 242 ? -9.409  -32.417 -35.091 1.00 33.73  ? 505  SER A OG  1 
ATOM   1606 N  N   . GLY A 1 243 ? -13.122 -34.238 -33.439 1.00 30.21  ? 506  GLY A N   1 
ATOM   1607 C  CA  . GLY A 1 243 ? -13.985 -34.578 -32.300 1.00 30.19  ? 506  GLY A CA  1 
ATOM   1608 C  C   . GLY A 1 243 ? -14.513 -35.990 -32.385 1.00 29.43  ? 506  GLY A C   1 
ATOM   1609 O  O   . GLY A 1 243 ? -14.486 -36.592 -33.468 1.00 30.05  ? 506  GLY A O   1 
ATOM   1610 N  N   . VAL A 1 244 ? -15.001 -36.484 -31.259 1.00 28.97  ? 507  VAL A N   1 
ATOM   1611 C  CA  . VAL A 1 244 ? -15.677 -37.806 -31.170 1.00 33.94  ? 507  VAL A CA  1 
ATOM   1612 C  C   . VAL A 1 244 ? -16.977 -37.687 -30.333 1.00 31.88  ? 507  VAL A C   1 
ATOM   1613 O  O   . VAL A 1 244 ? -17.429 -38.714 -29.781 1.00 30.48  ? 507  VAL A O   1 
ATOM   1614 C  CB  . VAL A 1 244 ? -14.707 -38.845 -30.570 1.00 31.54  ? 507  VAL A CB  1 
ATOM   1615 C  CG1 . VAL A 1 244 ? -13.467 -39.027 -31.426 1.00 32.62  ? 507  VAL A CG1 1 
ATOM   1616 C  CG2 . VAL A 1 244 ? -14.301 -38.476 -29.151 1.00 32.91  ? 507  VAL A CG2 1 
ATOM   1617 N  N   . GLU A 1 245 ? -17.547 -36.500 -30.168 1.00 31.27  ? 508  GLU A N   1 
ATOM   1618 C  CA  . GLU A 1 245 ? -18.769 -36.361 -29.315 1.00 37.19  ? 508  GLU A CA  1 
ATOM   1619 C  C   . GLU A 1 245 ? -19.873 -37.270 -29.895 1.00 34.31  ? 508  GLU A C   1 
ATOM   1620 O  O   . GLU A 1 245 ? -20.117 -37.263 -31.139 1.00 31.88  ? 508  GLU A O   1 
ATOM   1621 C  CB  . GLU A 1 245 ? -19.234 -34.917 -29.152 1.00 38.20  ? 508  GLU A CB  1 
ATOM   1622 C  CG  . GLU A 1 245 ? -20.343 -34.764 -28.104 1.00 45.39  ? 508  GLU A CG  1 
ATOM   1623 C  CD  . GLU A 1 245 ? -21.763 -35.107 -28.565 1.00 51.54  ? 508  GLU A CD  1 
ATOM   1624 O  OE1 . GLU A 1 245 ? -22.073 -34.886 -29.766 1.00 57.18  ? 508  GLU A OE1 1 
ATOM   1625 O  OE2 . GLU A 1 245 ? -22.570 -35.623 -27.729 1.00 61.56  ? 508  GLU A OE2 1 
ATOM   1626 N  N   . GLY A 1 246 ? -20.506 -38.060 -29.025 0.34 35.93  ? 509  GLY A N   1 
ATOM   1627 C  CA  . GLY A 1 246 ? -21.607 -38.976 -29.384 0.34 36.86  ? 509  GLY A CA  1 
ATOM   1628 C  C   . GLY A 1 246 ? -21.146 -40.111 -30.285 0.34 37.52  ? 509  GLY A C   1 
ATOM   1629 O  O   . GLY A 1 246 ? -22.007 -40.718 -30.948 0.34 37.91  ? 509  GLY A O   1 
ATOM   1630 N  N   . GLU A 1 247 ? -19.844 -40.409 -30.319 0.34 37.25  ? 510  GLU A N   1 
ATOM   1631 C  CA  . GLU A 1 247 ? -19.319 -41.547 -31.119 0.34 38.43  ? 510  GLU A CA  1 
ATOM   1632 C  C   . GLU A 1 247 ? -19.725 -42.852 -30.432 0.34 38.71  ? 510  GLU A C   1 
ATOM   1633 O  O   . GLU A 1 247 ? -20.515 -43.615 -31.024 0.34 41.38  ? 510  GLU A O   1 
ATOM   1634 C  CB  . GLU A 1 247 ? -17.803 -41.469 -31.303 0.34 37.76  ? 510  GLU A CB  1 
ATOM   1635 C  CG  . GLU A 1 247 ? -17.413 -40.720 -32.558 0.34 38.36  ? 510  GLU A CG  1 
ATOM   1636 C  CD  . GLU A 1 247 ? -18.032 -41.297 -33.820 0.34 37.44  ? 510  GLU A CD  1 
ATOM   1637 O  OE1 . GLU A 1 247 ? -18.657 -42.368 -33.729 0.34 37.49  ? 510  GLU A OE1 1 
ATOM   1638 O  OE2 . GLU A 1 247 ? -17.888 -40.676 -34.886 0.34 38.63  ? 510  GLU A OE2 1 
ATOM   1639 N  N   . GLY A 1 248 ? -19.221 -43.087 -29.222 0.34 37.07  ? 511  GLY A N   1 
ATOM   1640 C  CA  . GLY A 1 248 ? -19.408 -44.369 -28.517 0.34 37.34  ? 511  GLY A CA  1 
ATOM   1641 C  C   . GLY A 1 248 ? -18.135 -45.205 -28.511 0.34 37.74  ? 511  GLY A C   1 
ATOM   1642 O  O   . GLY A 1 248 ? -17.386 -45.175 -29.509 0.34 37.74  ? 511  GLY A O   1 
ATOM   1643 N  N   A LEU A 1 249 ? -17.919 -45.955 -27.432 0.17 36.55  ? 512  LEU A N   1 
ATOM   1644 N  N   B LEU A 1 249 ? -17.879 -45.917 -27.399 0.17 36.89  ? 512  LEU A N   1 
ATOM   1645 C  CA  A LEU A 1 249 ? -16.670 -46.707 -27.149 0.17 36.82  ? 512  LEU A CA  1 
ATOM   1646 C  CA  B LEU A 1 249 ? -16.653 -46.728 -27.157 0.17 37.21  ? 512  LEU A CA  1 
ATOM   1647 C  C   A LEU A 1 249 ? -16.445 -47.797 -28.207 0.17 36.02  ? 512  LEU A C   1 
ATOM   1648 C  C   B LEU A 1 249 ? -16.429 -47.715 -28.305 0.17 36.33  ? 512  LEU A C   1 
ATOM   1649 O  O   A LEU A 1 249 ? -15.289 -48.226 -28.358 0.17 35.66  ? 512  LEU A O   1 
ATOM   1650 O  O   B LEU A 1 249 ? -15.259 -47.994 -28.612 0.17 36.13  ? 512  LEU A O   1 
ATOM   1651 C  CB  A LEU A 1 249 ? -16.796 -47.297 -25.743 0.17 36.70  ? 512  LEU A CB  1 
ATOM   1652 C  CB  B LEU A 1 249 ? -16.798 -47.484 -25.834 0.17 37.37  ? 512  LEU A CB  1 
ATOM   1653 C  CG  A LEU A 1 249 ? -15.498 -47.788 -25.112 0.17 36.49  ? 512  LEU A CG  1 
ATOM   1654 C  CG  B LEU A 1 249 ? -15.891 -47.008 -24.705 0.17 37.04  ? 512  LEU A CG  1 
ATOM   1655 C  CD1 A LEU A 1 249 ? -14.509 -46.645 -24.936 0.17 36.67  ? 512  LEU A CD1 1 
ATOM   1656 C  CD1 B LEU A 1 249 ? -15.973 -47.955 -23.520 0.17 36.79  ? 512  LEU A CD1 1 
ATOM   1657 C  CD2 A LEU A 1 249 ? -15.782 -48.466 -23.783 0.17 36.10  ? 512  LEU A CD2 1 
ATOM   1658 C  CD2 B LEU A 1 249 ? -14.455 -46.875 -25.190 0.17 37.18  ? 512  LEU A CD2 1 
ATOM   1659 N  N   . HIS A 1 250 ? -17.506 -48.240 -28.890 1.00 36.38  ? 513  HIS A N   1 
ATOM   1660 C  CA  . HIS A 1 250 ? -17.433 -49.215 -30.011 1.00 35.04  ? 513  HIS A CA  1 
ATOM   1661 C  C   . HIS A 1 250 ? -17.041 -48.585 -31.356 1.00 36.55  ? 513  HIS A C   1 
ATOM   1662 O  O   . HIS A 1 250 ? -16.914 -49.324 -32.348 1.00 35.40  ? 513  HIS A O   1 
ATOM   1663 C  CB  . HIS A 1 250 ? -18.791 -49.933 -30.178 1.00 40.31  ? 513  HIS A CB  1 
ATOM   1664 C  CG  . HIS A 1 250 ? -19.929 -48.993 -30.401 1.00 37.85  ? 513  HIS A CG  1 
ATOM   1665 N  ND1 . HIS A 1 250 ? -20.385 -48.175 -29.406 1.00 39.95  ? 513  HIS A ND1 1 
ATOM   1666 C  CD2 . HIS A 1 250 ? -20.676 -48.722 -31.500 1.00 39.06  ? 513  HIS A CD2 1 
ATOM   1667 C  CE1 . HIS A 1 250 ? -21.364 -47.420 -29.878 1.00 40.19  ? 513  HIS A CE1 1 
ATOM   1668 N  NE2 . HIS A 1 250 ? -21.578 -47.758 -31.161 1.00 39.45  ? 513  HIS A NE2 1 
ATOM   1669 N  N   . LYS A 1 251 ? -16.862 -47.260 -31.400 0.34 36.50  ? 514  LYS A N   1 
ATOM   1670 C  CA  . LYS A 1 251 ? -16.434 -46.536 -32.628 0.34 37.23  ? 514  LYS A CA  1 
ATOM   1671 C  C   . LYS A 1 251 ? -15.023 -45.953 -32.452 0.34 35.66  ? 514  LYS A C   1 
ATOM   1672 O  O   . LYS A 1 251 ? -14.341 -45.798 -33.478 0.34 34.95  ? 514  LYS A O   1 
ATOM   1673 C  CB  . LYS A 1 251 ? -17.473 -45.473 -32.996 0.34 39.25  ? 514  LYS A CB  1 
ATOM   1674 C  CG  . LYS A 1 251 ? -18.915 -45.962 -32.920 0.34 40.98  ? 514  LYS A CG  1 
ATOM   1675 C  CD  . LYS A 1 251 ? -19.674 -45.863 -34.220 0.34 42.69  ? 514  LYS A CD  1 
ATOM   1676 C  CE  . LYS A 1 251 ? -20.035 -44.444 -34.598 0.34 44.55  ? 514  LYS A CE  1 
ATOM   1677 N  NZ  . LYS A 1 251 ? -20.748 -44.400 -35.897 0.34 45.66  ? 514  LYS A NZ  1 
ATOM   1678 N  N   . LEU A 1 252 ? -14.598 -45.658 -31.217 1.00 33.92  ? 515  LEU A N   1 
ATOM   1679 C  CA  . LEU A 1 252 ? -13.293 -44.975 -30.950 1.00 34.44  ? 515  LEU A CA  1 
ATOM   1680 C  C   . LEU A 1 252 ? -12.110 -45.752 -31.534 1.00 30.74  ? 515  LEU A C   1 
ATOM   1681 O  O   . LEU A 1 252 ? -11.254 -45.122 -32.158 1.00 33.19  ? 515  LEU A O   1 
ATOM   1682 C  CB  . LEU A 1 252 ? -13.095 -44.766 -29.451 1.00 31.14  ? 515  LEU A CB  1 
ATOM   1683 C  CG  . LEU A 1 252 ? -14.137 -43.888 -28.774 1.00 33.30  ? 515  LEU A CG  1 
ATOM   1684 C  CD1 . LEU A 1 252 ? -13.722 -43.551 -27.354 1.00 35.33  ? 515  LEU A CD1 1 
ATOM   1685 C  CD2 . LEU A 1 252 ? -14.400 -42.613 -29.553 1.00 33.39  ? 515  LEU A CD2 1 
ATOM   1686 N  N   . GLY A 1 253 ? -12.076 -47.071 -31.357 1.00 30.91  ? 516  GLY A N   1 
ATOM   1687 C  CA  . GLY A 1 253 ? -11.029 -47.942 -31.917 1.00 30.11  ? 516  GLY A CA  1 
ATOM   1688 C  C   . GLY A 1 253 ? -10.972 -47.858 -33.433 1.00 31.67  ? 516  GLY A C   1 
ATOM   1689 O  O   . GLY A 1 253 ? -9.847  -47.734 -34.011 1.00 33.43  ? 516  GLY A O   1 
ATOM   1690 N  N   . TYR A 1 254 ? -12.130 -47.874 -34.083 1.00 29.22  ? 517  TYR A N   1 
ATOM   1691 C  CA  . TYR A 1 254 ? -12.192 -47.754 -35.557 1.00 30.06  ? 517  TYR A CA  1 
ATOM   1692 C  C   . TYR A 1 254 ? -11.673 -46.369 -35.967 1.00 30.15  ? 517  TYR A C   1 
ATOM   1693 O  O   . TYR A 1 254 ? -10.959 -46.245 -37.003 1.00 30.01  ? 517  TYR A O   1 
ATOM   1694 C  CB  . TYR A 1 254 ? -13.599 -48.002 -36.082 1.00 30.95  ? 517  TYR A CB  1 
ATOM   1695 C  CG  . TYR A 1 254 ? -14.049 -49.441 -36.085 1.00 29.88  ? 517  TYR A CG  1 
ATOM   1696 C  CD1 . TYR A 1 254 ? -13.498 -50.371 -36.967 1.00 31.30  ? 517  TYR A CD1 1 
ATOM   1697 C  CD2 . TYR A 1 254 ? -15.054 -49.866 -35.238 1.00 30.08  ? 517  TYR A CD2 1 
ATOM   1698 C  CE1 . TYR A 1 254 ? -13.939 -51.688 -37.014 1.00 29.74  ? 517  TYR A CE1 1 
ATOM   1699 C  CE2 . TYR A 1 254 ? -15.517 -51.174 -35.276 1.00 31.94  ? 517  TYR A CE2 1 
ATOM   1700 C  CZ  . TYR A 1 254 ? -14.967 -52.083 -36.171 1.00 32.51  ? 517  TYR A CZ  1 
ATOM   1701 O  OH  . TYR A 1 254 ? -15.428 -53.374 -36.178 1.00 33.46  ? 517  TYR A OH  1 
ATOM   1702 N  N   . ILE A 1 255 ? -11.975 -45.358 -35.168 1.00 28.07  ? 518  ILE A N   1 
ATOM   1703 C  CA  . ILE A 1 255 ? -11.552 -43.972 -35.466 1.00 31.43  ? 518  ILE A CA  1 
ATOM   1704 C  C   . ILE A 1 255 ? -10.011 -43.884 -35.395 1.00 33.03  ? 518  ILE A C   1 
ATOM   1705 O  O   . ILE A 1 255 ? -9.412  -43.358 -36.350 1.00 34.55  ? 518  ILE A O   1 
ATOM   1706 C  CB  . ILE A 1 255 ? -12.317 -42.962 -34.587 1.00 32.55  ? 518  ILE A CB  1 
ATOM   1707 C  CG1 . ILE A 1 255 ? -13.778 -42.885 -35.067 1.00 33.82  ? 518  ILE A CG1 1 
ATOM   1708 C  CG2 . ILE A 1 255 ? -11.616 -41.596 -34.575 1.00 29.57  ? 518  ILE A CG2 1 
ATOM   1709 C  CD1 . ILE A 1 255 ? -14.754 -42.193 -34.119 1.00 34.23  ? 518  ILE A CD1 1 
ATOM   1710 N  N   . LEU A 1 256 ? -9.403  -44.406 -34.324 0.34 33.37  ? 519  LEU A N   1 
ATOM   1711 C  CA  . LEU A 1 256 ? -7.928  -44.416 -34.120 0.34 34.40  ? 519  LEU A CA  1 
ATOM   1712 C  C   . LEU A 1 256 ? -7.245  -45.212 -35.240 0.34 35.19  ? 519  LEU A C   1 
ATOM   1713 O  O   . LEU A 1 256 ? -6.134  -44.811 -35.642 0.34 35.36  ? 519  LEU A O   1 
ATOM   1714 C  CB  . LEU A 1 256 ? -7.598  -45.015 -32.750 0.34 34.59  ? 519  LEU A CB  1 
ATOM   1715 C  CG  . LEU A 1 256 ? -8.032  -44.186 -31.543 0.34 34.74  ? 519  LEU A CG  1 
ATOM   1716 C  CD1 . LEU A 1 256 ? -7.543  -44.820 -30.250 0.34 34.48  ? 519  LEU A CD1 1 
ATOM   1717 C  CD2 . LEU A 1 256 ? -7.536  -42.753 -31.656 0.34 35.44  ? 519  LEU A CD2 1 
ATOM   1718 N  N   . ARG A 1 257 ? -7.869  -46.301 -35.710 1.00 35.52  ? 520  ARG A N   1 
ATOM   1719 C  CA  . ARG A 1 257 ? -7.323  -47.111 -36.833 1.00 36.80  ? 520  ARG A CA  1 
ATOM   1720 C  C   . ARG A 1 257 ? -7.404  -46.287 -38.124 1.00 39.84  ? 520  ARG A C   1 
ATOM   1721 O  O   . ARG A 1 257 ? -6.450  -46.393 -38.949 1.00 34.36  ? 520  ARG A O   1 
ATOM   1722 C  CB  . ARG A 1 257 ? -8.015  -48.464 -36.983 1.00 37.21  ? 520  ARG A CB  1 
ATOM   1723 C  CG  . ARG A 1 257 ? -7.409  -49.339 -38.074 1.00 37.21  ? 520  ARG A CG  1 
ATOM   1724 C  CD  . ARG A 1 257 ? -8.144  -50.654 -38.284 1.00 37.19  ? 520  ARG A CD  1 
ATOM   1725 N  NE  . ARG A 1 257 ? -9.465  -50.460 -38.902 1.00 39.05  ? 520  ARG A NE  1 
ATOM   1726 C  CZ  . ARG A 1 257 ? -10.278 -51.432 -39.278 1.00 35.44  ? 520  ARG A CZ  1 
ATOM   1727 N  NH1 . ARG A 1 257 ? -9.941  -52.694 -39.099 1.00 38.52  ? 520  ARG A NH1 1 
ATOM   1728 N  NH2 . ARG A 1 257 ? -11.429 -51.136 -39.844 1.00 44.57  ? 520  ARG A NH2 1 
ATOM   1729 N  N   . ASP A 1 258 ? -8.430  -45.440 -38.277 1.00 37.09  ? 521  ASP A N   1 
ATOM   1730 C  CA  . ASP A 1 258 ? -8.552  -44.596 -39.506 1.00 38.80  ? 521  ASP A CA  1 
ATOM   1731 C  C   . ASP A 1 258 ? -7.423  -43.547 -39.502 1.00 37.87  ? 521  ASP A C   1 
ATOM   1732 O  O   . ASP A 1 258 ? -6.786  -43.372 -40.531 1.00 39.46  ? 521  ASP A O   1 
ATOM   1733 C  CB  . ASP A 1 258 ? -9.952  -44.007 -39.710 1.00 39.09  ? 521  ASP A CB  1 
ATOM   1734 C  CG  . ASP A 1 258 ? -10.982 -44.919 -40.410 1.00 41.89  ? 521  ASP A CG  1 
ATOM   1735 O  OD1 . ASP A 1 258 ? -10.616 -45.984 -40.931 1.00 38.04  ? 521  ASP A OD1 1 
ATOM   1736 O  OD2 . ASP A 1 258 ? -12.183 -44.569 -40.375 1.00 41.08  ? 521  ASP A OD2 1 
ATOM   1737 N  N   . VAL A 1 259 ? -7.179  -42.882 -38.380 1.00 33.55  ? 522  VAL A N   1 
ATOM   1738 C  CA  . VAL A 1 259 ? -6.047  -41.936 -38.217 1.00 36.25  ? 522  VAL A CA  1 
ATOM   1739 C  C   . VAL A 1 259 ? -4.735  -42.658 -38.569 1.00 37.30  ? 522  VAL A C   1 
ATOM   1740 O  O   . VAL A 1 259 ? -3.964  -42.083 -39.294 1.00 40.04  ? 522  VAL A O   1 
ATOM   1741 C  CB  . VAL A 1 259 ? -6.004  -41.385 -36.787 1.00 36.04  ? 522  VAL A CB  1 
ATOM   1742 C  CG1 . VAL A 1 259 ? -4.759  -40.536 -36.588 1.00 36.75  ? 522  VAL A CG1 1 
ATOM   1743 C  CG2 . VAL A 1 259 ? -7.276  -40.609 -36.451 1.00 35.87  ? 522  VAL A CG2 1 
ATOM   1744 N  N   . SER A 1 260 ? -4.528  -43.892 -38.105 1.00 35.53  ? 523  SER A N   1 
ATOM   1745 C  CA  . SER A 1 260 ? -3.289  -44.686 -38.325 1.00 37.62  ? 523  SER A CA  1 
ATOM   1746 C  C   . SER A 1 260 ? -3.047  -44.866 -39.828 1.00 38.13  ? 523  SER A C   1 
ATOM   1747 O  O   . SER A 1 260 ? -1.897  -44.911 -40.205 1.00 37.57  ? 523  SER A O   1 
ATOM   1748 C  CB  . SER A 1 260 ? -3.320  -46.009 -37.613 1.00 35.55  ? 523  SER A CB  1 
ATOM   1749 O  OG  . SER A 1 260 ? -3.990  -46.979 -38.408 1.00 39.95  ? 523  SER A OG  1 
ATOM   1750 N  N   . LYS A 1 261 ? -4.099  -44.894 -40.640 1.00 37.42  ? 524  LYS A N   1 
ATOM   1751 C  CA  . LYS A 1 261 ? -4.054  -45.140 -42.111 1.00 42.24  ? 524  LYS A CA  1 
ATOM   1752 C  C   . LYS A 1 261 ? -3.400  -43.967 -42.850 1.00 41.18  ? 524  LYS A C   1 
ATOM   1753 O  O   . LYS A 1 261 ? -2.953  -44.184 -43.997 1.00 44.23  ? 524  LYS A O   1 
ATOM   1754 C  CB  . LYS A 1 261 ? -5.465  -45.328 -42.673 1.00 41.55  ? 524  LYS A CB  1 
ATOM   1755 C  CG  . LYS A 1 261 ? -5.984  -46.749 -42.549 1.00 56.75  ? 524  LYS A CG  1 
ATOM   1756 C  CD  . LYS A 1 261 ? -7.471  -46.848 -42.801 1.00 63.00  ? 524  LYS A CD  1 
ATOM   1757 C  CE  . LYS A 1 261 ? -7.959  -48.273 -42.806 1.00 72.28  ? 524  LYS A CE  1 
ATOM   1758 N  NZ  . LYS A 1 261 ? -9.393  -48.303 -43.175 1.00 92.48  ? 524  LYS A NZ  1 
ATOM   1759 N  N   . LYS A 1 262 ? -3.427  -42.776 -42.256 1.00 39.05  ? 525  LYS A N   1 
ATOM   1760 C  CA  . LYS A 1 262 ? -2.808  -41.559 -42.828 1.00 46.65  ? 525  LYS A CA  1 
ATOM   1761 C  C   . LYS A 1 262 ? -1.292  -41.702 -42.810 1.00 47.23  ? 525  LYS A C   1 
ATOM   1762 O  O   . LYS A 1 262 ? -0.739  -42.281 -41.860 1.00 48.49  ? 525  LYS A O   1 
ATOM   1763 C  CB  . LYS A 1 262 ? -3.189  -40.303 -42.038 1.00 47.22  ? 525  LYS A CB  1 
ATOM   1764 C  CG  . LYS A 1 262 ? -4.690  -40.065 -41.958 1.00 49.03  ? 525  LYS A CG  1 
ATOM   1765 C  CD  . LYS A 1 262 ? -5.088  -38.628 -41.889 1.00 50.66  ? 525  LYS A CD  1 
ATOM   1766 C  CE  . LYS A 1 262 ? -6.410  -38.345 -42.571 1.00 61.16  ? 525  LYS A CE  1 
ATOM   1767 N  NZ  . LYS A 1 262 ? -6.357  -37.071 -43.332 1.00 69.29  ? 525  LYS A NZ  1 
ATOM   1768 N  N   . GLU A 1 263 ? -0.631  -41.184 -43.845 0.34 47.40  ? 526  GLU A N   1 
ATOM   1769 C  CA  . GLU A 1 263 ? 0.849   -41.092 -43.905 0.34 47.34  ? 526  GLU A CA  1 
ATOM   1770 C  C   . GLU A 1 263 ? 1.294   -40.069 -42.858 0.34 45.65  ? 526  GLU A C   1 
ATOM   1771 O  O   . GLU A 1 263 ? 0.659   -39.003 -42.778 0.34 45.77  ? 526  GLU A O   1 
ATOM   1772 C  CB  . GLU A 1 263 ? 1.305   -40.721 -45.317 0.34 49.74  ? 526  GLU A CB  1 
ATOM   1773 C  CG  . GLU A 1 263 ? 1.022   -41.809 -46.342 0.34 50.90  ? 526  GLU A CG  1 
ATOM   1774 C  CD  . GLU A 1 263 ? 1.527   -43.192 -45.955 0.34 51.54  ? 526  GLU A CD  1 
ATOM   1775 O  OE1 . GLU A 1 263 ? 2.634   -43.280 -45.380 0.34 51.83  ? 526  GLU A OE1 1 
ATOM   1776 O  OE2 . GLU A 1 263 ? 0.808   -44.181 -46.222 0.34 50.88  ? 526  GLU A OE2 1 
ATOM   1777 N  N   . GLY A 1 264 ? 2.315   -40.408 -42.068 1.00 44.44  ? 527  GLY A N   1 
ATOM   1778 C  CA  . GLY A 1 264 ? 2.837   -39.525 -41.010 1.00 43.56  ? 527  GLY A CA  1 
ATOM   1779 C  C   . GLY A 1 264 ? 3.848   -40.226 -40.128 1.00 43.88  ? 527  GLY A C   1 
ATOM   1780 O  O   . GLY A 1 264 ? 4.264   -41.350 -40.452 1.00 46.92  ? 527  GLY A O   1 
ATOM   1781 N  N   . GLY A 1 265 ? 4.203   -39.605 -39.011 1.00 46.83  ? 528  GLY A N   1 
ATOM   1782 C  CA  . GLY A 1 265 ? 5.108   -40.211 -38.016 1.00 49.36  ? 528  GLY A CA  1 
ATOM   1783 C  C   . GLY A 1 265 ? 4.322   -40.980 -36.966 1.00 49.22  ? 528  GLY A C   1 
ATOM   1784 O  O   . GLY A 1 265 ? 3.256   -41.526 -37.299 1.00 44.92  ? 528  GLY A O   1 
ATOM   1785 N  N   . ALA A 1 266 ? 4.827   -41.016 -35.736 1.00 41.33  ? 529  ALA A N   1 
ATOM   1786 C  CA  . ALA A 1 266 ? 4.256   -41.807 -34.627 1.00 40.27  ? 529  ALA A CA  1 
ATOM   1787 C  C   . ALA A 1 266 ? 2.872   -41.241 -34.283 1.00 38.09  ? 529  ALA A C   1 
ATOM   1788 O  O   . ALA A 1 266 ? 2.536   -40.166 -34.796 1.00 37.02  ? 529  ALA A O   1 
ATOM   1789 C  CB  . ALA A 1 266 ? 5.205   -41.761 -33.449 1.00 39.17  ? 529  ALA A CB  1 
ATOM   1790 N  N   . MET A 1 267 ? 2.123   -41.908 -33.409 1.00 34.60  ? 530  MET A N   1 
ATOM   1791 C  CA  . MET A 1 267 ? 0.890   -41.352 -32.805 1.00 36.35  ? 530  MET A CA  1 
ATOM   1792 C  C   . MET A 1 267 ? 1.275   -40.831 -31.418 1.00 32.66  ? 530  MET A C   1 
ATOM   1793 O  O   . MET A 1 267 ? 1.931   -41.551 -30.641 1.00 36.60  ? 530  MET A O   1 
ATOM   1794 C  CB  . MET A 1 267 ? -0.249  -42.388 -32.756 1.00 38.46  ? 530  MET A CB  1 
ATOM   1795 C  CG  . MET A 1 267 ? -0.687  -42.838 -34.160 1.00 41.79  ? 530  MET A CG  1 
ATOM   1796 S  SD  . MET A 1 267 ? -2.089  -44.000 -34.310 1.00 46.31  ? 530  MET A SD  1 
ATOM   1797 C  CE  . MET A 1 267 ? -3.474  -43.047 -33.721 1.00 45.92  ? 530  MET A CE  1 
ATOM   1798 N  N   . TYR A 1 268 ? 0.914   -39.592 -31.141 1.00 31.49  ? 531  TYR A N   1 
ATOM   1799 C  CA  . TYR A 1 268 ? 1.268   -38.876 -29.903 1.00 31.01  ? 531  TYR A CA  1 
ATOM   1800 C  C   . TYR A 1 268 ? 0.002   -38.766 -29.091 1.00 32.81  ? 531  TYR A C   1 
ATOM   1801 O  O   . TYR A 1 268 ? -1.077  -38.450 -29.666 1.00 34.49  ? 531  TYR A O   1 
ATOM   1802 C  CB  . TYR A 1 268 ? 1.907   -37.529 -30.233 1.00 32.82  ? 531  TYR A CB  1 
ATOM   1803 C  CG  . TYR A 1 268 ? 3.227   -37.689 -30.938 1.00 33.08  ? 531  TYR A CG  1 
ATOM   1804 C  CD1 . TYR A 1 268 ? 3.285   -37.855 -32.304 1.00 33.24  ? 531  TYR A CD1 1 
ATOM   1805 C  CD2 . TYR A 1 268 ? 4.395   -37.823 -30.214 1.00 31.12  ? 531  TYR A CD2 1 
ATOM   1806 C  CE1 . TYR A 1 268 ? 4.498   -38.059 -32.938 1.00 37.30  ? 531  TYR A CE1 1 
ATOM   1807 C  CE2 . TYR A 1 268 ? 5.608   -38.038 -30.829 1.00 33.89  ? 531  TYR A CE2 1 
ATOM   1808 C  CZ  . TYR A 1 268 ? 5.665   -38.153 -32.198 1.00 36.75  ? 531  TYR A CZ  1 
ATOM   1809 O  OH  . TYR A 1 268 ? 6.874   -38.378 -32.795 1.00 35.70  ? 531  TYR A OH  1 
ATOM   1810 N  N   . ALA A 1 269 ? 0.137   -39.030 -27.801 1.00 31.57  ? 532  ALA A N   1 
ATOM   1811 C  CA  . ALA A 1 269 ? -0.991  -38.972 -26.871 1.00 34.53  ? 532  ALA A CA  1 
ATOM   1812 C  C   . ALA A 1 269 ? -0.478  -38.425 -25.557 1.00 32.26  ? 532  ALA A C   1 
ATOM   1813 O  O   . ALA A 1 269 ? -0.570  -39.122 -24.569 1.00 35.86  ? 532  ALA A O   1 
ATOM   1814 C  CB  . ALA A 1 269 ? -1.630  -40.340 -26.741 1.00 34.53  ? 532  ALA A CB  1 
ATOM   1815 N  N   . ASP A 1 270 ? -0.089  -37.165 -25.550 1.00 32.03  ? 533  ASP A N   1 
ATOM   1816 C  CA  . ASP A 1 270 ? 0.393   -36.480 -24.334 1.00 34.40  ? 533  ASP A CA  1 
ATOM   1817 C  C   . ASP A 1 270 ? -0.791  -35.974 -23.526 1.00 39.69  ? 533  ASP A C   1 
ATOM   1818 O  O   . ASP A 1 270 ? -1.575  -35.200 -24.051 1.00 38.53  ? 533  ASP A O   1 
ATOM   1819 C  CB  . ASP A 1 270 ? 1.311   -35.321 -24.722 1.00 34.79  ? 533  ASP A CB  1 
ATOM   1820 C  CG  . ASP A 1 270 ? 2.545   -35.796 -25.460 1.00 37.67  ? 533  ASP A CG  1 
ATOM   1821 O  OD1 . ASP A 1 270 ? 2.856   -37.024 -25.341 1.00 38.95  ? 533  ASP A OD1 1 
ATOM   1822 O  OD2 . ASP A 1 270 ? 3.168   -34.967 -26.172 1.00 37.70  ? 533  ASP A OD2 1 
ATOM   1823 N  N   . ASP A 1 271 ? -0.902  -36.423 -22.271 0.34 40.29  ? 534  ASP A N   1 
ATOM   1824 C  CA  . ASP A 1 271 ? -1.862  -35.898 -21.263 0.34 41.09  ? 534  ASP A CA  1 
ATOM   1825 C  C   . ASP A 1 271 ? -1.346  -34.553 -20.743 0.34 40.82  ? 534  ASP A C   1 
ATOM   1826 O  O   . ASP A 1 271 ? -0.117  -34.407 -20.612 0.34 41.80  ? 534  ASP A O   1 
ATOM   1827 C  CB  . ASP A 1 271 ? -2.058  -36.881 -20.106 0.34 42.99  ? 534  ASP A CB  1 
ATOM   1828 C  CG  . ASP A 1 271 ? -3.218  -37.839 -20.313 0.34 44.85  ? 534  ASP A CG  1 
ATOM   1829 O  OD1 . ASP A 1 271 ? -3.886  -37.720 -21.359 0.34 45.94  ? 534  ASP A OD1 1 
ATOM   1830 O  OD2 . ASP A 1 271 ? -3.453  -38.686 -19.422 0.34 46.45  ? 534  ASP A OD2 1 
ATOM   1831 N  N   . THR A 1 272 ? -2.252  -33.612 -20.460 1.00 40.29  ? 535  THR A N   1 
ATOM   1832 C  CA  . THR A 1 272 ? -1.901  -32.310 -19.848 1.00 36.97  ? 535  THR A CA  1 
ATOM   1833 C  C   . THR A 1 272 ? -2.011  -32.514 -18.358 1.00 38.31  ? 535  THR A C   1 
ATOM   1834 O  O   . THR A 1 272 ? -2.894  -33.233 -17.916 1.00 42.24  ? 535  THR A O   1 
ATOM   1835 C  CB  . THR A 1 272 ? -2.783  -31.168 -20.346 1.00 37.87  ? 535  THR A CB  1 
ATOM   1836 O  OG1 . THR A 1 272 ? -2.454  -30.960 -21.715 1.00 38.36  ? 535  THR A OG1 1 
ATOM   1837 C  CG2 . THR A 1 272 ? -2.578  -29.860 -19.619 1.00 40.67  ? 535  THR A CG2 1 
ATOM   1838 N  N   . ALA A 1 273 ? -1.099  -31.893 -17.608 0.34 39.58  ? 536  ALA A N   1 
ATOM   1839 C  CA  . ALA A 1 273 ? -1.163  -31.755 -16.135 0.34 39.14  ? 536  ALA A CA  1 
ATOM   1840 C  C   . ALA A 1 273 ? -2.198  -30.677 -15.792 0.34 37.87  ? 536  ALA A C   1 
ATOM   1841 O  O   . ALA A 1 273 ? -2.035  -29.536 -16.266 0.34 38.77  ? 536  ALA A O   1 
ATOM   1842 C  CB  . ALA A 1 273 ? 0.205   -31.417 -15.591 0.34 38.60  ? 536  ALA A CB  1 
ATOM   1843 N  N   . GLY A 1 274 ? -3.233  -31.044 -15.031 0.34 37.20  ? 537  GLY A N   1 
ATOM   1844 C  CA  . GLY A 1 274 ? -4.338  -30.153 -14.625 0.34 37.16  ? 537  GLY A CA  1 
ATOM   1845 C  C   . GLY A 1 274 ? -4.799  -29.257 -15.763 0.34 35.80  ? 537  GLY A C   1 
ATOM   1846 O  O   . GLY A 1 274 ? -4.617  -28.030 -15.659 0.34 35.08  ? 537  GLY A O   1 
ATOM   1847 N  N   . TRP A 1 275 ? -5.398  -29.840 -16.806 0.34 34.92  ? 538  TRP A N   1 
ATOM   1848 C  CA  . TRP A 1 275 ? -5.873  -29.108 -18.012 0.34 34.51  ? 538  TRP A CA  1 
ATOM   1849 C  C   . TRP A 1 275 ? -6.691  -27.875 -17.604 0.34 34.10  ? 538  TRP A C   1 
ATOM   1850 O  O   . TRP A 1 275 ? -6.383  -26.778 -18.112 0.34 33.14  ? 538  TRP A O   1 
ATOM   1851 C  CB  . TRP A 1 275 ? -6.685  -30.022 -18.932 0.34 33.71  ? 538  TRP A CB  1 
ATOM   1852 C  CG  . TRP A 1 275 ? -7.319  -29.284 -20.071 0.34 34.31  ? 538  TRP A CG  1 
ATOM   1853 C  CD1 . TRP A 1 275 ? -8.586  -28.779 -20.119 0.34 33.65  ? 538  TRP A CD1 1 
ATOM   1854 C  CD2 . TRP A 1 275 ? -6.715  -28.964 -21.337 0.34 34.10  ? 538  TRP A CD2 1 
ATOM   1855 N  NE1 . TRP A 1 275 ? -8.809  -28.172 -21.324 0.34 33.94  ? 538  TRP A NE1 1 
ATOM   1856 C  CE2 . TRP A 1 275 ? -7.680  -28.266 -22.090 0.34 34.16  ? 538  TRP A CE2 1 
ATOM   1857 C  CE3 . TRP A 1 275 ? -5.461  -29.201 -21.908 0.34 34.02  ? 538  TRP A CE3 1 
ATOM   1858 C  CZ2 . TRP A 1 275 ? -7.431  -27.804 -23.381 0.34 34.29  ? 538  TRP A CZ2 1 
ATOM   1859 C  CZ3 . TRP A 1 275 ? -5.213  -28.740 -23.181 0.34 34.45  ? 538  TRP A CZ3 1 
ATOM   1860 C  CH2 . TRP A 1 275 ? -6.187  -28.056 -23.908 0.34 34.60  ? 538  TRP A CH2 1 
ATOM   1861 N  N   . ASP A 1 276 ? -7.695  -28.052 -16.739 0.34 32.91  ? 539  ASP A N   1 
ATOM   1862 C  CA  . ASP A 1 276 ? -8.652  -26.981 -16.339 0.34 33.96  ? 539  ASP A CA  1 
ATOM   1863 C  C   . ASP A 1 276 ? -7.885  -25.839 -15.655 0.34 35.08  ? 539  ASP A C   1 
ATOM   1864 O  O   . ASP A 1 276 ? -8.186  -24.665 -15.954 0.34 33.23  ? 539  ASP A O   1 
ATOM   1865 C  CB  . ASP A 1 276 ? -9.770  -27.526 -15.447 0.34 32.32  ? 539  ASP A CB  1 
ATOM   1866 C  CG  . ASP A 1 276 ? -10.867 -28.251 -16.210 0.34 31.91  ? 539  ASP A CG  1 
ATOM   1867 O  OD1 . ASP A 1 276 ? -10.692 -28.460 -17.423 0.34 31.30  ? 539  ASP A OD1 1 
ATOM   1868 O  OD2 . ASP A 1 276 ? -11.889 -28.603 -15.584 0.34 31.41  ? 539  ASP A OD2 1 
ATOM   1869 N  N   . THR A 1 277 ? -6.928  -26.164 -14.779 0.34 37.15  ? 540  THR A N   1 
ATOM   1870 C  CA  . THR A 1 277 ? -6.140  -25.166 -14.005 0.34 39.25  ? 540  THR A CA  1 
ATOM   1871 C  C   . THR A 1 277 ? -5.219  -24.393 -14.957 0.34 40.73  ? 540  THR A C   1 
ATOM   1872 O  O   . THR A 1 277 ? -4.738  -23.319 -14.556 0.34 43.51  ? 540  THR A O   1 
ATOM   1873 C  CB  . THR A 1 277 ? -5.374  -25.824 -12.849 0.34 39.10  ? 540  THR A CB  1 
ATOM   1874 O  OG1 . THR A 1 277 ? -4.314  -26.624 -13.374 0.34 39.98  ? 540  THR A OG1 1 
ATOM   1875 C  CG2 . THR A 1 277 ? -6.269  -26.675 -11.975 0.34 40.10  ? 540  THR A CG2 1 
ATOM   1876 N  N   . ARG A 1 278 ? -4.998  -24.909 -16.172 0.34 41.99  ? 541  ARG A N   1 
ATOM   1877 C  CA  . ARG A 1 278 ? -4.099  -24.297 -17.188 0.34 42.49  ? 541  ARG A CA  1 
ATOM   1878 C  C   . ARG A 1 278 ? -4.923  -23.540 -18.233 0.34 42.39  ? 541  ARG A C   1 
ATOM   1879 O  O   . ARG A 1 278 ? -4.339  -23.133 -19.253 0.34 42.02  ? 541  ARG A O   1 
ATOM   1880 C  CB  . ARG A 1 278 ? -3.268  -25.357 -17.916 0.34 44.87  ? 541  ARG A CB  1 
ATOM   1881 C  CG  . ARG A 1 278 ? -2.666  -26.427 -17.019 0.34 47.68  ? 541  ARG A CG  1 
ATOM   1882 C  CD  . ARG A 1 278 ? -1.801  -25.879 -15.903 0.34 50.79  ? 541  ARG A CD  1 
ATOM   1883 N  NE  . ARG A 1 278 ? -1.035  -26.951 -15.278 0.34 55.15  ? 541  ARG A NE  1 
ATOM   1884 C  CZ  . ARG A 1 278 ? 0.279   -27.114 -15.400 0.34 55.63  ? 541  ARG A CZ  1 
ATOM   1885 N  NH1 . ARG A 1 278 ? 0.989   -26.260 -16.118 0.34 55.16  ? 541  ARG A NH1 1 
ATOM   1886 N  NH2 . ARG A 1 278 ? 0.878   -28.122 -14.793 0.34 56.92  ? 541  ARG A NH2 1 
ATOM   1887 N  N   . ILE A 1 279 ? -6.233  -23.402 -18.018 0.34 42.54  ? 542  ILE A N   1 
ATOM   1888 C  CA  . ILE A 1 279 ? -7.121  -22.590 -18.901 0.34 43.54  ? 542  ILE A CA  1 
ATOM   1889 C  C   . ILE A 1 279 ? -6.875  -21.114 -18.567 0.34 43.77  ? 542  ILE A C   1 
ATOM   1890 O  O   . ILE A 1 279 ? -7.251  -20.682 -17.460 0.34 44.50  ? 542  ILE A O   1 
ATOM   1891 C  CB  . ILE A 1 279 ? -8.600  -23.001 -18.744 0.34 43.94  ? 542  ILE A CB  1 
ATOM   1892 C  CG1 . ILE A 1 279 ? -8.816  -24.470 -19.117 0.34 44.07  ? 542  ILE A CG1 1 
ATOM   1893 C  CG2 . ILE A 1 279 ? -9.509  -22.087 -19.553 0.34 42.72  ? 542  ILE A CG2 1 
ATOM   1894 C  CD1 . ILE A 1 279 ? -8.547  -24.773 -20.571 0.34 44.28  ? 542  ILE A CD1 1 
ATOM   1895 N  N   . THR A 1 280 ? -6.234  -20.386 -19.485 1.00 44.87  ? 543  THR A N   1 
ATOM   1896 C  CA  . THR A 1 280 ? -5.822  -18.977 -19.284 1.00 45.85  ? 543  THR A CA  1 
ATOM   1897 C  C   . THR A 1 280 ? -7.029  -18.078 -19.539 1.00 49.72  ? 543  THR A C   1 
ATOM   1898 O  O   . THR A 1 280 ? -8.011  -18.567 -20.123 1.00 48.72  ? 543  THR A O   1 
ATOM   1899 C  CB  . THR A 1 280 ? -4.653  -18.658 -20.212 1.00 43.91  ? 543  THR A CB  1 
ATOM   1900 O  OG1 . THR A 1 280 ? -5.107  -18.717 -21.564 1.00 43.27  ? 543  THR A OG1 1 
ATOM   1901 C  CG2 . THR A 1 280 ? -3.507  -19.627 -20.035 1.00 47.98  ? 543  THR A CG2 1 
ATOM   1902 N  N   . LEU A 1 281 ? -6.972  -16.817 -19.121 1.00 53.43  ? 544  LEU A N   1 
ATOM   1903 C  CA  . LEU A 1 281 ? -8.012  -15.837 -19.524 1.00 56.08  ? 544  LEU A CA  1 
ATOM   1904 C  C   . LEU A 1 281 ? -7.958  -15.687 -21.052 1.00 50.10  ? 544  LEU A C   1 
ATOM   1905 O  O   . LEU A 1 281 ? -9.005  -15.513 -21.637 1.00 43.68  ? 544  LEU A O   1 
ATOM   1906 C  CB  . LEU A 1 281 ? -7.813  -14.499 -18.803 1.00 66.27  ? 544  LEU A CB  1 
ATOM   1907 C  CG  . LEU A 1 281 ? -8.792  -13.395 -19.215 1.00 70.25  ? 544  LEU A CG  1 
ATOM   1908 C  CD1 . LEU A 1 281 ? -10.243 -13.812 -18.987 1.00 62.13  ? 544  LEU A CD1 1 
ATOM   1909 C  CD2 . LEU A 1 281 ? -8.483  -12.099 -18.482 1.00 74.06  ? 544  LEU A CD2 1 
ATOM   1910 N  N   . GLU A 1 282 ? -6.790  -15.835 -21.683 1.00 50.33  ? 545  GLU A N   1 
ATOM   1911 C  CA  . GLU A 1 282 ? -6.659  -15.721 -23.166 1.00 48.70  ? 545  GLU A CA  1 
ATOM   1912 C  C   . GLU A 1 282 ? -7.447  -16.844 -23.876 1.00 48.03  ? 545  GLU A C   1 
ATOM   1913 O  O   . GLU A 1 282 ? -8.051  -16.601 -24.982 1.00 44.55  ? 545  GLU A O   1 
ATOM   1914 C  CB  . GLU A 1 282 ? -5.180  -15.663 -23.527 1.00 53.99  ? 545  GLU A CB  1 
ATOM   1915 C  CG  . GLU A 1 282 ? -4.933  -14.994 -24.866 1.00 64.63  ? 545  GLU A CG  1 
ATOM   1916 C  CD  . GLU A 1 282 ? -5.283  -13.515 -24.980 1.00 65.71  ? 545  GLU A CD  1 
ATOM   1917 O  OE1 . GLU A 1 282 ? -5.358  -12.818 -23.926 1.00 63.06  ? 545  GLU A OE1 1 
ATOM   1918 O  OE2 . GLU A 1 282 ? -5.471  -13.065 -26.130 1.00 67.21  ? 545  GLU A OE2 1 
ATOM   1919 N  N   . ASP A 1 283 ? -7.485  -18.033 -23.268 0.34 46.81  ? 546  ASP A N   1 
ATOM   1920 C  CA  . ASP A 1 283 ? -8.274  -19.194 -23.762 0.34 45.56  ? 546  ASP A CA  1 
ATOM   1921 C  C   . ASP A 1 283 ? -9.772  -18.909 -23.566 0.34 44.68  ? 546  ASP A C   1 
ATOM   1922 O  O   . ASP A 1 283 ? -10.547 -19.165 -24.512 0.34 44.15  ? 546  ASP A O   1 
ATOM   1923 C  CB  . ASP A 1 283 ? -7.830  -20.490 -23.078 0.34 44.73  ? 546  ASP A CB  1 
ATOM   1924 C  CG  . ASP A 1 283 ? -6.452  -20.965 -23.509 0.34 44.11  ? 546  ASP A CG  1 
ATOM   1925 O  OD1 . ASP A 1 283 ? -6.101  -20.759 -24.688 0.34 44.44  ? 546  ASP A OD1 1 
ATOM   1926 O  OD2 . ASP A 1 283 ? -5.741  -21.535 -22.662 0.34 42.50  ? 546  ASP A OD2 1 
ATOM   1927 N  N   . LEU A 1 284 ? -10.166 -18.406 -22.390 1.00 42.58  ? 547  LEU A N   1 
ATOM   1928 C  CA  . LEU A 1 284 ? -11.588 -18.028 -22.100 1.00 45.11  ? 547  LEU A CA  1 
ATOM   1929 C  C   . LEU A 1 284 ? -12.121 -16.965 -23.082 1.00 46.91  ? 547  LEU A C   1 
ATOM   1930 O  O   . LEU A 1 284 ? -13.312 -16.982 -23.388 1.00 50.35  ? 547  LEU A O   1 
ATOM   1931 C  CB  . LEU A 1 284 ? -11.691 -17.526 -20.660 1.00 41.49  ? 547  LEU A CB  1 
ATOM   1932 C  CG  . LEU A 1 284 ? -11.589 -18.610 -19.596 1.00 41.76  ? 547  LEU A CG  1 
ATOM   1933 C  CD1 . LEU A 1 284 ? -11.561 -18.010 -18.199 1.00 46.11  ? 547  LEU A CD1 1 
ATOM   1934 C  CD2 . LEU A 1 284 ? -12.724 -19.613 -19.711 1.00 42.76  ? 547  LEU A CD2 1 
ATOM   1935 N  N   . LYS A 1 285 ? -11.233 -16.090 -23.568 0.34 47.42  ? 548  LYS A N   1 
ATOM   1936 C  CA  . LYS A 1 285 ? -11.547 -14.974 -24.501 0.34 47.81  ? 548  LYS A CA  1 
ATOM   1937 C  C   . LYS A 1 285 ? -11.647 -15.502 -25.940 0.34 47.11  ? 548  LYS A C   1 
ATOM   1938 O  O   . LYS A 1 285 ? -12.479 -14.966 -26.698 0.34 47.74  ? 548  LYS A O   1 
ATOM   1939 C  CB  . LYS A 1 285 ? -10.496 -13.865 -24.369 0.34 47.62  ? 548  LYS A CB  1 
ATOM   1940 C  CG  . LYS A 1 285 ? -10.630 -13.000 -23.119 0.34 48.61  ? 548  LYS A CG  1 
ATOM   1941 C  CD  . LYS A 1 285 ? -9.489  -12.012 -22.922 0.34 50.11  ? 548  LYS A CD  1 
ATOM   1942 C  CE  . LYS A 1 285 ? -9.723  -11.034 -21.787 0.34 50.23  ? 548  LYS A CE  1 
ATOM   1943 N  NZ  . LYS A 1 285 ? -8.480  -10.318 -21.409 0.34 50.34  ? 548  LYS A NZ  1 
ATOM   1944 N  N   . ASN A 1 286 ? -10.834 -16.497 -26.309 1.00 46.24  ? 549  ASN A N   1 
ATOM   1945 C  CA  . ASN A 1 286 ? -10.922 -17.142 -27.649 1.00 45.24  ? 549  ASN A CA  1 
ATOM   1946 C  C   . ASN A 1 286 ? -12.171 -18.038 -27.727 1.00 39.76  ? 549  ASN A C   1 
ATOM   1947 O  O   . ASN A 1 286 ? -12.728 -18.179 -28.829 1.00 38.87  ? 549  ASN A O   1 
ATOM   1948 C  CB  . ASN A 1 286 ? -9.670  -17.939 -27.980 1.00 43.56  ? 549  ASN A CB  1 
ATOM   1949 C  CG  . ASN A 1 286 ? -8.465  -17.035 -28.117 1.00 48.87  ? 549  ASN A CG  1 
ATOM   1950 O  OD1 . ASN A 1 286 ? -8.520  -16.006 -28.785 1.00 46.22  ? 549  ASN A OD1 1 
ATOM   1951 N  ND2 . ASN A 1 286 ? -7.366  -17.420 -27.500 1.00 52.01  ? 549  ASN A ND2 1 
ATOM   1952 N  N   . GLU A 1 287 ? -12.565 -18.646 -26.612 1.00 38.38  ? 550  GLU A N   1 
ATOM   1953 C  CA  . GLU A 1 287 ? -13.790 -19.489 -26.507 1.00 41.94  ? 550  GLU A CA  1 
ATOM   1954 C  C   . GLU A 1 287 ? -15.037 -18.603 -26.690 1.00 40.18  ? 550  GLU A C   1 
ATOM   1955 O  O   . GLU A 1 287 ? -15.907 -18.994 -27.481 1.00 42.91  ? 550  GLU A O   1 
ATOM   1956 C  CB  . GLU A 1 287 ? -13.776 -20.247 -25.181 1.00 37.47  ? 550  GLU A CB  1 
ATOM   1957 C  CG  . GLU A 1 287 ? -12.808 -21.406 -25.208 1.00 41.22  ? 550  GLU A CG  1 
ATOM   1958 C  CD  . GLU A 1 287 ? -12.411 -21.956 -23.849 1.00 46.73  ? 550  GLU A CD  1 
ATOM   1959 O  OE1 . GLU A 1 287 ? -13.136 -21.689 -22.852 1.00 43.25  ? 550  GLU A OE1 1 
ATOM   1960 O  OE2 . GLU A 1 287 ? -11.390 -22.689 -23.790 1.00 47.46  ? 550  GLU A OE2 1 
ATOM   1961 N  N   . GLU A 1 288 ? -15.056 -17.434 -26.045 1.00 40.29  ? 551  GLU A N   1 
ATOM   1962 C  CA  . GLU A 1 288 ? -16.096 -16.370 -26.169 1.00 42.69  ? 551  GLU A CA  1 
ATOM   1963 C  C   . GLU A 1 288 ? -16.322 -15.958 -27.632 1.00 41.02  ? 551  GLU A C   1 
ATOM   1964 O  O   . GLU A 1 288 ? -17.432 -15.542 -27.944 1.00 46.68  ? 551  GLU A O   1 
ATOM   1965 C  CB  . GLU A 1 288 ? -15.708 -15.150 -25.330 1.00 48.29  ? 551  GLU A CB  1 
ATOM   1966 C  CG  . GLU A 1 288 ? -16.857 -14.213 -24.970 1.00 53.38  ? 551  GLU A CG  1 
ATOM   1967 C  CD  . GLU A 1 288 ? -17.144 -13.011 -25.877 1.00 58.69  ? 551  GLU A CD  1 
ATOM   1968 O  OE1 . GLU A 1 288 ? -16.374 -12.758 -26.838 1.00 59.72  ? 551  GLU A OE1 1 
ATOM   1969 O  OE2 . GLU A 1 288 ? -18.157 -12.311 -25.618 1.00 62.28  ? 551  GLU A OE2 1 
ATOM   1970 N  N   . MET A 1 289 ? -15.362 -16.106 -28.534 1.00 39.15  ? 552  MET A N   1 
ATOM   1971 C  CA  . MET A 1 289 ? -15.573 -15.673 -29.936 1.00 41.27  ? 552  MET A CA  1 
ATOM   1972 C  C   . MET A 1 289 ? -16.675 -16.509 -30.587 1.00 41.88  ? 552  MET A C   1 
ATOM   1973 O  O   . MET A 1 289 ? -17.081 -16.170 -31.726 1.00 47.14  ? 552  MET A O   1 
ATOM   1974 C  CB  . MET A 1 289 ? -14.287 -15.765 -30.762 1.00 42.69  ? 552  MET A CB  1 
ATOM   1975 C  CG  . MET A 1 289 ? -13.204 -14.817 -30.253 1.00 49.52  ? 552  MET A CG  1 
ATOM   1976 S  SD  . MET A 1 289 ? -11.897 -14.430 -31.472 1.00 57.88  ? 552  MET A SD  1 
ATOM   1977 C  CE  . MET A 1 289 ? -11.558 -16.025 -32.200 1.00 55.30  ? 552  MET A CE  1 
ATOM   1978 N  N   . VAL A 1 290 ? -17.163 -17.577 -29.952 1.00 41.94  ? 553  VAL A N   1 
ATOM   1979 C  CA  . VAL A 1 290 ? -18.366 -18.286 -30.503 1.00 40.23  ? 553  VAL A CA  1 
ATOM   1980 C  C   . VAL A 1 290 ? -19.550 -17.299 -30.577 1.00 37.58  ? 553  VAL A C   1 
ATOM   1981 O  O   . VAL A 1 290 ? -20.357 -17.435 -31.529 1.00 41.39  ? 553  VAL A O   1 
ATOM   1982 C  CB  . VAL A 1 290 ? -18.742 -19.569 -29.736 1.00 35.09  ? 553  VAL A CB  1 
ATOM   1983 C  CG1 . VAL A 1 290 ? -19.210 -19.299 -28.317 1.00 34.77  ? 553  VAL A CG1 1 
ATOM   1984 C  CG2 . VAL A 1 290 ? -19.781 -20.384 -30.489 1.00 35.34  ? 553  VAL A CG2 1 
ATOM   1985 N  N   . THR A 1 291 ? -19.676 -16.352 -29.639 1.00 36.78  ? 554  THR A N   1 
ATOM   1986 C  CA  . THR A 1 291 ? -20.781 -15.346 -29.638 1.00 41.43  ? 554  THR A CA  1 
ATOM   1987 C  C   . THR A 1 291 ? -20.796 -14.515 -30.926 1.00 42.27  ? 554  THR A C   1 
ATOM   1988 O  O   . THR A 1 291 ? -21.905 -14.064 -31.317 1.00 42.67  ? 554  THR A O   1 
ATOM   1989 C  CB  . THR A 1 291 ? -20.718 -14.377 -28.463 1.00 40.34  ? 554  THR A CB  1 
ATOM   1990 O  OG1 . THR A 1 291 ? -19.439 -13.739 -28.511 1.00 44.73  ? 554  THR A OG1 1 
ATOM   1991 C  CG2 . THR A 1 291 ? -20.949 -15.068 -27.141 1.00 37.23  ? 554  THR A CG2 1 
ATOM   1992 N  N   . ASN A 1 292 ? -19.649 -14.345 -31.593 1.00 45.34  ? 555  ASN A N   1 
ATOM   1993 C  CA  . ASN A 1 292 ? -19.570 -13.634 -32.903 1.00 45.70  ? 555  ASN A CA  1 
ATOM   1994 C  C   . ASN A 1 292 ? -20.394 -14.337 -33.983 1.00 50.12  ? 555  ASN A C   1 
ATOM   1995 O  O   . ASN A 1 292 ? -20.481 -13.776 -35.107 1.00 57.57  ? 555  ASN A O   1 
ATOM   1996 C  CB  . ASN A 1 292 ? -18.165 -13.564 -33.502 1.00 46.33  ? 555  ASN A CB  1 
ATOM   1997 C  CG  . ASN A 1 292 ? -17.185 -12.810 -32.638 1.00 48.17  ? 555  ASN A CG  1 
ATOM   1998 O  OD1 . ASN A 1 292 ? -17.581 -12.066 -31.748 1.00 53.47  ? 555  ASN A OD1 1 
ATOM   1999 N  ND2 . ASN A 1 292 ? -15.905 -13.037 -32.880 1.00 51.27  ? 555  ASN A ND2 1 
ATOM   2000 N  N   . HIS A 1 293 ? -20.907 -15.541 -33.726 1.00 44.89  ? 556  HIS A N   1 
ATOM   2001 C  CA  . HIS A 1 293 ? -21.667 -16.328 -34.738 1.00 49.68  ? 556  HIS A CA  1 
ATOM   2002 C  C   . HIS A 1 293 ? -23.158 -16.273 -34.392 1.00 44.96  ? 556  HIS A C   1 
ATOM   2003 O  O   . HIS A 1 293 ? -23.949 -16.906 -35.096 1.00 44.39  ? 556  HIS A O   1 
ATOM   2004 C  CB  . HIS A 1 293 ? -21.065 -17.741 -34.866 1.00 50.65  ? 556  HIS A CB  1 
ATOM   2005 C  CG  . HIS A 1 293 ? -19.647 -17.697 -35.326 1.00 52.95  ? 556  HIS A CG  1 
ATOM   2006 N  ND1 . HIS A 1 293 ? -19.296 -17.898 -36.643 1.00 51.41  ? 556  HIS A ND1 1 
ATOM   2007 C  CD2 . HIS A 1 293 ? -18.500 -17.415 -34.668 1.00 54.56  ? 556  HIS A CD2 1 
ATOM   2008 C  CE1 . HIS A 1 293 ? -17.993 -17.752 -36.777 1.00 48.25  ? 556  HIS A CE1 1 
ATOM   2009 N  NE2 . HIS A 1 293 ? -17.484 -17.460 -35.587 1.00 54.69  ? 556  HIS A NE2 1 
ATOM   2010 N  N   . MET A 1 294 ? -23.485 -15.533 -33.333 1.00 45.35  ? 557  MET A N   1 
ATOM   2011 C  CA  . MET A 1 294 ? -24.811 -15.485 -32.674 1.00 50.55  ? 557  MET A CA  1 
ATOM   2012 C  C   . MET A 1 294 ? -25.501 -14.172 -33.058 1.00 52.29  ? 557  MET A C   1 
ATOM   2013 O  O   . MET A 1 294 ? -24.876 -13.351 -33.748 1.00 52.74  ? 557  MET A O   1 
ATOM   2014 C  CB  . MET A 1 294 ? -24.669 -15.546 -31.148 1.00 47.90  ? 557  MET A CB  1 
ATOM   2015 C  CG  . MET A 1 294 ? -24.134 -16.875 -30.641 1.00 48.02  ? 557  MET A CG  1 
ATOM   2016 S  SD  . MET A 1 294 ? -24.189 -16.981 -28.849 1.00 45.72  ? 557  MET A SD  1 
ATOM   2017 C  CE  . MET A 1 294 ? -23.048 -18.348 -28.639 1.00 49.31  ? 557  MET A CE  1 
ATOM   2018 N  N   . GLU A 1 295 ? -26.748 -14.002 -32.620 1.00 55.98  ? 558  GLU A N   1 
ATOM   2019 C  CA  . GLU A 1 295 ? -27.554 -12.798 -32.925 1.00 57.14  ? 558  GLU A CA  1 
ATOM   2020 C  C   . GLU A 1 295 ? -28.625 -12.558 -31.866 1.00 57.30  ? 558  GLU A C   1 
ATOM   2021 O  O   . GLU A 1 295 ? -28.967 -13.498 -31.114 1.00 54.72  ? 558  GLU A O   1 
ATOM   2022 C  CB  . GLU A 1 295 ? -28.203 -12.965 -34.288 1.00 57.92  ? 558  GLU A CB  1 
ATOM   2023 C  CG  . GLU A 1 295 ? -29.298 -13.993 -34.324 1.00 61.33  ? 558  GLU A CG  1 
ATOM   2024 C  CD  . GLU A 1 295 ? -29.899 -14.106 -35.708 1.00 73.53  ? 558  GLU A CD  1 
ATOM   2025 O  OE1 . GLU A 1 295 ? -29.124 -14.087 -36.719 1.00 74.76  ? 558  GLU A OE1 1 
ATOM   2026 O  OE2 . GLU A 1 295 ? -31.139 -14.170 -35.775 1.00 86.40  ? 558  GLU A OE2 1 
ATOM   2027 N  N   . GLY A 1 296 ? -29.135 -11.324 -31.854 1.00 64.95  ? 559  GLY A N   1 
ATOM   2028 C  CA  . GLY A 1 296 ? -30.234 -10.867 -30.992 1.00 54.83  ? 559  GLY A CA  1 
ATOM   2029 C  C   . GLY A 1 296 ? -29.950 -11.169 -29.539 1.00 57.51  ? 559  GLY A C   1 
ATOM   2030 O  O   . GLY A 1 296 ? -28.770 -11.003 -29.109 1.00 52.09  ? 559  GLY A O   1 
ATOM   2031 N  N   . GLU A 1 297 ? -30.994 -11.617 -28.838 1.00 50.03  ? 560  GLU A N   1 
ATOM   2032 C  CA  . GLU A 1 297 ? -30.994 -11.938 -27.392 1.00 57.59  ? 560  GLU A CA  1 
ATOM   2033 C  C   . GLU A 1 297 ? -29.883 -12.955 -27.084 1.00 58.87  ? 560  GLU A C   1 
ATOM   2034 O  O   . GLU A 1 297 ? -29.117 -12.732 -26.126 1.00 60.17  ? 560  GLU A O   1 
ATOM   2035 C  CB  . GLU A 1 297 ? -32.358 -12.503 -27.005 1.00 62.20  ? 560  GLU A CB  1 
ATOM   2036 C  CG  . GLU A 1 297 ? -32.670 -12.327 -25.535 1.00 71.04  ? 560  GLU A CG  1 
ATOM   2037 C  CD  . GLU A 1 297 ? -34.110 -12.632 -25.172 1.00 80.45  ? 560  GLU A CD  1 
ATOM   2038 O  OE1 . GLU A 1 297 ? -34.518 -13.796 -25.362 1.00 84.20  ? 560  GLU A OE1 1 
ATOM   2039 O  OE2 . GLU A 1 297 ? -34.818 -11.705 -24.700 1.00 91.85  ? 560  GLU A OE2 1 
ATOM   2040 N  N   . HIS A 1 298 ? -29.816 -14.030 -27.873 1.00 53.42  ? 561  HIS A N   1 
