data_7I2F
# 
_entry.id   7I2F 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   7I2F         pdb_00007i2f 10.2210/pdb7i2f/pdb 
WWPDB D_1001408230 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-02 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.entry_id                        7I2F 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.recvd_initial_deposition_date   2025-03-06 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.SG_entry                        ? 
_pdbx_database_status.pdb_format_compatible           Y 
_pdbx_database_status.methods_development_category    ? 
# 
_pdbx_contact_author.id                 1 
_pdbx_contact_author.email              fr193@cabm.rutgers.edu 
_pdbx_contact_author.name_first         'Francesc Xavier' 
_pdbx_contact_author.name_last          Ruiz 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0457-0030 
_pdbx_contact_author.name_mi            ? 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Aschenbrenner, J.C.' 1  ? 
'Saini, M.'           2  ? 
'Chopra, A.'          3  ? 
'Marples, P.G.'       4  ? 
'Balcomb, B.H.'       5  ? 
'Lithgo, R.M.'        6  ? 
'Fearon, D.'          7  ? 
'von Delft, F.'       8  ? 
'Ruiz, F.X.'          9  ? 
'Arnold, E.'          10 ? 
# 
_citation.id                        primary 
_citation.title                     
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_volume            ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.year                      ? 
_citation.journal_id_ASTM           ? 
_citation.country                   ? 
_citation.journal_id_ISSN           ? 
_citation.journal_id_CSD            0353 
_citation.book_publisher            ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_DOI      ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.identifier_ORCID 
_citation_author.ordinal 
primary 'Aschenbrenner, J.C.' ? 1  
primary 'Saini, M.'           ? 2  
primary 'Chopra, A.'          ? 3  
primary 'Marples, P.G.'       ? 4  
primary 'Balcomb, B.H.'       ? 5  
primary 'Lithgo, R.M.'        ? 6  
primary 'Fearon, D.'          ? 7  
primary 'von Delft, F.'       ? 8  
primary 'Ruiz, F.X.'          ? 9  
primary 'Arnold, E.'          ? 10 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'NS5 RNA-dependent RNA polymerase'                        73890.008 1   ? ? ? ? 
2 non-polymer syn 'ZINC ION'                                                65.409    2   ? ? ? ? 
3 non-polymer syn '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                    195.237   1   ? ? ? ? 
4 non-polymer syn 'DIMETHYL SULFOXIDE'                                      78.133    3   ? ? ? ? 
5 non-polymer syn 'PHOSPHATE ION'                                           94.971    2   ? ? ? ? 
6 non-polymer syn 'DI(HYDROXYETHYL)ETHER'                                   106.120   1   ? ? ? ? 
7 non-polymer syn '[1-(2,2,2-trifluoroethyl)-1H-imidazol-2-yl]acetonitrile' 189.138   1   ? ? ? ? 
8 non-polymer syn 'CHLORIDE ION'                                            35.453    1   ? ? ? ? 
9 water       nat water                                                     18.015    357 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION'                                                ZN  
3 '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                    MES 
4 'DIMETHYL SULFOXIDE'                                      DMS 
5 'PHOSPHATE ION'                                           PO4 
6 'DI(HYDROXYETHYL)ETHER'                                   PEG 
7 '[1-(2,2,2-trifluoroethyl)-1H-imidazol-2-yl]acetonitrile' YXK 
8 'CHLORIDE ION'                                            CL  
9 water                                                     HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PRO n 
1 3   GLY n 
1 4   ILE n 
1 5   GLU n 
1 6   SER n 
1 7   GLU n 
1 8   THR n 
1 9   PRO n 
1 10  ASN n 
1 11  LEU n 
1 12  ASP n 
1 13  ILE n 
1 14  ILE n 
1 15  GLY n 
1 16  LYS n 
1 17  ARG n 
1 18  ILE n 
1 19  GLU n 
1 20  LYS n 
1 21  ILE n 
1 22  LYS n 
1 23  GLN n 
1 24  GLU n 
1 25  HIS n 
1 26  GLU n 
1 27  THR n 
1 28  SER n 
1 29  TRP n 
1 30  HIS n 
1 31  TYR n 
1 32  ASP n 
1 33  GLN n 
1 34  ASP n 
1 35  HIS n 
1 36  PRO n 
1 37  TYR n 
1 38  LYS n 
1 39  THR n 
1 40  TRP n 
1 41  ALA n 
1 42  TYR n 
1 43  HIS n 
1 44  GLY n 
1 45  SER n 
1 46  TYR n 
1 47  GLU n 
1 48  THR n 
1 49  LYS n 
1 50  GLN n 
1 51  THR n 
1 52  GLY n 
1 53  SER n 
1 54  ALA n 
1 55  SER n 
1 56  SER n 
1 57  MET n 
1 58  VAL n 
1 59  ASN n 
1 60  GLY n 
1 61  VAL n 
1 62  VAL n 
1 63  ARG n 
1 64  LEU n 
1 65  LEU n 
1 66  THR n 
1 67  LYS n 
1 68  PRO n 
1 69  TRP n 
1 70  ASP n 
1 71  ILE n 
1 72  ILE n 
1 73  PRO n 
1 74  MET n 
1 75  VAL n 
1 76  THR n 
1 77  GLN n 
1 78  MET n 
1 79  ALA n 
1 80  MET n 
1 81  THR n 
1 82  ASP n 
1 83  THR n 
1 84  THR n 
1 85  PRO n 
1 86  PHE n 
1 87  GLY n 
1 88  GLN n 
1 89  GLN n 
1 90  ARG n 
1 91  VAL n 
1 92  PHE n 
1 93  LYS n 
1 94  GLU n 
1 95  LYS n 
1 96  VAL n 
1 97  ASP n 
1 98  THR n 
1 99  ARG n 
1 100 THR n 
1 101 GLN n 
1 102 GLU n 
1 103 PRO n 
1 104 LYS n 
1 105 GLU n 
1 106 GLY n 
1 107 THR n 
1 108 LYS n 
1 109 LYS n 
1 110 LEU n 
1 111 MET n 
1 112 LYS n 
1 113 ILE n 
1 114 THR n 
1 115 ALA n 
1 116 GLU n 
1 117 TRP n 
1 118 LEU n 
1 119 TRP n 
1 120 LYS n 
1 121 GLU n 
1 122 LEU n 
1 123 GLY n 
1 124 LYS n 
1 125 LYS n 
1 126 LYS n 
1 127 THR n 
1 128 PRO n 
1 129 ARG n 
1 130 MET n 
1 131 CYS n 
1 132 THR n 
1 133 ARG n 
1 134 GLU n 
1 135 GLU n 
1 136 PHE n 
1 137 THR n 
1 138 ARG n 
1 139 LYS n 
1 140 VAL n 
1 141 ARG n 
1 142 SER n 
1 143 ASN n 
1 144 ALA n 
1 145 ALA n 
1 146 LEU n 
1 147 GLY n 
1 148 ALA n 
1 149 ILE n 
1 150 PHE n 
1 151 THR n 
1 152 ASP n 
1 153 GLU n 
1 154 ASN n 
1 155 LYS n 
1 156 TRP n 
1 157 LYS n 
1 158 SER n 
1 159 ALA n 
1 160 ARG n 
1 161 GLU n 
1 162 ALA n 
1 163 VAL n 
1 164 GLU n 
1 165 ASP n 
1 166 SER n 
1 167 GLY n 
1 168 PHE n 
1 169 TRP n 
1 170 GLU n 
1 171 LEU n 
1 172 VAL n 
1 173 ASP n 
1 174 LYS n 
1 175 GLU n 
1 176 ARG n 
1 177 ASN n 
1 178 LEU n 
1 179 HIS n 
1 180 LEU n 
1 181 GLU n 
1 182 GLY n 
1 183 LYS n 
1 184 CYS n 
1 185 GLU n 
1 186 THR n 
1 187 CYS n 
1 188 VAL n 
1 189 TYR n 
1 190 ASN n 
1 191 MET n 
1 192 MET n 
1 193 GLY n 
1 194 LYS n 
1 195 ARG n 
1 196 GLU n 
1 197 LYS n 
1 198 LYS n 
1 199 LEU n 
1 200 GLY n 
1 201 GLU n 
1 202 PHE n 
1 203 GLY n 
1 204 LYS n 
1 205 ALA n 
1 206 LYS n 
1 207 GLY n 
1 208 SER n 
1 209 ARG n 
1 210 ALA n 
1 211 ILE n 
1 212 TRP n 
1 213 TYR n 
1 214 MET n 
1 215 TRP n 
1 216 LEU n 
1 217 GLY n 
1 218 ALA n 
1 219 ARG n 
1 220 PHE n 
1 221 LEU n 
1 222 GLU n 
1 223 PHE n 
1 224 GLU n 
1 225 ALA n 
1 226 LEU n 
1 227 GLY n 
1 228 PHE n 
1 229 LEU n 
1 230 ASN n 
1 231 GLU n 
1 232 ASP n 
1 233 HIS n 
1 234 TRP n 
1 235 PHE n 
1 236 SER n 
1 237 ARG n 
1 238 GLU n 
1 239 ASN n 
1 240 SER n 
1 241 LEU n 
1 242 SER n 
1 243 GLY n 
1 244 VAL n 
1 245 GLU n 
1 246 GLY n 
1 247 GLU n 
1 248 GLY n 
1 249 LEU n 
1 250 HIS n 
1 251 LYS n 
1 252 LEU n 
1 253 GLY n 
1 254 TYR n 
1 255 ILE n 
1 256 LEU n 
1 257 ARG n 
1 258 ASP n 
1 259 VAL n 
1 260 SER n 
1 261 LYS n 
1 262 LYS n 
1 263 GLU n 
1 264 GLY n 
1 265 GLY n 
1 266 ALA n 
1 267 MET n 
1 268 TYR n 
1 269 ALA n 
1 270 ASP n 
1 271 ASP n 
1 272 THR n 
1 273 ALA n 
1 274 GLY n 
1 275 TRP n 
1 276 ASP n 
1 277 THR n 
1 278 ARG n 
1 279 ILE n 
1 280 THR n 
1 281 LEU n 
1 282 GLU n 
1 283 ASP n 
1 284 LEU n 
1 285 LYS n 
1 286 ASN n 
1 287 GLU n 
1 288 GLU n 
1 289 MET n 
1 290 VAL n 
1 291 THR n 
1 292 ASN n 
1 293 HIS n 
1 294 MET n 
1 295 GLU n 
1 296 GLY n 
1 297 GLU n 
1 298 HIS n 
1 299 LYS n 
1 300 LYS n 
1 301 LEU n 
1 302 ALA n 
1 303 GLU n 
1 304 ALA n 
1 305 ILE n 
1 306 PHE n 
1 307 LYS n 
1 308 LEU n 
1 309 THR n 
1 310 TYR n 
1 311 GLN n 
1 312 ASN n 
1 313 LYS n 
1 314 VAL n 
1 315 VAL n 
1 316 ARG n 
1 317 VAL n 
1 318 GLN n 
1 319 ARG n 
1 320 PRO n 
1 321 THR n 
1 322 PRO n 
1 323 ARG n 
1 324 GLY n 
1 325 THR n 
1 326 VAL n 
1 327 MET n 
1 328 ASP n 
1 329 ILE n 
1 330 ILE n 
1 331 SER n 
1 332 ARG n 
1 333 ARG n 
1 334 ASP n 
1 335 GLN n 
1 336 ARG n 
1 337 GLY n 
1 338 SER n 
1 339 GLY n 
1 340 GLN n 
1 341 VAL n 
1 342 VAL n 
1 343 THR n 
1 344 TYR n 
1 345 GLY n 
1 346 LEU n 
1 347 ASN n 
1 348 THR n 
1 349 PHE n 
1 350 THR n 
1 351 ASN n 
1 352 MET n 
1 353 GLU n 
1 354 ALA n 
1 355 GLN n 
1 356 LEU n 
1 357 ILE n 
1 358 ARG n 
1 359 GLN n 
1 360 MET n 
1 361 GLU n 
1 362 GLY n 
1 363 GLU n 
1 364 GLY n 
1 365 VAL n 
1 366 PHE n 
1 367 LYS n 
1 368 SER n 
1 369 ILE n 
1 370 GLN n 
1 371 HIS n 
1 372 LEU n 
1 373 THR n 
1 374 VAL n 
1 375 THR n 
1 376 GLU n 
1 377 GLU n 
1 378 ILE n 
1 379 ALA n 
1 380 VAL n 
1 381 LYS n 
1 382 ASN n 
1 383 TRP n 
1 384 LEU n 
1 385 VAL n 
1 386 ARG n 
1 387 VAL n 
1 388 GLY n 
1 389 ARG n 
1 390 GLU n 
1 391 ARG n 
1 392 LEU n 
1 393 SER n 
1 394 ARG n 
1 395 MET n 
1 396 ALA n 
1 397 ILE n 
1 398 SER n 
1 399 GLY n 
1 400 ASP n 
1 401 ASP n 
1 402 CYS n 
1 403 VAL n 
1 404 VAL n 
1 405 LYS n 
1 406 PRO n 
1 407 LEU n 
1 408 ASP n 
1 409 ASP n 
1 410 ARG n 
1 411 PHE n 
1 412 ALA n 
1 413 SER n 
1 414 ALA n 
1 415 LEU n 
1 416 THR n 
1 417 ALA n 
1 418 LEU n 
1 419 ASN n 
1 420 ASP n 
1 421 MET n 
1 422 GLY n 
1 423 LYS n 
1 424 VAL n 
1 425 ARG n 
1 426 LYS n 
1 427 ASP n 
1 428 ILE n 
1 429 GLN n 
1 430 GLN n 
1 431 TRP n 
1 432 GLU n 
1 433 PRO n 
1 434 SER n 
1 435 ARG n 
1 436 GLY n 
1 437 TRP n 
1 438 ASN n 
1 439 ASP n 
1 440 TRP n 
1 441 THR n 
1 442 GLN n 
1 443 VAL n 
1 444 PRO n 
1 445 PHE n 
1 446 CYS n 
1 447 SER n 
1 448 HIS n 
1 449 HIS n 
1 450 PHE n 
1 451 HIS n 
1 452 GLU n 
1 453 LEU n 
1 454 ILE n 
1 455 MET n 
1 456 LYS n 
1 457 ASP n 
1 458 GLY n 
1 459 ARG n 
1 460 VAL n 
1 461 LEU n 
1 462 VAL n 
1 463 VAL n 
1 464 PRO n 
1 465 CYS n 
1 466 ARG n 
1 467 ASN n 
1 468 GLN n 
1 469 ASP n 
1 470 GLU n 
1 471 LEU n 
1 472 ILE n 
1 473 GLY n 
1 474 ARG n 
1 475 ALA n 
1 476 ARG n 
1 477 ILE n 
1 478 SER n 
1 479 GLN n 
1 480 GLY n 
1 481 ALA n 
1 482 GLY n 
1 483 TRP n 
1 484 SER n 
1 485 LEU n 
1 486 ARG n 
1 487 GLU n 
1 488 THR n 
1 489 ALA n 
1 490 CYS n 
1 491 LEU n 
1 492 GLY n 
1 493 LYS n 
1 494 SER n 
1 495 TYR n 
1 496 ALA n 
1 497 GLN n 
1 498 MET n 
1 499 TRP n 
1 500 SER n 
1 501 LEU n 
1 502 MET n 
1 503 TYR n 
1 504 PHE n 
1 505 HIS n 
1 506 ARG n 
1 507 ARG n 
1 508 ASP n 
1 509 LEU n 
1 510 ARG n 
1 511 LEU n 
1 512 ALA n 
1 513 ALA n 
1 514 ASN n 
1 515 ALA n 
1 516 ILE n 
1 517 CYS n 
1 518 SER n 
1 519 ALA n 
1 520 VAL n 
1 521 PRO n 
1 522 SER n 
1 523 HIS n 
1 524 TRP n 
1 525 VAL n 
1 526 PRO n 
1 527 THR n 
1 528 SER n 
1 529 ARG n 
1 530 THR n 
1 531 THR n 
1 532 TRP n 
1 533 SER n 
1 534 ILE n 
1 535 HIS n 
1 536 ALA n 
1 537 THR n 
1 538 HIS n 
1 539 GLU n 
1 540 TRP n 
1 541 MET n 
1 542 THR n 
1 543 THR n 
1 544 GLU n 
1 545 ASP n 
1 546 MET n 
1 547 LEU n 
1 548 THR n 
1 549 VAL n 
1 550 TRP n 
1 551 ASN n 
1 552 ARG n 
1 553 VAL n 
1 554 TRP n 
1 555 ILE n 
1 556 GLN n 
1 557 GLU n 
1 558 ASN n 
1 559 PRO n 
1 560 TRP n 
1 561 MET n 
1 562 GLU n 
1 563 ASP n 
1 564 LYS n 
1 565 THR n 
1 566 PRO n 
1 567 VAL n 
1 568 GLU n 
1 569 SER n 
1 570 TRP n 
1 571 GLU n 
1 572 GLU n 
1 573 ILE n 
1 574 PRO n 
1 575 TYR n 
1 576 LEU n 
1 577 GLY n 
1 578 LYS n 
1 579 ARG n 
1 580 GLU n 
1 581 ASP n 
1 582 GLN n 
1 583 TRP n 
1 584 CYS n 
1 585 GLY n 
1 586 SER n 
1 587 LEU n 
1 588 ILE n 
1 589 GLY n 
1 590 LEU n 
1 591 THR n 
1 592 SER n 
1 593 ARG n 
1 594 ALA n 
1 595 THR n 
1 596 TRP n 
1 597 ALA n 
1 598 LYS n 
1 599 ASN n 
1 600 ILE n 
1 601 GLN n 
1 602 THR n 
1 603 ALA n 
1 604 ILE n 
1 605 ASN n 
1 606 GLN n 
1 607 VAL n 
1 608 ARG n 
1 609 SER n 
1 610 LEU n 
1 611 ILE n 
1 612 GLY n 
1 613 ASN n 
1 614 GLU n 
1 615 GLU n 
1 616 TYR n 
1 617 THR n 
1 618 ASP n 
1 619 TYR n 
1 620 MET n 
1 621 PRO n 
1 622 SER n 
1 623 MET n 
1 624 LYS n 
1 625 ARG n 
1 626 PHE n 
1 627 ARG n 
1 628 ARG n 
1 629 GLU n 
1 630 GLU n 
1 631 GLU n 
1 632 GLU n 
1 633 ALA n 
1 634 GLY n 
1 635 VAL n 
1 636 LEU n 
1 637 TRP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   637 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'dengue virus type 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     11060 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                                   ? 'C3 H7 N O2'     89.093  
ARG 'L-peptide linking' y ARGININE                                                  ? 'C6 H15 N4 O2 1' 175.209 
ASN 'L-peptide linking' y ASPARAGINE                                                ? 'C4 H8 N2 O3'    132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                           ? 'C4 H7 N O4'     133.103 
CL  non-polymer         . 'CHLORIDE ION'                                            ? 'Cl -1'          35.453  
CYS 'L-peptide linking' y CYSTEINE                                                  ? 'C3 H7 N O2 S'   121.158 
DMS non-polymer         . 'DIMETHYL SULFOXIDE'                                      ? 'C2 H6 O S'      78.133  
GLN 'L-peptide linking' y GLUTAMINE                                                 ? 'C5 H10 N2 O3'   146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                           ? 'C5 H9 N O4'     147.129 
GLY 'peptide linking'   y GLYCINE                                                   ? 'C2 H5 N O2'     75.067  
HIS 'L-peptide linking' y HISTIDINE                                                 ? 'C6 H10 N3 O2 1' 156.162 
HOH non-polymer         . WATER                                                     ? 'H2 O'           18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                                ? 'C6 H13 N O2'    131.173 
LEU 'L-peptide linking' y LEUCINE                                                   ? 'C6 H13 N O2'    131.173 
LYS 'L-peptide linking' y LYSINE                                                    ? 'C6 H15 N2 O2 1' 147.195 
MES non-polymer         . '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                    ? 'C6 H13 N O4 S'  195.237 
MET 'L-peptide linking' y METHIONINE                                                ? 'C5 H11 N O2 S'  149.211 
PEG non-polymer         . 'DI(HYDROXYETHYL)ETHER'                                   ? 'C4 H10 O3'      106.120 
PHE 'L-peptide linking' y PHENYLALANINE                                             ? 'C9 H11 N O2'    165.189 
PO4 non-polymer         . 'PHOSPHATE ION'                                           ? 'O4 P -3'        94.971  
PRO 'L-peptide linking' y PROLINE                                                   ? 'C5 H9 N O2'     115.130 
SER 'L-peptide linking' y SERINE                                                    ? 'C3 H7 N O3'     105.093 
THR 'L-peptide linking' y THREONINE                                                 ? 'C4 H9 N O3'     119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                                ? 'C11 H12 N2 O2'  204.225 
TYR 'L-peptide linking' y TYROSINE                                                  ? 'C9 H11 N O3'    181.189 
VAL 'L-peptide linking' y VALINE                                                    ? 'C5 H11 N O2'    117.146 
YXK non-polymer         . '[1-(2,2,2-trifluoroethyl)-1H-imidazol-2-yl]acetonitrile' ? 'C7 H6 F3 N3'    189.138 
ZN  non-polymer         . 'ZINC ION'                                                ? 'Zn 2'           65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   264 ?   ?   ?   A . n 
A 1 2   PRO 2   265 ?   ?   ?   A . n 
A 1 3   GLY 3   266 ?   ?   ?   A . n 
A 1 4   ILE 4   267 ?   ?   ?   A . n 
A 1 5   GLU 5   268 ?   ?   ?   A . n 
A 1 6   SER 6   269 ?   ?   ?   A . n 
A 1 7   GLU 7   270 ?   ?   ?   A . n 
A 1 8   THR 8   271 ?   ?   ?   A . n 
A 1 9   PRO 9   272 ?   ?   ?   A . n 
A 1 10  ASN 10  273 273 ASN ASN A . n 
A 1 11  LEU 11  274 274 LEU LEU A . n 
A 1 12  ASP 12  275 275 ASP ASP A . n 
A 1 13  ILE 13  276 276 ILE ILE A . n 
A 1 14  ILE 14  277 277 ILE ILE A . n 
A 1 15  GLY 15  278 278 GLY GLY A . n 
A 1 16  LYS 16  279 279 LYS LYS A . n 
A 1 17  ARG 17  280 280 ARG ARG A . n 
A 1 18  ILE 18  281 281 ILE ILE A . n 
A 1 19  GLU 19  282 282 GLU GLU A . n 
A 1 20  LYS 20  283 283 LYS LYS A . n 
A 1 21  ILE 21  284 284 ILE ILE A . n 
A 1 22  LYS 22  285 285 LYS LYS A . n 
A 1 23  GLN 23  286 286 GLN GLN A . n 
A 1 24  GLU 24  287 287 GLU GLU A . n 
A 1 25  HIS 25  288 288 HIS HIS A . n 
A 1 26  GLU 26  289 289 GLU GLU A . n 
A 1 27  THR 27  290 290 THR THR A . n 
A 1 28  SER 28  291 291 SER SER A . n 
A 1 29  TRP 29  292 292 TRP TRP A . n 
A 1 30  HIS 30  293 293 HIS HIS A . n 
A 1 31  TYR 31  294 294 TYR TYR A . n 
A 1 32  ASP 32  295 295 ASP ASP A . n 
A 1 33  GLN 33  296 296 GLN GLN A . n 
A 1 34  ASP 34  297 297 ASP ASP A . n 
A 1 35  HIS 35  298 298 HIS HIS A . n 
A 1 36  PRO 36  299 299 PRO PRO A . n 
A 1 37  TYR 37  300 300 TYR TYR A . n 
A 1 38  LYS 38  301 301 LYS LYS A . n 
A 1 39  THR 39  302 302 THR THR A . n 
A 1 40  TRP 40  303 303 TRP TRP A . n 
A 1 41  ALA 41  304 304 ALA ALA A . n 
A 1 42  TYR 42  305 305 TYR TYR A . n 
A 1 43  HIS 43  306 306 HIS HIS A . n 
A 1 44  GLY 44  307 307 GLY GLY A . n 
A 1 45  SER 45  308 308 SER SER A . n 
A 1 46  TYR 46  309 309 TYR TYR A . n 
A 1 47  GLU 47  310 310 GLU GLU A . n 
A 1 48  THR 48  311 311 THR THR A . n 
A 1 49  LYS 49  312 312 LYS LYS A . n 
A 1 50  GLN 50  313 ?   ?   ?   A . n 
A 1 51  THR 51  314 ?   ?   ?   A . n 
A 1 52  GLY 52  315 ?   ?   ?   A . n 
A 1 53  SER 53  316 ?   ?   ?   A . n 
A 1 54  ALA 54  317 ?   ?   ?   A . n 
A 1 55  SER 55  318 ?   ?   ?   A . n 
A 1 56  SER 56  319 319 SER SER A . n 
A 1 57  MET 57  320 320 MET MET A . n 
A 1 58  VAL 58  321 321 VAL VAL A . n 
A 1 59  ASN 59  322 322 ASN ASN A . n 
A 1 60  GLY 60  323 323 GLY GLY A . n 
A 1 61  VAL 61  324 324 VAL VAL A . n 
A 1 62  VAL 62  325 325 VAL VAL A . n 
A 1 63  ARG 63  326 326 ARG ARG A . n 
A 1 64  LEU 64  327 327 LEU LEU A . n 
A 1 65  LEU 65  328 328 LEU LEU A . n 
A 1 66  THR 66  329 329 THR THR A . n 
A 1 67  LYS 67  330 330 LYS LYS A . n 
A 1 68  PRO 68  331 331 PRO PRO A . n 
A 1 69  TRP 69  332 332 TRP TRP A . n 
A 1 70  ASP 70  333 333 ASP ASP A . n 
A 1 71  ILE 71  334 334 ILE ILE A . n 
A 1 72  ILE 72  335 335 ILE ILE A . n 
A 1 73  PRO 73  336 336 PRO PRO A . n 
A 1 74  MET 74  337 337 MET MET A . n 
A 1 75  VAL 75  338 338 VAL VAL A . n 
A 1 76  THR 76  339 339 THR THR A . n 
A 1 77  GLN 77  340 340 GLN GLN A . n 
A 1 78  MET 78  341 341 MET MET A . n 
A 1 79  ALA 79  342 342 ALA ALA A . n 
A 1 80  MET 80  343 343 MET MET A . n 
A 1 81  THR 81  344 344 THR GLY A . n 
A 1 82  ASP 82  345 ?   ?   ?   A . n 
A 1 83  THR 83  346 ?   ?   ?   A . n 
A 1 84  THR 84  347 ?   ?   ?   A . n 
A 1 85  PRO 85  348 ?   ?   ?   A . n 
A 1 86  PHE 86  349 ?   ?   ?   A . n 
A 1 87  GLY 87  350 ?   ?   ?   A . n 
A 1 88  GLN 88  351 ?   ?   ?   A . n 
A 1 89  GLN 89  352 ?   ?   ?   A . n 
A 1 90  ARG 90  353 ?   ?   ?   A . n 
A 1 91  VAL 91  354 ?   ?   ?   A . n 
A 1 92  PHE 92  355 ?   ?   ?   A . n 
A 1 93  LYS 93  356 ?   ?   ?   A . n 
A 1 94  GLU 94  357 357 GLU GLU A . n 
A 1 95  LYS 95  358 358 LYS LYS A . n 
A 1 96  VAL 96  359 359 VAL VAL A . n 
A 1 97  ASP 97  360 360 ASP ASP A . n 
A 1 98  THR 98  361 361 THR THR A . n 
A 1 99  ARG 99  362 362 ARG ARG A . n 
A 1 100 THR 100 363 363 THR THR A . n 
A 1 101 GLN 101 364 364 GLN GLN A . n 
A 1 102 GLU 102 365 365 GLU GLU A . n 
A 1 103 PRO 103 366 366 PRO PRO A . n 
A 1 104 LYS 104 367 367 LYS LYS A . n 
A 1 105 GLU 105 368 368 GLU GLU A . n 
A 1 106 GLY 106 369 369 GLY GLY A . n 
A 1 107 THR 107 370 370 THR THR A . n 
A 1 108 LYS 108 371 371 LYS LYS A . n 
A 1 109 LYS 109 372 372 LYS LYS A . n 
A 1 110 LEU 110 373 373 LEU LEU A . n 
A 1 111 MET 111 374 374 MET MET A . n 
A 1 112 LYS 112 375 375 LYS LYS A . n 
A 1 113 ILE 113 376 376 ILE ILE A . n 
A 1 114 THR 114 377 377 THR THR A . n 
A 1 115 ALA 115 378 378 ALA ALA A . n 
A 1 116 GLU 116 379 379 GLU GLU A . n 
A 1 117 TRP 117 380 380 TRP TRP A . n 
A 1 118 LEU 118 381 381 LEU LEU A . n 
A 1 119 TRP 119 382 382 TRP TRP A . n 
A 1 120 LYS 120 383 383 LYS LYS A . n 
A 1 121 GLU 121 384 384 GLU GLU A . n 
A 1 122 LEU 122 385 385 LEU LEU A . n 
A 1 123 GLY 123 386 386 GLY GLY A . n 
A 1 124 LYS 124 387 387 LYS LYS A . n 
A 1 125 LYS 125 388 388 LYS LYS A . n 
A 1 126 LYS 126 389 389 LYS LYS A . n 
A 1 127 THR 127 390 390 THR THR A . n 
A 1 128 PRO 128 391 391 PRO PRO A . n 
A 1 129 ARG 129 392 392 ARG ARG A . n 
A 1 130 MET 130 393 393 MET MET A . n 
A 1 131 CYS 131 394 394 CYS CYS A . n 
A 1 132 THR 132 395 395 THR THR A . n 
A 1 133 ARG 133 396 396 ARG ARG A . n 
A 1 134 GLU 134 397 397 GLU GLU A . n 
A 1 135 GLU 135 398 398 GLU GLU A . n 
A 1 136 PHE 136 399 399 PHE PHE A . n 
A 1 137 THR 137 400 400 THR THR A . n 
A 1 138 ARG 138 401 401 ARG ARG A . n 
A 1 139 LYS 139 402 402 LYS LYS A . n 
A 1 140 VAL 140 403 403 VAL VAL A . n 
A 1 141 ARG 141 404 404 ARG ARG A . n 
A 1 142 SER 142 405 405 SER SER A . n 
A 1 143 ASN 143 406 406 ASN ASN A . n 
A 1 144 ALA 144 407 ?   ?   ?   A . n 
A 1 145 ALA 145 408 ?   ?   ?   A . n 
A 1 146 LEU 146 409 ?   ?   ?   A . n 
A 1 147 GLY 147 410 ?   ?   ?   A . n 
A 1 148 ALA 148 411 ?   ?   ?   A . n 
A 1 149 ILE 149 412 ?   ?   ?   A . n 
A 1 150 PHE 150 413 ?   ?   ?   A . n 
A 1 151 THR 151 414 ?   ?   ?   A . n 
A 1 152 ASP 152 415 ?   ?   ?   A . n 
A 1 153 GLU 153 416 ?   ?   ?   A . n 
A 1 154 ASN 154 417 ?   ?   ?   A . n 
A 1 155 LYS 155 418 418 LYS LYS A . n 
A 1 156 TRP 156 419 419 TRP TRP A . n 
A 1 157 LYS 157 420 420 LYS LYS A . n 
A 1 158 SER 158 421 421 SER SER A . n 
A 1 159 ALA 159 422 422 ALA ALA A . n 
A 1 160 ARG 160 423 423 ARG ARG A . n 
A 1 161 GLU 161 424 424 GLU GLU A . n 
A 1 162 ALA 162 425 425 ALA ALA A . n 
A 1 163 VAL 163 426 426 VAL VAL A . n 
A 1 164 GLU 164 427 427 GLU GLU A . n 
A 1 165 ASP 165 428 428 ASP ASP A . n 
A 1 166 SER 166 429 429 SER SER A . n 
A 1 167 GLY 167 430 430 GLY GLY A . n 
A 1 168 PHE 168 431 431 PHE PHE A . n 
A 1 169 TRP 169 432 432 TRP TRP A . n 
A 1 170 GLU 170 433 433 GLU GLU A . n 
A 1 171 LEU 171 434 434 LEU LEU A . n 
A 1 172 VAL 172 435 435 VAL VAL A . n 
A 1 173 ASP 173 436 436 ASP ASP A . n 
A 1 174 LYS 174 437 437 LYS LYS A . n 
A 1 175 GLU 175 438 438 GLU GLU A . n 
A 1 176 ARG 176 439 439 ARG ARG A . n 
A 1 177 ASN 177 440 440 ASN ASN A . n 
A 1 178 LEU 178 441 441 LEU LEU A . n 
A 1 179 HIS 179 442 442 HIS HIS A . n 
A 1 180 LEU 180 443 443 LEU LEU A . n 
A 1 181 GLU 181 444 444 GLU GLU A . n 
A 1 182 GLY 182 445 445 GLY GLY A . n 
A 1 183 LYS 183 446 446 LYS LYS A . n 
A 1 184 CYS 184 447 447 CYS CYS A . n 
A 1 185 GLU 185 448 448 GLU GLU A . n 
A 1 186 THR 186 449 449 THR THR A . n 
A 1 187 CYS 187 450 450 CYS CYS A . n 
A 1 188 VAL 188 451 451 VAL VAL A . n 
A 1 189 TYR 189 452 452 TYR TYR A . n 
A 1 190 ASN 190 453 453 ASN ASN A . n 
A 1 191 MET 191 454 454 MET MET A . n 
A 1 192 MET 192 455 455 MET MET A . n 
A 1 193 GLY 193 456 ?   ?   ?   A . n 
A 1 194 LYS 194 457 ?   ?   ?   A . n 
A 1 195 ARG 195 458 ?   ?   ?   A . n 
A 1 196 GLU 196 459 ?   ?   ?   A . n 
A 1 197 LYS 197 460 ?   ?   ?   A . n 
A 1 198 LYS 198 461 ?   ?   ?   A . n 
A 1 199 LEU 199 462 ?   ?   ?   A . n 
A 1 200 GLY 200 463 ?   ?   ?   A . n 
A 1 201 GLU 201 464 ?   ?   ?   A . n 
A 1 202 PHE 202 465 ?   ?   ?   A . n 
A 1 203 GLY 203 466 ?   ?   ?   A . n 
A 1 204 LYS 204 467 ?   ?   ?   A . n 
A 1 205 ALA 205 468 ?   ?   ?   A . n 
A 1 206 LYS 206 469 ?   ?   ?   A . n 
A 1 207 GLY 207 470 ?   ?   ?   A . n 
A 1 208 SER 208 471 ?   ?   ?   A . n 
A 1 209 ARG 209 472 ?   ?   ?   A . n 
A 1 210 ALA 210 473 473 ALA ALA A . n 
A 1 211 ILE 211 474 474 ILE ILE A . n 
A 1 212 TRP 212 475 475 TRP TRP A . n 
A 1 213 TYR 213 476 476 TYR TYR A . n 
A 1 214 MET 214 477 477 MET MET A . n 
A 1 215 TRP 215 478 478 TRP TRP A . n 
A 1 216 LEU 216 479 479 LEU LEU A . n 
A 1 217 GLY 217 480 480 GLY GLY A . n 
A 1 218 ALA 218 481 481 ALA ALA A . n 
A 1 219 ARG 219 482 482 ARG ARG A . n 
A 1 220 PHE 220 483 483 PHE PHE A . n 
A 1 221 LEU 221 484 484 LEU LEU A . n 
A 1 222 GLU 222 485 485 GLU GLU A . n 
A 1 223 PHE 223 486 486 PHE PHE A . n 
A 1 224 GLU 224 487 487 GLU GLU A . n 
A 1 225 ALA 225 488 488 ALA ALA A . n 
A 1 226 LEU 226 489 489 LEU LEU A . n 
A 1 227 GLY 227 490 490 GLY GLY A . n 
A 1 228 PHE 228 491 491 PHE PHE A . n 
A 1 229 LEU 229 492 492 LEU LEU A . n 
A 1 230 ASN 230 493 493 ASN ASN A . n 
A 1 231 GLU 231 494 494 GLU GLU A . n 
A 1 232 ASP 232 495 495 ASP ASP A . n 
A 1 233 HIS 233 496 496 HIS HIS A . n 
A 1 234 TRP 234 497 497 TRP TRP A . n 
A 1 235 PHE 235 498 498 PHE PHE A . n 
A 1 236 SER 236 499 499 SER SER A . n 
A 1 237 ARG 237 500 500 ARG ARG A . n 
A 1 238 GLU 238 501 501 GLU GLU A . n 
A 1 239 ASN 239 502 502 ASN ASN A . n 
A 1 240 SER 240 503 503 SER SER A . n 
A 1 241 LEU 241 504 504 LEU LEU A . n 
A 1 242 SER 242 505 505 SER SER A . n 
A 1 243 GLY 243 506 506 GLY GLY A . n 
A 1 244 VAL 244 507 507 VAL VAL A . n 
A 1 245 GLU 245 508 508 GLU GLU A . n 
A 1 246 GLY 246 509 509 GLY GLY A . n 
A 1 247 GLU 247 510 510 GLU GLU A . n 
A 1 248 GLY 248 511 511 GLY GLY A . n 
A 1 249 LEU 249 512 512 LEU LEU A . n 
A 1 250 HIS 250 513 513 HIS HIS A . n 
A 1 251 LYS 251 514 514 LYS LYS A . n 
A 1 252 LEU 252 515 515 LEU LEU A . n 
A 1 253 GLY 253 516 516 GLY GLY A . n 
A 1 254 TYR 254 517 517 TYR TYR A . n 
A 1 255 ILE 255 518 518 ILE ILE A . n 
A 1 256 LEU 256 519 519 LEU LEU A . n 
A 1 257 ARG 257 520 520 ARG ARG A . n 
A 1 258 ASP 258 521 521 ASP ASP A . n 
A 1 259 VAL 259 522 522 VAL VAL A . n 
A 1 260 SER 260 523 523 SER SER A . n 
A 1 261 LYS 261 524 524 LYS LYS A . n 
A 1 262 LYS 262 525 525 LYS LYS A . n 
A 1 263 GLU 263 526 526 GLU GLU A . n 
A 1 264 GLY 264 527 527 GLY GLY A . n 
A 1 265 GLY 265 528 528 GLY GLY A . n 
A 1 266 ALA 266 529 529 ALA ALA A . n 
A 1 267 MET 267 530 530 MET MET A . n 
A 1 268 TYR 268 531 531 TYR TYR A . n 
A 1 269 ALA 269 532 532 ALA ALA A . n 
A 1 270 ASP 270 533 533 ASP ASP A . n 
A 1 271 ASP 271 534 534 ASP ASP A . n 
A 1 272 THR 272 535 535 THR THR A . n 
A 1 273 ALA 273 536 536 ALA ALA A . n 
A 1 274 GLY 274 537 537 GLY GLY A . n 
A 1 275 TRP 275 538 538 TRP TRP A . n 
A 1 276 ASP 276 539 539 ASP ASP A . n 
A 1 277 THR 277 540 540 THR THR A . n 
A 1 278 ARG 278 541 541 ARG ARG A . n 
A 1 279 ILE 279 542 542 ILE ILE A . n 
A 1 280 THR 280 543 543 THR THR A . n 
A 1 281 LEU 281 544 544 LEU LEU A . n 
A 1 282 GLU 282 545 545 GLU GLU A . n 
A 1 283 ASP 283 546 546 ASP ASP A . n 
A 1 284 LEU 284 547 547 LEU LEU A . n 
A 1 285 LYS 285 548 548 LYS LYS A . n 
A 1 286 ASN 286 549 549 ASN ASN A . n 
A 1 287 GLU 287 550 550 GLU GLU A . n 
A 1 288 GLU 288 551 551 GLU GLU A . n 
A 1 289 MET 289 552 552 MET MET A . n 
A 1 290 VAL 290 553 553 VAL VAL A . n 
A 1 291 THR 291 554 554 THR THR A . n 
A 1 292 ASN 292 555 555 ASN ASN A . n 
A 1 293 HIS 293 556 556 HIS HIS A . n 
A 1 294 MET 294 557 557 MET MET A . n 
A 1 295 GLU 295 558 558 GLU GLU A . n 
A 1 296 GLY 296 559 559 GLY GLY A . n 
A 1 297 GLU 297 560 560 GLU GLU A . n 
A 1 298 HIS 298 561 561 HIS HIS A . n 
A 1 299 LYS 299 562 562 LYS LYS A . n 
A 1 300 LYS 300 563 563 LYS LYS A . n 
A 1 301 LEU 301 564 564 LEU LEU A . n 
A 1 302 ALA 302 565 565 ALA ALA A . n 
A 1 303 GLU 303 566 566 GLU GLU A . n 
A 1 304 ALA 304 567 567 ALA ALA A . n 
A 1 305 ILE 305 568 568 ILE ILE A . n 
A 1 306 PHE 306 569 569 PHE PHE A . n 
A 1 307 LYS 307 570 570 LYS LYS A . n 
A 1 308 LEU 308 571 571 LEU LEU A . n 
A 1 309 THR 309 572 572 THR THR A . n 
A 1 310 TYR 310 573 573 TYR TYR A . n 
A 1 311 GLN 311 574 574 GLN GLN A . n 
A 1 312 ASN 312 575 575 ASN ASN A . n 
A 1 313 LYS 313 576 576 LYS LYS A . n 
A 1 314 VAL 314 577 577 VAL VAL A . n 
A 1 315 VAL 315 578 578 VAL VAL A . n 
A 1 316 ARG 316 579 579 ARG ARG A . n 
A 1 317 VAL 317 580 580 VAL VAL A . n 
A 1 318 GLN 318 581 581 GLN GLN A . n 
A 1 319 ARG 319 582 582 ARG ARG A . n 
A 1 320 PRO 320 583 583 PRO PRO A . n 
A 1 321 THR 321 584 584 THR THR A . n 
A 1 322 PRO 322 585 ?   ?   ?   A . n 
A 1 323 ARG 323 586 ?   ?   ?   A . n 
A 1 324 GLY 324 587 ?   ?   ?   A . n 
A 1 325 THR 325 588 588 THR THR A . n 
A 1 326 VAL 326 589 589 VAL VAL A . n 
A 1 327 MET 327 590 590 MET MET A . n 
A 1 328 ASP 328 591 591 ASP ASP A . n 
A 1 329 ILE 329 592 592 ILE ILE A . n 
A 1 330 ILE 330 593 593 ILE ILE A . n 
A 1 331 SER 331 594 594 SER SER A . n 
A 1 332 ARG 332 595 595 ARG ARG A . n 
A 1 333 ARG 333 596 596 ARG ARG A . n 
A 1 334 ASP 334 597 597 ASP ASP A . n 
A 1 335 GLN 335 598 598 GLN GLN A . n 
A 1 336 ARG 336 599 599 ARG ARG A . n 
A 1 337 GLY 337 600 600 GLY GLY A . n 
A 1 338 SER 338 601 601 SER SER A . n 
A 1 339 GLY 339 602 602 GLY GLY A . n 
A 1 340 GLN 340 603 603 GLN GLN A . n 
A 1 341 VAL 341 604 604 VAL VAL A . n 
A 1 342 VAL 342 605 605 VAL VAL A . n 
A 1 343 THR 343 606 606 THR THR A . n 
A 1 344 TYR 344 607 607 TYR TYR A . n 
A 1 345 GLY 345 608 608 GLY GLY A . n 
A 1 346 LEU 346 609 609 LEU LEU A . n 
A 1 347 ASN 347 610 610 ASN ASN A . n 
A 1 348 THR 348 611 611 THR THR A . n 
A 1 349 PHE 349 612 612 PHE PHE A . n 
A 1 350 THR 350 613 613 THR THR A . n 
A 1 351 ASN 351 614 614 ASN ASN A . n 
A 1 352 MET 352 615 615 MET MET A . n 
A 1 353 GLU 353 616 616 GLU GLU A . n 
A 1 354 ALA 354 617 617 ALA ALA A . n 
A 1 355 GLN 355 618 618 GLN GLN A . n 
A 1 356 LEU 356 619 619 LEU LEU A . n 
A 1 357 ILE 357 620 620 ILE ILE A . n 
A 1 358 ARG 358 621 621 ARG ARG A . n 
A 1 359 GLN 359 622 622 GLN GLN A . n 
A 1 360 MET 360 623 623 MET MET A . n 
A 1 361 GLU 361 624 624 GLU GLU A . n 
A 1 362 GLY 362 625 625 GLY GLY A . n 
A 1 363 GLU 363 626 626 GLU GLU A . n 
A 1 364 GLY 364 627 627 GLY GLY A . n 
A 1 365 VAL 365 628 628 VAL VAL A . n 
A 1 366 PHE 366 629 629 PHE PHE A . n 
A 1 367 LYS 367 630 630 LYS LYS A . n 
A 1 368 SER 368 631 631 SER SER A . n 
A 1 369 ILE 369 632 632 ILE ILE A . n 
A 1 370 GLN 370 633 633 GLN GLN A . n 
A 1 371 HIS 371 634 634 HIS HIS A . n 
A 1 372 LEU 372 635 635 LEU LEU A . n 
A 1 373 THR 373 636 636 THR THR A . n 
A 1 374 VAL 374 637 637 VAL VAL A . n 
A 1 375 THR 375 638 638 THR THR A . n 
A 1 376 GLU 376 639 639 GLU GLU A . n 
A 1 377 GLU 377 640 640 GLU GLU A . n 
A 1 378 ILE 378 641 641 ILE ILE A . n 
A 1 379 ALA 379 642 642 ALA ALA A . n 
A 1 380 VAL 380 643 643 VAL VAL A . n 
A 1 381 LYS 381 644 644 LYS LYS A . n 
A 1 382 ASN 382 645 645 ASN ASN A . n 
A 1 383 TRP 383 646 646 TRP TRP A . n 
A 1 384 LEU 384 647 647 LEU LEU A . n 
A 1 385 VAL 385 648 648 VAL VAL A . n 
A 1 386 ARG 386 649 649 ARG ARG A . n 
A 1 387 VAL 387 650 650 VAL VAL A . n 
A 1 388 GLY 388 651 651 GLY GLY A . n 
A 1 389 ARG 389 652 652 ARG ARG A . n 
A 1 390 GLU 390 653 653 GLU GLU A . n 
A 1 391 ARG 391 654 654 ARG ARG A . n 
A 1 392 LEU 392 655 655 LEU LEU A . n 
A 1 393 SER 393 656 656 SER SER A . n 
A 1 394 ARG 394 657 657 ARG ARG A . n 
A 1 395 MET 395 658 658 MET MET A . n 
A 1 396 ALA 396 659 659 ALA ALA A . n 
A 1 397 ILE 397 660 660 ILE ILE A . n 
A 1 398 SER 398 661 661 SER SER A . n 
A 1 399 GLY 399 662 662 GLY GLY A . n 
A 1 400 ASP 400 663 663 ASP ASP A . n 
A 1 401 ASP 401 664 664 ASP ASP A . n 
A 1 402 CYS 402 665 665 CYS CYS A . n 
A 1 403 VAL 403 666 666 VAL VAL A . n 
A 1 404 VAL 404 667 667 VAL VAL A . n 
A 1 405 LYS 405 668 668 LYS LYS A . n 
A 1 406 PRO 406 669 669 PRO PRO A . n 
A 1 407 LEU 407 670 670 LEU LEU A . n 
A 1 408 ASP 408 671 671 ASP ASP A . n 
A 1 409 ASP 409 672 672 ASP ASP A . n 
A 1 410 ARG 410 673 673 ARG ARG A . n 
A 1 411 PHE 411 674 674 PHE PHE A . n 
A 1 412 ALA 412 675 675 ALA ALA A . n 
A 1 413 SER 413 676 676 SER SER A . n 
A 1 414 ALA 414 677 677 ALA ALA A . n 
A 1 415 LEU 415 678 678 LEU LEU A . n 
A 1 416 THR 416 679 679 THR THR A . n 
A 1 417 ALA 417 680 680 ALA ALA A . n 
A 1 418 LEU 418 681 681 LEU LEU A . n 
A 1 419 ASN 419 682 682 ASN ASN A . n 
A 1 420 ASP 420 683 683 ASP ASP A . n 
A 1 421 MET 421 684 684 MET MET A . n 
A 1 422 GLY 422 685 685 GLY GLY A . n 
A 1 423 LYS 423 686 686 LYS LYS A . n 
A 1 424 VAL 424 687 687 VAL VAL A . n 
A 1 425 ARG 425 688 688 ARG ARG A . n 
A 1 426 LYS 426 689 689 LYS LYS A . n 
A 1 427 ASP 427 690 690 ASP ASP A . n 
A 1 428 ILE 428 691 691 ILE ILE A . n 
A 1 429 GLN 429 692 692 GLN GLN A . n 
A 1 430 GLN 430 693 693 GLN GLN A . n 
A 1 431 TRP 431 694 694 TRP TRP A . n 
A 1 432 GLU 432 695 695 GLU GLU A . n 
A 1 433 PRO 433 696 696 PRO PRO A . n 
A 1 434 SER 434 697 697 SER SER A . n 
A 1 435 ARG 435 698 698 ARG ARG A . n 
A 1 436 GLY 436 699 699 GLY GLY A . n 
A 1 437 TRP 437 700 700 TRP TRP A . n 
A 1 438 ASN 438 701 701 ASN ASN A . n 
A 1 439 ASP 439 702 702 ASP ASP A . n 
A 1 440 TRP 440 703 703 TRP TRP A . n 
A 1 441 THR 441 704 704 THR THR A . n 
A 1 442 GLN 442 705 705 GLN GLN A . n 
A 1 443 VAL 443 706 706 VAL VAL A . n 
A 1 444 PRO 444 707 707 PRO PRO A . n 
A 1 445 PHE 445 708 708 PHE PHE A . n 
A 1 446 CYS 446 709 709 CYS CYS A . n 
A 1 447 SER 447 710 710 SER SER A . n 
A 1 448 HIS 448 711 711 HIS HIS A . n 
A 1 449 HIS 449 712 712 HIS HIS A . n 
A 1 450 PHE 450 713 713 PHE PHE A . n 
A 1 451 HIS 451 714 714 HIS HIS A . n 
A 1 452 GLU 452 715 715 GLU GLU A . n 
A 1 453 LEU 453 716 716 LEU LEU A . n 
A 1 454 ILE 454 717 717 ILE ILE A . n 
A 1 455 MET 455 718 718 MET MET A . n 
A 1 456 LYS 456 719 719 LYS LYS A . n 
A 1 457 ASP 457 720 720 ASP ASP A . n 
A 1 458 GLY 458 721 721 GLY GLY A . n 
A 1 459 ARG 459 722 722 ARG ARG A . n 
A 1 460 VAL 460 723 723 VAL VAL A . n 
A 1 461 LEU 461 724 724 LEU LEU A . n 
A 1 462 VAL 462 725 725 VAL VAL A . n 
A 1 463 VAL 463 726 726 VAL VAL A . n 
A 1 464 PRO 464 727 727 PRO PRO A . n 
A 1 465 CYS 465 728 728 CYS CYS A . n 
A 1 466 ARG 466 729 729 ARG ARG A . n 
A 1 467 ASN 467 730 730 ASN ASN A . n 
A 1 468 GLN 468 731 731 GLN GLN A . n 
A 1 469 ASP 469 732 732 ASP ASP A . n 
A 1 470 GLU 470 733 733 GLU GLU A . n 
A 1 471 LEU 471 734 734 LEU LEU A . n 
A 1 472 ILE 472 735 735 ILE ILE A . n 
A 1 473 GLY 473 736 736 GLY GLY A . n 
A 1 474 ARG 474 737 737 ARG ARG A . n 
A 1 475 ALA 475 738 738 ALA ALA A . n 
A 1 476 ARG 476 739 739 ARG ARG A . n 
A 1 477 ILE 477 740 740 ILE ILE A . n 
A 1 478 SER 478 741 741 SER SER A . n 
A 1 479 GLN 479 742 742 GLN GLN A . n 
A 1 480 GLY 480 743 743 GLY GLY A . n 
A 1 481 ALA 481 744 744 ALA ALA A . n 
A 1 482 GLY 482 745 745 GLY GLY A . n 
A 1 483 TRP 483 746 746 TRP TRP A . n 
A 1 484 SER 484 747 747 SER SER A . n 
A 1 485 LEU 485 748 748 LEU LEU A . n 
A 1 486 ARG 486 749 749 ARG ARG A . n 
A 1 487 GLU 487 750 750 GLU GLU A . n 
A 1 488 THR 488 751 751 THR THR A . n 
A 1 489 ALA 489 752 752 ALA ALA A . n 
A 1 490 CYS 490 753 753 CYS CYS A . n 
A 1 491 LEU 491 754 754 LEU LEU A . n 
A 1 492 GLY 492 755 755 GLY GLY A . n 
A 1 493 LYS 493 756 756 LYS LYS A . n 
A 1 494 SER 494 757 757 SER SER A . n 
A 1 495 TYR 495 758 758 TYR TYR A . n 
A 1 496 ALA 496 759 759 ALA ALA A . n 
A 1 497 GLN 497 760 760 GLN GLN A . n 
A 1 498 MET 498 761 761 MET MET A . n 
A 1 499 TRP 499 762 762 TRP TRP A . n 
A 1 500 SER 500 763 763 SER SER A . n 
A 1 501 LEU 501 764 764 LEU LEU A . n 
A 1 502 MET 502 765 765 MET MET A . n 
A 1 503 TYR 503 766 766 TYR TYR A . n 
A 1 504 PHE 504 767 767 PHE PHE A . n 
A 1 505 HIS 505 768 768 HIS HIS A . n 
A 1 506 ARG 506 769 769 ARG ARG A . n 
A 1 507 ARG 507 770 770 ARG ARG A . n 
A 1 508 ASP 508 771 771 ASP ASP A . n 
A 1 509 LEU 509 772 772 LEU LEU A . n 
A 1 510 ARG 510 773 773 ARG ARG A . n 
A 1 511 LEU 511 774 774 LEU LEU A . n 
A 1 512 ALA 512 775 775 ALA ALA A . n 
A 1 513 ALA 513 776 776 ALA ALA A . n 
A 1 514 ASN 514 777 777 ASN ASN A . n 
A 1 515 ALA 515 778 778 ALA ALA A . n 
A 1 516 ILE 516 779 779 ILE ILE A . n 
A 1 517 CYS 517 780 780 CYS CYS A . n 
A 1 518 SER 518 781 781 SER SER A . n 
A 1 519 ALA 519 782 782 ALA ALA A . n 
A 1 520 VAL 520 783 783 VAL VAL A . n 
A 1 521 PRO 521 784 784 PRO PRO A . n 
A 1 522 SER 522 785 785 SER SER A . n 
A 1 523 HIS 523 786 786 HIS HIS A . n 
A 1 524 TRP 524 787 787 TRP TRP A . n 
A 1 525 VAL 525 788 788 VAL VAL A . n 
A 1 526 PRO 526 789 789 PRO PRO A . n 
A 1 527 THR 527 790 790 THR THR A . n 
A 1 528 SER 528 791 791 SER SER A . n 
A 1 529 ARG 529 792 ?   ?   ?   A . n 
A 1 530 THR 530 793 ?   ?   ?   A . n 
A 1 531 THR 531 794 ?   ?   ?   A . n 
A 1 532 TRP 532 795 ?   ?   ?   A . n 
A 1 533 SER 533 796 ?   ?   ?   A . n 
A 1 534 ILE 534 797 ?   ?   ?   A . n 
A 1 535 HIS 535 798 ?   ?   ?   A . n 
A 1 536 ALA 536 799 799 ALA ALA A . n 
A 1 537 THR 537 800 800 THR THR A . n 
A 1 538 HIS 538 801 801 HIS HIS A . n 
A 1 539 GLU 539 802 802 GLU GLU A . n 
A 1 540 TRP 540 803 803 TRP TRP A . n 
A 1 541 MET 541 804 804 MET MET A . n 
A 1 542 THR 542 805 805 THR THR A . n 
A 1 543 THR 543 806 806 THR THR A . n 
A 1 544 GLU 544 807 807 GLU GLU A . n 
A 1 545 ASP 545 808 808 ASP ASP A . n 
A 1 546 MET 546 809 809 MET MET A . n 
A 1 547 LEU 547 810 810 LEU LEU A . n 
A 1 548 THR 548 811 811 THR THR A . n 
A 1 549 VAL 549 812 812 VAL VAL A . n 
A 1 550 TRP 550 813 813 TRP TRP A . n 
A 1 551 ASN 551 814 814 ASN ASN A . n 
A 1 552 ARG 552 815 815 ARG ARG A . n 
A 1 553 VAL 553 816 816 VAL VAL A . n 
A 1 554 TRP 554 817 817 TRP TRP A . n 
A 1 555 ILE 555 818 818 ILE ILE A . n 
A 1 556 GLN 556 819 819 GLN GLN A . n 
A 1 557 GLU 557 820 820 GLU GLU A . n 
A 1 558 ASN 558 821 821 ASN ASN A . n 
A 1 559 PRO 559 822 822 PRO PRO A . n 
A 1 560 TRP 560 823 823 TRP TRP A . n 
A 1 561 MET 561 824 824 MET MET A . n 
A 1 562 GLU 562 825 825 GLU GLU A . n 
A 1 563 ASP 563 826 826 ASP ASP A . n 
A 1 564 LYS 564 827 827 LYS LYS A . n 
A 1 565 THR 565 828 828 THR THR A . n 
A 1 566 PRO 566 829 829 PRO PRO A . n 
A 1 567 VAL 567 830 830 VAL VAL A . n 
A 1 568 GLU 568 831 831 GLU GLU A . n 
A 1 569 SER 569 832 832 SER SER A . n 
A 1 570 TRP 570 833 833 TRP TRP A . n 
A 1 571 GLU 571 834 834 GLU GLU A . n 
A 1 572 GLU 572 835 835 GLU GLU A . n 
A 1 573 ILE 573 836 836 ILE ILE A . n 
A 1 574 PRO 574 837 837 PRO PRO A . n 
A 1 575 TYR 575 838 838 TYR TYR A . n 
A 1 576 LEU 576 839 839 LEU LEU A . n 
A 1 577 GLY 577 840 840 GLY GLY A . n 
A 1 578 LYS 578 841 841 LYS LYS A . n 
A 1 579 ARG 579 842 842 ARG ARG A . n 
A 1 580 GLU 580 843 843 GLU GLU A . n 
A 1 581 ASP 581 844 844 ASP ASP A . n 
A 1 582 GLN 582 845 845 GLN GLN A . n 
A 1 583 TRP 583 846 846 TRP TRP A . n 
A 1 584 CYS 584 847 847 CYS CYS A . n 
A 1 585 GLY 585 848 848 GLY GLY A . n 
A 1 586 SER 586 849 849 SER SER A . n 
A 1 587 LEU 587 850 850 LEU LEU A . n 
A 1 588 ILE 588 851 851 ILE ILE A . n 
A 1 589 GLY 589 852 852 GLY GLY A . n 
A 1 590 LEU 590 853 853 LEU LEU A . n 
A 1 591 THR 591 854 854 THR THR A . n 
A 1 592 SER 592 855 855 SER SER A . n 
A 1 593 ARG 593 856 856 ARG ARG A . n 
A 1 594 ALA 594 857 857 ALA ALA A . n 
A 1 595 THR 595 858 858 THR THR A . n 
A 1 596 TRP 596 859 859 TRP TRP A . n 
A 1 597 ALA 597 860 860 ALA ALA A . n 
A 1 598 LYS 598 861 861 LYS LYS A . n 
A 1 599 ASN 599 862 862 ASN ASN A . n 
A 1 600 ILE 600 863 863 ILE ILE A . n 
A 1 601 GLN 601 864 864 GLN GLN A . n 
A 1 602 THR 602 865 865 THR THR A . n 
A 1 603 ALA 603 866 866 ALA ALA A . n 
A 1 604 ILE 604 867 867 ILE ILE A . n 
A 1 605 ASN 605 868 868 ASN ASN A . n 
A 1 606 GLN 606 869 869 GLN GLN A . n 
A 1 607 VAL 607 870 870 VAL VAL A . n 
A 1 608 ARG 608 871 871 ARG ARG A . n 
A 1 609 SER 609 872 872 SER SER A . n 
A 1 610 LEU 610 873 873 LEU LEU A . n 
A 1 611 ILE 611 874 874 ILE ILE A . n 
A 1 612 GLY 612 875 875 GLY GLY A . n 
A 1 613 ASN 613 876 876 ASN ASN A . n 
A 1 614 GLU 614 877 877 GLU GLU A . n 
A 1 615 GLU 615 878 878 GLU GLU A . n 
A 1 616 TYR 616 879 879 TYR TYR A . n 
A 1 617 THR 617 880 880 THR THR A . n 
A 1 618 ASP 618 881 881 ASP ASP A . n 
A 1 619 TYR 619 882 882 TYR TYR A . n 
A 1 620 MET 620 883 883 MET MET A . n 
A 1 621 PRO 621 884 884 PRO PRO A . n 
A 1 622 SER 622 885 885 SER SER A . n 
A 1 623 MET 623 886 886 MET MET A . n 
A 1 624 LYS 624 887 887 LYS LYS A . n 
A 1 625 ARG 625 888 888 ARG ARG A . n 
A 1 626 PHE 626 889 889 PHE PHE A . n 
A 1 627 ARG 627 890 890 ARG ARG A . n 
A 1 628 ARG 628 891 891 ARG ARG A . n 
A 1 629 GLU 629 892 ?   ?   ?   A . n 
A 1 630 GLU 630 893 ?   ?   ?   A . n 
A 1 631 GLU 631 894 ?   ?   ?   A . n 
A 1 632 GLU 632 895 ?   ?   ?   A . n 
A 1 633 ALA 633 896 ?   ?   ?   A . n 
A 1 634 GLY 634 897 ?   ?   ?   A . n 
A 1 635 VAL 635 898 ?   ?   ?   A . n 
A 1 636 LEU 636 899 ?   ?   ?   A . n 
A 1 637 TRP 637 900 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        YXK 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   YXK 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 ZN  1   1001 1001 ZN  ZN  A . 
C 2 ZN  1   1002 1002 ZN  ZN  A . 
D 3 MES 1   1003 1004 MES MES A . 
E 4 DMS 1   1004 1530 DMS DMS A . 
F 4 DMS 1   1005 1601 DMS DMS A . 
G 4 DMS 1   1006 1602 DMS DMS A . 
H 5 PO4 1   1007 1604 PO4 PO4 A . 
I 5 PO4 1   1008 1606 PO4 PO4 A . 
J 6 PEG 1   1009 1607 PEG PEG A . 
K 7 YXK 1   1010 1707 YXK LIG A . 
L 8 CL  1   1011 1    CL  CL  A . 
M 9 HOH 1   1101 90   HOH HOH A . 
M 9 HOH 2   1102 346  HOH HOH A . 
M 9 HOH 3   1103 70   HOH HOH A . 
M 9 HOH 4   1104 176  HOH HOH A . 
M 9 HOH 5   1105 153  HOH HOH A . 
M 9 HOH 6   1106 280  HOH HOH A . 
M 9 HOH 7   1107 6    HOH HOH A . 
M 9 HOH 8   1108 189  HOH HOH A . 
M 9 HOH 9   1109 348  HOH HOH A . 
M 9 HOH 10  1110 254  HOH HOH A . 
M 9 HOH 11  1111 293  HOH HOH A . 
M 9 HOH 12  1112 206  HOH HOH A . 
M 9 HOH 13  1113 230  HOH HOH A . 
M 9 HOH 14  1114 214  HOH HOH A . 
M 9 HOH 15  1115 401  HOH HOH A . 
M 9 HOH 16  1116 209  HOH HOH A . 
M 9 HOH 17  1117 204  HOH HOH A . 
M 9 HOH 18  1118 300  HOH HOH A . 
M 9 HOH 19  1119 249  HOH HOH A . 
M 9 HOH 20  1120 195  HOH HOH A . 
M 9 HOH 21  1121 152  HOH HOH A . 
M 9 HOH 22  1122 166  HOH HOH A . 
M 9 HOH 23  1123 217  HOH HOH A . 
M 9 HOH 24  1124 250  HOH HOH A . 
M 9 HOH 25  1125 52   HOH HOH A . 
M 9 HOH 26  1126 180  HOH HOH A . 
M 9 HOH 27  1127 248  HOH HOH A . 
M 9 HOH 28  1128 341  HOH HOH A . 
M 9 HOH 29  1129 266  HOH HOH A . 
M 9 HOH 30  1130 243  HOH HOH A . 
M 9 HOH 31  1131 247  HOH HOH A . 
M 9 HOH 32  1132 3    HOH HOH A . 
M 9 HOH 33  1133 227  HOH HOH A . 
M 9 HOH 34  1134 288  HOH HOH A . 
M 9 HOH 35  1135 58   HOH HOH A . 
M 9 HOH 36  1136 190  HOH HOH A . 
M 9 HOH 37  1137 177  HOH HOH A . 
M 9 HOH 38  1138 16   HOH HOH A . 
M 9 HOH 39  1139 257  HOH HOH A . 
M 9 HOH 40  1140 237  HOH HOH A . 
M 9 HOH 41  1141 191  HOH HOH A . 
M 9 HOH 42  1142 197  HOH HOH A . 
M 9 HOH 43  1143 461  HOH HOH A . 
M 9 HOH 44  1144 179  HOH HOH A . 
M 9 HOH 45  1145 311  HOH HOH A . 
M 9 HOH 46  1146 205  HOH HOH A . 
M 9 HOH 47  1147 262  HOH HOH A . 
M 9 HOH 48  1148 151  HOH HOH A . 
M 9 HOH 49  1149 312  HOH HOH A . 
M 9 HOH 50  1150 104  HOH HOH A . 
M 9 HOH 51  1151 220  HOH HOH A . 
M 9 HOH 52  1152 186  HOH HOH A . 
M 9 HOH 53  1153 2    HOH HOH A . 
M 9 HOH 54  1154 258  HOH HOH A . 
M 9 HOH 55  1155 268  HOH HOH A . 
M 9 HOH 56  1156 251  HOH HOH A . 
M 9 HOH 57  1157 202  HOH HOH A . 
M 9 HOH 58  1158 165  HOH HOH A . 
M 9 HOH 59  1159 7    HOH HOH A . 
M 9 HOH 60  1160 46   HOH HOH A . 
M 9 HOH 61  1161 210  HOH HOH A . 
M 9 HOH 62  1162 185  HOH HOH A . 
M 9 HOH 63  1163 211  HOH HOH A . 
M 9 HOH 64  1164 256  HOH HOH A . 
M 9 HOH 65  1165 235  HOH HOH A . 
M 9 HOH 66  1166 303  HOH HOH A . 
M 9 HOH 67  1167 219  HOH HOH A . 
M 9 HOH 68  1168 468  HOH HOH A . 
M 9 HOH 69  1169 188  HOH HOH A . 
M 9 HOH 70  1170 240  HOH HOH A . 
M 9 HOH 71  1171 281  HOH HOH A . 
M 9 HOH 72  1172 198  HOH HOH A . 
M 9 HOH 73  1173 278  HOH HOH A . 
M 9 HOH 74  1174 196  HOH HOH A . 
M 9 HOH 75  1175 89   HOH HOH A . 
M 9 HOH 76  1176 178  HOH HOH A . 
M 9 HOH 77  1177 92   HOH HOH A . 
M 9 HOH 78  1178 150  HOH HOH A . 
M 9 HOH 79  1179 34   HOH HOH A . 
M 9 HOH 80  1180 87   HOH HOH A . 
M 9 HOH 81  1181 308  HOH HOH A . 
M 9 HOH 82  1182 234  HOH HOH A . 
M 9 HOH 83  1183 91   HOH HOH A . 
M 9 HOH 84  1184 244  HOH HOH A . 
M 9 HOH 85  1185 320  HOH HOH A . 
M 9 HOH 86  1186 325  HOH HOH A . 
M 9 HOH 87  1187 265  HOH HOH A . 
M 9 HOH 88  1188 236  HOH HOH A . 
M 9 HOH 89  1189 289  HOH HOH A . 
M 9 HOH 90  1190 30   HOH HOH A . 
M 9 HOH 91  1191 306  HOH HOH A . 
M 9 HOH 92  1192 184  HOH HOH A . 
M 9 HOH 93  1193 286  HOH HOH A . 
M 9 HOH 94  1194 213  HOH HOH A . 
M 9 HOH 95  1195 226  HOH HOH A . 
M 9 HOH 96  1196 215  HOH HOH A . 
M 9 HOH 97  1197 292  HOH HOH A . 
M 9 HOH 98  1198 222  HOH HOH A . 
M 9 HOH 99  1199 294  HOH HOH A . 
M 9 HOH 100 1200 295  HOH HOH A . 
M 9 HOH 101 1201 120  HOH HOH A . 
M 9 HOH 102 1202 274  HOH HOH A . 
M 9 HOH 103 1203 331  HOH HOH A . 
M 9 HOH 104 1204 35   HOH HOH A . 
M 9 HOH 105 1205 117  HOH HOH A . 
M 9 HOH 106 1206 298  HOH HOH A . 
M 9 HOH 107 1207 194  HOH HOH A . 
M 9 HOH 108 1208 321  HOH HOH A . 
M 9 HOH 109 1209 144  HOH HOH A . 
M 9 HOH 110 1210 245  HOH HOH A . 
M 9 HOH 111 1211 319  HOH HOH A . 
M 9 HOH 112 1212 333  HOH HOH A . 
M 9 HOH 113 1213 96   HOH HOH A . 
M 9 HOH 114 1214 365  HOH HOH A . 
M 9 HOH 115 1215 446  HOH HOH A . 
M 9 HOH 116 1216 277  HOH HOH A . 
M 9 HOH 117 1217 465  HOH HOH A . 
M 9 HOH 118 1218 318  HOH HOH A . 
M 9 HOH 119 1219 223  HOH HOH A . 
M 9 HOH 120 1220 463  HOH HOH A . 
M 9 HOH 121 1221 339  HOH HOH A . 
M 9 HOH 122 1222 269  HOH HOH A . 
M 9 HOH 123 1223 246  HOH HOH A . 
M 9 HOH 124 1224 458  HOH HOH A . 
M 9 HOH 125 1225 399  HOH HOH A . 
M 9 HOH 126 1226 261  HOH HOH A . 
M 9 HOH 127 1227 241  HOH HOH A . 
M 9 HOH 128 1228 327  HOH HOH A . 
M 9 HOH 129 1229 342  HOH HOH A . 
M 9 HOH 130 1230 143  HOH HOH A . 
M 9 HOH 131 1231 355  HOH HOH A . 
M 9 HOH 132 1232 83   HOH HOH A . 
M 9 HOH 133 1233 290  HOH HOH A . 
M 9 HOH 134 1234 45   HOH HOH A . 
M 9 HOH 135 1235 328  HOH HOH A . 
M 9 HOH 136 1236 309  HOH HOH A . 
M 9 HOH 137 1237 19   HOH HOH A . 
M 9 HOH 138 1238 316  HOH HOH A . 
M 9 HOH 139 1239 187  HOH HOH A . 
M 9 HOH 140 1240 231  HOH HOH A . 
M 9 HOH 141 1241 347  HOH HOH A . 
M 9 HOH 142 1242 216  HOH HOH A . 
M 9 HOH 143 1243 252  HOH HOH A . 
M 9 HOH 144 1244 335  HOH HOH A . 
M 9 HOH 145 1245 285  HOH HOH A . 
M 9 HOH 146 1246 389  HOH HOH A . 
M 9 HOH 147 1247 260  HOH HOH A . 
M 9 HOH 148 1248 367  HOH HOH A . 
M 9 HOH 149 1249 275  HOH HOH A . 
M 9 HOH 150 1250 125  HOH HOH A . 
M 9 HOH 151 1251 388  HOH HOH A . 
M 9 HOH 152 1252 417  HOH HOH A . 
M 9 HOH 153 1253 224  HOH HOH A . 
M 9 HOH 154 1254 270  HOH HOH A . 
M 9 HOH 155 1255 315  HOH HOH A . 
M 9 HOH 156 1256 233  HOH HOH A . 
M 9 HOH 157 1257 238  HOH HOH A . 
M 9 HOH 158 1258 276  HOH HOH A . 
M 9 HOH 159 1259 287  HOH HOH A . 
M 9 HOH 160 1260 182  HOH HOH A . 
M 9 HOH 161 1261 18   HOH HOH A . 
M 9 HOH 162 1262 5    HOH HOH A . 
M 9 HOH 163 1263 368  HOH HOH A . 
M 9 HOH 164 1264 109  HOH HOH A . 
M 9 HOH 165 1265 416  HOH HOH A . 
M 9 HOH 166 1266 350  HOH HOH A . 
M 9 HOH 167 1267 27   HOH HOH A . 
M 9 HOH 168 1268 112  HOH HOH A . 
M 9 HOH 169 1269 304  HOH HOH A . 
M 9 HOH 170 1270 145  HOH HOH A . 
M 9 HOH 171 1271 323  HOH HOH A . 
M 9 HOH 172 1272 26   HOH HOH A . 
M 9 HOH 173 1273 464  HOH HOH A . 
M 9 HOH 174 1274 392  HOH HOH A . 
M 9 HOH 175 1275 345  HOH HOH A . 
M 9 HOH 176 1276 255  HOH HOH A . 
M 9 HOH 177 1277 199  HOH HOH A . 
M 9 HOH 178 1278 279  HOH HOH A . 
M 9 HOH 179 1279 148  HOH HOH A . 
M 9 HOH 180 1280 86   HOH HOH A . 
M 9 HOH 181 1281 377  HOH HOH A . 
M 9 HOH 182 1282 127  HOH HOH A . 
M 9 HOH 183 1283 67   HOH HOH A . 
M 9 HOH 184 1284 366  HOH HOH A . 
M 9 HOH 185 1285 32   HOH HOH A . 
M 9 HOH 186 1286 322  HOH HOH A . 
M 9 HOH 187 1287 313  HOH HOH A . 
M 9 HOH 188 1288 22   HOH HOH A . 
M 9 HOH 189 1289 314  HOH HOH A . 
M 9 HOH 190 1290 239  HOH HOH A . 
M 9 HOH 191 1291 338  HOH HOH A . 
M 9 HOH 192 1292 343  HOH HOH A . 
M 9 HOH 193 1293 384  HOH HOH A . 
M 9 HOH 194 1294 391  HOH HOH A . 
M 9 HOH 195 1295 351  HOH HOH A . 
M 9 HOH 196 1296 175  HOH HOH A . 
M 9 HOH 197 1297 330  HOH HOH A . 
M 9 HOH 198 1298 372  HOH HOH A . 
M 9 HOH 199 1299 284  HOH HOH A . 
M 9 HOH 200 1300 357  HOH HOH A . 
M 9 HOH 201 1301 207  HOH HOH A . 
M 9 HOH 202 1302 271  HOH HOH A . 
M 9 HOH 203 1303 382  HOH HOH A . 
M 9 HOH 204 1304 56   HOH HOH A . 
M 9 HOH 205 1305 394  HOH HOH A . 
M 9 HOH 206 1306 363  HOH HOH A . 
M 9 HOH 207 1307 381  HOH HOH A . 
M 9 HOH 208 1308 356  HOH HOH A . 
M 9 HOH 209 1309 169  HOH HOH A . 
M 9 HOH 210 1310 33   HOH HOH A . 
M 9 HOH 211 1311 297  HOH HOH A . 
M 9 HOH 212 1312 467  HOH HOH A . 
M 9 HOH 213 1313 378  HOH HOH A . 
M 9 HOH 214 1314 354  HOH HOH A . 
M 9 HOH 215 1315 376  HOH HOH A . 
M 9 HOH 216 1316 203  HOH HOH A . 
M 9 HOH 217 1317 282  HOH HOH A . 
M 9 HOH 218 1318 15   HOH HOH A . 
M 9 HOH 219 1319 114  HOH HOH A . 
M 9 HOH 220 1320 380  HOH HOH A . 
M 9 HOH 221 1321 334  HOH HOH A . 
M 9 HOH 222 1322 360  HOH HOH A . 
M 9 HOH 223 1323 218  HOH HOH A . 
M 9 HOH 224 1324 373  HOH HOH A . 
M 9 HOH 225 1325 305  HOH HOH A . 
M 9 HOH 226 1326 402  HOH HOH A . 
M 9 HOH 227 1327 106  HOH HOH A . 
M 9 HOH 228 1328 406  HOH HOH A . 
M 9 HOH 229 1329 38   HOH HOH A . 
M 9 HOH 230 1330 418  HOH HOH A . 
M 9 HOH 231 1331 364  HOH HOH A . 
M 9 HOH 232 1332 386  HOH HOH A . 
M 9 HOH 233 1333 40   HOH HOH A . 
M 9 HOH 234 1334 369  HOH HOH A . 
M 9 HOH 235 1335 98   HOH HOH A . 
M 9 HOH 236 1336 393  HOH HOH A . 
M 9 HOH 237 1337 404  HOH HOH A . 
M 9 HOH 238 1338 81   HOH HOH A . 
M 9 HOH 239 1339 361  HOH HOH A . 
M 9 HOH 240 1340 273  HOH HOH A . 
M 9 HOH 241 1341 42   HOH HOH A . 
M 9 HOH 242 1342 353  HOH HOH A . 
M 9 HOH 243 1343 4    HOH HOH A . 
M 9 HOH 244 1344 14   HOH HOH A . 
M 9 HOH 245 1345 80   HOH HOH A . 
M 9 HOH 246 1346 411  HOH HOH A . 
M 9 HOH 247 1347 379  HOH HOH A . 
M 9 HOH 248 1348 471  HOH HOH A . 
M 9 HOH 249 1349 129  HOH HOH A . 
M 9 HOH 250 1350 201  HOH HOH A . 
M 9 HOH 251 1351 68   HOH HOH A . 
M 9 HOH 252 1352 400  HOH HOH A . 
M 9 HOH 253 1353 161  HOH HOH A . 
M 9 HOH 254 1354 110  HOH HOH A . 
M 9 HOH 255 1355 374  HOH HOH A . 
M 9 HOH 256 1356 50   HOH HOH A . 
M 9 HOH 257 1357 371  HOH HOH A . 
M 9 HOH 258 1358 326  HOH HOH A . 
M 9 HOH 259 1359 409  HOH HOH A . 
M 9 HOH 260 1360 352  HOH HOH A . 
M 9 HOH 261 1361 383  HOH HOH A . 
M 9 HOH 262 1362 340  HOH HOH A . 
M 9 HOH 263 1363 344  HOH HOH A . 
M 9 HOH 264 1364 1    HOH HOH A . 
M 9 HOH 265 1365 138  HOH HOH A . 
M 9 HOH 266 1366 349  HOH HOH A . 
M 9 HOH 267 1367 403  HOH HOH A . 
M 9 HOH 268 1368 398  HOH HOH A . 
M 9 HOH 269 1369 462  HOH HOH A . 
M 9 HOH 270 1370 362  HOH HOH A . 
M 9 HOH 271 1371 136  HOH HOH A . 
M 9 HOH 272 1372 283  HOH HOH A . 
M 9 HOH 273 1373 228  HOH HOH A . 
M 9 HOH 274 1374 422  HOH HOH A . 
M 9 HOH 275 1375 359  HOH HOH A . 
M 9 HOH 276 1376 375  HOH HOH A . 
M 9 HOH 277 1377 99   HOH HOH A . 
M 9 HOH 278 1378 147  HOH HOH A . 
M 9 HOH 279 1379 412  HOH HOH A . 
M 9 HOH 280 1380 132  HOH HOH A . 
M 9 HOH 281 1381 410  HOH HOH A . 
M 9 HOH 282 1382 163  HOH HOH A . 
M 9 HOH 283 1383 407  HOH HOH A . 
M 9 HOH 284 1384 63   HOH HOH A . 
M 9 HOH 285 1385 118  HOH HOH A . 
M 9 HOH 286 1386 427  HOH HOH A . 
M 9 HOH 287 1387 299  HOH HOH A . 
M 9 HOH 288 1388 439  HOH HOH A . 
M 9 HOH 289 1389 253  HOH HOH A . 
M 9 HOH 290 1390 415  HOH HOH A . 
M 9 HOH 291 1391 181  HOH HOH A . 
M 9 HOH 292 1392 390  HOH HOH A . 
M 9 HOH 293 1393 430  HOH HOH A . 
M 9 HOH 294 1394 131  HOH HOH A . 
M 9 HOH 295 1395 324  HOH HOH A . 
M 9 HOH 296 1396 444  HOH HOH A . 
M 9 HOH 297 1397 154  HOH HOH A . 
M 9 HOH 298 1398 437  HOH HOH A . 
M 9 HOH 299 1399 470  HOH HOH A . 
M 9 HOH 300 1400 72   HOH HOH A . 
M 9 HOH 301 1401 436  HOH HOH A . 
M 9 HOH 302 1402 466  HOH HOH A . 
M 9 HOH 303 1403 41   HOH HOH A . 
M 9 HOH 304 1404 469  HOH HOH A . 
M 9 HOH 305 1405 48   HOH HOH A . 
M 9 HOH 306 1406 434  HOH HOH A . 
M 9 HOH 307 1407 208  HOH HOH A . 
M 9 HOH 308 1408 51   HOH HOH A . 
M 9 HOH 309 1409 28   HOH HOH A . 
M 9 HOH 310 1410 414  HOH HOH A . 
M 9 HOH 311 1411 428  HOH HOH A . 
M 9 HOH 312 1412 62   HOH HOH A . 
M 9 HOH 313 1413 21   HOH HOH A . 
M 9 HOH 314 1414 44   HOH HOH A . 
M 9 HOH 315 1415 431  HOH HOH A . 
M 9 HOH 316 1416 329  HOH HOH A . 
M 9 HOH 317 1417 97   HOH HOH A . 
M 9 HOH 318 1418 419  HOH HOH A . 
M 9 HOH 319 1419 43   HOH HOH A . 
M 9 HOH 320 1420 55   HOH HOH A . 
M 9 HOH 321 1421 59   HOH HOH A . 
M 9 HOH 322 1422 438  HOH HOH A . 
M 9 HOH 323 1423 12   HOH HOH A . 
M 9 HOH 324 1424 332  HOH HOH A . 
M 9 HOH 325 1425 137  HOH HOH A . 
M 9 HOH 326 1426 337  HOH HOH A . 
M 9 HOH 327 1427 123  HOH HOH A . 
M 9 HOH 328 1428 424  HOH HOH A . 
M 9 HOH 329 1429 130  HOH HOH A . 
M 9 HOH 330 1430 111  HOH HOH A . 
M 9 HOH 331 1431 61   HOH HOH A . 
M 9 HOH 332 1432 113  HOH HOH A . 
M 9 HOH 333 1433 88   HOH HOH A . 
M 9 HOH 334 1434 426  HOH HOH A . 
M 9 HOH 335 1435 124  HOH HOH A . 
M 9 HOH 336 1436 435  HOH HOH A . 
M 9 HOH 337 1437 103  HOH HOH A . 
M 9 HOH 338 1438 121  HOH HOH A . 
M 9 HOH 339 1439 8    HOH HOH A . 
M 9 HOH 340 1440 78   HOH HOH A . 
M 9 HOH 341 1441 441  HOH HOH A . 
M 9 HOH 342 1442 172  HOH HOH A . 
M 9 HOH 343 1443 126  HOH HOH A . 
M 9 HOH 344 1444 456  HOH HOH A . 
M 9 HOH 345 1445 64   HOH HOH A . 
M 9 HOH 346 1446 443  HOH HOH A . 
M 9 HOH 347 1447 105  HOH HOH A . 
M 9 HOH 348 1448 453  HOH HOH A . 
M 9 HOH 349 1449 445  HOH HOH A . 
M 9 HOH 350 1450 420  HOH HOH A . 
M 9 HOH 351 1451 162  HOH HOH A . 
M 9 HOH 352 1452 447  HOH HOH A . 
M 9 HOH 353 1453 449  HOH HOH A . 
M 9 HOH 354 1454 455  HOH HOH A . 
M 9 HOH 355 1455 9    HOH HOH A . 
M 9 HOH 356 1456 457  HOH HOH A . 
M 9 HOH 357 1457 17   HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A THR 344 ? CB  ? A THR 81 CB  
2 1 Y 1 A THR 344 ? OG1 ? A THR 81 OG1 
3 1 Y 1 A THR 344 ? CG2 ? A THR 81 CG2 
# 
loop_
_software.classification 
_software.name 
_software.version 
_software.citation_id 
_software.pdbx_ordinal 
refinement       REFMAC  5.8.0267 ? 1 
refinement       REFMAC5 .        ? 2 
'data scaling'   Aimless .        ? 3 
phasing          PHASER  .        ? 4 
'data reduction' XDS     .        ? 5 
# 
_cell.entry_id           7I2F 
_cell.length_a           82.380 
_cell.length_b           115.780 
_cell.length_c           147.970 
_cell.angle_alpha        90.00 
_cell.angle_beta         90.00 
_cell.angle_gamma        90.00 
_cell.Z_PDB              8 
_cell.pdbx_unique_axis   ? 
# 
_symmetry.entry_id                         7I2F 
_symmetry.space_group_name_H-M             'I 2 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                23 
# 
_exptl.entry_id          7I2F 
_exptl.method            'X-RAY DIFFRACTION' 
_exptl.crystals_number   1 
# 
_exptl_crystal.id                    1 
_exptl_crystal.density_meas          ? 
_exptl_crystal.density_Matthews      2.39 
_exptl_crystal.density_percent_sol   48.48 
_exptl_crystal.description           ? 
# 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.temp            293.15 
_exptl_crystal_grow.pdbx_details    '350 mM Magnesium chloride, 10% PEG 4000, 100 mM MES, pH 6.5' 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.pdbx_pH_range   ? 
# 
_diffrn.id                     1 
_diffrn.ambient_temp           100 
_diffrn.crystal_id             1 
_diffrn.ambient_temp_details   ? 
# 
_diffrn_detector.detector               PIXEL 
_diffrn_detector.type                   'DECTRIS EIGER2 XE 9M' 
_diffrn_detector.pdbx_collection_date   2023-12-03 
_diffrn_detector.diffrn_id              1 
_diffrn_detector.details                ? 
# 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.92124 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.diffrn_id                   1 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.type                        'DIAMOND BEAMLINE I04-1' 
_diffrn_source.pdbx_wavelength_list        0.92124 
_diffrn_source.pdbx_synchrotron_site       Diamond 
_diffrn_source.pdbx_synchrotron_beamline   I04-1 
_diffrn_source.pdbx_wavelength             ? 
# 
_reflns.entry_id                     7I2F 
_reflns.pdbx_diffrn_id               1 
_reflns.pdbx_ordinal                 1 
_reflns.d_resolution_low             45.59 
_reflns.d_resolution_high            2.05 
_reflns.number_obs                   44692 
_reflns.percent_possible_obs         100.0 
_reflns.pdbx_Rmerge_I_obs            0.384 
_reflns.pdbx_netI_over_sigmaI        7.7 
_reflns.pdbx_redundancy              13.7 
_reflns.pdbx_Rrim_I_all              0.398 
_reflns.pdbx_Rpim_I_all              0.107 
_reflns.pdbx_CC_half                 0.996 
_reflns.pdbx_number_measured_all     613066 
_reflns.pdbx_chi_squared             1.00 
_reflns.observed_criterion_sigma_I   ? 
_reflns.observed_criterion_sigma_F   ? 
_reflns.number_all                   ? 
_reflns.pdbx_Rsym_value              ? 
_reflns.B_iso_Wilson_estimate        ? 
_reflns.pdbx_CC_star                 ? 
# 
_reflns_shell.pdbx_diffrn_id              1 
_reflns_shell.pdbx_ordinal                1 
_reflns_shell.d_res_high                  2.05 
_reflns_shell.d_res_low                   2.10 
_reflns_shell.number_measured_all         46405 
_reflns_shell.number_unique_obs           3240 
_reflns_shell.Rmerge_I_obs                6.459 
_reflns_shell.pdbx_chi_squared            0.95 
_reflns_shell.pdbx_redundancy             14.3 
_reflns_shell.percent_possible_obs        100.0 
_reflns_shell.pdbx_netI_over_sigmaI_obs   0.6 
_reflns_shell.pdbx_Rrim_I_all             6.695 
_reflns_shell.pdbx_Rpim_I_all             1.752 
_reflns_shell.pdbx_CC_half                0.309 
_reflns_shell.percent_possible_all        ? 
_reflns_shell.pdbx_Rsym_value             ? 
_reflns_shell.meanI_over_sigI_obs         ? 
_reflns_shell.number_measured_obs         ? 
_reflns_shell.number_unique_all           ? 
_reflns_shell.pdbx_CC_star                ? 
# 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.entry_id                                 7I2F 
_refine.pdbx_diffrn_id                           1 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     42357 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             45.59 
_refine.ls_d_res_high                            2.05 
_refine.ls_percent_reflns_obs                    99.73 
_refine.ls_R_factor_obs                          0.19647 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       0.19345 
_refine.ls_R_factor_R_free                       0.25069 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 5.1 
_refine.ls_number_reflns_R_free                  2257 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               0.963 
_refine.correlation_coeff_Fo_to_Fc_free          0.935 
_refine.B_iso_mean                               59.880 
_refine.aniso_B[1][1]                            -3.49 
_refine.aniso_B[2][2]                            -0.17 
_refine.aniso_B[3][3]                            3.65 
_refine.aniso_B[1][2]                            -0.00 
_refine.aniso_B[1][3]                            0.00 
_refine.aniso_B[2][3]                            -0.00 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_overall_ESU_R                       0.457 
_refine.pdbx_overall_ESU_R_Free                  0.239 
_refine.overall_SU_ML                            0.279 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             11.895 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.pdbx_number_atoms_protein        4616 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         57 
_refine_hist.number_atoms_solvent             357 
_refine_hist.number_atoms_total               5030 
_refine_hist.d_res_high                       2.05 
_refine_hist.d_res_low                        45.59 
# 
loop_
_refine_ls_restr.type 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.weight 
_refine_ls_restr.number 
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.pdbx_restraint_function 
r_bond_refined_d             0.006  0.014  ? 11246 'X-RAY DIFFRACTION' ? 
r_bond_other_d               0.001  0.015  ? 7787  'X-RAY DIFFRACTION' ? 
r_angle_refined_deg          1.411  1.642  ? 11608 'X-RAY DIFFRACTION' ? 
r_angle_other_deg            1.197  1.593  ? 18038 'X-RAY DIFFRACTION' ? 
r_dihedral_angle_1_deg       6.328  5.000  ? 1074  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_2_deg       30.379 21.113 ? 512   'X-RAY DIFFRACTION' ? 
r_dihedral_angle_3_deg       17.181 15.000 ? 1542  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_4_deg       16.442 15.000 ? 81    'X-RAY DIFFRACTION' ? 
r_chiral_restr               0.059  0.200  ? 1035  'X-RAY DIFFRACTION' ? 
r_gen_planes_refined         0.006  0.020  ? 10076 'X-RAY DIFFRACTION' ? 
r_gen_planes_other           0.001  0.020  ? 2190  'X-RAY DIFFRACTION' ? 
r_nbd_refined                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbd_other                  ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_refined              ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_other                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_refined        ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_other          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_refined          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_other            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_refined       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_other         ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_refined     ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_other       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_refined ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_other   ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_mcbond_it                  2.910  5.915  ? 5339  'X-RAY DIFFRACTION' ? 
r_mcbond_other               2.956  5.924  ? 5162  'X-RAY DIFFRACTION' ? 
r_mcangle_it                 5.305  8.575  ? 5158  'X-RAY DIFFRACTION' ? 
r_mcangle_other              5.304  8.574  ? 5159  'X-RAY DIFFRACTION' ? 
r_scbond_it                  3.214  6.667  ? 5885  'X-RAY DIFFRACTION' ? 
r_scbond_other               3.216  6.673  ? 5875  'X-RAY DIFFRACTION' ? 
r_scangle_it                 ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_scangle_other              5.632  9.497  ? 6418  'X-RAY DIFFRACTION' ? 
r_long_range_B_refined       20.500 62.371 ? 9630  'X-RAY DIFFRACTION' ? 
r_long_range_B_other         20.504 62.189 ? 9489  'X-RAY DIFFRACTION' ? 
r_rigid_bond_restr           ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_free            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_bonded          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.d_res_high                       2.050 
_refine_ls_shell.d_res_low                        2.103 
_refine_ls_shell.number_reflns_R_work             3011 
_refine_ls_shell.R_factor_R_work                  0.439 
_refine_ls_shell.percent_reflns_obs               97.53 
_refine_ls_shell.R_factor_R_free                  0.439 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.number_reflns_R_free             154 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.number_reflns_obs                ? 
# 
_struct.entry_id                  7I2F 
_struct.title                     
;Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z1079168976 (DNV2_NS5A-x0378)
;
_struct.pdbx_model_details        ? 
_struct.pdbx_CASP_flag            ? 
_struct.pdbx_model_type_details   ? 
# 
_struct_keywords.entry_id        7I2F 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
_struct_keywords.text            
;Diamond Light Source, I04-1, READDI, Dengue Virus, crystallographic fragment screening, PanDDA, XChemExplorer, cluster4x, VIRAL PROTEIN
;
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 4 ? 
H N N 5 ? 
I N N 5 ? 
J N N 6 ? 
K N N 7 ? 
L N N 8 ? 
M N N 9 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q91H74_9FLAV 
_struct_ref.pdbx_db_accession          Q91H74 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;GIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAMTD
TTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAREA
VEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLS
GVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRPTP
RGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGDDC
VVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQGAG
WSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPWME
DKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_struct_ref.pdbx_align_begin           2757 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              7I2F 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 3 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 637 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q91H74 
_struct_ref_seq.db_align_beg                  2757 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3391 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       266 
_struct_ref_seq.pdbx_auth_seq_align_end       900 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 7I2F GLY A 1 ? UNP Q91H74 ? ? 'expression tag' 264 1 
1 7I2F PRO A 2 ? UNP Q91H74 ? ? 'expression tag' 265 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 10  ? HIS A 25  ? ASN A 273 HIS A 288 1 ? 16 
HELX_P HELX_P2  AA2 ASN A 59  ? LEU A 65  ? ASN A 322 LEU A 328 1 ? 7  
HELX_P HELX_P3  AA3 THR A 66  ? ILE A 71  ? THR A 329 ILE A 334 5 ? 6  
HELX_P HELX_P4  AA4 ILE A 72  ? GLN A 77  ? ILE A 335 GLN A 340 1 ? 6  
HELX_P HELX_P5  AA5 MET A 78  ? MET A 80  ? MET A 341 MET A 343 5 ? 3  
HELX_P HELX_P6  AA6 LYS A 104 ? LYS A 124 ? LYS A 367 LYS A 387 1 ? 21 
HELX_P HELX_P7  AA7 THR A 132 ? SER A 142 ? THR A 395 SER A 405 1 ? 11 
HELX_P HELX_P8  AA8 SER A 158 ? VAL A 163 ? SER A 421 VAL A 426 1 ? 6  
HELX_P HELX_P9  AA9 ASP A 165 ? GLU A 181 ? ASP A 428 GLU A 444 1 ? 17 
HELX_P HELX_P10 AB1 TRP A 215 ? GLY A 227 ? TRP A 478 GLY A 490 1 ? 13 
HELX_P HELX_P11 AB2 GLY A 227 ? ASP A 232 ? GLY A 490 ASP A 495 1 ? 6  
HELX_P HELX_P12 AB3 SER A 236 ? LEU A 241 ? SER A 499 LEU A 504 1 ? 6  
HELX_P HELX_P13 AB4 GLY A 248 ? LYS A 261 ? GLY A 511 LYS A 524 1 ? 14 
HELX_P HELX_P14 AB5 GLY A 274 ? ILE A 279 ? GLY A 537 ILE A 542 5 ? 6  
HELX_P HELX_P15 AB6 THR A 280 ? MET A 289 ? THR A 543 MET A 552 1 ? 10 
HELX_P HELX_P16 AB7 VAL A 290 ? MET A 294 ? VAL A 553 MET A 557 5 ? 5  
HELX_P HELX_P17 AB8 GLU A 295 ? TYR A 310 ? GLU A 558 TYR A 573 1 ? 16 
HELX_P HELX_P18 AB9 GLY A 339 ? GLU A 363 ? GLY A 602 GLU A 626 1 ? 25 
HELX_P HELX_P19 AC1 THR A 373 ? ARG A 394 ? THR A 636 ARG A 657 1 ? 22 
HELX_P HELX_P20 AC2 ASP A 408 ? ALA A 414 ? ASP A 671 ALA A 677 5 ? 7  
HELX_P HELX_P21 AC3 LEU A 415 ? MET A 421 ? LEU A 678 MET A 684 1 ? 7  
HELX_P HELX_P22 AC4 ASP A 439 ? VAL A 443 ? ASP A 702 VAL A 706 5 ? 5  
HELX_P HELX_P23 AC5 ASN A 467 ? ARG A 476 ? ASN A 730 ARG A 739 1 ? 10 
HELX_P HELX_P24 AC6 SER A 484 ? TYR A 503 ? SER A 747 TYR A 766 1 ? 20 
HELX_P HELX_P25 AC7 ARG A 506 ? VAL A 520 ? ARG A 769 VAL A 783 1 ? 15 
HELX_P HELX_P26 AC8 ASP A 545 ? ILE A 555 ? ASP A 808 ILE A 818 1 ? 11 
HELX_P HELX_P27 AC9 SER A 569 ? ILE A 573 ? SER A 832 ILE A 836 5 ? 5  
HELX_P HELX_P28 AD1 GLY A 577 ? CYS A 584 ? GLY A 840 CYS A 847 1 ? 8  
HELX_P HELX_P29 AD2 LEU A 590 ? ASN A 599 ? LEU A 853 ASN A 862 1 ? 10 
HELX_P HELX_P30 AD3 ASN A 599 ? GLY A 612 ? ASN A 862 GLY A 875 1 ? 14 
HELX_P HELX_P31 AD4 TYR A 619 ? ARG A 627 ? TYR A 882 ARG A 890 5 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A GLU 175 OE1 ? ? ? 1_555 C ZN . ZN ? ? A GLU 438 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.174 ? ? 
metalc2 metalc ? ? A HIS 179 NE2 ? ? ? 1_555 C ZN . ZN ? ? A HIS 442 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.061 ? ? 
metalc3 metalc ? ? A CYS 184 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 447 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.193 ? ? 
metalc4 metalc ? ? A CYS 187 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 450 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.229 ? ? 
metalc5 metalc ? ? A HIS 449 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 712 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.011 ? ? 
metalc6 metalc ? ? A HIS 451 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 714 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.071 ? ? 
metalc7 metalc ? ? A CYS 465 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 728 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.366 ? ? 
metalc8 metalc ? ? A CYS 584 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 847 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.365 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 NE2 ? A HIS 179 ? A HIS 442 ? 1_555 88.9  ? 
2  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 134.1 ? 
3  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 112.2 ? 
4  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 89.6  ? 
5  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 117.4 ? 
6  SG  ? A CYS 184 ? A CYS 447 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 112.7 ? 
7  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 100.8 ? 
8  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 109.3 ? 
9  NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 108.5 ? 
10 NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 101.9 ? 
11 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 117.2 ? 
12 SG  ? A CYS 465 ? A CYS 728 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 117.4 ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 41  ? GLU A 47  ? ALA A 304 GLU A 310 
AA1 2 VAL A 326 ? ARG A 332 ? VAL A 589 ARG A 595 
AA1 3 LYS A 313 ? ARG A 319 ? LYS A 576 ARG A 582 
AA1 4 TYR A 189 ? MET A 191 ? TYR A 452 MET A 454 
AA1 5 TRP A 212 ? TYR A 213 ? TRP A 475 TYR A 476 
AA2 1 MET A 57  ? VAL A 58  ? MET A 320 VAL A 321 
AA2 2 ILE A 477 ? SER A 478 ? ILE A 740 SER A 741 
AA3 1 MET A 395 ? SER A 398 ? MET A 658 SER A 661 
AA3 2 ASP A 401 ? VAL A 404 ? ASP A 664 VAL A 667 
AA4 1 HIS A 449 ? ILE A 454 ? HIS A 712 ILE A 717 
AA4 2 VAL A 460 ? CYS A 465 ? VAL A 723 CYS A 728 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N TYR A 46  ? N TYR A 309 O MET A 327 ? O MET A 590 
AA1 2 3 O ASP A 328 ? O ASP A 591 N VAL A 317 ? N VAL A 580 
AA1 3 4 O VAL A 314 ? O VAL A 577 N TYR A 189 ? N TYR A 452 
AA1 4 5 N ASN A 190 ? N ASN A 453 O TYR A 213 ? O TYR A 476 
AA2 1 2 N MET A 57  ? N MET A 320 O SER A 478 ? O SER A 741 
AA3 1 2 N SER A 398 ? N SER A 661 O ASP A 401 ? O ASP A 664 
AA4 1 2 N LEU A 453 ? N LEU A 716 O LEU A 461 ? O LEU A 724 
# 
_pdbx_entry_details.entry_id                   7I2F 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   OD1 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   ASP 
_pdbx_validate_close_contact.auth_seq_id_1    664 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O4 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   PO4 
_pdbx_validate_close_contact.auth_seq_id_2    1007 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             1.81 
# 
loop_
_pdbx_validate_symm_contact.id 
_pdbx_validate_symm_contact.PDB_model_num 
_pdbx_validate_symm_contact.auth_atom_id_1 
_pdbx_validate_symm_contact.auth_asym_id_1 
_pdbx_validate_symm_contact.auth_comp_id_1 
_pdbx_validate_symm_contact.auth_seq_id_1 
_pdbx_validate_symm_contact.PDB_ins_code_1 
_pdbx_validate_symm_contact.label_alt_id_1 
_pdbx_validate_symm_contact.site_symmetry_1 
_pdbx_validate_symm_contact.auth_atom_id_2 
_pdbx_validate_symm_contact.auth_asym_id_2 
_pdbx_validate_symm_contact.auth_comp_id_2 
_pdbx_validate_symm_contact.auth_seq_id_2 
_pdbx_validate_symm_contact.PDB_ins_code_2 
_pdbx_validate_symm_contact.label_alt_id_2 
_pdbx_validate_symm_contact.site_symmetry_2 
_pdbx_validate_symm_contact.dist 
1 1 O A HOH 1126 ? ? 1_555 O A HOH 1126 ? ? 2_445 1.88 
2 1 O A HOH 1299 ? ? 1_555 O A HOH 1381 ? ? 2_545 1.99 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1  1 THR A 290 ? ? -94.43  32.84   
2  1 SER A 291 ? ? -154.59 -18.50  
3  1 ASP A 360 ? ? -90.89  51.16   
4  1 GLU A 448 ? ? -130.67 -36.32  
5  1 LEU A 504 ? ? 75.13   -38.25  
6  1 GLN A 598 ? ? 77.68   161.66  
7  1 LYS A 630 ? ? -97.26  -60.12  
8  1 ASP A 671 ? ? -160.59 -169.33 
9  1 HIS A 801 ? ? -111.09 67.99   
10 1 ILE A 818 ? ? -117.35 -70.20  
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A MES 1003 ? D MES . 
2 1 A HOH 1163 ? M HOH . 
3 1 A HOH 1240 ? M HOH . 
4 1 A HOH 1422 ? M HOH . 
