data_7I2E
# 
_entry.id   7I2E 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   7I2E         pdb_00007i2e 10.2210/pdb7i2e/pdb 
WWPDB D_1001408229 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-02 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.entry_id                        7I2E 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.recvd_initial_deposition_date   2025-03-06 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.SG_entry                        ? 
_pdbx_database_status.pdb_format_compatible           N 
_pdbx_database_status.methods_development_category    ? 
# 
_pdbx_contact_author.id                 1 
_pdbx_contact_author.email              fr193@cabm.rutgers.edu 
_pdbx_contact_author.name_first         'Francesc Xavier' 
_pdbx_contact_author.name_last          Ruiz 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0457-0030 
_pdbx_contact_author.name_mi            ? 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Aschenbrenner, J.C.' 1  ? 
'Saini, M.'           2  ? 
'Chopra, A.'          3  ? 
'Marples, P.G.'       4  ? 
'Balcomb, B.H.'       5  ? 
'Lithgo, R.M.'        6  ? 
'Fearon, D.'          7  ? 
'von Delft, F.'       8  ? 
'Ruiz, F.X.'          9  ? 
'Arnold, E.'          10 ? 
# 
_citation.id                        primary 
_citation.title                     
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_volume            ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.year                      ? 
_citation.journal_id_ASTM           ? 
_citation.country                   ? 
_citation.journal_id_ISSN           ? 
_citation.journal_id_CSD            0353 
_citation.book_publisher            ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_DOI      ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.identifier_ORCID 
_citation_author.ordinal 
primary 'Aschenbrenner, J.C.' ? 1  
primary 'Saini, M.'           ? 2  
primary 'Chopra, A.'          ? 3  
primary 'Marples, P.G.'       ? 4  
primary 'Balcomb, B.H.'       ? 5  
primary 'Lithgo, R.M.'        ? 6  
primary 'Fearon, D.'          ? 7  
primary 'von Delft, F.'       ? 8  
primary 'Ruiz, F.X.'          ? 9  
primary 'Arnold, E.'          ? 10 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'NS5 RNA-dependent RNA polymerase'                                    73890.008 1   ? ? ? ? 
2 non-polymer syn 'ZINC ION'                                                            65.409    2   ? ? ? ? 
3 non-polymer syn '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                                195.237   1   ? ? ? ? 
4 non-polymer syn 'DIMETHYL SULFOXIDE'                                                  78.133    2   ? ? ? ? 
5 non-polymer syn 'PHOSPHATE ION'                                                       94.971    2   ? ? ? ? 
6 non-polymer syn 'DI(HYDROXYETHYL)ETHER'                                               106.120   1   ? ? ? ? 
7 non-polymer syn 'N-[(1R)-1-(2,4-dimethyl-1,3-thiazol-5-yl)ethyl]-2-methylpropanamide' 226.338   1   ? ? ? ? 
8 non-polymer syn 'CHLORIDE ION'                                                        35.453    1   ? ? ? ? 
9 water       nat water                                                                 18.015    406 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION'                                                            ZN    
3 '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                                MES   
4 'DIMETHYL SULFOXIDE'                                                  DMS   
5 'PHOSPHATE ION'                                                       PO4   
6 'DI(HYDROXYETHYL)ETHER'                                               PEG   
7 'N-[(1R)-1-(2,4-dimethyl-1,3-thiazol-5-yl)ethyl]-2-methylpropanamide' A1BZQ 
8 'CHLORIDE ION'                                                        CL    
9 water                                                                 HOH   
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PRO n 
1 3   GLY n 
1 4   ILE n 
1 5   GLU n 
1 6   SER n 
1 7   GLU n 
1 8   THR n 
1 9   PRO n 
1 10  ASN n 
1 11  LEU n 
1 12  ASP n 
1 13  ILE n 
1 14  ILE n 
1 15  GLY n 
1 16  LYS n 
1 17  ARG n 
1 18  ILE n 
1 19  GLU n 
1 20  LYS n 
1 21  ILE n 
1 22  LYS n 
1 23  GLN n 
1 24  GLU n 
1 25  HIS n 
1 26  GLU n 
1 27  THR n 
1 28  SER n 
1 29  TRP n 
1 30  HIS n 
1 31  TYR n 
1 32  ASP n 
1 33  GLN n 
1 34  ASP n 
1 35  HIS n 
1 36  PRO n 
1 37  TYR n 
1 38  LYS n 
1 39  THR n 
1 40  TRP n 
1 41  ALA n 
1 42  TYR n 
1 43  HIS n 
1 44  GLY n 
1 45  SER n 
1 46  TYR n 
1 47  GLU n 
1 48  THR n 
1 49  LYS n 
1 50  GLN n 
1 51  THR n 
1 52  GLY n 
1 53  SER n 
1 54  ALA n 
1 55  SER n 
1 56  SER n 
1 57  MET n 
1 58  VAL n 
1 59  ASN n 
1 60  GLY n 
1 61  VAL n 
1 62  VAL n 
1 63  ARG n 
1 64  LEU n 
1 65  LEU n 
1 66  THR n 
1 67  LYS n 
1 68  PRO n 
1 69  TRP n 
1 70  ASP n 
1 71  ILE n 
1 72  ILE n 
1 73  PRO n 
1 74  MET n 
1 75  VAL n 
1 76  THR n 
1 77  GLN n 
1 78  MET n 
1 79  ALA n 
1 80  MET n 
1 81  THR n 
1 82  ASP n 
1 83  THR n 
1 84  THR n 
1 85  PRO n 
1 86  PHE n 
1 87  GLY n 
1 88  GLN n 
1 89  GLN n 
1 90  ARG n 
1 91  VAL n 
1 92  PHE n 
1 93  LYS n 
1 94  GLU n 
1 95  LYS n 
1 96  VAL n 
1 97  ASP n 
1 98  THR n 
1 99  ARG n 
1 100 THR n 
1 101 GLN n 
1 102 GLU n 
1 103 PRO n 
1 104 LYS n 
1 105 GLU n 
1 106 GLY n 
1 107 THR n 
1 108 LYS n 
1 109 LYS n 
1 110 LEU n 
1 111 MET n 
1 112 LYS n 
1 113 ILE n 
1 114 THR n 
1 115 ALA n 
1 116 GLU n 
1 117 TRP n 
1 118 LEU n 
1 119 TRP n 
1 120 LYS n 
1 121 GLU n 
1 122 LEU n 
1 123 GLY n 
1 124 LYS n 
1 125 LYS n 
1 126 LYS n 
1 127 THR n 
1 128 PRO n 
1 129 ARG n 
1 130 MET n 
1 131 CYS n 
1 132 THR n 
1 133 ARG n 
1 134 GLU n 
1 135 GLU n 
1 136 PHE n 
1 137 THR n 
1 138 ARG n 
1 139 LYS n 
1 140 VAL n 
1 141 ARG n 
1 142 SER n 
1 143 ASN n 
1 144 ALA n 
1 145 ALA n 
1 146 LEU n 
1 147 GLY n 
1 148 ALA n 
1 149 ILE n 
1 150 PHE n 
1 151 THR n 
1 152 ASP n 
1 153 GLU n 
1 154 ASN n 
1 155 LYS n 
1 156 TRP n 
1 157 LYS n 
1 158 SER n 
1 159 ALA n 
1 160 ARG n 
1 161 GLU n 
1 162 ALA n 
1 163 VAL n 
1 164 GLU n 
1 165 ASP n 
1 166 SER n 
1 167 GLY n 
1 168 PHE n 
1 169 TRP n 
1 170 GLU n 
1 171 LEU n 
1 172 VAL n 
1 173 ASP n 
1 174 LYS n 
1 175 GLU n 
1 176 ARG n 
1 177 ASN n 
1 178 LEU n 
1 179 HIS n 
1 180 LEU n 
1 181 GLU n 
1 182 GLY n 
1 183 LYS n 
1 184 CYS n 
1 185 GLU n 
1 186 THR n 
1 187 CYS n 
1 188 VAL n 
1 189 TYR n 
1 190 ASN n 
1 191 MET n 
1 192 MET n 
1 193 GLY n 
1 194 LYS n 
1 195 ARG n 
1 196 GLU n 
1 197 LYS n 
1 198 LYS n 
1 199 LEU n 
1 200 GLY n 
1 201 GLU n 
1 202 PHE n 
1 203 GLY n 
1 204 LYS n 
1 205 ALA n 
1 206 LYS n 
1 207 GLY n 
1 208 SER n 
1 209 ARG n 
1 210 ALA n 
1 211 ILE n 
1 212 TRP n 
1 213 TYR n 
1 214 MET n 
1 215 TRP n 
1 216 LEU n 
1 217 GLY n 
1 218 ALA n 
1 219 ARG n 
1 220 PHE n 
1 221 LEU n 
1 222 GLU n 
1 223 PHE n 
1 224 GLU n 
1 225 ALA n 
1 226 LEU n 
1 227 GLY n 
1 228 PHE n 
1 229 LEU n 
1 230 ASN n 
1 231 GLU n 
1 232 ASP n 
1 233 HIS n 
1 234 TRP n 
1 235 PHE n 
1 236 SER n 
1 237 ARG n 
1 238 GLU n 
1 239 ASN n 
1 240 SER n 
1 241 LEU n 
1 242 SER n 
1 243 GLY n 
1 244 VAL n 
1 245 GLU n 
1 246 GLY n 
1 247 GLU n 
1 248 GLY n 
1 249 LEU n 
1 250 HIS n 
1 251 LYS n 
1 252 LEU n 
1 253 GLY n 
1 254 TYR n 
1 255 ILE n 
1 256 LEU n 
1 257 ARG n 
1 258 ASP n 
1 259 VAL n 
1 260 SER n 
1 261 LYS n 
1 262 LYS n 
1 263 GLU n 
1 264 GLY n 
1 265 GLY n 
1 266 ALA n 
1 267 MET n 
1 268 TYR n 
1 269 ALA n 
1 270 ASP n 
1 271 ASP n 
1 272 THR n 
1 273 ALA n 
1 274 GLY n 
1 275 TRP n 
1 276 ASP n 
1 277 THR n 
1 278 ARG n 
1 279 ILE n 
1 280 THR n 
1 281 LEU n 
1 282 GLU n 
1 283 ASP n 
1 284 LEU n 
1 285 LYS n 
1 286 ASN n 
1 287 GLU n 
1 288 GLU n 
1 289 MET n 
1 290 VAL n 
1 291 THR n 
1 292 ASN n 
1 293 HIS n 
1 294 MET n 
1 295 GLU n 
1 296 GLY n 
1 297 GLU n 
1 298 HIS n 
1 299 LYS n 
1 300 LYS n 
1 301 LEU n 
1 302 ALA n 
1 303 GLU n 
1 304 ALA n 
1 305 ILE n 
1 306 PHE n 
1 307 LYS n 
1 308 LEU n 
1 309 THR n 
1 310 TYR n 
1 311 GLN n 
1 312 ASN n 
1 313 LYS n 
1 314 VAL n 
1 315 VAL n 
1 316 ARG n 
1 317 VAL n 
1 318 GLN n 
1 319 ARG n 
1 320 PRO n 
1 321 THR n 
1 322 PRO n 
1 323 ARG n 
1 324 GLY n 
1 325 THR n 
1 326 VAL n 
1 327 MET n 
1 328 ASP n 
1 329 ILE n 
1 330 ILE n 
1 331 SER n 
1 332 ARG n 
1 333 ARG n 
1 334 ASP n 
1 335 GLN n 
1 336 ARG n 
1 337 GLY n 
1 338 SER n 
1 339 GLY n 
1 340 GLN n 
1 341 VAL n 
1 342 VAL n 
1 343 THR n 
1 344 TYR n 
1 345 GLY n 
1 346 LEU n 
1 347 ASN n 
1 348 THR n 
1 349 PHE n 
1 350 THR n 
1 351 ASN n 
1 352 MET n 
1 353 GLU n 
1 354 ALA n 
1 355 GLN n 
1 356 LEU n 
1 357 ILE n 
1 358 ARG n 
1 359 GLN n 
1 360 MET n 
1 361 GLU n 
1 362 GLY n 
1 363 GLU n 
1 364 GLY n 
1 365 VAL n 
1 366 PHE n 
1 367 LYS n 
1 368 SER n 
1 369 ILE n 
1 370 GLN n 
1 371 HIS n 
1 372 LEU n 
1 373 THR n 
1 374 VAL n 
1 375 THR n 
1 376 GLU n 
1 377 GLU n 
1 378 ILE n 
1 379 ALA n 
1 380 VAL n 
1 381 LYS n 
1 382 ASN n 
1 383 TRP n 
1 384 LEU n 
1 385 VAL n 
1 386 ARG n 
1 387 VAL n 
1 388 GLY n 
1 389 ARG n 
1 390 GLU n 
1 391 ARG n 
1 392 LEU n 
1 393 SER n 
1 394 ARG n 
1 395 MET n 
1 396 ALA n 
1 397 ILE n 
1 398 SER n 
1 399 GLY n 
1 400 ASP n 
1 401 ASP n 
1 402 CYS n 
1 403 VAL n 
1 404 VAL n 
1 405 LYS n 
1 406 PRO n 
1 407 LEU n 
1 408 ASP n 
1 409 ASP n 
1 410 ARG n 
1 411 PHE n 
1 412 ALA n 
1 413 SER n 
1 414 ALA n 
1 415 LEU n 
1 416 THR n 
1 417 ALA n 
1 418 LEU n 
1 419 ASN n 
1 420 ASP n 
1 421 MET n 
1 422 GLY n 
1 423 LYS n 
1 424 VAL n 
1 425 ARG n 
1 426 LYS n 
1 427 ASP n 
1 428 ILE n 
1 429 GLN n 
1 430 GLN n 
1 431 TRP n 
1 432 GLU n 
1 433 PRO n 
1 434 SER n 
1 435 ARG n 
1 436 GLY n 
1 437 TRP n 
1 438 ASN n 
1 439 ASP n 
1 440 TRP n 
1 441 THR n 
1 442 GLN n 
1 443 VAL n 
1 444 PRO n 
1 445 PHE n 
1 446 CYS n 
1 447 SER n 
1 448 HIS n 
1 449 HIS n 
1 450 PHE n 
1 451 HIS n 
1 452 GLU n 
1 453 LEU n 
1 454 ILE n 
1 455 MET n 
1 456 LYS n 
1 457 ASP n 
1 458 GLY n 
1 459 ARG n 
1 460 VAL n 
1 461 LEU n 
1 462 VAL n 
1 463 VAL n 
1 464 PRO n 
1 465 CYS n 
1 466 ARG n 
1 467 ASN n 
1 468 GLN n 
1 469 ASP n 
1 470 GLU n 
1 471 LEU n 
1 472 ILE n 
1 473 GLY n 
1 474 ARG n 
1 475 ALA n 
1 476 ARG n 
1 477 ILE n 
1 478 SER n 
1 479 GLN n 
1 480 GLY n 
1 481 ALA n 
1 482 GLY n 
1 483 TRP n 
1 484 SER n 
1 485 LEU n 
1 486 ARG n 
1 487 GLU n 
1 488 THR n 
1 489 ALA n 
1 490 CYS n 
1 491 LEU n 
1 492 GLY n 
1 493 LYS n 
1 494 SER n 
1 495 TYR n 
1 496 ALA n 
1 497 GLN n 
1 498 MET n 
1 499 TRP n 
1 500 SER n 
1 501 LEU n 
1 502 MET n 
1 503 TYR n 
1 504 PHE n 
1 505 HIS n 
1 506 ARG n 
1 507 ARG n 
1 508 ASP n 
1 509 LEU n 
1 510 ARG n 
1 511 LEU n 
1 512 ALA n 
1 513 ALA n 
1 514 ASN n 
1 515 ALA n 
1 516 ILE n 
1 517 CYS n 
1 518 SER n 
1 519 ALA n 
1 520 VAL n 
1 521 PRO n 
1 522 SER n 
1 523 HIS n 
1 524 TRP n 
1 525 VAL n 
1 526 PRO n 
1 527 THR n 
1 528 SER n 
1 529 ARG n 
1 530 THR n 
1 531 THR n 
1 532 TRP n 
1 533 SER n 
1 534 ILE n 
1 535 HIS n 
1 536 ALA n 
1 537 THR n 
1 538 HIS n 
1 539 GLU n 
1 540 TRP n 
1 541 MET n 
1 542 THR n 
1 543 THR n 
1 544 GLU n 
1 545 ASP n 
1 546 MET n 
1 547 LEU n 
1 548 THR n 
1 549 VAL n 
1 550 TRP n 
1 551 ASN n 
1 552 ARG n 
1 553 VAL n 
1 554 TRP n 
1 555 ILE n 
1 556 GLN n 
1 557 GLU n 
1 558 ASN n 
1 559 PRO n 
1 560 TRP n 
1 561 MET n 
1 562 GLU n 
1 563 ASP n 
1 564 LYS n 
1 565 THR n 
1 566 PRO n 
1 567 VAL n 
1 568 GLU n 
1 569 SER n 
1 570 TRP n 
1 571 GLU n 
1 572 GLU n 
1 573 ILE n 
1 574 PRO n 
1 575 TYR n 
1 576 LEU n 
1 577 GLY n 
1 578 LYS n 
1 579 ARG n 
1 580 GLU n 
1 581 ASP n 
1 582 GLN n 
1 583 TRP n 
1 584 CYS n 
1 585 GLY n 
1 586 SER n 
1 587 LEU n 
1 588 ILE n 
1 589 GLY n 
1 590 LEU n 
1 591 THR n 
1 592 SER n 
1 593 ARG n 
1 594 ALA n 
1 595 THR n 
1 596 TRP n 
1 597 ALA n 
1 598 LYS n 
1 599 ASN n 
1 600 ILE n 
1 601 GLN n 
1 602 THR n 
1 603 ALA n 
1 604 ILE n 
1 605 ASN n 
1 606 GLN n 
1 607 VAL n 
1 608 ARG n 
1 609 SER n 
1 610 LEU n 
1 611 ILE n 
1 612 GLY n 
1 613 ASN n 
1 614 GLU n 
1 615 GLU n 
1 616 TYR n 
1 617 THR n 
1 618 ASP n 
1 619 TYR n 
1 620 MET n 
1 621 PRO n 
1 622 SER n 
1 623 MET n 
1 624 LYS n 
1 625 ARG n 
1 626 PHE n 
1 627 ARG n 
1 628 ARG n 
1 629 GLU n 
1 630 GLU n 
1 631 GLU n 
1 632 GLU n 
1 633 ALA n 
1 634 GLY n 
1 635 VAL n 
1 636 LEU n 
1 637 TRP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   637 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'dengue virus type 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     11060 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
A1BZQ non-polymer         . 'N-[(1R)-1-(2,4-dimethyl-1,3-thiazol-5-yl)ethyl]-2-methylpropanamide' ? 'C11 H18 N2 O S' 226.338 
ALA   'L-peptide linking' y ALANINE                                                               ? 'C3 H7 N O2'     89.093  
ARG   'L-peptide linking' y ARGININE                                                              ? 'C6 H15 N4 O2 1' 175.209 
ASN   'L-peptide linking' y ASPARAGINE                                                            ? 'C4 H8 N2 O3'    132.118 
ASP   'L-peptide linking' y 'ASPARTIC ACID'                                                       ? 'C4 H7 N O4'     133.103 
CL    non-polymer         . 'CHLORIDE ION'                                                        ? 'Cl -1'          35.453  
CYS   'L-peptide linking' y CYSTEINE                                                              ? 'C3 H7 N O2 S'   121.158 
DMS   non-polymer         . 'DIMETHYL SULFOXIDE'                                                  ? 'C2 H6 O S'      78.133  
GLN   'L-peptide linking' y GLUTAMINE                                                             ? 'C5 H10 N2 O3'   146.144 
GLU   'L-peptide linking' y 'GLUTAMIC ACID'                                                       ? 'C5 H9 N O4'     147.129 
GLY   'peptide linking'   y GLYCINE                                                               ? 'C2 H5 N O2'     75.067  
HIS   'L-peptide linking' y HISTIDINE                                                             ? 'C6 H10 N3 O2 1' 156.162 
HOH   non-polymer         . WATER                                                                 ? 'H2 O'           18.015  
ILE   'L-peptide linking' y ISOLEUCINE                                                            ? 'C6 H13 N O2'    131.173 
LEU   'L-peptide linking' y LEUCINE                                                               ? 'C6 H13 N O2'    131.173 
LYS   'L-peptide linking' y LYSINE                                                                ? 'C6 H15 N2 O2 1' 147.195 
MES   non-polymer         . '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                                ? 'C6 H13 N O4 S'  195.237 
MET   'L-peptide linking' y METHIONINE                                                            ? 'C5 H11 N O2 S'  149.211 
PEG   non-polymer         . 'DI(HYDROXYETHYL)ETHER'                                               ? 'C4 H10 O3'      106.120 
PHE   'L-peptide linking' y PHENYLALANINE                                                         ? 'C9 H11 N O2'    165.189 
PO4   non-polymer         . 'PHOSPHATE ION'                                                       ? 'O4 P -3'        94.971  
PRO   'L-peptide linking' y PROLINE                                                               ? 'C5 H9 N O2'     115.130 
SER   'L-peptide linking' y SERINE                                                                ? 'C3 H7 N O3'     105.093 
THR   'L-peptide linking' y THREONINE                                                             ? 'C4 H9 N O3'     119.119 
TRP   'L-peptide linking' y TRYPTOPHAN                                                            ? 'C11 H12 N2 O2'  204.225 
TYR   'L-peptide linking' y TYROSINE                                                              ? 'C9 H11 N O3'    181.189 
VAL   'L-peptide linking' y VALINE                                                                ? 'C5 H11 N O2'    117.146 
ZN    non-polymer         . 'ZINC ION'                                                            ? 'Zn 2'           65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   264 ?   ?   ?   A . n 
A 1 2   PRO 2   265 ?   ?   ?   A . n 
A 1 3   GLY 3   266 ?   ?   ?   A . n 
A 1 4   ILE 4   267 ?   ?   ?   A . n 
A 1 5   GLU 5   268 ?   ?   ?   A . n 
A 1 6   SER 6   269 ?   ?   ?   A . n 
A 1 7   GLU 7   270 ?   ?   ?   A . n 
A 1 8   THR 8   271 ?   ?   ?   A . n 
A 1 9   PRO 9   272 ?   ?   ?   A . n 
A 1 10  ASN 10  273 273 ASN ASN A . n 
A 1 11  LEU 11  274 274 LEU LEU A . n 
A 1 12  ASP 12  275 275 ASP ASP A . n 
A 1 13  ILE 13  276 276 ILE ILE A . n 
A 1 14  ILE 14  277 277 ILE ILE A . n 
A 1 15  GLY 15  278 278 GLY GLY A . n 
A 1 16  LYS 16  279 279 LYS LYS A . n 
A 1 17  ARG 17  280 280 ARG ARG A . n 
A 1 18  ILE 18  281 281 ILE ILE A . n 
A 1 19  GLU 19  282 282 GLU GLU A . n 
A 1 20  LYS 20  283 283 LYS LYS A . n 
A 1 21  ILE 21  284 284 ILE ILE A . n 
A 1 22  LYS 22  285 285 LYS LYS A . n 
A 1 23  GLN 23  286 286 GLN GLN A . n 
A 1 24  GLU 24  287 287 GLU GLU A . n 
A 1 25  HIS 25  288 288 HIS HIS A . n 
A 1 26  GLU 26  289 289 GLU GLU A . n 
A 1 27  THR 27  290 290 THR THR A . n 
A 1 28  SER 28  291 291 SER SER A . n 
A 1 29  TRP 29  292 292 TRP TRP A . n 
A 1 30  HIS 30  293 293 HIS HIS A . n 
A 1 31  TYR 31  294 294 TYR TYR A . n 
A 1 32  ASP 32  295 295 ASP ASP A . n 
A 1 33  GLN 33  296 296 GLN GLN A . n 
A 1 34  ASP 34  297 297 ASP ASP A . n 
A 1 35  HIS 35  298 298 HIS HIS A . n 
A 1 36  PRO 36  299 299 PRO PRO A . n 
A 1 37  TYR 37  300 300 TYR TYR A . n 
A 1 38  LYS 38  301 301 LYS LYS A . n 
A 1 39  THR 39  302 302 THR THR A . n 
A 1 40  TRP 40  303 303 TRP TRP A . n 
A 1 41  ALA 41  304 304 ALA ALA A . n 
A 1 42  TYR 42  305 305 TYR TYR A . n 
A 1 43  HIS 43  306 306 HIS HIS A . n 
A 1 44  GLY 44  307 307 GLY GLY A . n 
A 1 45  SER 45  308 308 SER SER A . n 
A 1 46  TYR 46  309 309 TYR TYR A . n 
A 1 47  GLU 47  310 310 GLU GLU A . n 
A 1 48  THR 48  311 311 THR THR A . n 
A 1 49  LYS 49  312 312 LYS LYS A . n 
A 1 50  GLN 50  313 ?   ?   ?   A . n 
A 1 51  THR 51  314 ?   ?   ?   A . n 
A 1 52  GLY 52  315 ?   ?   ?   A . n 
A 1 53  SER 53  316 ?   ?   ?   A . n 
A 1 54  ALA 54  317 ?   ?   ?   A . n 
A 1 55  SER 55  318 318 SER SER A . n 
A 1 56  SER 56  319 319 SER SER A . n 
A 1 57  MET 57  320 320 MET MET A . n 
A 1 58  VAL 58  321 321 VAL VAL A . n 
A 1 59  ASN 59  322 322 ASN ASN A . n 
A 1 60  GLY 60  323 323 GLY GLY A . n 
A 1 61  VAL 61  324 324 VAL VAL A . n 
A 1 62  VAL 62  325 325 VAL VAL A . n 
A 1 63  ARG 63  326 326 ARG ARG A . n 
A 1 64  LEU 64  327 327 LEU LEU A . n 
A 1 65  LEU 65  328 328 LEU LEU A . n 
A 1 66  THR 66  329 329 THR THR A . n 
A 1 67  LYS 67  330 330 LYS LYS A . n 
A 1 68  PRO 68  331 331 PRO PRO A . n 
A 1 69  TRP 69  332 332 TRP TRP A . n 
A 1 70  ASP 70  333 333 ASP ASP A . n 
A 1 71  ILE 71  334 334 ILE ILE A . n 
A 1 72  ILE 72  335 335 ILE ILE A . n 
A 1 73  PRO 73  336 336 PRO PRO A . n 
A 1 74  MET 74  337 337 MET MET A . n 
A 1 75  VAL 75  338 338 VAL VAL A . n 
A 1 76  THR 76  339 339 THR THR A . n 
A 1 77  GLN 77  340 340 GLN GLN A . n 
A 1 78  MET 78  341 341 MET MET A . n 
A 1 79  ALA 79  342 342 ALA ALA A . n 
A 1 80  MET 80  343 343 MET MET A . n 
A 1 81  THR 81  344 344 THR GLY A . n 
A 1 82  ASP 82  345 ?   ?   ?   A . n 
A 1 83  THR 83  346 ?   ?   ?   A . n 
A 1 84  THR 84  347 ?   ?   ?   A . n 
A 1 85  PRO 85  348 ?   ?   ?   A . n 
A 1 86  PHE 86  349 ?   ?   ?   A . n 
A 1 87  GLY 87  350 ?   ?   ?   A . n 
A 1 88  GLN 88  351 ?   ?   ?   A . n 
A 1 89  GLN 89  352 ?   ?   ?   A . n 
A 1 90  ARG 90  353 ?   ?   ?   A . n 
A 1 91  VAL 91  354 ?   ?   ?   A . n 
A 1 92  PHE 92  355 ?   ?   ?   A . n 
A 1 93  LYS 93  356 356 LYS LYS A . n 
A 1 94  GLU 94  357 357 GLU GLU A . n 
A 1 95  LYS 95  358 358 LYS LYS A . n 
A 1 96  VAL 96  359 359 VAL VAL A . n 
A 1 97  ASP 97  360 360 ASP ASP A . n 
A 1 98  THR 98  361 361 THR THR A . n 
A 1 99  ARG 99  362 362 ARG ARG A . n 
A 1 100 THR 100 363 363 THR THR A . n 
A 1 101 GLN 101 364 364 GLN GLN A . n 
A 1 102 GLU 102 365 365 GLU GLU A . n 
A 1 103 PRO 103 366 366 PRO PRO A . n 
A 1 104 LYS 104 367 367 LYS LYS A . n 
A 1 105 GLU 105 368 368 GLU GLU A . n 
A 1 106 GLY 106 369 369 GLY GLY A . n 
A 1 107 THR 107 370 370 THR THR A . n 
A 1 108 LYS 108 371 371 LYS LYS A . n 
A 1 109 LYS 109 372 372 LYS LYS A . n 
A 1 110 LEU 110 373 373 LEU LEU A . n 
A 1 111 MET 111 374 374 MET MET A . n 
A 1 112 LYS 112 375 375 LYS LYS A . n 
A 1 113 ILE 113 376 376 ILE ILE A . n 
A 1 114 THR 114 377 377 THR THR A . n 
A 1 115 ALA 115 378 378 ALA ALA A . n 
A 1 116 GLU 116 379 379 GLU GLU A . n 
A 1 117 TRP 117 380 380 TRP TRP A . n 
A 1 118 LEU 118 381 381 LEU LEU A . n 
A 1 119 TRP 119 382 382 TRP TRP A . n 
A 1 120 LYS 120 383 383 LYS LYS A . n 
A 1 121 GLU 121 384 384 GLU GLU A . n 
A 1 122 LEU 122 385 385 LEU LEU A . n 
A 1 123 GLY 123 386 386 GLY GLY A . n 
A 1 124 LYS 124 387 387 LYS LYS A . n 
A 1 125 LYS 125 388 388 LYS LYS A . n 
A 1 126 LYS 126 389 389 LYS LYS A . n 
A 1 127 THR 127 390 390 THR THR A . n 
A 1 128 PRO 128 391 391 PRO PRO A . n 
A 1 129 ARG 129 392 392 ARG ARG A . n 
A 1 130 MET 130 393 393 MET MET A . n 
A 1 131 CYS 131 394 394 CYS CYS A . n 
A 1 132 THR 132 395 395 THR THR A . n 
A 1 133 ARG 133 396 396 ARG ARG A . n 
A 1 134 GLU 134 397 397 GLU GLU A . n 
A 1 135 GLU 135 398 398 GLU GLU A . n 
A 1 136 PHE 136 399 399 PHE PHE A . n 
A 1 137 THR 137 400 400 THR THR A . n 
A 1 138 ARG 138 401 401 ARG ARG A . n 
A 1 139 LYS 139 402 402 LYS LYS A . n 
A 1 140 VAL 140 403 403 VAL VAL A . n 
A 1 141 ARG 141 404 404 ARG ARG A . n 
A 1 142 SER 142 405 405 SER SER A . n 
A 1 143 ASN 143 406 406 ASN ASN A . n 
A 1 144 ALA 144 407 407 ALA ALA A . n 
A 1 145 ALA 145 408 408 ALA ALA A . n 
A 1 146 LEU 146 409 409 LEU LEU A . n 
A 1 147 GLY 147 410 410 GLY GLY A . n 
A 1 148 ALA 148 411 411 ALA ALA A . n 
A 1 149 ILE 149 412 412 ILE ILE A . n 
A 1 150 PHE 150 413 ?   ?   ?   A . n 
A 1 151 THR 151 414 ?   ?   ?   A . n 
A 1 152 ASP 152 415 ?   ?   ?   A . n 
A 1 153 GLU 153 416 ?   ?   ?   A . n 
A 1 154 ASN 154 417 ?   ?   ?   A . n 
A 1 155 LYS 155 418 418 LYS LYS A . n 
A 1 156 TRP 156 419 419 TRP TRP A . n 
A 1 157 LYS 157 420 420 LYS LYS A . n 
A 1 158 SER 158 421 421 SER SER A . n 
A 1 159 ALA 159 422 422 ALA ALA A . n 
A 1 160 ARG 160 423 423 ARG ARG A . n 
A 1 161 GLU 161 424 424 GLU GLU A . n 
A 1 162 ALA 162 425 425 ALA ALA A . n 
A 1 163 VAL 163 426 426 VAL VAL A . n 
A 1 164 GLU 164 427 427 GLU GLU A . n 
A 1 165 ASP 165 428 428 ASP ASP A . n 
A 1 166 SER 166 429 429 SER SER A . n 
A 1 167 GLY 167 430 430 GLY GLY A . n 
A 1 168 PHE 168 431 431 PHE PHE A . n 
A 1 169 TRP 169 432 432 TRP TRP A . n 
A 1 170 GLU 170 433 433 GLU GLU A . n 
A 1 171 LEU 171 434 434 LEU LEU A . n 
A 1 172 VAL 172 435 435 VAL VAL A . n 
A 1 173 ASP 173 436 436 ASP ASP A . n 
A 1 174 LYS 174 437 437 LYS LYS A . n 
A 1 175 GLU 175 438 438 GLU GLU A . n 
A 1 176 ARG 176 439 439 ARG ARG A . n 
A 1 177 ASN 177 440 440 ASN ASN A . n 
A 1 178 LEU 178 441 441 LEU LEU A . n 
A 1 179 HIS 179 442 442 HIS HIS A . n 
A 1 180 LEU 180 443 443 LEU LEU A . n 
A 1 181 GLU 181 444 444 GLU GLU A . n 
A 1 182 GLY 182 445 445 GLY GLY A . n 
A 1 183 LYS 183 446 446 LYS LYS A . n 
A 1 184 CYS 184 447 447 CYS CYS A . n 
A 1 185 GLU 185 448 448 GLU GLU A . n 
A 1 186 THR 186 449 449 THR THR A . n 
A 1 187 CYS 187 450 450 CYS CYS A . n 
A 1 188 VAL 188 451 451 VAL VAL A . n 
A 1 189 TYR 189 452 452 TYR TYR A . n 
A 1 190 ASN 190 453 453 ASN ASN A . n 
A 1 191 MET 191 454 454 MET MET A . n 
A 1 192 MET 192 455 455 MET MET A . n 
A 1 193 GLY 193 456 ?   ?   ?   A . n 
A 1 194 LYS 194 457 ?   ?   ?   A . n 
A 1 195 ARG 195 458 ?   ?   ?   A . n 
A 1 196 GLU 196 459 ?   ?   ?   A . n 
A 1 197 LYS 197 460 ?   ?   ?   A . n 
A 1 198 LYS 198 461 ?   ?   ?   A . n 
A 1 199 LEU 199 462 ?   ?   ?   A . n 
A 1 200 GLY 200 463 ?   ?   ?   A . n 
A 1 201 GLU 201 464 ?   ?   ?   A . n 
A 1 202 PHE 202 465 ?   ?   ?   A . n 
A 1 203 GLY 203 466 ?   ?   ?   A . n 
A 1 204 LYS 204 467 ?   ?   ?   A . n 
A 1 205 ALA 205 468 ?   ?   ?   A . n 
A 1 206 LYS 206 469 ?   ?   ?   A . n 
A 1 207 GLY 207 470 ?   ?   ?   A . n 
A 1 208 SER 208 471 ?   ?   ?   A . n 
A 1 209 ARG 209 472 ?   ?   ?   A . n 
A 1 210 ALA 210 473 473 ALA ALA A . n 
A 1 211 ILE 211 474 474 ILE ILE A . n 
A 1 212 TRP 212 475 475 TRP TRP A . n 
A 1 213 TYR 213 476 476 TYR TYR A . n 
A 1 214 MET 214 477 477 MET MET A . n 
A 1 215 TRP 215 478 478 TRP TRP A . n 
A 1 216 LEU 216 479 479 LEU LEU A . n 
A 1 217 GLY 217 480 480 GLY GLY A . n 
A 1 218 ALA 218 481 481 ALA ALA A . n 
A 1 219 ARG 219 482 482 ARG ARG A . n 
A 1 220 PHE 220 483 483 PHE PHE A . n 
A 1 221 LEU 221 484 484 LEU LEU A . n 
A 1 222 GLU 222 485 485 GLU GLU A . n 
A 1 223 PHE 223 486 486 PHE PHE A . n 
A 1 224 GLU 224 487 487 GLU GLU A . n 
A 1 225 ALA 225 488 488 ALA ALA A . n 
A 1 226 LEU 226 489 489 LEU LEU A . n 
A 1 227 GLY 227 490 490 GLY GLY A . n 
A 1 228 PHE 228 491 491 PHE PHE A . n 
A 1 229 LEU 229 492 492 LEU LEU A . n 
A 1 230 ASN 230 493 493 ASN ASN A . n 
A 1 231 GLU 231 494 494 GLU GLU A . n 
A 1 232 ASP 232 495 495 ASP ASP A . n 
A 1 233 HIS 233 496 496 HIS HIS A . n 
A 1 234 TRP 234 497 497 TRP TRP A . n 
A 1 235 PHE 235 498 498 PHE PHE A . n 
A 1 236 SER 236 499 499 SER SER A . n 
A 1 237 ARG 237 500 500 ARG ARG A . n 
A 1 238 GLU 238 501 501 GLU GLU A . n 
A 1 239 ASN 239 502 502 ASN ASN A . n 
A 1 240 SER 240 503 503 SER SER A . n 
A 1 241 LEU 241 504 504 LEU LEU A . n 
A 1 242 SER 242 505 505 SER SER A . n 
A 1 243 GLY 243 506 506 GLY GLY A . n 
A 1 244 VAL 244 507 507 VAL VAL A . n 
A 1 245 GLU 245 508 508 GLU GLU A . n 
A 1 246 GLY 246 509 509 GLY GLY A . n 
A 1 247 GLU 247 510 510 GLU GLU A . n 
A 1 248 GLY 248 511 511 GLY GLY A . n 
A 1 249 LEU 249 512 512 LEU LEU A . n 
A 1 250 HIS 250 513 513 HIS HIS A . n 
A 1 251 LYS 251 514 514 LYS LYS A . n 
A 1 252 LEU 252 515 515 LEU LEU A . n 
A 1 253 GLY 253 516 516 GLY GLY A . n 
A 1 254 TYR 254 517 517 TYR TYR A . n 
A 1 255 ILE 255 518 518 ILE ILE A . n 
A 1 256 LEU 256 519 519 LEU LEU A . n 
A 1 257 ARG 257 520 520 ARG ARG A . n 
A 1 258 ASP 258 521 521 ASP ASP A . n 
A 1 259 VAL 259 522 522 VAL VAL A . n 
A 1 260 SER 260 523 523 SER SER A . n 
A 1 261 LYS 261 524 524 LYS LYS A . n 
A 1 262 LYS 262 525 525 LYS LYS A . n 
A 1 263 GLU 263 526 526 GLU GLU A . n 
A 1 264 GLY 264 527 527 GLY GLY A . n 
A 1 265 GLY 265 528 528 GLY GLY A . n 
A 1 266 ALA 266 529 529 ALA ALA A . n 
A 1 267 MET 267 530 530 MET MET A . n 
A 1 268 TYR 268 531 531 TYR TYR A . n 
A 1 269 ALA 269 532 532 ALA ALA A . n 
A 1 270 ASP 270 533 533 ASP ASP A . n 
A 1 271 ASP 271 534 534 ASP ASP A . n 
A 1 272 THR 272 535 535 THR THR A . n 
A 1 273 ALA 273 536 536 ALA ALA A . n 
A 1 274 GLY 274 537 537 GLY GLY A . n 
A 1 275 TRP 275 538 538 TRP TRP A . n 
A 1 276 ASP 276 539 539 ASP ASP A . n 
A 1 277 THR 277 540 540 THR THR A . n 
A 1 278 ARG 278 541 541 ARG ARG A . n 
A 1 279 ILE 279 542 542 ILE ILE A . n 
A 1 280 THR 280 543 543 THR THR A . n 
A 1 281 LEU 281 544 544 LEU LEU A . n 
A 1 282 GLU 282 545 545 GLU GLU A . n 
A 1 283 ASP 283 546 546 ASP ASP A . n 
A 1 284 LEU 284 547 547 LEU LEU A . n 
A 1 285 LYS 285 548 548 LYS LYS A . n 
A 1 286 ASN 286 549 549 ASN ASN A . n 
A 1 287 GLU 287 550 550 GLU GLU A . n 
A 1 288 GLU 288 551 551 GLU GLU A . n 
A 1 289 MET 289 552 552 MET MET A . n 
A 1 290 VAL 290 553 553 VAL VAL A . n 
A 1 291 THR 291 554 554 THR THR A . n 
A 1 292 ASN 292 555 555 ASN ASN A . n 
A 1 293 HIS 293 556 556 HIS HIS A . n 
A 1 294 MET 294 557 557 MET MET A . n 
A 1 295 GLU 295 558 558 GLU GLU A . n 
A 1 296 GLY 296 559 559 GLY GLY A . n 
A 1 297 GLU 297 560 560 GLU GLU A . n 
A 1 298 HIS 298 561 561 HIS HIS A . n 
A 1 299 LYS 299 562 562 LYS LYS A . n 
A 1 300 LYS 300 563 563 LYS LYS A . n 
A 1 301 LEU 301 564 564 LEU LEU A . n 
A 1 302 ALA 302 565 565 ALA ALA A . n 
A 1 303 GLU 303 566 566 GLU GLU A . n 
A 1 304 ALA 304 567 567 ALA ALA A . n 
A 1 305 ILE 305 568 568 ILE ILE A . n 
A 1 306 PHE 306 569 569 PHE PHE A . n 
A 1 307 LYS 307 570 570 LYS LYS A . n 
A 1 308 LEU 308 571 571 LEU LEU A . n 
A 1 309 THR 309 572 572 THR THR A . n 
A 1 310 TYR 310 573 573 TYR TYR A . n 
A 1 311 GLN 311 574 574 GLN GLN A . n 
A 1 312 ASN 312 575 575 ASN ASN A . n 
A 1 313 LYS 313 576 576 LYS LYS A . n 
A 1 314 VAL 314 577 577 VAL VAL A . n 
A 1 315 VAL 315 578 578 VAL VAL A . n 
A 1 316 ARG 316 579 579 ARG ARG A . n 
A 1 317 VAL 317 580 580 VAL VAL A . n 
A 1 318 GLN 318 581 581 GLN GLN A . n 
A 1 319 ARG 319 582 582 ARG ARG A . n 
A 1 320 PRO 320 583 583 PRO PRO A . n 
A 1 321 THR 321 584 584 THR THR A . n 
A 1 322 PRO 322 585 ?   ?   ?   A . n 
A 1 323 ARG 323 586 ?   ?   ?   A . n 
A 1 324 GLY 324 587 ?   ?   ?   A . n 
A 1 325 THR 325 588 588 THR THR A . n 
A 1 326 VAL 326 589 589 VAL VAL A . n 
A 1 327 MET 327 590 590 MET MET A . n 
A 1 328 ASP 328 591 591 ASP ASP A . n 
A 1 329 ILE 329 592 592 ILE ILE A . n 
A 1 330 ILE 330 593 593 ILE ILE A . n 
A 1 331 SER 331 594 594 SER SER A . n 
A 1 332 ARG 332 595 595 ARG ARG A . n 
A 1 333 ARG 333 596 596 ARG ARG A . n 
A 1 334 ASP 334 597 597 ASP ASP A . n 
A 1 335 GLN 335 598 598 GLN GLN A . n 
A 1 336 ARG 336 599 599 ARG ARG A . n 
A 1 337 GLY 337 600 600 GLY GLY A . n 
A 1 338 SER 338 601 601 SER SER A . n 
A 1 339 GLY 339 602 602 GLY GLY A . n 
A 1 340 GLN 340 603 603 GLN GLN A . n 
A 1 341 VAL 341 604 604 VAL VAL A . n 
A 1 342 VAL 342 605 605 VAL VAL A . n 
A 1 343 THR 343 606 606 THR THR A . n 
A 1 344 TYR 344 607 607 TYR TYR A . n 
A 1 345 GLY 345 608 608 GLY GLY A . n 
A 1 346 LEU 346 609 609 LEU LEU A . n 
A 1 347 ASN 347 610 610 ASN ASN A . n 
A 1 348 THR 348 611 611 THR THR A . n 
A 1 349 PHE 349 612 612 PHE PHE A . n 
A 1 350 THR 350 613 613 THR THR A . n 
A 1 351 ASN 351 614 614 ASN ASN A . n 
A 1 352 MET 352 615 615 MET MET A . n 
A 1 353 GLU 353 616 616 GLU GLU A . n 
A 1 354 ALA 354 617 617 ALA ALA A . n 
A 1 355 GLN 355 618 618 GLN GLN A . n 
A 1 356 LEU 356 619 619 LEU LEU A . n 
A 1 357 ILE 357 620 620 ILE ILE A . n 
A 1 358 ARG 358 621 621 ARG ARG A . n 
A 1 359 GLN 359 622 622 GLN GLN A . n 
A 1 360 MET 360 623 623 MET MET A . n 
A 1 361 GLU 361 624 624 GLU GLU A . n 
A 1 362 GLY 362 625 625 GLY GLY A . n 
A 1 363 GLU 363 626 626 GLU GLU A . n 
A 1 364 GLY 364 627 627 GLY GLY A . n 
A 1 365 VAL 365 628 628 VAL VAL A . n 
A 1 366 PHE 366 629 629 PHE PHE A . n 
A 1 367 LYS 367 630 630 LYS LYS A . n 
A 1 368 SER 368 631 631 SER SER A . n 
A 1 369 ILE 369 632 632 ILE ILE A . n 
A 1 370 GLN 370 633 633 GLN GLN A . n 
A 1 371 HIS 371 634 634 HIS HIS A . n 
A 1 372 LEU 372 635 635 LEU LEU A . n 
A 1 373 THR 373 636 636 THR THR A . n 
A 1 374 VAL 374 637 637 VAL VAL A . n 
A 1 375 THR 375 638 638 THR THR A . n 
A 1 376 GLU 376 639 639 GLU GLU A . n 
A 1 377 GLU 377 640 640 GLU GLU A . n 
A 1 378 ILE 378 641 641 ILE ILE A . n 
A 1 379 ALA 379 642 642 ALA ALA A . n 
A 1 380 VAL 380 643 643 VAL VAL A . n 
A 1 381 LYS 381 644 644 LYS LYS A . n 
A 1 382 ASN 382 645 645 ASN ASN A . n 
A 1 383 TRP 383 646 646 TRP TRP A . n 
A 1 384 LEU 384 647 647 LEU LEU A . n 
A 1 385 VAL 385 648 648 VAL VAL A . n 
A 1 386 ARG 386 649 649 ARG ARG A . n 
A 1 387 VAL 387 650 650 VAL VAL A . n 
A 1 388 GLY 388 651 651 GLY GLY A . n 
A 1 389 ARG 389 652 652 ARG ARG A . n 
A 1 390 GLU 390 653 653 GLU GLU A . n 
A 1 391 ARG 391 654 654 ARG ARG A . n 
A 1 392 LEU 392 655 655 LEU LEU A . n 
A 1 393 SER 393 656 656 SER SER A . n 
A 1 394 ARG 394 657 657 ARG ARG A . n 
A 1 395 MET 395 658 658 MET MET A . n 
A 1 396 ALA 396 659 659 ALA ALA A . n 
A 1 397 ILE 397 660 660 ILE ILE A . n 
A 1 398 SER 398 661 661 SER SER A . n 
A 1 399 GLY 399 662 662 GLY GLY A . n 
A 1 400 ASP 400 663 663 ASP ASP A . n 
A 1 401 ASP 401 664 664 ASP ASP A . n 
A 1 402 CYS 402 665 665 CYS CYS A . n 
A 1 403 VAL 403 666 666 VAL VAL A . n 
A 1 404 VAL 404 667 667 VAL VAL A . n 
A 1 405 LYS 405 668 668 LYS LYS A . n 
A 1 406 PRO 406 669 669 PRO PRO A . n 
A 1 407 LEU 407 670 670 LEU LEU A . n 
A 1 408 ASP 408 671 671 ASP ASP A . n 
A 1 409 ASP 409 672 672 ASP ASP A . n 
A 1 410 ARG 410 673 673 ARG ARG A . n 
A 1 411 PHE 411 674 674 PHE PHE A . n 
A 1 412 ALA 412 675 675 ALA ALA A . n 
A 1 413 SER 413 676 676 SER SER A . n 
A 1 414 ALA 414 677 677 ALA ALA A . n 
A 1 415 LEU 415 678 678 LEU LEU A . n 
A 1 416 THR 416 679 679 THR THR A . n 
A 1 417 ALA 417 680 680 ALA ALA A . n 
A 1 418 LEU 418 681 681 LEU LEU A . n 
A 1 419 ASN 419 682 682 ASN ASN A . n 
A 1 420 ASP 420 683 683 ASP ASP A . n 
A 1 421 MET 421 684 684 MET MET A . n 
A 1 422 GLY 422 685 685 GLY GLY A . n 
A 1 423 LYS 423 686 686 LYS LYS A . n 
A 1 424 VAL 424 687 687 VAL VAL A . n 
A 1 425 ARG 425 688 688 ARG ARG A . n 
A 1 426 LYS 426 689 689 LYS LYS A . n 
A 1 427 ASP 427 690 690 ASP ASP A . n 
A 1 428 ILE 428 691 691 ILE ILE A . n 
A 1 429 GLN 429 692 692 GLN GLN A . n 
A 1 430 GLN 430 693 693 GLN GLN A . n 
A 1 431 TRP 431 694 694 TRP TRP A . n 
A 1 432 GLU 432 695 695 GLU GLU A . n 
A 1 433 PRO 433 696 696 PRO PRO A . n 
A 1 434 SER 434 697 697 SER SER A . n 
A 1 435 ARG 435 698 698 ARG ARG A . n 
A 1 436 GLY 436 699 699 GLY GLY A . n 
A 1 437 TRP 437 700 700 TRP TRP A . n 
A 1 438 ASN 438 701 701 ASN ASN A . n 
A 1 439 ASP 439 702 702 ASP ASP A . n 
A 1 440 TRP 440 703 703 TRP TRP A . n 
A 1 441 THR 441 704 704 THR THR A . n 
A 1 442 GLN 442 705 705 GLN GLN A . n 
A 1 443 VAL 443 706 706 VAL VAL A . n 
A 1 444 PRO 444 707 707 PRO PRO A . n 
A 1 445 PHE 445 708 708 PHE PHE A . n 
A 1 446 CYS 446 709 709 CYS CYS A . n 
A 1 447 SER 447 710 710 SER SER A . n 
A 1 448 HIS 448 711 711 HIS HIS A . n 
A 1 449 HIS 449 712 712 HIS HIS A . n 
A 1 450 PHE 450 713 713 PHE PHE A . n 
A 1 451 HIS 451 714 714 HIS HIS A . n 
A 1 452 GLU 452 715 715 GLU GLU A . n 
A 1 453 LEU 453 716 716 LEU LEU A . n 
A 1 454 ILE 454 717 717 ILE ILE A . n 
A 1 455 MET 455 718 718 MET MET A . n 
A 1 456 LYS 456 719 719 LYS LYS A . n 
A 1 457 ASP 457 720 720 ASP ASP A . n 
A 1 458 GLY 458 721 721 GLY GLY A . n 
A 1 459 ARG 459 722 722 ARG ARG A . n 
A 1 460 VAL 460 723 723 VAL VAL A . n 
A 1 461 LEU 461 724 724 LEU LEU A . n 
A 1 462 VAL 462 725 725 VAL VAL A . n 
A 1 463 VAL 463 726 726 VAL VAL A . n 
A 1 464 PRO 464 727 727 PRO PRO A . n 
A 1 465 CYS 465 728 728 CYS CYS A . n 
A 1 466 ARG 466 729 729 ARG ARG A . n 
A 1 467 ASN 467 730 730 ASN ASN A . n 
A 1 468 GLN 468 731 731 GLN GLN A . n 
A 1 469 ASP 469 732 732 ASP ASP A . n 
A 1 470 GLU 470 733 733 GLU GLU A . n 
A 1 471 LEU 471 734 734 LEU LEU A . n 
A 1 472 ILE 472 735 735 ILE ILE A . n 
A 1 473 GLY 473 736 736 GLY GLY A . n 
A 1 474 ARG 474 737 737 ARG ARG A . n 
A 1 475 ALA 475 738 738 ALA ALA A . n 
A 1 476 ARG 476 739 739 ARG ARG A . n 
A 1 477 ILE 477 740 740 ILE ILE A . n 
A 1 478 SER 478 741 741 SER SER A . n 
A 1 479 GLN 479 742 742 GLN GLN A . n 
A 1 480 GLY 480 743 743 GLY GLY A . n 
A 1 481 ALA 481 744 744 ALA ALA A . n 
A 1 482 GLY 482 745 745 GLY GLY A . n 
A 1 483 TRP 483 746 746 TRP TRP A . n 
A 1 484 SER 484 747 747 SER SER A . n 
A 1 485 LEU 485 748 748 LEU LEU A . n 
A 1 486 ARG 486 749 749 ARG ARG A . n 
A 1 487 GLU 487 750 750 GLU GLU A . n 
A 1 488 THR 488 751 751 THR THR A . n 
A 1 489 ALA 489 752 752 ALA ALA A . n 
A 1 490 CYS 490 753 753 CYS CYS A . n 
A 1 491 LEU 491 754 754 LEU LEU A . n 
A 1 492 GLY 492 755 755 GLY GLY A . n 
A 1 493 LYS 493 756 756 LYS LYS A . n 
A 1 494 SER 494 757 757 SER SER A . n 
A 1 495 TYR 495 758 758 TYR TYR A . n 
A 1 496 ALA 496 759 759 ALA ALA A . n 
A 1 497 GLN 497 760 760 GLN GLN A . n 
A 1 498 MET 498 761 761 MET MET A . n 
A 1 499 TRP 499 762 762 TRP TRP A . n 
A 1 500 SER 500 763 763 SER SER A . n 
A 1 501 LEU 501 764 764 LEU LEU A . n 
A 1 502 MET 502 765 765 MET MET A . n 
A 1 503 TYR 503 766 766 TYR TYR A . n 
A 1 504 PHE 504 767 767 PHE PHE A . n 
A 1 505 HIS 505 768 768 HIS HIS A . n 
A 1 506 ARG 506 769 769 ARG ARG A . n 
A 1 507 ARG 507 770 770 ARG ARG A . n 
A 1 508 ASP 508 771 771 ASP ASP A . n 
A 1 509 LEU 509 772 772 LEU LEU A . n 
A 1 510 ARG 510 773 773 ARG ARG A . n 
A 1 511 LEU 511 774 774 LEU LEU A . n 
A 1 512 ALA 512 775 775 ALA ALA A . n 
A 1 513 ALA 513 776 776 ALA ALA A . n 
A 1 514 ASN 514 777 777 ASN ASN A . n 
A 1 515 ALA 515 778 778 ALA ALA A . n 
A 1 516 ILE 516 779 779 ILE ILE A . n 
A 1 517 CYS 517 780 780 CYS CYS A . n 
A 1 518 SER 518 781 781 SER SER A . n 
A 1 519 ALA 519 782 782 ALA ALA A . n 
A 1 520 VAL 520 783 783 VAL VAL A . n 
A 1 521 PRO 521 784 784 PRO PRO A . n 
A 1 522 SER 522 785 785 SER SER A . n 
A 1 523 HIS 523 786 786 HIS HIS A . n 
A 1 524 TRP 524 787 787 TRP TRP A . n 
A 1 525 VAL 525 788 788 VAL VAL A . n 
A 1 526 PRO 526 789 789 PRO PRO A . n 
A 1 527 THR 527 790 790 THR THR A . n 
A 1 528 SER 528 791 791 SER SER A . n 
A 1 529 ARG 529 792 792 ARG ARG A . n 
A 1 530 THR 530 793 ?   ?   ?   A . n 
A 1 531 THR 531 794 ?   ?   ?   A . n 
A 1 532 TRP 532 795 ?   ?   ?   A . n 
A 1 533 SER 533 796 ?   ?   ?   A . n 
A 1 534 ILE 534 797 ?   ?   ?   A . n 
A 1 535 HIS 535 798 798 HIS HIS A . n 
A 1 536 ALA 536 799 799 ALA ALA A . n 
A 1 537 THR 537 800 800 THR THR A . n 
A 1 538 HIS 538 801 801 HIS HIS A . n 
A 1 539 GLU 539 802 802 GLU GLU A . n 
A 1 540 TRP 540 803 803 TRP TRP A . n 
A 1 541 MET 541 804 804 MET MET A . n 
A 1 542 THR 542 805 805 THR THR A . n 
A 1 543 THR 543 806 806 THR THR A . n 
A 1 544 GLU 544 807 807 GLU GLU A . n 
A 1 545 ASP 545 808 808 ASP ASP A . n 
A 1 546 MET 546 809 809 MET MET A . n 
A 1 547 LEU 547 810 810 LEU LEU A . n 
A 1 548 THR 548 811 811 THR THR A . n 
A 1 549 VAL 549 812 812 VAL VAL A . n 
A 1 550 TRP 550 813 813 TRP TRP A . n 
A 1 551 ASN 551 814 814 ASN ASN A . n 
A 1 552 ARG 552 815 815 ARG ARG A . n 
A 1 553 VAL 553 816 816 VAL VAL A . n 
A 1 554 TRP 554 817 817 TRP TRP A . n 
A 1 555 ILE 555 818 818 ILE ILE A . n 
A 1 556 GLN 556 819 819 GLN GLN A . n 
A 1 557 GLU 557 820 820 GLU GLU A . n 
A 1 558 ASN 558 821 821 ASN ASN A . n 
A 1 559 PRO 559 822 822 PRO PRO A . n 
A 1 560 TRP 560 823 823 TRP TRP A . n 
A 1 561 MET 561 824 824 MET MET A . n 
A 1 562 GLU 562 825 825 GLU GLU A . n 
A 1 563 ASP 563 826 826 ASP ASP A . n 
A 1 564 LYS 564 827 827 LYS LYS A . n 
A 1 565 THR 565 828 828 THR THR A . n 
A 1 566 PRO 566 829 829 PRO PRO A . n 
A 1 567 VAL 567 830 830 VAL VAL A . n 
A 1 568 GLU 568 831 831 GLU GLU A . n 
A 1 569 SER 569 832 832 SER SER A . n 
A 1 570 TRP 570 833 833 TRP TRP A . n 
A 1 571 GLU 571 834 834 GLU GLU A . n 
A 1 572 GLU 572 835 835 GLU GLU A . n 
A 1 573 ILE 573 836 836 ILE ILE A . n 
A 1 574 PRO 574 837 837 PRO PRO A . n 
A 1 575 TYR 575 838 838 TYR TYR A . n 
A 1 576 LEU 576 839 839 LEU LEU A . n 
A 1 577 GLY 577 840 840 GLY GLY A . n 
A 1 578 LYS 578 841 841 LYS LYS A . n 
A 1 579 ARG 579 842 842 ARG ARG A . n 
A 1 580 GLU 580 843 843 GLU GLU A . n 
A 1 581 ASP 581 844 844 ASP ASP A . n 
A 1 582 GLN 582 845 845 GLN GLN A . n 
A 1 583 TRP 583 846 846 TRP TRP A . n 
A 1 584 CYS 584 847 847 CYS CYS A . n 
A 1 585 GLY 585 848 848 GLY GLY A . n 
A 1 586 SER 586 849 849 SER SER A . n 
A 1 587 LEU 587 850 850 LEU LEU A . n 
A 1 588 ILE 588 851 851 ILE ILE A . n 
A 1 589 GLY 589 852 852 GLY GLY A . n 
A 1 590 LEU 590 853 853 LEU LEU A . n 
A 1 591 THR 591 854 854 THR THR A . n 
A 1 592 SER 592 855 855 SER SER A . n 
A 1 593 ARG 593 856 856 ARG ARG A . n 
A 1 594 ALA 594 857 857 ALA ALA A . n 
A 1 595 THR 595 858 858 THR THR A . n 
A 1 596 TRP 596 859 859 TRP TRP A . n 
A 1 597 ALA 597 860 860 ALA ALA A . n 
A 1 598 LYS 598 861 861 LYS LYS A . n 
A 1 599 ASN 599 862 862 ASN ASN A . n 
A 1 600 ILE 600 863 863 ILE ILE A . n 
A 1 601 GLN 601 864 864 GLN GLN A . n 
A 1 602 THR 602 865 865 THR THR A . n 
A 1 603 ALA 603 866 866 ALA ALA A . n 
A 1 604 ILE 604 867 867 ILE ILE A . n 
A 1 605 ASN 605 868 868 ASN ASN A . n 
A 1 606 GLN 606 869 869 GLN GLN A . n 
A 1 607 VAL 607 870 870 VAL VAL A . n 
A 1 608 ARG 608 871 871 ARG ARG A . n 
A 1 609 SER 609 872 872 SER SER A . n 
A 1 610 LEU 610 873 873 LEU LEU A . n 
A 1 611 ILE 611 874 874 ILE ILE A . n 
A 1 612 GLY 612 875 875 GLY GLY A . n 
A 1 613 ASN 613 876 876 ASN ASN A . n 
A 1 614 GLU 614 877 877 GLU GLU A . n 
A 1 615 GLU 615 878 878 GLU GLU A . n 
A 1 616 TYR 616 879 879 TYR TYR A . n 
A 1 617 THR 617 880 880 THR THR A . n 
A 1 618 ASP 618 881 881 ASP ASP A . n 
A 1 619 TYR 619 882 882 TYR TYR A . n 
A 1 620 MET 620 883 883 MET MET A . n 
A 1 621 PRO 621 884 884 PRO PRO A . n 
A 1 622 SER 622 885 885 SER SER A . n 
A 1 623 MET 623 886 886 MET MET A . n 
A 1 624 LYS 624 887 887 LYS LYS A . n 
A 1 625 ARG 625 888 888 ARG ARG A . n 
A 1 626 PHE 626 889 889 PHE PHE A . n 
A 1 627 ARG 627 890 890 ARG ARG A . n 
A 1 628 ARG 628 891 891 ARG ARG A . n 
A 1 629 GLU 629 892 ?   ?   ?   A . n 
A 1 630 GLU 630 893 ?   ?   ?   A . n 
A 1 631 GLU 631 894 ?   ?   ?   A . n 
A 1 632 GLU 632 895 ?   ?   ?   A . n 
A 1 633 ALA 633 896 ?   ?   ?   A . n 
A 1 634 GLY 634 897 ?   ?   ?   A . n 
A 1 635 VAL 635 898 ?   ?   ?   A . n 
A 1 636 LEU 636 899 ?   ?   ?   A . n 
A 1 637 TRP 637 900 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        A1BZQ 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   A1BZQ 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 ZN    1   1001 1001 ZN    ZN  A . 
C 2 ZN    1   1002 1002 ZN    ZN  A . 
D 3 MES   1   1003 1004 MES   MES A . 
E 4 DMS   1   1004 1530 DMS   DMS A . 
F 4 DMS   1   1005 1601 DMS   DMS A . 
G 5 PO4   1   1006 1604 PO4   PO4 A . 
H 5 PO4   1   1007 1606 PO4   PO4 A . 
I 6 PEG   1   1008 1607 PEG   PEG A . 
J 7 A1BZQ 1   1009 1801 A1BZQ LIG A . 
K 8 CL    1   1010 1    CL    CL  A . 
L 9 HOH   1   1101 259  HOH   HOH A . 
L 9 HOH   2   1102 58   HOH   HOH A . 
L 9 HOH   3   1103 341  HOH   HOH A . 
L 9 HOH   4   1104 85   HOH   HOH A . 
L 9 HOH   5   1105 189  HOH   HOH A . 
L 9 HOH   6   1106 11   HOH   HOH A . 
L 9 HOH   7   1107 273  HOH   HOH A . 
L 9 HOH   8   1108 35   HOH   HOH A . 
L 9 HOH   9   1109 52   HOH   HOH A . 
L 9 HOH   10  1110 267  HOH   HOH A . 
L 9 HOH   11  1111 149  HOH   HOH A . 
L 9 HOH   12  1112 195  HOH   HOH A . 
L 9 HOH   13  1113 191  HOH   HOH A . 
L 9 HOH   14  1114 250  HOH   HOH A . 
L 9 HOH   15  1115 230  HOH   HOH A . 
L 9 HOH   16  1116 214  HOH   HOH A . 
L 9 HOH   17  1117 76   HOH   HOH A . 
L 9 HOH   18  1118 153  HOH   HOH A . 
L 9 HOH   19  1119 34   HOH   HOH A . 
L 9 HOH   20  1120 120  HOH   HOH A . 
L 9 HOH   21  1121 185  HOH   HOH A . 
L 9 HOH   22  1122 92   HOH   HOH A . 
L 9 HOH   23  1123 460  HOH   HOH A . 
L 9 HOH   24  1124 310  HOH   HOH A . 
L 9 HOH   25  1125 202  HOH   HOH A . 
L 9 HOH   26  1126 152  HOH   HOH A . 
L 9 HOH   27  1127 396  HOH   HOH A . 
L 9 HOH   28  1128 16   HOH   HOH A . 
L 9 HOH   29  1129 251  HOH   HOH A . 
L 9 HOH   30  1130 216  HOH   HOH A . 
L 9 HOH   31  1131 176  HOH   HOH A . 
L 9 HOH   32  1132 209  HOH   HOH A . 
L 9 HOH   33  1133 252  HOH   HOH A . 
L 9 HOH   34  1134 249  HOH   HOH A . 
L 9 HOH   35  1135 201  HOH   HOH A . 
L 9 HOH   36  1136 227  HOH   HOH A . 
L 9 HOH   37  1137 148  HOH   HOH A . 
L 9 HOH   38  1138 204  HOH   HOH A . 
L 9 HOH   39  1139 348  HOH   HOH A . 
L 9 HOH   40  1140 268  HOH   HOH A . 
L 9 HOH   41  1141 70   HOH   HOH A . 
L 9 HOH   42  1142 303  HOH   HOH A . 
L 9 HOH   43  1143 319  HOH   HOH A . 
L 9 HOH   44  1144 166  HOH   HOH A . 
L 9 HOH   45  1145 180  HOH   HOH A . 
L 9 HOH   46  1146 174  HOH   HOH A . 
L 9 HOH   47  1147 243  HOH   HOH A . 
L 9 HOH   48  1148 179  HOH   HOH A . 
L 9 HOH   49  1149 206  HOH   HOH A . 
L 9 HOH   50  1150 31   HOH   HOH A . 
L 9 HOH   51  1151 190  HOH   HOH A . 
L 9 HOH   52  1152 196  HOH   HOH A . 
L 9 HOH   53  1153 211  HOH   HOH A . 
L 9 HOH   54  1154 363  HOH   HOH A . 
L 9 HOH   55  1155 458  HOH   HOH A . 
L 9 HOH   56  1156 3    HOH   HOH A . 
L 9 HOH   57  1157 197  HOH   HOH A . 
L 9 HOH   58  1158 217  HOH   HOH A . 
L 9 HOH   59  1159 25   HOH   HOH A . 
L 9 HOH   60  1160 205  HOH   HOH A . 
L 9 HOH   61  1161 184  HOH   HOH A . 
L 9 HOH   62  1162 2    HOH   HOH A . 
L 9 HOH   63  1163 226  HOH   HOH A . 
L 9 HOH   64  1164 280  HOH   HOH A . 
L 9 HOH   65  1165 294  HOH   HOH A . 
L 9 HOH   66  1166 215  HOH   HOH A . 
L 9 HOH   67  1167 199  HOH   HOH A . 
L 9 HOH   68  1168 276  HOH   HOH A . 
L 9 HOH   69  1169 178  HOH   HOH A . 
L 9 HOH   70  1170 395  HOH   HOH A . 
L 9 HOH   71  1171 187  HOH   HOH A . 
L 9 HOH   72  1172 89   HOH   HOH A . 
L 9 HOH   73  1173 165  HOH   HOH A . 
L 9 HOH   74  1174 177  HOH   HOH A . 
L 9 HOH   75  1175 264  HOH   HOH A . 
L 9 HOH   76  1176 277  HOH   HOH A . 
L 9 HOH   77  1177 218  HOH   HOH A . 
L 9 HOH   78  1178 292  HOH   HOH A . 
L 9 HOH   79  1179 188  HOH   HOH A . 
L 9 HOH   80  1180 7    HOH   HOH A . 
L 9 HOH   81  1181 234  HOH   HOH A . 
L 9 HOH   82  1182 96   HOH   HOH A . 
L 9 HOH   83  1183 167  HOH   HOH A . 
L 9 HOH   84  1184 99   HOH   HOH A . 
L 9 HOH   85  1185 210  HOH   HOH A . 
L 9 HOH   86  1186 274  HOH   HOH A . 
L 9 HOH   87  1187 300  HOH   HOH A . 
L 9 HOH   88  1188 117  HOH   HOH A . 
L 9 HOH   89  1189 222  HOH   HOH A . 
L 9 HOH   90  1190 122  HOH   HOH A . 
L 9 HOH   91  1191 288  HOH   HOH A . 
L 9 HOH   92  1192 392  HOH   HOH A . 
L 9 HOH   93  1193 207  HOH   HOH A . 
L 9 HOH   94  1194 345  HOH   HOH A . 
L 9 HOH   95  1195 327  HOH   HOH A . 
L 9 HOH   96  1196 69   HOH   HOH A . 
L 9 HOH   97  1197 240  HOH   HOH A . 
L 9 HOH   98  1198 296  HOH   HOH A . 
L 9 HOH   99  1199 119  HOH   HOH A . 
L 9 HOH   100 1200 306  HOH   HOH A . 
L 9 HOH   101 1201 236  HOH   HOH A . 
L 9 HOH   102 1202 285  HOH   HOH A . 
L 9 HOH   103 1203 19   HOH   HOH A . 
L 9 HOH   104 1204 223  HOH   HOH A . 
L 9 HOH   105 1205 232  HOH   HOH A . 
L 9 HOH   106 1206 26   HOH   HOH A . 
L 9 HOH   107 1207 266  HOH   HOH A . 
L 9 HOH   108 1208 256  HOH   HOH A . 
L 9 HOH   109 1209 186  HOH   HOH A . 
L 9 HOH   110 1210 312  HOH   HOH A . 
L 9 HOH   111 1211 265  HOH   HOH A . 
L 9 HOH   112 1212 183  HOH   HOH A . 
L 9 HOH   113 1213 281  HOH   HOH A . 
L 9 HOH   114 1214 220  HOH   HOH A . 
L 9 HOH   115 1215 198  HOH   HOH A . 
L 9 HOH   116 1216 291  HOH   HOH A . 
L 9 HOH   117 1217 6    HOH   HOH A . 
L 9 HOH   118 1218 225  HOH   HOH A . 
L 9 HOH   119 1219 151  HOH   HOH A . 
L 9 HOH   120 1220 325  HOH   HOH A . 
L 9 HOH   121 1221 245  HOH   HOH A . 
L 9 HOH   122 1222 356  HOH   HOH A . 
L 9 HOH   123 1223 45   HOH   HOH A . 
L 9 HOH   124 1224 257  HOH   HOH A . 
L 9 HOH   125 1225 328  HOH   HOH A . 
L 9 HOH   126 1226 279  HOH   HOH A . 
L 9 HOH   127 1227 333  HOH   HOH A . 
L 9 HOH   128 1228 5    HOH   HOH A . 
L 9 HOH   129 1229 47   HOH   HOH A . 
L 9 HOH   130 1230 311  HOH   HOH A . 
L 9 HOH   131 1231 194  HOH   HOH A . 
L 9 HOH   132 1232 231  HOH   HOH A . 
L 9 HOH   133 1233 244  HOH   HOH A . 
L 9 HOH   134 1234 213  HOH   HOH A . 
L 9 HOH   135 1235 125  HOH   HOH A . 
L 9 HOH   136 1236 247  HOH   HOH A . 
L 9 HOH   137 1237 182  HOH   HOH A . 
L 9 HOH   138 1238 272  HOH   HOH A . 
L 9 HOH   139 1239 305  HOH   HOH A . 
L 9 HOH   140 1240 10   HOH   HOH A . 
L 9 HOH   141 1241 289  HOH   HOH A . 
L 9 HOH   142 1242 309  HOH   HOH A . 
L 9 HOH   143 1243 342  HOH   HOH A . 
L 9 HOH   144 1244 307  HOH   HOH A . 
L 9 HOH   145 1245 150  HOH   HOH A . 
L 9 HOH   146 1246 308  HOH   HOH A . 
L 9 HOH   147 1247 323  HOH   HOH A . 
L 9 HOH   148 1248 304  HOH   HOH A . 
L 9 HOH   149 1249 238  HOH   HOH A . 
L 9 HOH   150 1250 400  HOH   HOH A . 
L 9 HOH   151 1251 254  HOH   HOH A . 
L 9 HOH   152 1252 318  HOH   HOH A . 
L 9 HOH   153 1253 293  HOH   HOH A . 
L 9 HOH   154 1254 260  HOH   HOH A . 
L 9 HOH   155 1255 97   HOH   HOH A . 
L 9 HOH   156 1256 224  HOH   HOH A . 
L 9 HOH   157 1257 235  HOH   HOH A . 
L 9 HOH   158 1258 290  HOH   HOH A . 
L 9 HOH   159 1259 346  HOH   HOH A . 
L 9 HOH   160 1260 219  HOH   HOH A . 
L 9 HOH   161 1261 278  HOH   HOH A . 
L 9 HOH   162 1262 127  HOH   HOH A . 
L 9 HOH   163 1263 161  HOH   HOH A . 
L 9 HOH   164 1264 358  HOH   HOH A . 
L 9 HOH   165 1265 30   HOH   HOH A . 
L 9 HOH   166 1266 336  HOH   HOH A . 
L 9 HOH   167 1267 369  HOH   HOH A . 
L 9 HOH   168 1268 320  HOH   HOH A . 
L 9 HOH   169 1269 261  HOH   HOH A . 
L 9 HOH   170 1270 39   HOH   HOH A . 
L 9 HOH   171 1271 298  HOH   HOH A . 
L 9 HOH   172 1272 228  HOH   HOH A . 
L 9 HOH   173 1273 275  HOH   HOH A . 
L 9 HOH   174 1274 262  HOH   HOH A . 
L 9 HOH   175 1275 246  HOH   HOH A . 
L 9 HOH   176 1276 29   HOH   HOH A . 
L 9 HOH   177 1277 313  HOH   HOH A . 
L 9 HOH   178 1278 322  HOH   HOH A . 
L 9 HOH   179 1279 233  HOH   HOH A . 
L 9 HOH   180 1280 271  HOH   HOH A . 
L 9 HOH   181 1281 4    HOH   HOH A . 
L 9 HOH   182 1282 315  HOH   HOH A . 
L 9 HOH   183 1283 212  HOH   HOH A . 
L 9 HOH   184 1284 331  HOH   HOH A . 
L 9 HOH   185 1285 368  HOH   HOH A . 
L 9 HOH   186 1286 270  HOH   HOH A . 
L 9 HOH   187 1287 15   HOH   HOH A . 
L 9 HOH   188 1288 160  HOH   HOH A . 
L 9 HOH   189 1289 339  HOH   HOH A . 
L 9 HOH   190 1290 144  HOH   HOH A . 
L 9 HOH   191 1291 321  HOH   HOH A . 
L 9 HOH   192 1292 326  HOH   HOH A . 
L 9 HOH   193 1293 22   HOH   HOH A . 
L 9 HOH   194 1294 329  HOH   HOH A . 
L 9 HOH   195 1295 355  HOH   HOH A . 
L 9 HOH   196 1296 357  HOH   HOH A . 
L 9 HOH   197 1297 241  HOH   HOH A . 
L 9 HOH   198 1298 221  HOH   HOH A . 
L 9 HOH   199 1299 378  HOH   HOH A . 
L 9 HOH   200 1300 389  HOH   HOH A . 
L 9 HOH   201 1301 377  HOH   HOH A . 
L 9 HOH   202 1302 350  HOH   HOH A . 
L 9 HOH   203 1303 27   HOH   HOH A . 
L 9 HOH   204 1304 401  HOH   HOH A . 
L 9 HOH   205 1305 38   HOH   HOH A . 
L 9 HOH   206 1306 104  HOH   HOH A . 
L 9 HOH   207 1307 330  HOH   HOH A . 
L 9 HOH   208 1308 110  HOH   HOH A . 
L 9 HOH   209 1309 367  HOH   HOH A . 
L 9 HOH   210 1310 344  HOH   HOH A . 
L 9 HOH   211 1311 286  HOH   HOH A . 
L 9 HOH   212 1312 284  HOH   HOH A . 
L 9 HOH   213 1313 302  HOH   HOH A . 
L 9 HOH   214 1314 297  HOH   HOH A . 
L 9 HOH   215 1315 175  HOH   HOH A . 
L 9 HOH   216 1316 143  HOH   HOH A . 
L 9 HOH   217 1317 282  HOH   HOH A . 
L 9 HOH   218 1318 388  HOH   HOH A . 
L 9 HOH   219 1319 131  HOH   HOH A . 
L 9 HOH   220 1320 349  HOH   HOH A . 
L 9 HOH   221 1321 316  HOH   HOH A . 
L 9 HOH   222 1322 338  HOH   HOH A . 
L 9 HOH   223 1323 335  HOH   HOH A . 
L 9 HOH   224 1324 352  HOH   HOH A . 
L 9 HOH   225 1325 371  HOH   HOH A . 
L 9 HOH   226 1326 170  HOH   HOH A . 
L 9 HOH   227 1327 386  HOH   HOH A . 
L 9 HOH   228 1328 366  HOH   HOH A . 
L 9 HOH   229 1329 46   HOH   HOH A . 
L 9 HOH   230 1330 237  HOH   HOH A . 
L 9 HOH   231 1331 379  HOH   HOH A . 
L 9 HOH   232 1332 462  HOH   HOH A . 
L 9 HOH   233 1333 353  HOH   HOH A . 
L 9 HOH   234 1334 255  HOH   HOH A . 
L 9 HOH   235 1335 384  HOH   HOH A . 
L 9 HOH   236 1336 203  HOH   HOH A . 
L 9 HOH   237 1337 362  HOH   HOH A . 
L 9 HOH   238 1338 365  HOH   HOH A . 
L 9 HOH   239 1339 33   HOH   HOH A . 
L 9 HOH   240 1340 380  HOH   HOH A . 
L 9 HOH   241 1341 405  HOH   HOH A . 
L 9 HOH   242 1342 364  HOH   HOH A . 
L 9 HOH   243 1343 376  HOH   HOH A . 
L 9 HOH   244 1344 334  HOH   HOH A . 
L 9 HOH   245 1345 1    HOH   HOH A . 
L 9 HOH   246 1346 361  HOH   HOH A . 
L 9 HOH   247 1347 40   HOH   HOH A . 
L 9 HOH   248 1348 324  HOH   HOH A . 
L 9 HOH   249 1349 351  HOH   HOH A . 
L 9 HOH   250 1350 347  HOH   HOH A . 
L 9 HOH   251 1351 372  HOH   HOH A . 
L 9 HOH   252 1352 381  HOH   HOH A . 
L 9 HOH   253 1353 42   HOH   HOH A . 
L 9 HOH   254 1354 14   HOH   HOH A . 
L 9 HOH   255 1355 374  HOH   HOH A . 
L 9 HOH   256 1356 109  HOH   HOH A . 
L 9 HOH   257 1357 399  HOH   HOH A . 
L 9 HOH   258 1358 383  HOH   HOH A . 
L 9 HOH   259 1359 314  HOH   HOH A . 
L 9 HOH   260 1360 62   HOH   HOH A . 
L 9 HOH   261 1361 299  HOH   HOH A . 
L 9 HOH   262 1362 394  HOH   HOH A . 
L 9 HOH   263 1363 402  HOH   HOH A . 
L 9 HOH   264 1364 28   HOH   HOH A . 
L 9 HOH   265 1365 118  HOH   HOH A . 
L 9 HOH   266 1366 406  HOH   HOH A . 
L 9 HOH   267 1367 91   HOH   HOH A . 
L 9 HOH   268 1368 398  HOH   HOH A . 
L 9 HOH   269 1369 82   HOH   HOH A . 
L 9 HOH   270 1370 263  HOH   HOH A . 
L 9 HOH   271 1371 24   HOH   HOH A . 
L 9 HOH   272 1372 136  HOH   HOH A . 
L 9 HOH   273 1373 391  HOH   HOH A . 
L 9 HOH   274 1374 57   HOH   HOH A . 
L 9 HOH   275 1375 56   HOH   HOH A . 
L 9 HOH   276 1376 418  HOH   HOH A . 
L 9 HOH   277 1377 393  HOH   HOH A . 
L 9 HOH   278 1378 83   HOH   HOH A . 
L 9 HOH   279 1379 404  HOH   HOH A . 
L 9 HOH   280 1380 411  HOH   HOH A . 
L 9 HOH   281 1381 32   HOH   HOH A . 
L 9 HOH   282 1382 142  HOH   HOH A . 
L 9 HOH   283 1383 248  HOH   HOH A . 
L 9 HOH   284 1384 340  HOH   HOH A . 
L 9 HOH   285 1385 137  HOH   HOH A . 
L 9 HOH   286 1386 208  HOH   HOH A . 
L 9 HOH   287 1387 283  HOH   HOH A . 
L 9 HOH   288 1388 67   HOH   HOH A . 
L 9 HOH   289 1389 132  HOH   HOH A . 
L 9 HOH   290 1390 114  HOH   HOH A . 
L 9 HOH   291 1391 354  HOH   HOH A . 
L 9 HOH   292 1392 13   HOH   HOH A . 
L 9 HOH   293 1393 359  HOH   HOH A . 
L 9 HOH   294 1394 373  HOH   HOH A . 
L 9 HOH   295 1395 101  HOH   HOH A . 
L 9 HOH   296 1396 375  HOH   HOH A . 
L 9 HOH   297 1397 193  HOH   HOH A . 
L 9 HOH   298 1398 98   HOH   HOH A . 
L 9 HOH   299 1399 390  HOH   HOH A . 
L 9 HOH   300 1400 403  HOH   HOH A . 
L 9 HOH   301 1401 387  HOH   HOH A . 
L 9 HOH   302 1402 422  HOH   HOH A . 
L 9 HOH   303 1403 431  HOH   HOH A . 
L 9 HOH   304 1404 412  HOH   HOH A . 
L 9 HOH   305 1405 287  HOH   HOH A . 
L 9 HOH   306 1406 421  HOH   HOH A . 
L 9 HOH   307 1407 416  HOH   HOH A . 
L 9 HOH   308 1408 100  HOH   HOH A . 
L 9 HOH   309 1409 48   HOH   HOH A . 
L 9 HOH   310 1410 115  HOH   HOH A . 
L 9 HOH   311 1411 459  HOH   HOH A . 
L 9 HOH   312 1412 124  HOH   HOH A . 
L 9 HOH   313 1413 269  HOH   HOH A . 
L 9 HOH   314 1414 50   HOH   HOH A . 
L 9 HOH   315 1415 410  HOH   HOH A . 
L 9 HOH   316 1416 80   HOH   HOH A . 
L 9 HOH   317 1417 454  HOH   HOH A . 
L 9 HOH   318 1418 23   HOH   HOH A . 
L 9 HOH   319 1419 415  HOH   HOH A . 
L 9 HOH   320 1420 43   HOH   HOH A . 
L 9 HOH   321 1421 65   HOH   HOH A . 
L 9 HOH   322 1422 111  HOH   HOH A . 
L 9 HOH   323 1423 78   HOH   HOH A . 
L 9 HOH   324 1424 332  HOH   HOH A . 
L 9 HOH   325 1425 413  HOH   HOH A . 
L 9 HOH   326 1426 439  HOH   HOH A . 
L 9 HOH   327 1427 59   HOH   HOH A . 
L 9 HOH   328 1428 360  HOH   HOH A . 
L 9 HOH   329 1429 129  HOH   HOH A . 
L 9 HOH   330 1430 438  HOH   HOH A . 
L 9 HOH   331 1431 451  HOH   HOH A . 
L 9 HOH   332 1432 444  HOH   HOH A . 
L 9 HOH   333 1433 382  HOH   HOH A . 
L 9 HOH   334 1434 385  HOH   HOH A . 
L 9 HOH   335 1435 253  HOH   HOH A . 
L 9 HOH   336 1436 200  HOH   HOH A . 
L 9 HOH   337 1437 436  HOH   HOH A . 
L 9 HOH   338 1438 63   HOH   HOH A . 
L 9 HOH   339 1439 452  HOH   HOH A . 
L 9 HOH   340 1440 414  HOH   HOH A . 
L 9 HOH   341 1441 429  HOH   HOH A . 
L 9 HOH   342 1442 427  HOH   HOH A . 
L 9 HOH   343 1443 18   HOH   HOH A . 
L 9 HOH   344 1444 128  HOH   HOH A . 
L 9 HOH   345 1445 430  HOH   HOH A . 
L 9 HOH   346 1446 12   HOH   HOH A . 
L 9 HOH   347 1447 75   HOH   HOH A . 
L 9 HOH   348 1448 409  HOH   HOH A . 
L 9 HOH   349 1449 337  HOH   HOH A . 
L 9 HOH   350 1450 157  HOH   HOH A . 
L 9 HOH   351 1451 20   HOH   HOH A . 
L 9 HOH   352 1452 428  HOH   HOH A . 
L 9 HOH   353 1453 425  HOH   HOH A . 
L 9 HOH   354 1454 239  HOH   HOH A . 
L 9 HOH   355 1455 61   HOH   HOH A . 
L 9 HOH   356 1456 397  HOH   HOH A . 
L 9 HOH   357 1457 54   HOH   HOH A . 
L 9 HOH   358 1458 456  HOH   HOH A . 
L 9 HOH   359 1459 424  HOH   HOH A . 
L 9 HOH   360 1460 134  HOH   HOH A . 
L 9 HOH   361 1461 407  HOH   HOH A . 
L 9 HOH   362 1462 53   HOH   HOH A . 
L 9 HOH   363 1463 434  HOH   HOH A . 
L 9 HOH   364 1464 301  HOH   HOH A . 
L 9 HOH   365 1465 169  HOH   HOH A . 
L 9 HOH   366 1466 94   HOH   HOH A . 
L 9 HOH   367 1467 102  HOH   HOH A . 
L 9 HOH   368 1468 426  HOH   HOH A . 
L 9 HOH   369 1469 442  HOH   HOH A . 
L 9 HOH   370 1470 432  HOH   HOH A . 
L 9 HOH   371 1471 437  HOH   HOH A . 
L 9 HOH   372 1472 435  HOH   HOH A . 
L 9 HOH   373 1473 51   HOH   HOH A . 
L 9 HOH   374 1474 172  HOH   HOH A . 
L 9 HOH   375 1475 123  HOH   HOH A . 
L 9 HOH   376 1476 141  HOH   HOH A . 
L 9 HOH   377 1477 88   HOH   HOH A . 
L 9 HOH   378 1478 423  HOH   HOH A . 
L 9 HOH   379 1479 44   HOH   HOH A . 
L 9 HOH   380 1480 464  HOH   HOH A . 
L 9 HOH   381 1481 433  HOH   HOH A . 
L 9 HOH   382 1482 443  HOH   HOH A . 
L 9 HOH   383 1483 8    HOH   HOH A . 
L 9 HOH   384 1484 168  HOH   HOH A . 
L 9 HOH   385 1485 445  HOH   HOH A . 
L 9 HOH   386 1486 74   HOH   HOH A . 
L 9 HOH   387 1487 55   HOH   HOH A . 
L 9 HOH   388 1488 121  HOH   HOH A . 
L 9 HOH   389 1489 126  HOH   HOH A . 
L 9 HOH   390 1490 447  HOH   HOH A . 
L 9 HOH   391 1491 449  HOH   HOH A . 
L 9 HOH   392 1492 441  HOH   HOH A . 
L 9 HOH   393 1493 463  HOH   HOH A . 
L 9 HOH   394 1494 420  HOH   HOH A . 
L 9 HOH   395 1495 9    HOH   HOH A . 
L 9 HOH   396 1496 135  HOH   HOH A . 
L 9 HOH   397 1497 49   HOH   HOH A . 
L 9 HOH   398 1498 448  HOH   HOH A . 
L 9 HOH   399 1499 440  HOH   HOH A . 
L 9 HOH   400 1500 173  HOH   HOH A . 
L 9 HOH   401 1501 95   HOH   HOH A . 
L 9 HOH   402 1502 417  HOH   HOH A . 
L 9 HOH   403 1503 130  HOH   HOH A . 
L 9 HOH   404 1504 17   HOH   HOH A . 
L 9 HOH   405 1505 73   HOH   HOH A . 
L 9 HOH   406 1506 450  HOH   HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A THR 344 ? CB  ? A THR 81 CB  
2 1 Y 1 A THR 344 ? OG1 ? A THR 81 OG1 
3 1 Y 1 A THR 344 ? CG2 ? A THR 81 CG2 
# 
loop_
_software.classification 
_software.name 
_software.version 
_software.citation_id 
_software.pdbx_ordinal 
refinement       REFMAC  5.8.0267 ? 1 
refinement       REFMAC5 .        ? 2 
'data scaling'   Aimless .        ? 3 
phasing          PHASER  .        ? 4 
'data reduction' XDS     .        ? 5 
# 
_cell.entry_id           7I2E 
_cell.length_a           82.492 
_cell.length_b           116.856 
_cell.length_c           148.924 
_cell.angle_alpha        90.00 
_cell.angle_beta         90.00 
_cell.angle_gamma        90.00 
_cell.Z_PDB              8 
_cell.pdbx_unique_axis   ? 
# 
_symmetry.entry_id                         7I2E 
_symmetry.space_group_name_H-M             'I 2 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                23 
# 
_exptl.entry_id          7I2E 
_exptl.method            'X-RAY DIFFRACTION' 
_exptl.crystals_number   1 
# 
_exptl_crystal.id                    1 
_exptl_crystal.density_meas          ? 
_exptl_crystal.density_Matthews      2.43 
_exptl_crystal.density_percent_sol   49.35 
_exptl_crystal.description           ? 
# 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.temp            293.15 
_exptl_crystal_grow.pdbx_details    '350 mM Magnesium chloride, 10% PEG 4000, 100 mM MES, pH 6.5' 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.pdbx_pH_range   ? 
# 
_diffrn.id                     1 
_diffrn.ambient_temp           100 
_diffrn.crystal_id             1 
_diffrn.ambient_temp_details   ? 
# 
_diffrn_detector.detector               PIXEL 
_diffrn_detector.type                   'DECTRIS EIGER2 XE 9M' 
_diffrn_detector.pdbx_collection_date   2023-08-09 
_diffrn_detector.diffrn_id              1 
_diffrn_detector.details                ? 
# 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.92124 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.diffrn_id                   1 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.type                        'DIAMOND BEAMLINE I04-1' 
_diffrn_source.pdbx_wavelength_list        0.92124 
_diffrn_source.pdbx_synchrotron_site       Diamond 
_diffrn_source.pdbx_synchrotron_beamline   I04-1 
_diffrn_source.pdbx_wavelength             ? 
# 
_reflns.entry_id                     7I2E 
_reflns.pdbx_diffrn_id               1 
_reflns.pdbx_ordinal                 1 
_reflns.d_resolution_low             74.50 
_reflns.d_resolution_high            1.72 
_reflns.number_obs                   76430 
_reflns.percent_possible_obs         99.8 
_reflns.pdbx_Rmerge_I_obs            0.153 
_reflns.pdbx_netI_over_sigmaI        10.0 
_reflns.pdbx_redundancy              13.6 
_reflns.pdbx_Rrim_I_all              0.158 
_reflns.pdbx_Rpim_I_all              0.043 
_reflns.pdbx_CC_half                 0.999 
_reflns.pdbx_number_measured_all     1037907 
_reflns.pdbx_chi_squared             0.42 
_reflns.observed_criterion_sigma_I   ? 
_reflns.observed_criterion_sigma_F   ? 
_reflns.number_all                   ? 
_reflns.pdbx_Rsym_value              ? 
_reflns.B_iso_Wilson_estimate        ? 
_reflns.pdbx_CC_star                 ? 
# 
_reflns_shell.pdbx_diffrn_id              1 
_reflns_shell.pdbx_ordinal                1 
_reflns_shell.d_res_high                  1.72 
_reflns_shell.d_res_low                   1.75 
_reflns_shell.number_measured_all         45330 
_reflns_shell.number_unique_obs           3861 
_reflns_shell.Rmerge_I_obs                5.001 
_reflns_shell.pdbx_chi_squared            0.16 
_reflns_shell.pdbx_redundancy             11.7 
_reflns_shell.percent_possible_obs        96.3 
_reflns_shell.pdbx_netI_over_sigmaI_obs   0.3 
_reflns_shell.pdbx_Rrim_I_all             5.228 
_reflns_shell.pdbx_Rpim_I_all             1.508 
_reflns_shell.pdbx_CC_half                0.284 
_reflns_shell.percent_possible_all        ? 
_reflns_shell.pdbx_Rsym_value             ? 
_reflns_shell.meanI_over_sigI_obs         ? 
_reflns_shell.number_measured_obs         ? 
_reflns_shell.number_unique_all           ? 
_reflns_shell.pdbx_CC_star                ? 
# 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.entry_id                                 7I2E 
_refine.pdbx_diffrn_id                           1 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     70530 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             74.5 
_refine.ls_d_res_high                            1.72 
_refine.ls_percent_reflns_obs                    97.20 
_refine.ls_R_factor_obs                          0.19486 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       0.19304 
_refine.ls_R_factor_R_free                       0.22776 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 5.1 
_refine.ls_number_reflns_R_free                  3819 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               0.963 
_refine.correlation_coeff_Fo_to_Fc_free          0.955 
_refine.B_iso_mean                               57.246 
_refine.aniso_B[1][1]                            -2.00 
_refine.aniso_B[2][2]                            0.45 
_refine.aniso_B[3][3]                            1.55 
_refine.aniso_B[1][2]                            -0.00 
_refine.aniso_B[1][3]                            0.00 
_refine.aniso_B[2][3]                            -0.00 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_overall_ESU_R                       0.174 
_refine.pdbx_overall_ESU_R_Free                  0.144 
_refine.overall_SU_ML                            0.164 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             5.868 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.pdbx_number_atoms_protein        4687 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         55 
_refine_hist.number_atoms_solvent             406 
_refine_hist.number_atoms_total               5148 
_refine_hist.d_res_high                       1.72 
_refine_hist.d_res_low                        74.5 
# 
loop_
_refine_ls_restr.type 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.weight 
_refine_ls_restr.number 
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.pdbx_restraint_function 
r_bond_refined_d             0.008  0.014  ? 11354 'X-RAY DIFFRACTION' ? 
r_bond_other_d               0.001  0.015  ? 8074  'X-RAY DIFFRACTION' ? 
r_angle_refined_deg          1.488  1.645  ? 11848 'X-RAY DIFFRACTION' ? 
r_angle_other_deg            1.245  1.598  ? 18673 'X-RAY DIFFRACTION' ? 
r_dihedral_angle_1_deg       6.430  5.000  ? 1105  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_2_deg       29.444 20.779 ? 526   'X-RAY DIFFRACTION' ? 
r_dihedral_angle_3_deg       16.629 15.000 ? 1588  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_4_deg       15.439 15.000 ? 89    'X-RAY DIFFRACTION' ? 
r_chiral_restr               0.070  0.200  ? 1056  'X-RAY DIFFRACTION' ? 
r_gen_planes_refined         0.008  0.020  ? 10334 'X-RAY DIFFRACTION' ? 
r_gen_planes_other           0.002  0.020  ? 2240  'X-RAY DIFFRACTION' ? 
r_nbd_refined                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbd_other                  ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_refined              ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_other                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_refined        ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_other          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_refined          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_other            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_refined       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_other         ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_refined     ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_other       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_refined ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_other   ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_mcbond_it                  3.122  5.803  ? 5403  'X-RAY DIFFRACTION' ? 
r_mcbond_other               3.156  5.820  ? 5290  'X-RAY DIFFRACTION' ? 
r_mcangle_it                 5.514  8.195  ? 5307  'X-RAY DIFFRACTION' ? 
r_mcangle_other              5.516  8.198  ? 5306  'X-RAY DIFFRACTION' ? 
r_scbond_it                  3.628  6.553  ? 5951  'X-RAY DIFFRACTION' ? 
r_scbond_other               3.628  6.553  ? 5951  'X-RAY DIFFRACTION' ? 
r_scangle_it                 ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_scangle_other              6.144  9.225  ? 6542  'X-RAY DIFFRACTION' ? 
r_long_range_B_refined       9.036  60.723 ? 10198 'X-RAY DIFFRACTION' ? 
r_long_range_B_other         8.956  60.596 ? 10068 'X-RAY DIFFRACTION' ? 
r_rigid_bond_restr           ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_free            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_bonded          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.d_res_high                       1.720 
_refine_ls_shell.d_res_low                        1.765 
_refine_ls_shell.number_reflns_R_work             3899 
_refine_ls_shell.R_factor_R_work                  0.406 
_refine_ls_shell.percent_reflns_obs               74.18 
_refine_ls_shell.R_factor_R_free                  0.366 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.number_reflns_R_free             213 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.number_reflns_obs                ? 
# 
_struct.entry_id                  7I2E 
_struct.title                     
;Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z740611958 (DNV2_NS5A-x0264)
;
_struct.pdbx_model_details        ? 
_struct.pdbx_CASP_flag            ? 
_struct.pdbx_model_type_details   ? 
# 
_struct_keywords.entry_id        7I2E 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
_struct_keywords.text            
;Diamond Light Source, I04-1, READDI, Dengue Virus, crystallographic fragment screening, PanDDA, XChemExplorer, cluster4x, VIRAL PROTEIN
;
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 5 ? 
H N N 5 ? 
I N N 6 ? 
J N N 7 ? 
K N N 8 ? 
L N N 9 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q91H74_9FLAV 
_struct_ref.pdbx_db_accession          Q91H74 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;GIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAMTD
TTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAREA
VEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLS
GVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRPTP
RGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGDDC
VVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQGAG
WSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPWME
DKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_struct_ref.pdbx_align_begin           2757 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              7I2E 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 3 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 637 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q91H74 
_struct_ref_seq.db_align_beg                  2757 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3391 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       266 
_struct_ref_seq.pdbx_auth_seq_align_end       900 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 7I2E GLY A 1 ? UNP Q91H74 ? ? 'expression tag' 264 1 
1 7I2E PRO A 2 ? UNP Q91H74 ? ? 'expression tag' 265 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 10  ? HIS A 25  ? ASN A 273 HIS A 288 1 ? 16 
HELX_P HELX_P2  AA2 ASN A 59  ? LEU A 65  ? ASN A 322 LEU A 328 1 ? 7  
HELX_P HELX_P3  AA3 THR A 66  ? ILE A 71  ? THR A 329 ILE A 334 5 ? 6  
HELX_P HELX_P4  AA4 ILE A 72  ? GLN A 77  ? ILE A 335 GLN A 340 1 ? 6  
HELX_P HELX_P5  AA5 MET A 78  ? MET A 80  ? MET A 341 MET A 343 5 ? 3  
HELX_P HELX_P6  AA6 LYS A 104 ? LYS A 124 ? LYS A 367 LYS A 387 1 ? 21 
HELX_P HELX_P7  AA7 THR A 132 ? ARG A 141 ? THR A 395 ARG A 404 1 ? 10 
HELX_P HELX_P8  AA8 SER A 158 ? ASP A 165 ? SER A 421 ASP A 428 1 ? 8  
HELX_P HELX_P9  AA9 ASP A 165 ? GLU A 181 ? ASP A 428 GLU A 444 1 ? 17 
HELX_P HELX_P10 AB1 TRP A 215 ? GLY A 227 ? TRP A 478 GLY A 490 1 ? 13 
HELX_P HELX_P11 AB2 GLY A 227 ? ASP A 232 ? GLY A 490 ASP A 495 1 ? 6  
HELX_P HELX_P12 AB3 SER A 236 ? LEU A 241 ? SER A 499 LEU A 504 1 ? 6  
HELX_P HELX_P13 AB4 GLY A 248 ? LYS A 261 ? GLY A 511 LYS A 524 1 ? 14 
HELX_P HELX_P14 AB5 GLY A 274 ? ILE A 279 ? GLY A 537 ILE A 542 5 ? 6  
HELX_P HELX_P15 AB6 THR A 280 ? MET A 289 ? THR A 543 MET A 552 1 ? 10 
HELX_P HELX_P16 AB7 VAL A 290 ? MET A 294 ? VAL A 553 MET A 557 5 ? 5  
HELX_P HELX_P17 AB8 GLU A 295 ? TYR A 310 ? GLU A 558 TYR A 573 1 ? 16 
HELX_P HELX_P18 AB9 GLY A 339 ? GLU A 363 ? GLY A 602 GLU A 626 1 ? 25 
HELX_P HELX_P19 AC1 THR A 373 ? SER A 393 ? THR A 636 SER A 656 1 ? 21 
HELX_P HELX_P20 AC2 ASP A 408 ? ALA A 414 ? ASP A 671 ALA A 677 5 ? 7  
HELX_P HELX_P21 AC3 LEU A 415 ? MET A 421 ? LEU A 678 MET A 684 1 ? 7  
HELX_P HELX_P22 AC4 ASP A 439 ? VAL A 443 ? ASP A 702 VAL A 706 5 ? 5  
HELX_P HELX_P23 AC5 ASN A 467 ? ARG A 476 ? ASN A 730 ARG A 739 1 ? 10 
HELX_P HELX_P24 AC6 SER A 484 ? TYR A 503 ? SER A 747 TYR A 766 1 ? 20 
HELX_P HELX_P25 AC7 ARG A 506 ? VAL A 520 ? ARG A 769 VAL A 783 1 ? 15 
HELX_P HELX_P26 AC8 ASP A 545 ? ILE A 555 ? ASP A 808 ILE A 818 1 ? 11 
HELX_P HELX_P27 AC9 SER A 569 ? ILE A 573 ? SER A 832 ILE A 836 5 ? 5  
HELX_P HELX_P28 AD1 GLY A 577 ? CYS A 584 ? GLY A 840 CYS A 847 1 ? 8  
HELX_P HELX_P29 AD2 LEU A 590 ? ASN A 599 ? LEU A 853 ASN A 862 1 ? 10 
HELX_P HELX_P30 AD3 ASN A 599 ? GLY A 612 ? ASN A 862 GLY A 875 1 ? 14 
HELX_P HELX_P31 AD4 TYR A 619 ? ARG A 627 ? TYR A 882 ARG A 890 5 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A GLU 175 OE1 ? ? ? 1_555 C ZN . ZN ? ? A GLU 438 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.208 ? ? 
metalc2 metalc ? ? A HIS 179 NE2 ? ? ? 1_555 C ZN . ZN ? ? A HIS 442 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.084 ? ? 
metalc3 metalc ? ? A CYS 184 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 447 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.192 ? ? 
metalc4 metalc ? ? A CYS 187 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 450 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.094 ? ? 
metalc5 metalc ? ? A HIS 449 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 712 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.084 ? ? 
metalc6 metalc ? ? A HIS 451 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 714 A ZN 1001 1_555 ? ? ? ? ? ? ? 1.993 ? ? 
metalc7 metalc ? ? A CYS 465 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 728 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.375 ? ? 
metalc8 metalc ? ? A CYS 584 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 847 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.310 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 NE2 ? A HIS 179 ? A HIS 442 ? 1_555 109.6 ? 
2  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 119.5 ? 
3  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 117.9 ? 
4  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 76.7  ? 
5  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 113.4 ? 
6  SG  ? A CYS 184 ? A CYS 447 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 112.9 ? 
7  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 101.3 ? 
8  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 106.2 ? 
9  NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 107.0 ? 
10 NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 104.3 ? 
11 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 119.0 ? 
12 SG  ? A CYS 465 ? A CYS 728 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 117.0 ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 41  ? GLU A 47  ? ALA A 304 GLU A 310 
AA1 2 VAL A 326 ? SER A 331 ? VAL A 589 SER A 594 
AA1 3 VAL A 315 ? ARG A 319 ? VAL A 578 ARG A 582 
AA1 4 TYR A 189 ? MET A 191 ? TYR A 452 MET A 454 
AA1 5 TRP A 212 ? TYR A 213 ? TRP A 475 TYR A 476 
AA2 1 SER A 56  ? VAL A 58  ? SER A 319 VAL A 321 
AA2 2 ILE A 477 ? GLN A 479 ? ILE A 740 GLN A 742 
AA3 1 MET A 395 ? SER A 398 ? MET A 658 SER A 661 
AA3 2 ASP A 401 ? VAL A 404 ? ASP A 664 VAL A 667 
AA4 1 HIS A 449 ? ILE A 454 ? HIS A 712 ILE A 717 
AA4 2 VAL A 460 ? CYS A 465 ? VAL A 723 CYS A 728 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N ALA A 41  ? N ALA A 304 O SER A 331 ? O SER A 594 
AA1 2 3 O ILE A 330 ? O ILE A 593 N VAL A 315 ? N VAL A 578 
AA1 3 4 O ARG A 316 ? O ARG A 579 N MET A 191 ? N MET A 454 
AA1 4 5 N ASN A 190 ? N ASN A 453 O TYR A 213 ? O TYR A 476 
AA2 1 2 N MET A 57  ? N MET A 320 O SER A 478 ? O SER A 741 
AA3 1 2 N SER A 398 ? N SER A 661 O ASP A 401 ? O ASP A 664 
AA4 1 2 N LEU A 453 ? N LEU A 716 O LEU A 461 ? O LEU A 724 
# 
_pdbx_entry_details.entry_id                   7I2E 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
_pdbx_validate_close_contact.id               1 
_pdbx_validate_close_contact.PDB_model_num    1 
_pdbx_validate_close_contact.auth_atom_id_1   OD1 
_pdbx_validate_close_contact.auth_asym_id_1   A 
_pdbx_validate_close_contact.auth_comp_id_1   ASP 
_pdbx_validate_close_contact.auth_seq_id_1    664 
_pdbx_validate_close_contact.PDB_ins_code_1   ? 
_pdbx_validate_close_contact.label_alt_id_1   ? 
_pdbx_validate_close_contact.auth_atom_id_2   O4 
_pdbx_validate_close_contact.auth_asym_id_2   A 
_pdbx_validate_close_contact.auth_comp_id_2   PO4 
_pdbx_validate_close_contact.auth_seq_id_2    1006 
_pdbx_validate_close_contact.PDB_ins_code_2   ? 
_pdbx_validate_close_contact.label_alt_id_2   ? 
_pdbx_validate_close_contact.dist             2.00 
# 
_pdbx_validate_symm_contact.id                1 
_pdbx_validate_symm_contact.PDB_model_num     1 
_pdbx_validate_symm_contact.auth_atom_id_1    O 
_pdbx_validate_symm_contact.auth_asym_id_1    A 
_pdbx_validate_symm_contact.auth_comp_id_1    HOH 
_pdbx_validate_symm_contact.auth_seq_id_1     1145 
_pdbx_validate_symm_contact.PDB_ins_code_1    ? 
_pdbx_validate_symm_contact.label_alt_id_1    ? 
_pdbx_validate_symm_contact.site_symmetry_1   1_555 
_pdbx_validate_symm_contact.auth_atom_id_2    O 
_pdbx_validate_symm_contact.auth_asym_id_2    A 
_pdbx_validate_symm_contact.auth_comp_id_2    HOH 
_pdbx_validate_symm_contact.auth_seq_id_2     1145 
_pdbx_validate_symm_contact.PDB_ins_code_2    ? 
_pdbx_validate_symm_contact.label_alt_id_2    ? 
_pdbx_validate_symm_contact.site_symmetry_2   2_445 
_pdbx_validate_symm_contact.dist              1.72 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             NE 
_pdbx_validate_rmsd_angle.auth_asym_id_1             A 
_pdbx_validate_rmsd_angle.auth_comp_id_1             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_1              739 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CZ 
_pdbx_validate_rmsd_angle.auth_asym_id_2             A 
_pdbx_validate_rmsd_angle.auth_comp_id_2             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_2              739 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             NH1 
_pdbx_validate_rmsd_angle.auth_asym_id_3             A 
_pdbx_validate_rmsd_angle.auth_comp_id_3             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_3              739 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                123.96 
_pdbx_validate_rmsd_angle.angle_target_value         120.30 
_pdbx_validate_rmsd_angle.angle_deviation            3.66 
_pdbx_validate_rmsd_angle.angle_standard_deviation   0.50 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 TRP A 292 ? ? -69.87  79.39  
2 1 ASP A 295 ? ? -66.87  99.50  
3 1 ASP A 297 ? ? -95.09  39.09  
4 1 LEU A 504 ? ? 67.97   -37.42 
5 1 ASN A 575 ? ? -152.30 87.78  
6 1 GLN A 598 ? ? 77.96   159.99 
7 1 HIS A 634 ? ? -170.72 131.62 
8 1 HIS A 801 ? ? -103.52 78.12  
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A HOH 1153 ? L HOH . 
2 1 A HOH 1232 ? L HOH . 
3 1 A HOH 1424 ? L HOH . 
4 1 A HOH 1430 ? L HOH . 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 1505 ? 5.92 . 