ATOM   2041 C  CA  . HIS A 1 298 ? -28.884 -15.169 -27.675 1.00 55.07  ? 561  HIS A CA  1 
ATOM   2042 C  C   . HIS A 1 298 ? -27.473 -14.604 -27.479 1.00 52.35  ? 561  HIS A C   1 
ATOM   2043 O  O   . HIS A 1 298 ? -26.883 -14.858 -26.415 1.00 52.27  ? 561  HIS A O   1 
ATOM   2044 C  CB  . HIS A 1 298 ? -28.994 -16.176 -28.823 1.00 52.19  ? 561  HIS A CB  1 
ATOM   2045 C  CG  . HIS A 1 298 ? -28.152 -17.391 -28.606 1.00 55.54  ? 561  HIS A CG  1 
ATOM   2046 N  ND1 . HIS A 1 298 ? -27.771 -18.225 -29.639 1.00 53.05  ? 561  HIS A ND1 1 
ATOM   2047 C  CD2 . HIS A 1 298 ? -27.611 -17.905 -27.481 1.00 50.92  ? 561  HIS A CD2 1 
ATOM   2048 C  CE1 . HIS A 1 298 ? -27.040 -19.199 -29.155 1.00 56.70  ? 561  HIS A CE1 1 
ATOM   2049 N  NE2 . HIS A 1 298 ? -26.930 -19.024 -27.836 1.00 54.80  ? 561  HIS A NE2 1 
ATOM   2050 N  N   . LYS A 1 299 ? -27.023 -13.780 -28.420 1.00 47.14  ? 562  LYS A N   1 
ATOM   2051 C  CA  . LYS A 1 299 ? -25.673 -13.179 -28.422 1.00 51.74  ? 562  LYS A CA  1 
ATOM   2052 C  C   . LYS A 1 299 ? -25.438 -12.469 -27.083 1.00 57.69  ? 562  LYS A C   1 
ATOM   2053 O  O   . LYS A 1 299 ? -24.332 -12.615 -26.530 1.00 56.57  ? 562  LYS A O   1 
ATOM   2054 C  CB  . LYS A 1 299 ? -25.523 -12.251 -29.627 1.00 50.51  ? 562  LYS A CB  1 
ATOM   2055 C  CG  . LYS A 1 299 ? -24.225 -11.453 -29.647 1.00 51.12  ? 562  LYS A CG  1 
ATOM   2056 C  CD  . LYS A 1 299 ? -23.900 -10.877 -31.002 1.00 54.80  ? 562  LYS A CD  1 
ATOM   2057 C  CE  . LYS A 1 299 ? -22.818 -9.821  -30.970 1.00 59.93  ? 562  LYS A CE  1 
ATOM   2058 N  NZ  . LYS A 1 299 ? -21.465 -10.412 -30.872 1.00 69.73  ? 562  LYS A NZ  1 
ATOM   2059 N  N   . LYS A 1 300 ? -26.443 -11.752 -26.573 1.00 61.19  ? 563  LYS A N   1 
ATOM   2060 C  CA  . LYS A 1 300 ? -26.356 -11.011 -25.283 1.00 63.18  ? 563  LYS A CA  1 
ATOM   2061 C  C   . LYS A 1 300 ? -26.272 -12.020 -24.151 1.00 50.35  ? 563  LYS A C   1 
ATOM   2062 O  O   . LYS A 1 300 ? -25.410 -11.853 -23.300 1.00 56.71  ? 563  LYS A O   1 
ATOM   2063 C  CB  . LYS A 1 300 ? -27.578 -10.127 -24.981 1.00 75.31  ? 563  LYS A CB  1 
ATOM   2064 C  CG  . LYS A 1 300 ? -27.906 -9.046  -26.005 1.00 86.39  ? 563  LYS A CG  1 
ATOM   2065 C  CD  . LYS A 1 300 ? -26.933 -7.890  -26.028 1.00 94.29  ? 563  LYS A CD  1 
ATOM   2066 C  CE  . LYS A 1 300 ? -27.141 -6.984  -27.226 1.00 102.99 ? 563  LYS A CE  1 
ATOM   2067 N  NZ  . LYS A 1 300 ? -26.112 -5.920  -27.299 1.00 110.72 ? 563  LYS A NZ  1 
ATOM   2068 N  N   . LEU A 1 301 ? -27.181 -12.993 -24.139 1.00 49.59  ? 564  LEU A N   1 
ATOM   2069 C  CA  . LEU A 1 301 ? -27.266 -14.013 -23.063 1.00 54.54  ? 564  LEU A CA  1 
ATOM   2070 C  C   . LEU A 1 301 ? -25.926 -14.780 -22.989 1.00 61.19  ? 564  LEU A C   1 
ATOM   2071 O  O   . LEU A 1 301 ? -25.365 -14.870 -21.876 1.00 58.36  ? 564  LEU A O   1 
ATOM   2072 C  CB  . LEU A 1 301 ? -28.456 -14.940 -23.335 1.00 53.60  ? 564  LEU A CB  1 
ATOM   2073 C  CG  . LEU A 1 301 ? -29.857 -14.368 -23.060 1.00 54.94  ? 564  LEU A CG  1 
ATOM   2074 C  CD1 . LEU A 1 301 ? -30.920 -15.280 -23.642 1.00 53.20  ? 564  LEU A CD1 1 
ATOM   2075 C  CD2 . LEU A 1 301 ? -30.122 -14.170 -21.572 1.00 53.62  ? 564  LEU A CD2 1 
ATOM   2076 N  N   . ALA A 1 302 ? -25.406 -15.266 -24.126 1.00 51.37  ? 565  ALA A N   1 
ATOM   2077 C  CA  . ALA A 1 302 ? -24.112 -15.984 -24.225 1.00 51.20  ? 565  ALA A CA  1 
ATOM   2078 C  C   . ALA A 1 302 ? -22.985 -15.063 -23.751 1.00 53.39  ? 565  ALA A C   1 
ATOM   2079 O  O   . ALA A 1 302 ? -22.165 -15.521 -22.952 1.00 59.34  ? 565  ALA A O   1 
ATOM   2080 C  CB  . ALA A 1 302 ? -23.864 -16.469 -25.639 1.00 49.48  ? 565  ALA A CB  1 
ATOM   2081 N  N   . GLU A 1 303 ? -22.954 -13.813 -24.214 1.00 50.21  ? 566  GLU A N   1 
ATOM   2082 C  CA  . GLU A 1 303 ? -21.898 -12.835 -23.839 1.00 51.60  ? 566  GLU A CA  1 
ATOM   2083 C  C   . GLU A 1 303 ? -21.861 -12.670 -22.319 1.00 49.02  ? 566  GLU A C   1 
ATOM   2084 O  O   . GLU A 1 303 ? -20.755 -12.507 -21.748 1.00 45.96  ? 566  GLU A O   1 
ATOM   2085 C  CB  . GLU A 1 303 ? -22.140 -11.493 -24.519 1.00 53.85  ? 566  GLU A CB  1 
ATOM   2086 C  CG  . GLU A 1 303 ? -21.607 -11.468 -25.935 1.00 59.77  ? 566  GLU A CG  1 
ATOM   2087 C  CD  . GLU A 1 303 ? -22.013 -10.257 -26.752 1.00 65.51  ? 566  GLU A CD  1 
ATOM   2088 O  OE1 . GLU A 1 303 ? -22.573 -9.310  -26.170 1.00 72.51  ? 566  GLU A OE1 1 
ATOM   2089 O  OE2 . GLU A 1 303 ? -21.760 -10.268 -27.975 1.00 74.76  ? 566  GLU A OE2 1 
ATOM   2090 N  N   . ALA A 1 304 ? -23.022 -12.725 -21.685 1.00 44.57  ? 567  ALA A N   1 
ATOM   2091 C  CA  . ALA A 1 304 ? -23.149 -12.513 -20.229 1.00 52.36  ? 567  ALA A CA  1 
ATOM   2092 C  C   . ALA A 1 304 ? -22.549 -13.720 -19.501 1.00 49.91  ? 567  ALA A C   1 
ATOM   2093 O  O   . ALA A 1 304 ? -21.754 -13.490 -18.580 1.00 51.28  ? 567  ALA A O   1 
ATOM   2094 C  CB  . ALA A 1 304 ? -24.590 -12.260 -19.836 1.00 50.84  ? 567  ALA A CB  1 
ATOM   2095 N  N   . ILE A 1 305 ? -22.896 -14.948 -19.909 1.00 49.79  ? 568  ILE A N   1 
ATOM   2096 C  CA  . ILE A 1 305 ? -22.356 -16.177 -19.260 1.00 48.67  ? 568  ILE A CA  1 
ATOM   2097 C  C   . ILE A 1 305 ? -20.817 -16.071 -19.303 1.00 47.49  ? 568  ILE A C   1 
ATOM   2098 O  O   . ILE A 1 305 ? -20.202 -16.142 -18.247 1.00 47.22  ? 568  ILE A O   1 
ATOM   2099 C  CB  . ILE A 1 305 ? -22.899 -17.459 -19.924 1.00 55.63  ? 568  ILE A CB  1 
ATOM   2100 C  CG1 . ILE A 1 305 ? -24.414 -17.636 -19.722 1.00 55.49  ? 568  ILE A CG1 1 
ATOM   2101 C  CG2 . ILE A 1 305 ? -22.121 -18.701 -19.468 1.00 53.02  ? 568  ILE A CG2 1 
ATOM   2102 C  CD1 . ILE A 1 305 ? -24.901 -17.607 -18.280 1.00 50.84  ? 568  ILE A CD1 1 
ATOM   2103 N  N   . PHE A 1 306 ? -20.224 -15.811 -20.469 1.00 44.23  ? 569  PHE A N   1 
ATOM   2104 C  CA  . PHE A 1 306 ? -18.752 -15.741 -20.664 1.00 49.78  ? 569  PHE A CA  1 
ATOM   2105 C  C   . PHE A 1 306 ? -18.142 -14.642 -19.787 1.00 56.71  ? 569  PHE A C   1 
ATOM   2106 O  O   . PHE A 1 306 ? -17.174 -14.947 -19.071 1.00 57.96  ? 569  PHE A O   1 
ATOM   2107 C  CB  . PHE A 1 306 ? -18.383 -15.504 -22.129 1.00 49.12  ? 569  PHE A CB  1 
ATOM   2108 C  CG  . PHE A 1 306 ? -18.287 -16.765 -22.945 1.00 53.16  ? 569  PHE A CG  1 
ATOM   2109 C  CD1 . PHE A 1 306 ? -17.228 -17.639 -22.761 1.00 56.11  ? 569  PHE A CD1 1 
ATOM   2110 C  CD2 . PHE A 1 306 ? -19.237 -17.068 -23.905 1.00 48.94  ? 569  PHE A CD2 1 
ATOM   2111 C  CE1 . PHE A 1 306 ? -17.143 -18.802 -23.507 1.00 57.95  ? 569  PHE A CE1 1 
ATOM   2112 C  CE2 . PHE A 1 306 ? -19.151 -18.234 -24.648 1.00 53.37  ? 569  PHE A CE2 1 
ATOM   2113 C  CZ  . PHE A 1 306 ? -18.112 -19.105 -24.435 1.00 54.88  ? 569  PHE A CZ  1 
ATOM   2114 N  N   . LYS A 1 307 ? -18.694 -13.422 -19.845 1.00 63.00  ? 570  LYS A N   1 
ATOM   2115 C  CA  . LYS A 1 307 ? -18.226 -12.227 -19.082 1.00 62.28  ? 570  LYS A CA  1 
ATOM   2116 C  C   . LYS A 1 307 ? -18.374 -12.436 -17.573 1.00 52.05  ? 570  LYS A C   1 
ATOM   2117 O  O   . LYS A 1 307 ? -17.412 -12.200 -16.860 1.00 53.12  ? 570  LYS A O   1 
ATOM   2118 C  CB  . LYS A 1 307 ? -19.024 -10.971 -19.451 1.00 68.73  ? 570  LYS A CB  1 
ATOM   2119 C  CG  . LYS A 1 307 ? -18.268 -9.909  -20.234 1.00 76.40  ? 570  LYS A CG  1 
ATOM   2120 C  CD  . LYS A 1 307 ? -18.686 -8.502  -19.834 1.00 91.29  ? 570  LYS A CD  1 
ATOM   2121 C  CE  . LYS A 1 307 ? -18.063 -7.424  -20.695 1.00 102.15 ? 570  LYS A CE  1 
ATOM   2122 N  NZ  . LYS A 1 307 ? -18.505 -7.534  -22.107 1.00 109.46 ? 570  LYS A NZ  1 
ATOM   2123 N  N   . LEU A 1 308 ? -19.542 -12.865 -17.106 1.00 51.13  ? 571  LEU A N   1 
ATOM   2124 C  CA  . LEU A 1 308 ? -19.943 -12.715 -15.683 1.00 55.90  ? 571  LEU A CA  1 
ATOM   2125 C  C   . LEU A 1 308 ? -19.704 -14.013 -14.901 1.00 57.83  ? 571  LEU A C   1 
ATOM   2126 O  O   . LEU A 1 308 ? -19.468 -13.917 -13.695 1.00 60.47  ? 571  LEU A O   1 
ATOM   2127 C  CB  . LEU A 1 308 ? -21.418 -12.282 -15.634 1.00 57.75  ? 571  LEU A CB  1 
ATOM   2128 C  CG  . LEU A 1 308 ? -21.769 -11.077 -16.522 1.00 60.84  ? 571  LEU A CG  1 
ATOM   2129 C  CD1 . LEU A 1 308 ? -23.271 -10.847 -16.586 1.00 58.27  ? 571  LEU A CD1 1 
ATOM   2130 C  CD2 . LEU A 1 308 ? -21.055 -9.813  -16.063 1.00 56.69  ? 571  LEU A CD2 1 
ATOM   2131 N  N   . THR A 1 309 ? -19.822 -15.184 -15.528 1.00 55.31  ? 572  THR A N   1 
ATOM   2132 C  CA  . THR A 1 309 ? -19.683 -16.489 -14.826 1.00 56.84  ? 572  THR A CA  1 
ATOM   2133 C  C   . THR A 1 309 ? -18.344 -17.163 -15.163 1.00 51.34  ? 572  THR A C   1 
ATOM   2134 O  O   . THR A 1 309 ? -17.861 -17.863 -14.304 1.00 57.64  ? 572  THR A O   1 
ATOM   2135 C  CB  . THR A 1 309 ? -20.874 -17.414 -15.104 1.00 57.91  ? 572  THR A CB  1 
ATOM   2136 O  OG1 . THR A 1 309 ? -20.950 -17.629 -16.514 1.00 55.94  ? 572  THR A OG1 1 
ATOM   2137 C  CG2 . THR A 1 309 ? -22.184 -16.847 -14.607 1.00 64.66  ? 572  THR A CG2 1 
ATOM   2138 N  N   . TYR A 1 310 ? -17.779 -16.987 -16.359 1.00 53.30  ? 573  TYR A N   1 
ATOM   2139 C  CA  . TYR A 1 310 ? -16.566 -17.735 -16.810 1.00 58.87  ? 573  TYR A CA  1 
ATOM   2140 C  C   . TYR A 1 310 ? -15.315 -16.861 -16.598 1.00 59.60  ? 573  TYR A C   1 
ATOM   2141 O  O   . TYR A 1 310 ? -14.379 -17.341 -15.943 1.00 64.13  ? 573  TYR A O   1 
ATOM   2142 C  CB  . TYR A 1 310 ? -16.691 -18.226 -18.267 1.00 52.53  ? 573  TYR A CB  1 
ATOM   2143 C  CG  . TYR A 1 310 ? -17.726 -19.297 -18.551 1.00 44.94  ? 573  TYR A CG  1 
ATOM   2144 C  CD1 . TYR A 1 310 ? -18.516 -19.850 -17.555 1.00 42.99  ? 573  TYR A CD1 1 
ATOM   2145 C  CD2 . TYR A 1 310 ? -17.919 -19.763 -19.838 1.00 43.64  ? 573  TYR A CD2 1 
ATOM   2146 C  CE1 . TYR A 1 310 ? -19.470 -20.812 -17.830 1.00 39.32  ? 573  TYR A CE1 1 
ATOM   2147 C  CE2 . TYR A 1 310 ? -18.852 -20.744 -20.127 1.00 42.06  ? 573  TYR A CE2 1 
ATOM   2148 C  CZ  . TYR A 1 310 ? -19.625 -21.276 -19.121 1.00 40.89  ? 573  TYR A CZ  1 
ATOM   2149 O  OH  . TYR A 1 310 ? -20.567 -22.221 -19.412 1.00 45.28  ? 573  TYR A OH  1 
ATOM   2150 N  N   . GLN A 1 311 ? -15.314 -15.617 -17.101 1.00 50.60  ? 574  GLN A N   1 
ATOM   2151 C  CA  . GLN A 1 311 ? -14.151 -14.693 -17.051 1.00 50.55  ? 574  GLN A CA  1 
ATOM   2152 C  C   . GLN A 1 311 ? -14.067 -13.913 -15.724 1.00 53.58  ? 574  GLN A C   1 
ATOM   2153 O  O   . GLN A 1 311 ? -13.050 -13.208 -15.509 1.00 51.46  ? 574  GLN A O   1 
ATOM   2154 C  CB  . GLN A 1 311 ? -14.182 -13.771 -18.259 1.00 47.05  ? 574  GLN A CB  1 
ATOM   2155 C  CG  . GLN A 1 311 ? -13.952 -14.517 -19.559 1.00 44.14  ? 574  GLN A CG  1 
ATOM   2156 C  CD  . GLN A 1 311 ? -14.193 -13.608 -20.730 1.00 48.58  ? 574  GLN A CD  1 
ATOM   2157 O  OE1 . GLN A 1 311 ? -14.466 -12.433 -20.556 1.00 61.29  ? 574  GLN A OE1 1 
ATOM   2158 N  NE2 . GLN A 1 311 ? -14.108 -14.143 -21.935 1.00 54.88  ? 574  GLN A NE2 1 
ATOM   2159 N  N   . ASN A 1 312 ? -15.083 -14.032 -14.856 0.34 54.14  ? 575  ASN A N   1 
ATOM   2160 C  CA  . ASN A 1 312 ? -15.157 -13.346 -13.533 0.34 55.25  ? 575  ASN A CA  1 
ATOM   2161 C  C   . ASN A 1 312 ? -15.989 -14.193 -12.561 0.34 55.65  ? 575  ASN A C   1 
ATOM   2162 O  O   . ASN A 1 312 ? -17.146 -13.820 -12.295 0.34 56.93  ? 575  ASN A O   1 
ATOM   2163 C  CB  . ASN A 1 312 ? -15.759 -11.941 -13.649 0.34 54.18  ? 575  ASN A CB  1 
ATOM   2164 C  CG  . ASN A 1 312 ? -14.888 -10.977 -14.426 0.34 55.30  ? 575  ASN A CG  1 
ATOM   2165 O  OD1 . ASN A 1 312 ? -13.877 -10.496 -13.918 0.34 57.50  ? 575  ASN A OD1 1 
ATOM   2166 N  ND2 . ASN A 1 312 ? -15.274 -10.681 -15.657 0.34 54.04  ? 575  ASN A ND2 1 
ATOM   2167 N  N   . LYS A 1 313 ? -15.407 -15.270 -12.028 0.34 56.38  ? 576  LYS A N   1 
ATOM   2168 C  CA  . LYS A 1 313 ? -16.119 -16.300 -11.225 0.34 57.56  ? 576  LYS A CA  1 
ATOM   2169 C  C   . LYS A 1 313 ? -16.339 -15.799 -9.792  0.34 57.83  ? 576  LYS A C   1 
ATOM   2170 O  O   . LYS A 1 313 ? -15.841 -14.709 -9.458  0.34 58.53  ? 576  LYS A O   1 
ATOM   2171 C  CB  . LYS A 1 313 ? -15.317 -17.605 -11.197 0.34 58.99  ? 576  LYS A CB  1 
ATOM   2172 C  CG  . LYS A 1 313 ? -14.732 -18.046 -12.532 0.34 59.30  ? 576  LYS A CG  1 
ATOM   2173 C  CD  . LYS A 1 313 ? -14.068 -19.406 -12.471 0.34 59.69  ? 576  LYS A CD  1 
ATOM   2174 C  CE  . LYS A 1 313 ? -13.378 -19.786 -13.763 0.34 59.57  ? 576  LYS A CE  1 
ATOM   2175 N  NZ  . LYS A 1 313 ? -12.602 -18.652 -14.313 0.34 60.29  ? 576  LYS A NZ  1 
ATOM   2176 N  N   . VAL A 1 314 ? -17.064 -16.589 -8.994  0.34 56.99  ? 577  VAL A N   1 
ATOM   2177 C  CA  . VAL A 1 314 ? -17.297 -16.391 -7.533  0.34 56.52  ? 577  VAL A CA  1 
ATOM   2178 C  C   . VAL A 1 314 ? -17.659 -17.757 -6.947  0.34 56.66  ? 577  VAL A C   1 
ATOM   2179 O  O   . VAL A 1 314 ? -18.559 -18.407 -7.509  0.34 55.10  ? 577  VAL A O   1 
ATOM   2180 C  CB  . VAL A 1 314 ? -18.407 -15.359 -7.254  0.34 58.02  ? 577  VAL A CB  1 
ATOM   2181 C  CG1 . VAL A 1 314 ? -18.870 -15.412 -5.805  0.34 58.63  ? 577  VAL A CG1 1 
ATOM   2182 C  CG2 . VAL A 1 314 ? -17.980 -13.950 -7.630  0.34 57.51  ? 577  VAL A CG2 1 
ATOM   2183 N  N   . VAL A 1 315 ? -16.980 -18.168 -5.871  1.00 57.43  ? 578  VAL A N   1 
ATOM   2184 C  CA  . VAL A 1 315 ? -17.018 -19.569 -5.382  1.00 58.49  ? 578  VAL A CA  1 
ATOM   2185 C  C   . VAL A 1 315 ? -17.067 -19.550 -3.869  1.00 62.23  ? 578  VAL A C   1 
ATOM   2186 O  O   . VAL A 1 315 ? -16.410 -18.693 -3.253  1.00 58.94  ? 578  VAL A O   1 
ATOM   2187 C  CB  . VAL A 1 315 ? -15.761 -20.340 -5.832  1.00 61.33  ? 578  VAL A CB  1 
ATOM   2188 C  CG1 . VAL A 1 315 ? -15.947 -21.835 -5.659  1.00 65.71  ? 578  VAL A CG1 1 
ATOM   2189 C  CG2 . VAL A 1 315 ? -15.334 -19.999 -7.257  1.00 61.92  ? 578  VAL A CG2 1 
ATOM   2190 N  N   . ARG A 1 316 ? -17.814 -20.496 -3.293  0.34 62.30  ? 579  ARG A N   1 
ATOM   2191 C  CA  . ARG A 1 316 ? -17.924 -20.730 -1.830  0.34 66.24  ? 579  ARG A CA  1 
ATOM   2192 C  C   . ARG A 1 316 ? -17.331 -22.106 -1.504  0.34 69.38  ? 579  ARG A C   1 
ATOM   2193 O  O   . ARG A 1 316 ? -17.952 -23.121 -1.879  0.34 69.88  ? 579  ARG A O   1 
ATOM   2194 C  CB  . ARG A 1 316 ? -19.387 -20.633 -1.390  0.34 66.10  ? 579  ARG A CB  1 
ATOM   2195 C  CG  . ARG A 1 316 ? -20.260 -21.780 -1.876  0.34 66.62  ? 579  ARG A CG  1 
ATOM   2196 C  CD  . ARG A 1 316 ? -21.672 -21.688 -1.327  0.34 67.97  ? 579  ARG A CD  1 
ATOM   2197 N  NE  . ARG A 1 316 ? -22.403 -20.549 -1.865  0.34 67.95  ? 579  ARG A NE  1 
ATOM   2198 C  CZ  . ARG A 1 316 ? -23.697 -20.331 -1.671  0.34 67.12  ? 579  ARG A CZ  1 
ATOM   2199 N  NH1 . ARG A 1 316 ? -24.274 -19.263 -2.197  0.34 66.73  ? 579  ARG A NH1 1 
ATOM   2200 N  NH2 . ARG A 1 316 ? -24.410 -21.182 -0.955  0.34 66.13  ? 579  ARG A NH2 1 
ATOM   2201 N  N   . VAL A 1 317 ? -16.177 -22.128 -0.827  0.34 72.14  ? 580  VAL A N   1 
ATOM   2202 C  CA  . VAL A 1 317 ? -15.417 -23.365 -0.470  0.34 72.52  ? 580  VAL A CA  1 
ATOM   2203 C  C   . VAL A 1 317 ? -15.426 -23.533 1.053   0.34 74.78  ? 580  VAL A C   1 
ATOM   2204 O  O   . VAL A 1 317 ? -14.981 -22.600 1.746   0.34 71.01  ? 580  VAL A O   1 
ATOM   2205 C  CB  . VAL A 1 317 ? -13.976 -23.305 -1.009  0.34 71.86  ? 580  VAL A CB  1 
ATOM   2206 C  CG1 . VAL A 1 317 ? -13.295 -24.664 -0.945  0.34 72.15  ? 580  VAL A CG1 1 
ATOM   2207 C  CG2 . VAL A 1 317 ? -13.924 -22.743 -2.420  0.34 72.17  ? 580  VAL A CG2 1 
ATOM   2208 N  N   . GLN A 1 318 ? -15.907 -24.683 1.540   0.34 82.08  ? 581  GLN A N   1 
ATOM   2209 C  CA  . GLN A 1 318 ? -15.920 -25.050 2.983   0.34 86.97  ? 581  GLN A CA  1 
ATOM   2210 C  C   . GLN A 1 318 ? -14.493 -25.371 3.439   0.34 94.83  ? 581  GLN A C   1 
ATOM   2211 O  O   . GLN A 1 318 ? -13.839 -26.215 2.792   0.34 97.72  ? 581  GLN A O   1 
ATOM   2212 C  CB  . GLN A 1 318 ? -16.838 -26.248 3.237   0.34 85.55  ? 581  GLN A CB  1 
ATOM   2213 C  CG  . GLN A 1 318 ? -18.300 -25.867 3.410   0.34 86.20  ? 581  GLN A CG  1 
ATOM   2214 C  CD  . GLN A 1 318 ? -19.066 -26.882 4.222   0.34 85.84  ? 581  GLN A CD  1 
ATOM   2215 O  OE1 . GLN A 1 318 ? -18.615 -28.005 4.437   0.34 84.53  ? 581  GLN A OE1 1 
ATOM   2216 N  NE2 . GLN A 1 318 ? -20.242 -26.490 4.685   0.34 85.99  ? 581  GLN A NE2 1 
ATOM   2217 N  N   . ARG A 1 319 ? -14.043 -24.719 4.516   0.34 101.22 ? 582  ARG A N   1 
ATOM   2218 C  CA  . ARG A 1 319 ? -12.704 -24.914 5.135   0.34 106.59 ? 582  ARG A CA  1 
ATOM   2219 C  C   . ARG A 1 319 ? -12.895 -25.374 6.578   0.34 112.07 ? 582  ARG A C   1 
ATOM   2220 O  O   . ARG A 1 319 ? -13.197 -24.554 7.443   0.34 111.87 ? 582  ARG A O   1 
ATOM   2221 C  CB  . ARG A 1 319 ? -11.901 -23.611 5.066   0.34 107.01 ? 582  ARG A CB  1 
ATOM   2222 C  CG  . ARG A 1 319 ? -10.480 -23.716 5.603   0.34 106.52 ? 582  ARG A CG  1 
ATOM   2223 C  CD  . ARG A 1 319 ? -9.588  -22.607 5.076   0.34 107.43 ? 582  ARG A CD  1 
ATOM   2224 N  NE  . ARG A 1 319 ? -10.185 -21.286 5.224   0.34 108.00 ? 582  ARG A NE  1 
ATOM   2225 C  CZ  . ARG A 1 319 ? -9.770  -20.360 6.083   0.34 108.92 ? 582  ARG A CZ  1 
ATOM   2226 N  NH1 . ARG A 1 319 ? -8.743  -20.607 6.878   0.34 110.22 ? 582  ARG A NH1 1 
ATOM   2227 N  NH2 . ARG A 1 319 ? -10.378 -19.189 6.139   0.34 108.91 ? 582  ARG A NH2 1 
ATOM   2228 N  N   . PRO A 1 320 ? -12.734 -26.685 6.886   1.00 120.19 ? 583  PRO A N   1 
ATOM   2229 C  CA  . PRO A 1 320 ? -12.949 -27.189 8.253   1.00 123.13 ? 583  PRO A CA  1 
ATOM   2230 C  C   . PRO A 1 320 ? -12.356 -26.466 9.483   1.00 120.77 ? 583  PRO A C   1 
ATOM   2231 O  O   . PRO A 1 320 ? -12.863 -26.695 10.570  1.00 118.06 ? 583  PRO A O   1 
ATOM   2232 C  CB  . PRO A 1 320 ? -12.293 -28.581 8.182   1.00 124.45 ? 583  PRO A CB  1 
ATOM   2233 C  CG  . PRO A 1 320 ? -12.503 -29.020 6.752   1.00 124.78 ? 583  PRO A CG  1 
ATOM   2234 C  CD  . PRO A 1 320 ? -12.335 -27.750 5.945   1.00 125.31 ? 583  PRO A CD  1 
ATOM   2235 N  N   . THR A 1 321 ? -11.326 -25.631 9.314   1.00 115.53 ? 584  THR A N   1 
ATOM   2236 C  CA  . THR A 1 321 ? -10.734 -24.799 10.400  1.00 118.19 ? 584  THR A CA  1 
ATOM   2237 C  C   . THR A 1 321 ? -11.829 -23.942 11.051  1.00 112.87 ? 584  THR A C   1 
ATOM   2238 O  O   . THR A 1 321 ? -11.986 -24.044 12.283  1.00 112.85 ? 584  THR A O   1 
ATOM   2239 C  CB  . THR A 1 321 ? -9.614  -23.895 9.873   1.00 122.60 ? 584  THR A CB  1 
ATOM   2240 O  OG1 . THR A 1 321 ? -10.229 -22.917 9.038   1.00 130.14 ? 584  THR A OG1 1 
ATOM   2241 C  CG2 . THR A 1 321 ? -8.541  -24.637 9.106   1.00 122.81 ? 584  THR A CG2 1 
ATOM   2242 N  N   . THR A 1 325 ? -15.426 -24.593 10.880  0.34 69.37  ? 588  THR A N   1 
ATOM   2243 C  CA  . THR A 1 325 ? -15.798 -24.583 9.440   0.34 70.27  ? 588  THR A CA  1 
ATOM   2244 C  C   . THR A 1 325 ? -16.309 -23.188 9.057   0.34 68.39  ? 588  THR A C   1 
ATOM   2245 O  O   . THR A 1 325 ? -17.382 -22.790 9.557   0.34 66.07  ? 588  THR A O   1 
ATOM   2246 C  CB  . THR A 1 325 ? -16.831 -25.676 9.132   0.34 72.76  ? 588  THR A CB  1 
ATOM   2247 O  OG1 . THR A 1 325 ? -16.291 -26.928 9.556   0.34 76.59  ? 588  THR A OG1 1 
ATOM   2248 C  CG2 . THR A 1 325 ? -17.191 -25.758 7.665   0.34 74.18  ? 588  THR A CG2 1 
ATOM   2249 N  N   . VAL A 1 326 ? -15.563 -22.479 8.204   0.34 66.74  ? 589  VAL A N   1 
ATOM   2250 C  CA  . VAL A 1 326 ? -15.925 -21.126 7.685   0.34 66.85  ? 589  VAL A CA  1 
ATOM   2251 C  C   . VAL A 1 326 ? -15.968 -21.179 6.153   0.34 65.88  ? 589  VAL A C   1 
ATOM   2252 O  O   . VAL A 1 326 ? -14.938 -21.520 5.539   0.34 63.81  ? 589  VAL A O   1 
ATOM   2253 C  CB  . VAL A 1 326 ? -14.944 -20.048 8.184   0.34 67.26  ? 589  VAL A CB  1 
ATOM   2254 C  CG1 . VAL A 1 326 ? -14.446 -20.344 9.590   0.34 68.46  ? 589  VAL A CG1 1 
ATOM   2255 C  CG2 . VAL A 1 326 ? -13.774 -19.862 7.230   0.34 67.16  ? 589  VAL A CG2 1 
ATOM   2256 N  N   . MET A 1 327 ? -17.123 -20.852 5.566   0.34 65.94  ? 590  MET A N   1 
ATOM   2257 C  CA  . MET A 1 327 ? -17.345 -20.830 4.095   0.34 66.54  ? 590  MET A CA  1 
ATOM   2258 C  C   . MET A 1 327 ? -16.668 -19.591 3.501   0.34 63.96  ? 590  MET A C   1 
ATOM   2259 O  O   . MET A 1 327 ? -17.251 -18.499 3.606   0.34 63.75  ? 590  MET A O   1 
ATOM   2260 C  CB  . MET A 1 327 ? -18.841 -20.793 3.764   0.34 67.60  ? 590  MET A CB  1 
ATOM   2261 C  CG  . MET A 1 327 ? -19.129 -20.785 2.275   0.34 68.10  ? 590  MET A CG  1 
ATOM   2262 S  SD  . MET A 1 327 ? -18.784 -22.376 1.481   0.34 69.35  ? 590  MET A SD  1 
ATOM   2263 C  CE  . MET A 1 327 ? -20.126 -23.371 2.132   0.34 68.95  ? 590  MET A CE  1 
ATOM   2264 N  N   . ASP A 1 328 ? -15.487 -19.766 2.899   0.34 62.50  ? 591  ASP A N   1 
ATOM   2265 C  CA  . ASP A 1 328 ? -14.716 -18.683 2.229   0.34 60.98  ? 591  ASP A CA  1 
ATOM   2266 C  C   . ASP A 1 328 ? -15.418 -18.306 0.920   0.34 61.46  ? 591  ASP A C   1 
ATOM   2267 O  O   . ASP A 1 328 ? -15.789 -19.223 0.158   0.34 61.77  ? 591  ASP A O   1 
ATOM   2268 C  CB  . ASP A 1 328 ? -13.264 -19.098 1.980   0.34 59.62  ? 591  ASP A CB  1 
ATOM   2269 C  CG  . ASP A 1 328 ? -12.406 -19.120 3.235   0.34 58.11  ? 591  ASP A CG  1 
ATOM   2270 O  OD1 . ASP A 1 328 ? -12.287 -18.059 3.882   0.34 54.06  ? 591  ASP A OD1 1 
ATOM   2271 O  OD2 . ASP A 1 328 ? -11.863 -20.198 3.553   0.34 56.75  ? 591  ASP A OD2 1 
ATOM   2272 N  N   . ILE A 1 329 ? -15.604 -17.004 0.686   0.34 60.41  ? 592  ILE A N   1 
ATOM   2273 C  CA  . ILE A 1 329 ? -16.171 -16.445 -0.575  0.34 59.94  ? 592  ILE A CA  1 
ATOM   2274 C  C   . ILE A 1 329 ? -15.005 -15.959 -1.434  0.34 60.97  ? 592  ILE A C   1 
ATOM   2275 O  O   . ILE A 1 329 ? -14.645 -14.767 -1.344  0.34 59.42  ? 592  ILE A O   1 
ATOM   2276 C  CB  . ILE A 1 329 ? -17.193 -15.327 -0.292  0.34 60.33  ? 592  ILE A CB  1 
ATOM   2277 C  CG1 . ILE A 1 329 ? -18.439 -15.876 0.406   0.34 59.86  ? 592  ILE A CG1 1 
ATOM   2278 C  CG2 . ILE A 1 329 ? -17.543 -14.584 -1.571  0.34 59.70  ? 592  ILE A CG2 1 
ATOM   2279 C  CD1 . ILE A 1 329 ? -18.896 -17.213 -0.123  0.34 59.59  ? 592  ILE A CD1 1 
ATOM   2280 N  N   . ILE A 1 330 ? -14.443 -16.870 -2.230  0.34 63.11  ? 593  ILE A N   1 
ATOM   2281 C  CA  . ILE A 1 330 ? -13.215 -16.644 -3.045  0.34 64.43  ? 593  ILE A CA  1 
ATOM   2282 C  C   . ILE A 1 330 ? -13.628 -16.402 -4.501  0.34 63.57  ? 593  ILE A C   1 
ATOM   2283 O  O   . ILE A 1 330 ? -14.673 -16.939 -4.919  0.34 63.49  ? 593  ILE A O   1 
ATOM   2284 C  CB  . ILE A 1 330 ? -12.257 -17.841 -2.896  0.34 64.54  ? 593  ILE A CB  1 
ATOM   2285 C  CG1 . ILE A 1 330 ? -12.911 -19.148 -3.354  0.34 64.09  ? 593  ILE A CG1 1 
ATOM   2286 C  CG2 . ILE A 1 330 ? -11.749 -17.938 -1.465  0.34 64.83  ? 593  ILE A CG2 1 
ATOM   2287 C  CD1 . ILE A 1 330 ? -12.022 -20.362 -3.217  0.34 64.00  ? 593  ILE A CD1 1 
ATOM   2288 N  N   . SER A 1 331 ? -12.831 -15.615 -5.228  0.34 62.62  ? 594  SER A N   1 
ATOM   2289 C  CA  . SER A 1 331 ? -13.059 -15.231 -6.645  0.34 62.61  ? 594  SER A CA  1 
ATOM   2290 C  C   . SER A 1 331 ? -11.760 -15.395 -7.443  0.34 63.48  ? 594  SER A C   1 
ATOM   2291 O  O   . SER A 1 331 ? -10.693 -15.539 -6.814  0.34 64.60  ? 594  SER A O   1 
ATOM   2292 C  CB  . SER A 1 331 ? -13.581 -13.823 -6.732  0.34 61.72  ? 594  SER A CB  1 
ATOM   2293 O  OG  . SER A 1 331 ? -12.563 -12.887 -6.410  0.34 60.46  ? 594  SER A OG  1 
ATOM   2294 N  N   . ARG A 1 332 ? -11.863 -15.376 -8.775  0.34 63.05  ? 595  ARG A N   1 
ATOM   2295 C  CA  . ARG A 1 332 ? -10.721 -15.437 -9.728  0.34 63.31  ? 595  ARG A CA  1 
ATOM   2296 C  C   . ARG A 1 332 ? -11.272 -15.348 -11.153 0.34 62.99  ? 595  ARG A C   1 
ATOM   2297 O  O   . ARG A 1 332 ? -12.454 -15.700 -11.346 0.34 65.10  ? 595  ARG A O   1 
ATOM   2298 C  CB  . ARG A 1 332 ? -9.921  -16.732 -9.561  0.34 64.58  ? 595  ARG A CB  1 
ATOM   2299 C  CG  . ARG A 1 332 ? -10.382 -17.866 -10.465 0.34 64.19  ? 595  ARG A CG  1 
ATOM   2300 C  CD  . ARG A 1 332 ? -9.539  -19.117 -10.305 0.34 64.95  ? 595  ARG A CD  1 
ATOM   2301 N  NE  . ARG A 1 332 ? -8.218  -19.001 -10.911 0.34 63.91  ? 595  ARG A NE  1 
ATOM   2302 C  CZ  . ARG A 1 332 ? -7.106  -18.696 -10.250 0.34 63.07  ? 595  ARG A CZ  1 
ATOM   2303 N  NH1 . ARG A 1 332 ? -7.149  -18.464 -8.949  0.34 63.55  ? 595  ARG A NH1 1 
ATOM   2304 N  NH2 . ARG A 1 332 ? -5.955  -18.623 -10.893 0.34 61.68  ? 595  ARG A NH2 1 
ATOM   2305 N  N   . ARG A 1 333 ? -10.441 -14.911 -12.103 1.00 59.88  ? 596  ARG A N   1 
ATOM   2306 C  CA  . ARG A 1 333 ? -10.868 -14.661 -13.502 1.00 63.57  ? 596  ARG A CA  1 
ATOM   2307 C  C   . ARG A 1 333 ? -10.664 -15.908 -14.380 1.00 64.63  ? 596  ARG A C   1 
ATOM   2308 O  O   . ARG A 1 333 ? -11.553 -16.193 -15.211 1.00 58.86  ? 596  ARG A O   1 
ATOM   2309 C  CB  . ARG A 1 333 ? -10.107 -13.421 -13.976 1.00 65.54  ? 596  ARG A CB  1 
ATOM   2310 C  CG  . ARG A 1 333 ? -10.464 -12.186 -13.152 1.00 71.56  ? 596  ARG A CG  1 
ATOM   2311 C  CD  . ARG A 1 333 ? -10.390 -10.881 -13.931 1.00 77.45  ? 596  ARG A CD  1 
ATOM   2312 N  NE  . ARG A 1 333 ? -11.138 -10.958 -15.187 1.00 82.66  ? 596  ARG A NE  1 
ATOM   2313 C  CZ  . ARG A 1 333 ? -10.839 -10.290 -16.306 1.00 92.51  ? 596  ARG A CZ  1 
ATOM   2314 N  NH1 . ARG A 1 333 ? -9.808  -9.456  -16.344 1.00 95.15  ? 596  ARG A NH1 1 
ATOM   2315 N  NH2 . ARG A 1 333 ? -11.580 -10.464 -17.390 1.00 89.90  ? 596  ARG A NH2 1 
ATOM   2316 N  N   . ASP A 1 334 ? -9.568  -16.643 -14.176 1.00 58.03  ? 597  ASP A N   1 
ATOM   2317 C  CA  . ASP A 1 334 ? -9.057  -17.682 -15.115 1.00 59.72  ? 597  ASP A CA  1 
ATOM   2318 C  C   . ASP A 1 334 ? -9.404  -19.082 -14.568 1.00 54.15  ? 597  ASP A C   1 
ATOM   2319 O  O   . ASP A 1 334 ? -10.153 -19.170 -13.568 1.00 52.85  ? 597  ASP A O   1 
ATOM   2320 C  CB  . ASP A 1 334 ? -7.575  -17.426 -15.429 1.00 59.24  ? 597  ASP A CB  1 
ATOM   2321 C  CG  . ASP A 1 334 ? -6.608  -17.839 -14.331 1.00 61.69  ? 597  ASP A CG  1 
ATOM   2322 O  OD1 . ASP A 1 334 ? -7.068  -18.114 -13.215 1.00 59.65  ? 597  ASP A OD1 1 
ATOM   2323 O  OD2 . ASP A 1 334 ? -5.394  -17.918 -14.620 1.00 76.36  ? 597  ASP A OD2 1 
ATOM   2324 N  N   . GLN A 1 335 ? -8.874  -20.129 -15.216 0.34 54.50  ? 598  GLN A N   1 
ATOM   2325 C  CA  . GLN A 1 335 ? -9.143  -21.570 -14.940 0.34 54.29  ? 598  GLN A CA  1 
ATOM   2326 C  C   . GLN A 1 335 ? -10.550 -21.927 -15.429 0.34 54.72  ? 598  GLN A C   1 
ATOM   2327 O  O   . GLN A 1 335 ? -11.337 -21.004 -15.716 0.34 53.43  ? 598  GLN A O   1 
ATOM   2328 C  CB  . GLN A 1 335 ? -8.982  -21.912 -13.457 0.34 54.26  ? 598  GLN A CB  1 
ATOM   2329 C  CG  . GLN A 1 335 ? -7.568  -21.697 -12.936 0.34 54.53  ? 598  GLN A CG  1 
ATOM   2330 C  CD  . GLN A 1 335 ? -7.436  -22.049 -11.474 0.34 54.48  ? 598  GLN A CD  1 
ATOM   2331 O  OE1 . GLN A 1 335 ? -8.419  -22.314 -10.786 0.34 55.53  ? 598  GLN A OE1 1 
ATOM   2332 N  NE2 . GLN A 1 335 ? -6.208  -22.053 -10.988 0.34 55.23  ? 598  GLN A NE2 1 
ATOM   2333 N  N   . ARG A 1 336 ? -10.844 -23.227 -15.519 0.34 56.81  ? 599  ARG A N   1 
ATOM   2334 C  CA  . ARG A 1 336 ? -12.126 -23.755 -16.050 0.34 58.33  ? 599  ARG A CA  1 
ATOM   2335 C  C   . ARG A 1 336 ? -13.142 -23.898 -14.915 0.34 61.06  ? 599  ARG A C   1 
ATOM   2336 O  O   . ARG A 1 336 ? -12.917 -24.716 -13.997 0.34 59.82  ? 599  ARG A O   1 
ATOM   2337 C  CB  . ARG A 1 336 ? -11.934 -25.108 -16.738 0.34 57.58  ? 599  ARG A CB  1 
ATOM   2338 C  CG  . ARG A 1 336 ? -13.234 -25.715 -17.245 0.34 56.08  ? 599  ARG A CG  1 
ATOM   2339 C  CD  . ARG A 1 336 ? -13.769 -24.959 -18.444 0.34 53.97  ? 599  ARG A CD  1 
ATOM   2340 N  NE  . ARG A 1 336 ? -12.949 -25.220 -19.614 0.34 52.30  ? 599  ARG A NE  1 
ATOM   2341 C  CZ  . ARG A 1 336 ? -12.819 -24.393 -20.640 0.34 51.40  ? 599  ARG A CZ  1 
ATOM   2342 N  NH1 . ARG A 1 336 ? -13.461 -23.238 -20.642 0.34 50.16  ? 599  ARG A NH1 1 
ATOM   2343 N  NH2 . ARG A 1 336 ? -12.046 -24.727 -21.657 0.34 51.28  ? 599  ARG A NH2 1 
ATOM   2344 N  N   . GLY A 1 337 ? -14.225 -23.125 -15.006 0.34 64.91  ? 600  GLY A N   1 
ATOM   2345 C  CA  . GLY A 1 337 ? -15.414 -23.224 -14.144 0.34 67.15  ? 600  GLY A CA  1 
ATOM   2346 C  C   . GLY A 1 337 ? -16.671 -23.118 -14.985 0.34 69.99  ? 600  GLY A C   1 
ATOM   2347 O  O   . GLY A 1 337 ? -16.969 -22.002 -15.466 0.34 69.98  ? 600  GLY A O   1 
ATOM   2348 N  N   . SER A 1 338 ? -17.347 -24.250 -15.201 0.34 71.16  ? 601  SER A N   1 
ATOM   2349 C  CA  . SER A 1 338 ? -18.616 -24.357 -15.963 0.34 71.14  ? 601  SER A CA  1 
ATOM   2350 C  C   . SER A 1 338 ? -19.304 -25.678 -15.609 0.34 71.95  ? 601  SER A C   1 
ATOM   2351 O  O   . SER A 1 338 ? -18.767 -26.419 -14.764 0.34 71.16  ? 601  SER A O   1 
ATOM   2352 C  CB  . SER A 1 338 ? -18.375 -24.254 -17.451 0.34 71.24  ? 601  SER A CB  1 
ATOM   2353 O  OG  . SER A 1 338 ? -17.326 -23.342 -17.738 0.34 70.79  ? 601  SER A OG  1 
ATOM   2354 N  N   . GLY A 1 339 ? -20.448 -25.942 -16.245 1.00 74.92  ? 602  GLY A N   1 
ATOM   2355 C  CA  . GLY A 1 339 ? -21.143 -27.238 -16.174 1.00 76.99  ? 602  GLY A CA  1 
ATOM   2356 C  C   . GLY A 1 339 ? -20.259 -28.280 -16.825 1.00 69.13  ? 602  GLY A C   1 
ATOM   2357 O  O   . GLY A 1 339 ? -19.453 -27.887 -17.691 1.00 51.58  ? 602  GLY A O   1 
ATOM   2358 N  N   . GLN A 1 340 ? -20.342 -29.534 -16.384 1.00 67.10  ? 603  GLN A N   1 
ATOM   2359 C  CA  . GLN A 1 340 ? -19.433 -30.586 -16.890 1.00 70.41  ? 603  GLN A CA  1 
ATOM   2360 C  C   . GLN A 1 340 ? -19.601 -30.639 -18.413 1.00 60.30  ? 603  GLN A C   1 
ATOM   2361 O  O   . GLN A 1 340 ? -18.596 -30.806 -19.095 1.00 59.92  ? 603  GLN A O   1 
ATOM   2362 C  CB  . GLN A 1 340 ? -19.650 -31.918 -16.160 1.00 86.09  ? 603  GLN A CB  1 
ATOM   2363 C  CG  . GLN A 1 340 ? -21.031 -32.536 -16.351 1.00 105.28 ? 603  GLN A CG  1 
ATOM   2364 C  CD  . GLN A 1 340 ? -21.003 -34.049 -16.394 1.00 119.91 ? 603  GLN A CD  1 
ATOM   2365 O  OE1 . GLN A 1 340 ? -21.213 -34.720 -15.385 1.00 129.80 ? 603  GLN A OE1 1 
ATOM   2366 N  NE2 . GLN A 1 340 ? -20.754 -34.608 -17.571 1.00 123.58 ? 603  GLN A NE2 1 
ATOM   2367 N  N   . VAL A 1 341 ? -20.809 -30.425 -18.941 1.00 57.30  ? 604  VAL A N   1 
ATOM   2368 C  CA  . VAL A 1 341 ? -21.101 -30.666 -20.388 1.00 53.03  ? 604  VAL A CA  1 
ATOM   2369 C  C   . VAL A 1 341 ? -20.575 -29.513 -21.245 1.00 50.23  ? 604  VAL A C   1 
ATOM   2370 O  O   . VAL A 1 341 ? -20.068 -29.788 -22.351 1.00 45.08  ? 604  VAL A O   1 
ATOM   2371 C  CB  . VAL A 1 341 ? -22.595 -30.900 -20.649 1.00 53.06  ? 604  VAL A CB  1 
ATOM   2372 C  CG1 . VAL A 1 341 ? -22.882 -30.846 -22.142 1.00 59.27  ? 604  VAL A CG1 1 
ATOM   2373 C  CG2 . VAL A 1 341 ? -23.071 -32.214 -20.045 1.00 52.36  ? 604  VAL A CG2 1 
ATOM   2374 N  N   . VAL A 1 342 ? -20.724 -28.260 -20.811 1.00 46.61  ? 605  VAL A N   1 
ATOM   2375 C  CA  . VAL A 1 342 ? -20.116 -27.126 -21.570 1.00 43.97  ? 605  VAL A CA  1 
ATOM   2376 C  C   . VAL A 1 342 ? -18.594 -27.175 -21.406 1.00 38.86  ? 605  VAL A C   1 
ATOM   2377 O  O   . VAL A 1 342 ? -17.882 -26.829 -22.355 1.00 40.91  ? 605  VAL A O   1 
ATOM   2378 C  CB  . VAL A 1 342 ? -20.742 -25.783 -21.160 1.00 46.01  ? 605  VAL A CB  1 
ATOM   2379 C  CG1 . VAL A 1 342 ? -19.926 -24.584 -21.600 1.00 49.14  ? 605  VAL A CG1 1 
ATOM   2380 C  CG2 . VAL A 1 342 ? -22.147 -25.687 -21.719 1.00 51.11  ? 605  VAL A CG2 1 
ATOM   2381 N  N   . THR A 1 343 ? -18.096 -27.600 -20.250 1.00 35.08  ? 606  THR A N   1 
ATOM   2382 C  CA  . THR A 1 343 ? -16.647 -27.814 -20.026 1.00 38.60  ? 606  THR A CA  1 
ATOM   2383 C  C   . THR A 1 343 ? -16.091 -28.795 -21.070 1.00 35.37  ? 606  THR A C   1 
ATOM   2384 O  O   . THR A 1 343 ? -15.010 -28.542 -21.586 1.00 38.25  ? 606  THR A O   1 
ATOM   2385 C  CB  . THR A 1 343 ? -16.390 -28.315 -18.606 1.00 39.49  ? 606  THR A CB  1 
ATOM   2386 O  OG1 . THR A 1 343 ? -16.785 -27.233 -17.769 1.00 38.68  ? 606  THR A OG1 1 
ATOM   2387 C  CG2 . THR A 1 343 ? -14.939 -28.675 -18.375 1.00 38.74  ? 606  THR A CG2 1 
ATOM   2388 N  N   . TYR A 1 344 ? -16.819 -29.872 -21.373 1.00 32.72  ? 607  TYR A N   1 
ATOM   2389 C  CA  . TYR A 1 344 ? -16.383 -30.885 -22.347 1.00 31.44  ? 607  TYR A CA  1 
ATOM   2390 C  C   . TYR A 1 344 ? -16.184 -30.180 -23.688 1.00 33.50  ? 607  TYR A C   1 
ATOM   2391 O  O   . TYR A 1 344 ? -15.104 -30.347 -24.307 1.00 33.33  ? 607  TYR A O   1 
ATOM   2392 C  CB  . TYR A 1 344 ? -17.365 -32.051 -22.423 1.00 33.04  ? 607  TYR A CB  1 
ATOM   2393 C  CG  . TYR A 1 344 ? -16.984 -33.071 -23.468 1.00 33.07  ? 607  TYR A CG  1 
ATOM   2394 C  CD1 . TYR A 1 344 ? -16.050 -34.055 -23.194 1.00 33.27  ? 607  TYR A CD1 1 
ATOM   2395 C  CD2 . TYR A 1 344 ? -17.474 -32.994 -24.760 1.00 32.30  ? 607  TYR A CD2 1 
ATOM   2396 C  CE1 . TYR A 1 344 ? -15.670 -34.977 -24.151 1.00 31.51  ? 607  TYR A CE1 1 
ATOM   2397 C  CE2 . TYR A 1 344 ? -17.102 -33.906 -25.730 1.00 34.24  ? 607  TYR A CE2 1 
ATOM   2398 C  CZ  . TYR A 1 344 ? -16.197 -34.913 -25.427 1.00 36.04  ? 607  TYR A CZ  1 
ATOM   2399 O  OH  . TYR A 1 344 ? -15.794 -35.817 -26.384 1.00 37.96  ? 607  TYR A OH  1 
ATOM   2400 N  N   . GLY A 1 345 ? -17.183 -29.398 -24.120 1.00 30.93  ? 608  GLY A N   1 
ATOM   2401 C  CA  . GLY A 1 345 ? -17.176 -28.791 -25.466 1.00 29.68  ? 608  GLY A CA  1 
ATOM   2402 C  C   . GLY A 1 345 ? -16.077 -27.754 -25.618 1.00 29.44  ? 608  GLY A C   1 
ATOM   2403 O  O   . GLY A 1 345 ? -15.433 -27.742 -26.659 1.00 33.05  ? 608  GLY A O   1 
ATOM   2404 N  N   . LEU A 1 346 ? -15.883 -26.907 -24.612 1.00 28.69  ? 609  LEU A N   1 
ATOM   2405 C  CA  . LEU A 1 346 ? -14.881 -25.822 -24.646 1.00 34.26  ? 609  LEU A CA  1 
ATOM   2406 C  C   . LEU A 1 346 ? -13.476 -26.422 -24.472 1.00 33.55  ? 609  LEU A C   1 
ATOM   2407 O  O   . LEU A 1 346 ? -12.539 -25.912 -25.146 1.00 32.50  ? 609  LEU A O   1 
ATOM   2408 C  CB  . LEU A 1 346 ? -15.212 -24.771 -23.569 1.00 33.89  ? 609  LEU A CB  1 
ATOM   2409 C  CG  . LEU A 1 346 ? -16.517 -24.005 -23.797 1.00 35.90  ? 609  LEU A CG  1 
ATOM   2410 C  CD1 . LEU A 1 346 ? -16.672 -22.871 -22.786 1.00 38.34  ? 609  LEU A CD1 1 
ATOM   2411 C  CD2 . LEU A 1 346 ? -16.592 -23.448 -25.206 1.00 37.01  ? 609  LEU A CD2 1 
ATOM   2412 N  N   . ASN A 1 347 ? -13.340 -27.459 -23.636 1.00 31.43  ? 610  ASN A N   1 
ATOM   2413 C  CA  . ASN A 1 347 ? -12.092 -28.265 -23.532 1.00 30.54  ? 610  ASN A CA  1 
ATOM   2414 C  C   . ASN A 1 347 ? -11.737 -28.831 -24.912 1.00 29.57  ? 610  ASN A C   1 
ATOM   2415 O  O   . ASN A 1 347 ? -10.632 -28.616 -25.342 1.00 29.98  ? 610  ASN A O   1 
ATOM   2416 C  CB  . ASN A 1 347 ? -12.184 -29.331 -22.446 1.00 26.28  ? 610  ASN A CB  1 
ATOM   2417 C  CG  . ASN A 1 347 ? -12.038 -28.727 -21.073 1.00 30.35  ? 610  ASN A CG  1 
ATOM   2418 O  OD1 . ASN A 1 347 ? -11.656 -27.573 -20.924 1.00 29.38  ? 610  ASN A OD1 1 
ATOM   2419 N  ND2 . ASN A 1 347 ? -12.229 -29.529 -20.046 1.00 38.28  ? 610  ASN A ND2 1 
ATOM   2420 N  N   . THR A 1 348 ? -12.661 -29.479 -25.607 1.00 31.80  ? 611  THR A N   1 
ATOM   2421 C  CA  . THR A 1 348 ? -12.407 -30.050 -26.953 1.00 30.62  ? 611  THR A CA  1 
ATOM   2422 C  C   . THR A 1 348 ? -11.923 -28.921 -27.877 1.00 34.60  ? 611  THR A C   1 
ATOM   2423 O  O   . THR A 1 348 ? -10.932 -29.128 -28.615 1.00 31.47  ? 611  THR A O   1 
ATOM   2424 C  CB  . THR A 1 348 ? -13.655 -30.740 -27.499 1.00 29.18  ? 611  THR A CB  1 
ATOM   2425 O  OG1 . THR A 1 348 ? -14.091 -31.736 -26.572 1.00 29.45  ? 611  THR A OG1 1 
ATOM   2426 C  CG2 . THR A 1 348 ? -13.438 -31.354 -28.859 1.00 27.50  ? 611  THR A CG2 1 
ATOM   2427 N  N   . PHE A 1 349 ? -12.629 -27.786 -27.863 1.00 35.42  ? 612  PHE A N   1 
ATOM   2428 C  CA  . PHE A 1 349 ? -12.363 -26.636 -28.761 1.00 34.28  ? 612  PHE A CA  1 
ATOM   2429 C  C   . PHE A 1 349 ? -10.922 -26.157 -28.548 1.00 32.24  ? 612  PHE A C   1 
ATOM   2430 O  O   . PHE A 1 349 ? -10.200 -26.040 -29.505 1.00 29.24  ? 612  PHE A O   1 
ATOM   2431 C  CB  . PHE A 1 349 ? -13.307 -25.478 -28.477 1.00 34.94  ? 612  PHE A CB  1 
ATOM   2432 C  CG  . PHE A 1 349 ? -13.033 -24.295 -29.364 1.00 34.37  ? 612  PHE A CG  1 
ATOM   2433 C  CD1 . PHE A 1 349 ? -13.526 -24.261 -30.656 1.00 36.60  ? 612  PHE A CD1 1 
ATOM   2434 C  CD2 . PHE A 1 349 ? -12.270 -23.235 -28.916 1.00 32.06  ? 612  PHE A CD2 1 
ATOM   2435 C  CE1 . PHE A 1 349 ? -13.253 -23.184 -31.489 1.00 37.94  ? 612  PHE A CE1 1 
ATOM   2436 C  CE2 . PHE A 1 349 ? -11.999 -22.162 -29.748 1.00 33.65  ? 612  PHE A CE2 1 
ATOM   2437 C  CZ  . PHE A 1 349 ? -12.477 -22.138 -31.033 1.00 34.04  ? 612  PHE A CZ  1 
ATOM   2438 N  N   . THR A 1 350 ? -10.556 -25.890 -27.301 1.00 32.92  ? 613  THR A N   1 
ATOM   2439 C  CA  . THR A 1 350 ? -9.284  -25.254 -26.933 1.00 36.99  ? 613  THR A CA  1 
ATOM   2440 C  C   . THR A 1 350 ? -8.170  -26.273 -27.174 1.00 35.95  ? 613  THR A C   1 
ATOM   2441 O  O   . THR A 1 350 ? -7.134  -25.852 -27.684 1.00 40.23  ? 613  THR A O   1 
ATOM   2442 C  CB  . THR A 1 350 ? -9.338  -24.658 -25.526 1.00 36.57  ? 613  THR A CB  1 
ATOM   2443 O  OG1 . THR A 1 350 ? -10.301 -23.610 -25.602 1.00 34.89  ? 613  THR A OG1 1 
ATOM   2444 C  CG2 . THR A 1 350 ? -7.997  -24.092 -25.088 1.00 37.90  ? 613  THR A CG2 1 
ATOM   2445 N  N   . ASN A 1 351 ? -8.429  -27.561 -26.918 1.00 34.97  ? 614  ASN A N   1 
ATOM   2446 C  CA  . ASN A 1 351 ? -7.477  -28.668 -27.188 1.00 34.48  ? 614  ASN A CA  1 
ATOM   2447 C  C   . ASN A 1 351 ? -7.253  -28.768 -28.698 1.00 33.47  ? 614  ASN A C   1 
ATOM   2448 O  O   . ASN A 1 351 ? -6.100  -28.885 -29.108 1.00 28.99  ? 614  ASN A O   1 
ATOM   2449 C  CB  . ASN A 1 351 ? -7.930  -30.012 -26.603 1.00 32.69  ? 614  ASN A CB  1 
ATOM   2450 C  CG  . ASN A 1 351 ? -6.772  -30.935 -26.244 1.00 35.42  ? 614  ASN A CG  1 
ATOM   2451 O  OD1 . ASN A 1 351 ? -5.606  -30.586 -26.461 1.00 31.75  ? 614  ASN A OD1 1 
ATOM   2452 N  ND2 . ASN A 1 351 ? -7.079  -32.094 -25.662 1.00 33.85  ? 614  ASN A ND2 1 
ATOM   2453 N  N   . MET A 1 352 ? -8.315  -28.747 -29.497 1.00 30.99  ? 615  MET A N   1 
ATOM   2454 C  CA  . MET A 1 352 ? -8.169  -28.761 -30.972 1.00 35.38  ? 615  MET A CA  1 
ATOM   2455 C  C   . MET A 1 352 ? -7.252  -27.591 -31.392 1.00 33.43  ? 615  MET A C   1 
ATOM   2456 O  O   . MET A 1 352 ? -6.391  -27.793 -32.258 1.00 36.95  ? 615  MET A O   1 
ATOM   2457 C  CB  . MET A 1 352 ? -9.516  -28.646 -31.695 1.00 32.46  ? 615  MET A CB  1 
ATOM   2458 C  CG  . MET A 1 352 ? -10.373 -29.882 -31.636 1.00 33.06  ? 615  MET A CG  1 
ATOM   2459 S  SD  . MET A 1 352 ? -12.068 -29.617 -32.323 1.00 37.21  ? 615  MET A SD  1 
ATOM   2460 C  CE  . MET A 1 352 ? -11.715 -29.310 -34.045 1.00 35.01  ? 615  MET A CE  1 
ATOM   2461 N  N   . GLU A 1 353 ? -7.418  -26.425 -30.780 1.00 31.95  ? 616  GLU A N   1 
ATOM   2462 C  CA  . GLU A 1 353 ? -6.660  -25.197 -31.136 1.00 35.17  ? 616  GLU A CA  1 
ATOM   2463 C  C   . GLU A 1 353 ? -5.164  -25.419 -30.822 1.00 33.64  ? 616  GLU A C   1 
ATOM   2464 O  O   . GLU A 1 353 ? -4.306  -25.252 -31.711 1.00 34.31  ? 616  GLU A O   1 
ATOM   2465 C  CB  . GLU A 1 353 ? -7.286  -24.049 -30.353 1.00 34.24  ? 616  GLU A CB  1 
ATOM   2466 C  CG  . GLU A 1 353 ? -6.782  -22.662 -30.701 1.00 39.67  ? 616  GLU A CG  1 
ATOM   2467 C  CD  . GLU A 1 353 ? -6.978  -21.678 -29.549 1.00 41.96  ? 616  GLU A CD  1 
ATOM   2468 O  OE1 . GLU A 1 353 ? -8.160  -21.236 -29.307 1.00 41.78  ? 616  GLU A OE1 1 
ATOM   2469 O  OE2 . GLU A 1 353 ? -5.976  -21.434 -28.828 1.00 40.75  ? 616  GLU A OE2 1 
ATOM   2470 N  N   . ALA A 1 354 ? -4.867  -25.819 -29.597 1.00 32.55  ? 617  ALA A N   1 
ATOM   2471 C  CA  . ALA A 1 354 ? -3.501  -26.078 -29.109 1.00 32.62  ? 617  ALA A CA  1 
ATOM   2472 C  C   . ALA A 1 354 ? -2.816  -27.113 -30.002 1.00 36.77  ? 617  ALA A C   1 
ATOM   2473 O  O   . ALA A 1 354 ? -1.652  -26.893 -30.373 1.00 35.40  ? 617  ALA A O   1 
ATOM   2474 C  CB  . ALA A 1 354 ? -3.574  -26.515 -27.682 1.00 34.27  ? 617  ALA A CB  1 
ATOM   2475 N  N   . GLN A 1 355 ? -3.510  -28.190 -30.372 1.00 34.63  ? 618  GLN A N   1 
