data_7I2D
# 
_entry.id   7I2D 
# 
_audit_conform.dict_name       mmcif_pdbx.dic 
_audit_conform.dict_version    5.403 
_audit_conform.dict_location   http://mmcif.pdb.org/dictionaries/ascii/mmcif_pdbx.dic 
# 
loop_
_database_2.database_id 
_database_2.database_code 
_database_2.pdbx_database_accession 
_database_2.pdbx_DOI 
PDB   7I2D         pdb_00007i2d 10.2210/pdb7i2d/pdb 
WWPDB D_1001408228 ?            ?                   
# 
_pdbx_audit_revision_history.ordinal             1 
_pdbx_audit_revision_history.data_content_type   'Structure model' 
_pdbx_audit_revision_history.major_revision      1 
_pdbx_audit_revision_history.minor_revision      0 
_pdbx_audit_revision_history.revision_date       2025-04-02 
_pdbx_audit_revision_history.part_number         ? 
# 
_pdbx_audit_revision_details.ordinal             1 
_pdbx_audit_revision_details.revision_ordinal    1 
_pdbx_audit_revision_details.data_content_type   'Structure model' 
_pdbx_audit_revision_details.provider            repository 
_pdbx_audit_revision_details.type                'Initial release' 
_pdbx_audit_revision_details.description         ? 
_pdbx_audit_revision_details.details             ? 
# 
_pdbx_database_status.entry_id                        7I2D 
_pdbx_database_status.status_code                     REL 
_pdbx_database_status.status_code_sf                  REL 
_pdbx_database_status.status_code_mr                  ? 
_pdbx_database_status.status_code_cs                  ? 
_pdbx_database_status.recvd_initial_deposition_date   2025-03-06 
_pdbx_database_status.status_code_nmr_data            ? 
_pdbx_database_status.deposit_site                    RCSB 
_pdbx_database_status.process_site                    RCSB 
_pdbx_database_status.SG_entry                        ? 
_pdbx_database_status.pdb_format_compatible           Y 
_pdbx_database_status.methods_development_category    ? 
# 
_pdbx_contact_author.id                 1 
_pdbx_contact_author.email              fr193@cabm.rutgers.edu 
_pdbx_contact_author.name_first         'Francesc Xavier' 
_pdbx_contact_author.name_last          Ruiz 
_pdbx_contact_author.role               'principal investigator/group leader' 
_pdbx_contact_author.identifier_ORCID   0000-0002-0457-0030 
_pdbx_contact_author.name_mi            ? 
# 
loop_
_audit_author.name 
_audit_author.pdbx_ordinal 
_audit_author.identifier_ORCID 
'Aschenbrenner, J.C.' 1  ? 
'Saini, M.'           2  ? 
'Chopra, A.'          3  ? 
'Marples, P.G.'       4  ? 
'Balcomb, B.H.'       5  ? 
'Lithgo, R.M.'        6  ? 
'Fearon, D.'          7  ? 
'von Delft, F.'       8  ? 
'Ruiz, F.X.'          9  ? 
'Arnold, E.'          10 ? 
# 
_citation.id                        primary 
_citation.title                     
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_citation.journal_abbrev            'To Be Published' 
_citation.journal_volume            ? 
_citation.page_first                ? 
_citation.page_last                 ? 
_citation.year                      ? 
_citation.journal_id_ASTM           ? 
_citation.country                   ? 
_citation.journal_id_ISSN           ? 
_citation.journal_id_CSD            0353 
_citation.book_publisher            ? 
_citation.pdbx_database_id_PubMed   ? 
_citation.pdbx_database_id_DOI      ? 
# 
loop_
_citation_author.citation_id 
_citation_author.name 
_citation_author.identifier_ORCID 
_citation_author.ordinal 
primary 'Aschenbrenner, J.C.' ? 1  
primary 'Saini, M.'           ? 2  
primary 'Chopra, A.'          ? 3  
primary 'Marples, P.G.'       ? 4  
primary 'Balcomb, B.H.'       ? 5  
primary 'Lithgo, R.M.'        ? 6  
primary 'Fearon, D.'          ? 7  
primary 'von Delft, F.'       ? 8  
primary 'Ruiz, F.X.'          ? 9  
primary 'Arnold, E.'          ? 10 
# 
loop_
_entity.id 
_entity.type 
_entity.src_method 
_entity.pdbx_description 
_entity.formula_weight 
_entity.pdbx_number_of_molecules 
_entity.pdbx_ec 
_entity.pdbx_mutation 
_entity.pdbx_fragment 
_entity.details 
1 polymer     man 'NS5 RNA-dependent RNA polymerase'                               73890.008 1   ? ? ? ? 
2 non-polymer syn 'ZINC ION'                                                       65.409    2   ? ? ? ? 
3 non-polymer syn '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                           195.237   1   ? ? ? ? 
4 non-polymer syn 'DIMETHYL SULFOXIDE'                                             78.133    3   ? ? ? ? 
5 non-polymer syn 'DI(HYDROXYETHYL)ETHER'                                          106.120   2   ? ? ? ? 
6 non-polymer syn 'PHOSPHATE ION'                                                  94.971    2   ? ? ? ? 
7 non-polymer syn '2-[(3-fluorophenyl)methyl]-1lambda~6~,2-thiazolidine-1,1-dione' 229.271   1   ? ? ? ? 
8 water       nat water                                                            18.015    414 ? ? ? ? 
# 
_entity_poly.entity_id                      1 
_entity_poly.type                           'polypeptide(L)' 
_entity_poly.nstd_linkage                   no 
_entity_poly.nstd_monomer                   no 
_entity_poly.pdbx_seq_one_letter_code       
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_seq_one_letter_code_can   
;GPGIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAM
TDTTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAR
EAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENS
LSGVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRP
TPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGD
DCVVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQG
AGWSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPW
MEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_entity_poly.pdbx_strand_id                 A 
_entity_poly.pdbx_target_identifier         ? 
# 
loop_
_pdbx_entity_nonpoly.entity_id 
_pdbx_entity_nonpoly.name 
_pdbx_entity_nonpoly.comp_id 
2 'ZINC ION'                                                       ZN  
3 '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                           MES 
4 'DIMETHYL SULFOXIDE'                                             DMS 
5 'DI(HYDROXYETHYL)ETHER'                                          PEG 
6 'PHOSPHATE ION'                                                  PO4 
7 '2-[(3-fluorophenyl)methyl]-1lambda~6~,2-thiazolidine-1,1-dione' WHM 
8 water                                                            HOH 
# 
loop_
_entity_poly_seq.entity_id 
_entity_poly_seq.num 
_entity_poly_seq.mon_id 
_entity_poly_seq.hetero 
1 1   GLY n 
1 2   PRO n 
1 3   GLY n 
1 4   ILE n 
1 5   GLU n 
1 6   SER n 
1 7   GLU n 
1 8   THR n 
1 9   PRO n 
1 10  ASN n 
1 11  LEU n 
1 12  ASP n 
1 13  ILE n 
1 14  ILE n 
1 15  GLY n 
1 16  LYS n 
1 17  ARG n 
1 18  ILE n 
1 19  GLU n 
1 20  LYS n 
1 21  ILE n 
1 22  LYS n 
1 23  GLN n 
1 24  GLU n 
1 25  HIS n 
1 26  GLU n 
1 27  THR n 
1 28  SER n 
1 29  TRP n 
1 30  HIS n 
1 31  TYR n 
1 32  ASP n 
1 33  GLN n 
1 34  ASP n 
1 35  HIS n 
1 36  PRO n 
1 37  TYR n 
1 38  LYS n 
1 39  THR n 
1 40  TRP n 
1 41  ALA n 
1 42  TYR n 
1 43  HIS n 
1 44  GLY n 
1 45  SER n 
1 46  TYR n 
1 47  GLU n 
1 48  THR n 
1 49  LYS n 
1 50  GLN n 
1 51  THR n 
1 52  GLY n 
1 53  SER n 
1 54  ALA n 
1 55  SER n 
1 56  SER n 
1 57  MET n 
1 58  VAL n 
1 59  ASN n 
1 60  GLY n 
1 61  VAL n 
1 62  VAL n 
1 63  ARG n 
1 64  LEU n 
1 65  LEU n 
1 66  THR n 
1 67  LYS n 
1 68  PRO n 
1 69  TRP n 
1 70  ASP n 
1 71  ILE n 
1 72  ILE n 
1 73  PRO n 
1 74  MET n 
1 75  VAL n 
1 76  THR n 
1 77  GLN n 
1 78  MET n 
1 79  ALA n 
1 80  MET n 
1 81  THR n 
1 82  ASP n 
1 83  THR n 
1 84  THR n 
1 85  PRO n 
1 86  PHE n 
1 87  GLY n 
1 88  GLN n 
1 89  GLN n 
1 90  ARG n 
1 91  VAL n 
1 92  PHE n 
1 93  LYS n 
1 94  GLU n 
1 95  LYS n 
1 96  VAL n 
1 97  ASP n 
1 98  THR n 
1 99  ARG n 
1 100 THR n 
1 101 GLN n 
1 102 GLU n 
1 103 PRO n 
1 104 LYS n 
1 105 GLU n 
1 106 GLY n 
1 107 THR n 
1 108 LYS n 
1 109 LYS n 
1 110 LEU n 
1 111 MET n 
1 112 LYS n 
1 113 ILE n 
1 114 THR n 
1 115 ALA n 
1 116 GLU n 
1 117 TRP n 
1 118 LEU n 
1 119 TRP n 
1 120 LYS n 
1 121 GLU n 
1 122 LEU n 
1 123 GLY n 
1 124 LYS n 
1 125 LYS n 
1 126 LYS n 
1 127 THR n 
1 128 PRO n 
1 129 ARG n 
1 130 MET n 
1 131 CYS n 
1 132 THR n 
1 133 ARG n 
1 134 GLU n 
1 135 GLU n 
1 136 PHE n 
1 137 THR n 
1 138 ARG n 
1 139 LYS n 
1 140 VAL n 
1 141 ARG n 
1 142 SER n 
1 143 ASN n 
1 144 ALA n 
1 145 ALA n 
1 146 LEU n 
1 147 GLY n 
1 148 ALA n 
1 149 ILE n 
1 150 PHE n 
1 151 THR n 
1 152 ASP n 
1 153 GLU n 
1 154 ASN n 
1 155 LYS n 
1 156 TRP n 
1 157 LYS n 
1 158 SER n 
1 159 ALA n 
1 160 ARG n 
1 161 GLU n 
1 162 ALA n 
1 163 VAL n 
1 164 GLU n 
1 165 ASP n 
1 166 SER n 
1 167 GLY n 
1 168 PHE n 
1 169 TRP n 
1 170 GLU n 
1 171 LEU n 
1 172 VAL n 
1 173 ASP n 
1 174 LYS n 
1 175 GLU n 
1 176 ARG n 
1 177 ASN n 
1 178 LEU n 
1 179 HIS n 
1 180 LEU n 
1 181 GLU n 
1 182 GLY n 
1 183 LYS n 
1 184 CYS n 
1 185 GLU n 
1 186 THR n 
1 187 CYS n 
1 188 VAL n 
1 189 TYR n 
1 190 ASN n 
1 191 MET n 
1 192 MET n 
1 193 GLY n 
1 194 LYS n 
1 195 ARG n 
1 196 GLU n 
1 197 LYS n 
1 198 LYS n 
1 199 LEU n 
1 200 GLY n 
1 201 GLU n 
1 202 PHE n 
1 203 GLY n 
1 204 LYS n 
1 205 ALA n 
1 206 LYS n 
1 207 GLY n 
1 208 SER n 
1 209 ARG n 
1 210 ALA n 
1 211 ILE n 
1 212 TRP n 
1 213 TYR n 
1 214 MET n 
1 215 TRP n 
1 216 LEU n 
1 217 GLY n 
1 218 ALA n 
1 219 ARG n 
1 220 PHE n 
1 221 LEU n 
1 222 GLU n 
1 223 PHE n 
1 224 GLU n 
1 225 ALA n 
1 226 LEU n 
1 227 GLY n 
1 228 PHE n 
1 229 LEU n 
1 230 ASN n 
1 231 GLU n 
1 232 ASP n 
1 233 HIS n 
1 234 TRP n 
1 235 PHE n 
1 236 SER n 
1 237 ARG n 
1 238 GLU n 
1 239 ASN n 
1 240 SER n 
1 241 LEU n 
1 242 SER n 
1 243 GLY n 
1 244 VAL n 
1 245 GLU n 
1 246 GLY n 
1 247 GLU n 
1 248 GLY n 
1 249 LEU n 
1 250 HIS n 
1 251 LYS n 
1 252 LEU n 
1 253 GLY n 
1 254 TYR n 
1 255 ILE n 
1 256 LEU n 
1 257 ARG n 
1 258 ASP n 
1 259 VAL n 
1 260 SER n 
1 261 LYS n 
1 262 LYS n 
1 263 GLU n 
1 264 GLY n 
1 265 GLY n 
1 266 ALA n 
1 267 MET n 
1 268 TYR n 
1 269 ALA n 
1 270 ASP n 
1 271 ASP n 
1 272 THR n 
1 273 ALA n 
1 274 GLY n 
1 275 TRP n 
1 276 ASP n 
1 277 THR n 
1 278 ARG n 
1 279 ILE n 
1 280 THR n 
1 281 LEU n 
1 282 GLU n 
1 283 ASP n 
1 284 LEU n 
1 285 LYS n 
1 286 ASN n 
1 287 GLU n 
1 288 GLU n 
1 289 MET n 
1 290 VAL n 
1 291 THR n 
1 292 ASN n 
1 293 HIS n 
1 294 MET n 
1 295 GLU n 
1 296 GLY n 
1 297 GLU n 
1 298 HIS n 
1 299 LYS n 
1 300 LYS n 
1 301 LEU n 
1 302 ALA n 
1 303 GLU n 
1 304 ALA n 
1 305 ILE n 
1 306 PHE n 
1 307 LYS n 
1 308 LEU n 
1 309 THR n 
1 310 TYR n 
1 311 GLN n 
1 312 ASN n 
1 313 LYS n 
1 314 VAL n 
1 315 VAL n 
1 316 ARG n 
1 317 VAL n 
1 318 GLN n 
1 319 ARG n 
1 320 PRO n 
1 321 THR n 
1 322 PRO n 
1 323 ARG n 
1 324 GLY n 
1 325 THR n 
1 326 VAL n 
1 327 MET n 
1 328 ASP n 
1 329 ILE n 
1 330 ILE n 
1 331 SER n 
1 332 ARG n 
1 333 ARG n 
1 334 ASP n 
1 335 GLN n 
1 336 ARG n 
1 337 GLY n 
1 338 SER n 
1 339 GLY n 
1 340 GLN n 
1 341 VAL n 
1 342 VAL n 
1 343 THR n 
1 344 TYR n 
1 345 GLY n 
1 346 LEU n 
1 347 ASN n 
1 348 THR n 
1 349 PHE n 
1 350 THR n 
1 351 ASN n 
1 352 MET n 
1 353 GLU n 
1 354 ALA n 
1 355 GLN n 
1 356 LEU n 
1 357 ILE n 
1 358 ARG n 
1 359 GLN n 
1 360 MET n 
1 361 GLU n 
1 362 GLY n 
1 363 GLU n 
1 364 GLY n 
1 365 VAL n 
1 366 PHE n 
1 367 LYS n 
1 368 SER n 
1 369 ILE n 
1 370 GLN n 
1 371 HIS n 
1 372 LEU n 
1 373 THR n 
1 374 VAL n 
1 375 THR n 
1 376 GLU n 
1 377 GLU n 
1 378 ILE n 
1 379 ALA n 
1 380 VAL n 
1 381 LYS n 
1 382 ASN n 
1 383 TRP n 
1 384 LEU n 
1 385 VAL n 
1 386 ARG n 
1 387 VAL n 
1 388 GLY n 
1 389 ARG n 
1 390 GLU n 
1 391 ARG n 
1 392 LEU n 
1 393 SER n 
1 394 ARG n 
1 395 MET n 
1 396 ALA n 
1 397 ILE n 
1 398 SER n 
1 399 GLY n 
1 400 ASP n 
1 401 ASP n 
1 402 CYS n 
1 403 VAL n 
1 404 VAL n 
1 405 LYS n 
1 406 PRO n 
1 407 LEU n 
1 408 ASP n 
1 409 ASP n 
1 410 ARG n 
1 411 PHE n 
1 412 ALA n 
1 413 SER n 
1 414 ALA n 
1 415 LEU n 
1 416 THR n 
1 417 ALA n 
1 418 LEU n 
1 419 ASN n 
1 420 ASP n 
1 421 MET n 
1 422 GLY n 
1 423 LYS n 
1 424 VAL n 
1 425 ARG n 
1 426 LYS n 
1 427 ASP n 
1 428 ILE n 
1 429 GLN n 
1 430 GLN n 
1 431 TRP n 
1 432 GLU n 
1 433 PRO n 
1 434 SER n 
1 435 ARG n 
1 436 GLY n 
1 437 TRP n 
1 438 ASN n 
1 439 ASP n 
1 440 TRP n 
1 441 THR n 
1 442 GLN n 
1 443 VAL n 
1 444 PRO n 
1 445 PHE n 
1 446 CYS n 
1 447 SER n 
1 448 HIS n 
1 449 HIS n 
1 450 PHE n 
1 451 HIS n 
1 452 GLU n 
1 453 LEU n 
1 454 ILE n 
1 455 MET n 
1 456 LYS n 
1 457 ASP n 
1 458 GLY n 
1 459 ARG n 
1 460 VAL n 
1 461 LEU n 
1 462 VAL n 
1 463 VAL n 
1 464 PRO n 
1 465 CYS n 
1 466 ARG n 
1 467 ASN n 
1 468 GLN n 
1 469 ASP n 
1 470 GLU n 
1 471 LEU n 
1 472 ILE n 
1 473 GLY n 
1 474 ARG n 
1 475 ALA n 
1 476 ARG n 
1 477 ILE n 
1 478 SER n 
1 479 GLN n 
1 480 GLY n 
1 481 ALA n 
1 482 GLY n 
1 483 TRP n 
1 484 SER n 
1 485 LEU n 
1 486 ARG n 
1 487 GLU n 
1 488 THR n 
1 489 ALA n 
1 490 CYS n 
1 491 LEU n 
1 492 GLY n 
1 493 LYS n 
1 494 SER n 
1 495 TYR n 
1 496 ALA n 
1 497 GLN n 
1 498 MET n 
1 499 TRP n 
1 500 SER n 
1 501 LEU n 
1 502 MET n 
1 503 TYR n 
1 504 PHE n 
1 505 HIS n 
1 506 ARG n 
1 507 ARG n 
1 508 ASP n 
1 509 LEU n 
1 510 ARG n 
1 511 LEU n 
1 512 ALA n 
1 513 ALA n 
1 514 ASN n 
1 515 ALA n 
1 516 ILE n 
1 517 CYS n 
1 518 SER n 
1 519 ALA n 
1 520 VAL n 
1 521 PRO n 
1 522 SER n 
1 523 HIS n 
1 524 TRP n 
1 525 VAL n 
1 526 PRO n 
1 527 THR n 
1 528 SER n 
1 529 ARG n 
1 530 THR n 
1 531 THR n 
1 532 TRP n 
1 533 SER n 
1 534 ILE n 
1 535 HIS n 
1 536 ALA n 
1 537 THR n 
1 538 HIS n 
1 539 GLU n 
1 540 TRP n 
1 541 MET n 
1 542 THR n 
1 543 THR n 
1 544 GLU n 
1 545 ASP n 
1 546 MET n 
1 547 LEU n 
1 548 THR n 
1 549 VAL n 
1 550 TRP n 
1 551 ASN n 
1 552 ARG n 
1 553 VAL n 
1 554 TRP n 
1 555 ILE n 
1 556 GLN n 
1 557 GLU n 
1 558 ASN n 
1 559 PRO n 
1 560 TRP n 
1 561 MET n 
1 562 GLU n 
1 563 ASP n 
1 564 LYS n 
1 565 THR n 
1 566 PRO n 
1 567 VAL n 
1 568 GLU n 
1 569 SER n 
1 570 TRP n 
1 571 GLU n 
1 572 GLU n 
1 573 ILE n 
1 574 PRO n 
1 575 TYR n 
1 576 LEU n 
1 577 GLY n 
1 578 LYS n 
1 579 ARG n 
1 580 GLU n 
1 581 ASP n 
1 582 GLN n 
1 583 TRP n 
1 584 CYS n 
1 585 GLY n 
1 586 SER n 
1 587 LEU n 
1 588 ILE n 
1 589 GLY n 
1 590 LEU n 
1 591 THR n 
1 592 SER n 
1 593 ARG n 
1 594 ALA n 
1 595 THR n 
1 596 TRP n 
1 597 ALA n 
1 598 LYS n 
1 599 ASN n 
1 600 ILE n 
1 601 GLN n 
1 602 THR n 
1 603 ALA n 
1 604 ILE n 
1 605 ASN n 
1 606 GLN n 
1 607 VAL n 
1 608 ARG n 
1 609 SER n 
1 610 LEU n 
1 611 ILE n 
1 612 GLY n 
1 613 ASN n 
1 614 GLU n 
1 615 GLU n 
1 616 TYR n 
1 617 THR n 
1 618 ASP n 
1 619 TYR n 
1 620 MET n 
1 621 PRO n 
1 622 SER n 
1 623 MET n 
1 624 LYS n 
1 625 ARG n 
1 626 PHE n 
1 627 ARG n 
1 628 ARG n 
1 629 GLU n 
1 630 GLU n 
1 631 GLU n 
1 632 GLU n 
1 633 ALA n 
1 634 GLY n 
1 635 VAL n 
1 636 LEU n 
1 637 TRP n 
# 
_entity_src_gen.entity_id                          1 
_entity_src_gen.pdbx_src_id                        1 
_entity_src_gen.pdbx_alt_source_flag               sample 
_entity_src_gen.pdbx_seq_type                      'Biological sequence' 
_entity_src_gen.pdbx_beg_seq_num                   1 
_entity_src_gen.pdbx_end_seq_num                   637 
_entity_src_gen.gene_src_common_name               ? 
_entity_src_gen.gene_src_genus                     ? 
_entity_src_gen.pdbx_gene_src_gene                 ? 
_entity_src_gen.gene_src_species                   ? 
_entity_src_gen.gene_src_strain                    ? 
_entity_src_gen.gene_src_tissue                    ? 
_entity_src_gen.gene_src_tissue_fraction           ? 
_entity_src_gen.gene_src_details                   ? 
_entity_src_gen.pdbx_gene_src_fragment             ? 
_entity_src_gen.pdbx_gene_src_scientific_name      'dengue virus type 2' 
_entity_src_gen.pdbx_gene_src_ncbi_taxonomy_id     11060 
_entity_src_gen.pdbx_gene_src_variant              ? 
_entity_src_gen.pdbx_gene_src_cell_line            ? 
_entity_src_gen.pdbx_gene_src_atcc                 ? 
_entity_src_gen.pdbx_gene_src_organ                ? 
_entity_src_gen.pdbx_gene_src_organelle            ? 
_entity_src_gen.pdbx_gene_src_cell                 ? 
_entity_src_gen.pdbx_gene_src_cellular_location    ? 
_entity_src_gen.host_org_common_name               ? 
_entity_src_gen.pdbx_host_org_scientific_name      'Escherichia coli' 
_entity_src_gen.pdbx_host_org_ncbi_taxonomy_id     562 
_entity_src_gen.host_org_genus                     ? 
_entity_src_gen.pdbx_host_org_gene                 ? 
_entity_src_gen.pdbx_host_org_organ                ? 
_entity_src_gen.host_org_species                   ? 
_entity_src_gen.pdbx_host_org_tissue               ? 
_entity_src_gen.pdbx_host_org_tissue_fraction      ? 
_entity_src_gen.pdbx_host_org_strain               ? 
_entity_src_gen.pdbx_host_org_variant              ? 
_entity_src_gen.pdbx_host_org_cell_line            ? 
_entity_src_gen.pdbx_host_org_atcc                 ? 
_entity_src_gen.pdbx_host_org_culture_collection   ? 
_entity_src_gen.pdbx_host_org_cell                 ? 
_entity_src_gen.pdbx_host_org_organelle            ? 
_entity_src_gen.pdbx_host_org_cellular_location    ? 
_entity_src_gen.pdbx_host_org_vector_type          ? 
_entity_src_gen.pdbx_host_org_vector               ? 
_entity_src_gen.host_org_details                   ? 
_entity_src_gen.expression_system_id               ? 
_entity_src_gen.plasmid_name                       ? 
_entity_src_gen.plasmid_details                    ? 
_entity_src_gen.pdbx_description                   ? 
# 
loop_
_chem_comp.id 
_chem_comp.type 
_chem_comp.mon_nstd_flag 
_chem_comp.name 
_chem_comp.pdbx_synonyms 
_chem_comp.formula 
_chem_comp.formula_weight 
ALA 'L-peptide linking' y ALANINE                                                          ? 'C3 H7 N O2'       89.093  
ARG 'L-peptide linking' y ARGININE                                                         ? 'C6 H15 N4 O2 1'   175.209 
ASN 'L-peptide linking' y ASPARAGINE                                                       ? 'C4 H8 N2 O3'      132.118 
ASP 'L-peptide linking' y 'ASPARTIC ACID'                                                  ? 'C4 H7 N O4'       133.103 
CYS 'L-peptide linking' y CYSTEINE                                                         ? 'C3 H7 N O2 S'     121.158 
DMS non-polymer         . 'DIMETHYL SULFOXIDE'                                             ? 'C2 H6 O S'        78.133  
GLN 'L-peptide linking' y GLUTAMINE                                                        ? 'C5 H10 N2 O3'     146.144 
GLU 'L-peptide linking' y 'GLUTAMIC ACID'                                                  ? 'C5 H9 N O4'       147.129 
GLY 'peptide linking'   y GLYCINE                                                          ? 'C2 H5 N O2'       75.067  
HIS 'L-peptide linking' y HISTIDINE                                                        ? 'C6 H10 N3 O2 1'   156.162 
HOH non-polymer         . WATER                                                            ? 'H2 O'             18.015  
ILE 'L-peptide linking' y ISOLEUCINE                                                       ? 'C6 H13 N O2'      131.173 
LEU 'L-peptide linking' y LEUCINE                                                          ? 'C6 H13 N O2'      131.173 
LYS 'L-peptide linking' y LYSINE                                                           ? 'C6 H15 N2 O2 1'   147.195 
MES non-polymer         . '2-(N-MORPHOLINO)-ETHANESULFONIC ACID'                           ? 'C6 H13 N O4 S'    195.237 
MET 'L-peptide linking' y METHIONINE                                                       ? 'C5 H11 N O2 S'    149.211 
PEG non-polymer         . 'DI(HYDROXYETHYL)ETHER'                                          ? 'C4 H10 O3'        106.120 
PHE 'L-peptide linking' y PHENYLALANINE                                                    ? 'C9 H11 N O2'      165.189 
PO4 non-polymer         . 'PHOSPHATE ION'                                                  ? 'O4 P -3'          94.971  
PRO 'L-peptide linking' y PROLINE                                                          ? 'C5 H9 N O2'       115.130 
SER 'L-peptide linking' y SERINE                                                           ? 'C3 H7 N O3'       105.093 
THR 'L-peptide linking' y THREONINE                                                        ? 'C4 H9 N O3'       119.119 
TRP 'L-peptide linking' y TRYPTOPHAN                                                       ? 'C11 H12 N2 O2'    204.225 
TYR 'L-peptide linking' y TYROSINE                                                         ? 'C9 H11 N O3'      181.189 
VAL 'L-peptide linking' y VALINE                                                           ? 'C5 H11 N O2'      117.146 
WHM non-polymer         . '2-[(3-fluorophenyl)methyl]-1lambda~6~,2-thiazolidine-1,1-dione' ? 'C10 H12 F N O2 S' 229.271 
ZN  non-polymer         . 'ZINC ION'                                                       ? 'Zn 2'             65.409  
# 
loop_
_pdbx_poly_seq_scheme.asym_id 
_pdbx_poly_seq_scheme.entity_id 
_pdbx_poly_seq_scheme.seq_id 
_pdbx_poly_seq_scheme.mon_id 
_pdbx_poly_seq_scheme.ndb_seq_num 
_pdbx_poly_seq_scheme.pdb_seq_num 
_pdbx_poly_seq_scheme.auth_seq_num 
_pdbx_poly_seq_scheme.pdb_mon_id 
_pdbx_poly_seq_scheme.auth_mon_id 
_pdbx_poly_seq_scheme.pdb_strand_id 
_pdbx_poly_seq_scheme.pdb_ins_code 
_pdbx_poly_seq_scheme.hetero 
A 1 1   GLY 1   264 ?   ?   ?   A . n 
A 1 2   PRO 2   265 ?   ?   ?   A . n 
A 1 3   GLY 3   266 ?   ?   ?   A . n 
A 1 4   ILE 4   267 ?   ?   ?   A . n 
A 1 5   GLU 5   268 ?   ?   ?   A . n 
A 1 6   SER 6   269 ?   ?   ?   A . n 
A 1 7   GLU 7   270 ?   ?   ?   A . n 
A 1 8   THR 8   271 ?   ?   ?   A . n 
A 1 9   PRO 9   272 ?   ?   ?   A . n 
A 1 10  ASN 10  273 273 ASN ASN A . n 
A 1 11  LEU 11  274 274 LEU LEU A . n 
A 1 12  ASP 12  275 275 ASP ASP A . n 
A 1 13  ILE 13  276 276 ILE ILE A . n 
A 1 14  ILE 14  277 277 ILE ILE A . n 
A 1 15  GLY 15  278 278 GLY GLY A . n 
A 1 16  LYS 16  279 279 LYS LYS A . n 
A 1 17  ARG 17  280 280 ARG ARG A . n 
A 1 18  ILE 18  281 281 ILE ILE A . n 
A 1 19  GLU 19  282 282 GLU GLU A . n 
A 1 20  LYS 20  283 283 LYS LYS A . n 
A 1 21  ILE 21  284 284 ILE ILE A . n 
A 1 22  LYS 22  285 285 LYS LYS A . n 
A 1 23  GLN 23  286 286 GLN GLN A . n 
A 1 24  GLU 24  287 287 GLU GLU A . n 
A 1 25  HIS 25  288 288 HIS HIS A . n 
A 1 26  GLU 26  289 289 GLU GLU A . n 
A 1 27  THR 27  290 290 THR THR A . n 
A 1 28  SER 28  291 291 SER SER A . n 
A 1 29  TRP 29  292 292 TRP TRP A . n 
A 1 30  HIS 30  293 293 HIS HIS A . n 
A 1 31  TYR 31  294 294 TYR TYR A . n 
A 1 32  ASP 32  295 295 ASP ASP A . n 
A 1 33  GLN 33  296 296 GLN GLN A . n 
A 1 34  ASP 34  297 297 ASP ASP A . n 
A 1 35  HIS 35  298 298 HIS HIS A . n 
A 1 36  PRO 36  299 299 PRO PRO A . n 
A 1 37  TYR 37  300 300 TYR TYR A . n 
A 1 38  LYS 38  301 301 LYS LYS A . n 
A 1 39  THR 39  302 302 THR THR A . n 
A 1 40  TRP 40  303 303 TRP TRP A . n 
A 1 41  ALA 41  304 304 ALA ALA A . n 
A 1 42  TYR 42  305 305 TYR TYR A . n 
A 1 43  HIS 43  306 306 HIS HIS A . n 
A 1 44  GLY 44  307 307 GLY GLY A . n 
A 1 45  SER 45  308 308 SER SER A . n 
A 1 46  TYR 46  309 309 TYR TYR A . n 
A 1 47  GLU 47  310 310 GLU GLU A . n 
A 1 48  THR 48  311 311 THR THR A . n 
A 1 49  LYS 49  312 312 LYS LYS A . n 
A 1 50  GLN 50  313 ?   ?   ?   A . n 
A 1 51  THR 51  314 ?   ?   ?   A . n 
A 1 52  GLY 52  315 ?   ?   ?   A . n 
A 1 53  SER 53  316 ?   ?   ?   A . n 
A 1 54  ALA 54  317 317 ALA ALA A . n 
A 1 55  SER 55  318 318 SER SER A . n 
A 1 56  SER 56  319 319 SER SER A . n 
A 1 57  MET 57  320 320 MET MET A . n 
A 1 58  VAL 58  321 321 VAL VAL A . n 
A 1 59  ASN 59  322 322 ASN ASN A . n 
A 1 60  GLY 60  323 323 GLY GLY A . n 
A 1 61  VAL 61  324 324 VAL VAL A . n 
A 1 62  VAL 62  325 325 VAL VAL A . n 
A 1 63  ARG 63  326 326 ARG ARG A . n 
A 1 64  LEU 64  327 327 LEU LEU A . n 
A 1 65  LEU 65  328 328 LEU LEU A . n 
A 1 66  THR 66  329 329 THR THR A . n 
A 1 67  LYS 67  330 330 LYS LYS A . n 
A 1 68  PRO 68  331 331 PRO PRO A . n 
A 1 69  TRP 69  332 332 TRP TRP A . n 
A 1 70  ASP 70  333 333 ASP ASP A . n 
A 1 71  ILE 71  334 334 ILE ILE A . n 
A 1 72  ILE 72  335 335 ILE ILE A . n 
A 1 73  PRO 73  336 336 PRO PRO A . n 
A 1 74  MET 74  337 337 MET MET A . n 
A 1 75  VAL 75  338 338 VAL VAL A . n 
A 1 76  THR 76  339 339 THR THR A . n 
A 1 77  GLN 77  340 340 GLN GLN A . n 
A 1 78  MET 78  341 341 MET MET A . n 
A 1 79  ALA 79  342 342 ALA ALA A . n 
A 1 80  MET 80  343 343 MET MET A . n 
A 1 81  THR 81  344 344 THR GLY A . n 
A 1 82  ASP 82  345 ?   ?   ?   A . n 
A 1 83  THR 83  346 ?   ?   ?   A . n 
A 1 84  THR 84  347 ?   ?   ?   A . n 
A 1 85  PRO 85  348 ?   ?   ?   A . n 
A 1 86  PHE 86  349 ?   ?   ?   A . n 
A 1 87  GLY 87  350 ?   ?   ?   A . n 
A 1 88  GLN 88  351 ?   ?   ?   A . n 
A 1 89  GLN 89  352 ?   ?   ?   A . n 
A 1 90  ARG 90  353 ?   ?   ?   A . n 
A 1 91  VAL 91  354 ?   ?   ?   A . n 
A 1 92  PHE 92  355 ?   ?   ?   A . n 
A 1 93  LYS 93  356 356 LYS LYS A . n 
A 1 94  GLU 94  357 357 GLU GLU A . n 
A 1 95  LYS 95  358 358 LYS LYS A . n 
A 1 96  VAL 96  359 359 VAL VAL A . n 
A 1 97  ASP 97  360 360 ASP ASP A . n 
A 1 98  THR 98  361 361 THR THR A . n 
A 1 99  ARG 99  362 362 ARG ARG A . n 
A 1 100 THR 100 363 363 THR THR A . n 
A 1 101 GLN 101 364 364 GLN GLN A . n 
A 1 102 GLU 102 365 365 GLU GLU A . n 
A 1 103 PRO 103 366 366 PRO PRO A . n 
A 1 104 LYS 104 367 367 LYS LYS A . n 
A 1 105 GLU 105 368 368 GLU GLU A . n 
A 1 106 GLY 106 369 369 GLY GLY A . n 
A 1 107 THR 107 370 370 THR THR A . n 
A 1 108 LYS 108 371 371 LYS LYS A . n 
A 1 109 LYS 109 372 372 LYS LYS A . n 
A 1 110 LEU 110 373 373 LEU LEU A . n 
A 1 111 MET 111 374 374 MET MET A . n 
A 1 112 LYS 112 375 375 LYS LYS A . n 
A 1 113 ILE 113 376 376 ILE ILE A . n 
A 1 114 THR 114 377 377 THR THR A . n 
A 1 115 ALA 115 378 378 ALA ALA A . n 
A 1 116 GLU 116 379 379 GLU GLU A . n 
A 1 117 TRP 117 380 380 TRP TRP A . n 
A 1 118 LEU 118 381 381 LEU LEU A . n 
A 1 119 TRP 119 382 382 TRP TRP A . n 
A 1 120 LYS 120 383 383 LYS LYS A . n 
A 1 121 GLU 121 384 384 GLU GLU A . n 
A 1 122 LEU 122 385 385 LEU LEU A . n 
A 1 123 GLY 123 386 386 GLY GLY A . n 
A 1 124 LYS 124 387 387 LYS LYS A . n 
A 1 125 LYS 125 388 388 LYS LYS A . n 
A 1 126 LYS 126 389 389 LYS LYS A . n 
A 1 127 THR 127 390 390 THR THR A . n 
A 1 128 PRO 128 391 391 PRO PRO A . n 
A 1 129 ARG 129 392 392 ARG ARG A . n 
A 1 130 MET 130 393 393 MET MET A . n 
A 1 131 CYS 131 394 394 CYS CYS A . n 
A 1 132 THR 132 395 395 THR THR A . n 
A 1 133 ARG 133 396 396 ARG ARG A . n 
A 1 134 GLU 134 397 397 GLU GLU A . n 
A 1 135 GLU 135 398 398 GLU GLU A . n 
A 1 136 PHE 136 399 399 PHE PHE A . n 
A 1 137 THR 137 400 400 THR THR A . n 
A 1 138 ARG 138 401 401 ARG ARG A . n 
A 1 139 LYS 139 402 402 LYS LYS A . n 
A 1 140 VAL 140 403 403 VAL VAL A . n 
A 1 141 ARG 141 404 404 ARG ARG A . n 
A 1 142 SER 142 405 405 SER SER A . n 
A 1 143 ASN 143 406 406 ASN ASN A . n 
A 1 144 ALA 144 407 407 ALA ALA A . n 
A 1 145 ALA 145 408 408 ALA ALA A . n 
A 1 146 LEU 146 409 409 LEU LEU A . n 
A 1 147 GLY 147 410 410 GLY GLY A . n 
A 1 148 ALA 148 411 411 ALA ALA A . n 
A 1 149 ILE 149 412 412 ILE ILE A . n 
A 1 150 PHE 150 413 ?   ?   ?   A . n 
A 1 151 THR 151 414 ?   ?   ?   A . n 
A 1 152 ASP 152 415 ?   ?   ?   A . n 
A 1 153 GLU 153 416 ?   ?   ?   A . n 
A 1 154 ASN 154 417 ?   ?   ?   A . n 
A 1 155 LYS 155 418 ?   ?   ?   A . n 
A 1 156 TRP 156 419 419 TRP TRP A . n 
A 1 157 LYS 157 420 420 LYS LYS A . n 
A 1 158 SER 158 421 421 SER SER A . n 
A 1 159 ALA 159 422 422 ALA ALA A . n 
A 1 160 ARG 160 423 423 ARG ARG A . n 
A 1 161 GLU 161 424 424 GLU GLU A . n 
A 1 162 ALA 162 425 425 ALA ALA A . n 
A 1 163 VAL 163 426 426 VAL VAL A . n 
A 1 164 GLU 164 427 427 GLU GLU A . n 
A 1 165 ASP 165 428 428 ASP ASP A . n 
A 1 166 SER 166 429 429 SER SER A . n 
A 1 167 GLY 167 430 430 GLY GLY A . n 
A 1 168 PHE 168 431 431 PHE PHE A . n 
A 1 169 TRP 169 432 432 TRP TRP A . n 
A 1 170 GLU 170 433 433 GLU GLU A . n 
A 1 171 LEU 171 434 434 LEU LEU A . n 
A 1 172 VAL 172 435 435 VAL VAL A . n 
A 1 173 ASP 173 436 436 ASP ASP A . n 
A 1 174 LYS 174 437 437 LYS LYS A . n 
A 1 175 GLU 175 438 438 GLU GLU A . n 
A 1 176 ARG 176 439 439 ARG ARG A . n 
A 1 177 ASN 177 440 440 ASN ASN A . n 
A 1 178 LEU 178 441 441 LEU LEU A . n 
A 1 179 HIS 179 442 442 HIS HIS A . n 
A 1 180 LEU 180 443 443 LEU LEU A . n 
A 1 181 GLU 181 444 444 GLU GLU A . n 
A 1 182 GLY 182 445 445 GLY GLY A . n 
A 1 183 LYS 183 446 446 LYS LYS A . n 
A 1 184 CYS 184 447 447 CYS CYS A . n 
A 1 185 GLU 185 448 448 GLU GLU A . n 
A 1 186 THR 186 449 449 THR THR A . n 
A 1 187 CYS 187 450 450 CYS CYS A . n 
A 1 188 VAL 188 451 451 VAL VAL A . n 
A 1 189 TYR 189 452 452 TYR TYR A . n 
A 1 190 ASN 190 453 453 ASN ASN A . n 
A 1 191 MET 191 454 454 MET MET A . n 
A 1 192 MET 192 455 455 MET MET A . n 
A 1 193 GLY 193 456 ?   ?   ?   A . n 
A 1 194 LYS 194 457 ?   ?   ?   A . n 
A 1 195 ARG 195 458 ?   ?   ?   A . n 
A 1 196 GLU 196 459 ?   ?   ?   A . n 
A 1 197 LYS 197 460 ?   ?   ?   A . n 
A 1 198 LYS 198 461 ?   ?   ?   A . n 
A 1 199 LEU 199 462 ?   ?   ?   A . n 
A 1 200 GLY 200 463 ?   ?   ?   A . n 
A 1 201 GLU 201 464 ?   ?   ?   A . n 
A 1 202 PHE 202 465 ?   ?   ?   A . n 
A 1 203 GLY 203 466 ?   ?   ?   A . n 
A 1 204 LYS 204 467 ?   ?   ?   A . n 
A 1 205 ALA 205 468 ?   ?   ?   A . n 
A 1 206 LYS 206 469 ?   ?   ?   A . n 
A 1 207 GLY 207 470 ?   ?   ?   A . n 
A 1 208 SER 208 471 ?   ?   ?   A . n 
A 1 209 ARG 209 472 ?   ?   ?   A . n 
A 1 210 ALA 210 473 473 ALA ALA A . n 
A 1 211 ILE 211 474 474 ILE ILE A . n 
A 1 212 TRP 212 475 475 TRP TRP A . n 
A 1 213 TYR 213 476 476 TYR TYR A . n 
A 1 214 MET 214 477 477 MET MET A . n 
A 1 215 TRP 215 478 478 TRP TRP A . n 
A 1 216 LEU 216 479 479 LEU LEU A . n 
A 1 217 GLY 217 480 480 GLY GLY A . n 
A 1 218 ALA 218 481 481 ALA ALA A . n 
A 1 219 ARG 219 482 482 ARG ARG A . n 
A 1 220 PHE 220 483 483 PHE PHE A . n 
A 1 221 LEU 221 484 484 LEU LEU A . n 
A 1 222 GLU 222 485 485 GLU GLU A . n 
A 1 223 PHE 223 486 486 PHE PHE A . n 
A 1 224 GLU 224 487 487 GLU GLU A . n 
A 1 225 ALA 225 488 488 ALA ALA A . n 
A 1 226 LEU 226 489 489 LEU LEU A . n 
A 1 227 GLY 227 490 490 GLY GLY A . n 
A 1 228 PHE 228 491 491 PHE PHE A . n 
A 1 229 LEU 229 492 492 LEU LEU A . n 
A 1 230 ASN 230 493 493 ASN ASN A . n 
A 1 231 GLU 231 494 494 GLU GLU A . n 
A 1 232 ASP 232 495 495 ASP ASP A . n 
A 1 233 HIS 233 496 496 HIS HIS A . n 
A 1 234 TRP 234 497 497 TRP TRP A . n 
A 1 235 PHE 235 498 498 PHE PHE A . n 
A 1 236 SER 236 499 499 SER SER A . n 
A 1 237 ARG 237 500 500 ARG ARG A . n 
A 1 238 GLU 238 501 501 GLU GLU A . n 
A 1 239 ASN 239 502 502 ASN ASN A . n 
A 1 240 SER 240 503 503 SER SER A . n 
A 1 241 LEU 241 504 504 LEU LEU A . n 
A 1 242 SER 242 505 505 SER SER A . n 
A 1 243 GLY 243 506 506 GLY GLY A . n 
A 1 244 VAL 244 507 507 VAL VAL A . n 
A 1 245 GLU 245 508 508 GLU GLU A . n 
A 1 246 GLY 246 509 509 GLY GLY A . n 
A 1 247 GLU 247 510 510 GLU GLU A . n 
A 1 248 GLY 248 511 511 GLY GLY A . n 
A 1 249 LEU 249 512 512 LEU LEU A . n 
A 1 250 HIS 250 513 513 HIS HIS A . n 
A 1 251 LYS 251 514 514 LYS LYS A . n 
A 1 252 LEU 252 515 515 LEU LEU A . n 
A 1 253 GLY 253 516 516 GLY GLY A . n 
A 1 254 TYR 254 517 517 TYR TYR A . n 
A 1 255 ILE 255 518 518 ILE ILE A . n 
A 1 256 LEU 256 519 519 LEU LEU A . n 
A 1 257 ARG 257 520 520 ARG ARG A . n 
A 1 258 ASP 258 521 521 ASP ASP A . n 
A 1 259 VAL 259 522 522 VAL VAL A . n 
A 1 260 SER 260 523 523 SER SER A . n 
A 1 261 LYS 261 524 524 LYS LYS A . n 
A 1 262 LYS 262 525 525 LYS LYS A . n 
A 1 263 GLU 263 526 526 GLU GLU A . n 
A 1 264 GLY 264 527 527 GLY GLY A . n 
A 1 265 GLY 265 528 528 GLY GLY A . n 
A 1 266 ALA 266 529 529 ALA ALA A . n 
A 1 267 MET 267 530 530 MET MET A . n 
A 1 268 TYR 268 531 531 TYR TYR A . n 
A 1 269 ALA 269 532 532 ALA ALA A . n 
A 1 270 ASP 270 533 533 ASP ASP A . n 
A 1 271 ASP 271 534 534 ASP ASP A . n 
A 1 272 THR 272 535 535 THR THR A . n 
A 1 273 ALA 273 536 536 ALA ALA A . n 
A 1 274 GLY 274 537 537 GLY GLY A . n 
A 1 275 TRP 275 538 538 TRP TRP A . n 
A 1 276 ASP 276 539 539 ASP ASP A . n 
A 1 277 THR 277 540 540 THR THR A . n 
A 1 278 ARG 278 541 541 ARG ARG A . n 
A 1 279 ILE 279 542 542 ILE ILE A . n 
A 1 280 THR 280 543 543 THR THR A . n 
A 1 281 LEU 281 544 544 LEU LEU A . n 
A 1 282 GLU 282 545 545 GLU GLU A . n 
A 1 283 ASP 283 546 546 ASP ASP A . n 
A 1 284 LEU 284 547 547 LEU LEU A . n 
A 1 285 LYS 285 548 548 LYS LYS A . n 
A 1 286 ASN 286 549 549 ASN ASN A . n 
A 1 287 GLU 287 550 550 GLU GLU A . n 
A 1 288 GLU 288 551 551 GLU GLU A . n 
A 1 289 MET 289 552 552 MET MET A . n 
A 1 290 VAL 290 553 553 VAL VAL A . n 
A 1 291 THR 291 554 554 THR THR A . n 
A 1 292 ASN 292 555 555 ASN ASN A . n 
A 1 293 HIS 293 556 556 HIS HIS A . n 
A 1 294 MET 294 557 557 MET MET A . n 
A 1 295 GLU 295 558 558 GLU GLU A . n 
A 1 296 GLY 296 559 559 GLY GLY A . n 
A 1 297 GLU 297 560 560 GLU GLU A . n 
A 1 298 HIS 298 561 561 HIS HIS A . n 
A 1 299 LYS 299 562 562 LYS LYS A . n 
A 1 300 LYS 300 563 563 LYS LYS A . n 
A 1 301 LEU 301 564 564 LEU LEU A . n 
A 1 302 ALA 302 565 565 ALA ALA A . n 
A 1 303 GLU 303 566 566 GLU GLU A . n 
A 1 304 ALA 304 567 567 ALA ALA A . n 
A 1 305 ILE 305 568 568 ILE ILE A . n 
A 1 306 PHE 306 569 569 PHE PHE A . n 
A 1 307 LYS 307 570 570 LYS LYS A . n 
A 1 308 LEU 308 571 571 LEU LEU A . n 
A 1 309 THR 309 572 572 THR THR A . n 
A 1 310 TYR 310 573 573 TYR TYR A . n 
A 1 311 GLN 311 574 574 GLN GLN A . n 
A 1 312 ASN 312 575 575 ASN ASN A . n 
A 1 313 LYS 313 576 576 LYS LYS A . n 
A 1 314 VAL 314 577 577 VAL VAL A . n 
A 1 315 VAL 315 578 578 VAL VAL A . n 
A 1 316 ARG 316 579 579 ARG ARG A . n 
A 1 317 VAL 317 580 580 VAL VAL A . n 
A 1 318 GLN 318 581 581 GLN GLN A . n 
A 1 319 ARG 319 582 582 ARG ARG A . n 
A 1 320 PRO 320 583 583 PRO PRO A . n 
A 1 321 THR 321 584 584 THR THR A . n 
A 1 322 PRO 322 585 ?   ?   ?   A . n 
A 1 323 ARG 323 586 ?   ?   ?   A . n 
A 1 324 GLY 324 587 ?   ?   ?   A . n 
A 1 325 THR 325 588 588 THR THR A . n 
A 1 326 VAL 326 589 589 VAL VAL A . n 
A 1 327 MET 327 590 590 MET MET A . n 
A 1 328 ASP 328 591 591 ASP ASP A . n 
A 1 329 ILE 329 592 592 ILE ILE A . n 
A 1 330 ILE 330 593 593 ILE ILE A . n 
A 1 331 SER 331 594 594 SER SER A . n 
A 1 332 ARG 332 595 595 ARG ARG A . n 
A 1 333 ARG 333 596 596 ARG ARG A . n 
A 1 334 ASP 334 597 597 ASP ASP A . n 
A 1 335 GLN 335 598 598 GLN GLN A . n 
A 1 336 ARG 336 599 599 ARG ARG A . n 
A 1 337 GLY 337 600 600 GLY GLY A . n 
A 1 338 SER 338 601 601 SER SER A . n 
A 1 339 GLY 339 602 602 GLY GLY A . n 
A 1 340 GLN 340 603 603 GLN GLN A . n 
A 1 341 VAL 341 604 604 VAL VAL A . n 
A 1 342 VAL 342 605 605 VAL VAL A . n 
A 1 343 THR 343 606 606 THR THR A . n 
A 1 344 TYR 344 607 607 TYR TYR A . n 
A 1 345 GLY 345 608 608 GLY GLY A . n 
A 1 346 LEU 346 609 609 LEU LEU A . n 
A 1 347 ASN 347 610 610 ASN ASN A . n 
A 1 348 THR 348 611 611 THR THR A . n 
A 1 349 PHE 349 612 612 PHE PHE A . n 
A 1 350 THR 350 613 613 THR THR A . n 
A 1 351 ASN 351 614 614 ASN ASN A . n 
A 1 352 MET 352 615 615 MET MET A . n 
A 1 353 GLU 353 616 616 GLU GLU A . n 
A 1 354 ALA 354 617 617 ALA ALA A . n 
A 1 355 GLN 355 618 618 GLN GLN A . n 
A 1 356 LEU 356 619 619 LEU LEU A . n 
A 1 357 ILE 357 620 620 ILE ILE A . n 
A 1 358 ARG 358 621 621 ARG ARG A . n 
A 1 359 GLN 359 622 622 GLN GLN A . n 
A 1 360 MET 360 623 623 MET MET A . n 
A 1 361 GLU 361 624 624 GLU GLU A . n 
A 1 362 GLY 362 625 625 GLY GLY A . n 
A 1 363 GLU 363 626 626 GLU GLU A . n 
A 1 364 GLY 364 627 627 GLY GLY A . n 
A 1 365 VAL 365 628 628 VAL VAL A . n 
A 1 366 PHE 366 629 629 PHE PHE A . n 
A 1 367 LYS 367 630 630 LYS LYS A . n 
A 1 368 SER 368 631 631 SER SER A . n 
A 1 369 ILE 369 632 632 ILE ILE A . n 
A 1 370 GLN 370 633 633 GLN GLN A . n 
A 1 371 HIS 371 634 634 HIS HIS A . n 
A 1 372 LEU 372 635 635 LEU LEU A . n 
A 1 373 THR 373 636 636 THR THR A . n 
A 1 374 VAL 374 637 637 VAL VAL A . n 
A 1 375 THR 375 638 638 THR THR A . n 
A 1 376 GLU 376 639 639 GLU GLU A . n 
A 1 377 GLU 377 640 640 GLU GLU A . n 
A 1 378 ILE 378 641 641 ILE ILE A . n 
A 1 379 ALA 379 642 642 ALA ALA A . n 
A 1 380 VAL 380 643 643 VAL VAL A . n 
A 1 381 LYS 381 644 644 LYS LYS A . n 
A 1 382 ASN 382 645 645 ASN ASN A . n 
A 1 383 TRP 383 646 646 TRP TRP A . n 
A 1 384 LEU 384 647 647 LEU LEU A . n 
A 1 385 VAL 385 648 648 VAL VAL A . n 
A 1 386 ARG 386 649 649 ARG ARG A . n 
A 1 387 VAL 387 650 650 VAL VAL A . n 
A 1 388 GLY 388 651 651 GLY GLY A . n 
A 1 389 ARG 389 652 652 ARG ARG A . n 
A 1 390 GLU 390 653 653 GLU GLU A . n 
A 1 391 ARG 391 654 654 ARG ARG A . n 
A 1 392 LEU 392 655 655 LEU LEU A . n 
A 1 393 SER 393 656 656 SER SER A . n 
A 1 394 ARG 394 657 657 ARG ARG A . n 
A 1 395 MET 395 658 658 MET MET A . n 
A 1 396 ALA 396 659 659 ALA ALA A . n 
A 1 397 ILE 397 660 660 ILE ILE A . n 
A 1 398 SER 398 661 661 SER SER A . n 
A 1 399 GLY 399 662 662 GLY GLY A . n 
A 1 400 ASP 400 663 663 ASP ASP A . n 
A 1 401 ASP 401 664 664 ASP ASP A . n 
A 1 402 CYS 402 665 665 CYS CYS A . n 
A 1 403 VAL 403 666 666 VAL VAL A . n 
A 1 404 VAL 404 667 667 VAL VAL A . n 
A 1 405 LYS 405 668 668 LYS LYS A . n 
A 1 406 PRO 406 669 669 PRO PRO A . n 
A 1 407 LEU 407 670 670 LEU LEU A . n 
A 1 408 ASP 408 671 671 ASP ASP A . n 
A 1 409 ASP 409 672 672 ASP ASP A . n 
A 1 410 ARG 410 673 673 ARG ARG A . n 
A 1 411 PHE 411 674 674 PHE PHE A . n 
A 1 412 ALA 412 675 675 ALA ALA A . n 
A 1 413 SER 413 676 676 SER SER A . n 
A 1 414 ALA 414 677 677 ALA ALA A . n 
A 1 415 LEU 415 678 678 LEU LEU A . n 
A 1 416 THR 416 679 679 THR THR A . n 
A 1 417 ALA 417 680 680 ALA ALA A . n 
A 1 418 LEU 418 681 681 LEU LEU A . n 
A 1 419 ASN 419 682 682 ASN ASN A . n 
A 1 420 ASP 420 683 683 ASP ASP A . n 
A 1 421 MET 421 684 684 MET MET A . n 
A 1 422 GLY 422 685 685 GLY GLY A . n 
A 1 423 LYS 423 686 686 LYS LYS A . n 
A 1 424 VAL 424 687 687 VAL VAL A . n 
A 1 425 ARG 425 688 688 ARG ARG A . n 
A 1 426 LYS 426 689 689 LYS LYS A . n 
A 1 427 ASP 427 690 690 ASP ASP A . n 
A 1 428 ILE 428 691 691 ILE ILE A . n 
A 1 429 GLN 429 692 692 GLN GLN A . n 
A 1 430 GLN 430 693 693 GLN GLN A . n 
A 1 431 TRP 431 694 694 TRP TRP A . n 
A 1 432 GLU 432 695 695 GLU GLU A . n 
A 1 433 PRO 433 696 696 PRO PRO A . n 
A 1 434 SER 434 697 697 SER SER A . n 
A 1 435 ARG 435 698 698 ARG ARG A . n 
A 1 436 GLY 436 699 699 GLY GLY A . n 
A 1 437 TRP 437 700 700 TRP TRP A . n 
A 1 438 ASN 438 701 701 ASN ASN A . n 
A 1 439 ASP 439 702 702 ASP ASP A . n 
A 1 440 TRP 440 703 703 TRP TRP A . n 
A 1 441 THR 441 704 704 THR THR A . n 
A 1 442 GLN 442 705 705 GLN GLN A . n 
A 1 443 VAL 443 706 706 VAL VAL A . n 
A 1 444 PRO 444 707 707 PRO PRO A . n 
A 1 445 PHE 445 708 708 PHE PHE A . n 
A 1 446 CYS 446 709 709 CYS CYS A . n 
A 1 447 SER 447 710 710 SER SER A . n 
A 1 448 HIS 448 711 711 HIS HIS A . n 
A 1 449 HIS 449 712 712 HIS HIS A . n 
A 1 450 PHE 450 713 713 PHE PHE A . n 
A 1 451 HIS 451 714 714 HIS HIS A . n 
A 1 452 GLU 452 715 715 GLU GLU A . n 
A 1 453 LEU 453 716 716 LEU LEU A . n 
A 1 454 ILE 454 717 717 ILE ILE A . n 
A 1 455 MET 455 718 718 MET MET A . n 
A 1 456 LYS 456 719 719 LYS LYS A . n 
A 1 457 ASP 457 720 720 ASP ASP A . n 
A 1 458 GLY 458 721 721 GLY GLY A . n 
A 1 459 ARG 459 722 722 ARG ARG A . n 
A 1 460 VAL 460 723 723 VAL VAL A . n 
A 1 461 LEU 461 724 724 LEU LEU A . n 
A 1 462 VAL 462 725 725 VAL VAL A . n 
A 1 463 VAL 463 726 726 VAL VAL A . n 
A 1 464 PRO 464 727 727 PRO PRO A . n 
A 1 465 CYS 465 728 728 CYS CYS A . n 
A 1 466 ARG 466 729 729 ARG ARG A . n 
A 1 467 ASN 467 730 730 ASN ASN A . n 
A 1 468 GLN 468 731 731 GLN GLN A . n 
A 1 469 ASP 469 732 732 ASP ASP A . n 
A 1 470 GLU 470 733 733 GLU GLU A . n 
A 1 471 LEU 471 734 734 LEU LEU A . n 
A 1 472 ILE 472 735 735 ILE ILE A . n 
A 1 473 GLY 473 736 736 GLY GLY A . n 
A 1 474 ARG 474 737 737 ARG ARG A . n 
A 1 475 ALA 475 738 738 ALA ALA A . n 
A 1 476 ARG 476 739 739 ARG ARG A . n 
A 1 477 ILE 477 740 740 ILE ILE A . n 
A 1 478 SER 478 741 741 SER SER A . n 
A 1 479 GLN 479 742 742 GLN GLN A . n 
A 1 480 GLY 480 743 743 GLY GLY A . n 
A 1 481 ALA 481 744 744 ALA ALA A . n 
A 1 482 GLY 482 745 745 GLY GLY A . n 
A 1 483 TRP 483 746 746 TRP TRP A . n 
A 1 484 SER 484 747 747 SER SER A . n 
A 1 485 LEU 485 748 748 LEU LEU A . n 
A 1 486 ARG 486 749 749 ARG ARG A . n 
A 1 487 GLU 487 750 750 GLU GLU A . n 
A 1 488 THR 488 751 751 THR THR A . n 
A 1 489 ALA 489 752 752 ALA ALA A . n 
A 1 490 CYS 490 753 753 CYS CYS A . n 
A 1 491 LEU 491 754 754 LEU LEU A . n 
A 1 492 GLY 492 755 755 GLY GLY A . n 
A 1 493 LYS 493 756 756 LYS LYS A . n 
A 1 494 SER 494 757 757 SER SER A . n 
A 1 495 TYR 495 758 758 TYR TYR A . n 
A 1 496 ALA 496 759 759 ALA ALA A . n 
A 1 497 GLN 497 760 760 GLN GLN A . n 
A 1 498 MET 498 761 761 MET MET A . n 
A 1 499 TRP 499 762 762 TRP TRP A . n 
A 1 500 SER 500 763 763 SER SER A . n 
A 1 501 LEU 501 764 764 LEU LEU A . n 
A 1 502 MET 502 765 765 MET MET A . n 
A 1 503 TYR 503 766 766 TYR TYR A . n 
A 1 504 PHE 504 767 767 PHE PHE A . n 
A 1 505 HIS 505 768 768 HIS HIS A . n 
A 1 506 ARG 506 769 769 ARG ARG A . n 
A 1 507 ARG 507 770 770 ARG ARG A . n 
A 1 508 ASP 508 771 771 ASP ASP A . n 
A 1 509 LEU 509 772 772 LEU LEU A . n 
A 1 510 ARG 510 773 773 ARG ARG A . n 
A 1 511 LEU 511 774 774 LEU LEU A . n 
A 1 512 ALA 512 775 775 ALA ALA A . n 
A 1 513 ALA 513 776 776 ALA ALA A . n 
A 1 514 ASN 514 777 777 ASN ASN A . n 
A 1 515 ALA 515 778 778 ALA ALA A . n 
A 1 516 ILE 516 779 779 ILE ILE A . n 
A 1 517 CYS 517 780 780 CYS CYS A . n 
A 1 518 SER 518 781 781 SER SER A . n 
A 1 519 ALA 519 782 782 ALA ALA A . n 
A 1 520 VAL 520 783 783 VAL VAL A . n 
A 1 521 PRO 521 784 784 PRO PRO A . n 
A 1 522 SER 522 785 785 SER SER A . n 
A 1 523 HIS 523 786 786 HIS HIS A . n 
A 1 524 TRP 524 787 787 TRP TRP A . n 
A 1 525 VAL 525 788 788 VAL VAL A . n 
A 1 526 PRO 526 789 789 PRO PRO A . n 
A 1 527 THR 527 790 790 THR THR A . n 
A 1 528 SER 528 791 791 SER SER A . n 
A 1 529 ARG 529 792 792 ARG ARG A . n 
A 1 530 THR 530 793 793 THR THR A . n 
A 1 531 THR 531 794 ?   ?   ?   A . n 
A 1 532 TRP 532 795 ?   ?   ?   A . n 
A 1 533 SER 533 796 ?   ?   ?   A . n 
A 1 534 ILE 534 797 ?   ?   ?   A . n 
A 1 535 HIS 535 798 ?   ?   ?   A . n 
A 1 536 ALA 536 799 799 ALA ALA A . n 
A 1 537 THR 537 800 800 THR THR A . n 
A 1 538 HIS 538 801 801 HIS HIS A . n 
A 1 539 GLU 539 802 802 GLU GLU A . n 
A 1 540 TRP 540 803 803 TRP TRP A . n 
A 1 541 MET 541 804 804 MET MET A . n 
A 1 542 THR 542 805 805 THR THR A . n 
A 1 543 THR 543 806 806 THR THR A . n 
A 1 544 GLU 544 807 807 GLU GLU A . n 
A 1 545 ASP 545 808 808 ASP ASP A . n 
A 1 546 MET 546 809 809 MET MET A . n 
A 1 547 LEU 547 810 810 LEU LEU A . n 
A 1 548 THR 548 811 811 THR THR A . n 
A 1 549 VAL 549 812 812 VAL VAL A . n 
A 1 550 TRP 550 813 813 TRP TRP A . n 
A 1 551 ASN 551 814 814 ASN ASN A . n 
A 1 552 ARG 552 815 815 ARG ARG A . n 
A 1 553 VAL 553 816 816 VAL VAL A . n 
A 1 554 TRP 554 817 817 TRP TRP A . n 
A 1 555 ILE 555 818 818 ILE ILE A . n 
A 1 556 GLN 556 819 819 GLN GLN A . n 
A 1 557 GLU 557 820 820 GLU GLU A . n 
A 1 558 ASN 558 821 821 ASN ASN A . n 
A 1 559 PRO 559 822 822 PRO PRO A . n 
A 1 560 TRP 560 823 823 TRP TRP A . n 
A 1 561 MET 561 824 824 MET MET A . n 
A 1 562 GLU 562 825 825 GLU GLU A . n 
A 1 563 ASP 563 826 826 ASP ASP A . n 
A 1 564 LYS 564 827 827 LYS LYS A . n 
A 1 565 THR 565 828 828 THR THR A . n 
A 1 566 PRO 566 829 829 PRO PRO A . n 
A 1 567 VAL 567 830 830 VAL VAL A . n 
A 1 568 GLU 568 831 831 GLU GLU A . n 
A 1 569 SER 569 832 832 SER SER A . n 
A 1 570 TRP 570 833 833 TRP TRP A . n 
A 1 571 GLU 571 834 834 GLU GLU A . n 
A 1 572 GLU 572 835 835 GLU GLU A . n 
A 1 573 ILE 573 836 836 ILE ILE A . n 
A 1 574 PRO 574 837 837 PRO PRO A . n 
A 1 575 TYR 575 838 838 TYR TYR A . n 
A 1 576 LEU 576 839 839 LEU LEU A . n 
A 1 577 GLY 577 840 840 GLY GLY A . n 
A 1 578 LYS 578 841 841 LYS LYS A . n 
A 1 579 ARG 579 842 842 ARG ARG A . n 
A 1 580 GLU 580 843 843 GLU GLU A . n 
A 1 581 ASP 581 844 844 ASP ASP A . n 
A 1 582 GLN 582 845 845 GLN GLN A . n 
A 1 583 TRP 583 846 846 TRP TRP A . n 
A 1 584 CYS 584 847 847 CYS CYS A . n 
A 1 585 GLY 585 848 848 GLY GLY A . n 
A 1 586 SER 586 849 849 SER SER A . n 
A 1 587 LEU 587 850 850 LEU LEU A . n 
A 1 588 ILE 588 851 851 ILE ILE A . n 
A 1 589 GLY 589 852 852 GLY GLY A . n 
A 1 590 LEU 590 853 853 LEU LEU A . n 
A 1 591 THR 591 854 854 THR THR A . n 
A 1 592 SER 592 855 855 SER SER A . n 
A 1 593 ARG 593 856 856 ARG ARG A . n 
A 1 594 ALA 594 857 857 ALA ALA A . n 
A 1 595 THR 595 858 858 THR THR A . n 
A 1 596 TRP 596 859 859 TRP TRP A . n 
A 1 597 ALA 597 860 860 ALA ALA A . n 
A 1 598 LYS 598 861 861 LYS LYS A . n 
A 1 599 ASN 599 862 862 ASN ASN A . n 
A 1 600 ILE 600 863 863 ILE ILE A . n 
A 1 601 GLN 601 864 864 GLN GLN A . n 
A 1 602 THR 602 865 865 THR THR A . n 
A 1 603 ALA 603 866 866 ALA ALA A . n 
A 1 604 ILE 604 867 867 ILE ILE A . n 
A 1 605 ASN 605 868 868 ASN ASN A . n 
A 1 606 GLN 606 869 869 GLN GLN A . n 
A 1 607 VAL 607 870 870 VAL VAL A . n 
A 1 608 ARG 608 871 871 ARG ARG A . n 
A 1 609 SER 609 872 872 SER SER A . n 
A 1 610 LEU 610 873 873 LEU LEU A . n 
A 1 611 ILE 611 874 874 ILE ILE A . n 
A 1 612 GLY 612 875 875 GLY GLY A . n 
A 1 613 ASN 613 876 876 ASN ASN A . n 
A 1 614 GLU 614 877 877 GLU GLU A . n 
A 1 615 GLU 615 878 878 GLU GLU A . n 
A 1 616 TYR 616 879 879 TYR TYR A . n 
A 1 617 THR 617 880 880 THR THR A . n 
A 1 618 ASP 618 881 881 ASP ASP A . n 
A 1 619 TYR 619 882 882 TYR TYR A . n 
A 1 620 MET 620 883 883 MET MET A . n 
A 1 621 PRO 621 884 884 PRO PRO A . n 
A 1 622 SER 622 885 885 SER SER A . n 
A 1 623 MET 623 886 886 MET MET A . n 
A 1 624 LYS 624 887 887 LYS LYS A . n 
A 1 625 ARG 625 888 888 ARG ARG A . n 
A 1 626 PHE 626 889 889 PHE PHE A . n 
A 1 627 ARG 627 890 890 ARG ARG A . n 
A 1 628 ARG 628 891 891 ARG ARG A . n 
A 1 629 GLU 629 892 ?   ?   ?   A . n 
A 1 630 GLU 630 893 ?   ?   ?   A . n 
A 1 631 GLU 631 894 ?   ?   ?   A . n 
A 1 632 GLU 632 895 ?   ?   ?   A . n 
A 1 633 ALA 633 896 ?   ?   ?   A . n 
A 1 634 GLY 634 897 ?   ?   ?   A . n 
A 1 635 VAL 635 898 ?   ?   ?   A . n 
A 1 636 LEU 636 899 ?   ?   ?   A . n 
A 1 637 TRP 637 900 ?   ?   ?   A . n 
# 
_pdbx_entity_instance_feature.ordinal        1 
_pdbx_entity_instance_feature.comp_id        WHM 
_pdbx_entity_instance_feature.asym_id        ? 
_pdbx_entity_instance_feature.seq_num        ? 
_pdbx_entity_instance_feature.auth_comp_id   WHM 
_pdbx_entity_instance_feature.auth_asym_id   ? 
_pdbx_entity_instance_feature.auth_seq_num   ? 
_pdbx_entity_instance_feature.feature_type   'SUBJECT OF INVESTIGATION' 
_pdbx_entity_instance_feature.details        ? 
# 
loop_
_pdbx_nonpoly_scheme.asym_id 
_pdbx_nonpoly_scheme.entity_id 
_pdbx_nonpoly_scheme.mon_id 
_pdbx_nonpoly_scheme.ndb_seq_num 
_pdbx_nonpoly_scheme.pdb_seq_num 
_pdbx_nonpoly_scheme.auth_seq_num 
_pdbx_nonpoly_scheme.pdb_mon_id 
_pdbx_nonpoly_scheme.auth_mon_id 
_pdbx_nonpoly_scheme.pdb_strand_id 
_pdbx_nonpoly_scheme.pdb_ins_code 
B 2 ZN  1   1001 1001 ZN  ZN  A . 
C 2 ZN  1   1002 1002 ZN  ZN  A . 
D 3 MES 1   1003 1004 MES MES A . 
E 4 DMS 1   1004 1530 DMS DMS A . 
F 4 DMS 1   1005 1601 DMS DMS A . 
G 4 DMS 1   1006 1602 DMS DMS A . 
H 5 PEG 1   1007 1603 PEG PEG A . 
I 6 PO4 1   1008 1604 PO4 PO4 A . 
J 6 PO4 1   1009 1606 PO4 PO4 A . 
K 5 PEG 1   1010 1607 PEG PEG A . 
L 7 WHM 1   1011 1707 WHM LIG A . 
M 8 HOH 1   1101 259  HOH HOH A . 
M 8 HOH 2   1102 58   HOH HOH A . 
M 8 HOH 3   1103 189  HOH HOH A . 
M 8 HOH 4   1104 76   HOH HOH A . 
M 8 HOH 5   1105 191  HOH HOH A . 
M 8 HOH 6   1106 11   HOH HOH A . 
M 8 HOH 7   1107 195  HOH HOH A . 
M 8 HOH 8   1108 152  HOH HOH A . 
M 8 HOH 9   1109 230  HOH HOH A . 
M 8 HOH 10  1110 353  HOH HOH A . 
M 8 HOH 11  1111 341  HOH HOH A . 
M 8 HOH 12  1112 90   HOH HOH A . 
M 8 HOH 13  1113 267  HOH HOH A . 
M 8 HOH 14  1114 96   HOH HOH A . 
M 8 HOH 15  1115 273  HOH HOH A . 
M 8 HOH 16  1116 408  HOH HOH A . 
M 8 HOH 17  1117 125  HOH HOH A . 
M 8 HOH 18  1118 327  HOH HOH A . 
M 8 HOH 19  1119 34   HOH HOH A . 
M 8 HOH 20  1120 185  HOH HOH A . 
M 8 HOH 21  1121 52   HOH HOH A . 
M 8 HOH 22  1122 280  HOH HOH A . 
M 8 HOH 23  1123 148  HOH HOH A . 
M 8 HOH 24  1124 170  HOH HOH A . 
M 8 HOH 25  1125 206  HOH HOH A . 
M 8 HOH 26  1126 92   HOH HOH A . 
M 8 HOH 27  1127 204  HOH HOH A . 
M 8 HOH 28  1128 165  HOH HOH A . 
M 8 HOH 29  1129 167  HOH HOH A . 
M 8 HOH 30  1130 209  HOH HOH A . 
M 8 HOH 31  1131 226  HOH HOH A . 
M 8 HOH 32  1132 214  HOH HOH A . 
M 8 HOH 33  1133 201  HOH HOH A . 
M 8 HOH 34  1134 254  HOH HOH A . 
M 8 HOH 35  1135 153  HOH HOH A . 
M 8 HOH 36  1136 251  HOH HOH A . 
M 8 HOH 37  1137 176  HOH HOH A . 
M 8 HOH 38  1138 7    HOH HOH A . 
M 8 HOH 39  1139 258  HOH HOH A . 
M 8 HOH 40  1140 25   HOH HOH A . 
M 8 HOH 41  1141 217  HOH HOH A . 
M 8 HOH 42  1142 202  HOH HOH A . 
M 8 HOH 43  1143 187  HOH HOH A . 
M 8 HOH 44  1144 199  HOH HOH A . 
M 8 HOH 45  1145 186  HOH HOH A . 
M 8 HOH 46  1146 460  HOH HOH A . 
M 8 HOH 47  1147 117  HOH HOH A . 
M 8 HOH 48  1148 174  HOH HOH A . 
M 8 HOH 49  1149 303  HOH HOH A . 
M 8 HOH 50  1150 60   HOH HOH A . 
M 8 HOH 51  1151 281  HOH HOH A . 
M 8 HOH 52  1152 312  HOH HOH A . 
M 8 HOH 53  1153 363  HOH HOH A . 
M 8 HOH 54  1154 234  HOH HOH A . 
M 8 HOH 55  1155 288  HOH HOH A . 
M 8 HOH 56  1156 16   HOH HOH A . 
M 8 HOH 57  1157 222  HOH HOH A . 
M 8 HOH 58  1158 227  HOH HOH A . 
M 8 HOH 59  1159 207  HOH HOH A . 
M 8 HOH 60  1160 180  HOH HOH A . 
M 8 HOH 61  1161 184  HOH HOH A . 
M 8 HOH 62  1162 243  HOH HOH A . 
M 8 HOH 63  1163 307  HOH HOH A . 
M 8 HOH 64  1164 166  HOH HOH A . 
M 8 HOH 65  1165 197  HOH HOH A . 
M 8 HOH 66  1166 396  HOH HOH A . 
M 8 HOH 67  1167 348  HOH HOH A . 
M 8 HOH 68  1168 249  HOH HOH A . 
M 8 HOH 69  1169 205  HOH HOH A . 
M 8 HOH 70  1170 220  HOH HOH A . 
M 8 HOH 71  1171 177  HOH HOH A . 
M 8 HOH 72  1172 342  HOH HOH A . 
M 8 HOH 73  1173 178  HOH HOH A . 
M 8 HOH 74  1174 317  HOH HOH A . 
M 8 HOH 75  1175 347  HOH HOH A . 
M 8 HOH 76  1176 345  HOH HOH A . 
M 8 HOH 77  1177 216  HOH HOH A . 
M 8 HOH 78  1178 190  HOH HOH A . 
M 8 HOH 79  1179 319  HOH HOH A . 
M 8 HOH 80  1180 395  HOH HOH A . 
M 8 HOH 81  1181 300  HOH HOH A . 
M 8 HOH 82  1182 196  HOH HOH A . 
M 8 HOH 83  1183 188  HOH HOH A . 
M 8 HOH 84  1184 6    HOH HOH A . 
M 8 HOH 85  1185 194  HOH HOH A . 
M 8 HOH 86  1186 236  HOH HOH A . 
M 8 HOH 87  1187 150  HOH HOH A . 
M 8 HOH 88  1188 89   HOH HOH A . 
M 8 HOH 89  1189 144  HOH HOH A . 
M 8 HOH 90  1190 239  HOH HOH A . 
M 8 HOH 91  1191 198  HOH HOH A . 
M 8 HOH 92  1192 179  HOH HOH A . 
M 8 HOH 93  1193 211  HOH HOH A . 
M 8 HOH 94  1194 467  HOH HOH A . 
M 8 HOH 95  1195 3    HOH HOH A . 
M 8 HOH 96  1196 160  HOH HOH A . 
M 8 HOH 97  1197 417  HOH HOH A . 
M 8 HOH 98  1198 112  HOH HOH A . 
M 8 HOH 99  1199 5    HOH HOH A . 
M 8 HOH 100 1200 215  HOH HOH A . 
M 8 HOH 101 1201 392  HOH HOH A . 
M 8 HOH 102 1202 309  HOH HOH A . 
M 8 HOH 103 1203 305  HOH HOH A . 
M 8 HOH 104 1204 250  HOH HOH A . 
M 8 HOH 105 1205 274  HOH HOH A . 
M 8 HOH 106 1206 2    HOH HOH A . 
M 8 HOH 107 1207 37   HOH HOH A . 
M 8 HOH 108 1208 306  HOH HOH A . 
M 8 HOH 109 1209 213  HOH HOH A . 
M 8 HOH 110 1210 296  HOH HOH A . 
M 8 HOH 111 1211 247  HOH HOH A . 
M 8 HOH 112 1212 315  HOH HOH A . 
M 8 HOH 113 1213 256  HOH HOH A . 
M 8 HOH 114 1214 458  HOH HOH A . 
M 8 HOH 115 1215 45   HOH HOH A . 
M 8 HOH 116 1216 122  HOH HOH A . 
M 8 HOH 117 1217 182  HOH HOH A . 
M 8 HOH 118 1218 31   HOH HOH A . 
M 8 HOH 119 1219 292  HOH HOH A . 
M 8 HOH 120 1220 289  HOH HOH A . 
M 8 HOH 121 1221 244  HOH HOH A . 
M 8 HOH 122 1222 223  HOH HOH A . 
M 8 HOH 123 1223 252  HOH HOH A . 
M 8 HOH 124 1224 260  HOH HOH A . 
M 8 HOH 125 1225 183  HOH HOH A . 
M 8 HOH 126 1226 210  HOH HOH A . 
M 8 HOH 127 1227 119  HOH HOH A . 
M 8 HOH 128 1228 225  HOH HOH A . 
M 8 HOH 129 1229 264  HOH HOH A . 
M 8 HOH 130 1230 240  HOH HOH A . 
M 8 HOH 131 1231 245  HOH HOH A . 
M 8 HOH 132 1232 266  HOH HOH A . 
M 8 HOH 133 1233 318  HOH HOH A . 
M 8 HOH 134 1234 231  HOH HOH A . 
M 8 HOH 135 1235 232  HOH HOH A . 
M 8 HOH 136 1236 325  HOH HOH A . 
M 8 HOH 137 1237 265  HOH HOH A . 
M 8 HOH 138 1238 358  HOH HOH A . 
M 8 HOH 139 1239 328  HOH HOH A . 
M 8 HOH 140 1240 277  HOH HOH A . 
M 8 HOH 141 1241 151  HOH HOH A . 
M 8 HOH 142 1242 308  HOH HOH A . 
M 8 HOH 143 1243 218  HOH HOH A . 
M 8 HOH 144 1244 238  HOH HOH A . 
M 8 HOH 145 1245 127  HOH HOH A . 
M 8 HOH 146 1246 333  HOH HOH A . 
M 8 HOH 147 1247 294  HOH HOH A . 
M 8 HOH 148 1248 272  HOH HOH A . 
M 8 HOH 149 1249 221  HOH HOH A . 
M 8 HOH 150 1250 311  HOH HOH A . 
M 8 HOH 151 1251 287  HOH HOH A . 
M 8 HOH 152 1252 418  HOH HOH A . 
M 8 HOH 153 1253 262  HOH HOH A . 
M 8 HOH 154 1254 374  HOH HOH A . 
M 8 HOH 155 1255 268  HOH HOH A . 
M 8 HOH 156 1256 69   HOH HOH A . 
M 8 HOH 157 1257 47   HOH HOH A . 
M 8 HOH 158 1258 356  HOH HOH A . 
M 8 HOH 159 1259 323  HOH HOH A . 
M 8 HOH 160 1260 269  HOH HOH A . 
M 8 HOH 161 1261 320  HOH HOH A . 
M 8 HOH 162 1262 290  HOH HOH A . 
M 8 HOH 163 1263 257  HOH HOH A . 
M 8 HOH 164 1264 233  HOH HOH A . 
M 8 HOH 165 1265 346  HOH HOH A . 
M 8 HOH 166 1266 4    HOH HOH A . 
M 8 HOH 167 1267 279  HOH HOH A . 
M 8 HOH 168 1268 316  HOH HOH A . 
M 8 HOH 169 1269 339  HOH HOH A . 
M 8 HOH 170 1270 143  HOH HOH A . 
M 8 HOH 171 1271 368  HOH HOH A . 
M 8 HOH 172 1272 224  HOH HOH A . 
M 8 HOH 173 1273 285  HOH HOH A . 
M 8 HOH 174 1274 22   HOH HOH A . 
M 8 HOH 175 1275 276  HOH HOH A . 
M 8 HOH 176 1276 30   HOH HOH A . 
M 8 HOH 177 1277 336  HOH HOH A . 
M 8 HOH 178 1278 26   HOH HOH A . 
M 8 HOH 179 1279 246  HOH HOH A . 
M 8 HOH 180 1280 302  HOH HOH A . 
M 8 HOH 181 1281 304  HOH HOH A . 
M 8 HOH 182 1282 38   HOH HOH A . 
M 8 HOH 183 1283 344  HOH HOH A . 
M 8 HOH 184 1284 110  HOH HOH A . 
M 8 HOH 185 1285 219  HOH HOH A . 
M 8 HOH 186 1286 321  HOH HOH A . 
M 8 HOH 187 1287 451  HOH HOH A . 
M 8 HOH 188 1288 235  HOH HOH A . 
M 8 HOH 189 1289 355  HOH HOH A . 
M 8 HOH 190 1290 365  HOH HOH A . 
M 8 HOH 191 1291 270  HOH HOH A . 
M 8 HOH 192 1292 278  HOH HOH A . 
M 8 HOH 193 1293 286  HOH HOH A . 
M 8 HOH 194 1294 29   HOH HOH A . 
M 8 HOH 195 1295 241  HOH HOH A . 
M 8 HOH 196 1296 293  HOH HOH A . 
M 8 HOH 197 1297 261  HOH HOH A . 
M 8 HOH 198 1298 19   HOH HOH A . 
M 8 HOH 199 1299 23   HOH HOH A . 
M 8 HOH 200 1300 343  HOH HOH A . 
M 8 HOH 201 1301 145  HOH HOH A . 
M 8 HOH 202 1302 331  HOH HOH A . 
M 8 HOH 203 1303 352  HOH HOH A . 
M 8 HOH 204 1304 366  HOH HOH A . 
M 8 HOH 205 1305 27   HOH HOH A . 
M 8 HOH 206 1306 62   HOH HOH A . 
M 8 HOH 207 1307 291  HOH HOH A . 
M 8 HOH 208 1308 322  HOH HOH A . 
M 8 HOH 209 1309 389  HOH HOH A . 
M 8 HOH 210 1310 298  HOH HOH A . 
M 8 HOH 211 1311 364  HOH HOH A . 
M 8 HOH 212 1312 39   HOH HOH A . 
M 8 HOH 213 1313 275  HOH HOH A . 
M 8 HOH 214 1314 381  HOH HOH A . 
M 8 HOH 215 1315 380  HOH HOH A . 
M 8 HOH 216 1316 369  HOH HOH A . 
M 8 HOH 217 1317 360  HOH HOH A . 
M 8 HOH 218 1318 338  HOH HOH A . 
M 8 HOH 219 1319 212  HOH HOH A . 
M 8 HOH 220 1320 284  HOH HOH A . 
M 8 HOH 221 1321 334  HOH HOH A . 
M 8 HOH 222 1322 350  HOH HOH A . 
M 8 HOH 223 1323 335  HOH HOH A . 
M 8 HOH 224 1324 42   HOH HOH A . 
M 8 HOH 225 1325 357  HOH HOH A . 
M 8 HOH 226 1326 378  HOH HOH A . 
M 8 HOH 227 1327 104  HOH HOH A . 
M 8 HOH 228 1328 330  HOH HOH A . 
M 8 HOH 229 1329 67   HOH HOH A . 
M 8 HOH 230 1330 175  HOH HOH A . 
M 8 HOH 231 1331 388  HOH HOH A . 
M 8 HOH 232 1332 203  HOH HOH A . 
M 8 HOH 233 1333 399  HOH HOH A . 
M 8 HOH 234 1334 237  HOH HOH A . 
M 8 HOH 235 1335 371  HOH HOH A . 
M 8 HOH 236 1336 15   HOH HOH A . 
M 8 HOH 237 1337 282  HOH HOH A . 
M 8 HOH 238 1338 82   HOH HOH A . 
M 8 HOH 239 1339 33   HOH HOH A . 
M 8 HOH 240 1340 313  HOH HOH A . 
M 8 HOH 241 1341 255  HOH HOH A . 
M 8 HOH 242 1342 70   HOH HOH A . 
M 8 HOH 243 1343 386  HOH HOH A . 
M 8 HOH 244 1344 377  HOH HOH A . 
M 8 HOH 245 1345 18   HOH HOH A . 
M 8 HOH 246 1346 314  HOH HOH A . 
M 8 HOH 247 1347 14   HOH HOH A . 
M 8 HOH 248 1348 349  HOH HOH A . 
M 8 HOH 249 1349 297  HOH HOH A . 
M 8 HOH 250 1350 1    HOH HOH A . 
M 8 HOH 251 1351 100  HOH HOH A . 
M 8 HOH 252 1352 401  HOH HOH A . 
M 8 HOH 253 1353 384  HOH HOH A . 
M 8 HOH 254 1354 383  HOH HOH A . 
M 8 HOH 255 1355 32   HOH HOH A . 
M 8 HOH 256 1356 372  HOH HOH A . 
M 8 HOH 257 1357 375  HOH HOH A . 
M 8 HOH 258 1358 367  HOH HOH A . 
M 8 HOH 259 1359 68   HOH HOH A . 
M 8 HOH 260 1360 326  HOH HOH A . 
M 8 HOH 261 1361 391  HOH HOH A . 
M 8 HOH 262 1362 248  HOH HOH A . 
M 8 HOH 263 1363 263  HOH HOH A . 
M 8 HOH 264 1364 379  HOH HOH A . 
M 8 HOH 265 1365 228  HOH HOH A . 
M 8 HOH 266 1366 56   HOH HOH A . 
M 8 HOH 267 1367 46   HOH HOH A . 
M 8 HOH 268 1368 354  HOH HOH A . 
M 8 HOH 269 1369 24   HOH HOH A . 
M 8 HOH 270 1370 423  HOH HOH A . 
M 8 HOH 271 1371 394  HOH HOH A . 
M 8 HOH 272 1372 376  HOH HOH A . 
M 8 HOH 273 1373 387  HOH HOH A . 
M 8 HOH 274 1374 83   HOH HOH A . 
M 8 HOH 275 1375 137  HOH HOH A . 
M 8 HOH 276 1376 114  HOH HOH A . 
M 8 HOH 277 1377 403  HOH HOH A . 
M 8 HOH 278 1378 410  HOH HOH A . 
M 8 HOH 279 1379 393  HOH HOH A . 
M 8 HOH 280 1380 57   HOH HOH A . 
M 8 HOH 281 1381 402  HOH HOH A . 
M 8 HOH 282 1382 351  HOH HOH A . 
M 8 HOH 283 1383 118  HOH HOH A . 
M 8 HOH 284 1384 136  HOH HOH A . 
M 8 HOH 285 1385 109  HOH HOH A . 
M 8 HOH 286 1386 444  HOH HOH A . 
M 8 HOH 287 1387 404  HOH HOH A . 
M 8 HOH 288 1388 421  HOH HOH A . 
M 8 HOH 289 1389 398  HOH HOH A . 
M 8 HOH 290 1390 405  HOH HOH A . 
M 8 HOH 291 1391 340  HOH HOH A . 
M 8 HOH 292 1392 359  HOH HOH A . 
M 8 HOH 293 1393 390  HOH HOH A . 
M 8 HOH 294 1394 138  HOH HOH A . 
M 8 HOH 295 1395 299  HOH HOH A . 
M 8 HOH 296 1396 310  HOH HOH A . 
M 8 HOH 297 1397 193  HOH HOH A . 
M 8 HOH 298 1398 462  HOH HOH A . 
M 8 HOH 299 1399 406  HOH HOH A . 
M 8 HOH 300 1400 283  HOH HOH A . 
M 8 HOH 301 1401 98   HOH HOH A . 
M 8 HOH 302 1402 111  HOH HOH A . 
M 8 HOH 303 1403 91   HOH HOH A . 
M 8 HOH 304 1404 461  HOH HOH A . 
M 8 HOH 305 1405 411  HOH HOH A . 
M 8 HOH 306 1406 253  HOH HOH A . 
M 8 HOH 307 1407 40   HOH HOH A . 
M 8 HOH 308 1408 13   HOH HOH A . 
M 8 HOH 309 1409 373  HOH HOH A . 
M 8 HOH 310 1410 99   HOH HOH A . 
M 8 HOH 311 1411 295  HOH HOH A . 
M 8 HOH 312 1412 415  HOH HOH A . 
M 8 HOH 313 1413 422  HOH HOH A . 
M 8 HOH 314 1414 101  HOH HOH A . 
M 8 HOH 315 1415 324  HOH HOH A . 
M 8 HOH 316 1416 48   HOH HOH A . 
M 8 HOH 317 1417 385  HOH HOH A . 
M 8 HOH 318 1418 181  HOH HOH A . 
M 8 HOH 319 1419 20   HOH HOH A . 
M 8 HOH 320 1420 50   HOH HOH A . 
M 8 HOH 321 1421 436  HOH HOH A . 
M 8 HOH 322 1422 80   HOH HOH A . 
M 8 HOH 323 1423 431  HOH HOH A . 
M 8 HOH 324 1424 43   HOH HOH A . 
M 8 HOH 325 1425 429  HOH HOH A . 
M 8 HOH 326 1426 454  HOH HOH A . 
M 8 HOH 327 1427 142  HOH HOH A . 
M 8 HOH 328 1428 75   HOH HOH A . 
M 8 HOH 329 1429 97   HOH HOH A . 
M 8 HOH 330 1430 28   HOH HOH A . 
M 8 HOH 331 1431 412  HOH HOH A . 
M 8 HOH 332 1432 427  HOH HOH A . 
M 8 HOH 333 1433 459  HOH HOH A . 
M 8 HOH 334 1434 59   HOH HOH A . 
M 8 HOH 335 1435 332  HOH HOH A . 
M 8 HOH 336 1436 409  HOH HOH A . 
M 8 HOH 337 1437 159  HOH HOH A . 
M 8 HOH 338 1438 439  HOH HOH A . 
M 8 HOH 339 1439 229  HOH HOH A . 
M 8 HOH 340 1440 430  HOH HOH A . 
M 8 HOH 341 1441 154  HOH HOH A . 
M 8 HOH 342 1442 413  HOH HOH A . 
M 8 HOH 343 1443 133  HOH HOH A . 
M 8 HOH 344 1444 200  HOH HOH A . 
M 8 HOH 345 1445 407  HOH HOH A . 
M 8 HOH 346 1446 44   HOH HOH A . 
M 8 HOH 347 1447 464  HOH HOH A . 
M 8 HOH 348 1448 425  HOH HOH A . 
M 8 HOH 349 1449 12   HOH HOH A . 
M 8 HOH 350 1450 134  HOH HOH A . 
M 8 HOH 351 1451 428  HOH HOH A . 
M 8 HOH 352 1452 115  HOH HOH A . 
M 8 HOH 353 1453 54   HOH HOH A . 
M 8 HOH 354 1454 416  HOH HOH A . 
M 8 HOH 355 1455 424  HOH HOH A . 
M 8 HOH 356 1456 41   HOH HOH A . 
M 8 HOH 357 1457 414  HOH HOH A . 
M 8 HOH 358 1458 438  HOH HOH A . 
M 8 HOH 359 1459 102  HOH HOH A . 
M 8 HOH 360 1460 72   HOH HOH A . 
M 8 HOH 361 1461 124  HOH HOH A . 
M 8 HOH 362 1462 61   HOH HOH A . 
M 8 HOH 363 1463 397  HOH HOH A . 
M 8 HOH 364 1464 71   HOH HOH A . 
M 8 HOH 365 1465 466  HOH HOH A . 
M 8 HOH 366 1466 434  HOH HOH A . 
M 8 HOH 367 1467 123  HOH HOH A . 
M 8 HOH 368 1468 157  HOH HOH A . 
M 8 HOH 369 1469 94   HOH HOH A . 
M 8 HOH 370 1470 128  HOH HOH A . 
M 8 HOH 371 1471 452  HOH HOH A . 
M 8 HOH 372 1472 426  HOH HOH A . 
M 8 HOH 373 1473 442  HOH HOH A . 
M 8 HOH 374 1474 51   HOH HOH A . 
M 8 HOH 375 1475 74   HOH HOH A . 
M 8 HOH 376 1476 88   HOH HOH A . 
M 8 HOH 377 1477 435  HOH HOH A . 
M 8 HOH 378 1478 141  HOH HOH A . 
M 8 HOH 379 1479 93   HOH HOH A . 
M 8 HOH 380 1480 437  HOH HOH A . 
M 8 HOH 381 1481 8    HOH HOH A . 
M 8 HOH 382 1482 432  HOH HOH A . 
M 8 HOH 383 1483 105  HOH HOH A . 
M 8 HOH 384 1484 301  HOH HOH A . 
M 8 HOH 385 1485 140  HOH HOH A . 
M 8 HOH 386 1486 53   HOH HOH A . 
M 8 HOH 387 1487 445  HOH HOH A . 
M 8 HOH 388 1488 433  HOH HOH A . 
M 8 HOH 389 1489 172  HOH HOH A . 
M 8 HOH 390 1490 121  HOH HOH A . 
M 8 HOH 391 1491 168  HOH HOH A . 
M 8 HOH 392 1492 447  HOH HOH A . 
M 8 HOH 393 1493 453  HOH HOH A . 
M 8 HOH 394 1494 441  HOH HOH A . 
M 8 HOH 395 1495 55   HOH HOH A . 
M 8 HOH 396 1496 443  HOH HOH A . 
M 8 HOH 397 1497 78   HOH HOH A . 
M 8 HOH 398 1498 449  HOH HOH A . 
M 8 HOH 399 1499 135  HOH HOH A . 
M 8 HOH 400 1500 9    HOH HOH A . 
M 8 HOH 401 1501 448  HOH HOH A . 
M 8 HOH 402 1502 49   HOH HOH A . 
M 8 HOH 403 1503 456  HOH HOH A . 
M 8 HOH 404 1504 64   HOH HOH A . 
M 8 HOH 405 1505 63   HOH HOH A . 
M 8 HOH 406 1506 455  HOH HOH A . 
M 8 HOH 407 1507 95   HOH HOH A . 
M 8 HOH 408 1508 17   HOH HOH A . 
M 8 HOH 409 1509 173  HOH HOH A . 
M 8 HOH 410 1510 130  HOH HOH A . 
M 8 HOH 411 1511 440  HOH HOH A . 
M 8 HOH 412 1512 450  HOH HOH A . 
M 8 HOH 413 1513 73   HOH HOH A . 
M 8 HOH 414 1514 155  HOH HOH A . 
# 
loop_
_pdbx_unobs_or_zero_occ_atoms.id 
_pdbx_unobs_or_zero_occ_atoms.PDB_model_num 
_pdbx_unobs_or_zero_occ_atoms.polymer_flag 
_pdbx_unobs_or_zero_occ_atoms.occupancy_flag 
_pdbx_unobs_or_zero_occ_atoms.auth_asym_id 
_pdbx_unobs_or_zero_occ_atoms.auth_comp_id 
_pdbx_unobs_or_zero_occ_atoms.auth_seq_id 
_pdbx_unobs_or_zero_occ_atoms.PDB_ins_code 
_pdbx_unobs_or_zero_occ_atoms.auth_atom_id 
_pdbx_unobs_or_zero_occ_atoms.label_alt_id 
_pdbx_unobs_or_zero_occ_atoms.label_asym_id 
_pdbx_unobs_or_zero_occ_atoms.label_comp_id 
_pdbx_unobs_or_zero_occ_atoms.label_seq_id 
_pdbx_unobs_or_zero_occ_atoms.label_atom_id 
1 1 Y 1 A THR 344 ? CB  ? A THR 81 CB  
2 1 Y 1 A THR 344 ? OG1 ? A THR 81 OG1 
3 1 Y 1 A THR 344 ? CG2 ? A THR 81 CG2 
# 
loop_
_software.classification 
_software.name 
_software.version 
_software.citation_id 
_software.pdbx_ordinal 
refinement       REFMAC  5.8.0267 ? 1 
refinement       REFMAC5 .        ? 2 
'data scaling'   Aimless .        ? 3 
phasing          PHASER  .        ? 4 
'data reduction' XDS     .        ? 5 
# 
_cell.entry_id           7I2D 
_cell.length_a           82.471 
_cell.length_b           116.817 
_cell.length_c           148.610 
_cell.angle_alpha        90.00 
_cell.angle_beta         90.00 
_cell.angle_gamma        90.00 
_cell.Z_PDB              8 
_cell.pdbx_unique_axis   ? 
# 
_symmetry.entry_id                         7I2D 
_symmetry.space_group_name_H-M             'I 2 2 2' 
_symmetry.pdbx_full_space_group_name_H-M   ? 
_symmetry.cell_setting                     ? 
_symmetry.Int_Tables_number                23 
# 
_exptl.entry_id          7I2D 
_exptl.method            'X-RAY DIFFRACTION' 
_exptl.crystals_number   1 
# 
_exptl_crystal.id                    1 
_exptl_crystal.density_meas          ? 
_exptl_crystal.density_Matthews      2.42 
_exptl_crystal.density_percent_sol   49.22 
_exptl_crystal.description           ? 
# 
_exptl_crystal_grow.crystal_id      1 
_exptl_crystal_grow.method          'VAPOR DIFFUSION, SITTING DROP' 
_exptl_crystal_grow.pH              6.5 
_exptl_crystal_grow.temp            293.15 
_exptl_crystal_grow.pdbx_details    '350 mM Magnesium chloride, 10% PEG 4000, 100 mM MES, pH 6.5' 
_exptl_crystal_grow.temp_details    ? 
_exptl_crystal_grow.pdbx_pH_range   ? 
# 
_diffrn.id                     1 
_diffrn.ambient_temp           100 
_diffrn.crystal_id             1 
_diffrn.ambient_temp_details   ? 
# 
_diffrn_detector.detector               PIXEL 
_diffrn_detector.type                   'DECTRIS EIGER2 XE 9M' 
_diffrn_detector.pdbx_collection_date   2023-08-09 
_diffrn_detector.diffrn_id              1 
_diffrn_detector.details                ? 
# 
_diffrn_radiation.diffrn_id                        1 
_diffrn_radiation.wavelength_id                    1 
_diffrn_radiation.pdbx_diffrn_protocol             'SINGLE WAVELENGTH' 
_diffrn_radiation.pdbx_monochromatic_or_laue_m_l   ? 
_diffrn_radiation.monochromator                    ? 
_diffrn_radiation.pdbx_scattering_type             x-ray 
# 
_diffrn_radiation_wavelength.id           1 
_diffrn_radiation_wavelength.wavelength   0.92124 
_diffrn_radiation_wavelength.wt           1.0 
# 
_diffrn_source.diffrn_id                   1 
_diffrn_source.source                      SYNCHROTRON 
_diffrn_source.type                        'DIAMOND BEAMLINE I04-1' 
_diffrn_source.pdbx_wavelength_list        0.92124 
_diffrn_source.pdbx_synchrotron_site       Diamond 
_diffrn_source.pdbx_synchrotron_beamline   I04-1 
_diffrn_source.pdbx_wavelength             ? 
# 
_reflns.entry_id                     7I2D 
_reflns.pdbx_diffrn_id               1 
_reflns.pdbx_ordinal                 1 
_reflns.d_resolution_low             49.91 
_reflns.d_resolution_high            1.70 
_reflns.number_obs                   78977 
_reflns.percent_possible_obs         100.0 
_reflns.pdbx_Rmerge_I_obs            0.161 
_reflns.pdbx_netI_over_sigmaI        9.7 
_reflns.pdbx_redundancy              13.5 
_reflns.pdbx_Rrim_I_all              0.168 
_reflns.pdbx_Rpim_I_all              0.045 
_reflns.pdbx_CC_half                 0.999 
_reflns.pdbx_number_measured_all     1066551 
_reflns.pdbx_chi_squared             0.47 
_reflns.observed_criterion_sigma_I   ? 
_reflns.observed_criterion_sigma_F   ? 
_reflns.number_all                   ? 
_reflns.pdbx_Rsym_value              ? 
_reflns.B_iso_Wilson_estimate        ? 
_reflns.pdbx_CC_star                 ? 
# 
_reflns_shell.pdbx_diffrn_id              1 
_reflns_shell.pdbx_ordinal                1 
_reflns_shell.d_res_high                  1.70 
_reflns_shell.d_res_low                   1.73 
_reflns_shell.number_measured_all         47213 
_reflns_shell.number_unique_obs           4152 
_reflns_shell.Rmerge_I_obs                4.697 
_reflns_shell.pdbx_chi_squared            0.23 
_reflns_shell.pdbx_redundancy             11.4 
_reflns_shell.percent_possible_obs        99.8 
_reflns_shell.pdbx_netI_over_sigmaI_obs   0.3 
_reflns_shell.pdbx_Rrim_I_all             4.920 
_reflns_shell.pdbx_Rpim_I_all             1.453 
_reflns_shell.pdbx_CC_half                0.332 
_reflns_shell.percent_possible_all        ? 
_reflns_shell.pdbx_Rsym_value             ? 
_reflns_shell.meanI_over_sigI_obs         ? 
_reflns_shell.number_measured_obs         ? 
_reflns_shell.number_unique_all           ? 
_reflns_shell.pdbx_CC_star                ? 
# 
_refine.pdbx_refine_id                           'X-RAY DIFFRACTION' 
_refine.entry_id                                 7I2D 
_refine.pdbx_diffrn_id                           1 
_refine.pdbx_TLS_residual_ADP_flag               ? 
_refine.ls_number_reflns_obs                     74180 
_refine.ls_number_reflns_all                     ? 
_refine.pdbx_ls_sigma_I                          ? 
_refine.pdbx_ls_sigma_F                          ? 
_refine.pdbx_data_cutoff_high_absF               ? 
_refine.pdbx_data_cutoff_low_absF                ? 
_refine.pdbx_data_cutoff_high_rms_absF           ? 
_refine.ls_d_res_low                             49.91 
_refine.ls_d_res_high                            1.70 
_refine.ls_percent_reflns_obs                    98.88 
_refine.ls_R_factor_obs                          0.19891 
_refine.ls_R_factor_all                          ? 
_refine.ls_R_factor_R_work                       0.19730 
_refine.ls_R_factor_R_free                       0.22793 
_refine.ls_R_factor_R_free_error                 ? 
_refine.ls_R_factor_R_free_error_details         ? 
_refine.ls_percent_reflns_R_free                 5.1 
_refine.ls_number_reflns_R_free                  4000 
_refine.ls_number_parameters                     ? 
_refine.ls_number_restraints                     ? 
_refine.occupancy_min                            ? 
_refine.occupancy_max                            ? 
_refine.correlation_coeff_Fo_to_Fc               0.965 
_refine.correlation_coeff_Fo_to_Fc_free          0.956 
_refine.B_iso_mean                               58.560 
_refine.aniso_B[1][1]                            -2.17 
_refine.aniso_B[2][2]                            0.73 
_refine.aniso_B[3][3]                            1.44 
_refine.aniso_B[1][2]                            -0.00 
_refine.aniso_B[1][3]                            0.00 
_refine.aniso_B[2][3]                            -0.00 
_refine.solvent_model_details                    MASK 
_refine.solvent_model_param_ksol                 ? 
_refine.solvent_model_param_bsol                 ? 
_refine.pdbx_solvent_vdw_probe_radii             1.20 
_refine.pdbx_solvent_ion_probe_radii             0.80 
_refine.pdbx_solvent_shrinkage_radii             0.80 
_refine.pdbx_ls_cross_valid_method               THROUGHOUT 
_refine.details                                  'HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS' 
_refine.pdbx_starting_model                      ? 
_refine.pdbx_method_to_determine_struct          'MOLECULAR REPLACEMENT' 
_refine.pdbx_isotropic_thermal_model             ? 
_refine.pdbx_stereochemistry_target_values       'MAXIMUM LIKELIHOOD' 
_refine.pdbx_stereochem_target_val_spec_case     ? 
_refine.pdbx_R_Free_selection_details            RANDOM 
_refine.pdbx_overall_ESU_R                       0.168 
_refine.pdbx_overall_ESU_R_Free                  0.139 
_refine.overall_SU_ML                            0.165 
_refine.pdbx_overall_phase_error                 ? 
_refine.overall_SU_B                             5.904 
_refine.overall_SU_R_Cruickshank_DPI             ? 
_refine.pdbx_overall_SU_R_free_Cruickshank_DPI   ? 
_refine.pdbx_overall_SU_R_Blow_DPI               ? 
_refine.pdbx_overall_SU_R_free_Blow_DPI          ? 
# 
_refine_hist.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_hist.cycle_id                         1 
_refine_hist.pdbx_number_atoms_protein        4680 
_refine_hist.pdbx_number_atoms_nucleic_acid   0 
_refine_hist.pdbx_number_atoms_ligand         65 
_refine_hist.number_atoms_solvent             414 
_refine_hist.number_atoms_total               5159 
_refine_hist.d_res_high                       1.70 
_refine_hist.d_res_low                        49.91 
# 
loop_
_refine_ls_restr.type 
_refine_ls_restr.dev_ideal 
_refine_ls_restr.dev_ideal_target 
_refine_ls_restr.weight 
_refine_ls_restr.number 
_refine_ls_restr.pdbx_refine_id 
_refine_ls_restr.pdbx_restraint_function 
r_bond_refined_d             0.008  0.014  ? 11522 'X-RAY DIFFRACTION' ? 
r_bond_other_d               0.001  0.015  ? 8276  'X-RAY DIFFRACTION' ? 
r_angle_refined_deg          1.479  1.644  ? 12058 'X-RAY DIFFRACTION' ? 
r_angle_other_deg            1.239  1.599  ? 19156 'X-RAY DIFFRACTION' ? 
r_dihedral_angle_1_deg       6.271  5.000  ? 1128  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_2_deg       29.693 21.019 ? 520   'X-RAY DIFFRACTION' ? 
r_dihedral_angle_3_deg       16.784 15.000 ? 1651  'X-RAY DIFFRACTION' ? 
r_dihedral_angle_4_deg       18.098 15.000 ? 86    'X-RAY DIFFRACTION' ? 
r_chiral_restr               0.069  0.200  ? 1087  'X-RAY DIFFRACTION' ? 
r_gen_planes_refined         0.007  0.020  ? 10500 'X-RAY DIFFRACTION' ? 
r_gen_planes_other           0.002  0.020  ? 2248  'X-RAY DIFFRACTION' ? 
r_nbd_refined                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbd_other                  ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_refined              ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_nbtor_other                ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_refined        ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_xyhbond_nbd_other          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_refined          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_metal_ion_other            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_refined       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_vdw_other         ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_refined     ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_hbond_other       ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_refined ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_symmetry_metal_ion_other   ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_mcbond_it                  3.111  6.025  ? 5489  'X-RAY DIFFRACTION' ? 
r_mcbond_other               3.139  6.034  ? 5381  'X-RAY DIFFRACTION' ? 
r_mcangle_it                 5.638  8.429  ? 5416  'X-RAY DIFFRACTION' ? 
r_mcangle_other              5.637  8.430  ? 5417  'X-RAY DIFFRACTION' ? 
r_scbond_it                  3.497  6.768  ? 6031  'X-RAY DIFFRACTION' ? 
r_scbond_other               3.497  6.768  ? 6032  'X-RAY DIFFRACTION' ? 
r_scangle_it                 ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_scangle_other              6.024  9.454  ? 6643  'X-RAY DIFFRACTION' ? 
r_long_range_B_refined       8.672  46.856 ? 8684  'X-RAY DIFFRACTION' ? 
r_long_range_B_other         8.603  46.565 ? 8558  'X-RAY DIFFRACTION' ? 
r_rigid_bond_restr           ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_free            ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
r_sphericity_bonded          ?      ?      ? ?     'X-RAY DIFFRACTION' ? 
# 
_refine_ls_shell.pdbx_refine_id                   'X-RAY DIFFRACTION' 
_refine_ls_shell.pdbx_total_number_of_bins_used   20 
_refine_ls_shell.d_res_high                       1.700 
_refine_ls_shell.d_res_low                        1.744 
_refine_ls_shell.number_reflns_R_work             4796 
_refine_ls_shell.R_factor_R_work                  0.452 
_refine_ls_shell.percent_reflns_obs               86.52 
_refine_ls_shell.R_factor_R_free                  0.481 
_refine_ls_shell.R_factor_R_free_error            ? 
_refine_ls_shell.percent_reflns_R_free            ? 
_refine_ls_shell.number_reflns_R_free             244 
_refine_ls_shell.number_reflns_all                ? 
_refine_ls_shell.R_factor_all                     ? 
_refine_ls_shell.R_factor_obs                     ? 
_refine_ls_shell.number_reflns_obs                ? 
# 
_struct.entry_id                  7I2D 
_struct.title                     
;Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z729352906 (DNV2_NS5A-x0258)
;
_struct.pdbx_model_details        ? 
_struct.pdbx_CASP_flag            ? 
_struct.pdbx_model_type_details   ? 
# 
_struct_keywords.entry_id        7I2D 
_struct_keywords.pdbx_keywords   'VIRAL PROTEIN' 
_struct_keywords.text            
;Diamond Light Source, I04-1, READDI, Dengue Virus, crystallographic fragment screening, PanDDA, XChemExplorer, cluster4x, VIRAL PROTEIN
;
# 
loop_
_struct_asym.id 
_struct_asym.pdbx_blank_PDB_chainid_flag 
_struct_asym.pdbx_modified 
_struct_asym.entity_id 
_struct_asym.details 
A N N 1 ? 
B N N 2 ? 
C N N 2 ? 
D N N 3 ? 
E N N 4 ? 
F N N 4 ? 
G N N 4 ? 
H N N 5 ? 
I N N 6 ? 
J N N 6 ? 
K N N 5 ? 
L N N 7 ? 
M N N 8 ? 
# 
_struct_ref.id                         1 
_struct_ref.db_name                    UNP 
_struct_ref.db_code                    Q91H74_9FLAV 
_struct_ref.pdbx_db_accession          Q91H74 
_struct_ref.pdbx_db_isoform            ? 
_struct_ref.entity_id                  1 
_struct_ref.pdbx_seq_one_letter_code   
;GIESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSASSMVNGVVRLLTKPWDIIPMVTQMAMTD
TTPFGQQRVFKEKVDTRTQEPKEGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDENKWKSAREA
VEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLS
GVEGEGLHKLGYILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEAIFKLTYQNKVVRVQRPTP
RGTVMDIISRRDQRGSGQVVTYGLNTFTNMEAQLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGDDC
VVKPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELIMKDGRVLVVPCRNQDELIGRARISQGAG
WSLRETACLGKSYAQMWSLMYFHRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVWIQENPWME
DKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAINQVRSLIGNEEYTDYMPSMKRFRREEEEAGVLW
;
_struct_ref.pdbx_align_begin           2757 
# 
_struct_ref_seq.align_id                      1 
_struct_ref_seq.ref_id                        1 
_struct_ref_seq.pdbx_PDB_id_code              7I2D 
_struct_ref_seq.pdbx_strand_id                A 
_struct_ref_seq.seq_align_beg                 3 
_struct_ref_seq.pdbx_seq_align_beg_ins_code   ? 
_struct_ref_seq.seq_align_end                 637 
_struct_ref_seq.pdbx_seq_align_end_ins_code   ? 
_struct_ref_seq.pdbx_db_accession             Q91H74 
_struct_ref_seq.db_align_beg                  2757 
_struct_ref_seq.pdbx_db_align_beg_ins_code    ? 
_struct_ref_seq.db_align_end                  3391 
_struct_ref_seq.pdbx_db_align_end_ins_code    ? 
_struct_ref_seq.pdbx_auth_seq_align_beg       266 
_struct_ref_seq.pdbx_auth_seq_align_end       900 
# 
loop_
_struct_ref_seq_dif.align_id 
_struct_ref_seq_dif.pdbx_pdb_id_code 
_struct_ref_seq_dif.mon_id 
_struct_ref_seq_dif.pdbx_pdb_strand_id 
_struct_ref_seq_dif.seq_num 
_struct_ref_seq_dif.pdbx_pdb_ins_code 
_struct_ref_seq_dif.pdbx_seq_db_name 
_struct_ref_seq_dif.pdbx_seq_db_accession_code 
_struct_ref_seq_dif.db_mon_id 
_struct_ref_seq_dif.pdbx_seq_db_seq_num 
_struct_ref_seq_dif.details 
_struct_ref_seq_dif.pdbx_auth_seq_num 
_struct_ref_seq_dif.pdbx_ordinal 
1 7I2D GLY A 1 ? UNP Q91H74 ? ? 'expression tag' 264 1 
1 7I2D PRO A 2 ? UNP Q91H74 ? ? 'expression tag' 265 2 
# 
_pdbx_struct_assembly.id                   1 
_pdbx_struct_assembly.details              author_defined_assembly 
_pdbx_struct_assembly.method_details       ? 
_pdbx_struct_assembly.oligomeric_details   monomeric 
_pdbx_struct_assembly.oligomeric_count     1 
# 
_pdbx_struct_assembly_gen.assembly_id       1 
_pdbx_struct_assembly_gen.oper_expression   1 
_pdbx_struct_assembly_gen.asym_id_list      A,B,C,D,E,F,G,H,I,J,K,L,M 
# 
_pdbx_struct_oper_list.id                   1 
_pdbx_struct_oper_list.type                 'identity operation' 
_pdbx_struct_oper_list.name                 1_555 
_pdbx_struct_oper_list.symmetry_operation   x,y,z 
_pdbx_struct_oper_list.matrix[1][1]         1.0000000000 
_pdbx_struct_oper_list.matrix[1][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[1][3]         0.0000000000 
_pdbx_struct_oper_list.vector[1]            0.0000000000 
_pdbx_struct_oper_list.matrix[2][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[2][2]         1.0000000000 
_pdbx_struct_oper_list.matrix[2][3]         0.0000000000 
_pdbx_struct_oper_list.vector[2]            0.0000000000 
_pdbx_struct_oper_list.matrix[3][1]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][2]         0.0000000000 
_pdbx_struct_oper_list.matrix[3][3]         1.0000000000 
_pdbx_struct_oper_list.vector[3]            0.0000000000 
# 
loop_
_struct_conf.conf_type_id 
_struct_conf.id 
_struct_conf.pdbx_PDB_helix_id 
_struct_conf.beg_label_comp_id 
_struct_conf.beg_label_asym_id 
_struct_conf.beg_label_seq_id 
_struct_conf.pdbx_beg_PDB_ins_code 
_struct_conf.end_label_comp_id 
_struct_conf.end_label_asym_id 
_struct_conf.end_label_seq_id 
_struct_conf.pdbx_end_PDB_ins_code 
_struct_conf.beg_auth_comp_id 
_struct_conf.beg_auth_asym_id 
_struct_conf.beg_auth_seq_id 
_struct_conf.end_auth_comp_id 
_struct_conf.end_auth_asym_id 
_struct_conf.end_auth_seq_id 
_struct_conf.pdbx_PDB_helix_class 
_struct_conf.details 
_struct_conf.pdbx_PDB_helix_length 
HELX_P HELX_P1  AA1 ASN A 10  ? HIS A 25  ? ASN A 273 HIS A 288 1 ? 16 
HELX_P HELX_P2  AA2 GLU A 26  ? TRP A 29  ? GLU A 289 TRP A 292 5 ? 4  
HELX_P HELX_P3  AA3 ASN A 59  ? LEU A 65  ? ASN A 322 LEU A 328 1 ? 7  
HELX_P HELX_P4  AA4 THR A 66  ? ILE A 71  ? THR A 329 ILE A 334 5 ? 6  
HELX_P HELX_P5  AA5 ILE A 72  ? GLN A 77  ? ILE A 335 GLN A 340 1 ? 6  
HELX_P HELX_P6  AA6 MET A 78  ? MET A 80  ? MET A 341 MET A 343 5 ? 3  
HELX_P HELX_P7  AA7 LYS A 104 ? LYS A 124 ? LYS A 367 LYS A 387 1 ? 21 
HELX_P HELX_P8  AA8 THR A 132 ? ARG A 141 ? THR A 395 ARG A 404 1 ? 10 
HELX_P HELX_P9  AA9 SER A 158 ? GLU A 164 ? SER A 421 GLU A 427 1 ? 7  
HELX_P HELX_P10 AB1 ASP A 165 ? GLU A 181 ? ASP A 428 GLU A 444 1 ? 17 
HELX_P HELX_P11 AB2 TRP A 215 ? GLY A 227 ? TRP A 478 GLY A 490 1 ? 13 
HELX_P HELX_P12 AB3 GLY A 227 ? ASP A 232 ? GLY A 490 ASP A 495 1 ? 6  
HELX_P HELX_P13 AB4 SER A 236 ? LEU A 241 ? SER A 499 LEU A 504 1 ? 6  
HELX_P HELX_P14 AB5 GLY A 248 ? LYS A 261 ? GLY A 511 LYS A 524 1 ? 14 
HELX_P HELX_P15 AB6 GLY A 274 ? ILE A 279 ? GLY A 537 ILE A 542 5 ? 6  
HELX_P HELX_P16 AB7 THR A 280 ? MET A 289 ? THR A 543 MET A 552 1 ? 10 
HELX_P HELX_P17 AB8 VAL A 290 ? MET A 294 ? VAL A 553 MET A 557 5 ? 5  
HELX_P HELX_P18 AB9 GLU A 295 ? THR A 309 ? GLU A 558 THR A 572 1 ? 15 
HELX_P HELX_P19 AC1 GLY A 339 ? GLU A 363 ? GLY A 602 GLU A 626 1 ? 25 
HELX_P HELX_P20 AC2 THR A 373 ? SER A 393 ? THR A 636 SER A 656 1 ? 21 
HELX_P HELX_P21 AC3 ASP A 408 ? ALA A 414 ? ASP A 671 ALA A 677 5 ? 7  
HELX_P HELX_P22 AC4 LEU A 415 ? MET A 421 ? LEU A 678 MET A 684 1 ? 7  
HELX_P HELX_P23 AC5 ASP A 439 ? VAL A 443 ? ASP A 702 VAL A 706 5 ? 5  
HELX_P HELX_P24 AC6 ASN A 467 ? ARG A 476 ? ASN A 730 ARG A 739 1 ? 10 
HELX_P HELX_P25 AC7 SER A 484 ? TYR A 503 ? SER A 747 TYR A 766 1 ? 20 
HELX_P HELX_P26 AC8 ARG A 506 ? VAL A 520 ? ARG A 769 VAL A 783 1 ? 15 
HELX_P HELX_P27 AC9 ASP A 545 ? ILE A 555 ? ASP A 808 ILE A 818 1 ? 11 
HELX_P HELX_P28 AD1 SER A 569 ? ILE A 573 ? SER A 832 ILE A 836 5 ? 5  
HELX_P HELX_P29 AD2 GLY A 577 ? CYS A 584 ? GLY A 840 CYS A 847 1 ? 8  
HELX_P HELX_P30 AD3 LEU A 590 ? ASN A 599 ? LEU A 853 ASN A 862 1 ? 10 
HELX_P HELX_P31 AD4 ASN A 599 ? GLY A 612 ? ASN A 862 GLY A 875 1 ? 14 
HELX_P HELX_P32 AD5 TYR A 619 ? ARG A 627 ? TYR A 882 ARG A 890 5 ? 9  
# 
_struct_conf_type.id          HELX_P 
_struct_conf_type.criteria    ? 