2 1 O ? A HOH 1506 ? 6.44 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 264 ? A GLY 1   
2  1 Y 1 A PRO 265 ? A PRO 2   
3  1 Y 1 A GLY 266 ? A GLY 3   
4  1 Y 1 A ILE 267 ? A ILE 4   
5  1 Y 1 A GLU 268 ? A GLU 5   
6  1 Y 1 A SER 269 ? A SER 6   
7  1 Y 1 A GLU 270 ? A GLU 7   
8  1 Y 1 A THR 271 ? A THR 8   
9  1 Y 1 A PRO 272 ? A PRO 9   
10 1 Y 1 A GLN 313 ? A GLN 50  
11 1 Y 1 A THR 314 ? A THR 51  
12 1 Y 1 A GLY 315 ? A GLY 52  
13 1 Y 1 A SER 316 ? A SER 53  
14 1 Y 1 A ALA 317 ? A ALA 54  
15 1 Y 1 A ASP 345 ? A ASP 82  
16 1 Y 1 A THR 346 ? A THR 83  
17 1 Y 1 A THR 347 ? A THR 84  
18 1 Y 1 A PRO 348 ? A PRO 85  
19 1 Y 1 A PHE 349 ? A PHE 86  
20 1 Y 1 A GLY 350 ? A GLY 87  
21 1 Y 1 A GLN 351 ? A GLN 88  
22 1 Y 1 A GLN 352 ? A GLN 89  
23 1 Y 1 A ARG 353 ? A ARG 90  
24 1 Y 1 A VAL 354 ? A VAL 91  
25 1 Y 1 A PHE 355 ? A PHE 92  
26 1 Y 1 A PHE 413 ? A PHE 150 
27 1 Y 1 A THR 414 ? A THR 151 
28 1 Y 1 A ASP 415 ? A ASP 152 
29 1 Y 1 A GLU 416 ? A GLU 153 
30 1 Y 1 A ASN 417 ? A ASN 154 
31 1 Y 1 A GLY 456 ? A GLY 193 
32 1 Y 1 A LYS 457 ? A LYS 194 
33 1 Y 1 A ARG 458 ? A ARG 195 
34 1 Y 1 A GLU 459 ? A GLU 196 
35 1 Y 1 A LYS 460 ? A LYS 197 
36 1 Y 1 A LYS 461 ? A LYS 198 
37 1 Y 1 A LEU 462 ? A LEU 199 
38 1 Y 1 A GLY 463 ? A GLY 200 
39 1 Y 1 A GLU 464 ? A GLU 201 
40 1 Y 1 A PHE 465 ? A PHE 202 
41 1 Y 1 A GLY 466 ? A GLY 203 
42 1 Y 1 A LYS 467 ? A LYS 204 
43 1 Y 1 A ALA 468 ? A ALA 205 
44 1 Y 1 A LYS 469 ? A LYS 206 
45 1 Y 1 A GLY 470 ? A GLY 207 
46 1 Y 1 A SER 471 ? A SER 208 
47 1 Y 1 A ARG 472 ? A ARG 209 
48 1 Y 1 A PRO 585 ? A PRO 322 
49 1 Y 1 A ARG 586 ? A ARG 323 
50 1 Y 1 A GLY 587 ? A GLY 324 
51 1 Y 1 A THR 793 ? A THR 530 
52 1 Y 1 A THR 794 ? A THR 531 
53 1 Y 1 A TRP 795 ? A TRP 532 
54 1 Y 1 A SER 796 ? A SER 533 
55 1 Y 1 A ILE 797 ? A ILE 534 
56 1 Y 1 A GLU 892 ? A GLU 629 
57 1 Y 1 A GLU 893 ? A GLU 630 
58 1 Y 1 A GLU 894 ? A GLU 631 
59 1 Y 1 A GLU 895 ? A GLU 632 
60 1 Y 1 A ALA 896 ? A ALA 633 
61 1 Y 1 A GLY 897 ? A GLY 634 
62 1 Y 1 A VAL 898 ? A VAL 635 
63 1 Y 1 A LEU 899 ? A LEU 636 
64 1 Y 1 A TRP 900 ? A TRP 637 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
A1BZQ N1   N  Y N 1   
A1BZQ C4   C  N S 2   
A1BZQ C5   C  N N 3   
A1BZQ C6   C  Y N 4   
A1BZQ C7   C  Y N 5   
A1BZQ C8   C  N N 6   
A1BZQ C10  C  N N 7   
A1BZQ N    N  N N 8   
A1BZQ C    C  N N 9   
A1BZQ O    O  N N 10  
A1BZQ C1   C  N N 11  
A1BZQ C2   C  N N 12  
A1BZQ C3   C  N N 13  
A1BZQ C9   C  Y N 14  
A1BZQ S    S  Y N 15  
A1BZQ H8   H  N N 16  
A1BZQ H11  H  N N 17  
A1BZQ H10  H  N N 18  
A1BZQ H9   H  N N 19  
A1BZQ H13  H  N N 20  
A1BZQ H12  H  N N 21  
A1BZQ H14  H  N N 22  
A1BZQ H16  H  N N 23  
A1BZQ H15  H  N N 24  
A1BZQ H17  H  N N 25  
A1BZQ H7   H  N N 26  
A1BZQ H1   H  N N 27  
A1BZQ H    H  N N 28  
A1BZQ H2   H  N N 29  
A1BZQ H3   H  N N 30  
A1BZQ H6   H  N N 31  
A1BZQ H4   H  N N 32  
A1BZQ H5   H  N N 33  
ALA   N    N  N N 34  
ALA   CA   C  N S 35  
ALA   C    C  N N 36  
ALA   O    O  N N 37  
ALA   CB   C  N N 38  
ALA   OXT  O  N N 39  
ALA   H    H  N N 40  
ALA   H2   H  N N 41  
ALA   HA   H  N N 42  
ALA   HB1  H  N N 43  
ALA   HB2  H  N N 44  
ALA   HB3  H  N N 45  
ALA   HXT  H  N N 46  
ARG   N    N  N N 47  
ARG   CA   C  N S 48  
ARG   C    C  N N 49  
ARG   O    O  N N 50  
ARG   CB   C  N N 51  
ARG   CG   C  N N 52  
ARG   CD   C  N N 53  
ARG   NE   N  N N 54  
ARG   CZ   C  N N 55  
ARG   NH1  N  N N 56  
ARG   NH2  N  N N 57  
ARG   OXT  O  N N 58  
ARG   H    H  N N 59  
ARG   H2   H  N N 60  
ARG   HA   H  N N 61  
ARG   HB2  H  N N 62  
ARG   HB3  H  N N 63  
ARG   HG2  H  N N 64  
ARG   HG3  H  N N 65  
ARG   HD2  H  N N 66  
ARG   HD3  H  N N 67  
ARG   HE   H  N N 68  
ARG   HH11 H  N N 69  
ARG   HH12 H  N N 70  
ARG   HH21 H  N N 71  
ARG   HH22 H  N N 72  
ARG   HXT  H  N N 73  
ASN   N    N  N N 74  
ASN   CA   C  N S 75  
ASN   C    C  N N 76  
ASN   O    O  N N 77  
ASN   CB   C  N N 78  
ASN   CG   C  N N 79  
ASN   OD1  O  N N 80  
ASN   ND2  N  N N 81  
ASN   OXT  O  N N 82  
ASN   H    H  N N 83  
ASN   H2   H  N N 84  
ASN   HA   H  N N 85  
ASN   HB2  H  N N 86  
ASN   HB3  H  N N 87  
ASN   HD21 H  N N 88  
ASN   HD22 H  N N 89  
ASN   HXT  H  N N 90  
ASP   N    N  N N 91  
ASP   CA   C  N S 92  
ASP   C    C  N N 93  
ASP   O    O  N N 94  
ASP   CB   C  N N 95  
ASP   CG   C  N N 96  
ASP   OD1  O  N N 97  
ASP   OD2  O  N N 98  
ASP   OXT  O  N N 99  
ASP   H    H  N N 100 
ASP   H2   H  N N 101 
ASP   HA   H  N N 102 
ASP   HB2  H  N N 103 
ASP   HB3  H  N N 104 
ASP   HD2  H  N N 105 
ASP   HXT  H  N N 106 
CL    CL   CL N N 107 
CYS   N    N  N N 108 
CYS   CA   C  N R 109 
CYS   C    C  N N 110 
CYS   O    O  N N 111 
CYS   CB   C  N N 112 
CYS   SG   S  N N 113 
CYS   OXT  O  N N 114 
CYS   H    H  N N 115 
CYS   H2   H  N N 116 
CYS   HA   H  N N 117 
CYS   HB2  H  N N 118 
CYS   HB3  H  N N 119 
CYS   HG   H  N N 120 
CYS   HXT  H  N N 121 
DMS   S    S  N N 122 
DMS   O    O  N N 123 
DMS   C1   C  N N 124 
DMS   C2   C  N N 125 
DMS   H11  H  N N 126 
DMS   H12  H  N N 127 
DMS   H13  H  N N 128 
DMS   H21  H  N N 129 
DMS   H22  H  N N 130 
DMS   H23  H  N N 131 
GLN   N    N  N N 132 
GLN   CA   C  N S 133 
GLN   C    C  N N 134 
GLN   O    O  N N 135 
GLN   CB   C  N N 136 
GLN   CG   C  N N 137 
GLN   CD   C  N N 138 
GLN   OE1  O  N N 139 
GLN   NE2  N  N N 140 
GLN   OXT  O  N N 141 
GLN   H    H  N N 142 
GLN   H2   H  N N 143 
GLN   HA   H  N N 144 
GLN   HB2  H  N N 145 
GLN   HB3  H  N N 146 
GLN   HG2  H  N N 147 
GLN   HG3  H  N N 148 
GLN   HE21 H  N N 149 
GLN   HE22 H  N N 150 
GLN   HXT  H  N N 151 
GLU   N    N  N N 152 
GLU   CA   C  N S 153 
GLU   C    C  N N 154 
GLU   O    O  N N 155 
GLU   CB   C  N N 156 
GLU   CG   C  N N 157 
GLU   CD   C  N N 158 
GLU   OE1  O  N N 159 
GLU   OE2  O  N N 160 
GLU   OXT  O  N N 161 
GLU   H    H  N N 162 
GLU   H2   H  N N 163 
GLU   HA   H  N N 164 
GLU   HB2  H  N N 165 
GLU   HB3  H  N N 166 
GLU   HG2  H  N N 167 
GLU   HG3  H  N N 168 
GLU   HE2  H  N N 169 
GLU   HXT  H  N N 170 
GLY   N    N  N N 171 
GLY   CA   C  N N 172 
GLY   C    C  N N 173 
GLY   O    O  N N 174 
GLY   OXT  O  N N 175 
GLY   H    H  N N 176 
GLY   H2   H  N N 177 
GLY   HA2  H  N N 178 
GLY   HA3  H  N N 179 
GLY   HXT  H  N N 180 
HIS   N    N  N N 181 
HIS   CA   C  N S 182 
HIS   C    C  N N 183 
HIS   O    O  N N 184 
HIS   CB   C  N N 185 
HIS   CG   C  Y N 186 
HIS   ND1  N  Y N 187 
HIS   CD2  C  Y N 188 
HIS   CE1  C  Y N 189 
HIS   NE2  N  Y N 190 
HIS   OXT  O  N N 191 
HIS   H    H  N N 192 
HIS   H2   H  N N 193 
HIS   HA   H  N N 194 
HIS   HB2  H  N N 195 
HIS   HB3  H  N N 196 
HIS   HD1  H  N N 197 
HIS   HD2  H  N N 198 
HIS   HE1  H  N N 199 
HIS   HE2  H  N N 200 
HIS   HXT  H  N N 201 
HOH   O    O  N N 202 
HOH   H1   H  N N 203 
HOH   H2   H  N N 204 
ILE   N    N  N N 205 
ILE   CA   C  N S 206 
ILE   C    C  N N 207 
ILE   O    O  N N 208 
ILE   CB   C  N S 209 
ILE   CG1  C  N N 210 
ILE   CG2  C  N N 211 
ILE   CD1  C  N N 212 
ILE   OXT  O  N N 213 
ILE   H    H  N N 214 
ILE   H2   H  N N 215 
ILE   HA   H  N N 216 
ILE   HB   H  N N 217 
ILE   HG12 H  N N 218 
ILE   HG13 H  N N 219 
ILE   HG21 H  N N 220 
ILE   HG22 H  N N 221 
ILE   HG23 H  N N 222 
ILE   HD11 H  N N 223 
ILE   HD12 H  N N 224 
ILE   HD13 H  N N 225 
ILE   HXT  H  N N 226 
LEU   N    N  N N 227 
LEU   CA   C  N S 228 
LEU   C    C  N N 229 
LEU   O    O  N N 230 
LEU   CB   C  N N 231 
LEU   CG   C  N N 232 
LEU   CD1  C  N N 233 
LEU   CD2  C  N N 234 
LEU   OXT  O  N N 235 
LEU   H    H  N N 236 
LEU   H2   H  N N 237 
LEU   HA   H  N N 238 
LEU   HB2  H  N N 239 
LEU   HB3  H  N N 240 
LEU   HG   H  N N 241 
LEU   HD11 H  N N 242 
LEU   HD12 H  N N 243 
LEU   HD13 H  N N 244 
LEU   HD21 H  N N 245 
LEU   HD22 H  N N 246 
LEU   HD23 H  N N 247 
LEU   HXT  H  N N 248 
LYS   N    N  N N 249 
LYS   CA   C  N S 250 
LYS   C    C  N N 251 
LYS   O    O  N N 252 
LYS   CB   C  N N 253 
LYS   CG   C  N N 254 
LYS   CD   C  N N 255 
LYS   CE   C  N N 256 
LYS   NZ   N  N N 257 
LYS   OXT  O  N N 258 
LYS   H    H  N N 259 
LYS   H2   H  N N 260 
LYS   HA   H  N N 261 
LYS   HB2  H  N N 262 
LYS   HB3  H  N N 263 
LYS   HG2  H  N N 264 
LYS   HG3  H  N N 265 
LYS   HD2  H  N N 266 
LYS   HD3  H  N N 267 
LYS   HE2  H  N N 268 
LYS   HE3  H  N N 269 
LYS   HZ1  H  N N 270 
LYS   HZ2  H  N N 271 
LYS   HZ3  H  N N 272 
LYS   HXT  H  N N 273 
MES   O1   O  N N 274 
MES   C2   C  N N 275 
MES   C3   C  N N 276 
MES   N4   N  N N 277 
MES   C5   C  N N 278 
MES   C6   C  N N 279 
MES   C7   C  N N 280 
MES   C8   C  N N 281 
MES   S    S  N N 282 
MES   O1S  O  N N 283 
MES   O2S  O  N N 284 
MES   O3S  O  N N 285 
MES   H21  H  N N 286 
MES   H22  H  N N 287 
MES   H31  H  N N 288 
MES   H32  H  N N 289 
MES   HN4  H  N N 290 
MES   H51  H  N N 291 
MES   H52  H  N N 292 
MES   H61  H  N N 293 
MES   H62  H  N N 294 
MES   H71  H  N N 295 
MES   H72  H  N N 296 
MES   H81  H  N N 297 
MES   H82  H  N N 298 
MET   N    N  N N 299 
MET   CA   C  N S 300 
MET   C    C  N N 301 
MET   O    O  N N 302 
MET   CB   C  N N 303 
MET   CG   C  N N 304 
MET   SD   S  N N 305 
MET   CE   C  N N 306 
MET   OXT  O  N N 307 
MET   H    H  N N 308 
MET   H2   H  N N 309 
MET   HA   H  N N 310 
MET   HB2  H  N N 311 
MET   HB3  H  N N 312 
MET   HG2  H  N N 313 
MET   HG3  H  N N 314 
MET   HE1  H  N N 315 
MET   HE2  H  N N 316 
MET   HE3  H  N N 317 
MET   HXT  H  N N 318 
PEG   C1   C  N N 319 
PEG   O1   O  N N 320 
PEG   C2   C  N N 321 
PEG   O2   O  N N 322 
PEG   C3   C  N N 323 
PEG   C4   C  N N 324 
PEG   O4   O  N N 325 
PEG   H11  H  N N 326 
PEG   H12  H  N N 327 
PEG   HO1  H  N N 328 
PEG   H21  H  N N 329 
PEG   H22  H  N N 330 
PEG   H31  H  N N 331 
PEG   H32  H  N N 332 
PEG   H41  H  N N 333 
PEG   H42  H  N N 334 
PEG   HO4  H  N N 335 
PHE   N    N  N N 336 
PHE   CA   C  N S 337 
PHE   C    C  N N 338 
PHE   O    O  N N 339 
PHE   CB   C  N N 340 
PHE   CG   C  Y N 341 
PHE   CD1  C  Y N 342 
PHE   CD2  C  Y N 343 
PHE   CE1  C  Y N 344 
PHE   CE2  C  Y N 345 
PHE   CZ   C  Y N 346 
PHE   OXT  O  N N 347 
PHE   H    H  N N 348 
PHE   H2   H  N N 349 
PHE   HA   H  N N 350 
PHE   HB2  H  N N 351 
PHE   HB3  H  N N 352 
PHE   HD1  H  N N 353 
PHE   HD2  H  N N 354 
PHE   HE1  H  N N 355 
PHE   HE2  H  N N 356 
PHE   HZ   H  N N 357 
PHE   HXT  H  N N 358 
PO4   P    P  N N 359 
PO4   O1   O  N N 360 
PO4   O2   O  N N 361 
PO4   O3   O  N N 362 
PO4   O4   O  N N 363 
PRO   N    N  N N 364 
PRO   CA   C  N S 365 
PRO   C    C  N N 366 
PRO   O    O  N N 367 
PRO   CB   C  N N 368 
PRO   CG   C  N N 369 
PRO   CD   C  N N 370 
PRO   OXT  O  N N 371 
PRO   H    H  N N 372 
PRO   HA   H  N N 373 
PRO   HB2  H  N N 374 
PRO   HB3  H  N N 375 
PRO   HG2  H  N N 376 
PRO   HG3  H  N N 377 
PRO   HD2  H  N N 378 
PRO   HD3  H  N N 379 
PRO   HXT  H  N N 380 
SER   N    N  N N 381 
SER   CA   C  N S 382 
SER   C    C  N N 383 
SER   O    O  N N 384 
SER   CB   C  N N 385 
SER   OG   O  N N 386 
SER   OXT  O  N N 387 
SER   H    H  N N 388 
SER   H2   H  N N 389 
SER   HA   H  N N 390 
SER   HB2  H  N N 391 
SER   HB3  H  N N 392 
SER   HG   H  N N 393 
SER   HXT  H  N N 394 
THR   N    N  N N 395 
THR   CA   C  N S 396 
THR   C    C  N N 397 
THR   O    O  N N 398 
THR   CB   C  N R 399 
THR   OG1  O  N N 400 
THR   CG2  C  N N 401 
THR   OXT  O  N N 402 
THR   H    H  N N 403 
THR   H2   H  N N 404 
THR   HA   H  N N 405 
THR   HB   H  N N 406 
THR   HG1  H  N N 407 
THR   HG21 H  N N 408 
THR   HG22 H  N N 409 
THR   HG23 H  N N 410 
THR   HXT  H  N N 411 
TRP   N    N  N N 412 
TRP   CA   C  N S 413 
TRP   C    C  N N 414 
TRP   O    O  N N 415 
TRP   CB   C  N N 416 
TRP   CG   C  Y N 417 
TRP   CD1  C  Y N 418 
TRP   CD2  C  Y N 419 
TRP   NE1  N  Y N 420 
TRP   CE2  C  Y N 421 
TRP   CE3  C  Y N 422 
TRP   CZ2  C  Y N 423 
TRP   CZ3  C  Y N 424 
TRP   CH2  C  Y N 425 
TRP   OXT  O  N N 426 
TRP   H    H  N N 427 
TRP   H2   H  N N 428 
TRP   HA   H  N N 429 
TRP   HB2  H  N N 430 
TRP   HB3  H  N N 431 
TRP   HD1  H  N N 432 
TRP   HE1  H  N N 433 
TRP   HE3  H  N N 434 
TRP   HZ2  H  N N 435 
TRP   HZ3  H  N N 436 
TRP   HH2  H  N N 437 
TRP   HXT  H  N N 438 
TYR   N    N  N N 439 
TYR   CA   C  N S 440 
TYR   C    C  N N 441 
TYR   O    O  N N 442 
TYR   CB   C  N N 443 
TYR   CG   C  Y N 444 
TYR   CD1  C  Y N 445 
TYR   CD2  C  Y N 446 
TYR   CE1  C  Y N 447 
TYR   CE2  C  Y N 448 
TYR   CZ   C  Y N 449 
TYR   OH   O  N N 450 
TYR   OXT  O  N N 451 
TYR   H    H  N N 452 
TYR   H2   H  N N 453 
TYR   HA   H  N N 454 
TYR   HB2  H  N N 455 
TYR   HB3  H  N N 456 
TYR   HD1  H  N N 457 
TYR   HD2  H  N N 458 
TYR   HE1  H  N N 459 
TYR   HE2  H  N N 460 
TYR   HH   H  N N 461 
TYR   HXT  H  N N 462 
VAL   N    N  N N 463 
VAL   CA   C  N S 464 
VAL   C    C  N N 465 
VAL   O    O  N N 466 
VAL   CB   C  N N 467 
VAL   CG1  C  N N 468 
VAL   CG2  C  N N 469 
VAL   OXT  O  N N 470 
VAL   H    H  N N 471 
VAL   H2   H  N N 472 
VAL   HA   H  N N 473 
VAL   HB   H  N N 474 
VAL   HG11 H  N N 475 
VAL   HG12 H  N N 476 
VAL   HG13 H  N N 477 
VAL   HG21 H  N N 478 
VAL   HG22 H  N N 479 
VAL   HG23 H  N N 480 
VAL   HXT  H  N N 481 
ZN    ZN   ZN N N 482 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
A1BZQ C   C1   sing N N 1   
A1BZQ C2  C1   sing N N 2   
A1BZQ C1  C3   sing N N 3   
A1BZQ C3  O    doub N N 4   
A1BZQ N   C3   sing N N 5   
A1BZQ C4  N    sing N N 6   
A1BZQ C5  C4   sing N N 7   
A1BZQ C6  C4   sing N N 8   
A1BZQ C6  S    sing Y N 9   
A1BZQ S   C7   sing Y N 10  
A1BZQ C8  C7   sing N N 11  
A1BZQ C7  N1   doub Y N 12  
A1BZQ N1  C9   sing Y N 13  
A1BZQ C9  C6   doub Y N 14  
A1BZQ C10 C9   sing N N 15  
A1BZQ C4  H8   sing N N 16  
A1BZQ C5  H11  sing N N 17  
A1BZQ C5  H10  sing N N 18  
A1BZQ C5  H9   sing N N 19  
A1BZQ C8  H13  sing N N 20  
A1BZQ C8  H12  sing N N 21  
A1BZQ C8  H14  sing N N 22  
A1BZQ C10 H16  sing N N 23  
A1BZQ C10 H15  sing N N 24  
A1BZQ C10 H17  sing N N 25  
A1BZQ N   H7   sing N N 26  
A1BZQ C   H1   sing N N 27  
A1BZQ C   H    sing N N 28  
A1BZQ C   H2   sing N N 29  
A1BZQ C1  H3   sing N N 30  
A1BZQ C2  H6   sing N N 31  
A1BZQ C2  H4   sing N N 32  
A1BZQ C2  H5   sing N N 33  
ALA   N   CA   sing N N 34  
ALA   N   H    sing N N 35  
ALA   N   H2   sing N N 36  
ALA   CA  C    sing N N 37  
ALA   CA  CB   sing N N 38  
ALA   CA  HA   sing N N 39  
ALA   C   O    doub N N 40  
ALA   C   OXT  sing N N 41  
ALA   CB  HB1  sing N N 42  
ALA   CB  HB2  sing N N 43  
ALA   CB  HB3  sing N N 44  
ALA   OXT HXT  sing N N 45  
ARG   N   CA   sing N N 46  
ARG   N   H    sing N N 47  
ARG   N   H2   sing N N 48  
ARG   CA  C    sing N N 49  
ARG   CA  CB   sing N N 50  
ARG   CA  HA   sing N N 51  
ARG   C   O    doub N N 52  
ARG   C   OXT  sing N N 53  
ARG   CB  CG   sing N N 54  
ARG   CB  HB2  sing N N 55  
ARG   CB  HB3  sing N N 56  
ARG   CG  CD   sing N N 57  
ARG   CG  HG2  sing N N 58  
ARG   CG  HG3  sing N N 59  
ARG   CD  NE   sing N N 60  
ARG   CD  HD2  sing N N 61  
ARG   CD  HD3  sing N N 62  
ARG   NE  CZ   sing N N 63  
ARG   NE  HE   sing N N 64  
ARG   CZ  NH1  sing N N 65  
ARG   CZ  NH2  doub N N 66  
ARG   NH1 HH11 sing N N 67  
ARG   NH1 HH12 sing N N 68  
ARG   NH2 HH21 sing N N 69  
ARG   NH2 HH22 sing N N 70  
ARG   OXT HXT  sing N N 71  
ASN   N   CA   sing N N 72  
ASN   N   H    sing N N 73  
ASN   N   H2   sing N N 74  
ASN   CA  C    sing N N 75  
ASN   CA  CB   sing N N 76  
ASN   CA  HA   sing N N 77  
ASN   C   O    doub N N 78  
ASN   C   OXT  sing N N 79  
ASN   CB  CG   sing N N 80  
ASN   CB  HB2  sing N N 81  
ASN   CB  HB3  sing N N 82  
ASN   CG  OD1  doub N N 83  
ASN   CG  ND2  sing N N 84  
ASN   ND2 HD21 sing N N 85  
ASN   ND2 HD22 sing N N 86  
ASN   OXT HXT  sing N N 87  
ASP   N   CA   sing N N 88  
ASP   N   H    sing N N 89  
ASP   N   H2   sing N N 90  
ASP   CA  C    sing N N 91  
ASP   CA  CB   sing N N 92  
ASP   CA  HA   sing N N 93  
ASP   C   O    doub N N 94  
ASP   C   OXT  sing N N 95  
ASP   CB  CG   sing N N 96  
ASP   CB  HB2  sing N N 97  
ASP   CB  HB3  sing N N 98  
ASP   CG  OD1  doub N N 99  
ASP   CG  OD2  sing N N 100 
ASP   OD2 HD2  sing N N 101 
ASP   OXT HXT  sing N N 102 
CYS   N   CA   sing N N 103 
CYS   N   H    sing N N 104 
CYS   N   H2   sing N N 105 
CYS   CA  C    sing N N 106 
CYS   CA  CB   sing N N 107 
CYS   CA  HA   sing N N 108 
CYS   C   O    doub N N 109 
CYS   C   OXT  sing N N 110 
CYS   CB  SG   sing N N 111 
CYS   CB  HB2  sing N N 112 
CYS   CB  HB3  sing N N 113 
CYS   SG  HG   sing N N 114 
CYS   OXT HXT  sing N N 115 
DMS   S   O    doub N N 116 
DMS   S   C1   sing N N 117 
DMS   S   C2   sing N N 118 
DMS   C1  H11  sing N N 119 
DMS   C1  H12  sing N N 120 
DMS   C1  H13  sing N N 121 
DMS   C2  H21  sing N N 122 
DMS   C2  H22  sing N N 123 
DMS   C2  H23  sing N N 124 
GLN   N   CA   sing N N 125 
GLN   N   H    sing N N 126 
GLN   N   H2   sing N N 127 
GLN   CA  C    sing N N 128 
GLN   CA  CB   sing N N 129 
GLN   CA  HA   sing N N 130 
GLN   C   O    doub N N 131 
GLN   C   OXT  sing N N 132 
GLN   CB  CG   sing N N 133 
GLN   CB  HB2  sing N N 134 
GLN   CB  HB3  sing N N 135 
GLN   CG  CD   sing N N 136 
GLN   CG  HG2  sing N N 137 
GLN   CG  HG3  sing N N 138 
GLN   CD  OE1  doub N N 139 
GLN   CD  NE2  sing N N 140 
GLN   NE2 HE21 sing N N 141 
GLN   NE2 HE22 sing N N 142 
GLN   OXT HXT  sing N N 143 
GLU   N   CA   sing N N 144 
GLU   N   H    sing N N 145 
GLU   N   H2   sing N N 146 
GLU   CA  C    sing N N 147 
GLU   CA  CB   sing N N 148 
GLU   CA  HA   sing N N 149 
GLU   C   O    doub N N 150 
GLU   C   OXT  sing N N 151 
GLU   CB  CG   sing N N 152 
GLU   CB  HB2  sing N N 153 
GLU   CB  HB3  sing N N 154 
GLU   CG  CD   sing N N 155 
GLU   CG  HG2  sing N N 156 
GLU   CG  HG3  sing N N 157 
GLU   CD  OE1  doub N N 158 
GLU   CD  OE2  sing N N 159 
GLU   OE2 HE2  sing N N 160 
GLU   OXT HXT  sing N N 161 
GLY   N   CA   sing N N 162 
GLY   N   H    sing N N 163 
GLY   N   H2   sing N N 164 
GLY   CA  C    sing N N 165 
GLY   CA  HA2  sing N N 166 
GLY   CA  HA3  sing N N 167 
GLY   C   O    doub N N 168 
GLY   C   OXT  sing N N 169 
GLY   OXT HXT  sing N N 170 
HIS   N   CA   sing N N 171 
HIS   N   H    sing N N 172 
HIS   N   H2   sing N N 173 
HIS   CA  C    sing N N 174 
HIS   CA  CB   sing N N 175 
HIS   CA  HA   sing N N 176 
HIS   C   O    doub N N 177 
HIS   C   OXT  sing N N 178 
HIS   CB  CG   sing N N 179 
HIS   CB  HB2  sing N N 180 
HIS   CB  HB3  sing N N 181 
HIS   CG  ND1  sing Y N 182 
HIS   CG  CD2  doub Y N 183 
HIS   ND1 CE1  doub Y N 184 
HIS   ND1 HD1  sing N N 185 
HIS   CD2 NE2  sing Y N 186 
HIS   CD2 HD2  sing N N 187 
HIS   CE1 NE2  sing Y N 188 
HIS   CE1 HE1  sing N N 189 
HIS   NE2 HE2  sing N N 190 
HIS   OXT HXT  sing N N 191 
HOH   O   H1   sing N N 192 
HOH   O   H2   sing N N 193 
ILE   N   CA   sing N N 194 
ILE   N   H    sing N N 195 
ILE   N   H2   sing N N 196 
ILE   CA  C    sing N N 197 
ILE   CA  CB   sing N N 198 
ILE   CA  HA   sing N N 199 
ILE   C   O    doub N N 200 
ILE   C   OXT  sing N N 201 
ILE   CB  CG1  sing N N 202 
ILE   CB  CG2  sing N N 203 
ILE   CB  HB   sing N N 204 
ILE   CG1 CD1  sing N N 205 
ILE   CG1 HG12 sing N N 206 
ILE   CG1 HG13 sing N N 207 
ILE   CG2 HG21 sing N N 208 
ILE   CG2 HG22 sing N N 209 
ILE   CG2 HG23 sing N N 210 
ILE   CD1 HD11 sing N N 211 
ILE   CD1 HD12 sing N N 212 
ILE   CD1 HD13 sing N N 213 
ILE   OXT HXT  sing N N 214 
LEU   N   CA   sing N N 215 
LEU   N   H    sing N N 216 
LEU   N   H2   sing N N 217 
LEU   CA  C    sing N N 218 
LEU   CA  CB   sing N N 219 
LEU   CA  HA   sing N N 220 
LEU   C   O    doub N N 221 
LEU   C   OXT  sing N N 222 
LEU   CB  CG   sing N N 223 
LEU   CB  HB2  sing N N 224 
LEU   CB  HB3  sing N N 225 
LEU   CG  CD1  sing N N 226 
LEU   CG  CD2  sing N N 227 
LEU   CG  HG   sing N N 228 
LEU   CD1 HD11 sing N N 229 
LEU   CD1 HD12 sing N N 230 
LEU   CD1 HD13 sing N N 231 
LEU   CD2 HD21 sing N N 232 
LEU   CD2 HD22 sing N N 233 
LEU   CD2 HD23 sing N N 234 
LEU   OXT HXT  sing N N 235 
LYS   N   CA   sing N N 236 
LYS   N   H    sing N N 237 
LYS   N   H2   sing N N 238 
LYS   CA  C    sing N N 239 
LYS   CA  CB   sing N N 240 
LYS   CA  HA   sing N N 241 
LYS   C   O    doub N N 242 
LYS   C   OXT  sing N N 243 
LYS   CB  CG   sing N N 244 
LYS   CB  HB2  sing N N 245 
LYS   CB  HB3  sing N N 246 
LYS   CG  CD   sing N N 247 
LYS   CG  HG2  sing N N 248 
LYS   CG  HG3  sing N N 249 
LYS   CD  CE   sing N N 250 
LYS   CD  HD2  sing N N 251 
LYS   CD  HD3  sing N N 252 
LYS   CE  NZ   sing N N 253 
LYS   CE  HE2  sing N N 254 
LYS   CE  HE3  sing N N 255 
LYS   NZ  HZ1  sing N N 256 
LYS   NZ  HZ2  sing N N 257 
LYS   NZ  HZ3  sing N N 258 
LYS   OXT HXT  sing N N 259 
MES   O1  C2   sing N N 260 
MES   O1  C6   sing N N 261 
MES   C2  C3   sing N N 262 
MES   C2  H21  sing N N 263 
MES   C2  H22  sing N N 264 
MES   C3  N4   sing N N 265 
MES   C3  H31  sing N N 266 
MES   C3  H32  sing N N 267 
MES   N4  C5   sing N N 268 
MES   N4  C7   sing N N 269 
MES   N4  HN4  sing N N 270 
MES   C5  C6   sing N N 271 
MES   C5  H51  sing N N 272 
MES   C5  H52  sing N N 273 
MES   C6  H61  sing N N 274 
MES   C6  H62  sing N N 275 
MES   C7  C8   sing N N 276 
MES   C7  H71  sing N N 277 
MES   C7  H72  sing N N 278 
MES   C8  S    sing N N 279 
MES   C8  H81  sing N N 280 
MES   C8  H82  sing N N 281 
MES   S   O1S  doub N N 282 
MES   S   O2S  doub N N 283 
MES   S   O3S  sing N N 284 
MET   N   CA   sing N N 285 
MET   N   H    sing N N 286 
MET   N   H2   sing N N 287 
MET   CA  C    sing N N 288 
MET   CA  CB   sing N N 289 
MET   CA  HA   sing N N 290 
MET   C   O    doub N N 291 
MET   C   OXT  sing N N 292 
MET   CB  CG   sing N N 293 
MET   CB  HB2  sing N N 294 
MET   CB  HB3  sing N N 295 
MET   CG  SD   sing N N 296 
MET   CG  HG2  sing N N 297 
MET   CG  HG3  sing N N 298 
MET   SD  CE   sing N N 299 
MET   CE  HE1  sing N N 300 
MET   CE  HE2  sing N N 301 
MET   CE  HE3  sing N N 302 
MET   OXT HXT  sing N N 303 
PEG   C1  O1   sing N N 304 
PEG   C1  C2   sing N N 305 
PEG   C1  H11  sing N N 306 
PEG   C1  H12  sing N N 307 
PEG   O1  HO1  sing N N 308 
PEG   C2  O2   sing N N 309 
PEG   C2  H21  sing N N 310 
PEG   C2  H22  sing N N 311 
PEG   O2  C3   sing N N 312 
PEG   C3  C4   sing N N 313 
PEG   C3  H31  sing N N 314 
PEG   C3  H32  sing N N 315 
PEG   C4  O4   sing N N 316 
PEG   C4  H41  sing N N 317 
PEG   C4  H42  sing N N 318 
PEG   O4  HO4  sing N N 319 
PHE   N   CA   sing N N 320 
PHE   N   H    sing N N 321 
PHE   N   H2   sing N N 322 
PHE   CA  C    sing N N 323 
PHE   CA  CB   sing N N 324 
PHE   CA  HA   sing N N 325 
PHE   C   O    doub N N 326 
PHE   C   OXT  sing N N 327 
PHE   CB  CG   sing N N 328 
PHE   CB  HB2  sing N N 329 
PHE   CB  HB3  sing N N 330 
PHE   CG  CD1  doub Y N 331 
PHE   CG  CD2  sing Y N 332 
PHE   CD1 CE1  sing Y N 333 
PHE   CD1 HD1  sing N N 334 
PHE   CD2 CE2  doub Y N 335 
PHE   CD2 HD2  sing N N 336 
PHE   CE1 CZ   doub Y N 337 
PHE   CE1 HE1  sing N N 338 
PHE   CE2 CZ   sing Y N 339 
PHE   CE2 HE2  sing N N 340 
PHE   CZ  HZ   sing N N 341 
PHE   OXT HXT  sing N N 342 
PO4   P   O1   doub N N 343 
PO4   P   O2   sing N N 344 
PO4   P   O3   sing N N 345 
PO4   P   O4   sing N N 346 
PRO   N   CA   sing N N 347 
PRO   N   CD   sing N N 348 
PRO   N   H    sing N N 349 
PRO   CA  C    sing N N 350 
PRO   CA  CB   sing N N 351 
PRO   CA  HA   sing N N 352 
PRO   C   O    doub N N 353 
PRO   C   OXT  sing N N 354 
PRO   CB  CG   sing N N 355 
PRO   CB  HB2  sing N N 356 
PRO   CB  HB3  sing N N 357 
PRO   CG  CD   sing N N 358 
PRO   CG  HG2  sing N N 359 
PRO   CG  HG3  sing N N 360 
PRO   CD  HD2  sing N N 361 
PRO   CD  HD3  sing N N 362 
PRO   OXT HXT  sing N N 363 
SER   N   CA   sing N N 364 
SER   N   H    sing N N 365 
SER   N   H2   sing N N 366 
SER   CA  C    sing N N 367 
SER   CA  CB   sing N N 368 
SER   CA  HA   sing N N 369 
SER   C   O    doub N N 370 
SER   C   OXT  sing N N 371 
SER   CB  OG   sing N N 372 
SER   CB  HB2  sing N N 373 
SER   CB  HB3  sing N N 374 
SER   OG  HG   sing N N 375 
SER   OXT HXT  sing N N 376 
THR   N   CA   sing N N 377 
THR   N   H    sing N N 378 
THR   N   H2   sing N N 379 
THR   CA  C    sing N N 380 
THR   CA  CB   sing N N 381 
THR   CA  HA   sing N N 382 
THR   C   O    doub N N 383 
THR   C   OXT  sing N N 384 
THR   CB  OG1  sing N N 385 
THR   CB  CG2  sing N N 386 
THR   CB  HB   sing N N 387 
THR   OG1 HG1  sing N N 388 
THR   CG2 HG21 sing N N 389 
THR   CG2 HG22 sing N N 390 
THR   CG2 HG23 sing N N 391 
THR   OXT HXT  sing N N 392 
TRP   N   CA   sing N N 393 
TRP   N   H    sing N N 394 
TRP   N   H2   sing N N 395 
TRP   CA  C    sing N N 396 
TRP   CA  CB   sing N N 397 
TRP   CA  HA   sing N N 398 
TRP   C   O    doub N N 399 
TRP   C   OXT  sing N N 400 
TRP   CB  CG   sing N N 401 
TRP   CB  HB2  sing N N 402 
TRP   CB  HB3  sing N N 403 
TRP   CG  CD1  doub Y N 404 
TRP   CG  CD2  sing Y N 405 
TRP   CD1 NE1  sing Y N 406 
TRP   CD1 HD1  sing N N 407 
TRP   CD2 CE2  doub Y N 408 
TRP   CD2 CE3  sing Y N 409 
TRP   NE1 CE2  sing Y N 410 
TRP   NE1 HE1  sing N N 411 
TRP   CE2 CZ2  sing Y N 412 
TRP   CE3 CZ3  doub Y N 413 
TRP   CE3 HE3  sing N N 414 
TRP   CZ2 CH2  doub Y N 415 
TRP   CZ2 HZ2  sing N N 416 
TRP   CZ3 CH2  sing Y N 417 
TRP   CZ3 HZ3  sing N N 418 
TRP   CH2 HH2  sing N N 419 
TRP   OXT HXT  sing N N 420 
TYR   N   CA   sing N N 421 
TYR   N   H    sing N N 422 
TYR   N   H2   sing N N 423 
TYR   CA  C    sing N N 424 
TYR   CA  CB   sing N N 425 
TYR   CA  HA   sing N N 426 
TYR   C   O    doub N N 427 
TYR   C   OXT  sing N N 428 
TYR   CB  CG   sing N N 429 
TYR   CB  HB2  sing N N 430 
TYR   CB  HB3  sing N N 431 
TYR   CG  CD1  doub Y N 432 
TYR   CG  CD2  sing Y N 433 
TYR   CD1 CE1  sing Y N 434 
TYR   CD1 HD1  sing N N 435 
TYR   CD2 CE2  doub Y N 436 
TYR   CD2 HD2  sing N N 437 
TYR   CE1 CZ   doub Y N 438 
TYR   CE1 HE1  sing N N 439 
TYR   CE2 CZ   sing Y N 440 
TYR   CE2 HE2  sing N N 441 
TYR   CZ  OH   sing N N 442 
TYR   OH  HH   sing N N 443 
TYR   OXT HXT  sing N N 444 
VAL   N   CA   sing N N 445 
VAL   N   H    sing N N 446 
VAL   N   H2   sing N N 447 
VAL   CA  C    sing N N 448 
VAL   CA  CB   sing N N 449 
VAL   CA  HA   sing N N 450 
VAL   C   O    doub N N 451 
VAL   C   OXT  sing N N 452 
VAL   CB  CG1  sing N N 453 
VAL   CB  CG2  sing N N 454 
VAL   CB  HB   sing N N 455 
VAL   CG1 HG11 sing N N 456 
VAL   CG1 HG12 sing N N 457 
VAL   CG1 HG13 sing N N 458 
VAL   CG2 HG21 sing N N 459 
VAL   CG2 HG22 sing N N 460 
VAL   CG2 HG23 sing N N 461 
VAL   OXT HXT  sing N N 462 
# 
_pdbx_audit_support.ordinal                1 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)' 
_pdbx_audit_support.grant_number           U19AI171292 
_pdbx_audit_support.country                'United States' 
# 
_pdbx_deposit_group.group_id            G_1002341 
_pdbx_deposit_group.group_description   
'Crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_title         
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_type          'changed state' 
# 
_atom_sites.entry_id                    7I2E 
_atom_sites.fract_transf_matrix[1][1]   0.012122 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.008558 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006715 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
# 
loop_
_atom_type.symbol 
C  
CL 
N  
O  
P  
S  
ZN 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ASN   A 1 10  ? -12.780 -6.236  -12.323 1.00 102.57 ? 273  ASN   A N   1 
ATOM   2    C  CA  . ASN   A 1 10  ? -12.823 -6.890  -10.985 1.00 96.49  ? 273  ASN   A CA  1 
ATOM   3    C  C   . ASN   A 1 10  ? -14.212 -6.620  -10.379 1.00 98.22  ? 273  ASN   A C   1 
ATOM   4    O  O   . ASN   A 1 10  ? -15.215 -7.045  -11.017 1.00 82.76  ? 273  ASN   A O   1 
ATOM   5    C  CB  . ASN   A 1 10  ? -11.615 -6.472  -10.125 1.00 96.02  ? 273  ASN   A CB  1 
ATOM   6    C  CG  . ASN   A 1 10  ? -11.236 -7.488  -9.063  1.00 92.60  ? 273  ASN   A CG  1 
ATOM   7    O  OD1 . ASN   A 1 10  ? -12.104 -8.112  -8.461  1.00 92.41  ? 273  ASN   A OD1 1 
ATOM   8    N  ND2 . ASN   A 1 10  ? -9.947  -7.680  -8.827  1.00 83.42  ? 273  ASN   A ND2 1 
ATOM   9    N  N   . LEU   A 1 11  ? -14.279 -5.880  -9.257  1.00 92.06  ? 274  LEU   A N   1 
ATOM   10   C  CA  . LEU   A 1 11  ? -15.348 -6.017  -8.223  1.00 81.94  ? 274  LEU   A CA  1 
ATOM   11   C  C   . LEU   A 1 11  ? -16.702 -5.536  -8.753  1.00 73.48  ? 274  LEU   A C   1 
ATOM   12   O  O   . LEU   A 1 11  ? -17.722 -5.939  -8.179  1.00 69.96  ? 274  LEU   A O   1 
ATOM   13   C  CB  . LEU   A 1 11  ? -14.938 -5.284  -6.940  1.00 88.18  ? 274  LEU   A CB  1 
ATOM   14   C  CG  . LEU   A 1 11  ? -14.448 -6.192  -5.808  1.00 93.72  ? 274  LEU   A CG  1 
ATOM   15   C  CD1 . LEU   A 1 11  ? -13.591 -5.433  -4.804  1.00 94.39  ? 274  LEU   A CD1 1 
ATOM   16   C  CD2 . LEU   A 1 11  ? -15.621 -6.860  -5.105  1.00 93.91  ? 274  LEU   A CD2 1 
ATOM   17   N  N   . ASP   A 1 12  ? -16.727 -4.741  -9.820  1.00 62.99  ? 275  ASP   A N   1 
ATOM   18   C  CA  . ASP   A 1 12  ? -17.997 -4.280  -10.442 1.00 81.46  ? 275  ASP   A CA  1 
ATOM   19   C  C   . ASP   A 1 12  ? -18.764 -5.479  -11.026 1.00 84.87  ? 275  ASP   A C   1 
ATOM   20   O  O   . ASP   A 1 12  ? -19.997 -5.452  -10.932 1.00 88.51  ? 275  ASP   A O   1 
ATOM   21   C  CB  . ASP   A 1 12  ? -17.751 -3.193  -11.494 1.00 89.33  ? 275  ASP   A CB  1 
ATOM   22   C  CG  . ASP   A 1 12  ? -16.808 -3.634  -12.597 1.00 96.31  ? 275  ASP   A CG  1 
ATOM   23   O  OD1 . ASP   A 1 12  ? -15.868 -4.411  -12.292 1.00 100.75 ? 275  ASP   A OD1 1 
ATOM   24   O  OD2 . ASP   A 1 12  ? -17.037 -3.224  -13.750 1.00 108.77 ? 275  ASP   A OD2 1 
ATOM   25   N  N   . ILE   A 1 13  ? -18.090 -6.492  -11.601 1.00 77.49  ? 276  ILE   A N   1 
ATOM   26   C  CA  . ILE   A 1 13  ? -18.777 -7.664  -12.237 1.00 63.03  ? 276  ILE   A CA  1 
ATOM   27   C  C   . ILE   A 1 13  ? -19.123 -8.718  -11.172 1.00 55.45  ? 276  ILE   A C   1 
ATOM   28   O  O   . ILE   A 1 13  ? -20.204 -9.314  -11.282 1.00 50.73  ? 276  ILE   A O   1 
ATOM   29   C  CB  . ILE   A 1 13  ? -17.956 -8.230  -13.416 1.00 71.86  ? 276  ILE   A CB  1 
ATOM   30   C  CG1 . ILE   A 1 13  ? -17.891 -7.233  -14.581 1.00 62.89  ? 276  ILE   A CG1 1 
ATOM   31   C  CG2 . ILE   A 1 13  ? -18.507 -9.583  -13.864 1.00 71.10  ? 276  ILE   A CG2 1 
ATOM   32   C  CD1 . ILE   A 1 13  ? -16.955 -7.632  -15.713 1.00 60.38  ? 276  ILE   A CD1 1 
ATOM   33   N  N   . ILE   A 1 14  ? -18.280 -8.925  -10.154 1.00 56.33  ? 277  ILE   A N   1 
ATOM   34   C  CA  . ILE   A 1 14  ? -18.489 -9.994  -9.127  1.00 64.19  ? 277  ILE   A CA  1 
ATOM   35   C  C   . ILE   A 1 14  ? -19.106 -9.484  -7.803  1.00 67.74  ? 277  ILE   A C   1 
ATOM   36   O  O   . ILE   A 1 14  ? -19.678 -10.316 -7.063  1.00 65.85  ? 277  ILE   A O   1 
ATOM   37   C  CB  . ILE   A 1 14  ? -17.163 -10.734 -8.858  1.00 67.96  ? 277  ILE   A CB  1 
ATOM   38   C  CG1 . ILE   A 1 14  ? -16.035 -9.773  -8.466  1.00 65.88  ? 277  ILE   A CG1 1 
ATOM   39   C  CG2 . ILE   A 1 14  ? -16.779 -11.596 -10.052 1.00 64.82  ? 277  ILE   A CG2 1 
ATOM   40   C  CD1 . ILE   A 1 14  ? -14.838 -10.471 -7.864  1.00 70.51  ? 277  ILE   A CD1 1 
ATOM   41   N  N   . GLY   A 1 15  ? -18.966 -8.184  -7.511  0.25 69.90  ? 278  GLY   A N   1 
ATOM   42   C  CA  . GLY   A 1 15  ? -19.355 -7.556  -6.231  0.25 70.00  ? 278  GLY   A CA  1 
ATOM   43   C  C   . GLY   A 1 15  ? -20.825 -7.757  -5.902  0.25 70.52  ? 278  GLY   A C   1 
ATOM   44   O  O   . GLY   A 1 15  ? -21.141 -7.926  -4.709  0.25 71.44  ? 278  GLY   A O   1 
ATOM   45   N  N   . LYS   A 1 16  ? -21.691 -7.743  -6.921  0.25 71.48  ? 279  LYS   A N   1 
ATOM   46   C  CA  . LYS   A 1 16  ? -23.168 -7.877  -6.783  0.25 71.82  ? 279  LYS   A CA  1 
ATOM   47   C  C   . LYS   A 1 16  ? -23.499 -9.268  -6.223  0.25 71.69  ? 279  LYS   A C   1 
ATOM   48   O  O   . LYS   A 1 16  ? -24.354 -9.349  -5.319  0.25 71.27  ? 279  LYS   A O   1 
ATOM   49   C  CB  . LYS   A 1 16  ? -23.834 -7.603  -8.136  0.25 73.58  ? 279  LYS   A CB  1 
ATOM   50   C  CG  . LYS   A 1 16  ? -25.331 -7.324  -8.094  0.25 74.70  ? 279  LYS   A CG  1 
ATOM   51   C  CD  . LYS   A 1 16  ? -25.798 -6.369  -9.180  0.25 75.24  ? 279  LYS   A CD  1 
ATOM   52   C  CE  . LYS   A 1 16  ? -27.190 -6.673  -9.692  0.25 76.52  ? 279  LYS   A CE  1 
ATOM   53   N  NZ  . LYS   A 1 16  ? -28.186 -6.731  -8.595  0.25 77.35  ? 279  LYS   A NZ  1 
ATOM   54   N  N   . ARG   A 1 17  ? -22.840 -10.314 -6.738  0.25 71.07  ? 280  ARG   A N   1 
ATOM   55   C  CA  . ARG   A 1 17  ? -22.930 -11.711 -6.223  0.25 71.09  ? 280  ARG   A CA  1 
ATOM   56   C  C   . ARG   A 1 17  ? -22.377 -11.769 -4.794  0.25 70.66  ? 280  ARG   A C   1 
ATOM   57   O  O   . ARG   A 1 17  ? -22.989 -12.456 -3.953  0.25 70.51  ? 280  ARG   A O   1 
ATOM   58   C  CB  . ARG   A 1 17  ? -22.158 -12.688 -7.118  0.25 70.58  ? 280  ARG   A CB  1 
ATOM   59   C  CG  . ARG   A 1 17  ? -23.019 -13.425 -8.134  0.25 69.95  ? 280  ARG   A CG  1 
ATOM   60   C  CD  . ARG   A 1 17  ? -22.185 -14.120 -9.193  0.25 67.54  ? 280  ARG   A CD  1 
ATOM   61   N  NE  . ARG   A 1 17  ? -21.554 -13.165 -10.093 0.25 66.09  ? 280  ARG   A NE  1 
ATOM   62   C  CZ  . ARG   A 1 17  ? -20.735 -13.481 -11.092 0.25 65.42  ? 280  ARG   A CZ  1 
ATOM   63   N  NH1 . ARG   A 1 17  ? -20.425 -14.745 -11.335 0.25 64.83  ? 280  ARG   A NH1 1 
ATOM   64   N  NH2 . ARG   A 1 17  ? -20.225 -12.524 -11.848 0.25 64.87  ? 280  ARG   A NH2 1 
ATOM   65   N  N   . ILE   A 1 18  ? -21.253 -11.089 -4.546  0.25 71.76  ? 281  ILE   A N   1 
ATOM   66   C  CA  . ILE   A 1 18  ? -20.538 -11.076 -3.234  0.25 74.05  ? 281  ILE   A CA  1 
ATOM   67   C  C   . ILE   A 1 18  ? -21.410 -10.346 -2.202  0.25 74.65  ? 281  ILE   A C   1 
ATOM   68   O  O   . ILE   A 1 18  ? -21.558 -10.881 -1.084  0.25 75.27  ? 281  ILE   A O   1 
ATOM   69   C  CB  . ILE   A 1 18  ? -19.132 -10.453 -3.379  0.25 74.99  ? 281  ILE   A CB  1 
ATOM   70   C  CG1 . ILE   A 1 18  ? -18.221 -11.328 -4.246  0.25 76.23  ? 281  ILE   A CG1 1 
ATOM   71   C  CG2 . ILE   A 1 18  ? -18.508 -10.181 -2.017  0.25 75.47  ? 281  ILE   A CG2 1 
ATOM   72   C  CD1 . ILE   A 1 18  ? -17.056 -10.589 -4.860  0.25 76.97  ? 281  ILE   A CD1 1 
ATOM   73   N  N   . GLU   A 1 19  ? -21.969 -9.185  -2.572  0.25 73.95  ? 282  GLU   A N   1 
ATOM   74   C  CA  . GLU   A 1 19  ? -22.892 -8.377  -1.724  0.25 75.18  ? 282  GLU   A CA  1 
ATOM   75   C  C   . GLU   A 1 19  ? -24.018 -9.271  -1.195  0.25 75.02  ? 282  GLU   A C   1 
ATOM   76   O  O   . GLU   A 1 19  ? -24.227 -9.284  0.032   0.25 76.09  ? 282  GLU   A O   1 
ATOM   77   C  CB  . GLU   A 1 19  ? -23.495 -7.204  -2.503  0.25 76.49  ? 282  GLU   A CB  1 
ATOM   78   C  CG  . GLU   A 1 19  ? -22.714 -5.907  -2.374  0.25 77.44  ? 282  GLU   A CG  1 
ATOM   79   C  CD  . GLU   A 1 19  ? -23.461 -4.669  -2.847  0.25 78.66  ? 282  GLU   A CD  1 
ATOM   80   O  OE1 . GLU   A 1 19  ? -24.364 -4.810  -3.702  0.25 79.16  ? 282  GLU   A OE1 1 
ATOM   81   O  OE2 . GLU   A 1 19  ? -23.144 -3.564  -2.359  0.25 75.22  ? 282  GLU   A OE2 1 
ATOM   82   N  N   . LYS   A 1 20  ? -24.704 -9.987  -2.093  0.25 73.88  ? 283  LYS   A N   1 
ATOM   83   C  CA  . LYS   A 1 20  ? -25.896 -10.825 -1.782  0.25 73.40  ? 283  LYS   A CA  1 
ATOM   84   C  C   . LYS   A 1 20  ? -25.522 -11.922 -0.777  0.25 74.79  ? 283  LYS   A C   1 
ATOM   85   O  O   . LYS   A 1 20  ? -26.351 -12.201 0.110   0.25 76.78  ? 283  LYS   A O   1 
ATOM   86   C  CB  . LYS   A 1 20  ? -26.481 -11.442 -3.056  0.25 72.47  ? 283  LYS   A CB  1 
ATOM   87   C  CG  . LYS   A 1 20  ? -27.617 -12.435 -2.832  0.25 71.26  ? 283  LYS   A CG  1 
ATOM   88   C  CD  . LYS   A 1 20  ? -28.509 -12.626 -4.045  0.25 71.36  ? 283  LYS   A CD  1 
ATOM   89   C  CE  . LYS   A 1 20  ? -29.767 -13.417 -3.754  0.25 69.71  ? 283  LYS   A CE  1 
ATOM   90   N  NZ  . LYS   A 1 20  ? -29.464 -14.815 -3.366  0.25 69.36  ? 283  LYS   A NZ  1 
ATOM   91   N  N   . ILE   A 1 21  ? -24.333 -12.521 -0.916  1.00 73.80  ? 284  ILE   A N   1 
ATOM   92   C  CA  . ILE   A 1 21  ? -23.871 -13.618 -0.004  1.00 80.77  ? 284  ILE   A CA  1 
ATOM   93   C  C   . ILE   A 1 21  ? -23.525 -13.018 1.373   1.00 76.96  ? 284  ILE   A C   1 
ATOM   94   O  O   . ILE   A 1 21  ? -23.941 -13.625 2.392   1.00 65.65  ? 284  ILE   A O   1 
ATOM   95   C  CB  . ILE   A 1 21  ? -22.684 -14.423 -0.579  1.00 83.20  ? 284  ILE   A CB  1 
ATOM   96   C  CG1 . ILE   A 1 21  ? -23.002 -15.055 -1.935  1.00 87.80  ? 284  ILE   A CG1 1 
ATOM   97   C  CG2 . ILE   A 1 21  ? -22.220 -15.483 0.418   1.00 77.72  ? 284  ILE   A CG2 1 
ATOM   98   C  CD1 . ILE   A 1 21  ? -21.772 -15.284 -2.810  1.00 81.06  ? 284  ILE   A CD1 1 
ATOM   99   N  N   . LYS   A 1 22  ? -22.762 -11.915 1.392   1.00 77.00  ? 285  LYS   A N   1 
ATOM   100  C  CA  . LYS   A 1 22  ? -22.457 -11.085 2.596   1.00 89.89  ? 285  LYS   A CA  1 
ATOM   101  C  C   . LYS   A 1 22  ? -23.694 -11.026 3.514   1.00 88.53  ? 285  LYS   A C   1 
ATOM   102  O  O   . LYS   A 1 22  ? -23.581 -11.404 4.691   1.00 86.52  ? 285  LYS   A O   1 
ATOM   103  C  CB  . LYS   A 1 22  ? -22.029 -9.677  2.161   1.00 100.45 ? 285  LYS   A CB  1 
ATOM   104  C  CG  . LYS   A 1 22  ? -20.802 -9.092  2.848   1.00 104.27 ? 285  LYS   A CG  1 
ATOM   105  C  CD  . LYS   A 1 22  ? -20.537 -7.639  2.473   1.00 110.63 ? 285  LYS   A CD  1 
ATOM   106  C  CE  . LYS   A 1 22  ? -19.566 -6.952  3.412   1.00 118.37 ? 285  LYS   A CE  1 
ATOM   107  N  NZ  . LYS   A 1 22  ? -19.656 -5.476  3.311   1.00 119.15 ? 285  LYS   A NZ  1 
ATOM   108  N  N   . GLN   A 1 23  ? -24.849 -10.621 2.975   1.00 88.47  ? 286  GLN   A N   1 
ATOM   109  C  CA  . GLN   A 1 23  ? -26.089 -10.319 3.744   1.00 90.54  ? 286  GLN   A CA  1 
ATOM   110  C  C   . GLN   A 1 23  ? -26.789 -11.571 4.300   1.00 90.31  ? 286  GLN   A C   1 
ATOM   111  O  O   . GLN   A 1 23  ? -27.303 -11.506 5.416   1.00 107.64 ? 286  GLN   A O   1 
ATOM   112  C  CB  . GLN   A 1 23  ? -27.080 -9.545  2.881   1.00 82.93  ? 286  GLN   A CB  1 
ATOM   113  C  CG  . GLN   A 1 23  ? -26.552 -8.184  2.467   1.00 85.39  ? 286  GLN   A CG  1 
ATOM   114  C  CD  . GLN   A 1 23  ? -27.540 -7.507  1.558   1.00 93.19  ? 286  GLN   A CD  1 
ATOM   115  O  OE1 . GLN   A 1 23  ? -28.738 -7.776  1.620   1.00 103.56 ? 286  GLN   A OE1 1 
ATOM   116  N  NE2 . GLN   A 1 23  ? -27.041 -6.636  0.696   1.00 99.72  ? 286  GLN   A NE2 1 
ATOM   117  N  N   . GLU   A 1 24  ? -26.816 -12.661 3.525   0.25 92.54  ? 287  GLU   A N   1 
ATOM   118  C  CA  . GLU   A 1 24  ? -27.466 -13.947 3.904   0.25 93.97  ? 287  GLU   A CA  1 
ATOM   119  C  C   . GLU   A 1 24  ? -26.782 -14.531 5.148   0.25 94.53  ? 287  GLU   A C   1 
ATOM   120  O  O   . GLU   A 1 24  ? -27.424 -15.346 5.841   0.25 93.29  ? 287  GLU   A O   1 
ATOM   121  C  CB  . GLU   A 1 24  ? -27.407 -14.950 2.750   0.25 96.37  ? 287  GLU   A CB  1 
ATOM   122  C  CG  . GLU   A 1 24  ? -28.274 -14.572 1.563   0.25 98.47  ? 287  GLU   A CG  1 
ATOM   123  C  CD  . GLU   A 1 24  ? -27.991 -15.377 0.305   0.25 100.20 ? 287  GLU   A CD  1 
ATOM   124  O  OE1 . GLU   A 1 24  ? -27.357 -14.826 -0.614  0.25 101.87 ? 287  GLU   A OE1 1 
ATOM   125  O  OE2 . GLU   A 1 24  ? -28.406 -16.553 0.249   0.25 99.34  ? 287  GLU   A OE2 1 
ATOM   126  N  N   . HIS   A 1 25  ? -25.528 -14.137 5.405   1.00 94.63  ? 288  HIS   A N   1 
ATOM   127  C  CA  . HIS   A 1 25  ? -24.722 -14.606 6.568   1.00 99.67  ? 288  HIS   A CA  1 
ATOM   128  C  C   . HIS   A 1 25  ? -24.060 -13.398 7.256   1.00 109.96 ? 288  HIS   A C   1 
ATOM   129  O  O   . HIS   A 1 25  ? -22.833 -13.439 7.518   1.00 118.71 ? 288  HIS   A O   1 
ATOM   130  C  CB  . HIS   A 1 25  ? -23.711 -15.670 6.097   1.00 91.03  ? 288  HIS   A CB  1 
ATOM   131  C  CG  . HIS   A 1 25  ? -24.320 -16.794 5.323   1.00 81.80  ? 288  HIS   A CG  1 
ATOM   132  N  ND1 . HIS   A 1 25  ? -24.886 -17.901 5.940   1.00 88.19  ? 288  HIS   A ND1 1 
ATOM   133  C  CD2 . HIS   A 1 25  ? -24.452 -16.994 3.992   1.00 72.30  ? 288  HIS   A CD2 1 
ATOM   134  C  CE1 . HIS   A 1 25  ? -25.341 -18.733 5.019   1.00 83.63  ? 288  HIS   A CE1 1 
ATOM   135  N  NE2 . HIS   A 1 25  ? -25.089 -18.195 3.817   1.00 69.71  ? 288  HIS   A NE2 1 
ATOM   136  N  N   . GLU   A 1 26  ? -24.857 -12.363 7.548   0.25 108.32 ? 289  GLU   A N   1 
ATOM   137  C  CA  . GLU   A 1 26  ? -24.418 -11.091 8.190   0.25 107.97 ? 289  GLU   A CA  1 
ATOM   138  C  C   . GLU   A 1 26  ? -23.833 -11.384 9.580   0.25 106.60 ? 289  GLU   A C   1 
ATOM   139  O  O   . GLU   A 1 26  ? -22.904 -10.660 9.992   0.25 104.77 ? 289  GLU   A O   1 
ATOM   140  C  CB  . GLU   A 1 26  ? -25.597 -10.116 8.285   0.25 107.13 ? 289  GLU   A CB  1 
ATOM   141  C  CG  . GLU   A 1 26  ? -25.223 -8.729  8.785   0.25 106.23 ? 289  GLU   A CG  1 
ATOM   142  C  CD  . GLU   A 1 26  ? -24.351 -7.918  7.841   0.25 106.41 ? 289  GLU   A CD  1 
ATOM   143  O  OE1 . GLU   A 1 26  ? -23.335 -7.365  8.307   0.25 106.33 ? 289  GLU   A OE1 1 
ATOM   144  O  OE2 . GLU   A 1 26  ? -24.696 -7.831  6.645   0.25 106.56 ? 289  GLU   A OE2 1 
ATOM   145  N  N   . THR   A 1 27  ? -24.357 -12.408 10.264  0.25 104.93 ? 290  THR   A N   1 
ATOM   146  C  CA  . THR   A 1 27  ? -23.979 -12.806 11.648  0.25 103.45 ? 290  THR   A CA  1 
ATOM   147  C  C   . THR   A 1 27  ? -22.546 -13.359 11.691  0.25 100.62 ? 290  THR   A C   1 
ATOM   148  O  O   . THR   A 1 27  ? -21.901 -13.193 12.745  0.25 101.64 ? 290  THR   A O   1 
ATOM   149  C  CB  . THR   A 1 27  ? -24.975 -13.826 12.222  0.25 104.17 ? 290  THR   A CB  1 
ATOM   150  O  OG1 . THR   A 1 27  ? -25.300 -14.769 11.199  0.25 105.52 ? 290  THR   A OG1 1 
ATOM   151  C  CG2 . THR   A 1 27  ? -26.244 -13.184 12.741  0.25 104.10 ? 290  THR   A CG2 1 
ATOM   152  N  N   . SER   A 1 28  ? -22.065 -13.976 10.602  0.25 96.28  ? 291  SER   A N   1 
ATOM   153  C  CA  . SER   A 1 28  ? -20.847 -14.834 10.585  0.25 90.61  ? 291  SER   A CA  1 
ATOM   154  C  C   . SER   A 1 28  ? -19.748 -14.284 9.662   0.25 85.90  ? 291  SER   A C   1 
ATOM   155  O  O   . SER   A 1 28  ? -18.719 -14.973 9.533   0.25 83.56  ? 291  SER   A O   1 
ATOM   156  C  CB  . SER   A 1 28  ? -21.212 -16.244 10.195  0.25 91.55  ? 291  SER   A CB  1 
ATOM   157  O  OG  . SER   A 1 28  ? -22.165 -16.789 11.095  0.25 91.98  ? 291  SER   A OG  1 
ATOM   158  N  N   . TRP   A 1 29  ? -19.926 -13.100 9.063   0.25 82.01  ? 292  TRP   A N   1 
ATOM   159  C  CA  . TRP   A 1 29  ? -19.011 -12.562 8.015   0.25 80.80  ? 292  TRP   A CA  1 
ATOM   160  C  C   . TRP   A 1 29  ? -17.656 -12.179 8.629   0.25 78.17  ? 292  TRP   A C   1 
ATOM   161  O  O   . TRP   A 1 29  ? -17.423 -10.971 8.849   0.25 79.56  ? 292  TRP   A O   1 
ATOM   162  C  CB  . TRP   A 1 29  ? -19.652 -11.388 7.263   0.25 79.47  ? 292  TRP   A CB  1 
ATOM   163  C  CG  . TRP   A 1 29  ? -18.927 -11.020 6.003   0.25 79.78  ? 292  TRP   A CG  1 
ATOM   164  C  CD1 . TRP   A 1 29  ? -18.184 -9.897  5.775   0.25 80.41  ? 292  TRP   A CD1 1 
ATOM   165  C  CD2 . TRP   A 1 29  ? -18.863 -11.793 4.790   0.25 78.78  ? 292  TRP   A CD2 1 
ATOM   166  N  NE1 . TRP   A 1 29  ? -17.672 -9.913  4.505   0.25 79.86  ? 292  TRP   A NE1 1 
ATOM   167  C  CE2 . TRP   A 1 29  ? -18.069 -11.065 3.877   0.25 79.42  ? 292  TRP   A CE2 1 
ATOM   168  C  CE3 . TRP   A 1 29  ? -19.401 -13.021 4.386   0.25 77.84  ? 292  TRP   A CE3 1 
ATOM   169  C  CZ2 . TRP   A 1 29  ? -17.806 -11.527 2.588   0.25 78.63  ? 292  TRP   A CZ2 1 
ATOM   170  C  CZ3 . TRP   A 1 29  ? -19.138 -13.477 3.113   0.25 77.94  ? 292  TRP   A CZ3 1 
ATOM   171  C  CH2 . TRP   A 1 29  ? -18.352 -12.739 2.228   0.25 77.79  ? 292  TRP   A CH2 1 
ATOM   172  N  N   . HIS   A 1 30  ? -16.791 -13.173 8.863   0.25 74.70  ? 293  HIS   A N   1 
ATOM   173  C  CA  . HIS   A 1 30  ? -15.425 -13.009 9.433   0.25 73.18  ? 293  HIS   A CA  1 
ATOM   174  C  C   . HIS   A 1 30  ? -14.377 -13.169 8.324   0.25 72.25  ? 293  HIS   A C   1 
ATOM   175  O  O   . HIS   A 1 30  ? -14.514 -14.110 7.522   0.25 71.40  ? 293  HIS   A O   1 
ATOM   176  C  CB  . HIS   A 1 30  ? -15.206 -13.978 10.608  0.25 71.27  ? 293  HIS   A CB  1 
ATOM   177  C  CG  . HIS   A 1 30  ? -15.044 -15.414 10.229  0.25 69.14  ? 293  HIS   A CG  1 
ATOM   178  N  ND1 . HIS   A 1 30  ? -16.123 -16.249 10.012  0.25 67.65  ? 293  HIS   A ND1 1 
ATOM   179  C  CD2 . HIS   A 1 30  ? -13.940 -16.174 10.059  0.25 68.89  ? 293  HIS   A CD2 1 
ATOM   180  C  CE1 . HIS   A 1 30  ? -15.690 -17.456 9.710   0.25 67.69  ? 293  HIS   A CE1 1 
ATOM   181  N  NE2 . HIS   A 1 30  ? -14.353 -17.437 9.731   0.25 67.23  ? 293  HIS   A NE2 1 
ATOM   182  N  N   . TYR   A 1 31  ? -13.392 -12.265 8.276   0.25 73.65  ? 294  TYR   A N   1 
ATOM   183  C  CA  . TYR   A 1 31  ? -12.228 -12.303 7.350   0.25 73.97  ? 294  TYR   A CA  1 
ATOM   184  C  C   . TYR   A 1 31  ? -11.070 -13.024 8.052   0.25 74.46  ? 294  TYR   A C   1 
ATOM   185  O  O   . TYR   A 1 31  ? -10.293 -12.362 8.771   0.25 75.53  ? 294  TYR   A O   1 
ATOM   186  C  CB  . TYR   A 1 31  ? -11.845 -10.889 6.899   0.25 75.96  ? 294  TYR   A CB  1 
ATOM   187  C  CG  . TYR   A 1 31  ? -10.924 -10.832 5.704   0.25 79.22  ? 294  TYR   A CG  1 
ATOM   188  C  CD1 . TYR   A 1 31  ? -9.566  -11.084 5.827   0.25 80.46  ? 294  TYR   A CD1 1 
ATOM   189  C  CD2 . TYR   A 1 31  ? -11.409 -10.522 4.442   0.25 81.03  ? 294  TYR   A CD2 1 
ATOM   190  C  CE1 . TYR   A 1 31  ? -8.717  -11.034 4.732   0.25 81.26  ? 294  TYR   A CE1 1 
ATOM   191  C  CE2 . TYR   A 1 31  ? -10.574 -10.464 3.337   0.25 81.22  ? 294  TYR   A CE2 1 
ATOM   192  C  CZ  . TYR   A 1 31  ? -9.221  -10.719 3.482   0.25 81.55  ? 294  TYR   A CZ  1 
ATOM   193  O  OH  . TYR   A 1 31  ? -8.390  -10.670 2.399   0.25 79.13  ? 294  TYR   A OH  1 
ATOM   194  N  N   . ASP   A 1 32  ? -10.974 -14.345 7.859   0.25 73.92  ? 295  ASP   A N   1 
ATOM   195  C  CA  . ASP   A 1 32  ? -9.925  -15.225 8.445   0.25 74.31  ? 295  ASP   A CA  1 
ATOM   196  C  C   . ASP   A 1 32  ? -8.569  -14.852 7.830   0.25 75.48  ? 295  ASP   A C   1 
ATOM   197  O  O   . ASP   A 1 32  ? -8.282  -15.312 6.707   0.25 75.21  ? 295  ASP   A O   1 
ATOM   198  C  CB  . ASP   A 1 32  ? -10.272 -16.703 8.235   0.25 72.35  ? 295  ASP   A CB  1 
ATOM   199  C  CG  . ASP   A 1 32  ? -9.392  -17.687 8.993   0.25 72.22  ? 295  ASP   A CG  1 
ATOM   200  O  OD1 . ASP   A 1 32  ? -8.348  -17.264 9.528   0.25 72.33  ? 295  ASP   A OD1 1 
ATOM   201  O  OD2 . ASP   A 1 32  ? -9.762  -18.877 9.043   0.25 70.14  ? 295  ASP   A OD2 1 
ATOM   202  N  N   . GLN   A 1 33  ? -7.768  -14.061 8.555   0.25 75.97  ? 296  GLN   A N   1 
ATOM   203  C  CA  . GLN   A 1 33  ? -6.494  -13.458 8.068   0.25 78.27  ? 296  GLN   A CA  1 
ATOM   204  C  C   . GLN   A 1 33  ? -5.478  -14.551 7.711   0.25 79.30  ? 296  GLN   A C   1 
ATOM   205  O  O   . GLN   A 1 33  ? -4.520  -14.232 6.978   0.25 78.61  ? 296  GLN   A O   1 
ATOM   206  C  CB  . GLN   A 1 33  ? -5.908  -12.505 9.115   0.25 79.48  ? 296  GLN   A CB  1 
ATOM   207  C  CG  . GLN   A 1 33  ? -6.569  -11.133 9.137   0.25 80.10  ? 296  GLN   A CG  1 
ATOM   208  C  CD  . GLN   A 1 33  ? -6.190  -10.270 7.957   0.25 80.58  ? 296  GLN   A CD  1 
ATOM   209  O  OE1 . GLN   A 1 33  ? -5.482  -10.696 7.046   0.25 80.44  ? 296  GLN   A OE1 1 
ATOM   210  N  NE2 . GLN   A 1 33  ? -6.663  -9.034  7.962   0.25 80.92  ? 296  GLN   A NE2 1 
ATOM   211  N  N   . ASP   A 1 34  ? -5.676  -15.779 8.208   0.25 81.48  ? 297  ASP   A N   1 
ATOM   212  C  CA  . ASP   A 1 34  ? -4.810  -16.958 7.935   0.25 84.56  ? 297  ASP   A CA  1 
ATOM   213  C  C   . ASP   A 1 34  ? -5.395  -17.774 6.771   0.25 86.96  ? 297  ASP   A C   1 
ATOM   214  O  O   . ASP   A 1 34  ? -5.326  -19.020 6.837   0.25 85.94  ? 297  ASP   A O   1 
ATOM   215  C  CB  . ASP   A 1 34  ? -4.649  -17.817 9.196   0.25 85.22  ? 297  ASP   A CB  1 
ATOM   216  C  CG  . ASP   A 1 34  ? -4.179  -17.053 10.426  0.25 85.25  ? 297  ASP   A CG  1 
ATOM   217  O  OD1 . ASP   A 1 34  ? -4.352  -17.586 11.541  0.25 84.62  ? 297  ASP   A OD1 1 
ATOM   218  O  OD2 . ASP   A 1 34  ? -3.642  -15.936 10.262  0.25 83.10  ? 297  ASP   A OD2 1 
ATOM   219  N  N   . HIS   A 1 35  ? -5.930  -17.106 5.739   0.25 89.27  ? 298  HIS   A N   1 
ATOM   220  C  CA  . HIS   A 1 35  ? -6.572  -17.745 4.555   0.25 88.45  ? 298  HIS   A CA  1 
ATOM   221  C  C   . HIS   A 1 35  ? -5.495  -18.411 3.702   0.25 88.53  ? 298  HIS   A C   1 
ATOM   222  O  O   . HIS   A 1 35  ? -4.456  -17.807 3.441   0.25 88.59  ? 298  HIS   A O   1 
ATOM   223  C  CB  . HIS   A 1 35  ? -7.425  -16.736 3.763   0.25 86.95  ? 298  HIS   A CB  1 
ATOM   224  C  CG  . HIS   A 1 35  ? -6.656  -15.719 2.984   0.25 85.92  ? 298  HIS   A CG  1 
ATOM   225  N  ND1 . HIS   A 1 35  ? -6.391  -14.455 3.476   0.25 86.94  ? 298  HIS   A ND1 1 
ATOM   226  C  CD2 . HIS   A 1 35  ? -6.126  -15.758 1.741   0.25 84.47  ? 298  HIS   A CD2 1 
ATOM   227  C  CE1 . HIS   A 1 35  ? -5.716  -13.766 2.576   0.25 85.60  ? 298  HIS   A CE1 1 
ATOM   228  N  NE2 . HIS   A 1 35  ? -5.541  -14.544 1.503   0.25 84.98  ? 298  HIS   A NE2 1 
ATOM   229  N  N   . PRO   A 1 36  ? -5.695  -19.672 3.246   0.25 88.28  ? 299  PRO   A N   1 
ATOM   230  C  CA  . PRO   A 1 36  ? -4.652  -20.387 2.508   0.25 88.16  ? 299  PRO   A CA  1 
ATOM   231  C  C   . PRO   A 1 36  ? -4.516  -20.043 1.014   0.25 89.70  ? 299  PRO   A C   1 
ATOM   232  O  O   . PRO   A 1 36  ? -3.654  -20.619 0.374   0.25 91.99  ? 299  PRO   A O   1 
ATOM   233  C  CB  . PRO   A 1 36  ? -5.098  -21.849 2.659   0.25 88.09  ? 299  PRO   A CB  1 
ATOM   234  C  CG  . PRO   A 1 36  ? -6.608  -21.768 2.686   0.25 87.45  ? 299  PRO   A CG  1 
ATOM   235  C  CD  . PRO   A 1 36  ? -6.908  -20.486 3.437   0.25 87.32  ? 299  PRO   A CD  1 
ATOM   236  N  N   . TYR   A 1 37  ? -5.350  -19.135 0.494   1.00 91.41  ? 300  TYR   A N   1 
ATOM   237  C  CA  . TYR   A 1 37  ? -5.397  -18.799 -0.958  1.00 85.79  ? 300  TYR   A CA  1 
ATOM   238  C  C   . TYR   A 1 37  ? -4.245  -17.866 -1.323  1.00 83.44  ? 300  TYR   A C   1 
ATOM   239  O  O   . TYR   A 1 37  ? -4.039  -16.867 -0.607  1.00 88.29  ? 300  TYR   A O   1 
ATOM   240  C  CB  . TYR   A 1 37  ? -6.774  -18.237 -1.335  1.00 81.24  ? 300  TYR   A CB  1 
ATOM   241  C  CG  . TYR   A 1 37  ? -7.890  -19.129 -0.859  1.00 67.25  ? 300  TYR   A CG  1 
ATOM   242  C  CD1 . TYR   A 1 37  ? -8.003  -20.428 -1.323  1.00 72.58  ? 300  TYR   A CD1 1 
ATOM   243  C  CD2 . TYR   A 1 37  ? -8.766  -18.719 0.127   1.00 64.69  ? 300  TYR   A CD2 1 
ATOM   244  C  CE1 . TYR   A 1 37  ? -8.976  -21.290 -0.844  1.00 66.62  ? 300  TYR   A CE1 1 
ATOM   245  C  CE2 . TYR   A 1 37  ? -9.747  -19.566 0.616   1.00 61.45  ? 300  TYR   A CE2 1 
ATOM   246  C  CZ  . TYR   A 1 37  ? -9.862  -20.845 0.117   1.00 58.65  ? 300  TYR   A CZ  1 
ATOM   247  O  OH  . TYR   A 1 37  ? -10.816 -21.686 0.589   1.00 71.79  ? 300  TYR   A OH  1 
ATOM   248  N  N   . LYS   A 1 38  ? -3.546  -18.199 -2.417  1.00 86.02  ? 301  LYS   A N   1 
ATOM   249  C  CA  . LYS   A 1 38  ? -2.507  -17.346 -3.059  1.00 80.20  ? 301  LYS   A CA  1 
ATOM   250  C  C   . LYS   A 1 38  ? -2.937  -16.831 -4.446  1.00 80.75  ? 301  LYS   A C   1 
ATOM   251  O  O   . LYS   A 1 38  ? -2.797  -15.617 -4.704  1.00 74.36  ? 301  LYS   A O   1 
ATOM   252  C  CB  . LYS   A 1 38  ? -1.171  -18.088 -3.188  1.00 82.74  ? 301  LYS   A CB  1 
ATOM   253  C  CG  . LYS   A 1 38  ? 0.022   -17.193 -3.533  1.00 87.41  ? 301  LYS   A CG  1 
ATOM   254  C  CD  . LYS   A 1 38  ? 0.170   -15.955 -2.649  1.00 80.65  ? 301  LYS   A CD  1 
ATOM   255  C  CE  . LYS   A 1 38  ? 0.986   -14.848 -3.288  1.00 91.97  ? 301  LYS   A CE  1 
ATOM   256  N  NZ  . LYS   A 1 38  ? 2.358   -14.765 -2.725  1.00 94.39  ? 301  LYS   A NZ  1 
ATOM   257  N  N   . THR   A 1 39  ? -3.448  -17.724 -5.301  0.25 78.55  ? 302  THR   A N   1 
ATOM   258  C  CA  . THR   A 1 39  ? -3.846  -17.425 -6.705  0.25 77.21  ? 302  THR   A CA  1 
ATOM   259  C  C   . THR   A 1 39  ? -5.315  -16.983 -6.736  0.25 74.93  ? 302  THR   A C   1 
ATOM   260  O  O   . THR   A 1 39  ? -5.632  -16.052 -7.498  0.25 73.77  ? 302  THR   A O   1 
ATOM   261  C  CB  . THR   A 1 39  ? -3.574  -18.625 -7.620  0.25 77.18  ? 302  THR   A CB  1 
ATOM   262  O  OG1 . THR   A 1 39  ? -4.549  -19.631 -7.343  0.25 76.97  ? 302  THR   A OG1 1 
ATOM   263  C  CG2 . THR   A 1 39  ? -2.180  -19.190 -7.445  0.25 78.21  ? 302  THR   A CG2 1 
ATOM   264  N  N   . TRP   A 1 40  ? -6.171  -17.635 -5.943  0.25 74.45  ? 303  TRP   A N   1 
ATOM   265  C  CA  . TRP   A 1 40  ? -7.595  -17.257 -5.735  0.25 74.13  ? 303  TRP   A CA  1 
ATOM   266  C  C   . TRP   A 1 40  ? -7.670  -15.941 -4.952  0.25 74.23  ? 303  TRP   A C   1 
ATOM   267  O  O   . TRP   A 1 40  ? -6.961  -15.827 -3.932  0.25 73.43  ? 303  TRP   A O   1 
ATOM   268  C  CB  . TRP   A 1 40  ? -8.350  -18.372 -5.000  0.25 74.85  ? 303  TRP   A CB  1 
ATOM   269  C  CG  . TRP   A 1 40  ? -8.653  -19.575 -5.837  0.25 75.35  ? 303  TRP   A CG  1 
ATOM   270  C  CD1 . TRP   A 1 40  ? -7.909  -20.713 -5.944  0.25 76.58  ? 303  TRP   A CD1 1 
ATOM   271  C  CD2 . TRP   A 1 40  ? -9.807  -19.770 -6.673  0.25 76.35  ? 303  TRP   A CD2 1 
ATOM   272  N  NE1 . TRP   A 1 40  ? -8.516  -21.599 -6.792  0.25 77.39  ? 303  TRP   A NE1 1 
ATOM   273  C  CE2 . TRP   A 1 40  ? -9.682  -21.050 -7.255  0.25 77.14  ? 303  TRP   A CE2 1 
ATOM   274  C  CE3 . TRP   A 1 40  ? -10.928 -18.993 -6.984  0.25 76.16  ? 303  TRP   A CE3 1 
ATOM   275  C  CZ2 . TRP   A 1 40  ? -10.637 -21.562 -8.133  0.25 76.67  ? 303  TRP   A CZ2 1 
ATOM   276  C  CZ3 . TRP   A 1 40  ? -11.869 -19.499 -7.854  0.25 77.03  ? 303  TRP   A CZ3 1 
ATOM   277  C  CH2 . TRP   A 1 40  ? -11.724 -20.768 -8.417  0.25 76.24  ? 303  TRP   A CH2 1 
ATOM   278  N  N   . ALA   A 1 41  ? -8.505  -15.000 -5.407  0.25 73.80  ? 304  ALA   A N   1 
ATOM   279  C  CA  . ALA   A 1 41  ? -8.797  -13.713 -4.731  0.25 74.11  ? 304  ALA   A CA  1 
ATOM   280  C  C   . ALA   A 1 41  ? -9.879  -13.935 -3.667  0.25 74.86  ? 304  ALA   A C   1 
ATOM   281  O  O   . ALA   A 1 41  ? -11.057 -14.104 -4.043  0.25 73.48  ? 304  ALA   A O   1 
ATOM   282  C  CB  . ALA   A 1 41  ? -9.215  -12.670 -5.741  0.25 73.06  ? 304  ALA   A CB  1 
ATOM   283  N  N   . TYR   A 1 42  ? -9.479  -13.932 -2.391  0.25 76.48  ? 305  TYR   A N   1 
ATOM   284  C  CA  . TYR   A 1 42  ? -10.341 -14.172 -1.202  0.25 76.25  ? 305  TYR   A CA  1 
ATOM   285  C  C   . TYR   A 1 42  ? -11.087 -12.883 -0.837  0.25 76.47  ? 305  TYR   A C   1 
ATOM   286  O  O   . TYR   A 1 42  ? -10.474 -11.798 -0.909  0.25 78.29  ? 305  TYR   A O   1 
ATOM   287  C  CB  . TYR   A 1 42  ? -9.490  -14.674 -0.032  0.25 76.51  ? 305  TYR   A CB  1 
ATOM   288  C  CG  . TYR   A 1 42  ? -10.208 -14.741 1.291   0.25 76.61  ? 305  TYR   A CG  1 
ATOM   289  C  CD1 . TYR   A 1 42  ? -11.104 -15.760 1.566   0.25 75.97  ? 305  TYR   A CD1 1 
ATOM   290  C  CD2 . TYR   A 1 42  ? -9.989  -13.785 2.271   0.25 77.09  ? 305  TYR   A CD2 1 
ATOM   291  C  CE1 . TYR   A 1 42  ? -11.766 -15.829 2.781   0.25 76.59  ? 305  TYR   A CE1 1 
ATOM   292  C  CE2 . TYR   A 1 42  ? -10.643 -13.839 3.491   0.25 76.32  ? 305  TYR   A CE2 1 
ATOM   293  C  CZ  . TYR   A 1 42  ? -11.536 -14.864 3.747   0.25 76.17  ? 305  TYR   A CZ  1 
ATOM   294  O  OH  . TYR   A 1 42  ? -12.188 -14.924 4.944   0.25 75.11  ? 305  TYR   A OH  1 
ATOM   295  N  N   . HIS   A 1 43  ? -12.363 -13.008 -0.451  0.25 75.41  ? 306  HIS   A N   1 
ATOM   296  C  CA  . HIS   A 1 43  ? -13.270 -11.875 -0.114  0.25 75.67  ? 306  HIS   A CA  1 
ATOM   297  C  C   . HIS   A 1 43  ? -13.744 -11.963 1.344   0.25 74.85  ? 306  HIS   A C   1 
ATOM   298  O  O   . HIS   A 1 43  ? -13.755 -10.910 2.010   0.25 79.07  ? 306  HIS   A O   1 
ATOM   299  C  CB  . HIS   A 1 43  ? -14.436 -11.813 -1.110  0.25 75.51  ? 306  HIS   A CB  1 
ATOM   300  C  CG  . HIS   A 1 43  ? -14.019 -11.367 -2.470  0.25 74.04  ? 306  HIS   A CG  1 
ATOM   301  N  ND1 . HIS   A 1 43  ? -13.652 -12.258 -3.459  0.25 73.66  ? 306  HIS   A ND1 1 
ATOM   302  C  CD2 . HIS   A 1 43  ? -13.887 -10.132 -3.000  0.25 73.88  ? 306  HIS   A CD2 1 
ATOM   303  C  CE1 . HIS   A 1 43  ? -13.321 -11.589 -4.545  0.25 72.99  ? 306  HIS   A CE1 1 
ATOM   304  N  NE2 . HIS   A 1 43  ? -13.457 -10.283 -4.290  0.25 72.96  ? 306  HIS   A NE2 1 
ATOM   305  N  N   . GLY   A 1 44  ? -14.120 -13.155 1.820   1.00 73.59  ? 307  GLY   A N   1 
ATOM   306  C  CA  . GLY   A 1 44  ? -14.580 -13.340 3.211   1.00 72.42  ? 307  GLY   A CA  1 
ATOM   307  C  C   . GLY   A 1 44  ? -14.992 -14.766 3.507   1.00 71.95  ? 307  GLY   A C   1 
ATOM   308  O  O   . GLY   A 1 44  ? -14.906 -15.603 2.594   1.00 71.82  ? 307  GLY   A O   1 
ATOM   309  N  N   . SER   A 1 45  ? -15.408 -15.035 4.748   1.00 81.84  ? 308  SER   A N   1 
ATOM   310  C  CA  . SER   A 1 45  ? -15.848 -16.371 5.230   1.00 87.09  ? 308  SER   A CA  1 
ATOM   311  C  C   . SER   A 1 45  ? -17.180 -16.240 5.970   1.00 89.22  ? 308  SER   A C   1 
ATOM   312  O  O   . SER   A 1 45  ? -17.620 -15.101 6.215   1.00 91.78  ? 308  SER   A O   1 
ATOM   313  C  CB  . SER   A 1 45  ? -14.799 -17.025 6.103   1.00 92.75  ? 308  SER   A CB  1 
ATOM   314  O  OG  . SER   A 1 45  ? -13.540 -17.063 5.445   1.00 92.54  ? 308  SER   A OG  1 
ATOM   315  N  N   . TYR   A 1 46  ? -17.810 -17.382 6.275   0.25 91.40  ? 309  TYR   A N   1 
ATOM   316  C  CA  . TYR   A 1 46  ? -19.035 -17.500 7.112   0.25 93.01  ? 309  TYR   A CA  1 
ATOM   317  C  C   . TYR   A 1 46  ? -19.193 -18.952 7.591   0.25 94.91  ? 309  TYR   A C   1 
ATOM   318  O  O   . TYR   A 1 46  ? -18.449 -19.837 7.119   0.25 94.58  ? 309  TYR   A O   1 
ATOM   319  C  CB  . TYR   A 1 46  ? -20.264 -16.968 6.364   0.25 92.86  ? 309  TYR   A CB  1 
ATOM   320  C  CG  . TYR   A 1 46  ? -20.766 -17.811 5.217   0.25 92.70  ? 309  TYR   A CG  1 
ATOM   321  C  CD1 . TYR   A 1 46  ? -21.648 -18.858 5.431   0.25 92.86  ? 309  TYR   A CD1 1 
ATOM   322  C  CD2 . TYR   A 1 46  ? -20.395 -17.538 3.909   0.25 92.11  ? 309  TYR   A CD2 1 
ATOM   323  C  CE1 . TYR   A 1 46  ? -22.128 -19.628 4.383   0.25 93.18  ? 309  TYR   A CE1 1 
ATOM   324  C  CE2 . TYR   A 1 46  ? -20.865 -18.298 2.849   0.25 92.11  ? 309  TYR   A CE2 1 
ATOM   325  C  CZ  . TYR   A 1 46  ? -21.735 -19.348 3.087   0.25 92.01  ? 309  TYR   A CZ  1 
ATOM   326  O  OH  . TYR   A 1 46  ? -22.207 -20.103 2.052   0.25 90.41  ? 309  TYR   A OH  1 
ATOM   327  N  N   . GLU   A 1 47  ? -20.146 -19.179 8.502   0.25 96.55  ? 310  GLU   A N   1 
ATOM   328  C  CA  . GLU   A 1 47  ? -20.291 -20.422 9.310   0.25 99.80  ? 310  GLU   A CA  1 
ATOM   329  C  C   . GLU   A 1 47  ? -21.154 -21.442 8.555   0.25 101.96 ? 310  GLU   A C   1 
ATOM   330  O  O   . GLU   A 1 47  ? -22.261 -21.068 8.119   0.25 104.55 ? 310  GLU   A O   1 
ATOM   331  C  CB  . GLU   A 1 47  ? -20.899 -20.070 10.671  0.25 101.28 ? 310  GLU   A CB  1 
ATOM   332  C  CG  . GLU   A 1 47  ? -21.073 -21.254 11.609  0.25 100.73 ? 310  GLU   A CG  1 
ATOM   333  C  CD  . GLU   A 1 47  ? -21.512 -20.871 13.013  0.25 99.88  ? 310  GLU   A CD  1 
ATOM   334  O  OE1 . GLU   A 1 47  ? -22.590 -21.333 13.441  0.25 98.97  ? 310  GLU   A OE1 1 
ATOM   335  O  OE2 . GLU   A 1 47  ? -20.777 -20.111 13.675  0.25 97.97  ? 310  GLU   A OE2 1 
ATOM   336  N  N   . THR   A 1 48  ? -20.657 -22.677 8.416   0.25 104.18 ? 311  THR   A N   1 
ATOM   337  C  CA  . THR   A 1 48  ? -21.372 -23.844 7.826   0.25 106.31 ? 311  THR   A CA  1 
ATOM   338  C  C   . THR   A 1 48  ? -20.903 -25.131 8.517   0.25 109.17 ? 311  THR   A C   1 
ATOM   339  O  O   . THR   A 1 48  ? -19.897 -25.068 9.251   0.25 111.02 ? 311  THR   A O   1 
ATOM   340  C  CB  . THR   A 1 48  ? -21.146 -23.939 6.311   0.25 107.41 ? 311  THR   A CB  1 
ATOM   341  O  OG1 . THR   A 1 48  ? -19.740 -24.013 6.072   0.25 108.72 ? 311  THR   A OG1 1 
ATOM   342  C  CG2 . THR   A 1 48  ? -21.728 -22.770 5.547   0.25 107.27 ? 311  THR   A CG2 1 
ATOM   343  N  N   . LYS   A 1 49  ? -21.604 -26.246 8.281   0.25 112.06 ? 312  LYS   A N   1 
ATOM   344  C  CA  . LYS   A 1 49  ? -21.262 -27.595 8.814   0.25 115.46 ? 312  LYS   A CA  1 
ATOM   345  C  C   . LYS   A 1 49  ? -21.837 -28.671 7.884   0.25 116.32 ? 312  LYS   A C   1 
ATOM   346  O  O   . LYS   A 1 49  ? -23.047 -28.590 7.598   0.25 117.88 ? 312  LYS   A O   1 
ATOM   347  C  CB  . LYS   A 1 49  ? -21.786 -27.756 10.247  0.25 117.18 ? 312  LYS   A CB  1 
ATOM   348  C  CG  . LYS   A 1 49  ? -20.787 -27.414 11.346  0.25 118.61 ? 312  LYS   A CG  1 
ATOM   349  C  CD  . LYS   A 1 49  ? -21.378 -27.417 12.741  0.25 118.61 ? 312  LYS   A CD  1 
ATOM   350  C  CE  . LYS   A 1 49  ? -22.223 -26.193 13.031  0.25 118.14 ? 312  LYS   A CE  1 
ATOM   351  N  NZ  . LYS   A 1 49  ? -22.650 -26.145 14.449  0.25 117.91 ? 312  LYS   A NZ  1 
ATOM   352  N  N   . SER   A 1 55  ? -19.558 -41.226 0.256   1.00 96.41  ? 318  SER   A N   1 
ATOM   353  C  CA  . SER   A 1 55  ? -18.453 -42.184 -0.049  1.00 84.16  ? 318  SER   A CA  1 
ATOM   354  C  C   . SER   A 1 55  ? -18.936 -43.332 -0.964  1.00 66.55  ? 318  SER   A C   1 
ATOM   355  O  O   . SER   A 1 55  ? -20.143 -43.457 -1.231  1.00 61.37  ? 318  SER   A O   1 
ATOM   356  C  CB  . SER   A 1 55  ? -17.812 -42.715 1.226   1.00 78.84  ? 318  SER   A CB  1 
ATOM   357  O  OG  . SER   A 1 55  ? -18.657 -43.647 1.888   1.00 79.22  ? 318  SER   A OG  1 
ATOM   358  N  N   . SER   A 1 56  ? -18.002 -44.156 -1.432  1.00 59.90  ? 319  SER   A N   1 
ATOM   359  C  CA  . SER   A 1 56  ? -18.255 -45.247 -2.398  1.00 57.09  ? 319  SER   A CA  1 
ATOM   360  C  C   . SER   A 1 56  ? -18.738 -46.492 -1.635  1.00 56.27  ? 319  SER   A C   1 
ATOM   361  O  O   . SER   A 1 56  ? -17.987 -47.039 -0.792  1.00 59.21  ? 319  SER   A O   1 
ATOM   362  C  CB  . SER   A 1 56  ? -17.021 -45.492 -3.240  1.00 67.71  ? 319  SER   A CB  1 
ATOM   363  O  OG  . SER   A 1 56  ? -16.172 -46.466 -2.654  1.00 61.98  ? 319  SER   A OG  1 
ATOM   364  N  N   . MET   A 1 57  ? -19.947 -46.951 -1.948  1.00 44.08  ? 320  MET   A N   1 
ATOM   365  C  CA  . MET   A 1 57  ? -20.604 -48.134 -1.327  1.00 36.49  ? 320  MET   A CA  1 
ATOM   366  C  C   . MET   A 1 57  ? -20.410 -49.361 -2.235  1.00 32.04  ? 320  MET   A C   1 
ATOM   367  O  O   . MET   A 1 57  ? -20.256 -49.172 -3.455  1.00 30.65  ? 320  MET   A O   1 
ATOM   368  C  CB  . MET   A 1 57  ? -22.075 -47.772 -1.203  1.00 41.75  ? 320  MET   A CB  1 
ATOM   369  C  CG  . MET   A 1 57  ? -22.271 -46.323 -0.658  1.00 43.16  ? 320  MET   A CG  1 
ATOM   370  S  SD  . MET   A 1 57  ? -21.646 -46.186 1.051   1.00 48.65  ? 320  MET   A SD  1 
ATOM   371  C  CE  . MET   A 1 57  ? -22.776 -47.313 1.855   1.00 45.75  ? 320  MET   A CE  1 
ATOM   372  N  N   . VAL   A 1 58  ? -20.402 -50.567 -1.690  1.00 26.27  ? 321  VAL   A N   1 
ATOM   373  C  CA  . VAL   A 1 58  ? -20.200 -51.794 -2.497  1.00 28.43  ? 321  VAL   A CA  1 
ATOM   374  C  C   . VAL   A 1 58  ? -21.544 -52.293 -3.016  1.00 27.67  ? 321  VAL   A C   1 
ATOM   375  O  O   . VAL   A 1 58  ? -22.483 -52.280 -2.254  1.00 29.11  ? 321  VAL   A O   1 
ATOM   376  C  CB  . VAL   A 1 58  ? -19.446 -52.858 -1.709  1.00 32.05  ? 321  VAL   A CB  1 
ATOM   377  C  CG1 . VAL   A 1 58  ? -19.380 -54.160 -2.496  1.00 30.13  ? 321  VAL   A CG1 1 
ATOM   378  C  CG2 . VAL   A 1 58  ? -18.068 -52.337 -1.349  1.00 36.53  ? 321  VAL   A CG2 1 
ATOM   379  N  N   . ASN   A 1 59  ? -21.593 -52.654 -4.293  1.00 22.60  ? 322  ASN   A N   1 
ATOM   380  C  CA  . ASN   A 1 59  ? -22.713 -53.389 -4.910  1.00 24.35  ? 322  ASN   A CA  1 
ATOM   381  C  C   . ASN   A 1 59  ? -22.613 -54.882 -4.566  1.00 25.08  ? 322  ASN   A C   1 
ATOM   382  O  O   . ASN   A 1 59  ? -21.815 -55.589 -5.204  1.00 24.71  ? 322  ASN   A O   1 
ATOM   383  C  CB  . ASN   A 1 59  ? -22.729 -53.168 -6.426  1.00 22.28  ? 322  ASN   A CB  1 
ATOM   384  C  CG  . ASN   A 1 59  ? -23.963 -53.762 -7.079  1.00 24.41  ? 322  ASN   A CG  1 
ATOM   385  O  OD1 . ASN   A 1 59  ? -24.390 -54.896 -6.760  1.00 25.11  ? 322  ASN   A OD1 1 
ATOM   386  N  ND2 . ASN   A 1 59  ? -24.476 -53.059 -8.089  1.00 29.67  ? 322  ASN   A ND2 1 
ATOM   387  N  N   . GLY   A 1 60  ? -23.454 -55.351 -3.646  1.00 24.63  ? 323  GLY   A N   1 
ATOM   388  C  CA  . GLY   A 1 60  ? -23.472 -56.730 -3.136  1.00 24.29  ? 323  GLY   A CA  1 
ATOM   389  C  C   . GLY   A 1 60  ? -23.787 -57.794 -4.171  1.00 27.08  ? 323  GLY   A C   1 
ATOM   390  O  O   . GLY   A 1 60  ? -23.223 -58.922 -4.107  1.00 29.03  ? 323  GLY   A O   1 
ATOM   391  N  N   . VAL   A 1 61  ? -24.656 -57.483 -5.118  1.00 24.56  ? 324  VAL   A N   1 
ATOM   392  C  CA  . VAL   A 1 61  ? -25.003 -58.406 -6.206  1.00 24.99  ? 324  VAL   A CA  1 
ATOM   393  C  C   . VAL   A 1 61  ? -23.762 -58.683 -7.045  1.00 22.99  ? 324  VAL   A C   1 
ATOM   394  O  O   . VAL   A 1 61  ? -23.450 -59.876 -7.273  1.00 21.21  ? 324  VAL   A O   1 
ATOM   395  C  CB  . VAL   A 1 61  ? -26.191 -57.835 -7.023  1.00 23.57  ? 324  VAL   A CB  1 
ATOM   396  C  CG1 . VAL   A 1 61  ? -26.396 -58.586 -8.285  1.00 22.87  ? 324  VAL   A CG1 1 
ATOM   397  C  CG2 . VAL   A 1 61  ? -27.461 -57.850 -6.185  1.00 27.11  ? 324  VAL   A CG2 1 
ATOM   398  N  N   . VAL   A 1 62  ? -23.049 -57.658 -7.511  1.00 21.37  ? 325  VAL   A N   1 
ATOM   399  C  CA  . VAL   A 1 62  ? -21.837 -57.878 -8.360  1.00 20.97  ? 325  VAL   A CA  1 
ATOM   400  C  C   . VAL   A 1 62  ? -20.730 -58.526 -7.499  1.00 21.47  ? 325  VAL   A C   1 
ATOM   401  O  O   . VAL   A 1 62  ? -20.141 -59.504 -7.954  1.00 21.96  ? 325  VAL   A O   1 
ATOM   402  C  CB  . VAL   A 1 62  ? -21.349 -56.580 -9.025  1.00 22.79  ? 325  VAL   A CB  1 
ATOM   403  C  CG1 . VAL   A 1 62  ? -20.070 -56.808 -9.810  1.00 22.59  ? 325  VAL   A CG1 1 
ATOM   404  C  CG2 . VAL   A 1 62  ? -22.414 -55.976 -9.929  1.00 24.84  ? 325  VAL   A CG2 1 
ATOM   405  N  N   . ARG   A 1 63  ? -20.555 -58.134 -6.230  1.00 20.60  ? 326  ARG   A N   1 
ATOM   406  C  CA  . ARG   A 1 63  ? -19.443 -58.717 -5.441  1.00 22.88  ? 326  ARG   A CA  1 
ATOM   407  C  C   . ARG   A 1 63  ? -19.730 -60.190 -5.162  1.00 22.94  ? 326  ARG   A C   1 
ATOM   408  O  O   . ARG   A 1 63  ? -18.773 -61.031 -5.303  1.00 23.95  ? 326  ARG   A O   1 
ATOM   409  C  CB  . ARG   A 1 63  ? -19.198 -57.984 -4.142  1.00 23.17  ? 326  ARG   A CB  1 
ATOM   410  C  CG  . ARG   A 1 63  ? -18.142 -58.648 -3.259  1.00 21.34  ? 326  ARG   A CG  1 
ATOM   411  C  CD  . ARG   A 1 63  ? -17.453 -57.676 -2.324  1.00 20.68  ? 326  ARG   A CD  1 
ATOM   412  N  NE  . ARG   A 1 63  ? -18.360 -57.215 -1.287  1.00 23.37  ? 326  ARG   A NE  1 
ATOM   413  C  CZ  . ARG   A 1 63  ? -18.020 -56.417 -0.289  1.00 23.52  ? 326  ARG   A CZ  1 
ATOM   414  N  NH1 . ARG   A 1 63  ? -16.765 -56.049 -0.141  1.00 24.05  ? 326  ARG   A NH1 1 
ATOM   415  N  NH2 . ARG   A 1 63  ? -18.918 -56.022 0.594   1.00 26.14  ? 326  ARG   A NH2 1 
ATOM   416  N  N   . LEU   A 1 64  ? -20.964 -60.565 -4.805  1.00 21.94  ? 327  LEU   A N   1 
ATOM   417  C  CA  . LEU   A 1 64  ? -21.248 -62.027 -4.578  1.00 21.70  ? 327  LEU   A CA  1 
ATOM   418  C  C   . LEU   A 1 64  ? -21.012 -62.850 -5.847  1.00 21.10  ? 327  LEU   A C   1 
ATOM   419  O  O   . LEU   A 1 64  ? -20.740 -64.062 -5.735  1.00 25.32  ? 327  LEU   A O   1 
ATOM   420  C  CB  . LEU   A 1 64  ? -22.691 -62.255 -4.098  1.00 21.95  ? 327  LEU   A CB  1 
ATOM   421  C  CG  . LEU   A 1 64  ? -22.928 -61.900 -2.631  1.00 26.03  ? 327  LEU   A CG  1 
ATOM   422  C  CD1 . LEU   A 1 64  ? -24.405 -62.009 -2.254  1.00 27.35  ? 327  LEU   A CD1 1 
ATOM   423  C  CD2 . LEU   A 1 64  ? -22.084 -62.771 -1.688  1.00 29.03  ? 327  LEU   A CD2 1 
ATOM   424  N  N   . LEU   A 1 65  ? -21.123 -62.269 -7.041  1.00 22.68  ? 328  LEU   A N   1 
ATOM   425  C  CA  . LEU   A 1 65  ? -20.887 -63.040 -8.303  1.00 24.25  ? 328  LEU   A CA  1 
ATOM   426  C  C   . LEU   A 1 65  ? -19.467 -62.885 -8.873  1.00 23.48  ? 328  LEU   A C   1 
ATOM   427  O  O   . LEU   A 1 65  ? -19.222 -63.418 -9.950  1.00 23.60  ? 328  LEU   A O   1 
ATOM   428  C  CB  . LEU   A 1 65  ? -21.979 -62.640 -9.299  1.00 22.74  ? 328  LEU   A CB  1 
ATOM   429  C  CG  . LEU   A 1 65  ? -23.377 -63.052 -8.806  1.00 25.06  ? 328  LEU   A CG  1 
ATOM   430  C  CD1 . LEU   A 1 65  ? -24.510 -62.468 -9.663  1.00 25.52  ? 328  LEU   A CD1 1 
ATOM   431  C  CD2 . LEU   A 1 65  ? -23.465 -64.556 -8.768  1.00 26.37  ? 328  LEU   A CD2 1 
ATOM   432  N  N   . THR   A 1 66  ? -18.565 -62.219 -8.163  1.00 22.59  ? 329  THR   A N   1 
ATOM   433  C  CA  . THR   A 1 66  ? -17.149 -62.075 -8.562  1.00 23.29  ? 329  THR   A CA  1 
ATOM   434  C  C   . THR   A 1 66  ? -16.244 -62.449 -7.361  1.00 21.84  ? 329  THR   A C   1 
ATOM   435  O  O   . THR   A 1 66  ? -15.211 -61.794 -7.091  1.00 20.85  ? 329  THR   A O   1 
ATOM   436  C  CB  . THR   A 1 66  ? -16.910 -60.658 -9.090  1.00 22.65  ? 329  THR   A CB  1 
ATOM   437  O  OG1 . THR   A 1 66  ? -17.311 -59.681 -8.107  1.00 20.62  ? 329  THR   A OG1 1 
ATOM   438  C  CG2 . THR   A 1 66  ? -17.612 -60.427 -10.422 1.00 23.00  ? 329  THR   A CG2 1 
ATOM   439  N  N   . LYS   A 1 67  ? -16.486 -63.584 -6.757  1.00 18.67  ? 330  LYS   A N   1 
ATOM   440  C  CA  . LYS   A 1 67  ? -15.744 -63.984 -5.528  1.00 21.67  ? 330  LYS   A CA  1 
ATOM   441  C  C   . LYS   A 1 67  ? -14.215 -64.026 -5.701  1.00 22.07  ? 330  LYS   A C   1 
ATOM   442  O  O   . LYS   A 1 67  ? -13.497 -63.631 -4.762  1.00 23.21  ? 330  LYS   A O   1 
ATOM   443  C  CB  . LYS   A 1 67  ? -16.299 -65.305 -5.013  1.00 23.97  ? 330  LYS   A CB  1 
ATOM   444  C  CG  . LYS   A 1 67  ? -15.775 -65.770 -3.663  1.00 25.33  ? 330  LYS   A CG  1 
ATOM   445  C  CD  . LYS   A 1 67  ? -16.331 -67.106 -3.240  1.00 25.96  ? 330  LYS   A CD  1 
ATOM   446  C  CE  . LYS   A 1 67  ? -16.176 -67.207 -1.725  1.00 35.40  ? 330  LYS   A CE  1 
ATOM   447  N  NZ  . LYS   A 1 67  ? -16.240 -68.604 -1.258  1.00 35.20  ? 330  LYS   A NZ  1 
ATOM   448  N  N   . PRO   A 1 68  ? -13.634 -64.543 -6.794  1.00 20.77  ? 331  PRO   A N   1 
ATOM   449  C  CA  . PRO   A 1 68  ? -12.179 -64.689 -6.922  1.00 22.39  ? 331  PRO   A CA  1 
ATOM   450  C  C   . PRO   A 1 68  ? -11.478 -63.339 -6.718  1.00 23.79  ? 331  PRO   A C   1 
ATOM   451  O  O   . PRO   A 1 68  ? -10.374 -63.297 -6.245  1.00 22.61  ? 331  PRO   A O   1 
ATOM   452  C  CB  . PRO   A 1 68  ? -11.957 -65.138 -8.379  1.00 23.58  ? 331  PRO   A CB  1 
ATOM   453  C  CG  . PRO   A 1 68  ? -13.223 -65.933 -8.661  1.00 26.88  ? 331  PRO   A CG  1 
ATOM   454  C  CD  . PRO   A 1 68  ? -14.341 -65.175 -7.943  1.00 24.53  ? 331  PRO   A CD  1 
ATOM   455  N  N   . TRP   A 1 69  ? -12.192 -62.252 -7.006  1.00 21.53  ? 332  TRP   A N   1 
ATOM   456  C  CA  . TRP   A 1 69  ? -11.641 -60.870 -6.947  1.00 23.03  ? 332  TRP   A CA  1 
ATOM   457  C  C   . TRP   A 1 69  ? -11.676 -60.335 -5.523  1.00 24.77  ? 332  TRP   A C   1 
ATOM   458  O  O   . TRP   A 1 69  ? -11.115 -59.238 -5.300  1.00 24.16  ? 332  TRP   A O   1 
ATOM   459  C  CB  . TRP   A 1 69  ? -12.310 -59.975 -7.987  1.00 23.16  ? 332  TRP   A CB  1 
ATOM   460  C  CG  . TRP   A 1 69  ? -11.939 -60.380 -9.386  1.00 21.43  ? 332  TRP   A CG  1 
ATOM   461  C  CD1 . TRP   A 1 69  ? -10.847 -59.928 -10.080 1.00 21.89  ? 332  TRP   A CD1 1 
ATOM   462  C  CD2 . TRP   A 1 69  ? -12.521 -61.430 -10.196 1.00 23.19  ? 332  TRP   A CD2 1 
ATOM   463  N  NE1 . TRP   A 1 69  ? -10.737 -60.577 -11.282 1.00 21.94  ? 332  TRP   A NE1 1 
ATOM   464  C  CE2 . TRP   A 1 69  ? -11.741 -61.512 -11.381 1.00 21.92  ? 332  TRP   A CE2 1 
ATOM   465  C  CE3 . TRP   A 1 69  ? -13.632 -62.275 -10.067 1.00 23.63  ? 332  TRP   A CE3 1 
ATOM   466  C  CZ2 . TRP   A 1 69  ? -12.067 -62.368 -12.418 1.00 24.43  ? 332  TRP   A CZ2 1 
ATOM   467  C  CZ3 . TRP   A 1 69  ? -13.955 -63.121 -11.104 1.00 22.19  ? 332  TRP   A CZ3 1 
ATOM   468  C  CH2 . TRP   A 1 69  ? -13.146 -63.206 -12.243 1.00 24.48  ? 332  TRP   A CH2 1 
ATOM   469  N  N   . ASP   A 1 70  ? -12.239 -61.092 -4.578  1.00 23.58  ? 333  ASP   A N   1 
ATOM   470  C  CA  . ASP   A 1 70  ? -12.315 -60.623 -3.166  1.00 21.43  ? 333  ASP   A CA  1 
ATOM   471  C  C   . ASP   A 1 70  ? -10.911 -60.561 -2.519  1.00 22.40  ? 333  ASP   A C   1 
ATOM   472  O  O   . ASP   A 1 70  ? -10.799 -59.923 -1.446  1.00 24.26  ? 333  ASP   A O   1 
ATOM   473  C  CB  . ASP   A 1 70  ? -13.246 -61.502 -2.317  1.00 22.63  ? 333  ASP   A CB  1 
ATOM   474  C  CG  . ASP   A 1 70  ? -14.734 -61.432 -2.643  1.00 21.78  ? 333  ASP   A CG  1 
ATOM   475  O  OD1 . ASP   A 1 70  ? -15.137 -60.504 -3.385  1.00 25.83  ? 333  ASP   A OD1 1 
ATOM   476  O  OD2 . ASP   A 1 70  ? -15.504 -62.258 -2.057  1.00 24.04  ? 333  ASP   A OD2 1 
ATOM   477  N  N   . ILE   A 1 71  ? -9.926  -61.260 -3.071  1.00 22.65  ? 334  ILE   A N   1 
ATOM   478  C  CA  . ILE   A 1 71  ? -8.530  -61.375 -2.582  1.00 25.78  ? 334  ILE   A CA  1 
ATOM   479  C  C   . ILE   A 1 71  ? -7.548  -60.640 -3.523  1.00 31.40  ? 334  ILE   A C   1 
ATOM   480  O  O   . ILE   A 1 71  ? -6.333  -60.810 -3.338  1.00 31.75  ? 334  ILE   A O   1 
ATOM   481  C  CB  . ILE   A 1 71  ? -8.170  -62.854 -2.359  1.00 27.03  ? 334  ILE   A CB  1 
ATOM   482  C  CG1 . ILE   A 1 71  ? -8.172  -63.682 -3.651  1.00 29.30  ? 334  ILE   A CG1 1 
ATOM   483  C  CG2 . ILE   A 1 71  ? -9.060  -63.453 -1.285  1.00 28.57  ? 334  ILE   A CG2 1 
ATOM   484  C  CD1 . ILE   A 1 71  ? -7.490  -65.058 -3.496  1.00 33.47  ? 334  ILE   A CD1 1 
ATOM   485  N  N   . ILE   A 1 72  ? -8.010  -59.796 -4.442  1.00 24.95  ? 335  ILE   A N   1 
ATOM   486  C  CA  . ILE   A 1 72  ? -7.147  -59.036 -5.389  1.00 25.25  ? 335  ILE   A CA  1 
ATOM   487  C  C   . ILE   A 1 72  ? -7.179  -57.593 -4.959  1.00 28.27  ? 335  ILE   A C   1 
ATOM   488  O  O   . ILE   A 1 72  ? -8.175  -56.893 -5.205  1.00 27.92  ? 335  ILE   A O   1 
ATOM   489  C  CB  . ILE   A 1 72  ? -7.644  -59.185 -6.850  1.00 33.03  ? 335  ILE   A CB  1 
ATOM   490  C  CG1 . ILE   A 1 72  ? -7.791  -60.652 -7.264  1.00 35.93  ? 335  ILE   A CG1 1 
ATOM   491  C  CG2 . ILE   A 1 72  ? -6.792  -58.333 -7.812  1.00 28.86  ? 335  ILE   A CG2 1 
ATOM   492  C  CD1 . ILE   A 1 72  ? -6.674  -61.292 -8.027  1.00 40.86  ? 335  ILE   A CD1 1 
ATOM   493  N  N   . PRO   A 1 73  ? -6.083  -57.086 -4.336  1.00 29.82  ? 336  PRO   A N   1 
ATOM   494  C  CA  . PRO   A 1 73  ? -6.058  -55.707 -3.847  1.00 30.97  ? 336  PRO   A CA  1 
ATOM   495  C  C   . PRO   A 1 73  ? -6.352  -54.638 -4.897  1.00 32.12  ? 336  PRO   A C   1 
ATOM   496  O  O   . PRO   A 1 73  ? -7.007  -53.674 -4.534  1.00 30.20  ? 336  PRO   A O   1 