5 1 A HOH 1424 ? M HOH . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 264 ? A GLY 1   
2  1 Y 1 A PRO 265 ? A PRO 2   
3  1 Y 1 A GLY 266 ? A GLY 3   
4  1 Y 1 A ILE 267 ? A ILE 4   
5  1 Y 1 A GLU 268 ? A GLU 5   
6  1 Y 1 A SER 269 ? A SER 6   
7  1 Y 1 A GLU 270 ? A GLU 7   
8  1 Y 1 A THR 271 ? A THR 8   
9  1 Y 1 A PRO 272 ? A PRO 9   
10 1 Y 1 A GLN 313 ? A GLN 50  
11 1 Y 1 A THR 314 ? A THR 51  
12 1 Y 1 A GLY 315 ? A GLY 52  
13 1 Y 1 A SER 316 ? A SER 53  
14 1 Y 1 A ALA 317 ? A ALA 54  
15 1 Y 1 A SER 318 ? A SER 55  
16 1 Y 1 A ASP 345 ? A ASP 82  
17 1 Y 1 A THR 346 ? A THR 83  
18 1 Y 1 A THR 347 ? A THR 84  
19 1 Y 1 A PRO 348 ? A PRO 85  
20 1 Y 1 A PHE 349 ? A PHE 86  
21 1 Y 1 A GLY 350 ? A GLY 87  
22 1 Y 1 A GLN 351 ? A GLN 88  
23 1 Y 1 A GLN 352 ? A GLN 89  
24 1 Y 1 A ARG 353 ? A ARG 90  
25 1 Y 1 A VAL 354 ? A VAL 91  
26 1 Y 1 A PHE 355 ? A PHE 92  
27 1 Y 1 A LYS 356 ? A LYS 93  
28 1 Y 1 A ALA 407 ? A ALA 144 
29 1 Y 1 A ALA 408 ? A ALA 145 
30 1 Y 1 A LEU 409 ? A LEU 146 
31 1 Y 1 A GLY 410 ? A GLY 147 
32 1 Y 1 A ALA 411 ? A ALA 148 
33 1 Y 1 A ILE 412 ? A ILE 149 
34 1 Y 1 A PHE 413 ? A PHE 150 
35 1 Y 1 A THR 414 ? A THR 151 
36 1 Y 1 A ASP 415 ? A ASP 152 
37 1 Y 1 A GLU 416 ? A GLU 153 
38 1 Y 1 A ASN 417 ? A ASN 154 
39 1 Y 1 A GLY 456 ? A GLY 193 
40 1 Y 1 A LYS 457 ? A LYS 194 
41 1 Y 1 A ARG 458 ? A ARG 195 
42 1 Y 1 A GLU 459 ? A GLU 196 
43 1 Y 1 A LYS 460 ? A LYS 197 
44 1 Y 1 A LYS 461 ? A LYS 198 
45 1 Y 1 A LEU 462 ? A LEU 199 
46 1 Y 1 A GLY 463 ? A GLY 200 
47 1 Y 1 A GLU 464 ? A GLU 201 
48 1 Y 1 A PHE 465 ? A PHE 202 
49 1 Y 1 A GLY 466 ? A GLY 203 
50 1 Y 1 A LYS 467 ? A LYS 204 
51 1 Y 1 A ALA 468 ? A ALA 205 
52 1 Y 1 A LYS 469 ? A LYS 206 
53 1 Y 1 A GLY 470 ? A GLY 207 
54 1 Y 1 A SER 471 ? A SER 208 
55 1 Y 1 A ARG 472 ? A ARG 209 
56 1 Y 1 A PRO 585 ? A PRO 322 
57 1 Y 1 A ARG 586 ? A ARG 323 
58 1 Y 1 A GLY 587 ? A GLY 324 
59 1 Y 1 A ARG 792 ? A ARG 529 
60 1 Y 1 A THR 793 ? A THR 530 
61 1 Y 1 A THR 794 ? A THR 531 
62 1 Y 1 A TRP 795 ? A TRP 532 
63 1 Y 1 A SER 796 ? A SER 533 
64 1 Y 1 A ILE 797 ? A ILE 534 
65 1 Y 1 A HIS 798 ? A HIS 535 
66 1 Y 1 A GLU 892 ? A GLU 629 
67 1 Y 1 A GLU 893 ? A GLU 630 
68 1 Y 1 A GLU 894 ? A GLU 631 
69 1 Y 1 A GLU 895 ? A GLU 632 
70 1 Y 1 A ALA 896 ? A ALA 633 
71 1 Y 1 A GLY 897 ? A GLY 634 
72 1 Y 1 A VAL 898 ? A VAL 635 
73 1 Y 1 A LEU 899 ? A LEU 636 
74 1 Y 1 A TRP 900 ? A TRP 637 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CL  CL   CL N N 74  
CYS N    N  N N 75  
CYS CA   C  N R 76  
CYS C    C  N N 77  
CYS O    O  N N 78  
CYS CB   C  N N 79  
CYS SG   S  N N 80  
CYS OXT  O  N N 81  
CYS H    H  N N 82  
CYS H2   H  N N 83  
CYS HA   H  N N 84  
CYS HB2  H  N N 85  
CYS HB3  H  N N 86  
CYS HG   H  N N 87  
CYS HXT  H  N N 88  
DMS S    S  N N 89  
DMS O    O  N N 90  
DMS C1   C  N N 91  
DMS C2   C  N N 92  
DMS H11  H  N N 93  
DMS H12  H  N N 94  
DMS H13  H  N N 95  
DMS H21  H  N N 96  
DMS H22  H  N N 97  
DMS H23  H  N N 98  
GLN N    N  N N 99  
GLN CA   C  N S 100 
GLN C    C  N N 101 
GLN O    O  N N 102 
GLN CB   C  N N 103 
GLN CG   C  N N 104 
GLN CD   C  N N 105 
GLN OE1  O  N N 106 
GLN NE2  N  N N 107 
GLN OXT  O  N N 108 
GLN H    H  N N 109 
GLN H2   H  N N 110 
GLN HA   H  N N 111 
GLN HB2  H  N N 112 
GLN HB3  H  N N 113 
GLN HG2  H  N N 114 
GLN HG3  H  N N 115 
GLN HE21 H  N N 116 
GLN HE22 H  N N 117 
GLN HXT  H  N N 118 
GLU N    N  N N 119 
GLU CA   C  N S 120 
GLU C    C  N N 121 
GLU O    O  N N 122 
GLU CB   C  N N 123 
GLU CG   C  N N 124 
GLU CD   C  N N 125 
GLU OE1  O  N N 126 
GLU OE2  O  N N 127 
GLU OXT  O  N N 128 
GLU H    H  N N 129 
GLU H2   H  N N 130 
GLU HA   H  N N 131 
GLU HB2  H  N N 132 
GLU HB3  H  N N 133 
GLU HG2  H  N N 134 
GLU HG3  H  N N 135 
GLU HE2  H  N N 136 
GLU HXT  H  N N 137 
GLY N    N  N N 138 
GLY CA   C  N N 139 
GLY C    C  N N 140 
GLY O    O  N N 141 
GLY OXT  O  N N 142 
GLY H    H  N N 143 
GLY H2   H  N N 144 
GLY HA2  H  N N 145 
GLY HA3  H  N N 146 
GLY HXT  H  N N 147 
HIS N    N  N N 148 
HIS CA   C  N S 149 
HIS C    C  N N 150 
HIS O    O  N N 151 
HIS CB   C  N N 152 
HIS CG   C  Y N 153 
HIS ND1  N  Y N 154 
HIS CD2  C  Y N 155 
HIS CE1  C  Y N 156 
HIS NE2  N  Y N 157 
HIS OXT  O  N N 158 
HIS H    H  N N 159 
HIS H2   H  N N 160 
HIS HA   H  N N 161 
HIS HB2  H  N N 162 
HIS HB3  H  N N 163 
HIS HD1  H  N N 164 
HIS HD2  H  N N 165 
HIS HE1  H  N N 166 
HIS HE2  H  N N 167 
HIS HXT  H  N N 168 
HOH O    O  N N 169 
HOH H1   H  N N 170 
HOH H2   H  N N 171 
ILE N    N  N N 172 
ILE CA   C  N S 173 
ILE C    C  N N 174 
ILE O    O  N N 175 
ILE CB   C  N S 176 
ILE CG1  C  N N 177 
ILE CG2  C  N N 178 
ILE CD1  C  N N 179 
ILE OXT  O  N N 180 
ILE H    H  N N 181 
ILE H2   H  N N 182 
ILE HA   H  N N 183 
ILE HB   H  N N 184 
ILE HG12 H  N N 185 
ILE HG13 H  N N 186 
ILE HG21 H  N N 187 
ILE HG22 H  N N 188 
ILE HG23 H  N N 189 
ILE HD11 H  N N 190 
ILE HD12 H  N N 191 
ILE HD13 H  N N 192 
ILE HXT  H  N N 193 
LEU N    N  N N 194 
LEU CA   C  N S 195 
LEU C    C  N N 196 
LEU O    O  N N 197 
LEU CB   C  N N 198 
LEU CG   C  N N 199 
LEU CD1  C  N N 200 
LEU CD2  C  N N 201 
LEU OXT  O  N N 202 
LEU H    H  N N 203 
LEU H2   H  N N 204 
LEU HA   H  N N 205 
LEU HB2  H  N N 206 
LEU HB3  H  N N 207 
LEU HG   H  N N 208 
LEU HD11 H  N N 209 
LEU HD12 H  N N 210 
LEU HD13 H  N N 211 
LEU HD21 H  N N 212 
LEU HD22 H  N N 213 
LEU HD23 H  N N 214 
LEU HXT  H  N N 215 
LYS N    N  N N 216 
LYS CA   C  N S 217 
LYS C    C  N N 218 
LYS O    O  N N 219 
LYS CB   C  N N 220 
LYS CG   C  N N 221 
LYS CD   C  N N 222 
LYS CE   C  N N 223 
LYS NZ   N  N N 224 
LYS OXT  O  N N 225 
LYS H    H  N N 226 
LYS H2   H  N N 227 
LYS HA   H  N N 228 
LYS HB2  H  N N 229 
LYS HB3  H  N N 230 
LYS HG2  H  N N 231 
LYS HG3  H  N N 232 
LYS HD2  H  N N 233 
LYS HD3  H  N N 234 
LYS HE2  H  N N 235 
LYS HE3  H  N N 236 
LYS HZ1  H  N N 237 
LYS HZ2  H  N N 238 
LYS HZ3  H  N N 239 
LYS HXT  H  N N 240 
MES O1   O  N N 241 
MES C2   C  N N 242 
MES C3   C  N N 243 
MES N4   N  N N 244 
MES C5   C  N N 245 
MES C6   C  N N 246 
MES C7   C  N N 247 
MES C8   C  N N 248 
MES S    S  N N 249 
MES O1S  O  N N 250 
MES O2S  O  N N 251 
MES O3S  O  N N 252 
MES H21  H  N N 253 
MES H22  H  N N 254 
MES H31  H  N N 255 
MES H32  H  N N 256 
MES HN4  H  N N 257 
MES H51  H  N N 258 
MES H52  H  N N 259 
MES H61  H  N N 260 
MES H62  H  N N 261 
MES H71  H  N N 262 
MES H72  H  N N 263 
MES H81  H  N N 264 
MES H82  H  N N 265 
MET N    N  N N 266 
MET CA   C  N S 267 
MET C    C  N N 268 
MET O    O  N N 269 
MET CB   C  N N 270 
MET CG   C  N N 271 
MET SD   S  N N 272 
MET CE   C  N N 273 
MET OXT  O  N N 274 
MET H    H  N N 275 
MET H2   H  N N 276 
MET HA   H  N N 277 
MET HB2  H  N N 278 
MET HB3  H  N N 279 
MET HG2  H  N N 280 
MET HG3  H  N N 281 
MET HE1  H  N N 282 
MET HE2  H  N N 283 
MET HE3  H  N N 284 
MET HXT  H  N N 285 
PEG C1   C  N N 286 
PEG O1   O  N N 287 
PEG C2   C  N N 288 
PEG O2   O  N N 289 
PEG C3   C  N N 290 
PEG C4   C  N N 291 
PEG O4   O  N N 292 
PEG H11  H  N N 293 
PEG H12  H  N N 294 
PEG HO1  H  N N 295 
PEG H21  H  N N 296 
PEG H22  H  N N 297 
PEG H31  H  N N 298 
PEG H32  H  N N 299 
PEG H41  H  N N 300 
PEG H42  H  N N 301 
PEG HO4  H  N N 302 
PHE N    N  N N 303 
PHE CA   C  N S 304 
PHE C    C  N N 305 
PHE O    O  N N 306 
PHE CB   C  N N 307 
PHE CG   C  Y N 308 
PHE CD1  C  Y N 309 
PHE CD2  C  Y N 310 
PHE CE1  C  Y N 311 
PHE CE2  C  Y N 312 
PHE CZ   C  Y N 313 
PHE OXT  O  N N 314 
PHE H    H  N N 315 
PHE H2   H  N N 316 
PHE HA   H  N N 317 
PHE HB2  H  N N 318 
PHE HB3  H  N N 319 
PHE HD1  H  N N 320 
PHE HD2  H  N N 321 
PHE HE1  H  N N 322 
PHE HE2  H  N N 323 
PHE HZ   H  N N 324 
PHE HXT  H  N N 325 
PO4 P    P  N N 326 
PO4 O1   O  N N 327 
PO4 O2   O  N N 328 
PO4 O3   O  N N 329 
PO4 O4   O  N N 330 
PRO N    N  N N 331 
PRO CA   C  N S 332 
PRO C    C  N N 333 
PRO O    O  N N 334 
PRO CB   C  N N 335 
PRO CG   C  N N 336 
PRO CD   C  N N 337 
PRO OXT  O  N N 338 
PRO H    H  N N 339 
PRO HA   H  N N 340 
PRO HB2  H  N N 341 
PRO HB3  H  N N 342 
PRO HG2  H  N N 343 
PRO HG3  H  N N 344 
PRO HD2  H  N N 345 
PRO HD3  H  N N 346 
PRO HXT  H  N N 347 
SER N    N  N N 348 
SER CA   C  N S 349 
SER C    C  N N 350 
SER O    O  N N 351 
SER CB   C  N N 352 
SER OG   O  N N 353 
SER OXT  O  N N 354 
SER H    H  N N 355 
SER H2   H  N N 356 
SER HA   H  N N 357 
SER HB2  H  N N 358 
SER HB3  H  N N 359 
SER HG   H  N N 360 
SER HXT  H  N N 361 
THR N    N  N N 362 
THR CA   C  N S 363 
THR C    C  N N 364 
THR O    O  N N 365 
THR CB   C  N R 366 
THR OG1  O  N N 367 
THR CG2  C  N N 368 
THR OXT  O  N N 369 
THR H    H  N N 370 
THR H2   H  N N 371 
THR HA   H  N N 372 
THR HB   H  N N 373 
THR HG1  H  N N 374 
THR HG21 H  N N 375 
THR HG22 H  N N 376 
THR HG23 H  N N 377 
THR HXT  H  N N 378 
TRP N    N  N N 379 
TRP CA   C  N S 380 
TRP C    C  N N 381 
TRP O    O  N N 382 
TRP CB   C  N N 383 
TRP CG   C  Y N 384 
TRP CD1  C  Y N 385 
TRP CD2  C  Y N 386 
TRP NE1  N  Y N 387 
TRP CE2  C  Y N 388 
TRP CE3  C  Y N 389 
TRP CZ2  C  Y N 390 
TRP CZ3  C  Y N 391 
TRP CH2  C  Y N 392 
TRP OXT  O  N N 393 
TRP H    H  N N 394 
TRP H2   H  N N 395 
TRP HA   H  N N 396 
TRP HB2  H  N N 397 
TRP HB3  H  N N 398 
TRP HD1  H  N N 399 
TRP HE1  H  N N 400 
TRP HE3  H  N N 401 
TRP HZ2  H  N N 402 
TRP HZ3  H  N N 403 
TRP HH2  H  N N 404 
TRP HXT  H  N N 405 
TYR N    N  N N 406 
TYR CA   C  N S 407 
TYR C    C  N N 408 
TYR O    O  N N 409 
TYR CB   C  N N 410 
TYR CG   C  Y N 411 
TYR CD1  C  Y N 412 
TYR CD2  C  Y N 413 
TYR CE1  C  Y N 414 
TYR CE2  C  Y N 415 
TYR CZ   C  Y N 416 
TYR OH   O  N N 417 
TYR OXT  O  N N 418 
TYR H    H  N N 419 
TYR H2   H  N N 420 
TYR HA   H  N N 421 
TYR HB2  H  N N 422 
TYR HB3  H  N N 423 
TYR HD1  H  N N 424 
TYR HD2  H  N N 425 
TYR HE1  H  N N 426 
TYR HE2  H  N N 427 
TYR HH   H  N N 428 
TYR HXT  H  N N 429 
VAL N    N  N N 430 
VAL CA   C  N S 431 
VAL C    C  N N 432 
VAL O    O  N N 433 
VAL CB   C  N N 434 
VAL CG1  C  N N 435 
VAL CG2  C  N N 436 
VAL OXT  O  N N 437 
VAL H    H  N N 438 
VAL H2   H  N N 439 
VAL HA   H  N N 440 
VAL HB   H  N N 441 
VAL HG11 H  N N 442 
VAL HG12 H  N N 443 
VAL HG13 H  N N 444 
VAL HG21 H  N N 445 
VAL HG22 H  N N 446 
VAL HG23 H  N N 447 
VAL HXT  H  N N 448 
YXK C10  C  Y N 449 
YXK F01  F  N N 450 
YXK C02  C  N N 451 
YXK F03  F  N N 452 
YXK F04  F  N N 453 
YXK C05  C  N N 454 
YXK N06  N  Y N 455 
YXK C07  C  Y N 456 
YXK C08  C  Y N 457 
YXK N09  N  Y N 458 
YXK C11  C  N N 459 
YXK C12  C  N N 460 
YXK N13  N  N N 461 
YXK H1   H  N N 462 
YXK H2   H  N N 463 
YXK H3   H  N N 464 
YXK H4   H  N N 465 
YXK H5   H  N N 466 
YXK H6   H  N N 467 
ZN  ZN   ZN N N 468 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
DMS S   O    doub N N 83  
DMS S   C1   sing N N 84  
DMS S   C2   sing N N 85  
DMS C1  H11  sing N N 86  
DMS C1  H12  sing N N 87  
DMS C1  H13  sing N N 88  
DMS C2  H21  sing N N 89  
DMS C2  H22  sing N N 90  
DMS C2  H23  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
HIS N   CA   sing N N 138 
HIS N   H    sing N N 139 
HIS N   H2   sing N N 140 
HIS CA  C    sing N N 141 
HIS CA  CB   sing N N 142 
HIS CA  HA   sing N N 143 
HIS C   O    doub N N 144 
HIS C   OXT  sing N N 145 
HIS CB  CG   sing N N 146 
HIS CB  HB2  sing N N 147 
HIS CB  HB3  sing N N 148 
HIS CG  ND1  sing Y N 149 
HIS CG  CD2  doub Y N 150 
HIS ND1 CE1  doub Y N 151 
HIS ND1 HD1  sing N N 152 
HIS CD2 NE2  sing Y N 153 
HIS CD2 HD2  sing N N 154 
HIS CE1 NE2  sing Y N 155 
HIS CE1 HE1  sing N N 156 
HIS NE2 HE2  sing N N 157 
HIS OXT HXT  sing N N 158 
HOH O   H1   sing N N 159 
HOH O   H2   sing N N 160 
ILE N   CA   sing N N 161 
ILE N   H    sing N N 162 
ILE N   H2   sing N N 163 
ILE CA  C    sing N N 164 
ILE CA  CB   sing N N 165 
ILE CA  HA   sing N N 166 
ILE C   O    doub N N 167 
ILE C   OXT  sing N N 168 
ILE CB  CG1  sing N N 169 
ILE CB  CG2  sing N N 170 
ILE CB  HB   sing N N 171 
ILE CG1 CD1  sing N N 172 
ILE CG1 HG12 sing N N 173 
ILE CG1 HG13 sing N N 174 
ILE CG2 HG21 sing N N 175 
ILE CG2 HG22 sing N N 176 
ILE CG2 HG23 sing N N 177 
ILE CD1 HD11 sing N N 178 
ILE CD1 HD12 sing N N 179 
ILE CD1 HD13 sing N N 180 
ILE OXT HXT  sing N N 181 
LEU N   CA   sing N N 182 
LEU N   H    sing N N 183 
LEU N   H2   sing N N 184 
LEU CA  C    sing N N 185 
LEU CA  CB   sing N N 186 
LEU CA  HA   sing N N 187 
LEU C   O    doub N N 188 
LEU C   OXT  sing N N 189 
LEU CB  CG   sing N N 190 
LEU CB  HB2  sing N N 191 
LEU CB  HB3  sing N N 192 
LEU CG  CD1  sing N N 193 
LEU CG  CD2  sing N N 194 
LEU CG  HG   sing N N 195 
LEU CD1 HD11 sing N N 196 
LEU CD1 HD12 sing N N 197 
LEU CD1 HD13 sing N N 198 
LEU CD2 HD21 sing N N 199 
LEU CD2 HD22 sing N N 200 
LEU CD2 HD23 sing N N 201 
LEU OXT HXT  sing N N 202 
LYS N   CA   sing N N 203 
LYS N   H    sing N N 204 
LYS N   H2   sing N N 205 
LYS CA  C    sing N N 206 
LYS CA  CB   sing N N 207 
LYS CA  HA   sing N N 208 
LYS C   O    doub N N 209 
LYS C   OXT  sing N N 210 
LYS CB  CG   sing N N 211 
LYS CB  HB2  sing N N 212 
LYS CB  HB3  sing N N 213 
LYS CG  CD   sing N N 214 
LYS CG  HG2  sing N N 215 
LYS CG  HG3  sing N N 216 
LYS CD  CE   sing N N 217 
LYS CD  HD2  sing N N 218 
LYS CD  HD3  sing N N 219 
LYS CE  NZ   sing N N 220 
LYS CE  HE2  sing N N 221 
LYS CE  HE3  sing N N 222 
LYS NZ  HZ1  sing N N 223 
LYS NZ  HZ2  sing N N 224 
LYS NZ  HZ3  sing N N 225 
LYS OXT HXT  sing N N 226 
MES O1  C2   sing N N 227 
MES O1  C6   sing N N 228 
MES C2  C3   sing N N 229 
MES C2  H21  sing N N 230 
MES C2  H22  sing N N 231 
MES C3  N4   sing N N 232 
MES C3  H31  sing N N 233 
MES C3  H32  sing N N 234 
MES N4  C5   sing N N 235 
MES N4  C7   sing N N 236 
MES N4  HN4  sing N N 237 
MES C5  C6   sing N N 238 
MES C5  H51  sing N N 239 
MES C5  H52  sing N N 240 
MES C6  H61  sing N N 241 
MES C6  H62  sing N N 242 
MES C7  C8   sing N N 243 
MES C7  H71  sing N N 244 
MES C7  H72  sing N N 245 
MES C8  S    sing N N 246 
MES C8  H81  sing N N 247 
MES C8  H82  sing N N 248 
MES S   O1S  doub N N 249 
MES S   O2S  doub N N 250 
MES S   O3S  sing N N 251 
MET N   CA   sing N N 252 
MET N   H    sing N N 253 
MET N   H2   sing N N 254 
MET CA  C    sing N N 255 
MET CA  CB   sing N N 256 
MET CA  HA   sing N N 257 
MET C   O    doub N N 258 
MET C   OXT  sing N N 259 
MET CB  CG   sing N N 260 
MET CB  HB2  sing N N 261 
MET CB  HB3  sing N N 262 
MET CG  SD   sing N N 263 
MET CG  HG2  sing N N 264 
MET CG  HG3  sing N N 265 
MET SD  CE   sing N N 266 
MET CE  HE1  sing N N 267 
MET CE  HE2  sing N N 268 
MET CE  HE3  sing N N 269 
MET OXT HXT  sing N N 270 
PEG C1  O1   sing N N 271 
PEG C1  C2   sing N N 272 
PEG C1  H11  sing N N 273 
PEG C1  H12  sing N N 274 
PEG O1  HO1  sing N N 275 
PEG C2  O2   sing N N 276 
PEG C2  H21  sing N N 277 
PEG C2  H22  sing N N 278 
PEG O2  C3   sing N N 279 
PEG C3  C4   sing N N 280 
PEG C3  H31  sing N N 281 
PEG C3  H32  sing N N 282 
PEG C4  O4   sing N N 283 
PEG C4  H41  sing N N 284 
PEG C4  H42  sing N N 285 
PEG O4  HO4  sing N N 286 
PHE N   CA   sing N N 287 
PHE N   H    sing N N 288 
PHE N   H2   sing N N 289 
PHE CA  C    sing N N 290 
PHE CA  CB   sing N N 291 
PHE CA  HA   sing N N 292 
PHE C   O    doub N N 293 
PHE C   OXT  sing N N 294 
PHE CB  CG   sing N N 295 
PHE CB  HB2  sing N N 296 
PHE CB  HB3  sing N N 297 
PHE CG  CD1  doub Y N 298 
PHE CG  CD2  sing Y N 299 
PHE CD1 CE1  sing Y N 300 
PHE CD1 HD1  sing N N 301 
PHE CD2 CE2  doub Y N 302 
PHE CD2 HD2  sing N N 303 
PHE CE1 CZ   doub Y N 304 
PHE CE1 HE1  sing N N 305 
PHE CE2 CZ   sing Y N 306 
PHE CE2 HE2  sing N N 307 
PHE CZ  HZ   sing N N 308 
PHE OXT HXT  sing N N 309 
PO4 P   O1   doub N N 310 
PO4 P   O2   sing N N 311 
PO4 P   O3   sing N N 312 
PO4 P   O4   sing N N 313 
PRO N   CA   sing N N 314 
PRO N   CD   sing N N 315 
PRO N   H    sing N N 316 
PRO CA  C    sing N N 317 
PRO CA  CB   sing N N 318 
PRO CA  HA   sing N N 319 
PRO C   O    doub N N 320 
PRO C   OXT  sing N N 321 
PRO CB  CG   sing N N 322 
PRO CB  HB2  sing N N 323 
PRO CB  HB3  sing N N 324 
PRO CG  CD   sing N N 325 
PRO CG  HG2  sing N N 326 
PRO CG  HG3  sing N N 327 
PRO CD  HD2  sing N N 328 
PRO CD  HD3  sing N N 329 
PRO OXT HXT  sing N N 330 
SER N   CA   sing N N 331 
SER N   H    sing N N 332 
SER N   H2   sing N N 333 
SER CA  C    sing N N 334 
SER CA  CB   sing N N 335 
SER CA  HA   sing N N 336 
SER C   O    doub N N 337 
SER C   OXT  sing N N 338 
SER CB  OG   sing N N 339 
SER CB  HB2  sing N N 340 
SER CB  HB3  sing N N 341 
SER OG  HG   sing N N 342 
SER OXT HXT  sing N N 343 
THR N   CA   sing N N 344 
THR N   H    sing N N 345 
THR N   H2   sing N N 346 
THR CA  C    sing N N 347 
THR CA  CB   sing N N 348 
THR CA  HA   sing N N 349 
THR C   O    doub N N 350 
THR C   OXT  sing N N 351 
THR CB  OG1  sing N N 352 
THR CB  CG2  sing N N 353 
THR CB  HB   sing N N 354 
THR OG1 HG1  sing N N 355 
THR CG2 HG21 sing N N 356 
THR CG2 HG22 sing N N 357 
THR CG2 HG23 sing N N 358 
THR OXT HXT  sing N N 359 
TRP N   CA   sing N N 360 
TRP N   H    sing N N 361 
TRP N   H2   sing N N 362 
TRP CA  C    sing N N 363 
TRP CA  CB   sing N N 364 
TRP CA  HA   sing N N 365 
TRP C   O    doub N N 366 
TRP C   OXT  sing N N 367 
TRP CB  CG   sing N N 368 
TRP CB  HB2  sing N N 369 
TRP CB  HB3  sing N N 370 
TRP CG  CD1  doub Y N 371 
TRP CG  CD2  sing Y N 372 
TRP CD1 NE1  sing Y N 373 
TRP CD1 HD1  sing N N 374 
TRP CD2 CE2  doub Y N 375 
TRP CD2 CE3  sing Y N 376 
TRP NE1 CE2  sing Y N 377 
TRP NE1 HE1  sing N N 378 
TRP CE2 CZ2  sing Y N 379 
TRP CE3 CZ3  doub Y N 380 
TRP CE3 HE3  sing N N 381 
TRP CZ2 CH2  doub Y N 382 
TRP CZ2 HZ2  sing N N 383 
TRP CZ3 CH2  sing Y N 384 
TRP CZ3 HZ3  sing N N 385 
TRP CH2 HH2  sing N N 386 
TRP OXT HXT  sing N N 387 
TYR N   CA   sing N N 388 
TYR N   H    sing N N 389 
TYR N   H2   sing N N 390 
TYR CA  C    sing N N 391 
TYR CA  CB   sing N N 392 
TYR CA  HA   sing N N 393 
TYR C   O    doub N N 394 
TYR C   OXT  sing N N 395 
TYR CB  CG   sing N N 396 
TYR CB  HB2  sing N N 397 
TYR CB  HB3  sing N N 398 
TYR CG  CD1  doub Y N 399 
TYR CG  CD2  sing Y N 400 
TYR CD1 CE1  sing Y N 401 
TYR CD1 HD1  sing N N 402 
TYR CD2 CE2  doub Y N 403 
TYR CD2 HD2  sing N N 404 
TYR CE1 CZ   doub Y N 405 
TYR CE1 HE1  sing N N 406 
TYR CE2 CZ   sing Y N 407 
TYR CE2 HE2  sing N N 408 
TYR CZ  OH   sing N N 409 
TYR OH  HH   sing N N 410 
TYR OXT HXT  sing N N 411 
VAL N   CA   sing N N 412 
VAL N   H    sing N N 413 
VAL N   H2   sing N N 414 
VAL CA  C    sing N N 415 
VAL CA  CB   sing N N 416 
VAL CA  HA   sing N N 417 
VAL C   O    doub N N 418 
VAL C   OXT  sing N N 419 
VAL CB  CG1  sing N N 420 
VAL CB  CG2  sing N N 421 
VAL CB  HB   sing N N 422 
VAL CG1 HG11 sing N N 423 
VAL CG1 HG12 sing N N 424 
VAL CG1 HG13 sing N N 425 
VAL CG2 HG21 sing N N 426 
VAL CG2 HG22 sing N N 427 
VAL CG2 HG23 sing N N 428 
VAL OXT HXT  sing N N 429 
YXK F04 C02  sing N N 430 
YXK F03 C02  sing N N 431 
YXK C02 C05  sing N N 432 
YXK C02 F01  sing N N 433 
YXK C05 N06  sing N N 434 
YXK C07 N06  sing Y N 435 
YXK C07 C08  doub Y N 436 
YXK N06 C10  sing Y N 437 
YXK C08 N09  sing Y N 438 
YXK C10 C11  sing N N 439 
YXK C10 N09  doub Y N 440 
YXK C11 C12  sing N N 441 
YXK C12 N13  trip N N 442 
YXK C05 H1   sing N N 443 
YXK C05 H2   sing N N 444 
YXK C07 H3   sing N N 445 
YXK C08 H4   sing N N 446 
YXK C11 H5   sing N N 447 
YXK C11 H6   sing N N 448 
# 
_pdbx_audit_support.ordinal                1 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)' 
_pdbx_audit_support.grant_number           U19AI171292 
_pdbx_audit_support.country                'United States' 
# 
_pdbx_deposit_group.group_id            G_1002341 
_pdbx_deposit_group.group_description   
'Crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_title         
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_type          'changed state' 
# 
_atom_sites.entry_id                    7I2F 
_atom_sites.fract_transf_matrix[1][1]   0.012139 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.008637 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006758 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
# 
loop_
_atom_type.symbol 
C  
CL 
F  
N  
O  
P  
S  
ZN 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ASN A 1 10  ? -13.934 -5.909  -12.554 1.00 113.41 ? 273  ASN A N   1 
ATOM   2    C  CA  . ASN A 1 10  ? -13.792 -6.971  -11.525 1.00 105.89 ? 273  ASN A CA  1 
ATOM   3    C  C   . ASN A 1 10  ? -14.842 -6.757  -10.439 1.00 96.23  ? 273  ASN A C   1 
ATOM   4    O  O   . ASN A 1 10  ? -15.931 -7.334  -10.566 1.00 88.36  ? 273  ASN A O   1 
ATOM   5    C  CB  . ASN A 1 10  ? -12.383 -6.995  -10.932 1.00 105.97 ? 273  ASN A CB  1 
ATOM   6    C  CG  . ASN A 1 10  ? -12.104 -8.229  -10.100 1.00 108.43 ? 273  ASN A CG  1 
ATOM   7    O  OD1 . ASN A 1 10  ? -12.533 -9.327  -10.447 1.00 104.47 ? 273  ASN A OD1 1 
ATOM   8    N  ND2 . ASN A 1 10  ? -11.372 -8.059  -9.011  1.00 98.20  ? 273  ASN A ND2 1 
ATOM   9    N  N   . LEU A 1 11  ? -14.529 -5.941  -9.428  1.00 97.39  ? 274  LEU A N   1 
ATOM   10   C  CA  . LEU A 1 11  ? -15.456 -5.761  -8.280  1.00 86.65  ? 274  LEU A CA  1 
ATOM   11   C  C   . LEU A 1 11  ? -16.790 -5.236  -8.797  1.00 76.61  ? 274  LEU A C   1 
ATOM   12   O  O   . LEU A 1 11  ? -17.828 -5.608  -8.235  1.00 69.53  ? 274  LEU A O   1 
ATOM   13   C  CB  . LEU A 1 11  ? -14.825 -4.803  -7.269  1.00 90.04  ? 274  LEU A CB  1 
ATOM   14   C  CG  . LEU A 1 11  ? -15.549 -4.728  -5.927  1.00 95.47  ? 274  LEU A CG  1 
ATOM   15   C  CD1 . LEU A 1 11  ? -15.769 -6.120  -5.358  1.00 98.19  ? 274  LEU A CD1 1 
ATOM   16   C  CD2 . LEU A 1 11  ? -14.777 -3.863  -4.943  1.00 86.41  ? 274  LEU A CD2 1 
ATOM   17   N  N   . ASP A 1 12  ? -16.751 -4.427  -9.848  1.00 68.11  ? 275  ASP A N   1 
ATOM   18   C  CA  . ASP A 1 12  ? -18.021 -3.971  -10.457 1.00 82.25  ? 275  ASP A CA  1 
ATOM   19   C  C   . ASP A 1 12  ? -18.825 -5.201  -10.884 1.00 81.98  ? 275  ASP A C   1 
ATOM   20   O  O   . ASP A 1 12  ? -20.051 -5.189  -10.684 1.00 81.55  ? 275  ASP A O   1 
ATOM   21   C  CB  . ASP A 1 12  ? -17.747 -3.019  -11.622 1.00 86.86  ? 275  ASP A CB  1 
ATOM   22   C  CG  . ASP A 1 12  ? -16.798 -3.591  -12.657 1.00 96.93  ? 275  ASP A CG  1 
ATOM   23   O  OD1 . ASP A 1 12  ? -16.051 -4.525  -12.310 1.00 96.60  ? 275  ASP A OD1 1 
ATOM   24   O  OD2 . ASP A 1 12  ? -16.822 -3.105  -13.803 1.00 103.41 ? 275  ASP A OD2 1 
ATOM   25   N  N   . ILE A 1 13  ? -18.154 -6.237  -11.398 1.00 75.98  ? 276  ILE A N   1 
ATOM   26   C  CA  . ILE A 1 13  ? -18.870 -7.431  -11.940 1.00 64.71  ? 276  ILE A CA  1 
ATOM   27   C  C   . ILE A 1 13  ? -19.106 -8.464  -10.839 1.00 64.00  ? 276  ILE A C   1 
ATOM   28   O  O   . ILE A 1 13  ? -20.081 -9.217  -10.953 1.00 58.69  ? 276  ILE A O   1 
ATOM   29   C  CB  . ILE A 1 13  ? -18.068 -8.010  -13.119 1.00 66.69  ? 276  ILE A CB  1 
ATOM   30   C  CG1 . ILE A 1 13  ? -17.936 -6.989  -14.252 1.00 59.67  ? 276  ILE A CG1 1 
ATOM   31   C  CG2 . ILE A 1 13  ? -18.669 -9.319  -13.604 1.00 68.08  ? 276  ILE A CG2 1 
ATOM   32   C  CD1 . ILE A 1 13  ? -17.166 -7.489  -15.445 1.00 57.16  ? 276  ILE A CD1 1 
ATOM   33   N  N   . ILE A 1 14  ? -18.283 -8.459  -9.793  1.00 61.89  ? 277  ILE A N   1 
ATOM   34   C  CA  . ILE A 1 14  ? -18.386 -9.509  -8.739  1.00 73.08  ? 277  ILE A CA  1 
ATOM   35   C  C   . ILE A 1 14  ? -19.085 -8.961  -7.493  1.00 70.95  ? 277  ILE A C   1 
ATOM   36   O  O   . ILE A 1 14  ? -19.744 -9.749  -6.805  1.00 67.25  ? 277  ILE A O   1 
ATOM   37   C  CB  . ILE A 1 14  ? -16.981 -10.054 -8.419  1.00 79.36  ? 277  ILE A CB  1 
ATOM   38   C  CG1 . ILE A 1 14  ? -16.083 -8.991  -7.784  1.00 76.73  ? 277  ILE A CG1 1 
ATOM   39   C  CG2 . ILE A 1 14  ? -16.346 -10.654 -9.663  1.00 81.21  ? 277  ILE A CG2 1 
ATOM   40   C  CD1 . ILE A 1 14  ? -14.677 -9.464  -7.515  1.00 81.54  ? 277  ILE A CD1 1 
ATOM   41   N  N   . GLY A 1 15  ? -18.943 -7.665  -7.220  1.00 84.89  ? 278  GLY A N   1 
ATOM   42   C  CA  . GLY A 1 15  ? -19.529 -7.042  -6.015  1.00 81.40  ? 278  GLY A CA  1 
ATOM   43   C  C   . GLY A 1 15  ? -20.955 -7.475  -5.744  1.00 79.03  ? 278  GLY A C   1 
ATOM   44   O  O   . GLY A 1 15  ? -21.193 -8.072  -4.687  1.00 76.97  ? 278  GLY A O   1 
ATOM   45   N  N   . LYS A 1 16  ? -21.873 -7.178  -6.659  1.00 73.06  ? 279  LYS A N   1 
ATOM   46   C  CA  . LYS A 1 16  ? -23.297 -7.487  -6.393  1.00 76.36  ? 279  LYS A CA  1 
ATOM   47   C  C   . LYS A 1 16  ? -23.377 -8.920  -5.880  1.00 70.65  ? 279  LYS A C   1 
ATOM   48   O  O   . LYS A 1 16  ? -24.039 -9.149  -4.862  1.00 60.69  ? 279  LYS A O   1 
ATOM   49   C  CB  . LYS A 1 16  ? -24.131 -7.300  -7.661  1.00 79.62  ? 279  LYS A CB  1 
ATOM   50   C  CG  . LYS A 1 16  ? -25.632 -7.473  -7.484  1.00 84.50  ? 279  LYS A CG  1 
ATOM   51   C  CD  . LYS A 1 16  ? -26.431 -6.951  -8.656  1.00 93.07  ? 279  LYS A CD  1 
ATOM   52   C  CE  . LYS A 1 16  ? -27.925 -7.004  -8.427  1.00 96.53  ? 279  LYS A CE  1 
ATOM   53   N  NZ  . LYS A 1 16  ? -28.321 -6.253  -7.212  1.00 99.09  ? 279  LYS A NZ  1 
ATOM   54   N  N   . ARG A 1 17  ? -22.710 -9.835  -6.578  1.00 71.67  ? 280  ARG A N   1 
ATOM   55   C  CA  . ARG A 1 17  ? -22.763 -11.265 -6.183  1.00 76.14  ? 280  ARG A CA  1 
ATOM   56   C  C   . ARG A 1 17  ? -22.246 -11.398 -4.752  1.00 69.39  ? 280  ARG A C   1 
ATOM   57   O  O   . ARG A 1 17  ? -22.844 -12.173 -3.997  1.00 68.97  ? 280  ARG A O   1 
ATOM   58   C  CB  . ARG A 1 17  ? -21.948 -12.136 -7.147  1.00 76.99  ? 280  ARG A CB  1 
ATOM   59   C  CG  . ARG A 1 17  ? -22.793 -12.928 -8.134  1.00 71.67  ? 280  ARG A CG  1 
ATOM   60   C  CD  . ARG A 1 17  ? -21.934 -13.617 -9.164  1.00 61.22  ? 280  ARG A CD  1 
ATOM   61   N  NE  . ARG A 1 17  ? -21.320 -12.640 -10.041 1.00 56.22  ? 280  ARG A NE  1 
ATOM   62   C  CZ  . ARG A 1 17  ? -20.487 -12.930 -11.035 1.00 58.17  ? 280  ARG A CZ  1 
ATOM   63   N  NH1 . ARG A 1 17  ? -20.130 -14.182 -11.269 1.00 57.57  ? 280  ARG A NH1 1 
ATOM   64   N  NH2 . ARG A 1 17  ? -19.999 -11.960 -11.789 1.00 59.24  ? 280  ARG A NH2 1 
ATOM   65   N  N   . ILE A 1 18  ? -21.178 -10.665 -4.418  1.00 73.94  ? 281  ILE A N   1 
ATOM   66   C  CA  . ILE A 1 18  ? -20.478 -10.727 -3.100  1.00 79.52  ? 281  ILE A CA  1 
ATOM   67   C  C   . ILE A 1 18  ? -21.317 -9.956  -2.077  1.00 84.47  ? 281  ILE A C   1 
ATOM   68   O  O   . ILE A 1 18  ? -21.607 -10.550 -1.001  1.00 82.35  ? 281  ILE A O   1 
ATOM   69   C  CB  . ILE A 1 18  ? -19.024 -10.214 -3.217  1.00 77.75  ? 281  ILE A CB  1 
ATOM   70   C  CG1 . ILE A 1 18  ? -18.197 -11.147 -4.106  1.00 77.26  ? 281  ILE A CG1 1 
ATOM   71   C  CG2 . ILE A 1 18  ? -18.377 -10.050 -1.848  1.00 76.01  ? 281  ILE A CG2 1 
ATOM   72   C  CD1 . ILE A 1 18  ? -16.893 -10.565 -4.581  1.00 77.59  ? 281  ILE A CD1 1 
ATOM   73   N  N   . GLU A 1 19  ? -21.720 -8.721  -2.428  1.00 89.98  ? 282  GLU A N   1 
ATOM   74   C  CA  . GLU A 1 19  ? -22.635 -7.843  -1.638  1.00 91.00  ? 282  GLU A CA  1 
ATOM   75   C  C   . GLU A 1 19  ? -23.809 -8.669  -1.118  1.00 86.21  ? 282  GLU A C   1 
ATOM   76   O  O   . GLU A 1 19  ? -24.134 -8.526  0.071   1.00 82.24  ? 282  GLU A O   1 
ATOM   77   C  CB  . GLU A 1 19  ? -23.238 -6.718  -2.480  1.00 96.98  ? 282  GLU A CB  1 
ATOM   78   C  CG  . GLU A 1 19  ? -22.331 -5.522  -2.694  1.00 106.79 ? 282  GLU A CG  1 
ATOM   79   C  CD  . GLU A 1 19  ? -22.853 -4.532  -3.731  1.00 117.92 ? 282  GLU A CD  1 
ATOM   80   O  OE1 . GLU A 1 19  ? -24.096 -4.428  -3.887  1.00 114.08 ? 282  GLU A OE1 1 
ATOM   81   O  OE2 . GLU A 1 19  ? -22.020 -3.876  -4.398  1.00 115.48 ? 282  GLU A OE2 1 
ATOM   82   N  N   . LYS A 1 20  ? -24.408 -9.479  -1.999  1.00 84.70  ? 283  LYS A N   1 
ATOM   83   C  CA  . LYS A 1 20  ? -25.618 -10.297 -1.722  1.00 88.59  ? 283  LYS A CA  1 
ATOM   84   C  C   . LYS A 1 20  ? -25.316 -11.377 -0.680  1.00 92.77  ? 283  LYS A C   1 
ATOM   85   O  O   . LYS A 1 20  ? -26.132 -11.499 0.253   1.00 97.65  ? 283  LYS A O   1 
ATOM   86   C  CB  . LYS A 1 20  ? -26.157 -10.967 -2.989  1.00 91.48  ? 283  LYS A CB  1 
ATOM   87   C  CG  . LYS A 1 20  ? -27.286 -11.963 -2.740  1.00 87.87  ? 283  LYS A CG  1 
ATOM   88   C  CD  . LYS A 1 20  ? -28.281 -12.051 -3.878  1.00 91.03  ? 283  LYS A CD  1 
ATOM   89   C  CE  . LYS A 1 20  ? -29.585 -12.726 -3.506  1.00 90.92  ? 283  LYS A CE  1 
ATOM   90   N  NZ  . LYS A 1 20  ? -29.442 -14.199 -3.430  1.00 87.04  ? 283  LYS A NZ  1 
ATOM   91   N  N   . ILE A 1 21  ? -24.234 -12.151 -0.850  1.00 87.12  ? 284  ILE A N   1 
ATOM   92   C  CA  . ILE A 1 21  ? -23.876 -13.283 0.062   1.00 88.40  ? 284  ILE A CA  1 
ATOM   93   C  C   . ILE A 1 21  ? -23.554 -12.702 1.444   1.00 87.37  ? 284  ILE A C   1 
ATOM   94   O  O   . ILE A 1 21  ? -24.027 -13.279 2.461   1.00 76.38  ? 284  ILE A O   1 
ATOM   95   C  CB  . ILE A 1 21  ? -22.712 -14.128 -0.505  1.00 92.48  ? 284  ILE A CB  1 
ATOM   96   C  CG1 . ILE A 1 21  ? -23.122 -14.856 -1.787  1.00 89.17  ? 284  ILE A CG1 1 
ATOM   97   C  CG2 . ILE A 1 21  ? -22.174 -15.108 0.533   1.00 83.85  ? 284  ILE A CG2 1 
ATOM   98   C  CD1 . ILE A 1 21  ? -21.960 -15.237 -2.677  1.00 89.05  ? 284  ILE A CD1 1 
ATOM   99   N  N   . LYS A 1 22  ? -22.808 -11.591 1.466   1.00 90.37  ? 285  LYS A N   1 
ATOM   100  C  CA  . LYS A 1 22  ? -22.387 -10.869 2.699   1.00 97.94  ? 285  LYS A CA  1 
ATOM   101  C  C   . LYS A 1 22  ? -23.607 -10.590 3.586   1.00 88.49  ? 285  LYS A C   1 
ATOM   102  O  O   . LYS A 1 22  ? -23.504 -10.828 4.796   1.00 78.23  ? 285  LYS A O   1 
ATOM   103  C  CB  . LYS A 1 22  ? -21.648 -9.579  2.329   1.00 111.33 ? 285  LYS A CB  1 
ATOM   104  C  CG  . LYS A 1 22  ? -21.216 -8.711  3.505   1.00 124.68 ? 285  LYS A CG  1 
ATOM   105  C  CD  . LYS A 1 22  ? -20.337 -7.533  3.119   1.00 131.89 ? 285  LYS A CD  1 
ATOM   106  C  CE  . LYS A 1 22  ? -20.096 -6.581  4.274   1.00 137.28 ? 285  LYS A CE  1 
ATOM   107  N  NZ  . LYS A 1 22  ? -19.497 -5.303  3.822   1.00 140.02 ? 285  LYS A NZ  1 
ATOM   108  N  N   . GLN A 1 23  ? -24.705 -10.124 2.988   1.00 95.09  ? 286  GLN A N   1 
ATOM   109  C  CA  . GLN A 1 23  ? -25.924 -9.764  3.764   1.00 96.85  ? 286  GLN A CA  1 
ATOM   110  C  C   . GLN A 1 23  ? -26.594 -11.023 4.321   1.00 94.77  ? 286  GLN A C   1 
ATOM   111  O  O   . GLN A 1 23  ? -26.978 -11.000 5.498   1.00 105.92 ? 286  GLN A O   1 
ATOM   112  C  CB  . GLN A 1 23  ? -26.893 -8.970  2.889   1.00 92.17  ? 286  GLN A CB  1 
ATOM   113  C  CG  . GLN A 1 23  ? -26.277 -7.715  2.293   1.00 97.18  ? 286  GLN A CG  1 
ATOM   114  C  CD  . GLN A 1 23  ? -27.250 -6.994  1.396   1.00 103.25 ? 286  GLN A CD  1 
ATOM   115  O  OE1 . GLN A 1 23  ? -28.424 -7.347  1.314   1.00 101.11 ? 286  GLN A OE1 1 
ATOM   116  N  NE2 . GLN A 1 23  ? -26.767 -5.969  0.714   1.00 111.20 ? 286  GLN A NE2 1 
ATOM   117  N  N   . GLU A 1 24  ? -26.736 -12.070 3.509   1.00 90.00  ? 287  GLU A N   1 
ATOM   118  C  CA  . GLU A 1 24  ? -27.451 -13.281 3.975   1.00 94.01  ? 287  GLU A CA  1 
ATOM   119  C  C   . GLU A 1 24  ? -26.702 -13.855 5.175   1.00 101.02 ? 287  GLU A C   1 
ATOM   120  O  O   . GLU A 1 24  ? -27.305 -14.644 5.919   1.00 103.20 ? 287  GLU A O   1 
ATOM   121  C  CB  . GLU A 1 24  ? -27.559 -14.312 2.852   1.00 101.02 ? 287  GLU A CB  1 
ATOM   122  C  CG  . GLU A 1 24  ? -28.607 -13.966 1.813   1.00 110.64 ? 287  GLU A CG  1 
ATOM   123  C  CD  . GLU A 1 24  ? -28.064 -13.421 0.504   1.00 116.96 ? 287  GLU A CD  1 
ATOM   124  O  OE1 . GLU A 1 24  ? -28.674 -12.483 -0.039  1.00 117.60 ? 287  GLU A OE1 1 
ATOM   125  O  OE2 . GLU A 1 24  ? -27.039 -13.945 0.025   1.00 111.03 ? 287  GLU A OE2 1 
ATOM   126  N  N   . HIS A 1 25  ? -25.429 -13.487 5.332   0.50 104.09 ? 288  HIS A N   1 
ATOM   127  C  CA  . HIS A 1 25  ? -24.610 -13.981 6.470   0.50 104.37 ? 288  HIS A CA  1 
ATOM   128  C  C   . HIS A 1 25  ? -24.003 -12.778 7.201   0.50 107.04 ? 288  HIS A C   1 
ATOM   129  O  O   . HIS A 1 25  ? -22.834 -12.869 7.620   0.50 106.91 ? 288  HIS A O   1 
ATOM   130  C  CB  . HIS A 1 25  ? -23.566 -14.984 5.963   0.50 101.71 ? 288  HIS A CB  1 
ATOM   131  C  CG  . HIS A 1 25  ? -24.147 -16.061 5.112   0.50 98.19  ? 288  HIS A CG  1 
ATOM   132  N  ND1 . HIS A 1 25  ? -24.815 -17.143 5.646   0.50 101.24 ? 288  HIS A ND1 1 
ATOM   133  C  CD2 . HIS A 1 25  ? -24.170 -16.225 3.772   0.50 96.23  ? 288  HIS A CD2 1 
ATOM   134  C  CE1 . HIS A 1 25  ? -25.224 -17.930 4.672   0.50 98.68  ? 288  HIS A CE1 1 
ATOM   135  N  NE2 . HIS A 1 25  ? -24.840 -17.388 3.512   0.50 94.77  ? 288  HIS A NE2 1 
ATOM   136  N  N   . GLU A 1 26  ? -24.777 -11.701 7.355   0.50 110.95 ? 289  GLU A N   1 
ATOM   137  C  CA  . GLU A 1 26  ? -24.279 -10.463 8.014   0.50 111.85 ? 289  GLU A CA  1 
ATOM   138  C  C   . GLU A 1 26  ? -23.877 -10.765 9.461   0.50 115.60 ? 289  GLU A C   1 
ATOM   139  O  O   . GLU A 1 26  ? -23.024 -10.037 10.003  0.50 113.32 ? 289  GLU A O   1 
ATOM   140  C  CB  . GLU A 1 26  ? -25.363 -9.384  7.977   0.50 109.26 ? 289  GLU A CB  1 
ATOM   141  C  CG  . GLU A 1 26  ? -24.878 -8.023  8.438   0.50 106.85 ? 289  GLU A CG  1 
ATOM   142  C  CD  . GLU A 1 26  ? -24.108 -7.242  7.389   0.50 105.11 ? 289  GLU A CD  1 
ATOM   143  O  OE1 . GLU A 1 26  ? -23.224 -6.454  7.773   0.50 100.81 ? 289  GLU A OE1 1 
ATOM   144  O  OE2 . GLU A 1 26  ? -24.405 -7.415  6.189   0.50 100.75 ? 289  GLU A OE2 1 
ATOM   145  N  N   . THR A 1 27  ? -24.473 -11.798 10.062  0.50 118.78 ? 290  THR A N   1 
ATOM   146  C  CA  . THR A 1 27  ? -24.167 -12.145 11.474  0.50 121.10 ? 290  THR A CA  1 
ATOM   147  C  C   . THR A 1 27  ? -23.075 -13.218 11.514  0.50 119.98 ? 290  THR A C   1 
ATOM   148  O  O   . THR A 1 27  ? -23.117 -14.060 12.431  0.50 122.05 ? 290  THR A O   1 
ATOM   149  C  CB  . THR A 1 27  ? -25.426 -12.608 12.215  0.50 124.17 ? 290  THR A CB  1 
ATOM   150  O  OG1 . THR A 1 27  ? -25.909 -13.786 11.569  0.50 128.91 ? 290  THR A OG1 1 
ATOM   151  C  CG2 . THR A 1 27  ? -26.510 -11.554 12.242  0.50 122.56 ? 290  THR A CG2 1 
ATOM   152  N  N   . SER A 1 28  ? -22.150 -13.193 10.550  0.50 115.61 ? 291  SER A N   1 
ATOM   153  C  CA  . SER A 1 28  ? -21.035 -14.175 10.526  0.50 108.09 ? 291  SER A CA  1 
ATOM   154  C  C   . SER A 1 28  ? -19.834 -13.598 9.777   0.50 103.35 ? 291  SER A C   1 
ATOM   155  O  O   . SER A 1 28  ? -18.723 -14.124 9.959   0.50 103.03 ? 291  SER A O   1 
ATOM   156  C  CB  . SER A 1 28  ? -21.479 -15.474 9.910   0.50 104.81 ? 291  SER A CB  1 
ATOM   157  O  OG  . SER A 1 28  ? -22.520 -16.067 10.672  0.50 102.51 ? 291  SER A OG  1 
ATOM   158  N  N   . TRP A 1 29  ? -20.046 -12.560 8.968   0.50 102.80 ? 292  TRP A N   1 
ATOM   159  C  CA  . TRP A 1 29  ? -18.937 -12.035 8.127   0.50 102.69 ? 292  TRP A CA  1 
ATOM   160  C  C   . TRP A 1 29  ? -17.669 -11.890 8.974   0.50 101.69 ? 292  TRP A C   1 
ATOM   161  O  O   . TRP A 1 29  ? -17.709 -11.148 9.970   0.50 101.51 ? 292  TRP A O   1 
ATOM   162  C  CB  . TRP A 1 29  ? -19.339 -10.718 7.453   0.50 99.22  ? 292  TRP A CB  1 
ATOM   163  C  CG  . TRP A 1 29  ? -18.754 -10.539 6.086   0.50 98.11  ? 292  TRP A CG  1 
ATOM   164  C  CD1 . TRP A 1 29  ? -17.933 -9.534  5.666   0.50 97.78  ? 292  TRP A CD1 1 
ATOM   165  C  CD2 . TRP A 1 29  ? -18.942 -11.402 4.950   0.50 96.19  ? 292  TRP A CD2 1 
ATOM   166  N  NE1 . TRP A 1 29  ? -17.602 -9.707  4.349   0.50 96.59  ? 292  TRP A NE1 1 
ATOM   167  C  CE2 . TRP A 1 29  ? -18.205 -10.845 3.883   0.50 96.26  ? 292  TRP A CE2 1 
ATOM   168  C  CE3 . TRP A 1 29  ? -19.658 -12.583 4.729   0.50 93.41  ? 292  TRP A CE3 1 
ATOM   169  C  CZ2 . TRP A 1 29  ? -18.166 -11.432 2.620   0.50 94.20  ? 292  TRP A CZ2 1 
ATOM   170  C  CZ3 . TRP A 1 29  ? -19.619 -13.161 3.480   0.50 92.48  ? 292  TRP A CZ3 1 
ATOM   171  C  CH2 . TRP A 1 29  ? -18.883 -12.592 2.442   0.50 92.69  ? 292  TRP A CH2 1 
ATOM   172  N  N   . HIS A 1 30  ? -16.598 -12.588 8.590   0.50 101.95 ? 293  HIS A N   1 
ATOM   173  C  CA  . HIS A 1 30  ? -15.310 -12.504 9.329   0.50 102.12 ? 293  HIS A CA  1 
ATOM   174  C  C   . HIS A 1 30  ? -14.151 -12.578 8.334   0.50 104.95 ? 293  HIS A C   1 
ATOM   175  O  O   . HIS A 1 30  ? -13.961 -13.648 7.732   0.50 108.24 ? 293  HIS A O   1 
ATOM   176  C  CB  . HIS A 1 30  ? -15.232 -13.587 10.413  0.50 100.77 ? 293  HIS A CB  1 
ATOM   177  C  CG  . HIS A 1 30  ? -15.213 -14.992 9.917   0.50 98.28  ? 293  HIS A CG  1 
ATOM   178  N  ND1 . HIS A 1 30  ? -16.364 -15.669 9.574   0.50 98.60  ? 293  HIS A ND1 1 
ATOM   179  C  CD2 . HIS A 1 30  ? -14.195 -15.861 9.744   0.50 99.03  ? 293  HIS A CD2 1 
ATOM   180  C  CE1 . HIS A 1 30  ? -16.056 -16.891 9.194   0.50 97.52  ? 293  HIS A CE1 1 
ATOM   181  N  NE2 . HIS A 1 30  ? -14.730 -17.034 9.289   0.50 97.91  ? 293  HIS A NE2 1 
ATOM   182  N  N   . TYR A 1 31  ? -13.424 -11.473 8.161   0.50 106.53 ? 294  TYR A N   1 
ATOM   183  C  CA  . TYR A 1 31  ? -12.303 -11.442 7.187   0.50 109.82 ? 294  TYR A CA  1 
ATOM   184  C  C   . TYR A 1 31  ? -11.103 -12.199 7.761   0.50 111.23 ? 294  TYR A C   1 
ATOM   185  O  O   . TYR A 1 31  ? -10.080 -11.557 8.059   0.50 107.86 ? 294  TYR A O   1 
ATOM   186  C  CB  . TYR A 1 31  ? -11.935 -9.994  6.863   0.50 112.37 ? 294  TYR A CB  1 
ATOM   187  C  CG  . TYR A 1 31  ? -10.957 -9.808  5.730   0.50 118.68 ? 294  TYR A CG  1 
ATOM   188  C  CD1 . TYR A 1 31  ? -9.626  -9.519  5.976   0.50 121.40 ? 294  TYR A CD1 1 
ATOM   189  C  CD2 . TYR A 1 31  ? -11.365 -9.904  4.411   0.50 121.54 ? 294  TYR A CD2 1 
ATOM   190  C  CE1 . TYR A 1 31  ? -8.723  -9.338  4.942   0.50 121.09 ? 294  TYR A CE1 1 
ATOM   191  C  CE2 . TYR A 1 31  ? -10.476 -9.727  3.364   0.50 120.61 ? 294  TYR A CE2 1 
ATOM   192  C  CZ  . TYR A 1 31  ? -9.150  -9.442  3.631   0.50 121.17 ? 294  TYR A CZ  1 
ATOM   193  O  OH  . TYR A 1 31  ? -8.265  -9.265  2.608   0.50 124.01 ? 294  TYR A OH  1 
ATOM   194  N  N   . ASP A 1 32  ? -11.220 -13.524 7.890   0.50 115.16 ? 295  ASP A N   1 
ATOM   195  C  CA  . ASP A 1 32  ? -10.127 -14.335 8.491   0.50 119.12 ? 295  ASP A CA  1 
ATOM   196  C  C   . ASP A 1 32  ? -8.791  -13.849 7.925   0.50 122.64 ? 295  ASP A C   1 
ATOM   197  O  O   . ASP A 1 32  ? -8.693  -13.698 6.692   0.50 125.13 ? 295  ASP A O   1 
ATOM   198  C  CB  . ASP A 1 32  ? -10.351 -15.834 8.265   0.50 117.11 ? 295  ASP A CB  1 
ATOM   199  C  CG  . ASP A 1 32  ? -9.260  -16.715 8.846   0.50 116.31 ? 295  ASP A CG  1 
ATOM   200  O  OD1 . ASP A 1 32  ? -8.287  -16.164 9.397   0.50 114.54 ? 295  ASP A OD1 1 
ATOM   201  O  OD2 . ASP A 1 32  ? -9.394  -17.950 8.745   0.50 116.71 ? 295  ASP A OD2 1 
ATOM   202  N  N   . GLN A 1 33  ? -7.809  -13.601 8.795   0.50 123.82 ? 296  GLN A N   1 
ATOM   203  C  CA  . GLN A 1 33  ? -6.511  -13.046 8.326   0.50 124.34 ? 296  GLN A CA  1 
ATOM   204  C  C   . GLN A 1 33  ? -5.531  -14.193 8.071   0.50 120.31 ? 296  GLN A C   1 
ATOM   205  O  O   . GLN A 1 33  ? -4.428  -13.922 7.564   0.50 117.40 ? 296  GLN A O   1 
ATOM   206  C  CB  . GLN A 1 33  ? -5.956  -12.042 9.340   0.50 125.44 ? 296  GLN A CB  1 
ATOM   207  C  CG  . GLN A 1 33  ? -6.833  -10.811 9.524   0.50 125.74 ? 296  GLN A CG  1 
ATOM   208  C  CD  . GLN A 1 33  ? -6.889  -9.943  8.291   0.50 126.57 ? 296  GLN A CD  1 
ATOM   209  O  OE1 . GLN A 1 33  ? -6.475  -10.341 7.205   0.50 126.74 ? 296  GLN A OE1 1 
ATOM   210  N  NE2 . GLN A 1 33  ? -7.410  -8.738  8.451   0.50 125.59 ? 296  GLN A NE2 1 
ATOM   211  N  N   . ASP A 1 34  ? -5.928  -15.421 8.408   0.50 118.60 ? 297  ASP A N   1 
ATOM   212  C  CA  . ASP A 1 34  ? -5.063  -16.600 8.141   0.50 116.23 ? 297  ASP A CA  1 
ATOM   213  C  C   . ASP A 1 34  ? -5.590  -17.326 6.901   0.50 115.29 ? 297  ASP A C   1 
ATOM   214  O  O   . ASP A 1 34  ? -5.514  -18.567 6.868   0.50 117.01 ? 297  ASP A O   1 
ATOM   215  C  CB  . ASP A 1 34  ? -4.987  -17.528 9.352   0.50 115.60 ? 297  ASP A CB  1 
ATOM   216  C  CG  . ASP A 1 34  ? -4.192  -16.947 10.509  0.50 115.65 ? 297  ASP A CG  1 
ATOM   217  O  OD1 . ASP A 1 34  ? -3.793  -15.769 10.413  0.50 114.98 ? 297  ASP A OD1 1 
ATOM   218  O  OD2 . ASP A 1 34  ? -3.975  -17.679 11.493  0.50 114.20 ? 297  ASP A OD2 1 
ATOM   219  N  N   . HIS A 1 35  ? -6.113  -16.571 5.930   1.00 114.51 ? 298  HIS A N   1 
ATOM   220  C  CA  . HIS A 1 35  ? -6.675  -17.194 4.700   1.00 106.25 ? 298  HIS A CA  1 
ATOM   221  C  C   . HIS A 1 35  ? -5.539  -17.820 3.884   1.00 97.23  ? 298  HIS A C   1 
ATOM   222  O  O   . HIS A 1 35  ? -4.500  -17.163 3.720   1.00 89.67  ? 298  HIS A O   1 
ATOM   223  C  CB  . HIS A 1 35  ? -7.530  -16.184 3.918   1.00 101.24 ? 298  HIS A CB  1 
ATOM   224  C  CG  . HIS A 1 35  ? -6.774  -15.167 3.135   1.00 89.70  ? 298  HIS A CG  1 
ATOM   225  N  ND1 . HIS A 1 35  ? -6.681  -13.852 3.539   1.00 92.57  ? 298  HIS A ND1 1 
ATOM   226  C  CD2 . HIS A 1 35  ? -6.122  -15.251 1.957   1.00 83.73  ? 298  HIS A CD2 1 
ATOM   227  C  CE1 . HIS A 1 35  ? -5.984  -13.172 2.654   1.00 85.59  ? 298  HIS A CE1 1 
ATOM   228  N  NE2 . HIS A 1 35  ? -5.628  -14.008 1.675   1.00 85.12  ? 298  HIS A NE2 1 
ATOM   229  N  N   . PRO A 1 36  ? -5.696  -19.066 3.391   1.00 81.60  ? 299  PRO A N   1 
ATOM   230  C  CA  . PRO A 1 36  ? -4.634  -19.742 2.647   1.00 79.51  ? 299  PRO A CA  1 
ATOM   231  C  C   . PRO A 1 36  ? -4.522  -19.368 1.163   1.00 84.51  ? 299  PRO A C   1 
ATOM   232  O  O   . PRO A 1 36  ? -3.689  -19.936 0.500   1.00 92.42  ? 299  PRO A O   1 
ATOM   233  C  CB  . PRO A 1 36  ? -5.107  -21.193 2.716   1.00 76.19  ? 299  PRO A CB  1 
ATOM   234  C  CG  . PRO A 1 36  ? -6.609  -21.088 2.688   1.00 77.67  ? 299  PRO A CG  1 
ATOM   235  C  CD  . PRO A 1 36  ? -6.900  -19.880 3.549   1.00 77.59  ? 299  PRO A CD  1 
ATOM   236  N  N   . TYR A 1 37  ? -5.326  -18.422 0.686   1.00 87.45  ? 300  TYR A N   1 
ATOM   237  C  CA  . TYR A 1 37  ? -5.361  -18.095 -0.766  1.00 86.83  ? 300  TYR A CA  1 
ATOM   238  C  C   . TYR A 1 37  ? -4.191  -17.173 -1.098  1.00 84.78  ? 300  TYR A C   1 
ATOM   239  O  O   . TYR A 1 37  ? -4.045  -16.124 -0.443  1.00 86.64  ? 300  TYR A O   1 
ATOM   240  C  CB  . TYR A 1 37  ? -6.728  -17.532 -1.178  1.00 81.24  ? 300  TYR A CB  1 
ATOM   241  C  CG  . TYR A 1 37  ? -7.847  -18.386 -0.651  1.00 69.41  ? 300  TYR A CG  1 
ATOM   242  C  CD1 . TYR A 1 37  ? -8.168  -19.595 -1.237  1.00 67.74  ? 300  TYR A CD1 1 
ATOM   243  C  CD2 . TYR A 1 37  ? -8.482  -18.053 0.526   1.00 68.76  ? 300  TYR A CD2 1 
ATOM   244  C  CE1 . TYR A 1 37  ? -9.137  -20.423 -0.698  1.00 63.12  ? 300  TYR A CE1 1 
ATOM   245  C  CE2 . TYR A 1 37  ? -9.458  -18.863 1.074   1.00 64.56  ? 300  TYR A CE2 1 
ATOM   246  C  CZ  . TYR A 1 37  ? -9.789  -20.047 0.459   1.00 57.16  ? 300  TYR A CZ  1 
ATOM   247  O  OH  . TYR A 1 37  ? -10.746 -20.820 1.030   1.00 67.18  ? 300  TYR A OH  1 
ATOM   248  N  N   . LYS A 1 38  ? -3.371  -17.592 -2.065  1.00 85.36  ? 301  LYS A N   1 
ATOM   249  C  CA  . LYS A 1 38  ? -2.401  -16.704 -2.755  1.00 93.11  ? 301  LYS A CA  1 
ATOM   250  C  C   . LYS A 1 38  ? -3.013  -16.240 -4.080  1.00 90.45  ? 301  LYS A C   1 
ATOM   251  O  O   . LYS A 1 38  ? -3.150  -15.021 -4.247  1.00 99.22  ? 301  LYS A O   1 
ATOM   252  C  CB  . LYS A 1 38  ? -1.042  -17.384 -2.976  1.00 94.55  ? 301  LYS A CB  1 
ATOM   253  C  CG  . LYS A 1 38  ? 0.127   -16.423 -3.195  1.00 94.37  ? 301  LYS A CG  1 
ATOM   254  C  CD  . LYS A 1 38  ? 0.478   -15.566 -1.975  1.00 102.66 ? 301  LYS A CD  1 
ATOM   255  C  CE  . LYS A 1 38  ? 0.994   -14.179 -2.316  1.00 104.03 ? 301  LYS A CE  1 
ATOM   256  N  NZ  . LYS A 1 38  ? 2.460   -14.156 -2.547  1.00 99.37  ? 301  LYS A NZ  1 
ATOM   257  N  N   . THR A 1 39  ? -3.404  -17.167 -4.965  1.00 89.22  ? 302  THR A N   1 
ATOM   258  C  CA  . THR A 1 39  ? -3.729  -16.867 -6.392  1.00 85.85  ? 302  THR A CA  1 
ATOM   259  C  C   . THR A 1 39  ? -5.219  -16.540 -6.573  1.00 84.84  ? 302  THR A C   1 
ATOM   260  O  O   . THR A 1 39  ? -5.552  -15.937 -7.611  1.00 71.90  ? 302  THR A O   1 
ATOM   261  C  CB  . THR A 1 39  ? -3.316  -18.017 -7.316  1.00 80.37  ? 302  THR A CB  1 
ATOM   262  O  OG1 . THR A 1 39  ? -4.319  -19.019 -7.170  1.00 79.12  ? 302  THR A OG1 1 
ATOM   263  C  CG2 . THR A 1 39  ? -1.940  -18.567 -7.005  1.00 79.02  ? 302  THR A CG2 1 
ATOM   264  N  N   . TRP A 1 40  ? -6.065  -16.959 -5.623  1.00 80.42  ? 303  TRP A N   1 
ATOM   265  C  CA  . TRP A 1 40  ? -7.497  -16.580 -5.511  1.00 71.49  ? 303  TRP A CA  1 
ATOM   266  C  C   . TRP A 1 40  ? -7.633  -15.311 -4.665  1.00 73.15  ? 303  TRP A C   1 
ATOM   267  O  O   . TRP A 1 40  ? -7.155  -15.348 -3.516  1.00 87.85  ? 303  TRP A O   1 
ATOM   268  C  CB  . TRP A 1 40  ? -8.285  -17.716 -4.863  1.00 67.95  ? 303  TRP A CB  1 
ATOM   269  C  CG  . TRP A 1 40  ? -8.433  -18.923 -5.726  1.00 68.85  ? 303  TRP A CG  1 
ATOM   270  C  CD1 . TRP A 1 40  ? -7.527  -19.918 -5.900  1.00 71.65  ? 303  TRP A CD1 1 
ATOM   271  C  CD2 . TRP A 1 40  ? -9.568  -19.269 -6.535  1.00 76.01  ? 303  TRP A CD2 1 
ATOM   272  N  NE1 . TRP A 1 40  ? -8.013  -20.858 -6.760  1.00 74.94  ? 303  TRP A NE1 1 
ATOM   273  C  CE2 . TRP A 1 40  ? -9.266  -20.494 -7.166  1.00 77.26  ? 303  TRP A CE2 1 
ATOM   274  C  CE3 . TRP A 1 40  ? -10.806 -18.667 -6.785  1.00 73.92  ? 303  TRP A CE3 1 
ATOM   275  C  CZ2 . TRP A 1 40  ? -10.163 -21.138 -8.018  1.00 71.61  ? 303  TRP A CZ2 1 
ATOM   276  C  CZ3 . TRP A 1 40  ? -11.688 -19.298 -7.630  1.00 74.69  ? 303  TRP A CZ3 1 
ATOM   277  C  CH2 . TRP A 1 40  ? -11.372 -20.517 -8.228  1.00 75.24  ? 303  TRP A CH2 1 
ATOM   278  N  N   . ALA A 1 41  ? -8.437  -14.348 -5.115  1.00 69.56  ? 304  ALA A N   1 
ATOM   279  C  CA  . ALA A 1 41  ? -8.747  -13.169 -4.276  1.00 69.50  ? 304  ALA A CA  1 
ATOM   280  C  C   . ALA A 1 41  ? -9.771  -13.590 -3.220  1.00 73.88  ? 304  ALA A C   1 
ATOM   281  O  O   . ALA A 1 41  ? -10.879 -13.977 -3.610  1.00 76.16  ? 304  ALA A O   1 
ATOM   282  C  CB  . ALA A 1 41  ? -9.281  -12.051 -5.124  1.00 58.68  ? 304  ALA A CB  1 
ATOM   283  N  N   . TYR A 1 42  ? -9.396  -13.545 -1.939  1.00 84.70  ? 305  TYR A N   1 
ATOM   284  C  CA  . TYR A 1 42  ? -10.316 -13.902 -0.829  1.00 85.71  ? 305  TYR A CA  1 
ATOM   285  C  C   . TYR A 1 42  ? -11.145 -12.671 -0.486  1.00 90.68  ? 305  TYR A C   1 
ATOM   286  O  O   . TYR A 1 42  ? -10.567 -11.573 -0.422  1.00 103.77 ? 305  TYR A O   1 
ATOM   287  C  CB  . TYR A 1 42  ? -9.520  -14.382 0.384   1.00 80.67  ? 305  TYR A CB  1 
ATOM   288  C  CG  . TYR A 1 42  ? -10.261 -14.405 1.695   1.00 77.06  ? 305  TYR A CG  1 
ATOM   289  C  CD1 . TYR A 1 42  ? -11.017 -15.501 2.065   1.00 71.92  ? 305  TYR A CD1 1 
ATOM   290  C  CD2 . TYR A 1 42  ? -10.175 -13.345 2.581   1.00 74.36  ? 305  TYR A CD2 1 
ATOM   291  C  CE1 . TYR A 1 42  ? -11.686 -15.538 3.276   1.00 76.49  ? 305  TYR A CE1 1 
ATOM   292  C  CE2 . TYR A 1 42  ? -10.840 -13.364 3.795   1.00 74.60  ? 305  TYR A CE2 1 
ATOM   293  C  CZ  . TYR A 1 42  ? -11.597 -14.466 4.144   1.00 75.13  ? 305  TYR A CZ  1 
ATOM   294  O  OH  . TYR A 1 42  ? -12.257 -14.499 5.335   1.00 69.72  ? 305  TYR A OH  1 
ATOM   295  N  N   . HIS A 1 43  ? -12.450 -12.842 -0.287  1.00 85.23  ? 306  HIS A N   1 
ATOM   296  C  CA  . HIS A 1 43  ? -13.314 -11.656 -0.060  1.00 78.98  ? 306  HIS A CA  1 
ATOM   297  C  C   . HIS A 1 43  ? -13.955 -11.714 1.333   1.00 77.08  ? 306  HIS A C   1 
ATOM   298  O  O   . HIS A 1 43  ? -14.419 -10.661 1.791   1.00 94.79  ? 306  HIS A O   1 
ATOM   299  C  CB  . HIS A 1 43  ? -14.350 -11.542 -1.187  1.00 73.81  ? 306  HIS A CB  1 
ATOM   300  C  CG  . HIS A 1 43  ? -13.797 -11.179 -2.521  1.00 66.34  ? 306  HIS A CG  1 
ATOM   301  N  ND1 . HIS A 1 43  ? -13.780 -9.880  -2.981  1.00 63.89  ? 306  HIS A ND1 1 
ATOM   302  C  CD2 . HIS A 1 43  ? -13.279 -11.937 -3.509  1.00 65.98  ? 306  HIS A CD2 1 
ATOM   303  C  CE1 . HIS A 1 43  ? -13.256 -9.850  -4.187  1.00 63.60  ? 306  HIS A CE1 1 
ATOM   304  N  NE2 . HIS A 1 43  ? -12.940 -11.098 -4.532  1.00 64.78  ? 306  HIS A NE2 1 
ATOM   305  N  N   . GLY A 1 44  ? -13.987 -12.883 1.975   1.00 64.24  ? 307  GLY A N   1 
ATOM   306  C  CA  . GLY A 1 44  ? -14.530 -12.966 3.345   1.00 68.81  ? 307  GLY A CA  1 
ATOM   307  C  C   . GLY A 1 44  ? -14.973 -14.364 3.725   1.00 74.54  ? 307  GLY A C   1 
ATOM   308  O  O   . GLY A 1 44  ? -14.806 -15.273 2.904   1.00 87.08  ? 307  GLY A O   1 
ATOM   309  N  N   . SER A 1 45  ? -15.524 -14.535 4.929   1.00 78.92  ? 308  SER A N   1 
ATOM   310  C  CA  . SER A 1 45  ? -15.936 -15.880 5.409   1.00 82.62  ? 308  SER A CA  1 
ATOM   311  C  C   . SER A 1 45  ? -17.233 -15.758 6.200   1.00 85.69  ? 308  SER A C   1 
ATOM   312  O  O   . SER A 1 45  ? -17.586 -14.622 6.510   1.00 93.54  ? 308  SER A O   1 
ATOM   313  C  CB  . SER A 1 45  ? -14.848 -16.526 6.228   1.00 86.60  ? 308  SER A CB  1 
ATOM   314  O  OG  . SER A 1 45  ? -13.632 -16.587 5.496   1.00 86.94  ? 308  SER A OG  1 
ATOM   315  N  N   . TYR A 1 46  ? -17.898 -16.886 6.487   1.00 91.63  ? 309  TYR A N   1 
ATOM   316  C  CA  . TYR A 1 46  ? -19.185 -16.982 7.235   1.00 92.10  ? 309  TYR A CA  1 
ATOM   317  C  C   . TYR A 1 46  ? -19.386 -18.433 7.727   1.00 98.78  ? 309  TYR A C   1 
ATOM   318  O  O   . TYR A 1 46  ? -18.774 -19.352 7.148   1.00 108.41 ? 309  TYR A O   1 
ATOM   319  C  CB  . TYR A 1 46  ? -20.337 -16.432 6.378   1.00 88.89  ? 309  TYR A CB  1 
ATOM   320  C  CG  . TYR A 1 46  ? -20.854 -17.342 5.286   1.00 89.95  ? 309  TYR A CG  1 
ATOM   321  C  CD1 . TYR A 1 46  ? -21.693 -18.401 5.592   1.00 88.44  ? 309  TYR A CD1 1 
ATOM   322  C  CD2 . TYR A 1 46  ? -20.536 -17.147 3.946   1.00 88.69  ? 309  TYR A CD2 1 
ATOM   323  C  CE1 . TYR A 1 46  ? -22.180 -19.254 4.614   1.00 91.87  ? 309  TYR A CE1 1 
ATOM   324  C  CE2 . TYR A 1 46  ? -21.018 -17.993 2.952   1.00 89.85  ? 309  TYR A CE2 1 
ATOM   325  C  CZ  . TYR A 1 46  ? -21.843 -19.058 3.288   1.00 93.62  ? 309  TYR A CZ  1 
ATOM   326  O  OH  . TYR A 1 46  ? -22.364 -19.926 2.365   1.00 79.54  ? 309  TYR A OH  1 
ATOM   327  N  N   . GLU A 1 47  ? -20.230 -18.642 8.746   1.00 94.29  ? 310  GLU A N   1 
ATOM   328  C  CA  . GLU A 1 47  ? -20.375 -19.919 9.503   1.00 104.91 ? 310  GLU A CA  1 
ATOM   329  C  C   . GLU A 1 47  ? -21.172 -20.936 8.672   1.00 116.26 ? 310  GLU A C   1 
ATOM   330  O  O   . GLU A 1 47  ? -22.235 -20.573 8.134   1.00 127.50 ? 310  GLU A O   1 
ATOM   331  C  CB  . GLU A 1 47  ? -21.054 -19.632 10.849  1.00 113.53 ? 310  GLU A CB  1 
ATOM   332  C  CG  . GLU A 1 47  ? -21.504 -20.868 11.621  1.00 115.93 ? 310  GLU A CG  1 
ATOM   333  C  CD  . GLU A 1 47  ? -21.929 -20.595 13.058  1.00 118.41 ? 310  GLU A CD  1 
ATOM   334  O  OE1 . GLU A 1 47  ? -23.104 -20.874 13.402  1.00 109.31 ? 310  GLU A OE1 1 
ATOM   335  O  OE2 . GLU A 1 47  ? -21.079 -20.108 13.837  1.00 118.81 ? 310  GLU A OE2 1 
ATOM   336  N  N   . THR A 1 48  ? -20.684 -22.180 8.589   0.40 120.09 ? 311  THR A N   1 
ATOM   337  C  CA  . THR A 1 48  ? -21.313 -23.287 7.816   0.40 122.64 ? 311  THR A CA  1 
ATOM   338  C  C   . THR A 1 48  ? -21.141 -24.615 8.561   0.40 124.20 ? 311  THR A C   1 
ATOM   339  O  O   . THR A 1 48  ? -20.633 -24.594 9.699   0.40 124.39 ? 311  THR A O   1 
ATOM   340  C  CB  . THR A 1 48  ? -20.734 -23.367 6.398   0.40 125.63 ? 311  THR A CB  1 
ATOM   341  O  OG1 . THR A 1 48  ? -19.310 -23.305 6.484   0.40 129.04 ? 311  THR A OG1 1 
ATOM   342  C  CG2 . THR A 1 48  ? -21.235 -22.257 5.502   0.40 126.82 ? 311  THR A CG2 1 
ATOM   343  N  N   . LYS A 1 49  ? -21.560 -25.719 7.931   0.40 127.90 ? 312  LYS A N   1 
ATOM   344  C  CA  . LYS A 1 49  ? -21.487 -27.099 8.487   0.40 130.50 ? 312  LYS A CA  1 
ATOM   345  C  C   . LYS A 1 49  ? -21.874 -28.106 7.396   0.40 129.81 ? 312  LYS A C   1 
ATOM   346  O  O   . LYS A 1 49  ? -21.384 -29.252 7.478   0.40 127.36 ? 312  LYS A O   1 
ATOM   347  C  CB  . LYS A 1 49  ? -22.404 -27.227 9.708   0.40 131.44 ? 312  LYS A CB  1 
ATOM   348  C  CG  . LYS A 1 49  ? -22.329 -28.561 10.440  0.40 131.21 ? 312  LYS A CG  1 
ATOM   349  C  CD  . LYS A 1 49  ? -22.914 -28.515 11.836  0.40 130.75 ? 312  LYS A CD  1 
ATOM   350  C  CE  . LYS A 1 49  ? -22.240 -27.488 12.722  0.40 129.98 ? 312  LYS A CE  1 
ATOM   351  N  NZ  . LYS A 1 49  ? -22.890 -27.398 14.050  0.40 128.96 ? 312  LYS A NZ  1 
ATOM   352  N  N   . SER A 1 56  ? -18.280 -43.573 -1.184  1.00 91.94  ? 319  SER A N   1 
ATOM   353  C  CA  . SER A 1 56  ? -18.637 -44.584 -2.219  1.00 91.33  ? 319  SER A CA  1 
ATOM   354  C  C   . SER A 1 56  ? -18.997 -45.929 -1.567  1.00 84.04  ? 319  SER A C   1 
ATOM   355  O  O   . SER A 1 56  ? -18.116 -46.508 -0.896  1.00 73.85  ? 319  SER A O   1 
ATOM   356  C  CB  . SER A 1 56  ? -17.486 -44.753 -3.184  1.00 94.39  ? 319  SER A CB  1 
ATOM   357  O  OG  . SER A 1 56  ? -16.390 -45.432 -2.566  1.00 85.20  ? 319  SER A OG  1 
ATOM   358  N  N   . MET A 1 57  ? -20.209 -46.442 -1.827  1.00 70.92  ? 320  MET A N   1 
ATOM   359  C  CA  . MET A 1 57  ? -20.759 -47.704 -1.242  1.00 58.59  ? 320  MET A CA  1 
ATOM   360  C  C   . MET A 1 57  ? -20.447 -48.900 -2.158  1.00 45.34  ? 320  MET A C   1 
ATOM   361  O  O   . MET A 1 57  ? -20.299 -48.692 -3.381  1.00 43.48  ? 320  MET A O   1 
ATOM   362  C  CB  . MET A 1 57  ? -22.278 -47.583 -1.078  1.00 65.75  ? 320  MET A CB  1 
ATOM   363  C  CG  . MET A 1 57  ? -22.732 -46.204 -0.582  1.00 73.29  ? 320  MET A CG  1 
ATOM   364  S  SD  . MET A 1 57  ? -21.839 -45.667 0.911   1.00 73.69  ? 320  MET A SD  1 
ATOM   365  C  CE  . MET A 1 57  ? -22.885 -46.407 2.169   1.00 63.57  ? 320  MET A CE  1 
ATOM   366  N  N   . VAL A 1 58  ? -20.396 -50.118 -1.620  1.00 35.92  ? 321  VAL A N   1 
ATOM   367  C  CA  . VAL A 1 58  ? -20.181 -51.336 -2.446  1.00 34.73  ? 321  VAL A CA  1 
ATOM   368  C  C   . VAL A 1 58  ? -21.532 -51.883 -2.915  1.00 33.48  ? 321  VAL A C   1 
ATOM   369  O  O   . VAL A 1 58  ? -22.420 -51.993 -2.091  1.00 35.86  ? 321  VAL A O   1 
ATOM   370  C  CB  . VAL A 1 58  ? -19.362 -52.406 -1.726  1.00 34.84  ? 321  VAL A CB  1 
ATOM   371  C  CG1 . VAL A 1 58  ? -19.237 -53.674 -2.565  1.00 33.81  ? 321  VAL A CG1 1 
ATOM   372  C  CG2 . VAL A 1 58  ? -17.997 -51.874 -1.379  1.00 39.91  ? 321  VAL A CG2 1 
ATOM   373  N  N   . ASN A 1 59  ? -21.638 -52.175 -4.211  1.00 29.36  ? 322  ASN A N   1 
ATOM   374  C  CA  . ASN A 1 59  ? -22.784 -52.857 -4.861  1.00 30.64  ? 322  ASN A CA  1 
ATOM   375  C  C   . ASN A 1 59  ? -22.696 -54.343 -4.535  1.00 29.69  ? 322  ASN A C   1 
ATOM   376  O  O   . ASN A 1 59  ? -21.832 -55.040 -5.119  1.00 33.24  ? 322  ASN A O   1 
ATOM   377  C  CB  . ASN A 1 59  ? -22.778 -52.626 -6.378  1.00 30.63  ? 322  ASN A CB  1 
ATOM   378  C  CG  . ASN A 1 59  ? -23.945 -53.296 -7.078  1.00 33.26  ? 322  ASN A CG  1 
ATOM   379  O  OD1 . ASN A 1 59  ? -24.309 -54.430 -6.757  1.00 31.04  ? 322  ASN A OD1 1 
ATOM   380  N  ND2 . ASN A 1 59  ? -24.581 -52.574 -7.996  1.00 36.15  ? 322  ASN A ND2 1 
ATOM   381  N  N   . GLY A 1 60  ? -23.570 -54.837 -3.668  1.00 32.55  ? 323  GLY A N   1 
ATOM   382  C  CA  . GLY A 1 60  ? -23.504 -56.226 -3.175  1.00 28.96  ? 323  GLY A CA  1 
ATOM   383  C  C   . GLY A 1 60  ? -23.841 -57.261 -4.254  1.00 32.76  ? 323  GLY A C   1 
ATOM   384  O  O   . GLY A 1 60  ? -23.344 -58.409 -4.204  1.00 33.62  ? 323  GLY A O   1 
ATOM   385  N  N   . VAL A 1 61  ? -24.680 -56.914 -5.218  1.00 29.84  ? 324  VAL A N   1 
ATOM   386  C  CA  . VAL A 1 61  ? -25.043 -57.900 -6.275  1.00 29.31  ? 324  VAL A CA  1 
ATOM   387  C  C   . VAL A 1 61  ? -23.766 -58.173 -7.080  1.00 27.64  ? 324  VAL A C   1 
ATOM   388  O  O   . VAL A 1 61  ? -23.405 -59.318 -7.183  1.00 28.27  ? 324  VAL A O   1 
ATOM   389  C  CB  . VAL A 1 61  ? -26.246 -57.382 -7.080  1.00 26.95  ? 324  VAL A CB  1 
ATOM   390  C  CG1 . VAL A 1 61  ? -26.516 -58.154 -8.342  1.00 26.03  ? 324  VAL A CG1 1 
ATOM   391  C  CG2 . VAL A 1 61  ? -27.486 -57.347 -6.200  1.00 25.10  ? 324  VAL A CG2 1 
ATOM   392  N  N   . VAL A 1 62  ? -23.063 -57.144 -7.552  1.00 28.87  ? 325  VAL A N   1 
ATOM   393  C  CA  . VAL A 1 62  ? -21.810 -57.318 -8.350  1.00 29.78  ? 325  VAL A CA  1 
ATOM   394  C  C   . VAL A 1 62  ? -20.738 -58.020 -7.495  1.00 28.07  ? 325  VAL A C   1 
ATOM   395  O  O   . VAL A 1 62  ? -20.140 -59.010 -7.976  1.00 27.81  ? 325  VAL A O   1 
ATOM   396  C  CB  . VAL A 1 62  ? -21.263 -56.002 -8.916  1.00 27.29  ? 325  VAL A CB  1 
ATOM   397  C  CG1 . VAL A 1 62  ? -19.983 -56.271 -9.674  1.00 26.91  ? 325  VAL A CG1 1 
ATOM   398  C  CG2 . VAL A 1 62  ? -22.276 -55.308 -9.816  1.00 29.50  ? 325  VAL A CG2 1 
ATOM   399  N  N   . ARG A 1 63  ? -20.507 -57.573 -6.268  1.00 25.89  ? 326  ARG A N   1 
ATOM   400  C  CA  . ARG A 1 63  ? -19.446 -58.194 -5.443  1.00 25.65  ? 326  ARG A CA  1 
ATOM   401  C  C   . ARG A 1 63  ? -19.757 -59.674 -5.207  1.00 26.79  ? 326  ARG A C   1 
ATOM   402  O  O   . ARG A 1 63  ? -18.824 -60.467 -5.329  1.00 26.83  ? 326  ARG A O   1 
ATOM   403  C  CB  . ARG A 1 63  ? -19.193 -57.463 -4.132  1.00 24.27  ? 326  ARG A CB  1 
ATOM   404  C  CG  . ARG A 1 63  ? -18.229 -58.211 -3.224  1.00 26.24  ? 326  ARG A CG  1 
ATOM   405  C  CD  . ARG A 1 63  ? -17.452 -57.269 -2.334  1.00 25.84  ? 326  ARG A CD  1 
ATOM   406  N  NE  . ARG A 1 63  ? -18.372 -56.744 -1.341  1.00 27.77  ? 326  ARG A NE  1 
ATOM   407  C  CZ  . ARG A 1 63  ? -17.990 -55.972 -0.334  1.00 28.87  ? 326  ARG A CZ  1 
ATOM   408  N  NH1 . ARG A 1 63  ? -16.721 -55.613 -0.229  1.00 29.44  ? 326  ARG A NH1 1 
ATOM   409  N  NH2 . ARG A 1 63  ? -18.875 -55.471 0.501   1.00 28.15  ? 326  ARG A NH2 1 
ATOM   410  N  N   . LEU A 1 64  ? -20.972 -60.070 -4.851  1.00 26.41  ? 327  LEU A N   1 
ATOM   411  C  CA  . LEU A 1 64  ? -21.224 -61.515 -4.568  1.00 28.96  ? 327  LEU A CA  1 
ATOM   412  C  C   . LEU A 1 64  ? -20.983 -62.350 -5.837  1.00 28.91  ? 327  LEU A C   1 
ATOM   413  O  O   . LEU A 1 64  ? -20.677 -63.575 -5.706  1.00 28.95  ? 327  LEU A O   1 
ATOM   414  C  CB  . LEU A 1 64  ? -22.655 -61.731 -4.054  1.00 31.95  ? 327  LEU A CB  1 
ATOM   415  C  CG  . LEU A 1 64  ? -22.913 -61.458 -2.563  1.00 31.60  ? 327  LEU A CG  1 
ATOM   416  C  CD1 . LEU A 1 64  ? -24.386 -61.671 -2.228  1.00 33.82  ? 327  LEU A CD1 1 
ATOM   417  C  CD2 . LEU A 1 64  ? -22.075 -62.314 -1.648  1.00 33.62  ? 327  LEU A CD2 1 
ATOM   418  N  N   . LEU A 1 65  ? -21.104 -61.765 -7.039  1.00 27.05  ? 328  LEU A N   1 
ATOM   419  C  CA  . LEU A 1 65  ? -20.940 -62.576 -8.286  1.00 27.80  ? 328  LEU A CA  1 
ATOM   420  C  C   . LEU A 1 65  ? -19.534 -62.410 -8.864  1.00 29.35  ? 328  LEU A C   1 
ATOM   421  O  O   . LEU A 1 65  ? -19.298 -62.970 -9.935  1.00 25.18  ? 328  LEU A O   1 
ATOM   422  C  CB  . LEU A 1 65  ? -22.040 -62.256 -9.301  1.00 30.95  ? 328  LEU A CB  1 
ATOM   423  C  CG  . LEU A 1 65  ? -23.459 -62.514 -8.789  1.00 29.35  ? 328  LEU A CG  1 
ATOM   424  C  CD1 . LEU A 1 65  ? -24.522 -61.961 -9.709  1.00 31.03  ? 328  LEU A CD1 1 
ATOM   425  C  CD2 . LEU A 1 65  ? -23.677 -63.991 -8.597  1.00 33.98  ? 328  LEU A CD2 1 
ATOM   426  N  N   . THR A 1 66  ? -18.623 -61.747 -8.134  1.00 26.21  ? 329  THR A N   1 
ATOM   427  C  CA  . THR A 1 66  ? -17.207 -61.586 -8.531  1.00 26.45  ? 329  THR A CA  1 
ATOM   428  C  C   . THR A 1 66  ? -16.275 -61.928 -7.348  1.00 26.23  ? 329  THR A C   1 
ATOM   429  O  O   . THR A 1 66  ? -15.263 -61.251 -7.161  1.00 28.74  ? 329  THR A O   1 
ATOM   430  C  CB  . THR A 1 66  ? -16.965 -60.191 -9.144  1.00 27.65  ? 329  THR A CB  1 
ATOM   431  O  OG1 . THR A 1 66  ? -17.401 -59.172 -8.234  1.00 21.82  ? 329  THR A OG1 1 
ATOM   432  C  CG2 . THR A 1 66  ? -17.588 -60.047 -10.524 1.00 25.58  ? 329  THR A CG2 1 
ATOM   433  N  N   . LYS A 1 67  ? -16.495 -63.049 -6.684  1.00 25.58  ? 330  LYS A N   1 
ATOM   434  C  CA  . LYS A 1 67  ? -15.777 -63.456 -5.450  1.00 26.62  ? 330  LYS A CA  1 
ATOM   435  C  C   . LYS A 1 67  ? -14.256 -63.556 -5.625  1.00 27.50  ? 330  LYS A C   1 
ATOM   436  O  O   . LYS A 1 67  ? -13.515 -63.140 -4.730  1.00 29.44  ? 330  LYS A O   1 
ATOM   437  C  CB  . LYS A 1 67  ? -16.341 -64.787 -4.968  1.00 29.52  ? 330  LYS A CB  1 
ATOM   438  C  CG  . LYS A 1 67  ? -15.826 -65.216 -3.625  1.00 30.32  ? 330  LYS A CG  1 
ATOM   439  C  CD  . LYS A 1 67  ? -16.286 -66.571 -3.228  1.00 33.14  ? 330  LYS A CD  1 
ATOM   440  C  CE  . LYS A 1 67  ? -16.379 -66.617 -1.719  1.00 38.93  ? 330  LYS A CE  1 
ATOM   441  N  NZ  . LYS A 1 67  ? -16.112 -67.987 -1.253  1.00 45.22  ? 330  LYS A NZ  1 
ATOM   442  N  N   . PRO A 1 68  ? -13.704 -64.117 -6.711  1.00 24.17  ? 331  PRO A N   1 
ATOM   443  C  CA  . PRO A 1 68  ? -12.260 -64.210 -6.855  1.00 28.27  ? 331  PRO A CA  1 
ATOM   444  C  C   . PRO A 1 68  ? -11.579 -62.848 -6.660  1.00 31.06  ? 331  PRO A C   1 
ATOM   445  O  O   . PRO A 1 68  ? -10.427 -62.810 -6.224  1.00 25.74  ? 331  PRO A O   1 
ATOM   446  C  CB  . PRO A 1 68  ? -12.023 -64.723 -8.289  1.00 27.55  ? 331  PRO A CB  1 
ATOM   447  C  CG  . PRO A 1 68  ? -13.286 -65.485 -8.586  1.00 29.33  ? 331  PRO A CG  1 
ATOM   448  C  CD  . PRO A 1 68  ? -14.397 -64.754 -7.832  1.00 30.04  ? 331  PRO A CD  1 
ATOM   449  N  N   . TRP A 1 69  ? -12.289 -61.759 -6.959  1.00 28.50  ? 332  TRP A N   1 
ATOM   450  C  CA  . TRP A 1 69  ? -11.684 -60.410 -6.889  1.00 30.42  ? 332  TRP A CA  1 
ATOM   451  C  C   . TRP A 1 69  ? -11.729 -59.900 -5.446  1.00 29.36  ? 332  TRP A C   1 
ATOM   452  O  O   . TRP A 1 69  ? -11.151 -58.861 -5.203  1.00 31.42  ? 332  TRP A O   1 
ATOM   453  C  CB  . TRP A 1 69  ? -12.347 -59.491 -7.930  1.00 31.52  ? 332  TRP A CB  1 
ATOM   454  C  CG  . TRP A 1 69  ? -11.947 -59.898 -9.310  1.00 26.76  ? 332  TRP A CG  1 
ATOM   455  C  CD1 . TRP A 1 69  ? -10.866 -59.432 -9.989  1.00 27.80  ? 332  TRP A CD1 1 
ATOM   456  C  CD2 . TRP A 1 69  ? -12.558 -60.885 -10.155 1.00 26.96  ? 332  TRP A CD2 1 
ATOM   457  N  NE1 . TRP A 1 69  ? -10.734 -60.090 -11.182 1.00 28.89  ? 332  TRP A NE1 1 
ATOM   458  C  CE2 . TRP A 1 69  ? -11.763 -60.983 -11.316 1.00 28.94  ? 332  TRP A CE2 1 
ATOM   459  C  CE3 . TRP A 1 69  ? -13.677 -61.716 -10.056 1.00 28.90  ? 332  TRP A CE3 1 
ATOM   460  C  CZ2 . TRP A 1 69  ? -12.054 -61.860 -12.360 1.00 28.93  ? 332  TRP A CZ2 1 
ATOM   461  C  CZ3 . TRP A 1 69  ? -13.967 -62.580 -11.091 1.00 28.37  ? 332  TRP A CZ3 1 
ATOM   462  C  CH2 . TRP A 1 69  ? -13.160 -62.654 -12.220 1.00 27.09  ? 332  TRP A CH2 1 
ATOM   463  N  N   . ASP A 1 70  ? -12.291 -60.655 -4.490  1.00 30.12  ? 333  ASP A N   1 
ATOM   464  C  CA  . ASP A 1 70  ? -12.355 -60.202 -3.068  1.00 27.39  ? 333  ASP A CA  1 
ATOM   465  C  C   . ASP A 1 70  ? -10.946 -60.107 -2.481  1.00 27.25  ? 333  ASP A C   1 
ATOM   466  O  O   . ASP A 1 70  ? -10.791 -59.401 -1.448  1.00 30.46  ? 333  ASP A O   1 
ATOM   467  C  CB  . ASP A 1 70  ? -13.265 -61.093 -2.225  1.00 29.90  ? 333  ASP A CB  1 
ATOM   468  C  CG  . ASP A 1 70  ? -14.741 -60.934 -2.554  1.00 30.19  ? 333  ASP A CG  1 
ATOM   469  O  OD1 . ASP A 1 70  ? -15.084 -60.051 -3.383  1.00 28.61  ? 333  ASP A OD1 1 
ATOM   470  O  OD2 . ASP A 1 70  ? -15.527 -61.719 -2.001  1.00 31.55  ? 333  ASP A OD2 1 
ATOM   471  N  N   . ILE A 1 71  ? -9.962  -60.738 -3.129  1.00 28.96  ? 334  ILE A N   1 
ATOM   472  C  CA  . ILE A 1 71  ? -8.552  -60.836 -2.641  1.00 29.10  ? 334  ILE A CA  1 
ATOM   473  C  C   . ILE A 1 71  ? -7.565  -60.100 -3.571  1.00 33.57  ? 334  ILE A C   1 
ATOM   474  O  O   . ILE A 1 71  ? -6.355  -60.274 -3.340  1.00 37.53  ? 334  ILE A O   1 
ATOM   475  C  CB  . ILE A 1 71  ? -8.142  -62.299 -2.392  1.00 29.25  ? 334  ILE A CB  1 
ATOM   476  C  CG1 . ILE A 1 71  ? -8.199  -63.168 -3.650  1.00 33.62  ? 334  ILE A CG1 1 
ATOM   477  C  CG2 . ILE A 1 71  ? -8.951  -62.912 -1.263  1.00 30.53  ? 334  ILE A CG2 1 
ATOM   478  C  CD1 . ILE A 1 71  ? -7.491  -64.483 -3.495  1.00 37.44  ? 334  ILE A CD1 1 
ATOM   479  N  N   . ILE A 1 72  ? -8.032  -59.289 -4.535  1.00 31.44  ? 335  ILE A N   1 
ATOM   480  C  CA  . ILE A 1 72  ? -7.196  -58.494 -5.472  1.00 28.73  ? 335  ILE A CA  1 
ATOM   481  C  C   . ILE A 1 72  ? -7.196  -57.061 -4.956  1.00 33.59  ? 335  ILE A C   1 
ATOM   482  O  O   . ILE A 1 72  ? -8.205  -56.365 -5.094  1.00 31.79  ? 335  ILE A O   1 
ATOM   483  C  CB  . ILE A 1 72  ? -7.753  -58.539 -6.906  1.00 34.34  ? 335  ILE A CB  1 
ATOM   484  C  CG1 . ILE A 1 72  ? -7.950  -59.962 -7.444  1.00 34.16  ? 335  ILE A CG1 1 
ATOM   485  C  CG2 . ILE A 1 72  ? -6.918  -57.660 -7.844  1.00 34.50  ? 335  ILE A CG2 1 
ATOM   486  C  CD1 . ILE A 1 72  ? -6.698  -60.740 -7.629  1.00 37.90  ? 335  ILE A CD1 1 
ATOM   487  N  N   . PRO A 1 73  ? -6.088  -56.575 -4.341  1.00 36.13  ? 336  PRO A N   1 
ATOM   488  C  CA  . PRO A 1 73  ? -6.030  -55.221 -3.789  1.00 35.80  ? 336  PRO A CA  1 
ATOM   489  C  C   . PRO A 1 73  ? -6.384  -54.117 -4.797  1.00 36.04  ? 336  PRO A C   1 
ATOM   490  O  O   . PRO A 1 73  ? -7.021  -53.196 -4.443  1.00 37.45  ? 336  PRO A O   1 
ATOM   491  C  CB  . PRO A 1 73  ? -4.552  -55.052 -3.430  1.00 38.46  ? 336  PRO A CB  1 
ATOM   492  C  CG  . PRO A 1 73  ? -4.100  -56.459 -3.140  1.00 38.14  ? 336  PRO A CG  1 
ATOM   493  C  CD  . PRO A 1 73  ? -4.830  -57.314 -4.156  1.00 36.90  ? 336  PRO A CD  1 
ATOM   494  N  N   . MET A 1 74  ? -5.996  -54.257 -6.055  1.00 37.90  ? 337  MET A N   1 
ATOM   495  C  CA  . MET A 1 74  ? -6.299  -53.225 -7.074  1.00 39.00  ? 337  MET A CA  1 
ATOM   496  C  C   . MET A 1 74  ? -7.820  -53.021 -7.154  1.00 37.60  ? 337  MET A C   1 
ATOM   497  O  O   . MET A 1 74  ? -8.226  -51.887 -7.292  1.00 42.23  ? 337  MET A O   1 
ATOM   498  C  CB  . MET A 1 74  ? -5.730  -53.638 -8.431  1.00 45.98  ? 337  MET A CB  1 
ATOM   499  C  CG  . MET A 1 74  ? -4.200  -53.635 -8.472  1.00 56.91  ? 337  MET A CG  1 
ATOM   500  S  SD  . MET A 1 74  ? -3.464  -51.982 -8.084  1.00 73.45  ? 337  MET A SD  1 
ATOM   501  C  CE  . MET A 1 74  ? -4.565  -50.929 -9.035  1.00 65.99  ? 337  MET A CE  1 
ATOM   502  N  N   . VAL A 1 75  ? -8.621  -54.080 -6.993  1.00 32.64  ? 338  VAL A N   1 
ATOM   503  C  CA  . VAL A 1 75  ? -10.120 -54.032 -6.989  1.00 27.20  ? 338  VAL A CA  1 
ATOM   504  C  C   . VAL A 1 75  ? -10.628 -53.532 -5.643  1.00 27.86  ? 338  VAL A C   1 
ATOM   505  O  O   . VAL A 1 75  ? -11.434 -52.621 -5.644  1.00 33.72  ? 338  VAL A O   1 
ATOM   506  C  CB  . VAL A 1 75  ? -10.726 -55.396 -7.342  1.00 27.19  ? 338  VAL A CB  1 
ATOM   507  C  CG1 . VAL A 1 75  ? -12.234 -55.451 -7.038  1.00 28.76  ? 338  VAL A CG1 1 
ATOM   508  C  CG2 . VAL A 1 75  ? -10.446 -55.720 -8.813  1.00 25.79  ? 338  VAL A CG2 1 
ATOM   509  N  N   . THR A 1 76  ? -10.202 -54.120 -4.541  1.00 30.39  ? 339  THR A N   1 
ATOM   510  C  CA  . THR A 1 76  ? -10.769 -53.860 -3.191  1.00 35.73  ? 339  THR A CA  1 
ATOM   511  C  C   . THR A 1 76  ? -10.404 -52.451 -2.711  1.00 34.96  ? 339  THR A C   1 
ATOM   512  O  O   . THR A 1 76  ? -11.271 -51.825 -2.112  1.00 36.30  ? 339  THR A O   1 
ATOM   513  C  CB  . THR A 1 76  ? -10.316 -54.927 -2.190  1.00 38.59  ? 339  THR A CB  1 
ATOM   514  O  OG1 . THR A 1 76  ? -8.888  -54.925 -2.042  1.00 41.03  ? 339  THR A OG1 1 
ATOM   515  C  CG2 . THR A 1 76  ? -10.769 -56.290 -2.661  1.00 41.00  ? 339  THR A CG2 1 
ATOM   516  N  N   . GLN A 1 77  ? -9.219  -51.937 -3.044  1.00 35.90  ? 340  GLN A N   1 
ATOM   517  C  CA  . GLN A 1 77  ? -8.781  -50.593 -2.568  1.00 42.47  ? 340  GLN A CA  1 
ATOM   518  C  C   . GLN A 1 77  ? -9.565  -49.509 -3.303  1.00 38.70  ? 340  GLN A C   1 
ATOM   519  O  O   . GLN A 1 77  ? -9.701  -48.442 -2.719  1.00 36.35  ? 340  GLN A O   1 
ATOM   520  C  CB  . GLN A 1 77  ? -7.292  -50.345 -2.760  1.00 43.31  ? 340  GLN A CB  1 
ATOM   521  C  CG  . GLN A 1 77  ? -6.451  -51.522 -2.331  1.00 54.86  ? 340  GLN A CG  1 
ATOM   522  C  CD  . GLN A 1 77  ? -5.840  -51.371 -0.967  1.00 70.15  ? 340  GLN A CD  1 
ATOM   523  O  OE1 . GLN A 1 77  ? -6.434  -50.779 -0.063  1.00 77.20  ? 340  GLN A OE1 1 
ATOM   524  N  NE2 . GLN A 1 77  ? -4.645  -51.933 -0.820  1.00 74.33  ? 340  GLN A NE2 1 
ATOM   525  N  N   . MET A 1 78  ? -10.063 -49.778 -4.520  1.00 36.61  ? 341  MET A N   1 
ATOM   526  C  CA  . MET A 1 78  ? -10.805 -48.759 -5.308  1.00 37.08  ? 341  MET A CA  1 
ATOM   527  C  C   . MET A 1 78  ? -12.036 -48.331 -4.524  1.00 38.88  ? 341  MET A C   1 
ATOM   528  O  O   . MET A 1 78  ? -12.498 -47.208 -4.760  1.00 37.61  ? 341  MET A O   1 
ATOM   529  C  CB  . MET A 1 78  ? -11.280 -49.236 -6.677  1.00 39.45  ? 341  MET A CB  1 
ATOM   530  C  CG  . MET A 1 78  ? -10.194 -49.252 -7.727  1.00 46.19  ? 341  MET A CG  1 
ATOM   531  S  SD  . MET A 1 78  ? -10.849 -49.650 -9.386  1.00 50.92  ? 341  MET A SD  1 
ATOM   532  C  CE  . MET A 1 78  ? -12.215 -48.497 -9.412  1.00 46.25  ? 341  MET A CE  1 
ATOM   533  N  N   . ALA A 1 79  ? -12.568 -49.167 -3.627  1.00 40.99  ? 342  ALA A N   1 
ATOM   534  C  CA  . ALA A 1 79  ? -13.848 -48.829 -2.954  1.00 40.03  ? 342  ALA A CA  1 
ATOM   535  C  C   . ALA A 1 79  ? -13.607 -48.143 -1.597  1.00 41.33  ? 342  ALA A C   1 