_struct_conf_type.reference   ? 
# 
loop_
_struct_conn.id 
_struct_conn.conn_type_id 
_struct_conn.pdbx_leaving_atom_flag 
_struct_conn.pdbx_PDB_id 
_struct_conn.ptnr1_label_asym_id 
_struct_conn.ptnr1_label_comp_id 
_struct_conn.ptnr1_label_seq_id 
_struct_conn.ptnr1_label_atom_id 
_struct_conn.pdbx_ptnr1_label_alt_id 
_struct_conn.pdbx_ptnr1_PDB_ins_code 
_struct_conn.pdbx_ptnr1_standard_comp_id 
_struct_conn.ptnr1_symmetry 
_struct_conn.ptnr2_label_asym_id 
_struct_conn.ptnr2_label_comp_id 
_struct_conn.ptnr2_label_seq_id 
_struct_conn.ptnr2_label_atom_id 
_struct_conn.pdbx_ptnr2_label_alt_id 
_struct_conn.pdbx_ptnr2_PDB_ins_code 
_struct_conn.ptnr1_auth_asym_id 
_struct_conn.ptnr1_auth_comp_id 
_struct_conn.ptnr1_auth_seq_id 
_struct_conn.ptnr2_auth_asym_id 
_struct_conn.ptnr2_auth_comp_id 
_struct_conn.ptnr2_auth_seq_id 
_struct_conn.ptnr2_symmetry 
_struct_conn.pdbx_ptnr3_label_atom_id 
_struct_conn.pdbx_ptnr3_label_seq_id 
_struct_conn.pdbx_ptnr3_label_comp_id 
_struct_conn.pdbx_ptnr3_label_asym_id 
_struct_conn.pdbx_ptnr3_label_alt_id 
_struct_conn.pdbx_ptnr3_PDB_ins_code 
_struct_conn.details 
_struct_conn.pdbx_dist_value 
_struct_conn.pdbx_value_order 
_struct_conn.pdbx_role 
metalc1 metalc ? ? A GLU 175 OE1 ? ? ? 1_555 C ZN . ZN ? ? A GLU 438 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.126 ? ? 
metalc2 metalc ? ? A HIS 179 NE2 ? ? ? 1_555 C ZN . ZN ? ? A HIS 442 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.083 ? ? 
metalc3 metalc ? ? A CYS 184 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 447 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.269 ? ? 
metalc4 metalc ? ? A CYS 187 SG  ? ? ? 1_555 C ZN . ZN ? ? A CYS 450 A ZN 1002 1_555 ? ? ? ? ? ? ? 2.132 ? ? 
metalc5 metalc ? ? A HIS 449 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 712 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.096 ? ? 
metalc6 metalc ? ? A HIS 451 NE2 ? ? ? 1_555 B ZN . ZN ? ? A HIS 714 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.007 ? ? 
metalc7 metalc ? ? A CYS 465 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 728 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.350 ? ? 
metalc8 metalc ? ? A CYS 584 SG  ? ? ? 1_555 B ZN . ZN ? ? A CYS 847 A ZN 1001 1_555 ? ? ? ? ? ? ? 2.316 ? ? 
# 
_struct_conn_type.id          metalc 
_struct_conn_type.criteria    ? 
_struct_conn_type.reference   ? 
# 
loop_
_pdbx_struct_conn_angle.id 
_pdbx_struct_conn_angle.ptnr1_label_atom_id 
_pdbx_struct_conn_angle.ptnr1_label_alt_id 
_pdbx_struct_conn_angle.ptnr1_label_asym_id 
_pdbx_struct_conn_angle.ptnr1_label_comp_id 
_pdbx_struct_conn_angle.ptnr1_label_seq_id 
_pdbx_struct_conn_angle.ptnr1_auth_atom_id 
_pdbx_struct_conn_angle.ptnr1_auth_asym_id 
_pdbx_struct_conn_angle.ptnr1_auth_comp_id 
_pdbx_struct_conn_angle.ptnr1_auth_seq_id 
_pdbx_struct_conn_angle.ptnr1_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr1_symmetry 
_pdbx_struct_conn_angle.ptnr2_label_atom_id 
_pdbx_struct_conn_angle.ptnr2_label_alt_id 
_pdbx_struct_conn_angle.ptnr2_label_asym_id 
_pdbx_struct_conn_angle.ptnr2_label_comp_id 
_pdbx_struct_conn_angle.ptnr2_label_seq_id 
_pdbx_struct_conn_angle.ptnr2_auth_atom_id 
_pdbx_struct_conn_angle.ptnr2_auth_asym_id 
_pdbx_struct_conn_angle.ptnr2_auth_comp_id 
_pdbx_struct_conn_angle.ptnr2_auth_seq_id 
_pdbx_struct_conn_angle.ptnr2_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr2_symmetry 
_pdbx_struct_conn_angle.ptnr3_label_atom_id 
_pdbx_struct_conn_angle.ptnr3_label_alt_id 
_pdbx_struct_conn_angle.ptnr3_label_asym_id 
_pdbx_struct_conn_angle.ptnr3_label_comp_id 
_pdbx_struct_conn_angle.ptnr3_label_seq_id 
_pdbx_struct_conn_angle.ptnr3_auth_atom_id 
_pdbx_struct_conn_angle.ptnr3_auth_asym_id 
_pdbx_struct_conn_angle.ptnr3_auth_comp_id 
_pdbx_struct_conn_angle.ptnr3_auth_seq_id 
_pdbx_struct_conn_angle.ptnr3_PDB_ins_code 
_pdbx_struct_conn_angle.ptnr3_symmetry 
_pdbx_struct_conn_angle.value 
_pdbx_struct_conn_angle.value_esd 
1  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 NE2 ? A HIS 179 ? A HIS 442 ? 1_555 106.0 ? 
2  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 121.7 ? 
3  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 184 ? A CYS 447 ? 1_555 118.5 ? 
4  OE1 ? A GLU 175 ? A GLU 438 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 79.0  ? 
5  NE2 ? A HIS 179 ? A HIS 442 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 112.7 ? 
6  SG  ? A CYS 184 ? A CYS 447 ? 1_555 ZN ? C ZN . ? A ZN 1002 ? 1_555 SG  ? A CYS 187 ? A CYS 450 ? 1_555 112.6 ? 
7  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 103.7 ? 
8  NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 104.7 ? 
9  NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 465 ? A CYS 728 ? 1_555 107.3 ? 
10 NE2 ? A HIS 449 ? A HIS 712 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 110.6 ? 
11 NE2 ? A HIS 451 ? A HIS 714 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 112.9 ? 
12 SG  ? A CYS 465 ? A CYS 728 ? 1_555 ZN ? B ZN . ? A ZN 1001 ? 1_555 SG  ? A CYS 584 ? A CYS 847 ? 1_555 116.6 ? 
# 
loop_
_struct_sheet.id 
_struct_sheet.type 
_struct_sheet.number_strands 
_struct_sheet.details 
AA1 ? 5 ? 
AA2 ? 2 ? 
AA3 ? 2 ? 
AA4 ? 2 ? 
# 
loop_
_struct_sheet_order.sheet_id 
_struct_sheet_order.range_id_1 
_struct_sheet_order.range_id_2 
_struct_sheet_order.offset 
_struct_sheet_order.sense 
AA1 1 2 ? anti-parallel 
AA1 2 3 ? anti-parallel 
AA1 3 4 ? parallel      
AA1 4 5 ? anti-parallel 
AA2 1 2 ? anti-parallel 
AA3 1 2 ? anti-parallel 
AA4 1 2 ? anti-parallel 
# 
loop_
_struct_sheet_range.sheet_id 
_struct_sheet_range.id 
_struct_sheet_range.beg_label_comp_id 
_struct_sheet_range.beg_label_asym_id 
_struct_sheet_range.beg_label_seq_id 
_struct_sheet_range.pdbx_beg_PDB_ins_code 
_struct_sheet_range.end_label_comp_id 
_struct_sheet_range.end_label_asym_id 
_struct_sheet_range.end_label_seq_id 
_struct_sheet_range.pdbx_end_PDB_ins_code 
_struct_sheet_range.beg_auth_comp_id 
_struct_sheet_range.beg_auth_asym_id 
_struct_sheet_range.beg_auth_seq_id 
_struct_sheet_range.end_auth_comp_id 
_struct_sheet_range.end_auth_asym_id 
_struct_sheet_range.end_auth_seq_id 
AA1 1 ALA A 41  ? GLU A 47  ? ALA A 304 GLU A 310 
AA1 2 VAL A 326 ? ARG A 332 ? VAL A 589 ARG A 595 
AA1 3 LYS A 313 ? ARG A 319 ? LYS A 576 ARG A 582 
AA1 4 TYR A 189 ? MET A 191 ? TYR A 452 MET A 454 
AA1 5 TRP A 212 ? TYR A 213 ? TRP A 475 TYR A 476 
AA2 1 SER A 56  ? VAL A 58  ? SER A 319 VAL A 321 
AA2 2 ILE A 477 ? GLN A 479 ? ILE A 740 GLN A 742 
AA3 1 MET A 395 ? SER A 398 ? MET A 658 SER A 661 
AA3 2 ASP A 401 ? VAL A 404 ? ASP A 664 VAL A 667 
AA4 1 HIS A 449 ? ILE A 454 ? HIS A 712 ILE A 717 
AA4 2 VAL A 460 ? CYS A 465 ? VAL A 723 CYS A 728 
# 
loop_
_pdbx_struct_sheet_hbond.sheet_id 
_pdbx_struct_sheet_hbond.range_id_1 
_pdbx_struct_sheet_hbond.range_id_2 
_pdbx_struct_sheet_hbond.range_1_label_atom_id 
_pdbx_struct_sheet_hbond.range_1_label_comp_id 
_pdbx_struct_sheet_hbond.range_1_label_asym_id 
_pdbx_struct_sheet_hbond.range_1_label_seq_id 
_pdbx_struct_sheet_hbond.range_1_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_1_auth_atom_id 
_pdbx_struct_sheet_hbond.range_1_auth_comp_id 
_pdbx_struct_sheet_hbond.range_1_auth_asym_id 
_pdbx_struct_sheet_hbond.range_1_auth_seq_id 
_pdbx_struct_sheet_hbond.range_2_label_atom_id 
_pdbx_struct_sheet_hbond.range_2_label_comp_id 
_pdbx_struct_sheet_hbond.range_2_label_asym_id 
_pdbx_struct_sheet_hbond.range_2_label_seq_id 
_pdbx_struct_sheet_hbond.range_2_PDB_ins_code 
_pdbx_struct_sheet_hbond.range_2_auth_atom_id 
_pdbx_struct_sheet_hbond.range_2_auth_comp_id 
_pdbx_struct_sheet_hbond.range_2_auth_asym_id 
_pdbx_struct_sheet_hbond.range_2_auth_seq_id 
AA1 1 2 N TYR A 46  ? N TYR A 309 O MET A 327 ? O MET A 590 
AA1 2 3 O ASP A 328 ? O ASP A 591 N VAL A 317 ? N VAL A 580 
AA1 3 4 O VAL A 314 ? O VAL A 577 N TYR A 189 ? N TYR A 452 
AA1 4 5 N ASN A 190 ? N ASN A 453 O TYR A 213 ? O TYR A 476 
AA2 1 2 N MET A 57  ? N MET A 320 O SER A 478 ? O SER A 741 
AA3 1 2 N SER A 398 ? N SER A 661 O ASP A 401 ? O ASP A 664 
AA4 1 2 N LEU A 453 ? N LEU A 716 O LEU A 461 ? O LEU A 724 
# 
_pdbx_entry_details.entry_id                   7I2D 
_pdbx_entry_details.compound_details           ? 
_pdbx_entry_details.source_details             ? 
_pdbx_entry_details.nonpolymer_details         ? 
_pdbx_entry_details.sequence_details           ? 
_pdbx_entry_details.has_ligand_of_interest     Y 
_pdbx_entry_details.has_protein_modification   N 
# 
loop_
_pdbx_validate_close_contact.id 
_pdbx_validate_close_contact.PDB_model_num 
_pdbx_validate_close_contact.auth_atom_id_1 
_pdbx_validate_close_contact.auth_asym_id_1 
_pdbx_validate_close_contact.auth_comp_id_1 
_pdbx_validate_close_contact.auth_seq_id_1 
_pdbx_validate_close_contact.PDB_ins_code_1 
_pdbx_validate_close_contact.label_alt_id_1 
_pdbx_validate_close_contact.auth_atom_id_2 
_pdbx_validate_close_contact.auth_asym_id_2 
_pdbx_validate_close_contact.auth_comp_id_2 
_pdbx_validate_close_contact.auth_seq_id_2 
_pdbx_validate_close_contact.PDB_ins_code_2 
_pdbx_validate_close_contact.label_alt_id_2 
_pdbx_validate_close_contact.dist 
1 1 OD1 A ASP 664  ? ? O4 A PO4 1008 ? ? 1.97 
2 1 O   A GLU 653  ? ? OG A SER 656  ? ? 2.12 
3 1 OD1 A ASP 534  ? ? O4 A PO4 1008 ? ? 2.13 
4 1 O   A HOH 1260 ? ? O  A HOH 1277 ? ? 2.19 
# 
loop_
_pdbx_validate_symm_contact.id 
_pdbx_validate_symm_contact.PDB_model_num 
_pdbx_validate_symm_contact.auth_atom_id_1 
_pdbx_validate_symm_contact.auth_asym_id_1 
_pdbx_validate_symm_contact.auth_comp_id_1 
_pdbx_validate_symm_contact.auth_seq_id_1 
_pdbx_validate_symm_contact.PDB_ins_code_1 
_pdbx_validate_symm_contact.label_alt_id_1 
_pdbx_validate_symm_contact.site_symmetry_1 
_pdbx_validate_symm_contact.auth_atom_id_2 
_pdbx_validate_symm_contact.auth_asym_id_2 
_pdbx_validate_symm_contact.auth_comp_id_2 
_pdbx_validate_symm_contact.auth_seq_id_2 
_pdbx_validate_symm_contact.PDB_ins_code_2 
_pdbx_validate_symm_contact.label_alt_id_2 
_pdbx_validate_symm_contact.site_symmetry_2 
_pdbx_validate_symm_contact.dist 
1 1 O A HOH 1160 ? ? 1_555 O A HOH 1160 ? ? 2_445 1.70 
2 1 O A HOH 1320 ? ? 1_555 O A HOH 1378 ? ? 2_545 2.18 
# 
_pdbx_validate_rmsd_angle.id                         1 
_pdbx_validate_rmsd_angle.PDB_model_num              1 
_pdbx_validate_rmsd_angle.auth_atom_id_1             NE 
_pdbx_validate_rmsd_angle.auth_asym_id_1             A 
_pdbx_validate_rmsd_angle.auth_comp_id_1             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_1              739 
_pdbx_validate_rmsd_angle.PDB_ins_code_1             ? 
_pdbx_validate_rmsd_angle.label_alt_id_1             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_2             CZ 
_pdbx_validate_rmsd_angle.auth_asym_id_2             A 
_pdbx_validate_rmsd_angle.auth_comp_id_2             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_2              739 
_pdbx_validate_rmsd_angle.PDB_ins_code_2             ? 
_pdbx_validate_rmsd_angle.label_alt_id_2             ? 
_pdbx_validate_rmsd_angle.auth_atom_id_3             NH1 
_pdbx_validate_rmsd_angle.auth_asym_id_3             A 
_pdbx_validate_rmsd_angle.auth_comp_id_3             ARG 
_pdbx_validate_rmsd_angle.auth_seq_id_3              739 
_pdbx_validate_rmsd_angle.PDB_ins_code_3             ? 
_pdbx_validate_rmsd_angle.label_alt_id_3             ? 
_pdbx_validate_rmsd_angle.angle_value                123.90 
_pdbx_validate_rmsd_angle.angle_target_value         120.30 
_pdbx_validate_rmsd_angle.angle_deviation            3.60 
_pdbx_validate_rmsd_angle.angle_standard_deviation   0.50 
_pdbx_validate_rmsd_angle.linker_flag                N 
# 
loop_
_pdbx_validate_torsion.id 
_pdbx_validate_torsion.PDB_model_num 
_pdbx_validate_torsion.auth_comp_id 
_pdbx_validate_torsion.auth_asym_id 
_pdbx_validate_torsion.auth_seq_id 
_pdbx_validate_torsion.PDB_ins_code 
_pdbx_validate_torsion.label_alt_id 
_pdbx_validate_torsion.phi 
_pdbx_validate_torsion.psi 
1 1 SER A 291 ? ? -160.49 31.53  
2 1 ASP A 360 ? ? -93.09  47.12  
3 1 ASN A 406 ? ? 53.50   70.72  
4 1 LYS A 420 ? ? -76.12  -88.05 
5 1 LEU A 504 ? ? 74.50   -40.48 
6 1 ASN A 575 ? ? -161.78 80.68  
7 1 GLN A 598 ? ? 77.33   160.00 
8 1 HIS A 801 ? A -108.51 70.22  
9 1 HIS A 801 ? B -106.77 65.40  
# 
loop_
_pdbx_struct_special_symmetry.id 
_pdbx_struct_special_symmetry.PDB_model_num 
_pdbx_struct_special_symmetry.auth_asym_id 
_pdbx_struct_special_symmetry.auth_comp_id 
_pdbx_struct_special_symmetry.auth_seq_id 
_pdbx_struct_special_symmetry.PDB_ins_code 
_pdbx_struct_special_symmetry.label_asym_id 
_pdbx_struct_special_symmetry.label_comp_id 
_pdbx_struct_special_symmetry.label_seq_id 
1 1 A MES 1003 ? D MES . 
2 1 A HOH 1193 ? M HOH . 
3 1 A HOH 1234 ? M HOH . 
4 1 A HOH 1435 ? M HOH . 
5 1 A HOH 1458 ? M HOH . 
# 
loop_
_pdbx_distant_solvent_atoms.id 
_pdbx_distant_solvent_atoms.PDB_model_num 
_pdbx_distant_solvent_atoms.auth_atom_id 
_pdbx_distant_solvent_atoms.label_alt_id 
_pdbx_distant_solvent_atoms.auth_asym_id 
_pdbx_distant_solvent_atoms.auth_comp_id 
_pdbx_distant_solvent_atoms.auth_seq_id 
_pdbx_distant_solvent_atoms.PDB_ins_code 
_pdbx_distant_solvent_atoms.neighbor_macromolecule_distance 
_pdbx_distant_solvent_atoms.neighbor_ligand_distance 
1 1 O ? A HOH 1512 ? 5.82 . 
2 1 O ? A HOH 1513 ? 5.94 . 
3 1 O ? A HOH 1514 ? 7.44 . 
# 
loop_
_pdbx_unobs_or_zero_occ_residues.id 
_pdbx_unobs_or_zero_occ_residues.PDB_model_num 
_pdbx_unobs_or_zero_occ_residues.polymer_flag 
_pdbx_unobs_or_zero_occ_residues.occupancy_flag 
_pdbx_unobs_or_zero_occ_residues.auth_asym_id 
_pdbx_unobs_or_zero_occ_residues.auth_comp_id 
_pdbx_unobs_or_zero_occ_residues.auth_seq_id 
_pdbx_unobs_or_zero_occ_residues.PDB_ins_code 
_pdbx_unobs_or_zero_occ_residues.label_asym_id 
_pdbx_unobs_or_zero_occ_residues.label_comp_id 
_pdbx_unobs_or_zero_occ_residues.label_seq_id 
1  1 Y 1 A GLY 264 ? A GLY 1   
2  1 Y 1 A PRO 265 ? A PRO 2   
3  1 Y 1 A GLY 266 ? A GLY 3   
4  1 Y 1 A ILE 267 ? A ILE 4   
5  1 Y 1 A GLU 268 ? A GLU 5   
6  1 Y 1 A SER 269 ? A SER 6   
7  1 Y 1 A GLU 270 ? A GLU 7   
8  1 Y 1 A THR 271 ? A THR 8   
9  1 Y 1 A PRO 272 ? A PRO 9   
10 1 Y 1 A GLN 313 ? A GLN 50  
11 1 Y 1 A THR 314 ? A THR 51  
12 1 Y 1 A GLY 315 ? A GLY 52  
13 1 Y 1 A SER 316 ? A SER 53  
14 1 Y 1 A ASP 345 ? A ASP 82  
15 1 Y 1 A THR 346 ? A THR 83  
16 1 Y 1 A THR 347 ? A THR 84  
17 1 Y 1 A PRO 348 ? A PRO 85  
18 1 Y 1 A PHE 349 ? A PHE 86  
19 1 Y 1 A GLY 350 ? A GLY 87  
20 1 Y 1 A GLN 351 ? A GLN 88  
21 1 Y 1 A GLN 352 ? A GLN 89  
22 1 Y 1 A ARG 353 ? A ARG 90  
23 1 Y 1 A VAL 354 ? A VAL 91  
24 1 Y 1 A PHE 355 ? A PHE 92  
25 1 Y 1 A PHE 413 ? A PHE 150 
26 1 Y 1 A THR 414 ? A THR 151 
27 1 Y 1 A ASP 415 ? A ASP 152 
28 1 Y 1 A GLU 416 ? A GLU 153 
29 1 Y 1 A ASN 417 ? A ASN 154 
30 1 Y 1 A LYS 418 ? A LYS 155 
31 1 Y 1 A GLY 456 ? A GLY 193 
32 1 Y 1 A LYS 457 ? A LYS 194 
33 1 Y 1 A ARG 458 ? A ARG 195 
34 1 Y 1 A GLU 459 ? A GLU 196 
35 1 Y 1 A LYS 460 ? A LYS 197 
36 1 Y 1 A LYS 461 ? A LYS 198 
37 1 Y 1 A LEU 462 ? A LEU 199 
38 1 Y 1 A GLY 463 ? A GLY 200 
39 1 Y 1 A GLU 464 ? A GLU 201 
40 1 Y 1 A PHE 465 ? A PHE 202 
41 1 Y 1 A GLY 466 ? A GLY 203 
42 1 Y 1 A LYS 467 ? A LYS 204 
43 1 Y 1 A ALA 468 ? A ALA 205 
44 1 Y 1 A LYS 469 ? A LYS 206 
45 1 Y 1 A GLY 470 ? A GLY 207 
46 1 Y 1 A SER 471 ? A SER 208 
47 1 Y 1 A ARG 472 ? A ARG 209 
48 1 Y 1 A PRO 585 ? A PRO 322 
49 1 Y 1 A ARG 586 ? A ARG 323 
50 1 Y 1 A GLY 587 ? A GLY 324 
51 1 Y 1 A THR 794 ? A THR 531 
52 1 Y 1 A TRP 795 ? A TRP 532 
53 1 Y 1 A SER 796 ? A SER 533 
54 1 Y 1 A ILE 797 ? A ILE 534 
55 1 Y 1 A HIS 798 ? A HIS 535 
56 1 Y 1 A GLU 892 ? A GLU 629 
57 1 Y 1 A GLU 893 ? A GLU 630 
58 1 Y 1 A GLU 894 ? A GLU 631 
59 1 Y 1 A GLU 895 ? A GLU 632 
60 1 Y 1 A ALA 896 ? A ALA 633 
61 1 Y 1 A GLY 897 ? A GLY 634 
62 1 Y 1 A VAL 898 ? A VAL 635 
63 1 Y 1 A LEU 899 ? A LEU 636 
64 1 Y 1 A TRP 900 ? A TRP 637 
# 
loop_
_chem_comp_atom.comp_id 
_chem_comp_atom.atom_id 
_chem_comp_atom.type_symbol 
_chem_comp_atom.pdbx_aromatic_flag 
_chem_comp_atom.pdbx_stereo_config 
_chem_comp_atom.pdbx_ordinal 
ALA N    N  N N 1   
ALA CA   C  N S 2   
ALA C    C  N N 3   
ALA O    O  N N 4   
ALA CB   C  N N 5   
ALA OXT  O  N N 6   
ALA H    H  N N 7   
ALA H2   H  N N 8   
ALA HA   H  N N 9   
ALA HB1  H  N N 10  
ALA HB2  H  N N 11  
ALA HB3  H  N N 12  
ALA HXT  H  N N 13  
ARG N    N  N N 14  
ARG CA   C  N S 15  
ARG C    C  N N 16  
ARG O    O  N N 17  
ARG CB   C  N N 18  
ARG CG   C  N N 19  
ARG CD   C  N N 20  
ARG NE   N  N N 21  
ARG CZ   C  N N 22  
ARG NH1  N  N N 23  
ARG NH2  N  N N 24  
ARG OXT  O  N N 25  
ARG H    H  N N 26  
ARG H2   H  N N 27  
ARG HA   H  N N 28  
ARG HB2  H  N N 29  
ARG HB3  H  N N 30  
ARG HG2  H  N N 31  
ARG HG3  H  N N 32  
ARG HD2  H  N N 33  
ARG HD3  H  N N 34  
ARG HE   H  N N 35  
ARG HH11 H  N N 36  
ARG HH12 H  N N 37  
ARG HH21 H  N N 38  
ARG HH22 H  N N 39  
ARG HXT  H  N N 40  
ASN N    N  N N 41  
ASN CA   C  N S 42  
ASN C    C  N N 43  
ASN O    O  N N 44  
ASN CB   C  N N 45  
ASN CG   C  N N 46  
ASN OD1  O  N N 47  
ASN ND2  N  N N 48  
ASN OXT  O  N N 49  
ASN H    H  N N 50  
ASN H2   H  N N 51  
ASN HA   H  N N 52  
ASN HB2  H  N N 53  
ASN HB3  H  N N 54  
ASN HD21 H  N N 55  
ASN HD22 H  N N 56  
ASN HXT  H  N N 57  
ASP N    N  N N 58  
ASP CA   C  N S 59  
ASP C    C  N N 60  
ASP O    O  N N 61  
ASP CB   C  N N 62  
ASP CG   C  N N 63  
ASP OD1  O  N N 64  
ASP OD2  O  N N 65  
ASP OXT  O  N N 66  
ASP H    H  N N 67  
ASP H2   H  N N 68  
ASP HA   H  N N 69  
ASP HB2  H  N N 70  
ASP HB3  H  N N 71  
ASP HD2  H  N N 72  
ASP HXT  H  N N 73  
CYS N    N  N N 74  
CYS CA   C  N R 75  
CYS C    C  N N 76  
CYS O    O  N N 77  
CYS CB   C  N N 78  
CYS SG   S  N N 79  
CYS OXT  O  N N 80  
CYS H    H  N N 81  
CYS H2   H  N N 82  
CYS HA   H  N N 83  
CYS HB2  H  N N 84  
CYS HB3  H  N N 85  
CYS HG   H  N N 86  
CYS HXT  H  N N 87  
DMS S    S  N N 88  
DMS O    O  N N 89  
DMS C1   C  N N 90  
DMS C2   C  N N 91  
DMS H11  H  N N 92  
DMS H12  H  N N 93  
DMS H13  H  N N 94  
DMS H21  H  N N 95  
DMS H22  H  N N 96  
DMS H23  H  N N 97  
GLN N    N  N N 98  
GLN CA   C  N S 99  
GLN C    C  N N 100 
GLN O    O  N N 101 
GLN CB   C  N N 102 
GLN CG   C  N N 103 
GLN CD   C  N N 104 
GLN OE1  O  N N 105 
GLN NE2  N  N N 106 
GLN OXT  O  N N 107 
GLN H    H  N N 108 
GLN H2   H  N N 109 
GLN HA   H  N N 110 
GLN HB2  H  N N 111 
GLN HB3  H  N N 112 
GLN HG2  H  N N 113 
GLN HG3  H  N N 114 
GLN HE21 H  N N 115 
GLN HE22 H  N N 116 
GLN HXT  H  N N 117 
GLU N    N  N N 118 
GLU CA   C  N S 119 
GLU C    C  N N 120 
GLU O    O  N N 121 
GLU CB   C  N N 122 
GLU CG   C  N N 123 
GLU CD   C  N N 124 
GLU OE1  O  N N 125 
GLU OE2  O  N N 126 
GLU OXT  O  N N 127 
GLU H    H  N N 128 
GLU H2   H  N N 129 
GLU HA   H  N N 130 
GLU HB2  H  N N 131 
GLU HB3  H  N N 132 
GLU HG2  H  N N 133 
GLU HG3  H  N N 134 
GLU HE2  H  N N 135 
GLU HXT  H  N N 136 
GLY N    N  N N 137 
GLY CA   C  N N 138 
GLY C    C  N N 139 
GLY O    O  N N 140 
GLY OXT  O  N N 141 
GLY H    H  N N 142 
GLY H2   H  N N 143 
GLY HA2  H  N N 144 
GLY HA3  H  N N 145 
GLY HXT  H  N N 146 
HIS N    N  N N 147 
HIS CA   C  N S 148 
HIS C    C  N N 149 
HIS O    O  N N 150 
HIS CB   C  N N 151 
HIS CG   C  Y N 152 
HIS ND1  N  Y N 153 
HIS CD2  C  Y N 154 
HIS CE1  C  Y N 155 
HIS NE2  N  Y N 156 
HIS OXT  O  N N 157 
HIS H    H  N N 158 
HIS H2   H  N N 159 
HIS HA   H  N N 160 
HIS HB2  H  N N 161 
HIS HB3  H  N N 162 
HIS HD1  H  N N 163 
HIS HD2  H  N N 164 
HIS HE1  H  N N 165 
HIS HE2  H  N N 166 
HIS HXT  H  N N 167 
HOH O    O  N N 168 
HOH H1   H  N N 169 
HOH H2   H  N N 170 
ILE N    N  N N 171 
ILE CA   C  N S 172 
ILE C    C  N N 173 
ILE O    O  N N 174 
ILE CB   C  N S 175 
ILE CG1  C  N N 176 
ILE CG2  C  N N 177 
ILE CD1  C  N N 178 
ILE OXT  O  N N 179 
ILE H    H  N N 180 
ILE H2   H  N N 181 
ILE HA   H  N N 182 
ILE HB   H  N N 183 
ILE HG12 H  N N 184 
ILE HG13 H  N N 185 
ILE HG21 H  N N 186 
ILE HG22 H  N N 187 
ILE HG23 H  N N 188 
ILE HD11 H  N N 189 
ILE HD12 H  N N 190 
ILE HD13 H  N N 191 
ILE HXT  H  N N 192 
LEU N    N  N N 193 
LEU CA   C  N S 194 
LEU C    C  N N 195 
LEU O    O  N N 196 
LEU CB   C  N N 197 
LEU CG   C  N N 198 
LEU CD1  C  N N 199 
LEU CD2  C  N N 200 
LEU OXT  O  N N 201 
LEU H    H  N N 202 
LEU H2   H  N N 203 
LEU HA   H  N N 204 
LEU HB2  H  N N 205 
LEU HB3  H  N N 206 
LEU HG   H  N N 207 
LEU HD11 H  N N 208 
LEU HD12 H  N N 209 
LEU HD13 H  N N 210 
LEU HD21 H  N N 211 
LEU HD22 H  N N 212 
LEU HD23 H  N N 213 
LEU HXT  H  N N 214 
LYS N    N  N N 215 
LYS CA   C  N S 216 
LYS C    C  N N 217 
LYS O    O  N N 218 
LYS CB   C  N N 219 
LYS CG   C  N N 220 
LYS CD   C  N N 221 
LYS CE   C  N N 222 
LYS NZ   N  N N 223 
LYS OXT  O  N N 224 
LYS H    H  N N 225 
LYS H2   H  N N 226 
LYS HA   H  N N 227 
LYS HB2  H  N N 228 
LYS HB3  H  N N 229 
LYS HG2  H  N N 230 
LYS HG3  H  N N 231 
LYS HD2  H  N N 232 
LYS HD3  H  N N 233 
LYS HE2  H  N N 234 
LYS HE3  H  N N 235 
LYS HZ1  H  N N 236 
LYS HZ2  H  N N 237 
LYS HZ3  H  N N 238 
LYS HXT  H  N N 239 
MES O1   O  N N 240 
MES C2   C  N N 241 
MES C3   C  N N 242 
MES N4   N  N N 243 
MES C5   C  N N 244 
MES C6   C  N N 245 
MES C7   C  N N 246 
MES C8   C  N N 247 
MES S    S  N N 248 
MES O1S  O  N N 249 
MES O2S  O  N N 250 
MES O3S  O  N N 251 
MES H21  H  N N 252 
MES H22  H  N N 253 
MES H31  H  N N 254 
MES H32  H  N N 255 
MES HN4  H  N N 256 
MES H51  H  N N 257 
MES H52  H  N N 258 
MES H61  H  N N 259 
MES H62  H  N N 260 
MES H71  H  N N 261 
MES H72  H  N N 262 
MES H81  H  N N 263 
MES H82  H  N N 264 
MET N    N  N N 265 
MET CA   C  N S 266 
MET C    C  N N 267 
MET O    O  N N 268 
MET CB   C  N N 269 
MET CG   C  N N 270 
MET SD   S  N N 271 
MET CE   C  N N 272 
MET OXT  O  N N 273 
MET H    H  N N 274 
MET H2   H  N N 275 
MET HA   H  N N 276 
MET HB2  H  N N 277 
MET HB3  H  N N 278 
MET HG2  H  N N 279 
MET HG3  H  N N 280 
MET HE1  H  N N 281 
MET HE2  H  N N 282 
MET HE3  H  N N 283 
MET HXT  H  N N 284 
PEG C1   C  N N 285 
PEG O1   O  N N 286 
PEG C2   C  N N 287 
PEG O2   O  N N 288 
PEG C3   C  N N 289 
PEG C4   C  N N 290 
PEG O4   O  N N 291 
PEG H11  H  N N 292 
PEG H12  H  N N 293 
PEG HO1  H  N N 294 
PEG H21  H  N N 295 
PEG H22  H  N N 296 
PEG H31  H  N N 297 
PEG H32  H  N N 298 
PEG H41  H  N N 299 
PEG H42  H  N N 300 
PEG HO4  H  N N 301 
PHE N    N  N N 302 
PHE CA   C  N S 303 
PHE C    C  N N 304 
PHE O    O  N N 305 
PHE CB   C  N N 306 
PHE CG   C  Y N 307 
PHE CD1  C  Y N 308 
PHE CD2  C  Y N 309 
PHE CE1  C  Y N 310 
PHE CE2  C  Y N 311 
PHE CZ   C  Y N 312 
PHE OXT  O  N N 313 
PHE H    H  N N 314 
PHE H2   H  N N 315 
PHE HA   H  N N 316 
PHE HB2  H  N N 317 
PHE HB3  H  N N 318 
PHE HD1  H  N N 319 
PHE HD2  H  N N 320 
PHE HE1  H  N N 321 
PHE HE2  H  N N 322 
PHE HZ   H  N N 323 
PHE HXT  H  N N 324 
PO4 P    P  N N 325 
PO4 O1   O  N N 326 
PO4 O2   O  N N 327 
PO4 O3   O  N N 328 
PO4 O4   O  N N 329 
PRO N    N  N N 330 
PRO CA   C  N S 331 
PRO C    C  N N 332 
PRO O    O  N N 333 
PRO CB   C  N N 334 
PRO CG   C  N N 335 
PRO CD   C  N N 336 
PRO OXT  O  N N 337 
PRO H    H  N N 338 
PRO HA   H  N N 339 
PRO HB2  H  N N 340 
PRO HB3  H  N N 341 
PRO HG2  H  N N 342 
PRO HG3  H  N N 343 
PRO HD2  H  N N 344 
PRO HD3  H  N N 345 
PRO HXT  H  N N 346 
SER N    N  N N 347 
SER CA   C  N S 348 
SER C    C  N N 349 
SER O    O  N N 350 
SER CB   C  N N 351 
SER OG   O  N N 352 
SER OXT  O  N N 353 
SER H    H  N N 354 
SER H2   H  N N 355 
SER HA   H  N N 356 
SER HB2  H  N N 357 
SER HB3  H  N N 358 
SER HG   H  N N 359 
SER HXT  H  N N 360 
THR N    N  N N 361 
THR CA   C  N S 362 
THR C    C  N N 363 
THR O    O  N N 364 
THR CB   C  N R 365 
THR OG1  O  N N 366 
THR CG2  C  N N 367 
THR OXT  O  N N 368 
THR H    H  N N 369 
THR H2   H  N N 370 
THR HA   H  N N 371 
THR HB   H  N N 372 
THR HG1  H  N N 373 
THR HG21 H  N N 374 
THR HG22 H  N N 375 
THR HG23 H  N N 376 
THR HXT  H  N N 377 
TRP N    N  N N 378 
TRP CA   C  N S 379 
TRP C    C  N N 380 
TRP O    O  N N 381 
TRP CB   C  N N 382 
TRP CG   C  Y N 383 
TRP CD1  C  Y N 384 
TRP CD2  C  Y N 385 
TRP NE1  N  Y N 386 
TRP CE2  C  Y N 387 
TRP CE3  C  Y N 388 
TRP CZ2  C  Y N 389 
TRP CZ3  C  Y N 390 
TRP CH2  C  Y N 391 
TRP OXT  O  N N 392 
TRP H    H  N N 393 
TRP H2   H  N N 394 
TRP HA   H  N N 395 
TRP HB2  H  N N 396 
TRP HB3  H  N N 397 
TRP HD1  H  N N 398 
TRP HE1  H  N N 399 
TRP HE3  H  N N 400 
TRP HZ2  H  N N 401 
TRP HZ3  H  N N 402 
TRP HH2  H  N N 403 
TRP HXT  H  N N 404 
TYR N    N  N N 405 
TYR CA   C  N S 406 
TYR C    C  N N 407 
TYR O    O  N N 408 
TYR CB   C  N N 409 
TYR CG   C  Y N 410 
TYR CD1  C  Y N 411 
TYR CD2  C  Y N 412 
TYR CE1  C  Y N 413 
TYR CE2  C  Y N 414 
TYR CZ   C  Y N 415 
TYR OH   O  N N 416 
TYR OXT  O  N N 417 
TYR H    H  N N 418 
TYR H2   H  N N 419 
TYR HA   H  N N 420 
TYR HB2  H  N N 421 
TYR HB3  H  N N 422 
TYR HD1  H  N N 423 
TYR HD2  H  N N 424 
TYR HE1  H  N N 425 
TYR HE2  H  N N 426 
TYR HH   H  N N 427 
TYR HXT  H  N N 428 
VAL N    N  N N 429 
VAL CA   C  N S 430 
VAL C    C  N N 431 
VAL O    O  N N 432 
VAL CB   C  N N 433 
VAL CG1  C  N N 434 
VAL CG2  C  N N 435 
VAL OXT  O  N N 436 
VAL H    H  N N 437 
VAL H2   H  N N 438 
VAL HA   H  N N 439 
VAL HB   H  N N 440 
VAL HG11 H  N N 441 
VAL HG12 H  N N 442 
VAL HG13 H  N N 443 
VAL HG21 H  N N 444 
VAL HG22 H  N N 445 
VAL HG23 H  N N 446 
VAL HXT  H  N N 447 
WHM C4   C  Y N 448 
WHM C5   C  N N 449 
WHM C6   C  N N 450 
WHM C7   C  N N 451 
WHM C8   C  N N 452 
WHM N    N  N N 453 
WHM C    C  Y N 454 
WHM O    O  N N 455 
WHM C1   C  Y N 456 
WHM C2   C  Y N 457 
WHM C3   C  Y N 458 
WHM C9   C  Y N 459 
WHM F    F  N N 460 
WHM O1   O  N N 461 
WHM S    S  N N 462 
WHM H3   H  N N 463 
WHM H4   H  N N 464 
WHM H5   H  N N 465 
WHM H6   H  N N 466 
WHM H7   H  N N 467 
WHM H8   H  N N 468 
WHM H9   H  N N 469 
WHM H10  H  N N 470 
WHM H    H  N N 471 
WHM H1   H  N N 472 
WHM H2   H  N N 473 
WHM H11  H  N N 474 
ZN  ZN   ZN N N 475 
# 
loop_
_chem_comp_bond.comp_id 
_chem_comp_bond.atom_id_1 
_chem_comp_bond.atom_id_2 
_chem_comp_bond.value_order 
_chem_comp_bond.pdbx_aromatic_flag 
_chem_comp_bond.pdbx_stereo_config 
_chem_comp_bond.pdbx_ordinal 
ALA N   CA   sing N N 1   
ALA N   H    sing N N 2   
ALA N   H2   sing N N 3   
ALA CA  C    sing N N 4   
ALA CA  CB   sing N N 5   
ALA CA  HA   sing N N 6   
ALA C   O    doub N N 7   
ALA C   OXT  sing N N 8   
ALA CB  HB1  sing N N 9   
ALA CB  HB2  sing N N 10  
ALA CB  HB3  sing N N 11  
ALA OXT HXT  sing N N 12  
ARG N   CA   sing N N 13  
ARG N   H    sing N N 14  
ARG N   H2   sing N N 15  
ARG CA  C    sing N N 16  
ARG CA  CB   sing N N 17  
ARG CA  HA   sing N N 18  
ARG C   O    doub N N 19  
ARG C   OXT  sing N N 20  
ARG CB  CG   sing N N 21  
ARG CB  HB2  sing N N 22  
ARG CB  HB3  sing N N 23  
ARG CG  CD   sing N N 24  
ARG CG  HG2  sing N N 25  
ARG CG  HG3  sing N N 26  
ARG CD  NE   sing N N 27  
ARG CD  HD2  sing N N 28  
ARG CD  HD3  sing N N 29  
ARG NE  CZ   sing N N 30  
ARG NE  HE   sing N N 31  
ARG CZ  NH1  sing N N 32  
ARG CZ  NH2  doub N N 33  
ARG NH1 HH11 sing N N 34  
ARG NH1 HH12 sing N N 35  
ARG NH2 HH21 sing N N 36  
ARG NH2 HH22 sing N N 37  
ARG OXT HXT  sing N N 38  
ASN N   CA   sing N N 39  
ASN N   H    sing N N 40  
ASN N   H2   sing N N 41  
ASN CA  C    sing N N 42  
ASN CA  CB   sing N N 43  
ASN CA  HA   sing N N 44  
ASN C   O    doub N N 45  
ASN C   OXT  sing N N 46  
ASN CB  CG   sing N N 47  
ASN CB  HB2  sing N N 48  
ASN CB  HB3  sing N N 49  
ASN CG  OD1  doub N N 50  
ASN CG  ND2  sing N N 51  
ASN ND2 HD21 sing N N 52  
ASN ND2 HD22 sing N N 53  
ASN OXT HXT  sing N N 54  
ASP N   CA   sing N N 55  
ASP N   H    sing N N 56  
ASP N   H2   sing N N 57  
ASP CA  C    sing N N 58  
ASP CA  CB   sing N N 59  
ASP CA  HA   sing N N 60  
ASP C   O    doub N N 61  
ASP C   OXT  sing N N 62  
ASP CB  CG   sing N N 63  
ASP CB  HB2  sing N N 64  
ASP CB  HB3  sing N N 65  
ASP CG  OD1  doub N N 66  
ASP CG  OD2  sing N N 67  
ASP OD2 HD2  sing N N 68  
ASP OXT HXT  sing N N 69  
CYS N   CA   sing N N 70  
CYS N   H    sing N N 71  
CYS N   H2   sing N N 72  
CYS CA  C    sing N N 73  
CYS CA  CB   sing N N 74  
CYS CA  HA   sing N N 75  
CYS C   O    doub N N 76  
CYS C   OXT  sing N N 77  
CYS CB  SG   sing N N 78  
CYS CB  HB2  sing N N 79  
CYS CB  HB3  sing N N 80  
CYS SG  HG   sing N N 81  
CYS OXT HXT  sing N N 82  
DMS S   O    doub N N 83  
DMS S   C1   sing N N 84  
DMS S   C2   sing N N 85  
DMS C1  H11  sing N N 86  
DMS C1  H12  sing N N 87  
DMS C1  H13  sing N N 88  
DMS C2  H21  sing N N 89  
DMS C2  H22  sing N N 90  
DMS C2  H23  sing N N 91  
GLN N   CA   sing N N 92  
GLN N   H    sing N N 93  
GLN N   H2   sing N N 94  
GLN CA  C    sing N N 95  
GLN CA  CB   sing N N 96  
GLN CA  HA   sing N N 97  
GLN C   O    doub N N 98  
GLN C   OXT  sing N N 99  
GLN CB  CG   sing N N 100 
GLN CB  HB2  sing N N 101 
GLN CB  HB3  sing N N 102 
GLN CG  CD   sing N N 103 
GLN CG  HG2  sing N N 104 
GLN CG  HG3  sing N N 105 
GLN CD  OE1  doub N N 106 
GLN CD  NE2  sing N N 107 
GLN NE2 HE21 sing N N 108 
GLN NE2 HE22 sing N N 109 
GLN OXT HXT  sing N N 110 
GLU N   CA   sing N N 111 
GLU N   H    sing N N 112 
GLU N   H2   sing N N 113 
GLU CA  C    sing N N 114 
GLU CA  CB   sing N N 115 
GLU CA  HA   sing N N 116 
GLU C   O    doub N N 117 
GLU C   OXT  sing N N 118 
GLU CB  CG   sing N N 119 
GLU CB  HB2  sing N N 120 
GLU CB  HB3  sing N N 121 
GLU CG  CD   sing N N 122 
GLU CG  HG2  sing N N 123 
GLU CG  HG3  sing N N 124 
GLU CD  OE1  doub N N 125 
GLU CD  OE2  sing N N 126 
GLU OE2 HE2  sing N N 127 
GLU OXT HXT  sing N N 128 
GLY N   CA   sing N N 129 
GLY N   H    sing N N 130 
GLY N   H2   sing N N 131 
GLY CA  C    sing N N 132 
GLY CA  HA2  sing N N 133 
GLY CA  HA3  sing N N 134 
GLY C   O    doub N N 135 
GLY C   OXT  sing N N 136 
GLY OXT HXT  sing N N 137 
HIS N   CA   sing N N 138 
HIS N   H    sing N N 139 
HIS N   H2   sing N N 140 
HIS CA  C    sing N N 141 
HIS CA  CB   sing N N 142 
HIS CA  HA   sing N N 143 
HIS C   O    doub N N 144 
HIS C   OXT  sing N N 145 
HIS CB  CG   sing N N 146 
HIS CB  HB2  sing N N 147 
HIS CB  HB3  sing N N 148 
HIS CG  ND1  sing Y N 149 
HIS CG  CD2  doub Y N 150 
HIS ND1 CE1  doub Y N 151 
HIS ND1 HD1  sing N N 152 
HIS CD2 NE2  sing Y N 153 
HIS CD2 HD2  sing N N 154 
HIS CE1 NE2  sing Y N 155 
HIS CE1 HE1  sing N N 156 
HIS NE2 HE2  sing N N 157 
HIS OXT HXT  sing N N 158 
HOH O   H1   sing N N 159 
HOH O   H2   sing N N 160 
ILE N   CA   sing N N 161 
ILE N   H    sing N N 162 
ILE N   H2   sing N N 163 
ILE CA  C    sing N N 164 
ILE CA  CB   sing N N 165 
ILE CA  HA   sing N N 166 
ILE C   O    doub N N 167 
ILE C   OXT  sing N N 168 
ILE CB  CG1  sing N N 169 
ILE CB  CG2  sing N N 170 
ILE CB  HB   sing N N 171 
ILE CG1 CD1  sing N N 172 
ILE CG1 HG12 sing N N 173 
ILE CG1 HG13 sing N N 174 
ILE CG2 HG21 sing N N 175 
ILE CG2 HG22 sing N N 176 
ILE CG2 HG23 sing N N 177 
ILE CD1 HD11 sing N N 178 
ILE CD1 HD12 sing N N 179 
ILE CD1 HD13 sing N N 180 
ILE OXT HXT  sing N N 181 
LEU N   CA   sing N N 182 
LEU N   H    sing N N 183 
LEU N   H2   sing N N 184 
LEU CA  C    sing N N 185 
LEU CA  CB   sing N N 186 
LEU CA  HA   sing N N 187 
LEU C   O    doub N N 188 
LEU C   OXT  sing N N 189 
LEU CB  CG   sing N N 190 
LEU CB  HB2  sing N N 191 
LEU CB  HB3  sing N N 192 
LEU CG  CD1  sing N N 193 
LEU CG  CD2  sing N N 194 
LEU CG  HG   sing N N 195 
LEU CD1 HD11 sing N N 196 
LEU CD1 HD12 sing N N 197 
LEU CD1 HD13 sing N N 198 
LEU CD2 HD21 sing N N 199 
LEU CD2 HD22 sing N N 200 
LEU CD2 HD23 sing N N 201 
LEU OXT HXT  sing N N 202 
LYS N   CA   sing N N 203 
LYS N   H    sing N N 204 
LYS N   H2   sing N N 205 
LYS CA  C    sing N N 206 
LYS CA  CB   sing N N 207 
LYS CA  HA   sing N N 208 
LYS C   O    doub N N 209 
LYS C   OXT  sing N N 210 
LYS CB  CG   sing N N 211 
LYS CB  HB2  sing N N 212 
LYS CB  HB3  sing N N 213 
LYS CG  CD   sing N N 214 
LYS CG  HG2  sing N N 215 
LYS CG  HG3  sing N N 216 
LYS CD  CE   sing N N 217 
LYS CD  HD2  sing N N 218 
LYS CD  HD3  sing N N 219 
LYS CE  NZ   sing N N 220 
LYS CE  HE2  sing N N 221 
LYS CE  HE3  sing N N 222 
LYS NZ  HZ1  sing N N 223 
LYS NZ  HZ2  sing N N 224 
LYS NZ  HZ3  sing N N 225 
LYS OXT HXT  sing N N 226 
MES O1  C2   sing N N 227 
MES O1  C6   sing N N 228 
MES C2  C3   sing N N 229 
MES C2  H21  sing N N 230 
MES C2  H22  sing N N 231 
MES C3  N4   sing N N 232 
MES C3  H31  sing N N 233 
MES C3  H32  sing N N 234 
MES N4  C5   sing N N 235 
MES N4  C7   sing N N 236 
MES N4  HN4  sing N N 237 
MES C5  C6   sing N N 238 
MES C5  H51  sing N N 239 
MES C5  H52  sing N N 240 
MES C6  H61  sing N N 241 
MES C6  H62  sing N N 242 
MES C7  C8   sing N N 243 
MES C7  H71  sing N N 244 
MES C7  H72  sing N N 245 
MES C8  S    sing N N 246 
MES C8  H81  sing N N 247 
MES C8  H82  sing N N 248 
MES S   O1S  doub N N 249 
MES S   O2S  doub N N 250 
MES S   O3S  sing N N 251 
MET N   CA   sing N N 252 
MET N   H    sing N N 253 
MET N   H2   sing N N 254 
MET CA  C    sing N N 255 
MET CA  CB   sing N N 256 
MET CA  HA   sing N N 257 
MET C   O    doub N N 258 
MET C   OXT  sing N N 259 
MET CB  CG   sing N N 260 
MET CB  HB2  sing N N 261 
MET CB  HB3  sing N N 262 
MET CG  SD   sing N N 263 
MET CG  HG2  sing N N 264 
MET CG  HG3  sing N N 265 
MET SD  CE   sing N N 266 
MET CE  HE1  sing N N 267 
MET CE  HE2  sing N N 268 
MET CE  HE3  sing N N 269 
MET OXT HXT  sing N N 270 
PEG C1  O1   sing N N 271 
PEG C1  C2   sing N N 272 
PEG C1  H11  sing N N 273 
PEG C1  H12  sing N N 274 
PEG O1  HO1  sing N N 275 
PEG C2  O2   sing N N 276 
PEG C2  H21  sing N N 277 
PEG C2  H22  sing N N 278 
PEG O2  C3   sing N N 279 
PEG C3  C4   sing N N 280 
PEG C3  H31  sing N N 281 
PEG C3  H32  sing N N 282 
PEG C4  O4   sing N N 283 
PEG C4  H41  sing N N 284 
PEG C4  H42  sing N N 285 
PEG O4  HO4  sing N N 286 
PHE N   CA   sing N N 287 
PHE N   H    sing N N 288 
PHE N   H2   sing N N 289 
PHE CA  C    sing N N 290 
PHE CA  CB   sing N N 291 
PHE CA  HA   sing N N 292 
PHE C   O    doub N N 293 
PHE C   OXT  sing N N 294 
PHE CB  CG   sing N N 295 
PHE CB  HB2  sing N N 296 
PHE CB  HB3  sing N N 297 
PHE CG  CD1  doub Y N 298 
PHE CG  CD2  sing Y N 299 
PHE CD1 CE1  sing Y N 300 
PHE CD1 HD1  sing N N 301 
PHE CD2 CE2  doub Y N 302 
PHE CD2 HD2  sing N N 303 
PHE CE1 CZ   doub Y N 304 
PHE CE1 HE1  sing N N 305 
PHE CE2 CZ   sing Y N 306 
PHE CE2 HE2  sing N N 307 
PHE CZ  HZ   sing N N 308 
PHE OXT HXT  sing N N 309 
PO4 P   O1   doub N N 310 
PO4 P   O2   sing N N 311 
PO4 P   O3   sing N N 312 
PO4 P   O4   sing N N 313 
PRO N   CA   sing N N 314 
PRO N   CD   sing N N 315 
PRO N   H    sing N N 316 
PRO CA  C    sing N N 317 
PRO CA  CB   sing N N 318 
PRO CA  HA   sing N N 319 
PRO C   O    doub N N 320 
PRO C   OXT  sing N N 321 
PRO CB  CG   sing N N 322 
PRO CB  HB2  sing N N 323 
PRO CB  HB3  sing N N 324 
PRO CG  CD   sing N N 325 
PRO CG  HG2  sing N N 326 
PRO CG  HG3  sing N N 327 
PRO CD  HD2  sing N N 328 
PRO CD  HD3  sing N N 329 
PRO OXT HXT  sing N N 330 
SER N   CA   sing N N 331 
SER N   H    sing N N 332 
SER N   H2   sing N N 333 
SER CA  C    sing N N 334 
SER CA  CB   sing N N 335 
SER CA  HA   sing N N 336 
SER C   O    doub N N 337 
SER C   OXT  sing N N 338 
SER CB  OG   sing N N 339 
SER CB  HB2  sing N N 340 
SER CB  HB3  sing N N 341 
SER OG  HG   sing N N 342 
SER OXT HXT  sing N N 343 
THR N   CA   sing N N 344 
THR N   H    sing N N 345 
THR N   H2   sing N N 346 
THR CA  C    sing N N 347 
THR CA  CB   sing N N 348 
THR CA  HA   sing N N 349 
THR C   O    doub N N 350 
THR C   OXT  sing N N 351 
THR CB  OG1  sing N N 352 
THR CB  CG2  sing N N 353 
THR CB  HB   sing N N 354 
THR OG1 HG1  sing N N 355 
THR CG2 HG21 sing N N 356 
THR CG2 HG22 sing N N 357 
THR CG2 HG23 sing N N 358 
THR OXT HXT  sing N N 359 
TRP N   CA   sing N N 360 
TRP N   H    sing N N 361 
TRP N   H2   sing N N 362 
TRP CA  C    sing N N 363 
TRP CA  CB   sing N N 364 
TRP CA  HA   sing N N 365 
TRP C   O    doub N N 366 
TRP C   OXT  sing N N 367 
TRP CB  CG   sing N N 368 
TRP CB  HB2  sing N N 369 
TRP CB  HB3  sing N N 370 
TRP CG  CD1  doub Y N 371 
TRP CG  CD2  sing Y N 372 
TRP CD1 NE1  sing Y N 373 
TRP CD1 HD1  sing N N 374 
TRP CD2 CE2  doub Y N 375 
TRP CD2 CE3  sing Y N 376 
TRP NE1 CE2  sing Y N 377 
TRP NE1 HE1  sing N N 378 
TRP CE2 CZ2  sing Y N 379 
TRP CE3 CZ3  doub Y N 380 
TRP CE3 HE3  sing N N 381 
TRP CZ2 CH2  doub Y N 382 
TRP CZ2 HZ2  sing N N 383 
TRP CZ3 CH2  sing Y N 384 
TRP CZ3 HZ3  sing N N 385 
TRP CH2 HH2  sing N N 386 
TRP OXT HXT  sing N N 387 
TYR N   CA   sing N N 388 
TYR N   H    sing N N 389 
TYR N   H2   sing N N 390 
TYR CA  C    sing N N 391 
TYR CA  CB   sing N N 392 
TYR CA  HA   sing N N 393 
TYR C   O    doub N N 394 
TYR C   OXT  sing N N 395 
TYR CB  CG   sing N N 396 
TYR CB  HB2  sing N N 397 
TYR CB  HB3  sing N N 398 
TYR CG  CD1  doub Y N 399 
TYR CG  CD2  sing Y N 400 
TYR CD1 CE1  sing Y N 401 
TYR CD1 HD1  sing N N 402 
TYR CD2 CE2  doub Y N 403 
TYR CD2 HD2  sing N N 404 
TYR CE1 CZ   doub Y N 405 
TYR CE1 HE1  sing N N 406 
TYR CE2 CZ   sing Y N 407 
TYR CE2 HE2  sing N N 408 
TYR CZ  OH   sing N N 409 
TYR OH  HH   sing N N 410 
TYR OXT HXT  sing N N 411 
VAL N   CA   sing N N 412 
VAL N   H    sing N N 413 
VAL N   H2   sing N N 414 
VAL CA  C    sing N N 415 
VAL CA  CB   sing N N 416 
VAL CA  HA   sing N N 417 
VAL C   O    doub N N 418 
VAL C   OXT  sing N N 419 
VAL CB  CG1  sing N N 420 
VAL CB  CG2  sing N N 421 
VAL CB  HB   sing N N 422 
VAL CG1 HG11 sing N N 423 
VAL CG1 HG12 sing N N 424 
VAL CG1 HG13 sing N N 425 
VAL CG2 HG21 sing N N 426 
VAL CG2 HG22 sing N N 427 
VAL CG2 HG23 sing N N 428 
VAL OXT HXT  sing N N 429 
WHM F   C    sing N N 430 
WHM C   C1   sing Y N 431 
WHM C1  C2   doub Y N 432 
WHM C2  C3   sing Y N 433 
WHM C3  C4   doub Y N 434 
WHM C4  C5   sing N N 435 
WHM C5  N    sing N N 436 
WHM N   C6   sing N N 437 
WHM C6  C7   sing N N 438 
WHM C7  C8   sing N N 439 
WHM C8  S    sing N N 440 
WHM N   S    sing N N 441 
WHM O   S    doub N N 442 
WHM S   O1   doub N N 443 
WHM C9  C4   sing Y N 444 
WHM C   C9   doub Y N 445 
WHM C5  H3   sing N N 446 
WHM C5  H4   sing N N 447 
WHM C6  H5   sing N N 448 
WHM C6  H6   sing N N 449 
WHM C7  H7   sing N N 450 
WHM C7  H8   sing N N 451 
WHM C8  H9   sing N N 452 
WHM C8  H10  sing N N 453 
WHM C1  H    sing N N 454 
WHM C2  H1   sing N N 455 
WHM C3  H2   sing N N 456 
WHM C9  H11  sing N N 457 
# 
_pdbx_audit_support.ordinal                1 
_pdbx_audit_support.funding_organization   
'National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)' 
_pdbx_audit_support.grant_number           U19AI171292 
_pdbx_audit_support.country                'United States' 
# 
_pdbx_deposit_group.group_id            G_1002341 
_pdbx_deposit_group.group_description   
'Crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_title         
'Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2' 
_pdbx_deposit_group.group_type          'changed state' 
# 
_atom_sites.entry_id                    7I2D 
_atom_sites.fract_transf_matrix[1][1]   0.012125 
_atom_sites.fract_transf_matrix[1][2]   0.000000 
_atom_sites.fract_transf_matrix[1][3]   0.000000 
_atom_sites.fract_transf_matrix[2][1]   -0.000000 
_atom_sites.fract_transf_matrix[2][2]   0.008560 
_atom_sites.fract_transf_matrix[2][3]   0.000000 
_atom_sites.fract_transf_matrix[3][1]   0.000000 
_atom_sites.fract_transf_matrix[3][2]   -0.000000 
_atom_sites.fract_transf_matrix[3][3]   0.006729 
_atom_sites.fract_transf_vector[1]      0.00000 
_atom_sites.fract_transf_vector[2]      0.00000 
_atom_sites.fract_transf_vector[3]      0.00000 
# 
loop_
_atom_type.symbol 
C  
F  
N  
O  
P  
S  
ZN 
# 
loop_
_atom_site.group_PDB 
_atom_site.id 
_atom_site.type_symbol 
_atom_site.label_atom_id 
_atom_site.label_alt_id 
_atom_site.label_comp_id 
_atom_site.label_asym_id 
_atom_site.label_entity_id 
_atom_site.label_seq_id 
_atom_site.pdbx_PDB_ins_code 
_atom_site.Cartn_x 
_atom_site.Cartn_y 
_atom_site.Cartn_z 
_atom_site.occupancy 
_atom_site.B_iso_or_equiv 
_atom_site.pdbx_formal_charge 
_atom_site.auth_seq_id 
_atom_site.auth_comp_id 
_atom_site.auth_asym_id 
_atom_site.auth_atom_id 
_atom_site.pdbx_PDB_model_num 
ATOM   1    N  N   . ASN A 1 10  ? -13.035 -5.737  -11.774 0.50 104.25 ? 273  ASN A N   1 
ATOM   2    C  CA  . ASN A 1 10  ? -12.974 -6.665  -10.607 0.50 103.38 ? 273  ASN A CA  1 
ATOM   3    C  C   . ASN A 1 10  ? -14.341 -6.660  -9.907  0.50 102.21 ? 273  ASN A C   1 
ATOM   4    O  O   . ASN A 1 10  ? -15.306 -7.192  -10.503 0.50 97.05  ? 273  ASN A O   1 
ATOM   5    C  CB  . ASN A 1 10  ? -11.824 -6.300  -9.660  0.50 103.57 ? 273  ASN A CB  1 
ATOM   6    C  CG  . ASN A 1 10  ? -11.252 -7.492  -8.919  0.50 101.74 ? 273  ASN A CG  1 
ATOM   7    O  OD1 . ASN A 1 10  ? -11.957 -8.463  -8.655  0.50 100.60 ? 273  ASN A OD1 1 
ATOM   8    N  ND2 . ASN A 1 10  ? -9.976  -7.429  -8.576  0.50 98.62  ? 273  ASN A ND2 1 
ATOM   9    N  N   . LEU A 1 11  ? -14.422 -6.069  -8.707  0.50 96.11  ? 274  LEU A N   1 
ATOM   10   C  CA  . LEU A 1 11  ? -15.634 -6.082  -7.839  0.50 89.60  ? 274  LEU A CA  1 
ATOM   11   C  C   . LEU A 1 11  ? -16.818 -5.507  -8.623  0.50 82.36  ? 274  LEU A C   1 
ATOM   12   O  O   . LEU A 1 11  ? -17.973 -5.784  -8.253  0.50 78.11  ? 274  LEU A O   1 
ATOM   13   C  CB  . LEU A 1 11  ? -15.353 -5.281  -6.563  0.50 92.58  ? 274  LEU A CB  1 
ATOM   14   C  CG  . LEU A 1 11  ? -16.368 -5.467  -5.434  0.50 94.37  ? 274  LEU A CG  1 
ATOM   15   C  CD1 . LEU A 1 11  ? -15.680 -5.478  -4.076  0.50 94.21  ? 274  LEU A CD1 1 
ATOM   16   C  CD2 . LEU A 1 11  ? -17.447 -4.394  -5.485  0.50 92.81  ? 274  LEU A CD2 1 
ATOM   17   N  N   . ASP A 1 12  ? -16.525 -4.747  -9.679  0.50 77.15  ? 275  ASP A N   1 
ATOM   18   C  CA  . ASP A 1 12  ? -17.514 -4.245  -10.668 0.50 80.92  ? 275  ASP A CA  1 
ATOM   19   C  C   . ASP A 1 12  ? -18.526 -5.355  -10.991 0.50 79.81  ? 275  ASP A C   1 
ATOM   20   O  O   . ASP A 1 12  ? -19.739 -5.122  -10.826 0.50 80.02  ? 275  ASP A O   1 
ATOM   21   C  CB  . ASP A 1 12  ? -16.797 -3.756  -11.931 0.50 82.72  ? 275  ASP A CB  1 
ATOM   22   C  CG  . ASP A 1 12  ? -15.674 -4.675  -12.401 0.50 86.23  ? 275  ASP A CG  1 
ATOM   23   O  OD1 . ASP A 1 12  ? -15.669 -5.859  -11.996 0.50 84.59  ? 275  ASP A OD1 1 
ATOM   24   O  OD2 . ASP A 1 12  ? -14.809 -4.204  -13.169 0.50 88.12  ? 275  ASP A OD2 1 
ATOM   25   N  N   . ILE A 1 13  ? -18.020 -6.525  -11.397 1.00 78.17  ? 276  ILE A N   1 
ATOM   26   C  CA  . ILE A 1 13  ? -18.801 -7.647  -12.024 1.00 65.33  ? 276  ILE A CA  1 
ATOM   27   C  C   . ILE A 1 13  ? -19.218 -8.733  -11.017 1.00 59.87  ? 276  ILE A C   1 
ATOM   28   O  O   . ILE A 1 13  ? -20.309 -9.311  -11.189 1.00 53.85  ? 276  ILE A O   1 
ATOM   29   C  CB  . ILE A 1 13  ? -18.000 -8.226  -13.211 1.00 65.64  ? 276  ILE A CB  1 
ATOM   30   C  CG1 . ILE A 1 13  ? -17.928 -7.216  -14.365 1.00 60.76  ? 276  ILE A CG1 1 
ATOM   31   C  CG2 . ILE A 1 13  ? -18.561 -9.570  -13.672 1.00 65.65  ? 276  ILE A CG2 1 
ATOM   32   C  CD1 . ILE A 1 13  ? -17.011 -7.622  -15.500 1.00 57.29  ? 276  ILE A CD1 1 
ATOM   33   N  N   . ILE A 1 14  ? -18.381 -8.995  -10.006 0.50 60.37  ? 277  ILE A N   1 
ATOM   34   C  CA  . ILE A 1 14  ? -18.591 -10.064 -8.982  0.50 64.21  ? 277  ILE A CA  1 
ATOM   35   C  C   . ILE A 1 14  ? -19.160 -9.473  -7.682  0.50 66.13  ? 277  ILE A C   1 
ATOM   36   O  O   . ILE A 1 14  ? -19.660 -10.273 -6.858  0.50 64.14  ? 277  ILE A O   1 
ATOM   37   C  CB  . ILE A 1 14  ? -17.277 -10.826 -8.717  0.50 65.61  ? 277  ILE A CB  1 
ATOM   38   C  CG1 . ILE A 1 14  ? -16.187 -9.905  -8.164  0.50 66.40  ? 277  ILE A CG1 1 
ATOM   39   C  CG2 . ILE A 1 14  ? -16.814 -11.553 -9.970  0.50 64.73  ? 277  ILE A CG2 1 
ATOM   40   C  CD1 . ILE A 1 14  ? -14.938 -10.634 -7.725  0.50 67.42  ? 277  ILE A CD1 1 
ATOM   41   N  N   . GLY A 1 15  ? -19.085 -8.146  -7.497  1.00 70.70  ? 278  GLY A N   1 
ATOM   42   C  CA  . GLY A 1 15  ? -19.506 -7.459  -6.244  1.00 67.50  ? 278  GLY A CA  1 
ATOM   43   C  C   . GLY A 1 15  ? -20.900 -7.835  -5.762  1.00 66.79  ? 278  GLY A C   1 
ATOM   44   O  O   . GLY A 1 15  ? -21.057 -8.213  -4.587  1.00 71.40  ? 278  GLY A O   1 
ATOM   45   N  N   . LYS A 1 16  ? -21.882 -7.742  -6.664  0.50 68.33  ? 279  LYS A N   1 
ATOM   46   C  CA  . LYS A 1 16  ? -23.324 -8.006  -6.411  0.50 69.09  ? 279  LYS A CA  1 
ATOM   47   C  C   . LYS A 1 16  ? -23.490 -9.409  -5.812  0.50 69.52  ? 279  LYS A C   1 
ATOM   48   O  O   . LYS A 1 16  ? -24.154 -9.532  -4.761  0.50 66.03  ? 279  LYS A O   1 
ATOM   49   C  CB  . LYS A 1 16  ? -24.089 -7.843  -7.729  0.50 73.46  ? 279  LYS A CB  1 
ATOM   50   C  CG  . LYS A 1 16  ? -25.604 -7.747  -7.616  0.50 77.10  ? 279  LYS A CG  1 
ATOM   51   C  CD  . LYS A 1 16  ? -26.273 -7.401  -8.934  0.50 79.40  ? 279  LYS A CD  1 
ATOM   52   C  CE  . LYS A 1 16  ? -27.777 -7.276  -8.826  0.50 80.83  ? 279  LYS A CE  1 
ATOM   53   N  NZ  . LYS A 1 16  ? -28.167 -6.084  -8.037  0.50 82.88  ? 279  LYS A NZ  1 
ATOM   54   N  N   . ARG A 1 17  ? -22.898 -10.420 -6.460  1.00 68.30  ? 280  ARG A N   1 
ATOM   55   C  CA  . ARG A 1 17  ? -22.931 -11.836 -5.992  1.00 67.97  ? 280  ARG A CA  1 
ATOM   56   C  C   . ARG A 1 17  ? -22.318 -11.936 -4.593  1.00 62.42  ? 280  ARG A C   1 
ATOM   57   O  O   . ARG A 1 17  ? -22.831 -12.722 -3.763  1.00 63.08  ? 280  ARG A O   1 
ATOM   58   C  CB  . ARG A 1 17  ? -22.152 -12.752 -6.950  1.00 66.34  ? 280  ARG A CB  1 
ATOM   59   C  CG  . ARG A 1 17  ? -23.014 -13.477 -7.978  1.00 67.88  ? 280  ARG A CG  1 
ATOM   60   C  CD  . ARG A 1 17  ? -22.220 -14.218 -9.044  1.00 54.54  ? 280  ARG A CD  1 
ATOM   61   N  NE  . ARG A 1 17  ? -21.581 -13.260 -9.924  1.00 51.48  ? 280  ARG A NE  1 
ATOM   62   C  CZ  . ARG A 1 17  ? -20.767 -13.559 -10.926 1.00 52.11  ? 280  ARG A CZ  1 
ATOM   63   N  NH1 . ARG A 1 17  ? -20.464 -14.817 -11.216 1.00 48.82  ? 280  ARG A NH1 1 
ATOM   64   N  NH2 . ARG A 1 17  ? -20.292 -12.578 -11.664 1.00 48.16  ? 280  ARG A NH2 1 
ATOM   65   N  N   . ILE A 1 18  ? -21.224 -11.206 -4.367  1.00 68.12  ? 281  ILE A N   1 
ATOM   66   C  CA  . ILE A 1 18  ? -20.499 -11.180 -3.065  1.00 76.47  ? 281  ILE A CA  1 
ATOM   67   C  C   . ILE A 1 18  ? -21.438 -10.511 -2.043  1.00 79.27  ? 281  ILE A C   1 
ATOM   68   O  O   . ILE A 1 18  ? -21.790 -11.174 -1.022  1.00 77.24  ? 281  ILE A O   1 
ATOM   69   C  CB  . ILE A 1 18  ? -19.111 -10.524 -3.254  1.00 82.74  ? 281  ILE A CB  1 
ATOM   70   C  CG1 . ILE A 1 18  ? -18.134 -11.531 -3.865  1.00 82.56  ? 281  ILE A CG1 1 
ATOM   71   C  CG2 . ILE A 1 18  ? -18.554 -9.937  -1.966  1.00 82.68  ? 281  ILE A CG2 1 
ATOM   72   C  CD1 . ILE A 1 18  ? -17.038 -10.903 -4.683  1.00 84.84  ? 281  ILE A CD1 1 
ATOM   73   N  N   . GLU A 1 19  ? -21.865 -9.274  -2.329  0.50 77.99  ? 282  GLU A N   1 
ATOM   74   C  CA  . GLU A 1 19  ? -22.780 -8.462  -1.476  0.50 81.13  ? 282  GLU A CA  1 
ATOM   75   C  C   . GLU A 1 19  ? -23.950 -9.330  -1.000  0.50 76.90  ? 282  GLU A C   1 
ATOM   76   O  O   . GLU A 1 19  ? -24.195 -9.352  0.217   0.50 80.14  ? 282  GLU A O   1 
ATOM   77   C  CB  . GLU A 1 19  ? -23.306 -7.244  -2.238  0.50 84.95  ? 282  GLU A CB  1 
ATOM   78   C  CG  . GLU A 1 19  ? -22.274 -6.143  -2.415  0.50 89.21  ? 282  GLU A CG  1 
ATOM   79   C  CD  . GLU A 1 19  ? -22.579 -5.157  -3.534  0.50 93.32  ? 282  GLU A CD  1 
ATOM   80   O  OE1 . GLU A 1 19  ? -23.776 -4.865  -3.759  0.50 96.93  ? 282  GLU A OE1 1 
ATOM   81   O  OE2 . GLU A 1 19  ? -21.619 -4.689  -4.187  0.50 91.78  ? 282  GLU A OE2 1 
ATOM   82   N  N   . LYS A 1 20  ? -24.626 -10.018 -1.927  1.00 72.68  ? 283  LYS A N   1 
ATOM   83   C  CA  . LYS A 1 20  ? -25.821 -10.846 -1.624  1.00 67.57  ? 283  LYS A CA  1 
ATOM   84   C  C   . LYS A 1 20  ? -25.484 -11.985 -0.668  1.00 69.80  ? 283  LYS A C   1 
ATOM   85   O  O   . LYS A 1 20  ? -26.377 -12.345 0.117   1.00 72.32  ? 283  LYS A O   1 
ATOM   86   C  CB  . LYS A 1 20  ? -26.411 -11.465 -2.891  1.00 68.82  ? 283  LYS A CB  1 
ATOM   87   C  CG  . LYS A 1 20  ? -27.466 -12.539 -2.660  1.00 66.32  ? 283  LYS A CG  1 
ATOM   88   C  CD  . LYS A 1 20  ? -28.413 -12.696 -3.844  1.00 74.60  ? 283  LYS A CD  1 
ATOM   89   C  CE  . LYS A 1 20  ? -29.741 -13.343 -3.506  1.00 68.49  ? 283  LYS A CE  1 
ATOM   90   N  NZ  . LYS A 1 20  ? -29.569 -14.779 -3.196  1.00 70.25  ? 283  LYS A NZ  1 
ATOM   91   N  N   . ILE A 1 21  ? -24.292 -12.579 -0.765  1.00 69.79  ? 284  ILE A N   1 
ATOM   92   C  CA  . ILE A 1 21  ? -23.930 -13.707 0.152   1.00 80.02  ? 284  ILE A CA  1 
ATOM   93   C  C   . ILE A 1 21  ? -23.577 -13.113 1.528   1.00 76.37  ? 284  ILE A C   1 
ATOM   94   O  O   . ILE A 1 21  ? -24.013 -13.690 2.545   1.00 68.56  ? 284  ILE A O   1 
ATOM   95   C  CB  . ILE A 1 21  ? -22.798 -14.601 -0.403  1.00 82.59  ? 284  ILE A CB  1 
ATOM   96   C  CG1 . ILE A 1 21  ? -23.145 -15.210 -1.764  1.00 82.17  ? 284  ILE A CG1 1 
ATOM   97   C  CG2 . ILE A 1 21  ? -22.417 -15.688 0.601   1.00 79.42  ? 284  ILE A CG2 1 
ATOM   98   C  CD1 . ILE A 1 21  ? -21.921 -15.615 -2.581  1.00 75.71  ? 284  ILE A CD1 1 
ATOM   99   N  N   . LYS A 1 22  ? -22.814 -12.014 1.557   1.00 77.00  ? 285  LYS A N   1 
ATOM   100  C  CA  . LYS A 1 22  ? -22.463 -11.264 2.797   1.00 88.50  ? 285  LYS A CA  1 
ATOM   101  C  C   . LYS A 1 22  ? -23.727 -11.040 3.650   1.00 87.03  ? 285  LYS A C   1 
ATOM   102  O  O   . LYS A 1 22  ? -23.721 -11.453 4.823   1.00 92.61  ? 285  LYS A O   1 
ATOM   103  C  CB  . LYS A 1 22  ? -21.747 -9.966  2.412   1.00 97.17  ? 285  LYS A CB  1 
ATOM   104  C  CG  . LYS A 1 22  ? -21.161 -9.164  3.564   1.00 104.65 ? 285  LYS A CG  1 
ATOM   105  C  CD  . LYS A 1 22  ? -20.414 -7.924  3.111   1.00 108.22 ? 285  LYS A CD  1 
ATOM   106  C  CE  . LYS A 1 22  ? -19.985 -7.045  4.270   1.00 115.46 ? 285  LYS A CE  1 
ATOM   107  N  NZ  . LYS A 1 22  ? -19.868 -5.622  3.869   1.00 114.64 ? 285  LYS A NZ  1 
ATOM   108  N  N   . GLN A 1 23  ? -24.753 -10.423 3.069   1.00 85.84  ? 286  GLN A N   1 
ATOM   109  C  CA  . GLN A 1 23  ? -26.022 -10.159 3.795   1.00 87.85  ? 286  GLN A CA  1 
ATOM   110  C  C   . GLN A 1 23  ? -26.637 -11.458 4.329   1.00 86.37  ? 286  GLN A C   1 
ATOM   111  O  O   . GLN A 1 23  ? -27.036 -11.461 5.500   1.00 103.21 ? 286  GLN A O   1 
ATOM   112  C  CB  . GLN A 1 23  ? -26.996 -9.443  2.861   1.00 86.74  ? 286  GLN A CB  1 
ATOM   113  C  CG  . GLN A 1 23  ? -26.430 -8.148  2.295   1.00 91.53  ? 286  GLN A CG  1 
ATOM   114  C  CD  . GLN A 1 23  ? -27.280 -7.569  1.191   1.00 99.13  ? 286  GLN A CD  1 
ATOM   115  O  OE1 . GLN A 1 23  ? -28.310 -8.123  0.816   1.00 109.45 ? 286  GLN A OE1 1 
ATOM   116  N  NE2 . GLN A 1 23  ? -26.844 -6.440  0.655   1.00 101.24 ? 286  GLN A NE2 1 
ATOM   117  N  N   . GLU A 1 24  ? -26.732 -12.510 3.518   0.50 83.58  ? 287  GLU A N   1 
ATOM   118  C  CA  . GLU A 1 24  ? -27.436 -13.742 3.970   0.50 86.62  ? 287  GLU A CA  1 
ATOM   119  C  C   . GLU A 1 24  ? -26.702 -14.356 5.164   0.50 89.85  ? 287  GLU A C   1 
ATOM   120  O  O   . GLU A 1 24  ? -27.269 -15.260 5.805   0.50 87.84  ? 287  GLU A O   1 
ATOM   121  C  CB  . GLU A 1 24  ? -27.554 -14.739 2.818   0.50 88.37  ? 287  GLU A CB  1 
ATOM   122  C  CG  . GLU A 1 24  ? -28.347 -14.202 1.642   0.50 88.82  ? 287  GLU A CG  1 
ATOM   123  C  CD  . GLU A 1 24  ? -28.292 -15.063 0.393   0.50 88.64  ? 287  GLU A CD  1 
ATOM   124  O  OE1 . GLU A 1 24  ? -27.414 -15.945 0.320   0.50 84.83  ? 287  GLU A OE1 1 
ATOM   125  O  OE2 . GLU A 1 24  ? -29.132 -14.850 -0.502  0.50 83.33  ? 287  GLU A OE2 1 
ATOM   126  N  N   . HIS A 1 25  ? -25.484 -13.889 5.437   1.00 94.53  ? 288  HIS A N   1 
ATOM   127  C  CA  . HIS A 1 25  ? -24.696 -14.409 6.585   1.00 102.84 ? 288  HIS A CA  1 
ATOM   128  C  C   . HIS A 1 25  ? -24.093 -13.226 7.352   1.00 112.92 ? 288  HIS A C   1 
ATOM   129  O  O   . HIS A 1 25  ? -22.937 -13.341 7.802   1.00 116.55 ? 288  HIS A O   1 
ATOM   130  C  CB  . HIS A 1 25  ? -23.652 -15.412 6.077   1.00 95.50  ? 288  HIS A CB  1 
ATOM   131  C  CG  . HIS A 1 25  ? -24.215 -16.497 5.224   1.00 89.13  ? 288  HIS A CG  1 
ATOM   132  N  ND1 . HIS A 1 25  ? -24.786 -17.633 5.758   1.00 96.24  ? 288  HIS A ND1 1 
ATOM   133  C  CD2 . HIS A 1 25  ? -24.288 -16.631 3.884   1.00 78.69  ? 288  HIS A CD2 1 
ATOM   134  C  CE1 . HIS A 1 25  ? -25.194 -18.417 4.783   1.00 87.07  ? 288  HIS A CE1 1 
ATOM   135  N  NE2 . HIS A 1 25  ? -24.900 -17.825 3.624   1.00 77.29  ? 288  HIS A NE2 1 
ATOM   136  N  N   . GLU A 1 26  ? -24.852 -12.140 7.512   0.50 114.14 ? 289  GLU A N   1 
ATOM   137  C  CA  . GLU A 1 26  ? -24.311 -10.914 8.162   0.50 116.12 ? 289  GLU A CA  1 
ATOM   138  C  C   . GLU A 1 26  ? -23.819 -11.244 9.573   0.50 116.43 ? 289  GLU A C   1 
ATOM   139  O  O   . GLU A 1 26  ? -22.952 -10.509 10.077  0.50 114.85 ? 289  GLU A O   1 
ATOM   140  C  CB  . GLU A 1 26  ? -25.386 -9.828  8.223   0.50 113.63 ? 289  GLU A CB  1 
ATOM   141  C  CG  . GLU A 1 26  ? -24.839 -8.447  8.533   0.50 111.70 ? 289  GLU A CG  1 
ATOM   142  C  CD  . GLU A 1 26  ? -24.177 -7.745  7.359   0.50 110.91 ? 289  GLU A CD  1 
ATOM   143  O  OE1 . GLU A 1 26  ? -23.226 -6.976  7.595   0.50 108.09 ? 289  GLU A OE1 1 
ATOM   144  O  OE2 . GLU A 1 26  ? -24.624 -7.956  6.214   0.50 108.53 ? 289  GLU A OE2 1 
ATOM   145  N  N   . THR A 1 27  ? -24.341 -12.312 10.181  0.50 113.58 ? 290  THR A N   1 
ATOM   146  C  CA  . THR A 1 27  ? -23.985 -12.611 11.592  0.50 111.99 ? 290  THR A CA  1 
ATOM   147  C  C   . THR A 1 27  ? -22.815 -13.598 11.669  0.50 106.11 ? 290  THR A C   1 
ATOM   148  O  O   . THR A 1 27  ? -22.700 -14.264 12.712  0.50 105.77 ? 290  THR A O   1 
ATOM   149  C  CB  . THR A 1 27  ? -25.196 -13.158 12.358  0.50 113.95 ? 290  THR A CB  1 
ATOM   150  O  OG1 . THR A 1 27  ? -25.569 -14.400 11.762  0.50 117.80 ? 290  THR A OG1 1 
ATOM   151  C  CG2 . THR A 1 27  ? -26.373 -12.208 12.349  0.50 111.86 ? 290  THR A CG2 1 
ATOM   152  N  N   . SER A 1 28  ? -21.988 -13.692 10.621  0.50 96.78  ? 291  SER A N   1 
ATOM   153  C  CA  . SER A 1 28  ? -20.792 -14.575 10.694  0.50 86.68  ? 291  SER A CA  1 
ATOM   154  C  C   . SER A 1 28  ? -19.753 -14.189 9.637   0.50 78.18  ? 291  SER A C   1 
ATOM   155  O  O   . SER A 1 28  ? -19.027 -15.088 9.187   0.50 69.61  ? 291  SER A O   1 
ATOM   156  C  CB  . SER A 1 28  ? -21.193 -16.015 10.546  0.50 86.46  ? 291  SER A CB  1 
ATOM   157  O  OG  . SER A 1 28  ? -22.058 -16.418 11.596  0.50 88.73  ? 291  SER A OG  1 
ATOM   158  N  N   . TRP A 1 29  ? -19.659 -12.909 9.276   0.50 75.03  ? 292  TRP A N   1 
ATOM   159  C  CA  . TRP A 1 29  ? -18.747 -12.522 8.164   0.50 77.94  ? 292  TRP A CA  1 
ATOM   160  C  C   . TRP A 1 29  ? -17.315 -12.329 8.676   0.50 78.86  ? 292  TRP A C   1 
ATOM   161  O  O   . TRP A 1 29  ? -16.852 -11.176 8.716   0.50 82.07  ? 292  TRP A O   1 
ATOM   162  C  CB  . TRP A 1 29  ? -19.277 -11.279 7.439   0.50 74.07  ? 292  TRP A CB  1 
ATOM   163  C  CG  . TRP A 1 29  ? -18.677 -11.060 6.084   0.50 75.65  ? 292  TRP A CG  1 
ATOM   164  C  CD1 . TRP A 1 29  ? -17.893 -10.014 5.690   0.50 75.90  ? 292  TRP A CD1 1 
ATOM   165  C  CD2 . TRP A 1 29  ? -18.810 -11.913 4.932   0.50 72.59  ? 292  TRP A CD2 1 
ATOM   166  N  NE1 . TRP A 1 29  ? -17.533 -10.155 4.377   0.50 73.58  ? 292  TRP A NE1 1 
ATOM   167  C  CE2 . TRP A 1 29  ? -18.080 -11.311 3.886   0.50 74.41  ? 292  TRP A CE2 1 
ATOM   168  C  CE3 . TRP A 1 29  ? -19.472 -13.119 4.682   0.50 72.06  ? 292  TRP A CE3 1 
ATOM   169  C  CZ2 . TRP A 1 29  ? -17.996 -11.877 2.615   0.50 71.62  ? 292  TRP A CZ2 1 
ATOM   170  C  CZ3 . TRP A 1 29  ? -19.388 -13.678 3.427   0.50 70.36  ? 292  TRP A CZ3 1 
ATOM   171  C  CH2 . TRP A 1 29  ? -18.660 -13.064 2.409   0.50 70.08  ? 292  TRP A CH2 1 
ATOM   172  N  N   . HIS A 1 30  ? -16.634 -13.427 9.015   0.50 80.17  ? 293  HIS A N   1 
ATOM   173  C  CA  . HIS A 1 30  ? -15.239 -13.344 9.521   0.50 78.73  ? 293  HIS A CA  1 
ATOM   174  C  C   . HIS A 1 30  ? -14.254 -13.248 8.353   0.50 82.31  ? 293  HIS A C   1 
ATOM   175  O  O   . HIS A 1 30  ? -14.293 -14.130 7.488   0.50 82.21  ? 293  HIS A O   1 
ATOM   176  C  CB  . HIS A 1 30  ? -14.930 -14.523 10.450  0.50 75.88  ? 293  HIS A CB  1 
ATOM   177  C  CG  . HIS A 1 30  ? -15.194 -15.869 9.871   0.50 70.99  ? 293  HIS A CG  1 
ATOM   178  N  ND1 . HIS A 1 30  ? -16.467 -16.388 9.764   0.50 68.03  ? 293  HIS A ND1 1 
ATOM   179  C  CD2 . HIS A 1 30  ? -14.354 -16.819 9.408   0.50 69.75  ? 293  HIS A CD2 1 
ATOM   180  C  CE1 . HIS A 1 30  ? -16.403 -17.593 9.239   0.50 71.65  ? 293  HIS A CE1 1 
ATOM   181  N  NE2 . HIS A 1 30  ? -15.118 -17.881 9.010   0.50 70.79  ? 293  HIS A NE2 1 
ATOM   182  N  N   . TYR A 1 31  ? -13.422 -12.203 8.329   0.50 86.34  ? 294  TYR A N   1 
ATOM   183  C  CA  . TYR A 1 31  ? -12.385 -12.057 7.274   0.50 89.65  ? 294  TYR A CA  1 
ATOM   184  C  C   . TYR A 1 31  ? -11.095 -12.725 7.753   0.50 91.66  ? 294  TYR A C   1 
ATOM   185  O  O   . TYR A 1 31  ? -10.167 -11.999 8.155   0.50 93.49  ? 294  TYR A O   1 
ATOM   186  C  CB  . TYR A 1 31  ? -12.147 -10.580 6.963   0.50 94.25  ? 294  TYR A CB  1 
ATOM   187  C  CG  . TYR A 1 31  ? -11.215 -10.323 5.807   0.50 103.70 ? 294  TYR A CG  1 
ATOM   188  C  CD1 . TYR A 1 31  ? -9.942  -9.817  6.011   0.50 106.67 ? 294  TYR A CD1 1 
ATOM   189  C  CD2 . TYR A 1 31  ? -11.604 -10.592 4.505   0.50 108.25 ? 294  TYR A CD2 1 
ATOM   190  C  CE1 . TYR A 1 31  ? -9.082  -9.579  4.952   0.50 108.17 ? 294  TYR A CE1 1 
ATOM   191  C  CE2 . TYR A 1 31  ? -10.756 -10.358 3.436   0.50 106.72 ? 294  TYR A CE2 1 
ATOM   192  C  CZ  . TYR A 1 31  ? -9.490  -9.851  3.660   0.50 106.90 ? 294  TYR A CZ  1 
ATOM   193  O  OH  . TYR A 1 31  ? -8.649  -9.622  2.610   0.50 102.74 ? 294  TYR A OH  1 
ATOM   194  N  N   . ASP A 1 32  ? -11.032 -14.057 7.698   0.50 92.77  ? 295  ASP A N   1 
ATOM   195  C  CA  . ASP A 1 32  ? -9.851  -14.799 8.220   0.50 92.71  ? 295  ASP A CA  1 
ATOM   196  C  C   . ASP A 1 32  ? -8.563  -14.281 7.573   0.50 97.07  ? 295  ASP A C   1 
ATOM   197  O  O   . ASP A 1 32  ? -8.522  -14.187 6.332   0.50 95.57  ? 295  ASP A O   1 
ATOM   198  C  CB  . ASP A 1 32  ? -10.013 -16.307 8.014   0.50 87.08  ? 295  ASP A CB  1 
ATOM   199  C  CG  . ASP A 1 32  ? -8.947  -17.125 8.716   0.50 83.22  ? 295  ASP A CG  1 
ATOM   200  O  OD1 . ASP A 1 32  ? -8.083  -16.517 9.375   0.50 81.01  ? 295  ASP A OD1 1 
ATOM   201  O  OD2 . ASP A 1 32  ? -8.995  -18.365 8.605   0.50 82.27  ? 295  ASP A OD2 1 
ATOM   202  N  N   . GLN A 1 33  ? -7.555  -13.954 8.387   0.50 96.59  ? 296  GLN A N   1 
ATOM   203  C  CA  . GLN A 1 33  ? -6.244  -13.520 7.839   0.50 98.41  ? 296  GLN A CA  1 
ATOM   204  C  C   . GLN A 1 33  ? -5.371  -14.767 7.703   0.50 98.51  ? 296  GLN A C   1 
ATOM   205  O  O   . GLN A 1 33  ? -4.269  -14.657 7.135   0.50 99.27  ? 296  GLN A O   1 
ATOM   206  C  CB  . GLN A 1 33  ? -5.598  -12.471 8.746   0.50 98.75  ? 296  GLN A CB  1 
ATOM   207  C  CG  . GLN A 1 33  ? -6.322  -11.132 8.746   0.50 99.09  ? 296  GLN A CG  1 
ATOM   208  C  CD  . GLN A 1 33  ? -6.142  -10.380 7.451   0.50 100.68 ? 296  GLN A CD  1 
ATOM   209  O  OE1 . GLN A 1 33  ? -5.545  -10.875 6.498   0.50 103.32 ? 296  GLN A OE1 1 
ATOM   210  N  NE2 . GLN A 1 33  ? -6.658  -9.162  7.409   0.50 100.28 ? 296  GLN A NE2 1 
ATOM   211  N  N   . ASP A 1 34  ? -5.855  -15.900 8.214   0.50 96.88  ? 297  ASP A N   1 
ATOM   212  C  CA  . ASP A 1 34  ? -5.114  -17.181 8.090   0.50 97.31  ? 297  ASP A CA  1 
ATOM   213  C  C   . ASP A 1 34  ? -5.613  -17.901 6.835   0.50 99.54  ? 297  ASP A C   1 
ATOM   214  O  O   . ASP A 1 34  ? -5.487  -19.140 6.782   0.50 102.17 ? 297  ASP A O   1 
ATOM   215  C  CB  . ASP A 1 34  ? -5.280  -18.026 9.354   0.50 94.63  ? 297  ASP A CB  1 
ATOM   216  C  CG  . ASP A 1 34  ? -4.765  -17.338 10.606  0.50 93.75  ? 297  ASP A CG  1 
ATOM   217  O  OD1 . ASP A 1 34  ? -5.091  -17.814 11.710  0.50 89.38  ? 297  ASP A OD1 1 
ATOM   218  O  OD2 . ASP A 1 34  ? -4.038  -16.336 10.467  0.50 94.03  ? 297  ASP A OD2 1 
ATOM   219  N  N   . HIS A 1 35  ? -6.155  -17.151 5.869   0.50 97.65  ? 298  HIS A N   1 
ATOM   220  C  CA  . HIS A 1 35  ? -6.713  -17.744 4.621   0.50 89.49  ? 298  HIS A CA  1 
ATOM   221  C  C   . HIS A 1 35  ? -5.569  -18.287 3.767   0.50 87.25  ? 298  HIS A C   1 
ATOM   222  O  O   . HIS A 1 35  ? -4.582  -17.594 3.525   0.50 85.81  ? 298  HIS A O   1 
ATOM   223  C  CB  . HIS A 1 35  ? -7.604  -16.731 3.878   0.50 85.44  ? 298  HIS A CB  1 
ATOM   224  C  CG  . HIS A 1 35  ? -6.872  -15.716 3.060   0.50 81.03  ? 298  HIS A CG  1 
ATOM   225  N  ND1 . HIS A 1 35  ? -6.920  -14.362 3.345   0.50 78.98  ? 298  HIS A ND1 1 
ATOM   226  C  CD2 . HIS A 1 35  ? -6.113  -15.840 1.949   0.50 78.58  ? 298  HIS A CD2 1 
ATOM   227  C  CE1 . HIS A 1 35  ? -6.206  -13.700 2.457   0.50 77.14  ? 298  HIS A CE1 1 
ATOM   228  N  NE2 . HIS A 1 35  ? -5.698  -14.584 1.592   0.50 79.02  ? 298  HIS A NE2 1 
ATOM   229  N  N   . PRO A 1 36  ? -5.668  -19.555 3.305   0.50 82.21  ? 299  PRO A N   1 
ATOM   230  C  CA  . PRO A 1 36  ? -4.573  -20.212 2.588   0.50 79.85  ? 299  PRO A CA  1 
ATOM   231  C  C   . PRO A 1 36  ? -4.361  -19.803 1.120   0.50 79.56  ? 299  PRO A C   1 
ATOM   232  O  O   . PRO A 1 36  ? -3.379  -20.228 0.542   0.50 78.12  ? 299  PRO A O   1 
ATOM   233  C  CB  . PRO A 1 36  ? -4.986  -21.693 2.637   0.50 79.76  ? 299  PRO A CB  1 
ATOM   234  C  CG  . PRO A 1 36  ? -6.498  -21.662 2.679   0.50 79.99  ? 299  PRO A CG  1 
ATOM   235  C  CD  . PRO A 1 36  ? -6.835  -20.431 3.492   0.50 81.09  ? 299  PRO A CD  1 
ATOM   236  N  N   . TYR A 1 37  ? -5.263  -19.000 0.549   0.50 77.64  ? 300  TYR A N   1 
ATOM   237  C  CA  . TYR A 1 37  ? -5.321  -18.711 -0.909  0.50 75.77  ? 300  TYR A CA  1 
ATOM   238  C  C   . TYR A 1 37  ? -4.187  -17.757 -1.293  0.50 76.05  ? 300  TYR A C   1 
ATOM   239  O  O   . TYR A 1 37  ? -3.994  -16.736 -0.604  0.50 79.59  ? 300  TYR A O   1 
ATOM   240  C  CB  . TYR A 1 37  ? -6.706  -18.178 -1.288  0.50 73.27  ? 300  TYR A CB  1 
ATOM   241  C  CG  . TYR A 1 37  ? -7.823  -19.049 -0.776  0.50 68.20  ? 300  TYR A CG  1 
ATOM   242  C  CD1 . TYR A 1 37  ? -8.025  -20.317 -1.292  0.50 68.42  ? 300  TYR A CD1 1 
ATOM   243  C  CD2 . TYR A 1 37  ? -8.638  -18.637 0.263   0.50 66.70  ? 300  TYR A CD2 1 
ATOM   244  C  CE1 . TYR A 1 37  ? -9.021  -21.146 -0.805  0.50 65.65  ? 300  TYR A CE1 1 
ATOM   245  C  CE2 . TYR A 1 37  ? -9.639  -19.452 0.761   0.50 63.94  ? 300  TYR A CE2 1 
ATOM   246  C  CZ  . TYR A 1 37  ? -9.833  -20.709 0.223   0.50 62.32  ? 300  TYR A CZ  1 
ATOM   247  O  OH  . TYR A 1 37  ? -10.814 -21.521 0.705   0.50 65.32  ? 300  TYR A OH  1 
ATOM   248  N  N   . LYS A 1 38  ? -3.460  -18.100 -2.361  0.50 76.13  ? 301  LYS A N   1 
ATOM   249  C  CA  . LYS A 1 38  ? -2.404  -17.249 -2.974  0.50 76.51  ? 301  LYS A CA  1 
ATOM   250  C  C   . LYS A 1 38  ? -2.885  -16.734 -4.336  0.50 74.93  ? 301  LYS A C   1 
ATOM   251  O  O   . LYS A 1 38  ? -2.850  -15.506 -4.545  0.50 74.38  ? 301  LYS A O   1 
ATOM   252  C  CB  . LYS A 1 38  ? -1.091  -18.024 -3.127  0.50 78.79  ? 301  LYS A CB  1 
ATOM   253  C  CG  . LYS A 1 38  ? 0.121   -17.155 -3.441  0.50 82.04  ? 301  LYS A CG  1 
ATOM   254  C  CD  . LYS A 1 38  ? 0.202   -15.909 -2.579  0.50 83.43  ? 301  LYS A CD  1 
ATOM   255  C  CE  . LYS A 1 38  ? 1.111   -14.840 -3.148  0.50 88.12  ? 301  LYS A CE  1 
ATOM   256  N  NZ  . LYS A 1 38  ? 2.530   -15.060 -2.776  0.50 90.85  ? 301  LYS A NZ  1 
ATOM   257  N  N   . THR A 1 39  ? -3.325  -17.640 -5.218  0.50 70.45  ? 302  THR A N   1 
ATOM   258  C  CA  . THR A 1 39  ? -3.672  -17.346 -6.636  0.50 66.25  ? 302  THR A CA  1 
ATOM   259  C  C   . THR A 1 39  ? -5.166  -17.027 -6.767  0.50 62.66  ? 302  THR A C   1 
ATOM   260  O  O   . THR A 1 39  ? -5.548  -16.409 -7.779  0.50 58.59  ? 302  THR A O   1 
ATOM   261  C  CB  . THR A 1 39  ? -3.308  -18.529 -7.537  0.50 64.86  ? 302  THR A CB  1 
ATOM   262  O  OG1 . THR A 1 39  ? -4.396  -19.449 -7.459  0.50 63.74  ? 302  THR A OG1 1 
ATOM   263  C  CG2 . THR A 1 39  ? -2.012  -19.194 -7.131  0.50 65.59  ? 302  THR A CG2 1 
ATOM   264  N  N   . TRP A 1 40  ? -5.970  -17.472 -5.797  0.50 58.77  ? 303  TRP A N   1 
ATOM   265  C  CA  . TRP A 1 40  ? -7.427  -17.200 -5.699  0.50 55.82  ? 303  TRP A CA  1 
ATOM   266  C  C   . TRP A 1 40  ? -7.654  -16.003 -4.774  0.50 57.82  ? 303  TRP A C   1 
ATOM   267  O  O   . TRP A 1 40  ? -7.449  -16.168 -3.551  0.50 53.34  ? 303  TRP A O   1 
ATOM   268  C  CB  . TRP A 1 40  ? -8.167  -18.438 -5.185  0.50 54.94  ? 303  TRP A CB  1 
ATOM   269  C  CG  . TRP A 1 40  ? -8.381  -19.480 -6.233  0.50 52.28  ? 303  TRP A CG  1 
ATOM   270  C  CD1 . TRP A 1 40  ? -7.435  -20.264 -6.822  0.50 52.96  ? 303  TRP A CD1 1 
ATOM   271  C  CD2 . TRP A 1 40  ? -9.633  -19.843 -6.832  0.50 53.45  ? 303  TRP A CD2 1 
ATOM   272  N  NE1 . TRP A 1 40  ? -8.014  -21.090 -7.744  0.50 53.09  ? 303  TRP A NE1 1 
ATOM   273  C  CE2 . TRP A 1 40  ? -9.362  -20.858 -7.772  0.50 51.71  ? 303  TRP A CE2 1 
ATOM   274  C  CE3 . TRP A 1 40  ? -10.952 -19.413 -6.662  0.50 51.36  ? 303  TRP A CE3 1 
ATOM   275  C  CZ2 . TRP A 1 40  ? -10.364 -21.448 -8.539  0.50 51.97  ? 303  TRP A CZ2 1 
ATOM   276  C  CZ3 . TRP A 1 40  ? -11.941 -19.999 -7.419  0.50 53.26  ? 303  TRP A CZ3 1 
ATOM   277  C  CH2 . TRP A 1 40  ? -11.650 -21.002 -8.344  0.50 51.93  ? 303  TRP A CH2 1 
ATOM   278  N  N   . ALA A 1 41  ? -8.206  -14.915 -5.319  0.50 57.84  ? 304  ALA A N   1 
ATOM   279  C  CA  . ALA A 1 41  ? -8.563  -13.742 -4.490  0.50 59.30  ? 304  ALA A CA  1 
ATOM   280  C  C   . ALA A 1 41  ? -9.575  -14.155 -3.420  0.50 60.82  ? 304  ALA A C   1 
ATOM   281  O  O   . ALA A 1 41  ? -10.601 -14.755 -3.777  0.50 56.56  ? 304  ALA A O   1 
ATOM   282  C  CB  . ALA A 1 41  ? -9.129  -12.650 -5.360  0.50 57.95  ? 304  ALA A CB  1 
ATOM   283  N  N   . TYR A 1 42  ? -9.289  -13.831 -2.157  0.50 63.76  ? 305  TYR A N   1 
ATOM   284  C  CA  . TYR A 1 42  ? -10.208 -14.160 -1.037  0.50 64.05  ? 305  TYR A CA  1 
ATOM   285  C  C   . TYR A 1 42  ? -11.062 -12.928 -0.746  0.50 62.75  ? 305  TYR A C   1 
ATOM   286  O  O   . TYR A 1 42  ? -10.561 -11.801 -0.903  0.50 66.21  ? 305  TYR A O   1 
ATOM   287  C  CB  . TYR A 1 42  ? -9.399  -14.607 0.182   0.50 63.85  ? 305  TYR A CB  1 
ATOM   288  C  CG  . TYR A 1 42  ? -10.144 -14.654 1.490   0.50 63.34  ? 305  TYR A CG  1 
ATOM   289  C  CD1 . TYR A 1 42  ? -10.933 -15.740 1.828   0.50 61.89  ? 305  TYR A CD1 1 
ATOM   290  C  CD2 . TYR A 1 42  ? -10.031 -13.624 2.408   0.50 62.31  ? 305  TYR A CD2 1 
ATOM   291  C  CE1 . TYR A 1 42  ? -11.606 -15.794 3.036   0.50 61.51  ? 305  TYR A CE1 1 
ATOM   292  C  CE2 . TYR A 1 42  ? -10.696 -13.663 3.621   0.50 61.01  ? 305  TYR A CE2 1 
ATOM   293  C  CZ  . TYR A 1 42  ? -11.488 -14.751 3.936   0.50 61.36  ? 305  TYR A CZ  1 
ATOM   294  O  OH  . TYR A 1 42  ? -12.147 -14.789 5.129   0.50 64.44  ? 305  TYR A OH  1 
ATOM   295  N  N   . HIS A 1 43  ? -12.316 -13.138 -0.356  0.50 58.98  ? 306  HIS A N   1 
ATOM   296  C  CA  . HIS A 1 43  ? -13.228 -11.988 -0.140  0.50 59.40  ? 306  HIS A CA  1 
ATOM   297  C  C   . HIS A 1 43  ? -13.719 -11.978 1.310   0.50 57.20  ? 306  HIS A C   1 
ATOM   298  O  O   . HIS A 1 43  ? -13.688 -10.903 1.929   0.50 61.26  ? 306  HIS A O   1 
ATOM   299  C  CB  . HIS A 1 43  ? -14.369 -12.025 -1.164  0.50 57.74  ? 306  HIS A CB  1 
ATOM   300  C  CG  . HIS A 1 43  ? -13.917 -11.806 -2.567  0.50 55.17  ? 306  HIS A CG  1 
ATOM   301  N  ND1 . HIS A 1 43  ? -13.676 -10.546 -3.073  0.50 54.65  ? 306  HIS A ND1 1 
ATOM   302  C  CD2 . HIS A 1 43  ? -13.662 -12.673 -3.569  0.50 54.20  ? 306  HIS A CD2 1 
ATOM   303  C  CE1 . HIS A 1 43  ? -13.291 -10.645 -4.328  0.50 53.17  ? 306  HIS A CE1 1 
ATOM   304  N  NE2 . HIS A 1 43  ? -13.275 -11.939 -4.656  0.50 52.74  ? 306  HIS A NE2 1 
ATOM   305  N  N   . GLY A 1 44  ? -14.155 -13.128 1.820   0.50 57.37  ? 307  GLY A N   1 
ATOM   306  C  CA  . GLY A 1 44  ? -14.697 -13.188 3.189   0.50 58.16  ? 307  GLY A CA  1 
ATOM   307  C  C   . GLY A 1 44  ? -15.049 -14.603 3.596   0.50 58.85  ? 307  GLY A C   1 
ATOM   308  O  O   . GLY A 1 44  ? -14.875 -15.515 2.771   0.50 57.25  ? 307  GLY A O   1 
ATOM   309  N  N   . SER A 1 45  ? -15.533 -14.777 4.829   0.50 62.80  ? 308  SER A N   1 
ATOM   310  C  CA  . SER A 1 45  ? -15.859 -16.132 5.336   0.50 62.38  ? 308  SER A CA  1 
ATOM   311  C  C   . SER A 1 45  ? -17.160 -16.105 6.139   0.50 64.39  ? 308  SER A C   1 
ATOM   312  O  O   . SER A 1 45  ? -17.605 -14.999 6.486   0.50 70.58  ? 308  SER A O   1 
ATOM   313  C  CB  . SER A 1 45  ? -14.725 -16.687 6.152   0.50 64.11  ? 308  SER A CB  1 
ATOM   314  O  OG  . SER A 1 45  ? -13.547 -16.797 5.369   0.50 60.60  ? 308  SER A OG  1 
ATOM   315  N  N   . TYR A 1 46  ? -17.733 -17.277 6.415   0.50 64.79  ? 309  TYR A N   1 
ATOM   316  C  CA  . TYR A 1 46  ? -19.006 -17.404 7.178   0.50 65.80  ? 309  TYR A CA  1 
ATOM   317  C  C   . TYR A 1 46  ? -19.201 -18.868 7.612   0.50 67.79  ? 309  TYR A C   1 
ATOM   318  O  O   . TYR A 1 46  ? -18.538 -19.765 7.051   0.50 67.52  ? 309  TYR A O   1 
ATOM   319  C  CB  . TYR A 1 46  ? -20.174 -16.836 6.360   0.50 65.78  ? 309  TYR A CB  1 
ATOM   320  C  CG  . TYR A 1 46  ? -20.762 -17.750 5.310   0.50 65.44  ? 309  TYR A CG  1 
ATOM   321  C  CD1 . TYR A 1 46  ? -21.588 -18.804 5.664   0.50 64.54  ? 309  TYR A CD1 1 
ATOM   322  C  CD2 . TYR A 1 46  ? -20.537 -17.534 3.959   0.50 64.36  ? 309  TYR A CD2 1 
ATOM   323  C  CE1 . TYR A 1 46  ? -22.145 -19.640 4.709   0.50 66.87  ? 309  TYR A CE1 1 
ATOM   324  C  CE2 . TYR A 1 46  ? -21.089 -18.360 2.990   0.50 63.79  ? 309  TYR A CE2 1 
ATOM   325  C  CZ  . TYR A 1 46  ? -21.897 -19.419 3.366   0.50 65.24  ? 309  TYR A CZ  1 
ATOM   326  O  OH  . TYR A 1 46  ? -22.450 -20.246 2.431   0.50 61.38  ? 309  TYR A OH  1 
ATOM   327  N  N   . GLU A 1 47  ? -20.087 -19.095 8.589   0.50 68.71  ? 310  GLU A N   1 
ATOM   328  C  CA  . GLU A 1 47  ? -20.229 -20.368 9.352   0.50 71.66  ? 310  GLU A CA  1 
ATOM   329  C  C   . GLU A 1 47  ? -21.188 -21.326 8.634   0.50 72.34  ? 310  GLU A C   1 
ATOM   330  O  O   . GLU A 1 47  ? -22.305 -20.895 8.287   0.50 75.97  ? 310  GLU A O   1 
ATOM   331  C  CB  . GLU A 1 47  ? -20.722 -20.053 10.769  0.50 76.52  ? 310  GLU A CB  1 
ATOM   332  C  CG  . GLU A 1 47  ? -20.997 -21.278 11.630  0.50 77.11  ? 310  GLU A CG  1 
ATOM   333  C  CD  . GLU A 1 47  ? -21.301 -20.967 13.088  0.50 78.70  ? 310  GLU A CD  1 
ATOM   334  O  OE1 . GLU A 1 47  ? -22.395 -21.349 13.559  0.50 79.24  ? 310  GLU A OE1 1 
ATOM   335  O  OE2 . GLU A 1 47  ? -20.444 -20.340 13.753  0.50 75.58  ? 310  GLU A OE2 1 
ATOM   336  N  N   . THR A 1 48  ? -20.762 -22.580 8.437   0.50 73.96  ? 311  THR A N   1 
ATOM   337  C  CA  . THR A 1 48  ? -21.575 -23.705 7.894   0.50 74.63  ? 311  THR A CA  1 
ATOM   338  C  C   . THR A 1 48  ? -21.247 -24.969 8.695   0.50 78.60  ? 311  THR A C   1 
ATOM   339  O  O   . THR A 1 48  ? -20.562 -24.836 9.728   0.50 79.74  ? 311  THR A O   1 
ATOM   340  C  CB  . THR A 1 48  ? -21.326 -23.920 6.395   0.50 74.64  ? 311  THR A CB  1 
ATOM   341  O  OG1 . THR A 1 48  ? -19.919 -24.048 6.187   0.50 75.89  ? 311  THR A OG1 1 
ATOM   342  C  CG2 . THR A 1 48  ? -21.859 -22.796 5.534   0.50 74.63  ? 311  THR A CG2 1 
ATOM   343  N  N   . LYS A 1 49  ? -21.705 -26.139 8.237   0.50 85.23  ? 312  LYS A N   1 
ATOM   344  C  CA  . LYS A 1 49  ? -21.465 -27.446 8.910   0.50 91.07  ? 312  LYS A CA  1 
ATOM   345  C  C   . LYS A 1 49  ? -21.752 -28.589 7.928   0.50 95.84  ? 312  LYS A C   1 
ATOM   346  O  O   . LYS A 1 49  ? -21.072 -29.631 8.051   0.50 97.60  ? 312  LYS A O   1 
ATOM   347  C  CB  . LYS A 1 49  ? -22.334 -27.562 10.168  0.50 94.15  ? 312  LYS A CB  1 
ATOM   348  C  CG  . LYS A 1 49  ? -21.910 -28.639 11.161  0.50 97.69  ? 312  LYS A CG  1 
ATOM   349  C  CD  . LYS A 1 49  ? -22.487 -28.448 12.553  0.50 97.25  ? 312  LYS A CD  1 
ATOM   350  C  CE  . LYS A 1 49  ? -22.053 -27.147 13.198  0.50 99.47  ? 312  LYS A CE  1 
ATOM   351  N  NZ  . LYS A 1 49  ? -22.788 -26.883 14.458  0.50 100.07 ? 312  LYS A NZ  1 
ATOM   352  N  N   . ALA A 1 54  ? -19.708 -38.289 1.363   0.50 90.99  ? 317  ALA A N   1 
ATOM   353  C  CA  . ALA A 1 54  ? -20.188 -38.994 0.150   0.50 90.92  ? 317  ALA A CA  1 
ATOM   354  C  C   . ALA A 1 54  ? -19.153 -40.042 -0.285  0.50 87.90  ? 317  ALA A C   1 
ATOM   355  O  O   . ALA A 1 54  ? -18.354 -39.745 -1.197  0.50 87.75  ? 317  ALA A O   1 
ATOM   356  C  CB  . ALA A 1 54  ? -20.463 -37.993 -0.948  0.50 88.43  ? 317  ALA A CB  1 
ATOM   357  N  N   . SER A 1 55  ? -19.181 -41.226 0.341   0.50 83.52  ? 318  SER A N   1 
ATOM   358  C  CA  . SER A 1 55  ? -18.230 -42.347 0.109   0.50 75.06  ? 318  SER A CA  1 
ATOM   359  C  C   . SER A 1 55  ? -18.805 -43.342 -0.910  0.50 66.25  ? 318  SER A C   1 
ATOM   360  O  O   . SER A 1 55  ? -20.026 -43.313 -1.166  0.50 63.48  ? 318  SER A O   1 
ATOM   361  C  CB  . SER A 1 55  ? -17.876 -43.042 1.404   0.50 74.04  ? 318  SER A CB  1 
ATOM   362  O  OG  . SER A 1 55  ? -18.963 -43.826 1.878   0.50 72.36  ? 318  SER A OG  1 
ATOM   363  N  N   . SER A 1 56  ? -17.938 -44.197 -1.456  0.50 60.33  ? 319  SER A N   1 
ATOM   364  C  CA  . SER A 1 56  ? -18.273 -45.263 -2.434  0.50 58.36  ? 319  SER A CA  1 
ATOM   365  C  C   . SER A 1 56  ? -18.783 -46.506 -1.694  0.50 54.46  ? 319  SER A C   1 
ATOM   366  O  O   . SER A 1 56  ? -18.008 -47.081 -0.899  0.50 53.47  ? 319  SER A O   1 
ATOM   367  C  CB  . SER A 1 56  ? -17.076 -45.588 -3.291  0.50 62.79  ? 319  SER A CB  1 