ATOM   497  C  CB  . PRO   A 1 73  ? -4.642  -55.545 -3.240  1.00 35.12  ? 336  PRO   A CB  1 
ATOM   498  C  CG  . PRO   A 1 73  ? -4.279  -57.000 -2.856  1.00 36.43  ? 336  PRO   A CG  1 
ATOM   499  C  CD  . PRO   A 1 73  ? -4.872  -57.850 -3.976  1.00 31.42  ? 336  PRO   A CD  1 
ATOM   500  N  N   . MET   A 1 74  ? -5.961  -54.813 -6.153  1.00 29.49  ? 337  MET   A N   1 
ATOM   501  C  CA  . MET   A 1 74  ? -6.294  -53.770 -7.155  1.00 35.01  ? 337  MET   A CA  1 
ATOM   502  C  C   . MET   A 1 74  ? -7.814  -53.590 -7.252  1.00 35.29  ? 337  MET   A C   1 
ATOM   503  O  O   . MET   A 1 74  ? -8.256  -52.452 -7.433  1.00 33.85  ? 337  MET   A O   1 
ATOM   504  C  CB  . MET   A 1 74  ? -5.675  -54.053 -8.525  1.00 36.89  ? 337  MET   A CB  1 
ATOM   505  C  CG  . MET   A 1 74  ? -4.134  -54.059 -8.489  1.00 45.47  ? 337  MET   A CG  1 
ATOM   506  S  SD  . MET   A 1 74  ? -3.450  -52.355 -8.197  1.00 57.50  ? 337  MET   A SD  1 
ATOM   507  C  CE  . MET   A 1 74  ? -4.535  -51.351 -9.214  1.00 48.99  ? 337  MET   A CE  1 
ATOM   508  N  N   . VAL   A 1 75  ? -8.600  -54.638 -7.033  1.00 25.66  ? 338  VAL   A N   1 
ATOM   509  C  CA  . VAL   A 1 75  ? -10.088 -54.568 -7.047  1.00 26.10  ? 338  VAL   A CA  1 
ATOM   510  C  C   . VAL   A 1 75  ? -10.575 -54.050 -5.706  1.00 26.34  ? 338  VAL   A C   1 
ATOM   511  O  O   . VAL   A 1 75  ? -11.340 -53.116 -5.716  1.00 31.59  ? 338  VAL   A O   1 
ATOM   512  C  CB  . VAL   A 1 75  ? -10.762 -55.939 -7.349  1.00 21.50  ? 338  VAL   A CB  1 
ATOM   513  C  CG1 . VAL   A 1 75  ? -12.257 -55.915 -7.044  1.00 22.13  ? 338  VAL   A CG1 1 
ATOM   514  C  CG2 . VAL   A 1 75  ? -10.520 -56.315 -8.795  1.00 22.93  ? 338  VAL   A CG2 1 
ATOM   515  N  N   . THR   A 1 76  ? -10.180 -54.677 -4.618  1.00 24.83  ? 339  THR   A N   1 
ATOM   516  C  CA  . THR   A 1 76  ? -10.765 -54.410 -3.280  1.00 27.06  ? 339  THR   A CA  1 
ATOM   517  C  C   . THR   A 1 76  ? -10.382 -53.034 -2.758  1.00 28.26  ? 339  THR   A C   1 
ATOM   518  O  O   . THR   A 1 76  ? -11.277 -52.384 -2.146  1.00 27.79  ? 339  THR   A O   1 
ATOM   519  C  CB  . THR   A 1 76  ? -10.344 -55.427 -2.227  1.00 29.49  ? 339  THR   A CB  1 
ATOM   520  O  OG1 . THR   A 1 76  ? -8.927  -55.339 -2.039  1.00 28.38  ? 339  THR   A OG1 1 
ATOM   521  C  CG2 . THR   A 1 76  ? -10.795 -56.817 -2.623  1.00 32.16  ? 339  THR   A CG2 1 
ATOM   522  N  N   . GLN   A 1 77  ? -9.218  -52.513 -3.151  1.00 30.01  ? 340  GLN   A N   1 
ATOM   523  C  CA  . GLN   A 1 77  ? -8.801  -51.152 -2.686  1.00 31.10  ? 340  GLN   A CA  1 
ATOM   524  C  C   . GLN   A 1 77  ? -9.597  -50.061 -3.385  1.00 31.85  ? 340  GLN   A C   1 
ATOM   525  O  O   . GLN   A 1 77  ? -9.623  -48.961 -2.827  1.00 29.67  ? 340  GLN   A O   1 
ATOM   526  C  CB  . GLN   A 1 77  ? -7.303  -50.873 -2.835  1.00 32.42  ? 340  GLN   A CB  1 
ATOM   527  C  CG  . GLN   A 1 77  ? -6.415  -51.961 -2.297  1.00 45.98  ? 340  GLN   A CG  1 
ATOM   528  C  CD  . GLN   A 1 77  ? -5.998  -51.886 -0.851  1.00 63.21  ? 340  GLN   A CD  1 
ATOM   529  O  OE1 . GLN   A 1 77  ? -6.535  -51.104 -0.066  1.00 69.10  ? 340  GLN   A OE1 1 
ATOM   530  N  NE2 . GLN   A 1 77  ? -5.034  -52.738 -0.497  1.00 67.63  ? 340  GLN   A NE2 1 
ATOM   531  N  N   . MET   A 1 78  ? -10.165 -50.310 -4.573  1.00 27.20  ? 341  MET   A N   1 
ATOM   532  C  CA  . MET   A 1 78  ? -10.936 -49.271 -5.298  1.00 31.26  ? 341  MET   A CA  1 
ATOM   533  C  C   . MET   A 1 78  ? -12.159 -48.850 -4.501  1.00 27.37  ? 341  MET   A C   1 
ATOM   534  O  O   . MET   A 1 78  ? -12.610 -47.758 -4.731  1.00 28.49  ? 341  MET   A O   1 
ATOM   535  C  CB  . MET   A 1 78  ? -11.403 -49.702 -6.693  1.00 29.24  ? 341  MET   A CB  1 
ATOM   536  C  CG  . MET   A 1 78  ? -10.286 -49.988 -7.632  1.00 41.28  ? 341  MET   A CG  1 
ATOM   537  S  SD  . MET   A 1 78  ? -10.899 -50.349 -9.369  1.00 42.63  ? 341  MET   A SD  1 
ATOM   538  C  CE  . MET   A 1 78  ? -12.161 -49.091 -9.415  1.00 32.83  ? 341  MET   A CE  1 
ATOM   539  N  N   . ALA   A 1 79  ? -12.734 -49.703 -3.649  1.00 27.58  ? 342  ALA   A N   1 
ATOM   540  C  CA  . ALA   A 1 79  ? -13.956 -49.383 -2.875  1.00 33.06  ? 342  ALA   A CA  1 
ATOM   541  C  C   . ALA   A 1 79  ? -13.624 -48.633 -1.565  1.00 33.57  ? 342  ALA   A C   1 
ATOM   542  O  O   . ALA   A 1 79  ? -14.578 -48.194 -0.933  1.00 32.47  ? 342  ALA   A O   1 
ATOM   543  C  CB  . ALA   A 1 79  ? -14.719 -50.688 -2.592  1.00 32.51  ? 342  ALA   A CB  1 
ATOM   544  N  N   . MET   A 1 80  ? -12.358 -48.500 -1.145  1.00 33.20  ? 343  MET   A N   1 
ATOM   545  C  CA  . MET   A 1 80  ? -11.995 -47.917 0.178   1.00 40.37  ? 343  MET   A CA  1 
ATOM   546  C  C   . MET   A 1 80  ? -11.868 -46.376 0.098   1.00 51.90  ? 343  MET   A C   1 
ATOM   547  O  O   . MET   A 1 80  ? -11.486 -45.869 -0.968  1.00 50.51  ? 343  MET   A O   1 
ATOM   548  C  CB  . MET   A 1 80  ? -10.659 -48.495 0.668   1.00 36.80  ? 343  MET   A CB  1 
ATOM   549  C  CG  . MET   A 1 80  ? -10.668 -50.004 0.869   1.00 41.40  ? 343  MET   A CG  1 
ATOM   550  S  SD  . MET   A 1 80  ? -12.111 -50.651 1.853   1.00 44.88  ? 343  MET   A SD  1 
ATOM   551  C  CE  . MET   A 1 80  ? -11.516 -50.418 3.530   1.00 44.85  ? 343  MET   A CE  1 
ATOM   552  N  N   . THR   A 1 81  ? -12.101 -45.653 1.200   1.00 73.12  ? 344  THR   A N   1 
ATOM   553  C  CA  . THR   A 1 81  ? -11.547 -44.290 1.431   1.00 74.26  ? 344  THR   A CA  1 
ATOM   554  C  C   . THR   A 1 81  ? -12.604 -43.200 1.387   1.00 67.04  ? 344  THR   A C   1 
ATOM   555  O  O   . THR   A 1 81  ? -13.785 -43.555 1.586   1.00 73.44  ? 344  THR   A O   1 
ATOM   556  N  N   . LYS   A 1 93  ? -7.712  -28.328 -3.873  0.25 88.41  ? 356  LYS   A N   1 
ATOM   557  C  CA  . LYS   A 1 93  ? -6.467  -29.075 -4.197  0.25 88.94  ? 356  LYS   A CA  1 
ATOM   558  C  C   . LYS   A 1 93  ? -5.313  -28.086 -4.373  0.25 88.95  ? 356  LYS   A C   1 
ATOM   559  O  O   . LYS   A 1 93  ? -5.558  -26.868 -4.280  0.25 89.37  ? 356  LYS   A O   1 
ATOM   560  C  CB  . LYS   A 1 93  ? -6.649  -29.893 -5.477  0.25 89.28  ? 356  LYS   A CB  1 
ATOM   561  C  CG  . LYS   A 1 93  ? -6.906  -29.068 -6.731  0.25 90.46  ? 356  LYS   A CG  1 
ATOM   562  C  CD  . LYS   A 1 93  ? -7.102  -29.898 -7.981  0.25 90.57  ? 356  LYS   A CD  1 
ATOM   563  C  CE  . LYS   A 1 93  ? -7.416  -29.056 -9.200  0.25 90.34  ? 356  LYS   A CE  1 
ATOM   564  N  NZ  . LYS   A 1 93  ? -7.607  -29.890 -10.411 0.25 91.61  ? 356  LYS   A NZ  1 
ATOM   565  N  N   . GLU   A 1 94  ? -4.106  -28.598 -4.626  0.25 88.16  ? 357  GLU   A N   1 
ATOM   566  C  CA  . GLU   A 1 94  ? -2.917  -27.724 -4.814  0.25 86.58  ? 357  GLU   A CA  1 
ATOM   567  C  C   . GLU   A 1 94  ? -2.668  -27.537 -6.313  0.25 83.59  ? 357  GLU   A C   1 
ATOM   568  O  O   . GLU   A 1 94  ? -1.591  -27.022 -6.667  0.25 78.27  ? 357  GLU   A O   1 
ATOM   569  C  CB  . GLU   A 1 94  ? -1.703  -28.325 -4.105  0.25 88.25  ? 357  GLU   A CB  1 
ATOM   570  C  CG  . GLU   A 1 94  ? -1.809  -28.270 -2.592  0.25 89.91  ? 357  GLU   A CG  1 
ATOM   571  C  CD  . GLU   A 1 94  ? -3.009  -28.997 -2.008  0.25 91.78  ? 357  GLU   A CD  1 
ATOM   572  O  OE1 . GLU   A 1 94  ? -3.549  -28.521 -0.991  0.25 90.61  ? 357  GLU   A OE1 1 
ATOM   573  O  OE2 . GLU   A 1 94  ? -3.398  -30.039 -2.571  0.25 94.09  ? 357  GLU   A OE2 1 
ATOM   574  N  N   . LYS   A 1 95  ? -3.619  -27.955 -7.154  0.25 84.28  ? 358  LYS   A N   1 
ATOM   575  C  CA  . LYS   A 1 95  ? -3.497  -27.738 -8.620  0.25 82.15  ? 358  LYS   A CA  1 
ATOM   576  C  C   . LYS   A 1 95  ? -4.385  -26.553 -9.010  0.25 79.67  ? 358  LYS   A C   1 
ATOM   577  O  O   . LYS   A 1 95  ? -3.995  -25.796 -9.915  0.25 78.09  ? 358  LYS   A O   1 
ATOM   578  C  CB  . LYS   A 1 95  ? -3.910  -29.000 -9.382  0.25 81.99  ? 358  LYS   A CB  1 
ATOM   579  C  CG  . LYS   A 1 95  ? -3.729  -28.943 -10.893 0.25 80.65  ? 358  LYS   A CG  1 
ATOM   580  C  CD  . LYS   A 1 95  ? -2.281  -28.839 -11.318 0.25 79.95  ? 358  LYS   A CD  1 
ATOM   581  C  CE  . LYS   A 1 95  ? -2.097  -28.937 -12.817 0.25 79.38  ? 358  LYS   A CE  1 
ATOM   582  N  NZ  . LYS   A 1 95  ? -0.665  -28.912 -13.197 0.25 78.80  ? 358  LYS   A NZ  1 
ATOM   583  N  N   . VAL   A 1 96  ? -5.536  -26.410 -8.348  0.25 79.37  ? 359  VAL   A N   1 
ATOM   584  C  CA  . VAL   A 1 96  ? -6.465  -25.278 -8.639  0.25 78.92  ? 359  VAL   A CA  1 
ATOM   585  C  C   . VAL   A 1 96  ? -5.827  -23.979 -8.138  0.25 78.03  ? 359  VAL   A C   1 
ATOM   586  O  O   . VAL   A 1 96  ? -5.948  -22.956 -8.835  0.25 77.58  ? 359  VAL   A O   1 
ATOM   587  C  CB  . VAL   A 1 96  ? -7.855  -25.502 -8.012  0.25 79.00  ? 359  VAL   A CB  1 
ATOM   588  C  CG1 . VAL   A 1 96  ? -7.789  -25.569 -6.494  0.25 79.48  ? 359  VAL   A CG1 1 
ATOM   589  C  CG2 . VAL   A 1 96  ? -8.853  -24.447 -8.459  0.25 77.38  ? 359  VAL   A CG2 1 
ATOM   590  N  N   . ASP   A 1 97  ? -5.175  -24.028 -6.973  0.25 77.82  ? 360  ASP   A N   1 
ATOM   591  C  CA  . ASP   A 1 97  ? -4.522  -22.817 -6.410  0.25 77.67  ? 360  ASP   A CA  1 
ATOM   592  C  C   . ASP   A 1 97  ? -3.162  -22.640 -7.091  0.25 79.53  ? 360  ASP   A C   1 
ATOM   593  O  O   . ASP   A 1 97  ? -2.158  -22.482 -6.371  0.25 79.87  ? 360  ASP   A O   1 
ATOM   594  C  CB  . ASP   A 1 97  ? -4.429  -22.883 -4.883  0.25 76.40  ? 360  ASP   A CB  1 
ATOM   595  C  CG  . ASP   A 1 97  ? -4.275  -21.520 -4.227  0.25 75.86  ? 360  ASP   A CG  1 
ATOM   596  O  OD1 . ASP   A 1 97  ? -4.149  -20.525 -4.966  0.25 74.35  ? 360  ASP   A OD1 1 
ATOM   597  O  OD2 . ASP   A 1 97  ? -4.290  -21.465 -2.982  0.25 77.33  ? 360  ASP   A OD2 1 
ATOM   598  N  N   . THR   A 1 98  ? -3.137  -22.673 -8.427  0.25 80.66  ? 361  THR   A N   1 
ATOM   599  C  CA  . THR   A 1 98  ? -1.877  -22.443 -9.181  0.25 82.70  ? 361  THR   A CA  1 
ATOM   600  C  C   . THR   A 1 98  ? -2.103  -21.306 -10.180 0.25 84.37  ? 361  THR   A C   1 
ATOM   601  O  O   . THR   A 1 98  ? -3.272  -20.929 -10.384 0.25 82.81  ? 361  THR   A O   1 
ATOM   602  C  CB  . THR   A 1 98  ? -1.403  -23.717 -9.891  0.25 82.82  ? 361  THR   A CB  1 
ATOM   603  O  OG1 . THR   A 1 98  ? -2.394  -24.086 -10.850 0.25 81.39  ? 361  THR   A OG1 1 
ATOM   604  C  CG2 . THR   A 1 98  ? -1.153  -24.865 -8.936  0.25 82.34  ? 361  THR   A CG2 1 
ATOM   605  N  N   . ARG   A 1 99  ? -1.026  -20.789 -10.775 0.25 88.47  ? 362  ARG   A N   1 
ATOM   606  C  CA  . ARG   A 1 99  ? -1.141  -19.675 -11.755 0.25 92.50  ? 362  ARG   A CA  1 
ATOM   607  C  C   . ARG   A 1 99  ? -0.546  -20.119 -13.096 0.25 94.91  ? 362  ARG   A C   1 
ATOM   608  O  O   . ARG   A 1 99  ? 0.382   -20.955 -13.086 0.25 95.22  ? 362  ARG   A O   1 
ATOM   609  C  CB  . ARG   A 1 99  ? -0.431  -18.428 -11.218 0.25 95.29  ? 362  ARG   A CB  1 
ATOM   610  C  CG  . ARG   A 1 99  ? -1.081  -17.117 -11.639 0.25 98.36  ? 362  ARG   A CG  1 
ATOM   611  C  CD  . ARG   A 1 99  ? -0.138  -15.933 -11.525 0.25 100.15 ? 362  ARG   A CD  1 
ATOM   612  N  NE  . ARG   A 1 99  ? 0.914   -15.974 -12.535 0.25 101.81 ? 362  ARG   A NE  1 
ATOM   613  C  CZ  . ARG   A 1 99  ? 1.821   -15.021 -12.736 0.25 100.92 ? 362  ARG   A CZ  1 
ATOM   614  N  NH1 . ARG   A 1 99  ? 1.822   -13.926 -11.992 0.25 101.50 ? 362  ARG   A NH1 1 
ATOM   615  N  NH2 . ARG   A 1 99  ? 2.728   -15.169 -13.686 0.25 100.33 ? 362  ARG   A NH2 1 
ATOM   616  N  N   . THR   A 1 100 ? -1.072  -19.574 -14.199 1.00 96.81  ? 363  THR   A N   1 
ATOM   617  C  CA  . THR   A 1 100 ? -0.604  -19.850 -15.584 1.00 88.49  ? 363  THR   A CA  1 
ATOM   618  C  C   . THR   A 1 100 ? -0.142  -18.532 -16.200 1.00 80.17  ? 363  THR   A C   1 
ATOM   619  O  O   . THR   A 1 100 ? -0.953  -17.598 -16.214 1.00 93.87  ? 363  THR   A O   1 
ATOM   620  C  CB  . THR   A 1 100 ? -1.730  -20.450 -16.436 1.00 92.95  ? 363  THR   A CB  1 
ATOM   621  O  OG1 . THR   A 1 100 ? -2.411  -21.430 -15.650 1.00 81.30  ? 363  THR   A OG1 1 
ATOM   622  C  CG2 . THR   A 1 100 ? -1.237  -21.050 -17.737 1.00 94.09  ? 363  THR   A CG2 1 
ATOM   623  N  N   . GLN   A 1 101 ? 1.094   -18.460 -16.696 1.00 83.82  ? 364  GLN   A N   1 
ATOM   624  C  CA  . GLN   A 1 101 ? 1.659   -17.225 -17.309 1.00 89.23  ? 364  GLN   A CA  1 
ATOM   625  C  C   . GLN   A 1 101 ? 0.886   -16.874 -18.597 1.00 84.45  ? 364  GLN   A C   1 
ATOM   626  O  O   . GLN   A 1 101 ? 0.315   -17.778 -19.224 1.00 82.67  ? 364  GLN   A O   1 
ATOM   627  C  CB  . GLN   A 1 101 ? 3.165   -17.379 -17.556 1.00 86.98  ? 364  GLN   A CB  1 
ATOM   628  C  CG  . GLN   A 1 101 ? 3.759   -16.200 -18.324 1.00 96.52  ? 364  GLN   A CG  1 
ATOM   629  C  CD  . GLN   A 1 101 ? 5.252   -16.037 -18.168 1.00 104.12 ? 364  GLN   A CD  1 
ATOM   630  O  OE1 . GLN   A 1 101 ? 5.999   -17.012 -18.158 1.00 116.00 ? 364  GLN   A OE1 1 
ATOM   631  N  NE2 . GLN   A 1 101 ? 5.698   -14.791 -18.060 1.00 96.53  ? 364  GLN   A NE2 1 
ATOM   632  N  N   . GLU   A 1 102 ? 0.861   -15.588 -18.959 1.00 84.17  ? 365  GLU   A N   1 
ATOM   633  C  CA  . GLU   A 1 102 ? 0.300   -15.057 -20.229 1.00 78.10  ? 365  GLU   A CA  1 
ATOM   634  C  C   . GLU   A 1 102 ? 1.178   -15.516 -21.397 1.00 70.21  ? 365  GLU   A C   1 
ATOM   635  O  O   . GLU   A 1 102 ? 2.407   -15.393 -21.370 1.00 58.87  ? 365  GLU   A O   1 
ATOM   636  C  CB  . GLU   A 1 102 ? 0.196   -13.527 -20.147 1.00 90.79  ? 365  GLU   A CB  1 
ATOM   637  C  CG  . GLU   A 1 102 ? -0.451  -12.844 -21.354 1.00 99.48  ? 365  GLU   A CG  1 
ATOM   638  C  CD  . GLU   A 1 102 ? -1.964  -12.664 -21.324 1.00 109.16 ? 365  GLU   A CD  1 
ATOM   639  O  OE1 . GLU   A 1 102 ? -2.470  -11.745 -22.012 1.00 121.47 ? 365  GLU   A OE1 1 
ATOM   640  O  OE2 . GLU   A 1 102 ? -2.642  -13.447 -20.633 1.00 117.72 ? 365  GLU   A OE2 1 
ATOM   641  N  N   . PRO   A 1 103 ? 0.577   -16.056 -22.481 1.00 57.91  ? 366  PRO   A N   1 
ATOM   642  C  CA  . PRO   A 1 103 ? 1.348   -16.425 -23.660 1.00 53.84  ? 366  PRO   A CA  1 
ATOM   643  C  C   . PRO   A 1 103 ? 1.978   -15.198 -24.327 1.00 55.31  ? 366  PRO   A C   1 
ATOM   644  O  O   . PRO   A 1 103 ? 1.400   -14.151 -24.226 1.00 53.42  ? 366  PRO   A O   1 
ATOM   645  C  CB  . PRO   A 1 103 ? 0.309   -17.087 -24.582 1.00 55.10  ? 366  PRO   A CB  1 
ATOM   646  C  CG  . PRO   A 1 103 ? -0.799  -17.516 -23.630 1.00 57.59  ? 366  PRO   A CG  1 
ATOM   647  C  CD  . PRO   A 1 103 ? -0.852  -16.386 -22.625 1.00 56.22  ? 366  PRO   A CD  1 
ATOM   648  N  N   . LYS   A 1 104 ? 3.093   -15.410 -25.029 1.00 51.73  ? 367  LYS   A N   1 
ATOM   649  C  CA  . LYS   A 1 104 ? 3.771   -14.437 -25.928 1.00 55.29  ? 367  LYS   A CA  1 
ATOM   650  C  C   . LYS   A 1 104 ? 2.798   -13.972 -27.016 1.00 53.24  ? 367  LYS   A C   1 
ATOM   651  O  O   . LYS   A 1 104 ? 1.817   -14.677 -27.286 1.00 47.58  ? 367  LYS   A O   1 
ATOM   652  C  CB  . LYS   A 1 104 ? 4.986   -15.078 -26.630 1.00 60.59  ? 367  LYS   A CB  1 
ATOM   653  C  CG  . LYS   A 1 104 ? 6.079   -15.693 -25.746 1.00 64.95  ? 367  LYS   A CG  1 
ATOM   654  C  CD  . LYS   A 1 104 ? 6.328   -14.911 -24.490 1.00 70.15  ? 367  LYS   A CD  1 
ATOM   655  C  CE  . LYS   A 1 104 ? 7.575   -15.311 -23.738 1.00 69.20  ? 367  LYS   A CE  1 
ATOM   656  N  NZ  . LYS   A 1 104 ? 7.373   -15.002 -22.304 1.00 68.87  ? 367  LYS   A NZ  1 
ATOM   657  N  N   . GLU   A 1 105 ? 3.154   -12.900 -27.716 1.00 47.52  ? 368  GLU   A N   1 
ATOM   658  C  CA  . GLU   A 1 105 ? 2.324   -12.249 -28.758 1.00 53.02  ? 368  GLU   A CA  1 
ATOM   659  C  C   . GLU   A 1 105 ? 2.174   -13.169 -29.974 1.00 48.76  ? 368  GLU   A C   1 
ATOM   660  O  O   . GLU   A 1 105 ? 1.064   -13.174 -30.556 1.00 49.96  ? 368  GLU   A O   1 
ATOM   661  C  CB  . GLU   A 1 105 ? 2.924   -10.881 -29.135 1.00 64.98  ? 368  GLU   A CB  1 
ATOM   662  C  CG  . GLU   A 1 105 ? 2.933   -9.876  -27.973 1.00 68.49  ? 368  GLU   A CG  1 
ATOM   663  C  CD  . GLU   A 1 105 ? 1.570   -9.492  -27.405 1.00 74.21  ? 368  GLU   A CD  1 
ATOM   664  O  OE1 . GLU   A 1 105 ? 0.715   -9.068  -28.203 1.00 86.56  ? 368  GLU   A OE1 1 
ATOM   665  O  OE2 . GLU   A 1 105 ? 1.353   -9.630  -26.174 1.00 61.09  ? 368  GLU   A OE2 1 
ATOM   666  N  N   . GLY   A 1 106 ? 3.248   -13.859 -30.378 1.00 41.59  ? 369  GLY   A N   1 
ATOM   667  C  CA  . GLY   A 1 106 ? 3.212   -14.847 -31.461 1.00 45.54  ? 369  GLY   A CA  1 
ATOM   668  C  C   . GLY   A 1 106 ? 2.192   -15.944 -31.130 1.00 39.09  ? 369  GLY   A C   1 
ATOM   669  O  O   . GLY   A 1 106 ? 1.367   -16.234 -32.004 1.00 42.55  ? 369  GLY   A O   1 
ATOM   670  N  N   . THR   A 1 107 ? 2.241   -16.497 -29.920 1.00 40.60  ? 370  THR   A N   1 
ATOM   671  C  CA  . THR   A 1 107 ? 1.305   -17.556 -29.456 1.00 44.38  ? 370  THR   A CA  1 
ATOM   672  C  C   . THR   A 1 107 ? -0.146  -17.041 -29.506 1.00 50.48  ? 370  THR   A C   1 
ATOM   673  O  O   . THR   A 1 107 ? -0.965  -17.692 -30.191 1.00 43.57  ? 370  THR   A O   1 
ATOM   674  C  CB  . THR   A 1 107 ? 1.716   -18.080 -28.088 1.00 47.69  ? 370  THR   A CB  1 
ATOM   675  O  OG1 . THR   A 1 107 ? 3.121   -18.324 -28.178 1.00 48.49  ? 370  THR   A OG1 1 
ATOM   676  C  CG2 . THR   A 1 107 ? 0.961   -19.341 -27.717 1.00 45.95  ? 370  THR   A CG2 1 
ATOM   677  N  N   . LYS   A 1 108 ? -0.449  -15.886 -28.889 1.00 49.92  ? 371  LYS   A N   1 
ATOM   678  C  CA  . LYS   A 1 108 ? -1.794  -15.220 -28.921 1.00 43.97  ? 371  LYS   A CA  1 
ATOM   679  C  C   . LYS   A 1 108 ? -2.341  -15.021 -30.351 1.00 43.15  ? 371  LYS   A C   1 
ATOM   680  O  O   . LYS   A 1 108 ? -3.536  -15.275 -30.570 1.00 41.51  ? 371  LYS   A O   1 
ATOM   681  C  CB  . LYS   A 1 108 ? -1.727  -13.889 -28.173 1.00 52.22  ? 371  LYS   A CB  1 
ATOM   682  C  CG  . LYS   A 1 108 ? -1.551  -14.027 -26.671 1.00 56.51  ? 371  LYS   A CG  1 
ATOM   683  C  CD  . LYS   A 1 108 ? -1.942  -12.794 -25.897 1.00 56.06  ? 371  LYS   A CD  1 
ATOM   684  C  CE  . LYS   A 1 108 ? -0.822  -11.782 -25.794 1.00 65.93  ? 371  LYS   A CE  1 
ATOM   685  N  NZ  . LYS   A 1 108 ? -0.950  -10.974 -24.557 1.00 67.78  ? 371  LYS   A NZ  1 
ATOM   686  N  N   . LYS   A 1 109 ? -1.523  -14.596 -31.315 1.00 39.37  ? 372  LYS   A N   1 
ATOM   687  C  CA  . LYS   A 1 109 ? -1.935  -14.470 -32.728 1.00 40.87  ? 372  LYS   A CA  1 
ATOM   688  C  C   . LYS   A 1 109 ? -2.299  -15.851 -33.314 1.00 45.38  ? 372  LYS   A C   1 
ATOM   689  O  O   . LYS   A 1 109 ? -3.268  -15.921 -34.117 1.00 45.19  ? 372  LYS   A O   1 
ATOM   690  C  CB  . LYS   A 1 109 ? -0.809  -13.795 -33.527 1.00 44.91  ? 372  LYS   A CB  1 
ATOM   691  C  CG  . LYS   A 1 109 ? -1.176  -13.336 -34.935 1.00 57.63  ? 372  LYS   A CG  1 
ATOM   692  C  CD  . LYS   A 1 109 ? -2.231  -12.223 -34.992 1.00 70.78  ? 372  LYS   A CD  1 
ATOM   693  C  CE  . LYS   A 1 109 ? -1.807  -10.954 -34.281 1.00 74.50  ? 372  LYS   A CE  1 
ATOM   694  N  NZ  . LYS   A 1 109 ? -2.768  -9.853  -34.523 1.00 78.56  ? 372  LYS   A NZ  1 
ATOM   695  N  N   . LEU   A 1 110 ? -1.459  -16.873 -33.080 1.00 42.27  ? 373  LEU   A N   1 
ATOM   696  C  CA  . LEU   A 1 110 ? -1.665  -18.250 -33.639 1.00 42.40  ? 373  LEU   A CA  1 
ATOM   697  C  C   . LEU   A 1 110 ? -3.021  -18.769 -33.143 1.00 30.29  ? 373  LEU   A C   1 
ATOM   698  O  O   . LEU   A 1 110 ? -3.842  -19.209 -33.975 1.00 37.00  ? 373  LEU   A O   1 
ATOM   699  C  CB  . LEU   A 1 110 ? -0.532  -19.193 -33.222 1.00 39.38  ? 373  LEU   A CB  1 
ATOM   700  C  CG  . LEU   A 1 110 ? 0.804   -18.962 -33.936 1.00 41.52  ? 373  LEU   A CG  1 
ATOM   701  C  CD1 . LEU   A 1 110 ? 1.979   -19.603 -33.175 1.00 38.07  ? 373  LEU   A CD1 1 
ATOM   702  C  CD2 . LEU   A 1 110 ? 0.717   -19.455 -35.373 1.00 43.21  ? 373  LEU   A CD2 1 
ATOM   703  N  N   . MET   A 1 111 ? -3.254  -18.629 -31.861 1.00 28.45  ? 374  MET   A N   1 
ATOM   704  C  CA  . MET   A 1 111 ? -4.514  -19.077 -31.225 1.00 33.18  ? 374  MET   A CA  1 
ATOM   705  C  C   . MET   A 1 111 ? -5.712  -18.303 -31.804 1.00 40.27  ? 374  MET   A C   1 
ATOM   706  O  O   . MET   A 1 111 ? -6.730  -18.965 -32.064 1.00 30.25  ? 374  MET   A O   1 
ATOM   707  C  CB  . MET   A 1 111 ? -4.420  -18.922 -29.704 1.00 34.94  ? 374  MET   A CB  1 
ATOM   708  C  CG  . MET   A 1 111 ? -3.419  -19.922 -29.091 1.00 36.72  ? 374  MET   A CG  1 
ATOM   709  S  SD  . MET   A 1 111 ? -3.495  -20.056 -27.298 1.00 44.80  ? 374  MET   A SD  1 
ATOM   710  C  CE  . MET   A 1 111 ? -3.117  -18.386 -26.787 1.00 42.59  ? 374  MET   A CE  1 
ATOM   711  N  N   . LYS   A 1 112 ? -5.622  -16.967 -32.010 1.00 37.21  ? 375  LYS   A N   1 
ATOM   712  C  CA  . LYS   A 1 112 ? -6.785  -16.154 -32.444 1.00 36.77  ? 375  LYS   A CA  1 
ATOM   713  C  C   . LYS   A 1 112 ? -7.129  -16.515 -33.883 1.00 35.73  ? 375  LYS   A C   1 
ATOM   714  O  O   . LYS   A 1 112 ? -8.313  -16.678 -34.155 1.00 34.91  ? 375  LYS   A O   1 
ATOM   715  C  CB  . LYS   A 1 112 ? -6.523  -14.637 -32.399 1.00 52.73  ? 375  LYS   A CB  1 
ATOM   716  C  CG  . LYS   A 1 112 ? -7.608  -13.773 -31.760 1.00 64.21  ? 375  LYS   A CG  1 
ATOM   717  C  CD  . LYS   A 1 112 ? -7.333  -13.521 -30.260 1.00 76.90  ? 375  LYS   A CD  1 
ATOM   718  C  CE  . LYS   A 1 112 ? -8.546  -13.177 -29.410 1.00 78.85  ? 375  LYS   A CE  1 
ATOM   719  N  NZ  . LYS   A 1 112 ? -8.241  -13.267 -27.957 1.00 76.76  ? 375  LYS   A NZ  1 
ATOM   720  N  N   . ILE   A 1 113 ? -6.127  -16.600 -34.764 1.00 32.96  ? 376  ILE   A N   1 
ATOM   721  C  CA  . ILE   A 1 113 ? -6.315  -17.006 -36.184 1.00 34.44  ? 376  ILE   A CA  1 
ATOM   722  C  C   . ILE   A 1 113 ? -6.922  -18.408 -36.220 1.00 38.52  ? 376  ILE   A C   1 
ATOM   723  O  O   . ILE   A 1 113 ? -7.862  -18.645 -37.055 1.00 36.90  ? 376  ILE   A O   1 
ATOM   724  C  CB  . ILE   A 1 113 ? -4.998  -16.966 -36.976 1.00 34.75  ? 376  ILE   A CB  1 
ATOM   725  C  CG1 . ILE   A 1 113 ? -4.462  -15.542 -37.129 1.00 46.29  ? 376  ILE   A CG1 1 
ATOM   726  C  CG2 . ILE   A 1 113 ? -5.142  -17.593 -38.334 1.00 37.35  ? 376  ILE   A CG2 1 
ATOM   727  C  CD1 . ILE   A 1 113 ? -3.018  -15.524 -37.586 1.00 45.92  ? 376  ILE   A CD1 1 
ATOM   728  N  N   . THR   A 1 114 ? -6.348  -19.349 -35.451 1.00 35.90  ? 377  THR   A N   1 
ATOM   729  C  CA  . THR   A 1 114 ? -6.812  -20.762 -35.501 1.00 30.65  ? 377  THR   A CA  1 
ATOM   730  C  C   . THR   A 1 114 ? -8.234  -20.854 -34.962 1.00 27.58  ? 377  THR   A C   1 
ATOM   731  O  O   . THR   A 1 114 ? -9.067  -21.532 -35.590 1.00 28.49  ? 377  THR   A O   1 
ATOM   732  C  CB  . THR   A 1 114 ? -5.875  -21.686 -34.719 1.00 34.64  ? 377  THR   A CB  1 
ATOM   733  O  OG1 . THR   A 1 114 ? -4.617  -21.460 -35.340 1.00 30.88  ? 377  THR   A OG1 1 
ATOM   734  C  CG2 . THR   A 1 114 ? -6.211  -23.157 -34.864 1.00 32.06  ? 377  THR   A CG2 1 
ATOM   735  N  N   . ALA   A 1 115 ? -8.519  -20.219 -33.835 1.00 32.61  ? 378  ALA   A N   1 
ATOM   736  C  CA  . ALA   A 1 115 ? -9.871  -20.256 -33.239 1.00 35.06  ? 378  ALA   A CA  1 
ATOM   737  C  C   . ALA   A 1 115 ? -10.914 -19.619 -34.181 1.00 36.47  ? 378  ALA   A C   1 
ATOM   738  O  O   . ALA   A 1 115 ? -12.002 -20.231 -34.408 1.00 31.97  ? 378  ALA   A O   1 
ATOM   739  C  CB  . ALA   A 1 115 ? -9.870  -19.630 -31.888 1.00 34.56  ? 378  ALA   A CB  1 
ATOM   740  N  N   . GLU   A 1 116 ? -10.590 -18.489 -34.801 1.00 36.82  ? 379  GLU   A N   1 
ATOM   741  C  CA  . GLU   A 1 116 ? -11.503 -17.821 -35.774 1.00 38.08  ? 379  GLU   A CA  1 
ATOM   742  C  C   . GLU   A 1 116 ? -11.845 -18.810 -36.871 1.00 34.86  ? 379  GLU   A C   1 
ATOM   743  O  O   . GLU   A 1 116 ? -13.033 -19.036 -37.184 1.00 35.96  ? 379  GLU   A O   1 
ATOM   744  C  CB  . GLU   A 1 116 ? -10.828 -16.548 -36.325 1.00 44.54  ? 379  GLU   A CB  1 
ATOM   745  C  CG  . GLU   A 1 116 ? -11.719 -15.722 -37.229 1.00 53.65  ? 379  GLU   A CG  1 
ATOM   746  C  CD  . GLU   A 1 116 ? -11.117 -14.415 -37.741 1.00 59.38  ? 379  GLU   A CD  1 
ATOM   747  O  OE1 . GLU   A 1 116 ? -9.908  -14.154 -37.442 1.00 59.19  ? 379  GLU   A OE1 1 
ATOM   748  O  OE2 . GLU   A 1 116 ? -11.852 -13.662 -38.452 1.00 74.66  ? 379  GLU   A OE2 1 
ATOM   749  N  N   . TRP   A 1 117 ? -10.815 -19.420 -37.455 0.28 34.34  ? 380  TRP   A N   1 
ATOM   750  C  CA  . TRP   A 1 117 ? -10.957 -20.417 -38.542 0.28 34.02  ? 380  TRP   A CA  1 
ATOM   751  C  C   . TRP   A 1 117 ? -11.785 -21.622 -38.064 0.28 34.14  ? 380  TRP   A C   1 
ATOM   752  O  O   . TRP   A 1 117 ? -12.616 -22.125 -38.854 0.28 31.64  ? 380  TRP   A O   1 
ATOM   753  C  CB  . TRP   A 1 117 ? -9.575  -20.846 -39.039 0.28 35.04  ? 380  TRP   A CB  1 
ATOM   754  C  CG  . TRP   A 1 117 ? -9.662  -21.899 -40.092 0.28 34.04  ? 380  TRP   A CG  1 
ATOM   755  C  CD1 . TRP   A 1 117 ? -9.827  -21.704 -41.430 0.28 33.26  ? 380  TRP   A CD1 1 
ATOM   756  C  CD2 . TRP   A 1 117 ? -9.619  -23.321 -39.888 0.28 35.45  ? 380  TRP   A CD2 1 
ATOM   757  N  NE1 . TRP   A 1 117 ? -9.871  -22.906 -42.076 0.28 35.14  ? 380  TRP   A NE1 1 
ATOM   758  C  CE2 . TRP   A 1 117 ? -9.748  -23.917 -41.158 0.28 35.09  ? 380  TRP   A CE2 1 
ATOM   759  C  CE3 . TRP   A 1 117 ? -9.467  -24.144 -38.768 0.28 36.02  ? 380  TRP   A CE3 1 
ATOM   760  C  CZ2 . TRP   A 1 117 ? -9.737  -25.299 -41.336 0.28 36.52  ? 380  TRP   A CZ2 1 
ATOM   761  C  CZ3 . TRP   A 1 117 ? -9.453  -25.510 -38.944 0.28 34.77  ? 380  TRP   A CZ3 1 
ATOM   762  C  CH2 . TRP   A 1 117 ? -9.591  -26.077 -40.209 0.28 35.46  ? 380  TRP   A CH2 1 
ATOM   763  N  N   . LEU   A 1 118 ? -11.561 -22.087 -36.831 1.00 33.50  ? 381  LEU   A N   1 
ATOM   764  C  CA  . LEU   A 1 118 ? -12.180 -23.361 -36.365 1.00 32.07  ? 381  LEU   A CA  1 
ATOM   765  C  C   . LEU   A 1 118 ? -13.679 -23.149 -36.102 1.00 29.71  ? 381  LEU   A C   1 
ATOM   766  O  O   . LEU   A 1 118 ? -14.445 -24.009 -36.478 1.00 30.00  ? 381  LEU   A O   1 
ATOM   767  C  CB  . LEU   A 1 118 ? -11.429 -23.860 -35.134 1.00 31.67  ? 381  LEU   A CB  1 
ATOM   768  C  CG  . LEU   A 1 118 ? -11.825 -25.264 -34.665 1.00 33.58  ? 381  LEU   A CG  1 
ATOM   769  C  CD1 . LEU   A 1 118 ? -11.597 -26.284 -35.762 1.00 33.93  ? 381  LEU   A CD1 1 
ATOM   770  C  CD2 . LEU   A 1 118 ? -11.048 -25.620 -33.402 1.00 34.60  ? 381  LEU   A CD2 1 
ATOM   771  N  N   . TRP   A 1 119 ? -14.087 -22.047 -35.452 1.00 30.87  ? 382  TRP   A N   1 
ATOM   772  C  CA  . TRP   A 1 119 ? -15.543 -21.741 -35.277 1.00 35.48  ? 382  TRP   A CA  1 
ATOM   773  C  C   . TRP   A 1 119 ? -16.275 -21.694 -36.631 1.00 37.07  ? 382  TRP   A C   1 
ATOM   774  O  O   . TRP   A 1 119 ? -17.373 -22.276 -36.757 1.00 36.44  ? 382  TRP   A O   1 
ATOM   775  C  CB  . TRP   A 1 119 ? -15.763 -20.483 -34.454 1.00 34.14  ? 382  TRP   A CB  1 
ATOM   776  C  CG  . TRP   A 1 119 ? -15.534 -20.690 -32.992 1.00 28.69  ? 382  TRP   A CG  1 
ATOM   777  C  CD1 . TRP   A 1 119 ? -14.690 -19.980 -32.217 1.00 30.66  ? 382  TRP   A CD1 1 
ATOM   778  C  CD2 . TRP   A 1 119 ? -16.183 -21.631 -32.117 1.00 30.18  ? 382  TRP   A CD2 1 
ATOM   779  N  NE1 . TRP   A 1 119 ? -14.804 -20.349 -30.916 1.00 29.91  ? 382  TRP   A NE1 1 
ATOM   780  C  CE2 . TRP   A 1 119 ? -15.658 -21.414 -30.833 1.00 26.73  ? 382  TRP   A CE2 1 
ATOM   781  C  CE3 . TRP   A 1 119 ? -17.110 -22.668 -32.296 1.00 30.20  ? 382  TRP   A CE3 1 
ATOM   782  C  CZ2 . TRP   A 1 119 ? -16.024 -22.161 -29.722 1.00 25.52  ? 382  TRP   A CZ2 1 
ATOM   783  C  CZ3 . TRP   A 1 119 ? -17.511 -23.374 -31.182 1.00 29.96  ? 382  TRP   A CZ3 1 
ATOM   784  C  CH2 . TRP   A 1 119 ? -16.977 -23.123 -29.916 1.00 27.52  ? 382  TRP   A CH2 1 
ATOM   785  N  N   . LYS   A 1 120 ? -15.682 -21.028 -37.625 0.28 37.31  ? 383  LYS   A N   1 
ATOM   786  C  CA  . LYS   A 1 120 ? -16.259 -20.922 -38.992 0.28 37.84  ? 383  LYS   A CA  1 
ATOM   787  C  C   . LYS   A 1 120 ? -16.464 -22.327 -39.565 0.28 36.47  ? 383  LYS   A C   1 
ATOM   788  O  O   . LYS   A 1 120 ? -17.550 -22.585 -40.104 0.28 36.02  ? 383  LYS   A O   1 
ATOM   789  C  CB  . LYS   A 1 120 ? -15.367 -20.076 -39.901 0.28 40.54  ? 383  LYS   A CB  1 
ATOM   790  C  CG  . LYS   A 1 120 ? -15.388 -18.583 -39.604 0.28 42.81  ? 383  LYS   A CG  1 
ATOM   791  C  CD  . LYS   A 1 120 ? -14.496 -17.775 -40.519 0.28 44.61  ? 383  LYS   A CD  1 
ATOM   792  C  CE  . LYS   A 1 120 ? -14.241 -16.374 -40.005 0.28 46.00  ? 383  LYS   A CE  1 
ATOM   793  N  NZ  . LYS   A 1 120 ? -13.014 -15.797 -40.605 0.28 46.82  ? 383  LYS   A NZ  1 
ATOM   794  N  N   . GLU   A 1 121 ? -15.467 -23.206 -39.436 0.28 36.08  ? 384  GLU   A N   1 
ATOM   795  C  CA  . GLU   A 1 121 ? -15.516 -24.587 -39.987 0.28 35.60  ? 384  GLU   A CA  1 
ATOM   796  C  C   . GLU   A 1 121 ? -16.607 -25.393 -39.271 0.28 34.38  ? 384  GLU   A C   1 
ATOM   797  O  O   . GLU   A 1 121 ? -17.322 -26.139 -39.961 0.28 34.57  ? 384  GLU   A O   1 
ATOM   798  C  CB  . GLU   A 1 121 ? -14.151 -25.264 -39.858 0.28 36.66  ? 384  GLU   A CB  1 
ATOM   799  C  CG  . GLU   A 1 121 ? -13.147 -24.770 -40.879 0.28 38.78  ? 384  GLU   A CG  1 
ATOM   800  C  CD  . GLU   A 1 121 ? -13.289 -25.409 -42.252 0.28 40.16  ? 384  GLU   A CD  1 
ATOM   801  O  OE1 . GLU   A 1 121 ? -14.087 -26.367 -42.379 0.28 41.08  ? 384  GLU   A OE1 1 
ATOM   802  O  OE2 . GLU   A 1 121 ? -12.597 -24.953 -43.189 0.28 41.36  ? 384  GLU   A OE2 1 
ATOM   803  N  N   . LEU   A 1 122 ? -16.709 -25.260 -37.943 1.00 33.46  ? 385  LEU   A N   1 
ATOM   804  C  CA  . LEU   A 1 122 ? -17.688 -26.015 -37.135 1.00 31.44  ? 385  LEU   A CA  1 
ATOM   805  C  C   . LEU   A 1 122 ? -19.094 -25.475 -37.476 1.00 33.82  ? 385  LEU   A C   1 
ATOM   806  O  O   . LEU   A 1 122 ? -20.062 -26.260 -37.368 1.00 29.68  ? 385  LEU   A O   1 
ATOM   807  C  CB  . LEU   A 1 122 ? -17.359 -25.880 -35.647 1.00 28.48  ? 385  LEU   A CB  1 
ATOM   808  C  CG  . LEU   A 1 122 ? -16.075 -26.589 -35.205 1.00 30.91  ? 385  LEU   A CG  1 
ATOM   809  C  CD1 . LEU   A 1 122 ? -15.740 -26.264 -33.760 1.00 31.30  ? 385  LEU   A CD1 1 
ATOM   810  C  CD2 . LEU   A 1 122 ? -16.220 -28.077 -35.425 1.00 30.68  ? 385  LEU   A CD2 1 
ATOM   811  N  N   . GLY   A 1 123 ? -19.183 -24.175 -37.804 1.00 32.28  ? 386  GLY   A N   1 
ATOM   812  C  CA  . GLY   A 1 123 ? -20.437 -23.461 -38.108 1.00 36.96  ? 386  GLY   A CA  1 
ATOM   813  C  C   . GLY   A 1 123 ? -20.960 -23.579 -39.541 1.00 42.26  ? 386  GLY   A C   1 
ATOM   814  O  O   . GLY   A 1 123 ? -22.089 -23.175 -39.769 1.00 44.15  ? 386  GLY   A O   1 
ATOM   815  N  N   . LYS   A 1 124 ? -20.172 -24.137 -40.468 0.28 41.40  ? 387  LYS   A N   1 
ATOM   816  C  CA  . LYS   A 1 124 ? -20.524 -24.208 -41.914 0.28 42.64  ? 387  LYS   A CA  1 
ATOM   817  C  C   . LYS   A 1 124 ? -21.818 -25.010 -42.118 0.28 42.71  ? 387  LYS   A C   1 
ATOM   818  O  O   . LYS   A 1 124 ? -22.604 -24.624 -43.004 0.28 44.40  ? 387  LYS   A O   1 
ATOM   819  C  CB  . LYS   A 1 124 ? -19.369 -24.800 -42.726 0.28 42.29  ? 387  LYS   A CB  1 
ATOM   820  C  CG  . LYS   A 1 124 ? -18.205 -23.846 -42.956 0.28 44.31  ? 387  LYS   A CG  1 
ATOM   821  C  CD  . LYS   A 1 124 ? -17.167 -24.359 -43.933 0.28 45.56  ? 387  LYS   A CD  1 
ATOM   822  C  CE  . LYS   A 1 124 ? -15.972 -23.435 -44.051 0.28 44.89  ? 387  LYS   A CE  1 
ATOM   823  N  NZ  . LYS   A 1 124 ? -14.918 -24.006 -44.922 0.28 45.81  ? 387  LYS   A NZ  1 
ATOM   824  N  N   . LYS   A 1 125 ? -22.026 -26.084 -41.348 1.00 41.74  ? 388  LYS   A N   1 
ATOM   825  C  CA  . LYS   A 1 125 ? -23.212 -26.956 -41.500 1.00 39.75  ? 388  LYS   A CA  1 
ATOM   826  C  C   . LYS   A 1 125 ? -24.086 -26.997 -40.241 1.00 35.24  ? 388  LYS   A C   1 
ATOM   827  O  O   . LYS   A 1 125 ? -24.887 -27.918 -40.125 1.00 40.18  ? 388  LYS   A O   1 
ATOM   828  C  CB  . LYS   A 1 125 ? -22.729 -28.347 -41.860 1.00 43.88  ? 388  LYS   A CB  1 
ATOM   829  C  CG  . LYS   A 1 125 ? -22.017 -28.437 -43.201 1.00 50.79  ? 388  LYS   A CG  1 
ATOM   830  C  CD  . LYS   A 1 125 ? -21.516 -29.862 -43.481 1.00 63.26  ? 388  LYS   A CD  1 
ATOM   831  C  CE  . LYS   A 1 125 ? -20.428 -30.341 -42.533 1.00 65.24  ? 388  LYS   A CE  1 
ATOM   832  N  NZ  . LYS   A 1 125 ? -20.214 -31.808 -42.643 1.00 71.07  ? 388  LYS   A NZ  1 
ATOM   833  N  N   . LYS   A 1 126 ? -23.938 -26.050 -39.323 1.00 33.45  ? 389  LYS   A N   1 
ATOM   834  C  CA  . LYS   A 1 126 ? -24.726 -26.024 -38.081 1.00 35.14  ? 389  LYS   A CA  1 
ATOM   835  C  C   . LYS   A 1 126 ? -25.201 -24.592 -37.871 1.00 39.89  ? 389  LYS   A C   1 
ATOM   836  O  O   . LYS   A 1 126 ? -24.463 -23.671 -38.275 1.00 41.17  ? 389  LYS   A O   1 
ATOM   837  C  CB  . LYS   A 1 126 ? -23.867 -26.410 -36.878 1.00 34.20  ? 389  LYS   A CB  1 
ATOM   838  C  CG  . LYS   A 1 126 ? -23.261 -27.797 -36.936 1.00 34.93  ? 389  LYS   A CG  1 
ATOM   839  C  CD  . LYS   A 1 126 ? -24.207 -28.827 -36.403 1.00 32.74  ? 389  LYS   A CD  1 
ATOM   840  C  CE  . LYS   A 1 126 ? -23.626 -30.198 -36.596 1.00 33.57  ? 389  LYS   A CE  1 
ATOM   841  N  NZ  . LYS   A 1 126 ? -24.665 -31.209 -36.431 1.00 35.19  ? 389  LYS   A NZ  1 
ATOM   842  N  N   . THR   A 1 127 ? -26.291 -24.421 -37.119 1.00 35.55  ? 390  THR   A N   1 
ATOM   843  C  CA  . THR   A 1 127 ? -26.860 -23.092 -36.761 1.00 35.88  ? 390  THR   A CA  1 
ATOM   844  C  C   . THR   A 1 127 ? -26.982 -22.963 -35.251 1.00 30.88  ? 390  THR   A C   1 
ATOM   845  O  O   . THR   A 1 127 ? -27.776 -23.656 -34.618 1.00 37.77  ? 390  THR   A O   1 
ATOM   846  C  CB  . THR   A 1 127 ? -28.265 -22.893 -37.369 1.00 43.62  ? 390  THR   A CB  1 
ATOM   847  O  OG1 . THR   A 1 127 ? -28.086 -23.010 -38.779 1.00 43.55  ? 390  THR   A OG1 1 
ATOM   848  C  CG2 . THR   A 1 127 ? -28.888 -21.571 -36.967 1.00 41.97  ? 390  THR   A CG2 1 
ATOM   849  N  N   . PRO   A 1 128 ? -26.254 -22.028 -34.639 1.00 31.67  ? 391  PRO   A N   1 
ATOM   850  C  CA  . PRO   A 1 128 ? -26.382 -21.795 -33.212 1.00 33.54  ? 391  PRO   A CA  1 
ATOM   851  C  C   . PRO   A 1 128 ? -27.842 -21.425 -32.902 1.00 37.45  ? 391  PRO   A C   1 
ATOM   852  O  O   . PRO   A 1 128 ? -28.502 -20.797 -33.729 1.00 37.58  ? 391  PRO   A O   1 
ATOM   853  C  CB  . PRO   A 1 128 ? -25.433 -20.616 -32.926 1.00 32.07  ? 391  PRO   A CB  1 
ATOM   854  C  CG  . PRO   A 1 128 ? -24.533 -20.524 -34.116 1.00 32.64  ? 391  PRO   A CG  1 
ATOM   855  C  CD  . PRO   A 1 128 ? -25.261 -21.148 -35.284 1.00 33.61  ? 391  PRO   A CD  1 
ATOM   856  N  N   . ARG   A 1 129 ? -28.309 -21.814 -31.727 1.00 36.29  ? 392  ARG   A N   1 
ATOM   857  C  CA  . ARG   A 1 129 ? -29.713 -21.593 -31.301 1.00 36.04  ? 392  ARG   A CA  1 
ATOM   858  C  C   . ARG   A 1 129 ? -29.814 -21.784 -29.787 1.00 45.82  ? 392  ARG   A C   1 
ATOM   859  O  O   . ARG   A 1 129 ? -28.944 -22.478 -29.193 1.00 35.48  ? 392  ARG   A O   1 
ATOM   860  C  CB  . ARG   A 1 129 ? -30.671 -22.480 -32.106 1.00 37.36  ? 392  ARG   A CB  1 
ATOM   861  C  CG  . ARG   A 1 129 ? -30.426 -23.985 -32.080 1.00 40.00  ? 392  ARG   A CG  1 
ATOM   862  C  CD  . ARG   A 1 129 ? -31.215 -24.663 -31.008 1.00 40.40  ? 392  ARG   A CD  1 
ATOM   863  N  NE  . ARG   A 1 129 ? -30.936 -26.086 -30.831 1.00 36.72  ? 392  ARG   A NE  1 
ATOM   864  C  CZ  . ARG   A 1 129 ? -31.515 -26.800 -29.886 1.00 37.54  ? 392  ARG   A CZ  1 
ATOM   865  N  NH1 . ARG   A 1 129 ? -32.447 -26.245 -29.150 1.00 38.50  ? 392  ARG   A NH1 1 
ATOM   866  N  NH2 . ARG   A 1 129 ? -31.248 -28.076 -29.720 1.00 37.18  ? 392  ARG   A NH2 1 
ATOM   867  N  N   . MET   A 1 130 ? -30.843 -21.186 -29.175 1.00 46.53  ? 393  MET   A N   1 
ATOM   868  C  CA  . MET   A 1 130 ? -31.129 -21.362 -27.741 1.00 43.01  ? 393  MET   A CA  1 
ATOM   869  C  C   . MET   A 1 130 ? -31.766 -22.719 -27.503 1.00 43.77  ? 393  MET   A C   1 
ATOM   870  O  O   . MET   A 1 130 ? -32.539 -23.199 -28.365 1.00 44.03  ? 393  MET   A O   1 
ATOM   871  C  CB  . MET   A 1 130 ? -32.051 -20.261 -27.232 1.00 52.26  ? 393  MET   A CB  1 
ATOM   872  C  CG  . MET   A 1 130 ? -31.456 -18.887 -27.434 1.00 61.61  ? 393  MET   A CG  1 
ATOM   873  S  SD  . MET   A 1 130 ? -32.265 -17.617 -26.421 1.00 70.90  ? 393  MET   A SD  1 
ATOM   874  C  CE  . MET   A 1 130 ? -33.939 -17.739 -27.061 1.00 67.04  ? 393  MET   A CE  1 
ATOM   875  N  N   . CYS   A 1 131 ? -31.400 -23.354 -26.396 1.00 38.78  ? 394  CYS   A N   1 
ATOM   876  C  CA  . CYS   A 1 131 ? -32.090 -24.556 -25.895 1.00 44.66  ? 394  CYS   A CA  1 
ATOM   877  C  C   . CYS   A 1 131 ? -33.255 -24.109 -24.990 1.00 45.14  ? 394  CYS   A C   1 
ATOM   878  O  O   . CYS   A 1 131 ? -33.278 -22.964 -24.553 1.00 45.06  ? 394  CYS   A O   1 
ATOM   879  C  CB  . CYS   A 1 131 ? -31.113 -25.482 -25.205 1.00 44.17  ? 394  CYS   A CB  1 
ATOM   880  S  SG  . CYS   A 1 131 ? -29.914 -26.203 -26.351 1.00 43.90  ? 394  CYS   A SG  1 
ATOM   881  N  N   . THR   A 1 132 ? -34.273 -24.931 -24.840 1.00 48.25  ? 395  THR   A N   1 
ATOM   882  C  CA  . THR   A 1 132 ? -35.582 -24.439 -24.342 1.00 56.34  ? 395  THR   A CA  1 
ATOM   883  C  C   . THR   A 1 132 ? -35.828 -24.966 -22.939 1.00 53.09  ? 395  THR   A C   1 
ATOM   884  O  O   . THR   A 1 132 ? -35.241 -26.002 -22.571 1.00 49.78  ? 395  THR   A O   1 
ATOM   885  C  CB  . THR   A 1 132 ? -36.708 -24.924 -25.259 1.00 55.60  ? 395  THR   A CB  1 
ATOM   886  O  OG1 . THR   A 1 132 ? -36.701 -26.352 -25.225 1.00 58.65  ? 395  THR   A OG1 1 
ATOM   887  C  CG2 . THR   A 1 132 ? -36.548 -24.445 -26.684 1.00 63.91  ? 395  THR   A CG2 1 
ATOM   888  N  N   . ARG   A 1 133 ? -36.696 -24.283 -22.186 0.25 56.87  ? 396  ARG   A N   1 
ATOM   889  C  CA  . ARG   A 1 133 ? -37.202 -24.749 -20.865 0.25 57.92  ? 396  ARG   A CA  1 
ATOM   890  C  C   . ARG   A 1 133 ? -37.784 -26.153 -21.049 0.25 59.20  ? 396  ARG   A C   1 
ATOM   891  O  O   . ARG   A 1 133 ? -37.546 -27.011 -20.176 0.25 60.24  ? 396  ARG   A O   1 
ATOM   892  C  CB  . ARG   A 1 133 ? -38.257 -23.792 -20.298 0.25 59.79  ? 396  ARG   A CB  1 
ATOM   893  C  CG  . ARG   A 1 133 ? -37.871 -22.323 -20.379 0.25 60.88  ? 396  ARG   A CG  1 
ATOM   894  C  CD  . ARG   A 1 133 ? -38.597 -21.435 -19.388 0.25 62.76  ? 396  ARG   A CD  1 
ATOM   895  N  NE  . ARG   A 1 133 ? -37.892 -20.174 -19.187 0.25 64.08  ? 396  ARG   A NE  1 
ATOM   896  C  CZ  . ARG   A 1 133 ? -38.263 -19.216 -18.342 0.25 65.71  ? 396  ARG   A CZ  1 
ATOM   897  N  NH1 . ARG   A 1 133 ? -39.354 -19.354 -17.606 0.25 68.09  ? 396  ARG   A NH1 1 
ATOM   898  N  NH2 . ARG   A 1 133 ? -37.542 -18.112 -18.242 0.25 64.80  ? 396  ARG   A NH2 1 
ATOM   899  N  N   . GLU   A 1 134 ? -38.498 -26.369 -22.160 1.00 59.84  ? 397  GLU   A N   1 
ATOM   900  C  CA  . GLU   A 1 134 ? -39.076 -27.684 -22.520 1.00 65.73  ? 397  GLU   A CA  1 
ATOM   901  C  C   . GLU   A 1 134 ? -37.929 -28.697 -22.594 1.00 62.94  ? 397  GLU   A C   1 
ATOM   902  O  O   . GLU   A 1 134 ? -38.028 -29.738 -21.950 1.00 70.61  ? 397  GLU   A O   1 
ATOM   903  C  CB  . GLU   A 1 134 ? -39.863 -27.548 -23.831 1.00 73.84  ? 397  GLU   A CB  1 
ATOM   904  C  CG  . GLU   A 1 134 ? -41.101 -26.647 -23.759 1.00 83.91  ? 397  GLU   A CG  1 
ATOM   905  C  CD  . GLU   A 1 134 ? -40.964 -25.124 -23.606 1.00 93.99  ? 397  GLU   A CD  1 
ATOM   906  O  OE1 . GLU   A 1 134 ? -39.883 -24.546 -23.923 1.00 74.53  ? 397  GLU   A OE1 1 
ATOM   907  O  OE2 . GLU   A 1 134 ? -41.972 -24.488 -23.176 1.00 96.12  ? 397  GLU   A OE2 1 
ATOM   908  N  N   . GLU   A 1 135 ? -36.842 -28.379 -23.315 1.00 69.56  ? 398  GLU   A N   1 
ATOM   909  C  CA  . GLU   A 1 135 ? -35.687 -29.313 -23.490 1.00 70.12  ? 398  GLU   A CA  1 
ATOM   910  C  C   . GLU   A 1 135 ? -35.014 -29.562 -22.141 1.00 68.50  ? 398  GLU   A C   1 
ATOM   911  O  O   . GLU   A 1 135 ? -34.643 -30.721 -21.878 1.00 59.47  ? 398  GLU   A O   1 
ATOM   912  C  CB  . GLU   A 1 135 ? -34.616 -28.781 -24.445 1.00 67.34  ? 398  GLU   A CB  1 
ATOM   913  C  CG  . GLU   A 1 135 ? -34.941 -29.037 -25.900 1.00 65.14  ? 398  GLU   A CG  1 
ATOM   914  C  CD  . GLU   A 1 135 ? -33.924 -28.444 -26.856 1.00 60.89  ? 398  GLU   A CD  1 
ATOM   915  O  OE1 . GLU   A 1 135 ? -33.700 -27.222 -26.765 1.00 49.02  ? 398  GLU   A OE1 1 
ATOM   916  O  OE2 . GLU   A 1 135 ? -33.352 -29.225 -27.667 1.00 58.17  ? 398  GLU   A OE2 1 
ATOM   917  N  N   . PHE   A 1 136 ? -34.805 -28.492 -21.364 1.00 63.98  ? 399  PHE   A N   1 
ATOM   918  C  CA  . PHE   A 1 136 ? -34.198 -28.559 -20.013 1.00 65.38  ? 399  PHE   A CA  1 
ATOM   919  C  C   . PHE   A 1 136 ? -35.041 -29.474 -19.109 1.00 67.48  ? 399  PHE   A C   1 
ATOM   920  O  O   . PHE   A 1 136 ? -34.481 -30.423 -18.476 1.00 54.88  ? 399  PHE   A O   1 
ATOM   921  C  CB  . PHE   A 1 136 ? -34.043 -27.164 -19.409 1.00 64.18  ? 399  PHE   A CB  1 
ATOM   922  C  CG  . PHE   A 1 136 ? -33.196 -27.181 -18.160 1.00 66.85  ? 399  PHE   A CG  1 
ATOM   923  C  CD1 . PHE   A 1 136 ? -31.845 -27.475 -18.238 1.00 55.26  ? 399  PHE   A CD1 1 
ATOM   924  C  CD2 . PHE   A 1 136 ? -33.752 -26.920 -16.918 1.00 63.73  ? 399  PHE   A CD2 1 
ATOM   925  C  CE1 . PHE   A 1 136 ? -31.055 -27.467 -17.108 1.00 53.95  ? 399  PHE   A CE1 1 
ATOM   926  C  CE2 . PHE   A 1 136 ? -32.962 -26.933 -15.784 1.00 62.46  ? 399  PHE   A CE2 1 
ATOM   927  C  CZ  . PHE   A 1 136 ? -31.617 -27.209 -15.884 1.00 60.55  ? 399  PHE   A CZ  1 
ATOM   928  N  N   . THR   A 1 137 ? -36.357 -29.233 -19.068 0.25 66.55  ? 400  THR   A N   1 
ATOM   929  C  CA  . THR   A 1 137 ? -37.338 -29.993 -18.243 0.25 69.65  ? 400  THR   A CA  1 
ATOM   930  C  C   . THR   A 1 137 ? -37.327 -31.479 -18.633 0.25 72.02  ? 400  THR   A C   1 
ATOM   931  O  O   . THR   A 1 137 ? -37.563 -32.314 -17.743 0.25 71.33  ? 400  THR   A O   1 
ATOM   932  C  CB  . THR   A 1 137 ? -38.749 -29.400 -18.361 0.25 68.82  ? 400  THR   A CB  1 
ATOM   933  O  OG1 . THR   A 1 137 ? -38.678 -28.013 -18.028 0.25 68.46  ? 400  THR   A OG1 1 
ATOM   934  C  CG2 . THR   A 1 137 ? -39.758 -30.085 -17.465 0.25 68.79  ? 400  THR   A CG2 1 
ATOM   935  N  N   . ARG   A 1 138 ? -37.075 -31.799 -19.905 0.25 76.02  ? 401  ARG   A N   1 
ATOM   936  C  CA  . ARG   A 1 138 ? -37.068 -33.198 -20.414 0.25 79.70  ? 401  ARG   A CA  1 
ATOM   937  C  C   . ARG   A 1 138 ? -35.741 -33.882 -20.052 0.25 81.83  ? 401  ARG   A C   1 
ATOM   938  O  O   . ARG   A 1 138 ? -35.705 -35.126 -20.076 0.25 82.48  ? 401  ARG   A O   1 
ATOM   939  C  CB  . ARG   A 1 138 ? -37.324 -33.224 -21.925 0.25 82.74  ? 401  ARG   A CB  1 
ATOM   940  C  CG  . ARG   A 1 138 ? -37.729 -34.592 -22.459 0.25 84.39  ? 401  ARG   A CG  1 
ATOM   941  C  CD  . ARG   A 1 138 ? -38.616 -34.511 -23.688 0.25 84.99  ? 401  ARG   A CD  1 
ATOM   942  N  NE  . ARG   A 1 138 ? -37.911 -33.983 -24.851 0.25 86.42  ? 401  ARG   A NE  1 
ATOM   943  C  CZ  . ARG   A 1 138 ? -37.243 -34.707 -25.753 0.25 86.42  ? 401  ARG   A CZ  1 
ATOM   944  N  NH1 . ARG   A 1 138 ? -37.168 -36.025 -25.651 0.25 85.48  ? 401  ARG   A NH1 1 
ATOM   945  N  NH2 . ARG   A 1 138 ? -36.647 -34.099 -26.765 0.25 86.49  ? 401  ARG   A NH2 1 
ATOM   946  N  N   . LYS   A 1 139 ? -34.697 -33.107 -19.731 0.25 84.51  ? 402  LYS   A N   1 
ATOM   947  C  CA  . LYS   A 1 139 ? -33.361 -33.627 -19.326 0.25 87.02  ? 402  LYS   A CA  1 
ATOM   948  C  C   . LYS   A 1 139 ? -33.369 -33.976 -17.831 0.25 89.83  ? 402  LYS   A C   1 
ATOM   949  O  O   . LYS   A 1 139 ? -32.773 -35.013 -17.473 0.25 90.54  ? 402  LYS   A O   1 
ATOM   950  C  CB  . LYS   A 1 139 ? -32.252 -32.616 -19.638 0.25 88.00  ? 402  LYS   A CB  1 
ATOM   951  C  CG  . LYS   A 1 139 ? -31.881 -32.498 -21.110 0.25 90.05  ? 402  LYS   A CG  1 
ATOM   952  C  CD  . LYS   A 1 139 ? -30.688 -31.597 -21.369 0.25 90.42  ? 402  LYS   A CD  1 
ATOM   953  C  CE  . LYS   A 1 139 ? -29.357 -32.268 -21.099 0.25 90.52  ? 402  LYS   A CE  1 
ATOM   954  N  NZ  . LYS   A 1 139 ? -29.036 -33.290 -22.124 0.25 89.34  ? 402  LYS   A NZ  1 
ATOM   955  N  N   . VAL   A 1 140 ? -34.007 -33.147 -16.996 0.25 92.53  ? 403  VAL   A N   1 
ATOM   956  C  CA  . VAL   A 1 140 ? -34.059 -33.334 -15.512 0.25 94.93  ? 403  VAL   A CA  1 
ATOM   957  C  C   . VAL   A 1 140 ? -34.922 -34.564 -15.191 0.25 97.48  ? 403  VAL   A C   1 
ATOM   958  O  O   . VAL   A 1 140 ? -34.622 -35.240 -14.185 0.25 96.87  ? 403  VAL   A O   1 
ATOM   959  C  CB  . VAL   A 1 140 ? -34.564 -32.079 -14.767 0.25 95.01  ? 403  VAL   A CB  1 
ATOM   960  C  CG1 . VAL   A 1 140 ? -33.686 -30.865 -15.033 0.25 94.11  ? 403  VAL   A CG1 1 
ATOM   961  C  CG2 . VAL   A 1 140 ? -36.019 -31.759 -15.069 0.25 95.69  ? 403  VAL   A CG2 1 
ATOM   962  N  N   . ARG   A 1 141 ? -35.938 -34.845 -16.016 0.25 100.13 ? 404  ARG   A N   1 
ATOM   963  C  CA  . ARG   A 1 141 ? -36.883 -35.982 -15.833 0.25 101.63 ? 404  ARG   A CA  1 
ATOM   964  C  C   . ARG   A 1 141 ? -36.292 -37.270 -16.429 0.25 103.80 ? 404  ARG   A C   1 
ATOM   965  O  O   . ARG   A 1 141 ? -36.961 -38.316 -16.324 0.25 106.21 ? 404  ARG   A O   1 
ATOM   966  C  CB  . ARG   A 1 141 ? -38.251 -35.645 -16.440 0.25 100.97 ? 404  ARG   A CB  1 
ATOM   967  C  CG  . ARG   A 1 141 ? -39.023 -34.584 -15.666 0.25 102.12 ? 404  ARG   A CG  1 
ATOM   968  C  CD  . ARG   A 1 141 ? -40.526 -34.806 -15.662 0.25 103.52 ? 404  ARG   A CD  1 
ATOM   969  N  NE  . ARG   A 1 141 ? -41.187 -34.294 -16.857 0.25 104.92 ? 404  ARG   A NE  1 
ATOM   970  C  CZ  . ARG   A 1 141 ? -41.737 -33.084 -16.982 0.25 105.71 ? 404  ARG   A CZ  1 
ATOM   971  N  NH1 . ARG   A 1 141 ? -41.715 -32.218 -15.981 0.25 105.19 ? 404  ARG   A NH1 1 
ATOM   972  N  NH2 . ARG   A 1 141 ? -42.312 -32.743 -18.124 0.25 105.81 ? 404  ARG   A NH2 1 
ATOM   973  N  N   . SER   A 1 142 ? -35.090 -37.203 -17.016 0.25 107.49 ? 405  SER   A N   1 
ATOM   974  C  CA  . SER   A 1 142 ? -34.332 -38.363 -17.561 0.25 110.37 ? 405  SER   A CA  1 
ATOM   975  C  C   . SER   A 1 142 ? -33.088 -38.648 -16.706 0.25 111.02 ? 405  SER   A C   1 
ATOM   976  O  O   . SER   A 1 142 ? -32.279 -39.506 -17.117 0.25 110.30 ? 405  SER   A O   1 
ATOM   977  C  CB  . SER   A 1 142 ? -33.965 -38.130 -19.006 0.25 112.07 ? 405  SER   A CB  1 
ATOM   978  O  OG  . SER   A 1 142 ? -33.050 -37.052 -19.133 0.25 111.87 ? 405  SER   A OG  1 
ATOM   979  N  N   . ASN   A 1 143 ? -32.944 -37.956 -15.567 0.25 112.60 ? 406  ASN   A N   1 
ATOM   980  C  CA  . ASN   A 1 143 ? -31.851 -38.148 -14.573 0.25 114.84 ? 406  ASN   A CA  1 
ATOM   981  C  C   . ASN   A 1 143 ? -30.490 -37.893 -15.235 0.25 114.19 ? 406  ASN   A C   1 
ATOM   982  O  O   . ASN   A 1 143 ? -29.563 -38.700 -15.013 0.25 113.96 ? 406  ASN   A O   1 
ATOM   983  C  CB  . ASN   A 1 143 ? -31.908 -39.540 -13.932 0.25 115.93 ? 406  ASN   A CB  1 
ATOM   984  C  CG  . ASN   A 1 143 ? -33.248 -39.856 -13.300 0.25 117.22 ? 406  ASN   A CG  1 
ATOM   985  O  OD1 . ASN   A 1 143 ? -34.193 -39.074 -13.399 0.25 117.05 ? 406  ASN   A OD1 1 
ATOM   986  N  ND2 . ASN   A 1 143 ? -33.343 -41.004 -12.649 0.25 117.64 ? 406  ASN   A ND2 1 
ATOM   987  N  N   . ALA   A 1 144 ? -30.376 -36.809 -16.012 0.25 114.73 ? 407  ALA   A N   1 
ATOM   988  C  CA  . ALA   A 1 144 ? -29.119 -36.344 -16.645 0.25 115.68 ? 407  ALA   A CA  1 
ATOM   989  C  C   . ALA   A 1 144 ? -28.305 -35.548 -15.616 0.25 118.15 ? 407  ALA   A C   1 
ATOM   990  O  O   . ALA   A 1 144 ? -28.903 -34.706 -14.917 0.25 118.30 ? 407  ALA   A O   1 
ATOM   991  C  CB  . ALA   A 1 144 ? -29.425 -35.518 -17.872 0.25 114.20 ? 407  ALA   A CB  1 
ATOM   992  N  N   . ALA   A 1 145 ? -26.998 -35.816 -15.526 0.25 119.18 ? 408  ALA   A N   1 
ATOM   993  C  CA  . ALA   A 1 145 ? -26.062 -35.188 -14.562 0.25 118.41 ? 408  ALA   A CA  1 
ATOM   994  C  C   . ALA   A 1 145 ? -25.792 -33.735 -14.976 0.25 119.40 ? 408  ALA   A C   1 
ATOM   995  O  O   . ALA   A 1 145 ? -24.991 -33.524 -15.910 0.25 119.65 ? 408  ALA   A O   1 
ATOM   996  C  CB  . ALA   A 1 145 ? -24.785 -35.990 -14.480 0.25 117.56 ? 408  ALA   A CB  1 
ATOM   997  N  N   . LEU   A 1 146 ? -26.443 -32.778 -14.303 0.25 119.96 ? 409  LEU   A N   1 
ATOM   998  C  CA  . LEU   A 1 146 ? -26.332 -31.318 -14.576 0.25 120.17 ? 409  LEU   A CA  1 
ATOM   999  C  C   . LEU   A 1 146 ? -25.332 -30.666 -13.610 0.25 119.25 ? 409  LEU   A C   1 
ATOM   1000 O  O   . LEU   A 1 146 ? -24.748 -29.631 -13.992 0.25 119.23 ? 409  LEU   A O   1 
ATOM   1001 C  CB  . LEU   A 1 146 ? -27.717 -30.674 -14.444 0.25 120.73 ? 409  LEU   A CB  1 
ATOM   1002 C  CG  . LEU   A 1 146 ? -28.779 -31.175 -15.423 0.25 121.54 ? 409  LEU   A CG  1 
ATOM   1003 C  CD1 . LEU   A 1 146 ? -30.134 -30.562 -15.107 0.25 121.93 ? 409  LEU   A CD1 1 
ATOM   1004 C  CD2 . LEU   A 1 146 ? -28.388 -30.881 -16.864 0.25 120.60 ? 409  LEU   A CD2 1 
ATOM   1005 N  N   . GLY   A 1 147 ? -25.145 -31.235 -12.412 1.00 118.69 ? 410  GLY   A N   1 
ATOM   1006 C  CA  . GLY   A 1 147 ? -24.264 -30.651 -11.382 1.00 112.52 ? 410  GLY   A CA  1 
ATOM   1007 C  C   . GLY   A 1 147 ? -24.951 -29.484 -10.684 1.00 111.84 ? 410  GLY   A C   1 
ATOM   1008 O  O   . GLY   A 1 147 ? -24.403 -28.365 -10.693 1.00 102.89 ? 410  GLY   A O   1 
ATOM   1009 N  N   . ALA   A 1 148 ? -26.138 -29.735 -10.121 0.25 109.76 ? 411  ALA   A N   1 
ATOM   1010 C  CA  . ALA   A 1 148 ? -26.993 -28.733 -9.441  0.25 109.66 ? 411  ALA   A CA  1 
ATOM   1011 C  C   . ALA   A 1 148 ? -26.911 -28.929 -7.921  0.25 110.31 ? 411  ALA   A C   1 
ATOM   1012 O  O   . ALA   A 1 148 ? -26.763 -30.087 -7.483  0.25 109.48 ? 411  ALA   A O   1 
ATOM   1013 C  CB  . ALA   A 1 148 ? -28.412 -28.847 -9.939  0.25 108.41 ? 411  ALA   A CB  1 
ATOM   1014 N  N   . ILE   A 1 149 ? -27.006 -27.834 -7.157  0.25 110.43 ? 412  ILE   A N   1 
ATOM   1015 C  CA  . ILE   A 1 149 ? -26.958 -27.832 -5.662  0.25 110.39 ? 412  ILE   A CA  1 
ATOM   1016 C  C   . ILE   A 1 149 ? -28.357 -28.152 -5.120  0.25 110.52 ? 412  ILE   A C   1 
ATOM   1017 O  O   . ILE   A 1 149 ? -29.336 -27.774 -5.796  0.25 110.73 ? 412  ILE   A O   1 
ATOM   1018 C  CB  . ILE   A 1 149 ? -26.412 -26.495 -5.113  0.25 110.09 ? 412  ILE   A CB  1 
ATOM   1019 C  CG1 . ILE   A 1 149 ? -27.381 -25.326 -5.328  0.25 110.30 ? 412  ILE   A CG1 1 
ATOM   1020 C  CG2 . ILE   A 1 149 ? -25.037 -26.202 -5.696  0.25 109.75 ? 412  ILE   A CG2 1 
ATOM   1021 C  CD1 . ILE   A 1 149 ? -26.958 -24.039 -4.657  0.25 109.97 ? 412  ILE   A CD1 1 
ATOM   1022 N  N   . LYS   A 1 155 ? -35.760 -24.542 -0.597  0.25 60.61  ? 418  LYS   A N   1 
ATOM   1023 C  CA  . LYS   A 1 155 ? -37.169 -24.399 -1.055  0.25 60.24  ? 418  LYS   A CA  1 
ATOM   1024 C  C   . LYS   A 1 155 ? -37.589 -25.682 -1.790  0.25 58.21  ? 418  LYS   A C   1 
ATOM   1025 O  O   . LYS   A 1 155 ? -38.649 -26.235 -1.438  0.25 59.94  ? 418  LYS   A O   1 
ATOM   1026 C  CB  . LYS   A 1 155 ? -37.321 -23.148 -1.931  0.25 60.64  ? 418  LYS   A CB  1 
ATOM   1027 C  CG  . LYS   A 1 155 ? -38.661 -22.428 -1.823  0.25 61.54  ? 418  LYS   A CG  1 
ATOM   1028 C  CD  . LYS   A 1 155 ? -39.821 -23.189 -2.434  0.25 62.43  ? 418  LYS   A CD  1 
ATOM   1029 C  CE  . LYS   A 1 155 ? -41.143 -22.459 -2.333  0.25 62.40  ? 418  LYS   A CE  1 
ATOM   1030 N  NZ  . LYS   A 1 155 ? -42.215 -23.173 -3.066  0.25 62.39  ? 418  LYS   A NZ  1 
ATOM   1031 N  N   . TRP   A 1 156 ? -36.783 -26.138 -2.757  0.25 55.91  ? 419  TRP   A N   1 
ATOM   1032 C  CA  . TRP   A 1 156 ? -37.028 -27.365 -3.568  0.25 54.63  ? 419  TRP   A CA  1 
ATOM   1033 C  C   . TRP   A 1 156 ? -36.040 -28.466 -3.171  0.25 55.67  ? 419  TRP   A C   1 
ATOM   1034 O  O   . TRP   A 1 156 ? -34.830 -28.178 -3.100  0.25 54.73  ? 419  TRP   A O   1 
ATOM   1035 C  CB  . TRP   A 1 156 ? -36.934 -27.054 -5.068  0.25 52.82  ? 419  TRP   A CB  1 
ATOM   1036 C  CG  . TRP   A 1 156 ? -37.922 -26.021 -5.508  0.25 49.92  ? 419  TRP   A CG  1 
ATOM   1037 C  CD1 . TRP   A 1 156 ? -39.265 -26.191 -5.666  0.25 48.94  ? 419  TRP   A CD1 1 
ATOM   1038 C  CD2 . TRP   A 1 156 ? -37.650 -24.640 -5.803  0.25 48.23  ? 419  TRP   A CD2 1 
ATOM   1039 N  NE1 . TRP   A 1 156 ? -39.846 -25.015 -6.052  0.25 49.07  ? 419  TRP   A NE1 1 
ATOM   1040 C  CE2 . TRP   A 1 156 ? -38.882 -24.046 -6.148  0.25 47.90  ? 419  TRP   A CE2 1 
ATOM   1041 C  CE3 . TRP   A 1 156 ? -36.492 -23.854 -5.820  0.25 48.03  ? 419  TRP   A CE3 1 
ATOM   1042 C  CZ2 . TRP   A 1 156 ? -38.983 -22.702 -6.502  0.25 47.75  ? 419  TRP   A CZ2 1 
ATOM   1043 C  CZ3 . TRP   A 1 156 ? -36.592 -22.526 -6.171  0.25 47.69  ? 419  TRP   A CZ3 1 
ATOM   1044 C  CH2 . TRP   A 1 156 ? -37.823 -21.960 -6.504  0.25 48.23  ? 419  TRP   A CH2 1 
ATOM   1045 N  N   . LYS   A 1 157 ? -36.547 -29.681 -2.940  0.25 59.28  ? 420  LYS   A N   1 
ATOM   1046 C  CA  . LYS   A 1 157 ? -35.741 -30.879 -2.579  0.25 60.60  ? 420  LYS   A CA  1 
ATOM   1047 C  C   . LYS   A 1 157 ? -34.878 -31.269 -3.785  0.25 60.95  ? 420  LYS   A C   1 
ATOM   1048 O  O   . LYS   A 1 157 ? -33.641 -31.132 -3.690  0.25 63.12  ? 420  LYS   A O   1 
ATOM   1049 C  CB  . LYS   A 1 157 ? -36.666 -32.018 -2.140  0.25 62.17  ? 420  LYS   A CB  1 
ATOM   1050 C  CG  . LYS   A 1 157 ? -35.992 -33.340 -1.797  0.25 62.43  ? 420  LYS   A CG  1 
ATOM   1051 C  CD  . LYS   A 1 157 ? -36.905 -34.538 -1.997  0.25 62.56  ? 420  LYS   A CD  1 
ATOM   1052 C  CE  . LYS   A 1 157 ? -38.204 -34.444 -1.223  0.25 60.82  ? 420  LYS   A CE  1 
ATOM   1053 N  NZ  . LYS   A 1 157 ? -39.128 -35.547 -1.575  0.25 60.17  ? 420  LYS   A NZ  1 
ATOM   1054 N  N   . SER   A 1 158 ? -35.521 -31.713 -4.873  0.25 58.63  ? 421  SER   A N   1 
ATOM   1055 C  CA  . SER   A 1 158 ? -34.885 -32.161 -6.141  0.25 55.85  ? 421  SER   A CA  1 
ATOM   1056 C  C   . SER   A 1 158 ? -35.204 -31.172 -7.268  0.25 55.42  ? 421  SER   A C   1 
ATOM   1057 O  O   . SER   A 1 158 ? -36.173 -30.397 -7.128  0.25 52.63  ? 421  SER   A O   1 
ATOM   1058 C  CB  . SER   A 1 158 ? -35.323 -33.559 -6.502  0.25 55.12  ? 421  SER   A CB  1 
ATOM   1059 O  OG  . SER   A 1 158 ? -36.737 -33.645 -6.582  0.25 54.64  ? 421  SER   A OG  1 
ATOM   1060 N  N   . ALA   A 1 159 ? -34.424 -31.215 -8.352  0.25 55.73  ? 422  ALA   A N   1 
ATOM   1061 C  CA  . ALA   A 1 159 ? -34.616 -30.282 -9.488  0.25 54.27  ? 422  ALA   A CA  1 
ATOM   1062 C  C   . ALA   A 1 159 ? -35.969 -30.531 -10.161 0.25 53.27  ? 422  ALA   A C   1 
ATOM   1063 O  O   . ALA   A 1 159 ? -36.542 -29.573 -10.708 0.25 49.94  ? 422  ALA   A O   1 
ATOM   1064 C  CB  . ALA   A 1 159 ? -33.484 -30.449 -10.467 0.25 55.14  ? 422  ALA   A CB  1 
ATOM   1065 N  N   . ARG   A 1 160 ? -36.453 -31.773 -10.121 0.25 53.90  ? 423  ARG   A N   1 
ATOM   1066 C  CA  . ARG   A 1 160 ? -37.756 -32.111 -10.750 0.25 54.63  ? 423  ARG   A CA  1 
ATOM   1067 C  C   . ARG   A 1 160 ? -38.843 -31.218 -10.144 0.25 55.47  ? 423  ARG   A C   1 
ATOM   1068 O  O   . ARG   A 1 160 ? -39.646 -30.656 -10.912 0.25 54.97  ? 423  ARG   A O   1 
ATOM   1069 C  CB  . ARG   A 1 160 ? -38.065 -33.595 -10.542 0.25 56.16  ? 423  ARG   A CB  1 
ATOM   1070 C  CG  . ARG   A 1 160 ? -39.273 -34.097 -11.318 0.25 58.59  ? 423  ARG   A CG  1 
ATOM   1071 C  CD  . ARG   A 1 160 ? -39.513 -35.571 -11.053 0.25 61.37  ? 423  ARG   A CD  1 
ATOM   1072 N  NE  . ARG   A 1 160 ? -38.336 -36.378 -11.339 0.25 61.85  ? 423  ARG   A NE  1 
ATOM   1073 C  CZ  . ARG   A 1 160 ? -38.130 -37.034 -12.475 0.25 63.27  ? 423  ARG   A CZ  1 
ATOM   1074 N  NH1 . ARG   A 1 160 ? -37.025 -37.741 -12.641 0.25 62.71  ? 423  ARG   A NH1 1 
ATOM   1075 N  NH2 . ARG   A 1 160 ? -39.033 -36.988 -13.437 0.25 62.92  ? 423  ARG   A NH2 1 
ATOM   1076 N  N   . GLU   A 1 161 ? -38.846 -31.072 -8.817  0.25 54.24  ? 424  GLU   A N   1 
ATOM   1077 C  CA  . GLU   A 1 161 ? -39.849 -30.212 -8.138  0.25 52.68  ? 424  GLU   A CA  1 
ATOM   1078 C  C   . GLU   A 1 161 ? -39.677 -28.768 -8.614  0.25 50.00  ? 424  GLU   A C   1 
ATOM   1079 O  O   . GLU   A 1 161 ? -40.699 -28.114 -8.897  0.25 48.71  ? 424  GLU   A O   1 
ATOM   1080 C  CB  . GLU   A 1 161 ? -39.665 -30.286 -6.622  0.25 53.42  ? 424  GLU   A CB  1 
ATOM   1081 C  CG  . GLU   A 1 161 ? -39.497 -31.700 -6.100  0.25 54.02  ? 424  GLU   A CG  1 
ATOM   1082 C  CD  . GLU   A 1 161 ? -39.134 -31.787 -4.628  0.25 54.36  ? 424  GLU   A CD  1 
ATOM   1083 O  OE1 . GLU   A 1 161 ? -38.953 -30.724 -4.000  0.25 52.39  ? 424  GLU   A OE1 1 
ATOM   1084 O  OE2 . GLU   A 1 161 ? -39.033 -32.917 -4.112  0.25 53.70  ? 424  GLU   A OE2 1 
ATOM   1085 N  N   . ALA   A 1 162 ? -38.430 -28.297 -8.701  0.25 47.51  ? 425  ALA   A N   1 
ATOM   1086 C  CA  . ALA   A 1 162 ? -38.170 -26.893 -9.094  0.25 46.09  ? 425  ALA   A CA  1 
ATOM   1087 C  C   . ALA   A 1 162 ? -38.698 -26.635 -10.508 0.25 45.01  ? 425  ALA   A C   1 
ATOM   1088 O  O   . ALA   A 1 162 ? -39.365 -25.602 -10.705 0.25 43.01  ? 425  ALA   A O   1 
ATOM   1089 C  CB  . ALA   A 1 162 ? -36.693 -26.606 -9.001  0.25 45.46  ? 425  ALA   A CB  1 
ATOM   1090 N  N   . VAL   A 1 163 ? -38.414 -27.538 -11.449 0.25 44.34  ? 426  VAL   A N   1 
ATOM   1091 C  CA  . VAL   A 1 163 ? -38.824 -27.313 -12.868 0.25 45.96  ? 426  VAL   A CA  1 
ATOM   1092 C  C   . VAL   A 1 163 ? -40.353 -27.299 -12.937 0.25 46.51  ? 426  VAL   A C   1 
ATOM   1093 O  O   . VAL   A 1 163 ? -40.895 -26.634 -13.837 0.25 45.51  ? 426  VAL   A O   1 
ATOM   1094 C  CB  . VAL   A 1 163 ? -38.219 -28.369 -13.815 0.25 45.57  ? 426  VAL   A CB  1 
ATOM   1095 C  CG1 . VAL   A 1 163 ? -36.700 -28.386 -13.743 0.25 44.95  ? 426  VAL   A CG1 1 
ATOM   1096 C  CG2 . VAL   A 1 163 ? -38.785 -29.757 -13.566 0.25 47.05  ? 426  VAL   A CG2 1 
ATOM   1097 N  N   . GLU   A 1 164 ? -41.011 -28.013 -12.021 0.25 49.23  ? 427  GLU   A N   1 
ATOM   1098 C  CA  . GLU   A 1 164 ? -42.496 -28.066 -12.000 0.25 51.84  ? 427  GLU   A CA  1 
ATOM   1099 C  C   . GLU   A 1 164 ? -43.052 -26.784 -11.370 0.25 52.96  ? 427  GLU   A C   1 
ATOM   1100 O  O   . GLU   A 1 164 ? -44.217 -26.449 -11.655 0.25 55.90  ? 427  GLU   A O   1 
ATOM   1101 C  CB  . GLU   A 1 164 ? -42.954 -29.306 -11.233 0.25 52.14  ? 427  GLU   A CB  1 
ATOM   1102 C  CG  . GLU   A 1 164 ? -42.521 -30.606 -11.886 0.25 53.20  ? 427  GLU   A CG  1 
ATOM   1103 C  CD  . GLU   A 1 164 ? -42.599 -31.823 -10.981 0.25 55.35  ? 427  GLU   A CD  1 
ATOM   1104 O  OE1 . GLU   A 1 164 ? -42.806 -31.641 -9.765  0.25 57.22  ? 427  GLU   A OE1 1 
ATOM   1105 O  OE2 . GLU   A 1 164 ? -42.452 -32.951 -11.494 0.25 55.20  ? 427  GLU   A OE2 1 
ATOM   1106 N  N   . ASP   A 1 165 ? -42.250 -26.093 -10.555 0.25 52.78  ? 428  ASP   A N   1 
ATOM   1107 C  CA  . ASP   A 1 165 ? -42.737 -24.878 -9.847  0.25 52.06  ? 428  ASP   A CA  1 
ATOM   1108 C  C   . ASP   A 1 165 ? -42.492 -23.631 -10.703 0.25 51.93  ? 428  ASP   A C   1 
ATOM   1109 O  O   . ASP   A 1 165 ? -41.332 -23.401 -11.088 0.25 49.81  ? 428  ASP   A O   1 
ATOM   1110 C  CB  . ASP   A 1 165 ? -42.083 -24.740 -8.470  0.25 51.77  ? 428  ASP   A CB  1 
ATOM   1111 C  CG  . ASP   A 1 165 ? -42.524 -23.506 -7.700  0.25 51.27  ? 428  ASP   A CG  1 
ATOM   1112 O  OD1 . ASP   A 1 165 ? -43.376 -22.761 -8.219  0.25 48.24  ? 428  ASP   A OD1 1 
ATOM   1113 O  OD2 . ASP   A 1 165 ? -42.011 -23.301 -6.584  0.25 52.77  ? 428  ASP   A OD2 1 
ATOM   1114 N  N   . SER   A 1 166 ? -43.545 -22.850 -10.962 0.25 53.10  ? 429  SER   A N   1 
ATOM   1115 C  CA  . SER   A 1 166 ? -43.402 -21.584 -11.734 0.25 52.69  ? 429  SER   A CA  1 
ATOM   1116 C  C   . SER   A 1 166 ? -42.531 -20.581 -10.965 0.25 51.66  ? 429  SER   A C   1 
ATOM   1117 O  O   . SER   A 1 166 ? -41.880 -19.754 -11.625 0.25 51.60  ? 429  SER   A O   1 
ATOM   1118 C  CB  . SER   A 1 166 ? -44.750 -20.995 -12.065 0.25 54.49  ? 429  SER   A CB  1 
ATOM   1119 O  OG  . SER   A 1 166 ? -45.482 -21.857 -12.926 0.25 55.86  ? 429  SER   A OG  1 
ATOM   1120 N  N   . GLY   A 1 167 ? -42.529 -20.654 -9.628  0.25 53.44  ? 430  GLY   A N   1 
ATOM   1121 C  CA  . GLY   A 1 167 ? -41.707 -19.817 -8.729  0.25 52.08  ? 430  GLY   A CA  1 
ATOM   1122 C  C   . GLY   A 1 167 ? -40.232 -19.866 -9.091  0.25 51.76  ? 430  GLY   A C   1 
ATOM   1123 O  O   . GLY   A 1 167 ? -39.598 -18.796 -9.121  0.25 50.65  ? 430  GLY   A O   1 
ATOM   1124 N  N   . PHE   A 1 168 ? -39.703 -21.066 -9.353  0.25 51.11  ? 431  PHE   A N   1 
ATOM   1125 C  CA  . PHE   A 1 168 ? -38.321 -21.295 -9.855  0.25 50.25  ? 431  PHE   A CA  1 
ATOM   1126 C  C   . PHE   A 1 168 ? -38.100 -20.475 -11.129 0.25 47.93  ? 431  PHE   A C   1 
ATOM   1127 O  O   . PHE   A 1 168 ? -37.160 -19.662 -11.172 0.25 47.41  ? 431  PHE   A O   1 
ATOM   1128 C  CB  . PHE   A 1 168 ? -38.077 -22.780 -10.132 0.25 50.79  ? 431  PHE   A CB  1 
ATOM   1129 C  CG  . PHE   A 1 168 ? -36.827 -23.070 -10.925 0.25 50.44  ? 431  PHE   A CG  1 
ATOM   1130 C  CD1 . PHE   A 1 168 ? -35.574 -22.813 -10.390 0.25 50.48  ? 431  PHE   A CD1 1 
ATOM   1131 C  CD2 . PHE   A 1 168 ? -36.904 -23.596 -12.206 0.25 51.15  ? 431  PHE   A CD2 1 
ATOM   1132 C  CE1 . PHE   A 1 168 ? -34.424 -23.080 -11.118 0.25 50.98  ? 431  PHE   A CE1 1 
ATOM   1133 C  CE2 . PHE   A 1 168 ? -35.753 -23.863 -12.934 0.25 50.65  ? 431  PHE   A CE2 1 
ATOM   1134 C  CZ  . PHE   A 1 168 ? -34.516 -23.603 -12.388 0.25 51.95  ? 431  PHE   A CZ  1 
ATOM   1135 N  N   . TRP   A 1 169 ? -38.964 -20.671 -12.130 0.25 47.28  ? 432  TRP   A N   1 
ATOM   1136 C  CA  . TRP   A 1 169 ? -38.889 -19.978 -13.445 0.25 45.62  ? 432  TRP   A CA  1 
ATOM   1137 C  C   . TRP   A 1 169 ? -39.025 -18.461 -13.254 0.25 46.34  ? 432  TRP   A C   1 
ATOM   1138 O  O   . TRP   A 1 169 ? -38.492 -17.717 -14.101 0.25 46.32  ? 432  TRP   A O   1 
ATOM   1139 C  CB  . TRP   A 1 169 ? -39.930 -20.547 -14.415 0.25 44.79  ? 432  TRP   A CB  1 
ATOM   1140 C  CG  . TRP   A 1 169 ? -39.652 -21.972 -14.778 0.25 45.02  ? 432  TRP   A CG  1 
ATOM   1141 C  CD1 . TRP   A 1 169 ? -40.396 -23.066 -14.446 0.25 44.98  ? 432  TRP   A CD1 1 
ATOM   1142 C  CD2 . TRP   A 1 169 ? -38.509 -22.470 -15.500 0.25 44.66  ? 432  TRP   A CD2 1 
ATOM   1143 N  NE1 . TRP   A 1 169 ? -39.811 -24.205 -14.930 0.25 44.91  ? 432  TRP   A NE1 1 
ATOM   1144 C  CE2 . TRP   A 1 169 ? -38.651 -23.872 -15.580 0.25 44.48  ? 432  TRP   A CE2 1 
ATOM   1145 C  CE3 . TRP   A 1 169 ? -37.392 -21.871 -16.096 0.25 44.72  ? 432  TRP   A CE3 1 
ATOM   1146 C  CZ2 . TRP   A 1 169 ? -37.718 -24.678 -16.233 0.25 45.30  ? 432  TRP   A CZ2 1 
ATOM   1147 C  CZ3 . TRP   A 1 169 ? -36.472 -22.669 -16.742 0.25 45.05  ? 432  TRP   A CZ3 1 
ATOM   1148 C  CH2 . TRP   A 1 169 ? -36.634 -24.053 -16.807 0.25 44.83  ? 432  TRP   A CH2 1 
ATOM   1149 N  N   . GLU   A 1 170 ? -39.693 -18.022 -12.179 0.25 46.10  ? 433  GLU   A N   1 
ATOM   1150 C  CA  . GLU   A 1 170 ? -39.772 -16.591 -11.775 0.25 46.01  ? 433  GLU   A CA  1 
ATOM   1151 C  C   . GLU   A 1 170 ? -38.369 -16.123 -11.357 0.25 46.33  ? 433  GLU   A C   1 
ATOM   1152 O  O   . GLU   A 1 170 ? -37.995 -14.991 -11.718 0.25 46.57  ? 433  GLU   A O   1 
ATOM   1153 C  CB  . GLU   A 1 170 ? -40.814 -16.387 -10.666 0.25 44.03  ? 433  GLU   A CB  1 
ATOM   1154 C  CG  . GLU   A 1 170 ? -42.246 -16.681 -11.101 0.25 42.42  ? 433  GLU   A CG  1 
ATOM   1155 C  CD  . GLU   A 1 170 ? -43.269 -16.836 -9.982  0.25 41.58  ? 433  GLU   A CD  1 
ATOM   1156 O  OE1 . GLU   A 1 170 ? -43.229 -16.030 -9.026  0.25 39.23  ? 433  GLU   A OE1 1 
ATOM   1157 O  OE2 . GLU   A 1 170 ? -44.113 -17.763 -10.067 0.25 38.63  ? 433  GLU   A OE2 1 
ATOM   1158 N  N   . LEU   A 1 171 ? -37.614 -16.969 -10.645 0.25 49.01  ? 434  LEU   A N   1 
ATOM   1159 C  CA  . LEU   A 1 171 ? -36.223 -16.671 -10.198 0.25 51.33  ? 434  LEU   A CA  1 
ATOM   1160 C  C   . LEU   A 1 171 ? -35.294 -16.650 -11.419 0.25 52.52  ? 434  LEU   A C   1 
ATOM   1161 O  O   . LEU   A 1 171 ? -34.444 -15.738 -11.500 0.25 52.71  ? 434  LEU   A O   1 
ATOM   1162 C  CB  . LEU   A 1 171 ? -35.757 -17.713 -9.173  0.25 51.11  ? 434  LEU   A CB  1 
ATOM   1163 C  CG  . LEU   A 1 171 ? -36.641 -17.897 -7.938  0.25 52.23  ? 434  LEU   A CG  1 
ATOM   1164 C  CD1 . LEU   A 1 171 ? -36.039 -18.929 -6.995  0.25 53.18  ? 434  LEU   A CD1 1 
ATOM   1165 C  CD2 . LEU   A 1 171 ? -36.861 -16.578 -7.211  0.25 52.37  ? 434  LEU   A CD2 1 
ATOM   1166 N  N   . VAL   A 1 172 ? -35.469 -17.612 -12.333 0.25 54.85  ? 435  VAL   A N   1 
ATOM   1167 C  CA  . VAL   A 1 172 ? -34.700 -17.734 -13.610 0.25 56.21  ? 435  VAL   A CA  1 
ATOM   1168 C  C   . VAL   A 1 172 ? -34.904 -16.455 -14.431 0.25 56.80  ? 435  VAL   A C   1 
ATOM   1169 O  O   . VAL   A 1 172 ? -33.895 -15.873 -14.874 0.25 57.13  ? 435  VAL   A O   1 
ATOM   1170 C  CB  . VAL   A 1 172 ? -35.119 -18.989 -14.401 0.25 56.55  ? 435  VAL   A CB  1 
ATOM   1171 C  CG1 . VAL   A 1 172 ? -34.488 -19.025 -15.786 0.25 57.11  ? 435  VAL   A CG1 1 
ATOM   1172 C  CG2 . VAL   A 1 172 ? -34.806 -20.270 -13.639 0.25 56.20  ? 435  VAL   A CG2 1 
ATOM   1173 N  N   . ASP   A 1 173 ? -36.163 -16.037 -14.609 1.00 60.84  ? 436  ASP   A N   1 
ATOM   1174 C  CA  . ASP   A 1 173 ? -36.525 -14.782 -15.340 1.00 64.21  ? 436  ASP   A CA  1 
ATOM   1175 C  C   . ASP   A 1 173 ? -35.771 -13.581 -14.750 1.00 59.69  ? 436  ASP   A C   1 
ATOM   1176 O  O   . ASP   A 1 173 ? -35.180 -12.806 -15.539 1.00 61.85  ? 436  ASP   A O   1 
ATOM   1177 C  CB  . ASP   A 1 173 ? -38.038 -14.512 -15.341 1.00 80.37  ? 436  ASP   A CB  1 
ATOM   1178 C  CG  . ASP   A 1 173 ? -38.848 -15.388 -16.290 1.00 85.97  ? 436  ASP   A CG  1 
ATOM   1179 O  OD1 . ASP   A 1 173 ? -38.378 -15.597 -17.444 1.00 86.40  ? 436  ASP   A OD1 1 
ATOM   1180 O  OD2 . ASP   A 1 173 ? -39.939 -15.879 -15.865 1.00 87.60  ? 436  ASP   A OD2 1 
ATOM   1181 N  N   . LYS   A 1 174 ? -35.748 -13.414 -13.424 1.00 64.52  ? 437  LYS   A N   1 
ATOM   1182 C  CA  . LYS   A 1 174 ? -35.086 -12.220 -12.821 1.00 65.84  ? 437  LYS   A CA  1 
ATOM   1183 C  C   . LYS   A 1 174 ? -33.622 -12.202 -13.279 1.00 63.43  ? 437  LYS   A C   1 
ATOM   1184 O  O   . LYS   A 1 174 ? -33.160 -11.145 -13.765 1.00 71.12  ? 437  LYS   A O   1 
ATOM   1185 C  CB  . LYS   A 1 174 ? -35.201 -12.210 -11.292 1.00 72.75  ? 437  LYS   A CB  1 
ATOM   1186 C  CG  . LYS   A 1 174 ? -34.790 -10.898 -10.628 1.00 77.14  ? 437  LYS   A CG  1 
ATOM   1187 C  CD  . LYS   A 1 174 ? -34.833 -10.925 -9.094  1.00 77.88  ? 437  LYS   A CD  1 
ATOM   1188 C  CE  . LYS   A 1 174 ? -34.131 -9.749  -8.445  1.00 79.27  ? 437  LYS   A CE  1 
ATOM   1189 N  NZ  . LYS   A 1 174 ? -34.257 -9.800  -6.969  1.00 88.89  ? 437  LYS   A NZ  1 
ATOM   1190 N  N   . GLU   A 1 175 ? -32.921 -13.337 -13.154 1.00 66.30  ? 438  GLU   A N   1 
ATOM   1191 C  CA  . GLU   A 1 175 ? -31.489 -13.452 -13.538 1.00 62.30  ? 438  GLU   A CA  1 
ATOM   1192 C  C   . GLU   A 1 175 ? -31.373 -13.252 -15.049 1.00 56.82  ? 438  GLU   A C   1 
ATOM   1193 O  O   . GLU   A 1 175 ? -30.494 -12.470 -15.475 1.00 57.41  ? 438  GLU   A O   1 
ATOM   1194 C  CB  . GLU   A 1 175 ? -30.911 -14.793 -13.097 1.00 64.57  ? 438  GLU   A CB  1 
ATOM   1195 C  CG  . GLU   A 1 175 ? -30.129 -14.677 -11.802 1.00 73.88  ? 438  GLU   A CG  1 
ATOM   1196 C  CD  . GLU   A 1 175 ? -28.710 -14.163 -11.949 1.00 63.78  ? 438  GLU   A CD  1 
ATOM   1197 O  OE1 . GLU   A 1 175 ? -27.805 -14.978 -12.193 1.00 71.05  ? 438  GLU   A OE1 1 
ATOM   1198 O  OE2 . GLU   A 1 175 ? -28.512 -12.956 -11.805 1.00 72.26  ? 438  GLU   A OE2 1 
ATOM   1199 N  N   . ARG   A 1 176 ? -32.249 -13.910 -15.817 1.00 59.14  ? 439  ARG   A N   1 
ATOM   1200 C  CA  . ARG   A 1 176 ? -32.251 -13.823 -17.297 1.00 53.39  ? 439  ARG   A CA  1 
ATOM   1201 C  C   . ARG   A 1 176 ? -32.208 -12.344 -17.682 1.00 60.24  ? 439  ARG   A C   1 
ATOM   1202 O  O   . ARG   A 1 176 ? -31.298 -11.975 -18.450 1.00 58.39  ? 439  ARG   A O   1 
ATOM   1203 C  CB  . ARG   A 1 176 ? -33.449 -14.582 -17.864 1.00 58.64  ? 439  ARG   A CB  1 
ATOM   1204 C  CG  . ARG   A 1 176 ? -33.420 -14.704 -19.381 1.00 58.84  ? 439  ARG   A CG  1 
ATOM   1205 C  CD  . ARG   A 1 176 ? -34.166 -15.935 -19.833 1.00 54.21  ? 439  ARG   A CD  1 
ATOM   1206 N  NE  . ARG   A 1 176 ? -34.272 -15.887 -21.274 1.00 67.62  ? 439  ARG   A NE  1 
ATOM   1207 C  CZ  . ARG   A 1 176 ? -34.934 -16.760 -22.016 1.00 77.87  ? 439  ARG   A CZ  1 
ATOM   1208 N  NH1 . ARG   A 1 176 ? -35.545 -17.782 -21.433 1.00 85.21  ? 439  ARG   A NH1 1 
ATOM   1209 N  NH2 . ARG   A 1 176 ? -34.965 -16.608 -23.333 1.00 75.16  ? 439  ARG   A NH2 1 
ATOM   1210 N  N   . ASN   A 1 177 ? -33.074 -11.506 -17.084 1.00 64.89  ? 440  ASN   A N   1 
ATOM   1211 C  CA  . ASN   A 1 177 ? -33.154 -10.046 -17.391 1.00 64.88  ? 440  ASN   A CA  1 
ATOM   1212 C  C   . ASN   A 1 177 ? -31.919 -9.315  -16.852 1.00 61.99  ? 440  ASN   A C   1 
ATOM   1213 O  O   . ASN   A 1 177 ? -31.466 -8.363  -17.514 1.00 64.86  ? 440  ASN   A O   1 
ATOM   1214 C  CB  . ASN   A 1 177 ? -34.487 -9.436  -16.942 1.00 67.89  ? 440  ASN   A CB  1 
ATOM   1215 C  CG  . ASN   A 1 177 ? -35.590 -9.854  -17.892 1.00 69.82  ? 440  ASN   A CG  1 
ATOM   1216 O  OD1 . ASN   A 1 177 ? -35.721 -9.316  -18.995 1.00 78.78  ? 440  ASN   A OD1 1 
ATOM   1217 N  ND2 . ASN   A 1 177 ? -36.329 -10.878 -17.516 1.00 65.64  ? 440  ASN   A ND2 1 
ATOM   1218 N  N   . LEU   A 1 178 ? -31.350 -9.766  -15.734 1.00 67.13  ? 441  LEU   A N   1 
ATOM   1219 C  CA  . LEU   A 1 178 ? -30.049 -9.249  -15.229 1.00 63.86  ? 441  LEU   A CA  1 
ATOM   1220 C  C   . LEU   A 1 178 ? -28.929 -9.454  -16.264 1.00 65.71  ? 441  LEU   A C   1 
ATOM   1221 O  O   . LEU   A 1 178 ? -28.178 -8.480  -16.511 1.00 63.66  ? 441  LEU   A O   1 
ATOM   1222 C  CB  . LEU   A 1 178 ? -29.735 -9.919  -13.889 1.00 69.96  ? 441  LEU   A CB  1 
ATOM   1223 C  CG  . LEU   A 1 178 ? -30.512 -9.330  -12.709 1.00 77.73  ? 441  LEU   A CG  1 
ATOM   1224 C  CD1 . LEU   A 1 178 ? -30.306 -10.142 -11.432 1.00 81.43  ? 441  LEU   A CD1 1 
ATOM   1225 C  CD2 . LEU   A 1 178 ? -30.117 -7.874  -12.490 1.00 81.99  ? 441  LEU   A CD2 1 
ATOM   1226 N  N   . HIS   A 1 179 ? -28.808 -10.645 -16.864 1.00 62.85  ? 442  HIS   A N   1 
ATOM   1227 C  CA  . HIS   A 1 179 ? -27.782 -10.937 -17.913 1.00 64.03  ? 442  HIS   A CA  1 
ATOM   1228 C  C   . HIS   A 1 179 ? -27.987 -10.054 -19.162 1.00 62.86  ? 442  HIS   A C   1 
ATOM   1229 O  O   . HIS   A 1 179 ? -26.984 -9.504  -19.649 1.00 63.47  ? 442  HIS   A O   1 
ATOM   1230 C  CB  . HIS   A 1 179 ? -27.751 -12.435 -18.276 1.00 64.10  ? 442  HIS   A CB  1 
ATOM   1231 C  CG  . HIS   A 1 179 ? -27.263 -13.332 -17.183 1.00 55.01  ? 442  HIS   A CG  1 
ATOM   1232 N  ND1 . HIS   A 1 179 ? -27.391 -14.706 -17.245 1.00 53.31  ? 442  HIS   A ND1 1 
ATOM   1233 C  CD2 . HIS   A 1 179 ? -26.672 -13.049 -16.003 1.00 50.98  ? 442  HIS   A CD2 1 
ATOM   1234 C  CE1 . HIS   A 1 179 ? -26.932 -15.225 -16.127 1.00 54.77  ? 442  HIS   A CE1 1 
ATOM   1235 N  NE2 . HIS   A 1 179 ? -26.479 -14.221 -15.352 1.00 52.25  ? 442  HIS   A NE2 1 
ATOM   1236 N  N   . LEU   A 1 180 ? -29.226 -9.888  -19.662 1.00 77.38  ? 443  LEU   A N   1 
ATOM   1237 C  CA  . LEU   A 1 180 ? -29.534 -8.989  -20.823 1.00 68.96  ? 443  LEU   A CA  1 
ATOM   1238 C  C   . LEU   A 1 180 ? -29.061 -7.566  -20.489 1.00 65.15  ? 443  LEU   A C   1 
ATOM   1239 O  O   . LEU   A 1 180 ? -28.650 -6.834  -21.406 1.00 70.10  ? 443  LEU   A O   1 
ATOM   1240 C  CB  . LEU   A 1 180 ? -31.031 -9.035  -21.162 1.00 68.04  ? 443  LEU   A CB  1 
ATOM   1241 C  CG  . LEU   A 1 180 ? -31.579 -10.379 -21.655 1.00 66.90  ? 443  LEU   A CG  1 
ATOM   1242 C  CD1 . LEU   A 1 180 ? -33.100 -10.401 -21.626 1.00 69.91  ? 443  LEU   A CD1 1 
ATOM   1243 C  CD2 . LEU   A 1 180 ? -31.100 -10.713 -23.056 1.00 69.00  ? 443  LEU   A CD2 1 
ATOM   1244 N  N   . GLU   A 1 181 ? -29.024 -7.227  -19.203 1.00 72.55  ? 444  GLU   A N   1 
ATOM   1245 C  CA  . GLU   A 1 181 ? -28.559 -5.919  -18.672 1.00 82.17  ? 444  GLU   A CA  1 
ATOM   1246 C  C   . GLU   A 1 181 ? -27.039 -5.948  -18.419 1.00 80.38  ? 444  GLU   A C   1 
ATOM   1247 O  O   . GLU   A 1 181 ? -26.477 -4.886  -18.044 1.00 74.24  ? 444  GLU   A O   1 
ATOM   1248 C  CB  . GLU   A 1 181 ? -29.360 -5.623  -17.399 1.00 93.73  ? 444  GLU   A CB  1 
ATOM   1249 C  CG  . GLU   A 1 181 ? -29.749 -4.169  -17.207 1.00 96.05  ? 444  GLU   A CG  1 
ATOM   1250 C  CD  . GLU   A 1 181 ? -30.290 -3.876  -15.814 1.00 102.56 ? 444  GLU   A CD  1 
ATOM   1251 O  OE1 . GLU   A 1 181 ? -30.137 -2.723  -15.353 1.00 99.38  ? 444  GLU   A OE1 1 
ATOM   1252 O  OE2 . GLU   A 1 181 ? -30.849 -4.810  -15.181 1.00 96.08  ? 444  GLU   A OE2 1 
ATOM   1253 N  N   . GLY   A 1 182 ? -26.383 -7.103  -18.601 1.00 76.23  ? 445  GLY   A N   1 
ATOM   1254 C  CA  . GLY   A 1 182 ? -24.914 -7.241  -18.485 1.00 68.55  ? 445  GLY   A CA  1 
ATOM   1255 C  C   . GLY   A 1 182 ? -24.427 -7.305  -17.042 1.00 63.82  ? 445  GLY   A C   1 
ATOM   1256 O  O   . GLY   A 1 182 ? -23.298 -6.863  -16.793 1.00 74.68  ? 445  GLY   A O   1 
ATOM   1257 N  N   . LYS   A 1 183 ? -25.237 -7.859  -16.132 1.00 61.63  ? 446  LYS   A N   1 
ATOM   1258 C  CA  . LYS   A 1 183 ? -24.989 -7.968  -14.662 1.00 64.89  ? 446  LYS   A CA  1 
ATOM   1259 C  C   . LYS   A 1 183 ? -25.451 -9.354  -14.169 1.00 49.40  ? 446  LYS   A C   1 
ATOM   1260 O  O   . LYS   A 1 183 ? -26.306 -9.940  -14.817 1.00 51.61  ? 446  LYS   A O   1 
ATOM   1261 C  CB  . LYS   A 1 183 ? -25.790 -6.924  -13.863 1.00 73.09  ? 446  LYS   A CB  1 
ATOM   1262 C  CG  . LYS   A 1 183 ? -25.693 -5.472  -14.323 1.00 75.46  ? 446  LYS   A CG  1 
ATOM   1263 C  CD  . LYS   A 1 183 ? -26.947 -4.671  -14.003 1.00 80.29  ? 446  LYS   A CD  1 
ATOM   1264 C  CE  . LYS   A 1 183 ? -26.955 -3.291  -14.629 1.00 85.30  ? 446  LYS   A CE  1 
ATOM   1265 N  NZ  . LYS   A 1 183 ? -26.797 -2.219  -13.619 1.00 90.26  ? 446  LYS   A NZ  1 
ATOM   1266 N  N   . CYS   A 1 184 ? -24.980 -9.805  -13.002 1.00 56.79  ? 447  CYS   A N   1 
ATOM   1267 C  CA  . CYS   A 1 184 ? -25.197 -11.175 -12.447 1.00 55.64  ? 447  CYS   A CA  1 
ATOM   1268 C  C   . CYS   A 1 184 ? -25.412 -11.094 -10.926 1.00 55.60  ? 447  CYS   A C   1 
ATOM   1269 O  O   . CYS   A 1 184 ? -24.682 -10.310 -10.274 1.00 58.93  ? 447  CYS   A O   1 
ATOM   1270 C  CB  . CYS   A 1 184 ? -23.971 -12.039 -12.783 1.00 58.69  ? 447  CYS   A CB  1 
ATOM   1271 S  SG  . CYS   A 1 184 ? -24.199 -13.820 -12.512 1.00 50.75  ? 447  CYS   A SG  1 
ATOM   1272 N  N   . GLU   A 1 185 ? -26.278 -11.944 -10.359 1.00 58.37  ? 448  GLU   A N   1 
ATOM   1273 C  CA  . GLU   A 1 185 ? -26.596 -11.934 -8.903  1.00 64.78  ? 448  GLU   A CA  1 
ATOM   1274 C  C   . GLU   A 1 185 ? -26.478 -13.326 -8.274  1.00 65.50  ? 448  GLU   A C   1 
ATOM   1275 O  O   . GLU   A 1 185 ? -26.063 -13.392 -7.097  1.00 66.97  ? 448  GLU   A O   1 
ATOM   1276 C  CB  . GLU   A 1 185 ? -28.007 -11.386 -8.665  1.00 77.22  ? 448  GLU   A CB  1 
ATOM   1277 C  CG  . GLU   A 1 185 ? -28.257 -10.945 -7.231  1.00 78.16  ? 448  GLU   A CG  1 
ATOM   1278 C  CD  . GLU   A 1 185 ? -29.662 -10.444 -6.937  1.00 84.75  ? 448  GLU   A CD  1 
ATOM   1279 O  OE1 . GLU   A 1 185 ? -29.797 -9.223  -6.731  1.00 85.18  ? 448  GLU   A OE1 1 
ATOM   1280 O  OE2 . GLU   A 1 185 ? -30.618 -11.273 -6.909  1.00 83.65  ? 448  GLU   A OE2 1 
ATOM   1281 N  N   . THR   A 1 186 ? -26.877 -14.396 -8.963  1.00 58.83  ? 449  THR   A N   1 
ATOM   1282 C  CA  . THR   A 1 186 ? -27.004 -15.727 -8.321  1.00 60.52  ? 449  THR   A CA  1 