ATOM   536  O  O   . ALA A 1 79  ? -14.597 -47.783 -0.986  1.00 40.20  ? 342  ALA A O   1 
ATOM   537  C  CB  . ALA A 1 79  ? -14.712 -50.064 -2.834  1.00 43.91  ? 342  ALA A CB  1 
ATOM   538  N  N   . MET A 1 80  ? -12.362 -47.939 -1.154  1.00 45.24  ? 343  MET A N   1 
ATOM   539  C  CA  . MET A 1 80  ? -12.041 -47.316 0.167   1.00 55.19  ? 343  MET A CA  1 
ATOM   540  C  C   . MET A 1 80  ? -11.863 -45.796 0.016   1.00 62.77  ? 343  MET A C   1 
ATOM   541  O  O   . MET A 1 80  ? -11.729 -45.336 -1.132  1.00 72.84  ? 343  MET A O   1 
ATOM   542  C  CB  . MET A 1 80  ? -10.750 -47.908 0.751   1.00 51.06  ? 343  MET A CB  1 
ATOM   543  C  CG  . MET A 1 80  ? -10.754 -49.439 0.837   1.00 59.51  ? 343  MET A CG  1 
ATOM   544  S  SD  . MET A 1 80  ? -12.014 -50.217 1.938   1.00 60.22  ? 343  MET A SD  1 
ATOM   545  C  CE  . MET A 1 80  ? -11.743 -49.328 3.478   1.00 54.68  ? 343  MET A CE  1 
ATOM   546  N  N   . THR A 1 81  ? -11.829 -45.055 1.133   1.00 73.37  ? 344  THR A N   1 
ATOM   547  C  CA  . THR A 1 81  ? -11.203 -43.712 1.232   1.00 70.26  ? 344  THR A CA  1 
ATOM   548  C  C   . THR A 1 81  ? -12.000 -42.761 2.101   1.00 63.48  ? 344  THR A C   1 
ATOM   549  O  O   . THR A 1 81  ? -13.209 -42.634 1.807   1.00 66.16  ? 344  THR A O   1 
ATOM   550  N  N   . GLU A 1 94  ? -3.931  -28.147 -4.100  0.26 77.73  ? 357  GLU A N   1 
ATOM   551  C  CA  . GLU A 1 94  ? -2.788  -27.197 -4.182  0.26 78.62  ? 357  GLU A CA  1 
ATOM   552  C  C   . GLU A 1 94  ? -2.350  -27.049 -5.647  0.26 79.09  ? 357  GLU A C   1 
ATOM   553  O  O   . GLU A 1 94  ? -1.215  -26.585 -5.880  0.26 76.08  ? 357  GLU A O   1 
ATOM   554  C  CB  . GLU A 1 94  ? -1.645  -27.672 -3.279  0.26 77.62  ? 357  GLU A CB  1 
ATOM   555  C  CG  . GLU A 1 94  ? -1.928  -27.487 -1.797  0.26 77.75  ? 357  GLU A CG  1 
ATOM   556  C  CD  . GLU A 1 94  ? -3.199  -28.155 -1.297  0.26 77.70  ? 357  GLU A CD  1 
ATOM   557  O  OE1 . GLU A 1 94  ? -3.925  -27.526 -0.501  0.26 75.00  ? 357  GLU A OE1 1 
ATOM   558  O  OE2 . GLU A 1 94  ? -3.461  -29.303 -1.706  0.26 79.15  ? 357  GLU A OE2 1 
ATOM   559  N  N   . LYS A 1 95  ? -3.223  -27.429 -6.589  0.26 81.61  ? 358  LYS A N   1 
ATOM   560  C  CA  . LYS A 1 95  ? -3.053  -27.215 -8.054  0.26 81.99  ? 358  LYS A CA  1 
ATOM   561  C  C   . LYS A 1 95  ? -4.041  -26.150 -8.546  0.26 81.68  ? 358  LYS A C   1 
ATOM   562  O  O   . LYS A 1 95  ? -3.685  -25.411 -9.485  0.26 79.47  ? 358  LYS A O   1 
ATOM   563  C  CB  . LYS A 1 95  ? -3.261  -28.523 -8.822  0.26 81.35  ? 358  LYS A CB  1 
ATOM   564  C  CG  . LYS A 1 95  ? -3.031  -28.417 -10.324 0.26 80.10  ? 358  LYS A CG  1 
ATOM   565  C  CD  . LYS A 1 95  ? -2.596  -29.713 -10.970 0.26 79.15  ? 358  LYS A CD  1 
ATOM   566  C  CE  . LYS A 1 95  ? -1.689  -29.497 -12.163 0.26 77.60  ? 358  LYS A CE  1 
ATOM   567  N  NZ  . LYS A 1 95  ? -1.007  -30.751 -12.559 0.26 76.19  ? 358  LYS A NZ  1 
ATOM   568  N  N   . VAL A 1 96  ? -5.241  -26.094 -7.956  0.26 83.65  ? 359  VAL A N   1 
ATOM   569  C  CA  . VAL A 1 96  ? -6.282  -25.064 -8.258  0.26 85.30  ? 359  VAL A CA  1 
ATOM   570  C  C   . VAL A 1 96  ? -5.739  -23.681 -7.869  0.26 85.51  ? 359  VAL A C   1 
ATOM   571  O  O   . VAL A 1 96  ? -6.026  -22.713 -8.602  0.26 85.14  ? 359  VAL A O   1 
ATOM   572  C  CB  . VAL A 1 96  ? -7.621  -25.379 -7.558  0.26 85.39  ? 359  VAL A CB  1 
ATOM   573  C  CG1 . VAL A 1 96  ? -7.550  -25.196 -6.048  0.26 86.85  ? 359  VAL A CG1 1 
ATOM   574  C  CG2 . VAL A 1 96  ? -8.764  -24.563 -8.140  0.26 84.20  ? 359  VAL A CG2 1 
ATOM   575  N  N   . ASP A 1 97  ? -4.965  -23.600 -6.779  0.26 85.60  ? 360  ASP A N   1 
ATOM   576  C  CA  . ASP A 1 97  ? -4.358  -22.344 -6.259  0.26 86.62  ? 360  ASP A CA  1 
ATOM   577  C  C   . ASP A 1 97  ? -2.966  -22.162 -6.886  0.26 89.74  ? 360  ASP A C   1 
ATOM   578  O  O   . ASP A 1 97  ? -1.998  -21.938 -6.129  0.26 91.04  ? 360  ASP A O   1 
ATOM   579  C  CB  . ASP A 1 97  ? -4.332  -22.356 -4.725  0.26 84.81  ? 360  ASP A CB  1 
ATOM   580  C  CG  . ASP A 1 97  ? -4.317  -20.982 -4.068  0.26 82.61  ? 360  ASP A CG  1 
ATOM   581  O  OD1 . ASP A 1 97  ? -4.052  -19.986 -4.772  0.26 80.55  ? 360  ASP A OD1 1 
ATOM   582  O  OD2 . ASP A 1 97  ? -4.574  -20.918 -2.851  0.26 81.12  ? 360  ASP A OD2 1 
ATOM   583  N  N   . THR A 1 98  ? -2.878  -22.252 -8.220  0.26 93.16  ? 361  THR A N   1 
ATOM   584  C  CA  . THR A 1 98  ? -1.664  -21.964 -9.035  0.26 95.86  ? 361  THR A CA  1 
ATOM   585  C  C   . THR A 1 98  ? -1.979  -20.811 -9.996  0.26 98.91  ? 361  THR A C   1 
ATOM   586  O  O   . THR A 1 98  ? -3.164  -20.431 -10.088 0.26 98.34  ? 361  THR A O   1 
ATOM   587  C  CB  . THR A 1 98  ? -1.176  -23.209 -9.789  0.26 95.55  ? 361  THR A CB  1 
ATOM   588  O  OG1 . THR A 1 98  ? -2.232  -23.673 -10.632 0.26 94.02  ? 361  THR A OG1 1 
ATOM   589  C  CG2 . THR A 1 98  ? -0.731  -24.320 -8.863  0.26 95.94  ? 361  THR A CG2 1 
ATOM   590  N  N   . ARG A 1 99  ? -0.938  -20.278 -10.649 1.00 105.09 ? 362  ARG A N   1 
ATOM   591  C  CA  . ARG A 1 99  ? -1.123  -19.099 -11.537 1.00 108.81 ? 362  ARG A CA  1 
ATOM   592  C  C   . ARG A 1 99  ? -0.352  -19.268 -12.849 1.00 105.13 ? 362  ARG A C   1 
ATOM   593  O  O   . ARG A 1 99  ? 0.883   -19.364 -12.791 1.00 113.73 ? 362  ARG A O   1 
ATOM   594  C  CB  . ARG A 1 99  ? -0.699  -17.814 -10.817 1.00 116.57 ? 362  ARG A CB  1 
ATOM   595  C  CG  . ARG A 1 99  ? -1.513  -16.590 -11.208 1.00 118.19 ? 362  ARG A CG  1 
ATOM   596  C  CD  . ARG A 1 99  ? -0.660  -15.338 -11.271 1.00 125.57 ? 362  ARG A CD  1 
ATOM   597  N  NE  . ARG A 1 99  ? 0.327   -15.425 -12.338 1.00 132.55 ? 362  ARG A NE  1 
ATOM   598  C  CZ  . ARG A 1 99  ? 1.190   -14.465 -12.646 1.00 124.86 ? 362  ARG A CZ  1 
ATOM   599  N  NH1 . ARG A 1 99  ? 1.194   -13.334 -11.964 1.00 128.45 ? 362  ARG A NH1 1 
ATOM   600  N  NH2 . ARG A 1 99  ? 2.046   -14.641 -13.635 1.00 115.27 ? 362  ARG A NH2 1 
ATOM   601  N  N   . THR A 1 100 ? -1.057  -19.285 -13.975 0.26 103.41 ? 363  THR A N   1 
ATOM   602  C  CA  . THR A 1 100 ? -0.493  -19.388 -15.349 0.26 101.40 ? 363  THR A CA  1 
ATOM   603  C  C   . THR A 1 100 ? -0.111  -17.989 -15.842 0.26 98.40  ? 363  THR A C   1 
ATOM   604  O  O   . THR A 1 100 ? -0.898  -17.049 -15.614 0.26 98.10  ? 363  THR A O   1 
ATOM   605  C  CB  . THR A 1 100 ? -1.472  -20.067 -16.316 0.26 103.37 ? 363  THR A CB  1 
ATOM   606  O  OG1 . THR A 1 100 ? -1.861  -21.318 -15.749 0.26 104.66 ? 363  THR A OG1 1 
ATOM   607  C  CG2 . THR A 1 100 ? -0.879  -20.292 -17.691 0.26 103.36 ? 363  THR A CG2 1 
ATOM   608  N  N   . GLN A 1 101 ? 1.048   -17.875 -16.497 1.00 98.59  ? 364  GLN A N   1 
ATOM   609  C  CA  . GLN A 1 101 ? 1.577   -16.590 -17.033 1.00 93.05  ? 364  GLN A CA  1 
ATOM   610  C  C   . GLN A 1 101 ? 0.873   -16.247 -18.353 1.00 82.48  ? 364  GLN A C   1 
ATOM   611  O  O   . GLN A 1 101 ? 0.389   -17.160 -19.048 1.00 81.33  ? 364  GLN A O   1 
ATOM   612  C  CB  . GLN A 1 101 ? 3.093   -16.684 -17.256 1.00 95.50  ? 364  GLN A CB  1 
ATOM   613  C  CG  . GLN A 1 101 ? 3.734   -15.357 -17.662 1.00 107.37 ? 364  GLN A CG  1 
ATOM   614  C  CD  . GLN A 1 101 ? 5.239   -15.401 -17.775 1.00 110.87 ? 364  GLN A CD  1 
ATOM   615  O  OE1 . GLN A 1 101 ? 5.820   -16.392 -18.209 1.00 113.78 ? 364  GLN A OE1 1 
ATOM   616  N  NE2 . GLN A 1 101 ? 5.883   -14.303 -17.408 1.00 106.62 ? 364  GLN A NE2 1 
ATOM   617  N  N   . GLU A 1 102 ? 0.814   -14.952 -18.682 0.26 78.16  ? 365  GLU A N   1 
ATOM   618  C  CA  . GLU A 1 102 ? 0.299   -14.443 -19.981 0.26 74.89  ? 365  GLU A CA  1 
ATOM   619  C  C   . GLU A 1 102 ? 1.249   -14.905 -21.084 0.26 70.68  ? 365  GLU A C   1 
ATOM   620  O  O   . GLU A 1 102 ? 2.445   -14.627 -21.030 0.26 70.39  ? 365  GLU A O   1 
ATOM   621  C  CB  . GLU A 1 102 ? 0.165   -12.917 -19.949 0.26 75.39  ? 365  GLU A CB  1 
ATOM   622  C  CG  . GLU A 1 102 ? -0.597  -12.333 -21.131 0.26 76.19  ? 365  GLU A CG  1 
ATOM   623  C  CD  . GLU A 1 102 ? -2.111  -12.479 -21.087 0.26 75.97  ? 365  GLU A CD  1 
ATOM   624  O  OE1 . GLU A 1 102 ? -2.790  -11.812 -21.896 0.26 75.51  ? 365  GLU A OE1 1 
ATOM   625  O  OE2 . GLU A 1 102 ? -2.612  -13.258 -20.253 0.26 75.00  ? 365  GLU A OE2 1 
ATOM   626  N  N   . PRO A 1 103 ? 0.757   -15.642 -22.106 1.00 67.42  ? 366  PRO A N   1 
ATOM   627  C  CA  . PRO A 1 103 ? 1.595   -16.031 -23.236 1.00 61.91  ? 366  PRO A CA  1 
ATOM   628  C  C   . PRO A 1 103 ? 2.220   -14.827 -23.952 1.00 55.71  ? 366  PRO A C   1 
ATOM   629  O  O   . PRO A 1 103 ? 1.698   -13.745 -23.856 1.00 52.65  ? 366  PRO A O   1 
ATOM   630  C  CB  . PRO A 1 103 ? 0.612   -16.713 -24.208 1.00 60.50  ? 366  PRO A CB  1 
ATOM   631  C  CG  . PRO A 1 103 ? -0.579  -17.107 -23.361 1.00 62.45  ? 366  PRO A CG  1 
ATOM   632  C  CD  . PRO A 1 103 ? -0.634  -16.118 -22.214 1.00 65.63  ? 366  PRO A CD  1 
ATOM   633  N  N   . LYS A 1 104 ? 3.305   -15.076 -24.695 0.26 56.84  ? 367  LYS A N   1 
ATOM   634  C  CA  . LYS A 1 104 ? 4.001   -14.079 -25.556 0.26 57.10  ? 367  LYS A CA  1 
ATOM   635  C  C   . LYS A 1 104 ? 3.028   -13.557 -26.623 0.26 56.12  ? 367  LYS A C   1 
ATOM   636  O  O   . LYS A 1 104 ? 1.980   -14.197 -26.842 0.26 55.42  ? 367  LYS A O   1 
ATOM   637  C  CB  . LYS A 1 104 ? 5.223   -14.689 -26.252 0.26 58.68  ? 367  LYS A CB  1 
ATOM   638  C  CG  . LYS A 1 104 ? 6.207   -15.452 -25.371 0.26 59.50  ? 367  LYS A CG  1 
ATOM   639  C  CD  . LYS A 1 104 ? 6.565   -14.763 -24.079 0.26 60.52  ? 367  LYS A CD  1 
ATOM   640  C  CE  . LYS A 1 104 ? 7.672   -15.474 -23.331 0.26 62.12  ? 367  LYS A CE  1 
ATOM   641  N  NZ  . LYS A 1 104 ? 7.786   -14.983 -21.937 0.26 63.49  ? 367  LYS A NZ  1 
ATOM   642  N  N   . GLU A 1 105 ? 3.386   -12.448 -27.277 0.26 55.78  ? 368  GLU A N   1 
ATOM   643  C  CA  . GLU A 1 105 ? 2.560   -11.768 -28.312 0.26 56.34  ? 368  GLU A CA  1 
ATOM   644  C  C   . GLU A 1 105 ? 2.361   -12.705 -29.511 0.26 54.87  ? 368  GLU A C   1 
ATOM   645  O  O   . GLU A 1 105 ? 1.234   -12.747 -30.041 0.26 54.91  ? 368  GLU A O   1 
ATOM   646  C  CB  . GLU A 1 105 ? 3.222   -10.456 -28.745 0.26 57.92  ? 368  GLU A CB  1 
ATOM   647  C  CG  . GLU A 1 105 ? 3.221   -9.387  -27.665 0.26 57.74  ? 368  GLU A CG  1 
ATOM   648  C  CD  . GLU A 1 105 ? 1.855   -8.793  -27.367 0.26 58.35  ? 368  GLU A CD  1 
ATOM   649  O  OE1 . GLU A 1 105 ? 1.166   -8.388  -28.329 0.26 57.14  ? 368  GLU A OE1 1 
ATOM   650  O  OE2 . GLU A 1 105 ? 1.480   -8.745  -26.176 0.26 59.18  ? 368  GLU A OE2 1 
ATOM   651  N  N   . GLY A 1 106 ? 3.417   -13.422 -29.913 1.00 53.91  ? 369  GLY A N   1 
ATOM   652  C  CA  . GLY A 1 106 ? 3.381   -14.349 -31.065 1.00 51.59  ? 369  GLY A CA  1 
ATOM   653  C  C   . GLY A 1 106 ? 2.418   -15.506 -30.805 1.00 53.88  ? 369  GLY A C   1 
ATOM   654  O  O   . GLY A 1 106 ? 1.616   -15.813 -31.717 1.00 51.26  ? 369  GLY A O   1 
ATOM   655  N  N   . THR A 1 107 ? 2.498   -16.113 -29.610 1.00 44.20  ? 370  THR A N   1 
ATOM   656  C  CA  . THR A 1 107 ? 1.582   -17.160 -29.115 1.00 47.53  ? 370  THR A CA  1 
ATOM   657  C  C   . THR A 1 107 ? 0.127   -16.663 -29.207 1.00 52.74  ? 370  THR A C   1 
ATOM   658  O  O   . THR A 1 107 ? -0.690  -17.309 -29.947 1.00 47.96  ? 370  THR A O   1 
ATOM   659  C  CB  . THR A 1 107 ? 1.963   -17.578 -27.693 1.00 47.67  ? 370  THR A CB  1 
ATOM   660  O  OG1 . THR A 1 107 ? 3.366   -17.828 -27.655 1.00 42.13  ? 370  THR A OG1 1 
ATOM   661  C  CG2 . THR A 1 107 ? 1.222   -18.821 -27.254 1.00 48.87  ? 370  THR A CG2 1 
ATOM   662  N  N   . LYS A 1 108 ? -0.178  -15.553 -28.521 1.00 53.90  ? 371  LYS A N   1 
ATOM   663  C  CA  . LYS A 1 108 ? -1.501  -14.850 -28.523 1.00 52.21  ? 371  LYS A CA  1 
ATOM   664  C  C   . LYS A 1 108 ? -2.084  -14.637 -29.937 1.00 46.89  ? 371  LYS A C   1 
ATOM   665  O  O   . LYS A 1 108 ? -3.280  -14.828 -30.120 1.00 44.82  ? 371  LYS A O   1 
ATOM   666  C  CB  . LYS A 1 108 ? -1.394  -13.518 -27.769 1.00 51.59  ? 371  LYS A CB  1 
ATOM   667  C  CG  . LYS A 1 108 ? -1.322  -13.666 -26.259 1.00 53.36  ? 371  LYS A CG  1 
ATOM   668  C  CD  . LYS A 1 108 ? -1.675  -12.431 -25.475 1.00 54.18  ? 371  LYS A CD  1 
ATOM   669  C  CE  . LYS A 1 108 ? -0.573  -11.399 -25.505 1.00 66.91  ? 371  LYS A CE  1 
ATOM   670  N  NZ  . LYS A 1 108 ? -0.593  -10.541 -24.293 1.00 79.19  ? 371  LYS A NZ  1 
ATOM   671  N  N   . LYS A 1 109 ? -1.242  -14.259 -30.903 0.26 48.12  ? 372  LYS A N   1 
ATOM   672  C  CA  . LYS A 1 109 ? -1.651  -14.008 -32.312 0.26 51.14  ? 372  LYS A CA  1 
ATOM   673  C  C   . LYS A 1 109 ? -2.004  -15.339 -32.993 0.26 52.48  ? 372  LYS A C   1 
ATOM   674  O  O   . LYS A 1 109 ? -3.017  -15.372 -33.729 0.26 52.59  ? 372  LYS A O   1 
ATOM   675  C  CB  . LYS A 1 109 ? -0.539  -13.267 -33.065 0.26 53.05  ? 372  LYS A CB  1 
ATOM   676  C  CG  . LYS A 1 109 ? -0.898  -12.779 -34.465 0.26 55.62  ? 372  LYS A CG  1 
ATOM   677  C  CD  . LYS A 1 109 ? -1.950  -11.680 -34.501 0.26 57.29  ? 372  LYS A CD  1 
ATOM   678  C  CE  . LYS A 1 109 ? -1.432  -10.334 -34.035 0.26 58.97  ? 372  LYS A CE  1 
ATOM   679  N  NZ  . LYS A 1 109 ? -2.509  -9.318  -33.979 0.26 58.95  ? 372  LYS A NZ  1 
ATOM   680  N  N   . LEU A 1 110 ? -1.194  -16.382 -32.764 1.00 54.16  ? 373  LEU A N   1 
ATOM   681  C  CA  . LEU A 1 110 ? -1.408  -17.759 -33.323 1.00 50.52  ? 373  LEU A CA  1 
ATOM   682  C  C   . LEU A 1 110 ? -2.735  -18.315 -32.794 1.00 40.35  ? 373  LEU A C   1 
ATOM   683  O  O   . LEU A 1 110 ? -3.488  -18.871 -33.592 1.00 37.07  ? 373  LEU A O   1 
ATOM   684  C  CB  . LEU A 1 110 ? -0.271  -18.702 -32.901 1.00 49.78  ? 373  LEU A CB  1 
ATOM   685  C  CG  . LEU A 1 110 ? 1.094   -18.484 -33.556 1.00 52.19  ? 373  LEU A CG  1 
ATOM   686  C  CD1 . LEU A 1 110 ? 2.199   -19.123 -32.717 1.00 46.99  ? 373  LEU A CD1 1 
ATOM   687  C  CD2 . LEU A 1 110 ? 1.109   -19.009 -34.992 1.00 51.18  ? 373  LEU A CD2 1 
ATOM   688  N  N   . MET A 1 111 ? -3.000  -18.128 -31.503 1.00 35.24  ? 374  MET A N   1 
ATOM   689  C  CA  . MET A 1 111 ? -4.245  -18.583 -30.825 1.00 41.91  ? 374  MET A CA  1 
ATOM   690  C  C   . MET A 1 111 ? -5.482  -17.858 -31.412 1.00 45.30  ? 374  MET A C   1 
ATOM   691  O  O   . MET A 1 111 ? -6.457  -18.574 -31.819 1.00 40.70  ? 374  MET A O   1 
ATOM   692  C  CB  . MET A 1 111 ? -4.144  -18.375 -29.304 1.00 38.81  ? 374  MET A CB  1 
ATOM   693  C  CG  . MET A 1 111 ? -3.119  -19.306 -28.660 1.00 39.72  ? 374  MET A CG  1 
ATOM   694  S  SD  . MET A 1 111 ? -3.341  -19.613 -26.887 1.00 44.87  ? 374  MET A SD  1 
ATOM   695  C  CE  . MET A 1 111 ? -2.913  -18.019 -26.208 1.00 42.66  ? 374  MET A CE  1 
ATOM   696  N  N   . LYS A 1 112 ? -5.463  -16.527 -31.491 1.00 42.29  ? 375  LYS A N   1 
ATOM   697  C  CA  . LYS A 1 112 ? -6.611  -15.753 -32.032 1.00 48.27  ? 375  LYS A CA  1 
ATOM   698  C  C   . LYS A 1 112 ? -6.880  -16.136 -33.496 1.00 43.54  ? 375  LYS A C   1 
ATOM   699  O  O   . LYS A 1 112 ? -8.044  -16.318 -33.836 1.00 41.95  ? 375  LYS A O   1 
ATOM   700  C  CB  . LYS A 1 112 ? -6.356  -14.247 -31.917 1.00 54.93  ? 375  LYS A CB  1 
ATOM   701  C  CG  . LYS A 1 112 ? -7.482  -13.424 -31.307 1.00 61.82  ? 375  LYS A CG  1 
ATOM   702  C  CD  . LYS A 1 112 ? -7.379  -13.306 -29.802 1.00 72.02  ? 375  LYS A CD  1 
ATOM   703  C  CE  . LYS A 1 112 ? -8.533  -12.554 -29.176 1.00 76.06  ? 375  LYS A CE  1 
ATOM   704  N  NZ  . LYS A 1 112 ? -8.442  -12.547 -27.697 1.00 73.22  ? 375  LYS A NZ  1 
ATOM   705  N  N   . ILE A 1 113 ? -5.839  -16.242 -34.319 1.00 40.28  ? 376  ILE A N   1 
ATOM   706  C  CA  . ILE A 1 113 ? -6.040  -16.536 -35.769 1.00 44.37  ? 376  ILE A CA  1 
ATOM   707  C  C   . ILE A 1 113 ? -6.626  -17.936 -35.917 1.00 45.70  ? 376  ILE A C   1 
ATOM   708  O  O   . ILE A 1 113 ? -7.509  -18.130 -36.825 1.00 42.40  ? 376  ILE A O   1 
ATOM   709  C  CB  . ILE A 1 113 ? -4.742  -16.419 -36.588 1.00 46.03  ? 376  ILE A CB  1 
ATOM   710  C  CG1 . ILE A 1 113 ? -4.302  -14.966 -36.771 1.00 57.28  ? 376  ILE A CG1 1 
ATOM   711  C  CG2 . ILE A 1 113 ? -4.895  -17.092 -37.941 1.00 45.08  ? 376  ILE A CG2 1 
ATOM   712  C  CD1 . ILE A 1 113 ? -2.836  -14.813 -37.110 1.00 61.87  ? 376  ILE A CD1 1 
ATOM   713  N  N   . THR A 1 114 ? -6.130  -18.881 -35.100 1.00 43.88  ? 377  THR A N   1 
ATOM   714  C  CA  . THR A 1 114 ? -6.522  -20.317 -35.171 1.00 38.67  ? 377  THR A CA  1 
ATOM   715  C  C   . THR A 1 114 ? -7.965  -20.452 -34.677 1.00 34.94  ? 377  THR A C   1 
ATOM   716  O  O   . THR A 1 114 ? -8.765  -21.172 -35.347 1.00 28.16  ? 377  THR A O   1 
ATOM   717  C  CB  . THR A 1 114 ? -5.513  -21.207 -34.445 1.00 36.81  ? 377  THR A CB  1 
ATOM   718  O  OG1 . THR A 1 114 ? -4.233  -20.912 -35.004 1.00 37.08  ? 377  THR A OG1 1 
ATOM   719  C  CG2 . THR A 1 114 ? -5.800  -22.676 -34.628 1.00 36.04  ? 377  THR A CG2 1 
ATOM   720  N  N   . ALA A 1 115 ? -8.289  -19.764 -33.575 1.00 36.54  ? 378  ALA A N   1 
ATOM   721  C  CA  . ALA A 1 115 ? -9.634  -19.753 -32.959 1.00 37.17  ? 378  ALA A CA  1 
ATOM   722  C  C   . ALA A 1 115 ? -10.667 -19.169 -33.943 1.00 39.49  ? 378  ALA A C   1 
ATOM   723  O  O   . ALA A 1 115 ? -11.697 -19.829 -34.213 1.00 42.59  ? 378  ALA A O   1 
ATOM   724  C  CB  . ALA A 1 115 ? -9.585  -19.007 -31.653 1.00 38.23  ? 378  ALA A CB  1 
ATOM   725  N  N   . GLU A 1 116 ? -10.375 -18.008 -34.529 1.00 42.71  ? 379  GLU A N   1 
ATOM   726  C  CA  . GLU A 1 116 ? -11.239 -17.361 -35.547 1.00 40.70  ? 379  GLU A CA  1 
ATOM   727  C  C   . GLU A 1 116 ? -11.528 -18.368 -36.678 1.00 39.93  ? 379  GLU A C   1 
ATOM   728  O  O   . GLU A 1 116 ? -12.701 -18.588 -37.013 1.00 41.21  ? 379  GLU A O   1 
ATOM   729  C  CB  . GLU A 1 116 ? -10.570 -16.070 -36.017 1.00 44.95  ? 379  GLU A CB  1 
ATOM   730  C  CG  . GLU A 1 116 ? -11.444 -15.254 -36.957 1.00 55.58  ? 379  GLU A CG  1 
ATOM   731  C  CD  . GLU A 1 116 ? -10.807 -14.082 -37.689 1.00 61.05  ? 379  GLU A CD  1 
ATOM   732  O  OE1 . GLU A 1 116 ? -9.546  -14.031 -37.781 1.00 64.03  ? 379  GLU A OE1 1 
ATOM   733  O  OE2 . GLU A 1 116 ? -11.586 -13.234 -38.186 1.00 68.43  ? 379  GLU A OE2 1 
ATOM   734  N  N   . TRP A 1 117 ? -10.503 -18.966 -37.268 1.00 35.72  ? 380  TRP A N   1 
ATOM   735  C  CA  . TRP A 1 117 ? -10.663 -19.929 -38.384 1.00 35.99  ? 380  TRP A CA  1 
ATOM   736  C  C   . TRP A 1 117 ? -11.445 -21.162 -37.893 1.00 44.52  ? 380  TRP A C   1 
ATOM   737  O  O   . TRP A 1 117 ? -12.226 -21.745 -38.702 1.00 45.32  ? 380  TRP A O   1 
ATOM   738  C  CB  . TRP A 1 117 ? -9.273  -20.303 -38.910 1.00 34.93  ? 380  TRP A CB  1 
ATOM   739  C  CG  . TRP A 1 117 ? -9.323  -21.379 -39.926 1.00 33.76  ? 380  TRP A CG  1 
ATOM   740  C  CD1 . TRP A 1 117 ? -9.482  -21.226 -41.265 1.00 38.54  ? 380  TRP A CD1 1 
ATOM   741  C  CD2 . TRP A 1 117 ? -9.282  -22.790 -39.684 1.00 37.81  ? 380  TRP A CD2 1 
ATOM   742  N  NE1 . TRP A 1 117 ? -9.470  -22.445 -41.885 1.00 43.47  ? 380  TRP A NE1 1 
ATOM   743  C  CE2 . TRP A 1 117 ? -9.385  -23.427 -40.939 1.00 36.80  ? 380  TRP A CE2 1 
ATOM   744  C  CE3 . TRP A 1 117 ? -9.161  -23.574 -38.536 1.00 37.11  ? 380  TRP A CE3 1 
ATOM   745  C  CZ2 . TRP A 1 117 ? -9.389  -24.810 -41.078 1.00 36.96  ? 380  TRP A CZ2 1 
ATOM   746  C  CZ3 . TRP A 1 117 ? -9.130  -24.941 -38.675 1.00 32.61  ? 380  TRP A CZ3 1 
ATOM   747  C  CH2 . TRP A 1 117 ? -9.237  -25.546 -39.924 1.00 36.98  ? 380  TRP A CH2 1 
ATOM   748  N  N   . LEU A 1 118 ? -11.242 -21.595 -36.636 1.00 40.90  ? 381  LEU A N   1 
ATOM   749  C  CA  . LEU A 1 118 ? -11.832 -22.879 -36.156 1.00 38.25  ? 381  LEU A CA  1 
ATOM   750  C  C   . LEU A 1 118 ? -13.351 -22.707 -35.957 1.00 34.46  ? 381  LEU A C   1 
ATOM   751  O  O   . LEU A 1 118 ? -14.136 -23.545 -36.493 1.00 30.34  ? 381  LEU A O   1 
ATOM   752  C  CB  . LEU A 1 118 ? -11.137 -23.343 -34.871 1.00 39.19  ? 381  LEU A CB  1 
ATOM   753  C  CG  . LEU A 1 118 ? -11.524 -24.753 -34.423 1.00 42.03  ? 381  LEU A CG  1 
ATOM   754  C  CD1 . LEU A 1 118 ? -11.341 -25.771 -35.551 1.00 38.16  ? 381  LEU A CD1 1 
ATOM   755  C  CD2 . LEU A 1 118 ? -10.762 -25.173 -33.171 1.00 42.99  ? 381  LEU A CD2 1 
ATOM   756  N  N   . TRP A 1 119 ? -13.764 -21.661 -35.241 1.00 31.85  ? 382  TRP A N   1 
ATOM   757  C  CA  . TRP A 1 119 ? -15.202 -21.314 -35.085 1.00 33.85  ? 382  TRP A CA  1 
ATOM   758  C  C   . TRP A 1 119 ? -15.895 -21.178 -36.459 1.00 38.98  ? 382  TRP A C   1 
ATOM   759  O  O   . TRP A 1 119 ? -17.013 -21.769 -36.634 1.00 45.13  ? 382  TRP A O   1 
ATOM   760  C  CB  . TRP A 1 119 ? -15.351 -20.063 -34.239 1.00 33.50  ? 382  TRP A CB  1 
ATOM   761  C  CG  . TRP A 1 119 ? -15.173 -20.252 -32.767 1.00 31.09  ? 382  TRP A CG  1 
ATOM   762  C  CD1 . TRP A 1 119 ? -14.422 -19.469 -31.952 1.00 31.79  ? 382  TRP A CD1 1 
ATOM   763  C  CD2 . TRP A 1 119 ? -15.836 -21.195 -31.903 1.00 31.72  ? 382  TRP A CD2 1 
ATOM   764  N  NE1 . TRP A 1 119 ? -14.574 -19.846 -30.641 1.00 33.21  ? 382  TRP A NE1 1 
ATOM   765  C  CE2 . TRP A 1 119 ? -15.448 -20.892 -30.580 1.00 32.02  ? 382  TRP A CE2 1 
ATOM   766  C  CE3 . TRP A 1 119 ? -16.765 -22.224 -32.099 1.00 32.27  ? 382  TRP A CE3 1 
ATOM   767  C  CZ2 . TRP A 1 119 ? -15.873 -21.643 -29.482 1.00 35.94  ? 382  TRP A CZ2 1 
ATOM   768  C  CZ3 . TRP A 1 119 ? -17.199 -22.957 -31.014 1.00 31.81  ? 382  TRP A CZ3 1 
ATOM   769  C  CH2 . TRP A 1 119 ? -16.761 -22.672 -29.724 1.00 31.77  ? 382  TRP A CH2 1 
ATOM   770  N  N   . LYS A 1 120 ? -15.283 -20.516 -37.443 1.00 35.95  ? 383  LYS A N   1 
ATOM   771  C  CA  . LYS A 1 120 ? -15.885 -20.425 -38.801 1.00 40.94  ? 383  LYS A CA  1 
ATOM   772  C  C   . LYS A 1 120 ? -16.098 -21.845 -39.326 1.00 42.67  ? 383  LYS A C   1 
ATOM   773  O  O   . LYS A 1 120 ? -17.189 -22.114 -39.853 1.00 48.96  ? 383  LYS A O   1 
ATOM   774  C  CB  . LYS A 1 120 ? -15.028 -19.692 -39.846 1.00 51.06  ? 383  LYS A CB  1 
ATOM   775  C  CG  . LYS A 1 120 ? -15.051 -18.172 -39.824 1.00 60.20  ? 383  LYS A CG  1 
ATOM   776  C  CD  . LYS A 1 120 ? -14.501 -17.562 -41.113 1.00 72.43  ? 383  LYS A CD  1 
ATOM   777  C  CE  . LYS A 1 120 ? -14.419 -16.049 -41.082 1.00 77.12  ? 383  LYS A CE  1 
ATOM   778  N  NZ  . LYS A 1 120 ? -13.659 -15.570 -39.901 1.00 79.07  ? 383  LYS A NZ  1 
ATOM   779  N  N   . GLU A 1 121 ? -15.088 -22.714 -39.256 1.00 39.91  ? 384  GLU A N   1 
ATOM   780  C  CA  . GLU A 1 121 ? -15.221 -24.087 -39.811 1.00 39.52  ? 384  GLU A CA  1 
ATOM   781  C  C   . GLU A 1 121 ? -16.345 -24.840 -39.107 1.00 38.47  ? 384  GLU A C   1 
ATOM   782  O  O   . GLU A 1 121 ? -17.074 -25.584 -39.806 1.00 37.31  ? 384  GLU A O   1 
ATOM   783  C  CB  . GLU A 1 121 ? -13.962 -24.918 -39.613 1.00 41.91  ? 384  GLU A CB  1 
ATOM   784  C  CG  . GLU A 1 121 ? -12.851 -24.487 -40.507 1.00 45.24  ? 384  GLU A CG  1 
ATOM   785  C  CD  . GLU A 1 121 ? -13.122 -24.653 -41.984 1.00 48.57  ? 384  GLU A CD  1 
ATOM   786  O  OE1 . GLU A 1 121 ? -13.604 -25.734 -42.412 1.00 46.95  ? 384  GLU A OE1 1 
ATOM   787  O  OE2 . GLU A 1 121 ? -12.799 -23.707 -42.694 1.00 50.86  ? 384  GLU A OE2 1 
ATOM   788  N  N   . LEU A 1 122 ? -16.414 -24.742 -37.774 1.00 34.79  ? 385  LEU A N   1 
ATOM   789  C  CA  . LEU A 1 122 ? -17.411 -25.513 -36.983 1.00 36.83  ? 385  LEU A CA  1 
ATOM   790  C  C   . LEU A 1 122 ? -18.798 -24.961 -37.337 1.00 36.83  ? 385  LEU A C   1 
ATOM   791  O  O   . LEU A 1 122 ? -19.784 -25.702 -37.231 1.00 36.55  ? 385  LEU A O   1 
ATOM   792  C  CB  . LEU A 1 122 ? -17.107 -25.380 -35.477 1.00 36.76  ? 385  LEU A CB  1 
ATOM   793  C  CG  . LEU A 1 122 ? -15.877 -26.146 -34.984 1.00 35.05  ? 385  LEU A CG  1 
ATOM   794  C  CD1 . LEU A 1 122 ? -15.617 -25.926 -33.511 1.00 33.34  ? 385  LEU A CD1 1 
ATOM   795  C  CD2 . LEU A 1 122 ? -16.046 -27.618 -35.245 1.00 36.34  ? 385  LEU A CD2 1 
ATOM   796  N  N   . GLY A 1 123 ? -18.851 -23.689 -37.729 1.00 39.06  ? 386  GLY A N   1 
ATOM   797  C  CA  . GLY A 1 123 ? -20.098 -22.953 -37.989 1.00 42.57  ? 386  GLY A CA  1 
ATOM   798  C  C   . GLY A 1 123 ? -20.601 -23.133 -39.407 1.00 43.30  ? 386  GLY A C   1 
ATOM   799  O  O   . GLY A 1 123 ? -21.745 -22.736 -39.646 1.00 50.69  ? 386  GLY A O   1 
ATOM   800  N  N   . LYS A 1 124 ? -19.817 -23.705 -40.320 1.00 41.24  ? 387  LYS A N   1 
ATOM   801  C  CA  . LYS A 1 124 ? -20.200 -23.743 -41.759 1.00 43.76  ? 387  LYS A CA  1 
ATOM   802  C  C   . LYS A 1 124 ? -21.532 -24.475 -41.948 1.00 44.76  ? 387  LYS A C   1 
ATOM   803  O  O   . LYS A 1 124 ? -22.296 -24.041 -42.806 1.00 50.32  ? 387  LYS A O   1 
ATOM   804  C  CB  . LYS A 1 124 ? -19.130 -24.385 -42.643 1.00 45.11  ? 387  LYS A CB  1 
ATOM   805  C  CG  . LYS A 1 124 ? -17.902 -23.509 -42.886 1.00 53.26  ? 387  LYS A CG  1 
ATOM   806  C  CD  . LYS A 1 124 ? -17.070 -23.989 -44.050 1.00 57.64  ? 387  LYS A CD  1 
ATOM   807  C  CE  . LYS A 1 124 ? -15.700 -23.357 -44.128 1.00 62.16  ? 387  LYS A CE  1 
ATOM   808  N  NZ  . LYS A 1 124 ? -14.802 -24.213 -44.944 1.00 66.82  ? 387  LYS A NZ  1 
ATOM   809  N  N   . LYS A 1 125 ? -21.788 -25.537 -41.184 1.00 44.48  ? 388  LYS A N   1 
ATOM   810  C  CA  . LYS A 1 125 ? -22.948 -26.442 -41.365 1.00 41.87  ? 388  LYS A CA  1 
ATOM   811  C  C   . LYS A 1 125 ? -23.789 -26.508 -40.086 1.00 40.03  ? 388  LYS A C   1 
ATOM   812  O  O   . LYS A 1 125 ? -24.597 -27.426 -39.965 1.00 43.59  ? 388  LYS A O   1 
ATOM   813  C  CB  . LYS A 1 125 ? -22.429 -27.825 -41.735 1.00 46.66  ? 388  LYS A CB  1 
ATOM   814  C  CG  . LYS A 1 125 ? -21.819 -27.917 -43.119 1.00 55.07  ? 388  LYS A CG  1 
ATOM   815  C  CD  . LYS A 1 125 ? -21.224 -29.291 -43.368 1.00 64.64  ? 388  LYS A CD  1 
ATOM   816  C  CE  . LYS A 1 125 ? -19.938 -29.535 -42.596 1.00 74.47  ? 388  LYS A CE  1 
ATOM   817  N  NZ  . LYS A 1 125 ? -19.984 -30.820 -41.853 1.00 81.96  ? 388  LYS A NZ  1 
ATOM   818  N  N   . LYS A 1 126 ? -23.599 -25.573 -39.157 1.00 42.29  ? 389  LYS A N   1 
ATOM   819  C  CA  . LYS A 1 126 ? -24.386 -25.482 -37.908 1.00 40.85  ? 389  LYS A CA  1 
ATOM   820  C  C   . LYS A 1 126 ? -24.851 -24.048 -37.744 1.00 40.07  ? 389  LYS A C   1 
ATOM   821  O  O   . LYS A 1 126 ? -24.139 -23.173 -38.187 1.00 41.36  ? 389  LYS A O   1 
ATOM   822  C  CB  . LYS A 1 126 ? -23.568 -25.807 -36.662 1.00 43.80  ? 389  LYS A CB  1 
ATOM   823  C  CG  . LYS A 1 126 ? -22.980 -27.197 -36.643 1.00 41.12  ? 389  LYS A CG  1 
ATOM   824  C  CD  . LYS A 1 126 ? -24.013 -28.226 -36.466 1.00 43.96  ? 389  LYS A CD  1 
ATOM   825  C  CE  . LYS A 1 126 ? -23.392 -29.547 -36.086 1.00 41.37  ? 389  LYS A CE  1 
ATOM   826  N  NZ  . LYS A 1 126 ? -24.242 -30.669 -36.515 1.00 35.01  ? 389  LYS A NZ  1 
ATOM   827  N  N   . THR A 1 127 ? -26.016 -23.861 -37.111 1.00 40.95  ? 390  THR A N   1 
ATOM   828  C  CA  . THR A 1 127 ? -26.568 -22.549 -36.714 1.00 40.54  ? 390  THR A CA  1 
ATOM   829  C  C   . THR A 1 127 ? -26.600 -22.467 -35.202 1.00 33.87  ? 390  THR A C   1 
ATOM   830  O  O   . THR A 1 127 ? -27.361 -23.179 -34.576 1.00 36.05  ? 390  THR A O   1 
ATOM   831  C  CB  . THR A 1 127 ? -28.013 -22.382 -37.204 1.00 45.77  ? 390  THR A CB  1 
ATOM   832  O  OG1 . THR A 1 127 ? -28.002 -22.590 -38.612 1.00 45.81  ? 390  THR A OG1 1 
ATOM   833  C  CG2 . THR A 1 127 ? -28.584 -21.028 -36.862 1.00 45.17  ? 390  THR A CG2 1 
ATOM   834  N  N   . PRO A 1 128 ? -25.884 -21.530 -34.559 1.00 32.96  ? 391  PRO A N   1 
ATOM   835  C  CA  . PRO A 1 128 ? -26.100 -21.316 -33.125 1.00 35.40  ? 391  PRO A CA  1 
ATOM   836  C  C   . PRO A 1 128 ? -27.602 -21.101 -32.858 1.00 38.71  ? 391  PRO A C   1 
ATOM   837  O  O   . PRO A 1 128 ? -28.325 -20.674 -33.755 1.00 42.72  ? 391  PRO A O   1 
ATOM   838  C  CB  . PRO A 1 128 ? -25.260 -20.071 -32.803 1.00 33.89  ? 391  PRO A CB  1 
ATOM   839  C  CG  . PRO A 1 128 ? -24.266 -19.979 -33.948 1.00 33.17  ? 391  PRO A CG  1 
ATOM   840  C  CD  . PRO A 1 128 ? -24.915 -20.615 -35.159 1.00 29.84  ? 391  PRO A CD  1 
ATOM   841  N  N   . ARG A 1 129 ? -28.067 -21.400 -31.653 1.00 38.81  ? 392  ARG A N   1 
ATOM   842  C  CA  . ARG A 1 129 ? -29.481 -21.154 -31.266 1.00 38.57  ? 392  ARG A CA  1 
ATOM   843  C  C   . ARG A 1 129 ? -29.624 -21.357 -29.766 1.00 43.93  ? 392  ARG A C   1 
ATOM   844  O  O   . ARG A 1 129 ? -28.748 -22.045 -29.185 1.00 37.92  ? 392  ARG A O   1 
ATOM   845  C  CB  . ARG A 1 129 ? -30.449 -22.023 -32.074 1.00 42.57  ? 392  ARG A CB  1 
ATOM   846  C  CG  . ARG A 1 129 ? -30.150 -23.514 -32.098 1.00 42.28  ? 392  ARG A CG  1 
ATOM   847  C  CD  . ARG A 1 129 ? -30.978 -24.147 -31.018 1.00 43.06  ? 392  ARG A CD  1 
ATOM   848  N  NE  . ARG A 1 129 ? -30.786 -25.575 -30.871 1.00 42.69  ? 392  ARG A NE  1 
ATOM   849  C  CZ  . ARG A 1 129 ? -31.288 -26.284 -29.874 1.00 39.68  ? 392  ARG A CZ  1 
ATOM   850  N  NH1 . ARG A 1 129 ? -32.051 -25.711 -28.961 1.00 43.57  ? 392  ARG A NH1 1 
ATOM   851  N  NH2 . ARG A 1 129 ? -31.061 -27.571 -29.814 1.00 39.84  ? 392  ARG A NH2 1 
ATOM   852  N  N   . MET A 1 130 ? -30.642 -20.724 -29.164 1.00 42.56  ? 393  MET A N   1 
ATOM   853  C  CA  . MET A 1 130 ? -30.926 -20.833 -27.718 1.00 42.55  ? 393  MET A CA  1 
ATOM   854  C  C   . MET A 1 130 ? -31.551 -22.195 -27.430 1.00 41.40  ? 393  MET A C   1 
ATOM   855  O  O   . MET A 1 130 ? -32.318 -22.669 -28.267 1.00 42.45  ? 393  MET A O   1 
ATOM   856  C  CB  . MET A 1 130 ? -31.873 -19.731 -27.263 1.00 53.40  ? 393  MET A CB  1 
ATOM   857  C  CG  . MET A 1 130 ? -31.176 -18.406 -27.102 1.00 63.68  ? 393  MET A CG  1 
ATOM   858  S  SD  . MET A 1 130 ? -32.274 -17.165 -26.404 1.00 74.17  ? 393  MET A SD  1 
ATOM   859  C  CE  . MET A 1 130 ? -32.751 -16.297 -27.898 1.00 76.90  ? 393  MET A CE  1 
ATOM   860  N  N   . CYS A 1 131 ? -31.185 -22.820 -26.311 1.00 38.81  ? 394  CYS A N   1 
ATOM   861  C  CA  . CYS A 1 131 ? -31.877 -24.021 -25.772 1.00 43.04  ? 394  CYS A CA  1 
ATOM   862  C  C   . CYS A 1 131 ? -33.007 -23.544 -24.835 1.00 47.59  ? 394  CYS A C   1 
ATOM   863  O  O   . CYS A 1 131 ? -32.911 -22.402 -24.282 1.00 51.91  ? 394  CYS A O   1 
ATOM   864  C  CB  . CYS A 1 131 ? -30.874 -24.951 -25.090 1.00 44.45  ? 394  CYS A CB  1 
ATOM   865  S  SG  . CYS A 1 131 ? -29.757 -25.783 -26.253 1.00 45.07  ? 394  CYS A SG  1 
ATOM   866  N  N   . THR A 1 132 ? -34.055 -24.349 -24.668 1.00 48.24  ? 395  THR A N   1 
ATOM   867  C  CA  . THR A 1 132 ? -35.371 -23.898 -24.120 1.00 51.00  ? 395  THR A CA  1 
ATOM   868  C  C   . THR A 1 132 ? -35.629 -24.502 -22.735 1.00 52.53  ? 395  THR A C   1 
ATOM   869  O  O   . THR A 1 132 ? -35.111 -25.624 -22.483 1.00 48.64  ? 395  THR A O   1 
ATOM   870  C  CB  . THR A 1 132 ? -36.502 -24.321 -25.062 1.00 52.81  ? 395  THR A CB  1 
ATOM   871  O  OG1 . THR A 1 132 ? -36.509 -25.752 -25.086 1.00 50.74  ? 395  THR A OG1 1 
ATOM   872  C  CG2 . THR A 1 132 ? -36.348 -23.766 -26.464 1.00 52.29  ? 395  THR A CG2 1 
ATOM   873  N  N   . ARG A 1 133 ? -36.427 -23.810 -21.905 1.00 57.17  ? 396  ARG A N   1 
ATOM   874  C  CA  . ARG A 1 133 ? -37.007 -24.331 -20.629 1.00 61.51  ? 396  ARG A CA  1 
ATOM   875  C  C   . ARG A 1 133 ? -37.516 -25.755 -20.868 1.00 61.40  ? 396  ARG A C   1 
ATOM   876  O  O   . ARG A 1 133 ? -37.158 -26.666 -20.108 1.00 64.41  ? 396  ARG A O   1 
ATOM   877  C  CB  . ARG A 1 133 ? -38.164 -23.462 -20.116 1.00 71.73  ? 396  ARG A CB  1 
ATOM   878  C  CG  . ARG A 1 133 ? -37.866 -21.968 -20.144 1.00 86.75  ? 396  ARG A CG  1 
ATOM   879  C  CD  . ARG A 1 133 ? -38.618 -21.053 -19.184 1.00 91.35  ? 396  ARG A CD  1 
ATOM   880  N  NE  . ARG A 1 133 ? -37.818 -19.855 -18.917 1.00 89.97  ? 396  ARG A NE  1 
ATOM   881  C  CZ  . ARG A 1 133 ? -38.217 -18.780 -18.235 1.00 97.46  ? 396  ARG A CZ  1 
ATOM   882  N  NH1 . ARG A 1 133 ? -39.446 -18.702 -17.746 1.00 96.10  ? 396  ARG A NH1 1 
ATOM   883  N  NH2 . ARG A 1 133 ? -37.378 -17.770 -18.067 1.00 93.47  ? 396  ARG A NH2 1 
ATOM   884  N  N   . GLU A 1 134 ? -38.282 -25.936 -21.938 1.00 61.32  ? 397  GLU A N   1 
ATOM   885  C  CA  . GLU A 1 134 ? -38.863 -27.236 -22.329 1.00 60.66  ? 397  GLU A CA  1 
ATOM   886  C  C   . GLU A 1 134 ? -37.722 -28.247 -22.360 1.00 58.70  ? 397  GLU A C   1 
ATOM   887  O  O   . GLU A 1 134 ? -37.789 -29.178 -21.575 1.00 68.49  ? 397  GLU A O   1 
ATOM   888  C  CB  . GLU A 1 134 ? -39.606 -27.103 -23.659 1.00 69.08  ? 397  GLU A CB  1 
ATOM   889  C  CG  . GLU A 1 134 ? -40.901 -26.304 -23.566 1.00 76.89  ? 397  GLU A CG  1 
ATOM   890  C  CD  . GLU A 1 134 ? -40.827 -24.802 -23.275 1.00 86.29  ? 397  GLU A CD  1 
ATOM   891  O  OE1 . GLU A 1 134 ? -39.963 -24.089 -23.865 1.00 79.76  ? 397  GLU A OE1 1 
ATOM   892  O  OE2 . GLU A 1 134 ? -41.663 -24.329 -22.467 1.00 92.14  ? 397  GLU A OE2 1 
ATOM   893  N  N   . GLU A 1 135 ? -36.687 -28.035 -23.189 1.00 62.52  ? 398  GLU A N   1 
ATOM   894  C  CA  . GLU A 1 135 ? -35.539 -28.981 -23.335 1.00 62.83  ? 398  GLU A CA  1 
ATOM   895  C  C   . GLU A 1 135 ? -34.912 -29.274 -21.963 1.00 62.23  ? 398  GLU A C   1 
ATOM   896  O  O   . GLU A 1 135 ? -34.638 -30.447 -21.666 1.00 58.69  ? 398  GLU A O   1 
ATOM   897  C  CB  . GLU A 1 135 ? -34.453 -28.445 -24.271 1.00 60.88  ? 398  GLU A CB  1 
ATOM   898  C  CG  . GLU A 1 135 ? -34.818 -28.505 -25.739 1.00 60.02  ? 398  GLU A CG  1 
ATOM   899  C  CD  . GLU A 1 135 ? -33.785 -27.906 -26.680 1.00 60.13  ? 398  GLU A CD  1 
ATOM   900  O  OE1 . GLU A 1 135 ? -33.343 -26.767 -26.429 1.00 49.83  ? 398  GLU A OE1 1 
ATOM   901  O  OE2 . GLU A 1 135 ? -33.425 -28.586 -27.665 1.00 61.44  ? 398  GLU A OE2 1 
ATOM   902  N  N   . PHE A 1 136 ? -34.703 -28.228 -21.155 0.26 62.46  ? 399  PHE A N   1 
ATOM   903  C  CA  . PHE A 1 136 ? -34.111 -28.296 -19.792 0.26 62.76  ? 399  PHE A CA  1 
ATOM   904  C  C   . PHE A 1 136 ? -35.052 -29.066 -18.856 0.26 64.33  ? 399  PHE A C   1 
ATOM   905  O  O   . PHE A 1 136 ? -34.576 -29.972 -18.140 0.26 62.18  ? 399  PHE A O   1 
ATOM   906  C  CB  . PHE A 1 136 ? -33.832 -26.888 -19.257 0.26 62.98  ? 399  PHE A CB  1 
ATOM   907  C  CG  . PHE A 1 136 ? -33.099 -26.846 -17.940 0.26 62.86  ? 399  PHE A CG  1 
ATOM   908  C  CD1 . PHE A 1 136 ? -31.715 -26.764 -17.901 0.26 61.86  ? 399  PHE A CD1 1 
ATOM   909  C  CD2 . PHE A 1 136 ? -33.792 -26.882 -16.739 0.26 62.35  ? 399  PHE A CD2 1 
ATOM   910  C  CE1 . PHE A 1 136 ? -31.041 -26.721 -16.690 0.26 61.88  ? 399  PHE A CE1 1 
ATOM   911  C  CE2 . PHE A 1 136 ? -33.116 -26.841 -15.529 0.26 62.97  ? 399  PHE A CE2 1 
ATOM   912  C  CZ  . PHE A 1 136 ? -31.741 -26.760 -15.507 0.26 62.61  ? 399  PHE A CZ  1 
ATOM   913  N  N   . THR A 1 137 ? -36.341 -28.702 -18.866 0.26 65.60  ? 400  THR A N   1 
ATOM   914  C  CA  . THR A 1 137 ? -37.429 -29.312 -18.051 0.26 65.97  ? 400  THR A CA  1 
ATOM   915  C  C   . THR A 1 137 ? -37.491 -30.822 -18.315 0.26 65.89  ? 400  THR A C   1 
ATOM   916  O  O   . THR A 1 137 ? -37.702 -31.575 -17.348 0.26 67.67  ? 400  THR A O   1 
ATOM   917  C  CB  . THR A 1 137 ? -38.776 -28.625 -18.328 0.26 65.76  ? 400  THR A CB  1 
ATOM   918  O  OG1 . THR A 1 137 ? -38.696 -27.288 -17.833 0.26 65.42  ? 400  THR A OG1 1 
ATOM   919  C  CG2 . THR A 1 137 ? -39.958 -29.329 -17.698 0.26 65.44  ? 400  THR A CG2 1 
ATOM   920  N  N   . ARG A 1 138 ? -37.321 -31.242 -19.572 0.26 66.25  ? 401  ARG A N   1 
ATOM   921  C  CA  . ARG A 1 138 ? -37.351 -32.673 -19.980 0.26 67.29  ? 401  ARG A CA  1 
ATOM   922  C  C   . ARG A 1 138 ? -36.154 -33.402 -19.357 0.26 66.34  ? 401  ARG A C   1 
ATOM   923  O  O   . ARG A 1 138 ? -36.371 -34.452 -18.725 0.26 68.21  ? 401  ARG A O   1 
ATOM   924  C  CB  . ARG A 1 138 ? -37.365 -32.791 -21.509 0.26 69.47  ? 401  ARG A CB  1 
ATOM   925  C  CG  . ARG A 1 138 ? -37.212 -34.215 -22.030 0.26 71.98  ? 401  ARG A CG  1 
ATOM   926  C  CD  . ARG A 1 138 ? -37.984 -34.459 -23.315 0.26 72.87  ? 401  ARG A CD  1 
ATOM   927  N  NE  . ARG A 1 138 ? -37.471 -33.678 -24.437 0.26 74.04  ? 401  ARG A NE  1 
ATOM   928  C  CZ  . ARG A 1 138 ? -36.909 -34.172 -25.542 0.26 74.60  ? 401  ARG A CZ  1 
ATOM   929  N  NH1 . ARG A 1 138 ? -36.775 -35.478 -25.720 0.26 73.70  ? 401  ARG A NH1 1 
ATOM   930  N  NH2 . ARG A 1 138 ? -36.486 -33.343 -26.482 0.26 74.38  ? 401  ARG A NH2 1 
ATOM   931  N  N   . LYS A 1 139 ? -34.940 -32.897 -19.566 0.26 65.87  ? 402  LYS A N   1 
ATOM   932  C  CA  . LYS A 1 139 ? -33.730 -33.612 -19.081 0.26 65.59  ? 402  LYS A CA  1 
ATOM   933  C  C   . LYS A 1 139 ? -33.830 -33.895 -17.577 0.26 66.93  ? 402  LYS A C   1 
ATOM   934  O  O   . LYS A 1 139 ? -33.628 -35.059 -17.189 0.26 67.17  ? 402  LYS A O   1 
ATOM   935  C  CB  . LYS A 1 139 ? -32.479 -32.784 -19.380 0.26 65.49  ? 402  LYS A CB  1 
ATOM   936  C  CG  . LYS A 1 139 ? -32.168 -32.592 -20.857 0.26 66.79  ? 402  LYS A CG  1 
ATOM   937  C  CD  . LYS A 1 139 ? -30.757 -32.108 -21.091 0.26 68.07  ? 402  LYS A CD  1 
ATOM   938  C  CE  . LYS A 1 139 ? -30.342 -32.167 -22.545 0.26 67.68  ? 402  LYS A CE  1 
ATOM   939  N  NZ  . LYS A 1 139 ? -28.867 -32.183 -22.676 0.26 67.59  ? 402  LYS A NZ  1 
ATOM   940  N  N   . VAL A 1 140 ? -34.112 -32.875 -16.767 0.26 67.49  ? 403  VAL A N   1 
ATOM   941  C  CA  . VAL A 1 140 ? -34.137 -33.040 -15.281 0.26 69.11  ? 403  VAL A CA  1 
ATOM   942  C  C   . VAL A 1 140 ? -35.132 -34.151 -14.918 0.26 69.14  ? 403  VAL A C   1 
ATOM   943  O  O   . VAL A 1 140 ? -34.880 -34.863 -13.922 0.26 67.87  ? 403  VAL A O   1 
ATOM   944  C  CB  . VAL A 1 140 ? -34.459 -31.721 -14.547 0.26 70.03  ? 403  VAL A CB  1 
ATOM   945  C  CG1 . VAL A 1 140 ? -33.404 -30.657 -14.810 0.26 70.29  ? 403  VAL A CG1 1 
ATOM   946  C  CG2 . VAL A 1 140 ? -35.846 -31.190 -14.876 0.26 70.97  ? 403  VAL A CG2 1 
ATOM   947  N  N   . ARG A 1 141 ? -36.208 -34.299 -15.702 0.26 68.40  ? 404  ARG A N   1 
ATOM   948  C  CA  . ARG A 1 141 ? -37.266 -35.325 -15.491 0.26 67.16  ? 404  ARG A CA  1 
ATOM   949  C  C   . ARG A 1 141 ? -36.781 -36.691 -15.992 0.26 65.66  ? 404  ARG A C   1 
ATOM   950  O  O   . ARG A 1 141 ? -37.414 -37.699 -15.625 0.26 67.01  ? 404  ARG A O   1 
ATOM   951  C  CB  . ARG A 1 141 ? -38.578 -34.907 -16.162 0.26 67.31  ? 404  ARG A CB  1 
ATOM   952  C  CG  . ARG A 1 141 ? -39.402 -33.927 -15.338 0.26 68.79  ? 404  ARG A CG  1 
ATOM   953  C  CD  . ARG A 1 141 ? -40.895 -34.203 -15.392 0.26 70.73  ? 404  ARG A CD  1 
ATOM   954  N  NE  . ARG A 1 141 ? -41.556 -33.578 -16.532 0.26 71.30  ? 404  ARG A NE  1 
ATOM   955  C  CZ  . ARG A 1 141 ? -41.908 -32.296 -16.607 0.26 71.33  ? 404  ARG A CZ  1 
ATOM   956  N  NH1 . ARG A 1 141 ? -41.655 -31.466 -15.606 0.26 71.30  ? 404  ARG A NH1 1 
ATOM   957  N  NH2 . ARG A 1 141 ? -42.511 -31.843 -17.694 0.26 71.02  ? 404  ARG A NH2 1 
ATOM   958  N  N   . SER A 1 142 ? -35.709 -36.723 -16.792 0.26 65.07  ? 405  SER A N   1 
ATOM   959  C  CA  . SER A 1 142 ? -34.985 -37.955 -17.208 0.26 65.34  ? 405  SER A CA  1 
ATOM   960  C  C   . SER A 1 142 ? -33.589 -37.984 -16.565 0.26 63.65  ? 405  SER A C   1 
ATOM   961  O  O   . SER A 1 142 ? -32.669 -38.573 -17.169 0.26 62.36  ? 405  SER A O   1 
ATOM   962  C  CB  . SER A 1 142 ? -34.917 -38.055 -18.714 0.26 65.98  ? 405  SER A CB  1 
ATOM   963  O  OG  . SER A 1 142 ? -34.311 -36.899 -19.272 0.26 67.37  ? 405  SER A OG  1 
ATOM   964  N  N   . ASN A 1 143 ? -33.452 -37.373 -15.380 0.26 62.72  ? 406  ASN A N   1 
ATOM   965  C  CA  . ASN A 1 143 ? -32.206 -37.315 -14.565 0.26 61.81  ? 406  ASN A CA  1 
ATOM   966  C  C   . ASN A 1 143 ? -31.142 -36.510 -15.325 0.26 61.11  ? 406  ASN A C   1 
ATOM   967  O  O   . ASN A 1 143 ? -30.268 -37.146 -15.952 0.26 60.22  ? 406  ASN A O   1 
ATOM   968  C  CB  . ASN A 1 143 ? -31.730 -38.718 -14.169 0.26 61.18  ? 406  ASN A CB  1 
ATOM   969  C  CG  . ASN A 1 143 ? -30.665 -38.712 -13.091 0.26 59.27  ? 406  ASN A CG  1 
ATOM   970  O  OD1 . ASN A 1 143 ? -30.225 -37.654 -12.643 0.26 57.54  ? 406  ASN A OD1 1 
ATOM   971  N  ND2 . ASN A 1 143 ? -30.238 -39.892 -12.672 0.26 59.01  ? 406  ASN A ND2 1 
ATOM   972  N  N   . LYS A 1 155 ? -36.038 -24.205 -0.753  0.26 62.13  ? 418  LYS A N   1 
ATOM   973  C  CA  . LYS A 1 155 ? -37.272 -23.872 -1.517  0.26 60.87  ? 418  LYS A CA  1 
ATOM   974  C  C   . LYS A 1 155 ? -37.781 -25.131 -2.236  0.26 60.23  ? 418  LYS A C   1 
ATOM   975  O  O   . LYS A 1 155 ? -39.011 -25.328 -2.268  0.26 59.13  ? 418  LYS A O   1 
ATOM   976  C  CB  . LYS A 1 155 ? -37.003 -22.727 -2.502  0.26 60.53  ? 418  LYS A CB  1 
ATOM   977  C  CG  . LYS A 1 155 ? -38.054 -21.622 -2.541  0.26 60.11  ? 418  LYS A CG  1 
ATOM   978  C  CD  . LYS A 1 155 ? -39.480 -22.108 -2.726  0.26 59.11  ? 418  LYS A CD  1 
ATOM   979  C  CE  . LYS A 1 155 ? -40.505 -21.003 -2.585  0.26 58.77  ? 418  LYS A CE  1 
ATOM   980  N  NZ  . LYS A 1 155 ? -41.842 -21.543 -2.242  0.26 58.30  ? 418  LYS A NZ  1 
ATOM   981  N  N   . TRP A 1 156 ? -36.871 -25.942 -2.795  0.26 61.26  ? 419  TRP A N   1 
ATOM   982  C  CA  . TRP A 1 156 ? -37.173 -27.227 -3.488  0.26 62.76  ? 419  TRP A CA  1 
ATOM   983  C  C   . TRP A 1 156 ? -36.151 -28.295 -3.080  0.26 65.62  ? 419  TRP A C   1 
ATOM   984  O  O   . TRP A 1 156 ? -34.943 -27.983 -3.067  0.26 64.74  ? 419  TRP A O   1 
ATOM   985  C  CB  . TRP A 1 156 ? -37.192 -27.037 -5.011  0.26 61.48  ? 419  TRP A CB  1 
ATOM   986  C  CG  . TRP A 1 156 ? -38.028 -25.880 -5.462  0.26 60.15  ? 419  TRP A CG  1 
ATOM   987  C  CD1 . TRP A 1 156 ? -39.384 -25.855 -5.622  0.26 59.64  ? 419  TRP A CD1 1 
ATOM   988  C  CD2 . TRP A 1 156 ? -37.559 -24.562 -5.795  0.26 58.10  ? 419  TRP A CD2 1 
ATOM   989  N  NE1 . TRP A 1 156 ? -39.789 -24.616 -6.040  0.26 59.17  ? 419  TRP A NE1 1 
ATOM   990  C  CE2 . TRP A 1 156 ? -38.693 -23.801 -6.153  0.26 57.78  ? 419  TRP A CE2 1 
ATOM   991  C  CE3 . TRP A 1 156 ? -36.298 -23.954 -5.832  0.26 57.82  ? 419  TRP A CE3 1 
ATOM   992  C  CZ2 . TRP A 1 156 ? -38.598 -22.465 -6.539  0.26 58.16  ? 419  TRP A CZ2 1 
ATOM   993  C  CZ3 . TRP A 1 156 ? -36.206 -22.633 -6.211  0.26 57.42  ? 419  TRP A CZ3 1 
ATOM   994  C  CH2 . TRP A 1 156 ? -37.342 -21.901 -6.560  0.26 58.13  ? 419  TRP A CH2 1 
ATOM   995  N  N   . LYS A 1 157 ? -36.629 -29.508 -2.776  0.26 71.61  ? 420  LYS A N   1 
ATOM   996  C  CA  . LYS A 1 157 ? -35.800 -30.682 -2.384  0.26 76.08  ? 420  LYS A CA  1 
ATOM   997  C  C   . LYS A 1 157 ? -34.837 -31.020 -3.528  0.26 79.67  ? 420  LYS A C   1 
ATOM   998  O  O   . LYS A 1 157 ? -33.610 -30.912 -3.318  0.26 78.88  ? 420  LYS A O   1 
ATOM   999  C  CB  . LYS A 1 157 ? -36.704 -31.873 -2.048  0.26 77.47  ? 420  LYS A CB  1 
ATOM   1000 C  CG  . LYS A 1 157 ? -35.995 -33.148 -1.605  0.26 77.30  ? 420  LYS A CG  1 
ATOM   1001 C  CD  . LYS A 1 157 ? -36.776 -34.413 -1.917  0.26 77.76  ? 420  LYS A CD  1 
ATOM   1002 C  CE  . LYS A 1 157 ? -38.177 -34.418 -1.339  0.26 76.95  ? 420  LYS A CE  1 
ATOM   1003 N  NZ  . LYS A 1 157 ? -39.004 -35.499 -1.925  0.26 77.83  ? 420  LYS A NZ  1 
ATOM   1004 N  N   . SER A 1 158 ? -35.384 -31.402 -4.688  0.26 84.12  ? 421  SER A N   1 
ATOM   1005 C  CA  . SER A 1 158 ? -34.636 -31.806 -5.907  0.26 86.96  ? 421  SER A CA  1 
ATOM   1006 C  C   . SER A 1 158 ? -34.805 -30.743 -6.999  0.26 92.04  ? 421  SER A C   1 
ATOM   1007 O  O   . SER A 1 158 ? -35.544 -29.763 -6.769  0.26 91.60  ? 421  SER A O   1 
ATOM   1008 C  CB  . SER A 1 158 ? -35.086 -33.165 -6.387  0.26 85.96  ? 421  SER A CB  1 
ATOM   1009 O  OG  . SER A 1 158 ? -36.478 -33.172 -6.667  0.26 85.21  ? 421  SER A OG  1 
ATOM   1010 N  N   . ALA A 1 159 ? -34.127 -30.937 -8.135  1.00 101.13 ? 422  ALA A N   1 
ATOM   1011 C  CA  . ALA A 1 159 ? -34.278 -30.101 -9.349  1.00 97.32  ? 422  ALA A CA  1 
ATOM   1012 C  C   . ALA A 1 159 ? -35.631 -30.410 -10.012 1.00 87.44  ? 422  ALA A C   1 
ATOM   1013 O  O   . ALA A 1 159 ? -36.275 -29.499 -10.542 1.00 74.89  ? 422  ALA A O   1 
ATOM   1014 C  CB  . ALA A 1 159 ? -33.130 -30.376 -10.285 1.00 104.00 ? 422  ALA A CB  1 
ATOM   1015 N  N   . ARG A 1 160 ? -36.058 -31.675 -9.949  0.26 84.88  ? 423  ARG A N   1 
ATOM   1016 C  CA  . ARG A 1 160 ? -37.348 -32.164 -10.513 0.26 84.39  ? 423  ARG A CA  1 
ATOM   1017 C  C   . ARG A 1 160 ? -38.501 -31.271 -10.025 0.26 85.02  ? 423  ARG A C   1 
ATOM   1018 O  O   . ARG A 1 160 ? -39.372 -30.937 -10.851 0.26 85.17  ? 423  ARG A O   1 
ATOM   1019 C  CB  . ARG A 1 160 ? -37.574 -33.630 -10.125 0.26 83.41  ? 423  ARG A CB  1 
ATOM   1020 C  CG  . ARG A 1 160 ? -38.110 -34.501 -11.252 0.26 83.54  ? 423  ARG A CG  1 
ATOM   1021 C  CD  . ARG A 1 160 ? -38.072 -35.979 -10.905 0.26 83.08  ? 423  ARG A CD  1 
ATOM   1022 N  NE  . ARG A 1 160 ? -36.720 -36.447 -10.610 0.26 82.78  ? 423  ARG A NE  1 
ATOM   1023 C  CZ  . ARG A 1 160 ? -35.890 -37.026 -11.479 0.26 81.61  ? 423  ARG A CZ  1 
ATOM   1024 N  NH1 . ARG A 1 160 ? -34.686 -37.403 -11.081 0.26 80.40  ? 423  ARG A NH1 1 
ATOM   1025 N  NH2 . ARG A 1 160 ? -36.253 -37.233 -12.734 0.26 82.05  ? 423  ARG A NH2 1 
ATOM   1026 N  N   . GLU A 1 161 ? -38.460 -30.841 -8.761  0.26 85.50  ? 424  GLU A N   1 
ATOM   1027 C  CA  . GLU A 1 161 ? -39.555 -30.015 -8.186  0.26 84.62  ? 424  GLU A CA  1 
ATOM   1028 C  C   . GLU A 1 161 ? -39.443 -28.570 -8.677  0.26 81.82  ? 424  GLU A C   1 
ATOM   1029 O  O   . GLU A 1 161 ? -40.472 -28.016 -9.105  0.26 82.24  ? 424  GLU A O   1 
ATOM   1030 C  CB  . GLU A 1 161 ? -39.478 -30.039 -6.660  0.26 87.55  ? 424  GLU A CB  1 
ATOM   1031 C  CG  . GLU A 1 161 ? -39.279 -31.431 -6.090  0.26 90.35  ? 424  GLU A CG  1 
ATOM   1032 C  CD  . GLU A 1 161 ? -39.036 -31.467 -4.592  0.26 91.71  ? 424  GLU A CD  1 
ATOM   1033 O  OE1 . GLU A 1 161 ? -38.906 -30.383 -3.990  0.26 91.83  ? 424  GLU A OE1 1 
ATOM   1034 O  OE2 . GLU A 1 161 ? -38.980 -32.578 -4.032  0.26 91.48  ? 424  GLU A OE2 1 
ATOM   1035 N  N   . ALA A 1 162 ? -38.245 -27.984 -8.613  0.26 79.28  ? 425  ALA A N   1 
ATOM   1036 C  CA  . ALA A 1 162 ? -38.070 -26.560 -8.984  0.26 77.99  ? 425  ALA A CA  1 
ATOM   1037 C  C   . ALA A 1 162 ? -38.544 -26.323 -10.419 0.26 75.87  ? 425  ALA A C   1 
ATOM   1038 O  O   . ALA A 1 162 ? -39.209 -25.298 -10.658 0.26 74.16  ? 425  ALA A O   1 
ATOM   1039 C  CB  . ALA A 1 162 ? -36.623 -26.169 -8.820  0.26 77.47  ? 425  ALA A CB  1 
ATOM   1040 N  N   . VAL A 1 163 ? -38.213 -27.237 -11.333 0.26 75.59  ? 426  VAL A N   1 
ATOM   1041 C  CA  . VAL A 1 163 ? -38.568 -27.048 -12.770 0.26 76.70  ? 426  VAL A CA  1 
ATOM   1042 C  C   . VAL A 1 163 ? -40.092 -26.981 -12.887 0.26 77.75  ? 426  VAL A C   1 
ATOM   1043 O  O   . VAL A 1 163 ? -40.580 -26.445 -13.898 0.26 78.42  ? 426  VAL A O   1 
ATOM   1044 C  CB  . VAL A 1 163 ? -37.982 -28.177 -13.638 0.26 76.45  ? 426  VAL A CB  1 
ATOM   1045 C  CG1 . VAL A 1 163 ? -38.917 -29.373 -13.722 0.26 75.82  ? 426  VAL A CG1 1 
ATOM   1046 C  CG2 . VAL A 1 163 ? -37.615 -27.684 -15.027 0.26 75.94  ? 426  VAL A CG2 1 
ATOM   1047 N  N   . GLU A 1 164 ? -40.806 -27.498 -11.885 0.26 79.70  ? 427  GLU A N   1 
ATOM   1048 C  CA  . GLU A 1 164 ? -42.292 -27.529 -11.930 0.26 81.12  ? 427  GLU A CA  1 
ATOM   1049 C  C   . GLU A 1 164 ? -42.859 -26.399 -11.063 0.26 81.85  ? 427  GLU A C   1 
ATOM   1050 O  O   . GLU A 1 164 ? -44.072 -26.424 -10.789 0.26 81.87  ? 427  GLU A O   1 
ATOM   1051 C  CB  . GLU A 1 164 ? -42.782 -28.905 -11.478 0.26 80.70  ? 427  GLU A CB  1 
ATOM   1052 C  CG  . GLU A 1 164 ? -42.238 -30.031 -12.337 0.26 81.80  ? 427  GLU A CG  1 
ATOM   1053 C  CD  . GLU A 1 164 ? -42.298 -31.413 -11.710 0.26 83.43  ? 427  GLU A CD  1 
ATOM   1054 O  OE1 . GLU A 1 164 ? -42.739 -31.515 -10.549 0.26 82.41  ? 427  GLU A OE1 1 
ATOM   1055 O  OE2 . GLU A 1 164 ? -41.897 -32.382 -12.384 0.26 84.61  ? 427  GLU A OE2 1 
ATOM   1056 N  N   . ASP A 1 165 ? -42.014 -25.446 -10.656 0.26 84.78  ? 428  ASP A N   1 
ATOM   1057 C  CA  . ASP A 1 165 ? -42.480 -24.286 -9.848  0.26 84.90  ? 428  ASP A CA  1 
ATOM   1058 C  C   . ASP A 1 165 ? -42.270 -22.996 -10.644 0.26 86.38  ? 428  ASP A C   1 
ATOM   1059 O  O   . ASP A 1 165 ? -41.136 -22.768 -11.105 0.26 88.05  ? 428  ASP A O   1 
ATOM   1060 C  CB  . ASP A 1 165 ? -41.775 -24.224 -8.492  0.26 85.78  ? 428  ASP A CB  1 
ATOM   1061 C  CG  . ASP A 1 165 ? -41.965 -22.895 -7.783  0.26 85.90  ? 428  ASP A CG  1 
ATOM   1062 O  OD1 . ASP A 1 165 ? -41.169 -21.974 -8.046  0.26 85.63  ? 428  ASP A OD1 1 
ATOM   1063 O  OD2 . ASP A 1 165 ? -42.910 -22.792 -6.978  0.26 88.44  ? 428  ASP A OD2 1 
ATOM   1064 N  N   . SER A 1 166 ? -43.319 -22.181 -10.780 0.26 86.19  ? 429  SER A N   1 
ATOM   1065 C  CA  . SER A 1 166 ? -43.231 -20.936 -11.585 0.26 85.56  ? 429  SER A CA  1 
ATOM   1066 C  C   . SER A 1 166 ? -42.263 -19.946 -10.932 0.26 84.78  ? 429  SER A C   1 
ATOM   1067 O  O   . SER A 1 166 ? -41.579 -19.219 -11.675 0.26 85.79  ? 429  SER A O   1 
ATOM   1068 C  CB  . SER A 1 166 ? -44.593 -20.327 -11.770 0.26 87.08  ? 429  SER A CB  1 
ATOM   1069 O  OG  . SER A 1 166 ? -45.479 -21.254 -12.379 0.26 89.64  ? 429  SER A OG  1 
ATOM   1070 N  N   . GLY A 1 167 ? -42.215 -19.918 -9.598  0.26 83.84  ? 430  GLY A N   1 
ATOM   1071 C  CA  . GLY A 1 167 ? -41.343 -18.962 -8.890  0.26 82.35  ? 430  GLY A CA  1 
ATOM   1072 C  C   . GLY A 1 167 ? -39.899 -19.111 -9.327  0.26 80.99  ? 430  GLY A C   1 
ATOM   1073 O  O   . GLY A 1 167 ? -39.230 -18.079 -9.505  0.26 80.38  ? 430  GLY A O   1 
ATOM   1074 N  N   . PHE A 1 168 ? -39.443 -20.352 -9.507  0.26 80.57  ? 431  PHE A N   1 
ATOM   1075 C  CA  . PHE A 1 168 ? -38.053 -20.606 -9.965  0.26 80.38  ? 431  PHE A CA  1 
ATOM   1076 C  C   . PHE A 1 168 ? -37.820 -19.872 -11.285 0.26 77.34  ? 431  PHE A C   1 
ATOM   1077 O  O   . PHE A 1 168 ? -36.806 -19.164 -11.410 0.26 77.27  ? 431  PHE A O   1 
ATOM   1078 C  CB  . PHE A 1 168 ? -37.826 -22.111 -10.124 0.26 81.70  ? 431  PHE A CB  1 
ATOM   1079 C  CG  . PHE A 1 168 ? -36.580 -22.499 -10.880 0.26 81.43  ? 431  PHE A CG  1 
ATOM   1080 C  CD1 . PHE A 1 168 ? -35.365 -22.629 -10.227 0.26 81.06  ? 431  PHE A CD1 1 
ATOM   1081 C  CD2 . PHE A 1 168 ? -36.625 -22.747 -12.242 0.26 81.74  ? 431  PHE A CD2 1 
ATOM   1082 C  CE1 . PHE A 1 168 ? -34.222 -22.991 -10.922 0.26 80.81  ? 431  PHE A CE1 1 
ATOM   1083 C  CE2 . PHE A 1 168 ? -35.482 -23.107 -12.936 0.26 82.00  ? 431  PHE A CE2 1 
ATOM   1084 C  CZ  . PHE A 1 168 ? -34.282 -23.230 -12.275 0.26 81.85  ? 431  PHE A CZ  1 
ATOM   1085 N  N   . TRP A 1 169 ? -38.744 -20.031 -12.234 0.26 76.13  ? 432  TRP A N   1 
ATOM   1086 C  CA  . TRP A 1 169 ? -38.583 -19.397 -13.568 0.26 75.91  ? 432  TRP A CA  1 
ATOM   1087 C  C   . TRP A 1 169 ? -38.670 -17.874 -13.428 0.26 76.42  ? 432  TRP A C   1 
ATOM   1088 O  O   . TRP A 1 169 ? -38.014 -17.174 -14.221 0.26 77.78  ? 432  TRP A O   1 
ATOM   1089 C  CB  . TRP A 1 169 ? -39.609 -19.969 -14.552 0.26 74.23  ? 432  TRP A CB  1 
ATOM   1090 C  CG  . TRP A 1 169 ? -39.446 -21.444 -14.754 0.26 74.28  ? 432  TRP A CG  1 
ATOM   1091 C  CD1 . TRP A 1 169 ? -40.273 -22.434 -14.309 0.26 74.70  ? 432  TRP A CD1 1 
ATOM   1092 C  CD2 . TRP A 1 169 ? -38.359 -22.103 -15.427 0.26 73.89  ? 432  TRP A CD2 1 
ATOM   1093 N  NE1 . TRP A 1 169 ? -39.786 -23.660 -14.673 0.26 73.93  ? 432  TRP A NE1 1 
ATOM   1094 C  CE2 . TRP A 1 169 ? -38.613 -23.489 -15.360 0.26 73.50  ? 432  TRP A CE2 1 
ATOM   1095 C  CE3 . TRP A 1 169 ? -37.207 -21.661 -16.085 0.26 73.81  ? 432  TRP A CE3 1 
ATOM   1096 C  CZ2 . TRP A 1 169 ? -37.755 -24.430 -15.927 0.26 73.34  ? 432  TRP A CZ2 1 
ATOM   1097 C  CZ3 . TRP A 1 169 ? -36.360 -22.591 -16.645 0.26 72.92  ? 432  TRP A CZ3 1 
ATOM   1098 C  CH2 . TRP A 1 169 ? -36.632 -23.956 -16.566 0.26 72.84  ? 432  TRP A CH2 1 
ATOM   1099 N  N   . GLU A 1 170 ? -39.440 -17.385 -12.454 0.26 76.49  ? 433  GLU A N   1 
ATOM   1100 C  CA  . GLU A 1 170 ? -39.498 -15.920 -12.204 0.26 77.02  ? 433  GLU A CA  1 
ATOM   1101 C  C   . GLU A 1 170 ? -38.113 -15.460 -11.743 0.26 76.56  ? 433  GLU A C   1 
ATOM   1102 O  O   . GLU A 1 170 ? -37.638 -14.426 -12.246 0.26 76.51  ? 433  GLU A O   1 
ATOM   1103 C  CB  . GLU A 1 170 ? -40.571 -15.604 -11.161 0.26 76.16  ? 433  GLU A CB  1 
ATOM   1104 C  CG  . GLU A 1 170 ? -41.921 -16.215 -11.487 0.26 75.72  ? 433  GLU A CG  1 
ATOM   1105 C  CD  . GLU A 1 170 ? -42.950 -16.116 -10.375 0.26 74.96  ? 433  GLU A CD  1 
ATOM   1106 O  OE1 . GLU A 1 170 ? -42.746 -15.301 -9.453  0.26 74.38  ? 433  GLU A OE1 1 
ATOM   1107 O  OE2 . GLU A 1 170 ? -43.949 -16.860 -10.429 0.26 70.93  ? 433  GLU A OE2 1 
ATOM   1108 N  N   . LEU A 1 171 ? -37.497 -16.202 -10.821 0.26 76.64  ? 434  LEU A N   1 
ATOM   1109 C  CA  . LEU A 1 171 ? -36.117 -15.873 -10.380 0.26 77.95  ? 434  LEU A CA  1 
ATOM   1110 C  C   . LEU A 1 171 ? -35.219 -15.907 -11.615 0.26 77.84  ? 434  LEU A C   1 
ATOM   1111 O  O   . LEU A 1 171 ? -34.417 -14.972 -11.792 0.26 75.93  ? 434  LEU A O   1 
ATOM   1112 C  CB  . LEU A 1 171 ? -35.674 -16.923 -9.358  0.26 77.90  ? 434  LEU A CB  1 
ATOM   1113 C  CG  . LEU A 1 171 ? -36.634 -17.155 -8.193  0.26 78.29  ? 434  LEU A CG  1 
ATOM   1114 C  CD1 . LEU A 1 171 ? -36.209 -18.363 -7.374  0.26 78.32  ? 434  LEU A CD1 1 
ATOM   1115 C  CD2 . LEU A 1 171 ? -36.730 -15.918 -7.315  0.26 78.26  ? 434  LEU A CD2 1 
ATOM   1116 N  N   . VAL A 1 172 ? -35.368 -16.948 -12.435 0.26 77.12  ? 435  VAL A N   1 
ATOM   1117 C  CA  . VAL A 1 172 ? -34.570 -17.083 -13.691 0.26 75.12  ? 435  VAL A CA  1 
ATOM   1118 C  C   . VAL A 1 172 ? -34.750 -15.808 -14.524 0.26 75.16  ? 435  VAL A C   1 
ATOM   1119 O  O   . VAL A 1 172 ? -33.730 -15.266 -14.992 0.26 73.26  ? 435  VAL A O   1 
ATOM   1120 C  CB  . VAL A 1 172 ? -34.972 -18.337 -14.492 0.26 75.94  ? 435  VAL A CB  1 
ATOM   1121 C  CG1 . VAL A 1 172 ? -34.354 -18.343 -15.883 0.26 75.71  ? 435  VAL A CG1 1 
ATOM   1122 C  CG2 . VAL A 1 172 ? -34.624 -19.619 -13.749 0.26 76.70  ? 435  VAL A CG2 1 
ATOM   1123 N  N   . ASP A 1 173 ? -35.999 -15.357 -14.690 0.26 76.43  ? 436  ASP A N   1 
ATOM   1124 C  CA  . ASP A 1 173 ? -36.371 -14.135 -15.456 0.26 76.21  ? 436  ASP A CA  1 
ATOM   1125 C  C   . ASP A 1 173 ? -35.615 -12.926 -14.891 0.26 73.21  ? 436  ASP A C   1 
ATOM   1126 O  O   . ASP A 1 173 ? -35.082 -12.136 -15.697 0.26 72.68  ? 436  ASP A O   1 
ATOM   1127 C  CB  . ASP A 1 173 ? -37.882 -13.884 -15.422 0.26 79.01  ? 436  ASP A CB  1 
ATOM   1128 C  CG  . ASP A 1 173 ? -38.702 -14.871 -16.236 0.26 81.53  ? 436  ASP A CG  1 
ATOM   1129 O  OD1 . ASP A 1 173 ? -38.210 -15.317 -17.294 0.26 82.38  ? 436  ASP A OD1 1 
ATOM   1130 O  OD2 . ASP A 1 173 ? -39.831 -15.187 -15.804 0.26 84.21  ? 436  ASP A OD2 1 
ATOM   1131 N  N   . LYS A 1 174 ? -35.580 -12.789 -13.562 0.26 70.74  ? 437  LYS A N   1 
ATOM   1132 C  CA  . LYS A 1 174 ? -34.914 -11.660 -12.859 0.26 70.63  ? 437  LYS A CA  1 
ATOM   1133 C  C   . LYS A 1 174 ? -33.428 -11.654 -13.238 0.26 70.07  ? 437  LYS A C   1 
ATOM   1134 O  O   . LYS A 1 174 ? -32.937 -10.590 -13.679 0.26 69.97  ? 437  LYS A O   1 
ATOM   1135 C  CB  . LYS A 1 174 ? -35.106 -11.767 -11.342 0.26 71.57  ? 437  LYS A CB  1 
ATOM   1136 C  CG  . LYS A 1 174 ? -34.601 -10.573 -10.542 0.26 73.69  ? 437  LYS A CG  1 
ATOM   1137 C  CD  . LYS A 1 174 ? -34.829 -10.703 -9.051  0.26 75.73  ? 437  LYS A CD  1 
ATOM   1138 C  CE  . LYS A 1 174 ? -34.155 -9.607  -8.253  0.26 77.04  ? 437  LYS A CE  1 
ATOM   1139 N  NZ  . LYS A 1 174 ? -34.352 -9.793  -6.796  0.26 78.78  ? 437  LYS A NZ  1 
ATOM   1140 N  N   . GLU A 1 175 ? -32.756 -12.802 -13.090 1.00 67.27  ? 438  GLU A N   1 
ATOM   1141 C  CA  . GLU A 1 175 ? -31.317 -12.950 -13.434 1.00 65.24  ? 438  GLU A CA  1 
ATOM   1142 C  C   . GLU A 1 175 ? -31.103 -12.753 -14.936 1.00 60.02  ? 438  GLU A C   1 
ATOM   1143 O  O   . GLU A 1 175 ? -30.136 -12.028 -15.312 1.00 56.54  ? 438  GLU A O   1 
ATOM   1144 C  CB  . GLU A 1 175 ? -30.827 -14.314 -12.977 1.00 71.37  ? 438  GLU A CB  1 
ATOM   1145 C  CG  . GLU A 1 175 ? -30.024 -14.212 -11.707 1.00 77.13  ? 438  GLU A CG  1 
ATOM   1146 C  CD  . GLU A 1 175 ? -28.628 -13.709 -11.966 1.00 73.96  ? 438  GLU A CD  1 
ATOM   1147 O  OE1 . GLU A 1 175 ? -27.989 -14.253 -12.882 1.00 76.82  ? 438  GLU A OE1 1 
ATOM   1148 O  OE2 . GLU A 1 175 ? -28.207 -12.777 -11.271 1.00 72.64  ? 438  GLU A OE2 1 
ATOM   1149 N  N   . ARG A 1 176 ? -31.965 -13.368 -15.755 1.00 55.80  ? 439  ARG A N   1 
ATOM   1150 C  CA  . ARG A 1 176 ? -31.922 -13.241 -17.233 1.00 55.15  ? 439  ARG A CA  1 
ATOM   1151 C  C   . ARG A 1 176 ? -31.911 -11.755 -17.591 1.00 58.09  ? 439  ARG A C   1 
ATOM   1152 O  O   . ARG A 1 176 ? -30.987 -11.332 -18.305 1.00 63.82  ? 439  ARG A O   1 
ATOM   1153 C  CB  . ARG A 1 176 ? -33.097 -13.984 -17.864 1.00 60.18  ? 439  ARG A CB  1 
ATOM   1154 C  CG  . ARG A 1 176 ? -32.958 -14.219 -19.360 1.00 64.06  ? 439  ARG A CG  1 
ATOM   1155 C  CD  . ARG A 1 176 ? -33.764 -15.450 -19.714 1.00 65.24  ? 439  ARG A CD  1 
ATOM   1156 N  NE  . ARG A 1 176 ? -34.387 -15.354 -21.016 1.00 80.47  ? 439  ARG A NE  1 
ATOM   1157 C  CZ  . ARG A 1 176 ? -35.296 -16.213 -21.467 1.00 101.82 ? 439  ARG A CZ  1 
ATOM   1158 N  NH1 . ARG A 1 176 ? -35.657 -17.242 -20.710 1.00 99.05  ? 439  ARG A NH1 1 
ATOM   1159 N  NH2 . ARG A 1 176 ? -35.839 -16.036 -22.666 1.00 95.81  ? 439  ARG A NH2 1 
ATOM   1160 N  N   . ASN A 1 177 ? -32.857 -10.970 -17.061 1.00 63.93  ? 440  ASN A N   1 
ATOM   1161 C  CA  . ASN A 1 177 ? -32.968 -9.512  -17.362 1.00 63.02  ? 440  ASN A CA  1 
ATOM   1162 C  C   . ASN A 1 177 ? -31.741 -8.790  -16.795 1.00 55.57  ? 440  ASN A C   1 
ATOM   1163 O  O   . ASN A 1 177 ? -31.246 -7.863  -17.458 1.00 53.84  ? 440  ASN A O   1 
ATOM   1164 C  CB  . ASN A 1 177 ? -34.300 -8.930  -16.878 1.00 67.21  ? 440  ASN A CB  1 
ATOM   1165 C  CG  . ASN A 1 177 ? -35.463 -9.399  -17.731 1.00 71.97  ? 440  ASN A CG  1 
ATOM   1166 O  OD1 . ASN A 1 177 ? -35.409 -9.322  -18.959 1.00 71.14  ? 440  ASN A OD1 1 
ATOM   1167 N  ND2 . ASN A 1 177 ? -36.508 -9.907  -17.098 1.00 72.90  ? 440  ASN A ND2 1 
ATOM   1168 N  N   . LEU A 1 178 ? -31.241 -9.239  -15.642 1.00 54.61  ? 441  LEU A N   1 
ATOM   1169 C  CA  . LEU A 1 178 ? -29.958 -8.764  -15.062 1.00 58.65  ? 441  LEU A CA  1 
ATOM   1170 C  C   . LEU A 1 178 ? -28.810 -8.990  -16.055 1.00 62.74  ? 441  LEU A C   1 
ATOM   1171 O  O   . LEU A 1 178 ? -28.049 -8.021  -16.310 1.00 59.95  ? 441  LEU A O   1 
ATOM   1172 C  CB  . LEU A 1 178 ? -29.725 -9.459  -13.718 1.00 63.44  ? 441  LEU A CB  1 
ATOM   1173 C  CG  . LEU A 1 178 ? -30.400 -8.779  -12.527 1.00 69.50  ? 441  LEU A CG  1 
ATOM   1174 C  CD1 . LEU A 1 178 ? -30.282 -9.611  -11.252 1.00 72.93  ? 441  LEU A CD1 1 
ATOM   1175 C  CD2 . LEU A 1 178 ? -29.813 -7.389  -12.313 1.00 75.15  ? 441  LEU A CD2 1 
ATOM   1176 N  N   . HIS A 1 179 ? -28.693 -10.187 -16.634 1.00 62.25  ? 442  HIS A N   1 
ATOM   1177 C  CA  . HIS A 1 179 ? -27.640 -10.499 -17.647 1.00 65.56  ? 442  HIS A CA  1 
ATOM   1178 C  C   . HIS A 1 179 ? -27.800 -9.619  -18.903 1.00 60.93  ? 442  HIS A C   1 
ATOM   1179 O  O   . HIS A 1 179 ? -26.765 -9.224  -19.472 1.00 63.48  ? 442  HIS A O   1 
ATOM   1180 C  CB  . HIS A 1 179 ? -27.604 -12.002 -17.999 1.00 64.73  ? 442  HIS A CB  1 
ATOM   1181 C  CG  . HIS A 1 179 ? -27.037 -12.886 -16.926 1.00 64.32  ? 442  HIS A CG  1 
ATOM   1182 N  ND1 . HIS A 1 179 ? -26.996 -14.265 -17.051 1.00 52.52  ? 442  HIS A ND1 1 
ATOM   1183 C  CD2 . HIS A 1 179 ? -26.505 -12.600 -15.714 1.00 57.26  ? 442  HIS A CD2 1 
ATOM   1184 C  CE1 . HIS A 1 179 ? -26.455 -14.777 -15.969 1.00 55.35  ? 442  HIS A CE1 1 
ATOM   1185 N  NE2 . HIS A 1 179 ? -26.129 -13.775 -15.142 1.00 53.33  ? 442  HIS A NE2 1 
ATOM   1186 N  N   . LEU A 1 180 ? -29.023 -9.304  -19.344 1.00 62.13  ? 443  LEU A N   1 
ATOM   1187 C  CA  . LEU A 1 180 ? -29.230 -8.412  -20.530 1.00 62.05  ? 443  LEU A CA  1 
ATOM   1188 C  C   . LEU A 1 180 ? -28.739 -7.005  -20.164 1.00 64.17  ? 443  LEU A C   1 
ATOM   1189 O  O   . LEU A 1 180 ? -28.229 -6.313  -21.045 1.00 63.89  ? 443  LEU A O   1 
ATOM   1190 C  CB  . LEU A 1 180 ? -30.699 -8.427  -20.964 1.00 58.77  ? 443  LEU A CB  1 
ATOM   1191 C  CG  . LEU A 1 180 ? -31.247 -9.781  -21.438 1.00 61.79  ? 443  LEU A CG  1 
ATOM   1192 C  CD1 . LEU A 1 180 ? -32.763 -9.787  -21.455 1.00 63.43  ? 443  LEU A CD1 1 
ATOM   1193 C  CD2 . LEU A 1 180 ? -30.742 -10.155 -22.823 1.00 62.04  ? 443  LEU A CD2 1 
ATOM   1194 N  N   . GLU A 1 181 ? -28.791 -6.664  -18.876 1.00 71.95  ? 444  GLU A N   1 
ATOM   1195 C  CA  . GLU A 1 181 ? -28.382 -5.359  -18.289 1.00 81.12  ? 444  GLU A CA  1 
ATOM   1196 C  C   . GLU A 1 181 ? -26.859 -5.316  -18.066 1.00 83.12  ? 444  GLU A C   1 
ATOM   1197 O  O   . GLU A 1 181 ? -26.365 -4.247  -17.658 1.00 85.83  ? 444  GLU A O   1 
ATOM   1198 C  CB  . GLU A 1 181 ? -29.122 -5.182  -16.958 1.00 92.73  ? 444  GLU A CB  1 
ATOM   1199 C  CG  . GLU A 1 181 ? -29.781 -3.832  -16.736 1.00 98.23  ? 444  GLU A CG  1 
ATOM   1200 C  CD  . GLU A 1 181 ? -30.568 -3.783  -15.430 1.00 110.83 ? 444  GLU A CD  1 
ATOM   1201 O  OE1 . GLU A 1 181 ? -30.281 -2.896  -14.590 1.00 110.84 ? 444  GLU A OE1 1 
ATOM   1202 O  OE2 . GLU A 1 181 ? -31.457 -4.652  -15.234 1.00 110.96 ? 444  GLU A OE2 1 
ATOM   1203 N  N   . GLY A 1 182 ? -26.144 -6.430  -18.277 1.00 75.72  ? 445  GLY A N   1 
ATOM   1204 C  CA  . GLY A 1 182 ? -24.679 -6.523  -18.104 1.00 65.85  ? 445  GLY A CA  1 
ATOM   1205 C  C   . GLY A 1 182 ? -24.276 -6.754  -16.651 1.00 64.31  ? 445  GLY A C   1 
ATOM   1206 O  O   . GLY A 1 182 ? -23.134 -6.396  -16.286 1.00 69.25  ? 445  GLY A O   1 
ATOM   1207 N  N   . LYS A 1 183 ? -25.158 -7.346  -15.847 1.00 54.16  ? 446  LYS A N   1 
ATOM   1208 C  CA  . LYS A 1 183 ? -24.964 -7.542  -14.386 1.00 59.88  ? 446  LYS A CA  1 
ATOM   1209 C  C   . LYS A 1 183 ? -25.368 -8.961  -13.966 1.00 51.18  ? 446  LYS A C   1 
ATOM   1210 O  O   . LYS A 1 183 ? -26.132 -9.612  -14.675 1.00 47.60  ? 446  LYS A O   1 
ATOM   1211 C  CB  . LYS A 1 183 ? -25.843 -6.585  -13.573 1.00 68.16  ? 446  LYS A CB  1 
ATOM   1212 C  CG  . LYS A 1 183 ? -25.609 -5.102  -13.797 1.00 72.31  ? 446  LYS A CG  1 
ATOM   1213 C  CD  . LYS A 1 183 ? -26.852 -4.280  -13.514 1.00 84.15  ? 446  LYS A CD  1 
ATOM   1214 C  CE  . LYS A 1 183 ? -26.977 -3.056  -14.396 1.00 90.50  ? 446  LYS A CE  1 
ATOM   1215 N  NZ  . LYS A 1 183 ? -26.437 -1.848  -13.730 1.00 99.27  ? 446  LYS A NZ  1 
ATOM   1216 N  N   . CYS A 1 184 ? -24.948 -9.367  -12.774 1.00 53.70  ? 447  CYS A N   1 
ATOM   1217 C  CA  . CYS A 1 184 ? -25.115 -10.732 -12.223 1.00 55.66  ? 447  CYS A CA  1 
ATOM   1218 C  C   . CYS A 1 184 ? -25.278 -10.659 -10.703 1.00 56.03  ? 447  CYS A C   1 
ATOM   1219 O  O   . CYS A 1 184 ? -24.534 -9.884  -10.076 1.00 58.41  ? 447  CYS A O   1 
ATOM   1220 C  CB  . CYS A 1 184 ? -23.887 -11.577 -12.570 1.00 56.71  ? 447  CYS A CB  1 
ATOM   1221 S  SG  . CYS A 1 184 ? -24.119 -13.350 -12.271 1.00 55.89  ? 447  CYS A SG  1 
ATOM   1222 N  N   . GLU A 1 185 ? -26.115 -11.525 -10.132 1.00 56.02  ? 448  GLU A N   1 
ATOM   1223 C  CA  . GLU A 1 185 ? -26.421 -11.535 -8.679  1.00 63.45  ? 448  GLU A CA  1 
ATOM   1224 C  C   . GLU A 1 185 ? -26.285 -12.949 -8.098  1.00 68.55  ? 448  GLU A C   1 
ATOM   1225 O  O   . GLU A 1 185 ? -25.875 -13.060 -6.922  1.00 67.15  ? 448  GLU A O   1 
ATOM   1226 C  CB  . GLU A 1 185 ? -27.838 -10.980 -8.472  1.00 73.30  ? 448  GLU A CB  1 
ATOM   1227 C  CG  . GLU A 1 185 ? -28.241 -10.805 -7.016  1.00 75.49  ? 448  GLU A CG  1 
ATOM   1228 C  CD  . GLU A 1 185 ? -29.635 -10.232 -6.802  1.00 84.34  ? 448  GLU A CD  1 
ATOM   1229 O  OE1 . GLU A 1 185 ? -29.851 -9.076  -7.212  1.00 80.60  ? 448  GLU A OE1 1 
ATOM   1230 O  OE2 . GLU A 1 185 ? -30.507 -10.949 -6.235  1.00 89.55  ? 448  GLU A OE2 1 
ATOM   1231 N  N   . THR A 1 186 ? -26.653 -13.995 -8.841  1.00 64.31  ? 449  THR A N   1 
ATOM   1232 C  CA  . THR A 1 186 ? -26.887 -15.333 -8.241  1.00 69.42  ? 449  THR A CA  1 
ATOM   1233 C  C   . THR A 1 186 ? -26.031 -16.423 -8.894  1.00 61.49  ? 449  THR A C   1 
ATOM   1234 O  O   . THR A 1 186 ? -26.198 -17.569 -8.504  1.00 69.56  ? 449  THR A O   1 
ATOM   1235 C  CB  . THR A 1 186 ? -28.366 -15.707 -8.346  1.00 75.44  ? 449  THR A CB  1 
ATOM   1236 O  OG1 . THR A 1 186 ? -28.669 -15.740 -9.739  1.00 81.34  ? 449  THR A OG1 1 
ATOM   1237 C  CG2 . THR A 1 186 ? -29.272 -14.732 -7.632  1.00 78.97  ? 449  THR A CG2 1 
ATOM   1238 N  N   . CYS A 1 187 ? -25.153 -16.095 -9.838  1.00 59.16  ? 450  CYS A N   1 
ATOM   1239 C  CA  . CYS A 1 187 ? -24.329 -17.096 -10.563 1.00 53.49  ? 450  CYS A CA  1 
ATOM   1240 C  C   . CYS A 1 187 ? -22.991 -17.275 -9.826  1.00 51.93  ? 450  CYS A C   1 
ATOM   1241 O  O   . CYS A 1 187 ? -21.969 -16.649 -10.188 1.00 46.75  ? 450  CYS A O   1 
ATOM   1242 C  CB  . CYS A 1 187 ? -24.237 -16.709 -12.028 1.00 52.21  ? 450  CYS A CB  1 
ATOM   1243 S  SG  . CYS A 1 187 ? -25.895 -16.540 -12.744 1.00 61.17  ? 450  CYS A SG  1 
ATOM   1244 N  N   . VAL A 1 188 ? -23.021 -18.121 -8.798  1.00 53.45  ? 451  VAL A N   1 
ATOM   1245 C  CA  . VAL A 1 188 ? -21.880 -18.352 -7.870  1.00 59.34  ? 451  VAL A CA  1 
ATOM   1246 C  C   . VAL A 1 188 ? -21.505 -19.834 -7.867  1.00 57.22  ? 451  VAL A C   1 
ATOM   1247 O  O   . VAL A 1 188 ? -22.369 -20.686 -7.616  1.00 52.76  ? 451  VAL A O   1 
ATOM   1248 C  CB  . VAL A 1 188 ? -22.206 -17.857 -6.453  1.00 61.66  ? 451  VAL A CB  1 
ATOM   1249 C  CG1 . VAL A 1 188 ? -21.213 -18.403 -5.425  1.00 65.18  ? 451  VAL A CG1 1 
ATOM   1250 C  CG2 . VAL A 1 188 ? -22.256 -16.338 -6.439  1.00 62.74  ? 451  VAL A CG2 1 
ATOM   1251 N  N   . TYR A 1 189 ? -20.227 -20.108 -8.094  1.00 62.46  ? 452  TYR A N   1 
ATOM   1252 C  CA  . TYR A 1 189 ? -19.688 -21.487 -8.098  1.00 67.97  ? 452  TYR A CA  1 
ATOM   1253 C  C   . TYR A 1 189 ? -19.596 -21.986 -6.652  1.00 66.31  ? 452  TYR A C   1 
ATOM   1254 O  O   . TYR A 1 189 ? -19.386 -21.179 -5.742  1.00 69.46  ? 452  TYR A O   1 
ATOM   1255 C  CB  . TYR A 1 189 ? -18.386 -21.510 -8.898  1.00 64.32  ? 452  TYR A CB  1 
ATOM   1256 C  CG  . TYR A 1 189 ? -18.600 -21.383 -10.384 1.00 61.54  ? 452  TYR A CG  1 
ATOM   1257 C  CD1 . TYR A 1 189 ? -19.281 -22.363 -11.082 1.00 68.01  ? 452  TYR A CD1 1 
ATOM   1258 C  CD2 . TYR A 1 189 ? -18.119 -20.293 -11.093 1.00 65.05  ? 452  TYR A CD2 1 
ATOM   1259 C  CE1 . TYR A 1 189 ? -19.481 -22.263 -12.449 1.00 75.74  ? 452  TYR A CE1 1 
ATOM   1260 C  CE2 . TYR A 1 189 ? -18.300 -20.183 -12.463 1.00 65.46  ? 452  TYR A CE2 1 
ATOM   1261 C  CZ  . TYR A 1 189 ? -18.994 -21.168 -13.141 1.00 72.61  ? 452  TYR A CZ  1 
ATOM   1262 O  OH  . TYR A 1 189 ? -19.202 -21.067 -14.486 1.00 87.15  ? 452  TYR A OH  1 
ATOM   1263 N  N   . ASN A 1 190 ? -19.826 -23.289 -6.465  1.00 76.87  ? 453  ASN A N   1 
ATOM   1264 C  CA  . ASN A 1 190 ? -19.639 -24.046 -5.198  1.00 75.91  ? 453  ASN A CA  1 
ATOM   1265 C  C   . ASN A 1 190 ? -18.600 -25.148 -5.431  1.00 75.56  ? 453  ASN A C   1 
ATOM   1266 O  O   . ASN A 1 190 ? -18.930 -26.114 -6.126  1.00 68.62  ? 453  ASN A O   1 
ATOM   1267 C  CB  . ASN A 1 190 ? -20.956 -24.639 -4.712  1.00 70.63  ? 453  ASN A CB  1 
ATOM   1268 C  CG  . ASN A 1 190 ? -22.014 -23.583 -4.500  1.00 68.73  ? 453  ASN A CG  1 
ATOM   1269 O  OD1 . ASN A 1 190 ? -22.273 -22.754 -5.369  1.00 81.53  ? 453  ASN A OD1 1 
ATOM   1270 N  ND2 . ASN A 1 190 ? -22.658 -23.626 -3.352  1.00 69.21  ? 453  ASN A ND2 1 
ATOM   1271 N  N   . MET A 1 191 ? -17.392 -24.983 -4.888  1.00 91.29  ? 454  MET A N   1 
ATOM   1272 C  CA  . MET A 1 191 ? -16.213 -25.850 -5.160  1.00 102.55 ? 454  MET A CA  1 
ATOM   1273 C  C   . MET A 1 191 ? -16.307 -27.083 -4.258  1.00 108.71 ? 454  MET A C   1 
ATOM   1274 O  O   . MET A 1 191 ? -16.601 -26.885 -3.067  1.00 108.70 ? 454  MET A O   1 
ATOM   1275 C  CB  . MET A 1 191 ? -14.922 -25.081 -4.867  1.00 107.24 ? 454  MET A CB  1 
ATOM   1276 C  CG  . MET A 1 191 ? -13.652 -25.826 -5.219  1.00 122.09 ? 454  MET A CG  1 
ATOM   1277 S  SD  . MET A 1 191 ? -12.163 -24.799 -5.006  1.00 145.50 ? 454  MET A SD  1 
ATOM   1278 C  CE  . MET A 1 191 ? -12.203 -23.818 -6.505  1.00 140.38 ? 454  MET A CE  1 
ATOM   1279 N  N   . MET A 1 192 ? -16.095 -28.287 -4.816  1.00 119.53 ? 455  MET A N   1 
ATOM   1280 C  CA  . MET A 1 192 ? -16.170 -29.603 -4.107  1.00 118.34 ? 455  MET A CA  1 
ATOM   1281 C  C   . MET A 1 192 ? -15.382 -30.678 -4.880  1.00 117.74 ? 455  MET A C   1 
ATOM   1282 O  O   . MET A 1 192 ? -15.883 -31.149 -5.930  1.00 102.83 ? 455  MET A O   1 
ATOM   1283 C  CB  . MET A 1 192 ? -17.624 -30.059 -3.930  1.00 111.26 ? 455  MET A CB  1 
ATOM   1284 C  CG  . MET A 1 192 ? -18.257 -29.574 -2.643  1.00 107.87 ? 455  MET A CG  1 
ATOM   1285 S  SD  . MET A 1 192 ? -20.062 -29.536 -2.724  1.00 117.46 ? 455  MET A SD  1 
ATOM   1286 C  CE  . MET A 1 192 ? -20.440 -31.284 -2.574  1.00 118.12 ? 455  MET A CE  1 
ATOM   1287 N  N   . ALA A 1 210 ? -12.191 -31.805 -8.626  0.26 66.87  ? 473  ALA A N   1 
ATOM   1288 C  CA  . ALA A 1 210 ? -12.695 -30.417 -8.491  0.26 66.73  ? 473  ALA A CA  1 
ATOM   1289 C  C   . ALA A 1 210 ? -13.895 -30.210 -9.425  0.26 65.20  ? 473  ALA A C   1 
ATOM   1290 O  O   . ALA A 1 210 ? -13.676 -30.071 -10.645 0.26 64.58  ? 473  ALA A O   1 
ATOM   1291 C  CB  . ALA A 1 210 ? -11.583 -29.438 -8.786  0.26 65.80  ? 473  ALA A CB  1 
ATOM   1292 N  N   . ILE A 1 211 ? -15.111 -30.188 -8.864  0.26 64.73  ? 474  ILE A N   1 
ATOM   1293 C  CA  . ILE A 1 211 ? -16.402 -30.043 -9.606  0.26 65.15  ? 474  ILE A CA  1 