ATOM   2476 C  CA  . GLN A 1 355 ? -2.860  -29.265 -31.146 1.00 33.97  ? 618  GLN A CA  1 
ATOM   2477 C  C   . GLN A 1 355 ? -2.628  -28.833 -32.606 1.00 32.36  ? 618  GLN A C   1 
ATOM   2478 O  O   . GLN A 1 355 ? -1.656  -29.343 -33.189 1.00 33.16  ? 618  GLN A O   1 
ATOM   2479 C  CB  . GLN A 1 355 ? -3.614  -30.587 -31.013 1.00 32.10  ? 618  GLN A CB  1 
ATOM   2480 C  CG  . GLN A 1 355 ? -3.885  -31.022 -29.586 1.00 31.77  ? 618  GLN A CG  1 
ATOM   2481 C  CD  . GLN A 1 355 ? -2.613  -31.269 -28.829 1.00 34.62  ? 618  GLN A CD  1 
ATOM   2482 O  OE1 . GLN A 1 355 ? -1.611  -31.741 -29.364 1.00 33.77  ? 618  GLN A OE1 1 
ATOM   2483 N  NE2 . GLN A 1 355 ? -2.670  -30.993 -27.549 1.00 34.64  ? 618  GLN A NE2 1 
ATOM   2484 N  N   . LEU A 1 356 ? -3.503  -28.048 -33.239 1.00 31.81  ? 619  LEU A N   1 
ATOM   2485 C  CA  . LEU A 1 356 ? -3.246  -27.503 -34.617 1.00 33.37  ? 619  LEU A CA  1 
ATOM   2486 C  C   . LEU A 1 356 ? -1.993  -26.600 -34.576 1.00 33.30  ? 619  LEU A C   1 
ATOM   2487 O  O   . LEU A 1 356 ? -1.201  -26.663 -35.503 1.00 33.53  ? 619  LEU A O   1 
ATOM   2488 C  CB  . LEU A 1 356 ? -4.418  -26.658 -35.125 1.00 34.65  ? 619  LEU A CB  1 
ATOM   2489 C  CG  . LEU A 1 356 ? -5.517  -27.355 -35.913 1.00 37.90  ? 619  LEU A CG  1 
ATOM   2490 C  CD1 . LEU A 1 356 ? -6.588  -26.346 -36.272 1.00 41.80  ? 619  LEU A CD1 1 
ATOM   2491 C  CD2 . LEU A 1 356 ? -4.996  -28.032 -37.168 1.00 40.27  ? 619  LEU A CD2 1 
ATOM   2492 N  N   . ILE A 1 357 ? -1.832  -25.818 -33.513 1.00 31.56  ? 620  ILE A N   1 
ATOM   2493 C  CA  . ILE A 1 357 ? -0.697  -24.882 -33.313 1.00 35.84  ? 620  ILE A CA  1 
ATOM   2494 C  C   . ILE A 1 357 ? 0.581   -25.702 -33.095 1.00 41.96  ? 620  ILE A C   1 
ATOM   2495 O  O   . ILE A 1 357 ? 1.560   -25.426 -33.803 1.00 41.18  ? 620  ILE A O   1 
ATOM   2496 C  CB  . ILE A 1 357 ? -1.002  -23.891 -32.175 1.00 39.12  ? 620  ILE A CB  1 
ATOM   2497 C  CG1 . ILE A 1 357 ? -2.173  -22.980 -32.566 1.00 39.96  ? 620  ILE A CG1 1 
ATOM   2498 C  CG2 . ILE A 1 357 ? 0.243   -23.084 -31.805 1.00 40.18  ? 620  ILE A CG2 1 
ATOM   2499 C  CD1 . ILE A 1 357 ? -2.684  -22.078 -31.465 1.00 41.72  ? 620  ILE A CD1 1 
ATOM   2500 N  N   . ARG A 1 358 ? 0.558   -26.719 -32.226 1.00 38.36  ? 621  ARG A N   1 
ATOM   2501 C  CA  . ARG A 1 358 ? 1.707   -27.636 -32.067 1.00 35.26  ? 621  ARG A CA  1 
ATOM   2502 C  C   . ARG A 1 358 ? 2.057   -28.295 -33.406 1.00 36.51  ? 621  ARG A C   1 
ATOM   2503 O  O   . ARG A 1 358 ? 3.270   -28.476 -33.691 1.00 40.04  ? 621  ARG A O   1 
ATOM   2504 C  CB  . ARG A 1 358 ? 1.460   -28.700 -30.999 1.00 36.47  ? 621  ARG A CB  1 
ATOM   2505 C  CG  . ARG A 1 358 ? 2.684   -29.577 -30.788 1.00 33.57  ? 621  ARG A CG  1 
ATOM   2506 C  CD  . ARG A 1 358 ? 2.629   -30.450 -29.554 1.00 33.08  ? 621  ARG A CD  1 
ATOM   2507 N  NE  . ARG A 1 358 ? 3.777   -31.343 -29.499 1.00 33.09  ? 621  ARG A NE  1 
ATOM   2508 C  CZ  . ARG A 1 358 ? 3.954   -32.337 -28.637 1.00 35.57  ? 621  ARG A CZ  1 
ATOM   2509 N  NH1 . ARG A 1 358 ? 3.038   -32.641 -27.740 1.00 32.26  ? 621  ARG A NH1 1 
ATOM   2510 N  NH2 . ARG A 1 358 ? 5.073   -33.044 -28.683 1.00 43.07  ? 621  ARG A NH2 1 
ATOM   2511 N  N   . GLN A 1 359 ? 1.072   -28.714 -34.186 1.00 34.85  ? 622  GLN A N   1 
ATOM   2512 C  CA  . GLN A 1 359 ? 1.324   -29.210 -35.565 1.00 34.41  ? 622  GLN A CA  1 
ATOM   2513 C  C   . GLN A 1 359 ? 1.979   -28.076 -36.397 1.00 41.81  ? 622  GLN A C   1 
ATOM   2514 O  O   . GLN A 1 359 ? 2.883   -28.371 -37.195 1.00 47.09  ? 622  GLN A O   1 
ATOM   2515 C  CB  . GLN A 1 359 ? 0.046   -29.726 -36.238 1.00 32.24  ? 622  GLN A CB  1 
ATOM   2516 C  CG  . GLN A 1 359 ? -0.460  -31.066 -35.739 1.00 33.38  ? 622  GLN A CG  1 
ATOM   2517 C  CD  . GLN A 1 359 ? -1.455  -31.713 -36.677 1.00 34.10  ? 622  GLN A CD  1 
ATOM   2518 O  OE1 . GLN A 1 359 ? -1.116  -32.232 -37.743 1.00 35.27  ? 622  GLN A OE1 1 
ATOM   2519 N  NE2 . GLN A 1 359 ? -2.719  -31.686 -36.292 1.00 34.54  ? 622  GLN A NE2 1 
ATOM   2520 N  N   . MET A 1 360 ? 1.535   -26.822 -36.282 1.00 42.85  ? 623  MET A N   1 
ATOM   2521 C  CA  . MET A 1 360 ? 2.118   -25.700 -37.075 1.00 46.87  ? 623  MET A CA  1 
ATOM   2522 C  C   . MET A 1 360 ? 3.623   -25.563 -36.751 1.00 42.46  ? 623  MET A C   1 
ATOM   2523 O  O   . MET A 1 360 ? 4.408   -25.492 -37.687 1.00 37.94  ? 623  MET A O   1 
ATOM   2524 C  CB  . MET A 1 360 ? 1.416   -24.371 -36.783 1.00 46.29  ? 623  MET A CB  1 
ATOM   2525 C  CG  . MET A 1 360 ? 0.165   -24.142 -37.598 1.00 47.98  ? 623  MET A CG  1 
ATOM   2526 S  SD  . MET A 1 360 ? -0.630  -22.713 -36.887 1.00 47.87  ? 623  MET A SD  1 
ATOM   2527 C  CE  . MET A 1 360 ? -2.363  -23.051 -37.189 1.00 50.02  ? 623  MET A CE  1 
ATOM   2528 N  N   . GLU A 1 361 ? 3.973   -25.544 -35.470 1.00 36.69  ? 624  GLU A N   1 
ATOM   2529 C  CA  . GLU A 1 361 ? 5.351   -25.436 -34.954 1.00 39.08  ? 624  GLU A CA  1 
ATOM   2530 C  C   . GLU A 1 361 ? 6.183   -26.581 -35.509 1.00 43.64  ? 624  GLU A C   1 
ATOM   2531 O  O   . GLU A 1 361 ? 7.287   -26.313 -35.945 1.00 44.07  ? 624  GLU A O   1 
ATOM   2532 C  CB  . GLU A 1 361 ? 5.355   -25.473 -33.429 1.00 41.20  ? 624  GLU A CB  1 
ATOM   2533 C  CG  . GLU A 1 361 ? 6.710   -25.125 -32.827 1.00 42.25  ? 624  GLU A CG  1 
ATOM   2534 C  CD  . GLU A 1 361 ? 6.699   -24.879 -31.329 1.00 43.17  ? 624  GLU A CD  1 
ATOM   2535 O  OE1 . GLU A 1 361 ? 7.768   -24.955 -30.703 1.00 49.35  ? 624  GLU A OE1 1 
ATOM   2536 O  OE2 . GLU A 1 361 ? 5.620   -24.590 -30.779 1.00 46.00  ? 624  GLU A OE2 1 
ATOM   2537 N  N   . GLY A 1 362 ? 5.674   -27.812 -35.488 1.00 39.71  ? 625  GLY A N   1 
ATOM   2538 C  CA  . GLY A 1 362 ? 6.408   -28.964 -36.029 1.00 41.90  ? 625  GLY A CA  1 
ATOM   2539 C  C   . GLY A 1 362 ? 6.694   -28.857 -37.531 1.00 43.25  ? 625  GLY A C   1 
ATOM   2540 O  O   . GLY A 1 362 ? 7.756   -29.358 -37.989 1.00 42.10  ? 625  GLY A O   1 
ATOM   2541 N  N   . GLU A 1 363 ? 5.776   -28.248 -38.289 0.34 41.44  ? 626  GLU A N   1 
ATOM   2542 C  CA  . GLU A 1 363 ? 5.888   -28.098 -39.765 0.34 43.21  ? 626  GLU A CA  1 
ATOM   2543 C  C   . GLU A 1 363 ? 6.629   -26.798 -40.109 0.34 43.48  ? 626  GLU A C   1 
ATOM   2544 O  O   . GLU A 1 363 ? 6.757   -26.505 -41.312 0.34 44.30  ? 626  GLU A O   1 
ATOM   2545 C  CB  . GLU A 1 363 ? 4.500   -28.149 -40.408 0.34 43.63  ? 626  GLU A CB  1 
ATOM   2546 C  CG  . GLU A 1 363 ? 3.908   -29.549 -40.428 0.34 43.93  ? 626  GLU A CG  1 
ATOM   2547 C  CD  . GLU A 1 363 ? 2.590   -29.684 -41.171 0.34 44.47  ? 626  GLU A CD  1 
ATOM   2548 O  OE1 . GLU A 1 363 ? 2.297   -28.816 -42.016 0.34 44.53  ? 626  GLU A OE1 1 
ATOM   2549 O  OE2 . GLU A 1 363 ? 1.854   -30.657 -40.898 0.34 44.30  ? 626  GLU A OE2 1 
ATOM   2550 N  N   . GLY A 1 364 ? 7.108   -26.060 -39.102 1.00 42.45  ? 627  GLY A N   1 
ATOM   2551 C  CA  . GLY A 1 364 ? 7.845   -24.795 -39.308 1.00 47.99  ? 627  GLY A CA  1 
ATOM   2552 C  C   . GLY A 1 364 ? 7.046   -23.693 -40.007 1.00 54.44  ? 627  GLY A C   1 
ATOM   2553 O  O   . GLY A 1 364 ? 7.629   -22.954 -40.843 1.00 55.39  ? 627  GLY A O   1 
ATOM   2554 N  N   . VAL A 1 365 ? 5.766   -23.545 -39.648 0.34 52.47  ? 628  VAL A N   1 
ATOM   2555 C  CA  . VAL A 1 365 ? 4.868   -22.466 -40.158 0.34 52.15  ? 628  VAL A CA  1 
ATOM   2556 C  C   . VAL A 1 365 ? 5.276   -21.139 -39.504 0.34 51.68  ? 628  VAL A C   1 
ATOM   2557 O  O   . VAL A 1 365 ? 5.044   -20.086 -40.121 0.34 52.42  ? 628  VAL A O   1 
ATOM   2558 C  CB  . VAL A 1 365 ? 3.384   -22.792 -39.898 0.34 52.21  ? 628  VAL A CB  1 
ATOM   2559 C  CG1 . VAL A 1 365 ? 2.472   -21.675 -40.378 0.34 52.02  ? 628  VAL A CG1 1 
ATOM   2560 C  CG2 . VAL A 1 365 ? 2.977   -24.116 -40.526 0.34 52.49  ? 628  VAL A CG2 1 
ATOM   2561 N  N   . PHE A 1 366 ? 5.859   -21.197 -38.302 0.34 51.99  ? 629  PHE A N   1 
ATOM   2562 C  CA  . PHE A 1 366 ? 6.320   -20.021 -37.517 0.34 54.29  ? 629  PHE A CA  1 
ATOM   2563 C  C   . PHE A 1 366 ? 7.573   -20.396 -36.717 0.34 56.48  ? 629  PHE A C   1 
ATOM   2564 O  O   . PHE A 1 366 ? 7.695   -21.559 -36.290 0.34 57.65  ? 629  PHE A O   1 
ATOM   2565 C  CB  . PHE A 1 366 ? 5.208   -19.520 -36.592 0.34 53.82  ? 629  PHE A CB  1 
ATOM   2566 C  CG  . PHE A 1 366 ? 4.936   -20.402 -35.400 0.34 53.69  ? 629  PHE A CG  1 
ATOM   2567 C  CD1 . PHE A 1 366 ? 5.645   -20.240 -34.222 0.34 53.87  ? 629  PHE A CD1 1 
ATOM   2568 C  CD2 . PHE A 1 366 ? 3.964   -21.388 -35.454 0.34 54.14  ? 629  PHE A CD2 1 
ATOM   2569 C  CE1 . PHE A 1 366 ? 5.389   -21.048 -33.125 0.34 54.92  ? 629  PHE A CE1 1 
ATOM   2570 C  CE2 . PHE A 1 366 ? 3.711   -22.196 -34.357 0.34 53.77  ? 629  PHE A CE2 1 
ATOM   2571 C  CZ  . PHE A 1 366 ? 4.423   -22.025 -33.195 0.34 53.85  ? 629  PHE A CZ  1 
ATOM   2572 N  N   . LYS A 1 367 ? 8.465   -19.425 -36.505 0.34 58.26  ? 630  LYS A N   1 
ATOM   2573 C  CA  . LYS A 1 367 ? 9.836   -19.651 -35.975 0.34 59.41  ? 630  LYS A CA  1 
ATOM   2574 C  C   . LYS A 1 367 ? 9.873   -19.364 -34.470 0.34 57.38  ? 630  LYS A C   1 
ATOM   2575 O  O   . LYS A 1 367 ? 10.465  -20.172 -33.734 0.34 56.81  ? 630  LYS A O   1 
ATOM   2576 C  CB  . LYS A 1 367 ? 10.837  -18.777 -36.737 0.34 62.97  ? 630  LYS A CB  1 
ATOM   2577 C  CG  . LYS A 1 367 ? 10.950  -19.080 -38.227 0.34 66.40  ? 630  LYS A CG  1 
ATOM   2578 C  CD  . LYS A 1 367 ? 11.885  -18.147 -38.979 0.34 68.57  ? 630  LYS A CD  1 
ATOM   2579 C  CE  . LYS A 1 367 ? 13.350  -18.385 -38.671 0.34 69.05  ? 630  LYS A CE  1 
ATOM   2580 N  NZ  . LYS A 1 367 ? 13.704  -17.963 -37.294 0.34 68.51  ? 630  LYS A NZ  1 
ATOM   2581 N  N   . SER A 1 368 ? 9.268   -18.259 -34.030 0.34 55.84  ? 631  SER A N   1 
ATOM   2582 C  CA  . SER A 1 368 ? 9.319   -17.785 -32.622 0.34 56.43  ? 631  SER A CA  1 
ATOM   2583 C  C   . SER A 1 368 ? 7.915   -17.453 -32.110 0.34 55.74  ? 631  SER A C   1 
ATOM   2584 O  O   . SER A 1 368 ? 7.122   -16.873 -32.874 0.34 53.95  ? 631  SER A O   1 
ATOM   2585 C  CB  . SER A 1 368 ? 10.228  -16.592 -32.482 0.34 58.33  ? 631  SER A CB  1 
ATOM   2586 O  OG  . SER A 1 368 ? 9.762   -15.722 -31.456 0.34 58.80  ? 631  SER A OG  1 
ATOM   2587 N  N   . ILE A 1 369 ? 7.654   -17.788 -30.844 0.34 55.53  ? 632  ILE A N   1 
ATOM   2588 C  CA  . ILE A 1 369 ? 6.373   -17.520 -30.129 0.34 57.38  ? 632  ILE A CA  1 
ATOM   2589 C  C   . ILE A 1 369 ? 6.431   -16.115 -29.523 0.34 59.15  ? 632  ILE A C   1 
ATOM   2590 O  O   . ILE A 1 369 ? 5.373   -15.614 -29.092 0.34 54.09  ? 632  ILE A O   1 
ATOM   2591 C  CB  . ILE A 1 369 ? 6.135   -18.583 -29.043 0.34 56.57  ? 632  ILE A CB  1 
ATOM   2592 C  CG1 . ILE A 1 369 ? 7.225   -18.534 -27.969 0.34 55.95  ? 632  ILE A CG1 1 
ATOM   2593 C  CG2 . ILE A 1 369 ? 6.006   -19.967 -29.660 0.34 57.58  ? 632  ILE A CG2 1 
ATOM   2594 C  CD1 . ILE A 1 369 ? 6.937   -19.400 -26.771 0.34 56.55  ? 632  ILE A CD1 1 
ATOM   2595 N  N   . GLN A 1 370 ? 7.629   -15.522 -29.477 0.34 62.34  ? 633  GLN A N   1 
ATOM   2596 C  CA  . GLN A 1 370 ? 7.887   -14.199 -28.847 0.34 63.30  ? 633  GLN A CA  1 
ATOM   2597 C  C   . GLN A 1 370 ? 7.112   -13.127 -29.621 0.34 62.34  ? 633  GLN A C   1 
ATOM   2598 O  O   . GLN A 1 370 ? 6.518   -12.245 -28.976 0.34 60.70  ? 633  GLN A O   1 
ATOM   2599 C  CB  . GLN A 1 370 ? 9.387   -13.899 -28.829 0.34 65.23  ? 633  GLN A CB  1 
ATOM   2600 C  CG  . GLN A 1 370 ? 9.847   -13.192 -27.561 0.34 66.12  ? 633  GLN A CG  1 
ATOM   2601 C  CD  . GLN A 1 370 ? 9.834   -14.110 -26.363 0.34 67.48  ? 633  GLN A CD  1 
ATOM   2602 O  OE1 . GLN A 1 370 ? 9.589   -15.309 -26.476 0.34 69.52  ? 633  GLN A OE1 1 
ATOM   2603 N  NE2 . GLN A 1 370 ? 10.103  -13.549 -25.195 0.34 68.00  ? 633  GLN A NE2 1 
ATOM   2604 N  N   . HIS A 1 371 ? 7.115   -13.224 -30.953 0.34 62.96  ? 634  HIS A N   1 
ATOM   2605 C  CA  . HIS A 1 371 ? 6.441   -12.280 -31.883 0.34 64.98  ? 634  HIS A CA  1 
ATOM   2606 C  C   . HIS A 1 371 ? 6.228   -12.957 -33.241 0.34 64.59  ? 634  HIS A C   1 
ATOM   2607 O  O   . HIS A 1 371 ? 7.130   -13.691 -33.687 0.34 61.70  ? 634  HIS A O   1 
ATOM   2608 C  CB  . HIS A 1 371 ? 7.254   -10.984 -32.016 0.34 67.47  ? 634  HIS A CB  1 
ATOM   2609 C  CG  . HIS A 1 371 ? 6.894   -10.175 -33.217 0.34 69.64  ? 634  HIS A CG  1 
ATOM   2610 N  ND1 . HIS A 1 371 ? 5.780   -9.355  -33.250 0.34 71.52  ? 634  HIS A ND1 1 
ATOM   2611 C  CD2 . HIS A 1 371 ? 7.486   -10.060 -34.426 0.34 70.74  ? 634  HIS A CD2 1 
ATOM   2612 C  CE1 . HIS A 1 371 ? 5.704   -8.766  -34.426 0.34 71.53  ? 634  HIS A CE1 1 
ATOM   2613 N  NE2 . HIS A 1 371 ? 6.739   -9.183  -35.168 0.34 72.12  ? 634  HIS A NE2 1 
ATOM   2614 N  N   . LEU A 1 372 ? 5.077   -12.703 -33.869 0.34 67.37  ? 635  LEU A N   1 
ATOM   2615 C  CA  . LEU A 1 372 ? 4.698   -13.248 -35.199 0.34 69.88  ? 635  LEU A CA  1 
ATOM   2616 C  C   . LEU A 1 372 ? 4.785   -12.127 -36.241 0.34 70.90  ? 635  LEU A C   1 
ATOM   2617 O  O   . LEU A 1 372 ? 4.101   -11.100 -36.056 0.34 72.23  ? 635  LEU A O   1 
ATOM   2618 C  CB  . LEU A 1 372 ? 3.279   -13.821 -35.112 0.34 71.37  ? 635  LEU A CB  1 
ATOM   2619 C  CG  . LEU A 1 372 ? 2.936   -14.898 -36.140 0.34 71.89  ? 635  LEU A CG  1 
ATOM   2620 C  CD1 . LEU A 1 372 ? 3.787   -16.140 -35.926 0.34 72.18  ? 635  LEU A CD1 1 
ATOM   2621 C  CD2 . LEU A 1 372 ? 1.458   -15.250 -36.084 0.34 72.49  ? 635  LEU A CD2 1 
ATOM   2622 N  N   . THR A 1 373 ? 5.602   -12.318 -37.283 0.34 70.71  ? 636  THR A N   1 
ATOM   2623 C  CA  . THR A 1 373 ? 5.788   -11.360 -38.406 0.34 70.82  ? 636  THR A CA  1 
ATOM   2624 C  C   . THR A 1 373 ? 4.477   -11.256 -39.192 0.34 71.43  ? 636  THR A C   1 
ATOM   2625 O  O   . THR A 1 373 ? 3.642   -12.172 -39.062 0.34 72.30  ? 636  THR A O   1 
ATOM   2626 C  CB  . THR A 1 373 ? 6.948   -11.782 -39.318 0.34 70.59  ? 636  THR A CB  1 
ATOM   2627 O  OG1 . THR A 1 373 ? 6.483   -12.804 -40.200 0.34 70.84  ? 636  THR A OG1 1 
ATOM   2628 C  CG2 . THR A 1 373 ? 8.154   -12.280 -38.551 0.34 70.47  ? 636  THR A CG2 1 
ATOM   2629 N  N   . VAL A 1 374 ? 4.306   -10.182 -39.968 0.34 72.58  ? 637  VAL A N   1 
ATOM   2630 C  CA  . VAL A 1 374 ? 3.112   -9.956  -40.837 0.34 75.70  ? 637  VAL A CA  1 
ATOM   2631 C  C   . VAL A 1 374 ? 3.027   -11.102 -41.850 0.34 75.89  ? 637  VAL A C   1 
ATOM   2632 O  O   . VAL A 1 374 ? 1.902   -11.565 -42.133 0.34 74.18  ? 637  VAL A O   1 
ATOM   2633 C  CB  . VAL A 1 374 ? 3.175   -8.588  -41.544 0.34 77.66  ? 637  VAL A CB  1 
ATOM   2634 C  CG1 . VAL A 1 374 ? 2.687   -7.464  -40.643 0.34 78.14  ? 637  VAL A CG1 1 
ATOM   2635 C  CG2 . VAL A 1 374 ? 4.568   -8.289  -42.080 0.34 77.93  ? 637  VAL A CG2 1 
ATOM   2636 N  N   . THR A 1 375 ? 4.180   -11.535 -42.368 0.34 76.62  ? 638  THR A N   1 
ATOM   2637 C  CA  . THR A 1 375 ? 4.313   -12.614 -43.382 0.34 78.00  ? 638  THR A CA  1 
ATOM   2638 C  C   . THR A 1 375 ? 3.965   -13.965 -42.743 0.34 76.46  ? 638  THR A C   1 
ATOM   2639 O  O   . THR A 1 375 ? 3.370   -14.808 -43.443 0.34 75.05  ? 638  THR A O   1 
ATOM   2640 C  CB  . THR A 1 375 ? 5.719   -12.619 -43.995 0.34 79.77  ? 638  THR A CB  1 
ATOM   2641 O  OG1 . THR A 1 375 ? 6.671   -12.740 -42.938 0.34 81.80  ? 638  THR A OG1 1 
ATOM   2642 C  CG2 . THR A 1 375 ? 6.012   -11.371 -44.799 0.34 80.61  ? 638  THR A CG2 1 
ATOM   2643 N  N   . GLU A 1 376 ? 4.330   -14.158 -41.470 0.34 74.08  ? 639  GLU A N   1 
ATOM   2644 C  CA  . GLU A 1 376 ? 4.051   -15.399 -40.699 0.34 72.76  ? 639  GLU A CA  1 
ATOM   2645 C  C   . GLU A 1 376 ? 2.540   -15.498 -40.460 0.34 70.41  ? 639  GLU A C   1 
ATOM   2646 O  O   . GLU A 1 376 ? 1.978   -16.581 -40.707 0.34 67.53  ? 639  GLU A O   1 
ATOM   2647 C  CB  . GLU A 1 376 ? 4.854   -15.422 -39.395 0.34 72.12  ? 639  GLU A CB  1 
ATOM   2648 C  CG  . GLU A 1 376 ? 6.273   -15.940 -39.576 0.34 71.97  ? 639  GLU A CG  1 
ATOM   2649 C  CD  . GLU A 1 376 ? 7.117   -15.994 -38.313 0.34 72.10  ? 639  GLU A CD  1 
ATOM   2650 O  OE1 . GLU A 1 376 ? 8.033   -16.838 -38.253 0.34 73.10  ? 639  GLU A OE1 1 
ATOM   2651 O  OE2 . GLU A 1 376 ? 6.866   -15.189 -37.395 0.34 71.97  ? 639  GLU A OE2 1 
ATOM   2652 N  N   . GLU A 1 377 ? 1.909   -14.400 -40.031 0.34 69.25  ? 640  GLU A N   1 
ATOM   2653 C  CA  . GLU A 1 377 ? 0.436   -14.305 -39.841 0.34 68.99  ? 640  GLU A CA  1 
ATOM   2654 C  C   . GLU A 1 377 ? -0.263  -14.786 -41.117 0.34 69.24  ? 640  GLU A C   1 
ATOM   2655 O  O   . GLU A 1 377 ? -1.179  -15.619 -41.006 0.34 72.21  ? 640  GLU A O   1 
ATOM   2656 C  CB  . GLU A 1 377 ? 0.017   -12.875 -39.501 0.34 69.27  ? 640  GLU A CB  1 
ATOM   2657 C  CG  . GLU A 1 377 ? 0.479   -12.418 -38.130 0.34 70.20  ? 640  GLU A CG  1 
ATOM   2658 C  CD  . GLU A 1 377 ? 0.101   -10.985 -37.800 0.34 69.72  ? 640  GLU A CD  1 
ATOM   2659 O  OE1 . GLU A 1 377 ? -0.772  -10.436 -38.501 0.34 69.76  ? 640  GLU A OE1 1 
ATOM   2660 O  OE2 . GLU A 1 377 ? 0.685   -10.421 -36.850 0.34 67.06  ? 640  GLU A OE2 1 
ATOM   2661 N  N   . ILE A 1 378 ? 0.160   -14.283 -42.280 0.34 70.10  ? 641  ILE A N   1 
ATOM   2662 C  CA  . ILE A 1 378 ? -0.421  -14.651 -43.607 0.34 71.16  ? 641  ILE A CA  1 
ATOM   2663 C  C   . ILE A 1 378 ? -0.162  -16.142 -43.862 0.34 68.44  ? 641  ILE A C   1 
ATOM   2664 O  O   . ILE A 1 378 ? -1.068  -16.806 -44.400 0.34 69.30  ? 641  ILE A O   1 
ATOM   2665 C  CB  . ILE A 1 378 ? 0.143   -13.761 -44.736 0.34 72.56  ? 641  ILE A CB  1 
ATOM   2666 C  CG1 . ILE A 1 378 ? -0.962  -13.257 -45.668 0.34 74.00  ? 641  ILE A CG1 1 
ATOM   2667 C  CG2 . ILE A 1 378 ? 1.242   -14.479 -45.506 0.34 73.17  ? 641  ILE A CG2 1 
ATOM   2668 C  CD1 . ILE A 1 378 ? -1.708  -14.354 -46.393 0.34 75.59  ? 641  ILE A CD1 1 
ATOM   2669 N  N   . ALA A 1 379 ? 1.018   -16.646 -43.483 1.00 65.69  ? 642  ALA A N   1 
ATOM   2670 C  CA  . ALA A 1 379 ? 1.408   -18.066 -43.690 1.00 66.57  ? 642  ALA A CA  1 
ATOM   2671 C  C   . ALA A 1 379 ? 0.569   -19.008 -42.800 1.00 56.94  ? 642  ALA A C   1 
ATOM   2672 O  O   . ALA A 1 379 ? 0.120   -20.040 -43.321 1.00 45.26  ? 642  ALA A O   1 
ATOM   2673 C  CB  . ALA A 1 379 ? 2.891   -18.245 -43.460 1.00 60.71  ? 642  ALA A CB  1 
ATOM   2674 N  N   . VAL A 1 380 ? 0.358   -18.649 -41.528 1.00 48.26  ? 643  VAL A N   1 
ATOM   2675 C  CA  . VAL A 1 380 ? -0.530  -19.378 -40.581 1.00 51.74  ? 643  VAL A CA  1 
ATOM   2676 C  C   . VAL A 1 380 ? -1.953  -19.473 -41.169 1.00 54.16  ? 643  VAL A C   1 
ATOM   2677 O  O   . VAL A 1 380 ? -2.527  -20.590 -41.213 1.00 48.07  ? 643  VAL A O   1 
ATOM   2678 C  CB  . VAL A 1 380 ? -0.496  -18.737 -39.183 1.00 48.45  ? 643  VAL A CB  1 
ATOM   2679 C  CG1 . VAL A 1 380 ? -1.625  -19.231 -38.290 1.00 48.80  ? 643  VAL A CG1 1 
ATOM   2680 C  CG2 . VAL A 1 380 ? 0.829   -19.006 -38.500 1.00 48.09  ? 643  VAL A CG2 1 
ATOM   2681 N  N   . LYS A 1 381 ? -2.507  -18.333 -41.598 0.34 52.55  ? 644  LYS A N   1 
ATOM   2682 C  CA  . LYS A 1 381 ? -3.868  -18.223 -42.190 0.34 52.79  ? 644  LYS A CA  1 
ATOM   2683 C  C   . LYS A 1 381 ? -3.944  -19.106 -43.439 0.34 52.69  ? 644  LYS A C   1 
ATOM   2684 O  O   . LYS A 1 381 ? -4.941  -19.845 -43.585 0.34 51.18  ? 644  LYS A O   1 
ATOM   2685 C  CB  . LYS A 1 381 ? -4.194  -16.769 -42.544 0.34 54.37  ? 644  LYS A CB  1 
ATOM   2686 C  CG  . LYS A 1 381 ? -4.365  -15.833 -41.355 0.34 56.67  ? 644  LYS A CG  1 
ATOM   2687 C  CD  . LYS A 1 381 ? -4.748  -14.416 -41.742 0.34 57.33  ? 644  LYS A CD  1 
ATOM   2688 C  CE  . LYS A 1 381 ? -4.820  -13.472 -40.559 0.34 56.41  ? 644  LYS A CE  1 
ATOM   2689 N  NZ  . LYS A 1 381 ? -3.480  -13.190 -39.992 0.34 56.02  ? 644  LYS A NZ  1 
ATOM   2690 N  N   . ASN A 1 382 ? -2.917  -19.034 -44.291 0.34 51.36  ? 645  ASN A N   1 
ATOM   2691 C  CA  . ASN A 1 382 ? -2.841  -19.776 -45.576 0.34 51.76  ? 645  ASN A CA  1 
ATOM   2692 C  C   . ASN A 1 382 ? -2.743  -21.276 -45.273 0.34 50.67  ? 645  ASN A C   1 
ATOM   2693 O  O   . ASN A 1 382 ? -3.386  -22.066 -45.989 0.34 48.79  ? 645  ASN A O   1 
ATOM   2694 C  CB  . ASN A 1 382 ? -1.676  -19.286 -46.442 0.34 54.36  ? 645  ASN A CB  1 
ATOM   2695 C  CG  . ASN A 1 382 ? -1.812  -17.835 -46.861 0.34 56.43  ? 645  ASN A CG  1 
ATOM   2696 O  OD1 . ASN A 1 382 ? -2.659  -17.105 -46.347 0.34 56.20  ? 645  ASN A OD1 1 
ATOM   2697 N  ND2 . ASN A 1 382 ? -0.978  -17.406 -47.796 0.34 57.02  ? 645  ASN A ND2 1 
ATOM   2698 N  N   . TRP A 1 383 ? -1.969  -21.646 -44.248 0.34 49.62  ? 646  TRP A N   1 
ATOM   2699 C  CA  . TRP A 1 383 ? -1.838  -23.044 -43.754 0.34 46.55  ? 646  TRP A CA  1 
ATOM   2700 C  C   . TRP A 1 383 ? -3.236  -23.558 -43.377 0.34 43.02  ? 646  TRP A C   1 
ATOM   2701 O  O   . TRP A 1 383 ? -3.672  -24.574 -43.956 0.34 39.69  ? 646  TRP A O   1 
ATOM   2702 C  CB  . TRP A 1 383 ? -0.842  -23.096 -42.588 0.34 45.69  ? 646  TRP A CB  1 
ATOM   2703 C  CG  . TRP A 1 383 ? -0.475  -24.472 -42.122 0.34 47.98  ? 646  TRP A CG  1 
ATOM   2704 C  CD1 . TRP A 1 383 ? 0.510   -25.281 -42.614 0.34 48.31  ? 646  TRP A CD1 1 
ATOM   2705 C  CD2 . TRP A 1 383 ? -1.073  -25.192 -41.030 0.34 48.71  ? 646  TRP A CD2 1 
ATOM   2706 N  NE1 . TRP A 1 383 ? 0.556   -26.457 -41.913 0.34 47.71  ? 646  TRP A NE1 1 
ATOM   2707 C  CE2 . TRP A 1 383 ? -0.402  -26.430 -40.934 0.34 47.97  ? 646  TRP A CE2 1 
ATOM   2708 C  CE3 . TRP A 1 383 ? -2.107  -24.911 -40.131 0.34 47.53  ? 646  TRP A CE3 1 
ATOM   2709 C  CZ2 . TRP A 1 383 ? -0.738  -27.381 -39.974 0.34 47.18  ? 646  TRP A CZ2 1 
ATOM   2710 C  CZ3 . TRP A 1 383 ? -2.436  -25.852 -39.181 0.34 47.44  ? 646  TRP A CZ3 1 
ATOM   2711 C  CH2 . TRP A 1 383 ? -1.757  -27.068 -39.105 0.34 47.55  ? 646  TRP A CH2 1 
ATOM   2712 N  N   . LEU A 1 384 ? -3.933  -22.836 -42.496 1.00 39.76  ? 647  LEU A N   1 
ATOM   2713 C  CA  . LEU A 1 384 ? -5.295  -23.210 -42.033 1.00 45.40  ? 647  LEU A CA  1 
ATOM   2714 C  C   . LEU A 1 384 ? -6.260  -23.421 -43.213 1.00 46.76  ? 647  LEU A C   1 
ATOM   2715 O  O   . LEU A 1 384 ? -6.944  -24.445 -43.259 1.00 43.80  ? 647  LEU A O   1 
ATOM   2716 C  CB  . LEU A 1 384 ? -5.777  -22.141 -41.054 1.00 41.69  ? 647  LEU A CB  1 
ATOM   2717 C  CG  . LEU A 1 384 ? -5.099  -22.194 -39.683 1.00 43.57  ? 647  LEU A CG  1 
ATOM   2718 C  CD1 . LEU A 1 384 ? -5.393  -20.939 -38.887 1.00 46.70  ? 647  LEU A CD1 1 
ATOM   2719 C  CD2 . LEU A 1 384 ? -5.510  -23.426 -38.883 1.00 43.24  ? 647  LEU A CD2 1 
ATOM   2720 N  N   . VAL A 1 385 ? -6.286  -22.475 -44.156 0.34 49.33  ? 648  VAL A N   1 
ATOM   2721 C  CA  . VAL A 1 385 ? -7.194  -22.497 -45.342 0.34 49.77  ? 648  VAL A CA  1 
ATOM   2722 C  C   . VAL A 1 385 ? -6.799  -23.664 -46.254 0.34 49.92  ? 648  VAL A C   1 
ATOM   2723 O  O   . VAL A 1 385 ? -7.708  -24.345 -46.767 0.34 50.94  ? 648  VAL A O   1 
ATOM   2724 C  CB  . VAL A 1 385 ? -7.166  -21.152 -46.095 0.34 51.14  ? 648  VAL A CB  1 
ATOM   2725 C  CG1 . VAL A 1 385 ? -7.852  -21.248 -47.450 0.34 51.41  ? 648  VAL A CG1 1 
ATOM   2726 C  CG2 . VAL A 1 385 ? -7.775  -20.032 -45.265 0.34 51.27  ? 648  VAL A CG2 1 
ATOM   2727 N  N   . ARG A 1 386 ? -5.494  -23.886 -46.437 1.00 49.79  ? 649  ARG A N   1 
ATOM   2728 C  CA  . ARG A 1 386 ? -4.965  -24.914 -47.367 1.00 51.74  ? 649  ARG A CA  1 
ATOM   2729 C  C   . ARG A 1 386 ? -5.072  -26.312 -46.724 1.00 51.27  ? 649  ARG A C   1 
ATOM   2730 O  O   . ARG A 1 386 ? -5.462  -27.258 -47.439 1.00 48.74  ? 649  ARG A O   1 
ATOM   2731 C  CB  . ARG A 1 386 ? -3.555  -24.420 -47.725 1.00 59.26  ? 649  ARG A CB  1 
ATOM   2732 C  CG  . ARG A 1 386 ? -2.847  -25.018 -48.931 1.00 64.43  ? 649  ARG A CG  1 
ATOM   2733 C  CD  . ARG A 1 386 ? -1.451  -24.375 -49.034 1.00 70.92  ? 649  ARG A CD  1 
ATOM   2734 N  NE  . ARG A 1 386 ? -0.447  -25.005 -48.154 1.00 67.94  ? 649  ARG A NE  1 
ATOM   2735 C  CZ  . ARG A 1 386 ? 0.276   -24.414 -47.185 1.00 62.33  ? 649  ARG A CZ  1 
ATOM   2736 N  NH1 . ARG A 1 386 ? 0.178   -23.118 -46.912 1.00 60.32  ? 649  ARG A NH1 1 
ATOM   2737 N  NH2 . ARG A 1 386 ? 1.118   -25.149 -46.480 1.00 63.65  ? 649  ARG A NH2 1 
ATOM   2738 N  N   . VAL A 1 387 ? -4.737  -26.486 -45.438 1.00 45.59  ? 650  VAL A N   1 
ATOM   2739 C  CA  . VAL A 1 387 ? -4.556  -27.869 -44.885 1.00 50.01  ? 650  VAL A CA  1 
ATOM   2740 C  C   . VAL A 1 387 ? -5.262  -28.083 -43.535 1.00 43.81  ? 650  VAL A C   1 
ATOM   2741 O  O   . VAL A 1 387 ? -5.204  -29.247 -43.047 1.00 47.13  ? 650  VAL A O   1 
ATOM   2742 C  CB  . VAL A 1 387 ? -3.061  -28.247 -44.768 1.00 44.77  ? 650  VAL A CB  1 
ATOM   2743 C  CG1 . VAL A 1 387 ? -2.394  -28.292 -46.126 1.00 44.38  ? 650  VAL A CG1 1 
ATOM   2744 C  CG2 . VAL A 1 387 ? -2.305  -27.337 -43.807 1.00 45.32  ? 650  VAL A CG2 1 
ATOM   2745 N  N   . GLY A 1 388 ? -5.868  -27.042 -42.960 1.00 39.31  ? 651  GLY A N   1 
ATOM   2746 C  CA  . GLY A 1 388 ? -6.519  -27.067 -41.637 1.00 39.55  ? 651  GLY A CA  1 
ATOM   2747 C  C   . GLY A 1 388 ? -7.420  -28.279 -41.488 1.00 39.14  ? 651  GLY A C   1 
ATOM   2748 O  O   . GLY A 1 388 ? -7.285  -29.009 -40.504 1.00 38.69  ? 651  GLY A O   1 
ATOM   2749 N  N   . ARG A 1 389 ? -8.265  -28.532 -42.470 1.00 36.94  ? 652  ARG A N   1 
ATOM   2750 C  CA  . ARG A 1 389 ? -9.266  -29.617 -42.379 1.00 41.38  ? 652  ARG A CA  1 
ATOM   2751 C  C   . ARG A 1 389 ? -8.525  -30.961 -42.356 1.00 38.67  ? 652  ARG A C   1 
ATOM   2752 O  O   . ARG A 1 389 ? -8.900  -31.834 -41.554 1.00 42.34  ? 652  ARG A O   1 
ATOM   2753 C  CB  . ARG A 1 389 ? -10.315 -29.511 -43.495 1.00 36.71  ? 652  ARG A CB  1 
ATOM   2754 C  CG  . ARG A 1 389 ? -11.246 -28.322 -43.311 1.00 41.74  ? 652  ARG A CG  1 
ATOM   2755 C  CD  . ARG A 1 389 ? -12.372 -28.295 -44.326 1.00 42.86  ? 652  ARG A CD  1 
ATOM   2756 N  NE  . ARG A 1 389 ? -13.253 -29.451 -44.247 1.00 45.37  ? 652  ARG A NE  1 
ATOM   2757 C  CZ  . ARG A 1 389 ? -14.330 -29.546 -43.457 1.00 47.80  ? 652  ARG A CZ  1 
ATOM   2758 N  NH1 . ARG A 1 389 ? -14.670 -28.570 -42.623 1.00 44.84  ? 652  ARG A NH1 1 
ATOM   2759 N  NH2 . ARG A 1 389 ? -15.034 -30.664 -43.469 1.00 49.72  ? 652  ARG A NH2 1 
ATOM   2760 N  N   . GLU A 1 390 ? -7.522  -31.131 -43.224 0.34 36.85  ? 653  GLU A N   1 
ATOM   2761 C  CA  . GLU A 1 390 ? -6.684  -32.364 -43.288 0.34 36.52  ? 653  GLU A CA  1 
ATOM   2762 C  C   . GLU A 1 390 ? -6.037  -32.606 -41.918 0.34 36.05  ? 653  GLU A C   1 
ATOM   2763 O  O   . GLU A 1 390 ? -6.073  -33.754 -41.441 0.34 35.91  ? 653  GLU A O   1 
ATOM   2764 C  CB  . GLU A 1 390 ? -5.601  -32.250 -44.361 0.34 35.01  ? 653  GLU A CB  1 
ATOM   2765 C  CG  . GLU A 1 390 ? -4.872  -33.558 -44.629 0.34 33.95  ? 653  GLU A CG  1 
ATOM   2766 C  CD  . GLU A 1 390 ? -3.887  -34.005 -43.558 0.34 33.09  ? 653  GLU A CD  1 
ATOM   2767 O  OE1 . GLU A 1 390 ? -3.448  -33.154 -42.753 0.34 30.98  ? 653  GLU A OE1 1 
ATOM   2768 O  OE2 . GLU A 1 390 ? -3.557  -35.211 -43.528 0.34 32.68  ? 653  GLU A OE2 1 
ATOM   2769 N  N   . ARG A 1 391 ? -5.486  -31.549 -41.317 1.00 36.19  ? 654  ARG A N   1 
ATOM   2770 C  CA  . ARG A 1 391 ? -4.740  -31.631 -40.042 1.00 38.07  ? 654  ARG A CA  1 
ATOM   2771 C  C   . ARG A 1 391 ? -5.678  -31.936 -38.862 1.00 35.88  ? 654  ARG A C   1 
ATOM   2772 O  O   . ARG A 1 391 ? -5.234  -32.582 -37.896 1.00 32.80  ? 654  ARG A O   1 
ATOM   2773 C  CB  . ARG A 1 391 ? -3.909  -30.361 -39.855 1.00 39.70  ? 654  ARG A CB  1 
ATOM   2774 C  CG  . ARG A 1 391 ? -2.936  -30.106 -40.998 1.00 40.82  ? 654  ARG A CG  1 
ATOM   2775 C  CD  . ARG A 1 391 ? -1.748  -31.044 -40.997 1.00 44.75  ? 654  ARG A CD  1 
ATOM   2776 N  NE  . ARG A 1 391 ? -0.707  -30.560 -41.881 1.00 43.99  ? 654  ARG A NE  1 
ATOM   2777 C  CZ  . ARG A 1 391 ? -0.587  -30.853 -43.174 1.00 47.98  ? 654  ARG A CZ  1 
ATOM   2778 N  NH1 . ARG A 1 391 ? -1.424  -31.675 -43.782 1.00 48.77  ? 654  ARG A NH1 1 
ATOM   2779 N  NH2 . ARG A 1 391 ? 0.405   -30.338 -43.870 1.00 52.62  ? 654  ARG A NH2 1 
ATOM   2780 N  N   . LEU A 1 392 ? -6.927  -31.462 -38.919 0.34 35.20  ? 655  LEU A N   1 
ATOM   2781 C  CA  . LEU A 1 392 ? -7.968  -31.781 -37.903 0.34 35.31  ? 655  LEU A CA  1 
ATOM   2782 C  C   . LEU A 1 392 ? -8.324  -33.267 -38.024 0.34 34.51  ? 655  LEU A C   1 
ATOM   2783 O  O   . LEU A 1 392 ? -8.571  -33.907 -36.986 0.34 34.77  ? 655  LEU A O   1 
ATOM   2784 C  CB  . LEU A 1 392 ? -9.200  -30.894 -38.114 0.34 36.10  ? 655  LEU A CB  1 
ATOM   2785 C  CG  . LEU A 1 392 ? -9.060  -29.441 -37.660 0.34 35.89  ? 655  LEU A CG  1 
ATOM   2786 C  CD1 . LEU A 1 392 ? -10.307 -28.642 -38.012 0.34 36.66  ? 655  LEU A CD1 1 
ATOM   2787 C  CD2 . LEU A 1 392 ? -8.775  -29.355 -36.167 0.34 35.67  ? 655  LEU A CD2 1 
ATOM   2788 N  N   . SER A 1 393 ? -8.313  -33.793 -39.249 0.34 33.97  ? 656  SER A N   1 
ATOM   2789 C  CA  . SER A 1 393 ? -8.710  -35.186 -39.575 0.34 34.87  ? 656  SER A CA  1 
ATOM   2790 C  C   . SER A 1 393 ? -7.653  -36.177 -39.076 0.34 34.34  ? 656  SER A C   1 
ATOM   2791 O  O   . SER A 1 393 ? -7.966  -37.380 -39.033 0.34 33.41  ? 656  SER A O   1 
ATOM   2792 C  CB  . SER A 1 393 ? -8.955  -35.342 -41.054 0.34 35.99  ? 656  SER A CB  1 
ATOM   2793 O  OG  . SER A 1 393 ? -7.808  -34.960 -41.802 0.34 37.08  ? 656  SER A OG  1 
ATOM   2794 N  N   . ARG A 1 394 ? -6.457  -35.695 -38.714 0.34 34.07  ? 657  ARG A N   1 
ATOM   2795 C  CA  . ARG A 1 394 ? -5.317  -36.543 -38.267 0.34 33.51  ? 657  ARG A CA  1 
ATOM   2796 C  C   . ARG A 1 394 ? -5.384  -36.778 -36.757 0.34 32.17  ? 657  ARG A C   1 
ATOM   2797 O  O   . ARG A 1 394 ? -4.437  -37.389 -36.225 0.34 30.09  ? 657  ARG A O   1 
ATOM   2798 C  CB  . ARG A 1 394 ? -3.968  -35.875 -38.551 0.34 35.66  ? 657  ARG A CB  1 
ATOM   2799 C  CG  . ARG A 1 394 ? -3.816  -35.350 -39.967 0.34 36.54  ? 657  ARG A CG  1 
ATOM   2800 C  CD  . ARG A 1 394 ? -2.407  -34.890 -40.274 0.34 36.70  ? 657  ARG A CD  1 
ATOM   2801 N  NE  . ARG A 1 394 ? -2.111  -35.247 -41.650 0.34 37.00  ? 657  ARG A NE  1 
ATOM   2802 C  CZ  . ARG A 1 394 ? -1.766  -36.466 -42.039 0.34 37.11  ? 657  ARG A CZ  1 
ATOM   2803 N  NH1 . ARG A 1 394 ? -1.644  -37.432 -41.145 0.34 39.53  ? 657  ARG A NH1 1 
ATOM   2804 N  NH2 . ARG A 1 394 ? -1.536  -36.717 -43.313 0.34 36.47  ? 657  ARG A NH2 1 
ATOM   2805 N  N   . MET A 1 395 ? -6.430  -36.279 -36.090 0.34 30.14  ? 658  MET A N   1 
ATOM   2806 C  CA  . MET A 1 395 ? -6.500  -36.248 -34.605 0.34 29.32  ? 658  MET A CA  1 
ATOM   2807 C  C   . MET A 1 395 ? -7.850  -36.772 -34.096 0.34 28.65  ? 658  MET A C   1 
ATOM   2808 O  O   . MET A 1 395 ? -8.841  -36.708 -34.838 0.34 27.83  ? 658  MET A O   1 
ATOM   2809 C  CB  . MET A 1 395 ? -6.267  -34.823 -34.098 0.34 29.74  ? 658  MET A CB  1 
ATOM   2810 C  CG  . MET A 1 395 ? -4.894  -34.296 -34.462 0.34 30.00  ? 658  MET A CG  1 
ATOM   2811 S  SD  . MET A 1 395 ? -4.524  -32.664 -33.782 0.34 30.22  ? 658  MET A SD  1 
ATOM   2812 C  CE  . MET A 1 395 ? -5.813  -31.678 -34.542 0.34 30.06  ? 658  MET A CE  1 
ATOM   2813 N  N   . ALA A 1 396 ? -7.844  -37.306 -32.871 1.00 27.03  ? 659  ALA A N   1 
ATOM   2814 C  CA  . ALA A 1 396 ? -9.032  -37.744 -32.132 1.00 28.86  ? 659  ALA A CA  1 
ATOM   2815 C  C   . ALA A 1 396 ? -8.919  -36.997 -30.801 1.00 29.89  ? 659  ALA A C   1 
ATOM   2816 O  O   . ALA A 1 396 ? -7.963  -37.220 -30.090 1.00 26.45  ? 659  ALA A O   1 
ATOM   2817 C  CB  . ALA A 1 396 ? -9.030  -39.240 -31.940 1.00 29.28  ? 659  ALA A CB  1 
ATOM   2818 N  N   . ILE A 1 397 ? -9.868  -36.100 -30.513 0.34 29.08  ? 660  ILE A N   1 
ATOM   2819 C  CA  . ILE A 1 397 ? -9.842  -35.218 -29.309 0.34 29.15  ? 660  ILE A CA  1 
ATOM   2820 C  C   . ILE A 1 397 ? -11.174 -35.333 -28.558 0.34 30.03  ? 660  ILE A C   1 
ATOM   2821 O  O   . ILE A 1 397 ? -12.235 -35.125 -29.184 0.34 28.81  ? 660  ILE A O   1 
ATOM   2822 C  CB  . ILE A 1 397 ? -9.521  -33.766 -29.703 0.34 29.40  ? 660  ILE A CB  1 
ATOM   2823 C  CG1 . ILE A 1 397 ? -8.067  -33.631 -30.167 0.34 30.66  ? 660  ILE A CG1 1 
ATOM   2824 C  CG2 . ILE A 1 397 ? -9.843  -32.821 -28.557 0.34 29.50  ? 660  ILE A CG2 1 
ATOM   2825 C  CD1 . ILE A 1 397 ? -7.669  -32.239 -30.584 0.34 30.53  ? 660  ILE A CD1 1 
ATOM   2826 N  N   . SER A 1 398 ? -11.094 -35.649 -27.261 1.00 29.08  ? 661  SER A N   1 
ATOM   2827 C  CA  . SER A 1 398 ? -12.237 -35.776 -26.347 1.00 32.68  ? 661  SER A CA  1 
ATOM   2828 C  C   . SER A 1 398 ? -11.947 -34.906 -25.131 1.00 34.10  ? 661  SER A C   1 
ATOM   2829 O  O   . SER A 1 398 ? -11.262 -35.399 -24.237 1.00 35.48  ? 661  SER A O   1 
ATOM   2830 C  CB  . SER A 1 398 ? -12.460 -37.204 -25.946 1.00 32.39  ? 661  SER A CB  1 
ATOM   2831 O  OG  . SER A 1 398 ? -13.709 -37.312 -25.288 1.00 32.37  ? 661  SER A OG  1 
ATOM   2832 N  N   . GLY A 1 399 ? -12.424 -33.663 -25.107 1.00 29.65  ? 662  GLY A N   1 
ATOM   2833 C  CA  . GLY A 1 399 ? -12.084 -32.751 -23.997 1.00 31.67  ? 662  GLY A CA  1 
ATOM   2834 C  C   . GLY A 1 399 ? -10.578 -32.572 -23.900 1.00 29.65  ? 662  GLY A C   1 
ATOM   2835 O  O   . GLY A 1 399 ? -9.939  -32.288 -24.943 1.00 31.81  ? 662  GLY A O   1 
ATOM   2836 N  N   . ASP A 1 400 ? -10.007 -32.779 -22.719 1.00 32.40  ? 663  ASP A N   1 
ATOM   2837 C  CA  . ASP A 1 400 ? -8.550  -32.593 -22.490 1.00 35.11  ? 663  ASP A CA  1 
ATOM   2838 C  C   . ASP A 1 400 ? -7.760  -33.779 -23.039 1.00 32.98  ? 663  ASP A C   1 
ATOM   2839 O  O   . ASP A 1 400 ? -6.547  -33.720 -23.008 1.00 34.37  ? 663  ASP A O   1 
ATOM   2840 C  CB  . ASP A 1 400 ? -8.244  -32.358 -21.014 1.00 41.76  ? 663  ASP A CB  1 
ATOM   2841 C  CG  . ASP A 1 400 ? -8.521  -33.539 -20.111 1.00 43.32  ? 663  ASP A CG  1 
ATOM   2842 O  OD1 . ASP A 1 400 ? -9.283  -34.412 -20.505 1.00 45.62  ? 663  ASP A OD1 1 
ATOM   2843 O  OD2 . ASP A 1 400 ? -7.963  -33.557 -19.013 1.00 53.69  ? 663  ASP A OD2 1 
ATOM   2844 N  N   . ASP A 1 401 ? -8.406  -34.789 -23.599 1.00 30.01  ? 664  ASP A N   1 
ATOM   2845 C  CA  . ASP A 1 401 ? -7.697  -36.003 -24.061 1.00 30.56  ? 664  ASP A CA  1 
ATOM   2846 C  C   . ASP A 1 401 ? -7.484  -35.938 -25.569 1.00 31.09  ? 664  ASP A C   1 
ATOM   2847 O  O   . ASP A 1 401 ? -8.433  -35.603 -26.246 1.00 31.57  ? 664  ASP A O   1 
ATOM   2848 C  CB  . ASP A 1 401 ? -8.479  -37.263 -23.714 1.00 33.71  ? 664  ASP A CB  1 
ATOM   2849 C  CG  . ASP A 1 401 ? -7.539  -38.434 -23.595 1.00 34.28  ? 664  ASP A CG  1 
ATOM   2850 O  OD1 . ASP A 1 401 ? -6.359  -38.165 -23.561 1.00 37.17  ? 664  ASP A OD1 1 
ATOM   2851 O  OD2 . ASP A 1 401 ? -7.992  -39.560 -23.544 1.00 36.99  ? 664  ASP A OD2 1 
ATOM   2852 N  N   . CYS A 1 402 ? -6.281  -36.251 -26.069 1.00 28.70  ? 665  CYS A N   1 
ATOM   2853 C  CA  . CYS A 1 402 ? -5.994  -36.228 -27.520 1.00 27.81  ? 665  CYS A CA  1 
ATOM   2854 C  C   . CYS A 1 402 ? -5.084  -37.367 -27.962 1.00 29.15  ? 665  CYS A C   1 
ATOM   2855 O  O   . CYS A 1 402 ? -4.239  -37.862 -27.166 1.00 31.46  ? 665  CYS A O   1 
ATOM   2856 C  CB  . CYS A 1 402 ? -5.344  -34.922 -27.954 1.00 33.28  ? 665  CYS A CB  1 
ATOM   2857 S  SG  . CYS A 1 402 ? -3.710  -34.614 -27.225 1.00 35.56  ? 665  CYS A SG  1 
ATOM   2858 N  N   . VAL A 1 403 ? -5.208  -37.673 -29.249 1.00 28.09  ? 666  VAL A N   1 
ATOM   2859 C  CA  . VAL A 1 403 ? -4.283  -38.524 -30.038 1.00 29.18  ? 666  VAL A CA  1 
ATOM   2860 C  C   . VAL A 1 403 ? -4.040  -37.757 -31.341 1.00 31.43  ? 666  VAL A C   1 
ATOM   2861 O  O   . VAL A 1 403 ? -5.028  -37.294 -31.950 1.00 30.59  ? 666  VAL A O   1 
ATOM   2862 C  CB  . VAL A 1 403 ? -4.896  -39.915 -30.262 1.00 29.31  ? 666  VAL A CB  1 
ATOM   2863 C  CG1 . VAL A 1 403 ? -4.047  -40.785 -31.173 1.00 29.24  ? 666  VAL A CG1 1 
ATOM   2864 C  CG2 . VAL A 1 403 ? -5.189  -40.604 -28.926 1.00 26.27  ? 666  VAL A CG2 1 
ATOM   2865 N  N   . VAL A 1 404 ? -2.780  -37.502 -31.673 1.00 28.98  ? 667  VAL A N   1 
ATOM   2866 C  CA  . VAL A 1 404 ? -2.386  -36.764 -32.905 1.00 32.15  ? 667  VAL A CA  1 
ATOM   2867 C  C   . VAL A 1 404 ? -1.435  -37.645 -33.698 1.00 32.44  ? 667  VAL A C   1 
ATOM   2868 O  O   . VAL A 1 404 ? -0.468  -38.162 -33.122 1.00 32.00  ? 667  VAL A O   1 
ATOM   2869 C  CB  . VAL A 1 404 ? -1.706  -35.422 -32.570 1.00 34.12  ? 667  VAL A CB  1 
ATOM   2870 C  CG1 . VAL A 1 404 ? -1.365  -34.619 -33.819 1.00 32.16  ? 667  VAL A CG1 1 
ATOM   2871 C  CG2 . VAL A 1 404 ? -2.539  -34.594 -31.600 1.00 34.45  ? 667  VAL A CG2 1 
ATOM   2872 N  N   . LYS A 1 405 ? -1.721  -37.818 -34.991 0.34 33.17  ? 668  LYS A N   1 
ATOM   2873 C  CA  . LYS A 1 405 ? -0.792  -38.417 -35.984 0.34 34.12  ? 668  LYS A CA  1 
ATOM   2874 C  C   . LYS A 1 405 ? -0.276  -37.301 -36.887 0.34 34.77  ? 668  LYS A C   1 
ATOM   2875 O  O   . LYS A 1 405 ? -0.837  -37.042 -37.950 0.34 32.93  ? 668  LYS A O   1 
ATOM   2876 C  CB  . LYS A 1 405 ? -1.475  -39.518 -36.798 0.34 34.99  ? 668  LYS A CB  1 
ATOM   2877 C  CG  . LYS A 1 405 ? -0.652  -40.009 -37.978 0.34 35.81  ? 668  LYS A CG  1 
ATOM   2878 C  CD  . LYS A 1 405 ? -0.655  -41.505 -38.166 0.34 36.22  ? 668  LYS A CD  1 
ATOM   2879 C  CE  . LYS A 1 405 ? 0.563   -41.973 -38.934 0.34 37.41  ? 668  LYS A CE  1 
ATOM   2880 N  NZ  . LYS A 1 405 ? 0.508   -43.422 -39.229 0.34 37.98  ? 668  LYS A NZ  1 
ATOM   2881 N  N   . PRO A 1 406 ? 0.815   -36.614 -36.482 0.34 35.45  ? 669  PRO A N   1 
ATOM   2882 C  CA  . PRO A 1 406 ? 1.334   -35.473 -37.232 0.34 35.75  ? 669  PRO A CA  1 
ATOM   2883 C  C   . PRO A 1 406 ? 1.928   -35.906 -38.577 0.34 35.92  ? 669  PRO A C   1 
ATOM   2884 O  O   . PRO A 1 406 ? 2.076   -37.101 -38.809 0.34 36.14  ? 669  PRO A O   1 
ATOM   2885 C  CB  . PRO A 1 406 ? 2.422   -34.910 -36.311 0.34 35.47  ? 669  PRO A CB  1 
ATOM   2886 C  CG  . PRO A 1 406 ? 2.889   -36.120 -35.536 0.34 35.66  ? 669  PRO A CG  1 
ATOM   2887 C  CD  . PRO A 1 406 ? 1.624   -36.916 -35.294 0.34 35.06  ? 669  PRO A CD  1 
ATOM   2888 N  N   . LEU A 1 407 ? 2.255   -34.925 -39.420 0.34 36.73  ? 670  LEU A N   1 
ATOM   2889 C  CA  . LEU A 1 407 ? 2.867   -35.138 -40.756 0.34 37.98  ? 670  LEU A CA  1 
ATOM   2890 C  C   . LEU A 1 407 ? 4.195   -35.896 -40.604 0.34 37.88  ? 670  LEU A C   1 
ATOM   2891 O  O   . LEU A 1 407 ? 4.538   -36.656 -41.528 0.34 37.64  ? 670  LEU A O   1 
ATOM   2892 C  CB  . LEU A 1 407 ? 3.068   -33.776 -41.424 0.34 39.29  ? 670  LEU A CB  1 
ATOM   2893 C  CG  . LEU A 1 407 ? 2.978   -33.780 -42.947 0.34 41.08  ? 670  LEU A CG  1 
ATOM   2894 C  CD1 . LEU A 1 407 ? 1.604   -34.240 -43.405 0.34 41.80  ? 670  LEU A CD1 1 
ATOM   2895 C  CD2 . LEU A 1 407 ? 3.296   -32.404 -43.508 0.34 42.85  ? 670  LEU A CD2 1 
ATOM   2896 N  N   . ASP A 1 408 ? 4.909   -35.698 -39.487 1.00 37.14  ? 671  ASP A N   1 
ATOM   2897 C  CA  . ASP A 1 408 ? 6.191   -36.417 -39.206 1.00 38.23  ? 671  ASP A CA  1 
ATOM   2898 C  C   . ASP A 1 408 ? 6.587   -36.240 -37.739 1.00 37.25  ? 671  ASP A C   1 
ATOM   2899 O  O   . ASP A 1 408 ? 5.838   -35.588 -37.019 1.00 37.59  ? 671  ASP A O   1 
ATOM   2900 C  CB  . ASP A 1 408 ? 7.291   -35.932 -40.164 1.00 40.57  ? 671  ASP A CB  1 
ATOM   2901 C  CG  . ASP A 1 408 ? 7.348   -34.422 -40.226 1.00 39.97  ? 671  ASP A CG  1 
ATOM   2902 O  OD1 . ASP A 1 408 ? 7.674   -33.818 -39.167 1.00 41.04  ? 671  ASP A OD1 1 
ATOM   2903 O  OD2 . ASP A 1 408 ? 6.976   -33.856 -41.295 1.00 42.32  ? 671  ASP A OD2 1 
ATOM   2904 N  N   . ASP A 1 409 ? 7.756   -36.742 -37.323 1.00 37.39  ? 672  ASP A N   1 
ATOM   2905 C  CA  . ASP A 1 409 ? 8.142   -36.742 -35.886 1.00 35.11  ? 672  ASP A CA  1 
ATOM   2906 C  C   . ASP A 1 409 ? 8.831   -35.442 -35.458 1.00 33.54  ? 672  ASP A C   1 
ATOM   2907 O  O   . ASP A 1 409 ? 9.189   -35.356 -34.275 1.00 36.73  ? 672  ASP A O   1 
ATOM   2908 C  CB  . ASP A 1 409 ? 8.870   -38.034 -35.538 1.00 38.09  ? 672  ASP A CB  1 
ATOM   2909 C  CG  . ASP A 1 409 ? 7.979   -39.251 -35.748 1.00 41.46  ? 672  ASP A CG  1 
ATOM   2910 O  OD1 . ASP A 1 409 ? 6.866   -39.274 -35.188 1.00 39.81  ? 672  ASP A OD1 1 
ATOM   2911 O  OD2 . ASP A 1 409 ? 8.388   -40.145 -36.497 1.00 45.46  ? 672  ASP A OD2 1 