ATOM   1283 C  C   . THR   A 1 186 ? -26.146 -16.795 -9.009  1.00 56.48  ? 449  THR   A C   1 
ATOM   1284 O  O   . THR   A 1 186 ? -26.185 -17.926 -8.512  1.00 61.74  ? 449  THR   A O   1 
ATOM   1285 C  CB  . THR   A 1 186 ? -28.473 -16.159 -8.264  1.00 69.39  ? 449  THR   A CB  1 
ATOM   1286 O  OG1 . THR   A 1 186 ? -28.949 -16.290 -9.602  1.00 71.52  ? 449  THR   A OG1 1 
ATOM   1287 C  CG2 . THR   A 1 186 ? -29.353 -15.178 -7.526  1.00 71.44  ? 449  THR   A CG2 1 
ATOM   1288 N  N   . CYS   A 1 187 ? -25.399 -16.480 -10.076 1.00 52.86  ? 450  CYS   A N   1 
ATOM   1289 C  CA  . CYS   A 1 187 ? -24.552 -17.475 -10.813 1.00 48.04  ? 450  CYS   A CA  1 
ATOM   1290 C  C   . CYS   A 1 187 ? -23.193 -17.640 -10.097 1.00 46.13  ? 450  CYS   A C   1 
ATOM   1291 O  O   . CYS   A 1 187 ? -22.153 -17.046 -10.547 1.00 43.35  ? 450  CYS   A O   1 
ATOM   1292 C  CB  . CYS   A 1 187 ? -24.439 -17.086 -12.285 1.00 51.12  ? 450  CYS   A CB  1 
ATOM   1293 S  SG  . CYS   A 1 187 ? -26.067 -16.816 -13.053 1.00 50.62  ? 450  CYS   A SG  1 
ATOM   1294 N  N   . VAL   A 1 188 ? -23.194 -18.475 -9.055  1.00 46.57  ? 451  VAL   A N   1 
ATOM   1295 C  CA  . VAL   A 1 188 ? -22.059 -18.712 -8.109  1.00 53.28  ? 451  VAL   A CA  1 
ATOM   1296 C  C   . VAL   A 1 188 ? -21.685 -20.200 -8.088  1.00 48.97  ? 451  VAL   A C   1 
ATOM   1297 O  O   . VAL   A 1 188 ? -22.564 -21.051 -7.944  1.00 45.50  ? 451  VAL   A O   1 
ATOM   1298 C  CB  . VAL   A 1 188 ? -22.426 -18.228 -6.692  1.00 60.41  ? 451  VAL   A CB  1 
ATOM   1299 C  CG1 . VAL   A 1 188 ? -21.519 -18.827 -5.615  1.00 62.85  ? 451  VAL   A CG1 1 
ATOM   1300 C  CG2 . VAL   A 1 188 ? -22.411 -16.711 -6.634  1.00 65.03  ? 451  VAL   A CG2 1 
ATOM   1301 N  N   . TYR   A 1 189 ? -20.393 -20.503 -8.185  1.00 54.91  ? 452  TYR   A N   1 
ATOM   1302 C  CA  . TYR   A 1 189 ? -19.885 -21.902 -8.159  1.00 59.22  ? 452  TYR   A CA  1 
ATOM   1303 C  C   . TYR   A 1 189 ? -19.739 -22.371 -6.708  1.00 59.23  ? 452  TYR   A C   1 
ATOM   1304 O  O   . TYR   A 1 189 ? -19.570 -21.527 -5.816  1.00 67.76  ? 452  TYR   A O   1 
ATOM   1305 C  CB  . TYR   A 1 189 ? -18.602 -22.000 -8.977  1.00 58.15  ? 452  TYR   A CB  1 
ATOM   1306 C  CG  . TYR   A 1 189 ? -18.848 -21.871 -10.457 1.00 58.70  ? 452  TYR   A CG  1 
ATOM   1307 C  CD1 . TYR   A 1 189 ? -19.519 -22.863 -11.160 1.00 64.07  ? 452  TYR   A CD1 1 
ATOM   1308 C  CD2 . TYR   A 1 189 ? -18.447 -20.743 -11.151 1.00 60.77  ? 452  TYR   A CD2 1 
ATOM   1309 C  CE1 . TYR   A 1 189 ? -19.760 -22.740 -12.521 1.00 68.40  ? 452  TYR   A CE1 1 
ATOM   1310 C  CE2 . TYR   A 1 189 ? -18.660 -20.613 -12.516 1.00 62.98  ? 452  TYR   A CE2 1 
ATOM   1311 C  CZ  . TYR   A 1 189 ? -19.327 -21.613 -13.202 1.00 62.41  ? 452  TYR   A CZ  1 
ATOM   1312 O  OH  . TYR   A 1 189 ? -19.562 -21.467 -14.540 1.00 72.85  ? 452  TYR   A OH  1 
ATOM   1313 N  N   . ASN   A 1 190 ? -19.927 -23.671 -6.494  1.00 64.72  ? 453  ASN   A N   1 
ATOM   1314 C  CA  . ASN   A 1 190 ? -19.676 -24.413 -5.227  1.00 69.82  ? 453  ASN   A CA  1 
ATOM   1315 C  C   . ASN   A 1 190 ? -18.672 -25.544 -5.495  1.00 64.87  ? 453  ASN   A C   1 
ATOM   1316 O  O   . ASN   A 1 190 ? -19.017 -26.410 -6.289  1.00 59.84  ? 453  ASN   A O   1 
ATOM   1317 C  CB  . ASN   A 1 190 ? -20.971 -24.998 -4.671  1.00 68.87  ? 453  ASN   A CB  1 
ATOM   1318 C  CG  . ASN   A 1 190 ? -22.020 -23.944 -4.394  1.00 70.17  ? 453  ASN   A CG  1 
ATOM   1319 O  OD1 . ASN   A 1 190 ? -22.122 -22.937 -5.091  1.00 89.28  ? 453  ASN   A OD1 1 
ATOM   1320 N  ND2 . ASN   A 1 190 ? -22.821 -24.177 -3.374  1.00 74.10  ? 453  ASN   A ND2 1 
ATOM   1321 N  N   . MET   A 1 191 ? -17.481 -25.519 -4.882  1.00 80.79  ? 454  MET   A N   1 
ATOM   1322 C  CA  . MET   A 1 191 ? -16.372 -26.482 -5.155  1.00 90.48  ? 454  MET   A CA  1 
ATOM   1323 C  C   . MET   A 1 191 ? -16.585 -27.749 -4.316  1.00 96.86  ? 454  MET   A C   1 
ATOM   1324 O  O   . MET   A 1 191 ? -17.250 -27.634 -3.264  1.00 95.47  ? 454  MET   A O   1 
ATOM   1325 C  CB  . MET   A 1 191 ? -15.010 -25.863 -4.827  1.00 96.42  ? 454  MET   A CB  1 
ATOM   1326 C  CG  . MET   A 1 191 ? -13.832 -26.628 -5.408  1.00 110.81 ? 454  MET   A CG  1 
ATOM   1327 S  SD  . MET   A 1 191 ? -12.488 -25.565 -6.025  1.00 124.16 ? 454  MET   A SD  1 
ATOM   1328 C  CE  . MET   A 1 191 ? -13.098 -25.197 -7.671  1.00 119.19 ? 454  MET   A CE  1 
ATOM   1329 N  N   . MET   A 1 192 ? -16.085 -28.905 -4.792  1.00 110.74 ? 455  MET   A N   1 
ATOM   1330 C  CA  . MET   A 1 192 ? -16.200 -30.249 -4.137  1.00 111.15 ? 455  MET   A CA  1 
ATOM   1331 C  C   . MET   A 1 192 ? -15.382 -31.312 -4.894  1.00 110.42 ? 455  MET   A C   1 
ATOM   1332 O  O   . MET   A 1 192 ? -15.474 -31.359 -6.143  1.00 103.06 ? 455  MET   A O   1 
ATOM   1333 C  CB  . MET   A 1 192 ? -17.665 -30.698 -4.046  1.00 103.25 ? 455  MET   A CB  1 
ATOM   1334 C  CG  . MET   A 1 192 ? -18.284 -30.456 -2.679  1.00 98.91  ? 455  MET   A CG  1 
ATOM   1335 S  SD  . MET   A 1 192 ? -20.044 -30.067 -2.743  1.00 98.41  ? 455  MET   A SD  1 
ATOM   1336 C  CE  . MET   A 1 192 ? -20.752 -31.704 -2.540  1.00 100.53 ? 455  MET   A CE  1 
ATOM   1337 N  N   . ALA   A 1 210 ? -12.300 -32.487 -9.929  0.34 96.24  ? 473  ALA   A N   1 
ATOM   1338 C  CA  . ALA   A 1 210 ? -12.897 -31.196 -9.511  0.34 94.69  ? 473  ALA   A CA  1 
ATOM   1339 C  C   . ALA   A 1 210 ? -14.271 -31.030 -10.170 0.34 93.53  ? 473  ALA   A C   1 
ATOM   1340 O  O   . ALA   A 1 210 ? -14.366 -31.225 -11.399 0.34 89.46  ? 473  ALA   A O   1 
ATOM   1341 C  CB  . ALA   A 1 210 ? -11.971 -30.059 -9.869  0.34 94.21  ? 473  ALA   A CB  1 
ATOM   1342 N  N   . ILE   A 1 211 ? -15.291 -30.691 -9.374  0.34 93.04  ? 474  ILE   A N   1 
ATOM   1343 C  CA  . ILE   A 1 211 ? -16.690 -30.461 -9.845  0.34 91.48  ? 474  ILE   A CA  1 
ATOM   1344 C  C   . ILE   A 1 211 ? -17.205 -29.142 -9.255  0.34 90.41  ? 474  ILE   A C   1 
ATOM   1345 O  O   . ILE   A 1 211 ? -17.138 -28.973 -8.021  0.34 89.98  ? 474  ILE   A O   1 
ATOM   1346 C  CB  . ILE   A 1 211 ? -17.607 -31.646 -9.483  0.34 91.74  ? 474  ILE   A CB  1 
ATOM   1347 C  CG1 . ILE   A 1 211 ? -17.041 -32.977 -9.987  0.34 93.77  ? 474  ILE   A CG1 1 
ATOM   1348 C  CG2 . ILE   A 1 211 ? -19.019 -31.406 -9.994  0.34 90.61  ? 474  ILE   A CG2 1 
ATOM   1349 C  CD1 . ILE   A 1 211 ? -15.695 -33.338 -9.398  0.34 94.21  ? 474  ILE   A CD1 1 
ATOM   1350 N  N   . TRP   A 1 212 ? -17.703 -28.258 -10.124 1.00 90.45  ? 475  TRP   A N   1 
ATOM   1351 C  CA  . TRP   A 1 212 ? -18.237 -26.926 -9.763  1.00 87.69  ? 475  TRP   A CA  1 
ATOM   1352 C  C   . TRP   A 1 212 ? -19.752 -26.979 -9.929  1.00 77.69  ? 475  TRP   A C   1 
ATOM   1353 O  O   . TRP   A 1 212 ? -20.221 -26.612 -11.014 1.00 95.84  ? 475  TRP   A O   1 
ATOM   1354 C  CB  . TRP   A 1 212 ? -17.614 -25.848 -10.663 1.00 89.98  ? 475  TRP   A CB  1 
ATOM   1355 C  CG  . TRP   A 1 212 ? -16.128 -25.917 -10.835 1.00 89.59  ? 475  TRP   A CG  1 
ATOM   1356 C  CD1 . TRP   A 1 212 ? -15.376 -27.012 -11.142 1.00 93.01  ? 475  TRP   A CD1 1 
ATOM   1357 C  CD2 . TRP   A 1 212 ? -15.209 -24.814 -10.765 1.00 87.45  ? 475  TRP   A CD2 1 
ATOM   1358 N  NE1 . TRP   A 1 212 ? -14.057 -26.675 -11.232 1.00 95.01  ? 475  TRP   A NE1 1 
ATOM   1359 C  CE2 . TRP   A 1 212 ? -13.922 -25.332 -11.011 1.00 90.10  ? 475  TRP   A CE2 1 
ATOM   1360 C  CE3 . TRP   A 1 212 ? -15.344 -23.441 -10.537 1.00 80.54  ? 475  TRP   A CE3 1 
ATOM   1361 C  CZ2 . TRP   A 1 212 ? -12.783 -24.530 -11.027 1.00 89.41  ? 475  TRP   A CZ2 1 
ATOM   1362 C  CZ3 . TRP   A 1 212 ? -14.219 -22.647 -10.559 1.00 82.41  ? 475  TRP   A CZ3 1 
ATOM   1363 C  CH2 . TRP   A 1 212 ? -12.956 -23.187 -10.805 1.00 84.62  ? 475  TRP   A CH2 1 
ATOM   1364 N  N   . TYR   A 1 213 ? -20.477 -27.438 -8.906  1.00 75.71  ? 476  TYR   A N   1 
ATOM   1365 C  CA  . TYR   A 1 213 ? -21.961 -27.377 -8.827  1.00 67.87  ? 476  TYR   A CA  1 
ATOM   1366 C  C   . TYR   A 1 213 ? -22.416 -25.903 -8.776  1.00 67.39  ? 476  TYR   A C   1 
ATOM   1367 O  O   . TYR   A 1 213 ? -21.769 -25.080 -8.119  1.00 64.77  ? 476  TYR   A O   1 
ATOM   1368 C  CB  . TYR   A 1 213 ? -22.471 -28.150 -7.603  1.00 74.56  ? 476  TYR   A CB  1 
ATOM   1369 C  CG  . TYR   A 1 213 ? -22.093 -29.612 -7.546  1.00 81.33  ? 476  TYR   A CG  1 
ATOM   1370 C  CD1 . TYR   A 1 213 ? -22.931 -30.590 -8.058  1.00 90.91  ? 476  TYR   A CD1 1 
ATOM   1371 C  CD2 . TYR   A 1 213 ? -20.906 -30.036 -6.965  1.00 88.82  ? 476  TYR   A CD2 1 
ATOM   1372 C  CE1 . TYR   A 1 213 ? -22.603 -31.937 -8.010  1.00 91.42  ? 476  TYR   A CE1 1 
ATOM   1373 C  CE2 . TYR   A 1 213 ? -20.562 -31.381 -6.903  1.00 87.96  ? 476  TYR   A CE2 1 
ATOM   1374 C  CZ  . TYR   A 1 213 ? -21.414 -32.337 -7.426  1.00 91.33  ? 476  TYR   A CZ  1 
ATOM   1375 O  OH  . TYR   A 1 213 ? -21.091 -33.663 -7.375  1.00 92.99  ? 476  TYR   A OH  1 
ATOM   1376 N  N   . MET   A 1 214 ? -23.542 -25.601 -9.434  0.25 64.61  ? 477  MET   A N   1 
ATOM   1377 C  CA  . MET   A 1 214 ? -24.226 -24.276 -9.418  0.25 62.38  ? 477  MET   A CA  1 
ATOM   1378 C  C   . MET   A 1 214 ? -25.712 -24.485 -9.105  0.25 58.75  ? 477  MET   A C   1 
ATOM   1379 O  O   . MET   A 1 214 ? -26.147 -25.649 -9.102  0.25 58.28  ? 477  MET   A O   1 
ATOM   1380 C  CB  . MET   A 1 214 ? -24.097 -23.574 -10.774 0.25 64.13  ? 477  MET   A CB  1 
ATOM   1381 C  CG  . MET   A 1 214 ? -23.231 -22.332 -10.756 0.25 64.99  ? 477  MET   A CG  1 
ATOM   1382 S  SD  . MET   A 1 214 ? -23.106 -21.603 -12.408 0.25 67.35  ? 477  MET   A SD  1 
ATOM   1383 C  CE  . MET   A 1 214 ? -22.094 -20.165 -12.072 0.25 65.99  ? 477  MET   A CE  1 
ATOM   1384 N  N   . TRP   A 1 215 ? -26.461 -23.403 -8.860  0.25 56.64  ? 478  TRP   A N   1 
ATOM   1385 C  CA  . TRP   A 1 215 ? -27.939 -23.457 -8.678  0.25 56.07  ? 478  TRP   A CA  1 
ATOM   1386 C  C   . TRP   A 1 215 ? -28.599 -23.669 -10.048 0.25 54.76  ? 478  TRP   A C   1 
ATOM   1387 O  O   . TRP   A 1 215 ? -28.091 -23.114 -11.042 0.25 54.29  ? 478  TRP   A O   1 
ATOM   1388 C  CB  . TRP   A 1 215 ? -28.468 -22.222 -7.933  0.25 55.13  ? 478  TRP   A CB  1 
ATOM   1389 C  CG  . TRP   A 1 215 ? -28.820 -21.036 -8.779  0.25 55.20  ? 478  TRP   A CG  1 
ATOM   1390 C  CD1 . TRP   A 1 215 ? -27.963 -20.224 -9.463  0.25 56.40  ? 478  TRP   A CD1 1 
ATOM   1391 C  CD2 . TRP   A 1 215 ? -30.136 -20.489 -8.989  0.25 55.39  ? 478  TRP   A CD2 1 
ATOM   1392 N  NE1 . TRP   A 1 215 ? -28.652 -19.229 -10.104 0.25 55.23  ? 478  TRP   A NE1 1 
ATOM   1393 C  CE2 . TRP   A 1 215 ? -29.987 -19.362 -9.828  0.25 55.61  ? 478  TRP   A CE2 1 
ATOM   1394 C  CE3 . TRP   A 1 215 ? -31.420 -20.845 -8.560  0.25 53.54  ? 478  TRP   A CE3 1 
ATOM   1395 C  CZ2 . TRP   A 1 215 ? -31.074 -18.591 -10.240 0.25 53.97  ? 478  TRP   A CZ2 1 
ATOM   1396 C  CZ3 . TRP   A 1 215 ? -32.493 -20.085 -8.972  0.25 54.54  ? 478  TRP   A CZ3 1 
ATOM   1397 C  CH2 . TRP   A 1 215 ? -32.320 -18.975 -9.800  0.25 55.03  ? 478  TRP   A CH2 1 
ATOM   1398 N  N   . LEU   A 1 216 ? -29.667 -24.472 -10.089 0.25 53.39  ? 479  LEU   A N   1 
ATOM   1399 C  CA  . LEU   A 1 216 ? -30.313 -24.975 -11.333 0.25 54.25  ? 479  LEU   A CA  1 
ATOM   1400 C  C   . LEU   A 1 216 ? -30.584 -23.812 -12.298 0.25 53.13  ? 479  LEU   A C   1 
ATOM   1401 O  O   . LEU   A 1 216 ? -30.415 -24.011 -13.515 0.25 52.04  ? 479  LEU   A O   1 
ATOM   1402 C  CB  . LEU   A 1 216 ? -31.609 -25.706 -10.965 0.25 55.11  ? 479  LEU   A CB  1 
ATOM   1403 C  CG  . LEU   A 1 216 ? -32.203 -26.588 -12.063 0.25 56.33  ? 479  LEU   A CG  1 
ATOM   1404 C  CD1 . LEU   A 1 216 ? -31.305 -27.784 -12.349 0.25 56.62  ? 479  LEU   A CD1 1 
ATOM   1405 C  CD2 . LEU   A 1 216 ? -33.601 -27.052 -11.684 0.25 57.16  ? 479  LEU   A CD2 1 
ATOM   1406 N  N   . GLY   A 1 217 ? -30.975 -22.647 -11.772 0.25 51.69  ? 480  GLY   A N   1 
ATOM   1407 C  CA  . GLY   A 1 217 ? -31.269 -21.430 -12.553 0.25 52.24  ? 480  GLY   A CA  1 
ATOM   1408 C  C   . GLY   A 1 217 ? -30.081 -20.977 -13.386 0.25 50.77  ? 480  GLY   A C   1 
ATOM   1409 O  O   . GLY   A 1 217 ? -30.291 -20.600 -14.553 0.25 48.61  ? 480  GLY   A O   1 
ATOM   1410 N  N   . ALA   A 1 218 ? -28.874 -21.010 -12.813 0.25 51.07  ? 481  ALA   A N   1 
ATOM   1411 C  CA  . ALA   A 1 218 ? -27.605 -20.681 -13.505 0.25 50.17  ? 481  ALA   A CA  1 
ATOM   1412 C  C   . ALA   A 1 218 ? -27.269 -21.787 -14.512 0.25 50.08  ? 481  ALA   A C   1 
ATOM   1413 O  O   . ALA   A 1 218 ? -26.753 -21.451 -15.594 0.25 50.03  ? 481  ALA   A O   1 
ATOM   1414 C  CB  . ALA   A 1 218 ? -26.492 -20.487 -12.506 0.25 49.47  ? 481  ALA   A CB  1 
ATOM   1415 N  N   . ARG   A 1 219 ? -27.552 -23.049 -14.162 0.25 50.70  ? 482  ARG   A N   1 
ATOM   1416 C  CA  . ARG   A 1 219 ? -27.331 -24.238 -15.033 0.25 52.13  ? 482  ARG   A CA  1 
ATOM   1417 C  C   . ARG   A 1 219 ? -28.264 -24.168 -16.244 0.25 51.44  ? 482  ARG   A C   1 
ATOM   1418 O  O   . ARG   A 1 219 ? -27.794 -24.477 -17.360 0.25 48.94  ? 482  ARG   A O   1 
ATOM   1419 C  CB  . ARG   A 1 219 ? -27.549 -25.556 -14.281 0.25 53.37  ? 482  ARG   A CB  1 
ATOM   1420 C  CG  . ARG   A 1 219 ? -26.266 -26.332 -14.026 0.25 58.05  ? 482  ARG   A CG  1 
ATOM   1421 C  CD  . ARG   A 1 219 ? -25.326 -25.572 -13.110 0.25 60.12  ? 482  ARG   A CD  1 
ATOM   1422 N  NE  . ARG   A 1 219 ? -24.023 -26.208 -12.942 0.25 61.43  ? 482  ARG   A NE  1 
ATOM   1423 C  CZ  . ARG   A 1 219 ? -22.928 -25.930 -13.647 0.25 61.87  ? 482  ARG   A CZ  1 
ATOM   1424 N  NH1 . ARG   A 1 219 ? -22.950 -25.025 -14.614 0.25 61.46  ? 482  ARG   A NH1 1 
ATOM   1425 N  NH2 . ARG   A 1 219 ? -21.803 -26.569 -13.379 0.25 64.27  ? 482  ARG   A NH2 1 
ATOM   1426 N  N   . PHE   A 1 220 ? -29.530 -23.793 -16.033 0.25 50.37  ? 483  PHE   A N   1 
ATOM   1427 C  CA  . PHE   A 1 220 ? -30.511 -23.590 -17.129 0.25 48.88  ? 483  PHE   A CA  1 
ATOM   1428 C  C   . PHE   A 1 220 ? -30.004 -22.483 -18.054 0.25 46.77  ? 483  PHE   A C   1 
ATOM   1429 O  O   . PHE   A 1 220 ? -29.993 -22.693 -19.281 0.25 47.55  ? 483  PHE   A O   1 
ATOM   1430 C  CB  . PHE   A 1 220 ? -31.905 -23.204 -16.631 0.25 49.21  ? 483  PHE   A CB  1 
ATOM   1431 C  CG  . PHE   A 1 220 ? -32.774 -22.694 -17.751 0.25 47.99  ? 483  PHE   A CG  1 
ATOM   1432 C  CD1 . PHE   A 1 220 ? -33.270 -23.565 -18.708 0.25 49.31  ? 483  PHE   A CD1 1 
ATOM   1433 C  CD2 . PHE   A 1 220 ? -33.023 -21.339 -17.900 0.25 48.55  ? 483  PHE   A CD2 1 
ATOM   1434 C  CE1 . PHE   A 1 220 ? -34.039 -23.098 -19.762 0.25 49.93  ? 483  PHE   A CE1 1 
ATOM   1435 C  CE2 . PHE   A 1 220 ? -33.792 -20.873 -18.955 0.25 49.73  ? 483  PHE   A CE2 1 
ATOM   1436 C  CZ  . PHE   A 1 220 ? -34.298 -21.753 -19.883 0.25 49.42  ? 483  PHE   A CZ  1 
ATOM   1437 N  N   . LEU   A 1 221 ? -29.631 -21.336 -17.477 1.00 43.68  ? 484  LEU   A N   1 
ATOM   1438 C  CA  . LEU   A 1 221 ? -29.148 -20.173 -18.256 1.00 48.44  ? 484  LEU   A CA  1 
ATOM   1439 C  C   . LEU   A 1 221 ? -27.882 -20.549 -19.049 1.00 50.84  ? 484  LEU   A C   1 
ATOM   1440 O  O   . LEU   A 1 221 ? -27.749 -20.097 -20.214 1.00 41.64  ? 484  LEU   A O   1 
ATOM   1441 C  CB  . LEU   A 1 221 ? -28.902 -19.008 -17.302 1.00 48.89  ? 484  LEU   A CB  1 
ATOM   1442 C  CG  . LEU   A 1 221 ? -30.157 -18.260 -16.843 1.00 54.67  ? 484  LEU   A CG  1 
ATOM   1443 C  CD1 . LEU   A 1 221 ? -29.775 -17.143 -15.896 1.00 59.51  ? 484  LEU   A CD1 1 
ATOM   1444 C  CD2 . LEU   A 1 221 ? -30.939 -17.687 -18.015 1.00 57.65  ? 484  LEU   A CD2 1 
ATOM   1445 N  N   . GLU   A 1 222 ? -26.988 -21.347 -18.454 1.00 46.03  ? 485  GLU   A N   1 
ATOM   1446 C  CA  . GLU   A 1 222 ? -25.832 -21.911 -19.194 1.00 46.09  ? 485  GLU   A CA  1 
ATOM   1447 C  C   . GLU   A 1 222 ? -26.373 -22.785 -20.351 1.00 42.55  ? 485  GLU   A C   1 
ATOM   1448 O  O   . GLU   A 1 222 ? -25.918 -22.592 -21.475 1.00 39.92  ? 485  GLU   A O   1 
ATOM   1449 C  CB  . GLU   A 1 222 ? -24.895 -22.655 -18.233 1.00 44.85  ? 485  GLU   A CB  1 
ATOM   1450 C  CG  . GLU   A 1 222 ? -23.715 -23.274 -18.944 1.00 47.72  ? 485  GLU   A CG  1 
ATOM   1451 C  CD  . GLU   A 1 222 ? -22.783 -24.073 -18.056 1.00 46.01  ? 485  GLU   A CD  1 
ATOM   1452 O  OE1 . GLU   A 1 222 ? -21.587 -23.732 -18.009 1.00 46.89  ? 485  GLU   A OE1 1 
ATOM   1453 O  OE2 . GLU   A 1 222 ? -23.255 -25.043 -17.451 1.00 45.26  ? 485  GLU   A OE2 1 
ATOM   1454 N  N   . PHE   A 1 223 ? -27.338 -23.677 -20.099 1.00 37.13  ? 486  PHE   A N   1 
ATOM   1455 C  CA  . PHE   A 1 223 ? -27.884 -24.648 -21.087 1.00 44.67  ? 486  PHE   A CA  1 
ATOM   1456 C  C   . PHE   A 1 223 ? -28.632 -23.920 -22.195 1.00 44.88  ? 486  PHE   A C   1 
ATOM   1457 O  O   . PHE   A 1 223 ? -28.447 -24.257 -23.369 1.00 40.73  ? 486  PHE   A O   1 
ATOM   1458 C  CB  . PHE   A 1 223 ? -28.775 -25.670 -20.404 1.00 46.39  ? 486  PHE   A CB  1 
ATOM   1459 C  CG  . PHE   A 1 223 ? -29.495 -26.606 -21.340 1.00 46.68  ? 486  PHE   A CG  1 
ATOM   1460 C  CD1 . PHE   A 1 223 ? -28.842 -27.687 -21.898 1.00 43.66  ? 486  PHE   A CD1 1 
ATOM   1461 C  CD2 . PHE   A 1 223 ? -30.837 -26.419 -21.625 1.00 46.98  ? 486  PHE   A CD2 1 
ATOM   1462 C  CE1 . PHE   A 1 223 ? -29.517 -28.563 -22.740 1.00 50.09  ? 486  PHE   A CE1 1 
ATOM   1463 C  CE2 . PHE   A 1 223 ? -31.514 -27.300 -22.447 1.00 46.40  ? 486  PHE   A CE2 1 
ATOM   1464 C  CZ  . PHE   A 1 223 ? -30.855 -28.377 -23.002 1.00 48.70  ? 486  PHE   A CZ  1 
ATOM   1465 N  N   . GLU   A 1 224 ? -29.326 -22.848 -21.845 1.00 48.96  ? 487  GLU   A N   1 
ATOM   1466 C  CA  . GLU   A 1 224 ? -30.126 -22.070 -22.809 1.00 47.13  ? 487  GLU   A CA  1 
ATOM   1467 C  C   . GLU   A 1 224 ? -29.174 -21.438 -23.843 1.00 49.86  ? 487  GLU   A C   1 
ATOM   1468 O  O   . GLU   A 1 224 ? -29.493 -21.440 -25.079 1.00 43.26  ? 487  GLU   A O   1 
ATOM   1469 C  CB  . GLU   A 1 224 ? -30.991 -21.050 -22.060 1.00 52.16  ? 487  GLU   A CB  1 
ATOM   1470 C  CG  . GLU   A 1 224 ? -31.405 -19.859 -22.918 1.00 56.72  ? 487  GLU   A CG  1 
ATOM   1471 C  CD  . GLU   A 1 224 ? -32.509 -18.991 -22.331 1.00 57.65  ? 487  GLU   A CD  1 
ATOM   1472 O  OE1 . GLU   A 1 224 ? -33.704 -19.339 -22.543 1.00 52.54  ? 487  GLU   A OE1 1 
ATOM   1473 O  OE2 . GLU   A 1 224 ? -32.168 -17.977 -21.672 1.00 52.36  ? 487  GLU   A OE2 1 
ATOM   1474 N  N   . ALA   A 1 225 ? -28.014 -20.975 -23.395 1.00 37.86  ? 488  ALA   A N   1 
ATOM   1475 C  CA  . ALA   A 1 225 ? -27.099 -20.181 -24.230 1.00 37.65  ? 488  ALA   A CA  1 
ATOM   1476 C  C   . ALA   A 1 225 ? -26.104 -21.059 -24.983 1.00 35.94  ? 488  ALA   A C   1 
ATOM   1477 O  O   . ALA   A 1 225 ? -25.719 -20.604 -26.099 1.00 40.38  ? 488  ALA   A O   1 
ATOM   1478 C  CB  . ALA   A 1 225 ? -26.372 -19.171 -23.391 1.00 43.47  ? 488  ALA   A CB  1 
ATOM   1479 N  N   . LEU   A 1 226 ? -25.673 -22.194 -24.414 1.00 38.28  ? 489  LEU   A N   1 
ATOM   1480 C  CA  . LEU   A 1 226 ? -24.488 -22.965 -24.917 1.00 35.25  ? 489  LEU   A CA  1 
ATOM   1481 C  C   . LEU   A 1 226 ? -24.791 -24.454 -25.061 1.00 35.46  ? 489  LEU   A C   1 
ATOM   1482 O  O   . LEU   A 1 226 ? -23.898 -25.185 -25.607 1.00 36.48  ? 489  LEU   A O   1 
ATOM   1483 C  CB  . LEU   A 1 226 ? -23.299 -22.729 -23.978 1.00 34.34  ? 489  LEU   A CB  1 
ATOM   1484 C  CG  . LEU   A 1 226 ? -22.777 -21.295 -23.960 1.00 39.07  ? 489  LEU   A CG  1 
ATOM   1485 C  CD1 . LEU   A 1 226 ? -21.522 -21.134 -23.116 1.00 43.25  ? 489  LEU   A CD1 1 
ATOM   1486 C  CD2 . LEU   A 1 226 ? -22.473 -20.831 -25.369 1.00 44.26  ? 489  LEU   A CD2 1 
ATOM   1487 N  N   . GLY   A 1 227 ? -25.992 -24.908 -24.678 1.00 29.92  ? 490  GLY   A N   1 
ATOM   1488 C  CA  . GLY   A 1 227 ? -26.430 -26.314 -24.831 1.00 32.20  ? 490  GLY   A CA  1 
ATOM   1489 C  C   . GLY   A 1 227 ? -26.409 -26.800 -26.258 1.00 29.71  ? 490  GLY   A C   1 
ATOM   1490 O  O   . GLY   A 1 227 ? -26.200 -28.030 -26.522 1.00 32.58  ? 490  GLY   A O   1 
ATOM   1491 N  N   . PHE   A 1 228 ? -26.608 -25.898 -27.193 1.00 31.63  ? 491  PHE   A N   1 
ATOM   1492 C  CA  . PHE   A 1 228 ? -26.611 -26.255 -28.641 1.00 34.23  ? 491  PHE   A CA  1 
ATOM   1493 C  C   . PHE   A 1 228 ? -25.334 -27.007 -29.061 1.00 30.30  ? 491  PHE   A C   1 
ATOM   1494 O  O   . PHE   A 1 228 ? -25.431 -27.887 -29.942 1.00 30.19  ? 491  PHE   A O   1 
ATOM   1495 C  CB  . PHE   A 1 228 ? -26.848 -25.030 -29.514 1.00 33.68  ? 491  PHE   A CB  1 
ATOM   1496 C  CG  . PHE   A 1 228 ? -25.704 -24.072 -29.651 1.00 30.02  ? 491  PHE   A CG  1 
ATOM   1497 C  CD1 . PHE   A 1 228 ? -25.522 -23.065 -28.721 1.00 34.93  ? 491  PHE   A CD1 1 
ATOM   1498 C  CD2 . PHE   A 1 228 ? -24.759 -24.232 -30.649 1.00 32.14  ? 491  PHE   A CD2 1 
ATOM   1499 C  CE1 . PHE   A 1 228 ? -24.464 -22.180 -28.825 1.00 33.61  ? 491  PHE   A CE1 1 
ATOM   1500 C  CE2 . PHE   A 1 228 ? -23.689 -23.351 -30.748 1.00 34.71  ? 491  PHE   A CE2 1 
ATOM   1501 C  CZ  . PHE   A 1 228 ? -23.531 -22.340 -29.825 1.00 34.77  ? 491  PHE   A CZ  1 
ATOM   1502 N  N   . LEU   A 1 229 ? -24.173 -26.666 -28.496 1.00 31.48  ? 492  LEU   A N   1 
ATOM   1503 C  CA  . LEU   A 1 229 ? -22.876 -27.345 -28.810 1.00 32.08  ? 492  LEU   A CA  1 
ATOM   1504 C  C   . LEU   A 1 229 ? -22.997 -28.859 -28.635 1.00 28.46  ? 492  LEU   A C   1 
ATOM   1505 O  O   . LEU   A 1 229 ? -22.603 -29.604 -29.535 1.00 30.67  ? 492  LEU   A O   1 
ATOM   1506 C  CB  . LEU   A 1 229 ? -21.785 -26.769 -27.902 1.00 34.16  ? 492  LEU   A CB  1 
ATOM   1507 C  CG  . LEU   A 1 229 ? -21.358 -25.358 -28.261 1.00 33.73  ? 492  LEU   A CG  1 
ATOM   1508 C  CD1 . LEU   A 1 229 ? -20.363 -24.849 -27.254 1.00 38.14  ? 492  LEU   A CD1 1 
ATOM   1509 C  CD2 . LEU   A 1 229 ? -20.778 -25.306 -29.681 1.00 34.73  ? 492  LEU   A CD2 1 
ATOM   1510 N  N   . ASN   A 1 230 ? -23.639 -29.299 -27.571 1.00 30.64  ? 493  ASN   A N   1 
ATOM   1511 C  CA  . ASN   A 1 230 ? -23.864 -30.745 -27.315 1.00 30.26  ? 493  ASN   A CA  1 
ATOM   1512 C  C   . ASN   A 1 230 ? -25.176 -31.233 -27.940 1.00 32.69  ? 493  ASN   A C   1 
ATOM   1513 O  O   . ASN   A 1 230 ? -25.176 -32.319 -28.613 1.00 30.34  ? 493  ASN   A O   1 
ATOM   1514 C  CB  . ASN   A 1 230 ? -23.905 -31.004 -25.812 1.00 35.37  ? 493  ASN   A CB  1 
ATOM   1515 C  CG  . ASN   A 1 230 ? -23.937 -32.486 -25.513 1.00 39.88  ? 493  ASN   A CG  1 
ATOM   1516 O  OD1 . ASN   A 1 230 ? -24.917 -33.039 -24.989 1.00 43.46  ? 493  ASN   A OD1 1 
ATOM   1517 N  ND2 . ASN   A 1 230 ? -22.877 -33.145 -25.914 1.00 40.20  ? 493  ASN   A ND2 1 
ATOM   1518 N  N   . GLU   A 1 231 ? -26.264 -30.474 -27.770 1.00 31.40  ? 494  GLU   A N   1 
ATOM   1519 C  CA  . GLU   A 1 231 ? -27.615 -30.897 -28.227 1.00 33.16  ? 494  GLU   A CA  1 
ATOM   1520 C  C   . GLU   A 1 231 ? -27.587 -31.094 -29.745 1.00 29.20  ? 494  GLU   A C   1 
ATOM   1521 O  O   . GLU   A 1 231 ? -28.222 -32.044 -30.215 1.00 29.59  ? 494  GLU   A O   1 
ATOM   1522 C  CB  . GLU   A 1 231 ? -28.672 -29.851 -27.846 1.00 37.46  ? 494  GLU   A CB  1 
ATOM   1523 C  CG  . GLU   A 1 231 ? -29.024 -29.818 -26.376 1.00 38.83  ? 494  GLU   A CG  1 
ATOM   1524 C  CD  . GLU   A 1 231 ? -29.566 -31.116 -25.800 1.00 48.22  ? 494  GLU   A CD  1 
ATOM   1525 O  OE1 . GLU   A 1 231 ? -30.435 -31.746 -26.424 1.00 49.31  ? 494  GLU   A OE1 1 
ATOM   1526 O  OE2 . GLU   A 1 231 ? -29.087 -31.500 -24.733 1.00 62.20  ? 494  GLU   A OE2 1 
ATOM   1527 N  N   . ASP   A 1 232 ? -26.812 -30.279 -30.477 1.00 32.01  ? 495  ASP   A N   1 
ATOM   1528 C  CA  . ASP   A 1 232 ? -26.790 -30.314 -31.965 1.00 29.82  ? 495  ASP   A CA  1 
ATOM   1529 C  C   . ASP   A 1 232 ? -25.449 -30.876 -32.468 1.00 32.06  ? 495  ASP   A C   1 
ATOM   1530 O  O   . ASP   A 1 232 ? -25.180 -30.811 -33.700 1.00 29.25  ? 495  ASP   A O   1 
ATOM   1531 C  CB  . ASP   A 1 232 ? -27.094 -28.921 -32.506 1.00 35.37  ? 495  ASP   A CB  1 
ATOM   1532 C  CG  . ASP   A 1 232 ? -28.453 -28.375 -32.085 1.00 32.01  ? 495  ASP   A CG  1 
ATOM   1533 O  OD1 . ASP   A 1 232 ? -29.292 -29.168 -31.672 1.00 37.79  ? 495  ASP   A OD1 1 
ATOM   1534 O  OD2 . ASP   A 1 232 ? -28.631 -27.164 -32.164 1.00 33.06  ? 495  ASP   A OD2 1 
ATOM   1535 N  N   . HIS   A 1 233 ? -24.672 -31.526 -31.596 1.00 33.35  ? 496  HIS   A N   1 
ATOM   1536 C  CA  . HIS   A 1 233 ? -23.557 -32.423 -32.005 1.00 30.37  ? 496  HIS   A CA  1 
ATOM   1537 C  C   . HIS   A 1 233 ? -22.480 -31.636 -32.770 1.00 25.03  ? 496  HIS   A C   1 
ATOM   1538 O  O   . HIS   A 1 233 ? -22.022 -32.086 -33.808 1.00 28.31  ? 496  HIS   A O   1 
ATOM   1539 C  CB  . HIS   A 1 233 ? -24.106 -33.585 -32.835 1.00 34.93  ? 496  HIS   A CB  1 
ATOM   1540 C  CG  . HIS   A 1 233 ? -25.251 -34.288 -32.206 1.00 43.05  ? 496  HIS   A CG  1 
ATOM   1541 N  ND1 . HIS   A 1 233 ? -25.134 -34.956 -30.998 1.00 49.27  ? 496  HIS   A ND1 1 
ATOM   1542 C  CD2 . HIS   A 1 233 ? -26.554 -34.373 -32.591 1.00 45.80  ? 496  HIS   A CD2 1 
ATOM   1543 C  CE1 . HIS   A 1 233 ? -26.322 -35.452 -30.672 1.00 48.05  ? 496  HIS   A CE1 1 
ATOM   1544 N  NE2 . HIS   A 1 233 ? -27.197 -35.129 -31.662 1.00 46.11  ? 496  HIS   A NE2 1 
ATOM   1545 N  N   . TRP   A 1 234 ? -22.054 -30.496 -32.265 1.00 25.45  ? 497  TRP   A N   1 
ATOM   1546 C  CA  . TRP   A 1 234 ? -21.009 -29.689 -32.960 1.00 27.08  ? 497  TRP   A CA  1 
ATOM   1547 C  C   . TRP   A 1 234 ? -19.661 -30.462 -33.039 1.00 29.73  ? 497  TRP   A C   1 
ATOM   1548 O  O   . TRP   A 1 234 ? -18.886 -30.270 -34.027 1.00 25.52  ? 497  TRP   A O   1 
ATOM   1549 C  CB  . TRP   A 1 234 ? -20.881 -28.325 -32.300 1.00 27.31  ? 497  TRP   A CB  1 
ATOM   1550 C  CG  . TRP   A 1 234 ? -21.914 -27.349 -32.786 1.00 34.49  ? 497  TRP   A CG  1 
ATOM   1551 C  CD1 . TRP   A 1 234 ? -23.266 -27.575 -32.909 1.00 32.38  ? 497  TRP   A CD1 1 
ATOM   1552 C  CD2 . TRP   A 1 234 ? -21.668 -26.042 -33.351 1.00 29.88  ? 497  TRP   A CD2 1 
ATOM   1553 N  NE1 . TRP   A 1 234 ? -23.872 -26.466 -33.452 1.00 30.95  ? 497  TRP   A NE1 1 
ATOM   1554 C  CE2 . TRP   A 1 234 ? -22.929 -25.515 -33.719 1.00 30.55  ? 497  TRP   A CE2 1 
ATOM   1555 C  CE3 . TRP   A 1 234 ? -20.524 -25.254 -33.544 1.00 32.05  ? 497  TRP   A CE3 1 
ATOM   1556 C  CZ2 . TRP   A 1 234 ? -23.074 -24.237 -34.251 1.00 31.44  ? 497  TRP   A CZ2 1 
ATOM   1557 C  CZ3 . TRP   A 1 234 ? -20.671 -23.991 -34.086 1.00 34.59  ? 497  TRP   A CZ3 1 
ATOM   1558 C  CH2 . TRP   A 1 234 ? -21.928 -23.505 -34.466 1.00 30.58  ? 497  TRP   A CH2 1 
ATOM   1559 N  N   . PHE   A 1 235 ? -19.383 -31.312 -32.044 0.28 28.65  ? 498  PHE   A N   1 
ATOM   1560 C  CA  . PHE   A 1 235 ? -18.090 -32.033 -31.886 0.28 28.67  ? 498  PHE   A CA  1 
ATOM   1561 C  C   . PHE   A 1 235 ? -18.235 -33.497 -32.316 0.28 29.14  ? 498  PHE   A C   1 
ATOM   1562 O  O   . PHE   A 1 235 ? -17.368 -34.317 -31.950 0.28 28.31  ? 498  PHE   A O   1 
ATOM   1563 C  CB  . PHE   A 1 235 ? -17.584 -31.851 -30.454 0.28 28.50  ? 498  PHE   A CB  1 
ATOM   1564 C  CG  . PHE   A 1 235 ? -17.274 -30.414 -30.124 0.28 28.87  ? 498  PHE   A CG  1 
ATOM   1565 C  CD1 . PHE   A 1 235 ? -16.177 -29.784 -30.689 0.28 29.47  ? 498  PHE   A CD1 1 
ATOM   1566 C  CD2 . PHE   A 1 235 ? -18.099 -29.679 -29.287 0.28 29.06  ? 498  PHE   A CD2 1 
ATOM   1567 C  CE1 . PHE   A 1 235 ? -15.899 -28.455 -30.412 0.28 30.42  ? 498  PHE   A CE1 1 
ATOM   1568 C  CE2 . PHE   A 1 235 ? -17.815 -28.352 -29.006 0.28 30.80  ? 498  PHE   A CE2 1 
ATOM   1569 C  CZ  . PHE   A 1 235 ? -16.719 -27.741 -29.573 0.28 30.66  ? 498  PHE   A CZ  1 
ATOM   1570 N  N   . SER   A 1 236 ? -19.281 -33.806 -33.090 0.28 28.76  ? 499  SER   A N   1 
ATOM   1571 C  CA  . SER   A 1 236 ? -19.445 -35.074 -33.848 0.28 28.39  ? 499  SER   A CA  1 
ATOM   1572 C  C   . SER   A 1 236 ? -18.239 -35.254 -34.774 0.28 28.13  ? 499  SER   A C   1 
ATOM   1573 O  O   . SER   A 1 236 ? -17.654 -34.223 -35.149 0.28 27.91  ? 499  SER   A O   1 
ATOM   1574 C  CB  . SER   A 1 236 ? -20.726 -35.037 -34.637 0.28 28.74  ? 499  SER   A CB  1 
ATOM   1575 O  OG  . SER   A 1 236 ? -20.818 -33.820 -35.370 0.28 27.72  ? 499  SER   A OG  1 
ATOM   1576 N  N   . ARG   A 1 237 ? -17.878 -36.489 -35.144 1.00 26.90  ? 500  ARG   A N   1 
ATOM   1577 C  CA  . ARG   A 1 237 ? -16.765 -36.693 -36.104 1.00 29.13  ? 500  ARG   A CA  1 
ATOM   1578 C  C   . ARG   A 1 237 ? -17.128 -36.102 -37.491 1.00 30.62  ? 500  ARG   A C   1 
ATOM   1579 O  O   . ARG   A 1 237 ? -16.284 -35.441 -38.105 1.00 28.78  ? 500  ARG   A O   1 
ATOM   1580 C  CB  . ARG   A 1 237 ? -16.283 -38.141 -36.153 1.00 31.07  ? 500  ARG   A CB  1 
ATOM   1581 C  CG  . ARG   A 1 237 ? -14.922 -38.278 -36.803 1.00 28.00  ? 500  ARG   A CG  1 
ATOM   1582 C  CD  . ARG   A 1 237 ? -14.222 -39.564 -36.395 1.00 27.84  ? 500  ARG   A CD  1 
ATOM   1583 N  NE  . ARG   A 1 237 ? -12.851 -39.477 -36.859 1.00 25.43  ? 500  ARG   A NE  1 
ATOM   1584 C  CZ  . ARG   A 1 237 ? -11.851 -38.857 -36.246 1.00 24.74  ? 500  ARG   A CZ  1 
ATOM   1585 N  NH1 . ARG   A 1 237 ? -12.029 -38.230 -35.102 1.00 23.57  ? 500  ARG   A NH1 1 
ATOM   1586 N  NH2 . ARG   A 1 237 ? -10.641 -38.898 -36.788 1.00 27.37  ? 500  ARG   A NH2 1 
ATOM   1587 N  N   . GLU   A 1 238 ? -18.366 -36.288 -37.959 0.28 30.47  ? 501  GLU   A N   1 
ATOM   1588 C  CA  . GLU   A 1 238 ? -18.804 -35.773 -39.290 0.28 30.37  ? 501  GLU   A CA  1 
ATOM   1589 C  C   . GLU   A 1 238 ? -18.598 -34.254 -39.333 0.28 29.16  ? 501  GLU   A C   1 
ATOM   1590 O  O   . GLU   A 1 238 ? -17.934 -33.778 -40.269 0.28 29.03  ? 501  GLU   A O   1 
ATOM   1591 C  CB  . GLU   A 1 238 ? -20.258 -36.131 -39.610 0.28 32.51  ? 501  GLU   A CB  1 
ATOM   1592 C  CG  . GLU   A 1 238 ? -20.756 -35.474 -40.889 0.28 33.76  ? 501  GLU   A CG  1 
ATOM   1593 C  CD  . GLU   A 1 238 ? -22.063 -36.020 -41.439 0.28 37.24  ? 501  GLU   A CD  1 
ATOM   1594 O  OE1 . GLU   A 1 238 ? -22.987 -35.209 -41.659 0.28 36.00  ? 501  GLU   A OE1 1 
ATOM   1595 O  OE2 . GLU   A 1 238 ? -22.154 -37.255 -41.656 0.28 39.32  ? 501  GLU   A OE2 1 
ATOM   1596 N  N   . ASN   A 1 239 ? -19.111 -33.520 -38.344 0.28 28.58  ? 502  ASN   A N   1 
ATOM   1597 C  CA  . ASN   A 1 239 ? -18.980 -32.040 -38.303 0.28 28.39  ? 502  ASN   A CA  1 
ATOM   1598 C  C   . ASN   A 1 239 ? -17.509 -31.650 -38.108 0.28 28.11  ? 502  ASN   A C   1 
ATOM   1599 O  O   . ASN   A 1 239 ? -16.970 -30.997 -39.004 0.28 26.60  ? 502  ASN   A O   1 
ATOM   1600 C  CB  . ASN   A 1 239 ? -19.835 -31.374 -37.224 0.28 28.38  ? 502  ASN   A CB  1 
ATOM   1601 C  CG  . ASN   A 1 239 ? -19.899 -29.875 -37.430 0.28 28.99  ? 502  ASN   A CG  1 
ATOM   1602 O  OD1 . ASN   A 1 239 ? -20.085 -29.418 -38.559 0.28 29.18  ? 502  ASN   A OD1 1 
ATOM   1603 N  ND2 . ASN   A 1 239 ? -19.722 -29.104 -36.366 0.28 28.25  ? 502  ASN   A ND2 1 
ATOM   1604 N  N   . SER   A 1 240 ? -16.881 -32.064 -36.999 1.00 27.44  ? 503  SER   A N   1 
ATOM   1605 C  CA  . SER   A 1 240 ? -15.603 -31.440 -36.497 1.00 27.83  ? 503  SER   A CA  1 
ATOM   1606 C  C   . SER   A 1 240 ? -14.316 -32.120 -37.027 1.00 23.86  ? 503  SER   A C   1 
ATOM   1607 O  O   . SER   A 1 240 ? -13.251 -31.579 -36.744 1.00 28.79  ? 503  SER   A O   1 
ATOM   1608 C  CB  . SER   A 1 240 ? -15.591 -31.450 -34.994 1.00 30.69  ? 503  SER   A CB  1 
ATOM   1609 O  OG  . SER   A 1 240 ? -15.555 -32.813 -34.499 1.00 27.06  ? 503  SER   A OG  1 
ATOM   1610 N  N   . LEU   A 1 241 ? -14.423 -33.300 -37.630 1.00 26.43  ? 504  LEU   A N   1 
ATOM   1611 C  CA  . LEU   A 1 241 ? -13.366 -34.169 -38.204 1.00 29.51  ? 504  LEU   A CA  1 
ATOM   1612 C  C   . LEU   A 1 241 ? -12.411 -34.791 -37.148 1.00 27.89  ? 504  LEU   A C   1 
ATOM   1613 O  O   . LEU   A 1 241 ? -11.991 -35.943 -37.347 1.00 28.93  ? 504  LEU   A O   1 
ATOM   1614 C  CB  . LEU   A 1 241 ? -12.591 -33.374 -39.265 1.00 32.04  ? 504  LEU   A CB  1 
ATOM   1615 C  CG  . LEU   A 1 241 ? -13.404 -32.747 -40.413 1.00 40.77  ? 504  LEU   A CG  1 
ATOM   1616 C  CD1 . LEU   A 1 241 ? -12.483 -32.181 -41.502 1.00 40.68  ? 504  LEU   A CD1 1 
ATOM   1617 C  CD2 . LEU   A 1 241 ? -14.353 -33.727 -41.055 1.00 43.03  ? 504  LEU   A CD2 1 
ATOM   1618 N  N   . SER   A 1 242 ? -12.063 -34.041 -36.095 0.28 26.73  ? 505  SER   A N   1 
ATOM   1619 C  CA  . SER   A 1 242 ? -11.196 -34.491 -34.971 0.28 26.45  ? 505  SER   A CA  1 
ATOM   1620 C  C   . SER   A 1 242 ? -12.038 -35.107 -33.850 0.28 25.65  ? 505  SER   A C   1 
ATOM   1621 O  O   . SER   A 1 242 ? -11.516 -35.980 -33.135 0.28 24.97  ? 505  SER   A O   1 
ATOM   1622 C  CB  . SER   A 1 242 ? -10.368 -33.351 -34.433 0.28 26.18  ? 505  SER   A CB  1 
ATOM   1623 O  OG  . SER   A 1 242 ? -9.752  -32.631 -35.486 0.28 27.72  ? 505  SER   A OG  1 
ATOM   1624 N  N   . GLY   A 1 243 ? -13.276 -34.632 -33.677 1.00 25.86  ? 506  GLY   A N   1 
ATOM   1625 C  CA  . GLY   A 1 243 ? -14.134 -35.000 -32.535 1.00 23.70  ? 506  GLY   A CA  1 
ATOM   1626 C  C   . GLY   A 1 243 ? -14.671 -36.420 -32.641 1.00 24.95  ? 506  GLY   A C   1 
ATOM   1627 O  O   . GLY   A 1 243 ? -14.549 -37.047 -33.694 1.00 26.86  ? 506  GLY   A O   1 
ATOM   1628 N  N   . VAL   A 1 244 ? -15.156 -36.910 -31.512 1.00 24.01  ? 507  VAL   A N   1 
ATOM   1629 C  CA  . VAL   A 1 244 ? -15.794 -38.239 -31.356 1.00 28.42  ? 507  VAL   A CA  1 
ATOM   1630 C  C   . VAL   A 1 244 ? -17.068 -38.107 -30.502 1.00 27.36  ? 507  VAL   A C   1 
ATOM   1631 O  O   . VAL   A 1 244 ? -17.540 -39.114 -29.990 1.00 26.76  ? 507  VAL   A O   1 
ATOM   1632 C  CB  . VAL   A 1 244 ? -14.812 -39.247 -30.735 1.00 27.29  ? 507  VAL   A CB  1 
ATOM   1633 C  CG1 . VAL   A 1 244 ? -13.624 -39.499 -31.636 1.00 28.35  ? 507  VAL   A CG1 1 
ATOM   1634 C  CG2 . VAL   A 1 244 ? -14.381 -38.834 -29.336 1.00 28.84  ? 507  VAL   A CG2 1 
ATOM   1635 N  N   . GLU   A 1 245 ? -17.654 -36.925 -30.391 1.00 27.78  ? 508  GLU   A N   1 
ATOM   1636 C  CA  . GLU   A 1 245 ? -18.891 -36.758 -29.562 1.00 34.26  ? 508  GLU   A CA  1 
ATOM   1637 C  C   . GLU   A 1 245 ? -20.006 -37.626 -30.145 1.00 27.63  ? 508  GLU   A C   1 
ATOM   1638 O  O   . GLU   A 1 245 ? -20.200 -37.671 -31.369 1.00 28.40  ? 508  GLU   A O   1 
ATOM   1639 C  CB  . GLU   A 1 245 ? -19.361 -35.311 -29.471 1.00 35.03  ? 508  GLU   A CB  1 
ATOM   1640 C  CG  . GLU   A 1 245 ? -20.453 -35.104 -28.408 1.00 41.59  ? 508  GLU   A CG  1 
ATOM   1641 C  CD  . GLU   A 1 245 ? -21.890 -35.371 -28.864 1.00 44.70  ? 508  GLU   A CD  1 
ATOM   1642 O  OE1 . GLU   A 1 245 ? -22.256 -34.947 -29.972 1.00 55.94  ? 508  GLU   A OE1 1 
ATOM   1643 O  OE2 . GLU   A 1 245 ? -22.645 -36.007 -28.103 1.00 56.76  ? 508  GLU   A OE2 1 
ATOM   1644 N  N   . GLY   A 1 246 ? -20.618 -38.444 -29.312 1.00 33.94  ? 509  GLY   A N   1 
ATOM   1645 C  CA  . GLY   A 1 246 ? -21.714 -39.348 -29.737 1.00 33.95  ? 509  GLY   A CA  1 
ATOM   1646 C  C   . GLY   A 1 246 ? -21.271 -40.659 -30.360 1.00 36.00  ? 509  GLY   A C   1 
ATOM   1647 O  O   . GLY   A 1 246 ? -22.139 -41.452 -30.753 1.00 34.47  ? 509  GLY   A O   1 
ATOM   1648 N  N   . GLU   A 1 247 ? -19.959 -40.882 -30.488 0.25 33.18  ? 510  GLU   A N   1 
ATOM   1649 C  CA  . GLU   A 1 247 ? -19.437 -42.055 -31.233 0.25 32.92  ? 510  GLU   A CA  1 
ATOM   1650 C  C   . GLU   A 1 247 ? -19.842 -43.322 -30.487 0.25 34.37  ? 510  GLU   A C   1 
ATOM   1651 O  O   . GLU   A 1 247 ? -20.673 -44.080 -31.028 0.25 36.36  ? 510  GLU   A O   1 
ATOM   1652 C  CB  . GLU   A 1 247 ? -17.925 -41.989 -31.457 0.25 30.44  ? 510  GLU   A CB  1 
ATOM   1653 C  CG  . GLU   A 1 247 ? -17.565 -41.311 -32.765 0.25 29.11  ? 510  GLU   A CG  1 
ATOM   1654 C  CD  . GLU   A 1 247 ? -18.264 -41.879 -33.990 0.25 27.92  ? 510  GLU   A CD  1 
ATOM   1655 O  OE1 . GLU   A 1 247 ? -18.636 -43.068 -33.970 0.25 28.07  ? 510  GLU   A OE1 1 
ATOM   1656 O  OE2 . GLU   A 1 247 ? -18.448 -41.128 -34.956 0.25 27.78  ? 510  GLU   A OE2 1 
ATOM   1657 N  N   . GLY   A 1 248 ? -19.328 -43.503 -29.273 1.00 33.94  ? 511  GLY   A N   1 
ATOM   1658 C  CA  . GLY   A 1 248 ? -19.525 -44.791 -28.561 1.00 36.90  ? 511  GLY   A CA  1 
ATOM   1659 C  C   . GLY   A 1 248 ? -18.250 -45.636 -28.591 1.00 34.51  ? 511  GLY   A C   1 
ATOM   1660 O  O   . GLY   A 1 248 ? -17.495 -45.623 -29.568 1.00 32.59  ? 511  GLY   A O   1 
ATOM   1661 N  N   A LEU   A 1 249 ? -18.014 -46.375 -27.508 0.12 34.80  ? 512  LEU   A N   1 
ATOM   1662 N  N   B LEU   A 1 249 ? -18.013 -46.370 -27.502 0.13 35.36  ? 512  LEU   A N   1 
ATOM   1663 C  CA  A LEU   A 1 249 ? -16.733 -47.081 -27.249 0.12 34.99  ? 512  LEU   A CA  1 
ATOM   1664 C  CA  B LEU   A 1 249 ? -16.739 -47.095 -27.245 0.13 35.88  ? 512  LEU   A CA  1 
ATOM   1665 C  C   A LEU   A 1 249 ? -16.469 -48.122 -28.340 0.12 34.42  ? 512  LEU   A C   1 
ATOM   1666 C  C   B LEU   A 1 249 ? -16.470 -48.083 -28.380 0.13 34.93  ? 512  LEU   A C   1 
ATOM   1667 O  O   A LEU   A 1 249 ? -15.288 -48.360 -28.644 0.12 35.50  ? 512  LEU   A O   1 
ATOM   1668 O  O   B LEU   A 1 249 ? -15.294 -48.243 -28.749 0.13 35.65  ? 512  LEU   A O   1 
ATOM   1669 C  CB  A LEU   A 1 249 ? -16.790 -47.729 -25.864 0.12 35.59  ? 512  LEU   A CB  1 
ATOM   1670 C  CB  B LEU   A 1 249 ? -16.820 -47.826 -25.900 0.13 37.31  ? 512  LEU   A CB  1 
ATOM   1671 C  CG  A LEU   A 1 249 ? -15.451 -48.220 -25.328 0.12 34.25  ? 512  LEU   A CG  1 
ATOM   1672 C  CG  B LEU   A 1 249 ? -15.670 -47.575 -24.929 0.13 36.62  ? 512  LEU   A CG  1 
ATOM   1673 C  CD1 A LEU   A 1 249 ? -14.453 -47.073 -25.218 0.12 33.22  ? 512  LEU   A CD1 1 
ATOM   1674 C  CD1 B LEU   A 1 249 ? -15.624 -48.672 -23.880 0.13 36.37  ? 512  LEU   A CD1 1 
ATOM   1675 C  CD2 A LEU   A 1 249 ? -15.633 -48.905 -23.986 0.12 34.19  ? 512  LEU   A CD2 1 
ATOM   1676 C  CD2 B LEU   A 1 249 ? -14.331 -47.465 -25.648 0.13 35.70  ? 512  LEU   A CD2 1 
ATOM   1677 N  N   . HIS   A 1 250 ? -17.532 -48.710 -28.898 0.25 34.28  ? 513  HIS   A N   1 
ATOM   1678 C  CA  . HIS   A 1 250 ? -17.494 -49.697 -30.012 0.25 33.62  ? 513  HIS   A CA  1 
ATOM   1679 C  C   . HIS   A 1 250 ? -16.943 -49.064 -31.300 0.25 32.09  ? 513  HIS   A C   1 
ATOM   1680 O  O   . HIS   A 1 250 ? -16.506 -49.830 -32.184 0.25 31.61  ? 513  HIS   A O   1 
ATOM   1681 C  CB  . HIS   A 1 250 ? -18.886 -50.316 -30.235 0.25 34.40  ? 513  HIS   A CB  1 
ATOM   1682 C  CG  . HIS   A 1 250 ? -19.953 -49.331 -30.582 0.25 34.15  ? 513  HIS   A CG  1 
ATOM   1683 N  ND1 . HIS   A 1 250 ? -20.421 -48.401 -29.674 0.25 33.89  ? 513  HIS   A ND1 1 
ATOM   1684 C  CD2 . HIS   A 1 250 ? -20.653 -49.136 -31.720 0.25 34.18  ? 513  HIS   A CD2 1 
ATOM   1685 C  CE1 . HIS   A 1 250 ? -21.355 -47.666 -30.244 0.25 33.96  ? 513  HIS   A CE1 1 
ATOM   1686 N  NE2 . HIS   A 1 250 ? -21.520 -48.101 -31.498 0.25 34.48  ? 513  HIS   A NE2 1 
ATOM   1687 N  N   . LYS   A 1 251 ? -16.980 -47.733 -31.414 0.25 31.04  ? 514  LYS   A N   1 
ATOM   1688 C  CA  . LYS   A 1 251 ? -16.564 -46.980 -32.630 0.25 30.90  ? 514  LYS   A CA  1 
ATOM   1689 C  C   . LYS   A 1 251 ? -15.101 -46.534 -32.518 0.25 29.00  ? 514  LYS   A C   1 
ATOM   1690 O  O   . LYS   A 1 251 ? -14.421 -46.510 -33.563 0.25 28.71  ? 514  LYS   A O   1 
ATOM   1691 C  CB  . LYS   A 1 251 ? -17.457 -45.751 -32.821 0.25 32.82  ? 514  LYS   A CB  1 
ATOM   1692 C  CG  . LYS   A 1 251 ? -18.955 -46.029 -32.770 0.25 35.13  ? 514  LYS   A CG  1 
ATOM   1693 C  CD  . LYS   A 1 251 ? -19.465 -46.802 -33.961 0.25 36.42  ? 514  LYS   A CD  1 
ATOM   1694 C  CE  . LYS   A 1 251 ? -19.640 -45.934 -35.189 0.25 37.52  ? 514  LYS   A CE  1 
ATOM   1695 N  NZ  . LYS   A 1 251 ? -20.812 -45.038 -35.052 0.25 37.67  ? 514  LYS   A NZ  1 
ATOM   1696 N  N   . LEU   A 1 252 ? -14.645 -46.186 -31.310 0.25 26.94  ? 515  LEU   A N   1 
ATOM   1697 C  CA  . LEU   A 1 252 ? -13.371 -45.450 -31.076 0.25 26.56  ? 515  LEU   A CA  1 
ATOM   1698 C  C   . LEU   A 1 252 ? -12.189 -46.228 -31.664 0.25 25.14  ? 515  LEU   A C   1 
ATOM   1699 O  O   . LEU   A 1 252 ? -11.306 -45.585 -32.261 0.25 24.96  ? 515  LEU   A O   1 
ATOM   1700 C  CB  . LEU   A 1 252 ? -13.176 -45.211 -29.578 0.25 26.29  ? 515  LEU   A CB  1 
ATOM   1701 C  CG  . LEU   A 1 252 ? -14.271 -44.410 -28.877 0.25 26.62  ? 515  LEU   A CG  1 
ATOM   1702 C  CD1 . LEU   A 1 252 ? -13.817 -44.009 -27.482 0.25 27.22  ? 515  LEU   A CD1 1 
ATOM   1703 C  CD2 . LEU   A 1 252 ? -14.669 -43.178 -29.674 0.25 27.10  ? 515  LEU   A CD2 1 
ATOM   1704 N  N   . GLY   A 1 253 ? -12.173 -47.556 -31.517 0.25 23.77  ? 516  GLY   A N   1 
ATOM   1705 C  CA  . GLY   A 1 253 ? -11.089 -48.396 -32.056 0.25 23.99  ? 516  GLY   A CA  1 
ATOM   1706 C  C   . GLY   A 1 253 ? -11.045 -48.325 -33.575 0.25 24.68  ? 516  GLY   A C   1 
ATOM   1707 O  O   . GLY   A 1 253 ? -9.928  -48.211 -34.132 0.25 24.79  ? 516  GLY   A O   1 
ATOM   1708 N  N   . TYR   A 1 254 ? -12.211 -48.372 -34.229 1.00 23.89  ? 517  TYR   A N   1 
ATOM   1709 C  CA  . TYR   A 1 254 ? -12.288 -48.254 -35.700 1.00 23.33  ? 517  TYR   A CA  1 
ATOM   1710 C  C   . TYR   A 1 254 ? -11.790 -46.859 -36.138 1.00 24.06  ? 517  TYR   A C   1 
ATOM   1711 O  O   . TYR   A 1 254 ? -11.069 -46.737 -37.156 1.00 24.70  ? 517  TYR   A O   1 
ATOM   1712 C  CB  . TYR   A 1 254 ? -13.690 -48.515 -36.219 1.00 23.44  ? 517  TYR   A CB  1 
ATOM   1713 C  CG  . TYR   A 1 254 ? -14.133 -49.944 -36.211 1.00 23.48  ? 517  TYR   A CG  1 
ATOM   1714 C  CD1 . TYR   A 1 254 ? -13.597 -50.857 -37.114 1.00 27.82  ? 517  TYR   A CD1 1 
ATOM   1715 C  CD2 . TYR   A 1 254 ? -15.109 -50.368 -35.329 1.00 23.88  ? 517  TYR   A CD2 1 
ATOM   1716 C  CE1 . TYR   A 1 254 ? -14.022 -52.180 -37.132 1.00 25.01  ? 517  TYR   A CE1 1 
ATOM   1717 C  CE2 . TYR   A 1 254 ? -15.590 -51.669 -35.380 1.00 24.99  ? 517  TYR   A CE2 1 
ATOM   1718 C  CZ  . TYR   A 1 254 ? -15.034 -52.583 -36.263 1.00 27.20  ? 517  TYR   A CZ  1 
ATOM   1719 O  OH  . TYR   A 1 254 ? -15.515 -53.874 -36.312 1.00 26.38  ? 517  TYR   A OH  1 
ATOM   1720 N  N   . ILE   A 1 255 ? -12.135 -45.842 -35.387 1.00 26.29  ? 518  ILE   A N   1 
ATOM   1721 C  CA  . ILE   A 1 255 ? -11.663 -44.470 -35.657 1.00 25.77  ? 518  ILE   A CA  1 
ATOM   1722 C  C   . ILE   A 1 255 ? -10.123 -44.393 -35.528 1.00 27.31  ? 518  ILE   A C   1 
ATOM   1723 O  O   . ILE   A 1 255 ? -9.464  -43.850 -36.447 1.00 27.52  ? 518  ILE   A O   1 
ATOM   1724 C  CB  . ILE   A 1 255 ? -12.417 -43.487 -34.768 1.00 27.23  ? 518  ILE   A CB  1 
ATOM   1725 C  CG1 . ILE   A 1 255 ? -13.895 -43.390 -35.192 1.00 26.70  ? 518  ILE   A CG1 1 
ATOM   1726 C  CG2 . ILE   A 1 255 ? -11.691 -42.138 -34.776 1.00 26.54  ? 518  ILE   A CG2 1 
ATOM   1727 C  CD1 . ILE   A 1 255 ? -14.783 -42.614 -34.187 1.00 27.97  ? 518  ILE   A CD1 1 
ATOM   1728 N  N   . LEU   A 1 256 ? -9.517  -44.941 -34.473 1.00 26.25  ? 519  LEU   A N   1 
ATOM   1729 C  CA  . LEU   A 1 256 ? -8.048  -44.914 -34.347 1.00 27.50  ? 519  LEU   A CA  1 
ATOM   1730 C  C   . LEU   A 1 256 ? -7.379  -45.689 -35.479 1.00 29.76  ? 519  LEU   A C   1 
ATOM   1731 O  O   . LEU   A 1 256 ? -6.343  -45.201 -35.940 1.00 29.60  ? 519  LEU   A O   1 
ATOM   1732 C  CB  . LEU   A 1 256 ? -7.587  -45.486 -33.016 1.00 27.93  ? 519  LEU   A CB  1 
ATOM   1733 C  CG  . LEU   A 1 256 ? -7.906  -44.682 -31.771 1.00 29.13  ? 519  LEU   A CG  1 
ATOM   1734 C  CD1 . LEU   A 1 256 ? -7.162  -45.357 -30.610 1.00 32.05  ? 519  LEU   A CD1 1 
ATOM   1735 C  CD2 . LEU   A 1 256 ? -7.470  -43.229 -31.936 1.00 32.49  ? 519  LEU   A CD2 1 
ATOM   1736 N  N   . ARG   A 1 257 ? -7.952  -46.820 -35.920 1.00 26.98  ? 520  ARG   A N   1 
ATOM   1737 C  CA  . ARG   A 1 257 ? -7.365  -47.616 -37.040 1.00 30.51  ? 520  ARG   A CA  1 
ATOM   1738 C  C   . ARG   A 1 257 ? -7.468  -46.803 -38.338 1.00 31.71  ? 520  ARG   A C   1 
ATOM   1739 O  O   . ARG   A 1 257 ? -6.521  -46.888 -39.155 1.00 31.58  ? 520  ARG   A O   1 
ATOM   1740 C  CB  . ARG   A 1 257 ? -8.020  -48.997 -37.143 1.00 28.80  ? 520  ARG   A CB  1 
ATOM   1741 C  CG  . ARG   A 1 257 ? -7.469  -49.860 -38.272 1.00 30.01  ? 520  ARG   A CG  1 
ATOM   1742 C  CD  . ARG   A 1 257 ? -8.218  -51.159 -38.375 1.00 27.22  ? 520  ARG   A CD  1 
ATOM   1743 N  NE  . ARG   A 1 257 ? -9.553  -51.016 -38.965 1.00 28.30  ? 520  ARG   A NE  1 
ATOM   1744 C  CZ  . ARG   A 1 257 ? -10.312 -52.048 -39.370 1.00 27.92  ? 520  ARG   A CZ  1 
ATOM   1745 N  NH1 . ARG   A 1 257 ? -9.929  -53.295 -39.182 1.00 30.70  ? 520  ARG   A NH1 1 
ATOM   1746 N  NH2 . ARG   A 1 257 ? -11.446 -51.830 -39.966 1.00 30.08  ? 520  ARG   A NH2 1 
ATOM   1747 N  N   . ASP   A 1 258 ? -8.523  -45.996 -38.516 1.00 29.15  ? 521  ASP   A N   1 
ATOM   1748 C  CA  . ASP   A 1 258 ? -8.653  -45.151 -39.749 1.00 31.48  ? 521  ASP   A CA  1 
ATOM   1749 C  C   . ASP   A 1 258 ? -7.567  -44.052 -39.723 1.00 30.16  ? 521  ASP   A C   1 
ATOM   1750 O  O   . ASP   A 1 258 ? -6.949  -43.827 -40.712 1.00 31.03  ? 521  ASP   A O   1 
ATOM   1751 C  CB  . ASP   A 1 258 ? -10.047 -44.546 -39.964 1.00 31.58  ? 521  ASP   A CB  1 
ATOM   1752 C  CG  . ASP   A 1 258 ? -11.066 -45.480 -40.613 1.00 33.46  ? 521  ASP   A CG  1 
ATOM   1753 O  OD1 . ASP   A 1 258 ? -10.681 -46.586 -41.045 1.00 33.43  ? 521  ASP   A OD1 1 
ATOM   1754 O  OD2 . ASP   A 1 258 ? -12.245 -45.132 -40.604 1.00 35.49  ? 521  ASP   A OD2 1 
ATOM   1755 N  N   . VAL   A 1 259 ? -7.307  -43.435 -38.596 1.00 28.91  ? 522  VAL   A N   1 
ATOM   1756 C  CA  . VAL   A 1 259 ? -6.191  -42.472 -38.427 1.00 30.14  ? 522  VAL   A CA  1 
ATOM   1757 C  C   . VAL   A 1 259 ? -4.859  -43.187 -38.744 1.00 33.19  ? 522  VAL   A C   1 
ATOM   1758 O  O   . VAL   A 1 259 ? -4.065  -42.606 -39.465 1.00 32.83  ? 522  VAL   A O   1 
ATOM   1759 C  CB  . VAL   A 1 259 ? -6.201  -41.928 -36.997 1.00 32.42  ? 522  VAL   A CB  1 
ATOM   1760 C  CG1 . VAL   A 1 259 ? -4.898  -41.169 -36.727 1.00 32.60  ? 522  VAL   A CG1 1 
ATOM   1761 C  CG2 . VAL   A 1 259 ? -7.431  -41.066 -36.748 1.00 30.24  ? 522  VAL   A CG2 1 
ATOM   1762 N  N   . SER   A 1 260 ? -4.662  -44.436 -38.317 1.00 30.44  ? 523  SER   A N   1 
ATOM   1763 C  CA  . SER   A 1 260 ? -3.393  -45.175 -38.511 1.00 28.86  ? 523  SER   A CA  1 
ATOM   1764 C  C   . SER   A 1 260 ? -3.122  -45.347 -40.009 1.00 30.73  ? 523  SER   A C   1 
ATOM   1765 O  O   . SER   A 1 260 ? -1.965  -45.457 -40.336 1.00 30.19  ? 523  SER   A O   1 
ATOM   1766 C  CB  . SER   A 1 260 ? -3.356  -46.506 -37.805 1.00 28.17  ? 523  SER   A CB  1 
ATOM   1767 O  OG  . SER   A 1 260 ? -4.018  -47.512 -38.557 1.00 32.15  ? 523  SER   A OG  1 
ATOM   1768 N  N   . LYS   A 1 261 ? -4.145  -45.291 -40.853 1.00 29.98  ? 524  LYS   A N   1 
ATOM   1769 C  CA  . LYS   A 1 261 ? -4.071  -45.582 -42.310 1.00 34.76  ? 524  LYS   A CA  1 
ATOM   1770 C  C   . LYS   A 1 261 ? -3.447  -44.404 -43.059 1.00 37.62  ? 524  LYS   A C   1 
ATOM   1771 O  O   . LYS   A 1 261 ? -3.010  -44.609 -44.193 1.00 38.66  ? 524  LYS   A O   1 
ATOM   1772 C  CB  . LYS   A 1 261 ? -5.461  -45.904 -42.861 1.00 39.60  ? 524  LYS   A CB  1 
ATOM   1773 C  CG  . LYS   A 1 261 ? -5.824  -47.355 -42.597 1.00 50.21  ? 524  LYS   A CG  1 
ATOM   1774 C  CD  . LYS   A 1 261 ? -7.240  -47.763 -42.904 1.00 57.53  ? 524  LYS   A CD  1 
ATOM   1775 C  CE  . LYS   A 1 261 ? -7.296  -49.272 -42.883 1.00 65.91  ? 524  LYS   A CE  1 
ATOM   1776 N  NZ  . LYS   A 1 261 ? -8.668  -49.772 -42.668 1.00 84.68  ? 524  LYS   A NZ  1 
ATOM   1777 N  N   . LYS   A 1 262 ? -3.457  -43.220 -42.457 1.00 35.80  ? 525  LYS   A N   1 
ATOM   1778 C  CA  . LYS   A 1 262 ? -2.837  -42.010 -43.037 1.00 39.05  ? 525  LYS   A CA  1 
ATOM   1779 C  C   . LYS   A 1 262 ? -1.324  -42.218 -43.123 1.00 44.72  ? 525  LYS   A C   1 
ATOM   1780 O  O   . LYS   A 1 262 ? -0.739  -42.822 -42.213 1.00 41.34  ? 525  LYS   A O   1 
ATOM   1781 C  CB  . LYS   A 1 262 ? -3.222  -40.800 -42.191 1.00 39.37  ? 525  LYS   A CB  1 
ATOM   1782 C  CG  . LYS   A 1 262 ? -4.726  -40.539 -42.202 1.00 41.43  ? 525  LYS   A CG  1 
ATOM   1783 C  CD  . LYS   A 1 262 ? -5.140  -39.106 -42.242 1.00 43.82  ? 525  LYS   A CD  1 
ATOM   1784 C  CE  . LYS   A 1 262 ? -6.602  -38.926 -42.574 1.00 47.23  ? 525  LYS   A CE  1 
ATOM   1785 N  NZ  . LYS   A 1 262 ? -6.755  -37.867 -43.607 1.00 53.40  ? 525  LYS   A NZ  1 
ATOM   1786 N  N   . GLU   A 1 263 ? -0.703  -41.730 -44.188 1.00 42.03  ? 526  GLU   A N   1 
ATOM   1787 C  CA  . GLU   A 1 263 ? 0.773   -41.596 -44.223 1.00 41.87  ? 526  GLU   A CA  1 
ATOM   1788 C  C   . GLU   A 1 263 ? 1.161   -40.588 -43.128 1.00 38.65  ? 526  GLU   A C   1 
ATOM   1789 O  O   . GLU   A 1 263 ? 0.474   -39.588 -42.964 1.00 37.84  ? 526  GLU   A O   1 
ATOM   1790 C  CB  . GLU   A 1 263 ? 1.251   -41.166 -45.618 1.00 50.62  ? 526  GLU   A CB  1 
ATOM   1791 C  CG  . GLU   A 1 263 ? 0.950   -42.181 -46.735 1.00 56.74  ? 526  GLU   A CG  1 
ATOM   1792 C  CD  . GLU   A 1 263 ? 1.648   -43.541 -46.635 1.00 70.40  ? 526  GLU   A CD  1 
ATOM   1793 O  OE1 . GLU   A 1 263 ? 2.841   -43.578 -46.231 1.00 70.86  ? 526  GLU   A OE1 1 
ATOM   1794 O  OE2 . GLU   A 1 263 ? 1.001   -44.578 -46.960 1.00 62.89  ? 526  GLU   A OE2 1 
ATOM   1795 N  N   . GLY   A 1 264 ? 2.197   -40.894 -42.369 1.00 32.19  ? 527  GLY   A N   1 
ATOM   1796 C  CA  . GLY   A 1 264 ? 2.813   -39.895 -41.497 1.00 35.74  ? 527  GLY   A CA  1 
ATOM   1797 C  C   . GLY   A 1 264 ? 3.664   -40.563 -40.459 1.00 37.28  ? 527  GLY   A C   1 
ATOM   1798 O  O   . GLY   A 1 264 ? 4.107   -41.695 -40.680 1.00 35.72  ? 527  GLY   A O   1 
ATOM   1799 N  N   . GLY   A 1 265 ? 3.884   -39.887 -39.343 1.00 36.35  ? 528  GLY   A N   1 
ATOM   1800 C  CA  . GLY   A 1 265 ? 4.807   -40.394 -38.322 1.00 36.94  ? 528  GLY   A CA  1 
ATOM   1801 C  C   . GLY   A 1 265 ? 4.115   -41.276 -37.296 1.00 40.43  ? 528  GLY   A C   1 
ATOM   1802 O  O   . GLY   A 1 265 ? 3.092   -41.898 -37.628 1.00 40.35  ? 528  GLY   A O   1 
ATOM   1803 N  N   . ALA   A 1 266 ? 4.720   -41.388 -36.120 1.00 33.90  ? 529  ALA   A N   1 
ATOM   1804 C  CA  . ALA   A 1 266 ? 4.164   -42.121 -34.964 1.00 32.80  ? 529  ALA   A CA  1 
ATOM   1805 C  C   . ALA   A 1 266 ? 2.771   -41.590 -34.615 1.00 32.40  ? 529  ALA   A C   1 
ATOM   1806 O  O   . ALA   A 1 266 ? 2.423   -40.472 -35.037 1.00 31.23  ? 529  ALA   A O   1 
ATOM   1807 C  CB  . ALA   A 1 266 ? 5.120   -42.022 -33.789 1.00 29.81  ? 529  ALA   A CB  1 
ATOM   1808 N  N   . MET   A 1 267 ? 2.013   -42.329 -33.792 1.00 29.92  ? 530  MET   A N   1 
ATOM   1809 C  CA  . MET   A 1 267 ? 0.784   -41.799 -33.148 1.00 30.23  ? 530  MET   A CA  1 
ATOM   1810 C  C   . MET   A 1 267 ? 1.161   -41.235 -31.780 1.00 26.75  ? 530  MET   A C   1 
ATOM   1811 O  O   . MET   A 1 267 ? 1.775   -41.931 -30.969 1.00 33.73  ? 530  MET   A O   1 
ATOM   1812 C  CB  . MET   A 1 267 ? -0.282  -42.913 -33.091 1.00 31.51  ? 530  MET   A CB  1 
ATOM   1813 C  CG  . MET   A 1 267 ? -0.721  -43.298 -34.484 1.00 34.40  ? 530  MET   A CG  1 
ATOM   1814 S  SD  . MET   A 1 267 ? -2.075  -44.537 -34.637 1.00 39.65  ? 530  MET   A SD  1 
ATOM   1815 C  CE  . MET   A 1 267 ? -3.458  -43.658 -33.936 1.00 39.93  ? 530  MET   A CE  1 
ATOM   1816 N  N   . TYR   A 1 268 ? 0.867   -39.972 -31.533 1.00 26.16  ? 531  TYR   A N   1 
ATOM   1817 C  CA  . TYR   A 1 268 ? 1.197   -39.289 -30.275 1.00 24.70  ? 531  TYR   A CA  1 
ATOM   1818 C  C   . TYR   A 1 268 ? -0.072  -39.203 -29.449 1.00 25.10  ? 531  TYR   A C   1 
ATOM   1819 O  O   . TYR   A 1 268 ? -1.192  -38.792 -29.975 1.00 27.67  ? 531  TYR   A O   1 
ATOM   1820 C  CB  . TYR   A 1 268 ? 1.825   -37.919 -30.596 1.00 24.38  ? 531  TYR   A CB  1 
ATOM   1821 C  CG  . TYR   A 1 268 ? 3.143   -38.056 -31.296 1.00 25.79  ? 531  TYR   A CG  1 
ATOM   1822 C  CD1 . TYR   A 1 268 ? 3.212   -38.243 -32.661 1.00 25.38  ? 531  TYR   A CD1 1 
ATOM   1823 C  CD2 . TYR   A 1 268 ? 4.329   -38.146 -30.580 1.00 29.14  ? 531  TYR   A CD2 1 
ATOM   1824 C  CE1 . TYR   A 1 268 ? 4.438   -38.410 -33.299 1.00 28.76  ? 531  TYR   A CE1 1 
ATOM   1825 C  CE2 . TYR   A 1 268 ? 5.547   -38.372 -31.198 1.00 26.75  ? 531  TYR   A CE2 1 
ATOM   1826 C  CZ  . TYR   A 1 268 ? 5.605   -38.514 -32.567 1.00 33.16  ? 531  TYR   A CZ  1 
ATOM   1827 O  OH  . TYR   A 1 268 ? 6.795   -38.718 -33.223 1.00 33.05  ? 531  TYR   A OH  1 
ATOM   1828 N  N   . ALA   A 1 269 ? 0.087   -39.417 -28.156 1.00 26.70  ? 532  ALA   A N   1 
ATOM   1829 C  CA  . ALA   A 1 269 ? -1.053  -39.381 -27.232 1.00 26.29  ? 532  ALA   A CA  1 
ATOM   1830 C  C   . ALA   A 1 269 ? -0.581  -38.775 -25.937 1.00 33.29  ? 532  ALA   A C   1 
ATOM   1831 O  O   . ALA   A 1 269 ? -0.545  -39.501 -24.949 1.00 31.83  ? 532  ALA   A O   1 
ATOM   1832 C  CB  . ALA   A 1 269 ? -1.637  -40.779 -27.056 1.00 28.57  ? 532  ALA   A CB  1 
ATOM   1833 N  N   . ASP   A 1 270 ? -0.234  -37.493 -25.945 1.00 28.32  ? 533  ASP   A N   1 
ATOM   1834 C  CA  . ASP   A 1 270 ? 0.367   -36.846 -24.758 1.00 30.08  ? 533  ASP   A CA  1 
ATOM   1835 C  C   . ASP   A 1 270 ? -0.787  -36.381 -23.875 1.00 32.73  ? 533  ASP   A C   1 
ATOM   1836 O  O   . ASP   A 1 270 ? -1.628  -35.651 -24.354 1.00 30.69  ? 533  ASP   A O   1 
ATOM   1837 C  CB  . ASP   A 1 270 ? 1.251   -35.655 -25.178 1.00 32.28  ? 533  ASP   A CB  1 
ATOM   1838 C  CG  . ASP   A 1 270 ? 2.539   -36.081 -25.874 1.00 37.24  ? 533  ASP   A CG  1 
ATOM   1839 O  OD1 . ASP   A 1 270 ? 2.902   -37.300 -25.785 1.00 35.19  ? 533  ASP   A OD1 1 
ATOM   1840 O  OD2 . ASP   A 1 270 ? 3.149   -35.232 -26.504 1.00 34.36  ? 533  ASP   A OD2 1 
ATOM   1841 N  N   . ASP   A 1 271 ? -0.773  -36.710 -22.610 1.00 32.86  ? 534  ASP   A N   1 
ATOM   1842 C  CA  . ASP   A 1 271 ? -1.775  -36.208 -21.646 1.00 37.35  ? 534  ASP   A CA  1 
ATOM   1843 C  C   . ASP   A 1 271 ? -1.260  -34.869 -21.113 1.00 35.54  ? 534  ASP   A C   1 
ATOM   1844 O  O   . ASP   A 1 271 ? -0.055  -34.692 -20.983 1.00 34.76  ? 534  ASP   A O   1 
ATOM   1845 C  CB  . ASP   A 1 271 ? -2.047  -37.243 -20.553 1.00 41.13  ? 534  ASP   A CB  1 
ATOM   1846 C  CG  . ASP   A 1 271 ? -3.037  -38.346 -20.927 1.00 51.07  ? 534  ASP   A CG  1 
ATOM   1847 O  OD1 . ASP   A 1 271 ? -3.931  -38.160 -21.851 1.00 48.77  ? 534  ASP   A OD1 1 
ATOM   1848 O  OD2 . ASP   A 1 271 ? -2.950  -39.392 -20.286 1.00 50.39  ? 534  ASP   A OD2 1 
ATOM   1849 N  N   . THR   A 1 272 ? -2.156  -33.921 -20.888 1.00 32.94  ? 535  THR   A N   1 
ATOM   1850 C  CA  . THR   A 1 272 ? -1.869  -32.637 -20.221 1.00 30.54  ? 535  THR   A CA  1 
ATOM   1851 C  C   . THR   A 1 272 ? -1.974  -32.854 -18.719 1.00 32.12  ? 535  THR   A C   1 
ATOM   1852 O  O   . THR   A 1 272 ? -2.864  -33.526 -18.292 1.00 34.49  ? 535  THR   A O   1 
ATOM   1853 C  CB  . THR   A 1 272 ? -2.784  -31.532 -20.745 1.00 33.90  ? 535  THR   A CB  1 
ATOM   1854 O  OG1 . THR   A 1 272 ? -2.545  -31.501 -22.140 1.00 33.92  ? 535  THR   A OG1 1 
ATOM   1855 C  CG2 . THR   A 1 272 ? -2.497  -30.165 -20.176 1.00 34.91  ? 535  THR   A CG2 1 
ATOM   1856 N  N   . ALA   A 1 273 ? -1.070  -32.268 -17.955 1.00 36.63  ? 536  ALA   A N   1 
ATOM   1857 C  CA  . ALA   A 1 273 ? -1.160  -32.211 -16.478 1.00 38.73  ? 536  ALA   A CA  1 
ATOM   1858 C  C   . ALA   A 1 273 ? -2.213  -31.151 -16.077 1.00 36.17  ? 536  ALA   A C   1 
ATOM   1859 O  O   . ALA   A 1 273 ? -2.001  -29.978 -16.367 1.00 38.77  ? 536  ALA   A O   1 
ATOM   1860 C  CB  . ALA   A 1 273 ? 0.235   -31.943 -15.937 1.00 40.03  ? 536  ALA   A CB  1 
ATOM   1861 N  N   . GLY   A 1 274 ? -3.361  -31.578 -15.544 1.00 40.00  ? 537  GLY   A N   1 
ATOM   1862 C  CA  . GLY   A 1 274 ? -4.422  -30.715 -14.982 1.00 39.46  ? 537  GLY   A CA  1 
ATOM   1863 C  C   . GLY   A 1 274 ? -5.007  -29.780 -16.031 1.00 39.65  ? 537  GLY   A C   1 
ATOM   1864 O  O   . GLY   A 1 274 ? -4.965  -28.526 -15.839 1.00 38.01  ? 537  GLY   A O   1 
ATOM   1865 N  N   . TRP   A 1 275 ? -5.533  -30.332 -17.129 1.00 33.14  ? 538  TRP   A N   1 
ATOM   1866 C  CA  . TRP   A 1 275 ? -5.998  -29.500 -18.274 1.00 32.68  ? 538  TRP   A CA  1 
ATOM   1867 C  C   . TRP   A 1 275 ? -6.866  -28.313 -17.803 1.00 29.73  ? 538  TRP   A C   1 
ATOM   1868 O  O   . TRP   A 1 275 ? -6.622  -27.184 -18.302 1.00 32.00  ? 538  TRP   A O   1 
ATOM   1869 C  CB  . TRP   A 1 275 ? -6.728  -30.343 -19.310 1.00 31.37  ? 538  TRP   A CB  1 
ATOM   1870 C  CG  . TRP   A 1 275 ? -7.326  -29.520 -20.417 1.00 31.48  ? 538  TRP   A CG  1 
ATOM   1871 C  CD1 . TRP   A 1 275 ? -8.533  -28.901 -20.369 1.00 32.50  ? 538  TRP   A CD1 1 
ATOM   1872 C  CD2 . TRP   A 1 275 ? -6.783  -29.230 -21.722 1.00 30.24  ? 538  TRP   A CD2 1 
ATOM   1873 N  NE1 . TRP   A 1 275 ? -8.801  -28.293 -21.559 1.00 33.33  ? 538  TRP   A NE1 1 
ATOM   1874 C  CE2 . TRP   A 1 275 ? -7.732  -28.441 -22.395 1.00 34.28  ? 538  TRP   A CE2 1 
ATOM   1875 C  CE3 . TRP   A 1 275 ? -5.614  -29.570 -22.402 1.00 31.81  ? 538  TRP   A CE3 1 
ATOM   1876 C  CZ2 . TRP   A 1 275 ? -7.540  -27.958 -23.688 1.00 33.57  ? 538  TRP   A CZ2 1 
ATOM   1877 C  CZ3 . TRP   A 1 275 ? -5.437  -29.120 -23.686 1.00 32.56  ? 538  TRP   A CZ3 1 
ATOM   1878 C  CH2 . TRP   A 1 275 ? -6.381  -28.315 -24.317 1.00 33.44  ? 538  TRP   A CH2 1 
ATOM   1879 N  N   . ASP   A 1 276 ? -7.854  -28.549 -16.959 1.00 32.53  ? 539  ASP   A N   1 
ATOM   1880 C  CA  . ASP   A 1 276 ? -8.874  -27.527 -16.547 1.00 37.77  ? 539  ASP   A CA  1 
ATOM   1881 C  C   . ASP   A 1 276 ? -8.165  -26.350 -15.855 1.00 40.28  ? 539  ASP   A C   1 
ATOM   1882 O  O   . ASP   A 1 276 ? -8.592  -25.167 -16.062 1.00 41.35  ? 539  ASP   A O   1 
ATOM   1883 C  CB  . ASP   A 1 276 ? -9.982  -28.147 -15.693 1.00 36.07  ? 539  ASP   A CB  1 
ATOM   1884 C  CG  . ASP   A 1 276 ? -11.043 -28.905 -16.499 1.00 40.03  ? 539  ASP   A CG  1 
ATOM   1885 O  OD1 . ASP   A 1 276 ? -10.933 -28.965 -17.735 1.00 44.37  ? 539  ASP   A OD1 1 
ATOM   1886 O  OD2 . ASP   A 1 276 ? -11.969 -29.454 -15.896 1.00 52.58  ? 539  ASP   A OD2 1 
ATOM   1887 N  N   . THR   A 1 277 ? -7.056  -26.624 -15.163 1.00 39.43  ? 540  THR   A N   1 
ATOM   1888 C  CA  . THR   A 1 277 ? -6.267  -25.599 -14.421 1.00 40.08  ? 540  THR   A CA  1 
ATOM   1889 C  C   . THR   A 1 277 ? -5.358  -24.782 -15.340 1.00 42.29  ? 540  THR   A C   1 
ATOM   1890 O  O   . THR   A 1 277 ? -4.897  -23.768 -14.901 1.00 44.94  ? 540  THR   A O   1 
ATOM   1891 C  CB  . THR   A 1 277 ? -5.463  -26.219 -13.258 1.00 41.00  ? 540  THR   A CB  1 
ATOM   1892 O  OG1 . THR   A 1 277 ? -4.492  -27.176 -13.678 1.00 44.84  ? 540  THR   A OG1 1 
ATOM   1893 C  CG2 . THR   A 1 277 ? -6.360  -26.928 -12.273 1.00 44.23  ? 540  THR   A CG2 1 
ATOM   1894 N  N   . ARG   A 1 278 ? -5.143  -25.242 -16.579 0.25 40.41  ? 541  ARG   A N   1 
ATOM   1895 C  CA  . ARG   A 1 278 ? -4.206  -24.640 -17.567 0.25 39.75  ? 541  ARG   A CA  1 
ATOM   1896 C  C   . ARG   A 1 278 ? -4.967  -23.791 -18.595 0.25 37.95  ? 541  ARG   A C   1 
ATOM   1897 O  O   . ARG   A 1 278 ? -4.312  -23.294 -19.525 0.25 37.33  ? 541  ARG   A O   1 
ATOM   1898 C  CB  . ARG   A 1 278 ? -3.436  -25.742 -18.303 0.25 40.49  ? 541  ARG   A CB  1 
ATOM   1899 C  CG  . ARG   A 1 278 ? -2.754  -26.751 -17.391 0.25 42.38  ? 541  ARG   A CG  1 
ATOM   1900 C  CD  . ARG   A 1 278 ? -1.458  -26.231 -16.810 0.25 43.93  ? 541  ARG   A CD  1 
ATOM   1901 N  NE  . ARG   A 1 278 ? -0.667  -27.302 -16.213 0.25 46.16  ? 541  ARG   A NE  1 
ATOM   1902 C  CZ  . ARG   A 1 278 ? 0.604   -27.186 -15.842 0.25 47.10  ? 541  ARG   A CZ  1 
ATOM   1903 N  NH1 . ARG   A 1 278 ? 1.251   -26.043 -16.013 0.25 48.64  ? 541  ARG   A NH1 1 
ATOM   1904 N  NH2 . ARG   A 1 278 ? 1.228   -28.218 -15.304 0.25 48.72  ? 541  ARG   A NH2 1 
ATOM   1905 N  N   . ILE   A 1 279 ? -6.290  -23.652 -18.454 1.00 36.50  ? 542  ILE   A N   1 
ATOM   1906 C  CA  . ILE   A 1 279 ? -7.111  -22.856 -19.396 1.00 36.79  ? 542  ILE   A CA  1 
ATOM   1907 C  C   . ILE   A 1 279 ? -6.838  -21.380 -19.068 1.00 34.90  ? 542  ILE   A C   1 
ATOM   1908 O  O   . ILE   A 1 279 ? -7.105  -20.951 -17.963 1.00 38.08  ? 542  ILE   A O   1 
ATOM   1909 C  CB  . ILE   A 1 279 ? -8.587  -23.280 -19.323 1.00 38.72  ? 542  ILE   A CB  1 
ATOM   1910 C  CG1 . ILE   A 1 279 ? -8.764  -24.658 -19.967 1.00 40.21  ? 542  ILE   A CG1 1 
ATOM   1911 C  CG2 . ILE   A 1 279 ? -9.515  -22.261 -19.982 1.00 35.88  ? 542  ILE   A CG2 1 
ATOM   1912 C  CD1 . ILE   A 1 279 ? -8.679  -24.609 -21.470 1.00 41.62  ? 542  ILE   A CD1 1 
ATOM   1913 N  N   . THR   A 1 280 ? -6.256  -20.654 -20.006 1.00 40.89  ? 543  THR   A N   1 
ATOM   1914 C  CA  . THR   A 1 280 ? -5.853  -19.243 -19.800 1.00 39.52  ? 543  THR   A CA  1 
ATOM   1915 C  C   . THR   A 1 280 ? -7.034  -18.313 -20.062 1.00 43.17  ? 543  THR   A C   1 
ATOM   1916 O  O   . THR   A 1 280 ? -8.038  -18.725 -20.748 1.00 36.18  ? 543  THR   A O   1 
ATOM   1917 C  CB  . THR   A 1 280 ? -4.690  -18.873 -20.711 1.00 35.60  ? 543  THR   A CB  1 
ATOM   1918 O  OG1 . THR   A 1 280 ? -5.079  -18.934 -22.087 1.00 37.54  ? 543  THR   A OG1 1 
ATOM   1919 C  CG2 . THR   A 1 280 ? -3.501  -19.764 -20.481 1.00 42.96  ? 543  THR   A CG2 1 
ATOM   1920 N  N   . LEU   A 1 281 ? -6.889  -17.038 -19.694 1.00 40.20  ? 544  LEU   A N   1 
ATOM   1921 C  CA  . LEU   A 1 281 ? -7.950  -16.059 -20.027 1.00 38.47  ? 544  LEU   A CA  1 
ATOM   1922 C  C   . LEU   A 1 281 ? -7.956  -15.894 -21.549 1.00 35.77  ? 544  LEU   A C   1 
ATOM   1923 O  O   . LEU   A 1 281 ? -9.005  -15.653 -22.097 1.00 39.98  ? 544  LEU   A O   1 
ATOM   1924 C  CB  . LEU   A 1 281 ? -7.685  -14.746 -19.266 1.00 53.77  ? 544  LEU   A CB  1 
ATOM   1925 C  CG  . LEU   A 1 281 ? -8.632  -13.587 -19.587 1.00 58.80  ? 544  LEU   A CG  1 
ATOM   1926 C  CD1 . LEU   A 1 281 ? -10.109 -13.965 -19.388 1.00 57.73  ? 544  LEU   A CD1 1 
ATOM   1927 C  CD2 . LEU   A 1 281 ? -8.268  -12.361 -18.751 1.00 65.34  ? 544  LEU   A CD2 1 
ATOM   1928 N  N   . GLU   A 1 282 ? -6.820  -16.082 -22.225 1.00 39.44  ? 545  GLU   A N   1 
ATOM   1929 C  CA  . GLU   A 1 282 ? -6.748  -15.998 -23.714 1.00 38.80  ? 545  GLU   A CA  1 
ATOM   1930 C  C   . GLU   A 1 282 ? -7.564  -17.128 -24.360 1.00 40.42  ? 545  GLU   A C   1 
ATOM   1931 O  O   . GLU   A 1 282 ? -8.260  -16.891 -25.401 1.00 35.90  ? 545  GLU   A O   1 
ATOM   1932 C  CB  . GLU   A 1 282 ? -5.287  -16.043 -24.125 1.00 48.34  ? 545  GLU   A CB  1 
ATOM   1933 C  CG  . GLU   A 1 282 ? -5.027  -15.410 -25.464 1.00 64.41  ? 545  GLU   A CG  1 
ATOM   1934 C  CD  . GLU   A 1 282 ? -5.318  -13.915 -25.571 1.00 63.37  ? 545  GLU   A CD  1 
ATOM   1935 O  OE1 . GLU   A 1 282 ? -5.306  -13.210 -24.535 1.00 63.63  ? 545  GLU   A OE1 1 
ATOM   1936 O  OE2 . GLU   A 1 282 ? -5.589  -13.482 -26.707 1.00 61.17  ? 545  GLU   A OE2 1 
ATOM   1937 N  N   . ASP   A 1 283 ? -7.509  -18.325 -23.763 0.25 39.00  ? 546  ASP   A N   1 
ATOM   1938 C  CA  . ASP   A 1 283 ? -8.313  -19.506 -24.181 0.25 38.33  ? 546  ASP   A CA  1 
ATOM   1939 C  C   . ASP   A 1 283 ? -9.807  -19.181 -24.034 0.25 37.63  ? 546  ASP   A C   1 
ATOM   1940 O  O   . ASP   A 1 283 ? -10.563 -19.459 -24.985 0.25 38.26  ? 546  ASP   A O   1 
ATOM   1941 C  CB  . ASP   A 1 283 ? -7.925  -20.760 -23.388 0.25 38.31  ? 546  ASP   A CB  1 
ATOM   1942 C  CG  . ASP   A 1 283 ? -6.524  -21.280 -23.679 0.25 38.73  ? 546  ASP   A CG  1 
ATOM   1943 O  OD1 . ASP   A 1 283 ? -6.115  -21.251 -24.861 0.25 38.11  ? 546  ASP   A OD1 1 
ATOM   1944 O  OD2 . ASP   A 1 283 ? -5.851  -21.712 -22.721 0.25 38.23  ? 546  ASP   A OD2 1 
ATOM   1945 N  N   . LEU   A 1 284 ? -10.217 -18.611 -22.894 1.00 36.66  ? 547  LEU   A N   1 
ATOM   1946 C  CA  . LEU   A 1 284 ? -11.650 -18.233 -22.654 1.00 37.70  ? 547  LEU   A CA  1 
ATOM   1947 C  C   . LEU   A 1 284 ? -12.180 -17.215 -23.678 1.00 37.61  ? 547  LEU   A C   1 
ATOM   1948 O  O   . LEU   A 1 284 ? -13.350 -17.329 -24.077 1.00 40.05  ? 547  LEU   A O   1 
ATOM   1949 C  CB  . LEU   A 1 284 ? -11.819 -17.737 -21.223 1.00 40.23  ? 547  LEU   A CB  1 
ATOM   1950 C  CG  . LEU   A 1 284 ? -11.510 -18.790 -20.170 1.00 38.50  ? 547  LEU   A CG  1 
ATOM   1951 C  CD1 . LEU   A 1 284 ? -11.399 -18.157 -18.803 1.00 49.26  ? 547  LEU   A CD1 1 
ATOM   1952 C  CD2 . LEU   A 1 284 ? -12.553 -19.905 -20.150 1.00 39.64  ? 547  LEU   A CD2 1 
ATOM   1953 N  N   . LYS   A 1 285 ? -11.322 -16.270 -24.083 0.25 37.60  ? 548  LYS   A N   1 
ATOM   1954 C  CA  . LYS   A 1 285 ? -11.599 -15.228 -25.111 0.25 37.97  ? 548  LYS   A CA  1 
ATOM   1955 C  C   . LYS   A 1 285 ? -11.780 -15.892 -26.482 0.25 38.02  ? 548  LYS   A C   1 
ATOM   1956 O  O   . LYS   A 1 285 ? -12.732 -15.511 -27.190 0.25 36.42  ? 548  LYS   A O   1 
ATOM   1957 C  CB  . LYS   A 1 285 ? -10.478 -14.181 -25.152 0.25 38.30  ? 548  LYS   A CB  1 
ATOM   1958 C  CG  . LYS   A 1 285 ? -10.460 -13.212 -23.977 0.25 38.75  ? 548  LYS   A CG  1 
ATOM   1959 C  CD  . LYS   A 1 285 ? -9.262  -12.275 -23.956 0.25 38.77  ? 548  LYS   A CD  1 
ATOM   1960 C  CE  . LYS   A 1 285 ? -9.262  -11.351 -22.754 0.25 39.33  ? 548  LYS   A CE  1 
ATOM   1961 N  NZ  . LYS   A 1 285 ? -7.961  -10.659 -22.583 0.25 40.42  ? 548  LYS   A NZ  1 
ATOM   1962 N  N   . ASN   A 1 286 ? -10.910 -16.846 -26.839 1.00 36.89  ? 549  ASN   A N   1 
ATOM   1963 C  CA  . ASN   A 1 286 ? -11.012 -17.551 -28.138 1.00 35.42  ? 549  ASN   A CA  1 
ATOM   1964 C  C   . ASN   A 1 286 ? -12.283 -18.417 -28.150 1.00 32.46  ? 549  ASN   A C   1 
ATOM   1965 O  O   . ASN   A 1 286 ? -12.969 -18.460 -29.188 1.00 32.10  ? 549  ASN   A O   1 
ATOM   1966 C  CB  . ASN   A 1 286 ? -9.726  -18.299 -28.429 1.00 37.44  ? 549  ASN   A CB  1 
ATOM   1967 C  CG  . ASN   A 1 286 ? -8.581  -17.334 -28.692 1.00 44.58  ? 549  ASN   A CG  1 
ATOM   1968 O  OD1 . ASN   A 1 286 ? -8.759  -16.305 -29.332 1.00 40.58  ? 549  ASN   A OD1 1 
ATOM   1969 N  ND2 . ASN   A 1 286 ? -7.392  -17.665 -28.248 1.00 42.70  ? 549  ASN   A ND2 1 
ATOM   1970 N  N   . GLU   A 1 287 ? -12.615 -19.063 -27.040 1.00 30.91  ? 550  GLU   A N   1 
ATOM   1971 C  CA  . GLU   A 1 287 ? -13.890 -19.838 -26.934 1.00 34.86  ? 550  GLU   A CA  1 
ATOM   1972 C  C   . GLU   A 1 287 ? -15.117 -18.904 -27.150 1.00 37.45  ? 550  GLU   A C   1 
ATOM   1973 O  O   . GLU   A 1 287 ? -16.063 -19.303 -27.895 1.00 35.22  ? 550  GLU   A O   1 
ATOM   1974 C  CB  . GLU   A 1 287 ? -13.891 -20.576 -25.605 1.00 34.12  ? 550  GLU   A CB  1 
ATOM   1975 C  CG  . GLU   A 1 287 ? -12.949 -21.771 -25.620 1.00 32.43  ? 550  GLU   A CG  1 
ATOM   1976 C  CD  . GLU   A 1 287 ? -12.575 -22.256 -24.233 1.00 39.76  ? 550  GLU   A CD  1 
ATOM   1977 O  OE1 . GLU   A 1 287 ? -13.257 -21.837 -23.261 1.00 41.61  ? 550  GLU   A OE1 1 
ATOM   1978 O  OE2 . GLU   A 1 287 ? -11.624 -23.087 -24.119 1.00 42.68  ? 550  GLU   A OE2 1 
ATOM   1979 N  N   A GLU   A 1 288 ? -15.084 -17.701 -26.560 0.12 38.26  ? 551  GLU   A N   1 
ATOM   1980 N  N   B GLU   A 1 288 ? -15.070 -17.697 -26.572 0.13 36.31  ? 551  GLU   A N   1 
ATOM   1981 C  CA  A GLU   A 1 288 ? -16.183 -16.692 -26.616 0.12 39.67  ? 551  GLU   A CA  1 
ATOM   1982 C  CA  B GLU   A 1 288 ? -16.164 -16.684 -26.609 0.13 36.45  ? 551  GLU   A CA  1 
ATOM   1983 C  C   A GLU   A 1 288 ? -16.522 -16.332 -28.069 0.12 38.90  ? 551  GLU   A C   1 
ATOM   1984 C  C   B GLU   A 1 288 ? -16.505 -16.293 -28.055 0.13 36.99  ? 551  GLU   A C   1 
ATOM   1985 O  O   A GLU   A 1 288 ? -17.697 -15.988 -28.323 0.12 40.55  ? 551  GLU   A O   1 
ATOM   1986 O  O   B GLU   A 1 288 ? -17.667 -15.898 -28.289 0.13 38.78  ? 551  GLU   A O   1 
ATOM   1987 C  CB  A GLU   A 1 288 ? -15.819 -15.425 -25.836 0.12 43.42  ? 551  GLU   A CB  1 
ATOM   1988 C  CB  B GLU   A 1 288 ? -15.779 -15.454 -25.782 0.13 37.56  ? 551  GLU   A CB  1 
ATOM   1989 C  CG  A GLU   A 1 288 ? -16.980 -14.451 -25.678 0.12 46.18  ? 551  GLU   A CG  1 
ATOM   1990 C  CG  B GLU   A 1 288 ? -16.951 -14.540 -25.448 0.13 37.92  ? 551  GLU   A CG  1 
ATOM   1991 C  CD  A GLU   A 1 288 ? -16.664 -13.173 -24.917 0.12 49.12  ? 551  GLU   A CD  1 
ATOM   1992 C  CD  B GLU   A 1 288 ? -17.196 -13.379 -26.402 0.13 38.49  ? 551  GLU   A CD  1 
ATOM   1993 O  OE1 A GLU   A 1 288 ? -15.510 -13.028 -24.459 0.12 51.78  ? 551  GLU   A OE1 1 
ATOM   1994 O  OE1 B GLU   A 1 288 ? -16.322 -13.114 -27.254 0.13 36.99  ? 551  GLU   A OE1 1 
ATOM   1995 O  OE2 A GLU   A 1 288 ? -17.577 -12.317 -24.787 0.12 51.51  ? 551  GLU   A OE2 1 
ATOM   1996 O  OE2 B GLU   A 1 288 ? -18.261 -12.729 -26.272 0.13 39.33  ? 551  GLU   A OE2 1 
ATOM   1997 N  N   . MET   A 1 289 ? -15.554 -16.416 -28.989 1.00 36.81  ? 552  MET   A N   1 
ATOM   1998 C  CA  . MET   A 1 289 ? -15.789 -16.088 -30.412 1.00 36.45  ? 552  MET   A CA  1 
ATOM   1999 C  C   . MET   A 1 289 ? -16.898 -16.945 -31.039 1.00 38.24  ? 552  MET   A C   1 
ATOM   2000 O  O   . MET   A 1 289 ? -17.366 -16.575 -32.155 1.00 39.11  ? 552  MET   A O   1 
ATOM   2001 C  CB  . MET   A 1 289 ? -14.501 -16.182 -31.245 1.00 36.13  ? 552  MET   A CB  1 
ATOM   2002 C  CG  . MET   A 1 289 ? -13.478 -15.120 -30.826 1.00 45.83  ? 552  MET   A CG  1 
ATOM   2003 S  SD  . MET   A 1 289 ? -12.224 -14.778 -32.111 1.00 52.93  ? 552  MET   A SD  1 
ATOM   2004 C  CE  . MET   A 1 289 ? -11.553 -16.417 -32.292 1.00 46.83  ? 552  MET   A CE  1 
ATOM   2005 N  N   . VAL   A 1 290 ? -17.364 -18.037 -30.412 1.00 37.40  ? 553  VAL   A N   1 
ATOM   2006 C  CA  . VAL   A 1 290 ? -18.595 -18.685 -30.948 1.00 35.73  ? 553  VAL   A CA  1 
ATOM   2007 C  C   . VAL   A 1 290 ? -19.752 -17.643 -31.028 1.00 34.06  ? 553  VAL   A C   1 
ATOM   2008 O  O   . VAL   A 1 290 ? -20.554 -17.755 -31.975 1.00 43.10  ? 553  VAL   A O   1 
ATOM   2009 C  CB  . VAL   A 1 290 ? -18.972 -19.957 -30.173 1.00 31.23  ? 553  VAL   A CB  1 
ATOM   2010 C  CG1 . VAL   A 1 290 ? -19.430 -19.682 -28.755 1.00 32.31  ? 553  VAL   A CG1 1 
ATOM   2011 C  CG2 . VAL   A 1 290 ? -20.043 -20.728 -30.904 1.00 32.48  ? 553  VAL   A CG2 1 
ATOM   2012 N  N   . THR   A 1 291 ? -19.842 -16.665 -30.118 1.00 34.35  ? 554  THR   A N   1 
ATOM   2013 C  CA  . THR   A 1 291 ? -20.916 -15.602 -30.101 1.00 36.69  ? 554  THR   A CA  1 
ATOM   2014 C  C   . THR   A 1 291 ? -20.920 -14.793 -31.410 1.00 39.16  ? 554  THR   A C   1 
ATOM   2015 O  O   . THR   A 1 291 ? -21.988 -14.262 -31.756 1.00 42.88  ? 554  THR   A O   1 
ATOM   2016 C  CB  . THR   A 1 291 ? -20.792 -14.654 -28.912 1.00 34.89  ? 554  THR   A CB  1 
ATOM   2017 O  OG1 . THR   A 1 291 ? -19.504 -14.029 -29.017 1.00 37.45  ? 554  THR   A OG1 1 
ATOM   2018 C  CG2 . THR   A 1 291 ? -20.969 -15.348 -27.578 1.00 33.16  ? 554  THR   A CG2 1 
ATOM   2019 N  N   . ASN   A 1 292 ? -19.799 -14.722 -32.133 1.00 40.03  ? 555  ASN   A N   1 
ATOM   2020 C  CA  . ASN   A 1 292 ? -19.697 -13.994 -33.426 1.00 43.72  ? 555  ASN   A CA  1 
ATOM   2021 C  C   . ASN   A 1 292 ? -20.649 -14.586 -34.465 1.00 49.50  ? 555  ASN   A C   1 
ATOM   2022 O  O   . ASN   A 1 292 ? -20.844 -13.923 -35.510 1.00 51.25  ? 555  ASN   A O   1 
ATOM   2023 C  CB  . ASN   A 1 292 ? -18.293 -13.993 -34.037 1.00 42.17  ? 555  ASN   A CB  1 
ATOM   2024 C  CG  . ASN   A 1 292 ? -17.313 -13.226 -33.185 1.00 42.89  ? 555  ASN   A CG  1 
ATOM   2025 O  OD1 . ASN   A 1 292 ? -17.712 -12.539 -32.246 1.00 48.90  ? 555  ASN   A OD1 1 
ATOM   2026 N  ND2 . ASN   A 1 292 ? -16.036 -13.391 -33.467 1.00 42.80  ? 555  ASN   A ND2 1 
ATOM   2027 N  N   . HIS   A 1 293 ? -21.145 -15.803 -34.235 1.00 40.12  ? 556  HIS   A N   1 
ATOM   2028 C  CA  . HIS   A 1 293 ? -21.965 -16.597 -35.180 1.00 46.83  ? 556  HIS   A CA  1 
ATOM   2029 C  C   . HIS   A 1 293 ? -23.438 -16.552 -34.760 1.00 42.01  ? 556  HIS   A C   1 
ATOM   2030 O  O   . HIS   A 1 293 ? -24.256 -17.286 -35.333 1.00 41.56  ? 556  HIS   A O   1 
ATOM   2031 C  CB  . HIS   A 1 293 ? -21.375 -18.023 -35.255 1.00 44.11  ? 556  HIS   A CB  1 
ATOM   2032 C  CG  . HIS   A 1 293 ? -19.994 -18.027 -35.827 1.00 50.20  ? 556  HIS   A CG  1 
ATOM   2033 N  ND1 . HIS   A 1 293 ? -19.761 -18.265 -37.166 1.00 51.65  ? 556  HIS   A ND1 1 
ATOM   2034 C  CD2 . HIS   A 1 293 ? -18.779 -17.802 -35.260 1.00 50.55  ? 556  HIS   A CD2 1 
ATOM   2035 C  CE1 . HIS   A 1 293 ? -18.462 -18.192 -37.403 1.00 47.25  ? 556  HIS   A CE1 1 
ATOM   2036 N  NE2 . HIS   A 1 293 ? -17.841 -17.886 -36.262 1.00 44.49  ? 556  HIS   A NE2 1 
ATOM   2037 N  N   . MET   A 1 294 ? -23.733 -15.820 -33.697 1.00 36.60  ? 557  MET   A N   1 
ATOM   2038 C  CA  . MET   A 1 294 ? -25.077 -15.779 -33.097 1.00 39.03  ? 557  MET   A CA  1 
ATOM   2039 C  C   . MET   A 1 294 ? -25.754 -14.439 -33.436 1.00 45.71  ? 557  MET   A C   1 
ATOM   2040 O  O   . MET   A 1 294 ? -25.106 -13.582 -34.007 1.00 39.24  ? 557  MET   A O   1 
ATOM   2041 C  CB  . MET   A 1 294 ? -24.961 -15.911 -31.588 1.00 38.65  ? 557  MET   A CB  1 
ATOM   2042 C  CG  . MET   A 1 294 ? -24.485 -17.279 -31.126 1.00 39.83  ? 557  MET   A CG  1 
ATOM   2043 S  SD  . MET   A 1 294 ? -24.263 -17.245 -29.356 1.00 37.19  ? 557  MET   A SD  1 
ATOM   2044 C  CE  . MET   A 1 294 ? -23.418 -18.810 -29.093 1.00 44.56  ? 557  MET   A CE  1 
ATOM   2045 N  N   . GLU   A 1 295 ? -27.005 -14.272 -33.023 1.00 49.63  ? 558  GLU   A N   1 
ATOM   2046 C  CA  . GLU   A 1 295 ? -27.768 -13.020 -33.236 1.00 52.99  ? 558  GLU   A CA  1 
ATOM   2047 C  C   . GLU   A 1 295 ? -28.848 -12.894 -32.170 1.00 49.09  ? 558  GLU   A C   1 
ATOM   2048 O  O   . GLU   A 1 295 ? -29.122 -13.895 -31.477 1.00 48.82  ? 558  GLU   A O   1 
ATOM   2049 C  CB  . GLU   A 1 295 ? -28.385 -13.042 -34.630 1.00 49.28  ? 558  GLU   A CB  1 
ATOM   2050 C  CG  . GLU   A 1 295 ? -29.430 -14.105 -34.837 1.00 50.89  ? 558  GLU   A CG  1 
ATOM   2051 C  CD  . GLU   A 1 295 ? -29.825 -14.296 -36.297 1.00 71.41  ? 558  GLU   A CD  1 
ATOM   2052 O  OE1 . GLU   A 1 295 ? -28.921 -14.266 -37.204 1.00 74.13  ? 558  GLU   A OE1 1 
ATOM   2053 O  OE2 . GLU   A 1 295 ? -31.040 -14.472 -36.538 1.00 71.24  ? 558  GLU   A OE2 1 
ATOM   2054 N  N   . GLY   A 1 296 ? -29.475 -11.715 -32.120 1.00 56.19  ? 559  GLY   A N   1 
ATOM   2055 C  CA  . GLY   A 1 296 ? -30.679 -11.452 -31.319 1.00 48.08  ? 559  GLY   A CA  1 
ATOM   2056 C  C   . GLY   A 1 296 ? -30.345 -11.537 -29.849 1.00 52.44  ? 559  GLY   A C   1 
ATOM   2057 O  O   . GLY   A 1 296 ? -29.153 -11.213 -29.506 1.00 51.07  ? 559  GLY   A O   1 
ATOM   2058 N  N   . GLU   A 1 297 ? -31.333 -12.022 -29.078 1.00 46.76  ? 560  GLU   A N   1 
ATOM   2059 C  CA  . GLU   A 1 297 ? -31.302 -12.384 -27.642 1.00 51.94  ? 560  GLU   A CA  1 
ATOM   2060 C  C   . GLU   A 1 297 ? -30.165 -13.393 -27.407 1.00 57.70  ? 560  GLU   A C   1 
ATOM   2061 O  O   . GLU   A 1 297 ? -29.359 -13.190 -26.493 1.00 53.75  ? 560  GLU   A O   1 
ATOM   2062 C  CB  . GLU   A 1 297 ? -32.625 -13.045 -27.243 1.00 57.07  ? 560  GLU   A CB  1 
ATOM   2063 C  CG  . GLU   A 1 297 ? -33.271 -12.433 -26.017 1.00 70.12  ? 560  GLU   A CG  1 
ATOM   2064 C  CD  . GLU   A 1 297 ? -34.658 -12.957 -25.691 1.00 79.19  ? 560  GLU   A CD  1 
ATOM   2065 O  OE1 . GLU   A 1 297 ? -34.790 -14.191 -25.527 1.00 80.80  ? 560  GLU   A OE1 1 
ATOM   2066 O  OE2 . GLU   A 1 297 ? -35.602 -12.130 -25.593 1.00 85.20  ? 560  GLU   A OE2 1 
ATOM   2067 N  N   . HIS   A 1 298 ? -30.119 -14.455 -28.205 1.00 50.93  ? 561  HIS   A N   1 
ATOM   2068 C  CA  . HIS   A 1 298 ? -29.148 -15.568 -28.038 1.00 48.55  ? 561  HIS   A CA  1 
ATOM   2069 C  C   . HIS   A 1 298 ? -27.741 -14.990 -27.931 1.00 43.70  ? 561  HIS   A C   1 