ATOM   1294 C  C   . ILE A 1 211 ? -17.160 -28.843 -9.024  0.26 66.29  ? 474  ILE A C   1 
ATOM   1295 O  O   . ILE A 1 211 ? -17.470 -28.867 -7.816  0.26 66.37  ? 474  ILE A O   1 
ATOM   1296 C  CB  . ILE A 1 211 ? -17.239 -31.340 -9.536  0.26 64.61  ? 474  ILE A CB  1 
ATOM   1297 C  CG1 . ILE A 1 211 ? -16.384 -32.597 -9.729  0.26 65.03  ? 474  ILE A CG1 1 
ATOM   1298 C  CG2 . ILE A 1 211 ? -18.393 -31.288 -10.528 0.26 63.06  ? 474  ILE A CG2 1 
ATOM   1299 C  CD1 . ILE A 1 211 ? -15.828 -33.181 -8.447  0.26 65.27  ? 474  ILE A CD1 1 
ATOM   1300 N  N   . TRP A 1 212 ? -17.449 -27.838 -9.857  0.26 67.26  ? 475  TRP A N   1 
ATOM   1301 C  CA  . TRP A 1 212 ? -18.014 -26.526 -9.441  0.26 68.14  ? 475  TRP A CA  1 
ATOM   1302 C  C   . TRP A 1 212 ? -19.523 -26.495 -9.721  0.26 67.95  ? 475  TRP A C   1 
ATOM   1303 O  O   . TRP A 1 212 ? -19.906 -26.240 -10.881 0.26 66.80  ? 475  TRP A O   1 
ATOM   1304 C  CB  . TRP A 1 212 ? -17.268 -25.386 -10.149 0.26 68.80  ? 475  TRP A CB  1 
ATOM   1305 C  CG  . TRP A 1 212 ? -15.817 -25.271 -9.781  0.26 69.55  ? 475  TRP A CG  1 
ATOM   1306 C  CD1 . TRP A 1 212 ? -15.098 -26.092 -8.959  0.26 69.62  ? 475  TRP A CD1 1 
ATOM   1307 C  CD2 . TRP A 1 212 ? -14.888 -24.282 -10.259 0.26 68.59  ? 475  TRP A CD2 1 
ATOM   1308 N  NE1 . TRP A 1 212 ? -13.798 -25.673 -8.880  0.26 69.56  ? 475  TRP A NE1 1 
ATOM   1309 C  CE2 . TRP A 1 212 ? -13.637 -24.566 -9.669  0.26 68.20  ? 475  TRP A CE2 1 
ATOM   1310 C  CE3 . TRP A 1 212 ? -14.992 -23.181 -11.116 0.26 68.65  ? 475  TRP A CE3 1 
ATOM   1311 C  CZ2 . TRP A 1 212 ? -12.504 -23.792 -9.915  0.26 67.93  ? 475  TRP A CZ2 1 
ATOM   1312 C  CZ3 . TRP A 1 212 ? -13.870 -22.419 -11.360 0.26 68.89  ? 475  TRP A CZ3 1 
ATOM   1313 C  CH2 . TRP A 1 212 ? -12.643 -22.724 -10.770 0.26 68.44  ? 475  TRP A CH2 1 
ATOM   1314 N  N   . TYR A 1 213 ? -20.337 -26.747 -8.689  0.26 68.77  ? 476  TYR A N   1 
ATOM   1315 C  CA  . TYR A 1 213 ? -21.824 -26.717 -8.735  0.26 70.17  ? 476  TYR A CA  1 
ATOM   1316 C  C   . TYR A 1 213 ? -22.321 -25.266 -8.736  0.26 68.71  ? 476  TYR A C   1 
ATOM   1317 O  O   . TYR A 1 213 ? -21.735 -24.425 -8.028  0.26 68.26  ? 476  TYR A O   1 
ATOM   1318 C  CB  . TYR A 1 213 ? -22.434 -27.463 -7.542  0.26 73.33  ? 476  TYR A CB  1 
ATOM   1319 C  CG  . TYR A 1 213 ? -22.476 -28.964 -7.675  0.26 75.42  ? 476  TYR A CG  1 
ATOM   1320 C  CD1 . TYR A 1 213 ? -23.514 -29.594 -8.346  0.26 77.75  ? 476  TYR A CD1 1 
ATOM   1321 C  CD2 . TYR A 1 213 ? -21.489 -29.762 -7.119  0.26 77.22  ? 476  TYR A CD2 1 
ATOM   1322 C  CE1 . TYR A 1 213 ? -23.564 -30.973 -8.472  0.26 78.85  ? 476  TYR A CE1 1 
ATOM   1323 C  CE2 . TYR A 1 213 ? -21.524 -31.143 -7.234  0.26 78.49  ? 476  TYR A CE2 1 
ATOM   1324 C  CZ  . TYR A 1 213 ? -22.565 -31.751 -7.914  0.26 79.38  ? 476  TYR A CZ  1 
ATOM   1325 O  OH  . TYR A 1 213 ? -22.617 -33.110 -8.036  0.26 79.85  ? 476  TYR A OH  1 
ATOM   1326 N  N   . MET A 1 214 ? -23.367 -24.993 -9.522  0.26 67.41  ? 477  MET A N   1 
ATOM   1327 C  CA  . MET A 1 214 ? -24.214 -23.771 -9.431  0.26 66.10  ? 477  MET A CA  1 
ATOM   1328 C  C   . MET A 1 214 ? -25.645 -24.222 -9.121  0.26 63.72  ? 477  MET A C   1 
ATOM   1329 O  O   . MET A 1 214 ? -25.942 -25.414 -9.350  0.26 62.67  ? 477  MET A O   1 
ATOM   1330 C  CB  . MET A 1 214 ? -24.216 -22.972 -10.739 0.26 66.65  ? 477  MET A CB  1 
ATOM   1331 C  CG  . MET A 1 214 ? -22.855 -22.838 -11.396 0.26 67.11  ? 477  MET A CG  1 
ATOM   1332 S  SD  . MET A 1 214 ? -22.942 -21.892 -12.941 0.26 67.70  ? 477  MET A SD  1 
ATOM   1333 C  CE  . MET A 1 214 ? -22.726 -20.226 -12.314 0.26 65.38  ? 477  MET A CE  1 
ATOM   1334 N  N   . TRP A 1 215 ? -26.493 -23.316 -8.627  0.26 62.76  ? 478  TRP A N   1 
ATOM   1335 C  CA  . TRP A 1 215 ? -27.937 -23.589 -8.391  0.26 63.50  ? 478  TRP A CA  1 
ATOM   1336 C  C   . TRP A 1 215 ? -28.652 -23.680 -9.746  0.26 62.19  ? 478  TRP A C   1 
ATOM   1337 O  O   . TRP A 1 215 ? -28.218 -22.998 -10.696 0.26 60.88  ? 478  TRP A O   1 
ATOM   1338 C  CB  . TRP A 1 215 ? -28.563 -22.547 -7.450  0.26 63.28  ? 478  TRP A CB  1 
ATOM   1339 C  CG  . TRP A 1 215 ? -28.952 -21.257 -8.103  0.26 64.13  ? 478  TRP A CG  1 
ATOM   1340 C  CD1 . TRP A 1 215 ? -28.116 -20.263 -8.520  0.26 64.63  ? 478  TRP A CD1 1 
ATOM   1341 C  CD2 . TRP A 1 215 ? -30.288 -20.808 -8.395  0.26 64.55  ? 478  TRP A CD2 1 
ATOM   1342 N  NE1 . TRP A 1 215 ? -28.838 -19.234 -9.063  0.26 66.97  ? 478  TRP A NE1 1 
ATOM   1343 C  CE2 . TRP A 1 215 ? -30.173 -19.537 -8.998  0.26 66.04  ? 478  TRP A CE2 1 
ATOM   1344 C  CE3 . TRP A 1 215 ? -31.564 -21.353 -8.209  0.26 65.13  ? 478  TRP A CE3 1 
ATOM   1345 C  CZ2 . TRP A 1 215 ? -31.286 -18.807 -9.417  0.26 65.26  ? 478  TRP A CZ2 1 
ATOM   1346 C  CZ3 . TRP A 1 215 ? -32.663 -20.633 -8.627  0.26 65.22  ? 478  TRP A CZ3 1 
ATOM   1347 C  CH2 . TRP A 1 215 ? -32.523 -19.377 -9.222  0.26 66.01  ? 478  TRP A CH2 1 
ATOM   1348 N  N   . LEU A 1 216 ? -29.706 -24.498 -9.818  0.26 61.44  ? 479  LEU A N   1 
ATOM   1349 C  CA  . LEU A 1 216 ? -30.356 -24.965 -11.076 0.26 62.22  ? 479  LEU A CA  1 
ATOM   1350 C  C   . LEU A 1 216 ? -30.627 -23.795 -12.035 0.26 61.67  ? 479  LEU A C   1 
ATOM   1351 O  O   . LEU A 1 216 ? -30.575 -24.021 -13.259 0.26 61.89  ? 479  LEU A O   1 
ATOM   1352 C  CB  . LEU A 1 216 ? -31.655 -25.695 -10.718 0.26 61.88  ? 479  LEU A CB  1 
ATOM   1353 C  CG  . LEU A 1 216 ? -32.204 -26.620 -11.802 0.26 63.11  ? 479  LEU A CG  1 
ATOM   1354 C  CD1 . LEU A 1 216 ? -31.282 -27.811 -12.016 0.26 64.06  ? 479  LEU A CD1 1 
ATOM   1355 C  CD2 . LEU A 1 216 ? -33.607 -27.090 -11.452 0.26 63.33  ? 479  LEU A CD2 1 
ATOM   1356 N  N   . GLY A 1 217 ? -30.922 -22.604 -11.503 1.00 59.91  ? 480  GLY A N   1 
ATOM   1357 C  CA  . GLY A 1 217 ? -31.224 -21.409 -12.308 1.00 60.41  ? 480  GLY A CA  1 
ATOM   1358 C  C   . GLY A 1 217 ? -30.058 -20.964 -13.160 1.00 58.63  ? 480  GLY A C   1 
ATOM   1359 O  O   . GLY A 1 217 ? -30.254 -20.754 -14.375 1.00 57.83  ? 480  GLY A O   1 
ATOM   1360 N  N   . ALA A 1 218 ? -28.886 -20.827 -12.544 1.00 58.14  ? 481  ALA A N   1 
ATOM   1361 C  CA  . ALA A 1 218 ? -27.614 -20.487 -13.229 1.00 54.68  ? 481  ALA A CA  1 
ATOM   1362 C  C   . ALA A 1 218 ? -27.265 -21.543 -14.295 1.00 53.16  ? 481  ALA A C   1 
ATOM   1363 O  O   . ALA A 1 218 ? -26.775 -21.153 -15.388 1.00 51.69  ? 481  ALA A O   1 
ATOM   1364 C  CB  . ALA A 1 218 ? -26.528 -20.320 -12.217 1.00 48.72  ? 481  ALA A CB  1 
ATOM   1365 N  N   . ARG A 1 219 ? -27.542 -22.821 -14.003 0.26 52.61  ? 482  ARG A N   1 
ATOM   1366 C  CA  . ARG A 1 219 ? -27.307 -23.971 -14.922 0.26 53.61  ? 482  ARG A CA  1 
ATOM   1367 C  C   . ARG A 1 219 ? -28.121 -23.768 -16.204 0.26 53.57  ? 482  ARG A C   1 
ATOM   1368 O  O   . ARG A 1 219 ? -27.544 -23.922 -17.298 0.26 52.69  ? 482  ARG A O   1 
ATOM   1369 C  CB  . ARG A 1 219 ? -27.700 -25.309 -14.285 0.26 54.02  ? 482  ARG A CB  1 
ATOM   1370 C  CG  . ARG A 1 219 ? -27.062 -25.580 -12.930 0.26 55.62  ? 482  ARG A CG  1 
ATOM   1371 C  CD  . ARG A 1 219 ? -27.444 -26.936 -12.366 0.26 56.21  ? 482  ARG A CD  1 
ATOM   1372 N  NE  . ARG A 1 219 ? -26.381 -27.925 -12.482 0.26 55.85  ? 482  ARG A NE  1 
ATOM   1373 C  CZ  . ARG A 1 219 ? -26.265 -29.014 -11.724 0.26 57.48  ? 482  ARG A CZ  1 
ATOM   1374 N  NH1 . ARG A 1 219 ? -27.152 -29.270 -10.775 0.26 57.55  ? 482  ARG A NH1 1 
ATOM   1375 N  NH2 . ARG A 1 219 ? -25.251 -29.842 -11.911 0.26 58.08  ? 482  ARG A NH2 1 
ATOM   1376 N  N   . PHE A 1 220 ? -29.412 -23.441 -16.067 0.26 52.77  ? 483  PHE A N   1 
ATOM   1377 C  CA  . PHE A 1 220 ? -30.345 -23.218 -17.202 0.26 50.96  ? 483  PHE A CA  1 
ATOM   1378 C  C   . PHE A 1 220 ? -29.833 -22.074 -18.087 0.26 49.79  ? 483  PHE A C   1 
ATOM   1379 O  O   . PHE A 1 220 ? -29.834 -22.231 -19.322 0.26 48.93  ? 483  PHE A O   1 
ATOM   1380 C  CB  . PHE A 1 220 ? -31.765 -22.902 -16.728 0.26 51.44  ? 483  PHE A CB  1 
ATOM   1381 C  CG  . PHE A 1 220 ? -32.660 -22.455 -17.855 0.26 51.09  ? 483  PHE A CG  1 
ATOM   1382 C  CD1 . PHE A 1 220 ? -33.018 -23.339 -18.860 0.26 52.15  ? 483  PHE A CD1 1 
ATOM   1383 C  CD2 . PHE A 1 220 ? -33.086 -21.140 -17.948 0.26 51.67  ? 483  PHE A CD2 1 
ATOM   1384 C  CE1 . PHE A 1 220 ? -33.814 -22.928 -19.917 0.26 53.68  ? 483  PHE A CE1 1 
ATOM   1385 C  CE2 . PHE A 1 220 ? -33.885 -20.730 -19.005 0.26 53.74  ? 483  PHE A CE2 1 
ATOM   1386 C  CZ  . PHE A 1 220 ? -34.245 -21.623 -19.989 0.26 54.00  ? 483  PHE A CZ  1 
ATOM   1387 N  N   . LEU A 1 221 ? -29.434 -20.956 -17.473 0.26 49.38  ? 484  LEU A N   1 
ATOM   1388 C  CA  . LEU A 1 221 ? -28.932 -19.747 -18.183 0.26 49.55  ? 484  LEU A CA  1 
ATOM   1389 C  C   . LEU A 1 221 ? -27.651 -20.098 -18.952 0.26 49.06  ? 484  LEU A C   1 
ATOM   1390 O  O   . LEU A 1 221 ? -27.461 -19.546 -20.058 0.26 48.51  ? 484  LEU A O   1 
ATOM   1391 C  CB  . LEU A 1 221 ? -28.696 -18.618 -17.174 0.26 49.19  ? 484  LEU A CB  1 
ATOM   1392 C  CG  . LEU A 1 221 ? -29.957 -17.989 -16.578 0.26 49.63  ? 484  LEU A CG  1 
ATOM   1393 C  CD1 . LEU A 1 221 ? -29.601 -16.964 -15.510 0.26 49.91  ? 484  LEU A CD1 1 
ATOM   1394 C  CD2 . LEU A 1 221 ? -30.816 -17.346 -17.658 0.26 49.34  ? 484  LEU A CD2 1 
ATOM   1395 N  N   . GLU A 1 222 ? -26.813 -20.977 -18.388 1.00 47.49  ? 485  GLU A N   1 
ATOM   1396 C  CA  . GLU A 1 222 ? -25.621 -21.517 -19.095 1.00 47.62  ? 485  GLU A CA  1 
ATOM   1397 C  C   . GLU A 1 222 ? -26.116 -22.366 -20.285 1.00 44.48  ? 485  GLU A C   1 
ATOM   1398 O  O   . GLU A 1 222 ? -25.662 -22.116 -21.435 1.00 45.41  ? 485  GLU A O   1 
ATOM   1399 C  CB  . GLU A 1 222 ? -24.720 -22.305 -18.138 1.00 50.88  ? 485  GLU A CB  1 
ATOM   1400 C  CG  . GLU A 1 222 ? -23.622 -23.080 -18.854 1.00 51.90  ? 485  GLU A CG  1 
ATOM   1401 C  CD  . GLU A 1 222 ? -22.657 -23.764 -17.916 1.00 53.70  ? 485  GLU A CD  1 
ATOM   1402 O  OE1 . GLU A 1 222 ? -21.490 -23.306 -17.844 1.00 51.32  ? 485  GLU A OE1 1 
ATOM   1403 O  OE2 . GLU A 1 222 ? -23.074 -24.752 -17.268 1.00 54.25  ? 485  GLU A OE2 1 
ATOM   1404 N  N   . PHE A 1 223 ? -27.071 -23.270 -20.033 1.00 43.06  ? 486  PHE A N   1 
ATOM   1405 C  CA  . PHE A 1 223 ? -27.679 -24.219 -21.009 1.00 43.47  ? 486  PHE A CA  1 
ATOM   1406 C  C   . PHE A 1 223 ? -28.368 -23.479 -22.157 1.00 47.93  ? 486  PHE A C   1 
ATOM   1407 O  O   . PHE A 1 223 ? -28.214 -23.901 -23.332 1.00 44.75  ? 486  PHE A O   1 
ATOM   1408 C  CB  . PHE A 1 223 ? -28.699 -25.110 -20.311 1.00 42.97  ? 486  PHE A CB  1 
ATOM   1409 C  CG  . PHE A 1 223 ? -29.389 -26.098 -21.211 1.00 44.77  ? 486  PHE A CG  1 
ATOM   1410 C  CD1 . PHE A 1 223 ? -28.678 -27.116 -21.821 1.00 42.50  ? 486  PHE A CD1 1 
ATOM   1411 C  CD2 . PHE A 1 223 ? -30.755 -26.006 -21.444 1.00 45.13  ? 486  PHE A CD2 1 
ATOM   1412 C  CE1 . PHE A 1 223 ? -29.314 -28.005 -22.677 1.00 45.19  ? 486  PHE A CE1 1 
ATOM   1413 C  CE2 . PHE A 1 223 ? -31.395 -26.911 -22.275 1.00 40.91  ? 486  PHE A CE2 1 
ATOM   1414 C  CZ  . PHE A 1 223 ? -30.675 -27.909 -22.892 1.00 46.54  ? 486  PHE A CZ  1 
ATOM   1415 N  N   . GLU A 1 224 ? -29.112 -22.428 -21.812 1.00 48.68  ? 487  GLU A N   1 
ATOM   1416 C  CA  . GLU A 1 224 ? -29.860 -21.548 -22.750 1.00 51.76  ? 487  GLU A CA  1 
ATOM   1417 C  C   . GLU A 1 224 ? -28.888 -21.014 -23.800 1.00 48.67  ? 487  GLU A C   1 
ATOM   1418 O  O   . GLU A 1 224 ? -29.224 -20.986 -25.011 1.00 49.82  ? 487  GLU A O   1 
ATOM   1419 C  CB  . GLU A 1 224 ? -30.509 -20.381 -21.996 1.00 56.89  ? 487  GLU A CB  1 
ATOM   1420 C  CG  . GLU A 1 224 ? -31.274 -19.409 -22.887 1.00 64.25  ? 487  GLU A CG  1 
ATOM   1421 C  CD  . GLU A 1 224 ? -32.194 -18.442 -22.146 1.00 65.89  ? 487  GLU A CD  1 
ATOM   1422 O  OE1 . GLU A 1 224 ? -33.420 -18.554 -22.333 1.00 61.21  ? 487  GLU A OE1 1 
ATOM   1423 O  OE2 . GLU A 1 224 ? -31.686 -17.574 -21.387 1.00 63.92  ? 487  GLU A OE2 1 
ATOM   1424 N  N   . ALA A 1 225 ? -27.713 -20.610 -23.348 1.00 41.67  ? 488  ALA A N   1 
ATOM   1425 C  CA  . ALA A 1 225 ? -26.817 -19.748 -24.135 1.00 40.86  ? 488  ALA A CA  1 
ATOM   1426 C  C   . ALA A 1 225 ? -25.836 -20.612 -24.924 1.00 39.72  ? 488  ALA A C   1 
ATOM   1427 O  O   . ALA A 1 225 ? -25.474 -20.185 -26.063 1.00 39.37  ? 488  ALA A O   1 
ATOM   1428 C  CB  . ALA A 1 225 ? -26.136 -18.760 -23.220 1.00 42.09  ? 488  ALA A CB  1 
ATOM   1429 N  N   . LEU A 1 226 ? -25.444 -21.765 -24.366 1.00 42.30  ? 489  LEU A N   1 
ATOM   1430 C  CA  . LEU A 1 226 ? -24.286 -22.575 -24.859 1.00 39.94  ? 489  LEU A CA  1 
ATOM   1431 C  C   . LEU A 1 226 ? -24.627 -24.054 -25.057 1.00 36.44  ? 489  LEU A C   1 
ATOM   1432 O  O   . LEU A 1 226 ? -23.802 -24.766 -25.700 1.00 38.88  ? 489  LEU A O   1 
ATOM   1433 C  CB  . LEU A 1 226 ? -23.135 -22.384 -23.871 1.00 38.68  ? 489  LEU A CB  1 
ATOM   1434 C  CG  . LEU A 1 226 ? -22.638 -20.940 -23.751 1.00 43.17  ? 489  LEU A CG  1 
ATOM   1435 C  CD1 . LEU A 1 226 ? -21.520 -20.797 -22.706 1.00 43.51  ? 489  LEU A CD1 1 
ATOM   1436 C  CD2 . LEU A 1 226 ? -22.132 -20.442 -25.093 1.00 44.77  ? 489  LEU A CD2 1 
ATOM   1437 N  N   . GLY A 1 227 ? -25.787 -24.507 -24.571 1.00 33.27  ? 490  GLY A N   1 
ATOM   1438 C  CA  . GLY A 1 227 ? -26.297 -25.884 -24.743 1.00 30.69  ? 490  GLY A CA  1 
ATOM   1439 C  C   . GLY A 1 227 ? -26.223 -26.370 -26.177 1.00 29.36  ? 490  GLY A C   1 
ATOM   1440 O  O   . GLY A 1 227 ? -26.051 -27.572 -26.395 1.00 33.40  ? 490  GLY A O   1 
ATOM   1441 N  N   . PHE A 1 228 ? -26.297 -25.470 -27.150 1.00 33.59  ? 491  PHE A N   1 
ATOM   1442 C  CA  . PHE A 1 228 ? -26.395 -25.863 -28.579 1.00 36.07  ? 491  PHE A CA  1 
ATOM   1443 C  C   . PHE A 1 228 ? -25.126 -26.633 -28.975 1.00 33.44  ? 491  PHE A C   1 
ATOM   1444 O  O   . PHE A 1 228 ? -25.207 -27.480 -29.842 1.00 35.62  ? 491  PHE A O   1 
ATOM   1445 C  CB  . PHE A 1 228 ? -26.667 -24.641 -29.470 1.00 35.95  ? 491  PHE A CB  1 
ATOM   1446 C  CG  . PHE A 1 228 ? -25.504 -23.704 -29.592 1.00 33.93  ? 491  PHE A CG  1 
ATOM   1447 C  CD1 . PHE A 1 228 ? -25.321 -22.680 -28.682 1.00 34.90  ? 491  PHE A CD1 1 
ATOM   1448 C  CD2 . PHE A 1 228 ? -24.549 -23.905 -30.568 1.00 35.60  ? 491  PHE A CD2 1 
ATOM   1449 C  CE1 . PHE A 1 228 ? -24.226 -21.842 -28.776 1.00 33.94  ? 491  PHE A CE1 1 
ATOM   1450 C  CE2 . PHE A 1 228 ? -23.456 -23.061 -30.662 1.00 34.39  ? 491  PHE A CE2 1 
ATOM   1451 C  CZ  . PHE A 1 228 ? -23.285 -22.051 -29.755 1.00 35.00  ? 491  PHE A CZ  1 
ATOM   1452 N  N   . LEU A 1 229 ? -23.985 -26.300 -28.373 1.00 35.85  ? 492  LEU A N   1 
ATOM   1453 C  CA  . LEU A 1 229 ? -22.662 -26.909 -28.687 1.00 36.38  ? 492  LEU A CA  1 
ATOM   1454 C  C   . LEU A 1 229 ? -22.740 -28.421 -28.516 1.00 34.41  ? 492  LEU A C   1 
ATOM   1455 O  O   . LEU A 1 229 ? -22.338 -29.157 -29.473 1.00 33.02  ? 492  LEU A O   1 
ATOM   1456 C  CB  . LEU A 1 229 ? -21.616 -26.302 -27.750 1.00 37.26  ? 492  LEU A CB  1 
ATOM   1457 C  CG  . LEU A 1 229 ? -21.164 -24.884 -28.099 1.00 36.31  ? 492  LEU A CG  1 
ATOM   1458 C  CD1 . LEU A 1 229 ? -20.244 -24.364 -27.021 1.00 34.43  ? 492  LEU A CD1 1 
ATOM   1459 C  CD2 . LEU A 1 229 ? -20.504 -24.838 -29.487 1.00 37.62  ? 492  LEU A CD2 1 
ATOM   1460 N  N   . ASN A 1 230 ? -23.282 -28.859 -27.371 1.00 33.07  ? 493  ASN A N   1 
ATOM   1461 C  CA  . ASN A 1 230 ? -23.517 -30.299 -27.097 1.00 33.64  ? 493  ASN A CA  1 
ATOM   1462 C  C   . ASN A 1 230 ? -24.784 -30.777 -27.814 1.00 33.04  ? 493  ASN A C   1 
ATOM   1463 O  O   . ASN A 1 230 ? -24.702 -31.768 -28.592 1.00 34.18  ? 493  ASN A O   1 
ATOM   1464 C  CB  . ASN A 1 230 ? -23.579 -30.585 -25.596 1.00 38.66  ? 493  ASN A CB  1 
ATOM   1465 C  CG  . ASN A 1 230 ? -23.699 -32.073 -25.332 1.00 44.72  ? 493  ASN A CG  1 
ATOM   1466 O  OD1 . ASN A 1 230 ? -24.742 -32.567 -24.877 1.00 48.41  ? 493  ASN A OD1 1 
ATOM   1467 N  ND2 . ASN A 1 230 ? -22.652 -32.807 -25.690 1.00 41.87  ? 493  ASN A ND2 1 
ATOM   1468 N  N   . GLU A 1 231 ? -25.920 -30.106 -27.597 1.00 36.30  ? 494  GLU A N   1 
ATOM   1469 C  CA  . GLU A 1 231 ? -27.254 -30.579 -28.098 1.00 35.42  ? 494  GLU A CA  1 
ATOM   1470 C  C   . GLU A 1 231 ? -27.256 -30.728 -29.628 1.00 35.69  ? 494  GLU A C   1 
ATOM   1471 O  O   . GLU A 1 231 ? -27.958 -31.617 -30.106 1.00 33.32  ? 494  GLU A O   1 
ATOM   1472 C  CB  . GLU A 1 231 ? -28.365 -29.594 -27.750 1.00 39.03  ? 494  GLU A CB  1 
ATOM   1473 C  CG  . GLU A 1 231 ? -28.796 -29.614 -26.295 1.00 43.67  ? 494  GLU A CG  1 
ATOM   1474 C  CD  . GLU A 1 231 ? -29.109 -30.990 -25.753 1.00 50.68  ? 494  GLU A CD  1 
ATOM   1475 O  OE1 . GLU A 1 231 ? -30.118 -31.603 -26.207 1.00 52.17  ? 494  GLU A OE1 1 
ATOM   1476 O  OE2 . GLU A 1 231 ? -28.302 -31.469 -24.920 1.00 61.38  ? 494  GLU A OE2 1 
ATOM   1477 N  N   . ASP A 1 232 ? -26.508 -29.894 -30.365 1.00 32.53  ? 495  ASP A N   1 
ATOM   1478 C  CA  . ASP A 1 232 ? -26.462 -29.960 -31.837 1.00 32.64  ? 495  ASP A CA  1 
ATOM   1479 C  C   . ASP A 1 232 ? -25.118 -30.517 -32.330 1.00 34.33  ? 495  ASP A C   1 
ATOM   1480 O  O   . ASP A 1 232 ? -24.828 -30.391 -33.542 1.00 31.78  ? 495  ASP A O   1 
ATOM   1481 C  CB  . ASP A 1 232 ? -26.781 -28.592 -32.437 1.00 36.21  ? 495  ASP A CB  1 
ATOM   1482 C  CG  . ASP A 1 232 ? -28.105 -27.989 -31.999 1.00 35.83  ? 495  ASP A CG  1 
ATOM   1483 O  OD1 . ASP A 1 232 ? -28.980 -28.742 -31.604 1.00 37.46  ? 495  ASP A OD1 1 
ATOM   1484 O  OD2 . ASP A 1 232 ? -28.226 -26.761 -32.040 1.00 37.71  ? 495  ASP A OD2 1 
ATOM   1485 N  N   . HIS A 1 233 ? -24.340 -31.186 -31.486 1.00 36.30  ? 496  HIS A N   1 
ATOM   1486 C  CA  . HIS A 1 233 ? -23.189 -32.006 -31.961 1.00 34.48  ? 496  HIS A CA  1 
ATOM   1487 C  C   . HIS A 1 233 ? -22.191 -31.153 -32.746 1.00 29.16  ? 496  HIS A C   1 
ATOM   1488 O  O   . HIS A 1 233 ? -21.791 -31.569 -33.826 1.00 34.39  ? 496  HIS A O   1 
ATOM   1489 C  CB  . HIS A 1 233 ? -23.702 -33.183 -32.807 1.00 36.19  ? 496  HIS A CB  1 
ATOM   1490 C  CG  . HIS A 1 233 ? -24.810 -33.891 -32.134 1.00 40.09  ? 496  HIS A CG  1 
ATOM   1491 N  ND1 . HIS A 1 233 ? -24.680 -34.361 -30.834 1.00 49.19  ? 496  HIS A ND1 1 
ATOM   1492 C  CD2 . HIS A 1 233 ? -26.099 -34.084 -32.485 1.00 45.34  ? 496  HIS A CD2 1 
ATOM   1493 C  CE1 . HIS A 1 233 ? -25.837 -34.875 -30.435 1.00 45.69  ? 496  HIS A CE1 1 
ATOM   1494 N  NE2 . HIS A 1 233 ? -26.720 -34.713 -31.426 1.00 42.06  ? 496  HIS A NE2 1 
ATOM   1495 N  N   . TRP A 1 234 ? -21.759 -30.019 -32.208 1.00 31.04  ? 497  TRP A N   1 
ATOM   1496 C  CA  . TRP A 1 234 ? -20.711 -29.160 -32.840 1.00 34.57  ? 497  TRP A CA  1 
ATOM   1497 C  C   . TRP A 1 234 ? -19.364 -29.908 -32.950 1.00 35.26  ? 497  TRP A C   1 
ATOM   1498 O  O   . TRP A 1 234 ? -18.600 -29.666 -33.918 1.00 32.50  ? 497  TRP A O   1 
ATOM   1499 C  CB  . TRP A 1 234 ? -20.605 -27.809 -32.122 1.00 35.11  ? 497  TRP A CB  1 
ATOM   1500 C  CG  . TRP A 1 234 ? -21.625 -26.828 -32.630 1.00 39.64  ? 497  TRP A CG  1 
ATOM   1501 C  CD1 . TRP A 1 234 ? -22.976 -27.014 -32.663 1.00 39.54  ? 497  TRP A CD1 1 
ATOM   1502 C  CD2 . TRP A 1 234 ? -21.387 -25.546 -33.240 1.00 37.59  ? 497  TRP A CD2 1 
ATOM   1503 N  NE1 . TRP A 1 234 ? -23.587 -25.937 -33.235 1.00 38.86  ? 497  TRP A NE1 1 
ATOM   1504 C  CE2 . TRP A 1 234 ? -22.649 -25.015 -33.586 1.00 39.63  ? 497  TRP A CE2 1 
ATOM   1505 C  CE3 . TRP A 1 234 ? -20.246 -24.771 -33.480 1.00 35.38  ? 497  TRP A CE3 1 
ATOM   1506 C  CZ2 . TRP A 1 234 ? -22.805 -23.752 -34.163 1.00 41.67  ? 497  TRP A CZ2 1 
ATOM   1507 C  CZ3 . TRP A 1 234 ? -20.396 -23.533 -34.070 1.00 36.62  ? 497  TRP A CZ3 1 
ATOM   1508 C  CH2 . TRP A 1 234 ? -21.656 -23.030 -34.405 1.00 39.30  ? 497  TRP A CH2 1 
ATOM   1509 N  N   . PHE A 1 235 ? -19.078 -30.782 -31.977 0.46 34.98  ? 498  PHE A N   1 
ATOM   1510 C  CA  . PHE A 1 235 ? -17.803 -31.536 -31.861 0.46 35.40  ? 498  PHE A CA  1 
ATOM   1511 C  C   . PHE A 1 235 ? -18.011 -32.996 -32.279 0.46 34.12  ? 498  PHE A C   1 
ATOM   1512 O  O   . PHE A 1 235 ? -17.282 -33.878 -31.801 0.46 35.60  ? 498  PHE A O   1 
ATOM   1513 C  CB  . PHE A 1 235 ? -17.259 -31.344 -30.448 0.46 35.13  ? 498  PHE A CB  1 
ATOM   1514 C  CG  . PHE A 1 235 ? -17.011 -29.891 -30.151 0.46 36.01  ? 498  PHE A CG  1 
ATOM   1515 C  CD1 . PHE A 1 235 ? -16.001 -29.206 -30.808 0.46 36.36  ? 498  PHE A CD1 1 
ATOM   1516 C  CD2 . PHE A 1 235 ? -17.817 -29.196 -29.266 0.46 35.36  ? 498  PHE A CD2 1 
ATOM   1517 C  CE1 . PHE A 1 235 ? -15.784 -27.862 -30.560 0.46 36.38  ? 498  PHE A CE1 1 
ATOM   1518 C  CE2 . PHE A 1 235 ? -17.592 -27.852 -29.015 0.46 35.24  ? 498  PHE A CE2 1 
ATOM   1519 C  CZ  . PHE A 1 235 ? -16.580 -27.188 -29.664 0.46 34.98  ? 498  PHE A CZ  1 
ATOM   1520 N  N   . SER A 1 236 ? -18.974 -33.223 -33.174 0.46 32.74  ? 499  SER A N   1 
ATOM   1521 C  CA  . SER A 1 236 ? -19.141 -34.465 -33.967 0.46 31.81  ? 499  SER A CA  1 
ATOM   1522 C  C   . SER A 1 236 ? -17.938 -34.636 -34.897 0.46 30.66  ? 499  SER A C   1 
ATOM   1523 O  O   . SER A 1 236 ? -17.444 -33.619 -35.399 0.46 30.34  ? 499  SER A O   1 
ATOM   1524 C  CB  . SER A 1 236 ? -20.392 -34.381 -34.775 0.46 31.79  ? 499  SER A CB  1 
ATOM   1525 O  OG  . SER A 1 236 ? -20.328 -33.250 -35.633 0.46 30.84  ? 499  SER A OG  1 
ATOM   1526 N  N   . ARG A 1 237 ? -17.513 -35.872 -35.153 0.46 30.59  ? 500  ARG A N   1 
ATOM   1527 C  CA  . ARG A 1 237 ? -16.399 -36.085 -36.114 0.46 31.08  ? 500  ARG A CA  1 
ATOM   1528 C  C   . ARG A 1 237 ? -16.789 -35.518 -37.485 0.46 30.99  ? 500  ARG A C   1 
ATOM   1529 O  O   . ARG A 1 237 ? -15.919 -34.937 -38.141 0.46 30.50  ? 500  ARG A O   1 
ATOM   1530 C  CB  . ARG A 1 237 ? -16.012 -37.564 -36.198 0.46 31.48  ? 500  ARG A CB  1 
ATOM   1531 C  CG  . ARG A 1 237 ? -14.661 -37.800 -36.855 0.46 30.99  ? 500  ARG A CG  1 
ATOM   1532 C  CD  . ARG A 1 237 ? -13.930 -38.999 -36.290 0.46 30.96  ? 500  ARG A CD  1 
ATOM   1533 N  NE  . ARG A 1 237 ? -12.545 -39.014 -36.732 0.46 29.77  ? 500  ARG A NE  1 
ATOM   1534 C  CZ  . ARG A 1 237 ? -11.555 -38.388 -36.111 0.46 30.39  ? 500  ARG A CZ  1 
ATOM   1535 N  NH1 . ARG A 1 237 ? -11.796 -37.694 -35.012 0.46 29.54  ? 500  ARG A NH1 1 
ATOM   1536 N  NH2 . ARG A 1 237 ? -10.327 -38.457 -36.590 0.46 30.91  ? 500  ARG A NH2 1 
ATOM   1537 N  N   . GLU A 1 238 ? -18.052 -35.673 -37.882 0.46 30.67  ? 501  GLU A N   1 
ATOM   1538 C  CA  . GLU A 1 238 ? -18.518 -35.194 -39.213 0.46 31.02  ? 501  GLU A CA  1 
ATOM   1539 C  C   . GLU A 1 238 ? -18.379 -33.672 -39.300 0.46 29.10  ? 501  GLU A C   1 
ATOM   1540 O  O   . GLU A 1 238 ? -18.004 -33.182 -40.372 0.46 26.87  ? 501  GLU A O   1 
ATOM   1541 C  CB  . GLU A 1 238 ? -19.966 -35.624 -39.455 0.46 32.86  ? 501  GLU A CB  1 
ATOM   1542 C  CG  . GLU A 1 238 ? -20.485 -35.266 -40.834 0.46 33.83  ? 501  GLU A CG  1 
ATOM   1543 C  CD  . GLU A 1 238 ? -21.949 -35.602 -41.059 0.46 36.93  ? 501  GLU A CD  1 
ATOM   1544 O  OE1 . GLU A 1 238 ? -22.796 -35.061 -40.323 0.46 40.12  ? 501  GLU A OE1 1 
ATOM   1545 O  OE2 . GLU A 1 238 ? -22.236 -36.411 -41.962 0.46 38.21  ? 501  GLU A OE2 1 
ATOM   1546 N  N   . ASN A 1 239 ? -18.650 -32.961 -38.206 0.46 30.16  ? 502  ASN A N   1 
ATOM   1547 C  CA  . ASN A 1 239 ? -18.615 -31.476 -38.225 0.46 31.26  ? 502  ASN A CA  1 
ATOM   1548 C  C   . ASN A 1 239 ? -17.237 -30.938 -37.826 0.46 30.16  ? 502  ASN A C   1 
ATOM   1549 O  O   . ASN A 1 239 ? -16.879 -29.873 -38.340 0.46 30.23  ? 502  ASN A O   1 
ATOM   1550 C  CB  . ASN A 1 239 ? -19.693 -30.886 -37.314 0.46 31.45  ? 502  ASN A CB  1 
ATOM   1551 C  CG  . ASN A 1 239 ? -19.881 -29.396 -37.494 0.46 33.62  ? 502  ASN A CG  1 
ATOM   1552 O  OD1 . ASN A 1 239 ? -20.310 -28.945 -38.552 0.46 31.81  ? 502  ASN A OD1 1 
ATOM   1553 N  ND2 . ASN A 1 239 ? -19.573 -28.627 -36.464 0.46 34.08  ? 502  ASN A ND2 1 
ATOM   1554 N  N   . SER A 1 240 ? -16.502 -31.632 -36.951 0.46 29.40  ? 503  SER A N   1 
ATOM   1555 C  CA  . SER A 1 240 ? -15.215 -31.097 -36.420 0.46 29.44  ? 503  SER A CA  1 
ATOM   1556 C  C   . SER A 1 240 ? -13.992 -31.808 -37.018 0.46 29.40  ? 503  SER A C   1 
ATOM   1557 O  O   . SER A 1 240 ? -12.905 -31.216 -36.942 0.46 29.18  ? 503  SER A O   1 
ATOM   1558 C  CB  . SER A 1 240 ? -15.199 -31.175 -34.914 0.46 29.55  ? 503  SER A CB  1 
ATOM   1559 O  OG  . SER A 1 240 ? -15.231 -32.522 -34.475 0.46 28.85  ? 503  SER A OG  1 
ATOM   1560 N  N   . LEU A 1 241 ? -14.155 -33.026 -37.547 0.46 29.51  ? 504  LEU A N   1 
ATOM   1561 C  CA  . LEU A 1 241 ? -13.045 -33.802 -38.176 0.46 30.44  ? 504  LEU A CA  1 
ATOM   1562 C  C   . LEU A 1 241 ? -12.113 -34.381 -37.101 0.46 30.72  ? 504  LEU A C   1 
ATOM   1563 O  O   . LEU A 1 241 ? -11.655 -35.514 -37.282 0.46 30.02  ? 504  LEU A O   1 
ATOM   1564 C  CB  . LEU A 1 241 ? -12.294 -32.889 -39.150 0.46 31.31  ? 504  LEU A CB  1 
ATOM   1565 C  CG  . LEU A 1 241 ? -13.116 -32.349 -40.319 0.46 32.14  ? 504  LEU A CG  1 
ATOM   1566 C  CD1 . LEU A 1 241 ? -12.240 -31.553 -41.272 0.46 33.01  ? 504  LEU A CD1 1 
ATOM   1567 C  CD2 . LEU A 1 241 ? -13.806 -33.481 -41.061 0.46 31.93  ? 504  LEU A CD2 1 
ATOM   1568 N  N   . SER A 1 242 ? -11.852 -33.631 -36.035 0.46 30.03  ? 505  SER A N   1 
ATOM   1569 C  CA  . SER A 1 242 ? -10.988 -34.064 -34.905 0.46 29.72  ? 505  SER A CA  1 
ATOM   1570 C  C   . SER A 1 242 ? -11.831 -34.657 -33.770 0.46 28.85  ? 505  SER A C   1 
ATOM   1571 O  O   . SER A 1 242 ? -11.313 -35.520 -33.034 0.46 27.32  ? 505  SER A O   1 
ATOM   1572 C  CB  . SER A 1 242 ? -10.147 -32.923 -34.392 0.46 29.85  ? 505  SER A CB  1 
ATOM   1573 O  OG  . SER A 1 242 ? -9.498  -32.256 -35.460 0.46 30.56  ? 505  SER A OG  1 
ATOM   1574 N  N   . GLY A 1 243 ? -13.069 -34.186 -33.615 1.00 29.72  ? 506  GLY A N   1 
ATOM   1575 C  CA  . GLY A 1 243 ? -13.921 -34.560 -32.473 1.00 27.60  ? 506  GLY A CA  1 
ATOM   1576 C  C   . GLY A 1 243 ? -14.454 -35.954 -32.572 1.00 28.63  ? 506  GLY A C   1 
ATOM   1577 O  O   . GLY A 1 243 ? -14.387 -36.569 -33.637 1.00 28.47  ? 506  GLY A O   1 
ATOM   1578 N  N   . VAL A 1 244 ? -14.949 -36.421 -31.442 1.00 31.29  ? 507  VAL A N   1 
ATOM   1579 C  CA  . VAL A 1 244 ? -15.587 -37.750 -31.273 1.00 33.28  ? 507  VAL A CA  1 
ATOM   1580 C  C   . VAL A 1 244 ? -16.889 -37.604 -30.438 1.00 33.51  ? 507  VAL A C   1 
ATOM   1581 O  O   . VAL A 1 244 ? -17.345 -38.614 -29.863 1.00 32.22  ? 507  VAL A O   1 
ATOM   1582 C  CB  . VAL A 1 244 ? -14.578 -38.712 -30.605 1.00 31.05  ? 507  VAL A CB  1 
ATOM   1583 C  CG1 . VAL A 1 244 ? -13.354 -38.987 -31.458 1.00 31.40  ? 507  VAL A CG1 1 
ATOM   1584 C  CG2 . VAL A 1 244 ? -14.141 -38.199 -29.249 1.00 29.23  ? 507  VAL A CG2 1 
ATOM   1585 N  N   . GLU A 1 245 ? -17.478 -36.417 -30.306 1.00 32.53  ? 508  GLU A N   1 
ATOM   1586 C  CA  . GLU A 1 245 ? -18.683 -36.272 -29.434 1.00 37.98  ? 508  GLU A CA  1 
ATOM   1587 C  C   . GLU A 1 245 ? -19.798 -37.156 -30.003 1.00 35.89  ? 508  GLU A C   1 
ATOM   1588 O  O   . GLU A 1 245 ? -20.035 -37.121 -31.236 1.00 34.44  ? 508  GLU A O   1 
ATOM   1589 C  CB  . GLU A 1 245 ? -19.180 -34.839 -29.268 1.00 37.65  ? 508  GLU A CB  1 
ATOM   1590 C  CG  . GLU A 1 245 ? -20.268 -34.714 -28.208 1.00 43.25  ? 508  GLU A CG  1 
ATOM   1591 C  CD  . GLU A 1 245 ? -21.711 -34.988 -28.647 1.00 48.51  ? 508  GLU A CD  1 
ATOM   1592 O  OE1 . GLU A 1 245 ? -22.042 -34.745 -29.834 1.00 47.22  ? 508  GLU A OE1 1 
ATOM   1593 O  OE2 . GLU A 1 245 ? -22.525 -35.433 -27.788 1.00 56.00  ? 508  GLU A OE2 1 
ATOM   1594 N  N   . GLY A 1 246 ? -20.373 -38.000 -29.147 1.00 38.22  ? 509  GLY A N   1 
ATOM   1595 C  CA  . GLY A 1 246 ? -21.474 -38.897 -29.532 1.00 41.65  ? 509  GLY A CA  1 
ATOM   1596 C  C   . GLY A 1 246 ? -20.989 -40.157 -30.224 1.00 41.31  ? 509  GLY A C   1 
ATOM   1597 O  O   . GLY A 1 246 ? -21.851 -40.935 -30.622 1.00 41.04  ? 509  GLY A O   1 
ATOM   1598 N  N   . GLU A 1 247 ? -19.678 -40.385 -30.365 1.00 41.26  ? 510  GLU A N   1 
ATOM   1599 C  CA  . GLU A 1 247 ? -19.206 -41.498 -31.226 1.00 45.07  ? 510  GLU A CA  1 
ATOM   1600 C  C   . GLU A 1 247 ? -19.478 -42.822 -30.505 1.00 43.29  ? 510  GLU A C   1 
ATOM   1601 O  O   . GLU A 1 247 ? -19.969 -43.732 -31.201 1.00 56.60  ? 510  GLU A O   1 
ATOM   1602 C  CB  . GLU A 1 247 ? -17.753 -41.369 -31.681 1.00 40.42  ? 510  GLU A CB  1 
ATOM   1603 C  CG  . GLU A 1 247 ? -17.538 -40.190 -32.595 1.00 46.29  ? 510  GLU A CG  1 
ATOM   1604 C  CD  . GLU A 1 247 ? -18.452 -40.075 -33.804 1.00 52.57  ? 510  GLU A CD  1 
ATOM   1605 O  OE1 . GLU A 1 247 ? -18.620 -41.116 -34.463 1.00 49.41  ? 510  GLU A OE1 1 
ATOM   1606 O  OE2 . GLU A 1 247 ? -18.985 -38.906 -34.088 1.00 55.57  ? 510  GLU A OE2 1 
ATOM   1607 N  N   . GLY A 1 248 ? -19.200 -42.962 -29.209 1.00 36.11  ? 511  GLY A N   1 
ATOM   1608 C  CA  . GLY A 1 248 ? -19.375 -44.288 -28.549 1.00 34.74  ? 511  GLY A CA  1 
ATOM   1609 C  C   . GLY A 1 248 ? -18.082 -45.135 -28.572 1.00 38.04  ? 511  GLY A C   1 
ATOM   1610 O  O   . GLY A 1 248 ? -17.275 -45.052 -29.552 1.00 36.47  ? 511  GLY A O   1 
ATOM   1611 N  N   A LEU A 1 249 ? -17.908 -45.970 -27.547 0.25 36.00  ? 512  LEU A N   1 
ATOM   1612 N  N   B LEU A 1 249 ? -17.880 -45.944 -27.524 0.25 36.00  ? 512  LEU A N   1 
ATOM   1613 C  CA  A LEU A 1 249 ? -16.650 -46.691 -27.234 0.25 35.75  ? 512  LEU A CA  1 
ATOM   1614 C  CA  B LEU A 1 249 ? -16.628 -46.699 -27.250 0.25 35.72  ? 512  LEU A CA  1 
ATOM   1615 C  C   A LEU A 1 249 ? -16.380 -47.773 -28.284 0.25 35.40  ? 512  LEU A C   1 
ATOM   1616 C  C   B LEU A 1 249 ? -16.362 -47.718 -28.358 0.25 35.32  ? 512  LEU A C   1 
ATOM   1617 O  O   A LEU A 1 249 ? -15.201 -48.139 -28.468 0.25 37.31  ? 512  LEU A O   1 
ATOM   1618 O  O   B LEU A 1 249 ? -15.178 -48.000 -28.635 0.25 36.79  ? 512  LEU A O   1 
ATOM   1619 C  CB  A LEU A 1 249 ? -16.809 -47.288 -25.836 0.25 36.42  ? 512  LEU A CB  1 
ATOM   1620 C  CB  B LEU A 1 249 ? -16.765 -47.410 -25.901 0.25 36.52  ? 512  LEU A CB  1 
ATOM   1621 C  CG  A LEU A 1 249 ? -15.530 -47.784 -25.176 0.25 35.51  ? 512  LEU A CG  1 
ATOM   1622 C  CG  B LEU A 1 249 ? -15.972 -46.799 -24.751 0.25 35.53  ? 512  LEU A CG  1 
ATOM   1623 C  CD1 A LEU A 1 249 ? -14.458 -46.700 -25.178 0.25 35.14  ? 512  LEU A CD1 1 
ATOM   1624 C  CD1 B LEU A 1 249 ? -16.117 -47.654 -23.505 0.25 35.20  ? 512  LEU A CD1 1 
ATOM   1625 C  CD2 A LEU A 1 249 ? -15.832 -48.253 -23.764 0.25 35.16  ? 512  LEU A CD2 1 
ATOM   1626 C  CD2 B LEU A 1 249 ? -14.504 -46.642 -25.134 0.25 35.25  ? 512  LEU A CD2 1 
ATOM   1627 N  N   . HIS A 1 250 ? -17.434 -48.250 -28.948 0.50 35.11  ? 513  HIS A N   1 
ATOM   1628 C  CA  . HIS A 1 250 ? -17.398 -49.220 -30.077 0.50 34.57  ? 513  HIS A CA  1 
ATOM   1629 C  C   . HIS A 1 250 ? -16.997 -48.540 -31.394 0.50 33.41  ? 513  HIS A C   1 
ATOM   1630 O  O   . HIS A 1 250 ? -16.858 -49.262 -32.398 0.50 33.58  ? 513  HIS A O   1 
ATOM   1631 C  CB  . HIS A 1 250 ? -18.778 -49.873 -30.230 0.50 37.06  ? 513  HIS A CB  1 
ATOM   1632 C  CG  . HIS A 1 250 ? -19.848 -48.871 -30.496 0.50 36.79  ? 513  HIS A CG  1 
ATOM   1633 N  ND1 . HIS A 1 250 ? -20.203 -47.916 -29.565 0.50 36.99  ? 513  HIS A ND1 1 
ATOM   1634 C  CD2 . HIS A 1 250 ? -20.602 -48.640 -31.593 0.50 37.37  ? 513  HIS A CD2 1 
ATOM   1635 C  CE1 . HIS A 1 250 ? -21.143 -47.146 -30.073 0.50 37.58  ? 513  HIS A CE1 1 
ATOM   1636 N  NE2 . HIS A 1 250 ? -21.409 -47.574 -31.314 0.50 37.79  ? 513  HIS A NE2 1 
ATOM   1637 N  N   . LYS A 1 251 ? -16.846 -47.210 -31.407 1.00 34.91  ? 514  LYS A N   1 
ATOM   1638 C  CA  . LYS A 1 251 ? -16.429 -46.455 -32.621 1.00 35.04  ? 514  LYS A CA  1 
ATOM   1639 C  C   . LYS A 1 251 ? -15.003 -45.905 -32.455 1.00 34.77  ? 514  LYS A C   1 
ATOM   1640 O  O   . LYS A 1 251 ? -14.315 -45.800 -33.487 1.00 31.02  ? 514  LYS A O   1 
ATOM   1641 C  CB  . LYS A 1 251 ? -17.473 -45.385 -32.921 1.00 40.11  ? 514  LYS A CB  1 
ATOM   1642 C  CG  . LYS A 1 251 ? -18.908 -45.907 -32.920 1.00 47.93  ? 514  LYS A CG  1 
ATOM   1643 C  CD  . LYS A 1 251 ? -19.568 -45.945 -34.260 1.00 52.38  ? 514  LYS A CD  1 
ATOM   1644 C  CE  . LYS A 1 251 ? -19.969 -44.565 -34.713 1.00 60.09  ? 514  LYS A CE  1 
ATOM   1645 N  NZ  . LYS A 1 251 ? -20.506 -44.590 -36.090 1.00 69.19  ? 514  LYS A NZ  1 
ATOM   1646 N  N   . LEU A 1 252 ? -14.551 -45.609 -31.228 1.00 30.82  ? 515  LEU A N   1 
ATOM   1647 C  CA  . LEU A 1 252 ? -13.273 -44.888 -30.983 1.00 30.57  ? 515  LEU A CA  1 
ATOM   1648 C  C   . LEU A 1 252 ? -12.091 -45.676 -31.560 1.00 31.19  ? 515  LEU A C   1 
ATOM   1649 O  O   . LEU A 1 252 ? -11.200 -45.045 -32.152 1.00 32.13  ? 515  LEU A O   1 
ATOM   1650 C  CB  . LEU A 1 252 ? -13.085 -44.624 -29.488 1.00 29.55  ? 515  LEU A CB  1 
ATOM   1651 C  CG  . LEU A 1 252 ? -14.135 -43.718 -28.858 1.00 30.10  ? 515  LEU A CG  1 
ATOM   1652 C  CD1 . LEU A 1 252 ? -13.792 -43.424 -27.412 1.00 32.20  ? 515  LEU A CD1 1 
ATOM   1653 C  CD2 . LEU A 1 252 ? -14.289 -42.404 -29.622 1.00 28.80  ? 515  LEU A CD2 1 
ATOM   1654 N  N   . GLY A 1 253 ? -12.079 -47.004 -31.413 1.00 29.95  ? 516  GLY A N   1 
ATOM   1655 C  CA  . GLY A 1 253 ? -11.015 -47.854 -31.974 1.00 31.72  ? 516  GLY A CA  1 
ATOM   1656 C  C   . GLY A 1 253 ? -10.939 -47.784 -33.498 1.00 30.46  ? 516  GLY A C   1 
ATOM   1657 O  O   . GLY A 1 253 ? -9.837  -47.700 -34.047 1.00 31.47  ? 516  GLY A O   1 
ATOM   1658 N  N   . TYR A 1 254 ? -12.063 -47.847 -34.180 1.00 29.01  ? 517  TYR A N   1 
ATOM   1659 C  CA  . TYR A 1 254 ? -12.115 -47.737 -35.660 1.00 32.16  ? 517  TYR A CA  1 
ATOM   1660 C  C   . TYR A 1 254 ? -11.575 -46.365 -36.093 1.00 31.12  ? 517  TYR A C   1 
ATOM   1661 O  O   . TYR A 1 254 ? -10.853 -46.248 -37.098 1.00 32.42  ? 517  TYR A O   1 
ATOM   1662 C  CB  . TYR A 1 254 ? -13.552 -47.923 -36.134 1.00 31.62  ? 517  TYR A CB  1 
ATOM   1663 C  CG  . TYR A 1 254 ? -14.026 -49.348 -36.152 1.00 30.86  ? 517  TYR A CG  1 
ATOM   1664 C  CD1 . TYR A 1 254 ? -13.544 -50.247 -37.100 1.00 33.45  ? 517  TYR A CD1 1 
ATOM   1665 C  CD2 . TYR A 1 254 ? -14.954 -49.811 -35.234 1.00 30.34  ? 517  TYR A CD2 1 
ATOM   1666 C  CE1 . TYR A 1 254 ? -13.978 -51.566 -37.149 1.00 28.90  ? 517  TYR A CE1 1 
ATOM   1667 C  CE2 . TYR A 1 254 ? -15.405 -51.125 -35.269 1.00 29.71  ? 517  TYR A CE2 1 
ATOM   1668 C  CZ  . TYR A 1 254 ? -14.938 -51.997 -36.249 1.00 31.45  ? 517  TYR A CZ  1 
ATOM   1669 O  OH  . TYR A 1 254 ? -15.414 -53.288 -36.309 1.00 29.80  ? 517  TYR A OH  1 
ATOM   1670 N  N   . ILE A 1 255 ? -11.918 -45.335 -35.323 0.50 30.73  ? 518  ILE A N   1 
ATOM   1671 C  CA  . ILE A 1 255 ? -11.514 -43.925 -35.581 0.50 32.25  ? 518  ILE A CA  1 
ATOM   1672 C  C   . ILE A 1 255 ? -9.986  -43.801 -35.448 0.50 32.05  ? 518  ILE A C   1 
ATOM   1673 O  O   . ILE A 1 255 ? -9.375  -43.193 -36.351 0.50 32.28  ? 518  ILE A O   1 
ATOM   1674 C  CB  . ILE A 1 255 ? -12.296 -42.970 -34.653 0.50 32.17  ? 518  ILE A CB  1 
ATOM   1675 C  CG1 . ILE A 1 255 ? -13.753 -42.837 -35.115 0.50 32.15  ? 518  ILE A CG1 1 
ATOM   1676 C  CG2 . ILE A 1 255 ? -11.606 -41.618 -34.549 0.50 32.76  ? 518  ILE A CG2 1 
ATOM   1677 C  CD1 . ILE A 1 255 ? -14.650 -42.081 -34.152 0.50 32.07  ? 518  ILE A CD1 1 
ATOM   1678 N  N   . LEU A 1 256 ? -9.392  -44.381 -34.397 1.00 31.29  ? 519  LEU A N   1 
ATOM   1679 C  CA  . LEU A 1 256 ? -7.919  -44.370 -34.199 1.00 33.58  ? 519  LEU A CA  1 
ATOM   1680 C  C   . LEU A 1 256 ? -7.256  -45.154 -35.313 1.00 32.98  ? 519  LEU A C   1 
ATOM   1681 O  O   . LEU A 1 256 ? -6.147  -44.759 -35.714 1.00 38.98  ? 519  LEU A O   1 
ATOM   1682 C  CB  . LEU A 1 256 ? -7.496  -45.021 -32.885 1.00 35.44  ? 519  LEU A CB  1 
ATOM   1683 C  CG  . LEU A 1 256 ? -7.767  -44.238 -31.610 1.00 37.01  ? 519  LEU A CG  1 
ATOM   1684 C  CD1 . LEU A 1 256 ? -7.050  -44.920 -30.456 1.00 35.24  ? 519  LEU A CD1 1 
ATOM   1685 C  CD2 . LEU A 1 256 ? -7.332  -42.793 -31.748 1.00 39.24  ? 519  LEU A CD2 1 
ATOM   1686 N  N   . ARG A 1 257 ? -7.836  -46.292 -35.694 1.00 33.88  ? 520  ARG A N   1 
ATOM   1687 C  CA  . ARG A 1 257 ? -7.307  -47.082 -36.833 1.00 33.49  ? 520  ARG A CA  1 
ATOM   1688 C  C   . ARG A 1 257 ? -7.380  -46.234 -38.113 1.00 35.88  ? 520  ARG A C   1 
ATOM   1689 O  O   . ARG A 1 257 ? -6.400  -46.284 -38.882 1.00 35.59  ? 520  ARG A O   1 
ATOM   1690 C  CB  . ARG A 1 257 ? -8.018  -48.414 -37.014 1.00 33.72  ? 520  ARG A CB  1 
ATOM   1691 C  CG  . ARG A 1 257 ? -7.356  -49.294 -38.073 1.00 33.24  ? 520  ARG A CG  1 
ATOM   1692 C  CD  . ARG A 1 257 ? -8.107  -50.592 -38.263 1.00 33.34  ? 520  ARG A CD  1 
ATOM   1693 N  NE  . ARG A 1 257 ? -9.402  -50.388 -38.916 1.00 36.72  ? 520  ARG A NE  1 
ATOM   1694 C  CZ  . ARG A 1 257 ? -10.227 -51.363 -39.285 1.00 33.46  ? 520  ARG A CZ  1 
ATOM   1695 N  NH1 . ARG A 1 257 ? -9.927  -52.612 -39.020 1.00 30.90  ? 520  ARG A NH1 1 
ATOM   1696 N  NH2 . ARG A 1 257 ? -11.361 -51.082 -39.890 1.00 37.43  ? 520  ARG A NH2 1 
ATOM   1697 N  N   . ASP A 1 258 ? -8.450  -45.456 -38.322 1.00 33.29  ? 521  ASP A N   1 
ATOM   1698 C  CA  . ASP A 1 258 ? -8.545  -44.571 -39.529 1.00 35.41  ? 521  ASP A CA  1 
ATOM   1699 C  C   . ASP A 1 258 ? -7.430  -43.512 -39.502 1.00 31.43  ? 521  ASP A C   1 
ATOM   1700 O  O   . ASP A 1 258 ? -6.761  -43.360 -40.486 1.00 32.17  ? 521  ASP A O   1 
ATOM   1701 C  CB  . ASP A 1 258 ? -9.926  -43.941 -39.713 1.00 33.15  ? 521  ASP A CB  1 
ATOM   1702 C  CG  . ASP A 1 258 ? -10.939 -44.835 -40.436 1.00 38.50  ? 521  ASP A CG  1 
ATOM   1703 O  OD1 . ASP A 1 258 ? -10.535 -45.842 -41.073 1.00 37.68  ? 521  ASP A OD1 1 
ATOM   1704 O  OD2 . ASP A 1 258 ? -12.144 -44.518 -40.350 1.00 39.94  ? 521  ASP A OD2 1 
ATOM   1705 N  N   . VAL A 1 259 ? -7.221  -42.823 -38.390 1.00 32.24  ? 522  VAL A N   1 
ATOM   1706 C  CA  . VAL A 1 259 ? -6.058  -41.922 -38.230 1.00 32.79  ? 522  VAL A CA  1 
ATOM   1707 C  C   . VAL A 1 259 ? -4.761  -42.672 -38.579 1.00 34.08  ? 522  VAL A C   1 
ATOM   1708 O  O   . VAL A 1 259 ? -3.979  -42.114 -39.299 1.00 39.96  ? 522  VAL A O   1 
ATOM   1709 C  CB  . VAL A 1 259 ? -5.989  -41.375 -36.803 1.00 33.00  ? 522  VAL A CB  1 
ATOM   1710 C  CG1 . VAL A 1 259 ? -4.668  -40.657 -36.605 1.00 31.44  ? 522  VAL A CG1 1 
ATOM   1711 C  CG2 . VAL A 1 259 ? -7.184  -40.470 -36.490 1.00 31.70  ? 522  VAL A CG2 1 
ATOM   1712 N  N   . SER A 1 260 ? -4.533  -43.890 -38.091 1.00 34.24  ? 523  SER A N   1 
ATOM   1713 C  CA  . SER A 1 260 ? -3.285  -44.661 -38.354 1.00 38.33  ? 523  SER A CA  1 
ATOM   1714 C  C   . SER A 1 260 ? -3.042  -44.846 -39.866 1.00 36.68  ? 523  SER A C   1 
ATOM   1715 O  O   . SER A 1 260 ? -1.902  -44.980 -40.249 1.00 38.10  ? 523  SER A O   1 
ATOM   1716 C  CB  . SER A 1 260 ? -3.271  -46.001 -37.647 1.00 38.29  ? 523  SER A CB  1 
ATOM   1717 O  OG  . SER A 1 260 ? -3.918  -46.997 -38.433 1.00 34.01  ? 523  SER A OG  1 
ATOM   1718 N  N   . LYS A 1 261 ? -4.061  -44.793 -40.701 1.00 37.90  ? 524  LYS A N   1 
ATOM   1719 C  CA  . LYS A 1 261 ? -3.965  -45.122 -42.148 1.00 42.45  ? 524  LYS A CA  1 
ATOM   1720 C  C   . LYS A 1 261 ? -3.356  -43.961 -42.936 1.00 41.43  ? 524  LYS A C   1 
ATOM   1721 O  O   . LYS A 1 261 ? -2.999  -44.173 -44.138 1.00 43.86  ? 524  LYS A O   1 
ATOM   1722 C  CB  . LYS A 1 261 ? -5.356  -45.375 -42.727 1.00 44.04  ? 524  LYS A CB  1 
ATOM   1723 C  CG  . LYS A 1 261 ? -5.903  -46.759 -42.465 1.00 52.19  ? 524  LYS A CG  1 
ATOM   1724 C  CD  . LYS A 1 261 ? -7.361  -46.747 -42.767 1.00 60.03  ? 524  LYS A CD  1 
ATOM   1725 C  CE  . LYS A 1 261 ? -8.011  -48.100 -42.828 1.00 65.98  ? 524  LYS A CE  1 
ATOM   1726 N  NZ  . LYS A 1 261 ? -9.467  -47.895 -43.045 1.00 78.18  ? 524  LYS A NZ  1 
ATOM   1727 N  N   . LYS A 1 262 ? -3.330  -42.782 -42.316 1.00 40.39  ? 525  LYS A N   1 
ATOM   1728 C  CA  . LYS A 1 262 ? -2.740  -41.537 -42.875 1.00 45.37  ? 525  LYS A CA  1 
ATOM   1729 C  C   . LYS A 1 262 ? -1.216  -41.661 -42.936 1.00 45.21  ? 525  LYS A C   1 
ATOM   1730 O  O   . LYS A 1 262 ? -0.613  -42.223 -42.022 1.00 43.70  ? 525  LYS A O   1 
ATOM   1731 C  CB  . LYS A 1 262 ? -3.131  -40.326 -42.023 1.00 44.91  ? 525  LYS A CB  1 
ATOM   1732 C  CG  . LYS A 1 262 ? -4.631  -40.067 -41.980 1.00 45.78  ? 525  LYS A CG  1 
ATOM   1733 C  CD  . LYS A 1 262 ? -4.991  -38.626 -42.170 1.00 46.72  ? 525  LYS A CD  1 
ATOM   1734 C  CE  . LYS A 1 262 ? -6.376  -38.410 -42.719 1.00 52.71  ? 525  LYS A CE  1 
ATOM   1735 N  NZ  . LYS A 1 262 ? -6.433  -37.155 -43.503 1.00 62.58  ? 525  LYS A NZ  1 
ATOM   1736 N  N   . GLU A 1 263 ? -0.615  -41.131 -43.988 1.00 48.09  ? 526  GLU A N   1 
ATOM   1737 C  CA  . GLU A 1 263 ? 0.854   -40.993 -44.060 1.00 46.67  ? 526  GLU A CA  1 
ATOM   1738 C  C   . GLU A 1 263 ? 1.280   -40.055 -42.932 1.00 42.53  ? 526  GLU A C   1 
ATOM   1739 O  O   . GLU A 1 263 ? 0.602   -39.037 -42.716 1.00 44.00  ? 526  GLU A O   1 
ATOM   1740 C  CB  . GLU A 1 263 ? 1.237   -40.481 -45.445 1.00 55.47  ? 526  GLU A CB  1 
ATOM   1741 C  CG  . GLU A 1 263 ? 0.971   -41.498 -46.549 1.00 61.70  ? 526  GLU A CG  1 
ATOM   1742 C  CD  . GLU A 1 263 ? 1.874   -42.720 -46.495 1.00 67.61  ? 526  GLU A CD  1 
ATOM   1743 O  OE1 . GLU A 1 263 ? 3.045   -42.566 -46.078 1.00 72.25  ? 526  GLU A OE1 1 
ATOM   1744 O  OE2 . GLU A 1 263 ? 1.409   -43.817 -46.859 1.00 68.71  ? 526  GLU A OE2 1 
ATOM   1745 N  N   . GLY A 1 264 ? 2.341   -40.384 -42.217 1.00 36.02  ? 527  GLY A N   1 
ATOM   1746 C  CA  . GLY A 1 264 ? 2.900   -39.462 -41.214 1.00 38.18  ? 527  GLY A CA  1 
ATOM   1747 C  C   . GLY A 1 264 ? 3.844   -40.160 -40.260 1.00 35.85  ? 527  GLY A C   1 
ATOM   1748 O  O   . GLY A 1 264 ? 4.333   -41.209 -40.594 1.00 39.35  ? 527  GLY A O   1 
ATOM   1749 N  N   . GLY A 1 265 ? 4.078   -39.583 -39.088 1.00 41.09  ? 528  GLY A N   1 
ATOM   1750 C  CA  . GLY A 1 265 ? 5.012   -40.161 -38.106 1.00 39.44  ? 528  GLY A CA  1 
ATOM   1751 C  C   . GLY A 1 265 ? 4.285   -40.956 -37.041 1.00 40.84  ? 528  GLY A C   1 
ATOM   1752 O  O   . GLY A 1 265 ? 3.225   -41.542 -37.340 1.00 42.20  ? 528  GLY A O   1 
ATOM   1753 N  N   . ALA A 1 266 ? 4.844   -40.990 -35.837 1.00 37.44  ? 529  ALA A N   1 
ATOM   1754 C  CA  . ALA A 1 266 ? 4.320   -41.780 -34.707 1.00 36.22  ? 529  ALA A CA  1 
ATOM   1755 C  C   . ALA A 1 266 ? 2.943   -41.212 -34.369 1.00 34.12  ? 529  ALA A C   1 
ATOM   1756 O  O   . ALA A 1 266 ? 2.621   -40.141 -34.884 1.00 34.50  ? 529  ALA A O   1 
ATOM   1757 C  CB  . ALA A 1 266 ? 5.285   -41.702 -33.541 1.00 33.76  ? 529  ALA A CB  1 
ATOM   1758 N  N   . MET A 1 267 ? 2.167   -41.903 -33.548 1.00 32.96  ? 530  MET A N   1 
ATOM   1759 C  CA  . MET A 1 267 ? 0.926   -41.342 -32.961 1.00 35.16  ? 530  MET A CA  1 
ATOM   1760 C  C   . MET A 1 267 ? 1.312   -40.759 -31.585 1.00 29.63  ? 530  MET A C   1 
ATOM   1761 O  O   . MET A 1 267 ? 2.007   -41.429 -30.820 1.00 38.00  ? 530  MET A O   1 
ATOM   1762 C  CB  . MET A 1 267 ? -0.175  -42.416 -32.892 1.00 36.47  ? 530  MET A CB  1 
ATOM   1763 C  CG  . MET A 1 267 ? -0.676  -42.835 -34.285 1.00 42.45  ? 530  MET A CG  1 
ATOM   1764 S  SD  . MET A 1 267 ? -2.132  -43.948 -34.352 1.00 43.32  ? 530  MET A SD  1 
ATOM   1765 C  CE  . MET A 1 267 ? -3.510  -42.833 -34.168 1.00 53.93  ? 530  MET A CE  1 
ATOM   1766 N  N   . TYR A 1 268 ? 0.941   -39.531 -31.286 1.00 28.56  ? 531  TYR A N   1 
ATOM   1767 C  CA  . TYR A 1 268 ? 1.319   -38.861 -30.014 1.00 29.80  ? 531  TYR A CA  1 
ATOM   1768 C  C   . TYR A 1 268 ? 0.061   -38.709 -29.188 1.00 30.05  ? 531  TYR A C   1 
ATOM   1769 O  O   . TYR A 1 268 ? -1.013  -38.324 -29.721 1.00 33.40  ? 531  TYR A O   1 
ATOM   1770 C  CB  . TYR A 1 268 ? 2.056   -37.541 -30.229 1.00 29.88  ? 531  TYR A CB  1 
ATOM   1771 C  CG  . TYR A 1 268 ? 3.372   -37.705 -30.950 1.00 32.86  ? 531  TYR A CG  1 
ATOM   1772 C  CD1 . TYR A 1 268 ? 3.406   -37.874 -32.324 1.00 33.50  ? 531  TYR A CD1 1 
ATOM   1773 C  CD2 . TYR A 1 268 ? 4.573   -37.789 -30.261 1.00 32.46  ? 531  TYR A CD2 1 
ATOM   1774 C  CE1 . TYR A 1 268 ? 4.605   -38.063 -32.986 1.00 35.74  ? 531  TYR A CE1 1 
ATOM   1775 C  CE2 . TYR A 1 268 ? 5.774   -37.992 -30.913 1.00 31.31  ? 531  TYR A CE2 1 
ATOM   1776 C  CZ  . TYR A 1 268 ? 5.798   -38.108 -32.288 1.00 33.46  ? 531  TYR A CZ  1 
ATOM   1777 O  OH  . TYR A 1 268 ? 6.976   -38.338 -32.962 1.00 33.15  ? 531  TYR A OH  1 
ATOM   1778 N  N   . ALA A 1 269 ? 0.182   -39.079 -27.925 1.00 29.95  ? 532  ALA A N   1 
ATOM   1779 C  CA  . ALA A 1 269 ? -0.929  -38.976 -26.973 1.00 31.65  ? 532  ALA A CA  1 
ATOM   1780 C  C   . ALA A 1 269 ? -0.405  -38.386 -25.682 1.00 30.02  ? 532  ALA A C   1 
ATOM   1781 O  O   . ALA A 1 269 ? -0.397  -39.106 -24.685 1.00 37.18  ? 532  ALA A O   1 
ATOM   1782 C  CB  . ALA A 1 269 ? -1.592  -40.313 -26.792 1.00 30.32  ? 532  ALA A CB  1 
ATOM   1783 N  N   . ASP A 1 270 ? -0.063  -37.103 -25.702 1.00 28.38  ? 533  ASP A N   1 
ATOM   1784 C  CA  . ASP A 1 270 ? 0.443   -36.378 -24.509 1.00 31.86  ? 533  ASP A CA  1 
ATOM   1785 C  C   . ASP A 1 270 ? -0.730  -35.848 -23.705 1.00 35.59  ? 533  ASP A C   1 
ATOM   1786 O  O   . ASP A 1 270 ? -1.505  -35.079 -24.224 1.00 36.92  ? 533  ASP A O   1 
ATOM   1787 C  CB  . ASP A 1 270 ? 1.372   -35.234 -24.919 1.00 32.50  ? 533  ASP A CB  1 
ATOM   1788 C  CG  . ASP A 1 270 ? 2.652   -35.724 -25.586 1.00 35.60  ? 533  ASP A CG  1 
ATOM   1789 O  OD1 . ASP A 1 270 ? 2.959   -36.933 -25.430 1.00 38.58  ? 533  ASP A OD1 1 
ATOM   1790 O  OD2 . ASP A 1 270 ? 3.327   -34.924 -26.268 1.00 30.98  ? 533  ASP A OD2 1 
ATOM   1791 N  N   . ASP A 1 271 ? -0.820  -36.268 -22.440 0.26 37.90  ? 534  ASP A N   1 
ATOM   1792 C  CA  . ASP A 1 271 ? -1.777  -35.742 -21.429 0.26 38.89  ? 534  ASP A CA  1 
ATOM   1793 C  C   . ASP A 1 271 ? -1.238  -34.425 -20.861 0.26 39.45  ? 534  ASP A C   1 
ATOM   1794 O  O   . ASP A 1 271 ? -0.010  -34.326 -20.662 0.26 40.13  ? 534  ASP A O   1 
ATOM   1795 C  CB  . ASP A 1 271 ? -1.999  -36.744 -20.294 0.26 40.52  ? 534  ASP A CB  1 
ATOM   1796 C  CG  . ASP A 1 271 ? -2.911  -37.895 -20.672 0.26 41.77  ? 534  ASP A CG  1 
ATOM   1797 O  OD1 . ASP A 1 271 ? -4.005  -37.617 -21.195 0.26 42.95  ? 534  ASP A OD1 1 
ATOM   1798 O  OD2 . ASP A 1 271 ? -2.518  -39.056 -20.441 0.26 42.65  ? 534  ASP A OD2 1 
ATOM   1799 N  N   . THR A 1 272 ? -2.128  -33.463 -20.599 0.26 39.36  ? 535  THR A N   1 
ATOM   1800 C  CA  . THR A 1 272 ? -1.810  -32.154 -19.971 0.26 39.74  ? 535  THR A CA  1 
ATOM   1801 C  C   . THR A 1 272 ? -2.041  -32.260 -18.462 0.26 39.47  ? 535  THR A C   1 
ATOM   1802 O  O   . THR A 1 272 ? -3.137  -32.693 -18.064 0.26 41.01  ? 535  THR A O   1 
ATOM   1803 C  CB  . THR A 1 272 ? -2.645  -31.022 -20.578 0.26 39.57  ? 535  THR A CB  1 
ATOM   1804 O  OG1 . THR A 1 272 ? -2.417  -31.021 -21.987 0.26 40.68  ? 535  THR A OG1 1 
ATOM   1805 C  CG2 . THR A 1 272 ? -2.306  -29.664 -20.002 0.26 39.93  ? 535  THR A CG2 1 
ATOM   1806 N  N   . ALA A 1 273 ? -1.050  -31.855 -17.665 0.26 40.30  ? 536  ALA A N   1 
ATOM   1807 C  CA  . ALA A 1 273 ? -1.071  -31.906 -16.185 0.26 41.66  ? 536  ALA A CA  1 
ATOM   1808 C  C   . ALA A 1 273 ? -2.055  -30.860 -15.641 0.26 41.35  ? 536  ALA A C   1 
ATOM   1809 O  O   . ALA A 1 273 ? -1.635  -29.708 -15.421 0.26 42.68  ? 536  ALA A O   1 
ATOM   1810 C  CB  . ALA A 1 273 ? 0.328   -31.703 -15.650 0.26 41.76  ? 536  ALA A CB  1 
ATOM   1811 N  N   . GLY A 1 274 ? -3.315  -31.259 -15.435 0.26 42.22  ? 537  GLY A N   1 
ATOM   1812 C  CA  . GLY A 1 274 ? -4.392  -30.411 -14.884 0.26 42.84  ? 537  GLY A CA  1 
ATOM   1813 C  C   . GLY A 1 274 ? -4.860  -29.367 -15.885 0.26 42.76  ? 537  GLY A C   1 
ATOM   1814 O  O   . GLY A 1 274 ? -4.702  -28.164 -15.599 0.26 42.92  ? 537  GLY A O   1 
ATOM   1815 N  N   . TRP A 1 275 ? -5.438  -29.815 -17.004 0.26 42.36  ? 538  TRP A N   1 
ATOM   1816 C  CA  . TRP A 1 275 ? -5.876  -28.976 -18.154 0.26 41.67  ? 538  TRP A CA  1 
ATOM   1817 C  C   . TRP A 1 275 ? -6.734  -27.794 -17.681 0.26 41.38  ? 538  TRP A C   1 
ATOM   1818 O  O   . TRP A 1 275 ? -6.482  -26.670 -18.154 0.26 41.57  ? 538  TRP A O   1 
ATOM   1819 C  CB  . TRP A 1 275 ? -6.630  -29.823 -19.185 0.26 40.42  ? 538  TRP A CB  1 
ATOM   1820 C  CG  . TRP A 1 275 ? -7.218  -29.017 -20.301 0.26 40.10  ? 538  TRP A CG  1 
ATOM   1821 C  CD1 . TRP A 1 275 ? -8.438  -28.406 -20.317 0.26 40.29  ? 538  TRP A CD1 1 
ATOM   1822 C  CD2 . TRP A 1 275 ? -6.607  -28.722 -21.569 0.26 39.99  ? 538  TRP A CD2 1 
ATOM   1823 N  NE1 . TRP A 1 275 ? -8.628  -27.757 -21.506 0.26 40.79  ? 538  TRP A NE1 1 
ATOM   1824 C  CE2 . TRP A 1 275 ? -7.523  -27.931 -22.294 0.26 40.13  ? 538  TRP A CE2 1 
ATOM   1825 C  CE3 . TRP A 1 275 ? -5.385  -29.051 -22.166 0.26 39.93  ? 538  TRP A CE3 1 
ATOM   1826 C  CZ2 . TRP A 1 275 ? -7.254  -27.466 -23.580 0.26 40.10  ? 538  TRP A CZ2 1 
ATOM   1827 C  CZ3 . TRP A 1 275 ? -5.117  -28.588 -23.436 0.26 40.44  ? 538  TRP A CZ3 1 
ATOM   1828 C  CH2 . TRP A 1 275 ? -6.042  -27.810 -24.133 0.26 39.96  ? 538  TRP A CH2 1 
ATOM   1829 N  N   . ASP A 1 276 ? -7.712  -28.041 -16.804 0.26 41.63  ? 539  ASP A N   1 
ATOM   1830 C  CA  . ASP A 1 276 ? -8.720  -27.035 -16.361 0.26 42.13  ? 539  ASP A CA  1 
ATOM   1831 C  C   . ASP A 1 276 ? -8.033  -25.895 -15.592 0.26 43.17  ? 539  ASP A C   1 
ATOM   1832 O  O   . ASP A 1 276 ? -8.570  -24.773 -15.628 0.26 43.44  ? 539  ASP A O   1 
ATOM   1833 C  CB  . ASP A 1 276 ? -9.842  -27.677 -15.539 0.26 40.96  ? 539  ASP A CB  1 
ATOM   1834 C  CG  . ASP A 1 276 ? -10.883 -28.409 -16.375 0.26 41.25  ? 539  ASP A CG  1 
ATOM   1835 O  OD1 . ASP A 1 276 ? -10.522 -28.914 -17.458 0.26 41.36  ? 539  ASP A OD1 1 
ATOM   1836 O  OD2 . ASP A 1 276 ? -12.053 -28.465 -15.940 0.26 39.79  ? 539  ASP A OD2 1 
ATOM   1837 N  N   . THR A 1 277 ? -6.898  -26.162 -14.930 1.00 43.92  ? 540  THR A N   1 
ATOM   1838 C  CA  . THR A 1 277 ? -6.135  -25.130 -14.164 1.00 43.50  ? 540  THR A CA  1 
ATOM   1839 C  C   . THR A 1 277 ? -5.195  -24.333 -15.069 1.00 42.89  ? 540  THR A C   1 
ATOM   1840 O  O   . THR A 1 277 ? -4.672  -23.329 -14.577 1.00 47.82  ? 540  THR A O   1 
ATOM   1841 C  CB  . THR A 1 277 ? -5.373  -25.739 -12.982 1.00 44.67  ? 540  THR A CB  1 
ATOM   1842 O  OG1 . THR A 1 277 ? -4.379  -26.635 -13.456 1.00 49.63  ? 540  THR A OG1 1 
ATOM   1843 C  CG2 . THR A 1 277 ? -6.289  -26.501 -12.054 1.00 50.51  ? 540  THR A CG2 1 
ATOM   1844 N  N   . ARG A 1 278 ? -4.982  -24.756 -16.317 1.00 41.57  ? 541  ARG A N   1 
ATOM   1845 C  CA  . ARG A 1 278 ? -4.054  -24.121 -17.289 1.00 39.63  ? 541  ARG A CA  1 
ATOM   1846 C  C   . ARG A 1 278 ? -4.832  -23.351 -18.349 1.00 39.62  ? 541  ARG A C   1 
ATOM   1847 O  O   . ARG A 1 278 ? -4.214  -22.965 -19.352 1.00 42.43  ? 541  ARG A O   1 
ATOM   1848 C  CB  . ARG A 1 278 ? -3.258  -25.177 -18.060 1.00 44.45  ? 541  ARG A CB  1 
ATOM   1849 C  CG  . ARG A 1 278 ? -2.743  -26.309 -17.192 1.00 52.16  ? 541  ARG A CG  1 
ATOM   1850 C  CD  . ARG A 1 278 ? -1.312  -26.095 -16.788 1.00 57.13  ? 541  ARG A CD  1 
ATOM   1851 N  NE  . ARG A 1 278 ? -0.843  -27.066 -15.811 1.00 64.01  ? 541  ARG A NE  1 
ATOM   1852 C  CZ  . ARG A 1 278 ? 0.341   -26.989 -15.211 1.00 61.13  ? 541  ARG A CZ  1 
ATOM   1853 N  NH1 . ARG A 1 278 ? 1.170   -26.004 -15.525 1.00 55.68  ? 541  ARG A NH1 1 
ATOM   1854 N  NH2 . ARG A 1 278 ? 0.677   -27.877 -14.290 1.00 56.96  ? 541  ARG A NH2 1 
ATOM   1855 N  N   . ILE A 1 279 ? -6.155  -23.260 -18.220 1.00 41.09  ? 542  ILE A N   1 
ATOM   1856 C  CA  . ILE A 1 279 ? -6.981  -22.439 -19.150 1.00 41.02  ? 542  ILE A CA  1 
ATOM   1857 C  C   . ILE A 1 279 ? -6.736  -20.964 -18.796 1.00 40.72  ? 542  ILE A C   1 
ATOM   1858 O  O   . ILE A 1 279 ? -7.015  -20.532 -17.647 1.00 39.38  ? 542  ILE A O   1 
ATOM   1859 C  CB  . ILE A 1 279 ? -8.460  -22.876 -19.083 1.00 45.83  ? 542  ILE A CB  1 
ATOM   1860 C  CG1 . ILE A 1 279 ? -8.653  -24.215 -19.793 1.00 46.42  ? 542  ILE A CG1 1 
ATOM   1861 C  CG2 . ILE A 1 279 ? -9.388  -21.823 -19.663 1.00 45.17  ? 542  ILE A CG2 1 
ATOM   1862 C  CD1 . ILE A 1 279 ? -8.478  -24.135 -21.301 1.00 45.24  ? 542  ILE A CD1 1 
ATOM   1863 N  N   . THR A 1 280 ? -6.154  -20.234 -19.738 1.00 41.76  ? 543  THR A N   1 
ATOM   1864 C  CA  . THR A 1 280 ? -5.710  -18.833 -19.573 1.00 43.38  ? 543  THR A CA  1 
ATOM   1865 C  C   . THR A 1 280 ? -6.906  -17.928 -19.842 1.00 47.04  ? 543  THR A C   1 
ATOM   1866 O  O   . THR A 1 280 ? -7.916  -18.428 -20.358 1.00 45.96  ? 543  THR A O   1 
ATOM   1867 C  CB  . THR A 1 280 ? -4.544  -18.523 -20.507 1.00 39.01  ? 543  THR A CB  1 
ATOM   1868 O  OG1 . THR A 1 280 ? -5.027  -18.645 -21.835 1.00 38.03  ? 543  THR A OG1 1 
ATOM   1869 C  CG2 . THR A 1 280 ? -3.394  -19.482 -20.341 1.00 42.07  ? 543  THR A CG2 1 
ATOM   1870 N  N   . LEU A 1 281 ? -6.809  -16.658 -19.460 1.00 55.55  ? 544  LEU A N   1 
ATOM   1871 C  CA  . LEU A 1 281 ? -7.829  -15.642 -19.825 1.00 57.51  ? 544  LEU A CA  1 
ATOM   1872 C  C   . LEU A 1 281 ? -7.840  -15.520 -21.352 1.00 48.60  ? 544  LEU A C   1 
ATOM   1873 O  O   . LEU A 1 281 ? -8.900  -15.301 -21.894 1.00 45.25  ? 544  LEU A O   1 
ATOM   1874 C  CB  . LEU A 1 281 ? -7.505  -14.311 -19.139 1.00 65.91  ? 544  LEU A CB  1 
ATOM   1875 C  CG  . LEU A 1 281 ? -8.489  -13.170 -19.397 1.00 74.20  ? 544  LEU A CG  1 
ATOM   1876 C  CD1 . LEU A 1 281 ? -9.943  -13.623 -19.281 1.00 73.68  ? 544  LEU A CD1 1 
ATOM   1877 C  CD2 . LEU A 1 281 ? -8.224  -12.022 -18.440 1.00 76.13  ? 544  LEU A CD2 1 
ATOM   1878 N  N   . GLU A 1 282 ? -6.706  -15.727 -22.019 1.00 45.01  ? 545  GLU A N   1 
ATOM   1879 C  CA  . GLU A 1 282 ? -6.600  -15.628 -23.500 1.00 47.37  ? 545  GLU A CA  1 
ATOM   1880 C  C   . GLU A 1 282 ? -7.381  -16.777 -24.163 1.00 45.55  ? 545  GLU A C   1 
ATOM   1881 O  O   . GLU A 1 282 ? -8.037  -16.579 -25.215 1.00 42.99  ? 545  GLU A O   1 
ATOM   1882 C  CB  . GLU A 1 282 ? -5.128  -15.608 -23.889 1.00 51.91  ? 545  GLU A CB  1 
ATOM   1883 C  CG  . GLU A 1 282 ? -4.907  -14.913 -25.211 1.00 64.66  ? 545  GLU A CG  1 
ATOM   1884 C  CD  . GLU A 1 282 ? -5.130  -13.410 -25.172 1.00 71.77  ? 545  GLU A CD  1 
ATOM   1885 O  OE1 . GLU A 1 282 ? -4.977  -12.814 -24.066 1.00 67.38  ? 545  GLU A OE1 1 
ATOM   1886 O  OE2 . GLU A 1 282 ? -5.476  -12.848 -26.241 1.00 77.25  ? 545  GLU A OE2 1 
ATOM   1887 N  N   . ASP A 1 283 ? -7.347  -17.948 -23.545 1.00 42.12  ? 546  ASP A N   1 
ATOM   1888 C  CA  . ASP A 1 283 ? -8.200  -19.107 -23.919 1.00 43.14  ? 546  ASP A CA  1 
ATOM   1889 C  C   . ASP A 1 283 ? -9.696  -18.742 -23.751 1.00 42.17  ? 546  ASP A C   1 
ATOM   1890 O  O   . ASP A 1 283 ? -10.497 -19.005 -24.691 1.00 41.95  ? 546  ASP A O   1 
ATOM   1891 C  CB  . ASP A 1 283 ? -7.835  -20.327 -23.056 1.00 42.07  ? 546  ASP A CB  1 
ATOM   1892 C  CG  . ASP A 1 283 ? -6.482  -20.947 -23.348 1.00 38.80  ? 546  ASP A CG  1 
ATOM   1893 O  OD1 . ASP A 1 283 ? -6.001  -20.844 -24.498 1.00 42.29  ? 546  ASP A OD1 1 
ATOM   1894 O  OD2 . ASP A 1 283 ? -5.935  -21.550 -22.429 1.00 38.72  ? 546  ASP A OD2 1 
ATOM   1895 N  N   . LEU A 1 284 ? -10.093 -18.215 -22.587 1.00 37.90  ? 547  LEU A N   1 
ATOM   1896 C  CA  . LEU A 1 284 ? -11.507 -17.826 -22.304 1.00 38.47  ? 547  LEU A CA  1 
ATOM   1897 C  C   . LEU A 1 284 ? -12.002 -16.795 -23.351 1.00 39.22  ? 547  LEU A C   1 
ATOM   1898 O  O   . LEU A 1 284 ? -13.116 -16.952 -23.838 1.00 43.66  ? 547  LEU A O   1 
ATOM   1899 C  CB  . LEU A 1 284 ? -11.601 -17.318 -20.864 1.00 35.42  ? 547  LEU A CB  1 
ATOM   1900 C  CG  . LEU A 1 284 ? -11.411 -18.368 -19.766 1.00 39.02  ? 547  LEU A CG  1 
ATOM   1901 C  CD1 . LEU A 1 284 ? -11.405 -17.751 -18.366 1.00 41.38  ? 547  LEU A CD1 1 
ATOM   1902 C  CD2 . LEU A 1 284 ? -12.497 -19.439 -19.795 1.00 42.00  ? 547  LEU A CD2 1 
ATOM   1903 N  N   . LYS A 1 285 ? -11.154 -15.854 -23.785 1.00 43.68  ? 548  LYS A N   1 
ATOM   1904 C  CA  . LYS A 1 285 ? -11.447 -14.838 -24.836 1.00 45.20  ? 548  LYS A CA  1 
ATOM   1905 C  C   . LYS A 1 285 ? -11.533 -15.464 -26.232 1.00 43.43  ? 548  LYS A C   1 
ATOM   1906 O  O   . LYS A 1 285 ? -12.350 -14.999 -27.023 1.00 46.62  ? 548  LYS A O   1 
ATOM   1907 C  CB  . LYS A 1 285 ? -10.394 -13.721 -24.836 1.00 47.73  ? 548  LYS A CB  1 
ATOM   1908 C  CG  . LYS A 1 285 ? -10.471 -12.789 -23.634 1.00 50.54  ? 548  LYS A CG  1 
ATOM   1909 C  CD  . LYS A 1 285 ? -9.628  -11.543 -23.793 1.00 65.25  ? 548  LYS A CD  1 
ATOM   1910 C  CE  . LYS A 1 285 ? -9.940  -10.465 -22.768 1.00 74.81  ? 548  LYS A CE  1 
ATOM   1911 N  NZ  . LYS A 1 285 ? -9.373  -9.147  -23.162 1.00 79.91  ? 548  LYS A NZ  1 
ATOM   1912 N  N   . ASN A 1 286 ? -10.715 -16.454 -26.561 1.00 41.11  ? 549  ASN A N   1 
ATOM   1913 C  CA  . ASN A 1 286 ? -10.792 -17.107 -27.891 1.00 41.07  ? 549  ASN A CA  1 
ATOM   1914 C  C   . ASN A 1 286 ? -12.065 -17.964 -28.001 1.00 38.79  ? 549  ASN A C   1 
ATOM   1915 O  O   . ASN A 1 286 ? -12.671 -17.996 -29.096 1.00 37.53  ? 549  ASN A O   1 
ATOM   1916 C  CB  . ASN A 1 286 ? -9.498  -17.869 -28.146 1.00 47.56  ? 549  ASN A CB  1 
ATOM   1917 C  CG  . ASN A 1 286 ? -8.339  -16.923 -28.383 1.00 46.89  ? 549  ASN A CG  1 
ATOM   1918 O  OD1 . ASN A 1 286 ? -8.505  -15.887 -29.006 1.00 42.56  ? 549  ASN A OD1 1 
ATOM   1919 N  ND2 . ASN A 1 286 ? -7.157  -17.286 -27.932 1.00 49.07  ? 549  ASN A ND2 1 
ATOM   1920 N  N   . GLU A 1 287 ? -12.470 -18.611 -26.906 1.00 38.06  ? 550  GLU A N   1 
ATOM   1921 C  CA  . GLU A 1 287 ? -13.732 -19.401 -26.782 1.00 39.50  ? 550  GLU A CA  1 
ATOM   1922 C  C   . GLU A 1 287 ? -14.967 -18.485 -26.975 1.00 37.00  ? 550  GLU A C   1 
ATOM   1923 O  O   . GLU A 1 287 ? -15.906 -18.889 -27.669 1.00 39.80  ? 550  GLU A O   1 
ATOM   1924 C  CB  . GLU A 1 287 ? -13.747 -20.154 -25.440 1.00 36.32  ? 550  GLU A CB  1 
ATOM   1925 C  CG  . GLU A 1 287 ? -12.663 -21.208 -25.369 1.00 38.19  ? 550  GLU A CG  1 
ATOM   1926 C  CD  . GLU A 1 287 ? -12.302 -21.787 -24.011 1.00 42.96  ? 550  GLU A CD  1 
ATOM   1927 O  OE1 . GLU A 1 287 ? -13.010 -21.511 -23.004 1.00 44.68  ? 550  GLU A OE1 1 
ATOM   1928 O  OE2 . GLU A 1 287 ? -11.302 -22.536 -23.965 1.00 43.53  ? 550  GLU A OE2 1 
ATOM   1929 N  N   . GLU A 1 288 ? -14.935 -17.287 -26.381 0.50 37.03  ? 551  GLU A N   1 
ATOM   1930 C  CA  . GLU A 1 288 ? -16.011 -16.258 -26.452 0.50 39.04  ? 551  GLU A CA  1 
ATOM   1931 C  C   . GLU A 1 288 ? -16.291 -15.856 -27.908 0.50 37.32  ? 551  GLU A C   1 
ATOM   1932 O  O   . GLU A 1 288 ? -17.425 -15.450 -28.186 0.50 40.49  ? 551  GLU A O   1 
ATOM   1933 C  CB  . GLU A 1 288 ? -15.628 -15.027 -25.626 0.50 40.47  ? 551  GLU A CB  1 
ATOM   1934 C  CG  . GLU A 1 288 ? -16.802 -14.111 -25.305 0.50 42.80  ? 551  GLU A CG  1 
ATOM   1935 C  CD  . GLU A 1 288 ? -17.007 -12.917 -26.231 0.50 43.36  ? 551  GLU A CD  1 
ATOM   1936 O  OE1 . GLU A 1 288 ? -16.192 -12.729 -27.154 0.50 41.37  ? 551  GLU A OE1 1 
ATOM   1937 O  OE2 . GLU A 1 288 ? -17.990 -12.170 -26.021 0.50 46.07  ? 551  GLU A OE2 1 
ATOM   1938 N  N   . MET A 1 289 ? -15.311 -15.966 -28.804 1.00 35.47  ? 552  MET A N   1 
ATOM   1939 C  CA  . MET A 1 289 ? -15.508 -15.599 -30.230 1.00 38.76  ? 552  MET A CA  1 
ATOM   1940 C  C   . MET A 1 289 ? -16.600 -16.454 -30.894 1.00 39.47  ? 552  MET A C   1 
ATOM   1941 O  O   . MET A 1 289 ? -16.982 -16.114 -32.050 1.00 45.03  ? 552  MET A O   1 
ATOM   1942 C  CB  . MET A 1 289 ? -14.214 -15.726 -31.044 1.00 40.10  ? 552  MET A CB  1 
ATOM   1943 C  CG  . MET A 1 289 ? -13.101 -14.848 -30.499 1.00 43.09  ? 552  MET A CG  1 
ATOM   1944 S  SD  . MET A 1 289 ? -11.798 -14.443 -31.694 1.00 51.47  ? 552  MET A SD  1 
ATOM   1945 C  CE  . MET A 1 289 ? -11.504 -15.970 -32.576 1.00 45.74  ? 552  MET A CE  1 
ATOM   1946 N  N   . VAL A 1 290 ? -17.091 -17.543 -30.282 1.00 40.34  ? 553  VAL A N   1 
ATOM   1947 C  CA  . VAL A 1 290 ? -18.297 -18.256 -30.842 1.00 37.57  ? 553  VAL A CA  1 
ATOM   1948 C  C   . VAL A 1 290 ? -19.474 -17.264 -30.886 1.00 37.55  ? 553  VAL A C   1 
ATOM   1949 O  O   . VAL A 1 290 ? -20.314 -17.449 -31.785 1.00 36.63  ? 553  VAL A O   1 
ATOM   1950 C  CB  . VAL A 1 290 ? -18.688 -19.540 -30.080 1.00 34.53  ? 553  VAL A CB  1 
ATOM   1951 C  CG1 . VAL A 1 290 ? -19.073 -19.274 -28.631 1.00 32.30  ? 553  VAL A CG1 1 
ATOM   1952 C  CG2 . VAL A 1 290 ? -19.798 -20.320 -30.793 1.00 33.27  ? 553  VAL A CG2 1 
ATOM   1953 N  N   . THR A 1 291 ? -19.531 -16.258 -29.986 1.00 37.44  ? 554  THR A N   1 
ATOM   1954 C  CA  . THR A 1 291 ? -20.630 -15.244 -29.927 1.00 38.69  ? 554  THR A CA  1 
ATOM   1955 C  C   . THR A 1 291 ? -20.663 -14.392 -31.194 1.00 38.21  ? 554  THR A C   1 
ATOM   1956 O  O   . THR A 1 291 ? -21.766 -13.991 -31.602 1.00 39.71  ? 554  THR A O   1 
ATOM   1957 C  CB  . THR A 1 291 ? -20.541 -14.298 -28.737 1.00 36.31  ? 554  THR A CB  1 
ATOM   1958 O  OG1 . THR A 1 291 ? -19.262 -13.669 -28.801 1.00 39.27  ? 554  THR A OG1 1 
ATOM   1959 C  CG2 . THR A 1 291 ? -20.737 -15.009 -27.421 1.00 38.54  ? 554  THR A CG2 1 
ATOM   1960 N  N   . ASN A 1 292 ? -19.521 -14.163 -31.820 1.00 40.50  ? 555  ASN A N   1 
ATOM   1961 C  CA  . ASN A 1 292 ? -19.443 -13.528 -33.166 1.00 44.45  ? 555  ASN A CA  1 
ATOM   1962 C  C   . ASN A 1 292 ? -20.284 -14.275 -34.199 1.00 46.04  ? 555  ASN A C   1 
ATOM   1963 O  O   . ASN A 1 292 ? -20.377 -13.730 -35.329 1.00 47.87  ? 555  ASN A O   1 
ATOM   1964 C  CB  . ASN A 1 292 ? -18.040 -13.531 -33.786 1.00 44.07  ? 555  ASN A CB  1 
ATOM   1965 C  CG  . ASN A 1 292 ? -17.048 -12.770 -32.943 1.00 46.26  ? 555  ASN A CG  1 
ATOM   1966 O  OD1 . ASN A 1 292 ? -17.444 -11.947 -32.126 1.00 52.62  ? 555  ASN A OD1 1 
ATOM   1967 N  ND2 . ASN A 1 292 ? -15.773 -13.087 -33.092 1.00 51.10  ? 555  ASN A ND2 1 
ATOM   1968 N  N   . HIS A 1 293 ? -20.769 -15.496 -33.919 1.00 39.34  ? 556  HIS A N   1 
ATOM   1969 C  CA  . HIS A 1 293 ? -21.554 -16.284 -34.921 1.00 42.49  ? 556  HIS A CA  1 
ATOM   1970 C  C   . HIS A 1 293 ? -23.054 -16.221 -34.595 1.00 35.71  ? 556  HIS A C   1 
ATOM   1971 O  O   . HIS A 1 293 ? -23.850 -16.872 -35.292 1.00 36.78  ? 556  HIS A O   1 
ATOM   1972 C  CB  . HIS A 1 293 ? -20.970 -17.701 -35.088 1.00 41.00  ? 556  HIS A CB  1 
ATOM   1973 C  CG  . HIS A 1 293 ? -19.570 -17.657 -35.600 1.00 41.34  ? 556  HIS A CG  1 
ATOM   1974 N  ND1 . HIS A 1 293 ? -19.276 -17.827 -36.929 1.00 42.42  ? 556  HIS A ND1 1 
ATOM   1975 C  CD2 . HIS A 1 293 ? -18.398 -17.383 -34.983 1.00 42.40  ? 556  HIS A CD2 1 
ATOM   1976 C  CE1 . HIS A 1 293 ? -17.981 -17.672 -37.113 1.00 37.89  ? 556  HIS A CE1 1 
ATOM   1977 N  NE2 . HIS A 1 293 ? -17.421 -17.391 -35.944 1.00 39.12  ? 556  HIS A NE2 1 
ATOM   1978 N  N   . MET A 1 294 ? -23.395 -15.452 -33.572 1.00 35.67  ? 557  MET A N   1 
ATOM   1979 C  CA  . MET A 1 294 ? -24.733 -15.390 -32.945 1.00 43.75  ? 557  MET A CA  1 
ATOM   1980 C  C   . MET A 1 294 ? -25.413 -14.064 -33.301 1.00 45.25  ? 557  MET A C   1 
ATOM   1981 O  O   . MET A 1 294 ? -24.837 -13.252 -34.055 1.00 45.54  ? 557  MET A O   1 
ATOM   1982 C  CB  . MET A 1 294 ? -24.616 -15.496 -31.421 1.00 46.03  ? 557  MET A CB  1 
ATOM   1983 C  CG  . MET A 1 294 ? -24.083 -16.850 -30.952 1.00 46.15  ? 557  MET A CG  1 
ATOM   1984 S  SD  . MET A 1 294 ? -24.094 -16.933 -29.165 1.00 43.67  ? 557  MET A SD  1 
ATOM   1985 C  CE  . MET A 1 294 ? -23.087 -18.390 -28.916 1.00 47.86  ? 557  MET A CE  1 
ATOM   1986 N  N   . GLU A 1 295 ? -26.613 -13.865 -32.779 1.00 51.50  ? 558  GLU A N   1 
ATOM   1987 C  CA  . GLU A 1 295 ? -27.433 -12.682 -33.112 1.00 54.46  ? 558  GLU A CA  1 
ATOM   1988 C  C   . GLU A 1 295 ? -28.463 -12.376 -32.033 1.00 51.84  ? 558  GLU A C   1 
ATOM   1989 O  O   . GLU A 1 295 ? -28.841 -13.285 -31.257 1.00 52.90  ? 558  GLU A O   1 
ATOM   1990 C  CB  . GLU A 1 295 ? -28.151 -12.953 -34.420 1.00 56.60  ? 558  GLU A CB  1 
ATOM   1991 C  CG  . GLU A 1 295 ? -29.150 -14.062 -34.310 1.00 61.81  ? 558  GLU A CG  1 
ATOM   1992 C  CD  . GLU A 1 295 ? -30.014 -14.126 -35.540 1.00 70.85  ? 558  GLU A CD  1 
ATOM   1993 O  OE1 . GLU A 1 295 ? -29.453 -13.957 -36.659 1.00 77.20  ? 558  GLU A OE1 1 
ATOM   1994 O  OE2 . GLU A 1 295 ? -31.236 -14.303 -35.370 1.00 85.09  ? 558  GLU A OE2 1 
ATOM   1995 N  N   . GLY A 1 296 ? -28.913 -11.124 -32.031 1.00 55.64  ? 559  GLY A N   1 
ATOM   1996 C  CA  . GLY A 1 296 ? -30.007 -10.651 -31.172 1.00 49.64  ? 559  GLY A CA  1 
ATOM   1997 C  C   . GLY A 1 296 ? -29.773 -11.047 -29.734 1.00 49.49  ? 559  GLY A C   1 
ATOM   1998 O  O   . GLY A 1 296 ? -28.607 -10.987 -29.283 1.00 49.62  ? 559  GLY A O   1 
ATOM   1999 N  N   . GLU A 1 297 ? -30.853 -11.453 -29.072 1.00 47.41  ? 560  GLU A N   1 
ATOM   2000 C  CA  . GLU A 1 297 ? -30.904 -11.828 -27.641 1.00 54.61  ? 560  GLU A CA  1 
ATOM   2001 C  C   . GLU A 1 297 ? -29.830 -12.892 -27.345 1.00 57.80  ? 560  GLU A C   1 
ATOM   2002 O  O   . GLU A 1 297 ? -29.096 -12.751 -26.338 1.00 58.51  ? 560  GLU A O   1 
ATOM   2003 C  CB  . GLU A 1 297 ? -32.316 -12.332 -27.349 1.00 55.57  ? 560  GLU A CB  1 
ATOM   2004 C  CG  . GLU A 1 297 ? -32.537 -12.722 -25.905 1.00 64.32  ? 560  GLU A CG  1 
ATOM   2005 C  CD  . GLU A 1 297 ? -33.994 -12.718 -25.482 1.00 71.20  ? 560  GLU A CD  1 
ATOM   2006 O  OE1 . GLU A 1 297 ? -34.424 -13.690 -24.804 1.00 81.04  ? 560  GLU A OE1 1 
ATOM   2007 O  OE2 . GLU A 1 297 ? -34.687 -11.738 -25.807 1.00 69.43  ? 560  GLU A OE2 1 
ATOM   2008 N  N   . HIS A 1 298 ? -29.754 -13.923 -28.189 1.00 50.72  ? 561  HIS A N   1 
ATOM   2009 C  CA  . HIS A 1 298 ? -28.888 -15.099 -27.977 1.00 51.39  ? 561  HIS A CA  1 
ATOM   2010 C  C   . HIS A 1 298 ? -27.474 -14.563 -27.781 1.00 47.35  ? 561  HIS A C   1 
ATOM   2011 O  O   . HIS A 1 298 ? -26.885 -14.812 -26.707 1.00 46.72  ? 561  HIS A O   1 
ATOM   2012 C  CB  . HIS A 1 298 ? -29.014 -16.125 -29.112 1.00 50.07  ? 561  HIS A CB  1 
ATOM   2013 C  CG  . HIS A 1 298 ? -28.168 -17.333 -28.852 1.00 51.49  ? 561  HIS A CG  1 
ATOM   2014 N  ND1 . HIS A 1 298 ? -27.645 -18.120 -29.864 1.00 47.20  ? 561  HIS A ND1 1 
ATOM   2015 C  CD2 . HIS A 1 298 ? -27.713 -17.855 -27.690 1.00 44.52  ? 561  HIS A CD2 1 
ATOM   2016 C  CE1 . HIS A 1 298 ? -26.934 -19.090 -29.328 1.00 53.94  ? 561  HIS A CE1 1 
ATOM   2017 N  NE2 . HIS A 1 298 ? -26.956 -18.949 -27.995 1.00 48.78  ? 561  HIS A NE2 1 
ATOM   2018 N  N   . LYS A 1 299 ? -27.022 -13.765 -28.742 1.00 43.75  ? 562  LYS A N   1 
ATOM   2019 C  CA  . LYS A 1 299 ? -25.677 -13.159 -28.739 1.00 45.20  ? 562  LYS A CA  1 
ATOM   2020 C  C   . LYS A 1 299 ? -25.435 -12.467 -27.394 1.00 46.78  ? 562  LYS A C   1 
ATOM   2021 O  O   . LYS A 1 299 ? -24.318 -12.599 -26.862 1.00 47.99  ? 562  LYS A O   1 
ATOM   2022 C  CB  . LYS A 1 299 ? -25.510 -12.184 -29.902 1.00 46.15  ? 562  LYS A CB  1 
ATOM   2023 C  CG  . LYS A 1 299 ? -24.210 -11.403 -29.855 1.00 45.31  ? 562  LYS A CG  1 
ATOM   2024 C  CD  . LYS A 1 299 ? -23.800 -10.803 -31.171 1.00 49.43  ? 562  LYS A CD  1 
ATOM   2025 C  CE  . LYS A 1 299 ? -22.615 -9.876  -31.009 1.00 53.59  ? 562  LYS A CE  1 
ATOM   2026 N  NZ  . LYS A 1 299 ? -21.563 -10.187 -32.003 1.00 58.43  ? 562  LYS A NZ  1 
ATOM   2027 N  N   . LYS A 1 300 ? -26.435 -11.774 -26.854 1.00 51.31  ? 563  LYS A N   1 
ATOM   2028 C  CA  . LYS A 1 300 ? -26.279 -10.955 -25.614 1.00 55.50  ? 563  LYS A CA  1 
ATOM   2029 C  C   . LYS A 1 300 ? -26.213 -11.890 -24.414 1.00 43.57  ? 563  LYS A C   1 
ATOM   2030 O  O   . LYS A 1 300 ? -25.419 -11.630 -23.540 1.00 47.90  ? 563  LYS A O   1 
ATOM   2031 C  CB  . LYS A 1 300 ? -27.412 -9.933  -25.407 1.00 63.76  ? 563  LYS A CB  1 
ATOM   2032 C  CG  . LYS A 1 300 ? -27.536 -8.837  -26.465 1.00 68.77  ? 563  LYS A CG  1 
ATOM   2033 C  CD  . LYS A 1 300 ? -26.318 -7.935  -26.612 1.00 77.89  ? 563  LYS A CD  1 
ATOM   2034 C  CE  . LYS A 1 300 ? -26.081 -7.452  -28.033 1.00 89.47  ? 563  LYS A CE  1 
ATOM   2035 N  NZ  . LYS A 1 300 ? -25.008 -6.427  -28.114 1.00 90.87  ? 563  LYS A NZ  1 
ATOM   2036 N  N   . LEU A 1 301 ? -27.030 -12.933 -24.403 1.00 47.44  ? 564  LEU A N   1 
ATOM   2037 C  CA  . LEU A 1 301 ? -27.071 -13.936 -23.307 1.00 54.59  ? 564  LEU A CA  1 
ATOM   2038 C  C   . LEU A 1 301 ? -25.723 -14.690 -23.247 1.00 53.89  ? 564  LEU A C   1 
ATOM   2039 O  O   . LEU A 1 301 ? -25.135 -14.751 -22.156 1.00 47.23  ? 564  LEU A O   1 
ATOM   2040 C  CB  . LEU A 1 301 ? -28.269 -14.862 -23.549 1.00 51.18  ? 564  LEU A CB  1 
ATOM   2041 C  CG  . LEU A 1 301 ? -29.656 -14.246 -23.323 1.00 52.03  ? 564  LEU A CG  1 
ATOM   2042 C  CD1 . LEU A 1 301 ? -30.740 -15.217 -23.718 1.00 47.97  ? 564  LEU A CD1 1 
ATOM   2043 C  CD2 . LEU A 1 301 ? -29.877 -13.828 -21.876 1.00 53.36  ? 564  LEU A CD2 1 
ATOM   2044 N  N   . ALA A 1 302 ? -25.220 -15.187 -24.386 1.00 50.98  ? 565  ALA A N   1 
ATOM   2045 C  CA  . ALA A 1 302 ? -23.923 -15.903 -24.510 1.00 47.85  ? 565  ALA A CA  1 
ATOM   2046 C  C   . ALA A 1 302 ? -22.785 -14.979 -24.052 1.00 49.60  ? 565  ALA A C   1 
ATOM   2047 O  O   . ALA A 1 302 ? -21.949 -15.410 -23.259 1.00 51.71  ? 565  ALA A O   1 
ATOM   2048 C  CB  . ALA A 1 302 ? -23.712 -16.374 -25.939 1.00 44.02  ? 565  ALA A CB  1 
ATOM   2049 N  N   . GLU A 1 303 ? -22.762 -13.741 -24.536 1.00 49.71  ? 566  GLU A N   1 
ATOM   2050 C  CA  . GLU A 1 303 ? -21.771 -12.714 -24.119 1.00 52.02  ? 566  GLU A CA  1 
ATOM   2051 C  C   . GLU A 1 303 ? -21.763 -12.584 -22.596 1.00 46.47  ? 566  GLU A C   1 
ATOM   2052 O  O   . GLU A 1 303 ? -20.658 -12.479 -22.009 1.00 43.64  ? 566  GLU A O   1 