ATOM   368  O  OG  . SER A 1 56  ? -15.914 -45.767 -2.494  0.50 59.68  ? 319  SER A OG  1 
ATOM   369  N  N   . MET A 1 57  ? -20.016 -46.935 -1.983  1.00 47.64  ? 320  MET A N   1 
ATOM   370  C  CA  . MET A 1 57  ? -20.623 -48.120 -1.328  1.00 39.11  ? 320  MET A CA  1 
ATOM   371  C  C   . MET A 1 57  ? -20.411 -49.347 -2.226  1.00 31.23  ? 320  MET A C   1 
ATOM   372  O  O   . MET A 1 57  ? -20.289 -49.175 -3.445  1.00 31.53  ? 320  MET A O   1 
ATOM   373  C  CB  . MET A 1 57  ? -22.095 -47.804 -1.153  1.00 40.97  ? 320  MET A CB  1 
ATOM   374  C  CG  . MET A 1 57  ? -22.291 -46.348 -0.671  1.00 43.20  ? 320  MET A CG  1 
ATOM   375  S  SD  . MET A 1 57  ? -21.623 -46.172 1.004   1.00 49.30  ? 320  MET A SD  1 
ATOM   376  C  CE  . MET A 1 57  ? -22.860 -47.126 1.882   1.00 43.85  ? 320  MET A CE  1 
ATOM   377  N  N   . VAL A 1 58  ? -20.370 -50.541 -1.658  1.00 26.36  ? 321  VAL A N   1 
ATOM   378  C  CA  . VAL A 1 58  ? -20.220 -51.769 -2.462  1.00 25.63  ? 321  VAL A CA  1 
ATOM   379  C  C   . VAL A 1 58  ? -21.571 -52.261 -2.997  1.00 27.12  ? 321  VAL A C   1 
ATOM   380  O  O   . VAL A 1 58  ? -22.507 -52.252 -2.234  1.00 28.82  ? 321  VAL A O   1 
ATOM   381  C  CB  . VAL A 1 58  ? -19.460 -52.847 -1.703  1.00 29.54  ? 321  VAL A CB  1 
ATOM   382  C  CG1 . VAL A 1 58  ? -19.377 -54.128 -2.539  1.00 27.77  ? 321  VAL A CG1 1 
ATOM   383  C  CG2 . VAL A 1 58  ? -18.086 -52.315 -1.368  1.00 34.66  ? 321  VAL A CG2 1 
ATOM   384  N  N   . ASN A 1 59  ? -21.616 -52.650 -4.284  1.00 22.99  ? 322  ASN A N   1 
ATOM   385  C  CA  . ASN A 1 59  ? -22.720 -53.402 -4.903  1.00 24.18  ? 322  ASN A CA  1 
ATOM   386  C  C   . ASN A 1 59  ? -22.606 -54.897 -4.545  1.00 24.44  ? 322  ASN A C   1 
ATOM   387  O  O   . ASN A 1 59  ? -21.794 -55.598 -5.179  1.00 24.98  ? 322  ASN A O   1 
ATOM   388  C  CB  . ASN A 1 59  ? -22.724 -53.183 -6.408  1.00 24.06  ? 322  ASN A CB  1 
ATOM   389  C  CG  . ASN A 1 59  ? -23.941 -53.772 -7.087  1.00 25.69  ? 322  ASN A CG  1 
ATOM   390  O  OD1 . ASN A 1 59  ? -24.368 -54.889 -6.783  1.00 24.75  ? 322  ASN A OD1 1 
ATOM   391  N  ND2 . ASN A 1 59  ? -24.491 -53.027 -8.044  1.00 30.03  ? 322  ASN A ND2 1 
ATOM   392  N  N   . GLY A 1 60  ? -23.460 -55.375 -3.643  1.00 23.15  ? 323  GLY A N   1 
ATOM   393  C  CA  . GLY A 1 60  ? -23.456 -56.774 -3.153  1.00 22.62  ? 323  GLY A CA  1 
ATOM   394  C  C   . GLY A 1 60  ? -23.820 -57.809 -4.192  1.00 24.05  ? 323  GLY A C   1 
ATOM   395  O  O   . GLY A 1 60  ? -23.285 -58.943 -4.185  1.00 26.68  ? 323  GLY A O   1 
ATOM   396  N  N   . VAL A 1 61  ? -24.695 -57.471 -5.133  1.00 24.38  ? 324  VAL A N   1 
ATOM   397  C  CA  . VAL A 1 61  ? -25.030 -58.403 -6.214  1.00 24.32  ? 324  VAL A CA  1 
ATOM   398  C  C   . VAL A 1 61  ? -23.767 -58.667 -7.046  1.00 22.52  ? 324  VAL A C   1 
ATOM   399  O  O   . VAL A 1 61  ? -23.434 -59.859 -7.293  1.00 22.52  ? 324  VAL A O   1 
ATOM   400  C  CB  . VAL A 1 61  ? -26.230 -57.863 -7.034  1.00 23.37  ? 324  VAL A CB  1 
ATOM   401  C  CG1 . VAL A 1 61  ? -26.395 -58.628 -8.295  1.00 23.63  ? 324  VAL A CG1 1 
ATOM   402  C  CG2 . VAL A 1 61  ? -27.514 -57.850 -6.184  1.00 25.05  ? 324  VAL A CG2 1 
ATOM   403  N  N   . VAL A 1 62  ? -23.049 -57.636 -7.488  1.00 19.88  ? 325  VAL A N   1 
ATOM   404  C  CA  . VAL A 1 62  ? -21.832 -57.852 -8.338  1.00 20.84  ? 325  VAL A CA  1 
ATOM   405  C  C   . VAL A 1 62  ? -20.739 -58.543 -7.477  1.00 20.06  ? 325  VAL A C   1 
ATOM   406  O  O   . VAL A 1 62  ? -20.144 -59.516 -7.930  1.00 22.64  ? 325  VAL A O   1 
ATOM   407  C  CB  . VAL A 1 62  ? -21.335 -56.552 -9.005  1.00 21.48  ? 325  VAL A CB  1 
ATOM   408  C  CG1 . VAL A 1 62  ? -20.048 -56.753 -9.762  1.00 20.23  ? 325  VAL A CG1 1 
ATOM   409  C  CG2 . VAL A 1 62  ? -22.364 -55.905 -9.924  1.00 22.87  ? 325  VAL A CG2 1 
ATOM   410  N  N   . ARG A 1 63  ? -20.538 -58.143 -6.227  1.00 21.81  ? 326  ARG A N   1 
ATOM   411  C  CA  . ARG A 1 63  ? -19.451 -58.726 -5.424  1.00 23.71  ? 326  ARG A CA  1 
ATOM   412  C  C   . ARG A 1 63  ? -19.746 -60.211 -5.184  1.00 23.22  ? 326  ARG A C   1 
ATOM   413  O  O   . ARG A 1 63  ? -18.777 -61.034 -5.266  1.00 21.96  ? 326  ARG A O   1 
ATOM   414  C  CB  . ARG A 1 63  ? -19.217 -58.008 -4.118  1.00 22.71  ? 326  ARG A CB  1 
ATOM   415  C  CG  . ARG A 1 63  ? -18.108 -58.642 -3.287  1.00 22.32  ? 326  ARG A CG  1 
ATOM   416  C  CD  . ARG A 1 63  ? -17.422 -57.683 -2.338  1.00 21.93  ? 326  ARG A CD  1 
ATOM   417  N  NE  . ARG A 1 63  ? -18.323 -57.232 -1.304  1.00 23.50  ? 326  ARG A NE  1 
ATOM   418  C  CZ  . ARG A 1 63  ? -18.007 -56.425 -0.308  1.00 22.60  ? 326  ARG A CZ  1 
ATOM   419  N  NH1 . ARG A 1 63  ? -16.762 -56.045 -0.130  1.00 23.39  ? 326  ARG A NH1 1 
ATOM   420  N  NH2 . ARG A 1 63  ? -18.938 -56.027 0.555   1.00 23.77  ? 326  ARG A NH2 1 
ATOM   421  N  N   . LEU A 1 64  ? -20.990 -60.586 -4.877  1.00 21.95  ? 327  LEU A N   1 
ATOM   422  C  CA  . LEU A 1 64  ? -21.284 -62.019 -4.589  1.00 23.61  ? 327  LEU A CA  1 
ATOM   423  C  C   . LEU A 1 64  ? -21.012 -62.850 -5.834  1.00 20.65  ? 327  LEU A C   1 
ATOM   424  O  O   . LEU A 1 64  ? -20.715 -64.057 -5.737  1.00 25.37  ? 327  LEU A O   1 
ATOM   425  C  CB  . LEU A 1 64  ? -22.735 -62.217 -4.104  1.00 22.68  ? 327  LEU A CB  1 
ATOM   426  C  CG  . LEU A 1 64  ? -22.955 -61.906 -2.628  1.00 24.51  ? 327  LEU A CG  1 
ATOM   427  C  CD1 . LEU A 1 64  ? -24.444 -62.036 -2.228  1.00 26.93  ? 327  LEU A CD1 1 
ATOM   428  C  CD2 . LEU A 1 64  ? -22.078 -62.757 -1.723  1.00 27.21  ? 327  LEU A CD2 1 
ATOM   429  N  N   . LEU A 1 65  ? -21.121 -62.272 -7.014  1.00 22.74  ? 328  LEU A N   1 
ATOM   430  C  CA  . LEU A 1 65  ? -20.889 -63.056 -8.275  1.00 21.70  ? 328  LEU A CA  1 
ATOM   431  C  C   . LEU A 1 65  ? -19.476 -62.897 -8.842  1.00 22.47  ? 328  LEU A C   1 
ATOM   432  O  O   . LEU A 1 65  ? -19.241 -63.430 -9.973  1.00 23.19  ? 328  LEU A O   1 
ATOM   433  C  CB  . LEU A 1 65  ? -21.972 -62.641 -9.272  1.00 22.24  ? 328  LEU A CB  1 
ATOM   434  C  CG  . LEU A 1 65  ? -23.373 -63.041 -8.781  1.00 22.64  ? 328  LEU A CG  1 
ATOM   435  C  CD1 . LEU A 1 65  ? -24.516 -62.416 -9.611  1.00 22.85  ? 328  LEU A CD1 1 
ATOM   436  C  CD2 . LEU A 1 65  ? -23.497 -64.531 -8.831  1.00 24.29  ? 328  LEU A CD2 1 
ATOM   437  N  N   . THR A 1 66  ? -18.581 -62.225 -8.119  1.00 19.31  ? 329  THR A N   1 
ATOM   438  C  CA  . THR A 1 66  ? -17.173 -62.069 -8.530  1.00 22.30  ? 329  THR A CA  1 
ATOM   439  C  C   . THR A 1 66  ? -16.251 -62.480 -7.354  1.00 21.42  ? 329  THR A C   1 
ATOM   440  O  O   . THR A 1 66  ? -15.248 -61.793 -7.023  1.00 19.95  ? 329  THR A O   1 
ATOM   441  C  CB  . THR A 1 66  ? -16.927 -60.654 -9.083  1.00 21.96  ? 329  THR A CB  1 
ATOM   442  O  OG1 . THR A 1 66  ? -17.330 -59.639 -8.156  1.00 19.58  ? 329  THR A OG1 1 
ATOM   443  C  CG2 . THR A 1 66  ? -17.650 -60.447 -10.399 1.00 22.56  ? 329  THR A CG2 1 
ATOM   444  N  N   . LYS A 1 67  ? -16.506 -63.613 -6.741  1.00 20.35  ? 330  LYS A N   1 
ATOM   445  C  CA  . LYS A 1 67  ? -15.776 -63.992 -5.502  1.00 21.64  ? 330  LYS A CA  1 
ATOM   446  C  C   . LYS A 1 67  ? -14.250 -64.048 -5.722  1.00 20.73  ? 330  LYS A C   1 
ATOM   447  O  O   . LYS A 1 67  ? -13.504 -63.680 -4.816  1.00 22.50  ? 330  LYS A O   1 
ATOM   448  C  CB  . LYS A 1 67  ? -16.348 -65.300 -4.961  1.00 26.34  ? 330  LYS A CB  1 
ATOM   449  C  CG  . LYS A 1 67  ? -15.843 -65.738 -3.602  1.00 25.65  ? 330  LYS A CG  1 
ATOM   450  C  CD  . LYS A 1 67  ? -16.364 -67.093 -3.180  1.00 28.26  ? 330  LYS A CD  1 
ATOM   451  C  CE  . LYS A 1 67  ? -16.207 -67.224 -1.666  1.00 33.26  ? 330  LYS A CE  1 
ATOM   452  N  NZ  . LYS A 1 67  ? -16.345 -68.622 -1.241  1.00 34.65  ? 330  LYS A NZ  1 
ATOM   453  N  N   . PRO A 1 68  ? -13.680 -64.546 -6.820  1.00 19.03  ? 331  PRO A N   1 
ATOM   454  C  CA  . PRO A 1 68  ? -12.219 -64.694 -6.917  1.00 21.10  ? 331  PRO A CA  1 
ATOM   455  C  C   . PRO A 1 68  ? -11.486 -63.349 -6.712  1.00 25.17  ? 331  PRO A C   1 
ATOM   456  O  O   . PRO A 1 68  ? -10.372 -63.333 -6.260  1.00 23.92  ? 331  PRO A O   1 
ATOM   457  C  CB  . PRO A 1 68  ? -12.002 -65.130 -8.363  1.00 22.60  ? 331  PRO A CB  1 
ATOM   458  C  CG  . PRO A 1 68  ? -13.249 -65.930 -8.662  1.00 24.87  ? 331  PRO A CG  1 
ATOM   459  C  CD  . PRO A 1 68  ? -14.383 -65.217 -7.935  1.00 22.85  ? 331  PRO A CD  1 
ATOM   460  N  N   . TRP A 1 69  ? -12.180 -62.231 -6.988  1.00 20.41  ? 332  TRP A N   1 
ATOM   461  C  CA  . TRP A 1 69  ? -11.596 -60.866 -6.922  1.00 23.42  ? 332  TRP A CA  1 
ATOM   462  C  C   . TRP A 1 69  ? -11.661 -60.353 -5.500  1.00 23.17  ? 332  TRP A C   1 
ATOM   463  O  O   . TRP A 1 69  ? -11.084 -59.268 -5.272  1.00 24.02  ? 332  TRP A O   1 
ATOM   464  C  CB  . TRP A 1 69  ? -12.291 -59.950 -7.941  1.00 22.02  ? 332  TRP A CB  1 
ATOM   465  C  CG  . TRP A 1 69  ? -11.972 -60.342 -9.349  1.00 22.01  ? 332  TRP A CG  1 
ATOM   466  C  CD1 . TRP A 1 69  ? -10.852 -59.926 -10.006 1.00 22.83  ? 332  TRP A CD1 1 
ATOM   467  C  CD2 . TRP A 1 69  ? -12.530 -61.408 -10.166 1.00 22.16  ? 332  TRP A CD2 1 
ATOM   468  N  NE1 . TRP A 1 69  ? -10.727 -60.560 -11.212 1.00 22.32  ? 332  TRP A NE1 1 
ATOM   469  C  CE2 . TRP A 1 69  ? -11.754 -61.467 -11.347 1.00 23.63  ? 332  TRP A CE2 1 
ATOM   470  C  CE3 . TRP A 1 69  ? -13.643 -62.239 -10.084 1.00 23.15  ? 332  TRP A CE3 1 
ATOM   471  C  CZ2 . TRP A 1 69  ? -12.054 -62.317 -12.404 1.00 25.36  ? 332  TRP A CZ2 1 
ATOM   472  C  CZ3 . TRP A 1 69  ? -13.950 -63.072 -11.134 1.00 22.54  ? 332  TRP A CZ3 1 
ATOM   473  C  CH2 . TRP A 1 69  ? -13.150 -63.140 -12.271 1.00 23.98  ? 332  TRP A CH2 1 
ATOM   474  N  N   . ASP A 1 70  ? -12.313 -61.075 -4.568  1.00 22.73  ? 333  ASP A N   1 
ATOM   475  C  CA  . ASP A 1 70  ? -12.338 -60.613 -3.152  1.00 20.94  ? 333  ASP A CA  1 
ATOM   476  C  C   . ASP A 1 70  ? -10.922 -60.572 -2.521  1.00 21.71  ? 333  ASP A C   1 
ATOM   477  O  O   . ASP A 1 70  ? -10.769 -59.981 -1.431  1.00 22.81  ? 333  ASP A O   1 
ATOM   478  C  CB  . ASP A 1 70  ? -13.248 -61.488 -2.290  1.00 22.57  ? 333  ASP A CB  1 
ATOM   479  C  CG  . ASP A 1 70  ? -14.737 -61.425 -2.605  1.00 24.09  ? 333  ASP A CG  1 
ATOM   480  O  OD1 . ASP A 1 70  ? -15.125 -60.525 -3.352  1.00 23.47  ? 333  ASP A OD1 1 
ATOM   481  O  OD2 . ASP A 1 70  ? -15.501 -62.262 -2.038  1.00 22.62  ? 333  ASP A OD2 1 
ATOM   482  N  N   . ILE A 1 71  ? -9.947  -61.239 -3.107  1.00 23.19  ? 334  ILE A N   1 
ATOM   483  C  CA  . ILE A 1 71  ? -8.564  -61.361 -2.607  1.00 24.63  ? 334  ILE A CA  1 
ATOM   484  C  C   . ILE A 1 71  ? -7.578  -60.655 -3.546  1.00 28.33  ? 334  ILE A C   1 
ATOM   485  O  O   . ILE A 1 71  ? -6.336  -60.835 -3.330  1.00 29.24  ? 334  ILE A O   1 
ATOM   486  C  CB  . ILE A 1 71  ? -8.197  -62.838 -2.359  1.00 25.07  ? 334  ILE A CB  1 
ATOM   487  C  CG1 . ILE A 1 71  ? -8.228  -63.692 -3.628  1.00 28.56  ? 334  ILE A CG1 1 
ATOM   488  C  CG2 . ILE A 1 71  ? -9.057  -63.452 -1.261  1.00 26.50  ? 334  ILE A CG2 1 
ATOM   489  C  CD1 . ILE A 1 71  ? -7.550  -65.050 -3.462  1.00 34.32  ? 334  ILE A CD1 1 
ATOM   490  N  N   . ILE A 1 72  ? -8.039  -59.836 -4.488  1.00 24.43  ? 335  ILE A N   1 
ATOM   491  C  CA  . ILE A 1 72  ? -7.171  -59.068 -5.420  1.00 24.10  ? 335  ILE A CA  1 
ATOM   492  C  C   . ILE A 1 72  ? -7.196  -57.629 -4.971  1.00 26.70  ? 335  ILE A C   1 
ATOM   493  O  O   . ILE A 1 72  ? -8.188  -56.903 -5.166  1.00 26.82  ? 335  ILE A O   1 
ATOM   494  C  CB  . ILE A 1 72  ? -7.673  -59.221 -6.865  1.00 28.58  ? 335  ILE A CB  1 
ATOM   495  C  CG1 . ILE A 1 72  ? -7.785  -60.702 -7.273  1.00 32.77  ? 335  ILE A CG1 1 
ATOM   496  C  CG2 . ILE A 1 72  ? -6.869  -58.327 -7.821  1.00 26.49  ? 335  ILE A CG2 1 
ATOM   497  C  CD1 . ILE A 1 72  ? -6.738  -61.291 -8.164  1.00 36.40  ? 335  ILE A CD1 1 
ATOM   498  N  N   . PRO A 1 73  ? -6.106  -57.159 -4.330  1.00 29.85  ? 336  PRO A N   1 
ATOM   499  C  CA  . PRO A 1 73  ? -6.041  -55.780 -3.831  1.00 32.47  ? 336  PRO A CA  1 
ATOM   500  C  C   . PRO A 1 73  ? -6.346  -54.683 -4.852  1.00 29.97  ? 336  PRO A C   1 
ATOM   501  O  O   . PRO A 1 73  ? -7.011  -53.711 -4.489  1.00 27.60  ? 336  PRO A O   1 
ATOM   502  C  CB  . PRO A 1 73  ? -4.579  -55.647 -3.370  1.00 35.91  ? 336  PRO A CB  1 
ATOM   503  C  CG  . PRO A 1 73  ? -4.270  -57.067 -2.950  1.00 37.25  ? 336  PRO A CG  1 
ATOM   504  C  CD  . PRO A 1 73  ? -4.904  -57.936 -4.032  1.00 31.68  ? 336  PRO A CD  1 
ATOM   505  N  N   . MET A 1 74  ? -5.954  -54.850 -6.111  1.00 28.53  ? 337  MET A N   1 
ATOM   506  C  CA  . MET A 1 74  ? -6.277  -53.817 -7.126  1.00 31.62  ? 337  MET A CA  1 
ATOM   507  C  C   . MET A 1 74  ? -7.799  -53.622 -7.275  1.00 33.34  ? 337  MET A C   1 
ATOM   508  O  O   . MET A 1 74  ? -8.215  -52.492 -7.526  1.00 29.27  ? 337  MET A O   1 
ATOM   509  C  CB  . MET A 1 74  ? -5.625  -54.126 -8.469  1.00 34.29  ? 337  MET A CB  1 
ATOM   510  C  CG  . MET A 1 74  ? -4.070  -54.068 -8.385  1.00 49.07  ? 337  MET A CG  1 
ATOM   511  S  SD  . MET A 1 74  ? -3.438  -52.303 -8.198  1.00 55.12  ? 337  MET A SD  1 
ATOM   512  C  CE  . MET A 1 74  ? -4.655  -51.380 -9.135  1.00 53.09  ? 337  MET A CE  1 
ATOM   513  N  N   . VAL A 1 75  ? -8.611  -54.643 -7.011  1.00 24.38  ? 338  VAL A N   1 
ATOM   514  C  CA  . VAL A 1 75  ? -10.084 -54.547 -7.064  1.00 22.43  ? 338  VAL A CA  1 
ATOM   515  C  C   . VAL A 1 75  ? -10.589 -54.039 -5.722  1.00 25.29  ? 338  VAL A C   1 
ATOM   516  O  O   . VAL A 1 75  ? -11.336 -53.106 -5.752  1.00 28.76  ? 338  VAL A O   1 
ATOM   517  C  CB  . VAL A 1 75  ? -10.732 -55.918 -7.381  1.00 22.49  ? 338  VAL A CB  1 
ATOM   518  C  CG1 . VAL A 1 75  ? -12.232 -55.920 -7.062  1.00 23.57  ? 338  VAL A CG1 1 
ATOM   519  C  CG2 . VAL A 1 75  ? -10.445 -56.301 -8.827  1.00 23.60  ? 338  VAL A CG2 1 
ATOM   520  N  N   . THR A 1 76  ? -10.194 -54.657 -4.617  1.00 24.96  ? 339  THR A N   1 
ATOM   521  C  CA  . THR A 1 76  ? -10.766 -54.392 -3.273  1.00 25.80  ? 339  THR A CA  1 
ATOM   522  C  C   . THR A 1 76  ? -10.394 -53.015 -2.764  1.00 29.44  ? 339  THR A C   1 
ATOM   523  O  O   . THR A 1 76  ? -11.286 -52.379 -2.171  1.00 27.70  ? 339  THR A O   1 
ATOM   524  C  CB  . THR A 1 76  ? -10.351 -55.437 -2.233  1.00 28.25  ? 339  THR A CB  1 
ATOM   525  O  OG1 . THR A 1 76  ? -8.927  -55.411 -2.057  1.00 29.59  ? 339  THR A OG1 1 
ATOM   526  C  CG2 . THR A 1 76  ? -10.842 -56.812 -2.628  1.00 29.23  ? 339  THR A CG2 1 
ATOM   527  N  N   . GLN A 1 77  ? -9.210  -52.507 -3.104  1.00 29.25  ? 340  GLN A N   1 
ATOM   528  C  CA  . GLN A 1 77  ? -8.801  -51.148 -2.653  1.00 32.94  ? 340  GLN A CA  1 
ATOM   529  C  C   . GLN A 1 77  ? -9.617  -50.064 -3.340  1.00 29.26  ? 340  GLN A C   1 
ATOM   530  O  O   . GLN A 1 77  ? -9.638  -48.981 -2.775  1.00 29.87  ? 340  GLN A O   1 
ATOM   531  C  CB  . GLN A 1 77  ? -7.315  -50.860 -2.867  1.00 33.15  ? 340  GLN A CB  1 
ATOM   532  C  CG  . GLN A 1 77  ? -6.436  -51.948 -2.336  1.00 45.94  ? 340  GLN A CG  1 
ATOM   533  C  CD  . GLN A 1 77  ? -6.042  -51.799 -0.896  1.00 59.53  ? 340  GLN A CD  1 
ATOM   534  O  OE1 . GLN A 1 77  ? -6.588  -50.969 -0.170  1.00 64.83  ? 340  GLN A OE1 1 
ATOM   535  N  NE2 . GLN A 1 77  ? -5.079  -52.623 -0.496  1.00 65.77  ? 340  GLN A NE2 1 
ATOM   536  N  N   . MET A 1 78  ? -10.145 -50.298 -4.544  1.00 27.97  ? 341  MET A N   1 
ATOM   537  C  CA  . MET A 1 78  ? -10.909 -49.269 -5.290  1.00 31.59  ? 341  MET A CA  1 
ATOM   538  C  C   . MET A 1 78  ? -12.124 -48.817 -4.495  1.00 28.51  ? 341  MET A C   1 
ATOM   539  O  O   . MET A 1 78  ? -12.556 -47.689 -4.698  1.00 26.49  ? 341  MET A O   1 
ATOM   540  C  CB  . MET A 1 78  ? -11.398 -49.745 -6.663  1.00 31.80  ? 341  MET A CB  1 
ATOM   541  C  CG  . MET A 1 78  ? -10.284 -49.985 -7.649  1.00 43.90  ? 341  MET A CG  1 
ATOM   542  S  SD  . MET A 1 78  ? -10.884 -50.307 -9.385  1.00 42.31  ? 341  MET A SD  1 
ATOM   543  C  CE  . MET A 1 78  ? -12.199 -49.101 -9.404  1.00 32.74  ? 341  MET A CE  1 
ATOM   544  N  N   . ALA A 1 79  ? -12.702 -49.674 -3.649  1.00 28.30  ? 342  ALA A N   1 
ATOM   545  C  CA  . ALA A 1 79  ? -13.933 -49.351 -2.881  1.00 34.51  ? 342  ALA A CA  1 
ATOM   546  C  C   . ALA A 1 79  ? -13.599 -48.625 -1.571  1.00 34.65  ? 342  ALA A C   1 
ATOM   547  O  O   . ALA A 1 79  ? -14.542 -48.191 -0.913  1.00 32.75  ? 342  ALA A O   1 
ATOM   548  C  CB  . ALA A 1 79  ? -14.709 -50.639 -2.641  1.00 35.27  ? 342  ALA A CB  1 
ATOM   549  N  N   . MET A 1 80  ? -12.330 -48.483 -1.181  1.00 35.76  ? 343  MET A N   1 
ATOM   550  C  CA  . MET A 1 80  ? -11.972 -47.874 0.132   1.00 41.25  ? 343  MET A CA  1 
ATOM   551  C  C   . MET A 1 80  ? -11.798 -46.346 0.010   1.00 52.59  ? 343  MET A C   1 
ATOM   552  O  O   . MET A 1 80  ? -11.509 -45.874 -1.101  1.00 48.45  ? 343  MET A O   1 
ATOM   553  C  CB  . MET A 1 80  ? -10.666 -48.473 0.677   1.00 37.19  ? 343  MET A CB  1 
ATOM   554  C  CG  . MET A 1 80  ? -10.689 -49.990 0.841   1.00 41.09  ? 343  MET A CG  1 
ATOM   555  S  SD  . MET A 1 80  ? -12.131 -50.659 1.829   1.00 45.80  ? 343  MET A SD  1 
ATOM   556  C  CE  . MET A 1 80  ? -11.565 -50.356 3.505   1.00 43.87  ? 343  MET A CE  1 
ATOM   557  N  N   . THR A 1 81  ? -11.903 -45.607 1.130   1.00 74.84  ? 344  THR A N   1 
ATOM   558  C  CA  . THR A 1 81  ? -11.345 -44.236 1.306   1.00 73.92  ? 344  THR A CA  1 
ATOM   559  C  C   . THR A 1 81  ? -12.310 -43.273 1.979   1.00 68.31  ? 344  THR A C   1 
ATOM   560  O  O   . THR A 1 81  ? -13.484 -43.248 1.544   1.00 71.29  ? 344  THR A O   1 
ATOM   561  N  N   . LYS A 1 93  ? -7.752  -29.251 -4.689  0.50 121.79 ? 356  LYS A N   1 
ATOM   562  C  CA  . LYS A 1 93  ? -6.449  -29.688 -4.119  0.50 123.24 ? 356  LYS A CA  1 
ATOM   563  C  C   . LYS A 1 93  ? -5.461  -28.514 -4.159  0.50 124.44 ? 356  LYS A C   1 
ATOM   564  O  O   . LYS A 1 93  ? -5.908  -27.359 -3.988  0.50 124.71 ? 356  LYS A O   1 
ATOM   565  C  CB  . LYS A 1 93  ? -5.910  -30.900 -4.886  0.50 123.90 ? 356  LYS A CB  1 
ATOM   566  C  CG  . LYS A 1 93  ? -5.860  -30.741 -6.400  0.50 125.67 ? 356  LYS A CG  1 
ATOM   567  C  CD  . LYS A 1 93  ? -5.162  -31.882 -7.113  0.50 126.90 ? 356  LYS A CD  1 
ATOM   568  C  CE  . LYS A 1 93  ? -5.062  -31.670 -8.609  0.50 127.77 ? 356  LYS A CE  1 
ATOM   569  N  NZ  . LYS A 1 93  ? -4.265  -32.734 -9.264  0.50 128.29 ? 356  LYS A NZ  1 
ATOM   570  N  N   . GLU A 1 94  ? -4.174  -28.811 -4.371  0.50 124.64 ? 357  GLU A N   1 
ATOM   571  C  CA  . GLU A 1 94  ? -3.067  -27.817 -4.444  0.50 121.31 ? 357  GLU A CA  1 
ATOM   572  C  C   . GLU A 1 94  ? -2.611  -27.670 -5.901  0.50 115.49 ? 357  GLU A C   1 
ATOM   573  O  O   . GLU A 1 94  ? -1.398  -27.479 -6.125  0.50 105.97 ? 357  GLU A O   1 
ATOM   574  C  CB  . GLU A 1 94  ? -1.904  -28.248 -3.549  0.50 125.25 ? 357  GLU A CB  1 
ATOM   575  C  CG  . GLU A 1 94  ? -2.271  -28.324 -2.078  0.50 129.47 ? 357  GLU A CG  1 
ATOM   576  C  CD  . GLU A 1 94  ? -3.483  -29.187 -1.768  0.50 133.23 ? 357  GLU A CD  1 
ATOM   577  O  OE1 . GLU A 1 94  ? -4.030  -29.058 -0.653  0.50 131.81 ? 357  GLU A OE1 1 
ATOM   578  O  OE2 . GLU A 1 94  ? -3.879  -29.987 -2.642  0.50 137.12 ? 357  GLU A OE2 1 
ATOM   579  N  N   . LYS A 1 95  ? -3.554  -27.772 -6.844  0.50 113.42 ? 358  LYS A N   1 
ATOM   580  C  CA  . LYS A 1 95  ? -3.346  -27.504 -8.293  0.50 106.41 ? 358  LYS A CA  1 
ATOM   581  C  C   . LYS A 1 95  ? -4.363  -26.451 -8.748  0.50 98.64  ? 358  LYS A C   1 
ATOM   582  O  O   . LYS A 1 95  ? -4.082  -25.744 -9.736  0.50 89.73  ? 358  LYS A O   1 
ATOM   583  C  CB  . LYS A 1 95  ? -3.479  -28.789 -9.115  0.50 105.66 ? 358  LYS A CB  1 
ATOM   584  C  CG  . LYS A 1 95  ? -3.018  -28.669 -10.561 0.50 102.89 ? 358  LYS A CG  1 
ATOM   585  C  CD  . LYS A 1 95  ? -2.619  -29.989 -11.171 0.50 101.44 ? 358  LYS A CD  1 
ATOM   586  C  CE  . LYS A 1 95  ? -1.624  -29.828 -12.299 0.50 100.87 ? 358  LYS A CE  1 
ATOM   587  N  NZ  . LYS A 1 95  ? -0.963  -31.113 -12.621 0.50 98.90  ? 358  LYS A NZ  1 
ATOM   588  N  N   . VAL A 1 96  ? -5.495  -26.357 -8.043  0.50 95.69  ? 359  VAL A N   1 
ATOM   589  C  CA  . VAL A 1 96  ? -6.530  -25.301 -8.252  0.50 94.29  ? 359  VAL A CA  1 
ATOM   590  C  C   . VAL A 1 96  ? -5.924  -23.951 -7.849  0.50 92.00  ? 359  VAL A C   1 
ATOM   591  O  O   . VAL A 1 96  ? -6.221  -22.949 -8.526  0.50 90.49  ? 359  VAL A O   1 
ATOM   592  C  CB  . VAL A 1 96  ? -7.823  -25.598 -7.465  0.50 93.41  ? 359  VAL A CB  1 
ATOM   593  C  CG1 . VAL A 1 96  ? -7.623  -25.453 -5.963  0.50 93.01  ? 359  VAL A CG1 1 
ATOM   594  C  CG2 . VAL A 1 96  ? -8.978  -24.728 -7.938  0.50 92.03  ? 359  VAL A CG2 1 
ATOM   595  N  N   . ASP A 1 97  ? -5.097  -23.935 -6.798  0.50 89.82  ? 360  ASP A N   1 
ATOM   596  C  CA  . ASP A 1 97  ? -4.438  -22.709 -6.270  0.50 88.97  ? 360  ASP A CA  1 
ATOM   597  C  C   . ASP A 1 97  ? -3.054  -22.564 -6.920  0.50 92.64  ? 360  ASP A C   1 
ATOM   598  O  O   . ASP A 1 97  ? -2.079  -22.309 -6.182  0.50 95.13  ? 360  ASP A O   1 
ATOM   599  C  CB  . ASP A 1 97  ? -4.367  -22.734 -4.738  0.50 85.31  ? 360  ASP A CB  1 
ATOM   600  C  CG  . ASP A 1 97  ? -4.351  -21.357 -4.088  0.50 83.66  ? 360  ASP A CG  1 
ATOM   601  O  OD1 . ASP A 1 97  ? -4.314  -20.352 -4.828  0.50 82.07  ? 360  ASP A OD1 1 
ATOM   602  O  OD2 . ASP A 1 97  ? -4.382  -21.296 -2.842  0.50 83.56  ? 360  ASP A OD2 1 
ATOM   603  N  N   . THR A 1 98  ? -2.977  -22.717 -8.249  0.50 93.25  ? 361  THR A N   1 
ATOM   604  C  CA  . THR A 1 98  ? -1.767  -22.447 -9.076  0.50 94.59  ? 361  THR A CA  1 
ATOM   605  C  C   . THR A 1 98  ? -2.090  -21.330 -10.077 0.50 94.16  ? 361  THR A C   1 
ATOM   606  O  O   . THR A 1 98  ? -3.284  -21.012 -10.236 0.50 91.90  ? 361  THR A O   1 
ATOM   607  C  CB  . THR A 1 98  ? -1.263  -23.716 -9.780  0.50 95.32  ? 361  THR A CB  1 
ATOM   608  O  OG1 . THR A 1 98  ? -2.245  -24.148 -10.723 0.50 95.86  ? 361  THR A OG1 1 
ATOM   609  C  CG2 . THR A 1 98  ? -0.960  -24.841 -8.815  0.50 95.09  ? 361  THR A CG2 1 
ATOM   610  N  N   . ARG A 1 99  ? -1.067  -20.755 -10.717 0.50 96.99  ? 362  ARG A N   1 
ATOM   611  C  CA  . ARG A 1 99  ? -1.221  -19.656 -11.708 0.50 101.68 ? 362  ARG A CA  1 
ATOM   612  C  C   . ARG A 1 99  ? -0.595  -20.085 -13.040 0.50 102.48 ? 362  ARG A C   1 
ATOM   613  O  O   . ARG A 1 99  ? 0.318   -20.937 -13.017 0.50 103.39 ? 362  ARG A O   1 
ATOM   614  C  CB  . ARG A 1 99  ? -0.575  -18.367 -11.190 0.50 106.07 ? 362  ARG A CB  1 
ATOM   615  C  CG  . ARG A 1 99  ? -1.316  -17.100 -11.591 0.50 110.99 ? 362  ARG A CG  1 
ATOM   616  C  CD  . ARG A 1 99  ? -0.404  -15.889 -11.651 0.50 115.19 ? 362  ARG A CD  1 
ATOM   617  N  NE  . ARG A 1 99  ? 0.626   -16.027 -12.673 0.50 118.14 ? 362  ARG A NE  1 
ATOM   618  C  CZ  . ARG A 1 99  ? 1.463   -15.061 -13.034 0.50 113.96 ? 362  ARG A CZ  1 
ATOM   619  N  NH1 . ARG A 1 99  ? 1.393   -13.875 -12.454 0.50 114.58 ? 362  ARG A NH1 1 
ATOM   620  N  NH2 . ARG A 1 99  ? 2.365   -15.283 -13.973 0.50 111.48 ? 362  ARG A NH2 1 
ATOM   621  N  N   . THR A 1 100 ? -1.082  -19.516 -14.150 1.00 100.01 ? 363  THR A N   1 
ATOM   622  C  CA  . THR A 1 100 ? -0.580  -19.791 -15.523 1.00 92.22  ? 363  THR A CA  1 
ATOM   623  C  C   . THR A 1 100 ? -0.088  -18.474 -16.119 1.00 84.33  ? 363  THR A C   1 
ATOM   624  O  O   . THR A 1 100 ? -0.907  -17.553 -16.211 1.00 96.12  ? 363  THR A O   1 
ATOM   625  C  CB  . THR A 1 100 ? -1.682  -20.400 -16.402 1.00 96.57  ? 363  THR A CB  1 
ATOM   626  O  OG1 . THR A 1 100 ? -2.370  -21.417 -15.670 1.00 81.87  ? 363  THR A OG1 1 
ATOM   627  C  CG2 . THR A 1 100 ? -1.149  -20.982 -17.693 1.00 98.95  ? 363  THR A CG2 1 
ATOM   628  N  N   . GLN A 1 101 ? 1.190   -18.384 -16.496 1.00 85.85  ? 364  GLN A N   1 
ATOM   629  C  CA  . GLN A 1 101 ? 1.777   -17.167 -17.124 1.00 84.86  ? 364  GLN A CA  1 
ATOM   630  C  C   . GLN A 1 101 ? 1.003   -16.833 -18.412 1.00 79.13  ? 364  GLN A C   1 
ATOM   631  O  O   . GLN A 1 101 ? 0.452   -17.747 -19.029 1.00 74.21  ? 364  GLN A O   1 
ATOM   632  C  CB  . GLN A 1 101 ? 3.279   -17.346 -17.376 1.00 79.85  ? 364  GLN A CB  1 
ATOM   633  C  CG  . GLN A 1 101 ? 3.887   -16.196 -18.179 1.00 92.34  ? 364  GLN A CG  1 
ATOM   634  C  CD  . GLN A 1 101 ? 5.378   -16.012 -18.010 1.00 98.31  ? 364  GLN A CD  1 
ATOM   635  O  OE1 . GLN A 1 101 ? 6.150   -16.966 -18.088 1.00 107.58 ? 364  GLN A OE1 1 
ATOM   636  N  NE2 . GLN A 1 101 ? 5.800   -14.770 -17.798 1.00 88.64  ? 364  GLN A NE2 1 
ATOM   637  N  N   . GLU A 1 102 ? 0.960   -15.552 -18.787 1.00 78.23  ? 365  GLU A N   1 
ATOM   638  C  CA  . GLU A 1 102 ? 0.391   -15.052 -20.066 1.00 71.80  ? 365  GLU A CA  1 
ATOM   639  C  C   . GLU A 1 102 ? 1.257   -15.542 -21.229 1.00 67.57  ? 365  GLU A C   1 
ATOM   640  O  O   . GLU A 1 102 ? 2.478   -15.386 -21.240 1.00 56.14  ? 365  GLU A O   1 
ATOM   641  C  CB  . GLU A 1 102 ? 0.280   -13.522 -20.025 1.00 85.24  ? 365  GLU A CB  1 
ATOM   642  C  CG  . GLU A 1 102 ? -0.280  -12.878 -21.294 1.00 94.61  ? 365  GLU A CG  1 
ATOM   643  C  CD  . GLU A 1 102 ? -1.723  -12.393 -21.246 1.00 101.40 ? 365  GLU A CD  1 
ATOM   644  O  OE1 . GLU A 1 102 ? -1.977  -11.245 -21.680 1.00 108.26 ? 365  GLU A OE1 1 
ATOM   645  O  OE2 . GLU A 1 102 ? -2.597  -13.169 -20.807 1.00 101.81 ? 365  GLU A OE2 1 
ATOM   646  N  N   . PRO A 1 103 ? 0.648   -16.151 -22.269 1.00 59.12  ? 366  PRO A N   1 
ATOM   647  C  CA  . PRO A 1 103 ? 1.387   -16.523 -23.472 1.00 55.86  ? 366  PRO A CA  1 
ATOM   648  C  C   . PRO A 1 103 ? 2.027   -15.286 -24.116 1.00 55.77  ? 366  PRO A C   1 
ATOM   649  O  O   . PRO A 1 103 ? 1.558   -14.226 -23.825 1.00 49.36  ? 366  PRO A O   1 
ATOM   650  C  CB  . PRO A 1 103 ? 0.309   -17.125 -24.390 1.00 56.68  ? 366  PRO A CB  1 
ATOM   651  C  CG  . PRO A 1 103 ? -0.779  -17.574 -23.435 1.00 61.31  ? 366  PRO A CG  1 
ATOM   652  C  CD  . PRO A 1 103 ? -0.775  -16.521 -22.346 1.00 61.88  ? 366  PRO A CD  1 
ATOM   653  N  N   . LYS A 1 104 ? 3.017   -15.488 -24.992 1.00 54.77  ? 367  LYS A N   1 
ATOM   654  C  CA  . LYS A 1 104 ? 3.714   -14.439 -25.789 1.00 56.96  ? 367  LYS A CA  1 
ATOM   655  C  C   . LYS A 1 104 ? 2.819   -13.982 -26.952 1.00 57.93  ? 367  LYS A C   1 
ATOM   656  O  O   . LYS A 1 104 ? 1.872   -14.678 -27.293 1.00 47.67  ? 367  LYS A O   1 
ATOM   657  C  CB  . LYS A 1 104 ? 5.011   -14.985 -26.412 1.00 66.76  ? 367  LYS A CB  1 
ATOM   658  C  CG  . LYS A 1 104 ? 5.947   -15.780 -25.501 1.00 69.24  ? 367  LYS A CG  1 
ATOM   659  C  CD  . LYS A 1 104 ? 6.792   -14.928 -24.621 1.00 71.32  ? 367  LYS A CD  1 
ATOM   660  C  CE  . LYS A 1 104 ? 7.474   -15.707 -23.522 1.00 71.73  ? 367  LYS A CE  1 
ATOM   661  N  NZ  . LYS A 1 104 ? 7.208   -15.069 -22.209 1.00 67.27  ? 367  LYS A NZ  1 
ATOM   662  N  N   . GLU A 1 105 ? 3.197   -12.909 -27.633 1.00 49.42  ? 368  GLU A N   1 
ATOM   663  C  CA  . GLU A 1 105 ? 2.383   -12.249 -28.678 1.00 59.01  ? 368  GLU A CA  1 
ATOM   664  C  C   . GLU A 1 105 ? 2.229   -13.180 -29.888 1.00 52.12  ? 368  GLU A C   1 
ATOM   665  O  O   . GLU A 1 105 ? 1.102   -13.231 -30.426 1.00 49.00  ? 368  GLU A O   1 
ATOM   666  C  CB  . GLU A 1 105 ? 3.012   -10.895 -29.048 1.00 70.82  ? 368  GLU A CB  1 
ATOM   667  C  CG  . GLU A 1 105 ? 3.047   -9.912  -27.875 1.00 75.70  ? 368  GLU A CG  1 
ATOM   668  C  CD  . GLU A 1 105 ? 1.682   -9.414  -27.421 1.00 80.67  ? 368  GLU A CD  1 
ATOM   669  O  OE1 . GLU A 1 105 ? 0.991   -8.791  -28.256 1.00 93.93  ? 368  GLU A OE1 1 
ATOM   670  O  OE2 . GLU A 1 105 ? 1.302   -9.658  -26.247 1.00 65.60  ? 368  GLU A OE2 1 
ATOM   671  N  N   . GLY A 1 106 ? 3.304   -13.863 -30.311 1.00 41.68  ? 369  GLY A N   1 
ATOM   672  C  CA  . GLY A 1 106 ? 3.258   -14.857 -31.398 1.00 46.81  ? 369  GLY A CA  1 
ATOM   673  C  C   . GLY A 1 106 ? 2.243   -15.968 -31.065 1.00 41.88  ? 369  GLY A C   1 
ATOM   674  O  O   . GLY A 1 106 ? 1.411   -16.285 -31.950 1.00 41.58  ? 369  GLY A O   1 
ATOM   675  N  N   . THR A 1 107 ? 2.284   -16.490 -29.841 1.00 37.88  ? 370  THR A N   1 
ATOM   676  C  CA  . THR A 1 107 ? 1.354   -17.545 -29.342 1.00 46.55  ? 370  THR A CA  1 
ATOM   677  C  C   . THR A 1 107 ? -0.100  -17.062 -29.398 1.00 48.71  ? 370  THR A C   1 
ATOM   678  O  O   . THR A 1 107 ? -0.922  -17.736 -30.016 1.00 45.13  ? 370  THR A O   1 
ATOM   679  C  CB  . THR A 1 107 ? 1.734   -18.030 -27.948 1.00 45.80  ? 370  THR A CB  1 
ATOM   680  O  OG1 . THR A 1 107 ? 3.128   -18.334 -28.039 1.00 45.70  ? 370  THR A OG1 1 
ATOM   681  C  CG2 . THR A 1 107 ? 0.942   -19.255 -27.532 1.00 50.37  ? 370  THR A CG2 1 
ATOM   682  N  N   . LYS A 1 108 ? -0.389  -15.909 -28.781 0.50 47.55  ? 371  LYS A N   1 
ATOM   683  C  CA  . LYS A 1 108 ? -1.730  -15.256 -28.774 0.50 46.49  ? 371  LYS A CA  1 
ATOM   684  C  C   . LYS A 1 108 ? -2.263  -15.093 -30.206 0.50 45.63  ? 371  LYS A C   1 
ATOM   685  O  O   . LYS A 1 108 ? -3.433  -15.448 -30.444 0.50 44.64  ? 371  LYS A O   1 
ATOM   686  C  CB  . LYS A 1 108 ? -1.652  -13.904 -28.063 0.50 49.70  ? 371  LYS A CB  1 
ATOM   687  C  CG  . LYS A 1 108 ? -1.444  -13.995 -26.559 0.50 52.79  ? 371  LYS A CG  1 
ATOM   688  C  CD  . LYS A 1 108 ? -1.905  -12.771 -25.806 0.50 54.59  ? 371  LYS A CD  1 
ATOM   689  C  CE  . LYS A 1 108 ? -0.849  -11.689 -25.746 0.50 57.63  ? 371  LYS A CE  1 
ATOM   690  N  NZ  . LYS A 1 108 ? -0.779  -11.084 -24.394 0.50 58.81  ? 371  LYS A NZ  1 
ATOM   691  N  N   . LYS A 1 109 ? -1.441  -14.587 -31.126 0.50 44.29  ? 372  LYS A N   1 
ATOM   692  C  CA  . LYS A 1 109 ? -1.804  -14.428 -32.558 0.50 47.05  ? 372  LYS A CA  1 
ATOM   693  C  C   . LYS A 1 109 ? -2.181  -15.791 -33.157 0.50 46.59  ? 372  LYS A C   1 
ATOM   694  O  O   . LYS A 1 109 ? -3.220  -15.858 -33.851 0.50 46.74  ? 372  LYS A O   1 
ATOM   695  C  CB  . LYS A 1 109 ? -0.647  -13.785 -33.329 0.50 52.28  ? 372  LYS A CB  1 
ATOM   696  C  CG  . LYS A 1 109 ? -0.992  -13.305 -34.733 0.50 58.72  ? 372  LYS A CG  1 
ATOM   697  C  CD  . LYS A 1 109 ? -2.058  -12.222 -34.770 0.50 63.80  ? 372  LYS A CD  1 
ATOM   698  C  CE  . LYS A 1 109 ? -1.624  -10.939 -34.090 0.50 66.42  ? 372  LYS A CE  1 
ATOM   699  N  NZ  . LYS A 1 109 ? -2.437  -9.782  -34.536 0.50 69.28  ? 372  LYS A NZ  1 
ATOM   700  N  N   . LEU A 1 110 ? -1.355  -16.822 -32.928 1.00 46.62  ? 373  LEU A N   1 
ATOM   701  C  CA  . LEU A 1 110 ? -1.568  -18.199 -33.505 1.00 45.94  ? 373  LEU A CA  1 
ATOM   702  C  C   . LEU A 1 110 ? -2.909  -18.757 -33.004 1.00 32.17  ? 373  LEU A C   1 
ATOM   703  O  O   . LEU A 1 110 ? -3.705  -19.221 -33.818 1.00 34.19  ? 373  LEU A O   1 
ATOM   704  C  CB  . LEU A 1 110 ? -0.427  -19.143 -33.103 1.00 43.25  ? 373  LEU A CB  1 
ATOM   705  C  CG  . LEU A 1 110 ? 0.902   -18.913 -33.827 1.00 42.06  ? 373  LEU A CG  1 
ATOM   706  C  CD1 . LEU A 1 110 ? 2.072   -19.492 -33.032 1.00 40.40  ? 373  LEU A CD1 1 
ATOM   707  C  CD2 . LEU A 1 110 ? 0.830   -19.472 -35.253 1.00 42.58  ? 373  LEU A CD2 1 
ATOM   708  N  N   . MET A 1 111 ? -3.174  -18.586 -31.739 1.00 30.46  ? 374  MET A N   1 
ATOM   709  C  CA  . MET A 1 111 ? -4.449  -19.022 -31.108 1.00 35.42  ? 374  MET A CA  1 
ATOM   710  C  C   . MET A 1 111 ? -5.677  -18.304 -31.696 1.00 39.34  ? 374  MET A C   1 
ATOM   711  O  O   . MET A 1 111 ? -6.698  -18.988 -31.976 1.00 34.63  ? 374  MET A O   1 
ATOM   712  C  CB  . MET A 1 111 ? -4.383  -18.846 -29.588 1.00 32.28  ? 374  MET A CB  1 
ATOM   713  C  CG  . MET A 1 111 ? -3.397  -19.854 -28.942 1.00 34.08  ? 374  MET A CG  1 
ATOM   714  S  SD  . MET A 1 111 ? -3.501  -20.071 -27.171 1.00 44.58  ? 374  MET A SD  1 
ATOM   715  C  CE  . MET A 1 111 ? -3.090  -18.441 -26.561 1.00 40.47  ? 374  MET A CE  1 
ATOM   716  N  N   . LYS A 1 112 ? -5.587  -16.978 -31.869 0.50 39.53  ? 375  LYS A N   1 
ATOM   717  C  CA  . LYS A 1 112 ? -6.703  -16.106 -32.325 0.50 40.70  ? 375  LYS A CA  1 
ATOM   718  C  C   . LYS A 1 112 ? -7.077  -16.497 -33.755 0.50 38.78  ? 375  LYS A C   1 
ATOM   719  O  O   . LYS A 1 112 ? -8.275  -16.706 -34.013 0.50 38.96  ? 375  LYS A O   1 
ATOM   720  C  CB  . LYS A 1 112 ? -6.300  -14.625 -32.279 0.50 47.08  ? 375  LYS A CB  1 
ATOM   721  C  CG  . LYS A 1 112 ? -7.258  -13.703 -31.533 0.50 53.21  ? 375  LYS A CG  1 
ATOM   722  C  CD  . LYS A 1 112 ? -7.029  -13.718 -30.024 0.50 57.71  ? 375  LYS A CD  1 
ATOM   723  C  CE  . LYS A 1 112 ? -8.212  -13.245 -29.202 0.50 58.38  ? 375  LYS A CE  1 
ATOM   724  N  NZ  . LYS A 1 112 ? -8.053  -13.600 -27.769 0.50 55.80  ? 375  LYS A NZ  1 
ATOM   725  N  N   . ILE A 1 113 ? -6.077  -16.596 -34.637 1.00 36.53  ? 376  ILE A N   1 
ATOM   726  C  CA  . ILE A 1 113 ? -6.278  -17.000 -36.058 1.00 35.90  ? 376  ILE A CA  1 
ATOM   727  C  C   . ILE A 1 113 ? -6.856  -18.415 -36.124 1.00 38.86  ? 376  ILE A C   1 
ATOM   728  O  O   . ILE A 1 113 ? -7.784  -18.646 -36.981 1.00 37.22  ? 376  ILE A O   1 
ATOM   729  C  CB  . ILE A 1 113 ? -4.964  -16.949 -36.856 1.00 36.05  ? 376  ILE A CB  1 
ATOM   730  C  CG1 . ILE A 1 113 ? -4.431  -15.523 -37.000 1.00 44.61  ? 376  ILE A CG1 1 
ATOM   731  C  CG2 . ILE A 1 113 ? -5.086  -17.580 -38.223 1.00 37.47  ? 376  ILE A CG2 1 
ATOM   732  C  CD1 . ILE A 1 113 ? -3.029  -15.512 -37.560 1.00 44.09  ? 376  ILE A CD1 1 
ATOM   733  N  N   . THR A 1 114 ? -6.287  -19.354 -35.345 1.00 35.85  ? 377  THR A N   1 
ATOM   734  C  CA  . THR A 1 114 ? -6.751  -20.766 -35.370 1.00 33.92  ? 377  THR A CA  1 
ATOM   735  C  C   . THR A 1 114 ? -8.183  -20.859 -34.853 1.00 28.93  ? 377  THR A C   1 
ATOM   736  O  O   . THR A 1 114 ? -9.030  -21.521 -35.517 1.00 29.61  ? 377  THR A O   1 
ATOM   737  C  CB  . THR A 1 114 ? -5.793  -21.689 -34.624 1.00 33.72  ? 377  THR A CB  1 
ATOM   738  O  OG1 . THR A 1 114 ? -4.539  -21.439 -35.266 1.00 29.78  ? 377  THR A OG1 1 
ATOM   739  C  CG2 . THR A 1 114 ? -6.158  -23.140 -34.817 1.00 32.80  ? 377  THR A CG2 1 
ATOM   740  N  N   . ALA A 1 115 ? -8.456  -20.241 -33.714 1.00 32.99  ? 378  ALA A N   1 
ATOM   741  C  CA  . ALA A 1 115 ? -9.814  -20.216 -33.121 1.00 35.62  ? 378  ALA A CA  1 
ATOM   742  C  C   . ALA A 1 115 ? -10.843 -19.615 -34.099 1.00 37.34  ? 378  ALA A C   1 
ATOM   743  O  O   . ALA A 1 115 ? -11.957 -20.222 -34.308 1.00 35.07  ? 378  ALA A O   1 
ATOM   744  C  CB  . ALA A 1 115 ? -9.807  -19.510 -31.806 1.00 33.82  ? 378  ALA A CB  1 
ATOM   745  N  N   . GLU A 1 116 ? -10.508 -18.478 -34.707 0.50 36.73  ? 379  GLU A N   1 
ATOM   746  C  CA  . GLU A 1 116 ? -11.425 -17.846 -35.690 0.50 39.33  ? 379  GLU A CA  1 
ATOM   747  C  C   . GLU A 1 116 ? -11.725 -18.852 -36.804 0.50 37.23  ? 379  GLU A C   1 
ATOM   748  O  O   . GLU A 1 116 ? -12.906 -19.050 -37.118 0.50 39.37  ? 379  GLU A O   1 
ATOM   749  C  CB  . GLU A 1 116 ? -10.801 -16.561 -36.239 0.50 40.81  ? 379  GLU A CB  1 
ATOM   750  C  CG  . GLU A 1 116 ? -11.662 -15.859 -37.271 0.50 43.78  ? 379  GLU A CG  1 
ATOM   751  C  CD  . GLU A 1 116 ? -11.038 -14.607 -37.864 0.50 44.42  ? 379  GLU A CD  1 
ATOM   752  O  OE1 . GLU A 1 116 ? -9.871  -14.319 -37.538 0.50 45.94  ? 379  GLU A OE1 1 
ATOM   753  O  OE2 . GLU A 1 116 ? -11.722 -13.924 -38.649 0.50 52.43  ? 379  GLU A OE2 1 
ATOM   754  N  N   . TRP A 1 117 ? -10.686 -19.473 -37.357 1.00 34.60  ? 380  TRP A N   1 
ATOM   755  C  CA  . TRP A 1 117 ? -10.865 -20.429 -38.452 1.00 34.06  ? 380  TRP A CA  1 
ATOM   756  C  C   . TRP A 1 117 ? -11.685 -21.647 -37.950 1.00 34.86  ? 380  TRP A C   1 
ATOM   757  O  O   . TRP A 1 117 ? -12.549 -22.143 -38.696 1.00 29.88  ? 380  TRP A O   1 
ATOM   758  C  CB  . TRP A 1 117 ? -9.490  -20.795 -38.972 1.00 34.50  ? 380  TRP A CB  1 
ATOM   759  C  CG  . TRP A 1 117 ? -9.598  -21.853 -39.993 1.00 30.72  ? 380  TRP A CG  1 
ATOM   760  C  CD1 . TRP A 1 117 ? -9.772  -21.669 -41.320 1.00 30.16  ? 380  TRP A CD1 1 
ATOM   761  C  CD2 . TRP A 1 117 ? -9.587  -23.264 -39.766 1.00 36.23  ? 380  TRP A CD2 1 
ATOM   762  N  NE1 . TRP A 1 117 ? -9.786  -22.868 -41.948 1.00 36.24  ? 380  TRP A NE1 1 
ATOM   763  C  CE2 . TRP A 1 117 ? -9.677  -23.871 -41.027 1.00 33.38  ? 380  TRP A CE2 1 
ATOM   764  C  CE3 . TRP A 1 117 ? -9.453  -24.073 -38.641 1.00 35.82  ? 380  TRP A CE3 1 
ATOM   765  C  CZ2 . TRP A 1 117 ? -9.672  -25.252 -41.199 1.00 37.57  ? 380  TRP A CZ2 1 
ATOM   766  C  CZ3 . TRP A 1 117 ? -9.407  -25.435 -38.812 1.00 30.20  ? 380  TRP A CZ3 1 
ATOM   767  C  CH2 . TRP A 1 117 ? -9.551  -26.019 -40.064 1.00 31.89  ? 380  TRP A CH2 1 
ATOM   768  N  N   . LEU A 1 118 ? -11.499 -22.074 -36.707 1.00 33.97  ? 381  LEU A N   1 
ATOM   769  C  CA  . LEU A 1 118 ? -12.125 -23.347 -36.246 1.00 31.98  ? 381  LEU A CA  1 
ATOM   770  C  C   . LEU A 1 118 ? -13.628 -23.142 -35.996 1.00 28.87  ? 381  LEU A C   1 
ATOM   771  O  O   . LEU A 1 118 ? -14.385 -23.988 -36.454 1.00 31.46  ? 381  LEU A O   1 
ATOM   772  C  CB  . LEU A 1 118 ? -11.393 -23.865 -35.009 1.00 30.86  ? 381  LEU A CB  1 
ATOM   773  C  CG  . LEU A 1 118 ? -11.790 -25.279 -34.569 1.00 32.23  ? 381  LEU A CG  1 
ATOM   774  C  CD1 . LEU A 1 118 ? -11.509 -26.303 -35.652 1.00 33.69  ? 381  LEU A CD1 1 
ATOM   775  C  CD2 . LEU A 1 118 ? -11.058 -25.620 -33.286 1.00 34.59  ? 381  LEU A CD2 1 
ATOM   776  N  N   . TRP A 1 119 ? -14.040 -22.026 -35.384 1.00 32.59  ? 382  TRP A N   1 
ATOM   777  C  CA  . TRP A 1 119 ? -15.493 -21.721 -35.179 1.00 36.95  ? 382  TRP A CA  1 
ATOM   778  C  C   . TRP A 1 119 ? -16.202 -21.591 -36.537 1.00 36.56  ? 382  TRP A C   1 
ATOM   779  O  O   . TRP A 1 119 ? -17.296 -22.221 -36.715 1.00 38.13  ? 382  TRP A O   1 
ATOM   780  C  CB  . TRP A 1 119 ? -15.682 -20.491 -34.304 1.00 33.74  ? 382  TRP A CB  1 
ATOM   781  C  CG  . TRP A 1 119 ? -15.439 -20.699 -32.849 1.00 28.84  ? 382  TRP A CG  1 
ATOM   782  C  CD1 . TRP A 1 119 ? -14.637 -19.944 -32.065 1.00 32.66  ? 382  TRP A CD1 1 
ATOM   783  C  CD2 . TRP A 1 119 ? -16.091 -21.622 -31.948 1.00 28.72  ? 382  TRP A CD2 1 
ATOM   784  N  NE1 . TRP A 1 119 ? -14.725 -20.322 -30.758 1.00 28.43  ? 382  TRP A NE1 1 
ATOM   785  C  CE2 . TRP A 1 119 ? -15.579 -21.383 -30.666 1.00 28.40  ? 382  TRP A CE2 1 
ATOM   786  C  CE3 . TRP A 1 119 ? -17.066 -22.603 -32.088 1.00 29.67  ? 382  TRP A CE3 1 
ATOM   787  C  CZ2 . TRP A 1 119 ? -15.949 -22.129 -29.554 1.00 27.15  ? 382  TRP A CZ2 1 
ATOM   788  C  CZ3 . TRP A 1 119 ? -17.425 -23.353 -30.997 1.00 29.10  ? 382  TRP A CZ3 1 
ATOM   789  C  CH2 . TRP A 1 119 ? -16.892 -23.101 -29.744 1.00 26.84  ? 382  TRP A CH2 1 
ATOM   790  N  N   . LYS A 1 120 ? -15.564 -20.978 -37.544 1.00 37.30  ? 383  LYS A N   1 
ATOM   791  C  CA  . LYS A 1 120 ? -16.151 -20.980 -38.911 1.00 36.26  ? 383  LYS A CA  1 
ATOM   792  C  C   . LYS A 1 120 ? -16.300 -22.392 -39.427 1.00 36.95  ? 383  LYS A C   1 
ATOM   793  O  O   . LYS A 1 120 ? -17.401 -22.694 -39.979 1.00 35.20  ? 383  LYS A O   1 
ATOM   794  C  CB  . LYS A 1 120 ? -15.396 -20.152 -39.958 1.00 46.26  ? 383  LYS A CB  1 
ATOM   795  C  CG  . LYS A 1 120 ? -15.441 -18.651 -39.725 1.00 55.75  ? 383  LYS A CG  1 
ATOM   796  C  CD  . LYS A 1 120 ? -14.804 -17.796 -40.814 1.00 65.95  ? 383  LYS A CD  1 
ATOM   797  C  CE  . LYS A 1 120 ? -14.782 -16.327 -40.425 1.00 72.13  ? 383  LYS A CE  1 
ATOM   798  N  NZ  . LYS A 1 120 ? -13.434 -15.722 -40.590 1.00 73.29  ? 383  LYS A NZ  1 
ATOM   799  N  N   . GLU A 1 121 ? -15.286 -23.257 -39.336 1.00 32.46  ? 384  GLU A N   1 
ATOM   800  C  CA  . GLU A 1 121 ? -15.484 -24.612 -39.918 1.00 34.39  ? 384  GLU A CA  1 
ATOM   801  C  C   . GLU A 1 121 ? -16.594 -25.326 -39.172 1.00 33.89  ? 384  GLU A C   1 
ATOM   802  O  O   . GLU A 1 121 ? -17.324 -26.074 -39.830 1.00 36.86  ? 384  GLU A O   1 
ATOM   803  C  CB  . GLU A 1 121 ? -14.279 -25.553 -39.800 1.00 36.10  ? 384  GLU A CB  1 
ATOM   804  C  CG  . GLU A 1 121 ? -13.154 -25.066 -40.622 1.00 41.55  ? 384  GLU A CG  1 
ATOM   805  C  CD  . GLU A 1 121 ? -13.374 -25.199 -42.123 1.00 42.56  ? 384  GLU A CD  1 
ATOM   806  O  OE1 . GLU A 1 121 ? -13.826 -26.282 -42.599 1.00 44.19  ? 384  GLU A OE1 1 
ATOM   807  O  OE2 . GLU A 1 121 ? -13.035 -24.224 -42.797 1.00 46.48  ? 384  GLU A OE2 1 
ATOM   808  N  N   . LEU A 1 122 ? -16.639 -25.187 -37.835 1.00 34.19  ? 385  LEU A N   1 
ATOM   809  C  CA  . LEU A 1 122 ? -17.630 -25.960 -37.040 1.00 31.45  ? 385  LEU A CA  1 
ATOM   810  C  C   . LEU A 1 122 ? -19.038 -25.434 -37.385 1.00 31.60  ? 385  LEU A C   1 
ATOM   811  O  O   . LEU A 1 122 ? -20.000 -26.200 -37.207 1.00 28.97  ? 385  LEU A O   1 
ATOM   812  C  CB  . LEU A 1 122 ? -17.337 -25.835 -35.535 1.00 26.12  ? 385  LEU A CB  1 
ATOM   813  C  CG  . LEU A 1 122 ? -16.030 -26.491 -35.094 1.00 29.36  ? 385  LEU A CG  1 
ATOM   814  C  CD1 . LEU A 1 122 ? -15.729 -26.224 -33.635 1.00 30.87  ? 385  LEU A CD1 1 
ATOM   815  C  CD2 . LEU A 1 122 ? -16.103 -27.977 -35.401 1.00 32.82  ? 385  LEU A CD2 1 
ATOM   816  N  N   . GLY A 1 123 ? -19.129 -24.152 -37.756 1.00 32.38  ? 386  GLY A N   1 
ATOM   817  C  CA  . GLY A 1 123 ? -20.376 -23.414 -38.041 1.00 37.75  ? 386  GLY A CA  1 
ATOM   818  C  C   . GLY A 1 123 ? -20.834 -23.554 -39.489 1.00 43.27  ? 386  GLY A C   1 
ATOM   819  O  O   . GLY A 1 123 ? -21.984 -23.242 -39.737 1.00 44.65  ? 386  GLY A O   1 
ATOM   820  N  N   . LYS A 1 124 ? -20.026 -24.070 -40.417 1.00 40.31  ? 387  LYS A N   1 
ATOM   821  C  CA  . LYS A 1 124 ? -20.459 -24.177 -41.841 1.00 43.06  ? 387  LYS A CA  1 
ATOM   822  C  C   . LYS A 1 124 ? -21.764 -24.976 -42.006 1.00 45.10  ? 387  LYS A C   1 
ATOM   823  O  O   . LYS A 1 124 ? -22.582 -24.611 -42.853 1.00 46.29  ? 387  LYS A O   1 
ATOM   824  C  CB  . LYS A 1 124 ? -19.355 -24.784 -42.693 1.00 42.40  ? 387  LYS A CB  1 
ATOM   825  C  CG  . LYS A 1 124 ? -18.288 -23.804 -43.163 1.00 50.16  ? 387  LYS A CG  1 
ATOM   826  C  CD  . LYS A 1 124 ? -17.355 -24.447 -44.169 1.00 56.50  ? 387  LYS A CD  1 
ATOM   827  C  CE  . LYS A 1 124 ? -15.978 -23.824 -44.261 1.00 57.55  ? 387  LYS A CE  1 
ATOM   828  N  NZ  . LYS A 1 124 ? -15.062 -24.769 -44.955 1.00 64.03  ? 387  LYS A NZ  1 
ATOM   829  N  N   . LYS A 1 125 ? -21.943 -26.081 -41.298 1.00 38.47  ? 388  LYS A N   1 
ATOM   830  C  CA  . LYS A 1 125 ? -23.124 -26.948 -41.457 1.00 39.34  ? 388  LYS A CA  1 
ATOM   831  C  C   . LYS A 1 125 ? -23.993 -26.942 -40.185 1.00 34.98  ? 388  LYS A C   1 
ATOM   832  O  O   . LYS A 1 125 ? -24.776 -27.852 -40.016 1.00 38.34  ? 388  LYS A O   1 
ATOM   833  C  CB  . LYS A 1 125 ? -22.640 -28.350 -41.797 1.00 45.92  ? 388  LYS A CB  1 
ATOM   834  C  CG  . LYS A 1 125 ? -21.995 -28.503 -43.169 1.00 50.86  ? 388  LYS A CG  1 
ATOM   835  C  CD  . LYS A 1 125 ? -21.505 -29.943 -43.433 1.00 63.54  ? 388  LYS A CD  1 
ATOM   836  C  CE  . LYS A 1 125 ? -20.326 -30.383 -42.582 1.00 68.30  ? 388  LYS A CE  1 
ATOM   837  N  NZ  . LYS A 1 125 ? -20.202 -31.863 -42.523 1.00 72.05  ? 388  LYS A NZ  1 
ATOM   838  N  N   . LYS A 1 126 ? -23.824 -25.988 -39.277 1.00 34.51  ? 389  LYS A N   1 
ATOM   839  C  CA  . LYS A 1 126 ? -24.623 -25.948 -38.037 1.00 35.72  ? 389  LYS A CA  1 
ATOM   840  C  C   . LYS A 1 126 ? -25.116 -24.520 -37.830 1.00 41.59  ? 389  LYS A C   1 
ATOM   841  O  O   . LYS A 1 126 ? -24.402 -23.601 -38.264 1.00 45.61  ? 389  LYS A O   1 
ATOM   842  C  CB  . LYS A 1 126 ? -23.767 -26.327 -36.828 1.00 36.08  ? 389  LYS A CB  1 
ATOM   843  C  CG  . LYS A 1 126 ? -23.145 -27.706 -36.903 1.00 35.63  ? 389  LYS A CG  1 
ATOM   844  C  CD  . LYS A 1 126 ? -24.118 -28.746 -36.455 1.00 34.94  ? 389  LYS A CD  1 
ATOM   845  C  CE  . LYS A 1 126 ? -23.494 -30.114 -36.484 1.00 37.42  ? 389  LYS A CE  1 
ATOM   846  N  NZ  . LYS A 1 126 ? -24.544 -31.142 -36.485 1.00 36.49  ? 389  LYS A NZ  1 
ATOM   847  N  N   . THR A 1 127 ? -26.196 -24.344 -37.048 1.00 37.65  ? 390  THR A N   1 
ATOM   848  C  CA  . THR A 1 127 ? -26.760 -23.003 -36.696 1.00 38.08  ? 390  THR A CA  1 
ATOM   849  C  C   . THR A 1 127 ? -26.879 -22.858 -35.193 1.00 29.94  ? 390  THR A C   1 
ATOM   850  O  O   . THR A 1 127 ? -27.662 -23.582 -34.589 1.00 35.67  ? 390  THR A O   1 
ATOM   851  C  CB  . THR A 1 127 ? -28.179 -22.841 -37.279 1.00 47.04  ? 390  THR A CB  1 
ATOM   852  O  OG1 . THR A 1 127 ? -28.032 -22.968 -38.697 1.00 44.13  ? 390  THR A OG1 1 
ATOM   853  C  CG2 . THR A 1 127 ? -28.837 -21.552 -36.834 1.00 41.90  ? 390  THR A CG2 1 
ATOM   854  N  N   . PRO A 1 128 ? -26.129 -21.950 -34.543 1.00 32.49  ? 391  PRO A N   1 
ATOM   855  C  CA  . PRO A 1 128 ? -26.275 -21.737 -33.111 1.00 34.27  ? 391  PRO A CA  1 
ATOM   856  C  C   . PRO A 1 128 ? -27.752 -21.381 -32.850 1.00 38.62  ? 391  PRO A C   1 
ATOM   857  O  O   . PRO A 1 128 ? -28.407 -20.803 -33.721 1.00 37.29  ? 391  PRO A O   1 
ATOM   858  C  CB  . PRO A 1 128 ? -25.335 -20.567 -32.762 1.00 31.09  ? 391  PRO A CB  1 
ATOM   859  C  CG  . PRO A 1 128 ? -24.448 -20.409 -33.971 1.00 34.04  ? 391  PRO A CG  1 
ATOM   860  C  CD  . PRO A 1 128 ? -25.127 -21.055 -35.146 1.00 31.66  ? 391  PRO A CD  1 
ATOM   861  N  N   . ARG A 1 129 ? -28.255 -21.788 -31.697 1.00 37.05  ? 392  ARG A N   1 
ATOM   862  C  CA  . ARG A 1 129 ? -29.668 -21.573 -31.293 1.00 36.11  ? 392  ARG A CA  1 
ATOM   863  C  C   . ARG A 1 129 ? -29.775 -21.770 -29.782 1.00 50.54  ? 392  ARG A C   1 
ATOM   864  O  O   . ARG A 1 129 ? -28.888 -22.450 -29.214 1.00 37.82  ? 392  ARG A O   1 
ATOM   865  C  CB  . ARG A 1 129 ? -30.616 -22.464 -32.094 1.00 37.05  ? 392  ARG A CB  1 
ATOM   866  C  CG  . ARG A 1 129 ? -30.324 -23.957 -32.103 1.00 38.53  ? 392  ARG A CG  1 
ATOM   867  C  CD  . ARG A 1 129 ? -31.212 -24.660 -31.148 1.00 39.05  ? 392  ARG A CD  1 
ATOM   868  N  NE  . ARG A 1 129 ? -30.899 -26.057 -30.885 1.00 37.10  ? 392  ARG A NE  1 
ATOM   869  C  CZ  . ARG A 1 129 ? -31.444 -26.728 -29.881 1.00 37.73  ? 392  ARG A CZ  1 
ATOM   870  N  NH1 . ARG A 1 129 ? -32.397 -26.166 -29.165 1.00 38.13  ? 392  ARG A NH1 1 
ATOM   871  N  NH2 . ARG A 1 129 ? -31.166 -27.997 -29.680 1.00 37.75  ? 392  ARG A NH2 1 
ATOM   872  N  N   . MET A 1 130 ? -30.799 -21.159 -29.160 1.00 45.74  ? 393  MET A N   1 
ATOM   873  C  CA  . MET A 1 130 ? -31.077 -21.291 -27.720 1.00 42.16  ? 393  MET A CA  1 
ATOM   874  C  C   . MET A 1 130 ? -31.714 -22.635 -27.437 1.00 39.46  ? 393  MET A C   1 
ATOM   875  O  O   . MET A 1 130 ? -32.515 -23.130 -28.231 1.00 41.88  ? 393  MET A O   1 
ATOM   876  C  CB  . MET A 1 130 ? -31.990 -20.167 -27.246 1.00 54.15  ? 393  MET A CB  1 
ATOM   877  C  CG  . MET A 1 130 ? -31.340 -18.803 -27.400 1.00 60.75  ? 393  MET A CG  1 
ATOM   878  S  SD  . MET A 1 130 ? -32.248 -17.449 -26.554 1.00 72.96  ? 393  MET A SD  1 
ATOM   879  C  CE  . MET A 1 130 ? -33.904 -17.793 -27.156 1.00 70.68  ? 393  MET A CE  1 
ATOM   880  N  N   . CYS A 1 131 ? -31.311 -23.265 -26.348 1.00 37.00  ? 394  CYS A N   1 
ATOM   881  C  CA  . CYS A 1 131 ? -31.997 -24.467 -25.844 1.00 41.18  ? 394  CYS A CA  1 
ATOM   882  C  C   . CYS A 1 131 ? -33.160 -23.993 -24.937 1.00 42.92  ? 394  CYS A C   1 
ATOM   883  O  O   . CYS A 1 131 ? -33.175 -22.808 -24.547 1.00 44.21  ? 394  CYS A O   1 
ATOM   884  C  CB  . CYS A 1 131 ? -30.989 -25.377 -25.170 1.00 43.04  ? 394  CYS A CB  1 
ATOM   885  S  SG  . CYS A 1 131 ? -29.872 -26.207 -26.329 1.00 43.70  ? 394  CYS A SG  1 
ATOM   886  N  N   . THR A 1 132 ? -34.178 -24.816 -24.715 1.00 47.91  ? 395  THR A N   1 
ATOM   887  C  CA  . THR A 1 132 ? -35.479 -24.307 -24.192 1.00 53.88  ? 395  THR A CA  1 
ATOM   888  C  C   . THR A 1 132 ? -35.761 -24.874 -22.806 1.00 48.74  ? 395  THR A C   1 
ATOM   889  O  O   . THR A 1 132 ? -35.280 -25.994 -22.524 1.00 47.73  ? 395  THR A O   1 
ATOM   890  C  CB  . THR A 1 132 ? -36.622 -24.667 -25.145 1.00 51.97  ? 395  THR A CB  1 
ATOM   891  O  OG1 . THR A 1 132 ? -36.634 -26.084 -25.306 1.00 53.03  ? 395  THR A OG1 1 
ATOM   892  C  CG2 . THR A 1 132 ? -36.484 -23.985 -26.488 1.00 60.07  ? 395  THR A CG2 1 
ATOM   893  N  N   . ARG A 1 133 ? -36.552 -24.143 -22.012 1.00 57.39  ? 396  ARG A N   1 
ATOM   894  C  CA  . ARG A 1 133 ? -37.153 -24.644 -20.736 1.00 54.89  ? 396  ARG A CA  1 
ATOM   895  C  C   . ARG A 1 133 ? -37.706 -26.040 -21.002 1.00 55.79  ? 396  ARG A C   1 
ATOM   896  O  O   . ARG A 1 133 ? -37.428 -26.989 -20.220 1.00 60.50  ? 396  ARG A O   1 
ATOM   897  C  CB  . ARG A 1 133 ? -38.279 -23.735 -20.224 1.00 60.83  ? 396  ARG A CB  1 
ATOM   898  C  CG  . ARG A 1 133 ? -37.995 -22.250 -20.363 1.00 63.13  ? 396  ARG A CG  1 
ATOM   899  C  CD  . ARG A 1 133 ? -38.690 -21.353 -19.359 1.00 71.21  ? 396  ARG A CD  1 
ATOM   900  N  NE  . ARG A 1 133 ? -37.944 -20.108 -19.190 1.00 72.91  ? 396  ARG A NE  1 
ATOM   901  C  CZ  . ARG A 1 133 ? -38.271 -19.130 -18.349 1.00 80.14  ? 396  ARG A CZ  1 
ATOM   902  N  NH1 . ARG A 1 133 ? -39.372 -19.219 -17.619 1.00 81.79  ? 396  ARG A NH1 1 
ATOM   903  N  NH2 . ARG A 1 133 ? -37.510 -18.051 -18.266 1.00 75.40  ? 396  ARG A NH2 1 
ATOM   904  N  N   . GLU A 1 134 ? -38.408 -26.166 -22.127 1.00 56.63  ? 397  GLU A N   1 
ATOM   905  C  CA  . GLU A 1 134 ? -39.018 -27.435 -22.569 1.00 64.56  ? 397  GLU A CA  1 
ATOM   906  C  C   . GLU A 1 134 ? -37.908 -28.489 -22.575 1.00 61.12  ? 397  GLU A C   1 
ATOM   907  O  O   . GLU A 1 134 ? -38.021 -29.417 -21.807 1.00 61.31  ? 397  GLU A O   1 
ATOM   908  C  CB  . GLU A 1 134 ? -39.726 -27.226 -23.911 1.00 73.14  ? 397  GLU A CB  1 
ATOM   909  C  CG  . GLU A 1 134 ? -40.984 -26.355 -23.846 1.00 81.86  ? 397  GLU A CG  1 
ATOM   910  C  CD  . GLU A 1 134 ? -40.870 -24.852 -23.560 1.00 89.42  ? 397  GLU A CD  1 
ATOM   911  O  OE1 . GLU A 1 134 ? -39.827 -24.216 -23.906 1.00 66.08  ? 397  GLU A OE1 1 
ATOM   912  O  OE2 . GLU A 1 134 ? -41.860 -24.291 -23.004 1.00 91.12  ? 397  GLU A OE2 1 
ATOM   913  N  N   . GLU A 1 135 ? -36.827 -28.304 -23.355 1.00 68.06  ? 398  GLU A N   1 
ATOM   914  C  CA  . GLU A 1 135 ? -35.708 -29.294 -23.467 1.00 65.27  ? 398  GLU A CA  1 
ATOM   915  C  C   . GLU A 1 135 ? -35.020 -29.532 -22.115 1.00 66.63  ? 398  GLU A C   1 
ATOM   916  O  O   . GLU A 1 135 ? -34.597 -30.691 -21.859 1.00 57.76  ? 398  GLU A O   1 
ATOM   917  C  CB  . GLU A 1 135 ? -34.600 -28.820 -24.411 1.00 64.35  ? 398  GLU A CB  1 
ATOM   918  C  CG  . GLU A 1 135 ? -34.955 -28.927 -25.878 1.00 64.93  ? 398  GLU A CG  1 
ATOM   919  C  CD  . GLU A 1 135 ? -33.871 -28.392 -26.792 1.00 57.05  ? 398  GLU A CD  1 
ATOM   920  O  OE1 . GLU A 1 135 ? -33.569 -27.188 -26.675 1.00 43.47  ? 398  GLU A OE1 1 
ATOM   921  O  OE2 . GLU A 1 135 ? -33.311 -29.207 -27.587 1.00 57.51  ? 398  GLU A OE2 1 
ATOM   922  N  N   . PHE A 1 136 ? -34.797 -28.458 -21.343 1.00 60.75  ? 399  PHE A N   1 
ATOM   923  C  CA  . PHE A 1 136 ? -34.174 -28.530 -19.995 1.00 65.17  ? 399  PHE A CA  1 
ATOM   924  C  C   . PHE A 1 136 ? -35.031 -29.430 -19.090 1.00 65.59  ? 399  PHE A C   1 
ATOM   925  O  O   . PHE A 1 136 ? -34.474 -30.363 -18.435 1.00 56.95  ? 399  PHE A O   1 
ATOM   926  C  CB  . PHE A 1 136 ? -33.992 -27.132 -19.401 1.00 64.25  ? 399  PHE A CB  1 
ATOM   927  C  CG  . PHE A 1 136 ? -33.178 -27.142 -18.130 1.00 68.46  ? 399  PHE A CG  1 
ATOM   928  C  CD1 . PHE A 1 136 ? -31.828 -27.453 -18.163 1.00 59.65  ? 399  PHE A CD1 1 
ATOM   929  C  CD2 . PHE A 1 136 ? -33.763 -26.865 -16.904 1.00 66.34  ? 399  PHE A CD2 1 
ATOM   930  C  CE1 . PHE A 1 136 ? -31.070 -27.449 -17.006 1.00 60.56  ? 399  PHE A CE1 1 
ATOM   931  C  CE2 . PHE A 1 136 ? -33.005 -26.874 -15.745 1.00 66.45  ? 399  PHE A CE2 1 
ATOM   932  C  CZ  . PHE A 1 136 ? -31.661 -27.167 -15.800 1.00 64.09  ? 399  PHE A CZ  1 
ATOM   933  N  N   . THR A 1 137 ? -36.350 -29.183 -19.086 1.00 64.35  ? 400  THR A N   1 
ATOM   934  C  CA  . THR A 1 137 ? -37.346 -29.949 -18.280 1.00 66.03  ? 400  THR A CA  1 
ATOM   935  C  C   . THR A 1 137 ? -37.250 -31.439 -18.615 1.00 67.02  ? 400  THR A C   1 
ATOM   936  O  O   . THR A 1 137 ? -37.245 -32.245 -17.688 1.00 66.40  ? 400  THR A O   1 
ATOM   937  C  CB  . THR A 1 137 ? -38.764 -29.415 -18.485 1.00 59.39  ? 400  THR A CB  1 
ATOM   938  O  OG1 . THR A 1 137 ? -38.782 -28.124 -17.884 1.00 63.15  ? 400  THR A OG1 1 
ATOM   939  C  CG2 . THR A 1 137 ? -39.836 -30.292 -17.881 1.00 64.14  ? 400  THR A CG2 1 
ATOM   940  N  N   . ARG A 1 138 ? -37.186 -31.792 -19.896 1.00 74.41  ? 401  ARG A N   1 
ATOM   941  C  CA  . ARG A 1 138 ? -37.152 -33.213 -20.321 1.00 77.67  ? 401  ARG A CA  1 
ATOM   942  C  C   . ARG A 1 138 ? -35.867 -33.873 -19.793 1.00 77.72  ? 401  ARG A C   1 
ATOM   943  O  O   . ARG A 1 138 ? -35.921 -35.013 -19.323 1.00 81.20  ? 401  ARG A O   1 
ATOM   944  C  CB  . ARG A 1 138 ? -37.322 -33.300 -21.842 1.00 95.04  ? 401  ARG A CB  1 
ATOM   945  C  CG  . ARG A 1 138 ? -37.656 -34.694 -22.360 1.00 101.74 ? 401  ARG A CG  1 
ATOM   946  C  CD  . ARG A 1 138 ? -38.534 -34.676 -23.605 1.00 100.22 ? 401  ARG A CD  1 
ATOM   947  N  NE  . ARG A 1 138 ? -37.893 -33.970 -24.716 1.00 110.10 ? 401  ARG A NE  1 
ATOM   948  C  CZ  . ARG A 1 138 ? -37.211 -34.526 -25.734 1.00 106.83 ? 401  ARG A CZ  1 
ATOM   949  N  NH1 . ARG A 1 138 ? -37.060 -35.839 -25.836 1.00 101.32 ? 401  ARG A NH1 1 
ATOM   950  N  NH2 . ARG A 1 138 ? -36.673 -33.747 -26.661 1.00 99.61  ? 401  ARG A NH2 1 
ATOM   951  N  N   . LYS A 1 139 ? -34.741 -33.157 -19.860 0.50 78.25  ? 402  LYS A N   1 
ATOM   952  C  CA  . LYS A 1 139 ? -33.409 -33.658 -19.429 0.50 77.76  ? 402  LYS A CA  1 
ATOM   953  C  C   . LYS A 1 139 ? -33.422 -33.929 -17.917 0.50 81.50  ? 402  LYS A C   1 
ATOM   954  O  O   . LYS A 1 139 ? -32.783 -34.917 -17.494 0.50 82.91  ? 402  LYS A O   1 
ATOM   955  C  CB  . LYS A 1 139 ? -32.317 -32.663 -19.833 0.50 76.91  ? 402  LYS A CB  1 
ATOM   956  C  CG  . LYS A 1 139 ? -32.068 -32.564 -21.334 0.50 75.96  ? 402  LYS A CG  1 
ATOM   957  C  CD  . LYS A 1 139 ? -31.021 -31.536 -21.716 0.50 73.79  ? 402  LYS A CD  1 
ATOM   958  C  CE  . LYS A 1 139 ? -29.605 -32.031 -21.514 0.50 72.60  ? 402  LYS A CE  1 
ATOM   959  N  NZ  . LYS A 1 139 ? -29.346 -33.263 -22.297 0.50 72.19  ? 402  LYS A NZ  1 
ATOM   960  N  N   . VAL A 1 140 ? -34.125 -33.097 -17.136 1.00 81.96  ? 403  VAL A N   1 
ATOM   961  C  CA  . VAL A 1 140 ? -34.213 -33.263 -15.650 1.00 83.40  ? 403  VAL A CA  1 
ATOM   962  C  C   . VAL A 1 140 ? -35.140 -34.445 -15.320 1.00 90.03  ? 403  VAL A C   1 
ATOM   963  O  O   . VAL A 1 140 ? -34.832 -35.146 -14.325 1.00 83.70  ? 403  VAL A O   1 
ATOM   964  C  CB  . VAL A 1 140 ? -34.621 -31.982 -14.886 1.00 82.78  ? 403  VAL A CB  1 
ATOM   965  C  CG1 . VAL A 1 140 ? -33.850 -30.756 -15.347 1.00 81.42  ? 403  VAL A CG1 1 
ATOM   966  C  CG2 . VAL A 1 140 ? -36.121 -31.713 -14.893 1.00 85.25  ? 403  VAL A CG2 1 
ATOM   967  N  N   . ARG A 1 141 ? -36.207 -34.671 -16.106 1.00 86.57  ? 404  ARG A N   1 
ATOM   968  C  CA  . ARG A 1 141 ? -37.194 -35.762 -15.856 1.00 87.94  ? 404  ARG A CA  1 
ATOM   969  C  C   . ARG A 1 141 ? -36.659 -37.094 -16.390 1.00 87.45  ? 404  ARG A C   1 
ATOM   970  O  O   . ARG A 1 141 ? -37.377 -38.084 -16.253 1.00 102.77 ? 404  ARG A O   1 
ATOM   971  C  CB  . ARG A 1 141 ? -38.573 -35.431 -16.437 1.00 81.51  ? 404  ARG A CB  1 
ATOM   972  C  CG  . ARG A 1 141 ? -39.295 -34.327 -15.674 1.00 87.57  ? 404  ARG A CG  1 
ATOM   973  C  CD  . ARG A 1 141 ? -40.806 -34.474 -15.642 1.00 96.84  ? 404  ARG A CD  1 
ATOM   974  N  NE  . ARG A 1 141 ? -41.488 -33.950 -16.826 1.00 104.20 ? 404  ARG A NE  1 
ATOM   975  C  CZ  . ARG A 1 141 ? -42.090 -32.757 -16.923 1.00 104.97 ? 404  ARG A CZ  1 
ATOM   976  N  NH1 . ARG A 1 141 ? -42.100 -31.914 -15.901 1.00 100.64 ? 404  ARG A NH1 1 
ATOM   977  N  NH2 . ARG A 1 141 ? -42.685 -32.409 -18.057 1.00 104.53 ? 404  ARG A NH2 1 
ATOM   978  N  N   . SER A 1 142 ? -35.445 -37.124 -16.947 1.00 94.75  ? 405  SER A N   1 
ATOM   979  C  CA  . SER A 1 142 ? -34.751 -38.363 -17.390 1.00 104.31 ? 405  SER A CA  1 
ATOM   980  C  C   . SER A 1 142 ? -33.377 -38.538 -16.707 1.00 110.30 ? 405  SER A C   1 
ATOM   981  O  O   . SER A 1 142 ? -32.538 -39.301 -17.232 1.00 109.80 ? 405  SER A O   1 
ATOM   982  C  CB  . SER A 1 142 ? -34.661 -38.400 -18.906 1.00 106.11 ? 405  SER A CB  1 
ATOM   983  O  OG  . SER A 1 142 ? -34.464 -37.098 -19.445 1.00 100.38 ? 405  SER A OG  1 
ATOM   984  N  N   . ASN A 1 143 ? -33.170 -37.848 -15.577 0.50 113.13 ? 406  ASN A N   1 
ATOM   985  C  CA  . ASN A 1 143 ? -32.021 -38.027 -14.645 0.50 116.98 ? 406  ASN A CA  1 
ATOM   986  C  C   . ASN A 1 143 ? -30.691 -37.920 -15.403 0.50 116.25 ? 406  ASN A C   1 
ATOM   987  O  O   . ASN A 1 143 ? -30.011 -38.957 -15.549 0.50 117.85 ? 406  ASN A O   1 
ATOM   988  C  CB  . ASN A 1 143 ? -32.109 -39.362 -13.897 0.50 118.97 ? 406  ASN A CB  1 
ATOM   989  C  CG  . ASN A 1 143 ? -33.502 -39.672 -13.387 0.50 120.48 ? 406  ASN A CG  1 
ATOM   990  O  OD1 . ASN A 1 143 ? -34.365 -38.797 -13.341 0.50 119.05 ? 406  ASN A OD1 1 
ATOM   991  N  ND2 . ASN A 1 143 ? -33.732 -40.917 -13.005 0.50 120.75 ? 406  ASN A ND2 1 
ATOM   992  N  N   . ALA A 1 144 ? -30.333 -36.713 -15.853 0.50 116.77 ? 407  ALA A N   1 
ATOM   993  C  CA  . ALA A 1 144 ? -29.041 -36.395 -16.506 0.50 117.35 ? 407  ALA A CA  1 
ATOM   994  C  C   . ALA A 1 144 ? -28.230 -35.460 -15.599 0.50 121.15 ? 407  ALA A C   1 
ATOM   995  O  O   . ALA A 1 144 ? -28.753 -34.387 -15.237 0.50 121.63 ? 407  ALA A O   1 
ATOM   996  C  CB  . ALA A 1 144 ? -29.282 -35.777 -17.862 0.50 113.75 ? 407  ALA A CB  1 
ATOM   997  N  N   . ALA A 1 145 ? -27.003 -35.861 -15.245 0.50 121.00 ? 408  ALA A N   1 
ATOM   998  C  CA  . ALA A 1 145 ? -26.066 -35.095 -14.389 0.50 119.72 ? 408  ALA A CA  1 
ATOM   999  C  C   . ALA A 1 145 ? -25.927 -33.665 -14.929 0.50 124.08 ? 408  ALA A C   1 
ATOM   1000 O  O   . ALA A 1 145 ? -25.339 -33.496 -16.017 0.50 125.63 ? 408  ALA A O   1 
ATOM   1001 C  CB  . ALA A 1 145 ? -24.732 -35.799 -14.330 0.50 115.74 ? 408  ALA A CB  1 
ATOM   1002 N  N   . LEU A 1 146 ? -26.461 -32.681 -14.194 0.50 125.59 ? 409  LEU A N   1 
ATOM   1003 C  CA  . LEU A 1 146 ? -26.414 -31.234 -14.544 0.50 123.88 ? 409  LEU A CA  1 
ATOM   1004 C  C   . LEU A 1 146 ? -25.626 -30.449 -13.486 0.50 121.55 ? 409  LEU A C   1 
ATOM   1005 O  O   . LEU A 1 146 ? -25.647 -29.202 -13.557 0.50 119.25 ? 409  LEU A O   1 
ATOM   1006 C  CB  . LEU A 1 146 ? -27.846 -30.698 -14.648 0.50 124.06 ? 409  LEU A CB  1 
ATOM   1007 C  CG  . LEU A 1 146 ? -28.739 -31.397 -15.671 0.50 124.87 ? 409  LEU A CG  1 
ATOM   1008 C  CD1 . LEU A 1 146 ? -30.117 -30.757 -15.709 0.50 123.71 ? 409  LEU A CD1 1 
ATOM   1009 C  CD2 . LEU A 1 146 ? -28.105 -31.376 -17.053 0.50 126.43 ? 409  LEU A CD2 1 
ATOM   1010 N  N   . GLY A 1 147 ? -24.969 -31.144 -12.547 1.00 118.43 ? 410  GLY A N   1 
ATOM   1011 C  CA  . GLY A 1 147 ? -24.215 -30.513 -11.440 1.00 115.00 ? 410  GLY A CA  1 
ATOM   1012 C  C   . GLY A 1 147 ? -25.029 -29.477 -10.668 1.00 111.97 ? 410  GLY A C   1 
ATOM   1013 O  O   . GLY A 1 147 ? -24.528 -28.352 -10.528 1.00 96.09  ? 410  GLY A O   1 
ATOM   1014 N  N   . ALA A 1 148 ? -26.228 -29.834 -10.183 1.00 110.73 ? 411  ALA A N   1 
ATOM   1015 C  CA  . ALA A 1 148 ? -27.144 -28.949 -9.417  1.00 114.43 ? 411  ALA A CA  1 
ATOM   1016 C  C   . ALA A 1 148 ? -26.892 -29.112 -7.906  1.00 120.59 ? 411  ALA A C   1 
ATOM   1017 O  O   . ALA A 1 148 ? -26.117 -30.005 -7.513  1.00 114.15 ? 411  ALA A O   1 
ATOM   1018 C  CB  . ALA A 1 148 ? -28.574 -29.248 -9.788  1.00 105.74 ? 411  ALA A CB  1 
ATOM   1019 N  N   . ILE A 1 149 ? -27.508 -28.237 -7.102  0.50 120.76 ? 412  ILE A N   1 
ATOM   1020 C  CA  . ILE A 1 149 ? -27.376 -28.183 -5.614  0.50 121.00 ? 412  ILE A CA  1 
ATOM   1021 C  C   . ILE A 1 149 ? -28.776 -28.050 -5.004  0.50 122.79 ? 412  ILE A C   1 
ATOM   1022 O  O   . ILE A 1 149 ? -29.429 -27.025 -5.293  0.50 124.92 ? 412  ILE A O   1 
ATOM   1023 C  CB  . ILE A 1 149 ? -26.456 -27.023 -5.183  0.50 120.94 ? 412  ILE A CB  1 
ATOM   1024 C  CG1 . ILE A 1 149 ? -27.093 -25.659 -5.463  0.50 121.45 ? 412  ILE A CG1 1 
ATOM   1025 C  CG2 . ILE A 1 149 ? -25.084 -27.148 -5.829  0.50 122.11 ? 412  ILE A CG2 1 
ATOM   1026 C  CD1 . ILE A 1 149 ? -26.226 -24.481 -5.081  0.50 120.87 ? 412  ILE A CD1 1 
ATOM   1027 N  N   . TRP A 1 156 ? -37.314 -26.351 -2.801  0.50 64.50  ? 419  TRP A N   1 
ATOM   1028 C  CA  . TRP A 1 156 ? -37.497 -27.583 -3.617  0.50 66.36  ? 419  TRP A CA  1 
ATOM   1029 C  C   . TRP A 1 156 ? -36.418 -28.604 -3.248  0.50 70.41  ? 419  TRP A C   1 
ATOM   1030 O  O   . TRP A 1 156 ? -35.258 -28.195 -3.024  0.50 68.26  ? 419  TRP A O   1 
ATOM   1031 C  CB  . TRP A 1 156 ? -37.465 -27.262 -5.120  0.50 64.73  ? 419  TRP A CB  1 
ATOM   1032 C  CG  . TRP A 1 156 ? -38.246 -26.043 -5.501  0.50 59.51  ? 419  TRP A CG  1 
ATOM   1033 C  CD1 . TRP A 1 156 ? -39.599 -25.945 -5.646  0.50 58.89  ? 419  TRP A CD1 1 
ATOM   1034 C  CD2 . TRP A 1 156 ? -37.715 -24.731 -5.767  0.50 57.33  ? 419  TRP A CD2 1 
ATOM   1035 N  NE1 . TRP A 1 156 ? -39.947 -24.666 -5.990  0.50 58.25  ? 419  TRP A NE1 1 
ATOM   1036 C  CE2 . TRP A 1 156 ? -38.813 -23.899 -6.073  0.50 55.83  ? 419  TRP A CE2 1 
ATOM   1037 C  CE3 . TRP A 1 156 ? -36.427 -24.183 -5.786  0.50 55.06  ? 419  TRP A CE3 1 
ATOM   1038 C  CZ2 . TRP A 1 156 ? -38.657 -22.552 -6.388  0.50 56.67  ? 419  TRP A CZ2 1 
ATOM   1039 C  CZ3 . TRP A 1 156 ? -36.273 -22.852 -6.101  0.50 54.82  ? 419  TRP A CZ3 1 
ATOM   1040 C  CH2 . TRP A 1 156 ? -37.376 -22.048 -6.391  0.50 57.89  ? 419  TRP A CH2 1 
ATOM   1041 N  N   . LYS A 1 157 ? -36.795 -29.884 -3.201  0.50 77.40  ? 420  LYS A N   1 
ATOM   1042 C  CA  . LYS A 1 157 ? -35.898 -31.019 -2.861  0.50 81.13  ? 420  LYS A CA  1 
ATOM   1043 C  C   . LYS A 1 157 ? -35.001 -31.328 -4.065  0.50 82.23  ? 420  LYS A C   1 
ATOM   1044 O  O   . LYS A 1 157 ? -33.891 -30.763 -4.141  0.50 87.49  ? 420  LYS A O   1 
ATOM   1045 C  CB  . LYS A 1 157 ? -36.737 -32.237 -2.466  0.50 83.15  ? 420  LYS A CB  1 
ATOM   1046 C  CG  . LYS A 1 157 ? -35.966 -33.533 -2.258  0.50 83.40  ? 420  LYS A CG  1 
ATOM   1047 C  CD  . LYS A 1 157 ? -36.878 -34.726 -2.064  0.50 83.75  ? 420  LYS A CD  1 
ATOM   1048 C  CE  . LYS A 1 157 ? -38.049 -34.419 -1.154  0.50 79.85  ? 420  LYS A CE  1 
ATOM   1049 N  NZ  . LYS A 1 157 ? -39.150 -35.394 -1.326  0.50 78.78  ? 420  LYS A NZ  1 
ATOM   1050 N  N   . SER A 1 158 ? -35.485 -32.187 -4.967  0.50 79.71  ? 421  SER A N   1 
ATOM   1051 C  CA  . SER A 1 158 ? -34.778 -32.643 -6.191  0.50 76.05  ? 421  SER A CA  1 
ATOM   1052 C  C   . SER A 1 158 ? -34.932 -31.596 -7.297  0.50 74.58  ? 421  SER A C   1 
ATOM   1053 O  O   . SER A 1 158 ? -35.716 -30.638 -7.107  0.50 72.70  ? 421  SER A O   1 
ATOM   1054 C  CB  . SER A 1 158 ? -35.297 -33.982 -6.642  0.50 74.29  ? 421  SER A CB  1 
ATOM   1055 O  OG  . SER A 1 158 ? -36.698 -33.927 -6.863  0.50 75.91  ? 421  SER A OG  1 
ATOM   1056 N  N   . ALA A 1 159 ? -34.212 -31.790 -8.406  0.50 72.18  ? 422  ALA A N   1 
ATOM   1057 C  CA  . ALA A 1 159 ? -34.303 -30.971 -9.636  0.50 69.38  ? 422  ALA A CA  1 
ATOM   1058 C  C   . ALA A 1 159 ? -35.727 -31.070 -10.196 0.50 64.72  ? 422  ALA A C   1 
ATOM   1059 O  O   . ALA A 1 159 ? -36.270 -30.042 -10.641 0.50 57.94  ? 422  ALA A O   1 
ATOM   1060 C  CB  . ALA A 1 159 ? -33.276 -31.443 -10.638 0.50 70.53  ? 422  ALA A CB  1 
ATOM   1061 N  N   . ARG A 1 160 ? -36.315 -32.266 -10.133 0.50 65.06  ? 423  ARG A N   1 
ATOM   1062 C  CA  . ARG A 1 160 ? -37.646 -32.581 -10.713 0.50 68.47  ? 423  ARG A CA  1 
ATOM   1063 C  C   . ARG A 1 160 ? -38.712 -31.617 -10.168 0.50 72.12  ? 423  ARG A C   1 
ATOM   1064 O  O   . ARG A 1 160 ? -39.577 -31.190 -10.961 0.50 71.13  ? 423  ARG A O   1 
ATOM   1065 C  CB  . ARG A 1 160 ? -38.001 -34.040 -10.418 0.50 70.18  ? 423  ARG A CB  1 
ATOM   1066 C  CG  . ARG A 1 160 ? -39.003 -34.648 -11.389 0.50 73.44  ? 423  ARG A CG  1 
ATOM   1067 C  CD  . ARG A 1 160 ? -39.253 -36.122 -11.115 0.50 75.28  ? 423  ARG A CD  1 
ATOM   1068 N  NE  . ARG A 1 160 ? -38.048 -36.930 -11.253 0.50 75.07  ? 423  ARG A NE  1 
ATOM   1069 C  CZ  . ARG A 1 160 ? -37.808 -37.745 -12.273 0.50 75.05  ? 423  ARG A CZ  1 
ATOM   1070 N  NH1 . ARG A 1 160 ? -36.683 -38.437 -12.322 0.50 72.08  ? 423  ARG A NH1 1 
ATOM   1071 N  NH2 . ARG A 1 160 ? -38.699 -37.864 -13.241 0.50 77.04  ? 423  ARG A NH2 1 
ATOM   1072 N  N   . GLU A 1 161 ? -38.668 -31.282 -8.872  0.50 74.14  ? 424  GLU A N   1 
ATOM   1073 C  CA  . GLU A 1 161 ? -39.751 -30.518 -8.187  0.50 75.04  ? 424  GLU A CA  1 
ATOM   1074 C  C   . GLU A 1 161 ? -39.565 -29.009 -8.410  0.50 71.94  ? 424  GLU A C   1 
ATOM   1075 O  O   . GLU A 1 161 ? -40.572 -28.277 -8.348  0.50 70.25  ? 424  GLU A O   1 
ATOM   1076 C  CB  . GLU A 1 161 ? -39.810 -30.877 -6.698  0.50 78.71  ? 424  GLU A CB  1 
ATOM   1077 C  CG  . GLU A 1 161 ? -40.437 -32.238 -6.426  0.50 79.53  ? 424  GLU A CG  1 
ATOM   1078 C  CD  . GLU A 1 161 ? -40.915 -32.465 -4.999  0.50 80.78  ? 424  GLU A CD  1 
ATOM   1079 O  OE1 . GLU A 1 161 ? -41.048 -31.471 -4.252  0.50 80.83  ? 424  GLU A OE1 1 
ATOM   1080 O  OE2 . GLU A 1 161 ? -41.159 -33.635 -4.638  0.50 77.51  ? 424  GLU A OE2 1 
ATOM   1081 N  N   . ALA A 1 162 ? -38.335 -28.555 -8.673  0.50 69.99  ? 425  ALA A N   1 
ATOM   1082 C  CA  . ALA A 1 162 ? -38.009 -27.133 -8.935  0.50 67.79  ? 425  ALA A CA  1 
ATOM   1083 C  C   . ALA A 1 162 ? -38.532 -26.734 -10.320 0.50 67.77  ? 425  ALA A C   1 
ATOM   1084 O  O   . ALA A 1 162 ? -38.924 -25.562 -10.502 0.50 65.56  ? 425  ALA A O   1 
ATOM   1085 C  CB  . ALA A 1 162 ? -36.519 -26.918 -8.826  0.50 68.05  ? 425  ALA A CB  1 
ATOM   1086 N  N   . VAL A 1 163 ? -38.550 -27.693 -11.248 0.50 69.37  ? 426  VAL A N   1 
ATOM   1087 C  CA  . VAL A 1 163 ? -38.820 -27.487 -12.702 0.50 73.83  ? 426  VAL A CA  1 
ATOM   1088 C  C   . VAL A 1 163 ? -40.332 -27.427 -12.948 0.50 76.37  ? 426  VAL A C   1 
ATOM   1089 O  O   . VAL A 1 163 ? -40.736 -26.831 -13.959 0.50 75.78  ? 426  VAL A O   1 
ATOM   1090 C  CB  . VAL A 1 163 ? -38.160 -28.605 -13.532 0.50 74.77  ? 426  VAL A CB  1 
ATOM   1091 C  CG1 . VAL A 1 163 ? -38.966 -28.941 -14.773 0.50 75.52  ? 426  VAL A CG1 1 
ATOM   1092 C  CG2 . VAL A 1 163 ? -36.722 -28.264 -13.896 0.50 75.83  ? 426  VAL A CG2 1 
ATOM   1093 N  N   . GLU A 1 164 ? -41.133 -28.022 -12.059 0.50 83.88  ? 427  GLU A N   1 
ATOM   1094 C  CA  . GLU A 1 164 ? -42.611 -28.134 -12.211 0.50 88.96  ? 427  GLU A CA  1 
ATOM   1095 C  C   . GLU A 1 164 ? -43.301 -27.007 -11.427 0.50 92.41  ? 427  GLU A C   1 
ATOM   1096 O  O   . GLU A 1 164 ? -44.541 -26.897 -11.518 0.50 95.04  ? 427  GLU A O   1 
ATOM   1097 C  CB  . GLU A 1 164 ? -43.075 -29.523 -11.769 0.50 89.10  ? 427  GLU A CB  1 
ATOM   1098 C  CG  . GLU A 1 164 ? -42.538 -30.640 -12.649 0.50 91.16  ? 427  GLU A CG  1 
ATOM   1099 C  CD  . GLU A 1 164 ? -42.872 -32.054 -12.197 0.50 95.76  ? 427  GLU A CD  1 
ATOM   1100 O  OE1 . GLU A 1 164 ? -43.767 -32.207 -11.341 0.50 101.21 ? 427  GLU A OE1 1 
ATOM   1101 O  OE2 . GLU A 1 164 ? -42.235 -33.002 -12.701 0.50 94.34  ? 427  GLU A OE2 1 
ATOM   1102 N  N   . ASP A 1 165 ? -42.524 -26.196 -10.701 0.50 92.26  ? 428  ASP A N   1 
ATOM   1103 C  CA  . ASP A 1 165 ? -43.009 -24.996 -9.966  0.50 91.63  ? 428  ASP A CA  1 
ATOM   1104 C  C   . ASP A 1 165 ? -42.647 -23.744 -10.773 0.50 90.22  ? 428  ASP A C   1 
ATOM   1105 O  O   . ASP A 1 165 ? -41.607 -23.763 -11.456 0.50 96.00  ? 428  ASP A O   1 
ATOM   1106 C  CB  . ASP A 1 165 ? -42.432 -24.938 -8.549  0.50 92.58  ? 428  ASP A CB  1 
ATOM   1107 C  CG  . ASP A 1 165 ? -42.713 -23.629 -7.831  0.50 92.03  ? 428  ASP A CG  1 
ATOM   1108 O  OD1 . ASP A 1 165 ? -42.395 -22.569 -8.405  0.50 88.14  ? 428  ASP A OD1 1 
ATOM   1109 O  OD2 . ASP A 1 165 ? -43.256 -23.680 -6.708  0.50 93.77  ? 428  ASP A OD2 1 
ATOM   1110 N  N   . SER A 1 166 ? -43.473 -22.694 -10.708 0.50 87.27  ? 429  SER A N   1 
ATOM   1111 C  CA  . SER A 1 166 ? -43.274 -21.515 -11.596 0.50 83.02  ? 429  SER A CA  1 
ATOM   1112 C  C   . SER A 1 166 ? -42.437 -20.400 -10.960 0.50 80.13  ? 429  SER A C   1 
ATOM   1113 O  O   . SER A 1 166 ? -41.839 -19.618 -11.715 0.50 77.67  ? 429  SER A O   1 
ATOM   1114 C  CB  . SER A 1 166 ? -44.613 -20.992 -12.035 0.50 86.71  ? 429  SER A CB  1 
ATOM   1115 O  OG  . SER A 1 166 ? -45.413 -22.042 -12.556 0.50 89.59  ? 429  SER A OG  1 
ATOM   1116 N  N   . GLY A 1 167 ? -42.415 -20.313 -9.632  1.00 83.37  ? 430  GLY A N   1 
ATOM   1117 C  CA  . GLY A 1 167 ? -41.612 -19.278 -8.954  1.00 77.12  ? 430  GLY A CA  1 
ATOM   1118 C  C   . GLY A 1 167 ? -40.158 -19.411 -9.346  1.00 73.07  ? 430  GLY A C   1 
ATOM   1119 O  O   . GLY A 1 167 ? -39.524 -18.382 -9.591  1.00 69.40  ? 430  GLY A O   1 
ATOM   1120 N  N   . PHE A 1 168 ? -39.660 -20.644 -9.406  1.00 72.21  ? 431  PHE A N   1 
ATOM   1121 C  CA  . PHE A 1 168 ? -38.279 -20.895 -9.881  1.00 74.82  ? 431  PHE A CA  1 
ATOM   1122 C  C   . PHE A 1 168 ? -38.078 -20.169 -11.202 1.00 70.69  ? 431  PHE A C   1 
ATOM   1123 O  O   . PHE A 1 168 ? -37.134 -19.383 -11.326 1.00 63.92  ? 431  PHE A O   1 
ATOM   1124 C  CB  . PHE A 1 168 ? -38.097 -22.397 -10.089 1.00 82.22  ? 431  PHE A CB  1 
ATOM   1125 C  CG  . PHE A 1 168 ? -36.839 -22.833 -10.796 1.00 80.98  ? 431  PHE A CG  1 
ATOM   1126 C  CD1 . PHE A 1 168 ? -35.660 -23.023 -10.095 1.00 82.74  ? 431  PHE A CD1 1 
ATOM   1127 C  CD2 . PHE A 1 168 ? -36.846 -23.096 -12.155 1.00 88.01  ? 431  PHE A CD2 1 
ATOM   1128 C  CE1 . PHE A 1 168 ? -34.509 -23.440 -10.744 1.00 84.35  ? 431  PHE A CE1 1 
ATOM   1129 C  CE2 . PHE A 1 168 ? -35.695 -23.511 -12.804 1.00 90.50  ? 431  PHE A CE2 1 
ATOM   1130 C  CZ  . PHE A 1 168 ? -34.529 -23.684 -12.096 1.00 90.75  ? 431  PHE A CZ  1 
ATOM   1131 N  N   . TRP A 1 169 ? -38.967 -20.420 -12.161 1.00 71.99  ? 432  TRP A N   1 
ATOM   1132 C  CA  . TRP A 1 169 ? -38.788 -19.815 -13.504 1.00 61.29  ? 432  TRP A CA  1 
ATOM   1133 C  C   . TRP A 1 169 ? -38.834 -18.285 -13.389 1.00 69.08  ? 432  TRP A C   1 
ATOM   1134 O  O   . TRP A 1 169 ? -38.235 -17.617 -14.240 1.00 70.41  ? 432  TRP A O   1 
ATOM   1135 C  CB  . TRP A 1 169 ? -39.791 -20.416 -14.493 1.00 58.15  ? 432  TRP A CB  1 
ATOM   1136 C  CG  . TRP A 1 169 ? -39.570 -21.881 -14.709 1.00 59.00  ? 432  TRP A CG  1 
ATOM   1137 C  CD1 . TRP A 1 169 ? -40.335 -22.908 -14.242 1.00 58.87  ? 432  TRP A CD1 1 
ATOM   1138 C  CD2 . TRP A 1 169 ? -38.481 -22.489 -15.426 1.00 60.20  ? 432  TRP A CD2 1 
ATOM   1139 N  NE1 . TRP A 1 169 ? -39.809 -24.109 -14.631 1.00 58.91  ? 432  TRP A NE1 1 
ATOM   1140 C  CE2 . TRP A 1 169 ? -38.670 -23.884 -15.357 1.00 55.91  ? 432  TRP A CE2 1 
ATOM   1141 C  CE3 . TRP A 1 169 ? -37.375 -21.993 -16.123 1.00 60.80  ? 432  TRP A CE3 1 
ATOM   1142 C  CZ2 . TRP A 1 169 ? -37.794 -24.783 -15.960 1.00 58.63  ? 432  TRP A CZ2 1 
ATOM   1143 C  CZ3 . TRP A 1 169 ? -36.510 -22.883 -16.718 1.00 61.41  ? 432  TRP A CZ3 1 
ATOM   1144 C  CH2 . TRP A 1 169 ? -36.718 -24.259 -16.637 1.00 54.88  ? 432  TRP A CH2 1 
ATOM   1145 N  N   . GLU A 1 170 ? -39.468 -17.751 -12.341 1.00 71.52  ? 433  GLU A N   1 
ATOM   1146 C  CA  . GLU A 1 170 ? -39.474 -16.278 -12.131 1.00 73.99  ? 433  GLU A CA  1 
ATOM   1147 C  C   . GLU A 1 170 ? -38.098 -15.886 -11.596 1.00 64.59  ? 433  GLU A C   1 
ATOM   1148 O  O   . GLU A 1 170 ? -37.629 -14.785 -11.911 1.00 70.11  ? 433  GLU A O   1 
ATOM   1149 C  CB  . GLU A 1 170 ? -40.615 -15.856 -11.197 1.00 74.61  ? 433  GLU A CB  1 
ATOM   1150 C  CG  . GLU A 1 170 ? -41.936 -16.530 -11.519 1.00 86.18  ? 433  GLU A CG  1 
ATOM   1151 C  CD  . GLU A 1 170 ? -43.047 -16.309 -10.506 1.00 100.60 ? 433  GLU A CD  1 
ATOM   1152 O  OE1 . GLU A 1 170 ? -43.048 -15.248 -9.851  1.00 97.83  ? 433  GLU A OE1 1 
ATOM   1153 O  OE2 . GLU A 1 170 ? -43.908 -17.202 -10.371 1.00 93.34  ? 433  GLU A OE2 1 
ATOM   1154 N  N   . LEU A 1 171 ? -37.483 -16.766 -10.814 1.00 65.10  ? 434  LEU A N   1 
ATOM   1155 C  CA  . LEU A 1 171 ? -36.101 -16.506 -10.347 1.00 68.56  ? 434  LEU A CA  1 
ATOM   1156 C  C   . LEU A 1 171 ? -35.193 -16.532 -11.577 1.00 64.10  ? 434  LEU A C   1 
ATOM   1157 O  O   . LEU A 1 171 ? -34.362 -15.622 -11.711 1.00 57.57  ? 434  LEU A O   1 
ATOM   1158 C  CB  . LEU A 1 171 ? -35.722 -17.597 -9.345  1.00 66.88  ? 434  LEU A CB  1 
ATOM   1159 C  CG  . LEU A 1 171 ? -36.671 -17.768 -8.162  1.00 71.07  ? 434  LEU A CG  1 
ATOM   1160 C  CD1 . LEU A 1 171 ? -36.172 -18.859 -7.230  1.00 75.60  ? 434  LEU A CD1 1 
ATOM   1161 C  CD2 . LEU A 1 171 ? -36.831 -16.459 -7.409  1.00 66.55  ? 434  LEU A CD2 1 
ATOM   1162 N  N   . VAL A 1 172 ? -35.395 -17.514 -12.458 1.00 62.05  ? 435  VAL A N   1 
ATOM   1163 C  CA  . VAL A 1 172 ? -34.606 -17.608 -13.720 1.00 60.56  ? 435  VAL A CA  1 
ATOM   1164 C  C   . VAL A 1 172 ? -34.813 -16.323 -14.513 1.00 53.87  ? 435  VAL A C   1 
ATOM   1165 O  O   . VAL A 1 172 ? -33.823 -15.730 -14.950 1.00 57.92  ? 435  VAL A O   1 
ATOM   1166 C  CB  . VAL A 1 172 ? -35.033 -18.843 -14.530 1.00 67.38  ? 435  VAL A CB  1 
ATOM   1167 C  CG1 . VAL A 1 172 ? -34.306 -18.927 -15.861 1.00 69.34  ? 435  VAL A CG1 1 
ATOM   1168 C  CG2 . VAL A 1 172 ? -34.860 -20.127 -13.735 1.00 65.00  ? 435  VAL A CG2 1 
ATOM   1169 N  N   . ASP A 1 173 ? -36.061 -15.882 -14.629 1.00 63.47  ? 436  ASP A N   1 
ATOM   1170 C  CA  . ASP A 1 173 ? -36.365 -14.669 -15.429 1.00 65.72  ? 436  ASP A CA  1 
ATOM   1171 C  C   . ASP A 1 173 ? -35.636 -13.460 -14.834 1.00 60.96  ? 436  ASP A C   1 
ATOM   1172 O  O   . ASP A 1 173 ? -35.082 -12.672 -15.607 1.00 57.76  ? 436  ASP A O   1 
ATOM   1173 C  CB  . ASP A 1 173 ? -37.876 -14.472 -15.569 1.00 79.33  ? 436  ASP A CB  1 
ATOM   1174 C  CG  . ASP A 1 173 ? -38.522 -15.485 -16.497 1.00 84.17  ? 436  ASP A CG  1 
ATOM   1175 O  OD1 . ASP A 1 173 ? -37.959 -15.722 -17.581 1.00 79.12  ? 436  ASP A OD1 1 
ATOM   1176 O  OD2 . ASP A 1 173 ? -39.576 -16.033 -16.125 1.00 89.68  ? 436  ASP A OD2 1 
ATOM   1177 N  N   . LYS A 1 174 ? -35.622 -13.329 -13.512 1.00 61.65  ? 437  LYS A N   1 
ATOM   1178 C  CA  . LYS A 1 174 ? -35.003 -12.116 -12.923 1.00 65.77  ? 437  LYS A CA  1 
ATOM   1179 C  C   . LYS A 1 174 ? -33.516 -12.131 -13.256 1.00 63.72  ? 437  LYS A C   1 