ATOM   2070 O  O   . HIS   A 1 298 ? -27.079 -15.320 -26.952 1.00 47.88  ? 561  HIS   A O   1 
ATOM   2071 C  CB  . HIS   A 1 298 ? -29.236 -16.608 -29.153 1.00 47.66  ? 561  HIS   A CB  1 
ATOM   2072 C  CG  . HIS   A 1 298 ? -28.321 -17.765 -28.906 1.00 47.19  ? 561  HIS   A CG  1 
ATOM   2073 N  ND1 . HIS   A 1 298 ? -27.855 -18.560 -29.921 1.00 42.63  ? 561  HIS   A ND1 1 
ATOM   2074 C  CD2 . HIS   A 1 298 ? -27.786 -18.240 -27.754 1.00 43.63  ? 561  HIS   A CD2 1 
ATOM   2075 C  CE1 . HIS   A 1 298 ? -27.071 -19.486 -29.405 1.00 47.81  ? 561  HIS   A CE1 1 
ATOM   2076 N  NE2 . HIS   A 1 298 ? -27.035 -19.326 -28.071 1.00 44.76  ? 561  HIS   A NE2 1 
ATOM   2077 N  N   . LYS   A 1 299 ? -27.345 -14.102 -28.845 1.00 45.35  ? 562  LYS   A N   1 
ATOM   2078 C  CA  . LYS   A 1 299 ? -25.996 -13.499 -28.830 1.00 46.71  ? 562  LYS   A CA  1 
ATOM   2079 C  C   . LYS   A 1 299 ? -25.764 -12.843 -27.470 1.00 55.55  ? 562  LYS   A C   1 
ATOM   2080 O  O   . LYS   A 1 299 ? -24.658 -13.024 -26.913 1.00 56.80  ? 562  LYS   A O   1 
ATOM   2081 C  CB  . LYS   A 1 299 ? -25.757 -12.530 -29.984 1.00 47.96  ? 562  LYS   A CB  1 
ATOM   2082 C  CG  . LYS   A 1 299 ? -24.401 -11.818 -29.950 1.00 46.76  ? 562  LYS   A CG  1 
ATOM   2083 C  CD  . LYS   A 1 299 ? -24.095 -11.150 -31.254 1.00 49.00  ? 562  LYS   A CD  1 
ATOM   2084 C  CE  . LYS   A 1 299 ? -22.934 -10.181 -31.265 1.00 50.33  ? 562  LYS   A CE  1 
ATOM   2085 N  NZ  . LYS   A 1 299 ? -21.861 -10.645 -32.173 1.00 54.81  ? 562  LYS   A NZ  1 
ATOM   2086 N  N   . LYS   A 1 300 ? -26.760 -12.132 -26.942 1.00 59.95  ? 563  LYS   A N   1 
ATOM   2087 C  CA  . LYS   A 1 300 ? -26.603 -11.355 -25.680 1.00 59.80  ? 563  LYS   A CA  1 
ATOM   2088 C  C   . LYS   A 1 300 ? -26.552 -12.328 -24.515 1.00 46.19  ? 563  LYS   A C   1 
ATOM   2089 O  O   . LYS   A 1 300 ? -25.712 -12.155 -23.654 1.00 47.87  ? 563  LYS   A O   1 
ATOM   2090 C  CB  . LYS   A 1 300 ? -27.756 -10.369 -25.425 1.00 68.18  ? 563  LYS   A CB  1 
ATOM   2091 C  CG  . LYS   A 1 300 ? -27.826 -9.191  -26.390 1.00 77.54  ? 563  LYS   A CG  1 
ATOM   2092 C  CD  . LYS   A 1 300 ? -26.581 -8.316  -26.427 1.00 78.76  ? 563  LYS   A CD  1 
ATOM   2093 C  CE  . LYS   A 1 300 ? -26.102 -8.003  -27.830 1.00 83.98  ? 563  LYS   A CE  1 
ATOM   2094 N  NZ  . LYS   A 1 300 ? -25.335 -6.732  -27.878 1.00 96.39  ? 563  LYS   A NZ  1 
ATOM   2095 N  N   . LEU   A 1 301 ? -27.434 -13.321 -24.509 1.00 45.67  ? 564  LEU   A N   1 
ATOM   2096 C  CA  . LEU   A 1 301 ? -27.465 -14.325 -23.427 1.00 47.30  ? 564  LEU   A CA  1 
ATOM   2097 C  C   . LEU   A 1 301 ? -26.119 -15.099 -23.365 1.00 51.85  ? 564  LEU   A C   1 
ATOM   2098 O  O   . LEU   A 1 301 ? -25.622 -15.311 -22.239 1.00 42.79  ? 564  LEU   A O   1 
ATOM   2099 C  CB  . LEU   A 1 301 ? -28.668 -15.231 -23.673 1.00 51.09  ? 564  LEU   A CB  1 
ATOM   2100 C  CG  . LEU   A 1 301 ? -30.037 -14.591 -23.391 1.00 49.05  ? 564  LEU   A CG  1 
ATOM   2101 C  CD1 . LEU   A 1 301 ? -31.136 -15.490 -23.903 1.00 50.74  ? 564  LEU   A CD1 1 
ATOM   2102 C  CD2 . LEU   A 1 301 ? -30.221 -14.325 -21.902 1.00 49.51  ? 564  LEU   A CD2 1 
ATOM   2103 N  N   . ALA   A 1 302 ? -25.544 -15.484 -24.516 1.00 45.51  ? 565  ALA   A N   1 
ATOM   2104 C  CA  . ALA   A 1 302 ? -24.273 -16.254 -24.632 1.00 48.06  ? 565  ALA   A CA  1 
ATOM   2105 C  C   . ALA   A 1 302 ? -23.115 -15.374 -24.167 1.00 46.25  ? 565  ALA   A C   1 
ATOM   2106 O  O   . ALA   A 1 302 ? -22.291 -15.872 -23.361 1.00 42.10  ? 565  ALA   A O   1 
ATOM   2107 C  CB  . ALA   A 1 302 ? -24.036 -16.733 -26.044 1.00 44.31  ? 565  ALA   A CB  1 
ATOM   2108 N  N   . GLU   A 1 303 ? -23.066 -14.122 -24.643 1.00 45.13  ? 566  GLU   A N   1 
ATOM   2109 C  CA  . GLU   A 1 303 ? -22.029 -13.115 -24.262 1.00 43.18  ? 566  GLU   A CA  1 
ATOM   2110 C  C   . GLU   A 1 303 ? -21.978 -12.922 -22.742 1.00 43.47  ? 566  GLU   A C   1 
ATOM   2111 O  O   . GLU   A 1 303 ? -20.862 -12.765 -22.217 1.00 46.51  ? 566  GLU   A O   1 
ATOM   2112 C  CB  . GLU   A 1 303 ? -22.279 -11.773 -24.937 1.00 52.81  ? 566  GLU   A CB  1 
ATOM   2113 C  CG  . GLU   A 1 303 ? -21.703 -11.719 -26.318 1.00 55.46  ? 566  GLU   A CG  1 
ATOM   2114 C  CD  . GLU   A 1 303 ? -22.132 -10.494 -27.095 1.00 65.13  ? 566  GLU   A CD  1 
ATOM   2115 O  OE1 . GLU   A 1 303 ? -22.627 -9.553  -26.454 1.00 73.27  ? 566  GLU   A OE1 1 
ATOM   2116 O  OE2 . GLU   A 1 303 ? -21.968 -10.497 -28.343 1.00 62.63  ? 566  GLU   A OE2 1 
ATOM   2117 N  N   . ALA   A 1 304 ? -23.120 -13.007 -22.062 1.00 42.71  ? 567  ALA   A N   1 
ATOM   2118 C  CA  . ALA   A 1 304 ? -23.250 -12.859 -20.595 1.00 46.54  ? 567  ALA   A CA  1 
ATOM   2119 C  C   . ALA   A 1 304 ? -22.723 -14.106 -19.888 1.00 43.62  ? 567  ALA   A C   1 
ATOM   2120 O  O   . ALA   A 1 304 ? -22.076 -13.932 -18.843 1.00 42.87  ? 567  ALA   A O   1 
ATOM   2121 C  CB  . ALA   A 1 304 ? -24.684 -12.586 -20.168 1.00 45.48  ? 567  ALA   A CB  1 
ATOM   2122 N  N   . ILE   A 1 305 ? -23.074 -15.306 -20.354 1.00 43.85  ? 568  ILE   A N   1 
ATOM   2123 C  CA  . ILE   A 1 305 ? -22.483 -16.535 -19.764 1.00 44.80  ? 568  ILE   A CA  1 
ATOM   2124 C  C   . ILE   A 1 305 ? -20.949 -16.365 -19.801 1.00 41.19  ? 568  ILE   A C   1 
ATOM   2125 O  O   . ILE   A 1 305 ? -20.321 -16.376 -18.725 1.00 38.51  ? 568  ILE   A O   1 
ATOM   2126 C  CB  . ILE   A 1 305 ? -22.983 -17.825 -20.445 1.00 47.31  ? 568  ILE   A CB  1 
ATOM   2127 C  CG1 . ILE   A 1 305 ? -24.492 -18.037 -20.262 1.00 46.48  ? 568  ILE   A CG1 1 
ATOM   2128 C  CG2 . ILE   A 1 305 ? -22.197 -19.033 -19.939 1.00 46.03  ? 568  ILE   A CG2 1 
ATOM   2129 C  CD1 . ILE   A 1 305 ? -24.953 -17.947 -18.817 1.00 45.41  ? 568  ILE   A CD1 1 
ATOM   2130 N  N   . PHE   A 1 306 ? -20.352 -16.113 -20.962 1.00 38.96  ? 569  PHE   A N   1 
ATOM   2131 C  CA  . PHE   A 1 306 ? -18.874 -16.053 -21.120 1.00 40.34  ? 569  PHE   A CA  1 
ATOM   2132 C  C   . PHE   A 1 306 ? -18.281 -14.945 -20.239 1.00 49.20  ? 569  PHE   A C   1 
ATOM   2133 O  O   . PHE   A 1 306 ? -17.322 -15.233 -19.514 1.00 48.32  ? 569  PHE   A O   1 
ATOM   2134 C  CB  . PHE   A 1 306 ? -18.468 -15.846 -22.579 1.00 43.48  ? 569  PHE   A CB  1 
ATOM   2135 C  CG  . PHE   A 1 306 ? -18.454 -17.104 -23.397 1.00 45.41  ? 569  PHE   A CG  1 
ATOM   2136 C  CD1 . PHE   A 1 306 ? -17.429 -18.025 -23.252 1.00 46.10  ? 569  PHE   A CD1 1 
ATOM   2137 C  CD2 . PHE   A 1 306 ? -19.431 -17.345 -24.344 1.00 43.87  ? 569  PHE   A CD2 1 
ATOM   2138 C  CE1 . PHE   A 1 306 ? -17.421 -19.183 -24.011 1.00 43.93  ? 569  PHE   A CE1 1 
ATOM   2139 C  CE2 . PHE   A 1 306 ? -19.411 -18.490 -25.117 1.00 43.61  ? 569  PHE   A CE2 1 
ATOM   2140 C  CZ  . PHE   A 1 306 ? -18.428 -19.425 -24.918 1.00 45.00  ? 569  PHE   A CZ  1 
ATOM   2141 N  N   . LYS   A 1 307 ? -18.817 -13.719 -20.304 1.00 49.06  ? 570  LYS   A N   1 
ATOM   2142 C  CA  . LYS   A 1 307 ? -18.312 -12.517 -19.571 1.00 53.15  ? 570  LYS   A CA  1 
ATOM   2143 C  C   . LYS   A 1 307 ? -18.494 -12.676 -18.053 1.00 45.01  ? 570  LYS   A C   1 
ATOM   2144 O  O   . LYS   A 1 307 ? -17.545 -12.416 -17.309 1.00 46.24  ? 570  LYS   A O   1 
ATOM   2145 C  CB  . LYS   A 1 307 ? -19.082 -11.241 -19.960 1.00 65.54  ? 570  LYS   A CB  1 
ATOM   2146 C  CG  . LYS   A 1 307 ? -18.260 -10.072 -20.480 1.00 77.01  ? 570  LYS   A CG  1 
ATOM   2147 C  CD  . LYS   A 1 307 ? -18.868 -8.721  -20.112 1.00 93.34  ? 570  LYS   A CD  1 
ATOM   2148 C  CE  . LYS   A 1 307 ? -18.045 -7.533  -20.567 1.00 96.63  ? 570  LYS   A CE  1 
ATOM   2149 N  NZ  . LYS   A 1 307 ? -18.004 -7.441  -22.046 1.00 105.12 ? 570  LYS   A NZ  1 
ATOM   2150 N  N   . LEU   A 1 308 ? -19.682 -13.058 -17.595 1.00 43.06  ? 571  LEU   A N   1 
ATOM   2151 C  CA  . LEU   A 1 308 ? -20.047 -12.913 -16.162 1.00 46.84  ? 571  LEU   A CA  1 
ATOM   2152 C  C   . LEU   A 1 308 ? -19.730 -14.165 -15.357 1.00 50.95  ? 571  LEU   A C   1 
ATOM   2153 O  O   . LEU   A 1 308 ? -19.493 -14.012 -14.140 1.00 55.10  ? 571  LEU   A O   1 
ATOM   2154 C  CB  . LEU   A 1 308 ? -21.533 -12.544 -16.070 1.00 53.11  ? 571  LEU   A CB  1 
ATOM   2155 C  CG  . LEU   A 1 308 ? -21.876 -11.255 -16.828 1.00 56.65  ? 571  LEU   A CG  1 
ATOM   2156 C  CD1 . LEU   A 1 308 ? -23.377 -11.000 -16.856 1.00 56.21  ? 571  LEU   A CD1 1 
ATOM   2157 C  CD2 . LEU   A 1 308 ? -21.127 -10.076 -16.235 1.00 55.00  ? 571  LEU   A CD2 1 
ATOM   2158 N  N   . THR   A 1 309 ? -19.782 -15.356 -15.957 1.00 46.29  ? 572  THR   A N   1 
ATOM   2159 C  CA  . THR   A 1 309 ? -19.676 -16.640 -15.216 1.00 47.41  ? 572  THR   A CA  1 
ATOM   2160 C  C   . THR   A 1 309 ? -18.405 -17.411 -15.597 1.00 46.98  ? 572  THR   A C   1 
ATOM   2161 O  O   . THR   A 1 309 ? -17.952 -18.163 -14.782 1.00 44.57  ? 572  THR   A O   1 
ATOM   2162 C  CB  . THR   A 1 309 ? -20.920 -17.504 -15.414 1.00 55.42  ? 572  THR   A CB  1 
ATOM   2163 O  OG1 . THR   A 1 309 ? -20.938 -17.869 -16.791 1.00 54.44  ? 572  THR   A OG1 1 
ATOM   2164 C  CG2 . THR   A 1 309 ? -22.201 -16.786 -15.063 1.00 63.01  ? 572  THR   A CG2 1 
ATOM   2165 N  N   . TYR   A 1 310 ? -17.827 -17.222 -16.774 1.00 49.17  ? 573  TYR   A N   1 
ATOM   2166 C  CA  . TYR   A 1 310 ? -16.648 -18.023 -17.209 1.00 52.59  ? 573  TYR   A CA  1 
ATOM   2167 C  C   . TYR   A 1 310 ? -15.388 -17.192 -17.020 1.00 52.56  ? 573  TYR   A C   1 
ATOM   2168 O  O   . TYR   A 1 310 ? -14.445 -17.751 -16.454 1.00 52.46  ? 573  TYR   A O   1 
ATOM   2169 C  CB  . TYR   A 1 310 ? -16.756 -18.483 -18.667 1.00 42.34  ? 573  TYR   A CB  1 
ATOM   2170 C  CG  . TYR   A 1 310 ? -17.754 -19.583 -18.934 1.00 39.80  ? 573  TYR   A CG  1 
ATOM   2171 C  CD1 . TYR   A 1 310 ? -18.583 -20.074 -17.951 1.00 36.85  ? 573  TYR   A CD1 1 
ATOM   2172 C  CD2 . TYR   A 1 310 ? -17.934 -20.056 -20.219 1.00 38.69  ? 573  TYR   A CD2 1 
ATOM   2173 C  CE1 . TYR   A 1 310 ? -19.510 -21.065 -18.219 1.00 39.82  ? 573  TYR   A CE1 1 
ATOM   2174 C  CE2 . TYR   A 1 310 ? -18.890 -21.006 -20.512 1.00 37.88  ? 573  TYR   A CE2 1 
ATOM   2175 C  CZ  . TYR   A 1 310 ? -19.654 -21.539 -19.507 1.00 37.36  ? 573  TYR   A CZ  1 
ATOM   2176 O  OH  . TYR   A 1 310 ? -20.609 -22.458 -19.806 1.00 42.95  ? 573  TYR   A OH  1 
ATOM   2177 N  N   . GLN   A 1 311 ? -15.384 -15.944 -17.518 1.00 43.76  ? 574  GLN   A N   1 
ATOM   2178 C  CA  . GLN   A 1 311 ? -14.216 -15.036 -17.479 1.00 44.11  ? 574  GLN   A CA  1 
ATOM   2179 C  C   . GLN   A 1 311 ? -14.120 -14.246 -16.150 1.00 46.13  ? 574  GLN   A C   1 
ATOM   2180 O  O   . GLN   A 1 311 ? -13.101 -13.590 -15.931 1.00 43.74  ? 574  GLN   A O   1 
ATOM   2181 C  CB  . GLN   A 1 311 ? -14.227 -14.104 -18.683 1.00 41.32  ? 574  GLN   A CB  1 
ATOM   2182 C  CG  . GLN   A 1 311 ? -14.080 -14.839 -19.995 1.00 44.77  ? 574  GLN   A CG  1 
ATOM   2183 C  CD  . GLN   A 1 311 ? -14.239 -13.917 -21.177 1.00 45.92  ? 574  GLN   A CD  1 
ATOM   2184 O  OE1 . GLN   A 1 311 ? -14.258 -12.708 -21.044 1.00 61.55  ? 574  GLN   A OE1 1 
ATOM   2185 N  NE2 . GLN   A 1 311 ? -14.273 -14.485 -22.362 1.00 53.05  ? 574  GLN   A NE2 1 
ATOM   2186 N  N   . ASN   A 1 312 ? -15.124 -14.339 -15.262 0.25 45.83  ? 575  ASN   A N   1 
ATOM   2187 C  CA  . ASN   A 1 312 ? -15.140 -13.644 -13.938 0.25 45.94  ? 575  ASN   A CA  1 
ATOM   2188 C  C   . ASN   A 1 312 ? -15.993 -14.437 -12.927 0.25 46.94  ? 575  ASN   A C   1 
ATOM   2189 O  O   . ASN   A 1 312 ? -17.182 -14.098 -12.776 0.25 49.23  ? 575  ASN   A O   1 
ATOM   2190 C  CB  . ASN   A 1 312 ? -15.656 -12.200 -14.059 0.25 44.03  ? 575  ASN   A CB  1 
ATOM   2191 C  CG  . ASN   A 1 312 ? -14.937 -11.357 -15.097 0.25 43.51  ? 575  ASN   A CG  1 
ATOM   2192 O  OD1 . ASN   A 1 312 ? -13.808 -10.919 -14.883 0.25 41.54  ? 575  ASN   A OD1 1 
ATOM   2193 N  ND2 . ASN   A 1 312 ? -15.586 -11.096 -16.221 0.25 41.91  ? 575  ASN   A ND2 1 
ATOM   2194 N  N   . LYS   A 1 313 ? -15.399 -15.403 -12.211 0.25 48.60  ? 576  LYS   A N   1 
ATOM   2195 C  CA  . LYS   A 1 313 ? -16.113 -16.448 -11.413 0.25 50.93  ? 576  LYS   A CA  1 
ATOM   2196 C  C   . LYS   A 1 313 ? -16.278 -16.037 -9.941  0.25 53.64  ? 576  LYS   A C   1 
ATOM   2197 O  O   . LYS   A 1 313 ? -15.635 -15.053 -9.531  0.25 55.57  ? 576  LYS   A O   1 
ATOM   2198 C  CB  . LYS   A 1 313 ? -15.344 -17.773 -11.431 0.25 51.57  ? 576  LYS   A CB  1 
ATOM   2199 C  CG  . LYS   A 1 313 ? -14.892 -18.261 -12.798 0.25 52.46  ? 576  LYS   A CG  1 
ATOM   2200 C  CD  . LYS   A 1 313 ? -14.097 -19.547 -12.726 0.25 52.53  ? 576  LYS   A CD  1 
ATOM   2201 C  CE  . LYS   A 1 313 ? -13.562 -19.984 -14.071 0.25 53.31  ? 576  LYS   A CE  1 
ATOM   2202 N  NZ  . LYS   A 1 313 ? -12.607 -18.998 -14.628 0.25 52.97  ? 576  LYS   A NZ  1 
ATOM   2203 N  N   . VAL   A 1 314 ? -17.112 -16.778 -9.189  1.00 53.38  ? 577  VAL   A N   1 
ATOM   2204 C  CA  . VAL   A 1 314 ? -17.319 -16.601 -7.735  1.00 55.19  ? 577  VAL   A CA  1 
ATOM   2205 C  C   . VAL   A 1 314 ? -17.589 -18.005 -7.213  1.00 52.68  ? 577  VAL   A C   1 
ATOM   2206 O  O   . VAL   A 1 314 ? -18.430 -18.717 -7.794  1.00 45.77  ? 577  VAL   A O   1 
ATOM   2207 C  CB  . VAL   A 1 314 ? -18.495 -15.642 -7.454  1.00 65.30  ? 577  VAL   A CB  1 
ATOM   2208 C  CG1 . VAL   A 1 314 ? -18.895 -15.652 -5.978  1.00 64.28  ? 577  VAL   A CG1 1 
ATOM   2209 C  CG2 . VAL   A 1 314 ? -18.201 -14.227 -7.955  1.00 55.40  ? 577  VAL   A CG2 1 
ATOM   2210 N  N   . VAL   A 1 315 ? -16.889 -18.410 -6.168  1.00 47.37  ? 578  VAL   A N   1 
ATOM   2211 C  CA  . VAL   A 1 315 ? -16.872 -19.840 -5.756  1.00 52.46  ? 578  VAL   A CA  1 
ATOM   2212 C  C   . VAL   A 1 315 ? -16.986 -19.939 -4.238  1.00 50.36  ? 578  VAL   A C   1 
ATOM   2213 O  O   . VAL   A 1 315 ? -16.411 -19.092 -3.563  1.00 52.42  ? 578  VAL   A O   1 
ATOM   2214 C  CB  . VAL   A 1 315 ? -15.575 -20.489 -6.263  1.00 53.11  ? 578  VAL   A CB  1 
ATOM   2215 C  CG1 . VAL   A 1 315 ? -15.592 -21.980 -5.999  1.00 57.23  ? 578  VAL   A CG1 1 
ATOM   2216 C  CG2 . VAL   A 1 315 ? -15.327 -20.169 -7.733  1.00 56.42  ? 578  VAL   A CG2 1 
ATOM   2217 N  N   . ARG   A 1 316 ? -17.638 -20.978 -3.739  1.00 57.28  ? 579  ARG   A N   1 
ATOM   2218 C  CA  . ARG   A 1 316 ? -17.765 -21.216 -2.285  1.00 66.50  ? 579  ARG   A CA  1 
ATOM   2219 C  C   . ARG   A 1 316 ? -17.148 -22.591 -1.971  1.00 70.88  ? 579  ARG   A C   1 
ATOM   2220 O  O   . ARG   A 1 316 ? -17.608 -23.611 -2.511  1.00 78.54  ? 579  ARG   A O   1 
ATOM   2221 C  CB  . ARG   A 1 316 ? -19.213 -20.989 -1.851  1.00 69.05  ? 579  ARG   A CB  1 
ATOM   2222 C  CG  . ARG   A 1 316 ? -20.247 -21.798 -2.609  1.00 76.36  ? 579  ARG   A CG  1 
ATOM   2223 C  CD  . ARG   A 1 316 ? -21.605 -21.648 -1.960  1.00 84.36  ? 579  ARG   A CD  1 
ATOM   2224 N  NE  . ARG   A 1 316 ? -22.100 -20.286 -2.037  1.00 87.44  ? 579  ARG   A NE  1 
ATOM   2225 C  CZ  . ARG   A 1 316 ? -23.332 -19.924 -1.723  1.00 91.66  ? 579  ARG   A CZ  1 
ATOM   2226 N  NH1 . ARG   A 1 316 ? -23.679 -18.653 -1.824  1.00 100.68 ? 579  ARG   A NH1 1 
ATOM   2227 N  NH2 . ARG   A 1 316 ? -24.212 -20.822 -1.309  1.00 91.19  ? 579  ARG   A NH2 1 
ATOM   2228 N  N   . VAL   A 1 317 ? -16.112 -22.599 -1.125  0.25 72.63  ? 580  VAL   A N   1 
ATOM   2229 C  CA  . VAL   A 1 317 ? -15.290 -23.799 -0.783  0.25 73.78  ? 580  VAL   A CA  1 
ATOM   2230 C  C   . VAL   A 1 317 ? -15.338 -24.006 0.736   0.25 76.69  ? 580  VAL   A C   1 
ATOM   2231 O  O   . VAL   A 1 317 ? -15.181 -23.009 1.467   0.25 73.94  ? 580  VAL   A O   1 
ATOM   2232 C  CB  . VAL   A 1 317 ? -13.839 -23.637 -1.276  0.25 73.10  ? 580  VAL   A CB  1 
ATOM   2233 C  CG1 . VAL   A 1 317 ? -13.058 -24.938 -1.172  0.25 72.92  ? 580  VAL   A CG1 1 
ATOM   2234 C  CG2 . VAL   A 1 317 ? -13.780 -23.091 -2.695  0.25 73.26  ? 580  VAL   A CG2 1 
ATOM   2235 N  N   . GLN   A 1 318 ? -15.540 -25.252 1.181   0.25 81.52  ? 581  GLN   A N   1 
ATOM   2236 C  CA  . GLN   A 1 318 ? -15.564 -25.638 2.619   0.25 84.86  ? 581  GLN   A CA  1 
ATOM   2237 C  C   . GLN   A 1 318 ? -14.133 -25.899 3.102   0.25 89.25  ? 581  GLN   A C   1 
ATOM   2238 O  O   . GLN   A 1 318 ? -13.463 -26.774 2.518   0.25 88.23  ? 581  GLN   A O   1 
ATOM   2239 C  CB  . GLN   A 1 318 ? -16.439 -26.872 2.853   0.25 83.70  ? 581  GLN   A CB  1 
ATOM   2240 C  CG  . GLN   A 1 318 ? -17.930 -26.562 2.898   0.25 83.86  ? 581  GLN   A CG  1 
ATOM   2241 C  CD  . GLN   A 1 318 ? -18.670 -27.402 3.911   0.25 84.54  ? 581  GLN   A CD  1 
ATOM   2242 O  OE1 . GLN   A 1 318 ? -18.339 -28.563 4.148   0.25 86.35  ? 581  GLN   A OE1 1 
ATOM   2243 N  NE2 . GLN   A 1 318 ? -19.686 -26.817 4.525   0.25 84.58  ? 581  GLN   A NE2 1 
ATOM   2244 N  N   . ARG   A 1 319 ? -13.703 -25.162 4.133   0.25 96.70  ? 582  ARG   A N   1 
ATOM   2245 C  CA  . ARG   A 1 319 ? -12.384 -25.298 4.810   0.25 101.10 ? 582  ARG   A CA  1 
ATOM   2246 C  C   . ARG   A 1 319 ? -12.619 -25.773 6.242   0.25 107.73 ? 582  ARG   A C   1 
ATOM   2247 O  O   . ARG   A 1 319 ? -13.259 -25.069 7.021   0.25 107.40 ? 582  ARG   A O   1 
ATOM   2248 C  CB  . ARG   A 1 319 ? -11.645 -23.957 4.781   0.25 99.07  ? 582  ARG   A CB  1 
ATOM   2249 C  CG  . ARG   A 1 319 ? -10.231 -24.004 5.343   0.25 97.65  ? 582  ARG   A CG  1 
ATOM   2250 C  CD  . ARG   A 1 319 ? -9.361  -22.898 4.776   0.25 96.97  ? 582  ARG   A CD  1 
ATOM   2251 N  NE  . ARG   A 1 319 ? -9.996  -21.590 4.886   0.25 96.57  ? 582  ARG   A NE  1 
ATOM   2252 C  CZ  . ARG   A 1 319 ? -9.863  -20.745 5.909   0.25 97.45  ? 582  ARG   A CZ  1 
ATOM   2253 N  NH1 . ARG   A 1 319 ? -9.104  -21.047 6.950   0.25 98.68  ? 582  ARG   A NH1 1 
ATOM   2254 N  NH2 . ARG   A 1 319 ? -10.498 -19.585 5.885   0.25 95.88  ? 582  ARG   A NH2 1 
ATOM   2255 N  N   . PRO   A 1 320 ? -12.132 -26.977 6.633   1.00 116.14 ? 583  PRO   A N   1 
ATOM   2256 C  CA  . PRO   A 1 320 ? -12.352 -27.494 7.998   1.00 120.40 ? 583  PRO   A CA  1 
ATOM   2257 C  C   . PRO   A 1 320 ? -11.996 -26.631 9.232   1.00 123.59 ? 583  PRO   A C   1 
ATOM   2258 O  O   . PRO   A 1 320 ? -12.645 -26.795 10.262  1.00 127.61 ? 583  PRO   A O   1 
ATOM   2259 C  CB  . PRO   A 1 320 ? -11.437 -28.740 8.054   1.00 118.01 ? 583  PRO   A CB  1 
ATOM   2260 C  CG  . PRO   A 1 320 ? -11.230 -29.170 6.614   1.00 112.75 ? 583  PRO   A CG  1 
ATOM   2261 C  CD  . PRO   A 1 320 ? -11.354 -27.906 5.788   1.00 116.78 ? 583  PRO   A CD  1 
ATOM   2262 N  N   . THR   A 1 321 ? -10.992 -25.752 9.116   1.00 118.70 ? 584  THR   A N   1 
ATOM   2263 C  CA  . THR   A 1 321 ? -10.485 -24.846 10.191  1.00 110.30 ? 584  THR   A CA  1 
ATOM   2264 C  C   . THR   A 1 321 ? -11.658 -24.145 10.896  1.00 90.79  ? 584  THR   A C   1 
ATOM   2265 O  O   . THR   A 1 321 ? -11.529 -23.889 12.108  1.00 87.51  ? 584  THR   A O   1 
ATOM   2266 C  CB  . THR   A 1 321 ? -9.517  -23.806 9.609   1.00 121.78 ? 584  THR   A CB  1 
ATOM   2267 O  OG1 . THR   A 1 321 ? -10.292 -22.878 8.848   1.00 126.64 ? 584  THR   A OG1 1 
ATOM   2268 C  CG2 . THR   A 1 321 ? -8.428  -24.396 8.733   1.00 119.75 ? 584  THR   A CG2 1 
ATOM   2269 N  N   . THR   A 1 325 ? -15.594 -25.880 10.701  0.25 107.09 ? 588  THR   A N   1 
ATOM   2270 C  CA  . THR   A 1 325 ? -15.953 -25.737 9.263   0.25 107.39 ? 588  THR   A CA  1 
ATOM   2271 C  C   . THR   A 1 325 ? -16.419 -24.301 8.990   0.25 106.62 ? 588  THR   A C   1 
ATOM   2272 O  O   . THR   A 1 325 ? -17.227 -23.780 9.784   0.25 105.98 ? 588  THR   A O   1 
ATOM   2273 C  CB  . THR   A 1 325 ? -17.017 -26.766 8.853   0.25 108.90 ? 588  THR   A CB  1 
ATOM   2274 O  OG1 . THR   A 1 325 ? -16.451 -28.067 9.013   0.25 109.35 ? 588  THR   A OG1 1 
ATOM   2275 C  CG2 . THR   A 1 325 ? -17.501 -26.599 7.429   0.25 110.30 ? 588  THR   A CG2 1 
ATOM   2276 N  N   . VAL   A 1 326 ? -15.916 -23.697 7.907   0.25 106.40 ? 589  VAL   A N   1 
ATOM   2277 C  CA  . VAL   A 1 326 ? -16.323 -22.350 7.399   0.25 105.43 ? 589  VAL   A CA  1 
ATOM   2278 C  C   . VAL   A 1 326 ? -16.477 -22.437 5.876   0.25 104.10 ? 589  VAL   A C   1 
ATOM   2279 O  O   . VAL   A 1 326 ? -16.070 -23.469 5.303   0.25 103.09 ? 589  VAL   A O   1 
ATOM   2280 C  CB  . VAL   A 1 326 ? -15.311 -21.259 7.803   0.25 104.58 ? 589  VAL   A CB  1 
ATOM   2281 C  CG1 . VAL   A 1 326 ? -15.264 -21.068 9.311   0.25 105.90 ? 589  VAL   A CG1 1 
ATOM   2282 C  CG2 . VAL   A 1 326 ? -13.917 -21.536 7.257   0.25 105.76 ? 589  VAL   A CG2 1 
ATOM   2283 N  N   . MET   A 1 327 ? -17.040 -21.396 5.251   1.00 103.99 ? 590  MET   A N   1 
ATOM   2284 C  CA  . MET   A 1 327 ? -17.221 -21.331 3.772   1.00 97.17  ? 590  MET   A CA  1 
ATOM   2285 C  C   . MET   A 1 327 ? -16.471 -20.098 3.271   1.00 80.75  ? 590  MET   A C   1 
ATOM   2286 O  O   . MET   A 1 327 ? -16.787 -19.009 3.755   1.00 72.02  ? 590  MET   A O   1 
ATOM   2287 C  CB  . MET   A 1 327 ? -18.700 -21.228 3.373   1.00 97.41  ? 590  MET   A CB  1 
ATOM   2288 C  CG  . MET   A 1 327 ? -18.968 -21.551 1.900   1.00 87.62  ? 590  MET   A CG  1 
ATOM   2289 S  SD  . MET   A 1 327 ? -18.885 -23.326 1.508   1.00 87.18  ? 590  MET   A SD  1 
ATOM   2290 C  CE  . MET   A 1 327 ? -20.475 -23.918 2.090   1.00 88.53  ? 590  MET   A CE  1 
ATOM   2291 N  N   . ASP   A 1 328 ? -15.515 -20.289 2.354   1.00 73.08  ? 591  ASP   A N   1 
ATOM   2292 C  CA  . ASP   A 1 328 ? -14.696 -19.216 1.732   1.00 74.94  ? 591  ASP   A CA  1 
ATOM   2293 C  C   . ASP   A 1 328 ? -15.320 -18.810 0.398   1.00 70.92  ? 591  ASP   A C   1 
ATOM   2294 O  O   . ASP   A 1 328 ? -15.763 -19.716 -0.347  1.00 64.03  ? 591  ASP   A O   1 
ATOM   2295 C  CB  . ASP   A 1 328 ? -13.249 -19.669 1.545   1.00 81.72  ? 591  ASP   A CB  1 
ATOM   2296 C  CG  . ASP   A 1 328 ? -12.555 -19.900 2.874   1.00 90.13  ? 591  ASP   A CG  1 
ATOM   2297 O  OD1 . ASP   A 1 328 ? -12.352 -18.903 3.600   1.00 96.20  ? 591  ASP   A OD1 1 
ATOM   2298 O  OD2 . ASP   A 1 328 ? -12.263 -21.075 3.198   1.00 84.13  ? 591  ASP   A OD2 1 
ATOM   2299 N  N   . ILE   A 1 329 ? -15.314 -17.504 0.131   1.00 60.14  ? 592  ILE   A N   1 
ATOM   2300 C  CA  . ILE   A 1 329 ? -15.928 -16.865 -1.061  1.00 60.60  ? 592  ILE   A CA  1 
ATOM   2301 C  C   . ILE   A 1 329 ? -14.785 -16.235 -1.831  1.00 69.68  ? 592  ILE   A C   1 
ATOM   2302 O  O   . ILE   A 1 329 ? -14.390 -15.077 -1.543  1.00 66.16  ? 592  ILE   A O   1 
ATOM   2303 C  CB  . ILE   A 1 329 ? -17.019 -15.833 -0.710  1.00 65.71  ? 592  ILE   A CB  1 
ATOM   2304 C  CG1 . ILE   A 1 329 ? -18.237 -16.494 -0.053  1.00 64.69  ? 592  ILE   A CG1 1 
ATOM   2305 C  CG2 . ILE   A 1 329 ? -17.404 -14.993 -1.930  1.00 64.25  ? 592  ILE   A CG2 1 
ATOM   2306 C  CD1 . ILE   A 1 329 ? -18.740 -17.746 -0.736  1.00 61.76  ? 592  ILE   A CD1 1 
ATOM   2307 N  N   . ILE   A 1 330 ? -14.319 -16.997 -2.809  1.00 73.06  ? 593  ILE   A N   1 
ATOM   2308 C  CA  . ILE   A 1 330 ? -13.096 -16.692 -3.590  1.00 74.31  ? 593  ILE   A CA  1 
ATOM   2309 C  C   . ILE   A 1 330 ? -13.513 -16.459 -5.040  1.00 65.20  ? 593  ILE   A C   1 
ATOM   2310 O  O   . ILE   A 1 330 ? -14.557 -16.976 -5.452  1.00 64.41  ? 593  ILE   A O   1 
ATOM   2311 C  CB  . ILE   A 1 330 ? -12.080 -17.835 -3.411  1.00 77.33  ? 593  ILE   A CB  1 
ATOM   2312 C  CG1 . ILE   A 1 330 ? -12.736 -19.220 -3.547  1.00 70.91  ? 593  ILE   A CG1 1 
ATOM   2313 C  CG2 . ILE   A 1 330 ? -11.374 -17.661 -2.070  1.00 75.33  ? 593  ILE   A CG2 1 
ATOM   2314 C  CD1 . ILE   A 1 330 ? -11.782 -20.362 -3.867  1.00 70.74  ? 593  ILE   A CD1 1 
ATOM   2315 N  N   . SER   A 1 331 ? -12.717 -15.681 -5.754  1.00 62.47  ? 594  SER   A N   1 
ATOM   2316 C  CA  . SER   A 1 331 ? -12.949 -15.332 -7.162  1.00 57.75  ? 594  SER   A CA  1 
ATOM   2317 C  C   . SER   A 1 331 ? -11.649 -15.514 -7.947  1.00 61.18  ? 594  SER   A C   1 
ATOM   2318 O  O   . SER   A 1 331 ? -10.561 -15.414 -7.352  1.00 61.38  ? 594  SER   A O   1 
ATOM   2319 C  CB  . SER   A 1 331 ? -13.474 -13.937 -7.252  1.00 57.66  ? 594  SER   A CB  1 
ATOM   2320 O  OG  . SER   A 1 331 ? -12.421 -12.994 -7.391  1.00 60.99  ? 594  SER   A OG  1 
ATOM   2321 N  N   . ARG   A 1 332 ? -11.777 -15.846 -9.234  0.25 56.88  ? 595  ARG   A N   1 
ATOM   2322 C  CA  . ARG   A 1 332 ? -10.660 -15.910 -10.212 0.25 54.18  ? 595  ARG   A CA  1 
ATOM   2323 C  C   . ARG   A 1 332 ? -11.251 -15.796 -11.616 0.25 52.31  ? 595  ARG   A C   1 
ATOM   2324 O  O   . ARG   A 1 332 ? -12.427 -16.177 -11.792 0.25 52.11  ? 595  ARG   A O   1 
ATOM   2325 C  CB  . ARG   A 1 332 ? -9.850  -17.203 -10.059 0.25 54.68  ? 595  ARG   A CB  1 
ATOM   2326 C  CG  . ARG   A 1 332 ? -10.371 -18.379 -10.874 0.25 54.47  ? 595  ARG   A CG  1 
ATOM   2327 C  CD  . ARG   A 1 332 ? -9.418  -19.560 -10.893 0.25 55.07  ? 595  ARG   A CD  1 
ATOM   2328 N  NE  . ARG   A 1 332 ? -8.090  -19.211 -11.391 0.25 53.73  ? 595  ARG   A NE  1 
ATOM   2329 C  CZ  . ARG   A 1 332 ? -7.013  -18.983 -10.637 0.25 53.70  ? 595  ARG   A CZ  1 
ATOM   2330 N  NH1 . ARG   A 1 332 ? -7.075  -19.054 -9.316  0.25 53.60  ? 595  ARG   A NH1 1 
ATOM   2331 N  NH2 . ARG   A 1 332 ? -5.864  -18.679 -11.215 0.25 53.71  ? 595  ARG   A NH2 1 
ATOM   2332 N  N   . ARG   A 1 333 ? -10.469 -15.290 -12.571 0.25 49.44  ? 596  ARG   A N   1 
ATOM   2333 C  CA  . ARG   A 1 333 ? -10.998 -15.057 -13.939 0.25 50.00  ? 596  ARG   A CA  1 
ATOM   2334 C  C   . ARG   A 1 333 ? -10.629 -16.212 -14.874 0.25 47.18  ? 596  ARG   A C   1 
ATOM   2335 O  O   . ARG   A 1 333 ? -11.426 -16.499 -15.783 0.25 43.62  ? 596  ARG   A O   1 
ATOM   2336 C  CB  . ARG   A 1 333 ? -10.425 -13.752 -14.495 0.25 50.78  ? 596  ARG   A CB  1 
ATOM   2337 C  CG  . ARG   A 1 333 ? -10.904 -12.498 -13.779 0.25 52.99  ? 596  ARG   A CG  1 
ATOM   2338 C  CD  . ARG   A 1 333 ? -10.641 -11.291 -14.657 0.25 53.98  ? 596  ARG   A CD  1 
ATOM   2339 N  NE  . ARG   A 1 333 ? -11.290 -11.456 -15.950 0.25 54.15  ? 596  ARG   A NE  1 
ATOM   2340 C  CZ  . ARG   A 1 333 ? -11.094 -10.668 -17.000 0.25 55.05  ? 596  ARG   A CZ  1 
ATOM   2341 N  NH1 . ARG   A 1 333 ? -10.250 -9.654  -16.918 0.25 55.24  ? 596  ARG   A NH1 1 
ATOM   2342 N  NH2 . ARG   A 1 333 ? -11.735 -10.903 -18.131 0.25 53.84  ? 596  ARG   A NH2 1 
ATOM   2343 N  N   . ASP   A 1 334 ? -9.472  -16.843 -14.664 0.25 46.43  ? 597  ASP   A N   1 
ATOM   2344 C  CA  . ASP   A 1 334 ? -9.004  -17.896 -15.605 0.25 47.22  ? 597  ASP   A CA  1 
ATOM   2345 C  C   . ASP   A 1 334 ? -9.379  -19.293 -15.102 0.25 45.01  ? 597  ASP   A C   1 
ATOM   2346 O  O   . ASP   A 1 334 ? -10.118 -19.377 -14.105 0.25 44.56  ? 597  ASP   A O   1 
ATOM   2347 C  CB  . ASP   A 1 334 ? -7.499  -17.781 -15.857 0.25 48.82  ? 597  ASP   A CB  1 
ATOM   2348 C  CG  . ASP   A 1 334 ? -6.654  -18.003 -14.616 0.25 50.05  ? 597  ASP   A CG  1 
ATOM   2349 O  OD1 . ASP   A 1 334 ? -7.237  -18.094 -13.522 0.25 52.21  ? 597  ASP   A OD1 1 
ATOM   2350 O  OD2 . ASP   A 1 334 ? -5.420  -18.085 -14.758 0.25 51.62  ? 597  ASP   A OD2 1 
ATOM   2351 N  N   . GLN   A 1 335 ? -8.889  -20.334 -15.782 0.25 43.51  ? 598  GLN   A N   1 
ATOM   2352 C  CA  . GLN   A 1 335 ? -9.191  -21.746 -15.412 0.25 42.37  ? 598  GLN   A CA  1 
ATOM   2353 C  C   . GLN   A 1 335 ? -10.595 -22.115 -15.901 0.25 42.23  ? 598  GLN   A C   1 
ATOM   2354 O  O   . GLN   A 1 335 ? -11.395 -21.198 -16.160 0.25 41.80  ? 598  GLN   A O   1 
ATOM   2355 C  CB  . GLN   A 1 335 ? -9.016  -21.994 -13.911 0.25 42.24  ? 598  GLN   A CB  1 
ATOM   2356 C  CG  . GLN   A 1 335 ? -7.569  -21.914 -13.448 0.25 42.19  ? 598  GLN   A CG  1 
ATOM   2357 C  CD  . GLN   A 1 335 ? -7.356  -22.592 -12.117 0.25 42.75  ? 598  GLN   A CD  1 
ATOM   2358 O  OE1 . GLN   A 1 335 ? -8.271  -23.177 -11.543 0.25 44.50  ? 598  GLN   A OE1 1 
ATOM   2359 N  NE2 . GLN   A 1 335 ? -6.133  -22.524 -11.619 0.25 42.14  ? 598  GLN   A NE2 1 
ATOM   2360 N  N   . ARG   A 1 336 ? -10.867 -23.413 -16.026 1.00 40.98  ? 599  ARG   A N   1 
ATOM   2361 C  CA  . ARG   A 1 336 ? -12.193 -23.892 -16.485 1.00 45.50  ? 599  ARG   A CA  1 
ATOM   2362 C  C   . ARG   A 1 336 ? -13.111 -24.150 -15.294 1.00 50.40  ? 599  ARG   A C   1 
ATOM   2363 O  O   . ARG   A 1 336 ? -12.692 -24.853 -14.371 1.00 49.81  ? 599  ARG   A O   1 
ATOM   2364 C  CB  . ARG   A 1 336 ? -12.078 -25.165 -17.328 1.00 42.41  ? 599  ARG   A CB  1 
ATOM   2365 C  CG  . ARG   A 1 336 ? -13.415 -25.779 -17.716 1.00 39.47  ? 599  ARG   A CG  1 
ATOM   2366 C  CD  . ARG   A 1 336 ? -13.995 -25.105 -18.939 1.00 37.93  ? 599  ARG   A CD  1 
ATOM   2367 N  NE  . ARG   A 1 336 ? -13.223 -25.449 -20.120 1.00 36.84  ? 599  ARG   A NE  1 
ATOM   2368 C  CZ  . ARG   A 1 336 ? -12.919 -24.604 -21.092 1.00 36.69  ? 599  ARG   A CZ  1 
ATOM   2369 N  NH1 . ARG   A 1 336 ? -13.324 -23.349 -21.025 1.00 33.61  ? 599  ARG   A NH1 1 
ATOM   2370 N  NH2 . ARG   A 1 336 ? -12.213 -25.018 -22.126 1.00 32.20  ? 599  ARG   A NH2 1 
ATOM   2371 N  N   . GLY   A 1 337 ? -14.320 -23.591 -15.341 0.25 54.01  ? 600  GLY   A N   1 
ATOM   2372 C  CA  . GLY   A 1 337 ? -15.322 -23.795 -14.280 0.25 57.25  ? 600  GLY   A CA  1 
ATOM   2373 C  C   . GLY   A 1 337 ? -16.700 -23.637 -14.889 0.25 60.39  ? 600  GLY   A C   1 
ATOM   2374 O  O   . GLY   A 1 337 ? -17.242 -22.522 -14.825 0.25 66.87  ? 600  GLY   A O   1 
ATOM   2375 N  N   . SER   A 1 338 ? -17.222 -24.697 -15.505 0.25 61.72  ? 601  SER   A N   1 
ATOM   2376 C  CA  . SER   A 1 338 ? -18.534 -24.635 -16.201 0.25 61.17  ? 601  SER   A CA  1 
ATOM   2377 C  C   . SER   A 1 338 ? -19.295 -25.935 -15.929 0.25 61.91  ? 601  SER   A C   1 
ATOM   2378 O  O   . SER   A 1 338 ? -18.781 -26.753 -15.136 0.25 61.66  ? 601  SER   A O   1 
ATOM   2379 C  CB  . SER   A 1 338 ? -18.337 -24.407 -17.680 0.25 62.18  ? 601  SER   A CB  1 
ATOM   2380 O  OG  . SER   A 1 338 ? -17.388 -23.377 -17.914 0.25 64.26  ? 601  SER   A OG  1 
ATOM   2381 N  N   . GLY   A 1 339 ? -20.466 -26.122 -16.551 1.00 62.70  ? 602  GLY   A N   1 
ATOM   2382 C  CA  . GLY   A 1 339 ? -21.155 -27.423 -16.519 1.00 59.01  ? 602  GLY   A CA  1 
ATOM   2383 C  C   . GLY   A 1 339 ? -20.255 -28.414 -17.224 1.00 54.34  ? 602  GLY   A C   1 
ATOM   2384 O  O   . GLY   A 1 339 ? -19.524 -28.006 -18.153 1.00 48.92  ? 602  GLY   A O   1 
ATOM   2385 N  N   . GLN   A 1 340 ? -20.294 -29.678 -16.791 0.25 53.29  ? 603  GLN   A N   1 
ATOM   2386 C  CA  . GLN   A 1 340 ? -19.443 -30.779 -17.318 0.25 54.25  ? 603  GLN   A CA  1 
ATOM   2387 C  C   . GLN   A 1 340 ? -19.671 -30.931 -18.830 0.25 52.55  ? 603  GLN   A C   1 
ATOM   2388 O  O   . GLN   A 1 340 ? -18.693 -31.221 -19.539 0.25 51.63  ? 603  GLN   A O   1 
ATOM   2389 C  CB  . GLN   A 1 340 ? -19.715 -32.084 -16.562 0.25 57.14  ? 603  GLN   A CB  1 
ATOM   2390 C  CG  . GLN   A 1 340 ? -21.136 -32.616 -16.711 0.25 60.29  ? 603  GLN   A CG  1 
ATOM   2391 C  CD  . GLN   A 1 340 ? -21.318 -33.985 -16.097 0.25 62.73  ? 603  GLN   A CD  1 
ATOM   2392 O  OE1 . GLN   A 1 340 ? -20.606 -34.371 -15.171 0.25 63.81  ? 603  GLN   A OE1 1 
ATOM   2393 N  NE2 . GLN   A 1 340 ? -22.280 -34.734 -16.611 0.25 62.83  ? 603  GLN   A NE2 1 
ATOM   2394 N  N   . VAL   A 1 341 ? -20.905 -30.731 -19.303 1.00 51.52  ? 604  VAL   A N   1 
ATOM   2395 C  CA  . VAL   A 1 341 ? -21.248 -30.905 -20.755 1.00 46.71  ? 604  VAL   A CA  1 
ATOM   2396 C  C   . VAL   A 1 341 ? -20.685 -29.734 -21.579 1.00 44.71  ? 604  VAL   A C   1 
ATOM   2397 O  O   . VAL   A 1 341 ? -20.001 -29.997 -22.633 1.00 36.45  ? 604  VAL   A O   1 
ATOM   2398 C  CB  . VAL   A 1 341 ? -22.759 -31.120 -20.955 1.00 47.09  ? 604  VAL   A CB  1 
ATOM   2399 C  CG1 . VAL   A 1 341 ? -23.113 -31.111 -22.436 1.00 57.01  ? 604  VAL   A CG1 1 
ATOM   2400 C  CG2 . VAL   A 1 341 ? -23.216 -32.424 -20.296 1.00 51.23  ? 604  VAL   A CG2 1 
ATOM   2401 N  N   . VAL   A 1 342 ? -20.912 -28.477 -21.161 1.00 38.81  ? 605  VAL   A N   1 
ATOM   2402 C  CA  . VAL   A 1 342 ? -20.211 -27.351 -21.844 1.00 40.56  ? 605  VAL   A CA  1 
ATOM   2403 C  C   . VAL   A 1 342 ? -18.688 -27.481 -21.679 1.00 34.65  ? 605  VAL   A C   1 
ATOM   2404 O  O   . VAL   A 1 342 ? -17.958 -27.233 -22.624 1.00 33.59  ? 605  VAL   A O   1 
ATOM   2405 C  CB  . VAL   A 1 342 ? -20.743 -25.996 -21.357 1.00 42.74  ? 605  VAL   A CB  1 
ATOM   2406 C  CG1 . VAL   A 1 342 ? -20.007 -24.854 -22.033 1.00 43.06  ? 605  VAL   A CG1 1 
ATOM   2407 C  CG2 . VAL   A 1 342 ? -22.243 -25.896 -21.619 1.00 44.17  ? 605  VAL   A CG2 1 
ATOM   2408 N  N   . THR   A 1 343 ? -18.191 -27.805 -20.495 1.00 32.31  ? 606  THR   A N   1 
ATOM   2409 C  CA  . THR   A 1 343 ? -16.750 -28.077 -20.304 1.00 35.16  ? 606  THR   A CA  1 
ATOM   2410 C  C   . THR   A 1 343 ? -16.240 -29.063 -21.363 1.00 32.75  ? 606  THR   A C   1 
ATOM   2411 O  O   . THR   A 1 343 ? -15.204 -28.797 -21.918 1.00 30.30  ? 606  THR   A O   1 
ATOM   2412 C  CB  . THR   A 1 343 ? -16.444 -28.644 -18.918 1.00 37.38  ? 606  THR   A CB  1 
ATOM   2413 O  OG1 . THR   A 1 343 ? -16.797 -27.605 -18.026 1.00 37.91  ? 606  THR   A OG1 1 
ATOM   2414 C  CG2 . THR   A 1 343 ? -14.991 -29.022 -18.733 1.00 39.54  ? 606  THR   A CG2 1 
ATOM   2415 N  N   . TYR   A 1 344 ? -16.976 -30.138 -21.650 1.00 29.81  ? 607  TYR   A N   1 
ATOM   2416 C  CA  . TYR   A 1 344 ? -16.514 -31.165 -22.582 1.00 31.22  ? 607  TYR   A CA  1 
ATOM   2417 C  C   . TYR   A 1 344 ? -16.324 -30.533 -23.958 1.00 33.01  ? 607  TYR   A C   1 
ATOM   2418 O  O   . TYR   A 1 344 ? -15.255 -30.811 -24.576 1.00 29.35  ? 607  TYR   A O   1 
ATOM   2419 C  CB  . TYR   A 1 344 ? -17.445 -32.381 -22.610 1.00 34.74  ? 607  TYR   A CB  1 
ATOM   2420 C  CG  . TYR   A 1 344 ? -17.061 -33.390 -23.656 1.00 30.68  ? 607  TYR   A CG  1 
ATOM   2421 C  CD1 . TYR   A 1 344 ? -16.060 -34.305 -23.408 1.00 32.98  ? 607  TYR   A CD1 1 
ATOM   2422 C  CD2 . TYR   A 1 344 ? -17.637 -33.378 -24.921 1.00 32.73  ? 607  TYR   A CD2 1 
ATOM   2423 C  CE1 . TYR   A 1 344 ? -15.673 -35.226 -24.363 1.00 29.68  ? 607  TYR   A CE1 1 
ATOM   2424 C  CE2 . TYR   A 1 344 ? -17.282 -34.307 -25.882 1.00 34.87  ? 607  TYR   A CE2 1 
ATOM   2425 C  CZ  . TYR   A 1 344 ? -16.305 -35.245 -25.600 1.00 34.83  ? 607  TYR   A CZ  1 
ATOM   2426 O  OH  . TYR   A 1 344 ? -15.940 -36.124 -26.576 1.00 36.62  ? 607  TYR   A OH  1 
ATOM   2427 N  N   . GLY   A 1 345 ? -17.284 -29.707 -24.422 1.00 28.94  ? 608  GLY   A N   1 
ATOM   2428 C  CA  . GLY   A 1 345 ? -17.252 -29.198 -25.805 1.00 26.70  ? 608  GLY   A CA  1 
ATOM   2429 C  C   . GLY   A 1 345 ? -16.183 -28.109 -25.972 1.00 26.29  ? 608  GLY   A C   1 
ATOM   2430 O  O   . GLY   A 1 345 ? -15.468 -28.135 -26.944 1.00 28.15  ? 608  GLY   A O   1 
ATOM   2431 N  N   . LEU   A 1 346 ? -16.005 -27.257 -24.983 1.00 24.90  ? 609  LEU   A N   1 
ATOM   2432 C  CA  . LEU   A 1 346 ? -14.982 -26.200 -25.065 1.00 30.53  ? 609  LEU   A CA  1 
ATOM   2433 C  C   . LEU   A 1 346 ? -13.564 -26.786 -24.865 1.00 27.01  ? 609  LEU   A C   1 
ATOM   2434 O  O   . LEU   A 1 346 ? -12.642 -26.250 -25.512 1.00 29.01  ? 609  LEU   A O   1 
ATOM   2435 C  CB  . LEU   A 1 346 ? -15.310 -25.112 -24.040 1.00 27.84  ? 609  LEU   A CB  1 
ATOM   2436 C  CG  . LEU   A 1 346 ? -16.644 -24.417 -24.235 1.00 30.23  ? 609  LEU   A CG  1 
ATOM   2437 C  CD1 . LEU   A 1 346 ? -16.830 -23.378 -23.159 1.00 34.81  ? 609  LEU   A CD1 1 
ATOM   2438 C  CD2 . LEU   A 1 346 ? -16.732 -23.808 -25.632 1.00 29.80  ? 609  LEU   A CD2 1 
ATOM   2439 N  N   . ASN   A 1 347 ? -13.393 -27.780 -23.995 1.00 28.96  ? 610  ASN   A N   1 
ATOM   2440 C  CA  . ASN   A 1 347 ? -12.121 -28.555 -23.900 1.00 27.02  ? 610  ASN   A CA  1 
ATOM   2441 C  C   . ASN   A 1 347 ? -11.819 -29.169 -25.269 1.00 26.41  ? 610  ASN   A C   1 
ATOM   2442 O  O   . ASN   A 1 347 ? -10.703 -28.979 -25.768 1.00 24.08  ? 610  ASN   A O   1 
ATOM   2443 C  CB  . ASN   A 1 347 ? -12.172 -29.582 -22.772 1.00 26.59  ? 610  ASN   A CB  1 
ATOM   2444 C  CG  . ASN   A 1 347 ? -12.018 -28.957 -21.411 1.00 28.11  ? 610  ASN   A CG  1 
ATOM   2445 O  OD1 . ASN   A 1 347 ? -11.665 -27.785 -21.263 1.00 28.81  ? 610  ASN   A OD1 1 
ATOM   2446 N  ND2 . ASN   A 1 347 ? -12.189 -29.761 -20.384 1.00 31.71  ? 610  ASN   A ND2 1 
ATOM   2447 N  N   . THR   A 1 348 ? -12.787 -29.799 -25.937 1.00 25.08  ? 611  THR   A N   1 
ATOM   2448 C  CA  . THR   A 1 348 ? -12.549 -30.379 -27.266 1.00 23.03  ? 611  THR   A CA  1 
ATOM   2449 C  C   . THR   A 1 348 ? -12.085 -29.275 -28.232 1.00 27.49  ? 611  THR   A C   1 
ATOM   2450 O  O   . THR   A 1 348 ? -11.122 -29.504 -28.969 1.00 26.07  ? 611  THR   A O   1 
ATOM   2451 C  CB  . THR   A 1 348 ? -13.753 -31.144 -27.792 1.00 24.32  ? 611  THR   A CB  1 
ATOM   2452 O  OG1 . THR   A 1 348 ? -14.185 -32.135 -26.864 1.00 25.53  ? 611  THR   A OG1 1 
ATOM   2453 C  CG2 . THR   A 1 348 ? -13.459 -31.764 -29.114 1.00 23.92  ? 611  THR   A CG2 1 
ATOM   2454 N  N   . PHE   A 1 349 ? -12.793 -28.147 -28.274 1.00 25.58  ? 612  PHE   A N   1 
ATOM   2455 C  CA  . PHE   A 1 349 ? -12.483 -27.015 -29.181 1.00 28.76  ? 612  PHE   A CA  1 
ATOM   2456 C  C   . PHE   A 1 349 ? -11.035 -26.547 -28.967 1.00 26.94  ? 612  PHE   A C   1 
ATOM   2457 O  O   . PHE   A 1 349 ? -10.292 -26.456 -29.942 1.00 26.36  ? 612  PHE   A O   1 
ATOM   2458 C  CB  . PHE   A 1 349 ? -13.451 -25.862 -28.915 1.00 27.12  ? 612  PHE   A CB  1 
ATOM   2459 C  CG  . PHE   A 1 349 ? -13.168 -24.680 -29.782 1.00 27.38  ? 612  PHE   A CG  1 
ATOM   2460 C  CD1 . PHE   A 1 349 ? -13.721 -24.592 -31.045 1.00 30.74  ? 612  PHE   A CD1 1 
ATOM   2461 C  CD2 . PHE   A 1 349 ? -12.329 -23.667 -29.336 1.00 27.94  ? 612  PHE   A CD2 1 
ATOM   2462 C  CE1 . PHE   A 1 349 ? -13.419 -23.508 -31.862 1.00 30.29  ? 612  PHE   A CE1 1 
ATOM   2463 C  CE2 . PHE   A 1 349 ? -12.060 -22.575 -30.140 1.00 28.19  ? 612  PHE   A CE2 1 
ATOM   2464 C  CZ  . PHE   A 1 349 ? -12.584 -22.511 -31.404 1.00 29.78  ? 612  PHE   A CZ  1 
ATOM   2465 N  N   . THR   A 1 350 ? -10.682 -26.243 -27.725 1.00 24.27  ? 613  THR   A N   1 
ATOM   2466 C  CA  . THR   A 1 350 ? -9.397  -25.623 -27.367 1.00 30.13  ? 613  THR   A CA  1 
ATOM   2467 C  C   . THR   A 1 350 ? -8.275  -26.669 -27.568 1.00 28.67  ? 613  THR   A C   1 
ATOM   2468 O  O   . THR   A 1 350 ? -7.194  -26.291 -28.005 1.00 28.90  ? 613  THR   A O   1 
ATOM   2469 C  CB  . THR   A 1 350 ? -9.447  -24.962 -25.987 1.00 33.53  ? 613  THR   A CB  1 
ATOM   2470 O  OG1 . THR   A 1 350 ? -10.351 -23.855 -26.033 1.00 29.27  ? 613  THR   A OG1 1 
ATOM   2471 C  CG2 . THR   A 1 350 ? -8.073  -24.445 -25.607 1.00 36.17  ? 613  THR   A CG2 1 
ATOM   2472 N  N   . ASN   A 1 351 ? -8.566  -27.966 -27.387 1.00 26.71  ? 614  ASN   A N   1 
ATOM   2473 C  CA  . ASN   A 1 351 ? -7.588  -29.052 -27.631 1.00 26.18  ? 614  ASN   A CA  1 
ATOM   2474 C  C   . ASN   A 1 351 ? -7.376  -29.178 -29.140 1.00 27.61  ? 614  ASN   A C   1 
ATOM   2475 O  O   . ASN   A 1 351 ? -6.189  -29.265 -29.561 1.00 24.89  ? 614  ASN   A O   1 
ATOM   2476 C  CB  . ASN   A 1 351 ? -7.988  -30.334 -26.891 1.00 25.81  ? 614  ASN   A CB  1 
ATOM   2477 C  CG  . ASN   A 1 351 ? -6.814  -31.266 -26.610 1.00 29.65  ? 614  ASN   A CG  1 
ATOM   2478 O  OD1 . ASN   A 1 351 ? -5.663  -30.937 -26.901 1.00 28.69  ? 614  ASN   A OD1 1 
ATOM   2479 N  ND2 . ASN   A 1 351 ? -7.103  -32.441 -26.067 1.00 29.73  ? 614  ASN   A ND2 1 
ATOM   2480 N  N   . MET   A 1 352 ? -8.446  -29.064 -29.945 1.00 22.78  ? 615  MET   A N   1 
ATOM   2481 C  CA  . MET   A 1 352 ? -8.287  -29.169 -31.399 1.00 24.94  ? 615  MET   A CA  1 
ATOM   2482 C  C   . MET   A 1 352 ? -7.368  -28.014 -31.848 1.00 26.41  ? 615  MET   A C   1 
ATOM   2483 O  O   . MET   A 1 352 ? -6.483  -28.242 -32.718 1.00 28.20  ? 615  MET   A O   1 
ATOM   2484 C  CB  . MET   A 1 352 ? -9.616  -29.104 -32.164 1.00 25.01  ? 615  MET   A CB  1 
ATOM   2485 C  CG  . MET   A 1 352 ? -10.496 -30.310 -31.973 1.00 26.50  ? 615  MET   A CG  1 
ATOM   2486 S  SD  . MET   A 1 352 ? -12.214 -30.025 -32.647 1.00 32.71  ? 615  MET   A SD  1 
ATOM   2487 C  CE  . MET   A 1 352 ? -11.881 -29.816 -34.373 1.00 28.17  ? 615  MET   A CE  1 
ATOM   2488 N  N   . GLU   A 1 353 ? -7.579  -26.838 -31.297 1.00 26.64  ? 616  GLU   A N   1 
ATOM   2489 C  CA  . GLU   A 1 353 ? -6.826  -25.604 -31.673 1.00 28.81  ? 616  GLU   A CA  1 
ATOM   2490 C  C   . GLU   A 1 353 ? -5.340  -25.818 -31.319 1.00 27.25  ? 616  GLU   A C   1 
ATOM   2491 O  O   . GLU   A 1 353 ? -4.484  -25.627 -32.158 1.00 28.36  ? 616  GLU   A O   1 
ATOM   2492 C  CB  . GLU   A 1 353 ? -7.464  -24.448 -30.903 1.00 29.67  ? 616  GLU   A CB  1 
ATOM   2493 C  CG  . GLU   A 1 353 ? -6.840  -23.092 -31.144 1.00 36.36  ? 616  GLU   A CG  1 
ATOM   2494 C  CD  . GLU   A 1 353 ? -7.130  -22.101 -30.022 1.00 38.42  ? 616  GLU   A CD  1 
ATOM   2495 O  OE1 . GLU   A 1 353 ? -8.335  -21.743 -29.850 1.00 39.51  ? 616  GLU   A OE1 1 
ATOM   2496 O  OE2 . GLU   A 1 353 ? -6.157  -21.821 -29.211 1.00 39.07  ? 616  GLU   A OE2 1 
ATOM   2497 N  N   . ALA   A 1 354 ? -5.059  -26.174 -30.080 1.00 25.85  ? 617  ALA   A N   1 
ATOM   2498 C  CA  . ALA   A 1 354 ? -3.701  -26.432 -29.573 1.00 27.86  ? 617  ALA   A CA  1 
ATOM   2499 C  C   . ALA   A 1 354 ? -2.992  -27.487 -30.407 1.00 28.81  ? 617  ALA   A C   1 
ATOM   2500 O  O   . ALA   A 1 354 ? -1.843  -27.261 -30.778 1.00 27.71  ? 617  ALA   A O   1 
ATOM   2501 C  CB  . ALA   A 1 354 ? -3.808  -26.869 -28.175 1.00 25.54  ? 617  ALA   A CB  1 
ATOM   2502 N  N   . GLN   A 1 355 ? -3.675  -28.586 -30.742 1.00 24.28  ? 618  GLN   A N   1 
ATOM   2503 C  CA  . GLN   A 1 355 ? -3.012  -29.635 -31.535 1.00 22.73  ? 618  GLN   A CA  1 
ATOM   2504 C  C   . GLN   A 1 355 ? -2.803  -29.187 -32.992 1.00 27.99  ? 618  GLN   A C   1 
ATOM   2505 O  O   . GLN   A 1 355 ? -1.776  -29.624 -33.594 1.00 28.06  ? 618  GLN   A O   1 
ATOM   2506 C  CB  . GLN   A 1 355 ? -3.730  -30.968 -31.416 1.00 24.01  ? 618  GLN   A CB  1 
ATOM   2507 C  CG  . GLN   A 1 355 ? -3.965  -31.459 -30.017 1.00 22.34  ? 618  GLN   A CG  1 
ATOM   2508 C  CD  . GLN   A 1 355 ? -2.685  -31.629 -29.248 1.00 27.81  ? 618  GLN   A CD  1 
ATOM   2509 O  OE1 . GLN   A 1 355 ? -1.646  -32.023 -29.750 1.00 29.30  ? 618  GLN   A OE1 1 
ATOM   2510 N  NE2 . GLN   A 1 355 ? -2.775  -31.367 -27.966 1.00 28.60  ? 618  GLN   A NE2 1 
ATOM   2511 N  N   . LEU   A 1 356 ? -3.667  -28.367 -33.608 1.00 28.32  ? 619  LEU   A N   1 
ATOM   2512 C  CA  . LEU   A 1 356 ? -3.395  -27.868 -34.999 1.00 29.36  ? 619  LEU   A CA  1 
ATOM   2513 C  C   . LEU   A 1 356 ? -2.132  -26.970 -34.966 1.00 27.73  ? 619  LEU   A C   1 
ATOM   2514 O  O   . LEU   A 1 356 ? -1.328  -27.032 -35.870 1.00 31.57  ? 619  LEU   A O   1 
ATOM   2515 C  CB  . LEU   A 1 356 ? -4.567  -27.042 -35.545 1.00 30.09  ? 619  LEU   A CB  1 
ATOM   2516 C  CG  . LEU   A 1 356 ? -5.700  -27.795 -36.224 1.00 32.56  ? 619  LEU   A CG  1 
ATOM   2517 C  CD1 . LEU   A 1 356 ? -6.815  -26.836 -36.587 1.00 35.74  ? 619  LEU   A CD1 1 
ATOM   2518 C  CD2 . LEU   A 1 356 ? -5.235  -28.561 -37.467 1.00 32.67  ? 619  LEU   A CD2 1 
ATOM   2519 N  N   . ILE   A 1 357 ? -1.999  -26.152 -33.952 1.00 27.17  ? 620  ILE   A N   1 
ATOM   2520 C  CA  . ILE   A 1 357 ? -0.836  -25.238 -33.767 1.00 30.48  ? 620  ILE   A CA  1 
ATOM   2521 C  C   . ILE   A 1 357 ? 0.424   -26.105 -33.559 1.00 37.06  ? 620  ILE   A C   1 
ATOM   2522 O  O   . ILE   A 1 357 ? 1.383   -25.912 -34.313 1.00 31.79  ? 620  ILE   A O   1 
ATOM   2523 C  CB  . ILE   A 1 357 ? -1.130  -24.272 -32.627 1.00 31.39  ? 620  ILE   A CB  1 
ATOM   2524 C  CG1 . ILE   A 1 357 ? -2.261  -23.316 -33.045 1.00 32.93  ? 620  ILE   A CG1 1 
ATOM   2525 C  CG2 . ILE   A 1 357 ? 0.132   -23.517 -32.232 1.00 35.77  ? 620  ILE   A CG2 1 
ATOM   2526 C  CD1 . ILE   A 1 357 ? -2.840  -22.497 -31.936 1.00 32.65  ? 620  ILE   A CD1 1 
ATOM   2527 N  N   . ARG   A 1 358 ? 0.370   -27.142 -32.705 1.00 31.26  ? 621  ARG   A N   1 
ATOM   2528 C  CA  . ARG   A 1 358 ? 1.529   -28.041 -32.544 1.00 29.89  ? 621  ARG   A CA  1 
ATOM   2529 C  C   . ARG   A 1 358 ? 1.863   -28.661 -33.890 1.00 31.31  ? 621  ARG   A C   1 
ATOM   2530 O  O   . ARG   A 1 358 ? 3.083   -28.694 -34.211 1.00 34.70  ? 621  ARG   A O   1 
ATOM   2531 C  CB  . ARG   A 1 358 ? 1.369   -29.102 -31.465 1.00 33.43  ? 621  ARG   A CB  1 
ATOM   2532 C  CG  . ARG   A 1 358 ? 2.642   -29.916 -31.307 1.00 30.45  ? 621  ARG   A CG  1 
ATOM   2533 C  CD  . ARG   A 1 358 ? 2.550   -30.798 -30.103 1.00 31.78  ? 621  ARG   A CD  1 
ATOM   2534 N  NE  . ARG   A 1 358 ? 3.701   -31.655 -29.995 1.00 29.20  ? 621  ARG   A NE  1 
ATOM   2535 C  CZ  . ARG   A 1 358 ? 3.877   -32.596 -29.074 1.00 31.37  ? 621  ARG   A CZ  1 
ATOM   2536 N  NH1 . ARG   A 1 358 ? 2.908   -32.976 -28.252 1.00 26.68  ? 621  ARG   A NH1 1 
ATOM   2537 N  NH2 . ARG   A 1 358 ? 5.030   -33.252 -29.064 1.00 33.89  ? 621  ARG   A NH2 1 
ATOM   2538 N  N   . GLN   A 1 359 ? 0.869   -29.099 -34.674 1.00 29.89  ? 622  GLN   A N   1 
ATOM   2539 C  CA  . GLN   A 1 359 ? 1.121   -29.581 -36.043 1.00 27.59  ? 622  GLN   A CA  1 
ATOM   2540 C  C   . GLN   A 1 359 ? 1.759   -28.435 -36.873 1.00 34.10  ? 622  GLN   A C   1 
ATOM   2541 O  O   . GLN   A 1 359 ? 2.718   -28.718 -37.608 1.00 35.00  ? 622  GLN   A O   1 
ATOM   2542 C  CB  . GLN   A 1 359 ? -0.100  -30.158 -36.732 1.00 29.45  ? 622  GLN   A CB  1 
ATOM   2543 C  CG  . GLN   A 1 359 ? -0.617  -31.468 -36.157 1.00 27.77  ? 622  GLN   A CG  1 
ATOM   2544 C  CD  . GLN   A 1 359 ? -1.629  -32.097 -37.065 1.00 28.49  ? 622  GLN   A CD  1 
ATOM   2545 O  OE1 . GLN   A 1 359 ? -1.313  -32.574 -38.152 1.00 27.46  ? 622  GLN   A OE1 1 
ATOM   2546 N  NE2 . GLN   A 1 359 ? -2.859  -32.192 -36.579 1.00 31.51  ? 622  GLN   A NE2 1 
ATOM   2547 N  N   . MET   A 1 360 ? 1.279   -27.201 -36.826 1.00 33.01  ? 623  MET   A N   1 
ATOM   2548 C  CA  . MET   A 1 360 ? 1.901   -26.107 -37.641 1.00 36.84  ? 623  MET   A CA  1 
ATOM   2549 C  C   . MET   A 1 360 ? 3.386   -25.957 -37.242 1.00 32.81  ? 623  MET   A C   1 
ATOM   2550 O  O   . MET   A 1 360 ? 4.222   -25.794 -38.136 1.00 35.63  ? 623  MET   A O   1 
ATOM   2551 C  CB  . MET   A 1 360 ? 1.215   -24.754 -37.428 1.00 36.21  ? 623  MET   A CB  1 
ATOM   2552 C  CG  . MET   A 1 360 ? -0.095  -24.573 -38.146 1.00 43.41  ? 623  MET   A CG  1 
ATOM   2553 S  SD  . MET   A 1 360 ? -0.826  -23.084 -37.413 1.00 41.51  ? 623  MET   A SD  1 
ATOM   2554 C  CE  . MET   A 1 360 ? -2.567  -23.417 -37.648 1.00 46.24  ? 623  MET   A CE  1 
ATOM   2555 N  N   . GLU   A 1 361 ? 3.682   -25.979 -35.952 1.00 28.18  ? 624  GLU   A N   1 
ATOM   2556 C  CA  . GLU   A 1 361 ? 5.066   -25.864 -35.469 1.00 32.26  ? 624  GLU   A CA  1 
ATOM   2557 C  C   . GLU   A 1 361 ? 5.939   -26.962 -36.061 1.00 40.35  ? 624  GLU   A C   1 
ATOM   2558 O  O   . GLU   A 1 361 ? 7.048   -26.647 -36.466 1.00 36.66  ? 624  GLU   A O   1 
ATOM   2559 C  CB  . GLU   A 1 361 ? 5.153   -25.914 -33.958 1.00 35.64  ? 624  GLU   A CB  1 
ATOM   2560 C  CG  . GLU   A 1 361 ? 6.493   -25.395 -33.468 1.00 40.03  ? 624  GLU   A CG  1 
ATOM   2561 C  CD  . GLU   A 1 361 ? 6.623   -25.226 -31.969 1.00 38.98  ? 624  GLU   A CD  1 
ATOM   2562 O  OE1 . GLU   A 1 361 ? 7.767   -25.227 -31.473 1.00 44.20  ? 624  GLU   A OE1 1 
ATOM   2563 O  OE2 . GLU   A 1 361 ? 5.580   -25.054 -31.293 1.00 41.48  ? 624  GLU   A OE2 1 
ATOM   2564 N  N   . GLY   A 1 362 ? 5.481   -28.212 -36.119 1.00 33.22  ? 625  GLY   A N   1 
ATOM   2565 C  CA  . GLY   A 1 362 ? 6.322   -29.308 -36.619 1.00 38.20  ? 625  GLY   A CA  1 
ATOM   2566 C  C   . GLY   A 1 362 ? 6.560   -29.170 -38.120 1.00 39.47  ? 625  GLY   A C   1 
ATOM   2567 O  O   . GLY   A 1 362 ? 7.597   -29.639 -38.606 1.00 35.66  ? 625  GLY   A O   1 
ATOM   2568 N  N   . GLU   A 1 363 ? 5.593   -28.626 -38.848 1.00 31.22  ? 626  GLU   A N   1 
ATOM   2569 C  CA  . GLU   A 1 363 ? 5.696   -28.489 -40.321 1.00 31.93  ? 626  GLU   A CA  1 
ATOM   2570 C  C   . GLU   A 1 363 ? 6.464   -27.200 -40.669 1.00 36.10  ? 626  GLU   A C   1 
ATOM   2571 O  O   . GLU   A 1 363 ? 6.597   -26.934 -41.839 1.00 37.15  ? 626  GLU   A O   1 
ATOM   2572 C  CB  . GLU   A 1 363 ? 4.300   -28.495 -40.932 1.00 29.93  ? 626  GLU   A CB  1 
ATOM   2573 C  CG  . GLU   A 1 363 ? 3.672   -29.888 -40.903 1.00 35.61  ? 626  GLU   A CG  1 
ATOM   2574 C  CD  . GLU   A 1 363 ? 2.266   -30.006 -41.474 1.00 42.54  ? 626  GLU   A CD  1 
ATOM   2575 O  OE1 . GLU   A 1 363 ? 2.057   -29.427 -42.567 1.00 37.52  ? 626  GLU   A OE1 1 
ATOM   2576 O  OE2 . GLU   A 1 363 ? 1.380   -30.689 -40.827 1.00 35.19  ? 626  GLU   A OE2 1 
ATOM   2577 N  N   . GLY   A 1 364 ? 6.904   -26.409 -39.696 1.00 33.06  ? 627  GLY   A N   1 
ATOM   2578 C  CA  . GLY   A 1 364 ? 7.705   -25.197 -39.964 1.00 39.91  ? 627  GLY   A CA  1 
ATOM   2579 C  C   . GLY   A 1 364 ? 6.870   -24.051 -40.525 1.00 48.49  ? 627  GLY   A C   1 
ATOM   2580 O  O   . GLY   A 1 364 ? 7.434   -23.271 -41.327 1.00 48.03  ? 627  GLY   A O   1 
ATOM   2581 N  N   . VAL   A 1 365 ? 5.580   -23.924 -40.161 1.00 39.10  ? 628  VAL   A N   1 
ATOM   2582 C  CA  . VAL   A 1 365 ? 4.675   -22.925 -40.799 1.00 40.64  ? 628  VAL   A CA  1 
ATOM   2583 C  C   . VAL   A 1 365 ? 5.053   -21.552 -40.252 1.00 41.28  ? 628  VAL   A C   1 
ATOM   2584 O  O   . VAL   A 1 365 ? 4.857   -20.558 -40.943 1.00 42.02  ? 628  VAL   A O   1 
ATOM   2585 C  CB  . VAL   A 1 365 ? 3.189   -23.262 -40.582 1.00 43.48  ? 628  VAL   A CB  1 
ATOM   2586 C  CG1 . VAL   A 1 365 ? 2.298   -22.141 -41.074 1.00 41.88  ? 628  VAL   A CG1 1 
ATOM   2587 C  CG2 . VAL   A 1 365 ? 2.820   -24.564 -41.273 1.00 43.64  ? 628  VAL   A CG2 1 
ATOM   2588 N  N   . PHE   A 1 366 ? 5.559   -21.527 -39.027 1.00 42.48  ? 629  PHE   A N   1 
ATOM   2589 C  CA  . PHE   A 1 366 ? 6.022   -20.321 -38.305 1.00 46.86  ? 629  PHE   A CA  1 
ATOM   2590 C  C   . PHE   A 1 366 ? 7.360   -20.648 -37.630 1.00 52.39  ? 629  PHE   A C   1 
ATOM   2591 O  O   . PHE   A 1 366 ? 7.628   -21.812 -37.385 1.00 50.77  ? 629  PHE   A O   1 
ATOM   2592 C  CB  . PHE   A 1 366 ? 4.952   -19.837 -37.324 1.00 46.28  ? 629  PHE   A CB  1 
ATOM   2593 C  CG  . PHE   A 1 366 ? 4.738   -20.692 -36.113 1.00 45.32  ? 629  PHE   A CG  1 
ATOM   2594 C  CD1 . PHE   A 1 366 ? 3.759   -21.673 -36.117 1.00 41.11  ? 629  PHE   A CD1 1 
ATOM   2595 C  CD2 . PHE   A 1 366 ? 5.449   -20.465 -34.945 1.00 45.87  ? 629  PHE   A CD2 1 
ATOM   2596 C  CE1 . PHE   A 1 366 ? 3.560   -22.469 -35.001 1.00 39.66  ? 629  PHE   A CE1 1 
ATOM   2597 C  CE2 . PHE   A 1 366 ? 5.243   -21.266 -33.835 1.00 50.58  ? 629  PHE   A CE2 1 
ATOM   2598 C  CZ  . PHE   A 1 366 ? 4.308   -22.279 -33.873 1.00 39.60  ? 629  PHE   A CZ  1 
ATOM   2599 N  N   . LYS   A 1 367 ? 8.211   -19.651 -37.386 1.00 58.83  ? 630  LYS   A N   1 
ATOM   2600 C  CA  . LYS   A 1 367 ? 9.614   -19.891 -36.959 1.00 58.03  ? 630  LYS   A CA  1 
ATOM   2601 C  C   . LYS   A 1 367 ? 9.713   -19.719 -35.445 1.00 52.36  ? 630  LYS   A C   1 
ATOM   2602 O  O   . LYS   A 1 367 ? 10.485  -20.453 -34.816 1.00 56.18  ? 630  LYS   A O   1 
ATOM   2603 C  CB  . LYS   A 1 367 ? 10.549  -18.949 -37.723 1.00 76.49  ? 630  LYS   A CB  1 
ATOM   2604 C  CG  . LYS   A 1 367 ? 12.035  -19.237 -37.552 1.00 89.09  ? 630  LYS   A CG  1 
ATOM   2605 C  CD  . LYS   A 1 367 ? 12.926  -18.343 -38.392 1.00 96.86  ? 630  LYS   A CD  1 
ATOM   2606 C  CE  . LYS   A 1 367 ? 14.351  -18.276 -37.882 1.00 102.59 ? 630  LYS   A CE  1 
ATOM   2607 N  NZ  . LYS   A 1 367 ? 14.463  -17.431 -36.667 1.00 107.69 ? 630  LYS   A NZ  1 
ATOM   2608 N  N   . SER   A 1 368 ? 8.948   -18.799 -34.868 1.00 47.84  ? 631  SER   A N   1 
ATOM   2609 C  CA  . SER   A 1 368 ? 9.067   -18.424 -33.438 1.00 47.81  ? 631  SER   A CA  1 
ATOM   2610 C  C   . SER   A 1 368 ? 7.744   -17.921 -32.874 1.00 45.91  ? 631  SER   A C   1 
ATOM   2611 O  O   . SER   A 1 368 ? 7.051   -17.161 -33.562 1.00 48.36  ? 631  SER   A O   1 
ATOM   2612 C  CB  . SER   A 1 368 ? 10.078  -17.349 -33.243 1.00 54.20  ? 631  SER   A CB  1 
ATOM   2613 O  OG  . SER   A 1 368 ? 10.118  -16.968 -31.873 1.00 59.71  ? 631  SER   A OG  1 
ATOM   2614 N  N   . ILE   A 1 369 ? 7.499   -18.236 -31.608 1.00 47.52  ? 632  ILE   A N   1 
ATOM   2615 C  CA  . ILE   A 1 369 ? 6.268   -17.845 -30.867 1.00 51.29  ? 632  ILE   A CA  1 
ATOM   2616 C  C   . ILE   A 1 369 ? 6.413   -16.409 -30.356 1.00 52.42  ? 632  ILE   A C   1 
ATOM   2617 O  O   . ILE   A 1 369 ? 5.436   -15.887 -29.748 1.00 47.41  ? 632  ILE   A O   1 
ATOM   2618 C  CB  . ILE   A 1 369 ? 6.009   -18.820 -29.708 1.00 47.40  ? 632  ILE   A CB  1 
ATOM   2619 C  CG1 . ILE   A 1 369 ? 7.146   -18.801 -28.698 1.00 42.13  ? 632  ILE   A CG1 1 
ATOM   2620 C  CG2 . ILE   A 1 369 ? 5.743   -20.220 -30.236 1.00 53.50  ? 632  ILE   A CG2 1 
ATOM   2621 C  CD1 . ILE   A 1 369 ? 6.846   -19.554 -27.461 1.00 48.75  ? 632  ILE   A CD1 1 
ATOM   2622 N  N   . GLN   A 1 370 ? 7.612   -15.833 -30.474 1.00 60.14  ? 633  GLN   A N   1 
ATOM   2623 C  CA  . GLN   A 1 370 ? 7.897   -14.501 -29.878 1.00 61.70  ? 633  GLN   A CA  1 
ATOM   2624 C  C   . GLN   A 1 370 ? 6.990   -13.500 -30.592 1.00 52.05  ? 633  GLN   A C   1 
ATOM   2625 O  O   . GLN   A 1 370 ? 6.396   -12.633 -29.925 1.00 49.55  ? 633  GLN   A O   1 
ATOM   2626 C  CB  . GLN   A 1 370 ? 9.391   -14.170 -29.936 1.00 59.04  ? 633  GLN   A CB  1 
ATOM   2627 C  CG  . GLN   A 1 370 ? 9.940   -13.723 -28.579 1.00 71.31  ? 633  GLN   A CG  1 
ATOM   2628 C  CD  . GLN   A 1 370 ? 9.992   -14.801 -27.513 1.00 71.62  ? 633  GLN   A CD  1 
ATOM   2629 O  OE1 . GLN   A 1 370 ? 10.034  -15.991 -27.809 1.00 80.83  ? 633  GLN   A OE1 1 
ATOM   2630 N  NE2 . GLN   A 1 370 ? 10.013  -14.398 -26.250 1.00 71.17  ? 633  GLN   A NE2 1 
ATOM   2631 N  N   . HIS   A 1 371 ? 6.835   -13.671 -31.903 1.00 52.67  ? 634  HIS   A N   1 
ATOM   2632 C  CA  . HIS   A 1 371 ? 6.138   -12.702 -32.771 1.00 55.62  ? 634  HIS   A CA  1 
ATOM   2633 C  C   . HIS   A 1 371 ? 5.960   -13.346 -34.144 1.00 56.90  ? 634  HIS   A C   1 
ATOM   2634 O  O   . HIS   A 1 371 ? 6.945   -13.942 -34.682 1.00 50.48  ? 634  HIS   A O   1 
ATOM   2635 C  CB  . HIS   A 1 371 ? 6.950   -11.384 -32.765 1.00 71.88  ? 634  HIS   A CB  1 
ATOM   2636 C  CG  . HIS   A 1 371 ? 6.855   -10.573 -34.015 1.00 81.50  ? 634  HIS   A CG  1 
ATOM   2637 N  ND1 . HIS   A 1 371 ? 5.880   -9.596  -34.193 1.00 95.19  ? 634  HIS   A ND1 1 
ATOM   2638 C  CD2 . HIS   A 1 371 ? 7.606   -10.576 -35.142 1.00 88.37  ? 634  HIS   A CD2 1 
ATOM   2639 C  CE1 . HIS   A 1 371 ? 6.033   -9.038  -35.384 1.00 99.85  ? 634  HIS   A CE1 1 
ATOM   2640 N  NE2 . HIS   A 1 371 ? 7.082   -9.629  -35.991 1.00 95.29  ? 634  HIS   A NE2 1 
ATOM   2641 N  N   . LEU   A 1 372 ? 4.733   -13.263 -34.659 1.00 56.54  ? 635  LEU   A N   1 
ATOM   2642 C  CA  . LEU   A 1 372 ? 4.368   -13.610 -36.054 1.00 62.55  ? 635  LEU   A CA  1 
ATOM   2643 C  C   . LEU   A 1 372 ? 4.573   -12.355 -36.892 1.00 65.89  ? 635  LEU   A C   1 
ATOM   2644 O  O   . LEU   A 1 372 ? 4.115   -11.295 -36.474 1.00 69.52  ? 635  LEU   A O   1 
ATOM   2645 C  CB  . LEU   A 1 372 ? 2.911   -14.085 -36.141 1.00 60.75  ? 635  LEU   A CB  1 
ATOM   2646 C  CG  . LEU   A 1 372 ? 2.719   -15.539 -36.542 1.00 62.43  ? 635  LEU   A CG  1 
ATOM   2647 C  CD1 . LEU   A 1 372 ? 3.414   -16.450 -35.552 1.00 64.56  ? 635  LEU   A CD1 1 
ATOM   2648 C  CD2 . LEU   A 1 372 ? 1.240   -15.867 -36.636 1.00 64.31  ? 635  LEU   A CD2 1 
ATOM   2649 N  N   . THR   A 1 373 ? 5.238   -12.506 -38.024 1.00 67.57  ? 636  THR   A N   1 
ATOM   2650 C  CA  . THR   A 1 373 ? 5.430   -11.438 -39.017 1.00 64.73  ? 636  THR   A CA  1 
ATOM   2651 C  C   . THR   A 1 373 ? 4.147   -11.398 -39.833 1.00 71.12  ? 636  THR   A C   1 
ATOM   2652 O  O   . THR   A 1 373 ? 3.286   -12.283 -39.617 1.00 70.79  ? 636  THR   A O   1 
ATOM   2653 C  CB  . THR   A 1 373 ? 6.715   -11.706 -39.797 1.00 60.15  ? 636  THR   A CB  1 
ATOM   2654 O  OG1 . THR   A 1 373 ? 6.432   -12.733 -40.745 1.00 64.99  ? 636  THR   A OG1 1 
ATOM   2655 C  CG2 . THR   A 1 373 ? 7.862   -12.102 -38.891 1.00 58.41  ? 636  THR   A CG2 1 
ATOM   2656 N  N   . VAL   A 1 374 ? 4.026   -10.418 -40.717 1.00 64.74  ? 637  VAL   A N   1 
ATOM   2657 C  CA  . VAL   A 1 374 ? 2.794   -10.191 -41.520 1.00 69.40  ? 637  VAL   A CA  1 
ATOM   2658 C  C   . VAL   A 1 374 ? 2.619   -11.396 -42.453 1.00 73.31  ? 637  VAL   A C   1 
ATOM   2659 O  O   . VAL   A 1 374 ? 1.466   -11.883 -42.614 1.00 66.23  ? 637  VAL   A O   1 
ATOM   2660 C  CB  . VAL   A 1 374 ? 2.873   -8.853  -42.292 1.00 78.61  ? 637  VAL   A CB  1 
ATOM   2661 C  CG1 . VAL   A 1 374 ? 3.101   -7.682  -41.349 1.00 78.58  ? 637  VAL   A CG1 1 
ATOM   2662 C  CG2 . VAL   A 1 374 ? 3.935   -8.849  -43.392 1.00 76.56  ? 637  VAL   A CG2 1 
ATOM   2663 N  N   . THR   A 1 375 ? 3.723   -11.865 -43.044 1.00 60.63  ? 638  THR   A N   1 
ATOM   2664 C  CA  . THR   A 1 375 ? 3.715   -12.925 -44.082 1.00 64.16  ? 638  THR   A CA  1 
ATOM   2665 C  C   . THR   A 1 375 ? 3.530   -14.301 -43.418 1.00 57.03  ? 638  THR   A C   1 
ATOM   2666 O  O   . THR   A 1 375 ? 3.130   -15.224 -44.139 1.00 51.34  ? 638  THR   A O   1 
ATOM   2667 C  CB  . THR   A 1 375 ? 4.981   -12.882 -44.947 1.00 65.33  ? 638  THR   A CB  1 
ATOM   2668 O  OG1 . THR   A 1 375 ? 6.072   -13.191 -44.083 1.00 75.95  ? 638  THR   A OG1 1 
ATOM   2669 C  CG2 . THR   A 1 375 ? 5.202   -11.543 -45.625 1.00 70.64  ? 638  THR   A CG2 1 
ATOM   2670 N  N   . GLU   A 1 376 ? 3.888   -14.442 -42.134 1.00 57.70  ? 639  GLU   A N   1 
ATOM   2671 C  CA  . GLU   A 1 376 ? 3.673   -15.699 -41.364 1.00 64.25  ? 639  GLU   A CA  1 
ATOM   2672 C  C   . GLU   A 1 376 ? 2.176   -15.809 -41.088 1.00 59.31  ? 639  GLU   A C   1 
ATOM   2673 O  O   . GLU   A 1 376 ? 1.638   -16.885 -41.360 1.00 54.18  ? 639  GLU   A O   1 
ATOM   2674 C  CB  . GLU   A 1 376 ? 4.528   -15.771 -40.100 1.00 57.85  ? 639  GLU   A CB  1 
ATOM   2675 C  CG  . GLU   A 1 376 ? 5.914   -16.344 -40.370 1.00 55.37  ? 639  GLU   A CG  1 
ATOM   2676 C  CD  . GLU   A 1 376 ? 6.877   -16.290 -39.194 1.00 50.65  ? 639  GLU   A CD  1 
ATOM   2677 O  OE1 . GLU   A 1 376 ? 7.793   -17.130 -39.148 1.00 58.24  ? 639  GLU   A OE1 1 
ATOM   2678 O  OE2 . GLU   A 1 376 ? 6.721   -15.403 -38.323 1.00 59.70  ? 639  GLU   A OE2 1 
ATOM   2679 N  N   . GLU   A 1 377 ? 1.525   -14.707 -40.697 1.00 58.76  ? 640  GLU   A N   1 
ATOM   2680 C  CA  . GLU   A 1 377 ? 0.048   -14.658 -40.524 1.00 54.89  ? 640  GLU   A CA  1 
ATOM   2681 C  C   . GLU   A 1 377 ? -0.634  -15.215 -41.768 1.00 55.04  ? 640  GLU   A C   1 
ATOM   2682 O  O   . GLU   A 1 377 ? -1.500  -16.071 -41.644 1.00 58.72  ? 640  GLU   A O   1 
ATOM   2683 C  CB  . GLU   A 1 377 ? -0.451  -13.246 -40.268 1.00 54.88  ? 640  GLU   A CB  1 
ATOM   2684 C  CG  . GLU   A 1 377 ? -0.083  -12.749 -38.897 1.00 62.46  ? 640  GLU   A CG  1 
ATOM   2685 C  CD  . GLU   A 1 377 ? -0.884  -11.533 -38.473 1.00 71.09  ? 640  GLU   A CD  1 
ATOM   2686 O  OE1 . GLU   A 1 377 ? -2.095  -11.475 -38.827 1.00 77.05  ? 640  GLU   A OE1 1 
ATOM   2687 O  OE2 . GLU   A 1 377 ? -0.304  -10.662 -37.776 1.00 70.82  ? 640  GLU   A OE2 1 
ATOM   2688 N  N   . ILE   A 1 378 ? -0.235  -14.769 -42.944 1.00 58.75  ? 641  ILE   A N   1 
ATOM   2689 C  CA  . ILE   A 1 378 ? -0.890  -15.188 -44.218 1.00 55.75  ? 641  ILE   A CA  1 
ATOM   2690 C  C   . ILE   A 1 378 ? -0.540  -16.664 -44.492 1.00 53.58  ? 641  ILE   A C   1 
ATOM   2691 O  O   . ILE   A 1 378 ? -1.359  -17.393 -45.084 1.00 50.79  ? 641  ILE   A O   1 
ATOM   2692 C  CB  . ILE   A 1 378 ? -0.506  -14.202 -45.357 1.00 57.81  ? 641  ILE   A CB  1 
ATOM   2693 C  CG1 . ILE   A 1 378 ? -1.001  -14.615 -46.745 1.00 58.04  ? 641  ILE   A CG1 1 
ATOM   2694 C  CG2 . ILE   A 1 378 ? 0.985   -13.948 -45.374 1.00 61.18  ? 641  ILE   A CG2 1 
ATOM   2695 C  CD1 . ILE   A 1 378 ? 0.052   -15.268 -47.617 1.00 62.29  ? 641  ILE   A CD1 1 
ATOM   2696 N  N   . ALA   A 1 379 ? 0.672   -17.094 -44.152 1.00 49.67  ? 642  ALA   A N   1 
ATOM   2697 C  CA  . ALA   A 1 379 ? 1.102   -18.503 -44.312 1.00 47.19  ? 642  ALA   A CA  1 
ATOM   2698 C  C   . ALA   A 1 379 ? 0.227   -19.424 -43.418 1.00 36.74  ? 642  ALA   A C   1 
ATOM   2699 O  O   . ALA   A 1 379 ? -0.241  -20.448 -43.904 1.00 39.30  ? 642  ALA   A O   1 
ATOM   2700 C  CB  . ALA   A 1 379 ? 2.574   -18.595 -43.979 1.00 46.16  ? 642  ALA   A CB  1 
ATOM   2701 N  N   . VAL   A 1 380 ? 0.009   -19.017 -42.172 1.00 37.32  ? 643  VAL   A N   1 
ATOM   2702 C  CA  . VAL   A 1 380 ? -0.822  -19.743 -41.175 1.00 44.52  ? 643  VAL   A CA  1 
ATOM   2703 C  C   . VAL   A 1 380 ? -2.251  -19.812 -41.717 1.00 46.18  ? 643  VAL   A C   1 
ATOM   2704 O  O   . VAL   A 1 380 ? -2.792  -20.934 -41.796 1.00 38.28  ? 643  VAL   A O   1 
ATOM   2705 C  CB  . VAL   A 1 380 ? -0.742  -19.104 -39.782 1.00 42.26  ? 643  VAL   A CB  1 
ATOM   2706 C  CG1 . VAL   A 1 380 ? -1.814  -19.667 -38.857 1.00 44.99  ? 643  VAL   A CG1 1 
ATOM   2707 C  CG2 . VAL   A 1 380 ? 0.627   -19.312 -39.149 1.00 44.32  ? 643  VAL   A CG2 1 
ATOM   2708 N  N   . LYS   A 1 381 ? -2.821  -18.695 -42.156 1.00 44.45  ? 644  LYS   A N   1 
ATOM   2709 C  CA  . LYS   A 1 381 ? -4.210  -18.709 -42.671 1.00 45.64  ? 644  LYS   A CA  1 
ATOM   2710 C  C   . LYS   A 1 381 ? -4.276  -19.611 -43.908 1.00 44.71  ? 644  LYS   A C   1 
ATOM   2711 O  O   . LYS   A 1 381 ? -5.241  -20.370 -44.030 1.00 40.20  ? 644  LYS   A O   1 
ATOM   2712 C  CB  . LYS   A 1 381 ? -4.667  -17.280 -42.977 1.00 58.17  ? 644  LYS   A CB  1 
ATOM   2713 C  CG  . LYS   A 1 381 ? -4.795  -16.361 -41.772 1.00 63.83  ? 644  LYS   A CG  1 
ATOM   2714 C  CD  . LYS   A 1 381 ? -5.287  -14.974 -42.122 1.00 75.59  ? 644  LYS   A CD  1 
ATOM   2715 C  CE  . LYS   A 1 381 ? -5.380  -14.055 -40.923 1.00 78.49  ? 644  LYS   A CE  1 
ATOM   2716 N  NZ  . LYS   A 1 381 ? -4.045  -13.739 -40.363 1.00 78.54  ? 644  LYS   A NZ  1 
ATOM   2717 N  N   . ASN   A 1 382 ? -3.267  -19.535 -44.771 1.00 42.36  ? 645  ASN   A N   1 
ATOM   2718 C  CA  . ASN   A 1 382 ? -3.233  -20.325 -46.032 1.00 44.47  ? 645  ASN   A CA  1 
ATOM   2719 C  C   . ASN   A 1 382 ? -3.081  -21.811 -45.727 1.00 38.70  ? 645  ASN   A C   1 
ATOM   2720 O  O   . ASN   A 1 382 ? -3.728  -22.623 -46.421 1.00 39.23  ? 645  ASN   A O   1 
ATOM   2721 C  CB  . ASN   A 1 382 ? -2.104  -19.883 -46.969 1.00 53.74  ? 645  ASN   A CB  1 
ATOM   2722 C  CG  . ASN   A 1 382 ? -2.567  -18.752 -47.862 1.00 66.85  ? 645  ASN   A CG  1 
ATOM   2723 O  OD1 . ASN   A 1 382 ? -2.088  -17.623 -47.757 1.00 72.91  ? 645  ASN   A OD1 1 
ATOM   2724 N  ND2 . ASN   A 1 382 ? -3.550  -19.044 -48.699 1.00 72.15  ? 645  ASN   A ND2 1 
ATOM   2725 N  N   . TRP   A 1 383 ? -2.225  -22.156 -44.751 1.00 38.70  ? 646  TRP   A N   1 
ATOM   2726 C  CA  . TRP   A 1 383 ? -2.103  -23.568 -44.278 1.00 37.64  ? 646  TRP   A CA  1 
ATOM   2727 C  C   . TRP   A 1 383 ? -3.516  -24.079 -43.887 1.00 30.13  ? 646  TRP   A C   1 
ATOM   2728 O  O   . TRP   A 1 383 ? -4.013  -25.105 -44.440 1.00 32.97  ? 646  TRP   A O   1 
ATOM   2729 C  CB  . TRP   A 1 383 ? -1.082  -23.601 -43.136 1.00 32.85  ? 646  TRP   A CB  1 
ATOM   2730 C  CG  . TRP   A 1 383 ? -0.664  -24.961 -42.676 1.00 40.98  ? 646  TRP   A CG  1 
ATOM   2731 C  CD1 . TRP   A 1 383 ? 0.345   -25.755 -43.163 1.00 41.21  ? 646  TRP   A CD1 1 
ATOM   2732 C  CD2 . TRP   A 1 383 ? -1.250  -25.692 -41.588 1.00 36.63  ? 646  TRP   A CD2 1 
ATOM   2733 N  NE1 . TRP   A 1 383 ? 0.423   -26.930 -42.453 1.00 37.28  ? 646  TRP   A NE1 1 
ATOM   2734 C  CE2 . TRP   A 1 383 ? -0.520  -26.901 -41.459 1.00 38.06  ? 646  TRP   A CE2 1 
ATOM   2735 C  CE3 . TRP   A 1 383 ? -2.302  -25.428 -40.713 1.00 35.33  ? 646  TRP   A CE3 1 
ATOM   2736 C  CZ2 . TRP   A 1 383 ? -0.815  -27.833 -40.462 1.00 33.92  ? 646  TRP   A CZ2 1 
ATOM   2737 C  CZ3 . TRP   A 1 383 ? -2.599  -26.349 -39.730 1.00 35.66  ? 646  TRP   A CZ3 1 
ATOM   2738 C  CH2 . TRP   A 1 383 ? -1.868  -27.535 -39.613 1.00 34.28  ? 646  TRP   A CH2 1 
ATOM   2739 N  N   . LEU   A 1 384 ? -4.203  -23.314 -43.046 1.00 34.16  ? 647  LEU   A N   1 
ATOM   2740 C  CA  . LEU   A 1 384 ? -5.549  -23.696 -42.533 1.00 40.53  ? 647  LEU   A CA  1 
ATOM   2741 C  C   . LEU   A 1 384 ? -6.532  -23.905 -43.698 1.00 39.22  ? 647  LEU   A C   1 
ATOM   2742 O  O   . LEU   A 1 384 ? -7.154  -24.980 -43.756 1.00 37.83  ? 647  LEU   A O   1 
ATOM   2743 C  CB  . LEU   A 1 384 ? -6.026  -22.642 -41.533 1.00 36.72  ? 647  LEU   A CB  1 
ATOM   2744 C  CG  . LEU   A 1 384 ? -5.320  -22.667 -40.181 1.00 36.65  ? 647  LEU   A CG  1 
ATOM   2745 C  CD1 . LEU   A 1 384 ? -5.761  -21.485 -39.341 1.00 38.01  ? 647  LEU   A CD1 1 
ATOM   2746 C  CD2 . LEU   A 1 384 ? -5.573  -23.964 -39.408 1.00 35.73  ? 647  LEU   A CD2 1 
ATOM   2747 N  N   . VAL   A 1 385 ? -6.631  -22.959 -44.633 1.00 41.37  ? 648  VAL   A N   1 
ATOM   2748 C  CA  . VAL   A 1 385 ? -7.555  -23.048 -45.802 1.00 38.83  ? 648  VAL   A CA  1 
ATOM   2749 C  C   . VAL   A 1 385 ? -7.117  -24.223 -46.664 1.00 37.79  ? 648  VAL   A C   1 
ATOM   2750 O  O   . VAL   A 1 385 ? -7.971  -25.001 -47.094 1.00 45.83  ? 648  VAL   A O   1 
ATOM   2751 C  CB  . VAL   A 1 385 ? -7.584  -21.730 -46.615 1.00 48.98  ? 648  VAL   A CB  1 
ATOM   2752 C  CG1 . VAL   A 1 385 ? -8.434  -21.859 -47.863 1.00 47.96  ? 648  VAL   A CG1 1 
ATOM   2753 C  CG2 . VAL   A 1 385 ? -8.075  -20.556 -45.775 1.00 52.71  ? 648  VAL   A CG2 1 
ATOM   2754 N  N   . ARG   A 1 386 ? -5.824  -24.386 -46.898 1.00 38.68  ? 649  ARG   A N   1 
ATOM   2755 C  CA  . ARG   A 1 386 ? -5.342  -25.441 -47.830 1.00 39.43  ? 649  ARG   A CA  1 
ATOM   2756 C  C   . ARG   A 1 386 ? -5.419  -26.837 -47.187 1.00 42.30  ? 649  ARG   A C   1 
ATOM   2757 O  O   . ARG   A 1 386 ? -5.905  -27.773 -47.884 1.00 38.80  ? 649  ARG   A O   1 
ATOM   2758 C  CB  . ARG   A 1 386 ? -3.920  -25.071 -48.267 1.00 53.01  ? 649  ARG   A CB  1 
ATOM   2759 C  CG  . ARG   A 1 386 ? -3.233  -26.062 -49.206 1.00 62.21  ? 649  ARG   A CG  1 
ATOM   2760 C  CD  . ARG   A 1 386 ? -1.802  -25.677 -49.649 1.00 66.84  ? 649  ARG   A CD  1 
ATOM   2761 N  NE  . ARG   A 1 386 ? -0.705  -25.850 -48.670 1.00 64.70  ? 649  ARG   A NE  1 
ATOM   2762 C  CZ  . ARG   A 1 386 ? -0.225  -24.903 -47.840 1.00 61.82  ? 649  ARG   A CZ  1 
ATOM   2763 N  NH1 . ARG   A 1 386 ? -0.738  -23.680 -47.816 1.00 67.67  ? 649  ARG   A NH1 1 
ATOM   2764 N  NH2 . ARG   A 1 386 ? 0.789   -25.179 -47.041 1.00 56.24  ? 649  ARG   A NH2 1 
ATOM   2765 N  N   . VAL   A 1 387 ? -4.932  -27.023 -45.944 1.00 39.09  ? 650  VAL   A N   1 
ATOM   2766 C  CA  . VAL   A 1 387 ? -4.782  -28.418 -45.421 1.00 40.81  ? 650  VAL   A CA  1 
ATOM   2767 C  C   . VAL   A 1 387 ? -5.467  -28.622 -44.049 1.00 38.57  ? 650  VAL   A C   1 
ATOM   2768 O  O   . VAL   A 1 387 ? -5.375  -29.758 -43.570 1.00 35.31  ? 650  VAL   A O   1 
ATOM   2769 C  CB  . VAL   A 1 387 ? -3.299  -28.846 -45.347 1.00 35.30  ? 650  VAL   A CB  1 
ATOM   2770 C  CG1 . VAL   A 1 387 ? -2.631  -28.818 -46.704 1.00 39.42  ? 650  VAL   A CG1 1 
ATOM   2771 C  CG2 . VAL   A 1 387 ? -2.530  -28.028 -44.319 1.00 35.93  ? 650  VAL   A CG2 1 
ATOM   2772 N  N   . GLY   A 1 388 ? -6.051  -27.575 -43.450 1.00 32.75  ? 651  GLY   A N   1 
ATOM   2773 C  CA  . GLY   A 1 388 ? -6.680  -27.569 -42.108 1.00 34.46  ? 651  GLY   A CA  1 
ATOM   2774 C  C   . GLY   A 1 388 ? -7.590  -28.773 -41.900 1.00 34.31  ? 651  GLY   A C   1 
ATOM   2775 O  O   . GLY   A 1 388 ? -7.418  -29.504 -40.920 1.00 33.23  ? 651  GLY   A O   1 
ATOM   2776 N  N   . ARG   A 1 389 ? -8.476  -29.041 -42.839 1.00 32.10  ? 652  ARG   A N   1 
ATOM   2777 C  CA  . ARG   A 1 389 ? -9.473  -30.129 -42.680 1.00 34.86  ? 652  ARG   A CA  1 
ATOM   2778 C  C   . ARG   A 1 389 ? -8.730  -31.468 -42.733 1.00 33.97  ? 652  ARG   A C   1 
ATOM   2779 O  O   . ARG   A 1 389 ? -9.105  -32.388 -41.950 1.00 30.25  ? 652  ARG   A O   1 
ATOM   2780 C  CB  . ARG   A 1 389 ? -10.583 -30.007 -43.733 1.00 35.28  ? 652  ARG   A CB  1 
ATOM   2781 C  CG  . ARG   A 1 389 ? -11.554 -28.868 -43.463 1.00 37.02  ? 652  ARG   A CG  1 
ATOM   2782 C  CD  . ARG   A 1 389 ? -12.626 -28.874 -44.553 1.00 40.01  ? 652  ARG   A CD  1 
ATOM   2783 N  NE  . ARG   A 1 389 ? -13.542 -29.998 -44.494 1.00 42.99  ? 652  ARG   A NE  1 
ATOM   2784 C  CZ  . ARG   A 1 389 ? -14.616 -30.089 -43.680 1.00 41.76  ? 652  ARG   A CZ  1 
ATOM   2785 N  NH1 . ARG   A 1 389 ? -14.940 -29.127 -42.826 1.00 42.74  ? 652  ARG   A NH1 1 
ATOM   2786 N  NH2 . ARG   A 1 389 ? -15.360 -31.170 -43.732 1.00 42.64  ? 652  ARG   A NH2 1 
ATOM   2787 N  N   . GLU   A 1 390 ? -7.696  -31.601 -43.578 1.00 29.22  ? 653  GLU   A N   1 
ATOM   2788 C  CA  . GLU   A 1 390 ? -6.913  -32.876 -43.626 1.00 34.02  ? 653  GLU   A CA  1 
ATOM   2789 C  C   . GLU   A 1 390 ? -6.229  -33.104 -42.257 1.00 28.99  ? 653  GLU   A C   1 
ATOM   2790 O  O   . GLU   A 1 390 ? -6.270  -34.300 -41.738 1.00 28.84  ? 653  GLU   A O   1 
ATOM   2791 C  CB  . GLU   A 1 390 ? -5.923  -32.912 -44.806 1.00 33.71  ? 653  GLU   A CB  1 
ATOM   2792 C  CG  . GLU   A 1 390 ? -5.381  -34.292 -45.130 1.00 33.06  ? 653  GLU   A CG  1 
ATOM   2793 C  CD  . GLU   A 1 390 ? -4.214  -34.783 -44.271 1.00 39.15  ? 653  GLU   A CD  1 
ATOM   2794 O  OE1 . GLU   A 1 390 ? -3.636  -33.992 -43.502 1.00 38.96  ? 653  GLU   A OE1 1 
ATOM   2795 O  OE2 . GLU   A 1 390 ? -3.879  -35.968 -44.348 1.00 42.50  ? 653  GLU   A OE2 1 
ATOM   2796 N  N   . ARG   A 1 391 ? -5.726  -32.027 -41.665 1.00 28.41  ? 654  ARG   A N   1 
ATOM   2797 C  CA  . ARG   A 1 391 ? -4.916  -32.079 -40.427 1.00 31.46  ? 654  ARG   A CA  1 
ATOM   2798 C  C   . ARG   A 1 391 ? -5.861  -32.412 -39.258 1.00 31.08  ? 654  ARG   A C   1 
ATOM   2799 O  O   . ARG   A 1 391 ? -5.394  -33.094 -38.294 1.00 25.80  ? 654  ARG   A O   1 
ATOM   2800 C  CB  . ARG   A 1 391 ? -4.124  -30.777 -40.238 1.00 31.10  ? 654  ARG   A CB  1 
ATOM   2801 C  CG  . ARG   A 1 391 ? -3.037  -30.513 -41.286 1.00 30.75  ? 654  ARG   A CG  1 
ATOM   2802 C  CD  . ARG   A 1 391 ? -2.053  -31.657 -41.469 1.00 34.55  ? 654  ARG   A CD  1 
ATOM   2803 N  NE  . ARG   A 1 391 ? -0.923  -31.242 -42.266 1.00 35.86  ? 654  ARG   A NE  1 
ATOM   2804 C  CZ  . ARG   A 1 391 ? -0.839  -31.398 -43.586 1.00 41.43  ? 654  ARG   A CZ  1 
ATOM   2805 N  NH1 . ARG   A 1 391 ? -1.759  -32.047 -44.279 1.00 41.64  ? 654  ARG   A NH1 1 
ATOM   2806 N  NH2 . ARG   A 1 391 ? 0.204   -30.924 -44.226 1.00 49.44  ? 654  ARG   A NH2 1 
ATOM   2807 N  N   . LEU   A 1 392 ? -7.127  -31.970 -39.322 1.00 26.74  ? 655  LEU   A N   1 
ATOM   2808 C  CA  . LEU   A 1 392 ? -8.153  -32.266 -38.264 1.00 26.78  ? 655  LEU   A CA  1 
ATOM   2809 C  C   . LEU   A 1 392 ? -8.466  -33.767 -38.303 1.00 26.18  ? 655  LEU   A C   1 
ATOM   2810 O  O   . LEU   A 1 392 ? -8.617  -34.380 -37.235 1.00 27.49  ? 655  LEU   A O   1 
ATOM   2811 C  CB  . LEU   A 1 392 ? -9.441  -31.469 -38.482 1.00 31.01  ? 655  LEU   A CB  1 
ATOM   2812 C  CG  . LEU   A 1 392 ? -9.401  -29.987 -38.138 1.00 27.93  ? 655  LEU   A CG  1 
ATOM   2813 C  CD1 . LEU   A 1 392 ? -10.746 -29.377 -38.512 1.00 27.92  ? 655  LEU   A CD1 1 
ATOM   2814 C  CD2 . LEU   A 1 392 ? -9.054  -29.744 -36.652 1.00 28.15  ? 655  LEU   A CD2 1 
ATOM   2815 N  N   . SER   A 1 393 ? -8.498  -34.345 -39.490 1.00 28.42  ? 656  SER   A N   1 
ATOM   2816 C  CA  . SER   A 1 393 ? -8.817  -35.774 -39.689 1.00 28.43  ? 656  SER   A CA  1 
ATOM   2817 C  C   . SER   A 1 393 ? -7.684  -36.688 -39.206 1.00 26.61  ? 656  SER   A C   1 
ATOM   2818 O  O   . SER   A 1 393 ? -7.906  -37.880 -39.138 1.00 25.92  ? 656  SER   A O   1 
ATOM   2819 C  CB  . SER   A 1 393 ? -9.248  -36.070 -41.131 1.00 31.26  ? 656  SER   A CB  1 
ATOM   2820 O  OG  . SER   A 1 393 ? -8.119  -36.132 -42.037 1.00 35.19  ? 656  SER   A OG  1 
ATOM   2821 N  N   . ARG   A 1 394 ? -6.500  -36.131 -38.922 0.28 25.97  ? 657  ARG   A N   1 
ATOM   2822 C  CA  . ARG   A 1 394 ? -5.324  -36.881 -38.405 0.28 25.72  ? 657  ARG   A CA  1 
ATOM   2823 C  C   . ARG   A 1 394 ? -5.409  -36.981 -36.880 0.28 25.12  ? 657  ARG   A C   1 
ATOM   2824 O  O   . ARG   A 1 394 ? -4.433  -37.467 -36.272 0.28 25.14  ? 657  ARG   A O   1 
ATOM   2825 C  CB  . ARG   A 1 394 ? -4.019  -36.183 -38.796 0.28 26.92  ? 657  ARG   A CB  1 
ATOM   2826 C  CG  . ARG   A 1 394 ? -3.646  -36.317 -40.264 0.28 27.64  ? 657  ARG   A CG  1 
ATOM   2827 C  CD  . ARG   A 1 394 ? -2.431  -35.467 -40.587 0.28 28.39  ? 657  ARG   A CD  1 
ATOM   2828 N  NE  . ARG   A 1 394 ? -1.892  -35.802 -41.891 0.28 28.04  ? 657  ARG   A NE  1 
ATOM   2829 C  CZ  . ARG   A 1 394 ? -1.064  -36.805 -42.124 0.28 28.93  ? 657  ARG   A CZ  1 
ATOM   2830 N  NH1 . ARG   A 1 394 ? -0.653  -37.571 -41.128 0.28 28.75  ? 657  ARG   A NH1 1 
ATOM   2831 N  NH2 . ARG   A 1 394 ? -0.641  -37.031 -43.355 0.28 29.40  ? 657  ARG   A NH2 1 
ATOM   2832 N  N   . MET   A 1 395 ? -6.519  -36.528 -36.288 1.00 24.00  ? 658  MET   A N   1 
ATOM   2833 C  CA  . MET   A 1 395 ? -6.684  -36.494 -34.817 1.00 23.73  ? 658  MET   A CA  1 
ATOM   2834 C  C   . MET   A 1 395 ? -7.988  -37.158 -34.348 1.00 25.59  ? 658  MET   A C   1 
ATOM   2835 O  O   . MET   A 1 395 ? -8.992  -37.176 -35.066 1.00 21.81  ? 658  MET   A O   1 
ATOM   2836 C  CB  . MET   A 1 395 ? -6.617  -35.033 -34.373 1.00 24.85  ? 658  MET   A CB  1 
ATOM   2837 C  CG  . MET   A 1 395 ? -5.374  -34.309 -34.888 1.00 27.32  ? 658  MET   A CG  1 
ATOM   2838 S  SD  . MET   A 1 395 ? -5.006  -32.776 -34.075 1.00 27.73  ? 658  MET   A SD  1 
ATOM   2839 C  CE  . MET   A 1 395 ? -6.325  -31.707 -34.673 1.00 26.38  ? 658  MET   A CE  1 
ATOM   2840 N  N   . ALA   A 1 396 ? -7.949  -37.656 -33.109 1.00 23.38  ? 659  ALA   A N   1 
ATOM   2841 C  CA  . ALA   A 1 396 ? -9.112  -38.100 -32.352 1.00 23.87  ? 659  ALA   A CA  1 
ATOM   2842 C  C   . ALA   A 1 396 ? -9.033  -37.376 -31.022 1.00 23.67  ? 659  ALA   A C   1 
ATOM   2843 O  O   . ALA   A 1 396 ? -8.067  -37.543 -30.297 1.00 21.59  ? 659  ALA   A O   1 
ATOM   2844 C  CB  . ALA   A 1 396 ? -9.137  -39.617 -32.209 1.00 24.09  ? 659  ALA   A CB  1 
ATOM   2845 N  N   . ILE   A 1 397 ? -10.002 -36.498 -30.796 1.00 23.13  ? 660  ILE   A N   1 
ATOM   2846 C  CA  . ILE   A 1 397 ? -10.007 -35.611 -29.628 1.00 22.24  ? 660  ILE   A CA  1 
ATOM   2847 C  C   . ILE   A 1 397 ? -11.329 -35.724 -28.860 1.00 25.04  ? 660  ILE   A C   1 
ATOM   2848 O  O   . ILE   A 1 397 ? -12.384 -35.489 -29.404 1.00 22.12  ? 660  ILE   A O   1 
ATOM   2849 C  CB  . ILE   A 1 397 ? -9.687  -34.206 -30.089 1.00 24.75  ? 660  ILE   A CB  1 
ATOM   2850 C  CG1 . ILE   A 1 397 ? -8.346  -34.180 -30.829 1.00 27.23  ? 660  ILE   A CG1 1 
ATOM   2851 C  CG2 . ILE   A 1 397 ? -9.747  -33.311 -28.883 1.00 23.63  ? 660  ILE   A CG2 1 
ATOM   2852 C  CD1 . ILE   A 1 397 ? -7.757  -32.812 -31.095 1.00 28.97  ? 660  ILE   A CD1 1 
ATOM   2853 N  N   . SER   A 1 398 ? -11.211 -36.003 -27.574 1.00 24.35  ? 661  SER   A N   1 
ATOM   2854 C  CA  . SER   A 1 398 ? -12.315 -36.182 -26.611 1.00 26.62  ? 661  SER   A CA  1 
ATOM   2855 C  C   . SER   A 1 398 ? -12.010 -35.305 -25.413 1.00 27.51  ? 661  SER   A C   1 