ATOM   2053 C  CB  . GLU A 1 303 ? -22.077 -11.374 -24.784 1.00 50.10  ? 566  GLU A CB  1 
ATOM   2054 C  CG  . GLU A 1 303 ? -21.680 -11.402 -26.237 1.00 57.16  ? 566  GLU A CG  1 
ATOM   2055 C  CD  . GLU A 1 303 ? -21.967 -10.151 -27.037 1.00 59.95  ? 566  GLU A CD  1 
ATOM   2056 O  OE1 . GLU A 1 303 ? -22.723 -9.313  -26.541 1.00 66.36  ? 566  GLU A OE1 1 
ATOM   2057 O  OE2 . GLU A 1 303 ? -21.433 -10.038 -28.170 1.00 66.85  ? 566  GLU A OE2 1 
ATOM   2058 N  N   . ALA A 1 304 ? -22.940 -12.601 -21.984 1.00 39.14  ? 567  ALA A N   1 
ATOM   2059 C  CA  . ALA A 1 304 ? -23.097 -12.360 -20.538 1.00 46.49  ? 567  ALA A CA  1 
ATOM   2060 C  C   . ALA A 1 304 ? -22.529 -13.555 -19.760 1.00 46.97  ? 567  ALA A C   1 
ATOM   2061 O  O   . ALA A 1 304 ? -21.810 -13.334 -18.775 1.00 46.29  ? 567  ALA A O   1 
ATOM   2062 C  CB  . ALA A 1 304 ? -24.542 -12.073 -20.195 1.00 43.41  ? 567  ALA A CB  1 
ATOM   2063 N  N   . ILE A 1 305 ? -22.826 -14.777 -20.188 1.00 48.63  ? 568  ILE A N   1 
ATOM   2064 C  CA  . ILE A 1 305 ? -22.265 -15.982 -19.526 1.00 49.37  ? 568  ILE A CA  1 
ATOM   2065 C  C   . ILE A 1 305 ? -20.731 -15.888 -19.616 1.00 47.67  ? 568  ILE A C   1 
ATOM   2066 O  O   . ILE A 1 305 ? -20.074 -16.043 -18.589 1.00 39.27  ? 568  ILE A O   1 
ATOM   2067 C  CB  . ILE A 1 305 ? -22.830 -17.259 -20.167 1.00 56.30  ? 568  ILE A CB  1 
ATOM   2068 C  CG1 . ILE A 1 305 ? -24.326 -17.448 -19.858 1.00 51.28  ? 568  ILE A CG1 1 
ATOM   2069 C  CG2 . ILE A 1 305 ? -21.982 -18.485 -19.808 1.00 57.74  ? 568  ILE A CG2 1 
ATOM   2070 C  CD1 . ILE A 1 305 ? -24.707 -17.510 -18.392 1.00 45.99  ? 568  ILE A CD1 1 
ATOM   2071 N  N   . PHE A 1 306 ? -20.166 -15.568 -20.780 1.00 46.51  ? 569  PHE A N   1 
ATOM   2072 C  CA  . PHE A 1 306 ? -18.688 -15.522 -20.948 1.00 52.77  ? 569  PHE A CA  1 
ATOM   2073 C  C   . PHE A 1 306 ? -18.099 -14.409 -20.059 1.00 57.23  ? 569  PHE A C   1 
ATOM   2074 O  O   . PHE A 1 306 ? -17.152 -14.715 -19.309 1.00 55.44  ? 569  PHE A O   1 
ATOM   2075 C  CB  . PHE A 1 306 ? -18.285 -15.393 -22.419 1.00 49.26  ? 569  PHE A CB  1 
ATOM   2076 C  CG  . PHE A 1 306 ? -18.174 -16.690 -23.187 1.00 52.18  ? 569  PHE A CG  1 
ATOM   2077 C  CD1 . PHE A 1 306 ? -17.083 -17.529 -23.020 1.00 54.80  ? 569  PHE A CD1 1 
ATOM   2078 C  CD2 . PHE A 1 306 ? -19.113 -17.030 -24.146 1.00 52.15  ? 569  PHE A CD2 1 
ATOM   2079 C  CE1 . PHE A 1 306 ? -16.971 -18.699 -23.756 1.00 55.56  ? 569  PHE A CE1 1 
ATOM   2080 C  CE2 . PHE A 1 306 ? -19.002 -18.205 -24.878 1.00 56.56  ? 569  PHE A CE2 1 
ATOM   2081 C  CZ  . PHE A 1 306 ? -17.938 -19.048 -24.668 1.00 56.77  ? 569  PHE A CZ  1 
ATOM   2082 N  N   . LYS A 1 307 ? -18.651 -13.184 -20.117 1.00 66.34  ? 570  LYS A N   1 
ATOM   2083 C  CA  . LYS A 1 307 ? -18.198 -11.987 -19.344 1.00 63.69  ? 570  LYS A CA  1 
ATOM   2084 C  C   . LYS A 1 307 ? -18.314 -12.249 -17.841 1.00 54.07  ? 570  LYS A C   1 
ATOM   2085 O  O   . LYS A 1 307 ? -17.332 -12.047 -17.120 1.00 55.17  ? 570  LYS A O   1 
ATOM   2086 C  CB  . LYS A 1 307 ? -19.055 -10.748 -19.631 1.00 74.01  ? 570  LYS A CB  1 
ATOM   2087 C  CG  . LYS A 1 307 ? -18.338 -9.544  -20.228 1.00 80.04  ? 570  LYS A CG  1 
ATOM   2088 C  CD  . LYS A 1 307 ? -19.296 -8.523  -20.851 1.00 94.15  ? 570  LYS A CD  1 
ATOM   2089 C  CE  . LYS A 1 307 ? -18.997 -8.212  -22.307 1.00 99.13  ? 570  LYS A CE  1 
ATOM   2090 N  NZ  . LYS A 1 307 ? -18.903 -9.437  -23.146 1.00 97.55  ? 570  LYS A NZ  1 
ATOM   2091 N  N   . LEU A 1 308 ? -19.485 -12.668 -17.387 1.00 48.11  ? 571  LEU A N   1 
ATOM   2092 C  CA  . LEU A 1 308 ? -19.884 -12.481 -15.975 1.00 54.12  ? 571  LEU A CA  1 
ATOM   2093 C  C   . LEU A 1 308 ? -19.639 -13.758 -15.173 1.00 54.54  ? 571  LEU A C   1 
ATOM   2094 O  O   . LEU A 1 308 ? -19.495 -13.636 -13.950 1.00 56.94  ? 571  LEU A O   1 
ATOM   2095 C  CB  . LEU A 1 308 ? -21.361 -12.061 -15.926 1.00 59.76  ? 571  LEU A CB  1 
ATOM   2096 C  CG  . LEU A 1 308 ? -21.717 -10.802 -16.728 1.00 59.51  ? 571  LEU A CG  1 
ATOM   2097 C  CD1 . LEU A 1 308 ? -23.220 -10.675 -16.871 1.00 60.68  ? 571  LEU A CD1 1 
ATOM   2098 C  CD2 . LEU A 1 308 ? -21.135 -9.542  -16.096 1.00 56.39  ? 571  LEU A CD2 1 
ATOM   2099 N  N   . THR A 1 309 ? -19.658 -14.938 -15.794 1.00 52.20  ? 572  THR A N   1 
ATOM   2100 C  CA  . THR A 1 309 ? -19.541 -16.214 -15.036 1.00 54.08  ? 572  THR A CA  1 
ATOM   2101 C  C   . THR A 1 309 ? -18.219 -16.917 -15.357 1.00 48.41  ? 572  THR A C   1 
ATOM   2102 O  O   . THR A 1 309 ? -17.732 -17.578 -14.479 1.00 52.77  ? 572  THR A O   1 
ATOM   2103 C  CB  . THR A 1 309 ? -20.754 -17.131 -15.238 1.00 56.83  ? 572  THR A CB  1 
ATOM   2104 O  OG1 . THR A 1 309 ? -20.827 -17.574 -16.592 1.00 50.61  ? 572  THR A OG1 1 
ATOM   2105 C  CG2 . THR A 1 309 ? -22.057 -16.452 -14.884 1.00 67.56  ? 572  THR A CG2 1 
ATOM   2106 N  N   . TYR A 1 310 ? -17.659 -16.774 -16.558 1.00 47.73  ? 573  TYR A N   1 
ATOM   2107 C  CA  . TYR A 1 310 ? -16.459 -17.542 -16.991 1.00 49.50  ? 573  TYR A CA  1 
ATOM   2108 C  C   . TYR A 1 310 ? -15.207 -16.673 -16.796 1.00 48.52  ? 573  TYR A C   1 
ATOM   2109 O  O   . TYR A 1 310 ? -14.263 -17.174 -16.169 1.00 53.22  ? 573  TYR A O   1 
ATOM   2110 C  CB  . TYR A 1 310 ? -16.591 -18.047 -18.439 1.00 44.71  ? 573  TYR A CB  1 
ATOM   2111 C  CG  . TYR A 1 310 ? -17.622 -19.122 -18.700 1.00 37.60  ? 573  TYR A CG  1 
ATOM   2112 C  CD1 . TYR A 1 310 ? -18.447 -19.616 -17.705 1.00 34.49  ? 573  TYR A CD1 1 
ATOM   2113 C  CD2 . TYR A 1 310 ? -17.822 -19.592 -19.986 1.00 37.14  ? 573  TYR A CD2 1 
ATOM   2114 C  CE1 . TYR A 1 310 ? -19.413 -20.569 -17.974 1.00 35.44  ? 573  TYR A CE1 1 
ATOM   2115 C  CE2 . TYR A 1 310 ? -18.791 -20.539 -20.276 1.00 35.14  ? 573  TYR A CE2 1 
ATOM   2116 C  CZ  . TYR A 1 310 ? -19.579 -21.039 -19.265 1.00 35.34  ? 573  TYR A CZ  1 
ATOM   2117 O  OH  . TYR A 1 310 ? -20.534 -21.971 -19.550 1.00 39.68  ? 573  TYR A OH  1 
ATOM   2118 N  N   . GLN A 1 311 ? -15.212 -15.428 -17.291 1.00 41.86  ? 574  GLN A N   1 
ATOM   2119 C  CA  . GLN A 1 311 ? -14.027 -14.536 -17.301 1.00 43.84  ? 574  GLN A CA  1 
ATOM   2120 C  C   . GLN A 1 311 ? -13.971 -13.721 -16.004 1.00 47.21  ? 574  GLN A C   1 
ATOM   2121 O  O   . GLN A 1 311 ? -12.990 -12.973 -15.836 1.00 45.09  ? 574  GLN A O   1 
ATOM   2122 C  CB  . GLN A 1 311 ? -14.056 -13.647 -18.532 1.00 44.18  ? 574  GLN A CB  1 
ATOM   2123 C  CG  . GLN A 1 311 ? -14.060 -14.447 -19.821 1.00 42.67  ? 574  GLN A CG  1 
ATOM   2124 C  CD  . GLN A 1 311 ? -14.106 -13.492 -20.978 1.00 44.52  ? 574  GLN A CD  1 
ATOM   2125 O  OE1 . GLN A 1 311 ? -14.187 -12.302 -20.776 1.00 53.26  ? 574  GLN A OE1 1 
ATOM   2126 N  NE2 . GLN A 1 311 ? -14.045 -13.990 -22.197 1.00 50.45  ? 574  GLN A NE2 1 
ATOM   2127 N  N   . ASN A 1 312 ? -14.965 -13.904 -15.122 1.00 46.34  ? 575  ASN A N   1 
ATOM   2128 C  CA  . ASN A 1 312 ? -14.989 -13.425 -13.714 1.00 49.52  ? 575  ASN A CA  1 
ATOM   2129 C  C   . ASN A 1 312 ? -15.800 -14.448 -12.929 1.00 50.08  ? 575  ASN A C   1 
ATOM   2130 O  O   . ASN A 1 312 ? -16.845 -14.863 -13.428 1.00 72.85  ? 575  ASN A O   1 
ATOM   2131 C  CB  . ASN A 1 312 ? -15.641 -12.046 -13.548 1.00 46.93  ? 575  ASN A CB  1 
ATOM   2132 C  CG  . ASN A 1 312 ? -14.835 -10.914 -14.141 1.00 50.83  ? 575  ASN A CG  1 
ATOM   2133 O  OD1 . ASN A 1 312 ? -13.977 -10.348 -13.464 1.00 68.32  ? 575  ASN A OD1 1 
ATOM   2134 N  ND2 . ASN A 1 312 ? -15.122 -10.547 -15.382 1.00 50.22  ? 575  ASN A ND2 1 
ATOM   2135 N  N   . LYS A 1 313 ? -15.322 -14.879 -11.774 1.00 52.68  ? 576  LYS A N   1 
ATOM   2136 C  CA  . LYS A 1 313 ? -15.878 -16.072 -11.097 1.00 57.49  ? 576  LYS A CA  1 
ATOM   2137 C  C   . LYS A 1 313 ? -16.002 -15.794 -9.604  1.00 58.34  ? 576  LYS A C   1 
ATOM   2138 O  O   . LYS A 1 313 ? -15.078 -15.221 -9.041  1.00 63.05  ? 576  LYS A O   1 
ATOM   2139 C  CB  . LYS A 1 313 ? -14.965 -17.288 -11.264 1.00 60.34  ? 576  LYS A CB  1 
ATOM   2140 C  CG  . LYS A 1 313 ? -14.632 -17.703 -12.688 1.00 57.83  ? 576  LYS A CG  1 
ATOM   2141 C  CD  . LYS A 1 313 ? -13.877 -19.003 -12.671 1.00 61.86  ? 576  LYS A CD  1 
ATOM   2142 C  CE  . LYS A 1 313 ? -13.310 -19.438 -14.002 1.00 63.45  ? 576  LYS A CE  1 
ATOM   2143 N  NZ  . LYS A 1 313 ? -12.361 -18.446 -14.555 1.00 71.75  ? 576  LYS A NZ  1 
ATOM   2144 N  N   . VAL A 1 314 ? -17.092 -16.231 -8.997  1.00 53.16  ? 577  VAL A N   1 
ATOM   2145 C  CA  . VAL A 1 314 ? -17.265 -16.164 -7.530  1.00 55.16  ? 577  VAL A CA  1 
ATOM   2146 C  C   . VAL A 1 314 ? -17.566 -17.580 -7.101  1.00 54.65  ? 577  VAL A C   1 
ATOM   2147 O  O   . VAL A 1 314 ? -18.426 -18.232 -7.731  1.00 50.42  ? 577  VAL A O   1 
ATOM   2148 C  CB  . VAL A 1 314 ? -18.375 -15.184 -7.090  1.00 61.97  ? 577  VAL A CB  1 
ATOM   2149 C  CG1 . VAL A 1 314 ? -18.625 -15.269 -5.587  1.00 59.51  ? 577  VAL A CG1 1 
ATOM   2150 C  CG2 . VAL A 1 314 ? -18.071 -13.746 -7.504  1.00 56.07  ? 577  VAL A CG2 1 
ATOM   2151 N  N   . VAL A 1 315 ? -16.868 -18.012 -6.061  1.00 56.08  ? 578  VAL A N   1 
ATOM   2152 C  CA  . VAL A 1 315 ? -16.900 -19.415 -5.597  1.00 59.33  ? 578  VAL A CA  1 
ATOM   2153 C  C   . VAL A 1 315 ? -17.036 -19.409 -4.085  1.00 57.01  ? 578  VAL A C   1 
ATOM   2154 O  O   . VAL A 1 315 ? -16.340 -18.626 -3.444  1.00 62.80  ? 578  VAL A O   1 
ATOM   2155 C  CB  . VAL A 1 315 ? -15.626 -20.152 -6.034  1.00 66.06  ? 578  VAL A CB  1 
ATOM   2156 C  CG1 . VAL A 1 315 ? -15.774 -21.643 -5.800  1.00 70.26  ? 578  VAL A CG1 1 
ATOM   2157 C  CG2 . VAL A 1 315 ? -15.252 -19.841 -7.480  1.00 65.98  ? 578  VAL A CG2 1 
ATOM   2158 N  N   . ARG A 1 316 ? -17.841 -20.316 -3.557  1.00 62.89  ? 579  ARG A N   1 
ATOM   2159 C  CA  . ARG A 1 316 ? -17.912 -20.570 -2.105  1.00 71.58  ? 579  ARG A CA  1 
ATOM   2160 C  C   . ARG A 1 316 ? -17.207 -21.904 -1.836  1.00 73.93  ? 579  ARG A C   1 
ATOM   2161 O  O   . ARG A 1 316 ? -17.517 -22.884 -2.521  1.00 79.17  ? 579  ARG A O   1 
ATOM   2162 C  CB  . ARG A 1 316 ? -19.362 -20.466 -1.631  1.00 71.24  ? 579  ARG A CB  1 
ATOM   2163 C  CG  . ARG A 1 316 ? -20.353 -21.305 -2.411  1.00 82.03  ? 579  ARG A CG  1 
ATOM   2164 C  CD  . ARG A 1 316 ? -21.698 -21.219 -1.727  1.00 93.98  ? 579  ARG A CD  1 
ATOM   2165 N  NE  . ARG A 1 316 ? -22.312 -19.911 -1.881  1.00 103.11 ? 579  ARG A NE  1 
ATOM   2166 C  CZ  . ARG A 1 316 ? -23.520 -19.593 -1.430  1.00 108.37 ? 579  ARG A CZ  1 
ATOM   2167 N  NH1 . ARG A 1 316 ? -23.994 -18.374 -1.625  1.00 110.60 ? 579  ARG A NH1 1 
ATOM   2168 N  NH2 . ARG A 1 316 ? -24.249 -20.492 -0.786  1.00 107.26 ? 579  ARG A NH2 1 
ATOM   2169 N  N   . VAL A 1 317 ? -16.245 -21.905 -0.908  1.00 81.83  ? 580  VAL A N   1 
ATOM   2170 C  CA  . VAL A 1 317 ? -15.416 -23.089 -0.538  1.00 87.08  ? 580  VAL A CA  1 
ATOM   2171 C  C   . VAL A 1 317 ? -15.504 -23.315 0.977   1.00 91.43  ? 580  VAL A C   1 
ATOM   2172 O  O   . VAL A 1 317 ? -15.488 -22.335 1.725   1.00 87.96  ? 580  VAL A O   1 
ATOM   2173 C  CB  . VAL A 1 317 ? -13.953 -22.880 -0.967  1.00 80.63  ? 580  VAL A CB  1 
ATOM   2174 C  CG1 . VAL A 1 317 ? -13.336 -24.186 -1.435  1.00 78.70  ? 580  VAL A CG1 1 
ATOM   2175 C  CG2 . VAL A 1 317 ? -13.807 -21.810 -2.035  1.00 84.43  ? 580  VAL A CG2 1 
ATOM   2176 N  N   . GLN A 1 318 ? -15.584 -24.581 1.401   0.40 97.03  ? 581  GLN A N   1 
ATOM   2177 C  CA  . GLN A 1 318 ? -15.569 -24.995 2.831   0.40 101.94 ? 581  GLN A CA  1 
ATOM   2178 C  C   . GLN A 1 318 ? -14.118 -25.154 3.302   0.40 103.99 ? 581  GLN A C   1 
ATOM   2179 O  O   . GLN A 1 318 ? -13.346 -25.842 2.603   0.40 104.25 ? 581  GLN A O   1 
ATOM   2180 C  CB  . GLN A 1 318 ? -16.335 -26.304 3.028   0.40 101.69 ? 581  GLN A CB  1 
ATOM   2181 C  CG  . GLN A 1 318 ? -17.814 -26.100 3.316   0.40 104.68 ? 581  GLN A CG  1 
ATOM   2182 C  CD  . GLN A 1 318 ? -18.393 -27.240 4.115   0.40 108.41 ? 581  GLN A CD  1 
ATOM   2183 O  OE1 . GLN A 1 318 ? -17.799 -28.310 4.226   0.40 111.42 ? 581  GLN A OE1 1 
ATOM   2184 N  NE2 . GLN A 1 318 ? -19.565 -27.015 4.687   0.40 111.01 ? 581  GLN A NE2 1 
ATOM   2185 N  N   . ARG A 1 319 ? -13.777 -24.546 4.444   1.00 106.33 ? 582  ARG A N   1 
ATOM   2186 C  CA  . ARG A 1 319 ? -12.416 -24.624 5.056   1.00 111.46 ? 582  ARG A CA  1 
ATOM   2187 C  C   . ARG A 1 319 ? -12.566 -25.059 6.512   1.00 116.46 ? 582  ARG A C   1 
ATOM   2188 O  O   . ARG A 1 319 ? -13.372 -24.469 7.219   1.00 116.19 ? 582  ARG A O   1 
ATOM   2189 C  CB  . ARG A 1 319 ? -11.707 -23.270 4.958   1.00 105.08 ? 582  ARG A CB  1 
ATOM   2190 C  CG  . ARG A 1 319 ? -10.301 -23.272 5.537   1.00 102.16 ? 582  ARG A CG  1 
ATOM   2191 C  CD  . ARG A 1 319 ? -9.440  -22.203 4.904   1.00 105.55 ? 582  ARG A CD  1 
ATOM   2192 N  NE  . ARG A 1 319 ? -9.987  -20.870 5.107   1.00 103.18 ? 582  ARG A NE  1 
ATOM   2193 C  CZ  . ARG A 1 319 ? -9.599  -20.011 6.050   1.00 113.49 ? 582  ARG A CZ  1 
ATOM   2194 N  NH1 . ARG A 1 319 ? -8.646  -20.330 6.911   1.00 115.07 ? 582  ARG A NH1 1 
ATOM   2195 N  NH2 . ARG A 1 319 ? -10.168 -18.821 6.126   1.00 118.05 ? 582  ARG A NH2 1 
ATOM   2196 N  N   . PRO A 1 320 ? -11.802 -26.065 7.013   1.00 127.62 ? 583  PRO A N   1 
ATOM   2197 C  CA  . PRO A 1 320 ? -12.062 -26.659 8.329   1.00 124.43 ? 583  PRO A CA  1 
ATOM   2198 C  C   . PRO A 1 320 ? -11.624 -25.805 9.536   1.00 121.65 ? 583  PRO A C   1 
ATOM   2199 O  O   . PRO A 1 320 ? -12.112 -26.041 10.634  1.00 112.12 ? 583  PRO A O   1 
ATOM   2200 C  CB  . PRO A 1 320 ? -11.258 -27.977 8.314   1.00 124.57 ? 583  PRO A CB  1 
ATOM   2201 C  CG  . PRO A 1 320 ? -10.670 -28.096 6.914   1.00 122.15 ? 583  PRO A CG  1 
ATOM   2202 C  CD  . PRO A 1 320 ? -10.639 -26.688 6.361   1.00 127.22 ? 583  PRO A CD  1 
ATOM   2203 N  N   . THR A 1 321 ? -10.731 -24.836 9.313   1.00 119.62 ? 584  THR A N   1 
ATOM   2204 C  CA  . THR A 1 321 ? -10.193 -23.913 10.349  1.00 126.65 ? 584  THR A CA  1 
ATOM   2205 C  C   . THR A 1 321 ? -11.324 -23.024 10.888  1.00 114.34 ? 584  THR A C   1 
ATOM   2206 O  O   . THR A 1 321 ? -11.756 -23.274 12.030  1.00 110.33 ? 584  THR A O   1 
ATOM   2207 C  CB  . THR A 1 321 ? -9.049  -23.067 9.777   1.00 134.90 ? 584  THR A CB  1 
ATOM   2208 O  OG1 . THR A 1 321 ? -9.585  -22.266 8.723   1.00 132.64 ? 584  THR A OG1 1 
ATOM   2209 C  CG2 . THR A 1 321 ? -7.894  -23.891 9.248   1.00 133.72 ? 584  THR A CG2 1 
ATOM   2210 N  N   . THR A 1 325 ? -15.640 -24.883 10.818  0.40 107.54 ? 588  THR A N   1 
ATOM   2211 C  CA  . THR A 1 325 ? -15.757 -24.846 9.335   0.40 107.40 ? 588  THR A CA  1 
ATOM   2212 C  C   . THR A 1 325 ? -16.395 -23.519 8.904   0.40 107.58 ? 588  THR A C   1 
ATOM   2213 O  O   . THR A 1 325 ? -17.549 -23.268 9.309   0.40 106.77 ? 588  THR A O   1 
ATOM   2214 C  CB  . THR A 1 325 ? -16.567 -26.041 8.814   0.40 107.84 ? 588  THR A CB  1 
ATOM   2215 O  OG1 . THR A 1 325 ? -15.877 -27.242 9.162   0.40 108.37 ? 588  THR A OG1 1 
ATOM   2216 C  CG2 . THR A 1 325 ? -16.779 -26.003 7.317   0.40 109.25 ? 588  THR A CG2 1 
ATOM   2217 N  N   . VAL A 1 326 ? -15.673 -22.713 8.115   1.00 107.70 ? 589  VAL A N   1 
ATOM   2218 C  CA  . VAL A 1 326 ? -16.204 -21.445 7.516   1.00 105.80 ? 589  VAL A CA  1 
ATOM   2219 C  C   . VAL A 1 326 ? -16.403 -21.696 6.015   1.00 104.34 ? 589  VAL A C   1 
ATOM   2220 O  O   . VAL A 1 326 ? -15.846 -22.688 5.494   1.00 105.86 ? 589  VAL A O   1 
ATOM   2221 C  CB  . VAL A 1 326 ? -15.298 -20.219 7.764   1.00 109.38 ? 589  VAL A CB  1 
ATOM   2222 C  CG1 . VAL A 1 326 ? -14.653 -20.255 9.140   1.00 114.69 ? 589  VAL A CG1 1 
ATOM   2223 C  CG2 . VAL A 1 326 ? -14.242 -20.033 6.681   1.00 109.77 ? 589  VAL A CG2 1 
ATOM   2224 N  N   . MET A 1 327 ? -17.195 -20.840 5.364   1.00 98.71  ? 590  MET A N   1 
ATOM   2225 C  CA  . MET A 1 327 ? -17.304 -20.743 3.885   1.00 92.40  ? 590  MET A CA  1 
ATOM   2226 C  C   . MET A 1 327 ? -16.526 -19.502 3.445   1.00 81.28  ? 590  MET A C   1 
ATOM   2227 O  O   . MET A 1 327 ? -16.888 -18.413 3.902   1.00 70.88  ? 590  MET A O   1 
ATOM   2228 C  CB  . MET A 1 327 ? -18.763 -20.617 3.436   1.00 92.17  ? 590  MET A CB  1 
ATOM   2229 C  CG  . MET A 1 327 ? -18.970 -20.866 1.952   1.00 89.14  ? 590  MET A CG  1 
ATOM   2230 S  SD  . MET A 1 327 ? -18.728 -22.606 1.464   1.00 90.69  ? 590  MET A SD  1 
ATOM   2231 C  CE  . MET A 1 327 ? -20.295 -23.334 1.949   1.00 85.06  ? 590  MET A CE  1 
ATOM   2232 N  N   . ASP A 1 328 ? -15.484 -19.681 2.627   1.00 80.82  ? 591  ASP A N   1 
ATOM   2233 C  CA  . ASP A 1 328 ? -14.641 -18.593 2.060   1.00 83.71  ? 591  ASP A CA  1 
ATOM   2234 C  C   . ASP A 1 328 ? -15.198 -18.200 0.691   1.00 82.27  ? 591  ASP A C   1 
ATOM   2235 O  O   . ASP A 1 328 ? -15.474 -19.101 -0.121  1.00 92.37  ? 591  ASP A O   1 
ATOM   2236 C  CB  . ASP A 1 328 ? -13.178 -19.023 1.932   1.00 89.83  ? 591  ASP A CB  1 
ATOM   2237 C  CG  . ASP A 1 328 ? -12.503 -19.277 3.270   1.00 96.50  ? 591  ASP A CG  1 
ATOM   2238 O  OD1 . ASP A 1 328 ? -12.177 -18.279 3.946   1.00 101.32 ? 591  ASP A OD1 1 
ATOM   2239 O  OD2 . ASP A 1 328 ? -12.322 -20.474 3.635   1.00 86.16  ? 591  ASP A OD2 1 
ATOM   2240 N  N   . ILE A 1 329 ? -15.359 -16.903 0.448   1.00 70.03  ? 592  ILE A N   1 
ATOM   2241 C  CA  . ILE A 1 329 ? -15.888 -16.378 -0.835  1.00 66.46  ? 592  ILE A CA  1 
ATOM   2242 C  C   . ILE A 1 329 ? -14.696 -15.816 -1.592  1.00 71.10  ? 592  ILE A C   1 
ATOM   2243 O  O   . ILE A 1 329 ? -14.225 -14.709 -1.260  1.00 69.61  ? 592  ILE A O   1 
ATOM   2244 C  CB  . ILE A 1 329 ? -17.003 -15.338 -0.615  1.00 69.99  ? 592  ILE A CB  1 
ATOM   2245 C  CG1 . ILE A 1 329 ? -18.233 -15.949 0.066   1.00 71.22  ? 592  ILE A CG1 1 
ATOM   2246 C  CG2 . ILE A 1 329 ? -17.362 -14.640 -1.917  1.00 70.89  ? 592  ILE A CG2 1 
ATOM   2247 C  CD1 . ILE A 1 329 ? -18.617 -17.338 -0.399  1.00 72.42  ? 592  ILE A CD1 1 
ATOM   2248 N  N   . ILE A 1 330 ? -14.230 -16.581 -2.573  1.00 75.03  ? 593  ILE A N   1 
ATOM   2249 C  CA  . ILE A 1 330 ? -12.983 -16.278 -3.324  1.00 72.76  ? 593  ILE A CA  1 
ATOM   2250 C  C   . ILE A 1 330 ? -13.393 -15.964 -4.757  1.00 63.29  ? 593  ILE A C   1 
ATOM   2251 O  O   . ILE A 1 330 ? -14.476 -16.392 -5.128  1.00 60.37  ? 593  ILE A O   1 
ATOM   2252 C  CB  . ILE A 1 330 ? -12.003 -17.458 -3.201  1.00 77.67  ? 593  ILE A CB  1 
ATOM   2253 C  CG1 . ILE A 1 330 ? -12.659 -18.799 -3.558  1.00 79.62  ? 593  ILE A CG1 1 
ATOM   2254 C  CG2 . ILE A 1 330 ? -11.421 -17.475 -1.799  1.00 79.80  ? 593  ILE A CG2 1 
ATOM   2255 C  CD1 . ILE A 1 330 ? -11.686 -19.925 -3.867  1.00 72.16  ? 593  ILE A CD1 1 
ATOM   2256 N  N   . SER A 1 331 ? -12.563 -15.228 -5.495  1.00 61.12  ? 594  SER A N   1 
ATOM   2257 C  CA  . SER A 1 331 ? -12.773 -14.893 -6.922  1.00 58.98  ? 594  SER A CA  1 
ATOM   2258 C  C   . SER A 1 331 ? -11.465 -15.051 -7.717  1.00 61.61  ? 594  SER A C   1 
ATOM   2259 O  O   . SER A 1 331 ? -10.391 -14.999 -7.111  1.00 62.76  ? 594  SER A O   1 
ATOM   2260 C  CB  . SER A 1 331 ? -13.324 -13.506 -7.031  1.00 55.61  ? 594  SER A CB  1 
ATOM   2261 O  OG  . SER A 1 331 ? -12.290 -12.559 -6.869  1.00 58.71  ? 594  SER A OG  1 
ATOM   2262 N  N   . ARG A 1 332 ? -11.572 -15.255 -9.034  1.00 63.38  ? 595  ARG A N   1 
ATOM   2263 C  CA  . ARG A 1 332 ? -10.455 -15.246 -10.020 1.00 60.23  ? 595  ARG A CA  1 
ATOM   2264 C  C   . ARG A 1 332 ? -11.059 -15.151 -11.418 1.00 59.53  ? 595  ARG A C   1 
ATOM   2265 O  O   . ARG A 1 332 ? -12.276 -15.413 -11.576 1.00 62.84  ? 595  ARG A O   1 
ATOM   2266 C  CB  . ARG A 1 332 ? -9.595  -16.507 -9.941  1.00 64.37  ? 595  ARG A CB  1 
ATOM   2267 C  CG  . ARG A 1 332 ? -10.139 -17.676 -10.746 1.00 66.19  ? 595  ARG A CG  1 
ATOM   2268 C  CD  . ARG A 1 332 ? -9.227  -18.888 -10.699 1.00 70.52  ? 595  ARG A CD  1 
ATOM   2269 N  NE  . ARG A 1 332 ? -7.864  -18.626 -11.157 1.00 66.05  ? 595  ARG A NE  1 
ATOM   2270 C  CZ  . ARG A 1 332 ? -6.763  -18.757 -10.413 1.00 63.45  ? 595  ARG A CZ  1 
ATOM   2271 N  NH1 . ARG A 1 332 ? -6.841  -19.136 -9.147  1.00 63.99  ? 595  ARG A NH1 1 
ATOM   2272 N  NH2 . ARG A 1 332 ? -5.579  -18.520 -10.948 1.00 57.18  ? 595  ARG A NH2 1 
ATOM   2273 N  N   . ARG A 1 333 ? -10.227 -14.804 -12.407 0.26 59.16  ? 596  ARG A N   1 
ATOM   2274 C  CA  . ARG A 1 333 ? -10.641 -14.470 -13.798 0.26 60.90  ? 596  ARG A CA  1 
ATOM   2275 C  C   . ARG A 1 333 ? -10.281 -15.592 -14.787 0.26 60.59  ? 596  ARG A C   1 
ATOM   2276 O  O   . ARG A 1 333 ? -10.939 -15.661 -15.845 0.26 59.71  ? 596  ARG A O   1 
ATOM   2277 C  CB  . ARG A 1 333 ? -9.976  -13.165 -14.243 0.26 61.46  ? 596  ARG A CB  1 
ATOM   2278 C  CG  . ARG A 1 333 ? -10.533 -11.919 -13.568 0.26 63.75  ? 596  ARG A CG  1 
ATOM   2279 C  CD  . ARG A 1 333 ? -10.192 -10.662 -14.347 0.26 64.84  ? 596  ARG A CD  1 
ATOM   2280 N  NE  . ARG A 1 333 ? -10.800 -10.669 -15.673 0.26 66.45  ? 596  ARG A NE  1 
ATOM   2281 C  CZ  . ARG A 1 333 ? -10.383 -9.955  -16.720 0.26 68.22  ? 596  ARG A CZ  1 
ATOM   2282 N  NH1 . ARG A 1 333 ? -9.334  -9.152  -16.618 0.26 67.91  ? 596  ARG A NH1 1 
ATOM   2283 N  NH2 . ARG A 1 333 ? -11.019 -10.052 -17.875 0.26 67.09  ? 596  ARG A NH2 1 
ATOM   2284 N  N   . ASP A 1 334 ? -9.272  -16.415 -14.478 0.26 59.57  ? 597  ASP A N   1 
ATOM   2285 C  CA  . ASP A 1 334 ? -8.738  -17.469 -15.385 0.26 58.33  ? 597  ASP A CA  1 
ATOM   2286 C  C   . ASP A 1 334 ? -9.123  -18.854 -14.844 0.26 56.48  ? 597  ASP A C   1 
ATOM   2287 O  O   . ASP A 1 334 ? -9.830  -18.910 -13.820 0.26 53.77  ? 597  ASP A O   1 
ATOM   2288 C  CB  . ASP A 1 334 ? -7.226  -17.308 -15.584 0.26 58.60  ? 597  ASP A CB  1 
ATOM   2289 C  CG  . ASP A 1 334 ? -6.402  -17.475 -14.319 0.26 58.76  ? 597  ASP A CG  1 
ATOM   2290 O  OD1 . ASP A 1 334 ? -6.917  -17.140 -13.232 0.26 58.71  ? 597  ASP A OD1 1 
ATOM   2291 O  OD2 . ASP A 1 334 ? -5.249  -17.938 -14.431 0.26 60.78  ? 597  ASP A OD2 1 
ATOM   2292 N  N   . GLN A 1 335 ? -8.692  -19.918 -15.536 0.26 55.07  ? 598  GLN A N   1 
ATOM   2293 C  CA  . GLN A 1 335 ? -9.008  -21.347 -15.249 0.26 53.95  ? 598  GLN A CA  1 
ATOM   2294 C  C   . GLN A 1 335 ? -10.423 -21.672 -15.743 0.26 53.33  ? 598  GLN A C   1 
ATOM   2295 O  O   . GLN A 1 335 ? -11.215 -20.731 -15.960 0.26 53.78  ? 598  GLN A O   1 
ATOM   2296 C  CB  . GLN A 1 335 ? -8.880  -21.682 -13.761 0.26 54.25  ? 598  GLN A CB  1 
ATOM   2297 C  CG  . GLN A 1 335 ? -7.500  -21.400 -13.182 0.26 54.31  ? 598  GLN A CG  1 
ATOM   2298 C  CD  . GLN A 1 335 ? -7.375  -21.855 -11.748 0.26 54.75  ? 598  GLN A CD  1 
ATOM   2299 O  OE1 . GLN A 1 335 ? -8.356  -21.941 -11.011 0.26 55.39  ? 598  GLN A OE1 1 
ATOM   2300 N  NE2 . GLN A 1 335 ? -6.152  -22.148 -11.336 0.26 53.94  ? 598  GLN A NE2 1 
ATOM   2301 N  N   . ARG A 1 336 ? -10.709 -22.967 -15.906 1.00 51.65  ? 599  ARG A N   1 
ATOM   2302 C  CA  . ARG A 1 336 ? -12.017 -23.479 -16.367 1.00 53.98  ? 599  ARG A CA  1 
ATOM   2303 C  C   . ARG A 1 336 ? -12.923 -23.690 -15.166 1.00 56.96  ? 599  ARG A C   1 
ATOM   2304 O  O   . ARG A 1 336 ? -12.479 -24.259 -14.143 1.00 55.80  ? 599  ARG A O   1 
ATOM   2305 C  CB  . ARG A 1 336 ? -11.900 -24.815 -17.101 1.00 49.83  ? 599  ARG A CB  1 
ATOM   2306 C  CG  . ARG A 1 336 ? -13.236 -25.439 -17.469 1.00 45.02  ? 599  ARG A CG  1 
ATOM   2307 C  CD  . ARG A 1 336 ? -13.843 -24.683 -18.624 1.00 43.49  ? 599  ARG A CD  1 
ATOM   2308 N  NE  . ARG A 1 336 ? -13.061 -24.976 -19.792 1.00 40.97  ? 599  ARG A NE  1 
ATOM   2309 C  CZ  . ARG A 1 336 ? -12.753 -24.122 -20.749 1.00 41.40  ? 599  ARG A CZ  1 
ATOM   2310 N  NH1 . ARG A 1 336 ? -13.158 -22.864 -20.699 1.00 39.43  ? 599  ARG A NH1 1 
ATOM   2311 N  NH2 . ARG A 1 336 ? -12.058 -24.564 -21.784 1.00 41.34  ? 599  ARG A NH2 1 
ATOM   2312 N  N   . GLY A 1 337 ? -14.159 -23.249 -15.367 1.00 67.70  ? 600  GLY A N   1 
ATOM   2313 C  CA  . GLY A 1 337 ? -15.301 -23.287 -14.447 1.00 68.69  ? 600  GLY A CA  1 
ATOM   2314 C  C   . GLY A 1 337 ? -16.553 -23.077 -15.266 1.00 74.72  ? 600  GLY A C   1 
ATOM   2315 O  O   . GLY A 1 337 ? -16.733 -21.961 -15.816 1.00 77.21  ? 600  GLY A O   1 
ATOM   2316 N  N   . SER A 1 338 ? -17.312 -24.152 -15.440 1.00 69.29  ? 601  SER A N   1 
ATOM   2317 C  CA  . SER A 1 338 ? -18.557 -24.214 -16.236 1.00 58.84  ? 601  SER A CA  1 
ATOM   2318 C  C   . SER A 1 338 ? -19.250 -25.510 -15.825 1.00 61.07  ? 601  SER A C   1 
ATOM   2319 O  O   . SER A 1 338 ? -18.666 -26.253 -15.025 1.00 62.74  ? 601  SER A O   1 
ATOM   2320 C  CB  . SER A 1 338 ? -18.285 -24.170 -17.737 1.00 61.40  ? 601  SER A CB  1 
ATOM   2321 O  OG  . SER A 1 338 ? -17.231 -23.278 -18.079 1.00 57.41  ? 601  SER A OG  1 
ATOM   2322 N  N   . GLY A 1 339 ? -20.443 -25.771 -16.352 1.00 64.83  ? 602  GLY A N   1 
ATOM   2323 C  CA  . GLY A 1 339 ? -21.047 -27.115 -16.315 1.00 67.79  ? 602  GLY A CA  1 
ATOM   2324 C  C   . GLY A 1 339 ? -20.144 -28.132 -16.992 1.00 61.35  ? 602  GLY A C   1 
ATOM   2325 O  O   . GLY A 1 339 ? -19.405 -27.785 -17.945 1.00 45.82  ? 602  GLY A O   1 
ATOM   2326 N  N   . GLN A 1 340 ? -20.173 -29.359 -16.501 1.00 59.61  ? 603  GLN A N   1 
ATOM   2327 C  CA  . GLN A 1 340 ? -19.274 -30.407 -17.013 1.00 66.60  ? 603  GLN A CA  1 
ATOM   2328 C  C   . GLN A 1 340 ? -19.457 -30.457 -18.538 1.00 57.76  ? 603  GLN A C   1 
ATOM   2329 O  O   . GLN A 1 340 ? -18.457 -30.666 -19.232 1.00 58.91  ? 603  GLN A O   1 
ATOM   2330 C  CB  . GLN A 1 340 ? -19.527 -31.703 -16.242 1.00 75.89  ? 603  GLN A CB  1 
ATOM   2331 C  CG  . GLN A 1 340 ? -20.918 -32.273 -16.472 1.00 94.00  ? 603  GLN A CG  1 
ATOM   2332 C  CD  . GLN A 1 340 ? -21.316 -33.288 -15.429 1.00 99.93  ? 603  GLN A CD  1 
ATOM   2333 O  OE1 . GLN A 1 340 ? -22.320 -33.126 -14.737 1.00 115.78 ? 603  GLN A OE1 1 
ATOM   2334 N  NE2 . GLN A 1 340 ? -20.530 -34.346 -15.317 1.00 96.37  ? 603  GLN A NE2 1 
ATOM   2335 N  N   . VAL A 1 341 ? -20.657 -30.202 -19.065 1.00 51.18  ? 604  VAL A N   1 
ATOM   2336 C  CA  . VAL A 1 341 ? -20.931 -30.449 -20.513 1.00 47.99  ? 604  VAL A CA  1 
ATOM   2337 C  C   . VAL A 1 341 ? -20.424 -29.279 -21.363 1.00 50.18  ? 604  VAL A C   1 
ATOM   2338 O  O   . VAL A 1 341 ? -19.961 -29.521 -22.509 1.00 41.09  ? 604  VAL A O   1 
ATOM   2339 C  CB  . VAL A 1 341 ? -22.410 -30.726 -20.821 1.00 51.28  ? 604  VAL A CB  1 
ATOM   2340 C  CG1 . VAL A 1 341 ? -22.562 -31.012 -22.309 1.00 53.09  ? 604  VAL A CG1 1 
ATOM   2341 C  CG2 . VAL A 1 341 ? -22.990 -31.865 -19.979 1.00 47.63  ? 604  VAL A CG2 1 
ATOM   2342 N  N   . VAL A 1 342 ? -20.520 -28.041 -20.881 1.00 43.28  ? 605  VAL A N   1 
ATOM   2343 C  CA  . VAL A 1 342 ? -19.917 -26.922 -21.659 1.00 44.71  ? 605  VAL A CA  1 
ATOM   2344 C  C   . VAL A 1 342 ? -18.385 -26.986 -21.508 1.00 39.68  ? 605  VAL A C   1 
ATOM   2345 O  O   . VAL A 1 342 ? -17.669 -26.673 -22.450 1.00 40.96  ? 605  VAL A O   1 
ATOM   2346 C  CB  . VAL A 1 342 ? -20.544 -25.580 -21.247 1.00 47.53  ? 605  VAL A CB  1 
ATOM   2347 C  CG1 . VAL A 1 342 ? -19.713 -24.385 -21.680 1.00 50.86  ? 605  VAL A CG1 1 
ATOM   2348 C  CG2 . VAL A 1 342 ? -21.950 -25.485 -21.808 1.00 49.86  ? 605  VAL A CG2 1 
ATOM   2349 N  N   . THR A 1 343 ? -17.893 -27.410 -20.358 1.00 36.05  ? 606  THR A N   1 
ATOM   2350 C  CA  . THR A 1 343 ? -16.456 -27.676 -20.137 1.00 38.34  ? 606  THR A CA  1 
ATOM   2351 C  C   . THR A 1 343 ? -15.924 -28.626 -21.224 1.00 33.87  ? 606  THR A C   1 
ATOM   2352 O  O   . THR A 1 343 ? -14.866 -28.334 -21.803 1.00 40.35  ? 606  THR A O   1 
ATOM   2353 C  CB  . THR A 1 343 ? -16.257 -28.214 -18.720 1.00 37.86  ? 606  THR A CB  1 
ATOM   2354 O  OG1 . THR A 1 343 ? -16.685 -27.163 -17.859 1.00 43.80  ? 606  THR A OG1 1 
ATOM   2355 C  CG2 . THR A 1 343 ? -14.825 -28.585 -18.428 1.00 38.44  ? 606  THR A CG2 1 
ATOM   2356 N  N   . TYR A 1 344 ? -16.638 -29.711 -21.490 1.00 31.44  ? 607  TYR A N   1 
ATOM   2357 C  CA  . TYR A 1 344 ? -16.232 -30.740 -22.468 1.00 29.62  ? 607  TYR A CA  1 
ATOM   2358 C  C   . TYR A 1 344 ? -16.079 -30.079 -23.838 1.00 29.36  ? 607  TYR A C   1 
ATOM   2359 O  O   . TYR A 1 344 ? -15.053 -30.278 -24.484 1.00 33.31  ? 607  TYR A O   1 
ATOM   2360 C  CB  . TYR A 1 344 ? -17.228 -31.898 -22.491 1.00 29.61  ? 607  TYR A CB  1 
ATOM   2361 C  CG  . TYR A 1 344 ? -16.890 -32.922 -23.546 1.00 29.88  ? 607  TYR A CG  1 
ATOM   2362 C  CD1 . TYR A 1 344 ? -15.989 -33.929 -23.270 1.00 28.63  ? 607  TYR A CD1 1 
ATOM   2363 C  CD2 . TYR A 1 344 ? -17.368 -32.816 -24.843 1.00 28.77  ? 607  TYR A CD2 1 
ATOM   2364 C  CE1 . TYR A 1 344 ? -15.633 -34.854 -24.235 1.00 30.17  ? 607  TYR A CE1 1 
ATOM   2365 C  CE2 . TYR A 1 344 ? -17.027 -33.742 -25.816 1.00 30.88  ? 607  TYR A CE2 1 
ATOM   2366 C  CZ  . TYR A 1 344 ? -16.137 -34.756 -25.515 1.00 29.86  ? 607  TYR A CZ  1 
ATOM   2367 O  OH  . TYR A 1 344 ? -15.743 -35.672 -26.441 1.00 33.34  ? 607  TYR A OH  1 
ATOM   2368 N  N   . GLY A 1 345 ? -17.082 -29.329 -24.292 1.00 28.99  ? 608  GLY A N   1 
ATOM   2369 C  CA  . GLY A 1 345 ? -17.066 -28.730 -25.646 1.00 27.92  ? 608  GLY A CA  1 
ATOM   2370 C  C   . GLY A 1 345 ? -15.975 -27.684 -25.801 1.00 28.76  ? 608  GLY A C   1 
ATOM   2371 O  O   . GLY A 1 345 ? -15.315 -27.697 -26.827 1.00 36.38  ? 608  GLY A O   1 
ATOM   2372 N  N   . LEU A 1 346 ? -15.760 -26.826 -24.800 1.00 27.65  ? 609  LEU A N   1 
ATOM   2373 C  CA  . LEU A 1 346 ? -14.760 -25.726 -24.866 1.00 32.44  ? 609  LEU A CA  1 
ATOM   2374 C  C   . LEU A 1 346 ? -13.343 -26.290 -24.669 1.00 30.72  ? 609  LEU A C   1 
ATOM   2375 O  O   . LEU A 1 346 ? -12.423 -25.827 -25.376 1.00 32.68  ? 609  LEU A O   1 
ATOM   2376 C  CB  . LEU A 1 346 ? -15.111 -24.634 -23.828 1.00 32.34  ? 609  LEU A CB  1 
ATOM   2377 C  CG  . LEU A 1 346 ? -16.443 -23.911 -24.045 1.00 33.67  ? 609  LEU A CG  1 
ATOM   2378 C  CD1 . LEU A 1 346 ? -16.710 -22.892 -22.934 1.00 37.61  ? 609  LEU A CD1 1 
ATOM   2379 C  CD2 . LEU A 1 346 ? -16.488 -23.243 -25.410 1.00 33.25  ? 609  LEU A CD2 1 
ATOM   2380 N  N   . ASN A 1 347 ? -13.189 -27.287 -23.793 1.00 30.46  ? 610  ASN A N   1 
ATOM   2381 C  CA  . ASN A 1 347 ? -11.954 -28.118 -23.709 1.00 30.37  ? 610  ASN A CA  1 
ATOM   2382 C  C   . ASN A 1 347 ? -11.625 -28.713 -25.094 1.00 27.33  ? 610  ASN A C   1 
ATOM   2383 O  O   . ASN A 1 347 ? -10.545 -28.461 -25.577 1.00 28.22  ? 610  ASN A O   1 
ATOM   2384 C  CB  . ASN A 1 347 ? -12.079 -29.158 -22.597 1.00 28.13  ? 610  ASN A CB  1 
ATOM   2385 C  CG  . ASN A 1 347 ? -11.909 -28.525 -21.236 1.00 31.58  ? 610  ASN A CG  1 
ATOM   2386 O  OD1 . ASN A 1 347 ? -11.557 -27.361 -21.107 1.00 32.08  ? 610  ASN A OD1 1 
ATOM   2387 N  ND2 . ASN A 1 347 ? -12.131 -29.289 -20.195 1.00 39.21  ? 610  ASN A ND2 1 
ATOM   2388 N  N   . THR A 1 348 ? -12.546 -29.399 -25.761 1.00 26.82  ? 611  THR A N   1 
ATOM   2389 C  CA  . THR A 1 348 ? -12.291 -29.970 -27.109 1.00 29.01  ? 611  THR A CA  1 
ATOM   2390 C  C   . THR A 1 348 ? -11.827 -28.852 -28.063 1.00 32.96  ? 611  THR A C   1 
ATOM   2391 O  O   . THR A 1 348 ? -10.811 -29.062 -28.797 1.00 30.13  ? 611  THR A O   1 
ATOM   2392 C  CB  . THR A 1 348 ? -13.532 -30.683 -27.629 1.00 27.99  ? 611  THR A CB  1 
ATOM   2393 O  OG1 . THR A 1 348 ? -13.974 -31.607 -26.626 1.00 28.43  ? 611  THR A OG1 1 
ATOM   2394 C  CG2 . THR A 1 348 ? -13.277 -31.347 -28.953 1.00 26.94  ? 611  THR A CG2 1 
ATOM   2395 N  N   . PHE A 1 349 ? -12.513 -27.703 -28.048 1.00 32.85  ? 612  PHE A N   1 
ATOM   2396 C  CA  . PHE A 1 349 ? -12.249 -26.574 -28.982 1.00 33.49  ? 612  PHE A CA  1 
ATOM   2397 C  C   . PHE A 1 349 ? -10.810 -26.084 -28.775 1.00 34.76  ? 612  PHE A C   1 
ATOM   2398 O  O   . PHE A 1 349 ? -10.033 -25.971 -29.747 1.00 31.55  ? 612  PHE A O   1 
ATOM   2399 C  CB  . PHE A 1 349 ? -13.195 -25.398 -28.728 1.00 34.12  ? 612  PHE A CB  1 
ATOM   2400 C  CG  . PHE A 1 349 ? -12.942 -24.218 -29.630 1.00 31.29  ? 612  PHE A CG  1 
ATOM   2401 C  CD1 . PHE A 1 349 ? -13.463 -24.191 -30.913 1.00 32.97  ? 612  PHE A CD1 1 
ATOM   2402 C  CD2 . PHE A 1 349 ? -12.178 -23.147 -29.203 1.00 31.08  ? 612  PHE A CD2 1 
ATOM   2403 C  CE1 . PHE A 1 349 ? -13.211 -23.127 -31.770 1.00 33.39  ? 612  PHE A CE1 1 
ATOM   2404 C  CE2 . PHE A 1 349 ? -11.907 -22.086 -30.059 1.00 33.43  ? 612  PHE A CE2 1 
ATOM   2405 C  CZ  . PHE A 1 349 ? -12.409 -22.082 -31.348 1.00 33.76  ? 612  PHE A CZ  1 
ATOM   2406 N  N   . THR A 1 350 ? -10.481 -25.749 -27.534 1.00 31.20  ? 613  THR A N   1 
ATOM   2407 C  CA  . THR A 1 350 ? -9.177  -25.144 -27.179 1.00 35.51  ? 613  THR A CA  1 
ATOM   2408 C  C   . THR A 1 350 ? -8.055  -26.180 -27.408 1.00 34.95  ? 613  THR A C   1 
ATOM   2409 O  O   . THR A 1 350 ? -7.014  -25.795 -27.941 1.00 36.60  ? 613  THR A O   1 
ATOM   2410 C  CB  . THR A 1 350 ? -9.227  -24.580 -25.756 1.00 36.64  ? 613  THR A CB  1 
ATOM   2411 O  OG1 . THR A 1 350 ? -10.260 -23.593 -25.733 1.00 34.04  ? 613  THR A OG1 1 
ATOM   2412 C  CG2 . THR A 1 350 ? -7.910  -23.959 -25.326 1.00 38.26  ? 613  THR A CG2 1 
ATOM   2413 N  N   . ASN A 1 351 ? -8.296  -27.456 -27.081 1.00 33.91  ? 614  ASN A N   1 
ATOM   2414 C  CA  . ASN A 1 351 ? -7.374  -28.584 -27.372 1.00 34.00  ? 614  ASN A CA  1 
ATOM   2415 C  C   . ASN A 1 351 ? -7.199  -28.731 -28.889 1.00 31.09  ? 614  ASN A C   1 
ATOM   2416 O  O   . ASN A 1 351 ? -6.072  -28.915 -29.341 1.00 31.21  ? 614  ASN A O   1 
ATOM   2417 C  CB  . ASN A 1 351 ? -7.825  -29.892 -26.707 1.00 30.92  ? 614  ASN A CB  1 
ATOM   2418 C  CG  . ASN A 1 351 ? -6.668  -30.838 -26.433 1.00 35.19  ? 614  ASN A CG  1 
ATOM   2419 O  OD1 . ASN A 1 351 ? -5.503  -30.495 -26.698 1.00 31.68  ? 614  ASN A OD1 1 
ATOM   2420 N  ND2 . ASN A 1 351 ? -6.973  -32.018 -25.889 1.00 32.02  ? 614  ASN A ND2 1 
ATOM   2421 N  N   . MET A 1 352 ? -8.262  -28.678 -29.662 1.00 28.64  ? 615  MET A N   1 
ATOM   2422 C  CA  . MET A 1 352 ? -8.123  -28.706 -31.148 1.00 33.06  ? 615  MET A CA  1 
ATOM   2423 C  C   . MET A 1 352 ? -7.175  -27.578 -31.598 1.00 32.64  ? 615  MET A C   1 
ATOM   2424 O  O   . MET A 1 352 ? -6.319  -27.833 -32.467 1.00 35.69  ? 615  MET A O   1 
ATOM   2425 C  CB  . MET A 1 352 ? -9.472  -28.550 -31.858 1.00 30.84  ? 615  MET A CB  1 
ATOM   2426 C  CG  . MET A 1 352 ? -10.287 -29.801 -31.882 1.00 32.80  ? 615  MET A CG  1 
ATOM   2427 S  SD  . MET A 1 352 ? -11.998 -29.557 -32.434 1.00 35.70  ? 615  MET A SD  1 
ATOM   2428 C  CE  . MET A 1 352 ? -11.772 -29.207 -34.166 1.00 31.63  ? 615  MET A CE  1 
ATOM   2429 N  N   . GLU A 1 353 ? -7.301  -26.390 -31.011 1.00 34.16  ? 616  GLU A N   1 
ATOM   2430 C  CA  . GLU A 1 353 ? -6.556  -25.154 -31.386 1.00 33.56  ? 616  GLU A CA  1 
ATOM   2431 C  C   . GLU A 1 353 ? -5.063  -25.343 -31.025 1.00 33.59  ? 616  GLU A C   1 
ATOM   2432 O  O   . GLU A 1 353 ? -4.150  -25.163 -31.892 1.00 28.84  ? 616  GLU A O   1 
ATOM   2433 C  CB  . GLU A 1 353 ? -7.234  -23.994 -30.641 1.00 34.37  ? 616  GLU A CB  1 
ATOM   2434 C  CG  . GLU A 1 353 ? -6.645  -22.599 -30.888 1.00 38.01  ? 616  GLU A CG  1 
ATOM   2435 C  CD  . GLU A 1 353 ? -6.969  -21.629 -29.753 1.00 38.14  ? 616  GLU A CD  1 
ATOM   2436 O  OE1 . GLU A 1 353 ? -8.191  -21.272 -29.580 1.00 39.47  ? 616  GLU A OE1 1 
ATOM   2437 O  OE2 . GLU A 1 353 ? -6.032  -21.305 -28.976 1.00 33.06  ? 616  GLU A OE2 1 
ATOM   2438 N  N   . ALA A 1 354 ? -4.793  -25.728 -29.780 1.00 30.87  ? 617  ALA A N   1 
ATOM   2439 C  CA  . ALA A 1 354 ? -3.421  -26.001 -29.299 1.00 29.54  ? 617  ALA A CA  1 
ATOM   2440 C  C   . ALA A 1 354 ? -2.726  -27.036 -30.196 1.00 32.29  ? 617  ALA A C   1 
ATOM   2441 O  O   . ALA A 1 354 ? -1.563  -26.815 -30.563 1.00 30.13  ? 617  ALA A O   1 
ATOM   2442 C  CB  . ALA A 1 354 ? -3.502  -26.447 -27.884 1.00 30.70  ? 617  ALA A CB  1 
ATOM   2443 N  N   . GLN A 1 355 ? -3.412  -28.127 -30.564 1.00 31.80  ? 618  GLN A N   1 
ATOM   2444 C  CA  . GLN A 1 355 ? -2.792  -29.208 -31.363 1.00 30.40  ? 618  GLN A CA  1 
ATOM   2445 C  C   . GLN A 1 355 ? -2.587  -28.775 -32.830 1.00 30.25  ? 618  GLN A C   1 
ATOM   2446 O  O   . GLN A 1 355 ? -1.592  -29.237 -33.443 1.00 32.38  ? 618  GLN A O   1 
ATOM   2447 C  CB  . GLN A 1 355 ? -3.582  -30.510 -31.236 1.00 30.46  ? 618  GLN A CB  1 
ATOM   2448 C  CG  . GLN A 1 355 ? -3.765  -31.000 -29.808 1.00 31.15  ? 618  GLN A CG  1 
ATOM   2449 C  CD  . GLN A 1 355 ? -2.463  -31.212 -29.095 1.00 31.75  ? 618  GLN A CD  1 
ATOM   2450 O  OE1 . GLN A 1 355 ? -1.507  -31.752 -29.628 1.00 31.48  ? 618  GLN A OE1 1 
ATOM   2451 N  NE2 . GLN A 1 355 ? -2.423  -30.793 -27.857 1.00 35.04  ? 618  GLN A NE2 1 
ATOM   2452 N  N   . LEU A 1 356 ? -3.448  -27.953 -33.426 1.00 28.85  ? 619  LEU A N   1 
ATOM   2453 C  CA  . LEU A 1 356 ? -3.180  -27.424 -34.802 1.00 31.21  ? 619  LEU A CA  1 
ATOM   2454 C  C   . LEU A 1 356 ? -1.897  -26.582 -34.765 1.00 31.97  ? 619  LEU A C   1 
ATOM   2455 O  O   . LEU A 1 356 ? -1.139  -26.637 -35.736 1.00 32.93  ? 619  LEU A O   1 
ATOM   2456 C  CB  . LEU A 1 356 ? -4.316  -26.528 -35.296 1.00 32.55  ? 619  LEU A CB  1 
ATOM   2457 C  CG  . LEU A 1 356 ? -5.443  -27.213 -36.052 1.00 37.45  ? 619  LEU A CG  1 
ATOM   2458 C  CD1 . LEU A 1 356 ? -6.491  -26.193 -36.437 1.00 37.53  ? 619  LEU A CD1 1 
ATOM   2459 C  CD2 . LEU A 1 356 ? -4.943  -27.945 -37.288 1.00 37.12  ? 619  LEU A CD2 1 
ATOM   2460 N  N   . ILE A 1 357 ? -1.702  -25.804 -33.694 1.00 30.22  ? 620  ILE A N   1 
ATOM   2461 C  CA  . ILE A 1 357 ? -0.569  -24.853 -33.546 1.00 32.55  ? 620  ILE A CA  1 
ATOM   2462 C  C   . ILE A 1 357 ? 0.728   -25.647 -33.333 1.00 36.32  ? 620  ILE A C   1 
ATOM   2463 O  O   . ILE A 1 357 ? 1.739   -25.256 -33.923 1.00 33.47  ? 620  ILE A O   1 
ATOM   2464 C  CB  . ILE A 1 357 ? -0.832  -23.840 -32.421 1.00 36.21  ? 620  ILE A CB  1 
ATOM   2465 C  CG1 . ILE A 1 357 ? -1.910  -22.830 -32.833 1.00 39.58  ? 620  ILE A CG1 1 
ATOM   2466 C  CG2 . ILE A 1 357 ? 0.469   -23.146 -31.995 1.00 37.84  ? 620  ILE A CG2 1 
ATOM   2467 C  CD1 . ILE A 1 357 ? -2.527  -22.058 -31.675 1.00 40.79  ? 620  ILE A CD1 1 
ATOM   2468 N  N   . ARG A 1 358 ? 0.707   -26.679 -32.482 1.00 34.99  ? 621  ARG A N   1 
ATOM   2469 C  CA  . ARG A 1 358 ? 1.860   -27.572 -32.287 1.00 31.59  ? 621  ARG A CA  1 
ATOM   2470 C  C   . ARG A 1 358 ? 2.215   -28.233 -33.619 1.00 33.70  ? 621  ARG A C   1 
ATOM   2471 O  O   . ARG A 1 358 ? 3.415   -28.414 -33.875 1.00 35.03  ? 621  ARG A O   1 
ATOM   2472 C  CB  . ARG A 1 358 ? 1.577   -28.647 -31.246 1.00 32.02  ? 621  ARG A CB  1 
ATOM   2473 C  CG  . ARG A 1 358 ? 2.791   -29.537 -31.010 1.00 30.18  ? 621  ARG A CG  1 
ATOM   2474 C  CD  . ARG A 1 358 ? 2.699   -30.418 -29.780 1.00 31.59  ? 621  ARG A CD  1 
ATOM   2475 N  NE  . ARG A 1 358 ? 3.890   -31.275 -29.697 1.00 32.27  ? 621  ARG A NE  1 
ATOM   2476 C  CZ  . ARG A 1 358 ? 4.059   -32.279 -28.845 1.00 31.56  ? 621  ARG A CZ  1 
ATOM   2477 N  NH1 . ARG A 1 358 ? 3.092   -32.619 -28.018 1.00 28.81  ? 621  ARG A NH1 1 
ATOM   2478 N  NH2 . ARG A 1 358 ? 5.186   -32.975 -28.858 1.00 37.19  ? 621  ARG A NH2 1 
ATOM   2479 N  N   . GLN A 1 359 ? 1.227   -28.640 -34.407 1.00 32.03  ? 622  GLN A N   1 
ATOM   2480 C  CA  . GLN A 1 359 ? 1.467   -29.198 -35.753 1.00 34.84  ? 622  GLN A CA  1 
ATOM   2481 C  C   . GLN A 1 359 ? 2.106   -28.090 -36.622 1.00 41.94  ? 622  GLN A C   1 
ATOM   2482 O  O   . GLN A 1 359 ? 2.959   -28.419 -37.491 1.00 53.82  ? 622  GLN A O   1 
ATOM   2483 C  CB  . GLN A 1 359 ? 0.177   -29.710 -36.411 1.00 33.73  ? 622  GLN A CB  1 
ATOM   2484 C  CG  . GLN A 1 359 ? -0.338  -31.050 -35.924 1.00 32.13  ? 622  GLN A CG  1 
ATOM   2485 C  CD  . GLN A 1 359 ? -1.339  -31.689 -36.873 1.00 34.43  ? 622  GLN A CD  1 
ATOM   2486 O  OE1 . GLN A 1 359 ? -1.015  -32.250 -37.929 1.00 34.25  ? 622  GLN A OE1 1 
ATOM   2487 N  NE2 . GLN A 1 359 ? -2.597  -31.634 -36.493 1.00 34.30  ? 622  GLN A NE2 1 
ATOM   2488 N  N   . MET A 1 360 ? 1.682   -26.836 -36.479 1.00 40.64  ? 623  MET A N   1 
ATOM   2489 C  CA  . MET A 1 360 ? 2.231   -25.698 -37.286 1.00 46.94  ? 623  MET A CA  1 
ATOM   2490 C  C   . MET A 1 360 ? 3.741   -25.569 -36.983 1.00 45.38  ? 623  MET A C   1 
ATOM   2491 O  O   . MET A 1 360 ? 4.530   -25.501 -37.935 1.00 40.76  ? 623  MET A O   1 
ATOM   2492 C  CB  . MET A 1 360 ? 1.534   -24.370 -36.961 1.00 43.72  ? 623  MET A CB  1 
ATOM   2493 C  CG  . MET A 1 360 ? 0.353   -24.012 -37.866 1.00 46.49  ? 623  MET A CG  1 
ATOM   2494 S  SD  . MET A 1 360 ? -0.514  -22.644 -37.089 1.00 42.73  ? 623  MET A SD  1 
ATOM   2495 C  CE  . MET A 1 360 ? -2.231  -23.081 -37.359 1.00 45.62  ? 623  MET A CE  1 
ATOM   2496 N  N   . GLU A 1 361 ? 4.102   -25.593 -35.700 1.00 37.51  ? 624  GLU A N   1 
ATOM   2497 C  CA  . GLU A 1 361 ? 5.492   -25.484 -35.202 1.00 39.56  ? 624  GLU A CA  1 
ATOM   2498 C  C   . GLU A 1 361 ? 6.313   -26.652 -35.742 1.00 41.88  ? 624  GLU A C   1 
ATOM   2499 O  O   . GLU A 1 361 ? 7.407   -26.408 -36.180 1.00 43.47  ? 624  GLU A O   1 
ATOM   2500 C  CB  . GLU A 1 361 ? 5.498   -25.448 -33.676 1.00 36.66  ? 624  GLU A CB  1 
ATOM   2501 C  CG  . GLU A 1 361 ? 6.853   -25.172 -33.076 1.00 38.37  ? 624  GLU A CG  1 
ATOM   2502 C  CD  . GLU A 1 361 ? 6.830   -24.812 -31.591 1.00 43.03  ? 624  GLU A CD  1 
ATOM   2503 O  OE1 . GLU A 1 361 ? 7.899   -24.876 -30.946 1.00 40.41  ? 624  GLU A OE1 1 
ATOM   2504 O  OE2 . GLU A 1 361 ? 5.738   -24.463 -31.066 1.00 40.90  ? 624  GLU A OE2 1 
ATOM   2505 N  N   . GLY A 1 362 ? 5.819   -27.883 -35.698 1.00 39.24  ? 625  GLY A N   1 
ATOM   2506 C  CA  . GLY A 1 362 ? 6.561   -29.018 -36.284 1.00 46.89  ? 625  GLY A CA  1 
ATOM   2507 C  C   . GLY A 1 362 ? 6.817   -28.855 -37.788 1.00 44.63  ? 625  GLY A C   1 
ATOM   2508 O  O   . GLY A 1 362 ? 7.829   -29.392 -38.297 1.00 40.82  ? 625  GLY A O   1 
ATOM   2509 N  N   . GLU A 1 363 ? 5.891   -28.236 -38.509 1.00 36.42  ? 626  GLU A N   1 
ATOM   2510 C  CA  . GLU A 1 363 ? 5.989   -28.077 -39.978 1.00 42.45  ? 626  GLU A CA  1 
ATOM   2511 C  C   . GLU A 1 363 ? 6.779   -26.793 -40.308 1.00 39.61  ? 626  GLU A C   1 
ATOM   2512 O  O   . GLU A 1 363 ? 6.994   -26.517 -41.481 1.00 39.61  ? 626  GLU A O   1 
ATOM   2513 C  CB  . GLU A 1 363 ? 4.582   -28.113 -40.578 1.00 41.22  ? 626  GLU A CB  1 
ATOM   2514 C  CG  . GLU A 1 363 ? 3.993   -29.524 -40.579 1.00 41.41  ? 626  GLU A CG  1 
ATOM   2515 C  CD  . GLU A 1 363 ? 2.592   -29.627 -41.176 1.00 44.23  ? 626  GLU A CD  1 
ATOM   2516 O  OE1 . GLU A 1 363 ? 2.402   -29.145 -42.291 1.00 41.94  ? 626  GLU A OE1 1 
ATOM   2517 O  OE2 . GLU A 1 363 ? 1.679   -30.152 -40.510 1.00 45.48  ? 626  GLU A OE2 1 
ATOM   2518 N  N   . GLY A 1 364 ? 7.219   -26.044 -39.302 1.00 38.20  ? 627  GLY A N   1 
ATOM   2519 C  CA  . GLY A 1 364 ? 7.926   -24.764 -39.477 1.00 46.18  ? 627  GLY A CA  1 
ATOM   2520 C  C   . GLY A 1 364 ? 7.091   -23.740 -40.228 1.00 57.25  ? 627  GLY A C   1 
ATOM   2521 O  O   . GLY A 1 364 ? 7.656   -23.082 -41.129 1.00 57.96  ? 627  GLY A O   1 
ATOM   2522 N  N   . VAL A 1 365 ? 5.799   -23.604 -39.884 1.00 52.60  ? 628  VAL A N   1 
ATOM   2523 C  CA  . VAL A 1 365 ? 4.913   -22.553 -40.452 1.00 47.76  ? 628  VAL A CA  1 
ATOM   2524 C  C   . VAL A 1 365 ? 5.353   -21.208 -39.868 1.00 52.62  ? 628  VAL A C   1 
ATOM   2525 O  O   . VAL A 1 365 ? 5.262   -20.201 -40.594 1.00 56.30  ? 628  VAL A O   1 
ATOM   2526 C  CB  . VAL A 1 365 ? 3.428   -22.855 -40.194 1.00 49.61  ? 628  VAL A CB  1 
ATOM   2527 C  CG1 . VAL A 1 365 ? 2.536   -21.702 -40.615 1.00 52.13  ? 628  VAL A CG1 1 
ATOM   2528 C  CG2 . VAL A 1 365 ? 2.996   -24.121 -40.912 1.00 51.02  ? 628  VAL A CG2 1 
ATOM   2529 N  N   . PHE A 1 366 ? 5.804   -21.205 -38.610 1.00 48.19  ? 629  PHE A N   1 
ATOM   2530 C  CA  . PHE A 1 366 ? 6.384   -20.038 -37.906 1.00 51.40  ? 629  PHE A CA  1 
ATOM   2531 C  C   . PHE A 1 366 ? 7.670   -20.455 -37.170 1.00 59.68  ? 629  PHE A C   1 
ATOM   2532 O  O   . PHE A 1 366 ? 7.843   -21.635 -36.829 1.00 65.90  ? 629  PHE A O   1 
ATOM   2533 C  CB  . PHE A 1 366 ? 5.359   -19.445 -36.945 1.00 48.00  ? 629  PHE A CB  1 
ATOM   2534 C  CG  . PHE A 1 366 ? 5.099   -20.294 -35.734 1.00 46.08  ? 629  PHE A CG  1 
ATOM   2535 C  CD1 . PHE A 1 366 ? 4.059   -21.209 -35.723 1.00 49.91  ? 629  PHE A CD1 1 
ATOM   2536 C  CD2 . PHE A 1 366 ? 5.893   -20.178 -34.607 1.00 47.12  ? 629  PHE A CD2 1 
ATOM   2537 C  CE1 . PHE A 1 366 ? 3.803   -21.981 -34.600 1.00 46.48  ? 629  PHE A CE1 1 
ATOM   2538 C  CE2 . PHE A 1 366 ? 5.641   -20.956 -33.488 1.00 50.13  ? 629  PHE A CE2 1 
ATOM   2539 C  CZ  . PHE A 1 366 ? 4.602   -21.864 -33.492 1.00 50.78  ? 629  PHE A CZ  1 
ATOM   2540 N  N   . LYS A 1 367 ? 8.565   -19.488 -36.928 0.26 57.28  ? 630  LYS A N   1 
ATOM   2541 C  CA  . LYS A 1 367 ? 9.896   -19.714 -36.297 0.26 55.88  ? 630  LYS A CA  1 
ATOM   2542 C  C   . LYS A 1 367 ? 9.815   -19.403 -34.798 0.26 55.43  ? 630  LYS A C   1 
ATOM   2543 O  O   . LYS A 1 367 ? 10.088  -20.312 -33.992 0.26 55.74  ? 630  LYS A O   1 
ATOM   2544 C  CB  . LYS A 1 367 ? 10.975  -18.848 -36.957 0.26 55.66  ? 630  LYS A CB  1 
ATOM   2545 C  CG  . LYS A 1 367 ? 12.409  -19.211 -36.583 0.26 55.11  ? 630  LYS A CG  1 
ATOM   2546 C  CD  . LYS A 1 367 ? 13.443  -18.139 -36.904 0.26 54.08  ? 630  LYS A CD  1 
ATOM   2547 C  CE  . LYS A 1 367 ? 13.835  -17.279 -35.717 0.26 52.63  ? 630  LYS A CE  1 
ATOM   2548 N  NZ  . LYS A 1 367 ? 12.864  -16.186 -35.471 0.26 51.73  ? 630  LYS A NZ  1 
ATOM   2549 N  N   . SER A 1 368 ? 9.466   -18.160 -34.453 0.26 54.77  ? 631  SER A N   1 
ATOM   2550 C  CA  . SER A 1 368 ? 9.501   -17.609 -33.074 0.26 54.53  ? 631  SER A CA  1 
ATOM   2551 C  C   . SER A 1 368 ? 8.078   -17.402 -32.552 0.26 54.88  ? 631  SER A C   1 
ATOM   2552 O  O   . SER A 1 368 ? 7.233   -16.914 -33.324 0.26 56.71  ? 631  SER A O   1 
ATOM   2553 C  CB  . SER A 1 368 ? 10.282  -16.318 -33.026 0.26 55.21  ? 631  SER A CB  1 
ATOM   2554 O  OG  . SER A 1 368 ? 9.837   -15.488 -31.960 0.26 54.38  ? 631  SER A OG  1 
ATOM   2555 N  N   . ILE A 1 369 ? 7.851   -17.740 -31.280 0.26 54.95  ? 632  ILE A N   1 
ATOM   2556 C  CA  . ILE A 1 369 ? 6.590   -17.452 -30.533 0.26 57.14  ? 632  ILE A CA  1 
ATOM   2557 C  C   . ILE A 1 369 ? 6.704   -16.072 -29.876 0.26 59.03  ? 632  ILE A C   1 
ATOM   2558 O  O   . ILE A 1 369 ? 5.688   -15.615 -29.309 0.26 57.77  ? 632  ILE A O   1 
ATOM   2559 C  CB  . ILE A 1 369 ? 6.284   -18.552 -29.493 0.26 56.44  ? 632  ILE A CB  1 
ATOM   2560 C  CG1 . ILE A 1 369 ? 7.352   -18.638 -28.399 0.26 55.99  ? 632  ILE A CG1 1 
ATOM   2561 C  CG2 . ILE A 1 369 ? 6.069   -19.891 -30.179 0.26 56.99  ? 632  ILE A CG2 1 
ATOM   2562 C  CD1 . ILE A 1 369 ? 6.940   -19.466 -27.207 0.26 56.74  ? 632  ILE A CD1 1 
ATOM   2563 N  N   . GLN A 1 370 ? 7.886   -15.458 -29.919 1.00 60.81  ? 633  GLN A N   1 
ATOM   2564 C  CA  . GLN A 1 370 ? 8.098   -14.154 -29.240 1.00 64.95  ? 633  GLN A CA  1 
ATOM   2565 C  C   . GLN A 1 370 ? 7.302   -13.087 -29.981 1.00 68.26  ? 633  GLN A C   1 
ATOM   2566 O  O   . GLN A 1 370 ? 6.721   -12.221 -29.314 1.00 63.80  ? 633  GLN A O   1 
ATOM   2567 C  CB  . GLN A 1 370 ? 9.582   -13.798 -29.223 1.00 66.16  ? 633  GLN A CB  1 
ATOM   2568 C  CG  . GLN A 1 370 ? 10.018  -13.076 -27.957 1.00 72.21  ? 633  GLN A CG  1 
ATOM   2569 C  CD  . GLN A 1 370 ? 10.194  -14.018 -26.792 1.00 72.92  ? 633  GLN A CD  1 
ATOM   2570 O  OE1 . GLN A 1 370 ? 10.263  -15.232 -26.956 1.00 73.22  ? 633  GLN A OE1 1 
ATOM   2571 N  NE2 . GLN A 1 370 ? 10.277  -13.458 -25.596 1.00 77.23  ? 633  GLN A NE2 1 
ATOM   2572 N  N   . HIS A 1 371 ? 7.299   -13.162 -31.312 0.26 68.95  ? 634  HIS A N   1 
ATOM   2573 C  CA  . HIS A 1 371 ? 6.546   -12.189 -32.141 0.26 70.98  ? 634  HIS A CA  1 
ATOM   2574 C  C   . HIS A 1 371 ? 6.332   -12.799 -33.525 0.26 72.02  ? 634  HIS A C   1 
ATOM   2575 O  O   . HIS A 1 371 ? 7.229   -13.519 -34.000 0.26 71.52  ? 634  HIS A O   1 
ATOM   2576 C  CB  . HIS A 1 371 ? 7.289   -10.851 -32.217 0.26 72.77  ? 634  HIS A CB  1 
ATOM   2577 C  CG  . HIS A 1 371 ? 6.975   -10.067 -33.447 0.26 74.68  ? 634  HIS A CG  1 
ATOM   2578 N  ND1 . HIS A 1 371 ? 7.716   -10.189 -34.607 0.26 76.47  ? 634  HIS A ND1 1 
ATOM   2579 C  CD2 . HIS A 1 371 ? 6.007   -9.163  -33.708 0.26 74.61  ? 634  HIS A CD2 1 
ATOM   2580 C  CE1 . HIS A 1 371 ? 7.219   -9.389  -35.529 0.26 76.40  ? 634  HIS A CE1 1 
ATOM   2581 N  NE2 . HIS A 1 371 ? 6.170   -8.749  -35.002 0.26 75.29  ? 634  HIS A NE2 1 
ATOM   2582 N  N   . LEU A 1 372 ? 5.188   -12.510 -34.142 1.00 73.63  ? 635  LEU A N   1 
ATOM   2583 C  CA  . LEU A 1 372 ? 4.883   -13.069 -35.478 1.00 74.01  ? 635  LEU A CA  1 
ATOM   2584 C  C   . LEU A 1 372 ? 5.038   -11.970 -36.522 1.00 71.70  ? 635  LEU A C   1 
ATOM   2585 O  O   . LEU A 1 372 ? 4.500   -10.878 -36.307 1.00 77.15  ? 635  LEU A O   1 
ATOM   2586 C  CB  . LEU A 1 372 ? 3.458   -13.626 -35.481 1.00 79.80  ? 635  LEU A CB  1 
ATOM   2587 C  CG  . LEU A 1 372 ? 3.264   -14.941 -36.231 1.00 75.59  ? 635  LEU A CG  1 
ATOM   2588 C  CD1 . LEU A 1 372 ? 3.931   -16.082 -35.482 1.00 74.63  ? 635  LEU A CD1 1 
ATOM   2589 C  CD2 . LEU A 1 372 ? 1.785   -15.230 -36.432 1.00 70.46  ? 635  LEU A CD2 1 
ATOM   2590 N  N   . THR A 1 373 ? 5.748   -12.273 -37.603 1.00 67.30  ? 636  THR A N   1 
ATOM   2591 C  CA  . THR A 1 373 ? 5.935   -11.291 -38.687 1.00 67.24  ? 636  THR A CA  1 
ATOM   2592 C  C   . THR A 1 373 ? 4.611   -11.098 -39.408 1.00 66.72  ? 636  THR A C   1 
ATOM   2593 O  O   . THR A 1 373 ? 3.682   -11.865 -39.139 1.00 73.82  ? 636  THR A O   1 
ATOM   2594 C  CB  . THR A 1 373 ? 7.001   -11.775 -39.669 1.00 67.28  ? 636  THR A CB  1 
ATOM   2595 O  OG1 . THR A 1 373 ? 6.413   -12.748 -40.530 1.00 78.23  ? 636  THR A OG1 1 
ATOM   2596 C  CG2 . THR A 1 373 ? 8.207   -12.364 -38.970 1.00 64.64  ? 636  THR A CG2 1 
ATOM   2597 N  N   . VAL A 1 374 ? 4.551   -10.117 -40.299 1.00 71.88  ? 637  VAL A N   1 
ATOM   2598 C  CA  . VAL A 1 374 ? 3.317   -9.885  -41.110 1.00 79.29  ? 637  VAL A CA  1 
ATOM   2599 C  C   . VAL A 1 374 ? 3.181   -11.029 -42.115 1.00 80.89  ? 637  VAL A C   1 
ATOM   2600 O  O   . VAL A 1 374 ? 2.031   -11.476 -42.351 1.00 81.93  ? 637  VAL A O   1 
ATOM   2601 C  CB  . VAL A 1 374 ? 3.308   -8.520  -41.825 1.00 82.83  ? 637  VAL A CB  1 
ATOM   2602 C  CG1 . VAL A 1 374 ? 3.400   -7.381  -40.825 1.00 88.43  ? 637  VAL A CG1 1 
ATOM   2603 C  CG2 . VAL A 1 374 ? 4.392   -8.400  -42.894 1.00 84.65  ? 637  VAL A CG2 1 
ATOM   2604 N  N   . THR A 1 375 ? 4.306   -11.476 -42.678 1.00 73.30  ? 638  THR A N   1 
ATOM   2605 C  CA  . THR A 1 375 ? 4.360   -12.601 -43.647 1.00 81.35  ? 638  THR A CA  1 
ATOM   2606 C  C   . THR A 1 375 ? 4.062   -13.926 -42.920 1.00 84.00  ? 638  THR A C   1 
ATOM   2607 O  O   . THR A 1 375 ? 3.557   -14.853 -43.591 1.00 78.75  ? 638  THR A O   1 
ATOM   2608 C  CB  . THR A 1 375 ? 5.719   -12.653 -44.358 1.00 85.40  ? 638  THR A CB  1 
ATOM   2609 O  OG1 . THR A 1 375 ? 6.700   -12.794 -43.332 1.00 95.80  ? 638  THR A OG1 1 
ATOM   2610 C  CG2 . THR A 1 375 ? 6.012   -11.434 -45.208 1.00 85.13  ? 638  THR A CG2 1 
ATOM   2611 N  N   . GLU A 1 376 ? 4.382   -14.021 -41.617 1.00 80.67  ? 639  GLU A N   1 
ATOM   2612 C  CA  . GLU A 1 376 ? 4.123   -15.226 -40.779 1.00 71.64  ? 639  GLU A CA  1 
ATOM   2613 C  C   . GLU A 1 376 ? 2.608   -15.358 -40.569 1.00 62.74  ? 639  GLU A C   1 
ATOM   2614 O  O   . GLU A 1 376 ? 2.112   -16.456 -40.821 1.00 56.14  ? 639  GLU A O   1 
ATOM   2615 C  CB  . GLU A 1 376 ? 4.957   -15.238 -39.490 1.00 64.59  ? 639  GLU A CB  1 
ATOM   2616 C  CG  . GLU A 1 376 ? 6.258   -16.012 -39.665 1.00 61.06  ? 639  GLU A CG  1 
ATOM   2617 C  CD  . GLU A 1 376 ? 7.250   -16.044 -38.511 1.00 63.26  ? 639  GLU A CD  1 
ATOM   2618 O  OE1 . GLU A 1 376 ? 8.164   -16.881 -38.569 1.00 65.83  ? 639  GLU A OE1 1 
ATOM   2619 O  OE2 . GLU A 1 376 ? 7.134   -15.232 -37.569 1.00 65.26  ? 639  GLU A OE2 1 
ATOM   2620 N  N   . GLU A 1 377 ? 1.894   -14.279 -40.231 1.00 59.06  ? 640  GLU A N   1 
ATOM   2621 C  CA  . GLU A 1 377 ? 0.401   -14.266 -40.232 1.00 57.11  ? 640  GLU A CA  1 
ATOM   2622 C  C   . GLU A 1 377 ? -0.112  -14.753 -41.590 1.00 60.62  ? 640  GLU A C   1 
ATOM   2623 O  O   . GLU A 1 377 ? -1.015  -15.585 -41.598 1.00 67.96  ? 640  GLU A O   1 
ATOM   2624 C  CB  . GLU A 1 377 ? -0.185  -12.891 -39.935 1.00 56.83  ? 640  GLU A CB  1 
ATOM   2625 C  CG  . GLU A 1 377 ? 0.198   -12.382 -38.564 1.00 67.55  ? 640  GLU A CG  1 
ATOM   2626 C  CD  . GLU A 1 377 ? -0.576  -11.167 -38.093 1.00 71.81  ? 640  GLU A CD  1 
ATOM   2627 O  OE1 . GLU A 1 377 ? -1.767  -11.051 -38.458 1.00 77.37  ? 640  GLU A OE1 1 
ATOM   2628 O  OE2 . GLU A 1 377 ? 0.008   -10.355 -37.343 1.00 73.61  ? 640  GLU A OE2 1 
ATOM   2629 N  N   . ILE A 1 378 ? 0.446   -14.283 -42.704 1.00 63.69  ? 641  ILE A N   1 
ATOM   2630 C  CA  . ILE A 1 378 ? 0.012   -14.751 -44.059 1.00 68.03  ? 641  ILE A CA  1 
ATOM   2631 C  C   . ILE A 1 378 ? 0.248   -16.268 -44.137 1.00 57.85  ? 641  ILE A C   1 
ATOM   2632 O  O   . ILE A 1 378 ? -0.652  -16.980 -44.605 1.00 63.08  ? 641  ILE A O   1 
ATOM   2633 C  CB  . ILE A 1 378 ? 0.705   -13.985 -45.214 1.00 69.61  ? 641  ILE A CB  1 
ATOM   2634 C  CG1 . ILE A 1 378 ? 0.391   -12.487 -45.183 1.00 81.64  ? 641  ILE A CG1 1 
ATOM   2635 C  CG2 . ILE A 1 378 ? 0.349   -14.582 -46.571 1.00 65.53  ? 641  ILE A CG2 1 
ATOM   2636 C  CD1 . ILE A 1 378 ? -1.057  -12.141 -45.490 1.00 89.38  ? 641  ILE A CD1 1 
ATOM   2637 N  N   . ALA A 1 379 ? 1.396   -16.750 -43.668 1.00 52.41  ? 642  ALA A N   1 
ATOM   2638 C  CA  . ALA A 1 379 ? 1.794   -18.173 -43.785 1.00 56.59  ? 642  ALA A CA  1 
ATOM   2639 C  C   . ALA A 1 379 ? 0.846   -19.060 -42.948 1.00 54.31  ? 642  ALA A C   1 
ATOM   2640 O  O   . ALA A 1 379 ? 0.382   -20.083 -43.476 1.00 46.77  ? 642  ALA A O   1 
ATOM   2641 C  CB  . ALA A 1 379 ? 3.238   -18.338 -43.392 1.00 51.32  ? 642  ALA A CB  1 
ATOM   2642 N  N   . VAL A 1 380 ? 0.528   -18.637 -41.722 1.00 45.26  ? 643  VAL A N   1 
ATOM   2643 C  CA  . VAL A 1 380 ? -0.355  -19.364 -40.777 1.00 48.87  ? 643  VAL A CA  1 
ATOM   2644 C  C   . VAL A 1 380 ? -1.772  -19.407 -41.369 1.00 53.17  ? 643  VAL A C   1 
ATOM   2645 O  O   . VAL A 1 380 ? -2.373  -20.512 -41.418 1.00 44.28  ? 643  VAL A O   1 
ATOM   2646 C  CB  . VAL A 1 380 ? -0.305  -18.710 -39.385 1.00 47.64  ? 643  VAL A CB  1 
ATOM   2647 C  CG1 . VAL A 1 380 ? -1.457  -19.161 -38.496 1.00 46.58  ? 643  VAL A CG1 1 
ATOM   2648 C  CG2 . VAL A 1 380 ? 1.036   -18.983 -38.714 1.00 48.67  ? 643  VAL A CG2 1 
ATOM   2649 N  N   . LYS A 1 381 ? -2.262  -18.256 -41.841 1.00 53.45  ? 644  LYS A N   1 
ATOM   2650 C  CA  . LYS A 1 381 ? -3.612  -18.115 -42.432 1.00 49.70  ? 644  LYS A CA  1 
ATOM   2651 C  C   . LYS A 1 381 ? -3.695  -19.023 -43.656 1.00 48.63  ? 644  LYS A C   1 
ATOM   2652 O  O   . LYS A 1 381 ? -4.711  -19.758 -43.770 1.00 50.96  ? 644  LYS A O   1 
ATOM   2653 C  CB  . LYS A 1 381 ? -3.927  -16.652 -42.753 1.00 54.90  ? 644  LYS A CB  1 
ATOM   2654 C  CG  . LYS A 1 381 ? -4.158  -15.756 -41.544 1.00 61.55  ? 644  LYS A CG  1 
ATOM   2655 C  CD  . LYS A 1 381 ? -4.145  -14.259 -41.856 1.00 63.36  ? 644  LYS A CD  1 
ATOM   2656 C  CE  . LYS A 1 381 ? -4.770  -13.396 -40.776 1.00 62.06  ? 644  LYS A CE  1 
ATOM   2657 N  NZ  . LYS A 1 381 ? -3.748  -12.700 -39.961 1.00 69.13  ? 644  LYS A NZ  1 
ATOM   2658 N  N   . ASN A 1 382 ? -2.650  -19.040 -44.484 1.00 44.81  ? 645  ASN A N   1 
ATOM   2659 C  CA  . ASN A 1 382 ? -2.643  -19.803 -45.760 1.00 50.19  ? 645  ASN A CA  1 
ATOM   2660 C  C   . ASN A 1 382 ? -2.590  -21.301 -45.458 1.00 53.23  ? 645  ASN A C   1 
ATOM   2661 O  O   . ASN A 1 382 ? -3.202  -22.091 -46.206 1.00 42.89  ? 645  ASN A O   1 
ATOM   2662 C  CB  . ASN A 1 382 ? -1.462  -19.416 -46.660 1.00 58.97  ? 645  ASN A CB  1 
ATOM   2663 C  CG  . ASN A 1 382 ? -1.738  -18.203 -47.530 1.00 72.66  ? 645  ASN A CG  1 
ATOM   2664 O  OD1 . ASN A 1 382 ? -0.926  -17.279 -47.602 1.00 85.67  ? 645  ASN A OD1 1 
ATOM   2665 N  ND2 . ASN A 1 382 ? -2.883  -18.195 -48.196 1.00 74.21  ? 645  ASN A ND2 1 
ATOM   2666 N  N   . TRP A 1 383 ? -1.829  -21.679 -44.429 1.00 51.83  ? 646  TRP A N   1 
ATOM   2667 C  CA  . TRP A 1 383 ? -1.726  -23.091 -43.972 1.00 49.89  ? 646  TRP A CA  1 
ATOM   2668 C  C   . TRP A 1 383 ? -3.134  -23.595 -43.609 1.00 40.81  ? 646  TRP A C   1 
ATOM   2669 O  O   . TRP A 1 383 ? -3.616  -24.563 -44.210 1.00 37.11  ? 646  TRP A O   1 
ATOM   2670 C  CB  . TRP A 1 383 ? -0.738  -23.147 -42.811 1.00 46.28  ? 646  TRP A CB  1 
ATOM   2671 C  CG  . TRP A 1 383 ? -0.398  -24.514 -42.322 1.00 52.30  ? 646  TRP A CG  1 
ATOM   2672 C  CD1 . TRP A 1 383 ? 0.584   -25.355 -42.765 1.00 53.15  ? 646  TRP A CD1 1 
ATOM   2673 C  CD2 . TRP A 1 383 ? -1.019  -25.175 -41.214 1.00 52.40  ? 646  TRP A CD2 1 
ATOM   2674 N  NE1 . TRP A 1 383 ? 0.614   -26.495 -42.006 1.00 46.59  ? 646  TRP A NE1 1 
ATOM   2675 C  CE2 . TRP A 1 383 ? -0.351  -26.403 -41.039 1.00 52.21  ? 646  TRP A CE2 1 
ATOM   2676 C  CE3 . TRP A 1 383 ? -2.049  -24.829 -40.342 1.00 46.46  ? 646  TRP A CE3 1 
ATOM   2677 C  CZ2 . TRP A 1 383 ? -0.713  -27.297 -40.038 1.00 48.95  ? 646  TRP A CZ2 1 
ATOM   2678 C  CZ3 . TRP A 1 383 ? -2.395  -25.714 -39.350 1.00 46.90  ? 646  TRP A CZ3 1 
ATOM   2679 C  CH2 . TRP A 1 383 ? -1.720  -26.916 -39.187 1.00 45.69  ? 646  TRP A CH2 1 
ATOM   2680 N  N   . LEU A 1 384 ? -3.822  -22.860 -42.755 1.00 38.02  ? 647  LEU A N   1 
ATOM   2681 C  CA  . LEU A 1 384 ? -5.191  -23.202 -42.313 1.00 44.58  ? 647  LEU A CA  1 
ATOM   2682 C  C   . LEU A 1 384 ? -6.130  -23.399 -43.513 1.00 48.16  ? 647  LEU A C   1 
ATOM   2683 O  O   . LEU A 1 384 ? -6.906  -24.359 -43.522 1.00 46.31  ? 647  LEU A O   1 
ATOM   2684 C  CB  . LEU A 1 384 ? -5.674  -22.089 -41.382 1.00 41.71  ? 647  LEU A CB  1 
ATOM   2685 C  CG  . LEU A 1 384 ? -5.059  -22.115 -39.982 1.00 43.59  ? 647  LEU A CG  1 
ATOM   2686 C  CD1 . LEU A 1 384 ? -5.476  -20.894 -39.172 1.00 45.30  ? 647  LEU A CD1 1 
ATOM   2687 C  CD2 . LEU A 1 384 ? -5.430  -23.383 -39.227 1.00 45.14  ? 647  LEU A CD2 1 
ATOM   2688 N  N   . VAL A 1 385 ? -6.059  -22.489 -44.488 0.46 49.94  ? 648  VAL A N   1 
ATOM   2689 C  CA  . VAL A 1 385 ? -6.995  -22.429 -45.647 0.46 50.95  ? 648  VAL A CA  1 
ATOM   2690 C  C   . VAL A 1 385 ? -6.731  -23.633 -46.555 0.46 51.42  ? 648  VAL A C   1 
ATOM   2691 O  O   . VAL A 1 385 ? -7.705  -24.190 -47.098 0.46 54.66  ? 648  VAL A O   1 
ATOM   2692 C  CB  . VAL A 1 385 ? -6.852  -21.099 -46.412 0.46 53.36  ? 648  VAL A CB  1 
ATOM   2693 C  CG1 . VAL A 1 385 ? -7.545  -21.146 -47.765 0.46 52.78  ? 648  VAL A CG1 1 
ATOM   2694 C  CG2 . VAL A 1 385 ? -7.364  -19.924 -45.591 0.46 54.20  ? 648  VAL A CG2 1 
ATOM   2695 N  N   . ARG A 1 386 ? -5.466  -24.029 -46.700 0.50 51.58  ? 649  ARG A N   1 
ATOM   2696 C  CA  . ARG A 1 386 ? -5.052  -25.050 -47.698 0.50 55.08  ? 649  ARG A CA  1 
ATOM   2697 C  C   . ARG A 1 386 ? -4.980  -26.444 -47.050 0.50 53.47  ? 649  ARG A C   1 
ATOM   2698 O  O   . ARG A 1 386 ? -5.280  -27.424 -47.770 0.50 52.64  ? 649  ARG A O   1 
ATOM   2699 C  CB  . ARG A 1 386 ? -3.741  -24.636 -48.380 0.50 58.80  ? 649  ARG A CB  1 
ATOM   2700 C  CG  . ARG A 1 386 ? -2.475  -24.979 -47.607 0.50 64.18  ? 649  ARG A CG  1 
ATOM   2701 C  CD  . ARG A 1 386 ? -1.202  -24.868 -48.439 0.50 66.51  ? 649  ARG A CD  1 
ATOM   2702 N  NE  . ARG A 1 386 ? 0.005   -25.198 -47.684 0.50 66.24  ? 649  ARG A NE  1 
ATOM   2703 C  CZ  . ARG A 1 386 ? 0.708   -24.328 -46.965 0.50 65.20  ? 649  ARG A CZ  1 
ATOM   2704 N  NH1 . ARG A 1 386 ? 0.328   -23.063 -46.903 0.50 65.13  ? 649  ARG A NH1 1 
ATOM   2705 N  NH2 . ARG A 1 386 ? 1.784   -24.723 -46.310 0.50 66.17  ? 649  ARG A NH2 1 
ATOM   2706 N  N   . VAL A 1 387 ? -4.630  -26.558 -45.760 1.00 49.06  ? 650  VAL A N   1 
ATOM   2707 C  CA  . VAL A 1 387 ? -4.450  -27.912 -45.133 1.00 48.27  ? 650  VAL A CA  1 
ATOM   2708 C  C   . VAL A 1 387 ? -5.131  -28.079 -43.765 1.00 45.18  ? 650  VAL A C   1 
ATOM   2709 O  O   . VAL A 1 387 ? -5.035  -29.236 -43.230 1.00 41.83  ? 650  VAL A O   1 
ATOM   2710 C  CB  . VAL A 1 387 ? -2.956  -28.283 -45.010 1.00 40.44  ? 650  VAL A CB  1 
ATOM   2711 C  CG1 . VAL A 1 387 ? -2.278  -28.397 -46.352 1.00 39.97  ? 650  VAL A CG1 1 
ATOM   2712 C  CG2 . VAL A 1 387 ? -2.191  -27.350 -44.085 1.00 39.82  ? 650  VAL A CG2 1 
ATOM   2713 N  N   . GLY A 1 388 ? -5.746  -27.025 -43.213 1.00 41.58  ? 651  GLY A N   1 
ATOM   2714 C  CA  . GLY A 1 388 ? -6.369  -27.029 -41.868 1.00 38.07  ? 651  GLY A CA  1 
ATOM   2715 C  C   . GLY A 1 388 ? -7.288  -28.229 -41.680 1.00 38.23  ? 651  GLY A C   1 
ATOM   2716 O  O   . GLY A 1 388 ? -7.198  -28.912 -40.640 1.00 38.66  ? 651  GLY A O   1 
ATOM   2717 N  N   . ARG A 1 389 ? -8.086  -28.545 -42.689 1.00 36.08  ? 652  ARG A N   1 
ATOM   2718 C  CA  . ARG A 1 389 ? -9.120  -29.601 -42.582 1.00 39.29  ? 652  ARG A CA  1 
ATOM   2719 C  C   . ARG A 1 389 ? -8.402  -30.947 -42.534 1.00 37.47  ? 652  ARG A C   1 
ATOM   2720 O  O   . ARG A 1 389 ? -8.750  -31.795 -41.682 1.00 40.00  ? 652  ARG A O   1 
ATOM   2721 C  CB  . ARG A 1 389 ? -10.183 -29.476 -43.686 1.00 38.80  ? 652  ARG A CB  1 
ATOM   2722 C  CG  . ARG A 1 389 ? -11.132 -28.307 -43.451 1.00 42.97  ? 652  ARG A CG  1 
ATOM   2723 C  CD  . ARG A 1 389 ? -12.283 -28.197 -44.440 1.00 47.57  ? 652  ARG A CD  1 
ATOM   2724 N  NE  . ARG A 1 389 ? -13.158 -29.368 -44.418 1.00 54.09  ? 652  ARG A NE  1 
ATOM   2725 C  CZ  . ARG A 1 389 ? -14.225 -29.539 -43.624 1.00 53.86  ? 652  ARG A CZ  1 
ATOM   2726 N  NH1 . ARG A 1 389 ? -14.589 -28.621 -42.734 1.00 49.40  ? 652  ARG A NH1 1 
ATOM   2727 N  NH2 . ARG A 1 389 ? -14.914 -30.664 -43.719 1.00 54.08  ? 652  ARG A NH2 1 
ATOM   2728 N  N   . GLU A 1 390 ? -7.423  -31.153 -43.421 0.46 37.63  ? 653  GLU A N   1 
ATOM   2729 C  CA  . GLU A 1 390 ? -6.612  -32.401 -43.452 0.46 37.78  ? 653  GLU A CA  1 
ATOM   2730 C  C   . GLU A 1 390 ? -5.920  -32.584 -42.093 0.46 37.18  ? 653  GLU A C   1 
ATOM   2731 O  O   . GLU A 1 390 ? -5.969  -33.703 -41.554 0.46 37.27  ? 653  GLU A O   1 
ATOM   2732 C  CB  . GLU A 1 390 ? -5.592  -32.378 -44.590 0.46 36.16  ? 653  GLU A CB  1 
ATOM   2733 C  CG  . GLU A 1 390 ? -4.949  -33.729 -44.833 0.46 35.05  ? 653  GLU A CG  1 
ATOM   2734 C  CD  . GLU A 1 390 ? -3.878  -34.131 -43.830 0.46 35.01  ? 653  GLU A CD  1 
ATOM   2735 O  OE1 . GLU A 1 390 ? -3.499  -33.292 -42.986 0.46 34.52  ? 653  GLU A OE1 1 
ATOM   2736 O  OE2 . GLU A 1 390 ? -3.423  -35.288 -43.892 0.46 35.59  ? 653  GLU A OE2 1 
ATOM   2737 N  N   . ARG A 1 391 ? -5.335  -31.514 -41.550 1.00 36.27  ? 654  ARG A N   1 
ATOM   2738 C  CA  . ARG A 1 391 ? -4.616  -31.566 -40.265 1.00 39.25  ? 654  ARG A CA  1 
ATOM   2739 C  C   . ARG A 1 391 ? -5.598  -31.886 -39.127 1.00 35.78  ? 654  ARG A C   1 
ATOM   2740 O  O   . ARG A 1 391 ? -5.195  -32.614 -38.223 1.00 36.35  ? 654  ARG A O   1 
ATOM   2741 C  CB  . ARG A 1 391 ? -3.826  -30.265 -40.091 1.00 44.50  ? 654  ARG A CB  1 
ATOM   2742 C  CG  . ARG A 1 391 ? -2.804  -30.030 -41.200 1.00 43.52  ? 654  ARG A CG  1 
ATOM   2743 C  CD  . ARG A 1 391 ? -1.727  -31.091 -41.210 1.00 41.76  ? 654  ARG A CD  1 
ATOM   2744 N  NE  . ARG A 1 391 ? -0.618  -30.652 -42.034 1.00 48.22  ? 654  ARG A NE  1 
ATOM   2745 C  CZ  . ARG A 1 391 ? -0.507  -30.821 -43.354 1.00 49.90  ? 654  ARG A CZ  1 
ATOM   2746 N  NH1 . ARG A 1 391 ? -1.423  -31.455 -44.062 1.00 49.59  ? 654  ARG A NH1 1 
ATOM   2747 N  NH2 . ARG A 1 391 ? 0.557   -30.369 -43.975 1.00 55.03  ? 654  ARG A NH2 1 
ATOM   2748 N  N   . LEU A 1 392 ? -6.835  -31.393 -39.176 1.00 34.42  ? 655  LEU A N   1 
ATOM   2749 C  CA  . LEU A 1 392 ? -7.869  -31.696 -38.134 1.00 34.63  ? 655  LEU A CA  1 
ATOM   2750 C  C   . LEU A 1 392 ? -8.176  -33.191 -38.153 1.00 31.01  ? 655  LEU A C   1 
ATOM   2751 O  O   . LEU A 1 392 ? -8.338  -33.815 -37.079 1.00 29.46  ? 655  LEU A O   1 
ATOM   2752 C  CB  . LEU A 1 392 ? -9.149  -30.880 -38.347 1.00 34.42  ? 655  LEU A CB  1 
ATOM   2753 C  CG  . LEU A 1 392 ? -9.123  -29.420 -37.901 1.00 32.66  ? 655  LEU A CG  1 
ATOM   2754 C  CD1 . LEU A 1 392 ? -10.459 -28.769 -38.214 1.00 37.22  ? 655  LEU A CD1 1 
ATOM   2755 C  CD2 . LEU A 1 392 ? -8.818  -29.257 -36.436 1.00 31.90  ? 655  LEU A CD2 1 
ATOM   2756 N  N   . SER A 1 393 ? -8.243  -33.757 -39.357 0.46 31.01  ? 656  SER A N   1 
ATOM   2757 C  CA  . SER A 1 393 ? -8.614  -35.171 -39.612 0.46 31.54  ? 656  SER A CA  1 
ATOM   2758 C  C   . SER A 1 393 ? -7.573  -36.118 -39.009 0.46 31.92  ? 656  SER A C   1 
ATOM   2759 O  O   . SER A 1 393 ? -7.929  -37.280 -38.749 0.46 31.20  ? 656  SER A O   1 
ATOM   2760 C  CB  . SER A 1 393 ? -8.772  -35.406 -41.087 0.46 32.36  ? 656  SER A CB  1 
ATOM   2761 O  OG  . SER A 1 393 ? -7.614  -34.973 -41.783 0.46 32.24  ? 656  SER A OG  1 
ATOM   2762 N  N   . ARG A 1 394 ? -6.334  -35.646 -38.825 0.46 33.26  ? 657  ARG A N   1 
ATOM   2763 C  CA  . ARG A 1 394 ? -5.187  -36.451 -38.321 0.46 33.40  ? 657  ARG A CA  1 
ATOM   2764 C  C   . ARG A 1 394 ? -5.206  -36.512 -36.794 0.46 31.50  ? 657  ARG A C   1 
ATOM   2765 O  O   . ARG A 1 394 ? -4.135  -36.772 -36.200 0.46 29.67  ? 657  ARG A O   1 
ATOM   2766 C  CB  . ARG A 1 394 ? -3.848  -35.807 -38.683 0.46 35.42  ? 657  ARG A CB  1 
ATOM   2767 C  CG  . ARG A 1 394 ? -3.588  -35.675 -40.172 0.46 37.56  ? 657  ARG A CG  1 
ATOM   2768 C  CD  . ARG A 1 394 ? -2.264  -34.989 -40.428 0.46 38.15  ? 657  ARG A CD  1 
ATOM   2769 N  NE  . ARG A 1 394 ? -1.762  -35.437 -41.708 0.46 40.65  ? 657  ARG A NE  1 
ATOM   2770 C  CZ  . ARG A 1 394 ? -0.900  -36.427 -41.860 0.46 43.40  ? 657  ARG A CZ  1 
ATOM   2771 N  NH1 . ARG A 1 394 ? -0.425  -37.057 -40.799 0.46 43.76  ? 657  ARG A NH1 1 
ATOM   2772 N  NH2 . ARG A 1 394 ? -0.517  -36.783 -43.072 0.46 45.03  ? 657  ARG A NH2 1 
ATOM   2773 N  N   . MET A 1 395 ? -6.350  -36.233 -36.175 0.46 29.66  ? 658  MET A N   1 
ATOM   2774 C  CA  . MET A 1 395 ? -6.435  -36.140 -34.698 0.46 29.20  ? 658  MET A CA  1 
ATOM   2775 C  C   . MET A 1 395 ? -7.769  -36.708 -34.201 0.46 27.72  ? 658  MET A C   1 
ATOM   2776 O  O   . MET A 1 395 ? -8.756  -36.684 -34.956 0.46 25.92  ? 658  MET A O   1 
ATOM   2777 C  CB  . MET A 1 395 ? -6.267  -34.686 -34.246 0.46 30.27  ? 658  MET A CB  1 
ATOM   2778 C  CG  . MET A 1 395 ? -5.083  -33.985 -34.891 0.46 29.97  ? 658  MET A CG  1 
ATOM   2779 S  SD  . MET A 1 395 ? -4.518  -32.531 -33.958 0.46 30.87  ? 658  MET A SD  1 
ATOM   2780 C  CE  . MET A 1 395 ? -5.858  -31.379 -34.253 0.46 30.31  ? 658  MET A CE  1 
ATOM   2781 N  N   . ALA A 1 396 ? -7.756  -37.235 -32.976 1.00 26.74  ? 659  ALA A N   1 
ATOM   2782 C  CA  . ALA A 1 396 ? -8.942  -37.650 -32.235 1.00 28.16  ? 659  ALA A CA  1 
ATOM   2783 C  C   . ALA A 1 396 ? -8.883  -36.887 -30.891 1.00 28.81  ? 659  ALA A C   1 
ATOM   2784 O  O   . ALA A 1 396 ? -7.950  -37.149 -30.124 1.00 25.44  ? 659  ALA A O   1 
ATOM   2785 C  CB  . ALA A 1 396 ? -8.916  -39.142 -32.077 1.00 29.46  ? 659  ALA A CB  1 
ATOM   2786 N  N   . ILE A 1 397 ? -9.839  -35.981 -30.630 1.00 26.61  ? 660  ILE A N   1 
ATOM   2787 C  CA  . ILE A 1 397 ? -9.823  -35.076 -29.457 1.00 27.19  ? 660  ILE A CA  1 
ATOM   2788 C  C   . ILE A 1 397 ? -11.158 -35.167 -28.710 1.00 31.53  ? 660  ILE A C   1 
ATOM   2789 O  O   . ILE A 1 397 ? -12.246 -34.981 -29.314 1.00 27.27  ? 660  ILE A O   1 
ATOM   2790 C  CB  . ILE A 1 397 ? -9.498  -33.641 -29.873 1.00 27.90  ? 660  ILE A CB  1 
ATOM   2791 C  CG1 . ILE A 1 397 ? -8.228  -33.618 -30.731 1.00 31.42  ? 660  ILE A CG1 1 
ATOM   2792 C  CG2 . ILE A 1 397 ? -9.435  -32.766 -28.641 1.00 28.67  ? 660  ILE A CG2 1 
ATOM   2793 C  CD1 . ILE A 1 397 ? -7.384  -32.398 -30.680 1.00 30.48  ? 660  ILE A CD1 1 
ATOM   2794 N  N   . SER A 1 398 ? -11.044 -35.435 -27.413 1.00 29.24  ? 661  SER A N   1 
ATOM   2795 C  CA  . SER A 1 398 ? -12.171 -35.582 -26.491 1.00 31.39  ? 661  SER A CA  1 
ATOM   2796 C  C   . SER A 1 398 ? -11.859 -34.750 -25.265 1.00 31.77  ? 661  SER A C   1 
ATOM   2797 O  O   . SER A 1 398 ? -11.144 -35.271 -24.392 1.00 31.29  ? 661  SER A O   1 
ATOM   2798 C  CB  . SER A 1 398 ? -12.392 -37.014 -26.128 1.00 30.69  ? 661  SER A CB  1 
ATOM   2799 O  OG  . SER A 1 398 ? -13.696 -37.165 -25.600 1.00 29.50  ? 661  SER A OG  1 
ATOM   2800 N  N   . GLY A 1 399 ? -12.372 -33.525 -25.222 1.00 29.08  ? 662  GLY A N   1 
ATOM   2801 C  CA  . GLY A 1 399 ? -12.014 -32.589 -24.139 1.00 29.96  ? 662  GLY A CA  1 
ATOM   2802 C  C   . GLY A 1 399 ? -10.495 -32.463 -24.036 1.00 31.76  ? 662  GLY A C   1 
ATOM   2803 O  O   . GLY A 1 399 ? -9.838  -32.186 -25.080 1.00 28.60  ? 662  GLY A O   1 
ATOM   2804 N  N   . ASP A 1 400 ? -9.925  -32.716 -22.848 1.00 32.02  ? 663  ASP A N   1 
ATOM   2805 C  CA  . ASP A 1 400 ? -8.481  -32.492 -22.609 1.00 32.87  ? 663  ASP A CA  1 
ATOM   2806 C  C   . ASP A 1 400 ? -7.671  -33.645 -23.185 1.00 32.37  ? 663  ASP A C   1 
ATOM   2807 O  O   . ASP A 1 400 ? -6.445  -33.569 -23.127 1.00 30.09  ? 663  ASP A O   1 
ATOM   2808 C  CB  . ASP A 1 400 ? -8.183  -32.276 -21.132 1.00 39.06  ? 663  ASP A CB  1 
ATOM   2809 C  CG  . ASP A 1 400 ? -8.482  -33.460 -20.253 1.00 42.35  ? 663  ASP A CG  1 
ATOM   2810 O  OD1 . ASP A 1 400 ? -9.087  -34.425 -20.736 1.00 43.20  ? 663  ASP A OD1 1 