ATOM   1180 O  O   . LYS A 1 174 ? -32.994 -11.096 -13.692 1.00 70.06  ? 437  LYS A O   1 
ATOM   1181 C  CB  . LYS A 1 174 ? -35.219 -12.060 -11.410 1.00 73.67  ? 437  LYS A CB  1 
ATOM   1182 C  CG  . LYS A 1 174 ? -34.529 -10.920 -10.676 1.00 79.74  ? 437  LYS A CG  1 
ATOM   1183 C  CD  . LYS A 1 174 ? -34.771 -10.974 -9.179  1.00 81.59  ? 437  LYS A CD  1 
ATOM   1184 C  CE  . LYS A 1 174 ? -34.012 -9.924  -8.397  1.00 80.02  ? 437  LYS A CE  1 
ATOM   1185 N  NZ  . LYS A 1 174 ? -34.283 -10.031 -6.944  1.00 88.70  ? 437  LYS A NZ  1 
ATOM   1186 N  N   . GLU A 1 175 ? -32.875 -13.279 -13.059 1.00 61.49  ? 438  GLU A N   1 
ATOM   1187 C  CA  . GLU A 1 175 ? -31.425 -13.388 -13.378 1.00 60.45  ? 438  GLU A CA  1 
ATOM   1188 C  C   . GLU A 1 175 ? -31.240 -13.205 -14.886 1.00 53.55  ? 438  GLU A C   1 
ATOM   1189 O  O   . GLU A 1 175 ? -30.320 -12.443 -15.281 1.00 56.09  ? 438  GLU A O   1 
ATOM   1190 C  CB  . GLU A 1 175 ? -30.864 -14.717 -12.878 1.00 64.51  ? 438  GLU A CB  1 
ATOM   1191 C  CG  . GLU A 1 175 ? -30.037 -14.549 -11.617 1.00 69.86  ? 438  GLU A CG  1 
ATOM   1192 C  CD  . GLU A 1 175 ? -28.619 -14.103 -11.890 1.00 59.01  ? 438  GLU A CD  1 
ATOM   1193 O  OE1 . GLU A 1 175 ? -27.811 -14.938 -12.332 1.00 69.06  ? 438  GLU A OE1 1 
ATOM   1194 O  OE2 . GLU A 1 175 ? -28.333 -12.930 -11.678 1.00 67.27  ? 438  GLU A OE2 1 
ATOM   1195 N  N   . ARG A 1 176 ? -32.100 -13.855 -15.686 1.00 55.19  ? 439  ARG A N   1 
ATOM   1196 C  CA  . ARG A 1 176 ? -32.072 -13.761 -17.174 1.00 55.32  ? 439  ARG A CA  1 
ATOM   1197 C  C   . ARG A 1 176 ? -32.062 -12.288 -17.582 1.00 60.05  ? 439  ARG A C   1 
ATOM   1198 O  O   . ARG A 1 176 ? -31.169 -11.896 -18.381 1.00 58.72  ? 439  ARG A O   1 
ATOM   1199 C  CB  . ARG A 1 176 ? -33.257 -14.522 -17.756 1.00 56.43  ? 439  ARG A CB  1 
ATOM   1200 C  CG  . ARG A 1 176 ? -33.258 -14.575 -19.274 1.00 59.70  ? 439  ARG A CG  1 
ATOM   1201 C  CD  . ARG A 1 176 ? -34.042 -15.785 -19.734 1.00 55.30  ? 439  ARG A CD  1 
ATOM   1202 N  NE  . ARG A 1 176 ? -34.095 -15.758 -21.176 1.00 71.77  ? 439  ARG A NE  1 
ATOM   1203 C  CZ  . ARG A 1 176 ? -34.797 -16.588 -21.924 1.00 82.06  ? 439  ARG A CZ  1 
ATOM   1204 N  NH1 . ARG A 1 176 ? -35.508 -17.547 -21.346 1.00 87.23  ? 439  ARG A NH1 1 
ATOM   1205 N  NH2 . ARG A 1 176 ? -34.765 -16.456 -23.245 1.00 75.53  ? 439  ARG A NH2 1 
ATOM   1206 N  N   . ASN A 1 177 ? -32.964 -11.479 -17.001 1.00 65.43  ? 440  ASN A N   1 
ATOM   1207 C  CA  . ASN A 1 177 ? -33.085 -10.021 -17.300 1.00 62.16  ? 440  ASN A CA  1 
ATOM   1208 C  C   . ASN A 1 177 ? -31.837 -9.271  -16.825 1.00 62.60  ? 440  ASN A C   1 
ATOM   1209 O  O   . ASN A 1 177 ? -31.413 -8.325  -17.507 1.00 62.97  ? 440  ASN A O   1 
ATOM   1210 C  CB  . ASN A 1 177 ? -34.419 -9.444  -16.810 1.00 68.30  ? 440  ASN A CB  1 
ATOM   1211 C  CG  . ASN A 1 177 ? -35.545 -9.849  -17.742 1.00 65.93  ? 440  ASN A CG  1 
ATOM   1212 O  OD1 . ASN A 1 177 ? -35.714 -9.277  -18.819 1.00 74.75  ? 440  ASN A OD1 1 
ATOM   1213 N  ND2 . ASN A 1 177 ? -36.261 -10.898 -17.389 1.00 64.01  ? 440  ASN A ND2 1 
ATOM   1214 N  N   . LEU A 1 178 ? -31.256 -9.691  -15.696 0.50 66.41  ? 441  LEU A N   1 
ATOM   1215 C  CA  . LEU A 1 178 ? -30.001 -9.114  -15.142 0.50 68.31  ? 441  LEU A CA  1 
ATOM   1216 C  C   . LEU A 1 178 ? -28.845 -9.349  -16.123 0.50 67.44  ? 441  LEU A C   1 
ATOM   1217 O  O   . LEU A 1 178 ? -28.056 -8.402  -16.337 0.50 67.40  ? 441  LEU A O   1 
ATOM   1218 C  CB  . LEU A 1 178 ? -29.716 -9.736  -13.772 0.50 73.09  ? 441  LEU A CB  1 
ATOM   1219 C  CG  . LEU A 1 178 ? -30.559 -9.185  -12.622 0.50 76.29  ? 441  LEU A CG  1 
ATOM   1220 C  CD1 . LEU A 1 178 ? -30.230 -9.893  -11.314 0.50 77.35  ? 441  LEU A CD1 1 
ATOM   1221 C  CD2 . LEU A 1 178 ? -30.367 -7.682  -12.484 0.50 77.92  ? 441  LEU A CD2 1 
ATOM   1222 N  N   . HIS A 1 179 ? -28.754 -10.553 -16.701 1.00 65.20  ? 442  HIS A N   1 
ATOM   1223 C  CA  . HIS A 1 179 ? -27.732 -10.892 -17.740 1.00 66.98  ? 442  HIS A CA  1 
ATOM   1224 C  C   . HIS A 1 179 ? -27.896 -10.009 -19.001 1.00 65.24  ? 442  HIS A C   1 
ATOM   1225 O  O   . HIS A 1 179 ? -26.865 -9.476  -19.475 1.00 64.49  ? 442  HIS A O   1 
ATOM   1226 C  CB  . HIS A 1 179 ? -27.757 -12.390 -18.103 1.00 63.63  ? 442  HIS A CB  1 
ATOM   1227 C  CG  . HIS A 1 179 ? -27.236 -13.309 -17.043 1.00 59.38  ? 442  HIS A CG  1 
ATOM   1228 N  ND1 . HIS A 1 179 ? -27.393 -14.679 -17.115 1.00 60.12  ? 442  HIS A ND1 1 
ATOM   1229 C  CD2 . HIS A 1 179 ? -26.560 -13.061 -15.903 1.00 55.62  ? 442  HIS A CD2 1 
ATOM   1230 C  CE1 . HIS A 1 179 ? -26.865 -15.227 -16.041 1.00 60.43  ? 442  HIS A CE1 1 
ATOM   1231 N  NE2 . HIS A 1 179 ? -26.347 -14.248 -15.279 1.00 53.77  ? 442  HIS A NE2 1 
ATOM   1232 N  N   . LEU A 1 180 ? -29.124 -9.824  -19.523 1.00 76.57  ? 443  LEU A N   1 
ATOM   1233 C  CA  . LEU A 1 180 ? -29.408 -8.927  -20.696 1.00 69.63  ? 443  LEU A CA  1 
ATOM   1234 C  C   . LEU A 1 180 ? -28.947 -7.499  -20.357 1.00 63.98  ? 443  LEU A C   1 
ATOM   1235 O  O   . LEU A 1 180 ? -28.437 -6.796  -21.252 1.00 67.61  ? 443  LEU A O   1 
ATOM   1236 C  CB  . LEU A 1 180 ? -30.897 -8.981  -21.069 1.00 68.24  ? 443  LEU A CB  1 
ATOM   1237 C  CG  . LEU A 1 180 ? -31.439 -10.340 -21.538 1.00 69.67  ? 443  LEU A CG  1 
ATOM   1238 C  CD1 . LEU A 1 180 ? -32.958 -10.392 -21.446 1.00 75.48  ? 443  LEU A CD1 1 
ATOM   1239 C  CD2 . LEU A 1 180 ? -31.010 -10.670 -22.956 1.00 63.87  ? 443  LEU A CD2 1 
ATOM   1240 N  N   . GLU A 1 181 ? -29.016 -7.133  -19.080 1.00 69.95  ? 444  GLU A N   1 
ATOM   1241 C  CA  . GLU A 1 181 ? -28.531 -5.846  -18.520 1.00 79.59  ? 444  GLU A CA  1 
ATOM   1242 C  C   . GLU A 1 181 ? -27.008 -5.896  -18.288 1.00 76.88  ? 444  GLU A C   1 
ATOM   1243 O  O   . GLU A 1 181 ? -26.440 -4.843  -17.937 1.00 74.03  ? 444  GLU A O   1 
ATOM   1244 C  CB  . GLU A 1 181 ? -29.294 -5.570  -17.218 1.00 89.80  ? 444  GLU A CB  1 
ATOM   1245 C  CG  . GLU A 1 181 ? -29.811 -4.151  -17.053 1.00 93.60  ? 444  GLU A CG  1 
ATOM   1246 C  CD  . GLU A 1 181 ? -30.410 -3.875  -15.678 1.00 97.25  ? 444  GLU A CD  1 
ATOM   1247 O  OE1 . GLU A 1 181 ? -30.244 -2.740  -15.182 1.00 95.50  ? 444  GLU A OE1 1 
ATOM   1248 O  OE2 . GLU A 1 181 ? -31.036 -4.800  -15.093 1.00 91.13  ? 444  GLU A OE2 1 
ATOM   1249 N  N   . GLY A 1 182 ? -26.361 -7.063  -18.436 1.00 73.60  ? 445  GLY A N   1 
ATOM   1250 C  CA  . GLY A 1 182 ? -24.890 -7.209  -18.335 1.00 68.67  ? 445  GLY A CA  1 
ATOM   1251 C  C   . GLY A 1 182 ? -24.376 -7.333  -16.901 1.00 61.23  ? 445  GLY A C   1 
ATOM   1252 O  O   . GLY A 1 182 ? -23.216 -6.993  -16.667 1.00 70.53  ? 445  GLY A O   1 
ATOM   1253 N  N   . LYS A 1 183 ? -25.199 -7.826  -15.977 1.00 55.48  ? 446  LYS A N   1 
ATOM   1254 C  CA  . LYS A 1 183 ? -24.915 -7.955  -14.522 1.00 60.10  ? 446  LYS A CA  1 
ATOM   1255 C  C   . LYS A 1 183 ? -25.339 -9.355  -14.049 1.00 48.54  ? 446  LYS A C   1 
ATOM   1256 O  O   . LYS A 1 183 ? -26.112 -9.992  -14.754 1.00 49.43  ? 446  LYS A O   1 
ATOM   1257 C  CB  . LYS A 1 183 ? -25.718 -6.922  -13.714 1.00 73.00  ? 446  LYS A CB  1 
ATOM   1258 C  CG  . LYS A 1 183 ? -25.677 -5.480  -14.220 1.00 75.78  ? 446  LYS A CG  1 
ATOM   1259 C  CD  . LYS A 1 183 ? -26.992 -4.745  -14.014 1.00 80.45  ? 446  LYS A CD  1 
ATOM   1260 C  CE  . LYS A 1 183 ? -26.977 -3.327  -14.543 1.00 82.76  ? 446  LYS A CE  1 
ATOM   1261 N  NZ  . LYS A 1 183 ? -26.829 -2.340  -13.449 1.00 85.67  ? 446  LYS A NZ  1 
ATOM   1262 N  N   . CYS A 1 184 ? -24.931 -9.786  -12.850 1.00 55.62  ? 447  CYS A N   1 
ATOM   1263 C  CA  . CYS A 1 184 ? -25.175 -11.161 -12.315 1.00 52.59  ? 447  CYS A CA  1 
ATOM   1264 C  C   . CYS A 1 184 ? -25.409 -11.097 -10.794 1.00 54.13  ? 447  CYS A C   1 
ATOM   1265 O  O   . CYS A 1 184 ? -24.670 -10.345 -10.110 1.00 59.52  ? 447  CYS A O   1 
ATOM   1266 C  CB  . CYS A 1 184 ? -23.967 -12.045 -12.680 1.00 56.40  ? 447  CYS A CB  1 
ATOM   1267 S  SG  . CYS A 1 184 ? -24.142 -13.811 -12.288 1.00 49.63  ? 447  CYS A SG  1 
ATOM   1268 N  N   . GLU A 1 185 ? -26.300 -11.933 -10.250 1.00 56.22  ? 448  GLU A N   1 
ATOM   1269 C  CA  . GLU A 1 185 ? -26.600 -11.945 -8.790  1.00 64.24  ? 448  GLU A CA  1 
ATOM   1270 C  C   . GLU A 1 185 ? -26.431 -13.342 -8.180  1.00 66.70  ? 448  GLU A C   1 
ATOM   1271 O  O   . GLU A 1 185 ? -25.939 -13.415 -7.025  1.00 65.57  ? 448  GLU A O   1 
ATOM   1272 C  CB  . GLU A 1 185 ? -28.020 -11.429 -8.548  1.00 77.47  ? 448  GLU A CB  1 
ATOM   1273 C  CG  . GLU A 1 185 ? -28.285 -10.973 -7.124  1.00 79.81  ? 448  GLU A CG  1 
ATOM   1274 C  CD  . GLU A 1 185 ? -29.695 -10.450 -6.904  1.00 85.81  ? 448  GLU A CD  1 
ATOM   1275 O  OE1 . GLU A 1 185 ? -29.829 -9.226  -6.710  1.00 94.01  ? 448  GLU A OE1 1 
ATOM   1276 O  OE2 . GLU A 1 185 ? -30.657 -11.266 -6.937  1.00 84.15  ? 448  GLU A OE2 1 
ATOM   1277 N  N   . THR A 1 186 ? -26.848 -14.403 -8.878  1.00 59.44  ? 449  THR A N   1 
ATOM   1278 C  CA  . THR A 1 186 ? -27.036 -15.743 -8.267  1.00 59.27  ? 449  THR A CA  1 
ATOM   1279 C  C   . THR A 1 186 ? -26.154 -16.818 -8.917  1.00 54.36  ? 449  THR A C   1 
ATOM   1280 O  O   . THR A 1 186 ? -26.199 -17.937 -8.399  1.00 58.90  ? 449  THR A O   1 
ATOM   1281 C  CB  . THR A 1 186 ? -28.512 -16.147 -8.327  1.00 66.25  ? 449  THR A CB  1 
ATOM   1282 O  OG1 . THR A 1 186 ? -28.868 -16.227 -9.705  1.00 68.46  ? 449  THR A OG1 1 
ATOM   1283 C  CG2 . THR A 1 186 ? -29.425 -15.165 -7.633  1.00 71.05  ? 449  THR A CG2 1 
ATOM   1284 N  N   . CYS A 1 187 ? -25.388 -16.518 -9.981  1.00 50.88  ? 450  CYS A N   1 
ATOM   1285 C  CA  . CYS A 1 187 ? -24.522 -17.509 -10.695 1.00 48.68  ? 450  CYS A CA  1 
ATOM   1286 C  C   . CYS A 1 187 ? -23.176 -17.683 -9.938  1.00 50.21  ? 450  CYS A C   1 
ATOM   1287 O  O   . CYS A 1 187 ? -22.132 -17.067 -10.338 1.00 47.18  ? 450  CYS A O   1 
ATOM   1288 C  CB  . CYS A 1 187 ? -24.407 -17.110 -12.164 1.00 49.60  ? 450  CYS A CB  1 
ATOM   1289 S  SG  . CYS A 1 187 ? -26.029 -16.874 -12.974 1.00 49.97  ? 450  CYS A SG  1 
ATOM   1290 N  N   . VAL A 1 188 ? -23.194 -18.500 -8.878  0.50 51.38  ? 451  VAL A N   1 
ATOM   1291 C  CA  . VAL A 1 188 ? -22.042 -18.734 -7.955  0.50 54.84  ? 451  VAL A CA  1 
ATOM   1292 C  C   . VAL A 1 188 ? -21.685 -20.225 -7.934  0.50 53.38  ? 451  VAL A C   1 
ATOM   1293 O  O   . VAL A 1 188 ? -22.595 -21.054 -7.783  0.50 51.38  ? 451  VAL A O   1 
ATOM   1294 C  CB  . VAL A 1 188 ? -22.356 -18.232 -6.533  0.50 57.91  ? 451  VAL A CB  1 
ATOM   1295 C  CG1 . VAL A 1 188 ? -21.341 -18.744 -5.518  0.50 58.99  ? 451  VAL A CG1 1 
ATOM   1296 C  CG2 . VAL A 1 188 ? -22.452 -16.716 -6.486  0.50 59.53  ? 451  VAL A CG2 1 
ATOM   1297 N  N   . TYR A 1 189 ? -20.391 -20.537 -8.028  1.00 54.57  ? 452  TYR A N   1 
ATOM   1298 C  CA  . TYR A 1 189 ? -19.888 -21.935 -8.020  1.00 59.35  ? 452  TYR A CA  1 
ATOM   1299 C  C   . TYR A 1 189 ? -19.770 -22.442 -6.573  1.00 62.94  ? 452  TYR A C   1 
ATOM   1300 O  O   . TYR A 1 189 ? -19.540 -21.647 -5.652  1.00 63.81  ? 452  TYR A O   1 
ATOM   1301 C  CB  . TYR A 1 189 ? -18.601 -22.012 -8.843  1.00 57.04  ? 452  TYR A CB  1 
ATOM   1302 C  CG  . TYR A 1 189 ? -18.844 -21.894 -10.325 1.00 55.61  ? 452  TYR A CG  1 
ATOM   1303 C  CD1 . TYR A 1 189 ? -19.511 -22.894 -11.018 1.00 60.84  ? 452  TYR A CD1 1 
ATOM   1304 C  CD2 . TYR A 1 189 ? -18.462 -20.764 -11.025 1.00 57.52  ? 452  TYR A CD2 1 
ATOM   1305 C  CE1 . TYR A 1 189 ? -19.769 -22.779 -12.374 1.00 64.95  ? 452  TYR A CE1 1 
ATOM   1306 C  CE2 . TYR A 1 189 ? -18.691 -20.644 -12.390 1.00 57.66  ? 452  TYR A CE2 1 
ATOM   1307 C  CZ  . TYR A 1 189 ? -19.354 -21.651 -13.064 1.00 56.61  ? 452  TYR A CZ  1 
ATOM   1308 O  OH  . TYR A 1 189 ? -19.606 -21.526 -14.400 1.00 69.57  ? 452  TYR A OH  1 
ATOM   1309 N  N   . ASN A 1 190 ? -19.979 -23.748 -6.389  0.50 68.50  ? 453  ASN A N   1 
ATOM   1310 C  CA  . ASN A 1 190 ? -19.785 -24.479 -5.108  0.50 72.33  ? 453  ASN A CA  1 
ATOM   1311 C  C   . ASN A 1 190 ? -18.750 -25.588 -5.328  0.50 72.70  ? 453  ASN A C   1 
ATOM   1312 O  O   . ASN A 1 190 ? -19.120 -26.632 -5.897  0.50 68.30  ? 453  ASN A O   1 
ATOM   1313 C  CB  . ASN A 1 190 ? -21.101 -25.056 -4.581  0.50 73.25  ? 453  ASN A CB  1 
ATOM   1314 C  CG  . ASN A 1 190 ? -22.152 -23.997 -4.326  0.50 74.29  ? 453  ASN A CG  1 
ATOM   1315 O  OD1 . ASN A 1 190 ? -22.194 -22.972 -5.003  0.50 80.68  ? 453  ASN A OD1 1 
ATOM   1316 N  ND2 . ASN A 1 190 ? -23.014 -24.241 -3.355  0.50 75.09  ? 453  ASN A ND2 1 
ATOM   1317 N  N   . MET A 1 191 ? -17.500 -25.354 -4.912  0.50 81.12  ? 454  MET A N   1 
ATOM   1318 C  CA  . MET A 1 191 ? -16.380 -26.326 -5.031  0.50 88.32  ? 454  MET A CA  1 
ATOM   1319 C  C   . MET A 1 191 ? -16.722 -27.558 -4.186  0.50 91.41  ? 454  MET A C   1 
ATOM   1320 O  O   . MET A 1 191 ? -17.256 -27.372 -3.073  0.50 90.45  ? 454  MET A O   1 
ATOM   1321 C  CB  . MET A 1 191 ? -15.064 -25.706 -4.553  0.50 92.18  ? 454  MET A CB  1 
ATOM   1322 C  CG  . MET A 1 191 ? -13.830 -26.450 -5.029  0.50 97.52  ? 454  MET A CG  1 
ATOM   1323 S  SD  . MET A 1 191 ? -12.395 -25.362 -5.261  0.50 103.24 ? 454  MET A SD  1 
ATOM   1324 C  CE  . MET A 1 191 ? -12.692 -24.770 -6.927  0.50 104.77 ? 454  MET A CE  1 
ATOM   1325 N  N   . MET A 1 192 ? -16.451 -28.761 -4.708  0.50 94.40  ? 455  MET A N   1 
ATOM   1326 C  CA  . MET A 1 192 ? -16.870 -30.056 -4.100  0.50 95.53  ? 455  MET A CA  1 
ATOM   1327 C  C   . MET A 1 192 ? -16.318 -31.228 -4.925  0.50 96.76  ? 455  MET A C   1 
ATOM   1328 O  O   . MET A 1 192 ? -15.647 -30.958 -5.945  0.50 95.76  ? 455  MET A O   1 
ATOM   1329 C  CB  . MET A 1 192 ? -18.399 -30.149 -4.040  0.50 92.88  ? 455  MET A CB  1 
ATOM   1330 C  CG  . MET A 1 192 ? -18.963 -30.211 -2.629  0.50 90.37  ? 455  MET A CG  1 
ATOM   1331 S  SD  . MET A 1 192 ? -20.679 -29.620 -2.531  0.50 87.49  ? 455  MET A SD  1 
ATOM   1332 C  CE  . MET A 1 192 ? -20.455 -27.859 -2.777  0.50 81.72  ? 455  MET A CE  1 
ATOM   1333 N  N   . ALA A 1 210 ? -11.812 -31.966 -8.923  0.50 91.38  ? 473  ALA A N   1 
ATOM   1334 C  CA  . ALA A 1 210 ? -12.409 -30.689 -8.464  0.50 87.07  ? 473  ALA A CA  1 
ATOM   1335 C  C   . ALA A 1 210 ? -13.609 -30.331 -9.351  0.50 80.34  ? 473  ALA A C   1 
ATOM   1336 O  O   . ALA A 1 210 ? -13.383 -29.857 -10.482 0.50 80.08  ? 473  ALA A O   1 
ATOM   1337 C  CB  . ALA A 1 210 ? -11.361 -29.603 -8.485  0.50 84.80  ? 473  ALA A CB  1 
ATOM   1338 N  N   . ILE A 1 211 ? -14.831 -30.546 -8.845  0.50 73.95  ? 474  ILE A N   1 
ATOM   1339 C  CA  . ILE A 1 211 ? -16.114 -30.293 -9.573  0.50 71.05  ? 474  ILE A CA  1 
ATOM   1340 C  C   . ILE A 1 211 ? -16.843 -29.116 -8.911  0.50 68.38  ? 474  ILE A C   1 
ATOM   1341 O  O   . ILE A 1 211 ? -16.797 -29.005 -7.667  0.50 66.57  ? 474  ILE A O   1 
ATOM   1342 C  CB  . ILE A 1 211 ? -16.995 -31.559 -9.608  0.50 70.88  ? 474  ILE A CB  1 
ATOM   1343 C  CG1 . ILE A 1 211 ? -16.273 -32.742 -10.263 0.50 74.20  ? 474  ILE A CG1 1 
ATOM   1344 C  CG2 . ILE A 1 211 ? -18.329 -31.270 -10.282 0.50 67.95  ? 474  ILE A CG2 1 
ATOM   1345 C  CD1 . ILE A 1 211 ? -15.272 -33.436 -9.364  0.50 74.62  ? 474  ILE A CD1 1 
ATOM   1346 N  N   . TRP A 1 212 ? -17.502 -28.282 -9.719  0.50 63.25  ? 475  TRP A N   1 
ATOM   1347 C  CA  . TRP A 1 212 ? -18.173 -27.030 -9.281  0.50 64.54  ? 475  TRP A CA  1 
ATOM   1348 C  C   . TRP A 1 212 ? -19.666 -27.104 -9.614  0.50 63.51  ? 475  TRP A C   1 
ATOM   1349 O  O   . TRP A 1 212 ? -20.011 -26.877 -10.784 0.50 67.12  ? 475  TRP A O   1 
ATOM   1350 C  CB  . TRP A 1 212 ? -17.513 -25.813 -9.945  0.50 64.60  ? 475  TRP A CB  1 
ATOM   1351 C  CG  . TRP A 1 212 ? -16.016 -25.811 -9.895  0.50 62.92  ? 475  TRP A CG  1 
ATOM   1352 C  CD1 . TRP A 1 212 ? -15.198 -26.873 -9.636  0.50 64.21  ? 475  TRP A CD1 1 
ATOM   1353 C  CD2 . TRP A 1 212 ? -15.148 -24.694 -10.155 0.50 61.09  ? 475  TRP A CD2 1 
ATOM   1354 N  NE1 . TRP A 1 212 ? -13.886 -26.489 -9.695  0.50 63.63  ? 475  TRP A NE1 1 
ATOM   1355 C  CE2 . TRP A 1 212 ? -13.823 -25.158 -10.011 0.50 61.99  ? 475  TRP A CE2 1 
ATOM   1356 C  CE3 . TRP A 1 212 ? -15.359 -23.351 -10.486 0.50 59.94  ? 475  TRP A CE3 1 
ATOM   1357 C  CZ2 . TRP A 1 212 ? -12.720 -24.326 -10.191 0.50 61.83  ? 475  TRP A CZ2 1 
ATOM   1358 C  CZ3 . TRP A 1 212 ? -14.269 -22.530 -10.667 0.50 60.44  ? 475  TRP A CZ3 1 
ATOM   1359 C  CH2 . TRP A 1 212 ? -12.968 -23.014 -10.525 0.50 61.72  ? 475  TRP A CH2 1 
ATOM   1360 N  N   . TYR A 1 213 ? -20.509 -27.410 -8.622  0.50 65.29  ? 476  TYR A N   1 
ATOM   1361 C  CA  . TYR A 1 213 ? -21.993 -27.370 -8.714  0.50 63.22  ? 476  TYR A CA  1 
ATOM   1362 C  C   . TYR A 1 213 ? -22.462 -25.909 -8.743  0.50 60.04  ? 476  TYR A C   1 
ATOM   1363 O  O   . TYR A 1 213 ? -21.662 -25.013 -8.409  0.50 53.51  ? 476  TYR A O   1 
ATOM   1364 C  CB  . TYR A 1 213 ? -22.625 -28.129 -7.542  0.50 69.04  ? 476  TYR A CB  1 
ATOM   1365 C  CG  . TYR A 1 213 ? -22.214 -29.576 -7.432  0.50 73.49  ? 476  TYR A CG  1 
ATOM   1366 C  CD1 . TYR A 1 213 ? -22.993 -30.585 -7.973  0.50 78.13  ? 476  TYR A CD1 1 
ATOM   1367 C  CD2 . TYR A 1 213 ? -21.039 -29.941 -6.795  0.50 77.22  ? 476  TYR A CD2 1 
ATOM   1368 C  CE1 . TYR A 1 213 ? -22.622 -31.917 -7.882  0.50 80.89  ? 476  TYR A CE1 1 
ATOM   1369 C  CE2 . TYR A 1 213 ? -20.653 -31.268 -6.694  0.50 79.70  ? 476  TYR A CE2 1 
ATOM   1370 C  CZ  . TYR A 1 213 ? -21.446 -32.262 -7.239  0.50 81.19  ? 476  TYR A CZ  1 
ATOM   1371 O  OH  . TYR A 1 213 ? -21.071 -33.572 -7.146  0.50 81.82  ? 476  TYR A OH  1 
ATOM   1372 N  N   . MET A 1 214 ? -23.722 -25.684 -9.135  0.50 58.67  ? 477  MET A N   1 
ATOM   1373 C  CA  . MET A 1 214 ? -24.382 -24.350 -9.216  0.50 58.07  ? 477  MET A CA  1 
ATOM   1374 C  C   . MET A 1 214 ? -25.867 -24.511 -8.892  0.50 52.74  ? 477  MET A C   1 
ATOM   1375 O  O   . MET A 1 214 ? -26.344 -25.649 -8.949  0.50 51.35  ? 477  MET A O   1 
ATOM   1376 C  CB  . MET A 1 214 ? -24.275 -23.764 -10.625 0.50 61.58  ? 477  MET A CB  1 
ATOM   1377 C  CG  . MET A 1 214 ? -23.230 -22.685 -10.779 0.50 64.35  ? 477  MET A CG  1 
ATOM   1378 S  SD  . MET A 1 214 ? -23.136 -22.136 -12.502 0.50 67.14  ? 477  MET A SD  1 
ATOM   1379 C  CE  . MET A 1 214 ? -22.491 -20.479 -12.271 0.50 63.74  ? 477  MET A CE  1 
ATOM   1380 N  N   . TRP A 1 215 ? -26.574 -23.412 -8.607  0.50 52.45  ? 478  TRP A N   1 
ATOM   1381 C  CA  . TRP A 1 215 ? -28.058 -23.418 -8.493  0.50 54.31  ? 478  TRP A CA  1 
ATOM   1382 C  C   . TRP A 1 215 ? -28.657 -23.646 -9.891  0.50 53.85  ? 478  TRP A C   1 
ATOM   1383 O  O   . TRP A 1 215 ? -28.147 -23.054 -10.865 0.50 54.69  ? 478  TRP A O   1 
ATOM   1384 C  CB  . TRP A 1 215 ? -28.575 -22.152 -7.796  0.50 54.21  ? 478  TRP A CB  1 
ATOM   1385 C  CG  . TRP A 1 215 ? -28.982 -21.014 -8.682  0.50 56.90  ? 478  TRP A CG  1 
ATOM   1386 C  CD1 . TRP A 1 215 ? -28.163 -20.131 -9.326  0.50 59.12  ? 478  TRP A CD1 1 
ATOM   1387 C  CD2 . TRP A 1 215 ? -30.327 -20.583 -8.961  0.50 57.29  ? 478  TRP A CD2 1 
ATOM   1388 N  NE1 . TRP A 1 215 ? -28.901 -19.204 -10.015 0.50 58.39  ? 478  TRP A NE1 1 
ATOM   1389 C  CE2 . TRP A 1 215 ? -30.232 -19.453 -9.805  0.50 58.98  ? 478  TRP A CE2 1 
ATOM   1390 C  CE3 . TRP A 1 215 ? -31.595 -21.049 -8.597  0.50 55.50  ? 478  TRP A CE3 1 
ATOM   1391 C  CZ2 . TRP A 1 215 ? -31.359 -18.786 -10.285 0.50 57.16  ? 478  TRP A CZ2 1 
ATOM   1392 C  CZ3 . TRP A 1 215 ? -32.706 -20.390 -9.074  0.50 57.15  ? 478  TRP A CZ3 1 
ATOM   1393 C  CH2 . TRP A 1 215 ? -32.588 -19.276 -9.906  0.50 57.09  ? 478  TRP A CH2 1 
ATOM   1394 N  N   . LEU A 1 216 ? -29.645 -24.538 -9.991  0.50 51.55  ? 479  LEU A N   1 
ATOM   1395 C  CA  . LEU A 1 216 ? -30.223 -25.007 -11.277 0.50 52.78  ? 479  LEU A CA  1 
ATOM   1396 C  C   . LEU A 1 216 ? -30.463 -23.803 -12.197 0.50 53.41  ? 479  LEU A C   1 
ATOM   1397 O  O   . LEU A 1 216 ? -30.234 -23.934 -13.414 0.50 53.93  ? 479  LEU A O   1 
ATOM   1398 C  CB  . LEU A 1 216 ? -31.524 -25.764 -10.993 0.50 54.67  ? 479  LEU A CB  1 
ATOM   1399 C  CG  . LEU A 1 216 ? -31.980 -26.717 -12.094 0.50 56.95  ? 479  LEU A CG  1 
ATOM   1400 C  CD1 . LEU A 1 216 ? -30.973 -27.842 -12.285 0.50 56.55  ? 479  LEU A CD1 1 
ATOM   1401 C  CD2 . LEU A 1 216 ? -33.361 -27.282 -11.789 0.50 58.69  ? 479  LEU A CD2 1 
ATOM   1402 N  N   . GLY A 1 217 ? -30.896 -22.675 -11.625 0.50 50.56  ? 480  GLY A N   1 
ATOM   1403 C  CA  . GLY A 1 217 ? -31.171 -21.422 -12.353 0.50 50.07  ? 480  GLY A CA  1 
ATOM   1404 C  C   . GLY A 1 217 ? -29.977 -20.984 -13.182 0.50 46.98  ? 480  GLY A C   1 
ATOM   1405 O  O   . GLY A 1 217 ? -30.176 -20.578 -14.339 0.50 42.84  ? 480  GLY A O   1 
ATOM   1406 N  N   . ALA A 1 218 ? -28.773 -21.064 -12.608 0.50 47.77  ? 481  ALA A N   1 
ATOM   1407 C  CA  . ALA A 1 218 ? -27.491 -20.765 -13.291 0.50 45.66  ? 481  ALA A CA  1 
ATOM   1408 C  C   . ALA A 1 218 ? -27.230 -21.821 -14.371 0.50 45.74  ? 481  ALA A C   1 
ATOM   1409 O  O   . ALA A 1 218 ? -26.793 -21.435 -15.469 0.50 45.35  ? 481  ALA A O   1 
ATOM   1410 C  CB  . ALA A 1 218 ? -26.370 -20.715 -12.286 0.50 44.00  ? 481  ALA A CB  1 
ATOM   1411 N  N   . ARG A 1 219 ? -27.494 -23.097 -14.061 0.50 46.73  ? 482  ARG A N   1 
ATOM   1412 C  CA  . ARG A 1 219 ? -27.322 -24.254 -14.986 0.50 49.52  ? 482  ARG A CA  1 
ATOM   1413 C  C   . ARG A 1 219 ? -28.243 -24.085 -16.196 0.50 49.18  ? 482  ARG A C   1 
ATOM   1414 O  O   . ARG A 1 219 ? -27.766 -24.280 -17.339 0.50 42.59  ? 482  ARG A O   1 
ATOM   1415 C  CB  . ARG A 1 219 ? -27.647 -25.578 -14.295 0.50 50.83  ? 482  ARG A CB  1 
ATOM   1416 C  CG  . ARG A 1 219 ? -26.418 -26.370 -13.886 0.50 59.06  ? 482  ARG A CG  1 
ATOM   1417 C  CD  . ARG A 1 219 ? -25.425 -25.482 -13.162 0.50 62.61  ? 482  ARG A CD  1 
ATOM   1418 N  NE  . ARG A 1 219 ? -24.344 -24.994 -14.008 0.50 65.23  ? 482  ARG A NE  1 
ATOM   1419 C  CZ  . ARG A 1 219 ? -23.098 -25.447 -13.958 0.50 66.25  ? 482  ARG A CZ  1 
ATOM   1420 N  NH1 . ARG A 1 219 ? -22.169 -24.936 -14.748 0.50 68.67  ? 482  ARG A NH1 1 
ATOM   1421 N  NH2 . ARG A 1 219 ? -22.786 -26.408 -13.105 0.50 67.34  ? 482  ARG A NH2 1 
ATOM   1422 N  N   . PHE A 1 220 ? -29.509 -23.730 -15.947 1.00 49.98  ? 483  PHE A N   1 
ATOM   1423 C  CA  . PHE A 1 220 ? -30.499 -23.513 -17.022 1.00 47.27  ? 483  PHE A CA  1 
ATOM   1424 C  C   . PHE A 1 220 ? -29.979 -22.450 -17.981 1.00 44.26  ? 483  PHE A C   1 
ATOM   1425 O  O   . PHE A 1 220 ? -29.954 -22.707 -19.197 1.00 49.08  ? 483  PHE A O   1 
ATOM   1426 C  CB  . PHE A 1 220 ? -31.877 -23.070 -16.530 1.00 46.79  ? 483  PHE A CB  1 
ATOM   1427 C  CG  . PHE A 1 220 ? -32.742 -22.753 -17.716 1.00 37.17  ? 483  PHE A CG  1 
ATOM   1428 C  CD1 . PHE A 1 220 ? -33.130 -23.764 -18.575 1.00 43.33  ? 483  PHE A CD1 1 
ATOM   1429 C  CD2 . PHE A 1 220 ? -33.036 -21.451 -18.043 1.00 39.08  ? 483  PHE A CD2 1 
ATOM   1430 C  CE1 . PHE A 1 220 ? -33.877 -23.486 -19.705 1.00 48.59  ? 483  PHE A CE1 1 
ATOM   1431 C  CE2 . PHE A 1 220 ? -33.782 -21.165 -19.178 1.00 43.87  ? 483  PHE A CE2 1 
ATOM   1432 C  CZ  . PHE A 1 220 ? -34.199 -22.184 -20.004 1.00 45.81  ? 483  PHE A CZ  1 
ATOM   1433 N  N   . LEU A 1 221 ? -29.644 -21.291 -17.438 1.00 42.48  ? 484  LEU A N   1 
ATOM   1434 C  CA  . LEU A 1 221 ? -29.118 -20.139 -18.203 1.00 47.70  ? 484  LEU A CA  1 
ATOM   1435 C  C   . LEU A 1 221 ? -27.854 -20.543 -18.969 1.00 49.60  ? 484  LEU A C   1 
ATOM   1436 O  O   . LEU A 1 221 ? -27.696 -20.101 -20.155 1.00 42.43  ? 484  LEU A O   1 
ATOM   1437 C  CB  . LEU A 1 221 ? -28.874 -18.979 -17.241 1.00 47.63  ? 484  LEU A CB  1 
ATOM   1438 C  CG  . LEU A 1 221 ? -30.149 -18.272 -16.769 1.00 52.35  ? 484  LEU A CG  1 
ATOM   1439 C  CD1 . LEU A 1 221 ? -29.812 -17.153 -15.802 1.00 59.63  ? 484  LEU A CD1 1 
ATOM   1440 C  CD2 . LEU A 1 221 ? -30.935 -17.707 -17.940 1.00 55.50  ? 484  LEU A CD2 1 
ATOM   1441 N  N   . GLU A 1 222 ? -26.979 -21.350 -18.358 1.00 43.48  ? 485  GLU A N   1 
ATOM   1442 C  CA  . GLU A 1 222 ? -25.797 -21.848 -19.106 1.00 43.02  ? 485  GLU A CA  1 
ATOM   1443 C  C   . GLU A 1 222 ? -26.321 -22.728 -20.273 1.00 40.22  ? 485  GLU A C   1 
ATOM   1444 O  O   . GLU A 1 222 ? -25.868 -22.515 -21.397 1.00 35.98  ? 485  GLU A O   1 
ATOM   1445 C  CB  . GLU A 1 222 ? -24.792 -22.518 -18.156 1.00 43.37  ? 485  GLU A CB  1 
ATOM   1446 C  CG  . GLU A 1 222 ? -23.675 -23.231 -18.893 1.00 45.36  ? 485  GLU A CG  1 
ATOM   1447 C  CD  . GLU A 1 222 ? -22.751 -24.045 -18.012 1.00 48.34  ? 485  GLU A CD  1 
ATOM   1448 O  OE1 . GLU A 1 222 ? -21.549 -23.704 -17.927 1.00 46.49  ? 485  GLU A OE1 1 
ATOM   1449 O  OE2 . GLU A 1 222 ? -23.235 -25.004 -17.412 1.00 46.13  ? 485  GLU A OE2 1 
ATOM   1450 N  N   . PHE A 1 223 ? -27.296 -23.619 -20.046 1.00 38.16  ? 486  PHE A N   1 
ATOM   1451 C  CA  . PHE A 1 223 ? -27.799 -24.607 -21.043 1.00 42.17  ? 486  PHE A CA  1 
ATOM   1452 C  C   . PHE A 1 223 ? -28.580 -23.895 -22.135 1.00 44.90  ? 486  PHE A C   1 
ATOM   1453 O  O   . PHE A 1 223 ? -28.395 -24.253 -23.305 1.00 40.88  ? 486  PHE A O   1 
ATOM   1454 C  CB  . PHE A 1 223 ? -28.633 -25.694 -20.382 1.00 45.10  ? 486  PHE A CB  1 
ATOM   1455 C  CG  . PHE A 1 223 ? -29.398 -26.597 -21.313 1.00 45.43  ? 486  PHE A CG  1 
ATOM   1456 C  CD1 . PHE A 1 223 ? -28.786 -27.687 -21.911 1.00 44.65  ? 486  PHE A CD1 1 
ATOM   1457 C  CD2 . PHE A 1 223 ? -30.744 -26.372 -21.559 1.00 45.72  ? 486  PHE A CD2 1 
ATOM   1458 C  CE1 . PHE A 1 223 ? -29.504 -28.533 -22.747 1.00 49.55  ? 486  PHE A CE1 1 
ATOM   1459 C  CE2 . PHE A 1 223 ? -31.465 -27.220 -22.384 1.00 44.48  ? 486  PHE A CE2 1 
ATOM   1460 C  CZ  . PHE A 1 223 ? -30.848 -28.308 -22.969 1.00 50.34  ? 486  PHE A CZ  1 
ATOM   1461 N  N   . GLU A 1 224 ? -29.308 -22.837 -21.783 1.00 50.46  ? 487  GLU A N   1 
ATOM   1462 C  CA  . GLU A 1 224 ? -30.083 -22.040 -22.760 1.00 49.45  ? 487  GLU A CA  1 
ATOM   1463 C  C   . GLU A 1 224 ? -29.108 -21.430 -23.779 1.00 48.96  ? 487  GLU A C   1 
ATOM   1464 O  O   . GLU A 1 224 ? -29.442 -21.357 -25.010 1.00 43.78  ? 487  GLU A O   1 
ATOM   1465 C  CB  . GLU A 1 224 ? -30.911 -20.980 -22.027 1.00 54.58  ? 487  GLU A CB  1 
ATOM   1466 C  CG  . GLU A 1 224 ? -31.511 -19.907 -22.932 1.00 59.53  ? 487  GLU A CG  1 
ATOM   1467 C  CD  . GLU A 1 224 ? -32.570 -19.017 -22.283 1.00 63.03  ? 487  GLU A CD  1 
ATOM   1468 O  OE1 . GLU A 1 224 ? -33.783 -19.270 -22.527 1.00 58.00  ? 487  GLU A OE1 1 
ATOM   1469 O  OE2 . GLU A 1 224 ? -32.183 -18.060 -21.572 1.00 54.32  ? 487  GLU A OE2 1 
ATOM   1470 N  N   . ALA A 1 225 ? -27.950 -20.971 -23.320 1.00 39.37  ? 488  ALA A N   1 
ATOM   1471 C  CA  . ALA A 1 225 ? -27.049 -20.173 -24.172 1.00 39.93  ? 488  ALA A CA  1 
ATOM   1472 C  C   . ALA A 1 225 ? -26.059 -21.057 -24.931 1.00 40.10  ? 488  ALA A C   1 
ATOM   1473 O  O   . ALA A 1 225 ? -25.682 -20.613 -26.047 1.00 40.74  ? 488  ALA A O   1 
ATOM   1474 C  CB  . ALA A 1 225 ? -26.335 -19.135 -23.371 1.00 42.44  ? 488  ALA A CB  1 
ATOM   1475 N  N   . LEU A 1 226 ? -25.650 -22.214 -24.381 1.00 38.59  ? 489  LEU A N   1 
ATOM   1476 C  CA  . LEU A 1 226 ? -24.449 -22.961 -24.882 1.00 35.11  ? 489  LEU A CA  1 
ATOM   1477 C  C   . LEU A 1 226 ? -24.738 -24.453 -25.031 1.00 36.77  ? 489  LEU A C   1 
ATOM   1478 O  O   . LEU A 1 226 ? -23.853 -25.197 -25.570 1.00 36.21  ? 489  LEU A O   1 
ATOM   1479 C  CB  . LEU A 1 226 ? -23.256 -22.703 -23.956 1.00 33.38  ? 489  LEU A CB  1 
ATOM   1480 C  CG  . LEU A 1 226 ? -22.762 -21.260 -23.915 1.00 35.89  ? 489  LEU A CG  1 
ATOM   1481 C  CD1 . LEU A 1 226 ? -21.563 -21.064 -22.991 1.00 42.07  ? 489  LEU A CD1 1 
ATOM   1482 C  CD2 . LEU A 1 226 ? -22.377 -20.786 -25.307 1.00 42.81  ? 489  LEU A CD2 1 
ATOM   1483 N  N   . GLY A 1 227 ? -25.949 -24.890 -24.679 1.00 31.22  ? 490  GLY A N   1 
ATOM   1484 C  CA  . GLY A 1 227 ? -26.357 -26.304 -24.783 1.00 32.59  ? 490  GLY A CA  1 
ATOM   1485 C  C   . GLY A 1 227 ? -26.348 -26.785 -26.203 1.00 28.55  ? 490  GLY A C   1 
ATOM   1486 O  O   . GLY A 1 227 ? -26.160 -28.016 -26.447 1.00 31.24  ? 490  GLY A O   1 
ATOM   1487 N  N   . PHE A 1 228 ? -26.548 -25.875 -27.140 1.00 31.42  ? 491  PHE A N   1 
ATOM   1488 C  CA  . PHE A 1 228 ? -26.558 -26.232 -28.582 1.00 33.41  ? 491  PHE A CA  1 
ATOM   1489 C  C   . PHE A 1 228 ? -25.272 -26.981 -28.941 1.00 29.15  ? 491  PHE A C   1 
ATOM   1490 O  O   . PHE A 1 228 ? -25.361 -27.808 -29.857 1.00 31.13  ? 491  PHE A O   1 
ATOM   1491 C  CB  . PHE A 1 228 ? -26.768 -25.037 -29.512 1.00 32.65  ? 491  PHE A CB  1 
ATOM   1492 C  CG  . PHE A 1 228 ? -25.621 -24.077 -29.633 1.00 29.12  ? 491  PHE A CG  1 
ATOM   1493 C  CD1 . PHE A 1 228 ? -25.459 -23.062 -28.709 1.00 33.66  ? 491  PHE A CD1 1 
ATOM   1494 C  CD2 . PHE A 1 228 ? -24.669 -24.219 -30.617 1.00 33.58  ? 491  PHE A CD2 1 
ATOM   1495 C  CE1 . PHE A 1 228 ? -24.400 -22.179 -28.786 1.00 32.19  ? 491  PHE A CE1 1 
ATOM   1496 C  CE2 . PHE A 1 228 ? -23.604 -23.330 -30.699 1.00 30.93  ? 491  PHE A CE2 1 
ATOM   1497 C  CZ  . PHE A 1 228 ? -23.459 -22.322 -29.775 1.00 33.01  ? 491  PHE A CZ  1 
ATOM   1498 N  N   . LEU A 1 229 ? -24.131 -26.663 -28.324 1.00 31.30  ? 492  LEU A N   1 
ATOM   1499 C  CA  . LEU A 1 229 ? -22.828 -27.295 -28.710 1.00 32.14  ? 492  LEU A CA  1 
ATOM   1500 C  C   . LEU A 1 229 ? -22.927 -28.816 -28.557 1.00 28.64  ? 492  LEU A C   1 
ATOM   1501 O  O   . LEU A 1 229 ? -22.559 -29.557 -29.478 1.00 32.25  ? 492  LEU A O   1 
ATOM   1502 C  CB  . LEU A 1 229 ? -21.703 -26.697 -27.858 1.00 32.03  ? 492  LEU A CB  1 
ATOM   1503 C  CG  . LEU A 1 229 ? -21.286 -25.283 -28.243 1.00 33.47  ? 492  LEU A CG  1 
ATOM   1504 C  CD1 . LEU A 1 229 ? -20.303 -24.765 -27.239 1.00 35.82  ? 492  LEU A CD1 1 
ATOM   1505 C  CD2 . LEU A 1 229 ? -20.705 -25.194 -29.664 1.00 34.27  ? 492  LEU A CD2 1 
ATOM   1506 N  N   . ASN A 1 230 ? -23.533 -29.271 -27.477 1.00 28.53  ? 493  ASN A N   1 
ATOM   1507 C  CA  . ASN A 1 230 ? -23.783 -30.713 -27.251 1.00 28.20  ? 493  ASN A CA  1 
ATOM   1508 C  C   . ASN A 1 230 ? -25.101 -31.172 -27.880 1.00 32.82  ? 493  ASN A C   1 
ATOM   1509 O  O   . ASN A 1 230 ? -25.106 -32.235 -28.546 1.00 30.80  ? 493  ASN A O   1 
ATOM   1510 C  CB  . ASN A 1 230 ? -23.798 -31.011 -25.760 1.00 33.67  ? 493  ASN A CB  1 
ATOM   1511 C  CG  . ASN A 1 230 ? -23.870 -32.495 -25.502 1.00 38.34  ? 493  ASN A CG  1 
ATOM   1512 O  OD1 . ASN A 1 230 ? -24.883 -33.015 -25.032 1.00 42.90  ? 493  ASN A OD1 1 
ATOM   1513 N  ND2 . ASN A 1 230 ? -22.805 -33.184 -25.848 1.00 37.41  ? 493  ASN A ND2 1 
ATOM   1514 N  N   . GLU A 1 231 ? -26.198 -30.441 -27.697 1.00 34.51  ? 494  GLU A N   1 
ATOM   1515 C  CA  . GLU A 1 231 ? -27.532 -30.916 -28.177 1.00 32.98  ? 494  GLU A CA  1 
ATOM   1516 C  C   . GLU A 1 231 ? -27.523 -31.119 -29.699 1.00 31.84  ? 494  GLU A C   1 
ATOM   1517 O  O   . GLU A 1 231 ? -28.209 -32.035 -30.157 1.00 30.38  ? 494  GLU A O   1 
ATOM   1518 C  CB  . GLU A 1 231 ? -28.614 -29.891 -27.802 1.00 38.93  ? 494  GLU A CB  1 
ATOM   1519 C  CG  . GLU A 1 231 ? -28.993 -29.854 -26.332 1.00 39.23  ? 494  GLU A CG  1 
ATOM   1520 C  CD  . GLU A 1 231 ? -29.481 -31.171 -25.751 1.00 47.94  ? 494  GLU A CD  1 
ATOM   1521 O  OE1 . GLU A 1 231 ? -30.374 -31.789 -26.352 1.00 48.66  ? 494  GLU A OE1 1 
ATOM   1522 O  OE2 . GLU A 1 231 ? -28.923 -31.599 -24.715 1.00 56.39  ? 494  GLU A OE2 1 
ATOM   1523 N  N   . ASP A 1 232 ? -26.767 -30.301 -30.451 1.00 31.79  ? 495  ASP A N   1 
ATOM   1524 C  CA  . ASP A 1 232 ? -26.729 -30.310 -31.929 1.00 28.66  ? 495  ASP A CA  1 
ATOM   1525 C  C   . ASP A 1 232 ? -25.373 -30.843 -32.436 1.00 33.76  ? 495  ASP A C   1 
ATOM   1526 O  O   . ASP A 1 232 ? -25.103 -30.777 -33.661 1.00 30.49  ? 495  ASP A O   1 
ATOM   1527 C  CB  . ASP A 1 232 ? -27.012 -28.906 -32.461 1.00 35.09  ? 495  ASP A CB  1 
ATOM   1528 C  CG  . ASP A 1 232 ? -28.394 -28.376 -32.088 1.00 33.44  ? 495  ASP A CG  1 
ATOM   1529 O  OD1 . ASP A 1 232 ? -29.224 -29.195 -31.724 1.00 38.53  ? 495  ASP A OD1 1 
ATOM   1530 O  OD2 . ASP A 1 232 ? -28.563 -27.140 -32.093 1.00 31.64  ? 495  ASP A OD2 1 
ATOM   1531 N  N   . HIS A 1 233 ? -24.586 -31.468 -31.563 1.00 35.13  ? 496  HIS A N   1 
ATOM   1532 C  CA  . HIS A 1 233 ? -23.474 -32.376 -31.962 1.00 32.40  ? 496  HIS A CA  1 
ATOM   1533 C  C   . HIS A 1 233 ? -22.416 -31.612 -32.772 1.00 26.39  ? 496  HIS A C   1 
ATOM   1534 O  O   . HIS A 1 233 ? -21.973 -32.101 -33.834 1.00 30.82  ? 496  HIS A O   1 
ATOM   1535 C  CB  . HIS A 1 233 ? -24.030 -33.578 -32.733 1.00 34.63  ? 496  HIS A CB  1 
ATOM   1536 C  CG  . HIS A 1 233 ? -25.146 -34.292 -32.064 1.00 38.92  ? 496  HIS A CG  1 
ATOM   1537 N  ND1 . HIS A 1 233 ? -25.014 -34.882 -30.833 1.00 46.38  ? 496  HIS A ND1 1 
ATOM   1538 C  CD2 . HIS A 1 233 ? -26.450 -34.435 -32.436 1.00 43.61  ? 496  HIS A CD2 1 
ATOM   1539 C  CE1 . HIS A 1 233 ? -26.178 -35.416 -30.480 1.00 47.76  ? 496  HIS A CE1 1 
ATOM   1540 N  NE2 . HIS A 1 233 ? -27.062 -35.177 -31.473 1.00 45.21  ? 496  HIS A NE2 1 
ATOM   1541 N  N   . TRP A 1 234 ? -22.010 -30.456 -32.285 1.00 24.75  ? 497  TRP A N   1 
ATOM   1542 C  CA  . TRP A 1 234 ? -20.950 -29.627 -32.926 1.00 26.29  ? 497  TRP A CA  1 
ATOM   1543 C  C   . TRP A 1 234 ? -19.602 -30.395 -32.974 1.00 27.37  ? 497  TRP A C   1 
ATOM   1544 O  O   . TRP A 1 234 ? -18.792 -30.194 -33.962 1.00 25.21  ? 497  TRP A O   1 
ATOM   1545 C  CB  . TRP A 1 234 ? -20.812 -28.279 -32.197 1.00 26.63  ? 497  TRP A CB  1 
ATOM   1546 C  CG  . TRP A 1 234 ? -21.821 -27.287 -32.696 1.00 31.42  ? 497  TRP A CG  1 
ATOM   1547 C  CD1 . TRP A 1 234 ? -23.177 -27.493 -32.770 1.00 29.82  ? 497  TRP A CD1 1 
ATOM   1548 C  CD2 . TRP A 1 234 ? -21.576 -25.978 -33.255 1.00 29.90  ? 497  TRP A CD2 1 
ATOM   1549 N  NE1 . TRP A 1 234 ? -23.780 -26.400 -33.336 1.00 31.44  ? 497  TRP A NE1 1 
ATOM   1550 C  CE2 . TRP A 1 234 ? -22.846 -25.443 -33.604 1.00 30.49  ? 497  TRP A CE2 1 
ATOM   1551 C  CE3 . TRP A 1 234 ? -20.433 -25.199 -33.493 1.00 29.24  ? 497  TRP A CE3 1 
ATOM   1552 C  CZ2 . TRP A 1 234 ? -23.000 -24.183 -34.179 1.00 31.19  ? 497  TRP A CZ2 1 
ATOM   1553 C  CZ3 . TRP A 1 234 ? -20.589 -23.957 -34.085 1.00 33.60  ? 497  TRP A CZ3 1 
ATOM   1554 C  CH2 . TRP A 1 234 ? -21.858 -23.466 -34.440 1.00 30.16  ? 497  TRP A CH2 1 
ATOM   1555 N  N   . PHE A 1 235 ? -19.372 -31.280 -32.009 1.00 26.64  ? 498  PHE A N   1 
ATOM   1556 C  CA  . PHE A 1 235 ? -18.125 -32.082 -31.899 1.00 26.17  ? 498  PHE A CA  1 
ATOM   1557 C  C   . PHE A 1 235 ? -18.270 -33.537 -32.344 1.00 29.80  ? 498  PHE A C   1 
ATOM   1558 O  O   . PHE A 1 235 ? -17.350 -34.356 -32.003 1.00 27.86  ? 498  PHE A O   1 
ATOM   1559 C  CB  . PHE A 1 235 ? -17.546 -31.878 -30.498 1.00 25.33  ? 498  PHE A CB  1 
ATOM   1560 C  CG  . PHE A 1 235 ? -17.195 -30.445 -30.233 1.00 27.59  ? 498  PHE A CG  1 
ATOM   1561 C  CD1 . PHE A 1 235 ? -16.150 -29.857 -30.927 1.00 28.89  ? 498  PHE A CD1 1 
ATOM   1562 C  CD2 . PHE A 1 235 ? -18.002 -29.639 -29.443 1.00 28.68  ? 498  PHE A CD2 1 
ATOM   1563 C  CE1 . PHE A 1 235 ? -15.856 -28.516 -30.773 1.00 30.12  ? 498  PHE A CE1 1 
ATOM   1564 C  CE2 . PHE A 1 235 ? -17.708 -28.281 -29.302 1.00 31.11  ? 498  PHE A CE2 1 
ATOM   1565 C  CZ  . PHE A 1 235 ? -16.652 -27.719 -29.978 1.00 30.56  ? 498  PHE A CZ  1 
ATOM   1566 N  N   . SER A 1 236 ? -19.338 -33.872 -33.077 0.50 27.81  ? 499  SER A N   1 
ATOM   1567 C  CA  . SER A 1 236 ? -19.444 -35.120 -33.880 0.50 27.83  ? 499  SER A CA  1 
ATOM   1568 C  C   . SER A 1 236 ? -18.205 -35.250 -34.771 0.50 27.05  ? 499  SER A C   1 
ATOM   1569 O  O   . SER A 1 236 ? -17.653 -34.205 -35.141 0.50 26.58  ? 499  SER A O   1 
ATOM   1570 C  CB  . SER A 1 236 ? -20.681 -35.082 -34.725 0.50 28.58  ? 499  SER A CB  1 
ATOM   1571 O  OG  . SER A 1 236 ? -20.675 -33.918 -35.548 0.50 27.35  ? 499  SER A OG  1 
ATOM   1572 N  N   . ARG A 1 237 ? -17.809 -36.456 -35.165 1.00 25.91  ? 500  ARG A N   1 
ATOM   1573 C  CA  . ARG A 1 237 ? -16.665 -36.583 -36.108 1.00 26.90  ? 500  ARG A CA  1 
ATOM   1574 C  C   . ARG A 1 237 ? -17.042 -36.004 -37.481 1.00 32.36  ? 500  ARG A C   1 
ATOM   1575 O  O   . ARG A 1 237 ? -16.204 -35.339 -38.081 1.00 27.42  ? 500  ARG A O   1 
ATOM   1576 C  CB  . ARG A 1 237 ? -16.180 -38.033 -36.209 1.00 29.45  ? 500  ARG A CB  1 
ATOM   1577 C  CG  . ARG A 1 237 ? -14.801 -38.181 -36.829 1.00 27.68  ? 500  ARG A CG  1 
ATOM   1578 C  CD  . ARG A 1 237 ? -14.101 -39.447 -36.385 1.00 27.23  ? 500  ARG A CD  1 
ATOM   1579 N  NE  . ARG A 1 237 ? -12.716 -39.427 -36.814 1.00 24.71  ? 500  ARG A NE  1 
ATOM   1580 C  CZ  . ARG A 1 237 ? -11.738 -38.814 -36.162 1.00 25.27  ? 500  ARG A CZ  1 
ATOM   1581 N  NH1 . ARG A 1 237 ? -11.992 -38.165 -35.041 1.00 24.47  ? 500  ARG A NH1 1 
ATOM   1582 N  NH2 . ARG A 1 237 ? -10.508 -38.850 -36.639 1.00 27.26  ? 500  ARG A NH2 1 
ATOM   1583 N  N   . GLU A 1 238 ? -18.282 -36.223 -37.919 1.00 30.66  ? 501  GLU A N   1 
ATOM   1584 C  CA  . GLU A 1 238 ? -18.748 -35.703 -39.231 1.00 33.17  ? 501  GLU A CA  1 
ATOM   1585 C  C   . GLU A 1 238 ? -18.593 -34.181 -39.275 1.00 28.97  ? 501  GLU A C   1 
ATOM   1586 O  O   . GLU A 1 238 ? -18.157 -33.680 -40.301 1.00 30.91  ? 501  GLU A O   1 
ATOM   1587 C  CB  . GLU A 1 238 ? -20.189 -36.153 -39.495 1.00 38.55  ? 501  GLU A CB  1 
ATOM   1588 C  CG  . GLU A 1 238 ? -20.828 -35.510 -40.709 1.00 44.76  ? 501  GLU A CG  1 
ATOM   1589 C  CD  . GLU A 1 238 ? -22.244 -35.980 -40.995 1.00 57.34  ? 501  GLU A CD  1 
ATOM   1590 O  OE1 . GLU A 1 238 ? -22.961 -35.274 -41.718 1.00 71.65  ? 501  GLU A OE1 1 
ATOM   1591 O  OE2 . GLU A 1 238 ? -22.624 -37.055 -40.497 1.00 68.05  ? 501  GLU A OE2 1 
ATOM   1592 N  N   . ASN A 1 239 ? -18.901 -33.490 -38.181 1.00 30.91  ? 502  ASN A N   1 
ATOM   1593 C  CA  . ASN A 1 239 ? -18.886 -32.004 -38.204 1.00 31.75  ? 502  ASN A CA  1 
ATOM   1594 C  C   . ASN A 1 239 ? -17.519 -31.408 -37.842 1.00 32.81  ? 502  ASN A C   1 
ATOM   1595 O  O   . ASN A 1 239 ? -17.199 -30.378 -38.421 1.00 27.79  ? 502  ASN A O   1 
ATOM   1596 C  CB  . ASN A 1 239 ? -19.945 -31.406 -37.274 1.00 32.53  ? 502  ASN A CB  1 
ATOM   1597 C  CG  . ASN A 1 239 ? -20.162 -29.932 -37.532 1.00 34.51  ? 502  ASN A CG  1 
ATOM   1598 O  OD1 . ASN A 1 239 ? -20.602 -29.552 -38.612 1.00 34.78  ? 502  ASN A OD1 1 
ATOM   1599 N  ND2 . ASN A 1 239 ? -19.845 -29.099 -36.558 1.00 30.84  ? 502  ASN A ND2 1 
ATOM   1600 N  N   . SER A 1 240 ? -16.778 -32.017 -36.909 1.00 27.52  ? 503  SER A N   1 
ATOM   1601 C  CA  . SER A 1 240 ? -15.499 -31.444 -36.395 1.00 26.81  ? 503  SER A CA  1 
ATOM   1602 C  C   . SER A 1 240 ? -14.254 -32.151 -36.955 1.00 23.79  ? 503  SER A C   1 
ATOM   1603 O  O   . SER A 1 240 ? -13.181 -31.580 -36.795 1.00 27.27  ? 503  SER A O   1 
ATOM   1604 C  CB  . SER A 1 240 ? -15.501 -31.505 -34.893 1.00 28.24  ? 503  SER A CB  1 
ATOM   1605 O  OG  . SER A 1 240 ? -15.492 -32.847 -34.441 1.00 28.30  ? 503  SER A OG  1 
ATOM   1606 N  N   . LEU A 1 241 ? -14.397 -33.357 -37.509 1.00 26.88  ? 504  LEU A N   1 
ATOM   1607 C  CA  . LEU A 1 241 ? -13.285 -34.147 -38.121 1.00 30.19  ? 504  LEU A CA  1 
ATOM   1608 C  C   . LEU A 1 241 ? -12.351 -34.767 -37.060 1.00 28.99  ? 504  LEU A C   1 
ATOM   1609 O  O   . LEU A 1 241 ? -11.942 -35.910 -37.256 1.00 29.82  ? 504  LEU A O   1 
ATOM   1610 C  CB  . LEU A 1 241 ? -12.527 -33.269 -39.122 1.00 32.22  ? 504  LEU A CB  1 
ATOM   1611 C  CG  . LEU A 1 241 ? -13.362 -32.673 -40.253 1.00 40.00  ? 504  LEU A CG  1 
ATOM   1612 C  CD1 . LEU A 1 241 ? -12.478 -31.938 -41.246 1.00 40.16  ? 504  LEU A CD1 1 
ATOM   1613 C  CD2 . LEU A 1 241 ? -14.164 -33.750 -40.961 1.00 43.19  ? 504  LEU A CD2 1 
ATOM   1614 N  N   . SER A 1 242 ? -12.028 -34.036 -35.995 1.00 26.39  ? 505  SER A N   1 
ATOM   1615 C  CA  . SER A 1 242 ? -11.135 -34.533 -34.914 1.00 26.26  ? 505  SER A CA  1 
ATOM   1616 C  C   . SER A 1 242 ? -11.963 -35.087 -33.749 1.00 24.42  ? 505  SER A C   1 
ATOM   1617 O  O   . SER A 1 242 ? -11.459 -35.949 -33.041 1.00 22.30  ? 505  SER A O   1 
ATOM   1618 C  CB  . SER A 1 242 ? -10.220 -33.420 -34.444 1.00 25.77  ? 505  SER A CB  1 
ATOM   1619 O  OG  . SER A 1 242 ? -9.501  -32.841 -35.510 1.00 28.37  ? 505  SER A OG  1 
ATOM   1620 N  N   . GLY A 1 243 ? -13.187 -34.596 -33.579 1.00 25.96  ? 506  GLY A N   1 
ATOM   1621 C  CA  . GLY A 1 243 ? -14.053 -34.972 -32.451 1.00 23.72  ? 506  GLY A CA  1 
ATOM   1622 C  C   . GLY A 1 243 ? -14.590 -36.390 -32.564 1.00 23.26  ? 506  GLY A C   1 
ATOM   1623 O  O   . GLY A 1 243 ? -14.499 -36.996 -33.604 1.00 25.73  ? 506  GLY A O   1 
ATOM   1624 N  N   . VAL A 1 244 ? -15.128 -36.866 -31.463 1.00 23.26  ? 507  VAL A N   1 
ATOM   1625 C  CA  . VAL A 1 244 ? -15.734 -38.203 -31.315 1.00 28.75  ? 507  VAL A CA  1 
ATOM   1626 C  C   . VAL A 1 244 ? -17.051 -38.073 -30.524 1.00 29.25  ? 507  VAL A C   1 
ATOM   1627 O  O   . VAL A 1 244 ? -17.509 -39.086 -30.005 1.00 27.29  ? 507  VAL A O   1 
ATOM   1628 C  CB  . VAL A 1 244 ? -14.755 -39.204 -30.664 1.00 26.81  ? 507  VAL A CB  1 
ATOM   1629 C  CG1 . VAL A 1 244 ? -13.546 -39.461 -31.540 1.00 28.94  ? 507  VAL A CG1 1 
ATOM   1630 C  CG2 . VAL A 1 244 ? -14.339 -38.776 -29.278 1.00 29.86  ? 507  VAL A CG2 1 
ATOM   1631 N  N   . GLU A 1 245 ? -17.648 -36.881 -30.422 1.00 30.16  ? 508  GLU A N   1 
ATOM   1632 C  CA  . GLU A 1 245 ? -18.862 -36.703 -29.557 1.00 34.36  ? 508  GLU A CA  1 
ATOM   1633 C  C   . GLU A 1 245 ? -19.990 -37.593 -30.088 1.00 25.10  ? 508  GLU A C   1 
ATOM   1634 O  O   . GLU A 1 245 ? -20.172 -37.680 -31.306 1.00 29.09  ? 508  GLU A O   1 
ATOM   1635 C  CB  . GLU A 1 245 ? -19.350 -35.261 -29.461 1.00 34.45  ? 508  GLU A CB  1 
ATOM   1636 C  CG  . GLU A 1 245 ? -20.440 -35.087 -28.400 1.00 42.17  ? 508  GLU A CG  1 
ATOM   1637 C  CD  . GLU A 1 245 ? -21.871 -35.444 -28.811 1.00 46.14  ? 508  GLU A CD  1 
ATOM   1638 O  OE1 . GLU A 1 245 ? -22.238 -35.255 -30.002 1.00 55.67  ? 508  GLU A OE1 1 
ATOM   1639 O  OE2 . GLU A 1 245 ? -22.633 -35.920 -27.928 1.00 60.04  ? 508  GLU A OE2 1 
ATOM   1640 N  N   . GLY A 1 246 ? -20.600 -38.384 -29.225 1.00 34.78  ? 509  GLY A N   1 
ATOM   1641 C  CA  . GLY A 1 246 ? -21.682 -39.322 -29.634 1.00 36.05  ? 509  GLY A CA  1 
ATOM   1642 C  C   . GLY A 1 246 ? -21.222 -40.612 -30.299 1.00 35.35  ? 509  GLY A C   1 
ATOM   1643 O  O   . GLY A 1 246 ? -22.073 -41.404 -30.727 1.00 32.19  ? 509  GLY A O   1 
ATOM   1644 N  N   . GLU A 1 247 ? -19.905 -40.826 -30.393 0.50 35.09  ? 510  GLU A N   1 
ATOM   1645 C  CA  . GLU A 1 247 ? -19.344 -41.936 -31.200 0.50 36.85  ? 510  GLU A CA  1 
ATOM   1646 C  C   . GLU A 1 247 ? -19.728 -43.262 -30.550 0.50 38.23  ? 510  GLU A C   1 
ATOM   1647 O  O   . GLU A 1 247 ? -20.394 -44.082 -31.230 0.50 43.17  ? 510  GLU A O   1 
ATOM   1648 C  CB  . GLU A 1 247 ? -17.832 -41.814 -31.370 0.50 36.31  ? 510  GLU A CB  1 
ATOM   1649 C  CG  . GLU A 1 247 ? -17.477 -41.147 -32.676 0.50 35.70  ? 510  GLU A CG  1 
ATOM   1650 C  CD  . GLU A 1 247 ? -18.265 -41.719 -33.839 0.50 36.22  ? 510  GLU A CD  1 
ATOM   1651 O  OE1 . GLU A 1 247 ? -18.769 -42.851 -33.704 0.50 37.37  ? 510  GLU A OE1 1 
ATOM   1652 O  OE2 . GLU A 1 247 ? -18.388 -41.035 -34.865 0.50 37.93  ? 510  GLU A OE2 1 
ATOM   1653 N  N   . GLY A 1 248 ? -19.352 -43.440 -29.284 1.00 34.23  ? 511  GLY A N   1 
ATOM   1654 C  CA  . GLY A 1 248 ? -19.525 -44.749 -28.594 1.00 35.71  ? 511  GLY A CA  1 
ATOM   1655 C  C   . GLY A 1 248 ? -18.219 -45.581 -28.567 1.00 34.21  ? 511  GLY A C   1 
ATOM   1656 O  O   . GLY A 1 248 ? -17.405 -45.515 -29.484 1.00 30.11  ? 511  GLY A O   1 
ATOM   1657 N  N   A LEU A 1 249 ? -18.071 -46.406 -27.539 0.25 33.38  ? 512  LEU A N   1 
ATOM   1658 N  N   B LEU A 1 249 ? -18.012 -46.348 -27.490 0.25 33.92  ? 512  LEU A N   1 
ATOM   1659 C  CA  A LEU A 1 249 ? -16.802 -47.088 -27.217 0.25 32.95  ? 512  LEU A CA  1 
ATOM   1660 C  CA  B LEU A 1 249 ? -16.764 -47.120 -27.251 0.25 33.80  ? 512  LEU A CA  1 
ATOM   1661 C  C   A LEU A 1 249 ? -16.524 -48.201 -28.233 0.25 34.11  ? 512  LEU A C   1 
ATOM   1662 C  C   B LEU A 1 249 ? -16.490 -48.024 -28.441 0.25 33.45  ? 512  LEU A C   1 
ATOM   1663 O  O   A LEU A 1 249 ? -15.361 -48.596 -28.351 0.25 37.76  ? 512  LEU A O   1 
ATOM   1664 O  O   B LEU A 1 249 ? -15.326 -48.109 -28.839 0.25 31.74  ? 512  LEU A O   1 
ATOM   1665 C  CB  A LEU A 1 249 ? -16.919 -47.598 -25.780 0.25 33.64  ? 512  LEU A CB  1 
ATOM   1666 C  CB  B LEU A 1 249 ? -16.887 -47.962 -25.980 0.25 37.08  ? 512  LEU A CB  1 
ATOM   1667 C  CG  A LEU A 1 249 ? -15.703 -48.345 -25.266 0.25 29.75  ? 512  LEU A CG  1 
ATOM   1668 C  CG  B LEU A 1 249 ? -16.377 -47.303 -24.705 0.25 34.10  ? 512  LEU A CG  1 
ATOM   1669 C  CD1 A LEU A 1 249 ? -14.450 -47.482 -25.389 0.25 29.33  ? 512  LEU A CD1 1 
ATOM   1670 C  CD1 B LEU A 1 249 ? -16.444 -48.286 -23.552 0.25 34.24  ? 512  LEU A CD1 1 
ATOM   1671 C  CD2 A LEU A 1 249 ? -15.930 -48.769 -23.832 0.25 28.94  ? 512  LEU A CD2 1 
ATOM   1672 C  CD2 B LEU A 1 249 ? -14.954 -46.788 -24.892 0.25 34.54  ? 512  LEU A CD2 1 
ATOM   1673 N  N   . HIS A 1 250 ? -17.549 -48.638 -28.974 0.50 33.98  ? 513  HIS A N   1 
ATOM   1674 C  CA  . HIS A 1 250 ? -17.484 -49.644 -30.070 0.50 32.19  ? 513  HIS A CA  1 
ATOM   1675 C  C   . HIS A 1 250 ? -17.126 -48.993 -31.409 0.50 30.79  ? 513  HIS A C   1 
ATOM   1676 O  O   . HIS A 1 250 ? -17.125 -49.710 -32.436 0.50 29.75  ? 513  HIS A O   1 
ATOM   1677 C  CB  . HIS A 1 250 ? -18.836 -50.354 -30.220 0.50 33.09  ? 513  HIS A CB  1 
ATOM   1678 C  CG  . HIS A 1 250 ? -19.944 -49.413 -30.543 0.50 33.29  ? 513  HIS A CG  1 
ATOM   1679 N  ND1 . HIS A 1 250 ? -20.431 -48.514 -29.612 0.50 33.46  ? 513  HIS A ND1 1 
ATOM   1680 C  CD2 . HIS A 1 250 ? -20.638 -49.204 -31.684 0.50 33.36  ? 513  HIS A CD2 1 
ATOM   1681 C  CE1 . HIS A 1 250 ? -21.393 -47.801 -30.167 0.50 33.80  ? 513  HIS A CE1 1 
ATOM   1682 N  NE2 . HIS A 1 250 ? -21.543 -48.209 -31.437 0.50 34.04  ? 513  HIS A NE2 1 
ATOM   1683 N  N   . LYS A 1 251 ? -16.908 -47.678 -31.424 0.50 31.01  ? 514  LYS A N   1 
ATOM   1684 C  CA  . LYS A 1 251 ? -16.481 -46.946 -32.645 0.50 31.19  ? 514  LYS A CA  1 
ATOM   1685 C  C   . LYS A 1 251 ? -15.045 -46.432 -32.488 0.50 29.07  ? 514  LYS A C   1 
ATOM   1686 O  O   . LYS A 1 251 ? -14.362 -46.276 -33.530 0.50 26.74  ? 514  LYS A O   1 
ATOM   1687 C  CB  . LYS A 1 251 ? -17.455 -45.797 -32.907 0.50 35.31  ? 514  LYS A CB  1 
ATOM   1688 C  CG  . LYS A 1 251 ? -18.913 -46.238 -32.916 0.50 39.91  ? 514  LYS A CG  1 
ATOM   1689 C  CD  . LYS A 1 251 ? -19.452 -46.427 -34.294 0.50 42.89  ? 514  LYS A CD  1 
ATOM   1690 C  CE  . LYS A 1 251 ? -19.774 -45.103 -34.942 0.50 45.27  ? 514  LYS A CE  1 
ATOM   1691 N  NZ  . LYS A 1 251 ? -20.968 -45.214 -35.808 0.50 48.79  ? 514  LYS A NZ  1 
ATOM   1692 N  N   . LEU A 1 252 ? -14.601 -46.174 -31.253 1.00 25.36  ? 515  LEU A N   1 
ATOM   1693 C  CA  . LEU A 1 252 ? -13.327 -45.441 -31.029 1.00 25.92  ? 515  LEU A CA  1 
ATOM   1694 C  C   . LEU A 1 252 ? -12.137 -46.208 -31.588 1.00 23.35  ? 515  LEU A C   1 
ATOM   1695 O  O   . LEU A 1 252 ? -11.260 -45.561 -32.202 1.00 23.70  ? 515  LEU A O   1 
ATOM   1696 C  CB  . LEU A 1 252 ? -13.162 -45.130 -29.559 1.00 24.07  ? 515  LEU A CB  1 
ATOM   1697 C  CG  . LEU A 1 252 ? -14.247 -44.266 -28.951 1.00 24.59  ? 515  LEU A CG  1 
ATOM   1698 C  CD1 . LEU A 1 252 ? -13.879 -43.979 -27.494 1.00 26.45  ? 515  LEU A CD1 1 
ATOM   1699 C  CD2 . LEU A 1 252 ? -14.442 -42.979 -29.749 1.00 27.08  ? 515  LEU A CD2 1 
ATOM   1700 N  N   . GLY A 1 253 ? -12.155 -47.540 -31.508 1.00 21.19  ? 516  GLY A N   1 
ATOM   1701 C  CA  . GLY A 1 253 ? -11.005 -48.308 -32.008 1.00 23.18  ? 516  GLY A CA  1 
ATOM   1702 C  C   . GLY A 1 253 ? -10.981 -48.281 -33.526 1.00 25.08  ? 516  GLY A C   1 
ATOM   1703 O  O   . GLY A 1 253 ? -9.870  -48.077 -34.124 1.00 24.35  ? 516  GLY A O   1 
ATOM   1704 N  N   . TYR A 1 254 ? -12.159 -48.347 -34.155 1.00 25.03  ? 517  TYR A N   1 
ATOM   1705 C  CA  . TYR A 1 254 ? -12.238 -48.227 -35.624 1.00 25.64  ? 517  TYR A CA  1 
ATOM   1706 C  C   . TYR A 1 254 ? -11.727 -46.831 -36.046 1.00 24.27  ? 517  TYR A C   1 
ATOM   1707 O  O   . TYR A 1 254 ? -11.038 -46.697 -37.062 1.00 26.92  ? 517  TYR A O   1 
ATOM   1708 C  CB  . TYR A 1 254 ? -13.652 -48.424 -36.138 1.00 24.66  ? 517  TYR A CB  1 
ATOM   1709 C  CG  . TYR A 1 254 ? -14.119 -49.854 -36.200 1.00 24.26  ? 517  TYR A CG  1 
ATOM   1710 C  CD1 . TYR A 1 254 ? -13.552 -50.774 -37.076 1.00 25.81  ? 517  TYR A CD1 1 
ATOM   1711 C  CD2 . TYR A 1 254 ? -15.062 -50.303 -35.290 1.00 24.29  ? 517  TYR A CD2 1 
ATOM   1712 C  CE1 . TYR A 1 254 ? -13.979 -52.110 -37.101 1.00 26.00  ? 517  TYR A CE1 1 
ATOM   1713 C  CE2 . TYR A 1 254 ? -15.531 -51.612 -35.334 1.00 24.27  ? 517  TYR A CE2 1 
ATOM   1714 C  CZ  . TYR A 1 254 ? -14.982 -52.523 -36.227 1.00 25.17  ? 517  TYR A CZ  1 
ATOM   1715 O  OH  . TYR A 1 254 ? -15.482 -53.812 -36.250 1.00 27.26  ? 517  TYR A OH  1 
ATOM   1716 N  N   . ILE A 1 255 ? -12.093 -45.812 -35.307 1.00 25.50  ? 518  ILE A N   1 
ATOM   1717 C  CA  . ILE A 1 255 ? -11.629 -44.443 -35.600 1.00 26.17  ? 518  ILE A CA  1 
ATOM   1718 C  C   . ILE A 1 255 ? -10.086 -44.371 -35.510 1.00 28.85  ? 518  ILE A C   1 
ATOM   1719 O  O   . ILE A 1 255 ? -9.454  -43.794 -36.442 1.00 28.44  ? 518  ILE A O   1 
ATOM   1720 C  CB  . ILE A 1 255 ? -12.364 -43.451 -34.703 1.00 27.08  ? 518  ILE A CB  1 
ATOM   1721 C  CG1 . ILE A 1 255 ? -13.834 -43.344 -35.147 1.00 26.24  ? 518  ILE A CG1 1 
ATOM   1722 C  CG2 . ILE A 1 255 ? -11.635 -42.097 -34.685 1.00 25.81  ? 518  ILE A CG2 1 
ATOM   1723 C  CD1 . ILE A 1 255 ? -14.731 -42.543 -34.176 1.00 29.32  ? 518  ILE A CD1 1 
ATOM   1724 N  N   . LEU A 1 256 ? -9.471  -44.893 -34.452 1.00 27.42  ? 519  LEU A N   1 
ATOM   1725 C  CA  . LEU A 1 256 ? -7.996  -44.858 -34.318 1.00 27.86  ? 519  LEU A CA  1 
ATOM   1726 C  C   . LEU A 1 256 ? -7.337  -45.629 -35.463 1.00 29.88  ? 519  LEU A C   1 
ATOM   1727 O  O   . LEU A 1 256 ? -6.259  -45.175 -35.889 1.00 28.97  ? 519  LEU A O   1 
ATOM   1728 C  CB  . LEU A 1 256 ? -7.565  -45.453 -32.973 1.00 28.87  ? 519  LEU A CB  1 
ATOM   1729 C  CG  . LEU A 1 256 ? -7.900  -44.654 -31.717 1.00 29.95  ? 519  LEU A CG  1 
ATOM   1730 C  CD1 . LEU A 1 256 ? -7.207  -45.316 -30.526 1.00 35.10  ? 519  LEU A CD1 1 
ATOM   1731 C  CD2 . LEU A 1 256 ? -7.445  -43.205 -31.815 1.00 31.29  ? 519  LEU A CD2 1 
ATOM   1732 N  N   . ARG A 1 257 ? -7.909  -46.779 -35.891 1.00 27.14  ? 520  ARG A N   1 
ATOM   1733 C  CA  . ARG A 1 257 ? -7.331  -47.588 -37.000 1.00 30.22  ? 520  ARG A CA  1 
ATOM   1734 C  C   . ARG A 1 257 ? -7.432  -46.753 -38.275 1.00 31.23  ? 520  ARG A C   1 
ATOM   1735 O  O   . ARG A 1 257 ? -6.483  -46.782 -39.079 1.00 27.63  ? 520  ARG A O   1 
ATOM   1736 C  CB  . ARG A 1 257 ? -8.002  -48.955 -37.125 1.00 29.74  ? 520  ARG A CB  1 
ATOM   1737 C  CG  . ARG A 1 257 ? -7.449  -49.824 -38.256 1.00 32.13  ? 520  ARG A CG  1 
ATOM   1738 C  CD  . ARG A 1 257 ? -8.222  -51.132 -38.311 1.00 28.01  ? 520  ARG A CD  1 
ATOM   1739 N  NE  . ARG A 1 257 ? -9.546  -50.963 -38.902 1.00 29.06  ? 520  ARG A NE  1 
ATOM   1740 C  CZ  . ARG A 1 257 ? -10.311 -51.958 -39.367 1.00 26.66  ? 520  ARG A CZ  1 
ATOM   1741 N  NH1 . ARG A 1 257 ? -9.957  -53.211 -39.219 1.00 30.28  ? 520  ARG A NH1 1 
ATOM   1742 N  NH2 . ARG A 1 257 ? -11.444 -51.680 -39.929 1.00 27.71  ? 520  ARG A NH2 1 
ATOM   1743 N  N   . ASP A 1 258 ? -8.483  -45.954 -38.427 1.00 27.79  ? 521  ASP A N   1 
ATOM   1744 C  CA  . ASP A 1 258 ? -8.607  -45.100 -39.657 1.00 29.72  ? 521  ASP A CA  1 
ATOM   1745 C  C   . ASP A 1 258 ? -7.515  -44.001 -39.625 1.00 29.44  ? 521  ASP A C   1 
ATOM   1746 O  O   . ASP A 1 258 ? -6.912  -43.757 -40.617 1.00 32.34  ? 521  ASP A O   1 
ATOM   1747 C  CB  . ASP A 1 258 ? -10.003 -44.496 -39.877 1.00 29.37  ? 521  ASP A CB  1 
ATOM   1748 C  CG  . ASP A 1 258 ? -11.005 -45.436 -40.554 1.00 31.76  ? 521  ASP A CG  1 
ATOM   1749 O  OD1 . ASP A 1 258 ? -10.597 -46.522 -40.989 1.00 34.52  ? 521  ASP A OD1 1 
ATOM   1750 O  OD2 . ASP A 1 258 ? -12.184 -45.105 -40.569 1.00 37.18  ? 521  ASP A OD2 1 
ATOM   1751 N  N   . VAL A 1 259 ? -7.268  -43.360 -38.511 1.00 27.33  ? 522  VAL A N   1 
ATOM   1752 C  CA  . VAL A 1 259 ? -6.146  -42.394 -38.365 1.00 29.14  ? 522  VAL A CA  1 
ATOM   1753 C  C   . VAL A 1 259 ? -4.817  -43.107 -38.682 1.00 31.93  ? 522  VAL A C   1 
ATOM   1754 O  O   . VAL A 1 259 ? -3.997  -42.547 -39.367 1.00 32.19  ? 522  VAL A O   1 
ATOM   1755 C  CB  . VAL A 1 259 ? -6.123  -41.829 -36.942 1.00 31.23  ? 522  VAL A CB  1 
ATOM   1756 C  CG1 . VAL A 1 259 ? -4.851  -40.995 -36.745 1.00 34.34  ? 522  VAL A CG1 1 
ATOM   1757 C  CG2 . VAL A 1 259 ? -7.359  -41.002 -36.646 1.00 29.00  ? 522  VAL A CG2 1 
ATOM   1758 N  N   . SER A 1 260 ? -4.607  -44.326 -38.220 1.00 28.79  ? 523  SER A N   1 
ATOM   1759 C  CA  . SER A 1 260 ? -3.356  -45.083 -38.443 1.00 30.09  ? 523  SER A CA  1 
ATOM   1760 C  C   . SER A 1 260 ? -3.099  -45.259 -39.942 1.00 33.36  ? 523  SER A C   1 
ATOM   1761 O  O   . SER A 1 260 ? -1.931  -45.393 -40.303 1.00 30.51  ? 523  SER A O   1 
ATOM   1762 C  CB  . SER A 1 260 ? -3.338  -46.425 -37.735 1.00 30.21  ? 523  SER A CB  1 
ATOM   1763 O  OG  . SER A 1 260 ? -3.994  -47.418 -38.511 1.00 31.74  ? 523  SER A OG  1 
ATOM   1764 N  N   . LYS A 1 261 ? -4.123  -45.215 -40.779 1.00 31.98  ? 524  LYS A N   1 
ATOM   1765 C  CA  . LYS A 1 261 ? -3.990  -45.510 -42.234 1.00 34.91  ? 524  LYS A CA  1 
ATOM   1766 C  C   . LYS A 1 261 ? -3.384  -44.326 -42.987 1.00 35.96  ? 524  LYS A C   1 
ATOM   1767 O  O   . LYS A 1 261 ? -2.975  -44.520 -44.133 1.00 35.60  ? 524  LYS A O   1 
ATOM   1768 C  CB  . LYS A 1 261 ? -5.345  -45.821 -42.854 1.00 40.40  ? 524  LYS A CB  1 
ATOM   1769 C  CG  . LYS A 1 261 ? -5.808  -47.229 -42.560 1.00 45.06  ? 524  LYS A CG  1 
ATOM   1770 C  CD  . LYS A 1 261 ? -7.187  -47.486 -43.091 1.00 54.87  ? 524  LYS A CD  1 
ATOM   1771 C  CE  . LYS A 1 261 ? -7.614  -48.898 -42.795 1.00 58.98  ? 524  LYS A CE  1 
ATOM   1772 N  NZ  . LYS A 1 261 ? -9.005  -48.873 -42.305 1.00 79.75  ? 524  LYS A NZ  1 
ATOM   1773 N  N   . LYS A 1 262 ? -3.413  -43.134 -42.410 1.00 34.45  ? 525  LYS A N   1 
ATOM   1774 C  CA  . LYS A 1 262 ? -2.799  -41.936 -43.019 1.00 39.60  ? 525  LYS A CA  1 
ATOM   1775 C  C   . LYS A 1 262 ? -1.292  -42.140 -43.090 1.00 42.81  ? 525  LYS A C   1 
ATOM   1776 O  O   . LYS A 1 262 ? -0.724  -42.726 -42.161 1.00 40.21  ? 525  LYS A O   1 
ATOM   1777 C  CB  . LYS A 1 262 ? -3.134  -40.718 -42.164 1.00 38.77  ? 525  LYS A CB  1 
ATOM   1778 C  CG  . LYS A 1 262 ? -4.631  -40.452 -42.166 1.00 41.36  ? 525  LYS A CG  1 
ATOM   1779 C  CD  . LYS A 1 262 ? -4.976  -39.025 -42.149 1.00 46.13  ? 525  LYS A CD  1 
ATOM   1780 C  CE  . LYS A 1 262 ? -6.452  -38.793 -42.279 1.00 49.58  ? 525  LYS A CE  1 
ATOM   1781 N  NZ  . LYS A 1 262 ? -6.672  -37.778 -43.340 1.00 57.73  ? 525  LYS A NZ  1 
ATOM   1782 N  N   . GLU A 1 263 ? -0.663  -41.651 -44.147 1.00 40.70  ? 526  GLU A N   1 
ATOM   1783 C  CA  . GLU A 1 263 ? 0.816   -41.565 -44.181 1.00 40.82  ? 526  GLU A CA  1 
ATOM   1784 C  C   . GLU A 1 263 ? 1.229   -40.609 -43.057 1.00 36.46  ? 526  GLU A C   1 
ATOM   1785 O  O   . GLU A 1 263 ? 0.584   -39.569 -42.899 1.00 36.57  ? 526  GLU A O   1 
ATOM   1786 C  CB  . GLU A 1 263 ? 1.291   -41.074 -45.552 1.00 47.04  ? 526  GLU A CB  1 
ATOM   1787 C  CG  . GLU A 1 263 ? 1.010   -42.049 -46.702 1.00 54.36  ? 526  GLU A CG  1 
ATOM   1788 C  CD  . GLU A 1 263 ? 1.650   -43.429 -46.580 1.00 64.33  ? 526  GLU A CD  1 
ATOM   1789 O  OE1 . GLU A 1 263 ? 2.801   -43.513 -46.077 1.00 61.52  ? 526  GLU A OE1 1 
ATOM   1790 O  OE2 . GLU A 1 263 ? 0.991   -44.432 -46.972 1.00 69.83  ? 526  GLU A OE2 1 
ATOM   1791 N  N   . GLY A 1 264 ? 2.259   -40.949 -42.306 1.00 33.04  ? 527  GLY A N   1 
ATOM   1792 C  CA  . GLY A 1 264 ? 2.889   -39.940 -41.448 1.00 34.79  ? 527  GLY A CA  1 
ATOM   1793 C  C   . GLY A 1 264 ? 3.757   -40.575 -40.407 1.00 36.96  ? 527  GLY A C   1 
ATOM   1794 O  O   . GLY A 1 264 ? 4.238   -41.671 -40.639 1.00 36.73  ? 527  GLY A O   1 
ATOM   1795 N  N   . GLY A 1 265 ? 3.911   -39.915 -39.272 1.00 37.39  ? 528  GLY A N   1 
ATOM   1796 C  CA  . GLY A 1 265 ? 4.829   -40.362 -38.217 1.00 37.89  ? 528  GLY A CA  1 
ATOM   1797 C  C   . GLY A 1 265 ? 4.155   -41.280 -37.209 1.00 39.97  ? 528  GLY A C   1 
ATOM   1798 O  O   . GLY A 1 265 ? 3.173   -41.945 -37.571 1.00 39.41  ? 528  GLY A O   1 
ATOM   1799 N  N   . ALA A 1 266 ? 4.737   -41.376 -36.025 1.00 32.91  ? 529  ALA A N   1 
ATOM   1800 C  CA  . ALA A 1 266 ? 4.188   -42.116 -34.875 1.00 31.52  ? 529  ALA A CA  1 
ATOM   1801 C  C   . ALA A 1 266 ? 2.819   -41.531 -34.493 1.00 30.80  ? 529  ALA A C   1 
ATOM   1802 O  O   . ALA A 1 266 ? 2.466   -40.429 -34.958 1.00 28.16  ? 529  ALA A O   1 
ATOM   1803 C  CB  . ALA A 1 266 ? 5.171   -42.059 -33.722 1.00 29.05  ? 529  ALA A CB  1 
ATOM   1804 N  N   . MET A 1 267 ? 2.043   -42.269 -33.698 1.00 29.60  ? 530  MET A N   1 
ATOM   1805 C  CA  . MET A 1 267 ? 0.814   -41.749 -33.050 1.00 28.95  ? 530  MET A CA  1 
ATOM   1806 C  C   . MET A 1 267 ? 1.211   -41.185 -31.675 1.00 27.93  ? 530  MET A C   1 
ATOM   1807 O  O   . MET A 1 267 ? 1.847   -41.886 -30.867 1.00 32.77  ? 530  MET A O   1 
ATOM   1808 C  CB  . MET A 1 267 ? -0.240  -42.878 -32.980 1.00 30.98  ? 530  MET A CB  1 
ATOM   1809 C  CG  . MET A 1 267 ? -0.688  -43.287 -34.358 1.00 33.15  ? 530  MET A CG  1 
ATOM   1810 S  SD  . MET A 1 267 ? -2.059  -44.490 -34.520 1.00 38.00  ? 530  MET A SD  1 
ATOM   1811 C  CE  . MET A 1 267 ? -3.511  -43.483 -34.296 1.00 38.45  ? 530  MET A CE  1 
ATOM   1812 N  N   . TYR A 1 268 ? 0.928   -39.919 -31.429 1.00 23.30  ? 531  TYR A N   1 
ATOM   1813 C  CA  . TYR A 1 268 ? 1.235   -39.239 -30.159 1.00 24.62  ? 531  TYR A CA  1 
ATOM   1814 C  C   . TYR A 1 268 ? -0.042  -39.169 -29.347 1.00 23.57  ? 531  TYR A C   1 
ATOM   1815 O  O   . TYR A 1 268 ? -1.174  -38.823 -29.900 1.00 27.96  ? 531  TYR A O   1 
ATOM   1816 C  CB  . TYR A 1 268 ? 1.872   -37.890 -30.469 1.00 23.30  ? 531  TYR A CB  1 
ATOM   1817 C  CG  . TYR A 1 268 ? 3.194   -38.040 -31.172 1.00 28.57  ? 531  TYR A CG  1 
ATOM   1818 C  CD1 . TYR A 1 268 ? 3.252   -38.214 -32.546 1.00 27.36  ? 531  TYR A CD1 1 
ATOM   1819 C  CD2 . TYR A 1 268 ? 4.375   -38.148 -30.455 1.00 28.85  ? 531  TYR A CD2 1 
ATOM   1820 C  CE1 . TYR A 1 268 ? 4.472   -38.411 -33.180 1.00 29.88  ? 531  TYR A CE1 1 
ATOM   1821 C  CE2 . TYR A 1 268 ? 5.590   -38.372 -31.084 1.00 31.84  ? 531  TYR A CE2 1 
ATOM   1822 C  CZ  . TYR A 1 268 ? 5.648   -38.502 -32.453 1.00 32.59  ? 531  TYR A CZ  1 
ATOM   1823 O  OH  . TYR A 1 268 ? 6.839   -38.697 -33.123 1.00 29.91  ? 531  TYR A OH  1 
ATOM   1824 N  N   . ALA A 1 269 ? 0.090   -39.408 -28.056 1.00 23.77  ? 532  ALA A N   1 
ATOM   1825 C  CA  . ALA A 1 269 ? -1.067  -39.362 -27.159 1.00 26.41  ? 532  ALA A CA  1 
ATOM   1826 C  C   . ALA A 1 269 ? -0.596  -38.766 -25.857 1.00 32.87  ? 532  ALA A C   1 
ATOM   1827 O  O   . ALA A 1 269 ? -0.576  -39.473 -24.838 1.00 32.40  ? 532  ALA A O   1 
ATOM   1828 C  CB  . ALA A 1 269 ? -1.659  -40.748 -27.026 1.00 28.62  ? 532  ALA A CB  1 
ATOM   1829 N  N   . ASP A 1 270 ? -0.208  -37.505 -25.882 1.00 28.37  ? 533  ASP A N   1 
ATOM   1830 C  CA  . ASP A 1 270 ? 0.355   -36.898 -24.664 1.00 28.33  ? 533  ASP A CA  1 
ATOM   1831 C  C   . ASP A 1 270 ? -0.802  -36.414 -23.797 1.00 32.13  ? 533  ASP A C   1 
ATOM   1832 O  O   . ASP A 1 270 ? -1.614  -35.666 -24.290 1.00 29.37  ? 533  ASP A O   1 
ATOM   1833 C  CB  . ASP A 1 270 ? 1.293   -35.735 -24.992 1.00 30.22  ? 533  ASP A CB  1 
ATOM   1834 C  CG  . ASP A 1 270 ? 2.565   -36.120 -25.748 1.00 35.08  ? 533  ASP A CG  1 
ATOM   1835 O  OD1 . ASP A 1 270 ? 2.897   -37.328 -25.763 1.00 34.57  ? 533  ASP A OD1 1 
ATOM   1836 O  OD2 . ASP A 1 270 ? 3.151   -35.234 -26.383 1.00 33.17  ? 533  ASP A OD2 1 
ATOM   1837 N  N   . ASP A 1 271 ? -0.792  -36.719 -22.514 1.00 34.70  ? 534  ASP A N   1 
ATOM   1838 C  CA  . ASP A 1 271 ? -1.769  -36.200 -21.518 1.00 38.80  ? 534  ASP A CA  1 
ATOM   1839 C  C   . ASP A 1 271 ? -1.260  -34.857 -21.005 1.00 36.15  ? 534  ASP A C   1 
ATOM   1840 O  O   . ASP A 1 271 ? -0.031  -34.691 -20.923 1.00 36.46  ? 534  ASP A O   1 
ATOM   1841 C  CB  . ASP A 1 271 ? -2.007  -37.219 -20.400 1.00 41.91  ? 534  ASP A CB  1 
ATOM   1842 C  CG  . ASP A 1 271 ? -3.040  -38.282 -20.771 1.00 50.82  ? 534  ASP A CG  1 
ATOM   1843 O  OD1 . ASP A 1 271 ? -3.838  -38.077 -21.735 1.00 51.57  ? 534  ASP A OD1 1 
ATOM   1844 O  OD2 . ASP A 1 271 ? -3.065  -39.316 -20.122 1.00 47.35  ? 534  ASP A OD2 1 
ATOM   1845 N  N   . THR A 1 272 ? -2.161  -33.898 -20.796 1.00 32.11  ? 535  THR A N   1 
ATOM   1846 C  CA  . THR A 1 272 ? -1.881  -32.627 -20.093 1.00 31.03  ? 535  THR A CA  1 
ATOM   1847 C  C   . THR A 1 272 ? -1.946  -32.883 -18.595 1.00 31.71  ? 535  THR A C   1 
ATOM   1848 O  O   . THR A 1 272 ? -2.834  -33.550 -18.153 1.00 33.56  ? 535  THR A O   1 
ATOM   1849 C  CB  . THR A 1 272 ? -2.782  -31.502 -20.581 1.00 33.27  ? 535  THR A CB  1 
ATOM   1850 O  OG1 . THR A 1 272 ? -2.578  -31.447 -21.994 1.00 33.03  ? 535  THR A OG1 1 
ATOM   1851 C  CG2 . THR A 1 272 ? -2.445  -30.154 -20.001 1.00 35.99  ? 535  THR A CG2 1 
ATOM   1852 N  N   . ALA A 1 273 ? -1.028  -32.296 -17.848 1.00 36.66  ? 536  ALA A N   1 
ATOM   1853 C  CA  . ALA A 1 273 ? -1.096  -32.219 -16.374 1.00 39.17  ? 536  ALA A CA  1 
ATOM   1854 C  C   . ALA A 1 273 ? -2.151  -31.172 -15.960 1.00 36.22  ? 536  ALA A C   1 
ATOM   1855 O  O   . ALA A 1 273 ? -1.944  -29.997 -16.194 1.00 43.62  ? 536  ALA A O   1 
ATOM   1856 C  CB  . ALA A 1 273 ? 0.299   -31.918 -15.872 1.00 40.28  ? 536  ALA A CB  1 
ATOM   1857 N  N   . GLY A 1 274 ? -3.299  -31.613 -15.451 1.00 41.60  ? 537  GLY A N   1 
ATOM   1858 C  CA  . GLY A 1 274 ? -4.380  -30.762 -14.910 1.00 41.72  ? 537  GLY A CA  1 
ATOM   1859 C  C   . GLY A 1 274 ? -4.939  -29.801 -15.946 1.00 41.26  ? 537  GLY A C   1 
ATOM   1860 O  O   . GLY A 1 274 ? -4.912  -28.570 -15.716 1.00 40.96  ? 537  GLY A O   1 
ATOM   1861 N  N   . TRP A 1 275 ? -5.494  -30.329 -17.035 1.00 34.91  ? 538  TRP A N   1 
ATOM   1862 C  CA  . TRP A 1 275 ? -5.980  -29.502 -18.171 1.00 34.68  ? 538  TRP A CA  1 
ATOM   1863 C  C   . TRP A 1 275 ? -6.861  -28.325 -17.702 1.00 31.57  ? 538  TRP A C   1 
ATOM   1864 O  O   . TRP A 1 275 ? -6.572  -27.194 -18.154 1.00 31.74  ? 538  TRP A O   1 
ATOM   1865 C  CB  . TRP A 1 275 ? -6.706  -30.355 -19.203 1.00 33.07  ? 538  TRP A CB  1 
ATOM   1866 C  CG  . TRP A 1 275 ? -7.313  -29.521 -20.298 1.00 31.20  ? 538  TRP A CG  1 
ATOM   1867 C  CD1 . TRP A 1 275 ? -8.533  -28.926 -20.272 1.00 31.17  ? 538  TRP A CD1 1 
ATOM   1868 C  CD2 . TRP A 1 275 ? -6.775  -29.261 -21.600 1.00 28.64  ? 538  TRP A CD2 1 
ATOM   1869 N  NE1 . TRP A 1 275 ? -8.782  -28.310 -21.458 1.00 33.20  ? 538  TRP A NE1 1 
ATOM   1870 C  CE2 . TRP A 1 275 ? -7.706  -28.461 -22.278 1.00 32.25  ? 538  TRP A CE2 1 
ATOM   1871 C  CE3 . TRP A 1 275 ? -5.588  -29.595 -22.255 1.00 30.00  ? 538  TRP A CE3 1 
ATOM   1872 C  CZ2 . TRP A 1 275 ? -7.483  -27.974 -23.561 1.00 29.79  ? 538  TRP A CZ2 1 
ATOM   1873 C  CZ3 . TRP A 1 275 ? -5.378  -29.129 -23.524 1.00 31.53  ? 538  TRP A CZ3 1 
ATOM   1874 C  CH2 . TRP A 1 275 ? -6.315  -28.332 -24.168 1.00 35.94  ? 538  TRP A CH2 1 
ATOM   1875 N  N   . ASP A 1 276 ? -7.854  -28.557 -16.854 1.00 35.57  ? 539  ASP A N   1 
ATOM   1876 C  CA  . ASP A 1 276 ? -8.856  -27.521 -16.431 1.00 38.68  ? 539  ASP A CA  1 
ATOM   1877 C  C   . ASP A 1 276 ? -8.137  -26.351 -15.740 1.00 41.30  ? 539  ASP A C   1 
ATOM   1878 O  O   . ASP A 1 276 ? -8.525  -25.161 -15.979 1.00 40.86  ? 539  ASP A O   1 
ATOM   1879 C  CB  . ASP A 1 276 ? -9.969  -28.146 -15.595 1.00 39.02  ? 539  ASP A CB  1 
ATOM   1880 C  CG  . ASP A 1 276 ? -10.982 -28.880 -16.470 1.00 42.08  ? 539  ASP A CG  1 
ATOM   1881 O  OD1 . ASP A 1 276 ? -10.836 -28.835 -17.712 1.00 45.21  ? 539  ASP A OD1 1 
ATOM   1882 O  OD2 . ASP A 1 276 ? -11.883 -29.496 -15.932 1.00 47.80  ? 539  ASP A OD2 1 
ATOM   1883 N  N   . THR A 1 277 ? -7.044  -26.635 -15.035 1.00 42.25  ? 540  THR A N   1 
ATOM   1884 C  CA  . THR A 1 277 ? -6.247  -25.594 -14.328 1.00 41.67  ? 540  THR A CA  1 
ATOM   1885 C  C   . THR A 1 277 ? -5.337  -24.793 -15.264 1.00 42.37  ? 540  THR A C   1 
ATOM   1886 O  O   . THR A 1 277 ? -4.874  -23.770 -14.836 1.00 46.75  ? 540  THR A O   1 
ATOM   1887 C  CB  . THR A 1 277 ? -5.429  -26.165 -13.152 1.00 41.07  ? 540  THR A CB  1 
ATOM   1888 O  OG1 . THR A 1 277 ? -4.412  -27.069 -13.571 1.00 48.26  ? 540  THR A OG1 1 
ATOM   1889 C  CG2 . THR A 1 277 ? -6.291  -26.918 -12.171 1.00 43.04  ? 540  THR A CG2 1 
ATOM   1890 N  N   . ARG A 1 278 ? -5.110  -25.264 -16.498 0.50 39.52  ? 541  ARG A N   1 
ATOM   1891 C  CA  . ARG A 1 278 ? -4.182  -24.636 -17.481 0.50 38.64  ? 541  ARG A CA  1 
ATOM   1892 C  C   . ARG A 1 278 ? -4.948  -23.819 -18.527 0.50 37.52  ? 541  ARG A C   1 
ATOM   1893 O  O   . ARG A 1 278 ? -4.293  -23.349 -19.469 0.50 36.41  ? 541  ARG A O   1 
ATOM   1894 C  CB  . ARG A 1 278 ? -3.357  -25.711 -18.195 0.50 40.78  ? 541  ARG A CB  1 
ATOM   1895 C  CG  . ARG A 1 278 ? -2.728  -26.731 -17.260 0.50 42.00  ? 541  ARG A CG  1 
ATOM   1896 C  CD  . ARG A 1 278 ? -1.375  -26.299 -16.740 0.50 45.13  ? 541  ARG A CD  1 
ATOM   1897 N  NE  . ARG A 1 278 ? -0.607  -27.413 -16.180 0.50 47.32  ? 541  ARG A NE  1 
ATOM   1898 C  CZ  . ARG A 1 278 ? 0.665   -27.321 -15.820 0.50 47.99  ? 541  ARG A CZ  1 
ATOM   1899 N  NH1 . ARG A 1 278 ? 1.311   -26.182 -16.003 0.50 51.93  ? 541  ARG A NH1 1 
ATOM   1900 N  NH2 . ARG A 1 278 ? 1.291   -28.356 -15.295 0.50 49.73  ? 541  ARG A NH2 1 
ATOM   1901 N  N   . ILE A 1 279 ? -6.273  -23.686 -18.391 1.00 36.48  ? 542  ILE A N   1 
ATOM   1902 C  CA  . ILE A 1 279 ? -7.097  -22.859 -19.316 1.00 37.67  ? 542  ILE A CA  1 
ATOM   1903 C  C   . ILE A 1 279 ? -6.823  -21.378 -18.986 1.00 35.05  ? 542  ILE A C   1 
ATOM   1904 O  O   . ILE A 1 279 ? -7.102  -20.946 -17.892 1.00 39.86  ? 542  ILE A O   1 
ATOM   1905 C  CB  . ILE A 1 279 ? -8.584  -23.265 -19.227 1.00 38.40  ? 542  ILE A CB  1 
ATOM   1906 C  CG1 . ILE A 1 279 ? -8.794  -24.636 -19.879 1.00 39.89  ? 542  ILE A CG1 1 
ATOM   1907 C  CG2 . ILE A 1 279 ? -9.512  -22.224 -19.867 1.00 37.80  ? 542  ILE A CG2 1 
ATOM   1908 C  CD1 . ILE A 1 279 ? -8.609  -24.602 -21.368 1.00 40.68  ? 542  ILE A CD1 1 
ATOM   1909 N  N   . THR A 1 280 ? -6.245  -20.634 -19.911 1.00 40.27  ? 543  THR A N   1 
ATOM   1910 C  CA  . THR A 1 280 ? -5.844  -19.227 -19.678 1.00 41.57  ? 543  THR A CA  1 
ATOM   1911 C  C   . THR A 1 280 ? -7.013  -18.298 -19.972 1.00 43.04  ? 543  THR A C   1 
ATOM   1912 O  O   . THR A 1 280 ? -8.033  -18.742 -20.611 1.00 40.96  ? 543  THR A O   1 
ATOM   1913 C  CB  . THR A 1 280 ? -4.631  -18.890 -20.531 1.00 35.73  ? 543  THR A CB  1 
ATOM   1914 O  OG1 . THR A 1 280 ? -5.020  -18.989 -21.896 1.00 40.18  ? 543  THR A OG1 1 
ATOM   1915 C  CG2 . THR A 1 280 ? -3.497  -19.830 -20.232 1.00 42.56  ? 543  THR A CG2 1 
ATOM   1916 N  N   . LEU A 1 281 ? -6.879  -17.026 -19.600 1.00 43.04  ? 544  LEU A N   1 
ATOM   1917 C  CA  . LEU A 1 281 ? -7.916  -16.038 -19.981 1.00 40.56  ? 544  LEU A CA  1 
ATOM   1918 C  C   . LEU A 1 281 ? -7.876  -15.900 -21.508 1.00 37.32  ? 544  LEU A C   1 
ATOM   1919 O  O   . LEU A 1 281 ? -8.916  -15.673 -22.101 1.00 37.11  ? 544  LEU A O   1 
ATOM   1920 C  CB  . LEU A 1 281 ? -7.685  -14.707 -19.239 1.00 55.01  ? 544  LEU A CB  1 
ATOM   1921 C  CG  . LEU A 1 281 ? -8.605  -13.555 -19.660 1.00 58.75  ? 544  LEU A CG  1 
ATOM   1922 C  CD1 . LEU A 1 281 ? -10.096 -13.926 -19.559 1.00 54.70  ? 544  LEU A CD1 1 
ATOM   1923 C  CD2 . LEU A 1 281 ? -8.308  -12.301 -18.842 1.00 60.12  ? 544  LEU A CD2 1 
ATOM   1924 N  N   . GLU A 1 282 ? -6.736  -16.124 -22.172 1.00 37.53  ? 545  GLU A N   1 
ATOM   1925 C  CA  . GLU A 1 282 ? -6.706  -16.017 -23.656 1.00 38.86  ? 545  GLU A CA  1 
ATOM   1926 C  C   . GLU A 1 282 ? -7.532  -17.153 -24.280 1.00 42.55  ? 545  GLU A C   1 
ATOM   1927 O  O   . GLU A 1 282 ? -8.288  -16.914 -25.273 1.00 38.45  ? 545  GLU A O   1 
ATOM   1928 C  CB  . GLU A 1 282 ? -5.253  -15.986 -24.103 1.00 50.94  ? 545  GLU A CB  1 
ATOM   1929 C  CG  . GLU A 1 282 ? -5.060  -15.226 -25.397 1.00 66.05  ? 545  GLU A CG  1 
ATOM   1930 C  CD  . GLU A 1 282 ? -5.286  -13.721 -25.366 1.00 62.13  ? 545  GLU A CD  1 
ATOM   1931 O  OE1 . GLU A 1 282 ? -5.370  -13.138 -24.258 1.00 66.77  ? 545  GLU A OE1 1 
ATOM   1932 O  OE2 . GLU A 1 282 ? -5.391  -13.145 -26.469 1.00 71.98  ? 545  GLU A OE2 1 
ATOM   1933 N  N   . ASP A 1 283 ? -7.415  -18.358 -23.715 1.00 38.43  ? 546  ASP A N   1 
ATOM   1934 C  CA  . ASP A 1 283 ? -8.281  -19.523 -24.066 1.00 35.33  ? 546  ASP A CA  1 
ATOM   1935 C  C   . ASP A 1 283 ? -9.783  -19.152 -23.929 1.00 35.70  ? 546  ASP A C   1 
ATOM   1936 O  O   . ASP A 1 283 ? -10.533 -19.339 -24.902 1.00 39.70  ? 546  ASP A O   1 
ATOM   1937 C  CB  . ASP A 1 283 ? -7.920  -20.716 -23.178 1.00 33.31  ? 546  ASP A CB  1 
ATOM   1938 C  CG  . ASP A 1 283 ? -6.566  -21.368 -23.486 1.00 31.70  ? 546  ASP A CG  1 
ATOM   1939 O  OD1 . ASP A 1 283 ? -6.079  -21.256 -24.641 1.00 32.80  ? 546  ASP A OD1 1 
ATOM   1940 O  OD2 . ASP A 1 283 ? -6.054  -22.049 -22.590 1.00 33.00  ? 546  ASP A OD2 1 
ATOM   1941 N  N   . LEU A 1 284 ? -10.216 -18.606 -22.796 1.00 34.47  ? 547  LEU A N   1 
ATOM   1942 C  CA  . LEU A 1 284 ? -11.642 -18.226 -22.564 1.00 36.51  ? 547  LEU A CA  1 
ATOM   1943 C  C   . LEU A 1 284 ? -12.158 -17.187 -23.583 1.00 38.42  ? 547  LEU A C   1 
ATOM   1944 O  O   . LEU A 1 284 ? -13.333 -17.261 -23.963 1.00 39.73  ? 547  LEU A O   1 
ATOM   1945 C  CB  . LEU A 1 284 ? -11.785 -17.741 -21.124 1.00 38.46  ? 547  LEU A CB  1 
ATOM   1946 C  CG  . LEU A 1 284 ? -11.468 -18.786 -20.055 1.00 37.33  ? 547  LEU A CG  1 
ATOM   1947 C  CD1 . LEU A 1 284 ? -11.353 -18.128 -18.700 1.00 48.84  ? 547  LEU A CD1 1 
ATOM   1948 C  CD2 . LEU A 1 284 ? -12.511 -19.882 -19.973 1.00 40.38  ? 547  LEU A CD2 1 
ATOM   1949 N  N   . LYS A 1 285 ? -11.290 -16.258 -24.004 0.50 39.74  ? 548  LYS A N   1 
ATOM   1950 C  CA  . LYS A 1 285 ? -11.591 -15.213 -25.021 0.50 42.25  ? 548  LYS A CA  1 
ATOM   1951 C  C   . LYS A 1 285 ? -11.761 -15.877 -26.392 0.50 41.85  ? 548  LYS A C   1 
ATOM   1952 O  O   . LYS A 1 285 ? -12.757 -15.561 -27.063 0.50 40.96  ? 548  LYS A O   1 
ATOM   1953 C  CB  . LYS A 1 285 ? -10.502 -14.133 -25.034 0.50 44.84  ? 548  LYS A CB  1 
ATOM   1954 C  CG  . LYS A 1 285 ? -10.495 -13.223 -23.812 0.50 47.50  ? 548  LYS A CG  1 
ATOM   1955 C  CD  . LYS A 1 285 ? -9.467  -12.108 -23.870 0.50 51.48  ? 548  LYS A CD  1 
ATOM   1956 C  CE  . LYS A 1 285 ? -9.549  -11.166 -22.682 0.50 53.80  ? 548  LYS A CE  1 
ATOM   1957 N  NZ  . LYS A 1 285 ? -8.477  -10.139 -22.717 0.50 57.81  ? 548  LYS A NZ  1 
ATOM   1958 N  N   . ASN A 1 286 ? -10.854 -16.783 -26.775 1.00 38.15  ? 549  ASN A N   1 
ATOM   1959 C  CA  . ASN A 1 286 ? -10.963 -17.490 -28.072 1.00 35.76  ? 549  ASN A CA  1 
ATOM   1960 C  C   . ASN A 1 286 ? -12.230 -18.359 -28.095 1.00 32.84  ? 549  ASN A C   1 
ATOM   1961 O  O   . ASN A 1 286 ? -12.909 -18.417 -29.144 1.00 33.14  ? 549  ASN A O   1 
ATOM   1962 C  CB  . ASN A 1 286 ? -9.700  -18.286 -28.346 1.00 39.12  ? 549  ASN A CB  1 
ATOM   1963 C  CG  . ASN A 1 286 ? -8.525  -17.357 -28.576 1.00 47.92  ? 549  ASN A CG  1 
ATOM   1964 O  OD1 . ASN A 1 286 ? -8.676  -16.269 -29.132 1.00 46.42  ? 549  ASN A OD1 1 
ATOM   1965 N  ND2 . ASN A 1 286 ? -7.349  -17.778 -28.170 1.00 47.79  ? 549  ASN A ND2 1 
ATOM   1966 N  N   . GLU A 1 287 ? -12.568 -18.987 -26.984 1.00 28.24  ? 550  GLU A N   1 
ATOM   1967 C  CA  . GLU A 1 287 ? -13.839 -19.772 -26.858 1.00 35.39  ? 550  GLU A CA  1 
ATOM   1968 C  C   . GLU A 1 287 ? -15.088 -18.858 -27.020 1.00 36.28  ? 550  GLU A C   1 
ATOM   1969 O  O   . GLU A 1 287 ? -16.051 -19.263 -27.703 1.00 33.48  ? 550  GLU A O   1 
ATOM   1970 C  CB  . GLU A 1 287 ? -13.819 -20.502 -25.518 1.00 30.85  ? 550  GLU A CB  1 
ATOM   1971 C  CG  . GLU A 1 287 ? -12.858 -21.674 -25.534 1.00 33.14  ? 550  GLU A CG  1 
ATOM   1972 C  CD  . GLU A 1 287 ? -12.536 -22.229 -24.165 1.00 37.59  ? 550  GLU A CD  1 
ATOM   1973 O  OE1 . GLU A 1 287 ? -13.266 -21.887 -23.186 1.00 40.99  ? 550  GLU A OE1 1 
ATOM   1974 O  OE2 . GLU A 1 287 ? -11.571 -23.025 -24.070 1.00 40.97  ? 550  GLU A OE2 1 
ATOM   1975 N  N   A GLU A 1 288 ? -15.061 -17.653 -26.439 0.25 36.81  ? 551  GLU A N   1 
ATOM   1976 N  N   B GLU A 1 288 ? -15.035 -17.654 -26.439 0.25 35.45  ? 551  GLU A N   1 
ATOM   1977 C  CA  A GLU A 1 288 ? -16.206 -16.699 -26.495 0.25 37.96  ? 551  GLU A CA  1 
ATOM   1978 C  CA  B GLU A 1 288 ? -16.129 -16.640 -26.469 0.25 35.88  ? 551  GLU A CA  1 
ATOM   1979 C  C   A GLU A 1 288 ? -16.507 -16.299 -27.944 0.25 37.68  ? 551  GLU A C   1 
ATOM   1980 C  C   B GLU A 1 288 ? -16.476 -16.262 -27.915 0.25 36.44  ? 551  GLU A C   1 
ATOM   1981 O  O   A GLU A 1 288 ? -17.670 -15.909 -28.212 0.25 40.74  ? 551  GLU A O   1 
ATOM   1982 O  O   B GLU A 1 288 ? -17.640 -15.859 -28.151 0.25 40.12  ? 551  GLU A O   1 
ATOM   1983 C  CB  A GLU A 1 288 ? -15.956 -15.439 -25.665 0.25 41.73  ? 551  GLU A CB  1 
ATOM   1984 C  CB  B GLU A 1 288 ? -15.723 -15.410 -25.651 0.25 37.44  ? 551  GLU A CB  1 
ATOM   1985 C  CG  A GLU A 1 288 ? -17.158 -14.503 -25.658 0.25 44.76  ? 551  GLU A CG  1 
ATOM   1986 C  CG  B GLU A 1 288 ? -16.881 -14.479 -25.318 0.25 38.58  ? 551  GLU A CG  1 
ATOM   1987 C  CD  A GLU A 1 288 ? -16.961 -13.177 -24.942 0.25 47.51  ? 551  GLU A CD  1 
ATOM   1988 C  CD  B GLU A 1 288 ? -17.217 -13.453 -26.391 0.25 40.38  ? 551  GLU A CD  1 
ATOM   1989 O  OE1 A GLU A 1 288 ? -15.806 -12.900 -24.550 0.25 50.08  ? 551  GLU A OE1 1 
ATOM   1990 O  OE1 B GLU A 1 288 ? -16.339 -13.176 -27.225 0.25 38.17  ? 551  GLU A OE1 1 