ATOM   2856 O  O   . SER   A 1 398 ? -11.192 -35.723 -24.596 1.00 24.75  ? 661  SER   A O   1 
ATOM   2857 C  CB  . SER   A 1 398 ? -12.514 -37.632 -26.228 1.00 28.36  ? 661  SER   A CB  1 
ATOM   2858 O  OG  . SER   A 1 398 ? -13.727 -37.760 -25.504 1.00 29.65  ? 661  SER   A OG  1 
ATOM   2859 N  N   . GLY   A 1 399 ? -12.494 -34.056 -25.433 1.00 25.67  ? 662  GLY   A N   1 
ATOM   2860 C  CA  . GLY   A 1 399 ? -12.089 -33.102 -24.393 1.00 26.44  ? 662  GLY   A CA  1 
ATOM   2861 C  C   . GLY   A 1 399 ? -10.586 -32.956 -24.285 1.00 26.17  ? 662  GLY   A C   1 
ATOM   2862 O  O   . GLY   A 1 399 ? -9.924  -32.603 -25.304 1.00 27.07  ? 662  GLY   A O   1 
ATOM   2863 N  N   . ASP   A 1 400 ? -10.018 -33.118 -23.092 1.00 26.08  ? 663  ASP   A N   1 
ATOM   2864 C  CA  . ASP   A 1 400 ? -8.552  -32.948 -22.894 1.00 28.90  ? 663  ASP   A CA  1 
ATOM   2865 C  C   . ASP   A 1 400 ? -7.767  -34.160 -23.401 1.00 30.55  ? 663  ASP   A C   1 
ATOM   2866 O  O   . ASP   A 1 400 ? -6.539  -34.117 -23.380 1.00 28.39  ? 663  ASP   A O   1 
ATOM   2867 C  CB  . ASP   A 1 400 ? -8.224  -32.719 -21.420 1.00 34.74  ? 663  ASP   A CB  1 
ATOM   2868 C  CG  . ASP   A 1 400 ? -8.558  -33.857 -20.467 1.00 40.20  ? 663  ASP   A CG  1 
ATOM   2869 O  OD1 . ASP   A 1 400 ? -9.209  -34.824 -20.854 1.00 39.08  ? 663  ASP   A OD1 1 
ATOM   2870 O  OD2 . ASP   A 1 400 ? -8.143  -33.762 -19.318 1.00 45.90  ? 663  ASP   A OD2 1 
ATOM   2871 N  N   . ASP   A 1 401 ? -8.425  -35.172 -23.937 1.00 27.10  ? 664  ASP   A N   1 
ATOM   2872 C  CA  . ASP   A 1 401 ? -7.747  -36.408 -24.386 1.00 26.90  ? 664  ASP   A CA  1 
ATOM   2873 C  C   . ASP   A 1 401 ? -7.531  -36.395 -25.899 1.00 26.02  ? 664  ASP   A C   1 
ATOM   2874 O  O   . ASP   A 1 401 ? -8.486  -36.067 -26.621 1.00 29.82  ? 664  ASP   A O   1 
ATOM   2875 C  CB  . ASP   A 1 401 ? -8.589  -37.622 -23.969 1.00 28.38  ? 664  ASP   A CB  1 
ATOM   2876 C  CG  . ASP   A 1 401 ? -7.705  -38.842 -23.831 1.00 36.49  ? 664  ASP   A CG  1 
ATOM   2877 O  OD1 . ASP   A 1 401 ? -6.534  -38.659 -24.082 1.00 37.02  ? 664  ASP   A OD1 1 
ATOM   2878 O  OD2 . ASP   A 1 401 ? -8.198  -39.937 -23.530 1.00 36.54  ? 664  ASP   A OD2 1 
ATOM   2879 N  N   . CYS   A 1 402 ? -6.311  -36.643 -26.389 1.00 21.98  ? 665  CYS   A N   1 
ATOM   2880 C  CA  . CYS   A 1 402 ? -6.048  -36.609 -27.847 1.00 23.40  ? 665  CYS   A CA  1 
ATOM   2881 C  C   . CYS   A 1 402 ? -5.152  -37.745 -28.296 1.00 25.97  ? 665  CYS   A C   1 
ATOM   2882 O  O   . CYS   A 1 402 ? -4.285  -38.183 -27.534 1.00 28.03  ? 665  CYS   A O   1 
ATOM   2883 C  CB  . CYS   A 1 402 ? -5.428  -35.296 -28.325 1.00 30.13  ? 665  CYS   A CB  1 
ATOM   2884 S  SG  . CYS   A 1 402 ? -3.828  -34.930 -27.555 1.00 38.15  ? 665  CYS   A SG  1 
ATOM   2885 N  N   . VAL   A 1 403 ? -5.303  -38.057 -29.573 1.00 24.73  ? 666  VAL   A N   1 
ATOM   2886 C  CA  . VAL   A 1 403 ? -4.382  -38.878 -30.397 1.00 28.71  ? 666  VAL   A CA  1 
ATOM   2887 C  C   . VAL   A 1 403 ? -4.177  -38.099 -31.695 1.00 27.27  ? 666  VAL   A C   1 
ATOM   2888 O  O   . VAL   A 1 403 ? -5.170  -37.636 -32.249 1.00 24.18  ? 666  VAL   A O   1 
ATOM   2889 C  CB  . VAL   A 1 403 ? -4.950  -40.285 -30.616 1.00 24.99  ? 666  VAL   A CB  1 
ATOM   2890 C  CG1 . VAL   A 1 403 ? -4.109  -41.144 -31.540 1.00 28.56  ? 666  VAL   A CG1 1 
ATOM   2891 C  CG2 . VAL   A 1 403 ? -5.210  -40.960 -29.261 1.00 25.62  ? 666  VAL   A CG2 1 
ATOM   2892 N  N   . VAL   A 1 404 ? -2.929  -37.966 -32.101 1.00 25.08  ? 667  VAL   A N   1 
ATOM   2893 C  CA  . VAL   A 1 404 ? -2.520  -37.219 -33.310 1.00 24.54  ? 667  VAL   A CA  1 
ATOM   2894 C  C   . VAL   A 1 404 ? -1.555  -38.071 -34.104 1.00 22.14  ? 667  VAL   A C   1 
ATOM   2895 O  O   . VAL   A 1 404 ? -0.543  -38.539 -33.505 1.00 25.45  ? 667  VAL   A O   1 
ATOM   2896 C  CB  . VAL   A 1 404 ? -1.862  -35.874 -32.935 1.00 25.81  ? 667  VAL   A CB  1 
ATOM   2897 C  CG1 . VAL   A 1 404 ? -1.538  -35.080 -34.194 1.00 26.89  ? 667  VAL   A CG1 1 
ATOM   2898 C  CG2 . VAL   A 1 404 ? -2.739  -35.041 -32.027 1.00 29.89  ? 667  VAL   A CG2 1 
ATOM   2899 N  N   . LYS   A 1 405 ? -1.827  -38.248 -35.393 1.00 25.96  ? 668  LYS   A N   1 
ATOM   2900 C  CA  . LYS   A 1 405 ? -0.890  -38.844 -36.383 1.00 25.82  ? 668  LYS   A CA  1 
ATOM   2901 C  C   . LYS   A 1 405 ? -0.416  -37.733 -37.319 1.00 26.13  ? 668  LYS   A C   1 
ATOM   2902 O  O   . LYS   A 1 405 ? -1.016  -37.498 -38.385 1.00 25.66  ? 668  LYS   A O   1 
ATOM   2903 C  CB  . LYS   A 1 405 ? -1.480  -39.961 -37.224 1.00 27.19  ? 668  LYS   A CB  1 
ATOM   2904 C  CG  . LYS   A 1 405 ? -0.362  -40.697 -37.952 1.00 29.26  ? 668  LYS   A CG  1 
ATOM   2905 C  CD  . LYS   A 1 405 ? -0.647  -42.042 -38.534 1.00 32.10  ? 668  LYS   A CD  1 
ATOM   2906 C  CE  . LYS   A 1 405 ? 0.590   -42.446 -39.339 1.00 35.18  ? 668  LYS   A CE  1 
ATOM   2907 N  NZ  . LYS   A 1 405 ? 0.541   -43.852 -39.746 1.00 39.87  ? 668  LYS   A NZ  1 
ATOM   2908 N  N   . PRO   A 1 406 ? 0.662   -37.023 -36.931 1.00 26.26  ? 669  PRO   A N   1 
ATOM   2909 C  CA  . PRO   A 1 406 ? 1.164   -35.889 -37.721 1.00 26.35  ? 669  PRO   A CA  1 
ATOM   2910 C  C   . PRO   A 1 406 ? 1.800   -36.355 -39.030 1.00 27.12  ? 669  PRO   A C   1 
ATOM   2911 O  O   . PRO   A 1 406 ? 2.012   -37.547 -39.290 1.00 26.61  ? 669  PRO   A O   1 
ATOM   2912 C  CB  . PRO   A 1 406 ? 2.137   -35.211 -36.748 1.00 23.80  ? 669  PRO   A CB  1 
ATOM   2913 C  CG  . PRO   A 1 406 ? 2.714   -36.391 -35.982 1.00 25.99  ? 669  PRO   A CG  1 
ATOM   2914 C  CD  . PRO   A 1 406 ? 1.508   -37.288 -35.752 1.00 24.76  ? 669  PRO   A CD  1 
ATOM   2915 N  N   . LEU   A 1 407 ? 2.087   -35.378 -39.878 1.00 32.10  ? 670  LEU   A N   1 
ATOM   2916 C  CA  . LEU   A 1 407 ? 2.710   -35.604 -41.212 1.00 35.33  ? 670  LEU   A CA  1 
ATOM   2917 C  C   . LEU   A 1 407 ? 4.061   -36.335 -41.017 1.00 30.86  ? 670  LEU   A C   1 
ATOM   2918 O  O   . LEU   A 1 407 ? 4.383   -37.160 -41.848 1.00 33.62  ? 670  LEU   A O   1 
ATOM   2919 C  CB  . LEU   A 1 407 ? 2.847   -34.229 -41.886 1.00 35.92  ? 670  LEU   A CB  1 
ATOM   2920 C  CG  . LEU   A 1 407 ? 3.014   -34.200 -43.398 1.00 43.12  ? 670  LEU   A CG  1 
ATOM   2921 C  CD1 . LEU   A 1 407 ? 1.716   -34.532 -44.111 1.00 39.84  ? 670  LEU   A CD1 1 
ATOM   2922 C  CD2 . LEU   A 1 407 ? 3.513   -32.828 -43.822 1.00 44.84  ? 670  LEU   A CD2 1 
ATOM   2923 N  N   . ASP   A 1 408 ? 4.791   -36.093 -39.931 1.00 29.21  ? 671  ASP   A N   1 
ATOM   2924 C  CA  . ASP   A 1 408 ? 6.122   -36.734 -39.700 1.00 32.65  ? 671  ASP   A CA  1 
ATOM   2925 C  C   . ASP   A 1 408 ? 6.481   -36.565 -38.231 1.00 30.30  ? 671  ASP   A C   1 
ATOM   2926 O  O   . ASP   A 1 408 ? 5.738   -35.905 -37.520 1.00 37.47  ? 671  ASP   A O   1 
ATOM   2927 C  CB  . ASP   A 1 408 ? 7.170   -36.202 -40.718 1.00 34.82  ? 671  ASP   A CB  1 
ATOM   2928 C  CG  . ASP   A 1 408 ? 7.251   -34.683 -40.735 1.00 34.11  ? 671  ASP   A CG  1 
ATOM   2929 O  OD1 . ASP   A 1 408 ? 7.570   -34.129 -39.669 1.00 31.96  ? 671  ASP   A OD1 1 
ATOM   2930 O  OD2 . ASP   A 1 408 ? 6.872   -34.054 -41.765 1.00 36.70  ? 671  ASP   A OD2 1 
ATOM   2931 N  N   . ASP   A 1 409 ? 7.609   -37.111 -37.789 1.00 29.57  ? 672  ASP   A N   1 
ATOM   2932 C  CA  . ASP   A 1 409 ? 8.006   -37.082 -36.363 1.00 29.85  ? 672  ASP   A CA  1 
ATOM   2933 C  C   . ASP   A 1 409 ? 8.653   -35.755 -35.937 1.00 31.14  ? 672  ASP   A C   1 
ATOM   2934 O  O   . ASP   A 1 409 ? 8.979   -35.615 -34.732 1.00 32.45  ? 672  ASP   A O   1 
ATOM   2935 C  CB  . ASP   A 1 409 ? 8.805   -38.344 -36.081 1.00 34.35  ? 672  ASP   A CB  1 
ATOM   2936 C  CG  . ASP   A 1 409 ? 7.913   -39.572 -36.182 1.00 37.90  ? 672  ASP   A CG  1 
ATOM   2937 O  OD1 . ASP   A 1 409 ? 6.787   -39.531 -35.607 1.00 34.93  ? 672  ASP   A OD1 1 
ATOM   2938 O  OD2 . ASP   A 1 409 ? 8.338   -40.535 -36.843 1.00 36.56  ? 672  ASP   A OD2 1 
ATOM   2939 N  N   . ARG   A 1 410 ? 8.703   -34.730 -36.789 1.00 34.30  ? 673  ARG   A N   1 
ATOM   2940 C  CA  . ARG   A 1 410 ? 9.132   -33.380 -36.298 1.00 36.73  ? 673  ARG   A CA  1 
ATOM   2941 C  C   . ARG   A 1 410 ? 8.208   -32.900 -35.152 1.00 34.58  ? 673  ARG   A C   1 
ATOM   2942 O  O   . ARG   A 1 410 ? 8.654   -32.166 -34.263 1.00 28.89  ? 673  ARG   A O   1 
ATOM   2943 C  CB  . ARG   A 1 410 ? 9.123   -32.362 -37.441 1.00 39.97  ? 673  ARG   A CB  1 
ATOM   2944 C  CG  . ARG   A 1 410 ? 10.282  -32.476 -38.424 1.00 38.92  ? 673  ARG   A CG  1 
ATOM   2945 C  CD  . ARG   A 1 410 ? 10.125  -31.442 -39.523 1.00 35.04  ? 673  ARG   A CD  1 
ATOM   2946 N  NE  . ARG   A 1 410 ? 8.953   -31.749 -40.345 1.00 35.13  ? 673  ARG   A NE  1 
ATOM   2947 C  CZ  . ARG   A 1 410 ? 8.459   -30.977 -41.311 1.00 38.63  ? 673  ARG   A CZ  1 
ATOM   2948 N  NH1 . ARG   A 1 410 ? 9.026   -29.804 -41.585 1.00 33.75  ? 673  ARG   A NH1 1 
ATOM   2949 N  NH2 . ARG   A 1 410 ? 7.388   -31.382 -41.983 1.00 35.48  ? 673  ARG   A NH2 1 
ATOM   2950 N  N   . PHE   A 1 411 ? 6.923   -33.272 -35.189 1.00 32.32  ? 674  PHE   A N   1 
ATOM   2951 C  CA  . PHE   A 1 411 ? 5.893   -33.016 -34.151 1.00 26.68  ? 674  PHE   A CA  1 
ATOM   2952 C  C   . PHE   A 1 411 ? 6.405   -33.345 -32.746 1.00 24.95  ? 674  PHE   A C   1 
ATOM   2953 O  O   . PHE   A 1 411 ? 6.127   -32.586 -31.809 1.00 31.77  ? 674  PHE   A O   1 
ATOM   2954 C  CB  . PHE   A 1 411 ? 4.656   -33.881 -34.487 1.00 29.64  ? 674  PHE   A CB  1 
ATOM   2955 C  CG  . PHE   A 1 411 ? 3.480   -33.713 -33.558 1.00 28.60  ? 674  PHE   A CG  1 
ATOM   2956 C  CD1 . PHE   A 1 411 ? 3.340   -34.512 -32.436 1.00 26.90  ? 674  PHE   A CD1 1 
ATOM   2957 C  CD2 . PHE   A 1 411 ? 2.460   -32.825 -33.870 1.00 27.15  ? 674  PHE   A CD2 1 
ATOM   2958 C  CE1 . PHE   A 1 411 ? 2.222   -34.380 -31.613 1.00 29.20  ? 674  PHE   A CE1 1 
ATOM   2959 C  CE2 . PHE   A 1 411 ? 1.354   -32.677 -33.038 1.00 25.05  ? 674  PHE   A CE2 1 
ATOM   2960 C  CZ  . PHE   A 1 411 ? 1.221   -33.468 -31.917 1.00 26.21  ? 674  PHE   A CZ  1 
ATOM   2961 N  N   . ALA   A 1 412 ? 7.140   -34.457 -32.584 1.00 28.79  ? 675  ALA   A N   1 
ATOM   2962 C  CA  . ALA   A 1 412 ? 7.658   -34.969 -31.292 1.00 29.50  ? 675  ALA   A CA  1 
ATOM   2963 C  C   . ALA   A 1 412 ? 8.418   -33.881 -30.506 1.00 33.83  ? 675  ALA   A C   1 
ATOM   2964 O  O   . ALA   A 1 412 ? 8.274   -33.808 -29.245 1.00 26.96  ? 675  ALA   A O   1 
ATOM   2965 C  CB  . ALA   A 1 412 ? 8.522   -36.196 -31.558 1.00 31.60  ? 675  ALA   A CB  1 
ATOM   2966 N  N   . SER   A 1 413 ? 9.197   -33.031 -31.189 1.00 32.05  ? 676  SER   A N   1 
ATOM   2967 C  CA  . SER   A 1 413 ? 10.043  -32.011 -30.514 1.00 33.26  ? 676  SER   A CA  1 
ATOM   2968 C  C   . SER   A 1 413 ? 9.523   -30.606 -30.791 1.00 35.45  ? 676  SER   A C   1 
ATOM   2969 O  O   . SER   A 1 413 ? 10.213  -29.668 -30.449 1.00 38.24  ? 676  SER   A O   1 
ATOM   2970 C  CB  . SER   A 1 413 ? 11.531  -32.139 -30.929 1.00 38.64  ? 676  SER   A CB  1 
ATOM   2971 O  OG  . SER   A 1 413 ? 11.631  -32.251 -32.349 1.00 42.79  ? 676  SER   A OG  1 
ATOM   2972 N  N   . ALA   A 1 414 ? 8.332   -30.456 -31.376 1.00 36.60  ? 677  ALA   A N   1 
ATOM   2973 C  CA  . ALA   A 1 414 ? 7.707   -29.135 -31.597 1.00 37.13  ? 677  ALA   A CA  1 
ATOM   2974 C  C   . ALA   A 1 414 ? 6.948   -28.764 -30.321 1.00 36.34  ? 677  ALA   A C   1 
ATOM   2975 O  O   . ALA   A 1 414 ? 5.732   -29.117 -30.236 1.00 37.32  ? 677  ALA   A O   1 
ATOM   2976 C  CB  . ALA   A 1 414 ? 6.815   -29.225 -32.804 1.00 36.56  ? 677  ALA   A CB  1 
ATOM   2977 N  N   . LEU   A 1 415 ? 7.620   -28.148 -29.344 1.00 32.51  ? 678  LEU   A N   1 
ATOM   2978 C  CA  . LEU   A 1 415 ? 7.117   -27.980 -27.948 1.00 33.85  ? 678  LEU   A CA  1 
ATOM   2979 C  C   . LEU   A 1 415 ? 6.956   -26.503 -27.570 1.00 33.59  ? 678  LEU   A C   1 
ATOM   2980 O  O   . LEU   A 1 415 ? 6.322   -26.241 -26.541 1.00 36.72  ? 678  LEU   A O   1 
ATOM   2981 C  CB  . LEU   A 1 415 ? 8.023   -28.704 -26.950 1.00 32.59  ? 678  LEU   A CB  1 
ATOM   2982 C  CG  . LEU   A 1 415 ? 8.241   -30.213 -27.216 1.00 36.69  ? 678  LEU   A CG  1 
ATOM   2983 C  CD1 . LEU   A 1 415 ? 9.342   -30.810 -26.338 1.00 37.47  ? 678  LEU   A CD1 1 
ATOM   2984 C  CD2 . LEU   A 1 415 ? 6.970   -31.001 -27.024 1.00 37.73  ? 678  LEU   A CD2 1 
ATOM   2985 N  N   . THR   A 1 416 ? 7.430   -25.540 -28.354 1.00 34.82  ? 679  THR   A N   1 
ATOM   2986 C  CA  . THR   A 1 416 ? 7.465   -24.130 -27.840 1.00 34.28  ? 679  THR   A CA  1 
ATOM   2987 C  C   . THR   A 1 416 ? 6.026   -23.594 -27.699 1.00 31.84  ? 679  THR   A C   1 
ATOM   2988 O  O   . THR   A 1 416 ? 5.665   -23.102 -26.601 1.00 33.65  ? 679  THR   A O   1 
ATOM   2989 C  CB  . THR   A 1 416 ? 8.377   -23.257 -28.702 1.00 35.58  ? 679  THR   A CB  1 
ATOM   2990 O  OG1 . THR   A 1 416 ? 7.909   -23.158 -30.047 1.00 37.83  ? 679  THR   A OG1 1 
ATOM   2991 C  CG2 . THR   A 1 416 ? 9.795   -23.786 -28.777 1.00 38.36  ? 679  THR   A CG2 1 
ATOM   2992 N  N   . ALA   A 1 417 ? 5.183   -23.725 -28.724 1.00 33.13  ? 680  ALA   A N   1 
ATOM   2993 C  CA  . ALA   A 1 417 ? 3.787   -23.210 -28.669 1.00 32.37  ? 680  ALA   A CA  1 
ATOM   2994 C  C   . ALA   A 1 417 ? 3.017   -23.984 -27.590 1.00 37.70  ? 680  ALA   A C   1 
ATOM   2995 O  O   . ALA   A 1 417 ? 2.338   -23.323 -26.782 1.00 36.10  ? 680  ALA   A O   1 
ATOM   2996 C  CB  . ALA   A 1 417 ? 3.146   -23.277 -30.017 1.00 35.52  ? 680  ALA   A CB  1 
ATOM   2997 N  N   . LEU   A 1 418 ? 3.183   -25.325 -27.520 1.00 34.88  ? 681  LEU   A N   1 
ATOM   2998 C  CA  . LEU   A 1 418 ? 2.401   -26.160 -26.589 1.00 32.88  ? 681  LEU   A CA  1 
ATOM   2999 C  C   . LEU   A 1 418 ? 2.713   -25.711 -25.169 1.00 32.24  ? 681  LEU   A C   1 
ATOM   3000 O  O   . LEU   A 1 418 ? 1.774   -25.593 -24.377 1.00 31.38  ? 681  LEU   A O   1 
ATOM   3001 C  CB  . LEU   A 1 418 ? 2.753   -27.642 -26.806 1.00 34.50  ? 681  LEU   A CB  1 
ATOM   3002 C  CG  . LEU   A 1 418 ? 1.887   -28.631 -26.032 1.00 36.24  ? 681  LEU   A CG  1 
ATOM   3003 C  CD1 . LEU   A 1 418 ? 0.480   -28.710 -26.625 1.00 37.68  ? 681  LEU   A CD1 1 
ATOM   3004 C  CD2 . LEU   A 1 418 ? 2.528   -30.005 -26.018 1.00 36.12  ? 681  LEU   A CD2 1 
ATOM   3005 N  N   . ASN   A 1 419 ? 4.010   -25.519 -24.845 1.00 36.38  ? 682  ASN   A N   1 
ATOM   3006 C  CA  . ASN   A 1 419 ? 4.428   -25.122 -23.472 1.00 36.09  ? 682  ASN   A CA  1 
ATOM   3007 C  C   . ASN   A 1 419 ? 3.976   -23.671 -23.261 1.00 33.97  ? 682  ASN   A C   1 
ATOM   3008 O  O   . ASN   A 1 419 ? 3.424   -23.364 -22.217 1.00 35.77  ? 682  ASN   A O   1 
ATOM   3009 C  CB  . ASN   A 1 419 ? 5.929   -25.334 -23.261 1.00 41.73  ? 682  ASN   A CB  1 
ATOM   3010 C  CG  . ASN   A 1 419 ? 6.305   -26.793 -23.039 1.00 43.16  ? 682  ASN   A CG  1 
ATOM   3011 O  OD1 . ASN   A 1 419 ? 5.543   -27.568 -22.463 1.00 41.65  ? 682  ASN   A OD1 1 
ATOM   3012 N  ND2 . ASN   A 1 419 ? 7.496   -27.178 -23.456 1.00 41.14  ? 682  ASN   A ND2 1 
ATOM   3013 N  N   . ASP   A 1 420 ? 4.140   -22.808 -24.242 1.00 33.39  ? 683  ASP   A N   1 
ATOM   3014 C  CA  . ASP   A 1 420 ? 3.766   -21.373 -24.042 1.00 38.60  ? 683  ASP   A CA  1 
ATOM   3015 C  C   . ASP   A 1 420 ? 2.233   -21.187 -23.897 1.00 41.53  ? 683  ASP   A C   1 
ATOM   3016 O  O   . ASP   A 1 420 ? 1.832   -20.254 -23.202 1.00 39.55  ? 683  ASP   A O   1 
ATOM   3017 C  CB  . ASP   A 1 420 ? 4.276   -20.478 -25.170 1.00 38.00  ? 683  ASP   A CB  1 
ATOM   3018 C  CG  . ASP   A 1 420 ? 4.208   -18.994 -24.778 1.00 41.53  ? 683  ASP   A CG  1 
ATOM   3019 O  OD1 . ASP   A 1 420 ? 4.571   -18.683 -23.620 1.00 41.93  ? 683  ASP   A OD1 1 
ATOM   3020 O  OD2 . ASP   A 1 420 ? 3.734   -18.185 -25.610 1.00 40.81  ? 683  ASP   A OD2 1 
ATOM   3021 N  N   . MET   A 1 421 ? 1.396   -22.056 -24.491 1.00 40.10  ? 684  MET   A N   1 
ATOM   3022 C  CA  . MET   A 1 421 ? -0.082  -21.995 -24.347 1.00 35.79  ? 684  MET   A CA  1 
ATOM   3023 C  C   . MET   A 1 421 ? -0.464  -22.464 -22.948 1.00 36.56  ? 684  MET   A C   1 
ATOM   3024 O  O   . MET   A 1 421 ? -1.635  -22.369 -22.605 1.00 38.48  ? 684  MET   A O   1 
ATOM   3025 C  CB  . MET   A 1 421 ? -0.815  -22.807 -25.423 1.00 35.73  ? 684  MET   A CB  1 
ATOM   3026 C  CG  . MET   A 1 421 ? -0.706  -22.194 -26.798 1.00 37.08  ? 684  MET   A CG  1 
ATOM   3027 S  SD  . MET   A 1 421 ? -1.560  -23.161 -28.136 1.00 44.13  ? 684  MET   A SD  1 
ATOM   3028 C  CE  . MET   A 1 421 ? -0.647  -24.698 -28.131 1.00 46.15  ? 684  MET   A CE  1 
ATOM   3029 N  N   . GLY   A 1 422 ? 0.488   -22.997 -22.179 1.00 39.29  ? 685  GLY   A N   1 
ATOM   3030 C  CA  . GLY   A 1 422 ? 0.256   -23.585 -20.839 1.00 31.01  ? 685  GLY   A CA  1 
ATOM   3031 C  C   . GLY   A 1 422 ? -0.136  -25.059 -20.856 1.00 33.98  ? 685  GLY   A C   1 
ATOM   3032 O  O   . GLY   A 1 422 ? -0.345  -25.612 -19.786 1.00 34.59  ? 685  GLY   A O   1 
ATOM   3033 N  N   . LYS   A 1 423 ? -0.240  -25.701 -22.008 1.00 30.42  ? 686  LYS   A N   1 
ATOM   3034 C  CA  . LYS   A 1 423 ? -0.641  -27.147 -22.088 1.00 35.07  ? 686  LYS   A CA  1 
ATOM   3035 C  C   . LYS   A 1 423 ? 0.580   -28.075 -21.907 1.00 34.86  ? 686  LYS   A C   1 
ATOM   3036 O  O   . LYS   A 1 423 ? 0.894   -28.875 -22.817 1.00 35.25  ? 686  LYS   A O   1 
ATOM   3037 C  CB  . LYS   A 1 423 ? -1.408  -27.372 -23.382 1.00 31.58  ? 686  LYS   A CB  1 
ATOM   3038 C  CG  . LYS   A 1 423 ? -2.515  -26.347 -23.571 1.00 32.15  ? 686  LYS   A CG  1 
ATOM   3039 C  CD  . LYS   A 1 423 ? -3.488  -26.287 -22.400 1.00 34.94  ? 686  LYS   A CD  1 
ATOM   3040 C  CE  . LYS   A 1 423 ? -4.667  -25.384 -22.666 1.00 40.24  ? 686  LYS   A CE  1 
ATOM   3041 N  NZ  . LYS   A 1 423 ? -4.310  -23.970 -22.343 1.00 44.53  ? 686  LYS   A NZ  1 
ATOM   3042 N  N   . VAL   A 1 424 ? 1.148   -28.032 -20.700 1.00 37.15  ? 687  VAL   A N   1 
ATOM   3043 C  CA  . VAL   A 1 424 ? 2.379   -28.772 -20.285 1.00 36.36  ? 687  VAL   A CA  1 
ATOM   3044 C  C   . VAL   A 1 424 ? 2.038   -30.255 -20.165 1.00 31.02  ? 687  VAL   A C   1 
ATOM   3045 O  O   . VAL   A 1 424 ? 1.038   -30.606 -19.468 1.00 36.51  ? 687  VAL   A O   1 
ATOM   3046 C  CB  . VAL   A 1 424 ? 2.965   -28.161 -18.980 1.00 43.35  ? 687  VAL   A CB  1 
ATOM   3047 C  CG1 . VAL   A 1 424 ? 4.034   -29.016 -18.327 1.00 49.54  ? 687  VAL   A CG1 1 
ATOM   3048 C  CG2 . VAL   A 1 424 ? 3.532   -26.767 -19.226 1.00 49.14  ? 687  VAL   A CG2 1 
ATOM   3049 N  N   . ARG   A 1 425 ? 2.871   -31.106 -20.768 1.00 30.35  ? 688  ARG   A N   1 
ATOM   3050 C  CA  . ARG   A 1 425 ? 2.660   -32.575 -20.806 1.00 36.00  ? 688  ARG   A CA  1 
ATOM   3051 C  C   . ARG   A 1 425 ? 2.885   -33.163 -19.415 1.00 36.01  ? 688  ARG   A C   1 
ATOM   3052 O  O   . ARG   A 1 425 ? 3.738   -32.636 -18.708 1.00 41.23  ? 688  ARG   A O   1 
ATOM   3053 C  CB  . ARG   A 1 425 ? 3.561   -33.235 -21.847 1.00 32.93  ? 688  ARG   A CB  1 
ATOM   3054 C  CG  . ARG   A 1 425 ? 3.194   -32.848 -23.268 1.00 34.00  ? 688  ARG   A CG  1 
ATOM   3055 C  CD  . ARG   A 1 425 ? 4.303   -33.128 -24.261 1.00 35.75  ? 688  ARG   A CD  1 
ATOM   3056 N  NE  . ARG   A 1 425 ? 5.539   -32.506 -23.804 1.00 36.45  ? 688  ARG   A NE  1 
ATOM   3057 C  CZ  . ARG   A 1 425 ? 6.783   -32.947 -24.054 1.00 36.74  ? 688  ARG   A CZ  1 
ATOM   3058 N  NH1 . ARG   A 1 425 ? 7.008   -33.984 -24.849 1.00 31.71  ? 688  ARG   A NH1 1 
ATOM   3059 N  NH2 . ARG   A 1 425 ? 7.810   -32.298 -23.521 1.00 40.07  ? 688  ARG   A NH2 1 
ATOM   3060 N  N   . LYS   A 1 426 ? 2.116   -34.203 -19.080 1.00 37.19  ? 689  LYS   A N   1 
ATOM   3061 C  CA  . LYS   A 1 426 ? 2.190   -34.998 -17.832 1.00 42.02  ? 689  LYS   A CA  1 
ATOM   3062 C  C   . LYS   A 1 426 ? 3.406   -35.961 -17.903 1.00 42.59  ? 689  LYS   A C   1 
ATOM   3063 O  O   . LYS   A 1 426 ? 3.647   -36.558 -18.962 1.00 43.19  ? 689  LYS   A O   1 
ATOM   3064 C  CB  . LYS   A 1 426 ? 0.863   -35.752 -17.677 1.00 45.44  ? 689  LYS   A CB  1 
ATOM   3065 C  CG  . LYS   A 1 426 ? 0.540   -36.284 -16.290 1.00 51.91  ? 689  LYS   A CG  1 
ATOM   3066 C  CD  . LYS   A 1 426 ? -0.768  -37.030 -16.239 1.00 61.17  ? 689  LYS   A CD  1 
ATOM   3067 C  CE  . LYS   A 1 426 ? -0.649  -38.407 -16.863 1.00 78.50  ? 689  LYS   A CE  1 
ATOM   3068 N  NZ  . LYS   A 1 426 ? -1.967  -39.040 -17.109 1.00 84.98  ? 689  LYS   A NZ  1 
ATOM   3069 N  N   . ASP   A 1 427 ? 4.177   -36.117 -16.827 1.00 49.73  ? 690  ASP   A N   1 
ATOM   3070 C  CA  . ASP   A 1 427 ? 5.115   -37.278 -16.661 1.00 51.21  ? 690  ASP   A CA  1 
ATOM   3071 C  C   . ASP   A 1 427 ? 6.189   -37.320 -17.768 1.00 49.70  ? 690  ASP   A C   1 
ATOM   3072 O  O   . ASP   A 1 427 ? 6.474   -38.431 -18.327 1.00 53.09  ? 690  ASP   A O   1 
ATOM   3073 C  CB  . ASP   A 1 427 ? 4.346   -38.597 -16.643 1.00 55.11  ? 690  ASP   A CB  1 
ATOM   3074 C  CG  . ASP   A 1 427 ? 3.413   -38.720 -15.452 1.00 64.22  ? 690  ASP   A CG  1 
ATOM   3075 O  OD1 . ASP   A 1 427 ? 3.677   -38.012 -14.436 1.00 63.15  ? 690  ASP   A OD1 1 
ATOM   3076 O  OD2 . ASP   A 1 427 ? 2.419   -39.514 -15.561 1.00 69.78  ? 690  ASP   A OD2 1 
ATOM   3077 N  N   . ILE   A 1 428 ? 6.759   -36.152 -18.078 0.50 45.00  ? 691  ILE   A N   1 
ATOM   3078 C  CA  . ILE   A 1 428 ? 7.908   -35.964 -19.012 0.50 45.79  ? 691  ILE   A CA  1 
ATOM   3079 C  C   . ILE   A 1 428 ? 8.455   -34.554 -18.783 0.50 46.31  ? 691  ILE   A C   1 
ATOM   3080 O  O   . ILE   A 1 428 ? 7.660   -33.671 -18.419 0.50 48.15  ? 691  ILE   A O   1 
ATOM   3081 C  CB  . ILE   A 1 428 ? 7.493   -36.193 -20.482 0.50 44.24  ? 691  ILE   A CB  1 
ATOM   3082 C  CG1 . ILE   A 1 428 ? 8.715   -36.351 -21.385 0.50 42.79  ? 691  ILE   A CG1 1 
ATOM   3083 C  CG2 . ILE   A 1 428 ? 6.570   -35.088 -20.973 0.50 42.90  ? 691  ILE   A CG2 1 
ATOM   3084 C  CD1 . ILE   A 1 428 ? 8.404   -36.898 -22.748 0.50 42.11  ? 691  ILE   A CD1 1 
ATOM   3085 N  N   . GLN   A 1 429 ? 9.761   -34.354 -18.966 1.00 48.24  ? 692  GLN   A N   1 
ATOM   3086 C  CA  . GLN   A 1 429 ? 10.397  -33.034 -18.714 1.00 48.30  ? 692  GLN   A CA  1 
ATOM   3087 C  C   . GLN   A 1 429 ? 9.990   -32.123 -19.857 1.00 42.68  ? 692  GLN   A C   1 
ATOM   3088 O  O   . GLN   A 1 429 ? 9.878   -32.584 -21.020 1.00 37.66  ? 692  GLN   A O   1 
ATOM   3089 C  CB  . GLN   A 1 429 ? 11.928  -33.062 -18.611 1.00 59.33  ? 692  GLN   A CB  1 
ATOM   3090 C  CG  . GLN   A 1 429 ? 12.478  -33.921 -17.473 1.00 79.94  ? 692  GLN   A CG  1 
ATOM   3091 C  CD  . GLN   A 1 429 ? 12.804  -35.345 -17.875 1.00 95.39  ? 692  GLN   A CD  1 
ATOM   3092 O  OE1 . GLN   A 1 429 ? 13.317  -35.615 -18.964 1.00 111.93 ? 692  GLN   A OE1 1 
ATOM   3093 N  NE2 . GLN   A 1 429 ? 12.512  -36.281 -16.985 1.00 103.11 ? 692  GLN   A NE2 1 
ATOM   3094 N  N   . GLN   A 1 430 ? 9.853   -30.863 -19.525 1.00 48.18  ? 693  GLN   A N   1 
ATOM   3095 C  CA  . GLN   A 1 430 ? 9.228   -29.832 -20.367 1.00 52.07  ? 693  GLN   A CA  1 
ATOM   3096 C  C   . GLN   A 1 430 ? 9.774   -29.892 -21.786 1.00 54.46  ? 693  GLN   A C   1 
ATOM   3097 O  O   . GLN   A 1 430 ? 8.987   -29.582 -22.734 1.00 45.22  ? 693  GLN   A O   1 
ATOM   3098 C  CB  . GLN   A 1 430 ? 9.484   -28.456 -19.764 1.00 61.36  ? 693  GLN   A CB  1 
ATOM   3099 C  CG  . GLN   A 1 430 ? 8.607   -27.405 -20.412 1.00 74.07  ? 693  GLN   A CG  1 
ATOM   3100 C  CD  . GLN   A 1 430 ? 8.541   -26.135 -19.610 1.00 73.71  ? 693  GLN   A CD  1 
ATOM   3101 O  OE1 . GLN   A 1 430 ? 7.470   -25.544 -19.467 1.00 69.86  ? 693  GLN   A OE1 1 
ATOM   3102 N  NE2 . GLN   A 1 430 ? 9.685   -25.730 -19.076 1.00 67.36  ? 693  GLN   A NE2 1 
ATOM   3103 N  N   . TRP   A 1 431 ? 11.071  -30.181 -21.953 1.00 43.17  ? 694  TRP   A N   1 
ATOM   3104 C  CA  . TRP   A 1 431 ? 11.704  -30.014 -23.280 1.00 42.28  ? 694  TRP   A CA  1 
ATOM   3105 C  C   . TRP   A 1 431 ? 12.123  -31.344 -23.908 1.00 41.68  ? 694  TRP   A C   1 
ATOM   3106 O  O   . TRP   A 1 431 ? 12.668  -31.317 -25.006 1.00 42.49  ? 694  TRP   A O   1 
ATOM   3107 C  CB  . TRP   A 1 431 ? 12.829  -28.983 -23.189 1.00 48.72  ? 694  TRP   A CB  1 
ATOM   3108 C  CG  . TRP   A 1 431 ? 12.332  -27.622 -22.776 1.00 60.13  ? 694  TRP   A CG  1 
ATOM   3109 C  CD1 . TRP   A 1 431 ? 12.553  -27.002 -21.579 1.00 60.82  ? 694  TRP   A CD1 1 
ATOM   3110 C  CD2 . TRP   A 1 431 ? 11.481  -26.730 -23.534 1.00 53.09  ? 694  TRP   A CD2 1 
ATOM   3111 N  NE1 . TRP   A 1 431 ? 11.925  -25.783 -21.550 1.00 61.45  ? 694  TRP   A NE1 1 
ATOM   3112 C  CE2 . TRP   A 1 431 ? 11.259  -25.587 -22.731 1.00 60.87  ? 694  TRP   A CE2 1 
ATOM   3113 C  CE3 . TRP   A 1 431 ? 10.903  -26.770 -24.809 1.00 52.03  ? 694  TRP   A CE3 1 
ATOM   3114 C  CZ2 . TRP   A 1 431 ? 10.450  -24.524 -23.143 1.00 57.73  ? 694  TRP   A CZ2 1 
ATOM   3115 C  CZ3 . TRP   A 1 431 ? 10.139  -25.700 -25.235 1.00 56.70  ? 694  TRP   A CZ3 1 
ATOM   3116 C  CH2 . TRP   A 1 431 ? 9.907   -24.599 -24.408 1.00 57.13  ? 694  TRP   A CH2 1 
ATOM   3117 N  N   . GLU   A 1 432 ? 11.834  -32.464 -23.241 0.50 41.19  ? 695  GLU   A N   1 
ATOM   3118 C  CA  . GLU   A 1 432 ? 12.155  -33.830 -23.734 0.50 43.37  ? 695  GLU   A CA  1 
ATOM   3119 C  C   . GLU   A 1 432 ? 11.124  -34.186 -24.807 0.50 41.98  ? 695  GLU   A C   1 
ATOM   3120 O  O   . GLU   A 1 432 ? 9.923   -34.020 -24.592 0.50 40.80  ? 695  GLU   A O   1 
ATOM   3121 C  CB  . GLU   A 1 432 ? 12.193  -34.802 -22.551 0.50 46.60  ? 695  GLU   A CB  1 
ATOM   3122 C  CG  . GLU   A 1 432 ? 13.417  -35.712 -22.530 0.50 51.36  ? 695  GLU   A CG  1 
ATOM   3123 C  CD  . GLU   A 1 432 ? 14.772  -35.053 -22.793 0.50 55.42  ? 695  GLU   A CD  1 
ATOM   3124 O  OE1 . GLU   A 1 432 ? 15.373  -35.332 -23.863 0.50 57.55  ? 695  GLU   A OE1 1 
ATOM   3125 O  OE2 . GLU   A 1 432 ? 15.248  -34.284 -21.924 0.50 52.78  ? 695  GLU   A OE2 1 
ATOM   3126 N  N   . PRO   A 1 433 ? 11.548  -34.654 -26.002 1.00 39.83  ? 696  PRO   A N   1 
ATOM   3127 C  CA  . PRO   A 1 433 ? 10.610  -34.924 -27.087 1.00 36.80  ? 696  PRO   A CA  1 
ATOM   3128 C  C   . PRO   A 1 433 ? 9.601   -36.005 -26.681 1.00 34.39  ? 696  PRO   A C   1 
ATOM   3129 O  O   . PRO   A 1 433 ? 9.909   -36.866 -25.934 1.00 32.17  ? 696  PRO   A O   1 
ATOM   3130 C  CB  . PRO   A 1 433 ? 11.480  -35.429 -28.246 1.00 43.18  ? 696  PRO   A CB  1 
ATOM   3131 C  CG  . PRO   A 1 433 ? 12.914  -34.987 -27.848 1.00 48.56  ? 696  PRO   A CG  1 
ATOM   3132 C  CD  . PRO   A 1 433 ? 12.951  -35.009 -26.335 1.00 40.68  ? 696  PRO   A CD  1 
ATOM   3133 N  N   . SER   A 1 434 ? 8.374   -35.894 -27.193 0.50 33.21  ? 697  SER   A N   1 
ATOM   3134 C  CA  . SER   A 1 434 ? 7.282   -36.872 -26.970 0.50 32.99  ? 697  SER   A CA  1 
ATOM   3135 C  C   . SER   A 1 434 ? 7.708   -38.244 -27.492 0.50 33.71  ? 697  SER   A C   1 
ATOM   3136 O  O   . SER   A 1 434 ? 8.351   -38.290 -28.545 0.50 38.48  ? 697  SER   A O   1 
ATOM   3137 C  CB  . SER   A 1 434 ? 6.012   -36.412 -27.639 0.50 31.58  ? 697  SER   A CB  1 
ATOM   3138 O  OG  . SER   A 1 434 ? 5.510   -35.242 -27.019 0.50 29.45  ? 697  SER   A OG  1 
ATOM   3139 N  N   . ARG   A 1 435 ? 7.326   -39.320 -26.804 0.50 37.08  ? 698  ARG   A N   1 
ATOM   3140 C  CA  . ARG   A 1 435 ? 7.454   -40.712 -27.318 0.50 42.26  ? 698  ARG   A CA  1 
ATOM   3141 C  C   . ARG   A 1 435 ? 6.147   -41.111 -28.025 0.50 38.45  ? 698  ARG   A C   1 
ATOM   3142 O  O   . ARG   A 1 435 ? 5.080   -41.054 -27.391 0.50 37.54  ? 698  ARG   A O   1 
ATOM   3143 C  CB  . ARG   A 1 435 ? 7.805   -41.653 -26.161 0.50 51.04  ? 698  ARG   A CB  1 
ATOM   3144 C  CG  . ARG   A 1 435 ? 9.224   -41.456 -25.641 0.50 60.62  ? 698  ARG   A CG  1 
ATOM   3145 C  CD  . ARG   A 1 435 ? 9.492   -42.116 -24.299 0.50 68.16  ? 698  ARG   A CD  1 
ATOM   3146 N  NE  . ARG   A 1 435 ? 9.518   -41.167 -23.188 0.50 78.23  ? 698  ARG   A NE  1 
ATOM   3147 C  CZ  . ARG   A 1 435 ? 10.495  -40.287 -22.968 0.50 82.41  ? 698  ARG   A CZ  1 
ATOM   3148 N  NH1 . ARG   A 1 435 ? 11.524  -40.218 -23.796 0.50 85.60  ? 698  ARG   A NH1 1 
ATOM   3149 N  NH2 . ARG   A 1 435 ? 10.438  -39.471 -21.929 0.50 82.81  ? 698  ARG   A NH2 1 
ATOM   3150 N  N   . GLY   A 1 436 ? 6.231   -41.510 -29.292 1.00 36.39  ? 699  GLY   A N   1 
ATOM   3151 C  CA  . GLY   A 1 436 ? 5.062   -41.885 -30.088 1.00 37.77  ? 699  GLY   A CA  1 
ATOM   3152 C  C   . GLY   A 1 436 ? 4.802   -43.380 -29.996 1.00 38.30  ? 699  GLY   A C   1 
ATOM   3153 O  O   . GLY   A 1 436 ? 5.652   -44.075 -29.483 1.00 35.22  ? 699  GLY   A O   1 
ATOM   3154 N  N   . TRP   A 1 437 ? 3.659   -43.828 -30.500 1.00 33.28  ? 700  TRP   A N   1 
ATOM   3155 C  CA  . TRP   A 1 437 ? 3.285   -45.248 -30.589 1.00 31.97  ? 700  TRP   A CA  1 
ATOM   3156 C  C   . TRP   A 1 437 ? 3.397   -45.655 -32.049 1.00 32.94  ? 700  TRP   A C   1 
ATOM   3157 O  O   . TRP   A 1 437 ? 2.939   -44.907 -32.912 1.00 32.76  ? 700  TRP   A O   1 
ATOM   3158 C  CB  . TRP   A 1 437 ? 1.887   -45.437 -30.001 1.00 32.34  ? 700  TRP   A CB  1 
ATOM   3159 C  CG  . TRP   A 1 437 ? 1.767   -44.962 -28.594 1.00 28.69  ? 700  TRP   A CG  1 
ATOM   3160 C  CD1 . TRP   A 1 437 ? 1.475   -43.696 -28.170 1.00 32.05  ? 700  TRP   A CD1 1 
ATOM   3161 C  CD2 . TRP   A 1 437 ? 1.929   -45.751 -27.406 1.00 28.24  ? 700  TRP   A CD2 1 
ATOM   3162 N  NE1 . TRP   A 1 437 ? 1.437   -43.653 -26.800 1.00 33.07  ? 700  TRP   A NE1 1 
ATOM   3163 C  CE2 . TRP   A 1 437 ? 1.713   -44.897 -26.309 1.00 31.62  ? 700  TRP   A CE2 1 
ATOM   3164 C  CE3 . TRP   A 1 437 ? 2.214   -47.088 -27.193 1.00 32.28  ? 700  TRP   A CE3 1 
ATOM   3165 C  CZ2 . TRP   A 1 437 ? 1.743   -45.342 -24.993 1.00 33.11  ? 700  TRP   A CZ2 1 
ATOM   3166 C  CZ3 . TRP   A 1 437 ? 2.286   -47.524 -25.899 1.00 32.65  ? 700  TRP   A CZ3 1 
ATOM   3167 C  CH2 . TRP   A 1 437 ? 2.017   -46.674 -24.829 1.00 33.33  ? 700  TRP   A CH2 1 
ATOM   3168 N  N   . ASN   A 1 438 ? 4.037   -46.782 -32.314 1.00 30.87  ? 701  ASN   A N   1 
ATOM   3169 C  CA  . ASN   A 1 438 ? 4.156   -47.306 -33.684 1.00 34.31  ? 701  ASN   A CA  1 
ATOM   3170 C  C   . ASN   A 1 438 ? 2.982   -48.201 -34.029 1.00 35.95  ? 701  ASN   A C   1 
ATOM   3171 O  O   . ASN   A 1 438 ? 2.925   -48.581 -35.168 1.00 40.72  ? 701  ASN   A O   1 
ATOM   3172 C  CB  . ASN   A 1 438 ? 5.436   -48.143 -33.844 1.00 44.77  ? 701  ASN   A CB  1 
ATOM   3173 C  CG  . ASN   A 1 438 ? 6.659   -47.333 -33.458 1.00 54.86  ? 701  ASN   A CG  1 
ATOM   3174 O  OD1 . ASN   A 1 438 ? 7.494   -47.779 -32.660 1.00 63.50  ? 701  ASN   A OD1 1 
ATOM   3175 N  ND2 . ASN   A 1 438 ? 6.712   -46.109 -33.961 1.00 45.15  ? 701  ASN   A ND2 1 
ATOM   3176 N  N   . ASP   A 1 439 ? 2.091   -48.557 -33.108 1.00 36.15  ? 702  ASP   A N   1 
ATOM   3177 C  CA  . ASP   A 1 439 ? 0.976   -49.491 -33.477 1.00 38.92  ? 702  ASP   A CA  1 
ATOM   3178 C  C   . ASP   A 1 439 ? -0.295  -48.960 -32.828 1.00 32.53  ? 702  ASP   A C   1 
ATOM   3179 O  O   . ASP   A 1 439 ? -0.300  -48.781 -31.576 1.00 28.55  ? 702  ASP   A O   1 
ATOM   3180 C  CB  . ASP   A 1 439 ? 1.449   -50.918 -33.149 1.00 41.02  ? 702  ASP   A CB  1 
ATOM   3181 C  CG  . ASP   A 1 439 ? 0.421   -52.027 -32.996 1.00 50.37  ? 702  ASP   A CG  1 
ATOM   3182 O  OD1 . ASP   A 1 439 ? -0.738  -51.875 -33.508 1.00 45.47  ? 702  ASP   A OD1 1 
ATOM   3183 O  OD2 . ASP   A 1 439 ? 0.817   -53.079 -32.353 1.00 56.72  ? 702  ASP   A OD2 1 
ATOM   3184 N  N   . TRP   A 1 440 ? -1.318  -48.698 -33.640 1.00 30.11  ? 703  TRP   A N   1 
ATOM   3185 C  CA  . TRP   A 1 440 ? -2.611  -48.148 -33.171 1.00 29.50  ? 703  TRP   A CA  1 
ATOM   3186 C  C   . TRP   A 1 440 ? -3.221  -49.018 -32.058 1.00 29.01  ? 703  TRP   A C   1 
ATOM   3187 O  O   . TRP   A 1 440 ? -3.998  -48.487 -31.212 1.00 26.36  ? 703  TRP   A O   1 
ATOM   3188 C  CB  . TRP   A 1 440 ? -3.551  -47.950 -34.352 1.00 28.85  ? 703  TRP   A CB  1 
ATOM   3189 C  CG  . TRP   A 1 440 ? -4.082  -49.204 -34.981 1.00 30.33  ? 703  TRP   A CG  1 
ATOM   3190 C  CD1 . TRP   A 1 440 ? -3.543  -49.846 -36.062 1.00 35.99  ? 703  TRP   A CD1 1 
ATOM   3191 C  CD2 . TRP   A 1 440 ? -5.225  -49.982 -34.605 1.00 31.39  ? 703  TRP   A CD2 1 
ATOM   3192 N  NE1 . TRP   A 1 440 ? -4.295  -50.929 -36.413 1.00 29.77  ? 703  TRP   A NE1 1 
ATOM   3193 C  CE2 . TRP   A 1 440 ? -5.315  -51.067 -35.523 1.00 31.12  ? 703  TRP   A CE2 1 
ATOM   3194 C  CE3 . TRP   A 1 440 ? -6.210  -49.857 -33.627 1.00 29.26  ? 703  TRP   A CE3 1 
ATOM   3195 C  CZ2 . TRP   A 1 440 ? -6.313  -52.042 -35.460 1.00 28.49  ? 703  TRP   A CZ2 1 
ATOM   3196 C  CZ3 . TRP   A 1 440 ? -7.205  -50.813 -33.573 1.00 29.55  ? 703  TRP   A CZ3 1 
ATOM   3197 C  CH2 . TRP   A 1 440 ? -7.259  -51.883 -34.475 1.00 31.41  ? 703  TRP   A CH2 1 
ATOM   3198 N  N   . THR   A 1 441 ? -2.892  -50.304 -32.015 1.00 27.19  ? 704  THR   A N   1 
ATOM   3199 C  CA  . THR   A 1 441 ? -3.434  -51.239 -30.994 1.00 27.30  ? 704  THR   A CA  1 
ATOM   3200 C  C   . THR   A 1 441 ? -2.807  -51.027 -29.615 1.00 27.29  ? 704  THR   A C   1 
ATOM   3201 O  O   . THR   A 1 441 ? -3.280  -51.628 -28.655 1.00 29.02  ? 704  THR   A O   1 
ATOM   3202 C  CB  . THR   A 1 441 ? -3.378  -52.721 -31.412 1.00 28.65  ? 704  THR   A CB  1 
ATOM   3203 O  OG1 . THR   A 1 441 ? -2.031  -53.187 -31.489 1.00 29.34  ? 704  THR   A OG1 1 
ATOM   3204 C  CG2 . THR   A 1 441 ? -4.060  -52.969 -32.745 1.00 26.33  ? 704  THR   A CG2 1 
ATOM   3205 N  N   . GLN   A 1 442 ? -1.759  -50.203 -29.518 0.50 27.59  ? 705  GLN   A N   1 
ATOM   3206 C  CA  . GLN   A 1 442 ? -1.055  -49.902 -28.243 0.50 28.32  ? 705  GLN   A CA  1 
ATOM   3207 C  C   . GLN   A 1 442 ? -1.373  -48.477 -27.772 0.50 25.29  ? 705  GLN   A C   1 
ATOM   3208 O  O   . GLN   A 1 442 ? -0.941  -48.132 -26.671 0.50 25.87  ? 705  GLN   A O   1 
ATOM   3209 C  CB  . GLN   A 1 442 ? 0.455   -50.092 -28.416 0.50 31.08  ? 705  GLN   A CB  1 
ATOM   3210 C  CG  . GLN   A 1 442 ? 0.821   -51.385 -29.138 0.50 32.60  ? 705  GLN   A CG  1 
ATOM   3211 C  CD  . GLN   A 1 442 ? 0.364   -52.611 -28.393 0.50 33.76  ? 705  GLN   A CD  1 
ATOM   3212 O  OE1 . GLN   A 1 442 ? 0.736   -52.826 -27.243 0.50 31.85  ? 705  GLN   A OE1 1 
ATOM   3213 N  NE2 . GLN   A 1 442 ? -0.430  -53.446 -29.055 0.50 37.18  ? 705  GLN   A NE2 1 
ATOM   3214 N  N   . VAL   A 1 443 ? -2.068  -47.676 -28.574 1.00 23.67  ? 706  VAL   A N   1 
ATOM   3215 C  CA  . VAL   A 1 443 ? -2.334  -46.229 -28.241 1.00 27.34  ? 706  VAL   A CA  1 
ATOM   3216 C  C   . VAL   A 1 443 ? -3.358  -46.146 -27.126 1.00 21.98  ? 706  VAL   A C   1 
ATOM   3217 O  O   . VAL   A 1 443 ? -4.402  -46.767 -27.220 1.00 25.80  ? 706  VAL   A O   1 
ATOM   3218 C  CB  . VAL   A 1 443 ? -2.812  -45.456 -29.485 1.00 30.64  ? 706  VAL   A CB  1 
ATOM   3219 C  CG1 . VAL   A 1 443 ? -3.252  -44.029 -29.191 1.00 34.83  ? 706  VAL   A CG1 1 
ATOM   3220 C  CG2 . VAL   A 1 443 ? -1.677  -45.417 -30.480 1.00 34.86  ? 706  VAL   A CG2 1 
ATOM   3221 N  N   . PRO   A 1 444 ? -3.126  -45.401 -26.037 1.00 22.76  ? 707  PRO   A N   1 
ATOM   3222 C  CA  . PRO   A 1 444 ? -4.194  -45.166 -25.071 1.00 23.04  ? 707  PRO   A CA  1 
ATOM   3223 C  C   . PRO   A 1 444 ? -5.176  -44.089 -25.562 1.00 25.53  ? 707  PRO   A C   1 
ATOM   3224 O  O   . PRO   A 1 444 ? -4.720  -43.063 -26.061 1.00 24.03  ? 707  PRO   A O   1 
ATOM   3225 C  CB  . PRO   A 1 444 ? -3.412  -44.730 -23.854 1.00 24.94  ? 707  PRO   A CB  1 
ATOM   3226 C  CG  . PRO   A 1 444 ? -2.210  -43.964 -24.442 1.00 23.77  ? 707  PRO   A CG  1 
ATOM   3227 C  CD  . PRO   A 1 444 ? -1.884  -44.653 -25.736 1.00 23.43  ? 707  PRO   A CD  1 
ATOM   3228 N  N   . PHE   A 1 445 ? -6.478  -44.273 -25.351 1.00 23.10  ? 708  PHE   A N   1 
ATOM   3229 C  CA  . PHE   A 1 445 ? -7.491  -43.210 -25.644 1.00 23.08  ? 708  PHE   A CA  1 
ATOM   3230 C  C   . PHE   A 1 445 ? -8.730  -43.464 -24.810 1.00 23.80  ? 708  PHE   A C   1 
ATOM   3231 O  O   . PHE   A 1 445 ? -9.213  -44.622 -24.862 1.00 19.60  ? 708  PHE   A O   1 
ATOM   3232 C  CB  . PHE   A 1 445 ? -7.860  -43.248 -27.135 1.00 21.66  ? 708  PHE   A CB  1 
ATOM   3233 C  CG  . PHE   A 1 445 ? -8.706  -42.089 -27.641 1.00 25.89  ? 708  PHE   A CG  1 
ATOM   3234 C  CD1 . PHE   A 1 445 ? -8.395  -40.781 -27.325 1.00 25.00  ? 708  PHE   A CD1 1 
ATOM   3235 C  CD2 . PHE   A 1 445 ? -9.818  -42.317 -28.428 1.00 25.53  ? 708  PHE   A CD2 1 
ATOM   3236 C  CE1 . PHE   A 1 445 ? -9.159  -39.721 -27.793 1.00 27.26  ? 708  PHE   A CE1 1 
ATOM   3237 C  CE2 . PHE   A 1 445 ? -10.562 -41.265 -28.939 1.00 27.90  ? 708  PHE   A CE2 1 
ATOM   3238 C  CZ  . PHE   A 1 445 ? -10.252 -39.965 -28.584 1.00 27.34  ? 708  PHE   A CZ  1 
ATOM   3239 N  N   . CYS   A 1 446 ? -9.232  -42.458 -24.098 1.00 24.31  ? 709  CYS   A N   1 
ATOM   3240 C  CA  . CYS   A 1 446 ? -10.487 -42.548 -23.276 1.00 27.84  ? 709  CYS   A CA  1 
ATOM   3241 C  C   . CYS   A 1 446 ? -10.418 -43.769 -22.334 1.00 25.51  ? 709  CYS   A C   1 
ATOM   3242 O  O   . CYS   A 1 446 ? -11.391 -44.531 -22.295 1.00 27.77  ? 709  CYS   A O   1 
ATOM   3243 C  CB  . CYS   A 1 446 ? -11.700 -42.643 -24.190 1.00 31.42  ? 709  CYS   A CB  1 
ATOM   3244 S  SG  . CYS   A 1 446 ? -11.914 -41.142 -25.184 1.00 32.00  ? 709  CYS   A SG  1 
ATOM   3245 N  N   . SER   A 1 447 ? -9.263  -43.949 -21.688 1.00 24.88  ? 710  SER   A N   1 
ATOM   3246 C  CA  . SER   A 1 447 ? -8.941  -44.955 -20.651 1.00 31.07  ? 710  SER   A CA  1 
ATOM   3247 C  C   . SER   A 1 447 ? -8.911  -46.374 -21.245 1.00 30.05  ? 710  SER   A C   1 
ATOM   3248 O  O   . SER   A 1 447 ? -8.798  -47.324 -20.466 1.00 30.42  ? 710  SER   A O   1 
ATOM   3249 C  CB  . SER   A 1 447 ? -9.948  -44.908 -19.486 1.00 34.30  ? 710  SER   A CB  1 
ATOM   3250 O  OG  . SER   A 1 447 ? -10.226 -43.594 -19.076 1.00 37.86  ? 710  SER   A OG  1 
ATOM   3251 N  N   . HIS   A 1 448 ? -8.865  -46.531 -22.563 1.00 25.02  ? 711  HIS   A N   1 
ATOM   3252 C  CA  . HIS   A 1 448 ? -8.872  -47.867 -23.213 1.00 23.11  ? 711  HIS   A CA  1 
ATOM   3253 C  C   . HIS   A 1 448 ? -7.664  -48.035 -24.145 1.00 21.74  ? 711  HIS   A C   1 
ATOM   3254 O  O   . HIS   A 1 448 ? -6.950  -47.036 -24.463 1.00 20.10  ? 711  HIS   A O   1 
ATOM   3255 C  CB  . HIS   A 1 448 ? -10.177 -48.082 -24.018 1.00 21.44  ? 711  HIS   A CB  1 
ATOM   3256 C  CG  . HIS   A 1 448 ? -11.369 -48.274 -23.153 1.00 22.26  ? 711  HIS   A CG  1 
ATOM   3257 N  ND1 . HIS   A 1 448 ? -11.938 -47.224 -22.416 1.00 24.08  ? 711  HIS   A ND1 1 
ATOM   3258 C  CD2 . HIS   A 1 448 ? -12.070 -49.398 -22.872 1.00 22.72  ? 711  HIS   A CD2 1 
ATOM   3259 C  CE1 . HIS   A 1 448 ? -12.938 -47.734 -21.674 1.00 27.11  ? 711  HIS   A CE1 1 
ATOM   3260 N  NE2 . HIS   A 1 448 ? -13.063 -49.084 -21.965 1.00 22.74  ? 711  HIS   A NE2 1 
ATOM   3261 N  N   . HIS   A 1 449 ? -7.433  -49.278 -24.542 1.00 20.05  ? 712  HIS   A N   1 
ATOM   3262 C  CA  . HIS   A 1 449 ? -6.713  -49.614 -25.796 1.00 20.86  ? 712  HIS   A CA  1 
ATOM   3263 C  C   . HIS   A 1 449 ? -7.649  -50.506 -26.597 1.00 21.24  ? 712  HIS   A C   1 
ATOM   3264 O  O   . HIS   A 1 449 ? -8.710  -50.866 -26.083 1.00 21.07  ? 712  HIS   A O   1 
ATOM   3265 C  CB  . HIS   A 1 449 ? -5.398  -50.362 -25.536 1.00 21.39  ? 712  HIS   A CB  1 
ATOM   3266 C  CG  . HIS   A 1 449 ? -5.570  -51.574 -24.694 1.00 20.88  ? 712  HIS   A CG  1 
ATOM   3267 N  ND1 . HIS   A 1 449 ? -5.729  -51.479 -23.336 1.00 21.42  ? 712  HIS   A ND1 1 
ATOM   3268 C  CD2 . HIS   A 1 449 ? -5.611  -52.887 -24.981 1.00 21.75  ? 712  HIS   A CD2 1 
ATOM   3269 C  CE1 . HIS   A 1 449 ? -5.921  -52.677 -22.833 1.00 21.77  ? 712  HIS   A CE1 1 
ATOM   3270 N  NE2 . HIS   A 1 449 ? -5.854  -53.561 -23.813 1.00 19.96  ? 712  HIS   A NE2 1 
ATOM   3271 N  N   . PHE   A 1 450 ? -7.251  -50.845 -27.812 1.00 21.60  ? 713  PHE   A N   1 
ATOM   3272 C  CA  . PHE   A 1 450 ? -8.139  -51.503 -28.772 1.00 21.58  ? 713  PHE   A CA  1 
ATOM   3273 C  C   . PHE   A 1 450 ? -7.426  -52.693 -29.410 1.00 22.81  ? 713  PHE   A C   1 
ATOM   3274 O  O   . PHE   A 1 450 ? -6.262  -52.557 -29.844 1.00 25.69  ? 713  PHE   A O   1 
ATOM   3275 C  CB  . PHE   A 1 450 ? -8.636  -50.460 -29.770 1.00 22.02  ? 713  PHE   A CB  1 
ATOM   3276 C  CG  . PHE   A 1 450 ? -9.377  -49.340 -29.086 1.00 23.99  ? 713  PHE   A CG  1 
ATOM   3277 C  CD1 . PHE   A 1 450 ? -8.696  -48.255 -28.569 1.00 23.91  ? 713  PHE   A CD1 1 
ATOM   3278 C  CD2 . PHE   A 1 450 ? -10.728 -49.430 -28.877 1.00 26.22  ? 713  PHE   A CD2 1 
ATOM   3279 C  CE1 . PHE   A 1 450 ? -9.376  -47.251 -27.885 1.00 24.64  ? 713  PHE   A CE1 1 
ATOM   3280 C  CE2 . PHE   A 1 450 ? -11.400 -48.433 -28.190 1.00 27.51  ? 713  PHE   A CE2 1 
ATOM   3281 C  CZ  . PHE   A 1 450 ? -10.716 -47.340 -27.708 1.00 24.29  ? 713  PHE   A CZ  1 
ATOM   3282 N  N   . HIS   A 1 451 ? -8.149  -53.807 -29.523 1.00 23.87  ? 714  HIS   A N   1 
ATOM   3283 C  CA  . HIS   A 1 451 ? -7.650  -55.042 -30.162 1.00 24.01  ? 714  HIS   A CA  1 
ATOM   3284 C  C   . HIS   A 1 451 ? -8.330  -55.249 -31.509 1.00 23.26  ? 714  HIS   A C   1 
ATOM   3285 O  O   . HIS   A 1 451 ? -9.541  -54.906 -31.666 1.00 25.92  ? 714  HIS   A O   1 
ATOM   3286 C  CB  . HIS   A 1 451 ? -7.874  -56.237 -29.224 1.00 24.91  ? 714  HIS   A CB  1 
ATOM   3287 C  CG  . HIS   A 1 451 ? -7.169  -56.200 -27.895 1.00 22.74  ? 714  HIS   A CG  1 
ATOM   3288 N  ND1 . HIS   A 1 451 ? -6.033  -56.899 -27.661 1.00 24.03  ? 714  HIS   A ND1 1 
ATOM   3289 C  CD2 . HIS   A 1 451 ? -7.506  -55.649 -26.699 1.00 26.18  ? 714  HIS   A CD2 1 
ATOM   3290 C  CE1 . HIS   A 1 451 ? -5.680  -56.778 -26.382 1.00 24.49  ? 714  HIS   A CE1 1 
ATOM   3291 N  NE2 . HIS   A 1 451 ? -6.543  -55.934 -25.771 1.00 18.38  ? 714  HIS   A NE2 1 
ATOM   3292 N  N   . GLU   A 1 452 ? -7.619  -55.881 -32.447 1.00 27.67  ? 715  GLU   A N   1 
ATOM   3293 C  CA  . GLU   A 1 452 ? -8.173  -56.377 -33.730 1.00 26.19  ? 715  GLU   A CA  1 
ATOM   3294 C  C   . GLU   A 1 452 ? -8.492  -57.877 -33.556 1.00 30.28  ? 715  GLU   A C   1 
ATOM   3295 O  O   . GLU   A 1 452 ? -7.661  -58.594 -33.088 1.00 30.97  ? 715  GLU   A O   1 
ATOM   3296 C  CB  . GLU   A 1 452 ? -7.177  -56.149 -34.874 1.00 31.76  ? 715  GLU   A CB  1 
ATOM   3297 C  CG  . GLU   A 1 452 ? -7.886  -55.848 -36.189 1.00 40.94  ? 715  GLU   A CG  1 
ATOM   3298 C  CD  . GLU   A 1 452 ? -6.975  -55.388 -37.339 1.00 48.73  ? 715  GLU   A CD  1 
ATOM   3299 O  OE1 . GLU   A 1 452 ? -7.423  -54.559 -38.195 1.00 44.85  ? 715  GLU   A OE1 1 
ATOM   3300 O  OE2 . GLU   A 1 452 ? -5.821  -55.865 -37.383 1.00 54.76  ? 715  GLU   A OE2 1 
ATOM   3301 N  N   . LEU   A 1 453 ? -9.738  -58.285 -33.680 1.00 25.26  ? 716  LEU   A N   1 
ATOM   3302 C  CA  . LEU   A 1 453 ? -10.182 -59.638 -33.257 1.00 29.55  ? 716  LEU   A CA  1 
ATOM   3303 C  C   . LEU   A 1 453 ? -10.880 -60.265 -34.445 1.00 33.22  ? 716  LEU   A C   1 
ATOM   3304 O  O   . LEU   A 1 453 ? -11.806 -59.644 -34.974 1.00 33.95  ? 716  LEU   A O   1 
ATOM   3305 C  CB  . LEU   A 1 453 ? -11.088 -59.426 -32.043 1.00 34.65  ? 716  LEU   A CB  1 
ATOM   3306 C  CG  . LEU   A 1 453 ? -11.851 -60.629 -31.539 1.00 41.22  ? 716  LEU   A CG  1 
ATOM   3307 C  CD1 . LEU   A 1 453 ? -10.900 -61.744 -31.181 1.00 46.14  ? 716  LEU   A CD1 1 
ATOM   3308 C  CD2 . LEU   A 1 453 ? -12.705 -60.212 -30.343 1.00 40.49  ? 716  LEU   A CD2 1 
ATOM   3309 N  N   . ILE   A 1 454 ? -10.364 -61.390 -34.924 1.00 33.77  ? 717  ILE   A N   1 
ATOM   3310 C  CA  . ILE   A 1 454 ? -10.857 -61.971 -36.193 1.00 35.34  ? 717  ILE   A CA  1 
ATOM   3311 C  C   . ILE   A 1 454 ? -11.865 -63.077 -35.857 1.00 34.48  ? 717  ILE   A C   1 
ATOM   3312 O  O   . ILE   A 1 454 ? -11.578 -63.921 -35.008 1.00 36.58  ? 717  ILE   A O   1 
ATOM   3313 C  CB  . ILE   A 1 454 ? -9.644  -62.413 -37.040 1.00 46.49  ? 717  ILE   A CB  1 
ATOM   3314 C  CG1 . ILE   A 1 454 ? -8.922  -61.171 -37.590 1.00 44.97  ? 717  ILE   A CG1 1 
ATOM   3315 C  CG2 . ILE   A 1 454 ? -10.056 -63.357 -38.168 1.00 51.19  ? 717  ILE   A CG2 1 
ATOM   3316 C  CD1 . ILE   A 1 454 ? -7.610  -61.482 -38.252 1.00 52.40  ? 717  ILE   A CD1 1 
ATOM   3317 N  N   . MET   A 1 455 ? -13.069 -62.941 -36.367 1.00 32.61  ? 718  MET   A N   1 
ATOM   3318 C  CA  . MET   A 1 455 ? -14.156 -63.920 -36.123 1.00 34.00  ? 718  MET   A CA  1 
ATOM   3319 C  C   . MET   A 1 455 ? -13.858 -65.191 -36.900 1.00 37.72  ? 718  MET   A C   1 
ATOM   3320 O  O   . MET   A 1 455 ? -13.203 -65.132 -37.974 1.00 35.47  ? 718  MET   A O   1 
ATOM   3321 C  CB  . MET   A 1 455 ? -15.506 -63.390 -36.592 1.00 34.01  ? 718  MET   A CB  1 
ATOM   3322 C  CG  . MET   A 1 455 ? -15.967 -62.231 -35.766 1.00 34.38  ? 718  MET   A CG  1 
ATOM   3323 S  SD  . MET   A 1 455 ? -17.502 -61.492 -36.320 1.00 39.52  ? 718  MET   A SD  1 
ATOM   3324 C  CE  . MET   A 1 455 ? -18.615 -62.826 -35.881 1.00 40.29  ? 718  MET   A CE  1 
ATOM   3325 N  N   A LYS   A 1 456 ? -14.338 -66.324 -36.386 0.25 38.38  ? 719  LYS   A N   1 
ATOM   3326 N  N   B LYS   A 1 456 ? -14.338 -66.325 -36.386 0.25 38.08  ? 719  LYS   A N   1 
ATOM   3327 C  CA  A LYS   A 1 456 ? -14.176 -67.655 -37.027 0.25 41.75  ? 719  LYS   A CA  1 
ATOM   3328 C  CA  B LYS   A 1 456 ? -14.171 -67.650 -37.038 0.25 41.21  ? 719  LYS   A CA  1 
ATOM   3329 C  C   A LYS   A 1 456 ? -14.587 -67.565 -38.503 0.25 40.25  ? 719  LYS   A C   1 
ATOM   3330 C  C   B LYS   A 1 456 ? -14.553 -67.529 -38.518 0.25 39.79  ? 719  LYS   A C   1 
ATOM   3331 O  O   A LYS   A 1 456 ? -13.962 -68.256 -39.320 0.25 41.60  ? 719  LYS   A O   1 
ATOM   3332 O  O   B LYS   A 1 456 ? -13.882 -68.161 -39.348 0.25 40.25  ? 719  LYS   A O   1 
ATOM   3333 C  CB  A LYS   A 1 456 ? -14.938 -68.720 -36.231 0.25 43.18  ? 719  LYS   A CB  1 
ATOM   3334 C  CB  B LYS   A 1 456 ? -14.986 -68.736 -36.330 0.25 42.44  ? 719  LYS   A CB  1 
ATOM   3335 C  CG  A LYS   A 1 456 ? -14.069 -69.496 -35.247 0.25 45.29  ? 719  LYS   A CG  1 
ATOM   3336 C  CG  B LYS   A 1 456 ? -14.563 -70.150 -36.706 0.25 44.42  ? 719  LYS   A CG  1 
ATOM   3337 C  CD  A LYS   A 1 456 ? -14.844 -70.316 -34.230 0.25 47.33  ? 719  LYS   A CD  1 
ATOM   3338 C  CD  B LYS   A 1 456 ? -15.185 -71.252 -35.884 0.25 45.16  ? 719  LYS   A CD  1 
ATOM   3339 C  CE  A LYS   A 1 456 ? -15.222 -69.527 -32.993 0.25 45.35  ? 719  LYS   A CE  1 
ATOM   3340 C  CE  B LYS   A 1 456 ? -15.324 -72.533 -36.680 0.25 45.44  ? 719  LYS   A CE  1 
ATOM   3341 N  NZ  A LYS   A 1 456 ? -16.619 -69.808 -32.584 0.25 44.01  ? 719  LYS   A NZ  1 
ATOM   3342 N  NZ  B LYS   A 1 456 ? -14.761 -73.695 -35.953 0.25 46.30  ? 719  LYS   A NZ  1 
ATOM   3343 N  N   . ASP   A 1 457 ? -15.548 -66.702 -38.844 1.00 39.39  ? 720  ASP   A N   1 
ATOM   3344 C  CA  . ASP   A 1 457 ? -15.998 -66.527 -40.246 1.00 40.82  ? 720  ASP   A CA  1 
ATOM   3345 C  C   . ASP   A 1 457 ? -15.163 -65.491 -41.019 1.00 53.26  ? 720  ASP   A C   1 
ATOM   3346 O  O   . ASP   A 1 457 ? -15.621 -65.086 -42.104 1.00 48.51  ? 720  ASP   A O   1 
ATOM   3347 C  CB  . ASP   A 1 457 ? -17.490 -66.191 -40.250 1.00 43.30  ? 720  ASP   A CB  1 
ATOM   3348 C  CG  . ASP   A 1 457 ? -17.855 -64.813 -39.728 1.00 44.78  ? 720  ASP   A CG  1 
ATOM   3349 O  OD1 . ASP   A 1 457 ? -17.005 -63.889 -39.812 1.00 41.44  ? 720  ASP   A OD1 1 
ATOM   3350 O  OD2 . ASP   A 1 457 ? -18.997 -64.674 -39.279 1.00 43.39  ? 720  ASP   A OD2 1 
ATOM   3351 N  N   . GLY   A 1 458 ? -14.026 -65.013 -40.489 1.00 49.82  ? 721  GLY   A N   1 
ATOM   3352 C  CA  . GLY   A 1 458 ? -13.142 -64.078 -41.211 1.00 41.17  ? 721  GLY   A CA  1 
ATOM   3353 C  C   . GLY   A 1 458 ? -13.453 -62.602 -41.000 1.00 40.05  ? 721  GLY   A C   1 
ATOM   3354 O  O   . GLY   A 1 458 ? -12.593 -61.786 -41.369 1.00 47.97  ? 721  GLY   A O   1 
ATOM   3355 N  N   . ARG   A 1 459 ? -14.624 -62.206 -40.479 1.00 33.90  ? 722  ARG   A N   1 
ATOM   3356 C  CA  . ARG   A 1 459 ? -14.956 -60.768 -40.396 1.00 31.83  ? 722  ARG   A CA  1 
ATOM   3357 C  C   . ARG   A 1 459 ? -14.110 -60.154 -39.251 1.00 33.70  ? 722  ARG   A C   1 
ATOM   3358 O  O   . ARG   A 1 459 ? -13.694 -60.894 -38.326 1.00 34.86  ? 722  ARG   A O   1 
ATOM   3359 C  CB  . ARG   A 1 459 ? -16.456 -60.557 -40.237 1.00 36.39  ? 722  ARG   A CB  1 
ATOM   3360 C  CG  . ARG   A 1 459 ? -17.304 -60.984 -41.437 1.00 37.78  ? 722  ARG   A CG  1 
ATOM   3361 C  CD  . ARG   A 1 459 ? -18.784 -60.684 -41.255 1.00 36.02  ? 722  ARG   A CD  1 
ATOM   3362 N  NE  . ARG   A 1 459 ? -19.373 -61.593 -40.296 1.00 33.49  ? 722  ARG   A NE  1 
ATOM   3363 C  CZ  . ARG   A 1 459 ? -20.645 -61.606 -40.001 1.00 32.18  ? 722  ARG   A CZ  1 
ATOM   3364 N  NH1 . ARG   A 1 459 ? -21.441 -60.691 -40.507 1.00 37.41  ? 722  ARG   A NH1 1 
ATOM   3365 N  NH2 . ARG   A 1 459 ? -21.106 -62.478 -39.122 1.00 36.62  ? 722  ARG   A NH2 1 
ATOM   3366 N  N   . VAL   A 1 460 ? -13.856 -58.852 -39.315 1.00 34.45  ? 723  VAL   A N   1 
ATOM   3367 C  CA  . VAL   A 1 460 ? -12.929 -58.177 -38.369 1.00 35.89  ? 723  VAL   A CA  1 
ATOM   3368 C  C   . VAL   A 1 460 ? -13.678 -57.320 -37.367 1.00 31.44  ? 723  VAL   A C   1 
ATOM   3369 O  O   . VAL   A 1 460 ? -14.398 -56.423 -37.757 1.00 38.19  ? 723  VAL   A O   1 
ATOM   3370 C  CB  . VAL   A 1 460 ? -11.820 -57.404 -39.086 1.00 37.13  ? 723  VAL   A CB  1 
ATOM   3371 C  CG1 . VAL   A 1 460 ? -10.879 -56.756 -38.069 1.00 39.52  ? 723  VAL   A CG1 1 
ATOM   3372 C  CG2 . VAL   A 1 460 ? -11.039 -58.370 -39.974 1.00 38.65  ? 723  VAL   A CG2 1 
ATOM   3373 N  N   . LEU   A 1 461 ? -13.463 -57.601 -36.068 1.00 28.04  ? 724  LEU   A N   1 
ATOM   3374 C  CA  . LEU   A 1 461 ? -13.958 -56.702 -35.014 1.00 26.27  ? 724  LEU   A CA  1 
ATOM   3375 C  C   . LEU   A 1 461 ? -12.776 -55.901 -34.435 1.00 26.69  ? 724  LEU   A C   1 
ATOM   3376 O  O   . LEU   A 1 461 ? -11.687 -56.446 -34.195 1.00 29.06  ? 724  LEU   A O   1 
ATOM   3377 C  CB  . LEU   A 1 461 ? -14.611 -57.530 -33.916 1.00 27.86  ? 724  LEU   A CB  1 
ATOM   3378 C  CG  . LEU   A 1 461 ? -15.767 -58.411 -34.347 1.00 27.87  ? 724  LEU   A CG  1 
ATOM   3379 C  CD1 . LEU   A 1 461 ? -16.089 -59.343 -33.231 1.00 31.57  ? 724  LEU   A CD1 1 
ATOM   3380 C  CD2 . LEU   A 1 461 ? -16.971 -57.588 -34.731 1.00 26.41  ? 724  LEU   A CD2 1 
ATOM   3381 N  N   . VAL   A 1 462 ? -12.999 -54.609 -34.206 0.25 25.52  ? 725  VAL   A N   1 
ATOM   3382 C  CA  . VAL   A 1 462 ? -12.069 -53.743 -33.426 0.25 24.44  ? 725  VAL   A CA  1 
ATOM   3383 C  C   . VAL   A 1 462 ? -12.749 -53.441 -32.091 0.25 23.66  ? 725  VAL   A C   1 
ATOM   3384 O  O   . VAL   A 1 462 ? -13.757 -52.712 -32.096 0.25 24.07  ? 725  VAL   A O   1 
ATOM   3385 C  CB  . VAL   A 1 462 ? -11.685 -52.464 -34.187 0.25 24.83  ? 725  VAL   A CB  1 
ATOM   3386 C  CG1 . VAL   A 1 462 ? -10.733 -51.610 -33.361 0.25 25.31  ? 725  VAL   A CG1 1 
ATOM   3387 C  CG2 . VAL   A 1 462 ? -11.079 -52.784 -35.544 0.25 24.90  ? 725  VAL   A CG2 1 
ATOM   3388 N  N   . VAL   A 1 463 ? -12.214 -53.993 -31.000 1.00 23.32  ? 726  VAL   A N   1 
ATOM   3389 C  CA  . VAL   A 1 463 ? -12.898 -54.002 -29.685 1.00 22.45  ? 726  VAL   A CA  1 
ATOM   3390 C  C   . VAL   A 1 463 ? -12.145 -53.176 -28.659 1.00 22.69  ? 726  VAL   A C   1 
ATOM   3391 O  O   . VAL   A 1 463 ? -10.918 -53.116 -28.690 1.00 22.92  ? 726  VAL   A O   1 
ATOM   3392 C  CB  . VAL   A 1 463 ? -13.067 -55.454 -29.232 1.00 22.79  ? 726  VAL   A CB  1 
ATOM   3393 C  CG1 . VAL   A 1 463 ? -13.923 -56.218 -30.245 1.00 24.53  ? 726  VAL   A CG1 1 
ATOM   3394 C  CG2 . VAL   A 1 463 ? -11.751 -56.167 -29.045 1.00 22.61  ? 726  VAL   A CG2 1 
ATOM   3395 N  N   . PRO   A 1 464 ? -12.903 -52.534 -27.740 1.00 22.51  ? 727  PRO   A N   1 
ATOM   3396 C  CA  . PRO   A 1 464 ? -12.315 -51.784 -26.628 1.00 21.07  ? 727  PRO   A CA  1 
ATOM   3397 C  C   . PRO   A 1 464 ? -11.877 -52.687 -25.483 1.00 21.91  ? 727  PRO   A C   1 
ATOM   3398 O  O   . PRO   A 1 464 ? -12.474 -53.777 -25.269 1.00 19.85  ? 727  PRO   A O   1 
ATOM   3399 C  CB  . PRO   A 1 464 ? -13.494 -50.913 -26.196 1.00 22.47  ? 727  PRO   A CB  1 
ATOM   3400 C  CG  . PRO   A 1 464 ? -14.723 -51.823 -26.432 1.00 24.59  ? 727  PRO   A CG  1 
ATOM   3401 C  CD  . PRO   A 1 464 ? -14.382 -52.500 -27.749 1.00 22.38  ? 727  PRO   A CD  1 
ATOM   3402 N  N   . CYS   A 1 465 ? -10.859 -52.254 -24.742 1.00 20.71  ? 728  CYS   A N   1 
ATOM   3403 C  CA  . CYS   A 1 465 ? -10.265 -53.095 -23.676 1.00 19.91  ? 728  CYS   A CA  1 
ATOM   3404 C  C   . CYS   A 1 465 ? -9.587  -52.235 -22.633 1.00 22.21  ? 728  CYS   A C   1 
ATOM   3405 O  O   . CYS   A 1 465 ? -9.095  -51.186 -22.959 1.00 22.60  ? 728  CYS   A O   1 
ATOM   3406 C  CB  . CYS   A 1 465 ? -9.251  -54.109 -24.245 1.00 22.33  ? 728  CYS   A CB  1 
ATOM   3407 S  SG  . CYS   A 1 465 ? -8.789  -55.464 -23.103 1.00 22.44  ? 728  CYS   A SG  1 
ATOM   3408 N  N   . ARG   A 1 466 ? -9.566  -52.699 -21.399 1.00 22.70  ? 729  ARG   A N   1 
ATOM   3409 C  CA  . ARG   A 1 466 ? -8.676  -52.105 -20.414 1.00 24.14  ? 729  ARG   A CA  1 
ATOM   3410 C  C   . ARG   A 1 466 ? -8.434  -53.150 -19.356 1.00 22.57  ? 729  ARG   A C   1 
ATOM   3411 O  O   . ARG   A 1 466 ? -9.045  -54.222 -19.387 1.00 22.06  ? 729  ARG   A O   1 
ATOM   3412 C  CB  . ARG   A 1 466 ? -9.252  -50.815 -19.857 1.00 32.14  ? 729  ARG   A CB  1 
ATOM   3413 C  CG  . ARG   A 1 466 ? -10.421 -51.018 -18.944 1.00 32.25  ? 729  ARG   A CG  1 
ATOM   3414 C  CD  . ARG   A 1 466 ? -11.205 -49.704 -18.819 1.00 29.54  ? 729  ARG   A CD  1 
ATOM   3415 N  NE  . ARG   A 1 466 ? -10.700 -48.901 -17.727 1.00 28.46  ? 729  ARG   A NE  1 
ATOM   3416 C  CZ  . ARG   A 1 466 ? -11.272 -47.767 -17.306 1.00 30.89  ? 729  ARG   A CZ  1 
ATOM   3417 N  NH1 . ARG   A 1 466 ? -12.449 -47.366 -17.770 1.00 31.36  ? 729  ARG   A NH1 1 
ATOM   3418 N  NH2 . ARG   A 1 466 ? -10.685 -47.093 -16.352 1.00 33.04  ? 729  ARG   A NH2 1 
ATOM   3419 N  N   . ASN   A 1 467 ? -7.500  -52.866 -18.491 1.00 22.37  ? 730  ASN   A N   1 
ATOM   3420 C  CA  . ASN   A 1 467 ? -7.115  -53.846 -17.449 1.00 22.53  ? 730  ASN   A CA  1 
ATOM   3421 C  C   . ASN   A 1 467 ? -8.396  -54.345 -16.734 1.00 21.07  ? 730  ASN   A C   1 
ATOM   3422 O  O   . ASN   A 1 467 ? -9.157  -53.548 -16.206 1.00 20.36  ? 730  ASN   A O   1 
ATOM   3423 C  CB  . ASN   A 1 467 ? -6.063  -53.242 -16.515 1.00 25.72  ? 730  ASN   A CB  1 
ATOM   3424 C  CG  . ASN   A 1 467 ? -5.736  -54.293 -15.470 1.00 29.56  ? 730  ASN   A CG  1 
ATOM   3425 O  OD1 . ASN   A 1 467 ? -6.438  -54.386 -14.480 1.00 28.79  ? 730  ASN   A OD1 1 
ATOM   3426 N  ND2 . ASN   A 1 467 ? -4.802  -55.188 -15.804 1.00 30.85  ? 730  ASN   A ND2 1 
ATOM   3427 N  N   . GLN   A 1 468 ? -8.557  -55.650 -16.569 1.00 21.20  ? 731  GLN   A N   1 
ATOM   3428 C  CA  . GLN   A 1 468 ? -9.847  -56.225 -16.142 1.00 22.61  ? 731  GLN   A CA  1 
ATOM   3429 C  C   . GLN   A 1 468 ? -10.072 -55.896 -14.667 1.00 21.65  ? 731  GLN   A C   1 
ATOM   3430 O  O   . GLN   A 1 468 ? -11.262 -55.823 -14.219 1.00 20.05  ? 731  GLN   A O   1 
ATOM   3431 C  CB  . GLN   A 1 468 ? -9.858  -57.701 -16.437 1.00 23.37  ? 731  GLN   A CB  1 
ATOM   3432 C  CG  . GLN   A 1 468 ? -11.237 -58.312 -16.337 1.00 23.75  ? 731  GLN   A CG  1 
ATOM   3433 C  CD  . GLN   A 1 468 ? -11.194 -59.806 -16.478 1.00 24.60  ? 731  GLN   A CD  1 
ATOM   3434 O  OE1 . GLN   A 1 468 ? -11.509 -60.332 -17.537 1.00 25.52  ? 731  GLN   A OE1 1 
ATOM   3435 N  NE2 . GLN   A 1 468 ? -10.853 -60.489 -15.403 1.00 21.10  ? 731  GLN   A NE2 1 
ATOM   3436 N  N   . ASP   A 1 469 ? -8.999  -55.713 -13.911 1.00 23.15  ? 732  ASP   A N   1 
ATOM   3437 C  CA  . ASP   A 1 469 ? -9.170  -55.328 -12.476 1.00 24.57  ? 732  ASP   A CA  1 
ATOM   3438 C  C   . ASP   A 1 469 ? -9.954  -54.015 -12.387 1.00 26.64  ? 732  ASP   A C   1 
ATOM   3439 O  O   . ASP   A 1 469 ? -10.736 -53.834 -11.418 1.00 25.91  ? 732  ASP   A O   1 
ATOM   3440 C  CB  . ASP   A 1 469 ? -7.844  -55.217 -11.719 1.00 25.67  ? 732  ASP   A CB  1 
ATOM   3441 C  CG  . ASP   A 1 469 ? -7.142  -56.561 -11.527 1.00 29.65  ? 732  ASP   A CG  1 
ATOM   3442 O  OD1 . ASP   A 1 469 ? -7.801  -57.600 -11.656 1.00 26.06  ? 732  ASP   A OD1 1 
ATOM   3443 O  OD2 . ASP   A 1 469 ? -5.934  -56.543 -11.241 1.00 33.93  ? 732  ASP   A OD2 1 
ATOM   3444 N  N   . GLU   A 1 470 ? -9.687  -53.059 -13.278 1.00 24.35  ? 733  GLU   A N   1 
ATOM   3445 C  CA  . GLU   A 1 470 ? -10.361 -51.733 -13.272 1.00 24.78  ? 733  GLU   A CA  1 
ATOM   3446 C  C   . GLU   A 1 470 ? -11.852 -51.959 -13.587 1.00 23.13  ? 733  GLU   A C   1 
ATOM   3447 O  O   . GLU   A 1 470 ? -12.709 -51.299 -12.988 1.00 23.72  ? 733  GLU   A O   1 
ATOM   3448 C  CB  . GLU   A 1 470 ? -9.823  -50.803 -14.360 1.00 25.78  ? 733  GLU   A CB  1 
ATOM   3449 C  CG  . GLU   A 1 470 ? -8.333  -50.504 -14.237 1.00 32.53  ? 733  GLU   A CG  1 
ATOM   3450 C  CD  . GLU   A 1 470 ? -7.728  -49.743 -15.431 1.00 35.54  ? 733  GLU   A CD  1 
ATOM   3451 O  OE1 . GLU   A 1 470 ? -6.508  -49.729 -15.543 1.00 43.97  ? 733  GLU   A OE1 1 
ATOM   3452 O  OE2 . GLU   A 1 470 ? -8.483  -49.210 -16.283 1.00 36.55  ? 733  GLU   A OE2 1 
ATOM   3453 N  N   . LEU   A 1 471 ? -12.181 -52.861 -14.510 1.00 22.09  ? 734  LEU   A N   1 
ATOM   3454 C  CA  . LEU   A 1 471 ? -13.594 -53.063 -14.894 1.00 21.48  ? 734  LEU   A CA  1 
ATOM   3455 C  C   . LEU   A 1 471 ? -14.374 -53.684 -13.726 1.00 21.68  ? 734  LEU   A C   1 
ATOM   3456 O  O   . LEU   A 1 471 ? -15.506 -53.177 -13.359 1.00 22.05  ? 734  LEU   A O   1 
ATOM   3457 C  CB  . LEU   A 1 471 ? -13.647 -53.892 -16.158 1.00 22.78  ? 734  LEU   A CB  1 
ATOM   3458 C  CG  . LEU   A 1 471 ? -13.110 -53.147 -17.375 1.00 24.62  ? 734  LEU   A CG  1 
ATOM   3459 C  CD1 . LEU   A 1 471 ? -12.965 -54.090 -18.532 1.00 22.47  ? 734  LEU   A CD1 1 
ATOM   3460 C  CD2 . LEU   A 1 471 ? -14.062 -52.012 -17.758 1.00 24.34  ? 734  LEU   A CD2 1 
ATOM   3461 N  N   . ILE   A 1 472 ? -13.809 -54.725 -13.137 1.00 24.40  ? 735  ILE   A N   1 
ATOM   3462 C  CA  . ILE   A 1 472 ? -14.487 -55.443 -12.039 1.00 24.21  ? 735  ILE   A CA  1 
ATOM   3463 C  C   . ILE   A 1 472 ? -14.600 -54.554 -10.818 1.00 22.63  ? 735  ILE   A C   1 
ATOM   3464 O  O   . ILE   A 1 472 ? -15.667 -54.587 -10.174 1.00 23.05  ? 735  ILE   A O   1 
ATOM   3465 C  CB  . ILE   A 1 472 ? -13.771 -56.748 -11.737 1.00 22.88  ? 735  ILE   A CB  1 
ATOM   3466 C  CG1 . ILE   A 1 472 ? -13.994 -57.659 -12.933 1.00 24.81  ? 735  ILE   A CG1 1 
ATOM   3467 C  CG2 . ILE   A 1 472 ? -14.267 -57.293 -10.414 1.00 23.62  ? 735  ILE   A CG2 1 
ATOM   3468 C  CD1 . ILE   A 1 472 ? -13.251 -58.932 -12.891 1.00 29.40  ? 735  ILE   A CD1 1 
ATOM   3469 N  N   . GLY   A 1 473 ? -13.544 -53.819 -10.514 1.00 21.51  ? 736  GLY   A N   1 
ATOM   3470 C  CA  . GLY   A 1 473 ? -13.519 -52.915 -9.361  1.00 24.29  ? 736  GLY   A CA  1 
ATOM   3471 C  C   . GLY   A 1 473 ? -14.589 -51.814 -9.473  1.00 26.20  ? 736  GLY   A C   1 
ATOM   3472 O  O   . GLY   A 1 473 ? -15.259 -51.487 -8.445  1.00 22.32  ? 736  GLY   A O   1 
ATOM   3473 N  N   . ARG   A 1 474 ? -14.795 -51.273 -10.677 0.25 25.11  ? 737  ARG   A N   1 
ATOM   3474 C  CA  . ARG   A 1 474 ? -15.802 -50.205 -10.937 0.25 26.09  ? 737  ARG   A CA  1 
ATOM   3475 C  C   . ARG   A 1 474 ? -17.222 -50.761 -10.771 0.25 25.17  ? 737  ARG   A C   1 
ATOM   3476 O  O   . ARG   A 1 474 ? -18.050 -50.073 -10.147 0.25 25.42  ? 737  ARG   A O   1 
ATOM   3477 C  CB  . ARG   A 1 474 ? -15.638 -49.631 -12.348 0.25 28.17  ? 737  ARG   A CB  1 
ATOM   3478 C  CG  . ARG   A 1 474 ? -14.317 -48.910 -12.565 0.25 31.51  ? 737  ARG   A CG  1 
ATOM   3479 C  CD  . ARG   A 1 474 ? -13.998 -48.689 -14.036 0.25 34.40  ? 737  ARG   A CD  1 
ATOM   3480 N  NE  . ARG   A 1 474 ? -14.409 -47.351 -14.438 0.25 35.98  ? 737  ARG   A NE  1 
ATOM   3481 C  CZ  . ARG   A 1 474 ? -13.776 -46.233 -14.091 0.25 36.78  ? 737  ARG   A CZ  1 
ATOM   3482 N  NH1 . ARG   A 1 474 ? -14.235 -45.064 -14.510 0.25 38.48  ? 737  ARG   A NH1 1 
ATOM   3483 N  NH2 . ARG   A 1 474 ? -12.693 -46.282 -13.332 0.25 35.63  ? 737  ARG   A NH2 1 
ATOM   3484 N  N   . ALA   A 1 475 ? -17.489 -51.955 -11.312 1.00 24.30  ? 738  ALA   A N   1 
ATOM   3485 C  CA  . ALA   A 1 475 ? -18.837 -52.587 -11.289 1.00 23.01  ? 738  ALA   A CA  1 
ATOM   3486 C  C   . ALA   A 1 475 ? -19.234 -52.926 -9.849  1.00 25.86  ? 738  ALA   A C   1 
ATOM   3487 O  O   . ALA   A 1 475 ? -20.434 -53.003 -9.582  1.00 26.36  ? 738  ALA   A O   1 
ATOM   3488 C  CB  . ALA   A 1 475 ? -18.840 -53.804 -12.143 1.00 21.39  ? 738  ALA   A CB  1 
ATOM   3489 N  N   . ARG   A 1 476 ? -18.250 -53.109 -8.964  1.00 25.17  ? 739  ARG   A N   1 
ATOM   3490 C  CA  . ARG   A 1 476 ? -18.518 -53.425 -7.529  1.00 24.21  ? 739  ARG   A CA  1 
ATOM   3491 C  C   . ARG   A 1 476 ? -18.852 -52.180 -6.685  1.00 25.77  ? 739  ARG   A C   1 
ATOM   3492 O  O   . ARG   A 1 476 ? -19.187 -52.362 -5.495  1.00 26.51  ? 739  ARG   A O   1 
ATOM   3493 C  CB  . ARG   A 1 476 ? -17.372 -54.235 -6.928  1.00 23.27  ? 739  ARG   A CB  1 
ATOM   3494 C  CG  . ARG   A 1 476 ? -17.345 -55.648 -7.499  1.00 24.53  ? 739  ARG   A CG  1 
ATOM   3495 C  CD  . ARG   A 1 476 ? -16.038 -56.454 -7.366  1.00 26.75  ? 739  ARG   A CD  1 
ATOM   3496 N  NE  . ARG   A 1 476 ? -15.600 -56.666 -6.019  1.00 25.63  ? 739  ARG   A NE  1 
ATOM   3497 C  CZ  . ARG   A 1 476 ? -15.282 -57.820 -5.436  1.00 22.48  ? 739  ARG   A CZ  1 
ATOM   3498 N  NH1 . ARG   A 1 476 ? -15.417 -58.992 -6.009  1.00 26.05  ? 739  ARG   A NH1 1 
ATOM   3499 N  NH2 . ARG   A 1 476 ? -14.784 -57.781 -4.225  1.00 26.02  ? 739  ARG   A NH2 1 
ATOM   3500 N  N   . ILE   A 1 477 ? -18.881 -50.987 -7.285  1.00 27.28  ? 740  ILE   A N   1 
ATOM   3501 C  CA  . ILE   A 1 477 ? -19.123 -49.728 -6.539  1.00 35.42  ? 740  ILE   A CA  1 
ATOM   3502 C  C   . ILE   A 1 477 ? -20.451 -49.126 -6.988  1.00 38.74  ? 740  ILE   A C   1 
ATOM   3503 O  O   . ILE   A 1 477 ? -20.749 -49.106 -8.186  1.00 33.75  ? 740  ILE   A O   1 
ATOM   3504 C  CB  . ILE   A 1 477 ? -17.966 -48.730 -6.745  1.00 34.74  ? 740  ILE   A CB  1 
ATOM   3505 C  CG1 . ILE   A 1 477 ? -16.677 -49.227 -6.084  1.00 38.37  ? 740  ILE   A CG1 1 
ATOM   3506 C  CG2 . ILE   A 1 477 ? -18.356 -47.357 -6.228  1.00 42.93  ? 740  ILE   A CG2 1 
ATOM   3507 C  CD1 . ILE   A 1 477 ? -15.452 -48.366 -6.405  1.00 39.88  ? 740  ILE   A CD1 1 
ATOM   3508 N  N   A SER   A 1 478 ? -21.241 -48.677 -6.016  0.12 40.57  ? 741  SER   A N   1 
ATOM   3509 N  N   B SER   A 1 478 ? -21.255 -48.677 -6.019  0.13 41.29  ? 741  SER   A N   1 
ATOM   3510 C  CA  A SER   A 1 478 ? -22.410 -47.777 -6.198  0.12 44.47  ? 741  SER   A CA  1 
ATOM   3511 C  CA  B SER   A 1 478 ? -22.437 -47.791 -6.216  0.13 45.66  ? 741  SER   A CA  1 
ATOM   3512 C  C   A SER   A 1 478 ? -22.055 -46.399 -5.624  0.12 47.99  ? 741  SER   A C   1 
ATOM   3513 C  C   B SER   A 1 478 ? -22.233 -46.480 -5.439  0.13 48.99  ? 741  SER   A C   1 
ATOM   3514 O  O   A SER   A 1 478 ? -21.006 -46.283 -4.943  0.12 48.52  ? 741  SER   A O   1 
ATOM   3515 O  O   B SER   A 1 478 ? -21.487 -46.486 -4.429  0.13 49.03  ? 741  SER   A O   1 
ATOM   3516 C  CB  A SER   A 1 478 ? -23.641 -48.374 -5.551  0.12 43.76  ? 741  SER   A CB  1 
ATOM   3517 C  CB  B SER   A 1 478 ? -23.741 -48.481 -5.839  0.13 45.70  ? 741  SER   A CB  1 
ATOM   3518 O  OG  A SER   A 1 478 ? -24.725 -47.457 -5.532  0.12 42.45  ? 741  SER   A OG  1 
ATOM   3519 O  OG  B SER   A 1 478 ? -23.554 -49.515 -4.878  0.13 45.63  ? 741  SER   A OG  1 
ATOM   3520 N  N   . GLN   A 1 479 ? -22.887 -45.392 -5.893  0.25 52.20  ? 742  GLN   A N   1 
ATOM   3521 C  CA  . GLN   A 1 479 ? -22.754 -44.024 -5.321  0.25 55.97  ? 742  GLN   A CA  1 
ATOM   3522 C  C   . GLN   A 1 479 ? -24.109 -43.596 -4.749  0.25 57.27  ? 742  GLN   A C   1 
ATOM   3523 O  O   . GLN   A 1 479 ? -25.122 -43.789 -5.448  0.25 55.36  ? 742  GLN   A O   1 
ATOM   3524 C  CB  . GLN   A 1 479 ? -22.288 -43.027 -6.385  0.25 57.38  ? 742  GLN   A CB  1 
ATOM   3525 C  CG  . GLN   A 1 479 ? -21.017 -43.441 -7.117  0.25 59.58  ? 742  GLN   A CG  1 
ATOM   3526 C  CD  . GLN   A 1 479 ? -19.776 -43.397 -6.255  0.25 60.07  ? 742  GLN   A CD  1 
ATOM   3527 O  OE1 . GLN   A 1 479 ? -19.762 -42.820 -5.168  0.25 59.18  ? 742  GLN   A OE1 1 
ATOM   3528 N  NE2 . GLN   A 1 479 ? -18.708 -44.004 -6.746  0.25 60.90  ? 742  GLN   A NE2 1 
ATOM   3529 N  N   . GLY   A 1 480 ? -24.114 -43.024 -3.539  1.00 59.74  ? 743  GLY   A N   1 
ATOM   3530 C  CA  . GLY   A 1 480 ? -25.340 -42.496 -2.901  1.00 61.60  ? 743  GLY   A CA  1 
ATOM   3531 C  C   . GLY   A 1 480 ? -26.058 -43.482 -1.993  1.00 55.08  ? 743  GLY   A C   1 
ATOM   3532 O  O   . GLY   A 1 480 ? -25.636 -44.617 -1.848  1.00 49.19  ? 743  GLY   A O   1 
ATOM   3533 N  N   . ALA   A 1 481 ? -27.140 -43.017 -1.376  1.00 57.32  ? 744  ALA   A N   1 
ATOM   3534 C  CA  . ALA   A 1 481 ? -27.824 -43.690 -0.256  1.00 53.60  ? 744  ALA   A CA  1 
ATOM   3535 C  C   . ALA   A 1 481 ? -29.186 -44.209 -0.718  1.00 47.15  ? 744  ALA   A C   1 
ATOM   3536 O  O   . ALA   A 1 481 ? -29.640 -43.817 -1.784  1.00 42.24  ? 744  ALA   A O   1 
ATOM   3537 C  CB  . ALA   A 1 481 ? -27.967 -42.706 0.892   1.00 58.00  ? 744  ALA   A CB  1 
ATOM   3538 N  N   . GLY   A 1 482 ? -29.814 -45.031 0.120   1.00 43.00  ? 745  GLY   A N   1 
ATOM   3539 C  CA  . GLY   A 1 482 ? -31.225 -45.429 0.011   1.00 39.98  ? 745  GLY   A CA  1 
ATOM   3540 C  C   . GLY   A 1 482 ? -31.405 -46.411 -1.117  1.00 39.74  ? 745  GLY   A C   1 
ATOM   3541 O  O   . GLY   A 1 482 ? -32.474 -46.387 -1.708  1.00 45.61  ? 745  GLY   A O   1 
ATOM   3542 N  N   . TRP   A 1 483 ? -30.364 -47.187 -1.489  1.00 31.38  ? 746  TRP   A N   1 
ATOM   3543 C  CA  . TRP   A 1 483 ? -30.552 -48.200 -2.560  1.00 31.97  ? 746  TRP   A CA  1 
ATOM   3544 C  C   . TRP   A 1 483 ? -31.347 -49.406 -2.018  1.00 30.05  ? 746  TRP   A C   1 
ATOM   3545 O  O   . TRP   A 1 483 ? -30.883 -50.103 -1.123  1.00 28.90  ? 746  TRP   A O   1 
ATOM   3546 C  CB  . TRP   A 1 483 ? -29.233 -48.616 -3.178  1.00 37.99  ? 746  TRP   A CB  1 
ATOM   3547 C  CG  . TRP   A 1 483 ? -28.500 -47.600 -3.996  1.00 44.98  ? 746  TRP   A CG  1 
ATOM   3548 C  CD1 . TRP   A 1 483 ? -27.758 -46.547 -3.527  1.00 57.97  ? 746  TRP   A CD1 1 
ATOM   3549 C  CD2 . TRP   A 1 483 ? -28.303 -47.617 -5.419  1.00 44.22  ? 746  TRP   A CD2 1 
ATOM   3550 N  NE1 . TRP   A 1 483 ? -27.174 -45.863 -4.565  1.00 51.54  ? 746  TRP   A NE1 1 
ATOM   3551 C  CE2 . TRP   A 1 483 ? -27.491 -46.502 -5.739  1.00 53.19  ? 746  TRP   A CE2 1 
ATOM   3552 C  CE3 . TRP   A 1 483 ? -28.763 -48.438 -6.454  1.00 38.10  ? 746  TRP   A CE3 1 
ATOM   3553 C  CZ2 . TRP   A 1 483 ? -27.128 -46.210 -7.055  1.00 47.81  ? 746  TRP   A CZ2 1 
ATOM   3554 C  CZ3 . TRP   A 1 483 ? -28.404 -48.151 -7.749  1.00 39.60  ? 746  TRP   A CZ3 1 
ATOM   3555 C  CH2 . TRP   A 1 483 ? -27.623 -47.034 -8.043  1.00 44.23  ? 746  TRP   A CH2 1 
ATOM   3556 N  N   . SER   A 1 484 ? -32.474 -49.744 -2.623  1.00 29.10  ? 747  SER   A N   1 
ATOM   3557 C  CA  . SER   A 1 484 ? -33.152 -51.047 -2.362  1.00 26.46  ? 747  SER   A CA  1 
ATOM   3558 C  C   . SER   A 1 484 ? -32.314 -52.204 -2.900  1.00 22.10  ? 747  SER   A C   1 
ATOM   3559 O  O   . SER   A 1 484 ? -31.428 -51.922 -3.724  1.00 24.90  ? 747  SER   A O   1 
ATOM   3560 C  CB  . SER   A 1 484 ? -34.550 -51.046 -2.945  1.00 28.00  ? 747  SER   A CB  1 
ATOM   3561 O  OG  . SER   A 1 484 ? -34.518 -51.059 -4.362  1.00 25.65  ? 747  SER   A OG  1 
ATOM   3562 N  N   . LEU   A 1 485 ? -32.659 -53.468 -2.573  1.00 23.92  ? 748  LEU   A N   1 
ATOM   3563 C  CA  . LEU   A 1 485 ? -32.025 -54.649 -3.203  1.00 23.50  ? 748  LEU   A CA  1 
ATOM   3564 C  C   . LEU   A 1 485 ? -32.344 -54.675 -4.717  1.00 29.01  ? 748  LEU   A C   1 
ATOM   3565 O  O   . LEU   A 1 485 ? -31.420 -54.871 -5.572  1.00 24.13  ? 748  LEU   A O   1 
ATOM   3566 C  CB  . LEU   A 1 485 ? -32.539 -55.912 -2.526  1.00 27.56  ? 748  LEU   A CB  1 
ATOM   3567 C  CG  . LEU   A 1 485 ? -31.916 -57.205 -3.040  1.00 30.69  ? 748  LEU   A CG  1 
ATOM   3568 C  CD1 . LEU   A 1 485 ? -30.403 -57.045 -3.090  1.00 31.55  ? 748  LEU   A CD1 1 
ATOM   3569 C  CD2 . LEU   A 1 485 ? -32.309 -58.372 -2.184  1.00 31.74  ? 748  LEU   A CD2 1 
ATOM   3570 N  N   . ARG   A 1 486 ? -33.571 -54.299 -5.087  1.00 26.60  ? 749  ARG   A N   1 
ATOM   3571 C  CA  . ARG   A 1 486 ? -33.983 -54.294 -6.509  1.00 25.30  ? 749  ARG   A CA  1 
ATOM   3572 C  C   . ARG   A 1 486 ? -33.148 -53.260 -7.246  1.00 26.53  ? 749  ARG   A C   1 
ATOM   3573 O  O   . ARG   A 1 486 ? -32.688 -53.562 -8.318  1.00 24.98  ? 749  ARG   A O   1 
ATOM   3574 C  CB  . ARG   A 1 486 ? -35.471 -53.992 -6.639  1.00 29.05  ? 749  ARG   A CB  1 
ATOM   3575 C  CG  . ARG   A 1 486 ? -35.912 -53.770 -8.079  1.00 32.79  ? 749  ARG   A CG  1 
ATOM   3576 C  CD  . ARG   A 1 486 ? -37.418 -53.869 -8.137  1.00 32.93  ? 749  ARG   A CD  1 
ATOM   3577 N  NE  . ARG   A 1 486 ? -37.933 -53.710 -9.509  1.00 29.93  ? 749  ARG   A NE  1 
ATOM   3578 C  CZ  . ARG   A 1 486 ? -39.043 -54.281 -9.909  1.00 31.86  ? 749  ARG   A CZ  1 
ATOM   3579 N  NH1 . ARG   A 1 486 ? -39.732 -54.999 -9.024  1.00 30.38  ? 749  ARG   A NH1 1 
ATOM   3580 N  NH2 . ARG   A 1 486 ? -39.467 -54.119 -11.155 1.00 32.29  ? 749  ARG   A NH2 1 
ATOM   3581 N  N   . GLU   A 1 487 ? -33.032 -52.031 -6.740  1.00 25.23  ? 750  GLU   A N   1 
ATOM   3582 C  CA  . GLU   A 1 487 ? -32.215 -51.030 -7.450  1.00 27.95  ? 750  GLU   A CA  1 
ATOM   3583 C  C   . GLU   A 1 487 ? -30.736 -51.491 -7.565  1.00 27.21  ? 750  GLU   A C   1 
ATOM   3584 O  O   . GLU   A 1 487 ? -30.101 -51.266 -8.642  1.00 21.46  ? 750  GLU   A O   1 
ATOM   3585 C  CB  . GLU   A 1 487 ? -32.327 -49.670 -6.761  1.00 34.93  ? 750  GLU   A CB  1 
ATOM   3586 C  CG  . GLU   A 1 487 ? -32.068 -48.532 -7.732  1.00 44.77  ? 750  GLU   A CG  1 
ATOM   3587 C  CD  . GLU   A 1 487 ? -31.956 -47.115 -7.174  1.00 53.26  ? 750  GLU   A CD  1 
ATOM   3588 O  OE1 . GLU   A 1 487 ? -32.219 -46.934 -5.941  1.00 50.57  ? 750  GLU   A OE1 1 
ATOM   3589 O  OE2 . GLU   A 1 487 ? -31.617 -46.186 -7.991  1.00 51.47  ? 750  GLU   A OE2 1 
ATOM   3590 N  N   . THR   A 1 488 ? -30.166 -52.071 -6.503  1.00 25.86  ? 751  THR   A N   1 
ATOM   3591 C  CA  . THR   A 1 488 ? -28.765 -52.581 -6.532  1.00 24.98  ? 751  THR   A CA  1 
ATOM   3592 C  C   . THR   A 1 488 ? -28.645 -53.636 -7.641  1.00 23.95  ? 751  THR   A C   1 
ATOM   3593 O  O   . THR   A 1 488 ? -27.604 -53.606 -8.440  1.00 25.50  ? 751  THR   A O   1 
ATOM   3594 C  CB  . THR   A 1 488 ? -28.356 -53.137 -5.175  1.00 25.78  ? 751  THR   A CB  1 
ATOM   3595 O  OG1 . THR   A 1 488 ? -28.568 -52.077 -4.248  1.00 25.16  ? 751  THR   A OG1 1 
ATOM   3596 C  CG2 . THR   A 1 488 ? -26.938 -53.678 -5.150  1.00 24.47  ? 751  THR   A CG2 1 
ATOM   3597 N  N   . ALA   A 1 489 ? -29.581 -54.593 -7.682  1.00 24.79  ? 752  ALA   A N   1 
ATOM   3598 C  CA  . ALA   A 1 489 ? -29.634 -55.631 -8.726  1.00 24.83  ? 752  ALA   A CA  1 
ATOM   3599 C  C   . ALA   A 1 489 ? -29.660 -54.984 -10.117 1.00 27.07  ? 752  ALA   A C   1 
ATOM   3600 O  O   . ALA   A 1 489 ? -28.941 -55.499 -11.029 1.00 24.15  ? 752  ALA   A O   1 
ATOM   3601 C  CB  . ALA   A 1 489 ? -30.823 -56.542 -8.512  1.00 24.85  ? 752  ALA   A CB  1 
ATOM   3602 N  N   . CYS   A 1 490 ? -30.504 -53.951 -10.320 1.00 23.45  ? 753  CYS   A N   1 
ATOM   3603 C  CA  . CYS   A 1 490 ? -30.697 -53.360 -11.673 1.00 23.37  ? 753  CYS   A CA  1 
ATOM   3604 C  C   . CYS   A 1 490 ? -29.398 -52.627 -12.077 1.00 23.40  ? 753  CYS   A C   1 
ATOM   3605 O  O   . CYS   A 1 490 ? -29.059 -52.655 -13.254 1.00 23.42  ? 753  CYS   A O   1 
ATOM   3606 C  CB  . CYS   A 1 490 ? -31.942 -52.474 -11.722 1.00 25.18  ? 753  CYS   A CB  1 
ATOM   3607 S  SG  . CYS   A 1 490 ? -33.471 -53.478 -11.625 1.00 29.31  ? 753  CYS   A SG  1 
ATOM   3608 N  N   . LEU   A 1 491 ? -28.676 -52.003 -11.143 1.00 21.52  ? 754  LEU   A N   1 
ATOM   3609 C  CA  . LEU   A 1 491 ? -27.317 -51.458 -11.442 1.00 22.35  ? 754  LEU   A CA  1 
ATOM   3610 C  C   . LEU   A 1 491 ? -26.320 -52.576 -11.807 1.00 23.65  ? 754  LEU   A C   1 
ATOM   3611 O  O   . LEU   A 1 491 ? -25.584 -52.467 -12.786 1.00 24.95  ? 754  LEU   A O   1 
ATOM   3612 C  CB  . LEU   A 1 491 ? -26.873 -50.610 -10.247 1.00 26.63  ? 754  LEU   A CB  1 
ATOM   3613 C  CG  . LEU   A 1 491 ? -25.520 -49.947 -10.466 1.00 28.72  ? 754  LEU   A CG  1 
ATOM   3614 C  CD1 . LEU   A 1 491 ? -25.579 -48.998 -11.636 1.00 28.58  ? 754  LEU   A CD1 1 
ATOM   3615 C  CD2 . LEU   A 1 491 ? -25.006 -49.271 -9.229  1.00 28.89  ? 754  LEU   A CD2 1 
ATOM   3616 N  N   . GLY   A 1 492 ? -26.338 -53.701 -11.107 1.00 22.57  ? 755  GLY   A N   1 
ATOM   3617 C  CA  . GLY   A 1 492 ? -25.452 -54.806 -11.486 1.00 20.22  ? 755  GLY   A CA  1 
ATOM   3618 C  C   . GLY   A 1 492 ? -25.755 -55.272 -12.881 1.00 22.61  ? 755  GLY   A C   1 
ATOM   3619 O  O   . GLY   A 1 492 ? -24.816 -55.531 -13.682 1.00 21.01  ? 755  GLY   A O   1 
ATOM   3620 N  N   . LYS   A 1 493 ? -27.043 -55.325 -13.206 1.00 22.66  ? 756  LYS   A N   1 
ATOM   3621 C  CA  . LYS   A 1 493 ? -27.491 -55.709 -14.567 1.00 23.34  ? 756  LYS   A CA  1 
ATOM   3622 C  C   . LYS   A 1 493 ? -26.987 -54.734 -15.608 1.00 20.84  ? 756  LYS   A C   1 
ATOM   3623 O  O   . LYS   A 1 493 ? -26.613 -55.244 -16.681 1.00 24.53  ? 756  LYS   A O   1 
ATOM   3624 C  CB  . LYS   A 1 493 ? -29.017 -55.831 -14.664 1.00 25.22  ? 756  LYS   A CB  1 
ATOM   3625 C  CG  . LYS   A 1 493 ? -29.528 -56.389 -15.985 1.00 27.51  ? 756  LYS   A CG  1 
ATOM   3626 C  CD  . LYS   A 1 493 ? -30.955 -56.877 -15.838 1.00 26.86  ? 756  LYS   A CD  1 
ATOM   3627 C  CE  . LYS   A 1 493 ? -31.614 -57.209 -17.151 1.00 29.38  ? 756  LYS   A CE  1 
ATOM   3628 N  NZ  . LYS   A 1 493 ? -32.958 -57.779 -16.905 1.00 30.55  ? 756  LYS   A NZ  1 
ATOM   3629 N  N   . SER   A 1 494 ? -26.997 -53.422 -15.372 1.00 23.26  ? 757  SER   A N   1 
ATOM   3630 C  CA  . SER   A 1 494 ? -26.430 -52.456 -16.333 1.00 24.68  ? 757  SER   A CA  1 
ATOM   3631 C  C   . SER   A 1 494 ? -24.956 -52.808 -16.597 1.00 24.50  ? 757  SER   A C   1 
ATOM   3632 O  O   . SER   A 1 494 ? -24.581 -52.779 -17.768 1.00 21.18  ? 757  SER   A O   1 
ATOM   3633 C  CB  . SER   A 1 494 ? -26.493 -51.005 -15.929 1.00 31.08  ? 757  SER   A CB  1 
ATOM   3634 O  OG  . SER   A 1 494 ? -27.794 -50.654 -15.469 1.00 39.12  ? 757  SER   A OG  1 
ATOM   3635 N  N   . TYR   A 1 495 ? -24.135 -53.016 -15.570 1.00 21.78  ? 758  TYR   A N   1 
ATOM   3636 C  CA  . TYR   A 1 495 ? -22.702 -53.364 -15.777 1.00 23.30  ? 758  TYR   A CA  1 
ATOM   3637 C  C   . TYR   A 1 495 ? -22.610 -54.642 -16.586 1.00 21.48  ? 758  TYR   A C   1 
ATOM   3638 O  O   . TYR   A 1 495 ? -21.794 -54.789 -17.530 1.00 23.20  ? 758  TYR   A O   1 
ATOM   3639 C  CB  . TYR   A 1 495 ? -21.960 -53.500 -14.442 1.00 22.26  ? 758  TYR   A CB  1 
ATOM   3640 C  CG  . TYR   A 1 495 ? -21.488 -52.187 -13.928 1.00 21.44  ? 758  TYR   A CG  1 
ATOM   3641 C  CD1 . TYR   A 1 495 ? -20.371 -51.573 -14.500 1.00 22.92  ? 758  TYR   A CD1 1 