ATOM   2811 O  OD2 . ASP A 1 400 ? -8.106  -33.388 -19.088 1.00 50.04  ? 663  ASP A OD2 1 
ATOM   2812 N  N   . ASP A 1 401 ? -8.324  -34.635 -23.783 1.00 31.21  ? 664  ASP A N   1 
ATOM   2813 C  CA  . ASP A 1 401 ? -7.645  -35.861 -24.256 1.00 30.78  ? 664  ASP A CA  1 
ATOM   2814 C  C   . ASP A 1 401 ? -7.439  -35.786 -25.758 1.00 31.82  ? 664  ASP A C   1 
ATOM   2815 O  O   . ASP A 1 401 ? -8.403  -35.424 -26.455 1.00 33.70  ? 664  ASP A O   1 
ATOM   2816 C  CB  . ASP A 1 401 ? -8.421  -37.130 -23.917 1.00 32.99  ? 664  ASP A CB  1 
ATOM   2817 C  CG  . ASP A 1 401 ? -7.473  -38.273 -23.645 1.00 33.13  ? 664  ASP A CG  1 
ATOM   2818 O  OD1 . ASP A 1 401 ? -6.322  -37.970 -23.395 1.00 35.21  ? 664  ASP A OD1 1 
ATOM   2819 O  OD2 . ASP A 1 401 ? -7.870  -39.414 -23.727 1.00 32.61  ? 664  ASP A OD2 1 
ATOM   2820 N  N   . CYS A 1 402 ? -6.235  -36.137 -26.226 1.00 30.15  ? 665  CYS A N   1 
ATOM   2821 C  CA  . CYS A 1 402 ? -5.915  -36.164 -27.669 1.00 30.29  ? 665  CYS A CA  1 
ATOM   2822 C  C   . CYS A 1 402 ? -4.962  -37.300 -28.040 1.00 30.38  ? 665  CYS A C   1 
ATOM   2823 O  O   . CYS A 1 402 ? -4.148  -37.748 -27.200 1.00 29.02  ? 665  CYS A O   1 
ATOM   2824 C  CB  . CYS A 1 402 ? -5.308  -34.848 -28.130 1.00 33.69  ? 665  CYS A CB  1 
ATOM   2825 S  SG  . CYS A 1 402 ? -3.650  -34.566 -27.454 1.00 34.61  ? 665  CYS A SG  1 
ATOM   2826 N  N   . VAL A 1 403 ? -5.121  -37.720 -29.291 1.00 31.39  ? 666  VAL A N   1 
ATOM   2827 C  CA  . VAL A 1 403 ? -4.180  -38.516 -30.123 1.00 31.46  ? 666  VAL A CA  1 
ATOM   2828 C  C   . VAL A 1 403 ? -3.940  -37.694 -31.406 1.00 32.08  ? 666  VAL A C   1 
ATOM   2829 O  O   . VAL A 1 403 ? -4.930  -37.247 -32.009 1.00 32.43  ? 666  VAL A O   1 
ATOM   2830 C  CB  . VAL A 1 403 ? -4.791  -39.902 -30.389 1.00 28.81  ? 666  VAL A CB  1 
ATOM   2831 C  CG1 . VAL A 1 403 ? -3.951  -40.760 -31.328 1.00 28.87  ? 666  VAL A CG1 1 
ATOM   2832 C  CG2 . VAL A 1 403 ? -5.058  -40.622 -29.062 1.00 28.18  ? 666  VAL A CG2 1 
ATOM   2833 N  N   . VAL A 1 404 ? -2.682  -37.428 -31.766 1.00 33.07  ? 667  VAL A N   1 
ATOM   2834 C  CA  . VAL A 1 404 ? -2.285  -36.695 -33.016 1.00 30.76  ? 667  VAL A CA  1 
ATOM   2835 C  C   . VAL A 1 404 ? -1.343  -37.584 -33.814 1.00 30.48  ? 667  VAL A C   1 
ATOM   2836 O  O   . VAL A 1 404 ? -0.341  -38.062 -33.218 1.00 29.03  ? 667  VAL A O   1 
ATOM   2837 C  CB  . VAL A 1 404 ? -1.587  -35.357 -32.725 1.00 32.65  ? 667  VAL A CB  1 
ATOM   2838 C  CG1 . VAL A 1 404 ? -1.340  -34.569 -34.008 1.00 33.91  ? 667  VAL A CG1 1 
ATOM   2839 C  CG2 . VAL A 1 404 ? -2.338  -34.507 -31.715 1.00 33.65  ? 667  VAL A CG2 1 
ATOM   2840 N  N   . LYS A 1 405 ? -1.645  -37.793 -35.090 1.00 28.49  ? 668  LYS A N   1 
ATOM   2841 C  CA  . LYS A 1 405 ? -0.695  -38.371 -36.065 1.00 30.74  ? 668  LYS A CA  1 
ATOM   2842 C  C   . LYS A 1 405 ? -0.223  -37.245 -36.982 1.00 35.35  ? 668  LYS A C   1 
ATOM   2843 O  O   . LYS A 1 405 ? -0.807  -36.979 -38.040 1.00 30.80  ? 668  LYS A O   1 
ATOM   2844 C  CB  . LYS A 1 405 ? -1.267  -39.492 -36.929 1.00 34.32  ? 668  LYS A CB  1 
ATOM   2845 C  CG  . LYS A 1 405 ? -0.177  -40.123 -37.783 1.00 37.75  ? 668  LYS A CG  1 
ATOM   2846 C  CD  . LYS A 1 405 ? -0.523  -41.402 -38.486 1.00 39.31  ? 668  LYS A CD  1 
ATOM   2847 C  CE  . LYS A 1 405 ? 0.733   -42.067 -39.004 1.00 41.05  ? 668  LYS A CE  1 
ATOM   2848 N  NZ  . LYS A 1 405 ? 0.414   -43.238 -39.846 1.00 45.77  ? 668  LYS A NZ  1 
ATOM   2849 N  N   . PRO A 1 406 ? 0.887   -36.577 -36.614 1.00 35.13  ? 669  PRO A N   1 
ATOM   2850 C  CA  . PRO A 1 406 ? 1.417   -35.478 -37.414 1.00 34.94  ? 669  PRO A CA  1 
ATOM   2851 C  C   . PRO A 1 406 ? 2.074   -35.955 -38.712 1.00 33.55  ? 669  PRO A C   1 
ATOM   2852 O  O   . PRO A 1 406 ? 2.321   -37.140 -38.891 1.00 36.07  ? 669  PRO A O   1 
ATOM   2853 C  CB  . PRO A 1 406 ? 2.418   -34.846 -36.457 1.00 32.95  ? 669  PRO A CB  1 
ATOM   2854 C  CG  . PRO A 1 406 ? 2.937   -36.035 -35.713 1.00 34.33  ? 669  PRO A CG  1 
ATOM   2855 C  CD  . PRO A 1 406 ? 1.693   -36.839 -35.420 1.00 34.24  ? 669  PRO A CD  1 
ATOM   2856 N  N   . LEU A 1 407 ? 2.306   -34.997 -39.607 1.00 36.82  ? 670  LEU A N   1 
ATOM   2857 C  CA  . LEU A 1 407 ? 2.950   -35.204 -40.931 1.00 38.08  ? 670  LEU A CA  1 
ATOM   2858 C  C   . LEU A 1 407 ? 4.273   -35.968 -40.753 1.00 36.14  ? 670  LEU A C   1 
ATOM   2859 O  O   . LEU A 1 407 ? 4.561   -36.844 -41.607 1.00 36.62  ? 670  LEU A O   1 
ATOM   2860 C  CB  . LEU A 1 407 ? 3.158   -33.831 -41.572 1.00 40.21  ? 670  LEU A CB  1 
ATOM   2861 C  CG  . LEU A 1 407 ? 3.043   -33.820 -43.085 1.00 47.32  ? 670  LEU A CG  1 
ATOM   2862 C  CD1 . LEU A 1 407 ? 1.609   -34.048 -43.502 1.00 48.56  ? 670  LEU A CD1 1 
ATOM   2863 C  CD2 . LEU A 1 407 ? 3.561   -32.504 -43.647 1.00 58.30  ? 670  LEU A CD2 1 
ATOM   2864 N  N   . ASP A 1 408 ? 5.025   -35.711 -39.669 1.00 34.26  ? 671  ASP A N   1 
ATOM   2865 C  CA  . ASP A 1 408 ? 6.319   -36.420 -39.404 1.00 37.91  ? 671  ASP A CA  1 
ATOM   2866 C  C   . ASP A 1 408 ? 6.696   -36.294 -37.925 1.00 34.70  ? 671  ASP A C   1 
ATOM   2867 O  O   . ASP A 1 408 ? 5.859   -35.821 -37.153 1.00 33.94  ? 671  ASP A O   1 
ATOM   2868 C  CB  . ASP A 1 408 ? 7.408   -35.898 -40.350 1.00 37.74  ? 671  ASP A CB  1 
ATOM   2869 C  CG  . ASP A 1 408 ? 7.449   -34.398 -40.322 1.00 36.05  ? 671  ASP A CG  1 
ATOM   2870 O  OD1 . ASP A 1 408 ? 7.786   -33.857 -39.227 1.00 40.87  ? 671  ASP A OD1 1 
ATOM   2871 O  OD2 . ASP A 1 408 ? 7.103   -33.784 -41.364 1.00 38.39  ? 671  ASP A OD2 1 
ATOM   2872 N  N   . ASP A 1 409 ? 7.913   -36.671 -37.535 1.00 36.09  ? 672  ASP A N   1 
ATOM   2873 C  CA  . ASP A 1 409 ? 8.261   -36.774 -36.089 1.00 34.69  ? 672  ASP A CA  1 
ATOM   2874 C  C   . ASP A 1 409 ? 8.905   -35.483 -35.559 1.00 33.93  ? 672  ASP A C   1 
ATOM   2875 O  O   . ASP A 1 409 ? 9.180   -35.431 -34.335 1.00 35.78  ? 672  ASP A O   1 
ATOM   2876 C  CB  . ASP A 1 409 ? 9.000   -38.080 -35.814 1.00 35.68  ? 672  ASP A CB  1 
ATOM   2877 C  CG  . ASP A 1 409 ? 8.053   -39.263 -35.868 1.00 39.38  ? 672  ASP A CG  1 
ATOM   2878 O  OD1 . ASP A 1 409 ? 6.952   -39.164 -35.279 1.00 39.34  ? 672  ASP A OD1 1 
ATOM   2879 O  OD2 . ASP A 1 409 ? 8.379   -40.234 -36.556 1.00 43.43  ? 672  ASP A OD2 1 
ATOM   2880 N  N   . ARG A 1 410 ? 8.958   -34.410 -36.354 1.00 34.34  ? 673  ARG A N   1 
ATOM   2881 C  CA  . ARG A 1 410 ? 9.412   -33.084 -35.853 1.00 32.64  ? 673  ARG A CA  1 
ATOM   2882 C  C   . ARG A 1 410 ? 8.469   -32.581 -34.755 1.00 34.70  ? 673  ARG A C   1 
ATOM   2883 O  O   . ARG A 1 410 ? 8.911   -31.797 -33.895 1.00 37.86  ? 673  ARG A O   1 
ATOM   2884 C  CB  . ARG A 1 410 ? 9.397   -32.055 -36.985 1.00 37.54  ? 673  ARG A CB  1 
ATOM   2885 C  CG  . ARG A 1 410 ? 10.500  -32.219 -38.016 1.00 39.85  ? 673  ARG A CG  1 
ATOM   2886 C  CD  . ARG A 1 410 ? 10.361  -31.138 -39.067 1.00 37.78  ? 673  ARG A CD  1 
ATOM   2887 N  NE  . ARG A 1 410 ? 9.294   -31.504 -39.989 1.00 40.61  ? 673  ARG A NE  1 
ATOM   2888 C  CZ  . ARG A 1 410 ? 8.759   -30.710 -40.909 1.00 44.65  ? 673  ARG A CZ  1 
ATOM   2889 N  NH1 . ARG A 1 410 ? 9.198   -29.468 -41.045 1.00 40.10  ? 673  ARG A NH1 1 
ATOM   2890 N  NH2 . ARG A 1 410 ? 7.776   -31.163 -41.687 1.00 47.61  ? 673  ARG A NH2 1 
ATOM   2891 N  N   . PHE A 1 411 ? 7.176   -32.929 -34.852 1.00 34.11  ? 674  PHE A N   1 
ATOM   2892 C  CA  . PHE A 1 411 ? 6.129   -32.653 -33.834 1.00 32.49  ? 674  PHE A CA  1 
ATOM   2893 C  C   . PHE A 1 411 ? 6.631   -33.007 -32.419 1.00 31.70  ? 674  PHE A C   1 
ATOM   2894 O  O   . PHE A 1 411 ? 6.324   -32.252 -31.481 1.00 34.49  ? 674  PHE A O   1 
ATOM   2895 C  CB  . PHE A 1 411 ? 4.876   -33.463 -34.201 1.00 37.13  ? 674  PHE A CB  1 
ATOM   2896 C  CG  . PHE A 1 411 ? 3.677   -33.281 -33.311 1.00 35.07  ? 674  PHE A CG  1 
ATOM   2897 C  CD1 . PHE A 1 411 ? 3.538   -34.022 -32.153 1.00 34.62  ? 674  PHE A CD1 1 
ATOM   2898 C  CD2 . PHE A 1 411 ? 2.669   -32.392 -33.656 1.00 35.28  ? 674  PHE A CD2 1 
ATOM   2899 C  CE1 . PHE A 1 411 ? 2.416   -33.861 -31.348 1.00 34.79  ? 674  PHE A CE1 1 
ATOM   2900 C  CE2 . PHE A 1 411 ? 1.550   -32.233 -32.851 1.00 33.98  ? 674  PHE A CE2 1 
ATOM   2901 C  CZ  . PHE A 1 411 ? 1.422   -32.978 -31.696 1.00 32.12  ? 674  PHE A CZ  1 
ATOM   2902 N  N   . ALA A 1 412 ? 7.373   -34.107 -32.256 1.00 31.08  ? 675  ALA A N   1 
ATOM   2903 C  CA  . ALA A 1 412 ? 7.834   -34.617 -30.942 1.00 32.18  ? 675  ALA A CA  1 
ATOM   2904 C  C   . ALA A 1 412 ? 8.602   -33.548 -30.159 1.00 33.64  ? 675  ALA A C   1 
ATOM   2905 O  O   . ALA A 1 412 ? 8.404   -33.455 -28.942 1.00 30.81  ? 675  ALA A O   1 
ATOM   2906 C  CB  . ALA A 1 412 ? 8.662   -35.856 -31.131 1.00 33.55  ? 675  ALA A CB  1 
ATOM   2907 N  N   . SER A 1 413 ? 9.410   -32.727 -30.837 1.00 35.85  ? 676  SER A N   1 
ATOM   2908 C  CA  . SER A 1 413 ? 10.280  -31.710 -30.179 1.00 37.78  ? 676  SER A CA  1 
ATOM   2909 C  C   . SER A 1 413 ? 9.753   -30.304 -30.435 1.00 36.87  ? 676  SER A C   1 
ATOM   2910 O  O   . SER A 1 413 ? 10.475  -29.366 -30.117 1.00 41.56  ? 676  SER A O   1 
ATOM   2911 C  CB  . SER A 1 413 ? 11.726  -31.845 -30.600 1.00 36.48  ? 676  SER A CB  1 
ATOM   2912 O  OG  . SER A 1 413 ? 11.801  -32.280 -31.949 1.00 42.28  ? 676  SER A OG  1 
ATOM   2913 N  N   . ALA A 1 414 ? 8.527   -30.159 -30.946 1.00 39.29  ? 677  ALA A N   1 
ATOM   2914 C  CA  . ALA A 1 414 ? 7.893   -28.839 -31.180 1.00 37.77  ? 677  ALA A CA  1 
ATOM   2915 C  C   . ALA A 1 414 ? 7.144   -28.450 -29.906 1.00 38.63  ? 677  ALA A C   1 
ATOM   2916 O  O   . ALA A 1 414 ? 5.964   -28.778 -29.813 1.00 42.71  ? 677  ALA A O   1 
ATOM   2917 C  CB  . ALA A 1 414 ? 6.999   -28.891 -32.391 1.00 35.70  ? 677  ALA A CB  1 
ATOM   2918 N  N   . LEU A 1 415 ? 7.802   -27.797 -28.957 1.00 34.58  ? 678  LEU A N   1 
ATOM   2919 C  CA  . LEU A 1 415 ? 7.283   -27.682 -27.578 1.00 38.89  ? 678  LEU A CA  1 
ATOM   2920 C  C   . LEU A 1 415 ? 7.096   -26.227 -27.166 1.00 39.09  ? 678  LEU A C   1 
ATOM   2921 O  O   . LEU A 1 415 ? 6.565   -26.037 -26.041 1.00 40.06  ? 678  LEU A O   1 
ATOM   2922 C  CB  . LEU A 1 415 ? 8.212   -28.400 -26.592 1.00 38.67  ? 678  LEU A CB  1 
ATOM   2923 C  CG  . LEU A 1 415 ? 8.333   -29.915 -26.780 1.00 43.07  ? 678  LEU A CG  1 
ATOM   2924 C  CD1 . LEU A 1 415 ? 9.456   -30.500 -25.925 1.00 42.21  ? 678  LEU A CD1 1 
ATOM   2925 C  CD2 . LEU A 1 415 ? 7.019   -30.617 -26.472 1.00 43.67  ? 678  LEU A CD2 1 
ATOM   2926 N  N   . THR A 1 416 ? 7.469   -25.242 -27.986 1.00 37.37  ? 679  THR A N   1 
ATOM   2927 C  CA  . THR A 1 416 ? 7.593   -23.855 -27.462 1.00 40.60  ? 679  THR A CA  1 
ATOM   2928 C  C   . THR A 1 416 ? 6.192   -23.258 -27.314 1.00 37.75  ? 679  THR A C   1 
ATOM   2929 O  O   . THR A 1 416 ? 5.880   -22.698 -26.225 1.00 40.88  ? 679  THR A O   1 
ATOM   2930 C  CB  . THR A 1 416 ? 8.528   -22.980 -28.300 1.00 44.00  ? 679  THR A CB  1 
ATOM   2931 O  OG1 . THR A 1 416 ? 7.956   -22.832 -29.594 1.00 54.68  ? 679  THR A OG1 1 
ATOM   2932 C  CG2 . THR A 1 416 ? 9.910   -23.567 -28.445 1.00 47.17  ? 679  THR A CG2 1 
ATOM   2933 N  N   . ALA A 1 417 ? 5.369   -23.355 -28.354 1.00 37.85  ? 680  ALA A N   1 
ATOM   2934 C  CA  . ALA A 1 417 ? 3.986   -22.815 -28.321 1.00 39.09  ? 680  ALA A CA  1 
ATOM   2935 C  C   . ALA A 1 417 ? 3.178   -23.573 -27.261 1.00 39.89  ? 680  ALA A C   1 
ATOM   2936 O  O   . ALA A 1 417 ? 2.484   -22.902 -26.457 1.00 42.28  ? 680  ALA A O   1 
ATOM   2937 C  CB  . ALA A 1 417 ? 3.346   -22.868 -29.686 1.00 40.92  ? 680  ALA A CB  1 
ATOM   2938 N  N   . LEU A 1 418 ? 3.301   -24.906 -27.223 1.00 38.45  ? 681  LEU A N   1 
ATOM   2939 C  CA  . LEU A 1 418 ? 2.533   -25.770 -26.285 1.00 37.23  ? 681  LEU A CA  1 
ATOM   2940 C  C   . LEU A 1 418 ? 2.832   -25.352 -24.853 1.00 38.57  ? 681  LEU A C   1 
ATOM   2941 O  O   . LEU A 1 418 ? 1.870   -25.215 -24.054 1.00 38.29  ? 681  LEU A O   1 
ATOM   2942 C  CB  . LEU A 1 418 ? 2.915   -27.236 -26.503 1.00 39.40  ? 681  LEU A CB  1 
ATOM   2943 C  CG  . LEU A 1 418 ? 2.062   -28.267 -25.767 1.00 38.10  ? 681  LEU A CG  1 
ATOM   2944 C  CD1 . LEU A 1 418 ? 0.661   -28.294 -26.341 1.00 34.99  ? 681  LEU A CD1 1 
ATOM   2945 C  CD2 . LEU A 1 418 ? 2.695   -29.658 -25.829 1.00 37.90  ? 681  LEU A CD2 1 
ATOM   2946 N  N   . ASN A 1 419 ? 4.122   -25.192 -24.543 1.00 38.87  ? 682  ASN A N   1 
ATOM   2947 C  CA  . ASN A 1 419 ? 4.587   -24.814 -23.187 1.00 42.91  ? 682  ASN A CA  1 
ATOM   2948 C  C   . ASN A 1 419 ? 4.129   -23.377 -22.886 1.00 40.06  ? 682  ASN A C   1 
ATOM   2949 O  O   . ASN A 1 419 ? 3.619   -23.146 -21.782 1.00 43.77  ? 682  ASN A O   1 
ATOM   2950 C  CB  . ASN A 1 419 ? 6.096   -25.030 -23.065 1.00 45.71  ? 682  ASN A CB  1 
ATOM   2951 C  CG  . ASN A 1 419 ? 6.467   -26.458 -22.712 1.00 43.76  ? 682  ASN A CG  1 
ATOM   2952 O  OD1 . ASN A 1 419 ? 5.697   -27.168 -22.063 1.00 45.99  ? 682  ASN A OD1 1 
ATOM   2953 N  ND2 . ASN A 1 419 ? 7.636   -26.892 -23.143 1.00 38.99  ? 682  ASN A ND2 1 
ATOM   2954 N  N   . ASP A 1 420 ? 4.258   -22.462 -23.848 1.00 41.44  ? 683  ASP A N   1 
ATOM   2955 C  CA  . ASP A 1 420 ? 3.885   -21.024 -23.689 1.00 45.61  ? 683  ASP A CA  1 
ATOM   2956 C  C   . ASP A 1 420 ? 2.354   -20.840 -23.564 1.00 45.07  ? 683  ASP A C   1 
ATOM   2957 O  O   . ASP A 1 420 ? 1.933   -19.943 -22.819 1.00 42.07  ? 683  ASP A O   1 
ATOM   2958 C  CB  . ASP A 1 420 ? 4.449   -20.155 -24.821 1.00 43.09  ? 683  ASP A CB  1 
ATOM   2959 C  CG  . ASP A 1 420 ? 4.336   -18.670 -24.501 1.00 45.96  ? 683  ASP A CG  1 
ATOM   2960 O  OD1 . ASP A 1 420 ? 4.725   -18.300 -23.373 1.00 44.82  ? 683  ASP A OD1 1 
ATOM   2961 O  OD2 . ASP A 1 420 ? 3.787   -17.893 -25.347 1.00 45.93  ? 683  ASP A OD2 1 
ATOM   2962 N  N   . MET A 1 421 ? 1.528   -21.673 -24.205 1.00 43.97  ? 684  MET A N   1 
ATOM   2963 C  CA  . MET A 1 421 ? 0.051   -21.620 -24.004 1.00 41.55  ? 684  MET A CA  1 
ATOM   2964 C  C   . MET A 1 421 ? -0.295  -22.087 -22.583 1.00 39.49  ? 684  MET A C   1 
ATOM   2965 O  O   . MET A 1 421 ? -1.458  -21.950 -22.198 1.00 40.08  ? 684  MET A O   1 
ATOM   2966 C  CB  . MET A 1 421 ? -0.684  -22.475 -25.043 1.00 42.12  ? 684  MET A CB  1 
ATOM   2967 C  CG  . MET A 1 421 ? -0.540  -21.927 -26.447 1.00 40.95  ? 684  MET A CG  1 
ATOM   2968 S  SD  . MET A 1 421 ? -1.426  -22.864 -27.715 1.00 47.89  ? 684  MET A SD  1 
ATOM   2969 C  CE  . MET A 1 421 ? -0.232  -24.109 -28.193 1.00 53.51  ? 684  MET A CE  1 
ATOM   2970 N  N   . GLY A 1 422 ? 0.660   -22.646 -21.839 1.00 37.98  ? 685  GLY A N   1 
ATOM   2971 C  CA  . GLY A 1 422 ? 0.415   -23.241 -20.507 1.00 34.41  ? 685  GLY A CA  1 
ATOM   2972 C  C   . GLY A 1 422 ? -0.032  -24.700 -20.547 1.00 36.29  ? 685  GLY A C   1 
ATOM   2973 O  O   . GLY A 1 422 ? -0.327  -25.219 -19.460 1.00 33.40  ? 685  GLY A O   1 
ATOM   2974 N  N   . LYS A 1 423 ? -0.049  -25.363 -21.719 1.00 36.82  ? 686  LYS A N   1 
ATOM   2975 C  CA  . LYS A 1 423 ? -0.515  -26.780 -21.880 1.00 40.33  ? 686  LYS A CA  1 
ATOM   2976 C  C   . LYS A 1 423 ? 0.672   -27.747 -21.702 1.00 41.81  ? 686  LYS A C   1 
ATOM   2977 O  O   . LYS A 1 423 ? 1.008   -28.563 -22.613 1.00 40.84  ? 686  LYS A O   1 
ATOM   2978 C  CB  . LYS A 1 423 ? -1.268  -26.925 -23.203 1.00 36.51  ? 686  LYS A CB  1 
ATOM   2979 C  CG  . LYS A 1 423 ? -2.415  -25.937 -23.357 1.00 36.27  ? 686  LYS A CG  1 
ATOM   2980 C  CD  . LYS A 1 423 ? -3.311  -25.876 -22.114 1.00 42.83  ? 686  LYS A CD  1 
ATOM   2981 C  CE  . LYS A 1 423 ? -4.524  -24.975 -22.231 1.00 40.90  ? 686  LYS A CE  1 
ATOM   2982 N  NZ  . LYS A 1 423 ? -4.137  -23.596 -22.609 1.00 43.83  ? 686  LYS A NZ  1 
ATOM   2983 N  N   . VAL A 1 424 ? 1.207   -27.705 -20.495 1.00 41.80  ? 687  VAL A N   1 
ATOM   2984 C  CA  . VAL A 1 424 ? 2.464   -28.373 -20.063 1.00 45.42  ? 687  VAL A CA  1 
ATOM   2985 C  C   . VAL A 1 424 ? 2.164   -29.860 -19.921 1.00 38.23  ? 687  VAL A C   1 
ATOM   2986 O  O   . VAL A 1 424 ? 1.149   -30.207 -19.248 1.00 39.27  ? 687  VAL A O   1 
ATOM   2987 C  CB  . VAL A 1 424 ? 2.978   -27.723 -18.760 1.00 50.22  ? 687  VAL A CB  1 
ATOM   2988 C  CG1 . VAL A 1 424 ? 3.787   -28.655 -17.880 1.00 53.61  ? 687  VAL A CG1 1 
ATOM   2989 C  CG2 . VAL A 1 424 ? 3.769   -26.468 -19.073 1.00 50.49  ? 687  VAL A CG2 1 
ATOM   2990 N  N   . ARG A 1 425 ? 2.992   -30.696 -20.549 1.00 34.73  ? 688  ARG A N   1 
ATOM   2991 C  CA  . ARG A 1 425 ? 2.736   -32.150 -20.620 1.00 36.17  ? 688  ARG A CA  1 
ATOM   2992 C  C   . ARG A 1 425 ? 2.953   -32.735 -19.217 1.00 38.02  ? 688  ARG A C   1 
ATOM   2993 O  O   . ARG A 1 425 ? 3.780   -32.182 -18.473 1.00 41.32  ? 688  ARG A O   1 
ATOM   2994 C  CB  . ARG A 1 425 ? 3.627   -32.796 -21.678 1.00 34.33  ? 688  ARG A CB  1 
ATOM   2995 C  CG  . ARG A 1 425 ? 3.389   -32.295 -23.089 1.00 36.56  ? 688  ARG A CG  1 
ATOM   2996 C  CD  . ARG A 1 425 ? 4.525   -32.698 -24.015 1.00 40.72  ? 688  ARG A CD  1 
ATOM   2997 N  NE  . ARG A 1 425 ? 5.801   -32.119 -23.591 1.00 40.30  ? 688  ARG A NE  1 
ATOM   2998 C  CZ  . ARG A 1 425 ? 7.018   -32.617 -23.824 1.00 39.23  ? 688  ARG A CZ  1 
ATOM   2999 N  NH1 . ARG A 1 425 ? 7.207   -33.716 -24.546 1.00 39.38  ? 688  ARG A NH1 1 
ATOM   3000 N  NH2 . ARG A 1 425 ? 8.060   -31.965 -23.345 1.00 39.99  ? 688  ARG A NH2 1 
ATOM   3001 N  N   . LYS A 1 426 ? 2.189   -33.766 -18.862 1.00 37.98  ? 689  LYS A N   1 
ATOM   3002 C  CA  . LYS A 1 426 ? 2.308   -34.549 -17.598 1.00 45.32  ? 689  LYS A CA  1 
ATOM   3003 C  C   . LYS A 1 426 ? 3.457   -35.589 -17.697 1.00 48.75  ? 689  LYS A C   1 
ATOM   3004 O  O   . LYS A 1 426 ? 3.680   -36.161 -18.792 1.00 47.16  ? 689  LYS A O   1 
ATOM   3005 C  CB  . LYS A 1 426 ? 0.971   -35.263 -17.367 1.00 48.44  ? 689  LYS A CB  1 
ATOM   3006 C  CG  . LYS A 1 426 ? 0.610   -35.579 -15.921 1.00 57.12  ? 689  LYS A CG  1 
ATOM   3007 C  CD  . LYS A 1 426 ? -0.585  -36.496 -15.768 1.00 57.69  ? 689  LYS A CD  1 
ATOM   3008 C  CE  . LYS A 1 426 ? -0.619  -37.578 -16.826 1.00 71.86  ? 689  LYS A CE  1 
ATOM   3009 N  NZ  . LYS A 1 426 ? -1.786  -38.478 -16.660 1.00 81.10  ? 689  LYS A NZ  1 
ATOM   3010 N  N   . ASP A 1 427 ? 4.171   -35.831 -16.593 0.26 47.79  ? 690  ASP A N   1 
ATOM   3011 C  CA  . ASP A 1 427 ? 5.130   -36.962 -16.426 0.26 48.68  ? 690  ASP A CA  1 
ATOM   3012 C  C   . ASP A 1 427 ? 6.250   -36.930 -17.478 0.26 49.42  ? 690  ASP A C   1 
ATOM   3013 O  O   . ASP A 1 427 ? 6.584   -38.017 -18.000 0.26 50.51  ? 690  ASP A O   1 
ATOM   3014 C  CB  . ASP A 1 427 ? 4.425   -38.316 -16.549 0.26 48.19  ? 690  ASP A CB  1 
ATOM   3015 C  CG  . ASP A 1 427 ? 3.245   -38.501 -15.618 0.26 46.94  ? 690  ASP A CG  1 
ATOM   3016 O  OD1 . ASP A 1 427 ? 3.164   -37.755 -14.621 0.26 47.87  ? 690  ASP A OD1 1 
ATOM   3017 O  OD2 . ASP A 1 427 ? 2.420   -39.393 -15.902 0.26 43.94  ? 690  ASP A OD2 1 
ATOM   3018 N  N   . ILE A 1 428 ? 6.820   -35.759 -17.778 1.00 49.99  ? 691  ILE A N   1 
ATOM   3019 C  CA  . ILE A 1 428 ? 7.943   -35.644 -18.751 1.00 48.10  ? 691  ILE A CA  1 
ATOM   3020 C  C   . ILE A 1 428 ? 8.558   -34.267 -18.520 1.00 49.59  ? 691  ILE A C   1 
ATOM   3021 O  O   . ILE A 1 428 ? 7.790   -33.357 -18.229 1.00 54.75  ? 691  ILE A O   1 
ATOM   3022 C  CB  . ILE A 1 428 ? 7.499   -35.877 -20.209 1.00 47.41  ? 691  ILE A CB  1 
ATOM   3023 C  CG1 . ILE A 1 428 ? 8.724   -36.015 -21.117 1.00 47.51  ? 691  ILE A CG1 1 
ATOM   3024 C  CG2 . ILE A 1 428 ? 6.551   -34.790 -20.710 1.00 48.15  ? 691  ILE A CG2 1 
ATOM   3025 C  CD1 . ILE A 1 428 ? 8.420   -36.591 -22.483 1.00 45.34  ? 691  ILE A CD1 1 
ATOM   3026 N  N   . GLN A 1 429 ? 9.884   -34.130 -18.570 1.00 53.76  ? 692  GLN A N   1 
ATOM   3027 C  CA  . GLN A 1 429 ? 10.547  -32.810 -18.389 1.00 55.77  ? 692  GLN A CA  1 
ATOM   3028 C  C   . GLN A 1 429 ? 10.064  -31.867 -19.494 1.00 52.51  ? 692  GLN A C   1 
ATOM   3029 O  O   . GLN A 1 429 ? 9.934   -32.297 -20.672 1.00 46.17  ? 692  GLN A O   1 
ATOM   3030 C  CB  . GLN A 1 429 ? 12.072  -32.919 -18.348 1.00 69.16  ? 692  GLN A CB  1 
ATOM   3031 C  CG  . GLN A 1 429 ? 12.651  -32.759 -16.943 1.00 79.79  ? 692  GLN A CG  1 
ATOM   3032 C  CD  . GLN A 1 429 ? 13.928  -33.534 -16.717 1.00 85.37  ? 692  GLN A CD  1 
ATOM   3033 O  OE1 . GLN A 1 429 ? 14.396  -34.274 -17.583 1.00 95.88  ? 692  GLN A OE1 1 
ATOM   3034 N  NE2 . GLN A 1 429 ? 14.499  -33.383 -15.532 1.00 89.68  ? 692  GLN A NE2 1 
ATOM   3035 N  N   . GLN A 1 430 ? 9.835   -30.604 -19.116 0.26 51.71  ? 693  GLN A N   1 
ATOM   3036 C  CA  . GLN A 1 430 ? 9.194   -29.542 -19.937 0.26 51.94  ? 693  GLN A CA  1 
ATOM   3037 C  C   . GLN A 1 430 ? 9.790   -29.518 -21.350 0.26 50.18  ? 693  GLN A C   1 
ATOM   3038 O  O   . GLN A 1 430 ? 9.011   -29.318 -22.300 0.26 49.68  ? 693  GLN A O   1 
ATOM   3039 C  CB  . GLN A 1 430 ? 9.369   -28.181 -19.261 0.26 53.23  ? 693  GLN A CB  1 
ATOM   3040 C  CG  . GLN A 1 430 ? 8.153   -27.276 -19.399 0.26 54.61  ? 693  GLN A CG  1 
ATOM   3041 C  CD  . GLN A 1 430 ? 8.472   -25.832 -19.096 0.26 55.55  ? 693  GLN A CD  1 
ATOM   3042 O  OE1 . GLN A 1 430 ? 9.625   -25.408 -19.143 0.26 55.99  ? 693  GLN A OE1 1 
ATOM   3043 N  NE2 . GLN A 1 430 ? 7.442   -25.059 -18.791 0.26 55.33  ? 693  GLN A NE2 1 
ATOM   3044 N  N   . TRP A 1 431 ? 11.108  -29.714 -21.479 1.00 48.72  ? 694  TRP A N   1 
ATOM   3045 C  CA  . TRP A 1 431 ? 11.828  -29.572 -22.783 1.00 47.99  ? 694  TRP A CA  1 
ATOM   3046 C  C   . TRP A 1 431 ? 12.262  -30.911 -23.404 1.00 42.47  ? 694  TRP A C   1 
ATOM   3047 O  O   . TRP A 1 431 ? 12.835  -30.861 -24.492 1.00 42.95  ? 694  TRP A O   1 
ATOM   3048 C  CB  . TRP A 1 431 ? 12.982  -28.567 -22.626 1.00 54.32  ? 694  TRP A CB  1 
ATOM   3049 C  CG  . TRP A 1 431 ? 12.473  -27.201 -22.264 1.00 53.61  ? 694  TRP A CG  1 
ATOM   3050 C  CD1 . TRP A 1 431 ? 12.635  -26.546 -21.082 1.00 53.11  ? 694  TRP A CD1 1 
ATOM   3051 C  CD2 . TRP A 1 431 ? 11.609  -26.368 -23.067 1.00 54.07  ? 694  TRP A CD2 1 
ATOM   3052 N  NE1 . TRP A 1 431 ? 11.969  -25.348 -21.110 1.00 58.78  ? 694  TRP A NE1 1 
ATOM   3053 C  CE2 . TRP A 1 431 ? 11.324  -25.216 -22.310 1.00 56.79  ? 694  TRP A CE2 1 
ATOM   3054 C  CE3 . TRP A 1 431 ? 11.063  -26.481 -24.351 1.00 52.36  ? 694  TRP A CE3 1 
ATOM   3055 C  CZ2 . TRP A 1 431 ? 10.497  -24.200 -22.788 1.00 58.63  ? 694  TRP A CZ2 1 
ATOM   3056 C  CZ3 . TRP A 1 431 ? 10.278  -25.460 -24.841 1.00 55.87  ? 694  TRP A CZ3 1 
ATOM   3057 C  CH2 . TRP A 1 431 ? 9.992   -24.340 -24.063 1.00 58.91  ? 694  TRP A CH2 1 
ATOM   3058 N  N   . GLU A 1 432 ? 11.853  -32.043 -22.825 1.00 41.23  ? 695  GLU A N   1 
ATOM   3059 C  CA  . GLU A 1 432 ? 12.138  -33.423 -23.307 1.00 45.52  ? 695  GLU A CA  1 
ATOM   3060 C  C   . GLU A 1 432 ? 11.154  -33.789 -24.427 1.00 44.75  ? 695  GLU A C   1 
ATOM   3061 O  O   . GLU A 1 432 ? 9.938   -33.658 -24.283 1.00 39.33  ? 695  GLU A O   1 
ATOM   3062 C  CB  . GLU A 1 432 ? 12.087  -34.348 -22.076 1.00 50.31  ? 695  GLU A CB  1 
ATOM   3063 C  CG  . GLU A 1 432 ? 12.706  -35.717 -22.261 1.00 55.98  ? 695  GLU A CG  1 
ATOM   3064 C  CD  . GLU A 1 432 ? 14.164  -35.711 -22.717 1.00 67.37  ? 695  GLU A CD  1 
ATOM   3065 O  OE1 . GLU A 1 432 ? 14.505  -36.579 -23.574 1.00 69.64  ? 695  GLU A OE1 1 
ATOM   3066 O  OE2 . GLU A 1 432 ? 14.965  -34.832 -22.235 1.00 63.65  ? 695  GLU A OE2 1 
ATOM   3067 N  N   . PRO A 1 433 ? 11.632  -34.254 -25.601 1.00 41.29  ? 696  PRO A N   1 
ATOM   3068 C  CA  . PRO A 1 433 ? 10.741  -34.613 -26.706 1.00 37.45  ? 696  PRO A CA  1 
ATOM   3069 C  C   . PRO A 1 433 ? 9.732   -35.711 -26.367 1.00 38.45  ? 696  PRO A C   1 
ATOM   3070 O  O   . PRO A 1 433 ? 10.034  -36.560 -25.597 1.00 37.30  ? 696  PRO A O   1 
ATOM   3071 C  CB  . PRO A 1 433 ? 11.658  -35.112 -27.822 1.00 42.41  ? 696  PRO A CB  1 
ATOM   3072 C  CG  . PRO A 1 433 ? 13.042  -34.529 -27.445 1.00 44.81  ? 696  PRO A CG  1 
ATOM   3073 C  CD  . PRO A 1 433 ? 13.049  -34.438 -25.936 1.00 43.67  ? 696  PRO A CD  1 
ATOM   3074 N  N   . SER A 1 434 ? 8.539   -35.624 -26.946 1.00 36.26  ? 697  SER A N   1 
ATOM   3075 C  CA  . SER A 1 434 ? 7.426   -36.566 -26.726 1.00 37.10  ? 697  SER A CA  1 
ATOM   3076 C  C   . SER A 1 434 ? 7.835   -37.952 -27.240 1.00 35.20  ? 697  SER A C   1 
ATOM   3077 O  O   . SER A 1 434 ? 8.490   -38.034 -28.258 1.00 38.48  ? 697  SER A O   1 
ATOM   3078 C  CB  . SER A 1 434 ? 6.172   -36.061 -27.419 1.00 35.59  ? 697  SER A CB  1 
ATOM   3079 O  OG  . SER A 1 434 ? 5.707   -34.884 -26.804 1.00 35.07  ? 697  SER A OG  1 
ATOM   3080 N  N   . ARG A 1 435 ? 7.422   -39.000 -26.549 1.00 40.26  ? 698  ARG A N   1 
ATOM   3081 C  CA  . ARG A 1 435 ? 7.625   -40.403 -26.959 1.00 46.38  ? 698  ARG A CA  1 
ATOM   3082 C  C   . ARG A 1 435 ? 6.354   -40.802 -27.700 1.00 44.78  ? 698  ARG A C   1 
ATOM   3083 O  O   . ARG A 1 435 ? 5.290   -40.804 -27.071 1.00 49.09  ? 698  ARG A O   1 
ATOM   3084 C  CB  . ARG A 1 435 ? 7.938   -41.261 -25.725 1.00 52.66  ? 698  ARG A CB  1 
ATOM   3085 C  CG  . ARG A 1 435 ? 9.339   -41.035 -25.167 1.00 65.42  ? 698  ARG A CG  1 
ATOM   3086 C  CD  . ARG A 1 435 ? 9.631   -41.752 -23.852 1.00 78.65  ? 698  ARG A CD  1 
ATOM   3087 N  NE  . ARG A 1 435 ? 9.282   -41.000 -22.638 1.00 94.41  ? 698  ARG A NE  1 
ATOM   3088 C  CZ  . ARG A 1 435 ? 9.998   -40.003 -22.095 1.00 94.84  ? 698  ARG A CZ  1 
ATOM   3089 N  NH1 . ARG A 1 435 ? 11.119  -39.585 -22.663 1.00 94.17  ? 698  ARG A NH1 1 
ATOM   3090 N  NH2 . ARG A 1 435 ? 9.578   -39.416 -20.984 1.00 88.12  ? 698  ARG A NH2 1 
ATOM   3091 N  N   . GLY A 1 436 ? 6.464   -41.077 -28.990 1.00 42.19  ? 699  GLY A N   1 
ATOM   3092 C  CA  . GLY A 1 436 ? 5.328   -41.452 -29.850 1.00 42.66  ? 699  GLY A CA  1 
ATOM   3093 C  C   . GLY A 1 436 ? 5.056   -42.941 -29.783 1.00 40.65  ? 699  GLY A C   1 
ATOM   3094 O  O   . GLY A 1 436 ? 5.859   -43.665 -29.222 1.00 40.77  ? 699  GLY A O   1 
ATOM   3095 N  N   . TRP A 1 437 ? 3.914   -43.366 -30.297 1.00 37.86  ? 700  TRP A N   1 
ATOM   3096 C  CA  . TRP A 1 437 ? 3.510   -44.780 -30.363 1.00 34.16  ? 700  TRP A CA  1 
ATOM   3097 C  C   . TRP A 1 437 ? 3.620   -45.216 -31.817 1.00 32.58  ? 700  TRP A C   1 
ATOM   3098 O  O   . TRP A 1 437 ? 3.172   -44.460 -32.685 1.00 33.64  ? 700  TRP A O   1 
ATOM   3099 C  CB  . TRP A 1 437 ? 2.089   -44.946 -29.847 1.00 32.65  ? 700  TRP A CB  1 
ATOM   3100 C  CG  . TRP A 1 437 ? 1.901   -44.537 -28.430 1.00 28.02  ? 700  TRP A CG  1 
ATOM   3101 C  CD1 . TRP A 1 437 ? 1.604   -43.296 -27.953 1.00 29.88  ? 700  TRP A CD1 1 
ATOM   3102 C  CD2 . TRP A 1 437 ? 2.043   -45.385 -27.282 1.00 26.10  ? 700  TRP A CD2 1 
ATOM   3103 N  NE1 . TRP A 1 437 ? 1.540   -43.318 -26.580 1.00 27.86  ? 700  TRP A NE1 1 
ATOM   3104 C  CE2 . TRP A 1 437 ? 1.789   -44.589 -26.142 1.00 26.11  ? 700  TRP A CE2 1 
ATOM   3105 C  CE3 . TRP A 1 437 ? 2.366   -46.720 -27.120 1.00 25.70  ? 700  TRP A CE3 1 
ATOM   3106 C  CZ2 . TRP A 1 437 ? 1.811   -45.096 -24.853 1.00 26.11  ? 700  TRP A CZ2 1 
ATOM   3107 C  CZ3 . TRP A 1 437 ? 2.401   -47.220 -25.845 1.00 30.72  ? 700  TRP A CZ3 1 
ATOM   3108 C  CH2 . TRP A 1 437 ? 2.152   -46.415 -24.729 1.00 28.87  ? 700  TRP A CH2 1 
ATOM   3109 N  N   . ASN A 1 438 ? 4.163   -46.392 -32.058 1.00 30.24  ? 701  ASN A N   1 
ATOM   3110 C  CA  . ASN A 1 438 ? 4.344   -46.924 -33.422 1.00 37.63  ? 701  ASN A CA  1 
ATOM   3111 C  C   . ASN A 1 438 ? 3.150   -47.772 -33.816 1.00 38.90  ? 701  ASN A C   1 
ATOM   3112 O  O   . ASN A 1 438 ? 3.038   -48.018 -35.030 1.00 40.97  ? 701  ASN A O   1 
ATOM   3113 C  CB  . ASN A 1 438 ? 5.629   -47.742 -33.526 1.00 42.37  ? 701  ASN A CB  1 
ATOM   3114 C  CG  . ASN A 1 438 ? 6.852   -46.864 -33.347 1.00 49.94  ? 701  ASN A CG  1 
ATOM   3115 O  OD1 . ASN A 1 438 ? 7.709   -47.145 -32.501 1.00 61.27  ? 701  ASN A OD1 1 
ATOM   3116 N  ND2 . ASN A 1 438 ? 6.910   -45.776 -34.109 1.00 46.44  ? 701  ASN A ND2 1 
ATOM   3117 N  N   . ASP A 1 439 ? 2.350   -48.232 -32.846 1.00 37.88  ? 702  ASP A N   1 
ATOM   3118 C  CA  . ASP A 1 439 ? 1.229   -49.183 -33.106 1.00 44.96  ? 702  ASP A CA  1 
ATOM   3119 C  C   . ASP A 1 439 ? -0.075  -48.594 -32.539 1.00 37.25  ? 702  ASP A C   1 
ATOM   3120 O  O   . ASP A 1 439 ? -0.142  -48.355 -31.334 1.00 34.40  ? 702  ASP A O   1 
ATOM   3121 C  CB  . ASP A 1 439 ? 1.653   -50.566 -32.593 1.00 47.89  ? 702  ASP A CB  1 
ATOM   3122 C  CG  . ASP A 1 439 ? 0.589   -51.653 -32.543 1.00 54.23  ? 702  ASP A CG  1 
ATOM   3123 O  OD1 . ASP A 1 439 ? -0.483  -51.480 -33.190 1.00 51.78  ? 702  ASP A OD1 1 
ATOM   3124 O  OD2 . ASP A 1 439 ? 0.864   -52.684 -31.865 1.00 48.92  ? 702  ASP A OD2 1 
ATOM   3125 N  N   . TRP A 1 440 ? -1.083  -48.373 -33.385 1.00 36.65  ? 703  TRP A N   1 
ATOM   3126 C  CA  . TRP A 1 440 ? -2.376  -47.757 -32.981 1.00 33.99  ? 703  TRP A CA  1 
ATOM   3127 C  C   . TRP A 1 440 ? -3.050  -48.585 -31.878 1.00 31.76  ? 703  TRP A C   1 
ATOM   3128 O  O   . TRP A 1 440 ? -3.771  -47.997 -31.075 1.00 35.29  ? 703  TRP A O   1 
ATOM   3129 C  CB  . TRP A 1 440 ? -3.294  -47.529 -34.176 1.00 32.59  ? 703  TRP A CB  1 
ATOM   3130 C  CG  . TRP A 1 440 ? -3.835  -48.776 -34.823 1.00 39.09  ? 703  TRP A CG  1 
ATOM   3131 C  CD1 . TRP A 1 440 ? -3.318  -49.436 -35.908 1.00 35.71  ? 703  TRP A CD1 1 
ATOM   3132 C  CD2 . TRP A 1 440 ? -5.041  -49.486 -34.476 1.00 36.45  ? 703  TRP A CD2 1 
ATOM   3133 N  NE1 . TRP A 1 440 ? -4.129  -50.485 -36.265 1.00 34.06  ? 703  TRP A NE1 1 
ATOM   3134 C  CE2 . TRP A 1 440 ? -5.169  -50.567 -35.383 1.00 36.47  ? 703  TRP A CE2 1 
ATOM   3135 C  CE3 . TRP A 1 440 ? -6.018  -49.320 -33.497 1.00 34.51  ? 703  TRP A CE3 1 
ATOM   3136 C  CZ2 . TRP A 1 440 ? -6.216  -51.485 -35.315 1.00 37.43  ? 703  TRP A CZ2 1 
ATOM   3137 C  CZ3 . TRP A 1 440 ? -7.060  -50.220 -33.440 1.00 34.74  ? 703  TRP A CZ3 1 
ATOM   3138 C  CH2 . TRP A 1 440 ? -7.158  -51.284 -34.335 1.00 37.27  ? 703  TRP A CH2 1 
ATOM   3139 N  N   . THR A 1 441 ? -2.763  -49.876 -31.763 1.00 30.96  ? 704  THR A N   1 
ATOM   3140 C  CA  . THR A 1 441 ? -3.392  -50.767 -30.747 1.00 30.52  ? 704  THR A CA  1 
ATOM   3141 C  C   . THR A 1 441 ? -2.756  -50.615 -29.361 1.00 29.50  ? 704  THR A C   1 
ATOM   3142 O  O   . THR A 1 441 ? -3.191  -51.294 -28.431 1.00 29.22  ? 704  THR A O   1 
ATOM   3143 C  CB  . THR A 1 441 ? -3.376  -52.221 -31.215 1.00 29.82  ? 704  THR A CB  1 
ATOM   3144 O  OG1 . THR A 1 441 ? -2.023  -52.677 -31.276 1.00 27.49  ? 704  THR A OG1 1 
ATOM   3145 C  CG2 . THR A 1 441 ? -4.038  -52.395 -32.571 1.00 32.31  ? 704  THR A CG2 1 
ATOM   3146 N  N   . GLN A 1 442 ? -1.768  -49.733 -29.224 0.50 29.89  ? 705  GLN A N   1 
ATOM   3147 C  CA  . GLN A 1 442 ? -1.072  -49.457 -27.940 0.50 30.55  ? 705  GLN A CA  1 
ATOM   3148 C  C   . GLN A 1 442 ? -1.344  -48.027 -27.459 0.50 28.84  ? 705  GLN A C   1 
ATOM   3149 O  O   . GLN A 1 442 ? -0.995  -47.723 -26.302 0.50 26.90  ? 705  GLN A O   1 
ATOM   3150 C  CB  . GLN A 1 442 ? 0.422   -49.668 -28.157 0.50 34.00  ? 705  GLN A CB  1 
ATOM   3151 C  CG  . GLN A 1 442 ? 0.767   -51.098 -28.518 0.50 35.24  ? 705  GLN A CG  1 
ATOM   3152 C  CD  . GLN A 1 442 ? 1.637   -51.703 -27.449 0.50 37.21  ? 705  GLN A CD  1 
ATOM   3153 O  OE1 . GLN A 1 442 ? 2.708   -51.189 -27.134 0.50 37.35  ? 705  GLN A OE1 1 
ATOM   3154 N  NE2 . GLN A 1 442 ? 1.174   -52.804 -26.883 0.50 41.44  ? 705  GLN A NE2 1 
ATOM   3155 N  N   . VAL A 1 443 ? -1.888  -47.174 -28.328 1.00 27.92  ? 706  VAL A N   1 
ATOM   3156 C  CA  . VAL A 1 443 ? -2.230  -45.770 -27.993 1.00 31.00  ? 706  VAL A CA  1 
ATOM   3157 C  C   . VAL A 1 443 ? -3.313  -45.745 -26.926 1.00 27.82  ? 706  VAL A C   1 
ATOM   3158 O  O   . VAL A 1 443 ? -4.355  -46.364 -27.104 1.00 29.79  ? 706  VAL A O   1 
ATOM   3159 C  CB  . VAL A 1 443 ? -2.718  -45.016 -29.240 1.00 31.12  ? 706  VAL A CB  1 
ATOM   3160 C  CG1 . VAL A 1 443 ? -3.226  -43.630 -28.895 1.00 35.81  ? 706  VAL A CG1 1 
ATOM   3161 C  CG2 . VAL A 1 443 ? -1.639  -44.945 -30.288 1.00 34.54  ? 706  VAL A CG2 1 
ATOM   3162 N  N   . PRO A 1 444 ? -3.094  -45.008 -25.819 1.00 26.65  ? 707  PRO A N   1 
ATOM   3163 C  CA  . PRO A 1 444 ? -4.156  -44.718 -24.860 1.00 27.85  ? 707  PRO A CA  1 
ATOM   3164 C  C   . PRO A 1 444 ? -5.049  -43.577 -25.344 1.00 27.04  ? 707  PRO A C   1 
ATOM   3165 O  O   . PRO A 1 444 ? -4.538  -42.591 -25.824 1.00 31.34  ? 707  PRO A O   1 
ATOM   3166 C  CB  . PRO A 1 444 ? -3.405  -44.281 -23.603 1.00 28.45  ? 707  PRO A CB  1 
ATOM   3167 C  CG  . PRO A 1 444 ? -2.116  -43.645 -24.153 1.00 29.47  ? 707  PRO A CG  1 
ATOM   3168 C  CD  . PRO A 1 444 ? -1.824  -44.362 -25.463 1.00 28.31  ? 707  PRO A CD  1 
ATOM   3169 N  N   . PHE A 1 445 ? -6.363  -43.736 -25.188 1.00 28.20  ? 708  PHE A N   1 
ATOM   3170 C  CA  . PHE A 1 445 ? -7.392  -42.718 -25.509 1.00 27.58  ? 708  PHE A CA  1 
ATOM   3171 C  C   . PHE A 1 445 ? -8.627  -42.981 -24.672 1.00 26.94  ? 708  PHE A C   1 
ATOM   3172 O  O   . PHE A 1 445 ? -9.098  -44.122 -24.730 1.00 26.03  ? 708  PHE A O   1 
ATOM   3173 C  CB  . PHE A 1 445 ? -7.794  -42.783 -26.987 1.00 29.31  ? 708  PHE A CB  1 
ATOM   3174 C  CG  . PHE A 1 445 ? -8.619  -41.612 -27.479 1.00 31.14  ? 708  PHE A CG  1 
ATOM   3175 C  CD1 . PHE A 1 445 ? -8.328  -40.311 -27.082 1.00 30.01  ? 708  PHE A CD1 1 
ATOM   3176 C  CD2 . PHE A 1 445 ? -9.626  -41.800 -28.419 1.00 33.37  ? 708  PHE A CD2 1 
ATOM   3177 C  CE1 . PHE A 1 445 ? -9.043  -39.232 -27.581 1.00 32.03  ? 708  PHE A CE1 1 
ATOM   3178 C  CE2 . PHE A 1 445 ? -10.352 -40.723 -28.919 1.00 34.30  ? 708  PHE A CE2 1 
ATOM   3179 C  CZ  . PHE A 1 445 ? -10.065 -39.442 -28.484 1.00 35.70  ? 708  PHE A CZ  1 
ATOM   3180 N  N   . CYS A 1 446 ? -9.128  -41.963 -23.974 1.00 27.07  ? 709  CYS A N   1 
ATOM   3181 C  CA  . CYS A 1 446 ? -10.378 -41.999 -23.159 1.00 28.29  ? 709  CYS A CA  1 
ATOM   3182 C  C   . CYS A 1 446 ? -10.359 -43.184 -22.186 1.00 28.92  ? 709  CYS A C   1 
ATOM   3183 O  O   . CYS A 1 446 ? -11.388 -43.893 -22.092 1.00 28.68  ? 709  CYS A O   1 
ATOM   3184 C  CB  . CYS A 1 446 ? -11.616 -42.042 -24.036 1.00 27.59  ? 709  CYS A CB  1 
ATOM   3185 S  SG  . CYS A 1 446 ? -11.796 -40.585 -25.105 1.00 34.50  ? 709  CYS A SG  1 
ATOM   3186 N  N   . SER A 1 447 ? -9.203  -43.422 -21.553 1.00 28.77  ? 710  SER A N   1 
ATOM   3187 C  CA  . SER A 1 447 ? -8.983  -44.440 -20.498 1.00 29.36  ? 710  SER A CA  1 
ATOM   3188 C  C   . SER A 1 447 ? -8.964  -45.857 -21.106 1.00 30.74  ? 710  SER A C   1 
ATOM   3189 O  O   . SER A 1 447 ? -9.001  -46.842 -20.322 1.00 30.51  ? 710  SER A O   1 
ATOM   3190 C  CB  . SER A 1 447 ? -10.041 -44.287 -19.410 1.00 34.56  ? 710  SER A CB  1 
ATOM   3191 O  OG  . SER A 1 447 ? -9.820  -43.103 -18.652 1.00 36.60  ? 710  SER A OG  1 
ATOM   3192 N  N   . HIS A 1 448 ? -8.874  -45.989 -22.434 1.00 26.53  ? 711  HIS A N   1 
ATOM   3193 C  CA  . HIS A 1 448 ? -8.863  -47.304 -23.127 1.00 27.43  ? 711  HIS A CA  1 
ATOM   3194 C  C   . HIS A 1 448 ? -7.646  -47.515 -24.047 1.00 26.46  ? 711  HIS A C   1 
ATOM   3195 O  O   . HIS A 1 448 ? -6.928  -46.551 -24.370 1.00 27.15  ? 711  HIS A O   1 
ATOM   3196 C  CB  . HIS A 1 448 ? -10.160 -47.460 -23.922 1.00 27.10  ? 711  HIS A CB  1 
ATOM   3197 C  CG  . HIS A 1 448 ? -11.336 -47.676 -23.046 1.00 28.21  ? 711  HIS A CG  1 
ATOM   3198 N  ND1 . HIS A 1 448 ? -11.873 -46.661 -22.269 1.00 33.04  ? 711  HIS A ND1 1 
ATOM   3199 C  CD2 . HIS A 1 448 ? -12.059 -48.789 -22.796 1.00 31.30  ? 711  HIS A CD2 1 
ATOM   3200 C  CE1 . HIS A 1 448 ? -12.884 -47.157 -21.577 1.00 33.51  ? 711  HIS A CE1 1 
ATOM   3201 N  NE2 . HIS A 1 448 ? -13.032 -48.469 -21.887 1.00 29.63  ? 711  HIS A NE2 1 
ATOM   3202 N  N   . HIS A 1 449 ? -7.466  -48.760 -24.479 1.00 25.96  ? 712  HIS A N   1 
ATOM   3203 C  CA  . HIS A 1 449 ? -6.687  -49.171 -25.677 1.00 26.11  ? 712  HIS A CA  1 
ATOM   3204 C  C   . HIS A 1 449 ? -7.632  -50.044 -26.487 1.00 25.60  ? 712  HIS A C   1 
ATOM   3205 O  O   . HIS A 1 449 ? -8.686  -50.401 -26.007 1.00 24.66  ? 712  HIS A O   1 
ATOM   3206 C  CB  . HIS A 1 449 ? -5.366  -49.861 -25.334 1.00 23.94  ? 712  HIS A CB  1 
ATOM   3207 C  CG  . HIS A 1 449 ? -5.537  -51.101 -24.520 1.00 23.68  ? 712  HIS A CG  1 
ATOM   3208 N  ND1 . HIS A 1 449 ? -5.703  -51.067 -23.149 1.00 24.95  ? 712  HIS A ND1 1 
ATOM   3209 C  CD2 . HIS A 1 449 ? -5.600  -52.395 -24.873 1.00 23.24  ? 712  HIS A CD2 1 
ATOM   3210 C  CE1 . HIS A 1 449 ? -5.837  -52.295 -22.679 1.00 25.16  ? 712  HIS A CE1 1 
ATOM   3211 N  NE2 . HIS A 1 449 ? -5.789  -53.132 -23.726 1.00 27.41  ? 712  HIS A NE2 1 
ATOM   3212 N  N   . PHE A 1 450 ? -7.245  -50.361 -27.720 0.50 26.46  ? 713  PHE A N   1 
ATOM   3213 C  CA  . PHE A 1 450 ? -8.142  -50.986 -28.724 0.50 27.28  ? 713  PHE A CA  1 
ATOM   3214 C  C   . PHE A 1 450 ? -7.440  -52.176 -29.373 0.50 27.23  ? 713  PHE A C   1 
ATOM   3215 O  O   . PHE A 1 450 ? -6.305  -52.028 -29.835 0.50 28.10  ? 713  PHE A O   1 
ATOM   3216 C  CB  . PHE A 1 450 ? -8.622  -49.918 -29.708 0.50 26.90  ? 713  PHE A CB  1 
ATOM   3217 C  CG  . PHE A 1 450 ? -9.397  -48.830 -29.011 0.50 27.00  ? 713  PHE A CG  1 
ATOM   3218 C  CD1 . PHE A 1 450 ? -8.738  -47.797 -28.366 0.50 27.34  ? 713  PHE A CD1 1 
ATOM   3219 C  CD2 . PHE A 1 450 ? -10.778 -48.879 -28.934 0.50 27.48  ? 713  PHE A CD2 1 
ATOM   3220 C  CE1 . PHE A 1 450 ? -9.447  -46.815 -27.693 0.50 27.46  ? 713  PHE A CE1 1 
ATOM   3221 C  CE2 . PHE A 1 450 ? -11.484 -47.900 -28.252 0.50 27.60  ? 713  PHE A CE2 1 
ATOM   3222 C  CZ  . PHE A 1 450 ? -10.817 -46.875 -27.626 0.50 26.93  ? 713  PHE A CZ  1 
ATOM   3223 N  N   . HIS A 1 451 ? -8.110  -53.331 -29.367 1.00 28.20  ? 714  HIS A N   1 
ATOM   3224 C  CA  . HIS A 1 451 ? -7.613  -54.566 -30.004 1.00 30.21  ? 714  HIS A CA  1 
ATOM   3225 C  C   . HIS A 1 451 ? -8.296  -54.692 -31.353 1.00 31.12  ? 714  HIS A C   1 
ATOM   3226 O  O   . HIS A 1 451 ? -9.477  -54.297 -31.455 1.00 31.91  ? 714  HIS A O   1 
ATOM   3227 C  CB  . HIS A 1 451 ? -7.847  -55.757 -29.079 1.00 29.53  ? 714  HIS A CB  1 
ATOM   3228 C  CG  . HIS A 1 451 ? -7.112  -55.735 -27.777 1.00 28.05  ? 714  HIS A CG  1 
ATOM   3229 N  ND1 . HIS A 1 451 ? -6.062  -56.565 -27.516 1.00 29.45  ? 714  HIS A ND1 1 
ATOM   3230 C  CD2 . HIS A 1 451 ? -7.344  -55.071 -26.624 1.00 28.79  ? 714  HIS A CD2 1 
ATOM   3231 C  CE1 . HIS A 1 451 ? -5.685  -56.416 -26.260 1.00 28.55  ? 714  HIS A CE1 1 
ATOM   3232 N  NE2 . HIS A 1 451 ? -6.445  -55.494 -25.698 1.00 23.25  ? 714  HIS A NE2 1 
ATOM   3233 N  N   . GLU A 1 452 ? -7.573  -55.238 -32.324 1.00 36.78  ? 715  GLU A N   1 
ATOM   3234 C  CA  . GLU A 1 452 ? -8.116  -55.727 -33.618 1.00 37.31  ? 715  GLU A CA  1 
ATOM   3235 C  C   . GLU A 1 452 ? -8.426  -57.218 -33.456 1.00 38.25  ? 715  GLU A C   1 
ATOM   3236 O  O   . GLU A 1 452 ? -7.594  -57.947 -32.929 1.00 41.36  ? 715  GLU A O   1 
ATOM   3237 C  CB  . GLU A 1 452 ? -7.137  -55.460 -34.751 1.00 40.55  ? 715  GLU A CB  1 
ATOM   3238 C  CG  . GLU A 1 452 ? -7.839  -55.277 -36.077 1.00 47.99  ? 715  GLU A CG  1 
ATOM   3239 C  CD  . GLU A 1 452 ? -6.931  -54.900 -37.240 1.00 52.97  ? 715  GLU A CD  1 
ATOM   3240 O  OE1 . GLU A 1 452 ? -7.291  -53.964 -38.036 1.00 49.31  ? 715  GLU A OE1 1 
ATOM   3241 O  OE2 . GLU A 1 452 ? -5.882  -55.557 -37.366 1.00 60.43  ? 715  GLU A OE2 1 
ATOM   3242 N  N   . LEU A 1 453 ? -9.636  -57.650 -33.784 1.00 34.95  ? 716  LEU A N   1 
ATOM   3243 C  CA  . LEU A 1 453 ? -10.093 -58.998 -33.400 1.00 37.58  ? 716  LEU A CA  1 
ATOM   3244 C  C   . LEU A 1 453 ? -10.889 -59.575 -34.567 1.00 37.89  ? 716  LEU A C   1 
ATOM   3245 O  O   . LEU A 1 453 ? -11.828 -58.909 -35.057 1.00 39.71  ? 716  LEU A O   1 
ATOM   3246 C  CB  . LEU A 1 453 ? -10.879 -58.815 -32.111 1.00 41.13  ? 716  LEU A CB  1 
ATOM   3247 C  CG  . LEU A 1 453 ? -11.613 -60.024 -31.582 1.00 46.20  ? 716  LEU A CG  1 
ATOM   3248 C  CD1 . LEU A 1 453 ? -10.631 -61.134 -31.306 1.00 52.85  ? 716  LEU A CD1 1 
ATOM   3249 C  CD2 . LEU A 1 453 ? -12.374 -59.649 -30.313 1.00 47.21  ? 716  LEU A CD2 1 
ATOM   3250 N  N   . ILE A 1 454 ? -10.429 -60.713 -35.071 1.00 37.27  ? 717  ILE A N   1 
ATOM   3251 C  CA  . ILE A 1 454 ? -10.972 -61.325 -36.317 1.00 39.59  ? 717  ILE A CA  1 
ATOM   3252 C  C   . ILE A 1 454 ? -11.987 -62.398 -35.907 1.00 40.37  ? 717  ILE A C   1 
ATOM   3253 O  O   . ILE A 1 454 ? -11.653 -63.289 -35.106 1.00 37.00  ? 717  ILE A O   1 
ATOM   3254 C  CB  . ILE A 1 454 ? -9.816  -61.846 -37.190 1.00 45.54  ? 717  ILE A CB  1 
ATOM   3255 C  CG1 . ILE A 1 454 ? -8.684  -60.808 -37.258 1.00 48.41  ? 717  ILE A CG1 1 
ATOM   3256 C  CG2 . ILE A 1 454 ? -10.329 -62.260 -38.563 1.00 47.63  ? 717  ILE A CG2 1 
ATOM   3257 C  CD1 . ILE A 1 454 ? -8.067  -60.598 -38.615 1.00 50.49  ? 717  ILE A CD1 1 
ATOM   3258 N  N   . MET A 1 455 ? -13.214 -62.298 -36.423 0.50 40.89  ? 718  MET A N   1 
ATOM   3259 C  CA  . MET A 1 455 ? -14.294 -63.295 -36.191 0.50 43.10  ? 718  MET A CA  1 
ATOM   3260 C  C   . MET A 1 455 ? -14.037 -64.527 -37.068 0.50 41.45  ? 718  MET A C   1 
ATOM   3261 O  O   . MET A 1 455 ? -13.447 -64.366 -38.145 0.50 39.49  ? 718  MET A O   1 
ATOM   3262 C  CB  . MET A 1 455 ? -15.665 -62.710 -36.538 0.50 43.67  ? 718  MET A CB  1 
ATOM   3263 C  CG  . MET A 1 455 ? -15.926 -61.369 -35.893 0.50 45.47  ? 718  MET A CG  1 
ATOM   3264 S  SD  . MET A 1 455 ? -17.508 -60.673 -36.411 0.50 44.44  ? 718  MET A SD  1 
ATOM   3265 C  CE  . MET A 1 455 ? -18.622 -61.935 -35.801 0.50 43.76  ? 718  MET A CE  1 
ATOM   3266 N  N   A LYS A 1 456 ? -14.480 -65.703 -36.624 0.25 42.59  ? 719  LYS A N   1 
ATOM   3267 N  N   B LYS A 1 456 ? -14.509 -65.694 -36.628 0.25 44.54  ? 719  LYS A N   1 
ATOM   3268 C  CA  A LYS A 1 456 ? -14.364 -66.983 -37.374 0.25 45.63  ? 719  LYS A CA  1 
ATOM   3269 C  CA  B LYS A 1 456 ? -14.370 -66.981 -37.362 0.25 48.59  ? 719  LYS A CA  1 
ATOM   3270 C  C   A LYS A 1 456 ? -14.668 -66.748 -38.862 0.25 44.63  ? 719  LYS A C   1 
ATOM   3271 C  C   B LYS A 1 456 ? -14.688 -66.766 -38.850 0.25 46.56  ? 719  LYS A C   1 
ATOM   3272 O  O   A LYS A 1 456 ? -14.030 -67.408 -39.696 0.25 45.26  ? 719  LYS A O   1 
ATOM   3273 O  O   B LYS A 1 456 ? -14.074 -67.452 -39.678 0.25 47.04  ? 719  LYS A O   1 
ATOM   3274 C  CB  A LYS A 1 456 ? -15.303 -68.025 -36.758 0.25 45.91  ? 719  LYS A CB  1 
ATOM   3275 C  CB  B LYS A 1 456 ? -15.266 -68.046 -36.721 0.25 50.75  ? 719  LYS A CB  1 
ATOM   3276 C  CG  A LYS A 1 456 ? -15.006 -68.361 -35.303 0.25 46.60  ? 719  LYS A CG  1 
ATOM   3277 C  CG  B LYS A 1 456 ? -14.910 -69.480 -37.086 0.25 54.18  ? 719  LYS A CG  1 
ATOM   3278 C  CD  A LYS A 1 456 ? -16.221 -68.829 -34.535 0.25 48.16  ? 719  LYS A CD  1 
ATOM   3279 C  CD  B LYS A 1 456 ? -15.192 -70.492 -35.994 0.25 55.15  ? 719  LYS A CD  1 
ATOM   3280 C  CE  A LYS A 1 456 ? -15.985 -68.910 -33.041 0.25 49.86  ? 719  LYS A CE  1 
ATOM   3281 C  CE  B LYS A 1 456 ? -15.461 -71.880 -36.537 0.25 55.67  ? 719  LYS A CE  1 
ATOM   3282 N  NZ  A LYS A 1 456 ? -16.943 -69.841 -32.396 0.25 49.08  ? 719  LYS A NZ  1 
ATOM   3283 N  NZ  B LYS A 1 456 ? -14.682 -72.910 -35.810 0.25 56.39  ? 719  LYS A NZ  1 
ATOM   3284 N  N   . ASP A 1 457 ? -15.576 -65.820 -39.181 0.50 45.74  ? 720  ASP A N   1 
ATOM   3285 C  CA  . ASP A 1 457 ? -16.064 -65.552 -40.564 0.50 47.01  ? 720  ASP A CA  1 
ATOM   3286 C  C   . ASP A 1 457 ? -15.212 -64.479 -41.262 0.50 49.42  ? 720  ASP A C   1 
ATOM   3287 O  O   . ASP A 1 457 ? -15.631 -64.017 -42.350 0.50 47.17  ? 720  ASP A O   1 
ATOM   3288 C  CB  . ASP A 1 457 ? -17.533 -65.122 -40.549 0.50 48.18  ? 720  ASP A CB  1 
ATOM   3289 C  CG  . ASP A 1 457 ? -17.789 -63.861 -39.740 0.50 50.45  ? 720  ASP A CG  1 
ATOM   3290 O  OD1 . ASP A 1 457 ? -16.968 -62.922 -39.838 0.50 50.82  ? 720  ASP A OD1 1 
ATOM   3291 O  OD2 . ASP A 1 457 ? -18.806 -63.824 -39.019 0.50 51.52  ? 720  ASP A OD2 1 
ATOM   3292 N  N   . GLY A 1 458 ? -14.080 -64.075 -40.668 1.00 50.71  ? 721  GLY A N   1 
ATOM   3293 C  CA  . GLY A 1 458 ? -13.149 -63.120 -41.295 1.00 47.50  ? 721  GLY A CA  1 
ATOM   3294 C  C   . GLY A 1 458 ? -13.480 -61.662 -41.021 1.00 48.33  ? 721  GLY A C   1 
ATOM   3295 O  O   . GLY A 1 458 ? -12.578 -60.814 -41.181 1.00 51.64  ? 721  GLY A O   1 
ATOM   3296 N  N   . ARG A 1 459 ? -14.703 -61.320 -40.617 1.00 45.57  ? 722  ARG A N   1 
ATOM   3297 C  CA  . ARG A 1 459 ? -15.036 -59.887 -40.414 1.00 42.57  ? 722  ARG A CA  1 
ATOM   3298 C  C   . ARG A 1 459 ? -14.224 -59.356 -39.213 1.00 42.31  ? 722  ARG A C   1 
ATOM   3299 O  O   . ARG A 1 459 ? -13.859 -60.132 -38.288 1.00 40.62  ? 722  ARG A O   1 
ATOM   3300 C  CB  . ARG A 1 459 ? -16.550 -59.736 -40.265 1.00 43.97  ? 722  ARG A CB  1 
ATOM   3301 C  CG  . ARG A 1 459 ? -17.359 -60.155 -41.483 1.00 40.36  ? 722  ARG A CG  1 
ATOM   3302 C  CD  . ARG A 1 459 ? -18.838 -59.795 -41.326 1.00 38.41  ? 722  ARG A CD  1 
ATOM   3303 N  NE  . ARG A 1 459 ? -19.459 -60.664 -40.346 1.00 38.09  ? 722  ARG A NE  1 
ATOM   3304 C  CZ  . ARG A 1 459 ? -20.744 -60.677 -40.033 1.00 40.92  ? 722  ARG A CZ  1 
ATOM   3305 N  NH1 . ARG A 1 459 ? -21.586 -59.864 -40.643 1.00 43.67  ? 722  ARG A NH1 1 
ATOM   3306 N  NH2 . ARG A 1 459 ? -21.182 -61.517 -39.109 1.00 41.70  ? 722  ARG A NH2 1 
ATOM   3307 N  N   . VAL A 1 460 ? -13.939 -58.066 -39.218 1.00 38.32  ? 723  VAL A N   1 
ATOM   3308 C  CA  . VAL A 1 460 ? -12.983 -57.445 -38.265 1.00 35.56  ? 723  VAL A CA  1 
ATOM   3309 C  C   . VAL A 1 460 ? -13.721 -56.588 -37.236 1.00 33.35  ? 723  VAL A C   1 
ATOM   3310 O  O   . VAL A 1 460 ? -14.449 -55.660 -37.604 1.00 36.84  ? 723  VAL A O   1 
ATOM   3311 C  CB  . VAL A 1 460 ? -11.898 -56.660 -39.014 1.00 39.61  ? 723  VAL A CB  1 
ATOM   3312 C  CG1 . VAL A 1 460 ? -10.878 -56.085 -38.038 1.00 45.62  ? 723  VAL A CG1 1 
ATOM   3313 C  CG2 . VAL A 1 460 ? -11.179 -57.559 -40.015 1.00 39.82  ? 723  VAL A CG2 1 
ATOM   3314 N  N   . LEU A 1 461 ? -13.524 -56.898 -35.957 1.00 32.75  ? 724  LEU A N   1 
ATOM   3315 C  CA  . LEU A 1 461 ? -14.017 -56.060 -34.846 1.00 30.40  ? 724  LEU A CA  1 
ATOM   3316 C  C   . LEU A 1 461 ? -12.827 -55.276 -34.281 1.00 34.73  ? 724  LEU A C   1 
ATOM   3317 O  O   . LEU A 1 461 ? -11.736 -55.847 -34.093 1.00 38.53  ? 724  LEU A O   1 
ATOM   3318 C  CB  . LEU A 1 461 ? -14.618 -56.976 -33.792 1.00 31.26  ? 724  LEU A CB  1 
ATOM   3319 C  CG  . LEU A 1 461 ? -15.804 -57.828 -34.228 1.00 26.73  ? 724  LEU A CG  1 
ATOM   3320 C  CD1 . LEU A 1 461 ? -16.172 -58.735 -33.093 1.00 29.82  ? 724  LEU A CD1 1 
ATOM   3321 C  CD2 . LEU A 1 461 ? -16.970 -56.995 -34.635 1.00 24.84  ? 724  LEU A CD2 1 
ATOM   3322 N  N   . VAL A 1 462 ? -13.015 -53.996 -34.031 1.00 31.64  ? 725  VAL A N   1 
ATOM   3323 C  CA  . VAL A 1 462 ? -12.028 -53.183 -33.283 1.00 28.16  ? 725  VAL A CA  1 
ATOM   3324 C  C   . VAL A 1 462 ? -12.702 -52.865 -31.964 1.00 27.18  ? 725  VAL A C   1 
ATOM   3325 O  O   . VAL A 1 462 ? -13.750 -52.213 -32.011 1.00 27.79  ? 725  VAL A O   1 
ATOM   3326 C  CB  . VAL A 1 462 ? -11.599 -51.913 -34.019 1.00 28.12  ? 725  VAL A CB  1 
ATOM   3327 C  CG1 . VAL A 1 462 ? -10.723 -51.046 -33.107 1.00 29.25  ? 725  VAL A CG1 1 
ATOM   3328 C  CG2 . VAL A 1 462 ? -10.889 -52.248 -35.315 1.00 27.35  ? 725  VAL A CG2 1 
ATOM   3329 N  N   . VAL A 1 463 ? -12.171 -53.419 -30.875 1.00 27.29  ? 726  VAL A N   1 
ATOM   3330 C  CA  . VAL A 1 463 ? -12.902 -53.534 -29.591 1.00 26.19  ? 726  VAL A CA  1 
ATOM   3331 C  C   . VAL A 1 463 ? -12.169 -52.709 -28.548 1.00 26.47  ? 726  VAL A C   1 
ATOM   3332 O  O   . VAL A 1 463 ? -10.938 -52.684 -28.530 1.00 29.72  ? 726  VAL A O   1 
ATOM   3333 C  CB  . VAL A 1 463 ? -13.024 -54.987 -29.126 1.00 27.44  ? 726  VAL A CB  1 
ATOM   3334 C  CG1 . VAL A 1 463 ? -13.908 -55.789 -30.058 1.00 29.10  ? 726  VAL A CG1 1 
ATOM   3335 C  CG2 . VAL A 1 463 ? -11.658 -55.642 -28.967 1.00 29.30  ? 726  VAL A CG2 1 
ATOM   3336 N  N   . PRO A 1 464 ? -12.897 -52.037 -27.630 0.50 25.64  ? 727  PRO A N   1 
ATOM   3337 C  CA  . PRO A 1 464 ? -12.270 -51.288 -26.546 0.50 25.12  ? 727  PRO A CA  1 
ATOM   3338 C  C   . PRO A 1 464 ? -11.851 -52.209 -25.395 0.50 25.29  ? 727  PRO A C   1 
ATOM   3339 O  O   . PRO A 1 464 ? -12.501 -53.227 -25.185 0.50 23.87  ? 727  PRO A O   1 
ATOM   3340 C  CB  . PRO A 1 464 ? -13.402 -50.366 -26.091 0.50 25.21  ? 727  PRO A CB  1 
ATOM   3341 C  CG  . PRO A 1 464 ? -14.637 -51.222 -26.285 0.50 25.34  ? 727  PRO A CG  1 
ATOM   3342 C  CD  . PRO A 1 464 ? -14.367 -51.985 -27.568 0.50 25.32  ? 727  PRO A CD  1 
ATOM   3343 N  N   . CYS A 1 465 ? -10.803 -51.813 -24.669 1.00 25.80  ? 728  CYS A N   1 
ATOM   3344 C  CA  . CYS A 1 465 ? -10.207 -52.613 -23.586 1.00 24.44  ? 728  CYS A CA  1 
ATOM   3345 C  C   . CYS A 1 465 ? -9.580  -51.697 -22.535 1.00 26.23  ? 728  CYS A C   1 
ATOM   3346 O  O   . CYS A 1 465 ? -9.101  -50.641 -22.915 1.00 24.66  ? 728  CYS A O   1 
ATOM   3347 C  CB  . CYS A 1 465 ? -9.184  -53.582 -24.168 1.00 24.80  ? 728  CYS A CB  1 
ATOM   3348 S  SG  . CYS A 1 465 ? -8.793  -54.938 -23.021 1.00 25.63  ? 728  CYS A SG  1 
ATOM   3349 N  N   . ARG A 1 466 ? -9.557  -52.133 -21.271 1.00 25.67  ? 729  ARG A N   1 
ATOM   3350 C  CA  . ARG A 1 466 ? -8.632  -51.622 -20.251 1.00 26.97  ? 729  ARG A CA  1 
ATOM   3351 C  C   . ARG A 1 466 ? -8.391  -52.702 -19.198 1.00 26.80  ? 729  ARG A C   1 
ATOM   3352 O  O   . ARG A 1 466 ? -9.037  -53.778 -19.238 1.00 28.95  ? 729  ARG A O   1 
ATOM   3353 C  CB  . ARG A 1 466 ? -9.166  -50.343 -19.632 1.00 29.58  ? 729  ARG A CB  1 
ATOM   3354 C  CG  . ARG A 1 466 ? -10.522 -50.510 -18.995 1.00 34.08  ? 729  ARG A CG  1 
ATOM   3355 C  CD  . ARG A 1 466 ? -11.231 -49.201 -18.741 1.00 34.10  ? 729  ARG A CD  1 
ATOM   3356 N  NE  . ARG A 1 466 ? -10.677 -48.478 -17.607 1.00 32.72  ? 729  ARG A NE  1 
ATOM   3357 C  CZ  . ARG A 1 466 ? -11.191 -47.342 -17.152 1.00 36.52  ? 729  ARG A CZ  1 
ATOM   3358 N  NH1 . ARG A 1 466 ? -12.278 -46.804 -17.699 1.00 39.42  ? 729  ARG A NH1 1 
ATOM   3359 N  NH2 . ARG A 1 466 ? -10.607 -46.731 -16.157 1.00 36.87  ? 729  ARG A NH2 1 
ATOM   3360 N  N   . ASN A 1 467 ? -7.442  -52.433 -18.313 1.00 31.33  ? 730  ASN A N   1 
ATOM   3361 C  CA  . ASN A 1 467 ? -7.066  -53.358 -17.220 1.00 30.59  ? 730  ASN A CA  1 
ATOM   3362 C  C   . ASN A 1 467 ? -8.356  -53.802 -16.516 1.00 28.76  ? 730  ASN A C   1 
ATOM   3363 O  O   . ASN A 1 467 ? -9.116  -52.981 -16.063 1.00 29.91  ? 730  ASN A O   1 
ATOM   3364 C  CB  . ASN A 1 467 ? -6.036  -52.809 -16.241 1.00 28.81  ? 730  ASN A CB  1 
ATOM   3365 C  CG  . ASN A 1 467 ? -5.794  -53.859 -15.175 1.00 32.52  ? 730  ASN A CG  1 
ATOM   3366 O  OD1 . ASN A 1 467 ? -6.536  -53.927 -14.216 1.00 31.95  ? 730  ASN A OD1 1 
ATOM   3367 N  ND2 . ASN A 1 467 ? -4.879  -54.793 -15.405 1.00 38.82  ? 730  ASN A ND2 1 
ATOM   3368 N  N   . GLN A 1 468 ? -8.550  -55.102 -16.440 1.00 30.66  ? 731  GLN A N   1 
ATOM   3369 C  CA  . GLN A 1 468 ? -9.839  -55.681 -16.032 1.00 32.53  ? 731  GLN A CA  1 
ATOM   3370 C  C   . GLN A 1 468 ? -10.032 -55.403 -14.545 1.00 30.33  ? 731  GLN A C   1 
ATOM   3371 O  O   . GLN A 1 468 ? -11.183 -55.372 -14.123 1.00 26.51  ? 731  GLN A O   1 
ATOM   3372 C  CB  . GLN A 1 468 ? -9.913  -57.156 -16.405 1.00 29.89  ? 731  GLN A CB  1 
ATOM   3373 C  CG  . GLN A 1 468 ? -11.253 -57.793 -16.076 1.00 27.91  ? 731  GLN A CG  1 
ATOM   3374 C  CD  . GLN A 1 468 ? -11.177 -59.267 -16.360 1.00 27.70  ? 731  GLN A CD  1 
ATOM   3375 O  OE1 . GLN A 1 468 ? -11.418 -59.691 -17.489 1.00 28.67  ? 731  GLN A OE1 1 
ATOM   3376 N  NE2 . GLN A 1 468 ? -10.841 -60.056 -15.343 1.00 26.08  ? 731  GLN A NE2 1 
ATOM   3377 N  N   . ASP A 1 469 ? -8.970  -55.147 -13.792 1.00 30.80  ? 732  ASP A N   1 
ATOM   3378 C  CA  . ASP A 1 469 ? -9.159  -54.772 -12.360 1.00 32.19  ? 732  ASP A CA  1 
ATOM   3379 C  C   . ASP A 1 469 ? -9.930  -53.452 -12.286 1.00 31.63  ? 732  ASP A C   1 
ATOM   3380 O  O   . ASP A 1 469 ? -10.712 -53.310 -11.359 1.00 29.02  ? 732  ASP A O   1 
ATOM   3381 C  CB  . ASP A 1 469 ? -7.854  -54.679 -11.573 1.00 33.45  ? 732  ASP A CB  1 
ATOM   3382 C  CG  . ASP A 1 469 ? -7.134  -56.016 -11.432 1.00 38.05  ? 732  ASP A CG  1 
ATOM   3383 O  OD1 . ASP A 1 469 ? -7.802  -57.097 -11.522 1.00 36.00  ? 732  ASP A OD1 1 
ATOM   3384 O  OD2 . ASP A 1 469 ? -5.919  -55.968 -11.228 1.00 40.66  ? 732  ASP A OD2 1 
ATOM   3385 N  N   . GLU A 1 470 ? -9.686  -52.517 -13.208 1.00 29.73  ? 733  GLU A N   1 
ATOM   3386 C  CA  . GLU A 1 470 ? -10.376 -51.205 -13.239 1.00 28.19  ? 733  GLU A CA  1 
ATOM   3387 C  C   . GLU A 1 470 ? -11.874 -51.443 -13.506 1.00 28.59  ? 733  GLU A C   1 
ATOM   3388 O  O   . GLU A 1 470 ? -12.698 -50.833 -12.798 1.00 32.53  ? 733  GLU A O   1 
ATOM   3389 C  CB  . GLU A 1 470 ? -9.784  -50.302 -14.317 1.00 29.68  ? 733  GLU A CB  1 
ATOM   3390 C  CG  . GLU A 1 470 ? -8.301  -50.002 -14.107 1.00 34.27  ? 733  GLU A CG  1 
ATOM   3391 C  CD  . GLU A 1 470 ? -7.636  -49.170 -15.188 1.00 35.30  ? 733  GLU A CD  1 
ATOM   3392 O  OE1 . GLU A 1 470 ? -6.403  -49.028 -15.127 1.00 44.03  ? 733  GLU A OE1 1 
ATOM   3393 O  OE2 . GLU A 1 470 ? -8.340  -48.677 -16.098 1.00 38.13  ? 733  GLU A OE2 1 
ATOM   3394 N  N   . LEU A 1 471 ? -12.213 -52.302 -14.469 1.00 24.72  ? 734  LEU A N   1 
ATOM   3395 C  CA  . LEU A 1 471 ? -13.609 -52.600 -14.875 1.00 25.45  ? 734  LEU A CA  1 
ATOM   3396 C  C   . LEU A 1 471 ? -14.384 -53.214 -13.699 1.00 26.92  ? 734  LEU A C   1 
ATOM   3397 O  O   . LEU A 1 471 ? -15.450 -52.669 -13.327 1.00 28.80  ? 734  LEU A O   1 
ATOM   3398 C  CB  . LEU A 1 471 ? -13.556 -53.492 -16.122 1.00 28.30  ? 734  LEU A CB  1 
ATOM   3399 C  CG  . LEU A 1 471 ? -13.025 -52.766 -17.366 1.00 29.69  ? 734  LEU A CG  1 
ATOM   3400 C  CD1 . LEU A 1 471 ? -13.053 -53.630 -18.613 1.00 29.66  ? 734  LEU A CD1 1 
ATOM   3401 C  CD2 . LEU A 1 471 ? -13.831 -51.515 -17.620 1.00 33.77  ? 734  LEU A CD2 1 
ATOM   3402 N  N   . ILE A 1 472 ? -13.838 -54.242 -13.059 1.00 27.84  ? 735  ILE A N   1 
ATOM   3403 C  CA  . ILE A 1 472 ? -14.476 -54.933 -11.901 1.00 26.58  ? 735  ILE A CA  1 
ATOM   3404 C  C   . ILE A 1 472 ? -14.545 -54.013 -10.666 1.00 28.34  ? 735  ILE A C   1 
ATOM   3405 O  O   . ILE A 1 472 ? -15.636 -53.965 -10.042 1.00 26.38  ? 735  ILE A O   1 
ATOM   3406 C  CB  . ILE A 1 472 ? -13.769 -56.263 -11.657 1.00 27.13  ? 735  ILE A CB  1 
ATOM   3407 C  CG1 . ILE A 1 472 ? -13.966 -57.144 -12.891 1.00 31.26  ? 735  ILE A CG1 1 
ATOM   3408 C  CG2 . ILE A 1 472 ? -14.295 -56.930 -10.400 1.00 28.68  ? 735  ILE A CG2 1 
ATOM   3409 C  CD1 . ILE A 1 472 ? -13.344 -58.493 -12.788 1.00 33.11  ? 735  ILE A CD1 1 
ATOM   3410 N  N   . GLY A 1 473 ? -13.485 -53.265 -10.337 1.00 24.77  ? 736  GLY A N   1 
ATOM   3411 C  CA  . GLY A 1 473 ? -13.511 -52.300 -9.213  1.00 28.02  ? 736  GLY A CA  1 
ATOM   3412 C  C   . GLY A 1 473 ? -14.591 -51.210 -9.378  1.00 31.86  ? 736  GLY A C   1 
ATOM   3413 O  O   . GLY A 1 473 ? -15.231 -50.849 -8.358  1.00 30.34  ? 736  GLY A O   1 
ATOM   3414 N  N   . ARG A 1 474 ? -14.835 -50.720 -10.606 1.00 28.49  ? 737  ARG A N   1 
ATOM   3415 C  CA  . ARG A 1 474 ? -15.834 -49.650 -10.871 1.00 31.24  ? 737  ARG A CA  1 
ATOM   3416 C  C   . ARG A 1 474 ? -17.242 -50.231 -10.692 1.00 30.49  ? 737  ARG A C   1 
ATOM   3417 O  O   . ARG A 1 474 ? -18.088 -49.545 -10.097 1.00 36.12  ? 737  ARG A O   1 
ATOM   3418 C  CB  . ARG A 1 474 ? -15.694 -49.073 -12.292 1.00 34.36  ? 737  ARG A CB  1 
ATOM   3419 C  CG  . ARG A 1 474 ? -14.297 -48.550 -12.603 1.00 47.73  ? 737  ARG A CG  1 
ATOM   3420 C  CD  . ARG A 1 474 ? -13.999 -48.137 -14.045 1.00 53.66  ? 737  ARG A CD  1 
ATOM   3421 N  NE  . ARG A 1 474 ? -14.455 -46.756 -14.167 1.00 64.34  ? 737  ARG A NE  1 
ATOM   3422 C  CZ  . ARG A 1 474 ? -13.795 -45.681 -13.731 1.00 64.60  ? 737  ARG A CZ  1 
ATOM   3423 N  NH1 . ARG A 1 474 ? -14.350 -44.487 -13.878 1.00 68.08  ? 737  ARG A NH1 1 
ATOM   3424 N  NH2 . ARG A 1 474 ? -12.591 -45.790 -13.180 1.00 61.94  ? 737  ARG A NH2 1 
ATOM   3425 N  N   . ALA A 1 475 ? -17.521 -51.406 -11.263 1.00 27.62  ? 738  ALA A N   1 
ATOM   3426 C  CA  . ALA A 1 475 ? -18.855 -52.039 -11.211 1.00 27.30  ? 738  ALA A CA  1 
ATOM   3427 C  C   . ALA A 1 475 ? -19.224 -52.365 -9.749  1.00 27.72  ? 738  ALA A C   1 
ATOM   3428 O  O   . ALA A 1 475 ? -20.417 -52.465 -9.452  1.00 30.69  ? 738  ALA A O   1 
ATOM   3429 C  CB  . ALA A 1 475 ? -18.889 -53.281 -12.072 1.00 26.29  ? 738  ALA A CB  1 
ATOM   3430 N  N   . ARG A 1 476 ? -18.247 -52.551 -8.867  1.00 27.62  ? 739  ARG A N   1 
ATOM   3431 C  CA  . ARG A 1 476 ? -18.501 -52.929 -7.444  1.00 32.48  ? 739  ARG A CA  1 
ATOM   3432 C  C   . ARG A 1 476 ? -18.844 -51.675 -6.615  1.00 32.32  ? 739  ARG A C   1 
ATOM   3433 O  O   . ARG A 1 476 ? -19.094 -51.799 -5.398  1.00 31.03  ? 739  ARG A O   1 
ATOM   3434 C  CB  . ARG A 1 476 ? -17.299 -53.718 -6.900  1.00 29.44  ? 739  ARG A CB  1 
ATOM   3435 C  CG  . ARG A 1 476 ? -17.257 -55.152 -7.411  1.00 29.82  ? 739  ARG A CG  1 
ATOM   3436 C  CD  . ARG A 1 476 ? -15.919 -55.881 -7.283  1.00 31.08  ? 739  ARG A CD  1 
ATOM   3437 N  NE  . ARG A 1 476 ? -15.509 -56.154 -5.900  1.00 29.76  ? 739  ARG A NE  1 
ATOM   3438 C  CZ  . ARG A 1 476 ? -15.244 -57.346 -5.377  1.00 27.37  ? 739  ARG A CZ  1 
ATOM   3439 N  NH1 . ARG A 1 476 ? -15.353 -58.451 -6.077  1.00 29.12  ? 739  ARG A NH1 1 
ATOM   3440 N  NH2 . ARG A 1 476 ? -14.820 -57.440 -4.137  1.00 29.44  ? 739  ARG A NH2 1 
ATOM   3441 N  N   . ILE A 1 477 ? -18.859 -50.506 -7.238  1.00 34.23  ? 740  ILE A N   1 
ATOM   3442 C  CA  . ILE A 1 477 ? -19.114 -49.222 -6.526  1.00 48.24  ? 740  ILE A CA  1 
ATOM   3443 C  C   . ILE A 1 477 ? -20.431 -48.618 -7.002  1.00 52.16  ? 740  ILE A C   1 
ATOM   3444 O  O   . ILE A 1 477 ? -20.662 -48.519 -8.229  1.00 43.86  ? 740  ILE A O   1 
ATOM   3445 C  CB  . ILE A 1 477 ? -17.963 -48.223 -6.715  1.00 47.13  ? 740  ILE A CB  1 
ATOM   3446 C  CG1 . ILE A 1 477 ? -16.677 -48.741 -6.062  1.00 47.17  ? 740  ILE A CG1 1 
ATOM   3447 C  CG2 . ILE A 1 477 ? -18.379 -46.876 -6.149  1.00 48.42  ? 740  ILE A CG2 1 
ATOM   3448 C  CD1 . ILE A 1 477 ? -15.436 -47.941 -6.387  1.00 44.92  ? 740  ILE A CD1 1 
ATOM   3449 N  N   A SER A 1 478 ? -21.272 -48.227 -6.041  0.20 57.44  ? 741  SER A N   1 
ATOM   3450 N  N   B SER A 1 478 ? -21.290 -48.234 -6.051  0.20 56.41  ? 741  SER A N   1 
ATOM   3451 C  CA  A SER A 1 478 ? -22.523 -47.455 -6.257  0.20 65.35  ? 741  SER A CA  1 
ATOM   3452 C  CA  B SER A 1 478 ? -22.538 -47.461 -6.299  0.20 63.53  ? 741  SER A CA  1 
ATOM   3453 C  C   A SER A 1 478 ? -22.305 -46.010 -5.797  0.20 72.66  ? 741  SER A C   1 
ATOM   3454 C  C   B SER A 1 478 ? -22.368 -46.030 -5.771  0.20 71.61  ? 741  SER A C   1 
ATOM   3455 O  O   A SER A 1 478 ? -21.560 -45.806 -4.811  0.20 75.40  ? 741  SER A O   1 
ATOM   3456 O  O   B SER A 1 478 ? -21.722 -45.856 -4.711  0.20 75.24  ? 741  SER A O   1 
ATOM   3457 C  CB  A SER A 1 478 ? -23.691 -48.088 -5.548  0.20 63.59  ? 741  SER A CB  1 
ATOM   3458 C  CB  B SER A 1 478 ? -23.765 -48.140 -5.720  0.20 60.39  ? 741  SER A CB  1 
ATOM   3459 O  OG  A SER A 1 478 ? -24.788 -47.189 -5.489  0.20 63.79  ? 741  SER A OG  1 
ATOM   3460 O  OG  B SER A 1 478 ? -23.422 -49.109 -4.741  0.20 58.62  ? 741  SER A OG  1 
ATOM   3461 N  N   . GLN A 1 479 ? -22.916 -45.055 -6.506  1.00 81.57  ? 742  GLN A N   1 
ATOM   3462 C  CA  . GLN A 1 479 ? -22.873 -43.611 -6.148  1.00 91.93  ? 742  GLN A CA  1 
ATOM   3463 C  C   . GLN A 1 479 ? -24.185 -43.272 -5.450  1.00 94.03  ? 742  GLN A C   1 
ATOM   3464 O  O   . GLN A 1 479 ? -25.209 -43.199 -6.144  1.00 96.41  ? 742  GLN A O   1 
ATOM   3465 C  CB  . GLN A 1 479 ? -22.644 -42.729 -7.378  1.00 101.49 ? 742  GLN A CB  1 
ATOM   3466 C  CG  . GLN A 1 479 ? -21.177 -42.645 -7.793  1.00 117.34 ? 742  GLN A CG  1 
ATOM   3467 C  CD  . GLN A 1 479 ? -20.228 -42.413 -6.635  1.00 122.77 ? 742  GLN A CD  1 
ATOM   3468 O  OE1 . GLN A 1 479 ? -20.386 -41.471 -5.860  1.00 120.63 ? 742  GLN A OE1 1 
ATOM   3469 N  NE2 . GLN A 1 479 ? -19.225 -43.271 -6.505  1.00 121.56 ? 742  GLN A NE2 1 
ATOM   3470 N  N   . GLY A 1 480 ? -24.125 -43.128 -4.125  1.00 95.87  ? 743  GLY A N   1 
ATOM   3471 C  CA  . GLY A 1 480 ? -25.227 -42.632 -3.287  1.00 98.81  ? 743  GLY A CA  1 
ATOM   3472 C  C   . GLY A 1 480 ? -25.622 -43.633 -2.221  1.00 94.61  ? 743  GLY A C   1 
ATOM   3473 O  O   . GLY A 1 480 ? -25.098 -44.762 -2.225  1.00 94.81  ? 743  GLY A O   1 
ATOM   3474 N  N   . ALA A 1 481 ? -26.521 -43.197 -1.341  1.00 93.75  ? 744  ALA A N   1 
ATOM   3475 C  CA  . ALA A 1 481 ? -27.146 -43.976 -0.255  1.00 88.34  ? 744  ALA A CA  1 
ATOM   3476 C  C   . ALA A 1 481 ? -28.667 -43.997 -0.477  1.00 75.48  ? 744  ALA A C   1 
ATOM   3477 O  O   . ALA A 1 481 ? -29.150 -43.275 -1.387  1.00 53.12  ? 744  ALA A O   1 
ATOM   3478 C  CB  . ALA A 1 481 ? -26.776 -43.346 1.064   1.00 100.39 ? 744  ALA A CB  1 
ATOM   3479 N  N   . GLY A 1 482 ? -29.379 -44.800 0.329   1.00 64.02  ? 745  GLY A N   1 
ATOM   3480 C  CA  . GLY A 1 482 ? -30.838 -45.027 0.268   1.00 54.95  ? 745  GLY A CA  1 
ATOM   3481 C  C   . GLY A 1 482 ? -31.253 -45.939 -0.873  1.00 53.67  ? 745  GLY A C   1 
ATOM   3482 O  O   . GLY A 1 482 ? -32.434 -45.903 -1.270  1.00 57.44  ? 745  GLY A O   1 
ATOM   3483 N  N   . TRP A 1 483 ? -30.330 -46.756 -1.389  0.40 52.30  ? 746  TRP A N   1 
ATOM   3484 C  CA  . TRP A 1 483 ? -30.590 -47.652 -2.547  0.40 49.98  ? 746  TRP A CA  1 
ATOM   3485 C  C   . TRP A 1 483 ? -31.300 -48.927 -2.084  0.40 47.81  ? 746  TRP A C   1 
ATOM   3486 O  O   . TRP A 1 483 ? -30.794 -49.604 -1.168  0.40 48.17  ? 746  TRP A O   1 
ATOM   3487 C  CB  . TRP A 1 483 ? -29.293 -47.953 -3.296  0.40 51.85  ? 746  TRP A CB  1 
ATOM   3488 C  CG  . TRP A 1 483 ? -28.948 -46.885 -4.284  0.40 53.31  ? 746  TRP A CG  1 
ATOM   3489 C  CD1 . TRP A 1 483 ? -28.821 -45.549 -4.032  0.40 54.83  ? 746  TRP A CD1 1 
ATOM   3490 C  CD2 . TRP A 1 483 ? -28.703 -47.054 -5.691  0.40 53.46  ? 746  TRP A CD2 1 
ATOM   3491 N  NE1 . TRP A 1 483 ? -28.505 -44.876 -5.180  0.40 55.18  ? 746  TRP A NE1 1 
ATOM   3492 C  CE2 . TRP A 1 483 ? -28.425 -45.773 -6.215  0.40 56.09  ? 746  TRP A CE2 1 
ATOM   3493 C  CE3 . TRP A 1 483 ? -28.689 -48.155 -6.555  0.40 53.62  ? 746  TRP A CE3 1 
ATOM   3494 C  CZ2 . TRP A 1 483 ? -28.137 -45.570 -7.565  0.40 54.28  ? 746  TRP A CZ2 1 
ATOM   3495 C  CZ3 . TRP A 1 483 ? -28.405 -47.953 -7.887  0.40 54.03  ? 746  TRP A CZ3 1 
ATOM   3496 C  CH2 . TRP A 1 483 ? -28.135 -46.677 -8.383  0.40 54.27  ? 746  TRP A CH2 1 
ATOM   3497 N  N   . SER A 1 484 ? -32.442 -49.234 -2.697  0.40 45.81  ? 747  SER A N   1 
ATOM   3498 C  CA  . SER A 1 484 ? -33.163 -50.517 -2.511  0.40 45.38  ? 747  SER A CA  1 
ATOM   3499 C  C   . SER A 1 484 ? -32.303 -51.639 -3.102  0.40 44.63  ? 747  SER A C   1 
ATOM   3500 O  O   . SER A 1 484 ? -31.393 -51.326 -3.891  0.40 41.79  ? 747  SER A O   1 
ATOM   3501 C  CB  . SER A 1 484 ? -34.531 -50.476 -3.136  0.40 43.76  ? 747  SER A CB  1 
ATOM   3502 O  OG  . SER A 1 484 ? -34.496 -50.970 -4.466  0.40 43.63  ? 747  SER A OG  1 
ATOM   3503 N  N   . LEU A 1 485 ? -32.568 -52.890 -2.717  0.50 45.68  ? 748  LEU A N   1 
ATOM   3504 C  CA  . LEU A 1 485 ? -31.918 -54.086 -3.313  0.50 46.25  ? 748  LEU A CA  1 
ATOM   3505 C  C   . LEU A 1 485 ? -32.211 -54.114 -4.818  0.50 45.56  ? 748  LEU A C   1 
ATOM   3506 O  O   . LEU A 1 485 ? -31.307 -54.485 -5.601  0.50 44.85  ? 748  LEU A O   1 
ATOM   3507 C  CB  . LEU A 1 485 ? -32.446 -55.348 -2.627  0.50 46.83  ? 748  LEU A CB  1 
ATOM   3508 C  CG  . LEU A 1 485 ? -31.825 -56.650 -3.128  0.50 46.71  ? 748  LEU A CG  1 
ATOM   3509 C  CD1 . LEU A 1 485 ? -30.306 -56.553 -3.100  0.50 46.78  ? 748  LEU A CD1 1 
ATOM   3510 C  CD2 . LEU A 1 485 ? -32.307 -57.837 -2.307  0.50 46.15  ? 748  LEU A CD2 1 
ATOM   3511 N  N   . ARG A 1 486 ? -33.431 -53.723 -5.196  0.50 44.10  ? 749  ARG A N   1 
ATOM   3512 C  CA  . ARG A 1 486 ? -33.900 -53.685 -6.605  0.50 44.77  ? 749  ARG A CA  1 
ATOM   3513 C  C   . ARG A 1 486 ? -33.093 -52.643 -7.388  0.50 42.14  ? 749  ARG A C   1 
ATOM   3514 O  O   . ARG A 1 486 ? -32.713 -52.933 -8.537  0.50 41.04  ? 749  ARG A O   1 
ATOM   3515 C  CB  . ARG A 1 486 ? -35.393 -53.354 -6.671  0.50 44.97  ? 749  ARG A CB  1 
ATOM   3516 C  CG  . ARG A 1 486 ? -35.900 -53.173 -8.093  0.50 45.64  ? 749  ARG A CG  1 
ATOM   3517 C  CD  . ARG A 1 486 ? -37.397 -53.371 -8.164  0.50 47.89  ? 749  ARG A CD  1 
ATOM   3518 N  NE  . ARG A 1 486 ? -37.922 -53.230 -9.512  0.50 47.84  ? 749  ARG A NE  1 
ATOM   3519 C  CZ  . ARG A 1 486 ? -39.033 -53.819 -9.929  0.50 48.00  ? 749  ARG A CZ  1 
ATOM   3520 N  NH1 . ARG A 1 486 ? -39.710 -54.587 -9.091  0.50 46.93  ? 749  ARG A NH1 1 
ATOM   3521 N  NH2 . ARG A 1 486 ? -39.454 -53.647 -11.170 0.50 47.24  ? 749  ARG A NH2 1 
ATOM   3522 N  N   . GLU A 1 487 ? -32.875 -51.468 -6.795  0.40 38.69  ? 750  GLU A N   1 
ATOM   3523 C  CA  . GLU A 1 487 ? -32.063 -50.380 -7.396  0.40 40.51  ? 750  GLU A CA  1 
ATOM   3524 C  C   . GLU A 1 487 ? -30.632 -50.893 -7.591  0.40 40.39  ? 750  GLU A C   1 
ATOM   3525 O  O   . GLU A 1 487 ? -30.075 -50.725 -8.702  0.40 37.71  ? 750  GLU A O   1 
ATOM   3526 C  CB  . GLU A 1 487 ? -32.099 -49.136 -6.506  0.40 40.88  ? 750  GLU A CB  1 
ATOM   3527 C  CG  . GLU A 1 487 ? -33.504 -48.603 -6.276  0.40 42.40  ? 750  GLU A CG  1 
ATOM   3528 C  CD  . GLU A 1 487 ? -33.562 -47.337 -5.441  0.40 43.05  ? 750  GLU A CD  1 
ATOM   3529 O  OE1 . GLU A 1 487 ? -34.668 -47.014 -4.944  0.40 45.69  ? 750  GLU A OE1 1 
ATOM   3530 O  OE2 . GLU A 1 487 ? -32.497 -46.679 -5.296  0.40 45.81  ? 750  GLU A OE2 1 
ATOM   3531 N  N   . THR A 1 488 ? -30.070 -51.510 -6.548  0.50 40.67  ? 751  THR A N   1 
ATOM   3532 C  CA  . THR A 1 488 ? -28.690 -52.067 -6.539  0.50 41.49  ? 751  THR A CA  1 
ATOM   3533 C  C   . THR A 1 488 ? -28.576 -53.119 -7.655  0.50 41.67  ? 751  THR A C   1 
ATOM   3534 O  O   . THR A 1 488 ? -27.612 -53.036 -8.443  0.50 42.43  ? 751  THR A O   1 
ATOM   3535 C  CB  . THR A 1 488 ? -28.334 -52.618 -5.153  0.50 40.46  ? 751  THR A CB  1 
ATOM   3536 O  OG1 . THR A 1 488 ? -28.589 -51.579 -4.205  0.50 42.38  ? 751  THR A OG1 1 
ATOM   3537 C  CG2 . THR A 1 488 ? -26.898 -53.085 -5.055  0.50 39.59  ? 751  THR A CG2 1 
ATOM   3538 N  N   . ALA A 1 489 ? -29.534 -54.050 -7.734  0.50 38.58  ? 752  ALA A N   1 
ATOM   3539 C  CA  . ALA A 1 489 ? -29.570 -55.136 -8.743  0.50 38.49  ? 752  ALA A CA  1 
ATOM   3540 C  C   . ALA A 1 489 ? -29.590 -54.526 -10.150 0.50 38.72  ? 752  ALA A C   1 
ATOM   3541 O  O   . ALA A 1 489 ? -28.836 -55.011 -11.010 0.50 38.55  ? 752  ALA A O   1 
ATOM   3542 C  CB  . ALA A 1 489 ? -30.764 -56.032 -8.511  0.50 37.00  ? 752  ALA A CB  1 
ATOM   3543 N  N   . CYS A 1 490 ? -30.414 -53.493 -10.364 0.50 38.04  ? 753  CYS A N   1 
ATOM   3544 C  CA  . CYS A 1 490 ? -30.630 -52.833 -11.680 0.50 37.96  ? 753  CYS A CA  1 
ATOM   3545 C  C   . CYS A 1 490 ? -29.355 -52.087 -12.095 0.50 36.68  ? 753  CYS A C   1 
ATOM   3546 O  O   . CYS A 1 490 ? -29.044 -52.075 -13.295 0.50 35.15  ? 753  CYS A O   1 
ATOM   3547 C  CB  . CYS A 1 490 ? -31.841 -51.905 -11.645 0.50 38.73  ? 753  CYS A CB  1 
ATOM   3548 S  SG  . CYS A 1 490 ? -33.420 -52.796 -11.532 0.50 39.74  ? 753  CYS A SG  1 
ATOM   3549 N  N   . LEU A 1 491 ? -28.620 -51.512 -11.142 0.50 36.23  ? 754  LEU A N   1 
ATOM   3550 C  CA  . LEU A 1 491 ? -27.293 -50.904 -11.429 0.50 37.44  ? 754  LEU A CA  1 
ATOM   3551 C  C   . LEU A 1 491 ? -26.293 -52.008 -11.814 0.50 35.55  ? 754  LEU A C   1 
ATOM   3552 O  O   . LEU A 1 491 ? -25.573 -51.814 -12.811 0.50 37.58  ? 754  LEU A O   1 
ATOM   3553 C  CB  . LEU A 1 491 ? -26.810 -50.093 -10.221 0.50 38.69  ? 754  LEU A CB  1 
ATOM   3554 C  CG  . LEU A 1 491 ? -25.452 -49.422 -10.416 0.50 40.45  ? 754  LEU A CG  1 
ATOM   3555 C  CD1 . LEU A 1 491 ? -25.471 -48.497 -11.625 0.50 40.19  ? 754  LEU A CD1 1 
ATOM   3556 C  CD2 . LEU A 1 491 ? -25.022 -48.666 -9.166  0.50 41.37  ? 754  LEU A CD2 1 
ATOM   3557 N  N   . GLY A 1 492 ? -26.256 -53.121 -11.071 1.00 31.76  ? 755  GLY A N   1 
ATOM   3558 C  CA  . GLY A 1 492 ? -25.431 -54.279 -11.432 1.00 29.06  ? 755  GLY A CA  1 
ATOM   3559 C  C   . GLY A 1 492 ? -25.709 -54.770 -12.860 1.00 30.67  ? 755  GLY A C   1 
ATOM   3560 O  O   . GLY A 1 492 ? -24.772 -55.077 -13.627 1.00 28.73  ? 755  GLY A O   1 
ATOM   3561 N  N   . LYS A 1 493 ? -26.972 -54.833 -13.237 1.00 27.51  ? 756  LYS A N   1 
ATOM   3562 C  CA  . LYS A 1 493 ? -27.431 -55.221 -14.595 1.00 31.47  ? 756  LYS A CA  1 
ATOM   3563 C  C   . LYS A 1 493 ? -26.957 -54.210 -15.649 1.00 28.72  ? 756  LYS A C   1 
ATOM   3564 O  O   . LYS A 1 493 ? -26.679 -54.646 -16.774 1.00 32.67  ? 756  LYS A O   1 
ATOM   3565 C  CB  . LYS A 1 493 ? -28.968 -55.302 -14.619 1.00 33.99  ? 756  LYS A CB  1 
ATOM   3566 C  CG  . LYS A 1 493 ? -29.560 -55.919 -15.879 1.00 33.55  ? 756  LYS A CG  1 
ATOM   3567 C  CD  . LYS A 1 493 ? -31.042 -56.103 -15.797 1.00 33.99  ? 756  LYS A CD  1 
ATOM   3568 C  CE  . LYS A 1 493 ? -31.625 -56.658 -17.077 1.00 37.90  ? 756  LYS A CE  1 
ATOM   3569 N  NZ  . LYS A 1 493 ? -32.939 -57.310 -16.832 1.00 41.19  ? 756  LYS A NZ  1 