ATOM   1991 O  OE2 A GLU A 1 288 ? -17.970 -12.423 -24.769 0.25 47.59  ? 551  GLU A OE2 1 
ATOM   1992 O  OE2 B GLU A 1 288 ? -18.357 -12.926 -26.380 0.25 42.90  ? 551  GLU A OE2 1 
ATOM   1993 N  N   . MET A 1 289 ? -15.535 -16.409 -28.854 1.00 34.51  ? 552  MET A N   1 
ATOM   1994 C  CA  . MET A 1 289 ? -15.764 -16.042 -30.276 1.00 35.72  ? 552  MET A CA  1 
ATOM   1995 C  C   . MET A 1 289 ? -16.865 -16.884 -30.930 1.00 37.14  ? 552  MET A C   1 
ATOM   1996 O  O   . MET A 1 289 ? -17.353 -16.499 -32.068 1.00 38.18  ? 552  MET A O   1 
ATOM   1997 C  CB  . MET A 1 289 ? -14.477 -16.124 -31.110 1.00 37.65  ? 552  MET A CB  1 
ATOM   1998 C  CG  . MET A 1 289 ? -13.419 -15.140 -30.604 1.00 44.86  ? 552  MET A CG  1 
ATOM   1999 S  SD  . MET A 1 289 ? -12.164 -14.692 -31.887 1.00 52.64  ? 552  MET A SD  1 
ATOM   2000 C  CE  . MET A 1 289 ? -11.482 -16.295 -32.254 1.00 44.83  ? 552  MET A CE  1 
ATOM   2001 N  N   . VAL A 1 290 ? -17.332 -17.978 -30.312 1.00 34.00  ? 553  VAL A N   1 
ATOM   2002 C  CA  . VAL A 1 290 ? -18.531 -18.660 -30.893 1.00 35.40  ? 553  VAL A CA  1 
ATOM   2003 C  C   . VAL A 1 290 ? -19.706 -17.650 -30.964 1.00 31.65  ? 553  VAL A C   1 
ATOM   2004 O  O   . VAL A 1 290 ? -20.547 -17.810 -31.866 1.00 44.54  ? 553  VAL A O   1 
ATOM   2005 C  CB  . VAL A 1 290 ? -18.916 -19.930 -30.115 1.00 31.04  ? 553  VAL A CB  1 
ATOM   2006 C  CG1 . VAL A 1 290 ? -19.324 -19.630 -28.680 1.00 30.34  ? 553  VAL A CG1 1 
ATOM   2007 C  CG2 . VAL A 1 290 ? -20.019 -20.681 -30.816 1.00 30.96  ? 553  VAL A CG2 1 
ATOM   2008 N  N   . THR A 1 291 ? -19.802 -16.689 -30.048 1.00 33.52  ? 554  THR A N   1 
ATOM   2009 C  CA  . THR A 1 291 ? -20.886 -15.635 -30.024 1.00 37.87  ? 554  THR A CA  1 
ATOM   2010 C  C   . THR A 1 291 ? -20.874 -14.742 -31.279 1.00 38.91  ? 554  THR A C   1 
ATOM   2011 O  O   . THR A 1 291 ? -21.957 -14.156 -31.601 1.00 42.42  ? 554  THR A O   1 
ATOM   2012 C  CB  . THR A 1 291 ? -20.761 -14.645 -28.871 1.00 32.94  ? 554  THR A CB  1 
ATOM   2013 O  OG1 . THR A 1 291 ? -19.474 -14.030 -29.012 1.00 36.38  ? 554  THR A OG1 1 
ATOM   2014 C  CG2 . THR A 1 291 ? -20.926 -15.268 -27.514 1.00 32.62  ? 554  THR A CG2 1 
ATOM   2015 N  N   . ASN A 1 292 ? -19.731 -14.628 -31.958 1.00 39.88  ? 555  ASN A N   1 
ATOM   2016 C  CA  . ASN A 1 292 ? -19.627 -13.937 -33.278 1.00 42.62  ? 555  ASN A CA  1 
ATOM   2017 C  C   . ASN A 1 292 ? -20.556 -14.575 -34.314 1.00 46.91  ? 555  ASN A C   1 
ATOM   2018 O  O   . ASN A 1 292 ? -20.710 -13.977 -35.398 1.00 48.90  ? 555  ASN A O   1 
ATOM   2019 C  CB  . ASN A 1 292 ? -18.228 -13.961 -33.895 1.00 40.08  ? 555  ASN A CB  1 
ATOM   2020 C  CG  . ASN A 1 292 ? -17.219 -13.229 -33.045 1.00 40.77  ? 555  ASN A CG  1 
ATOM   2021 O  OD1 . ASN A 1 292 ? -17.580 -12.614 -32.042 1.00 45.03  ? 555  ASN A OD1 1 
ATOM   2022 N  ND2 . ASN A 1 292 ? -15.952 -13.365 -33.390 1.00 42.33  ? 555  ASN A ND2 1 
ATOM   2023 N  N   . HIS A 1 293 ? -21.057 -15.786 -34.057 1.00 40.11  ? 556  HIS A N   1 
ATOM   2024 C  CA  . HIS A 1 293 ? -21.868 -16.580 -35.017 1.00 45.39  ? 556  HIS A CA  1 
ATOM   2025 C  C   . HIS A 1 293 ? -23.351 -16.527 -34.632 1.00 36.86  ? 556  HIS A C   1 
ATOM   2026 O  O   . HIS A 1 293 ? -24.155 -17.214 -35.277 1.00 40.96  ? 556  HIS A O   1 
ATOM   2027 C  CB  . HIS A 1 293 ? -21.293 -18.005 -35.121 1.00 41.04  ? 556  HIS A CB  1 
ATOM   2028 C  CG  . HIS A 1 293 ? -19.914 -17.998 -35.701 1.00 45.07  ? 556  HIS A CG  1 
ATOM   2029 N  ND1 . HIS A 1 293 ? -19.690 -18.156 -37.051 1.00 47.82  ? 556  HIS A ND1 1 
ATOM   2030 C  CD2 . HIS A 1 293 ? -18.691 -17.859 -35.130 1.00 47.11  ? 556  HIS A CD2 1 
ATOM   2031 C  CE1 . HIS A 1 293 ? -18.394 -18.082 -37.297 1.00 45.50  ? 556  HIS A CE1 1 
ATOM   2032 N  NE2 . HIS A 1 293 ? -17.760 -17.891 -36.145 1.00 42.17  ? 556  HIS A NE2 1 
ATOM   2033 N  N   . MET A 1 294 ? -23.673 -15.796 -33.567 1.00 39.68  ? 557  MET A N   1 
ATOM   2034 C  CA  . MET A 1 294 ? -25.017 -15.764 -32.957 1.00 36.90  ? 557  MET A CA  1 
ATOM   2035 C  C   . MET A 1 294 ? -25.707 -14.444 -33.331 1.00 45.42  ? 557  MET A C   1 
ATOM   2036 O  O   . MET A 1 294 ? -25.054 -13.591 -33.882 1.00 40.38  ? 557  MET A O   1 
ATOM   2037 C  CB  . MET A 1 294 ? -24.904 -15.844 -31.440 1.00 40.78  ? 557  MET A CB  1 
ATOM   2038 C  CG  . MET A 1 294 ? -24.355 -17.194 -30.964 1.00 40.51  ? 557  MET A CG  1 
ATOM   2039 S  SD  . MET A 1 294 ? -24.263 -17.212 -29.192 1.00 37.63  ? 557  MET A SD  1 
ATOM   2040 C  CE  . MET A 1 294 ? -23.309 -18.725 -28.976 1.00 42.39  ? 557  MET A CE  1 
ATOM   2041 N  N   . GLU A 1 295 ? -26.976 -14.287 -32.974 1.00 51.28  ? 558  GLU A N   1 
ATOM   2042 C  CA  . GLU A 1 295 ? -27.729 -13.028 -33.208 1.00 51.09  ? 558  GLU A CA  1 
ATOM   2043 C  C   . GLU A 1 295 ? -28.812 -12.867 -32.155 1.00 48.88  ? 558  GLU A C   1 
ATOM   2044 O  O   . GLU A 1 295 ? -29.168 -13.874 -31.508 1.00 50.28  ? 558  GLU A O   1 
ATOM   2045 C  CB  . GLU A 1 295 ? -28.331 -13.075 -34.603 1.00 48.68  ? 558  GLU A CB  1 
ATOM   2046 C  CG  . GLU A 1 295 ? -29.428 -14.085 -34.760 1.00 48.03  ? 558  GLU A CG  1 
ATOM   2047 C  CD  . GLU A 1 295 ? -29.829 -14.300 -36.208 1.00 70.83  ? 558  GLU A CD  1 
ATOM   2048 O  OE1 . GLU A 1 295 ? -28.934 -14.269 -37.126 1.00 74.69  ? 558  GLU A OE1 1 
ATOM   2049 O  OE2 . GLU A 1 295 ? -31.042 -14.484 -36.423 1.00 70.43  ? 558  GLU A OE2 1 
ATOM   2050 N  N   . GLY A 1 296 ? -29.351 -11.647 -32.054 1.00 58.51  ? 559  GLY A N   1 
ATOM   2051 C  CA  . GLY A 1 296 ? -30.530 -11.331 -31.231 1.00 50.38  ? 559  GLY A CA  1 
ATOM   2052 C  C   . GLY A 1 296 ? -30.240 -11.531 -29.758 1.00 52.73  ? 559  GLY A C   1 
ATOM   2053 O  O   . GLY A 1 296 ? -29.058 -11.278 -29.349 1.00 52.00  ? 559  GLY A O   1 
ATOM   2054 N  N   . GLU A 1 297 ? -31.263 -12.003 -29.029 1.00 47.04  ? 560  GLU A N   1 
ATOM   2055 C  CA  . GLU A 1 297 ? -31.229 -12.391 -27.599 1.00 55.67  ? 560  GLU A CA  1 
ATOM   2056 C  C   . GLU A 1 297 ? -30.046 -13.351 -27.373 1.00 57.32  ? 560  GLU A C   1 
ATOM   2057 O  O   . GLU A 1 297 ? -29.159 -13.036 -26.566 1.00 59.39  ? 560  GLU A O   1 
ATOM   2058 C  CB  . GLU A 1 297 ? -32.554 -13.059 -27.217 1.00 60.39  ? 560  GLU A CB  1 
ATOM   2059 C  CG  . GLU A 1 297 ? -33.117 -12.585 -25.893 1.00 68.97  ? 560  GLU A CG  1 
ATOM   2060 C  CD  . GLU A 1 297 ? -34.554 -12.989 -25.620 1.00 79.36  ? 560  GLU A CD  1 
ATOM   2061 O  OE1 . GLU A 1 297 ? -34.824 -14.205 -25.624 1.00 77.67  ? 560  GLU A OE1 1 
ATOM   2062 O  OE2 . GLU A 1 297 ? -35.400 -12.084 -25.396 1.00 89.26  ? 560  GLU A OE2 1 
ATOM   2063 N  N   . HIS A 1 298 ? -30.029 -14.467 -28.093 1.00 54.64  ? 561  HIS A N   1 
ATOM   2064 C  CA  . HIS A 1 298 ? -29.023 -15.556 -27.945 1.00 49.92  ? 561  HIS A CA  1 
ATOM   2065 C  C   . HIS A 1 298 ? -27.617 -14.954 -27.833 1.00 45.21  ? 561  HIS A C   1 
ATOM   2066 O  O   . HIS A 1 298 ? -26.950 -15.233 -26.833 1.00 52.43  ? 561  HIS A O   1 
ATOM   2067 C  CB  . HIS A 1 298 ? -29.136 -16.561 -29.081 1.00 49.24  ? 561  HIS A CB  1 
ATOM   2068 C  CG  . HIS A 1 298 ? -28.241 -17.739 -28.884 1.00 48.00  ? 561  HIS A CG  1 
ATOM   2069 N  ND1 . HIS A 1 298 ? -27.836 -18.537 -29.935 1.00 45.57  ? 561  HIS A ND1 1 
ATOM   2070 C  CD2 . HIS A 1 298 ? -27.672 -18.239 -27.762 1.00 43.37  ? 561  HIS A CD2 1 
ATOM   2071 C  CE1 . HIS A 1 298 ? -27.067 -19.495 -29.459 1.00 49.31  ? 561  HIS A CE1 1 
ATOM   2072 N  NE2 . HIS A 1 298 ? -26.951 -19.330 -28.132 1.00 45.68  ? 561  HIS A NE2 1 
ATOM   2073 N  N   . LYS A 1 299 ? -27.223 -14.083 -28.760 1.00 42.81  ? 562  LYS A N   1 
ATOM   2074 C  CA  . LYS A 1 299 ? -25.882 -13.465 -28.759 1.00 46.62  ? 562  LYS A CA  1 
ATOM   2075 C  C   . LYS A 1 299 ? -25.625 -12.798 -27.407 1.00 58.12  ? 562  LYS A C   1 
ATOM   2076 O  O   . LYS A 1 299 ? -24.506 -12.958 -26.883 1.00 61.88  ? 562  LYS A O   1 
ATOM   2077 C  CB  . LYS A 1 299 ? -25.680 -12.496 -29.918 1.00 48.26  ? 562  LYS A CB  1 
ATOM   2078 C  CG  . LYS A 1 299 ? -24.352 -11.748 -29.862 1.00 44.03  ? 562  LYS A CG  1 
ATOM   2079 C  CD  . LYS A 1 299 ? -23.891 -11.278 -31.198 1.00 47.14  ? 562  LYS A CD  1 
ATOM   2080 C  CE  . LYS A 1 299 ? -22.840 -10.197 -31.153 1.00 50.38  ? 562  LYS A CE  1 
ATOM   2081 N  NZ  . LYS A 1 299 ? -21.770 -10.476 -32.133 1.00 57.50  ? 562  LYS A NZ  1 
ATOM   2082 N  N   . LYS A 1 300 ? -26.617 -12.101 -26.851 1.00 62.84  ? 563  LYS A N   1 
ATOM   2083 C  CA  . LYS A 1 300 ? -26.452 -11.322 -25.592 1.00 61.66  ? 563  LYS A CA  1 
ATOM   2084 C  C   . LYS A 1 300 ? -26.398 -12.283 -24.415 1.00 48.44  ? 563  LYS A C   1 
ATOM   2085 O  O   . LYS A 1 300 ? -25.554 -12.104 -23.554 1.00 52.49  ? 563  LYS A O   1 
ATOM   2086 C  CB  . LYS A 1 300 ? -27.621 -10.355 -25.345 1.00 70.47  ? 563  LYS A CB  1 
ATOM   2087 C  CG  . LYS A 1 300 ? -27.671 -9.142  -26.267 1.00 74.95  ? 563  LYS A CG  1 
ATOM   2088 C  CD  . LYS A 1 300 ? -26.430 -8.270  -26.231 1.00 73.60  ? 563  LYS A CD  1 
ATOM   2089 C  CE  . LYS A 1 300 ? -26.000 -7.789  -27.600 1.00 79.12  ? 563  LYS A CE  1 
ATOM   2090 N  NZ  . LYS A 1 300 ? -25.310 -6.477  -27.518 1.00 86.16  ? 563  LYS A NZ  1 
ATOM   2091 N  N   . LEU A 1 301 ? -27.312 -13.249 -24.390 1.00 48.18  ? 564  LEU A N   1 
ATOM   2092 C  CA  . LEU A 1 301 ? -27.373 -14.283 -23.332 1.00 48.70  ? 564  LEU A CA  1 
ATOM   2093 C  C   . LEU A 1 301 ? -26.035 -15.072 -23.275 1.00 50.98  ? 564  LEU A C   1 
ATOM   2094 O  O   . LEU A 1 301 ? -25.548 -15.315 -22.151 1.00 45.11  ? 564  LEU A O   1 
ATOM   2095 C  CB  . LEU A 1 301 ? -28.595 -15.170 -23.606 1.00 52.21  ? 564  LEU A CB  1 
ATOM   2096 C  CG  . LEU A 1 301 ? -29.971 -14.534 -23.314 1.00 49.50  ? 564  LEU A CG  1 
ATOM   2097 C  CD1 . LEU A 1 301 ? -31.079 -15.505 -23.633 1.00 48.13  ? 564  LEU A CD1 1 
ATOM   2098 C  CD2 . LEU A 1 301 ? -30.091 -14.104 -21.852 1.00 52.24  ? 564  LEU A CD2 1 
ATOM   2099 N  N   . ALA A 1 302 ? -25.453 -15.444 -24.423 1.00 46.66  ? 565  ALA A N   1 
ATOM   2100 C  CA  . ALA A 1 302 ? -24.199 -16.236 -24.515 1.00 47.41  ? 565  ALA A CA  1 
ATOM   2101 C  C   . ALA A 1 302 ? -23.039 -15.356 -24.047 1.00 49.45  ? 565  ALA A C   1 
ATOM   2102 O  O   . ALA A 1 302 ? -22.230 -15.838 -23.241 1.00 45.67  ? 565  ALA A O   1 
ATOM   2103 C  CB  . ALA A 1 302 ? -23.978 -16.758 -25.922 1.00 44.32  ? 565  ALA A CB  1 
ATOM   2104 N  N   . GLU A 1 303 ? -22.979 -14.108 -24.527 1.00 45.92  ? 566  GLU A N   1 
ATOM   2105 C  CA  . GLU A 1 303 ? -21.922 -13.123 -24.160 1.00 47.26  ? 566  GLU A CA  1 
ATOM   2106 C  C   . GLU A 1 303 ? -21.861 -12.926 -22.643 1.00 42.85  ? 566  GLU A C   1 
ATOM   2107 O  O   . GLU A 1 303 ? -20.755 -12.756 -22.129 1.00 45.26  ? 566  GLU A O   1 
ATOM   2108 C  CB  . GLU A 1 303 ? -22.162 -11.774 -24.822 1.00 53.42  ? 566  GLU A CB  1 
ATOM   2109 C  CG  . GLU A 1 303 ? -21.753 -11.776 -26.263 1.00 58.30  ? 566  GLU A CG  1 
ATOM   2110 C  CD  . GLU A 1 303 ? -22.073 -10.490 -26.989 1.00 61.11  ? 566  GLU A CD  1 
ATOM   2111 O  OE1 . GLU A 1 303 ? -22.375 -9.508  -26.309 1.00 74.37  ? 566  GLU A OE1 1 
ATOM   2112 O  OE2 . GLU A 1 303 ? -21.968 -10.480 -28.240 1.00 63.60  ? 566  GLU A OE2 1 
ATOM   2113 N  N   . ALA A 1 304 ? -22.998 -13.006 -21.956 1.00 42.45  ? 567  ALA A N   1 
ATOM   2114 C  CA  . ALA A 1 304 ? -23.094 -12.800 -20.496 1.00 48.85  ? 567  ALA A CA  1 
ATOM   2115 C  C   . ALA A 1 304 ? -22.615 -14.059 -19.764 1.00 45.77  ? 567  ALA A C   1 
ATOM   2116 O  O   . ALA A 1 304 ? -21.947 -13.899 -18.727 1.00 44.32  ? 567  ALA A O   1 
ATOM   2117 C  CB  . ALA A 1 304 ? -24.509 -12.428 -20.095 1.00 51.13  ? 567  ALA A CB  1 
ATOM   2118 N  N   . ILE A 1 305 ? -22.996 -15.256 -20.223 1.00 45.09  ? 568  ILE A N   1 
ATOM   2119 C  CA  . ILE A 1 305 ? -22.424 -16.505 -19.647 1.00 45.76  ? 568  ILE A CA  1 
ATOM   2120 C  C   . ILE A 1 305 ? -20.886 -16.370 -19.679 1.00 42.22  ? 568  ILE A C   1 
ATOM   2121 O  O   . ILE A 1 305 ? -20.268 -16.451 -18.617 1.00 41.88  ? 568  ILE A O   1 
ATOM   2122 C  CB  . ILE A 1 305 ? -22.931 -17.782 -20.349 1.00 49.36  ? 568  ILE A CB  1 
ATOM   2123 C  CG1 . ILE A 1 305 ? -24.440 -17.996 -20.160 1.00 48.25  ? 568  ILE A CG1 1 
ATOM   2124 C  CG2 . ILE A 1 305 ? -22.130 -19.001 -19.867 1.00 47.73  ? 568  ILE A CG2 1 
ATOM   2125 C  CD1 . ILE A 1 305 ? -24.899 -17.948 -18.718 1.00 44.32  ? 568  ILE A CD1 1 
ATOM   2126 N  N   . PHE A 1 306 ? -20.285 -16.075 -20.835 1.00 39.84  ? 569  PHE A N   1 
ATOM   2127 C  CA  . PHE A 1 306 ? -18.812 -16.024 -21.004 1.00 40.44  ? 569  PHE A CA  1 
ATOM   2128 C  C   . PHE A 1 306 ? -18.222 -14.910 -20.129 1.00 46.70  ? 569  PHE A C   1 
ATOM   2129 O  O   . PHE A 1 306 ? -17.253 -15.212 -19.438 1.00 44.25  ? 569  PHE A O   1 
ATOM   2130 C  CB  . PHE A 1 306 ? -18.404 -15.834 -22.466 1.00 44.50  ? 569  PHE A CB  1 
ATOM   2131 C  CG  . PHE A 1 306 ? -18.405 -17.097 -23.287 1.00 47.07  ? 569  PHE A CG  1 
ATOM   2132 C  CD1 . PHE A 1 306 ? -17.407 -18.042 -23.128 1.00 48.93  ? 569  PHE A CD1 1 
ATOM   2133 C  CD2 . PHE A 1 306 ? -19.353 -17.310 -24.271 1.00 45.62  ? 569  PHE A CD2 1 
ATOM   2134 C  CE1 . PHE A 1 306 ? -17.399 -19.193 -23.897 1.00 46.74  ? 569  PHE A CE1 1 
ATOM   2135 C  CE2 . PHE A 1 306 ? -19.345 -18.460 -25.044 1.00 45.16  ? 569  PHE A CE2 1 
ATOM   2136 C  CZ  . PHE A 1 306 ? -18.387 -19.417 -24.826 1.00 47.23  ? 569  PHE A CZ  1 
ATOM   2137 N  N   . LYS A 1 307 ? -18.767 -13.682 -20.159 1.00 48.39  ? 570  LYS A N   1 
ATOM   2138 C  CA  . LYS A 1 307 ? -18.251 -12.508 -19.392 1.00 50.29  ? 570  LYS A CA  1 
ATOM   2139 C  C   . LYS A 1 307 ? -18.453 -12.703 -17.893 1.00 45.68  ? 570  LYS A C   1 
ATOM   2140 O  O   . LYS A 1 307 ? -17.507 -12.499 -17.167 1.00 46.73  ? 570  LYS A O   1 
ATOM   2141 C  CB  . LYS A 1 307 ? -18.966 -11.190 -19.727 1.00 65.08  ? 570  LYS A CB  1 
ATOM   2142 C  CG  . LYS A 1 307 ? -18.393 -10.411 -20.898 1.00 73.18  ? 570  LYS A CG  1 
ATOM   2143 C  CD  . LYS A 1 307 ? -19.064 -9.058  -21.112 1.00 92.30  ? 570  LYS A CD  1 
ATOM   2144 C  CE  . LYS A 1 307 ? -18.550 -8.314  -22.331 1.00 99.18  ? 570  LYS A CE  1 
ATOM   2145 N  NZ  . LYS A 1 307 ? -18.524 -9.178  -23.541 1.00 98.47  ? 570  LYS A NZ  1 
ATOM   2146 N  N   . LEU A 1 308 ? -19.651 -13.082 -17.455 1.00 44.02  ? 571  LEU A N   1 
ATOM   2147 C  CA  . LEU A 1 308 ? -20.034 -12.939 -16.030 1.00 47.08  ? 571  LEU A CA  1 
ATOM   2148 C  C   . LEU A 1 308 ? -19.733 -14.199 -15.232 1.00 48.73  ? 571  LEU A C   1 
ATOM   2149 O  O   . LEU A 1 308 ? -19.489 -14.050 -14.003 1.00 53.69  ? 571  LEU A O   1 
ATOM   2150 C  CB  . LEU A 1 308 ? -21.521 -12.555 -15.948 1.00 48.02  ? 571  LEU A CB  1 
ATOM   2151 C  CG  . LEU A 1 308 ? -21.848 -11.261 -16.706 1.00 52.01  ? 571  LEU A CG  1 
ATOM   2152 C  CD1 . LEU A 1 308 ? -23.351 -11.037 -16.814 1.00 53.73  ? 571  LEU A CD1 1 
ATOM   2153 C  CD2 . LEU A 1 308 ? -21.154 -10.065 -16.082 1.00 49.56  ? 571  LEU A CD2 1 
ATOM   2154 N  N   . THR A 1 309 ? -19.827 -15.388 -15.833 1.00 44.76  ? 572  THR A N   1 
ATOM   2155 C  CA  . THR A 1 309 ? -19.661 -16.669 -15.101 1.00 46.87  ? 572  THR A CA  1 
ATOM   2156 C  C   . THR A 1 309 ? -18.370 -17.414 -15.500 1.00 44.66  ? 572  THR A C   1 
ATOM   2157 O  O   . THR A 1 309 ? -17.885 -18.148 -14.684 1.00 46.10  ? 572  THR A O   1 
ATOM   2158 C  CB  . THR A 1 309 ? -20.900 -17.543 -15.285 1.00 52.69  ? 572  THR A CB  1 
ATOM   2159 O  OG1 . THR A 1 309 ? -20.947 -17.875 -16.672 1.00 49.75  ? 572  THR A OG1 1 
ATOM   2160 C  CG2 . THR A 1 309 ? -22.171 -16.833 -14.885 1.00 61.13  ? 572  THR A CG2 1 
ATOM   2161 N  N   . TYR A 1 310 ? -17.828 -17.263 -16.701 1.00 47.25  ? 573  TYR A N   1 
ATOM   2162 C  CA  . TYR A 1 310 ? -16.631 -18.048 -17.134 1.00 50.87  ? 573  TYR A CA  1 
ATOM   2163 C  C   . TYR A 1 310 ? -15.370 -17.201 -16.925 1.00 50.13  ? 573  TYR A C   1 
ATOM   2164 O  O   . TYR A 1 310 ? -14.439 -17.715 -16.280 1.00 54.00  ? 573  TYR A O   1 
ATOM   2165 C  CB  . TYR A 1 310 ? -16.748 -18.552 -18.584 1.00 42.58  ? 573  TYR A CB  1 
ATOM   2166 C  CG  . TYR A 1 310 ? -17.755 -19.651 -18.848 1.00 37.22  ? 573  TYR A CG  1 
ATOM   2167 C  CD1 . TYR A 1 310 ? -18.578 -20.138 -17.866 1.00 36.58  ? 573  TYR A CD1 1 
ATOM   2168 C  CD2 . TYR A 1 310 ? -17.972 -20.105 -20.137 1.00 37.20  ? 573  TYR A CD2 1 
ATOM   2169 C  CE1 . TYR A 1 310 ? -19.517 -21.121 -18.123 1.00 38.90  ? 573  TYR A CE1 1 
ATOM   2170 C  CE2 . TYR A 1 310 ? -18.942 -21.044 -20.422 1.00 36.21  ? 573  TYR A CE2 1 
ATOM   2171 C  CZ  . TYR A 1 310 ? -19.689 -21.587 -19.407 1.00 36.38  ? 573  TYR A CZ  1 
ATOM   2172 O  OH  . TYR A 1 310 ? -20.660 -22.505 -19.675 1.00 42.58  ? 573  TYR A OH  1 
ATOM   2173 N  N   . GLN A 1 311 ? -15.353 -15.961 -17.442 1.00 44.22  ? 574  GLN A N   1 
ATOM   2174 C  CA  . GLN A 1 311 ? -14.193 -15.040 -17.387 1.00 43.17  ? 574  GLN A CA  1 
ATOM   2175 C  C   . GLN A 1 311 ? -14.115 -14.252 -16.062 1.00 48.82  ? 574  GLN A C   1 
ATOM   2176 O  O   . GLN A 1 311 ? -13.149 -13.495 -15.890 1.00 45.67  ? 574  GLN A O   1 
ATOM   2177 C  CB  . GLN A 1 311 ? -14.206 -14.104 -18.581 1.00 44.61  ? 574  GLN A CB  1 
ATOM   2178 C  CG  . GLN A 1 311 ? -14.063 -14.840 -19.897 1.00 43.92  ? 574  GLN A CG  1 
ATOM   2179 C  CD  . GLN A 1 311 ? -14.158 -13.888 -21.056 1.00 43.16  ? 574  GLN A CD  1 
ATOM   2180 O  OE1 . GLN A 1 311 ? -13.978 -12.694 -20.916 1.00 61.71  ? 574  GLN A OE1 1 
ATOM   2181 N  NE2 . GLN A 1 311 ? -14.392 -14.421 -22.231 1.00 53.57  ? 574  GLN A NE2 1 
ATOM   2182 N  N   . ASN A 1 312 ? -15.034 -14.475 -15.106 0.50 49.42  ? 575  ASN A N   1 
ATOM   2183 C  CA  . ASN A 1 312 ? -15.060 -13.763 -13.792 0.50 50.68  ? 575  ASN A CA  1 
ATOM   2184 C  C   . ASN A 1 312 ? -15.916 -14.531 -12.769 0.50 50.94  ? 575  ASN A C   1 
ATOM   2185 O  O   . ASN A 1 312 ? -17.060 -14.105 -12.533 0.50 55.18  ? 575  ASN A O   1 
ATOM   2186 C  CB  . ASN A 1 312 ? -15.610 -12.336 -13.936 0.50 50.20  ? 575  ASN A CB  1 
ATOM   2187 C  CG  . ASN A 1 312 ? -14.592 -11.323 -14.419 0.50 51.67  ? 575  ASN A CG  1 
ATOM   2188 O  OD1 . ASN A 1 312 ? -13.754 -10.868 -13.647 0.50 57.75  ? 575  ASN A OD1 1 
ATOM   2189 N  ND2 . ASN A 1 312 ? -14.666 -10.944 -15.687 0.50 51.10  ? 575  ASN A ND2 1 
ATOM   2190 N  N   . LYS A 1 313 ? -15.376 -15.576 -12.133 0.50 52.44  ? 576  LYS A N   1 
ATOM   2191 C  CA  . LYS A 1 313 ? -16.159 -16.556 -11.327 0.50 53.43  ? 576  LYS A CA  1 
ATOM   2192 C  C   . LYS A 1 313 ? -16.193 -16.155 -9.846  0.50 55.98  ? 576  LYS A C   1 
ATOM   2193 O  O   . LYS A 1 313 ? -15.308 -15.393 -9.424  0.50 59.67  ? 576  LYS A O   1 
ATOM   2194 C  CB  . LYS A 1 313 ? -15.554 -17.960 -11.414 0.50 55.05  ? 576  LYS A CB  1 
ATOM   2195 C  CG  . LYS A 1 313 ? -14.862 -18.297 -12.725 0.50 56.64  ? 576  LYS A CG  1 
ATOM   2196 C  CD  . LYS A 1 313 ? -14.031 -19.559 -12.650 0.50 57.82  ? 576  LYS A CD  1 
ATOM   2197 C  CE  . LYS A 1 313 ? -13.140 -19.725 -13.859 0.50 58.19  ? 576  LYS A CE  1 
ATOM   2198 N  NZ  . LYS A 1 313 ? -12.520 -18.436 -14.248 0.50 59.92  ? 576  LYS A NZ  1 
ATOM   2199 N  N   . VAL A 1 314 ? -17.174 -16.691 -9.108  1.00 51.29  ? 577  VAL A N   1 
ATOM   2200 C  CA  . VAL A 1 314 ? -17.339 -16.535 -7.648  1.00 52.45  ? 577  VAL A CA  1 
ATOM   2201 C  C   . VAL A 1 314 ? -17.585 -17.947 -7.153  1.00 48.92  ? 577  VAL A C   1 
ATOM   2202 O  O   . VAL A 1 314 ? -18.454 -18.616 -7.708  1.00 44.66  ? 577  VAL A O   1 
ATOM   2203 C  CB  . VAL A 1 314 ? -18.524 -15.608 -7.315  1.00 59.37  ? 577  VAL A CB  1 
ATOM   2204 C  CG1 . VAL A 1 314 ? -18.901 -15.690 -5.838  1.00 59.21  ? 577  VAL A CG1 1 
ATOM   2205 C  CG2 . VAL A 1 314 ? -18.259 -14.173 -7.760  1.00 51.59  ? 577  VAL A CG2 1 
ATOM   2206 N  N   . VAL A 1 315 ? -16.856 -18.383 -6.138  1.00 47.30  ? 578  VAL A N   1 
ATOM   2207 C  CA  . VAL A 1 315 ? -16.875 -19.807 -5.713  1.00 49.78  ? 578  VAL A CA  1 
ATOM   2208 C  C   . VAL A 1 315 ? -16.981 -19.873 -4.199  1.00 49.19  ? 578  VAL A C   1 
ATOM   2209 O  O   . VAL A 1 315 ? -16.389 -19.020 -3.533  1.00 50.83  ? 578  VAL A O   1 
ATOM   2210 C  CB  . VAL A 1 315 ? -15.597 -20.501 -6.211  1.00 54.37  ? 578  VAL A CB  1 
ATOM   2211 C  CG1 . VAL A 1 315 ? -15.615 -21.983 -5.897  1.00 56.33  ? 578  VAL A CG1 1 
ATOM   2212 C  CG2 . VAL A 1 315 ? -15.377 -20.251 -7.698  1.00 57.07  ? 578  VAL A CG2 1 
ATOM   2213 N  N   . ARG A 1 316 ? -17.626 -20.908 -3.694  1.00 55.00  ? 579  ARG A N   1 
ATOM   2214 C  CA  . ARG A 1 316 ? -17.736 -21.135 -2.241  1.00 64.91  ? 579  ARG A CA  1 
ATOM   2215 C  C   . ARG A 1 316 ? -17.133 -22.518 -1.920  1.00 69.38  ? 579  ARG A C   1 
ATOM   2216 O  O   . ARG A 1 316 ? -17.570 -23.525 -2.499  1.00 72.65  ? 579  ARG A O   1 
ATOM   2217 C  CB  . ARG A 1 316 ? -19.182 -20.855 -1.843  1.00 69.26  ? 579  ARG A CB  1 
ATOM   2218 C  CG  . ARG A 1 316 ? -20.208 -21.768 -2.476  1.00 77.99  ? 579  ARG A CG  1 
ATOM   2219 C  CD  . ARG A 1 316 ? -21.517 -21.624 -1.731  1.00 89.62  ? 579  ARG A CD  1 
ATOM   2220 N  NE  . ARG A 1 316 ? -22.117 -20.308 -1.869  1.00 90.90  ? 579  ARG A NE  1 
ATOM   2221 C  CZ  . ARG A 1 316 ? -23.368 -20.026 -1.542  1.00 95.10  ? 579  ARG A CZ  1 
ATOM   2222 N  NH1 . ARG A 1 316 ? -23.822 -18.796 -1.701  1.00 104.84 ? 579  ARG A NH1 1 
ATOM   2223 N  NH2 . ARG A 1 316 ? -24.162 -20.970 -1.062  1.00 93.01  ? 579  ARG A NH2 1 
ATOM   2224 N  N   . VAL A 1 317 ? -16.135 -22.543 -1.030  0.50 67.77  ? 580  VAL A N   1 
ATOM   2225 C  CA  . VAL A 1 317 ? -15.325 -23.750 -0.685  0.50 67.42  ? 580  VAL A CA  1 
ATOM   2226 C  C   . VAL A 1 317 ? -15.353 -23.952 0.835   0.50 69.84  ? 580  VAL A C   1 
ATOM   2227 O  O   . VAL A 1 317 ? -15.124 -22.969 1.566   0.50 64.40  ? 580  VAL A O   1 
ATOM   2228 C  CB  . VAL A 1 317 ? -13.883 -23.607 -1.207  0.50 65.64  ? 580  VAL A CB  1 
ATOM   2229 C  CG1 . VAL A 1 317 ? -13.073 -24.870 -0.977  0.50 65.22  ? 580  VAL A CG1 1 
ATOM   2230 C  CG2 . VAL A 1 317 ? -13.856 -23.217 -2.675  0.50 65.08  ? 580  VAL A CG2 1 
ATOM   2231 N  N   . GLN A 1 318 ? -15.629 -25.182 1.282   0.50 75.69  ? 581  GLN A N   1 
ATOM   2232 C  CA  . GLN A 1 318 ? -15.661 -25.568 2.719   0.50 78.22  ? 581  GLN A CA  1 
ATOM   2233 C  C   . GLN A 1 318 ? -14.235 -25.850 3.201   0.50 81.95  ? 581  GLN A C   1 
ATOM   2234 O  O   . GLN A 1 318 ? -13.560 -26.700 2.584   0.50 76.57  ? 581  GLN A O   1 
ATOM   2235 C  CB  . GLN A 1 318 ? -16.543 -26.797 2.942   0.50 76.59  ? 581  GLN A CB  1 
ATOM   2236 C  CG  . GLN A 1 318 ? -18.021 -26.466 3.071   0.50 76.74  ? 581  GLN A CG  1 
ATOM   2237 C  CD  . GLN A 1 318 ? -18.645 -27.133 4.272   0.50 77.06  ? 581  GLN A CD  1 
ATOM   2238 O  OE1 . GLN A 1 318 ? -18.100 -28.081 4.835   0.50 78.10  ? 581  GLN A OE1 1 
ATOM   2239 N  NE2 . GLN A 1 318 ? -19.795 -26.625 4.687   0.50 76.12  ? 581  GLN A NE2 1 
ATOM   2240 N  N   . ARG A 1 319 ? -13.816 -25.158 4.266   0.50 91.97  ? 582  ARG A N   1 
ATOM   2241 C  CA  . ARG A 1 319 ? -12.506 -25.331 4.952   0.50 97.21  ? 582  ARG A CA  1 
ATOM   2242 C  C   . ARG A 1 319 ? -12.759 -25.889 6.353   0.50 105.72 ? 582  ARG A C   1 
ATOM   2243 O  O   . ARG A 1 319 ? -13.652 -25.406 7.047   0.50 104.58 ? 582  ARG A O   1 
ATOM   2244 C  CB  . ARG A 1 319 ? -11.768 -23.988 4.995   0.50 93.32  ? 582  ARG A CB  1 
ATOM   2245 C  CG  . ARG A 1 319 ? -10.303 -24.083 5.394   0.50 90.10  ? 582  ARG A CG  1 
ATOM   2246 C  CD  . ARG A 1 319 ? -9.489  -22.934 4.830   0.50 87.98  ? 582  ARG A CD  1 
ATOM   2247 N  NE  . ARG A 1 319 ? -10.192 -21.663 4.933   0.50 86.07  ? 582  ARG A NE  1 
ATOM   2248 C  CZ  . ARG A 1 319 ? -9.854  -20.680 5.759   0.50 85.05  ? 582  ARG A CZ  1 
ATOM   2249 N  NH1 . ARG A 1 319 ? -8.811  -20.817 6.559   0.50 87.21  ? 582  ARG A NH1 1 
ATOM   2250 N  NH2 . ARG A 1 319 ? -10.559 -19.562 5.780   0.50 80.38  ? 582  ARG A NH2 1 
ATOM   2251 N  N   . PRO A 1 320 ? -12.014 -26.927 6.813   1.00 117.27 ? 583  PRO A N   1 
ATOM   2252 C  CA  . PRO A 1 320 ? -12.223 -27.487 8.163   1.00 120.30 ? 583  PRO A CA  1 
ATOM   2253 C  C   . PRO A 1 320 ? -11.917 -26.600 9.394   1.00 123.91 ? 583  PRO A C   1 
ATOM   2254 O  O   . PRO A 1 320 ? -12.538 -26.795 10.439  1.00 129.56 ? 583  PRO A O   1 
ATOM   2255 C  CB  . PRO A 1 320 ? -11.264 -28.699 8.219   1.00 119.20 ? 583  PRO A CB  1 
ATOM   2256 C  CG  . PRO A 1 320 ? -10.825 -28.960 6.786   1.00 113.93 ? 583  PRO A CG  1 
ATOM   2257 C  CD  . PRO A 1 320 ? -10.951 -27.632 6.066   1.00 116.88 ? 583  PRO A CD  1 
ATOM   2258 N  N   . THR A 1 321 ? -10.974 -25.662 9.262   1.00 115.82 ? 584  THR A N   1 
ATOM   2259 C  CA  . THR A 1 321 ? -10.493 -24.751 10.339  1.00 109.28 ? 584  THR A CA  1 
ATOM   2260 C  C   . THR A 1 321 ? -11.690 -24.066 11.017  1.00 92.68  ? 584  THR A C   1 
ATOM   2261 O  O   . THR A 1 321 ? -11.595 -23.821 12.233  1.00 82.70  ? 584  THR A O   1 
ATOM   2262 C  CB  . THR A 1 321 ? -9.511  -23.730 9.751   1.00 120.06 ? 584  THR A CB  1 
ATOM   2263 O  OG1 . THR A 1 321 ? -10.207 -23.017 8.730   1.00 120.95 ? 584  THR A OG1 1 
ATOM   2264 C  CG2 . THR A 1 321 ? -8.268  -24.350 9.148   1.00 120.89 ? 584  THR A CG2 1 
ATOM   2265 N  N   . THR A 1 325 ? -16.085 -25.773 10.766  0.50 122.10 ? 588  THR A N   1 
ATOM   2266 C  CA  . THR A 1 325 ? -15.963 -25.614 9.292   0.50 122.70 ? 588  THR A CA  1 
ATOM   2267 C  C   . THR A 1 325 ? -16.569 -24.268 8.878   0.50 120.34 ? 588  THR A C   1 
ATOM   2268 O  O   . THR A 1 325 ? -17.722 -23.998 9.269   0.50 119.63 ? 588  THR A O   1 
ATOM   2269 C  CB  . THR A 1 325 ? -16.632 -26.780 8.552   0.50 126.62 ? 588  THR A CB  1 
ATOM   2270 O  OG1 . THR A 1 325 ? -16.216 -28.002 9.163   0.50 127.17 ? 588  THR A OG1 1 
ATOM   2271 C  CG2 . THR A 1 325 ? -16.298 -26.814 7.076   0.50 129.10 ? 588  THR A CG2 1 
ATOM   2272 N  N   . VAL A 1 326 ? -15.817 -23.462 8.121   0.50 118.22 ? 589  VAL A N   1 
ATOM   2273 C  CA  . VAL A 1 326 ? -16.258 -22.135 7.593   0.50 114.03 ? 589  VAL A CA  1 
ATOM   2274 C  C   . VAL A 1 326 ? -16.499 -22.258 6.084   0.50 108.13 ? 589  VAL A C   1 
ATOM   2275 O  O   . VAL A 1 326 ? -16.129 -23.302 5.506   0.50 109.72 ? 589  VAL A O   1 
ATOM   2276 C  CB  . VAL A 1 326 ? -15.226 -21.033 7.900   0.50 114.52 ? 589  VAL A CB  1 
ATOM   2277 C  CG1 . VAL A 1 326 ? -14.731 -21.111 9.336   0.50 117.22 ? 589  VAL A CG1 1 
ATOM   2278 C  CG2 . VAL A 1 326 ? -14.057 -21.067 6.927   0.50 116.35 ? 589  VAL A CG2 1 
ATOM   2279 N  N   . MET A 1 327 ? -17.104 -21.229 5.480   0.50 98.62  ? 590  MET A N   1 
ATOM   2280 C  CA  . MET A 1 327 ? -17.306 -21.114 4.010   0.50 90.25  ? 590  MET A CA  1 
ATOM   2281 C  C   . MET A 1 327 ? -16.419 -19.985 3.479   0.50 82.01  ? 590  MET A C   1 
ATOM   2282 O  O   . MET A 1 327 ? -16.560 -18.845 3.960   0.50 78.87  ? 590  MET A O   1 
ATOM   2283 C  CB  . MET A 1 327 ? -18.768 -20.816 3.661   0.50 89.37  ? 590  MET A CB  1 
ATOM   2284 C  CG  . MET A 1 327 ? -19.062 -20.925 2.175   0.50 87.34  ? 590  MET A CG  1 
ATOM   2285 S  SD  . MET A 1 327 ? -18.777 -22.595 1.524   0.50 84.84  ? 590  MET A SD  1 
ATOM   2286 C  CE  . MET A 1 327 ? -20.190 -23.469 2.196   0.50 84.81  ? 590  MET A CE  1 
ATOM   2287 N  N   . ASP A 1 328 ? -15.545 -20.307 2.523   0.50 76.49  ? 591  ASP A N   1 
ATOM   2288 C  CA  . ASP A 1 328 ? -14.545 -19.375 1.938   0.50 73.85  ? 591  ASP A CA  1 
ATOM   2289 C  C   . ASP A 1 328 ? -15.060 -18.902 0.570   0.50 71.85  ? 591  ASP A C   1 
ATOM   2290 O  O   . ASP A 1 328 ? -15.258 -19.758 -0.314  0.50 68.97  ? 591  ASP A O   1 
ATOM   2291 C  CB  . ASP A 1 328 ? -13.171 -20.052 1.874   0.50 71.88  ? 591  ASP A CB  1 
ATOM   2292 C  CG  . ASP A 1 328 ? -12.817 -20.873 3.112   0.50 67.87  ? 591  ASP A CG  1 
ATOM   2293 O  OD1 . ASP A 1 328 ? -13.406 -20.623 4.189   0.50 61.10  ? 591  ASP A OD1 1 
ATOM   2294 O  OD2 . ASP A 1 328 ? -11.956 -21.767 2.991   0.50 63.68  ? 591  ASP A OD2 1 
ATOM   2295 N  N   . ILE A 1 329 ? -15.290 -17.592 0.420   0.50 68.66  ? 592  ILE A N   1 
ATOM   2296 C  CA  . ILE A 1 329 ? -15.846 -16.958 -0.813  0.50 66.54  ? 592  ILE A CA  1 
ATOM   2297 C  C   . ILE A 1 329 ? -14.694 -16.339 -1.603  0.50 67.83  ? 592  ILE A C   1 
ATOM   2298 O  O   . ILE A 1 329 ? -14.210 -15.260 -1.203  0.50 69.72  ? 592  ILE A O   1 
ATOM   2299 C  CB  . ILE A 1 329 ? -16.920 -15.906 -0.476  0.50 67.46  ? 592  ILE A CB  1 
ATOM   2300 C  CG1 . ILE A 1 329 ? -18.162 -16.545 0.151   0.50 68.24  ? 592  ILE A CG1 1 
ATOM   2301 C  CG2 . ILE A 1 329 ? -17.265 -15.081 -1.707  0.50 66.63  ? 592  ILE A CG2 1 
ATOM   2302 C  CD1 . ILE A 1 329 ? -18.721 -17.709 -0.632  0.50 68.69  ? 592  ILE A CD1 1 
ATOM   2303 N  N   . ILE A 1 330 ? -14.295 -17.003 -2.691  1.00 69.30  ? 593  ILE A N   1 
ATOM   2304 C  CA  . ILE A 1 330 ? -13.083 -16.661 -3.476  1.00 68.15  ? 593  ILE A CA  1 
ATOM   2305 C  C   . ILE A 1 330 ? -13.502 -16.432 -4.924  1.00 64.14  ? 593  ILE A C   1 
ATOM   2306 O  O   . ILE A 1 330 ? -14.585 -16.869 -5.294  1.00 63.71  ? 593  ILE A O   1 
ATOM   2307 C  CB  . ILE A 1 330 ? -12.082 -17.817 -3.309  1.00 73.42  ? 593  ILE A CB  1 
ATOM   2308 C  CG1 . ILE A 1 330 ? -12.721 -19.180 -3.625  1.00 68.01  ? 593  ILE A CG1 1 
ATOM   2309 C  CG2 . ILE A 1 330 ? -11.491 -17.778 -1.906  1.00 70.68  ? 593  ILE A CG2 1 
ATOM   2310 C  CD1 . ILE A 1 330 ? -11.755 -20.348 -3.661  1.00 65.13  ? 593  ILE A CD1 1 
ATOM   2311 N  N   . SER A 1 331 ? -12.629 -15.810 -5.704  1.00 62.83  ? 594  SER A N   1 
ATOM   2312 C  CA  . SER A 1 331 ? -12.893 -15.445 -7.108  1.00 57.86  ? 594  SER A CA  1 
ATOM   2313 C  C   . SER A 1 331 ? -11.600 -15.534 -7.928  1.00 59.79  ? 594  SER A C   1 
ATOM   2314 O  O   . SER A 1 331 ? -10.509 -15.304 -7.370  1.00 56.58  ? 594  SER A O   1 
ATOM   2315 C  CB  . SER A 1 331 ? -13.468 -14.061 -7.132  1.00 55.89  ? 594  SER A CB  1 
ATOM   2316 O  OG  . SER A 1 331 ? -12.432 -13.096 -7.101  1.00 57.34  ? 594  SER A OG  1 
ATOM   2317 N  N   . ARG A 1 332 ? -11.732 -15.925 -9.196  0.50 57.19  ? 595  ARG A N   1 
ATOM   2318 C  CA  . ARG A 1 332 ? -10.624 -15.966 -10.179 0.50 56.13  ? 595  ARG A CA  1 
ATOM   2319 C  C   . ARG A 1 332 ? -11.244 -15.892 -11.567 0.50 54.90  ? 595  ARG A C   1 
ATOM   2320 O  O   . ARG A 1 332 ? -12.403 -16.321 -11.711 0.50 56.21  ? 595  ARG A O   1 
ATOM   2321 C  CB  . ARG A 1 332 ? -9.790  -17.239 -10.021 0.50 58.75  ? 595  ARG A CB  1 
ATOM   2322 C  CG  . ARG A 1 332 ? -10.364 -18.443 -10.748 0.50 60.17  ? 595  ARG A CG  1 
ATOM   2323 C  CD  . ARG A 1 332 ? -9.349  -19.565 -10.823 0.50 63.14  ? 595  ARG A CD  1 
ATOM   2324 N  NE  . ARG A 1 332 ? -8.042  -19.098 -11.268 0.50 62.54  ? 595  ARG A NE  1 
ATOM   2325 C  CZ  . ARG A 1 332 ? -6.954  -19.057 -10.506 0.50 63.09  ? 595  ARG A CZ  1 
ATOM   2326 N  NH1 . ARG A 1 332 ? -7.008  -19.452 -9.246  0.50 62.33  ? 595  ARG A NH1 1 
ATOM   2327 N  NH2 . ARG A 1 332 ? -5.811  -18.629 -11.013 0.50 63.92  ? 595  ARG A NH2 1 
ATOM   2328 N  N   . ARG A 1 333 ? -10.497 -15.359 -12.529 0.50 52.27  ? 596  ARG A N   1 
ATOM   2329 C  CA  . ARG A 1 333 ? -10.993 -15.045 -13.890 0.50 54.82  ? 596  ARG A CA  1 
ATOM   2330 C  C   . ARG A 1 333 ? -10.669 -16.207 -14.836 0.50 49.31  ? 596  ARG A C   1 
ATOM   2331 O  O   . ARG A 1 333 ? -11.421 -16.396 -15.806 0.50 46.65  ? 596  ARG A O   1 
ATOM   2332 C  CB  . ARG A 1 333 ? -10.358 -13.735 -14.363 0.50 57.75  ? 596  ARG A CB  1 
ATOM   2333 C  CG  . ARG A 1 333 ? -10.790 -12.513 -13.563 0.50 61.99  ? 596  ARG A CG  1 
ATOM   2334 C  CD  . ARG A 1 333 ? -10.692 -11.257 -14.410 0.50 66.14  ? 596  ARG A CD  1 
ATOM   2335 N  NE  . ARG A 1 333 ? -11.412 -11.416 -15.670 0.50 68.26  ? 596  ARG A NE  1 
ATOM   2336 C  CZ  . ARG A 1 333 ? -11.157 -10.728 -16.779 0.50 71.66  ? 596  ARG A CZ  1 
ATOM   2337 N  NH1 . ARG A 1 333 ? -10.189 -9.827  -16.790 0.50 73.80  ? 596  ARG A NH1 1 
ATOM   2338 N  NH2 . ARG A 1 333 ? -11.863 -10.951 -17.874 0.50 71.23  ? 596  ARG A NH2 1 
ATOM   2339 N  N   . ASP A 1 334 ? -9.582  -16.935 -14.558 0.50 46.43  ? 597  ASP A N   1 
ATOM   2340 C  CA  . ASP A 1 334 ? -8.998  -17.968 -15.457 0.50 45.87  ? 597  ASP A CA  1 
ATOM   2341 C  C   . ASP A 1 334 ? -9.416  -19.363 -14.977 0.50 42.86  ? 597  ASP A C   1 
ATOM   2342 O  O   . ASP A 1 334 ? -10.189 -19.446 -13.998 0.50 39.95  ? 597  ASP A O   1 
ATOM   2343 C  CB  . ASP A 1 334 ? -7.475  -17.822 -15.551 0.50 47.65  ? 597  ASP A CB  1 
ATOM   2344 C  CG  . ASP A 1 334 ? -6.708  -18.345 -14.346 0.50 48.37  ? 597  ASP A CG  1 
ATOM   2345 O  OD1 . ASP A 1 334 ? -7.350  -18.615 -13.313 0.50 49.20  ? 597  ASP A OD1 1 
ATOM   2346 O  OD2 . ASP A 1 334 ? -5.467  -18.479 -14.454 0.50 53.44  ? 597  ASP A OD2 1 
ATOM   2347 N  N   . GLN A 1 335 ? -8.933  -20.409 -15.664 1.00 43.39  ? 598  GLN A N   1 
ATOM   2348 C  CA  . GLN A 1 335 ? -9.239  -21.836 -15.364 1.00 39.20  ? 598  GLN A CA  1 
ATOM   2349 C  C   . GLN A 1 335 ? -10.634 -22.187 -15.881 1.00 39.97  ? 598  GLN A C   1 
ATOM   2350 O  O   . GLN A 1 335 ? -11.489 -21.279 -16.051 1.00 41.12  ? 598  GLN A O   1 
ATOM   2351 C  CB  . GLN A 1 335 ? -9.161  -22.223 -13.889 1.00 38.39  ? 598  GLN A CB  1 
ATOM   2352 C  CG  . GLN A 1 335 ? -7.840  -21.828 -13.247 1.00 44.90  ? 598  GLN A CG  1 
ATOM   2353 C  CD  . GLN A 1 335 ? -7.549  -22.625 -11.998 1.00 48.44  ? 598  GLN A CD  1 
ATOM   2354 O  OE1 . GLN A 1 335 ? -8.421  -23.291 -11.448 1.00 53.82  ? 598  GLN A OE1 1 
ATOM   2355 N  NE2 . GLN A 1 335 ? -6.292  -22.614 -11.596 1.00 44.53  ? 598  GLN A NE2 1 
ATOM   2356 N  N   . ARG A 1 336 ? -10.863 -23.482 -16.054 1.00 43.04  ? 599  ARG A N   1 
ATOM   2357 C  CA  . ARG A 1 336 ? -12.176 -24.034 -16.446 1.00 46.57  ? 599  ARG A CA  1 
ATOM   2358 C  C   . ARG A 1 336 ? -12.990 -24.313 -15.188 1.00 50.00  ? 599  ARG A C   1 
ATOM   2359 O  O   . ARG A 1 336 ? -12.487 -24.913 -14.241 1.00 50.54  ? 599  ARG A O   1 
ATOM   2360 C  CB  . ARG A 1 336 ? -12.032 -25.304 -17.286 1.00 43.94  ? 599  ARG A CB  1 
ATOM   2361 C  CG  . ARG A 1 336 ? -13.348 -25.983 -17.641 1.00 39.09  ? 599  ARG A CG  1 
ATOM   2362 C  CD  . ARG A 1 336 ? -13.967 -25.250 -18.817 1.00 38.12  ? 599  ARG A CD  1 
ATOM   2363 N  NE  . ARG A 1 336 ? -13.153 -25.495 -19.978 1.00 33.71  ? 599  ARG A NE  1 
ATOM   2364 C  CZ  . ARG A 1 336 ? -12.890 -24.624 -20.926 1.00 36.68  ? 599  ARG A CZ  1 
ATOM   2365 N  NH1 . ARG A 1 336 ? -13.388 -23.395 -20.881 1.00 34.33  ? 599  ARG A NH1 1 
ATOM   2366 N  NH2 . ARG A 1 336 ? -12.163 -25.017 -21.950 1.00 33.62  ? 599  ARG A NH2 1 
ATOM   2367 N  N   . GLY A 1 337 ? -14.202 -23.763 -15.206 0.50 53.84  ? 600  GLY A N   1 
ATOM   2368 C  CA  . GLY A 1 337 ? -15.267 -23.894 -14.201 0.50 57.00  ? 600  GLY A CA  1 
ATOM   2369 C  C   . GLY A 1 337 ? -16.587 -23.608 -14.885 0.50 58.01  ? 600  GLY A C   1 
ATOM   2370 O  O   . GLY A 1 337 ? -16.812 -22.443 -15.283 0.50 62.13  ? 600  GLY A O   1 
ATOM   2371 N  N   . SER A 1 338 ? -17.377 -24.659 -15.104 0.50 58.81  ? 601  SER A N   1 
ATOM   2372 C  CA  . SER A 1 338 ? -18.600 -24.657 -15.942 0.50 54.99  ? 601  SER A CA  1 
ATOM   2373 C  C   . SER A 1 338 ? -19.254 -26.036 -15.833 0.50 54.84  ? 601  SER A C   1 
ATOM   2374 O  O   . SER A 1 338 ? -18.585 -26.963 -15.342 0.50 52.01  ? 601  SER A O   1 
ATOM   2375 C  CB  . SER A 1 338 ? -18.258 -24.307 -17.369 0.50 55.85  ? 601  SER A CB  1 
ATOM   2376 O  OG  . SER A 1 338 ? -17.230 -23.326 -17.413 0.50 58.23  ? 601  SER A OG  1 
ATOM   2377 N  N   . GLY A 1 339 ? -20.511 -26.164 -16.256 0.50 55.61  ? 602  GLY A N   1 
ATOM   2378 C  CA  . GLY A 1 339 ? -21.185 -27.473 -16.348 0.50 56.36  ? 602  GLY A CA  1 
ATOM   2379 C  C   . GLY A 1 339 ? -20.301 -28.475 -17.073 0.50 53.34  ? 602  GLY A C   1 
ATOM   2380 O  O   . GLY A 1 339 ? -19.601 -28.061 -18.017 0.50 48.98  ? 602  GLY A O   1 
ATOM   2381 N  N   . GLN A 1 340 ? -20.326 -29.743 -16.652 0.50 52.84  ? 603  GLN A N   1 
ATOM   2382 C  CA  . GLN A 1 340 ? -19.444 -30.813 -17.189 0.50 54.02  ? 603  GLN A CA  1 
ATOM   2383 C  C   . GLN A 1 340 ? -19.673 -30.955 -18.700 0.50 50.71  ? 603  GLN A C   1 
ATOM   2384 O  O   . GLN A 1 340 ? -18.707 -31.280 -19.403 0.50 47.69  ? 603  GLN A O   1 
ATOM   2385 C  CB  . GLN A 1 340 ? -19.655 -32.134 -16.441 0.50 57.99  ? 603  GLN A CB  1 
ATOM   2386 C  CG  . GLN A 1 340 ? -21.062 -32.705 -16.560 0.50 62.76  ? 603  GLN A CG  1 
ATOM   2387 C  CD  . GLN A 1 340 ? -21.109 -34.202 -16.358 0.50 63.54  ? 603  GLN A CD  1 
ATOM   2388 O  OE1 . GLN A 1 340 ? -20.113 -34.906 -16.525 0.50 66.44  ? 603  GLN A OE1 1 
ATOM   2389 N  NE2 . GLN A 1 340 ? -22.284 -34.705 -16.009 0.50 63.54  ? 603  GLN A NE2 1 
ATOM   2390 N  N   . VAL A 1 341 ? -20.890 -30.702 -19.193 1.00 51.19  ? 604  VAL A N   1 
ATOM   2391 C  CA  . VAL A 1 341 ? -21.198 -30.888 -20.649 1.00 44.25  ? 604  VAL A CA  1 
ATOM   2392 C  C   . VAL A 1 341 ? -20.630 -29.718 -21.464 1.00 42.99  ? 604  VAL A C   1 
ATOM   2393 O  O   . VAL A 1 341 ? -19.995 -29.972 -22.541 1.00 35.08  ? 604  VAL A O   1 
ATOM   2394 C  CB  . VAL A 1 341 ? -22.691 -31.130 -20.924 1.00 49.00  ? 604  VAL A CB  1 
ATOM   2395 C  CG1 . VAL A 1 341 ? -22.932 -31.183 -22.429 1.00 55.58  ? 604  VAL A CG1 1 
ATOM   2396 C  CG2 . VAL A 1 341 ? -23.194 -32.411 -20.252 1.00 52.78  ? 604  VAL A CG2 1 
ATOM   2397 N  N   . VAL A 1 342 ? -20.861 -28.463 -21.052 1.00 38.28  ? 605  VAL A N   1 
ATOM   2398 C  CA  . VAL A 1 342 ? -20.158 -27.337 -21.738 1.00 38.61  ? 605  VAL A CA  1 
ATOM   2399 C  C   . VAL A 1 342 ? -18.639 -27.486 -21.571 1.00 34.81  ? 605  VAL A C   1 
ATOM   2400 O  O   . VAL A 1 342 ? -17.898 -27.232 -22.518 1.00 33.38  ? 605  VAL A O   1 
ATOM   2401 C  CB  . VAL A 1 342 ? -20.664 -25.973 -21.250 1.00 39.12  ? 605  VAL A CB  1 
ATOM   2402 C  CG1 . VAL A 1 342 ? -19.910 -24.833 -21.925 1.00 38.27  ? 605  VAL A CG1 1 
ATOM   2403 C  CG2 . VAL A 1 342 ? -22.155 -25.840 -21.524 1.00 40.92  ? 605  VAL A CG2 1 
ATOM   2404 N  N   . THR A 1 343 ? -18.159 -27.869 -20.402 1.00 32.03  ? 606  THR A N   1 
ATOM   2405 C  CA  . THR A 1 343 ? -16.698 -28.111 -20.206 1.00 34.94  ? 606  THR A CA  1 
ATOM   2406 C  C   . THR A 1 343 ? -16.159 -29.072 -21.282 1.00 31.15  ? 606  THR A C   1 
ATOM   2407 O  O   . THR A 1 343 ? -15.094 -28.804 -21.773 1.00 31.52  ? 606  THR A O   1 
ATOM   2408 C  CB  . THR A 1 343 ? -16.406 -28.622 -18.787 1.00 34.37  ? 606  THR A CB  1 
ATOM   2409 O  OG1 . THR A 1 343 ? -16.753 -27.532 -17.949 1.00 36.25  ? 606  THR A OG1 1 
ATOM   2410 C  CG2 . THR A 1 343 ? -14.967 -29.031 -18.547 1.00 36.27  ? 606  THR A CG2 1 
ATOM   2411 N  N   . TYR A 1 344 ? -16.883 -30.155 -21.596 1.00 29.58  ? 607  TYR A N   1 
ATOM   2412 C  CA  . TYR A 1 344 ? -16.440 -31.176 -22.556 1.00 30.59  ? 607  TYR A CA  1 
ATOM   2413 C  C   . TYR A 1 344 ? -16.262 -30.497 -23.912 1.00 30.88  ? 607  TYR A C   1 
ATOM   2414 O  O   . TYR A 1 344 ? -15.210 -30.728 -24.550 1.00 27.96  ? 607  TYR A O   1 
ATOM   2415 C  CB  . TYR A 1 344 ? -17.396 -32.371 -22.609 1.00 31.19  ? 607  TYR A CB  1 
ATOM   2416 C  CG  . TYR A 1 344 ? -17.011 -33.392 -23.649 1.00 31.26  ? 607  TYR A CG  1 
ATOM   2417 C  CD1 . TYR A 1 344 ? -16.031 -34.334 -23.372 1.00 31.72  ? 607  TYR A CD1 1 
ATOM   2418 C  CD2 . TYR A 1 344 ? -17.549 -33.362 -24.927 1.00 30.41  ? 607  TYR A CD2 1 
ATOM   2419 C  CE1 . TYR A 1 344 ? -15.636 -35.254 -24.326 1.00 31.91  ? 607  TYR A CE1 1 
ATOM   2420 C  CE2 . TYR A 1 344 ? -17.197 -34.306 -25.881 1.00 35.23  ? 607  TYR A CE2 1 
ATOM   2421 C  CZ  . TYR A 1 344 ? -16.242 -35.265 -25.573 1.00 34.06  ? 607  TYR A CZ  1 
ATOM   2422 O  OH  . TYR A 1 344 ? -15.824 -36.155 -26.527 1.00 37.35  ? 607  TYR A OH  1 
ATOM   2423 N  N   . GLY A 1 345 ? -17.252 -29.719 -24.370 1.00 26.97  ? 608  GLY A N   1 
ATOM   2424 C  CA  . GLY A 1 345 ? -17.197 -29.183 -25.748 1.00 27.84  ? 608  GLY A CA  1 
ATOM   2425 C  C   . GLY A 1 345 ? -16.120 -28.113 -25.876 1.00 24.88  ? 608  GLY A C   1 
ATOM   2426 O  O   . GLY A 1 345 ? -15.383 -28.123 -26.846 1.00 30.35  ? 608  GLY A O   1 
ATOM   2427 N  N   . LEU A 1 346 ? -15.975 -27.256 -24.891 1.00 26.06  ? 609  LEU A N   1 
ATOM   2428 C  CA  . LEU A 1 346 ? -14.965 -26.197 -24.990 1.00 29.16  ? 609  LEU A CA  1 
ATOM   2429 C  C   . LEU A 1 346 ? -13.550 -26.787 -24.783 1.00 25.61  ? 609  LEU A C   1 
ATOM   2430 O  O   . LEU A 1 346 ? -12.640 -26.255 -25.431 1.00 28.37  ? 609  LEU A O   1 
ATOM   2431 C  CB  . LEU A 1 346 ? -15.290 -25.097 -23.975 1.00 30.21  ? 609  LEU A CB  1 
ATOM   2432 C  CG  . LEU A 1 346 ? -16.614 -24.381 -24.181 1.00 30.90  ? 609  LEU A CG  1 
ATOM   2433 C  CD1 . LEU A 1 346 ? -16.789 -23.312 -23.114 1.00 36.79  ? 609  LEU A CD1 1 
ATOM   2434 C  CD2 . LEU A 1 346 ? -16.674 -23.765 -25.555 1.00 29.63  ? 609  LEU A CD2 1 
ATOM   2435 N  N   . ASN A 1 347 ? -13.367 -27.757 -23.874 1.00 27.28  ? 610  ASN A N   1 
ATOM   2436 C  CA  . ASN A 1 347 ? -12.105 -28.556 -23.796 1.00 25.33  ? 610  ASN A CA  1 
ATOM   2437 C  C   . ASN A 1 347 ? -11.797 -29.147 -25.174 1.00 23.71  ? 610  ASN A C   1 
ATOM   2438 O  O   . ASN A 1 347 ? -10.668 -28.966 -25.647 1.00 24.61  ? 610  ASN A O   1 
ATOM   2439 C  CB  . ASN A 1 347 ? -12.167 -29.625 -22.705 1.00 24.29  ? 610  ASN A CB  1 
ATOM   2440 C  CG  . ASN A 1 347 ? -11.977 -29.008 -21.345 1.00 27.24  ? 610  ASN A CG  1 
ATOM   2441 O  OD1 . ASN A 1 347 ? -11.638 -27.828 -21.203 1.00 27.75  ? 610  ASN A OD1 1 
ATOM   2442 N  ND2 . ASN A 1 347 ? -12.120 -29.813 -20.319 1.00 30.32  ? 610  ASN A ND2 1 
ATOM   2443 N  N   . THR A 1 348 ? -12.746 -29.806 -25.845 1.00 25.93  ? 611  THR A N   1 
ATOM   2444 C  CA  . THR A 1 348 ? -12.500 -30.352 -27.197 1.00 23.73  ? 611  THR A CA  1 
ATOM   2445 C  C   . THR A 1 348 ? -12.012 -29.246 -28.144 1.00 27.43  ? 611  THR A C   1 
ATOM   2446 O  O   . THR A 1 348 ? -11.029 -29.473 -28.911 1.00 24.66  ? 611  THR A O   1 
ATOM   2447 C  CB  . THR A 1 348 ? -13.707 -31.080 -27.760 1.00 23.51  ? 611  THR A CB  1 
ATOM   2448 O  OG1 . THR A 1 348 ? -14.105 -32.061 -26.805 1.00 25.56  ? 611  THR A OG1 1 
ATOM   2449 C  CG2 . THR A 1 348 ? -13.392 -31.716 -29.075 1.00 22.33  ? 611  THR A CG2 1 
ATOM   2450 N  N   . PHE A 1 349 ? -12.703 -28.108 -28.143 1.00 27.41  ? 612  PHE A N   1 
ATOM   2451 C  CA  . PHE A 1 349 ? -12.417 -26.990 -29.074 1.00 27.97  ? 612  PHE A CA  1 
ATOM   2452 C  C   . PHE A 1 349 ? -10.974 -26.519 -28.878 1.00 25.41  ? 612  PHE A C   1 
ATOM   2453 O  O   . PHE A 1 349 ? -10.237 -26.369 -29.854 1.00 26.99  ? 612  PHE A O   1 
ATOM   2454 C  CB  . PHE A 1 349 ? -13.398 -25.855 -28.783 1.00 27.83  ? 612  PHE A CB  1 
ATOM   2455 C  CG  . PHE A 1 349 ? -13.151 -24.712 -29.703 1.00 25.99  ? 612  PHE A CG  1 
ATOM   2456 C  CD1 . PHE A 1 349 ? -13.697 -24.710 -30.974 1.00 30.57  ? 612  PHE A CD1 1 
ATOM   2457 C  CD2 . PHE A 1 349 ? -12.343 -23.662 -29.293 1.00 25.26  ? 612  PHE A CD2 1 
ATOM   2458 C  CE1 . PHE A 1 349 ? -13.413 -23.662 -31.849 1.00 29.08  ? 612  PHE A CE1 1 
ATOM   2459 C  CE2 . PHE A 1 349 ? -12.084 -22.608 -30.156 1.00 28.43  ? 612  PHE A CE2 1 
ATOM   2460 C  CZ  . PHE A 1 349 ? -12.624 -22.607 -31.411 1.00 30.80  ? 612  PHE A CZ  1 
ATOM   2461 N  N   . THR A 1 350 ? -10.602 -26.266 -27.629 1.00 22.34  ? 613  THR A N   1 
ATOM   2462 C  CA  . THR A 1 350 ? -9.325  -25.606 -27.296 1.00 31.14  ? 613  THR A CA  1 
ATOM   2463 C  C   . THR A 1 350 ? -8.194  -26.633 -27.501 1.00 28.96  ? 613  THR A C   1 
ATOM   2464 O  O   . THR A 1 350 ? -7.113  -26.259 -27.964 1.00 29.76  ? 613  THR A O   1 
ATOM   2465 C  CB  . THR A 1 350 ? -9.389  -24.995 -25.898 1.00 32.01  ? 613  THR A CB  1 
ATOM   2466 O  OG1 . THR A 1 350 ? -10.339 -23.930 -25.940 1.00 30.72  ? 613  THR A OG1 1 
ATOM   2467 C  CG2 . THR A 1 350 ? -8.030  -24.466 -25.483 1.00 36.69  ? 613  THR A CG2 1 
ATOM   2468 N  N   . ASN A 1 351 ? -8.482  -27.917 -27.277 1.00 24.64  ? 614  ASN A N   1 
ATOM   2469 C  CA  . ASN A 1 351 ? -7.520  -29.026 -27.515 1.00 25.07  ? 614  ASN A CA  1 
ATOM   2470 C  C   . ASN A 1 351 ? -7.315  -29.165 -29.023 1.00 26.75  ? 614  ASN A C   1 
ATOM   2471 O  O   . ASN A 1 351 ? -6.160  -29.284 -29.481 1.00 25.26  ? 614  ASN A O   1 
ATOM   2472 C  CB  . ASN A 1 351 ? -7.963  -30.305 -26.794 1.00 24.34  ? 614  ASN A CB  1 
ATOM   2473 C  CG  . ASN A 1 351 ? -6.787  -31.234 -26.523 1.00 30.32  ? 614  ASN A CG  1 
ATOM   2474 O  OD1 . ASN A 1 351 ? -5.613  -30.888 -26.803 1.00 28.68  ? 614  ASN A OD1 1 
ATOM   2475 N  ND2 . ASN A 1 351 ? -7.090  -32.398 -25.963 1.00 30.13  ? 614  ASN A ND2 1 
ATOM   2476 N  N   . MET A 1 352 ? -8.389  -29.070 -29.808 1.00 23.43  ? 615  MET A N   1 
ATOM   2477 C  CA  . MET A 1 352 ? -8.230  -29.173 -31.271 1.00 25.88  ? 615  MET A CA  1 
ATOM   2478 C  C   . MET A 1 352 ? -7.332  -28.009 -31.729 1.00 27.68  ? 615  MET A C   1 
ATOM   2479 O  O   . MET A 1 352 ? -6.450  -28.217 -32.628 1.00 30.53  ? 615  MET A O   1 
ATOM   2480 C  CB  . MET A 1 352 ? -9.572  -29.095 -32.015 1.00 26.40  ? 615  MET A CB  1 
ATOM   2481 C  CG  . MET A 1 352 ? -10.432 -30.309 -31.840 1.00 27.92  ? 615  MET A CG  1 
ATOM   2482 S  SD  . MET A 1 352 ? -12.144 -30.014 -32.594 1.00 33.15  ? 615  MET A SD  1 
ATOM   2483 C  CE  . MET A 1 352 ? -11.798 -29.752 -34.305 1.00 28.51  ? 615  MET A CE  1 
ATOM   2484 N  N   . GLU A 1 353 ? -7.566  -26.843 -31.158 1.00 28.00  ? 616  GLU A N   1 
ATOM   2485 C  CA  . GLU A 1 353 ? -6.813  -25.605 -31.521 1.00 29.51  ? 616  GLU A CA  1 
ATOM   2486 C  C   . GLU A 1 353 ? -5.312  -25.813 -31.193 1.00 28.07  ? 616  GLU A C   1 
ATOM   2487 O  O   . GLU A 1 353 ? -4.466  -25.571 -32.024 1.00 28.54  ? 616  GLU A O   1 
ATOM   2488 C  CB  . GLU A 1 353 ? -7.418  -24.455 -30.727 1.00 31.30  ? 616  GLU A CB  1 
ATOM   2489 C  CG  . GLU A 1 353 ? -6.841  -23.091 -31.094 1.00 34.49  ? 616  GLU A CG  1 
ATOM   2490 C  CD  . GLU A 1 353 ? -7.084  -22.073 -29.985 1.00 36.37  ? 616  GLU A CD  1 
ATOM   2491 O  OE1 . GLU A 1 353 ? -8.273  -21.665 -29.830 1.00 41.66  ? 616  GLU A OE1 1 
ATOM   2492 O  OE2 . GLU A 1 353 ? -6.115  -21.822 -29.154 1.00 37.26  ? 616  GLU A OE2 1 
ATOM   2493 N  N   . ALA A 1 354 ? -5.013  -26.157 -29.959 1.00 27.98  ? 617  ALA A N   1 
ATOM   2494 C  CA  . ALA A 1 354 ? -3.651  -26.397 -29.458 1.00 28.99  ? 617  ALA A CA  1 
ATOM   2495 C  C   . ALA A 1 354 ? -2.937  -27.423 -30.335 1.00 30.59  ? 617  ALA A C   1 
ATOM   2496 O  O   . ALA A 1 354 ? -1.765  -27.229 -30.645 1.00 29.92  ? 617  ALA A O   1 
ATOM   2497 C  CB  . ALA A 1 354 ? -3.763  -26.882 -28.075 1.00 27.65  ? 617  ALA A CB  1 
ATOM   2498 N  N   . GLN A 1 355 ? -3.598  -28.532 -30.667 1.00 26.32  ? 618  GLN A N   1 
ATOM   2499 C  CA  . GLN A 1 355 ? -2.937  -29.591 -31.455 1.00 26.48  ? 618  GLN A CA  1 
ATOM   2500 C  C   . GLN A 1 355 ? -2.720  -29.162 -32.903 1.00 28.21  ? 618  GLN A C   1 
ATOM   2501 O  O   . GLN A 1 355 ? -1.716  -29.624 -33.514 1.00 25.97  ? 618  GLN A O   1 
ATOM   2502 C  CB  . GLN A 1 355 ? -3.676  -30.929 -31.369 1.00 26.59  ? 618  GLN A CB  1 
ATOM   2503 C  CG  . GLN A 1 355 ? -3.901  -31.438 -29.964 1.00 26.26  ? 618  GLN A CG  1 
ATOM   2504 C  CD  . GLN A 1 355 ? -2.631  -31.611 -29.164 1.00 29.14  ? 618  GLN A CD  1 
ATOM   2505 O  OE1 . GLN A 1 355 ? -1.579  -31.998 -29.636 1.00 28.75  ? 618  GLN A OE1 1 
ATOM   2506 N  NE2 . GLN A 1 355 ? -2.747  -31.360 -27.887 1.00 26.82  ? 618  GLN A NE2 1 
ATOM   2507 N  N   . LEU A 1 356 ? -3.587  -28.366 -33.523 1.00 29.75  ? 619  LEU A N   1 
ATOM   2508 C  CA  . LEU A 1 356 ? -3.300  -27.886 -34.913 1.00 28.90  ? 619  LEU A CA  1 
ATOM   2509 C  C   . LEU A 1 356 ? -2.058  -26.955 -34.862 1.00 29.71  ? 619  LEU A C   1 
ATOM   2510 O  O   . LEU A 1 356 ? -1.277  -26.974 -35.802 1.00 33.25  ? 619  LEU A O   1 
ATOM   2511 C  CB  . LEU A 1 356 ? -4.464  -27.071 -35.482 1.00 28.86  ? 619  LEU A CB  1 
ATOM   2512 C  CG  . LEU A 1 356 ? -5.589  -27.812 -36.182 1.00 31.34  ? 619  LEU A CG  1 
ATOM   2513 C  CD1 . LEU A 1 356 ? -6.690  -26.834 -36.540 1.00 33.06  ? 619  LEU A CD1 1 
ATOM   2514 C  CD2 . LEU A 1 356 ? -5.145  -28.542 -37.449 1.00 32.82  ? 619  LEU A CD2 1 
ATOM   2515 N  N   . ILE A 1 357 ? -1.925  -26.151 -33.828 1.00 28.84  ? 620  ILE A N   1 
ATOM   2516 C  CA  . ILE A 1 357 ? -0.755  -25.229 -33.640 1.00 30.87  ? 620  ILE A CA  1 
ATOM   2517 C  C   . ILE A 1 357 ? 0.504   -26.085 -33.403 1.00 35.56  ? 620  ILE A C   1 
ATOM   2518 O  O   . ILE A 1 357 ? 1.466   -25.877 -34.132 1.00 30.37  ? 620  ILE A O   1 
ATOM   2519 C  CB  . ILE A 1 357 ? -1.031  -24.221 -32.531 1.00 30.19  ? 620  ILE A CB  1 
ATOM   2520 C  CG1 . ILE A 1 357 ? -2.207  -23.328 -32.922 1.00 30.08  ? 620  ILE A CG1 1 
ATOM   2521 C  CG2 . ILE A 1 357 ? 0.199   -23.381 -32.198 1.00 34.75  ? 620  ILE A CG2 1 
ATOM   2522 C  CD1 . ILE A 1 357 ? -2.752  -22.519 -31.807 1.00 31.50  ? 620  ILE A CD1 1 
ATOM   2523 N  N   . ARG A 1 358 ? 0.432   -27.168 -32.610 1.00 29.44  ? 621  ARG A N   1 
ATOM   2524 C  CA  . ARG A 1 358 ? 1.608   -28.035 -32.436 1.00 27.05  ? 621  ARG A CA  1 
ATOM   2525 C  C   . ARG A 1 358 ? 1.948   -28.668 -33.774 1.00 31.32  ? 621  ARG A C   1 
ATOM   2526 O  O   . ARG A 1 358 ? 3.176   -28.721 -34.091 1.00 33.18  ? 621  ARG A O   1 
ATOM   2527 C  CB  . ARG A 1 358 ? 1.446   -29.043 -31.305 1.00 32.84  ? 621  ARG A CB  1 
ATOM   2528 C  CG  . ARG A 1 358 ? 2.708   -29.870 -31.128 1.00 29.23  ? 621  ARG A CG  1 
ATOM   2529 C  CD  . ARG A 1 358 ? 2.613   -30.740 -29.903 1.00 29.60  ? 621  ARG A CD  1 
ATOM   2530 N  NE  . ARG A 1 358 ? 3.739   -31.648 -29.854 1.00 28.32  ? 621  ARG A NE  1 
ATOM   2531 C  CZ  . ARG A 1 358 ? 3.930   -32.631 -28.966 1.00 30.50  ? 621  ARG A CZ  1 
ATOM   2532 N  NH1 . ARG A 1 358 ? 2.992   -32.995 -28.106 1.00 27.47  ? 621  ARG A NH1 1 
ATOM   2533 N  NH2 . ARG A 1 358 ? 5.063   -33.321 -29.015 1.00 34.17  ? 621  ARG A NH2 1 
ATOM   2534 N  N   . GLN A 1 359 ? 0.952   -29.088 -34.564 1.00 27.52  ? 622  GLN A N   1 
ATOM   2535 C  CA  . GLN A 1 359 ? 1.204   -29.570 -35.932 1.00 27.05  ? 622  GLN A CA  1 
ATOM   2536 C  C   . GLN A 1 359 ? 1.864   -28.432 -36.762 1.00 33.22  ? 622  GLN A C   1 
ATOM   2537 O  O   . GLN A 1 359 ? 2.837   -28.709 -37.469 1.00 36.27  ? 622  GLN A O   1 
ATOM   2538 C  CB  . GLN A 1 359 ? -0.038  -30.131 -36.614 1.00 29.68  ? 622  GLN A CB  1 
ATOM   2539 C  CG  . GLN A 1 359 ? -0.518  -31.470 -36.060 1.00 28.12  ? 622  GLN A CG  1 
ATOM   2540 C  CD  . GLN A 1 359 ? -1.538  -32.086 -36.961 1.00 28.07  ? 622  GLN A CD  1 
ATOM   2541 O  OE1 . GLN A 1 359 ? -1.237  -32.529 -38.055 1.00 28.19  ? 622  GLN A OE1 1 
ATOM   2542 N  NE2 . GLN A 1 359 ? -2.774  -32.147 -36.481 1.00 30.22  ? 622  GLN A NE2 1 
ATOM   2543 N  N   . MET A 1 360 ? 1.372   -27.209 -36.732 1.00 30.92  ? 623  MET A N   1 
ATOM   2544 C  CA  . MET A 1 360 ? 1.985   -26.104 -37.524 1.00 36.22  ? 623  MET A CA  1 
ATOM   2545 C  C   . MET A 1 360 ? 3.468   -25.951 -37.104 1.00 34.28  ? 623  MET A C   1 
ATOM   2546 O  O   . MET A 1 360 ? 4.294   -25.771 -37.973 1.00 35.48  ? 623  MET A O   1 
ATOM   2547 C  CB  . MET A 1 360 ? 1.276   -24.773 -37.261 1.00 34.45  ? 623  MET A CB  1 
ATOM   2548 C  CG  . MET A 1 360 ? -0.030  -24.597 -37.977 1.00 42.38  ? 623  MET A CG  1 
ATOM   2549 S  SD  . MET A 1 360 ? -0.727  -23.091 -37.290 1.00 40.78  ? 623  MET A SD  1 
ATOM   2550 C  CE  . MET A 1 360 ? -2.486  -23.403 -37.422 1.00 44.34  ? 623  MET A CE  1 
ATOM   2551 N  N   . GLU A 1 361 ? 3.757   -25.949 -35.810 1.00 30.93  ? 624  GLU A N   1 
ATOM   2552 C  CA  . GLU A 1 361 ? 5.132   -25.850 -35.307 1.00 33.23  ? 624  GLU A CA  1 
ATOM   2553 C  C   . GLU A 1 361 ? 5.993   -26.956 -35.917 1.00 39.58  ? 624  GLU A C   1 
ATOM   2554 O  O   . GLU A 1 361 ? 7.109   -26.665 -36.337 1.00 34.89  ? 624  GLU A O   1 
ATOM   2555 C  CB  . GLU A 1 361 ? 5.169   -25.911 -33.785 1.00 36.69  ? 624  GLU A CB  1 
ATOM   2556 C  CG  . GLU A 1 361 ? 6.549   -25.578 -33.243 1.00 39.51  ? 624  GLU A CG  1 
ATOM   2557 C  CD  . GLU A 1 361 ? 6.641   -25.265 -31.765 1.00 38.63  ? 624  GLU A CD  1 
ATOM   2558 O  OE1 . GLU A 1 361 ? 7.780   -25.190 -31.247 1.00 42.67  ? 624  GLU A OE1 1 
ATOM   2559 O  OE2 . GLU A 1 361 ? 5.584   -25.018 -31.133 1.00 41.84  ? 624  GLU A OE2 1 
ATOM   2560 N  N   . GLY A 1 362 ? 5.534   -28.204 -35.956 1.00 31.46  ? 625  GLY A N   1 
ATOM   2561 C  CA  . GLY A 1 362 ? 6.375   -29.303 -36.436 1.00 34.30  ? 625  GLY A CA  1 
ATOM   2562 C  C   . GLY A 1 362 ? 6.654   -29.151 -37.936 1.00 40.91  ? 625  GLY A C   1 
ATOM   2563 O  O   . GLY A 1 362 ? 7.735   -29.578 -38.388 1.00 38.08  ? 625  GLY A O   1 
ATOM   2564 N  N   . GLU A 1 363 ? 5.701   -28.587 -38.684 1.00 32.31  ? 626  GLU A N   1 
ATOM   2565 C  CA  . GLU A 1 363 ? 5.782   -28.459 -40.152 1.00 33.28  ? 626  GLU A CA  1 
ATOM   2566 C  C   . GLU A 1 363 ? 6.551   -27.165 -40.516 1.00 33.47  ? 626  GLU A C   1 
ATOM   2567 O  O   . GLU A 1 363 ? 6.672   -26.890 -41.665 1.00 36.46  ? 626  GLU A O   1 
ATOM   2568 C  CB  . GLU A 1 363 ? 4.378   -28.471 -40.773 1.00 30.03  ? 626  GLU A CB  1 
ATOM   2569 C  CG  . GLU A 1 363 ? 3.750   -29.870 -40.720 1.00 34.20  ? 626  GLU A CG  1 
ATOM   2570 C  CD  . GLU A 1 363 ? 2.354   -29.994 -41.301 1.00 38.76  ? 626  GLU A CD  1 
ATOM   2571 O  OE1 . GLU A 1 363 ? 2.169   -29.443 -42.437 1.00 35.00  ? 626  GLU A OE1 1 
ATOM   2572 O  OE2 . GLU A 1 363 ? 1.448   -30.637 -40.620 1.00 32.45  ? 626  GLU A OE2 1 
ATOM   2573 N  N   . GLY A 1 364 ? 7.013   -26.391 -39.567 1.00 30.60  ? 627  GLY A N   1 
ATOM   2574 C  CA  . GLY A 1 364 ? 7.778   -25.161 -39.852 1.00 40.03  ? 627  GLY A CA  1 
ATOM   2575 C  C   . GLY A 1 364 ? 6.923   -24.027 -40.408 1.00 49.32  ? 627  GLY A C   1 
ATOM   2576 O  O   . GLY A 1 364 ? 7.513   -23.186 -41.118 1.00 48.52  ? 627  GLY A O   1 
ATOM   2577 N  N   . VAL A 1 365 ? 5.605   -23.966 -40.116 1.00 39.24  ? 628  VAL A N   1 
ATOM   2578 C  CA  . VAL A 1 365 ? 4.706   -22.921 -40.686 1.00 39.44  ? 628  VAL A CA  1 
ATOM   2579 C  C   . VAL A 1 365 ? 5.138   -21.557 -40.129 1.00 39.28  ? 628  VAL A C   1 
ATOM   2580 O  O   . VAL A 1 365 ? 4.997   -20.559 -40.841 1.00 42.76  ? 628  VAL A O   1 
ATOM   2581 C  CB  . VAL A 1 365 ? 3.219   -23.230 -40.426 1.00 42.05  ? 628  VAL A CB  1 
ATOM   2582 C  CG1 . VAL A 1 365 ? 2.319   -22.131 -40.970 1.00 43.32  ? 628  VAL A CG1 1 
ATOM   2583 C  CG2 . VAL A 1 365 ? 2.827   -24.555 -41.063 1.00 43.92  ? 628  VAL A CG2 1 
ATOM   2584 N  N   . PHE A 1 366 ? 5.567   -21.510 -38.873 1.00 43.28  ? 629  PHE A N   1 
ATOM   2585 C  CA  . PHE A 1 366 ? 6.058   -20.301 -38.159 1.00 45.83  ? 629  PHE A CA  1 
ATOM   2586 C  C   . PHE A 1 366 ? 7.403   -20.638 -37.500 1.00 54.19  ? 629  PHE A C   1 
ATOM   2587 O  O   . PHE A 1 366 ? 7.657   -21.814 -37.277 1.00 49.14  ? 629  PHE A O   1 
ATOM   2588 C  CB  . PHE A 1 366 ? 5.027   -19.791 -37.154 1.00 44.50  ? 629  PHE A CB  1 
ATOM   2589 C  CG  . PHE A 1 366 ? 4.826   -20.638 -35.936 1.00 44.98  ? 629  PHE A CG  1 
ATOM   2590 C  CD1 . PHE A 1 366 ? 3.878   -21.647 -35.945 1.00 45.67  ? 629  PHE A CD1 1 
ATOM   2591 C  CD2 . PHE A 1 366 ? 5.550   -20.412 -34.779 1.00 46.29  ? 629  PHE A CD2 1 
ATOM   2592 C  CE1 . PHE A 1 366 ? 3.705   -22.448 -34.835 1.00 40.68  ? 629  PHE A CE1 1 
ATOM   2593 C  CE2 . PHE A 1 366 ? 5.352   -21.201 -33.662 1.00 51.17  ? 629  PHE A CE2 1 
ATOM   2594 C  CZ  . PHE A 1 366 ? 4.439   -22.235 -33.703 1.00 40.58  ? 629  PHE A CZ  1 
ATOM   2595 N  N   . LYS A 1 367 ? 8.267   -19.647 -37.259 1.00 57.32  ? 630  LYS A N   1 
ATOM   2596 C  CA  . LYS A 1 367 ? 9.670   -19.891 -36.845 1.00 57.03  ? 630  LYS A CA  1 
ATOM   2597 C  C   . LYS A 1 367 ? 9.784   -19.700 -35.337 1.00 50.48  ? 630  LYS A C   1 
ATOM   2598 O  O   . LYS A 1 367 ? 10.600  -20.387 -34.727 1.00 52.20  ? 630  LYS A O   1 
ATOM   2599 C  CB  . LYS A 1 367 ? 10.605  -18.965 -37.631 1.00 75.99  ? 630  LYS A CB  1 
ATOM   2600 C  CG  . LYS A 1 367 ? 12.094  -19.146 -37.351 1.00 83.44  ? 630  LYS A CG  1 
ATOM   2601 C  CD  . LYS A 1 367 ? 12.982  -18.350 -38.296 1.00 88.11  ? 630  LYS A CD  1 
ATOM   2602 C  CE  . LYS A 1 367 ? 14.363  -18.083 -37.736 1.00 92.24  ? 630  LYS A CE  1 
ATOM   2603 N  NZ  . LYS A 1 367 ? 14.332  -17.076 -36.646 1.00 91.69  ? 630  LYS A NZ  1 
ATOM   2604 N  N   . SER A 1 368 ? 8.978   -18.835 -34.737 1.00 47.03  ? 631  SER A N   1 
ATOM   2605 C  CA  . SER A 1 368 ? 9.107   -18.484 -33.302 1.00 43.98  ? 631  SER A CA  1 
ATOM   2606 C  C   . SER A 1 368 ? 7.807   -17.930 -32.720 1.00 43.84  ? 631  SER A C   1 
ATOM   2607 O  O   . SER A 1 368 ? 7.123   -17.163 -33.408 1.00 45.98  ? 631  SER A O   1 
ATOM   2608 C  CB  . SER A 1 368 ? 10.176  -17.467 -33.096 1.00 54.98  ? 631  SER A CB  1 
ATOM   2609 O  OG  . SER A 1 368 ? 10.062  -16.892 -31.794 1.00 59.21  ? 631  SER A OG  1 
ATOM   2610 N  N   . ILE A 1 369 ? 7.580   -18.211 -31.436 1.00 47.85  ? 632  ILE A N   1 
ATOM   2611 C  CA  . ILE A 1 369 ? 6.334   -17.872 -30.692 1.00 54.88  ? 632  ILE A CA  1 
ATOM   2612 C  C   . ILE A 1 369 ? 6.430   -16.454 -30.144 1.00 59.32  ? 632  ILE A C   1 
ATOM   2613 O  O   . ILE A 1 369 ? 5.401   -15.911 -29.683 1.00 48.98  ? 632  ILE A O   1 
ATOM   2614 C  CB  . ILE A 1 369 ? 6.071   -18.843 -29.526 1.00 49.14  ? 632  ILE A CB  1 
ATOM   2615 C  CG1 . ILE A 1 369 ? 7.210   -18.847 -28.515 1.00 45.76  ? 632  ILE A CG1 1 
ATOM   2616 C  CG2 . ILE A 1 369 ? 5.771   -20.237 -30.038 1.00 51.90  ? 632  ILE A CG2 1 
ATOM   2617 C  CD1 . ILE A 1 369 ? 6.884   -19.572 -27.254 1.00 49.62  ? 632  ILE A CD1 1 
ATOM   2618 N  N   . GLN A 1 370 ? 7.627   -15.859 -30.196 0.50 62.31  ? 633  GLN A N   1 
ATOM   2619 C  CA  . GLN A 1 370 ? 7.898   -14.495 -29.671 0.50 63.34  ? 633  GLN A CA  1 
ATOM   2620 C  C   . GLN A 1 370 ? 7.029   -13.492 -30.438 0.50 59.12  ? 633  GLN A C   1 
ATOM   2621 O  O   . GLN A 1 370 ? 6.411   -12.628 -29.793 0.50 53.78  ? 633  GLN A O   1 
ATOM   2622 C  CB  . GLN A 1 370 ? 9.388   -14.166 -29.786 0.50 64.63  ? 633  GLN A CB  1 
ATOM   2623 C  CG  . GLN A 1 370 ? 9.973   -13.591 -28.502 0.50 69.70  ? 633  GLN A CG  1 
ATOM   2624 C  CD  . GLN A 1 370 ? 10.123  -14.627 -27.413 0.50 71.05  ? 633  GLN A CD  1 
ATOM   2625 O  OE1 . GLN A 1 370 ? 10.010  -15.827 -27.649 0.50 75.36  ? 633  GLN A OE1 1 
ATOM   2626 N  NE2 . GLN A 1 370 ? 10.389  -14.165 -26.201 0.50 74.13  ? 633  GLN A NE2 1 
ATOM   2627 N  N   . HIS A 1 371 ? 6.950   -13.640 -31.761 0.50 60.07  ? 634  HIS A N   1 
ATOM   2628 C  CA  . HIS A 1 371 ? 6.310   -12.657 -32.673 0.50 64.20  ? 634  HIS A CA  1 
ATOM   2629 C  C   . HIS A 1 371 ? 6.057   -13.302 -34.038 0.50 62.82  ? 634  HIS A C   1 
ATOM   2630 O  O   . HIS A 1 371 ? 6.969   -13.987 -34.557 0.50 57.80  ? 634  HIS A O   1 
ATOM   2631 C  CB  . HIS A 1 371 ? 7.187   -11.398 -32.769 0.50 69.90  ? 634  HIS A CB  1 
ATOM   2632 C  CG  . HIS A 1 371 ? 7.027   -10.642 -34.045 0.50 75.52  ? 634  HIS A CG  1 
ATOM   2633 N  ND1 . HIS A 1 371 ? 5.994   -9.744  -34.247 0.50 81.55  ? 634  HIS A ND1 1 
ATOM   2634 C  CD2 . HIS A 1 371 ? 7.760   -10.644 -35.182 0.50 77.99  ? 634  HIS A CD2 1 
ATOM   2635 C  CE1 . HIS A 1 371 ? 6.097   -9.225  -35.456 0.50 83.02  ? 634  HIS A CE1 1 
ATOM   2636 N  NE2 . HIS A 1 371 ? 7.173   -9.763  -36.051 0.50 81.06  ? 634  HIS A NE2 1 
ATOM   2637 N  N   . LEU A 1 372 ? 4.863   -13.072 -34.592 0.50 64.02  ? 635  LEU A N   1 
ATOM   2638 C  CA  . LEU A 1 372 ? 4.425   -13.599 -35.911 0.50 67.43  ? 635  LEU A CA  1 
ATOM   2639 C  C   . LEU A 1 372 ? 4.490   -12.473 -36.948 0.50 68.56  ? 635  LEU A C   1 
ATOM   2640 O  O   . LEU A 1 372 ? 3.607   -11.595 -36.928 0.50 72.59  ? 635  LEU A O   1 
ATOM   2641 C  CB  . LEU A 1 372 ? 3.002   -14.155 -35.788 0.50 67.15  ? 635  LEU A CB  1 
ATOM   2642 C  CG  . LEU A 1 372 ? 2.755   -15.467 -36.529 0.50 66.82  ? 635  LEU A CG  1 
ATOM   2643 C  CD1 . LEU A 1 372 ? 3.525   -16.601 -35.872 0.50 65.34  ? 635  LEU A CD1 1 
ATOM   2644 C  CD2 . LEU A 1 372 ? 1.271   -15.793 -36.589 0.50 66.49  ? 635  LEU A CD2 1 
ATOM   2645 N  N   . THR A 1 373 ? 5.506   -12.501 -37.812 0.50 68.15  ? 636  THR A N   1 
ATOM   2646 C  CA  . THR A 1 373 ? 5.664   -11.561 -38.949 0.50 66.83  ? 636  THR A CA  1 
ATOM   2647 C  C   . THR A 1 373 ? 4.343   -11.542 -39.725 0.50 68.94  ? 636  THR A C   1 
ATOM   2648 O  O   . THR A 1 373 ? 3.565   -12.508 -39.579 0.50 68.78  ? 636  THR A O   1 
ATOM   2649 C  CB  . THR A 1 373 ? 6.873   -11.955 -39.804 0.50 65.16  ? 636  THR A CB  1 
ATOM   2650 O  OG1 . THR A 1 373 ? 6.502   -13.067 -40.620 0.50 68.33  ? 636  THR A OG1 1 
ATOM   2651 C  CG2 . THR A 1 373 ? 8.080   -12.318 -38.968 0.50 65.44  ? 636  THR A CG2 1 
ATOM   2652 N  N   . VAL A 1 374 ? 4.095   -10.486 -40.503 0.50 66.70  ? 637  VAL A N   1 
ATOM   2653 C  CA  . VAL A 1 374 ? 2.813   -10.277 -41.239 0.50 68.03  ? 637  VAL A CA  1 
ATOM   2654 C  C   . VAL A 1 374 ? 2.670   -11.386 -42.289 0.50 69.73  ? 637  VAL A C   1 
ATOM   2655 O  O   . VAL A 1 374 ? 1.521   -11.778 -42.593 0.50 68.51  ? 637  VAL A O   1 
ATOM   2656 C  CB  . VAL A 1 374 ? 2.759   -8.879  -41.888 0.50 69.58  ? 637  VAL A CB  1 
ATOM   2657 C  CG1 . VAL A 1 374 ? 1.328   -8.373  -42.019 0.50 68.20  ? 637  VAL A CG1 1 
ATOM   2658 C  CG2 . VAL A 1 374 ? 3.618   -7.877  -41.132 0.50 69.39  ? 637  VAL A CG2 1 
ATOM   2659 N  N   . THR A 1 375 ? 3.799   -11.858 -42.825 0.50 65.76  ? 638  THR A N   1 
ATOM   2660 C  CA  . THR A 1 375 ? 3.866   -12.907 -43.878 0.50 65.86  ? 638  THR A CA  1 
ATOM   2661 C  C   . THR A 1 375 ? 3.666   -14.289 -43.239 0.50 62.83  ? 638  THR A C   1 
ATOM   2662 O  O   . THR A 1 375 ? 3.211   -15.201 -43.955 0.50 57.87  ? 638  THR A O   1 
ATOM   2663 C  CB  . THR A 1 375 ? 5.192   -12.828 -44.645 0.50 67.05  ? 638  THR A CB  1 
ATOM   2664 O  OG1 . THR A 1 375 ? 6.239   -13.156 -43.732 0.50 70.84  ? 638  THR A OG1 1 
ATOM   2665 C  CG2 . THR A 1 375 ? 5.448   -11.465 -45.251 0.50 68.16  ? 638  THR A CG2 1 
ATOM   2666 N  N   . GLU A 1 376 ? 4.023   -14.436 -41.956 1.00 61.35  ? 639  GLU A N   1 
ATOM   2667 C  CA  . GLU A 1 376 ? 3.788   -15.691 -41.179 1.00 65.66  ? 639  GLU A CA  1 
ATOM   2668 C  C   . GLU A 1 376 ? 2.278   -15.774 -40.933 1.00 61.78  ? 639  GLU A C   1 
ATOM   2669 O  O   . GLU A 1 376 ? 1.706   -16.807 -41.294 1.00 54.20  ? 639  GLU A O   1 
ATOM   2670 C  CB  . GLU A 1 376 ? 4.637   -15.770 -39.913 1.00 62.54  ? 639  GLU A CB  1 
ATOM   2671 C  CG  . GLU A 1 376 ? 6.037   -16.326 -40.174 1.00 56.02  ? 639  GLU A CG  1 
ATOM   2672 C  CD  . GLU A 1 376 ? 6.958   -16.246 -38.970 1.00 56.01  ? 639  GLU A CD  1 
ATOM   2673 O  OE1 . GLU A 1 376 ? 7.859   -17.094 -38.864 1.00 59.78  ? 639  GLU A OE1 1 
ATOM   2674 O  OE2 . GLU A 1 376 ? 6.758   -15.354 -38.120 1.00 60.61  ? 639  GLU A OE2 1 
ATOM   2675 N  N   . GLU A 1 377 ? 1.640   -14.667 -40.529 1.00 64.48  ? 640  GLU A N   1 
ATOM   2676 C  CA  . GLU A 1 377 ? 0.163   -14.599 -40.333 1.00 59.93  ? 640  GLU A CA  1 
ATOM   2677 C  C   . GLU A 1 377 ? -0.558  -15.130 -41.568 1.00 59.44  ? 640  GLU A C   1 
ATOM   2678 O  O   . GLU A 1 377 ? -1.470  -15.937 -41.439 1.00 61.17  ? 640  GLU A O   1 
ATOM   2679 C  CB  . GLU A 1 377 ? -0.330  -13.190 -40.039 1.00 59.50  ? 640  GLU A CB  1 
ATOM   2680 C  CG  . GLU A 1 377 ? -0.158  -12.799 -38.599 1.00 64.90  ? 640  GLU A CG  1 
ATOM   2681 C  CD  . GLU A 1 377 ? -0.757  -11.442 -38.275 1.00 73.90  ? 640  GLU A CD  1 
ATOM   2682 O  OE1 . GLU A 1 377 ? -1.933  -11.222 -38.641 1.00 82.50  ? 640  GLU A OE1 1 
ATOM   2683 O  OE2 . GLU A 1 377 ? -0.052  -10.619 -37.652 1.00 74.87  ? 640  GLU A OE2 1 
ATOM   2684 N  N   . ILE A 1 378 ? -0.141  -14.674 -42.749 0.50 60.97  ? 641  ILE A N   1 
ATOM   2685 C  CA  . ILE A 1 378 ? -0.746  -15.060 -44.059 0.50 58.39  ? 641  ILE A CA  1 
ATOM   2686 C  C   . ILE A 1 378 ? -0.450  -16.544 -44.330 0.50 57.71  ? 641  ILE A C   1 
ATOM   2687 O  O   . ILE A 1 378 ? -1.329  -17.230 -44.887 0.50 55.49  ? 641  ILE A O   1 
ATOM   2688 C  CB  . ILE A 1 378 ? -0.234  -14.125 -45.176 0.50 57.42  ? 641  ILE A CB  1 
ATOM   2689 C  CG1 . ILE A 1 378 ? -0.733  -14.541 -46.562 0.50 56.10  ? 641  ILE A CG1 1 
ATOM   2690 C  CG2 . ILE A 1 378 ? 1.283   -14.028 -45.137 0.50 58.82  ? 641  ILE A CG2 1 
ATOM   2691 C  CD1 . ILE A 1 378 ? 0.277   -15.330 -47.359 0.50 57.96  ? 641  ILE A CD1 1 
ATOM   2692 N  N   . ALA A 1 379 ? 0.739   -17.022 -43.949 1.00 55.53  ? 642  ALA A N   1 
ATOM   2693 C  CA  . ALA A 1 379 ? 1.160   -18.435 -44.138 1.00 55.84  ? 642  ALA A CA  1 
ATOM   2694 C  C   . ALA A 1 379 ? 0.312   -19.383 -43.253 1.00 43.26  ? 642  ALA A C   1 
ATOM   2695 O  O   . ALA A 1 379 ? -0.132  -20.395 -43.779 1.00 40.60  ? 642  ALA A O   1 
ATOM   2696 C  CB  . ALA A 1 379 ? 2.639   -18.561 -43.832 1.00 54.55  ? 642  ALA A CB  1 
ATOM   2697 N  N   . VAL A 1 380 ? 0.122   -19.018 -41.979 1.00 38.33  ? 643  VAL A N   1 
ATOM   2698 C  CA  . VAL A 1 380 ? -0.716  -19.725 -40.982 1.00 45.90  ? 643  VAL A CA  1 
ATOM   2699 C  C   . VAL A 1 380 ? -2.145  -19.760 -41.525 1.00 47.38  ? 643  VAL A C   1 
ATOM   2700 O  O   . VAL A 1 380 ? -2.710  -20.872 -41.592 1.00 39.38  ? 643  VAL A O   1 
ATOM   2701 C  CB  . VAL A 1 380 ? -0.615  -19.083 -39.583 1.00 44.23  ? 643  VAL A CB  1 
ATOM   2702 C  CG1 . VAL A 1 380 ? -1.690  -19.616 -38.659 1.00 45.24  ? 643  VAL A CG1 1 
ATOM   2703 C  CG2 . VAL A 1 380 ? 0.755   -19.311 -38.949 1.00 43.00  ? 643  VAL A CG2 1 
ATOM   2704 N  N   . LYS A 1 381 ? -2.687  -18.641 -41.994 1.00 41.92  ? 644  LYS A N   1 
ATOM   2705 C  CA  . LYS A 1 381 ? -4.098  -18.668 -42.449 1.00 46.91  ? 644  LYS A CA  1 
ATOM   2706 C  C   . LYS A 1 381 ? -4.194  -19.512 -43.723 1.00 45.15  ? 644  LYS A C   1 
ATOM   2707 O  O   . LYS A 1 381 ? -5.204  -20.200 -43.898 1.00 42.71  ? 644  LYS A O   1 
ATOM   2708 C  CB  . LYS A 1 381 ? -4.609  -17.240 -42.658 1.00 59.25  ? 644  LYS A CB  1 
ATOM   2709 C  CG  . LYS A 1 381 ? -6.053  -17.149 -43.132 1.00 71.37  ? 644  LYS A CG  1 
ATOM   2710 C  CD  . LYS A 1 381 ? -6.753  -15.855 -42.778 1.00 84.53  ? 644  LYS A CD  1 
ATOM   2711 C  CE  . LYS A 1 381 ? -8.223  -15.875 -43.148 1.00 90.52  ? 644  LYS A CE  1 
ATOM   2712 N  NZ  . LYS A 1 381 ? -8.936  -14.654 -42.700 1.00 85.76  ? 644  LYS A NZ  1 
ATOM   2713 N  N   . ASN A 1 382 ? -3.149  -19.493 -44.543 1.00 41.09  ? 645  ASN A N   1 
ATOM   2714 C  CA  . ASN A 1 382 ? -3.146  -20.218 -45.839 1.00 44.59  ? 645  ASN A CA  1 
ATOM   2715 C  C   . ASN A 1 382 ? -2.993  -21.729 -45.614 1.00 43.61  ? 645  ASN A C   1 
ATOM   2716 O  O   . ASN A 1 382 ? -3.562  -22.514 -46.395 1.00 38.75  ? 645  ASN A O   1 
ATOM   2717 C  CB  . ASN A 1 382 ? -2.014  -19.718 -46.746 1.00 55.25  ? 645  ASN A CB  1 
ATOM   2718 C  CG  . ASN A 1 382 ? -2.385  -19.846 -48.201 1.00 68.54  ? 645  ASN A CG  1 
ATOM   2719 O  OD1 . ASN A 1 382 ? -3.254  -19.097 -48.654 1.00 85.22  ? 645  ASN A OD1 1 
ATOM   2720 N  ND2 . ASN A 1 382 ? -1.771  -20.798 -48.904 1.00 61.28  ? 645  ASN A ND2 1 
ATOM   2721 N  N   . TRP A 1 383 ? -2.200  -22.125 -44.613 1.00 43.06  ? 646  TRP A N   1 
ATOM   2722 C  CA  . TRP A 1 383 ? -2.066  -23.556 -44.185 1.00 39.75  ? 646  TRP A CA  1 
ATOM   2723 C  C   . TRP A 1 383 ? -3.475  -24.097 -43.784 1.00 33.47  ? 646  TRP A C   1 
ATOM   2724 O  O   . TRP A 1 383 ? -3.981  -25.106 -44.382 1.00 35.72  ? 646  TRP A O   1 
ATOM   2725 C  CB  . TRP A 1 383 ? -1.010  -23.575 -43.065 1.00 32.90  ? 646  TRP A CB  1 
ATOM   2726 C  CG  . TRP A 1 383 ? -0.587  -24.931 -42.576 1.00 42.13  ? 646  TRP A CG  1 
ATOM   2727 C  CD1 . TRP A 1 383 ? 0.415   -25.732 -43.055 1.00 42.37  ? 646  TRP A CD1 1 
ATOM   2728 C  CD2 . TRP A 1 383 ? -1.167  -25.649 -41.473 1.00 38.58  ? 646  TRP A CD2 1 
ATOM   2729 N  NE1 . TRP A 1 383 ? 0.504   -26.895 -42.327 1.00 38.64  ? 646  TRP A NE1 1 
ATOM   2730 C  CE2 . TRP A 1 383 ? -0.450  -26.864 -41.345 1.00 38.88  ? 646  TRP A CE2 1 
ATOM   2731 C  CE3 . TRP A 1 383 ? -2.226  -25.387 -40.601 1.00 34.60  ? 646  TRP A CE3 1 
ATOM   2732 C  CZ2 . TRP A 1 383 ? -0.736  -27.778 -40.336 1.00 36.37  ? 646  TRP A CZ2 1 
ATOM   2733 C  CZ3 . TRP A 1 383 ? -2.519  -26.299 -39.612 1.00 36.10  ? 646  TRP A CZ3 1 
ATOM   2734 C  CH2 . TRP A 1 383 ? -1.786  -27.482 -39.487 1.00 35.90  ? 646  TRP A CH2 1 
ATOM   2735 N  N   . LEU A 1 384 ? -4.146  -23.355 -42.906 1.00 35.61  ? 647  LEU A N   1 
ATOM   2736 C  CA  . LEU A 1 384 ? -5.508  -23.671 -42.409 1.00 41.99  ? 647  LEU A CA  1 
ATOM   2737 C  C   . LEU A 1 384 ? -6.453  -23.909 -43.591 1.00 38.11  ? 647  LEU A C   1 
ATOM   2738 O  O   . LEU A 1 384 ? -7.041  -25.011 -43.686 1.00 37.86  ? 647  LEU A O   1 
ATOM   2739 C  CB  . LEU A 1 384 ? -5.958  -22.557 -41.456 1.00 37.81  ? 647  LEU A CB  1 
ATOM   2740 C  CG  . LEU A 1 384 ? -5.278  -22.587 -40.088 1.00 38.09  ? 647  LEU A CG  1 
ATOM   2741 C  CD1 . LEU A 1 384 ? -5.746  -21.443 -39.217 1.00 37.52  ? 647  LEU A CD1 1 
ATOM   2742 C  CD2 . LEU A 1 384 ? -5.494  -23.898 -39.337 1.00 39.20  ? 647  LEU A CD2 1 
ATOM   2743 N  N   . VAL A 1 385 ? -6.549  -22.957 -44.513 1.00 44.62  ? 648  VAL A N   1 
ATOM   2744 C  CA  . VAL A 1 385 ? -7.459  -23.045 -45.687 1.00 41.32  ? 648  VAL A CA  1 
ATOM   2745 C  C   . VAL A 1 385 ? -7.050  -24.224 -46.563 1.00 42.66  ? 648  VAL A C   1 
ATOM   2746 O  O   . VAL A 1 385 ? -7.923  -24.970 -47.021 1.00 45.75  ? 648  VAL A O   1 
ATOM   2747 C  CB  . VAL A 1 385 ? -7.465  -21.726 -46.495 1.00 53.41  ? 648  VAL A CB  1 
ATOM   2748 C  CG1 . VAL A 1 385 ? -8.195  -21.880 -47.819 1.00 54.02  ? 648  VAL A CG1 1 
ATOM   2749 C  CG2 . VAL A 1 385 ? -8.068  -20.575 -45.696 1.00 55.38  ? 648  VAL A CG2 1 
ATOM   2750 N  N   . ARG A 1 386 ? -5.745  -24.391 -46.797 0.50 41.85  ? 649  ARG A N   1 
ATOM   2751 C  CA  . ARG A 1 386 ? -5.209  -25.409 -47.738 0.50 44.11  ? 649  ARG A CA  1 
ATOM   2752 C  C   . ARG A 1 386 ? -5.293  -26.809 -47.110 0.50 43.35  ? 649  ARG A C   1 
ATOM   2753 O  O   . ARG A 1 386 ? -5.780  -27.729 -47.801 0.50 42.32  ? 649  ARG A O   1 
ATOM   2754 C  CB  . ARG A 1 386 ? -3.773  -25.060 -48.145 0.50 49.67  ? 649  ARG A CB  1 
ATOM   2755 C  CG  . ARG A 1 386 ? -3.147  -26.056 -49.115 0.50 55.22  ? 649  ARG A CG  1 
ATOM   2756 C  CD  . ARG A 1 386 ? -1.750  -25.678 -49.603 0.50 58.77  ? 649  ARG A CD  1 
ATOM   2757 N  NE  . ARG A 1 386 ? -0.697  -25.872 -48.608 0.50 60.39  ? 649  ARG A NE  1 
ATOM   2758 C  CZ  . ARG A 1 386 ? -0.241  -24.920 -47.796 0.50 60.11  ? 649  ARG A CZ  1 
ATOM   2759 N  NH1 . ARG A 1 386 ? -0.749  -23.700 -47.855 0.50 62.03  ? 649  ARG A NH1 1 
ATOM   2760 N  NH2 . ARG A 1 386 ? 0.719   -25.190 -46.929 0.50 56.57  ? 649  ARG A NH2 1 
ATOM   2761 N  N   . VAL A 1 387 ? -4.837  -26.978 -45.859 1.00 41.04  ? 650  VAL A N   1 
ATOM   2762 C  CA  . VAL A 1 387 ? -4.701  -28.355 -45.266 1.00 43.07  ? 650  VAL A CA  1 
ATOM   2763 C  C   . VAL A 1 387 ? -5.390  -28.540 -43.896 1.00 38.62  ? 650  VAL A C   1 
ATOM   2764 O  O   . VAL A 1 387 ? -5.302  -29.696 -43.397 1.00 33.78  ? 650  VAL A O   1 
ATOM   2765 C  CB  . VAL A 1 387 ? -3.215  -28.780 -45.178 1.00 37.49  ? 650  VAL A CB  1 
ATOM   2766 C  CG1 . VAL A 1 387 ? -2.557  -28.836 -46.546 1.00 39.79  ? 650  VAL A CG1 1 
ATOM   2767 C  CG2 . VAL A 1 387 ? -2.444  -27.911 -44.195 1.00 39.04  ? 650  VAL A CG2 1 
ATOM   2768 N  N   . GLY A 1 388 ? -6.040  -27.510 -43.343 1.00 34.70  ? 651  GLY A N   1 
ATOM   2769 C  CA  . GLY A 1 388 ? -6.633  -27.508 -41.982 1.00 36.25  ? 651  GLY A CA  1 
ATOM   2770 C  C   . GLY A 1 388 ? -7.543  -28.713 -41.774 1.00 35.54  ? 651  GLY A C   1 
ATOM   2771 O  O   . GLY A 1 388 ? -7.357  -29.453 -40.784 1.00 34.13  ? 651  GLY A O   1 
ATOM   2772 N  N   . ARG A 1 389 ? -8.439  -28.973 -42.714 1.00 33.78  ? 652  ARG A N   1 
ATOM   2773 C  CA  . ARG A 1 389 ? -9.424  -30.077 -42.579 1.00 36.57  ? 652  ARG A CA  1 
ATOM   2774 C  C   . ARG A 1 389 ? -8.664  -31.412 -42.628 1.00 35.50  ? 652  ARG A C   1 
ATOM   2775 O  O   . ARG A 1 389 ? -9.041  -32.319 -41.858 1.00 32.83  ? 652  ARG A O   1 
ATOM   2776 C  CB  . ARG A 1 389 ? -10.521 -30.001 -43.648 1.00 35.73  ? 652  ARG A CB  1 
ATOM   2777 C  CG  . ARG A 1 389 ? -11.465 -28.813 -43.483 1.00 39.34  ? 652  ARG A CG  1 
ATOM   2778 C  CD  . ARG A 1 389 ? -12.490 -28.815 -44.604 1.00 41.34  ? 652  ARG A CD  1 
ATOM   2779 N  NE  . ARG A 1 389 ? -13.450 -29.905 -44.485 1.00 43.07  ? 652  ARG A NE  1 
ATOM   2780 C  CZ  . ARG A 1 389 ? -14.494 -29.905 -43.634 1.00 42.05  ? 652  ARG A CZ  1 
ATOM   2781 N  NH1 . ARG A 1 389 ? -14.723 -28.870 -42.836 1.00 43.12  ? 652  ARG A NH1 1 
ATOM   2782 N  NH2 . ARG A 1 389 ? -15.299 -30.956 -43.586 1.00 43.35  ? 652  ARG A NH2 1 
ATOM   2783 N  N   . GLU A 1 390 ? -7.656  -31.571 -43.496 1.00 30.69  ? 653  GLU A N   1 
ATOM   2784 C  CA  . GLU A 1 390 ? -6.850  -32.828 -43.528 1.00 33.23  ? 653  GLU A CA  1 
ATOM   2785 C  C   . GLU A 1 390 ? -6.147  -33.013 -42.168 1.00 28.06  ? 653  GLU A C   1 
ATOM   2786 O  O   . GLU A 1 390 ? -6.153  -34.182 -41.675 1.00 29.21  ? 653  GLU A O   1 
ATOM   2787 C  CB  . GLU A 1 390 ? -5.836  -32.848 -44.689 1.00 34.68  ? 653  GLU A CB  1 
ATOM   2788 C  CG  . GLU A 1 390 ? -5.285  -34.219 -45.025 1.00 33.93  ? 653  GLU A CG  1 
ATOM   2789 C  CD  . GLU A 1 390 ? -4.132  -34.736 -44.155 1.00 36.25  ? 653  GLU A CD  1 
ATOM   2790 O  OE1 . GLU A 1 390 ? -3.545  -33.948 -43.378 1.00 38.68  ? 653  GLU A OE1 1 
ATOM   2791 O  OE2 . GLU A 1 390 ? -3.874  -35.955 -44.179 1.00 41.01  ? 653  GLU A OE2 1 
ATOM   2792 N  N   . ARG A 1 391 ? -5.647  -31.935 -41.557 1.00 26.74  ? 654  ARG A N   1 
ATOM   2793 C  CA  . ARG A 1 391 ? -4.862  -32.018 -40.301 1.00 29.04  ? 654  ARG A CA  1 
ATOM   2794 C  C   . ARG A 1 391 ? -5.816  -32.359 -39.135 1.00 29.05  ? 654  ARG A C   1 
ATOM   2795 O  O   . ARG A 1 391 ? -5.386  -33.082 -38.188 1.00 24.32  ? 654  ARG A O   1 
ATOM   2796 C  CB  . ARG A 1 391 ? -4.042  -30.741 -40.131 1.00 30.92  ? 654  ARG A CB  1 
ATOM   2797 C  CG  . ARG A 1 391 ? -3.010  -30.505 -41.234 1.00 33.54  ? 654  ARG A CG  1 
ATOM   2798 C  CD  . ARG A 1 391 ? -1.999  -31.625 -41.349 1.00 36.15  ? 654  ARG A CD  1 
ATOM   2799 N  NE  . ARG A 1 391 ? -0.887  -31.174 -42.142 1.00 35.43  ? 654  ARG A NE  1 
ATOM   2800 C  CZ  . ARG A 1 391 ? -0.775  -31.341 -43.454 1.00 39.67  ? 654  ARG A CZ  1 
ATOM   2801 N  NH1 . ARG A 1 391 ? -1.658  -32.020 -44.167 1.00 39.18  ? 654  ARG A NH1 1 