ATOM   2912 N  N   . ARG A 1 410 ? 8.842   -34.380 -36.266 1.00 36.91  ? 673  ARG A N   1 
ATOM   2913 C  CA  . ARG A 1 410 ? 9.298   -33.050 -35.758 1.00 37.36  ? 673  ARG A CA  1 
ATOM   2914 C  C   . ARG A 1 410 ? 8.360   -32.574 -34.644 1.00 36.10  ? 673  ARG A C   1 
ATOM   2915 O  O   . ARG A 1 410 ? 8.786   -31.797 -33.779 1.00 37.19  ? 673  ARG A O   1 
ATOM   2916 C  CB  . ARG A 1 410 ? 9.326   -31.989 -36.864 1.00 43.59  ? 673  ARG A CB  1 
ATOM   2917 C  CG  . ARG A 1 410 ? 10.435  -32.148 -37.896 1.00 45.59  ? 673  ARG A CG  1 
ATOM   2918 C  CD  . ARG A 1 410 ? 10.264  -31.116 -38.993 1.00 42.89  ? 673  ARG A CD  1 
ATOM   2919 N  NE  . ARG A 1 410 ? 9.145   -31.484 -39.839 1.00 44.85  ? 673  ARG A NE  1 
ATOM   2920 C  CZ  . ARG A 1 410 ? 8.603   -30.721 -40.780 1.00 50.39  ? 673  ARG A CZ  1 
ATOM   2921 N  NH1 . ARG A 1 410 ? 9.077   -29.510 -41.006 1.00 48.33  ? 673  ARG A NH1 1 
ATOM   2922 N  NH2 . ARG A 1 410 ? 7.579   -31.172 -41.489 1.00 49.81  ? 673  ARG A NH2 1 
ATOM   2923 N  N   . PHE A 1 411 ? 7.079   -32.959 -34.707 1.00 38.09  ? 674  PHE A N   1 
ATOM   2924 C  CA  . PHE A 1 411 ? 6.035   -32.682 -33.686 1.00 30.10  ? 674  PHE A CA  1 
ATOM   2925 C  C   . PHE A 1 411 ? 6.533   -33.015 -32.271 1.00 29.38  ? 674  PHE A C   1 
ATOM   2926 O  O   . PHE A 1 411 ? 6.230   -32.230 -31.348 1.00 33.28  ? 674  PHE A O   1 
ATOM   2927 C  CB  . PHE A 1 411 ? 4.795   -33.522 -34.021 1.00 35.24  ? 674  PHE A CB  1 
ATOM   2928 C  CG  . PHE A 1 411 ? 3.593   -33.340 -33.132 1.00 32.55  ? 674  PHE A CG  1 
ATOM   2929 C  CD1 . PHE A 1 411 ? 3.410   -34.139 -32.017 1.00 34.81  ? 674  PHE A CD1 1 
ATOM   2930 C  CD2 . PHE A 1 411 ? 2.608   -32.422 -33.458 1.00 33.22  ? 674  PHE A CD2 1 
ATOM   2931 C  CE1 . PHE A 1 411 ? 2.261   -34.006 -31.243 1.00 31.46  ? 674  PHE A CE1 1 
ATOM   2932 C  CE2 . PHE A 1 411 ? 1.476   -32.268 -32.668 1.00 31.22  ? 674  PHE A CE2 1 
ATOM   2933 C  CZ  . PHE A 1 411 ? 1.311   -33.045 -31.548 1.00 29.13  ? 674  PHE A CZ  1 
ATOM   2934 N  N   . ALA A 1 412 ? 7.263   -34.131 -32.095 1.00 32.74  ? 675  ALA A N   1 
ATOM   2935 C  CA  . ALA A 1 412 ? 7.730   -34.674 -30.792 1.00 32.10  ? 675  ALA A CA  1 
ATOM   2936 C  C   . ALA A 1 412 ? 8.520   -33.637 -29.977 1.00 34.78  ? 675  ALA A C   1 
ATOM   2937 O  O   . ALA A 1 412 ? 8.391   -33.624 -28.733 1.00 32.46  ? 675  ALA A O   1 
ATOM   2938 C  CB  . ALA A 1 412 ? 8.555   -35.919 -31.040 1.00 32.68  ? 675  ALA A CB  1 
ATOM   2939 N  N   . SER A 1 413 ? 9.308   -32.787 -30.642 1.00 36.20  ? 676  SER A N   1 
ATOM   2940 C  CA  . SER A 1 413 ? 10.139  -31.752 -29.975 1.00 41.09  ? 676  SER A CA  1 
ATOM   2941 C  C   . SER A 1 413 ? 9.605   -30.341 -30.246 1.00 43.42  ? 676  SER A C   1 
ATOM   2942 O  O   . SER A 1 413 ? 10.264  -29.401 -29.805 1.00 44.80  ? 676  SER A O   1 
ATOM   2943 C  CB  . SER A 1 413 ? 11.608  -31.886 -30.349 1.00 40.91  ? 676  SER A CB  1 
ATOM   2944 O  OG  . SER A 1 413 ? 11.750  -32.157 -31.734 1.00 45.55  ? 676  SER A OG  1 
ATOM   2945 N  N   . ALA A 1 414 ? 8.427   -30.178 -30.863 1.00 43.38  ? 677  ALA A N   1 
ATOM   2946 C  CA  . ALA A 1 414 ? 7.786   -28.850 -31.052 1.00 39.76  ? 677  ALA A CA  1 
ATOM   2947 C  C   . ALA A 1 414 ? 7.035   -28.489 -29.771 1.00 42.79  ? 677  ALA A C   1 
ATOM   2948 O  O   . ALA A 1 414 ? 5.818   -28.852 -29.674 1.00 42.78  ? 677  ALA A O   1 
ATOM   2949 C  CB  . ALA A 1 414 ? 6.865   -28.873 -32.249 1.00 41.75  ? 677  ALA A CB  1 
ATOM   2950 N  N   . LEU A 1 415 ? 7.701   -27.831 -28.817 1.00 36.04  ? 678  LEU A N   1 
ATOM   2951 C  CA  . LEU A 1 415 ? 7.203   -27.722 -27.422 1.00 38.07  ? 678  LEU A CA  1 
ATOM   2952 C  C   . LEU A 1 415 ? 6.992   -26.270 -26.980 1.00 41.55  ? 678  LEU A C   1 
ATOM   2953 O  O   . LEU A 1 415 ? 6.367   -26.090 -25.914 1.00 44.03  ? 678  LEU A O   1 
ATOM   2954 C  CB  . LEU A 1 415 ? 8.159   -28.441 -26.468 1.00 37.55  ? 678  LEU A CB  1 
ATOM   2955 C  CG  . LEU A 1 415 ? 8.269   -29.963 -26.646 1.00 42.99  ? 678  LEU A CG  1 
ATOM   2956 C  CD1 . LEU A 1 415 ? 9.438   -30.549 -25.837 1.00 39.29  ? 678  LEU A CD1 1 
ATOM   2957 C  CD2 . LEU A 1 415 ? 6.961   -30.659 -26.273 1.00 43.53  ? 678  LEU A CD2 1 
ATOM   2958 N  N   . THR A 1 416 ? 7.429   -25.263 -27.739 1.00 43.01  ? 679  THR A N   1 
ATOM   2959 C  CA  . THR A 1 416 ? 7.518   -23.876 -27.198 1.00 44.89  ? 679  THR A CA  1 
ATOM   2960 C  C   . THR A 1 416 ? 6.102   -23.291 -27.069 1.00 42.29  ? 679  THR A C   1 
ATOM   2961 O  O   . THR A 1 416 ? 5.776   -22.744 -25.981 1.00 40.28  ? 679  THR A O   1 
ATOM   2962 C  CB  . THR A 1 416 ? 8.487   -23.009 -28.014 1.00 52.36  ? 679  THR A CB  1 
ATOM   2963 O  OG1 . THR A 1 416 ? 8.018   -22.862 -29.351 1.00 57.28  ? 679  THR A OG1 1 
ATOM   2964 C  CG2 . THR A 1 416 ? 9.879   -23.602 -28.083 1.00 55.19  ? 679  THR A CG2 1 
ATOM   2965 N  N   . ALA A 1 417 ? 5.264   -23.403 -28.104 1.00 41.75  ? 680  ALA A N   1 
ATOM   2966 C  CA  . ALA A 1 417 ? 3.869   -22.879 -28.051 1.00 40.28  ? 680  ALA A CA  1 
ATOM   2967 C  C   . ALA A 1 417 ? 3.067   -23.626 -26.974 1.00 42.67  ? 680  ALA A C   1 
ATOM   2968 O  O   . ALA A 1 417 ? 2.420   -22.954 -26.127 1.00 43.59  ? 680  ALA A O   1 
ATOM   2969 C  CB  . ALA A 1 417 ? 3.232   -22.936 -29.416 1.00 41.66  ? 680  ALA A CB  1 
ATOM   2970 N  N   . LEU A 1 418 ? 3.137   -24.964 -26.967 1.00 42.91  ? 681  LEU A N   1 
ATOM   2971 C  CA  . LEU A 1 418 ? 2.391   -25.829 -26.012 1.00 39.32  ? 681  LEU A CA  1 
ATOM   2972 C  C   . LEU A 1 418 ? 2.720   -25.409 -24.579 1.00 41.90  ? 681  LEU A C   1 
ATOM   2973 O  O   . LEU A 1 418 ? 1.779   -25.141 -23.811 1.00 43.88  ? 681  LEU A O   1 
ATOM   2974 C  CB  . LEU A 1 418 ? 2.791   -27.282 -26.264 1.00 41.81  ? 681  LEU A CB  1 
ATOM   2975 C  CG  . LEU A 1 418 ? 1.984   -28.338 -25.517 1.00 44.84  ? 681  LEU A CG  1 
ATOM   2976 C  CD1 . LEU A 1 418 ? 0.542   -28.380 -26.025 1.00 42.24  ? 681  LEU A CD1 1 
ATOM   2977 C  CD2 . LEU A 1 418 ? 2.648   -29.694 -25.685 1.00 42.25  ? 681  LEU A CD2 1 
ATOM   2978 N  N   . ASN A 1 419 ? 4.013   -25.341 -24.236 1.00 42.16  ? 682  ASN A N   1 
ATOM   2979 C  CA  . ASN A 1 419 ? 4.470   -24.912 -22.890 1.00 42.15  ? 682  ASN A CA  1 
ATOM   2980 C  C   . ASN A 1 419 ? 4.033   -23.462 -22.625 1.00 43.73  ? 682  ASN A C   1 
ATOM   2981 O  O   . ASN A 1 419 ? 3.505   -23.222 -21.522 1.00 46.56  ? 682  ASN A O   1 
ATOM   2982 C  CB  . ASN A 1 419 ? 5.976   -25.103 -22.727 1.00 47.03  ? 682  ASN A CB  1 
ATOM   2983 C  CG  . ASN A 1 419 ? 6.364   -26.554 -22.530 1.00 46.12  ? 682  ASN A CG  1 
ATOM   2984 O  OD1 . ASN A 1 419 ? 5.598   -27.335 -21.963 1.00 46.16  ? 682  ASN A OD1 1 
ATOM   2985 N  ND2 . ASN A 1 419 ? 7.537   -26.922 -23.016 1.00 41.38  ? 682  ASN A ND2 1 
ATOM   2986 N  N   . ASP A 1 420 ? 4.193   -22.545 -23.590 1.00 40.44  ? 683  ASP A N   1 
ATOM   2987 C  CA  . ASP A 1 420 ? 3.845   -21.103 -23.420 1.00 45.42  ? 683  ASP A CA  1 
ATOM   2988 C  C   . ASP A 1 420 ? 2.319   -20.887 -23.370 1.00 43.16  ? 683  ASP A C   1 
ATOM   2989 O  O   . ASP A 1 420 ? 1.909   -19.927 -22.725 1.00 43.76  ? 683  ASP A O   1 
ATOM   2990 C  CB  . ASP A 1 420 ? 4.418   -20.216 -24.531 1.00 44.48  ? 683  ASP A CB  1 
ATOM   2991 C  CG  . ASP A 1 420 ? 4.249   -18.726 -24.247 1.00 47.20  ? 683  ASP A CG  1 
ATOM   2992 O  OD1 . ASP A 1 420 ? 4.498   -18.324 -23.086 1.00 43.49  ? 683  ASP A OD1 1 
ATOM   2993 O  OD2 . ASP A 1 420 ? 3.849   -17.971 -25.183 1.00 45.19  ? 683  ASP A OD2 1 
ATOM   2994 N  N   . MET A 1 421 ? 1.501   -21.734 -24.005 1.00 42.78  ? 684  MET A N   1 
ATOM   2995 C  CA  . MET A 1 421 ? 0.015   -21.690 -23.840 1.00 40.43  ? 684  MET A CA  1 
ATOM   2996 C  C   . MET A 1 421 ? -0.346  -22.205 -22.443 1.00 41.51  ? 684  MET A C   1 
ATOM   2997 O  O   . MET A 1 421 ? -1.534  -22.134 -22.078 1.00 41.07  ? 684  MET A O   1 
ATOM   2998 C  CB  . MET A 1 421 ? -0.698  -22.525 -24.906 1.00 43.47  ? 684  MET A CB  1 
ATOM   2999 C  CG  . MET A 1 421 ? -0.613  -21.923 -26.297 1.00 41.61  ? 684  MET A CG  1 
ATOM   3000 S  SD  . MET A 1 421 ? -1.448  -22.914 -27.570 1.00 50.08  ? 684  MET A SD  1 
ATOM   3001 C  CE  . MET A 1 421 ? -0.448  -24.393 -27.627 1.00 51.31  ? 684  MET A CE  1 
ATOM   3002 N  N   . GLY A 1 422 ? 0.633   -22.749 -21.706 1.00 40.09  ? 685  GLY A N   1 
ATOM   3003 C  CA  . GLY A 1 422 ? 0.435   -23.303 -20.350 1.00 37.63  ? 685  GLY A CA  1 
ATOM   3004 C  C   . GLY A 1 422 ? -0.093  -24.729 -20.317 1.00 39.69  ? 685  GLY A C   1 
ATOM   3005 O  O   . GLY A 1 422 ? -0.363  -25.193 -19.188 1.00 38.82  ? 685  GLY A O   1 
ATOM   3006 N  N   . LYS A 1 423 ? -0.194  -25.417 -21.466 1.00 37.43  ? 686  LYS A N   1 
ATOM   3007 C  CA  . LYS A 1 423 ? -0.627  -26.850 -21.581 1.00 40.11  ? 686  LYS A CA  1 
ATOM   3008 C  C   . LYS A 1 423 ? 0.569   -27.800 -21.389 1.00 42.70  ? 686  LYS A C   1 
ATOM   3009 O  O   . LYS A 1 423 ? 0.894   -28.612 -22.303 1.00 39.95  ? 686  LYS A O   1 
ATOM   3010 C  CB  . LYS A 1 423 ? -1.341  -27.067 -22.920 1.00 36.72  ? 686  LYS A CB  1 
ATOM   3011 C  CG  . LYS A 1 423 ? -2.547  -26.157 -23.115 1.00 38.60  ? 686  LYS A CG  1 
ATOM   3012 C  CD  . LYS A 1 423 ? -3.435  -26.082 -21.868 1.00 43.09  ? 686  LYS A CD  1 
ATOM   3013 C  CE  . LYS A 1 423 ? -4.672  -25.217 -22.029 1.00 45.71  ? 686  LYS A CE  1 
ATOM   3014 N  NZ  . LYS A 1 423 ? -4.325  -23.775 -22.087 1.00 46.37  ? 686  LYS A NZ  1 
ATOM   3015 N  N   . VAL A 1 424 ? 1.147   -27.755 -20.194 1.00 46.12  ? 687  VAL A N   1 
ATOM   3016 C  CA  . VAL A 1 424 ? 2.384   -28.498 -19.821 1.00 46.01  ? 687  VAL A CA  1 
ATOM   3017 C  C   . VAL A 1 424 ? 2.031   -29.981 -19.757 1.00 40.55  ? 687  VAL A C   1 
ATOM   3018 O  O   . VAL A 1 424 ? 1.012   -30.311 -19.094 1.00 40.66  ? 687  VAL A O   1 
ATOM   3019 C  CB  . VAL A 1 424 ? 2.939   -27.960 -18.485 1.00 50.44  ? 687  VAL A CB  1 
ATOM   3020 C  CG1 . VAL A 1 424 ? 3.819   -28.962 -17.756 1.00 53.37  ? 687  VAL A CG1 1 
ATOM   3021 C  CG2 . VAL A 1 424 ? 3.682   -26.652 -18.696 1.00 49.84  ? 687  VAL A CG2 1 
ATOM   3022 N  N   . ARG A 1 425 ? 2.840   -30.831 -20.399 1.00 37.61  ? 688  ARG A N   1 
ATOM   3023 C  CA  . ARG A 1 425 ? 2.604   -32.294 -20.461 1.00 38.24  ? 688  ARG A CA  1 
ATOM   3024 C  C   . ARG A 1 425 ? 2.831   -32.906 -19.077 1.00 41.48  ? 688  ARG A C   1 
ATOM   3025 O  O   . ARG A 1 425 ? 3.684   -32.397 -18.313 1.00 46.29  ? 688  ARG A O   1 
ATOM   3026 C  CB  . ARG A 1 425 ? 3.478   -32.966 -21.518 1.00 36.94  ? 688  ARG A CB  1 
ATOM   3027 C  CG  . ARG A 1 425 ? 3.245   -32.449 -22.924 1.00 39.04  ? 688  ARG A CG  1 
ATOM   3028 C  CD  . ARG A 1 425 ? 4.397   -32.800 -23.829 1.00 41.61  ? 688  ARG A CD  1 
ATOM   3029 N  NE  . ARG A 1 425 ? 5.656   -32.223 -23.359 1.00 45.57  ? 688  ARG A NE  1 
ATOM   3030 C  CZ  . ARG A 1 425 ? 6.876   -32.687 -23.655 1.00 43.40  ? 688  ARG A CZ  1 
ATOM   3031 N  NH1 . ARG A 1 425 ? 7.035   -33.739 -24.445 1.00 41.71  ? 688  ARG A NH1 1 
ATOM   3032 N  NH2 . ARG A 1 425 ? 7.937   -32.073 -23.164 1.00 43.62  ? 688  ARG A NH2 1 
ATOM   3033 N  N   . LYS A 1 426 ? 2.108   -33.993 -18.781 0.34 42.44  ? 689  LYS A N   1 
ATOM   3034 C  CA  . LYS A 1 426 ? 2.202   -34.775 -17.518 0.34 43.77  ? 689  LYS A CA  1 
ATOM   3035 C  C   . LYS A 1 426 ? 3.251   -35.887 -17.672 0.34 44.89  ? 689  LYS A C   1 
ATOM   3036 O  O   . LYS A 1 426 ? 3.458   -36.357 -18.810 0.34 44.86  ? 689  LYS A O   1 
ATOM   3037 C  CB  . LYS A 1 426 ? 0.830   -35.362 -17.169 0.34 44.90  ? 689  LYS A CB  1 
ATOM   3038 C  CG  . LYS A 1 426 ? 0.732   -36.019 -15.798 0.34 45.96  ? 689  LYS A CG  1 
ATOM   3039 C  CD  . LYS A 1 426 ? -0.687  -36.175 -15.293 0.34 46.49  ? 689  LYS A CD  1 
ATOM   3040 C  CE  . LYS A 1 426 ? -1.568  -36.972 -16.230 0.34 47.58  ? 689  LYS A CE  1 
ATOM   3041 N  NZ  . LYS A 1 426 ? -2.965  -37.036 -15.741 0.34 48.77  ? 689  LYS A NZ  1 
ATOM   3042 N  N   . ASP A 1 427 ? 3.895   -36.276 -16.566 0.34 45.80  ? 690  ASP A N   1 
ATOM   3043 C  CA  . ASP A 1 427 ? 4.787   -37.464 -16.462 0.34 45.47  ? 690  ASP A CA  1 
ATOM   3044 C  C   . ASP A 1 427 ? 5.982   -37.342 -17.418 0.34 46.04  ? 690  ASP A C   1 
ATOM   3045 O  O   . ASP A 1 427 ? 6.371   -38.382 -17.997 0.34 47.56  ? 690  ASP A O   1 
ATOM   3046 C  CB  . ASP A 1 427 ? 4.037   -38.758 -16.789 0.34 45.56  ? 690  ASP A CB  1 
ATOM   3047 C  CG  . ASP A 1 427 ? 2.802   -39.001 -15.941 0.34 45.44  ? 690  ASP A CG  1 
ATOM   3048 O  OD1 . ASP A 1 427 ? 2.813   -38.598 -14.763 0.34 48.08  ? 690  ASP A OD1 1 
ATOM   3049 O  OD2 . ASP A 1 427 ? 1.837   -39.588 -16.470 0.34 43.36  ? 690  ASP A OD2 1 
ATOM   3050 N  N   . ILE A 1 428 ? 6.541   -36.138 -17.579 0.34 44.13  ? 691  ILE A N   1 
ATOM   3051 C  CA  . ILE A 1 428 ? 7.743   -35.883 -18.427 0.34 43.82  ? 691  ILE A CA  1 
ATOM   3052 C  C   . ILE A 1 428 ? 8.282   -34.484 -18.115 0.34 44.23  ? 691  ILE A C   1 
ATOM   3053 O  O   . ILE A 1 428 ? 7.523   -33.672 -17.549 0.34 40.62  ? 691  ILE A O   1 
ATOM   3054 C  CB  . ILE A 1 428 ? 7.421   -36.052 -19.926 0.34 44.41  ? 691  ILE A CB  1 
ATOM   3055 C  CG1 . ILE A 1 428 ? 8.694   -36.039 -20.777 0.34 44.30  ? 691  ILE A CG1 1 
ATOM   3056 C  CG2 . ILE A 1 428 ? 6.425   -35.002 -20.391 0.34 44.62  ? 691  ILE A CG2 1 
ATOM   3057 C  CD1 . ILE A 1 428 ? 8.530   -36.665 -22.145 0.34 43.45  ? 691  ILE A CD1 1 
ATOM   3058 N  N   . GLN A 1 429 ? 9.537   -34.228 -18.506 0.34 46.43  ? 692  GLN A N   1 
ATOM   3059 C  CA  . GLN A 1 429 ? 10.183  -32.907 -18.283 0.34 49.13  ? 692  GLN A CA  1 
ATOM   3060 C  C   . GLN A 1 429 ? 9.687   -31.917 -19.337 0.34 47.44  ? 692  GLN A C   1 
ATOM   3061 O  O   . GLN A 1 429 ? 9.518   -32.334 -20.495 0.34 44.95  ? 692  GLN A O   1 
ATOM   3062 C  CB  . GLN A 1 429 ? 11.703  -33.050 -18.339 0.34 53.15  ? 692  GLN A CB  1 
ATOM   3063 C  CG  . GLN A 1 429 ? 12.292  -33.745 -17.121 0.34 57.54  ? 692  GLN A CG  1 
ATOM   3064 C  CD  . GLN A 1 429 ? 12.095  -32.931 -15.866 0.34 60.83  ? 692  GLN A CD  1 
ATOM   3065 O  OE1 . GLN A 1 429 ? 11.534  -33.401 -14.879 0.34 61.85  ? 692  GLN A OE1 1 
ATOM   3066 N  NE2 . GLN A 1 429 ? 12.558  -31.692 -15.899 0.34 62.70  ? 692  GLN A NE2 1 
ATOM   3067 N  N   . GLN A 1 430 ? 9.526   -30.648 -18.961 0.34 49.31  ? 693  GLN A N   1 
ATOM   3068 C  CA  . GLN A 1 430 ? 8.933   -29.631 -19.873 0.34 50.73  ? 693  GLN A CA  1 
ATOM   3069 C  C   . GLN A 1 430 ? 9.587   -29.652 -21.255 0.34 50.62  ? 693  GLN A C   1 
ATOM   3070 O  O   . GLN A 1 430 ? 8.855   -29.478 -22.243 0.34 50.01  ? 693  GLN A O   1 
ATOM   3071 C  CB  . GLN A 1 430 ? 9.081   -28.241 -19.252 0.34 51.44  ? 693  GLN A CB  1 
ATOM   3072 C  CG  . GLN A 1 430 ? 7.891   -27.330 -19.506 0.34 52.24  ? 693  GLN A CG  1 
ATOM   3073 C  CD  . GLN A 1 430 ? 8.218   -25.887 -19.213 0.34 51.98  ? 693  GLN A CD  1 
ATOM   3074 O  OE1 . GLN A 1 430 ? 9.376   -25.517 -19.040 0.34 50.63  ? 693  GLN A OE1 1 
ATOM   3075 N  NE2 . GLN A 1 430 ? 7.190   -25.057 -19.155 0.34 51.17  ? 693  GLN A NE2 1 
ATOM   3076 N  N   . TRP A 1 431 ? 10.902  -29.849 -21.326 1.00 50.92  ? 694  TRP A N   1 
ATOM   3077 C  CA  . TRP A 1 431 ? 11.598  -29.750 -22.637 1.00 47.42  ? 694  TRP A CA  1 
ATOM   3078 C  C   . TRP A 1 431 ? 12.069  -31.118 -23.142 1.00 46.86  ? 694  TRP A C   1 
ATOM   3079 O  O   . TRP A 1 431 ? 12.773  -31.144 -24.156 1.00 46.63  ? 694  TRP A O   1 
ATOM   3080 C  CB  . TRP A 1 431 ? 12.724  -28.723 -22.534 1.00 56.79  ? 694  TRP A CB  1 
ATOM   3081 C  CG  . TRP A 1 431 ? 12.212  -27.375 -22.130 1.00 58.26  ? 694  TRP A CG  1 
ATOM   3082 C  CD1 . TRP A 1 431 ? 12.405  -26.741 -20.939 1.00 57.30  ? 694  TRP A CD1 1 
ATOM   3083 C  CD2 . TRP A 1 431 ? 11.376  -26.507 -22.914 1.00 56.87  ? 694  TRP A CD2 1 
ATOM   3084 N  NE1 . TRP A 1 431 ? 11.763  -25.533 -20.934 1.00 59.28  ? 694  TRP A NE1 1 
ATOM   3085 C  CE2 . TRP A 1 431 ? 11.122  -25.362 -22.131 1.00 57.47  ? 694  TRP A CE2 1 
ATOM   3086 C  CE3 . TRP A 1 431 ? 10.828  -26.581 -24.198 1.00 55.85  ? 694  TRP A CE3 1 
ATOM   3087 C  CZ2 . TRP A 1 431 ? 10.342  -24.305 -22.594 1.00 56.58  ? 694  TRP A CZ2 1 
ATOM   3088 C  CZ3 . TRP A 1 431 ? 10.059  -25.535 -24.655 1.00 59.42  ? 694  TRP A CZ3 1 
ATOM   3089 C  CH2 . TRP A 1 431 ? 9.821   -24.414 -23.861 1.00 60.16  ? 694  TRP A CH2 1 
ATOM   3090 N  N   . GLU A 1 432 ? 11.657  -32.199 -22.480 0.34 45.83  ? 695  GLU A N   1 
ATOM   3091 C  CA  . GLU A 1 432 ? 11.994  -33.557 -22.975 0.34 45.89  ? 695  GLU A CA  1 
ATOM   3092 C  C   . GLU A 1 432 ? 11.027  -33.912 -24.108 0.34 45.28  ? 695  GLU A C   1 
ATOM   3093 O  O   . GLU A 1 432 ? 9.808   -33.789 -23.912 0.34 43.48  ? 695  GLU A O   1 
ATOM   3094 C  CB  . GLU A 1 432 ? 11.929  -34.576 -21.838 0.34 46.12  ? 695  GLU A CB  1 
ATOM   3095 C  CG  . GLU A 1 432 ? 12.403  -35.959 -22.240 0.34 46.43  ? 695  GLU A CG  1 
ATOM   3096 C  CD  . GLU A 1 432 ? 13.870  -36.032 -22.628 0.34 47.42  ? 695  GLU A CD  1 
ATOM   3097 O  OE1 . GLU A 1 432 ? 14.223  -36.920 -23.428 0.34 45.45  ? 695  GLU A OE1 1 
ATOM   3098 O  OE2 . GLU A 1 432 ? 14.654  -35.200 -22.130 0.34 49.33  ? 695  GLU A OE2 1 
ATOM   3099 N  N   . PRO A 1 433 ? 11.525  -34.336 -25.285 1.00 45.19  ? 696  PRO A N   1 
ATOM   3100 C  CA  . PRO A 1 433 ? 10.666  -34.656 -26.421 1.00 40.94  ? 696  PRO A CA  1 
ATOM   3101 C  C   . PRO A 1 433 ? 9.637   -35.764 -26.157 1.00 40.28  ? 696  PRO A C   1 
ATOM   3102 O  O   . PRO A 1 433 ? 9.955   -36.685 -25.459 1.00 37.98  ? 696  PRO A O   1 
ATOM   3103 C  CB  . PRO A 1 433 ? 11.654  -35.100 -27.504 1.00 46.07  ? 696  PRO A CB  1 
ATOM   3104 C  CG  . PRO A 1 433 ? 12.956  -34.448 -27.105 1.00 47.12  ? 696  PRO A CG  1 
ATOM   3105 C  CD  . PRO A 1 433 ? 12.942  -34.500 -25.595 1.00 46.06  ? 696  PRO A CD  1 
ATOM   3106 N  N   . SER A 1 434 ? 8.441   -35.628 -26.736 1.00 37.58  ? 697  SER A N   1 
ATOM   3107 C  CA  . SER A 1 434 ? 7.351   -36.606 -26.547 1.00 36.68  ? 697  SER A CA  1 
ATOM   3108 C  C   . SER A 1 434 ? 7.772   -37.978 -27.086 1.00 38.35  ? 697  SER A C   1 
ATOM   3109 O  O   . SER A 1 434 ? 8.409   -38.048 -28.130 1.00 44.99  ? 697  SER A O   1 
ATOM   3110 C  CB  . SER A 1 434 ? 6.107   -36.153 -27.281 1.00 32.38  ? 697  SER A CB  1 
ATOM   3111 O  OG  . SER A 1 434 ? 5.532   -35.043 -26.654 1.00 31.90  ? 697  SER A OG  1 
ATOM   3112 N  N   . ARG A 1 435 ? 7.420   -39.036 -26.347 0.34 39.62  ? 698  ARG A N   1 
ATOM   3113 C  CA  . ARG A 1 435 ? 7.443   -40.455 -26.795 0.34 42.09  ? 698  ARG A CA  1 
ATOM   3114 C  C   . ARG A 1 435 ? 6.164   -40.730 -27.593 0.34 42.90  ? 698  ARG A C   1 
ATOM   3115 O  O   . ARG A 1 435 ? 5.074   -40.556 -27.017 0.34 42.25  ? 698  ARG A O   1 
ATOM   3116 C  CB  . ARG A 1 435 ? 7.495   -41.413 -25.598 0.34 42.89  ? 698  ARG A CB  1 
ATOM   3117 C  CG  . ARG A 1 435 ? 8.888   -41.667 -25.038 0.34 45.36  ? 698  ARG A CG  1 
ATOM   3118 C  CD  . ARG A 1 435 ? 8.874   -42.693 -23.914 0.34 46.09  ? 698  ARG A CD  1 
ATOM   3119 N  NE  . ARG A 1 435 ? 8.387   -42.137 -22.659 0.34 47.09  ? 698  ARG A NE  1 
ATOM   3120 C  CZ  . ARG A 1 435 ? 9.148   -41.894 -21.596 0.34 47.51  ? 698  ARG A CZ  1 
ATOM   3121 N  NH1 . ARG A 1 435 ? 10.441  -42.173 -21.629 0.34 47.92  ? 698  ARG A NH1 1 
ATOM   3122 N  NH2 . ARG A 1 435 ? 8.614   -41.376 -20.503 0.34 45.72  ? 698  ARG A NH2 1 
ATOM   3123 N  N   . GLY A 1 436 ? 6.288   -41.118 -28.864 1.00 42.66  ? 699  GLY A N   1 
ATOM   3124 C  CA  . GLY A 1 436 ? 5.134   -41.523 -29.681 1.00 43.65  ? 699  GLY A CA  1 
ATOM   3125 C  C   . GLY A 1 436 ? 4.954   -43.033 -29.676 1.00 42.39  ? 699  GLY A C   1 
ATOM   3126 O  O   . GLY A 1 436 ? 5.829   -43.743 -29.185 1.00 43.48  ? 699  GLY A O   1 
ATOM   3127 N  N   . TRP A 1 437 ? 3.840   -43.497 -30.220 1.00 36.88  ? 700  TRP A N   1 
ATOM   3128 C  CA  . TRP A 1 437 ? 3.466   -44.918 -30.292 1.00 32.62  ? 700  TRP A CA  1 
ATOM   3129 C  C   . TRP A 1 437 ? 3.581   -45.315 -31.749 1.00 33.03  ? 700  TRP A C   1 
ATOM   3130 O  O   . TRP A 1 437 ? 3.178   -44.511 -32.594 1.00 32.17  ? 700  TRP A O   1 
ATOM   3131 C  CB  . TRP A 1 437 ? 2.042   -45.082 -29.778 1.00 33.24  ? 700  TRP A CB  1 
ATOM   3132 C  CG  . TRP A 1 437 ? 1.850   -44.624 -28.375 1.00 29.35  ? 700  TRP A CG  1 
ATOM   3133 C  CD1 . TRP A 1 437 ? 1.528   -43.384 -27.910 1.00 32.90  ? 700  TRP A CD1 1 
ATOM   3134 C  CD2 . TRP A 1 437 ? 1.990   -45.454 -27.227 1.00 29.53  ? 700  TRP A CD2 1 
ATOM   3135 N  NE1 . TRP A 1 437 ? 1.482   -43.387 -26.541 1.00 29.92  ? 700  TRP A NE1 1 
ATOM   3136 C  CE2 . TRP A 1 437 ? 1.739   -44.650 -26.102 1.00 28.68  ? 700  TRP A CE2 1 
ATOM   3137 C  CE3 . TRP A 1 437 ? 2.334   -46.783 -27.071 1.00 29.46  ? 700  TRP A CE3 1 
ATOM   3138 C  CZ2 . TRP A 1 437 ? 1.808   -45.147 -24.818 1.00 27.76  ? 700  TRP A CZ2 1 
ATOM   3139 C  CZ3 . TRP A 1 437 ? 2.394   -47.274 -25.803 1.00 30.93  ? 700  TRP A CZ3 1 
ATOM   3140 C  CH2 . TRP A 1 437 ? 2.123   -46.470 -24.706 1.00 29.88  ? 700  TRP A CH2 1 
ATOM   3141 N  N   . ASN A 1 438 ? 4.106   -46.490 -32.038 1.00 33.49  ? 701  ASN A N   1 
ATOM   3142 C  CA  . ASN A 1 438 ? 4.228   -46.949 -33.444 1.00 38.99  ? 701  ASN A CA  1 
ATOM   3143 C  C   . ASN A 1 438 ? 3.049   -47.817 -33.838 1.00 39.59  ? 701  ASN A C   1 
ATOM   3144 O  O   . ASN A 1 438 ? 2.936   -48.077 -35.040 1.00 41.32  ? 701  ASN A O   1 
ATOM   3145 C  CB  . ASN A 1 438 ? 5.513   -47.742 -33.672 1.00 44.03  ? 701  ASN A CB  1 
ATOM   3146 C  CG  . ASN A 1 438 ? 6.706   -46.856 -33.417 1.00 49.06  ? 701  ASN A CG  1 
ATOM   3147 O  OD1 . ASN A 1 438 ? 7.486   -47.109 -32.489 1.00 62.31  ? 701  ASN A OD1 1 
ATOM   3148 N  ND2 . ASN A 1 438 ? 6.768   -45.770 -34.175 1.00 42.95  ? 701  ASN A ND2 1 
ATOM   3149 N  N   . ASP A 1 439 ? 2.240   -48.261 -32.876 1.00 41.54  ? 702  ASP A N   1 
ATOM   3150 C  CA  . ASP A 1 439 ? 1.108   -49.187 -33.164 1.00 45.96  ? 702  ASP A CA  1 
ATOM   3151 C  C   . ASP A 1 439 ? -0.200  -48.576 -32.623 1.00 39.25  ? 702  ASP A C   1 
ATOM   3152 O  O   . ASP A 1 439 ? -0.300  -48.317 -31.405 1.00 37.19  ? 702  ASP A O   1 
ATOM   3153 C  CB  . ASP A 1 439 ? 1.522   -50.562 -32.635 1.00 48.61  ? 702  ASP A CB  1 
ATOM   3154 C  CG  . ASP A 1 439 ? 0.488   -51.669 -32.681 1.00 58.09  ? 702  ASP A CG  1 
ATOM   3155 O  OD1 . ASP A 1 439 ? -0.621  -51.454 -33.271 1.00 53.52  ? 702  ASP A OD1 1 
ATOM   3156 O  OD2 . ASP A 1 439 ? 0.819   -52.761 -32.127 1.00 62.13  ? 702  ASP A OD2 1 
ATOM   3157 N  N   . TRP A 1 440 ? -1.198  -48.372 -33.473 1.00 35.35  ? 703  TRP A N   1 
ATOM   3158 C  CA  . TRP A 1 440 ? -2.498  -47.800 -33.025 1.00 35.21  ? 703  TRP A CA  1 
ATOM   3159 C  C   . TRP A 1 440 ? -3.146  -48.664 -31.920 1.00 32.79  ? 703  TRP A C   1 
ATOM   3160 O  O   . TRP A 1 440 ? -3.891  -48.111 -31.088 1.00 34.59  ? 703  TRP A O   1 
ATOM   3161 C  CB  . TRP A 1 440 ? -3.417  -47.530 -34.212 1.00 36.24  ? 703  TRP A CB  1 
ATOM   3162 C  CG  . TRP A 1 440 ? -3.979  -48.764 -34.853 1.00 40.85  ? 703  TRP A CG  1 
ATOM   3163 C  CD1 . TRP A 1 440 ? -3.477  -49.431 -35.930 1.00 41.19  ? 703  TRP A CD1 1 
ATOM   3164 C  CD2 . TRP A 1 440 ? -5.157  -49.481 -34.456 1.00 38.21  ? 703  TRP A CD2 1 
ATOM   3165 N  NE1 . TRP A 1 440 ? -4.260  -50.509 -36.228 1.00 40.82  ? 703  TRP A NE1 1 
ATOM   3166 C  CE2 . TRP A 1 440 ? -5.287  -50.581 -35.331 1.00 41.80  ? 703  TRP A CE2 1 
ATOM   3167 C  CE3 . TRP A 1 440 ? -6.113  -49.303 -33.455 1.00 35.98  ? 703  TRP A CE3 1 
ATOM   3168 C  CZ2 . TRP A 1 440 ? -6.335  -51.499 -35.239 1.00 38.89  ? 703  TRP A CZ2 1 
ATOM   3169 C  CZ3 . TRP A 1 440 ? -7.137  -50.221 -33.351 1.00 35.15  ? 703  TRP A CZ3 1 
ATOM   3170 C  CH2 . TRP A 1 440 ? -7.247  -51.295 -34.234 1.00 38.59  ? 703  TRP A CH2 1 
ATOM   3171 N  N   . THR A 1 441 ? -2.800  -49.943 -31.802 1.00 33.13  ? 704  THR A N   1 
ATOM   3172 C  CA  . THR A 1 441 ? -3.353  -50.835 -30.747 1.00 32.90  ? 704  THR A CA  1 
ATOM   3173 C  C   . THR A 1 441 ? -2.711  -50.653 -29.360 1.00 33.13  ? 704  THR A C   1 
ATOM   3174 O  O   . THR A 1 441 ? -3.159  -51.294 -28.402 1.00 34.48  ? 704  THR A O   1 
ATOM   3175 C  CB  . THR A 1 441 ? -3.310  -52.298 -31.189 1.00 31.38  ? 704  THR A CB  1 
ATOM   3176 O  OG1 . THR A 1 441 ? -1.955  -52.737 -31.234 1.00 34.96  ? 704  THR A OG1 1 
ATOM   3177 C  CG2 . THR A 1 441 ? -3.966  -52.523 -32.533 1.00 31.17  ? 704  THR A CG2 1 
ATOM   3178 N  N   . GLN A 1 442 ? -1.692  -49.797 -29.251 0.50 34.69  ? 705  GLN A N   1 
ATOM   3179 C  CA  . GLN A 1 442 ? -0.993  -49.483 -27.975 0.50 35.16  ? 705  GLN A CA  1 
ATOM   3180 C  C   . GLN A 1 442 ? -1.359  -48.079 -27.470 0.50 32.56  ? 705  GLN A C   1 
ATOM   3181 O  O   . GLN A 1 442 ? -1.060  -47.794 -26.299 0.50 31.04  ? 705  GLN A O   1 
ATOM   3182 C  CB  . GLN A 1 442 ? 0.516   -49.573 -28.193 0.50 37.96  ? 705  GLN A CB  1 
ATOM   3183 C  CG  . GLN A 1 442 ? 0.943   -50.874 -28.842 0.50 38.55  ? 705  GLN A CG  1 
ATOM   3184 C  CD  . GLN A 1 442 ? 1.476   -51.836 -27.816 0.50 38.93  ? 705  GLN A CD  1 
ATOM   3185 O  OE1 . GLN A 1 442 ? 2.654   -51.802 -27.467 0.50 39.28  ? 705  GLN A OE1 1 
ATOM   3186 N  NE2 . GLN A 1 442 ? 0.602   -52.707 -27.333 0.50 41.90  ? 705  GLN A NE2 1 
ATOM   3187 N  N   . VAL A 1 443 ? -1.943  -47.231 -28.324 1.00 31.55  ? 706  VAL A N   1 
ATOM   3188 C  CA  . VAL A 1 443 ? -2.269  -45.811 -27.987 1.00 34.08  ? 706  VAL A CA  1 
ATOM   3189 C  C   . VAL A 1 443 ? -3.316  -45.784 -26.886 1.00 29.57  ? 706  VAL A C   1 
ATOM   3190 O  O   . VAL A 1 443 ? -4.298  -46.475 -27.003 1.00 33.10  ? 706  VAL A O   1 
ATOM   3191 C  CB  . VAL A 1 443 ? -2.765  -45.037 -29.222 1.00 34.16  ? 706  VAL A CB  1 
ATOM   3192 C  CG1 . VAL A 1 443 ? -3.259  -43.640 -28.881 1.00 39.16  ? 706  VAL A CG1 1 
ATOM   3193 C  CG2 . VAL A 1 443 ? -1.684  -44.962 -30.265 1.00 39.37  ? 706  VAL A CG2 1 
ATOM   3194 N  N   . PRO A 1 444 ? -3.109  -45.028 -25.785 1.00 29.47  ? 707  PRO A N   1 
ATOM   3195 C  CA  . PRO A 1 444 ? -4.153  -44.799 -24.797 1.00 29.08  ? 707  PRO A CA  1 
ATOM   3196 C  C   . PRO A 1 444 ? -5.101  -43.700 -25.288 1.00 31.03  ? 707  PRO A C   1 
ATOM   3197 O  O   . PRO A 1 444 ? -4.632  -42.733 -25.812 1.00 31.27  ? 707  PRO A O   1 
ATOM   3198 C  CB  . PRO A 1 444 ? -3.407  -44.342 -23.547 1.00 32.34  ? 707  PRO A CB  1 
ATOM   3199 C  CG  . PRO A 1 444 ? -2.100  -43.716 -24.087 1.00 31.53  ? 707  PRO A CG  1 
ATOM   3200 C  CD  . PRO A 1 444 ? -1.843  -44.361 -25.441 1.00 31.12  ? 707  PRO A CD  1 
ATOM   3201 N  N   . PHE A 1 445 ? -6.414  -43.873 -25.104 1.00 31.52  ? 708  PHE A N   1 
ATOM   3202 C  CA  . PHE A 1 445 ? -7.436  -42.846 -25.422 1.00 28.61  ? 708  PHE A CA  1 
ATOM   3203 C  C   . PHE A 1 445 ? -8.692  -43.167 -24.628 1.00 29.50  ? 708  PHE A C   1 
ATOM   3204 O  O   . PHE A 1 445 ? -9.077  -44.342 -24.696 1.00 24.69  ? 708  PHE A O   1 
ATOM   3205 C  CB  . PHE A 1 445 ? -7.773  -42.854 -26.916 1.00 31.54  ? 708  PHE A CB  1 
ATOM   3206 C  CG  . PHE A 1 445 ? -8.631  -41.697 -27.383 1.00 33.19  ? 708  PHE A CG  1 
ATOM   3207 C  CD1 . PHE A 1 445 ? -8.313  -40.394 -27.034 1.00 32.34  ? 708  PHE A CD1 1 
ATOM   3208 C  CD2 . PHE A 1 445 ? -9.708  -41.909 -28.231 1.00 34.69  ? 708  PHE A CD2 1 
ATOM   3209 C  CE1 . PHE A 1 445 ? -9.078  -39.328 -27.475 1.00 36.84  ? 708  PHE A CE1 1 
ATOM   3210 C  CE2 . PHE A 1 445 ? -10.447 -40.841 -28.715 1.00 38.76  ? 708  PHE A CE2 1 
ATOM   3211 C  CZ  . PHE A 1 445 ? -10.148 -39.552 -28.312 1.00 38.96  ? 708  PHE A CZ  1 
ATOM   3212 N  N   . CYS A 1 446 ? -9.242  -42.161 -23.931 1.00 30.00  ? 709  CYS A N   1 
ATOM   3213 C  CA  . CYS A 1 446 ? -10.455 -42.181 -23.073 1.00 30.04  ? 709  CYS A CA  1 
ATOM   3214 C  C   . CYS A 1 446 ? -10.396 -43.383 -22.122 1.00 31.08  ? 709  CYS A C   1 
ATOM   3215 O  O   . CYS A 1 446 ? -11.388 -44.186 -22.073 1.00 31.76  ? 709  CYS A O   1 
ATOM   3216 C  CB  . CYS A 1 446 ? -11.698 -42.179 -23.940 1.00 32.20  ? 709  CYS A CB  1 
ATOM   3217 S  SG  . CYS A 1 446 ? -11.793 -40.747 -25.052 1.00 35.67  ? 709  CYS A SG  1 
ATOM   3218 N  N   . SER A 1 447 ? -9.223  -43.572 -21.510 1.00 29.02  ? 710  SER A N   1 
ATOM   3219 C  CA  . SER A 1 447 ? -8.945  -44.588 -20.471 1.00 29.58  ? 710  SER A CA  1 
ATOM   3220 C  C   . SER A 1 447 ? -8.922  -45.992 -21.091 1.00 30.31  ? 710  SER A C   1 
ATOM   3221 O  O   . SER A 1 447 ? -8.951  -46.972 -20.338 1.00 30.59  ? 710  SER A O   1 
ATOM   3222 C  CB  . SER A 1 447 ? -9.971  -44.501 -19.373 1.00 35.73  ? 710  SER A CB  1 
ATOM   3223 O  OG  . SER A 1 447 ? -9.989  -43.204 -18.793 1.00 41.33  ? 710  SER A OG  1 
ATOM   3224 N  N   . HIS A 1 448 ? -8.818  -46.113 -22.407 1.00 29.92  ? 711  HIS A N   1 
ATOM   3225 C  CA  . HIS A 1 448 ? -8.850  -47.427 -23.093 1.00 28.95  ? 711  HIS A CA  1 
ATOM   3226 C  C   . HIS A 1 448 ? -7.644  -47.633 -24.023 1.00 26.99  ? 711  HIS A C   1 
ATOM   3227 O  O   . HIS A 1 448 ? -6.993  -46.660 -24.412 1.00 25.54  ? 711  HIS A O   1 
ATOM   3228 C  CB  . HIS A 1 448 ? -10.153 -47.548 -23.898 1.00 29.16  ? 711  HIS A CB  1 
ATOM   3229 C  CG  . HIS A 1 448 ? -11.337 -47.799 -23.032 1.00 29.66  ? 711  HIS A CG  1 
ATOM   3230 N  ND1 . HIS A 1 448 ? -11.917 -46.796 -22.265 1.00 30.40  ? 711  HIS A ND1 1 
ATOM   3231 C  CD2 . HIS A 1 448 ? -12.021 -48.939 -22.780 1.00 32.46  ? 711  HIS A CD2 1 
ATOM   3232 C  CE1 . HIS A 1 448 ? -12.919 -47.327 -21.569 1.00 32.66  ? 711  HIS A CE1 1 
ATOM   3233 N  NE2 . HIS A 1 448 ? -13.009 -48.653 -21.869 1.00 30.93  ? 711  HIS A NE2 1 
ATOM   3234 N  N   . HIS A 1 449 ? -7.420  -48.886 -24.411 1.00 26.27  ? 712  HIS A N   1 
ATOM   3235 C  CA  . HIS A 1 449 ? -6.702  -49.274 -25.651 1.00 28.24  ? 712  HIS A CA  1 
ATOM   3236 C  C   . HIS A 1 449 ? -7.661  -50.134 -26.468 1.00 27.53  ? 712  HIS A C   1 
ATOM   3237 O  O   . HIS A 1 449 ? -8.710  -50.529 -25.968 1.00 27.99  ? 712  HIS A O   1 
ATOM   3238 C  CB  . HIS A 1 449 ? -5.366  -49.974 -25.358 1.00 24.96  ? 712  HIS A CB  1 
ATOM   3239 C  CG  . HIS A 1 449 ? -5.542  -51.202 -24.538 1.00 24.18  ? 712  HIS A CG  1 
ATOM   3240 N  ND1 . HIS A 1 449 ? -5.721  -51.143 -23.185 1.00 25.31  ? 712  HIS A ND1 1 
ATOM   3241 C  CD2 . HIS A 1 449 ? -5.637  -52.502 -24.872 1.00 24.31  ? 712  HIS A CD2 1 
ATOM   3242 C  CE1 . HIS A 1 449 ? -5.883  -52.362 -22.702 1.00 24.23  ? 712  HIS A CE1 1 
ATOM   3243 N  NE2 . HIS A 1 449 ? -5.844  -53.207 -23.714 1.00 25.35  ? 712  HIS A NE2 1 
ATOM   3244 N  N   . PHE A 1 450 ? -7.287  -50.413 -27.715 0.34 28.44  ? 713  PHE A N   1 
ATOM   3245 C  CA  . PHE A 1 450 ? -8.163  -51.053 -28.725 0.34 29.55  ? 713  PHE A CA  1 
ATOM   3246 C  C   . PHE A 1 450 ? -7.428  -52.232 -29.362 0.34 29.76  ? 713  PHE A C   1 
ATOM   3247 O  O   . PHE A 1 450 ? -6.249  -52.077 -29.734 0.34 31.17  ? 713  PHE A O   1 
ATOM   3248 C  CB  . PHE A 1 450 ? -8.645  -49.986 -29.706 0.34 30.19  ? 713  PHE A CB  1 
ATOM   3249 C  CG  . PHE A 1 450 ? -9.386  -48.882 -28.997 0.34 30.92  ? 713  PHE A CG  1 
ATOM   3250 C  CD1 . PHE A 1 450 ? -8.700  -47.817 -28.434 0.34 30.82  ? 713  PHE A CD1 1 
ATOM   3251 C  CD2 . PHE A 1 450 ? -10.757 -48.952 -28.817 0.34 30.68  ? 713  PHE A CD2 1 
ATOM   3252 C  CE1 . PHE A 1 450 ? -9.378  -46.823 -27.747 0.34 30.99  ? 713  PHE A CE1 1 
ATOM   3253 C  CE2 . PHE A 1 450 ? -11.431 -47.954 -28.133 0.34 31.05  ? 713  PHE A CE2 1 
ATOM   3254 C  CZ  . PHE A 1 450 ? -10.741 -46.895 -27.596 0.34 30.61  ? 713  PHE A CZ  1 
ATOM   3255 N  N   . HIS A 1 451 ? -8.106  -53.384 -29.421 1.00 29.91  ? 714  HIS A N   1 
ATOM   3256 C  CA  . HIS A 1 451 ? -7.589  -54.629 -30.045 1.00 31.22  ? 714  HIS A CA  1 
ATOM   3257 C  C   . HIS A 1 451 ? -8.294  -54.809 -31.382 1.00 30.48  ? 714  HIS A C   1 
ATOM   3258 O  O   . HIS A 1 451 ? -9.478  -54.415 -31.477 1.00 32.61  ? 714  HIS A O   1 
ATOM   3259 C  CB  . HIS A 1 451 ? -7.801  -55.844 -29.131 1.00 29.24  ? 714  HIS A CB  1 
ATOM   3260 C  CG  . HIS A 1 451 ? -7.111  -55.810 -27.804 1.00 28.12  ? 714  HIS A CG  1 
ATOM   3261 N  ND1 . HIS A 1 451 ? -6.027  -56.588 -27.527 1.00 29.57  ? 714  HIS A ND1 1 
ATOM   3262 C  CD2 . HIS A 1 451 ? -7.407  -55.172 -26.640 1.00 31.10  ? 714  HIS A CD2 1 
ATOM   3263 C  CE1 . HIS A 1 451 ? -5.697  -56.443 -26.237 1.00 30.89  ? 714  HIS A CE1 1 
ATOM   3264 N  NE2 . HIS A 1 451 ? -6.511  -55.550 -25.666 1.00 20.51  ? 714  HIS A NE2 1 
ATOM   3265 N  N   . GLU A 1 452 ? -7.569  -55.327 -32.368 1.00 35.03  ? 715  GLU A N   1 
ATOM   3266 C  CA  . GLU A 1 452 ? -8.104  -55.871 -33.644 1.00 38.59  ? 715  GLU A CA  1 
ATOM   3267 C  C   . GLU A 1 452 ? -8.382  -57.353 -33.406 1.00 40.25  ? 715  GLU A C   1 
ATOM   3268 O  O   . GLU A 1 452 ? -7.499  -58.089 -33.005 1.00 42.24  ? 715  GLU A O   1 
ATOM   3269 C  CB  . GLU A 1 452 ? -7.145  -55.650 -34.806 1.00 42.12  ? 715  GLU A CB  1 
ATOM   3270 C  CG  . GLU A 1 452 ? -7.867  -55.144 -36.034 1.00 48.11  ? 715  GLU A CG  1 
ATOM   3271 C  CD  . GLU A 1 452 ? -6.970  -54.830 -37.221 1.00 55.10  ? 715  GLU A CD  1 
ATOM   3272 O  OE1 . GLU A 1 452 ? -7.412  -54.024 -38.119 1.00 51.57  ? 715  GLU A OE1 1 
ATOM   3273 O  OE2 . GLU A 1 452 ? -5.840  -55.397 -37.251 1.00 62.29  ? 715  GLU A OE2 1 
ATOM   3274 N  N   . LEU A 1 453 ? -9.632  -57.761 -33.623 0.36 40.96  ? 716  LEU A N   1 
ATOM   3275 C  CA  . LEU A 1 453 ? -10.134 -59.121 -33.299 0.36 42.54  ? 716  LEU A CA  1 
ATOM   3276 C  C   . LEU A 1 453 ? -10.878 -59.673 -34.519 0.36 42.54  ? 716  LEU A C   1 
ATOM   3277 O  O   . LEU A 1 453 ? -11.880 -59.057 -34.935 0.36 40.96  ? 716  LEU A O   1 
ATOM   3278 C  CB  . LEU A 1 453 ? -11.030 -59.016 -32.063 0.36 43.74  ? 716  LEU A CB  1 
ATOM   3279 C  CG  . LEU A 1 453 ? -11.706 -60.305 -31.607 0.36 45.88  ? 716  LEU A CG  1 
ATOM   3280 C  CD1 . LEU A 1 453 ? -10.710 -61.450 -31.540 0.36 47.51  ? 716  LEU A CD1 1 
ATOM   3281 C  CD2 . LEU A 1 453 ? -12.386 -60.104 -30.260 0.36 47.12  ? 716  LEU A CD2 1 
ATOM   3282 N  N   . ILE A 1 454 ? -10.371 -60.769 -35.087 0.36 43.20  ? 717  ILE A N   1 
ATOM   3283 C  CA  . ILE A 1 454 ? -10.915 -61.401 -36.324 0.36 43.26  ? 717  ILE A CA  1 
ATOM   3284 C  C   . ILE A 1 454 ? -11.925 -62.475 -35.905 0.36 42.29  ? 717  ILE A C   1 
ATOM   3285 O  O   . ILE A 1 454 ? -11.555 -63.368 -35.118 0.36 40.22  ? 717  ILE A O   1 
ATOM   3286 C  CB  . ILE A 1 454 ? -9.776  -61.957 -37.203 0.36 45.40  ? 717  ILE A CB  1 
ATOM   3287 C  CG1 . ILE A 1 454 ? -8.729  -60.884 -37.516 0.36 45.43  ? 717  ILE A CG1 1 
ATOM   3288 C  CG2 . ILE A 1 454 ? -10.325 -62.579 -38.480 0.36 46.11  ? 717  ILE A CG2 1 
ATOM   3289 C  CD1 . ILE A 1 454 ? -7.387  -61.442 -37.919 0.36 46.36  ? 717  ILE A CD1 1 
ATOM   3290 N  N   . MET A 1 455 ? -13.161 -62.358 -36.394 1.00 41.98  ? 718  MET A N   1 
ATOM   3291 C  CA  . MET A 1 455 ? -14.240 -63.351 -36.145 1.00 46.17  ? 718  MET A CA  1 
ATOM   3292 C  C   . MET A 1 455 ? -13.954 -64.606 -36.965 1.00 45.41  ? 718  MET A C   1 
ATOM   3293 O  O   . MET A 1 455 ? -13.267 -64.528 -37.992 1.00 41.93  ? 718  MET A O   1 
ATOM   3294 C  CB  . MET A 1 455 ? -15.602 -62.800 -36.569 1.00 44.23  ? 718  MET A CB  1 
ATOM   3295 C  CG  . MET A 1 455 ? -15.995 -61.585 -35.782 1.00 47.90  ? 718  MET A CG  1 
ATOM   3296 S  SD  . MET A 1 455 ? -17.564 -60.884 -36.310 1.00 48.48  ? 718  MET A SD  1 
ATOM   3297 C  CE  . MET A 1 455 ? -18.658 -62.091 -35.571 1.00 45.03  ? 718  MET A CE  1 
ATOM   3298 N  N   A LYS A 1 456 ? -14.490 -65.743 -36.524 0.18 47.35  ? 719  LYS A N   1 
ATOM   3299 N  N   B LYS A 1 456 ? -14.500 -65.735 -36.511 0.18 47.56  ? 719  LYS A N   1 
ATOM   3300 C  CA  A LYS A 1 456 ? -14.297 -67.061 -37.189 0.18 49.70  ? 719  LYS A CA  1 
ATOM   3301 C  CA  B LYS A 1 456 ? -14.362 -67.067 -37.160 0.18 50.04  ? 719  LYS A CA  1 
ATOM   3302 C  C   A LYS A 1 456 ? -14.723 -66.967 -38.663 0.18 49.02  ? 719  LYS A C   1 
ATOM   3303 C  C   B LYS A 1 456 ? -14.707 -66.948 -38.653 0.18 49.15  ? 719  LYS A C   1 
ATOM   3304 O  O   A LYS A 1 456 ? -14.236 -67.793 -39.452 0.18 51.36  ? 719  LYS A O   1 
ATOM   3305 O  O   B LYS A 1 456 ? -14.144 -67.728 -39.440 0.18 51.20  ? 719  LYS A O   1 
ATOM   3306 C  CB  A LYS A 1 456 ? -15.027 -68.165 -36.415 0.18 51.11  ? 719  LYS A CB  1 
ATOM   3307 C  CB  B LYS A 1 456 ? -15.231 -68.097 -36.428 0.18 51.78  ? 719  LYS A CB  1 
ATOM   3308 C  CG  A LYS A 1 456 ? -14.164 -68.900 -35.397 0.18 52.93  ? 719  LYS A CG  1 
ATOM   3309 C  CG  B LYS A 1 456 ? -15.173 -69.508 -36.996 0.18 54.13  ? 719  LYS A CG  1 
ATOM   3310 C  CD  A LYS A 1 456 ? -14.920 -69.409 -34.189 0.18 54.81  ? 719  LYS A CD  1 
ATOM   3311 C  CD  B LYS A 1 456 ? -15.425 -70.605 -35.978 0.18 55.26  ? 719  LYS A CD  1 
ATOM   3312 C  CE  A LYS A 1 456 ? -15.280 -68.307 -33.216 0.18 55.48  ? 719  LYS A CE  1 
ATOM   3313 C  CE  B LYS A 1 456 ? -15.727 -71.944 -36.619 0.18 55.49  ? 719  LYS A CE  1 
ATOM   3314 N  NZ  A LYS A 1 456 ? -15.676 -68.842 -31.893 0.18 56.85  ? 719  LYS A NZ  1 
ATOM   3315 N  NZ  B LYS A 1 456 ? -15.029 -73.055 -35.928 0.18 55.81  ? 719  LYS A NZ  1 
ATOM   3316 N  N   . ASP A 1 457 ? -15.559 -65.986 -39.029 1.00 47.34  ? 720  ASP A N   1 
ATOM   3317 C  CA  . ASP A 1 457 ? -15.964 -65.750 -40.455 1.00 49.14  ? 720  ASP A CA  1 
ATOM   3318 C  C   . ASP A 1 457 ? -15.143 -64.659 -41.177 1.00 52.87  ? 720  ASP A C   1 
ATOM   3319 O  O   . ASP A 1 457 ? -15.612 -64.194 -42.242 1.00 48.88  ? 720  ASP A O   1 
ATOM   3320 C  CB  . ASP A 1 457 ? -17.442 -65.353 -40.535 1.00 53.65  ? 720  ASP A CB  1 
ATOM   3321 C  CG  . ASP A 1 457 ? -17.760 -64.068 -39.805 1.00 56.99  ? 720  ASP A CG  1 
ATOM   3322 O  OD1 . ASP A 1 457 ? -16.960 -63.112 -39.940 1.00 56.69  ? 720  ASP A OD1 1 
ATOM   3323 O  OD2 . ASP A 1 457 ? -18.793 -64.040 -39.099 1.00 61.51  ? 720  ASP A OD2 1 
ATOM   3324 N  N   . GLY A 1 458 ? -14.014 -64.202 -40.617 1.00 52.70  ? 721  GLY A N   1 
ATOM   3325 C  CA  . GLY A 1 458 ? -13.072 -63.266 -41.269 1.00 51.28  ? 721  GLY A CA  1 
ATOM   3326 C  C   . GLY A 1 458 ? -13.412 -61.794 -41.057 1.00 51.25  ? 721  GLY A C   1 
ATOM   3327 O  O   . GLY A 1 458 ? -12.550 -60.950 -41.329 1.00 55.73  ? 721  GLY A O   1 
ATOM   3328 N  N   . ARG A 1 459 ? -14.611 -61.465 -40.569 1.00 47.55  ? 722  ARG A N   1 
ATOM   3329 C  CA  . ARG A 1 459 ? -14.999 -60.051 -40.353 1.00 40.85  ? 722  ARG A CA  1 
ATOM   3330 C  C   . ARG A 1 459 ? -14.192 -59.473 -39.178 1.00 43.48  ? 722  ARG A C   1 
ATOM   3331 O  O   . ARG A 1 459 ? -13.792 -60.215 -38.243 1.00 39.36  ? 722  ARG A O   1 
ATOM   3332 C  CB  . ARG A 1 459 ? -16.515 -59.959 -40.178 1.00 43.49  ? 722  ARG A CB  1 
ATOM   3333 C  CG  . ARG A 1 459 ? -17.313 -60.320 -41.429 1.00 42.48  ? 722  ARG A CG  1 
ATOM   3334 C  CD  . ARG A 1 459 ? -18.802 -60.041 -41.284 1.00 42.38  ? 722  ARG A CD  1 
ATOM   3335 N  NE  . ARG A 1 459 ? -19.398 -60.880 -40.267 1.00 40.81  ? 722  ARG A NE  1 
ATOM   3336 C  CZ  . ARG A 1 459 ? -20.683 -60.896 -39.967 1.00 43.92  ? 722  ARG A CZ  1 
ATOM   3337 N  NH1 . ARG A 1 459 ? -21.526 -60.112 -40.611 1.00 46.71  ? 722  ARG A NH1 1 
ATOM   3338 N  NH2 . ARG A 1 459 ? -21.129 -61.709 -39.024 1.00 47.19  ? 722  ARG A NH2 1 
ATOM   3339 N  N   . VAL A 1 460 ? -13.947 -58.170 -39.207 1.00 42.62  ? 723  VAL A N   1 
ATOM   3340 C  CA  . VAL A 1 460 ? -12.970 -57.553 -38.273 1.00 39.20  ? 723  VAL A CA  1 
ATOM   3341 C  C   . VAL A 1 460 ? -13.700 -56.654 -37.288 1.00 34.60  ? 723  VAL A C   1 
ATOM   3342 O  O   . VAL A 1 460 ? -14.345 -55.674 -37.717 1.00 40.85  ? 723  VAL A O   1 
ATOM   3343 C  CB  . VAL A 1 460 ? -11.846 -56.812 -39.009 1.00 44.08  ? 723  VAL A CB  1 
ATOM   3344 C  CG1 . VAL A 1 460 ? -10.786 -56.339 -38.028 1.00 53.19  ? 723  VAL A CG1 1 
ATOM   3345 C  CG2 . VAL A 1 460 ? -11.202 -57.695 -40.059 1.00 47.46  ? 723  VAL A CG2 1 
ATOM   3346 N  N   . LEU A 1 461 ? -13.577 -56.993 -36.002 1.00 31.35  ? 724  LEU A N   1 