ATOM   3570 N  N   . SER A 1 494 ? -26.931 -52.917 -15.338 1.00 25.59  ? 757  SER A N   1 
ATOM   3571 C  CA  . SER A 1 494 ? -26.388 -51.888 -16.257 1.00 31.82  ? 757  SER A CA  1 
ATOM   3572 C  C   . SER A 1 494 ? -24.932 -52.225 -16.548 1.00 29.60  ? 757  SER A C   1 
ATOM   3573 O  O   . SER A 1 494 ? -24.578 -52.124 -17.722 1.00 26.80  ? 757  SER A O   1 
ATOM   3574 C  CB  . SER A 1 494 ? -26.462 -50.474 -15.751 1.00 33.01  ? 757  SER A CB  1 
ATOM   3575 O  OG  . SER A 1 494 ? -27.791 -50.151 -15.403 1.00 42.86  ? 757  SER A OG  1 
ATOM   3576 N  N   . TYR A 1 495 ? -24.138 -52.575 -15.535 1.00 25.19  ? 758  TYR A N   1 
ATOM   3577 C  CA  . TYR A 1 495 ? -22.696 -52.907 -15.757 1.00 30.27  ? 758  TYR A CA  1 
ATOM   3578 C  C   . TYR A 1 495 ? -22.551 -54.184 -16.599 1.00 29.76  ? 758  TYR A C   1 
ATOM   3579 O  O   . TYR A 1 495 ? -21.731 -54.189 -17.538 1.00 30.47  ? 758  TYR A O   1 
ATOM   3580 C  CB  . TYR A 1 495 ? -21.930 -53.022 -14.444 1.00 28.22  ? 758  TYR A CB  1 
ATOM   3581 C  CG  . TYR A 1 495 ? -21.449 -51.690 -13.946 1.00 30.69  ? 758  TYR A CG  1 
ATOM   3582 C  CD1 . TYR A 1 495 ? -20.352 -51.066 -14.540 1.00 31.03  ? 758  TYR A CD1 1 
ATOM   3583 C  CD2 . TYR A 1 495 ? -22.089 -51.044 -12.901 1.00 30.05  ? 758  TYR A CD2 1 
ATOM   3584 C  CE1 . TYR A 1 495 ? -19.913 -49.830 -14.116 1.00 27.83  ? 758  TYR A CE1 1 
ATOM   3585 C  CE2 . TYR A 1 495 ? -21.654 -49.800 -12.459 1.00 31.19  ? 758  TYR A CE2 1 
ATOM   3586 C  CZ  . TYR A 1 495 ? -20.561 -49.200 -13.066 1.00 35.03  ? 758  TYR A CZ  1 
ATOM   3587 O  OH  . TYR A 1 495 ? -20.122 -47.995 -12.603 1.00 32.04  ? 758  TYR A OH  1 
ATOM   3588 N  N   . ALA A 1 496 ? -23.307 -55.227 -16.243 1.00 29.82  ? 759  ALA A N   1 
ATOM   3589 C  CA  . ALA A 1 496 ? -23.327 -56.530 -16.936 1.00 28.60  ? 759  ALA A CA  1 
ATOM   3590 C  C   . ALA A 1 496 ? -23.625 -56.304 -18.421 1.00 29.51  ? 759  ALA A C   1 
ATOM   3591 O  O   . ALA A 1 496 ? -22.917 -56.874 -19.253 1.00 29.46  ? 759  ALA A O   1 
ATOM   3592 C  CB  . ALA A 1 496 ? -24.350 -57.427 -16.299 1.00 29.42  ? 759  ALA A CB  1 
ATOM   3593 N  N   . GLN A 1 497 ? -24.645 -55.506 -18.749 1.00 30.24  ? 760  GLN A N   1 
ATOM   3594 C  CA  . GLN A 1 497 ? -25.052 -55.272 -20.172 1.00 32.55  ? 760  GLN A CA  1 
ATOM   3595 C  C   . GLN A 1 497 ? -23.971 -54.431 -20.878 1.00 27.58  ? 760  GLN A C   1 
ATOM   3596 O  O   . GLN A 1 497 ? -23.623 -54.753 -22.054 1.00 27.26  ? 760  GLN A O   1 
ATOM   3597 C  CB  . GLN A 1 497 ? -26.483 -54.708 -20.247 1.00 33.08  ? 760  GLN A CB  1 
ATOM   3598 C  CG  . GLN A 1 497 ? -27.498 -55.677 -19.654 1.00 34.02  ? 760  GLN A CG  1 
ATOM   3599 C  CD  . GLN A 1 497 ? -28.948 -55.446 -20.024 1.00 34.70  ? 760  GLN A CD  1 
ATOM   3600 O  OE1 . GLN A 1 497 ? -29.737 -56.394 -20.015 1.00 37.85  ? 760  GLN A OE1 1 
ATOM   3601 N  NE2 . GLN A 1 497 ? -29.299 -54.215 -20.358 1.00 29.50  ? 760  GLN A NE2 1 
ATOM   3602 N  N   . MET A 1 498 ? -23.328 -53.505 -20.166 1.00 25.15  ? 761  MET A N   1 
ATOM   3603 C  CA  . MET A 1 498 ? -22.211 -52.761 -20.786 1.00 27.29  ? 761  MET A CA  1 
ATOM   3604 C  C   . MET A 1 498 ? -21.096 -53.751 -21.138 1.00 25.31  ? 761  MET A C   1 
ATOM   3605 O  O   . MET A 1 498 ? -20.560 -53.681 -22.267 1.00 26.50  ? 761  MET A O   1 
ATOM   3606 C  CB  . MET A 1 498 ? -21.670 -51.656 -19.897 1.00 31.72  ? 761  MET A CB  1 
ATOM   3607 C  CG  . MET A 1 498 ? -20.424 -51.003 -20.516 1.00 35.85  ? 761  MET A CG  1 
ATOM   3608 S  SD  . MET A 1 498 ? -19.863 -49.694 -19.445 1.00 42.11  ? 761  MET A SD  1 
ATOM   3609 C  CE  . MET A 1 498 ? -19.142 -50.597 -18.084 1.00 38.28  ? 761  MET A CE  1 
ATOM   3610 N  N   . TRP A 1 499 ? -20.744 -54.640 -20.216 1.00 24.62  ? 762  TRP A N   1 
ATOM   3611 C  CA  . TRP A 1 499 ? -19.643 -55.619 -20.386 1.00 24.00  ? 762  TRP A CA  1 
ATOM   3612 C  C   . TRP A 1 499 ? -19.935 -56.534 -21.595 1.00 29.10  ? 762  TRP A C   1 
ATOM   3613 O  O   . TRP A 1 499 ? -18.998 -56.799 -22.370 1.00 31.25  ? 762  TRP A O   1 
ATOM   3614 C  CB  . TRP A 1 499 ? -19.443 -56.469 -19.126 1.00 25.19  ? 762  TRP A CB  1 
ATOM   3615 C  CG  . TRP A 1 499 ? -18.869 -55.774 -17.933 1.00 25.37  ? 762  TRP A CG  1 
ATOM   3616 C  CD1 . TRP A 1 499 ? -18.327 -54.534 -17.887 1.00 25.65  ? 762  TRP A CD1 1 
ATOM   3617 C  CD2 . TRP A 1 499 ? -18.705 -56.324 -16.615 1.00 25.09  ? 762  TRP A CD2 1 
ATOM   3618 N  NE1 . TRP A 1 499 ? -17.899 -54.256 -16.625 1.00 26.59  ? 762  TRP A NE1 1 
ATOM   3619 C  CE2 . TRP A 1 499 ? -18.087 -55.339 -15.832 1.00 23.35  ? 762  TRP A CE2 1 
ATOM   3620 C  CE3 . TRP A 1 499 ? -19.029 -57.541 -16.013 1.00 26.50  ? 762  TRP A CE3 1 
ATOM   3621 C  CZ2 . TRP A 1 499 ? -17.809 -55.516 -14.487 1.00 26.43  ? 762  TRP A CZ2 1 
ATOM   3622 C  CZ3 . TRP A 1 499 ? -18.794 -57.702 -14.665 1.00 25.54  ? 762  TRP A CZ3 1 
ATOM   3623 C  CH2 . TRP A 1 499 ? -18.160 -56.717 -13.921 1.00 25.76  ? 762  TRP A CH2 1 
ATOM   3624 N  N   A SER A 1 500 ? -21.176 -57.017 -21.733 0.25 27.86  ? 763  SER A N   1 
ATOM   3625 N  N   B SER A 1 500 ? -21.179 -57.019 -21.736 0.25 26.81  ? 763  SER A N   1 
ATOM   3626 C  CA  A SER A 1 500 ? -21.608 -57.896 -22.849 0.25 28.86  ? 763  SER A CA  1 
ATOM   3627 C  CA  B SER A 1 500 ? -21.603 -57.907 -22.851 0.25 27.15  ? 763  SER A CA  1 
ATOM   3628 C  C   A SER A 1 500 ? -21.473 -57.160 -24.182 0.25 27.72  ? 763  SER A C   1 
ATOM   3629 C  C   B SER A 1 500 ? -21.489 -57.164 -24.185 0.25 26.78  ? 763  SER A C   1 
ATOM   3630 O  O   A SER A 1 500 ? -21.153 -57.812 -25.181 0.25 29.09  ? 763  SER A O   1 
ATOM   3631 O  O   B SER A 1 500 ? -21.192 -57.816 -25.191 0.25 28.17  ? 763  SER A O   1 
ATOM   3632 C  CB  A SER A 1 500 ? -23.014 -58.381 -22.643 0.25 30.72  ? 763  SER A CB  1 
ATOM   3633 C  CB  B SER A 1 500 ? -23.002 -58.458 -22.654 0.25 27.72  ? 763  SER A CB  1 
ATOM   3634 O  OG  A SER A 1 500 ? -23.108 -59.080 -21.413 0.25 33.31  ? 763  SER A OG  1 
ATOM   3635 O  OG  B SER A 1 500 ? -23.980 -57.429 -22.655 0.25 27.50  ? 763  SER A OG  1 
ATOM   3636 N  N   . LEU A 1 501 ? -21.718 -55.853 -24.191 1.00 27.58  ? 764  LEU A N   1 
ATOM   3637 C  CA  . LEU A 1 501 ? -21.700 -55.052 -25.441 1.00 31.63  ? 764  LEU A CA  1 
ATOM   3638 C  C   . LEU A 1 501 ? -20.284 -54.598 -25.818 1.00 30.80  ? 764  LEU A C   1 
ATOM   3639 O  O   . LEU A 1 501 ? -19.933 -54.641 -27.011 1.00 31.00  ? 764  LEU A O   1 
ATOM   3640 C  CB  . LEU A 1 501 ? -22.645 -53.873 -25.249 1.00 36.17  ? 764  LEU A CB  1 
ATOM   3641 C  CG  . LEU A 1 501 ? -23.208 -53.349 -26.556 1.00 49.81  ? 764  LEU A CG  1 
ATOM   3642 C  CD1 . LEU A 1 501 ? -24.099 -54.403 -27.210 1.00 55.99  ? 764  LEU A CD1 1 
ATOM   3643 C  CD2 . LEU A 1 501 ? -23.973 -52.061 -26.298 1.00 59.34  ? 764  LEU A CD2 1 
ATOM   3644 N  N   . MET A 1 502 ? -19.500 -54.139 -24.857 1.00 29.48  ? 765  MET A N   1 
ATOM   3645 C  CA  . MET A 1 502 ? -18.210 -53.473 -25.145 1.00 30.30  ? 765  MET A CA  1 
ATOM   3646 C  C   . MET A 1 502 ? -17.041 -54.427 -24.852 1.00 30.23  ? 765  MET A C   1 
ATOM   3647 O  O   . MET A 1 502 ? -16.048 -54.327 -25.576 1.00 29.06  ? 765  MET A O   1 
ATOM   3648 C  CB  . MET A 1 502 ? -18.076 -52.211 -24.277 1.00 34.45  ? 765  MET A CB  1 
ATOM   3649 C  CG  . MET A 1 502 ? -19.169 -51.181 -24.488 1.00 33.60  ? 765  MET A CG  1 
ATOM   3650 S  SD  . MET A 1 502 ? -19.070 -50.394 -26.119 1.00 40.21  ? 765  MET A SD  1 
ATOM   3651 C  CE  . MET A 1 502 ? -20.008 -51.492 -27.166 1.00 52.40  ? 765  MET A CE  1 
ATOM   3652 N  N   . TYR A 1 503 ? -17.139 -55.246 -23.788 1.00 26.64  ? 766  TYR A N   1 
ATOM   3653 C  CA  . TYR A 1 503 ? -16.043 -56.063 -23.228 1.00 28.05  ? 766  TYR A CA  1 
ATOM   3654 C  C   . TYR A 1 503 ? -16.291 -57.584 -23.364 1.00 27.61  ? 766  TYR A C   1 
ATOM   3655 O  O   . TYR A 1 503 ? -15.724 -58.366 -22.585 1.00 27.73  ? 766  TYR A O   1 
ATOM   3656 C  CB  . TYR A 1 503 ? -15.844 -55.638 -21.770 1.00 31.21  ? 766  TYR A CB  1 
ATOM   3657 C  CG  . TYR A 1 503 ? -15.576 -54.161 -21.599 1.00 30.39  ? 766  TYR A CG  1 
ATOM   3658 C  CD1 . TYR A 1 503 ? -14.562 -53.512 -22.289 1.00 31.54  ? 766  TYR A CD1 1 
ATOM   3659 C  CD2 . TYR A 1 503 ? -16.385 -53.385 -20.786 1.00 31.38  ? 766  TYR A CD2 1 
ATOM   3660 C  CE1 . TYR A 1 503 ? -14.344 -52.147 -22.143 1.00 29.16  ? 766  TYR A CE1 1 
ATOM   3661 C  CE2 . TYR A 1 503 ? -16.180 -52.025 -20.629 1.00 29.44  ? 766  TYR A CE2 1 
ATOM   3662 C  CZ  . TYR A 1 503 ? -15.155 -51.400 -21.306 1.00 29.80  ? 766  TYR A CZ  1 
ATOM   3663 O  OH  . TYR A 1 503 ? -14.987 -50.070 -21.106 1.00 28.63  ? 766  TYR A OH  1 
ATOM   3664 N  N   . PHE A 1 504 ? -17.101 -58.017 -24.334 1.00 29.46  ? 767  PHE A N   1 
ATOM   3665 C  CA  . PHE A 1 504 ? -17.524 -59.430 -24.541 1.00 29.14  ? 767  PHE A CA  1 
ATOM   3666 C  C   . PHE A 1 504 ? -16.300 -60.316 -24.781 1.00 30.93  ? 767  PHE A C   1 
ATOM   3667 O  O   . PHE A 1 504 ? -16.369 -61.527 -24.516 1.00 27.64  ? 767  PHE A O   1 
ATOM   3668 C  CB  . PHE A 1 504 ? -18.421 -59.560 -25.768 1.00 28.87  ? 767  PHE A CB  1 
ATOM   3669 C  CG  . PHE A 1 504 ? -17.940 -58.783 -26.973 1.00 26.34  ? 767  PHE A CG  1 
ATOM   3670 C  CD1 . PHE A 1 504 ? -17.061 -59.351 -27.869 1.00 26.09  ? 767  PHE A CD1 1 
ATOM   3671 C  CD2 . PHE A 1 504 ? -18.364 -57.496 -27.205 1.00 26.79  ? 767  PHE A CD2 1 
ATOM   3672 C  CE1 . PHE A 1 504 ? -16.605 -58.657 -28.977 1.00 24.32  ? 767  PHE A CE1 1 
ATOM   3673 C  CE2 . PHE A 1 504 ? -17.917 -56.804 -28.323 1.00 28.81  ? 767  PHE A CE2 1 
ATOM   3674 C  CZ  . PHE A 1 504 ? -17.044 -57.387 -29.209 1.00 26.27  ? 767  PHE A CZ  1 
ATOM   3675 N  N   . HIS A 1 505 ? -15.226 -59.703 -25.284 1.00 31.12  ? 768  HIS A N   1 
ATOM   3676 C  CA  . HIS A 1 505 ? -13.968 -60.386 -25.711 1.00 30.17  ? 768  HIS A CA  1 
ATOM   3677 C  C   . HIS A 1 505 ? -13.103 -60.751 -24.491 1.00 28.59  ? 768  HIS A C   1 
ATOM   3678 O  O   . HIS A 1 505 ? -12.134 -61.501 -24.658 1.00 28.13  ? 768  HIS A O   1 
ATOM   3679 C  CB  . HIS A 1 505 ? -13.235 -59.501 -26.722 1.00 27.93  ? 768  HIS A CB  1 
ATOM   3680 C  CG  . HIS A 1 505 ? -13.069 -58.108 -26.233 1.00 28.81  ? 768  HIS A CG  1 
ATOM   3681 N  ND1 . HIS A 1 505 ? -12.024 -57.736 -25.427 1.00 29.02  ? 768  HIS A ND1 1 
ATOM   3682 C  CD2 . HIS A 1 505 ? -13.864 -57.019 -26.370 1.00 30.69  ? 768  HIS A CD2 1 
ATOM   3683 C  CE1 . HIS A 1 505 ? -12.173 -56.482 -25.084 1.00 29.56  ? 768  HIS A CE1 1 
ATOM   3684 N  NE2 . HIS A 1 505 ? -13.307 -56.008 -25.657 1.00 29.15  ? 768  HIS A NE2 1 
ATOM   3685 N  N   . ARG A 1 506 ? -13.440 -60.249 -23.303 1.00 26.68  ? 769  ARG A N   1 
ATOM   3686 C  CA  . ARG A 1 506 ? -12.761 -60.590 -22.025 1.00 26.49  ? 769  ARG A CA  1 
ATOM   3687 C  C   . ARG A 1 506 ? -13.531 -61.772 -21.423 1.00 27.58  ? 769  ARG A C   1 
ATOM   3688 O  O   . ARG A 1 506 ? -14.720 -61.619 -21.102 1.00 28.57  ? 769  ARG A O   1 
ATOM   3689 C  CB  . ARG A 1 506 ? -12.727 -59.380 -21.079 1.00 26.60  ? 769  ARG A CB  1 
ATOM   3690 C  CG  . ARG A 1 506 ? -12.171 -58.089 -21.672 1.00 26.16  ? 769  ARG A CG  1 
ATOM   3691 C  CD  . ARG A 1 506 ? -10.797 -58.202 -22.357 1.00 26.43  ? 769  ARG A CD  1 
ATOM   3692 N  NE  . ARG A 1 506 ? -9.896  -58.734 -21.378 1.00 25.87  ? 769  ARG A NE  1 
ATOM   3693 C  CZ  . ARG A 1 506 ? -9.372  -58.049 -20.373 1.00 25.32  ? 769  ARG A CZ  1 
ATOM   3694 N  NH1 . ARG A 1 506 ? -8.651  -58.683 -19.463 1.00 26.11  ? 769  ARG A NH1 1 
ATOM   3695 N  NH2 . ARG A 1 506 ? -9.523  -56.746 -20.280 1.00 25.04  ? 769  ARG A NH2 1 
ATOM   3696 N  N   . ARG A 1 507 ? -12.866 -62.926 -21.290 0.50 27.88  ? 770  ARG A N   1 
ATOM   3697 C  CA  . ARG A 1 507 ? -13.462 -64.190 -20.780 0.50 27.52  ? 770  ARG A CA  1 
ATOM   3698 C  C   . ARG A 1 507 ? -14.185 -63.937 -19.452 0.50 27.31  ? 770  ARG A C   1 
ATOM   3699 O  O   . ARG A 1 507 ? -15.350 -64.352 -19.335 0.50 27.44  ? 770  ARG A O   1 
ATOM   3700 C  CB  . ARG A 1 507 ? -12.386 -65.264 -20.601 0.50 28.64  ? 770  ARG A CB  1 
ATOM   3701 C  CG  . ARG A 1 507 ? -11.893 -65.865 -21.909 0.50 29.46  ? 770  ARG A CG  1 
ATOM   3702 C  CD  . ARG A 1 507 ? -10.576 -66.604 -21.784 0.50 28.74  ? 770  ARG A CD  1 
ATOM   3703 N  NE  . ARG A 1 507 ? -10.205 -67.140 -23.081 0.50 28.75  ? 770  ARG A NE  1 
ATOM   3704 C  CZ  . ARG A 1 507 ? -9.670  -66.417 -24.057 0.50 29.75  ? 770  ARG A CZ  1 
ATOM   3705 N  NH1 . ARG A 1 507 ? -9.427  -65.132 -23.862 0.50 28.56  ? 770  ARG A NH1 1 
ATOM   3706 N  NH2 . ARG A 1 507 ? -9.375  -66.978 -25.217 0.50 29.65  ? 770  ARG A NH2 1 
ATOM   3707 N  N   . ASP A 1 508 ? -13.526 -63.284 -18.492 1.00 26.73  ? 771  ASP A N   1 
ATOM   3708 C  CA  . ASP A 1 508 ? -14.087 -63.147 -17.114 1.00 27.39  ? 771  ASP A CA  1 
ATOM   3709 C  C   . ASP A 1 508 ? -15.349 -62.271 -17.148 1.00 27.77  ? 771  ASP A C   1 
ATOM   3710 O  O   . ASP A 1 508 ? -16.262 -62.474 -16.297 1.00 28.01  ? 771  ASP A O   1 
ATOM   3711 C  CB  . ASP A 1 508 ? -13.070 -62.579 -16.128 1.00 26.25  ? 771  ASP A CB  1 
ATOM   3712 C  CG  . ASP A 1 508 ? -11.834 -63.437 -15.962 1.00 26.19  ? 771  ASP A CG  1 
ATOM   3713 O  OD1 . ASP A 1 508 ? -11.880 -64.596 -16.360 1.00 24.57  ? 771  ASP A OD1 1 
ATOM   3714 O  OD2 . ASP A 1 508 ? -10.847 -62.916 -15.420 1.00 27.31  ? 771  ASP A OD2 1 
ATOM   3715 N  N   . LEU A 1 509 ? -15.388 -61.295 -18.056 1.00 27.58  ? 772  LEU A N   1 
ATOM   3716 C  CA  . LEU A 1 509 ? -16.460 -60.269 -18.050 1.00 26.83  ? 772  LEU A CA  1 
ATOM   3717 C  C   . LEU A 1 509 ? -17.683 -60.858 -18.746 1.00 26.97  ? 772  LEU A C   1 
ATOM   3718 O  O   . LEU A 1 509 ? -18.781 -60.554 -18.304 1.00 26.27  ? 772  LEU A O   1 
ATOM   3719 C  CB  . LEU A 1 509 ? -15.953 -58.958 -18.683 1.00 27.19  ? 772  LEU A CB  1 
ATOM   3720 C  CG  . LEU A 1 509 ? -14.859 -58.198 -17.903 1.00 25.62  ? 772  LEU A CG  1 
ATOM   3721 C  CD1 . LEU A 1 509 ? -14.712 -56.774 -18.391 1.00 24.16  ? 772  LEU A CD1 1 
ATOM   3722 C  CD2 . LEU A 1 509 ? -15.091 -58.215 -16.392 1.00 24.90  ? 772  LEU A CD2 1 
ATOM   3723 N  N   . ARG A 1 510 ? -17.506 -61.680 -19.792 1.00 30.21  ? 773  ARG A N   1 
ATOM   3724 C  CA  . ARG A 1 510 ? -18.650 -62.291 -20.496 1.00 26.66  ? 773  ARG A CA  1 
ATOM   3725 C  C   . ARG A 1 510 ? -19.297 -63.253 -19.506 1.00 29.45  ? 773  ARG A C   1 
ATOM   3726 O  O   . ARG A 1 510 ? -20.543 -63.301 -19.447 1.00 28.78  ? 773  ARG A O   1 
ATOM   3727 C  CB  . ARG A 1 510 ? -18.255 -63.020 -21.780 1.00 28.05  ? 773  ARG A CB  1 
ATOM   3728 C  CG  . ARG A 1 510 ? -19.444 -63.302 -22.699 1.00 29.06  ? 773  ARG A CG  1 
ATOM   3729 C  CD  . ARG A 1 510 ? -19.197 -64.228 -23.868 1.00 27.86  ? 773  ARG A CD  1 
ATOM   3730 N  NE  . ARG A 1 510 ? -18.300 -63.634 -24.836 1.00 29.48  ? 773  ARG A NE  1 
ATOM   3731 C  CZ  . ARG A 1 510 ? -18.148 -64.043 -26.115 1.00 32.73  ? 773  ARG A CZ  1 
ATOM   3732 N  NH1 . ARG A 1 510 ? -18.888 -65.026 -26.599 1.00 32.26  ? 773  ARG A NH1 1 
ATOM   3733 N  NH2 . ARG A 1 510 ? -17.283 -63.440 -26.923 1.00 28.00  ? 773  ARG A NH2 1 
ATOM   3734 N  N   . LEU A 1 511 ? -18.481 -63.980 -18.743 1.00 28.47  ? 774  LEU A N   1 
ATOM   3735 C  CA  . LEU A 1 511 ? -18.998 -64.960 -17.753 1.00 28.26  ? 774  LEU A CA  1 
ATOM   3736 C  C   . LEU A 1 511 ? -19.686 -64.190 -16.627 1.00 25.80  ? 774  LEU A C   1 
ATOM   3737 O  O   . LEU A 1 511 ? -20.805 -64.516 -16.319 1.00 29.30  ? 774  LEU A O   1 
ATOM   3738 C  CB  . LEU A 1 511 ? -17.853 -65.845 -17.258 1.00 30.14  ? 774  LEU A CB  1 
ATOM   3739 C  CG  . LEU A 1 511 ? -18.254 -67.151 -16.566 1.00 31.47  ? 774  LEU A CG  1 
ATOM   3740 C  CD1 . LEU A 1 511 ? -17.057 -68.053 -16.428 1.00 35.39  ? 774  LEU A CD1 1 
ATOM   3741 C  CD2 . LEU A 1 511 ? -18.829 -66.906 -15.186 1.00 34.61  ? 774  LEU A CD2 1 
ATOM   3742 N  N   . ALA A 1 512 ? -19.081 -63.157 -16.078 1.00 25.34  ? 775  ALA A N   1 
ATOM   3743 C  CA  . ALA A 1 512 ? -19.658 -62.429 -14.927 1.00 25.34  ? 775  ALA A CA  1 
ATOM   3744 C  C   . ALA A 1 512 ? -20.929 -61.689 -15.387 1.00 27.21  ? 775  ALA A C   1 
ATOM   3745 O  O   . ALA A 1 512 ? -21.910 -61.673 -14.638 1.00 27.85  ? 775  ALA A O   1 
ATOM   3746 C  CB  . ALA A 1 512 ? -18.625 -61.513 -14.324 1.00 23.50  ? 775  ALA A CB  1 
ATOM   3747 N  N   . ALA A 1 513 ? -20.950 -61.201 -16.624 1.00 26.12  ? 776  ALA A N   1 
ATOM   3748 C  CA  . ALA A 1 513 ? -22.084 -60.449 -17.191 1.00 26.95  ? 776  ALA A CA  1 
ATOM   3749 C  C   . ALA A 1 513 ? -23.276 -61.395 -17.244 1.00 30.20  ? 776  ALA A C   1 
ATOM   3750 O  O   . ALA A 1 513 ? -24.395 -60.962 -16.823 1.00 30.36  ? 776  ALA A O   1 
ATOM   3751 C  CB  . ALA A 1 513 ? -21.748 -59.837 -18.554 1.00 23.38  ? 776  ALA A CB  1 
ATOM   3752 N  N   . ASN A 1 514 ? -23.059 -62.594 -17.793 1.00 31.61  ? 777  ASN A N   1 
ATOM   3753 C  CA  . ASN A 1 514 ? -24.106 -63.639 -17.920 1.00 32.30  ? 777  ASN A CA  1 
ATOM   3754 C  C   . ASN A 1 514 ? -24.593 -64.043 -16.530 1.00 30.88  ? 777  ASN A C   1 
ATOM   3755 O  O   . ASN A 1 514 ? -25.809 -64.239 -16.358 1.00 31.86  ? 777  ASN A O   1 
ATOM   3756 C  CB  . ASN A 1 514 ? -23.619 -64.864 -18.684 1.00 32.12  ? 777  ASN A CB  1 
ATOM   3757 C  CG  . ASN A 1 514 ? -23.515 -64.595 -20.169 1.00 32.83  ? 777  ASN A CG  1 
ATOM   3758 O  OD1 . ASN A 1 514 ? -24.377 -63.975 -20.753 1.00 31.17  ? 777  ASN A OD1 1 
ATOM   3759 N  ND2 . ASN A 1 514 ? -22.470 -65.074 -20.805 1.00 35.56  ? 777  ASN A ND2 1 
ATOM   3760 N  N   . ALA A 1 515 ? -23.695 -64.187 -15.568 1.00 28.35  ? 778  ALA A N   1 
ATOM   3761 C  CA  . ALA A 1 515 ? -24.075 -64.544 -14.184 1.00 26.20  ? 778  ALA A CA  1 
ATOM   3762 C  C   . ALA A 1 515 ? -24.970 -63.429 -13.617 1.00 28.77  ? 778  ALA A C   1 
ATOM   3763 O  O   . ALA A 1 515 ? -25.992 -63.735 -13.032 1.00 31.11  ? 778  ALA A O   1 
ATOM   3764 C  CB  . ALA A 1 515 ? -22.866 -64.789 -13.323 1.00 24.28  ? 778  ALA A CB  1 
ATOM   3765 N  N   . ILE A 1 516 ? -24.600 -62.163 -13.763 1.00 30.44  ? 779  ILE A N   1 
ATOM   3766 C  CA  . ILE A 1 516 ? -25.381 -61.065 -13.132 1.00 31.93  ? 779  ILE A CA  1 
ATOM   3767 C  C   . ILE A 1 516 ? -26.769 -61.003 -13.788 1.00 34.02  ? 779  ILE A C   1 
ATOM   3768 O  O   . ILE A 1 516 ? -27.743 -60.954 -13.020 1.00 34.87  ? 779  ILE A O   1 
ATOM   3769 C  CB  . ILE A 1 516 ? -24.641 -59.722 -13.192 1.00 28.37  ? 779  ILE A CB  1 
ATOM   3770 C  CG1 . ILE A 1 516 ? -23.373 -59.761 -12.353 1.00 29.57  ? 779  ILE A CG1 1 
ATOM   3771 C  CG2 . ILE A 1 516 ? -25.546 -58.580 -12.761 1.00 27.66  ? 779  ILE A CG2 1 
ATOM   3772 C  CD1 . ILE A 1 516 ? -22.378 -58.720 -12.779 1.00 30.76  ? 779  ILE A CD1 1 
ATOM   3773 N  N   . CYS A 1 517 ? -26.855 -61.039 -15.126 1.00 30.22  ? 780  CYS A N   1 
ATOM   3774 C  CA  . CYS A 1 517 ? -28.130 -60.992 -15.882 1.00 31.89  ? 780  CYS A CA  1 
ATOM   3775 C  C   . CYS A 1 517 ? -28.976 -62.230 -15.570 1.00 31.95  ? 780  CYS A C   1 
ATOM   3776 O  O   . CYS A 1 517 ? -30.191 -62.171 -15.759 1.00 31.67  ? 780  CYS A O   1 
ATOM   3777 C  CB  . CYS A 1 517 ? -27.895 -60.876 -17.380 1.00 31.60  ? 780  CYS A CB  1 
ATOM   3778 S  SG  . CYS A 1 517 ? -27.162 -59.283 -17.812 1.00 35.57  ? 780  CYS A SG  1 
ATOM   3779 N  N   . SER A 1 518 ? -28.361 -63.311 -15.111 1.00 31.81  ? 781  SER A N   1 
ATOM   3780 C  CA  . SER A 1 518 ? -29.080 -64.530 -14.666 1.00 32.59  ? 781  SER A CA  1 
ATOM   3781 C  C   . SER A 1 518 ? -29.602 -64.324 -13.236 1.00 32.29  ? 781  SER A C   1 
ATOM   3782 O  O   . SER A 1 518 ? -30.654 -64.898 -12.912 1.00 31.42  ? 781  SER A O   1 
ATOM   3783 C  CB  . SER A 1 518 ? -28.208 -65.772 -14.771 1.00 34.17  ? 781  SER A CB  1 
ATOM   3784 O  OG  . SER A 1 518 ? -27.937 -66.101 -16.124 1.00 36.44  ? 781  SER A OG  1 
ATOM   3785 N  N   . ALA A 1 519 ? -28.923 -63.507 -12.426 1.00 32.07  ? 782  ALA A N   1 
ATOM   3786 C  CA  . ALA A 1 519 ? -29.165 -63.372 -10.963 1.00 35.21  ? 782  ALA A CA  1 
ATOM   3787 C  C   . ALA A 1 519 ? -30.204 -62.289 -10.684 1.00 31.46  ? 782  ALA A C   1 
ATOM   3788 O  O   . ALA A 1 519 ? -30.664 -62.251 -9.578  1.00 33.66  ? 782  ALA A O   1 
ATOM   3789 C  CB  . ALA A 1 519 ? -27.889 -63.063 -10.207 1.00 33.91  ? 782  ALA A CB  1 
ATOM   3790 N  N   . VAL A 1 520 ? -30.433 -61.410 -11.652 1.00 31.33  ? 783  VAL A N   1 
ATOM   3791 C  CA  . VAL A 1 520 ? -31.354 -60.257 -11.596 1.00 32.25  ? 783  VAL A CA  1 
ATOM   3792 C  C   . VAL A 1 520 ? -32.596 -60.598 -12.428 1.00 34.68  ? 783  VAL A C   1 
ATOM   3793 O  O   . VAL A 1 520 ? -32.495 -61.123 -13.546 1.00 32.44  ? 783  VAL A O   1 
ATOM   3794 C  CB  . VAL A 1 520 ? -30.664 -58.976 -12.098 1.00 33.25  ? 783  VAL A CB  1 
ATOM   3795 C  CG1 . VAL A 1 520 ? -31.592 -57.765 -12.037 1.00 33.88  ? 783  VAL A CG1 1 
ATOM   3796 C  CG2 . VAL A 1 520 ? -29.373 -58.675 -11.345 1.00 32.88  ? 783  VAL A CG2 1 
ATOM   3797 N  N   . PRO A 1 521 ? -33.813 -60.306 -11.910 1.00 32.31  ? 784  PRO A N   1 
ATOM   3798 C  CA  . PRO A 1 521 ? -35.040 -60.658 -12.618 1.00 33.23  ? 784  PRO A CA  1 
ATOM   3799 C  C   . PRO A 1 521 ? -34.968 -60.153 -14.065 1.00 32.49  ? 784  PRO A C   1 
ATOM   3800 O  O   . PRO A 1 521 ? -34.560 -59.028 -14.297 1.00 33.24  ? 784  PRO A O   1 
ATOM   3801 C  CB  . PRO A 1 521 ? -36.119 -60.021 -11.731 1.00 34.20  ? 784  PRO A CB  1 
ATOM   3802 C  CG  . PRO A 1 521 ? -35.537 -60.141 -10.349 1.00 36.26  ? 784  PRO A CG  1 
ATOM   3803 C  CD  . PRO A 1 521 ? -34.071 -59.788 -10.565 1.00 34.02  ? 784  PRO A CD  1 
ATOM   3804 N  N   A SER A 1 522 ? -35.366 -61.009 -15.010 0.25 33.16  ? 785  SER A N   1 
ATOM   3805 N  N   B SER A 1 522 ? -35.390 -61.011 -14.995 0.25 32.21  ? 785  SER A N   1 
ATOM   3806 C  CA  A SER A 1 522 ? -35.223 -60.817 -16.478 0.25 35.18  ? 785  SER A CA  1 
ATOM   3807 C  CA  B SER A 1 522 ? -35.271 -60.862 -16.469 0.25 33.57  ? 785  SER A CA  1 
ATOM   3808 C  C   A SER A 1 522 ? -35.813 -59.476 -16.924 0.25 36.21  ? 785  SER A C   1 
ATOM   3809 C  C   B SER A 1 522 ? -35.839 -59.520 -16.945 0.25 35.18  ? 785  SER A C   1 
ATOM   3810 O  O   A SER A 1 522 ? -35.181 -58.810 -17.765 0.25 38.05  ? 785  SER A O   1 
ATOM   3811 O  O   B SER A 1 522 ? -35.213 -58.897 -17.822 0.25 36.99  ? 785  SER A O   1 
ATOM   3812 C  CB  A SER A 1 522 ? -35.866 -61.949 -17.229 0.25 37.17  ? 785  SER A CB  1 
ATOM   3813 C  CB  B SER A 1 522 ? -35.960 -62.015 -17.147 0.25 34.42  ? 785  SER A CB  1 
ATOM   3814 O  OG  A SER A 1 522 ? -37.270 -61.760 -17.307 0.25 39.41  ? 785  SER A OG  1 
ATOM   3815 O  OG  B SER A 1 522 ? -35.928 -63.172 -16.318 0.25 33.85  ? 785  SER A OG  1 
ATOM   3816 N  N   . HIS A 1 523 ? -36.980 -59.101 -16.387 1.00 37.79  ? 786  HIS A N   1 
ATOM   3817 C  CA  . HIS A 1 523 ? -37.721 -57.875 -16.799 1.00 37.15  ? 786  HIS A CA  1 
ATOM   3818 C  C   . HIS A 1 523 ? -37.312 -56.614 -16.027 1.00 35.71  ? 786  HIS A C   1 
ATOM   3819 O  O   . HIS A 1 523 ? -37.790 -55.524 -16.451 1.00 38.46  ? 786  HIS A O   1 
ATOM   3820 C  CB  . HIS A 1 523 ? -39.239 -58.146 -16.710 1.00 41.10  ? 786  HIS A CB  1 
ATOM   3821 C  CG  . HIS A 1 523 ? -39.643 -59.236 -17.640 1.00 42.34  ? 786  HIS A CG  1 
ATOM   3822 N  ND1 . HIS A 1 523 ? -39.677 -59.052 -19.020 1.00 43.56  ? 786  HIS A ND1 1 
ATOM   3823 C  CD2 . HIS A 1 523 ? -39.934 -60.535 -17.413 1.00 49.02  ? 786  HIS A CD2 1 
ATOM   3824 C  CE1 . HIS A 1 523 ? -40.002 -60.181 -19.602 1.00 45.62  ? 786  HIS A CE1 1 
ATOM   3825 N  NE2 . HIS A 1 523 ? -40.170 -61.117 -18.631 1.00 50.83  ? 786  HIS A NE2 1 
ATOM   3826 N  N   . TRP A 1 524 ? -36.470 -56.683 -14.985 1.00 34.25  ? 787  TRP A N   1 
ATOM   3827 C  CA  . TRP A 1 524 ? -36.047 -55.452 -14.243 1.00 34.70  ? 787  TRP A CA  1 
ATOM   3828 C  C   . TRP A 1 524 ? -35.171 -54.585 -15.137 1.00 36.10  ? 787  TRP A C   1 
ATOM   3829 O  O   . TRP A 1 524 ? -34.342 -55.125 -15.917 1.00 34.69  ? 787  TRP A O   1 
ATOM   3830 C  CB  . TRP A 1 524 ? -35.362 -55.775 -12.921 1.00 36.48  ? 787  TRP A CB  1 
ATOM   3831 C  CG  . TRP A 1 524 ? -36.344 -56.242 -11.892 1.00 38.71  ? 787  TRP A CG  1 
ATOM   3832 C  CD1 . TRP A 1 524 ? -37.665 -56.533 -12.095 1.00 37.69  ? 787  TRP A CD1 1 
ATOM   3833 C  CD2 . TRP A 1 524 ? -36.093 -56.504 -10.504 1.00 38.52  ? 787  TRP A CD2 1 
ATOM   3834 N  NE1 . TRP A 1 524 ? -38.244 -56.966 -10.937 1.00 34.76  ? 787  TRP A NE1 1 
ATOM   3835 C  CE2 . TRP A 1 524 ? -37.316 -56.925 -9.934  1.00 36.76  ? 787  TRP A CE2 1 
ATOM   3836 C  CE3 . TRP A 1 524 ? -34.965 -56.417 -9.685  1.00 41.00  ? 787  TRP A CE3 1 
ATOM   3837 C  CZ2 . TRP A 1 524 ? -37.434 -57.269 -8.590  1.00 36.25  ? 787  TRP A CZ2 1 
ATOM   3838 C  CZ3 . TRP A 1 524 ? -35.084 -56.771 -8.357  1.00 40.29  ? 787  TRP A CZ3 1 
ATOM   3839 C  CH2 . TRP A 1 524 ? -36.298 -57.198 -7.823  1.00 34.99  ? 787  TRP A CH2 1 
ATOM   3840 N  N   . VAL A 1 525 ? -35.399 -53.283 -15.072 1.00 35.72  ? 788  VAL A N   1 
ATOM   3841 C  CA  . VAL A 1 525 ? -34.819 -52.332 -16.048 1.00 36.97  ? 788  VAL A CA  1 
ATOM   3842 C  C   . VAL A 1 525 ? -33.477 -51.858 -15.491 1.00 37.27  ? 788  VAL A C   1 
ATOM   3843 O  O   . VAL A 1 525 ? -33.396 -51.361 -14.372 1.00 35.43  ? 788  VAL A O   1 
ATOM   3844 C  CB  . VAL A 1 525 ? -35.813 -51.183 -16.308 1.00 38.67  ? 788  VAL A CB  1 
ATOM   3845 C  CG1 . VAL A 1 525 ? -35.241 -50.112 -17.233 1.00 41.07  ? 788  VAL A CG1 1 
ATOM   3846 C  CG2 . VAL A 1 525 ? -37.147 -51.695 -16.836 1.00 38.36  ? 788  VAL A CG2 1 
ATOM   3847 N  N   . PRO A 1 526 ? -32.409 -51.903 -16.318 1.00 42.19  ? 789  PRO A N   1 
ATOM   3848 C  CA  . PRO A 1 526 ? -31.112 -51.356 -15.916 1.00 42.64  ? 789  PRO A CA  1 
ATOM   3849 C  C   . PRO A 1 526 ? -31.187 -49.873 -15.524 1.00 47.03  ? 789  PRO A C   1 
ATOM   3850 O  O   . PRO A 1 526 ? -31.926 -49.151 -16.138 1.00 44.52  ? 789  PRO A O   1 
ATOM   3851 C  CB  . PRO A 1 526 ? -30.288 -51.510 -17.195 1.00 40.12  ? 789  PRO A CB  1 
ATOM   3852 C  CG  . PRO A 1 526 ? -30.897 -52.682 -17.903 1.00 39.79  ? 789  PRO A CG  1 
ATOM   3853 C  CD  . PRO A 1 526 ? -32.375 -52.507 -17.655 1.00 41.80  ? 789  PRO A CD  1 
ATOM   3854 N  N   . THR A 1 527 ? -30.418 -49.466 -14.512 0.50 52.51  ? 790  THR A N   1 
ATOM   3855 C  CA  . THR A 1 527 ? -30.462 -48.066 -14.023 0.50 59.13  ? 790  THR A CA  1 
ATOM   3856 C  C   . THR A 1 527 ? -29.050 -47.538 -13.784 0.50 61.57  ? 790  THR A C   1 
ATOM   3857 O  O   . THR A 1 527 ? -28.126 -48.359 -13.682 0.50 62.17  ? 790  THR A O   1 
ATOM   3858 C  CB  . THR A 1 527 ? -31.231 -47.961 -12.702 0.50 63.34  ? 790  THR A CB  1 
ATOM   3859 O  OG1 . THR A 1 527 ? -30.516 -48.704 -11.714 0.50 64.60  ? 790  THR A OG1 1 
ATOM   3860 C  CG2 . THR A 1 527 ? -32.649 -48.471 -12.809 0.50 65.62  ? 790  THR A CG2 1 
ATOM   3861 N  N   . SER A 1 528 ? -28.902 -46.216 -13.685 1.00 64.70  ? 791  SER A N   1 
ATOM   3862 C  CA  . SER A 1 528 ? -27.580 -45.604 -13.381 1.00 69.80  ? 791  SER A CA  1 
ATOM   3863 C  C   . SER A 1 528 ? -27.765 -44.448 -12.397 1.00 79.80  ? 791  SER A C   1 
ATOM   3864 O  O   . SER A 1 528 ? -28.895 -43.945 -12.326 1.00 91.77  ? 791  SER A O   1 
ATOM   3865 C  CB  . SER A 1 528 ? -26.880 -45.140 -14.616 1.00 66.06  ? 791  SER A CB  1 
ATOM   3866 O  OG  . SER A 1 528 ? -25.525 -44.838 -14.330 1.00 78.52  ? 791  SER A OG  1 
ATOM   3867 N  N   . ALA A 1 536 ? -20.956 -40.970 -24.131 1.00 109.28 ? 799  ALA A N   1 
ATOM   3868 C  CA  . ALA A 1 536 ? -21.443 -40.742 -25.514 1.00 104.49 ? 799  ALA A CA  1 
ATOM   3869 C  C   . ALA A 1 536 ? -22.743 -41.540 -25.750 1.00 102.50 ? 799  ALA A C   1 
ATOM   3870 O  O   . ALA A 1 536 ? -23.833 -40.973 -25.484 1.00 101.22 ? 799  ALA A O   1 
ATOM   3871 C  CB  . ALA A 1 536 ? -20.348 -41.072 -26.510 1.00 99.27  ? 799  ALA A CB  1 
ATOM   3872 N  N   . THR A 1 537 ? -22.656 -42.803 -26.196 1.00 83.17  ? 800  THR A N   1 
ATOM   3873 C  CA  . THR A 1 537 ? -23.835 -43.636 -26.563 1.00 74.66  ? 800  THR A CA  1 
ATOM   3874 C  C   . THR A 1 537 ? -23.927 -44.855 -25.624 1.00 70.21  ? 800  THR A C   1 
ATOM   3875 O  O   . THR A 1 537 ? -22.940 -45.669 -25.547 1.00 65.14  ? 800  THR A O   1 
ATOM   3876 C  CB  . THR A 1 537 ? -23.811 -44.013 -28.049 1.00 76.76  ? 800  THR A CB  1 
ATOM   3877 O  OG1 . THR A 1 537 ? -23.028 -45.191 -28.200 1.00 85.95  ? 800  THR A OG1 1 
ATOM   3878 C  CG2 . THR A 1 537 ? -23.272 -42.914 -28.936 1.00 77.35  ? 800  THR A CG2 1 
ATOM   3879 N  N   . HIS A 1 538 ? -25.066 -44.987 -24.930 0.30 64.07  ? 801  HIS A N   1 
ATOM   3880 C  CA  . HIS A 1 538 ? -25.329 -46.008 -23.878 0.30 58.22  ? 801  HIS A CA  1 
ATOM   3881 C  C   . HIS A 1 538 ? -26.371 -47.018 -24.375 0.30 51.86  ? 801  HIS A C   1 
ATOM   3882 O  O   . HIS A 1 538 ? -27.483 -47.040 -23.810 0.30 50.38  ? 801  HIS A O   1 
ATOM   3883 C  CB  . HIS A 1 538 ? -25.775 -45.320 -22.583 0.30 60.08  ? 801  HIS A CB  1 
ATOM   3884 C  CG  . HIS A 1 538 ? -24.672 -44.627 -21.855 0.30 61.81  ? 801  HIS A CG  1 
ATOM   3885 N  ND1 . HIS A 1 538 ? -24.601 -44.604 -20.473 0.30 62.19  ? 801  HIS A ND1 1 
ATOM   3886 C  CD2 . HIS A 1 538 ? -23.595 -43.945 -22.302 0.30 62.37  ? 801  HIS A CD2 1 
ATOM   3887 C  CE1 . HIS A 1 538 ? -23.532 -43.930 -20.102 0.30 62.63  ? 801  HIS A CE1 1 
ATOM   3888 N  NE2 . HIS A 1 538 ? -22.896 -43.516 -21.206 0.30 62.79  ? 801  HIS A NE2 1 
ATOM   3889 N  N   . GLU A 1 539 ? -26.007 -47.833 -25.371 1.00 45.57  ? 802  GLU A N   1 
ATOM   3890 C  CA  . GLU A 1 539 ? -26.926 -48.837 -25.984 1.00 48.17  ? 802  GLU A CA  1 
ATOM   3891 C  C   . GLU A 1 539 ? -27.274 -49.995 -25.047 1.00 46.68  ? 802  GLU A C   1 
ATOM   3892 O  O   . GLU A 1 539 ? -28.219 -50.760 -25.386 1.00 45.20  ? 802  GLU A O   1 
ATOM   3893 C  CB  . GLU A 1 539 ? -26.351 -49.496 -27.230 1.00 52.69  ? 802  GLU A CB  1 
ATOM   3894 C  CG  . GLU A 1 539 ? -26.696 -48.754 -28.500 1.00 57.70  ? 802  GLU A CG  1 
ATOM   3895 C  CD  . GLU A 1 539 ? -25.684 -47.664 -28.742 1.00 62.59  ? 802  GLU A CD  1 
ATOM   3896 O  OE1 . GLU A 1 539 ? -25.823 -46.980 -29.774 1.00 71.95  ? 802  GLU A OE1 1 
ATOM   3897 O  OE2 . GLU A 1 539 ? -24.748 -47.530 -27.884 1.00 64.52  ? 802  GLU A OE2 1 
ATOM   3898 N  N   . TRP A 1 540 ? -26.514 -50.178 -23.970 1.00 39.17  ? 803  TRP A N   1 
ATOM   3899 C  CA  . TRP A 1 540 ? -26.761 -51.274 -23.002 1.00 39.39  ? 803  TRP A CA  1 
ATOM   3900 C  C   . TRP A 1 540 ? -27.899 -50.896 -22.045 1.00 40.48  ? 803  TRP A C   1 
ATOM   3901 O  O   . TRP A 1 540 ? -28.238 -51.716 -21.204 1.00 41.14  ? 803  TRP A O   1 
ATOM   3902 C  CB  . TRP A 1 540 ? -25.451 -51.598 -22.268 1.00 37.17  ? 803  TRP A CB  1 
ATOM   3903 C  CG  . TRP A 1 540 ? -24.826 -50.472 -21.504 1.00 32.39  ? 803  TRP A CG  1 
ATOM   3904 C  CD1 . TRP A 1 540 ? -25.106 -50.109 -20.216 1.00 31.24  ? 803  TRP A CD1 1 
ATOM   3905 C  CD2 . TRP A 1 540 ? -23.811 -49.555 -21.975 1.00 33.00  ? 803  TRP A CD2 1 
ATOM   3906 N  NE1 . TRP A 1 540 ? -24.349 -49.016 -19.855 1.00 33.41  ? 803  TRP A NE1 1 
ATOM   3907 C  CE2 . TRP A 1 540 ? -23.538 -48.659 -20.914 1.00 33.78  ? 803  TRP A CE2 1 
ATOM   3908 C  CE3 . TRP A 1 540 ? -23.095 -49.410 -23.174 1.00 35.37  ? 803  TRP A CE3 1 
ATOM   3909 C  CZ2 . TRP A 1 540 ? -22.541 -47.677 -21.011 1.00 35.31  ? 803  TRP A CZ2 1 
ATOM   3910 C  CZ3 . TRP A 1 540 ? -22.120 -48.443 -23.271 1.00 34.48  ? 803  TRP A CZ3 1 
ATOM   3911 C  CH2 . TRP A 1 540 ? -21.845 -47.585 -22.197 1.00 35.12  ? 803  TRP A CH2 1 
ATOM   3912 N  N   . MET A 1 541 ? -28.400 -49.655 -22.087 1.00 44.85  ? 804  MET A N   1 
ATOM   3913 C  CA  . MET A 1 541 ? -29.477 -49.195 -21.168 1.00 45.85  ? 804  MET A CA  1 
ATOM   3914 C  C   . MET A 1 541 ? -30.823 -49.496 -21.849 1.00 44.55  ? 804  MET A C   1 
ATOM   3915 O  O   . MET A 1 541 ? -31.340 -48.627 -22.563 1.00 43.82  ? 804  MET A O   1 
ATOM   3916 C  CB  . MET A 1 541 ? -29.354 -47.703 -20.826 1.00 45.01  ? 804  MET A CB  1 
ATOM   3917 C  CG  . MET A 1 541 ? -28.094 -47.321 -20.079 1.00 43.79  ? 804  MET A CG  1 
ATOM   3918 S  SD  . MET A 1 541 ? -27.925 -48.176 -18.490 1.00 50.89  ? 804  MET A SD  1 
ATOM   3919 C  CE  . MET A 1 541 ? -29.151 -47.317 -17.502 1.00 52.48  ? 804  MET A CE  1 
ATOM   3920 N  N   . THR A 1 542 ? -31.315 -50.723 -21.680 1.00 42.17  ? 805  THR A N   1 
ATOM   3921 C  CA  . THR A 1 542 ? -32.451 -51.312 -22.437 1.00 44.03  ? 805  THR A CA  1 
ATOM   3922 C  C   . THR A 1 542 ? -32.781 -52.675 -21.833 1.00 43.79  ? 805  THR A C   1 
ATOM   3923 O  O   . THR A 1 542 ? -31.910 -53.251 -21.139 1.00 42.97  ? 805  THR A O   1 
ATOM   3924 C  CB  . THR A 1 542 ? -32.128 -51.488 -23.928 1.00 49.66  ? 805  THR A CB  1 
ATOM   3925 O  OG1 . THR A 1 542 ? -33.194 -52.173 -24.586 1.00 46.86  ? 805  THR A OG1 1 
ATOM   3926 C  CG2 . THR A 1 542 ? -30.882 -52.313 -24.158 1.00 49.56  ? 805  THR A CG2 1 
ATOM   3927 N  N   . THR A 1 543 ? -33.987 -53.165 -22.103 1.00 38.80  ? 806  THR A N   1 
ATOM   3928 C  CA  . THR A 1 543 ? -34.480 -54.513 -21.717 1.00 44.92  ? 806  THR A CA  1 
ATOM   3929 C  C   . THR A 1 543 ? -34.503 -55.438 -22.940 1.00 39.59  ? 806  THR A C   1 
ATOM   3930 O  O   . THR A 1 543 ? -34.774 -56.628 -22.760 1.00 39.56  ? 806  THR A O   1 
ATOM   3931 C  CB  . THR A 1 543 ? -35.869 -54.408 -21.079 1.00 51.33  ? 806  THR A CB  1 
ATOM   3932 O  OG1 . THR A 1 543 ? -36.628 -53.481 -21.863 1.00 46.75  ? 806  THR A OG1 1 
ATOM   3933 C  CG2 . THR A 1 543 ? -35.793 -53.975 -19.627 1.00 57.28  ? 806  THR A CG2 1 
ATOM   3934 N  N   . GLU A 1 544 ? -34.184 -54.915 -24.120 1.00 35.75  ? 807  GLU A N   1 
ATOM   3935 C  CA  . GLU A 1 544 ? -34.042 -55.723 -25.355 1.00 38.33  ? 807  GLU A CA  1 
ATOM   3936 C  C   . GLU A 1 544 ? -32.971 -56.781 -25.127 1.00 39.66  ? 807  GLU A C   1 
ATOM   3937 O  O   . GLU A 1 544 ? -32.108 -56.609 -24.231 1.00 39.13  ? 807  GLU A O   1 
ATOM   3938 C  CB  . GLU A 1 544 ? -33.680 -54.825 -26.530 1.00 43.65  ? 807  GLU A CB  1 
ATOM   3939 C  CG  . GLU A 1 544 ? -33.762 -55.506 -27.868 1.00 47.08  ? 807  GLU A CG  1 
ATOM   3940 C  CD  . GLU A 1 544 ? -33.700 -54.521 -29.032 1.00 60.63  ? 807  GLU A CD  1 
ATOM   3941 O  OE1 . GLU A 1 544 ? -34.158 -54.916 -30.149 1.00 60.17  ? 807  GLU A OE1 1 
ATOM   3942 O  OE2 . GLU A 1 544 ? -33.194 -53.350 -28.827 1.00 47.45  ? 807  GLU A OE2 1 
ATOM   3943 N  N   . ASP A 1 545 ? -33.055 -57.852 -25.896 1.00 40.54  ? 808  ASP A N   1 
ATOM   3944 C  CA  . ASP A 1 545 ? -32.114 -58.997 -25.858 1.00 43.02  ? 808  ASP A CA  1 
ATOM   3945 C  C   . ASP A 1 545 ? -30.713 -58.486 -26.241 1.00 41.18  ? 808  ASP A C   1 
ATOM   3946 O  O   . ASP A 1 545 ? -30.609 -57.712 -27.230 1.00 39.57  ? 808  ASP A O   1 
ATOM   3947 C  CB  . ASP A 1 545 ? -32.632 -60.098 -26.787 1.00 49.69  ? 808  ASP A CB  1 
ATOM   3948 C  CG  . ASP A 1 545 ? -31.686 -61.270 -26.927 1.00 62.39  ? 808  ASP A CG  1 
ATOM   3949 O  OD1 . ASP A 1 545 ? -31.257 -61.518 -28.067 1.00 74.56  ? 808  ASP A OD1 1 
ATOM   3950 O  OD2 . ASP A 1 545 ? -31.398 -61.932 -25.895 1.00 77.95  ? 808  ASP A OD2 1 
ATOM   3951 N  N   . MET A 1 546 ? -29.669 -58.892 -25.513 1.00 38.50  ? 809  MET A N   1 
ATOM   3952 C  CA  . MET A 1 546 ? -28.318 -58.272 -25.679 1.00 39.05  ? 809  MET A CA  1 
ATOM   3953 C  C   . MET A 1 546 ? -27.704 -58.806 -26.973 1.00 34.09  ? 809  MET A C   1 
ATOM   3954 O  O   . MET A 1 546 ? -27.048 -58.000 -27.670 1.00 33.51  ? 809  MET A O   1 
ATOM   3955 C  CB  . MET A 1 546 ? -27.410 -58.499 -24.470 1.00 39.97  ? 809  MET A CB  1 
ATOM   3956 C  CG  . MET A 1 546 ? -27.729 -57.550 -23.275 1.00 40.95  ? 809  MET A CG  1 
ATOM   3957 S  SD  . MET A 1 546 ? -27.504 -55.792 -23.649 1.00 46.80  ? 809  MET A SD  1 
ATOM   3958 C  CE  . MET A 1 546 ? -29.198 -55.258 -23.740 1.00 56.86  ? 809  MET A CE  1 
ATOM   3959 N  N   . LEU A 1 547 ? -28.037 -60.028 -27.395 1.00 30.64  ? 810  LEU A N   1 
ATOM   3960 C  CA  . LEU A 1 547 ? -27.525 -60.494 -28.715 1.00 33.15  ? 810  LEU A CA  1 
ATOM   3961 C  C   . LEU A 1 547 ? -28.095 -59.609 -29.818 1.00 34.12  ? 810  LEU A C   1 
ATOM   3962 O  O   . LEU A 1 547 ? -27.369 -59.376 -30.784 1.00 34.98  ? 810  LEU A O   1 
ATOM   3963 C  CB  . LEU A 1 547 ? -27.852 -61.956 -29.015 1.00 33.57  ? 810  LEU A CB  1 
ATOM   3964 C  CG  . LEU A 1 547 ? -27.159 -62.475 -30.276 1.00 37.60  ? 810  LEU A CG  1 
ATOM   3965 C  CD1 . LEU A 1 547 ? -25.640 -62.474 -30.097 1.00 38.29  ? 810  LEU A CD1 1 
ATOM   3966 C  CD2 . LEU A 1 547 ? -27.637 -63.859 -30.645 1.00 37.87  ? 810  LEU A CD2 1 
ATOM   3967 N  N   . THR A 1 548 ? -29.344 -59.149 -29.706 1.00 35.13  ? 811  THR A N   1 
ATOM   3968 C  CA  . THR A 1 548 ? -29.971 -58.298 -30.754 1.00 37.42  ? 811  THR A CA  1 
ATOM   3969 C  C   . THR A 1 548 ? -29.305 -56.914 -30.798 1.00 34.29  ? 811  THR A C   1 
ATOM   3970 O  O   . THR A 1 548 ? -29.094 -56.423 -31.890 1.00 31.42  ? 811  THR A O   1 
ATOM   3971 C  CB  . THR A 1 548 ? -31.481 -58.155 -30.538 1.00 41.16  ? 811  THR A CB  1 
ATOM   3972 O  OG1 . THR A 1 548 ? -31.976 -59.490 -30.551 1.00 38.76  ? 811  THR A OG1 1 
ATOM   3973 C  CG2 . THR A 1 548 ? -32.163 -57.292 -31.587 1.00 39.78  ? 811  THR A CG2 1 
ATOM   3974 N  N   . VAL A 1 549 ? -29.112 -56.275 -29.644 1.00 31.77  ? 812  VAL A N   1 
ATOM   3975 C  CA  . VAL A 1 549 ? -28.320 -55.027 -29.491 1.00 36.52  ? 812  VAL A CA  1 
ATOM   3976 C  C   . VAL A 1 549 ? -26.905 -55.228 -30.057 1.00 34.64  ? 812  VAL A C   1 
ATOM   3977 O  O   . VAL A 1 549 ? -26.456 -54.351 -30.798 1.00 32.76  ? 812  VAL A O   1 
ATOM   3978 C  CB  . VAL A 1 549 ? -28.239 -54.576 -28.023 1.00 37.89  ? 812  VAL A CB  1 
ATOM   3979 C  CG1 . VAL A 1 549 ? -27.448 -53.279 -27.935 1.00 39.18  ? 812  VAL A CG1 1 
ATOM   3980 C  CG2 . VAL A 1 549 ? -29.621 -54.411 -27.409 1.00 39.31  ? 812  VAL A CG2 1 
ATOM   3981 N  N   . TRP A 1 550 ? -26.209 -56.315 -29.706 1.00 33.75  ? 813  TRP A N   1 
ATOM   3982 C  CA  . TRP A 1 550 ? -24.833 -56.569 -30.233 1.00 32.80  ? 813  TRP A CA  1 
ATOM   3983 C  C   . TRP A 1 550 ? -24.865 -56.465 -31.767 1.00 37.09  ? 813  TRP A C   1 
ATOM   3984 O  O   . TRP A 1 550 ? -24.003 -55.755 -32.367 1.00 37.38  ? 813  TRP A O   1 
ATOM   3985 C  CB  . TRP A 1 550 ? -24.276 -57.919 -29.759 1.00 30.95  ? 813  TRP A CB  1 
ATOM   3986 C  CG  . TRP A 1 550 ? -22.806 -58.083 -29.998 1.00 31.16  ? 813  TRP A CG  1 
ATOM   3987 C  CD1 . TRP A 1 550 ? -21.802 -57.898 -29.087 1.00 33.50  ? 813  TRP A CD1 1 
ATOM   3988 C  CD2 . TRP A 1 550 ? -22.162 -58.466 -31.229 1.00 34.63  ? 813  TRP A CD2 1 
ATOM   3989 N  NE1 . TRP A 1 550 ? -20.578 -58.132 -29.665 1.00 37.05  ? 813  TRP A NE1 1 
ATOM   3990 C  CE2 . TRP A 1 550 ? -20.763 -58.456 -30.988 1.00 35.09  ? 813  TRP A CE2 1 
ATOM   3991 C  CE3 . TRP A 1 550 ? -22.621 -58.850 -32.495 1.00 33.56  ? 813  TRP A CE3 1 
ATOM   3992 C  CZ2 . TRP A 1 550 ? -19.833 -58.800 -31.966 1.00 32.22  ? 813  TRP A CZ2 1 
ATOM   3993 C  CZ3 . TRP A 1 550 ? -21.699 -59.173 -33.467 1.00 34.69  ? 813  TRP A CZ3 1 
ATOM   3994 C  CH2 . TRP A 1 550 ? -20.326 -59.151 -33.205 1.00 35.47  ? 813  TRP A CH2 1 
ATOM   3995 N  N   . ASN A 1 551 ? -25.807 -57.169 -32.388 1.00 33.60  ? 814  ASN A N   1 
ATOM   3996 C  CA  . ASN A 1 551 ? -25.933 -57.246 -33.858 1.00 36.11  ? 814  ASN A CA  1 
ATOM   3997 C  C   . ASN A 1 551 ? -26.139 -55.829 -34.401 1.00 32.75  ? 814  ASN A C   1 
ATOM   3998 O  O   . ASN A 1 551 ? -25.473 -55.452 -35.392 1.00 34.00  ? 814  ASN A O   1 
ATOM   3999 C  CB  . ASN A 1 551 ? -27.030 -58.230 -34.288 1.00 38.80  ? 814  ASN A CB  1 
ATOM   4000 C  CG  . ASN A 1 551 ? -26.499 -59.628 -34.538 1.00 44.18  ? 814  ASN A CG  1 
ATOM   4001 O  OD1 . ASN A 1 551 ? -25.659 -59.820 -35.419 1.00 48.06  ? 814  ASN A OD1 1 
ATOM   4002 N  ND2 . ASN A 1 551 ? -26.992 -60.612 -33.790 1.00 45.93  ? 814  ASN A ND2 1 
ATOM   4003 N  N   . ARG A 1 552 ? -27.011 -55.050 -33.781 1.00 32.87  ? 815  ARG A N   1 
ATOM   4004 C  CA  . ARG A 1 552 ? -27.306 -53.691 -34.294 1.00 35.69  ? 815  ARG A CA  1 
ATOM   4005 C  C   . ARG A 1 552 ? -26.009 -52.856 -34.264 1.00 39.08  ? 815  ARG A C   1 
ATOM   4006 O  O   . ARG A 1 552 ? -25.625 -52.247 -35.336 1.00 37.08  ? 815  ARG A O   1 
ATOM   4007 C  CB  . ARG A 1 552 ? -28.422 -53.076 -33.464 1.00 37.17  ? 815  ARG A CB  1 
ATOM   4008 C  CG  . ARG A 1 552 ? -28.881 -51.712 -33.953 1.00 44.04  ? 815  ARG A CG  1 
ATOM   4009 C  CD  . ARG A 1 552 ? -29.960 -51.123 -33.060 1.00 48.82  ? 815  ARG A CD  1 
ATOM   4010 N  NE  . ARG A 1 552 ? -31.036 -52.101 -33.026 1.00 58.58  ? 815  ARG A NE  1 
ATOM   4011 C  CZ  . ARG A 1 552 ? -31.654 -52.572 -31.943 1.00 60.51  ? 815  ARG A CZ  1 
ATOM   4012 N  NH1 . ARG A 1 552 ? -31.375 -52.119 -30.724 1.00 57.13  ? 815  ARG A NH1 1 
ATOM   4013 N  NH2 . ARG A 1 552 ? -32.600 -53.477 -32.125 1.00 61.72  ? 815  ARG A NH2 1 
ATOM   4014 N  N   . VAL A 1 553 ? -25.319 -52.887 -33.118 1.00 32.71  ? 816  VAL A N   1 
ATOM   4015 C  CA  . VAL A 1 553 ? -24.160 -52.001 -32.794 1.00 36.12  ? 816  VAL A CA  1 
ATOM   4016 C  C   . VAL A 1 553 ? -22.917 -52.392 -33.616 1.00 34.18  ? 816  VAL A C   1 
ATOM   4017 O  O   . VAL A 1 553 ? -22.278 -51.475 -34.206 1.00 37.21  ? 816  VAL A O   1 
ATOM   4018 C  CB  . VAL A 1 553 ? -23.907 -52.001 -31.277 1.00 36.14  ? 816  VAL A CB  1 
ATOM   4019 C  CG1 . VAL A 1 553 ? -22.588 -51.359 -30.927 1.00 38.23  ? 816  VAL A CG1 1 
ATOM   4020 C  CG2 . VAL A 1 553 ? -25.026 -51.280 -30.568 1.00 34.80  ? 816  VAL A CG2 1 
ATOM   4021 N  N   . TRP A 1 554 ? -22.595 -53.686 -33.681 1.00 32.48  ? 817  TRP A N   1 
ATOM   4022 C  CA  . TRP A 1 554 ? -21.304 -54.190 -34.213 1.00 31.01  ? 817  TRP A CA  1 
ATOM   4023 C  C   . TRP A 1 554 ? -21.435 -54.534 -35.695 1.00 34.98  ? 817  TRP A C   1 
ATOM   4024 O  O   . TRP A 1 554 ? -20.380 -54.558 -36.360 1.00 29.95  ? 817  TRP A O   1 
ATOM   4025 C  CB  . TRP A 1 554 ? -20.768 -55.362 -33.370 1.00 28.71  ? 817  TRP A CB  1 
ATOM   4026 C  CG  . TRP A 1 554 ? -20.248 -54.921 -32.033 1.00 30.87  ? 817  TRP A CG  1 
ATOM   4027 C  CD1 . TRP A 1 554 ? -20.848 -55.061 -30.817 1.00 28.64  ? 817  TRP A CD1 1 
ATOM   4028 C  CD2 . TRP A 1 554 ? -19.031 -54.187 -31.786 1.00 28.88  ? 817  TRP A CD2 1 
ATOM   4029 N  NE1 . TRP A 1 554 ? -20.084 -54.495 -29.832 1.00 28.67  ? 817  TRP A NE1 1 
ATOM   4030 C  CE2 . TRP A 1 554 ? -18.966 -53.939 -30.394 1.00 30.77  ? 817  TRP A CE2 1 
ATOM   4031 C  CE3 . TRP A 1 554 ? -17.983 -53.745 -32.595 1.00 28.69  ? 817  TRP A CE3 1 
ATOM   4032 C  CZ2 . TRP A 1 554 ? -17.893 -53.268 -29.800 1.00 28.92  ? 817  TRP A CZ2 1 
ATOM   4033 C  CZ3 . TRP A 1 554 ? -16.938 -53.041 -32.009 1.00 30.99  ? 817  TRP A CZ3 1 
ATOM   4034 C  CH2 . TRP A 1 554 ? -16.886 -52.824 -30.631 1.00 27.97  ? 817  TRP A CH2 1 
ATOM   4035 N  N   . ILE A 1 555 ? -22.658 -54.801 -36.190 1.00 39.37  ? 818  ILE A N   1 
ATOM   4036 C  CA  . ILE A 1 555 ? -22.871 -55.272 -37.595 1.00 37.44  ? 818  ILE A CA  1 
ATOM   4037 C  C   . ILE A 1 555 ? -23.704 -54.236 -38.350 1.00 40.68  ? 818  ILE A C   1 
ATOM   4038 O  O   . ILE A 1 555 ? -23.154 -53.606 -39.268 1.00 36.73  ? 818  ILE A O   1 
ATOM   4039 C  CB  . ILE A 1 555 ? -23.550 -56.653 -37.665 1.00 41.22  ? 818  ILE A CB  1 
ATOM   4040 C  CG1 . ILE A 1 555 ? -22.927 -57.672 -36.708 1.00 42.72  ? 818  ILE A CG1 1 
ATOM   4041 C  CG2 . ILE A 1 555 ? -23.558 -57.170 -39.108 1.00 40.53  ? 818  ILE A CG2 1 
ATOM   4042 C  CD1 . ILE A 1 555 ? -21.535 -58.057 -37.084 1.00 46.16  ? 818  ILE A CD1 1 
ATOM   4043 N  N   . GLN A 1 556 ? -24.993 -54.106 -38.012 1.00 42.49  ? 819  GLN A N   1 
ATOM   4044 C  CA  . GLN A 1 556 ? -25.987 -53.352 -38.824 1.00 41.54  ? 819  GLN A CA  1 
ATOM   4045 C  C   . GLN A 1 556 ? -25.531 -51.892 -38.955 1.00 37.54  ? 819  GLN A C   1 
ATOM   4046 O  O   . GLN A 1 556 ? -25.378 -51.414 -40.067 1.00 39.56  ? 819  GLN A O   1 
ATOM   4047 C  CB  . GLN A 1 556 ? -27.366 -53.526 -38.190 1.00 45.35  ? 819  GLN A CB  1 
ATOM   4048 C  CG  . GLN A 1 556 ? -28.518 -52.916 -38.982 1.00 53.60  ? 819  GLN A CG  1 
ATOM   4049 C  CD  . GLN A 1 556 ? -29.761 -52.715 -38.133 1.00 64.40  ? 819  GLN A CD  1 
ATOM   4050 O  OE1 . GLN A 1 556 ? -30.296 -51.608 -38.017 1.00 69.65  ? 819  GLN A OE1 1 
ATOM   4051 N  NE2 . GLN A 1 556 ? -30.227 -53.779 -37.495 1.00 59.55  ? 819  GLN A NE2 1 
ATOM   4052 N  N   . GLU A 1 557 ? -25.251 -51.231 -37.841 1.00 37.06  ? 820  GLU A N   1 
ATOM   4053 C  CA  . GLU A 1 557 ? -25.013 -49.772 -37.772 1.00 38.55  ? 820  GLU A CA  1 
ATOM   4054 C  C   . GLU A 1 557 ? -23.514 -49.439 -37.833 1.00 38.72  ? 820  GLU A C   1 
ATOM   4055 O  O   . GLU A 1 557 ? -23.186 -48.243 -37.655 1.00 39.77  ? 820  GLU A O   1 
ATOM   4056 C  CB  . GLU A 1 557 ? -25.567 -49.220 -36.457 1.00 39.89  ? 820  GLU A CB  1 
ATOM   4057 C  CG  . GLU A 1 557 ? -27.072 -49.256 -36.334 1.00 46.07  ? 820  GLU A CG  1 
ATOM   4058 C  CD  . GLU A 1 557 ? -27.584 -48.618 -35.036 1.00 57.25  ? 820  GLU A CD  1 
ATOM   4059 O  OE1 . GLU A 1 557 ? -26.742 -48.332 -34.106 1.00 58.47  ? 820  GLU A OE1 1 
ATOM   4060 O  OE2 . GLU A 1 557 ? -28.829 -48.414 -34.930 1.00 66.89  ? 820  GLU A OE2 1 
ATOM   4061 N  N   . ASN A 1 558 ? -22.642 -50.436 -38.036 1.00 38.83  ? 821  ASN A N   1 
ATOM   4062 C  CA  . ASN A 1 558 ? -21.155 -50.296 -38.004 1.00 34.08  ? 821  ASN A CA  1 
ATOM   4063 C  C   . ASN A 1 558 ? -20.696 -49.893 -39.398 1.00 33.95  ? 821  ASN A C   1 
ATOM   4064 O  O   . ASN A 1 558 ? -20.724 -50.699 -40.316 1.00 34.67  ? 821  ASN A O   1 
ATOM   4065 C  CB  . ASN A 1 558 ? -20.513 -51.598 -37.529 1.00 33.28  ? 821  ASN A CB  1 
ATOM   4066 C  CG  . ASN A 1 558 ? -18.995 -51.591 -37.488 1.00 33.77  ? 821  ASN A CG  1 
ATOM   4067 O  OD1 . ASN A 1 558 ? -18.360 -50.684 -38.018 1.00 32.26  ? 821  ASN A OD1 1 
ATOM   4068 N  ND2 . ASN A 1 558 ? -18.409 -52.623 -36.883 1.00 31.02  ? 821  ASN A ND2 1 
ATOM   4069 N  N   . PRO A 1 559 ? -20.312 -48.629 -39.646 1.00 37.70  ? 822  PRO A N   1 
ATOM   4070 C  CA  . PRO A 1 559 ? -19.907 -48.237 -40.993 1.00 37.88  ? 822  PRO A CA  1 
ATOM   4071 C  C   . PRO A 1 559 ? -18.630 -48.920 -41.496 1.00 39.26  ? 822  PRO A C   1 
ATOM   4072 O  O   . PRO A 1 559 ? -18.396 -48.849 -42.680 1.00 41.09  ? 822  PRO A O   1 
ATOM   4073 C  CB  . PRO A 1 559 ? -19.726 -46.716 -40.902 1.00 37.82  ? 822  PRO A CB  1 
ATOM   4074 C  CG  . PRO A 1 559 ? -19.568 -46.437 -39.422 1.00 37.32  ? 822  PRO A CG  1 
ATOM   4075 C  CD  . PRO A 1 559 ? -20.408 -47.484 -38.731 1.00 38.21  ? 822  PRO A CD  1 
ATOM   4076 N  N   . TRP A 1 560 ? -17.846 -49.571 -40.632 1.00 40.84  ? 823  TRP A N   1 
ATOM   4077 C  CA  . TRP A 1 560 ? -16.578 -50.238 -41.049 1.00 37.85  ? 823  TRP A CA  1 
ATOM   4078 C  C   . TRP A 1 560 ? -16.790 -51.715 -41.422 1.00 40.97  ? 823  TRP A C   1 
ATOM   4079 O  O   . TRP A 1 560 ? -15.781 -52.351 -41.762 1.00 41.04  ? 823  TRP A O   1 
ATOM   4080 C  CB  . TRP A 1 560 ? -15.543 -50.104 -39.939 1.00 36.60  ? 823  TRP A CB  1 
ATOM   4081 C  CG  . TRP A 1 560 ? -15.029 -48.708 -39.816 1.00 37.00  ? 823  TRP A CG  1 
ATOM   4082 C  CD1 . TRP A 1 560 ? -14.054 -48.127 -40.571 1.00 32.82  ? 823  TRP A CD1 1 
ATOM   4083 C  CD2 . TRP A 1 560 ? -15.494 -47.702 -38.900 1.00 35.32  ? 823  TRP A CD2 1 
ATOM   4084 N  NE1 . TRP A 1 560 ? -13.878 -46.827 -40.176 1.00 37.04  ? 823  TRP A NE1 1 
ATOM   4085 C  CE2 . TRP A 1 560 ? -14.739 -46.543 -39.147 1.00 33.87  ? 823  TRP A CE2 1 
ATOM   4086 C  CE3 . TRP A 1 560 ? -16.433 -47.683 -37.869 1.00 36.37  ? 823  TRP A CE3 1 
ATOM   4087 C  CZ2 . TRP A 1 560 ? -14.902 -45.382 -38.403 1.00 35.27  ? 823  TRP A CZ2 1 
ATOM   4088 C  CZ3 . TRP A 1 560 ? -16.629 -46.515 -37.163 1.00 36.43  ? 823  TRP A CZ3 1 
ATOM   4089 C  CH2 . TRP A 1 560 ? -15.865 -45.383 -37.419 1.00 34.37  ? 823  TRP A CH2 1 
ATOM   4090 N  N   . MET A 1 561 ? -18.027 -52.229 -41.343 1.00 41.92  ? 824  MET A N   1 
ATOM   4091 C  CA  . MET A 1 561 ? -18.424 -53.649 -41.604 1.00 43.67  ? 824  MET A CA  1 
ATOM   4092 C  C   . MET A 1 561 ? -19.212 -53.701 -42.921 1.00 41.54  ? 824  MET A C   1 
ATOM   4093 O  O   . MET A 1 561 ? -20.334 -53.186 -42.955 1.00 40.33  ? 824  MET A O   1 
ATOM   4094 C  CB  . MET A 1 561 ? -19.307 -54.144 -40.445 1.00 46.76  ? 824  MET A CB  1 
ATOM   4095 C  CG  . MET A 1 561 ? -19.515 -55.657 -40.361 1.00 47.08  ? 824  MET A CG  1 
ATOM   4096 S  SD  . MET A 1 561 ? -17.988 -56.371 -39.808 1.00 63.96  ? 824  MET A SD  1 
ATOM   4097 C  CE  . MET A 1 561 ? -18.145 -56.248 -38.026 1.00 64.22  ? 824  MET A CE  1 
ATOM   4098 N  N   . GLU A 1 562 ? -18.649 -54.252 -43.989 1.00 47.06  ? 825  GLU A N   1 
ATOM   4099 C  CA  . GLU A 1 562 ? -19.310 -54.253 -45.328 1.00 52.72  ? 825  GLU A CA  1 
ATOM   4100 C  C   . GLU A 1 562 ? -20.356 -55.370 -45.400 1.00 49.09  ? 825  GLU A C   1 
ATOM   4101 O  O   . GLU A 1 562 ? -21.417 -55.120 -45.953 1.00 48.31  ? 825  GLU A O   1 
ATOM   4102 C  CB  . GLU A 1 562 ? -18.310 -54.413 -46.470 1.00 61.79  ? 825  GLU A CB  1 
ATOM   4103 C  CG  . GLU A 1 562 ? -18.799 -53.848 -47.793 1.00 74.00  ? 825  GLU A CG  1 
ATOM   4104 C  CD  . GLU A 1 562 ? -17.852 -54.054 -48.975 1.00 90.08  ? 825  GLU A CD  1 
ATOM   4105 O  OE1 . GLU A 1 562 ? -18.321 -54.595 -50.005 1.00 102.85 ? 825  GLU A OE1 1 
ATOM   4106 O  OE2 . GLU A 1 562 ? -16.646 -53.664 -48.881 1.00 90.47  ? 825  GLU A OE2 1 
ATOM   4107 N  N   . ASP A 1 563 ? -20.076 -56.542 -44.837 1.00 44.92  ? 826  ASP A N   1 
ATOM   4108 C  CA  . ASP A 1 563 ? -21.012 -57.689 -44.829 1.00 42.47  ? 826  ASP A CA  1 
ATOM   4109 C  C   . ASP A 1 563 ? -21.952 -57.560 -43.630 1.00 42.05  ? 826  ASP A C   1 
ATOM   4110 O  O   . ASP A 1 563 ? -21.455 -57.496 -42.522 1.00 41.91  ? 826  ASP A O   1 
ATOM   4111 C  CB  . ASP A 1 563 ? -20.201 -58.974 -44.814 1.00 41.68  ? 826  ASP A CB  1 
ATOM   4112 C  CG  . ASP A 1 563 ? -20.987 -60.205 -44.417 1.00 43.69  ? 826  ASP A CG  1 
ATOM   4113 O  OD1 . ASP A 1 563 ? -22.241 -60.148 -44.371 1.00 42.17  ? 826  ASP A OD1 1 
ATOM   4114 O  OD2 . ASP A 1 563 ? -20.328 -61.201 -44.120 1.00 46.61  ? 826  ASP A OD2 1 
ATOM   4115 N  N   . LYS A 1 564 ? -23.270 -57.576 -43.842 1.00 42.37  ? 827  LYS A N   1 
ATOM   4116 C  CA  . LYS A 1 564 ? -24.256 -57.235 -42.779 1.00 41.50  ? 827  LYS A CA  1 
ATOM   4117 C  C   . LYS A 1 564 ? -24.942 -58.498 -42.245 1.00 37.49  ? 827  LYS A C   1 
ATOM   4118 O  O   . LYS A 1 564 ? -26.026 -58.377 -41.623 1.00 39.10  ? 827  LYS A O   1 
ATOM   4119 C  CB  . LYS A 1 564 ? -25.276 -56.208 -43.287 1.00 45.04  ? 827  LYS A CB  1 
ATOM   4120 C  CG  . LYS A 1 564 ? -24.690 -54.865 -43.692 1.00 43.88  ? 827  LYS A CG  1 
ATOM   4121 C  CD  . LYS A 1 564 ? -23.929 -54.187 -42.599 1.00 43.06  ? 827  LYS A CD  1 
ATOM   4122 C  CE  . LYS A 1 564 ? -23.761 -52.716 -42.848 1.00 40.39  ? 827  LYS A CE  1 
ATOM   4123 N  NZ  . LYS A 1 564 ? -22.935 -52.074 -41.802 1.00 44.71  ? 827  LYS A NZ  1 
ATOM   4124 N  N   . THR A 1 565 ? -24.320 -59.656 -42.419 1.00 38.09  ? 828  THR A N   1 
ATOM   4125 C  CA  . THR A 1 565 ? -24.880 -60.962 -41.982 1.00 43.56  ? 828  THR A CA  1 
ATOM   4126 C  C   . THR A 1 565 ? -24.986 -60.977 -40.469 1.00 40.40  ? 828  THR A C   1 
ATOM   4127 O  O   . THR A 1 565 ? -23.959 -60.910 -39.794 1.00 37.77  ? 828  THR A O   1 
ATOM   4128 C  CB  . THR A 1 565 ? -23.993 -62.143 -42.393 1.00 49.63  ? 828  THR A CB  1 
ATOM   4129 O  OG1 . THR A 1 565 ? -23.829 -62.123 -43.813 1.00 49.94  ? 828  THR A OG1 1 
ATOM   4130 C  CG2 . THR A 1 565 ? -24.559 -63.466 -41.927 1.00 47.98  ? 828  THR A CG2 1 
ATOM   4131 N  N   . PRO A 1 566 ? -26.205 -61.114 -39.901 1.00 43.87  ? 829  PRO A N   1 
ATOM   4132 C  CA  . PRO A 1 566 ? -26.385 -61.064 -38.454 1.00 43.63  ? 829  PRO A CA  1 
ATOM   4133 C  C   . PRO A 1 566 ? -25.636 -62.238 -37.836 1.00 44.96  ? 829  PRO A C   1 
ATOM   4134 O  O   . PRO A 1 566 ? -25.436 -63.244 -38.479 1.00 43.53  ? 829  PRO A O   1 
ATOM   4135 C  CB  . PRO A 1 566 ? -27.896 -61.190 -38.226 1.00 43.58  ? 829  PRO A CB  1 
ATOM   4136 C  CG  . PRO A 1 566 ? -28.501 -60.857 -39.570 1.00 42.54  ? 829  PRO A CG  1 
ATOM   4137 C  CD  . PRO A 1 566 ? -27.482 -61.321 -40.595 1.00 43.16  ? 829  PRO A CD  1 
ATOM   4138 N  N   . VAL A 1 567 ? -25.218 -62.056 -36.599 1.00 47.36  ? 830  VAL A N   1 
ATOM   4139 C  CA  . VAL A 1 567 ? -24.674 -63.160 -35.766 1.00 48.99  ? 830  VAL A CA  1 
ATOM   4140 C  C   . VAL A 1 567 ? -25.875 -63.840 -35.088 1.00 46.28  ? 830  VAL A C   1 
ATOM   4141 O  O   . VAL A 1 567 ? -26.830 -63.139 -34.688 1.00 47.24  ? 830  VAL A O   1 
ATOM   4142 C  CB  . VAL A 1 567 ? -23.601 -62.614 -34.806 1.00 48.28  ? 830  VAL A CB  1 
ATOM   4143 C  CG1 . VAL A 1 567 ? -23.347 -63.556 -33.657 1.00 49.51  ? 830  VAL A CG1 1 
ATOM   4144 C  CG2 . VAL A 1 567 ? -22.307 -62.323 -35.552 1.00 45.11  ? 830  VAL A CG2 1 
ATOM   4145 N  N   . GLU A 1 568 ? -25.859 -65.170 -35.038 1.00 48.20  ? 831  GLU A N   1 
ATOM   4146 C  CA  . GLU A 1 568 ? -27.029 -66.013 -34.659 1.00 52.81  ? 831  GLU A CA  1 
ATOM   4147 C  C   . GLU A 1 568 ? -26.875 -66.489 -33.215 1.00 44.32  ? 831  GLU A C   1 
ATOM   4148 O  O   . GLU A 1 568 ? -27.900 -66.782 -32.633 1.00 47.04  ? 831  GLU A O   1 
ATOM   4149 C  CB  . GLU A 1 568 ? -27.204 -67.192 -35.637 1.00 54.25  ? 831  GLU A CB  1 
ATOM   4150 C  CG  . GLU A 1 568 ? -27.568 -66.770 -37.064 1.00 57.40  ? 831  GLU A CG  1 
ATOM   4151 C  CD  . GLU A 1 568 ? -28.954 -66.147 -37.182 1.00 62.33  ? 831  GLU A CD  1 
ATOM   4152 O  OE1 . GLU A 1 568 ? -29.738 -66.306 -36.245 1.00 66.95  ? 831  GLU A OE1 1 
ATOM   4153 O  OE2 . GLU A 1 568 ? -29.253 -65.506 -38.197 1.00 60.11  ? 831  GLU A OE2 1 
ATOM   4154 N  N   . SER A 1 569 ? -25.658 -66.577 -32.663 1.00 40.33  ? 832  SER A N   1 
ATOM   4155 C  CA  . SER A 1 569 ? -25.430 -66.906 -31.226 1.00 39.20  ? 832  SER A CA  1 
ATOM   4156 C  C   . SER A 1 569 ? -24.179 -66.229 -30.662 1.00 38.37  ? 832  SER A C   1 
ATOM   4157 O  O   . SER A 1 569 ? -23.313 -65.743 -31.425 1.00 35.94  ? 832  SER A O   1 
ATOM   4158 C  CB  . SER A 1 569 ? -25.306 -68.376 -31.042 1.00 39.54  ? 832  SER A CB  1 
ATOM   4159 O  OG  . SER A 1 569 ? -24.054 -68.803 -31.525 1.00 37.32  ? 832  SER A OG  1 
ATOM   4160 N  N   . TRP A 1 570 ? -24.058 -66.244 -29.345 1.00 37.93  ? 833  TRP A N   1 
ATOM   4161 C  CA  . TRP A 1 570 ? -22.898 -65.635 -28.655 1.00 39.17  ? 833  TRP A CA  1 
ATOM   4162 C  C   . TRP A 1 570 ? -21.632 -66.432 -29.007 1.00 39.52  ? 833  TRP A C   1 
ATOM   4163 O  O   . TRP A 1 570 ? -20.536 -65.870 -28.978 1.00 38.57  ? 833  TRP A O   1 
ATOM   4164 C  CB  . TRP A 1 570 ? -23.164 -65.556 -27.149 1.00 35.92  ? 833  TRP A CB  1 
ATOM   4165 C  CG  . TRP A 1 570 ? -24.052 -64.413 -26.773 1.00 40.02  ? 833  TRP A CG  1 
ATOM   4166 C  CD1 . TRP A 1 570 ? -25.385 -64.457 -26.474 1.00 37.03  ? 833  TRP A CD1 1 
ATOM   4167 C  CD2 . TRP A 1 570 ? -23.653 -63.036 -26.622 1.00 40.30  ? 833  TRP A CD2 1 
ATOM   4168 N  NE1 . TRP A 1 570 ? -25.844 -63.204 -26.161 1.00 38.19  ? 833  TRP A NE1 1 
ATOM   4169 C  CE2 . TRP A 1 570 ? -24.801 -62.315 -26.225 1.00 37.16  ? 833  TRP A CE2 1 
ATOM   4170 C  CE3 . TRP A 1 570 ? -22.437 -62.351 -26.754 1.00 36.94  ? 833  TRP A CE3 1 
ATOM   4171 C  CZ2 . TRP A 1 570 ? -24.765 -60.944 -25.963 1.00 38.43  ? 833  TRP A CZ2 1 
ATOM   4172 C  CZ3 . TRP A 1 570 ? -22.408 -60.996 -26.511 1.00 38.48  ? 833  TRP A CZ3 1 
ATOM   4173 C  CH2 . TRP A 1 570 ? -23.558 -60.304 -26.113 1.00 38.78  ? 833  TRP A CH2 1 
ATOM   4174 N  N   . GLU A 1 571 ? -21.759 -67.680 -29.422 1.00 40.03  ? 834  GLU A N   1 
ATOM   4175 C  CA  . GLU A 1 571 ? -20.555 -68.484 -29.733 1.00 45.25  ? 834  GLU A CA  1 
ATOM   4176 C  C   . GLU A 1 571 ? -19.833 -68.045 -31.020 1.00 42.44  ? 834  GLU A C   1 
ATOM   4177 O  O   . GLU A 1 571 ? -18.654 -68.357 -31.148 1.00 43.03  ? 834  GLU A O   1 
ATOM   4178 C  CB  . GLU A 1 571 ? -20.904 -69.966 -29.746 1.00 55.78  ? 834  GLU A CB  1 
ATOM   4179 C  CG  . GLU A 1 571 ? -20.983 -70.541 -28.342 1.00 67.71  ? 834  GLU A CG  1 
ATOM   4180 C  CD  . GLU A 1 571 ? -21.191 -72.047 -28.293 1.00 81.85  ? 834  GLU A CD  1 
ATOM   4181 O  OE1 . GLU A 1 571 ? -20.657 -72.757 -29.192 1.00 87.43  ? 834  GLU A OE1 1 
ATOM   4182 O  OE2 . GLU A 1 571 ? -21.896 -72.513 -27.362 1.00 99.43  ? 834  GLU A OE2 1 
ATOM   4183 N  N   . GLU A 1 572 ? -20.518 -67.353 -31.935 0.50 42.88  ? 835  GLU A N   1 
ATOM   4184 C  CA  . GLU A 1 572 ? -19.899 -66.786 -33.166 0.50 45.21  ? 835  GLU A CA  1 
ATOM   4185 C  C   . GLU A 1 572 ? -19.072 -65.540 -32.813 0.50 43.80  ? 835  GLU A C   1 
ATOM   4186 O  O   . GLU A 1 572 ? -18.377 -65.023 -33.720 0.50 45.32  ? 835  GLU A O   1 
ATOM   4187 C  CB  . GLU A 1 572 ? -20.969 -66.433 -34.201 0.50 47.37  ? 835  GLU A CB  1 
ATOM   4188 C  CG  . GLU A 1 572 ? -22.054 -67.488 -34.327 0.50 51.61  ? 835  GLU A CG  1 
ATOM   4189 C  CD  . GLU A 1 572 ? -23.184 -67.153 -35.288 0.50 54.03  ? 835  GLU A CD  1 
ATOM   4190 O  OE1 . GLU A 1 572 ? -23.074 -66.149 -36.021 0.50 54.50  ? 835  GLU A OE1 1 
ATOM   4191 O  OE2 . GLU A 1 572 ? -24.186 -67.896 -35.290 0.50 59.49  ? 835  GLU A OE2 1 
ATOM   4192 N  N   . ILE A 1 573 ? -19.170 -65.056 -31.567 1.00 39.87  ? 836  ILE A N   1 
ATOM   4193 C  CA  . ILE A 1 573 ? -18.515 -63.784 -31.126 1.00 37.97  ? 836  ILE A CA  1 
ATOM   4194 C  C   . ILE A 1 573 ? -17.228 -64.131 -30.387 1.00 32.03  ? 836  ILE A C   1 
ATOM   4195 O  O   . ILE A 1 573 ? -17.220 -64.783 -29.333 1.00 31.97  ? 836  ILE A O   1 
ATOM   4196 C  CB  . ILE A 1 573 ? -19.476 -62.947 -30.267 1.00 38.68  ? 836  ILE A CB  1 
ATOM   4197 C  CG1 . ILE A 1 573 ? -20.727 -62.522 -31.043 1.00 37.17  ? 836  ILE A CG1 1 
ATOM   4198 C  CG2 . ILE A 1 573 ? -18.758 -61.751 -29.682 1.00 40.22  ? 836  ILE A CG2 1 
ATOM   4199 C  CD1 . ILE A 1 573 ? -21.823 -61.973 -30.148 1.00 36.28  ? 836  ILE A CD1 1 
ATOM   4200 N  N   . PRO A 1 574 ? -16.086 -63.685 -30.922 1.00 29.73  ? 837  PRO A N   1 
ATOM   4201 C  CA  . PRO A 1 574 ? -14.788 -64.112 -30.409 1.00 30.22  ? 837  PRO A CA  1 
ATOM   4202 C  C   . PRO A 1 574 ? -14.321 -63.409 -29.130 1.00 28.58  ? 837  PRO A C   1 
ATOM   4203 O  O   . PRO A 1 574 ? -14.842 -62.394 -28.770 1.00 31.65  ? 837  PRO A O   1 
ATOM   4204 C  CB  . PRO A 1 574 ? -13.856 -63.728 -31.555 1.00 30.15  ? 837  PRO A CB  1 
ATOM   4205 C  CG  . PRO A 1 574 ? -14.489 -62.472 -32.117 1.00 31.10  ? 837  PRO A CG  1 
ATOM   4206 C  CD  . PRO A 1 574 ? -15.979 -62.701 -32.006 1.00 31.50  ? 837  PRO A CD  1 
ATOM   4207 N  N   . TYR A 1 575 ? -13.321 -64.004 -28.499 1.00 32.48  ? 838  TYR A N   1 
ATOM   4208 C  CA  . TYR A 1 575 ? -12.528 -63.441 -27.390 1.00 32.69  ? 838  TYR A CA  1 
ATOM   4209 C  C   . TYR A 1 575 ? -11.134 -63.064 -27.903 1.00 33.50  ? 838  TYR A C   1 
ATOM   4210 O  O   . TYR A 1 575 ? -10.729 -63.526 -29.013 1.00 31.38  ? 838  TYR A O   1 
ATOM   4211 C  CB  . TYR A 1 575 ? -12.313 -64.501 -26.324 1.00 34.23  ? 838  TYR A CB  1 
ATOM   4212 C  CG  . TYR A 1 575 ? -13.531 -65.083 -25.672 1.00 34.94  ? 838  TYR A CG  1 
ATOM   4213 C  CD1 . TYR A 1 575 ? -14.127 -64.457 -24.593 1.00 37.16  ? 838  TYR A CD1 1 
ATOM   4214 C  CD2 . TYR A 1 575 ? -14.038 -66.295 -26.080 1.00 34.81  ? 838  TYR A CD2 1 
ATOM   4215 C  CE1 . TYR A 1 575 ? -15.229 -64.996 -23.962 1.00 37.17  ? 838  TYR A CE1 1 
ATOM   4216 C  CE2 . TYR A 1 575 ? -15.117 -66.868 -25.436 1.00 40.36  ? 838  TYR A CE2 1 
ATOM   4217 C  CZ  . TYR A 1 575 ? -15.723 -66.217 -24.380 1.00 39.35  ? 838  TYR A CZ  1 
ATOM   4218 O  OH  . TYR A 1 575 ? -16.805 -66.776 -23.776 1.00 41.88  ? 838  TYR A OH  1 
ATOM   4219 N  N   . LEU A 1 576 ? -10.415 -62.237 -27.133 0.50 31.48  ? 839  LEU A N   1 
ATOM   4220 C  CA  . LEU A 1 576 ? -8.956  -62.016 -27.291 0.50 30.95  ? 839  LEU A CA  1 
ATOM   4221 C  C   . LEU A 1 576 ? -8.260  -63.369 -27.150 0.50 30.75  ? 839  LEU A C   1 
ATOM   4222 O  O   . LEU A 1 576 ? -8.890  -64.287 -26.591 0.50 33.19  ? 839  LEU A O   1 
ATOM   4223 C  CB  . LEU A 1 576 ? -8.450  -61.063 -26.204 0.50 30.54  ? 839  LEU A CB  1 
ATOM   4224 C  CG  . LEU A 1 576 ? -9.125  -59.697 -26.120 0.50 30.41  ? 839  LEU A CG  1 
ATOM   4225 C  CD1 . LEU A 1 576 ? -8.581  -58.925 -24.931 0.50 30.22  ? 839  LEU A CD1 1 
ATOM   4226 C  CD2 . LEU A 1 576 ? -8.939  -58.902 -27.406 0.50 30.62  ? 839  LEU A CD2 1 
ATOM   4227 N  N   . GLY A 1 577 ? -7.005  -63.472 -27.592 1.00 29.98  ? 840  GLY A N   1 
ATOM   4228 C  CA  . GLY A 1 577 ? -6.164  -64.634 -27.278 1.00 27.31  ? 840  GLY A CA  1 
ATOM   4229 C  C   . GLY A 1 577 ? -6.043  -64.772 -25.745 1.00 28.71  ? 840  GLY A C   1 
ATOM   4230 O  O   . GLY A 1 577 ? -6.134  -63.736 -24.992 1.00 24.48  ? 840  GLY A O   1 
ATOM   4231 N  N   . LYS A 1 578 ? -5.893  -65.991 -25.250 1.00 26.91  ? 841  LYS A N   1 
ATOM   4232 C  CA  . LYS A 1 578 ? -5.865  -66.240 -23.799 1.00 31.66  ? 841  LYS A CA  1 
ATOM   4233 C  C   . LYS A 1 578 ? -4.712  -65.460 -23.180 1.00 29.06  ? 841  LYS A C   1 
ATOM   4234 O  O   . LYS A 1 578 ? -4.922  -64.867 -22.134 1.00 33.67  ? 841  LYS A O   1 
ATOM   4235 C  CB  . LYS A 1 578 ? -5.760  -67.736 -23.538 1.00 38.41  ? 841  LYS A CB  1 
ATOM   4236 C  CG  . LYS A 1 578 ? -5.678  -68.076 -22.055 1.00 48.39  ? 841  LYS A CG  1 
ATOM   4237 C  CD  . LYS A 1 578 ? -5.676  -69.572 -21.756 1.00 52.97  ? 841  LYS A CD  1 
ATOM   4238 C  CE  . LYS A 1 578 ? -4.604  -70.006 -20.780 1.00 55.32  ? 841  LYS A CE  1 
ATOM   4239 N  NZ  . LYS A 1 578 ? -5.019  -71.204 -20.018 1.00 58.86  ? 841  LYS A NZ  1 
ATOM   4240 N  N   . ARG A 1 579 ? -3.560  -65.400 -23.833 1.00 28.17  ? 842  ARG A N   1 
ATOM   4241 C  CA  . ARG A 1 579 ? -2.366  -64.664 -23.329 1.00 28.63  ? 842  ARG A CA  1 
ATOM   4242 C  C   . ARG A 1 579 ? -2.672  -63.159 -23.316 1.00 29.77  ? 842  ARG A C   1 
ATOM   4243 O  O   . ARG A 1 579 ? -2.386  -62.475 -22.262 1.00 30.83  ? 842  ARG A O   1 
ATOM   4244 C  CB  . ARG A 1 579 ? -1.075  -65.050 -24.074 1.00 27.70  ? 842  ARG A CB  1 
ATOM   4245 C  CG  . ARG A 1 579 ? 0.197   -64.547 -23.398 1.00 30.81  ? 842  ARG A CG  1 
ATOM   4246 C  CD  . ARG A 1 579 ? 1.533   -64.936 -24.048 1.00 34.25  ? 842  ARG A CD  1 
ATOM   4247 N  NE  . ARG A 1 579 ? 1.489   -66.368 -24.159 1.00 36.20  ? 842  ARG A NE  1 
ATOM   4248 C  CZ  . ARG A 1 579 ? 1.643   -67.183 -23.140 1.00 38.03  ? 842  ARG A CZ  1 
ATOM   4249 N  NH1 . ARG A 1 579 ? 1.395   -68.466 -23.313 1.00 41.16  ? 842  ARG A NH1 1 
ATOM   4250 N  NH2 . ARG A 1 579 ? 2.023   -66.711 -21.964 1.00 40.24  ? 842  ARG A NH2 1 
ATOM   4251 N  N   . GLU A 1 580 ? -3.238  -62.632 -24.408 0.50 29.49  ? 843  GLU A N   1 
ATOM   4252 C  CA  . GLU A 1 580 ? -3.695  -61.214 -24.482 0.50 30.10  ? 843  GLU A CA  1 
ATOM   4253 C  C   . GLU A 1 580 ? -4.673  -60.940 -23.329 0.50 27.11  ? 843  GLU A C   1 
ATOM   4254 O  O   . GLU A 1 580 ? -4.540  -59.897 -22.695 0.50 26.43  ? 843  GLU A O   1 
ATOM   4255 C  CB  . GLU A 1 580 ? -4.353  -60.908 -25.829 0.50 31.42  ? 843  GLU A CB  1 
ATOM   4256 C  CG  . GLU A 1 580 ? -3.424  -61.072 -27.013 0.50 33.34  ? 843  GLU A CG  1 
ATOM   4257 C  CD  . GLU A 1 580 ? -4.000  -60.571 -28.330 0.50 34.95  ? 843  GLU A CD  1 
ATOM   4258 O  OE1 . GLU A 1 580 ? -5.223  -60.729 -28.532 0.50 38.04  ? 843  GLU A OE1 1 
ATOM   4259 O  OE2 . GLU A 1 580 ? -3.227  -60.020 -29.149 0.50 33.29  ? 843  GLU A OE2 1 
ATOM   4260 N  N   . ASP A 1 581 ? -5.605  -61.860 -23.065 1.00 26.28  ? 844  ASP A N   1 
ATOM   4261 C  CA  . ASP A 1 581 ? -6.615  -61.704 -21.997 1.00 26.64  ? 844  ASP A CA  1 
ATOM   4262 C  C   . ASP A 1 581 ? -5.924  -61.616 -20.649 1.00 28.14  ? 844  ASP A C   1 
ATOM   4263 O  O   . ASP A 1 581 ? -6.300  -60.711 -19.858 1.00 28.38  ? 844  ASP A O   1 
ATOM   4264 C  CB  . ASP A 1 581 ? -7.645  -62.823 -22.026 1.00 27.75  ? 844  ASP A CB  1 
ATOM   4265 C  CG  . ASP A 1 581 ? -9.052  -62.435 -21.576 1.00 27.28  ? 844  ASP A CG  1 
ATOM   4266 O  OD1 . ASP A 1 581 ? -9.233  -61.368 -20.913 1.00 25.47  ? 844  ASP A OD1 1 
ATOM   4267 O  OD2 . ASP A 1 581 ? -9.959  -63.228 -21.881 1.00 28.00  ? 844  ASP A OD2 1 
ATOM   4268 N  N   . GLN A 1 582 ? -4.898  -62.427 -20.427 1.00 28.51  ? 845  GLN A N   1 
ATOM   4269 C  CA  . GLN A 1 582 ? -4.135  -62.411 -19.146 1.00 31.59  ? 845  GLN A CA  1 
ATOM   4270 C  C   . GLN A 1 582 ? -3.338  -61.102 -19.018 1.00 28.80  ? 845  GLN A C   1 
ATOM   4271 O  O   . GLN A 1 582 ? -3.370  -60.459 -17.921 1.00 23.98  ? 845  GLN A O   1 
ATOM   4272 C  CB  . GLN A 1 582 ? -3.227  -63.648 -19.054 1.00 35.61  ? 845  GLN A CB  1 
ATOM   4273 C  CG  . GLN A 1 582 ? -3.978  -64.979 -18.956 1.00 37.53  ? 845  GLN A CG  1 
ATOM   4274 C  CD  . GLN A 1 582 ? -3.016  -66.157 -18.977 1.00 42.99  ? 845  GLN A CD  1 
ATOM   4275 O  OE1 . GLN A 1 582 ? -2.003  -66.108 -19.643 1.00 40.74  ? 845  GLN A OE1 1 
ATOM   4276 N  NE2 . GLN A 1 582 ? -3.296  -67.223 -18.237 1.00 40.88  ? 845  GLN A NE2 1 
ATOM   4277 N  N   . TRP A 1 583 ? -2.690  -60.681 -20.103 1.00 25.25  ? 846  TRP A N   1 
ATOM   4278 C  CA  . TRP A 1 583 ? -1.939  -59.401 -20.165 1.00 25.49  ? 846  TRP A CA  1 
ATOM   4279 C  C   . TRP A 1 583 ? -2.842  -58.242 -19.736 1.00 30.37  ? 846  TRP A C   1 
ATOM   4280 O  O   . TRP A 1 583 ? -2.334  -57.293 -19.058 1.00 25.32  ? 846  TRP A O   1 
ATOM   4281 C  CB  . TRP A 1 583 ? -1.378  -59.153 -21.568 1.00 28.05  ? 846  TRP A CB  1 
ATOM   4282 C  CG  . TRP A 1 583 ? -0.199  -60.022 -21.900 1.00 29.07  ? 846  TRP A CG  1 
ATOM   4283 C  CD1 . TRP A 1 583 ? 0.572   -60.741 -21.037 1.00 28.92  ? 846  TRP A CD1 1 
ATOM   4284 C  CD2 . TRP A 1 583 ? 0.315   -60.287 -23.209 1.00 27.89  ? 846  TRP A CD2 1 
ATOM   4285 N  NE1 . TRP A 1 583 ? 1.554   -61.411 -21.727 1.00 32.96  ? 846  TRP A NE1 1 
ATOM   4286 C  CE2 . TRP A 1 583 ? 1.435   -61.127 -23.058 1.00 31.92  ? 846  TRP A CE2 1 
ATOM   4287 C  CE3 . TRP A 1 583 ? -0.024  -59.854 -24.487 1.00 30.97  ? 846  TRP A CE3 1 
ATOM   4288 C  CZ2 . TRP A 1 583 ? 2.175   -61.581 -24.155 1.00 35.01  ? 846  TRP A CZ2 1 
ATOM   4289 C  CZ3 . TRP A 1 583 ? 0.710   -60.280 -25.570 1.00 32.75  ? 846  TRP A CZ3 1 
ATOM   4290 C  CH2 . TRP A 1 583 ? 1.802   -61.132 -25.404 1.00 34.69  ? 846  TRP A CH2 1 
ATOM   4291 N  N   . CYS A 1 584 ? -4.134  -58.285 -20.104 1.00 27.75  ? 847  CYS A N   1 
ATOM   4292 C  CA  . CYS A 1 584 ? -5.063  -57.191 -19.747 1.00 27.15  ? 847  CYS A CA  1 
ATOM   4293 C  C   . CYS A 1 584 ? -5.814  -57.550 -18.472 1.00 26.91  ? 847  CYS A C   1 
ATOM   4294 O  O   . CYS A 1 584 ? -6.885  -56.982 -18.249 1.00 27.72  ? 847  CYS A O   1 
ATOM   4295 C  CB  . CYS A 1 584 ? -5.967  -56.821 -20.915 1.00 27.28  ? 847  CYS A CB  1 
ATOM   4296 S  SG  . CYS A 1 584 ? -4.999  -56.096 -22.247 1.00 29.96  ? 847  CYS A SG  1 
ATOM   4297 N  N   . GLY A 1 585 ? -5.280  -58.459 -17.657 1.00 29.04  ? 848  GLY A N   1 
ATOM   4298 C  CA  . GLY A 1 585 ? -5.737  -58.607 -16.259 1.00 27.49  ? 848  GLY A CA  1 
ATOM   4299 C  C   . GLY A 1 585 ? -6.653  -59.782 -16.003 1.00 27.05  ? 848  GLY A C   1 
ATOM   4300 O  O   . GLY A 1 585 ? -7.056  -59.923 -14.821 1.00 30.46  ? 848  GLY A O   1 
ATOM   4301 N  N   . SER A 1 586 ? -6.953  -60.629 -17.002 1.00 24.82  ? 849  SER A N   1 
ATOM   4302 C  CA  . SER A 1 586 ? -7.765  -61.859 -16.800 1.00 26.12  ? 849  SER A CA  1 
ATOM   4303 C  C   . SER A 1 586 ? -7.174  -62.708 -15.661 1.00 26.90  ? 849  SER A C   1 
ATOM   4304 O  O   . SER A 1 586 ? -5.948  -62.853 -15.617 1.00 24.51  ? 849  SER A O   1 
ATOM   4305 C  CB  . SER A 1 586 ? -7.842  -62.660 -18.071 1.00 27.37  ? 849  SER A CB  1 
ATOM   4306 O  OG  . SER A 1 586 ? -8.765  -63.732 -17.933 1.00 26.87  ? 849  SER A OG  1 
ATOM   4307 N  N   . LEU A 1 587 ? -8.021  -63.344 -14.857 1.00 26.75  ? 850  LEU A N   1 
ATOM   4308 C  CA  . LEU A 1 587 ? -7.620  -64.390 -13.869 1.00 27.57  ? 850  LEU A CA  1 
ATOM   4309 C  C   . LEU A 1 587 ? -7.745  -65.782 -14.483 1.00 28.68  ? 850  LEU A C   1 
ATOM   4310 O  O   . LEU A 1 587 ? -7.596  -66.737 -13.724 1.00 29.30  ? 850  LEU A O   1 
ATOM   4311 C  CB  . LEU A 1 587 ? -8.525  -64.322 -12.633 1.00 26.58  ? 850  LEU A CB  1 
ATOM   4312 C  CG  . LEU A 1 587 ? -8.549  -62.991 -11.896 1.00 28.68  ? 850  LEU A CG  1 
ATOM   4313 C  CD1 . LEU A 1 587 ? -9.216  -63.161 -10.540 1.00 29.05  ? 850  LEU A CD1 1 
ATOM   4314 C  CD2 . LEU A 1 587 ? -7.140  -62.430 -11.716 1.00 30.87  ? 850  LEU A CD2 1 
ATOM   4315 N  N   . ILE A 1 588 ? -8.012  -65.905 -15.791 1.00 28.96  ? 851  ILE A N   1 
ATOM   4316 C  CA  . ILE A 1 588 ? -8.046  -67.226 -16.476 1.00 31.62  ? 851  ILE A CA  1 
ATOM   4317 C  C   . ILE A 1 588 ? -6.718  -67.940 -16.171 1.00 32.77  ? 851  ILE A C   1 
ATOM   4318 O  O   . ILE A 1 588 ? -5.634  -67.328 -16.297 1.00 31.42  ? 851  ILE A O   1 
ATOM   4319 C  CB  . ILE A 1 588 ? -8.362  -67.058 -17.984 1.00 36.79  ? 851  ILE A CB  1 
ATOM   4320 C  CG1 . ILE A 1 588 ? -8.766  -68.360 -18.657 1.00 41.98  ? 851  ILE A CG1 1 
ATOM   4321 C  CG2 . ILE A 1 588 ? -7.221  -66.414 -18.760 1.00 35.80  ? 851  ILE A CG2 1 
ATOM   4322 C  CD1 . ILE A 1 588 ? -10.070 -68.950 -18.178 1.00 50.83  ? 851  ILE A CD1 1 
ATOM   4323 N  N   . GLY A 1 589 ? -6.782  -69.192 -15.733 1.00 35.65  ? 852  GLY A N   1 
ATOM   4324 C  CA  . GLY A 1 589 ? -5.580  -69.957 -15.364 1.00 37.87  ? 852  GLY A CA  1 
ATOM   4325 C  C   . GLY A 1 589 ? -5.410  -70.068 -13.865 1.00 36.85  ? 852  GLY A C   1 
ATOM   4326 O  O   . GLY A 1 589 ? -4.764  -70.977 -13.468 1.00 39.89  ? 852  GLY A O   1 
ATOM   4327 N  N   . LEU A 1 590 ? -5.999  -69.199 -13.053 1.00 35.61  ? 853  LEU A N   1 
ATOM   4328 C  CA  . LEU A 1 590 ? -5.926  -69.348 -11.578 1.00 36.72  ? 853  LEU A CA  1 