ATOM   2802 N  NH2 . ARG A 1 391 ? 0.271   -30.835 -44.066 1.00 47.02  ? 654  ARG A NH2 1 
ATOM   2803 N  N   . LEU A 1 392 ? -7.068  -31.903 -39.189 1.00 27.90  ? 655  LEU A N   1 
ATOM   2804 C  CA  . LEU A 1 392 ? -8.082  -32.233 -38.147 1.00 26.91  ? 655  LEU A CA  1 
ATOM   2805 C  C   . LEU A 1 392 ? -8.372  -33.736 -38.194 1.00 28.59  ? 655  LEU A C   1 
ATOM   2806 O  O   . LEU A 1 392 ? -8.521  -34.349 -37.155 1.00 26.85  ? 655  LEU A O   1 
ATOM   2807 C  CB  . LEU A 1 392 ? -9.380  -31.452 -38.357 1.00 31.08  ? 655  LEU A CB  1 
ATOM   2808 C  CG  . LEU A 1 392 ? -9.368  -29.959 -38.044 1.00 26.90  ? 655  LEU A CG  1 
ATOM   2809 C  CD1 . LEU A 1 392 ? -10.740 -29.402 -38.408 1.00 28.70  ? 655  LEU A CD1 1 
ATOM   2810 C  CD2 . LEU A 1 392 ? -9.010  -29.660 -36.591 1.00 26.14  ? 655  LEU A CD2 1 
ATOM   2811 N  N   . SER A 1 393 ? -8.405  -34.294 -39.405 0.50 29.04  ? 656  SER A N   1 
ATOM   2812 C  CA  . SER A 1 393 ? -8.712  -35.715 -39.690 0.50 29.77  ? 656  SER A CA  1 
ATOM   2813 C  C   . SER A 1 393 ? -7.625  -36.623 -39.109 0.50 29.25  ? 656  SER A C   1 
ATOM   2814 O  O   . SER A 1 393 ? -7.906  -37.808 -38.924 0.50 27.37  ? 656  SER A O   1 
ATOM   2815 C  CB  . SER A 1 393 ? -8.904  -35.929 -41.175 0.50 32.05  ? 656  SER A CB  1 
ATOM   2816 O  OG  . SER A 1 393 ? -7.737  -35.574 -41.915 0.50 32.46  ? 656  SER A OG  1 
ATOM   2817 N  N   . ARG A 1 394 ? -6.430  -36.083 -38.831 0.50 28.68  ? 657  ARG A N   1 
ATOM   2818 C  CA  . ARG A 1 394 ? -5.270  -36.840 -38.294 0.50 27.68  ? 657  ARG A CA  1 
ATOM   2819 C  C   . ARG A 1 394 ? -5.367  -36.918 -36.766 0.50 26.06  ? 657  ARG A C   1 
ATOM   2820 O  O   . ARG A 1 394 ? -4.371  -37.321 -36.138 0.50 25.78  ? 657  ARG A O   1 
ATOM   2821 C  CB  . ARG A 1 394 ? -3.951  -36.150 -38.664 0.50 28.95  ? 657  ARG A CB  1 
ATOM   2822 C  CG  . ARG A 1 394 ? -3.558  -36.248 -40.131 0.50 29.88  ? 657  ARG A CG  1 
ATOM   2823 C  CD  . ARG A 1 394 ? -2.326  -35.408 -40.428 0.50 30.70  ? 657  ARG A CD  1 
ATOM   2824 N  NE  . ARG A 1 394 ? -1.757  -35.793 -41.707 0.50 30.18  ? 657  ARG A NE  1 
ATOM   2825 C  CZ  . ARG A 1 394 ? -0.908  -36.788 -41.883 0.50 32.95  ? 657  ARG A CZ  1 
ATOM   2826 N  NH1 . ARG A 1 394 ? -0.477  -37.492 -40.848 0.50 30.13  ? 657  ARG A NH1 1 
ATOM   2827 N  NH2 . ARG A 1 394 ? -0.482  -37.068 -43.102 0.50 36.55  ? 657  ARG A NH2 1 
ATOM   2828 N  N   . MET A 1 395 ? -6.483  -36.475 -36.182 1.00 24.47  ? 658  MET A N   1 
ATOM   2829 C  CA  . MET A 1 395 ? -6.652  -36.456 -34.715 1.00 23.57  ? 658  MET A CA  1 
ATOM   2830 C  C   . MET A 1 395 ? -7.969  -37.112 -34.268 1.00 25.92  ? 658  MET A C   1 
ATOM   2831 O  O   . MET A 1 395 ? -8.974  -37.147 -34.998 1.00 21.89  ? 658  MET A O   1 
ATOM   2832 C  CB  . MET A 1 395 ? -6.529  -35.025 -34.205 1.00 25.18  ? 658  MET A CB  1 
ATOM   2833 C  CG  . MET A 1 395 ? -5.283  -34.309 -34.752 1.00 28.44  ? 658  MET A CG  1 
ATOM   2834 S  SD  . MET A 1 395 ? -4.920  -32.747 -33.972 1.00 26.74  ? 658  MET A SD  1 
ATOM   2835 C  CE  . MET A 1 395 ? -6.259  -31.706 -34.555 1.00 26.31  ? 658  MET A CE  1 
ATOM   2836 N  N   . ALA A 1 396 ? -7.927  -37.630 -33.052 1.00 22.10  ? 659  ALA A N   1 
ATOM   2837 C  CA  . ALA A 1 396 ? -9.085  -38.041 -32.271 1.00 22.38  ? 659  ALA A CA  1 
ATOM   2838 C  C   . ALA A 1 396 ? -8.988  -37.350 -30.910 1.00 23.57  ? 659  ALA A C   1 
ATOM   2839 O  O   . ALA A 1 396 ? -8.024  -37.515 -30.213 1.00 22.17  ? 659  ALA A O   1 
ATOM   2840 C  CB  . ALA A 1 396 ? -9.130  -39.553 -32.168 1.00 22.58  ? 659  ALA A CB  1 
ATOM   2841 N  N   . ILE A 1 397 ? -9.944  -36.483 -30.641 1.00 22.66  ? 660  ILE A N   1 
ATOM   2842 C  CA  . ILE A 1 397 ? -9.947  -35.590 -29.475 1.00 22.25  ? 660  ILE A CA  1 
ATOM   2843 C  C   . ILE A 1 397 ? -11.291 -35.688 -28.748 1.00 25.47  ? 660  ILE A C   1 
ATOM   2844 O  O   . ILE A 1 397 ? -12.349 -35.400 -29.333 1.00 22.00  ? 660  ILE A O   1 
ATOM   2845 C  CB  . ILE A 1 397 ? -9.642  -34.177 -29.950 1.00 25.86  ? 660  ILE A CB  1 
ATOM   2846 C  CG1 . ILE A 1 397 ? -8.343  -34.173 -30.776 1.00 28.20  ? 660  ILE A CG1 1 
ATOM   2847 C  CG2 . ILE A 1 397 ? -9.642  -33.280 -28.732 1.00 24.47  ? 660  ILE A CG2 1 
ATOM   2848 C  CD1 . ILE A 1 397 ? -7.741  -32.809 -31.087 1.00 30.67  ? 660  ILE A CD1 1 
ATOM   2849 N  N   . SER A 1 398 ? -11.178 -35.994 -27.469 1.00 23.55  ? 661  SER A N   1 
ATOM   2850 C  CA  . SER A 1 398 ? -12.281 -36.173 -26.516 1.00 25.69  ? 661  SER A CA  1 
ATOM   2851 C  C   . SER A 1 398 ? -11.985 -35.294 -25.323 1.00 25.56  ? 661  SER A C   1 
ATOM   2852 O  O   . SER A 1 398 ? -11.174 -35.727 -24.488 1.00 25.66  ? 661  SER A O   1 
ATOM   2853 C  CB  . SER A 1 398 ? -12.436 -37.596 -26.137 1.00 25.69  ? 661  SER A CB  1 
ATOM   2854 O  OG  . SER A 1 398 ? -13.678 -37.705 -25.518 1.00 27.04  ? 661  SER A OG  1 
ATOM   2855 N  N   . GLY A 1 399 ? -12.419 -34.032 -25.381 1.00 24.89  ? 662  GLY A N   1 
ATOM   2856 C  CA  . GLY A 1 399 ? -12.036 -33.100 -24.299 1.00 26.36  ? 662  GLY A CA  1 
ATOM   2857 C  C   . GLY A 1 399 ? -10.538 -32.953 -24.186 1.00 27.00  ? 662  GLY A C   1 
ATOM   2858 O  O   . GLY A 1 399 ? -9.876  -32.587 -25.198 1.00 28.28  ? 662  GLY A O   1 
ATOM   2859 N  N   . ASP A 1 400 ? -9.969  -33.165 -23.004 1.00 27.85  ? 663  ASP A N   1 
ATOM   2860 C  CA  . ASP A 1 400 ? -8.504  -32.969 -22.807 1.00 29.21  ? 663  ASP A CA  1 
ATOM   2861 C  C   . ASP A 1 400 ? -7.723  -34.177 -23.324 1.00 28.29  ? 663  ASP A C   1 
ATOM   2862 O  O   . ASP A 1 400 ? -6.496  -34.131 -23.341 1.00 26.66  ? 663  ASP A O   1 
ATOM   2863 C  CB  . ASP A 1 400 ? -8.184  -32.729 -21.332 1.00 32.71  ? 663  ASP A CB  1 
ATOM   2864 C  CG  . ASP A 1 400 ? -8.523  -33.877 -20.386 1.00 37.48  ? 663  ASP A CG  1 
ATOM   2865 O  OD1 . ASP A 1 400 ? -9.150  -34.844 -20.775 1.00 38.49  ? 663  ASP A OD1 1 
ATOM   2866 O  OD2 . ASP A 1 400 ? -8.139  -33.778 -19.254 1.00 42.92  ? 663  ASP A OD2 1 
ATOM   2867 N  N   . ASP A 1 401 ? -8.387  -35.174 -23.869 1.00 25.02  ? 664  ASP A N   1 
ATOM   2868 C  CA  . ASP A 1 401 ? -7.715  -36.426 -24.307 1.00 24.74  ? 664  ASP A CA  1 
ATOM   2869 C  C   . ASP A 1 401 ? -7.482  -36.338 -25.810 1.00 26.79  ? 664  ASP A C   1 
ATOM   2870 O  O   . ASP A 1 401 ? -8.444  -35.975 -26.527 1.00 29.65  ? 664  ASP A O   1 
ATOM   2871 C  CB  . ASP A 1 401 ? -8.541  -37.632 -23.847 1.00 26.13  ? 664  ASP A CB  1 
ATOM   2872 C  CG  . ASP A 1 401 ? -7.689  -38.880 -23.774 1.00 33.74  ? 664  ASP A CG  1 
ATOM   2873 O  OD1 . ASP A 1 401 ? -6.548  -38.730 -24.058 1.00 36.08  ? 664  ASP A OD1 1 
ATOM   2874 O  OD2 . ASP A 1 401 ? -8.193  -39.945 -23.514 1.00 37.40  ? 664  ASP A OD2 1 
ATOM   2875 N  N   . CYS A 1 402 ? -6.245  -36.545 -26.298 1.00 24.57  ? 665  CYS A N   1 
ATOM   2876 C  CA  . CYS A 1 402 ? -5.993  -36.569 -27.756 1.00 23.66  ? 665  CYS A CA  1 
ATOM   2877 C  C   . CYS A 1 402 ? -5.104  -37.726 -28.188 1.00 24.33  ? 665  CYS A C   1 
ATOM   2878 O  O   . CYS A 1 402 ? -4.193  -38.165 -27.440 1.00 26.44  ? 665  CYS A O   1 
ATOM   2879 C  CB  . CYS A 1 402 ? -5.376  -35.263 -28.234 1.00 29.51  ? 665  CYS A CB  1 
ATOM   2880 S  SG  . CYS A 1 402 ? -3.768  -34.937 -27.469 1.00 36.52  ? 665  CYS A SG  1 
ATOM   2881 N  N   . VAL A 1 403 ? -5.285  -38.076 -29.441 1.00 23.19  ? 666  VAL A N   1 
ATOM   2882 C  CA  . VAL A 1 403 ? -4.361  -38.884 -30.263 1.00 26.78  ? 666  VAL A CA  1 
ATOM   2883 C  C   . VAL A 1 403 ? -4.160  -38.108 -31.572 1.00 26.41  ? 666  VAL A C   1 
ATOM   2884 O  O   . VAL A 1 403 ? -5.166  -37.616 -32.137 1.00 25.48  ? 666  VAL A O   1 
ATOM   2885 C  CB  . VAL A 1 403 ? -4.944  -40.284 -30.501 1.00 26.43  ? 666  VAL A CB  1 
ATOM   2886 C  CG1 . VAL A 1 403 ? -4.057  -41.125 -31.390 1.00 26.71  ? 666  VAL A CG1 1 
ATOM   2887 C  CG2 . VAL A 1 403 ? -5.264  -40.958 -29.176 1.00 26.55  ? 666  VAL A CG2 1 
ATOM   2888 N  N   . VAL A 1 404 ? -2.901  -37.935 -31.965 1.00 23.80  ? 667  VAL A N   1 
ATOM   2889 C  CA  . VAL A 1 404 ? -2.477  -37.186 -33.173 1.00 23.75  ? 667  VAL A CA  1 
ATOM   2890 C  C   . VAL A 1 404 ? -1.542  -38.050 -34.000 1.00 22.79  ? 667  VAL A C   1 
ATOM   2891 O  O   . VAL A 1 404 ? -0.530  -38.539 -33.465 1.00 27.01  ? 667  VAL A O   1 
ATOM   2892 C  CB  . VAL A 1 404 ? -1.793  -35.846 -32.829 1.00 25.75  ? 667  VAL A CB  1 
ATOM   2893 C  CG1 . VAL A 1 404 ? -1.457  -35.076 -34.109 1.00 26.38  ? 667  VAL A CG1 1 
ATOM   2894 C  CG2 . VAL A 1 404 ? -2.631  -34.973 -31.894 1.00 29.64  ? 667  VAL A CG2 1 
ATOM   2895 N  N   . LYS A 1 405 ? -1.819  -38.208 -35.280 1.00 25.18  ? 668  LYS A N   1 
ATOM   2896 C  CA  . LYS A 1 405 ? -0.851  -38.799 -36.247 1.00 26.09  ? 668  LYS A CA  1 
ATOM   2897 C  C   . LYS A 1 405 ? -0.368  -37.685 -37.182 1.00 30.35  ? 668  LYS A C   1 
ATOM   2898 O  O   . LYS A 1 405 ? -0.938  -37.459 -38.242 1.00 25.09  ? 668  LYS A O   1 
ATOM   2899 C  CB  . LYS A 1 405 ? -1.404  -39.921 -37.109 1.00 27.55  ? 668  LYS A CB  1 
ATOM   2900 C  CG  . LYS A 1 405 ? -0.262  -40.690 -37.757 1.00 29.86  ? 668  LYS A CG  1 
ATOM   2901 C  CD  . LYS A 1 405 ? -0.596  -41.919 -38.518 1.00 32.95  ? 668  LYS A CD  1 
ATOM   2902 C  CE  . LYS A 1 405 ? 0.671   -42.411 -39.211 1.00 35.40  ? 668  LYS A CE  1 
ATOM   2903 N  NZ  . LYS A 1 405 ? 0.540   -43.781 -39.691 1.00 40.72  ? 668  LYS A NZ  1 
ATOM   2904 N  N   . PRO A 1 406 ? 0.697   -36.962 -36.800 1.00 30.15  ? 669  PRO A N   1 
ATOM   2905 C  CA  . PRO A 1 406 ? 1.197   -35.840 -37.598 1.00 28.62  ? 669  PRO A CA  1 
ATOM   2906 C  C   . PRO A 1 406 ? 1.820   -36.306 -38.913 1.00 25.94  ? 669  PRO A C   1 
ATOM   2907 O  O   . PRO A 1 406 ? 2.066   -37.497 -39.155 1.00 28.01  ? 669  PRO A O   1 
ATOM   2908 C  CB  . PRO A 1 406 ? 2.203   -35.196 -36.637 1.00 26.33  ? 669  PRO A CB  1 
ATOM   2909 C  CG  . PRO A 1 406 ? 2.758   -36.379 -35.884 1.00 27.90  ? 669  PRO A CG  1 
ATOM   2910 C  CD  . PRO A 1 406 ? 1.518   -37.210 -35.613 1.00 28.23  ? 669  PRO A CD  1 
ATOM   2911 N  N   . LEU A 1 407 ? 2.110   -35.334 -39.767 1.00 29.39  ? 670  LEU A N   1 
ATOM   2912 C  CA  . LEU A 1 407 ? 2.765   -35.554 -41.081 1.00 32.33  ? 670  LEU A CA  1 
ATOM   2913 C  C   . LEU A 1 407 ? 4.117   -36.294 -40.893 1.00 27.89  ? 670  LEU A C   1 
ATOM   2914 O  O   . LEU A 1 407 ? 4.416   -37.122 -41.737 1.00 32.28  ? 670  LEU A O   1 
ATOM   2915 C  CB  . LEU A 1 407 ? 2.910   -34.169 -41.743 1.00 34.88  ? 670  LEU A CB  1 
ATOM   2916 C  CG  . LEU A 1 407 ? 3.085   -34.143 -43.253 1.00 43.77  ? 670  LEU A CG  1 
ATOM   2917 C  CD1 . LEU A 1 407 ? 1.807   -34.553 -43.976 1.00 43.09  ? 670  LEU A CD1 1 
ATOM   2918 C  CD2 . LEU A 1 407 ? 3.527   -32.746 -43.682 1.00 48.20  ? 670  LEU A CD2 1 
ATOM   2919 N  N   . ASP A 1 408 ? 4.848   -36.070 -39.794 1.00 29.28  ? 671  ASP A N   1 
ATOM   2920 C  CA  . ASP A 1 408 ? 6.154   -36.734 -39.534 1.00 33.21  ? 671  ASP A CA  1 
ATOM   2921 C  C   . ASP A 1 408 ? 6.523   -36.547 -38.072 1.00 30.45  ? 671  ASP A C   1 
ATOM   2922 O  O   . ASP A 1 408 ? 5.788   -35.882 -37.334 1.00 36.62  ? 671  ASP A O   1 
ATOM   2923 C  CB  . ASP A 1 408 ? 7.212   -36.236 -40.549 1.00 35.92  ? 671  ASP A CB  1 
ATOM   2924 C  CG  . ASP A 1 408 ? 7.290   -34.720 -40.586 1.00 33.11  ? 671  ASP A CG  1 
ATOM   2925 O  OD1 . ASP A 1 408 ? 7.558   -34.151 -39.517 1.00 31.38  ? 671  ASP A OD1 1 
ATOM   2926 O  OD2 . ASP A 1 408 ? 6.962   -34.115 -41.655 1.00 37.35  ? 671  ASP A OD2 1 
ATOM   2927 N  N   . ASP A 1 409 ? 7.671   -37.056 -37.659 1.00 27.74  ? 672  ASP A N   1 
ATOM   2928 C  CA  . ASP A 1 409 ? 8.050   -37.028 -36.230 1.00 28.20  ? 672  ASP A CA  1 
ATOM   2929 C  C   . ASP A 1 409 ? 8.727   -35.720 -35.830 1.00 29.21  ? 672  ASP A C   1 
ATOM   2930 O  O   . ASP A 1 409 ? 9.046   -35.585 -34.642 1.00 29.00  ? 672  ASP A O   1 
ATOM   2931 C  CB  . ASP A 1 409 ? 8.809   -38.302 -35.901 1.00 33.99  ? 672  ASP A CB  1 
ATOM   2932 C  CG  . ASP A 1 409 ? 7.918   -39.524 -36.037 1.00 35.28  ? 672  ASP A CG  1 
ATOM   2933 O  OD1 . ASP A 1 409 ? 6.799   -39.482 -35.483 1.00 35.49  ? 672  ASP A OD1 1 
ATOM   2934 O  OD2 . ASP A 1 409 ? 8.335   -40.474 -36.700 1.00 36.79  ? 672  ASP A OD2 1 
ATOM   2935 N  N   . ARG A 1 410 ? 8.776   -34.691 -36.675 1.00 31.12  ? 673  ARG A N   1 
ATOM   2936 C  CA  . ARG A 1 410 ? 9.237   -33.361 -36.144 1.00 32.79  ? 673  ARG A CA  1 
ATOM   2937 C  C   . ARG A 1 410 ? 8.305   -32.888 -35.017 1.00 33.40  ? 673  ARG A C   1 
ATOM   2938 O  O   . ARG A 1 410 ? 8.753   -32.161 -34.150 1.00 32.48  ? 673  ARG A O   1 
ATOM   2939 C  CB  . ARG A 1 410 ? 9.276   -32.288 -37.240 1.00 37.34  ? 673  ARG A CB  1 
ATOM   2940 C  CG  . ARG A 1 410 ? 10.366  -32.473 -38.288 1.00 37.07  ? 673  ARG A CG  1 
ATOM   2941 C  CD  . ARG A 1 410 ? 10.192  -31.445 -39.387 1.00 35.39  ? 673  ARG A CD  1 
ATOM   2942 N  NE  . ARG A 1 410 ? 9.022   -31.738 -40.201 1.00 34.55  ? 673  ARG A NE  1 
ATOM   2943 C  CZ  . ARG A 1 410 ? 8.523   -30.939 -41.136 1.00 37.87  ? 673  ARG A CZ  1 
ATOM   2944 N  NH1 . ARG A 1 410 ? 9.099   -29.769 -41.388 1.00 33.43  ? 673  ARG A NH1 1 
ATOM   2945 N  NH2 . ARG A 1 410 ? 7.474   -31.340 -41.842 1.00 36.09  ? 673  ARG A NH2 1 
ATOM   2946 N  N   . PHE A 1 411 ? 7.021   -33.302 -35.034 1.00 31.62  ? 674  PHE A N   1 
ATOM   2947 C  CA  . PHE A 1 411 ? 5.977   -33.027 -34.015 1.00 25.57  ? 674  PHE A CA  1 
ATOM   2948 C  C   . PHE A 1 411 ? 6.471   -33.360 -32.618 1.00 24.32  ? 674  PHE A C   1 
ATOM   2949 O  O   . PHE A 1 411 ? 6.209   -32.566 -31.696 1.00 31.37  ? 674  PHE A O   1 
ATOM   2950 C  CB  . PHE A 1 411 ? 4.716   -33.836 -34.372 1.00 27.59  ? 674  PHE A CB  1 
ATOM   2951 C  CG  . PHE A 1 411 ? 3.544   -33.679 -33.443 1.00 28.51  ? 674  PHE A CG  1 
ATOM   2952 C  CD1 . PHE A 1 411 ? 3.418   -34.478 -32.319 1.00 27.27  ? 674  PHE A CD1 1 
ATOM   2953 C  CD2 . PHE A 1 411 ? 2.520   -32.799 -33.743 1.00 29.37  ? 674  PHE A CD2 1 
ATOM   2954 C  CE1 . PHE A 1 411 ? 2.301   -34.364 -31.501 1.00 30.03  ? 674  PHE A CE1 1 
ATOM   2955 C  CE2 . PHE A 1 411 ? 1.419   -32.660 -32.905 1.00 26.10  ? 674  PHE A CE2 1 
ATOM   2956 C  CZ  . PHE A 1 411 ? 1.311   -33.430 -31.774 1.00 28.38  ? 674  PHE A CZ  1 
ATOM   2957 N  N   . ALA A 1 412 ? 7.215   -34.472 -32.452 1.00 27.23  ? 675  ALA A N   1 
ATOM   2958 C  CA  . ALA A 1 412 ? 7.711   -34.987 -31.160 1.00 28.97  ? 675  ALA A CA  1 
ATOM   2959 C  C   . ALA A 1 412 ? 8.477   -33.909 -30.364 1.00 33.25  ? 675  ALA A C   1 
ATOM   2960 O  O   . ALA A 1 412 ? 8.318   -33.834 -29.134 1.00 26.96  ? 675  ALA A O   1 
ATOM   2961 C  CB  . ALA A 1 412 ? 8.544   -36.234 -31.421 1.00 31.54  ? 675  ALA A CB  1 
ATOM   2962 N  N   . SER A 1 413 ? 9.249   -33.041 -31.031 1.00 33.12  ? 676  SER A N   1 
ATOM   2963 C  CA  . SER A 1 413 ? 10.068  -32.013 -30.341 1.00 33.82  ? 676  SER A CA  1 
ATOM   2964 C  C   . SER A 1 413 ? 9.550   -30.615 -30.653 1.00 38.34  ? 676  SER A C   1 
ATOM   2965 O  O   . SER A 1 413 ? 10.281  -29.673 -30.392 1.00 36.42  ? 676  SER A O   1 
ATOM   2966 C  CB  . SER A 1 413 ? 11.563  -32.152 -30.700 1.00 37.86  ? 676  SER A CB  1 
ATOM   2967 O  OG  . SER A 1 413 ? 11.705  -32.241 -32.106 1.00 39.06  ? 676  SER A OG  1 
ATOM   2968 N  N   . ALA A 1 414 ? 8.323   -30.459 -31.168 1.00 37.43  ? 677  ALA A N   1 
ATOM   2969 C  CA  . ALA A 1 414 ? 7.723   -29.122 -31.400 1.00 37.55  ? 677  ALA A CA  1 
ATOM   2970 C  C   . ALA A 1 414 ? 6.952   -28.739 -30.140 1.00 37.61  ? 677  ALA A C   1 
ATOM   2971 O  O   . ALA A 1 414 ? 5.741   -29.105 -30.032 1.00 39.95  ? 677  ALA A O   1 
ATOM   2972 C  CB  . ALA A 1 414 ? 6.851   -29.173 -32.621 1.00 34.17  ? 677  ALA A CB  1 
ATOM   2973 N  N   . LEU A 1 415 ? 7.628   -28.144 -29.167 1.00 32.79  ? 678  LEU A N   1 
ATOM   2974 C  CA  . LEU A 1 415 ? 7.120   -28.017 -27.782 1.00 32.79  ? 678  LEU A CA  1 
ATOM   2975 C  C   . LEU A 1 415 ? 6.940   -26.554 -27.379 1.00 31.66  ? 678  LEU A C   1 
ATOM   2976 O  O   . LEU A 1 415 ? 6.326   -26.345 -26.321 1.00 40.07  ? 678  LEU A O   1 
ATOM   2977 C  CB  . LEU A 1 415 ? 8.039   -28.752 -26.814 1.00 31.28  ? 678  LEU A CB  1 
ATOM   2978 C  CG  . LEU A 1 415 ? 8.133   -30.267 -27.057 1.00 35.55  ? 678  LEU A CG  1 
ATOM   2979 C  CD1 . LEU A 1 415 ? 9.292   -30.896 -26.284 1.00 34.20  ? 678  LEU A CD1 1 
ATOM   2980 C  CD2 . LEU A 1 415 ? 6.817   -30.954 -26.729 1.00 37.27  ? 678  LEU A CD2 1 
ATOM   2981 N  N   . THR A 1 416 ? 7.394   -25.587 -28.166 1.00 35.12  ? 679  THR A N   1 
ATOM   2982 C  CA  . THR A 1 416 ? 7.455   -24.180 -27.675 1.00 35.75  ? 679  THR A CA  1 
ATOM   2983 C  C   . THR A 1 416 ? 6.024   -23.617 -27.541 1.00 33.83  ? 679  THR A C   1 
ATOM   2984 O  O   . THR A 1 416 ? 5.685   -23.111 -26.445 1.00 35.04  ? 679  THR A O   1 
ATOM   2985 C  CB  . THR A 1 416 ? 8.359   -23.306 -28.547 1.00 34.55  ? 679  THR A CB  1 
ATOM   2986 O  OG1 . THR A 1 416 ? 7.869   -23.181 -29.881 1.00 41.01  ? 679  THR A OG1 1 
ATOM   2987 C  CG2 . THR A 1 416 ? 9.781   -23.826 -28.628 1.00 38.54  ? 679  THR A CG2 1 
ATOM   2988 N  N   . ALA A 1 417 ? 5.193   -23.718 -28.587 1.00 33.95  ? 680  ALA A N   1 
ATOM   2989 C  CA  . ALA A 1 417 ? 3.781   -23.239 -28.532 1.00 34.69  ? 680  ALA A CA  1 
ATOM   2990 C  C   . ALA A 1 417 ? 3.009   -24.033 -27.466 1.00 38.94  ? 680  ALA A C   1 
ATOM   2991 O  O   . ALA A 1 417 ? 2.330   -23.376 -26.595 1.00 37.11  ? 680  ALA A O   1 
ATOM   2992 C  CB  . ALA A 1 417 ? 3.158   -23.293 -29.893 1.00 36.26  ? 680  ALA A CB  1 
ATOM   2993 N  N   . LEU A 1 418 ? 3.176   -25.369 -27.420 1.00 35.10  ? 681  LEU A N   1 
ATOM   2994 C  CA  . LEU A 1 418 ? 2.399   -26.187 -26.466 1.00 33.07  ? 681  LEU A CA  1 
ATOM   2995 C  C   . LEU A 1 418 ? 2.714   -25.737 -25.042 1.00 34.59  ? 681  LEU A C   1 
ATOM   2996 O  O   . LEU A 1 418 ? 1.768   -25.605 -24.222 1.00 33.98  ? 681  LEU A O   1 
ATOM   2997 C  CB  . LEU A 1 418 ? 2.723   -27.670 -26.694 1.00 37.99  ? 681  LEU A CB  1 
ATOM   2998 C  CG  . LEU A 1 418 ? 1.900   -28.648 -25.868 1.00 37.19  ? 681  LEU A CG  1 
ATOM   2999 C  CD1 . LEU A 1 418 ? 0.473   -28.701 -26.394 1.00 38.07  ? 681  LEU A CD1 1 
ATOM   3000 C  CD2 . LEU A 1 418 ? 2.533   -30.031 -25.888 1.00 37.19  ? 681  LEU A CD2 1 
ATOM   3001 N  N   . ASN A 1 419 ? 4.008   -25.548 -24.723 1.00 37.02  ? 682  ASN A N   1 
ATOM   3002 C  CA  . ASN A 1 419 ? 4.441   -25.180 -23.358 1.00 36.34  ? 682  ASN A CA  1 
ATOM   3003 C  C   . ASN A 1 419 ? 3.967   -23.744 -23.094 1.00 33.06  ? 682  ASN A C   1 
ATOM   3004 O  O   . ASN A 1 419 ? 3.457   -23.480 -22.001 1.00 35.52  ? 682  ASN A O   1 
ATOM   3005 C  CB  . ASN A 1 419 ? 5.946   -25.426 -23.166 1.00 42.53  ? 682  ASN A CB  1 
ATOM   3006 C  CG  . ASN A 1 419 ? 6.304   -26.873 -22.840 1.00 42.80  ? 682  ASN A CG  1 
ATOM   3007 O  OD1 . ASN A 1 419 ? 5.510   -27.623 -22.267 1.00 36.71  ? 682  ASN A OD1 1 
ATOM   3008 N  ND2 . ASN A 1 419 ? 7.521   -27.275 -23.154 1.00 39.53  ? 682  ASN A ND2 1 
ATOM   3009 N  N   . ASP A 1 420 ? 4.094   -22.849 -24.063 1.00 32.47  ? 683  ASP A N   1 
ATOM   3010 C  CA  . ASP A 1 420 ? 3.769   -21.407 -23.841 1.00 38.54  ? 683  ASP A CA  1 
ATOM   3011 C  C   . ASP A 1 420 ? 2.242   -21.183 -23.761 1.00 40.49  ? 683  ASP A C   1 
ATOM   3012 O  O   . ASP A 1 420 ? 1.828   -20.287 -23.009 1.00 40.98  ? 683  ASP A O   1 
ATOM   3013 C  CB  . ASP A 1 420 ? 4.340   -20.515 -24.942 1.00 36.35  ? 683  ASP A CB  1 
ATOM   3014 C  CG  . ASP A 1 420 ? 4.273   -19.024 -24.593 1.00 38.83  ? 683  ASP A CG  1 
ATOM   3015 O  OD1 . ASP A 1 420 ? 4.624   -18.675 -23.449 1.00 40.71  ? 683  ASP A OD1 1 
ATOM   3016 O  OD2 . ASP A 1 420 ? 3.839   -18.233 -25.464 1.00 39.30  ? 683  ASP A OD2 1 
ATOM   3017 N  N   . MET A 1 421 ? 1.420   -22.005 -24.426 1.00 41.17  ? 684  MET A N   1 
ATOM   3018 C  CA  . MET A 1 421 ? -0.065  -21.978 -24.246 1.00 37.37  ? 684  MET A CA  1 
ATOM   3019 C  C   . MET A 1 421 ? -0.427  -22.473 -22.839 1.00 39.94  ? 684  MET A C   1 
ATOM   3020 O  O   . MET A 1 421 ? -1.573  -22.295 -22.436 1.00 41.51  ? 684  MET A O   1 
ATOM   3021 C  CB  . MET A 1 421 ? -0.788  -22.804 -25.317 1.00 38.90  ? 684  MET A CB  1 
ATOM   3022 C  CG  . MET A 1 421 ? -0.617  -22.247 -26.695 1.00 38.23  ? 684  MET A CG  1 
ATOM   3023 S  SD  . MET A 1 421 ? -1.505  -23.174 -28.019 1.00 40.87  ? 684  MET A SD  1 
ATOM   3024 C  CE  . MET A 1 421 ? -0.634  -24.740 -28.066 1.00 46.94  ? 684  MET A CE  1 
ATOM   3025 N  N   . GLY A 1 422 ? 0.520   -23.051 -22.093 1.00 39.03  ? 685  GLY A N   1 
ATOM   3026 C  CA  . GLY A 1 422 ? 0.307   -23.619 -20.742 1.00 32.82  ? 685  GLY A CA  1 
ATOM   3027 C  C   . GLY A 1 422 ? -0.116  -25.085 -20.740 1.00 33.56  ? 685  GLY A C   1 
ATOM   3028 O  O   . GLY A 1 422 ? -0.368  -25.634 -19.647 1.00 34.93  ? 685  GLY A O   1 
ATOM   3029 N  N   . LYS A 1 423 ? -0.197  -25.739 -21.884 1.00 30.82  ? 686  LYS A N   1 
ATOM   3030 C  CA  . LYS A 1 423 ? -0.650  -27.164 -21.965 1.00 36.87  ? 686  LYS A CA  1 
ATOM   3031 C  C   . LYS A 1 423 ? 0.549   -28.112 -21.747 1.00 37.39  ? 686  LYS A C   1 
ATOM   3032 O  O   . LYS A 1 423 ? 0.881   -28.953 -22.650 1.00 35.69  ? 686  LYS A O   1 
ATOM   3033 C  CB  . LYS A 1 423 ? -1.406  -27.343 -23.277 1.00 33.09  ? 686  LYS A CB  1 
ATOM   3034 C  CG  . LYS A 1 423 ? -2.531  -26.330 -23.451 1.00 33.36  ? 686  LYS A CG  1 
ATOM   3035 C  CD  . LYS A 1 423 ? -3.448  -26.300 -22.223 1.00 35.89  ? 686  LYS A CD  1 
ATOM   3036 C  CE  . LYS A 1 423 ? -4.652  -25.386 -22.367 1.00 43.00  ? 686  LYS A CE  1 
ATOM   3037 N  NZ  . LYS A 1 423 ? -4.263  -23.950 -22.352 1.00 44.55  ? 686  LYS A NZ  1 
ATOM   3038 N  N   . VAL A 1 424 ? 1.185   -27.989 -20.579 0.50 37.77  ? 687  VAL A N   1 
ATOM   3039 C  CA  . VAL A 1 424 ? 2.420   -28.739 -20.205 0.50 38.69  ? 687  VAL A CA  1 
ATOM   3040 C  C   . VAL A 1 424 ? 2.068   -30.225 -20.065 0.50 35.70  ? 687  VAL A C   1 
ATOM   3041 O  O   . VAL A 1 424 ? 1.059   -30.547 -19.400 0.50 37.59  ? 687  VAL A O   1 
ATOM   3042 C  CB  . VAL A 1 424 ? 3.061   -28.157 -18.927 0.50 42.54  ? 687  VAL A CB  1 
ATOM   3043 C  CG1 . VAL A 1 424 ? 4.213   -29.009 -18.418 0.50 45.01  ? 687  VAL A CG1 1 
ATOM   3044 C  CG2 . VAL A 1 424 ? 3.523   -26.723 -19.139 0.50 43.74  ? 687  VAL A CG2 1 
ATOM   3045 N  N   . ARG A 1 425 ? 2.882   -31.084 -20.683 1.00 33.94  ? 688  ARG A N   1 
ATOM   3046 C  CA  . ARG A 1 425 ? 2.673   -32.547 -20.727 1.00 38.44  ? 688  ARG A CA  1 
ATOM   3047 C  C   . ARG A 1 425 ? 2.911   -33.144 -19.349 1.00 39.13  ? 688  ARG A C   1 
ATOM   3048 O  O   . ARG A 1 425 ? 3.787   -32.634 -18.619 1.00 43.98  ? 688  ARG A O   1 
ATOM   3049 C  CB  . ARG A 1 425 ? 3.585   -33.193 -21.760 1.00 33.67  ? 688  ARG A CB  1 
ATOM   3050 C  CG  . ARG A 1 425 ? 3.200   -32.830 -23.179 1.00 33.65  ? 688  ARG A CG  1 
ATOM   3051 C  CD  . ARG A 1 425 ? 4.313   -33.197 -24.113 1.00 35.32  ? 688  ARG A CD  1 
ATOM   3052 N  NE  . ARG A 1 425 ? 5.554   -32.557 -23.697 1.00 34.85  ? 688  ARG A NE  1 
ATOM   3053 C  CZ  . ARG A 1 425 ? 6.803   -32.979 -23.953 1.00 33.99  ? 688  ARG A CZ  1 
ATOM   3054 N  NH1 . ARG A 1 425 ? 7.048   -34.066 -24.673 1.00 32.92  ? 688  ARG A NH1 1 
ATOM   3055 N  NH2 . ARG A 1 425 ? 7.809   -32.261 -23.479 1.00 38.90  ? 688  ARG A NH2 1 
ATOM   3056 N  N   . LYS A 1 426 ? 2.196   -34.230 -19.054 0.50 39.55  ? 689  LYS A N   1 
ATOM   3057 C  CA  . LYS A 1 426 ? 2.314   -34.915 -17.748 0.50 41.40  ? 689  LYS A CA  1 
ATOM   3058 C  C   . LYS A 1 426 ? 3.377   -36.017 -17.809 0.50 42.34  ? 689  LYS A C   1 
ATOM   3059 O  O   . LYS A 1 426 ? 3.513   -36.639 -18.872 0.50 38.92  ? 689  LYS A O   1 
ATOM   3060 C  CB  . LYS A 1 426 ? 0.963   -35.542 -17.396 0.50 44.41  ? 689  LYS A CB  1 
ATOM   3061 C  CG  . LYS A 1 426 ? 0.911   -36.306 -16.081 0.50 50.16  ? 689  LYS A CG  1 
ATOM   3062 C  CD  . LYS A 1 426 ? -0.409  -37.007 -15.861 0.50 53.13  ? 689  LYS A CD  1 
ATOM   3063 C  CE  . LYS A 1 426 ? -0.730  -38.006 -16.952 0.50 57.87  ? 689  LYS A CE  1 
ATOM   3064 N  NZ  . LYS A 1 426 ? -2.014  -38.702 -16.702 0.50 60.69  ? 689  LYS A NZ  1 
ATOM   3065 N  N   . ASP A 1 427 ? 4.111   -36.230 -16.715 0.50 44.50  ? 690  ASP A N   1 
ATOM   3066 C  CA  . ASP A 1 427 ? 5.073   -37.365 -16.635 0.50 46.39  ? 690  ASP A CA  1 
ATOM   3067 C  C   . ASP A 1 427 ? 6.149   -37.282 -17.725 0.50 46.39  ? 690  ASP A C   1 
ATOM   3068 O  O   . ASP A 1 427 ? 6.456   -38.332 -18.314 0.50 46.86  ? 690  ASP A O   1 
ATOM   3069 C  CB  . ASP A 1 427 ? 4.317   -38.694 -16.654 0.50 47.78  ? 690  ASP A CB  1 
ATOM   3070 C  CG  . ASP A 1 427 ? 3.360   -38.846 -15.485 0.50 51.01  ? 690  ASP A CG  1 
ATOM   3071 O  OD1 . ASP A 1 427 ? 3.480   -38.057 -14.530 0.50 50.89  ? 690  ASP A OD1 1 
ATOM   3072 O  OD2 . ASP A 1 427 ? 2.502   -39.747 -15.544 0.50 57.38  ? 690  ASP A OD2 1 
ATOM   3073 N  N   . ILE A 1 428 ? 6.707   -36.095 -17.964 0.50 43.08  ? 691  ILE A N   1 
ATOM   3074 C  CA  . ILE A 1 428 ? 7.833   -35.950 -18.934 0.50 46.55  ? 691  ILE A CA  1 
ATOM   3075 C  C   . ILE A 1 428 ? 8.448   -34.569 -18.718 0.50 48.26  ? 691  ILE A C   1 
ATOM   3076 O  O   . ILE A 1 428 ? 7.696   -33.635 -18.407 0.50 50.52  ? 691  ILE A O   1 
ATOM   3077 C  CB  . ILE A 1 428 ? 7.385   -36.164 -20.396 0.50 45.63  ? 691  ILE A CB  1 
ATOM   3078 C  CG1 . ILE A 1 428 ? 8.583   -36.376 -21.325 0.50 45.58  ? 691  ILE A CG1 1 
ATOM   3079 C  CG2 . ILE A 1 428 ? 6.496   -35.026 -20.871 0.50 44.43  ? 691  ILE A CG2 1 
ATOM   3080 C  CD1 . ILE A 1 428 ? 8.208   -36.729 -22.742 0.50 44.90  ? 691  ILE A CD1 1 
ATOM   3081 N  N   . GLN A 1 429 ? 9.768   -34.463 -18.848 0.50 49.33  ? 692  GLN A N   1 
ATOM   3082 C  CA  . GLN A 1 429 ? 10.455  -33.158 -18.669 0.50 51.55  ? 692  GLN A CA  1 
ATOM   3083 C  C   . GLN A 1 429 ? 9.927   -32.179 -19.718 0.50 48.86  ? 692  GLN A C   1 
ATOM   3084 O  O   . GLN A 1 429 ? 9.690   -32.613 -20.854 0.50 45.81  ? 692  GLN A O   1 
ATOM   3085 C  CB  . GLN A 1 429 ? 11.974  -33.333 -18.722 0.50 56.05  ? 692  GLN A CB  1 
ATOM   3086 C  CG  . GLN A 1 429 ? 12.504  -34.314 -17.688 0.50 61.25  ? 692  GLN A CG  1 
ATOM   3087 C  CD  . GLN A 1 429 ? 13.670  -35.120 -18.206 0.50 65.83  ? 692  GLN A CD  1 
ATOM   3088 O  OE1 . GLN A 1 429 ? 14.444  -35.689 -17.441 0.50 68.06  ? 692  GLN A OE1 1 
ATOM   3089 N  NE2 . GLN A 1 429 ? 13.803  -35.174 -19.521 0.50 68.81  ? 692  GLN A NE2 1 
ATOM   3090 N  N   . GLN A 1 430 ? 9.800   -30.904 -19.358 0.50 51.12  ? 693  GLN A N   1 
ATOM   3091 C  CA  . GLN A 1 430 ? 9.177   -29.897 -20.258 0.50 52.27  ? 693  GLN A CA  1 
ATOM   3092 C  C   . GLN A 1 430 ? 9.765   -29.919 -21.668 0.50 50.75  ? 693  GLN A C   1 
ATOM   3093 O  O   . GLN A 1 430 ? 8.992   -29.692 -22.611 0.50 51.15  ? 693  GLN A O   1 
ATOM   3094 C  CB  . GLN A 1 430 ? 9.353   -28.499 -19.665 0.50 54.38  ? 693  GLN A CB  1 
ATOM   3095 C  CG  . GLN A 1 430 ? 8.119   -27.620 -19.795 0.50 54.79  ? 693  GLN A CG  1 
ATOM   3096 C  CD  . GLN A 1 430 ? 8.395   -26.202 -19.358 0.50 53.18  ? 693  GLN A CD  1 
ATOM   3097 O  OE1 . GLN A 1 430 ? 9.540   -25.806 -19.155 0.50 49.93  ? 693  GLN A OE1 1 
ATOM   3098 N  NE2 . GLN A 1 430 ? 7.336   -25.424 -19.206 0.50 50.79  ? 693  GLN A NE2 1 
ATOM   3099 N  N   . TRP A 1 431 ? 11.066  -30.167 -21.814 1.00 46.01  ? 694  TRP A N   1 
ATOM   3100 C  CA  . TRP A 1 431 ? 11.685  -30.048 -23.159 1.00 46.22  ? 694  TRP A CA  1 
ATOM   3101 C  C   . TRP A 1 431 ? 12.144  -31.398 -23.721 1.00 41.86  ? 694  TRP A C   1 
ATOM   3102 O  O   . TRP A 1 431 ? 12.788  -31.391 -24.771 1.00 44.58  ? 694  TRP A O   1 
ATOM   3103 C  CB  . TRP A 1 431 ? 12.804  -29.008 -23.108 1.00 52.50  ? 694  TRP A CB  1 
ATOM   3104 C  CG  . TRP A 1 431 ? 12.293  -27.666 -22.685 1.00 59.22  ? 694  TRP A CG  1 
ATOM   3105 C  CD1 . TRP A 1 431 ? 12.542  -27.018 -21.511 1.00 58.95  ? 694  TRP A CD1 1 
ATOM   3106 C  CD2 . TRP A 1 431 ? 11.402  -26.817 -23.429 1.00 54.44  ? 694  TRP A CD2 1 
ATOM   3107 N  NE1 . TRP A 1 431 ? 11.882  -25.820 -21.481 1.00 65.42  ? 694  TRP A NE1 1 
ATOM   3108 C  CE2 . TRP A 1 431 ? 11.174  -25.670 -22.643 1.00 58.55  ? 694  TRP A CE2 1 
ATOM   3109 C  CE3 . TRP A 1 431 ? 10.786  -26.910 -24.680 1.00 51.13  ? 694  TRP A CE3 1 
ATOM   3110 C  CZ2 . TRP A 1 431 ? 10.354  -24.628 -23.070 1.00 58.51  ? 694  TRP A CZ2 1 
ATOM   3111 C  CZ3 . TRP A 1 431 ? 9.978   -25.880 -25.102 1.00 56.50  ? 694  TRP A CZ3 1 
ATOM   3112 C  CH2 . TRP A 1 431 ? 9.765   -24.756 -24.306 1.00 55.30  ? 694  TRP A CH2 1 
ATOM   3113 N  N   . GLU A 1 432 ? 11.791  -32.496 -23.062 1.00 41.18  ? 695  GLU A N   1 
ATOM   3114 C  CA  . GLU A 1 432 ? 12.109  -33.846 -23.588 1.00 44.39  ? 695  GLU A CA  1 
ATOM   3115 C  C   . GLU A 1 432 ? 11.102  -34.178 -24.691 1.00 46.33  ? 695  GLU A C   1 
ATOM   3116 O  O   . GLU A 1 432 ? 9.913   -33.898 -24.513 1.00 38.52  ? 695  GLU A O   1 
ATOM   3117 C  CB  . GLU A 1 432 ? 12.081  -34.870 -22.455 1.00 49.38  ? 695  GLU A CB  1 
ATOM   3118 C  CG  . GLU A 1 432 ? 12.711  -36.203 -22.807 1.00 68.09  ? 695  GLU A CG  1 
ATOM   3119 C  CD  . GLU A 1 432 ? 14.186  -36.173 -23.176 1.00 80.99  ? 695  GLU A CD  1 
ATOM   3120 O  OE1 . GLU A 1 432 ? 14.622  -37.077 -23.914 1.00 74.46  ? 695  GLU A OE1 1 
ATOM   3121 O  OE2 . GLU A 1 432 ? 14.896  -35.250 -22.726 1.00 80.95  ? 695  GLU A OE2 1 
ATOM   3122 N  N   . PRO A 1 433 ? 11.541  -34.735 -25.829 1.00 39.74  ? 696  PRO A N   1 
ATOM   3123 C  CA  . PRO A 1 433 ? 10.631  -35.018 -26.925 1.00 38.51  ? 696  PRO A CA  1 
ATOM   3124 C  C   . PRO A 1 433 ? 9.589   -36.087 -26.577 1.00 36.64  ? 696  PRO A C   1 
ATOM   3125 O  O   . PRO A 1 433 ? 9.905   -36.992 -25.858 1.00 32.10  ? 696  PRO A O   1 
ATOM   3126 C  CB  . PRO A 1 433 ? 11.552  -35.530 -28.038 1.00 43.79  ? 696  PRO A CB  1 
ATOM   3127 C  CG  . PRO A 1 433 ? 12.930  -35.053 -27.638 1.00 47.33  ? 696  PRO A CG  1 
ATOM   3128 C  CD  . PRO A 1 433 ? 12.922  -35.091 -26.127 1.00 38.21  ? 696  PRO A CD  1 
ATOM   3129 N  N   . SER A 1 434 ? 8.372   -35.922 -27.092 1.00 31.70  ? 697  SER A N   1 
ATOM   3130 C  CA  . SER A 1 434 ? 7.300   -36.919 -26.874 1.00 32.30  ? 697  SER A CA  1 
ATOM   3131 C  C   . SER A 1 434 ? 7.730   -38.304 -27.378 1.00 31.42  ? 697  SER A C   1 
ATOM   3132 O  O   . SER A 1 434 ? 8.319   -38.382 -28.393 1.00 36.39  ? 697  SER A O   1 
ATOM   3133 C  CB  . SER A 1 434 ? 6.059   -36.436 -27.605 1.00 28.45  ? 697  SER A CB  1 
ATOM   3134 O  OG  . SER A 1 434 ? 5.505   -35.312 -26.958 1.00 29.86  ? 697  SER A OG  1 
ATOM   3135 N  N   . ARG A 1 435 ? 7.423   -39.351 -26.603 0.50 33.83  ? 698  ARG A N   1 
ATOM   3136 C  CA  . ARG A 1 435 ? 7.414   -40.776 -27.030 0.50 37.82  ? 698  ARG A CA  1 
ATOM   3137 C  C   . ARG A 1 435 ? 6.145   -41.034 -27.852 0.50 37.17  ? 698  ARG A C   1 
ATOM   3138 O  O   . ARG A 1 435 ? 5.056   -40.825 -27.301 0.50 39.80  ? 698  ARG A O   1 
ATOM   3139 C  CB  . ARG A 1 435 ? 7.361   -41.717 -25.818 0.50 40.34  ? 698  ARG A CB  1 
ATOM   3140 C  CG  . ARG A 1 435 ? 8.571   -41.648 -24.897 0.50 45.45  ? 698  ARG A CG  1 
ATOM   3141 C  CD  . ARG A 1 435 ? 8.437   -42.574 -23.701 0.50 47.60  ? 698  ARG A CD  1 
ATOM   3142 N  NE  . ARG A 1 435 ? 8.025   -41.855 -22.502 0.50 51.04  ? 698  ARG A NE  1 
ATOM   3143 C  CZ  . ARG A 1 435 ? 8.784   -41.688 -21.422 0.50 54.14  ? 698  ARG A CZ  1 
ATOM   3144 N  NH1 . ARG A 1 435 ? 10.000  -42.206 -21.377 0.50 55.17  ? 698  ARG A NH1 1 
ATOM   3145 N  NH2 . ARG A 1 435 ? 8.320   -41.019 -20.384 0.50 55.25  ? 698  ARG A NH2 1 
ATOM   3146 N  N   . GLY A 1 436 ? 6.268   -41.507 -29.089 1.00 34.51  ? 699  GLY A N   1 
ATOM   3147 C  CA  . GLY A 1 436 ? 5.108   -41.864 -29.907 1.00 38.06  ? 699  GLY A CA  1 
ATOM   3148 C  C   . GLY A 1 436 ? 4.851   -43.364 -29.873 1.00 37.37  ? 699  GLY A C   1 
ATOM   3149 O  O   . GLY A 1 436 ? 5.665   -44.079 -29.362 1.00 33.33  ? 699  GLY A O   1 
ATOM   3150 N  N   . TRP A 1 437 ? 3.730   -43.807 -30.414 1.00 30.39  ? 700  TRP A N   1 
ATOM   3151 C  CA  . TRP A 1 437 ? 3.352   -45.227 -30.465 1.00 30.13  ? 700  TRP A CA  1 
ATOM   3152 C  C   . TRP A 1 437 ? 3.466   -45.642 -31.925 1.00 32.85  ? 700  TRP A C   1 
ATOM   3153 O  O   . TRP A 1 437 ? 2.983   -44.879 -32.784 1.00 31.65  ? 700  TRP A O   1 
ATOM   3154 C  CB  . TRP A 1 437 ? 1.939   -45.374 -29.903 1.00 28.91  ? 700  TRP A CB  1 
ATOM   3155 C  CG  . TRP A 1 437 ? 1.784   -44.937 -28.489 1.00 27.57  ? 700  TRP A CG  1 
ATOM   3156 C  CD1 . TRP A 1 437 ? 1.487   -43.687 -28.038 1.00 31.42  ? 700  TRP A CD1 1 
ATOM   3157 C  CD2 . TRP A 1 437 ? 1.949   -45.763 -27.329 1.00 28.27  ? 700  TRP A CD2 1 
ATOM   3158 N  NE1 . TRP A 1 437 ? 1.440   -43.685 -26.675 1.00 32.65  ? 700  TRP A NE1 1 
ATOM   3159 C  CE2 . TRP A 1 437 ? 1.692   -44.948 -26.217 1.00 29.56  ? 700  TRP A CE2 1 
ATOM   3160 C  CE3 . TRP A 1 437 ? 2.260   -47.101 -27.160 1.00 28.71  ? 700  TRP A CE3 1 
ATOM   3161 C  CZ2 . TRP A 1 437 ? 1.733   -45.425 -24.918 1.00 30.40  ? 700  TRP A CZ2 1 
ATOM   3162 C  CZ3 . TRP A 1 437 ? 2.300   -47.577 -25.878 1.00 34.66  ? 700  TRP A CZ3 1 
ATOM   3163 C  CH2 . TRP A 1 437 ? 2.026   -46.758 -24.781 1.00 31.74  ? 700  TRP A CH2 1 
ATOM   3164 N  N   . ASN A 1 438 ? 4.083   -46.787 -32.193 1.00 27.66  ? 701  ASN A N   1 
ATOM   3165 C  CA  . ASN A 1 438 ? 4.179   -47.331 -33.557 1.00 32.50  ? 701  ASN A CA  1 
ATOM   3166 C  C   . ASN A 1 438 ? 2.985   -48.167 -33.935 1.00 33.93  ? 701  ASN A C   1 
ATOM   3167 O  O   . ASN A 1 438 ? 2.880   -48.456 -35.141 1.00 40.14  ? 701  ASN A O   1 
ATOM   3168 C  CB  . ASN A 1 438 ? 5.456   -48.179 -33.717 1.00 39.46  ? 701  ASN A CB  1 
ATOM   3169 C  CG  . ASN A 1 438 ? 6.669   -47.301 -33.463 1.00 48.63  ? 701  ASN A CG  1 
ATOM   3170 O  OD1 . ASN A 1 438 ? 7.492   -47.599 -32.594 1.00 53.12  ? 701  ASN A OD1 1 
ATOM   3171 N  ND2 . ASN A 1 438 ? 6.692   -46.154 -34.132 1.00 41.00  ? 701  ASN A ND2 1 
ATOM   3172 N  N   . ASP A 1 439 ? 2.112   -48.558 -33.009 1.00 35.88  ? 702  ASP A N   1 
ATOM   3173 C  CA  . ASP A 1 439 ? 0.995   -49.473 -33.401 1.00 36.84  ? 702  ASP A CA  1 
ATOM   3174 C  C   . ASP A 1 439 ? -0.288  -48.940 -32.772 1.00 32.13  ? 702  ASP A C   1 
ATOM   3175 O  O   . ASP A 1 439 ? -0.317  -48.796 -31.525 1.00 31.68  ? 702  ASP A O   1 
ATOM   3176 C  CB  . ASP A 1 439 ? 1.463   -50.894 -33.048 1.00 40.99  ? 702  ASP A CB  1 
ATOM   3177 C  CG  . ASP A 1 439 ? 0.420   -51.986 -32.907 1.00 48.88  ? 702  ASP A CG  1 
ATOM   3178 O  OD1 . ASP A 1 439 ? -0.743  -51.803 -33.425 1.00 46.29  ? 702  ASP A OD1 1 
ATOM   3179 O  OD2 . ASP A 1 439 ? 0.794   -53.034 -32.251 1.00 57.33  ? 702  ASP A OD2 1 
ATOM   3180 N  N   . TRP A 1 440 ? -1.319  -48.718 -33.583 1.00 29.46  ? 703  TRP A N   1 
ATOM   3181 C  CA  . TRP A 1 440 ? -2.601  -48.147 -33.114 1.00 29.92  ? 703  TRP A CA  1 
ATOM   3182 C  C   . TRP A 1 440 ? -3.225  -49.011 -32.013 1.00 27.71  ? 703  TRP A C   1 
ATOM   3183 O  O   . TRP A 1 440 ? -3.972  -48.466 -31.137 1.00 26.38  ? 703  TRP A O   1 
ATOM   3184 C  CB  . TRP A 1 440 ? -3.536  -47.917 -34.297 1.00 29.97  ? 703  TRP A CB  1 
ATOM   3185 C  CG  . TRP A 1 440 ? -4.058  -49.161 -34.951 1.00 31.35  ? 703  TRP A CG  1 
ATOM   3186 C  CD1 . TRP A 1 440 ? -3.526  -49.811 -36.028 1.00 37.40  ? 703  TRP A CD1 1 
ATOM   3187 C  CD2 . TRP A 1 440 ? -5.195  -49.925 -34.566 1.00 32.09  ? 703  TRP A CD2 1 
ATOM   3188 N  NE1 . TRP A 1 440 ? -4.300  -50.875 -36.390 1.00 32.77  ? 703  TRP A NE1 1 
ATOM   3189 C  CE2 . TRP A 1 440 ? -5.309  -50.998 -35.488 1.00 34.45  ? 703  TRP A CE2 1 
ATOM   3190 C  CE3 . TRP A 1 440 ? -6.153  -49.780 -33.567 1.00 30.21  ? 703  TRP A CE3 1 
ATOM   3191 C  CZ2 . TRP A 1 440 ? -6.320  -51.953 -35.415 1.00 30.91  ? 703  TRP A CZ2 1 
ATOM   3192 C  CZ3 . TRP A 1 440 ? -7.175  -50.706 -33.519 1.00 30.68  ? 703  TRP A CZ3 1 
ATOM   3193 C  CH2 . TRP A 1 440 ? -7.235  -51.785 -34.407 1.00 34.39  ? 703  TRP A CH2 1 
ATOM   3194 N  N   . THR A 1 441 ? -2.888  -50.288 -31.966 1.00 25.75  ? 704  THR A N   1 
ATOM   3195 C  CA  . THR A 1 441 ? -3.418  -51.215 -30.938 1.00 26.90  ? 704  THR A CA  1 
ATOM   3196 C  C   . THR A 1 441 ? -2.783  -50.993 -29.569 1.00 27.53  ? 704  THR A C   1 
ATOM   3197 O  O   . THR A 1 441 ? -3.277  -51.586 -28.588 1.00 28.61  ? 704  THR A O   1 
ATOM   3198 C  CB  . THR A 1 441 ? -3.359  -52.688 -31.367 1.00 27.51  ? 704  THR A CB  1 
ATOM   3199 O  OG1 . THR A 1 441 ? -2.007  -53.129 -31.475 1.00 27.13  ? 704  THR A OG1 1 
ATOM   3200 C  CG2 . THR A 1 441 ? -4.048  -52.934 -32.685 1.00 27.70  ? 704  THR A CG2 1 
ATOM   3201 N  N   . GLN A 1 442 ? -1.736  -50.164 -29.478 0.50 27.04  ? 705  GLN A N   1 
ATOM   3202 C  CA  . GLN A 1 442 ? -1.041  -49.876 -28.196 0.50 26.51  ? 705  GLN A CA  1 
ATOM   3203 C  C   . GLN A 1 442 ? -1.328  -48.444 -27.736 0.50 24.49  ? 705  GLN A C   1 
ATOM   3204 O  O   . GLN A 1 442 ? -0.846  -48.084 -26.658 0.50 23.26  ? 705  GLN A O   1 
ATOM   3205 C  CB  . GLN A 1 442 ? 0.459   -50.142 -28.338 0.50 29.09  ? 705  GLN A CB  1 
ATOM   3206 C  CG  . GLN A 1 442 ? 0.754   -51.436 -29.087 0.50 30.85  ? 705  GLN A CG  1 
ATOM   3207 C  CD  . GLN A 1 442 ? 0.357   -52.647 -28.285 0.50 31.73  ? 705  GLN A CD  1 
ATOM   3208 O  OE1 . GLN A 1 442 ? 0.733   -52.767 -27.125 0.50 31.25  ? 705  GLN A OE1 1 
ATOM   3209 N  NE2 . GLN A 1 442 ? -0.390  -53.563 -28.899 0.50 34.31  ? 705  GLN A NE2 1 
ATOM   3210 N  N   . VAL A 1 443 ? -2.050  -47.653 -28.526 1.00 23.86  ? 706  VAL A N   1 
ATOM   3211 C  CA  . VAL A 1 443 ? -2.319  -46.209 -28.195 1.00 26.68  ? 706  VAL A CA  1 
ATOM   3212 C  C   . VAL A 1 443 ? -3.354  -46.148 -27.087 1.00 22.91  ? 706  VAL A C   1 
ATOM   3213 O  O   . VAL A 1 443 ? -4.379  -46.785 -27.192 1.00 24.84  ? 706  VAL A O   1 
ATOM   3214 C  CB  . VAL A 1 443 ? -2.794  -45.414 -29.430 1.00 31.05  ? 706  VAL A CB  1 
ATOM   3215 C  CG1 . VAL A 1 443 ? -3.257  -43.998 -29.110 1.00 34.72  ? 706  VAL A CG1 1 
ATOM   3216 C  CG2 . VAL A 1 443 ? -1.660  -45.328 -30.409 1.00 33.93  ? 706  VAL A CG2 1 
ATOM   3217 N  N   . PRO A 1 444 ? -3.139  -45.395 -25.992 1.00 21.87  ? 707  PRO A N   1 
ATOM   3218 C  CA  . PRO A 1 444 ? -4.200  -45.198 -25.023 1.00 22.99  ? 707  PRO A CA  1 
ATOM   3219 C  C   . PRO A 1 444 ? -5.182  -44.108 -25.486 1.00 25.30  ? 707  PRO A C   1 
ATOM   3220 O  O   . PRO A 1 444 ? -4.724  -43.092 -25.999 1.00 22.31  ? 707  PRO A O   1 
ATOM   3221 C  CB  . PRO A 1 444 ? -3.438  -44.731 -23.775 1.00 26.60  ? 707  PRO A CB  1 
ATOM   3222 C  CG  . PRO A 1 444 ? -2.175  -44.038 -24.316 1.00 25.05  ? 707  PRO A CG  1 
ATOM   3223 C  CD  . PRO A 1 444 ? -1.887  -44.683 -25.656 1.00 23.61  ? 707  PRO A CD  1 
ATOM   3224 N  N   . PHE A 1 445 ? -6.487  -44.277 -25.256 1.00 22.84  ? 708  PHE A N   1 
ATOM   3225 C  CA  . PHE A 1 445 ? -7.485  -43.220 -25.594 1.00 22.79  ? 708  PHE A CA  1 
ATOM   3226 C  C   . PHE A 1 445 ? -8.743  -43.482 -24.788 1.00 22.70  ? 708  PHE A C   1 
ATOM   3227 O  O   . PHE A 1 445 ? -9.219  -44.655 -24.829 1.00 19.13  ? 708  PHE A O   1 
ATOM   3228 C  CB  . PHE A 1 445 ? -7.831  -43.228 -27.095 1.00 21.26  ? 708  PHE A CB  1 
ATOM   3229 C  CG  . PHE A 1 445 ? -8.679  -42.068 -27.606 1.00 23.43  ? 708  PHE A CG  1 
ATOM   3230 C  CD1 . PHE A 1 445 ? -8.408  -40.759 -27.245 1.00 24.50  ? 708  PHE A CD1 1 
ATOM   3231 C  CD2 . PHE A 1 445 ? -9.797  -42.303 -28.374 1.00 25.87  ? 708  PHE A CD2 1 
ATOM   3232 C  CE1 . PHE A 1 445 ? -9.156  -39.695 -27.745 1.00 25.55  ? 708  PHE A CE1 1 
ATOM   3233 C  CE2 . PHE A 1 445 ? -10.532 -41.246 -28.911 1.00 29.09  ? 708  PHE A CE2 1 
ATOM   3234 C  CZ  . PHE A 1 445 ? -10.247 -39.943 -28.529 1.00 26.06  ? 708  PHE A CZ  1 
ATOM   3235 N  N   . CYS A 1 446 ? -9.268  -42.454 -24.115 1.00 23.26  ? 709  CYS A N   1 
ATOM   3236 C  CA  . CYS A 1 446 ? -10.524 -42.543 -23.282 1.00 25.49  ? 709  CYS A CA  1 
ATOM   3237 C  C   . CYS A 1 446 ? -10.440 -43.737 -22.305 1.00 24.20  ? 709  CYS A C   1 
ATOM   3238 O  O   . CYS A 1 446 ? -11.419 -44.537 -22.240 1.00 24.93  ? 709  CYS A O   1 
ATOM   3239 C  CB  . CYS A 1 446 ? -11.703 -42.648 -24.234 1.00 28.03  ? 709  CYS A CB  1 
ATOM   3240 S  SG  . CYS A 1 446 ? -11.916 -41.098 -25.175 1.00 30.55  ? 709  CYS A SG  1 
ATOM   3241 N  N   . SER A 1 447 ? -9.267  -43.914 -21.685 1.00 23.04  ? 710  SER A N   1 
ATOM   3242 C  CA  . SER A 1 447 ? -8.978  -44.911 -20.623 1.00 27.62  ? 710  SER A CA  1 
ATOM   3243 C  C   . SER A 1 447 ? -8.931  -46.338 -21.203 1.00 26.51  ? 710  SER A C   1 
ATOM   3244 O  O   . SER A 1 447 ? -8.852  -47.299 -20.410 1.00 29.12  ? 710  SER A O   1 
ATOM   3245 C  CB  . SER A 1 447 ? -10.043 -44.847 -19.533 1.00 30.77  ? 710  SER A CB  1 
ATOM   3246 O  OG  . SER A 1 447 ? -10.074 -43.574 -18.925 1.00 34.93  ? 710  SER A OG  1 
ATOM   3247 N  N   . HIS A 1 448 ? -8.885  -46.507 -22.523 1.00 23.66  ? 711  HIS A N   1 
ATOM   3248 C  CA  . HIS A 1 448 ? -8.864  -47.848 -23.166 1.00 21.54  ? 711  HIS A CA  1 
ATOM   3249 C  C   . HIS A 1 448 ? -7.645  -48.024 -24.086 1.00 20.45  ? 711  HIS A C   1 
ATOM   3250 O  O   . HIS A 1 448 ? -6.981  -47.035 -24.437 1.00 20.92  ? 711  HIS A O   1 
ATOM   3251 C  CB  . HIS A 1 448 ? -10.145 -48.076 -23.976 1.00 20.26  ? 711  HIS A CB  1 
ATOM   3252 C  CG  . HIS A 1 448 ? -11.353 -48.257 -23.118 1.00 21.47  ? 711  HIS A CG  1 
ATOM   3253 N  ND1 . HIS A 1 448 ? -11.950 -47.184 -22.472 1.00 20.36  ? 711  HIS A ND1 1 
ATOM   3254 C  CD2 . HIS A 1 448 ? -12.055 -49.374 -22.788 1.00 21.65  ? 711  HIS A CD2 1 
ATOM   3255 C  CE1 . HIS A 1 448 ? -12.982 -47.647 -21.748 1.00 24.72  ? 711  HIS A CE1 1 
ATOM   3256 N  NE2 . HIS A 1 448 ? -13.076 -49.002 -21.925 1.00 20.68  ? 711  HIS A NE2 1 
ATOM   3257 N  N   . HIS A 1 449 ? -7.441  -49.267 -24.516 1.00 19.07  ? 712  HIS A N   1 
ATOM   3258 C  CA  . HIS A 1 449 ? -6.723  -49.607 -25.774 1.00 21.09  ? 712  HIS A CA  1 
ATOM   3259 C  C   . HIS A 1 449 ? -7.659  -50.497 -26.560 1.00 20.40  ? 712  HIS A C   1 
ATOM   3260 O  O   . HIS A 1 449 ? -8.731  -50.818 -26.036 1.00 23.11  ? 712  HIS A O   1 
ATOM   3261 C  CB  . HIS A 1 449 ? -5.416  -50.374 -25.549 1.00 20.88  ? 712  HIS A CB  1 
ATOM   3262 C  CG  . HIS A 1 449 ? -5.583  -51.571 -24.673 1.00 21.21  ? 712  HIS A CG  1 
ATOM   3263 N  ND1 . HIS A 1 449 ? -5.733  -51.430 -23.329 1.00 21.50  ? 712  HIS A ND1 1 
ATOM   3264 C  CD2 . HIS A 1 449 ? -5.679  -52.892 -24.931 1.00 21.25  ? 712  HIS A CD2 1 
ATOM   3265 C  CE1 . HIS A 1 449 ? -5.902  -52.629 -22.786 1.00 22.45  ? 712  HIS A CE1 1 
ATOM   3266 N  NE2 . HIS A 1 449 ? -5.880  -53.526 -23.738 1.00 21.21  ? 712  HIS A NE2 1 
ATOM   3267 N  N   . PHE A 1 450 ? -7.273  -50.821 -27.780 1.00 21.21  ? 713  PHE A N   1 
ATOM   3268 C  CA  . PHE A 1 450 ? -8.139  -51.460 -28.782 1.00 21.88  ? 713  PHE A CA  1 
ATOM   3269 C  C   . PHE A 1 450 ? -7.430  -52.638 -29.428 1.00 24.32  ? 713  PHE A C   1 
ATOM   3270 O  O   . PHE A 1 450 ? -6.238  -52.532 -29.779 1.00 24.73  ? 713  PHE A O   1 
ATOM   3271 C  CB  . PHE A 1 450 ? -8.609  -50.399 -29.774 1.00 24.39  ? 713  PHE A CB  1 
ATOM   3272 C  CG  . PHE A 1 450 ? -9.349  -49.289 -29.071 1.00 22.43  ? 713  PHE A CG  1 
ATOM   3273 C  CD1 . PHE A 1 450 ? -8.664  -48.228 -28.519 1.00 24.82  ? 713  PHE A CD1 1 
ATOM   3274 C  CD2 . PHE A 1 450 ? -10.705 -49.373 -28.862 1.00 25.83  ? 713  PHE A CD2 1 
ATOM   3275 C  CE1 . PHE A 1 450 ? -9.345  -47.244 -27.811 1.00 25.46  ? 713  PHE A CE1 1 
ATOM   3276 C  CE2 . PHE A 1 450 ? -11.382 -48.395 -28.162 1.00 25.30  ? 713  PHE A CE2 1 
ATOM   3277 C  CZ  . PHE A 1 450 ? -10.697 -47.325 -27.651 1.00 25.62  ? 713  PHE A CZ  1 
ATOM   3278 N  N   . HIS A 1 451 ? -8.145  -53.759 -29.527 1.00 25.14  ? 714  HIS A N   1 
ATOM   3279 C  CA  . HIS A 1 451 ? -7.648  -55.000 -30.149 1.00 24.01  ? 714  HIS A CA  1 
ATOM   3280 C  C   . HIS A 1 451 ? -8.320  -55.210 -31.495 1.00 25.15  ? 714  HIS A C   1 
ATOM   3281 O  O   . HIS A 1 451 ? -9.555  -54.911 -31.662 1.00 25.85  ? 714  HIS A O   1 
ATOM   3282 C  CB  . HIS A 1 451 ? -7.900  -56.185 -29.187 1.00 23.03  ? 714  HIS A CB  1 
ATOM   3283 C  CG  . HIS A 1 451 ? -7.155  -56.165 -27.877 1.00 22.53  ? 714  HIS A CG  1 
ATOM   3284 N  ND1 . HIS A 1 451 ? -6.045  -56.910 -27.666 1.00 24.61  ? 714  HIS A ND1 1 
ATOM   3285 C  CD2 . HIS A 1 451 ? -7.450  -55.606 -26.673 1.00 23.99  ? 714  HIS A CD2 1 
ATOM   3286 C  CE1 . HIS A 1 451 ? -5.663  -56.798 -26.387 1.00 23.64  ? 714  HIS A CE1 1 
ATOM   3287 N  NE2 . HIS A 1 451 ? -6.505  -55.969 -25.752 1.00 16.88  ? 714  HIS A NE2 1 
ATOM   3288 N  N   . GLU A 1 452 ? -7.588  -55.806 -32.432 1.00 27.20  ? 715  GLU A N   1 
ATOM   3289 C  CA  . GLU A 1 452 ? -8.133  -56.339 -33.718 1.00 27.46  ? 715  GLU A CA  1 
ATOM   3290 C  C   . GLU A 1 452 ? -8.465  -57.834 -33.519 1.00 29.63  ? 715  GLU A C   1 
ATOM   3291 O  O   . GLU A 1 452 ? -7.642  -58.566 -33.017 1.00 32.07  ? 715  GLU A O   1 
ATOM   3292 C  CB  . GLU A 1 452 ? -7.129  -56.115 -34.855 1.00 32.99  ? 715  GLU A CB  1 
ATOM   3293 C  CG  . GLU A 1 452 ? -7.842  -55.694 -36.139 1.00 42.07  ? 715  GLU A CG  1 
ATOM   3294 C  CD  . GLU A 1 452 ? -6.962  -55.317 -37.336 1.00 51.37  ? 715  GLU A CD  1 
ATOM   3295 O  OE1 . GLU A 1 452 ? -7.446  -54.541 -38.221 1.00 44.11  ? 715  GLU A OE1 1 
ATOM   3296 O  OE2 . GLU A 1 452 ? -5.811  -55.812 -37.394 1.00 61.59  ? 715  GLU A OE2 1 
ATOM   3297 N  N   . LEU A 1 453 ? -9.704  -58.245 -33.690 1.00 25.03  ? 716  LEU A N   1 
ATOM   3298 C  CA  . LEU A 1 453 ? -10.154 -59.593 -33.281 1.00 30.07  ? 716  LEU A CA  1 
ATOM   3299 C  C   . LEU A 1 453 ? -10.872 -60.219 -34.468 1.00 33.42  ? 716  LEU A C   1 
ATOM   3300 O  O   . LEU A 1 453 ? -11.790 -59.577 -35.023 1.00 33.47  ? 716  LEU A O   1 
ATOM   3301 C  CB  . LEU A 1 453 ? -11.030 -59.382 -32.037 1.00 33.14  ? 716  LEU A CB  1 
ATOM   3302 C  CG  . LEU A 1 453 ? -11.870 -60.558 -31.587 1.00 41.14  ? 716  LEU A CG  1 
ATOM   3303 C  CD1 . LEU A 1 453 ? -10.987 -61.749 -31.329 1.00 45.62  ? 716  LEU A CD1 1 
ATOM   3304 C  CD2 . LEU A 1 453 ? -12.677 -60.185 -30.337 1.00 40.65  ? 716  LEU A CD2 1 
ATOM   3305 N  N   . ILE A 1 454 ? -10.356 -61.347 -34.944 1.00 35.21  ? 717  ILE A N   1 
ATOM   3306 C  CA  . ILE A 1 454 ? -10.863 -61.952 -36.202 1.00 35.27  ? 717  ILE A CA  1 
ATOM   3307 C  C   . ILE A 1 454 ? -11.851 -63.056 -35.839 1.00 33.04  ? 717  ILE A C   1 
ATOM   3308 O  O   . ILE A 1 454 ? -11.561 -63.907 -34.984 1.00 34.10  ? 717  ILE A O   1 
ATOM   3309 C  CB  . ILE A 1 454 ? -9.699  -62.395 -37.113 1.00 47.95  ? 717  ILE A CB  1 
ATOM   3310 C  CG1 . ILE A 1 454 ? -8.891  -61.179 -37.594 1.00 47.24  ? 717  ILE A CG1 1 
ATOM   3311 C  CG2 . ILE A 1 454 ? -10.193 -63.184 -38.326 1.00 50.15  ? 717  ILE A CG2 1 
ATOM   3312 C  CD1 . ILE A 1 454 ? -7.521  -61.561 -38.033 1.00 55.02  ? 717  ILE A CD1 1 
ATOM   3313 N  N   . MET A 1 455 ? -13.045 -62.915 -36.361 1.00 32.20  ? 718  MET A N   1 
ATOM   3314 C  CA  . MET A 1 455 ? -14.134 -63.888 -36.133 1.00 34.43  ? 718  MET A CA  1 
ATOM   3315 C  C   . MET A 1 455 ? -13.830 -65.157 -36.927 1.00 38.47  ? 718  MET A C   1 
ATOM   3316 O  O   . MET A 1 455 ? -13.203 -65.073 -38.012 1.00 33.41  ? 718  MET A O   1 
ATOM   3317 C  CB  . MET A 1 455 ? -15.467 -63.329 -36.606 1.00 34.16  ? 718  MET A CB  1 
ATOM   3318 C  CG  . MET A 1 455 ? -15.917 -62.216 -35.749 1.00 34.97  ? 718  MET A CG  1 
ATOM   3319 S  SD  . MET A 1 455 ? -17.422 -61.417 -36.267 1.00 37.21  ? 718  MET A SD  1 
ATOM   3320 C  CE  . MET A 1 455 ? -18.637 -62.658 -35.834 1.00 37.91  ? 718  MET A CE  1 
ATOM   3321 N  N   A LYS A 1 456 ? -14.280 -66.303 -36.415 0.25 39.03  ? 719  LYS A N   1 
ATOM   3322 N  N   B LYS A 1 456 ? -14.285 -66.300 -36.409 0.25 38.96  ? 719  LYS A N   1 
ATOM   3323 C  CA  A LYS A 1 456 ? -14.104 -67.632 -37.064 0.25 41.83  ? 719  LYS A CA  1 
ATOM   3324 C  CA  B LYS A 1 456 ? -14.136 -67.635 -37.052 0.25 41.73  ? 719  LYS A CA  1 
ATOM   3325 C  C   A LYS A 1 456 ? -14.509 -67.540 -38.544 0.25 41.27  ? 719  LYS A C   1 
ATOM   3326 C  C   B LYS A 1 456 ? -14.499 -67.527 -38.541 0.25 41.13  ? 719  LYS A C   1 
ATOM   3327 O  O   A LYS A 1 456 ? -13.887 -68.242 -39.359 0.25 43.11  ? 719  LYS A O   1 
ATOM   3328 O  O   B LYS A 1 456 ? -13.844 -68.202 -39.354 0.25 42.55  ? 719  LYS A O   1 
ATOM   3329 C  CB  A LYS A 1 456 ? -14.876 -68.705 -36.288 0.25 43.68  ? 719  LYS A CB  1 
ATOM   3330 C  CB  B LYS A 1 456 ? -14.987 -68.679 -36.320 0.25 43.49  ? 719  LYS A CB  1 
ATOM   3331 C  CG  A LYS A 1 456 ? -14.022 -69.526 -35.329 0.25 45.53  ? 719  LYS A CG  1 
ATOM   3332 C  CG  B LYS A 1 456 ? -14.957 -70.069 -36.940 0.25 46.32  ? 719  LYS A CG  1 
ATOM   3333 C  CD  A LYS A 1 456 ? -14.813 -70.251 -34.262 0.25 48.18  ? 719  LYS A CD  1 
ATOM   3334 C  CD  B LYS A 1 456 ? -14.819 -71.201 -35.940 0.25 45.48  ? 719  LYS A CD  1 
ATOM   3335 C  CE  A LYS A 1 456 ? -15.301 -69.332 -33.161 0.25 46.70  ? 719  LYS A CE  1 
ATOM   3336 C  CE  B LYS A 1 456 ? -15.151 -72.550 -36.545 0.25 44.86  ? 719  LYS A CE  1 
ATOM   3337 N  NZ  A LYS A 1 456 ? -16.541 -69.851 -32.539 0.25 45.76  ? 719  LYS A NZ  1 
ATOM   3338 N  NZ  B LYS A 1 456 ? -14.484 -73.652 -35.814 0.25 46.08  ? 719  LYS A NZ  1 
ATOM   3339 N  N   . ASP A 1 457 ? -15.462 -66.668 -38.888 1.00 40.17  ? 720  ASP A N   1 
ATOM   3340 C  CA  . ASP A 1 457 ? -15.908 -66.475 -40.297 1.00 38.01  ? 720  ASP A CA  1 
ATOM   3341 C  C   . ASP A 1 457 ? -15.107 -65.422 -41.064 1.00 49.43  ? 720  ASP A C   1 
ATOM   3342 O  O   . ASP A 1 457 ? -15.564 -65.049 -42.168 1.00 42.48  ? 720  ASP A O   1 
ATOM   3343 C  CB  . ASP A 1 457 ? -17.399 -66.121 -40.322 1.00 44.84  ? 720  ASP A CB  1 
ATOM   3344 C  CG  . ASP A 1 457 ? -17.781 -64.751 -39.775 1.00 45.79  ? 720  ASP A CG  1 
ATOM   3345 O  OD1 . ASP A 1 457 ? -16.950 -63.811 -39.851 1.00 39.80  ? 720  ASP A OD1 1 
ATOM   3346 O  OD2 . ASP A 1 457 ? -18.941 -64.613 -39.354 1.00 43.23  ? 720  ASP A OD2 1 
ATOM   3347 N  N   . GLY A 1 458 ? -14.003 -64.902 -40.507 1.00 50.20  ? 721  GLY A N   1 
ATOM   3348 C  CA  . GLY A 1 458 ? -13.100 -63.995 -41.237 1.00 40.96  ? 721  GLY A CA  1 
ATOM   3349 C  C   . GLY A 1 458 ? -13.411 -62.521 -41.021 1.00 42.22  ? 721  GLY A C   1 
ATOM   3350 O  O   . GLY A 1 458 ? -12.550 -61.705 -41.339 1.00 47.54  ? 721  GLY A O   1 
ATOM   3351 N  N   . ARG A 1 459 ? -14.589 -62.141 -40.521 1.00 35.94  ? 722  ARG A N   1 
ATOM   3352 C  CA  . ARG A 1 459 ? -14.900 -60.703 -40.388 1.00 32.34  ? 722  ARG A CA  1 
ATOM   3353 C  C   . ARG A 1 459 ? -14.061 -60.151 -39.209 1.00 34.19  ? 722  ARG A C   1 
ATOM   3354 O  O   . ARG A 1 459 ? -13.671 -60.918 -38.270 1.00 37.00  ? 722  ARG A O   1 
ATOM   3355 C  CB  . ARG A 1 459 ? -16.400 -60.499 -40.227 1.00 37.99  ? 722  ARG A CB  1 
ATOM   3356 C  CG  . ARG A 1 459 ? -17.250 -60.956 -41.415 1.00 37.86  ? 722  ARG A CG  1 
ATOM   3357 C  CD  . ARG A 1 459 ? -18.711 -60.584 -41.248 1.00 39.90  ? 722  ARG A CD  1 
ATOM   3358 N  NE  . ARG A 1 459 ? -19.334 -61.491 -40.317 1.00 37.31  ? 722  ARG A NE  1 
ATOM   3359 C  CZ  . ARG A 1 459 ? -20.610 -61.514 -40.057 1.00 35.18  ? 722  ARG A CZ  1 
ATOM   3360 N  NH1 . ARG A 1 459 ? -21.421 -60.642 -40.621 1.00 39.87  ? 722  ARG A NH1 1 
ATOM   3361 N  NH2 . ARG A 1 459 ? -21.067 -62.419 -39.213 1.00 37.46  ? 722  ARG A NH2 1 
ATOM   3362 N  N   . VAL A 1 460 ? -13.827 -58.858 -39.243 1.00 37.42  ? 723  VAL A N   1 
ATOM   3363 C  CA  . VAL A 1 460 ? -12.906 -58.162 -38.315 1.00 37.59  ? 723  VAL A CA  1 
ATOM   3364 C  C   . VAL A 1 460 ? -13.661 -57.266 -37.348 1.00 32.74  ? 723  VAL A C   1 
ATOM   3365 O  O   . VAL A 1 460 ? -14.348 -56.321 -37.782 1.00 41.79  ? 723  VAL A O   1 
ATOM   3366 C  CB  . VAL A 1 460 ? -11.831 -57.390 -39.080 1.00 39.85  ? 723  VAL A CB  1 
ATOM   3367 C  CG1 . VAL A 1 460 ? -10.949 -56.622 -38.098 1.00 47.27  ? 723  VAL A CG1 1 
ATOM   3368 C  CG2 . VAL A 1 460 ? -11.011 -58.366 -39.893 1.00 43.35  ? 723  VAL A CG2 1 
ATOM   3369 N  N   . LEU A 1 461 ? -13.469 -57.526 -36.042 1.00 27.90  ? 724  LEU A N   1 
ATOM   3370 C  CA  . LEU A 1 461 ? -13.955 -56.636 -34.961 1.00 25.71  ? 724  LEU A CA  1 
ATOM   3371 C  C   . LEU A 1 461 ? -12.763 -55.828 -34.400 1.00 27.94  ? 724  LEU A C   1 
ATOM   3372 O  O   . LEU A 1 461 ? -11.652 -56.378 -34.232 1.00 30.69  ? 724  LEU A O   1 
ATOM   3373 C  CB  . LEU A 1 461 ? -14.586 -57.484 -33.876 1.00 26.58  ? 724  LEU A CB  1 
ATOM   3374 C  CG  . LEU A 1 461 ? -15.730 -58.367 -34.351 1.00 27.13  ? 724  LEU A CG  1 
ATOM   3375 C  CD1 . LEU A 1 461 ? -16.039 -59.346 -33.271 1.00 31.37  ? 724  LEU A CD1 1 
ATOM   3376 C  CD2 . LEU A 1 461 ? -16.940 -57.544 -34.722 1.00 27.91  ? 724  LEU A CD2 1 
ATOM   3377 N  N   . VAL A 1 462 ? -12.965 -54.546 -34.188 1.00 24.96  ? 725  VAL A N   1 
ATOM   3378 C  CA  . VAL A 1 462 ? -12.037 -53.720 -33.394 1.00 23.81  ? 725  VAL A CA  1 
ATOM   3379 C  C   . VAL A 1 462 ? -12.730 -53.395 -32.090 1.00 22.15  ? 725  VAL A C   1 
ATOM   3380 O  O   . VAL A 1 462 ? -13.763 -52.742 -32.133 1.00 22.31  ? 725  VAL A O   1 
ATOM   3381 C  CB  . VAL A 1 462 ? -11.588 -52.483 -34.156 1.00 24.79  ? 725  VAL A CB  1 
ATOM   3382 C  CG1 . VAL A 1 462 ? -10.685 -51.651 -33.255 1.00 26.10  ? 725  VAL A CG1 1 
ATOM   3383 C  CG2 . VAL A 1 462 ? -10.917 -52.871 -35.458 1.00 24.19  ? 725  VAL A CG2 1 
ATOM   3384 N  N   . VAL A 1 463 ? -12.198 -53.938 -31.000 1.00 21.70  ? 726  VAL A N   1 
ATOM   3385 C  CA  . VAL A 1 463 ? -12.886 -53.990 -29.689 1.00 22.41  ? 726  VAL A CA  1 
ATOM   3386 C  C   . VAL A 1 463 ? -12.139 -53.143 -28.670 1.00 21.19  ? 726  VAL A C   1 
ATOM   3387 O  O   . VAL A 1 463 ? -10.896 -53.107 -28.658 1.00 21.75  ? 726  VAL A O   1 
ATOM   3388 C  CB  . VAL A 1 463 ? -13.065 -55.439 -29.224 1.00 21.45  ? 726  VAL A CB  1 
ATOM   3389 C  CG1 . VAL A 1 463 ? -13.902 -56.212 -30.252 1.00 24.42  ? 726  VAL A CG1 1 
ATOM   3390 C  CG2 . VAL A 1 463 ? -11.728 -56.140 -28.994 1.00 22.44  ? 726  VAL A CG2 1 
ATOM   3391 N  N   . PRO A 1 464 ? -12.908 -52.496 -27.771 1.00 22.27  ? 727  PRO A N   1 
ATOM   3392 C  CA  . PRO A 1 464 ? -12.332 -51.762 -26.622 1.00 20.65  ? 727  PRO A CA  1 
ATOM   3393 C  C   . PRO A 1 464 ? -11.885 -52.645 -25.466 1.00 20.13  ? 727  PRO A C   1 
ATOM   3394 O  O   . PRO A 1 464 ? -12.466 -53.747 -25.241 1.00 20.55  ? 727  PRO A O   1 
ATOM   3395 C  CB  . PRO A 1 464 ? -13.528 -50.919 -26.212 1.00 21.59  ? 727  PRO A CB  1 
ATOM   3396 C  CG  . PRO A 1 464 ? -14.719 -51.859 -26.469 1.00 22.74  ? 727  PRO A CG  1 
ATOM   3397 C  CD  . PRO A 1 464 ? -14.391 -52.449 -27.817 1.00 21.11  ? 727  PRO A CD  1 
ATOM   3398 N  N   . CYS A 1 465 ? -10.852 -52.217 -24.744 1.00 18.99  ? 728  CYS A N   1 
ATOM   3399 C  CA  . CYS A 1 465 ? -10.243 -53.072 -23.693 1.00 19.72  ? 728  CYS A CA  1 
ATOM   3400 C  C   . CYS A 1 465 ? -9.569  -52.219 -22.633 1.00 21.70  ? 728  CYS A C   1 
ATOM   3401 O  O   . CYS A 1 465 ? -9.139  -51.130 -22.943 1.00 20.37  ? 728  CYS A O   1 
ATOM   3402 C  CB  . CYS A 1 465 ? -9.250  -54.089 -24.276 1.00 19.10  ? 728  CYS A CB  1 
ATOM   3403 S  SG  . CYS A 1 465 ? -8.781  -55.432 -23.127 1.00 21.63  ? 728  CYS A SG  1 
ATOM   3404 N  N   . ARG A 1 466 ? -9.574  -52.687 -21.386 1.00 21.99  ? 729  ARG A N   1 
ATOM   3405 C  CA  . ARG A 1 466 ? -8.684  -52.100 -20.371 1.00 23.66  ? 729  ARG A CA  1 
ATOM   3406 C  C   . ARG A 1 466 ? -8.420  -53.145 -19.317 1.00 22.42  ? 729  ARG A C   1 
ATOM   3407 O  O   . ARG A 1 466 ? -9.024  -54.246 -19.381 1.00 20.64  ? 729  ARG A O   1 
ATOM   3408 C  CB  . ARG A 1 466 ? -9.234  -50.859 -19.696 1.00 29.38  ? 729  ARG A CB  1 
ATOM   3409 C  CG  . ARG A 1 466 ? -10.526 -51.056 -18.962 1.00 34.58  ? 729  ARG A CG  1 
ATOM   3410 C  CD  . ARG A 1 466 ? -11.264 -49.713 -18.797 1.00 31.68  ? 729  ARG A CD  1 
ATOM   3411 N  NE  . ARG A 1 466 ? -10.724 -48.922 -17.729 1.00 27.73  ? 729  ARG A NE  1 
ATOM   3412 C  CZ  . ARG A 1 466 ? -11.299 -47.789 -17.293 1.00 31.18  ? 729  ARG A CZ  1 
ATOM   3413 N  NH1 . ARG A 1 466 ? -12.481 -47.381 -17.747 1.00 30.45  ? 729  ARG A NH1 1 
ATOM   3414 N  NH2 . ARG A 1 466 ? -10.691 -47.106 -16.373 1.00 30.97  ? 729  ARG A NH2 1 
ATOM   3415 N  N   . ASN A 1 467 ? -7.481  -52.856 -18.427 1.00 20.68  ? 730  ASN A N   1 
ATOM   3416 C  CA  . ASN A 1 467 ? -7.075  -53.885 -17.428 1.00 24.61  ? 730  ASN A CA  1 
ATOM   3417 C  C   . ASN A 1 467 ? -8.358  -54.384 -16.721 1.00 23.88  ? 730  ASN A C   1 
ATOM   3418 O  O   . ASN A 1 467 ? -9.094  -53.562 -16.234 1.00 21.21  ? 730  ASN A O   1 
ATOM   3419 C  CB  . ASN A 1 467 ? -6.024  -53.329 -16.464 1.00 23.93  ? 730  ASN A CB  1 
ATOM   3420 C  CG  . ASN A 1 467 ? -5.724  -54.385 -15.429 1.00 29.46  ? 730  ASN A CG  1 
ATOM   3421 O  OD1 . ASN A 1 467 ? -6.444  -54.454 -14.459 1.00 26.68  ? 730  ASN A OD1 1 
ATOM   3422 N  ND2 . ASN A 1 467 ? -4.769  -55.281 -15.716 1.00 29.40  ? 730  ASN A ND2 1 
ATOM   3423 N  N   . GLN A 1 468 ? -8.540  -55.691 -16.548 1.00 21.70  ? 731  GLN A N   1 
ATOM   3424 C  CA  . GLN A 1 468 ? -9.844  -56.232 -16.120 1.00 22.23  ? 731  GLN A CA  1 
ATOM   3425 C  C   . GLN A 1 468 ? -10.087 -55.911 -14.643 1.00 23.62  ? 731  GLN A C   1 
ATOM   3426 O  O   . GLN A 1 468 ? -11.265 -55.794 -14.218 1.00 20.93  ? 731  GLN A O   1 
ATOM   3427 C  CB  . GLN A 1 468 ? -9.887  -57.702 -16.467 1.00 25.78  ? 731  GLN A CB  1 
ATOM   3428 C  CG  . GLN A 1 468 ? -11.243 -58.319 -16.258 1.00 25.41  ? 731  GLN A CG  1 
ATOM   3429 C  CD  . GLN A 1 468 ? -11.222 -59.809 -16.442 1.00 24.52  ? 731  GLN A CD  1 
ATOM   3430 O  OE1 . GLN A 1 468 ? -11.507 -60.298 -17.530 1.00 24.30  ? 731  GLN A OE1 1 
ATOM   3431 N  NE2 . GLN A 1 468 ? -10.869 -60.536 -15.404 1.00 21.00  ? 731  GLN A NE2 1 
ATOM   3432 N  N   . ASP A 1 469 ? -9.020  -55.720 -13.874 1.00 23.66  ? 732  ASP A N   1 
ATOM   3433 C  CA  . ASP A 1 469 ? -9.182  -55.335 -12.444 1.00 25.10  ? 732  ASP A CA  1 
ATOM   3434 C  C   . ASP A 1 469 ? -9.942  -54.005 -12.361 1.00 25.34  ? 732  ASP A C   1 
ATOM   3435 O  O   . ASP A 1 469 ? -10.715 -53.805 -11.395 1.00 24.78  ? 732  ASP A O   1 
ATOM   3436 C  CB  . ASP A 1 469 ? -7.837  -55.176 -11.746 1.00 24.85  ? 732  ASP A CB  1 
ATOM   3437 C  CG  . ASP A 1 469 ? -7.118  -56.507 -11.475 1.00 28.49  ? 732  ASP A CG  1 
ATOM   3438 O  OD1 . ASP A 1 469 ? -7.721  -57.566 -11.609 1.00 25.80  ? 732  ASP A OD1 1 
ATOM   3439 O  OD2 . ASP A 1 469 ? -5.917  -56.453 -11.207 1.00 32.85  ? 732  ASP A OD2 1 
ATOM   3440 N  N   . GLU A 1 470 ? -9.665  -53.068 -13.268 1.00 23.38  ? 733  GLU A N   1 
ATOM   3441 C  CA  . GLU A 1 470 ? -10.355 -51.755 -13.264 1.00 24.12  ? 733  GLU A CA  1 
ATOM   3442 C  C   . GLU A 1 470 ? -11.850 -51.990 -13.573 1.00 21.93  ? 733  GLU A C   1 
ATOM   3443 O  O   . GLU A 1 470 ? -12.730 -51.335 -12.938 1.00 22.68  ? 733  GLU A O   1 
ATOM   3444 C  CB  . GLU A 1 470 ? -9.802  -50.845 -14.340 1.00 25.90  ? 733  GLU A CB  1 
ATOM   3445 C  CG  . GLU A 1 470 ? -8.324  -50.559 -14.193 1.00 33.49  ? 733  GLU A CG  1 
ATOM   3446 C  CD  . GLU A 1 470 ? -7.690  -49.794 -15.354 1.00 37.87  ? 733  GLU A CD  1 
ATOM   3447 O  OE1 . GLU A 1 470 ? -6.461  -49.714 -15.347 1.00 45.11  ? 733  GLU A OE1 1 
ATOM   3448 O  OE2 . GLU A 1 470 ? -8.419  -49.256 -16.267 1.00 35.95  ? 733  GLU A OE2 1 
ATOM   3449 N  N   . LEU A 1 471 ? -12.168 -52.874 -14.512 1.00 22.42  ? 734  LEU A N   1 
ATOM   3450 C  CA  . LEU A 1 471 ? -13.573 -53.100 -14.932 1.00 22.24  ? 734  LEU A CA  1 
ATOM   3451 C  C   . LEU A 1 471 ? -14.363 -53.752 -13.774 1.00 21.97  ? 734  LEU A C   1 
ATOM   3452 O  O   . LEU A 1 471 ? -15.487 -53.273 -13.417 1.00 22.34  ? 734  LEU A O   1 
ATOM   3453 C  CB  . LEU A 1 471 ? -13.628 -53.923 -16.202 1.00 23.00  ? 734  LEU A CB  1 
ATOM   3454 C  CG  . LEU A 1 471 ? -13.115 -53.209 -17.456 1.00 24.29  ? 734  LEU A CG  1 
ATOM   3455 C  CD1 . LEU A 1 471 ? -13.048 -54.185 -18.605 1.00 23.59  ? 734  LEU A CD1 1 
ATOM   3456 C  CD2 . LEU A 1 471 ? -14.010 -52.045 -17.817 1.00 26.75  ? 734  LEU A CD2 1 
ATOM   3457 N  N   . ILE A 1 472 ? -13.793 -54.759 -13.126 1.00 22.88  ? 735  ILE A N   1 
ATOM   3458 C  CA  . ILE A 1 472 ? -14.486 -55.458 -12.022 1.00 22.94  ? 735  ILE A CA  1 
ATOM   3459 C  C   . ILE A 1 472 ? -14.602 -54.569 -10.796 1.00 21.20  ? 735  ILE A C   1 
ATOM   3460 O  O   . ILE A 1 472 ? -15.688 -54.569 -10.186 1.00 20.94  ? 735  ILE A O   1 
ATOM   3461 C  CB  . ILE A 1 472 ? -13.789 -56.760 -11.712 1.00 21.29  ? 735  ILE A CB  1 
ATOM   3462 C  CG1 . ILE A 1 472 ? -14.007 -57.636 -12.939 1.00 22.92  ? 735  ILE A CG1 1 
ATOM   3463 C  CG2 . ILE A 1 472 ? -14.320 -57.324 -10.404 1.00 22.74  ? 735  ILE A CG2 1 
ATOM   3464 C  CD1 . ILE A 1 472 ? -13.307 -58.929 -12.897 1.00 27.91  ? 735  ILE A CD1 1 
ATOM   3465 N  N   . GLY A 1 473 ? -13.560 -53.823 -10.495 1.00 20.84  ? 736  GLY A N   1 
ATOM   3466 C  CA  . GLY A 1 473 ? -13.504 -52.919 -9.336  1.00 23.18  ? 736  GLY A CA  1 
ATOM   3467 C  C   . GLY A 1 473 ? -14.546 -51.788 -9.452  1.00 25.35  ? 736  GLY A C   1 
ATOM   3468 O  O   . GLY A 1 473 ? -15.225 -51.464 -8.424  1.00 25.02  ? 736  GLY A O   1 
ATOM   3469 N  N   . ARG A 1 474 ? -14.768 -51.254 -10.650 1.00 22.20  ? 737  ARG A N   1 
ATOM   3470 C  CA  . ARG A 1 474 ? -15.793 -50.185 -10.891 1.00 24.20  ? 737  ARG A CA  1 
ATOM   3471 C  C   . ARG A 1 474 ? -17.229 -50.751 -10.765 1.00 22.78  ? 737  ARG A C   1 
ATOM   3472 O  O   . ARG A 1 474 ? -18.091 -50.105 -10.175 1.00 25.81  ? 737  ARG A O   1 
ATOM   3473 C  CB  . ARG A 1 474 ? -15.663 -49.601 -12.326 1.00 27.22  ? 737  ARG A CB  1 
ATOM   3474 C  CG  . ARG A 1 474 ? -14.298 -49.017 -12.651 1.00 39.82  ? 737  ARG A CG  1 
ATOM   3475 C  CD  . ARG A 1 474 ? -13.940 -48.882 -14.161 1.00 47.12  ? 737  ARG A CD  1 
ATOM   3476 N  NE  . ARG A 1 474 ? -14.452 -47.556 -14.471 1.00 52.85  ? 737  ARG A NE  1 
ATOM   3477 C  CZ  . ARG A 1 474 ? -13.892 -46.429 -14.023 1.00 52.47  ? 737  ARG A CZ  1 
ATOM   3478 N  NH1 . ARG A 1 474 ? -14.469 -45.268 -14.292 1.00 58.44  ? 737  ARG A NH1 1 
ATOM   3479 N  NH2 . ARG A 1 474 ? -12.752 -46.466 -13.344 1.00 44.87  ? 737  ARG A NH2 1 
ATOM   3480 N  N   . ALA A 1 475 ? -17.510 -51.933 -11.324 1.00 21.22  ? 738  ALA A N   1 
ATOM   3481 C  CA  . ALA A 1 475 ? -18.845 -52.564 -11.313 1.00 21.51  ? 738  ALA A CA  1 
ATOM   3482 C  C   . ALA A 1 475 ? -19.223 -52.961 -9.873  1.00 23.53  ? 738  ALA A C   1 
ATOM   3483 O  O   . ALA A 1 475 ? -20.442 -53.038 -9.593  1.00 23.82  ? 738  ALA A O   1 
ATOM   3484 C  CB  . ALA A 1 475 ? -18.858 -53.745 -12.255 1.00 20.06  ? 738  ALA A CB  1 
ATOM   3485 N  N   . ARG A 1 476 ? -18.241 -53.075 -8.956  1.00 22.37  ? 739  ARG A N   1 
ATOM   3486 C  CA  . ARG A 1 476 ? -18.512 -53.429 -7.524  1.00 22.42  ? 739  ARG A CA  1 
ATOM   3487 C  C   . ARG A 1 476 ? -18.843 -52.194 -6.683  1.00 25.80  ? 739  ARG A C   1 
ATOM   3488 O  O   . ARG A 1 476 ? -19.196 -52.357 -5.487  1.00 27.28  ? 739  ARG A O   1 
ATOM   3489 C  CB  . ARG A 1 476 ? -17.377 -54.272 -6.923  1.00 23.02  ? 739  ARG A CB  1 
ATOM   3490 C  CG  . ARG A 1 476 ? -17.376 -55.672 -7.514  1.00 22.86  ? 739  ARG A CG  1 
ATOM   3491 C  CD  . ARG A 1 476 ? -16.078 -56.474 -7.369  1.00 26.84  ? 739  ARG A CD  1 
ATOM   3492 N  NE  . ARG A 1 476 ? -15.625 -56.664 -6.024  1.00 24.22  ? 739  ARG A NE  1 
ATOM   3493 C  CZ  . ARG A 1 476 ? -15.276 -57.807 -5.453  1.00 22.46  ? 739  ARG A CZ  1 
ATOM   3494 N  NH1 . ARG A 1 476 ? -15.473 -58.983 -5.993  1.00 23.96  ? 739  ARG A NH1 1 
ATOM   3495 N  NH2 . ARG A 1 476 ? -14.788 -57.771 -4.240  1.00 24.93  ? 739  ARG A NH2 1 
ATOM   3496 N  N   . ILE A 1 477 ? -18.876 -51.012 -7.292  1.00 26.55  ? 740  ILE A N   1 
ATOM   3497 C  CA  . ILE A 1 477 ? -19.104 -49.749 -6.552  1.00 33.36  ? 740  ILE A CA  1 
ATOM   3498 C  C   . ILE A 1 477 ? -20.416 -49.131 -7.003  1.00 36.10  ? 740  ILE A C   1 
ATOM   3499 O  O   . ILE A 1 477 ? -20.738 -49.154 -8.196  1.00 31.32  ? 740  ILE A O   1 
ATOM   3500 C  CB  . ILE A 1 477 ? -17.934 -48.763 -6.753  1.00 32.88  ? 740  ILE A CB  1 
ATOM   3501 C  CG1 . ILE A 1 477 ? -16.658 -49.289 -6.092  1.00 35.25  ? 740  ILE A CG1 1 
ATOM   3502 C  CG2 . ILE A 1 477 ? -18.302 -47.391 -6.230  1.00 37.99  ? 740  ILE A CG2 1 
ATOM   3503 C  CD1 . ILE A 1 477 ? -15.433 -48.407 -6.348  1.00 38.93  ? 740  ILE A CD1 1 
ATOM   3504 N  N   A SER A 1 478 ? -21.155 -48.612 -6.025  0.25 39.04  ? 741  SER A N   1 
ATOM   3505 N  N   B SER A 1 478 ? -21.196 -48.623 -6.044  0.25 39.79  ? 741  SER A N   1 
ATOM   3506 C  CA  A SER A 1 478 ? -22.346 -47.742 -6.198  0.25 43.68  ? 741  SER A CA  1 
ATOM   3507 C  CA  B SER A 1 478 ? -22.357 -47.719 -6.288  0.25 44.86  ? 741  SER A CA  1 
ATOM   3508 C  C   A SER A 1 478 ? -22.024 -46.367 -5.600  0.25 48.13  ? 741  SER A C   1 
ATOM   3509 C  C   B SER A 1 478 ? -22.183 -46.431 -5.477  0.25 49.47  ? 741  SER A C   1 
ATOM   3510 O  O   A SER A 1 478 ? -21.020 -46.255 -4.853  0.25 47.90  ? 741  SER A O   1 
ATOM   3511 O  O   B SER A 1 478 ? -21.470 -46.451 -4.447  0.25 50.77  ? 741  SER A O   1 
ATOM   3512 C  CB  A SER A 1 478 ? -23.545 -48.395 -5.551  0.25 42.51  ? 741  SER A CB  1 
ATOM   3513 C  CB  B SER A 1 478 ? -23.684 -48.391 -5.998  0.25 44.08  ? 741  SER A CB  1 
ATOM   3514 O  OG  A SER A 1 478 ? -24.707 -47.598 -5.670  0.25 40.30  ? 741  SER A OG  1 
ATOM   3515 O  OG  B SER A 1 478 ? -23.621 -49.251 -4.867  0.25 44.06  ? 741  SER A OG  1 
ATOM   3516 N  N   . GLN A 1 479 ? -22.814 -45.349 -5.936  0.50 56.88  ? 742  GLN A N   1 
ATOM   3517 C  CA  . GLN A 1 479 ? -22.739 -44.006 -5.303  0.50 60.77  ? 742  GLN A CA  1 
ATOM   3518 C  C   . GLN A 1 479 ? -24.128 -43.645 -4.771  0.50 59.87  ? 742  GLN A C   1 
ATOM   3519 O  O   . GLN A 1 479 ? -25.112 -43.885 -5.495  0.50 54.16  ? 742  GLN A O   1 
ATOM   3520 C  CB  . GLN A 1 479 ? -22.238 -42.959 -6.303  0.50 66.05  ? 742  GLN A CB  1 
ATOM   3521 C  CG  . GLN A 1 479 ? -20.940 -43.346 -7.003  0.50 72.52  ? 742  GLN A CG  1 
ATOM   3522 C  CD  . GLN A 1 479 ? -19.730 -43.305 -6.100  0.50 74.19  ? 742  GLN A CD  1 
ATOM   3523 O  OE1 . GLN A 1 479 ? -19.716 -42.638 -5.066  0.50 73.59  ? 742  GLN A OE1 1 
ATOM   3524 N  NE2 . GLN A 1 479 ? -18.688 -44.020 -6.497  0.50 75.02  ? 742  GLN A NE2 1 
ATOM   3525 N  N   . GLY A 1 480 ? -24.194 -43.111 -3.548  0.50 60.98  ? 743  GLY A N   1 
ATOM   3526 C  CA  . GLY A 1 480 ? -25.432 -42.565 -2.957  0.50 61.12  ? 743  GLY A CA  1 
ATOM   3527 C  C   . GLY A 1 480 ? -26.085 -43.515 -1.966  0.50 58.74  ? 743  GLY A C   1 
ATOM   3528 O  O   . GLY A 1 480 ? -25.651 -44.681 -1.869  0.50 54.55  ? 743  GLY A O   1 
ATOM   3529 N  N   . ALA A 1 481 ? -27.109 -43.017 -1.265  1.00 59.21  ? 744  ALA A N   1 
ATOM   3530 C  CA  . ALA A 1 481 ? -27.842 -43.736 -0.202  1.00 57.24  ? 744  ALA A CA  1 
ATOM   3531 C  C   . ALA A 1 481 ? -29.206 -44.211 -0.712  1.00 50.40  ? 744  ALA A C   1 
ATOM   3532 O  O   . ALA A 1 481 ? -29.627 -43.792 -1.797  1.00 42.85  ? 744  ALA A O   1 
ATOM   3533 C  CB  . ALA A 1 481 ? -28.015 -42.791 0.980   1.00 59.94  ? 744  ALA A CB  1 
ATOM   3534 N  N   . GLY A 1 482 ? -29.869 -45.037 0.098   1.00 43.78  ? 745  GLY A N   1 
ATOM   3535 C  CA  . GLY A 1 482 ? -31.275 -45.451 -0.064  1.00 42.53  ? 745  GLY A CA  1 
ATOM   3536 C  C   . GLY A 1 482 ? -31.413 -46.442 -1.192  1.00 40.52  ? 745  GLY A C   1 
ATOM   3537 O  O   . GLY A 1 482 ? -32.481 -46.460 -1.782  1.00 44.09  ? 745  GLY A O   1 
ATOM   3538 N  N   . TRP A 1 483 ? -30.368 -47.233 -1.526  1.00 31.05  ? 746  TRP A N   1 
ATOM   3539 C  CA  . TRP A 1 483 ? -30.546 -48.244 -2.598  1.00 31.98  ? 746  TRP A CA  1 
ATOM   3540 C  C   . TRP A 1 483 ? -31.330 -49.437 -2.047  1.00 30.43  ? 746  TRP A C   1 
ATOM   3541 O  O   . TRP A 1 483 ? -30.869 -50.115 -1.108  1.00 27.05  ? 746  TRP A O   1 
ATOM   3542 C  CB  . TRP A 1 483 ? -29.231 -48.689 -3.209  1.00 37.57  ? 746  TRP A CB  1 
ATOM   3543 C  CG  . TRP A 1 483 ? -28.483 -47.665 -3.997  1.00 44.73  ? 746  TRP A CG  1 
ATOM   3544 C  CD1 . TRP A 1 483 ? -27.715 -46.650 -3.487  1.00 56.38  ? 746  TRP A CD1 1 
ATOM   3545 C  CD2 . TRP A 1 483 ? -28.299 -47.626 -5.420  1.00 42.05  ? 746  TRP A CD2 1 
ATOM   3546 N  NE1 . TRP A 1 483 ? -27.109 -45.946 -4.497  1.00 52.44  ? 746  TRP A NE1 1 
ATOM   3547 C  CE2 . TRP A 1 483 ? -27.433 -46.535 -5.692  1.00 49.63  ? 746  TRP A CE2 1 
ATOM   3548 C  CE3 . TRP A 1 483 ? -28.741 -48.423 -6.482  1.00 36.59  ? 746  TRP A CE3 1 
ATOM   3549 C  CZ2 . TRP A 1 483 ? -27.053 -46.201 -6.993  1.00 49.25  ? 746  TRP A CZ2 1 
ATOM   3550 C  CZ3 . TRP A 1 483 ? -28.373 -48.083 -7.762  1.00 40.71  ? 746  TRP A CZ3 1 
ATOM   3551 C  CH2 . TRP A 1 483 ? -27.565 -46.975 -8.011  1.00 45.56  ? 746  TRP A CH2 1 
ATOM   3552 N  N   . SER A 1 484 ? -32.455 -49.750 -2.654  1.00 26.21  ? 747  SER A N   1 
ATOM   3553 C  CA  . SER A 1 484 ? -33.158 -51.026 -2.395  1.00 25.31  ? 747  SER A CA  1 
ATOM   3554 C  C   . SER A 1 484 ? -32.297 -52.179 -2.928  1.00 23.14  ? 747  SER A C   1 
ATOM   3555 O  O   . SER A 1 484 ? -31.380 -51.886 -3.743  1.00 24.40  ? 747  SER A O   1 
ATOM   3556 C  CB  . SER A 1 484 ? -34.547 -51.009 -2.995  1.00 27.37  ? 747  SER A CB  1 
ATOM   3557 O  OG  . SER A 1 484 ? -34.486 -51.027 -4.407  1.00 24.53  ? 747  SER A OG  1 
ATOM   3558 N  N   . LEU A 1 485 ? -32.654 -53.435 -2.624  1.00 22.98  ? 748  LEU A N   1 
ATOM   3559 C  CA  . LEU A 1 485 ? -31.975 -54.609 -3.227  1.00 25.76  ? 748  LEU A CA  1 
ATOM   3560 C  C   . LEU A 1 485 ? -32.292 -54.647 -4.728  1.00 28.03  ? 748  LEU A C   1 
ATOM   3561 O  O   . LEU A 1 485 ? -31.398 -54.877 -5.542  1.00 25.76  ? 748  LEU A O   1 
ATOM   3562 C  CB  . LEU A 1 485 ? -32.485 -55.875 -2.552  1.00 27.09  ? 748  LEU A CB  1 
ATOM   3563 C  CG  . LEU A 1 485 ? -31.891 -57.151 -3.119  1.00 30.00  ? 748  LEU A CG  1 
ATOM   3564 C  CD1 . LEU A 1 485 ? -30.377 -57.013 -3.206  1.00 31.01  ? 748  LEU A CD1 1 
ATOM   3565 C  CD2 . LEU A 1 485 ? -32.291 -58.347 -2.274  1.00 28.78  ? 748  LEU A CD2 1 
ATOM   3566 N  N   . ARG A 1 486 ? -33.540 -54.315 -5.088  1.00 26.28  ? 749  ARG A N   1 
ATOM   3567 C  CA  . ARG A 1 486 ? -33.965 -54.299 -6.492  1.00 25.77  ? 749  ARG A CA  1 
ATOM   3568 C  C   . ARG A 1 486 ? -33.125 -53.252 -7.230  1.00 24.11  ? 749  ARG A C   1 
ATOM   3569 O  O   . ARG A 1 486 ? -32.691 -53.546 -8.306  1.00 24.28  ? 749  ARG A O   1 
ATOM   3570 C  CB  . ARG A 1 486 ? -35.468 -54.029 -6.617  1.00 28.77  ? 749  ARG A CB  1 
ATOM   3571 C  CG  . ARG A 1 486 ? -35.897 -53.666 -8.034  1.00 31.14  ? 749  ARG A CG  1 
ATOM   3572 C  CD  . ARG A 1 486 ? -37.415 -53.849 -8.127  1.00 31.27  ? 749  ARG A CD  1 
ATOM   3573 N  NE  . ARG A 1 486 ? -37.927 -53.687 -9.510  1.00 29.25  ? 749  ARG A NE  1 
ATOM   3574 C  CZ  . ARG A 1 486 ? -39.060 -54.247 -9.905  1.00 29.95  ? 749  ARG A CZ  1 
ATOM   3575 N  NH1 . ARG A 1 486 ? -39.745 -54.972 -9.028  1.00 26.68  ? 749  ARG A NH1 1 
ATOM   3576 N  NH2 . ARG A 1 486 ? -39.491 -54.116 -11.145 1.00 29.31  ? 749  ARG A NH2 1 
ATOM   3577 N  N   . GLU A 1 487 ? -32.973 -52.040 -6.711  1.00 24.78  ? 750  GLU A N   1 
ATOM   3578 C  CA  . GLU A 1 487 ? -32.197 -51.002 -7.437  1.00 27.08  ? 750  GLU A CA  1 
ATOM   3579 C  C   . GLU A 1 487 ? -30.702 -51.409 -7.552  1.00 26.24  ? 750  GLU A C   1 
ATOM   3580 O  O   . GLU A 1 487 ? -30.073 -51.199 -8.655  1.00 22.07  ? 750  GLU A O   1 
ATOM   3581 C  CB  . GLU A 1 487 ? -32.327 -49.652 -6.746  1.00 35.69  ? 750  GLU A CB  1 
ATOM   3582 C  CG  . GLU A 1 487 ? -32.001 -48.511 -7.700  1.00 46.15  ? 750  GLU A CG  1 
ATOM   3583 C  CD  . GLU A 1 487 ? -31.912 -47.102 -7.112  1.00 53.94  ? 750  GLU A CD  1 
ATOM   3584 O  OE1 . GLU A 1 487 ? -32.228 -46.948 -5.892  1.00 55.90  ? 750  GLU A OE1 1 
ATOM   3585 O  OE2 . GLU A 1 487 ? -31.569 -46.143 -7.898  1.00 49.78  ? 750  GLU A OE2 1 
ATOM   3586 N  N   . THR A 1 488 ? -30.159 -52.050 -6.512  1.00 23.98  ? 751  THR A N   1 
ATOM   3587 C  CA  . THR A 1 488 ? -28.756 -52.552 -6.525  1.00 23.42  ? 751  THR A CA  1 
ATOM   3588 C  C   . THR A 1 488 ? -28.631 -53.626 -7.619  1.00 22.67  ? 751  THR A C   1 
ATOM   3589 O  O   . THR A 1 488 ? -27.605 -53.596 -8.434  1.00 23.96  ? 751  THR A O   1 
ATOM   3590 C  CB  . THR A 1 488 ? -28.350 -53.088 -5.161  1.00 23.90  ? 751  THR A CB  1 
ATOM   3591 O  OG1 . THR A 1 488 ? -28.609 -52.083 -4.170  1.00 25.64  ? 751  THR A OG1 1 
ATOM   3592 C  CG2 . THR A 1 488 ? -26.925 -53.604 -5.149  1.00 23.29  ? 751  THR A CG2 1 
ATOM   3593 N  N   . ALA A 1 489 ? -29.583 -54.565 -7.683  1.00 23.18  ? 752  ALA A N   1 
ATOM   3594 C  CA  . ALA A 1 489 ? -29.612 -55.620 -8.719  1.00 23.50  ? 752  ALA A CA  1 
ATOM   3595 C  C   . ALA A 1 489 ? -29.633 -55.007 -10.129 1.00 24.82  ? 752  ALA A C   1 
ATOM   3596 O  O   . ALA A 1 489 ? -28.940 -55.552 -11.008 1.00 23.40  ? 752  ALA A O   1 
ATOM   3597 C  CB  . ALA A 1 489 ? -30.782 -56.560 -8.521  1.00 24.84  ? 752  ALA A CB  1 
ATOM   3598 N  N   . CYS A 1 490 ? -30.475 -53.990 -10.362 1.00 23.47  ? 753  CYS A N   1 
ATOM   3599 C  CA  . CYS A 1 490 ? -30.664 -53.385 -11.709 1.00 20.44  ? 753  CYS A CA  1 
ATOM   3600 C  C   . CYS A 1 490 ? -29.377 -52.611 -12.098 1.00 22.39  ? 753  CYS A C   1 
ATOM   3601 O  O   . CYS A 1 490 ? -29.037 -52.578 -13.255 1.00 21.78  ? 753  CYS A O   1 
ATOM   3602 C  CB  . CYS A 1 490 ? -31.888 -52.469 -11.729 1.00 21.38  ? 753  CYS A CB  1 
ATOM   3603 S  SG  . CYS A 1 490 ? -33.433 -53.435 -11.625 1.00 27.76  ? 753  CYS A SG  1 
ATOM   3604 N  N   . LEU A 1 491 ? -28.659 -51.999 -11.159 1.00 20.67  ? 754  LEU A N   1 
ATOM   3605 C  CA  . LEU A 1 491 ? -27.311 -51.435 -11.462 1.00 22.44  ? 754  LEU A CA  1 
ATOM   3606 C  C   . LEU A 1 491 ? -26.294 -52.536 -11.818 1.00 24.86  ? 754  LEU A C   1 
ATOM   3607 O  O   . LEU A 1 491 ? -25.565 -52.401 -12.787 1.00 25.73  ? 754  LEU A O   1 
ATOM   3608 C  CB  . LEU A 1 491 ? -26.835 -50.604 -10.278 1.00 25.69  ? 754  LEU A CB  1 
ATOM   3609 C  CG  . LEU A 1 491 ? -25.476 -49.942 -10.506 1.00 28.12  ? 754  LEU A CG  1 
ATOM   3610 C  CD1 . LEU A 1 491 ? -25.523 -49.013 -11.704 1.00 27.39  ? 754  LEU A CD1 1 
ATOM   3611 C  CD2 . LEU A 1 491 ? -24.981 -49.242 -9.255  1.00 28.98  ? 754  LEU A CD2 1 
ATOM   3612 N  N   . GLY A 1 492 ? -26.313 -53.662 -11.124 1.00 24.72  ? 755  GLY A N   1 