ATOM   3347 C  CA  . LEU A 1 461 ? -14.025 -56.171 -34.860 1.00 29.36  ? 724  LEU A CA  1 
ATOM   3348 C  C   . LEU A 1 461 ? -12.823 -55.363 -34.338 1.00 35.53  ? 724  LEU A C   1 
ATOM   3349 O  O   . LEU A 1 461 ? -11.716 -55.946 -34.159 1.00 36.07  ? 724  LEU A O   1 
ATOM   3350 C  CB  . LEU A 1 461 ? -14.550 -57.125 -33.793 1.00 33.94  ? 724  LEU A CB  1 
ATOM   3351 C  CG  . LEU A 1 461 ? -15.747 -57.988 -34.213 1.00 31.35  ? 724  LEU A CG  1 
ATOM   3352 C  CD1 . LEU A 1 461 ? -16.093 -58.940 -33.102 1.00 33.20  ? 724  LEU A CD1 1 
ATOM   3353 C  CD2 . LEU A 1 461 ? -16.936 -57.129 -34.560 1.00 31.40  ? 724  LEU A CD2 1 
ATOM   3354 N  N   . VAL A 1 462 ? -13.001 -54.066 -34.112 1.00 31.80  ? 725  VAL A N   1 
ATOM   3355 C  CA  . VAL A 1 462 ? -12.052 -53.251 -33.310 1.00 28.97  ? 725  VAL A CA  1 
ATOM   3356 C  C   . VAL A 1 462 ? -12.743 -52.949 -31.985 1.00 28.87  ? 725  VAL A C   1 
ATOM   3357 O  O   . VAL A 1 462 ? -13.759 -52.244 -31.999 1.00 28.81  ? 725  VAL A O   1 
ATOM   3358 C  CB  . VAL A 1 462 ? -11.594 -51.983 -34.050 1.00 29.22  ? 725  VAL A CB  1 
ATOM   3359 C  CG1 . VAL A 1 462 ? -10.694 -51.128 -33.152 1.00 32.92  ? 725  VAL A CG1 1 
ATOM   3360 C  CG2 . VAL A 1 462 ? -10.863 -52.325 -35.329 1.00 27.59  ? 725  VAL A CG2 1 
ATOM   3361 N  N   . VAL A 1 463 ? -12.221 -53.498 -30.893 1.00 28.56  ? 726  VAL A N   1 
ATOM   3362 C  CA  . VAL A 1 463 ? -12.920 -53.595 -29.579 1.00 27.11  ? 726  VAL A CA  1 
ATOM   3363 C  C   . VAL A 1 463 ? -12.175 -52.773 -28.541 1.00 25.93  ? 726  VAL A C   1 
ATOM   3364 O  O   . VAL A 1 463 ? -10.945 -52.713 -28.543 1.00 28.82  ? 726  VAL A O   1 
ATOM   3365 C  CB  . VAL A 1 463 ? -13.035 -55.059 -29.140 1.00 26.94  ? 726  VAL A CB  1 
ATOM   3366 C  CG1 . VAL A 1 463 ? -13.899 -55.831 -30.118 1.00 29.64  ? 726  VAL A CG1 1 
ATOM   3367 C  CG2 . VAL A 1 463 ? -11.662 -55.717 -28.978 1.00 28.46  ? 726  VAL A CG2 1 
ATOM   3368 N  N   . PRO A 1 464 ? -12.900 -52.120 -27.624 1.00 27.38  ? 727  PRO A N   1 
ATOM   3369 C  CA  . PRO A 1 464 ? -12.274 -51.365 -26.544 1.00 25.61  ? 727  PRO A CA  1 
ATOM   3370 C  C   . PRO A 1 464 ? -11.885 -52.286 -25.392 1.00 28.21  ? 727  PRO A C   1 
ATOM   3371 O  O   . PRO A 1 464 ? -12.485 -53.331 -25.238 1.00 24.55  ? 727  PRO A O   1 
ATOM   3372 C  CB  . PRO A 1 464 ? -13.411 -50.454 -26.103 1.00 28.07  ? 727  PRO A CB  1 
ATOM   3373 C  CG  . PRO A 1 464 ? -14.656 -51.342 -26.261 1.00 28.56  ? 727  PRO A CG  1 
ATOM   3374 C  CD  . PRO A 1 464 ? -14.380 -52.101 -27.552 1.00 28.44  ? 727  PRO A CD  1 
ATOM   3375 N  N   . CYS A 1 465 ? -10.886 -51.873 -24.608 1.00 28.71  ? 728  CYS A N   1 
ATOM   3376 C  CA  . CYS A 1 465 ? -10.267 -52.715 -23.560 1.00 27.05  ? 728  CYS A CA  1 
ATOM   3377 C  C   . CYS A 1 465 ? -9.583  -51.829 -22.519 1.00 30.28  ? 728  CYS A C   1 
ATOM   3378 O  O   . CYS A 1 465 ? -9.139  -50.743 -22.869 1.00 29.12  ? 728  CYS A O   1 
ATOM   3379 C  CB  . CYS A 1 465 ? -9.288  -53.708 -24.184 1.00 26.19  ? 728  CYS A CB  1 
ATOM   3380 S  SG  . CYS A 1 465 ? -8.807  -55.033 -23.045 1.00 26.83  ? 728  CYS A SG  1 
ATOM   3381 N  N   . ARG A 1 466 ? -9.571  -52.260 -21.266 1.00 30.29  ? 729  ARG A N   1 
ATOM   3382 C  CA  . ARG A 1 466 ? -8.668  -51.710 -20.256 1.00 29.52  ? 729  ARG A CA  1 
ATOM   3383 C  C   . ARG A 1 466 ? -8.402  -52.778 -19.202 1.00 29.55  ? 729  ARG A C   1 
ATOM   3384 O  O   . ARG A 1 466 ? -8.986  -53.863 -19.268 1.00 29.45  ? 729  ARG A O   1 
ATOM   3385 C  CB  . ARG A 1 466 ? -9.232  -50.429 -19.665 1.00 32.91  ? 729  ARG A CB  1 
ATOM   3386 C  CG  . ARG A 1 466 ? -10.558 -50.610 -18.965 1.00 36.50  ? 729  ARG A CG  1 
ATOM   3387 C  CD  . ARG A 1 466 ? -11.260 -49.284 -18.709 1.00 34.18  ? 729  ARG A CD  1 
ATOM   3388 N  NE  . ARG A 1 466 ? -10.678 -48.565 -17.605 1.00 33.03  ? 729  ARG A NE  1 
ATOM   3389 C  CZ  . ARG A 1 466 ? -11.181 -47.450 -17.091 1.00 38.32  ? 729  ARG A CZ  1 
ATOM   3390 N  NH1 . ARG A 1 466 ? -12.313 -46.924 -17.550 1.00 37.84  ? 729  ARG A NH1 1 
ATOM   3391 N  NH2 . ARG A 1 466 ? -10.540 -46.870 -16.106 1.00 38.36  ? 729  ARG A NH2 1 
ATOM   3392 N  N   . ASN A 1 467 ? -7.500  -52.484 -18.278 1.00 30.31  ? 730  ASN A N   1 
ATOM   3393 C  CA  . ASN A 1 467 ? -7.119  -53.462 -17.236 1.00 31.96  ? 730  ASN A CA  1 
ATOM   3394 C  C   . ASN A 1 467 ? -8.412  -53.946 -16.561 1.00 27.30  ? 730  ASN A C   1 
ATOM   3395 O  O   . ASN A 1 467 ? -9.136  -53.138 -16.058 1.00 27.48  ? 730  ASN A O   1 
ATOM   3396 C  CB  . ASN A 1 467 ? -6.065  -52.928 -16.273 1.00 30.24  ? 730  ASN A CB  1 
ATOM   3397 C  CG  . ASN A 1 467 ? -5.778  -53.952 -15.200 1.00 35.07  ? 730  ASN A CG  1 
ATOM   3398 O  OD1 . ASN A 1 467 ? -6.486  -54.009 -14.213 1.00 32.43  ? 730  ASN A OD1 1 
ATOM   3399 N  ND2 . ASN A 1 467 ? -4.791  -54.811 -15.425 1.00 42.79  ? 730  ASN A ND2 1 
ATOM   3400 N  N   . GLN A 1 468 ? -8.608  -55.252 -16.484 1.00 27.23  ? 731  GLN A N   1 
ATOM   3401 C  CA  . GLN A 1 468 ? -9.894  -55.848 -16.063 1.00 27.28  ? 731  GLN A CA  1 
ATOM   3402 C  C   . GLN A 1 468 ? -10.104 -55.541 -14.588 1.00 28.78  ? 731  GLN A C   1 
ATOM   3403 O  O   . GLN A 1 468 ? -11.275 -55.379 -14.188 1.00 26.44  ? 731  GLN A O   1 
ATOM   3404 C  CB  . GLN A 1 468 ? -9.919  -57.333 -16.392 1.00 28.52  ? 731  GLN A CB  1 
ATOM   3405 C  CG  . GLN A 1 468 ? -11.273 -57.979 -16.170 1.00 26.90  ? 731  GLN A CG  1 
ATOM   3406 C  CD  . GLN A 1 468 ? -11.190 -59.463 -16.402 1.00 27.75  ? 731  GLN A CD  1 
ATOM   3407 O  OE1 . GLN A 1 468 ? -11.513 -59.961 -17.477 1.00 29.04  ? 731  GLN A OE1 1 
ATOM   3408 N  NE2 . GLN A 1 468 ? -10.778 -60.190 -15.384 1.00 27.61  ? 731  GLN A NE2 1 
ATOM   3409 N  N   . ASP A 1 469 ? -9.031  -55.344 -13.826 1.00 27.98  ? 732  ASP A N   1 
ATOM   3410 C  CA  . ASP A 1 469 ? -9.185  -54.921 -12.406 1.00 30.16  ? 732  ASP A CA  1 
ATOM   3411 C  C   . ASP A 1 469 ? -9.944  -53.589 -12.292 1.00 30.32  ? 732  ASP A C   1 
ATOM   3412 O  O   . ASP A 1 469 ? -10.707 -53.426 -11.335 1.00 32.58  ? 732  ASP A O   1 
ATOM   3413 C  CB  . ASP A 1 469 ? -7.861  -54.806 -11.660 1.00 30.00  ? 732  ASP A CB  1 
ATOM   3414 C  CG  . ASP A 1 469 ? -7.156  -56.146 -11.470 1.00 35.88  ? 732  ASP A CG  1 
ATOM   3415 O  OD1 . ASP A 1 469 ? -7.816  -57.223 -11.617 1.00 34.54  ? 732  ASP A OD1 1 
ATOM   3416 O  OD2 . ASP A 1 469 ? -5.947  -56.100 -11.184 1.00 40.48  ? 732  ASP A OD2 1 
ATOM   3417 N  N   . GLU A 1 470 ? -9.717  -52.655 -13.219 0.48 29.66  ? 733  GLU A N   1 
ATOM   3418 C  CA  . GLU A 1 470 ? -10.399 -51.334 -13.227 0.48 29.30  ? 733  GLU A CA  1 
ATOM   3419 C  C   . GLU A 1 470 ? -11.890 -51.549 -13.532 0.48 28.82  ? 733  GLU A C   1 
ATOM   3420 O  O   . GLU A 1 470 ? -12.717 -50.913 -12.863 0.48 29.36  ? 733  GLU A O   1 
ATOM   3421 C  CB  . GLU A 1 470 ? -9.742  -50.378 -14.226 0.48 29.93  ? 733  GLU A CB  1 
ATOM   3422 C  CG  . GLU A 1 470 ? -8.342  -49.936 -13.816 0.48 31.59  ? 733  GLU A CG  1 
ATOM   3423 C  CD  . GLU A 1 470 ? -7.548  -49.193 -14.880 0.48 32.12  ? 733  GLU A CD  1 
ATOM   3424 O  OE1 . GLU A 1 470 ? -6.314  -49.090 -14.728 0.48 34.84  ? 733  GLU A OE1 1 
ATOM   3425 O  OE2 . GLU A 1 470 ? -8.157  -48.730 -15.864 0.48 32.59  ? 733  GLU A OE2 1 
ATOM   3426 N  N   . LEU A 1 471 ? -12.220 -52.428 -14.483 1.00 27.37  ? 734  LEU A N   1 
ATOM   3427 C  CA  . LEU A 1 471 ? -13.626 -52.714 -14.859 1.00 27.44  ? 734  LEU A CA  1 
ATOM   3428 C  C   . LEU A 1 471 ? -14.402 -53.370 -13.712 1.00 27.30  ? 734  LEU A C   1 
ATOM   3429 O  O   . LEU A 1 471 ? -15.513 -52.886 -13.329 1.00 28.25  ? 734  LEU A O   1 
ATOM   3430 C  CB  . LEU A 1 471 ? -13.577 -53.575 -16.116 1.00 26.51  ? 734  LEU A CB  1 
ATOM   3431 C  CG  . LEU A 1 471 ? -13.072 -52.813 -17.341 1.00 27.42  ? 734  LEU A CG  1 
ATOM   3432 C  CD1 . LEU A 1 471 ? -13.108 -53.683 -18.577 1.00 28.21  ? 734  LEU A CD1 1 
ATOM   3433 C  CD2 . LEU A 1 471 ? -13.878 -51.545 -17.568 1.00 28.45  ? 734  LEU A CD2 1 
ATOM   3434 N  N   . ILE A 1 472 ? -13.833 -54.392 -13.111 1.00 28.45  ? 735  ILE A N   1 
ATOM   3435 C  CA  . ILE A 1 472 ? -14.492 -55.085 -11.975 1.00 28.27  ? 735  ILE A CA  1 
ATOM   3436 C  C   . ILE A 1 472 ? -14.578 -54.171 -10.746 1.00 28.99  ? 735  ILE A C   1 
ATOM   3437 O  O   . ILE A 1 472 ? -15.663 -54.146 -10.118 1.00 26.70  ? 735  ILE A O   1 
ATOM   3438 C  CB  . ILE A 1 472 ? -13.781 -56.405 -11.718 1.00 26.98  ? 735  ILE A CB  1 
ATOM   3439 C  CG1 . ILE A 1 472 ? -13.958 -57.274 -12.962 1.00 27.64  ? 735  ILE A CG1 1 
ATOM   3440 C  CG2 . ILE A 1 472 ? -14.317 -57.045 -10.435 1.00 27.86  ? 735  ILE A CG2 1 
ATOM   3441 C  CD1 . ILE A 1 472 ? -13.323 -58.625 -12.874 1.00 31.26  ? 735  ILE A CD1 1 
ATOM   3442 N  N   . GLY A 1 473 ? -13.519 -53.427 -10.431 1.00 25.50  ? 736  GLY A N   1 
ATOM   3443 C  CA  . GLY A 1 473 ? -13.533 -52.481 -9.295  1.00 29.53  ? 736  GLY A CA  1 
ATOM   3444 C  C   . GLY A 1 473 ? -14.620 -51.386 -9.396  1.00 31.25  ? 736  GLY A C   1 
ATOM   3445 O  O   . GLY A 1 473 ? -15.237 -51.054 -8.362  1.00 31.41  ? 736  GLY A O   1 
ATOM   3446 N  N   . ARG A 1 474 ? -14.847 -50.858 -10.603 0.48 30.50  ? 737  ARG A N   1 
ATOM   3447 C  CA  . ARG A 1 474 ? -15.852 -49.794 -10.892 0.48 32.50  ? 737  ARG A CA  1 
ATOM   3448 C  C   . ARG A 1 474 ? -17.272 -50.363 -10.744 0.48 31.44  ? 737  ARG A C   1 
ATOM   3449 O  O   . ARG A 1 474 ? -18.137 -49.664 -10.171 0.48 32.62  ? 737  ARG A O   1 
ATOM   3450 C  CB  . ARG A 1 474 ? -15.658 -49.238 -12.309 0.48 34.46  ? 737  ARG A CB  1 
ATOM   3451 C  CG  . ARG A 1 474 ? -14.302 -48.590 -12.544 0.48 39.00  ? 737  ARG A CG  1 
ATOM   3452 C  CD  . ARG A 1 474 ? -14.007 -48.256 -14.003 0.48 40.23  ? 737  ARG A CD  1 
ATOM   3453 N  NE  . ARG A 1 474 ? -14.636 -46.996 -14.385 0.48 42.23  ? 737  ARG A NE  1 
ATOM   3454 C  CZ  . ARG A 1 474 ? -14.274 -45.796 -13.931 0.48 40.86  ? 737  ARG A CZ  1 
ATOM   3455 N  NH1 . ARG A 1 474 ? -14.919 -44.717 -14.340 0.48 40.80  ? 737  ARG A NH1 1 
ATOM   3456 N  NH2 . ARG A 1 474 ? -13.273 -45.671 -13.076 0.48 40.53  ? 737  ARG A NH2 1 
ATOM   3457 N  N   . ALA A 1 475 ? -17.503 -51.576 -11.255 1.00 29.44  ? 738  ALA A N   1 
ATOM   3458 C  CA  . ALA A 1 475 ? -18.831 -52.247 -11.218 1.00 29.10  ? 738  ALA A CA  1 
ATOM   3459 C  C   . ALA A 1 475 ? -19.203 -52.588 -9.770  1.00 30.54  ? 738  ALA A C   1 
ATOM   3460 O  O   . ALA A 1 475 ? -20.420 -52.656 -9.460  1.00 29.57  ? 738  ALA A O   1 
ATOM   3461 C  CB  . ALA A 1 475 ? -18.849 -53.482 -12.081 1.00 26.62  ? 738  ALA A CB  1 
ATOM   3462 N  N   . ARG A 1 476 ? -18.214 -52.723 -8.881  1.00 30.42  ? 739  ARG A N   1 
ATOM   3463 C  CA  . ARG A 1 476 ? -18.483 -53.034 -7.447  1.00 33.33  ? 739  ARG A CA  1 
ATOM   3464 C  C   . ARG A 1 476 ? -18.839 -51.800 -6.604  1.00 33.67  ? 739  ARG A C   1 
ATOM   3465 O  O   . ARG A 1 476 ? -19.114 -51.945 -5.408  1.00 33.05  ? 739  ARG A O   1 
ATOM   3466 C  CB  . ARG A 1 476 ? -17.318 -53.834 -6.855  1.00 30.16  ? 739  ARG A CB  1 
ATOM   3467 C  CG  . ARG A 1 476 ? -17.354 -55.290 -7.308  1.00 29.92  ? 739  ARG A CG  1 
ATOM   3468 C  CD  . ARG A 1 476 ? -16.000 -55.988 -7.235  1.00 30.78  ? 739  ARG A CD  1 
ATOM   3469 N  NE  . ARG A 1 476 ? -15.562 -56.240 -5.871  1.00 26.66  ? 739  ARG A NE  1 
ATOM   3470 C  CZ  . ARG A 1 476 ? -15.244 -57.417 -5.352  1.00 26.17  ? 739  ARG A CZ  1 
ATOM   3471 N  NH1 . ARG A 1 476 ? -15.333 -58.532 -6.041  1.00 30.24  ? 739  ARG A NH1 1 
ATOM   3472 N  NH2 . ARG A 1 476 ? -14.818 -57.473 -4.108  1.00 29.41  ? 739  ARG A NH2 1 
ATOM   3473 N  N   . ILE A 1 477 ? -18.817 -50.620 -7.222  0.48 37.10  ? 740  ILE A N   1 
ATOM   3474 C  CA  . ILE A 1 477 ? -18.997 -49.314 -6.526  0.48 42.54  ? 740  ILE A CA  1 
ATOM   3475 C  C   . ILE A 1 477 ? -20.316 -48.684 -6.979  0.48 44.58  ? 740  ILE A C   1 
ATOM   3476 O  O   . ILE A 1 477 ? -20.613 -48.726 -8.187  0.48 43.26  ? 740  ILE A O   1 
ATOM   3477 C  CB  . ILE A 1 477 ? -17.790 -48.394 -6.786  0.48 44.01  ? 740  ILE A CB  1 
ATOM   3478 C  CG1 . ILE A 1 477 ? -16.522 -48.938 -6.119  0.48 44.69  ? 740  ILE A CG1 1 
ATOM   3479 C  CG2 . ILE A 1 477 ? -18.094 -46.971 -6.340  0.48 46.21  ? 740  ILE A CG2 1 
ATOM   3480 C  CD1 . ILE A 1 477 ? -15.243 -48.292 -6.610  0.48 45.57  ? 740  ILE A CD1 1 
ATOM   3481 N  N   . SER A 1 478 ? -21.073 -48.138 -6.025  0.48 50.65  ? 741  SER A N   1 
ATOM   3482 C  CA  . SER A 1 478 ? -22.288 -47.316 -6.265  0.48 56.08  ? 741  SER A CA  1 
ATOM   3483 C  C   . SER A 1 478 ? -22.018 -45.875 -5.817  0.48 60.73  ? 741  SER A C   1 
ATOM   3484 O  O   . SER A 1 478 ? -21.328 -45.692 -4.785  0.48 60.99  ? 741  SER A O   1 
ATOM   3485 C  CB  . SER A 1 478 ? -23.499 -47.910 -5.583  0.48 56.32  ? 741  SER A CB  1 
ATOM   3486 O  OG  . SER A 1 478 ? -23.315 -48.008 -4.179  0.48 56.22  ? 741  SER A OG  1 
ATOM   3487 N  N   . GLN A 1 479 ? -22.508 -44.900 -6.593  0.48 65.69  ? 742  GLN A N   1 
ATOM   3488 C  CA  . GLN A 1 479 ? -22.414 -43.444 -6.296  0.48 68.28  ? 742  GLN A CA  1 
ATOM   3489 C  C   . GLN A 1 479 ? -23.683 -43.006 -5.555  0.48 72.04  ? 742  GLN A C   1 
ATOM   3490 O  O   . GLN A 1 479 ? -24.621 -42.511 -6.217  0.48 72.45  ? 742  GLN A O   1 
ATOM   3491 C  CB  . GLN A 1 479 ? -22.203 -42.636 -7.580  0.48 69.44  ? 742  GLN A CB  1 
ATOM   3492 C  CG  . GLN A 1 479 ? -20.796 -42.767 -8.149  0.48 70.18  ? 742  GLN A CG  1 
ATOM   3493 C  CD  . GLN A 1 479 ? -20.590 -42.023 -9.447  0.48 69.24  ? 742  GLN A CD  1 
ATOM   3494 O  OE1 . GLN A 1 479 ? -19.741 -42.385 -10.259 0.48 70.18  ? 742  GLN A OE1 1 
ATOM   3495 N  NE2 . GLN A 1 479 ? -21.358 -40.966 -9.649  0.48 69.20  ? 742  GLN A NE2 1 
ATOM   3496 N  N   . GLY A 1 480 ? -23.697 -43.195 -4.231  0.48 72.71  ? 743  GLY A N   1 
ATOM   3497 C  CA  . GLY A 1 480 ? -24.812 -42.823 -3.340  0.48 71.81  ? 743  GLY A CA  1 
ATOM   3498 C  C   . GLY A 1 480 ? -25.225 -43.975 -2.442  0.48 69.25  ? 743  GLY A C   1 
ATOM   3499 O  O   . GLY A 1 480 ? -24.698 -45.092 -2.616  0.48 70.27  ? 743  GLY A O   1 
ATOM   3500 N  N   . ALA A 1 481 ? -26.153 -43.705 -1.523  0.48 67.31  ? 744  ALA A N   1 
ATOM   3501 C  CA  . ALA A 1 481 ? -26.688 -44.660 -0.528  0.48 63.11  ? 744  ALA A CA  1 
ATOM   3502 C  C   . ALA A 1 481 ? -28.216 -44.539 -0.477  0.48 62.26  ? 744  ALA A C   1 
ATOM   3503 O  O   . ALA A 1 481 ? -28.780 -43.722 -1.244  0.48 62.47  ? 744  ALA A O   1 
ATOM   3504 C  CB  . ALA A 1 481 ? -26.060 -44.383 0.813   0.48 62.86  ? 744  ALA A CB  1 
ATOM   3505 N  N   . GLY A 1 482 ? -28.858 -45.334 0.385   0.48 55.80  ? 745  GLY A N   1 
ATOM   3506 C  CA  . GLY A 1 482 ? -30.318 -45.317 0.592   0.48 53.22  ? 745  GLY A CA  1 
ATOM   3507 C  C   . GLY A 1 482 ? -31.065 -46.086 -0.485  0.48 48.87  ? 745  GLY A C   1 
ATOM   3508 O  O   . GLY A 1 482 ? -32.306 -46.047 -0.458  0.48 47.29  ? 745  GLY A O   1 
ATOM   3509 N  N   . TRP A 1 483 ? -30.348 -46.767 -1.389  0.48 44.55  ? 746  TRP A N   1 
ATOM   3510 C  CA  . TRP A 1 483 ? -30.933 -47.506 -2.542  0.48 42.72  ? 746  TRP A CA  1 
ATOM   3511 C  C   . TRP A 1 483 ? -31.515 -48.839 -2.050  0.48 39.08  ? 746  TRP A C   1 
ATOM   3512 O  O   . TRP A 1 483 ? -31.007 -49.376 -1.046  0.48 38.81  ? 746  TRP A O   1 
ATOM   3513 C  CB  . TRP A 1 483 ? -29.890 -47.708 -3.651  0.48 42.95  ? 746  TRP A CB  1 
ATOM   3514 C  CG  . TRP A 1 483 ? -29.207 -46.452 -4.106  0.48 46.59  ? 746  TRP A CG  1 
ATOM   3515 C  CD1 . TRP A 1 483 ? -27.924 -46.074 -3.824  0.48 50.50  ? 746  TRP A CD1 1 
ATOM   3516 C  CD2 . TRP A 1 483 ? -29.757 -45.400 -4.923  0.48 46.62  ? 746  TRP A CD2 1 
ATOM   3517 N  NE1 . TRP A 1 483 ? -27.638 -44.871 -4.413  0.48 51.17  ? 746  TRP A NE1 1 
ATOM   3518 C  CE2 . TRP A 1 483 ? -28.745 -44.428 -5.087  0.48 48.52  ? 746  TRP A CE2 1 
ATOM   3519 C  CE3 . TRP A 1 483 ? -30.998 -45.179 -5.528  0.48 47.01  ? 746  TRP A CE3 1 
ATOM   3520 C  CZ2 . TRP A 1 483 ? -28.936 -43.265 -5.831  0.48 47.38  ? 746  TRP A CZ2 1 
ATOM   3521 C  CZ3 . TRP A 1 483 ? -31.188 -44.028 -6.263  0.48 49.06  ? 746  TRP A CZ3 1 
ATOM   3522 C  CH2 . TRP A 1 483 ? -30.168 -43.088 -6.416  0.48 48.51  ? 746  TRP A CH2 1 
ATOM   3523 N  N   . SER A 1 484 ? -32.548 -49.347 -2.725  0.48 36.12  ? 747  SER A N   1 
ATOM   3524 C  CA  . SER A 1 484 ? -33.194 -50.652 -2.425  0.48 34.92  ? 747  SER A CA  1 
ATOM   3525 C  C   . SER A 1 484 ? -32.316 -51.789 -2.966  0.48 33.14  ? 747  SER A C   1 
ATOM   3526 O  O   . SER A 1 484 ? -31.381 -51.490 -3.730  0.48 32.88  ? 747  SER A O   1 
ATOM   3527 C  CB  . SER A 1 484 ? -34.600 -50.719 -2.987  0.48 33.00  ? 747  SER A CB  1 
ATOM   3528 O  OG  . SER A 1 484 ? -34.597 -51.146 -4.342  0.48 31.12  ? 747  SER A OG  1 
ATOM   3529 N  N   . LEU A 1 485 ? -32.619 -53.038 -2.595  1.00 32.01  ? 748  LEU A N   1 
ATOM   3530 C  CA  . LEU A 1 485 ? -31.977 -54.245 -3.201  1.00 34.76  ? 748  LEU A CA  1 
ATOM   3531 C  C   . LEU A 1 485 ? -32.282 -54.300 -4.700  1.00 34.58  ? 748  LEU A C   1 
ATOM   3532 O  O   . LEU A 1 485 ? -31.383 -54.603 -5.493  1.00 34.96  ? 748  LEU A O   1 
ATOM   3533 C  CB  . LEU A 1 485 ? -32.507 -55.507 -2.524  1.00 35.51  ? 748  LEU A CB  1 
ATOM   3534 C  CG  . LEU A 1 485 ? -31.911 -56.814 -3.030  1.00 36.89  ? 748  LEU A CG  1 
ATOM   3535 C  CD1 . LEU A 1 485 ? -30.409 -56.674 -3.204  1.00 38.75  ? 748  LEU A CD1 1 
ATOM   3536 C  CD2 . LEU A 1 485 ? -32.237 -57.944 -2.081  1.00 33.87  ? 748  LEU A CD2 1 
ATOM   3537 N  N   . ARG A 1 486 ? -33.505 -53.951 -5.078  1.00 33.30  ? 749  ARG A N   1 
ATOM   3538 C  CA  . ARG A 1 486 ? -33.947 -53.906 -6.491  1.00 33.37  ? 749  ARG A CA  1 
ATOM   3539 C  C   . ARG A 1 486 ? -33.114 -52.911 -7.324  1.00 31.58  ? 749  ARG A C   1 
ATOM   3540 O  O   . ARG A 1 486 ? -32.716 -53.251 -8.454  1.00 32.16  ? 749  ARG A O   1 
ATOM   3541 C  CB  . ARG A 1 486 ? -35.436 -53.555 -6.559  1.00 34.30  ? 749  ARG A CB  1 
ATOM   3542 C  CG  . ARG A 1 486 ? -35.929 -53.387 -7.989  1.00 35.62  ? 749  ARG A CG  1 
ATOM   3543 C  CD  . ARG A 1 486 ? -37.441 -53.492 -8.047  1.00 35.86  ? 749  ARG A CD  1 
ATOM   3544 N  NE  . ARG A 1 486 ? -37.962 -53.397 -9.411  1.00 37.72  ? 749  ARG A NE  1 
ATOM   3545 C  CZ  . ARG A 1 486 ? -39.098 -53.961 -9.804  1.00 36.61  ? 749  ARG A CZ  1 
ATOM   3546 N  NH1 . ARG A 1 486 ? -39.795 -54.687 -8.949  1.00 35.38  ? 749  ARG A NH1 1 
ATOM   3547 N  NH2 . ARG A 1 486 ? -39.501 -53.860 -11.056 1.00 37.58  ? 749  ARG A NH2 1 
ATOM   3548 N  N   . GLU A 1 487 ? -32.883 -51.709 -6.790  0.48 30.25  ? 750  GLU A N   1 
ATOM   3549 C  CA  . GLU A 1 487 ? -32.135 -50.619 -7.479  0.48 31.08  ? 750  GLU A CA  1 
ATOM   3550 C  C   . GLU A 1 487 ? -30.649 -51.016 -7.586  0.48 32.17  ? 750  GLU A C   1 
ATOM   3551 O  O   . GLU A 1 487 ? -30.039 -50.774 -8.656  0.48 30.24  ? 750  GLU A O   1 
ATOM   3552 C  CB  . GLU A 1 487 ? -32.323 -49.288 -6.742  0.48 31.44  ? 750  GLU A CB  1 
ATOM   3553 C  CG  . GLU A 1 487 ? -33.768 -48.809 -6.698  0.48 31.44  ? 750  GLU A CG  1 
ATOM   3554 C  CD  . GLU A 1 487 ? -34.043 -47.594 -5.826  0.48 31.84  ? 750  GLU A CD  1 
ATOM   3555 O  OE1 . GLU A 1 487 ? -33.587 -47.559 -4.660  0.48 29.90  ? 750  GLU A OE1 1 
ATOM   3556 O  OE2 . GLU A 1 487 ? -34.722 -46.678 -6.321  0.48 35.36  ? 750  GLU A OE2 1 
ATOM   3557 N  N   . THR A 1 488 ? -30.092 -51.617 -6.528  1.00 33.18  ? 751  THR A N   1 
ATOM   3558 C  CA  . THR A 1 488 ? -28.694 -52.149 -6.522  1.00 30.52  ? 751  THR A CA  1 
ATOM   3559 C  C   . THR A 1 488 ? -28.549 -53.236 -7.603  1.00 33.70  ? 751  THR A C   1 
ATOM   3560 O  O   . THR A 1 488 ? -27.542 -53.202 -8.378  1.00 33.77  ? 751  THR A O   1 
ATOM   3561 C  CB  . THR A 1 488 ? -28.356 -52.710 -5.150  1.00 30.01  ? 751  THR A CB  1 
ATOM   3562 O  OG1 . THR A 1 488 ? -28.573 -51.639 -4.217  1.00 32.41  ? 751  THR A OG1 1 
ATOM   3563 C  CG2 . THR A 1 488 ? -26.942 -53.257 -5.111  1.00 29.99  ? 751  THR A CG2 1 
ATOM   3564 N  N   . ALA A 1 489 ? -29.532 -54.139 -7.698  1.00 30.28  ? 752  ALA A N   1 
ATOM   3565 C  CA  . ALA A 1 489 ? -29.577 -55.222 -8.703  1.00 30.18  ? 752  ALA A CA  1 
ATOM   3566 C  C   . ALA A 1 489 ? -29.638 -54.640 -10.126 1.00 32.97  ? 752  ALA A C   1 
ATOM   3567 O  O   . ALA A 1 489 ? -28.909 -55.154 -10.989 1.00 30.85  ? 752  ALA A O   1 
ATOM   3568 C  CB  . ALA A 1 489 ? -30.749 -56.117 -8.414  1.00 31.71  ? 752  ALA A CB  1 
ATOM   3569 N  N   . CYS A 1 490 ? -30.457 -53.601 -10.369 1.00 30.67  ? 753  CYS A N   1 
ATOM   3570 C  CA  . CYS A 1 490 ? -30.619 -52.977 -11.715 1.00 30.21  ? 753  CYS A CA  1 
ATOM   3571 C  C   . CYS A 1 490 ? -29.323 -52.246 -12.126 1.00 27.15  ? 753  CYS A C   1 
ATOM   3572 O  O   . CYS A 1 490 ? -28.991 -52.204 -13.313 1.00 24.90  ? 753  CYS A O   1 
ATOM   3573 C  CB  . CYS A 1 490 ? -31.827 -52.041 -11.743 1.00 31.18  ? 753  CYS A CB  1 
ATOM   3574 S  SG  . CYS A 1 490 ? -33.399 -52.952 -11.587 1.00 33.78  ? 753  CYS A SG  1 
ATOM   3575 N  N   . LEU A 1 491 ? -28.617 -51.647 -11.188 1.00 27.19  ? 754  LEU A N   1 
ATOM   3576 C  CA  . LEU A 1 491 ? -27.271 -51.068 -11.460 1.00 28.61  ? 754  LEU A CA  1 
ATOM   3577 C  C   . LEU A 1 491 ? -26.253 -52.174 -11.797 1.00 29.92  ? 754  LEU A C   1 
ATOM   3578 O  O   . LEU A 1 491 ? -25.511 -52.032 -12.778 1.00 30.95  ? 754  LEU A O   1 
ATOM   3579 C  CB  . LEU A 1 491 ? -26.836 -50.256 -10.245 1.00 30.94  ? 754  LEU A CB  1 
ATOM   3580 C  CG  . LEU A 1 491 ? -25.490 -49.554 -10.434 1.00 32.85  ? 754  LEU A CG  1 
ATOM   3581 C  CD1 . LEU A 1 491 ? -25.568 -48.570 -11.591 1.00 31.53  ? 754  LEU A CD1 1 
ATOM   3582 C  CD2 . LEU A 1 491 ? -25.025 -48.884 -9.156  1.00 31.50  ? 754  LEU A CD2 1 
ATOM   3583 N  N   . GLY A 1 492 ? -26.239 -53.277 -11.050 1.00 30.21  ? 755  GLY A N   1 
ATOM   3584 C  CA  . GLY A 1 492 ? -25.405 -54.426 -11.419 1.00 27.48  ? 755  GLY A CA  1 
ATOM   3585 C  C   . GLY A 1 492 ? -25.669 -54.863 -12.838 1.00 29.16  ? 755  GLY A C   1 
ATOM   3586 O  O   . GLY A 1 492 ? -24.718 -55.147 -13.595 1.00 27.88  ? 755  GLY A O   1 
ATOM   3587 N  N   . LYS A 1 493 ? -26.944 -54.929 -13.203 1.00 29.50  ? 756  LYS A N   1 
ATOM   3588 C  CA  . LYS A 1 493 ? -27.411 -55.351 -14.550 1.00 27.82  ? 756  LYS A CA  1 
ATOM   3589 C  C   . LYS A 1 493 ? -26.941 -54.361 -15.608 1.00 25.87  ? 756  LYS A C   1 
ATOM   3590 O  O   . LYS A 1 493 ? -26.662 -54.803 -16.721 1.00 30.10  ? 756  LYS A O   1 
ATOM   3591 C  CB  . LYS A 1 493 ? -28.949 -55.439 -14.557 1.00 28.39  ? 756  LYS A CB  1 
ATOM   3592 C  CG  . LYS A 1 493 ? -29.550 -55.972 -15.849 1.00 30.37  ? 756  LYS A CG  1 
ATOM   3593 C  CD  . LYS A 1 493 ? -31.001 -56.399 -15.687 1.00 34.22  ? 756  LYS A CD  1 
ATOM   3594 C  CE  . LYS A 1 493 ? -31.657 -56.747 -17.003 1.00 36.57  ? 756  LYS A CE  1 
ATOM   3595 N  NZ  . LYS A 1 493 ? -32.967 -57.413 -16.782 1.00 39.98  ? 756  LYS A NZ  1 
ATOM   3596 N  N   . SER A 1 494 ? -26.942 -53.057 -15.321 1.00 27.70  ? 757  SER A N   1 
ATOM   3597 C  CA  . SER A 1 494 ? -26.400 -52.032 -16.258 1.00 31.42  ? 757  SER A CA  1 
ATOM   3598 C  C   . SER A 1 494 ? -24.925 -52.359 -16.551 1.00 28.43  ? 757  SER A C   1 
ATOM   3599 O  O   . SER A 1 494 ? -24.558 -52.348 -17.726 1.00 27.21  ? 757  SER A O   1 
ATOM   3600 C  CB  . SER A 1 494 ? -26.497 -50.622 -15.765 1.00 30.90  ? 757  SER A CB  1 
ATOM   3601 O  OG  . SER A 1 494 ? -27.809 -50.313 -15.307 1.00 44.78  ? 757  SER A OG  1 
ATOM   3602 N  N   . TYR A 1 495 ? -24.126 -52.643 -15.533 1.00 25.99  ? 758  TYR A N   1 
ATOM   3603 C  CA  . TYR A 1 495 ? -22.680 -52.999 -15.733 1.00 30.51  ? 758  TYR A CA  1 
ATOM   3604 C  C   . TYR A 1 495 ? -22.544 -54.287 -16.554 1.00 30.05  ? 758  TYR A C   1 
ATOM   3605 O  O   . TYR A 1 495 ? -21.751 -54.321 -17.527 1.00 30.72  ? 758  TYR A O   1 
ATOM   3606 C  CB  . TYR A 1 495 ? -21.958 -53.108 -14.393 1.00 28.12  ? 758  TYR A CB  1 
ATOM   3607 C  CG  . TYR A 1 495 ? -21.468 -51.779 -13.907 1.00 28.77  ? 758  TYR A CG  1 
ATOM   3608 C  CD1 . TYR A 1 495 ? -20.375 -51.180 -14.517 1.00 30.28  ? 758  TYR A CD1 1 
ATOM   3609 C  CD2 . TYR A 1 495 ? -22.092 -51.117 -12.869 1.00 31.67  ? 758  TYR A CD2 1 
ATOM   3610 C  CE1 . TYR A 1 495 ? -19.927 -49.937 -14.128 1.00 29.75  ? 758  TYR A CE1 1 
ATOM   3611 C  CE2 . TYR A 1 495 ? -21.645 -49.874 -12.454 1.00 33.17  ? 758  TYR A CE2 1 
ATOM   3612 C  CZ  . TYR A 1 495 ? -20.552 -49.295 -13.084 1.00 35.07  ? 758  TYR A CZ  1 
ATOM   3613 O  OH  . TYR A 1 495 ? -20.083 -48.087 -12.680 1.00 34.43  ? 758  TYR A OH  1 
ATOM   3614 N  N   . ALA A 1 496 ? -23.343 -55.306 -16.202 1.00 32.60  ? 759  ALA A N   1 
ATOM   3615 C  CA  . ALA A 1 496 ? -23.339 -56.614 -16.883 1.00 29.61  ? 759  ALA A CA  1 
ATOM   3616 C  C   . ALA A 1 496 ? -23.610 -56.404 -18.378 1.00 30.33  ? 759  ALA A C   1 
ATOM   3617 O  O   . ALA A 1 496 ? -22.853 -56.938 -19.210 1.00 29.99  ? 759  ALA A O   1 
ATOM   3618 C  CB  . ALA A 1 496 ? -24.349 -57.508 -16.234 1.00 32.92  ? 759  ALA A CB  1 
ATOM   3619 N  N   . GLN A 1 497 ? -24.649 -55.645 -18.729 1.00 30.34  ? 760  GLN A N   1 
ATOM   3620 C  CA  . GLN A 1 497 ? -25.028 -55.429 -20.165 1.00 31.61  ? 760  GLN A CA  1 
ATOM   3621 C  C   . GLN A 1 497 ? -23.947 -54.564 -20.852 1.00 25.88  ? 760  GLN A C   1 
ATOM   3622 O  O   . GLN A 1 497 ? -23.617 -54.809 -22.040 1.00 25.95  ? 760  GLN A O   1 
ATOM   3623 C  CB  . GLN A 1 497 ? -26.468 -54.887 -20.273 1.00 33.77  ? 760  GLN A CB  1 
ATOM   3624 C  CG  . GLN A 1 497 ? -27.503 -55.849 -19.684 1.00 35.34  ? 760  GLN A CG  1 
ATOM   3625 C  CD  . GLN A 1 497 ? -28.957 -55.599 -20.048 1.00 34.69  ? 760  GLN A CD  1 
ATOM   3626 O  OE1 . GLN A 1 497 ? -29.777 -56.516 -20.027 1.00 35.82  ? 760  GLN A OE1 1 
ATOM   3627 N  NE2 . GLN A 1 497 ? -29.299 -54.371 -20.361 1.00 31.80  ? 760  GLN A NE2 1 
ATOM   3628 N  N   . MET A 1 498 ? -23.328 -53.628 -20.140 1.00 24.42  ? 761  MET A N   1 
ATOM   3629 C  CA  . MET A 1 498 ? -22.204 -52.872 -20.745 1.00 26.00  ? 761  MET A CA  1 
ATOM   3630 C  C   . MET A 1 498 ? -21.077 -53.865 -21.097 1.00 24.35  ? 761  MET A C   1 
ATOM   3631 O  O   . MET A 1 498 ? -20.552 -53.842 -22.225 1.00 24.14  ? 761  MET A O   1 
ATOM   3632 C  CB  . MET A 1 498 ? -21.687 -51.785 -19.816 1.00 27.92  ? 761  MET A CB  1 
ATOM   3633 C  CG  . MET A 1 498 ? -20.509 -51.028 -20.440 1.00 34.55  ? 761  MET A CG  1 
ATOM   3634 S  SD  . MET A 1 498 ? -19.842 -49.829 -19.295 1.00 40.54  ? 761  MET A SD  1 
ATOM   3635 C  CE  . MET A 1 498 ? -19.003 -50.905 -18.145 1.00 40.45  ? 761  MET A CE  1 
ATOM   3636 N  N   . TRP A 1 499 ? -20.767 -54.773 -20.201 1.00 23.34  ? 762  TRP A N   1 
ATOM   3637 C  CA  . TRP A 1 499 ? -19.677 -55.760 -20.402 1.00 25.28  ? 762  TRP A CA  1 
ATOM   3638 C  C   . TRP A 1 499 ? -19.977 -56.676 -21.597 1.00 29.41  ? 762  TRP A C   1 
ATOM   3639 O  O   . TRP A 1 499 ? -19.029 -56.973 -22.378 1.00 31.03  ? 762  TRP A O   1 
ATOM   3640 C  CB  . TRP A 1 499 ? -19.434 -56.582 -19.136 1.00 26.32  ? 762  TRP A CB  1 
ATOM   3641 C  CG  . TRP A 1 499 ? -18.849 -55.855 -17.970 1.00 25.14  ? 762  TRP A CG  1 
ATOM   3642 C  CD1 . TRP A 1 499 ? -18.312 -54.610 -17.959 1.00 26.36  ? 762  TRP A CD1 1 
ATOM   3643 C  CD2 . TRP A 1 499 ? -18.648 -56.384 -16.651 1.00 25.84  ? 762  TRP A CD2 1 
ATOM   3644 N  NE1 . TRP A 1 499 ? -17.922 -54.287 -16.692 1.00 28.07  ? 762  TRP A NE1 1 
ATOM   3645 C  CE2 . TRP A 1 499 ? -18.086 -55.363 -15.878 1.00 24.24  ? 762  TRP A CE2 1 
ATOM   3646 C  CE3 . TRP A 1 499 ? -18.959 -57.589 -16.029 1.00 28.80  ? 762  TRP A CE3 1 
ATOM   3647 C  CZ2 . TRP A 1 499 ? -17.736 -55.531 -14.550 1.00 25.98  ? 762  TRP A CZ2 1 
ATOM   3648 C  CZ3 . TRP A 1 499 ? -18.676 -57.738 -14.691 1.00 27.52  ? 762  TRP A CZ3 1 
ATOM   3649 C  CH2 . TRP A 1 499 ? -18.067 -56.726 -13.968 1.00 28.20  ? 762  TRP A CH2 1 
ATOM   3650 N  N   A SER A 1 500 ? -21.229 -57.136 -21.728 0.25 29.33  ? 763  SER A N   1 
ATOM   3651 N  N   B SER A 1 500 ? -21.227 -57.144 -21.745 0.25 28.67  ? 763  SER A N   1 
ATOM   3652 C  CA  A SER A 1 500 ? -21.671 -58.027 -22.830 0.25 28.94  ? 763  SER A CA  1 
ATOM   3653 C  CA  B SER A 1 500 ? -21.615 -58.059 -22.851 0.25 27.91  ? 763  SER A CA  1 
ATOM   3654 C  C   A SER A 1 500 ? -21.519 -57.302 -24.164 0.25 27.68  ? 763  SER A C   1 
ATOM   3655 C  C   B SER A 1 500 ? -21.549 -57.310 -24.182 0.25 27.18  ? 763  SER A C   1 
ATOM   3656 O  O   A SER A 1 500 ? -21.180 -57.959 -25.152 0.25 29.98  ? 763  SER A O   1 
ATOM   3657 O  O   B SER A 1 500 ? -21.289 -57.963 -25.197 0.25 29.65  ? 763  SER A O   1 
ATOM   3658 C  CB  A SER A 1 500 ? -23.083 -58.502 -22.626 0.25 30.57  ? 763  SER A CB  1 
ATOM   3659 C  CB  B SER A 1 500 ? -22.967 -58.716 -22.639 0.25 28.68  ? 763  SER A CB  1 
ATOM   3660 O  OG  A SER A 1 500 ? -23.251 -58.981 -21.301 0.25 33.06  ? 763  SER A OG  1 
ATOM   3661 O  OG  B SER A 1 500 ? -24.036 -57.809 -22.852 0.25 29.69  ? 763  SER A OG  1 
ATOM   3662 N  N   . LEU A 1 501 ? -21.752 -55.992 -24.177 1.00 28.78  ? 764  LEU A N   1 
ATOM   3663 C  CA  . LEU A 1 501 ? -21.719 -55.179 -25.423 1.00 30.61  ? 764  LEU A CA  1 
ATOM   3664 C  C   . LEU A 1 501 ? -20.307 -54.687 -25.774 1.00 30.93  ? 764  LEU A C   1 
ATOM   3665 O  O   . LEU A 1 501 ? -19.943 -54.673 -26.971 1.00 31.63  ? 764  LEU A O   1 
ATOM   3666 C  CB  . LEU A 1 501 ? -22.683 -54.016 -25.209 1.00 37.45  ? 764  LEU A CB  1 
ATOM   3667 C  CG  . LEU A 1 501 ? -23.392 -53.525 -26.462 1.00 51.34  ? 764  LEU A CG  1 
ATOM   3668 C  CD1 . LEU A 1 501 ? -23.911 -54.690 -27.303 1.00 55.16  ? 764  LEU A CD1 1 
ATOM   3669 C  CD2 . LEU A 1 501 ? -24.535 -52.600 -26.057 1.00 57.30  ? 764  LEU A CD2 1 
ATOM   3670 N  N   . MET A 1 502 ? -19.535 -54.245 -24.795 1.00 28.24  ? 765  MET A N   1 
ATOM   3671 C  CA  . MET A 1 502 ? -18.226 -53.595 -25.058 1.00 30.13  ? 765  MET A CA  1 
ATOM   3672 C  C   . MET A 1 502 ? -17.055 -54.562 -24.787 1.00 29.02  ? 765  MET A C   1 
ATOM   3673 O  O   . MET A 1 502 ? -16.112 -54.454 -25.516 1.00 29.05  ? 765  MET A O   1 
ATOM   3674 C  CB  . MET A 1 502 ? -18.068 -52.338 -24.192 1.00 31.13  ? 765  MET A CB  1 
ATOM   3675 C  CG  . MET A 1 502 ? -19.124 -51.270 -24.428 1.00 30.25  ? 765  MET A CG  1 
ATOM   3676 S  SD  . MET A 1 502 ? -19.074 -50.676 -26.123 1.00 36.03  ? 765  MET A SD  1 
ATOM   3677 C  CE  . MET A 1 502 ? -20.347 -51.629 -26.926 1.00 44.96  ? 765  MET A CE  1 
ATOM   3678 N  N   . TYR A 1 503 ? -17.133 -55.435 -23.777 1.00 26.09  ? 766  TYR A N   1 
ATOM   3679 C  CA  . TYR A 1 503 ? -16.005 -56.202 -23.201 1.00 27.89  ? 766  TYR A CA  1 
ATOM   3680 C  C   . TYR A 1 503 ? -16.224 -57.728 -23.355 1.00 28.73  ? 766  TYR A C   1 
ATOM   3681 O  O   . TYR A 1 503 ? -15.663 -58.547 -22.566 1.00 27.97  ? 766  TYR A O   1 
ATOM   3682 C  CB  . TYR A 1 503 ? -15.816 -55.719 -21.759 1.00 28.41  ? 766  TYR A CB  1 
ATOM   3683 C  CG  . TYR A 1 503 ? -15.594 -54.226 -21.597 1.00 28.64  ? 766  TYR A CG  1 
ATOM   3684 C  CD1 . TYR A 1 503 ? -14.567 -53.555 -22.246 1.00 29.83  ? 766  TYR A CD1 1 
ATOM   3685 C  CD2 . TYR A 1 503 ? -16.395 -53.465 -20.759 1.00 31.01  ? 766  TYR A CD2 1 
ATOM   3686 C  CE1 . TYR A 1 503 ? -14.360 -52.188 -22.081 1.00 28.01  ? 766  TYR A CE1 1 
ATOM   3687 C  CE2 . TYR A 1 503 ? -16.230 -52.092 -20.612 1.00 28.32  ? 766  TYR A CE2 1 
ATOM   3688 C  CZ  . TYR A 1 503 ? -15.204 -51.452 -21.270 1.00 30.16  ? 766  TYR A CZ  1 
ATOM   3689 O  OH  . TYR A 1 503 ? -15.037 -50.120 -21.072 1.00 29.45  ? 766  TYR A OH  1 
ATOM   3690 N  N   . PHE A 1 504 ? -17.030 -58.131 -24.344 1.00 31.09  ? 767  PHE A N   1 
ATOM   3691 C  CA  . PHE A 1 504 ? -17.504 -59.524 -24.571 1.00 28.92  ? 767  PHE A CA  1 
ATOM   3692 C  C   . PHE A 1 504 ? -16.300 -60.433 -24.833 1.00 29.97  ? 767  PHE A C   1 
ATOM   3693 O  O   . PHE A 1 504 ? -16.377 -61.663 -24.624 1.00 26.57  ? 767  PHE A O   1 
ATOM   3694 C  CB  . PHE A 1 504 ? -18.406 -59.636 -25.798 1.00 26.79  ? 767  PHE A CB  1 
ATOM   3695 C  CG  . PHE A 1 504 ? -17.906 -58.895 -27.017 1.00 24.76  ? 767  PHE A CG  1 
ATOM   3696 C  CD1 . PHE A 1 504 ? -18.256 -57.582 -27.237 1.00 24.86  ? 767  PHE A CD1 1 
ATOM   3697 C  CD2 . PHE A 1 504 ? -17.117 -59.517 -27.950 1.00 24.66  ? 767  PHE A CD2 1 
ATOM   3698 C  CE1 . PHE A 1 504 ? -17.791 -56.909 -28.346 1.00 25.13  ? 767  PHE A CE1 1 
ATOM   3699 C  CE2 . PHE A 1 504 ? -16.621 -58.835 -29.045 1.00 23.09  ? 767  PHE A CE2 1 
ATOM   3700 C  CZ  . PHE A 1 504 ? -16.962 -57.531 -29.241 1.00 26.45  ? 767  PHE A CZ  1 
ATOM   3701 N  N   . HIS A 1 505 ? -15.227 -59.814 -25.318 1.00 30.14  ? 768  HIS A N   1 
ATOM   3702 C  CA  . HIS A 1 505 ? -13.960 -60.481 -25.732 1.00 28.58  ? 768  HIS A CA  1 
ATOM   3703 C  C   . HIS A 1 505 ? -13.066 -60.845 -24.531 1.00 30.63  ? 768  HIS A C   1 
ATOM   3704 O  O   . HIS A 1 505 ? -12.002 -61.477 -24.767 1.00 29.64  ? 768  HIS A O   1 
ATOM   3705 C  CB  . HIS A 1 505 ? -13.239 -59.583 -26.721 1.00 28.40  ? 768  HIS A CB  1 
ATOM   3706 C  CG  . HIS A 1 505 ? -13.098 -58.192 -26.229 1.00 28.47  ? 768  HIS A CG  1 
ATOM   3707 N  ND1 . HIS A 1 505 ? -12.044 -57.801 -25.437 1.00 29.03  ? 768  HIS A ND1 1 
ATOM   3708 C  CD2 . HIS A 1 505 ? -13.893 -57.106 -26.387 1.00 33.48  ? 768  HIS A CD2 1 
ATOM   3709 C  CE1 . HIS A 1 505 ? -12.187 -56.530 -25.123 1.00 32.52  ? 768  HIS A CE1 1 
ATOM   3710 N  NE2 . HIS A 1 505 ? -13.343 -56.066 -25.677 1.00 29.28  ? 768  HIS A NE2 1 
ATOM   3711 N  N   . ARG A 1 506 ? -13.430 -60.432 -23.310 1.00 26.00  ? 769  ARG A N   1 
ATOM   3712 C  CA  . ARG A 1 506 ? -12.720 -60.750 -22.051 1.00 25.16  ? 769  ARG A CA  1 
ATOM   3713 C  C   . ARG A 1 506 ? -13.493 -61.915 -21.415 1.00 29.41  ? 769  ARG A C   1 
ATOM   3714 O  O   . ARG A 1 506 ? -14.685 -61.741 -21.065 1.00 30.36  ? 769  ARG A O   1 
ATOM   3715 C  CB  . ARG A 1 506 ? -12.670 -59.526 -21.127 1.00 25.41  ? 769  ARG A CB  1 
ATOM   3716 C  CG  . ARG A 1 506 ? -12.180 -58.242 -21.783 1.00 25.80  ? 769  ARG A CG  1 
ATOM   3717 C  CD  . ARG A 1 506 ? -10.796 -58.361 -22.419 1.00 26.41  ? 769  ARG A CD  1 
ATOM   3718 N  NE  . ARG A 1 506 ? -9.924  -58.893 -21.397 1.00 26.97  ? 769  ARG A NE  1 
ATOM   3719 C  CZ  . ARG A 1 506 ? -9.420  -58.213 -20.376 1.00 27.09  ? 769  ARG A CZ  1 
ATOM   3720 N  NH1 . ARG A 1 506 ? -8.733  -58.851 -19.446 1.00 26.05  ? 769  ARG A NH1 1 
ATOM   3721 N  NH2 . ARG A 1 506 ? -9.550  -56.906 -20.290 1.00 27.09  ? 769  ARG A NH2 1 
ATOM   3722 N  N   . ARG A 1 507 ? -12.836 -63.069 -21.265 0.36 28.60  ? 770  ARG A N   1 
ATOM   3723 C  CA  . ARG A 1 507 ? -13.472 -64.338 -20.824 0.36 27.80  ? 770  ARG A CA  1 
ATOM   3724 C  C   . ARG A 1 507 ? -14.160 -64.134 -19.471 0.36 26.99  ? 770  ARG A C   1 
ATOM   3725 O  O   . ARG A 1 507 ? -15.289 -64.632 -19.317 0.36 26.67  ? 770  ARG A O   1 
ATOM   3726 C  CB  . ARG A 1 507 ? -12.439 -65.465 -20.747 0.36 28.74  ? 770  ARG A CB  1 
ATOM   3727 C  CG  . ARG A 1 507 ? -11.921 -65.921 -22.102 0.36 29.42  ? 770  ARG A CG  1 
ATOM   3728 C  CD  . ARG A 1 507 ? -10.640 -66.730 -21.985 0.36 29.58  ? 770  ARG A CD  1 
ATOM   3729 N  NE  . ARG A 1 507 ? -10.232 -67.245 -23.283 0.36 29.29  ? 770  ARG A NE  1 
ATOM   3730 C  CZ  . ARG A 1 507 ? -9.593  -66.545 -24.216 0.36 30.60  ? 770  ARG A CZ  1 
ATOM   3731 N  NH1 . ARG A 1 507 ? -9.262  -65.282 -24.006 0.36 30.54  ? 770  ARG A NH1 1 
ATOM   3732 N  NH2 . ARG A 1 507 ? -9.277  -67.117 -25.365 0.36 30.90  ? 770  ARG A NH2 1 
ATOM   3733 N  N   . ASP A 1 508 ? -13.517 -63.428 -18.535 1.00 25.49  ? 771  ASP A N   1 
ATOM   3734 C  CA  . ASP A 1 508 ? -14.066 -63.272 -17.165 1.00 25.86  ? 771  ASP A CA  1 
ATOM   3735 C  C   . ASP A 1 508 ? -15.324 -62.374 -17.184 1.00 29.40  ? 771  ASP A C   1 
ATOM   3736 O  O   . ASP A 1 508 ? -16.235 -62.605 -16.359 1.00 27.05  ? 771  ASP A O   1 
ATOM   3737 C  CB  . ASP A 1 508 ? -13.045 -62.740 -16.180 1.00 26.75  ? 771  ASP A CB  1 
ATOM   3738 C  CG  . ASP A 1 508 ? -11.829 -63.619 -15.961 1.00 27.81  ? 771  ASP A CG  1 
ATOM   3739 O  OD1 . ASP A 1 508 ? -11.855 -64.787 -16.373 1.00 26.04  ? 771  ASP A OD1 1 
ATOM   3740 O  OD2 . ASP A 1 508 ? -10.849 -63.095 -15.398 1.00 27.72  ? 771  ASP A OD2 1 
ATOM   3741 N  N   . LEU A 1 509 ? -15.377 -61.392 -18.088 1.00 27.20  ? 772  LEU A N   1 
ATOM   3742 C  CA  . LEU A 1 509 ? -16.452 -60.389 -18.082 1.00 27.79  ? 772  LEU A CA  1 
ATOM   3743 C  C   . LEU A 1 509 ? -17.676 -60.980 -18.797 1.00 28.67  ? 772  LEU A C   1 
ATOM   3744 O  O   . LEU A 1 509 ? -18.764 -60.679 -18.368 1.00 27.55  ? 772  LEU A O   1 
ATOM   3745 C  CB  . LEU A 1 509 ? -15.935 -59.089 -18.714 1.00 28.39  ? 772  LEU A CB  1 
ATOM   3746 C  CG  . LEU A 1 509 ? -14.844 -58.339 -17.918 1.00 27.38  ? 772  LEU A CG  1 
ATOM   3747 C  CD1 . LEU A 1 509 ? -14.661 -56.926 -18.456 1.00 26.48  ? 772  LEU A CD1 1 
ATOM   3748 C  CD2 . LEU A 1 509 ? -15.130 -58.316 -16.413 1.00 27.10  ? 772  LEU A CD2 1 
ATOM   3749 N  N   . ARG A 1 510 ? -17.504 -61.801 -19.840 1.00 30.86  ? 773  ARG A N   1 
ATOM   3750 C  CA  . ARG A 1 510 ? -18.648 -62.455 -20.498 1.00 28.31  ? 773  ARG A CA  1 
ATOM   3751 C  C   . ARG A 1 510 ? -19.278 -63.418 -19.494 1.00 30.77  ? 773  ARG A C   1 
ATOM   3752 O  O   . ARG A 1 510 ? -20.530 -63.500 -19.462 1.00 29.88  ? 773  ARG A O   1 
ATOM   3753 C  CB  . ARG A 1 510 ? -18.262 -63.173 -21.786 1.00 30.49  ? 773  ARG A CB  1 
ATOM   3754 C  CG  . ARG A 1 510 ? -19.486 -63.517 -22.636 1.00 31.33  ? 773  ARG A CG  1 
ATOM   3755 C  CD  . ARG A 1 510 ? -19.244 -64.401 -23.845 1.00 29.24  ? 773  ARG A CD  1 
ATOM   3756 N  NE  . ARG A 1 510 ? -18.300 -63.806 -24.771 1.00 29.34  ? 773  ARG A NE  1 
ATOM   3757 C  CZ  . ARG A 1 510 ? -18.122 -64.182 -26.046 1.00 32.93  ? 773  ARG A CZ  1 
ATOM   3758 N  NH1 . ARG A 1 510 ? -18.865 -65.137 -26.568 1.00 33.64  ? 773  ARG A NH1 1 
ATOM   3759 N  NH2 . ARG A 1 510 ? -17.225 -63.579 -26.817 1.00 30.57  ? 773  ARG A NH2 1 
ATOM   3760 N  N   . LEU A 1 511 ? -18.463 -64.106 -18.690 1.00 28.72  ? 774  LEU A N   1 
ATOM   3761 C  CA  . LEU A 1 511 ? -18.991 -65.078 -17.711 1.00 30.37  ? 774  LEU A CA  1 
ATOM   3762 C  C   . LEU A 1 511 ? -19.671 -64.320 -16.571 1.00 29.00  ? 774  LEU A C   1 
ATOM   3763 O  O   . LEU A 1 511 ? -20.792 -64.697 -16.208 1.00 28.18  ? 774  LEU A O   1 
ATOM   3764 C  CB  . LEU A 1 511 ? -17.892 -66.013 -17.204 1.00 33.11  ? 774  LEU A CB  1 
ATOM   3765 C  CG  . LEU A 1 511 ? -18.391 -67.279 -16.501 1.00 35.13  ? 774  LEU A CG  1 
ATOM   3766 C  CD1 . LEU A 1 511 ? -17.345 -68.373 -16.559 1.00 36.30  ? 774  LEU A CD1 1 
ATOM   3767 C  CD2 . LEU A 1 511 ? -18.762 -67.005 -15.049 1.00 33.93  ? 774  LEU A CD2 1 
ATOM   3768 N  N   . ALA A 1 512 ? -19.057 -63.290 -16.023 1.00 26.02  ? 775  ALA A N   1 
ATOM   3769 C  CA  . ALA A 1 512 ? -19.653 -62.571 -14.880 1.00 27.07  ? 775  ALA A CA  1 
ATOM   3770 C  C   . ALA A 1 512 ? -20.938 -61.830 -15.335 1.00 28.31  ? 775  ALA A C   1 
ATOM   3771 O  O   . ALA A 1 512 ? -21.885 -61.764 -14.555 1.00 30.75  ? 775  ALA A O   1 
ATOM   3772 C  CB  . ALA A 1 512 ? -18.641 -61.667 -14.269 1.00 23.56  ? 775  ALA A CB  1 
ATOM   3773 N  N   . ALA A 1 513 ? -20.986 -61.341 -16.572 1.00 26.61  ? 776  ALA A N   1 
ATOM   3774 C  CA  . ALA A 1 513 ? -22.125 -60.606 -17.155 1.00 27.96  ? 776  ALA A CA  1 
ATOM   3775 C  C   . ALA A 1 513 ? -23.319 -61.560 -17.276 1.00 29.75  ? 776  ALA A C   1 
ATOM   3776 O  O   . ALA A 1 513 ? -24.447 -61.141 -16.933 1.00 30.02  ? 776  ALA A O   1 
ATOM   3777 C  CB  . ALA A 1 513 ? -21.758 -60.031 -18.510 1.00 27.26  ? 776  ALA A CB  1 
ATOM   3778 N  N   . ASN A 1 514 ? -23.074 -62.758 -17.814 1.00 29.38  ? 777  ASN A N   1 
ATOM   3779 C  CA  . ASN A 1 514 ? -24.080 -63.846 -17.910 1.00 31.58  ? 777  ASN A CA  1 
ATOM   3780 C  C   . ASN A 1 514 ? -24.558 -64.216 -16.509 1.00 31.42  ? 777  ASN A C   1 
ATOM   3781 O  O   . ASN A 1 514 ? -25.800 -64.337 -16.313 1.00 33.96  ? 777  ASN A O   1 
ATOM   3782 C  CB  . ASN A 1 514 ? -23.555 -65.061 -18.658 1.00 31.47  ? 777  ASN A CB  1 