ATOM   3642 C  CD2 . TYR   A 1 495 ? -22.167 -51.511 -12.933 1.00 23.78  ? 758  TYR   A CD2 1 
ATOM   3643 C  CE1 . TYR   A 1 495 ? -19.941 -50.330 -14.065 1.00 23.78  ? 758  TYR   A CE1 1 
ATOM   3644 C  CE2 . TYR   A 1 495 ? -21.728 -50.261 -12.490 1.00 26.61  ? 758  TYR   A CE2 1 
ATOM   3645 C  CZ  . TYR   A 1 495 ? -20.629 -49.657 -13.080 1.00 29.64  ? 758  TYR   A CZ  1 
ATOM   3646 O  OH  . TYR   A 1 495 ? -20.204 -48.398 -12.684 1.00 27.70  ? 758  TYR   A OH  1 
ATOM   3647 N  N   . ALA   A 1 496 ? -23.426 -55.625 -16.234 1.00 20.94  ? 759  ALA   A N   1 
ATOM   3648 C  CA  . ALA   A 1 496 ? -23.363 -56.942 -16.911 1.00 19.22  ? 759  ALA   A CA  1 
ATOM   3649 C  C   . ALA   A 1 496 ? -23.655 -56.794 -18.403 1.00 20.98  ? 759  ALA   A C   1 
ATOM   3650 O  O   . ALA   A 1 496 ? -22.947 -57.422 -19.266 1.00 20.18  ? 759  ALA   A O   1 
ATOM   3651 C  CB  . ALA   A 1 496 ? -24.329 -57.893 -16.258 1.00 21.11  ? 759  ALA   A CB  1 
ATOM   3652 N  N   . GLN   A 1 497 ? -24.676 -56.040 -18.740 1.00 21.84  ? 760  GLN   A N   1 
ATOM   3653 C  CA  . GLN   A 1 497 ? -25.065 -55.822 -20.181 1.00 23.95  ? 760  GLN   A CA  1 
ATOM   3654 C  C   . GLN   A 1 497 ? -23.966 -54.997 -20.893 1.00 21.86  ? 760  GLN   A C   1 
ATOM   3655 O  O   . GLN   A 1 497 ? -23.631 -55.311 -22.099 1.00 23.13  ? 760  GLN   A O   1 
ATOM   3656 C  CB  . GLN   A 1 497 ? -26.496 -55.270 -20.273 1.00 27.39  ? 760  GLN   A CB  1 
ATOM   3657 C  CG  . GLN   A 1 497 ? -27.537 -56.317 -19.804 1.00 28.07  ? 760  GLN   A CG  1 
ATOM   3658 C  CD  . GLN   A 1 497 ? -29.006 -56.123 -20.166 1.00 29.35  ? 760  GLN   A CD  1 
ATOM   3659 O  OE1 . GLN   A 1 497 ? -29.797 -57.073 -20.109 1.00 29.44  ? 760  GLN   A OE1 1 
ATOM   3660 N  NE2 . GLN   A 1 497 ? -29.390 -54.906 -20.459 1.00 27.74  ? 760  GLN   A NE2 1 
ATOM   3661 N  N   . MET   A 1 498 ? -23.388 -54.011 -20.203 1.00 21.42  ? 761  MET   A N   1 
ATOM   3662 C  CA  . MET   A 1 498 ? -22.260 -53.232 -20.774 1.00 21.70  ? 761  MET   A CA  1 
ATOM   3663 C  C   . MET   A 1 498 ? -21.137 -54.214 -21.145 1.00 18.09  ? 761  MET   A C   1 
ATOM   3664 O  O   . MET   A 1 498 ? -20.681 -54.157 -22.280 1.00 22.08  ? 761  MET   A O   1 
ATOM   3665 C  CB  . MET   A 1 498 ? -21.761 -52.195 -19.766 1.00 24.71  ? 761  MET   A CB  1 
ATOM   3666 C  CG  . MET   A 1 498 ? -20.972 -51.074 -20.376 1.00 28.51  ? 761  MET   A CG  1 
ATOM   3667 S  SD  . MET   A 1 498 ? -19.240 -51.150 -19.916 1.00 39.53  ? 761  MET   A SD  1 
ATOM   3668 C  CE  . MET   A 1 498 ? -19.353 -51.327 -18.138 1.00 35.52  ? 761  MET   A CE  1 
ATOM   3669 N  N   . TRP   A 1 499 ? -20.800 -55.133 -20.245 1.00 22.18  ? 762  TRP   A N   1 
ATOM   3670 C  CA  . TRP   A 1 499 ? -19.754 -56.167 -20.479 1.00 21.78  ? 762  TRP   A CA  1 
ATOM   3671 C  C   . TRP   A 1 499 ? -20.075 -57.085 -21.686 1.00 25.63  ? 762  TRP   A C   1 
ATOM   3672 O  O   . TRP   A 1 499 ? -19.160 -57.342 -22.501 1.00 24.69  ? 762  TRP   A O   1 
ATOM   3673 C  CB  . TRP   A 1 499 ? -19.549 -56.956 -19.207 1.00 20.03  ? 762  TRP   A CB  1 
ATOM   3674 C  CG  . TRP   A 1 499 ? -18.899 -56.252 -18.061 1.00 20.11  ? 762  TRP   A CG  1 
ATOM   3675 C  CD1 . TRP   A 1 499 ? -18.395 -54.995 -18.026 1.00 20.56  ? 762  TRP   A CD1 1 
ATOM   3676 C  CD2 . TRP   A 1 499 ? -18.701 -56.784 -16.731 1.00 20.88  ? 762  TRP   A CD2 1 
ATOM   3677 N  NE1 . TRP   A 1 499 ? -17.959 -54.701 -16.769 1.00 21.02  ? 762  TRP   A NE1 1 
ATOM   3678 C  CE2 . TRP   A 1 499 ? -18.060 -55.802 -15.982 1.00 19.48  ? 762  TRP   A CE2 1 
ATOM   3679 C  CE3 . TRP   A 1 499 ? -19.005 -57.988 -16.099 1.00 23.48  ? 762  TRP   A CE3 1 
ATOM   3680 C  CZ2 . TRP   A 1 499 ? -17.687 -55.991 -14.650 1.00 22.95  ? 762  TRP   A CZ2 1 
ATOM   3681 C  CZ3 . TRP   A 1 499 ? -18.712 -58.161 -14.764 1.00 23.38  ? 762  TRP   A CZ3 1 
ATOM   3682 C  CH2 . TRP   A 1 499 ? -18.048 -57.179 -14.055 1.00 23.78  ? 762  TRP   A CH2 1 
ATOM   3683 N  N   A SER   A 1 500 ? -21.312 -57.590 -21.801 0.25 23.25  ? 763  SER   A N   1 
ATOM   3684 N  N   B SER   A 1 500 ? -21.321 -57.584 -21.781 0.25 25.27  ? 763  SER   A N   1 
ATOM   3685 C  CA  A SER   A 1 500 ? -21.712 -58.473 -22.926 0.25 22.73  ? 763  SER   A CA  1 
ATOM   3686 C  CA  B SER   A 1 500 ? -21.785 -58.449 -22.897 0.25 25.98  ? 763  SER   A CA  1 
ATOM   3687 C  C   A SER   A 1 500 ? -21.560 -57.727 -24.253 0.25 22.59  ? 763  SER   A C   1 
ATOM   3688 C  C   B SER   A 1 500 ? -21.567 -57.728 -24.231 0.25 24.28  ? 763  SER   A C   1 
ATOM   3689 O  O   A SER   A 1 500 ? -21.207 -58.373 -25.234 0.25 22.94  ? 763  SER   A O   1 
ATOM   3690 O  O   B SER   A 1 500 ? -21.176 -58.389 -25.188 0.25 24.27  ? 763  SER   A O   1 
ATOM   3691 C  CB  A SER   A 1 500 ? -23.098 -59.021 -22.745 0.25 22.00  ? 763  SER   A CB  1 
ATOM   3692 C  CB  B SER   A 1 500 ? -23.226 -58.896 -22.734 0.25 27.54  ? 763  SER   A CB  1 
ATOM   3693 O  OG  A SER   A 1 500 ? -23.239 -59.484 -21.418 0.25 19.63  ? 763  SER   A OG  1 
ATOM   3694 O  OG  B SER   A 1 500 ? -24.123 -57.796 -22.818 0.25 30.04  ? 763  SER   A OG  1 
ATOM   3695 N  N   . LEU   A 1 501 ? -21.753 -56.412 -24.265 1.00 25.22  ? 764  LEU   A N   1 
ATOM   3696 C  CA  . LEU   A 1 501 ? -21.692 -55.619 -25.524 1.00 25.85  ? 764  LEU   A CA  1 
ATOM   3697 C  C   . LEU   A 1 501 ? -20.272 -55.147 -25.873 1.00 27.57  ? 764  LEU   A C   1 
ATOM   3698 O  O   . LEU   A 1 501 ? -19.918 -55.113 -27.061 1.00 28.44  ? 764  LEU   A O   1 
ATOM   3699 C  CB  . LEU   A 1 501 ? -22.639 -54.440 -25.289 1.00 32.62  ? 764  LEU   A CB  1 
ATOM   3700 C  CG  . LEU   A 1 501 ? -23.536 -54.027 -26.430 1.00 44.90  ? 764  LEU   A CG  1 
ATOM   3701 C  CD1 . LEU   A 1 501 ? -23.863 -55.192 -27.373 1.00 50.65  ? 764  LEU   A CD1 1 
ATOM   3702 C  CD2 . LEU   A 1 501 ? -24.828 -53.465 -25.833 1.00 48.20  ? 764  LEU   A CD2 1 
ATOM   3703 N  N   . MET   A 1 502 ? -19.511 -54.679 -24.896 1.00 22.58  ? 765  MET   A N   1 
ATOM   3704 C  CA  . MET   A 1 502 ? -18.213 -54.025 -25.120 1.00 25.34  ? 765  MET   A CA  1 
ATOM   3705 C  C   . MET   A 1 502 ? -17.051 -54.998 -24.848 1.00 26.15  ? 765  MET   A C   1 
ATOM   3706 O  O   . MET   A 1 502 ? -16.066 -54.838 -25.519 1.00 21.65  ? 765  MET   A O   1 
ATOM   3707 C  CB  . MET   A 1 502 ? -18.097 -52.797 -24.223 1.00 25.90  ? 765  MET   A CB  1 
ATOM   3708 C  CG  . MET   A 1 502 ? -19.191 -51.724 -24.458 1.00 28.20  ? 765  MET   A CG  1 
ATOM   3709 S  SD  . MET   A 1 502 ? -19.102 -51.058 -26.143 1.00 34.65  ? 765  MET   A SD  1 
ATOM   3710 C  CE  . MET   A 1 502 ? -20.440 -51.890 -26.965 1.00 42.35  ? 765  MET   A CE  1 
ATOM   3711 N  N   . TYR   A 1 503 ? -17.164 -55.893 -23.863 1.00 20.72  ? 766  TYR   A N   1 
ATOM   3712 C  CA  . TYR   A 1 503 ? -16.031 -56.677 -23.303 1.00 22.52  ? 766  TYR   A CA  1 
ATOM   3713 C  C   . TYR   A 1 503 ? -16.303 -58.183 -23.394 1.00 22.35  ? 766  TYR   A C   1 
ATOM   3714 O  O   . TYR   A 1 503 ? -15.691 -58.946 -22.591 1.00 21.40  ? 766  TYR   A O   1 
ATOM   3715 C  CB  . TYR   A 1 503 ? -15.755 -56.238 -21.865 1.00 24.71  ? 766  TYR   A CB  1 
ATOM   3716 C  CG  . TYR   A 1 503 ? -15.536 -54.745 -21.659 1.00 23.35  ? 766  TYR   A CG  1 
ATOM   3717 C  CD1 . TYR   A 1 503 ? -14.543 -54.056 -22.336 1.00 25.81  ? 766  TYR   A CD1 1 
ATOM   3718 C  CD2 . TYR   A 1 503 ? -16.358 -53.994 -20.843 1.00 26.67  ? 766  TYR   A CD2 1 
ATOM   3719 C  CE1 . TYR   A 1 503 ? -14.372 -52.689 -22.178 1.00 22.42  ? 766  TYR   A CE1 1 
ATOM   3720 C  CE2 . TYR   A 1 503 ? -16.230 -52.616 -20.702 1.00 25.01  ? 766  TYR   A CE2 1 
ATOM   3721 C  CZ  . TYR   A 1 503 ? -15.204 -51.965 -21.345 1.00 25.18  ? 766  TYR   A CZ  1 
ATOM   3722 O  OH  . TYR   A 1 503 ? -15.035 -50.632 -21.136 1.00 23.98  ? 766  TYR   A OH  1 
ATOM   3723 N  N   . PHE   A 1 504 ? -17.148 -58.599 -24.355 1.00 21.51  ? 767  PHE   A N   1 
ATOM   3724 C  CA  . PHE   A 1 504 ? -17.549 -60.011 -24.599 1.00 24.46  ? 767  PHE   A CA  1 
ATOM   3725 C  C   . PHE   A 1 504 ? -16.316 -60.892 -24.882 1.00 23.75  ? 767  PHE   A C   1 
ATOM   3726 O  O   . PHE   A 1 504 ? -16.365 -62.130 -24.662 1.00 21.97  ? 767  PHE   A O   1 
ATOM   3727 C  CB  . PHE   A 1 504 ? -18.509 -60.107 -25.796 1.00 22.92  ? 767  PHE   A CB  1 
ATOM   3728 C  CG  . PHE   A 1 504 ? -18.006 -59.395 -27.012 1.00 21.80  ? 767  PHE   A CG  1 
ATOM   3729 C  CD1 . PHE   A 1 504 ? -17.182 -60.035 -27.905 1.00 23.84  ? 767  PHE   A CD1 1 
ATOM   3730 C  CD2 . PHE   A 1 504 ? -18.322 -58.067 -27.227 1.00 22.87  ? 767  PHE   A CD2 1 
ATOM   3731 C  CE1 . PHE   A 1 504 ? -16.693 -59.366 -28.996 1.00 22.22  ? 767  PHE   A CE1 1 
ATOM   3732 C  CE2 . PHE   A 1 504 ? -17.838 -57.411 -28.336 1.00 21.56  ? 767  PHE   A CE2 1 
ATOM   3733 C  CZ  . PHE   A 1 504 ? -17.019 -58.065 -29.195 1.00 23.25  ? 767  PHE   A CZ  1 
ATOM   3734 N  N   . HIS   A 1 505 ? -15.236 -60.248 -25.351 1.00 23.69  ? 768  HIS   A N   1 
ATOM   3735 C  CA  . HIS   A 1 505 ? -13.946 -60.873 -25.758 1.00 20.68  ? 768  HIS   A CA  1 
ATOM   3736 C  C   . HIS   A 1 505 ? -13.057 -61.218 -24.559 1.00 20.80  ? 768  HIS   A C   1 
ATOM   3737 O  O   . HIS   A 1 505 ? -12.025 -61.921 -24.744 1.00 22.20  ? 768  HIS   A O   1 
ATOM   3738 C  CB  . HIS   A 1 505 ? -13.222 -60.005 -26.770 1.00 22.57  ? 768  HIS   A CB  1 
ATOM   3739 C  CG  . HIS   A 1 505 ? -13.049 -58.598 -26.325 1.00 21.69  ? 768  HIS   A CG  1 
ATOM   3740 N  ND1 . HIS   A 1 505 ? -12.012 -58.211 -25.548 1.00 21.79  ? 768  HIS   A ND1 1 
ATOM   3741 C  CD2 . HIS   A 1 505 ? -13.867 -57.522 -26.496 1.00 24.96  ? 768  HIS   A CD2 1 
ATOM   3742 C  CE1 . HIS   A 1 505 ? -12.149 -56.932 -25.289 1.00 23.87  ? 768  HIS   A CE1 1 
ATOM   3743 N  NE2 . HIS   A 1 505 ? -13.293 -56.464 -25.857 1.00 22.84  ? 768  HIS   A NE2 1 
ATOM   3744 N  N   . ARG   A 1 506 ? -13.467 -60.854 -23.348 1.00 19.80  ? 769  ARG   A N   1 
ATOM   3745 C  CA  . ARG   A 1 506 ? -12.707 -61.158 -22.100 1.00 19.40  ? 769  ARG   A CA  1 
ATOM   3746 C  C   . ARG   A 1 506 ? -13.434 -62.334 -21.445 1.00 22.03  ? 769  ARG   A C   1 
ATOM   3747 O  O   . ARG   A 1 506 ? -14.652 -62.145 -21.140 1.00 22.49  ? 769  ARG   A O   1 
ATOM   3748 C  CB  . ARG   A 1 506 ? -12.725 -59.950 -21.152 1.00 18.20  ? 769  ARG   A CB  1 
ATOM   3749 C  CG  . ARG   A 1 506 ? -12.238 -58.656 -21.796 1.00 21.07  ? 769  ARG   A CG  1 
ATOM   3750 C  CD  . ARG   A 1 506 ? -10.857 -58.797 -22.480 1.00 20.63  ? 769  ARG   A CD  1 
ATOM   3751 N  NE  . ARG   A 1 506 ? -9.905  -59.316 -21.511 1.00 20.46  ? 769  ARG   A NE  1 
ATOM   3752 C  CZ  . ARG   A 1 506 ? -9.374  -58.643 -20.496 1.00 23.45  ? 769  ARG   A CZ  1 
ATOM   3753 N  NH1 . ARG   A 1 506 ? -8.627  -59.277 -19.595 1.00 23.36  ? 769  ARG   A NH1 1 
ATOM   3754 N  NH2 . ARG   A 1 506 ? -9.524  -57.338 -20.382 1.00 21.65  ? 769  ARG   A NH2 1 
ATOM   3755 N  N   . ARG   A 1 507 ? -12.792 -63.510 -21.339 1.00 20.79  ? 770  ARG   A N   1 
ATOM   3756 C  CA  . ARG   A 1 507 ? -13.439 -64.732 -20.852 1.00 22.20  ? 770  ARG   A CA  1 
ATOM   3757 C  C   . ARG   A 1 507 ? -14.156 -64.469 -19.520 1.00 20.94  ? 770  ARG   A C   1 
ATOM   3758 O  O   . ARG   A 1 507 ? -15.321 -64.847 -19.417 1.00 22.80  ? 770  ARG   A O   1 
ATOM   3759 C  CB  . ARG   A 1 507 ? -12.450 -65.898 -20.689 1.00 25.32  ? 770  ARG   A CB  1 
ATOM   3760 C  CG  . ARG   A 1 507 ? -11.845 -66.393 -21.996 1.00 26.86  ? 770  ARG   A CG  1 
ATOM   3761 C  CD  . ARG   A 1 507 ? -10.582 -67.237 -21.800 1.00 27.39  ? 770  ARG   A CD  1 
ATOM   3762 N  NE  . ARG   A 1 507 ? -10.234 -67.761 -23.127 1.00 27.88  ? 770  ARG   A NE  1 
ATOM   3763 C  CZ  . ARG   A 1 507 ? -9.662  -67.067 -24.076 1.00 28.18  ? 770  ARG   A CZ  1 
ATOM   3764 N  NH1 . ARG   A 1 507 ? -9.340  -65.789 -23.896 1.00 26.18  ? 770  ARG   A NH1 1 
ATOM   3765 N  NH2 . ARG   A 1 507 ? -9.424  -67.631 -25.241 1.00 27.11  ? 770  ARG   A NH2 1 
ATOM   3766 N  N   . ASP   A 1 508 ? -13.501 -63.862 -18.537 1.00 20.76  ? 771  ASP   A N   1 
ATOM   3767 C  CA  . ASP   A 1 508 ? -14.059 -63.677 -17.186 1.00 23.56  ? 771  ASP   A CA  1 
ATOM   3768 C  C   . ASP   A 1 508 ? -15.307 -62.776 -17.224 1.00 24.48  ? 771  ASP   A C   1 
ATOM   3769 O  O   . ASP   A 1 508 ? -16.228 -62.999 -16.424 1.00 22.31  ? 771  ASP   A O   1 
ATOM   3770 C  CB  . ASP   A 1 508 ? -13.041 -63.081 -16.225 1.00 22.58  ? 771  ASP   A CB  1 
ATOM   3771 C  CG  . ASP   A 1 508 ? -11.829 -63.967 -15.988 1.00 25.26  ? 771  ASP   A CG  1 
ATOM   3772 O  OD1 . ASP   A 1 508 ? -11.860 -65.172 -16.398 1.00 22.60  ? 771  ASP   A OD1 1 
ATOM   3773 O  OD2 . ASP   A 1 508 ? -10.853 -63.430 -15.422 1.00 21.54  ? 771  ASP   A OD2 1 
ATOM   3774 N  N   . LEU   A 1 509 ? -15.312 -61.748 -18.061 1.00 23.32  ? 772  LEU   A N   1 
ATOM   3775 C  CA  . LEU   A 1 509 ? -16.423 -60.781 -18.039 1.00 21.90  ? 772  LEU   A CA  1 
ATOM   3776 C  C   . LEU   A 1 509 ? -17.621 -61.370 -18.780 1.00 23.02  ? 772  LEU   A C   1 
ATOM   3777 O  O   . LEU   A 1 509 ? -18.717 -61.095 -18.372 1.00 22.22  ? 772  LEU   A O   1 
ATOM   3778 C  CB  . LEU   A 1 509 ? -15.989 -59.447 -18.620 1.00 20.93  ? 772  LEU   A CB  1 
ATOM   3779 C  CG  . LEU   A 1 509 ? -14.830 -58.744 -17.898 1.00 20.80  ? 772  LEU   A CG  1 
ATOM   3780 C  CD1 . LEU   A 1 509 ? -14.611 -57.350 -18.507 1.00 22.33  ? 772  LEU   A CD1 1 
ATOM   3781 C  CD2 . LEU   A 1 509 ? -15.145 -58.641 -16.404 1.00 21.82  ? 772  LEU   A CD2 1 
ATOM   3782 N  N   . ARG   A 1 510 ? -17.432 -62.176 -19.812 1.00 22.83  ? 773  ARG   A N   1 
ATOM   3783 C  CA  . ARG   A 1 510 ? -18.611 -62.768 -20.505 1.00 25.16  ? 773  ARG   A CA  1 
ATOM   3784 C  C   . ARG   A 1 510 ? -19.272 -63.735 -19.523 1.00 27.09  ? 773  ARG   A C   1 
ATOM   3785 O  O   . ARG   A 1 510 ? -20.496 -63.780 -19.467 1.00 26.24  ? 773  ARG   A O   1 
ATOM   3786 C  CB  . ARG   A 1 510 ? -18.263 -63.539 -21.765 1.00 22.85  ? 773  ARG   A CB  1 
ATOM   3787 C  CG  . ARG   A 1 510 ? -19.461 -63.817 -22.680 1.00 25.05  ? 773  ARG   A CG  1 
ATOM   3788 C  CD  . ARG   A 1 510 ? -19.217 -64.711 -23.869 1.00 25.41  ? 773  ARG   A CD  1 
ATOM   3789 N  NE  . ARG   A 1 510 ? -18.291 -64.152 -24.824 1.00 24.70  ? 773  ARG   A NE  1 
ATOM   3790 C  CZ  . ARG   A 1 510 ? -18.149 -64.577 -26.060 1.00 24.03  ? 773  ARG   A CZ  1 
ATOM   3791 N  NH1 . ARG   A 1 510 ? -18.927 -65.544 -26.534 1.00 27.97  ? 773  ARG   A NH1 1 
ATOM   3792 N  NH2 . ARG   A 1 510 ? -17.260 -64.015 -26.844 1.00 24.98  ? 773  ARG   A NH2 1 
ATOM   3793 N  N   . LEU   A 1 511 ? -18.467 -64.491 -18.769 1.00 24.77  ? 774  LEU   A N   1 
ATOM   3794 C  CA  . LEU   A 1 511 ? -18.967 -65.462 -17.788 1.00 25.56  ? 774  LEU   A CA  1 
ATOM   3795 C  C   . LEU   A 1 511 ? -19.656 -64.692 -16.657 1.00 23.39  ? 774  LEU   A C   1 
ATOM   3796 O  O   . LEU   A 1 511 ? -20.782 -65.075 -16.279 1.00 21.59  ? 774  LEU   A O   1 
ATOM   3797 C  CB  . LEU   A 1 511 ? -17.838 -66.357 -17.263 1.00 26.31  ? 774  LEU   A CB  1 
ATOM   3798 C  CG  . LEU   A 1 511 ? -18.270 -67.656 -16.587 1.00 26.16  ? 774  LEU   A CG  1 
ATOM   3799 C  CD1 . LEU   A 1 511 ? -17.093 -68.592 -16.486 1.00 28.78  ? 774  LEU   A CD1 1 
ATOM   3800 C  CD2 . LEU   A 1 511 ? -18.819 -67.444 -15.192 1.00 27.30  ? 774  LEU   A CD2 1 
ATOM   3801 N  N   . ALA   A 1 512 ? -19.046 -63.657 -16.117 1.00 22.97  ? 775  ALA   A N   1 
ATOM   3802 C  CA  . ALA   A 1 512 ? -19.650 -62.934 -14.974 1.00 22.18  ? 775  ALA   A CA  1 
ATOM   3803 C  C   . ALA   A 1 512 ? -20.934 -62.197 -15.450 1.00 21.89  ? 775  ALA   A C   1 
ATOM   3804 O  O   . ALA   A 1 512 ? -21.924 -62.126 -14.693 1.00 21.04  ? 775  ALA   A O   1 
ATOM   3805 C  CB  . ALA   A 1 512 ? -18.676 -61.982 -14.329 1.00 20.24  ? 775  ALA   A CB  1 
ATOM   3806 N  N   . ALA   A 1 513 ? -20.934 -61.657 -16.648 1.00 21.60  ? 776  ALA   A N   1 
ATOM   3807 C  CA  . ALA   A 1 513 ? -22.122 -60.986 -17.242 1.00 23.58  ? 776  ALA   A CA  1 
ATOM   3808 C  C   . ALA   A 1 513 ? -23.289 -61.985 -17.336 1.00 25.06  ? 776  ALA   A C   1 
ATOM   3809 O  O   . ALA   A 1 513 ? -24.403 -61.643 -16.905 1.00 24.51  ? 776  ALA   A O   1 
ATOM   3810 C  CB  . ALA   A 1 513 ? -21.852 -60.396 -18.608 1.00 23.11  ? 776  ALA   A CB  1 
ATOM   3811 N  N   . ASN   A 1 514 ? -23.017 -63.172 -17.839 1.00 24.08  ? 777  ASN   A N   1 
ATOM   3812 C  CA  . ASN   A 1 514 ? -24.040 -64.251 -17.943 1.00 24.91  ? 777  ASN   A CA  1 
ATOM   3813 C  C   . ASN   A 1 514 ? -24.538 -64.599 -16.542 1.00 23.51  ? 777  ASN   A C   1 
ATOM   3814 O  O   . ASN   A 1 514 ? -25.779 -64.713 -16.362 1.00 24.25  ? 777  ASN   A O   1 
ATOM   3815 C  CB  . ASN   A 1 514 ? -23.478 -65.440 -18.677 1.00 25.63  ? 777  ASN   A CB  1 
ATOM   3816 C  CG  . ASN   A 1 514 ? -23.479 -65.167 -20.174 1.00 30.91  ? 777  ASN   A CG  1 
ATOM   3817 O  OD1 . ASN   A 1 514 ? -24.320 -64.450 -20.687 1.00 31.37  ? 777  ASN   A OD1 1 
ATOM   3818 N  ND2 . ASN   A 1 514 ? -22.541 -65.746 -20.887 1.00 31.06  ? 777  ASN   A ND2 1 
ATOM   3819 N  N   . ALA   A 1 515 ? -23.638 -64.710 -15.562 1.00 24.55  ? 778  ALA   A N   1 
ATOM   3820 C  CA  . ALA   A 1 515 ? -24.038 -65.043 -14.186 1.00 22.20  ? 778  ALA   A CA  1 
ATOM   3821 C  C   . ALA   A 1 515 ? -24.956 -63.936 -13.630 1.00 23.95  ? 778  ALA   A C   1 
ATOM   3822 O  O   . ALA   A 1 515 ? -25.984 -64.251 -13.039 1.00 23.50  ? 778  ALA   A O   1 
ATOM   3823 C  CB  . ALA   A 1 515 ? -22.847 -65.304 -13.302 1.00 22.88  ? 778  ALA   A CB  1 
ATOM   3824 N  N   . ILE   A 1 516 ? -24.568 -62.663 -13.703 1.00 23.40  ? 779  ILE   A N   1 
ATOM   3825 C  CA  . ILE   A 1 516 ? -25.370 -61.554 -13.153 1.00 23.23  ? 779  ILE   A CA  1 
ATOM   3826 C  C   . ILE   A 1 516 ? -26.733 -61.522 -13.874 1.00 25.11  ? 779  ILE   A C   1 
ATOM   3827 O  O   . ILE   A 1 516 ? -27.739 -61.447 -13.192 1.00 23.21  ? 779  ILE   A O   1 
ATOM   3828 C  CB  . ILE   A 1 516 ? -24.640 -60.201 -13.292 1.00 22.34  ? 779  ILE   A CB  1 
ATOM   3829 C  CG1 . ILE   A 1 516 ? -23.374 -60.153 -12.453 1.00 22.74  ? 779  ILE   A CG1 1 
ATOM   3830 C  CG2 . ILE   A 1 516 ? -25.585 -59.059 -12.965 1.00 21.15  ? 779  ILE   A CG2 1 
ATOM   3831 C  CD1 . ILE   A 1 516 ? -22.391 -59.071 -12.904 1.00 21.21  ? 779  ILE   A CD1 1 
ATOM   3832 N  N   . CYS   A 1 517 ? -26.796 -61.663 -15.195 1.00 23.32  ? 780  CYS   A N   1 
ATOM   3833 C  CA  . CYS   A 1 517 ? -28.084 -61.638 -15.925 1.00 24.70  ? 780  CYS   A CA  1 
ATOM   3834 C  C   . CYS   A 1 517 ? -28.912 -62.856 -15.521 1.00 28.67  ? 780  CYS   A C   1 
ATOM   3835 O  O   . CYS   A 1 517 ? -30.140 -62.729 -15.594 1.00 27.14  ? 780  CYS   A O   1 
ATOM   3836 C  CB  . CYS   A 1 517 ? -27.902 -61.519 -17.440 1.00 25.95  ? 780  CYS   A CB  1 
ATOM   3837 S  SG  . CYS   A 1 517 ? -27.230 -59.882 -17.843 1.00 30.75  ? 780  CYS   A SG  1 
ATOM   3838 N  N   . SER   A 1 518 ? -28.298 -63.949 -15.060 1.00 24.68  ? 781  SER   A N   1 
ATOM   3839 C  CA  . SER   A 1 518 ? -29.085 -65.139 -14.659 1.00 24.97  ? 781  SER   A CA  1 
ATOM   3840 C  C   . SER   A 1 518 ? -29.601 -64.919 -13.237 1.00 26.41  ? 781  SER   A C   1 
ATOM   3841 O  O   . SER   A 1 518 ? -30.579 -65.586 -12.877 1.00 26.61  ? 781  SER   A O   1 
ATOM   3842 C  CB  . SER   A 1 518 ? -28.301 -66.424 -14.741 1.00 26.94  ? 781  SER   A CB  1 
ATOM   3843 O  OG  . SER   A 1 518 ? -27.775 -66.642 -16.049 1.00 28.99  ? 781  SER   A OG  1 
ATOM   3844 N  N   . ALA   A 1 519 ? -28.940 -64.053 -12.451 1.00 25.14  ? 782  ALA   A N   1 
ATOM   3845 C  CA  . ALA   A 1 519 ? -29.200 -63.893 -10.999 1.00 24.13  ? 782  ALA   A CA  1 
ATOM   3846 C  C   . ALA   A 1 519 ? -30.244 -62.800 -10.769 1.00 24.84  ? 782  ALA   A C   1 
ATOM   3847 O  O   . ALA   A 1 519 ? -30.754 -62.735 -9.662  1.00 26.99  ? 782  ALA   A O   1 
ATOM   3848 C  CB  . ALA   A 1 519 ? -27.941 -63.640 -10.194 1.00 24.79  ? 782  ALA   A CB  1 
ATOM   3849 N  N   . VAL   A 1 520 ? -30.420 -61.905 -11.726 1.00 25.21  ? 783  VAL   A N   1 
ATOM   3850 C  CA  . VAL   A 1 520 ? -31.347 -60.762 -11.645 1.00 26.82  ? 783  VAL   A CA  1 
ATOM   3851 C  C   . VAL   A 1 520 ? -32.610 -61.114 -12.447 1.00 28.48  ? 783  VAL   A C   1 
ATOM   3852 O  O   . VAL   A 1 520 ? -32.533 -61.625 -13.574 1.00 25.12  ? 783  VAL   A O   1 
ATOM   3853 C  CB  . VAL   A 1 520 ? -30.671 -59.474 -12.160 1.00 29.16  ? 783  VAL   A CB  1 
ATOM   3854 C  CG1 . VAL   A 1 520 ? -31.649 -58.301 -12.185 1.00 26.84  ? 783  VAL   A CG1 1 
ATOM   3855 C  CG2 . VAL   A 1 520 ? -29.424 -59.125 -11.332 1.00 26.20  ? 783  VAL   A CG2 1 
ATOM   3856 N  N   . PRO   A 1 521 ? -33.827 -60.844 -11.910 1.00 27.36  ? 784  PRO   A N   1 
ATOM   3857 C  CA  . PRO   A 1 521 ? -35.051 -61.215 -12.628 1.00 28.40  ? 784  PRO   A CA  1 
ATOM   3858 C  C   . PRO   A 1 521 ? -34.990 -60.717 -14.083 1.00 26.17  ? 784  PRO   A C   1 
ATOM   3859 O  O   . PRO   A 1 521 ? -34.611 -59.570 -14.338 1.00 27.55  ? 784  PRO   A O   1 
ATOM   3860 C  CB  . PRO   A 1 521 ? -36.148 -60.605 -11.717 1.00 25.19  ? 784  PRO   A CB  1 
ATOM   3861 C  CG  . PRO   A 1 521 ? -35.571 -60.742 -10.298 1.00 25.56  ? 784  PRO   A CG  1 
ATOM   3862 C  CD  . PRO   A 1 521 ? -34.094 -60.410 -10.521 1.00 26.32  ? 784  PRO   A CD  1 
ATOM   3863 N  N   A SER   A 1 522 ? -35.366 -61.589 -15.017 0.25 28.51  ? 785  SER   A N   1 
ATOM   3864 N  N   B SER   A 1 522 ? -35.406 -61.585 -15.006 0.25 27.82  ? 785  SER   A N   1 
ATOM   3865 C  CA  A SER   A 1 522 ? -35.271 -61.376 -16.483 0.25 31.49  ? 785  SER   A CA  1 
ATOM   3866 C  CA  B SER   A 1 522 ? -35.305 -61.411 -16.476 0.25 30.26  ? 785  SER   A CA  1 
ATOM   3867 C  C   A SER   A 1 522 ? -35.864 -60.022 -16.888 0.25 32.57  ? 785  SER   A C   1 
ATOM   3868 C  C   B SER   A 1 522 ? -35.901 -60.071 -16.923 0.25 31.76  ? 785  SER   A C   1 
ATOM   3869 O  O   A SER   A 1 522 ? -35.245 -59.359 -17.734 0.25 30.76  ? 785  SER   A O   1 
ATOM   3870 O  O   B SER   A 1 522 ? -35.313 -59.461 -17.827 0.25 29.88  ? 785  SER   A O   1 
ATOM   3871 C  CB  A SER   A 1 522 ? -35.954 -62.486 -17.223 0.25 33.95  ? 785  SER   A CB  1 
ATOM   3872 C  CB  B SER   A 1 522 ? -35.961 -62.566 -17.189 0.25 31.78  ? 785  SER   A CB  1 
ATOM   3873 O  OG  A SER   A 1 522 ? -37.346 -62.438 -16.973 0.25 38.15  ? 785  SER   A OG  1 
ATOM   3874 O  OG  B SER   A 1 522 ? -35.829 -63.760 -16.431 0.25 33.69  ? 785  SER   A OG  1 
ATOM   3875 N  N   . HIS   A 1 523 ? -37.010 -59.621 -16.313 1.00 31.86  ? 786  HIS   A N   1 
ATOM   3876 C  CA  . HIS   A 1 523 ? -37.756 -58.399 -16.773 1.00 29.19  ? 786  HIS   A CA  1 
ATOM   3877 C  C   . HIS   A 1 523 ? -37.372 -57.124 -16.037 1.00 31.23  ? 786  HIS   A C   1 
ATOM   3878 O  O   . HIS   A 1 523 ? -37.841 -56.018 -16.459 1.00 30.73  ? 786  HIS   A O   1 
ATOM   3879 C  CB  . HIS   A 1 523 ? -39.285 -58.638 -16.769 1.00 34.98  ? 786  HIS   A CB  1 
ATOM   3880 C  CG  . HIS   A 1 523 ? -39.693 -59.739 -17.687 1.00 33.86  ? 786  HIS   A CG  1 
ATOM   3881 N  ND1 . HIS   A 1 523 ? -39.826 -59.535 -19.053 1.00 37.45  ? 786  HIS   A ND1 1 
ATOM   3882 C  CD2 . HIS   A 1 523 ? -39.945 -61.050 -17.466 1.00 40.09  ? 786  HIS   A CD2 1 
ATOM   3883 C  CE1 . HIS   A 1 523 ? -40.163 -60.680 -19.626 1.00 40.35  ? 786  HIS   A CE1 1 
ATOM   3884 N  NE2 . HIS   A 1 523 ? -40.261 -61.626 -18.677 1.00 35.68  ? 786  HIS   A NE2 1 
ATOM   3885 N  N   . TRP   A 1 524 ? -36.537 -57.206 -14.993 1.00 28.15  ? 787  TRP   A N   1 
ATOM   3886 C  CA  . TRP   A 1 524 ? -36.122 -55.986 -14.276 1.00 28.00  ? 787  TRP   A CA  1 
ATOM   3887 C  C   . TRP   A 1 524 ? -35.230 -55.162 -15.197 1.00 28.76  ? 787  TRP   A C   1 
ATOM   3888 O  O   . TRP   A 1 524 ? -34.384 -55.734 -15.879 1.00 28.45  ? 787  TRP   A O   1 
ATOM   3889 C  CB  . TRP   A 1 524 ? -35.475 -56.354 -12.924 1.00 30.45  ? 787  TRP   A CB  1 
ATOM   3890 C  CG  . TRP   A 1 524 ? -36.473 -56.810 -11.888 1.00 30.02  ? 787  TRP   A CG  1 
ATOM   3891 C  CD1 . TRP   A 1 524 ? -37.802 -57.120 -12.063 1.00 31.52  ? 787  TRP   A CD1 1 
ATOM   3892 C  CD2 . TRP   A 1 524 ? -36.193 -57.073 -10.504 1.00 30.05  ? 787  TRP   A CD2 1 
ATOM   3893 N  NE1 . TRP   A 1 524 ? -38.352 -57.569 -10.881 1.00 33.18  ? 787  TRP   A NE1 1 
ATOM   3894 C  CE2 . TRP   A 1 524 ? -37.405 -57.495 -9.894  1.00 29.12  ? 787  TRP   A CE2 1 
ATOM   3895 C  CE3 . TRP   A 1 524 ? -35.026 -57.012 -9.737  1.00 31.44  ? 787  TRP   A CE3 1 
ATOM   3896 C  CZ2 . TRP   A 1 524 ? -37.471 -57.837 -8.541  1.00 30.88  ? 787  TRP   A CZ2 1 
ATOM   3897 C  CZ3 . TRP   A 1 524 ? -35.110 -57.339 -8.391  1.00 32.58  ? 787  TRP   A CZ3 1 
ATOM   3898 C  CH2 . TRP   A 1 524 ? -36.309 -57.720 -7.801  1.00 27.75  ? 787  TRP   A CH2 1 
ATOM   3899 N  N   . VAL   A 1 525 ? -35.460 -53.862 -15.199 1.00 28.12  ? 788  VAL   A N   1 
ATOM   3900 C  CA  . VAL   A 1 525 ? -34.886 -52.908 -16.165 1.00 32.09  ? 788  VAL   A CA  1 
ATOM   3901 C  C   . VAL   A 1 525 ? -33.564 -52.382 -15.589 1.00 32.09  ? 788  VAL   A C   1 
ATOM   3902 O  O   . VAL   A 1 525 ? -33.480 -51.866 -14.475 1.00 31.61  ? 788  VAL   A O   1 
ATOM   3903 C  CB  . VAL   A 1 525 ? -35.897 -51.769 -16.413 1.00 35.89  ? 788  VAL   A CB  1 
ATOM   3904 C  CG1 . VAL   A 1 525 ? -35.326 -50.716 -17.362 1.00 37.30  ? 788  VAL   A CG1 1 
ATOM   3905 C  CG2 . VAL   A 1 525 ? -37.267 -52.277 -16.873 1.00 38.61  ? 788  VAL   A CG2 1 
ATOM   3906 N  N   . PRO   A 1 526 ? -32.427 -52.523 -16.292 1.00 33.76  ? 789  PRO   A N   1 
ATOM   3907 C  CA  . PRO   A 1 526 ? -31.182 -51.945 -15.799 1.00 32.87  ? 789  PRO   A CA  1 
ATOM   3908 C  C   . PRO   A 1 526 ? -31.310 -50.431 -15.510 1.00 34.01  ? 789  PRO   A C   1 
ATOM   3909 O  O   . PRO   A 1 526 ? -32.002 -49.768 -16.224 1.00 32.86  ? 789  PRO   A O   1 
ATOM   3910 C  CB  . PRO   A 1 526 ? -30.199 -52.253 -16.937 1.00 32.30  ? 789  PRO   A CB  1 
ATOM   3911 C  CG  . PRO   A 1 526 ? -30.791 -53.422 -17.679 1.00 32.97  ? 789  PRO   A CG  1 
ATOM   3912 C  CD  . PRO   A 1 526 ? -32.282 -53.221 -17.573 1.00 34.49  ? 789  PRO   A CD  1 
ATOM   3913 N  N   . THR   A 1 527 ? -30.634 -49.945 -14.463 0.25 34.64  ? 790  THR   A N   1 
ATOM   3914 C  CA  . THR   A 1 527 ? -30.734 -48.510 -14.080 0.25 36.41  ? 790  THR   A CA  1 
ATOM   3915 C  C   . THR   A 1 527 ? -29.358 -47.906 -13.800 0.25 36.27  ? 790  THR   A C   1 
ATOM   3916 O  O   . THR   A 1 527 ? -28.419 -48.674 -13.532 0.25 34.55  ? 790  THR   A O   1 
ATOM   3917 C  CB  . THR   A 1 527 ? -31.585 -48.307 -12.822 0.25 39.18  ? 790  THR   A CB  1 
ATOM   3918 O  OG1 . THR   A 1 527 ? -31.057 -49.129 -11.780 0.25 40.53  ? 790  THR   A OG1 1 
ATOM   3919 C  CG2 . THR   A 1 527 ? -33.045 -48.628 -13.042 0.25 40.20  ? 790  THR   A CG2 1 
ATOM   3920 N  N   . SER   A 1 528 ? -29.264 -46.576 -13.846 0.25 36.46  ? 791  SER   A N   1 
ATOM   3921 C  CA  . SER   A 1 528 ? -27.990 -45.867 -13.561 0.25 39.09  ? 791  SER   A CA  1 
ATOM   3922 C  C   . SER   A 1 528 ? -28.303 -44.565 -12.819 0.25 39.61  ? 791  SER   A C   1 
ATOM   3923 O  O   . SER   A 1 528 ? -28.394 -43.517 -13.481 0.25 40.87  ? 791  SER   A O   1 
ATOM   3924 C  CB  . SER   A 1 528 ? -27.225 -45.589 -14.822 0.25 38.02  ? 791  SER   A CB  1 
ATOM   3925 O  OG  . SER   A 1 528 ? -26.006 -44.925 -14.532 0.25 40.91  ? 791  SER   A OG  1 
ATOM   3926 N  N   . ARG   A 1 529 ? -28.465 -44.638 -11.497 0.25 38.48  ? 792  ARG   A N   1 
ATOM   3927 C  CA  . ARG   A 1 529 ? -28.810 -43.433 -10.700 0.25 39.33  ? 792  ARG   A CA  1 
ATOM   3928 C  C   . ARG   A 1 529 ? -27.781 -42.332 -10.978 0.25 39.73  ? 792  ARG   A C   1 
ATOM   3929 O  O   . ARG   A 1 529 ? -28.193 -41.290 -11.521 0.25 38.46  ? 792  ARG   A O   1 
ATOM   3930 C  CB  . ARG   A 1 529 ? -28.866 -43.784 -9.211  0.25 39.22  ? 792  ARG   A CB  1 
ATOM   3931 C  CG  . ARG   A 1 529 ? -29.237 -42.606 -8.323  0.25 39.86  ? 792  ARG   A CG  1 
ATOM   3932 C  CD  . ARG   A 1 529 ? -28.995 -42.888 -6.855  0.25 38.89  ? 792  ARG   A CD  1 
ATOM   3933 N  NE  . ARG   A 1 529 ? -29.865 -43.917 -6.311  0.25 38.31  ? 792  ARG   A NE  1 
ATOM   3934 C  CZ  . ARG   A 1 529 ? -29.879 -44.268 -5.032  0.25 36.70  ? 792  ARG   A CZ  1 
ATOM   3935 N  NH1 . ARG   A 1 529 ? -29.069 -43.665 -4.180  0.25 36.40  ? 792  ARG   A NH1 1 
ATOM   3936 N  NH2 . ARG   A 1 529 ? -30.699 -45.212 -4.610  0.25 35.47  ? 792  ARG   A NH2 1 
ATOM   3937 N  N   . HIS   A 1 535 ? -21.803 -37.677 -25.886 0.25 69.58  ? 798  HIS   A N   1 
ATOM   3938 C  CA  . HIS   A 1 535 ? -20.376 -38.103 -25.874 0.25 69.29  ? 798  HIS   A CA  1 
ATOM   3939 C  C   . HIS   A 1 535 ? -20.272 -39.606 -26.166 0.25 69.96  ? 798  HIS   A C   1 
ATOM   3940 O  O   . HIS   A 1 535 ? -19.455 -39.979 -27.032 0.25 72.59  ? 798  HIS   A O   1 
ATOM   3941 C  CB  . HIS   A 1 535 ? -19.697 -37.724 -24.549 0.25 70.44  ? 798  HIS   A CB  1 
ATOM   3942 C  CG  . HIS   A 1 535 ? -18.406 -38.438 -24.330 0.25 71.31  ? 798  HIS   A CG  1 
ATOM   3943 N  ND1 . HIS   A 1 535 ? -17.420 -38.492 -25.298 0.25 68.88  ? 798  HIS   A ND1 1 
ATOM   3944 C  CD2 . HIS   A 1 535 ? -17.943 -39.141 -23.275 0.25 71.43  ? 798  HIS   A CD2 1 
ATOM   3945 C  CE1 . HIS   A 1 535 ? -16.404 -39.195 -24.846 0.25 69.53  ? 798  HIS   A CE1 1 
ATOM   3946 N  NE2 . HIS   A 1 535 ? -16.697 -39.602 -23.606 0.25 71.54  ? 798  HIS   A NE2 1 
ATOM   3947 N  N   . ALA   A 1 536 ? -21.110 -40.421 -25.514 0.25 70.03  ? 799  ALA   A N   1 
ATOM   3948 C  CA  . ALA   A 1 536 ? -21.040 -41.893 -25.685 0.25 67.35  ? 799  ALA   A CA  1 
ATOM   3949 C  C   . ALA   A 1 536 ? -22.444 -42.471 -25.895 0.25 64.79  ? 799  ALA   A C   1 
ATOM   3950 O  O   . ALA   A 1 536 ? -23.422 -41.713 -25.737 0.25 65.91  ? 799  ALA   A O   1 
ATOM   3951 C  CB  . ALA   A 1 536 ? -20.362 -42.511 -24.489 0.25 66.44  ? 799  ALA   A CB  1 
ATOM   3952 N  N   . THR   A 1 537 ? -22.536 -43.758 -26.244 0.25 60.35  ? 800  THR   A N   1 
ATOM   3953 C  CA  . THR   A 1 537 ? -23.858 -44.377 -26.537 0.25 57.14  ? 800  THR   A CA  1 
ATOM   3954 C  C   . THR   A 1 537 ? -24.099 -45.558 -25.591 0.25 54.10  ? 800  THR   A C   1 
ATOM   3955 O  O   . THR   A 1 537 ? -23.215 -46.431 -25.513 0.25 55.37  ? 800  THR   A O   1 
ATOM   3956 C  CB  . THR   A 1 537 ? -23.958 -44.783 -28.012 0.25 57.87  ? 800  THR   A CB  1 
ATOM   3957 O  OG1 . THR   A 1 537 ? -23.044 -45.856 -28.237 0.25 58.87  ? 800  THR   A OG1 1 
ATOM   3958 C  CG2 . THR   A 1 537 ? -23.650 -43.644 -28.958 0.25 57.45  ? 800  THR   A CG2 1 
ATOM   3959 N  N   . HIS   A 1 538 ? -25.251 -45.583 -24.913 0.25 49.47  ? 801  HIS   A N   1 
ATOM   3960 C  CA  . HIS   A 1 538 ? -25.559 -46.652 -23.926 0.25 46.04  ? 801  HIS   A CA  1 
ATOM   3961 C  C   . HIS   A 1 538 ? -26.546 -47.664 -24.517 0.25 41.52  ? 801  HIS   A C   1 
ATOM   3962 O  O   . HIS   A 1 538 ? -27.734 -47.608 -24.147 0.25 40.10  ? 801  HIS   A O   1 
ATOM   3963 C  CB  . HIS   A 1 538 ? -26.119 -46.022 -22.649 0.25 47.78  ? 801  HIS   A CB  1 
ATOM   3964 C  CG  . HIS   A 1 538 ? -25.149 -45.159 -21.918 0.25 49.07  ? 801  HIS   A CG  1 
ATOM   3965 N  ND1 . HIS   A 1 538 ? -24.591 -45.537 -20.713 0.25 50.00  ? 801  HIS   A ND1 1 
ATOM   3966 C  CD2 . HIS   A 1 538 ? -24.639 -43.943 -22.208 0.25 49.75  ? 801  HIS   A CD2 1 
ATOM   3967 C  CE1 . HIS   A 1 538 ? -23.779 -44.590 -20.291 0.25 50.28  ? 801  HIS   A CE1 1 
ATOM   3968 N  NE2 . HIS   A 1 538 ? -23.792 -43.600 -21.192 0.25 49.69  ? 801  HIS   A NE2 1 
ATOM   3969 N  N   . GLU   A 1 539 ? -26.066 -48.574 -25.367 0.25 37.74  ? 802  GLU   A N   1 
ATOM   3970 C  CA  . GLU   A 1 539 ? -26.944 -49.595 -25.999 0.25 37.02  ? 802  GLU   A CA  1 
ATOM   3971 C  C   . GLU   A 1 539 ? -27.271 -50.699 -24.982 0.25 36.21  ? 802  GLU   A C   1 
ATOM   3972 O  O   . GLU   A 1 539 ? -28.248 -51.436 -25.210 0.25 34.20  ? 802  GLU   A O   1 
ATOM   3973 C  CB  . GLU   A 1 539 ? -26.273 -50.176 -27.244 0.25 38.33  ? 802  GLU   A CB  1 
ATOM   3974 C  CG  . GLU   A 1 539 ? -26.239 -49.224 -28.427 0.25 39.16  ? 802  GLU   A CG  1 
ATOM   3975 C  CD  . GLU   A 1 539 ? -25.135 -48.182 -28.399 0.25 40.15  ? 802  GLU   A CD  1 
ATOM   3976 O  OE1 . GLU   A 1 539 ? -24.840 -47.611 -29.467 0.25 38.62  ? 802  GLU   A OE1 1 
ATOM   3977 O  OE2 . GLU   A 1 539 ? -24.571 -47.945 -27.315 0.25 43.88  ? 802  GLU   A OE2 1 
ATOM   3978 N  N   . TRP   A 1 540 ? -26.479 -50.802 -23.910 1.00 31.15  ? 803  TRP   A N   1 
ATOM   3979 C  CA  . TRP   A 1 540 ? -26.696 -51.841 -22.875 1.00 33.60  ? 803  TRP   A CA  1 
ATOM   3980 C  C   . TRP   A 1 540 ? -27.864 -51.458 -21.947 1.00 33.28  ? 803  TRP   A C   1 
ATOM   3981 O  O   . TRP   A 1 540 ? -28.315 -52.316 -21.181 1.00 31.82  ? 803  TRP   A O   1 
ATOM   3982 C  CB  . TRP   A 1 540 ? -25.391 -52.097 -22.101 1.00 33.17  ? 803  TRP   A CB  1 
ATOM   3983 C  CG  . TRP   A 1 540 ? -24.782 -50.877 -21.487 1.00 25.23  ? 803  TRP   A CG  1 
ATOM   3984 C  CD1 . TRP   A 1 540 ? -25.063 -50.335 -20.268 1.00 27.83  ? 803  TRP   A CD1 1 
ATOM   3985 C  CD2 . TRP   A 1 540 ? -23.759 -50.053 -22.066 1.00 26.22  ? 803  TRP   A CD2 1 
ATOM   3986 N  NE1 . TRP   A 1 540 ? -24.294 -49.226 -20.053 1.00 29.71  ? 803  TRP   A NE1 1 
ATOM   3987 C  CE2 . TRP   A 1 540 ? -23.479 -49.033 -21.135 1.00 28.23  ? 803  TRP   A CE2 1 
ATOM   3988 C  CE3 . TRP   A 1 540 ? -23.054 -50.082 -23.271 1.00 30.26  ? 803  TRP   A CE3 1 
ATOM   3989 C  CZ2 . TRP   A 1 540 ? -22.529 -48.047 -21.383 1.00 33.50  ? 803  TRP   A CZ2 1 
ATOM   3990 C  CZ3 . TRP   A 1 540 ? -22.120 -49.104 -23.517 1.00 35.04  ? 803  TRP   A CZ3 1 
ATOM   3991 C  CH2 . TRP   A 1 540 ? -21.860 -48.104 -22.582 1.00 31.12  ? 803  TRP   A CH2 1 
ATOM   3992 N  N   . MET   A 1 541 ? -28.318 -50.216 -21.986 1.00 31.97  ? 804  MET   A N   1 
ATOM   3993 C  CA  . MET   A 1 541 ? -29.408 -49.881 -21.051 1.00 33.00  ? 804  MET   A CA  1 
ATOM   3994 C  C   . MET   A 1 541 ? -30.744 -50.264 -21.707 1.00 37.79  ? 804  MET   A C   1 
ATOM   3995 O  O   . MET   A 1 541 ? -31.373 -49.372 -22.313 1.00 35.45  ? 804  MET   A O   1 
ATOM   3996 C  CB  . MET   A 1 541 ? -29.390 -48.401 -20.659 1.00 37.78  ? 804  MET   A CB  1 
ATOM   3997 C  CG  . MET   A 1 541 ? -28.076 -47.949 -20.051 1.00 43.64  ? 804  MET   A CG  1 
ATOM   3998 S  SD  . MET   A 1 541 ? -27.721 -48.698 -18.447 1.00 38.72  ? 804  MET   A SD  1 
ATOM   3999 C  CE  . MET   A 1 541 ? -28.997 -47.948 -17.441 1.00 40.01  ? 804  MET   A CE  1 
ATOM   4000 N  N   . THR   A 1 542 ? -31.142 -51.531 -21.613 0.25 35.03  ? 805  THR   A N   1 
ATOM   4001 C  CA  . THR   A 1 542 ? -32.367 -51.981 -22.322 0.25 35.60  ? 805  THR   A CA  1 
ATOM   4002 C  C   . THR   A 1 542 ? -32.789 -53.359 -21.820 0.25 34.39  ? 805  THR   A C   1 
ATOM   4003 O  O   . THR   A 1 542 ? -31.988 -54.005 -21.126 0.25 33.20  ? 805  THR   A O   1 
ATOM   4004 C  CB  . THR   A 1 542 ? -32.129 -52.043 -23.835 0.25 37.09  ? 805  THR   A CB  1 
ATOM   4005 O  OG1 . THR   A 1 542 ? -33.304 -52.566 -24.455 0.25 37.94  ? 805  THR   A OG1 1 
ATOM   4006 C  CG2 . THR   A 1 542 ? -30.935 -52.897 -24.203 0.25 38.29  ? 805  THR   A CG2 1 
ATOM   4007 N  N   . THR   A 1 543 ? -34.008 -53.774 -22.156 1.00 31.93  ? 806  THR   A N   1 
ATOM   4008 C  CA  . THR   A 1 543 ? -34.483 -55.132 -21.783 1.00 33.15  ? 806  THR   A CA  1 
ATOM   4009 C  C   . THR   A 1 543 ? -34.557 -56.022 -23.035 1.00 31.37  ? 806  THR   A C   1 
ATOM   4010 O  O   . THR   A 1 543 ? -34.861 -57.195 -22.894 1.00 33.29  ? 806  THR   A O   1 
ATOM   4011 C  CB  . THR   A 1 543 ? -35.836 -55.031 -21.054 1.00 44.87  ? 806  THR   A CB  1 
ATOM   4012 O  OG1 . THR   A 1 543 ? -36.753 -54.365 -21.932 1.00 39.26  ? 806  THR   A OG1 1 
ATOM   4013 C  CG2 . THR   A 1 543 ? -35.707 -54.264 -19.748 1.00 45.56  ? 806  THR   A CG2 1 
ATOM   4014 N  N   . GLU   A 1 544 ? -34.243 -55.492 -24.214 1.00 31.86  ? 807  GLU   A N   1 
ATOM   4015 C  CA  . GLU   A 1 544 ? -34.051 -56.301 -25.438 1.00 33.15  ? 807  GLU   A CA  1 
ATOM   4016 C  C   . GLU   A 1 544 ? -32.962 -57.354 -25.185 1.00 35.03  ? 807  GLU   A C   1 
ATOM   4017 O  O   . GLU   A 1 544 ? -32.091 -57.164 -24.315 1.00 34.07  ? 807  GLU   A O   1 
ATOM   4018 C  CB  . GLU   A 1 544 ? -33.727 -55.377 -26.593 1.00 38.98  ? 807  GLU   A CB  1 
ATOM   4019 C  CG  . GLU   A 1 544 ? -33.549 -56.094 -27.891 1.00 49.78  ? 807  GLU   A CG  1 
ATOM   4020 C  CD  . GLU   A 1 544 ? -33.686 -55.132 -29.058 1.00 59.34  ? 807  GLU   A CD  1 
ATOM   4021 O  OE1 . GLU   A 1 544 ? -34.299 -55.540 -30.084 1.00 64.25  ? 807  GLU   A OE1 1 
ATOM   4022 O  OE2 . GLU   A 1 544 ? -33.239 -53.958 -28.907 1.00 49.98  ? 807  GLU   A OE2 1 
ATOM   4023 N  N   . ASP   A 1 545 ? -33.087 -58.476 -25.860 1.00 34.45  ? 808  ASP   A N   1 
ATOM   4024 C  CA  . ASP   A 1 545 ? -32.159 -59.626 -25.815 1.00 39.54  ? 808  ASP   A CA  1 
ATOM   4025 C  C   . ASP   A 1 545 ? -30.753 -59.141 -26.242 1.00 36.09  ? 808  ASP   A C   1 
ATOM   4026 O  O   . ASP   A 1 545 ? -30.644 -58.462 -27.291 1.00 29.92  ? 808  ASP   A O   1 
ATOM   4027 C  CB  . ASP   A 1 545 ? -32.744 -60.701 -26.720 1.00 46.96  ? 808  ASP   A CB  1 
ATOM   4028 C  CG  . ASP   A 1 545 ? -31.919 -61.956 -26.820 1.00 53.95  ? 808  ASP   A CG  1 
ATOM   4029 O  OD1 . ASP   A 1 545 ? -30.972 -61.942 -27.600 1.00 55.98  ? 808  ASP   A OD1 1 
ATOM   4030 O  OD2 . ASP   A 1 545 ? -32.245 -62.923 -26.110 1.00 77.85  ? 808  ASP   A OD2 1 
ATOM   4031 N  N   . MET   A 1 546 ? -29.706 -59.467 -25.469 1.00 31.91  ? 809  MET   A N   1 
ATOM   4032 C  CA  . MET   A 1 546 ? -28.342 -58.881 -25.693 1.00 30.05  ? 809  MET   A CA  1 
ATOM   4033 C  C   . MET   A 1 546 ? -27.747 -59.438 -26.983 1.00 29.10  ? 809  MET   A C   1 
ATOM   4034 O  O   . MET   A 1 546 ? -26.983 -58.712 -27.604 1.00 26.60  ? 809  MET   A O   1 
ATOM   4035 C  CB  . MET   A 1 546 ? -27.389 -59.107 -24.513 1.00 33.44  ? 809  MET   A CB  1 
ATOM   4036 C  CG  . MET   A 1 546 ? -27.693 -58.182 -23.345 1.00 31.44  ? 809  MET   A CG  1 
ATOM   4037 S  SD  . MET   A 1 546 ? -27.474 -56.409 -23.742 1.00 42.76  ? 809  MET   A SD  1 
ATOM   4038 C  CE  . MET   A 1 546 ? -29.116 -55.794 -23.920 1.00 43.37  ? 809  MET   A CE  1 
ATOM   4039 N  N   . LEU   A 1 547 ? -28.144 -60.624 -27.441 1.00 24.87  ? 810  LEU   A N   1 
ATOM   4040 C  CA  . LEU   A 1 547 ? -27.615 -61.123 -28.739 1.00 29.91  ? 810  LEU   A CA  1 
ATOM   4041 C  C   . LEU   A 1 547 ? -28.168 -60.257 -29.875 1.00 31.71  ? 810  LEU   A C   1 
ATOM   4042 O  O   . LEU   A 1 547 ? -27.422 -59.992 -30.841 1.00 29.37  ? 810  LEU   A O   1 
ATOM   4043 C  CB  . LEU   A 1 547 ? -27.926 -62.594 -28.991 1.00 30.90  ? 810  LEU   A CB  1 
ATOM   4044 C  CG  . LEU   A 1 547 ? -27.239 -63.180 -30.240 1.00 33.09  ? 810  LEU   A CG  1 
ATOM   4045 C  CD1 . LEU   A 1 547 ? -25.708 -63.195 -30.127 1.00 33.63  ? 810  LEU   A CD1 1 
ATOM   4046 C  CD2 . LEU   A 1 547 ? -27.696 -64.593 -30.483 1.00 33.43  ? 810  LEU   A CD2 1 
ATOM   4047 N  N   . THR   A 1 548 ? -29.417 -59.821 -29.763 1.00 29.87  ? 811  THR   A N   1 
ATOM   4048 C  CA  . THR   A 1 548 ? -30.064 -58.971 -30.782 1.00 33.40  ? 811  THR   A CA  1 
ATOM   4049 C  C   . THR   A 1 548 ? -29.353 -57.607 -30.782 1.00 29.11  ? 811  THR   A C   1 
ATOM   4050 O  O   . THR   A 1 548 ? -29.076 -57.069 -31.830 1.00 27.62  ? 811  THR   A O   1 
ATOM   4051 C  CB  . THR   A 1 548 ? -31.585 -58.872 -30.531 1.00 35.07  ? 811  THR   A CB  1 
ATOM   4052 O  OG1 . THR   A 1 548 ? -32.142 -60.197 -30.632 1.00 32.46  ? 811  THR   A OG1 1 
ATOM   4053 C  CG2 . THR   A 1 548 ? -32.251 -57.948 -31.527 1.00 33.84  ? 811  THR   A CG2 1 
ATOM   4054 N  N   . VAL   A 1 549 ? -29.128 -57.026 -29.622 1.00 27.51  ? 812  VAL   A N   1 
ATOM   4055 C  CA  . VAL   A 1 549 ? -28.382 -55.746 -29.508 1.00 29.52  ? 812  VAL   A CA  1 
ATOM   4056 C  C   . VAL   A 1 549 ? -26.961 -55.934 -30.066 1.00 27.24  ? 812  VAL   A C   1 
ATOM   4057 O  O   . VAL   A 1 549 ? -26.475 -55.001 -30.749 1.00 27.28  ? 812  VAL   A O   1 
ATOM   4058 C  CB  . VAL   A 1 549 ? -28.379 -55.214 -28.067 1.00 29.37  ? 812  VAL   A CB  1 
ATOM   4059 C  CG1 . VAL   A 1 549 ? -27.625 -53.882 -27.989 1.00 31.84  ? 812  VAL   A CG1 1 
ATOM   4060 C  CG2 . VAL   A 1 549 ? -29.807 -55.055 -27.558 1.00 35.11  ? 812  VAL   A CG2 1 
ATOM   4061 N  N   . TRP   A 1 550 ? -26.270 -57.040 -29.746 1.00 26.11  ? 813  TRP   A N   1 
ATOM   4062 C  CA  . TRP   A 1 550 ? -24.886 -57.270 -30.242 1.00 25.13  ? 813  TRP   A CA  1 
ATOM   4063 C  C   . TRP   A 1 550 ? -24.913 -57.219 -31.780 1.00 29.51  ? 813  TRP   A C   1 
ATOM   4064 O  O   . TRP   A 1 550 ? -24.066 -56.522 -32.399 1.00 27.96  ? 813  TRP   A O   1 
ATOM   4065 C  CB  . TRP   A 1 550 ? -24.282 -58.570 -29.689 1.00 23.22  ? 813  TRP   A CB  1 
ATOM   4066 C  CG  . TRP   A 1 550 ? -22.819 -58.708 -29.955 1.00 24.94  ? 813  TRP   A CG  1 
ATOM   4067 C  CD1 . TRP   A 1 550 ? -21.786 -58.483 -29.069 1.00 26.78  ? 813  TRP   A CD1 1 
ATOM   4068 C  CD2 . TRP   A 1 550 ? -22.197 -59.104 -31.179 1.00 24.25  ? 813  TRP   A CD2 1 
ATOM   4069 N  NE1 . TRP   A 1 550 ? -20.568 -58.735 -29.630 1.00 24.75  ? 813  TRP   A NE1 1 
ATOM   4070 C  CE2 . TRP   A 1 550 ? -20.788 -59.119 -30.939 1.00 26.09  ? 813  TRP   A CE2 1 
ATOM   4071 C  CE3 . TRP   A 1 550 ? -22.680 -59.561 -32.405 1.00 27.93  ? 813  TRP   A CE3 1 
ATOM   4072 C  CZ2 . TRP   A 1 550 ? -19.867 -59.489 -31.908 1.00 25.73  ? 813  TRP   A CZ2 1 
ATOM   4073 C  CZ3 . TRP   A 1 550 ? -21.756 -59.873 -33.387 1.00 26.41  ? 813  TRP   A CZ3 1 
ATOM   4074 C  CH2 . TRP   A 1 550 ? -20.381 -59.864 -33.132 1.00 25.59  ? 813  TRP   A CH2 1 
ATOM   4075 N  N   . ASN   A 1 551 ? -25.866 -57.916 -32.402 1.00 29.21  ? 814  ASN   A N   1 
ATOM   4076 C  CA  . ASN   A 1 551 ? -25.967 -57.970 -33.882 1.00 29.26  ? 814  ASN   A CA  1 
ATOM   4077 C  C   . ASN   A 1 551 ? -26.195 -56.573 -34.432 1.00 26.77  ? 814  ASN   A C   1 
ATOM   4078 O  O   . ASN   A 1 551 ? -25.596 -56.248 -35.467 1.00 28.45  ? 814  ASN   A O   1 
ATOM   4079 C  CB  . ASN   A 1 551 ? -27.053 -58.920 -34.407 1.00 32.30  ? 814  ASN   A CB  1 
ATOM   4080 C  CG  . ASN   A 1 551 ? -26.522 -60.319 -34.583 1.00 33.65  ? 814  ASN   A CG  1 
ATOM   4081 O  OD1 . ASN   A 1 551 ? -25.594 -60.548 -35.366 1.00 40.21  ? 814  ASN   A OD1 1 
ATOM   4082 N  ND2 . ASN   A 1 551 ? -27.102 -61.281 -33.880 1.00 43.52  ? 814  ASN   A ND2 1 
ATOM   4083 N  N   . ARG   A 1 552 ? -27.047 -55.785 -33.808 1.00 28.58  ? 815  ARG   A N   1 
ATOM   4084 C  CA  . ARG   A 1 552 ? -27.329 -54.439 -34.323 1.00 27.79  ? 815  ARG   A CA  1 
ATOM   4085 C  C   . ARG   A 1 552 ? -26.050 -53.574 -34.270 1.00 32.06  ? 815  ARG   A C   1 
ATOM   4086 O  O   . ARG   A 1 552 ? -25.769 -52.857 -35.237 1.00 33.79  ? 815  ARG   A O   1 
ATOM   4087 C  CB  . ARG   A 1 552 ? -28.482 -53.826 -33.541 1.00 30.96  ? 815  ARG   A CB  1 
ATOM   4088 C  CG  . ARG   A 1 552 ? -28.953 -52.496 -34.108 1.00 34.77  ? 815  ARG   A CG  1 
ATOM   4089 C  CD  . ARG   A 1 552 ? -29.981 -51.825 -33.198 1.00 41.70  ? 815  ARG   A CD  1 
ATOM   4090 N  NE  . ARG   A 1 552 ? -31.141 -52.712 -33.157 1.00 52.67  ? 815  ARG   A NE  1 
ATOM   4091 C  CZ  . ARG   A 1 552 ? -31.743 -53.212 -32.066 1.00 53.56  ? 815  ARG   A CZ  1 
ATOM   4092 N  NH1 . ARG   A 1 552 ? -31.381 -52.880 -30.835 1.00 46.83  ? 815  ARG   A NH1 1 
ATOM   4093 N  NH2 . ARG   A 1 552 ? -32.785 -53.998 -32.248 1.00 60.40  ? 815  ARG   A NH2 1 
ATOM   4094 N  N   . VAL   A 1 553 ? -25.319 -53.589 -33.157 1.00 27.55  ? 816  VAL   A N   1 
ATOM   4095 C  CA  . VAL   A 1 553 ? -24.193 -52.657 -32.892 1.00 26.10  ? 816  VAL   A CA  1 
ATOM   4096 C  C   . VAL   A 1 553 ? -22.964 -53.075 -33.713 1.00 25.68  ? 816  VAL   A C   1 
ATOM   4097 O  O   . VAL   A 1 553 ? -22.323 -52.201 -34.320 1.00 31.35  ? 816  VAL   A O   1 
ATOM   4098 C  CB  . VAL   A 1 553 ? -23.922 -52.612 -31.375 1.00 29.93  ? 816  VAL   A CB  1 
ATOM   4099 C  CG1 . VAL   A 1 553 ? -22.615 -51.953 -31.077 1.00 32.25  ? 816  VAL   A CG1 1 
ATOM   4100 C  CG2 . VAL   A 1 553 ? -25.053 -51.884 -30.669 1.00 28.21  ? 816  VAL   A CG2 1 
ATOM   4101 N  N   . TRP   A 1 554 ? -22.606 -54.365 -33.724 1.00 24.49  ? 817  TRP   A N   1 
ATOM   4102 C  CA  . TRP   A 1 554 ? -21.313 -54.868 -34.236 1.00 23.33  ? 817  TRP   A CA  1 
ATOM   4103 C  C   . TRP   A 1 554 ? -21.453 -55.286 -35.694 1.00 27.61  ? 817  TRP   A C   1 
ATOM   4104 O  O   . TRP   A 1 554 ? -20.415 -55.343 -36.335 1.00 29.73  ? 817  TRP   A O   1 
ATOM   4105 C  CB  . TRP   A 1 554 ? -20.781 -56.030 -33.385 1.00 27.04  ? 817  TRP   A CB  1 
ATOM   4106 C  CG  . TRP   A 1 554 ? -20.289 -55.581 -32.034 1.00 25.46  ? 817  TRP   A CG  1 
ATOM   4107 C  CD1 . TRP   A 1 554 ? -20.912 -55.650 -30.833 1.00 25.59  ? 817  TRP   A CD1 1 
ATOM   4108 C  CD2 . TRP   A 1 554 ? -19.071 -54.845 -31.822 1.00 24.04  ? 817  TRP   A CD2 1 
ATOM   4109 N  NE1 . TRP   A 1 554 ? -20.135 -55.065 -29.863 1.00 25.05  ? 817  TRP   A NE1 1 
ATOM   4110 C  CE2 . TRP   A 1 554 ? -18.994 -54.562 -30.448 1.00 23.64  ? 817  TRP   A CE2 1 
ATOM   4111 C  CE3 . TRP   A 1 554 ? -18.055 -54.413 -32.679 1.00 25.18  ? 817  TRP   A CE3 1 
ATOM   4112 C  CZ2 . TRP   A 1 554 ? -17.925 -53.866 -29.912 1.00 22.25  ? 817  TRP   A CZ2 1 
ATOM   4113 C  CZ3 . TRP   A 1 554 ? -16.978 -53.713 -32.138 1.00 25.59  ? 817  TRP   A CZ3 1 
ATOM   4114 C  CH2 . TRP   A 1 554 ? -16.910 -53.497 -30.768 1.00 23.94  ? 817  TRP   A CH2 1 
ATOM   4115 N  N   . ILE   A 1 555 ? -22.678 -55.556 -36.193 1.00 30.06  ? 818  ILE   A N   1 
ATOM   4116 C  CA  . ILE   A 1 555 ? -22.885 -56.037 -37.593 1.00 29.23  ? 818  ILE   A CA  1 
ATOM   4117 C  C   . ILE   A 1 555 ? -23.748 -55.041 -38.363 1.00 31.43  ? 818  ILE   A C   1 
ATOM   4118 O  O   . ILE   A 1 555 ? -23.201 -54.354 -39.257 1.00 28.96  ? 818  ILE   A O   1 
ATOM   4119 C  CB  . ILE   A 1 555 ? -23.529 -57.428 -37.635 1.00 30.97  ? 818  ILE   A CB  1 
ATOM   4120 C  CG1 . ILE   A 1 555 ? -22.781 -58.453 -36.797 1.00 33.44  ? 818  ILE   A CG1 1 
ATOM   4121 C  CG2 . ILE   A 1 555 ? -23.646 -57.887 -39.097 1.00 33.80  ? 818  ILE   A CG2 1 
ATOM   4122 C  CD1 . ILE   A 1 555 ? -21.360 -58.553 -37.144 1.00 37.11  ? 818  ILE   A CD1 1 
ATOM   4123 N  N   . GLN   A 1 556 ? -25.041 -54.931 -38.029 1.00 33.48  ? 819  GLN   A N   1 
ATOM   4124 C  CA  . GLN   A 1 556 ? -26.032 -54.233 -38.903 1.00 37.97  ? 819  GLN   A CA  1 
ATOM   4125 C  C   . GLN   A 1 556 ? -25.640 -52.755 -39.048 1.00 37.44  ? 819  GLN   A C   1 
ATOM   4126 O  O   . GLN   A 1 556 ? -25.545 -52.286 -40.189 1.00 34.68  ? 819  GLN   A O   1 
ATOM   4127 C  CB  . GLN   A 1 556 ? -27.446 -54.415 -38.348 1.00 42.50  ? 819  GLN   A CB  1 
ATOM   4128 C  CG  . GLN   A 1 556 ? -28.544 -53.763 -39.183 1.00 51.69  ? 819  GLN   A CG  1 
ATOM   4129 C  CD  . GLN   A 1 556 ? -29.817 -53.555 -38.386 1.00 62.30  ? 819  GLN   A CD  1 
ATOM   4130 O  OE1 . GLN   A 1 556 ? -30.457 -52.505 -38.459 1.00 70.78  ? 819  GLN   A OE1 1 
ATOM   4131 N  NE2 . GLN   A 1 556 ? -30.172 -54.537 -37.569 1.00 57.90  ? 819  GLN   A NE2 1 
ATOM   4132 N  N   . GLU   A 1 557 ? -25.378 -52.055 -37.944 1.00 29.88  ? 820  GLU   A N   1 
ATOM   4133 C  CA  . GLU   A 1 557 ? -25.129 -50.594 -37.948 1.00 32.33  ? 820  GLU   A CA  1 
ATOM   4134 C  C   . GLU   A 1 557 ? -23.624 -50.268 -37.955 1.00 33.61  ? 820  GLU   A C   1 
ATOM   4135 O  O   . GLU   A 1 557 ? -23.276 -49.067 -37.880 1.00 36.60  ? 820  GLU   A O   1 
ATOM   4136 C  CB  . GLU   A 1 557 ? -25.870 -49.937 -36.794 1.00 33.74  ? 820  GLU   A CB  1 
ATOM   4137 C  CG  . GLU   A 1 557 ? -27.349 -50.287 -36.765 1.00 44.42  ? 820  GLU   A CG  1 
ATOM   4138 C  CD  . GLU   A 1 557 ? -28.202 -49.511 -35.756 1.00 56.33  ? 820  GLU   A CD  1 
ATOM   4139 O  OE1 . GLU   A 1 557 ? -27.657 -49.007 -34.735 1.00 55.07  ? 820  GLU   A OE1 1 
ATOM   4140 O  OE2 . GLU   A 1 557 ? -29.440 -49.422 -35.980 1.00 71.39  ? 820  GLU   A OE2 1 
ATOM   4141 N  N   . ASN   A 1 558 ? -22.756 -51.269 -38.101 1.00 31.83  ? 821  ASN   A N   1 
ATOM   4142 C  CA  . ASN   A 1 558 ? -21.282 -51.077 -38.103 1.00 32.71  ? 821  ASN   A CA  1 
ATOM   4143 C  C   . ASN   A 1 558 ? -20.818 -50.645 -39.499 1.00 30.48  ? 821  ASN   A C   1 
ATOM   4144 O  O   . ASN   A 1 558 ? -20.710 -51.459 -40.377 1.00 31.64  ? 821  ASN   A O   1 
ATOM   4145 C  CB  . ASN   A 1 558 ? -20.608 -52.361 -37.636 1.00 31.82  ? 821  ASN   A CB  1 
ATOM   4146 C  CG  . ASN   A 1 558 ? -19.100 -52.271 -37.536 1.00 31.95  ? 821  ASN   A CG  1 
ATOM   4147 O  OD1 . ASN   A 1 558 ? -18.521 -51.280 -37.959 1.00 29.65  ? 821  ASN   A OD1 1 
ATOM   4148 N  ND2 . ASN   A 1 558 ? -18.472 -53.329 -37.012 1.00 27.80  ? 821  ASN   A ND2 1 
ATOM   4149 N  N   . PRO   A 1 559 ? -20.450 -49.380 -39.755 1.00 32.22  ? 822  PRO   A N   1 
ATOM   4150 C  CA  . PRO   A 1 559 ? -20.033 -48.994 -41.105 1.00 36.30  ? 822  PRO   A CA  1 
ATOM   4151 C  C   . PRO   A 1 559 ? -18.713 -49.631 -41.558 1.00 35.45  ? 822  PRO   A C   1 
ATOM   4152 O  O   . PRO   A 1 559 ? -18.432 -49.611 -42.724 1.00 33.83  ? 822  PRO   A O   1 
ATOM   4153 C  CB  . PRO   A 1 559 ? -19.955 -47.467 -41.034 1.00 38.40  ? 822  PRO   A CB  1 
ATOM   4154 C  CG  . PRO   A 1 559 ? -19.763 -47.164 -39.556 1.00 38.10  ? 822  PRO   A CG  1 
ATOM   4155 C  CD  . PRO   A 1 559 ? -20.541 -48.243 -38.831 1.00 37.07  ? 822  PRO   A CD  1 
ATOM   4156 N  N   . TRP   A 1 560 ? -17.937 -50.257 -40.670 1.00 34.25  ? 823  TRP   A N   1 
ATOM   4157 C  CA  . TRP   A 1 560 ? -16.682 -50.947 -41.082 1.00 33.29  ? 823  TRP   A CA  1 
ATOM   4158 C  C   . TRP   A 1 560 ? -16.912 -52.422 -41.440 1.00 33.81  ? 823  TRP   A C   1 
ATOM   4159 O  O   . TRP   A 1 560 ? -15.930 -53.048 -41.802 1.00 38.34  ? 823  TRP   A O   1 
ATOM   4160 C  CB  . TRP   A 1 560 ? -15.608 -50.785 -39.986 1.00 31.01  ? 823  TRP   A CB  1 
ATOM   4161 C  CG  . TRP   A 1 560 ? -15.154 -49.362 -39.871 1.00 30.12  ? 823  TRP   A CG  1 
ATOM   4162 C  CD1 . TRP   A 1 560 ? -14.236 -48.725 -40.646 1.00 29.05  ? 823  TRP   A CD1 1 
ATOM   4163 C  CD2 . TRP   A 1 560 ? -15.674 -48.378 -38.970 1.00 29.59  ? 823  TRP   A CD2 1 
ATOM   4164 N  NE1 . TRP   A 1 560 ? -14.099 -47.425 -40.226 1.00 31.94  ? 823  TRP   A NE1 1 
ATOM   4165 C  CE2 . TRP   A 1 560 ? -15.000 -47.175 -39.225 1.00 29.79  ? 823  TRP   A CE2 1 
ATOM   4166 C  CE3 . TRP   A 1 560 ? -16.596 -48.419 -37.924 1.00 27.82  ? 823  TRP   A CE3 1 
ATOM   4167 C  CZ2 . TRP   A 1 560 ? -15.204 -46.030 -38.456 1.00 31.88  ? 823  TRP   A CZ2 1 
ATOM   4168 C  CZ3 . TRP   A 1 560 ? -16.845 -47.282 -37.210 1.00 28.27  ? 823  TRP   A CZ3 1 
ATOM   4169 C  CH2 . TRP   A 1 560 ? -16.153 -46.093 -37.474 1.00 29.88  ? 823  TRP   A CH2 1 
ATOM   4170 N  N   . MET   A 1 561 ? -18.135 -52.958 -41.327 1.00 33.82  ? 824  MET   A N   1 
ATOM   4171 C  CA  . MET   A 1 561 ? -18.469 -54.403 -41.566 1.00 33.03  ? 824  MET   A CA  1 
ATOM   4172 C  C   . MET   A 1 561 ? -19.283 -54.478 -42.866 1.00 31.87  ? 824  MET   A C   1 
ATOM   4173 O  O   . MET   A 1 561 ? -20.451 -54.043 -42.866 1.00 33.35  ? 824  MET   A O   1 
ATOM   4174 C  CB  . MET   A 1 561 ? -19.304 -54.935 -40.392 1.00 34.44  ? 824  MET   A CB  1 
ATOM   4175 C  CG  . MET   A 1 561 ? -19.569 -56.452 -40.359 1.00 38.91  ? 824  MET   A CG  1 
ATOM   4176 S  SD  . MET   A 1 561 ? -18.053 -57.323 -40.051 1.00 52.44  ? 824  MET   A SD  1 
ATOM   4177 C  CE  . MET   A 1 561 ? -17.878 -57.099 -38.275 1.00 51.34  ? 824  MET   A CE  1 
ATOM   4178 N  N   . GLU   A 1 562 ? -18.694 -54.935 -43.965 1.00 38.58  ? 825  GLU   A N   1 
ATOM   4179 C  CA  . GLU   A 1 562 ? -19.424 -54.970 -45.263 1.00 45.66  ? 825  GLU   A CA  1 
ATOM   4180 C  C   . GLU   A 1 562 ? -20.432 -56.139 -45.288 1.00 39.58  ? 825  GLU   A C   1 
ATOM   4181 O  O   . GLU   A 1 562 ? -21.548 -55.913 -45.739 1.00 43.83  ? 825  GLU   A O   1 
ATOM   4182 C  CB  . GLU   A 1 562 ? -18.472 -55.013 -46.463 1.00 55.13  ? 825  GLU   A CB  1 
ATOM   4183 C  CG  . GLU   A 1 562 ? -19.147 -54.571 -47.752 1.00 71.40  ? 825  GLU   A CG  1 
ATOM   4184 C  CD  . GLU   A 1 562 ? -18.514 -55.079 -49.042 1.00 86.23  ? 825  GLU   A CD  1 
ATOM   4185 O  OE1 . GLU   A 1 562 ? -19.182 -54.964 -50.111 1.00 89.84  ? 825  GLU   A OE1 1 
ATOM   4186 O  OE2 . GLU   A 1 562 ? -17.355 -55.577 -48.984 1.00 87.77  ? 825  GLU   A OE2 1 
ATOM   4187 N  N   . ASP   A 1 563 ? -20.076 -57.325 -44.807 1.00 37.79  ? 826  ASP   A N   1 
ATOM   4188 C  CA  . ASP   A 1 563 ? -20.966 -58.514 -44.777 1.00 36.42  ? 826  ASP   A CA  1 
ATOM   4189 C  C   . ASP   A 1 563 ? -21.933 -58.386 -43.605 1.00 38.51  ? 826  ASP   A C   1 
ATOM   4190 O  O   . ASP   A 1 563 ? -21.454 -58.337 -42.437 1.00 39.94  ? 826  ASP   A O   1 
ATOM   4191 C  CB  . ASP   A 1 563 ? -20.091 -59.751 -44.643 1.00 38.72  ? 826  ASP   A CB  1 
ATOM   4192 C  CG  . ASP   A 1 563 ? -20.838 -61.066 -44.548 1.00 36.45  ? 826  ASP   A CG  1 
ATOM   4193 O  OD1 . ASP   A 1 563 ? -22.074 -61.034 -44.467 1.00 39.30  ? 826  ASP   A OD1 1 
ATOM   4194 O  OD2 . ASP   A 1 563 ? -20.159 -62.076 -44.432 1.00 43.64  ? 826  ASP   A OD2 1 
ATOM   4195 N  N   . LYS   A 1 564 ? -23.227 -58.302 -43.868 1.00 33.96  ? 827  LYS   A N   1 
ATOM   4196 C  CA  . LYS   A 1 564 ? -24.246 -58.034 -42.826 1.00 34.56  ? 827  LYS   A CA  1 
ATOM   4197 C  C   . LYS   A 1 564 ? -24.873 -59.350 -42.332 1.00 30.84  ? 827  LYS   A C   1 
ATOM   4198 O  O   . LYS   A 1 564 ? -25.913 -59.286 -41.642 1.00 34.68  ? 827  LYS   A O   1 
ATOM   4199 C  CB  . LYS   A 1 564 ? -25.301 -57.027 -43.302 1.00 34.58  ? 827  LYS   A CB  1 
ATOM   4200 C  CG  . LYS   A 1 564 ? -24.758 -55.663 -43.690 1.00 38.23  ? 827  LYS   A CG  1 
ATOM   4201 C  CD  . LYS   A 1 564 ? -23.926 -55.008 -42.632 1.00 31.70  ? 827  LYS   A CD  1 
ATOM   4202 C  CE  . LYS   A 1 564 ? -23.700 -53.553 -42.923 1.00 31.73  ? 827  LYS   A CE  1 
ATOM   4203 N  NZ  . LYS   A 1 564 ? -22.835 -52.977 -41.862 1.00 32.56  ? 827  LYS   A NZ  1 
ATOM   4204 N  N   . THR   A 1 565 ? -24.250 -60.498 -42.564 1.00 30.74  ? 828  THR   A N   1 
ATOM   4205 C  CA  . THR   A 1 565 ? -24.844 -61.788 -42.106 1.00 32.87  ? 828  THR   A CA  1 
ATOM   4206 C  C   . THR   A 1 565 ? -24.951 -61.787 -40.578 1.00 37.02  ? 828  THR   A C   1 
ATOM   4207 O  O   . THR   A 1 565 ? -23.920 -61.682 -39.914 1.00 34.55  ? 828  THR   A O   1 
ATOM   4208 C  CB  . THR   A 1 565 ? -23.972 -62.978 -42.521 1.00 36.02  ? 828  THR   A CB  1 
ATOM   4209 O  OG1 . THR   A 1 565 ? -23.798 -62.890 -43.934 1.00 37.01  ? 828  THR   A OG1 1 
ATOM   4210 C  CG2 . THR   A 1 565 ? -24.539 -64.318 -42.116 1.00 38.84  ? 828  THR   A CG2 1 
ATOM   4211 N  N   . PRO   A 1 566 ? -26.163 -61.955 -39.985 1.00 39.25  ? 829  PRO   A N   1 
ATOM   4212 C  CA  . PRO   A 1 566 ? -26.321 -61.965 -38.532 1.00 39.29  ? 829  PRO   A CA  1 
ATOM   4213 C  C   . PRO   A 1 566 ? -25.571 -63.132 -37.894 1.00 40.00  ? 829  PRO   A C   1 
ATOM   4214 O  O   . PRO   A 1 566 ? -25.350 -64.163 -38.504 1.00 33.84  ? 829  PRO   A O   1 
ATOM   4215 C  CB  . PRO   A 1 566 ? -27.836 -62.118 -38.319 1.00 41.82  ? 829  PRO   A CB  1 
ATOM   4216 C  CG  . PRO   A 1 566 ? -28.468 -61.763 -39.656 1.00 40.09  ? 829  PRO   A CG  1 
ATOM   4217 C  CD  . PRO   A 1 566 ? -27.446 -62.182 -40.674 1.00 41.03  ? 829  PRO   A CD  1 
ATOM   4218 N  N   . VAL   A 1 567 ? -25.158 -62.941 -36.651 1.00 39.65  ? 830  VAL   A N   1 
ATOM   4219 C  CA  . VAL   A 1 567 ? -24.567 -64.032 -35.842 1.00 38.24  ? 830  VAL   A CA  1 
ATOM   4220 C  C   . VAL   A 1 567 ? -25.738 -64.727 -35.116 1.00 38.79  ? 830  VAL   A C   1 
ATOM   4221 O  O   . VAL   A 1 567 ? -26.630 -64.029 -34.637 1.00 36.83  ? 830  VAL   A O   1 
ATOM   4222 C  CB  . VAL   A 1 567 ? -23.533 -63.375 -34.912 1.00 40.81  ? 830  VAL   A CB  1 
ATOM   4223 C  CG1 . VAL   A 1 567 ? -23.363 -64.146 -33.663 1.00 38.74  ? 830  VAL   A CG1 1 
ATOM   4224 C  CG2 . VAL   A 1 567 ? -22.203 -63.185 -35.608 1.00 41.85  ? 830  VAL   A CG2 1 
ATOM   4225 N  N   . GLU   A 1 568 ? -25.765 -66.053 -35.043 1.00 38.75  ? 831  GLU   A N   1 
ATOM   4226 C  CA  . GLU   A 1 568 ? -26.977 -66.812 -34.604 1.00 43.94  ? 831  GLU   A CA  1 
ATOM   4227 C  C   . GLU   A 1 568 ? -26.825 -67.205 -33.138 1.00 41.82  ? 831  GLU   A C   1 
ATOM   4228 O  O   . GLU   A 1 568 ? -27.839 -67.479 -32.494 1.00 38.41  ? 831  GLU   A O   1 
ATOM   4229 C  CB  . GLU   A 1 568 ? -27.157 -68.095 -35.427 1.00 49.18  ? 831  GLU   A CB  1 
ATOM   4230 C  CG  . GLU   A 1 568 ? -27.477 -67.861 -36.907 1.00 52.39  ? 831  GLU   A CG  1 
ATOM   4231 C  CD  . GLU   A 1 568 ? -28.809 -67.172 -37.174 1.00 55.85  ? 831  GLU   A CD  1 
ATOM   4232 O  OE1 . GLU   A 1 568 ? -29.724 -67.278 -36.334 1.00 56.38  ? 831  GLU   A OE1 1 
ATOM   4233 O  OE2 . GLU   A 1 568 ? -28.928 -66.526 -38.219 1.00 65.67  ? 831  GLU   A OE2 1 
ATOM   4234 N  N   . SER   A 1 569 ? -25.598 -67.236 -32.616 1.00 34.32  ? 832  SER   A N   1 
ATOM   4235 C  CA  . SER   A 1 569 ? -25.367 -67.600 -31.205 1.00 28.26  ? 832  SER   A CA  1 
ATOM   4236 C  C   . SER   A 1 569 ? -24.082 -66.972 -30.656 1.00 29.85  ? 832  SER   A C   1 
ATOM   4237 O  O   . SER   A 1 569 ? -23.179 -66.548 -31.445 1.00 32.61  ? 832  SER   A O   1 
ATOM   4238 C  CB  . SER   A 1 569 ? -25.342 -69.082 -31.068 1.00 35.11  ? 832  SER   A CB  1 
ATOM   4239 O  OG  . SER   A 1 569 ? -24.046 -69.569 -31.318 1.00 35.01  ? 832  SER   A OG  1 
ATOM   4240 N  N   . TRP   A 1 570 ? -24.035 -66.839 -29.336 1.00 28.52  ? 833  TRP   A N   1 
ATOM   4241 C  CA  . TRP   A 1 570 ? -22.852 -66.279 -28.636 1.00 31.75  ? 833  TRP   A CA  1 
ATOM   4242 C  C   . TRP   A 1 570 ? -21.600 -67.104 -28.977 1.00 33.83  ? 833  TRP   A C   1 
ATOM   4243 O  O   . TRP   A 1 570 ? -20.535 -66.523 -29.040 1.00 29.31  ? 833  TRP   A O   1 
ATOM   4244 C  CB  . TRP   A 1 570 ? -23.132 -66.192 -27.123 1.00 28.72  ? 833  TRP   A CB  1 
ATOM   4245 C  CG  . TRP   A 1 570 ? -23.977 -65.023 -26.778 1.00 28.95  ? 833  TRP   A CG  1 
ATOM   4246 C  CD1 . TRP   A 1 570 ? -25.320 -65.035 -26.548 1.00 29.43  ? 833  TRP   A CD1 1 
ATOM   4247 C  CD2 . TRP   A 1 570 ? -23.552 -63.634 -26.682 1.00 29.33  ? 833  TRP   A CD2 1 
ATOM   4248 N  NE1 . TRP   A 1 570 ? -25.748 -63.762 -26.298 1.00 33.59  ? 833  TRP   A NE1 1 
ATOM   4249 C  CE2 . TRP   A 1 570 ? -24.695 -62.882 -26.373 1.00 29.27  ? 833  TRP   A CE2 1 
ATOM   4250 C  CE3 . TRP   A 1 570 ? -22.321 -62.962 -26.792 1.00 32.75  ? 833  TRP   A CE3 1 
ATOM   4251 C  CZ2 . TRP   A 1 570 ? -24.641 -61.502 -26.128 1.00 31.02  ? 833  TRP   A CZ2 1 
ATOM   4252 C  CZ3 . TRP   A 1 570 ? -22.261 -61.594 -26.597 1.00 29.08  ? 833  TRP   A CZ3 1 
ATOM   4253 C  CH2 . TRP   A 1 570 ? -23.421 -60.877 -26.264 1.00 31.13  ? 833  TRP   A CH2 1 
ATOM   4254 N  N   . GLU   A 1 571 ? -21.696 -68.384 -29.347 1.00 33.28  ? 834  GLU   A N   1 
ATOM   4255 C  CA  . GLU   A 1 571 ? -20.477 -69.211 -29.595 1.00 38.20  ? 834  GLU   A CA  1 
ATOM   4256 C  C   . GLU   A 1 571 ? -19.796 -68.779 -30.896 1.00 33.16  ? 834  GLU   A C   1 
ATOM   4257 O  O   . GLU   A 1 571 ? -18.623 -69.022 -31.023 1.00 37.55  ? 834  GLU   A O   1 
ATOM   4258 C  CB  . GLU   A 1 571 ? -20.831 -70.705 -29.582 1.00 49.73  ? 834  GLU   A CB  1 
ATOM   4259 C  CG  . GLU   A 1 571 ? -21.539 -71.091 -28.285 1.00 64.98  ? 834  GLU   A CG  1 
ATOM   4260 C  CD  . GLU   A 1 571 ? -21.604 -72.563 -27.889 1.00 84.99  ? 834  GLU   A CD  1 
ATOM   4261 O  OE1 . GLU   A 1 571 ? -20.640 -73.313 -28.187 1.00 94.07  ? 834  GLU   A OE1 1 
ATOM   4262 O  OE2 . GLU   A 1 571 ? -22.620 -72.953 -27.244 1.00 95.66  ? 834  GLU   A OE2 1 
ATOM   4263 N  N   . GLU   A 1 572 ? -20.480 -68.122 -31.804 1.00 32.73  ? 835  GLU   A N   1 
ATOM   4264 C  CA  . GLU   A 1 572 ? -19.834 -67.550 -33.015 1.00 34.82  ? 835  GLU   A CA  1 
ATOM   4265 C  C   . GLU   A 1 572 ? -19.001 -66.303 -32.640 1.00 32.50  ? 835  GLU   A C   1 
ATOM   4266 O  O   . GLU   A 1 572 ? -18.351 -65.718 -33.527 1.00 34.26  ? 835  GLU   A O   1 
ATOM   4267 C  CB  . GLU   A 1 572 ? -20.878 -67.049 -34.027 1.00 40.51  ? 835  GLU   A CB  1 
ATOM   4268 C  CG  . GLU   A 1 572 ? -21.630 -68.114 -34.805 1.00 49.03  ? 835  GLU   A CG  1 
ATOM   4269 C  CD  . GLU   A 1 572 ? -22.616 -67.509 -35.829 1.00 52.17  ? 835  GLU   A CD  1 
ATOM   4270 O  OE1 . GLU   A 1 572 ? -22.178 -66.809 -36.777 1.00 49.34  ? 835  GLU   A OE1 1 
ATOM   4271 O  OE2 . GLU   A 1 572 ? -23.828 -67.677 -35.660 1.00 49.06  ? 835  GLU   A OE2 1 
ATOM   4272 N  N   . ILE   A 1 573 ? -19.179 -65.772 -31.433 1.00 29.12  ? 836  ILE   A N   1 
ATOM   4273 C  CA  . ILE   A 1 573 ? -18.552 -64.470 -31.053 1.00 29.97  ? 836  ILE   A CA  1 
ATOM   4274 C  C   . ILE   A 1 573 ? -17.230 -64.793 -30.349 1.00 30.25  ? 836  ILE   A C   1 
ATOM   4275 O  O   . ILE   A 1 573 ? -17.227 -65.440 -29.293 1.00 27.06  ? 836  ILE   A O   1 
ATOM   4276 C  CB  . ILE   A 1 573 ? -19.521 -63.619 -30.219 1.00 29.34  ? 836  ILE   A CB  1 
ATOM   4277 C  CG1 . ILE   A 1 573 ? -20.731 -63.222 -31.056 1.00 28.03  ? 836  ILE   A CG1 1 
ATOM   4278 C  CG2 . ILE   A 1 573 ? -18.792 -62.384 -29.664 1.00 32.68  ? 836  ILE   A CG2 1 
ATOM   4279 C  CD1 . ILE   A 1 573 ? -21.845 -62.587 -30.293 1.00 27.73  ? 836  ILE   A CD1 1 
ATOM   4280 N  N   . PRO   A 1 574 ? -16.085 -64.341 -30.907 1.00 30.44  ? 837  PRO   A N   1 
ATOM   4281 C  CA  . PRO   A 1 574 ? -14.754 -64.737 -30.428 1.00 29.95  ? 837  PRO   A CA  1 
ATOM   4282 C  C   . PRO   A 1 574 ? -14.293 -64.049 -29.120 1.00 25.19  ? 837  PRO   A C   1 
ATOM   4283 O  O   . PRO   A 1 574 ? -14.860 -63.021 -28.698 1.00 24.40  ? 837  PRO   A O   1 
ATOM   4284 C  CB  . PRO   A 1 574 ? -13.862 -64.274 -31.597 1.00 30.80  ? 837  PRO   A CB  1 
ATOM   4285 C  CG  . PRO   A 1 574 ? -14.534 -63.012 -32.046 1.00 35.43  ? 837  PRO   A CG  1 
ATOM   4286 C  CD  . PRO   A 1 574 ? -16.020 -63.318 -31.966 1.00 34.30  ? 837  PRO   A CD  1 
ATOM   4287 N  N   . TYR   A 1 575 ? -13.302 -64.660 -28.480 1.00 25.47  ? 838  TYR   A N   1 
ATOM   4288 C  CA  . TYR   A 1 575 ? -12.481 -64.068 -27.397 1.00 23.97  ? 838  TYR   A CA  1 
ATOM   4289 C  C   . TYR   A 1 575 ? -11.099 -63.631 -27.924 1.00 25.44  ? 838  TYR   A C   1 
ATOM   4290 O  O   . TYR   A 1 575 ? -10.660 -64.126 -29.025 1.00 24.58  ? 838  TYR   A O   1 
ATOM   4291 C  CB  . TYR   A 1 575 ? -12.256 -65.113 -26.313 1.00 26.61  ? 838  TYR   A CB  1 
ATOM   4292 C  CG  . TYR   A 1 575 ? -13.491 -65.653 -25.625 1.00 28.42  ? 838  TYR   A CG  1 
ATOM   4293 C  CD1 . TYR   A 1 575 ? -14.169 -64.912 -24.677 1.00 24.30  ? 838  TYR   A CD1 1 
ATOM   4294 C  CD2 . TYR   A 1 575 ? -13.958 -66.933 -25.879 1.00 34.07  ? 838  TYR   A CD2 1 
ATOM   4295 C  CE1 . TYR   A 1 575 ? -15.263 -65.400 -23.993 1.00 25.91  ? 838  TYR   A CE1 1 
ATOM   4296 C  CE2 . TYR   A 1 575 ? -15.061 -67.440 -25.207 1.00 35.07  ? 838  TYR   A CE2 1 
ATOM   4297 C  CZ  . TYR   A 1 575 ? -15.737 -66.655 -24.288 1.00 29.85  ? 838  TYR   A CZ  1 
ATOM   4298 O  OH  . TYR   A 1 575 ? -16.821 -67.105 -23.612 1.00 34.20  ? 838  TYR   A OH  1 
ATOM   4299 N  N   . LEU   A 1 576 ? -10.397 -62.755 -27.188 0.28 23.91  ? 839  LEU   A N   1 
ATOM   4300 C  CA  . LEU   A 1 576 ? -8.953  -62.471 -27.421 0.28 24.02  ? 839  LEU   A CA  1 
ATOM   4301 C  C   . LEU   A 1 576 ? -8.200  -63.789 -27.213 0.28 23.97  ? 839  LEU   A C   1 
ATOM   4302 O  O   . LEU   A 1 576 ? -8.804  -64.720 -26.649 0.28 24.10  ? 839  LEU   A O   1 
ATOM   4303 C  CB  . LEU   A 1 576 ? -8.437  -61.398 -26.451 0.28 24.14  ? 839  LEU   A CB  1 
ATOM   4304 C  CG  . LEU   A 1 576 ? -9.184  -60.065 -26.432 0.28 23.01  ? 839  LEU   A CG  1 
ATOM   4305 C  CD1 . LEU   A 1 576 ? -8.762  -59.230 -25.235 0.28 23.36  ? 839  LEU   A CD1 1 
ATOM   4306 C  CD2 . LEU   A 1 576 ? -8.955  -59.282 -27.717 0.28 23.67  ? 839  LEU   A CD2 1 
ATOM   4307 N  N   . GLY   A 1 577 ? -6.945  -63.873 -27.656 0.28 24.52  ? 840  GLY   A N   1 
ATOM   4308 C  CA  . GLY   A 1 577 ? -6.056  -65.006 -27.339 0.28 24.13  ? 840  GLY   A CA  1 
ATOM   4309 C  C   . GLY   A 1 577 ? -5.978  -65.231 -25.834 0.28 23.67  ? 840  GLY   A C   1 
ATOM   4310 O  O   . GLY   A 1 577 ? -5.956  -64.231 -25.074 0.28 24.48  ? 840  GLY   A O   1 
ATOM   4311 N  N   . LYS   A 1 578 ? -5.956  -66.496 -25.401 0.28 22.93  ? 841  LYS   A N   1 
ATOM   4312 C  CA  . LYS   A 1 578 ? -5.834  -66.850 -23.961 0.28 23.62  ? 841  LYS   A CA  1 
ATOM   4313 C  C   . LYS   A 1 578 ? -4.709  -66.017 -23.338 0.28 22.76  ? 841  LYS   A C   1 
ATOM   4314 O  O   . LYS   A 1 578 ? -4.937  -65.427 -22.272 0.28 22.46  ? 841  LYS   A O   1 
ATOM   4315 C  CB  . LYS   A 1 578 ? -5.543  -68.338 -23.762 0.28 23.57  ? 841  LYS   A CB  1 
ATOM   4316 C  CG  . LYS   A 1 578 ? -5.212  -68.730 -22.325 0.28 24.19  ? 841  LYS   A CG  1 
ATOM   4317 C  CD  . LYS   A 1 578 ? -5.380  -70.220 -22.046 0.28 25.35  ? 841  LYS   A CD  1 
ATOM   4318 C  CE  . LYS   A 1 578 ? -5.319  -70.572 -20.572 0.28 24.95  ? 841  LYS   A CE  1 
ATOM   4319 N  NZ  . LYS   A 1 578 ? -5.630  -72.001 -20.341 0.28 24.95  ? 841  LYS   A NZ  1 
ATOM   4320 N  N   . ARG   A 1 579 ? -3.548  -65.961 -23.995 1.00 22.27  ? 842  ARG   A N   1 
ATOM   4321 C  CA  . ARG   A 1 579 ? -2.370  -65.267 -23.453 1.00 24.03  ? 842  ARG   A CA  1 
ATOM   4322 C  C   . ARG   A 1 579 ? -2.658  -63.750 -23.400 1.00 21.22  ? 842  ARG   A C   1 
ATOM   4323 O  O   . ARG   A 1 579 ? -2.320  -63.100 -22.402 1.00 21.96  ? 842  ARG   A O   1 
ATOM   4324 C  CB  . ARG   A 1 579 ? -1.087  -65.617 -24.222 1.00 23.35  ? 842  ARG   A CB  1 
ATOM   4325 C  CG  . ARG   A 1 579 ? 0.164   -65.126 -23.507 1.00 25.83  ? 842  ARG   A CG  1 
ATOM   4326 C  CD  . ARG   A 1 579 ? 1.453   -65.375 -24.325 1.00 30.04  ? 842  ARG   A CD  1 
ATOM   4327 N  NE  . ARG   A 1 579 ? 1.605   -66.814 -24.437 1.00 30.58  ? 842  ARG   A NE  1 
ATOM   4328 C  CZ  . ARG   A 1 579 ? 2.024   -67.616 -23.490 1.00 31.60  ? 842  ARG   A CZ  1 
ATOM   4329 N  NH1 . ARG   A 1 579 ? 2.030   -68.910 -23.732 1.00 41.75  ? 842  ARG   A NH1 1 
ATOM   4330 N  NH2 . ARG   A 1 579 ? 2.414   -67.165 -22.315 1.00 35.07  ? 842  ARG   A NH2 1 
ATOM   4331 N  N   . GLU   A 1 580 ? -3.292  -63.212 -24.440 0.28 21.30  ? 843  GLU   A N   1 
ATOM   4332 C  CA  . GLU   A 1 580 ? -3.629  -61.763 -24.533 0.28 21.60  ? 843  GLU   A CA  1 
ATOM   4333 C  C   . GLU   A 1 580 ? -4.719  -61.410 -23.499 0.28 21.15  ? 843  GLU   A C   1 
ATOM   4334 O  O   . GLU   A 1 580 ? -4.766  -60.248 -23.094 0.28 20.86  ? 843  GLU   A O   1 
ATOM   4335 C  CB  . GLU   A 1 580 ? -4.020  -61.417 -25.972 0.28 21.28  ? 843  GLU   A CB  1 
ATOM   4336 C  CG  . GLU   A 1 580 ? -2.859  -61.510 -26.949 0.28 21.86  ? 843  GLU   A CG  1 
ATOM   4337 C  CD  . GLU   A 1 580 ? -3.241  -61.544 -28.421 0.28 22.49  ? 843  GLU   A CD  1 
ATOM   4338 O  OE1 . GLU   A 1 580 ? -4.096  -62.375 -28.784 0.28 22.81  ? 843  GLU   A OE1 1 
ATOM   4339 O  OE2 . GLU   A 1 580 ? -2.685  -60.741 -29.207 0.28 22.72  ? 843  GLU   A OE2 1 
ATOM   4340 N  N   . ASP   A 1 581 ? -5.548  -62.376 -23.085 1.00 21.57  ? 844  ASP   A N   1 
ATOM   4341 C  CA  . ASP   A 1 581 ? -6.595  -62.184 -22.042 1.00 21.92  ? 844  ASP   A CA  1 
ATOM   4342 C  C   . ASP   A 1 581 ? -5.910  -62.100 -20.680 1.00 22.60  ? 844  ASP   A C   1 
ATOM   4343 O  O   . ASP   A 1 581 ? -6.217  -61.151 -19.901 1.00 19.38  ? 844  ASP   A O   1 
ATOM   4344 C  CB  . ASP   A 1 581 ? -7.626  -63.305 -22.134 1.00 23.40  ? 844  ASP   A CB  1 
ATOM   4345 C  CG  . ASP   A 1 581 ? -9.060  -62.993 -21.681 1.00 22.11  ? 844  ASP   A CG  1 
ATOM   4346 O  OD1 . ASP   A 1 581 ? -9.295  -61.957 -21.032 1.00 20.14  ? 844  ASP   A OD1 1 
ATOM   4347 O  OD2 . ASP   A 1 581 ? -9.958  -63.830 -21.995 1.00 21.77  ? 844  ASP   A OD2 1 
ATOM   4348 N  N   . GLN   A 1 582 ? -4.924  -62.960 -20.448 1.00 21.42  ? 845  GLN   A N   1 
ATOM   4349 C  CA  . GLN   A 1 582 ? -4.105  -62.932 -19.218 1.00 20.21  ? 845  GLN   A CA  1 
ATOM   4350 C  C   . GLN   A 1 582 ? -3.319  -61.638 -19.146 1.00 21.72  ? 845  GLN   A C   1 
ATOM   4351 O  O   . GLN   A 1 582 ? -3.361  -61.002 -18.104 1.00 20.07  ? 845  GLN   A O   1 
ATOM   4352 C  CB  . GLN   A 1 582 ? -3.158  -64.161 -19.127 1.00 23.57  ? 845  GLN   A CB  1 
ATOM   4353 C  CG  . GLN   A 1 582 ? -3.879  -65.466 -18.993 1.00 25.32  ? 845  GLN   A CG  1 
ATOM   4354 C  CD  . GLN   A 1 582 ? -2.935  -66.658 -19.129 1.00 32.42  ? 845  GLN   A CD  1 
ATOM   4355 O  OE1 . GLN   A 1 582 ? -1.932  -66.573 -19.798 1.00 30.34  ? 845  GLN   A OE1 1 
ATOM   4356 N  NE2 . GLN   A 1 582 ? -3.228  -67.769 -18.471 1.00 29.34  ? 845  GLN   A NE2 1 
ATOM   4357 N  N   . TRP   A 1 583 ? -2.662  -61.217 -20.230 1.00 18.85  ? 846  TRP   A N   1 
ATOM   4358 C  CA  . TRP   A 1 583 ? -1.934  -59.925 -20.267 1.00 17.79  ? 846  TRP   A CA  1 
ATOM   4359 C  C   . TRP   A 1 583 ? -2.853  -58.770 -19.824 1.00 22.63  ? 846  TRP   A C   1 
ATOM   4360 O  O   . TRP   A 1 583 ? -2.366  -57.851 -19.077 1.00 21.12  ? 846  TRP   A O   1 
ATOM   4361 C  CB  . TRP   A 1 583 ? -1.352  -59.649 -21.657 1.00 18.87  ? 846  TRP   A CB  1 
ATOM   4362 C  CG  . TRP   A 1 583 ? -0.176  -60.522 -22.024 1.00 20.72  ? 846  TRP   A CG  1 
ATOM   4363 C  CD1 . TRP   A 1 583 ? 0.636   -61.228 -21.184 1.00 22.18  ? 846  TRP   A CD1 1 
ATOM   4364 C  CD2 . TRP   A 1 583 ? 0.303   -60.802 -23.348 1.00 21.84  ? 846  TRP   A CD2 1 
ATOM   4365 N  NE1 . TRP   A 1 583 ? 1.589   -61.917 -21.885 1.00 23.49  ? 846  TRP   A NE1 1 
ATOM   4366 C  CE2 . TRP   A 1 583 ? 1.430   -61.640 -23.216 1.00 22.75  ? 846  TRP   A CE2 1 
ATOM   4367 C  CE3 . TRP   A 1 583 ? -0.074  -60.379 -24.615 1.00 25.21  ? 846  TRP   A CE3 1 
ATOM   4368 C  CZ2 . TRP   A 1 583 ? 2.153   -62.067 -24.317 1.00 27.77  ? 846  TRP   A CZ2 1 
ATOM   4369 C  CZ3 . TRP   A 1 583 ? 0.646   -60.804 -25.706 1.00 29.19  ? 846  TRP   A CZ3 1 
ATOM   4370 C  CH2 . TRP   A 1 583 ? 1.684   -61.707 -25.564 1.00 27.17  ? 846  TRP   A CH2 1 
ATOM   4371 N  N   . CYS   A 1 584 ? -4.129  -58.756 -20.268 1.00 19.76  ? 847  CYS   A N   1 
ATOM   4372 C  CA  . CYS   A 1 584 ? -5.076  -57.659 -19.951 1.00 19.42  ? 847  CYS   A CA  1 
ATOM   4373 C  C   . CYS   A 1 584 ? -5.834  -57.937 -18.643 1.00 21.24  ? 847  CYS   A C   1 
ATOM   4374 O  O   . CYS   A 1 584 ? -6.849  -57.276 -18.426 1.00 23.81  ? 847  CYS   A O   1 
ATOM   4375 C  CB  . CYS   A 1 584 ? -5.981  -57.419 -21.125 1.00 20.09  ? 847  CYS   A CB  1 
ATOM   4376 S  SG  . CYS   A 1 584 ? -5.029  -56.652 -22.460 1.00 24.14  ? 847  CYS   A SG  1 
ATOM   4377 N  N   . GLY   A 1 585 ? -5.361  -58.900 -17.831 1.00 23.05  ? 848  GLY   A N   1 
ATOM   4378 C  CA  . GLY   A 1 585 ? -5.752  -59.079 -16.407 1.00 23.07  ? 848  GLY   A CA  1 
ATOM   4379 C  C   . GLY   A 1 585 ? -6.616  -60.306 -16.122 1.00 23.86  ? 848  GLY   A C   1 
ATOM   4380 O  O   . GLY   A 1 585 ? -7.097  -60.413 -14.998 1.00 26.41  ? 848  GLY   A O   1 
ATOM   4381 N  N   . SER   A 1 586 ? -6.932  -61.173 -17.093 1.00 23.72  ? 849  SER   A N   1 
ATOM   4382 C  CA  . SER   A 1 586 ? -7.742  -62.403 -16.848 1.00 24.34  ? 849  SER   A CA  1 
ATOM   4383 C  C   . SER   A 1 586 ? -7.121  -63.256 -15.730 1.00 24.58  ? 849  SER   A C   1 
ATOM   4384 O  O   . SER   A 1 586 ? -5.911  -63.389 -15.695 1.00 20.76  ? 849  SER   A O   1 
ATOM   4385 C  CB  . SER   A 1 586 ? -7.859  -63.248 -18.066 1.00 20.24  ? 849  SER   A CB  1 
ATOM   4386 O  OG  . SER   A 1 586 ? -8.811  -64.263 -17.887 1.00 21.49  ? 849  SER   A OG  1 
ATOM   4387 N  N   . LEU   A 1 587 ? -7.988  -63.919 -14.977 1.00 23.99  ? 850  LEU   A N   1 
ATOM   4388 C  CA  . LEU   A 1 587 ? -7.619  -64.925 -13.956 1.00 26.90  ? 850  LEU   A CA  1 
ATOM   4389 C  C   . LEU   A 1 587 ? -7.682  -66.313 -14.566 1.00 25.69  ? 850  LEU   A C   1 
ATOM   4390 O  O   . LEU   A 1 587 ? -7.497  -67.234 -13.800 1.00 29.02  ? 850  LEU   A O   1 
ATOM   4391 C  CB  . LEU   A 1 587 ? -8.557  -64.829 -12.734 1.00 28.45  ? 850  LEU   A CB  1 
ATOM   4392 C  CG  . LEU   A 1 587 ? -8.572  -63.517 -11.963 1.00 31.31  ? 850  LEU   A CG  1 
ATOM   4393 C  CD1 . LEU   A 1 587 ? -9.217  -63.694 -10.595 1.00 29.42  ? 850  LEU   A CD1 1 
ATOM   4394 C  CD2 . LEU   A 1 587 ? -7.176  -62.897 -11.837 1.00 32.18  ? 850  LEU   A CD2 1 
ATOM   4395 N  N   . ILE   A 1 588 ? -7.996  -66.461 -15.863 1.00 27.98  ? 851  ILE   A N   1 
ATOM   4396 C  CA  . ILE   A 1 588 ? -8.058  -67.798 -16.521 1.00 30.81  ? 851  ILE   A CA  1 
ATOM   4397 C  C   . ILE   A 1 588 ? -6.710  -68.511 -16.241 1.00 32.67  ? 851  ILE   A C   1 
ATOM   4398 O  O   . ILE   A 1 588 ? -5.639  -67.879 -16.380 1.00 24.89  ? 851  ILE   A O   1 
ATOM   4399 C  CB  . ILE   A 1 588 ? -8.381  -67.634 -18.021 1.00 36.68  ? 851  ILE   A CB  1 
ATOM   4400 C  CG1 . ILE   A 1 588 ? -8.791  -68.910 -18.744 1.00 39.19  ? 851  ILE   A CG1 1 
ATOM   4401 C  CG2 . ILE   A 1 588 ? -7.227  -66.951 -18.762 1.00 36.98  ? 851  ILE   A CG2 1 
ATOM   4402 C  CD1 . ILE   A 1 588 ? -10.155 -69.481 -18.373 1.00 43.65  ? 851  ILE   A CD1 1 
ATOM   4403 N  N   . GLY   A 1 589 ? -6.740  -69.769 -15.781 1.00 32.41  ? 852  GLY   A N   1 
ATOM   4404 C  CA  . GLY   A 1 589 ? -5.516  -70.507 -15.412 1.00 32.65  ? 852  GLY   A CA  1 
ATOM   4405 C  C   . GLY   A 1 589 ? -5.353  -70.601 -13.913 1.00 35.48  ? 852  GLY   A C   1 
ATOM   4406 O  O   . GLY   A 1 589 ? -4.718  -71.511 -13.485 1.00 40.57  ? 852  GLY   A O   1 
ATOM   4407 N  N   . LEU   A 1 590 ? -5.986  -69.749 -13.121 1.00 31.40  ? 853  LEU   A N   1 
ATOM   4408 C  CA  . LEU   A 1 590 ? -5.906  -69.851 -11.646 1.00 32.35  ? 853  LEU   A CA  1 
ATOM   4409 C  C   . LEU   A 1 590 ? -6.975  -70.814 -11.118 1.00 35.59  ? 853  LEU   A C   1 
ATOM   4410 O  O   . LEU   A 1 590 ? -8.121  -70.863 -11.639 1.00 31.68  ? 853  LEU   A O   1 
ATOM   4411 C  CB  . LEU   A 1 590 ? -6.103  -68.511 -10.949 1.00 33.70  ? 853  LEU   A CB  1 
ATOM   4412 C  CG  . LEU   A 1 590 ? -5.106  -67.390 -11.230 1.00 39.25  ? 853  LEU   A CG  1 
ATOM   4413 C  CD1 . LEU   A 1 590 ? -5.410  -66.251 -10.276 1.00 40.57  ? 853  LEU   A CD1 1 
ATOM   4414 C  CD2 . LEU   A 1 590 ? -3.663  -67.859 -11.079 1.00 40.00  ? 853  LEU   A CD2 1 
ATOM   4415 N  N   . THR   A 1 591 ? -6.610  -71.499 -10.050 1.00 34.51  ? 854  THR   A N   1 
ATOM   4416 C  CA  . THR   A 1 591 ? -7.480  -72.423 -9.292  1.00 38.18  ? 854  THR   A CA  1 
ATOM   4417 C  C   . THR   A 1 591 ? -8.699  -71.676 -8.741  1.00 31.12  ? 854  THR   A C   1 
ATOM   4418 O  O   . THR   A 1 591 ? -9.778  -72.253 -8.781  1.00 32.32  ? 854  THR   A O   1 
ATOM   4419 C  CB  . THR   A 1 591 ? -6.639  -73.028 -8.150  1.00 40.98  ? 854  THR   A CB  1 
ATOM   4420 O  OG1 . THR   A 1 591 ? -5.597  -73.709 -8.827  1.00 44.56  ? 854  THR   A OG1 1 
ATOM   4421 C  CG2 . THR   A 1 591 ? -7.376  -73.999 -7.266  1.00 44.87  ? 854  THR   A CG2 1 
ATOM   4422 N  N   . SER   A 1 592 ? -8.539  -70.494 -8.154  1.00 29.76  ? 855  SER   A N   1 
ATOM   4423 C  CA  . SER   A 1 592 ? -9.693  -69.676 -7.677  1.00 28.05  ? 855  SER   A CA  1 
ATOM   4424 C  C   . SER   A 1 592 ? -10.716 -69.484 -8.830  1.00 29.04  ? 855  SER   A C   1 
ATOM   4425 O  O   . SER   A 1 592 ? -11.939 -69.619 -8.595  1.00 28.36  ? 855  SER   A O   1 
ATOM   4426 C  CB  . SER   A 1 592 ? -9.291  -68.369 -7.053  1.00 30.30  ? 855  SER   A CB  1 
ATOM   4427 O  OG  . SER   A 1 592 ? -8.516  -67.557 -7.935  1.00 35.22  ? 855  SER   A OG  1 