ATOM   3613 C  CA  . GLY A 1 492 ? -25.449 -54.792 -11.497 1.00 21.45  ? 755  GLY A CA  1 
ATOM   3614 C  C   . GLY A 1 492 ? -25.735 -55.256 -12.899 1.00 22.62  ? 755  GLY A C   1 
ATOM   3615 O  O   . GLY A 1 492 ? -24.802 -55.520 -13.678 1.00 22.32  ? 755  GLY A O   1 
ATOM   3616 N  N   . LYS A 1 493 ? -27.015 -55.318 -13.240 1.00 22.14  ? 756  LYS A N   1 
ATOM   3617 C  CA  . LYS A 1 493 ? -27.486 -55.712 -14.587 1.00 21.79  ? 756  LYS A CA  1 
ATOM   3618 C  C   . LYS A 1 493 ? -26.982 -54.731 -15.630 1.00 19.61  ? 756  LYS A C   1 
ATOM   3619 O  O   . LYS A 1 493 ? -26.604 -55.221 -16.707 1.00 22.75  ? 756  LYS A O   1 
ATOM   3620 C  CB  . LYS A 1 493 ? -29.028 -55.842 -14.651 1.00 22.87  ? 756  LYS A CB  1 
ATOM   3621 C  CG  . LYS A 1 493 ? -29.561 -56.361 -15.979 1.00 26.27  ? 756  LYS A CG  1 
ATOM   3622 C  CD  . LYS A 1 493 ? -31.040 -56.781 -15.841 1.00 25.71  ? 756  LYS A CD  1 
ATOM   3623 C  CE  . LYS A 1 493 ? -31.680 -57.211 -17.130 1.00 30.61  ? 756  LYS A CE  1 
ATOM   3624 N  NZ  . LYS A 1 493 ? -33.007 -57.821 -16.847 1.00 30.81  ? 756  LYS A NZ  1 
ATOM   3625 N  N   . SER A 1 494 ? -26.993 -53.425 -15.365 1.00 22.11  ? 757  SER A N   1 
ATOM   3626 C  CA  . SER A 1 494 ? -26.410 -52.446 -16.310 1.00 24.53  ? 757  SER A CA  1 
ATOM   3627 C  C   . SER A 1 494 ? -24.940 -52.792 -16.571 1.00 25.58  ? 757  SER A C   1 
ATOM   3628 O  O   . SER A 1 494 ? -24.578 -52.736 -17.744 1.00 21.31  ? 757  SER A O   1 
ATOM   3629 C  CB  . SER A 1 494 ? -26.444 -51.029 -15.863 1.00 24.90  ? 757  SER A CB  1 
ATOM   3630 O  OG  . SER A 1 494 ? -27.770 -50.647 -15.602 1.00 36.28  ? 757  SER A OG  1 
ATOM   3631 N  N   . TYR A 1 495 ? -24.115 -53.044 -15.537 1.00 19.91  ? 758  TYR A N   1 
ATOM   3632 C  CA  . TYR A 1 495 ? -22.681 -53.369 -15.761 1.00 21.94  ? 758  TYR A CA  1 
ATOM   3633 C  C   . TYR A 1 495 ? -22.591 -54.648 -16.589 1.00 20.86  ? 758  TYR A C   1 
ATOM   3634 O  O   . TYR A 1 495 ? -21.761 -54.767 -17.510 1.00 21.42  ? 758  TYR A O   1 
ATOM   3635 C  CB  . TYR A 1 495 ? -21.935 -53.479 -14.430 1.00 23.02  ? 758  TYR A CB  1 
ATOM   3636 C  CG  . TYR A 1 495 ? -21.475 -52.146 -13.935 1.00 23.23  ? 758  TYR A CG  1 
ATOM   3637 C  CD1 . TYR A 1 495 ? -20.351 -51.555 -14.496 1.00 24.61  ? 758  TYR A CD1 1 
ATOM   3638 C  CD2 . TYR A 1 495 ? -22.133 -51.479 -12.908 1.00 25.66  ? 758  TYR A CD2 1 
ATOM   3639 C  CE1 . TYR A 1 495 ? -19.905 -50.317 -14.077 1.00 23.82  ? 758  TYR A CE1 1 
ATOM   3640 C  CE2 . TYR A 1 495 ? -21.683 -50.229 -12.474 1.00 27.43  ? 758  TYR A CE2 1 
ATOM   3641 C  CZ  . TYR A 1 495 ? -20.599 -49.632 -13.105 1.00 29.68  ? 758  TYR A CZ  1 
ATOM   3642 O  OH  . TYR A 1 495 ? -20.125 -48.402 -12.714 1.00 29.11  ? 758  TYR A OH  1 
ATOM   3643 N  N   . ALA A 1 496 ? -23.387 -55.649 -16.242 1.00 20.96  ? 759  ALA A N   1 
ATOM   3644 C  CA  . ALA A 1 496 ? -23.364 -56.961 -16.932 1.00 19.68  ? 759  ALA A CA  1 
ATOM   3645 C  C   . ALA A 1 496 ? -23.641 -56.790 -18.421 1.00 21.49  ? 759  ALA A C   1 
ATOM   3646 O  O   . ALA A 1 496 ? -22.930 -57.403 -19.262 1.00 21.10  ? 759  ALA A O   1 
ATOM   3647 C  CB  . ALA A 1 496 ? -24.350 -57.890 -16.273 1.00 20.75  ? 759  ALA A CB  1 
ATOM   3648 N  N   . GLN A 1 497 ? -24.671 -56.037 -18.782 1.00 21.76  ? 760  GLN A N   1 
ATOM   3649 C  CA  . GLN A 1 497 ? -25.043 -55.859 -20.219 1.00 24.11  ? 760  GLN A CA  1 
ATOM   3650 C  C   . GLN A 1 497 ? -23.956 -55.021 -20.958 1.00 22.37  ? 760  GLN A C   1 
ATOM   3651 O  O   . GLN A 1 497 ? -23.630 -55.328 -22.181 1.00 22.68  ? 760  GLN A O   1 
ATOM   3652 C  CB  . GLN A 1 497 ? -26.463 -55.285 -20.339 1.00 27.50  ? 760  GLN A CB  1 
ATOM   3653 C  CG  . GLN A 1 497 ? -27.512 -56.272 -19.813 1.00 28.65  ? 760  GLN A CG  1 
ATOM   3654 C  CD  . GLN A 1 497 ? -28.983 -56.031 -20.137 1.00 29.83  ? 760  GLN A CD  1 
ATOM   3655 O  OE1 . GLN A 1 497 ? -29.786 -56.972 -20.050 1.00 27.25  ? 760  GLN A OE1 1 
ATOM   3656 N  NE2 . GLN A 1 497 ? -29.320 -54.815 -20.500 1.00 26.90  ? 760  GLN A NE2 1 
ATOM   3657 N  N   . MET A 1 498 ? -23.349 -54.049 -20.259 1.00 20.89  ? 761  MET A N   1 
ATOM   3658 C  CA  . MET A 1 498 ? -22.224 -53.303 -20.849 1.00 20.45  ? 761  MET A CA  1 
ATOM   3659 C  C   . MET A 1 498 ? -21.119 -54.297 -21.161 1.00 18.77  ? 761  MET A C   1 
ATOM   3660 O  O   . MET A 1 498 ? -20.533 -54.266 -22.247 1.00 20.57  ? 761  MET A O   1 
ATOM   3661 C  CB  . MET A 1 498 ? -21.720 -52.190 -19.935 1.00 23.86  ? 761  MET A CB  1 
ATOM   3662 C  CG  . MET A 1 498 ? -20.407 -51.521 -20.486 1.00 27.76  ? 761  MET A CG  1 
ATOM   3663 S  SD  . MET A 1 498 ? -19.878 -50.228 -19.391 1.00 35.62  ? 761  MET A SD  1 
ATOM   3664 C  CE  . MET A 1 498 ? -19.020 -51.230 -18.186 1.00 33.23  ? 761  MET A CE  1 
ATOM   3665 N  N   . TRP A 1 499 ? -20.790 -55.170 -20.233 1.00 20.46  ? 762  TRP A N   1 
ATOM   3666 C  CA  . TRP A 1 499 ? -19.725 -56.159 -20.481 1.00 20.17  ? 762  TRP A CA  1 
ATOM   3667 C  C   . TRP A 1 499 ? -20.059 -57.075 -21.680 1.00 24.72  ? 762  TRP A C   1 
ATOM   3668 O  O   . TRP A 1 499 ? -19.154 -57.338 -22.459 1.00 22.71  ? 762  TRP A O   1 
ATOM   3669 C  CB  . TRP A 1 499 ? -19.482 -56.952 -19.213 1.00 20.38  ? 762  TRP A CB  1 
ATOM   3670 C  CG  . TRP A 1 499 ? -18.858 -56.257 -18.061 1.00 19.01  ? 762  TRP A CG  1 
ATOM   3671 C  CD1 . TRP A 1 499 ? -18.373 -54.989 -17.998 1.00 20.48  ? 762  TRP A CD1 1 
ATOM   3672 C  CD2 . TRP A 1 499 ? -18.698 -56.795 -16.733 1.00 20.21  ? 762  TRP A CD2 1 
ATOM   3673 N  NE1 . TRP A 1 499 ? -17.953 -54.700 -16.736 1.00 21.35  ? 762  TRP A NE1 1 
ATOM   3674 C  CE2 . TRP A 1 499 ? -18.092 -55.800 -15.954 1.00 18.88  ? 762  TRP A CE2 1 
ATOM   3675 C  CE3 . TRP A 1 499 ? -19.005 -57.999 -16.124 1.00 23.92  ? 762  TRP A CE3 1 
ATOM   3676 C  CZ2 . TRP A 1 499 ? -17.718 -55.998 -14.644 1.00 21.27  ? 762  TRP A CZ2 1 
ATOM   3677 C  CZ3 . TRP A 1 499 ? -18.715 -58.175 -14.784 1.00 23.96  ? 762  TRP A CZ3 1 
ATOM   3678 C  CH2 . TRP A 1 499 ? -18.079 -57.184 -14.058 1.00 22.53  ? 762  TRP A CH2 1 
ATOM   3679 N  N   A SER A 1 500 ? -21.309 -57.549 -21.805 0.25 23.05  ? 763  SER A N   1 
ATOM   3680 N  N   B SER A 1 500 ? -21.313 -57.558 -21.810 0.25 23.67  ? 763  SER A N   1 
ATOM   3681 C  CA  A SER A 1 500 ? -21.730 -58.436 -22.918 0.25 22.64  ? 763  SER A CA  1 
ATOM   3682 C  CA  B SER A 1 500 ? -21.728 -58.445 -22.930 0.25 23.70  ? 763  SER A CA  1 
ATOM   3683 C  C   A SER A 1 500 ? -21.567 -57.709 -24.252 0.25 22.17  ? 763  SER A C   1 
ATOM   3684 C  C   B SER A 1 500 ? -21.569 -57.709 -24.259 0.25 22.75  ? 763  SER A C   1 
ATOM   3685 O  O   A SER A 1 500 ? -21.212 -58.369 -25.225 0.25 23.74  ? 763  SER A O   1 
ATOM   3686 O  O   B SER A 1 500 ? -21.242 -58.369 -25.243 0.25 24.36  ? 763  SER A O   1 
ATOM   3687 C  CB  A SER A 1 500 ? -23.130 -58.960 -22.718 0.25 22.24  ? 763  SER A CB  1 
ATOM   3688 C  CB  B SER A 1 500 ? -23.132 -59.018 -22.782 0.25 23.90  ? 763  SER A CB  1 
ATOM   3689 O  OG  A SER A 1 500 ? -23.273 -59.432 -21.385 0.25 22.76  ? 763  SER A OG  1 
ATOM   3690 O  OG  B SER A 1 500 ? -24.114 -57.996 -22.711 0.25 26.61  ? 763  SER A OG  1 
ATOM   3691 N  N   . LEU A 1 501 ? -21.779 -56.394 -24.286 1.00 24.17  ? 764  LEU A N   1 
ATOM   3692 C  CA  . LEU A 1 501 ? -21.674 -55.608 -25.530 1.00 23.53  ? 764  LEU A CA  1 
ATOM   3693 C  C   . LEU A 1 501 ? -20.260 -55.123 -25.869 1.00 25.41  ? 764  LEU A C   1 
ATOM   3694 O  O   . LEU A 1 501 ? -19.926 -55.075 -27.066 1.00 25.38  ? 764  LEU A O   1 
ATOM   3695 C  CB  . LEU A 1 501 ? -22.629 -54.427 -25.363 1.00 28.92  ? 764  LEU A CB  1 
ATOM   3696 C  CG  . LEU A 1 501 ? -23.193 -53.861 -26.642 1.00 40.49  ? 764  LEU A CG  1 
ATOM   3697 C  CD1 . LEU A 1 501 ? -23.653 -54.983 -27.578 1.00 44.06  ? 764  LEU A CD1 1 
ATOM   3698 C  CD2 . LEU A 1 501 ? -24.361 -52.957 -26.275 1.00 44.77  ? 764  LEU A CD2 1 
ATOM   3699 N  N   . MET A 1 502 ? -19.479 -54.679 -24.903 1.00 23.86  ? 765  MET A N   1 
ATOM   3700 C  CA  . MET A 1 502 ? -18.197 -53.998 -25.120 1.00 22.53  ? 765  MET A CA  1 
ATOM   3701 C  C   . MET A 1 502 ? -17.029 -54.970 -24.846 1.00 24.09  ? 765  MET A C   1 
ATOM   3702 O  O   . MET A 1 502 ? -16.052 -54.844 -25.526 1.00 21.71  ? 765  MET A O   1 
ATOM   3703 C  CB  . MET A 1 502 ? -18.098 -52.782 -24.211 1.00 24.99  ? 765  MET A CB  1 
ATOM   3704 C  CG  . MET A 1 502 ? -19.200 -51.756 -24.447 1.00 26.45  ? 765  MET A CG  1 
ATOM   3705 S  SD  . MET A 1 502 ? -19.083 -51.055 -26.117 1.00 34.78  ? 765  MET A SD  1 
ATOM   3706 C  CE  . MET A 1 502 ? -20.214 -52.047 -27.045 1.00 39.82  ? 765  MET A CE  1 
ATOM   3707 N  N   . TYR A 1 503 ? -17.147 -55.877 -23.877 1.00 20.23  ? 766  TYR A N   1 
ATOM   3708 C  CA  . TYR A 1 503 ? -16.003 -56.633 -23.310 1.00 22.13  ? 766  TYR A CA  1 
ATOM   3709 C  C   . TYR A 1 503 ? -16.283 -58.149 -23.403 1.00 23.24  ? 766  TYR A C   1 
ATOM   3710 O  O   . TYR A 1 503 ? -15.717 -58.902 -22.587 1.00 22.25  ? 766  TYR A O   1 
ATOM   3711 C  CB  . TYR A 1 503 ? -15.723 -56.182 -21.878 1.00 24.79  ? 766  TYR A CB  1 
ATOM   3712 C  CG  . TYR A 1 503 ? -15.531 -54.691 -21.657 1.00 23.46  ? 766  TYR A CG  1 
ATOM   3713 C  CD1 . TYR A 1 503 ? -14.547 -53.985 -22.319 1.00 24.20  ? 766  TYR A CD1 1 
ATOM   3714 C  CD2 . TYR A 1 503 ? -16.373 -53.968 -20.842 1.00 27.45  ? 766  TYR A CD2 1 
ATOM   3715 C  CE1 . TYR A 1 503 ? -14.405 -52.618 -22.144 1.00 23.24  ? 766  TYR A CE1 1 
ATOM   3716 C  CE2 . TYR A 1 503 ? -16.254 -52.596 -20.658 1.00 27.62  ? 766  TYR A CE2 1 
ATOM   3717 C  CZ  . TYR A 1 503 ? -15.248 -51.915 -21.306 1.00 26.03  ? 766  TYR A CZ  1 
ATOM   3718 O  OH  . TYR A 1 503 ? -15.082 -50.581 -21.117 1.00 23.83  ? 766  TYR A OH  1 
ATOM   3719 N  N   . PHE A 1 504 ? -17.114 -58.569 -24.367 1.00 22.72  ? 767  PHE A N   1 
ATOM   3720 C  CA  . PHE A 1 504 ? -17.534 -59.986 -24.595 1.00 24.11  ? 767  PHE A CA  1 
ATOM   3721 C  C   . PHE A 1 504 ? -16.317 -60.872 -24.865 1.00 23.74  ? 767  PHE A C   1 
ATOM   3722 O  O   . PHE A 1 504 ? -16.349 -62.109 -24.662 1.00 22.76  ? 767  PHE A O   1 
ATOM   3723 C  CB  . PHE A 1 504 ? -18.466 -60.087 -25.803 1.00 22.58  ? 767  PHE A CB  1 
ATOM   3724 C  CG  . PHE A 1 504 ? -17.976 -59.337 -27.004 1.00 21.57  ? 767  PHE A CG  1 
ATOM   3725 C  CD1 . PHE A 1 504 ? -17.171 -59.961 -27.929 1.00 22.36  ? 767  PHE A CD1 1 
ATOM   3726 C  CD2 . PHE A 1 504 ? -18.310 -58.013 -27.201 1.00 23.07  ? 767  PHE A CD2 1 
ATOM   3727 C  CE1 . PHE A 1 504 ? -16.680 -59.263 -29.003 1.00 21.53  ? 767  PHE A CE1 1 
ATOM   3728 C  CE2 . PHE A 1 504 ? -17.846 -57.335 -28.309 1.00 22.99  ? 767  PHE A CE2 1 
ATOM   3729 C  CZ  . PHE A 1 504 ? -17.030 -57.969 -29.195 1.00 23.02  ? 767  PHE A CZ  1 
ATOM   3730 N  N   . HIS A 1 505 ? -15.242 -60.227 -25.323 1.00 22.48  ? 768  HIS A N   1 
ATOM   3731 C  CA  . HIS A 1 505 ? -13.942 -60.857 -25.714 1.00 21.73  ? 768  HIS A CA  1 
ATOM   3732 C  C   . HIS A 1 505 ? -13.062 -61.235 -24.517 1.00 21.77  ? 768  HIS A C   1 
ATOM   3733 O  O   . HIS A 1 505 ? -11.995 -61.874 -24.706 1.00 21.54  ? 768  HIS A O   1 
ATOM   3734 C  CB  . HIS A 1 505 ? -13.252 -59.990 -26.765 1.00 22.52  ? 768  HIS A CB  1 
ATOM   3735 C  CG  . HIS A 1 505 ? -13.076 -58.577 -26.343 1.00 22.53  ? 768  HIS A CG  1 
ATOM   3736 N  ND1 . HIS A 1 505 ? -12.038 -58.198 -25.524 1.00 21.82  ? 768  HIS A ND1 1 
ATOM   3737 C  CD2 . HIS A 1 505 ? -13.883 -57.499 -26.505 1.00 23.47  ? 768  HIS A CD2 1 
ATOM   3738 C  CE1 . HIS A 1 505 ? -12.157 -56.901 -25.301 1.00 22.24  ? 768  HIS A CE1 1 
ATOM   3739 N  NE2 . HIS A 1 505 ? -13.303 -56.430 -25.862 1.00 21.91  ? 768  HIS A NE2 1 
ATOM   3740 N  N   . ARG A 1 506 ? -13.409 -60.800 -23.310 1.00 18.26  ? 769  ARG A N   1 
ATOM   3741 C  CA  . ARG A 1 506 ? -12.680 -61.148 -22.061 1.00 19.50  ? 769  ARG A CA  1 
ATOM   3742 C  C   . ARG A 1 506 ? -13.438 -62.324 -21.438 1.00 21.12  ? 769  ARG A C   1 
ATOM   3743 O  O   . ARG A 1 506 ? -14.641 -62.122 -21.070 1.00 22.83  ? 769  ARG A O   1 
ATOM   3744 C  CB  . ARG A 1 506 ? -12.715 -59.964 -21.097 1.00 17.82  ? 769  ARG A CB  1 
ATOM   3745 C  CG  . ARG A 1 506 ? -12.247 -58.669 -21.744 1.00 20.05  ? 769  ARG A CG  1 
ATOM   3746 C  CD  . ARG A 1 506 ? -10.873 -58.762 -22.481 1.00 19.88  ? 769  ARG A CD  1 
ATOM   3747 N  NE  . ARG A 1 506 ? -9.939  -59.303 -21.519 1.00 21.89  ? 769  ARG A NE  1 
ATOM   3748 C  CZ  . ARG A 1 506 ? -9.406  -58.641 -20.513 1.00 22.70  ? 769  ARG A CZ  1 
ATOM   3749 N  NH1 . ARG A 1 506 ? -8.670  -59.285 -19.611 1.00 20.97  ? 769  ARG A NH1 1 
ATOM   3750 N  NH2 . ARG A 1 506 ? -9.559  -57.335 -20.430 1.00 21.74  ? 769  ARG A NH2 1 
ATOM   3751 N  N   . ARG A 1 507 ? -12.819 -63.503 -21.378 1.00 21.39  ? 770  ARG A N   1 
ATOM   3752 C  CA  . ARG A 1 507 ? -13.463 -64.717 -20.850 1.00 22.39  ? 770  ARG A CA  1 
ATOM   3753 C  C   . ARG A 1 507 ? -14.187 -64.452 -19.524 1.00 21.46  ? 770  ARG A C   1 
ATOM   3754 O  O   . ARG A 1 507 ? -15.362 -64.861 -19.419 1.00 21.29  ? 770  ARG A O   1 
ATOM   3755 C  CB  . ARG A 1 507 ? -12.465 -65.873 -20.729 1.00 25.30  ? 770  ARG A CB  1 
ATOM   3756 C  CG  . ARG A 1 507 ? -11.948 -66.357 -22.080 1.00 26.64  ? 770  ARG A CG  1 
ATOM   3757 C  CD  . ARG A 1 507 ? -10.682 -67.220 -21.957 1.00 28.20  ? 770  ARG A CD  1 
ATOM   3758 N  NE  . ARG A 1 507 ? -10.304 -67.736 -23.266 1.00 26.18  ? 770  ARG A NE  1 
ATOM   3759 C  CZ  . ARG A 1 507 ? -9.717  -67.020 -24.193 1.00 27.63  ? 770  ARG A CZ  1 
ATOM   3760 N  NH1 . ARG A 1 507 ? -9.336  -65.776 -23.944 1.00 25.79  ? 770  ARG A NH1 1 
ATOM   3761 N  NH2 . ARG A 1 507 ? -9.445  -67.554 -25.367 1.00 26.42  ? 770  ARG A NH2 1 
ATOM   3762 N  N   . ASP A 1 508 ? -13.534 -63.855 -18.530 1.00 20.25  ? 771  ASP A N   1 
ATOM   3763 C  CA  . ASP A 1 508 ? -14.070 -63.710 -17.166 1.00 22.27  ? 771  ASP A CA  1 
ATOM   3764 C  C   . ASP A 1 508 ? -15.304 -62.790 -17.212 1.00 26.41  ? 771  ASP A C   1 
ATOM   3765 O  O   . ASP A 1 508 ? -16.224 -63.025 -16.438 1.00 21.95  ? 771  ASP A O   1 
ATOM   3766 C  CB  . ASP A 1 508 ? -13.028 -63.113 -16.228 1.00 22.42  ? 771  ASP A CB  1 
ATOM   3767 C  CG  . ASP A 1 508 ? -11.829 -64.014 -16.009 1.00 24.01  ? 771  ASP A CG  1 
ATOM   3768 O  OD1 . ASP A 1 508 ? -11.878 -65.198 -16.443 1.00 22.09  ? 771  ASP A OD1 1 
ATOM   3769 O  OD2 . ASP A 1 508 ? -10.852 -63.502 -15.434 1.00 20.63  ? 771  ASP A OD2 1 
ATOM   3770 N  N   . LEU A 1 509 ? -15.328 -61.789 -18.107 1.00 22.74  ? 772  LEU A N   1 
ATOM   3771 C  CA  . LEU A 1 509 ? -16.422 -60.802 -18.057 1.00 23.11  ? 772  LEU A CA  1 
ATOM   3772 C  C   . LEU A 1 509 ? -17.620 -61.402 -18.776 1.00 24.11  ? 772  LEU A C   1 
ATOM   3773 O  O   . LEU A 1 509 ? -18.736 -61.090 -18.390 1.00 21.67  ? 772  LEU A O   1 
ATOM   3774 C  CB  . LEU A 1 509 ? -15.965 -59.465 -18.661 1.00 23.26  ? 772  LEU A CB  1 
ATOM   3775 C  CG  . LEU A 1 509 ? -14.823 -58.741 -17.917 1.00 21.32  ? 772  LEU A CG  1 
ATOM   3776 C  CD1 . LEU A 1 509 ? -14.630 -57.320 -18.460 1.00 23.71  ? 772  LEU A CD1 1 
ATOM   3777 C  CD2 . LEU A 1 509 ? -15.080 -58.663 -16.398 1.00 23.21  ? 772  LEU A CD2 1 
ATOM   3778 N  N   . ARG A 1 510 ? -17.434 -62.197 -19.826 1.00 22.88  ? 773  ARG A N   1 
ATOM   3779 C  CA  . ARG A 1 510 ? -18.629 -62.759 -20.515 1.00 24.96  ? 773  ARG A CA  1 
ATOM   3780 C  C   . ARG A 1 510 ? -19.288 -63.738 -19.541 1.00 27.13  ? 773  ARG A C   1 
ATOM   3781 O  O   . ARG A 1 510 ? -20.516 -63.779 -19.474 1.00 24.65  ? 773  ARG A O   1 
ATOM   3782 C  CB  . ARG A 1 510 ? -18.282 -63.443 -21.820 1.00 22.34  ? 773  ARG A CB  1 
ATOM   3783 C  CG  . ARG A 1 510 ? -19.508 -63.828 -22.640 1.00 26.70  ? 773  ARG A CG  1 
ATOM   3784 C  CD  . ARG A 1 510 ? -19.213 -64.722 -23.820 1.00 24.64  ? 773  ARG A CD  1 
ATOM   3785 N  NE  . ARG A 1 510 ? -18.297 -64.166 -24.770 1.00 23.27  ? 773  ARG A NE  1 
ATOM   3786 C  CZ  . ARG A 1 510 ? -18.170 -64.572 -26.028 1.00 26.24  ? 773  ARG A CZ  1 
ATOM   3787 N  NH1 . ARG A 1 510 ? -18.921 -65.557 -26.510 1.00 26.97  ? 773  ARG A NH1 1 
ATOM   3788 N  NH2 . ARG A 1 510 ? -17.303 -63.979 -26.821 1.00 24.77  ? 773  ARG A NH2 1 
ATOM   3789 N  N   . LEU A 1 511 ? -18.483 -64.498 -18.799 1.00 24.46  ? 774  LEU A N   1 
ATOM   3790 C  CA  . LEU A 1 511 ? -18.993 -65.446 -17.774 1.00 26.23  ? 774  LEU A CA  1 
ATOM   3791 C  C   . LEU A 1 511 ? -19.687 -64.686 -16.637 1.00 25.54  ? 774  LEU A C   1 
ATOM   3792 O  O   . LEU A 1 511 ? -20.816 -65.050 -16.280 1.00 21.01  ? 774  LEU A O   1 
ATOM   3793 C  CB  . LEU A 1 511 ? -17.849 -66.322 -17.241 1.00 26.05  ? 774  LEU A CB  1 
ATOM   3794 C  CG  . LEU A 1 511 ? -18.283 -67.619 -16.553 1.00 27.02  ? 774  LEU A CG  1 
ATOM   3795 C  CD1 . LEU A 1 511 ? -17.158 -68.628 -16.515 1.00 28.30  ? 774  LEU A CD1 1 
ATOM   3796 C  CD2 . LEU A 1 511 ? -18.799 -67.395 -15.151 1.00 29.50  ? 774  LEU A CD2 1 
ATOM   3797 N  N   . ALA A 1 512 ? -19.068 -63.668 -16.073 1.00 23.76  ? 775  ALA A N   1 
ATOM   3798 C  CA  . ALA A 1 512 ? -19.655 -62.925 -14.943 1.00 22.71  ? 775  ALA A CA  1 
ATOM   3799 C  C   . ALA A 1 512 ? -20.942 -62.204 -15.421 1.00 23.66  ? 775  ALA A C   1 
ATOM   3800 O  O   . ALA A 1 512 ? -21.912 -62.162 -14.680 1.00 23.29  ? 775  ALA A O   1 
ATOM   3801 C  CB  . ALA A 1 512 ? -18.670 -61.974 -14.355 1.00 20.48  ? 775  ALA A CB  1 
ATOM   3802 N  N   . ALA A 1 513 ? -20.955 -61.697 -16.638 1.00 21.37  ? 776  ALA A N   1 
ATOM   3803 C  CA  . ALA A 1 513 ? -22.128 -60.987 -17.207 1.00 24.43  ? 776  ALA A CA  1 
ATOM   3804 C  C   . ALA A 1 513 ? -23.301 -61.958 -17.336 1.00 24.24  ? 776  ALA A C   1 
ATOM   3805 O  O   . ALA A 1 513 ? -24.423 -61.593 -16.934 1.00 23.37  ? 776  ALA A O   1 
ATOM   3806 C  CB  . ALA A 1 513 ? -21.820 -60.367 -18.542 1.00 22.95  ? 776  ALA A CB  1 
ATOM   3807 N  N   . ASN A 1 514 ? -23.035 -63.124 -17.914 1.00 22.14  ? 777  ASN A N   1 
ATOM   3808 C  CA  . ASN A 1 514 ? -24.057 -64.206 -17.972 1.00 25.06  ? 777  ASN A CA  1 
ATOM   3809 C  C   . ASN A 1 514 ? -24.547 -64.574 -16.572 1.00 22.18  ? 777  ASN A C   1 
ATOM   3810 O  O   . ASN A 1 514 ? -25.788 -64.692 -16.378 1.00 24.38  ? 777  ASN A O   1 
ATOM   3811 C  CB  . ASN A 1 514 ? -23.529 -65.414 -18.711 1.00 24.68  ? 777  ASN A CB  1 
ATOM   3812 C  CG  . ASN A 1 514 ? -23.459 -65.103 -20.193 1.00 27.94  ? 777  ASN A CG  1 
ATOM   3813 O  OD1 . ASN A 1 514 ? -24.290 -64.386 -20.716 1.00 29.50  ? 777  ASN A OD1 1 
ATOM   3814 N  ND2 . ASN A 1 514 ? -22.509 -65.702 -20.882 1.00 30.06  ? 777  ASN A ND2 1 
ATOM   3815 N  N   . ALA A 1 515 ? -23.658 -64.743 -15.614 1.00 22.56  ? 778  ALA A N   1 
ATOM   3816 C  CA  . ALA A 1 515 ? -24.045 -65.031 -14.215 1.00 21.78  ? 778  ALA A CA  1 
ATOM   3817 C  C   . ALA A 1 515 ? -24.956 -63.927 -13.645 1.00 23.04  ? 778  ALA A C   1 
ATOM   3818 O  O   . ALA A 1 515 ? -25.989 -64.248 -13.036 1.00 23.13  ? 778  ALA A O   1 
ATOM   3819 C  CB  . ALA A 1 515 ? -22.840 -65.263 -13.347 1.00 22.09  ? 778  ALA A CB  1 
ATOM   3820 N  N   . ILE A 1 516 ? -24.547 -62.660 -13.679 1.00 22.77  ? 779  ILE A N   1 
ATOM   3821 C  CA  . ILE A 1 516 ? -25.361 -61.551 -13.131 1.00 23.22  ? 779  ILE A CA  1 
ATOM   3822 C  C   . ILE A 1 516 ? -26.737 -61.553 -13.838 1.00 25.48  ? 779  ILE A C   1 
ATOM   3823 O  O   . ILE A 1 516 ? -27.758 -61.427 -13.136 1.00 25.26  ? 779  ILE A O   1 
ATOM   3824 C  CB  . ILE A 1 516 ? -24.625 -60.208 -13.313 1.00 21.04  ? 779  ILE A CB  1 
ATOM   3825 C  CG1 . ILE A 1 516 ? -23.358 -60.158 -12.479 1.00 21.17  ? 779  ILE A CG1 1 
ATOM   3826 C  CG2 . ILE A 1 516 ? -25.533 -59.053 -12.971 1.00 20.40  ? 779  ILE A CG2 1 
ATOM   3827 C  CD1 . ILE A 1 516 ? -22.396 -59.029 -12.892 1.00 23.40  ? 779  ILE A CD1 1 
ATOM   3828 N  N   . CYS A 1 517 ? -26.793 -61.669 -15.167 1.00 23.79  ? 780  CYS A N   1 
ATOM   3829 C  CA  . CYS A 1 517 ? -28.066 -61.613 -15.935 1.00 26.22  ? 780  CYS A CA  1 
ATOM   3830 C  C   . CYS A 1 517 ? -28.940 -62.819 -15.553 1.00 27.56  ? 780  CYS A C   1 
ATOM   3831 O  O   . CYS A 1 517 ? -30.184 -62.689 -15.600 1.00 27.58  ? 780  CYS A O   1 
ATOM   3832 C  CB  . CYS A 1 517 ? -27.839 -61.500 -17.448 1.00 25.50  ? 780  CYS A CB  1 
ATOM   3833 S  SG  . CYS A 1 517 ? -27.201 -59.853 -17.870 1.00 29.62  ? 780  CYS A SG  1 
ATOM   3834 N  N   . SER A 1 518 ? -28.332 -63.916 -15.108 1.00 23.67  ? 781  SER A N   1 
ATOM   3835 C  CA  . SER A 1 518 ? -29.090 -65.119 -14.675 1.00 25.41  ? 781  SER A CA  1 
ATOM   3836 C  C   . SER A 1 518 ? -29.613 -64.886 -13.253 1.00 25.66  ? 781  SER A C   1 
ATOM   3837 O  O   . SER A 1 518 ? -30.631 -65.533 -12.871 1.00 25.39  ? 781  SER A O   1 
ATOM   3838 C  CB  . SER A 1 518 ? -28.269 -66.374 -14.721 1.00 25.14  ? 781  SER A CB  1 
ATOM   3839 O  OG  . SER A 1 518 ? -27.809 -66.655 -16.027 1.00 27.01  ? 781  SER A OG  1 
ATOM   3840 N  N   . ALA A 1 519 ? -28.931 -64.033 -12.482 1.00 23.54  ? 782  ALA A N   1 
ATOM   3841 C  CA  . ALA A 1 519 ? -29.180 -63.864 -11.031 1.00 23.11  ? 782  ALA A CA  1 
ATOM   3842 C  C   . ALA A 1 519 ? -30.229 -62.784 -10.820 1.00 23.11  ? 782  ALA A C   1 
ATOM   3843 O  O   . ALA A 1 519 ? -30.801 -62.744 -9.721  1.00 25.17  ? 782  ALA A O   1 
ATOM   3844 C  CB  . ALA A 1 519 ? -27.925 -63.596 -10.235 1.00 23.79  ? 782  ALA A CB  1 
ATOM   3845 N  N   . VAL A 1 520 ? -30.397 -61.889 -11.772 1.00 24.14  ? 783  VAL A N   1 
ATOM   3846 C  CA  . VAL A 1 520 ? -31.339 -60.752 -11.634 1.00 25.05  ? 783  VAL A CA  1 
ATOM   3847 C  C   . VAL A 1 520 ? -32.608 -61.117 -12.428 1.00 26.40  ? 783  VAL A C   1 
ATOM   3848 O  O   . VAL A 1 520 ? -32.521 -61.620 -13.571 1.00 24.61  ? 783  VAL A O   1 
ATOM   3849 C  CB  . VAL A 1 520 ? -30.672 -59.455 -12.141 1.00 28.15  ? 783  VAL A CB  1 
ATOM   3850 C  CG1 . VAL A 1 520 ? -31.666 -58.283 -12.176 1.00 25.77  ? 783  VAL A CG1 1 
ATOM   3851 C  CG2 . VAL A 1 520 ? -29.429 -59.089 -11.313 1.00 24.98  ? 783  VAL A CG2 1 
ATOM   3852 N  N   . PRO A 1 521 ? -33.838 -60.827 -11.912 1.00 23.92  ? 784  PRO A N   1 
ATOM   3853 C  CA  . PRO A 1 521 ? -35.045 -61.206 -12.644 1.00 25.19  ? 784  PRO A CA  1 
ATOM   3854 C  C   . PRO A 1 521 ? -34.986 -60.691 -14.089 1.00 26.20  ? 784  PRO A C   1 
ATOM   3855 O  O   . PRO A 1 521 ? -34.612 -59.550 -14.321 1.00 26.84  ? 784  PRO A O   1 
ATOM   3856 C  CB  . PRO A 1 521 ? -36.156 -60.571 -11.770 1.00 22.59  ? 784  PRO A CB  1 
ATOM   3857 C  CG  . PRO A 1 521 ? -35.610 -60.747 -10.333 1.00 24.79  ? 784  PRO A CG  1 
ATOM   3858 C  CD  . PRO A 1 521 ? -34.140 -60.378 -10.532 1.00 24.47  ? 784  PRO A CD  1 
ATOM   3859 N  N   A SER A 1 522 ? -35.369 -61.549 -15.032 0.25 27.93  ? 785  SER A N   1 
ATOM   3860 N  N   B SER A 1 522 ? -35.410 -61.538 -15.024 0.25 27.54  ? 785  SER A N   1 
ATOM   3861 C  CA  A SER A 1 522 ? -35.272 -61.335 -16.503 0.25 30.29  ? 785  SER A CA  1 
ATOM   3862 C  CA  B SER A 1 522 ? -35.270 -61.353 -16.494 0.25 29.70  ? 785  SER A CA  1 
ATOM   3863 C  C   A SER A 1 522 ? -35.859 -59.984 -16.918 0.25 30.62  ? 785  SER A C   1 
ATOM   3864 C  C   B SER A 1 522 ? -35.887 -60.025 -16.954 0.25 30.10  ? 785  SER A C   1 
ATOM   3865 O  O   A SER A 1 522 ? -35.227 -59.302 -17.746 0.25 29.66  ? 785  SER A O   1 
ATOM   3866 O  O   B SER A 1 522 ? -35.280 -59.380 -17.832 0.25 28.90  ? 785  SER A O   1 
ATOM   3867 C  CB  A SER A 1 522 ? -35.982 -62.441 -17.224 0.25 32.48  ? 785  SER A CB  1 
ATOM   3868 C  CB  B SER A 1 522 ? -35.885 -62.527 -17.218 0.25 31.49  ? 785  SER A CB  1 
ATOM   3869 O  OG  A SER A 1 522 ? -37.352 -62.447 -16.855 0.25 34.22  ? 785  SER A OG  1 
ATOM   3870 O  OG  B SER A 1 522 ? -35.907 -63.675 -16.376 0.25 32.34  ? 785  SER A OG  1 
ATOM   3871 N  N   . HIS A 1 523 ? -37.037 -59.625 -16.386 1.00 29.11  ? 786  HIS A N   1 
ATOM   3872 C  CA  . HIS A 1 523 ? -37.796 -58.406 -16.822 1.00 27.71  ? 786  HIS A CA  1 
ATOM   3873 C  C   . HIS A 1 523 ? -37.392 -57.144 -16.070 1.00 26.68  ? 786  HIS A C   1 
ATOM   3874 O  O   . HIS A 1 523 ? -37.825 -56.033 -16.473 1.00 28.04  ? 786  HIS A O   1 
ATOM   3875 C  CB  . HIS A 1 523 ? -39.322 -58.686 -16.781 1.00 32.56  ? 786  HIS A CB  1 
ATOM   3876 C  CG  . HIS A 1 523 ? -39.728 -59.798 -17.697 1.00 29.87  ? 786  HIS A CG  1 
ATOM   3877 N  ND1 . HIS A 1 523 ? -39.813 -59.608 -19.070 1.00 34.65  ? 786  HIS A ND1 1 
ATOM   3878 C  CD2 . HIS A 1 523 ? -39.984 -61.110 -17.486 1.00 37.18  ? 786  HIS A CD2 1 
ATOM   3879 C  CE1 . HIS A 1 523 ? -40.109 -60.760 -19.659 1.00 35.89  ? 786  HIS A CE1 1 
ATOM   3880 N  NE2 . HIS A 1 523 ? -40.249 -61.707 -18.715 1.00 33.01  ? 786  HIS A NE2 1 
ATOM   3881 N  N   . TRP A 1 524 ? -36.542 -57.229 -15.042 1.00 27.45  ? 787  TRP A N   1 
ATOM   3882 C  CA  . TRP A 1 524 ? -36.125 -56.003 -14.326 1.00 27.37  ? 787  TRP A CA  1 
ATOM   3883 C  C   . TRP A 1 524 ? -35.219 -55.175 -15.222 1.00 26.42  ? 787  TRP A C   1 
ATOM   3884 O  O   . TRP A 1 524 ? -34.346 -55.721 -15.907 1.00 29.18  ? 787  TRP A O   1 
ATOM   3885 C  CB  . TRP A 1 524 ? -35.493 -56.330 -12.961 1.00 28.29  ? 787  TRP A CB  1 
ATOM   3886 C  CG  . TRP A 1 524 ? -36.489 -56.771 -11.934 1.00 27.89  ? 787  TRP A CG  1 
ATOM   3887 C  CD1 . TRP A 1 524 ? -37.810 -57.113 -12.137 1.00 28.56  ? 787  TRP A CD1 1 
ATOM   3888 C  CD2 . TRP A 1 524 ? -36.219 -57.039 -10.546 1.00 27.74  ? 787  TRP A CD2 1 
ATOM   3889 N  NE1 . TRP A 1 524 ? -38.363 -57.575 -10.963 1.00 28.32  ? 787  TRP A NE1 1 
ATOM   3890 C  CE2 . TRP A 1 524 ? -37.433 -57.468 -9.955  1.00 28.83  ? 787  TRP A CE2 1 
ATOM   3891 C  CE3 . TRP A 1 524 ? -35.070 -56.961 -9.758  1.00 29.36  ? 787  TRP A CE3 1 
ATOM   3892 C  CZ2 . TRP A 1 524 ? -37.535 -57.777 -8.590  1.00 28.40  ? 787  TRP A CZ2 1 
ATOM   3893 C  CZ3 . TRP A 1 524 ? -35.183 -57.274 -8.405  1.00 32.05  ? 787  TRP A CZ3 1 
ATOM   3894 C  CH2 . TRP A 1 524 ? -36.382 -57.677 -7.833  1.00 26.12  ? 787  TRP A CH2 1 
ATOM   3895 N  N   . VAL A 1 525 ? -35.429 -53.875 -15.165 1.00 27.76  ? 788  VAL A N   1 
ATOM   3896 C  CA  . VAL A 1 525 ? -34.899 -52.906 -16.144 1.00 29.18  ? 788  VAL A CA  1 
ATOM   3897 C  C   . VAL A 1 525 ? -33.568 -52.374 -15.613 1.00 31.32  ? 788  VAL A C   1 
ATOM   3898 O  O   . VAL A 1 525 ? -33.474 -51.787 -14.541 1.00 31.89  ? 788  VAL A O   1 
ATOM   3899 C  CB  . VAL A 1 525 ? -35.895 -51.746 -16.344 1.00 35.23  ? 788  VAL A CB  1 
ATOM   3900 C  CG1 . VAL A 1 525 ? -35.310 -50.658 -17.250 1.00 33.81  ? 788  VAL A CG1 1 
ATOM   3901 C  CG2 . VAL A 1 525 ? -37.276 -52.208 -16.807 1.00 37.55  ? 788  VAL A CG2 1 
ATOM   3902 N  N   . PRO A 1 526 ? -32.482 -52.458 -16.376 1.00 31.57  ? 789  PRO A N   1 
ATOM   3903 C  CA  . PRO A 1 526 ? -31.209 -51.887 -15.922 1.00 29.78  ? 789  PRO A CA  1 
ATOM   3904 C  C   . PRO A 1 526 ? -31.289 -50.396 -15.595 1.00 31.76  ? 789  PRO A C   1 
ATOM   3905 O  O   . PRO A 1 526 ? -31.983 -49.680 -16.327 1.00 33.33  ? 789  PRO A O   1 
ATOM   3906 C  CB  . PRO A 1 526 ? -30.325 -51.988 -17.155 1.00 29.12  ? 789  PRO A CB  1 
ATOM   3907 C  CG  . PRO A 1 526 ? -30.931 -53.058 -17.981 1.00 29.77  ? 789  PRO A CG  1 
ATOM   3908 C  CD  . PRO A 1 526 ? -32.414 -53.052 -17.706 1.00 30.06  ? 789  PRO A CD  1 
ATOM   3909 N  N   . THR A 1 527 ? -30.632 -49.958 -14.523 1.00 36.36  ? 790  THR A N   1 
ATOM   3910 C  CA  . THR A 1 527 ? -30.613 -48.536 -14.108 1.00 40.35  ? 790  THR A CA  1 
ATOM   3911 C  C   . THR A 1 527 ? -29.208 -48.046 -13.834 1.00 47.60  ? 790  THR A C   1 
ATOM   3912 O  O   . THR A 1 527 ? -28.307 -48.866 -13.620 1.00 45.64  ? 790  THR A O   1 
ATOM   3913 C  CB  . THR A 1 527 ? -31.313 -48.207 -12.778 1.00 53.75  ? 790  THR A CB  1 
ATOM   3914 O  OG1 . THR A 1 527 ? -30.894 -49.073 -11.707 1.00 62.68  ? 790  THR A OG1 1 
ATOM   3915 C  CG2 . THR A 1 527 ? -32.808 -48.190 -12.954 1.00 57.16  ? 790  THR A CG2 1 
ATOM   3916 N  N   . SER A 1 528 ? -29.084 -46.734 -13.857 1.00 41.86  ? 791  SER A N   1 
ATOM   3917 C  CA  . SER A 1 528 ? -27.919 -45.937 -13.412 1.00 64.26  ? 791  SER A CA  1 
ATOM   3918 C  C   . SER A 1 528 ? -28.481 -44.623 -12.866 1.00 73.59  ? 791  SER A C   1 
ATOM   3919 O  O   . SER A 1 528 ? -29.500 -44.161 -13.399 1.00 84.70  ? 791  SER A O   1 
ATOM   3920 C  CB  . SER A 1 528 ? -27.004 -45.710 -14.572 1.00 56.26  ? 791  SER A CB  1 
ATOM   3921 O  OG  . SER A 1 528 ? -25.877 -44.972 -14.157 1.00 73.59  ? 791  SER A OG  1 
ATOM   3922 N  N   . ARG A 1 529 ? -27.874 -44.083 -11.803 0.50 72.84  ? 792  ARG A N   1 
ATOM   3923 C  CA  . ARG A 1 529 ? -28.200 -42.743 -11.237 0.50 71.66  ? 792  ARG A CA  1 
ATOM   3924 C  C   . ARG A 1 529 ? -27.352 -41.676 -11.944 0.50 73.53  ? 792  ARG A C   1 
ATOM   3925 O  O   . ARG A 1 529 ? -27.782 -40.508 -11.958 0.50 69.22  ? 792  ARG A O   1 
ATOM   3926 C  CB  . ARG A 1 529 ? -27.967 -42.707 -9.723  0.50 67.12  ? 792  ARG A CB  1 
ATOM   3927 C  CG  . ARG A 1 529 ? -29.063 -43.378 -8.906  0.50 63.73  ? 792  ARG A CG  1 
ATOM   3928 C  CD  . ARG A 1 529 ? -28.975 -43.048 -7.424  0.50 61.25  ? 792  ARG A CD  1 
ATOM   3929 N  NE  . ARG A 1 529 ? -29.641 -44.050 -6.602  0.50 58.08  ? 792  ARG A NE  1 
ATOM   3930 C  CZ  . ARG A 1 529 ? -29.650 -44.055 -5.275  0.50 52.60  ? 792  ARG A CZ  1 
ATOM   3931 N  NH1 . ARG A 1 529 ? -29.035 -43.093 -4.607  0.50 49.02  ? 792  ARG A NH1 1 
ATOM   3932 N  NH2 . ARG A 1 529 ? -30.281 -45.017 -4.625  0.50 51.25  ? 792  ARG A NH2 1 
ATOM   3933 N  N   . THR A 1 530 ? -26.200 -42.067 -12.505 0.50 80.03  ? 793  THR A N   1 
ATOM   3934 C  CA  . THR A 1 530 ? -25.236 -41.167 -13.201 0.50 86.45  ? 793  THR A CA  1 
ATOM   3935 C  C   . THR A 1 530 ? -24.777 -41.797 -14.523 0.50 84.80  ? 793  THR A C   1 
ATOM   3936 O  O   . THR A 1 530 ? -23.798 -41.261 -15.088 0.50 84.33  ? 793  THR A O   1 
ATOM   3937 C  CB  . THR A 1 530 ? -24.018 -40.857 -12.320 0.50 89.03  ? 793  THR A CB  1 
ATOM   3938 O  OG1 . THR A 1 530 ? -23.384 -42.094 -11.990 0.50 86.52  ? 793  THR A OG1 1 
ATOM   3939 C  CG2 . THR A 1 530 ? -24.381 -40.109 -11.056 0.50 88.02  ? 793  THR A CG2 1 
ATOM   3940 N  N   . ALA A 1 536 ? -20.612 -40.862 -24.586 1.00 111.34 ? 799  ALA A N   1 
ATOM   3941 C  CA  . ALA A 1 536 ? -20.793 -42.218 -25.165 1.00 104.47 ? 799  ALA A CA  1 
ATOM   3942 C  C   . ALA A 1 536 ? -22.288 -42.581 -25.261 1.00 97.02  ? 799  ALA A C   1 
ATOM   3943 O  O   . ALA A 1 536 ? -23.113 -42.074 -24.455 1.00 111.05 ? 799  ALA A O   1 
ATOM   3944 C  CB  . ALA A 1 536 ? -20.032 -43.236 -24.339 1.00 100.43 ? 799  ALA A CB  1 
ATOM   3945 N  N   . THR A 1 537 ? -22.623 -43.441 -26.228 0.50 88.34  ? 800  THR A N   1 
ATOM   3946 C  CA  . THR A 1 537 ? -23.980 -44.008 -26.447 0.50 80.29  ? 800  THR A CA  1 
ATOM   3947 C  C   . THR A 1 537 ? -24.116 -45.276 -25.597 0.50 71.21  ? 800  THR A C   1 
ATOM   3948 O  O   . THR A 1 537 ? -23.169 -46.090 -25.615 0.50 74.72  ? 800  THR A O   1 
ATOM   3949 C  CB  . THR A 1 537 ? -24.205 -44.272 -27.940 0.50 83.15  ? 800  THR A CB  1 
ATOM   3950 O  OG1 . THR A 1 537 ? -23.462 -45.435 -28.305 0.50 84.02  ? 800  THR A OG1 1 
ATOM   3951 C  CG2 . THR A 1 537 ? -23.784 -43.104 -28.804 0.50 83.66  ? 800  THR A CG2 1 
ATOM   3952 N  N   A HIS A 1 538 ? -25.226 -45.437 -24.869 0.25 57.44  ? 801  HIS A N   1 
ATOM   3953 N  N   B HIS A 1 538 ? -25.281 -45.424 -24.929 0.25 59.81  ? 801  HIS A N   1 
ATOM   3954 C  CA  A HIS A 1 538 ? -25.388 -46.516 -23.856 0.25 48.91  ? 801  HIS A CA  1 
ATOM   3955 C  CA  B HIS A 1 538 ? -25.521 -46.443 -23.872 0.25 52.38  ? 801  HIS A CA  1 
ATOM   3956 C  C   A HIS A 1 538 ? -26.378 -47.571 -24.368 0.25 42.43  ? 801  HIS A C   1 
ATOM   3957 C  C   B HIS A 1 538 ? -26.430 -47.561 -24.397 0.25 44.12  ? 801  HIS A C   1 
ATOM   3958 O  O   A HIS A 1 538 ? -27.481 -47.694 -23.798 0.25 39.95  ? 801  HIS A O   1 
ATOM   3959 O  O   B HIS A 1 538 ? -27.546 -47.719 -23.859 0.25 41.22  ? 801  HIS A O   1 
ATOM   3960 C  CB  A HIS A 1 538 ? -25.769 -45.908 -22.499 0.25 49.22  ? 801  HIS A CB  1 
ATOM   3961 C  CB  B HIS A 1 538 ? -26.104 -45.769 -22.619 0.25 55.02  ? 801  HIS A CB  1 
ATOM   3962 C  CG  A HIS A 1 538 ? -24.640 -45.209 -21.817 0.25 47.07  ? 801  HIS A CG  1 
ATOM   3963 C  CG  B HIS A 1 538 ? -26.815 -44.486 -22.894 0.25 55.41  ? 801  HIS A CG  1 
ATOM   3964 N  ND1 A HIS A 1 538 ? -24.519 -45.170 -20.438 0.25 48.22  ? 801  HIS A ND1 1 
ATOM   3965 N  ND1 B HIS A 1 538 ? -26.706 -43.388 -22.060 0.25 56.13  ? 801  HIS A ND1 1 
ATOM   3966 C  CD2 A HIS A 1 538 ? -23.576 -44.540 -22.310 0.25 45.84  ? 801  HIS A CD2 1 
ATOM   3967 C  CD2 B HIS A 1 538 ? -27.616 -44.109 -23.914 0.25 56.30  ? 801  HIS A CD2 1 
ATOM   3968 C  CE1 A HIS A 1 538 ? -23.438 -44.489 -20.113 0.25 46.67  ? 801  HIS A CE1 1 
ATOM   3969 C  CE1 B HIS A 1 538 ? -27.424 -42.397 -22.549 0.25 56.29  ? 801  HIS A CE1 1 
ATOM   3970 N  NE2 A HIS A 1 538 ? -22.839 -44.097 -21.245 0.25 45.22  ? 801  HIS A NE2 1 
ATOM   3971 N  NE2 B HIS A 1 538 ? -27.998 -42.815 -23.685 0.25 53.80  ? 801  HIS A NE2 1 
ATOM   3972 N  N   . GLU A 1 539 ? -25.969 -48.341 -25.377 1.00 38.42  ? 802  GLU A N   1 
ATOM   3973 C  CA  . GLU A 1 539 ? -26.838 -49.364 -26.027 1.00 38.60  ? 802  GLU A CA  1 
ATOM   3974 C  C   . GLU A 1 539 ? -27.166 -50.538 -25.108 1.00 37.38  ? 802  GLU A C   1 
ATOM   3975 O  O   . GLU A 1 539 ? -28.125 -51.267 -25.468 1.00 32.50  ? 802  GLU A O   1 
ATOM   3976 C  CB  . GLU A 1 539 ? -26.243 -49.896 -27.315 1.00 45.38  ? 802  GLU A CB  1 
ATOM   3977 C  CG  . GLU A 1 539 ? -26.479 -48.970 -28.481 1.00 50.58  ? 802  GLU A CG  1 
ATOM   3978 C  CD  . GLU A 1 539 ? -25.269 -48.089 -28.568 1.00 61.80  ? 802  GLU A CD  1 
ATOM   3979 O  OE1 . GLU A 1 539 ? -25.034 -47.575 -29.672 1.00 76.80  ? 802  GLU A OE1 1 
ATOM   3980 O  OE2 . GLU A 1 539 ? -24.519 -48.002 -27.529 1.00 66.98  ? 802  GLU A OE2 1 
ATOM   3981 N  N   . TRP A 1 540 ? -26.433 -50.729 -23.989 1.00 28.01  ? 803  TRP A N   1 
ATOM   3982 C  CA  . TRP A 1 540 ? -26.714 -51.828 -23.038 1.00 31.40  ? 803  TRP A CA  1 
ATOM   3983 C  C   . TRP A 1 540 ? -27.876 -51.448 -22.100 1.00 33.26  ? 803  TRP A C   1 
ATOM   3984 O  O   . TRP A 1 540 ? -28.290 -52.260 -21.276 1.00 27.69  ? 803  TRP A O   1 
ATOM   3985 C  CB  . TRP A 1 540 ? -25.403 -52.154 -22.288 1.00 31.45  ? 803  TRP A CB  1 
ATOM   3986 C  CG  . TRP A 1 540 ? -24.803 -51.016 -21.530 1.00 25.66  ? 803  TRP A CG  1 
ATOM   3987 C  CD1 . TRP A 1 540 ? -25.123 -50.620 -20.273 1.00 26.26  ? 803  TRP A CD1 1 
ATOM   3988 C  CD2 . TRP A 1 540 ? -23.797 -50.101 -22.008 1.00 26.88  ? 803  TRP A CD2 1 
ATOM   3989 N  NE1 . TRP A 1 540 ? -24.384 -49.515 -19.927 1.00 30.87  ? 803  TRP A NE1 1 
ATOM   3990 C  CE2 . TRP A 1 540 ? -23.550 -49.185 -20.966 1.00 29.78  ? 803  TRP A CE2 1 
ATOM   3991 C  CE3 . TRP A 1 540 ? -23.073 -49.981 -23.206 1.00 32.35  ? 803  TRP A CE3 1 
ATOM   3992 C  CZ2 . TRP A 1 540 ? -22.605 -48.171 -21.087 1.00 34.71  ? 803  TRP A CZ2 1 
ATOM   3993 C  CZ3 . TRP A 1 540 ? -22.150 -48.972 -23.324 1.00 35.92  ? 803  TRP A CZ3 1 
ATOM   3994 C  CH2 . TRP A 1 540 ? -21.900 -48.094 -22.266 1.00 33.00  ? 803  TRP A CH2 1 
ATOM   3995 N  N   . MET A 1 541 ? -28.365 -50.208 -22.154 1.00 32.14  ? 804  MET A N   1 
ATOM   3996 C  CA  . MET A 1 541 ? -29.419 -49.759 -21.215 1.00 31.86  ? 804  MET A CA  1 
ATOM   3997 C  C   . MET A 1 541 ? -30.775 -50.085 -21.866 1.00 37.20  ? 804  MET A C   1 
ATOM   3998 O  O   . MET A 1 541 ? -31.352 -49.215 -22.529 1.00 35.49  ? 804  MET A O   1 
ATOM   3999 C  CB  . MET A 1 541 ? -29.284 -48.275 -20.875 1.00 35.51  ? 804  MET A CB  1 
ATOM   4000 C  CG  . MET A 1 541 ? -27.999 -47.927 -20.136 1.00 41.56  ? 804  MET A CG  1 
ATOM   4001 S  SD  . MET A 1 541 ? -27.859 -48.800 -18.560 1.00 38.95  ? 804  MET A SD  1 
ATOM   4002 C  CE  . MET A 1 541 ? -29.109 -47.921 -17.629 1.00 44.01  ? 804  MET A CE  1 
ATOM   4003 N  N   . THR A 1 542 ? -31.226 -51.332 -21.743 1.00 33.83  ? 805  THR A N   1 
ATOM   4004 C  CA  . THR A 1 542 ? -32.364 -51.899 -22.529 1.00 35.39  ? 805  THR A CA  1 
ATOM   4005 C  C   . THR A 1 542 ? -32.758 -53.246 -21.938 1.00 34.70  ? 805  THR A C   1 
ATOM   4006 O  O   . THR A 1 542 ? -31.893 -53.878 -21.287 1.00 28.01  ? 805  THR A O   1 
ATOM   4007 C  CB  . THR A 1 542 ? -32.016 -52.055 -24.013 1.00 42.88  ? 805  THR A CB  1 
ATOM   4008 O  OG1 . THR A 1 542 ? -33.092 -52.685 -24.716 1.00 42.16  ? 805  THR A OG1 1 
ATOM   4009 C  CG2 . THR A 1 542 ? -30.773 -52.894 -24.218 1.00 48.67  ? 805  THR A CG2 1 
ATOM   4010 N  N   . THR A 1 543 ? -34.001 -53.690 -22.137 1.00 30.12  ? 806  THR A N   1 
ATOM   4011 C  CA  . THR A 1 543 ? -34.447 -55.063 -21.783 1.00 32.91  ? 806  THR A CA  1 
ATOM   4012 C  C   . THR A 1 543 ? -34.525 -55.939 -23.044 1.00 32.80  ? 806  THR A C   1 
ATOM   4013 O  O   . THR A 1 543 ? -34.801 -57.125 -22.919 1.00 33.34  ? 806  THR A O   1 
ATOM   4014 C  CB  . THR A 1 543 ? -35.789 -55.005 -21.030 1.00 45.61  ? 806  THR A CB  1 
ATOM   4015 O  OG1 . THR A 1 543 ? -36.707 -54.315 -21.870 1.00 38.24  ? 806  THR A OG1 1 
ATOM   4016 C  CG2 . THR A 1 543 ? -35.692 -54.256 -19.714 1.00 46.41  ? 806  THR A CG2 1 
ATOM   4017 N  N   . GLU A 1 544 ? -34.166 -55.417 -24.213 1.00 31.81  ? 807  GLU A N   1 
ATOM   4018 C  CA  . GLU A 1 544 ? -33.982 -56.247 -25.434 1.00 32.85  ? 807  GLU A CA  1 
ATOM   4019 C  C   . GLU A 1 544 ? -32.912 -57.327 -25.190 1.00 33.79  ? 807  GLU A C   1 
ATOM   4020 O  O   . GLU A 1 544 ? -32.062 -57.173 -24.307 1.00 31.90  ? 807  GLU A O   1 
ATOM   4021 C  CB  . GLU A 1 544 ? -33.627 -55.337 -26.586 1.00 39.94  ? 807  GLU A CB  1 
ATOM   4022 C  CG  . GLU A 1 544 ? -33.660 -56.023 -27.923 1.00 48.96  ? 807  GLU A CG  1 
ATOM   4023 C  CD  . GLU A 1 544 ? -33.650 -55.011 -29.060 1.00 56.72  ? 807  GLU A CD  1 
ATOM   4024 O  OE1 . GLU A 1 544 ? -34.157 -55.362 -30.158 1.00 59.99  ? 807  GLU A OE1 1 
ATOM   4025 O  OE2 . GLU A 1 544 ? -33.188 -53.845 -28.823 1.00 49.09  ? 807  GLU A OE2 1 
ATOM   4026 N  N   . ASP A 1 545 ? -33.063 -58.460 -25.842 1.00 32.01  ? 808  ASP A N   1 
ATOM   4027 C  CA  . ASP A 1 545 ? -32.134 -59.606 -25.829 1.00 37.15  ? 808  ASP A CA  1 
ATOM   4028 C  C   . ASP A 1 545 ? -30.717 -59.119 -26.225 1.00 30.71  ? 808  ASP A C   1 
ATOM   4029 O  O   . ASP A 1 545 ? -30.589 -58.450 -27.278 1.00 29.24  ? 808  ASP A O   1 
ATOM   4030 C  CB  . ASP A 1 545 ? -32.671 -60.647 -26.792 1.00 44.21  ? 808  ASP A CB  1 
ATOM   4031 C  CG  . ASP A 1 545 ? -31.863 -61.917 -26.866 1.00 48.93  ? 808  ASP A CG  1 
ATOM   4032 O  OD1 . ASP A 1 545 ? -30.741 -61.843 -27.349 1.00 58.70  ? 808  ASP A OD1 1 
ATOM   4033 O  OD2 . ASP A 1 545 ? -32.396 -62.970 -26.473 1.00 71.64  ? 808  ASP A OD2 1 
ATOM   4034 N  N   . MET A 1 546 ? -29.676 -59.496 -25.462 1.00 29.97  ? 809  MET A N   1 
ATOM   4035 C  CA  . MET A 1 546 ? -28.303 -58.917 -25.680 1.00 31.02  ? 809  MET A CA  1 
ATOM   4036 C  C   . MET A 1 546 ? -27.703 -59.445 -26.985 1.00 28.61  ? 809  MET A C   1 
ATOM   4037 O  O   . MET A 1 546 ? -26.923 -58.687 -27.588 1.00 26.41  ? 809  MET A O   1 
ATOM   4038 C  CB  . MET A 1 546 ? -27.377 -59.095 -24.471 1.00 31.05  ? 809  MET A CB  1 
ATOM   4039 C  CG  . MET A 1 546 ? -27.711 -58.109 -23.341 1.00 27.63  ? 809  MET A CG  1 
ATOM   4040 S  SD  . MET A 1 546 ? -27.614 -56.295 -23.762 1.00 39.48  ? 809  MET A SD  1 
ATOM   4041 C  CE  . MET A 1 546 ? -29.251 -55.833 -24.268 1.00 50.64  ? 809  MET A CE  1 
ATOM   4042 N  N   . LEU A 1 547 ? -28.109 -60.624 -27.483 1.00 24.95  ? 810  LEU A N   1 
ATOM   4043 C  CA  . LEU A 1 547 ? -27.579 -61.098 -28.793 1.00 29.61  ? 810  LEU A CA  1 
ATOM   4044 C  C   . LEU A 1 547 ? -28.137 -60.201 -29.900 1.00 31.73  ? 810  LEU A C   1 
ATOM   4045 O  O   . LEU A 1 547 ? -27.391 -59.913 -30.831 1.00 26.67  ? 810  LEU A O   1 
ATOM   4046 C  CB  . LEU A 1 547 ? -27.899 -62.559 -29.105 1.00 33.03  ? 810  LEU A CB  1 
ATOM   4047 C  CG  . LEU A 1 547 ? -27.187 -63.129 -30.337 1.00 35.23  ? 810  LEU A CG  1 
ATOM   4048 C  CD1 . LEU A 1 547 ? -25.659 -63.128 -30.189 1.00 33.57  ? 810  LEU A CD1 1 
ATOM   4049 C  CD2 . LEU A 1 547 ? -27.656 -64.541 -30.568 1.00 37.41  ? 810  LEU A CD2 1 
ATOM   4050 N  N   . THR A 1 548 ? -29.398 -59.787 -29.810 1.00 28.86  ? 811  THR A N   1 
ATOM   4051 C  CA  . THR A 1 548 ? -30.032 -58.922 -30.825 1.00 30.41  ? 811  THR A CA  1 
ATOM   4052 C  C   . THR A 1 548 ? -29.324 -57.551 -30.846 1.00 29.27  ? 811  THR A C   1 
ATOM   4053 O  O   . THR A 1 548 ? -29.063 -57.024 -31.919 1.00 28.08  ? 811  THR A O   1 
ATOM   4054 C  CB  . THR A 1 548 ? -31.548 -58.808 -30.577 1.00 32.31  ? 811  THR A CB  1 
ATOM   4055 O  OG1 . THR A 1 548 ? -32.125 -60.123 -30.609 1.00 31.01  ? 811  THR A OG1 1 
ATOM   4056 C  CG2 . THR A 1 548 ? -32.193 -57.898 -31.602 1.00 32.24  ? 811  THR A CG2 1 
ATOM   4057 N  N   . VAL A 1 549 ? -29.071 -56.971 -29.683 1.00 24.30  ? 812  VAL A N   1 
ATOM   4058 C  CA  . VAL A 1 549 ? -28.340 -55.692 -29.545 1.00 27.12  ? 812  VAL A CA  1 
ATOM   4059 C  C   . VAL A 1 549 ? -26.907 -55.855 -30.082 1.00 25.21  ? 812  VAL A C   1 
ATOM   4060 O  O   . VAL A 1 549 ? -26.423 -54.909 -30.767 1.00 26.04  ? 812  VAL A O   1 
ATOM   4061 C  CB  . VAL A 1 549 ? -28.366 -55.180 -28.094 1.00 30.06  ? 812  VAL A CB  1 
ATOM   4062 C  CG1 . VAL A 1 549 ? -27.628 -53.847 -28.000 1.00 31.65  ? 812  VAL A CG1 1 
ATOM   4063 C  CG2 . VAL A 1 549 ? -29.799 -55.069 -27.547 1.00 34.57  ? 812  VAL A CG2 1 
ATOM   4064 N  N   . TRP A 1 550 ? -26.233 -56.967 -29.787 1.00 27.46  ? 813  TRP A N   1 
ATOM   4065 C  CA  . TRP A 1 550 ? -24.847 -57.223 -30.259 1.00 23.74  ? 813  TRP A CA  1 
ATOM   4066 C  C   . TRP A 1 550 ? -24.875 -57.189 -31.799 1.00 29.51  ? 813  TRP A C   1 
ATOM   4067 O  O   . TRP A 1 550 ? -24.029 -56.496 -32.430 1.00 28.67  ? 813  TRP A O   1 
ATOM   4068 C  CB  . TRP A 1 550 ? -24.297 -58.535 -29.684 1.00 23.34  ? 813  TRP A CB  1 
ATOM   4069 C  CG  . TRP A 1 550 ? -22.838 -58.696 -29.960 1.00 24.40  ? 813  TRP A CG  1 
ATOM   4070 C  CD1 . TRP A 1 550 ? -21.808 -58.466 -29.086 1.00 27.47  ? 813  TRP A CD1 1 
ATOM   4071 C  CD2 . TRP A 1 550 ? -22.215 -59.056 -31.195 1.00 23.99  ? 813  TRP A CD2 1 
ATOM   4072 N  NE1 . TRP A 1 550 ? -20.594 -58.709 -29.659 1.00 25.93  ? 813  TRP A NE1 1 
ATOM   4073 C  CE2 . TRP A 1 550 ? -20.811 -59.064 -30.965 1.00 25.94  ? 813  TRP A CE2 1 
ATOM   4074 C  CE3 . TRP A 1 550 ? -22.690 -59.496 -32.430 1.00 25.48  ? 813  TRP A CE3 1 
ATOM   4075 C  CZ2 . TRP A 1 550 ? -19.879 -59.418 -31.934 1.00 25.18  ? 813  TRP A CZ2 1 
ATOM   4076 C  CZ3 . TRP A 1 550 ? -21.765 -59.823 -33.402 1.00 25.20  ? 813  TRP A CZ3 1 
ATOM   4077 C  CH2 . TRP A 1 550 ? -20.395 -59.784 -33.163 1.00 24.44  ? 813  TRP A CH2 1 
ATOM   4078 N  N   . ASN A 1 551 ? -25.833 -57.881 -32.413 1.00 26.71  ? 814  ASN A N   1 
ATOM   4079 C  CA  . ASN A 1 551 ? -25.953 -57.908 -33.895 1.00 28.81  ? 814  ASN A CA  1 
ATOM   4080 C  C   . ASN A 1 551 ? -26.179 -56.501 -34.442 1.00 24.46  ? 814  ASN A C   1 
ATOM   4081 O  O   . ASN A 1 551 ? -25.556 -56.176 -35.468 1.00 29.19  ? 814  ASN A O   1 
ATOM   4082 C  CB  . ASN A 1 551 ? -27.032 -58.864 -34.422 1.00 30.82  ? 814  ASN A CB  1 
ATOM   4083 C  CG  . ASN A 1 551 ? -26.498 -60.261 -34.590 1.00 35.05  ? 814  ASN A CG  1 
ATOM   4084 O  OD1 . ASN A 1 551 ? -25.563 -60.500 -35.360 1.00 40.29  ? 814  ASN A OD1 1 
ATOM   4085 N  ND2 . ASN A 1 551 ? -27.064 -61.210 -33.859 1.00 40.67  ? 814  ASN A ND2 1 
ATOM   4086 N  N   . ARG A 1 552 ? -27.048 -55.714 -33.827 1.00 27.30  ? 815  ARG A N   1 
ATOM   4087 C  CA  . ARG A 1 552 ? -27.341 -54.365 -34.307 1.00 27.58  ? 815  ARG A CA  1 
ATOM   4088 C  C   . ARG A 1 552 ? -26.056 -53.512 -34.232 1.00 31.20  ? 815  ARG A C   1 
ATOM   4089 O  O   . ARG A 1 552 ? -25.715 -52.876 -35.232 1.00 36.30  ? 815  ARG A O   1 
ATOM   4090 C  CB  . ARG A 1 552 ? -28.501 -53.767 -33.529 1.00 29.22  ? 815  ARG A CB  1 
ATOM   4091 C  CG  . ARG A 1 552 ? -28.998 -52.455 -34.111 1.00 33.39  ? 815  ARG A CG  1 
ATOM   4092 C  CD  . ARG A 1 552 ? -29.975 -51.755 -33.180 1.00 40.50  ? 815  ARG A CD  1 
ATOM   4093 N  NE  . ARG A 1 552 ? -31.099 -52.673 -33.014 1.00 52.76  ? 815  ARG A NE  1 
ATOM   4094 C  CZ  . ARG A 1 552 ? -31.632 -53.109 -31.857 1.00 50.38  ? 815  ARG A CZ  1 
ATOM   4095 N  NH1 . ARG A 1 552 ? -31.213 -52.681 -30.675 1.00 47.82  ? 815  ARG A NH1 1 
ATOM   4096 N  NH2 . ARG A 1 552 ? -32.662 -53.928 -31.926 1.00 55.76  ? 815  ARG A NH2 1 
ATOM   4097 N  N   . VAL A 1 553 ? -25.323 -53.554 -33.122 1.00 30.16  ? 816  VAL A N   1 
ATOM   4098 C  CA  . VAL A 1 553 ? -24.167 -52.645 -32.871 1.00 29.65  ? 816  VAL A CA  1 
ATOM   4099 C  C   . VAL A 1 553 ? -22.948 -53.099 -33.704 1.00 27.31  ? 816  VAL A C   1 
ATOM   4100 O  O   . VAL A 1 553 ? -22.290 -52.260 -34.332 1.00 32.07  ? 816  VAL A O   1 
ATOM   4101 C  CB  . VAL A 1 553 ? -23.899 -52.607 -31.352 1.00 29.02  ? 816  VAL A CB  1 
ATOM   4102 C  CG1 . VAL A 1 553 ? -22.562 -51.990 -31.055 1.00 28.81  ? 816  VAL A CG1 1 
ATOM   4103 C  CG2 . VAL A 1 553 ? -25.026 -51.857 -30.657 1.00 29.54  ? 816  VAL A CG2 1 
ATOM   4104 N  N   . TRP A 1 554 ? -22.601 -54.384 -33.712 1.00 24.85  ? 817  TRP A N   1 
ATOM   4105 C  CA  . TRP A 1 554 ? -21.320 -54.845 -34.266 1.00 23.35  ? 817  TRP A CA  1 
ATOM   4106 C  C   . TRP A 1 554 ? -21.457 -55.234 -35.740 1.00 29.62  ? 817  TRP A C   1 
ATOM   4107 O  O   . TRP A 1 554 ? -20.412 -55.317 -36.374 1.00 27.49  ? 817  TRP A O   1 
ATOM   4108 C  CB  . TRP A 1 554 ? -20.753 -55.981 -33.413 1.00 26.60  ? 817  TRP A CB  1 
ATOM   4109 C  CG  . TRP A 1 554 ? -20.237 -55.512 -32.077 1.00 26.29  ? 817  TRP A CG  1 
ATOM   4110 C  CD1 . TRP A 1 554 ? -20.842 -55.605 -30.867 1.00 26.67  ? 817  TRP A CD1 1 
ATOM   4111 C  CD2 . TRP A 1 554 ? -19.021 -54.765 -31.853 1.00 22.71  ? 817  TRP A CD2 1 
ATOM   4112 N  NE1 . TRP A 1 554 ? -20.063 -55.028 -29.894 1.00 26.19  ? 817  TRP A NE1 1 
ATOM   4113 C  CE2 . TRP A 1 554 ? -18.937 -54.506 -30.470 1.00 25.48  ? 817  TRP A CE2 1 
ATOM   4114 C  CE3 . TRP A 1 554 ? -17.986 -54.344 -32.677 1.00 23.35  ? 817  TRP A CE3 1 
ATOM   4115 C  CZ2 . TRP A 1 554 ? -17.868 -53.819 -29.898 1.00 24.08  ? 817  TRP A CZ2 1 
ATOM   4116 C  CZ3 . TRP A 1 554 ? -16.919 -53.644 -32.110 1.00 23.51  ? 817  TRP A CZ3 1 
ATOM   4117 C  CH2 . TRP A 1 554 ? -16.871 -53.399 -30.748 1.00 22.71  ? 817  TRP A CH2 1 
ATOM   4118 N  N   . ILE A 1 555 ? -22.680 -55.526 -36.250 1.00 28.36  ? 818  ILE A N   1 
ATOM   4119 C  CA  . ILE A 1 555 ? -22.854 -56.004 -37.650 1.00 29.90  ? 818  ILE A CA  1 
ATOM   4120 C  C   . ILE A 1 555 ? -23.695 -54.966 -38.380 1.00 31.41  ? 818  ILE A C   1 
ATOM   4121 O  O   . ILE A 1 555 ? -23.140 -54.298 -39.256 1.00 29.34  ? 818  ILE A O   1 
ATOM   4122 C  CB  . ILE A 1 555 ? -23.500 -57.404 -37.730 1.00 30.93  ? 818  ILE A CB  1 
ATOM   4123 C  CG1 . ILE A 1 555 ? -22.785 -58.471 -36.908 1.00 31.14  ? 818  ILE A CG1 1 
ATOM   4124 C  CG2 . ILE A 1 555 ? -23.618 -57.841 -39.195 1.00 30.75  ? 818  ILE A CG2 1 
ATOM   4125 C  CD1 . ILE A 1 555 ? -21.331 -58.529 -37.137 1.00 34.95  ? 818  ILE A CD1 1 
ATOM   4126 N  N   . GLN A 1 556 ? -24.989 -54.848 -38.047 1.00 36.16  ? 819  GLN A N   1 
ATOM   4127 C  CA  . GLN A 1 556 ? -25.989 -54.135 -38.889 1.00 35.56  ? 819  GLN A CA  1 
ATOM   4128 C  C   . GLN A 1 556 ? -25.569 -52.664 -39.014 1.00 35.85  ? 819  GLN A C   1 
ATOM   4129 O  O   . GLN A 1 556 ? -25.468 -52.184 -40.149 1.00 35.68  ? 819  GLN A O   1 
ATOM   4130 C  CB  . GLN A 1 556 ? -27.399 -54.334 -38.300 1.00 40.66  ? 819  GLN A CB  1 
ATOM   4131 C  CG  . GLN A 1 556 ? -28.522 -53.709 -39.140 1.00 49.88  ? 819  GLN A CG  1 
ATOM   4132 C  CD  . GLN A 1 556 ? -29.791 -53.427 -38.357 1.00 61.45  ? 819  GLN A CD  1 
ATOM   4133 O  OE1 . GLN A 1 556 ? -30.337 -52.319 -38.380 1.00 66.78  ? 819  GLN A OE1 1 
ATOM   4134 N  NE2 . GLN A 1 556 ? -30.259 -54.415 -37.607 1.00 54.21  ? 819  GLN A NE2 1 
ATOM   4135 N  N   . GLU A 1 557 ? -25.337 -51.953 -37.905 1.00 29.17  ? 820  GLU A N   1 
ATOM   4136 C  CA  . GLU A 1 557 ? -25.112 -50.490 -37.900 1.00 31.58  ? 820  GLU A CA  1 
ATOM   4137 C  C   . GLU A 1 557 ? -23.597 -50.167 -37.966 1.00 31.55  ? 820  GLU A C   1 
ATOM   4138 O  O   . GLU A 1 557 ? -23.212 -48.977 -37.844 1.00 35.51  ? 820  GLU A O   1 
ATOM   4139 C  CB  . GLU A 1 557 ? -25.806 -49.846 -36.697 1.00 32.94  ? 820  GLU A CB  1 
ATOM   4140 C  CG  . GLU A 1 557 ? -27.312 -50.070 -36.691 1.00 44.65  ? 820  GLU A CG  1 
ATOM   4141 C  CD  . GLU A 1 557 ? -28.146 -49.392 -35.597 1.00 55.59  ? 820  GLU A CD  1 
ATOM   4142 O  OE1 . GLU A 1 557 ? -27.591 -49.011 -34.511 1.00 56.79  ? 820  GLU A OE1 1 
ATOM   4143 O  OE2 . GLU A 1 557 ? -29.392 -49.256 -35.819 1.00 70.62  ? 820  GLU A OE2 1 
ATOM   4144 N  N   . ASN A 1 558 ? -22.746 -51.160 -38.141 1.00 30.03  ? 821  ASN A N   1 
ATOM   4145 C  CA  . ASN A 1 558 ? -21.268 -50.966 -38.109 1.00 31.53  ? 821  ASN A CA  1 
ATOM   4146 C  C   . ASN A 1 558 ? -20.795 -50.589 -39.515 1.00 30.81  ? 821  ASN A C   1 
ATOM   4147 O  O   . ASN A 1 558 ? -20.692 -51.442 -40.387 1.00 31.37  ? 821  ASN A O   1 
ATOM   4148 C  CB  . ASN A 1 558 ? -20.587 -52.228 -37.589 1.00 32.65  ? 821  ASN A CB  1 
ATOM   4149 C  CG  . ASN A 1 558 ? -19.074 -52.183 -37.515 1.00 28.72  ? 821  ASN A CG  1 
ATOM   4150 O  OD1 . ASN A 1 558 ? -18.465 -51.205 -37.930 1.00 28.36  ? 821  ASN A OD1 1 
ATOM   4151 N  ND2 . ASN A 1 558 ? -18.470 -53.266 -37.014 1.00 25.86  ? 821  ASN A ND2 1 
ATOM   4152 N  N   . PRO A 1 559 ? -20.403 -49.327 -39.765 1.00 32.10  ? 822  PRO A N   1 
ATOM   4153 C  CA  . PRO A 1 559 ? -19.997 -48.932 -41.114 1.00 33.34  ? 822  PRO A CA  1 
ATOM   4154 C  C   . PRO A 1 559 ? -18.674 -49.570 -41.543 1.00 33.42  ? 822  PRO A C   1 
ATOM   4155 O  O   . PRO A 1 559 ? -18.358 -49.532 -42.702 1.00 34.65  ? 822  PRO A O   1 
ATOM   4156 C  CB  . PRO A 1 559 ? -19.941 -47.397 -41.031 1.00 35.87  ? 822  PRO A CB  1 
ATOM   4157 C  CG  . PRO A 1 559 ? -19.687 -47.116 -39.581 1.00 36.31  ? 822  PRO A CG  1 
ATOM   4158 C  CD  . PRO A 1 559 ? -20.440 -48.199 -38.826 1.00 34.65  ? 822  PRO A CD  1 
ATOM   4159 N  N   . TRP A 1 560 ? -17.923 -50.214 -40.643 1.00 31.52  ? 823  TRP A N   1 
ATOM   4160 C  CA  . TRP A 1 560 ? -16.667 -50.902 -41.046 1.00 33.08  ? 823  TRP A CA  1 
ATOM   4161 C  C   . TRP A 1 560 ? -16.881 -52.381 -41.418 1.00 34.29  ? 823  TRP A C   1 
ATOM   4162 O  O   . TRP A 1 560 ? -15.873 -52.993 -41.774 1.00 37.98  ? 823  TRP A O   1 
ATOM   4163 C  CB  . TRP A 1 560 ? -15.611 -50.733 -39.926 1.00 30.76  ? 823  TRP A CB  1 
ATOM   4164 C  CG  . TRP A 1 560 ? -15.141 -49.318 -39.817 1.00 30.51  ? 823  TRP A CG  1 
ATOM   4165 C  CD1 . TRP A 1 560 ? -14.179 -48.705 -40.572 1.00 28.82  ? 823  TRP A CD1 1 
ATOM   4166 C  CD2 . TRP A 1 560 ? -15.647 -48.321 -38.916 1.00 28.74  ? 823  TRP A CD2 1 
ATOM   4167 N  NE1 . TRP A 1 560 ? -14.043 -47.399 -40.173 1.00 33.44  ? 823  TRP A NE1 1 
ATOM   4168 C  CE2 . TRP A 1 560 ? -14.948 -47.131 -39.172 1.00 27.65  ? 823  TRP A CE2 1 
ATOM   4169 C  CE3 . TRP A 1 560 ? -16.587 -48.341 -37.892 1.00 27.43  ? 823  TRP A CE3 1 
ATOM   4170 C  CZ2 . TRP A 1 560 ? -15.156 -45.979 -38.426 1.00 28.18  ? 823  TRP A CZ2 1 
ATOM   4171 C  CZ3 . TRP A 1 560 ? -16.824 -47.202 -37.180 1.00 28.80  ? 823  TRP A CZ3 1 
ATOM   4172 C  CH2 . TRP A 1 560 ? -16.117 -46.027 -37.443 1.00 29.04  ? 823  TRP A CH2 1 
ATOM   4173 N  N   . MET A 1 561 ? -18.107 -52.928 -41.343 1.00 33.57  ? 824  MET A N   1 
ATOM   4174 C  CA  . MET A 1 561 ? -18.452 -54.375 -41.557 1.00 32.61  ? 824  MET A CA  1 
ATOM   4175 C  C   . MET A 1 561 ? -19.274 -54.455 -42.863 1.00 33.90  ? 824  MET A C   1 
ATOM   4176 O  O   . MET A 1 561 ? -20.432 -54.004 -42.905 1.00 34.73  ? 824  MET A O   1 
ATOM   4177 C  CB  . MET A 1 561 ? -19.267 -54.885 -40.350 1.00 34.37  ? 824  MET A CB  1 
ATOM   4178 C  CG  . MET A 1 561 ? -19.550 -56.414 -40.244 1.00 36.66  ? 824  MET A CG  1 
ATOM   4179 S  SD  . MET A 1 561 ? -18.033 -57.310 -40.159 1.00 52.75  ? 824  MET A SD  1 
ATOM   4180 C  CE  . MET A 1 561 ? -17.704 -57.182 -38.395 1.00 50.21  ? 824  MET A CE  1 
ATOM   4181 N  N   . GLU A 1 562 ? -18.682 -54.906 -43.957 1.00 38.02  ? 825  GLU A N   1 
ATOM   4182 C  CA  . GLU A 1 562 ? -19.380 -54.891 -45.274 1.00 45.61  ? 825  GLU A CA  1 
ATOM   4183 C  C   . GLU A 1 562 ? -20.407 -56.047 -45.322 1.00 39.20  ? 825  GLU A C   1 
ATOM   4184 O  O   . GLU A 1 562 ? -21.537 -55.789 -45.710 1.00 41.94  ? 825  GLU A O   1 
ATOM   4185 C  CB  . GLU A 1 562 ? -18.352 -54.920 -46.409 1.00 51.23  ? 825  GLU A CB  1 
ATOM   4186 C  CG  . GLU A 1 562 ? -18.945 -55.161 -47.783 1.00 64.33  ? 825  GLU A CG  1 
ATOM   4187 C  CD  . GLU A 1 562 ? -17.950 -55.102 -48.939 1.00 77.66  ? 825  GLU A CD  1 
ATOM   4188 O  OE1 . GLU A 1 562 ? -18.399 -54.808 -50.071 1.00 86.48  ? 825  GLU A OE1 1 
ATOM   4189 O  OE2 . GLU A 1 562 ? -16.726 -55.350 -48.715 1.00 90.41  ? 825  GLU A OE2 1 
ATOM   4190 N  N   . ASP A 1 563 ? -20.042 -57.255 -44.896 1.00 37.19  ? 826  ASP A N   1 
ATOM   4191 C  CA  . ASP A 1 563 ? -20.953 -58.429 -44.834 1.00 36.85  ? 826  ASP A CA  1 
ATOM   4192 C  C   . ASP A 1 563 ? -21.880 -58.289 -43.629 1.00 34.92  ? 826  ASP A C   1 
ATOM   4193 O  O   . ASP A 1 563 ? -21.362 -58.264 -42.494 1.00 37.68  ? 826  ASP A O   1 
ATOM   4194 C  CB  . ASP A 1 563 ? -20.123 -59.701 -44.697 1.00 37.11  ? 826  ASP A CB  1 
ATOM   4195 C  CG  . ASP A 1 563 ? -20.919 -60.986 -44.546 1.00 36.11  ? 826  ASP A CG  1 
ATOM   4196 O  OD1 . ASP A 1 563 ? -22.147 -60.916 -44.421 1.00 39.94  ? 826  ASP A OD1 1 
ATOM   4197 O  OD2 . ASP A 1 563 ? -20.285 -62.019 -44.416 1.00 41.42  ? 826  ASP A OD2 1 
ATOM   4198 N  N   . LYS A 1 564 ? -23.187 -58.287 -43.847 1.00 33.64  ? 827  LYS A N   1 
ATOM   4199 C  CA  . LYS A 1 564 ? -24.191 -57.991 -42.800 1.00 32.42  ? 827  LYS A CA  1 
ATOM   4200 C  C   . LYS A 1 564 ? -24.858 -59.294 -42.328 1.00 29.55  ? 827  LYS A C   1 
ATOM   4201 O  O   . LYS A 1 564 ? -25.948 -59.224 -41.707 1.00 32.57  ? 827  LYS A O   1 
ATOM   4202 C  CB  . LYS A 1 564 ? -25.215 -56.962 -43.280 1.00 33.48  ? 827  LYS A CB  1 
ATOM   4203 C  CG  . LYS A 1 564 ? -24.642 -55.610 -43.668 1.00 38.38  ? 827  LYS A CG  1 
ATOM   4204 C  CD  . LYS A 1 564 ? -23.920 -54.912 -42.551 1.00 32.23  ? 827  LYS A CD  1 
ATOM   4205 C  CE  . LYS A 1 564 ? -23.603 -53.485 -42.902 1.00 33.50  ? 827  LYS A CE  1 
ATOM   4206 N  NZ  . LYS A 1 564 ? -22.849 -52.855 -41.789 1.00 34.98  ? 827  LYS A NZ  1 
ATOM   4207 N  N   . THR A 1 565 ? -24.229 -60.442 -42.535 1.00 30.74  ? 828  THR A N   1 
ATOM   4208 C  CA  . THR A 1 565 ? -24.824 -61.736 -42.095 1.00 31.59  ? 828  THR A CA  1 
ATOM   4209 C  C   . THR A 1 565 ? -24.919 -61.730 -40.577 1.00 34.81  ? 828  THR A C   1 
ATOM   4210 O  O   . THR A 1 565 ? -23.879 -61.609 -39.915 1.00 33.31  ? 828  THR A O   1 
ATOM   4211 C  CB  . THR A 1 565 ? -23.962 -62.917 -42.526 1.00 36.69  ? 828  THR A CB  1 
ATOM   4212 O  OG1 . THR A 1 565 ? -23.714 -62.779 -43.918 1.00 38.08  ? 828  THR A OG1 1 
ATOM   4213 C  CG2 . THR A 1 565 ? -24.568 -64.266 -42.233 1.00 39.45  ? 828  THR A CG2 1 
ATOM   4214 N  N   . PRO A 1 566 ? -26.135 -61.880 -39.991 1.00 40.19  ? 829  PRO A N   1 
ATOM   4215 C  CA  . PRO A 1 566 ? -26.294 -61.881 -38.540 1.00 39.84  ? 829  PRO A CA  1 
ATOM   4216 C  C   . PRO A 1 566 ? -25.570 -63.072 -37.919 1.00 39.59  ? 829  PRO A C   1 
ATOM   4217 O  O   . PRO A 1 566 ? -25.362 -64.089 -38.538 1.00 34.12  ? 829  PRO A O   1 
ATOM   4218 C  CB  . PRO A 1 566 ? -27.808 -61.982 -38.316 1.00 42.03  ? 829  PRO A CB  1 
ATOM   4219 C  CG  . PRO A 1 566 ? -28.429 -61.632 -39.669 1.00 40.86  ? 829  PRO A CG  1 
ATOM   4220 C  CD  . PRO A 1 566 ? -27.420 -62.089 -40.682 1.00 41.39  ? 829  PRO A CD  1 
ATOM   4221 N  N   . VAL A 1 567 ? -25.143 -62.894 -36.686 1.00 36.26  ? 830  VAL A N   1 
ATOM   4222 C  CA  . VAL A 1 567 ? -24.552 -63.988 -35.888 1.00 36.29  ? 830  VAL A CA  1 
ATOM   4223 C  C   . VAL A 1 567 ? -25.733 -64.679 -35.176 1.00 34.51  ? 830  VAL A C   1 
ATOM   4224 O  O   . VAL A 1 567 ? -26.615 -63.960 -34.631 1.00 33.80  ? 830  VAL A O   1 
ATOM   4225 C  CB  . VAL A 1 567 ? -23.539 -63.305 -34.952 1.00 41.22  ? 830  VAL A CB  1 
ATOM   4226 C  CG1 . VAL A 1 567 ? -23.432 -63.991 -33.641 1.00 42.99  ? 830  VAL A CG1 1 
ATOM   4227 C  CG2 . VAL A 1 567 ? -22.191 -63.103 -35.620 1.00 42.06  ? 830  VAL A CG2 1 
ATOM   4228 N  N   . GLU A 1 568 ? -25.760 -66.006 -35.112 1.00 37.23  ? 831  GLU A N   1 
ATOM   4229 C  CA  . GLU A 1 568 ? -26.966 -66.756 -34.638 1.00 40.28  ? 831  GLU A CA  1 
ATOM   4230 C  C   . GLU A 1 568 ? -26.821 -67.133 -33.167 1.00 40.04  ? 831  GLU A C   1 
ATOM   4231 O  O   . GLU A 1 568 ? -27.837 -67.512 -32.559 1.00 36.84  ? 831  GLU A O   1 
ATOM   4232 C  CB  . GLU A 1 568 ? -27.145 -68.057 -35.439 1.00 46.10  ? 831  GLU A CB  1 
ATOM   4233 C  CG  . GLU A 1 568 ? -27.405 -67.849 -36.930 1.00 49.58  ? 831  GLU A CG  1 
ATOM   4234 C  CD  . GLU A 1 568 ? -28.742 -67.198 -37.246 1.00 52.43  ? 831  GLU A CD  1 
ATOM   4235 O  OE1 . GLU A 1 568 ? -29.704 -67.423 -36.490 1.00 54.87  ? 831  GLU A OE1 1 
ATOM   4236 O  OE2 . GLU A 1 568 ? -28.816 -66.459 -38.236 1.00 61.10  ? 831  GLU A OE2 1 
ATOM   4237 N  N   . SER A 1 569 ? -25.600 -67.129 -32.615 1.00 32.83  ? 832  SER A N   1 
ATOM   4238 C  CA  . SER A 1 569 ? -25.370 -67.531 -31.204 1.00 27.43  ? 832  SER A CA  1 
ATOM   4239 C  C   . SER A 1 569 ? -24.090 -66.890 -30.675 1.00 31.35  ? 832  SER A C   1 
ATOM   4240 O  O   . SER A 1 569 ? -23.206 -66.462 -31.475 1.00 31.11  ? 832  SER A O   1 
ATOM   4241 C  CB  . SER A 1 569 ? -25.303 -69.007 -31.065 1.00 35.04  ? 832  SER A CB  1 
ATOM   4242 O  OG  . SER A 1 569 ? -24.031 -69.511 -31.424 1.00 33.98  ? 832  SER A OG  1 
ATOM   4243 N  N   . TRP A 1 570 ? -24.017 -66.804 -29.366 1.00 28.01  ? 833  TRP A N   1 
ATOM   4244 C  CA  . TRP A 1 570 ? -22.842 -66.232 -28.673 1.00 32.36  ? 833  TRP A CA  1 
ATOM   4245 C  C   . TRP A 1 570 ? -21.583 -67.055 -29.012 1.00 33.24  ? 833  TRP A C   1 
ATOM   4246 O  O   . TRP A 1 570 ? -20.508 -66.498 -29.075 1.00 30.65  ? 833  TRP A O   1 
ATOM   4247 C  CB  . TRP A 1 570 ? -23.155 -66.149 -27.162 1.00 29.12  ? 833  TRP A CB  1 
ATOM   4248 C  CG  . TRP A 1 570 ? -23.991 -64.973 -26.808 1.00 29.10  ? 833  TRP A CG  1 
ATOM   4249 C  CD1 . TRP A 1 570 ? -25.337 -64.984 -26.585 1.00 29.28  ? 833  TRP A CD1 1 
ATOM   4250 C  CD2 . TRP A 1 570 ? -23.565 -63.593 -26.695 1.00 28.48  ? 833  TRP A CD2 1 
ATOM   4251 N  NE1 . TRP A 1 570 ? -25.764 -63.718 -26.323 1.00 32.47  ? 833  TRP A NE1 1 
ATOM   4252 C  CE2 . TRP A 1 570 ? -24.707 -62.846 -26.371 1.00 26.83  ? 833  TRP A CE2 1 
ATOM   4253 C  CE3 . TRP A 1 570 ? -22.335 -62.915 -26.796 1.00 30.10  ? 833  TRP A CE3 1 
ATOM   4254 C  CZ2 . TRP A 1 570 ? -24.656 -61.473 -26.114 1.00 30.95  ? 833  TRP A CZ2 1 
ATOM   4255 C  CZ3 . TRP A 1 570 ? -22.278 -61.559 -26.559 1.00 26.16  ? 833  TRP A CZ3 1 
ATOM   4256 C  CH2 . TRP A 1 570 ? -23.440 -60.841 -26.261 1.00 29.76  ? 833  TRP A CH2 1 
ATOM   4257 N  N   . GLU A 1 571 ? -21.685 -68.331 -29.353 1.00 32.71  ? 834  GLU A N   1 
ATOM   4258 C  CA  . GLU A 1 571 ? -20.474 -69.159 -29.647 1.00 40.11  ? 834  GLU A CA  1 
ATOM   4259 C  C   . GLU A 1 571 ? -19.802 -68.723 -30.952 1.00 34.44  ? 834  GLU A C   1 
ATOM   4260 O  O   . GLU A 1 571 ? -18.599 -68.941 -31.075 1.00 39.15  ? 834  GLU A O   1 
ATOM   4261 C  CB  . GLU A 1 571 ? -20.840 -70.647 -29.584 1.00 52.21  ? 834  GLU A CB  1 
ATOM   4262 C  CG  . GLU A 1 571 ? -21.101 -71.063 -28.136 1.00 73.53  ? 834  GLU A CG  1 
ATOM   4263 C  CD  . GLU A 1 571 ? -21.738 -72.423 -27.862 1.00 93.85  ? 834  GLU A CD  1 
ATOM   4264 O  OE1 . GLU A 1 571 ? -21.120 -73.450 -28.230 1.00 102.38 ? 834  GLU A OE1 1 
ATOM   4265 O  OE2 . GLU A 1 571 ? -22.840 -72.462 -27.235 1.00 111.85 ? 834  GLU A OE2 1 
ATOM   4266 N  N   . GLU A 1 572 ? -20.498 -68.077 -31.865 1.00 33.73  ? 835  GLU A N   1 
ATOM   4267 C  CA  . GLU A 1 572 ? -19.863 -67.461 -33.065 1.00 37.00  ? 835  GLU A CA  1 
ATOM   4268 C  C   . GLU A 1 572 ? -19.002 -66.243 -32.671 1.00 32.58  ? 835  GLU A C   1 
ATOM   4269 O  O   . GLU A 1 572 ? -18.332 -65.670 -33.566 1.00 33.07  ? 835  GLU A O   1 
ATOM   4270 C  CB  . GLU A 1 572 ? -20.883 -66.902 -34.071 1.00 37.24  ? 835  GLU A CB  1 
ATOM   4271 C  CG  . GLU A 1 572 ? -21.469 -67.924 -35.025 1.00 48.72  ? 835  GLU A CG  1 
ATOM   4272 C  CD  . GLU A 1 572 ? -22.576 -67.373 -35.943 1.00 47.02  ? 835  GLU A CD  1 
ATOM   4273 O  OE1 . GLU A 1 572 ? -22.275 -66.588 -36.863 1.00 47.98  ? 835  GLU A OE1 1 
ATOM   4274 O  OE2 . GLU A 1 572 ? -23.742 -67.727 -35.739 1.00 46.49  ? 835  GLU A OE2 1 
ATOM   4275 N  N   . ILE A 1 573 ? -19.155 -65.726 -31.453 1.00 30.07  ? 836  ILE A N   1 
ATOM   4276 C  CA  . ILE A 1 573 ? -18.558 -64.402 -31.100 1.00 30.21  ? 836  ILE A CA  1 
ATOM   4277 C  C   . ILE A 1 573 ? -17.239 -64.709 -30.388 1.00 29.22  ? 836  ILE A C   1 
ATOM   4278 O  O   . ILE A 1 573 ? -17.228 -65.389 -29.359 1.00 25.86  ? 836  ILE A O   1 
ATOM   4279 C  CB  . ILE A 1 573 ? -19.523 -63.548 -30.275 1.00 28.45  ? 836  ILE A CB  1 
ATOM   4280 C  CG1 . ILE A 1 573 ? -20.769 -63.177 -31.065 1.00 26.79  ? 836  ILE A CG1 1 
ATOM   4281 C  CG2 . ILE A 1 573 ? -18.805 -62.307 -29.764 1.00 32.06  ? 836  ILE A CG2 1 
ATOM   4282 C  CD1 . ILE A 1 573 ? -21.879 -62.560 -30.231 1.00 27.48  ? 836  ILE A CD1 1 
ATOM   4283 N  N   . PRO A 1 574 ? -16.083 -64.272 -30.931 1.00 29.04  ? 837  PRO A N   1 
ATOM   4284 C  CA  . PRO A 1 574 ? -14.781 -64.717 -30.416 1.00 26.89  ? 837  PRO A CA  1 
ATOM   4285 C  C   . PRO A 1 574 ? -14.296 -64.040 -29.124 1.00 24.82  ? 837  PRO A C   1 
ATOM   4286 O  O   . PRO A 1 574 ? -14.814 -62.994 -28.711 1.00 22.77  ? 837  PRO A O   1 
ATOM   4287 C  CB  . PRO A 1 574 ? -13.826 -64.291 -31.549 1.00 30.02  ? 837  PRO A CB  1 
ATOM   4288 C  CG  . PRO A 1 574 ? -14.458 -63.018 -32.061 1.00 31.89  ? 837  PRO A CG  1 
ATOM   4289 C  CD  . PRO A 1 574 ? -15.960 -63.233 -31.958 1.00 30.51  ? 837  PRO A CD  1 
ATOM   4290 N  N   . TYR A 1 575 ? -13.284 -64.643 -28.516 1.00 25.49  ? 838  TYR A N   1 
ATOM   4291 C  CA  . TYR A 1 575 ? -12.482 -64.056 -27.426 1.00 24.38  ? 838  TYR A CA  1 
ATOM   4292 C  C   . TYR A 1 575 ? -11.110 -63.574 -27.940 1.00 28.77  ? 838  TYR A C   1 
ATOM   4293 O  O   . TYR A 1 575 ? -10.657 -64.040 -28.987 1.00 24.16  ? 838  TYR A O   1 
ATOM   4294 C  CB  . TYR A 1 575 ? -12.255 -65.131 -26.382 1.00 27.12  ? 838  TYR A CB  1 
ATOM   4295 C  CG  . TYR A 1 575 ? -13.492 -65.646 -25.686 1.00 26.79  ? 838  TYR A CG  1 
ATOM   4296 C  CD1 . TYR A 1 575 ? -14.161 -64.870 -24.753 1.00 23.75  ? 838  TYR A CD1 1 
ATOM   4297 C  CD2 . TYR A 1 575 ? -13.935 -66.944 -25.879 1.00 32.11  ? 838  TYR A CD2 1 
ATOM   4298 C  CE1 . TYR A 1 575 ? -15.264 -65.353 -24.069 1.00 26.61  ? 838  TYR A CE1 1 
ATOM   4299 C  CE2 . TYR A 1 575 ? -15.023 -67.448 -25.188 1.00 33.29  ? 838  TYR A CE2 1 
ATOM   4300 C  CZ  . TYR A 1 575 ? -15.706 -66.634 -24.295 1.00 30.69  ? 838  TYR A CZ  1 
ATOM   4301 O  OH  . TYR A 1 575 ? -16.799 -67.070 -23.610 1.00 32.17  ? 838  TYR A OH  1 
ATOM   4302 N  N   . LEU A 1 576 ? -10.405 -62.751 -27.153 1.00 22.77  ? 839  LEU A N   1 
ATOM   4303 C  CA  . LEU A 1 576 ? -8.955  -62.506 -27.305 1.00 23.92  ? 839  LEU A CA  1 
ATOM   4304 C  C   . LEU A 1 576 ? -8.256  -63.866 -27.238 1.00 23.94  ? 839  LEU A C   1 
ATOM   4305 O  O   . LEU A 1 576 ? -8.842  -64.787 -26.638 1.00 22.18  ? 839  LEU A O   1 
ATOM   4306 C  CB  . LEU A 1 576 ? -8.449  -61.592 -26.182 1.00 24.18  ? 839  LEU A CB  1 
ATOM   4307 C  CG  . LEU A 1 576 ? -9.073  -60.205 -26.063 1.00 22.38  ? 839  LEU A CG  1 
ATOM   4308 C  CD1 . LEU A 1 576 ? -8.364  -59.360 -25.009 1.00 23.01  ? 839  LEU A CD1 1 
ATOM   4309 C  CD2 . LEU A 1 576 ? -9.037  -59.465 -27.379 1.00 23.72  ? 839  LEU A CD2 1 
ATOM   4310 N  N   . GLY A 1 577 ? -7.035  -63.976 -27.754 1.00 26.44  ? 840  GLY A N   1 
ATOM   4311 C  CA  . GLY A 1 577 ? -6.146  -65.114 -27.411 1.00 25.60  ? 840  GLY A CA  1 
ATOM   4312 C  C   . GLY A 1 577 ? -6.056  -65.274 -25.901 1.00 22.82  ? 840  GLY A C   1 
ATOM   4313 O  O   . GLY A 1 577 ? -6.128  -64.280 -25.156 1.00 22.48  ? 840  GLY A O   1 
ATOM   4314 N  N   . LYS A 1 578 ? -5.890  -66.526 -25.464 0.48 23.36  ? 841  LYS A N   1 
ATOM   4315 C  CA  . LYS A 1 578 ? -5.776  -66.927 -24.034 0.48 24.19  ? 841  LYS A CA  1 
ATOM   4316 C  C   . LYS A 1 578 ? -4.635  -66.154 -23.363 0.48 22.09  ? 841  LYS A C   1 
ATOM   4317 O  O   . LYS A 1 578 ? -4.825  -65.689 -22.240 0.48 20.27  ? 841  LYS A O   1 
ATOM   4318 C  CB  . LYS A 1 578 ? -5.532  -68.433 -23.907 0.48 26.12  ? 841  LYS A CB  1 
ATOM   4319 C  CG  . LYS A 1 578 ? -6.622  -69.333 -24.482 0.48 27.03  ? 841  LYS A CG  1 
ATOM   4320 C  CD  . LYS A 1 578 ? -6.360  -70.836 -24.304 0.48 28.26  ? 841  LYS A CD  1 
ATOM   4321 C  CE  . LYS A 1 578 ? -5.294  -71.419 -25.205 0.48 25.72  ? 841  LYS A CE  1 
ATOM   4322 N  NZ  . LYS A 1 578 ? -5.631  -71.239 -26.630 0.48 25.38  ? 841  LYS A NZ  1 
ATOM   4323 N  N   . ARG A 1 579 ? -3.494  -65.987 -24.025 0.48 21.31  ? 842  ARG A N   1 
ATOM   4324 C  CA  . ARG A 1 579 ? -2.334  -65.310 -23.396 0.48 21.55  ? 842  ARG A CA  1 
ATOM   4325 C  C   . ARG A 1 579 ? -2.672  -63.813 -23.256 0.48 20.72  ? 842  ARG A C   1 
ATOM   4326 O  O   . ARG A 1 579 ? -2.439  -63.248 -22.157 0.48 21.44  ? 842  ARG A O   1 
ATOM   4327 C  CB  . ARG A 1 579 ? -1.040  -65.574 -24.176 0.48 20.85  ? 842  ARG A CB  1 
ATOM   4328 C  CG  . ARG A 1 579 ? 0.193   -65.039 -23.463 0.48 21.69  ? 842  ARG A CG  1 
ATOM   4329 C  CD  . ARG A 1 579 ? 1.487   -65.268 -24.226 0.48 22.79  ? 842  ARG A CD  1 
ATOM   4330 N  NE  . ARG A 1 579 ? 1.758   -66.698 -24.361 0.48 23.56  ? 842  ARG A NE  1 
ATOM   4331 C  CZ  . ARG A 1 579 ? 2.314   -67.469 -23.446 0.48 21.94  ? 842  ARG A CZ  1 
ATOM   4332 N  NH1 . ARG A 1 579 ? 2.509   -68.748 -23.716 0.48 24.84  ? 842  ARG A NH1 1 
ATOM   4333 N  NH2 . ARG A 1 579 ? 2.671   -66.988 -22.272 0.48 23.20  ? 842  ARG A NH2 1 
ATOM   4334 N  N   . GLU A 1 580 ? -3.195  -63.211 -24.326 0.48 20.99  ? 843  GLU A N   1 
ATOM   4335 C  CA  . GLU A 1 580 ? -3.567  -61.760 -24.420 0.48 22.40  ? 843  GLU A CA  1 
ATOM   4336 C  C   . GLU A 1 580 ? -4.672  -61.415 -23.400 0.48 21.08  ? 843  GLU A C   1 
ATOM   4337 O  O   . GLU A 1 580 ? -4.713  -60.269 -22.928 0.48 21.84  ? 843  GLU A O   1 
ATOM   4338 C  CB  . GLU A 1 580 ? -4.073  -61.411 -25.822 0.48 23.04  ? 843  GLU A CB  1 
ATOM   4339 C  CG  . GLU A 1 580 ? -3.095  -61.687 -26.947 0.48 24.37  ? 843  GLU A CG  1 
ATOM   4340 C  CD  . GLU A 1 580 ? -3.688  -61.466 -28.335 0.48 26.96  ? 843  GLU A CD  1 
ATOM   4341 O  OE1 . GLU A 1 580 ? -4.729  -62.101 -28.651 0.48 28.53  ? 843  GLU A OE1 1 
ATOM   4342 O  OE2 . GLU A 1 580 ? -3.132  -60.640 -29.094 0.48 28.66  ? 843  GLU A OE2 1 
ATOM   4343 N  N   . ASP A 1 581 ? -5.555  -62.368 -23.096 1.00 21.09  ? 844  ASP A N   1 
ATOM   4344 C  CA  . ASP A 1 581 ? -6.610  -62.200 -22.055 1.00 21.22  ? 844  ASP A CA  1 
ATOM   4345 C  C   . ASP A 1 581 ? -5.912  -62.102 -20.699 1.00 21.25  ? 844  ASP A C   1 
ATOM   4346 O  O   . ASP A 1 581 ? -6.234  -61.197 -19.930 1.00 20.01  ? 844  ASP A O   1 
ATOM   4347 C  CB  . ASP A 1 581 ? -7.643  -63.320 -22.170 1.00 21.71  ? 844  ASP A CB  1 
ATOM   4348 C  CG  . ASP A 1 581 ? -9.069  -63.016 -21.682 1.00 22.08  ? 844  ASP A CG  1 
ATOM   4349 O  OD1 . ASP A 1 581 ? -9.295  -61.964 -21.064 1.00 19.96  ? 844  ASP A OD1 1 
ATOM   4350 O  OD2 . ASP A 1 581 ? -9.956  -63.861 -21.941 1.00 20.27  ? 844  ASP A OD2 1 
ATOM   4351 N  N   . GLN A 1 582 ? -4.929  -62.970 -20.426 0.48 19.44  ? 845  GLN A N   1 
ATOM   4352 C  CA  . GLN A 1 582 ? -4.116  -62.899 -19.179 0.48 19.59  ? 845  GLN A CA  1 
ATOM   4353 C  C   . GLN A 1 582 ? -3.405  -61.541 -19.133 0.48 19.66  ? 845  GLN A C   1 
ATOM   4354 O  O   . GLN A 1 582 ? -3.555  -60.826 -18.131 0.48 19.14  ? 845  GLN A O   1 
ATOM   4355 C  CB  . GLN A 1 582 ? -3.112  -64.061 -19.084 0.48 20.26  ? 845  GLN A CB  1 
ATOM   4356 C  CG  . GLN A 1 582 ? -3.765  -65.413 -18.893 0.48 20.14  ? 845  GLN A CG  1 
ATOM   4357 C  CD  . GLN A 1 582 ? -2.801  -66.571 -19.048 0.48 20.31  ? 845  GLN A CD  1 
ATOM   4358 O  OE1 . GLN A 1 582 ? -1.718  -66.419 -19.612 0.48 18.16  ? 845  GLN A OE1 1 
ATOM   4359 N  NE2 . GLN A 1 582 ? -3.226  -67.750 -18.586 0.48 19.37  ? 845  GLN A NE2 1 
ATOM   4360 N  N   . TRP A 1 583 ? -2.656  -61.189 -20.184 0.48 20.08  ? 846  TRP A N   1 
ATOM   4361 C  CA  . TRP A 1 583 ? -1.915  -59.897 -20.263 0.48 19.28  ? 846  TRP A CA  1 
ATOM   4362 C  C   . TRP A 1 583 ? -2.834  -58.746 -19.819 0.48 20.88  ? 846  TRP A C   1 
ATOM   4363 O  O   . TRP A 1 583 ? -2.360  -57.850 -19.101 0.48 19.29  ? 846  TRP A O   1 
ATOM   4364 C  CB  . TRP A 1 583 ? -1.379  -59.655 -21.673 0.48 20.06  ? 846  TRP A CB  1 
ATOM   4365 C  CG  . TRP A 1 583 ? -0.244  -60.547 -22.095 0.48 20.20  ? 846  TRP A CG  1 
ATOM   4366 C  CD1 . TRP A 1 583 ? 0.495   -61.400 -21.322 0.48 20.41  ? 846  TRP A CD1 1 
ATOM   4367 C  CD2 . TRP A 1 583 ? 0.303   -60.639 -23.420 0.48 19.75  ? 846  TRP A CD2 1 
ATOM   4368 N  NE1 . TRP A 1 583 ? 1.453   -62.028 -22.083 0.48 21.42  ? 846  TRP A NE1 1 
ATOM   4369 C  CE2 . TRP A 1 583 ? 1.359   -61.575 -23.371 0.48 21.26  ? 846  TRP A CE2 1 
ATOM   4370 C  CE3 . TRP A 1 583 ? 0.002   -60.021 -24.638 0.48 20.94  ? 846  TRP A CE3 1 
ATOM   4371 C  CZ2 . TRP A 1 583 ? 2.110   -61.897 -24.499 0.48 22.37  ? 846  TRP A CZ2 1 
ATOM   4372 C  CZ3 . TRP A 1 583 ? 0.741   -60.346 -25.754 0.48 21.34  ? 846  TRP A CZ3 1 
ATOM   4373 C  CH2 . TRP A 1 583 ? 1.782   -61.271 -25.679 0.48 21.28  ? 846  TRP A CH2 1 
ATOM   4374 N  N   . CYS A 1 584 ? -4.118  -58.780 -20.203 0.48 19.96  ? 847  CYS A N   1 
ATOM   4375 C  CA  . CYS A 1 584 ? -5.089  -57.700 -19.902 0.48 20.10  ? 847  CYS A CA  1 
ATOM   4376 C  C   . CYS A 1 584 ? -5.842  -57.977 -18.588 0.48 21.09  ? 847  CYS A C   1 
ATOM   4377 O  O   . CYS A 1 584 ? -6.868  -57.317 -18.373 0.48 21.52  ? 847  CYS A O   1 
ATOM   4378 C  CB  . CYS A 1 584 ? -6.014  -57.497 -21.091 0.48 20.62  ? 847  CYS A CB  1 
ATOM   4379 S  SG  . CYS A 1 584 ? -5.127  -56.869 -22.542 0.48 21.57  ? 847  CYS A SG  1 
ATOM   4380 N  N   . GLY A 1 585 ? -5.355  -58.909 -17.748 1.00 22.62  ? 848  GLY A N   1 
ATOM   4381 C  CA  . GLY A 1 585 ? -5.784  -59.068 -16.332 1.00 22.34  ? 848  GLY A CA  1 
ATOM   4382 C  C   . GLY A 1 585 ? -6.646  -60.295 -16.070 1.00 22.36  ? 848  GLY A C   1 
ATOM   4383 O  O   . GLY A 1 585 ? -7.130  -60.402 -14.971 1.00 25.14  ? 848  GLY A O   1 
ATOM   4384 N  N   . SER A 1 586 ? -6.913  -61.155 -17.056 1.00 22.09  ? 849  SER A N   1 
ATOM   4385 C  CA  . SER A 1 586 ? -7.765  -62.357 -16.860 1.00 23.89  ? 849  SER A CA  1 
ATOM   4386 C  C   . SER A 1 586 ? -7.167  -63.263 -15.774 1.00 25.41  ? 849  SER A C   1 
ATOM   4387 O  O   . SER A 1 586 ? -5.928  -63.390 -15.681 1.00 22.20  ? 849  SER A O   1 
ATOM   4388 C  CB  . SER A 1 586 ? -7.878  -63.167 -18.099 1.00 20.61  ? 849  SER A CB  1 
ATOM   4389 O  OG  . SER A 1 586 ? -8.782  -64.256 -17.855 1.00 21.15  ? 849  SER A OG  1 
ATOM   4390 N  N   . LEU A 1 587 ? -8.041  -63.963 -15.057 0.48 23.46  ? 850  LEU A N   1 
ATOM   4391 C  CA  . LEU A 1 587 ? -7.660  -65.015 -14.084 0.48 23.73  ? 850  LEU A CA  1 
ATOM   4392 C  C   . LEU A 1 587 ? -7.711  -66.400 -14.735 0.48 23.58  ? 850  LEU A C   1 
ATOM   4393 O  O   . LEU A 1 587 ? -7.411  -67.366 -14.015 0.48 23.50  ? 850  LEU A O   1 
ATOM   4394 C  CB  . LEU A 1 587 ? -8.592  -64.952 -12.868 0.48 24.61  ? 850  LEU A CB  1 
ATOM   4395 C  CG  . LEU A 1 587 ? -8.514  -63.692 -12.009 0.48 24.83  ? 850  LEU A CG  1 
ATOM   4396 C  CD1 . LEU A 1 587 ? -9.132  -63.946 -10.643 0.48 25.62  ? 850  LEU A CD1 1 
ATOM   4397 C  CD2 . LEU A 1 587 ? -7.082  -63.185 -11.860 0.48 25.91  ? 850  LEU A CD2 1 
ATOM   4398 N  N   . ILE A 1 588 ? -8.020  -66.532 -16.037 0.48 24.21  ? 851  ILE A N   1 
ATOM   4399 C  CA  . ILE A 1 588 ? -7.979  -67.886 -16.675 0.48 26.07  ? 851  ILE A CA  1 
ATOM   4400 C  C   . ILE A 1 588 ? -6.644  -68.530 -16.276 0.48 27.57  ? 851  ILE A C   1 
ATOM   4401 O  O   . ILE A 1 588 ? -5.594  -67.868 -16.431 0.48 25.37  ? 851  ILE A O   1 
ATOM   4402 C  CB  . ILE A 1 588 ? -8.176  -67.899 -18.208 0.48 26.54  ? 851  ILE A CB  1 
ATOM   4403 C  CG1 . ILE A 1 588 ? -7.210  -66.965 -18.945 0.48 26.94  ? 851  ILE A CG1 1 
ATOM   4404 C  CG2 . ILE A 1 588 ? -9.625  -67.604 -18.557 0.48 26.28  ? 851  ILE A CG2 1 
ATOM   4405 C  CD1 . ILE A 1 588 ? -7.404  -66.933 -20.445 0.48 26.54  ? 851  ILE A CD1 1 
ATOM   4406 N  N   . GLY A 1 589 ? -6.700  -69.766 -15.772 1.00 30.13  ? 852  GLY A N   1 
ATOM   4407 C  CA  . GLY A 1 589 ? -5.501  -70.510 -15.358 1.00 30.98  ? 852  GLY A CA  1 
ATOM   4408 C  C   . GLY A 1 589 ? -5.345  -70.623 -13.844 1.00 33.31  ? 852  GLY A C   1 
ATOM   4409 O  O   . GLY A 1 589 ? -4.652  -71.512 -13.420 1.00 37.54  ? 852  GLY A O   1 
ATOM   4410 N  N   . LEU A 1 590 ? -6.006  -69.772 -13.055 0.48 30.96  ? 853  LEU A N   1 
ATOM   4411 C  CA  . LEU A 1 590 ? -5.905  -69.813 -11.568 0.48 31.81  ? 853  LEU A CA  1 
ATOM   4412 C  C   . LEU A 1 590 ? -6.988  -70.727 -10.981 0.48 33.12  ? 853  LEU A C   1 
ATOM   4413 O  O   . LEU A 1 590 ? -8.172  -70.651 -11.411 0.48 27.27  ? 853  LEU A O   1 
ATOM   4414 C  CB  . LEU A 1 590 ? -6.023  -68.408 -10.976 0.48 32.82  ? 853  LEU A CB  1 
ATOM   4415 C  CG  . LEU A 1 590 ? -4.948  -67.406 -11.395 0.48 36.75  ? 853  LEU A CG  1 
ATOM   4416 C  CD1 . LEU A 1 590 ? -5.147  -66.089 -10.667 0.48 38.35  ? 853  LEU A CD1 1 
ATOM   4417 C  CD2 . LEU A 1 590 ? -3.550  -67.949 -11.137 0.48 37.31  ? 853  LEU A CD2 1 
ATOM   4418 N  N   . THR A 1 591 ? -6.601  -71.510 -9.971  1.00 33.18  ? 854  THR A N   1 
ATOM   4419 C  CA  . THR A 1 591 ? -7.506  -72.415 -9.238  1.00 36.38  ? 854  THR A CA  1 
ATOM   4420 C  C   . THR A 1 591 ? -8.731  -71.659 -8.729  1.00 29.41  ? 854  THR A C   1 
ATOM   4421 O  O   . THR A 1 591 ? -9.812  -72.215 -8.829  1.00 32.37  ? 854  THR A O   1 
ATOM   4422 C  CB  . THR A 1 591 ? -6.696  -73.020 -8.075  1.00 40.72  ? 854  THR A CB  1 
ATOM   4423 O  OG1 . THR A 1 591 ? -5.693  -73.759 -8.746  1.00 43.32  ? 854  THR A OG1 1 