ATOM   3783 C  CG  . ASN A 1 514 ? -23.472 -64.791 -20.144 1.00 34.46  ? 777  ASN A CG  1 
ATOM   3784 O  OD1 . ASN A 1 514 ? -24.301 -64.080 -20.697 1.00 36.29  ? 777  ASN A OD1 1 
ATOM   3785 N  ND2 . ASN A 1 514 ? -22.478 -65.354 -20.809 1.00 35.88  ? 777  ASN A ND2 1 
ATOM   3786 N  N   . ALA A 1 515 ? -23.655 -64.348 -15.548 1.00 27.55  ? 778  ALA A N   1 
ATOM   3787 C  CA  . ALA A 1 515 ? -24.044 -64.681 -14.157 1.00 27.23  ? 778  ALA A CA  1 
ATOM   3788 C  C   . ALA A 1 515 ? -24.920 -63.562 -13.583 1.00 29.42  ? 778  ALA A C   1 
ATOM   3789 O  O   . ALA A 1 515 ? -25.920 -63.861 -12.986 1.00 29.41  ? 778  ALA A O   1 
ATOM   3790 C  CB  . ALA A 1 515 ? -22.857 -64.951 -13.285 1.00 25.21  ? 778  ALA A CB  1 
ATOM   3791 N  N   . ILE A 1 516 ? -24.547 -62.298 -13.733 1.00 30.31  ? 779  ILE A N   1 
ATOM   3792 C  CA  . ILE A 1 516 ? -25.341 -61.188 -13.152 1.00 32.33  ? 779  ILE A CA  1 
ATOM   3793 C  C   . ILE A 1 516 ? -26.729 -61.146 -13.827 1.00 33.02  ? 779  ILE A C   1 
ATOM   3794 O  O   . ILE A 1 516 ? -27.699 -61.028 -13.109 1.00 29.17  ? 779  ILE A O   1 
ATOM   3795 C  CB  . ILE A 1 516 ? -24.585 -59.850 -13.246 1.00 31.08  ? 779  ILE A CB  1 
ATOM   3796 C  CG1 . ILE A 1 516 ? -23.337 -59.866 -12.364 1.00 30.11  ? 779  ILE A CG1 1 
ATOM   3797 C  CG2 . ILE A 1 516 ? -25.498 -58.671 -12.906 1.00 27.80  ? 779  ILE A CG2 1 
ATOM   3798 C  CD1 . ILE A 1 516 ? -22.377 -58.752 -12.718 1.00 32.46  ? 779  ILE A CD1 1 
ATOM   3799 N  N   . CYS A 1 517 ? -26.822 -61.225 -15.152 1.00 33.83  ? 780  CYS A N   1 
ATOM   3800 C  CA  . CYS A 1 517 ? -28.119 -61.188 -15.874 1.00 33.85  ? 780  CYS A CA  1 
ATOM   3801 C  C   . CYS A 1 517 ? -28.949 -62.430 -15.532 1.00 36.44  ? 780  CYS A C   1 
ATOM   3802 O  O   . CYS A 1 517 ? -30.156 -62.370 -15.672 1.00 35.42  ? 780  CYS A O   1 
ATOM   3803 C  CB  . CYS A 1 517 ? -27.917 -61.042 -17.374 1.00 31.24  ? 780  CYS A CB  1 
ATOM   3804 S  SG  . CYS A 1 517 ? -27.230 -59.420 -17.772 1.00 35.78  ? 780  CYS A SG  1 
ATOM   3805 N  N   . SER A 1 518 ? -28.326 -63.509 -15.074 1.00 35.19  ? 781  SER A N   1 
ATOM   3806 C  CA  . SER A 1 518 ? -29.044 -64.722 -14.623 1.00 32.15  ? 781  SER A CA  1 
ATOM   3807 C  C   . SER A 1 518 ? -29.565 -64.496 -13.211 1.00 31.44  ? 781  SER A C   1 
ATOM   3808 O  O   . SER A 1 518 ? -30.623 -65.088 -12.877 1.00 35.51  ? 781  SER A O   1 
ATOM   3809 C  CB  . SER A 1 518 ? -28.180 -65.956 -14.693 1.00 32.55  ? 781  SER A CB  1 
ATOM   3810 O  OG  . SER A 1 518 ? -27.904 -66.294 -16.039 1.00 37.67  ? 781  SER A OG  1 
ATOM   3811 N  N   . ALA A 1 519 ? -28.886 -63.659 -12.426 1.00 30.47  ? 782  ALA A N   1 
ATOM   3812 C  CA  . ALA A 1 519 ? -29.154 -63.485 -10.974 1.00 32.07  ? 782  ALA A CA  1 
ATOM   3813 C  C   . ALA A 1 519 ? -30.202 -62.388 -10.738 1.00 30.99  ? 782  ALA A C   1 
ATOM   3814 O  O   . ALA A 1 519 ? -30.748 -62.313 -9.645  1.00 33.75  ? 782  ALA A O   1 
ATOM   3815 C  CB  . ALA A 1 519 ? -27.879 -63.191 -10.226 1.00 34.11  ? 782  ALA A CB  1 
ATOM   3816 N  N   . VAL A 1 520 ? -30.371 -61.501 -11.693 1.00 29.86  ? 783  VAL A N   1 
ATOM   3817 C  CA  . VAL A 1 520 ? -31.318 -60.369 -11.610 1.00 31.78  ? 783  VAL A CA  1 
ATOM   3818 C  C   . VAL A 1 520 ? -32.573 -60.740 -12.410 1.00 31.94  ? 783  VAL A C   1 
ATOM   3819 O  O   . VAL A 1 520 ? -32.485 -61.227 -13.541 1.00 30.91  ? 783  VAL A O   1 
ATOM   3820 C  CB  . VAL A 1 520 ? -30.668 -59.071 -12.118 1.00 34.76  ? 783  VAL A CB  1 
ATOM   3821 C  CG1 . VAL A 1 520 ? -31.630 -57.886 -12.010 1.00 36.17  ? 783  VAL A CG1 1 
ATOM   3822 C  CG2 . VAL A 1 520 ? -29.355 -58.752 -11.384 1.00 32.21  ? 783  VAL A CG2 1 
ATOM   3823 N  N   . PRO A 1 521 ? -33.786 -60.464 -11.873 1.00 31.98  ? 784  PRO A N   1 
ATOM   3824 C  CA  . PRO A 1 521 ? -35.026 -60.801 -12.585 1.00 32.63  ? 784  PRO A CA  1 
ATOM   3825 C  C   . PRO A 1 521 ? -34.981 -60.282 -14.029 1.00 32.94  ? 784  PRO A C   1 
ATOM   3826 O  O   . PRO A 1 521 ? -34.613 -59.139 -14.254 1.00 35.54  ? 784  PRO A O   1 
ATOM   3827 C  CB  . PRO A 1 521 ? -36.126 -60.209 -11.690 1.00 31.76  ? 784  PRO A CB  1 
ATOM   3828 C  CG  . PRO A 1 521 ? -35.521 -60.288 -10.296 1.00 35.42  ? 784  PRO A CG  1 
ATOM   3829 C  CD  . PRO A 1 521 ? -34.040 -59.950 -10.512 1.00 30.99  ? 784  PRO A CD  1 
ATOM   3830 N  N   A SER A 1 522 ? -35.344 -61.155 -14.971 0.25 33.52  ? 785  SER A N   1 
ATOM   3831 N  N   B SER A 1 522 ? -35.374 -61.146 -14.970 0.25 33.34  ? 785  SER A N   1 
ATOM   3832 C  CA  A SER A 1 522 ? -35.270 -60.958 -16.442 0.25 35.88  ? 785  SER A CA  1 
ATOM   3833 C  CA  B SER A 1 522 ? -35.267 -60.965 -16.441 0.25 35.55  ? 785  SER A CA  1 
ATOM   3834 C  C   A SER A 1 522 ? -35.856 -59.608 -16.859 0.25 37.16  ? 785  SER A C   1 
ATOM   3835 C  C   B SER A 1 522 ? -35.873 -59.630 -16.885 0.25 36.96  ? 785  SER A C   1 
ATOM   3836 O  O   A SER A 1 522 ? -35.217 -58.922 -17.679 0.25 36.66  ? 785  SER A O   1 
ATOM   3837 O  O   B SER A 1 522 ? -35.261 -58.971 -17.747 0.25 36.47  ? 785  SER A O   1 
ATOM   3838 C  CB  A SER A 1 522 ? -35.988 -62.072 -17.142 0.25 38.32  ? 785  SER A CB  1 
ATOM   3839 C  CB  B SER A 1 522 ? -35.925 -62.113 -17.170 0.25 37.69  ? 785  SER A CB  1 
ATOM   3840 O  OG  A SER A 1 522 ? -37.363 -62.065 -16.790 0.25 40.58  ? 785  SER A OG  1 
ATOM   3841 O  OG  B SER A 1 522 ? -35.874 -63.310 -16.405 0.25 39.40  ? 785  SER A OG  1 
ATOM   3842 N  N   . HIS A 1 523 ? -37.040 -59.257 -16.342 1.00 36.87  ? 786  HIS A N   1 
ATOM   3843 C  CA  . HIS A 1 523 ? -37.779 -58.037 -16.778 1.00 37.47  ? 786  HIS A CA  1 
ATOM   3844 C  C   . HIS A 1 523 ? -37.338 -56.765 -16.052 1.00 36.97  ? 786  HIS A C   1 
ATOM   3845 O  O   . HIS A 1 523 ? -37.773 -55.684 -16.500 1.00 41.20  ? 786  HIS A O   1 
ATOM   3846 C  CB  . HIS A 1 523 ? -39.293 -58.292 -16.712 1.00 39.89  ? 786  HIS A CB  1 
ATOM   3847 C  CG  . HIS A 1 523 ? -39.702 -59.359 -17.670 1.00 42.00  ? 786  HIS A CG  1 
ATOM   3848 N  ND1 . HIS A 1 523 ? -39.746 -59.140 -19.036 1.00 42.02  ? 786  HIS A ND1 1 
ATOM   3849 C  CD2 . HIS A 1 523 ? -40.019 -60.663 -17.475 1.00 48.62  ? 786  HIS A CD2 1 
ATOM   3850 C  CE1 . HIS A 1 523 ? -40.098 -60.259 -19.644 1.00 45.46  ? 786  HIS A CE1 1 
ATOM   3851 N  NE2 . HIS A 1 523 ? -40.289 -61.215 -18.705 1.00 48.54  ? 786  HIS A NE2 1 
ATOM   3852 N  N   . TRP A 1 524 ? -36.479 -56.829 -15.028 1.00 37.94  ? 787  TRP A N   1 
ATOM   3853 C  CA  . TRP A 1 524 ? -36.074 -55.607 -14.275 1.00 36.77  ? 787  TRP A CA  1 
ATOM   3854 C  C   . TRP A 1 524 ? -35.181 -54.738 -15.156 1.00 36.83  ? 787  TRP A C   1 
ATOM   3855 O  O   . TRP A 1 524 ? -34.360 -55.279 -15.895 1.00 37.17  ? 787  TRP A O   1 
ATOM   3856 C  CB  . TRP A 1 524 ? -35.418 -55.968 -12.946 1.00 38.52  ? 787  TRP A CB  1 
ATOM   3857 C  CG  . TRP A 1 524 ? -36.409 -56.436 -11.930 1.00 38.97  ? 787  TRP A CG  1 
ATOM   3858 C  CD1 . TRP A 1 524 ? -37.739 -56.708 -12.123 1.00 40.62  ? 787  TRP A CD1 1 
ATOM   3859 C  CD2 . TRP A 1 524 ? -36.148 -56.708 -10.546 1.00 39.23  ? 787  TRP A CD2 1 
ATOM   3860 N  NE1 . TRP A 1 524 ? -38.314 -57.132 -10.955 1.00 38.62  ? 787  TRP A NE1 1 
ATOM   3861 C  CE2 . TRP A 1 524 ? -37.368 -57.122 -9.965  1.00 37.33  ? 787  TRP A CE2 1 
ATOM   3862 C  CE3 . TRP A 1 524 ? -35.006 -56.635 -9.748  1.00 37.48  ? 787  TRP A CE3 1 
ATOM   3863 C  CZ2 . TRP A 1 524 ? -37.475 -57.453 -8.617  1.00 38.01  ? 787  TRP A CZ2 1 
ATOM   3864 C  CZ3 . TRP A 1 524 ? -35.116 -56.976 -8.418  1.00 40.79  ? 787  TRP A CZ3 1 
ATOM   3865 C  CH2 . TRP A 1 524 ? -36.328 -57.376 -7.862  1.00 37.02  ? 787  TRP A CH2 1 
ATOM   3866 N  N   . VAL A 1 525 ? -35.386 -53.434 -15.099 1.00 34.74  ? 788  VAL A N   1 
ATOM   3867 C  CA  . VAL A 1 525 ? -34.815 -52.476 -16.078 1.00 38.87  ? 788  VAL A CA  1 
ATOM   3868 C  C   . VAL A 1 525 ? -33.482 -51.974 -15.520 1.00 37.77  ? 788  VAL A C   1 
ATOM   3869 O  O   . VAL A 1 525 ? -33.372 -51.536 -14.375 1.00 40.39  ? 788  VAL A O   1 
ATOM   3870 C  CB  . VAL A 1 525 ? -35.803 -51.324 -16.371 1.00 41.46  ? 788  VAL A CB  1 
ATOM   3871 C  CG1 . VAL A 1 525 ? -35.244 -50.333 -17.385 1.00 41.73  ? 788  VAL A CG1 1 
ATOM   3872 C  CG2 . VAL A 1 525 ? -37.170 -51.834 -16.823 1.00 41.95  ? 788  VAL A CG2 1 
ATOM   3873 N  N   . PRO A 1 526 ? -32.410 -52.027 -16.319 1.00 40.63  ? 789  PRO A N   1 
ATOM   3874 C  CA  . PRO A 1 526 ? -31.149 -51.394 -15.938 1.00 41.76  ? 789  PRO A CA  1 
ATOM   3875 C  C   . PRO A 1 526 ? -31.239 -49.881 -15.671 1.00 44.36  ? 789  PRO A C   1 
ATOM   3876 O  O   . PRO A 1 526 ? -31.921 -49.200 -16.410 1.00 42.80  ? 789  PRO A O   1 
ATOM   3877 C  CB  . PRO A 1 526 ? -30.274 -51.592 -17.169 1.00 40.32  ? 789  PRO A CB  1 
ATOM   3878 C  CG  . PRO A 1 526 ? -30.935 -52.639 -18.029 1.00 40.46  ? 789  PRO A CG  1 
ATOM   3879 C  CD  . PRO A 1 526 ? -32.373 -52.735 -17.604 1.00 40.62  ? 789  PRO A CD  1 
ATOM   3880 N  N   . THR A 1 527 ? -30.583 -49.416 -14.602 0.48 46.12  ? 790  THR A N   1 
ATOM   3881 C  CA  . THR A 1 527 ? -30.514 -47.989 -14.183 0.48 49.84  ? 790  THR A CA  1 
ATOM   3882 C  C   . THR A 1 527 ? -29.051 -47.587 -13.988 0.48 47.07  ? 790  THR A C   1 
ATOM   3883 O  O   . THR A 1 527 ? -28.379 -48.324 -13.253 0.48 41.28  ? 790  THR A O   1 
ATOM   3884 C  CB  . THR A 1 527 ? -31.293 -47.747 -12.885 0.48 55.18  ? 790  THR A CB  1 
ATOM   3885 O  OG1 . THR A 1 527 ? -30.679 -48.500 -11.836 0.48 61.82  ? 790  THR A OG1 1 
ATOM   3886 C  CG2 . THR A 1 527 ? -32.750 -48.130 -13.001 0.48 55.24  ? 790  THR A CG2 1 
ATOM   3887 N  N   . ILE A 1 534 ? -19.073 -38.221 -22.123 1.00 117.85 ? 797  ILE A N   1 
ATOM   3888 C  CA  . ILE A 1 534 ? -19.784 -37.436 -23.182 1.00 118.96 ? 797  ILE A CA  1 
ATOM   3889 C  C   . ILE A 1 534 ? -19.260 -37.842 -24.582 1.00 118.81 ? 797  ILE A C   1 
ATOM   3890 O  O   . ILE A 1 534 ? -19.679 -37.208 -25.569 1.00 107.35 ? 797  ILE A O   1 
ATOM   3891 C  CB  . ILE A 1 534 ? -19.683 -35.912 -22.900 1.00 114.83 ? 797  ILE A CB  1 
ATOM   3892 C  CG1 . ILE A 1 534 ? -19.892 -35.549 -21.422 1.00 110.79 ? 797  ILE A CG1 1 
ATOM   3893 C  CG2 . ILE A 1 534 ? -20.643 -35.121 -23.778 1.00 110.60 ? 797  ILE A CG2 1 
ATOM   3894 C  CD1 . ILE A 1 534 ? -21.273 -35.877 -20.877 1.00 106.84 ? 797  ILE A CD1 1 
ATOM   3895 N  N   . HIS A 1 535 ? -18.411 -38.882 -24.682 1.00 127.17 ? 798  HIS A N   1 
ATOM   3896 C  CA  . HIS A 1 535 ? -18.032 -39.585 -25.948 1.00 127.77 ? 798  HIS A CA  1 
ATOM   3897 C  C   . HIS A 1 535 ? -18.972 -40.783 -26.228 1.00 144.92 ? 798  HIS A C   1 
ATOM   3898 O  O   . HIS A 1 535 ? -18.870 -41.332 -27.359 1.00 134.44 ? 798  HIS A O   1 
ATOM   3899 C  CB  . HIS A 1 535 ? -16.539 -40.012 -25.937 1.00 105.72 ? 798  HIS A CB  1 
ATOM   3900 C  CG  . HIS A 1 535 ? -16.180 -41.113 -24.979 1.00 99.92  ? 798  HIS A CG  1 
ATOM   3901 N  ND1 . HIS A 1 535 ? -16.802 -42.365 -24.981 1.00 90.63  ? 798  HIS A ND1 1 
ATOM   3902 C  CD2 . HIS A 1 535 ? -15.255 -41.170 -23.992 1.00 90.48  ? 798  HIS A CD2 1 
ATOM   3903 C  CE1 . HIS A 1 535 ? -16.289 -43.120 -24.026 1.00 87.26  ? 798  HIS A CE1 1 
ATOM   3904 N  NE2 . HIS A 1 535 ? -15.334 -42.415 -23.409 1.00 89.35  ? 798  HIS A NE2 1 
ATOM   3905 N  N   . ALA A 1 536 ? -19.857 -41.153 -25.273 1.00 150.80 ? 799  ALA A N   1 
ATOM   3906 C  CA  . ALA A 1 536 ? -20.580 -42.457 -25.175 1.00 140.59 ? 799  ALA A CA  1 
ATOM   3907 C  C   . ALA A 1 536 ? -22.065 -42.315 -25.566 1.00 129.68 ? 799  ALA A C   1 
ATOM   3908 O  O   . ALA A 1 536 ? -22.532 -41.162 -25.690 1.00 132.62 ? 799  ALA A O   1 
ATOM   3909 C  CB  . ALA A 1 536 ? -20.427 -43.022 -23.777 1.00 134.86 ? 799  ALA A CB  1 
ATOM   3910 N  N   . THR A 1 537 ? -22.786 -43.436 -25.760 1.00 109.86 ? 800  THR A N   1 
ATOM   3911 C  CA  . THR A 1 537 ? -24.206 -43.435 -26.226 1.00 103.92 ? 800  THR A CA  1 
ATOM   3912 C  C   . THR A 1 537 ? -25.073 -44.569 -25.630 1.00 102.55 ? 800  THR A C   1 
ATOM   3913 O  O   . THR A 1 537 ? -26.305 -44.519 -25.852 1.00 107.80 ? 800  THR A O   1 
ATOM   3914 C  CB  . THR A 1 537 ? -24.263 -43.416 -27.758 1.00 103.13 ? 800  THR A CB  1 
ATOM   3915 O  OG1 . THR A 1 537 ? -23.505 -44.506 -28.284 1.00 95.90  ? 800  THR A OG1 1 
ATOM   3916 C  CG2 . THR A 1 537 ? -23.744 -42.116 -28.330 1.00 103.88 ? 800  THR A CG2 1 
ATOM   3917 N  N   . HIS A 1 538 ? -24.507 -45.553 -24.922 1.00 86.48  ? 801  HIS A N   1 
ATOM   3918 C  CA  . HIS A 1 538 ? -25.214 -46.338 -23.869 1.00 67.54  ? 801  HIS A CA  1 
ATOM   3919 C  C   . HIS A 1 538 ? -26.304 -47.254 -24.440 1.00 52.67  ? 801  HIS A C   1 
ATOM   3920 O  O   . HIS A 1 538 ? -27.415 -47.325 -23.844 1.00 45.96  ? 801  HIS A O   1 
ATOM   3921 C  CB  . HIS A 1 538 ? -25.755 -45.374 -22.815 1.00 70.89  ? 801  HIS A CB  1 
ATOM   3922 C  CG  . HIS A 1 538 ? -24.641 -44.759 -22.050 1.00 80.56  ? 801  HIS A CG  1 
ATOM   3923 N  ND1 . HIS A 1 538 ? -24.737 -44.481 -20.704 1.00 86.67  ? 801  HIS A ND1 1 
ATOM   3924 C  CD2 . HIS A 1 538 ? -23.386 -44.429 -22.430 1.00 78.78  ? 801  HIS A CD2 1 
ATOM   3925 C  CE1 . HIS A 1 538 ? -23.596 -43.968 -20.287 1.00 89.01  ? 801  HIS A CE1 1 
ATOM   3926 N  NE2 . HIS A 1 538 ? -22.746 -43.924 -21.332 1.00 85.01  ? 801  HIS A NE2 1 
ATOM   3927 N  N   . GLU A 1 539 ? -25.965 -48.038 -25.462 1.00 42.60  ? 802  GLU A N   1 
ATOM   3928 C  CA  . GLU A 1 539 ? -26.901 -49.017 -26.053 1.00 45.51  ? 802  GLU A CA  1 
ATOM   3929 C  C   . GLU A 1 539 ? -27.216 -50.158 -25.075 1.00 44.74  ? 802  GLU A C   1 
ATOM   3930 O  O   . GLU A 1 539 ? -28.142 -50.934 -25.386 1.00 44.75  ? 802  GLU A O   1 
ATOM   3931 C  CB  . GLU A 1 539 ? -26.359 -49.575 -27.359 1.00 50.07  ? 802  GLU A CB  1 
ATOM   3932 C  CG  . GLU A 1 539 ? -26.620 -48.681 -28.553 1.00 56.30  ? 802  GLU A CG  1 
ATOM   3933 C  CD  . GLU A 1 539 ? -25.534 -47.651 -28.765 1.00 63.11  ? 802  GLU A CD  1 
ATOM   3934 O  OE1 . GLU A 1 539 ? -25.528 -47.018 -29.848 1.00 72.08  ? 802  GLU A OE1 1 
ATOM   3935 O  OE2 . GLU A 1 539 ? -24.700 -47.492 -27.836 1.00 60.39  ? 802  GLU A OE2 1 
ATOM   3936 N  N   . TRP A 1 540 ? -26.515 -50.265 -23.943 1.00 37.95  ? 803  TRP A N   1 
ATOM   3937 C  CA  . TRP A 1 540 ? -26.740 -51.363 -22.962 1.00 39.34  ? 803  TRP A CA  1 
ATOM   3938 C  C   . TRP A 1 540 ? -27.895 -51.071 -22.006 1.00 39.62  ? 803  TRP A C   1 
ATOM   3939 O  O   . TRP A 1 540 ? -28.321 -51.981 -21.301 1.00 39.58  ? 803  TRP A O   1 
ATOM   3940 C  CB  . TRP A 1 540 ? -25.446 -51.700 -22.191 1.00 37.28  ? 803  TRP A CB  1 
ATOM   3941 C  CG  . TRP A 1 540 ? -24.813 -50.565 -21.445 1.00 34.92  ? 803  TRP A CG  1 
ATOM   3942 C  CD1 . TRP A 1 540 ? -25.062 -50.187 -20.157 1.00 36.28  ? 803  TRP A CD1 1 
ATOM   3943 C  CD2 . TRP A 1 540 ? -23.787 -49.680 -21.931 1.00 33.20  ? 803  TRP A CD2 1 
ATOM   3944 N  NE1 . TRP A 1 540 ? -24.267 -49.120 -19.811 1.00 36.24  ? 803  TRP A NE1 1 
ATOM   3945 C  CE2 . TRP A 1 540 ? -23.479 -48.784 -20.881 1.00 35.34  ? 803  TRP A CE2 1 
ATOM   3946 C  CE3 . TRP A 1 540 ? -23.110 -49.541 -23.150 1.00 36.16  ? 803  TRP A CE3 1 
ATOM   3947 C  CZ2 . TRP A 1 540 ? -22.505 -47.787 -21.013 1.00 37.69  ? 803  TRP A CZ2 1 
ATOM   3948 C  CZ3 . TRP A 1 540 ? -22.153 -48.557 -23.282 1.00 38.88  ? 803  TRP A CZ3 1 
ATOM   3949 C  CH2 . TRP A 1 540 ? -21.850 -47.693 -22.225 1.00 38.16  ? 803  TRP A CH2 1 
ATOM   3950 N  N   . MET A 1 541 ? -28.373 -49.822 -21.976 0.40 43.23  ? 804  MET A N   1 
ATOM   3951 C  CA  . MET A 1 541 ? -29.510 -49.379 -21.126 0.40 45.19  ? 804  MET A CA  1 
ATOM   3952 C  C   . MET A 1 541 ? -30.819 -49.706 -21.856 0.40 43.97  ? 804  MET A C   1 
ATOM   3953 O  O   . MET A 1 541 ? -31.364 -48.811 -22.532 0.40 43.92  ? 804  MET A O   1 
ATOM   3954 C  CB  . MET A 1 541 ? -29.427 -47.877 -20.829 0.40 49.25  ? 804  MET A CB  1 
ATOM   3955 C  CG  . MET A 1 541 ? -28.083 -47.450 -20.259 0.40 52.33  ? 804  MET A CG  1 
ATOM   3956 S  SD  . MET A 1 541 ? -28.049 -45.731 -19.673 0.40 57.91  ? 804  MET A SD  1 
ATOM   3957 C  CE  . MET A 1 541 ? -29.027 -44.914 -20.936 0.40 57.51  ? 804  MET A CE  1 
ATOM   3958 N  N   . THR A 1 542 ? -31.287 -50.951 -21.722 1.00 41.09  ? 805  THR A N   1 
ATOM   3959 C  CA  . THR A 1 542 ? -32.468 -51.489 -22.443 1.00 44.78  ? 805  THR A CA  1 
ATOM   3960 C  C   . THR A 1 542 ? -32.812 -52.844 -21.836 1.00 45.19  ? 805  THR A C   1 
ATOM   3961 O  O   . THR A 1 542 ? -31.916 -53.429 -21.177 1.00 40.37  ? 805  THR A O   1 
ATOM   3962 C  CB  . THR A 1 542 ? -32.214 -51.668 -23.950 1.00 52.00  ? 805  THR A CB  1 
ATOM   3963 O  OG1 . THR A 1 542 ? -33.222 -52.526 -24.493 1.00 50.02  ? 805  THR A OG1 1 
ATOM   3964 C  CG2 . THR A 1 542 ? -30.869 -52.290 -24.267 1.00 53.24  ? 805  THR A CG2 1 
ATOM   3965 N  N   . THR A 1 543 ? -34.038 -53.320 -22.078 1.00 39.78  ? 806  THR A N   1 
ATOM   3966 C  CA  . THR A 1 543 ? -34.522 -54.686 -21.709 1.00 45.23  ? 806  THR A CA  1 
ATOM   3967 C  C   . THR A 1 543 ? -34.524 -55.603 -22.941 1.00 39.90  ? 806  THR A C   1 
ATOM   3968 O  O   . THR A 1 543 ? -34.784 -56.803 -22.773 1.00 40.10  ? 806  THR A O   1 
ATOM   3969 C  CB  . THR A 1 543 ? -35.915 -54.619 -21.061 1.00 50.19  ? 806  THR A CB  1 
ATOM   3970 O  OG1 . THR A 1 543 ? -36.708 -53.783 -21.907 1.00 45.69  ? 806  THR A OG1 1 
ATOM   3971 C  CG2 . THR A 1 543 ? -35.865 -54.084 -19.640 1.00 52.21  ? 806  THR A CG2 1 
ATOM   3972 N  N   . GLU A 1 544 ? -34.178 -55.077 -24.117 1.00 38.80  ? 807  GLU A N   1 
ATOM   3973 C  CA  . GLU A 1 544 ? -34.021 -55.879 -25.355 1.00 39.06  ? 807  GLU A CA  1 
ATOM   3974 C  C   . GLU A 1 544 ? -32.932 -56.943 -25.156 1.00 40.58  ? 807  GLU A C   1 
ATOM   3975 O  O   . GLU A 1 544 ? -32.077 -56.798 -24.258 1.00 38.62  ? 807  GLU A O   1 
ATOM   3976 C  CB  . GLU A 1 544 ? -33.721 -54.944 -26.518 1.00 43.71  ? 807  GLU A CB  1 
ATOM   3977 C  CG  . GLU A 1 544 ? -33.704 -55.636 -27.854 1.00 51.25  ? 807  GLU A CG  1 
ATOM   3978 C  CD  . GLU A 1 544 ? -33.675 -54.662 -29.020 1.00 60.93  ? 807  GLU A CD  1 
ATOM   3979 O  OE1 . GLU A 1 544 ? -34.176 -55.047 -30.115 1.00 68.30  ? 807  GLU A OE1 1 
ATOM   3980 O  OE2 . GLU A 1 544 ? -33.161 -53.518 -28.836 1.00 52.35  ? 807  GLU A OE2 1 
ATOM   3981 N  N   . ASP A 1 545 ? -33.013 -58.023 -25.923 1.00 41.95  ? 808  ASP A N   1 
ATOM   3982 C  CA  . ASP A 1 545 ? -32.097 -59.186 -25.834 1.00 46.62  ? 808  ASP A CA  1 
ATOM   3983 C  C   . ASP A 1 545 ? -30.687 -58.703 -26.192 1.00 40.16  ? 808  ASP A C   1 
ATOM   3984 O  O   . ASP A 1 545 ? -30.555 -58.040 -27.232 1.00 36.95  ? 808  ASP A O   1 
ATOM   3985 C  CB  . ASP A 1 545 ? -32.549 -60.300 -26.783 1.00 54.47  ? 808  ASP A CB  1 
ATOM   3986 C  CG  . ASP A 1 545 ? -31.723 -61.569 -26.706 1.00 62.23  ? 808  ASP A CG  1 
ATOM   3987 O  OD1 . ASP A 1 545 ? -30.489 -61.460 -26.613 1.00 77.54  ? 808  ASP A OD1 1 
ATOM   3988 O  OD2 . ASP A 1 545 ? -32.328 -62.663 -26.740 1.00 86.28  ? 808  ASP A OD2 1 
ATOM   3989 N  N   . MET A 1 546 ? -29.666 -59.078 -25.416 1.00 37.74  ? 809  MET A N   1 
ATOM   3990 C  CA  . MET A 1 546 ? -28.306 -58.502 -25.630 1.00 36.96  ? 809  MET A CA  1 
ATOM   3991 C  C   . MET A 1 546 ? -27.699 -58.946 -26.970 1.00 33.68  ? 809  MET A C   1 
ATOM   3992 O  O   . MET A 1 546 ? -26.980 -58.149 -27.570 1.00 34.32  ? 809  MET A O   1 
ATOM   3993 C  CB  . MET A 1 546 ? -27.349 -58.716 -24.453 1.00 37.64  ? 809  MET A CB  1 
ATOM   3994 C  CG  . MET A 1 546 ? -27.549 -57.693 -23.314 1.00 39.49  ? 809  MET A CG  1 
ATOM   3995 S  SD  . MET A 1 546 ? -27.447 -55.924 -23.815 1.00 47.87  ? 809  MET A SD  1 
ATOM   3996 C  CE  . MET A 1 546 ? -29.130 -55.412 -23.532 1.00 55.47  ? 809  MET A CE  1 
ATOM   3997 N  N   . LEU A 1 547 ? -27.997 -60.157 -27.449 0.50 33.89  ? 810  LEU A N   1 
ATOM   3998 C  CA  . LEU A 1 547 ? -27.475 -60.610 -28.769 0.50 35.88  ? 810  LEU A CA  1 
ATOM   3999 C  C   . LEU A 1 547 ? -28.066 -59.742 -29.887 0.50 36.68  ? 810  LEU A C   1 
ATOM   4000 O  O   . LEU A 1 547 ? -27.340 -59.486 -30.866 0.50 36.87  ? 810  LEU A O   1 
ATOM   4001 C  CB  . LEU A 1 547 ? -27.783 -62.087 -29.017 0.50 36.90  ? 810  LEU A CB  1 
ATOM   4002 C  CG  . LEU A 1 547 ? -27.147 -62.648 -30.289 0.50 38.30  ? 810  LEU A CG  1 
ATOM   4003 C  CD1 . LEU A 1 547 ? -25.634 -62.475 -30.260 0.50 38.76  ? 810  LEU A CD1 1 
ATOM   4004 C  CD2 . LEU A 1 547 ? -27.506 -64.110 -30.485 0.50 39.98  ? 810  LEU A CD2 1 
ATOM   4005 N  N   . THR A 1 548 ? -29.327 -59.313 -29.755 1.00 35.12  ? 811  THR A N   1 
ATOM   4006 C  CA  . THR A 1 548 ? -29.991 -58.443 -30.770 1.00 37.21  ? 811  THR A CA  1 
ATOM   4007 C  C   . THR A 1 548 ? -29.304 -57.069 -30.809 1.00 33.73  ? 811  THR A C   1 
ATOM   4008 O  O   . THR A 1 548 ? -29.029 -56.588 -31.901 1.00 32.48  ? 811  THR A O   1 
ATOM   4009 C  CB  . THR A 1 548 ? -31.507 -58.309 -30.536 1.00 40.31  ? 811  THR A CB  1 
ATOM   4010 O  OG1 . THR A 1 548 ? -32.051 -59.623 -30.646 1.00 41.58  ? 811  THR A OG1 1 
ATOM   4011 C  CG2 . THR A 1 548 ? -32.197 -57.386 -31.521 1.00 40.18  ? 811  THR A CG2 1 
ATOM   4012 N  N   . VAL A 1 549 ? -29.121 -56.442 -29.657 1.00 30.85  ? 812  VAL A N   1 
ATOM   4013 C  CA  . VAL A 1 549 ? -28.338 -55.189 -29.512 1.00 38.11  ? 812  VAL A CA  1 
ATOM   4014 C  C   . VAL A 1 549 ? -26.908 -55.388 -30.043 1.00 35.89  ? 812  VAL A C   1 
ATOM   4015 O  O   . VAL A 1 549 ? -26.414 -54.480 -30.741 1.00 36.21  ? 812  VAL A O   1 
ATOM   4016 C  CB  . VAL A 1 549 ? -28.290 -54.710 -28.055 1.00 38.97  ? 812  VAL A CB  1 
ATOM   4017 C  CG1 . VAL A 1 549 ? -27.514 -53.395 -27.997 1.00 37.58  ? 812  VAL A CG1 1 
ATOM   4018 C  CG2 . VAL A 1 549 ? -29.695 -54.572 -27.467 1.00 42.86  ? 812  VAL A CG2 1 
ATOM   4019 N  N   . TRP A 1 550 ? -26.244 -56.503 -29.726 1.00 33.85  ? 813  TRP A N   1 
ATOM   4020 C  CA  . TRP A 1 550 ? -24.851 -56.731 -30.204 1.00 33.03  ? 813  TRP A CA  1 
ATOM   4021 C  C   . TRP A 1 550 ? -24.846 -56.643 -31.740 1.00 37.07  ? 813  TRP A C   1 
ATOM   4022 O  O   . TRP A 1 550 ? -24.018 -55.907 -32.301 1.00 36.98  ? 813  TRP A O   1 
ATOM   4023 C  CB  . TRP A 1 550 ? -24.272 -58.042 -29.668 1.00 30.01  ? 813  TRP A CB  1 
ATOM   4024 C  CG  . TRP A 1 550 ? -22.805 -58.207 -29.906 1.00 31.21  ? 813  TRP A CG  1 
ATOM   4025 C  CD1 . TRP A 1 550 ? -21.806 -58.010 -28.990 1.00 33.38  ? 813  TRP A CD1 1 
ATOM   4026 C  CD2 . TRP A 1 550 ? -22.148 -58.589 -31.124 1.00 31.22  ? 813  TRP A CD2 1 
ATOM   4027 N  NE1 . TRP A 1 550 ? -20.579 -58.266 -29.544 1.00 34.09  ? 813  TRP A NE1 1 
ATOM   4028 C  CE2 . TRP A 1 550 ? -20.752 -58.586 -30.862 1.00 33.95  ? 813  TRP A CE2 1 
ATOM   4029 C  CE3 . TRP A 1 550 ? -22.586 -58.973 -32.389 1.00 32.37  ? 813  TRP A CE3 1 
ATOM   4030 C  CZ2 . TRP A 1 550 ? -19.807 -58.919 -31.822 1.00 32.20  ? 813  TRP A CZ2 1 
ATOM   4031 C  CZ3 . TRP A 1 550 ? -21.651 -59.297 -33.349 1.00 32.24  ? 813  TRP A CZ3 1 
ATOM   4032 C  CH2 . TRP A 1 550 ? -20.285 -59.280 -33.064 1.00 33.87  ? 813  TRP A CH2 1 
ATOM   4033 N  N   . ASN A 1 551 ? -25.760 -57.367 -32.393 0.50 36.61  ? 814  ASN A N   1 
ATOM   4034 C  CA  . ASN A 1 551 ? -25.885 -57.428 -33.875 0.50 38.89  ? 814  ASN A CA  1 
ATOM   4035 C  C   . ASN A 1 551 ? -26.144 -56.024 -34.433 0.50 37.91  ? 814  ASN A C   1 
ATOM   4036 O  O   . ASN A 1 551 ? -25.552 -55.688 -35.477 0.50 37.22  ? 814  ASN A O   1 
ATOM   4037 C  CB  . ASN A 1 551 ? -26.975 -58.406 -34.320 0.50 40.63  ? 814  ASN A CB  1 
ATOM   4038 C  CG  . ASN A 1 551 ? -26.465 -59.824 -34.462 0.50 43.60  ? 814  ASN A CG  1 
ATOM   4039 O  OD1 . ASN A 1 551 ? -25.556 -60.086 -35.249 0.50 45.34  ? 814  ASN A OD1 1 
ATOM   4040 N  ND2 . ASN A 1 551 ? -27.044 -60.747 -33.708 0.50 44.49  ? 814  ASN A ND2 1 
ATOM   4041 N  N   . ARG A 1 552 ? -26.989 -55.231 -33.769 1.00 37.20  ? 815  ARG A N   1 
ATOM   4042 C  CA  . ARG A 1 552 ? -27.300 -53.856 -34.250 1.00 40.06  ? 815  ARG A CA  1 
ATOM   4043 C  C   . ARG A 1 552 ? -26.015 -52.993 -34.204 1.00 41.41  ? 815  ARG A C   1 
ATOM   4044 O  O   . ARG A 1 552 ? -25.676 -52.330 -35.240 1.00 43.17  ? 815  ARG A O   1 
ATOM   4045 C  CB  . ARG A 1 552 ? -28.450 -53.272 -33.432 1.00 38.51  ? 815  ARG A CB  1 
ATOM   4046 C  CG  . ARG A 1 552 ? -28.955 -51.927 -33.936 1.00 41.50  ? 815  ARG A CG  1 
ATOM   4047 C  CD  . ARG A 1 552 ? -29.921 -51.366 -32.909 1.00 47.73  ? 815  ARG A CD  1 
ATOM   4048 N  NE  . ARG A 1 552 ? -31.043 -52.296 -32.858 1.00 56.28  ? 815  ARG A NE  1 
ATOM   4049 C  CZ  . ARG A 1 552 ? -31.699 -52.713 -31.769 1.00 58.85  ? 815  ARG A CZ  1 
ATOM   4050 N  NH1 . ARG A 1 552 ? -31.375 -52.297 -30.551 1.00 55.28  ? 815  ARG A NH1 1 
ATOM   4051 N  NH2 . ARG A 1 552 ? -32.710 -53.551 -31.934 1.00 64.27  ? 815  ARG A NH2 1 
ATOM   4052 N  N   . VAL A 1 553 ? -25.303 -53.040 -33.072 1.00 38.22  ? 816  VAL A N   1 
ATOM   4053 C  CA  . VAL A 1 553 ? -24.151 -52.149 -32.745 1.00 39.40  ? 816  VAL A CA  1 
ATOM   4054 C  C   . VAL A 1 553 ? -22.910 -52.560 -33.560 1.00 35.27  ? 816  VAL A C   1 
ATOM   4055 O  O   . VAL A 1 553 ? -22.282 -51.662 -34.168 1.00 39.32  ? 816  VAL A O   1 
ATOM   4056 C  CB  . VAL A 1 553 ? -23.894 -52.121 -31.226 1.00 38.46  ? 816  VAL A CB  1 
ATOM   4057 C  CG1 . VAL A 1 553 ? -22.543 -51.532 -30.876 1.00 36.63  ? 816  VAL A CG1 1 
ATOM   4058 C  CG2 . VAL A 1 553 ? -24.993 -51.366 -30.510 1.00 36.83  ? 816  VAL A CG2 1 
ATOM   4059 N  N   . TRP A 1 554 ? -22.579 -53.849 -33.604 1.00 32.46  ? 817  TRP A N   1 
ATOM   4060 C  CA  . TRP A 1 554 ? -21.288 -54.353 -34.143 1.00 29.36  ? 817  TRP A CA  1 
ATOM   4061 C  C   . TRP A 1 554 ? -21.422 -54.728 -35.621 1.00 34.69  ? 817  TRP A C   1 
ATOM   4062 O  O   . TRP A 1 554 ? -20.384 -54.782 -36.275 1.00 32.41  ? 817  TRP A O   1 
ATOM   4063 C  CB  . TRP A 1 554 ? -20.754 -55.506 -33.283 1.00 29.61  ? 817  TRP A CB  1 
ATOM   4064 C  CG  . TRP A 1 554 ? -20.242 -55.051 -31.949 1.00 31.82  ? 817  TRP A CG  1 
ATOM   4065 C  CD1 . TRP A 1 554 ? -20.822 -55.194 -30.723 1.00 30.08  ? 817  TRP A CD1 1 
ATOM   4066 C  CD2 . TRP A 1 554 ? -19.017 -54.318 -31.726 1.00 27.98  ? 817  TRP A CD2 1 
ATOM   4067 N  NE1 . TRP A 1 554 ? -20.026 -54.629 -29.754 1.00 30.57  ? 817  TRP A NE1 1 
ATOM   4068 C  CE2 . TRP A 1 554 ? -18.916 -54.079 -30.344 1.00 28.13  ? 817  TRP A CE2 1 
ATOM   4069 C  CE3 . TRP A 1 554 ? -18.001 -53.860 -32.563 1.00 29.06  ? 817  TRP A CE3 1 
ATOM   4070 C  CZ2 . TRP A 1 554 ? -17.841 -53.383 -29.789 1.00 28.73  ? 817  TRP A CZ2 1 
ATOM   4071 C  CZ3 . TRP A 1 554 ? -16.933 -53.160 -32.015 1.00 28.73  ? 817  TRP A CZ3 1 
ATOM   4072 C  CH2 . TRP A 1 554 ? -16.861 -52.923 -30.645 1.00 26.72  ? 817  TRP A CH2 1 
ATOM   4073 N  N   . ILE A 1 555 ? -22.638 -54.998 -36.137 1.00 36.60  ? 818  ILE A N   1 
ATOM   4074 C  CA  . ILE A 1 555 ? -22.829 -55.464 -37.548 1.00 36.61  ? 818  ILE A CA  1 
ATOM   4075 C  C   . ILE A 1 555 ? -23.672 -54.435 -38.302 1.00 39.96  ? 818  ILE A C   1 
ATOM   4076 O  O   . ILE A 1 555 ? -23.136 -53.761 -39.185 1.00 37.36  ? 818  ILE A O   1 
ATOM   4077 C  CB  . ILE A 1 555 ? -23.484 -56.855 -37.639 1.00 38.70  ? 818  ILE A CB  1 
ATOM   4078 C  CG1 . ILE A 1 555 ? -22.791 -57.906 -36.773 1.00 41.15  ? 818  ILE A CG1 1 
ATOM   4079 C  CG2 . ILE A 1 555 ? -23.536 -57.295 -39.089 1.00 39.22  ? 818  ILE A CG2 1 
ATOM   4080 C  CD1 . ILE A 1 555 ? -21.371 -58.150 -37.168 1.00 46.89  ? 818  ILE A CD1 1 
ATOM   4081 N  N   . GLN A 1 556 ? -24.956 -54.323 -37.951 1.00 43.05  ? 819  GLN A N   1 
ATOM   4082 C  CA  . GLN A 1 556 ? -25.975 -53.616 -38.770 1.00 43.25  ? 819  GLN A CA  1 
ATOM   4083 C  C   . GLN A 1 556 ? -25.564 -52.152 -38.927 1.00 37.49  ? 819  GLN A C   1 
ATOM   4084 O  O   . GLN A 1 556 ? -25.484 -51.696 -40.064 1.00 36.73  ? 819  GLN A O   1 
ATOM   4085 C  CB  . GLN A 1 556 ? -27.348 -53.783 -38.123 1.00 48.75  ? 819  GLN A CB  1 
ATOM   4086 C  CG  . GLN A 1 556 ? -28.501 -53.323 -38.997 1.00 58.04  ? 819  GLN A CG  1 
ATOM   4087 C  CD  . GLN A 1 556 ? -29.764 -53.092 -38.196 1.00 66.06  ? 819  GLN A CD  1 
ATOM   4088 O  OE1 . GLN A 1 556 ? -30.357 -52.016 -38.248 1.00 77.74  ? 819  GLN A OE1 1 
ATOM   4089 N  NE2 . GLN A 1 556 ? -30.179 -54.087 -37.422 1.00 63.51  ? 819  GLN A NE2 1 
ATOM   4090 N  N   . GLU A 1 557 ? -25.281 -51.466 -37.819 1.00 38.31  ? 820  GLU A N   1 
ATOM   4091 C  CA  . GLU A 1 557 ? -25.067 -50.002 -37.770 1.00 41.40  ? 820  GLU A CA  1 
ATOM   4092 C  C   . GLU A 1 557 ? -23.566 -49.664 -37.881 1.00 45.20  ? 820  GLU A C   1 
ATOM   4093 O  O   . GLU A 1 557 ? -23.220 -48.449 -37.827 1.00 43.53  ? 820  GLU A O   1 
ATOM   4094 C  CB  . GLU A 1 557 ? -25.654 -49.440 -36.471 1.00 44.52  ? 820  GLU A CB  1 
ATOM   4095 C  CG  . GLU A 1 557 ? -27.159 -49.567 -36.356 1.00 52.05  ? 820  GLU A CG  1 
ATOM   4096 C  CD  . GLU A 1 557 ? -27.767 -48.815 -35.167 1.00 67.77  ? 820  GLU A CD  1 
ATOM   4097 O  OE1 . GLU A 1 557 ? -27.046 -48.623 -34.135 1.00 74.04  ? 820  GLU A OE1 1 
ATOM   4098 O  OE2 . GLU A 1 557 ? -28.971 -48.422 -35.256 1.00 76.24  ? 820  GLU A OE2 1 
ATOM   4099 N  N   . ASN A 1 558 ? -22.690 -50.662 -38.054 1.00 40.46  ? 821  ASN A N   1 
ATOM   4100 C  CA  . ASN A 1 558 ? -21.212 -50.463 -37.983 1.00 35.31  ? 821  ASN A CA  1 
ATOM   4101 C  C   . ASN A 1 558 ? -20.731 -50.088 -39.376 1.00 34.03  ? 821  ASN A C   1 
ATOM   4102 O  O   . ASN A 1 558 ? -20.641 -50.937 -40.247 1.00 33.26  ? 821  ASN A O   1 
ATOM   4103 C  CB  . ASN A 1 558 ? -20.541 -51.718 -37.409 1.00 34.06  ? 821  ASN A CB  1 
ATOM   4104 C  CG  . ASN A 1 558 ? -19.024 -51.708 -37.402 1.00 32.71  ? 821  ASN A CG  1 
ATOM   4105 O  OD1 . ASN A 1 558 ? -18.416 -50.757 -37.860 1.00 32.09  ? 821  ASN A OD1 1 
ATOM   4106 N  ND2 . ASN A 1 558 ? -18.413 -52.778 -36.896 1.00 30.87  ? 821  ASN A ND2 1 
ATOM   4107 N  N   . PRO A 1 559 ? -20.389 -48.818 -39.655 1.00 38.11  ? 822  PRO A N   1 
ATOM   4108 C  CA  . PRO A 1 559 ? -19.966 -48.440 -40.999 1.00 39.72  ? 822  PRO A CA  1 
ATOM   4109 C  C   . PRO A 1 559 ? -18.650 -49.092 -41.446 1.00 41.76  ? 822  PRO A C   1 
ATOM   4110 O  O   . PRO A 1 559 ? -18.350 -49.026 -42.615 1.00 43.70  ? 822  PRO A O   1 
ATOM   4111 C  CB  . PRO A 1 559 ? -19.785 -46.911 -40.923 1.00 42.77  ? 822  PRO A CB  1 
ATOM   4112 C  CG  . PRO A 1 559 ? -19.591 -46.621 -39.449 1.00 40.60  ? 822  PRO A CG  1 
ATOM   4113 C  CD  . PRO A 1 559 ? -20.369 -47.689 -38.718 1.00 38.10  ? 822  PRO A CD  1 
ATOM   4114 N  N   . TRP A 1 560 ? -17.883 -49.712 -40.552 1.00 39.29  ? 823  TRP A N   1 
ATOM   4115 C  CA  . TRP A 1 560 ? -16.615 -50.372 -40.975 1.00 41.47  ? 823  TRP A CA  1 
ATOM   4116 C  C   . TRP A 1 560 ? -16.827 -51.850 -41.337 1.00 42.95  ? 823  TRP A C   1 
ATOM   4117 O  O   . TRP A 1 560 ? -15.835 -52.483 -41.706 1.00 43.17  ? 823  TRP A O   1 
ATOM   4118 C  CB  . TRP A 1 560 ? -15.555 -50.196 -39.893 1.00 39.84  ? 823  TRP A CB  1 
ATOM   4119 C  CG  . TRP A 1 560 ? -15.094 -48.778 -39.781 1.00 36.61  ? 823  TRP A CG  1 
ATOM   4120 C  CD1 . TRP A 1 560 ? -14.149 -48.154 -40.543 1.00 34.36  ? 823  TRP A CD1 1 
ATOM   4121 C  CD2 . TRP A 1 560 ? -15.581 -47.794 -38.853 1.00 34.29  ? 823  TRP A CD2 1 
ATOM   4122 N  NE1 . TRP A 1 560 ? -14.009 -46.851 -40.138 1.00 36.65  ? 823  TRP A NE1 1 
ATOM   4123 C  CE2 . TRP A 1 560 ? -14.872 -46.602 -39.100 1.00 34.99  ? 823  TRP A CE2 1 
ATOM   4124 C  CE3 . TRP A 1 560 ? -16.509 -47.815 -37.812 1.00 35.04  ? 823  TRP A CE3 1 
ATOM   4125 C  CZ2 . TRP A 1 560 ? -15.070 -45.445 -38.343 1.00 35.08  ? 823  TRP A CZ2 1 
ATOM   4126 C  CZ3 . TRP A 1 560 ? -16.743 -46.660 -37.102 1.00 33.68  ? 823  TRP A CZ3 1 
ATOM   4127 C  CH2 . TRP A 1 560 ? -16.030 -45.491 -37.362 1.00 34.27  ? 823  TRP A CH2 1 
ATOM   4128 N  N   . MET A 1 561 ? -18.059 -52.370 -41.240 1.00 42.06  ? 824  MET A N   1 
ATOM   4129 C  CA  . MET A 1 561 ? -18.425 -53.786 -41.537 1.00 43.55  ? 824  MET A CA  1 
ATOM   4130 C  C   . MET A 1 561 ? -19.208 -53.808 -42.859 1.00 43.07  ? 824  MET A C   1 
ATOM   4131 O  O   . MET A 1 561 ? -20.321 -53.275 -42.874 1.00 41.86  ? 824  MET A O   1 
ATOM   4132 C  CB  . MET A 1 561 ? -19.304 -54.321 -40.399 1.00 48.64  ? 824  MET A CB  1 
ATOM   4133 C  CG  . MET A 1 561 ? -19.524 -55.814 -40.389 1.00 51.60  ? 824  MET A CG  1 
ATOM   4134 S  SD  . MET A 1 561 ? -18.018 -56.644 -39.938 1.00 66.79  ? 824  MET A SD  1 
ATOM   4135 C  CE  . MET A 1 561 ? -18.173 -56.686 -38.154 1.00 65.66  ? 824  MET A CE  1 
ATOM   4136 N  N   . GLU A 1 562 ? -18.644 -54.332 -43.946 1.00 47.28  ? 825  GLU A N   1 
ATOM   4137 C  CA  . GLU A 1 562 ? -19.324 -54.375 -45.276 1.00 53.88  ? 825  GLU A CA  1 
ATOM   4138 C  C   . GLU A 1 562 ? -20.436 -55.435 -45.243 1.00 51.45  ? 825  GLU A C   1 
ATOM   4139 O  O   . GLU A 1 562 ? -21.568 -55.106 -45.590 1.00 50.55  ? 825  GLU A O   1 
ATOM   4140 C  CB  . GLU A 1 562 ? -18.327 -54.668 -46.399 1.00 63.49  ? 825  GLU A CB  1 
ATOM   4141 C  CG  . GLU A 1 562 ? -18.796 -54.248 -47.787 1.00 77.96  ? 825  GLU A CG  1 
ATOM   4142 C  CD  . GLU A 1 562 ? -17.723 -54.236 -48.879 1.00 95.04  ? 825  GLU A CD  1 
ATOM   4143 O  OE1 . GLU A 1 562 ? -18.098 -54.375 -50.067 1.00 105.65 ? 825  GLU A OE1 1 
ATOM   4144 O  OE2 . GLU A 1 562 ? -16.512 -54.067 -48.557 1.00 99.50  ? 825  GLU A OE2 1 
ATOM   4145 N  N   . ASP A 1 563 ? -20.112 -56.643 -44.798 1.00 47.18  ? 826  ASP A N   1 
ATOM   4146 C  CA  . ASP A 1 563 ? -21.018 -57.814 -44.773 1.00 47.77  ? 826  ASP A CA  1 
ATOM   4147 C  C   . ASP A 1 563 ? -21.928 -57.741 -43.541 1.00 44.38  ? 826  ASP A C   1 
ATOM   4148 O  O   . ASP A 1 563 ? -21.405 -57.810 -42.432 1.00 45.91  ? 826  ASP A O   1 
ATOM   4149 C  CB  . ASP A 1 563 ? -20.182 -59.091 -44.799 1.00 48.63  ? 826  ASP A CB  1 
ATOM   4150 C  CG  . ASP A 1 563 ? -20.988 -60.319 -44.418 1.00 48.74  ? 826  ASP A CG  1 
ATOM   4151 O  OD1 . ASP A 1 563 ? -22.209 -60.186 -44.276 1.00 46.42  ? 826  ASP A OD1 1 
ATOM   4152 O  OD2 . ASP A 1 563 ? -20.374 -61.369 -44.202 1.00 49.88  ? 826  ASP A OD2 1 
ATOM   4153 N  N   . LYS A 1 564 ? -23.244 -57.641 -43.743 1.00 43.44  ? 827  LYS A N   1 
ATOM   4154 C  CA  . LYS A 1 564 ? -24.254 -57.397 -42.673 1.00 41.67  ? 827  LYS A CA  1 
ATOM   4155 C  C   . LYS A 1 564 ? -24.915 -58.708 -42.225 1.00 39.81  ? 827  LYS A C   1 
ATOM   4156 O  O   . LYS A 1 564 ? -25.979 -58.634 -41.589 1.00 40.27  ? 827  LYS A O   1 
ATOM   4157 C  CB  . LYS A 1 564 ? -25.330 -56.400 -43.129 1.00 44.28  ? 827  LYS A CB  1 
ATOM   4158 C  CG  . LYS A 1 564 ? -24.801 -55.038 -43.569 1.00 41.72  ? 827  LYS A CG  1 
ATOM   4159 C  CD  . LYS A 1 564 ? -23.887 -54.407 -42.568 1.00 40.93  ? 827  LYS A CD  1 
ATOM   4160 C  CE  . LYS A 1 564 ? -23.709 -52.926 -42.769 1.00 43.89  ? 827  LYS A CE  1 
ATOM   4161 N  NZ  . LYS A 1 564 ? -22.853 -52.314 -41.725 1.00 45.11  ? 827  LYS A NZ  1 
ATOM   4162 N  N   . THR A 1 565 ? -24.292 -59.859 -42.471 1.00 39.58  ? 828  THR A N   1 
ATOM   4163 C  CA  . THR A 1 565 ? -24.828 -61.177 -42.034 1.00 42.55  ? 828  THR A CA  1 
ATOM   4164 C  C   . THR A 1 565 ? -24.965 -61.174 -40.518 1.00 42.30  ? 828  THR A C   1 
ATOM   4165 O  O   . THR A 1 565 ? -23.951 -61.112 -39.823 1.00 42.49  ? 828  THR A O   1 
ATOM   4166 C  CB  . THR A 1 565 ? -23.905 -62.333 -42.432 1.00 46.93  ? 828  THR A CB  1 
ATOM   4167 O  OG1 . THR A 1 565 ? -23.654 -62.252 -43.832 1.00 51.73  ? 828  THR A OG1 1 
ATOM   4168 C  CG2 . THR A 1 565 ? -24.474 -63.690 -42.091 1.00 49.49  ? 828  THR A CG2 1 
ATOM   4169 N  N   . PRO A 1 566 ? -26.184 -61.305 -39.942 1.00 47.01  ? 829  PRO A N   1 
ATOM   4170 C  CA  . PRO A 1 566 ? -26.319 -61.295 -38.491 1.00 45.03  ? 829  PRO A CA  1 
ATOM   4171 C  C   . PRO A 1 566 ? -25.577 -62.497 -37.893 1.00 47.12  ? 829  PRO A C   1 
ATOM   4172 O  O   . PRO A 1 566 ? -25.339 -63.493 -38.583 1.00 46.76  ? 829  PRO A O   1 
ATOM   4173 C  CB  . PRO A 1 566 ? -27.829 -61.394 -38.221 1.00 45.64  ? 829  PRO A CB  1 
ATOM   4174 C  CG  . PRO A 1 566 ? -28.488 -61.131 -39.564 1.00 44.88  ? 829  PRO A CG  1 
ATOM   4175 C  CD  . PRO A 1 566 ? -27.472 -61.550 -40.607 1.00 43.57  ? 829  PRO A CD  1 
ATOM   4176 N  N   . VAL A 1 567 ? -25.195 -62.377 -36.620 0.50 46.57  ? 830  VAL A N   1 
ATOM   4177 C  CA  . VAL A 1 567 ? -24.642 -63.490 -35.794 0.50 46.99  ? 830  VAL A CA  1 
ATOM   4178 C  C   . VAL A 1 567 ? -25.823 -64.145 -35.063 0.50 47.57  ? 830  VAL A C   1 
ATOM   4179 O  O   . VAL A 1 567 ? -26.648 -63.399 -34.492 0.50 46.53  ? 830  VAL A O   1 
ATOM   4180 C  CB  . VAL A 1 567 ? -23.565 -62.971 -34.822 0.50 48.19  ? 830  VAL A CB  1 
ATOM   4181 C  CG1 . VAL A 1 567 ? -23.517 -63.792 -33.548 0.50 49.49  ? 830  VAL A CG1 1 
ATOM   4182 C  CG2 . VAL A 1 567 ? -22.191 -62.908 -35.470 0.50 47.47  ? 830  VAL A CG2 1 
ATOM   4183 N  N   . GLU A 1 568 ? -25.910 -65.478 -35.105 0.50 48.10  ? 831  GLU A N   1 
ATOM   4184 C  CA  . GLU A 1 568 ? -27.084 -66.265 -34.631 0.50 49.97  ? 831  GLU A CA  1 
ATOM   4185 C  C   . GLU A 1 568 ? -26.897 -66.695 -33.170 0.50 49.40  ? 831  GLU A C   1 
ATOM   4186 O  O   . GLU A 1 568 ? -27.917 -67.018 -32.536 0.50 48.64  ? 831  GLU A O   1 
ATOM   4187 C  CB  . GLU A 1 568 ? -27.302 -67.492 -35.522 0.50 51.49  ? 831  GLU A CB  1 
ATOM   4188 C  CG  . GLU A 1 568 ? -27.712 -67.144 -36.945 0.50 52.76  ? 831  GLU A CG  1 
ATOM   4189 C  CD  . GLU A 1 568 ? -29.044 -66.415 -37.048 0.50 55.02  ? 831  GLU A CD  1 
ATOM   4190 O  OE1 . GLU A 1 568 ? -29.898 -66.635 -36.170 0.50 54.51  ? 831  GLU A OE1 1 
ATOM   4191 O  OE2 . GLU A 1 568 ? -29.224 -65.623 -37.999 0.50 56.57  ? 831  GLU A OE2 1 
ATOM   4192 N  N   . SER A 1 569 ? -25.656 -66.732 -32.664 1.00 46.60  ? 832  SER A N   1 
ATOM   4193 C  CA  . SER A 1 569 ? -25.373 -67.099 -31.248 1.00 44.21  ? 832  SER A CA  1 
ATOM   4194 C  C   . SER A 1 569 ? -24.109 -66.426 -30.701 1.00 44.43  ? 832  SER A C   1 
ATOM   4195 O  O   . SER A 1 569 ? -23.235 -65.985 -31.479 1.00 40.56  ? 832  SER A O   1 
ATOM   4196 C  CB  . SER A 1 569 ? -25.256 -68.586 -31.098 1.00 42.58  ? 832  SER A CB  1 
ATOM   4197 O  OG  . SER A 1 569 ? -23.976 -69.024 -31.476 1.00 39.74  ? 832  SER A OG  1 
ATOM   4198 N  N   . TRP A 1 570 ? -24.004 -66.394 -29.379 1.00 38.71  ? 833  TRP A N   1 
ATOM   4199 C  CA  . TRP A 1 570 ? -22.852 -65.781 -28.684 1.00 42.04  ? 833  TRP A CA  1 
ATOM   4200 C  C   . TRP A 1 570 ? -21.573 -66.568 -29.015 1.00 42.27  ? 833  TRP A C   1 
ATOM   4201 O  O   . TRP A 1 570 ? -20.490 -65.972 -29.121 1.00 40.92  ? 833  TRP A O   1 
ATOM   4202 C  CB  . TRP A 1 570 ? -23.158 -65.709 -27.187 1.00 39.43  ? 833  TRP A CB  1 
ATOM   4203 C  CG  . TRP A 1 570 ? -24.027 -64.559 -26.805 1.00 40.15  ? 833  TRP A CG  1 
ATOM   4204 C  CD1 . TRP A 1 570 ? -25.350 -64.604 -26.474 1.00 38.77  ? 833  TRP A CD1 1 
ATOM   4205 C  CD2 . TRP A 1 570 ? -23.620 -63.180 -26.664 1.00 41.91  ? 833  TRP A CD2 1 
ATOM   4206 N  NE1 . TRP A 1 570 ? -25.794 -63.354 -26.139 1.00 38.70  ? 833  TRP A NE1 1 
ATOM   4207 C  CE2 . TRP A 1 570 ? -24.760 -62.460 -26.243 1.00 38.16  ? 833  TRP A CE2 1 
ATOM   4208 C  CE3 . TRP A 1 570 ? -22.408 -62.491 -26.828 1.00 38.57  ? 833  TRP A CE3 1 
ATOM   4209 C  CZ2 . TRP A 1 570 ? -24.721 -61.085 -25.993 1.00 40.99  ? 833  TRP A CZ2 1 
ATOM   4210 C  CZ3 . TRP A 1 570 ? -22.371 -61.140 -26.566 1.00 40.77  ? 833  TRP A CZ3 1 
ATOM   4211 C  CH2 . TRP A 1 570 ? -23.516 -60.443 -26.170 1.00 40.69  ? 833  TRP A CH2 1 
ATOM   4212 N  N   . GLU A 1 571 ? -21.681 -67.862 -29.270 1.00 44.95  ? 834  GLU A N   1 
ATOM   4213 C  CA  . GLU A 1 571 ? -20.486 -68.680 -29.572 1.00 50.08  ? 834  GLU A CA  1 
ATOM   4214 C  C   . GLU A 1 571 ? -19.825 -68.231 -30.880 1.00 42.59  ? 834  GLU A C   1 
ATOM   4215 O  O   . GLU A 1 571 ? -18.646 -68.485 -31.003 1.00 43.32  ? 834  GLU A O   1 
ATOM   4216 C  CB  . GLU A 1 571 ? -20.862 -70.158 -29.537 1.00 58.68  ? 834  GLU A CB  1 
ATOM   4217 C  CG  . GLU A 1 571 ? -21.131 -70.627 -28.114 1.00 72.87  ? 834  GLU A CG  1 