ATOM   4428 N  N   . ARG   A 1 593 ? -10.243 -69.237 -10.044 1.00 31.24  ? 856  ARG   A N   1 
ATOM   4429 C  CA  . ARG   A 1 593 ? -11.116 -68.905 -11.188 1.00 28.37  ? 856  ARG   A CA  1 
ATOM   4430 C  C   . ARG   A 1 593 ? -11.820 -70.184 -11.633 1.00 28.85  ? 856  ARG   A C   1 
ATOM   4431 O  O   . ARG   A 1 593 ? -12.997 -70.094 -12.017 1.00 27.17  ? 856  ARG   A O   1 
ATOM   4432 C  CB  . ARG   A 1 593 ? -10.278 -68.258 -12.287 1.00 27.58  ? 856  ARG   A CB  1 
ATOM   4433 C  CG  . ARG   A 1 593 ? -11.065 -67.616 -13.421 1.00 28.30  ? 856  ARG   A CG  1 
ATOM   4434 C  CD  . ARG   A 1 593 ? -11.583 -68.583 -14.460 1.00 28.59  ? 856  ARG   A CD  1 
ATOM   4435 N  NE  . ARG   A 1 593 ? -12.069 -67.805 -15.597 1.00 26.92  ? 856  ARG   A NE  1 
ATOM   4436 C  CZ  . ARG   A 1 593 ? -12.876 -68.293 -16.526 1.00 29.04  ? 856  ARG   A CZ  1 
ATOM   4437 N  NH1 . ARG   A 1 593 ? -13.204 -69.571 -16.479 1.00 27.39  ? 856  ARG   A NH1 1 
ATOM   4438 N  NH2 . ARG   A 1 593 ? -13.358 -67.524 -17.491 1.00 27.29  ? 856  ARG   A NH2 1 
ATOM   4439 N  N   . ALA   A 1 594 ? -11.090 -71.289 -11.785 1.00 27.31  ? 857  ALA   A N   1 
ATOM   4440 C  CA  . ALA   A 1 594 ? -11.673 -72.589 -12.216 1.00 29.59  ? 857  ALA   A CA  1 
ATOM   4441 C  C   . ALA   A 1 594 ? -12.801 -72.992 -11.238 1.00 26.55  ? 857  ALA   A C   1 
ATOM   4442 O  O   . ALA   A 1 594 ? -13.853 -73.475 -11.683 1.00 28.70  ? 857  ALA   A O   1 
ATOM   4443 C  CB  . ALA   A 1 594 ? -10.605 -73.663 -12.309 1.00 31.45  ? 857  ALA   A CB  1 
ATOM   4444 N  N   . THR   A 1 595 ? -12.595 -72.836 -9.949  1.00 26.30  ? 858  THR   A N   1 
ATOM   4445 C  CA  . THR   A 1 595 ? -13.610 -73.229 -8.958  1.00 31.25  ? 858  THR   A CA  1 
ATOM   4446 C  C   . THR   A 1 595 ? -14.849 -72.324 -9.085  1.00 32.34  ? 858  THR   A C   1 
ATOM   4447 O  O   . THR   A 1 595 ? -16.003 -72.803 -9.025  1.00 27.64  ? 858  THR   A O   1 
ATOM   4448 C  CB  . THR   A 1 595 ? -13.045 -73.078 -7.554  1.00 35.17  ? 858  THR   A CB  1 
ATOM   4449 O  OG1 . THR   A 1 595 ? -11.934 -73.977 -7.511  1.00 42.62  ? 858  THR   A OG1 1 
ATOM   4450 C  CG2 . THR   A 1 595 ? -14.108 -73.375 -6.523  1.00 37.60  ? 858  THR   A CG2 1 
ATOM   4451 N  N   . TRP   A 1 596 ? -14.621 -71.025 -9.211  1.00 26.69  ? 859  TRP   A N   1 
ATOM   4452 C  CA  . TRP   A 1 596 ? -15.731 -70.080 -9.496  1.00 25.51  ? 859  TRP   A CA  1 
ATOM   4453 C  C   . TRP   A 1 596 ? -16.513 -70.515 -10.744 1.00 22.84  ? 859  TRP   A C   1 
ATOM   4454 O  O   . TRP   A 1 596 ? -17.757 -70.546 -10.677 1.00 25.05  ? 859  TRP   A O   1 
ATOM   4455 C  CB  . TRP   A 1 596 ? -15.132 -68.685 -9.637  1.00 25.72  ? 859  TRP   A CB  1 
ATOM   4456 C  CG  . TRP   A 1 596 ? -16.028 -67.596 -10.152 1.00 24.04  ? 859  TRP   A CG  1 
ATOM   4457 C  CD1 . TRP   A 1 596 ? -17.041 -66.987 -9.484  1.00 23.01  ? 859  TRP   A CD1 1 
ATOM   4458 C  CD2 . TRP   A 1 596 ? -15.871 -66.900 -11.400 1.00 26.09  ? 859  TRP   A CD2 1 
ATOM   4459 N  NE1 . TRP   A 1 596 ? -17.538 -65.954 -10.220 1.00 23.66  ? 859  TRP   A NE1 1 
ATOM   4460 C  CE2 . TRP   A 1 596 ? -16.877 -65.905 -11.423 1.00 25.09  ? 859  TRP   A CE2 1 
ATOM   4461 C  CE3 . TRP   A 1 596 ? -15.020 -67.055 -12.516 1.00 25.83  ? 859  TRP   A CE3 1 
ATOM   4462 C  CZ2 . TRP   A 1 596 ? -16.997 -65.017 -12.482 1.00 23.11  ? 859  TRP   A CZ2 1 
ATOM   4463 C  CZ3 . TRP   A 1 596 ? -15.137 -66.168 -13.570 1.00 25.59  ? 859  TRP   A CZ3 1 
ATOM   4464 C  CH2 . TRP   A 1 596 ? -16.105 -65.141 -13.520 1.00 26.13  ? 859  TRP   A CH2 1 
ATOM   4465 N  N   . ALA   A 1 597 ? -15.861 -70.724 -11.880 1.00 22.52  ? 860  ALA   A N   1 
ATOM   4466 C  CA  . ALA   A 1 597 ? -16.545 -71.045 -13.155 1.00 24.89  ? 860  ALA   A CA  1 
ATOM   4467 C  C   . ALA   A 1 597 ? -17.342 -72.347 -13.015 1.00 28.62  ? 860  ALA   A C   1 
ATOM   4468 O  O   . ALA   A 1 597 ? -18.536 -72.400 -13.410 1.00 28.38  ? 860  ALA   A O   1 
ATOM   4469 C  CB  . ALA   A 1 597 ? -15.535 -71.168 -14.272 1.00 24.47  ? 860  ALA   A CB  1 
ATOM   4470 N  N   . LYS   A 1 598 ? -16.716 -73.351 -12.409 1.00 31.19  ? 861  LYS   A N   1 
ATOM   4471 C  CA  . LYS   A 1 598 ? -17.333 -74.690 -12.245 1.00 33.95  ? 861  LYS   A CA  1 
ATOM   4472 C  C   . LYS   A 1 598 ? -18.581 -74.608 -11.359 1.00 29.87  ? 861  LYS   A C   1 
ATOM   4473 O  O   . LYS   A 1 598 ? -19.562 -75.263 -11.684 1.00 33.47  ? 861  LYS   A O   1 
ATOM   4474 C  CB  . LYS   A 1 598 ? -16.316 -75.634 -11.601 1.00 41.21  ? 861  LYS   A CB  1 
ATOM   4475 C  CG  . LYS   A 1 598 ? -16.749 -77.088 -11.459 1.00 53.67  ? 861  LYS   A CG  1 
ATOM   4476 C  CD  . LYS   A 1 598 ? -15.716 -77.945 -10.711 1.00 64.72  ? 861  LYS   A CD  1 
ATOM   4477 C  CE  . LYS   A 1 598 ? -15.726 -79.388 -11.174 1.00 78.47  ? 861  LYS   A CE  1 
ATOM   4478 N  NZ  . LYS   A 1 598 ? -17.113 -79.884 -11.391 1.00 71.17  ? 861  LYS   A NZ  1 
ATOM   4479 N  N   . ASN   A 1 599 ? -18.516 -73.886 -10.248 1.00 31.17  ? 862  ASN   A N   1 
ATOM   4480 C  CA  . ASN   A 1 599 ? -19.589 -73.780 -9.232  1.00 30.03  ? 862  ASN   A CA  1 
ATOM   4481 C  C   . ASN   A 1 599 ? -20.460 -72.527 -9.466  1.00 26.38  ? 862  ASN   A C   1 
ATOM   4482 O  O   . ASN   A 1 599 ? -21.161 -72.123 -8.542  1.00 26.52  ? 862  ASN   A O   1 
ATOM   4483 C  CB  . ASN   A 1 599 ? -19.007 -73.777 -7.814  1.00 30.21  ? 862  ASN   A CB  1 
ATOM   4484 C  CG  . ASN   A 1 599 ? -18.236 -75.033 -7.460  1.00 38.54  ? 862  ASN   A CG  1 
ATOM   4485 O  OD1 . ASN   A 1 599 ? -18.639 -76.124 -7.787  1.00 37.48  ? 862  ASN   A OD1 1 
ATOM   4486 N  ND2 . ASN   A 1 599 ? -17.159 -74.880 -6.732  1.00 45.13  ? 862  ASN   A ND2 1 
ATOM   4487 N  N   . ILE   A 1 600 ? -20.519 -71.958 -10.662 1.00 26.53  ? 863  ILE   A N   1 
ATOM   4488 C  CA  . ILE   A 1 600 ? -21.219 -70.636 -10.863 1.00 25.03  ? 863  ILE   A CA  1 
ATOM   4489 C  C   . ILE   A 1 600 ? -22.733 -70.727 -10.528 1.00 28.38  ? 863  ILE   A C   1 
ATOM   4490 O  O   . ILE   A 1 600 ? -23.291 -69.731 -10.032 1.00 23.30  ? 863  ILE   A O   1 
ATOM   4491 C  CB  . ILE   A 1 600 ? -20.921 -70.052 -12.249 1.00 23.82  ? 863  ILE   A CB  1 
ATOM   4492 C  CG1 . ILE   A 1 600 ? -21.181 -68.541 -12.324 1.00 27.25  ? 863  ILE   A CG1 1 
ATOM   4493 C  CG2 . ILE   A 1 600 ? -21.621 -70.785 -13.405 1.00 27.31  ? 863  ILE   A CG2 1 
ATOM   4494 C  CD1 . ILE   A 1 600 ? -20.292 -67.757 -11.443 1.00 25.45  ? 863  ILE   A CD1 1 
ATOM   4495 N  N   A GLN   A 1 601 ? -23.379 -71.882 -10.765 0.25 25.85  ? 864  GLN   A N   1 
ATOM   4496 N  N   B GLN   A 1 601 ? -23.380 -71.882 -10.762 0.25 26.52  ? 864  GLN   A N   1 
ATOM   4497 C  CA  A GLN   A 1 601 ? -24.837 -72.045 -10.505 0.25 27.06  ? 864  GLN   A CA  1 
ATOM   4498 C  CA  B GLN   A 1 601 ? -24.842 -72.044 -10.512 0.25 28.22  ? 864  GLN   A CA  1 
ATOM   4499 C  C   A GLN   A 1 601 ? -25.120 -71.893 -8.999  0.25 27.39  ? 864  GLN   A C   1 
ATOM   4500 C  C   B GLN   A 1 601 ? -25.126 -71.908 -9.003  0.25 28.07  ? 864  GLN   A C   1 
ATOM   4501 O  O   A GLN   A 1 601 ? -26.179 -71.327 -8.643  0.25 28.09  ? 864  GLN   A O   1 
ATOM   4502 O  O   B GLN   A 1 601 ? -26.194 -71.360 -8.647  0.25 28.85  ? 864  GLN   A O   1 
ATOM   4503 C  CB  A GLN   A 1 601 ? -25.360 -73.362 -11.079 0.25 28.39  ? 864  GLN   A CB  1 
ATOM   4504 C  CB  B GLN   A 1 601 ? -25.361 -73.345 -11.131 0.25 30.42  ? 864  GLN   A CB  1 
ATOM   4505 C  CG  A GLN   A 1 601 ? -25.316 -73.418 -12.601 0.25 27.03  ? 864  GLN   A CG  1 
ATOM   4506 C  CG  B GLN   A 1 601 ? -26.882 -73.422 -11.251 0.25 30.32  ? 864  GLN   A CG  1 
ATOM   4507 C  CD  A GLN   A 1 601 ? -26.307 -72.509 -13.290 0.25 28.29  ? 864  GLN   A CD  1 
ATOM   4508 C  CD  B GLN   A 1 601 ? -27.541 -72.184 -11.816 0.25 31.02  ? 864  GLN   A CD  1 
ATOM   4509 O  OE1 A GLN   A 1 601 ? -27.270 -72.027 -12.695 0.25 29.35  ? 864  GLN   A OE1 1 
ATOM   4510 O  OE1 B GLN   A 1 601 ? -27.301 -71.782 -12.953 0.25 30.88  ? 864  GLN   A OE1 1 
ATOM   4511 N  NE2 A GLN   A 1 601 ? -26.087 -72.284 -14.579 0.25 28.38  ? 864  GLN   A NE2 1 
ATOM   4512 N  NE2 B GLN   A 1 601 ? -28.409 -71.581 -11.020 0.25 29.64  ? 864  GLN   A NE2 1 
ATOM   4513 N  N   . THR   A 1 602 ? -24.192 -72.315 -8.146  1.00 26.03  ? 865  THR   A N   1 
ATOM   4514 C  CA  . THR   A 1 602 ? -24.291 -72.083 -6.686  1.00 29.56  ? 865  THR   A CA  1 
ATOM   4515 C  C   . THR   A 1 602 ? -24.284 -70.590 -6.345  1.00 27.67  ? 865  THR   A C   1 
ATOM   4516 O  O   . THR   A 1 602 ? -25.013 -70.175 -5.424  1.00 27.88  ? 865  THR   A O   1 
ATOM   4517 C  CB  . THR   A 1 602 ? -23.203 -72.881 -5.976  1.00 31.54  ? 865  THR   A CB  1 
ATOM   4518 O  OG1 . THR   A 1 602 ? -23.459 -74.221 -6.437  1.00 36.20  ? 865  THR   A OG1 1 
ATOM   4519 C  CG2 . THR   A 1 602 ? -23.315 -72.776 -4.484  1.00 34.70  ? 865  THR   A CG2 1 
ATOM   4520 N  N   . ALA   A 1 603 ? -23.469 -69.786 -7.013  1.00 28.50  ? 866  ALA   A N   1 
ATOM   4521 C  CA  . ALA   A 1 603 ? -23.362 -68.340 -6.717  1.00 23.91  ? 866  ALA   A CA  1 
ATOM   4522 C  C   . ALA   A 1 603 ? -24.636 -67.688 -7.190  1.00 23.27  ? 866  ALA   A C   1 
ATOM   4523 O  O   . ALA   A 1 603 ? -25.214 -66.896 -6.446  1.00 25.74  ? 866  ALA   A O   1 
ATOM   4524 C  CB  . ALA   A 1 603 ? -22.186 -67.761 -7.441  1.00 25.13  ? 866  ALA   A CB  1 
ATOM   4525 N  N   . ILE   A 1 604 ? -25.070 -68.039 -8.401  1.00 25.74  ? 867  ILE   A N   1 
ATOM   4526 C  CA  . ILE   A 1 604 ? -26.310 -67.482 -9.030  1.00 25.30  ? 867  ILE   A CA  1 
ATOM   4527 C  C   . ILE   A 1 604 ? -27.486 -67.767 -8.075  1.00 25.44  ? 867  ILE   A C   1 
ATOM   4528 O  O   . ILE   A 1 604 ? -28.243 -66.874 -7.749  1.00 24.00  ? 867  ILE   A O   1 
ATOM   4529 C  CB  . ILE   A 1 604 ? -26.503 -68.100 -10.427 1.00 24.81  ? 867  ILE   A CB  1 
ATOM   4530 C  CG1 . ILE   A 1 604 ? -25.442 -67.568 -11.389 1.00 24.49  ? 867  ILE   A CG1 1 
ATOM   4531 C  CG2 . ILE   A 1 604 ? -27.918 -67.867 -10.967 1.00 25.32  ? 867  ILE   A CG2 1 
ATOM   4532 C  CD1 . ILE   A 1 604 ? -25.417 -68.263 -12.716 1.00 30.31  ? 867  ILE   A CD1 1 
ATOM   4533 N  N   . ASN   A 1 605 ? -27.549 -68.983 -7.554  1.00 28.40  ? 868  ASN   A N   1 
ATOM   4534 C  CA  . ASN   A 1 605 ? -28.651 -69.436 -6.666  1.00 30.02  ? 868  ASN   A CA  1 
ATOM   4535 C  C   . ASN   A 1 605 ? -28.566 -68.699 -5.323  1.00 27.00  ? 868  ASN   A C   1 
ATOM   4536 O  O   . ASN   A 1 605 ? -29.631 -68.436 -4.760  1.00 25.68  ? 868  ASN   A O   1 
ATOM   4537 C  CB  . ASN   A 1 605 ? -28.640 -70.959 -6.502  1.00 29.23  ? 868  ASN   A CB  1 
ATOM   4538 C  CG  . ASN   A 1 605 ? -29.164 -71.673 -7.742  1.00 33.96  ? 868  ASN   A CG  1 
ATOM   4539 O  OD1 . ASN   A 1 605 ? -29.851 -71.121 -8.608  1.00 39.22  ? 868  ASN   A OD1 1 
ATOM   4540 N  ND2 . ASN   A 1 605 ? -28.852 -72.937 -7.843  1.00 37.96  ? 868  ASN   A ND2 1 
ATOM   4541 N  N   . GLN   A 1 606 ? -27.372 -68.372 -4.836  1.00 29.23  ? 869  GLN   A N   1 
ATOM   4542 C  CA  . GLN   A 1 606 ? -27.238 -67.574 -3.601  1.00 26.94  ? 869  GLN   A CA  1 
ATOM   4543 C  C   . GLN   A 1 606 ? -27.941 -66.223 -3.794  1.00 26.00  ? 869  GLN   A C   1 
ATOM   4544 O  O   . GLN   A 1 606 ? -28.706 -65.776 -2.887  1.00 27.24  ? 869  GLN   A O   1 
ATOM   4545 C  CB  . GLN   A 1 606 ? -25.783 -67.376 -3.163  1.00 29.58  ? 869  GLN   A CB  1 
ATOM   4546 C  CG  . GLN   A 1 606 ? -25.667 -66.626 -1.834  1.00 33.47  ? 869  GLN   A CG  1 
ATOM   4547 C  CD  . GLN   A 1 606 ? -24.260 -66.263 -1.395  1.00 39.67  ? 869  GLN   A CD  1 
ATOM   4548 O  OE1 . GLN   A 1 606 ? -23.340 -66.103 -2.211  1.00 35.78  ? 869  GLN   A OE1 1 
ATOM   4549 N  NE2 . GLN   A 1 606 ? -24.081 -66.119 -0.089  1.00 33.47  ? 869  GLN   A NE2 1 
ATOM   4550 N  N   . VAL   A 1 607 ? -27.640 -65.546 -4.886  1.00 23.46  ? 870  VAL   A N   1 
ATOM   4551 C  CA  . VAL   A 1 607 ? -28.226 -64.218 -5.185  1.00 24.24  ? 870  VAL   A CA  1 
ATOM   4552 C  C   . VAL   A 1 607 ? -29.749 -64.342 -5.465  1.00 23.32  ? 870  VAL   A C   1 
ATOM   4553 O  O   . VAL   A 1 607 ? -30.525 -63.550 -4.900  1.00 24.56  ? 870  VAL   A O   1 
ATOM   4554 C  CB  . VAL   A 1 607 ? -27.464 -63.558 -6.339  1.00 25.90  ? 870  VAL   A CB  1 
ATOM   4555 C  CG1 . VAL   A 1 607 ? -28.187 -62.298 -6.760  1.00 23.01  ? 870  VAL   A CG1 1 
ATOM   4556 C  CG2 . VAL   A 1 607 ? -26.008 -63.284 -5.930  1.00 26.57  ? 870  VAL   A CG2 1 
ATOM   4557 N  N   . ARG   A 1 608 ? -30.191 -65.354 -6.213  1.00 25.31  ? 871  ARG   A N   1 
ATOM   4558 C  CA  . ARG   A 1 608 ? -31.649 -65.564 -6.422  1.00 29.53  ? 871  ARG   A CA  1 
ATOM   4559 C  C   . ARG   A 1 608 ? -32.388 -65.763 -5.086  1.00 27.22  ? 871  ARG   A C   1 
ATOM   4560 O  O   . ARG   A 1 608 ? -33.484 -65.191 -4.917  1.00 30.80  ? 871  ARG   A O   1 
ATOM   4561 C  CB  . ARG   A 1 608 ? -31.865 -66.776 -7.314  1.00 25.84  ? 871  ARG   A CB  1 
ATOM   4562 C  CG  . ARG   A 1 608 ? -31.460 -66.549 -8.764  1.00 26.05  ? 871  ARG   A CG  1 
ATOM   4563 C  CD  . ARG   A 1 608 ? -31.793 -67.818 -9.512  1.00 25.91  ? 871  ARG   A CD  1 
ATOM   4564 N  NE  . ARG   A 1 608 ? -31.628 -67.637 -10.923 1.00 28.96  ? 871  ARG   A NE  1 
ATOM   4565 C  CZ  . ARG   A 1 608 ? -31.567 -68.608 -11.806 1.00 33.16  ? 871  ARG   A CZ  1 
ATOM   4566 N  NH1 . ARG   A 1 608 ? -31.654 -69.868 -11.416 1.00 39.78  ? 871  ARG   A NH1 1 
ATOM   4567 N  NH2 . ARG   A 1 608 ? -31.386 -68.321 -13.084 1.00 30.94  ? 871  ARG   A NH2 1 
ATOM   4568 N  N   . SER   A 1 609 ? -31.818 -66.519 -4.172  1.00 27.23  ? 872  SER   A N   1 
ATOM   4569 C  CA  . SER   A 1 609 ? -32.421 -66.746 -2.828  1.00 28.05  ? 872  SER   A CA  1 
ATOM   4570 C  C   . SER   A 1 609 ? -32.524 -65.423 -2.068  1.00 24.37  ? 872  SER   A C   1 
ATOM   4571 O  O   . SER   A 1 609 ? -33.461 -65.253 -1.303  1.00 25.90  ? 872  SER   A O   1 
ATOM   4572 C  CB  . SER   A 1 609 ? -31.667 -67.755 -2.034  1.00 27.70  ? 872  SER   A CB  1 
ATOM   4573 O  OG  . SER   A 1 609 ? -31.607 -69.005 -2.724  1.00 28.39  ? 872  SER   A OG  1 
ATOM   4574 N  N   . LEU   A 1 610 ? -31.555 -64.528 -2.175  1.00 24.81  ? 873  LEU   A N   1 
ATOM   4575 C  CA  . LEU   A 1 610 ? -31.631 -63.220 -1.471  1.00 24.56  ? 873  LEU   A CA  1 
ATOM   4576 C  C   . LEU   A 1 610 ? -32.757 -62.370 -2.090  1.00 24.56  ? 873  LEU   A C   1 
ATOM   4577 O  O   . LEU   A 1 610 ? -33.491 -61.691 -1.358  1.00 23.69  ? 873  LEU   A O   1 
ATOM   4578 C  CB  . LEU   A 1 610 ? -30.246 -62.555 -1.546  1.00 26.07  ? 873  LEU   A CB  1 
ATOM   4579 C  CG  . LEU   A 1 610 ? -29.140 -63.212 -0.730  1.00 25.13  ? 873  LEU   A CG  1 
ATOM   4580 C  CD1 . LEU   A 1 610 ? -27.770 -62.603 -1.029  1.00 30.80  ? 873  LEU   A CD1 1 
ATOM   4581 C  CD2 . LEU   A 1 610 ? -29.439 -63.129 0.770   1.00 25.96  ? 873  LEU   A CD2 1 
ATOM   4582 N  N   . ILE   A 1 611 ? -32.852 -62.315 -3.412  1.00 27.00  ? 874  ILE   A N   1 
ATOM   4583 C  CA  . ILE   A 1 611 ? -33.813 -61.406 -4.111  1.00 24.85  ? 874  ILE   A CA  1 
ATOM   4584 C  C   . ILE   A 1 611 ? -35.233 -61.982 -3.906  1.00 28.93  ? 874  ILE   A C   1 
ATOM   4585 O  O   . ILE   A 1 611 ? -36.153 -61.216 -3.610  1.00 29.05  ? 874  ILE   A O   1 
ATOM   4586 C  CB  . ILE   A 1 611 ? -33.428 -61.237 -5.601  1.00 28.64  ? 874  ILE   A CB  1 
ATOM   4587 C  CG1 . ILE   A 1 611 ? -32.108 -60.482 -5.720  1.00 27.92  ? 874  ILE   A CG1 1 
ATOM   4588 C  CG2 . ILE   A 1 611 ? -34.550 -60.502 -6.347  1.00 28.95  ? 874  ILE   A CG2 1 
ATOM   4589 C  CD1 . ILE   A 1 611 ? -31.508 -60.372 -7.086  1.00 28.14  ? 874  ILE   A CD1 1 
ATOM   4590 N  N   . GLY   A 1 612 ? -35.375 -63.305 -3.998  1.00 27.76  ? 875  GLY   A N   1 
ATOM   4591 C  CA  . GLY   A 1 612 ? -36.590 -64.087 -3.634  1.00 33.62  ? 875  GLY   A CA  1 
ATOM   4592 C  C   . GLY   A 1 612 ? -37.200 -64.809 -4.842  1.00 31.82  ? 875  GLY   A C   1 
ATOM   4593 O  O   . GLY   A 1 612 ? -36.613 -64.799 -5.924  1.00 28.46  ? 875  GLY   A O   1 
ATOM   4594 N  N   . ASN   A 1 613 ? -38.485 -65.114 -4.765  1.00 38.54  ? 876  ASN   A N   1 
ATOM   4595 C  CA  . ASN   A 1 613 ? -39.233 -65.938 -5.754  1.00 39.81  ? 876  ASN   A CA  1 
ATOM   4596 C  C   . ASN   A 1 613 ? -39.748 -65.070 -6.922  1.00 41.89  ? 876  ASN   A C   1 
ATOM   4597 O  O   . ASN   A 1 613 ? -40.924 -64.707 -6.951  1.00 47.20  ? 876  ASN   A O   1 
ATOM   4598 C  CB  . ASN   A 1 613 ? -40.369 -66.652 -5.020  1.00 46.74  ? 876  ASN   A CB  1 
ATOM   4599 C  CG  . ASN   A 1 613 ? -41.066 -67.663 -5.901  1.00 57.53  ? 876  ASN   A CG  1 
ATOM   4600 O  OD1 . ASN   A 1 613 ? -40.499 -68.111 -6.894  1.00 52.97  ? 876  ASN   A OD1 1 
ATOM   4601 N  ND2 . ASN   A 1 613 ? -42.277 -68.051 -5.522  1.00 62.56  ? 876  ASN   A ND2 1 
ATOM   4602 N  N   . GLU   A 1 614 ? -38.912 -64.848 -7.915  1.00 33.99  ? 877  GLU   A N   1 
ATOM   4603 C  CA  . GLU   A 1 614 ? -39.106 -63.898 -9.026  1.00 30.16  ? 877  GLU   A CA  1 
ATOM   4604 C  C   . GLU   A 1 614 ? -38.946 -64.742 -10.280 1.00 30.60  ? 877  GLU   A C   1 
ATOM   4605 O  O   . GLU   A 1 614 ? -38.670 -65.937 -10.151 1.00 29.59  ? 877  GLU   A O   1 
ATOM   4606 C  CB  . GLU   A 1 614 ? -38.047 -62.791 -8.939  1.00 30.77  ? 877  GLU   A CB  1 
ATOM   4607 C  CG  . GLU   A 1 614 ? -38.221 -61.875 -7.757  1.00 29.38  ? 877  GLU   A CG  1 
ATOM   4608 C  CD  . GLU   A 1 614 ? -39.418 -60.932 -7.787  1.00 33.66  ? 877  GLU   A CD  1 
ATOM   4609 O  OE1 . GLU   A 1 614 ? -40.038 -60.698 -8.863  1.00 31.01  ? 877  GLU   A OE1 1 
ATOM   4610 O  OE2 . GLU   A 1 614 ? -39.675 -60.364 -6.731  1.00 32.53  ? 877  GLU   A OE2 1 
ATOM   4611 N  N   . GLU   A 1 615 ? -39.147 -64.181 -11.457 1.00 33.04  ? 878  GLU   A N   1 
ATOM   4612 C  CA  . GLU   A 1 615 ? -38.931 -64.972 -12.705 1.00 37.78  ? 878  GLU   A CA  1 
ATOM   4613 C  C   . GLU   A 1 615 ? -37.497 -64.680 -13.154 1.00 33.33  ? 878  GLU   A C   1 
ATOM   4614 O  O   . GLU   A 1 615 ? -37.216 -63.478 -13.477 1.00 35.36  ? 878  GLU   A O   1 
ATOM   4615 C  CB  . GLU   A 1 615 ? -39.883 -64.599 -13.853 1.00 42.63  ? 878  GLU   A CB  1 
ATOM   4616 C  CG  . GLU   A 1 615 ? -39.708 -65.534 -15.058 1.00 54.80  ? 878  GLU   A CG  1 
ATOM   4617 C  CD  . GLU   A 1 615 ? -40.357 -65.099 -16.372 1.00 72.22  ? 878  GLU   A CD  1 
ATOM   4618 O  OE1 . GLU   A 1 615 ? -41.360 -64.308 -16.347 1.00 62.61  ? 878  GLU   A OE1 1 
ATOM   4619 O  OE2 . GLU   A 1 615 ? -39.863 -65.558 -17.438 1.00 85.13  ? 878  GLU   A OE2 1 
ATOM   4620 N  N   . TYR   A 1 616 ? -36.695 -65.731 -13.276 1.00 34.87  ? 879  TYR   A N   1 
ATOM   4621 C  CA  . TYR   A 1 616 ? -35.297 -65.724 -13.748 1.00 35.82  ? 879  TYR   A CA  1 
ATOM   4622 C  C   . TYR   A 1 616 ? -35.136 -66.595 -14.994 1.00 41.53  ? 879  TYR   A C   1 
ATOM   4623 O  O   . TYR   A 1 616 ? -35.873 -67.574 -15.130 1.00 34.70  ? 879  TYR   A O   1 
ATOM   4624 C  CB  . TYR   A 1 616 ? -34.388 -66.269 -12.658 1.00 36.07  ? 879  TYR   A CB  1 
ATOM   4625 C  CG  . TYR   A 1 616 ? -34.503 -65.589 -11.319 1.00 29.11  ? 879  TYR   A CG  1 
ATOM   4626 C  CD1 . TYR   A 1 616 ? -33.720 -64.505 -10.976 1.00 27.18  ? 879  TYR   A CD1 1 
ATOM   4627 C  CD2 . TYR   A 1 616 ? -35.322 -66.152 -10.347 1.00 31.39  ? 879  TYR   A CD2 1 
ATOM   4628 C  CE1 . TYR   A 1 616 ? -33.797 -63.939 -9.696  1.00 27.85  ? 879  TYR   A CE1 1 
ATOM   4629 C  CE2 . TYR   A 1 616 ? -35.430 -65.603 -9.077  1.00 26.87  ? 879  TYR   A CE2 1 
ATOM   4630 C  CZ  . TYR   A 1 616 ? -34.644 -64.511 -8.751  1.00 29.59  ? 879  TYR   A CZ  1 
ATOM   4631 O  OH  . TYR   A 1 616 ? -34.713 -64.003 -7.499  1.00 30.86  ? 879  TYR   A OH  1 
ATOM   4632 N  N   . THR   A 1 617 ? -34.171 -66.232 -15.857 1.00 40.17  ? 880  THR   A N   1 
ATOM   4633 C  CA  . THR   A 1 617 ? -33.662 -67.025 -17.026 1.00 39.82  ? 880  THR   A CA  1 
ATOM   4634 C  C   . THR   A 1 617 ? -32.234 -67.535 -16.749 1.00 38.14  ? 880  THR   A C   1 
ATOM   4635 O  O   . THR   A 1 617 ? -31.407 -66.753 -16.170 1.00 32.17  ? 880  THR   A O   1 
ATOM   4636 C  CB  . THR   A 1 617 ? -33.624 -66.125 -18.264 1.00 44.67  ? 880  THR   A CB  1 
ATOM   4637 O  OG1 . THR   A 1 617 ? -34.929 -65.543 -18.356 1.00 38.92  ? 880  THR   A OG1 1 
ATOM   4638 C  CG2 . THR   A 1 617 ? -33.228 -66.836 -19.547 1.00 42.35  ? 880  THR   A CG2 1 
ATOM   4639 N  N   . ASP   A 1 618 ? -31.928 -68.777 -17.117 1.00 33.97  ? 881  ASP   A N   1 
ATOM   4640 C  CA  . ASP   A 1 618 ? -30.529 -69.287 -17.111 1.00 38.78  ? 881  ASP   A CA  1 
ATOM   4641 C  C   . ASP   A 1 618 ? -29.848 -68.872 -18.432 1.00 38.38  ? 881  ASP   A C   1 
ATOM   4642 O  O   . ASP   A 1 618 ? -30.111 -69.511 -19.477 1.00 32.76  ? 881  ASP   A O   1 
ATOM   4643 C  CB  . ASP   A 1 618 ? -30.462 -70.805 -16.903 1.00 42.41  ? 881  ASP   A CB  1 
ATOM   4644 C  CG  . ASP   A 1 618 ? -29.043 -71.389 -16.781 1.00 49.60  ? 881  ASP   A CG  1 
ATOM   4645 O  OD1 . ASP   A 1 618 ? -28.069 -70.619 -16.547 1.00 42.07  ? 881  ASP   A OD1 1 
ATOM   4646 O  OD2 . ASP   A 1 618 ? -28.914 -72.627 -16.878 1.00 50.40  ? 881  ASP   A OD2 1 
ATOM   4647 N  N   . TYR   A 1 619 ? -28.910 -67.917 -18.384 1.00 33.33  ? 882  TYR   A N   1 
ATOM   4648 C  CA  . TYR   A 1 619 ? -28.088 -67.563 -19.571 1.00 32.63  ? 882  TYR   A CA  1 
ATOM   4649 C  C   . TYR   A 1 619 ? -26.771 -68.346 -19.639 1.00 35.39  ? 882  TYR   A C   1 
ATOM   4650 O  O   . TYR   A 1 619 ? -26.065 -68.171 -20.647 1.00 34.50  ? 882  TYR   A O   1 
ATOM   4651 C  CB  . TYR   A 1 619 ? -27.817 -66.067 -19.588 1.00 34.56  ? 882  TYR   A CB  1 
ATOM   4652 C  CG  . TYR   A 1 619 ? -29.057 -65.247 -19.772 1.00 40.49  ? 882  TYR   A CG  1 
ATOM   4653 C  CD1 . TYR   A 1 619 ? -29.692 -65.161 -21.009 1.00 39.09  ? 882  TYR   A CD1 1 
ATOM   4654 C  CD2 . TYR   A 1 619 ? -29.608 -64.571 -18.703 1.00 32.70  ? 882  TYR   A CD2 1 
ATOM   4655 C  CE1 . TYR   A 1 619 ? -30.844 -64.404 -21.170 1.00 38.71  ? 882  TYR   A CE1 1 
ATOM   4656 C  CE2 . TYR   A 1 619 ? -30.737 -63.775 -18.859 1.00 36.52  ? 882  TYR   A CE2 1 
ATOM   4657 C  CZ  . TYR   A 1 619 ? -31.366 -63.700 -20.091 1.00 39.51  ? 882  TYR   A CZ  1 
ATOM   4658 O  OH  . TYR   A 1 619 ? -32.456 -62.890 -20.210 1.00 41.48  ? 882  TYR   A OH  1 
ATOM   4659 N  N   . MET   A 1 620 ? -26.420 -69.193 -18.663 1.00 37.78  ? 883  MET   A N   1 
ATOM   4660 C  CA  . MET   A 1 620 ? -25.103 -69.902 -18.704 1.00 35.93  ? 883  MET   A CA  1 
ATOM   4661 C  C   . MET   A 1 620 ? -24.989 -70.863 -19.908 1.00 36.74  ? 883  MET   A C   1 
ATOM   4662 O  O   . MET   A 1 620 ? -23.903 -70.906 -20.499 1.00 45.24  ? 883  MET   A O   1 
ATOM   4663 C  CB  . MET   A 1 620 ? -24.711 -70.596 -17.396 1.00 33.68  ? 883  MET   A CB  1 
ATOM   4664 C  CG  . MET   A 1 620 ? -24.793 -69.721 -16.140 1.00 33.32  ? 883  MET   A CG  1 
ATOM   4665 S  SD  . MET   A 1 620 ? -24.053 -68.042 -16.272 1.00 33.75  ? 883  MET   A SD  1 
ATOM   4666 C  CE  . MET   A 1 620 ? -22.325 -68.463 -16.510 1.00 32.44  ? 883  MET   A CE  1 
ATOM   4667 N  N   . PRO   A 1 621 ? -26.017 -71.645 -20.331 1.00 43.68  ? 884  PRO   A N   1 
ATOM   4668 C  CA  . PRO   A 1 621 ? -25.903 -72.499 -21.538 1.00 47.44  ? 884  PRO   A CA  1 
ATOM   4669 C  C   . PRO   A 1 621 ? -25.606 -71.850 -22.909 1.00 51.92  ? 884  PRO   A C   1 
ATOM   4670 O  O   . PRO   A 1 621 ? -25.268 -72.625 -23.810 1.00 50.84  ? 884  PRO   A O   1 
ATOM   4671 C  CB  . PRO   A 1 621 ? -27.278 -73.218 -21.612 1.00 48.27  ? 884  PRO   A CB  1 
ATOM   4672 C  CG  . PRO   A 1 621 ? -27.773 -73.263 -20.170 1.00 45.05  ? 884  PRO   A CG  1 
ATOM   4673 C  CD  . PRO   A 1 621 ? -27.252 -71.962 -19.569 1.00 48.19  ? 884  PRO   A CD  1 
ATOM   4674 N  N   . SER   A 1 622 ? -25.667 -70.498 -23.032 1.00 49.98  ? 885  SER   A N   1 
ATOM   4675 C  CA  . SER   A 1 622 ? -25.145 -69.672 -24.172 1.00 51.45  ? 885  SER   A CA  1 
ATOM   4676 C  C   . SER   A 1 622 ? -23.615 -69.836 -24.333 1.00 52.87  ? 885  SER   A C   1 
ATOM   4677 O  O   . SER   A 1 622 ? -23.089 -69.519 -25.442 1.00 51.74  ? 885  SER   A O   1 
ATOM   4678 C  CB  . SER   A 1 622 ? -25.547 -68.177 -24.064 1.00 52.01  ? 885  SER   A CB  1 
ATOM   4679 O  OG  . SER   A 1 622 ? -24.838 -67.456 -23.037 1.00 42.11  ? 885  SER   A OG  1 
ATOM   4680 N  N   . MET   A 1 623 ? -22.921 -70.323 -23.292 1.00 45.63  ? 886  MET   A N   1 
ATOM   4681 C  CA  . MET   A 1 623 ? -21.461 -70.608 -23.321 1.00 58.15  ? 886  MET   A CA  1 
ATOM   4682 C  C   . MET   A 1 623 ? -21.242 -72.118 -23.499 1.00 57.48  ? 886  MET   A C   1 
ATOM   4683 O  O   . MET   A 1 623 ? -21.897 -72.888 -22.738 1.00 47.71  ? 886  MET   A O   1 
ATOM   4684 C  CB  . MET   A 1 623 ? -20.776 -70.159 -22.023 1.00 56.52  ? 886  MET   A CB  1 
ATOM   4685 C  CG  . MET   A 1 623 ? -21.367 -68.914 -21.408 1.00 58.37  ? 886  MET   A CG  1 
ATOM   4686 S  SD  . MET   A 1 623 ? -20.408 -68.387 -19.949 1.00 48.80  ? 886  MET   A SD  1 
ATOM   4687 C  CE  . MET   A 1 623 ? -18.997 -67.661 -20.757 1.00 41.69  ? 886  MET   A CE  1 
ATOM   4688 N  N   . LYS   A 1 624 ? -20.303 -72.507 -24.379 1.00 64.06  ? 887  LYS   A N   1 
ATOM   4689 C  CA  . LYS   A 1 624 ? -20.022 -73.923 -24.756 1.00 69.18  ? 887  LYS   A CA  1 
ATOM   4690 C  C   . LYS   A 1 624 ? -19.883 -74.823 -23.516 1.00 65.78  ? 887  LYS   A C   1 
ATOM   4691 O  O   . LYS   A 1 624 ? -20.453 -75.931 -23.543 1.00 60.21  ? 887  LYS   A O   1 
ATOM   4692 C  CB  . LYS   A 1 624 ? -18.746 -74.086 -25.596 1.00 76.03  ? 887  LYS   A CB  1 
ATOM   4693 C  CG  . LYS   A 1 624 ? -18.463 -75.542 -25.974 1.00 82.94  ? 887  LYS   A CG  1 
ATOM   4694 C  CD  . LYS   A 1 624 ? -17.527 -75.766 -27.154 1.00 91.48  ? 887  LYS   A CD  1 
ATOM   4695 C  CE  . LYS   A 1 624 ? -16.082 -75.978 -26.744 1.00 94.92  ? 887  LYS   A CE  1 
ATOM   4696 N  NZ  . LYS   A 1 624 ? -15.467 -74.717 -26.262 1.00 98.05  ? 887  LYS   A NZ  1 
ATOM   4697 N  N   . ARG   A 1 625 ? -19.125 -74.403 -22.492 1.00 63.56  ? 888  ARG   A N   1 
ATOM   4698 C  CA  . ARG   A 1 625 ? -18.762 -75.273 -21.325 1.00 62.10  ? 888  ARG   A CA  1 
ATOM   4699 C  C   . ARG   A 1 625 ? -19.986 -75.642 -20.454 1.00 60.51  ? 888  ARG   A C   1 
ATOM   4700 O  O   . ARG   A 1 625 ? -19.874 -76.634 -19.719 1.00 54.38  ? 888  ARG   A O   1 
ATOM   4701 C  CB  . ARG   A 1 625 ? -17.681 -74.616 -20.454 1.00 60.66  ? 888  ARG   A CB  1 
ATOM   4702 C  CG  . ARG   A 1 625 ? -18.096 -73.329 -19.741 1.00 61.27  ? 888  ARG   A CG  1 
ATOM   4703 C  CD  . ARG   A 1 625 ? -17.093 -72.855 -18.682 1.00 58.28  ? 888  ARG   A CD  1 
ATOM   4704 N  NE  . ARG   A 1 625 ? -16.935 -73.841 -17.613 1.00 59.63  ? 888  ARG   A NE  1 
ATOM   4705 C  CZ  . ARG   A 1 625 ? -15.864 -74.001 -16.828 1.00 54.06  ? 888  ARG   A CZ  1 
ATOM   4706 N  NH1 . ARG   A 1 625 ? -14.802 -73.210 -16.938 1.00 61.67  ? 888  ARG   A NH1 1 
ATOM   4707 N  NH2 . ARG   A 1 625 ? -15.880 -74.955 -15.910 1.00 53.57  ? 888  ARG   A NH2 1 
ATOM   4708 N  N   . PHE   A 1 626 ? -21.079 -74.857 -20.457 1.00 61.05  ? 889  PHE   A N   1 
ATOM   4709 C  CA  . PHE   A 1 626 ? -22.328 -75.123 -19.677 1.00 61.34  ? 889  PHE   A CA  1 
ATOM   4710 C  C   . PHE   A 1 626 ? -23.396 -75.720 -20.615 1.00 68.15  ? 889  PHE   A C   1 
ATOM   4711 O  O   . PHE   A 1 626 ? -24.555 -76.030 -20.201 1.00 61.20  ? 889  PHE   A O   1 
ATOM   4712 C  CB  . PHE   A 1 626 ? -22.809 -73.841 -18.985 1.00 58.27  ? 889  PHE   A CB  1 
ATOM   4713 C  CG  . PHE   A 1 626 ? -21.783 -73.207 -18.072 1.00 62.95  ? 889  PHE   A CG  1 
ATOM   4714 C  CD1 . PHE   A 1 626 ? -21.364 -73.850 -16.908 1.00 61.36  ? 889  PHE   A CD1 1 
ATOM   4715 C  CD2 . PHE   A 1 626 ? -21.222 -71.975 -18.386 1.00 55.46  ? 889  PHE   A CD2 1 
ATOM   4716 C  CE1 . PHE   A 1 626 ? -20.396 -73.284 -16.085 1.00 64.82  ? 889  PHE   A CE1 1 
ATOM   4717 C  CE2 . PHE   A 1 626 ? -20.265 -71.400 -17.556 1.00 59.44  ? 889  PHE   A CE2 1 
ATOM   4718 C  CZ  . PHE   A 1 626 ? -19.853 -72.051 -16.405 1.00 60.37  ? 889  PHE   A CZ  1 
ATOM   4719 N  N   . ARG   A 1 627 ? -23.038 -75.821 -21.889 1.00 75.86  ? 890  ARG   A N   1 
ATOM   4720 C  CA  . ARG   A 1 627 ? -23.815 -76.551 -22.916 1.00 99.32  ? 890  ARG   A CA  1 
ATOM   4721 C  C   . ARG   A 1 627 ? -23.323 -78.013 -22.882 1.00 112.28 ? 890  ARG   A C   1 
ATOM   4722 O  O   . ARG   A 1 627 ? -22.397 -78.345 -23.655 1.00 123.93 ? 890  ARG   A O   1 
ATOM   4723 C  CB  . ARG   A 1 627 ? -23.651 -75.796 -24.245 1.00 99.78  ? 890  ARG   A CB  1 
ATOM   4724 C  CG  . ARG   A 1 627 ? -24.896 -75.746 -25.119 1.00 96.89  ? 890  ARG   A CG  1 
ATOM   4725 C  CD  . ARG   A 1 627 ? -24.644 -75.042 -26.440 1.00 97.26  ? 890  ARG   A CD  1 
ATOM   4726 N  NE  . ARG   A 1 627 ? -23.293 -75.261 -26.957 1.00 96.34  ? 890  ARG   A NE  1 
ATOM   4727 C  CZ  . ARG   A 1 627 ? -22.888 -76.293 -27.704 1.00 96.98  ? 890  ARG   A CZ  1 
ATOM   4728 N  NH1 . ARG   A 1 627 ? -23.725 -77.257 -28.051 1.00 106.69 ? 890  ARG   A NH1 1 
ATOM   4729 N  NH2 . ARG   A 1 627 ? -21.632 -76.362 -28.113 1.00 93.46  ? 890  ARG   A NH2 1 
ATOM   4730 N  N   . ARG   A 1 628 ? -23.839 -78.812 -21.930 1.00 121.35 ? 891  ARG   A N   1 
ATOM   4731 C  CA  . ARG   A 1 628 ? -23.825 -80.308 -21.924 1.00 125.22 ? 891  ARG   A CA  1 
ATOM   4732 C  C   . ARG   A 1 628 ? -22.496 -80.881 -22.432 1.00 112.21 ? 891  ARG   A C   1 
ATOM   4733 O  O   . ARG   A 1 628 ? -21.418 -80.489 -22.017 1.00 106.57 ? 891  ARG   A O   1 
ATOM   4734 C  CB  . ARG   A 1 628 ? -24.946 -80.832 -22.826 1.00 125.79 ? 891  ARG   A CB  1 
ATOM   4735 C  CG  . ARG   A 1 628 ? -26.315 -80.239 -22.522 1.00 122.74 ? 891  ARG   A CG  1 
ATOM   4736 C  CD  . ARG   A 1 628 ? -26.684 -80.368 -21.058 1.00 118.74 ? 891  ARG   A CD  1 
ATOM   4737 N  NE  . ARG   A 1 628 ? -26.481 -81.733 -20.588 1.00 120.01 ? 891  ARG   A NE  1 
ATOM   4738 C  CZ  . ARG   A 1 628 ? -26.754 -82.166 -19.364 1.00 115.86 ? 891  ARG   A CZ  1 
ATOM   4739 N  NH1 . ARG   A 1 628 ? -27.244 -81.344 -18.453 1.00 123.50 ? 891  ARG   A NH1 1 
ATOM   4740 N  NH2 . ARG   A 1 628 ? -26.535 -83.428 -19.050 1.00 113.22 ? 891  ARG   A NH2 1 
HETATM 4741 ZN ZN  . ZN    B 2 .   ? -6.526  -55.534 -23.819 1.00 22.32  2 1001 ZN    A ZN  1 
HETATM 4742 ZN ZN  . ZN    C 2 .   ? -25.971 -14.754 -13.402 1.00 53.99  2 1002 ZN    A ZN  1 
HETATM 4743 O  O1  A MES   D 3 .   ? -28.467 -57.833 0.445   0.25 29.83  ? 1003 MES   A O1  1 
HETATM 4744 O  O1  B MES   D 3 .   ? -28.199 -57.663 0.349   0.25 638.20 ? 1003 MES   A O1  1 
HETATM 4745 C  C2  A MES   D 3 .   ? -27.855 -58.229 1.666   0.25 27.41  ? 1003 MES   A C2  1 
HETATM 4746 C  C2  B MES   D 3 .   ? -27.447 -58.100 1.471   0.25 645.25 ? 1003 MES   A C2  1 
HETATM 4747 C  C3  A MES   D 3 .   ? -26.413 -57.788 1.705   0.25 27.14  ? 1003 MES   A C3  1 
HETATM 4748 C  C3  B MES   D 3 .   ? -25.968 -58.087 1.177   0.25 645.71 ? 1003 MES   A C3  1 
HETATM 4749 N  N4  A MES   D 3 .   ? -25.662 -58.412 0.571   0.25 24.49  ? 1003 MES   A N4  1 
HETATM 4750 N  N4  B MES   D 3 .   ? -25.675 -58.970 0.006   0.25 643.01 ? 1003 MES   A N4  1 
HETATM 4751 C  C5  A MES   D 3 .   ? -26.341 -58.086 -0.714  0.25 26.27  ? 1003 MES   A C5  1 
HETATM 4752 C  C5  B MES   D 3 .   ? -26.511 -58.528 -1.152  0.25 635.78 ? 1003 MES   A C5  1 
HETATM 4753 C  C6  A MES   D 3 .   ? -27.810 -58.435 -0.660  0.25 28.59  ? 1003 MES   A C6  1 
HETATM 4754 C  C6  B MES   D 3 .   ? -27.966 -58.521 -0.757  0.25 629.15 ? 1003 MES   A C6  1 
HETATM 4755 C  C7  A MES   D 3 .   ? -24.219 -57.998 0.557   0.25 24.50  ? 1003 MES   A C7  1 
HETATM 4756 C  C7  B MES   D 3 .   ? -24.214 -58.986 -0.340  0.25 645.14 ? 1003 MES   A C7  1 
HETATM 4757 C  C8  A MES   D 3 .   ? -23.361 -58.954 -0.248  0.25 25.29  ? 1003 MES   A C8  1 
HETATM 4758 C  C8  B MES   D 3 .   ? -23.419 -57.898 0.354   0.25 656.57 ? 1003 MES   A C8  1 
HETATM 4759 S  S   A MES   D 3 .   ? -21.616 -58.896 0.142   0.25 24.28  ? 1003 MES   A S   1 
HETATM 4760 S  S   B MES   D 3 .   ? -21.678 -58.259 0.396   0.25 675.14 ? 1003 MES   A S   1 
HETATM 4761 O  O1S A MES   D 3 .   ? -21.285 -60.245 0.450   0.25 27.65  ? 1003 MES   A O1S 1 
HETATM 4762 O  O1S B MES   D 3 .   ? -21.564 -59.682 0.242   0.25 682.34 ? 1003 MES   A O1S 1 
HETATM 4763 O  O2S A MES   D 3 .   ? -20.982 -58.417 -1.051  0.25 24.10  ? 1003 MES   A O2S 1 
HETATM 4764 O  O2S B MES   D 3 .   ? -21.094 -57.536 -0.699  0.25 669.91 ? 1003 MES   A O2S 1 
HETATM 4765 O  O3S A MES   D 3 .   ? -21.430 -58.028 1.262   0.25 26.69  ? 1003 MES   A O3S 1 
HETATM 4766 O  O3S B MES   D 3 .   ? -21.207 -57.802 1.673   0.25 678.38 ? 1003 MES   A O3S 1 
HETATM 4767 S  S   . DMS   E 4 .   ? -26.880 -62.267 -20.986 1.00 50.65  ? 1004 DMS   A S   1 
HETATM 4768 O  O   . DMS   E 4 .   ? -26.635 -62.813 -22.450 1.00 55.50  ? 1004 DMS   A O   1 
HETATM 4769 C  C1  . DMS   E 4 .   ? -28.188 -61.078 -21.131 1.00 41.97  ? 1004 DMS   A C1  1 
HETATM 4770 C  C2  . DMS   E 4 .   ? -25.550 -61.073 -20.830 1.00 54.22  ? 1004 DMS   A C2  1 
HETATM 4771 S  S   . DMS   F 4 .   ? -15.947 -69.714 -29.050 1.00 126.84 ? 1005 DMS   A S   1 
HETATM 4772 O  O   . DMS   F 4 .   ? -16.326 -68.259 -29.292 1.00 76.78  ? 1005 DMS   A O   1 
HETATM 4773 C  C1  . DMS   F 4 .   ? -16.930 -70.277 -27.666 1.00 98.19  ? 1005 DMS   A C1  1 
HETATM 4774 C  C2  . DMS   F 4 .   ? -14.351 -69.715 -28.253 1.00 106.91 ? 1005 DMS   A C2  1 
HETATM 4775 P  P   . PO4   G 5 .   ? -4.137  -39.709 -24.227 1.00 69.78  ? 1006 PO4   A P   1 
HETATM 4776 O  O1  . PO4   G 5 .   ? -2.783  -40.373 -23.537 1.00 40.13  ? 1006 PO4   A O1  1 
HETATM 4777 O  O2  . PO4   G 5 .   ? -3.801  -38.150 -24.797 1.00 40.41  ? 1006 PO4   A O2  1 
HETATM 4778 O  O3  . PO4   G 5 .   ? -4.749  -40.550 -25.480 1.00 42.35  ? 1006 PO4   A O3  1 
HETATM 4779 O  O4  . PO4   G 5 .   ? -5.146  -39.766 -23.154 1.00 59.19  ? 1006 PO4   A O4  1 
HETATM 4780 P  P   . PO4   H 5 .   ? -18.193 -9.641  -29.186 1.00 113.68 ? 1007 PO4   A P   1 
HETATM 4781 O  O1  . PO4   H 5 .   ? -17.857 -10.138 -27.746 1.00 72.65  ? 1007 PO4   A O1  1 
HETATM 4782 O  O2  . PO4   H 5 .   ? -16.865 -9.381  -29.913 1.00 99.36  ? 1007 PO4   A O2  1 
HETATM 4783 O  O3  . PO4   H 5 .   ? -19.027 -10.729 -29.958 1.00 78.58  ? 1007 PO4   A O3  1 
HETATM 4784 O  O4  . PO4   H 5 .   ? -19.011 -8.307  -29.133 1.00 84.49  ? 1007 PO4   A O4  1 
HETATM 4785 C  C1  . PEG   I 6 .   ? -17.172 -44.038 -41.121 1.00 65.21  ? 1008 PEG   A C1  1 
HETATM 4786 O  O1  . PEG   I 6 .   ? -18.399 -44.196 -41.808 1.00 64.71  ? 1008 PEG   A O1  1 
HETATM 4787 C  C2  . PEG   I 6 .   ? -16.033 -44.462 -41.977 1.00 69.22  ? 1008 PEG   A C2  1 
HETATM 4788 O  O2  . PEG   I 6 .   ? -16.341 -45.739 -42.537 1.00 77.80  ? 1008 PEG   A O2  1 
HETATM 4789 C  C3  . PEG   I 6 .   ? -15.913 -45.906 -43.888 1.00 79.71  ? 1008 PEG   A C3  1 
HETATM 4790 C  C4  . PEG   I 6 .   ? -15.019 -47.110 -44.000 1.00 81.40  ? 1008 PEG   A C4  1 
HETATM 4791 O  O4  . PEG   I 6 .   ? -15.696 -48.246 -44.524 1.00 73.05  ? 1008 PEG   A O4  1 
HETATM 4792 N  N1  . A1BZQ J 7 .   ? -19.433 -46.110 -21.487 0.25 36.51  ? 1009 A1BZQ A N1  1 
HETATM 4793 C  C4  . A1BZQ J 7 .   ? -21.317 -45.296 -18.324 0.25 33.78  ? 1009 A1BZQ A C4  1 
HETATM 4794 C  C5  . A1BZQ J 7 .   ? -20.703 -44.045 -17.710 0.25 34.43  ? 1009 A1BZQ A C5  1 
HETATM 4795 C  C6  . A1BZQ J 7 .   ? -20.477 -45.836 -19.441 0.25 35.83  ? 1009 A1BZQ A C6  1 
HETATM 4796 C  C7  . A1BZQ J 7 .   ? -19.050 -47.192 -20.874 0.25 36.71  ? 1009 A1BZQ A C7  1 
HETATM 4797 C  C8  . A1BZQ J 7 .   ? -18.167 -48.223 -21.493 0.25 36.22  ? 1009 A1BZQ A C8  1 
HETATM 4798 C  C10 . A1BZQ J 7 .   ? -20.734 -44.037 -21.227 0.25 36.69  ? 1009 A1BZQ A C10 1 
HETATM 4799 N  N   . A1BZQ J 7 .   ? -21.462 -46.329 -17.314 0.25 32.53  ? 1009 A1BZQ A N   1 
HETATM 4800 C  C   . A1BZQ J 7 .   ? -22.645 -49.582 -16.726 0.25 28.56  ? 1009 A1BZQ A C   1 
HETATM 4801 O  O   . A1BZQ J 7 .   ? -23.383 -47.143 -18.155 0.25 32.09  ? 1009 A1BZQ A O   1 
HETATM 4802 C  C1  . A1BZQ J 7 .   ? -22.518 -48.183 -16.171 0.25 29.89  ? 1009 A1BZQ A C1  1 
HETATM 4803 C  C2  . A1BZQ J 7 .   ? -23.633 -47.844 -15.202 0.25 28.59  ? 1009 A1BZQ A C2  1 
HETATM 4804 C  C3  . A1BZQ J 7 .   ? -22.497 -47.173 -17.307 0.25 31.14  ? 1009 A1BZQ A C3  1 
HETATM 4805 C  C9  . A1BZQ J 7 .   ? -20.236 -45.335 -20.684 0.25 36.28  ? 1009 A1BZQ A C9  1 
HETATM 4806 S  S   . A1BZQ J 7 .   ? -19.650 -47.354 -19.256 0.25 38.78  ? 1009 A1BZQ A S   1 
HETATM 4807 CL CL  . CL    K 8 .   ? 4.162   -49.160 -29.858 1.00 40.46  ? 1010 CL    A CL  1 
HETATM 4808 O  O   . HOH   L 9 .   ? -12.912 -23.129 -42.278 0.28 34.35  ? 1101 HOH   A O   1 
HETATM 4809 O  O   . HOH   L 9 .   ? -32.045 -71.013 -8.842  1.00 49.86  ? 1102 HOH   A O   1 
HETATM 4810 O  O   . HOH   L 9 .   ? -7.653  -49.261 0.612   1.00 49.77  ? 1103 HOH   A O   1 
HETATM 4811 O  O   . HOH   L 9 .   ? -3.957  -37.867 -45.624 1.00 52.72  ? 1104 HOH   A O   1 
HETATM 4812 O  O   . HOH   L 9 .   ? -32.792 -52.260 -27.346 1.00 43.06  ? 1105 HOH   A O   1 
HETATM 4813 O  O   . HOH   L 9 .   ? -33.701 -47.846 -4.341  1.00 33.63  ? 1106 HOH   A O   1 
HETATM 4814 O  O   . HOH   L 9 .   ? 5.807   -45.197 -35.956 1.00 50.49  ? 1107 HOH   A O   1 
HETATM 4815 O  O   . HOH   L 9 .   ? -19.924 -66.596 -37.574 1.00 56.81  ? 1108 HOH   A O   1 
HETATM 4816 O  O   . HOH   L 9 .   ? -4.365  -54.821 -11.824 1.00 50.35  ? 1109 HOH   A O   1 
HETATM 4817 O  O   . HOH   L 9 .   ? -29.386 -56.518 -36.449 1.00 53.61  ? 1110 HOH   A O   1 
HETATM 4818 O  O   . HOH   L 9 .   ? -19.840 -9.873  -33.242 1.00 51.23  ? 1111 HOH   A O   1 
HETATM 4819 O  O   . HOH   L 9 .   ? -22.490 -53.965 -46.855 1.00 51.71  ? 1112 HOH   A O   1 
HETATM 4820 O  O   . HOH   L 9 .   ? -32.467 -60.813 -18.871 1.00 42.37  ? 1113 HOH   A O   1 
HETATM 4821 O  O   . HOH   L 9 .   ? -19.765 -27.720 -40.330 1.00 30.87  ? 1114 HOH   A O   1 
HETATM 4822 O  O   . HOH   L 9 .   ? -34.914 -20.992 -23.933 1.00 52.79  ? 1115 HOH   A O   1 
HETATM 4823 O  O   . HOH   L 9 .   ? -28.756 -70.048 -13.962 1.00 50.70  ? 1116 HOH   A O   1 
HETATM 4824 O  O   . HOH   L 9 .   ? -11.635 -12.150 -9.593  1.00 65.14  ? 1117 HOH   A O   1 
HETATM 4825 O  O   . HOH   L 9 .   ? -6.121  -12.421 -22.321 1.00 66.39  ? 1118 HOH   A O   1 
HETATM 4826 O  O   . HOH   L 9 .   ? -15.104 -54.771 -39.479 1.00 40.86  ? 1119 HOH   A O   1 
HETATM 4827 O  O   . HOH   L 9 .   ? -3.763  -55.795 -35.974 1.00 64.12  ? 1120 HOH   A O   1 
HETATM 4828 O  O   . HOH   L 9 .   ? -38.411 -67.861 -8.568  1.00 37.55  ? 1121 HOH   A O   1 
HETATM 4829 O  O   . HOH   L 9 .   ? -9.971  -64.612 -33.214 1.00 52.18  ? 1122 HOH   A O   1 
HETATM 4830 O  O   . HOH   L 9 .   ? -23.679 -46.722 -37.083 1.00 60.46  ? 1123 HOH   A O   1 
HETATM 4831 O  O   . HOH   L 9 .   ? -19.113 -45.238 -8.910  0.25 38.35  ? 1124 HOH   A O   1 
HETATM 4832 O  O   . HOH   L 9 .   ? 4.588   -16.544 -21.916 1.00 54.47  ? 1125 HOH   A O   1 
HETATM 4833 O  O   . HOH   L 9 .   ? -21.928 -10.171 -9.638  1.00 52.97  ? 1126 HOH   A O   1 
HETATM 4834 O  O   . HOH   L 9 .   ? -3.995  -15.551 -21.032 1.00 52.05  ? 1127 HOH   A O   1 
HETATM 4835 O  O   . HOH   L 9 .   ? 10.415  -38.792 -29.942 1.00 47.05  ? 1128 HOH   A O   1 
HETATM 4836 O  O   . HOH   L 9 .   ? 11.283  -34.531 -33.423 1.00 45.26  ? 1129 HOH   A O   1 
HETATM 4837 O  O   . HOH   L 9 .   ? -42.272 -63.411 -5.213  1.00 43.80  ? 1130 HOH   A O   1 
HETATM 4838 O  O   . HOH   L 9 .   ? -4.279  -53.925 -28.131 1.00 25.59  ? 1131 HOH   A O   1 
HETATM 4839 O  O   . HOH   L 9 .   ? -23.150 -65.408 -38.904 1.00 47.19  ? 1132 HOH   A O   1 
HETATM 4840 O  O   . HOH   L 9 .   ? -19.380 -20.919 -40.757 1.00 37.15  ? 1133 HOH   A O   1 
HETATM 4841 O  O   . HOH   L 9 .   ? 9.913   -25.582 -32.836 1.00 52.48  ? 1134 HOH   A O   1 
HETATM 4842 O  O   . HOH   L 9 .   ? -21.006 -47.353 -10.050 1.00 55.73  ? 1135 HOH   A O   1 
HETATM 4843 O  O   . HOH   L 9 .   ? 0.053   -33.073 -28.126 1.00 28.11  ? 1136 HOH   A O   1 
HETATM 4844 O  O   . HOH   L 9 .   ? -9.125  -37.187 -19.836 1.00 55.14  ? 1137 HOH   A O   1 
HETATM 4845 O  O   . HOH   L 9 .   ? -7.155  -20.496 -27.236 1.00 41.55  ? 1138 HOH   A O   1 
HETATM 4846 O  O   . HOH   L 9 .   ? -15.531 -22.199 -19.281 1.00 43.99  ? 1139 HOH   A O   1 
HETATM 4847 O  O   . HOH   L 9 .   ? -38.916 -57.485 -20.352 1.00 40.68  ? 1140 HOH   A O   1 
HETATM 4848 O  O   . HOH   L 9 .   ? -22.848 -44.942 -33.438 0.25 22.26  ? 1141 HOH   A O   1 
HETATM 4849 O  O   . HOH   L 9 .   ? -3.865  -61.791 -15.517 1.00 30.75  ? 1142 HOH   A O   1 
HETATM 4850 O  O   . HOH   L 9 .   ? -21.585 -49.788 -34.966 1.00 44.43  ? 1143 HOH   A O   1 
HETATM 4851 O  O   . HOH   L 9 .   ? -13.630 -13.103 -27.620 1.00 46.11  ? 1144 HOH   A O   1 
HETATM 4852 O  O   . HOH   L 9 .   ? -40.544 -57.934 -6.359  1.00 48.05  ? 1145 HOH   A O   1 
HETATM 4853 O  O   . HOH   L 9 .   ? 2.989   -51.549 -26.938 1.00 35.28  ? 1146 HOH   A O   1 
HETATM 4854 O  O   . HOH   L 9 .   ? 6.509   -35.370 -43.991 1.00 46.62  ? 1147 HOH   A O   1 
HETATM 4855 O  O   . HOH   L 9 .   ? -38.978 -61.195 -4.354  1.00 41.73  ? 1148 HOH   A O   1 
HETATM 4856 O  O   . HOH   L 9 .   ? -8.050  -43.202 -42.998 1.00 47.55  ? 1149 HOH   A O   1 
HETATM 4857 O  O   . HOH   L 9 .   ? 5.620   -20.151 -43.411 1.00 52.45  ? 1150 HOH   A O   1 
HETATM 4858 O  O   . HOH   L 9 .   ? -26.797 -25.894 -33.532 1.00 33.31  ? 1151 HOH   A O   1 
HETATM 4859 O  O   . HOH   L 9 .   ? -10.974 -62.582 -18.769 1.00 18.82  ? 1152 HOH   A O   1 
HETATM 4860 O  O   . HOH   L 9 .   ? -12.395 -58.428 -0.000  0.50 24.65  ? 1153 HOH   A O   1 
HETATM 4861 O  O   . HOH   L 9 .   ? -17.559 -42.000 -37.266 1.00 43.48  ? 1154 HOH   A O   1 
HETATM 4862 O  O   . HOH   L 9 .   ? -13.000 -53.823 -40.673 1.00 51.36  ? 1155 HOH   A O   1 
HETATM 4863 O  O   . HOH   L 9 .   ? -1.584  -41.640 -21.573 1.00 59.42  ? 1156 HOH   A O   1 
HETATM 4864 O  O   . HOH   L 9 .   ? -40.231 -61.575 -11.339 1.00 28.67  ? 1157 HOH   A O   1 
HETATM 4865 O  O   . HOH   L 9 .   ? -31.859 -57.547 -21.679 1.00 32.31  ? 1158 HOH   A O   1 
HETATM 4866 O  O   . HOH   L 9 .   ? -16.688 -32.517 -18.406 1.00 51.08  ? 1159 HOH   A O   1 
HETATM 4867 O  O   . HOH   L 9 .   ? -7.377  -47.519 -18.246 1.00 32.10  ? 1160 HOH   A O   1 
HETATM 4868 O  O   . HOH   L 9 .   ? -8.391  -65.084 -7.009  1.00 30.28  ? 1161 HOH   A O   1 
HETATM 4869 O  O   . HOH   L 9 .   ? -20.783 -29.456 -25.101 1.00 42.25  ? 1162 HOH   A O   1 
HETATM 4870 O  O   . HOH   L 9 .   ? -29.990 -50.707 -27.063 1.00 41.36  ? 1163 HOH   A O   1 
HETATM 4871 O  O   . HOH   L 9 .   ? -27.041 -66.037 -40.011 1.00 43.78  ? 1164 HOH   A O   1 
HETATM 4872 O  O   . HOH   L 9 .   ? -38.410 -61.243 -14.251 1.00 35.10  ? 1165 HOH   A O   1 
HETATM 4873 O  O   . HOH   L 9 .   ? -17.989 -62.421 -2.975  1.00 24.64  ? 1166 HOH   A O   1 
HETATM 4874 O  O   . HOH   L 9 .   ? -36.903 -50.548 -5.410  1.00 34.26  ? 1167 HOH   A O   1 
HETATM 4875 O  O   . HOH   L 9 .   ? -13.879 -49.879 -31.799 0.25 30.36  ? 1168 HOH   A O   1 
HETATM 4876 O  O   . HOH   L 9 .   ? -4.000  -57.586 -9.747  1.00 36.98  ? 1169 HOH   A O   1 
HETATM 4877 O  O   . HOH   L 9 .   ? -29.479 -51.203 -30.033 1.00 56.58  ? 1170 HOH   A O   1 
HETATM 4878 O  O   . HOH   L 9 .   ? -24.379 -69.666 -27.766 1.00 44.90  ? 1171 HOH   A O   1 
HETATM 4879 O  O   . HOH   L 9 .   ? -29.726 -33.888 -29.016 1.00 60.03  ? 1172 HOH   A O   1 
HETATM 4880 O  O   . HOH   L 9 .   ? -16.372 -12.046 -29.697 1.00 52.83  ? 1173 HOH   A O   1 
HETATM 4881 O  O   . HOH   L 9 .   ? -5.210  -15.706 -28.539 1.00 44.19  ? 1174 HOH   A O   1 
HETATM 4882 O  O   . HOH   L 9 .   ? -29.302 -18.070 -21.002 1.00 50.06  ? 1175 HOH   A O   1 
HETATM 4883 O  O   . HOH   L 9 .   ? -5.420  -60.618 -0.831  1.00 37.53  ? 1176 HOH   A O   1 
HETATM 4884 O  O   . HOH   L 9 .   ? 10.342  -30.113 -34.568 1.00 46.90  ? 1177 HOH   A O   1 
HETATM 4885 O  O   . HOH   L 9 .   ? -22.600 -66.170 -23.747 1.00 37.89  ? 1178 HOH   A O   1 
HETATM 4886 O  O   . HOH   L 9 .   ? -14.719 -64.255 -0.452  1.00 28.02  ? 1179 HOH   A O   1 
HETATM 4887 O  O   . HOH   L 9 .   ? -35.176 -50.457 -12.945 1.00 42.49  ? 1180 HOH   A O   1 
HETATM 4888 O  O   . HOH   L 9 .   ? -15.033 -35.083 -29.184 1.00 25.09  ? 1181 HOH   A O   1 
HETATM 4889 O  O   . HOH   L 9 .   ? -14.015 -45.400 -3.856  1.00 57.52  ? 1182 HOH   A O   1 
HETATM 4890 O  O   . HOH   L 9 .   ? -16.199 -11.087 -22.727 1.00 64.38  ? 1183 HOH   A O   1 
HETATM 4891 O  O   . HOH   L 9 .   ? 11.503  -37.506 -19.579 1.00 59.43  ? 1184 HOH   A O   1 
HETATM 4892 O  O   . HOH   L 9 .   ? -9.000  -59.331 -13.335 1.00 25.57  ? 1185 HOH   A O   1 
HETATM 4893 O  O   . HOH   L 9 .   ? -11.002 -48.551 -39.229 1.00 28.58  ? 1186 HOH   A O   1 
HETATM 4894 O  O   . HOH   L 9 .   ? 5.715   -32.980 -38.085 1.00 48.54  ? 1187 HOH   A O   1 
HETATM 4895 O  O   . HOH   L 9 .   ? -38.545 -38.194 -26.470 1.00 58.54  ? 1188 HOH   A O   1 
HETATM 4896 O  O   . HOH   L 9 .   ? 5.506   -30.213 -21.937 1.00 33.42  ? 1189 HOH   A O   1 
HETATM 4897 O  O   . HOH   L 9 .   ? -1.822  -60.250 -31.722 1.00 64.94  ? 1190 HOH   A O   1 
HETATM 4898 O  O   . HOH   L 9 .   ? -13.635 -74.571 -14.148 1.00 51.65  ? 1191 HOH   A O   1 
HETATM 4899 O  O   . HOH   L 9 .   ? -29.325 -63.779 -34.648 1.00 55.19  ? 1192 HOH   A O   1 
HETATM 4900 O  O   . HOH   L 9 .   ? -12.844 -42.989 -39.063 1.00 37.26  ? 1193 HOH   A O   1 
HETATM 4901 O  O   . HOH   L 9 .   ? -28.133 -18.601 -35.274 1.00 49.97  ? 1194 HOH   A O   1 
HETATM 4902 O  O   . HOH   L 9 .   ? 0.184   -64.908 -19.480 1.00 47.11  ? 1195 HOH   A O   1 
HETATM 4903 O  O   . HOH   L 9 .   ? -27.522 -52.619 -42.016 1.00 48.37  ? 1196 HOH   A O   1 
HETATM 4904 O  O   . HOH   L 9 .   ? -22.506 -51.307 -9.148  1.00 28.02  ? 1197 HOH   A O   1 
HETATM 4905 O  O   . HOH   L 9 .   ? -17.642 -31.388 -41.884 1.00 50.99  ? 1198 HOH   A O   1 
HETATM 4906 O  O   . HOH   L 9 .   ? -9.235  -40.126 -39.885 1.00 47.50  ? 1199 HOH   A O   1 
HETATM 4907 O  O   . HOH   L 9 .   ? -12.420 -37.166 -39.733 1.00 29.61  ? 1200 HOH   A O   1 
HETATM 4908 O  O   . HOH   L 9 .   ? -9.020  -26.694 -44.744 1.00 39.53  ? 1201 HOH   A O   1 
HETATM 4909 O  O   . HOH   L 9 .   ? -28.024 -23.301 -26.768 1.00 33.37  ? 1202 HOH   A O   1 
HETATM 4910 O  O   . HOH   L 9 .   ? 10.889  -40.544 -37.791 1.00 60.74  ? 1203 HOH   A O   1 
HETATM 4911 O  O   . HOH   L 9 .   ? -4.370  -65.760 -15.233 1.00 37.97  ? 1204 HOH   A O   1 
HETATM 4912 O  O   . HOH   L 9 .   ? -21.709 -66.319 -4.550  1.00 42.58  ? 1205 HOH   A O   1 
HETATM 4913 O  O   . HOH   L 9 .   ? -5.150  -34.601 -21.083 1.00 55.24  ? 1206 HOH   A O   1 
HETATM 4914 O  O   . HOH   L 9 .   ? -0.762  -11.152 -30.420 1.00 52.28  ? 1207 HOH   A O   1 
HETATM 4915 O  O   . HOH   L 9 .   ? -3.380  -20.299 -23.729 1.00 39.90  ? 1208 HOH   A O   1 
HETATM 4916 O  O   . HOH   L 9 .   ? -0.057  -31.390 -23.316 1.00 32.76  ? 1209 HOH   A O   1 
HETATM 4917 O  O   . HOH   L 9 .   ? 6.019   -31.421 -19.604 1.00 42.55  ? 1210 HOH   A O   1 
HETATM 4918 O  O   . HOH   L 9 .   ? -9.545  -21.623 -27.397 1.00 37.13  ? 1211 HOH   A O   1 
HETATM 4919 O  O   . HOH   L 9 .   ? -17.457 -62.181 -44.858 1.00 51.59  ? 1212 HOH   A O   1 
HETATM 4920 O  O   . HOH   L 9 .   ? 2.719   -39.653 -27.173 1.00 33.46  ? 1213 HOH   A O   1 
HETATM 4921 O  O   . HOH   L 9 .   ? -32.779 -63.873 -15.119 1.00 27.52  ? 1214 HOH   A O   1 
HETATM 4922 O  O   . HOH   L 9 .   ? -35.604 -66.861 -0.719  1.00 35.39  ? 1215 HOH   A O   1 
HETATM 4923 O  O   . HOH   L 9 .   ? -10.057 -75.494 -8.814  1.00 59.92  ? 1216 HOH   A O   1 
HETATM 4924 O  O   . HOH   L 9 .   ? -39.953 -24.114 -26.632 1.00 47.79  ? 1217 HOH   A O   1 
HETATM 4925 O  O   . HOH   L 9 .   ? -32.606 -49.181 -18.837 1.00 46.98  ? 1218 HOH   A O   1 
HETATM 4926 O  O   . HOH   L 9 .   ? -24.862 -14.627 -4.957  1.00 55.15  ? 1219 HOH   A O   1 
HETATM 4927 O  O   . HOH   L 9 .   ? -31.780 -60.326 -15.876 1.00 29.16  ? 1220 HOH   A O   1 
HETATM 4928 O  O   . HOH   L 9 .   ? 4.047   -26.775 -29.690 1.00 37.12  ? 1221 HOH   A O   1 
HETATM 4929 O  O   . HOH   L 9 .   ? -7.183  -50.023 -6.716  1.00 47.27  ? 1222 HOH   A O   1 
HETATM 4930 O  O   . HOH   L 9 .   ? -19.347 -17.269 -11.518 1.00 47.85  ? 1223 HOH   A O   1 
HETATM 4931 O  O   . HOH   L 9 .   ? -34.815 -63.032 0.647   1.00 24.34  ? 1224 HOH   A O   1 
HETATM 4932 O  O   . HOH   L 9 .   ? -4.656  -62.534 -4.675  1.00 41.95  ? 1225 HOH   A O   1 
HETATM 4933 O  O   . HOH   L 9 .   ? -29.861 -59.802 -19.730 1.00 38.87  ? 1226 HOH   A O   1 
HETATM 4934 O  O   . HOH   L 9 .   ? -3.075  -55.369 -18.106 1.00 28.31  ? 1227 HOH   A O   1 
HETATM 4935 O  O   . HOH   L 9 .   ? 7.847   -43.194 -36.283 1.00 51.56  ? 1228 HOH   A O   1 
HETATM 4936 O  O   . HOH   L 9 .   ? 8.238   -45.040 -29.345 1.00 58.06  ? 1229 HOH   A O   1 
HETATM 4937 O  O   . HOH   L 9 .   ? -28.039 -47.402 -0.007  1.00 42.27  ? 1230 HOH   A O   1 
HETATM 4938 O  O   . HOH   L 9 .   ? -23.219 -27.761 -24.860 1.00 41.00  ? 1231 HOH   A O   1 
HETATM 4939 O  O   . HOH   L 9 .   ? -41.246 -58.428 -9.892  0.50 29.54  ? 1232 HOH   A O   1 
HETATM 4940 O  O   . HOH   L 9 .   ? -5.276  -48.924 -28.790 1.00 28.34  ? 1233 HOH   A O   1 
HETATM 4941 O  O   . HOH   L 9 .   ? -28.440 -50.211 0.187   1.00 31.35  ? 1234 HOH   A O   1 
HETATM 4942 O  O   . HOH   L 9 .   ? -35.929 -57.674 -30.784 1.00 62.28  ? 1235 HOH   A O   1 
HETATM 4943 O  O   . HOH   L 9 .   ? -15.071 -17.395 -36.258 1.00 37.01  ? 1236 HOH   A O   1 
HETATM 4944 O  O   . HOH   L 9 .   ? -30.284 -57.234 -34.326 1.00 40.19  ? 1237 HOH   A O   1 
HETATM 4945 O  O   . HOH   L 9 .   ? -26.627 -30.970 -23.554 1.00 52.28  ? 1238 HOH   A O   1 
HETATM 4946 O  O   . HOH   L 9 .   ? -26.137 -50.767 -3.921  0.25 24.69  ? 1239 HOH   A O   1 
HETATM 4947 O  O   . HOH   L 9 .   ? -16.402 -67.013 -20.796 1.00 40.67  ? 1240 HOH   A O   1 
HETATM 4948 O  O   . HOH   L 9 .   ? -18.818 -65.484 -7.168  1.00 20.55  ? 1241 HOH   A O   1 
HETATM 4949 O  O   . HOH   L 9 .   ? -15.366 -66.275 -33.790 1.00 49.13  ? 1242 HOH   A O   1 
HETATM 4950 O  O   . HOH   L 9 .   ? 2.799   -64.780 -20.905 1.00 23.63  ? 1243 HOH   A O   1 
HETATM 4951 O  O   . HOH   L 9 .   ? 3.115   -44.926 -40.015 0.50 42.55  ? 1244 HOH   A O   1 
HETATM 4952 O  O   . HOH   L 9 .   ? -21.000 -19.878 -39.094 1.00 54.08  ? 1245 HOH   A O   1 
HETATM 4953 O  O   . HOH   L 9 .   ? -22.268 -74.530 -11.627 1.00 28.76  ? 1246 HOH   A O   1 
HETATM 4954 O  O   . HOH   L 9 .   ? -38.862 -55.291 -18.969 1.00 42.79  ? 1247 HOH   A O   1 
HETATM 4955 O  O   . HOH   L 9 .   ? -5.890  -50.569 -18.680 1.00 33.13  ? 1248 HOH   A O   1 
HETATM 4956 O  O   . HOH   L 9 .   ? -26.521 -71.567 -3.502  1.00 36.78  ? 1249 HOH   A O   1 
HETATM 4957 O  O   . HOH   L 9 .   ? -8.680  -27.709 -46.799 1.00 55.87  ? 1250 HOH   A O   1 
HETATM 4958 O  O   . HOH   L 9 .   ? 0.888   -21.889 -46.043 1.00 55.13  ? 1251 HOH   A O   1 
HETATM 4959 O  O   . HOH   L 9 .   ? -39.681 -55.510 -6.254  1.00 43.71  ? 1252 HOH   A O   1 
HETATM 4960 O  O   . HOH   L 9 .   ? -28.929 -45.988 2.618   1.00 43.01  ? 1253 HOH   A O   1 
HETATM 4961 O  O   . HOH   L 9 .   ? -5.723  -59.429 -12.197 1.00 46.69  ? 1254 HOH   A O   1 
HETATM 4962 O  O   . HOH   L 9 .   ? -12.465 -46.188 -10.515 0.25 48.99  ? 1255 HOH   A O   1 
HETATM 4963 O  O   . HOH   L 9 .   ? -27.259 -57.424 -39.991 1.00 47.35  ? 1256 HOH   A O   1 
HETATM 4964 O  O   . HOH   L 9 .   ? -5.609  -33.143 -17.713 1.00 40.47  ? 1257 HOH   A O   1 
HETATM 4965 O  O   . HOH   L 9 .   ? 7.719   -22.178 -24.881 1.00 43.21  ? 1258 HOH   A O   1 
HETATM 4966 O  O   . HOH   L 9 .   ? -17.840 -66.286 -36.256 1.00 47.06  ? 1259 HOH   A O   1 
HETATM 4967 O  O   . HOH   L 9 .   ? -20.659 -66.411 -1.328  1.00 32.11  ? 1260 HOH   A O   1 
HETATM 4968 O  O   . HOH   L 9 .   ? -19.101 -70.028 -8.218  1.00 26.59  ? 1261 HOH   A O   1 
HETATM 4969 O  O   . HOH   L 9 .   ? -0.265  -55.641 -32.987 1.00 52.92  ? 1262 HOH   A O   1 
HETATM 4970 O  O   . HOH   L 9 .   ? -8.461  -72.327 -20.495 1.00 61.60  ? 1263 HOH   A O   1 
HETATM 4971 O  O   . HOH   L 9 .   ? -20.984 -65.724 -41.041 1.00 40.38  ? 1264 HOH   A O   1 
HETATM 4972 O  O   . HOH   L 9 .   ? 8.622   -24.268 -36.313 1.00 59.72  ? 1265 HOH   A O   1 
HETATM 4973 O  O   . HOH   L 9 .   ? 4.871   -37.044 -23.730 0.50 22.53  ? 1266 HOH   A O   1 
HETATM 4974 O  O   . HOH   L 9 .   ? -33.904 -70.437 -18.344 1.00 39.55  ? 1267 HOH   A O   1 
HETATM 4975 O  O   . HOH   L 9 .   ? 1.185   -41.792 -24.644 1.00 43.15  ? 1268 HOH   A O   1 
HETATM 4976 O  O   . HOH   L 9 .   ? -33.673 -57.835 -19.674 1.00 43.10  ? 1269 HOH   A O   1 
HETATM 4977 O  O   . HOH   L 9 .   ? -36.287 -58.519 -20.796 1.00 49.25  ? 1270 HOH   A O   1 
HETATM 4978 O  O   . HOH   L 9 .   ? -21.007 -31.981 -29.539 1.00 30.87  ? 1271 HOH   A O   1 
HETATM 4979 O  O   . HOH   L 9 .   ? -31.350 -45.379 -15.404 1.00 52.80  ? 1272 HOH   A O   1 
HETATM 4980 O  O   . HOH   L 9 .   ? -17.276 -29.013 -41.162 1.00 55.24  ? 1273 HOH   A O   1 
HETATM 4981 O  O   . HOH   L 9 .   ? 4.012   -29.104 -44.644 1.00 42.76  ? 1274 HOH   A O   1 
HETATM 4982 O  O   . HOH   L 9 .   ? -13.226 -68.800 -6.162  1.00 37.30  ? 1275 HOH   A O   1 
HETATM 4983 O  O   . HOH   L 9 .   ? 0.472   -23.564 -17.241 1.00 57.67  ? 1276 HOH   A O   1 
HETATM 4984 O  O   . HOH   L 9 .   ? -8.880  -71.252 -14.561 1.00 37.37  ? 1277 HOH   A O   1 
HETATM 4985 O  O   . HOH   L 9 .   ? -13.683 -53.846 -1.560  1.00 25.67  ? 1278 HOH   A O   1 
HETATM 4986 O  O   . HOH   L 9 .   ? -23.196 -33.775 -36.991 1.00 34.33  ? 1279 HOH   A O   1 
HETATM 4987 O  O   . HOH   L 9 .   ? -27.493 -15.945 -20.145 1.00 52.06  ? 1280 HOH   A O   1 
HETATM 4988 O  O   . HOH   L 9 .   ? 8.412   -40.720 -31.931 1.00 55.44  ? 1281 HOH   A O   1 
HETATM 4989 O  O   . HOH   L 9 .   ? 10.519  -27.035 -29.288 1.00 48.54  ? 1282 HOH   A O   1 
HETATM 4990 O  O   . HOH   L 9 .   ? -39.920 -54.821 -14.839 1.00 43.25  ? 1283 HOH   A O   1 
HETATM 4991 O  O   . HOH   L 9 .   ? -4.358  -23.450 -25.549 1.00 40.88  ? 1284 HOH   A O   1 
HETATM 4992 O  O   . HOH   L 9 .   ? -30.119 -61.094 -23.107 1.00 32.90  ? 1285 HOH   A O   1 
HETATM 4993 O  O   . HOH   L 9 .   ? -17.072 -52.150 -15.576 1.00 21.98  ? 1286 HOH   A O   1 
HETATM 4994 O  O   . HOH   L 9 .   ? 1.218   -38.589 -21.645 0.50 28.94  ? 1287 HOH   A O   1 
HETATM 4995 O  O   . HOH   L 9 .   ? -1.201  -68.763 -21.558 1.00 51.31  ? 1288 HOH   A O   1 
HETATM 4996 O  O   . HOH   L 9 .   ? -20.563 -67.611 -25.312 1.00 28.12  ? 1289 HOH   A O   1 
HETATM 4997 O  O   . HOH   L 9 .   ? -19.977 -76.398 -14.328 1.00 60.56  ? 1290 HOH   A O   1 
HETATM 4998 O  O   . HOH   L 9 .   ? -14.161 -52.427 -5.897  1.00 25.17  ? 1291 HOH   A O   1 
HETATM 4999 O  O   . HOH   L 9 .   ? -12.199 -44.388 -16.479 1.00 51.69  ? 1292 HOH   A O   1 
HETATM 5000 O  O   . HOH   L 9 .   ? -10.628 -41.680 -38.003 1.00 43.56  ? 1293 HOH   A O   1 
HETATM 5001 O  O   . HOH   L 9 .   ? -14.796 -68.710 -19.733 1.00 42.96  ? 1294 HOH   A O   1 
HETATM 5002 O  O   . HOH   L 9 .   ? -14.268 -56.693 -1.509  1.00 22.25  ? 1295 HOH   A O   1 
HETATM 5003 O  O   . HOH   L 9 .   ? -35.859 -54.458 -3.281  1.00 34.32  ? 1296 HOH   A O   1 
HETATM 5004 O  O   . HOH   L 9 .   ? -25.048 -53.653 -1.882  1.00 24.98  ? 1297 HOH   A O   1 
HETATM 5005 O  O   . HOH   L 9 .   ? -24.520 -70.110 -34.190 1.00 65.85  ? 1298 HOH   A O   1 
HETATM 5006 O  O   . HOH   L 9 .   ? -39.772 -64.408 -2.222  1.00 46.98  ? 1299 HOH   A O   1 
HETATM 5007 O  O   . HOH   L 9 .   ? -0.596  -35.837 -28.347 1.00 32.96  ? 1300 HOH   A O   1 
HETATM 5008 O  O   . HOH   L 9 .   ? -35.628 -58.914 -27.278 1.00 51.02  ? 1301 HOH   A O   1 
HETATM 5009 O  O   . HOH   L 9 .   ? -20.205 -38.274 -36.799 1.00 32.80  ? 1302 HOH   A O   1 
HETATM 5010 O  O   . HOH   L 9 .   ? -22.856 -27.837 -19.042 1.00 50.73  ? 1303 HOH   A O   1 
HETATM 5011 O  O   . HOH   L 9 .   ? -14.909 -70.842 -18.709 1.00 47.81  ? 1304 HOH   A O   1 
HETATM 5012 O  O   . HOH   L 9 .   ? -34.884 -59.850 -29.575 1.00 52.87  ? 1305 HOH   A O   1 
HETATM 5013 O  O   . HOH   L 9 .   ? -31.170 -74.144 -18.050 1.00 63.45  ? 1306 HOH   A O   1 
HETATM 5014 O  O   . HOH   L 9 .   ? -4.858  -56.569 -31.622 1.00 28.24  ? 1307 HOH   A O   1 
HETATM 5015 O  O   . HOH   L 9 .   ? -24.395 -69.136 -38.180 1.00 51.17  ? 1308 HOH   A O   1 
HETATM 5016 O  O   . HOH   L 9 .   ? -4.100  -57.395 -13.414 1.00 46.47  ? 1309 HOH   A O   1 
HETATM 5017 O  O   . HOH   L 9 .   ? -23.414 -50.076 -42.114 1.00 42.43  ? 1310 HOH   A O   1 
HETATM 5018 O  O   . HOH   L 9 .   ? 6.550   -29.449 -44.075 1.00 47.70  ? 1311 HOH   A O   1 
HETATM 5019 O  O   . HOH   L 9 .   ? -5.934  -49.315 -21.312 1.00 30.43  ? 1312 HOH   A O   1 
HETATM 5020 O  O   . HOH   L 9 .   ? -19.138 -68.598 -1.911  1.00 43.16  ? 1313 HOH   A O   1 
HETATM 5021 O  O   . HOH   L 9 .   ? -37.655 -52.698 -13.037 1.00 30.51  ? 1314 HOH   A O   1 
HETATM 5022 O  O   . HOH   L 9 .   ? -5.377  -58.646 -29.979 1.00 43.20  ? 1315 HOH   A O   1 
HETATM 5023 O  O   . HOH   L 9 .   ? 7.313   -49.886 -30.564 1.00 53.27  ? 1316 HOH   A O   1 
HETATM 5024 O  O   . HOH   L 9 .   ? 3.336   -31.631 -37.524 1.00 29.69  ? 1317 HOH   A O   1 
HETATM 5025 O  O   . HOH   L 9 .   ? -29.935 -61.820 -33.130 1.00 47.75  ? 1318 HOH   A O   1 
HETATM 5026 O  O   . HOH   L 9 .   ? -5.486  -74.365 -13.105 0.42 45.16  ? 1319 HOH   A O   1 
HETATM 5027 O  O   . HOH   L 9 .   ? -23.471 -48.213 -33.750 1.00 56.05  ? 1320 HOH   A O   1 
HETATM 5028 O  O   . HOH   L 9 .   ? -28.082 -17.019 -32.582 1.00 44.19  ? 1321 HOH   A O   1 
HETATM 5029 O  O   . HOH   L 9 .   ? -7.314  -57.681 -1.135  1.00 48.00  ? 1322 HOH   A O   1 
HETATM 5030 O  O   . HOH   L 9 .   ? -15.119 -48.833 -18.753 1.00 35.06  ? 1323 HOH   A O   1 
HETATM 5031 O  O   . HOH   L 9 .   ? -27.338 -26.988 -36.004 1.00 32.11  ? 1324 HOH   A O   1 
HETATM 5032 O  O   . HOH   L 9 .   ? -32.074 -19.287 -31.131 1.00 51.97  ? 1325 HOH   A O   1 
HETATM 5033 O  O   . HOH   L 9 .   ? -27.362 -9.142  -30.712 1.00 59.93  ? 1326 HOH   A O   1 
HETATM 5034 O  O   . HOH   L 9 .   ? -31.305 -71.936 -13.553 1.00 57.50  ? 1327 HOH   A O   1 
HETATM 5035 O  O   . HOH   L 9 .   ? -35.373 -59.508 -0.520  1.00 46.51  ? 1328 HOH   A O   1 
HETATM 5036 O  O   . HOH   L 9 .   ? -14.534 -21.203 -17.147 1.00 46.93  ? 1329 HOH   A O   1 
HETATM 5037 O  O   . HOH   L 9 .   ? -6.507  -37.172 -20.662 1.00 51.75  ? 1330 HOH   A O   1 
HETATM 5038 O  O   . HOH   L 9 .   ? -3.025  -58.370 -24.673 1.00 24.38  ? 1331 HOH   A O   1 
HETATM 5039 O  O   . HOH   L 9 .   ? -26.662 -44.972 -18.605 0.25 50.15  ? 1332 HOH   A O   1 
HETATM 5040 O  O   . HOH   L 9 .   ? -2.121  -70.521 -17.949 1.00 49.47  ? 1333 HOH   A O   1 
HETATM 5041 O  O   . HOH   L 9 .   ? -8.736  -17.244 -39.583 1.00 46.43  ? 1334 HOH   A O   1 
HETATM 5042 O  O   . HOH   L 9 .   ? -7.897  -30.239 -46.267 1.00 41.86  ? 1335 HOH   A O   1 
HETATM 5043 O  O   . HOH   L 9 .   ? -2.582  -58.232 -27.510 1.00 26.36  ? 1336 HOH   A O   1 
HETATM 5044 O  O   . HOH   L 9 .   ? -9.748  -70.667 -22.399 1.00 47.85  ? 1337 HOH   A O   1 
HETATM 5045 O  O   . HOH   L 9 .   ? -23.149 -20.956 -37.883 1.00 45.09  ? 1338 HOH   A O   1 
HETATM 5046 O  O   . HOH   L 9 .   ? -15.551 -55.440 -43.643 1.00 48.72  ? 1339 HOH   A O   1 
HETATM 5047 O  O   . HOH   L 9 .   ? -3.748  -71.086 -9.105  1.00 42.08  ? 1340 HOH   A O   1 
HETATM 5048 O  O   . HOH   L 9 .   ? -20.327 -70.986 -5.846  1.00 43.55  ? 1341 HOH   A O   1 
HETATM 5049 O  O   . HOH   L 9 .   ? -12.424 -67.363 -29.574 1.00 38.34  ? 1342 HOH   A O   1 
HETATM 5050 O  O   . HOH   L 9 .   ? -5.898  -69.248 -7.288  1.00 35.94  ? 1343 HOH   A O   1 
HETATM 5051 O  O   . HOH   L 9 .   ? -6.274  -43.380 -21.486 1.00 52.37  ? 1344 HOH   A O   1 
HETATM 5052 O  O   . HOH   L 9 .   ? -20.359 -31.657 -26.779 1.00 32.28  ? 1345 HOH   A O   1 
HETATM 5053 O  O   . HOH   L 9 .   ? -5.878  -68.765 -27.443 1.00 31.22  ? 1346 HOH   A O   1 
HETATM 5054 O  O   . HOH   L 9 .   ? -35.683 -51.090 -23.232 1.00 56.04  ? 1347 HOH   A O   1 
HETATM 5055 O  O   . HOH   L 9 .   ? -10.765 -17.858 -40.773 1.00 50.36  ? 1348 HOH   A O   1 
HETATM 5056 O  O   . HOH   L 9 .   ? -17.295 -57.912 -43.684 1.00 36.74  ? 1349 HOH   A O   1 
HETATM 5057 O  O   . HOH   L 9 .   ? -22.985 -75.600 -9.124  1.00 42.88  ? 1350 HOH   A O   1 
HETATM 5058 O  O   . HOH   L 9 .   ? -18.216 -69.578 -24.748 1.00 39.11  ? 1351 HOH   A O   1 
HETATM 5059 O  O   . HOH   L 9 .   ? -2.424  -39.882 -45.918 1.00 43.41  ? 1352 HOH   A O   1 
HETATM 5060 O  O   . HOH   L 9 .   ? -33.824 -47.342 -15.721 1.00 60.67  ? 1353 HOH   A O   1 
HETATM 5061 O  O   . HOH   L 9 .   ? -3.803  -56.798 -7.086  1.00 33.30  ? 1354 HOH   A O   1 
HETATM 5062 O  O   . HOH   L 9 .   ? -7.531  -62.081 -33.939 0.28 18.82  ? 1355 HOH   A O   1 
HETATM 5063 O  O   . HOH   L 9 .   ? -14.704 -70.379 -3.257  1.00 51.24  ? 1356 HOH   A O   1 
HETATM 5064 O  O   . HOH   L 9 .   ? 9.757   -38.324 -39.653 1.00 45.06  ? 1357 HOH   A O   1 
HETATM 5065 O  O   . HOH   L 9 .   ? -11.735 -72.147 -15.602 1.00 24.55  ? 1358 HOH   A O   1 
HETATM 5066 O  O   . HOH   L 9 .   ? -14.782 -54.414 -4.062  1.00 24.03  ? 1359 HOH   A O   1 
HETATM 5067 O  O   . HOH   L 9 .   ? -11.715 -40.155 -39.660 1.00 61.10  ? 1360 HOH   A O   1 
HETATM 5068 O  O   . HOH   L 9 .   ? -8.521  -31.132 -15.379 1.00 52.88  ? 1361 HOH   A O   1 
HETATM 5069 O  O   . HOH   L 9 .   ? -0.158  -48.305 -36.493 1.00 33.40  ? 1362 HOH   A O   1 
HETATM 5070 O  O   . HOH   L 9 .   ? 13.332  -30.575 -19.860 1.00 44.36  ? 1363 HOH   A O   1 
HETATM 5071 O  O   . HOH   L 9 .   ? -7.514  -30.095 -13.509 1.00 56.31  ? 1364 HOH   A O   1 
HETATM 5072 O  O   . HOH   L 9 .   ? -8.828  -36.108 -45.116 1.00 54.41  ? 1365 HOH   A O   1 
HETATM 5073 O  O   . HOH   L 9 .   ? -14.795 -57.485 -41.956 1.00 30.71  ? 1366 HOH   A O   1 
HETATM 5074 O  O   . HOH   L 9 .   ? -5.738  -58.971 -37.084 1.00 54.85  ? 1367 HOH   A O   1 
HETATM 5075 O  O   . HOH   L 9 .   ? 0.696   -31.470 -47.261 1.00 43.28  ? 1368 HOH   A O   1 
HETATM 5076 O  O   . HOH   L 9 .   ? -28.299 -49.426 -31.707 1.00 49.98  ? 1369 HOH   A O   1 
HETATM 5077 O  O   . HOH   L 9 .   ? -24.790 -31.041 -40.186 1.00 57.26  ? 1370 HOH   A O   1 
HETATM 5078 O  O   . HOH   L 9 .   ? -18.836 -49.792 -35.229 1.00 43.16  ? 1371 HOH   A O   1 
HETATM 5079 O  O   . HOH   L 9 .   ? -21.473 -41.902 -35.274 1.00 55.57  ? 1372 HOH   A O   1 
HETATM 5080 O  O   . HOH   L 9 .   ? -17.601 -71.661 -22.728 1.00 52.99  ? 1373 HOH   A O   1 
HETATM 5081 O  O   . HOH   L 9 .   ? -20.897 -75.784 -5.467  1.00 53.63  ? 1374 HOH   A O   1 
HETATM 5082 O  O   . HOH   L 9 .   ? -11.110 -46.635 4.033   1.00 41.18  ? 1375 HOH   A O   1 
HETATM 5083 O  O   . HOH   L 9 .   ? 14.750  -32.656 -32.043 0.28 29.74  ? 1376 HOH   A O   1 
HETATM 5084 O  O   . HOH   L 9 .   ? -0.985  -32.604 -25.673 1.00 31.90  ? 1377 HOH   A O   1 
HETATM 5085 O  O   . HOH   L 9 .   ? -13.654 -51.393 -43.262 1.00 55.86  ? 1378 HOH   A O   1 
HETATM 5086 O  O   . HOH   L 9 .   ? -19.242 -64.794 -3.022  1.00 35.81  ? 1379 HOH   A O   1 
HETATM 5087 O  O   . HOH   L 9 .   ? -26.620 -68.033 -27.910 1.00 31.53  ? 1380 HOH   A O   1 
HETATM 5088 O  O   . HOH   L 9 .   ? -4.630  -53.042 -38.779 1.00 60.31  ? 1381 HOH   A O   1 
HETATM 5089 O  O   . HOH   L 9 .   ? -5.926  -40.165 -45.659 1.00 68.60  ? 1382 HOH   A O   1 
HETATM 5090 O  O   . HOH   L 9 .   ? -28.742 -63.214 -25.336 1.00 37.63  ? 1383 HOH   A O   1 
HETATM 5091 O  O   . HOH   L 9 .   ? -35.058 -67.914 -5.471  1.00 47.95  ? 1384 HOH   A O   1 
HETATM 5092 O  O   . HOH   L 9 .   ? -21.561 -44.056 -42.266 1.00 63.56  ? 1385 HOH   A O   1 
HETATM 5093 O  O   . HOH   L 9 .   ? -19.354 -14.745 -38.219 1.00 66.41  ? 1386 HOH   A O   1 
HETATM 5094 O  O   . HOH   L 9 .   ? -12.566 -38.073 -22.536 1.00 53.01  ? 1387 HOH   A O   1 
HETATM 5095 O  O   . HOH   L 9 .   ? -19.860 -45.526 -24.611 0.25 16.39  ? 1388 HOH   A O   1 
HETATM 5096 O  O   . HOH   L 9 .   ? -9.652  -67.174 -28.701 0.28 17.78  ? 1389 HOH   A O   1 
HETATM 5097 O  O   . HOH   L 9 .   ? -13.250 -11.780 -33.157 1.00 59.63  ? 1390 HOH   A O   1 
HETATM 5098 O  O   . HOH   L 9 .   ? -37.541 -68.740 -12.445 1.00 48.52  ? 1391 HOH   A O   1 
HETATM 5099 O  O   . HOH   L 9 .   ? -38.359 -28.309 -27.210 1.00 48.34  ? 1392 HOH   A O   1 
HETATM 5100 O  O   . HOH   L 9 .   ? -13.439 -32.748 -20.623 1.00 37.85  ? 1393 HOH   A O   1 
HETATM 5101 O  O   . HOH   L 9 .   ? 3.520   -33.924 -14.514 1.00 57.08  ? 1394 HOH   A O   1 
HETATM 5102 O  O   . HOH   L 9 .   ? -3.263  -72.928 -6.693  1.00 64.30  ? 1395 HOH   A O   1 
HETATM 5103 O  O   . HOH   L 9 .   ? -10.107 -25.756 -12.601 1.00 53.78  ? 1396 HOH   A O   1 
HETATM 5104 O  O   . HOH   L 9 .   ? -6.812  -61.264 -30.230 0.28 21.57  ? 1397 HOH   A O   1 
HETATM 5105 O  O   . HOH   L 9 .   ? -4.272  -34.556 -14.482 1.00 49.59  ? 1398 HOH   A O   1 
HETATM 5106 O  O   . HOH   L 9 .   ? 0.012   -45.943 -42.965 1.00 51.52  ? 1399 HOH   A O   1 
HETATM 5107 O  O   . HOH   L 9 .   ? -26.549 -28.116 -42.966 1.00 54.59  ? 1400 HOH   A O   1 
HETATM 5108 O  O   . HOH   L 9 .   ? -23.378 -45.596 -9.165  1.00 52.68  ? 1401 HOH   A O   1 
HETATM 5109 O  O   . HOH   L 9 .   ? 0.364   -45.813 -37.071 1.00 52.69  ? 1402 HOH   A O   1 
HETATM 5110 O  O   . HOH   L 9 .   ? -33.672 -70.322 -14.439 1.00 54.05  ? 1403 HOH   A O   1 
HETATM 5111 O  O   . HOH   L 9 .   ? 4.399   -62.735 -20.270 1.00 23.11  ? 1404 HOH   A O   1 
HETATM 5112 O  O   . HOH   L 9 .   ? -22.183 -31.686 -39.876 1.00 42.56  ? 1405 HOH   A O   1 
HETATM 5113 O  O   . HOH   L 9 .   ? -23.011 -63.301 -23.560 1.00 49.65  ? 1406 HOH   A O   1 
HETATM 5114 O  O   . HOH   L 9 .   ? 0.553   -70.860 -21.416 1.00 44.33  ? 1407 HOH   A O   1 
HETATM 5115 O  O   . HOH   L 9 .   ? -7.370  -51.444 -10.545 1.00 53.32  ? 1408 HOH   A O   1 
HETATM 5116 O  O   . HOH   L 9 .   ? -12.435 -76.039 -27.041 1.00 61.83  ? 1409 HOH   A O   1 
HETATM 5117 O  O   . HOH   L 9 .   ? -10.080 -28.166 -11.984 1.00 55.29  ? 1410 HOH   A O   1 
HETATM 5118 O  O   . HOH   L 9 .   ? -9.159  -55.579 -41.601 1.00 58.83  ? 1411 HOH   A O   1 
HETATM 5119 O  O   . HOH   L 9 .   ? -12.433 -70.375 -23.171 1.00 52.95  ? 1412 HOH   A O   1 
HETATM 5120 O  O   . HOH   L 9 .   ? 6.098   -39.624 -23.624 0.50 52.63  ? 1413 HOH   A O   1 
HETATM 5121 O  O   . HOH   L 9 .   ? -40.984 -25.365 -17.938 0.25 61.40  ? 1414 HOH   A O   1 
HETATM 5122 O  O   . HOH   L 9 .   ? -4.849  -47.315 -21.762 1.00 42.41  ? 1415 HOH   A O   1 
HETATM 5123 O  O   . HOH   L 9 .   ? -23.250 -37.398 -32.947 1.00 57.70  ? 1416 HOH   A O   1 
HETATM 5124 O  O   . HOH   L 9 .   ? -36.561 -61.131 -20.607 1.00 56.23  ? 1417 HOH   A O   1 
HETATM 5125 O  O   . HOH   L 9 .   ? -19.628 -43.994 -38.150 1.00 58.35  ? 1418 HOH   A O   1 
HETATM 5126 O  O   . HOH   L 9 .   ? -2.908  -55.885 -28.827 1.00 27.26  ? 1419 HOH   A O   1 
HETATM 5127 O  O   . HOH   L 9 .   ? -34.191 -49.735 -10.374 1.00 46.35  ? 1420 HOH   A O   1 
HETATM 5128 O  O   . HOH   L 9 .   ? 3.863   -41.425 -24.130 0.50 32.66  ? 1421 HOH   A O   1 
HETATM 5129 O  O   . HOH   L 9 .   ? -29.325 -69.687 -39.676 0.50 41.61  ? 1422 HOH   A O   1 
HETATM 5130 O  O   . HOH   L 9 .   ? 16.492  -34.261 -27.012 1.00 55.44  ? 1423 HOH   A O   1 
HETATM 5131 O  O   . HOH   L 9 .   ? 0.000   -58.428 -16.519 0.50 52.29  ? 1424 HOH   A O   1 
HETATM 5132 O  O   . HOH   L 9 .   ? -30.260 -33.894 -33.018 1.00 62.80  ? 1425 HOH   A O   1 
HETATM 5133 O  O   . HOH   L 9 .   ? -17.822 -28.020 -44.638 1.00 54.99  ? 1426 HOH   A O   1 
HETATM 5134 O  O   . HOH   L 9 .   ? -34.660 -70.296 -9.519  1.00 59.50  ? 1427 HOH   A O   1 
HETATM 5135 O  O   . HOH   L 9 .   ? -23.429 -59.474 -47.400 0.50 48.25  ? 1428 HOH   A O   1 
HETATM 5136 O  O   . HOH   L 9 .   ? 6.419   -40.505 -21.503 0.50 48.09  ? 1429 HOH   A O   1 
HETATM 5137 O  O   . HOH   L 9 .   ? 0.000   -58.428 -28.570 0.50 32.09  ? 1430 HOH   A O   1 
HETATM 5138 O  O   . HOH   L 9 .   ? -27.602 -40.636 -5.464  1.00 59.75  ? 1431 HOH   A O   1 
HETATM 5139 O  O   . HOH   L 9 .   ? -16.141 -49.818 -16.417 0.25 16.89  ? 1432 HOH   A O   1 
HETATM 5140 O  O   . HOH   L 9 .   ? 5.396   -45.479 -26.159 1.00 43.14  ? 1433 HOH   A O   1 
HETATM 5141 O  O   . HOH   L 9 .   ? -5.689  -31.388 -48.065 1.00 56.62  ? 1434 HOH   A O   1 
HETATM 5142 O  O   . HOH   L 9 .   ? -32.024 -13.289 -9.578  1.00 57.23  ? 1435 HOH   A O   1 
HETATM 5143 O  O   . HOH   L 9 .   ? -9.092  -62.640 -41.833 1.00 59.94  ? 1436 HOH   A O   1 
HETATM 5144 O  O   . HOH   L 9 .   ? -36.794 -65.055 0.133   1.00 43.12  ? 1437 HOH   A O   1 
HETATM 5145 O  O   . HOH   L 9 .   ? -10.297 -38.654 -43.832 1.00 57.84  ? 1438 HOH   A O   1 
HETATM 5146 O  O   . HOH   L 9 .   ? -15.482 -45.887 -11.029 0.25 39.19  ? 1439 HOH   A O   1 
HETATM 5147 O  O   . HOH   L 9 .   ? -42.702 -66.633 -9.500  1.00 57.07  ? 1440 HOH   A O   1 
HETATM 5148 O  O   . HOH   L 9 .   ? -31.002 -16.960 -32.183 1.00 53.33  ? 1441 HOH   A O   1 
HETATM 5149 O  O   . HOH   L 9 .   ? -37.711 -60.706 -0.321  1.00 61.58  ? 1442 HOH   A O   1 
HETATM 5150 O  O   . HOH   L 9 .   ? -15.922 -27.352 -46.097 1.00 57.75  ? 1443 HOH   A O   1 
HETATM 5151 O  O   . HOH   L 9 .   ? 8.810   -43.204 -33.012 1.00 64.77  ? 1444 HOH   A O   1 
HETATM 5152 O  O   . HOH   L 9 .   ? -37.944 -52.471 -4.137  1.00 42.40  ? 1445 HOH   A O   1 
HETATM 5153 O  O   . HOH   L 9 .   ? -25.266 -20.925 -4.987  1.00 53.28  ? 1446 HOH   A O   1 
HETATM 5154 O  O   . HOH   L 9 .   ? -2.642  -51.911 2.274   1.00 62.73  ? 1447 HOH   A O   1 
HETATM 5155 O  O   . HOH   L 9 .   ? -27.211 -74.014 -4.644  1.00 45.19  ? 1448 HOH   A O   1 
HETATM 5156 O  O   . HOH   L 9 .   ? -42.906 -24.034 -17.102 0.25 37.15  ? 1449 HOH   A O   1 
HETATM 5157 O  O   . HOH   L 9 .   ? -3.613  -50.596 -17.836 1.00 54.41  ? 1450 HOH   A O   1 
HETATM 5158 O  O   . HOH   L 9 .   ? -25.794 -19.999 -39.076 1.00 52.80  ? 1451 HOH   A O   1 
HETATM 5159 O  O   . HOH   L 9 .   ? -15.820 -69.402 -5.994  1.00 27.41  ? 1452 HOH   A O   1 
HETATM 5160 O  O   . HOH   L 9 .   ? -19.241 -39.932 -38.588 1.00 48.10  ? 1453 HOH   A O   1 
HETATM 5161 O  O   . HOH   L 9 .   ? -7.369  -62.615 -31.226 0.28 35.71  ? 1454 HOH   A O   1 
HETATM 5162 O  O   . HOH   L 9 .   ? -16.997 -39.247 -40.025 1.00 49.97  ? 1455 HOH   A O   1 
HETATM 5163 O  O   . HOH   L 9 .   ? -25.184 -28.822 -22.877 1.00 49.72  ? 1456 HOH   A O   1 
HETATM 5164 O  O   . HOH   L 9 .   ? -1.774  -65.516 -15.658 1.00 55.37  ? 1457 HOH   A O   1 
HETATM 5165 O  O   . HOH   L 9 .   ? -9.513  -23.925 -3.815  1.00 65.84  ? 1458 HOH   A O   1 
HETATM 5166 O  O   . HOH   L 9 .   ? -35.995 -57.268 -4.184  1.00 56.48  ? 1459 HOH   A O   1 
HETATM 5167 O  O   . HOH   L 9 .   ? -38.813 -51.478 -20.212 1.00 57.77  ? 1460 HOH   A O   1 
HETATM 5168 O  O   . HOH   L 9 .   ? -20.966 -59.982 -48.145 1.00 67.48  ? 1461 HOH   A O   1 
HETATM 5169 O  O   . HOH   L 9 .   ? -1.178  -63.274 -15.627 1.00 48.75  ? 1462 HOH   A O   1 
HETATM 5170 O  O   . HOH   L 9 .   ? -3.115  -52.518 -4.470  1.00 65.71  ? 1463 HOH   A O   1 
HETATM 5171 O  O   . HOH   L 9 .   ? -4.202  -49.867 2.998   1.00 67.73  ? 1464 HOH   A O   1 
HETATM 5172 O  O   . HOH   L 9 .   ? -15.855 -9.372  -34.088 1.00 57.73  ? 1465 HOH   A O   1 
HETATM 5173 O  O   . HOH   L 9 .   ? -30.901 -59.959 -34.520 1.00 52.04  ? 1466 HOH   A O   1 
HETATM 5174 O  O   . HOH   L 9 .   ? -8.363  -76.186 -10.552 1.00 60.17  ? 1467 HOH   A O   1 
HETATM 5175 O  O   . HOH   L 9 .   ? 0.364   -62.699 -17.783 1.00 33.52  ? 1468 HOH   A O   1 
HETATM 5176 O  O   . HOH   L 9 .   ? -4.926  -66.827 -6.072  1.00 62.16  ? 1469 HOH   A O   1 
HETATM 5177 O  O   . HOH   L 9 .   ? -24.203 -36.175 -35.167 1.00 52.50  ? 1470 HOH   A O   1 
HETATM 5178 O  O   . HOH   L 9 .   ? -15.604 -41.944 -38.707 1.00 38.64  ? 1471 HOH   A O   1 
HETATM 5179 O  O   . HOH   L 9 .   ? -41.409 -56.799 -13.680 1.00 37.67  ? 1472 HOH   A O   1 
HETATM 5180 O  O   . HOH   L 9 .   ? -6.805  -45.140 -17.189 1.00 64.11  ? 1473 HOH   A O   1 
HETATM 5181 O  O   . HOH   L 9 .   ? -29.198 -21.686 -42.639 1.00 58.33  ? 1474 HOH   A O   1 
HETATM 5182 O  O   . HOH   L 9 .   ? -5.466  -65.471 -31.321 1.00 52.80  ? 1475 HOH   A O   1 
HETATM 5183 O  O   . HOH   L 9 .   ? -9.663  -40.745 -42.361 1.00 57.37  ? 1476 HOH   A O   1 
HETATM 5184 O  O   . HOH   L 9 .   ? -10.669 -68.514 -36.043 1.00 69.34  ? 1477 HOH   A O   1 
HETATM 5185 O  O   . HOH   L 9 .   ? -23.025 -37.874 -37.502 1.00 50.71  ? 1478 HOH   A O   1 
HETATM 5186 O  O   . HOH   L 9 .   ? -15.687 -45.180 -19.581 0.25 34.56  ? 1479 HOH   A O   1 
HETATM 5187 O  O   . HOH   L 9 .   ? -15.768 -43.964 -22.408 0.25 21.25  ? 1480 HOH   A O   1 
HETATM 5188 O  O   . HOH   L 9 .   ? -25.217 -27.857 -20.119 1.00 54.23  ? 1481 HOH   A O   1 
HETATM 5189 O  O   . HOH   L 9 .   ? -3.061  -60.344 -6.178  1.00 61.16  ? 1482 HOH   A O   1 
HETATM 5190 O  O   . HOH   L 9 .   ? -35.858 -48.237 -14.053 1.00 48.10  ? 1483 HOH   A O   1 
HETATM 5191 O  O   . HOH   L 9 .   ? -28.241 -65.513 -42.446 1.00 47.99  ? 1484 HOH   A O   1 
HETATM 5192 O  O   . HOH   L 9 .   ? -18.232 -68.048 -6.407  1.00 23.62  ? 1485 HOH   A O   1 
HETATM 5193 O  O   . HOH   L 9 .   ? -1.613  -55.844 -6.119  1.00 51.39  ? 1486 HOH   A O   1 
HETATM 5194 O  O   . HOH   L 9 .   ? -1.349  -55.259 -0.877  1.00 45.61  ? 1487 HOH   A O   1 
HETATM 5195 O  O   . HOH   L 9 .   ? -2.902  -56.840 -33.960 1.00 46.43  ? 1488 HOH   A O   1 
HETATM 5196 O  O   . HOH   L 9 .   ? -16.056 -60.301 -45.257 1.00 55.49  ? 1489 HOH   A O   1 
HETATM 5197 O  O   . HOH   L 9 .   ? -5.553  -64.375 -6.567  1.00 37.46  ? 1490 HOH   A O   1 
HETATM 5198 O  O   . HOH   L 9 .   ? -2.839  -59.615 -0.648  1.00 44.37  ? 1491 HOH   A O   1 
HETATM 5199 O  O   . HOH   L 9 .   ? -19.919 -68.477 -4.413  1.00 29.60  ? 1492 HOH   A O   1 
HETATM 5200 O  O   . HOH   L 9 .   ? -18.282 -42.034 -19.690 0.25 24.78  ? 1493 HOH   A O   1 
HETATM 5201 O  O   . HOH   L 9 .   ? 0.595   -43.229 -22.003 1.00 59.53  ? 1494 HOH   A O   1 
HETATM 5202 O  O   . HOH   L 9 .   ? -44.185 -68.260 -16.734 1.00 63.15  ? 1495 HOH   A O   1 
HETATM 5203 O  O   . HOH   L 9 .   ? -25.324 -44.012 -33.494 1.00 61.16  ? 1496 HOH   A O   1 
HETATM 5204 O  O   . HOH   L 9 .   ? 10.025  -20.942 -26.074 1.00 49.98  ? 1497 HOH   A O   1 
HETATM 5205 O  O   . HOH   L 9 .   ? -1.642  -59.363 -3.276  1.00 55.37  ? 1498 HOH   A O   1 
HETATM 5206 O  O   . HOH   L 9 .   ? -4.202  -61.118 -10.439 1.00 54.99  ? 1499 HOH   A O   1 
HETATM 5207 O  O   . HOH   L 9 .   ? -22.581 -41.597 -44.054 1.00 68.79  ? 1500 HOH   A O   1 
HETATM 5208 O  O   . HOH   L 9 .   ? -28.133 -56.157 -45.103 1.00 62.22  ? 1501 HOH   A O   1 
HETATM 5209 O  O   . HOH   L 9 .   ? -10.973 -34.332 -46.590 0.28 30.92  ? 1502 HOH   A O   1 
HETATM 5210 O  O   . HOH   L 9 .   ? -32.128 -19.249 -5.794  1.00 72.53  ? 1503 HOH   A O   1 
HETATM 5211 O  O   . HOH   L 9 .   ? 12.979  -25.649 -27.324 1.00 62.18  ? 1504 HOH   A O   1 
HETATM 5212 O  O   . HOH   L 9 .   ? -42.905 -61.014 -1.811  1.00 65.02  ? 1505 HOH   A O   1 
HETATM 5213 O  O   . HOH   L 9 .   ? -3.963  -63.000 -8.908  1.00 56.07  ? 1506 HOH   A O   1 
# 