ATOM   4424 C  CG2 . THR A 1 591 ? -7.474  -73.902 -7.136  1.00 44.66  ? 854  THR A CG2 1 
ATOM   4425 N  N   . SER A 1 592 ? -8.586  -70.485 -8.125  1.00 28.07  ? 855  SER A N   1 
ATOM   4426 C  CA  . SER A 1 592 ? -9.738  -69.643 -7.682  1.00 27.72  ? 855  SER A CA  1 
ATOM   4427 C  C   . SER A 1 592 ? -10.770 -69.485 -8.829  1.00 28.49  ? 855  SER A C   1 
ATOM   4428 O  O   . SER A 1 592 ? -11.992 -69.673 -8.588  1.00 28.53  ? 855  SER A O   1 
ATOM   4429 C  CB  . SER A 1 592 ? -9.309  -68.332 -7.081  1.00 29.40  ? 855  SER A CB  1 
ATOM   4430 O  OG  . SER A 1 592 ? -8.557  -67.502 -7.968  1.00 34.89  ? 855  SER A OG  1 
ATOM   4431 N  N   . ARG A 1 593 ? -10.304 -69.209 -10.038 1.00 27.73  ? 856  ARG A N   1 
ATOM   4432 C  CA  . ARG A 1 593 ? -11.156 -68.863 -11.186 1.00 27.65  ? 856  ARG A CA  1 
ATOM   4433 C  C   . ARG A 1 593 ? -11.848 -70.152 -11.623 1.00 28.19  ? 856  ARG A C   1 
ATOM   4434 O  O   . ARG A 1 593 ? -13.002 -70.086 -11.989 1.00 25.37  ? 856  ARG A O   1 
ATOM   4435 C  CB  . ARG A 1 593 ? -10.307 -68.230 -12.284 1.00 26.94  ? 856  ARG A CB  1 
ATOM   4436 C  CG  . ARG A 1 593 ? -11.061 -67.589 -13.439 1.00 27.59  ? 856  ARG A CG  1 
ATOM   4437 C  CD  . ARG A 1 593 ? -11.573 -68.565 -14.463 1.00 27.07  ? 856  ARG A CD  1 
ATOM   4438 N  NE  . ARG A 1 593 ? -12.083 -67.806 -15.591 1.00 25.51  ? 856  ARG A NE  1 
ATOM   4439 C  CZ  . ARG A 1 593 ? -12.857 -68.299 -16.555 1.00 29.41  ? 856  ARG A CZ  1 
ATOM   4440 N  NH1 . ARG A 1 593 ? -13.157 -69.588 -16.575 1.00 25.24  ? 856  ARG A NH1 1 
ATOM   4441 N  NH2 . ARG A 1 593 ? -13.321 -67.504 -17.517 1.00 26.31  ? 856  ARG A NH2 1 
ATOM   4442 N  N   . ALA A 1 594 ? -11.126 -71.257 -11.713 1.00 24.85  ? 857  ALA A N   1 
ATOM   4443 C  CA  . ALA A 1 594 ? -11.703 -72.550 -12.165 1.00 27.32  ? 857  ALA A CA  1 
ATOM   4444 C  C   . ALA A 1 594 ? -12.829 -72.995 -11.206 1.00 27.65  ? 857  ALA A C   1 
ATOM   4445 O  O   . ALA A 1 594 ? -13.859 -73.503 -11.681 1.00 28.54  ? 857  ALA A O   1 
ATOM   4446 C  CB  . ALA A 1 594 ? -10.624 -73.594 -12.301 1.00 30.52  ? 857  ALA A CB  1 
ATOM   4447 N  N   . THR A 1 595 ? -12.658 -72.821 -9.906  1.00 27.25  ? 858  THR A N   1 
ATOM   4448 C  CA  . THR A 1 595 ? -13.677 -73.215 -8.924  1.00 30.93  ? 858  THR A CA  1 
ATOM   4449 C  C   . THR A 1 595 ? -14.915 -72.322 -9.105  1.00 31.57  ? 858  THR A C   1 
ATOM   4450 O  O   . THR A 1 595 ? -16.054 -72.796 -9.009  1.00 28.00  ? 858  THR A O   1 
ATOM   4451 C  CB  . THR A 1 595 ? -13.130 -73.031 -7.507  1.00 36.72  ? 858  THR A CB  1 
ATOM   4452 O  OG1 . THR A 1 595 ? -11.992 -73.895 -7.407  1.00 40.13  ? 858  THR A OG1 1 
ATOM   4453 C  CG2 . THR A 1 595 ? -14.167 -73.373 -6.454  1.00 37.51  ? 858  THR A CG2 1 
ATOM   4454 N  N   . TRP A 1 596 ? -14.687 -71.025 -9.252  1.00 25.89  ? 859  TRP A N   1 
ATOM   4455 C  CA  . TRP A 1 596 ? -15.793 -70.049 -9.467  1.00 24.96  ? 859  TRP A CA  1 
ATOM   4456 C  C   . TRP A 1 596 ? -16.585 -70.457 -10.722 1.00 24.13  ? 859  TRP A C   1 
ATOM   4457 O  O   . TRP A 1 596 ? -17.828 -70.529 -10.646 1.00 26.88  ? 859  TRP A O   1 
ATOM   4458 C  CB  . TRP A 1 596 ? -15.166 -68.654 -9.558  1.00 25.94  ? 859  TRP A CB  1 
ATOM   4459 C  CG  . TRP A 1 596 ? -16.031 -67.569 -10.132 1.00 23.14  ? 859  TRP A CG  1 
ATOM   4460 C  CD1 . TRP A 1 596 ? -17.073 -66.980 -9.484  1.00 23.79  ? 859  TRP A CD1 1 
ATOM   4461 C  CD2 . TRP A 1 596 ? -15.882 -66.891 -11.388 1.00 23.79  ? 859  TRP A CD2 1 
ATOM   4462 N  NE1 . TRP A 1 596 ? -17.565 -65.967 -10.243 1.00 23.73  ? 859  TRP A NE1 1 
ATOM   4463 C  CE2 . TRP A 1 596 ? -16.905 -65.917 -11.433 1.00 23.50  ? 859  TRP A CE2 1 
ATOM   4464 C  CE3 . TRP A 1 596 ? -15.004 -66.997 -12.486 1.00 27.20  ? 859  TRP A CE3 1 
ATOM   4465 C  CZ2 . TRP A 1 596 ? -17.019 -64.990 -12.475 1.00 22.77  ? 859  TRP A CZ2 1 
ATOM   4466 C  CZ3 . TRP A 1 596 ? -15.130 -66.102 -13.539 1.00 26.95  ? 859  TRP A CZ3 1 
ATOM   4467 C  CH2 . TRP A 1 596 ? -16.132 -65.108 -13.516 1.00 25.72  ? 859  TRP A CH2 1 
ATOM   4468 N  N   . ALA A 1 597 ? -15.930 -70.662 -11.864 1.00 24.16  ? 860  ALA A N   1 
ATOM   4469 C  CA  . ALA A 1 597 ? -16.608 -71.026 -13.139 1.00 25.64  ? 860  ALA A CA  1 
ATOM   4470 C  C   . ALA A 1 597 ? -17.367 -72.351 -13.008 1.00 28.84  ? 860  ALA A C   1 
ATOM   4471 O  O   . ALA A 1 597 ? -18.538 -72.413 -13.389 1.00 28.43  ? 860  ALA A O   1 
ATOM   4472 C  CB  . ALA A 1 597 ? -15.615 -71.125 -14.274 1.00 23.51  ? 860  ALA A CB  1 
ATOM   4473 N  N   . LYS A 1 598 ? -16.717 -73.364 -12.427 1.00 31.83  ? 861  LYS A N   1 
ATOM   4474 C  CA  . LYS A 1 598 ? -17.342 -74.706 -12.261 1.00 33.15  ? 861  LYS A CA  1 
ATOM   4475 C  C   . LYS A 1 598 ? -18.585 -74.617 -11.384 1.00 29.04  ? 861  LYS A C   1 
ATOM   4476 O  O   . LYS A 1 598 ? -19.584 -75.259 -11.728 1.00 31.07  ? 861  LYS A O   1 
ATOM   4477 C  CB  . LYS A 1 598 ? -16.356 -75.690 -11.637 1.00 39.87  ? 861  LYS A CB  1 
ATOM   4478 C  CG  . LYS A 1 598 ? -16.833 -77.141 -11.543 1.00 46.56  ? 861  LYS A CG  1 
ATOM   4479 C  CD  . LYS A 1 598 ? -15.729 -78.113 -11.117 1.00 58.78  ? 861  LYS A CD  1 
ATOM   4480 C  CE  . LYS A 1 598 ? -15.781 -79.419 -11.897 1.00 73.00  ? 861  LYS A CE  1 
ATOM   4481 N  NZ  . LYS A 1 598 ? -17.147 -80.012 -11.887 1.00 68.79  ? 861  LYS A NZ  1 
ATOM   4482 N  N   . ASN A 1 599 ? -18.538 -73.849 -10.300 1.00 29.43  ? 862  ASN A N   1 
ATOM   4483 C  CA  . ASN A 1 599 ? -19.618 -73.769 -9.296  1.00 27.98  ? 862  ASN A CA  1 
ATOM   4484 C  C   . ASN A 1 599 ? -20.520 -72.545 -9.503  1.00 25.70  ? 862  ASN A C   1 
ATOM   4485 O  O   . ASN A 1 599 ? -21.214 -72.168 -8.525  1.00 27.58  ? 862  ASN A O   1 
ATOM   4486 C  CB  . ASN A 1 599 ? -19.031 -73.766 -7.881  1.00 31.04  ? 862  ASN A CB  1 
ATOM   4487 C  CG  . ASN A 1 599 ? -18.310 -75.053 -7.567  1.00 33.90  ? 862  ASN A CG  1 
ATOM   4488 O  OD1 . ASN A 1 599 ? -18.806 -76.117 -7.856  1.00 38.43  ? 862  ASN A OD1 1 
ATOM   4489 N  ND2 . ASN A 1 599 ? -17.153 -74.957 -6.988  1.00 42.94  ? 862  ASN A ND2 1 
ATOM   4490 N  N   . ILE A 1 600 ? -20.553 -71.942 -10.687 1.00 26.15  ? 863  ILE A N   1 
ATOM   4491 C  CA  . ILE A 1 600 ? -21.220 -70.610 -10.878 1.00 25.19  ? 863  ILE A CA  1 
ATOM   4492 C  C   . ILE A 1 600 ? -22.736 -70.699 -10.546 1.00 26.54  ? 863  ILE A C   1 
ATOM   4493 O  O   . ILE A 1 600 ? -23.296 -69.736 -10.038 1.00 23.07  ? 863  ILE A O   1 
ATOM   4494 C  CB  . ILE A 1 600 ? -20.929 -70.022 -12.264 1.00 23.13  ? 863  ILE A CB  1 
ATOM   4495 C  CG1 . ILE A 1 600 ? -21.256 -68.533 -12.358 1.00 28.29  ? 863  ILE A CG1 1 
ATOM   4496 C  CG2 . ILE A 1 600 ? -21.639 -70.786 -13.387 1.00 24.35  ? 863  ILE A CG2 1 
ATOM   4497 C  CD1 . ILE A 1 600 ? -20.406 -67.696 -11.529 1.00 25.54  ? 863  ILE A CD1 1 
ATOM   4498 N  N   A GLN A 1 601 ? -23.379 -71.844 -10.805 0.25 25.25  ? 864  GLN A N   1 
ATOM   4499 N  N   B GLN A 1 601 ? -23.373 -71.848 -10.796 0.25 25.75  ? 864  GLN A N   1 
ATOM   4500 C  CA  A GLN A 1 601 ? -24.835 -72.008 -10.540 0.25 26.44  ? 864  GLN A CA  1 
ATOM   4501 C  CA  B GLN A 1 601 ? -24.832 -72.014 -10.552 0.25 27.28  ? 864  GLN A CA  1 
ATOM   4502 C  C   A GLN A 1 601 ? -25.129 -71.870 -9.035  0.25 26.61  ? 864  GLN A C   1 
ATOM   4503 C  C   B GLN A 1 601 ? -25.138 -71.900 -9.043  0.25 27.12  ? 864  GLN A C   1 
ATOM   4504 O  O   A GLN A 1 601 ? -26.237 -71.376 -8.689  0.25 26.36  ? 864  GLN A O   1 
ATOM   4505 O  O   B GLN A 1 601 ? -26.259 -71.435 -8.699  0.25 26.80  ? 864  GLN A O   1 
ATOM   4506 C  CB  A GLN A 1 601 ? -25.354 -73.332 -11.093 0.25 26.57  ? 864  GLN A CB  1 
ATOM   4507 C  CB  B GLN A 1 601 ? -25.327 -73.314 -11.181 0.25 27.99  ? 864  GLN A CB  1 
ATOM   4508 C  CG  A GLN A 1 601 ? -25.327 -73.401 -12.611 0.25 26.92  ? 864  GLN A CG  1 
ATOM   4509 C  CG  B GLN A 1 601 ? -26.845 -73.420 -11.271 0.25 29.37  ? 864  GLN A CG  1 
ATOM   4510 C  CD  A GLN A 1 601 ? -26.285 -72.465 -13.309 0.25 28.20  ? 864  GLN A CD  1 
ATOM   4511 C  CD  B GLN A 1 601 ? -27.546 -72.203 -11.821 0.25 30.20  ? 864  GLN A CD  1 
ATOM   4512 O  OE1 A GLN A 1 601 ? -27.216 -71.925 -12.716 0.25 30.14  ? 864  GLN A OE1 1 
ATOM   4513 O  OE1 B GLN A 1 601 ? -27.387 -71.832 -12.983 0.25 30.89  ? 864  GLN A OE1 1 
ATOM   4514 N  NE2 A GLN A 1 601 ? -26.082 -72.303 -14.608 0.25 29.16  ? 864  GLN A NE2 1 
ATOM   4515 N  NE2 B GLN A 1 601 ? -28.370 -71.594 -10.985 0.25 30.43  ? 864  GLN A NE2 1 
ATOM   4516 N  N   . THR A 1 602 ? -24.194 -72.283 -8.175  1.00 25.75  ? 865  THR A N   1 
ATOM   4517 C  CA  . THR A 1 602 ? -24.325 -72.080 -6.697  1.00 29.04  ? 865  THR A CA  1 
ATOM   4518 C  C   . THR A 1 602 ? -24.308 -70.582 -6.349  1.00 27.95  ? 865  THR A C   1 
ATOM   4519 O  O   . THR A 1 602 ? -25.000 -70.166 -5.442  1.00 26.50  ? 865  THR A O   1 
ATOM   4520 C  CB  . THR A 1 602 ? -23.218 -72.840 -5.973  1.00 31.56  ? 865  THR A CB  1 
ATOM   4521 O  OG1 . THR A 1 602 ? -23.394 -74.171 -6.475  1.00 39.57  ? 865  THR A OG1 1 
ATOM   4522 C  CG2 . THR A 1 602 ? -23.349 -72.769 -4.478  1.00 40.04  ? 865  THR A CG2 1 
ATOM   4523 N  N   . ALA A 1 603 ? -23.481 -69.780 -7.008  1.00 26.87  ? 866  ALA A N   1 
ATOM   4524 C  CA  . ALA A 1 603 ? -23.387 -68.327 -6.755  1.00 24.50  ? 866  ALA A CA  1 
ATOM   4525 C  C   . ALA A 1 603 ? -24.652 -67.683 -7.260  1.00 21.85  ? 866  ALA A C   1 
ATOM   4526 O  O   . ALA A 1 603 ? -25.242 -66.845 -6.550  1.00 24.23  ? 866  ALA A O   1 
ATOM   4527 C  CB  . ALA A 1 603 ? -22.212 -67.767 -7.482  1.00 25.72  ? 866  ALA A CB  1 
ATOM   4528 N  N   . ILE A 1 604 ? -25.081 -68.075 -8.466  1.00 24.64  ? 867  ILE A N   1 
ATOM   4529 C  CA  . ILE A 1 604 ? -26.323 -67.522 -9.058  1.00 25.10  ? 867  ILE A CA  1 
ATOM   4530 C  C   . ILE A 1 604 ? -27.470 -67.792 -8.077  1.00 23.67  ? 867  ILE A C   1 
ATOM   4531 O  O   . ILE A 1 604 ? -28.241 -66.869 -7.763  1.00 24.08  ? 867  ILE A O   1 
ATOM   4532 C  CB  . ILE A 1 604 ? -26.532 -68.114 -10.454 1.00 25.49  ? 867  ILE A CB  1 
ATOM   4533 C  CG1 . ILE A 1 604 ? -25.493 -67.549 -11.420 1.00 23.10  ? 867  ILE A CG1 1 
ATOM   4534 C  CG2 . ILE A 1 604 ? -27.939 -67.903 -10.981 1.00 26.38  ? 867  ILE A CG2 1 
ATOM   4535 C  CD1 . ILE A 1 604 ? -25.384 -68.317 -12.711 1.00 26.90  ? 867  ILE A CD1 1 
ATOM   4536 N  N   . ASN A 1 605 ? -27.528 -69.010 -7.544  1.00 25.73  ? 868  ASN A N   1 
ATOM   4537 C  CA  . ASN A 1 605 ? -28.652 -69.451 -6.673  1.00 29.74  ? 868  ASN A CA  1 
ATOM   4538 C  C   . ASN A 1 605 ? -28.570 -68.697 -5.334  1.00 26.79  ? 868  ASN A C   1 
ATOM   4539 O  O   . ASN A 1 605 ? -29.638 -68.370 -4.813  1.00 25.81  ? 868  ASN A O   1 
ATOM   4540 C  CB  . ASN A 1 605 ? -28.667 -70.972 -6.496  1.00 31.90  ? 868  ASN A CB  1 
ATOM   4541 C  CG  . ASN A 1 605 ? -29.150 -71.685 -7.745  1.00 36.34  ? 868  ASN A CG  1 
ATOM   4542 O  OD1 . ASN A 1 605 ? -29.822 -71.131 -8.618  1.00 43.04  ? 868  ASN A OD1 1 
ATOM   4543 N  ND2 . ASN A 1 605 ? -28.811 -72.938 -7.854  1.00 41.88  ? 868  ASN A ND2 1 
ATOM   4544 N  N   . GLN A 1 606 ? -27.370 -68.342 -4.846  1.00 27.34  ? 869  GLN A N   1 
ATOM   4545 C  CA  . GLN A 1 606 ? -27.246 -67.525 -3.624  1.00 25.25  ? 869  GLN A CA  1 
ATOM   4546 C  C   . GLN A 1 606 ? -27.945 -66.183 -3.811  1.00 25.48  ? 869  GLN A C   1 
ATOM   4547 O  O   . GLN A 1 606 ? -28.704 -65.733 -2.878  1.00 27.68  ? 869  GLN A O   1 
ATOM   4548 C  CB  . GLN A 1 606 ? -25.799 -67.310 -3.168  1.00 26.26  ? 869  GLN A CB  1 
ATOM   4549 C  CG  . GLN A 1 606 ? -25.696 -66.459 -1.900  1.00 33.38  ? 869  GLN A CG  1 
ATOM   4550 C  CD  . GLN A 1 606 ? -24.280 -66.201 -1.426  1.00 36.73  ? 869  GLN A CD  1 
ATOM   4551 O  OE1 . GLN A 1 606 ? -23.343 -66.143 -2.224  1.00 35.62  ? 869  GLN A OE1 1 
ATOM   4552 N  NE2 . GLN A 1 606 ? -24.114 -66.078 -0.120  1.00 32.01  ? 869  GLN A NE2 1 
ATOM   4553 N  N   . VAL A 1 607 ? -27.660 -65.503 -4.913  1.00 23.90  ? 870  VAL A N   1 
ATOM   4554 C  CA  . VAL A 1 607 ? -28.228 -64.158 -5.168  1.00 23.42  ? 870  VAL A CA  1 
ATOM   4555 C  C   . VAL A 1 607 ? -29.757 -64.302 -5.439  1.00 22.85  ? 870  VAL A C   1 
ATOM   4556 O  O   . VAL A 1 607 ? -30.550 -63.561 -4.843  1.00 23.67  ? 870  VAL A O   1 
ATOM   4557 C  CB  . VAL A 1 607 ? -27.471 -63.486 -6.331  1.00 24.35  ? 870  VAL A CB  1 
ATOM   4558 C  CG1 . VAL A 1 607 ? -28.169 -62.198 -6.712  1.00 23.05  ? 870  VAL A CG1 1 
ATOM   4559 C  CG2 . VAL A 1 607 ? -26.012 -63.256 -5.962  1.00 23.62  ? 870  VAL A CG2 1 
ATOM   4560 N  N   . ARG A 1 608 ? -30.188 -65.325 -6.181  1.00 23.86  ? 871  ARG A N   1 
ATOM   4561 C  CA  . ARG A 1 608 ? -31.649 -65.575 -6.429  1.00 27.26  ? 871  ARG A CA  1 
ATOM   4562 C  C   . ARG A 1 608 ? -32.392 -65.759 -5.103  1.00 27.72  ? 871  ARG A C   1 
ATOM   4563 O  O   . ARG A 1 608 ? -33.500 -65.168 -4.945  1.00 29.45  ? 871  ARG A O   1 
ATOM   4564 C  CB  . ARG A 1 608 ? -31.842 -66.781 -7.345  1.00 25.12  ? 871  ARG A CB  1 
ATOM   4565 C  CG  . ARG A 1 608 ? -31.435 -66.518 -8.794  1.00 25.25  ? 871  ARG A CG  1 
ATOM   4566 C  CD  . ARG A 1 608 ? -31.803 -67.771 -9.559  1.00 25.91  ? 871  ARG A CD  1 
ATOM   4567 N  NE  . ARG A 1 608 ? -31.624 -67.590 -10.970 1.00 28.66  ? 871  ARG A NE  1 
ATOM   4568 C  CZ  . ARG A 1 608 ? -31.583 -68.573 -11.839 1.00 30.88  ? 871  ARG A CZ  1 
ATOM   4569 N  NH1 . ARG A 1 608 ? -31.682 -69.833 -11.433 1.00 38.21  ? 871  ARG A NH1 1 
ATOM   4570 N  NH2 . ARG A 1 608 ? -31.391 -68.307 -13.107 1.00 28.56  ? 871  ARG A NH2 1 
ATOM   4571 N  N   . SER A 1 609 ? -31.812 -66.511 -4.175  1.00 26.77  ? 872  SER A N   1 
ATOM   4572 C  CA  . SER A 1 609 ? -32.404 -66.722 -2.831  1.00 27.37  ? 872  SER A CA  1 
ATOM   4573 C  C   . SER A 1 609 ? -32.538 -65.393 -2.095  1.00 26.94  ? 872  SER A C   1 
ATOM   4574 O  O   . SER A 1 609 ? -33.445 -65.302 -1.271  1.00 24.67  ? 872  SER A O   1 
ATOM   4575 C  CB  . SER A 1 609 ? -31.673 -67.737 -2.013  1.00 25.67  ? 872  SER A CB  1 
ATOM   4576 O  OG  . SER A 1 609 ? -31.573 -68.974 -2.728  1.00 27.59  ? 872  SER A OG  1 
ATOM   4577 N  N   . LEU A 1 610 ? -31.570 -64.479 -2.192  1.00 24.97  ? 873  LEU A N   1 
ATOM   4578 C  CA  . LEU A 1 610 ? -31.653 -63.188 -1.474  1.00 24.82  ? 873  LEU A CA  1 
ATOM   4579 C  C   . LEU A 1 610 ? -32.756 -62.328 -2.107  1.00 25.48  ? 873  LEU A C   1 
ATOM   4580 O  O   . LEU A 1 610 ? -33.457 -61.649 -1.385  1.00 24.91  ? 873  LEU A O   1 
ATOM   4581 C  CB  . LEU A 1 610 ? -30.286 -62.495 -1.495  1.00 25.99  ? 873  LEU A CB  1 
ATOM   4582 C  CG  . LEU A 1 610 ? -29.149 -63.182 -0.756  1.00 25.10  ? 873  LEU A CG  1 
ATOM   4583 C  CD1 . LEU A 1 610 ? -27.797 -62.540 -1.054  1.00 30.32  ? 873  LEU A CD1 1 
ATOM   4584 C  CD2 . LEU A 1 610 ? -29.440 -63.204 0.747   1.00 25.71  ? 873  LEU A CD2 1 
ATOM   4585 N  N   . ILE A 1 611 ? -32.834 -62.265 -3.439  1.00 25.71  ? 874  ILE A N   1 
ATOM   4586 C  CA  . ILE A 1 611 ? -33.805 -61.387 -4.146  1.00 25.27  ? 874  ILE A CA  1 
ATOM   4587 C  C   . ILE A 1 611 ? -35.227 -61.960 -3.951  1.00 30.00  ? 874  ILE A C   1 
ATOM   4588 O  O   . ILE A 1 611 ? -36.155 -61.178 -3.704  1.00 28.55  ? 874  ILE A O   1 
ATOM   4589 C  CB  . ILE A 1 611 ? -33.399 -61.228 -5.639  1.00 26.60  ? 874  ILE A CB  1 
ATOM   4590 C  CG1 . ILE A 1 611 ? -32.081 -60.469 -5.761  1.00 24.72  ? 874  ILE A CG1 1 
ATOM   4591 C  CG2 . ILE A 1 611 ? -34.494 -60.479 -6.397  1.00 26.69  ? 874  ILE A CG2 1 
ATOM   4592 C  CD1 . ILE A 1 611 ? -31.496 -60.330 -7.140  1.00 26.25  ? 874  ILE A CD1 1 
ATOM   4593 N  N   . GLY A 1 612 ? -35.350 -63.287 -3.957  1.00 27.15  ? 875  GLY A N   1 
ATOM   4594 C  CA  . GLY A 1 612 ? -36.573 -64.071 -3.649  1.00 32.54  ? 875  GLY A CA  1 
ATOM   4595 C  C   . GLY A 1 612 ? -37.169 -64.781 -4.864  1.00 31.28  ? 875  GLY A C   1 
ATOM   4596 O  O   . GLY A 1 612 ? -36.559 -64.831 -5.926  1.00 31.69  ? 875  GLY A O   1 
ATOM   4597 N  N   . ASN A 1 613 ? -38.459 -65.072 -4.790  1.00 38.11  ? 876  ASN A N   1 
ATOM   4598 C  CA  . ASN A 1 613 ? -39.213 -65.902 -5.765  1.00 38.39  ? 876  ASN A CA  1 
ATOM   4599 C  C   . ASN A 1 613 ? -39.718 -65.032 -6.931  1.00 39.05  ? 876  ASN A C   1 
ATOM   4600 O  O   . ASN A 1 613 ? -40.856 -64.567 -6.901  1.00 48.51  ? 876  ASN A O   1 
ATOM   4601 C  CB  . ASN A 1 613 ? -40.353 -66.613 -5.025  1.00 46.54  ? 876  ASN A CB  1 
ATOM   4602 C  CG  . ASN A 1 613 ? -41.097 -67.585 -5.912  1.00 51.74  ? 876  ASN A CG  1 
ATOM   4603 O  OD1 . ASN A 1 613 ? -40.589 -67.984 -6.947  1.00 48.26  ? 876  ASN A OD1 1 
ATOM   4604 N  ND2 . ASN A 1 613 ? -42.280 -68.008 -5.484  1.00 55.83  ? 876  ASN A ND2 1 
ATOM   4605 N  N   . GLU A 1 614 ? -38.911 -64.894 -7.962  1.00 29.68  ? 877  GLU A N   1 
ATOM   4606 C  CA  . GLU A 1 614 ? -39.066 -63.924 -9.068  1.00 27.12  ? 877  GLU A CA  1 
ATOM   4607 C  C   . GLU A 1 614 ? -38.897 -64.762 -10.335 1.00 25.32  ? 877  GLU A C   1 
ATOM   4608 O  O   . GLU A 1 614 ? -38.640 -65.977 -10.226 1.00 30.67  ? 877  GLU A O   1 
ATOM   4609 C  CB  . GLU A 1 614 ? -38.024 -62.808 -8.976  1.00 27.34  ? 877  GLU A CB  1 
ATOM   4610 C  CG  . GLU A 1 614 ? -38.213 -61.885 -7.792  1.00 26.92  ? 877  GLU A CG  1 
ATOM   4611 C  CD  . GLU A 1 614 ? -39.405 -60.927 -7.820  1.00 30.50  ? 877  GLU A CD  1 
ATOM   4612 O  OE1 . GLU A 1 614 ? -40.002 -60.653 -8.901  1.00 28.09  ? 877  GLU A OE1 1 
ATOM   4613 O  OE2 . GLU A 1 614 ? -39.657 -60.367 -6.754  1.00 29.67  ? 877  GLU A OE2 1 
ATOM   4614 N  N   . GLU A 1 615 ? -39.156 -64.203 -11.488 1.00 32.15  ? 878  GLU A N   1 
ATOM   4615 C  CA  . GLU A 1 615 ? -38.948 -64.963 -12.751 1.00 33.72  ? 878  GLU A CA  1 
ATOM   4616 C  C   . GLU A 1 615 ? -37.503 -64.686 -13.174 1.00 31.93  ? 878  GLU A C   1 
ATOM   4617 O  O   . GLU A 1 615 ? -37.211 -63.486 -13.470 1.00 32.33  ? 878  GLU A O   1 
ATOM   4618 C  CB  . GLU A 1 615 ? -39.918 -64.550 -13.877 1.00 37.38  ? 878  GLU A CB  1 
ATOM   4619 C  CG  . GLU A 1 615 ? -39.655 -65.370 -15.153 1.00 48.40  ? 878  GLU A CG  1 
ATOM   4620 C  CD  . GLU A 1 615 ? -40.530 -65.080 -16.379 1.00 65.87  ? 878  GLU A CD  1 
ATOM   4621 O  OE1 . GLU A 1 615 ? -41.404 -64.156 -16.322 1.00 58.89  ? 878  GLU A OE1 1 
ATOM   4622 O  OE2 . GLU A 1 615 ? -40.345 -65.788 -17.412 1.00 83.07  ? 878  GLU A OE2 1 
ATOM   4623 N  N   . TYR A 1 616 ? -36.696 -65.744 -13.306 1.00 33.50  ? 879  TYR A N   1 
ATOM   4624 C  CA  . TYR A 1 616 ? -35.288 -65.721 -13.777 1.00 33.45  ? 879  TYR A CA  1 
ATOM   4625 C  C   . TYR A 1 616 ? -35.122 -66.577 -15.039 1.00 37.21  ? 879  TYR A C   1 
ATOM   4626 O  O   . TYR A 1 616 ? -35.911 -67.499 -15.259 1.00 30.08  ? 879  TYR A O   1 
ATOM   4627 C  CB  . TYR A 1 616 ? -34.371 -66.261 -12.691 1.00 33.96  ? 879  TYR A CB  1 
ATOM   4628 C  CG  . TYR A 1 616 ? -34.485 -65.584 -11.345 1.00 27.58  ? 879  TYR A CG  1 
ATOM   4629 C  CD1 . TYR A 1 616 ? -33.716 -64.486 -11.020 1.00 24.62  ? 879  TYR A CD1 1 
ATOM   4630 C  CD2 . TYR A 1 616 ? -35.291 -66.125 -10.352 1.00 27.91  ? 879  TYR A CD2 1 
ATOM   4631 C  CE1 . TYR A 1 616 ? -33.804 -63.893 -9.754  1.00 28.28  ? 879  TYR A CE1 1 
ATOM   4632 C  CE2 . TYR A 1 616 ? -35.404 -65.538 -9.097  1.00 26.59  ? 879  TYR A CE2 1 
ATOM   4633 C  CZ  . TYR A 1 616 ? -34.617 -64.441 -8.769  1.00 26.76  ? 879  TYR A CZ  1 
ATOM   4634 O  OH  . TYR A 1 616 ? -34.656 -63.873 -7.497  1.00 29.58  ? 879  TYR A OH  1 
ATOM   4635 N  N   . THR A 1 617 ? -34.130 -66.232 -15.867 1.00 33.83  ? 880  THR A N   1 
ATOM   4636 C  CA  . THR A 1 617 ? -33.648 -67.017 -17.053 1.00 37.57  ? 880  THR A CA  1 
ATOM   4637 C  C   . THR A 1 617 ? -32.218 -67.515 -16.809 1.00 32.00  ? 880  THR A C   1 
ATOM   4638 O  O   . THR A 1 617 ? -31.418 -66.753 -16.202 1.00 30.63  ? 880  THR A O   1 
ATOM   4639 C  CB  . THR A 1 617 ? -33.638 -66.111 -18.281 1.00 42.76  ? 880  THR A CB  1 
ATOM   4640 O  OG1 . THR A 1 617 ? -34.919 -65.473 -18.265 1.00 37.83  ? 880  THR A OG1 1 
ATOM   4641 C  CG2 . THR A 1 617 ? -33.346 -66.845 -19.579 1.00 43.81  ? 880  THR A CG2 1 
ATOM   4642 N  N   . ASP A 1 618 ? -31.908 -68.765 -17.164 1.00 30.45  ? 881  ASP A N   1 
ATOM   4643 C  CA  . ASP A 1 618 ? -30.511 -69.272 -17.124 1.00 36.22  ? 881  ASP A CA  1 
ATOM   4644 C  C   . ASP A 1 618 ? -29.824 -68.835 -18.430 1.00 35.08  ? 881  ASP A C   1 
ATOM   4645 O  O   . ASP A 1 618 ? -30.110 -69.439 -19.490 1.00 29.93  ? 881  ASP A O   1 
ATOM   4646 C  CB  . ASP A 1 618 ? -30.466 -70.794 -16.946 1.00 39.32  ? 881  ASP A CB  1 
ATOM   4647 C  CG  . ASP A 1 618 ? -29.056 -71.384 -16.840 1.00 45.29  ? 881  ASP A CG  1 
ATOM   4648 O  OD1 . ASP A 1 618 ? -28.084 -70.615 -16.592 1.00 37.14  ? 881  ASP A OD1 1 
ATOM   4649 O  OD2 . ASP A 1 618 ? -28.938 -72.618 -16.924 1.00 45.15  ? 881  ASP A OD2 1 
ATOM   4650 N  N   . TYR A 1 619 ? -28.895 -67.870 -18.372 1.00 31.98  ? 882  TYR A N   1 
ATOM   4651 C  CA  . TYR A 1 619 ? -28.088 -67.522 -19.573 1.00 30.01  ? 882  TYR A CA  1 
ATOM   4652 C  C   . TYR A 1 619 ? -26.794 -68.330 -19.646 1.00 31.64  ? 882  TYR A C   1 
ATOM   4653 O  O   . TYR A 1 619 ? -26.097 -68.158 -20.628 1.00 34.02  ? 882  TYR A O   1 
ATOM   4654 C  CB  . TYR A 1 619 ? -27.812 -66.029 -19.628 1.00 32.19  ? 882  TYR A CB  1 
ATOM   4655 C  CG  . TYR A 1 619 ? -29.052 -65.206 -19.789 1.00 35.71  ? 882  TYR A CG  1 
ATOM   4656 C  CD1 . TYR A 1 619 ? -29.727 -65.143 -21.004 1.00 35.01  ? 882  TYR A CD1 1 
ATOM   4657 C  CD2 . TYR A 1 619 ? -29.548 -64.477 -18.724 1.00 29.70  ? 882  TYR A CD2 1 
ATOM   4658 C  CE1 . TYR A 1 619 ? -30.879 -64.373 -21.149 1.00 35.95  ? 882  TYR A CE1 1 
ATOM   4659 C  CE2 . TYR A 1 619 ? -30.703 -63.709 -18.851 1.00 32.92  ? 882  TYR A CE2 1 
ATOM   4660 C  CZ  . TYR A 1 619 ? -31.347 -63.623 -20.078 1.00 35.51  ? 882  TYR A CZ  1 
ATOM   4661 O  OH  . TYR A 1 619 ? -32.457 -62.844 -20.174 1.00 36.07  ? 882  TYR A OH  1 
ATOM   4662 N  N   . MET A 1 620 ? -26.436 -69.163 -18.674 1.00 35.59  ? 883  MET A N   1 
ATOM   4663 C  CA  . MET A 1 620 ? -25.126 -69.874 -18.738 1.00 34.53  ? 883  MET A CA  1 
ATOM   4664 C  C   . MET A 1 620 ? -24.997 -70.828 -19.960 1.00 36.85  ? 883  MET A C   1 
ATOM   4665 O  O   . MET A 1 620 ? -23.892 -70.878 -20.525 1.00 40.30  ? 883  MET A O   1 
ATOM   4666 C  CB  . MET A 1 620 ? -24.747 -70.564 -17.427 1.00 33.79  ? 883  MET A CB  1 
ATOM   4667 C  CG  . MET A 1 620 ? -24.865 -69.673 -16.156 1.00 31.24  ? 883  MET A CG  1 
ATOM   4668 S  SD  . MET A 1 620 ? -24.065 -68.021 -16.315 1.00 32.26  ? 883  MET A SD  1 
ATOM   4669 C  CE  . MET A 1 620 ? -22.358 -68.485 -16.604 1.00 30.60  ? 883  MET A CE  1 
ATOM   4670 N  N   . PRO A 1 621 ? -26.023 -71.606 -20.426 1.00 42.07  ? 884  PRO A N   1 
ATOM   4671 C  CA  . PRO A 1 621 ? -25.886 -72.479 -21.621 1.00 44.06  ? 884  PRO A CA  1 
ATOM   4672 C  C   . PRO A 1 621 ? -25.651 -71.822 -22.999 1.00 46.42  ? 884  PRO A C   1 
ATOM   4673 O  O   . PRO A 1 621 ? -25.390 -72.562 -23.956 1.00 52.64  ? 884  PRO A O   1 
ATOM   4674 C  CB  . PRO A 1 621 ? -27.226 -73.273 -21.682 1.00 43.55  ? 884  PRO A CB  1 
ATOM   4675 C  CG  . PRO A 1 621 ? -27.801 -73.208 -20.262 1.00 45.00  ? 884  PRO A CG  1 
ATOM   4676 C  CD  . PRO A 1 621 ? -27.309 -71.865 -19.728 1.00 46.93  ? 884  PRO A CD  1 
ATOM   4677 N  N   . SER A 1 622 ? -25.711 -70.478 -23.078 1.00 45.37  ? 885  SER A N   1 
ATOM   4678 C  CA  . SER A 1 622 ? -25.203 -69.631 -24.199 1.00 45.65  ? 885  SER A CA  1 
ATOM   4679 C  C   . SER A 1 622 ? -23.674 -69.793 -24.336 1.00 51.07  ? 885  SER A C   1 
ATOM   4680 O  O   . SER A 1 622 ? -23.141 -69.413 -25.415 1.00 46.23  ? 885  SER A O   1 
ATOM   4681 C  CB  . SER A 1 622 ? -25.578 -68.159 -24.026 1.00 47.50  ? 885  SER A CB  1 
ATOM   4682 O  OG  . SER A 1 622 ? -24.805 -67.504 -23.008 1.00 37.28  ? 885  SER A OG  1 
ATOM   4683 N  N   . MET A 1 623 ? -22.997 -70.291 -23.284 1.00 40.28  ? 886  MET A N   1 
ATOM   4684 C  CA  . MET A 1 623 ? -21.553 -70.619 -23.299 1.00 51.15  ? 886  MET A CA  1 
ATOM   4685 C  C   . MET A 1 623 ? -21.376 -72.128 -23.512 1.00 55.84  ? 886  MET A C   1 
ATOM   4686 O  O   . MET A 1 623 ? -22.072 -72.905 -22.798 1.00 44.68  ? 886  MET A O   1 
ATOM   4687 C  CB  . MET A 1 623 ? -20.893 -70.232 -21.969 1.00 55.85  ? 886  MET A CB  1 
ATOM   4688 C  CG  . MET A 1 623 ? -21.273 -68.860 -21.490 1.00 56.80  ? 886  MET A CG  1 
ATOM   4689 S  SD  . MET A 1 623 ? -20.379 -68.391 -19.974 1.00 49.27  ? 886  MET A SD  1 
ATOM   4690 C  CE  . MET A 1 623 ? -18.888 -67.739 -20.698 1.00 42.78  ? 886  MET A CE  1 
ATOM   4691 N  N   . LYS A 1 624 ? -20.406 -72.506 -24.356 1.00 58.96  ? 887  LYS A N   1 
ATOM   4692 C  CA  . LYS A 1 624 ? -20.085 -73.910 -24.740 1.00 66.30  ? 887  LYS A CA  1 
ATOM   4693 C  C   . LYS A 1 624 ? -20.015 -74.857 -23.518 1.00 60.67  ? 887  LYS A C   1 
ATOM   4694 O  O   . LYS A 1 624 ? -20.675 -75.921 -23.540 1.00 57.12  ? 887  LYS A O   1 
ATOM   4695 C  CB  . LYS A 1 624 ? -18.779 -73.938 -25.553 1.00 74.74  ? 887  LYS A CB  1 
ATOM   4696 C  CG  . LYS A 1 624 ? -18.456 -75.271 -26.232 1.00 80.92  ? 887  LYS A CG  1 
ATOM   4697 C  CD  . LYS A 1 624 ? -17.463 -75.173 -27.400 1.00 91.63  ? 887  LYS A CD  1 
ATOM   4698 C  CE  . LYS A 1 624 ? -16.000 -75.331 -27.012 1.00 97.86  ? 887  LYS A CE  1 
ATOM   4699 N  NZ  . LYS A 1 624 ? -15.427 -74.080 -26.453 1.00 97.13  ? 887  LYS A NZ  1 
ATOM   4700 N  N   . ARG A 1 625 ? -19.256 -74.472 -22.484 0.46 59.53  ? 888  ARG A N   1 
ATOM   4701 C  CA  . ARG A 1 625 ? -18.914 -75.340 -21.319 0.46 58.58  ? 888  ARG A CA  1 
ATOM   4702 C  C   . ARG A 1 625 ? -20.153 -75.646 -20.461 0.46 56.35  ? 888  ARG A C   1 
ATOM   4703 O  O   . ARG A 1 625 ? -20.117 -76.663 -19.747 0.46 52.87  ? 888  ARG A O   1 
ATOM   4704 C  CB  . ARG A 1 625 ? -17.816 -74.698 -20.461 0.46 58.98  ? 888  ARG A CB  1 
ATOM   4705 C  CG  . ARG A 1 625 ? -18.226 -73.416 -19.749 0.46 57.60  ? 888  ARG A CG  1 
ATOM   4706 C  CD  . ARG A 1 625 ? -17.186 -72.966 -18.734 0.46 57.55  ? 888  ARG A CD  1 
ATOM   4707 N  NE  . ARG A 1 625 ? -17.029 -73.938 -17.661 0.46 57.02  ? 888  ARG A NE  1 
ATOM   4708 C  CZ  . ARG A 1 625 ? -15.982 -74.011 -16.848 0.46 56.20  ? 888  ARG A CZ  1 
ATOM   4709 N  NH1 . ARG A 1 625 ? -14.974 -73.163 -16.976 0.46 58.30  ? 888  ARG A NH1 1 
ATOM   4710 N  NH2 . ARG A 1 625 ? -15.947 -74.938 -15.907 0.46 52.95  ? 888  ARG A NH2 1 
ATOM   4711 N  N   . PHE A 1 626 ? -21.197 -74.808 -20.511 1.00 55.04  ? 889  PHE A N   1 
ATOM   4712 C  CA  . PHE A 1 626 ? -22.440 -74.993 -19.694 1.00 56.36  ? 889  PHE A CA  1 
ATOM   4713 C  C   . PHE A 1 626 ? -23.544 -75.574 -20.590 1.00 66.26  ? 889  PHE A C   1 
ATOM   4714 O  O   . PHE A 1 626 ? -24.671 -75.915 -20.117 1.00 60.67  ? 889  PHE A O   1 
ATOM   4715 C  CB  . PHE A 1 626 ? -22.855 -73.680 -19.008 1.00 50.38  ? 889  PHE A CB  1 
ATOM   4716 C  CG  . PHE A 1 626 ? -21.799 -73.093 -18.099 1.00 54.87  ? 889  PHE A CG  1 
ATOM   4717 C  CD1 . PHE A 1 626 ? -21.402 -73.755 -16.937 1.00 54.77  ? 889  PHE A CD1 1 
ATOM   4718 C  CD2 . PHE A 1 626 ? -21.166 -71.898 -18.421 1.00 51.28  ? 889  PHE A CD2 1 
ATOM   4719 C  CE1 . PHE A 1 626 ? -20.401 -73.237 -16.123 1.00 59.75  ? 889  PHE A CE1 1 
ATOM   4720 C  CE2 . PHE A 1 626 ? -20.183 -71.367 -17.594 1.00 52.59  ? 889  PHE A CE2 1 
ATOM   4721 C  CZ  . PHE A 1 626 ? -19.799 -72.034 -16.442 1.00 53.80  ? 889  PHE A CZ  1 
ATOM   4722 N  N   . ARG A 1 627 ? -23.254 -75.671 -21.882 1.00 76.96  ? 890  ARG A N   1 
ATOM   4723 C  CA  . ARG A 1 627 ? -24.125 -76.374 -22.852 1.00 99.50  ? 890  ARG A CA  1 
ATOM   4724 C  C   . ARG A 1 627 ? -23.881 -77.871 -22.600 1.00 112.27 ? 890  ARG A C   1 
ATOM   4725 O  O   . ARG A 1 627 ? -23.107 -78.495 -23.355 1.00 125.12 ? 890  ARG A O   1 
ATOM   4726 C  CB  . ARG A 1 627 ? -23.815 -75.837 -24.256 1.00 97.04  ? 890  ARG A CB  1 
ATOM   4727 C  CG  . ARG A 1 627 ? -25.015 -75.716 -25.181 1.00 92.24  ? 890  ARG A CG  1 
ATOM   4728 C  CD  . ARG A 1 627 ? -24.663 -74.904 -26.411 1.00 94.54  ? 890  ARG A CD  1 
ATOM   4729 N  NE  . ARG A 1 627 ? -23.298 -75.153 -26.867 1.00 93.43  ? 890  ARG A NE  1 
ATOM   4730 C  CZ  . ARG A 1 627 ? -22.890 -76.189 -27.611 1.00 92.84  ? 890  ARG A CZ  1 
ATOM   4731 N  NH1 . ARG A 1 627 ? -23.735 -77.122 -28.017 1.00 97.40  ? 890  ARG A NH1 1 
ATOM   4732 N  NH2 . ARG A 1 627 ? -21.619 -76.292 -27.956 1.00 90.16  ? 890  ARG A NH2 1 
ATOM   4733 N  N   . ARG A 1 628 ? -24.504 -78.408 -21.542 0.46 109.99 ? 891  ARG A N   1 
ATOM   4734 C  CA  . ARG A 1 628 ? -24.378 -79.816 -21.068 0.46 106.95 ? 891  ARG A CA  1 
ATOM   4735 C  C   . ARG A 1 628 ? -22.917 -80.274 -21.168 0.46 106.79 ? 891  ARG A C   1 
ATOM   4736 O  O   . ARG A 1 628 ? -22.580 -81.192 -21.919 0.46 102.24 ? 891  ARG A O   1 
ATOM   4737 C  CB  . ARG A 1 628 ? -25.312 -80.730 -21.868 0.46 105.93 ? 891  ARG A CB  1 
ATOM   4738 C  CG  . ARG A 1 628 ? -25.184 -82.206 -21.520 0.46 103.73 ? 891  ARG A CG  1 
ATOM   4739 C  CD  . ARG A 1 628 ? -26.531 -82.836 -21.225 0.46 102.73 ? 891  ARG A CD  1 
ATOM   4740 N  NE  . ARG A 1 628 ? -27.130 -82.279 -20.020 0.46 102.76 ? 891  ARG A NE  1 
ATOM   4741 C  CZ  . ARG A 1 628 ? -26.892 -82.719 -18.789 0.46 100.63 ? 891  ARG A CZ  1 
ATOM   4742 N  NH1 . ARG A 1 628 ? -27.482 -82.149 -17.753 0.46 97.49  ? 891  ARG A NH1 1 
ATOM   4743 N  NH2 . ARG A 1 628 ? -26.063 -83.729 -18.598 0.46 101.71 ? 891  ARG A NH2 1 
HETATM 4744 ZN ZN  . ZN  B 2 .   ? -6.530  -55.518 -23.796 1.00 21.84  2 1001 ZN  A ZN  1 
HETATM 4745 ZN ZN  . ZN  C 2 .   ? -25.929 -14.770 -13.306 1.00 53.18  2 1002 ZN  A ZN  1 
HETATM 4746 O  O1  A MES D 3 .   ? -28.475 -57.781 0.453   0.25 30.31  ? 1003 MES A O1  1 
HETATM 4747 O  O1  B MES D 3 .   ? -28.336 -57.695 0.311   0.25 638.33 ? 1003 MES A O1  1 
HETATM 4748 C  C2  A MES D 3 .   ? -27.837 -58.275 1.621   0.25 27.83  ? 1003 MES A C2  1 
HETATM 4749 C  C2  B MES D 3 .   ? -27.634 -58.195 1.439   0.25 647.49 ? 1003 MES A C2  1 
HETATM 4750 C  C3  A MES D 3 .   ? -26.394 -57.841 1.665   0.25 28.23  ? 1003 MES A C3  1 
HETATM 4751 C  C3  B MES D 3 .   ? -26.144 -58.184 1.207   0.25 651.00 ? 1003 MES A C3  1 
HETATM 4752 N  N4  A MES D 3 .   ? -25.672 -58.343 0.457   0.25 25.42  ? 1003 MES A N4  1 
HETATM 4753 N  N4  B MES D 3 .   ? -25.808 -59.005 0.003   0.25 652.30 ? 1003 MES A N4  1 
HETATM 4754 C  C5  A MES D 3 .   ? -26.380 -57.884 -0.772  0.25 27.34  ? 1003 MES A C5  1 
HETATM 4755 C  C5  B MES D 3 .   ? -26.598 -58.503 -1.163  0.25 640.04 ? 1003 MES A C5  1 
HETATM 4756 C  C6  A MES D 3 .   ? -27.839 -58.267 -0.721  0.25 28.28  ? 1003 MES A C6  1 
HETATM 4757 C  C6  B MES D 3 .   ? -28.066 -58.504 -0.824  0.25 630.16 ? 1003 MES A C6  1 
HETATM 4758 C  C7  A MES D 3 .   ? -24.238 -57.901 0.469   0.25 25.60  ? 1003 MES A C7  1 
HETATM 4759 C  C7  B MES D 3 .   ? -24.336 -59.005 -0.287  0.25 665.19 ? 1003 MES A C7  1 
HETATM 4760 C  C8  A MES D 3 .   ? -23.306 -58.861 -0.247  0.25 25.81  ? 1003 MES A C8  1 
HETATM 4761 C  C8  B MES D 3 .   ? -23.590 -57.877 0.398   0.25 688.68 ? 1003 MES A C8  1 
HETATM 4762 S  S   A MES D 3 .   ? -21.583 -58.408 -0.045  0.25 25.56  ? 1003 MES A S   1 
HETATM 4763 S  S   B MES D 3 .   ? -21.830 -58.133 0.393   0.25 720.36 ? 1003 MES A S   1 
HETATM 4764 O  O1S A MES D 3 .   ? -21.225 -58.767 1.271   0.25 21.20  ? 1003 MES A O1S 1 
HETATM 4765 O  O1S B MES D 3 .   ? -21.632 -59.520 0.076   0.25 732.69 ? 1003 MES A O1S 1 
HETATM 4766 O  O2S A MES D 3 .   ? -20.916 -59.158 -1.104  0.25 25.23  ? 1003 MES A O2S 1 
HETATM 4767 O  O2S B MES D 3 .   ? -21.302 -57.256 -0.613  0.25 716.30 ? 1003 MES A O2S 1 
HETATM 4768 O  O3S A MES D 3 .   ? -21.516 -56.993 -0.321  0.25 23.97  ? 1003 MES A O3S 1 
HETATM 4769 O  O3S B MES D 3 .   ? -21.373 -57.797 1.711   0.25 728.09 ? 1003 MES A O3S 1 
HETATM 4770 S  S   . DMS E 4 .   ? -26.871 -62.284 -21.080 1.00 47.24  ? 1004 DMS A S   1 
HETATM 4771 O  O   . DMS E 4 .   ? -26.635 -62.823 -22.546 1.00 49.35  ? 1004 DMS A O   1 
HETATM 4772 C  C1  . DMS E 4 .   ? -28.147 -61.067 -21.156 1.00 43.52  ? 1004 DMS A C1  1 
HETATM 4773 C  C2  . DMS E 4 .   ? -25.487 -61.151 -20.907 1.00 49.84  ? 1004 DMS A C2  1 
HETATM 4774 S  S   . DMS F 4 .   ? -15.759 -69.665 -29.005 1.00 115.02 ? 1005 DMS A S   1 
HETATM 4775 O  O   . DMS F 4 .   ? -16.158 -68.216 -29.242 1.00 72.14  ? 1005 DMS A O   1 
HETATM 4776 C  C1  . DMS F 4 .   ? -16.783 -70.265 -27.668 1.00 96.91  ? 1005 DMS A C1  1 
HETATM 4777 C  C2  . DMS F 4 .   ? -14.196 -69.668 -28.142 1.00 103.03 ? 1005 DMS A C2  1 
HETATM 4778 S  S   . DMS G 4 .   ? -23.104 -48.315 -16.261 1.00 58.53  ? 1006 DMS A S   1 
HETATM 4779 O  O   . DMS G 4 .   ? -24.233 -47.997 -17.230 1.00 54.16  ? 1006 DMS A O   1 
HETATM 4780 C  C1  . DMS G 4 .   ? -21.664 -47.679 -17.063 1.00 55.03  ? 1006 DMS A C1  1 
HETATM 4781 C  C2  . DMS G 4 .   ? -22.732 -49.987 -16.503 1.00 47.38  ? 1006 DMS A C2  1 
HETATM 4782 C  C1  . PEG H 5 .   ? -30.798 -47.207 -24.917 1.00 97.04  ? 1007 PEG A C1  1 
HETATM 4783 O  O1  . PEG H 5 .   ? -30.229 -47.280 -26.211 1.00 90.76  ? 1007 PEG A O1  1 
HETATM 4784 C  C2  . PEG H 5 .   ? -31.251 -45.819 -24.568 1.00 108.48 ? 1007 PEG A C2  1 
HETATM 4785 O  O2  . PEG H 5 .   ? -31.679 -45.778 -23.206 1.00 111.93 ? 1007 PEG A O2  1 
HETATM 4786 C  C3  . PEG H 5 .   ? -31.663 -44.470 -22.638 1.00 110.21 ? 1007 PEG A C3  1 
HETATM 4787 C  C4  . PEG H 5 .   ? -30.310 -44.180 -22.050 1.00 103.73 ? 1007 PEG A C4  1 
HETATM 4788 O  O4  . PEG H 5 .   ? -30.185 -44.614 -20.710 1.00 88.70  ? 1007 PEG A O4  1 
HETATM 4789 P  P   . PO4 I 6 .   ? -4.149  -39.595 -23.988 1.00 58.64  ? 1008 PO4 A P   1 
HETATM 4790 O  O1  . PO4 I 6 .   ? -2.803  -40.370 -23.336 1.00 38.67  ? 1008 PO4 A O1  1 
HETATM 4791 O  O2  . PO4 I 6 .   ? -3.749  -38.099 -24.709 1.00 34.75  ? 1008 PO4 A O2  1 
HETATM 4792 O  O3  . PO4 I 6 .   ? -4.841  -40.507 -25.155 1.00 45.62  ? 1008 PO4 A O3  1 
HETATM 4793 O  O4  . PO4 I 6 .   ? -5.108  -39.366 -22.867 1.00 61.59  ? 1008 PO4 A O4  1 
HETATM 4794 P  P   . PO4 J 6 .   ? -18.167 -9.661  -28.967 1.00 106.77 ? 1009 PO4 A P   1 
HETATM 4795 O  O1  . PO4 J 6 .   ? -17.859 -10.138 -27.513 1.00 66.53  ? 1009 PO4 A O1  1 
HETATM 4796 O  O2  . PO4 J 6 .   ? -16.823 -9.427  -29.685 1.00 89.81  ? 1009 PO4 A O2  1 
HETATM 4797 O  O3  . PO4 J 6 .   ? -19.004 -10.755 -29.718 1.00 78.55  ? 1009 PO4 A O3  1 
HETATM 4798 O  O4  . PO4 J 6 .   ? -18.977 -8.312  -28.968 1.00 71.13  ? 1009 PO4 A O4  1 
HETATM 4799 C  C1  . PEG K 5 .   ? -16.762 -43.978 -41.068 1.00 67.49  ? 1010 PEG A C1  1 
HETATM 4800 O  O1  . PEG K 5 .   ? -18.159 -44.082 -41.261 1.00 61.51  ? 1010 PEG A O1  1 
HETATM 4801 C  C2  . PEG K 5 .   ? -16.010 -44.387 -42.281 1.00 69.51  ? 1010 PEG A C2  1 
HETATM 4802 O  O2  . PEG K 5 .   ? -16.302 -45.753 -42.559 1.00 76.41  ? 1010 PEG A O2  1 
HETATM 4803 C  C3  . PEG K 5 .   ? -15.990 -46.153 -43.889 1.00 76.36  ? 1010 PEG A C3  1 
HETATM 4804 C  C4  . PEG K 5 .   ? -15.039 -47.315 -43.862 1.00 81.59  ? 1010 PEG A C4  1 
HETATM 4805 O  O4  . PEG K 5 .   ? -15.551 -48.471 -44.509 1.00 76.55  ? 1010 PEG A O4  1 
HETATM 4806 C  C4  . WHM L 7 .   ? -7.512  -71.777 -19.570 0.48 95.76  ? 1011 WHM A C4  1 
HETATM 4807 C  C5  . WHM L 7 .   ? -6.047  -71.930 -19.237 0.48 102.30 ? 1011 WHM A C5  1 
HETATM 4808 C  C6  . WHM L 7 .   ? -4.704  -72.348 -21.364 0.48 108.17 ? 1011 WHM A C6  1 
HETATM 4809 C  C7  . WHM L 7 .   ? -3.571  -73.060 -20.685 0.48 107.38 ? 1011 WHM A C7  1 
HETATM 4810 C  C8  . WHM L 7 .   ? -2.635  -71.934 -20.295 0.48 109.49 ? 1011 WHM A C8  1 
HETATM 4811 N  N   . WHM L 7 .   ? -5.150  -71.425 -20.300 0.48 109.92 ? 1011 WHM A N   1 
HETATM 4812 C  C   . WHM L 7 .   ? -9.250  -71.045 -21.018 0.48 93.73  ? 1011 WHM A C   1 
HETATM 4813 O  O   . WHM L 7 .   ? -3.764  -70.181 -18.645 0.48 110.12 ? 1011 WHM A O   1 
HETATM 4814 C  C1  . WHM L 7 .   ? -10.227 -71.439 -20.151 0.48 92.23  ? 1011 WHM A C1  1 
HETATM 4815 C  C2  . WHM L 7 .   ? -9.832  -72.018 -18.960 0.48 92.75  ? 1011 WHM A C2  1 
HETATM 4816 C  C3  . WHM L 7 .   ? -8.487  -72.186 -18.674 0.48 94.76  ? 1011 WHM A C3  1 
HETATM 4817 C  C9  . WHM L 7 .   ? -7.911  -71.201 -20.770 0.48 94.08  ? 1011 WHM A C9  1 
HETATM 4818 F  F   . WHM L 7 .   ? -9.618  -70.431 -22.164 0.48 92.85  ? 1011 WHM A F   1 
HETATM 4819 O  O1  . WHM L 7 .   ? -3.628  -69.566 -21.000 0.48 113.13 ? 1011 WHM A O1  1 
HETATM 4820 S  S   . WHM L 7 .   ? -3.770  -70.587 -20.013 0.48 112.71 ? 1011 WHM A S   1 
HETATM 4821 O  O   . HOH M 8 .   ? -13.047 -22.271 -41.765 1.00 44.12  ? 1101 HOH A O   1 
HETATM 4822 O  O   . HOH M 8 .   ? -32.024 -70.935 -8.786  1.00 49.39  ? 1102 HOH A O   1 
HETATM 4823 O  O   . HOH M 8 .   ? -32.722 -52.182 -27.368 1.00 40.37  ? 1103 HOH A O   1 
HETATM 4824 O  O   . HOH M 8 .   ? -11.697 -12.262 -9.078  1.00 61.10  ? 1104 HOH A O   1 
HETATM 4825 O  O   . HOH M 8 .   ? -32.421 -60.834 -19.039 1.00 44.10  ? 1105 HOH A O   1 
HETATM 4826 O  O   . HOH M 8 .   ? -33.706 -47.890 -4.387  1.00 37.09  ? 1106 HOH A O   1 
HETATM 4827 O  O   . HOH M 8 .   ? -22.365 -53.848 -46.743 1.00 50.85  ? 1107 HOH A O   1 
HETATM 4828 O  O   . HOH M 8 .   ? -21.945 -10.207 -9.760  1.00 56.16  ? 1108 HOH A O   1 
HETATM 4829 O  O   . HOH M 8 .   ? -34.844 -20.840 -23.967 1.00 55.17  ? 1109 HOH A O   1 
HETATM 4830 O  O   . HOH M 8 .   ? -1.537  -69.912 -17.824 0.48 30.82  ? 1110 HOH A O   1 
HETATM 4831 O  O   . HOH M 8 .   ? -7.636  -49.047 0.798   1.00 50.57  ? 1111 HOH A O   1 
HETATM 4832 O  O   . HOH M 8 .   ? -13.679 -49.496 -29.886 1.00 48.28  ? 1112 HOH A O   1 
HETATM 4833 O  O   . HOH M 8 .   ? -29.328 -56.304 -36.439 1.00 48.00  ? 1113 HOH A O   1 
HETATM 4834 O  O   . HOH M 8 .   ? -13.981 -45.067 -3.751  1.00 68.23  ? 1114 HOH A O   1 
HETATM 4835 O  O   . HOH M 8 .   ? 5.832   -44.977 -36.065 1.00 43.45  ? 1115 HOH A O   1 
HETATM 4836 O  O   . HOH M 8 .   ? -42.334 -63.454 -18.463 1.00 56.13  ? 1116 HOH A O   1 
HETATM 4837 O  O   . HOH M 8 .   ? -35.686 -57.275 -30.210 1.00 61.40  ? 1117 HOH A O   1 
HETATM 4838 O  O   . HOH M 8 .   ? 0.228   -64.948 -19.284 1.00 44.80  ? 1118 HOH A O   1 
HETATM 4839 O  O   . HOH M 8 .   ? -15.086 -54.734 -39.574 1.00 39.71  ? 1119 HOH A O   1 
HETATM 4840 O  O   . HOH M 8 .   ? -38.344 -67.692 -8.424  1.00 39.46  ? 1120 HOH A O   1 
HETATM 4841 O  O   . HOH M 8 .   ? -4.281  -54.689 -11.938 1.00 55.13  ? 1121 HOH A O   1 
HETATM 4842 O  O   . HOH M 8 .   ? -27.072 -65.997 -39.992 1.00 47.76  ? 1122 HOH A O   1 
HETATM 4843 O  O   . HOH M 8 .   ? -9.092  -37.189 -19.856 1.00 46.54  ? 1123 HOH A O   1 
HETATM 4844 O  O   . HOH M 8 .   ? -27.516 -9.492  -30.235 1.00 62.46  ? 1124 HOH A O   1 
HETATM 4845 O  O   . HOH M 8 .   ? -7.673  -42.954 -42.888 1.00 49.38  ? 1125 HOH A O   1 
HETATM 4846 O  O   . HOH M 8 .   ? -9.920  -64.612 -33.193 1.00 52.95  ? 1126 HOH A O   1 
HETATM 4847 O  O   . HOH M 8 .   ? -7.090  -20.538 -27.197 1.00 39.15  ? 1127 HOH A O   1 
HETATM 4848 O  O   . HOH M 8 .   ? -16.366 -12.067 -29.513 1.00 55.09  ? 1128 HOH A O   1 
HETATM 4849 O  O   . HOH M 8 .   ? -16.236 -11.275 -22.634 1.00 66.23  ? 1129 HOH A O   1 
HETATM 4850 O  O   . HOH M 8 .   ? -23.165 -65.328 -38.908 1.00 47.63  ? 1130 HOH A O   1 
HETATM 4851 O  O   . HOH M 8 .   ? -29.868 -50.632 -27.218 1.00 44.13  ? 1131 HOH A O   1 
HETATM 4852 O  O   . HOH M 8 .   ? -28.601 -69.902 -14.194 1.00 47.92  ? 1132 HOH A O   1 
HETATM 4853 O  O   . HOH M 8 .   ? -21.083 -47.355 -9.985  1.00 50.16  ? 1133 HOH A O   1 
HETATM 4854 O  O   . HOH M 8 .   ? 1.037   -21.754 -45.614 1.00 53.80  ? 1134 HOH A O   1 
HETATM 4855 O  O   . HOH M 8 .   ? -6.594  -11.932 -22.344 1.00 63.22  ? 1135 HOH A O   1 
HETATM 4856 O  O   . HOH M 8 .   ? 11.355  -34.560 -33.169 1.00 40.75  ? 1136 HOH A O   1 
HETATM 4857 O  O   . HOH M 8 .   ? -4.310  -53.891 -28.085 1.00 29.28  ? 1137 HOH A O   1 
HETATM 4858 O  O   . HOH M 8 .   ? -35.090 -50.579 -12.924 1.00 40.52  ? 1138 HOH A O   1 
HETATM 4859 O  O   . HOH M 8 .   ? 1.410   -32.613 -38.950 1.00 27.39  ? 1139 HOH A O   1 
HETATM 4860 O  O   . HOH M 8 .   ? -16.708 -32.487 -18.281 1.00 47.79  ? 1140 HOH A O   1 
HETATM 4861 O  O   . HOH M 8 .   ? -31.879 -57.613 -21.760 1.00 32.44  ? 1141 HOH A O   1 
HETATM 4862 O  O   . HOH M 8 .   ? 4.724   -16.597 -21.890 1.00 59.54  ? 1142 HOH A O   1 
HETATM 4863 O  O   . HOH M 8 .   ? -24.152 -69.801 -27.779 1.00 39.50  ? 1143 HOH A O   1 
HETATM 4864 O  O   . HOH M 8 .   ? -36.847 -50.563 -5.410  1.00 34.05  ? 1144 HOH A O   1 
HETATM 4865 O  O   . HOH M 8 .   ? -0.018  -31.345 -23.175 1.00 31.52  ? 1145 HOH A O   1 
HETATM 4866 O  O   . HOH M 8 .   ? -23.719 -46.618 -36.843 1.00 57.19  ? 1146 HOH A O   1 
HETATM 4867 O  O   . HOH M 8 .   ? -38.262 -38.087 -26.418 1.00 55.50  ? 1147 HOH A O   1 
HETATM 4868 O  O   . HOH M 8 .   ? 3.015   -51.504 -26.937 1.00 32.74  ? 1148 HOH A O   1 
HETATM 4869 O  O   . HOH M 8 .   ? -3.854  -61.804 -15.490 1.00 32.39  ? 1149 HOH A O   1 
HETATM 4870 O  O   . HOH M 8 .   ? -39.735 -64.373 -19.531 1.00 57.21  ? 1150 HOH A O   1 
HETATM 4871 O  O   . HOH M 8 .   ? 2.681   -39.732 -27.088 1.00 33.83  ? 1151 HOH A O   1 
HETATM 4872 O  O   . HOH M 8 .   ? 6.012   -31.585 -19.530 1.00 41.91  ? 1152 HOH A O   1 
HETATM 4873 O  O   . HOH M 8 .   ? -17.523 -42.001 -37.146 1.00 46.99  ? 1153 HOH A O   1 
HETATM 4874 O  O   . HOH M 8 .   ? -14.936 -35.031 -29.082 1.00 23.34  ? 1154 HOH A O   1 
HETATM 4875 O  O   . HOH M 8 .   ? -13.755 -74.574 -14.079 1.00 39.27  ? 1155 HOH A O   1 
HETATM 4876 O  O   . HOH M 8 .   ? 10.395  -38.756 -29.961 1.00 51.17  ? 1156 HOH A O   1 
HETATM 4877 O  O   . HOH M 8 .   ? 5.501   -30.205 -21.775 1.00 34.11  ? 1157 HOH A O   1 
HETATM 4878 O  O   . HOH M 8 .   ? 0.142   -33.086 -27.972 1.00 27.74  ? 1158 HOH A O   1 
HETATM 4879 O  O   . HOH M 8 .   ? -12.822 -43.037 -39.071 1.00 38.08  ? 1159 HOH A O   1 
HETATM 4880 O  O   . HOH M 8 .   ? -40.540 -57.922 -6.337  1.00 47.99  ? 1160 HOH A O   1 
HETATM 4881 O  O   . HOH M 8 .   ? -8.394  -65.026 -7.066  1.00 28.86  ? 1161 HOH A O   1 
HETATM 4882 O  O   . HOH M 8 .   ? 6.567   -35.416 -43.919 1.00 47.18  ? 1162 HOH A O   1 
HETATM 4883 O  O   . HOH M 8 .   ? 2.572   -44.437 -41.249 1.00 44.92  ? 1163 HOH A O   1 
HETATM 4884 O  O   . HOH M 8 .   ? -13.497 -13.032 -27.272 1.00 51.01  ? 1164 HOH A O   1 
HETATM 4885 O  O   . HOH M 8 .   ? -40.304 -61.479 -11.396 1.00 25.85  ? 1165 HOH A O   1 
HETATM 4886 O  O   . HOH M 8 .   ? -3.830  -15.508 -20.678 1.00 49.80  ? 1166 HOH A O   1 
HETATM 4887 O  O   . HOH M 8 .   ? -15.524 -22.158 -19.067 1.00 38.62  ? 1167 HOH A O   1 
HETATM 4888 O  O   . HOH M 8 .   ? 9.991   -25.729 -32.603 1.00 52.27  ? 1168 HOH A O   1 
HETATM 4889 O  O   . HOH M 8 .   ? -7.402  -47.468 -18.199 1.00 33.91  ? 1169 HOH A O   1 
HETATM 4890 O  O   . HOH M 8 .   ? -32.771 -63.755 -15.126 1.00 28.03  ? 1170 HOH A O   1 
HETATM 4891 O  O   . HOH M 8 .   ? -5.079  -15.800 -28.391 1.00 48.56  ? 1171 HOH A O   1 
HETATM 4892 O  O   . HOH M 8 .   ? 2.776   -64.778 -20.795 1.00 23.23  ? 1172 HOH A O   1 
HETATM 4893 O  O   . HOH M 8 .   ? -4.023  -57.585 -9.719  1.00 33.18  ? 1173 HOH A O   1 
HETATM 4894 O  O   . HOH M 8 .   ? -2.342  -55.769 -31.431 1.00 49.36  ? 1174 HOH A O   1 
HETATM 4895 O  O   . HOH M 8 .   ? -22.724 -75.471 -8.699  0.50 33.08  ? 1175 HOH A O   1 
HETATM 4896 O  O   . HOH M 8 .   ? -28.127 -18.601 -35.190 1.00 53.00  ? 1176 HOH A O   1 
HETATM 4897 O  O   . HOH M 8 .   ? -42.358 -63.215 -5.164  1.00 42.27  ? 1177 HOH A O   1 
HETATM 4898 O  O   . HOH M 8 .   ? -26.710 -25.811 -33.481 1.00 31.50  ? 1178 HOH A O   1 
HETATM 4899 O  O   . HOH M 8 .   ? -21.558 -49.781 -34.987 1.00 46.57  ? 1179 HOH A O   1 
HETATM 4900 O  O   . HOH M 8 .   ? -29.350 -50.869 -30.058 1.00 53.71  ? 1180 HOH A O   1 
HETATM 4901 O  O   . HOH M 8 .   ? 5.787   -32.986 -37.885 1.00 40.69  ? 1181 HOH A O   1 
HETATM 4902 O  O   . HOH M 8 .   ? -10.910 -62.576 -18.801 1.00 18.68  ? 1182 HOH A O   1 
HETATM 4903 O  O   . HOH M 8 .   ? -14.714 -64.277 -0.462  1.00 26.03  ? 1183 HOH A O   1 
HETATM 4904 O  O   . HOH M 8 .   ? -39.954 -24.304 -26.580 1.00 47.89  ? 1184 HOH A O   1 
HETATM 4905 O  O   . HOH M 8 .   ? -23.188 -27.698 -24.874 1.00 45.83  ? 1185 HOH A O   1 
HETATM 4906 O  O   . HOH M 8 .   ? -8.967  -26.599 -44.662 1.00 37.77  ? 1186 HOH A O   1 
HETATM 4907 O  O   . HOH M 8 .   ? -20.893 -19.697 -38.885 1.00 57.71  ? 1187 HOH A O   1 
HETATM 4908 O  O   . HOH M 8 .   ? -29.592 -33.822 -28.713 1.00 55.05  ? 1188 HOH A O   1 
HETATM 4909 O  O   . HOH M 8 .   ? -19.956 -76.442 -14.106 1.00 56.65  ? 1189 HOH A O   1 
HETATM 4910 O  O   . HOH M 8 .   ? -8.897  -64.101 -31.019 1.00 46.18  ? 1190 HOH A O   1 
HETATM 4911 O  O   . HOH M 8 .   ? -35.540 -66.893 -0.713  1.00 35.19  ? 1191 HOH A O   1 
HETATM 4912 O  O   . HOH M 8 .   ? -38.792 -61.052 -4.300  1.00 34.45  ? 1192 HOH A O   1 
HETATM 4913 O  O   . HOH M 8 .   ? -12.424 -58.409 -0.000  0.50 24.73  ? 1193 HOH A O   1 
HETATM 4914 O  O   . HOH M 8 .   ? 0.140   -68.300 -19.086 0.48 40.44  ? 1194 HOH A O   1 
HETATM 4915 O  O   . HOH M 8 .   ? -1.611  -41.750 -21.350 1.00 58.32  ? 1195 HOH A O   1 
HETATM 4916 O  O   . HOH M 8 .   ? -1.100  -68.721 -21.414 1.00 53.69  ? 1196 HOH A O   1 
HETATM 4917 O  O   . HOH M 8 .   ? -13.955 -32.846 -44.964 0.50 51.26  ? 1197 HOH A O   1 
HETATM 4918 O  O   . HOH M 8 .   ? -17.144 -35.199 -42.288 0.50 40.16  ? 1198 HOH A O   1 
HETATM 4919 O  O   . HOH M 8 .   ? 7.862   -43.108 -36.343 1.00 48.95  ? 1199 HOH A O   1 
HETATM 4920 O  O   . HOH M 8 .   ? -18.013 -62.382 -3.023  1.00 23.64  ? 1200 HOH A O   1 
HETATM 4921 O  O   . HOH M 8 .   ? -29.305 -63.714 -34.649 1.00 52.30  ? 1201 HOH A O   1 
HETATM 4922 O  O   . HOH M 8 .   ? -15.317 -66.122 -33.918 1.00 44.12  ? 1202 HOH A O   1 
HETATM 4923 O  O   . HOH M 8 .   ? -26.265 -50.997 -3.366  0.50 34.99  ? 1203 HOH A O   1 
HETATM 4924 O  O   . HOH M 8 .   ? -19.688 -27.581 -40.228 1.00 32.94  ? 1204 HOH A O   1 
HETATM 4925 O  O   . HOH M 8 .   ? -10.953 -48.546 -39.223 1.00 27.16  ? 1205 HOH A O   1 
HETATM 4926 O  O   . HOH M 8 .   ? -20.691 -29.387 -25.094 1.00 43.66  ? 1206 HOH A O   1 
HETATM 4927 O  O   . HOH M 8 .   ? -28.500 -68.195 -30.019 1.00 57.31  ? 1207 HOH A O   1 
HETATM 4928 O  O   . HOH M 8 .   ? -12.372 -37.153 -39.630 1.00 31.25  ? 1208 HOH A O   1 
HETATM 4929 O  O   . HOH M 8 .   ? -28.485 -50.182 0.189   1.00 32.27  ? 1209 HOH A O   1 
HETATM 4930 O  O   . HOH M 8 .   ? -17.589 -31.459 -41.907 1.00 55.47  ? 1210 HOH A O   1 
HETATM 4931 O  O   . HOH M 8 .   ? -14.919 -17.434 -36.274 1.00 44.90  ? 1211 HOH A O   1 
HETATM 4932 O  O   . HOH M 8 .   ? 10.529  -27.203 -29.278 1.00 46.53  ? 1212 HOH A O   1 
HETATM 4933 O  O   . HOH M 8 .   ? -3.388  -20.346 -23.600 1.00 37.13  ? 1213 HOH A O   1 
HETATM 4934 O  O   . HOH M 8 .   ? -13.011 -53.825 -40.524 1.00 51.07  ? 1214 HOH A O   1 
HETATM 4935 O  O   . HOH M 8 .   ? -19.365 -17.314 -11.216 1.00 50.33  ? 1215 HOH A O   1 
HETATM 4936 O  O   . HOH M 8 .   ? -2.143  -60.274 -31.612 1.00 64.85  ? 1216 HOH A O   1 
HETATM 4937 O  O   . HOH M 8 .   ? -30.258 -57.298 -34.359 1.00 35.27  ? 1217 HOH A O   1 
HETATM 4938 O  O   . HOH M 8 .   ? 5.614   -20.198 -43.477 1.00 55.20  ? 1218 HOH A O   1 
HETATM 4939 O  O   . HOH M 8 .   ? -22.549 -66.118 -23.680 1.00 36.84  ? 1219 HOH A O   1 
HETATM 4940 O  O   . HOH M 8 .   ? -18.849 -65.451 -7.167  1.00 19.17  ? 1220 HOH A O   1 
HETATM 4941 O  O   . HOH M 8 .   ? -5.232  -48.914 -28.747 1.00 29.48  ? 1221 HOH A O   1 
HETATM 4942 O  O   . HOH M 8 .   ? -4.387  -65.718 -15.237 1.00 35.14  ? 1222 HOH A O   1 
HETATM 4943 O  O   . HOH M 8 .   ? -19.381 -20.920 -40.651 1.00 40.23  ? 1223 HOH A O   1 
HETATM 4944 O  O   . HOH M 8 .   ? -5.727  -59.373 -12.166 1.00 40.65  ? 1224 HOH A O   1 
HETATM 4945 O  O   . HOH M 8 .   ? -17.565 -62.132 -44.804 1.00 56.61  ? 1225 HOH A O   1 
HETATM 4946 O  O   . HOH M 8 .   ? -9.039  -59.261 -13.331 1.00 25.84  ? 1226 HOH A O   1 
HETATM 4947 O  O   . HOH M 8 .   ? -9.122  -40.113 -39.814 1.00 50.89  ? 1227 HOH A O   1 
HETATM 4948 O  O   . HOH M 8 .   ? -32.546 -49.203 -18.982 1.00 44.92  ? 1228 HOH A O   1 
HETATM 4949 O  O   . HOH M 8 .   ? -29.195 -17.938 -20.976 1.00 51.56  ? 1229 HOH A O   1 
HETATM 4950 O  O   . HOH M 8 .   ? -22.543 -51.292 -9.211  1.00 28.83  ? 1230 HOH A O   1 
HETATM 4951 O  O   . HOH M 8 .   ? 4.107   -26.854 -29.696 1.00 39.22  ? 1231 HOH A O   1 
HETATM 4952 O  O   . HOH M 8 .   ? -0.873  -11.304 -30.548 1.00 51.35  ? 1232 HOH A O   1 
HETATM 4953 O  O   . HOH M 8 .   ? -39.619 -55.507 -6.319  1.00 37.22  ? 1233 HOH A O   1 
HETATM 4954 O  O   . HOH M 8 .   ? -41.235 -58.409 -9.946  0.50 29.86  ? 1234 HOH A O   1 
HETATM 4955 O  O   . HOH M 8 .   ? -21.688 -66.331 -4.500  1.00 36.60  ? 1235 HOH A O   1 
HETATM 4956 O  O   . HOH M 8 .   ? -31.769 -60.322 -15.896 1.00 30.87  ? 1236 HOH A O   1 
HETATM 4957 O  O   . HOH M 8 .   ? -9.484  -21.633 -27.342 1.00 37.36  ? 1237 HOH A O   1 
HETATM 4958 O  O   . HOH M 8 .   ? -20.956 -65.562 -40.998 1.00 41.83  ? 1238 HOH A O   1 
HETATM 4959 O  O   . HOH M 8 .   ? -4.732  -62.707 -4.590  1.00 38.91  ? 1239 HOH A O   1 
HETATM 4960 O  O   . HOH M 8 .   ? -5.462  -60.516 -0.720  1.00 34.05  ? 1240 HOH A O   1 
HETATM 4961 O  O   . HOH M 8 .   ? -24.826 -14.666 -4.810  1.00 49.78  ? 1241 HOH A O   1 
HETATM 4962 O  O   . HOH M 8 .   ? -22.252 -74.501 -11.595 1.00 28.78  ? 1242 HOH A O   1 
HETATM 4963 O  O   . HOH M 8 .   ? 10.426  -29.950 -34.323 1.00 46.14  ? 1243 HOH A O   1 
HETATM 4964 O  O   . HOH M 8 .   ? -26.559 -71.488 -3.559  1.00 37.50  ? 1244 HOH A O   1 
HETATM 4965 O  O   . HOH M 8 .   ? -0.109  -55.491 -33.190 1.00 55.40  ? 1245 HOH A O   1 
HETATM 4966 O  O   . HOH M 8 .   ? -3.092  -55.373 -18.065 1.00 26.73  ? 1246 HOH A O   1 
HETATM 4967 O  O   . HOH M 8 .   ? -38.476 -61.163 -14.338 1.00 32.54  ? 1247 HOH A O   1 
HETATM 4968 O  O   . HOH M 8 .   ? -26.540 -30.845 -23.485 1.00 49.03  ? 1248 HOH A O   1 
HETATM 4969 O  O   . HOH M 8 .   ? -24.622 -69.976 -34.348 1.00 60.28  ? 1249 HOH A O   1 
HETATM 4970 O  O   . HOH M 8 .   ? -28.066 -47.442 0.032   1.00 43.56  ? 1250 HOH A O   1 
HETATM 4971 O  O   . HOH M 8 .   ? -22.077 -31.578 -39.835 1.00 42.01  ? 1251 HOH A O   1 
HETATM 4972 O  O   . HOH M 8 .   ? -24.894 -22.670 -40.849 0.50 42.20  ? 1252 HOH A O   1 
HETATM 4973 O  O   . HOH M 8 .   ? 4.068   -29.008 -44.441 1.00 40.78  ? 1253 HOH A O   1 
HETATM 4974 O  O   . HOH M 8 .   ? -7.703  -61.972 -34.321 0.48 42.19  ? 1254 HOH A O   1 
HETATM 4975 O  O   . HOH M 8 .   ? -38.887 -57.306 -20.362 1.00 41.74  ? 1255 HOH A O   1 
HETATM 4976 O  O   . HOH M 8 .   ? -27.410 -52.717 -42.100 1.00 47.69  ? 1256 HOH A O   1 
HETATM 4977 O  O   . HOH M 8 .   ? 8.111   -45.396 -28.974 0.50 43.73  ? 1257 HOH A O   1 
HETATM 4978 O  O   . HOH M 8 .   ? -7.046  -50.065 -6.720  1.00 49.06  ? 1258 HOH A O   1 
HETATM 4979 O  O   . HOH M 8 .   ? -38.782 -55.183 -18.980 1.00 36.53  ? 1259 HOH A O   1 
HETATM 4980 O  O   . HOH M 8 .   ? 5.789   -38.960 -24.343 1.00 43.72  ? 1260 HOH A O   1 
HETATM 4981 O  O   . HOH M 8 .   ? 1.109   -41.872 -24.540 1.00 40.91  ? 1261 HOH A O   1 
HETATM 4982 O  O   . HOH M 8 .   ? 7.732   -22.233 -24.714 1.00 46.69  ? 1262 HOH A O   1 
HETATM 4983 O  O   . HOH M 8 .   ? -34.802 -63.003 0.699   1.00 25.24  ? 1263 HOH A O   1 
HETATM 4984 O  O   . HOH M 8 .   ? -23.161 -33.754 -36.887 1.00 33.34  ? 1264 HOH A O   1 
HETATM 4985 O  O   . HOH M 8 .   ? -17.876 -66.204 -36.307 1.00 49.12  ? 1265 HOH A O   1 
HETATM 4986 O  O   . HOH M 8 .   ? 8.778   -40.439 -32.014 1.00 52.14  ? 1266 HOH A O   1 
HETATM 4987 O  O   . HOH M 8 .   ? -29.869 -59.780 -19.686 1.00 34.78  ? 1267 HOH A O   1 
HETATM 4988 O  O   . HOH M 8 .   ? -28.143 -17.146 -32.388 1.00 40.27  ? 1268 HOH A O   1 
HETATM 4989 O  O   . HOH M 8 .   ? -20.566 -67.542 -25.317 1.00 28.98  ? 1269 HOH A O   1 
HETATM 4990 O  O   . HOH M 8 .   ? 7.263   -49.693 -30.688 1.00 53.48  ? 1270 HOH A O   1 
HETATM 4991 O  O   . HOH M 8 .   ? -30.129 -60.967 -23.071 1.00 31.42  ? 1271 HOH A O   1 
HETATM 4992 O  O   . HOH M 8 .   ? -27.238 -57.292 -40.061 1.00 42.98  ? 1272 HOH A O   1 
HETATM 4993 O  O   . HOH M 8 .   ? -27.961 -23.232 -26.561 1.00 33.37  ? 1273 HOH A O   1 
HETATM 4994 O  O   . HOH M 8 .   ? -10.561 -41.731 -38.068 1.00 46.82  ? 1274 HOH A O   1 
HETATM 4995 O  O   . HOH M 8 .   ? -13.971 -49.899 -32.121 1.00 32.82  ? 1275 HOH A O   1 
HETATM 4996 O  O   . HOH M 8 .   ? 8.743   -24.327 -36.230 1.00 50.74  ? 1276 HOH A O   1 
HETATM 4997 O  O   . HOH M 8 .   ? 4.938   -37.016 -23.791 1.00 45.46  ? 1277 HOH A O   1 
HETATM 4998 O  O   . HOH M 8 .   ? -5.067  -34.724 -20.936 1.00 48.44  ? 1278 HOH A O   1 
HETATM 4999 O  O   . HOH M 8 .   ? -13.255 -68.825 -6.162  1.00 36.12  ? 1279 HOH A O   1 
HETATM 5000 O  O   . HOH M 8 .   ? -19.137 -68.570 -1.875  1.00 38.87  ? 1280 HOH A O   1 
HETATM 5001 O  O   . HOH M 8 .   ? -5.813  -50.540 -18.726 1.00 32.36  ? 1281 HOH A O   1 
HETATM 5002 O  O   . HOH M 8 .   ? -34.796 -59.837 -29.599 1.00 51.08  ? 1282 HOH A O   1 
HETATM 5003 O  O   . HOH M 8 .   ? -23.350 -50.051 -42.156 1.00 41.69  ? 1283 HOH A O   1 
HETATM 5004 O  O   . HOH M 8 .   ? -24.455 -69.047 -38.190 1.00 49.17  ? 1284 HOH A O   1 
HETATM 5005 O  O   . HOH M 8 .   ? -20.637 -66.386 -1.276  1.00 36.69  ? 1285 HOH A O   1 
HETATM 5006 O  O   . HOH M 8 .   ? -14.140 -52.468 -5.880  1.00 26.41  ? 1286 HOH A O   1 
HETATM 5007 O  O   . HOH M 8 .   ? -27.893 -40.572 -5.410  1.00 63.31  ? 1287 HOH A O   1 
HETATM 5008 O  O   . HOH M 8 .   ? -5.662  -33.161 -17.732 1.00 41.37  ? 1288 HOH A O   1 
HETATM 5009 O  O   . HOH M 8 .   ? -14.294 -56.626 -1.524  1.00 20.99  ? 1289 HOH A O   1 
HETATM 5010 O  O   . HOH M 8 .   ? -23.163 -21.001 -37.985 1.00 48.43  ? 1290 HOH A O   1 
HETATM 5011 O  O   . HOH M 8 .   ? -17.051 -52.142 -15.575 1.00 21.19  ? 1291 HOH A O   1 
HETATM 5012 O  O   . HOH M 8 .   ? -19.132 -69.956 -8.122  1.00 26.79  ? 1292 HOH A O   1 
HETATM 5013 O  O   . HOH M 8 .   ? 6.572   -29.643 -44.014 1.00 44.61  ? 1293 HOH A O   1 
HETATM 5014 O  O   . HOH M 8 .   ? 0.509   -23.624 -17.115 1.00 53.16  ? 1294 HOH A O   1 
HETATM 5015 O  O   . HOH M 8 .   ? -25.054 -53.611 -1.933  1.00 26.12  ? 1295 HOH A O   1 
HETATM 5016 O  O   . HOH M 8 .   ? -28.970 -46.049 2.672   1.00 44.44  ? 1296 HOH A O   1 
HETATM 5017 O  O   . HOH M 8 .   ? -33.702 -57.682 -19.668 1.00 40.78  ? 1297 HOH A O   1 
HETATM 5018 O  O   . HOH M 8 .   ? 10.927  -40.920 -37.948 1.00 50.05  ? 1298 HOH A O   1 
HETATM 5019 O  O   . HOH M 8 .   ? -19.708 -43.913 -38.090 1.00 49.19  ? 1299 HOH A O   1 
HETATM 5020 O  O   . HOH M 8 .   ? 3.596   -43.430 -43.275 1.00 49.62  ? 1300 HOH A O   1 
HETATM 5021 O  O   . HOH M 8 .   ? -18.483 -76.319 -16.297 1.00 48.09  ? 1301 HOH A O   1 
HETATM 5022 O  O   . HOH M 8 .   ? -4.256  -23.387 -25.435 1.00 41.01  ? 1302 HOH A O   1 
HETATM 5023 O  O   . HOH M 8 .   ? -27.245 -26.826 -35.937 1.00 34.79  ? 1303 HOH A O   1 
HETATM 5024 O  O   . HOH M 8 .   ? -35.287 -59.553 -0.516  1.00 42.53  ? 1304 HOH A O   1 
HETATM 5025 O  O   . HOH M 8 .   ? -22.814 -27.794 -18.992 1.00 50.82  ? 1305 HOH A O   1 
HETATM 5026 O  O   . HOH M 8 .   ? -12.045 -39.993 -39.597 1.00 54.03  ? 1306 HOH A O   1 
HETATM 5027 O  O   . HOH M 8 .   ? -10.070 -75.481 -8.938  1.00 60.76  ? 1307 HOH A O   1 
HETATM 5028 O  O   . HOH M 8 .   ? -13.730 -53.849 -1.515  1.00 25.01  ? 1308 HOH A O   1 
HETATM 5029 O  O   . HOH M 8 .   ? -0.504  -35.829 -28.280 1.00 34.32  ? 1309 HOH A O   1 
HETATM 5030 O  O   . HOH M 8 .   ? -20.895 -31.983 -29.518 1.00 34.73  ? 1310 HOH A O   1 
HETATM 5031 O  O   . HOH M 8 .   ? -12.440 -67.236 -29.636 1.00 35.86  ? 1311 HOH A O   1 
HETATM 5032 O  O   . HOH M 8 .   ? -36.305 -58.459 -20.759 1.00 44.79  ? 1312 HOH A O   1 
HETATM 5033 O  O   . HOH M 8 .   ? -17.193 -29.050 -41.057 1.00 58.44  ? 1313 HOH A O   1 
HETATM 5034 O  O   . HOH M 8 .   ? -2.319  -39.892 -45.848 1.00 43.16  ? 1314 HOH A O   1 
HETATM 5035 O  O   . HOH M 8 .   ? -3.808  -71.141 -9.077  1.00 38.97  ? 1315 HOH A O   1 
HETATM 5036 O  O   . HOH M 8 .   ? -34.033 -70.477 -18.301 1.00 39.20  ? 1316 HOH A O   1 
HETATM 5037 O  O   . HOH M 8 .   ? -24.097 -58.360 -46.660 1.00 46.02  ? 1317 HOH A O   1 
HETATM 5038 O  O   . HOH M 8 .   ? -7.360  -57.741 -1.124  1.00 43.30  ? 1318 HOH A O   1 
HETATM 5039 O  O   . HOH M 8 .   ? -39.916 -54.913 -14.704 1.00 39.57  ? 1319 HOH A O   1 
HETATM 5040 O  O   . HOH M 8 .   ? -5.919  -49.283 -21.300 1.00 29.47  ? 1320 HOH A O   1 
HETATM 5041 O  O   . HOH M 8 .   ? -6.401  -43.321 -21.238 1.00 48.86  ? 1321 HOH A O   1 
HETATM 5042 O  O   . HOH M 8 .   ? -20.161 -38.182 -36.726 1.00 34.71  ? 1322 HOH A O   1 
HETATM 5043 O  O   . HOH M 8 .   ? -15.073 -48.780 -18.759 1.00 34.03  ? 1323 HOH A O   1 
HETATM 5044 O  O   . HOH M 8 .   ? -33.789 -47.437 -15.607 1.00 47.98  ? 1324 HOH A O   1 
HETATM 5045 O  O   . HOH M 8 .   ? -35.834 -54.380 -3.205  1.00 30.03  ? 1325 HOH A O   1 
HETATM 5046 O  O   . HOH M 8 .   ? -39.814 -64.162 -2.309  1.00 42.85  ? 1326 HOH A O   1 
HETATM 5047 O  O   . HOH M 8 .   ? -31.211 -74.011 -18.236 1.00 55.32  ? 1327 HOH A O   1 
HETATM 5048 O  O   . HOH M 8 .   ? -4.829  -56.593 -31.646 1.00 28.91  ? 1328 HOH A O   1 
HETATM 5049 O  O   . HOH M 8 .   ? -20.194 -46.560 -25.453 1.00 37.03  ? 1329 HOH A O   1 
HETATM 5050 O  O   . HOH M 8 .   ? -5.354  -58.629 -30.007 1.00 36.50  ? 1330 HOH A O   1 
HETATM 5051 O  O   . HOH M 8 .   ? -29.919 -61.789 -33.193 1.00 45.70  ? 1331 HOH A O   1 
HETATM 5052 O  O   . HOH M 8 .   ? -2.569  -58.149 -27.531 1.00 27.39  ? 1332 HOH A O   1 
HETATM 5053 O  O   . HOH M 8 .   ? 9.786   -38.284 -39.392 1.00 46.67  ? 1333 HOH A O   1 
HETATM 5054 O  O   . HOH M 8 .   ? -6.553  -37.291 -20.716 1.00 51.41  ? 1334 HOH A O   1 
HETATM 5055 O  O   . HOH M 8 .   ? -32.002 -19.170 -31.064 1.00 53.05  ? 1335 HOH A O   1 
HETATM 5056 O  O   . HOH M 8 .   ? 1.236   -38.476 -21.156 1.00 58.73  ? 1336 HOH A O   1 
HETATM 5057 O  O   . HOH M 8 .   ? 3.395   -31.665 -37.429 1.00 31.06  ? 1337 HOH A O   1 
HETATM 5058 O  O   . HOH M 8 .   ? -28.298 -49.305 -31.600 1.00 47.99  ? 1338 HOH A O   1 
HETATM 5059 O  O   . HOH M 8 .   ? -15.535 -55.307 -43.670 1.00 49.80  ? 1339 HOH A O   1 
HETATM 5060 O  O   . HOH M 8 .   ? -9.218  -71.363 -15.347 0.48 30.00  ? 1340 HOH A O   1 
HETATM 5061 O  O   . HOH M 8 .   ? -8.643  -17.276 -39.529 1.00 42.75  ? 1341 HOH A O   1 
HETATM 5062 O  O   . HOH M 8 .   ? -22.614 -44.587 -33.226 0.50 36.22  ? 1342 HOH A O   1 
HETATM 5063 O  O   . HOH M 8 .   ? -31.329 -71.929 -13.592 1.00 57.47  ? 1343 HOH A O   1 
HETATM 5064 O  O   . HOH M 8 .   ? -35.396 -58.580 -27.774 1.00 56.29  ? 1344 HOH A O   1 
HETATM 5065 O  O   . HOH M 8 .   ? -15.909 -27.462 -46.078 1.00 57.37  ? 1345 HOH A O   1 
HETATM 5066 O  O   . HOH M 8 .   ? -14.767 -54.467 -4.104  1.00 24.19  ? 1346 HOH A O   1 
HETATM 5067 O  O   . HOH M 8 .   ? -3.784  -56.744 -7.100  1.00 30.96  ? 1347 HOH A O   1 
HETATM 5068 O  O   . HOH M 8 .   ? -23.642 -47.720 -33.591 0.50 35.81  ? 1348 HOH A O   1 
HETATM 5069 O  O   . HOH M 8 .   ? -37.563 -52.671 -13.020 1.00 27.51  ? 1349 HOH A O   1 
HETATM 5070 O  O   . HOH M 8 .   ? -20.332 -31.639 -26.754 1.00 34.58  ? 1350 HOH A O   1 
HETATM 5071 O  O   . HOH M 8 .   ? -7.512  -51.628 -10.374 1.00 52.56  ? 1351 HOH A O   1 
HETATM 5072 O  O   . HOH M 8 .   ? -14.814 -70.711 -18.887 1.00 41.50  ? 1352 HOH A O   1 
HETATM 5073 O  O   . HOH M 8 .   ? -7.815  -30.182 -46.216 1.00 41.19  ? 1353 HOH A O   1 
HETATM 5074 O  O   . HOH M 8 .   ? -11.721 -72.122 -15.626 1.00 27.42  ? 1354 HOH A O   1 
HETATM 5075 O  O   . HOH M 8 .   ? -4.405  -53.031 -38.567 1.00 54.75  ? 1355 HOH A O   1 
HETATM 5076 O  O   . HOH M 8 .   ? -18.218 -69.548 -24.731 1.00 38.18  ? 1356 HOH A O   1 
HETATM 5077 O  O   . HOH M 8 .   ? -10.142 -25.739 -12.437 1.00 49.26  ? 1357 HOH A O   1 
HETATM 5078 O  O   . HOH M 8 .   ? -4.173  -57.415 -13.550 1.00 42.60  ? 1358 HOH A O   1 
HETATM 5079 O  O   . HOH M 8 .   ? -37.514 -55.387 -24.637 1.00 56.33  ? 1359 HOH A O   1 
HETATM 5080 O  O   . HOH M 8 .   ? -12.174 -44.404 -16.468 1.00 47.23  ? 1360 HOH A O   1 
HETATM 5081 O  O   . HOH M 8 .   ? -17.528 -71.931 -22.872 1.00 45.63  ? 1361 HOH A O   1 
HETATM 5082 O  O   . HOH M 8 .   ? -28.670 -63.255 -25.348 1.00 36.07  ? 1362 HOH A O   1 
HETATM 5083 O  O   . HOH M 8 .   ? -24.796 -30.953 -39.997 1.00 52.44  ? 1363 HOH A O   1 
HETATM 5084 O  O   . HOH M 8 .   ? -3.022  -58.318 -24.658 1.00 22.25  ? 1364 HOH A O   1 
HETATM 5085 O  O   . HOH M 8 .   ? -31.404 -45.604 -15.592 1.00 49.52  ? 1365 HOH A O   1 
HETATM 5086 O  O   . HOH M 8 .   ? -11.197 -46.657 3.973   1.00 41.99  ? 1366 HOH A O   1 
HETATM 5087 O  O   . HOH M 8 .   ? -14.518 -21.185 -16.985 1.00 45.69  ? 1367 HOH A O   1 
HETATM 5088 O  O   . HOH M 8 .   ? -37.710 -68.595 -12.535 1.00 43.00  ? 1368 HOH A O   1 
HETATM 5089 O  O   . HOH M 8 .   ? -18.831 -49.769 -35.175 1.00 45.21  ? 1369 HOH A O   1 
HETATM 5090 O  O   . HOH M 8 .   ? -22.848 -37.692 -37.441 1.00 49.56  ? 1370 HOH A O   1 
HETATM 5091 O  O   . HOH M 8 .   ? -0.116  -48.237 -36.432 1.00 34.71  ? 1371 HOH A O   1 
HETATM 5092 O  O   . HOH M 8 .   ? -5.878  -69.155 -7.269  1.00 34.85  ? 1372 HOH A O   1 
HETATM 5093 O  O   . HOH M 8 .   ? -23.371 -45.548 -9.017  1.00 50.74  ? 1373 HOH A O   1 
HETATM 5094 O  O   . HOH M 8 .   ? -13.995 -51.196 -43.533 1.00 55.75  ? 1374 HOH A O   1 
HETATM 5095 O  O   . HOH M 8 .   ? -21.232 -43.787 -41.866 1.00 63.49  ? 1375 HOH A O   1 
HETATM 5096 O  O   . HOH M 8 .   ? -13.361 -11.610 -33.061 1.00 59.87  ? 1376 HOH A O   1 
HETATM 5097 O  O   . HOH M 8 .   ? -26.580 -27.914 -42.595 1.00 54.52  ? 1377 HOH A O   1 
HETATM 5098 O  O   . HOH M 8 .   ? 4.860   -69.391 -21.711 1.00 40.87  ? 1378 HOH A O   1 
HETATM 5099 O  O   . HOH M 8 .   ? -0.991  -32.555 -25.552 1.00 31.83  ? 1379 HOH A O   1 
HETATM 5100 O  O   . HOH M 8 .   ? -20.876 -75.737 -5.378  1.00 55.16  ? 1380 HOH A O   1 
HETATM 5101 O  O   . HOH M 8 .   ? 13.360  -30.693 -19.696 1.00 47.72  ? 1381 HOH A O   1 
HETATM 5102 O  O   . HOH M 8 .   ? -17.176 -57.874 -43.692 1.00 38.22  ? 1382 HOH A O   1 
HETATM 5103 O  O   . HOH M 8 .   ? -8.927  -35.891 -44.837 1.00 56.38  ? 1383 HOH A O   1 
HETATM 5104 O  O   . HOH M 8 .   ? -21.440 -41.712 -35.432 1.00 55.73  ? 1384 HOH A O   1 
HETATM 5105 O  O   . HOH M 8 .   ? -14.640 -70.356 -3.300  1.00 54.30  ? 1385 HOH A O   1 
HETATM 5106 O  O   . HOH M 8 .   ? -16.281 -49.436 -16.286 1.00 23.95  ? 1386 HOH A O   1 
HETATM 5107 O  O   . HOH M 8 .   ? -19.282 -64.811 -2.984  1.00 34.76  ? 1387 HOH A O   1 
HETATM 5108 O  O   . HOH M 8 .   ? -23.067 -63.364 -23.490 1.00 45.98  ? 1388 HOH A O   1 
HETATM 5109 O  O   . HOH M 8 .   ? 0.775   -31.509 -47.155 1.00 39.37  ? 1389 HOH A O   1 
HETATM 5110 O  O   . HOH M 8 .   ? -20.334 -70.923 -5.708  1.00 41.86  ? 1390 HOH A O   1 
HETATM 5111 O  O   . HOH M 8 .   ? -35.091 -67.888 -5.552  1.00 44.72  ? 1391 HOH A O   1 
HETATM 5112 O  O   . HOH M 8 .   ? -13.089 -32.863 -20.637 1.00 35.86  ? 1392 HOH A O   1 
HETATM 5113 O  O   . HOH M 8 .   ? 0.104   -45.756 -42.863 1.00 51.70  ? 1393 HOH A O   1 
HETATM 5114 O  O   . HOH M 8 .   ? -28.891 -70.108 -22.738 1.00 55.81  ? 1394 HOH A O   1 
HETATM 5115 O  O   . HOH M 8 .   ? -8.723  -31.137 -15.129 1.00 53.11  ? 1395 HOH A O   1 
HETATM 5116 O  O   . HOH M 8 .   ? -19.066 -45.555 -9.317  1.00 63.80  ? 1396 HOH A O   1 
HETATM 5117 O  O   . HOH M 8 .   ? -7.086  -61.064 -30.607 1.00 56.16  ? 1397 HOH A O   1 
HETATM 5118 O  O   . HOH M 8 .   ? -10.972 -70.423 -25.245 0.48 27.13  ? 1398 HOH A O   1 
HETATM 5119 O  O   . HOH M 8 .   ? -14.760 -57.325 -41.962 1.00 33.27  ? 1399 HOH A O   1 
HETATM 5120 O  O   . HOH M 8 .   ? -12.640 -37.957 -22.437 1.00 49.92  ? 1400 HOH A O   1 
HETATM 5121 O  O   . HOH M 8 .   ? -4.320  -34.586 -14.567 1.00 48.28  ? 1401 HOH A O   1 
HETATM 5122 O  O   . HOH M 8 .   ? -29.482 -69.238 -39.831 0.50 40.40  ? 1402 HOH A O   1 
HETATM 5123 O  O   . HOH M 8 .   ? -5.569  -59.062 -36.889 1.00 51.76  ? 1403 HOH A O   1 
HETATM 5124 O  O   . HOH M 8 .   ? -8.868  -71.847 -26.432 0.48 37.41  ? 1404 HOH A O   1 
HETATM 5125 O  O   . HOH M 8 .   ? -26.734 -68.018 -27.925 1.00 29.36  ? 1405 HOH A O   1 
HETATM 5126 O  O   . HOH M 8 .   ? -32.355 -14.167 -9.506  1.00 54.50  ? 1406 HOH A O   1 
HETATM 5127 O  O   . HOH M 8 .   ? -35.561 -50.972 -23.305 1.00 55.22  ? 1407 HOH A O   1 
HETATM 5128 O  O   . HOH M 8 .   ? -38.321 -28.332 -27.075 1.00 55.42  ? 1408 HOH A O   1 
HETATM 5129 O  O   . HOH M 8 .   ? 3.548   -34.076 -14.228 1.00 56.73  ? 1409 HOH A O   1 
HETATM 5130 O  O   . HOH M 8 .   ? 11.466  -37.607 -19.441 1.00 60.07  ? 1410 HOH A O   1 
HETATM 5131 O  O   . HOH M 8 .   ? -12.760 -41.629 -21.139 0.50 49.40  ? 1411 HOH A O   1 
HETATM 5132 O  O   . HOH M 8 .   ? -2.856  -55.904 -28.838 1.00 28.35  ? 1412 HOH A O   1 
HETATM 5133 O  O   . HOH M 8 .   ? 0.401   -45.839 -36.982 1.00 48.83  ? 1413 HOH A O   1 
HETATM 5134 O  O   . HOH M 8 .   ? -3.140  -72.661 -6.750  1.00 64.33  ? 1414 HOH A O   1 
HETATM 5135 O  O   . HOH M 8 .   ? -10.718 -17.839 -40.718 1.00 48.38  ? 1415 HOH A O   1 
HETATM 5136 O  O   . HOH M 8 .   ? -12.470 -75.859 -26.734 1.00 60.69  ? 1416 HOH A O   1 
HETATM 5137 O  O   . HOH M 8 .   ? -5.588  -31.185 -47.912 1.00 61.17  ? 1417 HOH A O   1 
HETATM 5138 O  O   . HOH M 8 .   ? -17.812 -47.425 -15.311 1.00 41.54  ? 1418 HOH A O   1 
HETATM 5139 O  O   . HOH M 8 .   ? -25.796 -20.379 -39.267 1.00 58.65  ? 1419 HOH A O   1 
HETATM 5140 O  O   . HOH M 8 .   ? -40.998 -25.468 -17.600 1.00 60.64  ? 1420 HOH A O   1 
HETATM 5141 O  O   . HOH M 8 .   ? -36.619 -65.009 0.106   1.00 44.45  ? 1421 HOH A O   1 
HETATM 5142 O  O   . HOH M 8 .   ? -23.244 -37.216 -32.861 1.00 49.92  ? 1422 HOH A O   1 
HETATM 5143 O  O   . HOH M 8 .   ? -33.705 -70.557 -14.401 1.00 60.47  ? 1423 HOH A O   1 
HETATM 5144 O  O   . HOH M 8 .   ? -34.078 -49.661 -10.384 1.00 42.77  ? 1424 HOH A O   1 
HETATM 5145 O  O   . HOH M 8 .   ? -30.864 -16.908 -32.041 1.00 48.25  ? 1425 HOH A O   1 
HETATM 5146 O  O   . HOH M 8 .   ? -36.529 -61.227 -20.594 1.00 58.90  ? 1426 HOH A O   1 
HETATM 5147 O  O   . HOH M 8 .   ? -5.724  -40.204 -45.780 1.00 65.21  ? 1427 HOH A O   1 
HETATM 5148 O  O   . HOH M 8 .   ? -3.418  -52.122 2.623   1.00 60.70  ? 1428 HOH A O   1 
HETATM 5149 O  O   . HOH M 8 .   ? -13.237 -45.543 -9.925  1.00 60.36  ? 1429 HOH A O   1 
HETATM 5150 O  O   . HOH M 8 .   ? -7.285  -30.090 -13.496 1.00 56.14  ? 1430 HOH A O   1 
HETATM 5151 O  O   . HOH M 8 .   ? 4.462   -62.690 -20.224 1.00 23.63  ? 1431 HOH A O   1 
HETATM 5152 O  O   . HOH M 8 .   ? -37.664 -60.771 -0.462  1.00 56.10  ? 1432 HOH A O   1 
HETATM 5153 O  O   . HOH M 8 .   ? -8.949  -55.758 -41.601 1.00 60.61  ? 1433 HOH A O   1 
HETATM 5154 O  O   . HOH M 8 .   ? -34.644 -70.240 -9.296  1.00 51.15  ? 1434 HOH A O   1 
HETATM 5155 O  O   . HOH M 8 .   ? 0.000   -58.408 -16.335 0.50 58.01  ? 1435 HOH A O   1 
HETATM 5156 O  O   . HOH M 8 .   ? -27.148 -74.063 -4.771  1.00 43.53  ? 1436 HOH A O   1 
HETATM 5157 O  O   . HOH M 8 .   ? -3.169  -51.969 -15.606 1.00 59.86  ? 1437 HOH A O   1 
HETATM 5158 O  O   . HOH M 8 .   ? -17.833 -28.215 -44.736 1.00 49.10  ? 1438 HOH A O   1 
HETATM 5159 O  O   . HOH M 8 .   ? -30.408 -63.529 -36.607 1.00 62.41  ? 1439 HOH A O   1 
HETATM 5160 O  O   . HOH M 8 .   ? -37.886 -52.485 -4.074  1.00 41.99  ? 1440 HOH A O   1 
HETATM 5161 O  O   . HOH M 8 .   ? -12.860 -22.110 15.294  1.00 62.53  ? 1441 HOH A O   1 
HETATM 5162 O  O   . HOH M 8 .   ? -30.196 -33.822 -32.988 1.00 60.27  ? 1442 HOH A O   1 
HETATM 5163 O  O   . HOH M 8 .   ? -22.771 -40.006 -2.018  0.50 54.52  ? 1443 HOH A O   1 
HETATM 5164 O  O   . HOH M 8 .   ? -8.993  -62.849 -41.762 1.00 59.34  ? 1444 HOH A O   1 
HETATM 5165 O  O   . HOH M 8 .   ? -19.821 -58.590 -48.405 1.00 69.70  ? 1445 HOH A O   1 
HETATM 5166 O  O   . HOH M 8 .   ? -15.455 -45.766 -19.402 1.00 53.01  ? 1446 HOH A O   1 
HETATM 5167 O  O   . HOH M 8 .   ? -12.238 -72.857 -24.861 0.48 47.19  ? 1447 HOH A O   1 
HETATM 5168 O  O   . HOH M 8 .   ? -19.043 -39.865 -38.581 1.00 47.03  ? 1448 HOH A O   1 
HETATM 5169 O  O   . HOH M 8 .   ? -25.299 -20.817 -5.004  1.00 53.48  ? 1449 HOH A O   1 
HETATM 5170 O  O   . HOH M 8 .   ? -38.885 -51.718 -20.180 1.00 57.27  ? 1450 HOH A O   1 
HETATM 5171 O  O   . HOH M 8 .   ? -15.786 -69.428 -5.951  1.00 25.94  ? 1451 HOH A O   1 
HETATM 5172 O  O   . HOH M 8 .   ? -10.400 -28.034 -12.055 1.00 52.92  ? 1452 HOH A O   1 
HETATM 5173 O  O   . HOH M 8 .   ? -1.619  -65.398 -15.902 1.00 59.99  ? 1453 HOH A O   1 
HETATM 5174 O  O   . HOH M 8 .   ? 0.430   -70.969 -21.352 1.00 40.48  ? 1454 HOH A O   1 
HETATM 5175 O  O   . HOH M 8 .   ? -35.942 -57.211 -4.196  1.00 57.69  ? 1455 HOH A O   1 
HETATM 5176 O  O   . HOH M 8 .   ? -34.789 -49.746 -20.832 1.00 57.84  ? 1456 HOH A O   1 
HETATM 5177 O  O   . HOH M 8 .   ? -39.962 -50.417 -9.946  1.00 59.49  ? 1457 HOH A O   1 
HETATM 5178 O  O   . HOH M 8 .   ? 0.000   -58.409 -28.490 0.50 29.02  ? 1458 HOH A O   1 
HETATM 5179 O  O   . HOH M 8 .   ? -8.109  -76.100 -10.741 1.00 61.37  ? 1459 HOH A O   1 
HETATM 5180 O  O   . HOH M 8 .   ? -40.563 -62.160 -3.205  1.00 67.18  ? 1460 HOH A O   1 
HETATM 5181 O  O   . HOH M 8 .   ? -13.301 -70.267 -23.017 0.48 37.53  ? 1461 HOH A O   1 
HETATM 5182 O  O   . HOH M 8 .   ? -16.727 -39.238 -39.932 1.00 54.42  ? 1462 HOH A O   1 
HETATM 5183 O  O   . HOH M 8 .   ? -25.068 -28.798 -22.738 1.00 52.14  ? 1463 HOH A O   1 
HETATM 5184 O  O   . HOH M 8 .   ? -25.745 -76.300 -8.865  1.00 63.25  ? 1464 HOH A O   1 
HETATM 5185 O  O   . HOH M 8 .   ? 5.036   -42.554 -16.773 0.48 50.22  ? 1465 HOH A O   1 
HETATM 5186 O  O   . HOH M 8 .   ? -2.994  -52.597 -4.567  1.00 67.05  ? 1466 HOH A O   1 
HETATM 5187 O  O   . HOH M 8 .   ? -5.391  -65.375 -31.155 1.00 53.31  ? 1467 HOH A O   1 
HETATM 5188 O  O   . HOH M 8 .   ? -3.531  -50.741 -17.941 1.00 49.97  ? 1468 HOH A O   1 
HETATM 5189 O  O   . HOH M 8 .   ? -30.853 -59.939 -34.523 1.00 49.75  ? 1469 HOH A O   1 
HETATM 5190 O  O   . HOH M 8 .   ? 9.015   -43.017 -32.946 1.00 65.35  ? 1470 HOH A O   1 
HETATM 5191 O  O   . HOH M 8 .   ? -15.497 -45.637 -10.343 1.00 74.37  ? 1471 HOH A O   1 
HETATM 5192 O  O   . HOH M 8 .   ? 0.301   -62.606 -17.726 1.00 34.15  ? 1472 HOH A O   1 
HETATM 5193 O  O   . HOH M 8 .   ? -4.989  -66.783 -6.077  1.00 59.73  ? 1473 HOH A O   1 
HETATM 5194 O  O   . HOH M 8 .   ? -6.665  -45.155 -17.163 1.00 60.60  ? 1474 HOH A O   1 
HETATM 5195 O  O   . HOH M 8 .   ? -1.851  -55.482 -5.954  1.00 50.35  ? 1475 HOH A O   1 
HETATM 5196 O  O   . HOH M 8 .   ? 10.562  -47.881 -35.404 1.00 63.85  ? 1476 HOH A O   1 
HETATM 5197 O  O   . HOH M 8 .   ? -41.424 -56.847 -13.704 1.00 32.07  ? 1477 HOH A O   1 
HETATM 5198 O  O   . HOH M 8 .   ? -9.646  -40.554 -42.379 1.00 53.32  ? 1478 HOH A O   1 
HETATM 5199 O  O   . HOH M 8 .   ? -35.443 -62.524 -29.318 1.00 75.05  ? 1479 HOH A O   1 
HETATM 5200 O  O   . HOH M 8 .   ? -15.530 -41.940 -38.643 1.00 35.28  ? 1480 HOH A O   1 
HETATM 5201 O  O   . HOH M 8 .   ? -35.803 -48.281 -14.064 1.00 47.43  ? 1481 HOH A O   1 
HETATM 5202 O  O   . HOH M 8 .   ? -24.193 -36.257 -35.021 1.00 48.41  ? 1482 HOH A O   1 
HETATM 5203 O  O   . HOH M 8 .   ? -32.225 -75.478 -7.473  1.00 66.63  ? 1483 HOH A O   1 
HETATM 5204 O  O   . HOH M 8 .   ? -4.327  -49.511 3.190   1.00 69.04  ? 1484 HOH A O   1 
HETATM 5205 O  O   . HOH M 8 .   ? -14.374 -38.283 -40.651 0.50 45.79  ? 1485 HOH A O   1 
HETATM 5206 O  O   . HOH M 8 .   ? -1.181  -63.113 -15.308 1.00 49.94  ? 1486 HOH A O   1 
HETATM 5207 O  O   . HOH M 8 .   ? -18.251 -68.040 -6.473  1.00 24.63  ? 1487 HOH A O   1 
HETATM 5208 O  O   . HOH M 8 .   ? -25.230 -27.920 -20.004 1.00 56.25  ? 1488 HOH A O   1 
HETATM 5209 O  O   . HOH M 8 .   ? -29.004 -21.798 -42.831 1.00 58.11  ? 1489 HOH A O   1 
HETATM 5210 O  O   . HOH M 8 .   ? -2.927  -56.674 -33.958 1.00 49.46  ? 1490 HOH A O   1 
HETATM 5211 O  O   . HOH M 8 .   ? -28.295 -65.312 -42.500 1.00 50.82  ? 1491 HOH A O   1 
HETATM 5212 O  O   . HOH M 8 .   ? -5.589  -64.380 -6.611  1.00 34.40  ? 1492 HOH A O   1 
HETATM 5213 O  O   . HOH M 8 .   ? -19.541 -46.483 -19.154 1.00 76.03  ? 1493 HOH A O   1 
HETATM 5214 O  O   . HOH M 8 .   ? -19.984 -68.448 -4.373  1.00 29.29  ? 1494 HOH A O   1 
HETATM 5215 O  O   . HOH M 8 .   ? -1.280  -55.174 -0.850  1.00 41.94  ? 1495 HOH A O   1 
HETATM 5216 O  O   . HOH M 8 .   ? -2.931  -59.612 -6.593  0.48 39.23  ? 1496 HOH A O   1 
HETATM 5217 O  O   . HOH M 8 .   ? 16.621  -34.288 -27.048 1.00 51.78  ? 1497 HOH A O   1 
HETATM 5218 O  O   . HOH M 8 .   ? -2.793  -59.690 -0.532  1.00 40.25  ? 1498 HOH A O   1 
HETATM 5219 O  O   . HOH M 8 .   ? -25.395 -43.941 -33.298 1.00 58.15  ? 1499 HOH A O   1 
HETATM 5220 O  O   . HOH M 8 .   ? -44.372 -68.141 -15.881 1.00 56.56  ? 1500 HOH A O   1 
HETATM 5221 O  O   . HOH M 8 .   ? -1.619  -59.370 -3.272  1.00 49.04  ? 1501 HOH A O   1 
HETATM 5222 O  O   . HOH M 8 .   ? 10.063  -20.890 -25.807 1.00 52.61  ? 1502 HOH A O   1 
HETATM 5223 O  O   . HOH M 8 .   ? -9.471  -23.874 -3.881  1.00 57.01  ? 1503 HOH A O   1 
HETATM 5224 O  O   . HOH M 8 .   ? -12.220 -35.528 -44.351 0.50 59.87  ? 1504 HOH A O   1 
HETATM 5225 O  O   . HOH M 8 .   ? -11.933 -38.147 -44.048 0.50 50.36  ? 1505 HOH A O   1 
HETATM 5226 O  O   . HOH M 8 .   ? -34.017 -67.946 -22.892 1.00 67.94  ? 1506 HOH A O   1 
HETATM 5227 O  O   . HOH M 8 .   ? -28.300 -56.030 -45.336 1.00 62.38  ? 1507 HOH A O   1 
HETATM 5228 O  O   . HOH M 8 .   ? 12.920  -25.470 -26.957 1.00 61.31  ? 1508 HOH A O   1 
HETATM 5229 O  O   . HOH M 8 .   ? -22.597 -41.379 -44.041 1.00 62.60  ? 1509 HOH A O   1 
HETATM 5230 O  O   . HOH M 8 .   ? -32.068 -19.626 -5.315  1.00 67.24  ? 1510 HOH A O   1 
HETATM 5231 O  O   . HOH M 8 .   ? -3.862  -61.906 -10.502 0.48 45.80  ? 1511 HOH A O   1 
HETATM 5232 O  O   . HOH M 8 .   ? -3.995  -63.092 -8.158  0.48 44.22  ? 1512 HOH A O   1 
HETATM 5233 O  O   . HOH M 8 .   ? -43.249 -60.492 -2.020  1.00 49.17  ? 1513 HOH A O   1 
HETATM 5234 O  O   . HOH M 8 .   ? -1.433  -63.865 -8.035  0.48 44.82  ? 1514 HOH A O   1 
# 