ATOM   4218 C  CD  . GLU A 1 571 ? -21.598 -72.070 -27.967 1.00 87.27  ? 834  GLU A CD  1 
ATOM   4219 O  OE1 . GLU A 1 571 ? -21.078 -72.941 -28.716 1.00 95.84  ? 834  GLU A OE1 1 
ATOM   4220 O  OE2 . GLU A 1 571 ? -22.488 -72.325 -27.104 1.00 96.02  ? 834  GLU A OE2 1 
ATOM   4221 N  N   . GLU A 1 572 ? -20.535 -67.595 -31.813 1.00 44.56  ? 835  GLU A N   1 
ATOM   4222 C  CA  . GLU A 1 572 ? -19.928 -66.999 -33.047 1.00 46.09  ? 835  GLU A CA  1 
ATOM   4223 C  C   . GLU A 1 572 ? -19.037 -65.783 -32.700 1.00 44.18  ? 835  GLU A C   1 
ATOM   4224 O  O   . GLU A 1 572 ? -18.307 -65.299 -33.599 1.00 40.66  ? 835  GLU A O   1 
ATOM   4225 C  CB  . GLU A 1 572 ? -20.989 -66.462 -34.009 1.00 46.86  ? 835  GLU A CB  1 
ATOM   4226 C  CG  . GLU A 1 572 ? -21.490 -67.424 -35.063 1.00 55.65  ? 835  GLU A CG  1 
ATOM   4227 C  CD  . GLU A 1 572 ? -22.598 -66.838 -35.951 1.00 57.75  ? 835  GLU A CD  1 
ATOM   4228 O  OE1 . GLU A 1 572 ? -22.273 -66.160 -36.943 1.00 59.03  ? 835  GLU A OE1 1 
ATOM   4229 O  OE2 . GLU A 1 572 ? -23.799 -67.043 -35.646 1.00 58.96  ? 835  GLU A OE2 1 
ATOM   4230 N  N   . ILE A 1 573 ? -19.171 -65.233 -31.487 1.00 39.63  ? 836  ILE A N   1 
ATOM   4231 C  CA  . ILE A 1 573 ? -18.543 -63.943 -31.078 1.00 38.30  ? 836  ILE A CA  1 
ATOM   4232 C  C   . ILE A 1 573 ? -17.223 -64.268 -30.372 1.00 36.76  ? 836  ILE A C   1 
ATOM   4233 O  O   . ILE A 1 573 ? -17.185 -64.932 -29.333 1.00 35.16  ? 836  ILE A O   1 
ATOM   4234 C  CB  . ILE A 1 573 ? -19.519 -63.111 -30.224 1.00 37.22  ? 836  ILE A CB  1 
ATOM   4235 C  CG1 . ILE A 1 573 ? -20.713 -62.653 -31.056 1.00 35.79  ? 836  ILE A CG1 1 
ATOM   4236 C  CG2 . ILE A 1 573 ? -18.808 -61.932 -29.580 1.00 42.65  ? 836  ILE A CG2 1 
ATOM   4237 C  CD1 . ILE A 1 573 ? -21.807 -62.019 -30.244 1.00 37.65  ? 836  ILE A CD1 1 
ATOM   4238 N  N   . PRO A 1 574 ? -16.083 -63.810 -30.917 1.00 34.74  ? 837  PRO A N   1 
ATOM   4239 C  CA  . PRO A 1 574 ? -14.782 -64.267 -30.436 1.00 35.71  ? 837  PRO A CA  1 
ATOM   4240 C  C   . PRO A 1 574 ? -14.295 -63.620 -29.133 1.00 32.74  ? 837  PRO A C   1 
ATOM   4241 O  O   . PRO A 1 574 ? -14.851 -62.661 -28.677 1.00 31.46  ? 837  PRO A O   1 
ATOM   4242 C  CB  . PRO A 1 574 ? -13.848 -63.846 -31.573 1.00 36.00  ? 837  PRO A CB  1 
ATOM   4243 C  CG  . PRO A 1 574 ? -14.492 -62.568 -32.068 1.00 40.97  ? 837  PRO A CG  1 
ATOM   4244 C  CD  . PRO A 1 574 ? -15.985 -62.812 -31.984 1.00 38.04  ? 837  PRO A CD  1 
ATOM   4245 N  N   . TYR A 1 575 ? -13.237 -64.197 -28.560 0.36 33.27  ? 838  TYR A N   1 
ATOM   4246 C  CA  . TYR A 1 575 ? -12.481 -63.657 -27.401 0.36 32.84  ? 838  TYR A CA  1 
ATOM   4247 C  C   . TYR A 1 575 ? -11.093 -63.202 -27.874 0.36 31.80  ? 838  TYR A C   1 
ATOM   4248 O  O   . TYR A 1 575 ? -10.683 -63.585 -28.988 0.36 31.64  ? 838  TYR A O   1 
ATOM   4249 C  CB  . TYR A 1 575 ? -12.331 -64.721 -26.312 0.36 33.19  ? 838  TYR A CB  1 
ATOM   4250 C  CG  . TYR A 1 575 ? -13.609 -65.227 -25.696 0.36 33.14  ? 838  TYR A CG  1 
ATOM   4251 C  CD1 . TYR A 1 575 ? -14.194 -64.577 -24.622 0.36 32.87  ? 838  TYR A CD1 1 
ATOM   4252 C  CD2 . TYR A 1 575 ? -14.210 -66.389 -26.153 0.36 34.53  ? 838  TYR A CD2 1 
ATOM   4253 C  CE1 . TYR A 1 575 ? -15.353 -65.053 -24.032 0.36 33.32  ? 838  TYR A CE1 1 
ATOM   4254 C  CE2 . TYR A 1 575 ? -15.369 -66.881 -25.575 0.36 34.13  ? 838  TYR A CE2 1 
ATOM   4255 C  CZ  . TYR A 1 575 ? -15.943 -66.211 -24.510 0.36 34.71  ? 838  TYR A CZ  1 
ATOM   4256 O  OH  . TYR A 1 575 ? -17.090 -66.694 -23.950 0.36 34.63  ? 838  TYR A OH  1 
ATOM   4257 N  N   . LEU A 1 576 ? -10.387 -62.424 -27.047 0.36 30.21  ? 839  LEU A N   1 
ATOM   4258 C  CA  . LEU A 1 576 ? -8.942  -62.116 -27.224 0.36 29.92  ? 839  LEU A CA  1 
ATOM   4259 C  C   . LEU A 1 576 ? -8.151  -63.420 -27.075 0.36 29.35  ? 839  LEU A C   1 
ATOM   4260 O  O   . LEU A 1 576 ? -8.703  -64.386 -26.491 0.36 29.60  ? 839  LEU A O   1 
ATOM   4261 C  CB  . LEU A 1 576 ? -8.483  -61.105 -26.168 0.36 29.25  ? 839  LEU A CB  1 
ATOM   4262 C  CG  . LEU A 1 576 ? -9.157  -59.736 -26.212 0.36 29.48  ? 839  LEU A CG  1 
ATOM   4263 C  CD1 . LEU A 1 576 ? -8.666  -58.864 -25.069 0.36 29.24  ? 839  LEU A CD1 1 
ATOM   4264 C  CD2 . LEU A 1 576 ? -8.925  -59.050 -27.551 0.36 29.46  ? 839  LEU A CD2 1 
ATOM   4265 N  N   . GLY A 1 577 ? -6.901  -63.438 -27.546 0.36 29.11  ? 840  GLY A N   1 
ATOM   4266 C  CA  . GLY A 1 577 ? -5.959  -64.543 -27.282 0.36 28.05  ? 840  GLY A CA  1 
ATOM   4267 C  C   . GLY A 1 577 ? -5.894  -64.840 -25.783 0.36 27.07  ? 840  GLY A C   1 
ATOM   4268 O  O   . GLY A 1 577 ? -5.939  -63.844 -24.947 0.36 27.10  ? 840  GLY A O   1 
ATOM   4269 N  N   . LYS A 1 578 ? -5.857  -66.149 -25.443 0.36 26.86  ? 841  LYS A N   1 
ATOM   4270 C  CA  . LYS A 1 578 ? -5.736  -66.641 -24.043 0.36 27.15  ? 841  LYS A CA  1 
ATOM   4271 C  C   . LYS A 1 578 ? -4.606  -65.899 -23.318 0.36 26.09  ? 841  LYS A C   1 
ATOM   4272 O  O   . LYS A 1 578 ? -4.767  -65.610 -22.122 0.36 25.90  ? 841  LYS A O   1 
ATOM   4273 C  CB  . LYS A 1 578 ? -5.482  -68.151 -24.030 0.36 27.98  ? 841  LYS A CB  1 
ATOM   4274 C  CG  . LYS A 1 578 ? -6.713  -69.024 -24.236 0.36 28.11  ? 841  LYS A CG  1 
ATOM   4275 C  CD  . LYS A 1 578 ? -6.427  -70.513 -24.095 0.36 28.68  ? 841  LYS A CD  1 
ATOM   4276 C  CE  . LYS A 1 578 ? -5.524  -71.071 -25.176 0.36 28.51  ? 841  LYS A CE  1 
ATOM   4277 N  NZ  . LYS A 1 578 ? -6.120  -70.921 -26.525 0.36 28.22  ? 841  LYS A NZ  1 
ATOM   4278 N  N   . ARG A 1 579 ? -3.503  -65.606 -24.011 0.36 25.97  ? 842  ARG A N   1 
ATOM   4279 C  CA  . ARG A 1 579 ? -2.339  -64.878 -23.438 0.36 26.33  ? 842  ARG A CA  1 
ATOM   4280 C  C   . ARG A 1 579 ? -2.647  -63.376 -23.441 0.36 26.61  ? 842  ARG A C   1 
ATOM   4281 O  O   . ARG A 1 579 ? -2.299  -62.702 -22.446 0.36 26.63  ? 842  ARG A O   1 
ATOM   4282 C  CB  . ARG A 1 579 ? -1.055  -65.216 -24.206 0.36 25.48  ? 842  ARG A CB  1 
ATOM   4283 C  CG  . ARG A 1 579 ? 0.220   -64.834 -23.468 0.36 25.57  ? 842  ARG A CG  1 
ATOM   4284 C  CD  . ARG A 1 579 ? 1.462   -65.579 -23.942 0.36 25.88  ? 842  ARG A CD  1 
ATOM   4285 N  NE  . ARG A 1 579 ? 1.233   -67.017 -23.922 0.36 25.26  ? 842  ARG A NE  1 
ATOM   4286 C  CZ  . ARG A 1 579 ? 1.176   -67.765 -22.827 0.36 25.13  ? 842  ARG A CZ  1 
ATOM   4287 N  NH1 . ARG A 1 579 ? 0.927   -69.060 -22.929 0.36 26.05  ? 842  ARG A NH1 1 
ATOM   4288 N  NH2 . ARG A 1 579 ? 1.377   -67.231 -21.636 0.36 25.97  ? 842  ARG A NH2 1 
ATOM   4289 N  N   . GLU A 1 580 ? -3.292  -62.879 -24.503 0.36 27.71  ? 843  GLU A N   1 
ATOM   4290 C  CA  . GLU A 1 580 ? -3.698  -61.450 -24.628 0.36 29.23  ? 843  GLU A CA  1 
ATOM   4291 C  C   . GLU A 1 580 ? -4.707  -61.088 -23.527 0.36 27.76  ? 843  GLU A C   1 
ATOM   4292 O  O   . GLU A 1 580 ? -4.811  -59.891 -23.217 0.36 26.49  ? 843  GLU A O   1 
ATOM   4293 C  CB  . GLU A 1 580 ? -4.265  -61.150 -26.020 0.36 31.00  ? 843  GLU A CB  1 
ATOM   4294 C  CG  . GLU A 1 580 ? -3.204  -61.063 -27.108 0.36 33.12  ? 843  GLU A CG  1 
ATOM   4295 C  CD  . GLU A 1 580 ? -3.717  -60.645 -28.482 0.36 35.47  ? 843  GLU A CD  1 
ATOM   4296 O  OE1 . GLU A 1 580 ? -4.960  -60.620 -28.673 0.36 37.95  ? 843  GLU A OE1 1 
ATOM   4297 O  OE2 . GLU A 1 580 ? -2.878  -60.346 -29.364 0.36 34.63  ? 843  GLU A OE2 1 
ATOM   4298 N  N   . ASP A 1 581 ? -5.396  -62.074 -22.939 0.36 27.92  ? 844  ASP A N   1 
ATOM   4299 C  CA  . ASP A 1 581 ? -6.421  -61.855 -21.881 0.36 28.37  ? 844  ASP A CA  1 
ATOM   4300 C  C   . ASP A 1 581 ? -5.716  -61.644 -20.534 0.36 28.56  ? 844  ASP A C   1 
ATOM   4301 O  O   . ASP A 1 581 ? -6.069  -60.662 -19.841 0.36 28.35  ? 844  ASP A O   1 
ATOM   4302 C  CB  . ASP A 1 581 ? -7.442  -62.998 -21.844 0.36 28.33  ? 844  ASP A CB  1 
ATOM   4303 C  CG  . ASP A 1 581 ? -8.879  -62.565 -21.571 0.36 28.58  ? 844  ASP A CG  1 
ATOM   4304 O  OD1 . ASP A 1 581 ? -9.080  -61.588 -20.816 0.36 27.47  ? 844  ASP A OD1 1 
ATOM   4305 O  OD2 . ASP A 1 581 ? -9.795  -63.214 -22.123 0.36 28.65  ? 844  ASP A OD2 1 
ATOM   4306 N  N   . GLN A 1 582 ? -4.762  -62.521 -20.196 0.36 28.45  ? 845  GLN A N   1 
ATOM   4307 C  CA  . GLN A 1 582 ? -3.999  -62.394 -18.921 0.36 28.54  ? 845  GLN A CA  1 
ATOM   4308 C  C   . GLN A 1 582 ? -3.255  -61.054 -18.929 0.36 27.47  ? 845  GLN A C   1 
ATOM   4309 O  O   . GLN A 1 582 ? -3.311  -60.369 -17.897 0.36 26.93  ? 845  GLN A O   1 
ATOM   4310 C  CB  . GLN A 1 582 ? -3.037  -63.576 -18.765 0.36 29.50  ? 845  GLN A CB  1 
ATOM   4311 C  CG  . GLN A 1 582 ? -3.697  -64.945 -18.796 0.36 29.95  ? 845  GLN A CG  1 
ATOM   4312 C  CD  . GLN A 1 582 ? -2.664  -66.037 -18.652 0.36 31.06  ? 845  GLN A CD  1 
ATOM   4313 O  OE1 . GLN A 1 582 ? -2.967  -67.162 -18.265 0.36 30.73  ? 845  GLN A OE1 1 
ATOM   4314 N  NE2 . GLN A 1 582 ? -1.418  -65.704 -18.948 0.36 30.67  ? 845  GLN A NE2 1 
ATOM   4315 N  N   . TRP A 1 583 ? -2.570  -60.715 -20.024 0.36 26.35  ? 846  TRP A N   1 
ATOM   4316 C  CA  . TRP A 1 583 ? -1.886  -59.407 -20.216 0.36 25.87  ? 846  TRP A CA  1 
ATOM   4317 C  C   . TRP A 1 583 ? -2.815  -58.257 -19.797 0.36 26.99  ? 846  TRP A C   1 
ATOM   4318 O  O   . TRP A 1 583 ? -2.313  -57.299 -19.174 0.36 26.82  ? 846  TRP A O   1 
ATOM   4319 C  CB  . TRP A 1 583 ? -1.393  -59.256 -21.662 0.36 25.12  ? 846  TRP A CB  1 
ATOM   4320 C  CG  . TRP A 1 583 ? -0.195  -60.100 -21.983 0.36 24.76  ? 846  TRP A CG  1 
ATOM   4321 C  CD1 . TRP A 1 583 ? 0.730   -60.578 -21.101 0.36 24.90  ? 846  TRP A CD1 1 
ATOM   4322 C  CD2 . TRP A 1 583 ? 0.225   -60.554 -23.282 0.36 24.28  ? 846  TRP A CD2 1 
ATOM   4323 N  NE1 . TRP A 1 583 ? 1.687   -61.304 -21.757 0.36 25.59  ? 846  TRP A NE1 1 
ATOM   4324 C  CE2 . TRP A 1 583 ? 1.402   -61.309 -23.097 0.36 25.01  ? 846  TRP A CE2 1 
ATOM   4325 C  CE3 . TRP A 1 583 ? -0.273  -60.401 -24.579 0.36 24.51  ? 846  TRP A CE3 1 
ATOM   4326 C  CZ2 . TRP A 1 583 ? 2.081   -61.905 -24.160 0.36 24.81  ? 846  TRP A CZ2 1 
ATOM   4327 C  CZ3 . TRP A 1 583 ? 0.396   -60.991 -25.630 0.36 24.67  ? 846  TRP A CZ3 1 
ATOM   4328 C  CH2 . TRP A 1 583 ? 1.559   -61.731 -25.421 0.36 24.72  ? 846  TRP A CH2 1 
ATOM   4329 N  N   . CYS A 1 584 ? -4.119  -58.348 -20.100 1.00 27.43  ? 847  CYS A N   1 
ATOM   4330 C  CA  . CYS A 1 584 ? -5.077  -57.265 -19.767 1.00 26.97  ? 847  CYS A CA  1 
ATOM   4331 C  C   . CYS A 1 584 ? -5.846  -57.583 -18.489 1.00 27.20  ? 847  CYS A C   1 
ATOM   4332 O  O   . CYS A 1 584 ? -6.888  -56.918 -18.263 1.00 28.59  ? 847  CYS A O   1 
ATOM   4333 C  CB  . CYS A 1 584 ? -5.975  -56.975 -20.949 1.00 29.42  ? 847  CYS A CB  1 
ATOM   4334 S  SG  . CYS A 1 584 ? -5.018  -56.275 -22.300 1.00 30.37  ? 847  CYS A SG  1 
ATOM   4335 N  N   . GLY A 1 585 ? -5.368  -58.550 -17.694 1.00 28.57  ? 848  GLY A N   1 
ATOM   4336 C  CA  . GLY A 1 585 ? -5.765  -58.725 -16.280 1.00 26.69  ? 848  GLY A CA  1 
ATOM   4337 C  C   . GLY A 1 585 ? -6.634  -59.939 -16.007 1.00 24.63  ? 848  GLY A C   1 
ATOM   4338 O  O   . GLY A 1 585 ? -7.060  -60.093 -14.853 1.00 28.51  ? 848  GLY A O   1 
ATOM   4339 N  N   . SER A 1 586 ? -6.925  -60.785 -16.994 1.00 24.05  ? 849  SER A N   1 
ATOM   4340 C  CA  . SER A 1 586 ? -7.774  -61.986 -16.778 1.00 26.54  ? 849  SER A CA  1 
ATOM   4341 C  C   . SER A 1 586 ? -7.179  -62.877 -15.687 1.00 29.90  ? 849  SER A C   1 
ATOM   4342 O  O   . SER A 1 586 ? -5.927  -62.980 -15.598 1.00 27.85  ? 849  SER A O   1 
ATOM   4343 C  CB  . SER A 1 586 ? -7.907  -62.781 -18.031 1.00 27.14  ? 849  SER A CB  1 
ATOM   4344 O  OG  . SER A 1 586 ? -8.703  -63.930 -17.797 1.00 27.57  ? 849  SER A OG  1 
ATOM   4345 N  N   . LEU A 1 587 ? -8.051  -63.563 -14.938 0.36 28.39  ? 850  LEU A N   1 
ATOM   4346 C  CA  . LEU A 1 587 ? -7.675  -64.522 -13.863 0.36 27.98  ? 850  LEU A CA  1 
ATOM   4347 C  C   . LEU A 1 587 ? -7.731  -65.968 -14.378 0.36 27.32  ? 850  LEU A C   1 
ATOM   4348 O  O   . LEU A 1 587 ? -7.622  -66.872 -13.534 0.36 27.50  ? 850  LEU A O   1 
ATOM   4349 C  CB  . LEU A 1 587 ? -8.620  -64.350 -12.667 0.36 27.91  ? 850  LEU A CB  1 
ATOM   4350 C  CG  . LEU A 1 587 ? -8.617  -62.981 -11.989 0.36 28.76  ? 850  LEU A CG  1 
ATOM   4351 C  CD1 . LEU A 1 587 ? -9.258  -63.073 -10.611 0.36 28.60  ? 850  LEU A CD1 1 
ATOM   4352 C  CD2 . LEU A 1 587 ? -7.208  -62.413 -11.880 0.36 29.46  ? 850  LEU A CD2 1 
ATOM   4353 N  N   . ILE A 1 588 ? -7.779  -66.152 -15.700 0.36 26.90  ? 851  ILE A N   1 
ATOM   4354 C  CA  . ILE A 1 588 ? -7.762  -67.516 -16.309 0.36 28.26  ? 851  ILE A CA  1 
ATOM   4355 C  C   . ILE A 1 588 ? -6.413  -68.185 -16.034 0.36 29.05  ? 851  ILE A C   1 
ATOM   4356 O  O   . ILE A 1 588 ? -5.401  -67.464 -15.984 0.36 28.22  ? 851  ILE A O   1 
ATOM   4357 C  CB  . ILE A 1 588 ? -8.078  -67.468 -17.821 0.36 27.90  ? 851  ILE A CB  1 
ATOM   4358 C  CG1 . ILE A 1 588 ? -7.100  -66.571 -18.583 0.36 28.00  ? 851  ILE A CG1 1 
ATOM   4359 C  CG2 . ILE A 1 588 ? -9.525  -67.066 -18.058 0.36 27.35  ? 851  ILE A CG2 1 
ATOM   4360 C  CD1 . ILE A 1 588 ? -7.292  -66.591 -20.081 0.36 27.71  ? 851  ILE A CD1 1 
ATOM   4361 N  N   . GLY A 1 589 ? -6.407  -69.512 -15.897 0.36 31.09  ? 852  GLY A N   1 
ATOM   4362 C  CA  . GLY A 1 589 ? -5.194  -70.276 -15.546 0.36 31.31  ? 852  GLY A CA  1 
ATOM   4363 C  C   . GLY A 1 589 ? -4.916  -70.265 -14.052 0.36 32.24  ? 852  GLY A C   1 
ATOM   4364 O  O   . GLY A 1 589 ? -3.882  -70.832 -13.665 0.36 32.46  ? 852  GLY A O   1 
ATOM   4365 N  N   . LEU A 1 590 ? -5.790  -69.636 -13.249 0.36 32.97  ? 853  LEU A N   1 
ATOM   4366 C  CA  . LEU A 1 590 ? -5.756  -69.669 -11.760 0.36 33.13  ? 853  LEU A CA  1 
ATOM   4367 C  C   . LEU A 1 590 ? -6.868  -70.597 -11.260 0.36 35.12  ? 853  LEU A C   1 
ATOM   4368 O  O   . LEU A 1 590 ? -7.958  -70.620 -11.883 0.36 34.97  ? 853  LEU A O   1 
ATOM   4369 C  CB  . LEU A 1 590 ? -5.933  -68.256 -11.192 0.36 32.87  ? 853  LEU A CB  1 
ATOM   4370 C  CG  . LEU A 1 590 ? -4.963  -67.195 -11.712 0.36 33.85  ? 853  LEU A CG  1 
ATOM   4371 C  CD1 . LEU A 1 590 ? -5.354  -65.811 -11.218 0.36 33.85  ? 853  LEU A CD1 1 
ATOM   4372 C  CD2 . LEU A 1 590 ? -3.529  -67.515 -11.313 0.36 33.51  ? 853  LEU A CD2 1 
ATOM   4373 N  N   . THR A 1 591 ? -6.597  -71.327 -10.174 0.36 36.46  ? 854  THR A N   1 
ATOM   4374 C  CA  . THR A 1 591 ? -7.517  -72.322 -9.561  0.36 36.53  ? 854  THR A CA  1 
ATOM   4375 C  C   . THR A 1 591 ? -8.765  -71.603 -9.036  0.36 35.30  ? 854  THR A C   1 
ATOM   4376 O  O   . THR A 1 591 ? -9.870  -72.098 -9.320  0.36 35.41  ? 854  THR A O   1 
ATOM   4377 C  CB  . THR A 1 591 ? -6.804  -73.158 -8.488  0.36 36.30  ? 854  THR A CB  1 
ATOM   4378 O  OG1 . THR A 1 591 ? -6.215  -72.288 -7.521  0.36 36.50  ? 854  THR A OG1 1 
ATOM   4379 C  CG2 . THR A 1 591 ? -5.733  -74.049 -9.072  0.36 37.25  ? 854  THR A CG2 1 
ATOM   4380 N  N   . SER A 1 592 ? -8.596  -70.483 -8.319  0.36 34.92  ? 855  SER A N   1 
ATOM   4381 C  CA  . SER A 1 592 ? -9.700  -69.630 -7.793  0.36 35.26  ? 855  SER A CA  1 
ATOM   4382 C  C   . SER A 1 592 ? -10.752 -69.407 -8.887  0.36 35.00  ? 855  SER A C   1 
ATOM   4383 O  O   . SER A 1 592 ? -11.917 -69.798 -8.687  0.36 37.54  ? 855  SER A O   1 
ATOM   4384 C  CB  . SER A 1 592 ? -9.184  -68.315 -7.268  0.36 34.98  ? 855  SER A CB  1 
ATOM   4385 O  OG  . SER A 1 592 ? -8.471  -67.609 -8.277  0.36 36.39  ? 855  SER A OG  1 
ATOM   4386 N  N   . ARG A 1 593 ? -10.340 -68.805 -10.004 0.36 34.50  ? 856  ARG A N   1 
ATOM   4387 C  CA  . ARG A 1 593 ? -11.219 -68.471 -11.154 0.36 34.35  ? 856  ARG A CA  1 
ATOM   4388 C  C   . ARG A 1 593 ? -11.881 -69.756 -11.669 0.36 34.58  ? 856  ARG A C   1 
ATOM   4389 O  O   . ARG A 1 593 ? -13.057 -69.684 -12.074 0.36 33.56  ? 856  ARG A O   1 
ATOM   4390 C  CB  . ARG A 1 593 ? -10.411 -67.757 -12.244 0.36 33.94  ? 856  ARG A CB  1 
ATOM   4391 C  CG  . ARG A 1 593 ? -11.251 -67.136 -13.351 0.36 34.05  ? 856  ARG A CG  1 
ATOM   4392 C  CD  . ARG A 1 593 ? -11.515 -68.072 -14.516 0.36 33.74  ? 856  ARG A CD  1 
ATOM   4393 N  NE  . ARG A 1 593 ? -12.101 -67.347 -15.633 0.36 34.99  ? 856  ARG A NE  1 
ATOM   4394 C  CZ  . ARG A 1 593 ? -12.897 -67.867 -16.565 0.36 34.52  ? 856  ARG A CZ  1 
ATOM   4395 N  NH1 . ARG A 1 593 ? -13.221 -69.149 -16.540 0.36 34.46  ? 856  ARG A NH1 1 
ATOM   4396 N  NH2 . ARG A 1 593 ? -13.367 -67.092 -17.528 0.36 33.68  ? 856  ARG A NH2 1 
ATOM   4397 N  N   . ALA A 1 594 ? -11.158 -70.881 -11.657 1.00 33.03  ? 857  ALA A N   1 
ATOM   4398 C  CA  . ALA A 1 594 ? -11.695 -72.191 -12.087 1.00 34.39  ? 857  ALA A CA  1 
ATOM   4399 C  C   . ALA A 1 594 ? -12.833 -72.655 -11.154 1.00 35.03  ? 857  ALA A C   1 
ATOM   4400 O  O   . ALA A 1 594 ? -13.832 -73.219 -11.646 1.00 31.58  ? 857  ALA A O   1 
ATOM   4401 C  CB  . ALA A 1 594 ? -10.577 -73.218 -12.112 1.00 38.73  ? 857  ALA A CB  1 
ATOM   4402 N  N   . THR A 1 595 ? -12.685 -72.461 -9.851  1.00 33.48  ? 858  THR A N   1 
ATOM   4403 C  CA  . THR A 1 595 ? -13.711 -72.847 -8.868  1.00 38.43  ? 858  THR A CA  1 
ATOM   4404 C  C   . THR A 1 595 ? -14.949 -71.968 -9.088  1.00 40.03  ? 858  THR A C   1 
ATOM   4405 O  O   . THR A 1 595 ? -16.079 -72.501 -9.135  1.00 40.21  ? 858  THR A O   1 
ATOM   4406 C  CB  . THR A 1 595 ? -13.186 -72.735 -7.438  1.00 38.13  ? 858  THR A CB  1 
ATOM   4407 O  OG1 . THR A 1 595 ? -11.966 -73.475 -7.359  1.00 49.21  ? 858  THR A OG1 1 
ATOM   4408 C  CG2 . THR A 1 595 ? -14.195 -73.289 -6.461  1.00 38.07  ? 858  THR A CG2 1 
ATOM   4409 N  N   . TRP A 1 596 ? -14.727 -70.667 -9.253  1.00 37.73  ? 859  TRP A N   1 
ATOM   4410 C  CA  . TRP A 1 596 ? -15.797 -69.666 -9.497  1.00 33.58  ? 859  TRP A CA  1 
ATOM   4411 C  C   . TRP A 1 596 ? -16.593 -70.066 -10.744 1.00 32.07  ? 859  TRP A C   1 
ATOM   4412 O  O   . TRP A 1 596 ? -17.832 -70.201 -10.639 1.00 32.64  ? 859  TRP A O   1 
ATOM   4413 C  CB  . TRP A 1 596 ? -15.171 -68.266 -9.601  1.00 32.10  ? 859  TRP A CB  1 
ATOM   4414 C  CG  . TRP A 1 596 ? -16.040 -67.177 -10.134 1.00 29.69  ? 859  TRP A CG  1 
ATOM   4415 C  CD1 . TRP A 1 596 ? -17.063 -66.559 -9.485  1.00 29.65  ? 859  TRP A CD1 1 
ATOM   4416 C  CD2 . TRP A 1 596 ? -15.893 -66.499 -11.390 1.00 31.25  ? 859  TRP A CD2 1 
ATOM   4417 N  NE1 . TRP A 1 596 ? -17.555 -65.535 -10.243 1.00 29.31  ? 859  TRP A NE1 1 
ATOM   4418 C  CE2 . TRP A 1 596 ? -16.871 -65.480 -11.424 1.00 29.16  ? 859  TRP A CE2 1 
ATOM   4419 C  CE3 . TRP A 1 596 ? -15.011 -66.636 -12.469 1.00 31.69  ? 859  TRP A CE3 1 
ATOM   4420 C  CZ2 . TRP A 1 596 ? -17.011 -64.611 -12.501 1.00 27.06  ? 859  TRP A CZ2 1 
ATOM   4421 C  CZ3 . TRP A 1 596 ? -15.122 -65.760 -13.530 1.00 32.34  ? 859  TRP A CZ3 1 
ATOM   4422 C  CH2 . TRP A 1 596 ? -16.134 -64.775 -13.549 1.00 34.92  ? 859  TRP A CH2 1 
ATOM   4423 N  N   . ALA A 1 597 ? -15.920 -70.256 -11.877 1.00 31.85  ? 860  ALA A N   1 
ATOM   4424 C  CA  . ALA A 1 597 ? -16.558 -70.666 -13.152 1.00 38.68  ? 860  ALA A CA  1 
ATOM   4425 C  C   . ALA A 1 597 ? -17.395 -71.951 -12.978 1.00 39.38  ? 860  ALA A C   1 
ATOM   4426 O  O   . ALA A 1 597 ? -18.593 -71.960 -13.314 1.00 40.88  ? 860  ALA A O   1 
ATOM   4427 C  CB  . ALA A 1 597 ? -15.508 -70.834 -14.218 1.00 34.25  ? 860  ALA A CB  1 
ATOM   4428 N  N   . LYS A 1 598 ? -16.777 -73.013 -12.448 0.36 38.66  ? 861  LYS A N   1 
ATOM   4429 C  CA  . LYS A 1 598 ? -17.417 -74.348 -12.283 0.36 38.81  ? 861  LYS A CA  1 
ATOM   4430 C  C   . LYS A 1 598 ? -18.639 -74.227 -11.366 0.36 35.91  ? 861  LYS A C   1 
ATOM   4431 O  O   . LYS A 1 598 ? -19.678 -74.812 -11.714 0.36 35.34  ? 861  LYS A O   1 
ATOM   4432 C  CB  . LYS A 1 598 ? -16.435 -75.387 -11.727 0.36 42.35  ? 861  LYS A CB  1 
ATOM   4433 C  CG  . LYS A 1 598 ? -17.079 -76.682 -11.236 0.36 44.25  ? 861  LYS A CG  1 
ATOM   4434 C  CD  . LYS A 1 598 ? -16.123 -77.848 -11.076 0.36 46.61  ? 861  LYS A CD  1 
ATOM   4435 C  CE  . LYS A 1 598 ? -16.214 -78.857 -12.205 0.36 47.46  ? 861  LYS A CE  1 
ATOM   4436 N  NZ  . LYS A 1 598 ? -17.476 -79.636 -12.152 0.36 46.19  ? 861  LYS A NZ  1 
ATOM   4437 N  N   . ASN A 1 599 ? -18.512 -73.504 -10.249 0.36 33.07  ? 862  ASN A N   1 
ATOM   4438 C  CA  . ASN A 1 599 ? -19.563 -73.357 -9.204  0.36 32.72  ? 862  ASN A CA  1 
ATOM   4439 C  C   . ASN A 1 599 ? -20.327 -72.037 -9.394  0.36 31.40  ? 862  ASN A C   1 
ATOM   4440 O  O   . ASN A 1 599 ? -20.655 -71.401 -8.376  0.36 30.74  ? 862  ASN A O   1 
ATOM   4441 C  CB  . ASN A 1 599 ? -18.961 -73.416 -7.794  0.36 31.61  ? 862  ASN A CB  1 
ATOM   4442 C  CG  . ASN A 1 599 ? -18.140 -74.663 -7.535  0.36 31.93  ? 862  ASN A CG  1 
ATOM   4443 O  OD1 . ASN A 1 599 ? -18.148 -75.594 -8.335  0.36 31.84  ? 862  ASN A OD1 1 
ATOM   4444 N  ND2 . ASN A 1 599 ? -17.433 -74.692 -6.415  0.36 30.88  ? 862  ASN A ND2 1 
ATOM   4445 N  N   . ILE A 1 600 ? -20.605 -71.635 -10.637 0.36 31.62  ? 863  ILE A N   1 
ATOM   4446 C  CA  . ILE A 1 600 ? -21.220 -70.307 -10.954 0.36 32.45  ? 863  ILE A CA  1 
ATOM   4447 C  C   . ILE A 1 600 ? -22.714 -70.339 -10.596 0.36 33.44  ? 863  ILE A C   1 
ATOM   4448 O  O   . ILE A 1 600 ? -23.206 -69.328 -10.055 0.36 32.80  ? 863  ILE A O   1 
ATOM   4449 C  CB  . ILE A 1 600 ? -20.973 -69.896 -12.423 0.36 32.14  ? 863  ILE A CB  1 
ATOM   4450 C  CG1 . ILE A 1 600 ? -21.285 -68.414 -12.659 0.36 33.48  ? 863  ILE A CG1 1 
ATOM   4451 C  CG2 . ILE A 1 600 ? -21.737 -70.783 -13.393 0.36 32.54  ? 863  ILE A CG2 1 
ATOM   4452 C  CD1 . ILE A 1 600 ? -20.377 -67.458 -11.912 0.36 32.67  ? 863  ILE A CD1 1 
ATOM   4453 N  N   A GLN A 1 601 ? -23.394 -71.463 -10.857 0.18 33.77  ? 864  GLN A N   1 
ATOM   4454 N  N   B GLN A 1 601 ? -23.416 -71.446 -10.850 0.18 33.43  ? 864  GLN A N   1 
ATOM   4455 C  CA  A GLN A 1 601 ? -24.851 -71.640 -10.599 0.18 35.16  ? 864  GLN A CA  1 
ATOM   4456 C  CA  B GLN A 1 601 ? -24.879 -71.567 -10.594 0.18 34.63  ? 864  GLN A CA  1 
ATOM   4457 C  C   A GLN A 1 601 ? -25.141 -71.492 -9.098  0.18 33.78  ? 864  GLN A C   1 
ATOM   4458 C  C   B GLN A 1 601 ? -25.153 -71.482 -9.084  0.18 33.52  ? 864  GLN A C   1 
ATOM   4459 O  O   A GLN A 1 601 ? -26.226 -71.003 -8.765  0.18 34.06  ? 864  GLN A O   1 
ATOM   4460 O  O   B GLN A 1 601 ? -26.244 -71.022 -8.727  0.18 33.84  ? 864  GLN A O   1 
ATOM   4461 C  CB  A GLN A 1 601 ? -25.342 -72.987 -11.136 0.18 36.15  ? 864  GLN A CB  1 
ATOM   4462 C  CB  B GLN A 1 601 ? -25.450 -72.847 -11.210 0.18 35.32  ? 864  GLN A CB  1 
ATOM   4463 C  CG  A GLN A 1 601 ? -25.363 -73.066 -12.660 0.18 36.56  ? 864  GLN A CG  1 
ATOM   4464 C  CG  B GLN A 1 601 ? -26.976 -72.907 -11.219 0.18 35.05  ? 864  GLN A CG  1 
ATOM   4465 C  CD  A GLN A 1 601 ? -26.373 -72.153 -13.313 0.18 36.53  ? 864  GLN A CD  1 
ATOM   4466 C  CD  B GLN A 1 601 ? -27.639 -71.772 -11.966 0.18 35.98  ? 864  GLN A CD  1 
ATOM   4467 O  OE1 A GLN A 1 601 ? -27.349 -71.723 -12.699 0.18 36.99  ? 864  GLN A OE1 1 
ATOM   4468 O  OE1 B GLN A 1 601 ? -27.183 -71.341 -13.023 0.18 36.39  ? 864  GLN A OE1 1 
ATOM   4469 N  NE2 A GLN A 1 601 ? -26.152 -71.861 -14.586 0.18 35.82  ? 864  GLN A NE2 1 
ATOM   4470 N  NE2 B GLN A 1 601 ? -28.747 -71.286 -11.427 0.18 36.07  ? 864  GLN A NE2 1 
ATOM   4471 N  N   . THR A 1 602 ? -24.201 -71.872 -8.232  1.00 33.10  ? 865  THR A N   1 
ATOM   4472 C  CA  . THR A 1 602 ? -24.340 -71.706 -6.761  1.00 34.45  ? 865  THR A CA  1 
ATOM   4473 C  C   . THR A 1 602 ? -24.287 -70.228 -6.356  1.00 35.66  ? 865  THR A C   1 
ATOM   4474 O  O   . THR A 1 602 ? -24.949 -69.856 -5.367  1.00 38.27  ? 865  THR A O   1 
ATOM   4475 C  CB  . THR A 1 602 ? -23.270 -72.502 -6.033  1.00 34.79  ? 865  THR A CB  1 
ATOM   4476 O  OG1 . THR A 1 602 ? -23.447 -73.831 -6.521  1.00 40.31  ? 865  THR A OG1 1 
ATOM   4477 C  CG2 . THR A 1 602 ? -23.406 -72.422 -4.537  1.00 37.73  ? 865  THR A CG2 1 
ATOM   4478 N  N   . ALA A 1 603 ? -23.515 -69.402 -7.053  1.00 35.31  ? 866  ALA A N   1 
ATOM   4479 C  CA  . ALA A 1 603 ? -23.417 -67.969 -6.727  1.00 33.47  ? 866  ALA A CA  1 
ATOM   4480 C  C   . ALA A 1 603 ? -24.690 -67.311 -7.216  1.00 29.49  ? 866  ALA A C   1 
ATOM   4481 O  O   . ALA A 1 603 ? -25.257 -66.523 -6.504  1.00 27.05  ? 866  ALA A O   1 
ATOM   4482 C  CB  . ALA A 1 603 ? -22.208 -67.340 -7.357  1.00 31.63  ? 866  ALA A CB  1 
ATOM   4483 N  N   . ILE A 1 604 ? -25.069 -67.618 -8.441  1.00 31.57  ? 867  ILE A N   1 
ATOM   4484 C  CA  . ILE A 1 604 ? -26.335 -67.139 -9.041  1.00 33.18  ? 867  ILE A CA  1 
ATOM   4485 C  C   . ILE A 1 604 ? -27.490 -67.446 -8.080  1.00 32.82  ? 867  ILE A C   1 
ATOM   4486 O  O   . ILE A 1 604 ? -28.265 -66.523 -7.779  1.00 34.66  ? 867  ILE A O   1 
ATOM   4487 C  CB  . ILE A 1 604 ? -26.529 -67.772 -10.424 1.00 34.40  ? 867  ILE A CB  1 
ATOM   4488 C  CG1 . ILE A 1 604 ? -25.487 -67.257 -11.420 1.00 32.47  ? 867  ILE A CG1 1 
ATOM   4489 C  CG2 . ILE A 1 604 ? -27.947 -67.507 -10.906 1.00 35.02  ? 867  ILE A CG2 1 
ATOM   4490 C  CD1 . ILE A 1 604 ? -25.546 -67.903 -12.789 1.00 36.70  ? 867  ILE A CD1 1 
ATOM   4491 N  N   . ASN A 1 605 ? -27.579 -68.679 -7.573  1.00 35.96  ? 868  ASN A N   1 
ATOM   4492 C  CA  . ASN A 1 605 ? -28.663 -69.101 -6.639  1.00 34.63  ? 868  ASN A CA  1 
ATOM   4493 C  C   . ASN A 1 605 ? -28.560 -68.324 -5.312  1.00 35.40  ? 868  ASN A C   1 
ATOM   4494 O  O   . ASN A 1 605 ? -29.611 -68.042 -4.719  1.00 31.84  ? 868  ASN A O   1 
ATOM   4495 C  CB  . ASN A 1 605 ? -28.675 -70.620 -6.442  1.00 38.62  ? 868  ASN A CB  1 
ATOM   4496 C  CG  . ASN A 1 605 ? -29.069 -71.406 -7.685  1.00 44.09  ? 868  ASN A CG  1 
ATOM   4497 O  OD1 . ASN A 1 605 ? -29.717 -70.911 -8.612  1.00 48.68  ? 868  ASN A OD1 1 
ATOM   4498 N  ND2 . ASN A 1 605 ? -28.645 -72.652 -7.734  1.00 48.03  ? 868  ASN A ND2 1 
ATOM   4499 N  N   . GLN A 1 606 ? -27.360 -67.988 -4.825  1.00 33.23  ? 869  GLN A N   1 
ATOM   4500 C  CA  . GLN A 1 606 ? -27.229 -67.209 -3.562  1.00 33.35  ? 869  GLN A CA  1 
ATOM   4501 C  C   . GLN A 1 606 ? -27.940 -65.853 -3.729  1.00 33.05  ? 869  GLN A C   1 
ATOM   4502 O  O   . GLN A 1 606 ? -28.653 -65.411 -2.817  1.00 38.16  ? 869  GLN A O   1 
ATOM   4503 C  CB  . GLN A 1 606 ? -25.773 -66.982 -3.154  1.00 33.52  ? 869  GLN A CB  1 
ATOM   4504 C  CG  . GLN A 1 606 ? -25.634 -66.310 -1.775  1.00 37.93  ? 869  GLN A CG  1 
ATOM   4505 C  CD  . GLN A 1 606 ? -24.213 -65.914 -1.400  1.00 43.99  ? 869  GLN A CD  1 
ATOM   4506 O  OE1 . GLN A 1 606 ? -23.338 -65.773 -2.259  1.00 43.73  ? 869  GLN A OE1 1 
ATOM   4507 N  NE2 . GLN A 1 606 ? -23.973 -65.735 -0.105  1.00 40.53  ? 869  GLN A NE2 1 
ATOM   4508 N  N   . VAL A 1 607 ? -27.703 -65.185 -4.848  1.00 30.26  ? 870  VAL A N   1 
ATOM   4509 C  CA  . VAL A 1 607 ? -28.260 -63.841 -5.122  1.00 30.37  ? 870  VAL A CA  1 
ATOM   4510 C  C   . VAL A 1 607 ? -29.778 -64.002 -5.399  1.00 28.41  ? 870  VAL A C   1 
ATOM   4511 O  O   . VAL A 1 607 ? -30.550 -63.204 -4.885  1.00 28.86  ? 870  VAL A O   1 
ATOM   4512 C  CB  . VAL A 1 607 ? -27.496 -63.183 -6.282  1.00 30.05  ? 870  VAL A CB  1 
ATOM   4513 C  CG1 . VAL A 1 607 ? -28.183 -61.905 -6.746  1.00 28.12  ? 870  VAL A CG1 1 
ATOM   4514 C  CG2 . VAL A 1 607 ? -26.030 -62.946 -5.911  1.00 31.24  ? 870  VAL A CG2 1 
ATOM   4515 N  N   . ARG A 1 608 ? -30.198 -65.002 -6.168  1.00 28.62  ? 871  ARG A N   1 
ATOM   4516 C  CA  . ARG A 1 608 ? -31.653 -65.239 -6.404  1.00 31.36  ? 871  ARG A CA  1 
ATOM   4517 C  C   . ARG A 1 608 ? -32.383 -65.390 -5.066  1.00 34.52  ? 871  ARG A C   1 
ATOM   4518 O  O   . ARG A 1 608 ? -33.455 -64.778 -4.914  1.00 39.58  ? 871  ARG A O   1 
ATOM   4519 C  CB  . ARG A 1 608 ? -31.859 -66.452 -7.302  1.00 30.35  ? 871  ARG A CB  1 
ATOM   4520 C  CG  . ARG A 1 608 ? -31.477 -66.173 -8.747  1.00 29.41  ? 871  ARG A CG  1 
ATOM   4521 C  CD  . ARG A 1 608 ? -31.749 -67.419 -9.552  1.00 30.45  ? 871  ARG A CD  1 
ATOM   4522 N  NE  . ARG A 1 608 ? -31.584 -67.145 -10.965 1.00 33.61  ? 871  ARG A NE  1 
ATOM   4523 C  CZ  . ARG A 1 608 ? -31.503 -68.070 -11.911 1.00 35.55  ? 871  ARG A CZ  1 
ATOM   4524 N  NH1 . ARG A 1 608 ? -31.579 -69.347 -11.589 1.00 41.79  ? 871  ARG A NH1 1 
ATOM   4525 N  NH2 . ARG A 1 608 ? -31.324 -67.722 -13.175 1.00 36.69  ? 871  ARG A NH2 1 
ATOM   4526 N  N   . SER A 1 609 ? -31.812 -66.119 -4.110  1.00 32.26  ? 872  SER A N   1 
ATOM   4527 C  CA  . SER A 1 609 ? -32.423 -66.312 -2.773  1.00 33.53  ? 872  SER A CA  1 
ATOM   4528 C  C   . SER A 1 609 ? -32.548 -64.998 -2.004  1.00 35.68  ? 872  SER A C   1 
ATOM   4529 O  O   . SER A 1 609 ? -33.489 -64.866 -1.237  1.00 34.90  ? 872  SER A O   1 
ATOM   4530 C  CB  . SER A 1 609 ? -31.678 -67.349 -1.998  1.00 33.44  ? 872  SER A CB  1 
ATOM   4531 O  OG  . SER A 1 609 ? -31.557 -68.508 -2.817  1.00 35.93  ? 872  SER A OG  1 
ATOM   4532 N  N   . LEU A 1 610 ? -31.625 -64.064 -2.172  1.00 36.39  ? 873  LEU A N   1 
ATOM   4533 C  CA  . LEU A 1 610 ? -31.636 -62.780 -1.421  1.00 34.11  ? 873  LEU A CA  1 
ATOM   4534 C  C   . LEU A 1 610 ? -32.709 -61.853 -1.997  1.00 33.78  ? 873  LEU A C   1 
ATOM   4535 O  O   . LEU A 1 610 ? -33.420 -61.203 -1.208  1.00 32.80  ? 873  LEU A O   1 
ATOM   4536 C  CB  . LEU A 1 610 ? -30.250 -62.139 -1.531  1.00 35.51  ? 873  LEU A CB  1 
ATOM   4537 C  CG  . LEU A 1 610 ? -29.153 -62.782 -0.699  1.00 35.06  ? 873  LEU A CG  1 
ATOM   4538 C  CD1 . LEU A 1 610 ? -27.796 -62.157 -1.023  1.00 37.52  ? 873  LEU A CD1 1 
ATOM   4539 C  CD2 . LEU A 1 610 ? -29.440 -62.652 0.793   1.00 36.75  ? 873  LEU A CD2 1 
ATOM   4540 N  N   . ILE A 1 611 ? -32.797 -61.794 -3.321  1.00 31.10  ? 874  ILE A N   1 
ATOM   4541 C  CA  . ILE A 1 611 ? -33.804 -60.985 -4.061  1.00 36.89  ? 874  ILE A CA  1 
ATOM   4542 C  C   . ILE A 1 611 ? -35.224 -61.564 -3.852  1.00 39.33  ? 874  ILE A C   1 
ATOM   4543 O  O   . ILE A 1 611 ? -36.165 -60.778 -3.619  1.00 39.05  ? 874  ILE A O   1 
ATOM   4544 C  CB  . ILE A 1 611 ? -33.410 -60.860 -5.545  1.00 35.65  ? 874  ILE A CB  1 
ATOM   4545 C  CG1 . ILE A 1 611 ? -32.105 -60.063 -5.681  1.00 34.48  ? 874  ILE A CG1 1 
ATOM   4546 C  CG2 . ILE A 1 611 ? -34.564 -60.222 -6.309  1.00 38.83  ? 874  ILE A CG2 1 
ATOM   4547 C  CD1 . ILE A 1 611 ? -31.554 -59.967 -7.077  1.00 35.50  ? 874  ILE A CD1 1 
ATOM   4548 N  N   . GLY A 1 612 ? -35.359 -62.892 -3.932  0.50 38.80  ? 875  GLY A N   1 
ATOM   4549 C  CA  . GLY A 1 612 ? -36.600 -63.631 -3.619  0.50 40.81  ? 875  GLY A CA  1 
ATOM   4550 C  C   . GLY A 1 612 ? -37.212 -64.306 -4.838  0.50 41.95  ? 875  GLY A C   1 
ATOM   4551 O  O   . GLY A 1 612 ? -36.505 -64.494 -5.847  0.50 39.75  ? 875  GLY A O   1 
ATOM   4552 N  N   . ASN A 1 613 ? -38.501 -64.650 -4.743  1.00 45.81  ? 876  ASN A N   1 
ATOM   4553 C  CA  . ASN A 1 613 ? -39.217 -65.471 -5.756  1.00 44.71  ? 876  ASN A CA  1 
ATOM   4554 C  C   . ASN A 1 613 ? -39.701 -64.565 -6.897  1.00 43.62  ? 876  ASN A C   1 
ATOM   4555 O  O   . ASN A 1 613 ? -40.767 -63.965 -6.779  1.00 56.77  ? 876  ASN A O   1 
ATOM   4556 C  CB  . ASN A 1 613 ? -40.343 -66.233 -5.052  1.00 52.98  ? 876  ASN A CB  1 
ATOM   4557 C  CG  . ASN A 1 613 ? -40.971 -67.294 -5.925  1.00 60.30  ? 876  ASN A CG  1 
ATOM   4558 O  OD1 . ASN A 1 613 ? -40.349 -67.763 -6.878  1.00 63.85  ? 876  ASN A OD1 1 
ATOM   4559 N  ND2 . ASN A 1 613 ? -42.190 -67.695 -5.590  1.00 63.45  ? 876  ASN A ND2 1 
ATOM   4560 N  N   . GLU A 1 614 ? -38.940 -64.507 -7.976  1.00 37.80  ? 877  GLU A N   1 
ATOM   4561 C  CA  . GLU A 1 614 ? -39.119 -63.571 -9.110  1.00 36.02  ? 877  GLU A CA  1 
ATOM   4562 C  C   . GLU A 1 614 ? -38.963 -64.432 -10.355 1.00 34.81  ? 877  GLU A C   1 
ATOM   4563 O  O   . GLU A 1 614 ? -38.694 -65.649 -10.161 1.00 32.81  ? 877  GLU A O   1 
ATOM   4564 C  CB  . GLU A 1 614 ? -38.107 -62.429 -9.035  1.00 35.01  ? 877  GLU A CB  1 
ATOM   4565 C  CG  . GLU A 1 614 ? -38.249 -61.552 -7.802  1.00 35.60  ? 877  GLU A CG  1 
ATOM   4566 C  CD  . GLU A 1 614 ? -39.369 -60.510 -7.831  1.00 37.62  ? 877  GLU A CD  1 
ATOM   4567 O  OE1 . GLU A 1 614 ? -39.964 -60.274 -8.921  1.00 33.53  ? 877  GLU A OE1 1 
ATOM   4568 O  OE2 . GLU A 1 614 ? -39.602 -59.875 -6.772  1.00 35.13  ? 877  GLU A OE2 1 
ATOM   4569 N  N   . GLU A 1 615 ? -39.206 -63.885 -11.545 1.00 39.09  ? 878  GLU A N   1 
ATOM   4570 C  CA  . GLU A 1 615 ? -38.957 -64.632 -12.810 1.00 45.34  ? 878  GLU A CA  1 
ATOM   4571 C  C   . GLU A 1 615 ? -37.515 -64.324 -13.225 1.00 43.78  ? 878  GLU A C   1 
ATOM   4572 O  O   . GLU A 1 615 ? -37.235 -63.137 -13.475 1.00 44.47  ? 878  GLU A O   1 
ATOM   4573 C  CB  . GLU A 1 615 ? -39.918 -64.268 -13.946 1.00 49.07  ? 878  GLU A CB  1 
ATOM   4574 C  CG  . GLU A 1 615 ? -39.684 -65.101 -15.213 1.00 58.26  ? 878  GLU A CG  1 
ATOM   4575 C  CD  . GLU A 1 615 ? -40.423 -64.641 -16.471 1.00 75.23  ? 878  GLU A CD  1 
ATOM   4576 O  OE1 . GLU A 1 615 ? -41.457 -63.919 -16.345 1.00 73.79  ? 878  GLU A OE1 1 
ATOM   4577 O  OE2 . GLU A 1 615 ? -39.974 -65.006 -17.590 1.00 84.92  ? 878  GLU A OE2 1 
ATOM   4578 N  N   . TYR A 1 616 ? -36.679 -65.366 -13.288 1.00 44.63  ? 879  TYR A N   1 
ATOM   4579 C  CA  . TYR A 1 616 ? -35.260 -65.365 -13.724 1.00 45.13  ? 879  TYR A CA  1 
ATOM   4580 C  C   . TYR A 1 616 ? -35.097 -66.168 -15.021 1.00 49.16  ? 879  TYR A C   1 
ATOM   4581 O  O   . TYR A 1 616 ? -35.875 -67.111 -15.269 1.00 44.78  ? 879  TYR A O   1 
ATOM   4582 C  CB  . TYR A 1 616 ? -34.382 -65.984 -12.636 1.00 41.91  ? 879  TYR A CB  1 
ATOM   4583 C  CG  . TYR A 1 616 ? -34.457 -65.293 -11.295 1.00 37.23  ? 879  TYR A CG  1 
ATOM   4584 C  CD1 . TYR A 1 616 ? -33.705 -64.155 -11.034 1.00 33.13  ? 879  TYR A CD1 1 
ATOM   4585 C  CD2 . TYR A 1 616 ? -35.234 -65.816 -10.266 1.00 34.43  ? 879  TYR A CD2 1 
ATOM   4586 C  CE1 . TYR A 1 616 ? -33.747 -63.537 -9.789  1.00 35.96  ? 879  TYR A CE1 1 
ATOM   4587 C  CE2 . TYR A 1 616 ? -35.300 -65.201 -9.027  1.00 32.60  ? 879  TYR A CE2 1 
ATOM   4588 C  CZ  . TYR A 1 616 ? -34.554 -64.060 -8.782  1.00 36.73  ? 879  TYR A CZ  1 
ATOM   4589 O  OH  . TYR A 1 616 ? -34.618 -63.440 -7.560  1.00 36.86  ? 879  TYR A OH  1 
ATOM   4590 N  N   . THR A 1 617 ? -34.090 -65.795 -15.816 1.00 46.99  ? 880  THR A N   1 
ATOM   4591 C  CA  . THR A 1 617 ? -33.578 -66.545 -16.991 1.00 46.16  ? 880  THR A CA  1 
ATOM   4592 C  C   . THR A 1 617 ? -32.153 -67.062 -16.706 1.00 47.82  ? 880  THR A C   1 
ATOM   4593 O  O   . THR A 1 617 ? -31.341 -66.316 -16.115 1.00 42.47  ? 880  THR A O   1 
ATOM   4594 C  CB  . THR A 1 617 ? -33.586 -65.613 -18.202 1.00 53.24  ? 880  THR A CB  1 
ATOM   4595 O  OG1 . THR A 1 617 ? -34.867 -64.989 -18.151 1.00 48.24  ? 880  THR A OG1 1 
ATOM   4596 C  CG2 . THR A 1 617 ? -33.333 -66.314 -19.520 1.00 51.60  ? 880  THR A CG2 1 
ATOM   4597 N  N   . ASP A 1 618 ? -31.847 -68.291 -17.131 1.00 47.86  ? 881  ASP A N   1 
ATOM   4598 C  CA  . ASP A 1 618 ? -30.471 -68.848 -17.129 1.00 46.19  ? 881  ASP A CA  1 
ATOM   4599 C  C   . ASP A 1 618 ? -29.788 -68.433 -18.442 1.00 45.39  ? 881  ASP A C   1 
ATOM   4600 O  O   . ASP A 1 618 ? -30.090 -69.019 -19.489 1.00 38.87  ? 881  ASP A O   1 
ATOM   4601 C  CB  . ASP A 1 618 ? -30.494 -70.362 -16.922 1.00 48.80  ? 881  ASP A CB  1 
ATOM   4602 C  CG  . ASP A 1 618 ? -29.120 -71.014 -16.796 1.00 59.36  ? 881  ASP A CG  1 
ATOM   4603 O  OD1 . ASP A 1 618 ? -28.110 -70.288 -16.498 1.00 48.67  ? 881  ASP A OD1 1 
ATOM   4604 O  OD2 . ASP A 1 618 ? -29.065 -72.259 -16.979 1.00 63.31  ? 881  ASP A OD2 1 
ATOM   4605 N  N   . TYR A 1 619 ? -28.856 -67.479 -18.387 1.00 40.45  ? 882  TYR A N   1 
ATOM   4606 C  CA  . TYR A 1 619 ? -28.046 -67.091 -19.563 1.00 38.78  ? 882  TYR A CA  1 
ATOM   4607 C  C   . TYR A 1 619 ? -26.757 -67.925 -19.670 1.00 37.74  ? 882  TYR A C   1 
ATOM   4608 O  O   . TYR A 1 619 ? -26.091 -67.826 -20.707 1.00 39.49  ? 882  TYR A O   1 
ATOM   4609 C  CB  . TYR A 1 619 ? -27.761 -65.600 -19.479 1.00 38.25  ? 882  TYR A CB  1 
ATOM   4610 C  CG  . TYR A 1 619 ? -28.991 -64.753 -19.637 1.00 41.06  ? 882  TYR A CG  1 
ATOM   4611 C  CD1 . TYR A 1 619 ? -29.556 -64.569 -20.886 1.00 41.08  ? 882  TYR A CD1 1 
ATOM   4612 C  CD2 . TYR A 1 619 ? -29.566 -64.118 -18.550 1.00 38.22  ? 882  TYR A CD2 1 
ATOM   4613 C  CE1 . TYR A 1 619 ? -30.674 -63.768 -21.053 1.00 43.12  ? 882  TYR A CE1 1 
ATOM   4614 C  CE2 . TYR A 1 619 ? -30.684 -63.313 -18.699 1.00 43.73  ? 882  TYR A CE2 1 
ATOM   4615 C  CZ  . TYR A 1 619 ? -31.236 -63.137 -19.956 1.00 43.58  ? 882  TYR A CZ  1 
ATOM   4616 O  OH  . TYR A 1 619 ? -32.325 -62.340 -20.120 1.00 40.92  ? 882  TYR A OH  1 
ATOM   4617 N  N   . MET A 1 620 ? -26.404 -68.732 -18.669 1.00 38.49  ? 883  MET A N   1 
ATOM   4618 C  CA  . MET A 1 620 ? -25.101 -69.466 -18.671 1.00 40.79  ? 883  MET A CA  1 
ATOM   4619 C  C   . MET A 1 620 ? -24.979 -70.436 -19.874 1.00 43.87  ? 883  MET A C   1 
ATOM   4620 O  O   . MET A 1 620 ? -23.886 -70.547 -20.435 1.00 51.59  ? 883  MET A O   1 
ATOM   4621 C  CB  . MET A 1 620 ? -24.834 -70.174 -17.333 1.00 36.42  ? 883  MET A CB  1 
ATOM   4622 C  CG  . MET A 1 620 ? -24.854 -69.264 -16.072 1.00 35.10  ? 883  MET A CG  1 
ATOM   4623 S  SD  . MET A 1 620 ? -24.049 -67.643 -16.319 1.00 40.26  ? 883  MET A SD  1 
ATOM   4624 C  CE  . MET A 1 620 ? -22.372 -68.197 -16.626 1.00 36.57  ? 883  MET A CE  1 
ATOM   4625 N  N   . PRO A 1 621 ? -26.036 -71.145 -20.362 1.00 49.77  ? 884  PRO A N   1 
ATOM   4626 C  CA  . PRO A 1 621 ? -25.919 -72.007 -21.552 1.00 47.59  ? 884  PRO A CA  1 
ATOM   4627 C  C   . PRO A 1 621 ? -25.637 -71.318 -22.899 1.00 48.66  ? 884  PRO A C   1 
ATOM   4628 O  O   . PRO A 1 621 ? -25.322 -72.032 -23.835 1.00 54.07  ? 884  PRO A O   1 
ATOM   4629 C  CB  . PRO A 1 621 ? -27.281 -72.744 -21.633 1.00 51.76  ? 884  PRO A CB  1 
ATOM   4630 C  CG  . PRO A 1 621 ? -27.863 -72.648 -20.224 1.00 49.26  ? 884  PRO A CG  1 
ATOM   4631 C  CD  . PRO A 1 621 ? -27.364 -71.300 -19.727 1.00 53.62  ? 884  PRO A CD  1 
ATOM   4632 N  N   . SER A 1 622 ? -25.676 -69.979 -22.965 1.00 48.54  ? 885  SER A N   1 
ATOM   4633 C  CA  . SER A 1 622 ? -25.183 -69.159 -24.109 1.00 50.39  ? 885  SER A CA  1 
ATOM   4634 C  C   . SER A 1 622 ? -23.657 -69.321 -24.275 1.00 54.40  ? 885  SER A C   1 
ATOM   4635 O  O   . SER A 1 622 ? -23.111 -68.863 -25.323 1.00 48.82  ? 885  SER A O   1 
ATOM   4636 C  CB  . SER A 1 622 ? -25.545 -67.692 -23.940 1.00 50.18  ? 885  SER A CB  1 
ATOM   4637 O  OG  . SER A 1 622 ? -24.672 -67.048 -23.023 1.00 44.98  ? 885  SER A OG  1 
ATOM   4638 N  N   . MET A 1 623 ? -22.988 -69.902 -23.270 1.00 46.99  ? 886  MET A N   1 
ATOM   4639 C  CA  . MET A 1 623 ? -21.531 -70.184 -23.289 1.00 58.44  ? 886  MET A CA  1 
ATOM   4640 C  C   . MET A 1 623 ? -21.321 -71.686 -23.476 1.00 59.71  ? 886  MET A C   1 
ATOM   4641 O  O   . MET A 1 623 ? -22.029 -72.461 -22.811 1.00 57.46  ? 886  MET A O   1 
ATOM   4642 C  CB  . MET A 1 623 ? -20.858 -69.764 -21.976 1.00 60.46  ? 886  MET A CB  1 
ATOM   4643 C  CG  . MET A 1 623 ? -21.332 -68.437 -21.439 1.00 63.46  ? 886  MET A CG  1 
ATOM   4644 S  SD  . MET A 1 623 ? -20.324 -67.900 -20.044 1.00 56.01  ? 886  MET A SD  1 
ATOM   4645 C  CE  . MET A 1 623 ? -18.958 -67.198 -20.962 1.00 54.20  ? 886  MET A CE  1 
ATOM   4646 N  N   . LYS A 1 624 ? -20.316 -72.043 -24.275 1.00 64.02  ? 887  LYS A N   1 
ATOM   4647 C  CA  . LYS A 1 624 ? -19.979 -73.426 -24.689 1.00 66.94  ? 887  LYS A CA  1 
ATOM   4648 C  C   . LYS A 1 624 ? -19.861 -74.381 -23.484 1.00 67.41  ? 887  LYS A C   1 
ATOM   4649 O  O   . LYS A 1 624 ? -20.438 -75.489 -23.525 1.00 63.66  ? 887  LYS A O   1 
ATOM   4650 C  CB  . LYS A 1 624 ? -18.667 -73.375 -25.480 1.00 76.20  ? 887  LYS A CB  1 
ATOM   4651 C  CG  . LYS A 1 624 ? -18.335 -74.618 -26.298 1.00 81.74  ? 887  LYS A CG  1 
ATOM   4652 C  CD  . LYS A 1 624 ? -17.578 -74.308 -27.590 1.00 84.30  ? 887  LYS A CD  1 
ATOM   4653 C  CE  . LYS A 1 624 ? -16.493 -75.318 -27.911 1.00 89.92  ? 887  LYS A CE  1 