ATOM   4329 C  C   . LEU A 1 590 ? -6.976  -70.350 -11.085 1.00 39.02  ? 853  LEU A C   1 
ATOM   4330 O  O   . LEU A 1 590 ? -8.092  -70.479 -11.686 1.00 39.11  ? 853  LEU A O   1 
ATOM   4331 C  CB  . LEU A 1 590 ? -6.129  -68.005 -10.871 1.00 34.82  ? 853  LEU A CB  1 
ATOM   4332 C  CG  . LEU A 1 590 ? -5.150  -66.887 -11.226 1.00 37.84  ? 853  LEU A CG  1 
ATOM   4333 C  CD1 . LEU A 1 590 ? -5.436  -65.659 -10.371 1.00 41.04  ? 853  LEU A CD1 1 
ATOM   4334 C  CD2 . LEU A 1 590 ? -3.692  -67.318 -11.069 1.00 36.88  ? 853  LEU A CD2 1 
ATOM   4335 N  N   . THR A 1 591 ? -6.618  -71.008 -9.987  1.00 40.65  ? 854  THR A N   1 
ATOM   4336 C  CA  . THR A 1 591 ? -7.462  -71.949 -9.213  1.00 38.93  ? 854  THR A CA  1 
ATOM   4337 C  C   . THR A 1 591 ? -8.730  -71.225 -8.762  1.00 33.45  ? 854  THR A C   1 
ATOM   4338 O  O   . THR A 1 591 ? -9.818  -71.735 -9.037  1.00 37.16  ? 854  THR A O   1 
ATOM   4339 C  CB  . THR A 1 591 ? -6.637  -72.517 -8.051  1.00 39.84  ? 854  THR A CB  1 
ATOM   4340 O  OG1 . THR A 1 591 ? -5.711  -73.353 -8.729  1.00 45.38  ? 854  THR A OG1 1 
ATOM   4341 C  CG2 . THR A 1 591 ? -7.420  -73.322 -7.037  1.00 40.75  ? 854  THR A CG2 1 
ATOM   4342 N  N   . SER A 1 592 ? -8.600  -70.057 -8.145  1.00 34.02  ? 855  SER A N   1 
ATOM   4343 C  CA  . SER A 1 592 ? -9.760  -69.256 -7.655  1.00 35.16  ? 855  SER A CA  1 
ATOM   4344 C  C   . SER A 1 592 ? -10.817 -69.048 -8.762  1.00 35.38  ? 855  SER A C   1 
ATOM   4345 O  O   . SER A 1 592 ? -12.028 -69.231 -8.496  1.00 39.63  ? 855  SER A O   1 
ATOM   4346 C  CB  . SER A 1 592 ? -9.321  -67.965 -7.040  1.00 31.88  ? 855  SER A CB  1 
ATOM   4347 O  OG  . SER A 1 592 ? -8.640  -67.127 -7.971  1.00 36.43  ? 855  SER A OG  1 
ATOM   4348 N  N   . ARG A 1 593 ? -10.372 -68.685 -9.968  0.50 34.18  ? 856  ARG A N   1 
ATOM   4349 C  CA  . ARG A 1 593 ? -11.251 -68.354 -11.121 0.50 34.45  ? 856  ARG A CA  1 
ATOM   4350 C  C   . ARG A 1 593 ? -11.920 -69.635 -11.638 0.50 35.65  ? 856  ARG A C   1 
ATOM   4351 O  O   . ARG A 1 593 ? -13.127 -69.583 -11.948 0.50 36.18  ? 856  ARG A O   1 
ATOM   4352 C  CB  . ARG A 1 593 ? -10.437 -67.651 -12.211 0.50 34.10  ? 856  ARG A CB  1 
ATOM   4353 C  CG  . ARG A 1 593 ? -11.276 -67.037 -13.322 0.50 34.95  ? 856  ARG A CG  1 
ATOM   4354 C  CD  . ARG A 1 593 ? -11.577 -67.997 -14.457 0.50 34.59  ? 856  ARG A CD  1 
ATOM   4355 N  NE  . ARG A 1 593 ? -12.073 -67.248 -15.601 0.50 36.33  ? 856  ARG A NE  1 
ATOM   4356 C  CZ  . ARG A 1 593 ? -12.875 -67.735 -16.541 0.50 35.62  ? 856  ARG A CZ  1 
ATOM   4357 N  NH1 . ARG A 1 593 ? -13.271 -68.993 -16.486 0.50 35.64  ? 856  ARG A NH1 1 
ATOM   4358 N  NH2 . ARG A 1 593 ? -13.274 -66.960 -17.533 0.50 34.76  ? 856  ARG A NH2 1 
ATOM   4359 N  N   . ALA A 1 594 ? -11.166 -70.735 -11.730 1.00 33.98  ? 857  ALA A N   1 
ATOM   4360 C  CA  . ALA A 1 594 ? -11.692 -72.063 -12.131 1.00 36.64  ? 857  ALA A CA  1 
ATOM   4361 C  C   . ALA A 1 594 ? -12.837 -72.516 -11.207 1.00 35.98  ? 857  ALA A C   1 
ATOM   4362 O  O   . ALA A 1 594 ? -13.843 -73.013 -11.709 1.00 29.12  ? 857  ALA A O   1 
ATOM   4363 C  CB  . ALA A 1 594 ? -10.572 -73.066 -12.091 1.00 38.11  ? 857  ALA A CB  1 
ATOM   4364 N  N   . THR A 1 595 ? -12.716 -72.309 -9.902  1.00 34.41  ? 858  THR A N   1 
ATOM   4365 C  CA  . THR A 1 595 ? -13.760 -72.723 -8.945  1.00 37.22  ? 858  THR A CA  1 
ATOM   4366 C  C   . THR A 1 595 ? -14.999 -71.857 -9.120  1.00 37.09  ? 858  THR A C   1 
ATOM   4367 O  O   . THR A 1 595 ? -16.140 -72.394 -9.099  1.00 37.07  ? 858  THR A O   1 
ATOM   4368 C  CB  . THR A 1 595 ? -13.294 -72.586 -7.502  1.00 39.31  ? 858  THR A CB  1 
ATOM   4369 O  OG1 . THR A 1 595 ? -12.071 -73.305 -7.430  1.00 47.31  ? 858  THR A OG1 1 
ATOM   4370 C  CG2 . THR A 1 595 ? -14.291 -73.169 -6.534  1.00 40.05  ? 858  THR A CG2 1 
ATOM   4371 N  N   . TRP A 1 596 ? -14.768 -70.553 -9.201  1.00 35.26  ? 859  TRP A N   1 
ATOM   4372 C  CA  . TRP A 1 596 ? -15.824 -69.545 -9.458  1.00 32.02  ? 859  TRP A CA  1 
ATOM   4373 C  C   . TRP A 1 596 ? -16.604 -69.969 -10.700 1.00 30.29  ? 859  TRP A C   1 
ATOM   4374 O  O   . TRP A 1 596 ? -17.819 -70.085 -10.579 1.00 31.68  ? 859  TRP A O   1 
ATOM   4375 C  CB  . TRP A 1 596 ? -15.209 -68.145 -9.566  1.00 31.94  ? 859  TRP A CB  1 
ATOM   4376 C  CG  . TRP A 1 596 ? -16.054 -67.040 -10.127 1.00 31.53  ? 859  TRP A CG  1 
ATOM   4377 C  CD1 . TRP A 1 596 ? -17.065 -66.393 -9.490  1.00 29.60  ? 859  TRP A CD1 1 
ATOM   4378 C  CD2 . TRP A 1 596 ? -15.903 -66.384 -11.396 1.00 30.76  ? 859  TRP A CD2 1 
ATOM   4379 N  NE1 . TRP A 1 596 ? -17.557 -65.391 -10.273 1.00 29.94  ? 859  TRP A NE1 1 
ATOM   4380 C  CE2 . TRP A 1 596 ? -16.862 -65.347 -11.443 1.00 30.22  ? 859  TRP A CE2 1 
ATOM   4381 C  CE3 . TRP A 1 596 ? -15.045 -66.555 -12.487 1.00 32.15  ? 859  TRP A CE3 1 
ATOM   4382 C  CZ2 . TRP A 1 596 ? -16.997 -64.478 -12.527 1.00 30.69  ? 859  TRP A CZ2 1 
ATOM   4383 C  CZ3 . TRP A 1 596 ? -15.152 -65.681 -13.557 1.00 36.45  ? 859  TRP A CZ3 1 
ATOM   4384 C  CH2 . TRP A 1 596 ? -16.134 -64.672 -13.583 1.00 37.56  ? 859  TRP A CH2 1 
ATOM   4385 N  N   . ALA A 1 597 ? -15.943 -70.165 -11.842 1.00 33.57  ? 860  ALA A N   1 
ATOM   4386 C  CA  . ALA A 1 597 ? -16.603 -70.504 -13.134 1.00 37.95  ? 860  ALA A CA  1 
ATOM   4387 C  C   . ALA A 1 597 ? -17.407 -71.798 -12.977 1.00 38.92  ? 860  ALA A C   1 
ATOM   4388 O  O   . ALA A 1 597 ? -18.591 -71.822 -13.307 1.00 40.26  ? 860  ALA A O   1 
ATOM   4389 C  CB  . ALA A 1 597 ? -15.593 -70.654 -14.244 1.00 33.36  ? 860  ALA A CB  1 
ATOM   4390 N  N   . LYS A 1 598 ? -16.764 -72.810 -12.412 1.00 44.66  ? 861  LYS A N   1 
ATOM   4391 C  CA  . LYS A 1 598 ? -17.303 -74.174 -12.233 1.00 44.85  ? 861  LYS A CA  1 
ATOM   4392 C  C   . LYS A 1 598 ? -18.575 -74.096 -11.405 1.00 40.43  ? 861  LYS A C   1 
ATOM   4393 O  O   . LYS A 1 598 ? -19.534 -74.755 -11.786 1.00 34.28  ? 861  LYS A O   1 
ATOM   4394 C  CB  . LYS A 1 598 ? -16.254 -75.027 -11.520 1.00 60.02  ? 861  LYS A CB  1 
ATOM   4395 C  CG  . LYS A 1 598 ? -16.437 -76.534 -11.582 1.00 72.08  ? 861  LYS A CG  1 
ATOM   4396 C  CD  . LYS A 1 598 ? -15.451 -77.272 -10.679 1.00 88.86  ? 861  LYS A CD  1 
ATOM   4397 C  CE  . LYS A 1 598 ? -14.883 -78.528 -11.314 1.00 100.36 ? 861  LYS A CE  1 
ATOM   4398 N  NZ  . LYS A 1 598 ? -15.948 -79.410 -11.861 1.00 96.78  ? 861  LYS A NZ  1 
ATOM   4399 N  N   . ASN A 1 599 ? -18.568 -73.322 -10.323 1.00 36.02  ? 862  ASN A N   1 
ATOM   4400 C  CA  . ASN A 1 599 ? -19.672 -73.295 -9.324  1.00 40.70  ? 862  ASN A CA  1 
ATOM   4401 C  C   . ASN A 1 599 ? -20.548 -72.057 -9.485  1.00 36.82  ? 862  ASN A C   1 
ATOM   4402 O  O   . ASN A 1 599 ? -21.145 -71.611 -8.480  1.00 33.63  ? 862  ASN A O   1 
ATOM   4403 C  CB  . ASN A 1 599 ? -19.098 -73.340 -7.906  1.00 44.28  ? 862  ASN A CB  1 
ATOM   4404 C  CG  . ASN A 1 599 ? -18.323 -74.620 -7.704  1.00 44.65  ? 862  ASN A CG  1 
ATOM   4405 O  OD1 . ASN A 1 599 ? -18.872 -75.689 -7.887  1.00 48.10  ? 862  ASN A OD1 1 
ATOM   4406 N  ND2 . ASN A 1 599 ? -17.043 -74.519 -7.424  1.00 49.02  ? 862  ASN A ND2 1 
ATOM   4407 N  N   . ILE A 1 600 ? -20.616 -71.494 -10.684 1.00 34.40  ? 863  ILE A N   1 
ATOM   4408 C  CA  . ILE A 1 600 ? -21.250 -70.153 -10.874 1.00 33.67  ? 863  ILE A CA  1 
ATOM   4409 C  C   . ILE A 1 600 ? -22.756 -70.196 -10.533 1.00 33.90  ? 863  ILE A C   1 
ATOM   4410 O  O   . ILE A 1 600 ? -23.266 -69.222 -9.929  1.00 33.27  ? 863  ILE A O   1 
ATOM   4411 C  CB  . ILE A 1 600 ? -20.938 -69.580 -12.270 1.00 31.02  ? 863  ILE A CB  1 
ATOM   4412 C  CG1 . ILE A 1 600 ? -21.261 -68.089 -12.340 1.00 33.48  ? 863  ILE A CG1 1 
ATOM   4413 C  CG2 . ILE A 1 600 ? -21.614 -70.363 -13.379 1.00 32.13  ? 863  ILE A CG2 1 
ATOM   4414 C  CD1 . ILE A 1 600 ? -20.465 -67.211 -11.381 1.00 33.32  ? 863  ILE A CD1 1 
ATOM   4415 N  N   A GLN A 1 601 ? -23.437 -71.291 -10.886 0.25 33.40  ? 864  GLN A N   1 
ATOM   4416 N  N   B GLN A 1 601 ? -23.442 -71.290 -10.878 0.25 33.43  ? 864  GLN A N   1 
ATOM   4417 C  CA  A GLN A 1 601 ? -24.902 -71.465 -10.665 0.25 34.13  ? 864  GLN A CA  1 
ATOM   4418 C  CA  B GLN A 1 601 ? -24.910 -71.439 -10.664 0.25 34.20  ? 864  GLN A CA  1 
ATOM   4419 C  C   A GLN A 1 601 ? -25.221 -71.349 -9.166  0.25 33.33  ? 864  GLN A C   1 
ATOM   4420 C  C   B GLN A 1 601 ? -25.228 -71.357 -9.162  0.25 33.35  ? 864  GLN A C   1 
ATOM   4421 O  O   A GLN A 1 601 ? -26.335 -70.905 -8.835  0.25 34.51  ? 864  GLN A O   1 
ATOM   4422 O  O   B GLN A 1 601 ? -26.350 -70.942 -8.824  0.25 34.49  ? 864  GLN A O   1 
ATOM   4423 C  CB  A GLN A 1 601 ? -25.390 -72.794 -11.245 0.25 33.50  ? 864  GLN A CB  1 
ATOM   4424 C  CB  B GLN A 1 601 ? -25.427 -72.735 -11.292 0.25 33.69  ? 864  GLN A CB  1 
ATOM   4425 C  CG  A GLN A 1 601 ? -25.405 -72.835 -12.769 0.25 34.26  ? 864  GLN A CG  1 
ATOM   4426 C  CG  B GLN A 1 601 ? -26.939 -72.905 -11.191 0.25 33.68  ? 864  GLN A CG  1 
ATOM   4427 C  CD  A GLN A 1 601 ? -26.307 -71.803 -13.400 0.25 33.29  ? 864  GLN A CD  1 
ATOM   4428 C  CD  B GLN A 1 601 ? -27.730 -71.781 -11.816 0.25 35.50  ? 864  GLN A CD  1 
ATOM   4429 O  OE1 A GLN A 1 601 ? -27.136 -71.187 -12.737 0.25 36.12  ? 864  GLN A OE1 1 
ATOM   4430 O  OE1 B GLN A 1 601 ? -27.615 -71.493 -13.007 0.25 36.11  ? 864  GLN A OE1 1 
ATOM   4431 N  NE2 A GLN A 1 601 ? -26.169 -71.622 -14.703 0.25 31.99  ? 864  GLN A NE2 1 
ATOM   4432 N  NE2 B GLN A 1 601 ? -28.575 -71.152 -11.012 0.25 35.27  ? 864  GLN A NE2 1 
ATOM   4433 N  N   . THR A 1 602 ? -24.274 -71.705 -8.297  1.00 31.96  ? 865  THR A N   1 
ATOM   4434 C  CA  . THR A 1 602 ? -24.438 -71.596 -6.829  1.00 34.10  ? 865  THR A CA  1 
ATOM   4435 C  C   . THR A 1 602 ? -24.339 -70.141 -6.363  1.00 35.51  ? 865  THR A C   1 
ATOM   4436 O  O   . THR A 1 602 ? -25.037 -69.771 -5.402  1.00 37.72  ? 865  THR A O   1 
ATOM   4437 C  CB  . THR A 1 602 ? -23.371 -72.432 -6.126  1.00 36.72  ? 865  THR A CB  1 
ATOM   4438 O  OG1 . THR A 1 602 ? -23.560 -73.771 -6.613  1.00 37.65  ? 865  THR A OG1 1 
ATOM   4439 C  CG2 . THR A 1 602 ? -23.454 -72.303 -4.621  1.00 36.30  ? 865  THR A CG2 1 
ATOM   4440 N  N   . ALA A 1 603 ? -23.478 -69.343 -6.992  1.00 36.93  ? 866  ALA A N   1 
ATOM   4441 C  CA  . ALA A 1 603 ? -23.393 -67.890 -6.738  1.00 33.85  ? 866  ALA A CA  1 
ATOM   4442 C  C   . ALA A 1 603 ? -24.662 -67.240 -7.259  1.00 31.22  ? 866  ALA A C   1 
ATOM   4443 O  O   . ALA A 1 603 ? -25.229 -66.396 -6.552  1.00 27.94  ? 866  ALA A O   1 
ATOM   4444 C  CB  . ALA A 1 603 ? -22.190 -67.287 -7.393  1.00 36.27  ? 866  ALA A CB  1 
ATOM   4445 N  N   . ILE A 1 604 ? -25.073 -67.627 -8.457  1.00 28.55  ? 867  ILE A N   1 
ATOM   4446 C  CA  . ILE A 1 604 ? -26.330 -67.106 -9.054  1.00 31.39  ? 867  ILE A CA  1 
ATOM   4447 C  C   . ILE A 1 604 ? -27.500 -67.390 -8.094  1.00 30.31  ? 867  ILE A C   1 
ATOM   4448 O  O   . ILE A 1 604 ? -28.229 -66.446 -7.772  1.00 30.00  ? 867  ILE A O   1 
ATOM   4449 C  CB  . ILE A 1 604 ? -26.505 -67.674 -10.466 1.00 30.57  ? 867  ILE A CB  1 
ATOM   4450 C  CG1 . ILE A 1 604 ? -25.447 -67.068 -11.390 1.00 29.93  ? 867  ILE A CG1 1 
ATOM   4451 C  CG2 . ILE A 1 604 ? -27.906 -67.411 -10.985 1.00 32.96  ? 867  ILE A CG2 1 
ATOM   4452 C  CD1 . ILE A 1 604 ? -25.423 -67.656 -12.784 1.00 32.74  ? 867  ILE A CD1 1 
ATOM   4453 N  N   . ASN A 1 605 ? -27.603 -68.608 -7.552  1.00 36.91  ? 868  ASN A N   1 
ATOM   4454 C  CA  . ASN A 1 605 ? -28.698 -69.015 -6.626  1.00 34.93  ? 868  ASN A CA  1 
ATOM   4455 C  C   . ASN A 1 605 ? -28.612 -68.224 -5.317  1.00 34.46  ? 868  ASN A C   1 
ATOM   4456 O  O   . ASN A 1 605 ? -29.676 -67.932 -4.770  1.00 33.94  ? 868  ASN A O   1 
ATOM   4457 C  CB  . ASN A 1 605 ? -28.735 -70.528 -6.377  1.00 40.04  ? 868  ASN A CB  1 
ATOM   4458 C  CG  . ASN A 1 605 ? -29.084 -71.343 -7.618  1.00 48.79  ? 868  ASN A CG  1 
ATOM   4459 O  OD1 . ASN A 1 605 ? -29.733 -70.883 -8.568  1.00 47.42  ? 868  ASN A OD1 1 
ATOM   4460 N  ND2 . ASN A 1 605 ? -28.603 -72.572 -7.652  1.00 58.10  ? 868  ASN A ND2 1 
ATOM   4461 N  N   . GLN A 1 606 ? -27.419 -67.895 -4.810  1.00 38.65  ? 869  GLN A N   1 
ATOM   4462 C  CA  . GLN A 1 606 ? -27.303 -67.128 -3.541  1.00 36.89  ? 869  GLN A CA  1 
ATOM   4463 C  C   . GLN A 1 606 ? -28.020 -65.777 -3.731  1.00 36.15  ? 869  GLN A C   1 
ATOM   4464 O  O   . GLN A 1 606 ? -28.822 -65.364 -2.854  1.00 33.57  ? 869  GLN A O   1 
ATOM   4465 C  CB  . GLN A 1 606 ? -25.849 -66.942 -3.093  1.00 43.54  ? 869  GLN A CB  1 
ATOM   4466 C  CG  . GLN A 1 606 ? -25.701 -65.988 -1.882  1.00 51.64  ? 869  GLN A CG  1 
ATOM   4467 C  CD  . GLN A 1 606 ? -24.297 -65.766 -1.344  1.00 59.42  ? 869  GLN A CD  1 
ATOM   4468 O  OE1 . GLN A 1 606 ? -23.313 -65.844 -2.081  1.00 61.19  ? 869  GLN A OE1 1 
ATOM   4469 N  NE2 . GLN A 1 606 ? -24.189 -65.481 -0.049  1.00 54.57  ? 869  GLN A NE2 1 
ATOM   4470 N  N   . VAL A 1 607 ? -27.725 -65.085 -4.828  1.00 31.61  ? 870  VAL A N   1 
ATOM   4471 C  CA  . VAL A 1 607 ? -28.280 -63.733 -5.117  1.00 31.42  ? 870  VAL A CA  1 
ATOM   4472 C  C   . VAL A 1 607 ? -29.792 -63.858 -5.393  1.00 30.35  ? 870  VAL A C   1 
ATOM   4473 O  O   . VAL A 1 607 ? -30.569 -63.023 -4.844  1.00 29.25  ? 870  VAL A O   1 
ATOM   4474 C  CB  . VAL A 1 607 ? -27.518 -63.103 -6.296  1.00 31.81  ? 870  VAL A CB  1 
ATOM   4475 C  CG1 . VAL A 1 607 ? -28.207 -61.855 -6.833  1.00 30.03  ? 870  VAL A CG1 1 
ATOM   4476 C  CG2 . VAL A 1 607 ? -26.070 -62.832 -5.898  1.00 32.82  ? 870  VAL A CG2 1 
ATOM   4477 N  N   . ARG A 1 608 ? -30.210 -64.849 -6.189  1.00 25.89  ? 871  ARG A N   1 
ATOM   4478 C  CA  . ARG A 1 608 ? -31.657 -65.082 -6.429  1.00 29.43  ? 871  ARG A CA  1 
ATOM   4479 C  C   . ARG A 1 608 ? -32.387 -65.228 -5.085  1.00 33.99  ? 871  ARG A C   1 
ATOM   4480 O  O   . ARG A 1 608 ? -33.475 -64.630 -4.943  1.00 36.89  ? 871  ARG A O   1 
ATOM   4481 C  CB  . ARG A 1 608 ? -31.895 -66.291 -7.339  1.00 29.72  ? 871  ARG A CB  1 
ATOM   4482 C  CG  . ARG A 1 608 ? -31.538 -66.040 -8.800  1.00 28.87  ? 871  ARG A CG  1 
ATOM   4483 C  CD  . ARG A 1 608 ? -31.831 -67.270 -9.622  1.00 30.75  ? 871  ARG A CD  1 
ATOM   4484 N  NE  . ARG A 1 608 ? -31.630 -67.026 -11.039 1.00 35.28  ? 871  ARG A NE  1 
ATOM   4485 C  CZ  . ARG A 1 608 ? -31.481 -67.983 -11.947 1.00 38.23  ? 871  ARG A CZ  1 
ATOM   4486 N  NH1 . ARG A 1 608 ? -31.521 -69.246 -11.569 1.00 44.74  ? 871  ARG A NH1 1 
ATOM   4487 N  NH2 . ARG A 1 608 ? -31.289 -67.693 -13.225 1.00 34.59  ? 871  ARG A NH2 1 
ATOM   4488 N  N   . SER A 1 609 ? -31.825 -65.972 -4.133  1.00 30.52  ? 872  SER A N   1 
ATOM   4489 C  CA  . SER A 1 609 ? -32.453 -66.215 -2.814  1.00 32.58  ? 872  SER A CA  1 
ATOM   4490 C  C   . SER A 1 609 ? -32.558 -64.921 -2.004  1.00 33.19  ? 872  SER A C   1 
ATOM   4491 O  O   . SER A 1 609 ? -33.454 -64.827 -1.155  1.00 33.54  ? 872  SER A O   1 
ATOM   4492 C  CB  . SER A 1 609 ? -31.676 -67.254 -2.031  1.00 34.95  ? 872  SER A CB  1 
ATOM   4493 O  OG  . SER A 1 609 ? -31.582 -68.458 -2.766  1.00 35.65  ? 872  SER A OG  1 
ATOM   4494 N  N   . LEU A 1 610 ? -31.640 -63.976 -2.185  1.00 32.41  ? 873  LEU A N   1 
ATOM   4495 C  CA  . LEU A 1 610 ? -31.653 -62.704 -1.410  1.00 34.67  ? 873  LEU A CA  1 
ATOM   4496 C  C   . LEU A 1 610 ? -32.727 -61.770 -1.990  1.00 34.39  ? 873  LEU A C   1 
ATOM   4497 O  O   . LEU A 1 610 ? -33.440 -61.097 -1.200  1.00 31.12  ? 873  LEU A O   1 
ATOM   4498 C  CB  . LEU A 1 610 ? -30.263 -62.072 -1.483  1.00 33.76  ? 873  LEU A CB  1 
ATOM   4499 C  CG  . LEU A 1 610 ? -29.184 -62.727 -0.638  1.00 32.51  ? 873  LEU A CG  1 
ATOM   4500 C  CD1 . LEU A 1 610 ? -27.830 -62.177 -1.040  1.00 32.64  ? 873  LEU A CD1 1 
ATOM   4501 C  CD2 . LEU A 1 610 ? -29.407 -62.515 0.859   1.00 35.07  ? 873  LEU A CD2 1 
ATOM   4502 N  N   . ILE A 1 611 ? -32.833 -61.747 -3.320  1.00 31.82  ? 874  ILE A N   1 
ATOM   4503 C  CA  . ILE A 1 611 ? -33.775 -60.878 -4.081  1.00 35.32  ? 874  ILE A CA  1 
ATOM   4504 C  C   . ILE A 1 611 ? -35.200 -61.433 -3.930  1.00 40.46  ? 874  ILE A C   1 
ATOM   4505 O  O   . ILE A 1 611 ? -36.098 -60.631 -3.647  1.00 40.57  ? 874  ILE A O   1 
ATOM   4506 C  CB  . ILE A 1 611 ? -33.364 -60.732 -5.554  1.00 35.27  ? 874  ILE A CB  1 
ATOM   4507 C  CG1 . ILE A 1 611 ? -32.031 -59.996 -5.679  1.00 35.68  ? 874  ILE A CG1 1 
ATOM   4508 C  CG2 . ILE A 1 611 ? -34.482 -60.050 -6.330  1.00 38.53  ? 874  ILE A CG2 1 
ATOM   4509 C  CD1 . ILE A 1 611 ? -31.484 -59.916 -7.076  1.00 38.79  ? 874  ILE A CD1 1 
ATOM   4510 N  N   . GLY A 1 612 ? -35.378 -62.754 -4.045  1.00 40.45  ? 875  GLY A N   1 
ATOM   4511 C  CA  . GLY A 1 612 ? -36.629 -63.466 -3.702  1.00 41.41  ? 875  GLY A CA  1 
ATOM   4512 C  C   . GLY A 1 612 ? -37.230 -64.192 -4.902  1.00 41.30  ? 875  GLY A C   1 
ATOM   4513 O  O   . GLY A 1 612 ? -36.517 -64.487 -5.863  1.00 38.01  ? 875  GLY A O   1 
ATOM   4514 N  N   . ASN A 1 613 ? -38.529 -64.452 -4.846  1.00 48.18  ? 876  ASN A N   1 
ATOM   4515 C  CA  . ASN A 1 613 ? -39.235 -65.386 -5.755  1.00 49.26  ? 876  ASN A CA  1 
ATOM   4516 C  C   . ASN A 1 613 ? -39.738 -64.568 -6.937  1.00 44.72  ? 876  ASN A C   1 
ATOM   4517 O  O   . ASN A 1 613 ? -40.928 -64.237 -6.978  1.00 56.26  ? 876  ASN A O   1 
ATOM   4518 C  CB  . ASN A 1 613 ? -40.357 -66.143 -5.032  1.00 52.52  ? 876  ASN A CB  1 
ATOM   4519 C  CG  . ASN A 1 613 ? -41.053 -67.161 -5.916  1.00 59.33  ? 876  ASN A CG  1 
ATOM   4520 O  OD1 . ASN A 1 613 ? -40.604 -67.438 -7.026  1.00 59.64  ? 876  ASN A OD1 1 
ATOM   4521 N  ND2 . ASN A 1 613 ? -42.146 -67.738 -5.431  1.00 61.63  ? 876  ASN A ND2 1 
ATOM   4522 N  N   . GLU A 1 614 ? -38.847 -64.280 -7.864  1.00 38.21  ? 877  GLU A N   1 
ATOM   4523 C  CA  . GLU A 1 614 ? -39.096 -63.394 -9.020  1.00 35.33  ? 877  GLU A CA  1 
ATOM   4524 C  C   . GLU A 1 614 ? -38.964 -64.280 -10.237 1.00 35.35  ? 877  GLU A C   1 
ATOM   4525 O  O   . GLU A 1 614 ? -38.674 -65.477 -10.022 1.00 34.04  ? 877  GLU A O   1 
ATOM   4526 C  CB  . GLU A 1 614 ? -38.094 -62.251 -8.986  1.00 35.70  ? 877  GLU A CB  1 
ATOM   4527 C  CG  . GLU A 1 614 ? -38.233 -61.368 -7.755  1.00 35.87  ? 877  GLU A CG  1 
ATOM   4528 C  CD  . GLU A 1 614 ? -39.363 -60.350 -7.814  1.00 38.23  ? 877  GLU A CD  1 
ATOM   4529 O  OE1 . GLU A 1 614 ? -39.949 -60.150 -8.928  1.00 31.43  ? 877  GLU A OE1 1 
ATOM   4530 O  OE2 . GLU A 1 614 ? -39.635 -59.724 -6.747  1.00 36.85  ? 877  GLU A OE2 1 
ATOM   4531 N  N   . GLU A 1 615 ? -39.171 -63.735 -11.437 1.00 38.14  ? 878  GLU A N   1 
ATOM   4532 C  CA  . GLU A 1 615 ? -38.912 -64.478 -12.699 1.00 41.94  ? 878  GLU A CA  1 
ATOM   4533 C  C   . GLU A 1 615 ? -37.490 -64.164 -13.189 1.00 40.59  ? 878  GLU A C   1 
ATOM   4534 O  O   . GLU A 1 615 ? -37.216 -62.998 -13.491 1.00 44.15  ? 878  GLU A O   1 
ATOM   4535 C  CB  . GLU A 1 615 ? -39.912 -64.107 -13.788 1.00 50.90  ? 878  GLU A CB  1 
ATOM   4536 C  CG  . GLU A 1 615 ? -39.720 -64.911 -15.062 1.00 58.45  ? 878  GLU A CG  1 
ATOM   4537 C  CD  . GLU A 1 615 ? -40.408 -64.263 -16.249 1.00 77.29  ? 878  GLU A CD  1 
ATOM   4538 O  OE1 . GLU A 1 615 ? -41.341 -63.450 -16.020 1.00 87.24  ? 878  GLU A OE1 1 
ATOM   4539 O  OE2 . GLU A 1 615 ? -40.012 -64.550 -17.397 1.00 91.90  ? 878  GLU A OE2 1 
ATOM   4540 N  N   . TYR A 1 616 ? -36.681 -65.212 -13.323 1.00 41.22  ? 879  TYR A N   1 
ATOM   4541 C  CA  . TYR A 1 616 ? -35.253 -65.247 -13.715 1.00 43.21  ? 879  TYR A CA  1 
ATOM   4542 C  C   . TYR A 1 616 ? -35.083 -66.048 -15.011 1.00 45.76  ? 879  TYR A C   1 
ATOM   4543 O  O   . TYR A 1 616 ? -35.846 -67.002 -15.239 1.00 41.12  ? 879  TYR A O   1 
ATOM   4544 C  CB  . TYR A 1 616 ? -34.457 -65.911 -12.595 1.00 39.12  ? 879  TYR A CB  1 
ATOM   4545 C  CG  . TYR A 1 616 ? -34.535 -65.192 -11.272 1.00 36.40  ? 879  TYR A CG  1 
ATOM   4546 C  CD1 . TYR A 1 616 ? -33.845 -64.014 -11.082 1.00 34.96  ? 879  TYR A CD1 1 
ATOM   4547 C  CD2 . TYR A 1 616 ? -35.270 -65.691 -10.205 1.00 34.26  ? 879  TYR A CD2 1 
ATOM   4548 C  CE1 . TYR A 1 616 ? -33.873 -63.355 -9.863  1.00 39.33  ? 879  TYR A CE1 1 
ATOM   4549 C  CE2 . TYR A 1 616 ? -35.297 -65.056 -8.974  1.00 31.45  ? 879  TYR A CE2 1 
ATOM   4550 C  CZ  . TYR A 1 616 ? -34.597 -63.877 -8.802  1.00 35.91  ? 879  TYR A CZ  1 
ATOM   4551 O  OH  . TYR A 1 616 ? -34.593 -63.183 -7.624  1.00 39.26  ? 879  TYR A OH  1 
ATOM   4552 N  N   . THR A 1 617 ? -34.081 -65.669 -15.810 1.00 44.99  ? 880  THR A N   1 
ATOM   4553 C  CA  . THR A 1 617 ? -33.572 -66.408 -16.991 1.00 42.69  ? 880  THR A CA  1 
ATOM   4554 C  C   . THR A 1 617 ? -32.152 -66.936 -16.706 1.00 44.86  ? 880  THR A C   1 
ATOM   4555 O  O   . THR A 1 617 ? -31.346 -66.203 -16.046 1.00 38.01  ? 880  THR A O   1 
ATOM   4556 C  CB  . THR A 1 617 ? -33.572 -65.462 -18.195 1.00 47.37  ? 880  THR A CB  1 
ATOM   4557 O  OG1 . THR A 1 617 ? -34.885 -64.909 -18.191 1.00 46.36  ? 880  THR A OG1 1 
ATOM   4558 C  CG2 . THR A 1 617 ? -33.242 -66.126 -19.516 1.00 42.54  ? 880  THR A CG2 1 
ATOM   4559 N  N   . ASP A 1 618 ? -31.846 -68.157 -17.167 1.00 41.14  ? 881  ASP A N   1 
ATOM   4560 C  CA  . ASP A 1 618 ? -30.469 -68.715 -17.135 1.00 45.74  ? 881  ASP A CA  1 
ATOM   4561 C  C   . ASP A 1 618 ? -29.779 -68.298 -18.446 1.00 43.35  ? 881  ASP A C   1 
ATOM   4562 O  O   . ASP A 1 618 ? -30.146 -68.828 -19.499 1.00 36.10  ? 881  ASP A O   1 
ATOM   4563 C  CB  . ASP A 1 618 ? -30.477 -70.230 -16.892 1.00 47.13  ? 881  ASP A CB  1 
ATOM   4564 C  CG  . ASP A 1 618 ? -29.108 -70.918 -16.848 1.00 55.42  ? 881  ASP A CG  1 
ATOM   4565 O  OD1 . ASP A 1 618 ? -28.083 -70.283 -16.418 1.00 45.33  ? 881  ASP A OD1 1 
ATOM   4566 O  OD2 . ASP A 1 618 ? -29.067 -72.113 -17.227 1.00 63.90  ? 881  ASP A OD2 1 
ATOM   4567 N  N   . TYR A 1 619 ? -28.817 -67.378 -18.376 1.00 39.06  ? 882  TYR A N   1 
ATOM   4568 C  CA  . TYR A 1 619 ? -28.014 -66.943 -19.541 1.00 39.15  ? 882  TYR A CA  1 
ATOM   4569 C  C   . TYR A 1 619 ? -26.721 -67.766 -19.681 1.00 39.34  ? 882  TYR A C   1 
ATOM   4570 O  O   . TYR A 1 619 ? -26.064 -67.676 -20.742 1.00 38.83  ? 882  TYR A O   1 
ATOM   4571 C  CB  . TYR A 1 619 ? -27.774 -65.446 -19.417 1.00 40.05  ? 882  TYR A CB  1 
ATOM   4572 C  CG  . TYR A 1 619 ? -29.008 -64.613 -19.644 1.00 40.53  ? 882  TYR A CG  1 
ATOM   4573 C  CD1 . TYR A 1 619 ? -29.574 -64.504 -20.906 1.00 39.90  ? 882  TYR A CD1 1 
ATOM   4574 C  CD2 . TYR A 1 619 ? -29.617 -63.937 -18.599 1.00 41.81  ? 882  TYR A CD2 1 
ATOM   4575 C  CE1 . TYR A 1 619 ? -30.704 -63.730 -21.133 1.00 39.37  ? 882  TYR A CE1 1 
ATOM   4576 C  CE2 . TYR A 1 619 ? -30.749 -63.160 -18.806 1.00 41.76  ? 882  TYR A CE2 1 
ATOM   4577 C  CZ  . TYR A 1 619 ? -31.285 -63.040 -20.080 1.00 41.88  ? 882  TYR A CZ  1 
ATOM   4578 O  OH  . TYR A 1 619 ? -32.387 -62.252 -20.275 1.00 43.46  ? 882  TYR A OH  1 
ATOM   4579 N  N   . MET A 1 620 ? -26.364 -68.595 -18.702 1.00 37.84  ? 883  MET A N   1 
ATOM   4580 C  CA  . MET A 1 620 ? -25.046 -69.289 -18.724 1.00 41.46  ? 883  MET A CA  1 
ATOM   4581 C  C   . MET A 1 620 ? -24.911 -70.271 -19.906 1.00 42.43  ? 883  MET A C   1 
ATOM   4582 O  O   . MET A 1 620 ? -23.813 -70.403 -20.445 1.00 49.98  ? 883  MET A O   1 
ATOM   4583 C  CB  . MET A 1 620 ? -24.750 -69.985 -17.392 1.00 39.70  ? 883  MET A CB  1 
ATOM   4584 C  CG  . MET A 1 620 ? -24.924 -69.081 -16.162 1.00 42.43  ? 883  MET A CG  1 
ATOM   4585 S  SD  . MET A 1 620 ? -24.124 -67.471 -16.316 1.00 42.36  ? 883  MET A SD  1 
ATOM   4586 C  CE  . MET A 1 620 ? -22.433 -68.021 -16.562 1.00 40.33  ? 883  MET A CE  1 
ATOM   4587 N  N   . PRO A 1 621 ? -25.958 -71.004 -20.360 1.00 44.39  ? 884  PRO A N   1 
ATOM   4588 C  CA  . PRO A 1 621 ? -25.855 -71.831 -21.573 1.00 43.83  ? 884  PRO A CA  1 
ATOM   4589 C  C   . PRO A 1 621 ? -25.615 -71.100 -22.907 1.00 44.44  ? 884  PRO A C   1 
ATOM   4590 O  O   . PRO A 1 621 ? -25.370 -71.784 -23.884 1.00 48.44  ? 884  PRO A O   1 
ATOM   4591 C  CB  . PRO A 1 621 ? -27.216 -72.580 -21.635 1.00 46.31  ? 884  PRO A CB  1 
ATOM   4592 C  CG  . PRO A 1 621 ? -27.774 -72.538 -20.213 1.00 42.99  ? 884  PRO A CG  1 
ATOM   4593 C  CD  . PRO A 1 621 ? -27.231 -71.241 -19.644 1.00 45.76  ? 884  PRO A CD  1 
ATOM   4594 N  N   . SER A 1 622 ? -25.650 -69.759 -22.931 1.00 45.45  ? 885  SER A N   1 
ATOM   4595 C  CA  . SER A 1 622 ? -25.121 -68.930 -24.054 1.00 49.43  ? 885  SER A CA  1 
ATOM   4596 C  C   . SER A 1 622 ? -23.600 -69.157 -24.221 1.00 50.31  ? 885  SER A C   1 
ATOM   4597 O  O   . SER A 1 622 ? -23.046 -68.790 -25.288 1.00 48.62  ? 885  SER A O   1 
ATOM   4598 C  CB  . SER A 1 622 ? -25.446 -67.457 -23.870 1.00 47.88  ? 885  SER A CB  1 
ATOM   4599 O  OG  . SER A 1 622 ? -24.690 -66.873 -22.802 1.00 45.15  ? 885  SER A OG  1 
ATOM   4600 N  N   . MET A 1 623 ? -22.967 -69.736 -23.205 1.00 46.21  ? 886  MET A N   1 
ATOM   4601 C  CA  . MET A 1 623 ? -21.522 -70.054 -23.282 1.00 58.63  ? 886  MET A CA  1 
ATOM   4602 C  C   . MET A 1 623 ? -21.375 -71.566 -23.475 1.00 61.29  ? 886  MET A C   1 
ATOM   4603 O  O   . MET A 1 623 ? -22.090 -72.307 -22.784 1.00 58.13  ? 886  MET A O   1 
ATOM   4604 C  CB  . MET A 1 623 ? -20.799 -69.605 -22.007 1.00 57.13  ? 886  MET A CB  1 
ATOM   4605 C  CG  . MET A 1 623 ? -21.130 -68.188 -21.590 1.00 61.58  ? 886  MET A CG  1 
ATOM   4606 S  SD  . MET A 1 623 ? -20.235 -67.661 -20.110 1.00 57.58  ? 886  MET A SD  1 
ATOM   4607 C  CE  . MET A 1 623 ? -18.578 -67.494 -20.767 1.00 53.79  ? 886  MET A CE  1 
ATOM   4608 N  N   . LYS A 1 624 ? -20.462 -72.000 -24.346 0.50 60.73  ? 887  LYS A N   1 
ATOM   4609 C  CA  . LYS A 1 624 ? -20.317 -73.443 -24.680 0.50 60.46  ? 887  LYS A CA  1 
ATOM   4610 C  C   . LYS A 1 624 ? -20.078 -74.305 -23.434 0.50 58.61  ? 887  LYS A C   1 
ATOM   4611 O  O   . LYS A 1 624 ? -20.742 -75.346 -23.319 0.50 56.18  ? 887  LYS A O   1 
ATOM   4612 C  CB  . LYS A 1 624 ? -19.157 -73.612 -25.663 0.50 63.45  ? 887  LYS A CB  1 
ATOM   4613 C  CG  . LYS A 1 624 ? -18.918 -75.030 -26.162 0.50 66.61  ? 887  LYS A CG  1 
ATOM   4614 C  CD  . LYS A 1 624 ? -17.719 -75.150 -27.080 0.50 68.80  ? 887  LYS A CD  1 
ATOM   4615 C  CE  . LYS A 1 624 ? -16.407 -75.325 -26.343 0.50 71.41  ? 887  LYS A CE  1 
ATOM   4616 N  NZ  . LYS A 1 624 ? -16.111 -74.185 -25.444 0.50 71.58  ? 887  LYS A NZ  1 
ATOM   4617 N  N   . ARG A 1 625 ? -19.179 -73.894 -22.539 0.50 56.56  ? 888  ARG A N   1 
ATOM   4618 C  CA  . ARG A 1 625 ? -18.818 -74.748 -21.372 0.50 55.90  ? 888  ARG A CA  1 
ATOM   4619 C  C   . ARG A 1 625 ? -20.048 -75.037 -20.504 0.50 54.22  ? 888  ARG A C   1 
ATOM   4620 O  O   . ARG A 1 625 ? -20.039 -76.063 -19.805 0.50 52.74  ? 888  ARG A O   1 
ATOM   4621 C  CB  . ARG A 1 625 ? -17.715 -74.090 -20.539 0.50 55.73  ? 888  ARG A CB  1 
ATOM   4622 C  CG  . ARG A 1 625 ? -18.161 -72.888 -19.721 0.50 56.89  ? 888  ARG A CG  1 
ATOM   4623 C  CD  . ARG A 1 625 ? -17.164 -72.622 -18.610 0.50 55.28  ? 888  ARG A CD  1 
ATOM   4624 N  NE  . ARG A 1 625 ? -17.170 -73.688 -17.620 0.50 54.98  ? 888  ARG A NE  1 
ATOM   4625 C  CZ  . ARG A 1 625 ? -16.249 -73.855 -16.678 0.50 53.72  ? 888  ARG A CZ  1 
ATOM   4626 N  NH1 . ARG A 1 625 ? -15.219 -73.031 -16.603 0.50 54.15  ? 888  ARG A NH1 1 
ATOM   4627 N  NH2 . ARG A 1 625 ? -16.351 -74.856 -15.824 0.50 54.22  ? 888  ARG A NH2 1 
ATOM   4628 N  N   . PHE A 1 626 ? -21.048 -74.156 -20.535 1.00 52.84  ? 889  PHE A N   1 
ATOM   4629 C  CA  . PHE A 1 626 ? -22.264 -74.338 -19.702 1.00 56.94  ? 889  PHE A CA  1 
ATOM   4630 C  C   . PHE A 1 626 ? -23.382 -74.961 -20.550 1.00 67.49  ? 889  PHE A C   1 
ATOM   4631 O  O   . PHE A 1 626 ? -24.347 -75.497 -19.987 1.00 71.65  ? 889  PHE A O   1 
ATOM   4632 C  CB  . PHE A 1 626 ? -22.659 -73.011 -19.050 1.00 50.26  ? 889  PHE A CB  1 
ATOM   4633 C  CG  . PHE A 1 626 ? -21.607 -72.415 -18.152 1.00 51.57  ? 889  PHE A CG  1 
ATOM   4634 C  CD1 . PHE A 1 626 ? -21.245 -73.042 -16.972 1.00 55.51  ? 889  PHE A CD1 1 
ATOM   4635 C  CD2 . PHE A 1 626 ? -20.986 -71.223 -18.481 1.00 50.62  ? 889  PHE A CD2 1 
ATOM   4636 C  CE1 . PHE A 1 626 ? -20.279 -72.494 -16.144 1.00 56.65  ? 889  PHE A CE1 1 
ATOM   4637 C  CE2 . PHE A 1 626 ? -20.022 -70.674 -17.651 1.00 56.88  ? 889  PHE A CE2 1 
ATOM   4638 C  CZ  . PHE A 1 626 ? -19.671 -71.310 -16.484 1.00 57.34  ? 889  PHE A CZ  1 
ATOM   4639 N  N   . ARG A 1 627 ? -23.242 -74.909 -21.871 1.00 75.84  ? 890  ARG A N   1 
ATOM   4640 C  CA  . ARG A 1 627 ? -24.252 -75.523 -22.768 1.00 90.97  ? 890  ARG A CA  1 
ATOM   4641 C  C   . ARG A 1 627 ? -24.111 -77.038 -22.613 1.00 95.79  ? 890  ARG A C   1 
ATOM   4642 O  O   . ARG A 1 627 ? -23.698 -77.683 -23.588 1.00 99.08  ? 890  ARG A O   1 
ATOM   4643 C  CB  . ARG A 1 627 ? -24.037 -75.020 -24.201 1.00 88.48  ? 890  ARG A CB  1 
ATOM   4644 C  CG  . ARG A 1 627 ? -25.081 -75.473 -25.207 1.00 89.65  ? 890  ARG A CG  1 
ATOM   4645 C  CD  . ARG A 1 627 ? -24.915 -74.706 -26.504 1.00 93.94  ? 890  ARG A CD  1 
ATOM   4646 N  NE  . ARG A 1 627 ? -23.518 -74.563 -26.885 1.00 92.54  ? 890  ARG A NE  1 
ATOM   4647 C  CZ  . ARG A 1 627 ? -22.841 -75.443 -27.610 1.00 95.46  ? 890  ARG A CZ  1 
ATOM   4648 N  NH1 . ARG A 1 627 ? -23.431 -76.546 -28.037 1.00 98.74  ? 890  ARG A NH1 1 
ATOM   4649 N  NH2 . ARG A 1 627 ? -21.573 -75.220 -27.905 1.00 91.42  ? 890  ARG A NH2 1 
ATOM   4650 N  N   . ARG A 1 628 ? -24.438 -77.568 -21.427 1.00 98.14  ? 891  ARG A N   1 
ATOM   4651 C  CA  . ARG A 1 628 ? -24.239 -79.014 -21.132 1.00 101.61 ? 891  ARG A CA  1 
ATOM   4652 C  C   . ARG A 1 628 ? -22.798 -79.401 -21.499 1.00 100.76 ? 891  ARG A C   1 
ATOM   4653 O  O   . ARG A 1 628 ? -22.618 -80.051 -22.547 1.00 89.40  ? 891  ARG A O   1 
ATOM   4654 C  CB  . ARG A 1 628 ? -25.290 -79.879 -21.841 1.00 108.48 ? 891  ARG A CB  1 
ATOM   4655 C  CG  . ARG A 1 628 ? -26.696 -79.729 -21.282 1.00 109.49 ? 891  ARG A CG  1 
ATOM   4656 C  CD  . ARG A 1 628 ? -26.774 -80.153 -19.830 1.00 115.99 ? 891  ARG A CD  1 
ATOM   4657 N  NE  . ARG A 1 628 ? -26.270 -81.504 -19.631 1.00 124.19 ? 891  ARG A NE  1 
ATOM   4658 C  CZ  . ARG A 1 628 ? -26.261 -82.139 -18.465 1.00 130.15 ? 891  ARG A CZ  1 
ATOM   4659 N  NH1 . ARG A 1 628 ? -26.738 -81.546 -17.384 1.00 135.63 ? 891  ARG A NH1 1 
ATOM   4660 N  NH2 . ARG A 1 628 ? -25.779 -83.366 -18.384 1.00 128.80 ? 891  ARG A NH2 1 
HETATM 4661 ZN ZN  . ZN  B 2 .   ? -6.524  -55.004 -23.687 1.00 27.92  2 1001 ZN  A ZN  1 
HETATM 4662 ZN ZN  . ZN  C 2 .   ? -25.839 -14.356 -13.186 1.00 57.56  2 1002 ZN  A ZN  1 
HETATM 4663 O  O1  A MES D 3 .   ? -28.536 -56.903 0.726   0.25 35.24  ? 1003 MES A O1  1 
HETATM 4664 O  O1  B MES D 3 .   ? -28.235 -57.144 0.403   0.25 883.01 ? 1003 MES A O1  1 
HETATM 4665 C  C2  A MES D 3 .   ? -27.872 -57.419 1.876   0.25 34.24  ? 1003 MES A C2  1 
HETATM 4666 C  C2  B MES D 3 .   ? -27.512 -57.529 1.567   0.25 888.66 ? 1003 MES A C2  1 
HETATM 4667 C  C3  A MES D 3 .   ? -26.410 -57.048 1.915   0.25 35.07  ? 1003 MES A C3  1 
HETATM 4668 C  C3  B MES D 3 .   ? -26.023 -57.570 1.314   0.25 888.74 ? 1003 MES A C3  1 
HETATM 4669 N  N4  A MES D 3 .   ? -25.729 -57.487 0.657   0.25 33.74  ? 1003 MES A N4  1 
HETATM 4670 N  N4  B MES D 3 .   ? -25.697 -58.497 0.180   0.25 889.17 ? 1003 MES A N4  1 
HETATM 4671 C  C5  A MES D 3 .   ? -26.441 -56.864 -0.503  0.25 35.26  ? 1003 MES A C5  1 
HETATM 4672 C  C5  B MES D 3 .   ? -26.539 -58.136 -1.019  0.25 878.82 ? 1003 MES A C5  1 
HETATM 4673 C  C6  A MES D 3 .   ? -27.895 -57.274 -0.486  0.25 34.73  ? 1003 MES A C6  1 
HETATM 4674 C  C6  B MES D 3 .   ? -28.010 -58.055 -0.664  0.25 876.03 ? 1003 MES A C6  1 
HETATM 4675 C  C7  A MES D 3 .   ? -24.257 -57.170 0.665   0.25 35.87  ? 1003 MES A C7  1 
HETATM 4676 C  C7  B MES D 3 .   ? -24.212 -58.529 -0.115  0.25 897.11 ? 1003 MES A C7  1 
HETATM 4677 C  C8  A MES D 3 .   ? -23.409 -58.179 -0.101  0.25 36.93  ? 1003 MES A C8  1 
HETATM 4678 C  C8  B MES D 3 .   ? -23.409 -57.391 0.527   0.25 909.83 ? 1003 MES A C8  1 
HETATM 4679 S  S   A MES D 3 .   ? -21.644 -57.871 -0.018  0.25 37.28  ? 1003 MES A S   1 
HETATM 4680 S  S   B MES D 3 .   ? -21.726 -57.775 1.026   0.25 928.80 ? 1003 MES A S   1 
HETATM 4681 O  O1S A MES D 3 .   ? -21.219 -58.385 1.261   0.25 32.12  ? 1003 MES A O1S 1 
HETATM 4682 O  O1S B MES D 3 .   ? -21.561 -59.199 0.933   0.25 935.38 ? 1003 MES A O1S 1 
HETATM 4683 O  O2S A MES D 3 .   ? -21.081 -58.580 -1.137  0.25 35.63  ? 1003 MES A O2S 1 
HETATM 4684 O  O2S B MES D 3 .   ? -20.855 -57.057 0.136   0.25 923.39 ? 1003 MES A O2S 1 
HETATM 4685 O  O3S A MES D 3 .   ? -21.470 -56.449 -0.144  0.25 37.03  ? 1003 MES A O3S 1 
HETATM 4686 O  O3S B MES D 3 .   ? -21.598 -57.296 2.373   0.25 933.29 ? 1003 MES A O3S 1 
HETATM 4687 S  S   . DMS E 4 .   ? -26.855 -61.703 -21.008 1.00 55.63  ? 1004 DMS A S   1 
HETATM 4688 O  O   . DMS E 4 .   ? -26.882 -62.425 -22.365 1.00 52.30  ? 1004 DMS A O   1 
HETATM 4689 C  C1  . DMS E 4 .   ? -28.063 -60.420 -21.113 1.00 54.47  ? 1004 DMS A C1  1 
HETATM 4690 C  C2  . DMS E 4 .   ? -25.387 -60.710 -21.086 1.00 51.02  ? 1004 DMS A C2  1 
HETATM 4691 S  S   . DMS F 4 .   ? -16.226 -69.149 -28.886 1.00 100.77 ? 1005 DMS A S   1 
HETATM 4692 O  O   . DMS F 4 .   ? -16.835 -67.783 -28.925 1.00 91.53  ? 1005 DMS A O   1 
HETATM 4693 C  C1  . DMS F 4 .   ? -16.909 -69.958 -27.460 1.00 93.01  ? 1005 DMS A C1  1 
HETATM 4694 C  C2  . DMS F 4 .   ? -14.562 -68.953 -28.309 1.00 92.29  ? 1005 DMS A C2  1 
HETATM 4695 S  S   . DMS G 4 .   ? -22.981 -47.830 -16.153 1.00 57.95  ? 1006 DMS A S   1 
HETATM 4696 O  O   . DMS G 4 .   ? -24.254 -47.456 -16.826 1.00 59.38  ? 1006 DMS A O   1 
HETATM 4697 C  C1  . DMS G 4 .   ? -21.753 -46.798 -16.894 1.00 58.29  ? 1006 DMS A C1  1 
HETATM 4698 C  C2  . DMS G 4 .   ? -22.493 -49.339 -16.919 1.00 58.78  ? 1006 DMS A C2  1 
HETATM 4699 P  P   . PO4 H 5 .   ? -4.010  -39.137 -23.948 1.00 73.35  ? 1007 PO4 A P   1 
HETATM 4700 O  O1  . PO4 H 5 .   ? -2.683  -39.885 -23.365 1.00 48.04  ? 1007 PO4 A O1  1 
HETATM 4701 O  O2  . PO4 H 5 .   ? -3.633  -37.720 -24.539 1.00 43.16  ? 1007 PO4 A O2  1 
HETATM 4702 O  O3  . PO4 H 5 .   ? -4.758  -39.972 -25.074 1.00 53.92  ? 1007 PO4 A O3  1 
HETATM 4703 O  O4  . PO4 H 5 .   ? -4.948  -38.994 -22.817 1.00 57.83  ? 1007 PO4 A O4  1 
HETATM 4704 P  P   . PO4 I 5 .   ? -18.164 -9.485  -29.433 1.00 116.85 ? 1008 PO4 A P   1 
HETATM 4705 O  O1  . PO4 I 5 .   ? -17.598 -9.781  -28.011 1.00 85.22  ? 1008 PO4 A O1  1 
HETATM 4706 O  O2  . PO4 I 5 .   ? -17.012 -9.309  -30.453 1.00 80.44  ? 1008 PO4 A O2  1 
HETATM 4707 O  O3  . PO4 I 5 .   ? -19.077 -10.654 -29.871 1.00 96.03  ? 1008 PO4 A O3  1 
HETATM 4708 O  O4  . PO4 I 5 .   ? -18.987 -8.190  -29.400 1.00 100.88 ? 1008 PO4 A O4  1 
HETATM 4709 C  C1  . PEG J 6 .   ? -16.130 -43.277 -41.277 1.00 72.12  ? 1009 PEG A C1  1 
HETATM 4710 O  O1  . PEG J 6 .   ? -17.536 -43.283 -41.131 1.00 67.04  ? 1009 PEG A O1  1 
HETATM 4711 C  C2  . PEG J 6 .   ? -15.687 -43.964 -42.532 1.00 79.85  ? 1009 PEG A C2  1 
HETATM 4712 O  O2  . PEG J 6 .   ? -16.198 -45.297 -42.567 1.00 77.77  ? 1009 PEG A O2  1 
HETATM 4713 C  C3  . PEG J 6 .   ? -16.219 -45.864 -43.875 1.00 74.75  ? 1009 PEG A C3  1 
HETATM 4714 C  C4  . PEG J 6 .   ? -15.158 -46.918 -44.000 1.00 78.30  ? 1009 PEG A C4  1 
HETATM 4715 O  O4  . PEG J 6 .   ? -15.701 -48.204 -44.270 1.00 81.27  ? 1009 PEG A O4  1 
HETATM 4716 C  C10 . YXK K 7 .   ? -26.245 -29.451 -19.851 0.26 25.15  ? 1010 YXK A C10 1 
HETATM 4717 F  F01 . YXK K 7 .   ? -28.294 -28.537 -16.017 0.26 30.87  ? 1010 YXK A F01 1 
HETATM 4718 C  C02 . YXK K 7 .   ? -28.253 -29.117 -17.212 0.26 28.73  ? 1010 YXK A C02 1 
HETATM 4719 F  F03 . YXK K 7 .   ? -29.289 -29.938 -17.268 0.26 27.65  ? 1010 YXK A F03 1 
HETATM 4720 F  F04 . YXK K 7 .   ? -28.470 -28.167 -18.113 0.26 29.90  ? 1010 YXK A F04 1 
HETATM 4721 C  C05 . YXK K 7 .   ? -26.956 -29.842 -17.435 0.26 27.80  ? 1010 YXK A C05 1 
HETATM 4722 N  N06 . YXK K 7 .   ? -26.820 -30.192 -18.851 0.26 26.59  ? 1010 YXK A N06 1 
HETATM 4723 C  C07 . YXK K 7 .   ? -27.167 -31.398 -19.399 0.26 26.39  ? 1010 YXK A C07 1 
HETATM 4724 C  C08 . YXK K 7 .   ? -26.789 -31.340 -20.698 0.26 25.91  ? 1010 YXK A C08 1 
HETATM 4725 N  N09 . YXK K 7 .   ? -26.212 -30.125 -20.984 0.26 25.66  ? 1010 YXK A N09 1 
HETATM 4726 C  C11 . YXK K 7 .   ? -25.681 -28.080 -19.652 0.26 23.71  ? 1010 YXK A C11 1 
HETATM 4727 C  C12 . YXK K 7 .   ? -25.135 -27.567 -20.905 0.26 22.66  ? 1010 YXK A C12 1 
HETATM 4728 N  N13 . YXK K 7 .   ? -24.667 -27.192 -21.873 0.26 21.91  ? 1010 YXK A N13 1 
HETATM 4729 CL CL  . CL  L 8 .   ? 4.344   -48.662 -29.853 1.00 43.62  ? 1011 CL  A CL  1 
HETATM 4730 O  O   . HOH M 9 .   ? -15.124 -49.230 -29.124 0.50 104.33 ? 1101 HOH A O   1 
HETATM 4731 O  O   . HOH M 9 .   ? -17.579 -65.427 -35.645 0.50 40.76  ? 1102 HOH A O   1 
HETATM 4732 O  O   . HOH M 9 .   ? -22.186 -43.764 -31.730 1.00 44.97  ? 1103 HOH A O   1 
HETATM 4733 O  O   . HOH M 9 .   ? -4.207  -53.297 -27.899 1.00 41.41  ? 1104 HOH A O   1 
HETATM 4734 O  O   . HOH M 9 .   ? -5.269  -12.396 -21.728 1.00 71.89  ? 1105 HOH A O   1 
HETATM 4735 O  O   . HOH M 9 .   ? -27.479 -65.293 -39.816 1.00 43.56  ? 1106 HOH A O   1 
HETATM 4736 O  O   . HOH M 9 .   ? -39.971 -24.063 -26.283 1.00 59.72  ? 1107 HOH A O   1 
HETATM 4737 O  O   . HOH M 9 .   ? -32.694 -51.751 -27.070 1.00 51.46  ? 1108 HOH A O   1 
HETATM 4738 O  O   . HOH M 9 .   ? -15.450 -21.846 -18.984 1.00 49.67  ? 1109 HOH A O   1 
HETATM 4739 O  O   . HOH M 9 .   ? 1.420   -21.383 -45.288 1.00 49.93  ? 1110 HOH A O   1 
HETATM 4740 O  O   . HOH M 9 .   ? -28.692 -45.654 2.541   1.00 51.41  ? 1111 HOH A O   1 
HETATM 4741 O  O   . HOH M 9 .   ? -7.583  -42.520 -42.680 1.00 58.64  ? 1112 HOH A O   1 
HETATM 4742 O  O   . HOH M 9 .   ? -34.389 -20.333 -23.804 1.00 52.12  ? 1113 HOH A O   1 
HETATM 4743 O  O   . HOH M 9 .   ? -28.737 -69.461 -14.138 1.00 46.32  ? 1114 HOH A O   1 
HETATM 4744 O  O   . HOH M 9 .   ? -14.670 -70.973 -17.938 0.50 32.95  ? 1115 HOH A O   1 
HETATM 4745 O  O   . HOH M 9 .   ? -23.389 -64.710 -38.608 0.50 43.28  ? 1116 HOH A O   1 
HETATM 4746 O  O   . HOH M 9 .   ? -6.766  -19.957 -26.731 1.00 43.68  ? 1117 HOH A O   1 
HETATM 4747 O  O   . HOH M 9 .   ? 5.902   -32.662 -38.049 1.00 45.31  ? 1118 HOH A O   1 
HETATM 4748 O  O   . HOH M 9 .   ? 10.054  -25.506 -32.109 1.00 63.26  ? 1119 HOH A O   1 
HETATM 4749 O  O   . HOH M 9 .   ? -22.572 -52.989 -46.682 1.00 63.07  ? 1120 HOH A O   1 
HETATM 4750 O  O   . HOH M 9 .   ? -22.087 -9.826  -9.428  1.00 56.69  ? 1121 HOH A O   1 
HETATM 4751 O  O   . HOH M 9 .   ? -13.395 -12.722 -27.428 1.00 59.86  ? 1122 HOH A O   1 
HETATM 4752 O  O   . HOH M 9 .   ? -31.904 -57.049 -21.728 1.00 40.30  ? 1123 HOH A O   1 
HETATM 4753 O  O   . HOH M 9 .   ? -19.366 -27.090 -40.031 1.00 30.30  ? 1124 HOH A O   1 
HETATM 4754 O  O   . HOH M 9 .   ? -4.455  -53.981 -11.884 1.00 51.60  ? 1125 HOH A O   1 
HETATM 4755 O  O   . HOH M 9 .   ? -40.418 -57.350 -6.213  1.00 54.25  ? 1126 HOH A O   1 
HETATM 4756 O  O   . HOH M 9 .   ? -28.991 -62.505 -25.241 1.00 34.52  ? 1127 HOH A O   1 
HETATM 4757 O  O   . HOH M 9 .   ? -7.710  -48.683 0.680   1.00 48.00  ? 1128 HOH A O   1 
HETATM 4758 O  O   . HOH M 9 .   ? -0.436  -10.812 -29.821 1.00 62.38  ? 1129 HOH A O   1 
HETATM 4759 O  O   . HOH M 9 .   ? 6.843   -35.113 -43.544 1.00 50.18  ? 1130 HOH A O   1 
HETATM 4760 O  O   . HOH M 9 .   ? -14.669 -17.101 -36.299 1.00 50.08  ? 1131 HOH A O   1 
HETATM 4761 O  O   . HOH M 9 .   ? -1.424  -41.200 -21.543 1.00 64.51  ? 1132 HOH A O   1 
HETATM 4762 O  O   . HOH M 9 .   ? 0.209   -32.610 -27.908 1.00 33.73  ? 1133 HOH A O   1 
HETATM 4763 O  O   . HOH M 9 .   ? -13.653 -74.247 -13.963 1.00 49.81  ? 1134 HOH A O   1 
HETATM 4764 O  O   . HOH M 9 .   ? -32.246 -70.499 -8.991  1.00 48.19  ? 1135 HOH A O   1 
HETATM 4765 O  O   . HOH M 9 .   ? -26.511 -25.501 -33.495 1.00 32.50  ? 1136 HOH A O   1 
HETATM 4766 O  O   . HOH M 9 .   ? -4.938  -15.112 -28.160 1.00 42.01  ? 1137 HOH A O   1 
HETATM 4767 O  O   . HOH M 9 .   ? 10.472  -38.880 -29.685 1.00 59.46  ? 1138 HOH A O   1 
HETATM 4768 O  O   . HOH M 9 .   ? -34.687 -62.585 0.510   1.00 29.60  ? 1139 HOH A O   1 
HETATM 4769 O  O   . HOH M 9 .   ? -6.399  -36.794 -20.651 1.00 44.23  ? 1140 HOH A O   1 
HETATM 4770 O  O   . HOH M 9 .   ? -32.372 -60.032 -18.935 1.00 42.78  ? 1141 HOH A O   1 
HETATM 4771 O  O   . HOH M 9 .   ? -40.209 -60.941 -11.390 1.00 34.65  ? 1142 HOH A O   1 
HETATM 4772 O  O   . HOH M 9 .   ? -25.512 -25.596 -17.665 0.26 24.77  ? 1143 HOH A O   1 
HETATM 4773 O  O   . HOH M 9 .   ? -39.141 -60.883 -4.460  1.00 47.71  ? 1144 HOH A O   1 
HETATM 4774 O  O   . HOH M 9 .   ? -27.924 -46.929 -0.087  1.00 54.99  ? 1145 HOH A O   1 
HETATM 4775 O  O   . HOH M 9 .   ? -7.424  -47.238 -18.077 1.00 37.24  ? 1146 HOH A O   1 
HETATM 4776 O  O   . HOH M 9 .   ? 4.192   -28.801 -44.165 1.00 43.34  ? 1147 HOH A O   1 
HETATM 4777 O  O   . HOH M 9 .   ? -24.828 -14.079 -4.752  1.00 48.11  ? 1148 HOH A O   1 
HETATM 4778 O  O   . HOH M 9 .   ? 5.996   -31.058 -19.292 1.00 42.22  ? 1149 HOH A O   1 
HETATM 4779 O  O   . HOH M 9 .   ? -30.900 -73.398 -18.585 1.00 57.73  ? 1150 HOH A O   1 
HETATM 4780 O  O   . HOH M 9 .   ? -32.770 -63.155 -15.177 1.00 38.04  ? 1151 HOH A O   1 
HETATM 4781 O  O   . HOH M 9 .   ? -0.037  -31.002 -23.090 1.00 26.53  ? 1152 HOH A O   1 
HETATM 4782 O  O   . HOH M 9 .   ? -20.428 -28.907 -25.018 1.00 44.34  ? 1153 HOH A O   1 
HETATM 4783 O  O   . HOH M 9 .   ? 1.788   -32.169 -38.831 1.00 33.89  ? 1154 HOH A O   1 
HETATM 4784 O  O   . HOH M 9 .   ? -38.889 -57.098 -20.589 1.00 54.30  ? 1155 HOH A O   1 
HETATM 4785 O  O   . HOH M 9 .   ? 11.416  -34.632 -33.061 1.00 41.35  ? 1156 HOH A O   1 
HETATM 4786 O  O   . HOH M 9 .   ? 4.722   -16.307 -21.652 1.00 54.53  ? 1157 HOH A O   1 
HETATM 4787 O  O   . HOH M 9 .   ? -16.090 -11.671 -29.734 1.00 58.72  ? 1158 HOH A O   1 
HETATM 4788 O  O   . HOH M 9 .   ? -35.097 -50.088 -12.807 1.00 54.49  ? 1159 HOH A O   1 
HETATM 4789 O  O   . HOH M 9 .   ? -14.443 -21.094 -16.866 1.00 54.93  ? 1160 HOH A O   1 
HETATM 4790 O  O   . HOH M 9 .   ? -9.037  -58.706 -13.226 1.00 33.76  ? 1161 HOH A O   1 
HETATM 4791 O  O   . HOH M 9 .   ? -38.174 -67.257 -8.066  1.00 51.48  ? 1162 HOH A O   1 
HETATM 4792 O  O   . HOH M 9 .   ? -12.420 -57.890 0.000   0.50 23.54  ? 1163 HOH A O   1 
HETATM 4793 O  O   . HOH M 9 .   ? -3.300  -19.899 -23.414 1.00 40.19  ? 1164 HOH A O   1 
HETATM 4794 O  O   . HOH M 9 .   ? -5.735  -32.709 -17.515 1.00 44.87  ? 1165 HOH A O   1 
HETATM 4795 O  O   . HOH M 9 .   ? -3.816  -61.267 -15.427 1.00 39.28  ? 1166 HOH A O   1 
HETATM 4796 O  O   . HOH M 9 .   ? -20.802 -49.705 0.981   1.00 47.48  ? 1167 HOH A O   1 
HETATM 4797 O  O   . HOH M 9 .   ? -0.270  -52.243 -35.736 1.00 60.84  ? 1168 HOH A O   1 
HETATM 4798 O  O   . HOH M 9 .   ? -14.701 -63.720 -0.442  1.00 30.48  ? 1169 HOH A O   1 
HETATM 4799 O  O   . HOH M 9 .   ? -22.404 -50.699 -9.191  1.00 34.83  ? 1170 HOH A O   1 
HETATM 4800 O  O   . HOH M 9 .   ? 2.751   -39.177 -27.187 1.00 31.76  ? 1171 HOH A O   1 
HETATM 4801 O  O   . HOH M 9 .   ? -35.505 -66.479 -0.685  1.00 42.03  ? 1172 HOH A O   1 
HETATM 4802 O  O   . HOH M 9 .   ? -18.972 -69.355 -8.278  1.00 28.25  ? 1173 HOH A O   1 
HETATM 4803 O  O   . HOH M 9 .   ? -10.956 -62.069 -18.633 1.00 22.02  ? 1174 HOH A O   1 
HETATM 4804 O  O   . HOH M 9 .   ? -29.714 -33.112 -28.740 1.00 59.41  ? 1175 HOH A O   1 
HETATM 4805 O  O   . HOH M 9 .   ? -3.979  -57.227 -9.859  1.00 40.41  ? 1176 HOH A O   1 
HETATM 4806 O  O   . HOH M 9 .   ? -9.732  -63.385 -33.226 1.00 50.03  ? 1177 HOH A O   1 
HETATM 4807 O  O   . HOH M 9 .   ? -20.726 -19.274 -38.678 1.00 52.66  ? 1178 HOH A O   1 
HETATM 4808 O  O   . HOH M 9 .   ? -15.086 -53.999 -39.627 1.00 36.43  ? 1179 HOH A O   1 
HETATM 4809 O  O   . HOH M 9 .   ? 1.679   -19.423 -19.740 1.00 60.66  ? 1180 HOH A O   1 
HETATM 4810 O  O   . HOH M 9 .   ? -22.142 -74.069 -11.718 1.00 34.15  ? 1181 HOH A O   1 
HETATM 4811 O  O   . HOH M 9 .   ? -14.892 -34.501 -29.087 1.00 22.86  ? 1182 HOH A O   1 
HETATM 4812 O  O   . HOH M 9 .   ? -5.837  -58.241 -37.082 1.00 64.57  ? 1183 HOH A O   1 
HETATM 4813 O  O   . HOH M 9 .   ? -5.144  -48.391 -28.708 1.00 32.41  ? 1184 HOH A O   1 
HETATM 4814 O  O   . HOH M 9 .   ? 1.163   -41.314 -24.531 1.00 38.60  ? 1185 HOH A O   1 
HETATM 4815 O  O   . HOH M 9 .   ? -31.795 -59.859 -15.838 1.00 32.93  ? 1186 HOH A O   1 
HETATM 4816 O  O   . HOH M 9 .   ? -9.277  -21.162 -27.096 1.00 37.31  ? 1187 HOH A O   1 
HETATM 4817 O  O   . HOH M 9 .   ? -8.750  -26.115 -44.466 1.00 49.41  ? 1188 HOH A O   1 
HETATM 4818 O  O   . HOH M 9 .   ? -18.883 -65.020 -7.153  1.00 24.58  ? 1189 HOH A O   1 
HETATM 4819 O  O   . HOH M 9 .   ? 9.278   -23.759 -35.911 1.00 59.44  ? 1190 HOH A O   1 
HETATM 4820 O  O   . HOH M 9 .   ? -12.243 -36.859 -39.578 0.46 57.25  ? 1191 HOH A O   1 
HETATM 4821 O  O   . HOH M 9 .   ? -8.448  -64.627 -6.897  1.00 43.19  ? 1192 HOH A O   1 
HETATM 4822 O  O   . HOH M 9 .   ? -34.216 -28.818 -30.266 1.00 50.20  ? 1193 HOH A O   1 
HETATM 4823 O  O   . HOH M 9 .   ? -28.397 -49.587 0.147   1.00 35.22  ? 1194 HOH A O   1 
HETATM 4824 O  O   . HOH M 9 .   ? -30.048 -49.849 -27.209 1.00 50.32  ? 1195 HOH A O   1 
HETATM 4825 O  O   . HOH M 9 .   ? -18.085 -61.756 -2.987  1.00 29.50  ? 1196 HOH A O   1 
HETATM 4826 O  O   . HOH M 9 .   ? -22.539 -65.509 -23.817 1.00 43.99  ? 1197 HOH A O   1 
HETATM 4827 O  O   . HOH M 9 .   ? 5.463   -29.852 -21.540 1.00 31.40  ? 1198 HOH A O   1 
HETATM 4828 O  O   . HOH M 9 .   ? -38.386 -60.693 -14.417 1.00 44.27  ? 1199 HOH A O   1 
HETATM 4829 O  O   . HOH M 9 .   ? -11.307 -41.100 -19.800 1.00 55.82  ? 1200 HOH A O   1 
HETATM 4830 O  O   . HOH M 9 .   ? -3.433  -54.758 -36.414 1.00 54.03  ? 1201 HOH A O   1 
HETATM 4831 O  O   . HOH M 9 .   ? -10.925 -47.953 -39.256 1.00 27.84  ? 1202 HOH A O   1 
HETATM 4832 O  O   . HOH M 9 .   ? -4.058  -22.777 -25.236 1.00 32.59  ? 1203 HOH A O   1 
HETATM 4833 O  O   . HOH M 9 .   ? -19.922 -65.941 -37.658 0.50 32.30  ? 1204 HOH A O   1 
HETATM 4834 O  O   . HOH M 9 .   ? -37.925 -37.862 -26.480 1.00 66.78  ? 1205 HOH A O   1 
HETATM 4835 O  O   . HOH M 9 .   ? -20.676 -31.353 -29.438 1.00 39.10  ? 1206 HOH A O   1 
HETATM 4836 O  O   . HOH M 9 .   ? -23.022 -27.139 -24.538 1.00 46.14  ? 1207 HOH A O   1 
HETATM 4837 O  O   . HOH M 9 .   ? -14.096 -51.921 -5.780  1.00 32.27  ? 1208 HOH A O   1 
HETATM 4838 O  O   . HOH M 9 .   ? -20.269 -75.601 -14.305 1.00 60.63  ? 1209 HOH A O   1 
HETATM 4839 O  O   . HOH M 9 .   ? 4.277   -26.400 -29.329 1.00 41.86  ? 1210 HOH A O   1 
HETATM 4840 O  O   . HOH M 9 .   ? -21.267 -49.060 -35.098 1.00 46.04  ? 1211 HOH A O   1 
HETATM 4841 O  O   . HOH M 9 .   ? -3.142  -54.858 -17.986 1.00 32.60  ? 1212 HOH A O   1 
HETATM 4842 O  O   . HOH M 9 .   ? -14.236 -44.253 -3.879  1.00 55.50  ? 1213 HOH A O   1 
HETATM 4843 O  O   . HOH M 9 .   ? -22.824 -20.733 -37.917 1.00 46.22  ? 1214 HOH A O   1 
HETATM 4844 O  O   . HOH M 9 .   ? -11.984 -30.478 -46.687 1.00 66.77  ? 1215 HOH A O   1 
HETATM 4845 O  O   . HOH M 9 .   ? -5.417  -59.838 -0.746  1.00 42.38  ? 1216 HOH A O   1 
HETATM 4846 O  O   . HOH M 9 .   ? -25.070 -35.073 -23.688 0.26 36.65  ? 1217 HOH A O   1 
HETATM 4847 O  O   . HOH M 9 .   ? -39.547 -55.104 -6.349  1.00 43.93  ? 1218 HOH A O   1 
HETATM 4848 O  O   . HOH M 9 .   ? -4.364  -65.154 -15.075 1.00 43.44  ? 1219 HOH A O   1 
HETATM 4849 O  O   . HOH M 9 .   ? -26.212 -29.718 -23.754 0.26 16.63  ? 1220 HOH A O   1 
HETATM 4850 O  O   . HOH M 9 .   ? -20.497 -67.036 -25.491 1.00 38.64  ? 1221 HOH A O   1 
HETATM 4851 O  O   . HOH M 9 .   ? 5.754   -38.463 -24.357 1.00 42.99  ? 1222 HOH A O   1 
HETATM 4852 O  O   . HOH M 9 .   ? -13.263 -68.272 -6.163  1.00 47.90  ? 1223 HOH A O   1 
HETATM 4853 O  O   . HOH M 9 .   ? -13.092 -53.110 -40.783 1.00 52.58  ? 1224 HOH A O   1 
HETATM 4854 O  O   . HOH M 9 .   ? 9.966   -37.974 -38.971 1.00 46.97  ? 1225 HOH A O   1 
HETATM 4855 O  O   . HOH M 9 .   ? -33.606 -57.021 -19.563 1.00 52.45  ? 1226 HOH A O   1 
HETATM 4856 O  O   . HOH M 9 .   ? -24.990 -53.228 -1.824  1.00 29.96  ? 1227 HOH A O   1 
HETATM 4857 O  O   . HOH M 9 .   ? 0.172   -64.356 -19.189 1.00 38.89  ? 1228 HOH A O   1 
HETATM 4858 O  O   . HOH M 9 .   ? 2.723   -64.316 -20.624 1.00 23.55  ? 1229 HOH A O   1 
HETATM 4859 O  O   . HOH M 9 .   ? 7.585   -49.249 -30.609 1.00 59.37  ? 1230 HOH A O   1 
HETATM 4860 O  O   . HOH M 9 .   ? -14.261 -56.155 -1.527  1.00 27.10  ? 1231 HOH A O   1 
HETATM 4861 O  O   . HOH M 9 .   ? -13.722 -50.926 -43.090 1.00 51.33  ? 1232 HOH A O   1 
HETATM 4862 O  O   . HOH M 9 .   ? 7.737   -21.902 -24.232 1.00 42.90  ? 1233 HOH A O   1 
HETATM 4863 O  O   . HOH M 9 .   ? -19.346 -17.003 -11.213 1.00 49.53  ? 1234 HOH A O   1 
HETATM 4864 O  O   . HOH M 9 .   ? -4.440  -61.901 -4.680  1.00 45.29  ? 1235 HOH A O   1 
HETATM 4865 O  O   . HOH M 9 .   ? -15.561 -65.429 -33.861 1.00 53.11  ? 1236 HOH A O   1 
HETATM 4866 O  O   . HOH M 9 .   ? 10.841  -40.632 -37.934 1.00 55.17  ? 1237 HOH A O   1 
HETATM 4867 O  O   . HOH M 9 .   ? -27.792 -16.587 -32.263 1.00 42.46  ? 1238 HOH A O   1 
HETATM 4868 O  O   . HOH M 9 .   ? -24.447 -68.897 -27.769 1.00 42.22  ? 1239 HOH A O   1 
HETATM 4869 O  O   . HOH M 9 .   ? -41.190 -57.890 -10.149 0.50 38.68  ? 1240 HOH A O   1 
HETATM 4870 O  O   . HOH M 9 .   ? -22.967 -75.038 -9.105  1.00 40.81  ? 1241 HOH A O   1 
HETATM 4871 O  O   . HOH M 9 .   ? -42.459 -62.660 -5.151  1.00 49.11  ? 1242 HOH A O   1 
HETATM 4872 O  O   . HOH M 9 .   ? -19.245 -20.270 -40.600 1.00 50.99  ? 1243 HOH A O   1 
HETATM 4873 O  O   . HOH M 9 .   ? -14.987 -48.313 -18.839 1.00 39.96  ? 1244 HOH A O   1 
HETATM 4874 O  O   . HOH M 9 .   ? -27.779 -22.887 -26.604 1.00 32.56  ? 1245 HOH A O   1 
HETATM 4875 O  O   . HOH M 9 .   ? -0.564  -35.551 -28.066 1.00 36.74  ? 1246 HOH A O   1 
HETATM 4876 O  O   . HOH M 9 .   ? -5.627  -58.881 -12.103 1.00 47.51  ? 1247 HOH A O   1 
HETATM 4877 O  O   . HOH M 9 .   ? -3.994  -56.739 -13.217 1.00 46.21  ? 1248 HOH A O   1 
HETATM 4878 O  O   . HOH M 9 .   ? -17.040 -28.382 -41.253 1.00 58.35  ? 1249 HOH A O   1 
HETATM 4879 O  O   . HOH M 9 .   ? -35.835 -57.099 -30.986 1.00 63.21  ? 1250 HOH A O   1 
HETATM 4880 O  O   . HOH M 9 .   ? -30.431 -61.032 -32.429 1.00 63.80  ? 1251 HOH A O   1 
HETATM 4881 O  O   . HOH M 9 .   ? -13.141 -32.417 -45.163 0.46 36.31  ? 1252 HOH A O   1 
HETATM 4882 O  O   . HOH M 9 .   ? -27.292 -56.546 -39.790 1.00 45.71  ? 1253 HOH A O   1 
HETATM 4883 O  O   . HOH M 9 .   ? -17.049 -51.602 -15.481 1.00 21.64  ? 1254 HOH A O   1 
HETATM 4884 O  O   . HOH M 9 .   ? 10.662  -26.778 -28.844 1.00 51.07  ? 1255 HOH A O   1 
HETATM 4885 O  O   . HOH M 9 .   ? -22.898 -33.451 -36.942 1.00 30.51  ? 1256 HOH A O   1 
HETATM 4886 O  O   . HOH M 9 .   ? -26.464 -71.214 -3.333  1.00 53.78  ? 1257 HOH A O   1 
HETATM 4887 O  O   . HOH M 9 .   ? -13.889 -49.329 -32.281 0.50 20.68  ? 1258 HOH A O   1 
HETATM 4888 O  O   . HOH M 9 .   ? -21.979 -31.473 -39.849 1.00 56.19  ? 1259 HOH A O   1 
HETATM 4889 O  O   . HOH M 9 .   ? -30.079 -56.501 -34.619 1.00 47.72  ? 1260 HOH A O   1 
HETATM 4890 O  O   . HOH M 9 .   ? -15.419 -26.832 -46.036 1.00 59.28  ? 1261 HOH A O   1 
HETATM 4891 O  O   . HOH M 9 .   ? 7.815   -43.048 -36.090 1.00 43.63  ? 1262 HOH A O   1 
HETATM 4892 O  O   . HOH M 9 .   ? -30.056 -60.605 -23.187 1.00 41.86  ? 1263 HOH A O   1 
HETATM 4893 O  O   . HOH M 9 .   ? -14.158 -45.599 2.800   1.00 67.36  ? 1264 HOH A O   1 
HETATM 4894 O  O   . HOH M 9 .   ? 0.553   -70.467 -21.363 1.00 39.55  ? 1265 HOH A O   1 
HETATM 4895 O  O   . HOH M 9 .   ? -19.887 -37.706 -36.867 1.00 33.12  ? 1266 HOH A O   1 
HETATM 4896 O  O   . HOH M 9 .   ? -22.562 -27.011 -19.058 0.26 34.65  ? 1267 HOH A O   1 
HETATM 4897 O  O   . HOH M 9 .   ? -17.879 -34.618 -42.917 0.46 26.56  ? 1268 HOH A O   1 
HETATM 4898 O  O   . HOH M 9 .   ? -5.865  -50.031 -18.883 1.00 34.34  ? 1269 HOH A O   1 
HETATM 4899 O  O   . HOH M 9 .   ? -18.983 -75.925 -16.541 1.00 57.18  ? 1270 HOH A O   1 
HETATM 4900 O  O   . HOH M 9 .   ? -39.027 -54.615 -18.948 1.00 47.07  ? 1271 HOH A O   1 
HETATM 4901 O  O   . HOH M 9 .   ? -5.099  -33.903 -20.539 1.00 57.31  ? 1272 HOH A O   1 
HETATM 4902 O  O   . HOH M 9 .   ? 9.944   -29.760 -16.303 0.26 8.97   ? 1273 HOH A O   1 
HETATM 4903 O  O   . HOH M 9 .   ? -29.591 -62.533 -33.882 1.00 56.33  ? 1274 HOH A O   1 
HETATM 4904 O  O   . HOH M 9 .   ? -27.983 -18.242 -35.373 1.00 53.78  ? 1275 HOH A O   1 
HETATM 4905 O  O   . HOH M 9 .   ? -8.280  -16.781 -39.324 1.00 44.74  ? 1276 HOH A O   1 
HETATM 4906 O  O   . HOH M 9 .   ? -37.038 -49.899 -5.492  1.00 40.94  ? 1277 HOH A O   1 
HETATM 4907 O  O   . HOH M 9 .   ? -29.986 -59.322 -19.832 1.00 36.31  ? 1278 HOH A O   1 
HETATM 4908 O  O   . HOH M 9 .   ? -8.770  -37.104 -19.522 1.00 48.42  ? 1279 HOH A O   1 
HETATM 4909 O  O   . HOH M 9 .   ? 4.031   -37.660 -44.405 1.00 60.87  ? 1280 HOH A O   1 
HETATM 4910 O  O   . HOH M 9 .   ? -35.596 -57.954 -27.417 1.00 65.35  ? 1281 HOH A O   1 
HETATM 4911 O  O   . HOH M 9 .   ? -0.207  -55.048 -33.300 1.00 53.84  ? 1282 HOH A O   1 
HETATM 4912 O  O   . HOH M 9 .   ? -19.993 -45.974 -25.336 1.00 47.38  ? 1283 HOH A O   1 
HETATM 4913 O  O   . HOH M 9 .   ? -35.578 -59.151 -0.517  1.00 57.93  ? 1284 HOH A O   1 
HETATM 4914 O  O   . HOH M 9 .   ? -3.953  -52.439 -38.500 1.00 57.84  ? 1285 HOH A O   1 
HETATM 4915 O  O   . HOH M 9 .   ? -13.773 -53.327 -1.539  1.00 32.92  ? 1286 HOH A O   1 
HETATM 4916 O  O   . HOH M 9 .   ? -9.072  -70.838 -14.788 1.00 41.03  ? 1287 HOH A O   1 
HETATM 4917 O  O   . HOH M 9 .   ? -11.147 -40.364 -38.988 0.50 69.77  ? 1288 HOH A O   1 
HETATM 4918 O  O   . HOH M 9 .   ? -14.826 -53.915 -4.055  1.00 31.19  ? 1289 HOH A O   1 
HETATM 4919 O  O   . HOH M 9 .   ? -8.700  -63.408 -31.200 1.00 49.34  ? 1290 HOH A O   1 
HETATM 4920 O  O   . HOH M 9 .   ? -7.272  -57.238 -1.065  1.00 51.98  ? 1291 HOH A O   1 
HETATM 4921 O  O   . HOH M 9 .   ? 3.228   -43.156 -42.910 1.00 56.99  ? 1292 HOH A O   1 
HETATM 4922 O  O   . HOH M 9 .   ? -7.535  -29.775 -46.075 1.00 49.17  ? 1293 HOH A O   1 
HETATM 4923 O  O   . HOH M 9 .   ? -17.764 -71.287 -22.945 1.00 50.33  ? 1294 HOH A O   1 
HETATM 4924 O  O   . HOH M 9 .   ? -17.299 -56.963 -43.799 1.00 32.10  ? 1295 HOH A O   1 
HETATM 4925 O  O   . HOH M 9 .   ? -5.749  -58.450 -30.407 0.50 38.12  ? 1296 HOH A O   1 
HETATM 4926 O  O   . HOH M 9 .   ? -4.845  -56.174 -31.499 1.00 28.01  ? 1297 HOH A O   1 
HETATM 4927 O  O   . HOH M 9 .   ? -18.135 -69.239 -24.862 1.00 38.91  ? 1298 HOH A O   1 
HETATM 4928 O  O   . HOH M 9 .   ? -5.831  -48.749 -21.242 1.00 31.78  ? 1299 HOH A O   1 
HETATM 4929 O  O   . HOH M 9 .   ? -35.837 -53.816 -3.374  1.00 39.62  ? 1300 HOH A O   1 
HETATM 4930 O  O   . HOH M 9 .   ? -13.167 -41.411 -38.489 0.50 72.82  ? 1301 HOH A O   1 
HETATM 4931 O  O   . HOH M 9 .   ? -27.130 -15.384 -19.956 1.00 49.64  ? 1302 HOH A O   1 
HETATM 4932 O  O   . HOH M 9 .   ? 5.744   -45.051 -26.522 1.00 44.60  ? 1303 HOH A O   1 
HETATM 4933 O  O   . HOH M 9 .   ? -10.775 -45.998 3.828   1.00 56.57  ? 1304 HOH A O   1 
HETATM 4934 O  O   . HOH M 9 .   ? 0.210   -48.462 -36.140 1.00 47.44  ? 1305 HOH A O   1 
HETATM 4935 O  O   . HOH M 9 .   ? -17.406 -41.461 -37.236 1.00 49.06  ? 1306 HOH A O   1 
HETATM 4936 O  O   . HOH M 9 .   ? -2.359  -39.436 -45.830 1.00 39.90  ? 1307 HOH A O   1 
HETATM 4937 O  O   . HOH M 9 .   ? -7.219  -49.222 -6.197  1.00 53.87  ? 1308 HOH A O   1 
HETATM 4938 O  O   . HOH M 9 .   ? -16.009 -9.092  -33.331 1.00 59.73  ? 1309 HOH A O   1 
HETATM 4939 O  O   . HOH M 9 .   ? -15.596 -54.382 -44.060 1.00 57.41  ? 1310 HOH A O   1 
HETATM 4940 O  O   . HOH M 9 .   ? -37.405 -52.158 -12.883 1.00 28.58  ? 1311 HOH A O   1 
HETATM 4941 O  O   . HOH M 9 .   ? -24.857 -34.781 -15.221 0.26 37.07  ? 1312 HOH A O   1 
HETATM 4942 O  O   . HOH M 9 .   ? -39.862 -64.478 -2.071  1.00 56.50  ? 1313 HOH A O   1 
HETATM 4943 O  O   . HOH M 9 .   ? -37.636 -67.992 -12.395 1.00 51.61  ? 1314 HOH A O   1 
HETATM 4944 O  O   . HOH M 9 .   ? -5.950  -68.683 -7.359  1.00 37.99  ? 1315 HOH A O   1 
HETATM 4945 O  O   . HOH M 9 .   ? -2.578  -57.602 -27.336 1.00 35.77  ? 1316 HOH A O   1 
HETATM 4946 O  O   . HOH M 9 .   ? 3.714   -31.371 -36.970 1.00 30.99  ? 1317 HOH A O   1 
HETATM 4947 O  O   . HOH M 9 .   ? 1.047   -38.447 -21.272 1.00 49.46  ? 1318 HOH A O   1 
HETATM 4948 O  O   . HOH M 9 .   ? -13.831 -11.150 -31.620 1.00 58.95  ? 1319 HOH A O   1 
HETATM 4949 O  O   . HOH M 9 .   ? -3.642  -70.767 -9.105  1.00 36.33  ? 1320 HOH A O   1 
HETATM 4950 O  O   . HOH M 9 .   ? -6.297  -42.777 -20.640 1.00 40.10  ? 1321 HOH A O   1 
HETATM 4951 O  O   . HOH M 9 .   ? -24.488 -57.440 -46.707 1.00 49.94  ? 1322 HOH A O   1 
HETATM 4952 O  O   . HOH M 9 .   ? 10.642  -29.214 -34.109 1.00 53.23  ? 1323 HOH A O   1 
HETATM 4953 O  O   . HOH M 9 .   ? 3.566   -33.716 -14.383 1.00 51.50  ? 1324 HOH A O   1 
HETATM 4954 O  O   . HOH M 9 .   ? -26.640 -64.672 1.703   1.00 45.92  ? 1325 HOH A O   1 
HETATM 4955 O  O   . HOH M 9 .   ? 13.569  -30.081 -19.594 1.00 51.22  ? 1326 HOH A O   1 
HETATM 4956 O  O   . HOH M 9 .   ? -22.627 -29.504 -14.572 1.00 61.73  ? 1327 HOH A O   1 
HETATM 4957 O  O   . HOH M 9 .   ? -14.768 -56.641 -41.883 1.00 32.22  ? 1328 HOH A O   1 
HETATM 4958 O  O   . HOH M 9 .   ? -34.804 -59.270 -29.218 1.00 56.18  ? 1329 HOH A O   1 
HETATM 4959 O  O   . HOH M 9 .   ? -25.106 -23.166 -41.712 0.50 37.68  ? 1330 HOH A O   1 
HETATM 4960 O  O   . HOH M 9 .   ? -12.449 -66.718 -29.816 1.00 38.62  ? 1331 HOH A O   1 
HETATM 4961 O  O   . HOH M 9 .   ? -31.134 -71.549 -13.682 1.00 55.47  ? 1332 HOH A O   1 
HETATM 4962 O  O   . HOH M 9 .   ? -35.794 -50.609 -22.858 1.00 62.20  ? 1333 HOH A O   1 
HETATM 4963 O  O   . HOH M 9 .   ? -34.155 -69.821 -18.546 1.00 38.62  ? 1334 HOH A O   1 
HETATM 4964 O  O   . HOH M 9 .   ? -4.166  -34.069 -14.244 1.00 60.26  ? 1335 HOH A O   1 
HETATM 4965 O  O   . HOH M 9 .   ? -0.711  -32.235 -25.602 1.00 29.65  ? 1336 HOH A O   1 
HETATM 4966 O  O   . HOH M 9 .   ? -19.508 -64.412 -2.872  1.00 52.92  ? 1337 HOH A O   1 
HETATM 4967 O  O   . HOH M 9 .   ? -19.433 -37.860 -26.102 1.00 70.20  ? 1338 HOH A O   1 
HETATM 4968 O  O   . HOH M 9 .   ? -5.857  -68.216 -27.541 1.00 30.96  ? 1339 HOH A O   1 
HETATM 4969 O  O   . HOH M 9 .   ? 9.480   -43.880 -34.166 0.50 71.30  ? 1340 HOH A O   1 
HETATM 4970 O  O   . HOH M 9 .   ? -33.896 -46.735 -15.428 1.00 54.62  ? 1341 HOH A O   1 
HETATM 4971 O  O   . HOH M 9 .   ? -2.133  -70.175 -17.821 1.00 45.60  ? 1342 HOH A O   1 
HETATM 4972 O  O   . HOH M 9 .   ? 8.692   -40.536 -31.384 1.00 45.15  ? 1343 HOH A O   1 
HETATM 4973 O  O   . HOH M 9 .   ? -3.737  -56.293 -7.088  1.00 34.30  ? 1344 HOH A O   1 
HETATM 4974 O  O   . HOH M 9 .   ? -22.912 -36.587 -32.564 1.00 58.34  ? 1345 HOH A O   1 
HETATM 4975 O  O   . HOH M 9 .   ? -26.625 -67.554 -27.917 1.00 28.39  ? 1346 HOH A O   1 
HETATM 4976 O  O   . HOH M 9 .   ? -2.919  -57.732 -24.446 1.00 26.60  ? 1347 HOH A O   1 
HETATM 4977 O  O   . HOH M 9 .   ? -24.602 -33.023 -17.023 0.26 49.11  ? 1348 HOH A O   1 
HETATM 4978 O  O   . HOH M 9 .   ? 5.938   -39.994 -20.481 1.00 64.32  ? 1349 HOH A O   1 
HETATM 4979 O  O   . HOH M 9 .   ? -21.105 -45.535 -10.738 0.40 41.57  ? 1350 HOH A O   1 
HETATM 4980 O  O   . HOH M 9 .   ? -37.559 -54.351 -24.849 1.00 60.33  ? 1351 HOH A O   1 
HETATM 4981 O  O   . HOH M 9 .   ? -8.498  -27.244 -46.305 0.50 32.40  ? 1352 HOH A O   1 
HETATM 4982 O  O   . HOH M 9 .   ? -8.211  -71.837 -20.034 1.00 58.82  ? 1353 HOH A O   1 
HETATM 4983 O  O   . HOH M 9 .   ? -24.178 -68.257 -38.527 1.00 59.42  ? 1354 HOH A O   1 
HETATM 4984 O  O   . HOH M 9 .   ? -7.811  -61.898 -33.532 1.00 48.08  ? 1355 HOH A O   1 
HETATM 4985 O  O   . HOH M 9 .   ? -40.763 -24.766 -17.909 1.00 68.15  ? 1356 HOH A O   1 
HETATM 4986 O  O   . HOH M 9 .   ? -32.215 -18.414 -30.851 1.00 44.93  ? 1357 HOH A O   1 
HETATM 4987 O  O   . HOH M 9 .   ? -12.186 -43.709 -16.202 1.00 48.46  ? 1358 HOH A O   1 
HETATM 4988 O  O   . HOH M 9 .   ? -27.052 -73.499 -4.920  1.00 50.69  ? 1359 HOH A O   1 
HETATM 4989 O  O   . HOH M 9 .   ? -27.083 -26.673 -35.803 1.00 41.23  ? 1360 HOH A O   1 
HETATM 4990 O  O   . HOH M 9 .   ? -11.730 -71.713 -15.462 1.00 26.32  ? 1361 HOH A O   1 
HETATM 4991 O  O   . HOH M 9 .   ? -35.452 -67.545 -5.254  1.00 58.01  ? 1362 HOH A O   1 
HETATM 4992 O  O   . HOH M 9 .   ? -23.358 -48.809 -42.004 1.00 48.25  ? 1363 HOH A O   1 
HETATM 4993 O  O   . HOH M 9 .   ? -20.111 -31.003 -26.787 1.00 35.58  ? 1364 HOH A O   1 
HETATM 4994 O  O   . HOH M 9 .   ? -28.856 -68.882 -22.952 1.00 64.26  ? 1365 HOH A O   1 
HETATM 4995 O  O   . HOH M 9 .   ? -23.325 -47.884 -34.027 1.00 52.33  ? 1366 HOH A O   1 
HETATM 4996 O  O   . HOH M 9 .   ? -26.371 -27.752 -42.780 1.00 61.44  ? 1367 HOH A O   1 
HETATM 4997 O  O   . HOH M 9 .   ? 0.712   -31.319 -47.177 1.00 46.74  ? 1368 HOH A O   1 
HETATM 4998 O  O   . HOH M 9 .   ? -23.430 -29.603 -17.293 0.26 5.94   ? 1369 HOH A O   1 
HETATM 4999 O  O   . HOH M 9 .   ? -9.330  -70.167 -21.939 1.00 57.30  ? 1370 HOH A O   1 
HETATM 5000 O  O   . HOH M 9 .   ? -22.249 -41.408 -33.930 1.00 57.50  ? 1371 HOH A O   1 
HETATM 5001 O  O   . HOH M 9 .   ? -12.325 -37.401 -22.054 1.00 47.78  ? 1372 HOH A O   1 
HETATM 5002 O  O   . HOH M 9 .   ? -31.179 -44.706 -15.676 1.00 48.68  ? 1373 HOH A O   1 
HETATM 5003 O  O   . HOH M 9 .   ? 0.656   -44.812 -36.858 1.00 50.15  ? 1374 HOH A O   1 
HETATM 5004 O  O   . HOH M 9 .   ? -12.957 -32.577 -20.562 1.00 28.07  ? 1375 HOH A O   1 
HETATM 5005 O  O   . HOH M 9 .   ? -10.066 -25.556 -12.075 1.00 56.07  ? 1376 HOH A O   1 
HETATM 5006 O  O   . HOH M 9 .   ? 11.423  -37.185 -18.881 1.00 43.98  ? 1377 HOH A O   1 
HETATM 5007 O  O   . HOH M 9 .   ? -16.672 -39.318 -26.558 1.00 58.64  ? 1378 HOH A O   1 
HETATM 5008 O  O   . HOH M 9 .   ? 4.405   -62.228 -19.971 1.00 26.21  ? 1379 HOH A O   1 
HETATM 5009 O  O   . HOH M 9 .   ? -8.401  -67.836 -28.414 1.00 50.77  ? 1380 HOH A O   1 
HETATM 5010 O  O   . HOH M 9 .   ? 4.820   -68.707 -21.584 1.00 32.38  ? 1381 HOH A O   1 
HETATM 5011 O  O   . HOH M 9 .   ? 4.597   -7.418  -38.128 1.00 67.96  ? 1382 HOH A O   1 
HETATM 5012 O  O   . HOH M 9 .   ? -20.293 -57.244 -48.459 1.00 62.27  ? 1383 HOH A O   1 
HETATM 5013 O  O   . HOH M 9 .   ? -9.312  -39.097 -43.394 0.46 58.66  ? 1384 HOH A O   1 
HETATM 5014 O  O   . HOH M 9 .   ? -9.192  -35.000 -44.889 1.00 50.04  ? 1385 HOH A O   1 
HETATM 5015 O  O   . HOH M 9 .   ? -37.673 -60.564 -0.529  1.00 64.38  ? 1386 HOH A O   1 
HETATM 5016 O  O   . HOH M 9 .   ? -8.615  -30.832 -14.887 1.00 49.97  ? 1387 HOH A O   1 
HETATM 5017 O  O   . HOH M 9 .   ? -17.626 -28.143 -44.417 1.00 49.90  ? 1388 HOH A O   1 
HETATM 5018 O  O   . HOH M 9 .   ? -32.067 -13.737 -9.500  1.00 52.64  ? 1389 HOH A O   1 
HETATM 5019 O  O   . HOH M 9 .   ? -3.037  -55.455 -28.930 1.00 34.46  ? 1390 HOH A O   1 
HETATM 5020 O  O   . HOH M 9 .   ? -17.873 -46.896 -15.098 1.00 35.10  ? 1391 HOH A O   1 
HETATM 5021 O  O   . HOH M 9 .   ? -0.048  -45.914 -43.257 1.00 50.30  ? 1392 HOH A O   1 
HETATM 5022 O  O   . HOH M 9 .   ? -38.006 -51.233 -3.966  1.00 53.16  ? 1393 HOH A O   1 
HETATM 5023 O  O   . HOH M 9 .   ? -6.875  -73.840 -13.634 1.00 59.93  ? 1394 HOH A O   1 
HETATM 5024 O  O   . HOH M 9 .   ? -10.366 -17.305 -40.424 1.00 50.51  ? 1395 HOH A O   1 
HETATM 5025 O  O   . HOH M 9 .   ? -16.323 -48.943 -16.292 1.00 30.42  ? 1396 HOH A O   1 
HETATM 5026 O  O   . HOH M 9 .   ? -12.931 -21.954 15.143  1.00 55.21  ? 1397 HOH A O   1 
HETATM 5027 O  O   . HOH M 9 .   ? -15.747 -41.347 -38.707 1.00 40.05  ? 1398 HOH A O   1 
HETATM 5028 O  O   . HOH M 9 .   ? 4.921   -32.000 -15.075 0.26 18.63  ? 1399 HOH A O   1 
HETATM 5029 O  O   . HOH M 9 .   ? -40.747 -62.153 -3.182  1.00 62.02  ? 1400 HOH A O   1 
HETATM 5030 O  O   . HOH M 9 .   ? -36.869 -64.580 -0.002  1.00 43.96  ? 1401 HOH A O   1 
HETATM 5031 O  O   . HOH M 9 .   ? -26.871 -32.046 -14.279 0.26 47.11  ? 1402 HOH A O   1 
HETATM 5032 O  O   . HOH M 9 .   ? -34.456 -48.777 -20.726 1.00 58.12  ? 1403 HOH A O   1 
HETATM 5033 O  O   . HOH M 9 .   ? 8.320   -35.841 -14.474 0.26 17.48  ? 1404 HOH A O   1 
HETATM 5034 O  O   . HOH M 9 .   ? -12.694 -74.906 -26.438 1.00 70.31  ? 1405 HOH A O   1 
HETATM 5035 O  O   . HOH M 9 .   ? -3.408  -51.901 -5.019  1.00 57.27  ? 1406 HOH A O   1 
HETATM 5036 O  O   . HOH M 9 .   ? -19.086 -13.472 -38.734 1.00 72.50  ? 1407 HOH A O   1 
HETATM 5037 O  O   . HOH M 9 .   ? -7.194  -44.946 -16.892 1.00 65.16  ? 1408 HOH A O   1 
HETATM 5038 O  O   . HOH M 9 .   ? -7.162  -29.536 -13.251 1.00 62.49  ? 1409 HOH A O   1 
HETATM 5039 O  O   . HOH M 9 .   ? -42.386 -66.225 -10.024 1.00 53.89  ? 1410 HOH A O   1 
HETATM 5040 O  O   . HOH M 9 .   ? -15.814 -68.840 -6.067  1.00 36.23  ? 1411 HOH A O   1 
HETATM 5041 O  O   . HOH M 9 .   ? -10.230 -39.424 -40.741 0.50 28.44  ? 1412 HOH A O   1 
HETATM 5042 O  O   . HOH M 9 .   ? -22.275 -16.555 -38.800 1.00 58.76  ? 1413 HOH A O   1 
HETATM 5043 O  O   . HOH M 9 .   ? -15.440 -45.523 -19.277 1.00 44.22  ? 1414 HOH A O   1 
HETATM 5044 O  O   . HOH M 9 .   ? -34.699 -70.289 -13.800 1.00 59.93  ? 1415 HOH A O   1 
HETATM 5045 O  O   . HOH M 9 .   ? -15.154 -68.557 -20.399 0.50 53.61  ? 1416 HOH A O   1 
HETATM 5046 O  O   . HOH M 9 .   ? -14.183 -44.381 -10.048 1.00 65.53  ? 1417 HOH A O   1 
HETATM 5047 O  O   . HOH M 9 .   ? -9.901  -32.848 -45.743 1.00 68.85  ? 1418 HOH A O   1 
HETATM 5048 O  O   . HOH M 9 .   ? -33.916 -48.338 -10.052 0.50 44.05  ? 1419 HOH A O   1 
HETATM 5049 O  O   . HOH M 9 .   ? -1.462  -54.026 -1.032  1.00 53.66  ? 1420 HOH A O   1 
HETATM 5050 O  O   . HOH M 9 .   ? -34.648 -70.025 -9.509  1.00 60.67  ? 1421 HOH A O   1 
HETATM 5051 O  O   . HOH M 9 .   ? 0.000   -57.890 -28.721 0.50 32.11  ? 1422 HOH A O   1 
HETATM 5052 O  O   . HOH M 9 .   ? -25.638 -20.807 -4.900  1.00 53.99  ? 1423 HOH A O   1 
HETATM 5053 O  O   . HOH M 9 .   ? 0.000   -57.890 -15.951 0.50 42.84  ? 1424 HOH A O   1 
HETATM 5054 O  O   . HOH M 9 .   ? -21.370 -43.603 -42.037 1.00 62.64  ? 1425 HOH A O   1 
HETATM 5055 O  O   . HOH M 9 .   ? -41.387 -22.444 -18.087 1.00 76.10  ? 1426 HOH A O   1 
HETATM 5056 O  O   . HOH M 9 .   ? -5.332  -64.783 -30.973 1.00 54.72  ? 1427 HOH A O   1 
HETATM 5057 O  O   . HOH M 9 .   ? -36.268 -56.437 -4.427  1.00 57.00  ? 1428 HOH A O   1 
HETATM 5058 O  O   . HOH M 9 .   ? -31.015 -17.760 -5.967  1.00 66.09  ? 1429 HOH A O   1 
HETATM 5059 O  O   . HOH M 9 .   ? -29.003 -68.988 -40.340 0.50 39.38  ? 1430 HOH A O   1 
HETATM 5060 O  O   . HOH M 9 .   ? -16.723 -39.010 -39.943 1.00 46.91  ? 1431 HOH A O   1 
HETATM 5061 O  O   . HOH M 9 .   ? 6.137   -27.272 -15.533 0.26 27.49  ? 1432 HOH A O   1 
HETATM 5062 O  O   . HOH M 9 .   ? -30.656 -9.985  -36.724 1.00 57.09  ? 1433 HOH A O   1 
HETATM 5063 O  O   . HOH M 9 .   ? 0.452   -62.100 -17.488 1.00 39.65  ? 1434 HOH A O   1 
HETATM 5064 O  O   . HOH M 9 .   ? -12.770 -69.725 -25.221 1.00 72.43  ? 1435 HOH A O   1 
HETATM 5065 O  O   . HOH M 9 .   ? -41.429 -56.729 -13.754 1.00 42.21  ? 1436 HOH A O   1 
HETATM 5066 O  O   . HOH M 9 .   ? -23.531 -74.986 -14.143 1.00 60.50  ? 1437 HOH A O   1 
HETATM 5067 O  O   . HOH M 9 .   ? -2.594  -56.105 -33.879 1.00 62.19  ? 1438 HOH A O   1 
HETATM 5068 O  O   . HOH M 9 .   ? -35.683 -47.661 -14.251 1.00 55.88  ? 1439 HOH A O   1 
HETATM 5069 O  O   . HOH M 9 .   ? 16.746  -34.163 -26.455 1.00 52.92  ? 1440 HOH A O   1 
HETATM 5070 O  O   . HOH M 9 .   ? -19.931 -67.823 -4.130  1.00 34.84  ? 1441 HOH A O   1 
HETATM 5071 O  O   . HOH M 9 .   ? 12.457  -36.530 -30.885 1.00 61.46  ? 1442 HOH A O   1 
HETATM 5072 O  O   . HOH M 9 .   ? -25.788 -2.155  -29.086 1.00 56.36  ? 1443 HOH A O   1 
HETATM 5073 O  O   . HOH M 9 .   ? -9.423  -23.713 -3.649  1.00 65.85  ? 1444 HOH A O   1 
HETATM 5074 O  O   . HOH M 9 .   ? -13.817 -34.926 -44.473 0.46 38.15  ? 1445 HOH A O   1 
HETATM 5075 O  O   . HOH M 9 .   ? -2.818  -59.697 -6.073  1.00 65.52  ? 1446 HOH A O   1 
HETATM 5076 O  O   . HOH M 9 .   ? -32.235 -75.259 -7.381  1.00 67.49  ? 1447 HOH A O   1 
HETATM 5077 O  O   . HOH M 9 .   ? -19.519 -45.274 -18.720 1.00 66.53  ? 1448 HOH A O   1 
HETATM 5078 O  O   . HOH M 9 .   ? -18.337 -67.588 -6.357  1.00 26.50  ? 1449 HOH A O   1 
HETATM 5079 O  O   . HOH M 9 .   ? 0.772   -42.636 -21.915 1.00 55.93  ? 1450 HOH A O   1 
HETATM 5080 O  O   . HOH M 9 .   ? -15.687 -42.926 -23.916 1.00 52.02  ? 1451 HOH A O   1 
HETATM 5081 O  O   . HOH M 9 .   ? -5.324  -63.903 -6.596  1.00 51.56  ? 1452 HOH A O   1 
HETATM 5082 O  O   . HOH M 9 .   ? -2.625  -59.390 -0.409  1.00 60.52  ? 1453 HOH A O   1 
HETATM 5083 O  O   . HOH M 9 .   ? -32.468 -66.802 -23.246 1.00 70.80  ? 1454 HOH A O   1 
HETATM 5084 O  O   . HOH M 9 .   ? -44.437 -67.845 -15.415 1.00 59.78  ? 1455 HOH A O   1 
HETATM 5085 O  O   . HOH M 9 .   ? -30.853 -24.230 -3.084  1.00 78.22  ? 1456 HOH A O   1 
HETATM 5086 O  O   . HOH M 9 .   ? 13.240  -25.413 -27.033 1.00 57.31  ? 1457 HOH A O   1 
# 