ATOM   4654 N  NZ  . LYS A 1 624 ? -15.351 -75.220 -26.968 1.00 89.77  ? 887  LYS A NZ  1 
ATOM   4655 N  N   . ARG A 1 625 ? -19.133 -73.964 -22.442 0.36 66.05  ? 888  ARG A N   1 
ATOM   4656 C  CA  . ARG A 1 625 ? -18.768 -74.830 -21.285 0.36 65.78  ? 888  ARG A CA  1 
ATOM   4657 C  C   . ARG A 1 625 ? -20.011 -75.178 -20.452 0.36 64.04  ? 888  ARG A C   1 
ATOM   4658 O  O   . ARG A 1 625 ? -19.990 -76.241 -19.801 0.36 62.87  ? 888  ARG A O   1 
ATOM   4659 C  CB  . ARG A 1 625 ? -17.691 -74.167 -20.420 0.36 65.65  ? 888  ARG A CB  1 
ATOM   4660 C  CG  . ARG A 1 625 ? -18.139 -72.913 -19.681 0.36 65.53  ? 888  ARG A CG  1 
ATOM   4661 C  CD  . ARG A 1 625 ? -17.129 -72.529 -18.617 0.36 65.49  ? 888  ARG A CD  1 
ATOM   4662 N  NE  . ARG A 1 625 ? -17.096 -73.494 -17.521 0.36 65.54  ? 888  ARG A NE  1 
ATOM   4663 C  CZ  . ARG A 1 625 ? -16.070 -73.692 -16.693 0.36 65.69  ? 888  ARG A CZ  1 
ATOM   4664 N  NH1 . ARG A 1 625 ? -14.948 -73.000 -16.823 0.36 66.47  ? 888  ARG A NH1 1 
ATOM   4665 N  NH2 . ARG A 1 625 ? -16.168 -74.597 -15.734 0.36 63.91  ? 888  ARG A NH2 1 
ATOM   4666 N  N   . PHE A 1 626 ? -21.038 -74.318 -20.461 1.00 64.69  ? 889  PHE A N   1 
ATOM   4667 C  CA  . PHE A 1 626 ? -22.311 -74.535 -19.708 1.00 62.93  ? 889  PHE A CA  1 
ATOM   4668 C  C   . PHE A 1 626 ? -23.385 -75.127 -20.630 1.00 71.55  ? 889  PHE A C   1 
ATOM   4669 O  O   . PHE A 1 626 ? -24.486 -75.507 -20.157 1.00 67.52  ? 889  PHE A O   1 
ATOM   4670 C  CB  . PHE A 1 626 ? -22.791 -73.226 -19.081 1.00 60.86  ? 889  PHE A CB  1 
ATOM   4671 C  CG  . PHE A 1 626 ? -21.775 -72.600 -18.167 1.00 62.79  ? 889  PHE A CG  1 
ATOM   4672 C  CD1 . PHE A 1 626 ? -21.428 -73.217 -16.970 1.00 65.46  ? 889  PHE A CD1 1 
ATOM   4673 C  CD2 . PHE A 1 626 ? -21.130 -71.426 -18.526 1.00 59.08  ? 889  PHE A CD2 1 
ATOM   4674 C  CE1 . PHE A 1 626 ? -20.468 -72.660 -16.138 1.00 66.60  ? 889  PHE A CE1 1 
ATOM   4675 C  CE2 . PHE A 1 626 ? -20.179 -70.864 -17.691 1.00 64.02  ? 889  PHE A CE2 1 
ATOM   4676 C  CZ  . PHE A 1 626 ? -19.845 -71.482 -16.499 1.00 68.13  ? 889  PHE A CZ  1 
ATOM   4677 N  N   . ARG A 1 627 ? -23.099 -75.183 -21.930 1.00 84.73  ? 890  ARG A N   1 
ATOM   4678 C  CA  . ARG A 1 627 ? -23.964 -75.879 -22.912 1.00 100.05 ? 890  ARG A CA  1 
ATOM   4679 C  C   . ARG A 1 627 ? -23.783 -77.378 -22.631 1.00 110.85 ? 890  ARG A C   1 
ATOM   4680 O  O   . ARG A 1 627 ? -23.020 -78.035 -23.368 1.00 129.09 ? 890  ARG A O   1 
ATOM   4681 C  CB  . ARG A 1 627 ? -23.629 -75.405 -24.334 1.00 96.17  ? 890  ARG A CB  1 
ATOM   4682 C  CG  . ARG A 1 627 ? -24.842 -75.281 -25.243 1.00 96.39  ? 890  ARG A CG  1 
ATOM   4683 C  CD  . ARG A 1 627 ? -24.564 -74.506 -26.513 1.00 97.62  ? 890  ARG A CD  1 
ATOM   4684 N  NE  . ARG A 1 627 ? -23.201 -74.705 -26.988 1.00 98.47  ? 890  ARG A NE  1 
ATOM   4685 C  CZ  . ARG A 1 627 ? -22.749 -75.773 -27.647 1.00 97.72  ? 890  ARG A CZ  1 
ATOM   4686 N  NH1 . ARG A 1 627 ? -23.545 -76.793 -27.929 1.00 101.32 ? 890  ARG A NH1 1 
ATOM   4687 N  NH2 . ARG A 1 627 ? -21.482 -75.818 -28.024 1.00 89.03  ? 890  ARG A NH2 1 
ATOM   4688 N  N   . ARG A 1 628 ? -24.409 -77.860 -21.547 1.00 111.66 ? 891  ARG A N   1 
ATOM   4689 C  CA  . ARG A 1 628 ? -24.278 -79.238 -20.998 1.00 110.21 ? 891  ARG A CA  1 
ATOM   4690 C  C   . ARG A 1 628 ? -22.809 -79.501 -20.643 1.00 107.12 ? 891  ARG A C   1 
ATOM   4691 O  O   . ARG A 1 628 ? -21.957 -79.677 -21.516 1.00 100.18 ? 891  ARG A O   1 
ATOM   4692 C  CB  . ARG A 1 628 ? -24.844 -80.261 -21.993 1.00 112.17 ? 891  ARG A CB  1 
ATOM   4693 C  CG  . ARG A 1 628 ? -26.351 -80.163 -22.184 1.00 113.21 ? 891  ARG A CG  1 
ATOM   4694 C  CD  . ARG A 1 628 ? -27.145 -80.233 -20.889 1.00 114.11 ? 891  ARG A CD  1 
ATOM   4695 N  NE  . ARG A 1 628 ? -26.706 -81.301 -19.995 1.00 116.10 ? 891  ARG A NE  1 
ATOM   4696 C  CZ  . ARG A 1 628 ? -27.294 -81.624 -18.844 1.00 120.92 ? 891  ARG A CZ  1 
ATOM   4697 N  NH1 . ARG A 1 628 ? -28.367 -80.971 -18.426 1.00 129.87 ? 891  ARG A NH1 1 
ATOM   4698 N  NH2 . ARG A 1 628 ? -26.806 -82.610 -18.110 1.00 116.60 ? 891  ARG A NH2 1 
HETATM 4699 ZN ZN  . ZN  B 2 .   ? -6.508  -55.130 -23.708 1.00 28.27  2 1001 ZN  A ZN  1 
HETATM 4700 ZN ZN  . ZN  C 2 .   ? -25.917 -14.486 -12.981 1.00 62.48  2 1002 ZN  A ZN  1 
HETATM 4701 O  O1  A MES D 3 .   ? -28.475 -57.388 0.663   0.25 851.03 ? 1003 MES A O1  1 
HETATM 4702 O  O1  B MES D 3 .   ? -28.276 -57.243 0.639   0.25 33.53  ? 1003 MES A O1  1 
HETATM 4703 C  C2  A MES D 3 .   ? -27.771 -57.710 1.852   0.25 855.10 ? 1003 MES A C2  1 
HETATM 4704 C  C2  B MES D 3 .   ? -27.494 -57.838 1.665   0.25 32.90  ? 1003 MES A C2  1 
HETATM 4705 C  C3  A MES D 3 .   ? -26.331 -57.270 1.772   0.25 857.17 ? 1003 MES A C3  1 
HETATM 4706 C  C3  B MES D 3 .   ? -26.013 -57.739 1.375   0.25 32.03  ? 1003 MES A C3  1 
HETATM 4707 N  N4  A MES D 3 .   ? -25.657 -57.914 0.602   0.25 857.51 ? 1003 MES A N4  1 
HETATM 4708 N  N4  B MES D 3 .   ? -25.724 -58.416 0.076   0.25 30.51  ? 1003 MES A N4  1 
HETATM 4709 C  C5  A MES D 3 .   ? -26.452 -57.645 -0.637  0.25 853.11 ? 1003 MES A C5  1 
HETATM 4710 C  C5  B MES D 3 .   ? -26.513 -57.709 -0.974  0.25 32.06  ? 1003 MES A C5  1 
HETATM 4711 C  C6  A MES D 3 .   ? -27.887 -58.063 -0.438  0.25 848.32 ? 1003 MES A C6  1 
HETATM 4712 C  C6  B MES D 3 .   ? -27.983 -57.803 -0.636  0.25 32.02  ? 1003 MES A C6  1 
HETATM 4713 C  C7  A MES D 3 .   ? -24.239 -57.442 0.461   0.25 862.06 ? 1003 MES A C7  1 
HETATM 4714 C  C7  B MES D 3 .   ? -24.262 -58.513 -0.266  0.25 30.61  ? 1003 MES A C7  1 
HETATM 4715 C  C8  A MES D 3 .   ? -23.331 -58.457 -0.204  0.25 871.38 ? 1003 MES A C8  1 
HETATM 4716 C  C8  B MES D 3 .   ? -23.360 -57.559 0.493   0.25 29.78  ? 1003 MES A C8  1 
HETATM 4717 S  S   A MES D 3 .   ? -21.610 -58.022 -0.010  0.25 884.43 ? 1003 MES A S   1 
HETATM 4718 S  S   B MES D 3 .   ? -21.633 -58.016 0.389   0.25 30.23  ? 1003 MES A S   1 
HETATM 4719 O  O1S A MES D 3 .   ? -21.057 -58.928 0.920   0.25 888.40 ? 1003 MES A O1S 1 
HETATM 4720 O  O1S B MES D 3 .   ? -21.595 -59.451 0.302   0.25 30.53  ? 1003 MES A O1S 1 
HETATM 4721 O  O2S A MES D 3 .   ? -21.039 -58.212 -1.358  0.25 853.32 ? 1003 MES A O2S 1 
HETATM 4722 O  O2S B MES D 3 .   ? -21.125 -57.404 -0.808  0.25 29.24  ? 1003 MES A O2S 1 
HETATM 4723 O  O3S A MES D 3 .   ? -21.578 -56.657 0.375   0.25 888.11 ? 1003 MES A O3S 1 
HETATM 4724 O  O3S B MES D 3 .   ? -21.038 -57.510 1.586   0.25 27.56  ? 1003 MES A O3S 1 
HETATM 4725 S  S   . DMS E 4 .   ? -26.876 -61.886 -21.056 1.00 57.75  ? 1004 DMS A S   1 
HETATM 4726 O  O   . DMS E 4 .   ? -26.821 -62.521 -22.445 1.00 57.47  ? 1004 DMS A O   1 
HETATM 4727 C  C1  . DMS E 4 .   ? -28.140 -60.646 -21.154 1.00 53.81  ? 1004 DMS A C1  1 
HETATM 4728 C  C2  . DMS E 4 .   ? -25.457 -60.807 -20.966 1.00 55.02  ? 1004 DMS A C2  1 
HETATM 4729 S  S   . DMS F 4 .   ? -16.042 -69.457 -28.846 1.00 111.26 ? 1005 DMS A S   1 
HETATM 4730 O  O   . DMS F 4 .   ? -16.561 -68.043 -28.905 1.00 90.10  ? 1005 DMS A O   1 
HETATM 4731 C  C1  . DMS F 4 .   ? -16.943 -70.264 -27.545 1.00 104.10 ? 1005 DMS A C1  1 
HETATM 4732 C  C2  . DMS F 4 .   ? -14.453 -69.391 -28.052 1.00 105.35 ? 1005 DMS A C2  1 
HETATM 4733 P  P   . PO4 G 5 .   ? -4.091  -39.414 -23.815 1.00 70.60  ? 1006 PO4 A P   1 
HETATM 4734 O  O1  . PO4 G 5 .   ? -2.743  -40.068 -23.196 1.00 42.65  ? 1006 PO4 A O1  1 
HETATM 4735 O  O2  . PO4 G 5 .   ? -3.810  -37.937 -24.353 1.00 38.72  ? 1006 PO4 A O2  1 
HETATM 4736 O  O3  . PO4 G 5 .   ? -4.722  -40.256 -25.018 1.00 49.08  ? 1006 PO4 A O3  1 
HETATM 4737 O  O4  . PO4 G 5 .   ? -5.071  -39.433 -22.697 1.00 58.00  ? 1006 PO4 A O4  1 
HETATM 4738 P  P   . PO4 H 5 .   ? -17.986 -9.446  -28.535 1.00 110.98 ? 1007 PO4 A P   1 
HETATM 4739 O  O1  . PO4 H 5 .   ? -17.812 -9.908  -27.075 1.00 73.13  ? 1007 PO4 A O1  1 
HETATM 4740 O  O2  . PO4 H 5 .   ? -16.608 -9.135  -29.143 1.00 97.07  ? 1007 PO4 A O2  1 
HETATM 4741 O  O3  . PO4 H 5 .   ? -18.674 -10.558 -29.350 1.00 91.57  ? 1007 PO4 A O3  1 
HETATM 4742 O  O4  . PO4 H 5 .   ? -18.856 -8.171  -28.574 1.00 87.65  ? 1007 PO4 A O4  1 
HETATM 4743 C  C1  . PEG I 6 .   ? -16.455 -43.352 -41.101 1.00 69.51  ? 1008 PEG A C1  1 
HETATM 4744 O  O1  . PEG I 6 .   ? -17.834 -43.453 -40.771 1.00 65.75  ? 1008 PEG A O1  1 
HETATM 4745 C  C2  . PEG I 6 .   ? -16.151 -43.868 -42.474 1.00 72.22  ? 1008 PEG A C2  1 
HETATM 4746 O  O2  . PEG I 6 .   ? -16.085 -45.290 -42.435 1.00 74.68  ? 1008 PEG A O2  1 
HETATM 4747 C  C3  . PEG I 6 .   ? -16.259 -45.909 -43.706 1.00 78.67  ? 1008 PEG A C3  1 
HETATM 4748 C  C4  . PEG I 6 .   ? -15.135 -46.872 -43.959 1.00 84.45  ? 1008 PEG A C4  1 
HETATM 4749 O  O4  . PEG I 6 .   ? -15.589 -48.120 -44.449 1.00 82.45  ? 1008 PEG A O4  1 
HETATM 4750 CL CL  . CL  J 7 .   ? 4.239   -48.794 -29.763 1.00 45.20  ? 1009 CL  A CL  1 
HETATM 4751 N  N1  . UWS K 8 .   ? -7.628  -71.281 -20.828 0.36 76.03  ? 1010 UWS A N1  1 
HETATM 4752 C  C4  . UWS K 8 .   ? -5.625  -72.354 -20.154 0.36 75.96  ? 1010 UWS A C4  1 
HETATM 4753 C  C5  . UWS K 8 .   ? -8.834  -70.860 -20.586 0.36 75.38  ? 1010 UWS A C5  1 
HETATM 4754 C  C6  . UWS K 8 .   ? -9.539  -70.181 -21.717 0.36 74.67  ? 1010 UWS A C6  1 
HETATM 4755 C  C7  . UWS K 8 .   ? -9.462  -71.032 -19.320 0.36 76.51  ? 1010 UWS A C7  1 
HETATM 4756 C  C8  . UWS K 8 .   ? -8.782  -71.657 -18.342 0.36 76.58  ? 1010 UWS A C8  1 
HETATM 4757 N  N   . UWS K 8 .   ? -6.962  -71.914 -19.812 0.36 76.23  ? 1010 UWS A N   1 
HETATM 4758 C  C   . UWS K 8 .   ? -2.364  -68.573 -21.185 0.36 70.74  ? 1010 UWS A C   1 
HETATM 4759 O  O   . UWS K 8 .   ? -6.778  -72.741 -17.714 0.36 76.16  ? 1010 UWS A O   1 
HETATM 4760 C  C1  . UWS K 8 .   ? -3.439  -69.461 -20.647 0.36 72.14  ? 1010 UWS A C1  1 
HETATM 4761 C  C2  . UWS K 8 .   ? -3.784  -70.756 -21.059 0.36 72.84  ? 1010 UWS A C2  1 
HETATM 4762 C  C3  . UWS K 8 .   ? -4.794  -71.128 -20.260 0.36 75.26  ? 1010 UWS A C3  1 
HETATM 4763 C  C9  . UWS K 8 .   ? -7.455  -72.148 -18.546 0.36 76.88  ? 1010 UWS A C9  1 
HETATM 4764 N  N2  . UWS K 8 .   ? -4.200  -69.057 -19.647 0.36 74.18  ? 1010 UWS A N2  1 
HETATM 4765 O  O1  . UWS K 8 .   ? -5.078  -70.136 -19.392 0.36 74.13  ? 1010 UWS A O1  1 
HETATM 4766 N  N1  . UWS L 8 .   ? -26.395 -46.528 -6.861  0.48 46.62  ? 1011 UWS A N1  1 
HETATM 4767 C  C4  . UWS L 8 .   ? -25.762 -44.599 -8.108  0.48 47.20  ? 1011 UWS A C4  1 
HETATM 4768 C  C5  . UWS L 8 .   ? -27.221 -47.502 -6.600  0.48 47.94  ? 1011 UWS A C5  1 
HETATM 4769 C  C6  . UWS L 8 .   ? -26.810 -48.455 -5.521  0.48 48.21  ? 1011 UWS A C6  1 
HETATM 4770 C  C7  . UWS L 8 .   ? -28.453 -47.683 -7.327  0.48 47.99  ? 1011 UWS A C7  1 
HETATM 4771 C  C8  . UWS L 8 .   ? -28.750 -46.815 -8.317  0.48 48.96  ? 1011 UWS A C8  1 
HETATM 4772 N  N   . UWS L 8 .   ? -26.728 -45.661 -7.880  0.48 48.14  ? 1011 UWS A N   1 
HETATM 4773 C  C   . UWS L 8 .   ? -23.335 -45.182 -12.560 0.48 43.29  ? 1011 UWS A C   1 
HETATM 4774 O  O   . UWS L 8 .   ? -28.074 -44.895 -9.541  0.48 53.87  ? 1011 UWS A O   1 
HETATM 4775 C  C1  . UWS L 8 .   ? -23.753 -45.138 -11.125 0.48 43.94  ? 1011 UWS A C1  1 
HETATM 4776 C  C2  . UWS L 8 .   ? -24.977 -44.711 -10.588 0.48 44.91  ? 1011 UWS A C2  1 
HETATM 4777 C  C3  . UWS L 8 .   ? -24.864 -44.877 -9.261  0.48 45.84  ? 1011 UWS A C3  1 
HETATM 4778 C  C9  . UWS L 8 .   ? -27.870 -45.725 -8.654  0.48 50.26  ? 1011 UWS A C9  1 
HETATM 4779 N  N2  . UWS L 8 .   ? -22.927 -45.546 -10.177 0.48 46.39  ? 1011 UWS A N2  1 
HETATM 4780 O  O1  . UWS L 8 .   ? -23.647 -45.381 -8.966  0.48 43.99  ? 1011 UWS A O1  1 
HETATM 4781 CL CL  . CL  M 7 .   ? -23.056 -48.003 -16.331 1.00 60.91  ? 1012 CL  A CL  1 
HETATM 4782 O  O   . HOH N 9 .   ? -7.705  -48.631 0.928   1.00 61.22  ? 1101 HOH A O   1 
HETATM 4783 O  O   . HOH N 9 .   ? -13.804 -49.074 -30.120 0.34 53.13  ? 1102 HOH A O   1 
HETATM 4784 O  O   . HOH N 9 .   ? 1.161   -21.276 -45.064 1.00 46.88  ? 1103 HOH A O   1 
HETATM 4785 O  O   . HOH N 9 .   ? -22.208 -53.262 -47.008 1.00 59.76  ? 1104 HOH A O   1 
HETATM 4786 O  O   . HOH N 9 .   ? -12.855 -21.629 -41.479 1.00 56.77  ? 1105 HOH A O   1 
HETATM 4787 O  O   . HOH N 9 .   ? -40.235 -61.142 -11.169 1.00 31.95  ? 1106 HOH A O   1 
HETATM 4788 O  O   . HOH N 9 .   ? 0.456   -70.615 -21.118 1.00 38.95  ? 1107 HOH A O   1 
HETATM 4789 O  O   . HOH N 9 .   ? -17.575 -41.532 -37.156 1.00 44.29  ? 1108 HOH A O   1 
HETATM 4790 O  O   . HOH N 9 .   ? -23.232 -64.819 -38.756 1.00 49.58  ? 1109 HOH A O   1 
HETATM 4791 O  O   . HOH N 9 .   ? -32.797 -63.153 -15.045 1.00 32.85  ? 1110 HOH A O   1 
HETATM 4792 O  O   . HOH N 9 .   ? 6.594   -34.912 -43.493 1.00 56.67  ? 1111 HOH A O   1 
HETATM 4793 O  O   . HOH N 9 .   ? -28.881 -62.762 -25.266 1.00 38.82  ? 1112 HOH A O   1 
HETATM 4794 O  O   . HOH N 9 .   ? -11.452 -12.008 -8.440  1.00 64.04  ? 1113 HOH A O   1 
HETATM 4795 O  O   . HOH N 9 .   ? -7.094  -20.280 -26.919 1.00 47.36  ? 1114 HOH A O   1 
HETATM 4796 O  O   . HOH N 9 .   ? -32.749 -51.954 -26.931 1.00 51.03  ? 1115 HOH A O   1 
HETATM 4797 O  O   . HOH N 9 .   ? -39.656 -55.047 -6.479  1.00 48.66  ? 1116 HOH A O   1 
HETATM 4798 O  O   . HOH N 9 .   ? -0.498  -10.833 -29.660 1.00 51.53  ? 1117 HOH A O   1 
HETATM 4799 O  O   . HOH N 9 .   ? -22.616 -27.375 -19.007 1.00 56.13  ? 1118 HOH A O   1 
HETATM 4800 O  O   . HOH N 9 .   ? -22.255 -10.000 -9.097  1.00 54.95  ? 1119 HOH A O   1 
HETATM 4801 O  O   . HOH N 9 .   ? -15.117 -54.138 -39.562 1.00 49.89  ? 1120 HOH A O   1 
HETATM 4802 O  O   . HOH N 9 .   ? -14.710 -17.038 -35.975 1.00 54.27  ? 1121 HOH A O   1 
HETATM 4803 O  O   . HOH N 9 .   ? -19.005 -69.488 -8.203  1.00 30.60  ? 1122 HOH A O   1 
HETATM 4804 O  O   . HOH N 9 .   ? -15.529 -21.963 -18.882 1.00 44.11  ? 1123 HOH A O   1 
HETATM 4805 O  O   . HOH N 9 .   ? 5.975   -32.463 -36.944 0.34 30.59  ? 1124 HOH A O   1 
HETATM 4806 O  O   . HOH N 9 .   ? -31.772 -57.280 -21.776 1.00 36.44  ? 1125 HOH A O   1 
HETATM 4807 O  O   . HOH N 9 .   ? -7.973  -71.068 -28.271 0.34 26.36  ? 1126 HOH A O   1 
HETATM 4808 O  O   . HOH N 9 .   ? -38.173 -67.323 -8.306  1.00 52.40  ? 1127 HOH A O   1 
HETATM 4809 O  O   . HOH N 9 .   ? -32.462 -60.202 -18.727 1.00 44.68  ? 1128 HOH A O   1 
HETATM 4810 O  O   . HOH N 9 .   ? 5.805   -31.213 -19.120 1.00 47.39  ? 1129 HOH A O   1 
HETATM 4811 O  O   . HOH N 9 .   ? -4.314  -53.530 -27.933 1.00 35.69  ? 1130 HOH A O   1 
HETATM 4812 O  O   . HOH N 9 .   ? -38.941 -60.741 -4.449  1.00 48.69  ? 1131 HOH A O   1 
HETATM 4813 O  O   . HOH N 9 .   ? -9.521  -64.825 -30.912 0.36 51.35  ? 1132 HOH A O   1 
HETATM 4814 O  O   . HOH N 9 .   ? -32.247 -70.727 -9.029  1.00 54.63  ? 1133 HOH A O   1 
HETATM 4815 O  O   . HOH N 9 .   ? -22.152 -74.091 -11.562 1.00 34.45  ? 1134 HOH A O   1 
HETATM 4816 O  O   . HOH N 9 .   ? -8.528  -64.577 -6.897  1.00 37.00  ? 1135 HOH A O   1 
HETATM 4817 O  O   . HOH N 9 .   ? 0.092   -32.735 -27.693 1.00 36.20  ? 1136 HOH A O   1 
HETATM 4818 O  O   . HOH N 9 .   ? -32.848 -48.863 -18.807 1.00 55.14  ? 1137 HOH A O   1 
HETATM 4819 O  O   . HOH N 9 .   ? -20.370 -47.117 -10.290 0.48 25.90  ? 1138 HOH A O   1 
HETATM 4820 O  O   . HOH N 9 .   ? -22.585 -65.674 -23.727 1.00 42.34  ? 1139 HOH A O   1 
HETATM 4821 O  O   . HOH N 9 .   ? -5.038  -15.261 -27.855 1.00 51.87  ? 1140 HOH A O   1 
HETATM 4822 O  O   . HOH N 9 .   ? -24.815 -14.082 -4.657  1.00 62.52  ? 1141 HOH A O   1 
HETATM 4823 O  O   . HOH N 9 .   ? -34.521 -20.325 -23.829 1.00 55.56  ? 1142 HOH A O   1 
HETATM 4824 O  O   . HOH N 9 .   ? -6.172  -69.524 -8.064  0.36 37.47  ? 1143 HOH A O   1 
HETATM 4825 O  O   . HOH N 9 .   ? -5.513  -60.025 -0.834  1.00 42.16  ? 1144 HOH A O   1 
HETATM 4826 O  O   . HOH N 9 .   ? -8.786  -26.003 -44.286 0.34 13.21  ? 1145 HOH A O   1 
HETATM 4827 O  O   . HOH N 9 .   ? -14.716 -43.596 -21.151 1.00 72.61  ? 1146 HOH A O   1 
HETATM 4828 O  O   . HOH N 9 .   ? 5.405   -29.915 -21.521 1.00 36.27  ? 1147 HOH A O   1 
HETATM 4829 O  O   . HOH N 9 .   ? 11.354  -34.542 -32.758 1.00 43.75  ? 1148 HOH A O   1 
HETATM 4830 O  O   . HOH N 9 .   ? -27.154 -56.973 -39.928 1.00 57.50  ? 1149 HOH A O   1 
HETATM 4831 O  O   . HOH N 9 .   ? -4.008  -57.336 -9.908  1.00 39.75  ? 1150 HOH A O   1 
HETATM 4832 O  O   . HOH N 9 .   ? -28.043 -18.247 -34.699 1.00 54.22  ? 1151 HOH A O   1 
HETATM 4833 O  O   . HOH N 9 .   ? -9.388  -21.312 -26.977 1.00 38.70  ? 1152 HOH A O   1 
HETATM 4834 O  O   . HOH N 9 .   ? -17.925 -65.555 -36.195 1.00 55.65  ? 1153 HOH A O   1 
HETATM 4835 O  O   . HOH N 9 .   ? -15.024 -70.578 -17.876 0.36 43.84  ? 1154 HOH A O   1 
HETATM 4836 O  O   . HOH N 9 .   ? 9.192   -17.531 -40.536 1.00 63.27  ? 1155 HOH A O   1 
HETATM 4837 O  O   . HOH N 9 .   ? -3.799  -61.393 -15.487 1.00 37.00  ? 1156 HOH A O   1 
HETATM 4838 O  O   . HOH N 9 .   ? -19.423 -27.172 -39.875 1.00 36.65  ? 1157 HOH A O   1 
HETATM 4839 O  O   . HOH N 9 .   ? -9.117  -58.799 -13.319 1.00 30.97  ? 1158 HOH A O   1 
HETATM 4840 O  O   . HOH N 9 .   ? -3.188  -55.104 -17.952 1.00 31.89  ? 1159 HOH A O   1 
HETATM 4841 O  O   . HOH N 9 .   ? -19.566 -17.124 -10.778 1.00 54.28  ? 1160 HOH A O   1 
HETATM 4842 O  O   . HOH N 9 .   ? -0.059  -31.078 -22.876 1.00 32.27  ? 1161 HOH A O   1 
HETATM 4843 O  O   . HOH N 9 .   ? -26.288 -30.379 -23.238 1.00 57.92  ? 1162 HOH A O   1 
HETATM 4844 O  O   . HOH N 9 .   ? -39.052 -56.988 -20.464 1.00 53.76  ? 1163 HOH A O   1 
HETATM 4845 O  O   . HOH N 9 .   ? -22.248 -42.216 0.650   1.00 76.05  ? 1164 HOH A O   1 
HETATM 4846 O  O   . HOH N 9 .   ? -24.459 -69.189 -27.614 1.00 49.05  ? 1165 HOH A O   1 
HETATM 4847 O  O   . HOH N 9 .   ? 2.720   -39.267 -26.799 1.00 33.49  ? 1166 HOH A O   1 
HETATM 4848 O  O   . HOH N 9 .   ? -18.904 -65.117 -7.168  1.00 24.61  ? 1167 HOH A O   1 
HETATM 4849 O  O   . HOH N 9 .   ? -31.793 -60.029 -15.841 1.00 36.18  ? 1168 HOH A O   1 
HETATM 4850 O  O   . HOH N 9 .   ? -10.972 -62.242 -18.785 1.00 24.86  ? 1169 HOH A O   1 
HETATM 4851 O  O   . HOH N 9 .   ? -5.400  -58.280 -29.916 1.00 47.30  ? 1170 HOH A O   1 
HETATM 4852 O  O   . HOH N 9 .   ? -20.681 -29.378 -24.935 1.00 44.25  ? 1171 HOH A O   1 
HETATM 4853 O  O   . HOH N 9 .   ? -12.360 -58.021 -0.000  0.50 24.43  ? 1172 HOH A O   1 
HETATM 4854 O  O   . HOH N 9 .   ? -26.585 -25.480 -33.207 1.00 32.68  ? 1173 HOH A O   1 
HETATM 4855 O  O   . HOH N 9 .   ? -10.932 -47.989 -39.161 1.00 32.48  ? 1174 HOH A O   1 
HETATM 4856 O  O   . HOH N 9 .   ? -26.385 -71.255 -3.567  1.00 51.77  ? 1175 HOH A O   1 
HETATM 4857 O  O   . HOH N 9 .   ? -23.029 -20.750 -37.632 1.00 45.76  ? 1176 HOH A O   1 
HETATM 4858 O  O   . HOH N 9 .   ? 1.663   -36.615 -41.989 0.34 55.48  ? 1177 HOH A O   1 
HETATM 4859 O  O   . HOH N 9 .   ? 0.214   -67.848 -18.671 0.36 21.56  ? 1178 HOH A O   1 
HETATM 4860 O  O   . HOH N 9 .   ? 4.606   -16.319 -21.267 1.00 56.36  ? 1179 HOH A O   1 
HETATM 4861 O  O   . HOH N 9 .   ? -7.379  -47.297 -18.153 1.00 41.59  ? 1180 HOH A O   1 
HETATM 4862 O  O   . HOH N 9 .   ? -42.359 -62.753 -4.949  1.00 52.66  ? 1181 HOH A O   1 
HETATM 4863 O  O   . HOH N 9 .   ? -34.737 -62.778 0.566   1.00 31.68  ? 1182 HOH A O   1 
HETATM 4864 O  O   . HOH N 9 .   ? -12.301 -36.596 -39.572 1.00 39.67  ? 1183 HOH A O   1 
HETATM 4865 O  O   . HOH N 9 .   ? -35.767 -66.261 -0.707  1.00 40.42  ? 1184 HOH A O   1 
HETATM 4866 O  O   . HOH N 9 .   ? 1.647   -32.206 -38.667 1.00 37.43  ? 1185 HOH A O   1 
HETATM 4867 O  O   . HOH N 9 .   ? -21.636 -65.997 -4.540  1.00 45.59  ? 1186 HOH A O   1 
HETATM 4868 O  O   . HOH N 9 .   ? -18.023 -61.926 -3.032  1.00 28.18  ? 1187 HOH A O   1 
HETATM 4869 O  O   . HOH N 9 .   ? -12.851 -42.289 -39.039 0.34 44.33  ? 1188 HOH A O   1 
HETATM 4870 O  O   . HOH N 9 .   ? 5.703   -38.747 -24.248 1.00 47.56  ? 1189 HOH A O   1 
HETATM 4871 O  O   . HOH N 9 .   ? -23.117 -27.351 -24.527 1.00 52.28  ? 1190 HOH A O   1 
HETATM 4872 O  O   . HOH N 9 .   ? -5.190  -48.489 -28.614 1.00 35.95  ? 1191 HOH A O   1 
HETATM 4873 O  O   . HOH N 9 .   ? -5.978  -68.332 -27.387 1.00 34.56  ? 1192 HOH A O   1 
HETATM 4874 O  O   . HOH N 9 .   ? -38.211 -60.737 -14.361 1.00 45.18  ? 1193 HOH A O   1 
HETATM 4875 O  O   . HOH N 9 .   ? -13.975 -49.046 -32.429 0.34 45.85  ? 1194 HOH A O   1 
HETATM 4876 O  O   . HOH N 9 .   ? -14.934 -34.683 -28.975 1.00 25.77  ? 1195 HOH A O   1 
HETATM 4877 O  O   . HOH N 9 .   ? -19.173 -20.445 -40.536 1.00 47.37  ? 1196 HOH A O   1 
HETATM 4878 O  O   . HOH N 9 .   ? -22.471 -50.854 -9.152  1.00 34.01  ? 1197 HOH A O   1 
HETATM 4879 O  O   . HOH N 9 .   ? -14.680 -63.898 -0.426  1.00 32.46  ? 1198 HOH A O   1 
HETATM 4880 O  O   . HOH N 9 .   ? -27.923 -22.841 -26.367 1.00 33.21  ? 1199 HOH A O   1 
HETATM 4881 O  O   . HOH N 9 .   ? -30.129 -56.509 -34.429 1.00 51.06  ? 1200 HOH A O   1 
HETATM 4882 O  O   . HOH N 9 .   ? 4.278   -28.808 -43.941 1.00 51.08  ? 1201 HOH A O   1 
HETATM 4883 O  O   . HOH N 9 .   ? -29.585 -33.411 -28.445 1.00 55.82  ? 1202 HOH A O   1 
HETATM 4884 O  O   . HOH N 9 .   ? -13.755 -51.109 -42.902 1.00 52.41  ? 1203 HOH A O   1 
HETATM 4885 O  O   . HOH N 9 .   ? 10.477  -26.785 -28.907 1.00 45.89  ? 1204 HOH A O   1 
HETATM 4886 O  O   . HOH N 9 .   ? -41.211 -58.021 -9.969  0.50 39.60  ? 1205 HOH A O   1 
HETATM 4887 O  O   . HOH N 9 .   ? -6.467  -36.935 -20.682 1.00 52.74  ? 1206 HOH A O   1 
HETATM 4888 O  O   . HOH N 9 .   ? 10.714  -38.609 -29.588 1.00 52.42  ? 1207 HOH A O   1 
HETATM 4889 O  O   . HOH N 9 .   ? -30.062 -60.623 -23.133 1.00 36.62  ? 1208 HOH A O   1 
HETATM 4890 O  O   . HOH N 9 .   ? -20.717 -65.887 -1.321  1.00 45.70  ? 1209 HOH A O   1 
HETATM 4891 O  O   . HOH N 9 .   ? -3.310  -19.974 -23.284 1.00 45.70  ? 1210 HOH A O   1 
HETATM 4892 O  O   . HOH N 9 .   ? -17.028 -51.752 -15.405 1.00 23.11  ? 1211 HOH A O   1 
HETATM 4893 O  O   . HOH N 9 .   ? -35.007 -49.853 -12.829 1.00 50.81  ? 1212 HOH A O   1 
HETATM 4894 O  O   . HOH N 9 .   ? -15.421 -65.481 -33.866 1.00 61.10  ? 1213 HOH A O   1 
HETATM 4895 O  O   . HOH N 9 .   ? 3.747   -37.463 -44.110 1.00 54.69  ? 1214 HOH A O   1 
HETATM 4896 O  O   . HOH N 9 .   ? -37.130 -50.362 -5.309  1.00 38.80  ? 1215 HOH A O   1 
HETATM 4897 O  O   . HOH N 9 .   ? -27.942 -16.914 -32.138 1.00 41.62  ? 1216 HOH A O   1 
HETATM 4898 O  O   . HOH N 9 .   ? -14.281 -56.300 -1.589  1.00 22.30  ? 1217 HOH A O   1 
HETATM 4899 O  O   . HOH N 9 .   ? -15.454 -26.942 -45.979 1.00 54.57  ? 1218 HOH A O   1 
HETATM 4900 O  O   . HOH N 9 .   ? -8.399  -16.807 -38.931 1.00 50.68  ? 1219 HOH A O   1 
HETATM 4901 O  O   . HOH N 9 .   ? -27.241 -65.043 -40.016 1.00 59.03  ? 1220 HOH A O   1 
HETATM 4902 O  O   . HOH N 9 .   ? -20.752 -31.475 -29.123 1.00 39.28  ? 1221 HOH A O   1 
HETATM 4903 O  O   . HOH N 9 .   ? 9.259   -23.928 -36.000 1.00 59.56  ? 1222 HOH A O   1 
HETATM 4904 O  O   . HOH N 9 .   ? -22.657 -37.285 -37.479 1.00 52.82  ? 1223 HOH A O   1 
HETATM 4905 O  O   . HOH N 9 .   ? -13.638 -53.453 -1.488  1.00 34.29  ? 1224 HOH A O   1 
HETATM 4906 O  O   . HOH N 9 .   ? -1.071  -52.839 -35.732 1.00 64.13  ? 1225 HOH A O   1 
HETATM 4907 O  O   . HOH N 9 .   ? -5.843  -50.247 -18.939 1.00 33.34  ? 1226 HOH A O   1 
HETATM 4908 O  O   . HOH N 9 .   ? -0.459  -35.677 -27.966 1.00 40.17  ? 1227 HOH A O   1 
HETATM 4909 O  O   . HOH N 9 .   ? -17.309 -56.904 -44.270 0.50 34.25  ? 1228 HOH A O   1 
HETATM 4910 O  O   . HOH N 9 .   ? 1.016   -41.612 -24.341 1.00 46.71  ? 1229 HOH A O   1 
HETATM 4911 O  O   . HOH N 9 .   ? -31.918 -71.847 -12.953 0.36 35.03  ? 1230 HOH A O   1 
HETATM 4912 O  O   . HOH N 9 .   ? -5.656  -59.062 -12.040 1.00 47.73  ? 1231 HOH A O   1 
HETATM 4913 O  O   . HOH N 9 .   ? -22.806 -29.558 -14.410 1.00 70.05  ? 1232 HOH A O   1 
HETATM 4914 O  O   . HOH N 9 .   ? -25.008 -53.267 -1.892  1.00 34.82  ? 1233 HOH A O   1 
HETATM 4915 O  O   . HOH N 9 .   ? -21.096 -49.167 -34.948 1.00 50.42  ? 1234 HOH A O   1 
HETATM 4916 O  O   . HOH N 9 .   ? -26.118 -50.414 -3.360  0.48 36.84  ? 1235 HOH A O   1 
HETATM 4917 O  O   . HOH N 9 .   ? -5.749  -58.269 -37.099 1.00 58.17  ? 1236 HOH A O   1 
HETATM 4918 O  O   . HOH N 9 .   ? -28.180 -49.227 -31.559 1.00 62.57  ? 1237 HOH A O   1 
HETATM 4919 O  O   . HOH N 9 .   ? -20.537 -67.142 -25.343 1.00 35.59  ? 1238 HOH A O   1 
HETATM 4920 O  O   . HOH N 9 .   ? -23.009 -33.436 -36.760 1.00 35.30  ? 1239 HOH A O   1 
HETATM 4921 O  O   . HOH N 9 .   ? 4.122   -26.562 -29.165 1.00 49.67  ? 1240 HOH A O   1 
HETATM 4922 O  O   . HOH N 9 .   ? -4.250  -22.963 -24.967 1.00 42.84  ? 1241 HOH A O   1 
HETATM 4923 O  O   . HOH N 9 .   ? 7.397   -49.325 -30.621 1.00 61.02  ? 1242 HOH A O   1 
HETATM 4924 O  O   . HOH N 9 .   ? -14.820 -54.076 -4.072  1.00 33.04  ? 1243 HOH A O   1 
HETATM 4925 O  O   . HOH N 9 .   ? -14.194 -52.117 -5.805  1.00 32.26  ? 1244 HOH A O   1 
HETATM 4926 O  O   . HOH N 9 .   ? -29.893 -59.420 -19.836 1.00 37.90  ? 1245 HOH A O   1 
HETATM 4927 O  O   . HOH N 9 .   ? -38.904 -54.793 -19.038 1.00 45.91  ? 1246 HOH A O   1 
HETATM 4928 O  O   . HOH N 9 .   ? -4.151  -56.947 -13.326 1.00 50.35  ? 1247 HOH A O   1 
HETATM 4929 O  O   . HOH N 9 .   ? -12.441 -75.127 -26.688 1.00 63.62  ? 1248 HOH A O   1 
HETATM 4930 O  O   . HOH N 9 .   ? -18.240 -69.235 -24.840 1.00 41.79  ? 1249 HOH A O   1 
HETATM 4931 O  O   . HOH N 9 .   ? -35.388 -59.086 -0.733  1.00 55.70  ? 1250 HOH A O   1 
HETATM 4932 O  O   . HOH N 9 .   ? -19.963 -37.888 -36.629 1.00 35.23  ? 1251 HOH A O   1 
HETATM 4933 O  O   . HOH N 9 .   ? -4.482  -62.231 -4.619  1.00 42.39  ? 1252 HOH A O   1 
HETATM 4934 O  O   . HOH N 9 .   ? -35.739 -58.317 -26.970 1.00 55.85  ? 1253 HOH A O   1 
HETATM 4935 O  O   . HOH N 9 .   ? 7.536   -22.029 -23.732 1.00 51.96  ? 1254 HOH A O   1 
HETATM 4936 O  O   . HOH N 9 .   ? -5.811  -48.922 -21.248 1.00 32.42  ? 1255 HOH A O   1 
HETATM 4937 O  O   . HOH N 9 .   ? -4.891  -56.257 -31.552 1.00 33.79  ? 1256 HOH A O   1 
HETATM 4938 O  O   . HOH N 9 .   ? -33.528 -57.317 -19.677 1.00 57.64  ? 1257 HOH A O   1 
HETATM 4939 O  O   . HOH N 9 .   ? -13.027 -53.471 -40.687 1.00 55.83  ? 1258 HOH A O   1 
HETATM 4940 O  O   . HOH N 9 .   ? -36.130 -58.373 -20.659 1.00 64.56  ? 1259 HOH A O   1 
HETATM 4941 O  O   . HOH N 9 .   ? -3.016  -57.928 -24.518 1.00 28.03  ? 1260 HOH A O   1 
HETATM 4942 O  O   . HOH N 9 .   ? -17.206 -71.725 -22.726 1.00 56.32  ? 1261 HOH A O   1 
HETATM 4943 O  O   . HOH N 9 .   ? -14.125 -44.656 -3.842  1.00 70.51  ? 1262 HOH A O   1 
HETATM 4944 O  O   . HOH N 9 .   ? -8.818  -37.091 -19.283 1.00 56.28  ? 1263 HOH A O   1 
HETATM 4945 O  O   . HOH N 9 .   ? -26.269 -20.248 -38.465 1.00 71.47  ? 1264 HOH A O   1 
HETATM 4946 O  O   . HOH N 9 .   ? -19.936 -46.001 -25.233 1.00 43.50  ? 1265 HOH A O   1 
HETATM 4947 O  O   . HOH N 9 .   ? 8.568   -40.461 -31.484 1.00 51.26  ? 1266 HOH A O   1 
HETATM 4948 O  O   . HOH N 9 .   ? 7.913   -42.995 -35.732 1.00 51.43  ? 1267 HOH A O   1 
HETATM 4949 O  O   . HOH N 9 .   ? -37.621 -68.062 -12.400 1.00 57.25  ? 1268 HOH A O   1 
HETATM 4950 O  O   . HOH N 9 .   ? -9.003  -70.848 -14.679 1.00 41.07  ? 1269 HOH A O   1 
HETATM 4951 O  O   . HOH N 9 .   ? -15.013 -48.488 -18.554 1.00 41.92  ? 1270 HOH A O   1 
HETATM 4952 O  O   . HOH N 9 .   ? -35.904 -54.134 -3.282  1.00 41.00  ? 1271 HOH A O   1 
HETATM 4953 O  O   . HOH N 9 .   ? -14.922 -45.055 -10.641 1.00 62.31  ? 1272 HOH A O   1 
HETATM 4954 O  O   . HOH N 9 .   ? -23.694 -47.295 -33.260 0.34 25.61  ? 1273 HOH A O   1 
HETATM 4955 O  O   . HOH N 9 .   ? -0.877  -32.478 -25.179 1.00 35.16  ? 1274 HOH A O   1 
HETATM 4956 O  O   . HOH N 9 .   ? -7.470  -61.544 -34.630 0.36 53.67  ? 1275 HOH A O   1 
HETATM 4957 O  O   . HOH N 9 .   ? 10.504  -29.309 -34.104 1.00 50.32  ? 1276 HOH A O   1 
HETATM 4958 O  O   . HOH N 9 .   ? 0.526   -45.151 -36.727 1.00 49.60  ? 1277 HOH A O   1 
HETATM 4959 O  O   . HOH N 9 .   ? -24.569 -68.357 -38.283 1.00 56.01  ? 1278 HOH A O   1 
HETATM 4960 O  O   . HOH N 9 .   ? 3.640   -31.317 -37.049 1.00 36.58  ? 1279 HOH A O   1 
HETATM 4961 O  O   . HOH N 9 .   ? -22.796 -75.136 -9.201  1.00 42.00  ? 1280 HOH A O   1 
HETATM 4962 O  O   . HOH N 9 .   ? -11.683 -41.090 -20.204 1.00 61.94  ? 1281 HOH A O   1 
HETATM 4963 O  O   . HOH N 9 .   ? -15.418 -54.667 -43.813 1.00 51.19  ? 1282 HOH A O   1 
HETATM 4964 O  O   . HOH N 9 .   ? 1.048   -38.433 -21.026 1.00 48.83  ? 1283 HOH A O   1 
HETATM 4965 O  O   . HOH N 9 .   ? -7.619  -29.752 -45.975 1.00 49.11  ? 1284 HOH A O   1 
HETATM 4966 O  O   . HOH N 9 .   ? -29.665 -35.407 -30.174 1.00 69.85  ? 1285 HOH A O   1 
HETATM 4967 O  O   . HOH N 9 .   ? -0.343  -55.417 -33.179 1.00 53.60  ? 1286 HOH A O   1 
HETATM 4968 O  O   . HOH N 9 .   ? -34.044 -70.043 -18.402 1.00 46.74  ? 1287 HOH A O   1 
HETATM 4969 O  O   . HOH N 9 .   ? 13.320  -30.523 -19.529 1.00 57.25  ? 1288 HOH A O   1 
HETATM 4970 O  O   . HOH N 9 .   ? 9.860   -38.078 -39.153 1.00 52.90  ? 1289 HOH A O   1 
HETATM 4971 O  O   . HOH N 9 .   ? -14.582 -45.757 2.779   1.00 65.24  ? 1290 HOH A O   1 
HETATM 4972 O  O   . HOH N 9 .   ? -22.000 -31.543 -39.545 1.00 47.42  ? 1291 HOH A O   1 
HETATM 4973 O  O   . HOH N 9 .   ? -23.284 -49.252 -42.090 1.00 47.55  ? 1292 HOH A O   1 
HETATM 4974 O  O   . HOH N 9 .   ? -31.989 -18.798 -30.973 1.00 51.86  ? 1293 HOH A O   1 
HETATM 4975 O  O   . HOH N 9 .   ? -34.725 -59.428 -29.018 1.00 53.85  ? 1294 HOH A O   1 
HETATM 4976 O  O   . HOH N 9 .   ? -2.543  -40.287 -46.165 1.00 54.17  ? 1295 HOH A O   1 
HETATM 4977 O  O   . HOH N 9 .   ? -10.717 -46.246 3.770   1.00 53.59  ? 1296 HOH A O   1 
HETATM 4978 O  O   . HOH N 9 .   ? -17.854 -43.532 -8.017  0.48 55.61  ? 1297 HOH A O   1 
HETATM 4979 O  O   . HOH N 9 .   ? -8.706  -35.709 -44.928 1.00 58.43  ? 1298 HOH A O   1 
HETATM 4980 O  O   . HOH N 9 .   ? -4.331  -52.494 -38.673 1.00 60.77  ? 1299 HOH A O   1 
HETATM 4981 O  O   . HOH N 9 .   ? -10.143 -75.362 -9.110  1.00 62.97  ? 1300 HOH A O   1 
HETATM 4982 O  O   . HOH N 9 .   ? -24.900 -27.238 -20.152 1.00 61.30  ? 1301 HOH A O   1 
HETATM 4983 O  O   . HOH N 9 .   ? -3.773  -56.349 -7.263  1.00 38.82  ? 1302 HOH A O   1 
HETATM 4984 O  O   . HOH N 9 .   ? -37.403 -52.268 -12.803 1.00 31.28  ? 1303 HOH A O   1 
HETATM 4985 O  O   . HOH N 9 .   ? 0.694   -31.154 -46.917 1.00 54.06  ? 1304 HOH A O   1 
HETATM 4986 O  O   . HOH N 9 .   ? -27.179 -26.653 -35.632 1.00 44.09  ? 1305 HOH A O   1 
HETATM 4987 O  O   . HOH N 9 .   ? -37.525 -54.783 -24.801 1.00 64.84  ? 1306 HOH A O   1 
HETATM 4988 O  O   . HOH N 9 .   ? -29.767 -62.362 -33.950 0.50 43.37  ? 1307 HOH A O   1 
HETATM 4989 O  O   . HOH N 9 .   ? -3.715  -70.699 -8.998  1.00 41.49  ? 1308 HOH A O   1 
HETATM 4990 O  O   . HOH N 9 .   ? 11.636  -36.572 -18.974 0.34 17.67  ? 1309 HOH A O   1 
HETATM 4991 O  O   . HOH N 9 .   ? -19.274 -64.401 -2.936  1.00 45.90  ? 1310 HOH A O   1 
HETATM 4992 O  O   . HOH N 9 .   ? -26.377 -26.827 -42.290 1.00 52.64  ? 1311 HOH A O   1 
HETATM 4993 O  O   . HOH N 9 .   ? -6.157  -42.979 -20.766 1.00 51.15  ? 1312 HOH A O   1 
HETATM 4994 O  O   . HOH N 9 .   ? -7.082  -57.318 -0.841  1.00 55.89  ? 1313 HOH A O   1 
HETATM 4995 O  O   . HOH N 9 .   ? -0.044  -48.003 -36.450 1.00 48.24  ? 1314 HOH A O   1 
HETATM 4996 O  O   . HOH N 9 .   ? -1.732  -68.459 -14.001 0.36 30.78  ? 1315 HOH A O   1 
HETATM 4997 O  O   . HOH N 9 .   ? -35.046 -67.507 -5.559  1.00 59.39  ? 1316 HOH A O   1 
HETATM 4998 O  O   . HOH N 9 .   ? -24.152 -58.004 -46.824 1.00 51.13  ? 1317 HOH A O   1 
HETATM 4999 O  O   . HOH N 9 .   ? -16.242 -49.054 -16.293 1.00 27.19  ? 1318 HOH A O   1 
HETATM 5000 O  O   . HOH N 9 .   ? 2.770   -64.473 -20.676 1.00 25.84  ? 1319 HOH A O   1 
HETATM 5001 O  O   . HOH N 9 .   ? -11.691 -71.821 -15.523 1.00 28.34  ? 1320 HOH A O   1 
HETATM 5002 O  O   . HOH N 9 .   ? -39.480 -63.344 -1.941  0.50 43.77  ? 1321 HOH A O   1 
HETATM 5003 O  O   . HOH N 9 .   ? -14.976 -68.802 -19.768 0.36 26.64  ? 1322 HOH A O   1 
HETATM 5004 O  O   . HOH N 9 .   ? -26.633 -67.634 -27.918 1.00 31.43  ? 1323 HOH A O   1 
HETATM 5005 O  O   . HOH N 9 .   ? -33.891 -46.753 -15.563 1.00 61.74  ? 1324 HOH A O   1 
HETATM 5006 O  O   . HOH N 9 .   ? -14.887 -56.601 -41.902 1.00 35.61  ? 1325 HOH A O   1 
HETATM 5007 O  O   . HOH N 9 .   ? -2.568  -57.761 -27.399 1.00 30.94  ? 1326 HOH A O   1 
HETATM 5008 O  O   . HOH N 9 .   ? -40.909 -23.940 -18.282 1.00 74.89  ? 1327 HOH A O   1 
HETATM 5009 O  O   . HOH N 9 .   ? -20.193 -31.253 -26.467 1.00 31.57  ? 1328 HOH A O   1 
HETATM 5010 O  O   . HOH N 9 .   ? -13.420 -68.305 -6.183  1.00 46.77  ? 1329 HOH A O   1 
HETATM 5011 O  O   . HOH N 9 .   ? -13.182 -32.674 -20.370 1.00 35.47  ? 1330 HOH A O   1 
HETATM 5012 O  O   . HOH N 9 .   ? -12.512 -37.723 -22.238 1.00 58.10  ? 1331 HOH A O   1 
HETATM 5013 O  O   . HOH N 9 .   ? -10.679 -17.237 -40.138 1.00 61.23  ? 1332 HOH A O   1 
HETATM 5014 O  O   . HOH N 9 .   ? -6.374  -32.934 -16.143 0.34 29.52  ? 1333 HOH A O   1 
HETATM 5015 O  O   . HOH N 9 .   ? -21.981 -41.549 -34.160 1.00 66.56  ? 1334 HOH A O   1 
HETATM 5016 O  O   . HOH N 9 .   ? -9.920  -54.595 -41.849 1.00 63.78  ? 1335 HOH A O   1 
HETATM 5017 O  O   . HOH N 9 .   ? -21.170 -43.348 -41.187 1.00 59.13  ? 1336 HOH A O   1 
HETATM 5018 O  O   . HOH N 9 .   ? -35.630 -50.532 -23.088 1.00 56.64  ? 1337 HOH A O   1 
HETATM 5019 O  O   . HOH N 9 .   ? -17.088 -46.586 -11.048 1.00 59.31  ? 1338 HOH A O   1 
HETATM 5020 O  O   . HOH N 9 .   ? -13.196 -11.214 -32.052 1.00 63.55  ? 1339 HOH A O   1 
HETATM 5021 O  O   . HOH N 9 .   ? 4.386   -62.357 -20.008 1.00 24.92  ? 1340 HOH A O   1 
HETATM 5022 O  O   . HOH N 9 .   ? -8.800  -63.323 -33.110 0.36 43.23  ? 1341 HOH A O   1 
HETATM 5023 O  O   . HOH N 9 .   ? -12.407 -43.668 -16.397 1.00 52.74  ? 1342 HOH A O   1 
HETATM 5024 O  O   . HOH N 9 .   ? -0.053  -45.679 -42.979 1.00 62.48  ? 1343 HOH A O   1 
HETATM 5025 O  O   . HOH N 9 .   ? -25.605 -23.653 -41.679 1.00 69.83  ? 1344 HOH A O   1 
HETATM 5026 O  O   . HOH N 9 .   ? -37.554 -60.550 -0.433  0.50 47.82  ? 1345 HOH A O   1 
HETATM 5027 O  O   . HOH N 9 .   ? -3.718  -15.449 -20.082 1.00 55.28  ? 1346 HOH A O   1 
HETATM 5028 O  O   . HOH N 9 .   ? -32.214 -13.095 -9.346  1.00 60.09  ? 1347 HOH A O   1 
HETATM 5029 O  O   . HOH N 9 .   ? 6.444   -20.429 -43.298 1.00 69.59  ? 1348 HOH A O   1 
HETATM 5030 O  O   . HOH N 9 .   ? 3.412   -33.888 -14.068 1.00 48.84  ? 1349 HOH A O   1 
HETATM 5031 O  O   . HOH N 9 .   ? 8.227   -47.302 -29.061 1.00 70.66  ? 1350 HOH A O   1 
HETATM 5032 O  O   . HOH N 9 .   ? -10.717 -39.500 -39.880 0.34 36.65  ? 1351 HOH A O   1 
HETATM 5033 O  O   . HOH N 9 .   ? -27.090 -73.607 -4.728  1.00 46.74  ? 1352 HOH A O   1 
HETATM 5034 O  O   . HOH N 9 .   ? -37.872 -65.032 -20.445 0.50 38.77  ? 1353 HOH A O   1 
HETATM 5035 O  O   . HOH N 9 .   ? -2.991  -55.458 -29.000 1.00 36.80  ? 1354 HOH A O   1 
HETATM 5036 O  O   . HOH N 9 .   ? -1.945  -70.743 -17.464 0.36 18.95  ? 1355 HOH A O   1 
HETATM 5037 O  O   . HOH N 9 .   ? -37.699 -37.509 -25.953 1.00 56.75  ? 1356 HOH A O   1 
HETATM 5038 O  O   . HOH N 9 .   ? -2.695  -66.005 -14.150 0.36 36.03  ? 1357 HOH A O   1 
HETATM 5039 O  O   . HOH N 9 .   ? -36.857 -64.614 -0.025  0.50 24.26  ? 1358 HOH A O   1 
HETATM 5040 O  O   . HOH N 9 .   ? -3.463  -52.030 2.951   1.00 66.47  ? 1359 HOH A O   1 
HETATM 5041 O  O   . HOH N 9 .   ? -4.814  -47.250 -21.550 1.00 35.76  ? 1360 HOH A O   1 
HETATM 5042 O  O   . HOH N 9 .   ? -11.371 -66.749 -30.663 0.36 38.01  ? 1361 HOH A O   1 
HETATM 5043 O  O   . HOH N 9 .   ? -15.452 -41.653 -38.581 1.00 41.18  ? 1362 HOH A O   1 
HETATM 5044 O  O   . HOH N 9 .   ? -17.727 -27.864 -44.609 1.00 58.51  ? 1363 HOH A O   1 
HETATM 5045 O  O   . HOH N 9 .   ? -0.675  -54.146 -18.007 0.36 21.61  ? 1364 HOH A O   1 
HETATM 5046 O  O   . HOH N 9 .   ? -3.492  -51.945 -4.632  1.00 66.12  ? 1365 HOH A O   1 
HETATM 5047 O  O   . HOH N 9 .   ? -38.187 -51.928 -3.555  1.00 53.59  ? 1366 HOH A O   1 
HETATM 5048 O  O   . HOH N 9 .   ? -2.992  -51.511 -15.464 1.00 57.09  ? 1367 HOH A O   1 
HETATM 5049 O  O   . HOH N 9 .   ? -42.408 -66.243 -10.345 1.00 64.23  ? 1368 HOH A O   1 
HETATM 5050 O  O   . HOH N 9 .   ? 0.000   -58.021 -16.285 0.50 55.00  ? 1369 HOH A O   1 
HETATM 5051 O  O   . HOH N 9 .   ? -36.417 -56.251 -4.390  0.50 37.08  ? 1370 HOH A O   1 
HETATM 5052 O  O   . HOH N 9 .   ? 0.000   -58.021 -28.574 0.36 27.74  ? 1371 HOH A O   1 
HETATM 5053 O  O   . HOH N 9 .   ? -7.992  -30.273 -13.669 0.34 24.10  ? 1372 HOH A O   1 
HETATM 5054 O  O   . HOH N 9 .   ? -30.707 -16.754 -32.059 1.00 57.19  ? 1373 HOH A O   1 
HETATM 5055 O  O   . HOH N 9 .   ? -18.400 -34.438 -43.739 0.34 35.38  ? 1374 HOH A O   1 
HETATM 5056 O  O   . HOH N 9 .   ? -13.331 -22.146 15.320  1.00 70.85  ? 1375 HOH A O   1 
HETATM 5057 O  O   . HOH N 9 .   ? 4.543   -6.973  -37.847 1.00 73.01  ? 1376 HOH A O   1 
HETATM 5058 O  O   . HOH N 9 .   ? -39.963 -24.264 -26.509 1.00 55.27  ? 1377 HOH A O   1 
HETATM 5059 O  O   . HOH N 9 .   ? -15.831 -68.962 -5.961  1.00 34.55  ? 1378 HOH A O   1 
HETATM 5060 O  O   . HOH N 9 .   ? -10.177 -33.844 -44.663 1.00 65.60  ? 1379 HOH A O   1 
HETATM 5061 O  O   . HOH N 9 .   ? -35.003 -70.439 -13.462 1.00 62.11  ? 1380 HOH A O   1 
HETATM 5062 O  O   . HOH N 9 .   ? -34.807 -49.387 -20.799 1.00 60.13  ? 1381 HOH A O   1 
HETATM 5063 O  O   . HOH N 9 .   ? -10.512 -68.192 -37.977 1.00 72.30  ? 1382 HOH A O   1 
HETATM 5064 O  O   . HOH N 9 .   ? 16.679  -34.970 -25.908 1.00 57.36  ? 1383 HOH A O   1 
HETATM 5065 O  O   . HOH N 9 .   ? -10.215 -38.138 -43.403 0.34 20.15  ? 1384 HOH A O   1 
HETATM 5066 O  O   . HOH N 9 .   ? -41.335 -56.613 -13.541 1.00 43.21  ? 1385 HOH A O   1 
HETATM 5067 O  O   . HOH N 9 .   ? -4.941  -64.863 -30.767 1.00 59.43  ? 1386 HOH A O   1 
HETATM 5068 O  O   . HOH N 9 .   ? -4.578  -49.176 2.973   1.00 68.01  ? 1387 HOH A O   1 
HETATM 5069 O  O   . HOH N 9 .   ? -19.035 -39.716 -38.705 0.34 44.65  ? 1388 HOH A O   1 
HETATM 5070 O  O   . HOH N 9 .   ? -26.156 -2.047  -28.701 1.00 66.63  ? 1389 HOH A O   1 
HETATM 5071 O  O   . HOH N 9 .   ? -3.052  -60.343 -5.845  1.00 68.14  ? 1390 HOH A O   1 
HETATM 5072 O  O   . HOH N 9 .   ? -16.720 -38.694 -40.362 0.34 29.50  ? 1391 HOH A O   1 
HETATM 5073 O  O   . HOH N 9 .   ? -24.933 -28.405 -22.386 1.00 52.83  ? 1392 HOH A O   1 
HETATM 5074 O  O   . HOH N 9 .   ? -5.975  -74.487 -12.907 1.00 68.44  ? 1393 HOH A O   1 
HETATM 5075 O  O   . HOH N 9 .   ? -35.692 -47.896 -14.265 1.00 63.97  ? 1394 HOH A O   1 
HETATM 5076 O  O   . HOH N 9 .   ? -18.267 -67.717 -6.511  1.00 26.61  ? 1395 HOH A O   1 
HETATM 5077 O  O   . HOH N 9 .   ? -19.905 -67.937 -4.323  1.00 39.55  ? 1396 HOH A O   1 
HETATM 5078 O  O   . HOH N 9 .   ? -5.723  -64.197 -6.634  1.00 53.91  ? 1397 HOH A O   1 
HETATM 5079 O  O   . HOH N 9 .   ? -26.635 -29.681 -19.048 1.00 73.97  ? 1398 HOH A O   1 
HETATM 5080 O  O   . HOH N 9 .   ? -25.721 -43.621 -33.363 1.00 73.83  ? 1399 HOH A O   1 
HETATM 5081 O  O   . HOH N 9 .   ? -9.680  -24.039 -3.367  1.00 61.75  ? 1400 HOH A O   1 
HETATM 5082 O  O   . HOH N 9 .   ? -44.536 -67.886 -15.646 1.00 67.17  ? 1401 HOH A O   1 
HETATM 5083 O  O   . HOH N 9 .   ? -4.368  -60.901 -10.180 1.00 67.23  ? 1402 HOH A O   1 
HETATM 5084 O  O   . HOH N 9 .   ? -28.108 -55.649 -45.339 1.00 62.39  ? 1403 HOH A O   1 
HETATM 5085 O  O   . HOH N 9 .   ? -1.182  -57.483 -33.475 1.00 78.14  ? 1404 HOH A O   1 
HETATM 5086 O  O   . HOH N 9 .   ? -4.204  -62.508 -8.039  1.00 63.92  ? 1405 HOH A O   1 
HETATM 5087 O  O   . HOH N 9 .   ? -7.557  -63.683 -40.793 1.00 66.68  ? 1406 HOH A O   1 
HETATM 5088 O  O   . HOH N 9 .   ? -42.979 -61.473 -1.456  1.00 63.54  ? 1407 HOH A O   1 
# 
